# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Na_Pi_cotrans PF02690.15 PIK32838.1 - 5.6e-25 88.1 6.7 7.6e-25 87.6 6.7 1.2 1 0 0 1 1 1 1 Na+/Pi-cotransporter Asp PF00026.23 PIK32839.1 - 2e-35 122.7 0.0 2.1e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease MULE PF10551.9 PIK32840.1 - 5.2e-14 52.4 0.1 9e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain DER1 PF04511.15 PIK32842.1 - 1.3e-42 145.9 5.8 1.9e-42 145.4 5.8 1.2 1 0 0 1 1 1 1 Der1-like family MCLC PF05934.11 PIK32842.1 - 0.17 10.5 4.1 0.22 10.2 4.1 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Sushi PF00084.20 PIK32843.1 - 0.0016 19.0 1.2 0.0028 18.2 1.2 1.5 1 1 0 1 1 1 1 Sushi repeat (SCR repeat) Arr-ms PF12120.8 PIK32843.1 - 0.17 12.1 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Rifampin ADP-ribosyl transferase MFS_5 PF05631.14 PIK32844.1 - 1.2e-10 40.9 1.8 1.5e-10 40.6 1.8 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 PIK32844.1 - 2.7e-06 26.6 5.6 3.1e-06 26.3 5.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Peptidase_M73 PF12389.8 PIK32844.1 - 0.31 10.9 0.4 0.51 10.1 0.2 1.4 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase DUF202 PF02656.15 PIK32844.1 - 3.7 8.1 5.1 18 5.9 0.1 2.9 1 1 3 4 4 4 0 Domain of unknown function (DUF202) Arylesterase PF01731.20 PIK32845.1 - 2.8e-15 56.3 0.1 6.3e-15 55.1 0.1 1.5 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 PIK32845.1 - 0.0042 16.7 0.0 0.0045 16.6 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 PIK32845.1 - 0.016 15.3 0.1 0.071 13.2 0.1 1.9 2 0 0 2 2 2 0 Strictosidine synthase Gar1 PF04410.14 PIK32846.1 - 3.4e-23 82.1 0.0 3.7e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Abhydrolase_1 PF00561.20 PIK32849.1 - 1.6e-15 57.5 0.0 5.2e-15 55.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK32849.1 - 3.1e-10 41.0 0.0 3.9e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK32849.1 - 4e-05 23.0 0.0 5.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 RRM_1 PF00076.22 PIK32851.1 - 1.5e-26 92.0 0.0 2e-23 82.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 PIK32851.1 - 1.1e-17 64.9 4.0 1.1e-17 64.9 4.0 2.6 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein DUF1866 PF08952.11 PIK32851.1 - 0.0019 18.0 0.0 0.3 10.9 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1866) RRM_occluded PF16842.5 PIK32851.1 - 0.0024 17.7 0.0 0.0091 15.8 0.0 2.0 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 PIK32851.1 - 0.0063 16.1 0.0 0.016 14.8 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Polyoma_coat2 PF00761.20 PIK32851.1 - 0.03 14.1 0.2 0.046 13.4 0.2 1.2 1 0 0 1 1 1 0 Polyomavirus coat protein Glyco_transf_29 PF00777.18 PIK32852.1 - 3.9e-18 65.8 1.0 4.2e-18 65.7 1.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ank_4 PF13637.6 PIK32853.1 - 3.2e-19 69.0 3.8 2e-05 25.0 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK32853.1 - 1.8e-18 66.9 0.7 4.1e-12 46.5 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK32853.1 - 3.9e-14 52.3 6.5 0.00066 20.0 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK32853.1 - 7.7e-13 48.4 3.4 0.00014 22.1 0.3 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK32853.1 - 1.9e-12 46.2 2.0 0.067 13.8 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat HSP70 PF00012.20 PIK32854.1 - 2.9e-88 296.6 0.2 3.3e-88 296.4 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK32854.1 - 1.5e-13 50.3 0.4 4.9e-13 48.6 0.4 1.7 1 1 0 1 1 1 1 MreB/Mbl protein StbA PF06406.11 PIK32854.1 - 0.0012 18.1 0.1 0.0029 16.9 0.0 1.6 1 1 0 1 1 1 1 StbA protein TPP_enzyme_N PF02776.18 PIK32854.1 - 0.03 13.9 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain FGGY_C PF02782.16 PIK32854.1 - 0.052 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Histidinol_dh PF00815.20 PIK32854.1 - 0.091 11.7 0.2 0.19 10.7 0.2 1.4 1 0 0 1 1 1 0 Histidinol dehydrogenase CDC45 PF02724.14 PIK32855.1 - 3.6e-21 75.1 0.0 1.1e-20 73.5 0.0 1.7 1 1 0 1 1 1 1 CDC45-like protein C2-set_2 PF08205.12 PIK32856.1 - 1.9e-06 27.9 0.2 7.8e-06 25.9 0.1 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK32856.1 - 6.7e-06 26.2 0.4 0.023 14.8 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK32856.1 - 0.00014 22.4 0.0 1 10.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK32856.1 - 0.0013 18.8 0.2 0.0093 16.1 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK32856.1 - 0.013 15.9 0.1 0.1 13.0 0.1 2.2 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ion_trans_2 PF07885.16 PIK32857.1 - 7.6e-22 77.1 10.5 2.9e-14 52.8 3.1 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 PIK32857.1 - 0.0093 15.2 2.4 0.0093 15.2 2.4 2.1 2 0 0 2 2 2 1 Ion transport protein Pneumo_att_G PF05539.11 PIK32857.1 - 0.034 13.7 2.6 0.046 13.3 2.6 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF4834 PF16118.5 PIK32857.1 - 0.092 13.7 0.2 0.092 13.7 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) LapA_dom PF06305.11 PIK32857.1 - 0.1 12.5 0.5 16 5.4 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Consortin_C PF15281.6 PIK32857.1 - 0.18 11.8 0.0 0.18 11.8 0.0 2.9 2 2 2 4 4 4 0 Consortin C-terminus SseC PF04888.12 PIK32858.1 - 0.17 11.4 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DAG1 PF05454.11 PIK32862.1 - 1.6e-13 50.7 4.1 1.5e-12 47.5 4.1 2.1 1 1 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Glyco_transf_10 PF00852.19 PIK32863.1 - 1.4e-39 135.7 0.2 1.7e-39 135.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term 7tm_1 PF00001.21 PIK32864.1 - 1.1e-15 57.7 0.4 1.5e-15 57.2 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK32864.1 - 1.2e-07 31.4 2.2 1.5e-07 31.1 2.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK32864.1 - 0.0087 15.5 0.9 0.012 15.1 0.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF515 PF04415.12 PIK32864.1 - 0.088 11.2 0.1 0.11 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) ETRAMP PF09716.10 PIK32864.1 - 1.4 9.0 6.3 1.5 8.9 1.6 2.5 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Dynein_C PF18199.1 PIK32868.1 - 8e-08 31.9 0.0 9.2e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain RelE PF06296.12 PIK32869.1 - 0.0013 18.8 0.1 0.0016 18.6 0.1 1.0 1 0 0 1 1 1 1 RelE toxin of RelE / RelB toxin-antitoxin system DUF2937 PF11157.8 PIK32869.1 - 0.081 12.6 0.1 0.094 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) ALF PF03752.13 PIK32869.1 - 0.095 12.7 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Short repeats of unknown function SAM_2 PF07647.17 PIK32870.1 - 9.5e-13 48.1 0.4 1.2e-12 47.8 0.4 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK32870.1 - 2.3e-09 37.5 0.3 3.3e-09 37.0 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK32870.1 - 0.00014 21.7 0.1 0.00018 21.4 0.1 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 PIK32870.1 - 0.11 12.3 0.2 0.46 10.3 0.2 1.9 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) LOH1CR12 PF10158.9 PIK32871.1 - 0.12 12.4 0.2 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 Tumour suppressor protein DUF4482 PF14818.6 PIK32871.1 - 0.13 13.1 0.2 0.22 12.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) STN1_2 PF09170.10 PIK32872.1 - 2.7e-13 50.5 0.5 1.1e-12 48.5 0.3 1.8 2 0 0 2 2 2 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Cdc6_C PF09079.11 PIK32872.1 - 0.0065 16.4 0.1 0.014 15.4 0.1 1.6 1 1 1 2 2 2 1 CDC6, C terminal winged helix domain CLTH PF10607.9 PIK32873.1 - 4.4e-22 78.6 0.3 5.2e-22 78.3 0.3 1.0 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Aldo_ket_red PF00248.21 PIK32874.1 - 8e-26 90.9 0.0 9.9e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF676 PF05057.14 PIK32875.1 - 0.057 12.9 0.0 0.061 12.8 0.0 1.0 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Pro_racemase PF05544.11 PIK32876.1 - 5.1e-43 147.4 0.2 6.1e-43 147.1 0.2 1.0 1 0 0 1 1 1 1 Proline racemase ABC_tran PF00005.27 PIK32877.1 - 1.7e-13 51.3 0.0 2.4e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK32877.1 - 0.0056 16.1 0.1 0.0061 16.0 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Acyl_transf_2 PF02273.15 PIK32877.1 - 0.036 13.3 0.1 0.045 13.0 0.1 1.1 1 0 0 1 1 1 0 Acyl transferase PhoLip_ATPase_C PF16212.5 PIK32878.1 - 1.8e-50 172.0 15.9 2.1e-50 171.8 15.9 1.0 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal WASH-7_C PF14746.6 PIK32879.1 - 1.3e-12 47.8 0.3 1.3e-12 47.8 0.3 1.9 2 0 0 2 2 2 1 WASH complex subunit 7, C-terminal Peptidase_M14 PF00246.24 PIK32880.1 - 4.3e-21 76.0 0.0 5e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Peptidase_C97 PF05903.14 PIK32881.1 - 0.017 15.0 0.6 0.031 14.1 0.5 1.5 1 1 0 1 1 1 0 PPPDE putative peptidase domain DUF778 PF05608.12 PIK32881.1 - 0.036 14.5 0.0 0.037 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) LRAT PF04970.13 PIK32881.1 - 0.062 13.6 0.6 0.066 13.5 0.6 1.5 1 1 0 1 1 1 0 Lecithin retinol acyltransferase Asp PF00026.23 PIK32882.1 - 5e-37 128.0 0.2 5.6e-37 127.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 PIK32882.1 - 0.00024 21.4 0.0 0.00026 21.3 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Mucin2_WxxW PF13330.6 PIK32883.1 - 3.5e-27 95.1 38.4 4e-10 40.4 7.7 3.6 3 0 0 3 3 3 3 Mucin-2 protein WxxW repeating region CHGN PF05679.16 PIK32884.1 - 1.7e-61 208.6 0.9 1.7e-58 198.7 0.0 2.1 1 1 1 2 2 2 2 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 PIK32884.1 - 9.4e-13 47.6 0.3 2.2e-12 46.4 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK32884.1 - 0.00043 19.8 0.2 0.0015 18.1 0.2 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 ECSCR PF15820.5 PIK32885.1 - 0.085 12.7 2.7 0.18 11.7 2.7 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 PIK32885.1 - 0.087 13.7 0.4 0.15 12.9 0.4 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FeoB_associated PF12669.7 PIK32885.1 - 1.3 9.5 5.9 5.6 7.4 5.9 2.1 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Zona_pellucida PF00100.23 PIK32887.1 - 0.12 12.2 1.2 0.16 11.7 1.2 1.2 1 0 0 1 1 1 0 Zona pellucida-like domain RasGEF PF00617.19 PIK32888.1 - 1.6e-17 64.3 1.3 2.1e-17 63.9 0.2 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 PIK32888.1 - 1.3e-09 38.2 1.5 8.5e-08 32.4 0.1 3.1 2 0 0 2 2 2 1 RasGEF N-terminal motif TniB PF05621.11 PIK32888.1 - 0.0045 16.4 0.1 0.0094 15.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial TniB protein HR1 PF02185.16 PIK32888.1 - 0.74 10.0 6.9 0.42 10.8 3.4 2.4 2 0 0 2 2 2 0 Hr1 repeat zf-Di19 PF05605.12 PIK32889.1 - 0.81 10.0 7.9 1.3 9.4 0.9 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK32889.1 - 4.8 8.3 15.2 2.4 9.2 2.2 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger BTB_2 PF02214.22 PIK32890.1 - 4.3e-10 39.8 0.1 1.2e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 PIK32890.1 - 0.087 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Collagen PF01391.18 PIK32891.1 - 1.4e-12 47.2 38.5 7.7e-07 28.8 19.6 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) C1q PF00386.21 PIK32891.1 - 1.4e-06 28.5 0.0 2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 C1q domain Neuromodulin_N PF10580.9 PIK32892.1 - 0.17 11.7 4.9 0.19 11.6 0.6 2.5 2 0 0 2 2 2 0 Gap junction protein N-terminal region DUF5538 PF17692.1 PIK32893.1 - 1.9 8.6 5.0 0.49 10.5 2.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5538) Complex1_51K PF01512.17 PIK32894.1 - 2.8e-40 137.7 0.0 3.4e-40 137.4 0.0 1.0 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit DUF3568 PF12092.8 PIK32894.1 - 0.014 15.4 0.8 0.023 14.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Put_Phosphatase PF06888.12 PIK32895.1 - 6.7e-54 182.8 0.4 8e-54 182.5 0.4 1.1 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 PIK32895.1 - 1.7e-06 28.6 0.0 4.7e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_tranf_2_4 PF13704.6 PIK32895.1 - 0.0097 16.4 0.0 0.33 11.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 OB_NTP_bind PF07717.16 PIK32896.1 - 1.2e-16 60.8 0.0 2e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold p450 PF00067.22 PIK32897.1 - 4.6e-34 118.0 0.1 5.5e-34 117.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Na_Pi_cotrans PF02690.15 PIK32898.1 - 2.4e-25 89.3 4.6 3.1e-25 88.9 4.6 1.2 1 0 0 1 1 1 1 Na+/Pi-cotransporter SprT-like PF10263.9 PIK32899.1 - 4.4e-25 87.7 1.5 7e-25 87.1 1.5 1.4 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 PIK32899.1 - 0.0053 16.6 4.9 0.012 15.5 4.9 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 PIK32899.1 - 0.017 15.5 1.2 0.039 14.4 0.3 2.0 2 0 0 2 2 2 0 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK32899.1 - 0.022 15.4 1.7 0.078 13.6 0.3 2.3 2 0 0 2 2 2 0 HMG-box domain 7tm_1 PF00001.21 PIK32900.1 - 2.6e-55 187.6 10.8 3.3e-55 187.2 10.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK32900.1 - 3.3e-07 30.3 16.9 2.1e-06 27.7 11.4 2.4 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK32900.1 - 0.0013 18.4 20.6 0.0013 18.4 20.6 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx PAZ PF02170.22 PIK32901.1 - 0.011 15.5 0.4 0.023 14.5 0.4 1.5 1 0 0 1 1 1 0 PAZ domain VP7 PF00434.18 PIK32901.1 - 0.11 11.6 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Glycoprotein VP7 DUF4572 PF15139.6 PIK32901.1 - 0.15 12.0 3.4 0.55 10.1 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4572) Zip PF02535.22 PIK32903.1 - 1.1e-19 70.8 0.0 1.3e-19 70.6 0.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter CN_hydrolase PF00795.22 PIK32904.1 - 5.6e-30 104.6 0.0 7.1e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Acyl-CoA_dh_M PF02770.19 PIK32905.1 - 5e-27 93.9 0.0 6.8e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 PIK32905.1 - 1.5e-08 35.0 0.0 2.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK32905.1 - 0.00015 22.3 0.0 0.00033 21.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain HpaB_N PF11794.8 PIK32905.1 - 0.069 12.8 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Pept_tRNA_hydro PF01195.19 PIK32905.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase NTR PF01759.21 PIK32907.1 - 0.0016 18.2 0.0 0.0021 17.8 0.0 1.1 1 0 0 1 1 1 1 UNC-6/NTR/C345C module SpoIISA_toxin PF14171.6 PIK32907.1 - 0.0091 15.7 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Toxin SpoIISA, type II toxin-antitoxin system TIMP PF00965.17 PIK32907.1 - 0.029 14.2 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase DUF2890 PF11081.8 PIK32907.1 - 0.14 12.2 0.1 0.17 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) ADH_zinc_N PF00107.26 PIK32908.1 - 1.9e-22 79.7 0.1 3.1e-22 78.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK32908.1 - 3.3e-15 57.3 0.0 4.9e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK32908.1 - 6.7e-11 42.0 0.0 1.6e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 PIK32908.1 - 0.02 14.8 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase bZIP_2 PF07716.15 PIK32910.1 - 2.1e-16 59.7 6.8 2.1e-16 59.7 6.8 1.9 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 PIK32910.1 - 1.6e-05 24.9 8.8 2.9e-05 24.1 8.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 PIK32910.1 - 0.0054 16.8 1.0 0.012 15.7 1.0 1.5 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 Vps39_1 PF10366.9 PIK32910.1 - 0.03 14.6 0.9 0.047 14.0 0.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 bZIP_Maf PF03131.17 PIK32910.1 - 0.36 11.4 9.6 0.085 13.4 6.6 1.5 2 0 0 2 2 2 0 bZIP Maf transcription factor Sulf_transp PF04143.14 PIK32911.1 - 1.4e-26 93.8 17.4 1.6e-26 93.6 17.4 1.0 1 0 0 1 1 1 1 Sulphur transport Med22 PF06179.12 PIK32913.1 - 3.1e-29 101.3 1.3 4.7e-29 100.7 1.3 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK32913.1 - 0.044 13.9 6.9 0.11 12.6 3.7 2.1 2 0 0 2 2 2 0 Polo kinase kinase Ribosomal_L29 PF00831.23 PIK32914.1 - 4.9e-21 74.5 3.0 4.9e-21 74.5 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK32914.1 - 0.029 14.3 0.3 0.046 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein Acyl-CoA_dh_N PF02771.16 PIK32915.1 - 9.1e-32 110.1 0.0 1.2e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK32915.1 - 5.6e-09 36.1 0.0 9.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 PIK32915.1 - 0.012 16.1 0.0 0.015 15.8 0.0 1.4 1 1 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal SHIPPO-rpt PF07004.12 PIK32916.1 - 0.031 15.2 0.1 0.085 13.8 0.1 1.8 1 0 0 1 1 1 0 Sperm-tail PG-rich repeat 7tm_1 PF00001.21 PIK32918.1 - 1.3e-35 123.0 8.3 1.7e-35 122.6 8.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK32918.1 - 1.1e-09 38.5 7.3 1.3e-09 38.2 7.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK32918.1 - 9.3e-08 32.0 12.4 1.2e-07 31.6 12.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK32918.1 - 4.9e-07 29.4 8.0 5.6e-07 29.2 8.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glyco_hydro_59M PF17387.2 PIK32919.1 - 3.2e-13 49.8 0.6 7.6e-13 48.6 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 59 central domain DUF1080 PF06439.11 PIK32919.1 - 0.029 14.5 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Med22 PF06179.12 PIK32920.1 - 1.9e-08 34.4 1.0 2.2e-08 34.2 0.1 1.5 2 0 0 2 2 2 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK32920.1 - 0.011 15.8 3.2 0.013 15.7 3.2 1.1 1 0 0 1 1 1 0 Polo kinase kinase Put_Phosphatase PF06888.12 PIK32921.1 - 2.1e-52 177.9 1.8 2.4e-52 177.7 1.8 1.1 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 PIK32921.1 - 1.2e-06 29.1 0.0 3.4e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_tranf_2_4 PF13704.6 PIK32921.1 - 0.0091 16.5 0.0 0.28 11.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 DAD PF02109.16 PIK32922.1 - 3.4e-26 91.7 1.7 3.7e-26 91.6 1.7 1.0 1 0 0 1 1 1 1 DAD family Rhodanese PF00581.20 PIK32923.1 - 1.4e-22 80.2 0.0 5e-14 52.7 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain GFP PF01353.22 PIK32923.1 - 0.019 14.5 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Green fluorescent protein SAP PF02037.27 PIK32924.1 - 5.5e-05 22.8 1.1 5.5e-05 22.8 1.1 1.9 2 0 0 2 2 2 1 SAP domain Ish1 PF10281.9 PIK32924.1 - 0.0065 16.7 0.2 0.013 15.8 0.2 1.6 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein Rbsn PF11464.8 PIK32925.1 - 3e-13 49.2 1.4 7.2e-13 48.0 0.5 2.2 1 1 1 2 2 2 1 Rabenosyn Rab binding domain PWWP PF00855.17 PIK32925.1 - 0.058 13.8 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 PWWP domain PEHE PF15275.6 PIK32925.1 - 0.45 11.2 8.3 0.46 11.1 7.2 1.7 1 1 0 1 1 1 0 PEHE domain FtsJ PF01728.19 PIK32928.1 - 4.2e-69 232.2 0.0 5.3e-69 231.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase 7tm_1 PF00001.21 PIK32929.1 - 3.3e-24 85.6 8.6 4.3e-24 85.3 8.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK32929.1 - 7.6e-13 48.7 6.3 9.8e-13 48.3 6.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK32929.1 - 3.7e-08 33.1 2.6 5.6e-08 32.5 2.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Saf_2TM PF18303.1 PIK32929.1 - 0.032 13.8 0.2 0.061 12.9 0.2 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Myotoxins PF00819.17 PIK32929.1 - 0.091 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Myotoxin, crotamine 7TM_GPCR_Srv PF10323.9 PIK32929.1 - 0.092 12.1 8.2 0.11 11.8 6.6 1.8 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF3291 PF11695.8 PIK32929.1 - 0.15 11.7 0.4 0.21 11.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) DUF1430 PF07242.11 PIK32929.1 - 0.52 10.6 5.2 2.7 8.3 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1430) PAXX PF15384.6 PIK32931.1 - 0.046 13.4 0.1 0.067 12.9 0.1 1.2 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 DUF1451 PF07295.11 PIK32932.1 - 1.9 8.5 8.4 6.6 6.8 0.8 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain AAA_12 PF13087.6 PIK32933.1 - 3.8e-07 29.9 0.0 5.6e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Dynein_C PF18199.1 PIK32934.1 - 3.5e-13 49.5 0.0 3.8e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain HALZ PF02183.18 PIK32935.1 - 0.0089 16.2 6.0 0.19 12.0 0.8 3.5 2 0 0 2 2 2 1 Homeobox associated leucine zipper RE_NgoFVII PF09565.10 PIK32935.1 - 0.13 11.6 11.0 0.045 13.1 7.2 1.9 1 1 2 3 3 3 0 NgoFVII restriction endonuclease DUF4407 PF14362.6 PIK32935.1 - 0.74 9.1 15.3 1.2 8.5 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 PIK32935.1 - 1.7 7.4 10.5 2.6 6.8 10.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 PIK32935.1 - 3 7.3 13.2 5.6 6.4 13.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ax_dynein_light PF10211.9 PIK32935.1 - 4.9 7.0 27.7 0.19 11.6 16.0 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain Rootletin PF15035.6 PIK32935.1 - 5.2 7.1 26.8 2.6e+02 1.5 25.1 3.0 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ALMT PF11744.8 PIK32935.1 - 8.9 5.0 11.4 13 4.4 11.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RVT_1 PF00078.27 PIK32937.1 - 6.7e-16 58.5 0.0 9.6e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK32937.1 - 0.00096 18.7 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) CHGN PF05679.16 PIK32938.1 - 3.8e-80 270.2 0.2 4.7e-80 269.9 0.2 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 PIK32938.1 - 1.3e-12 47.1 0.3 3.1e-12 46.0 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK32938.1 - 0.00033 20.2 0.2 0.0012 18.4 0.2 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Cystatin PF00031.21 PIK32938.1 - 0.076 13.3 0.1 0.78 10.1 0.0 2.4 2 0 0 2 2 2 0 Cystatin domain CARD PF00619.21 PIK32939.1 - 5.7e-22 77.6 1.4 1.2e-10 41.3 0.0 2.1 2 0 0 2 2 2 2 Caspase recruitment domain CARD_2 PF16739.5 PIK32939.1 - 2.7e-06 27.3 0.2 0.0072 16.3 0.0 2.3 2 1 0 2 2 2 2 Caspase recruitment domain MA-Mit PF09245.10 PIK32939.1 - 0.057 12.9 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen ESX-1_EspG PF14011.6 PIK32939.1 - 0.17 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 EspG family Mak10 PF04112.13 PIK32940.1 - 0.07 12.6 0.0 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase FAD-oxidase_C PF02913.19 PIK32941.1 - 1.3e-37 129.7 0.0 1.5e-37 129.6 0.0 1.0 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Ank_2 PF12796.7 PIK32942.1 - 1.8e-20 73.3 1.0 1.1e-10 42.0 0.2 3.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK32942.1 - 6.1e-19 66.1 0.4 9.1e-06 25.7 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 PIK32942.1 - 8.2e-19 67.7 2.2 3.1e-06 27.6 0.0 4.5 3 1 0 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK32942.1 - 7.4e-18 64.4 1.4 2.9e-05 24.3 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK32942.1 - 3.6e-16 58.8 0.7 1.1e-05 25.7 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat YrbL-PhoP_reg PF10707.9 PIK32943.1 - 0.068 12.7 2.2 0.097 12.2 1.4 1.6 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL Pacs-1 PF10254.9 PIK32943.1 - 0.61 9.0 9.3 0.93 8.4 9.3 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein DUF1866 PF08952.11 PIK32944.1 - 0.005 16.7 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Med22 PF06179.12 PIK32945.1 - 3.1e-29 101.3 1.3 4.7e-29 100.7 1.3 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK32945.1 - 0.044 13.9 6.9 0.11 12.6 3.7 2.1 2 0 0 2 2 2 0 Polo kinase kinase Ribosomal_L29 PF00831.23 PIK32946.1 - 4.9e-21 74.5 3.0 4.9e-21 74.5 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK32946.1 - 0.029 14.3 0.3 0.046 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein PX PF00787.24 PIK32947.1 - 1.5e-23 83.0 3.3 2.2e-23 82.4 3.3 1.2 1 0 0 1 1 1 1 PX domain Sulfotransfer_2 PF03567.14 PIK32948.1 - 3.3e-27 96.0 1.8 4.4e-27 95.6 1.8 1.1 1 0 0 1 1 1 1 Sulfotransferase family p450 PF00067.22 PIK32949.1 - 1.4e-74 251.5 0.0 1.7e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Med22 PF06179.12 PIK32950.1 - 1.9e-08 34.4 1.0 2.2e-08 34.2 0.1 1.5 2 0 0 2 2 2 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK32950.1 - 0.011 15.8 3.2 0.013 15.7 3.2 1.1 1 0 0 1 1 1 0 Polo kinase kinase Ribosomal_L29 PF00831.23 PIK32951.1 - 4.9e-21 74.5 3.0 4.9e-21 74.5 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK32951.1 - 0.029 14.3 0.3 0.046 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein bZIP_1 PF00170.21 PIK32952.1 - 0.0051 16.9 1.0 0.0051 16.9 1.0 3.7 4 0 0 4 4 4 1 bZIP transcription factor DUF3450 PF11932.8 PIK32952.1 - 0.0054 16.1 17.1 0.14 11.4 3.2 2.6 1 1 0 2 2 2 2 Protein of unknown function (DUF3450) SPK PF04435.18 PIK32952.1 - 0.0062 16.9 4.4 0.55 10.7 0.2 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF545) PKcGMP_CC PF16808.5 PIK32952.1 - 0.009 15.8 1.7 0.009 15.8 1.7 4.7 5 0 0 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Csm1_N PF18504.1 PIK32952.1 - 0.021 15.1 2.6 0.021 15.1 2.6 5.2 4 2 1 5 5 5 0 Csm1 N-terminal domain APC_N_CC PF16689.5 PIK32952.1 - 0.063 13.4 4.0 1.6 8.9 0.1 3.3 2 1 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain FlaC_arch PF05377.11 PIK32952.1 - 0.071 13.5 10.2 0.33 11.4 0.6 3.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF2164 PF09932.9 PIK32952.1 - 2.3 8.4 6.6 35 4.6 0.1 3.6 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2164) ApoO PF09769.9 PIK32952.1 - 2.5 8.1 3.7 0.82 9.6 0.5 1.8 2 0 0 2 2 2 0 Apolipoprotein O SlyX PF04102.12 PIK32952.1 - 9.4 6.9 13.6 12 6.5 0.8 4.0 3 0 0 3 3 3 0 SlyX Abhydrolase_1 PF00561.20 PIK32953.1 - 4.2e-05 23.3 0.0 4.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK32953.1 - 0.0004 21.1 0.0 0.00047 20.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK32953.1 - 0.0056 16.0 0.0 0.0076 15.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Glyco_transf_29 PF00777.18 PIK32954.1 - 2.1e-14 53.6 0.0 3.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK32955.1 - 1.5e-36 126.2 0.0 1.7e-36 126.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_hydro_67C PF07477.12 PIK32955.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus LRR_9 PF14580.6 PIK32956.1 - 2.1e-08 33.8 4.7 1.6e-06 27.7 0.6 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 PIK32956.1 - 2.5e-08 33.6 9.5 1.5e-05 24.7 1.4 3.3 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK32956.1 - 3.7e-08 33.5 12.7 0.00062 20.1 0.5 3.7 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) ACCA PF03255.14 PIK32956.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TMEM132D_C PF15706.5 PIK32957.1 - 0.036 13.8 1.8 0.43 10.4 0.1 2.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Cadherin_C_2 PF16492.5 PIK32957.1 - 0.86 10.4 0.0 0.86 10.4 0.0 2.8 3 1 0 3 3 3 0 Cadherin cytoplasmic C-terminal DUF1180 PF06679.12 PIK32957.1 - 2.8 8.3 5.4 1.4 9.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) TauE PF01925.19 PIK32958.1 - 0.015 15.0 6.9 0.021 14.4 6.9 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Amastin PF07344.11 PIK32958.1 - 0.043 13.7 1.1 0.043 13.7 1.1 2.7 1 1 1 2 2 2 0 Amastin surface glycoprotein DUF5392 PF17370.2 PIK32958.1 - 0.35 10.9 0.8 6.6 6.8 0.2 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5392) TMEM132D_C PF15706.5 PIK32959.1 - 0.036 13.8 1.8 0.43 10.4 0.1 2.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Cadherin_C_2 PF16492.5 PIK32959.1 - 0.86 10.4 0.0 0.86 10.4 0.0 2.8 3 1 0 3 3 3 0 Cadherin cytoplasmic C-terminal DUF1180 PF06679.12 PIK32959.1 - 2.8 8.3 5.4 1.4 9.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) S-methyl_trans PF02574.16 PIK32960.1 - 7.2e-35 121.1 0.0 9.2e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DUF2200 PF09966.9 PIK32960.1 - 0.023 14.8 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) Neuromodulin_N PF10580.9 PIK32963.1 - 0.098 12.5 0.6 0.098 12.5 0.6 1.8 2 0 0 2 2 2 0 Gap junction protein N-terminal region Pkinase PF00069.25 PIK32964.1 - 0.00018 21.0 0.0 0.00032 20.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF2981 PF11200.8 PIK32964.1 - 4.1 7.1 7.3 4.9 6.8 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) MAP70 PF07058.11 PIK32964.1 - 5.8 5.5 15.4 8.7 5.0 15.4 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Amino_oxidase PF01593.24 PIK32965.1 - 2e-06 27.4 0.0 2.3e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Glyco_transf_29 PF00777.18 PIK32966.1 - 7.3e-41 140.4 0.7 1e-40 139.8 0.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) NT5C PF06941.12 PIK32966.1 - 0.078 12.8 0.1 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) SPATA6 PF14909.6 PIK32967.1 - 7.8e-35 120.0 0.1 9.1e-35 119.8 0.1 1.0 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 PCI PF01399.27 PIK32968.1 - 2e-09 37.9 1.3 3.3e-09 37.2 0.2 1.9 2 1 0 2 2 2 1 PCI domain LRR_6 PF13516.6 PIK32969.1 - 8.4e-10 37.9 20.3 0.0033 17.4 0.0 9.8 10 0 0 10 10 10 4 Leucine Rich repeat LRR_4 PF12799.7 PIK32969.1 - 2.2e-08 34.2 11.3 0.27 11.7 0.0 6.4 4 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK32969.1 - 0.0012 19.1 14.5 38 5.4 0.0 8.7 9 1 0 9 9 9 1 Leucine Rich Repeat EamA PF00892.20 PIK32970.1 - 6.3e-20 71.8 43.8 1.3e-12 48.1 13.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 PIK32970.1 - 0.026 15.2 4.3 0.026 15.2 4.3 4.1 4 0 0 4 4 4 0 Small Multidrug Resistance protein DUF4541 PF15074.6 PIK32971.1 - 3.6e-06 27.5 1.0 4.9e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4541) FAM183 PF14886.6 PIK32971.1 - 0.00057 20.6 4.8 0.011 16.5 4.8 2.4 1 1 0 1 1 1 1 FAM183A and FAM183B related mTERF PF02536.14 PIK32971.1 - 0.022 13.7 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 mTERF Tudor-knot PF11717.8 PIK32973.1 - 7.7e-10 38.5 0.3 2.5e-07 30.5 0.3 2.6 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Tudor_3 PF18115.1 PIK32973.1 - 1e-08 34.8 1.5 5.5e-07 29.3 0.0 2.9 3 0 0 3 3 3 1 DNA repair protein Crb2 Tudor domain MBT PF02820.18 PIK32973.1 - 2.3e-08 34.3 0.1 2.6e-06 27.7 0.1 2.4 2 0 0 2 2 2 1 mbt repeat Tudor_2 PF18104.1 PIK32973.1 - 1.8e-07 30.7 4.1 9.6e-07 28.4 0.0 3.6 5 0 0 5 5 5 1 Jumonji domain-containing protein 2A Tudor domain DUF1325 PF07039.11 PIK32973.1 - 1.5e-05 25.1 0.1 3.5e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 PIK32973.1 - 2.9e-05 23.8 4.3 0.00011 21.9 0.1 2.7 3 0 0 3 3 3 1 Lamin-B receptor of TUDOR domain Agenet PF05641.12 PIK32973.1 - 0.00048 20.5 0.8 0.12 12.9 0.2 2.8 2 0 0 2 2 2 1 Agenet domain DUF4537 PF15057.6 PIK32973.1 - 0.00074 19.5 0.1 0.0022 18.0 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) zf-C2H2 PF00096.26 PIK32973.1 - 0.002 18.5 1.7 0.0043 17.4 1.7 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 PIK32973.1 - 0.012 15.7 0.1 0.02 15.0 0.1 1.3 1 0 0 1 1 1 0 Aberrant zinc-finger Tudor_4 PF18358.1 PIK32973.1 - 0.018 14.6 0.2 0.039 13.6 0.2 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 53-BP1_Tudor PF09038.10 PIK32973.1 - 0.022 14.7 0.6 0.051 13.5 0.0 1.9 2 0 0 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor SAWADEE PF16719.5 PIK32973.1 - 0.066 13.2 0.3 0.066 13.2 0.3 1.9 2 0 0 2 2 2 0 SAWADEE domain Rad9_Rad53_bind PF08605.10 PIK32973.1 - 0.075 13.2 0.2 8.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding 7tm_1 PF00001.21 PIK32974.1 - 1.3e-28 100.1 9.3 2.2e-28 99.3 9.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4490 PF14892.6 PIK32975.1 - 0.063 13.3 1.5 0.21 11.7 0.1 2.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4490) HU-CCDC81_bac_2 PF18175.1 PIK32975.1 - 0.32 10.9 1.4 3.3 7.7 0.0 2.9 3 1 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Integrase_H2C2 PF17921.1 PIK32976.1 - 3.3e-18 65.6 0.3 6.2e-18 64.7 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK32976.1 - 8.1e-07 29.2 0.2 4.8e-06 26.7 0.1 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Cep57_CLD_2 PF14197.6 PIK32978.1 - 0.073 13.2 0.6 0.42 10.7 0.1 2.0 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 TPR_1 PF00515.28 PIK32979.1 - 8.2e-22 76.1 0.0 1.6e-06 27.7 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK32979.1 - 7.6e-17 60.0 0.1 5.7e-06 26.1 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK32979.1 - 1.4e-12 46.8 0.0 8.7e-05 22.4 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK32979.1 - 2.7e-11 43.6 3.1 0.022 15.0 0.0 4.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK32979.1 - 1.2e-10 41.2 3.7 0.0031 18.2 0.1 4.4 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK32979.1 - 3.6e-10 39.4 0.0 3.8e-05 23.3 0.0 3.4 1 1 2 3 3 3 2 TPR repeat TPR_7 PF13176.6 PIK32979.1 - 3.9e-10 39.0 0.3 0.053 13.6 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK32979.1 - 5.1e-10 39.0 1.0 0.00047 20.4 0.0 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK32979.1 - 1.3e-08 35.4 1.4 3.8e-07 30.7 0.6 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK32979.1 - 5.4e-08 33.2 0.1 0.0013 19.2 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK32979.1 - 6.4e-06 25.9 2.5 0.27 11.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 PIK32979.1 - 0.00011 22.4 0.0 1.6 9.1 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK32979.1 - 0.00039 20.5 0.9 0.07 13.3 0.0 2.5 2 1 1 3 3 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK32979.1 - 0.00045 20.4 0.1 0.0065 16.7 0.1 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 PIK32979.1 - 0.0036 17.4 0.0 1 9.5 0.0 3.1 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain DUF4248 PF14053.6 PIK32979.1 - 0.0082 16.1 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4248) TPR_6 PF13174.6 PIK32979.1 - 0.01 16.4 0.8 16 6.4 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 PIK32979.1 - 0.018 14.3 0.1 0.067 12.4 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1641 PF07849.11 PIK32979.1 - 0.062 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_3 PF07720.12 PIK32979.1 - 0.099 12.7 0.0 2.4 8.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK32979.1 - 0.12 12.4 0.1 9.6 6.4 0.0 2.6 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat NACHT PF05729.12 PIK32980.1 - 7.7e-15 55.2 0.1 1.2e-14 54.5 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK32980.1 - 0.00017 22.0 1.8 0.0023 18.3 1.8 2.4 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK32980.1 - 0.00058 19.1 0.0 0.00089 18.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK32980.1 - 0.001 19.3 0.0 0.0025 18.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.6 PIK32980.1 - 0.0024 18.2 0.0 0.01 16.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 PIK32980.1 - 0.0043 16.5 0.0 0.0067 15.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 PIK32980.1 - 0.007 15.9 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 PIK32980.1 - 0.0083 15.9 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 PIK32980.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 PIK32980.1 - 0.011 14.9 0.0 0.032 13.4 0.0 1.5 1 1 0 1 1 1 0 G-protein alpha subunit TniB PF05621.11 PIK32980.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 PIK32980.1 - 0.017 14.9 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 PIK32980.1 - 0.018 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 PIK32980.1 - 0.02 15.1 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 PIK32980.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 PIK32980.1 - 0.029 13.3 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.14 PIK32980.1 - 0.059 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 PIK32980.1 - 0.069 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 PIK32980.1 - 0.076 12.1 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 PIK32980.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 KaiC KAP_NTPase PF07693.14 PIK32980.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_18 PF13238.6 PIK32980.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ThiF PF00899.21 PIK32980.1 - 0.12 11.7 0.0 0.45 9.8 0.0 1.8 2 0 0 2 2 2 0 ThiF family Sigma54_activ_2 PF14532.6 PIK32980.1 - 0.13 12.4 0.0 0.57 10.3 0.0 2.0 2 1 1 3 3 2 0 Sigma-54 interaction domain SRP54 PF00448.22 PIK32980.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activat PF00158.26 PIK32980.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 PIK32980.1 - 0.14 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Glyco_hydro_31 PF01055.26 PIK32981.1 - 2.3e-05 23.8 0.0 0.00047 19.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Itfg2 PF15907.5 PIK32982.1 - 8.4e-69 232.2 0.2 1.3e-68 231.6 0.2 1.2 1 0 0 1 1 1 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 PIK32982.1 - 0.0025 17.8 0.0 0.0058 16.7 0.0 1.6 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region SBF PF01758.16 PIK32983.1 - 3.8e-31 108.3 6.6 3.8e-31 108.3 6.6 1.7 2 1 0 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK32983.1 - 0.019 13.4 2.2 0.091 11.1 0.3 2.2 2 0 0 2 2 2 0 Membrane transport protein DUF3925 PF13063.6 PIK32983.1 - 0.14 12.4 0.6 0.14 12.4 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3925) Pkinase_Tyr PF07714.17 PIK32985.1 - 5.6e-87 291.3 0.0 6.9e-87 291.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK32985.1 - 1.3e-32 113.2 0.0 2.3e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Y_phosphatase PF00102.27 PIK32986.1 - 3.3e-33 115.2 0.0 6.6e-33 114.2 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK32986.1 - 5.6e-05 23.0 0.0 0.00011 22.0 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK32986.1 - 0.0022 18.0 0.0 0.0054 16.7 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK32986.1 - 0.004 17.3 0.0 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 Inositol hexakisphosphate UvrD-helicase PF00580.21 PIK32986.1 - 0.14 11.6 0.0 0.39 10.2 0.0 1.6 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain p450 PF00067.22 PIK32987.1 - 3e-22 79.0 0.0 3.2e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HECT PF00632.25 PIK32988.1 - 7.7e-61 206.2 0.7 8.3e-61 206.1 0.7 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Use1 PF09753.9 PIK32989.1 - 3.3 7.4 6.9 2.8 7.6 0.4 2.1 2 0 0 2 2 2 0 Membrane fusion protein Use1 Phosphodiest PF01663.22 PIK32990.1 - 3e-60 204.7 4.2 3.5e-60 204.5 4.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK32990.1 - 3.1e-05 23.5 0.1 0.12 11.7 0.0 2.5 2 0 0 2 2 2 2 Sulfatase DUF229 PF02995.17 PIK32990.1 - 0.034 12.8 0.0 0.048 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) MFS_1 PF07690.16 PIK32992.1 - 5.9e-14 51.8 0.2 6.4e-14 51.6 0.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 PIK32993.1 - 1.4e-12 47.2 7.4 1.6e-12 47.0 7.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Nuc_H_symport PF03825.16 PIK32993.1 - 0.0089 15.1 11.3 0.067 12.2 11.3 2.0 1 1 0 1 1 1 1 Nucleoside H+ symporter DUF4271 PF14093.6 PIK32993.1 - 0.098 12.6 19.3 0.55 10.1 18.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) AAA PF00004.29 PIK32994.1 - 1.5e-37 129.0 0.0 2.6e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK32994.1 - 9e-10 38.2 0.0 3.9e-09 36.2 0.0 2.0 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 PIK32994.1 - 3.9e-09 36.4 0.0 1.3e-08 34.7 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 PIK32994.1 - 0.00046 20.0 0.0 0.0011 18.8 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 PIK32994.1 - 0.00074 19.7 0.1 0.007 16.5 0.0 2.4 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 PIK32994.1 - 0.00088 19.3 0.1 0.0046 17.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK32994.1 - 0.001 19.4 0.9 0.07 13.4 0.9 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK32994.1 - 0.0036 17.7 0.6 0.028 14.8 0.5 2.2 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 PIK32994.1 - 0.046 12.9 0.0 0.092 11.9 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 PIK32994.1 - 0.068 12.5 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 PIK32994.1 - 0.16 11.3 0.0 9 5.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 PIK32994.1 - 0.16 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK32994.1 - 0.17 11.4 0.1 4.8 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynein_C PF18199.1 PIK32995.1 - 2.2e-101 339.2 0.0 2.6e-101 338.9 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain FMP23 PF17315.2 PIK32995.1 - 0.19 11.9 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Found in mitochondrial proteome Plexin_cytopl PF08337.12 PIK32996.1 - 1.4e-104 350.8 0.0 1.6e-104 350.6 0.0 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain ArnB_C PF18677.1 PIK32997.1 - 0.02 15.0 0.7 0.02 15.0 0.7 1.9 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain UPRTase PF14681.6 PIK32998.1 - 1.7e-25 89.7 0.2 1.9e-25 89.6 0.2 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 PIK32998.1 - 0.11 12.0 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Phosphoribosyl transferase p450 PF00067.22 PIK32999.1 - 7.5e-54 183.2 0.1 1e-43 149.8 0.1 2.0 1 1 1 2 2 2 2 Cytochrome P450 PACT_coil_coil PF10495.9 PIK32999.1 - 0.004 17.7 0.0 0.009 16.6 0.0 1.7 1 1 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein LRR_4 PF12799.7 PIK33000.1 - 2.5e-11 43.6 10.9 1.7e-05 25.1 3.7 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK33000.1 - 2.1e-10 40.2 9.4 1.5e-06 27.9 3.0 2.4 2 0 0 2 2 2 2 Leucine rich repeat TMEM154 PF15102.6 PIK33000.1 - 7.5e-08 32.4 1.8 1.2e-07 31.7 1.8 1.2 1 0 0 1 1 1 1 TMEM154 protein family LRR_1 PF00560.33 PIK33000.1 - 4.5e-05 23.4 12.3 0.26 12.0 0.2 5.0 4 1 0 4 4 4 1 Leucine Rich Repeat Endomucin PF07010.12 PIK33000.1 - 6.6e-05 23.0 3.6 9.6e-05 22.5 3.6 1.2 1 0 0 1 1 1 1 Endomucin Orf78 PF06024.12 PIK33000.1 - 0.00013 22.3 0.3 0.00022 21.5 0.3 1.4 1 0 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 PIK33000.1 - 0.00025 21.1 0.2 0.00028 20.9 0.2 1.1 1 0 0 1 1 1 1 Rifin Shisa PF13908.6 PIK33000.1 - 0.0011 19.3 1.0 0.0016 18.7 1.0 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF5305 PF17231.2 PIK33000.1 - 0.0018 17.7 0.9 0.0028 17.1 0.9 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF5383 PF17355.2 PIK33000.1 - 0.0018 18.6 0.2 0.003 17.9 0.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5383) ECSCR PF15820.5 PIK33000.1 - 0.0031 17.3 0.9 0.0067 16.2 0.9 1.6 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator LRR_6 PF13516.6 PIK33000.1 - 0.0031 17.4 11.8 0.33 11.1 0.4 4.0 4 0 0 4 4 4 2 Leucine Rich repeat DUF3149 PF11346.8 PIK33000.1 - 0.0032 17.1 3.0 0.0058 16.2 3.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3149) SID-1_RNA_chan PF13965.6 PIK33000.1 - 0.005 15.3 0.7 0.006 15.1 0.7 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Glycophorin_A PF01102.18 PIK33000.1 - 0.0074 16.5 0.2 0.011 15.9 0.2 1.3 1 0 0 1 1 1 1 Glycophorin A DUF4366 PF14283.6 PIK33000.1 - 0.0081 16.2 0.2 0.013 15.6 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) PalH PF08733.10 PIK33000.1 - 0.01 14.9 0.6 0.015 14.3 0.6 1.3 1 0 0 1 1 1 0 PalH/RIM21 Peptidase_M56 PF05569.11 PIK33000.1 - 0.013 14.7 0.1 0.019 14.1 0.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 Baculo_11_kDa PF06143.11 PIK33000.1 - 0.013 15.0 0.1 0.024 14.2 0.1 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family LRRC37AB_C PF14914.6 PIK33000.1 - 0.016 15.1 4.6 0.027 14.4 4.6 1.5 1 1 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF4711 PF15829.5 PIK33000.1 - 0.018 15.0 2.5 0.023 14.6 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) BatD PF13584.6 PIK33000.1 - 0.034 13.0 0.0 0.044 12.6 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance DAG1 PF05454.11 PIK33000.1 - 0.035 13.5 0.1 0.041 13.2 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Presenilin PF01080.17 PIK33000.1 - 0.039 12.7 0.4 0.053 12.3 0.4 1.2 1 0 0 1 1 1 0 Presenilin ABC2_membrane_3 PF12698.7 PIK33000.1 - 0.046 12.8 0.0 0.046 12.8 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Vpu PF00558.19 PIK33000.1 - 0.052 13.3 2.9 0.12 12.1 2.9 1.6 1 0 0 1 1 1 0 Vpu protein Cadherin_C_2 PF16492.5 PIK33000.1 - 0.062 14.1 0.1 0.16 12.7 0.1 1.7 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal DUF4519 PF15012.6 PIK33000.1 - 0.07 13.3 0.8 0.07 13.3 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4519) Renin_r PF07850.14 PIK33000.1 - 0.083 13.5 0.1 0.13 12.9 0.1 1.3 1 0 0 1 1 1 0 Renin receptor-like protein EphA2_TM PF14575.6 PIK33000.1 - 0.096 13.6 0.9 0.21 12.5 0.9 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EVI2A PF05399.11 PIK33000.1 - 0.096 12.3 4.3 0.13 11.8 4.3 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) LRR_9 PF14580.6 PIK33000.1 - 0.14 11.7 3.6 1.4 8.3 0.3 2.2 1 1 1 2 2 2 0 Leucine-rich repeat Phage_holin_6_1 PF09682.10 PIK33000.1 - 0.17 12.3 3.2 0.29 11.6 3.2 1.3 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF3827 PF12877.7 PIK33000.1 - 1.3 7.4 3.9 2 6.7 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) OAD_gamma PF04277.13 PIK33000.1 - 6.9 7.3 5.3 1.3 9.7 0.9 1.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF1866 PF08952.11 PIK33002.1 - 0.005 16.7 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Myb_DNA-bind_5 PF13873.6 PIK33003.1 - 6.7e-11 42.1 0.5 2.9e-10 40.1 0.5 2.1 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 PIK33003.1 - 0.035 14.4 0.9 0.11 12.8 0.9 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-binding PF00249.31 PIK33003.1 - 0.038 14.2 0.0 0.11 12.7 0.0 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain NRBF2 PF08961.10 PIK33003.1 - 0.11 12.1 4.0 0.18 11.4 4.0 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator FtsL PF04999.13 PIK33003.1 - 0.43 10.6 2.7 1 9.4 2.7 1.6 1 0 0 1 1 1 0 Cell division protein FtsL LMBR1 PF04791.16 PIK33003.1 - 3.5 6.4 3.8 2.2 7.1 1.7 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein Ifi-6-16 PF06140.13 PIK33004.1 - 3e-17 62.3 24.9 3.7e-17 62.0 24.9 1.1 1 0 0 1 1 1 1 Interferon-induced 6-16 family SCAMP PF04144.13 PIK33004.1 - 8.9 6.6 9.5 8.1 6.7 8.6 1.4 1 1 1 2 2 2 0 SCAMP family ZIP4_domain PF18292.1 PIK33005.1 - 8.6e-19 68.1 2.8 2.1e-16 60.3 0.9 2.3 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain Zip PF02535.22 PIK33005.1 - 1e-17 64.4 1.7 1.8e-17 63.6 1.7 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter P16-Arc PF04699.14 PIK33006.1 - 8.9e-34 117.1 0.0 1e-33 116.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Ribosomal_L29 PF00831.23 PIK33007.1 - 5e-21 74.4 3.0 5e-21 74.4 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK33007.1 - 0.029 14.3 0.3 0.045 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein Med22 PF06179.12 PIK33008.1 - 3.1e-29 101.3 1.3 4.7e-29 100.7 1.3 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK33008.1 - 0.044 13.9 6.9 0.11 12.6 3.7 2.1 2 0 0 2 2 2 0 Polo kinase kinase Med22 PF06179.12 PIK33009.1 - 1.9e-08 34.4 1.0 2.2e-08 34.2 0.1 1.5 2 0 0 2 2 2 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK33009.1 - 0.011 15.8 3.2 0.013 15.7 3.2 1.1 1 0 0 1 1 1 0 Polo kinase kinase Ribosomal_L29 PF00831.23 PIK33010.1 - 4.9e-21 74.5 3.0 4.9e-21 74.5 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK33010.1 - 0.029 14.3 0.3 0.046 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein DAG1 PF05454.11 PIK33011.1 - 3e-10 40.0 3.6 2.2e-09 37.1 3.6 2.1 1 1 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Glyco_transf_10 PF00852.19 PIK33012.1 - 6.7e-44 149.7 0.3 1.1e-43 149.0 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK33012.1 - 1.2e-09 38.6 0.3 3e-09 37.3 0.3 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal LSM PF01423.22 PIK33013.1 - 1.5e-12 47.0 0.0 1.7e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain RabGAP-TBC PF00566.18 PIK33014.1 - 1.2e-08 34.9 0.1 1.3e-08 34.7 0.1 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain BTB_2 PF02214.22 PIK33015.1 - 1.1e-19 70.5 0.0 2.1e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK33015.1 - 0.0075 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain SNF PF00209.18 PIK33016.1 - 7.5e-54 183.3 18.7 2.8e-36 125.3 5.1 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family Med31 PF05669.12 PIK33017.1 - 5.1e-40 135.4 11.1 5.1e-40 135.4 11.1 2.0 2 0 0 2 2 2 1 SOH1 Presenilin PF01080.17 PIK33017.1 - 6.7 5.4 5.4 7.7 5.2 5.4 1.1 1 0 0 1 1 1 0 Presenilin MPM1 PF17234.2 PIK33017.1 - 7.8 6.7 10.6 5.2 7.3 9.2 1.4 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Pex14_N PF04695.13 PIK33017.1 - 10 6.8 16.9 15 6.2 16.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WD40 PF00400.32 PIK33018.1 - 9.2e-10 39.0 5.4 0.0015 19.3 0.5 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK33018.1 - 8.6e-09 35.6 0.1 0.0022 18.3 0.0 4.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.22 PIK33018.1 - 0.027 14.7 0.4 0.37 11.0 0.1 2.6 2 1 0 3 3 3 0 Ricin-type beta-trefoil lectin domain WD40_like PF17005.5 PIK33018.1 - 0.028 13.8 0.0 0.5 9.7 0.0 2.4 3 0 0 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 PIK33018.1 - 0.049 12.6 0.1 1.8 7.4 0.0 2.9 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK33018.1 - 0.13 10.9 0.5 1.5 7.4 0.0 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 SBP_bac_3 PF00497.20 PIK33019.1 - 0.00011 21.7 0.0 0.00037 20.0 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF5090 PF17009.5 PIK33019.1 - 0.018 15.0 0.1 0.024 14.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) TRAP_alpha PF03896.16 PIK33019.1 - 2.2 7.4 0.0 2.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PPP4R2 PF09184.11 PIK33019.1 - 2.3 7.8 16.2 3.1 7.3 16.2 1.2 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 PIK33019.1 - 4.5 6.5 32.1 7.6 5.8 32.1 1.4 1 0 0 1 1 1 0 NOA36 protein Spin-Ssty PF02513.17 PIK33021.1 - 9.2e-06 25.3 2.5 1.7e-05 24.5 2.5 1.4 1 0 0 1 1 1 1 Spin/Ssty Family Agenet PF05641.12 PIK33021.1 - 0.0012 19.3 1.0 0.0026 18.2 1.0 1.6 1 0 0 1 1 1 1 Agenet domain Homeodomain PF00046.29 PIK33022.1 - 7.4e-21 73.8 9.4 1.1e-20 73.2 9.4 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK33022.1 - 0.0094 15.8 0.5 0.017 15.0 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK33022.1 - 0.02 14.4 0.6 0.027 13.9 0.6 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Peptidase_S49_N PF08496.10 PIK33022.1 - 4.4 7.4 6.6 6.2 6.9 6.6 1.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal GET2 PF08690.10 PIK33024.1 - 0.09 12.4 12.5 0.11 12.2 12.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 STI1 PF17830.1 PIK33024.1 - 1.2 9.1 17.6 4.5 7.3 1.1 2.6 2 0 0 2 2 2 0 STI1 domain XPC-binding PF09280.11 PIK33024.1 - 1.5 8.6 14.5 1.1 9.1 2.5 2.5 2 0 0 2 2 2 0 XPC-binding domain DUF2059 PF09832.9 PIK33024.1 - 6.1 7.0 11.9 2.5 8.2 1.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2059) Put_Phosphatase PF06888.12 PIK33025.1 - 1.7e-41 142.1 0.1 1.9e-41 142.0 0.1 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 PIK33025.1 - 0.014 15.8 0.0 0.02 15.3 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TMEM70 PF06979.12 PIK33026.1 - 2e-35 122.0 0.1 2.8e-35 121.6 0.1 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Mononeg_mRNAcap PF14318.6 PIK33026.1 - 0.019 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V Carb_anhydrase PF00194.21 PIK33027.1 - 5e-28 98.3 0.0 5.5e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 PIK33028.1 - 4.2e-31 108.4 0.4 4.8e-31 108.2 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Lum_binding PF00677.17 PIK33028.1 - 0.094 12.7 0.1 0.15 12.0 0.1 1.6 1 1 0 1 1 1 0 Lumazine binding domain Zip PF02535.22 PIK33030.1 - 6.9e-56 189.9 20.7 4.9e-55 187.1 20.7 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter DUF4231 PF14015.6 PIK33030.1 - 8.1 7.0 7.0 13 6.3 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF5641 PF18701.1 PIK33031.1 - 3e-29 101.0 3.3 5.5e-29 100.2 3.3 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Peptidase_A17 PF05380.13 PIK33032.1 - 3.7e-11 43.3 0.0 7.8e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase Peptidase_A17 PF05380.13 PIK33033.1 - 3.2e-18 66.2 0.0 5.4e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase RPN6_N PF18055.1 PIK33033.1 - 0.0022 18.4 0.0 0.0041 17.5 0.0 1.6 1 1 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain fn3 PF00041.21 PIK33034.1 - 8.7e-06 26.0 0.1 1.7e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Gar1 PF04410.14 PIK33035.1 - 1.8e-29 102.5 0.0 2.1e-29 102.3 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region UPRTase PF14681.6 PIK33036.1 - 2.5e-14 53.2 0.0 2.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Lectin_C PF00059.21 PIK33037.1 - 3.3e-05 24.5 3.9 5.6e-05 23.8 3.9 1.4 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK33038.1 - 3.9e-05 24.3 3.0 7.3e-05 23.5 3.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK33039.1 - 3.3e-05 24.5 3.9 5.6e-05 23.8 3.9 1.4 1 0 0 1 1 1 1 Lectin C-type domain Pkinase_Tyr PF07714.17 PIK33040.1 - 3.2e-58 197.0 0.0 4.2e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK33040.1 - 5.5e-18 65.3 0.0 7.9e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF5444 PF17519.2 PIK33041.1 - 0.11 12.5 20.4 1.1 9.3 0.2 4.4 4 1 0 4 4 4 0 Family of unknown function (DUF5444) Pam17 PF08566.10 PIK33041.1 - 0.18 11.6 3.1 3.3 7.5 0.1 3.0 2 1 1 3 3 3 0 Mitochondrial import protein Pam17 Attachment_P66 PF11263.8 PIK33041.1 - 6.1 6.0 27.3 19 4.4 0.3 5.9 1 1 4 6 6 6 0 Borrelia burgdorferi attachment protein P66 Glyco_transf_29 PF00777.18 PIK33042.1 - 1.9e-15 57.0 0.0 3.3e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Abhydrolase_1 PF00561.20 PIK33043.1 - 1.6e-15 57.5 0.0 5.2e-15 55.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK33043.1 - 3.1e-10 41.0 0.0 3.9e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK33043.1 - 4e-05 23.0 0.0 5.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ephrin_rec_like PF07699.13 PIK33044.1 - 9.4e-25 86.1 24.3 8.4e-14 51.1 7.1 2.4 2 0 0 2 2 2 2 Putative ephrin-receptor like CUB PF00431.20 PIK33044.1 - 1.6e-12 47.7 0.0 2.7e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 CUB domain TNFR_c6 PF00020.18 PIK33044.1 - 0.00023 21.5 15.8 0.015 15.7 0.3 4.7 2 2 2 4 4 4 4 TNFR/NGFR cysteine-rich region DUF2318 PF10080.9 PIK33044.1 - 0.8 9.9 8.8 7.4 6.8 0.2 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) PTCB-BRCT PF12738.7 PIK33046.1 - 1.9e-22 79.0 0.4 1.1e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 PIK33046.1 - 2.9e-17 62.8 0.1 2.5e-12 47.0 0.0 3.3 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 PIK33046.1 - 2.4e-12 46.6 0.0 1.1e-11 44.5 0.0 2.0 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 PIK33046.1 - 2.9e-11 43.6 0.1 0.0011 19.3 0.0 3.2 3 0 0 3 3 3 3 BRCT domain, a BRCA1 C-terminus domain Thioredoxin_8 PF13905.6 PIK33046.1 - 0.01 16.2 0.0 0.048 14.0 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like LRR_8 PF13855.6 PIK33047.1 - 8.2e-18 63.9 14.3 2.2e-11 43.3 3.2 3.6 2 2 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 PIK33047.1 - 1.1e-12 47.9 12.0 8.9e-05 22.8 1.2 4.5 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK33047.1 - 4.2e-12 46.1 0.0 3.3e-11 43.3 0.0 1.8 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK33047.1 - 0.047 13.2 3.1 0.096 12.2 1.6 1.8 1 1 1 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 PIK33047.1 - 3.9 8.4 17.9 5.9 7.8 0.1 5.8 6 1 0 6 6 6 0 Leucine Rich Repeat Galactosyl_T PF01762.21 PIK33048.1 - 4.4e-42 144.1 0.0 6e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase GatB_Yqey PF02637.18 PIK33048.1 - 0.28 11.1 1.4 1.2 9.0 0.0 2.3 3 0 0 3 3 3 0 GatB domain Actin PF00022.19 PIK33049.1 - 8.6e-40 136.6 0.1 9e-31 106.9 0.1 2.8 2 1 0 2 2 2 2 Actin Vps8 PF12816.7 PIK33049.1 - 0.011 15.3 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Actin PF00022.19 PIK33050.1 - 5.3e-13 48.4 0.0 6.1e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Actin Galactosyl_T PF01762.21 PIK33051.1 - 6e-20 71.9 0.0 8.2e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 PIK33052.1 - 1.6e-27 96.6 0.1 2.3e-27 96.1 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase GatB_Yqey PF02637.18 PIK33052.1 - 0.12 12.2 1.1 0.91 9.4 0.0 2.3 2 1 0 2 2 2 0 GatB domain Actin PF00022.19 PIK33053.1 - 1.7e-114 382.6 0.7 2.6e-101 339.2 0.0 2.7 2 1 0 2 2 2 2 Actin Galactosyl_T PF01762.21 PIK33054.1 - 2e-44 151.7 0.0 6.3e-42 143.6 0.0 2.1 2 0 0 2 2 2 2 Galactosyltransferase Actin PF00022.19 PIK33055.1 - 9.4e-72 241.8 0.0 1.1e-71 241.6 0.0 1.0 1 0 0 1 1 1 1 Actin DUF3413 PF11893.8 PIK33056.1 - 0.16 11.1 8.5 0.24 10.5 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) PAZ PF02170.22 PIK33057.1 - 0.0034 17.2 0.6 0.0044 16.8 0.6 1.2 1 0 0 1 1 1 1 PAZ domain NDK PF00334.19 PIK33059.1 - 2.6e-23 82.5 0.0 3.1e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Acyl-CoA_dh_1 PF00441.24 PIK33060.1 - 3.8e-27 95.3 0.0 2.1e-15 57.2 0.0 2.2 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK33060.1 - 1.5e-26 92.5 0.1 2.7e-26 91.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK33060.1 - 3.4e-07 30.9 0.0 9.1e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK33060.1 - 0.0034 17.7 0.0 0.011 16.0 0.0 1.7 1 1 1 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 PIK33060.1 - 0.1 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal CARD PF00619.21 PIK33061.1 - 6.8e-22 77.3 1.4 1.3e-10 41.2 0.0 2.1 2 0 0 2 2 2 2 Caspase recruitment domain CARD_2 PF16739.5 PIK33061.1 - 3.2e-06 27.0 0.2 0.008 16.2 0.0 2.3 2 1 0 2 2 2 2 Caspase recruitment domain MA-Mit PF09245.10 PIK33061.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen ESX-1_EspG PF14011.6 PIK33061.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 EspG family NPL PF17800.1 PIK33062.1 - 1.3e-16 61.0 0.1 3.2e-16 59.8 0.0 1.6 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-H2C2_2 PF13465.6 PIK33063.1 - 6.2e-35 118.1 74.2 9.2e-09 35.4 1.6 9.1 10 0 0 10 10 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK33063.1 - 1.6e-24 84.9 53.4 0.00023 21.5 0.9 6.8 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK33063.1 - 2.5e-18 65.2 61.6 0.00041 21.0 0.9 7.5 8 0 0 8 8 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK33063.1 - 3e-13 49.6 34.1 0.0015 18.8 0.1 7.3 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding HSP20 PF00011.21 PIK33063.1 - 0.0048 17.0 0.2 5 7.3 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family zf-C2H2_6 PF13912.6 PIK33063.1 - 0.0098 15.9 1.9 0.0098 15.9 1.9 7.6 8 0 0 8 8 8 3 C2H2-type zinc finger DUF2515 PF10720.9 PIK33063.1 - 0.014 14.6 0.2 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2515) TAF4 PF05236.14 PIK33063.1 - 0.02 14.7 3.0 3.2 7.4 0.2 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family DUF3268 PF11672.8 PIK33063.1 - 0.072 13.4 0.6 0.072 13.4 0.6 3.6 3 0 0 3 3 3 0 zinc-finger-containing domain PRD PF00874.20 PIK33063.1 - 0.082 13.2 0.0 23 5.4 0.0 2.3 2 0 0 2 2 2 0 PRD domain FixS PF03597.15 PIK33063.1 - 0.31 10.8 1.5 24 4.7 0.1 2.3 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type F-box_4 PF15966.5 PIK33063.1 - 2.5 8.0 7.1 5.5 6.9 0.5 2.9 2 0 0 2 2 2 0 F-box Glyco_transf_49 PF13896.6 PIK33064.1 - 2.9e-22 79.5 0.0 2.6e-15 56.6 0.0 2.0 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 PIK33064.1 - 0.18 11.6 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_49 PF13896.6 PIK33065.1 - 2.2e-13 50.3 0.2 2.7e-13 50.0 0.2 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Snf7 PF03357.21 PIK33066.1 - 2.8e-06 27.0 1.2 3.4e-06 26.7 1.2 1.1 1 0 0 1 1 1 1 Snf7 Sulfotransfer_3 PF13469.6 PIK33067.1 - 6.9e-05 23.3 0.0 9.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Nitroreductase PF00881.24 PIK33070.1 - 0.0053 16.8 0.2 0.0081 16.2 0.2 1.2 1 0 0 1 1 1 1 Nitroreductase family R3H-assoc PF13902.6 PIK33070.1 - 0.01 16.2 1.1 0.015 15.7 1.1 1.2 1 0 0 1 1 1 0 R3H-associated N-terminal domain Peptidase_U57 PF05582.12 PIK33070.1 - 0.04 13.2 1.5 0.051 12.8 1.5 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Ribosomal_S2 PF00318.20 PIK33070.1 - 0.13 11.5 3.2 0.18 11.0 3.2 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 C1q PF00386.21 PIK33071.1 - 1.5e-24 86.6 0.6 1.5e-24 86.6 0.6 1.7 2 0 0 2 2 2 1 C1q domain BclA_C PF18573.1 PIK33071.1 - 0.00064 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 BclA C-terminal domain PHC2_SAM_assoc PF16616.5 PIK33071.1 - 0.0048 17.7 2.7 0.0048 17.7 2.7 1.6 2 0 0 2 2 2 1 Unstructured region on Polyhomeotic-like protein 1 and 2 FAD-SLDH PF12318.8 PIK33071.1 - 0.049 13.7 0.5 0.1 12.7 0.5 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase TNF PF00229.18 PIK33071.1 - 0.16 11.9 0.1 1.7 8.6 0.0 2.4 1 1 1 2 2 2 0 TNF(Tumour Necrosis Factor) family F-box-like PF12937.7 PIK33072.1 - 0.0012 18.7 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like Ribosomal_L15e PF00827.17 PIK33073.1 - 1.3e-88 295.8 7.7 1.5e-88 295.6 7.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 MFS_5 PF05631.14 PIK33074.1 - 1.9e-89 300.1 12.8 2.4e-89 299.7 12.8 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 PIK33074.1 - 2.9e-14 52.8 37.1 2.6e-09 36.5 17.4 3.0 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK33074.1 - 2.4e-06 26.7 2.2 2.4e-06 26.7 2.2 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter GCS PF03074.16 PIK33075.1 - 2.3e-120 402.3 0.2 2.6e-120 402.1 0.2 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF792 PF05632.11 PIK33076.1 - 0.049 13.5 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) GH97_C PF14509.6 PIK33076.1 - 0.069 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation PMG PF05287.12 PIK33077.1 - 2.9 7.9 42.9 1.5 8.9 5.1 5.2 1 1 3 4 4 4 0 PMG protein RVT_1 PF00078.27 PIK33078.1 - 2e-13 50.4 0.2 3.7e-13 49.5 0.2 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.6 PIK33079.1 - 0.0013 18.4 5.7 0.0029 17.3 5.7 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Retrotrans_gag PF03732.17 PIK33079.1 - 0.014 15.6 4.0 0.02 15.2 0.8 2.7 3 1 0 3 3 3 0 Retrotransposon gag protein zf-CCHC PF00098.23 PIK33079.1 - 0.015 15.3 4.1 0.015 15.3 4.1 2.8 3 0 0 3 3 3 0 Zinc knuckle FIBP PF05427.11 PIK33079.1 - 0.016 14.5 0.4 0.025 13.9 0.4 1.3 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) APCDDC PF14921.6 PIK33079.1 - 0.016 14.6 2.0 0.027 13.9 1.5 1.5 1 1 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 Retrotran_gag_2 PF14223.6 PIK33079.1 - 0.16 11.6 2.4 0.15 11.7 0.4 1.9 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type zf-CCHC_2 PF13696.6 PIK33079.1 - 1.2 9.1 4.3 2.5 8.0 4.3 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK33079.1 - 3 7.6 6.7 4.4 7.1 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle CG-1 PF03859.16 PIK33080.1 - 0.095 12.5 0.5 0.36 10.6 0.5 2.0 1 0 0 1 1 1 0 CG-1 domain FMN_dh PF01070.18 PIK33081.1 - 6.2e-76 255.7 0.1 7.8e-76 255.3 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK33081.1 - 1.5e-07 30.8 2.0 1.5e-06 27.5 1.6 2.2 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK33081.1 - 1.8e-05 24.1 0.1 2.5e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 PIK33081.1 - 0.00011 21.7 1.1 0.0071 15.8 0.0 3.0 2 1 1 3 3 3 1 Histidine biosynthesis protein ThiG PF05690.14 PIK33081.1 - 0.0041 16.5 0.2 1.2 8.4 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 PIK33081.1 - 0.06 12.7 0.3 0.12 11.6 0.1 1.6 2 0 0 2 2 2 0 Thiamine monophosphate synthase RimK PF08443.11 PIK33081.1 - 0.078 12.6 0.1 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Dus PF01207.17 PIK33081.1 - 0.094 11.8 0.3 0.22 10.6 0.1 1.6 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) G3P_antiterm PF04309.12 PIK33081.1 - 0.11 11.9 0.3 0.79 9.1 0.0 2.3 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator NMO PF03060.15 PIK33081.1 - 0.11 11.8 0.9 1.1 8.6 1.0 2.1 2 0 0 2 2 2 0 Nitronate monooxygenase DHO_dh PF01180.21 PIK33081.1 - 0.21 10.8 1.1 0.47 9.6 0.1 1.8 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase DUF1866 PF08952.11 PIK33082.1 - 4e-35 120.8 0.0 6.3e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.23 PIK33082.1 - 0.0025 17.4 0.1 0.018 14.6 0.1 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF1866 PF08952.11 PIK33083.1 - 0.0047 16.8 0.0 0.0065 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Pkinase_Tyr PF07714.17 PIK33084.1 - 1.3e-86 290.1 0.0 1.7e-86 289.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK33084.1 - 4e-32 111.6 0.0 5.6e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MFS_1_like PF12832.7 PIK33085.1 - 3.4e-08 32.8 2.0 3.4e-08 32.8 2.0 1.3 2 0 0 2 2 2 1 MFS_1 like family MFS_1 PF07690.16 PIK33085.1 - 4.4e-05 22.6 0.0 4.4e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pkinase PF00069.25 PIK33086.1 - 0.0002 20.9 0.0 0.00037 19.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF2981 PF11200.8 PIK33086.1 - 2.7 7.6 7.1 3.1 7.4 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) MAP70 PF07058.11 PIK33086.1 - 4.8 5.8 15.4 6.6 5.4 15.4 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 OATP PF03137.20 PIK33087.1 - 3.2e-07 29.0 0.8 6.3e-07 28.1 0.1 1.6 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family G-patch PF01585.23 PIK33088.1 - 0.001 18.9 0.1 0.0022 17.8 0.1 1.6 1 0 0 1 1 1 1 G-patch domain PcfK PF14058.6 PIK33088.1 - 0.71 10.2 9.5 0.17 12.2 0.6 2.2 2 0 0 2 2 2 0 PcfK-like protein DUF455 PF04305.14 PIK33089.1 - 1.1e-30 107.0 0.0 1.6e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske_2 PF13806.6 PIK33089.1 - 0.00036 20.4 0.0 0.00069 19.5 0.0 1.5 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Peptidase_S28 PF05577.12 PIK33090.1 - 5.5e-34 117.7 0.0 6.7e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 ZIP4_domain PF18292.1 PIK33092.1 - 1.6e-18 67.2 2.0 1.9e-18 66.9 2.0 1.0 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain SPATA6 PF14909.6 PIK33093.1 - 7.6e-21 74.7 0.0 9.7e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 EphA2_TM PF14575.6 PIK33094.1 - 0.25 12.2 1.5 11 7.0 1.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Comm PF15957.5 PIK33094.1 - 0.86 10.0 6.8 1.6 9.1 6.8 1.4 1 0 0 1 1 1 0 Commissureless BMP2K_C PF15282.6 PIK33096.1 - 0.021 14.7 1.5 0.021 14.7 1.5 3.1 1 1 2 3 3 3 0 BMP-2-inducible protein kinase C-terminus MAP70 PF07058.11 PIK33096.1 - 0.15 10.7 7.1 0.2 10.4 7.1 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 RasGEF PF00617.19 PIK33097.1 - 1.9e-14 54.3 0.4 3.2e-14 53.5 0.1 1.5 2 0 0 2 2 2 1 RasGEF domain Integrin_alpha2 PF08441.12 PIK33098.1 - 6.2e-55 186.9 0.4 1.4e-54 185.7 0.4 1.5 1 1 0 1 1 1 1 Integrin alpha HMG_CoA_synt_N PF01154.17 PIK33099.1 - 2.7e-36 125.1 0.0 3.1e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 PIK33100.1 - 7.2e-89 298.1 0.0 9.1e-89 297.8 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 PIK33100.1 - 6.4e-25 88.0 1.9 1.2e-24 87.2 1.9 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Ank_4 PF13637.6 PIK33101.1 - 3.3e-05 24.3 0.1 6.5e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK33101.1 - 0.00011 22.5 0.1 0.00033 21.0 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 PIK33101.1 - 0.00057 20.4 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) FTCD_N PF07837.12 PIK33102.1 - 1.6e-15 57.3 0.0 2.8e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.14 PIK33103.1 - 0.02 14.9 0.1 8.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Formiminotransferase domain fn3 PF00041.21 PIK33104.1 - 0.00097 19.4 0.1 0.0016 18.7 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Sulfotransfer_3 PF13469.6 PIK33105.1 - 0.0097 16.3 0.0 0.013 15.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Vault_3 PF17795.1 PIK33106.1 - 1.6e-29 101.7 0.1 2.5e-29 101.1 0.1 1.3 1 0 0 1 1 1 1 Major Vault Protein Repeat domain Vault_4 PF17796.1 PIK33106.1 - 4.3e-18 65.1 0.0 1.6e-16 60.1 0.0 2.2 2 0 0 2 2 2 1 Major Vault Protein repeat domain MVP_shoulder PF11978.8 PIK33107.1 - 1.9e-38 131.1 0.5 4.1e-38 130.0 0.5 1.5 1 0 0 1 1 1 1 Shoulder domain DUF2543 PF10820.8 PIK33107.1 - 6.2 7.1 9.0 0.22 11.7 1.0 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF2543) Asp PF00026.23 PIK33108.1 - 8.7e-30 104.2 0.0 1.1e-29 103.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Pannexin_like PF12534.8 PIK33109.1 - 0.013 14.6 0.1 0.013 14.6 0.1 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FtsZ_C PF12327.8 PIK33109.1 - 0.097 13.0 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 FtsZ family, C-terminal domain Mg_trans_NIPA PF05653.14 PIK33110.1 - 1.2e-20 73.8 8.4 1.5e-20 73.6 8.4 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Peptidase_U4 PF03419.13 PIK33110.1 - 0.033 13.5 4.1 0.045 13.0 4.1 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA TssN PF17555.2 PIK33110.1 - 1.5 8.2 12.3 2.2 7.6 12.3 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN CLAMP PF14769.6 PIK33111.1 - 5.5e-07 29.9 1.9 1.9e-06 28.2 1.0 2.3 2 1 0 2 2 2 1 Flagellar C1a complex subunit C1a-32 MecA PF05389.12 PIK33111.1 - 0.017 14.7 1.7 0.017 14.7 1.7 1.6 1 1 1 2 2 2 0 Negative regulator of genetic competence (MecA) WWE PF02825.20 PIK33112.1 - 1.2e-15 57.8 3.3 2.1e-15 57.0 3.3 1.4 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.6 PIK33112.1 - 5.6e-07 29.3 12.3 9.4e-07 28.6 12.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK33112.1 - 3e-06 27.5 12.8 5.1e-06 26.7 12.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK33112.1 - 3.6e-06 26.9 12.7 9.5e-06 25.5 12.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK33112.1 - 3.5e-05 23.9 12.4 7.7e-05 22.8 12.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK33112.1 - 8.6e-05 22.3 12.6 0.00015 21.5 12.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK33112.1 - 0.00032 20.5 13.6 0.00059 19.6 13.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK33112.1 - 0.00077 19.4 12.9 0.0013 18.6 12.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK33112.1 - 0.0075 16.1 13.6 0.023 14.6 13.4 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK33112.1 - 1.3 9.3 11.3 3.7 7.9 11.3 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 PIK33112.1 - 1.7 8.9 10.5 3 8.0 10.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C2H2_4 PF13894.6 PIK33113.1 - 0.05 14.5 3.2 0.2 12.6 2.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger F-box-like PF12937.7 PIK33114.1 - 3.6e-05 23.5 0.0 5.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK33114.1 - 0.026 14.4 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 F-box domain UPRTase PF14681.6 PIK33115.1 - 4.8e-45 153.5 0.0 6.9e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 PIK33115.1 - 2.4e-35 122.1 0.2 3.3e-35 121.6 0.2 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 PIK33116.1 - 1.1e-55 188.4 0.1 1.2e-55 188.2 0.1 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pkinase_Tyr PF07714.17 PIK33117.1 - 1.8e-48 165.1 0.2 7.2e-38 130.3 0.0 1.9 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK33117.1 - 1.2e-15 57.6 0.1 2e-11 43.8 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Ras PF00071.22 PIK33118.1 - 1.2e-19 70.5 0.0 1.4e-19 70.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK33118.1 - 0.062 13.5 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Abhydrolase_1 PF00561.20 PIK33119.1 - 1.6e-07 31.2 0.1 2.8e-07 30.5 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK33119.1 - 2e-05 24.0 0.0 3.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK33119.1 - 0.0064 17.1 0.0 0.009 16.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Asp2 PF16929.5 PIK33119.1 - 0.1 11.6 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Aminotran_5 PF00266.19 PIK33120.1 - 2e-21 76.4 0.0 2.8e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK33120.1 - 3.3e-07 29.8 0.0 5e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 PIK33120.1 - 4.1e-05 23.1 0.0 0.00027 20.3 0.0 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 PIK33120.1 - 4.9e-05 22.0 0.0 9.6e-05 21.1 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 PIK33121.1 - 7.4e-15 54.8 0.0 1e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 PIK33121.1 - 0.23 9.9 0.0 0.42 9.1 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme LOH1CR12 PF10158.9 PIK33122.1 - 0.074 13.1 0.2 0.62 10.1 0.0 2.0 2 0 0 2 2 2 0 Tumour suppressor protein DUF4482 PF14818.6 PIK33122.1 - 0.14 13.0 0.3 0.22 12.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) Dendrin PF15498.6 PIK33123.1 - 0.073 11.8 1.1 0.093 11.5 1.1 1.0 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin LOH1CR12 PF10158.9 PIK33123.1 - 0.14 12.2 0.2 0.97 9.5 0.1 1.9 2 0 0 2 2 2 0 Tumour suppressor protein Kinesin PF00225.23 PIK33124.1 - 6.1e-114 380.4 0.5 6.1e-114 380.4 0.5 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK33124.1 - 2.7e-28 98.8 0.9 4.2e-28 98.1 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 PIK33124.1 - 1.9e-05 24.9 12.0 0.00013 22.2 0.6 3.7 2 1 1 3 3 3 2 Kinesin-associated Yop-YscD_cpl PF16697.5 PIK33124.1 - 0.11 12.8 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain PID PF00640.23 PIK33125.1 - 1.4e-13 51.1 0.6 2e-13 50.6 0.6 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 PIK33125.1 - 6e-05 23.2 0.1 9.4e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Myosin_TH1 PF06017.13 PIK33125.1 - 0.058 13.1 0.1 0.082 12.6 0.1 1.2 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding TMA7 PF09072.10 PIK33126.1 - 1.2e-26 93.3 24.7 1.4e-26 93.1 24.7 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Somatomedin_B PF01033.17 PIK33127.1 - 0.022 15.1 16.9 0.022 15.1 16.9 2.5 2 1 0 2 2 2 0 Somatomedin B domain Peptidase_M14 PF00246.24 PIK33128.1 - 9.7e-31 107.6 0.0 1.3e-30 107.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase 3HBOH PF10605.9 PIK33128.1 - 0.13 10.4 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) Med29 PF11568.8 PIK33129.1 - 1.3e-34 119.4 4.6 1.6e-34 119.1 4.6 1.2 1 0 0 1 1 1 1 Mediator complex subunit 29 GrpE PF01025.19 PIK33129.1 - 0.023 14.3 0.7 0.028 14.1 0.7 1.2 1 0 0 1 1 1 0 GrpE NADH_dhqG_C PF09326.11 PIK33129.1 - 0.024 15.3 2.2 0.074 13.8 0.2 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal SH3BP5 PF05276.14 PIK33129.1 - 0.38 10.5 7.5 0.85 9.4 7.5 1.6 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) NDT80_PhoG PF05224.12 PIK33130.1 - 0.029 14.6 0.5 0.051 13.8 0.5 1.4 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family zf-C3HC4_3 PF13920.6 PIK33132.1 - 7e-07 29.0 5.5 7e-07 29.0 5.5 3.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK33132.1 - 1.7e-05 24.5 8.8 1.7e-05 24.5 8.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK33132.1 - 2.6e-05 24.1 7.7 9.7e-05 22.3 7.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK33132.1 - 0.00021 21.2 7.2 0.00021 21.2 7.2 2.8 2 0 0 2 2 2 1 zinc-RING finger domain PKcGMP_CC PF16808.5 PIK33132.1 - 0.00023 21.0 0.1 0.00023 21.0 0.1 2.1 3 0 0 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Prok-RING_4 PF14447.6 PIK33132.1 - 0.00024 20.9 6.7 0.00024 20.9 6.7 2.8 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-TRAF PF02176.18 PIK33132.1 - 0.0012 19.5 10.1 0.0012 19.5 10.1 3.5 3 1 1 4 4 4 1 TRAF-type zinc finger zf-C3HC4 PF00097.25 PIK33132.1 - 0.0015 18.4 8.8 0.0015 18.4 8.8 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK33132.1 - 0.0018 18.4 6.4 0.0018 18.4 6.4 2.5 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 PIK33132.1 - 0.0047 16.8 1.0 0.0047 16.8 1.0 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Sina PF03145.16 PIK33132.1 - 0.0077 16.2 11.9 0.041 13.8 0.7 2.4 1 1 1 2 2 2 2 Seven in absentia protein family DUF641 PF04859.12 PIK33132.1 - 0.012 16.0 0.1 0.017 15.4 0.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) HSBP1 PF06825.12 PIK33132.1 - 0.05 13.5 0.5 0.11 12.4 0.5 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 SlyX PF04102.12 PIK33132.1 - 0.082 13.5 0.2 0.15 12.7 0.2 1.3 1 0 0 1 1 1 0 SlyX DUF1664 PF07889.12 PIK33132.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 PIK33132.1 - 0.11 12.5 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-TRAF_2 PF15965.5 PIK33132.1 - 0.17 12.4 19.5 0.072 13.6 2.0 3.2 1 1 2 3 3 3 0 TRAF-like zinc-finger zf-C2H2_jaz PF12171.8 PIK33132.1 - 0.29 11.4 0.3 0.29 11.4 0.3 3.7 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding eIF-3_zeta PF05091.12 PIK33134.1 - 1.9e-39 136.1 4.6 9.7e-39 133.7 4.6 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4298 PF14131.6 PIK33134.1 - 0.044 13.7 2.1 0.98 9.4 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) DUF2373 PF10180.9 PIK33135.1 - 2.7e-10 39.9 1.0 5.7e-10 38.9 1.0 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Glyco_transf_29 PF00777.18 PIK33136.1 - 4.1e-27 95.3 0.1 4.6e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Septin PF00735.18 PIK33136.1 - 0.092 12.0 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Septin Peptidase_M13_N PF05649.13 PIK33137.1 - 4.6e-28 99.0 0.0 5.7e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 PIK33138.1 - 1.4e-55 189.5 0.0 2e-55 189.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK33138.1 - 4e-06 26.6 1.3 4e-06 26.6 1.3 1.6 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK33139.1 - 3.8e-27 95.2 0.0 4.2e-27 95.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M13 Sua5_yciO_yrdC PF01300.18 PIK33140.1 - 3.3e-22 78.8 0.4 3.2e-15 56.1 0.1 2.2 1 1 1 2 2 2 2 Telomere recombination Methyltransf_3 PF01596.17 PIK33140.1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Pkinase PF00069.25 PIK33141.1 - 1.5e-57 194.9 0.0 1.9e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK33141.1 - 2.9e-34 118.5 0.3 6.1e-34 117.5 0.3 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK33141.1 - 2.9e-08 34.0 0.3 1.9e-06 28.0 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK33141.1 - 1.8e-06 27.2 1.3 1.2e-05 24.4 0.3 2.0 1 1 1 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 PIK33141.1 - 2.3e-06 27.1 0.6 4.3e-06 26.2 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK33141.1 - 1.7e-05 24.3 0.0 4.2e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 PIK33141.1 - 5.5e-05 22.8 0.3 8.4e-05 22.3 0.3 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 PIK33141.1 - 0.0019 17.0 0.0 0.0028 16.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 PIK33141.1 - 0.0024 17.5 0.1 0.0041 16.7 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase IHABP4_N PF16174.5 PIK33143.1 - 0.00028 21.6 3.4 0.00028 21.6 3.4 1.7 2 0 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal DUF5039 PF16442.5 PIK33143.1 - 0.0068 16.0 0.9 0.01 15.4 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5039) MRNIP PF15749.5 PIK33143.1 - 0.0083 16.8 1.6 0.018 15.7 1.6 1.5 1 0 0 1 1 1 1 MRN-interacting protein Peptidase_S49_N PF08496.10 PIK33143.1 - 0.19 11.8 2.1 0.45 10.6 2.1 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF809 PF05663.11 PIK33143.1 - 4.6 7.4 7.5 7.6 6.7 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) WD40 PF00400.32 PIK33144.1 - 2.7e-12 47.0 5.3 9.9e-05 23.0 0.0 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 PIK33144.1 - 0.0094 14.6 1.6 0.052 12.2 0.3 2.4 1 1 0 2 2 2 1 Nucleoporin Nup120/160 eIF-1a PF01176.19 PIK33145.1 - 3.7e-09 36.3 2.4 2.2e-07 30.6 0.3 2.5 2 1 0 2 2 2 1 Translation initiation factor 1A / IF-1 Pkinase_Tyr PF07714.17 PIK33146.1 - 1.3e-07 31.2 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK33146.1 - 0.001 18.5 0.1 0.0021 17.5 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain UCH PF00443.29 PIK33147.1 - 9.1e-22 77.8 0.7 1.8e-18 67.0 0.1 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase rve PF00665.26 PIK33147.1 - 5.2e-16 58.9 0.0 9.9e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain UCH_1 PF13423.6 PIK33147.1 - 5.3e-09 36.1 0.2 1.5e-08 34.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase rve_3 PF13683.6 PIK33147.1 - 0.00024 20.8 0.0 0.00074 19.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain ADK_lid PF05191.14 PIK33147.1 - 0.77 9.8 6.0 6.7 6.8 2.7 3.4 2 1 1 3 3 3 0 Adenylate kinase, active site lid Sec5 PF15469.6 PIK33151.1 - 0.0085 15.9 0.4 0.02 14.7 0.4 1.7 1 1 0 1 1 1 1 Exocyst complex component Sec5 DUF3361 PF11841.8 PIK33151.1 - 0.044 13.7 6.2 0.23 11.4 6.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) LemA PF04011.12 PIK33151.1 - 0.067 13.1 0.6 0.21 11.4 0.2 1.9 2 0 0 2 2 2 0 LemA family I_LWEQ PF01608.17 PIK33151.1 - 0.085 13.1 2.1 1.2 9.3 0.6 2.1 1 1 1 2 2 2 0 I/LWEQ domain Baculo_PEP_C PF04513.12 PIK33151.1 - 0.15 12.1 3.5 0.097 12.7 0.6 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PDZ PF00595.24 PIK33152.1 - 8.7e-17 61.3 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK33152.1 - 1.3e-11 44.2 0.0 1.7e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK33152.1 - 0.00018 21.8 0.0 0.00021 21.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Ank_2 PF12796.7 PIK33153.1 - 9.9e-19 67.7 2.1 1e-11 45.3 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK33153.1 - 1e-18 67.4 0.0 1.1e-06 29.0 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK33153.1 - 2.5e-16 59.5 0.1 2.9e-09 37.0 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK33153.1 - 1.7e-14 53.5 0.1 4.5e-05 23.7 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK33153.1 - 1.9e-11 43.1 0.0 0.024 15.1 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat SIS PF01380.22 PIK33153.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 SIS domain RUN PF02759.19 PIK33154.1 - 6e-14 52.1 0.1 9.9e-13 48.2 0.0 2.5 2 0 0 2 2 2 1 RUN domain SesA PF17107.5 PIK33155.1 - 0.0057 16.8 1.6 0.0086 16.3 0.6 1.7 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases G10 PF01125.17 PIK33155.1 - 0.12 12.1 0.2 0.12 12.1 0.2 1.9 2 0 0 2 2 2 0 G10 protein SlyX PF04102.12 PIK33155.1 - 8.8 7.0 8.3 18 6.1 6.6 2.4 2 1 0 2 2 2 0 SlyX TMEM232 PF15877.5 PIK33156.1 - 4.1e-28 98.6 8.0 2.6e-26 92.7 0.2 2.4 3 0 0 3 3 3 2 Transmembrane protein family 232 DUF1977 PF09320.11 PIK33156.1 - 0.31 11.3 7.2 0.88 9.9 7.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) EMC3_TMCO1 PF01956.16 PIK33156.1 - 2.4 7.9 4.1 4.6 6.9 4.1 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RR_TM4-6 PF06459.12 PIK33156.1 - 3 7.6 12.3 7.6 6.3 12.3 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAA_11 PF13086.6 PIK33156.1 - 5.9 6.6 10.8 11 5.7 10.8 1.3 1 0 0 1 1 1 0 AAA domain BNR_3 PF13859.6 PIK33157.1 - 0.091 12.0 0.2 0.18 11.0 0.0 1.5 2 0 0 2 2 2 0 BNR repeat-like domain Ldl_recept_a PF00057.18 PIK33158.1 - 8.4e-19 67.5 43.4 6.9e-07 29.4 11.3 4.3 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A VDE PF07137.11 PIK33158.1 - 0.47 9.9 8.4 0.9 9.0 8.4 1.4 1 0 0 1 1 1 0 VDE lipocalin domain RAMA PF18755.1 PIK33159.1 - 4.8e-30 104.2 0.0 6.5e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated FXR_C1 PF16096.5 PIK33159.1 - 0.028 14.6 0.1 0.054 13.7 0.1 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 CSN8_PSD8_EIF3K PF10075.9 PIK33160.1 - 1.1e-36 126.0 0.1 1.5e-36 125.6 0.1 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 PIK33160.1 - 0.041 14.4 0.0 0.065 13.8 0.0 1.3 1 0 0 1 1 1 0 PCI domain Alk_phosphatase PF00245.20 PIK33162.1 - 5e-94 315.6 0.4 7.7e-94 315.0 0.4 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 PIK33162.1 - 2.5e-07 30.3 0.3 4.7e-07 29.4 0.1 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily Phosphodiest PF01663.22 PIK33162.1 - 0.00013 21.7 0.1 0.00014 21.5 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Phage_integrase PF00589.22 PIK33163.1 - 0.0095 15.7 0.0 0.023 14.5 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 PIK33165.1 - 0.00013 22.2 0.8 0.00036 20.8 0.1 2.0 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK33165.1 - 0.00074 19.9 0.0 0.0014 19.1 0.0 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain rve PF00665.26 PIK33167.1 - 5.5e-08 33.0 0.0 9.1e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 PIK33168.1 - 0.08 13.6 0.1 0.48 11.1 0.0 2.2 2 0 0 2 2 2 0 Aspartyl protease zf-CCHC_5 PF14787.6 PIK33168.1 - 0.34 10.6 5.1 1.1 9.1 5.1 1.9 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 PIK33168.1 - 2.2 8.5 4.4 0.81 9.9 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 PIK33169.1 - 0.08 12.4 0.0 0.21 11.1 0.0 1.6 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK33170.1 - 5.5e-13 49.2 0.0 8.4e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK33170.1 - 0.0015 18.6 0.4 0.0015 18.6 0.4 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33170.1 - 0.016 15.4 0.1 0.027 14.7 0.1 1.4 1 0 0 1 1 1 0 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK33170.1 - 0.023 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 DDE domain Exo_endo_phos_2 PF14529.6 PIK33172.1 - 0.01 15.6 0.9 0.88 9.4 0.1 2.7 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase Blt1 PF12754.7 PIK33172.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain Death PF00531.22 PIK33173.1 - 6.4e-12 45.5 1.8 8.8e-12 45.0 1.8 1.2 1 0 0 1 1 1 1 Death domain DUF2390 PF09523.10 PIK33173.1 - 0.056 13.8 0.4 5.6 7.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2390) SurA_N_3 PF13624.6 PIK33173.1 - 0.058 13.2 0.5 0.067 13.0 0.5 1.1 1 0 0 1 1 1 0 SurA N-terminal domain CARD_2 PF16739.5 PIK33173.1 - 0.58 10.2 4.2 0.14 12.1 0.9 1.7 2 0 0 2 2 2 0 Caspase recruitment domain Ras PF00071.22 PIK33174.1 - 2.7e-14 53.1 0.1 3.5e-14 52.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Xpo1 PF08389.12 PIK33175.1 - 1.4e-19 70.6 0.2 8.6e-18 64.8 0.0 3.6 4 0 0 4 4 4 1 Exportin 1-like protein BRK PF07533.16 PIK33175.1 - 0.07 12.8 0.1 0.2 11.3 0.1 1.8 1 0 0 1 1 1 0 BRK domain SAG PF04092.13 PIK33176.1 - 0.00018 22.3 0.5 0.11 13.3 0.1 2.3 2 0 0 2 2 2 2 SRS domain Got1 PF04178.12 PIK33177.1 - 5.1e-38 130.0 15.7 7.8e-38 129.4 15.7 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family Oxidored_q2 PF00420.24 PIK33177.1 - 0.2 11.3 3.2 11 5.7 0.0 2.4 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DNA_pol_A_exo1 PF01612.20 PIK33178.1 - 4e-46 156.9 0.3 6.7e-46 156.2 0.3 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 PIK33178.1 - 1.2e-14 54.8 0.0 3.2e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 PIK33178.1 - 1.4e-14 53.8 0.0 1.3e-11 44.3 0.0 2.6 1 1 1 2 2 2 2 HRDC domain dsrm PF00035.26 PIK33179.1 - 0.0035 18.0 0.0 0.0072 17.0 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif PI3Ka PF00613.20 PIK33180.1 - 6.1e-23 81.2 0.0 1.5e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 PIK33180.1 - 2.7e-05 24.1 0.0 8.4e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Ipi1_N PF12333.8 PIK33180.1 - 0.072 13.7 0.5 0.42 11.2 0.2 2.4 1 1 1 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Peptidase_M17 PF00883.21 PIK33182.1 - 5.7e-79 265.6 0.6 3.7e-35 121.7 0.0 3.3 2 1 1 3 3 3 3 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 PIK33182.1 - 5.3e-18 65.1 0.3 1.1e-17 64.1 0.3 1.5 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain PDZ_2 PF13180.6 PIK33182.1 - 0.16 12.3 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 PIK33183.1 - 2.1e-30 104.9 3.8 2.7e-17 62.9 0.2 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK33183.1 - 1.1e-17 63.6 0.0 7.2e-09 35.4 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK33183.1 - 4.1e-09 36.7 0.1 0.0039 17.5 0.0 2.6 2 0 0 2 2 2 2 PDZ domain CCM2_C PF16545.5 PIK33183.1 - 0.014 16.0 0.0 0.026 15.0 0.0 1.4 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology PDZ PF00595.24 PIK33184.1 - 5.4e-11 42.7 0.0 1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK33184.1 - 0.0076 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain DUF3654 PF12376.8 PIK33186.1 - 0.07 13.3 0.6 0.12 12.5 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) Plasmod_Pvs28 PF06247.11 PIK33187.1 - 0.00047 20.4 2.0 0.00047 20.4 2.0 3.8 3 1 1 4 4 4 1 Pvs28 EGF domain EGF_CA PF07645.15 PIK33187.1 - 0.022 15.0 33.3 0.7 10.1 6.6 3.3 3 0 0 3 3 3 0 Calcium-binding EGF domain TIL PF01826.17 PIK33187.1 - 0.042 14.1 28.2 0.24 11.7 4.3 3.4 1 1 2 3 3 3 0 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK33187.1 - 3 8.1 28.1 0.59 10.4 5.8 3.4 3 0 0 3 3 3 0 EGF domain EGF_2 PF07974.13 PIK33188.1 - 0.0048 17.2 2.7 0.011 16.0 2.7 1.7 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 PIK33188.1 - 0.013 15.8 2.0 0.013 15.8 2.0 1.8 2 0 0 2 2 2 0 EGF-like domain WBP-1 PF11669.8 PIK33188.1 - 0.022 15.4 0.1 0.063 13.9 0.0 1.9 2 0 0 2 2 2 0 WW domain-binding protein 1 EphA2_TM PF14575.6 PIK33188.1 - 0.099 13.5 1.1 0.2 12.5 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain hEGF PF12661.7 PIK33188.1 - 0.13 12.9 4.2 0.34 11.6 4.2 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Fis1_TPR_C PF14853.6 PIK33189.1 - 0.00036 20.5 0.5 0.00073 19.6 0.5 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Peptidase_M1 PF01433.20 PIK33190.1 - 9.4e-13 48.2 0.0 1.6e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 PIK33190.1 - 9.7e-11 41.7 0.0 2.8e-10 40.3 0.0 1.7 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Thioredoxin PF00085.20 PIK33191.1 - 6.5e-30 103.2 0.1 6.8e-30 103.1 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 PIK33191.1 - 2.4e-07 31.0 0.0 3e-07 30.7 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 PIK33191.1 - 2.5e-07 30.6 0.1 6.2e-07 29.4 0.0 1.5 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 PIK33191.1 - 6.8e-06 26.5 0.1 1.7e-05 25.2 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 PIK33191.1 - 4.1e-05 23.7 0.1 8.3e-05 22.7 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 PIK33191.1 - 0.00015 21.5 0.0 0.00018 21.3 0.0 1.2 1 1 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 PIK33191.1 - 0.00022 21.0 0.0 0.00022 21.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 PIK33191.1 - 0.00031 20.2 0.0 0.00037 19.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 PIK33191.1 - 0.0041 17.0 0.0 0.005 16.7 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein gpW PF02831.15 PIK33191.1 - 0.044 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 gpW Phosducin PF02114.16 PIK33191.1 - 0.082 11.8 0.0 0.1 11.5 0.0 1.0 1 0 0 1 1 1 0 Phosducin ZU5 PF00791.20 PIK33192.1 - 0.00066 20.0 0.0 0.0024 18.2 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain Peptidase_M14 PF00246.24 PIK33193.1 - 3.2e-18 66.5 0.1 3.7e-18 66.3 0.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Peptidase_M14 PF00246.24 PIK33194.1 - 1.6e-06 28.2 0.0 1.9e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase TERB2 PF15101.6 PIK33194.1 - 0.31 11.1 1.3 0.55 10.3 1.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 zf-C2H2 PF00096.26 PIK33195.1 - 4.7e-23 80.3 43.5 4.5e-06 26.8 4.0 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK33195.1 - 3.1e-19 68.5 42.0 0.00011 22.5 0.1 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK33195.1 - 6.8e-18 63.8 38.8 0.0017 19.0 0.6 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK33195.1 - 1.4e-11 44.0 35.0 0.00074 19.5 3.9 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK33195.1 - 1.7e-09 37.7 27.1 0.049 13.9 0.2 5.5 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 PIK33195.1 - 0.00056 19.9 11.9 0.9 9.6 0.1 5.1 5 0 0 5 5 5 1 XPA protein N-terminal Zn-ribbon_8 PF09723.10 PIK33195.1 - 0.00094 19.3 19.6 0.77 9.9 2.6 4.5 3 2 1 4 4 4 2 Zinc ribbon domain zf-C2H2_9 PF16293.5 PIK33195.1 - 0.0014 18.4 9.7 0.26 11.2 0.1 4.2 3 1 1 4 4 4 1 C2H2 type zinc-finger (1 copy) zf_UBZ PF18439.1 PIK33195.1 - 0.0055 16.3 15.6 0.075 12.6 0.1 5.2 5 0 0 5 5 5 1 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 PIK33195.1 - 0.007 16.1 2.3 0.1 12.4 0.3 4.3 4 0 0 4 4 4 2 zinc-finger C2H2-type C1_1 PF00130.22 PIK33195.1 - 0.0085 16.0 23.4 0.25 11.3 5.9 4.1 2 2 1 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Sec23_Sec24 PF04810.15 PIK33195.1 - 0.015 15.4 13.2 3.5 7.8 2.4 4.7 4 1 0 4 4 4 0 Sec23/Sec24 zinc finger zf-Di19 PF05605.12 PIK33195.1 - 0.015 15.6 24.2 0.084 13.2 4.6 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.7 PIK33195.1 - 0.021 14.8 1.6 0.021 14.8 1.6 3.4 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zinc_ribbon_15 PF17032.5 PIK33195.1 - 0.031 15.0 16.8 0.46 11.3 3.1 3.4 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 PIK33195.1 - 0.06 14.0 20.0 0.52 11.0 0.5 4.3 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats CpXC PF14353.6 PIK33195.1 - 0.079 13.0 0.3 0.079 13.0 0.3 4.2 1 1 4 5 5 5 0 CpXC protein Rep_fac-A_C PF08646.10 PIK33195.1 - 0.081 12.7 12.9 1.7 8.4 0.5 3.7 1 1 0 3 3 3 0 Replication factor-A C terminal domain zf-met PF12874.7 PIK33195.1 - 0.089 13.2 26.3 1.6 9.2 1.5 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type ADK_lid PF05191.14 PIK33195.1 - 0.13 12.3 20.4 1.3 9.0 7.5 3.9 2 2 1 3 3 3 0 Adenylate kinase, active site lid TF_Zn_Ribbon PF08271.12 PIK33195.1 - 0.16 11.5 11.6 2 8.0 0.0 4.9 5 0 0 5 5 5 0 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 PIK33195.1 - 0.17 11.8 0.1 0.17 11.8 0.1 4.2 3 2 2 5 5 4 0 Putative transposase DNA-binding domain Zn_ribbon_SprT PF17283.2 PIK33195.1 - 0.19 11.7 19.5 0.53 10.2 0.8 4.1 3 1 1 4 4 4 0 SprT-like zinc ribbon domain YhfH PF14149.6 PIK33195.1 - 0.21 11.6 9.5 7.4 6.6 0.2 4.3 4 0 0 4 4 4 0 YhfH-like protein zinc_ribbon_9 PF14369.6 PIK33195.1 - 0.21 11.8 12.3 7 7.0 0.1 4.6 4 1 1 5 5 5 0 zinc-ribbon GAGA PF09237.11 PIK33195.1 - 0.28 11.0 7.5 6 6.8 0.0 4.0 2 1 2 4 4 4 0 GAGA factor DZR PF12773.7 PIK33195.1 - 0.36 10.9 18.6 1.7e+03 -0.9 18.6 3.3 1 1 0 1 1 1 0 Double zinc ribbon PRP21_like_P PF12230.8 PIK33195.1 - 0.42 10.5 7.7 0.1 12.5 0.4 2.8 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein BolA PF01722.18 PIK33195.1 - 0.44 10.9 5.4 13 6.1 1.0 3.0 3 1 0 3 3 2 0 BolA-like protein zf-MYST PF17772.1 PIK33195.1 - 0.46 10.1 16.3 0.62 9.7 0.3 4.6 2 2 3 5 5 5 0 MYST family zinc finger domain Acetone_carb_G PF08882.11 PIK33195.1 - 0.84 9.8 3.7 7.7 6.7 0.0 2.9 1 1 2 3 3 3 0 Acetone carboxylase gamma subunit Zf_RING PF16744.5 PIK33195.1 - 1.1 9.5 16.1 0.21 11.7 1.2 3.9 1 1 3 4 4 4 0 KIAA1045 RING finger FYVE PF01363.21 PIK33195.1 - 1.2 9.4 23.8 13 6.1 1.4 3.5 1 1 1 2 2 1 0 FYVE zinc finger zf-AN1 PF01428.16 PIK33195.1 - 1.2 9.3 23.3 8.7 6.6 0.2 5.3 4 1 1 5 5 5 0 AN1-like Zinc finger zf-trcl PF13451.6 PIK33195.1 - 1.4 8.9 18.8 3.7 7.5 0.2 5.1 4 1 0 4 4 4 0 Probable zinc-ribbon domain zf_ZIC PF18366.1 PIK33195.1 - 2.9 8.0 14.1 21 5.3 0.1 4.1 3 1 1 4 4 4 0 Zic proteins zinc finger domain zf_C2H2_13 PF18508.1 PIK33195.1 - 3.1 7.5 9.1 83 2.9 0.1 4.2 3 1 1 4 4 4 0 Zinc finger domain zf-C2H2_2 PF12756.7 PIK33195.1 - 5.6 7.4 26.6 11 6.4 0.1 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) WD40 PF00400.32 PIK33196.1 - 1.4e-13 51.0 3.3 0.22 12.5 0.7 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK33196.1 - 1.1e-09 38.4 0.0 7.1e-05 23.0 0.0 3.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 PIK33196.1 - 0.0098 15.6 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 2 TUP1-like enhancer of split PikAIV_N PF18605.1 PIK33196.1 - 0.031 13.9 1.7 0.056 13.0 1.7 1.4 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Ge1_WD40 PF16529.5 PIK33196.1 - 0.043 12.8 0.0 0.9 8.4 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cep57_CLD_2 PF14197.6 PIK33196.1 - 0.1 12.7 2.3 0.18 11.9 2.3 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 7tm_1 PF00001.21 PIK33197.1 - 5.6e-63 212.7 17.4 7.2e-63 212.4 17.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK33197.1 - 8.6e-11 42.0 10.0 8.6e-11 42.0 10.0 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx zf-LITAF-like PF10601.9 PIK33197.1 - 1 9.7 6.5 0.11 12.8 0.8 2.4 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain LapA_dom PF06305.11 PIK33197.1 - 1.3 8.8 0.0 1.3 8.8 0.0 4.1 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Sulfotransfer_1 PF00685.27 PIK33198.1 - 3.2e-15 56.3 0.0 6.3e-15 55.4 0.0 1.5 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK33198.1 - 6.1e-09 36.6 0.0 0.00011 22.6 0.0 2.7 2 1 1 3 3 3 2 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK33199.1 - 0.039 14.3 0.0 0.093 13.1 0.0 1.6 1 1 0 1 1 1 0 Sulfotransferase family zf-met PF12874.7 PIK33200.1 - 4.5e-07 30.0 0.9 4.5e-07 30.0 0.9 7.0 8 0 0 8 8 8 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK33200.1 - 2.8e-05 24.3 1.3 2.8e-05 24.3 1.3 6.3 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 PIK33200.1 - 0.00023 21.4 1.1 0.00023 21.4 1.1 8.0 9 1 0 9 9 9 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK33200.1 - 0.002 18.8 10.8 0.01 16.6 1.2 9.3 9 1 1 10 10 10 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK33200.1 - 0.0027 18.1 2.5 0.0027 18.1 2.5 8.5 8 1 1 9 9 9 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 PIK33200.1 - 0.0049 16.6 0.7 0.0049 16.6 0.7 6.7 9 0 0 9 9 9 1 C2H2-type zinc-finger domain ROS_MUCR PF05443.11 PIK33200.1 - 0.19 11.8 5.6 0.5 10.4 0.1 2.7 3 0 0 3 3 3 0 ROS/MUCR transcriptional regulator protein PyrI_C PF02748.15 PIK33200.1 - 2.4 8.1 18.3 14 5.7 0.5 4.9 2 1 2 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Promethin PF16015.5 PIK33201.1 - 6.3 6.8 18.0 0.037 13.9 4.2 2.6 2 0 0 2 2 2 0 Promethin DUF3767 PF12597.8 PIK33202.1 - 0.15 11.9 1.0 1.6 8.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) Bcl-2 PF00452.19 PIK33203.1 - 1.5e-14 54.5 1.7 3.3e-14 53.4 1.0 1.9 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family Arc_PepC_II PF06847.11 PIK33203.1 - 0.088 13.3 0.3 0.31 11.6 0.1 1.9 1 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Atrophin-1 PF03154.15 PIK33203.1 - 0.24 9.7 0.6 0.3 9.3 0.6 1.0 1 0 0 1 1 1 0 Atrophin-1 family Integrin_alpha2 PF08441.12 PIK33204.1 - 1.3e-64 218.8 0.3 8.7e-38 130.4 1.5 2.4 1 1 1 2 2 2 2 Integrin alpha FG-GAP PF01839.23 PIK33204.1 - 8.9e-18 64.1 16.5 2.4e-08 33.9 0.5 3.5 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.6 PIK33204.1 - 5.6e-07 30.0 9.6 7e-06 26.5 2.6 3.2 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK33204.1 - 0.005 17.1 4.8 0.0099 16.1 0.5 2.7 2 0 0 2 2 2 1 FG-GAP repeat LYRIC PF15686.5 PIK33204.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF2207 PF09972.9 PIK33204.1 - 0.023 13.5 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Integrin_alpha PF00357.20 PIK33204.1 - 0.048 13.7 0.5 0.13 12.3 0.5 1.8 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region SIT PF15330.6 PIK33204.1 - 0.084 13.3 0.2 0.91 10.0 0.0 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF3319 PF11782.8 PIK33205.1 - 0.076 13.0 0.0 0.076 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) HIT PF01230.23 PIK33206.1 - 9e-20 71.2 0.0 1.3e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 PIK33206.1 - 7.7e-18 65.0 0.0 1e-17 64.6 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-H2C2_2 PF13465.6 PIK33207.1 - 9.9e-13 47.9 12.0 9.5e-07 29.0 0.3 3.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK33207.1 - 6.3e-08 32.7 21.2 0.00032 21.0 1.4 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type NPL PF17800.1 PIK33207.1 - 2.3e-07 31.3 1.3 4e-07 30.5 0.3 1.9 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-C2H2_4 PF13894.6 PIK33207.1 - 2.9e-06 27.6 22.6 0.035 14.9 1.7 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK33207.1 - 0.036 14.3 0.9 0.036 14.3 0.9 3.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK33207.1 - 0.092 12.7 5.2 12 5.8 0.1 3.5 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 PIK33207.1 - 0.4 10.8 13.5 2.9 8.0 2.2 3.6 1 1 2 3 3 3 0 BED zinc finger zf-Di19 PF05605.12 PIK33207.1 - 1.9 8.8 8.9 4.3 7.7 1.2 3.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Yippee-Mis18 PF03226.14 PIK33207.1 - 5.5 7.3 8.9 2.1 8.6 4.9 2.2 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ion_trans_2 PF07885.16 PIK33208.1 - 2.6e-22 78.6 12.5 4.3e-13 49.0 6.6 2.4 2 0 0 2 2 2 2 Ion channel DUF3267 PF11667.8 PIK33208.1 - 0.022 15.1 6.2 0.023 15.0 0.3 2.3 1 1 0 2 2 2 0 Putative zincin peptidase FBA PF04300.13 PIK33209.1 - 5.5e-36 123.9 2.7 5.7e-25 88.0 0.3 2.3 1 1 1 2 2 2 2 F-box associated region F-box-like PF12937.7 PIK33209.1 - 6.5e-07 29.2 0.1 1.6e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK33209.1 - 6.7e-07 29.0 2.0 8.1e-07 28.8 0.7 1.9 2 0 0 2 2 2 1 F-box domain 7tm_1 PF00001.21 PIK33210.1 - 3.5e-22 79.0 5.7 5.1e-22 78.5 5.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK33210.1 - 2.6e-05 23.7 3.4 8e-05 22.1 3.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK33210.1 - 3.4e-05 23.6 2.1 3.4e-05 23.6 2.1 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MMM1 PF10296.9 PIK33210.1 - 0.063 12.3 0.1 0.087 11.9 0.1 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Rb_C PF08934.10 PIK33211.1 - 1.5e-05 24.9 2.8 2.2e-05 24.3 2.8 1.3 1 0 0 1 1 1 1 Rb C-terminal domain RB_B PF01857.20 PIK33211.1 - 0.00036 20.6 0.0 0.00073 19.6 0.0 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain DUF1400 PF07176.11 PIK33211.1 - 0.099 12.9 0.1 0.38 11.0 0.1 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) DUF4083 PF13314.6 PIK33211.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) RB_A PF01858.17 PIK33212.1 - 1.2e-73 247.2 0.4 8.3e-72 241.2 0.0 2.3 2 0 0 2 2 2 2 Retinoblastoma-associated protein A domain RB_B PF01857.20 PIK33212.1 - 4.8e-43 146.3 0.8 1.2e-42 145.1 0.8 1.7 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 PIK33212.1 - 3e-30 104.5 0.1 1.2e-29 102.6 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3452) CxC1 PF18802.1 PIK33213.1 - 7.6e-09 35.7 5.7 2.1e-08 34.3 1.3 2.3 1 1 1 2 2 2 2 CxC1 like cysteine cluster associated with KDZ transposases CxC2 PF18803.1 PIK33213.1 - 4.4e-07 30.0 2.0 1.1e-06 28.7 1.7 1.8 1 1 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK33213.1 - 0.0017 18.1 3.1 0.0017 18.1 3.1 2.2 2 1 1 3 3 3 1 CxC3 like cysteine cluster associated with KDZ transposases Fibrinogen_C PF00147.18 PIK33214.1 - 4.3e-10 39.8 0.0 7.5e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK33214.1 - 3.1e-06 27.3 9.1 3.1e-06 27.3 9.1 4.1 2 2 1 3 3 3 1 EGF domain TILa PF12714.7 PIK33214.1 - 6.8e-05 22.7 5.2 6.8e-05 22.7 5.2 4.1 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK33214.1 - 0.0016 18.6 12.2 0.0016 18.6 12.2 3.2 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK33214.1 - 0.84 10.1 26.4 2.5 8.5 10.1 4.3 3 2 0 3 3 3 0 EGF-like domain EB PF01683.18 PIK33214.1 - 4.6 7.6 32.1 1.5e+02 2.8 16.8 3.7 1 1 1 2 2 2 0 EB module C2-set_2 PF08205.12 PIK33215.1 - 0.00033 20.7 4.1 0.0025 17.9 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK33215.1 - 0.0021 18.2 5.5 1.2 9.4 0.3 3.9 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK33215.1 - 0.0041 17.4 9.0 0.27 11.6 0.0 4.0 3 1 1 4 4 4 2 Immunoglobulin domain Cwf_Cwc_15 PF04889.12 PIK33215.1 - 0.0093 15.7 28.5 0.016 14.9 28.5 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Protocadherin PF08374.11 PIK33215.1 - 0.013 15.4 0.5 0.038 14.0 0.1 2.0 1 1 0 1 1 1 0 Protocadherin PPP4R2 PF09184.11 PIK33215.1 - 0.023 14.3 19.6 0.037 13.6 19.6 1.3 1 0 0 1 1 1 0 PPP4R2 Shisa PF13908.6 PIK33215.1 - 0.062 13.5 0.8 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator TFB6 PF17110.5 PIK33215.1 - 0.18 11.6 10.7 0.34 10.6 10.7 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CNDH2_C PF16858.5 PIK33215.1 - 0.34 10.7 6.7 0.53 10.1 6.7 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NOA36 PF06524.12 PIK33215.1 - 0.87 8.9 33.6 1.7 7.9 33.6 1.4 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 PIK33215.1 - 1.2 9.3 25.3 2.2 8.5 25.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 PIK33215.1 - 1.9 8.5 16.0 3.8 7.5 16.0 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal SDA1 PF05285.12 PIK33215.1 - 2 7.7 21.3 3.3 7.0 21.3 1.3 1 0 0 1 1 1 0 SDA1 Rhabdo_ncap PF00945.18 PIK33215.1 - 5.8 5.7 9.9 9.1 5.0 9.9 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF2457 PF10446.9 PIK33215.1 - 9.3 5.3 39.3 15 4.6 39.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TMEM154 PF15102.6 PIK33216.1 - 0.022 14.7 0.7 0.056 13.4 0.7 1.6 1 0 0 1 1 1 0 TMEM154 protein family TssO PF17561.2 PIK33216.1 - 0.05 13.7 1.0 0.086 12.9 1.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO Sarcoglycan_2 PF05510.13 PIK33216.1 - 0.086 11.6 0.2 0.13 11.0 0.2 1.2 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Tir_receptor_M PF03549.14 PIK33216.1 - 0.3 11.4 1.3 6.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) intimin-binding domain Sigma_reg_N PF13800.6 PIK33216.1 - 0.33 11.3 2.8 1.6 9.0 2.0 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Flp1_like PF16982.5 PIK33216.1 - 0.99 8.8 3.9 2.3 7.7 3.9 1.6 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain Med12-LCEWAV PF12145.8 PIK33217.1 - 7.9e-121 404.2 0.6 1.3e-120 403.5 0.6 1.3 1 0 0 1 1 1 1 Eukaryotic Mediator 12 subunit domain TPR_19 PF14559.6 PIK33219.1 - 0.00023 21.6 0.6 8.2 7.0 0.0 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat NinG PF05766.12 PIK33219.1 - 0.016 15.2 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein TPR_16 PF13432.6 PIK33219.1 - 0.021 15.5 1.9 0.74 10.5 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK33219.1 - 0.061 14.2 2.0 24 6.1 0.0 4.8 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK33219.1 - 0.49 11.1 12.2 11 6.9 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK33219.1 - 1.1 9.6 10.9 20 5.6 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Peptidase_M29 PF02073.15 PIK33220.1 - 0.06 12.1 0.1 0.063 12.1 0.1 1.2 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) PurS PF02700.14 PIK33220.1 - 0.087 13.0 0.3 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase TPR_19 PF14559.6 PIK33221.1 - 6.5e-07 29.8 0.0 0.086 13.4 0.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK33221.1 - 1.7e-05 24.4 1.9 0.044 13.6 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK33221.1 - 0.00026 20.6 0.2 1.7 8.4 0.0 4.6 5 0 0 5 5 5 1 TPR repeat TPR_14 PF13428.6 PIK33221.1 - 0.00048 20.7 1.0 21 6.2 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK33221.1 - 0.00049 20.1 5.3 1.3 9.4 0.1 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK33221.1 - 0.00064 19.9 0.9 11 6.7 0.0 4.5 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK33221.1 - 0.0011 18.9 11.3 0.41 10.9 0.3 5.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK33221.1 - 0.098 13.3 0.3 14 6.4 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Patched PF02460.18 PIK33223.1 - 2.7e-21 75.4 0.3 3.6e-21 75.0 0.3 1.2 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK33223.1 - 1.2e-18 67.4 5.6 2.2e-18 66.6 5.6 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Fz PF01392.22 PIK33224.1 - 0.00034 21.2 1.8 0.00034 21.2 1.8 2.3 2 0 0 2 2 2 1 Fz domain Folate_rec PF03024.14 PIK33224.1 - 0.007 16.3 0.8 0.015 15.2 0.1 1.8 2 0 0 2 2 2 1 Folate receptor family SPX PF03105.19 PIK33224.1 - 5 6.9 6.4 6.2 6.6 6.4 1.1 1 0 0 1 1 1 0 SPX domain Gal-3-0_sulfotr PF06990.11 PIK33225.1 - 1.8e-28 99.5 0.1 2.1e-28 99.3 0.1 1.3 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK33225.1 - 0.021 14.8 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK33226.1 - 3.6e-25 88.7 0.5 4.1e-25 88.5 0.5 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK33226.1 - 0.0017 18.3 0.3 0.003 17.5 0.1 1.5 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK33226.1 - 0.098 13.0 0.0 0.11 12.9 0.0 1.3 1 1 0 1 1 1 0 Sulfotransferase family RVT_1 PF00078.27 PIK33227.1 - 1.5e-29 103.1 0.0 2.9e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK33227.1 - 1.1e-20 73.5 0.1 2.1e-20 72.6 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK33227.1 - 2.7e-12 46.9 0.0 8.3e-12 45.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK33227.1 - 3e-05 24.3 0.0 6.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase NPP PF08384.10 PIK33227.1 - 0.0044 17.0 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region WD40 PF00400.32 PIK33229.1 - 1e-30 105.3 25.6 5.1e-07 30.3 0.2 8.0 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK33229.1 - 4e-08 33.4 4.3 0.009 16.3 0.0 5.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 PIK33229.1 - 4.7e-08 32.7 2.2 1e-07 31.7 2.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK33229.1 - 8.3e-07 28.8 2.2 2e-06 27.6 2.2 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 PIK33229.1 - 2.6e-06 26.4 10.2 0.38 9.4 0.1 5.0 3 1 2 5 5 5 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 PIK33229.1 - 0.0033 16.4 1.5 0.35 9.7 0.2 3.1 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF4508 PF14969.6 PIK33229.1 - 0.076 13.3 0.2 0.18 12.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) WD40_like PF17005.5 PIK33229.1 - 0.21 10.9 0.1 21 4.3 0.0 3.1 4 0 0 4 4 4 0 WD40-like domain UPRTase PF14681.6 PIK33230.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase IFT57 PF10498.9 PIK33232.1 - 0.017 14.1 1.9 0.03 13.3 1.9 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1351 PF07083.11 PIK33232.1 - 0.03 14.1 4.5 0.26 11.0 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) Fib_alpha PF08702.10 PIK33232.1 - 0.042 14.0 0.5 0.071 13.3 0.5 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Terminase_6C PF17289.2 PIK33232.1 - 0.078 13.1 0.4 0.42 10.7 0.1 2.2 2 0 0 2 2 2 0 Terminase RNaseH-like domain Prefoldin PF02996.17 PIK33232.1 - 0.13 12.2 2.2 0.22 11.5 1.4 1.8 1 1 0 1 1 1 0 Prefoldin subunit DUF2913 PF11140.8 PIK33232.1 - 0.17 11.6 3.3 1.2 8.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) MFS_1 PF07690.16 PIK33233.1 - 2.5e-06 26.7 1.7 2.9e-06 26.5 1.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK33233.1 - 0.00015 20.8 1.9 0.00017 20.6 1.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Gate PF07670.14 PIK33233.1 - 0.076 13.3 2.5 0.12 12.7 0.4 1.9 2 0 0 2 2 2 0 Nucleoside recognition DUF4806 PF16064.5 PIK33234.1 - 0.00011 22.4 0.1 0.0002 21.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4806) Creatininase PF02633.14 PIK33235.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Creatinine amidohydrolase PTS_IIA PF02255.16 PIK33237.1 - 0.095 12.8 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit RT_RNaseH PF17917.1 PIK33238.1 - 2.9e-25 88.6 0.4 5.8e-25 87.6 0.4 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33238.1 - 5.4e-13 49.0 0.1 1e-12 48.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK33238.1 - 9.4e-13 48.1 0.0 2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase BING4CT PF08149.11 PIK33238.1 - 0.04 13.7 0.2 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 BING4CT (NUC141) domain Integrase_H2C2 PF17921.1 PIK33239.1 - 2e-15 56.7 0.1 5.5e-15 55.2 0.1 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33239.1 - 8e-06 26.0 0.5 3.5e-05 23.9 0.1 2.2 2 0 0 2 2 2 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK33240.1 - 1.8e-33 114.5 0.0 2.9e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33240.1 - 6.2e-33 113.2 0.0 1.1e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Retrotrans_gag PF03732.17 PIK33241.1 - 3.6e-23 81.6 3.7 4.4e-22 78.2 0.9 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein RVT_1 PF00078.27 PIK33241.1 - 7e-21 74.8 0.0 1.4e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK33241.1 - 7.3e-06 25.8 1.8 1.4e-05 24.9 1.8 1.5 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK33241.1 - 0.00026 21.5 0.0 0.00048 20.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK33241.1 - 0.0012 19.5 0.0 0.0027 18.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_3 PF13917.6 PIK33241.1 - 0.054 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle BING4CT PF08149.11 PIK33241.1 - 0.11 12.3 0.1 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 BING4CT (NUC141) domain 4HBT_3 PF13622.6 PIK33242.1 - 0.00053 20.3 0.0 0.00059 20.2 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 PIK33242.1 - 0.0014 18.9 0.0 0.0023 18.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT PF03061.22 PIK33243.1 - 4e-11 43.1 0.2 5.9e-11 42.6 0.2 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 PIK33243.1 - 6.5e-06 26.6 0.0 8.9e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT_2 PF13279.6 PIK33243.1 - 0.085 13.3 0.0 0.15 12.6 0.0 1.5 1 1 0 1 1 1 0 Thioesterase-like superfamily PRELI PF04707.14 PIK33244.1 - 4.6e-28 98.0 0.1 1.9e-27 96.0 0.0 1.7 1 1 1 2 2 2 1 PRELI-like family Metallophos PF00149.28 PIK33245.1 - 0.00012 22.7 0.1 0.5 10.8 0.1 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK33245.1 - 0.006 16.8 0.1 2.8 8.1 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 PIK33245.1 - 0.015 14.6 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Dynein_C PF18199.1 PIK33246.1 - 1.1e-30 106.9 0.0 1.2e-30 106.8 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Kinesin PF00225.23 PIK33247.1 - 3.3e-21 75.6 0.2 3.3e-21 75.6 0.2 1.6 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK33248.1 - 4.4e-35 120.8 0.0 9.8e-35 119.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 PIK33248.1 - 1e-24 87.1 0.1 2.2e-24 86.0 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain DUF2730 PF10805.8 PIK33248.1 - 0.087 12.9 7.1 1.7 8.8 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Occludin_ELL PF07303.13 PIK33248.1 - 1.2 9.9 9.2 0.37 11.5 3.8 2.4 1 1 0 2 2 2 0 Occludin homology domain Sec2p PF06428.11 PIK33248.1 - 1.8 8.6 13.1 0.61 10.1 0.8 3.2 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p TMF_DNA_bd PF12329.8 PIK33248.1 - 5.3 7.1 18.1 0.3 11.1 5.8 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3972 PF13118.6 PIK33248.1 - 9.6 6.7 14.1 2.8 8.4 1.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3972) DNA_pol_A PF00476.20 PIK33249.1 - 4e-112 375.0 0.0 5.3e-112 374.6 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_P_Exo PF18049.1 PIK33249.1 - 0.0025 17.2 0.0 0.0066 15.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase nu pseudo-exo DUF4332 PF14229.6 PIK33250.1 - 0.018 15.3 0.1 0.071 13.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) HTH_31 PF13560.6 PIK33250.1 - 0.082 13.3 0.3 2.6 8.4 0.1 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain DEAD PF00270.29 PIK33251.1 - 8.3e-20 71.3 0.1 9.9e-19 67.8 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK33251.1 - 1.2e-06 28.7 0.0 6.1e-06 26.3 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 PIK33251.1 - 0.11 11.6 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 PIK33251.1 - 0.17 12.2 0.0 1.5 9.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain Pkinase_Tyr PF07714.17 PIK33252.1 - 7.2e-16 58.2 0.0 9.2e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC_membrane PF00664.23 PIK33253.1 - 1.7e-16 60.7 1.7 2e-16 60.4 1.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK33254.1 - 1.5e-23 83.8 0.4 1.1e-21 77.8 0.1 2.3 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 PIK33254.1 - 3.5e-10 40.0 2.7 3.5e-10 40.0 2.7 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 PIK33254.1 - 9.6e-05 22.4 1.2 0.0034 17.3 0.1 2.5 1 1 1 2 2 2 1 RsgA GTPase SMC_N PF02463.19 PIK33254.1 - 0.0012 18.3 0.3 1.1 8.7 0.1 2.6 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 PIK33254.1 - 0.0015 18.9 0.0 0.0028 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Dynamin_N PF00350.23 PIK33254.1 - 0.0034 17.5 0.6 0.0085 16.2 0.6 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK33254.1 - 0.0048 17.0 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.6 PIK33254.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain BSP_II PF05432.11 PIK33254.1 - 0.019 14.7 0.2 0.029 14.1 0.2 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Zeta_toxin PF06414.12 PIK33254.1 - 0.03 13.6 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 PIK33254.1 - 0.041 13.7 0.2 0.52 10.1 0.1 2.6 2 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 PIK33254.1 - 0.05 13.3 0.4 0.09 12.5 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK33254.1 - 0.074 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 PIK33254.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 PIK33254.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 PIK33254.1 - 0.18 12.1 0.1 0.48 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain G3P_acyltransf PF02660.15 PIK33255.1 - 0.021 14.9 1.9 0.047 13.8 1.9 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase RbsD_FucU PF05025.13 PIK33256.1 - 9.5e-18 64.9 0.1 9.7e-18 64.9 0.1 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family TetR_C_36 PF18598.1 PIK33256.1 - 0.11 12.5 0.1 0.14 12.1 0.1 1.4 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RT_RNaseH PF17917.1 PIK33257.1 - 0.011 16.0 0.2 0.1 12.9 0.2 2.2 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK33257.1 - 0.015 15.4 0.2 0.19 11.8 0.2 2.2 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33258.1 - 1.1e-29 103.6 0.0 1.4e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ADP_ribosyl_GH PF03747.14 PIK33259.1 - 1.6e-15 57.6 0.9 1.3e-14 54.6 0.3 2.2 1 1 1 2 2 2 2 ADP-ribosylglycohydrolase PAN_3 PF08277.12 PIK33260.1 - 0.034 14.0 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 PAN-like domain SBF2 PF12335.8 PIK33262.1 - 0.00083 19.0 1.8 0.0011 18.7 1.6 1.4 1 1 0 1 1 1 1 Myotubularin protein AAA_22 PF13401.6 PIK33264.1 - 0.0066 16.7 0.0 0.0086 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 PIK33264.1 - 0.02 15.4 0.2 0.022 15.3 0.2 1.4 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 PIK33264.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 PIK33264.1 - 0.031 13.8 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 PIK33264.1 - 0.041 13.6 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK33264.1 - 0.068 12.3 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RsgA_GTPase PF03193.16 PIK33264.1 - 0.14 12.1 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase wnt PF00110.19 PIK33265.1 - 8.8e-47 160.2 26.9 9.7e-47 160.0 26.9 1.0 1 0 0 1 1 1 1 wnt family Recep_L_domain PF01030.24 PIK33266.1 - 4.3e-15 55.8 0.0 5.7e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Receptor L domain Furin-like PF00757.20 PIK33266.1 - 3.1e-07 30.4 21.3 4.4e-07 29.9 21.3 1.3 1 0 0 1 1 1 1 Furin-like cysteine rich region TIL PF01826.17 PIK33266.1 - 7.6 6.9 28.5 3.4 8.0 17.5 2.3 1 1 1 2 2 2 0 Trypsin Inhibitor like cysteine rich domain FERM_C PF09380.10 PIK33267.1 - 3.5e-23 81.8 0.1 6.7e-23 80.9 0.1 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 PIK33267.1 - 1.4e-08 34.6 1.9 4.2e-08 33.2 1.9 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) RhoGEF PF00621.20 PIK33267.1 - 3.3e-07 30.7 0.3 7.5e-07 29.6 0.3 1.6 1 0 0 1 1 1 1 RhoGEF domain RhoGEF PF00621.20 PIK33268.1 - 4.4e-22 79.2 0.8 6.6e-22 78.6 0.8 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 PIK33268.1 - 0.0041 17.6 0.0 0.0072 16.8 0.0 1.4 1 0 0 1 1 1 1 PH domain DP PF08781.10 PIK33268.1 - 0.0046 16.8 2.1 0.5 10.3 0.4 2.4 2 0 0 2 2 2 2 Transcription factor DP IQ_SEC7_PH PF16453.5 PIK33268.1 - 0.011 15.7 0.1 0.029 14.3 0.0 1.9 2 0 0 2 2 2 0 PH domain H-kinase_dim PF02895.14 PIK33268.1 - 0.013 15.9 0.0 0.038 14.4 0.0 1.9 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Synaptobrevin PF00957.21 PIK33268.1 - 0.078 12.8 0.6 0.27 11.1 0.1 1.9 2 0 0 2 2 2 0 Synaptobrevin RNA_polI_A14 PF08203.11 PIK33268.1 - 0.14 12.9 0.0 0.45 11.3 0.0 1.8 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 DUF4298 PF14131.6 PIK33268.1 - 0.89 9.6 5.1 0.79 9.7 1.0 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4298) Exo_endo_phos_2 PF14529.6 PIK33269.1 - 2.5e-13 49.9 0.1 4.1e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HNOB PF07700.15 PIK33269.1 - 0.012 15.6 0.1 0.018 15.0 0.1 1.3 1 0 0 1 1 1 0 Haem-NO-binding TSC22 PF01166.18 PIK33269.1 - 0.026 14.9 2.8 1.6 9.1 0.4 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Exo_endo_phos PF03372.23 PIK33269.1 - 0.038 13.5 0.0 0.059 12.9 0.0 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family S-AdoMet_synt_N PF00438.20 PIK33269.1 - 0.074 13.7 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain SRP_TPR_like PF17004.5 PIK33270.1 - 2.7e-20 72.5 7.7 1.4e-17 63.8 0.3 3.3 2 1 1 3 3 3 2 Putative TPR-like repeat SRP72 PF08492.12 PIK33270.1 - 4.7e-16 59.0 7.0 4.7e-16 59.0 7.0 2.7 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_14 PF13428.6 PIK33270.1 - 1.1e-14 53.8 0.5 0.37 11.7 0.0 7.0 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK33270.1 - 3.8e-11 42.2 6.2 0.25 11.6 0.0 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK33270.1 - 2.3e-10 40.8 10.5 0.0076 16.7 0.0 7.1 3 2 2 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK33270.1 - 7.2e-10 39.0 3.8 0.00047 20.4 0.3 4.9 4 2 1 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK33270.1 - 2.2e-09 37.4 8.0 0.069 13.8 0.0 7.3 8 0 0 8 8 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK33270.1 - 1.5e-08 34.7 12.6 0.00037 20.7 0.3 6.1 2 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 PIK33270.1 - 1.1e-06 28.3 10.3 0.034 14.4 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK33270.1 - 1.1e-05 25.9 0.4 1.5 9.5 0.0 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK33270.1 - 2.2e-05 24.0 13.5 0.018 14.9 0.0 6.7 8 1 0 8 8 7 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK33270.1 - 2.5e-05 23.5 3.7 0.00048 19.2 0.7 3.2 1 1 2 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_21 PF09976.9 PIK33270.1 - 2.8e-05 23.9 7.5 0.0082 15.9 0.4 4.4 3 2 1 4 4 4 1 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 PIK33270.1 - 0.0016 18.1 0.1 2 8.2 0.0 3.7 3 0 0 3 3 3 1 TPR repeat DUF2989 PF11207.8 PIK33270.1 - 0.0064 16.3 9.1 0.94 9.2 0.1 3.7 3 1 0 3 3 3 2 Protein of unknown function (DUF2989) TPR_MalT PF17874.1 PIK33270.1 - 0.0067 15.8 0.1 0.19 11.1 0.0 2.3 2 1 1 3 3 3 1 MalT-like TPR region TPR_17 PF13431.6 PIK33270.1 - 0.017 15.5 2.7 7.3 7.2 0.1 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK33270.1 - 0.02 15.0 2.3 3.5 7.8 0.0 4.8 5 1 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK33270.1 - 0.023 14.6 0.6 38 4.3 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat rpo30_N PF12410.8 PIK33270.1 - 0.097 12.6 1.9 0.22 11.5 1.9 1.5 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit TPR_20 PF14561.6 PIK33270.1 - 0.24 11.8 5.1 14 6.1 0.0 4.2 4 2 1 5 5 5 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 PIK33271.1 - 3.4e-49 166.9 0.0 6.2e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK33271.1 - 3.1e-08 33.3 2.7 5.1e-08 32.6 2.7 1.3 1 0 0 1 1 1 1 Heme NO binding associated DICT PF10069.9 PIK33271.1 - 0.011 15.4 0.2 7.8 6.3 0.0 2.6 2 0 0 2 2 2 0 Sensory domain in DIguanylate Cyclases and Two-component system TnpV PF14198.6 PIK33271.1 - 0.081 12.9 1.3 2.2 8.3 0.0 2.4 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DUF1772 PF08592.11 PIK33271.1 - 0.2 12.0 0.0 0.37 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) 1-cysPrx_C PF10417.9 PIK33272.1 - 1.1e-09 37.9 0.2 1.7e-09 37.3 0.2 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin GCV_T PF01571.21 PIK33273.1 - 8e-65 218.7 0.0 1.3e-64 218.1 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 PIK33273.1 - 2e-42 146.1 0.0 3.4e-42 145.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK33273.1 - 0.00056 19.1 0.6 0.00091 18.4 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain SoxG PF04268.12 PIK33273.1 - 0.0016 18.6 0.0 0.0044 17.2 0.0 1.7 1 1 0 1 1 1 1 Sarcosine oxidase, gamma subunit family Pyr_redox_2 PF07992.14 PIK33273.1 - 0.0039 16.5 0.1 0.021 14.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK33273.1 - 0.013 15.7 0.6 0.037 14.2 0.6 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK33273.1 - 0.022 14.0 0.3 0.045 13.0 0.1 1.5 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 PIK33273.1 - 0.038 13.2 0.2 0.1 11.9 0.2 1.7 1 1 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 PIK33273.1 - 0.043 14.4 0.5 15 6.3 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAO_M PF16350.5 PIK33273.1 - 0.044 14.1 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain Pyr_redox_3 PF13738.6 PIK33273.1 - 0.17 11.1 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RVT_1 PF00078.27 PIK33274.1 - 4.1e-14 52.6 0.0 5.8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HrpF PF06266.12 PIK33274.1 - 0.077 13.3 0.2 0.23 11.8 0.1 1.9 2 0 0 2 2 2 0 HrpF protein RT_RNaseH PF17917.1 PIK33275.1 - 5.8e-28 97.2 0.0 8.7e-28 96.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK33275.1 - 6.5e-26 90.3 0.0 1.2e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK33275.1 - 3.6e-13 49.4 0.0 6.7e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33275.1 - 0.063 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger Cellulase-like PF12876.7 PIK33276.1 - 0.007 15.8 0.1 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Sugar-binding cellulase-like fn3 PF00041.21 PIK33277.1 - 1.1e-07 32.0 1.1 0.00011 22.4 0.5 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Lectin_C PF00059.21 PIK33277.1 - 2.2e-07 31.6 0.1 0.026 15.3 0.0 2.5 2 0 0 2 2 2 2 Lectin C-type domain HAP2-GCS1 PF10699.9 PIK33277.1 - 0.064 13.2 4.7 0.93 9.5 0.1 3.4 4 0 0 4 4 4 0 Male gamete fusion factor CUB PF00431.20 PIK33278.1 - 1.1e-61 206.0 0.0 1.4e-13 51.1 0.0 5.4 5 0 0 5 5 5 5 CUB domain Lectin_C PF00059.21 PIK33278.1 - 9.2e-57 190.4 9.9 7.7e-14 52.3 0.1 4.6 4 0 0 4 4 4 4 Lectin C-type domain fn3 PF00041.21 PIK33278.1 - 1.5e-28 98.9 3.6 2.9e-08 34.0 0.0 5.5 5 0 0 5 5 5 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK33278.1 - 0.0013 19.3 2.3 28 5.4 0.0 4.7 4 0 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain Chordopox_A33R PF05966.12 PIK33278.1 - 0.005 16.1 0.1 3.9 6.7 0.0 3.3 3 0 0 3 3 3 1 Chordopoxvirus A33R protein DUF3558 PF12079.8 PIK33278.1 - 0.0066 16.5 0.1 0.89 9.5 0.2 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3558) CUB_2 PF02408.20 PIK33278.1 - 0.29 10.9 8.5 4.6 7.0 0.0 5.2 5 1 1 6 6 6 0 CUB-like domain CUB PF00431.20 PIK33279.1 - 6.1e-18 65.2 0.0 1.8e-17 63.7 0.0 1.9 1 0 0 1 1 1 1 CUB domain Lectin_C PF00059.21 PIK33279.1 - 2.4e-11 44.3 0.3 1e-10 42.3 0.3 2.2 1 1 0 1 1 1 1 Lectin C-type domain fn3 PF00041.21 PIK33279.1 - 1.7e-09 37.9 1.3 1.5e-08 34.8 0.3 2.8 2 0 0 2 2 2 1 Fibronectin type III domain MAP17 PF15807.5 PIK33279.1 - 0.0016 18.7 0.0 0.0032 17.7 0.0 1.5 1 1 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FokI_N PF02981.15 PIK33280.1 - 0.096 12.9 0.6 0.21 11.7 0.6 1.6 1 1 0 1 1 1 0 Restriction endonuclease FokI, recognition domain CXCXC PF03128.14 PIK33281.1 - 0.00054 20.2 0.9 0.013 15.9 0.0 12.4 12 0 0 12 12 12 8 CXCXC repeat 7tm_1 PF00001.21 PIK33282.1 - 2.3e-18 66.5 7.4 3.1e-18 66.1 7.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK33282.1 - 0.00014 21.3 8.2 0.00018 21.0 8.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peptidase_A22B PF04258.13 PIK33282.1 - 0.012 15.2 6.3 0.014 14.9 6.3 1.1 1 0 0 1 1 1 0 Signal peptide peptidase 7tm_1 PF00001.21 PIK33283.1 - 6.9e-19 68.2 3.4 8e-19 68.0 3.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Gaa1 PF04114.14 PIK33283.1 - 0.016 14.2 1.5 0.023 13.7 1.5 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component Tub PF01167.18 PIK33284.1 - 3.8e-29 102.1 0.7 4.6e-29 101.9 0.7 1.2 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.8 PIK33284.1 - 0.0084 15.7 0.1 0.0084 15.7 0.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3527) RR_TM4-6 PF06459.12 PIK33284.1 - 3.8 7.3 8.4 4.8 6.9 8.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoU_sub_bind PF08032.12 PIK33285.1 - 3.8e-15 55.9 0.0 8.5e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding SpoU_methylase PF00588.19 PIK33285.1 - 5.9e-10 39.5 0.0 1.5e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 SpoU rRNA Methylase family Pex14_N PF04695.13 PIK33285.1 - 2.8 8.6 10.0 1.9 9.2 0.2 2.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4430 PF14478.6 PIK33286.1 - 0.0038 17.8 1.2 0.01 16.4 1.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4430) Cobalamin_bind PF01122.19 PIK33287.1 - 5.7e-17 61.6 0.0 2.2e-12 46.6 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic cobalamin-binding protein PCMT PF01135.19 PIK33289.1 - 3.8e-71 239.2 1.1 1.3e-70 237.4 1.1 1.7 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 PIK33289.1 - 1.4e-10 41.2 0.0 2.4e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK33289.1 - 2.6e-09 37.7 0.0 5.7e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK33289.1 - 6.5e-07 29.9 0.0 1.8e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK33289.1 - 1.1e-06 28.2 0.0 1.8e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK33289.1 - 2.6e-06 27.4 0.0 4.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK33289.1 - 2.9e-06 26.8 0.0 4.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 PIK33289.1 - 1e-05 25.6 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK33289.1 - 8.3e-05 22.2 0.0 0.00016 21.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 PIK33289.1 - 0.00053 19.9 0.0 0.0012 18.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 PIK33289.1 - 0.001 18.9 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_24 PF13578.6 PIK33289.1 - 0.0019 19.2 0.0 0.0047 17.9 0.0 1.7 1 1 1 2 2 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 PIK33289.1 - 0.0025 17.0 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase GCD14 PF08704.10 PIK33289.1 - 0.0032 17.2 0.1 0.0061 16.3 0.1 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Fibrillarin PF01269.17 PIK33289.1 - 0.0037 16.4 0.0 0.0083 15.3 0.0 1.5 1 0 0 1 1 1 1 Fibrillarin Methyltransf_16 PF10294.9 PIK33289.1 - 0.0085 15.8 0.1 0.014 15.2 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 PIK33289.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 PIK33289.1 - 0.012 15.2 0.0 0.028 14.1 0.0 1.5 1 1 1 2 2 2 0 16S rRNA methyltransferase RsmB/F Methyltransf_9 PF08003.11 PIK33289.1 - 0.013 14.4 0.0 0.03 13.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) AviRa PF11599.8 PIK33289.1 - 0.026 14.0 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_12 PF08242.12 PIK33289.1 - 0.093 13.5 0.0 0.3 11.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 PIK33289.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 PIK33289.1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MetW PF07021.12 PIK33289.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Nitroreductase PF00881.24 PIK33290.1 - 3.4e-06 27.2 0.0 4.1e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Syntaxin PF00804.25 PIK33291.1 - 0.094 12.4 8.1 0.11 12.1 8.1 1.1 1 0 0 1 1 1 0 Syntaxin Allexi_40kDa PF05549.11 PIK33291.1 - 0.56 9.7 3.4 0.6 9.6 3.4 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein TMPIT PF07851.13 PIK33291.1 - 2.6 7.2 7.3 2.8 7.1 7.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein PIGA PF08288.12 PIK33292.1 - 2.5e-43 146.6 0.7 6.1e-43 145.3 0.7 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 PIK33292.1 - 2.6e-27 95.9 0.0 4.3e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 PIK33292.1 - 2.7e-26 92.2 0.0 4.4e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK33292.1 - 1.1e-21 77.7 0.0 2.2e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 PIK33292.1 - 6.6e-09 36.4 0.0 1e-08 35.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 PIK33292.1 - 0.0024 17.9 0.1 0.0045 17.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_5 PF08323.11 PIK33292.1 - 0.016 14.9 0.3 0.12 12.1 0.0 2.1 1 1 0 2 2 2 0 Starch synthase catalytic domain Glyco_trans_1_2 PF13524.6 PIK33292.1 - 0.021 15.2 0.0 0.058 13.8 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferases group 1 Pep_M12B_propep PF01562.19 PIK33293.1 - 6.2e-14 52.4 0.0 8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Reprolysin family propeptide zf_C2H2_6 PF18450.1 PIK33293.1 - 0.096 12.4 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Zinc Finger domain TSP_1 PF00090.19 PIK33294.1 - 3e-08 33.7 5.4 3e-08 33.7 5.4 2.3 3 0 0 3 3 3 1 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 PIK33294.1 - 3e-06 27.7 1.3 3e-06 27.7 1.3 2.8 4 0 0 4 4 4 1 ADAM cysteine-rich domain ADAM_spacer1 PF05986.14 PIK33295.1 - 9.9e-11 41.7 0.0 1.4e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 PIK33295.1 - 0.0091 16.2 25.3 0.012 15.8 5.6 3.1 3 1 0 3 3 3 2 Thrombospondin type 1 domain MFS_1 PF07690.16 PIK33296.1 - 2.5e-06 26.7 0.4 3e-06 26.4 0.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK33296.1 - 0.00024 20.1 1.3 0.00036 19.5 1.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1440 PF07274.12 PIK33296.1 - 0.028 14.8 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) NEMP PF10225.9 PIK33296.1 - 0.03 14.0 1.2 0.044 13.4 1.2 1.2 1 0 0 1 1 1 0 NEMP family CABIT PF12736.7 PIK33297.1 - 7.2e-05 22.2 0.8 0.0018 17.6 0.8 2.5 1 1 0 1 1 1 1 Cell-cycle sustaining, positive selection, Lectin_N PF03954.14 PIK33298.1 - 2.5 7.8 10.6 2.1 8.1 3.6 2.8 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain CREPT PF16566.5 PIK33298.1 - 9.9 6.3 11.1 11 6.2 5.6 2.5 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Kinesin PF00225.23 PIK33299.1 - 9.4e-80 268.0 0.2 3.9e-79 266.0 0.1 1.7 1 1 1 2 2 2 1 Kinesin motor domain DUF3169 PF11368.8 PIK33299.1 - 0.025 14.1 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Microtub_bd PF16796.5 PIK33299.1 - 0.06 13.3 0.4 0.71 9.8 0.1 2.3 1 1 1 2 2 2 0 Microtubule binding Glyco_transf_7C PF02709.14 PIK33301.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase RVT_1 PF00078.27 PIK33302.1 - 2.8e-07 30.3 1.9 4.6e-07 29.6 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) NAGidase PF07555.13 PIK33302.1 - 0.0066 15.8 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Fibrinogen_C PF00147.18 PIK33303.1 - 9.2e-26 91.0 2.6 1e-25 90.9 2.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ig_3 PF13927.6 PIK33304.1 - 4e-09 37.0 0.5 0.0011 19.6 0.0 4.2 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK33304.1 - 1.9e-05 24.6 0.2 0.017 15.2 0.0 3.3 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK33304.1 - 0.0036 17.4 0.9 0.04 14.1 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK33304.1 - 0.026 14.6 0.4 1.7 8.8 0.1 3.4 2 2 0 2 2 2 0 Immunoglobulin I-set domain zf-RING_2 PF13639.6 PIK33305.1 - 9.3e-12 45.1 5.7 1.6e-11 44.4 5.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 PIK33305.1 - 4.1e-08 33.4 7.6 2.5e-07 30.9 7.6 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 PIK33305.1 - 4.7e-08 32.7 5.9 8e-08 32.0 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK33305.1 - 1.7e-07 31.0 5.3 2.9e-07 30.3 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK33305.1 - 7.7e-07 29.0 1.5 1.7e-06 28.0 1.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 PIK33305.1 - 2.9e-06 26.9 4.6 5.9e-06 25.9 4.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 PIK33305.1 - 4.1e-05 23.3 3.2 6.4e-05 22.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 PIK33305.1 - 9.4e-05 22.4 4.1 0.0004 20.4 4.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 PIK33305.1 - 0.00021 21.2 4.3 0.00038 20.4 4.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 PIK33305.1 - 0.00081 19.0 4.7 0.0015 18.1 4.7 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 PIK33305.1 - 0.009 15.8 3.9 0.023 14.5 3.6 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zinc_ribbon_16 PF17034.5 PIK33305.1 - 0.057 13.6 0.7 0.11 12.7 0.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family DUF1759 PF03564.15 PIK33305.1 - 0.061 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) zf-C3HC4_4 PF15227.6 PIK33305.1 - 0.064 13.4 3.9 0.14 12.3 3.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 PIK33305.1 - 0.068 13.4 6.2 0.38 11.0 6.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 PIK33305.1 - 0.1 12.9 5.4 0.22 11.9 5.4 1.6 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.6 PIK33305.1 - 0.12 12.2 3.9 0.27 11.1 3.8 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 PIK33305.1 - 0.28 11.3 6.8 0.8 9.9 6.8 1.8 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 PIK33305.1 - 0.96 9.5 4.6 1.9 8.6 4.6 1.5 1 0 0 1 1 1 0 Zinc-finger Glyco_hydro_25 PF01183.20 PIK33306.1 - 0.054 13.7 0.2 0.054 13.7 0.2 1.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 25 DUF3772 PF12607.8 PIK33306.1 - 0.15 11.9 0.4 0.15 11.9 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3772) DAPDH_C PF16654.5 PIK33306.1 - 0.19 11.6 3.1 0.2 11.5 0.6 2.1 1 1 2 3 3 3 0 Diaminopimelic acid dehydrogenase C-terminal domain Fib_alpha PF08702.10 PIK33306.1 - 0.7 10.1 33.2 0.093 12.9 8.0 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Filament PF00038.21 PIK33306.1 - 5.8 6.4 34.6 0.34 10.4 8.4 2.9 1 1 1 2 2 2 0 Intermediate filament protein TPR_1 PF00515.28 PIK33307.1 - 6.2e-06 25.8 4.0 0.048 13.5 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK33307.1 - 0.025 14.7 8.1 0.87 9.9 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK33307.1 - 0.16 12.4 3.7 8 7.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK33307.1 - 0.39 10.4 5.1 0.16 11.6 0.2 2.8 3 0 0 3 3 3 0 TPR repeat Phosphodiest PF01663.22 PIK33308.1 - 4.5e-25 89.0 0.2 5.3e-25 88.8 0.2 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase OTCace PF00185.24 PIK33309.1 - 6.8e-34 117.2 0.1 1.3e-33 116.2 0.0 1.5 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 PIK33309.1 - 1.4e-25 90.0 0.0 3e-25 89.0 0.0 1.5 1 1 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Asparaginase_C PF17763.1 PIK33309.1 - 0.075 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Amidohydro_1 PF01979.20 PIK33311.1 - 5.2e-11 42.5 0.6 9e-10 38.4 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family MGS PF02142.22 PIK33312.1 - 1.7e-13 50.6 0.0 3.1e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain CPSase_L_D2 PF02786.17 PIK33313.1 - 6.3e-97 323.2 0.1 2e-83 279.0 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 PIK33313.1 - 3.6e-42 143.6 0.1 7.8e-42 142.5 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 PIK33313.1 - 8.9e-16 58.0 0.7 4.6e-07 29.6 0.1 2.6 2 1 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 PIK33313.1 - 1.3e-12 47.6 0.1 1.4e-05 24.8 0.1 2.3 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 PIK33313.1 - 1.5e-06 28.0 0.2 0.00015 21.5 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 PIK33313.1 - 0.0023 18.0 0.1 0.43 10.6 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain PDDEXK_10 PF07788.11 PIK33313.1 - 0.21 11.5 1.0 0.75 9.8 0.5 2.1 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily GATase PF00117.28 PIK33314.1 - 4.2e-06 26.6 0.1 0.00034 20.4 0.0 2.4 2 1 0 2 2 2 2 Glutamine amidotransferase class-I ALS2CR8 PF15299.6 PIK33315.1 - 1.7e-05 24.9 1.7 4.2e-05 23.5 1.2 1.7 1 1 1 2 2 2 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 WD40 PF00400.32 PIK33316.1 - 3.3e-32 110.0 19.6 1.4e-05 25.7 0.0 10.6 10 0 0 10 10 10 5 WD domain, G-beta repeat EF-hand_7 PF13499.6 PIK33316.1 - 4.5e-08 33.4 1.3 4.5e-08 33.4 1.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair ANAPC4_WD40 PF12894.7 PIK33316.1 - 7.4e-08 32.6 0.3 8.7e-05 22.8 0.0 5.8 7 2 1 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_8 PF13833.6 PIK33316.1 - 1.1e-07 31.6 1.6 3.2e-07 30.1 1.6 1.8 1 0 0 1 1 1 1 EF-hand domain pair Nup160 PF11715.8 PIK33316.1 - 1.3e-05 24.1 0.5 0.033 12.9 0.1 3.4 1 1 2 4 4 4 2 Nucleoporin Nup120/160 EF-hand_6 PF13405.6 PIK33316.1 - 2.6e-05 23.8 0.3 0.44 10.6 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain Nucleoporin_N PF08801.11 PIK33316.1 - 0.00014 20.8 0.1 1 8.1 0.0 3.7 3 0 0 3 3 3 2 Nup133 N terminal like EF-hand_1 PF00036.32 PIK33316.1 - 0.00051 19.4 0.4 0.037 13.6 0.1 3.1 2 0 0 2 2 2 1 EF hand CDtoxinA PF03498.14 PIK33316.1 - 0.0037 16.8 0.1 1.3 8.6 0.0 2.6 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain Hira PF07569.11 PIK33316.1 - 0.0053 16.5 0.6 8.5 6.0 0.0 3.8 4 0 0 4 4 4 1 TUP1-like enhancer of split BBS2_Mid PF14783.6 PIK33316.1 - 0.022 14.8 1.0 64 3.6 0.0 5.8 7 1 0 7 7 7 0 Ciliary BBSome complex subunit 2, middle region PsbN PF02468.15 PIK33317.1 - 0.16 11.9 0.5 0.25 11.2 0.5 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) PseudoU_synth_1 PF01416.20 PIK33318.1 - 1e-28 100.0 0.0 2.7e-21 76.0 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase REPA_OB_2 PF16900.5 PIK33320.1 - 0.0026 17.7 0.1 0.0039 17.1 0.1 1.3 1 0 0 1 1 1 1 Replication protein A OB domain DUF3127 PF11325.8 PIK33320.1 - 0.016 15.5 0.1 0.029 14.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) Rep_fac-A_C PF08646.10 PIK33322.1 - 2.9e-07 30.3 9.4 1.2e-05 25.1 6.5 2.5 2 1 0 2 2 2 2 Replication factor-A C terminal domain CDC24_OB3 PF17244.2 PIK33322.1 - 0.00058 19.6 8.9 0.0033 17.2 8.9 1.9 1 1 0 1 1 1 1 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 PIK33322.1 - 0.0015 18.5 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 PIK33322.1 - 0.0046 16.8 1.1 0.009 15.9 1.1 1.5 1 0 0 1 1 1 1 Replication protein A OB domain zf-ribbon_3 PF13248.6 PIK33322.1 - 0.0055 16.1 1.0 0.0055 16.1 1.0 2.8 3 0 0 3 3 3 1 zinc-ribbon domain LRR_8 PF13855.6 PIK33323.1 - 4.8e-16 58.3 12.2 5e-11 42.2 4.5 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK33323.1 - 5.7e-09 36.1 10.6 1.5e-06 28.4 3.7 3.6 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK33323.1 - 7.8e-05 22.7 13.9 0.14 12.8 0.0 5.6 6 2 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK33323.1 - 0.023 14.2 5.8 0.064 12.8 5.8 1.6 1 1 0 1 1 1 0 Leucine-rich repeat LRR_5 PF13306.6 PIK33323.1 - 0.027 14.4 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK33323.1 - 0.47 10.6 10.7 0.93 9.7 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 PIK33324.1 - 1.3e-15 56.9 12.4 7.4e-11 41.7 4.5 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK33324.1 - 6.1e-09 36.0 21.5 2.5e-06 27.7 3.9 3.5 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK33324.1 - 0.00033 20.8 13.1 0.2 12.3 0.0 5.0 4 1 0 4 4 4 2 Leucine Rich Repeat LRRNT PF01462.18 PIK33324.1 - 0.024 14.3 0.8 0.066 12.9 0.8 1.8 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 PIK33324.1 - 0.03 13.8 5.4 0.12 11.9 4.9 1.6 1 1 0 1 1 1 0 Leucine-rich repeat LRR_5 PF13306.6 PIK33324.1 - 0.032 14.2 0.2 0.08 12.9 0.2 1.6 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK33324.1 - 1.1 9.5 10.7 1.3 9.3 0.1 4.0 4 0 0 4 4 4 0 Leucine Rich repeat PMP22_Claudin PF00822.20 PIK33325.1 - 3.8e-07 30.1 12.6 2.4e-05 24.3 12.6 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 PIK33325.1 - 4.6e-07 29.8 3.5 6.4e-07 29.3 3.5 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Baculo_LEF-11 PF06385.12 PIK33325.1 - 0.03 14.8 1.8 0.088 13.3 0.1 2.2 2 0 0 2 2 2 0 Baculovirus LEF-11 protein Pex24p PF06398.11 PIK33325.1 - 3.3 6.6 11.7 76 2.1 11.7 2.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin TIMP PF00965.17 PIK33326.1 - 4.3e-11 42.9 0.6 4.8e-11 42.8 0.6 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK33326.1 - 0.01 15.7 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 0 UNC-6/NTR/C345C module RVT_1 PF00078.27 PIK33328.1 - 3e-05 23.6 0.0 4.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lectin_C PF00059.21 PIK33329.1 - 6.3e-30 104.1 4.5 1.4e-22 80.4 0.5 2.1 2 0 0 2 2 2 2 Lectin C-type domain Syndecan PF01034.20 PIK33329.1 - 0.003 17.4 1.5 0.0056 16.6 1.5 1.4 1 0 0 1 1 1 1 Syndecan domain UL45 PF05473.12 PIK33329.1 - 0.0065 16.1 0.1 0.0065 16.1 0.1 3.1 2 1 1 3 3 3 1 UL45 protein, carbohydrate-binding C-type lectin-like Amnionless PF14828.6 PIK33329.1 - 0.14 10.9 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Amnionless Glyoxalase_4 PF13669.6 PIK33333.1 - 0.082 13.2 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fibrinogen_C PF00147.18 PIK33334.1 - 2.1e-25 89.9 1.1 2.4e-25 89.7 1.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Mpv17_PMP22 PF04117.12 PIK33335.1 - 5.4e-12 45.8 6.0 1.1e-11 44.7 5.9 1.7 1 1 0 1 1 1 1 Mpv17 / PMP22 family DUF4059 PF13268.6 PIK33335.1 - 0.039 14.3 0.4 0.14 12.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) Acetyltransf_1 PF00583.25 PIK33337.1 - 0.0011 19.2 0.0 0.0024 18.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK33337.1 - 0.0086 16.5 0.0 0.33 11.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 PIK33337.1 - 0.035 14.0 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK33337.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein NAGidase PF07555.13 PIK33339.1 - 6.7e-16 58.5 0.0 1.2e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase NAGidase PF07555.13 PIK33340.1 - 2.8e-17 63.0 0.0 3e-17 62.9 0.0 1.0 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase RVT_1 PF00078.27 PIK33341.1 - 1e-19 71.0 0.0 1.3e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DER1 PF04511.15 PIK33342.1 - 2.2e-72 243.0 14.4 2.6e-72 242.8 14.4 1.0 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.17 PIK33342.1 - 0.0031 17.2 0.8 0.0066 16.2 0.0 1.8 1 1 1 2 2 2 1 Oleosin Rhomboid PF01694.22 PIK33342.1 - 0.64 10.0 13.4 1 9.4 13.4 1.3 1 0 0 1 1 1 0 Rhomboid family TFA2_Winged_2 PF18121.1 PIK33343.1 - 0.0046 16.6 0.8 0.47 10.2 0.1 2.3 2 0 0 2 2 2 2 TFA2 Winged helix domain 2 zf-FPG_IleRS PF06827.14 PIK33343.1 - 0.043 13.7 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS zf-C2H2_4 PF13894.6 PIK33344.1 - 2.4e-07 31.0 10.4 0.015 16.1 0.8 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK33344.1 - 3e-07 30.5 14.9 0.0029 18.0 1.8 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 PIK33344.1 - 0.002 18.8 5.9 0.43 11.3 5.9 3.0 1 1 0 1 1 1 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 PIK33344.1 - 0.0051 17.1 6.3 0.45 10.9 0.3 3.0 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 PIK33344.1 - 0.0071 16.4 6.0 2.5 8.3 0.2 3.3 3 0 0 3 3 3 2 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 PIK33344.1 - 0.008 16.1 2.3 0.008 16.1 2.3 2.0 2 0 0 2 2 2 1 SprT-like zinc ribbon domain zf-H2C2_2 PF13465.6 PIK33344.1 - 0.061 13.8 1.6 0.061 13.8 1.6 4.1 5 1 0 5 5 4 0 Zinc-finger double domain EGF_CA PF07645.15 PIK33344.1 - 0.12 12.7 0.7 8.2 6.7 0.1 2.5 2 0 0 2 2 2 0 Calcium-binding EGF domain zf-C2H2_6 PF13912.6 PIK33344.1 - 0.12 12.4 0.9 0.12 12.4 0.9 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Desulfoferrod_N PF06397.12 PIK33344.1 - 0.21 11.2 4.0 8.7 6.1 0.9 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zinc_ribbon_5 PF13719.6 PIK33344.1 - 0.27 11.0 7.0 4.9 7.0 0.1 3.8 3 1 0 3 3 3 0 zinc-ribbon domain C1_4 PF07975.12 PIK33344.1 - 0.41 10.9 7.8 2.1 8.6 1.7 3.1 1 1 2 3 3 3 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 PIK33344.1 - 0.84 10.0 5.4 6.9 7.1 0.5 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK33344.1 - 4 7.8 7.5 0.28 11.5 1.7 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CCHC_2 PF13696.6 PIK33344.1 - 6.6 6.7 7.3 4.5 7.2 2.0 2.4 2 0 0 2 2 2 0 Zinc knuckle Lipase PF00151.19 PIK33345.1 - 5.3e-35 121.3 0.5 6.5e-35 121.0 0.5 1.0 1 0 0 1 1 1 1 Lipase zf-C2HC_2 PF13913.6 PIK33346.1 - 2.9e-11 43.0 8.5 1.6e-06 27.8 1.4 2.8 2 0 0 2 2 2 2 zinc-finger of a C2HC-type DZR PF12773.7 PIK33346.1 - 0.0046 17.0 1.2 0.0046 17.0 1.2 3.1 2 1 0 2 2 2 1 Double zinc ribbon YacG PF03884.14 PIK33346.1 - 0.031 14.0 1.8 0.031 14.0 1.8 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Rad50_zn_hook PF04423.14 PIK33346.1 - 0.43 10.4 4.4 7.6 6.5 1.1 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif HypA PF01155.19 PIK33346.1 - 6.5 6.8 5.7 20 5.3 0.1 2.7 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.10 PIK33346.1 - 7.9 7.2 9.2 42 4.9 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (FYDLN_acid) Nop14 PF04147.12 PIK33347.1 - 0.0022 16.3 5.7 0.0023 16.2 5.7 1.1 1 0 0 1 1 1 1 Nop14-like family YL1 PF05764.13 PIK33347.1 - 0.0027 17.9 7.2 0.0035 17.5 7.2 1.3 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.12 PIK33347.1 - 0.051 13.0 10.9 0.066 12.6 10.9 1.2 1 0 0 1 1 1 0 SDA1 DUF5643 PF18705.1 PIK33347.1 - 0.076 13.0 0.0 0.076 13.0 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5643) CDC45 PF02724.14 PIK33347.1 - 0.18 10.0 10.4 0.23 9.7 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 PIK33347.1 - 0.6 8.6 10.7 0.88 8.0 10.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Merozoite_SPAM PF07133.11 PIK33347.1 - 1.8 8.6 25.1 3.2 7.7 25.1 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) GEN1_C PF18380.1 PIK33347.1 - 7.9 7.4 13.7 9.7 7.1 0.1 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Y_phosphatase PF00102.27 PIK33348.1 - 1.6e-47 162.1 2.6 1.7e-42 145.6 1.2 2.6 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK33348.1 - 3.6e-10 40.0 2.1 2.1e-06 28.0 0.1 3.1 3 0 0 3 3 3 2 Fibronectin type III domain DSPc PF00782.20 PIK33348.1 - 2.1e-05 24.4 0.0 5.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK33348.1 - 0.082 13.0 0.2 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Syndecan PF01034.20 PIK33348.1 - 0.24 11.3 0.9 0.6 10.1 0.9 1.6 1 0 0 1 1 1 0 Syndecan domain Kinesin PF00225.23 PIK33349.1 - 1.5e-58 198.3 0.0 1.5e-58 198.3 0.0 2.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK33349.1 - 4.1e-47 159.8 0.0 4.1e-47 159.8 0.0 2.7 3 1 0 3 3 3 1 Microtubule binding LMBR1 PF04791.16 PIK33349.1 - 2.8e-06 26.6 28.4 0.00067 18.7 3.4 2.1 2 0 0 2 2 2 2 LMBR1-like membrane protein Filament PF00038.21 PIK33349.1 - 0.086 12.4 66.0 1.1 8.8 31.7 3.3 1 1 1 3 3 3 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 PIK33349.1 - 0.12 12.4 75.9 0.62 10.1 32.0 4.8 2 1 3 5 5 5 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 PIK33349.1 - 5.6 7.0 15.5 4 7.5 3.9 3.7 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 PIK33349.1 - 8.8 5.6 42.8 22 4.2 21.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) MAD PF05557.13 PIK33350.1 - 0.00055 18.4 25.9 0.02 13.3 11.1 2.1 1 1 1 2 2 2 2 Mitotic checkpoint protein DUF2353 PF09789.9 PIK33350.1 - 0.0013 18.2 19.7 0.021 14.2 19.7 2.1 1 1 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Golgin_A5 PF09787.9 PIK33350.1 - 1.1 8.7 28.4 0.37 10.2 5.9 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 Fib_alpha PF08702.10 PIK33350.1 - 1.7 8.8 22.3 3.1 8.0 8.8 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 PIK33350.1 - 2.5 7.4 12.3 1.4 8.2 6.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Phosphodiest PF01663.22 PIK33351.1 - 5.9e-43 147.8 0.1 7.3e-43 147.5 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 PIK33351.1 - 5.4e-05 22.7 0.0 8.8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 PIK33351.1 - 0.0025 17.3 0.0 0.016 14.6 0.0 2.0 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 PIK33351.1 - 0.013 14.1 0.0 0.016 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Rax2 PF12768.7 PIK33351.1 - 0.024 14.1 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1501 PF07394.12 PIK33351.1 - 0.11 11.5 0.0 0.46 9.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) TraT PF05818.12 PIK33356.1 - 0.095 12.4 0.2 0.17 11.5 0.2 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein BAT PF15915.5 PIK33358.1 - 0.023 14.6 0.1 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 GAF and HTH_10 associated domain Ribosomal_L11_N PF03946.14 PIK33362.1 - 6.8e-13 48.3 0.1 1e-12 47.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 PIK33362.1 - 4.4e-12 46.3 0.1 5.2e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Mob1_phocein PF03637.17 PIK33363.1 - 7.5e-75 250.6 0.4 9.7e-75 250.2 0.4 1.1 1 0 0 1 1 1 1 Mob1/phocein family G-gamma PF00631.22 PIK33363.1 - 0.061 13.3 0.1 11 6.2 0.0 2.5 2 0 0 2 2 2 0 GGL domain Prominin PF05478.11 PIK33364.1 - 5.9e-22 77.5 0.0 7.8e-22 77.1 0.0 1.0 1 0 0 1 1 1 1 Prominin TMEM169 PF15052.6 PIK33364.1 - 0.063 13.4 1.4 0.087 12.9 1.4 1.2 1 0 0 1 1 1 0 TMEM169 protein family Prominin PF05478.11 PIK33365.1 - 2.2e-18 65.7 1.1 2.8e-18 65.3 1.1 1.1 1 0 0 1 1 1 1 Prominin DUF2099 PF09872.9 PIK33365.1 - 1.9e-05 24.0 2.7 4 6.6 0.0 4.8 1 1 4 5 5 5 4 Uncharacterized protein conserved in archaea (DUF2099) RPN6_C_helix PF18503.1 PIK33365.1 - 0.02 14.6 4.3 1.5e+02 2.2 0.0 5.3 5 0 0 5 5 5 0 26S proteasome subunit RPN6 C-terminal helix domain Ig_3 PF13927.6 PIK33366.1 - 3.5e-40 136.5 4.5 3e-11 43.8 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 PIK33366.1 - 7.4e-38 128.5 4.5 4.3e-09 36.3 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.25 PIK33366.1 - 2e-31 108.0 1.6 6.9e-07 29.3 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK33366.1 - 3.2e-28 97.9 2.0 2.4e-06 27.8 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK33366.1 - 6.9e-28 97.0 1.5 1.7e-07 31.4 0.0 5.2 4 1 0 4 4 4 3 Immunoglobulin V-set domain Shisa PF13908.6 PIK33366.1 - 0.0019 18.5 1.9 0.011 16.0 0.1 2.6 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator OppC_N PF12911.7 PIK33366.1 - 0.014 15.4 1.3 0.027 14.4 1.3 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF2207 PF09972.9 PIK33366.1 - 0.033 13.0 0.0 0.16 10.7 0.0 2.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Peptidase_M56 PF05569.11 PIK33366.1 - 0.042 13.0 0.2 0.071 12.3 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF3139 PF11337.8 PIK33366.1 - 0.12 13.0 0.6 0.3 11.8 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF4834 PF16118.5 PIK33366.1 - 0.32 12.0 9.0 2.4 9.1 2.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) ETRAMP PF09716.10 PIK33366.1 - 0.49 10.5 2.2 0.75 9.9 0.3 2.3 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) TMEM154 PF15102.6 PIK33366.1 - 0.53 10.2 2.9 0.4 10.6 0.3 2.1 2 0 0 2 2 2 0 TMEM154 protein family Orf78 PF06024.12 PIK33366.1 - 3.9 7.8 5.2 0.75 10.1 0.9 2.0 2 0 0 2 2 1 0 Orf78 (ac78) RPAP1_C PF08620.10 PIK33367.1 - 5.2e-11 42.5 0.3 1.1e-10 41.4 0.3 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal Cupin_5 PF06172.11 PIK33368.1 - 0.05 13.8 0.5 0.071 13.3 0.5 1.2 1 0 0 1 1 1 0 Cupin superfamily (DUF985) rve PF00665.26 PIK33372.1 - 1.1e-15 57.8 0.0 3.2e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 PIK33372.1 - 4.7e-09 36.0 0.1 9.1e-09 35.1 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DDE_Tnp_IS240 PF13610.6 PIK33372.1 - 0.003 17.8 0.5 0.0063 16.7 0.5 1.5 1 0 0 1 1 1 1 DDE domain Tudor-knot PF11717.8 PIK33372.1 - 0.013 15.4 0.6 0.013 15.4 0.6 2.1 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 PIK33372.1 - 0.13 12.5 0.6 0.41 10.9 0.2 2.1 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 VWC PF00093.18 PIK33373.1 - 3.6e-20 72.0 55.5 9e-07 29.1 15.5 3.1 3 0 0 3 3 3 3 von Willebrand factor type C domain TILa PF12714.7 PIK33373.1 - 0.6 10.1 54.2 0.23 11.4 13.7 4.1 2 1 2 4 4 4 0 TILa domain VWC PF00093.18 PIK33374.1 - 6.4e-33 112.9 75.3 1.4e-11 44.5 15.6 5.1 5 0 0 5 5 5 5 von Willebrand factor type C domain TILa PF12714.7 PIK33374.1 - 0.0035 17.3 7.4 0.0035 17.3 7.4 5.1 5 1 0 5 5 5 3 TILa domain OATP PF03137.20 PIK33376.1 - 6.1e-25 87.5 0.1 9.1e-25 86.9 0.1 1.2 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family ECF_trnsprt PF12822.7 PIK33376.1 - 0.0054 16.8 0.5 0.0073 16.4 0.5 1.3 1 1 0 1 1 1 1 ECF transporter, substrate-specific component Trp_oprn_chp PF09534.10 PIK33376.1 - 0.14 12.0 0.1 0.24 11.2 0.1 1.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4199 PF13858.6 PIK33376.1 - 0.56 10.6 3.1 0.26 11.7 0.6 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) OATP PF03137.20 PIK33377.1 - 3e-48 164.5 0.1 3.5e-48 164.2 0.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK33377.1 - 3.4e-08 33.5 4.2 7e-08 32.5 4.2 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 PIK33377.1 - 4.1e-05 22.7 6.3 5.6e-05 22.2 6.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Kazal_1 PF00050.21 PIK33377.1 - 0.00068 19.6 6.7 0.0013 18.7 6.7 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain OATP PF03137.20 PIK33378.1 - 2.7e-17 62.3 0.1 3.7e-17 61.8 0.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family PseudoU_synth_2 PF00849.22 PIK33379.1 - 0.00033 20.8 0.2 0.00041 20.5 0.2 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase PCSK9_C1 PF18459.1 PIK33379.1 - 0.13 12.4 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain DIX PF00778.17 PIK33379.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 DIX domain COG5 PF10392.9 PIK33380.1 - 1.6e-20 73.6 4.4 4.3e-20 72.2 0.4 2.6 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.11 PIK33380.1 - 1.2e-06 28.5 3.9 7.4e-06 26.0 0.3 3.5 3 2 2 5 5 5 1 Vps51/Vps67 Fib_alpha PF08702.10 PIK33380.1 - 0.00015 21.9 0.8 0.31 11.2 0.3 3.4 2 2 1 3 3 3 2 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 PIK33380.1 - 0.0085 16.5 0.7 0.34 11.4 0.0 3.2 3 1 0 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF3135 PF11333.8 PIK33380.1 - 0.016 15.4 2.3 0.15 12.4 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3135) CLZ PF16526.5 PIK33380.1 - 0.15 12.4 0.2 0.15 12.4 0.2 3.2 4 1 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels COG2 PF06148.11 PIK33380.1 - 0.28 11.3 0.0 0.28 11.3 0.0 2.8 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ADIP PF11559.8 PIK33380.1 - 0.59 10.2 8.1 0.049 13.7 1.2 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HrpB7 PF09486.10 PIK33380.1 - 3.2 8.1 8.4 0.36 11.2 2.3 2.4 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Vps62 PF06101.11 PIK33381.1 - 4.3e-24 84.7 0.0 2.5e-11 42.6 0.0 2.2 1 1 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 ETX_MTX2 PF03318.13 PIK33381.1 - 4.5e-08 33.2 9.3 6.5e-08 32.6 9.3 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK33381.1 - 2.9e-06 26.8 5.7 4.4e-06 26.2 5.7 1.2 1 0 0 1 1 1 1 Aerolysin toxin DUF5300 PF17224.3 PIK33381.1 - 0.0046 17.2 0.6 0.014 15.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5300) CPCFC PF17223.3 PIK33382.1 - 2.4 8.0 21.9 2.2e+02 1.7 0.1 8.6 9 0 0 9 9 9 0 Cuticle protein CPCFC Helicase_C PF00271.31 PIK33383.1 - 6.4e-13 49.0 0.0 1.7e-12 47.6 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RIG-I_C PF18119.1 PIK33383.1 - 3.5e-09 36.8 0.9 5.7e-09 36.1 0.9 1.5 1 1 0 1 1 1 1 RIG-I receptor C-terminal domain RIG-I_C-RD PF11648.8 PIK33384.1 - 5.3e-28 97.6 2.6 8.3e-28 97.0 2.6 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I Yippee-Mis18 PF03226.14 PIK33384.1 - 0.00017 21.8 1.4 0.00023 21.3 1.4 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PAX PF00292.18 PIK33385.1 - 3.6e-65 217.5 0.5 7.5e-65 216.5 0.5 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 PIK33385.1 - 9.5e-05 22.1 0.0 0.00034 20.3 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 PIK33385.1 - 0.00014 22.4 0.9 0.007 16.9 0.0 2.9 2 1 1 3 3 3 2 Homeodomain-like domain MYT1 PF08474.11 PIK33385.1 - 0.17 11.8 4.7 4.5 7.1 0.7 2.2 1 1 0 2 2 2 0 Myelin transcription factor 1 WH1 PF00568.23 PIK33386.1 - 7.7e-17 61.2 0.1 9.5e-17 60.9 0.1 1.1 1 0 0 1 1 1 1 WH1 domain Sulfatase PF00884.23 PIK33387.1 - 7.3e-79 265.4 0.1 1.3e-78 264.6 0.0 1.4 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 PIK33387.1 - 4.3e-29 101.8 3.4 7.7e-29 100.9 3.4 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK33387.1 - 1.8e-07 31.1 0.1 6.2e-06 26.0 0.1 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK33387.1 - 0.0036 16.0 0.0 0.0045 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 PIK33387.1 - 0.023 13.8 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF4976 PF16347.5 PIK33387.1 - 0.077 13.3 0.2 0.077 13.3 0.2 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4976) 7tm_2 PF00002.24 PIK33388.1 - 4e-28 98.3 19.1 6.2e-28 97.7 19.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK33388.1 - 9.1e-17 61.3 2.3 1.7e-16 60.5 2.3 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.21 PIK33388.1 - 0.012 14.9 12.8 0.019 14.3 12.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CrgA PF06781.12 PIK33388.1 - 3 7.9 9.4 0.31 11.1 0.2 3.1 3 0 0 3 3 3 0 Cell division protein CrgA Phage_DsbA PF11126.8 PIK33389.1 - 2.7 8.3 6.8 42 4.5 0.1 4.4 3 2 1 5 5 5 0 Transcriptional regulator DsbA S1 PF00575.23 PIK33390.1 - 0.47 10.8 10.0 2.7 8.4 0.7 2.9 3 0 0 3 3 3 0 S1 RNA binding domain zf-CCHC PF00098.23 PIK33392.1 - 1e-06 28.6 16.2 0.0007 19.6 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK33392.1 - 0.00062 19.5 7.7 0.11 12.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK33392.1 - 0.023 14.5 0.2 0.023 14.5 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK33392.1 - 0.024 14.4 0.8 0.024 14.4 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK33392.1 - 0.043 13.6 11.3 5.4 6.8 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK33392.1 - 0.13 12.2 18.2 0.26 11.3 1.2 4.0 3 1 2 5 5 5 0 Zinc knuckle RVT_1 PF00078.27 PIK33394.1 - 4.4e-06 26.4 0.0 8.6e-06 25.4 0.0 1.5 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aldolase_II PF00596.21 PIK33395.1 - 1.8e-40 138.9 0.0 2.2e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Phage_TTP_1 PF04630.12 PIK33395.1 - 0.097 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Phage tail tube protein Guanylate_cyc PF00211.20 PIK33396.1 - 4.1e-62 209.1 0.0 7.7e-62 208.2 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK33396.1 - 0.0026 17.3 0.3 0.0026 17.3 0.3 1.9 2 0 0 2 2 2 1 Heme NO binding associated FPRL1_inhibitor PF16104.5 PIK33396.1 - 0.21 11.8 3.5 17 5.6 3.1 2.7 2 0 0 2 2 2 0 Formyl peptide receptor-like 1 inhibitory protein IL2 PF00715.17 PIK33396.1 - 0.23 11.4 2.0 9.1 6.2 0.1 2.7 1 1 1 2 2 2 0 Interleukin 2 Snf7 PF03357.21 PIK33397.1 - 7.9e-40 136.3 20.3 7.9e-40 136.3 20.3 1.9 1 1 1 2 2 2 1 Snf7 Ribophorin_II PF05817.14 PIK33397.1 - 0.079 11.5 4.7 0.088 11.3 4.7 1.0 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II PSD4 PF07631.11 PIK33397.1 - 0.12 13.0 2.3 0.25 11.9 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) zf-ZPR1 PF03367.13 PIK33397.1 - 0.19 11.6 8.6 0.039 13.8 2.7 2.4 1 1 2 3 3 3 0 ZPR1 zinc-finger domain FUSC PF04632.12 PIK33397.1 - 0.24 9.9 2.4 0.25 9.8 1.8 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family EnY2 PF10163.9 PIK33397.1 - 0.24 11.8 7.4 0.12 12.7 0.6 2.6 1 1 0 2 2 2 0 Transcription factor e(y)2 Unstab_antitox PF09720.10 PIK33397.1 - 0.32 11.1 12.6 0.31 11.1 0.6 3.3 3 0 0 3 3 3 0 Putative addiction module component QueH PF02677.14 PIK33397.1 - 0.33 11.0 4.0 0.52 10.4 4.0 1.4 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH HlyD_2 PF12700.7 PIK33397.1 - 0.44 9.2 11.4 0.64 8.7 11.4 1.3 1 1 0 1 1 1 0 HlyD family secretion protein Cauli_AT PF03233.13 PIK33397.1 - 0.61 10.0 9.2 0.15 12.0 2.7 2.4 1 1 1 2 2 2 0 Aphid transmission protein YlqD PF11068.8 PIK33397.1 - 1 9.7 15.8 0.094 13.1 8.7 2.2 1 1 1 2 2 2 0 YlqD protein MogR_DNAbind PF12181.8 PIK33398.1 - 0.049 13.5 2.4 0.075 12.9 0.1 2.2 2 0 0 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) Gal_Lectin PF02140.18 PIK33399.1 - 1.2e-14 54.5 0.9 1.7e-14 54.0 0.4 1.6 1 1 0 1 1 1 1 Galactose binding lectin domain Pro_racemase PF05544.11 PIK33400.1 - 2.3e-96 322.7 0.3 2.6e-96 322.5 0.3 1.0 1 0 0 1 1 1 1 Proline racemase DAP_epimerase PF01678.19 PIK33400.1 - 0.024 14.8 0.2 0.062 13.5 0.0 1.8 2 0 0 2 2 2 0 Diaminopimelate epimerase Pro_racemase PF05544.11 PIK33402.1 - 8.3e-45 153.2 0.3 9.2e-45 153.1 0.3 1.0 1 0 0 1 1 1 1 Proline racemase DAP_epimerase PF01678.19 PIK33402.1 - 0.097 12.9 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelate epimerase Pro_racemase PF05544.11 PIK33403.1 - 2.8e-43 148.2 0.2 3.4e-43 148.0 0.2 1.0 1 0 0 1 1 1 1 Proline racemase Glutaredoxin PF00462.24 PIK33404.1 - 2.2e-17 63.0 0.0 4e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Sushi PF00084.20 PIK33405.1 - 4.6e-09 36.7 26.1 0.0015 19.1 0.9 5.3 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) TUDOR PF00567.24 PIK33406.1 - 1.9e-12 47.3 0.0 3.1e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 PIK33406.1 - 5e-05 23.0 0.1 8.5e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 KH domain UPA PF17217.3 PIK33407.1 - 1.4e-13 50.9 0.2 3.4e-13 49.7 0.1 1.7 2 0 0 2 2 2 1 UPA domain Death PF00531.22 PIK33407.1 - 4.3e-06 26.8 0.1 8.2e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Death domain Auxin_BP PF02041.16 PIK33407.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Auxin binding protein Trypsin PF00089.26 PIK33408.1 - 2.6e-13 50.3 0.0 2.8e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK33408.1 - 0.011 16.1 0.0 0.012 16.0 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Fz PF01392.22 PIK33409.1 - 8.6e-06 26.4 2.6 8.6e-06 26.4 2.6 1.8 1 1 1 2 2 2 1 Fz domain CUB PF00431.20 PIK33409.1 - 0.00034 20.9 0.0 0.00091 19.5 0.0 1.7 1 1 0 1 1 1 1 CUB domain Glypican PF01153.19 PIK33409.1 - 0.89 8.3 3.3 1.1 8.0 3.3 1.1 1 0 0 1 1 1 0 Glypican Toxin_12 PF07740.12 PIK33409.1 - 6.4 7.6 8.0 4 8.2 4.5 2.6 2 1 0 2 2 2 0 Ion channel inhibitory toxin Trypsin PF00089.26 PIK33410.1 - 2.7e-48 164.7 0.0 3.5e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK33410.1 - 2.8e-10 40.3 11.3 5.5e-10 39.3 11.3 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 PIK33410.1 - 6.6e-09 36.2 0.0 1.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK33410.1 - 0.0011 19.9 0.0 0.0015 19.4 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 PIK33411.1 - 9.9e-76 254.4 0.1 1.4e-75 254.0 0.1 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK33411.1 - 0.00013 22.9 0.0 0.00031 21.7 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 PIK33411.1 - 0.00039 20.8 0.0 0.00072 19.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 PIK33412.1 - 5.5e-27 95.0 0.4 9.6e-27 94.2 0.4 1.4 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK33412.1 - 5.7e-12 45.6 27.9 2.6e-09 37.1 15.5 3.5 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Speriolin_C PF15059.6 PIK33413.1 - 3.7e-13 49.8 0.3 1.2e-12 48.2 0.3 1.8 1 0 0 1 1 1 1 Speriolin C-terminus TPK_B1_binding PF04265.14 PIK33414.1 - 1.8e-22 78.8 0.2 2.8e-22 78.2 0.2 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.16 PIK33414.1 - 9.9e-22 77.2 0.0 3.1e-21 75.7 0.0 1.7 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain PI-PLC-C1 PF16670.5 PIK33414.1 - 0.05 12.7 0.0 0.066 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent AA_permease_2 PF13520.6 PIK33416.1 - 2.7e-18 66.0 15.7 3.1e-18 65.8 15.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK33416.1 - 1.1e-06 27.6 9.3 1.5e-06 27.1 9.3 1.2 1 0 0 1 1 1 1 Amino acid permease DUF3040 PF11239.8 PIK33416.1 - 0.21 11.9 7.5 0.24 11.7 5.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) AA_permease_2 PF13520.6 PIK33417.1 - 2.1e-13 49.9 14.5 2.3e-13 49.8 14.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK33417.1 - 2.3e-06 26.5 13.7 2.7e-06 26.3 13.7 1.0 1 0 0 1 1 1 1 Amino acid permease PMP22_Claudin PF00822.20 PIK33417.1 - 0.076 12.9 2.0 0.094 12.6 2.0 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family AA_permease_2 PF13520.6 PIK33418.1 - 8.1e-17 61.2 13.5 9.5e-17 60.9 13.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK33418.1 - 4.3e-07 28.9 13.7 4.8e-07 28.7 13.7 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 PIK33418.1 - 0.011 14.8 9.6 0.012 14.6 9.6 1.0 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family RVT_1 PF00078.27 PIK33419.1 - 1.7e-05 24.5 0.0 4.3e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) BING4CT PF08149.11 PIK33419.1 - 0.027 14.3 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 BING4CT (NUC141) domain RT_RNaseH_2 PF17919.1 PIK33420.1 - 9.8e-34 115.4 0.0 1.6e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33420.1 - 2.8e-25 88.6 0.0 5e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Sulfatase_C PF14707.6 PIK33421.1 - 5.7e-30 104.6 0.0 7.3e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK33421.1 - 8.4e-24 84.5 0.0 1.4e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Bys1 PF04681.12 PIK33421.1 - 0.0042 17.0 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Copine PF07002.16 PIK33422.1 - 5e-67 225.5 0.0 7.3e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 PIK33422.1 - 0.0002 21.6 0.0 0.00026 21.2 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 PIK33422.1 - 0.0093 16.2 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain EamA PF00892.20 PIK33424.1 - 2.8e-06 27.5 22.0 2.1e-05 24.7 23.4 1.7 2 0 0 2 2 2 1 EamA-like transporter family CcmD PF04995.14 PIK33424.1 - 0.072 13.2 0.7 0.29 11.2 0.0 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Gram_pos_anchor PF00746.21 PIK33424.1 - 0.83 9.7 2.2 15 5.6 0.5 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif ABC2_membrane_2 PF12679.7 PIK33424.1 - 5 6.3 14.3 15 4.8 14.3 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Integrase_1 PF12835.7 PIK33425.1 - 0.12 12.5 0.1 0.32 11.1 0.1 1.7 1 0 0 1 1 1 0 Integrase DNA_methylase PF00145.17 PIK33426.1 - 2.4e-26 92.9 0.5 1e-24 87.5 0.5 2.1 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Choline_transpo PF04515.12 PIK33427.1 - 3.1e-91 306.0 35.9 3.1e-91 306.0 35.9 3.1 2 2 0 2 2 2 1 Plasma-membrane choline transporter ABC_tran_Xtn PF12848.7 PIK33429.1 - 9.8e-19 67.2 1.6 9.8e-19 67.2 1.6 2.0 2 1 0 2 2 2 1 ABC transporter DUF587 PF04532.12 PIK33429.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF587) p450 PF00067.22 PIK33431.1 - 3.6e-90 302.9 0.1 4.7e-90 302.6 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 FEZ PF07763.13 PIK33431.1 - 0.056 13.2 0.4 0.082 12.6 0.4 1.3 1 0 0 1 1 1 0 FEZ-like protein LRR_8 PF13855.6 PIK33432.1 - 3.4e-12 45.9 6.4 1.4e-05 24.8 0.0 4.8 2 1 3 5 5 5 4 Leucine rich repeat LRRNT PF01462.18 PIK33432.1 - 4.8e-06 26.1 1.9 4.8e-06 26.1 1.9 2.2 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 PIK33432.1 - 0.00076 19.8 2.1 0.0017 18.8 0.6 2.5 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_4 PF12799.7 PIK33432.1 - 0.1 13.1 12.3 1.6 9.2 0.9 4.5 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) KKLCAg1 PF15204.6 PIK33432.1 - 0.13 12.3 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 LRR_8 PF13855.6 PIK33433.1 - 1.4e-12 47.2 6.6 0.00013 21.7 0.1 5.2 3 2 1 4 4 4 3 Leucine rich repeat LRRNT PF01462.18 PIK33433.1 - 1e-06 28.2 1.9 1e-06 28.2 1.9 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 PIK33433.1 - 3.3e-05 24.2 15.7 0.3 11.6 1.5 6.2 5 1 0 6 6 6 3 Leucine Rich repeats (2 copies) LRRCT PF01463.24 PIK33433.1 - 0.02 15.4 0.0 0.079 13.5 0.0 2.1 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Ig_2 PF13895.6 PIK33433.1 - 0.057 13.8 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain LSR PF05624.14 PIK33433.1 - 0.19 11.7 8.4 0.044 13.8 4.8 1.7 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) I-set PF07679.16 PIK33435.1 - 0.001 19.1 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33435.1 - 0.013 16.0 0.3 0.035 14.7 0.1 1.7 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK33435.1 - 0.023 14.9 1.5 0.25 11.5 0.1 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Nudix_N_2 PF14803.6 PIK33436.1 - 0.02 14.8 0.9 0.58 10.1 0.0 2.7 3 0 0 3 3 3 0 Nudix N-terminal NACHT PF05729.12 PIK33437.1 - 4.7e-16 59.1 0.0 1.4e-15 57.6 0.0 1.8 2 0 0 2 2 2 1 NACHT domain C2-set_2 PF08205.12 PIK33437.1 - 8.9e-07 28.9 2.3 0.0015 18.5 0.1 2.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK33437.1 - 3.5e-06 27.5 3.2 0.024 15.2 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK33437.1 - 6.7e-06 26.4 1.9 0.16 12.3 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain AAA_25 PF13481.6 PIK33437.1 - 0.022 14.3 0.0 0.08 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain V-set PF07686.17 PIK33437.1 - 0.031 14.5 0.3 0.47 10.7 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin V-set domain DAP3 PF10236.9 PIK33437.1 - 0.046 12.9 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK33437.1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ig PF00047.25 PIK33437.1 - 0.19 11.9 3.4 3.3 8.0 0.0 3.3 4 0 0 4 4 4 0 Immunoglobulin domain HYR PF02494.16 PIK33438.1 - 3.5e-21 75.3 7.2 5.1e-17 62.0 0.6 2.4 1 1 1 2 2 2 2 HYR domain CUB PF00431.20 PIK33438.1 - 3.3e-08 33.9 0.5 3.2e-07 30.7 0.2 2.3 2 0 0 2 2 2 1 CUB domain CW_binding_1 PF01473.20 PIK33438.1 - 0.072 13.5 0.2 0.22 11.9 0.2 1.8 1 0 0 1 1 1 0 Putative cell wall binding repeat Na_Pi_cotrans PF02690.15 PIK33439.1 - 2.6e-34 118.3 28.1 6.3e-22 78.2 8.4 2.6 2 1 0 3 3 3 2 Na+/Pi-cotransporter WAP PF00095.21 PIK33440.1 - 1.9e-05 24.9 10.1 3.1e-05 24.3 10.1 1.3 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Thyroglobulin_1 PF00086.18 PIK33441.1 - 1e-08 34.7 2.2 1.1e-08 34.6 0.1 1.9 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat fn3 PF00041.21 PIK33442.1 - 1.1e-11 44.8 0.1 2.3e-06 27.8 0.0 2.4 2 1 0 2 2 2 2 Fibronectin type III domain Cadherin PF00028.17 PIK33443.1 - 6e-18 65.1 1.7 9.9e-08 32.3 0.1 4.5 5 0 0 5 5 5 2 Cadherin domain Cadherin_3 PF16184.5 PIK33443.1 - 0.016 15.2 0.4 0.18 11.8 0.1 2.9 2 0 0 2 2 2 0 Cadherin-like Cadherin_4 PF17803.1 PIK33443.1 - 4.5 8.0 7.5 5.8 7.6 0.2 3.8 4 0 0 4 4 4 0 Bacterial cadherin-like domain Cadherin PF00028.17 PIK33444.1 - 1.4e-09 38.2 0.3 2.6e-06 27.8 0.1 2.2 2 0 0 2 2 2 2 Cadherin domain DUF4959 PF16323.5 PIK33444.1 - 0.047 14.0 0.1 0.075 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4959) Pkinase_Tyr PF07714.17 PIK33445.1 - 2.2e-43 148.4 0.0 2.9e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK33445.1 - 8.3e-18 64.7 0.0 1.2e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RT_RNaseH_2 PF17919.1 PIK33446.1 - 8.7e-33 112.3 0.1 1.5e-32 111.6 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33446.1 - 3e-25 88.5 0.0 6.1e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK33447.1 - 4.1e-22 78.6 0.0 7.8e-21 74.5 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK33447.1 - 9.8e-18 64.0 0.6 1.8e-17 63.1 0.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK33447.1 - 0.00039 20.1 0.0 0.0024 17.6 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK33447.1 - 0.033 14.4 0.8 0.068 13.4 0.8 1.5 1 0 0 1 1 1 0 H2C2 zinc finger HPS3_Mid PF14762.6 PIK33448.1 - 3.8e-16 58.8 0.8 9.6e-16 57.5 0.8 1.7 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, middle region HPS3_C PF14763.6 PIK33448.1 - 0.00052 19.5 1.1 0.00052 19.5 1.1 3.1 2 2 1 3 3 3 2 Hermansky-Pudlak syndrome 3, C-terminal Filament PF00038.21 PIK33449.1 - 2e-16 60.5 48.2 4.4e-15 56.1 48.2 2.0 1 1 0 1 1 1 1 Intermediate filament protein TRAF_BIRC3_bd PF16673.5 PIK33449.1 - 0.29 10.9 17.5 1.4 8.7 0.8 4.1 3 1 1 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain DUF812 PF05667.11 PIK33449.1 - 1.2 7.9 36.2 2.1 7.2 36.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Spidroin_N PF16763.5 PIK33449.1 - 3.5 7.7 6.7 4.7 7.3 0.1 3.2 3 2 0 3 3 3 0 Major ampullate spidroin 1, spider silk protein 1, N-term BORCS6 PF10157.9 PIK33449.1 - 4.7 7.4 12.0 0.34 11.1 0.8 3.2 1 1 3 4 4 4 0 BLOC-1-related complex sub-unit 6 Prominin PF05478.11 PIK33449.1 - 5.6 4.8 24.2 0.1 10.6 6.6 2.9 1 1 1 3 3 3 0 Prominin GHMP_kinases_C PF08544.13 PIK33449.1 - 6.2 7.3 6.7 2.8 8.3 1.4 3.0 3 1 1 4 4 4 0 GHMP kinases C terminal bZIP_1 PF00170.21 PIK33449.1 - 6.8 6.9 34.5 0.91 9.7 2.5 6.4 4 3 3 7 7 7 0 bZIP transcription factor Nucleoporin_FG2 PF15967.5 PIK33451.1 - 4.2e-91 306.3 24.9 6.4e-91 305.7 24.9 1.2 1 0 0 1 1 1 1 Nucleoporin FG repeated region GCP_N_terminal PF17681.1 PIK33451.1 - 0.00077 19.2 1.1 0.0012 18.6 1.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Spectrin PF00435.21 PIK33451.1 - 0.014 15.9 3.4 0.077 13.5 2.0 2.3 2 1 0 2 2 2 0 Spectrin repeat PHM7_cyt PF14703.6 PIK33451.1 - 0.02 15.2 3.5 0.025 14.8 2.2 1.8 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF948 PF06103.11 PIK33451.1 - 0.12 12.7 1.2 6.4 7.1 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2383 PF09537.10 PIK33451.1 - 0.14 12.5 0.3 0.14 12.5 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) NBP1 PF08537.10 PIK33451.1 - 0.33 10.3 4.9 0.47 9.8 4.9 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Cep57_MT_bd PF06657.13 PIK33451.1 - 0.41 11.1 2.3 1.1 9.7 2.3 1.7 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 SKA1 PF07160.12 PIK33451.1 - 4.2 7.2 7.4 5.5 6.8 0.7 2.6 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 BBS2_Mid PF14783.6 PIK33452.1 - 2.6e-07 30.6 0.0 5.4e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region BBS2_C PF14782.6 PIK33452.1 - 0.00048 19.0 0.1 0.0021 16.9 0.0 2.1 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal Septin PF00735.18 PIK33453.1 - 2.7e-35 122.0 0.5 2.9e-35 121.9 0.5 1.0 1 0 0 1 1 1 1 Septin TSNAXIP1_N PF15739.5 PIK33453.1 - 0.014 15.7 0.1 0.015 15.7 0.1 1.2 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus MFS_1_like PF12832.7 PIK33454.1 - 1e-16 60.8 1.1 1e-16 60.8 1.1 2.0 2 0 0 2 2 2 1 MFS_1 like family MFS_1 PF07690.16 PIK33454.1 - 0.00015 20.9 24.4 0.00056 18.9 4.7 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 PIK33454.1 - 0.0011 17.4 2.2 0.0094 14.3 0.9 2.0 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family BaxI_1 PF12811.7 PIK33454.1 - 0.0015 18.1 0.1 0.0015 18.1 0.1 2.2 2 1 0 2 2 2 1 Bax inhibitor 1 like Pyridoxal_deC PF00282.19 PIK33455.1 - 3.3e-11 42.5 0.0 1.8e-09 36.8 0.0 2.5 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain DUF1103 PF06513.11 PIK33455.1 - 0.016 14.9 2.6 0.038 13.6 2.6 1.6 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Thioredoxin_6 PF13848.6 PIK33455.1 - 0.038 13.9 0.0 14 5.5 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain COMM_domain PF07258.14 PIK33455.1 - 0.92 9.7 3.1 58 3.9 0.0 3.7 4 0 0 4 4 4 0 COMM domain Ribosomal_S2 PF00318.20 PIK33456.1 - 1.3e-14 54.0 0.0 8.8e-14 51.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S2 40S_SA_C PF16122.5 PIK33456.1 - 3.4e-09 38.0 5.9 6.9e-09 37.0 5.9 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Glyco_transf_54 PF04666.13 PIK33457.1 - 8.7e-89 297.2 0.4 1.1e-88 296.9 0.4 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region RVT_1 PF00078.27 PIK33458.1 - 9.4e-08 31.8 0.0 1.7e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1539 PF07560.11 PIK33458.1 - 0.066 13.3 0.5 0.22 11.6 0.3 1.9 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) rve PF00665.26 PIK33459.1 - 6.8e-18 65.0 0.0 1.1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK33459.1 - 6.4e-13 48.6 1.1 1.4e-12 47.5 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33459.1 - 0.042 14.1 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 H2C2 zinc finger AphA_like PF14557.6 PIK33459.1 - 0.062 13.0 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator RVT_1 PF00078.27 PIK33460.1 - 3.5e-14 52.9 0.1 8.6e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3896 PF13035.6 PIK33460.1 - 0.029 14.5 0.1 0.12 12.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) AAA_25 PF13481.6 PIK33461.1 - 0.0061 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK33461.1 - 0.05 13.5 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MBOAT PF03062.19 PIK33462.1 - 4.5e-08 32.8 0.2 5.3e-08 32.6 0.2 1.0 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT PF03062.19 PIK33463.1 - 1.1e-08 34.8 6.5 1.1e-08 34.8 6.5 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family tRNA_int_endo PF01974.17 PIK33464.1 - 1.2e-19 70.1 0.1 2.2e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 PIK33464.1 - 0.0035 17.0 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Presenilin PF01080.17 PIK33464.1 - 0.045 12.5 0.1 0.048 12.4 0.1 1.1 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 PIK33464.1 - 0.18 10.8 1.0 0.23 10.4 1.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein Sec62 PF03839.16 PIK33464.1 - 5.1 6.5 8.0 7.1 6.1 8.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 HYR PF02494.16 PIK33465.1 - 4.1e-150 488.5 74.9 3.2e-20 72.2 5.6 12.2 12 0 0 12 12 12 12 HYR domain SEA PF01390.20 PIK33465.1 - 1.7e-08 34.5 0.0 1.3e-07 31.6 0.0 2.4 2 0 0 2 2 2 1 SEA domain EGF PF00008.27 PIK33465.1 - 2.9e-05 24.3 8.8 4.8e-05 23.6 7.2 2.2 2 0 0 2 2 2 1 EGF-like domain Cohesin PF00963.18 PIK33465.1 - 0.0017 18.6 0.7 7.3 6.8 0.0 4.2 3 0 0 3 3 3 2 Cohesin domain hEGF PF12661.7 PIK33465.1 - 0.0035 17.9 4.2 0.0035 17.9 4.2 2.2 2 0 0 2 2 2 1 Human growth factor-like EGF EGF_CA PF07645.15 PIK33465.1 - 2.5 8.4 8.3 6.7 7.0 8.3 1.7 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF_3 PF12947.7 PIK33465.1 - 4.2 7.6 8.1 13 6.0 8.1 1.9 1 0 0 1 1 1 0 EGF domain cEGF PF12662.7 PIK33465.1 - 4.2 7.4 5.7 0.86 9.6 0.5 2.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK33465.1 - 5.8 7.4 11.3 15 6.1 11.3 1.7 1 0 0 1 1 1 0 EGF-like domain rve PF00665.26 PIK33466.1 - 3.7e-25 88.4 0.0 5.8e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK33466.1 - 0.00031 20.4 0.0 0.00062 19.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK33467.1 - 2.3e-29 102.5 0.0 3.6e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK33467.1 - 4.8e-06 27.0 0.0 1.3e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK33467.1 - 8.4e-06 26.3 0.0 2.3e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Spuma_A9PTase PF03539.14 PIK33467.1 - 0.00074 19.7 0.0 0.65 10.1 0.0 2.5 1 1 1 2 2 2 2 Spumavirus aspartic protease (A9) RVP PF00077.20 PIK33467.1 - 0.01 16.2 0.0 0.038 14.3 0.0 1.9 2 0 0 2 2 2 0 Retroviral aspartyl protease HalX PF08663.10 PIK33468.1 - 0.079 13.3 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 HalX domain Phage_int_SAM_1 PF02899.17 PIK33469.1 - 0.00012 22.4 1.0 0.0003 21.0 0.1 2.1 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK33469.1 - 0.00038 20.9 0.0 0.00079 19.9 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK33469.1 - 0.00061 19.6 0.0 0.0021 17.8 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family RVT_1 PF00078.27 PIK33470.1 - 6.5e-19 68.3 0.0 1e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PhageMin_Tail PF10145.9 PIK33471.1 - 0.13 12.1 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein DUF4231 PF14015.6 PIK33473.1 - 0.039 14.4 3.5 2.2 8.8 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) TRP PF06011.12 PIK33473.1 - 6.3 5.4 10.9 0.15 10.8 1.5 1.9 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Ephrin_rec_like PF07699.13 PIK33474.1 - 0.00048 19.8 23.3 0.00079 19.1 1.5 4.6 3 2 1 4 4 4 3 Putative ephrin-receptor like Furin-like_2 PF15913.5 PIK33474.1 - 0.0015 18.6 20.3 0.008 16.3 1.5 3.4 2 1 1 3 3 3 3 Furin-like repeat, cysteine-rich FixQ PF05545.11 PIK33474.1 - 0.055 13.5 0.1 0.085 12.8 0.1 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ zf-met PF12874.7 PIK33475.1 - 7.4e-07 29.4 3.7 9.5e-07 29.0 1.6 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK33475.1 - 9.4e-05 22.6 1.6 0.00026 21.2 1.6 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.12 PIK33475.1 - 8.7 6.5 7.2 1.2 9.3 2.6 2.0 2 0 0 2 2 2 0 DBF zinc finger EamA PF00892.20 PIK33477.1 - 7.1e-08 32.7 17.5 1.2e-06 28.7 2.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family Phosphodiest PF01663.22 PIK33478.1 - 1.8e-80 271.3 0.1 2.4e-80 270.8 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Endonuclease_NS PF01223.23 PIK33478.1 - 3.2e-07 30.4 0.0 4.5e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Metalloenzyme PF01676.18 PIK33478.1 - 0.02 14.2 0.0 0.048 13.0 0.0 1.6 1 0 0 1 1 1 0 Metalloenzyme superfamily Sulfatase PF00884.23 PIK33478.1 - 0.021 14.2 0.0 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Sulfatase THAP PF05485.12 PIK33479.1 - 1.8e-11 44.8 2.6 1.8e-11 44.8 2.6 1.9 2 0 0 2 2 2 1 THAP domain HEAT PF02985.22 PIK33481.1 - 0.0024 18.0 0.5 0.52 10.7 0.1 3.2 2 0 0 2 2 2 1 HEAT repeat HEAT_EZ PF13513.6 PIK33481.1 - 0.0094 16.4 3.1 0.042 14.4 0.3 3.2 3 1 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.6 PIK33481.1 - 0.035 14.5 1.8 0.098 13.1 0.2 2.5 3 1 0 3 3 3 0 HEAT repeats Vac14_Fab1_bd PF12755.7 PIK33481.1 - 0.095 13.3 0.6 12 6.6 0.0 3.4 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK33481.1 - 0.89 9.1 4.7 5.4 6.5 0.0 2.8 3 0 0 3 3 3 0 CLASP N terminal DUF3385 PF11865.8 PIK33482.1 - 3.3e-12 46.6 0.2 1.6e-10 41.2 0.1 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 PIK33482.1 - 3.9e-09 36.8 1.0 0.16 12.5 0.0 5.0 4 1 1 5 5 5 3 HEAT-like repeat HEAT PF02985.22 PIK33482.1 - 9.2e-09 34.8 0.3 0.0047 17.1 0.1 4.7 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.23 PIK33482.1 - 3.4e-07 30.1 0.3 0.0055 16.7 0.1 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK33482.1 - 3.5e-07 30.5 0.1 0.048 14.0 0.0 4.0 2 2 2 4 4 4 2 HEAT repeats Cnd1 PF12717.7 PIK33482.1 - 0.00016 21.8 0.1 2.6 8.1 0.0 3.6 1 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 PIK33482.1 - 0.0056 16.5 0.4 0.047 13.4 0.1 2.5 2 2 0 2 2 2 1 TATA-binding protein interacting (TIP20) DUF937 PF06078.11 PIK33482.1 - 0.051 14.2 2.3 3.8 8.1 0.0 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF937) FAT PF02259.23 PIK33483.1 - 5.3e-116 387.6 4.1 6.4e-115 384.1 0.4 2.5 3 0 0 3 3 3 2 FAT domain DUF3385 PF11865.8 PIK33483.1 - 1.9e-23 83.2 0.1 5.6e-23 81.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) TPR_19 PF14559.6 PIK33483.1 - 0.0013 19.2 1.6 2.2 8.8 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK33483.1 - 0.0071 16.3 0.2 1.1 9.5 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Vac14_Fab1_bd PF12755.7 PIK33483.1 - 0.055 14.1 0.0 0.27 11.8 0.0 2.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region TPR_2 PF07719.17 PIK33483.1 - 0.4 10.9 6.7 18 5.8 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat C1q PF00386.21 PIK33484.1 - 2.1e-32 112.0 0.1 2.7e-32 111.7 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 PIK33484.1 - 4e-06 26.5 46.3 0.11 12.3 29.5 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Lipase_3 PF01764.25 PIK33485.1 - 1.8e-17 63.5 0.0 3.2e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 PIK33485.1 - 0.02 14.1 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PKD_channel PF08016.12 PIK33485.1 - 0.13 11.0 0.9 0.18 10.4 0.9 1.2 1 0 0 1 1 1 0 Polycystin cation channel DUF202 PF02656.15 PIK33485.1 - 1.8 9.1 3.7 5.6 7.5 3.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF202) LSM PF01423.22 PIK33486.1 - 9.8e-09 34.8 0.0 0.00044 19.9 0.0 2.4 2 0 0 2 2 2 2 LSM domain Ribosomal_S30 PF04758.14 PIK33486.1 - 0.84 9.9 5.6 0.66 10.2 0.7 2.8 3 0 0 3 3 3 0 Ribosomal protein S30 PHD PF00628.29 PIK33487.1 - 9.4e-08 31.8 12.0 1.3e-07 31.4 8.6 2.6 2 0 0 2 2 2 1 PHD-finger UCH PF00443.29 PIK33487.1 - 0.00019 21.0 2.2 0.00074 19.1 0.2 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Zf_RING PF16744.5 PIK33487.1 - 0.012 15.7 4.9 0.012 15.7 4.9 2.1 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_2 PF13831.6 PIK33487.1 - 0.21 11.2 8.3 0.047 13.2 1.7 2.7 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 PIK33487.1 - 0.89 9.5 7.4 0.44 10.5 2.6 2.7 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) MRC1 PF09444.10 PIK33488.1 - 0.57 10.7 4.5 0.6 10.6 3.7 1.4 1 1 0 1 1 1 0 MRC1-like domain Ribosomal_L37 PF08561.10 PIK33488.1 - 4.4 7.9 9.7 7.4 7.1 9.7 1.5 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L37 ZIP4_domain PF18292.1 PIK33489.1 - 1.2e-07 31.8 0.9 1.8e-07 31.3 0.9 1.2 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain ZIP4_domain PF18292.1 PIK33490.1 - 0.026 14.4 0.5 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Zinc transporter ZIP4 domain YscO-like PF16789.5 PIK33490.1 - 0.16 12.0 1.0 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 YscO-like protein ZIP4_domain PF18292.1 PIK33491.1 - 1.9e-16 60.4 2.1 1.5e-13 51.0 0.5 2.3 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain Zip PF02535.22 PIK33491.1 - 3.8e-06 26.3 5.1 4.7e-06 26.0 3.4 1.9 2 0 0 2 2 2 1 ZIP Zinc transporter MerE PF05052.12 PIK33491.1 - 0.041 13.8 0.2 0.09 12.7 0.2 1.5 1 0 0 1 1 1 0 MerE protein MOR2-PAG1_N PF14222.6 PIK33492.1 - 5.7e-72 243.4 4.9 2.6e-36 125.7 0.0 2.3 1 1 1 2 2 2 2 Cell morphogenesis N-terminal RVT_1 PF00078.27 PIK33493.1 - 1.9e-06 27.6 0.0 3.6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3638 PF12340.8 PIK33493.1 - 0.0087 15.4 0.0 0.036 13.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) Spectrin PF00435.21 PIK33493.1 - 0.12 12.9 0.1 4 8.0 0.0 2.7 2 0 0 2 2 2 0 Spectrin repeat HTH_45 PF14947.6 PIK33493.1 - 0.19 11.7 2.1 0.58 10.2 2.1 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix PNMA PF14893.6 PIK33494.1 - 6.5e-06 25.8 0.0 8.8e-06 25.3 0.0 1.2 1 1 0 1 1 1 1 PNMA CdiA_C PF18451.1 PIK33494.1 - 0.019 15.2 0.0 0.051 13.8 0.0 1.8 2 0 0 2 2 2 0 Contact-dependent growth inhibition CdiA C-terminal domain PqqD PF05402.12 PIK33494.1 - 0.12 12.7 0.0 0.61 10.4 0.0 2.2 1 1 1 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) RT_RNaseH_2 PF17919.1 PIK33495.1 - 2.3e-32 111.0 0.0 4.3e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33495.1 - 1.5e-29 102.3 0.0 3.7e-29 101.1 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK33495.1 - 1.6e-18 66.5 0.0 3.3e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33495.1 - 3.1e-05 24.1 0.0 6.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Bac_surface_Ag PF01103.23 PIK33496.1 - 7.9e-56 189.9 1.7 1e-55 189.5 1.7 1.1 1 0 0 1 1 1 1 Surface antigen Ribosomal_S5 PF00333.20 PIK33496.1 - 0.053 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain zf-CCHC PF00098.23 PIK33497.1 - 1.9e-07 30.8 18.2 0.0063 16.6 1.8 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK33497.1 - 0.0065 16.3 2.4 0.0065 16.3 2.4 3.3 2 1 1 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK33497.1 - 0.35 10.6 16.6 0.6 9.9 2.4 3.2 1 1 2 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK33497.1 - 0.43 10.3 11.5 0.57 10.0 3.1 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK33497.1 - 2.1 8.4 24.4 1.2 9.2 5.7 4.2 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK33497.1 - 7.6 6.5 9.3 1.1 9.2 1.7 2.8 1 1 1 2 2 2 0 Zinc knuckle zf-C3HC4_2 PF13923.6 PIK33497.1 - 8.2 6.4 11.9 2.1 8.3 8.7 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GON PF08685.11 PIK33498.1 - 0.00061 19.7 0.4 0.00093 19.1 0.4 1.3 1 0 0 1 1 1 1 GON domain Sacchrp_dh_NADP PF03435.18 PIK33499.1 - 4.1e-11 43.2 0.1 3.3e-05 24.1 0.0 2.3 1 1 1 2 2 2 2 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 PIK33500.1 - 1.3e-25 90.0 2.4 3.9e-18 65.6 0.1 2.9 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK33500.1 - 4.9e-14 52.4 0.4 3.4e-12 46.4 0.0 2.6 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK33500.1 - 3e-05 24.0 3.6 0.013 15.4 0.5 2.3 1 1 1 2 2 2 2 KR domain QRPTase_C PF01729.19 PIK33500.1 - 0.11 12.2 0.5 0.21 11.3 0.5 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain PIP5K PF01504.18 PIK33502.1 - 1.2e-15 57.5 0.0 1.3e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase IPK PF03770.16 PIK33503.1 - 1.1e-43 149.4 0.0 2.4e-43 148.3 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase MDM1 PF15501.6 PIK33503.1 - 0.0059 15.8 7.7 0.0086 15.3 7.7 1.2 1 0 0 1 1 1 1 Nuclear protein MDM1 GREB1 PF15782.5 PIK33503.1 - 0.11 9.6 3.9 0.14 9.2 3.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer zf-C2H2_2 PF12756.7 PIK33504.1 - 0.065 13.6 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF4661 PF15576.6 PIK33504.1 - 0.096 12.6 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) bVLRF1 PF18826.1 PIK33505.1 - 1.4e-55 187.2 0.1 6.9e-55 185.0 0.0 2.2 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor NodZ PF05830.11 PIK33505.1 - 0.074 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) BING4CT PF08149.11 PIK33506.1 - 5.5e-38 128.6 0.0 2.2e-36 123.5 0.0 3.3 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 PIK33506.1 - 1.5e-11 44.4 0.0 0.019 15.3 0.0 4.7 1 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK33506.1 - 1.7e-06 28.6 0.0 0.00021 22.0 0.0 4.0 5 0 0 5 5 5 1 WD domain, G-beta repeat MMS1_N PF10433.9 PIK33506.1 - 0.0024 16.6 0.0 0.0064 15.2 0.0 1.7 1 1 1 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term HECT PF00632.25 PIK33507.1 - 4.4e-93 312.1 0.1 1.6e-92 310.3 0.0 1.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) VWA_3 PF13768.6 PIK33508.1 - 5.4e-06 26.4 0.0 9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK33508.1 - 0.0016 19.1 0.0 0.0029 18.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK33508.1 - 0.013 15.7 0.0 0.02 15.2 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF1647 PF07801.11 PIK33509.1 - 9.1e-20 70.8 0.1 1.9e-19 69.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) GST_C_4 PF14834.6 PIK33509.1 - 0.0087 16.4 0.0 0.027 14.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Fijivirus_P9-2 PF06837.11 PIK33509.1 - 0.011 15.2 0.1 0.041 13.3 0.1 1.9 2 0 0 2 2 2 0 Fijivirus P9-2 protein Sof1 PF04158.14 PIK33510.1 - 3e-29 101.1 12.5 4.7e-29 100.5 12.5 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 PIK33510.1 - 2.5e-21 75.6 6.6 0.00056 20.7 0.2 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 PIK33510.1 - 3.4e-07 30.3 0.1 6.1e-05 23.0 0.0 3.0 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK33510.1 - 0.028 13.1 0.0 0.092 11.4 0.0 1.8 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 PIK33510.1 - 0.049 12.7 0.1 0.14 11.1 0.0 1.6 2 0 0 2 2 2 0 Coatomer WD associated region DUF1794 PF08768.11 PIK33510.1 - 0.065 13.2 0.0 0.44 10.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1794) BBS2_Mid PF14783.6 PIK33510.1 - 0.084 12.9 0.0 20 5.3 0.0 3.7 4 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region LRR_8 PF13855.6 PIK33511.1 - 1e-14 54.0 10.3 5.3e-13 48.5 7.8 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 PIK33511.1 - 8.4e-09 35.5 0.5 1.1e-08 35.1 0.5 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK33511.1 - 9e-06 25.9 2.1 9e-06 25.9 2.1 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK33511.1 - 0.044 14.3 12.2 5.1 8.0 0.1 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK33511.1 - 0.059 12.9 2.8 0.062 12.8 1.5 1.6 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK33511.1 - 0.23 11.6 1.5 2.7 8.3 0.0 3.0 2 1 0 2 2 2 0 Leucine Rich repeat DUF1932 PF09130.11 PIK33512.1 - 0.082 12.9 0.8 0.33 10.9 0.1 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF1932) Muted PF14942.6 PIK33512.1 - 2.1 8.7 38.3 0.2 12.0 16.5 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Synaptonemal_3 PF15191.6 PIK33512.1 - 9.7 6.0 12.0 2.5 7.9 0.4 3.6 3 1 0 3 3 3 0 Synaptonemal complex central element protein 3 PRTase_1 PF11202.8 PIK33513.1 - 0.71 9.1 5.0 0.49 9.6 3.6 1.4 1 1 0 1 1 1 0 Phosphoribosyl transferase (PRTase) Rota_VP2 PF05087.12 PIK33513.1 - 1.1 7.3 9.1 1.3 7.0 9.1 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein DUF787 PF05619.11 PIK33513.1 - 2.5 7.1 7.7 8.6 5.4 7.7 1.8 1 1 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) FapA PF03961.13 PIK33513.1 - 7.3 5.1 12.4 8.8 4.8 12.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Filament PF00038.21 PIK33514.1 - 4.4e-06 26.5 43.7 1.9e-05 24.4 43.6 1.8 1 1 0 1 1 1 1 Intermediate filament protein WXG100 PF06013.12 PIK33514.1 - 0.0028 17.9 5.6 0.0028 17.9 5.6 3.7 1 1 2 3 3 3 1 Proteins of 100 residues with WXG Tup_N PF08581.10 PIK33514.1 - 0.0068 16.7 2.7 0.0068 16.7 2.7 4.5 2 1 3 5 5 5 2 Tup N-terminal Apolipoprotein PF01442.18 PIK33514.1 - 0.031 14.1 39.5 0.66 9.8 22.5 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF5595 PF18077.1 PIK33514.1 - 0.034 14.2 6.1 0.034 14.2 6.1 4.4 2 1 3 5 5 5 0 Domain of unknown function (DUF5595) FAM184 PF15665.5 PIK33514.1 - 0.11 12.3 47.2 0.29 10.9 24.4 2.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF883 PF05957.13 PIK33514.1 - 0.26 11.9 26.9 1.3 9.7 2.8 3.2 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.10 PIK33514.1 - 0.65 10.2 35.8 0.85 9.8 3.6 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 PIK33514.1 - 1 9.4 14.7 65 3.6 14.7 2.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF812 PF05667.11 PIK33514.1 - 1.2 8.0 45.3 1.6 7.5 45.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF948 PF06103.11 PIK33514.1 - 1.2 9.5 18.7 0.093 13.0 6.5 3.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) HMMR_N PF15905.5 PIK33514.1 - 1.3 8.5 53.0 0.053 13.0 26.3 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF3584 PF12128.8 PIK33514.1 - 1.3 6.4 46.1 1.6 6.2 18.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) OmpH PF03938.14 PIK33514.1 - 2.1 8.7 52.3 30 5.0 18.5 3.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 PIK33514.1 - 2.1 7.6 38.4 3.4 6.9 35.3 2.0 1 1 1 2 2 2 0 FAM76 protein Pox_A_type_inc PF04508.12 PIK33514.1 - 4.1 7.4 8.2 3.5 7.6 0.8 4.2 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat HIP1_clath_bdg PF16515.5 PIK33514.1 - 4.5 7.9 49.4 0.21 12.2 9.6 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Muted PF14942.6 PIK33514.1 - 7.2 6.9 44.5 14 6.0 20.6 2.3 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Apolipoprotein PF01442.18 PIK33515.1 - 0.036 13.9 54.6 0.1 12.5 21.7 2.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Filament PF00038.21 PIK33515.1 - 0.085 12.4 49.3 1.9 8.0 31.6 2.9 1 1 1 2 2 2 0 Intermediate filament protein Baculo_PEP_C PF04513.12 PIK33515.1 - 0.1 12.6 16.2 0.085 12.9 0.4 3.6 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 PIK33515.1 - 0.63 8.9 57.1 1.6 7.5 24.5 3.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 PIK33515.1 - 1.3 9.1 29.3 0.12 12.4 5.5 3.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3080 PF11279.8 PIK33515.1 - 1.3 8.1 25.4 0.1 11.8 13.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3080) DUF2388 PF09498.10 PIK33515.1 - 2.8 8.0 10.3 3.7 7.6 0.9 3.5 3 2 1 4 4 4 0 Protein of unknown function (DUF2388) GAS PF13851.6 PIK33515.1 - 3.9 6.8 55.0 2.1 7.6 22.6 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding GRIP PF01465.20 PIK33516.1 - 0.00034 20.4 0.1 0.00069 19.5 0.1 1.6 1 0 0 1 1 1 1 GRIP domain DUF3584 PF12128.8 PIK33516.1 - 0.052 11.1 22.2 0.079 10.5 22.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ER PF01133.17 PIK33516.1 - 0.085 12.9 2.9 0.1 12.6 0.3 2.3 2 1 0 2 2 2 0 Enhancer of rudimentary Exonuc_VII_L PF02601.15 PIK33516.1 - 0.096 12.2 19.3 0.3 10.6 19.3 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit FAM184 PF15665.5 PIK33516.1 - 0.12 12.1 35.6 0.012 15.4 30.1 2.1 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B Baculo_PEP_C PF04513.12 PIK33516.1 - 0.23 11.5 8.7 44 4.1 8.7 2.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.11 PIK33516.1 - 0.25 10.6 25.0 0.18 11.1 22.7 1.7 1 1 0 1 1 1 0 SF-assemblin/beta giardin Apolipoprotein PF01442.18 PIK33516.1 - 0.28 11.0 28.4 0.55 10.1 21.5 3.3 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain Phage_Mu_Gam PF07352.12 PIK33516.1 - 1.2 9.0 29.0 0.15 12.0 3.1 4.3 2 2 1 4 4 4 0 Bacteriophage Mu Gam like protein Phasin PF05597.11 PIK33516.1 - 2.5 8.1 17.0 0.4 10.7 9.8 2.8 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4407 PF14362.6 PIK33516.1 - 2.6 7.3 22.3 26 4.1 22.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ZnuA PF01297.17 PIK33516.1 - 3.8 6.9 8.4 1.8 7.9 5.4 2.0 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic APC_u14 PF16635.5 PIK33516.1 - 5.6 7.6 8.9 0.3 11.6 0.8 2.7 2 1 0 3 3 3 0 Unstructured region on APC between SAMP and APC_crr OmpH PF03938.14 PIK33516.1 - 8.5 6.7 35.5 4 7.8 5.7 3.3 1 1 3 4 4 4 0 Outer membrane protein (OmpH-like) ApoO PF09769.9 PIK33516.1 - 8.7 6.3 6.7 3.1 7.8 0.8 2.9 1 1 2 3 3 3 0 Apolipoprotein O GvpL_GvpF PF06386.11 PIK33516.1 - 9.8 6.0 16.4 0.64 9.9 6.4 2.4 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF p450 PF00067.22 PIK33517.1 - 3.5e-118 395.3 0.0 4.3e-118 395.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RVT_2 PF07727.14 PIK33519.1 - 4.2e-53 180.5 0.0 5.6e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PseudoU_synth_2 PF00849.22 PIK33520.1 - 1.8e-10 41.1 0.0 5.4e-10 39.6 0.0 1.8 2 1 0 2 2 2 1 RNA pseudouridylate synthase V-set PF07686.17 PIK33522.1 - 7.2e-09 35.8 0.4 0.0025 18.0 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK33522.1 - 3e-06 27.7 1.1 0.3 11.7 0.0 4.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK33522.1 - 3.8e-06 27.0 0.2 0.037 14.2 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK33522.1 - 0.004 17.4 0.3 1.2 9.5 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin domain RIFIN PF02009.16 PIK33522.1 - 0.0099 15.8 1.1 0.019 14.9 1.1 1.4 1 0 0 1 1 1 1 Rifin Saf_2TM PF18303.1 PIK33522.1 - 0.022 14.4 0.3 0.048 13.2 0.3 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF2207 PF09972.9 PIK33522.1 - 0.029 13.2 0.0 0.046 12.5 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mating_N PF12731.7 PIK33522.1 - 0.041 14.0 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Mating-type protein beta 1 DUF3377 PF11857.8 PIK33522.1 - 0.067 13.1 0.9 0.18 11.7 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) I-set PF07679.16 PIK33522.1 - 0.16 12.0 0.2 14 5.9 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin I-set domain Arm PF00514.23 PIK33523.1 - 3.9e-88 287.1 20.2 6.4e-13 48.3 0.0 8.5 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 PIK33523.1 - 2.4e-22 78.2 1.2 4.4e-21 74.2 0.8 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 PIK33523.1 - 5.1e-22 78.0 4.9 1.6e-06 28.5 0.1 6.1 3 2 4 7 7 7 4 HEAT-like repeat IBB PF01749.20 PIK33523.1 - 6.7e-22 77.7 4.4 2.2e-21 76.1 3.3 2.4 2 0 0 2 2 2 1 Importin beta binding domain HEAT_2 PF13646.6 PIK33523.1 - 3.1e-20 72.3 0.2 2.7e-05 24.5 0.0 5.6 2 1 4 6 6 6 5 HEAT repeats HEAT PF02985.22 PIK33523.1 - 4.1e-18 63.9 9.1 0.0019 18.3 0.0 7.7 8 0 0 8 8 7 3 HEAT repeat Arm_2 PF04826.13 PIK33523.1 - 6.6e-06 25.8 0.1 0.018 14.5 0.1 3.2 2 1 0 2 2 2 2 Armadillo-like V-ATPase_H_C PF11698.8 PIK33523.1 - 0.00016 21.8 0.1 0.22 11.6 0.0 4.1 3 2 1 4 4 4 2 V-ATPase subunit H Adaptin_N PF01602.20 PIK33523.1 - 0.00019 20.2 0.2 0.0053 15.4 0.0 2.8 1 1 1 2 2 2 1 Adaptin N terminal region NopRA1 PF16201.5 PIK33523.1 - 0.00029 20.5 0.0 15 5.1 0.0 4.9 2 2 3 5 5 5 0 Nucleolar pre-ribosomal-associated protein 1 HEAT_PBS PF03130.16 PIK33523.1 - 0.001 19.5 0.2 3.4 8.6 0.0 4.5 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat CTNNBL PF08216.11 PIK33523.1 - 0.0012 19.0 0.2 8.9 6.5 0.0 4.8 5 0 0 5 5 5 1 Catenin-beta-like, Arm-motif containing nuclear SEN1_N PF12726.7 PIK33523.1 - 0.0055 15.0 0.2 0.14 10.3 0.0 2.4 3 0 0 3 3 3 1 SEN1 N terminal RICTOR_V PF14668.6 PIK33523.1 - 0.011 16.0 6.5 4.5 7.6 0.1 4.8 4 2 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 PIK33523.1 - 0.026 14.6 0.1 4.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.8 PIK33523.1 - 0.073 12.6 1.5 0.78 9.3 0.3 2.7 2 2 1 3 3 3 0 CLASP N terminal DUF3361 PF11841.8 PIK33523.1 - 0.12 12.3 3.7 4.7 7.1 0.2 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF3361) Cid2 PF09774.9 PIK33524.1 - 8.4e-06 26.3 0.3 8.7e-06 26.3 0.3 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 CRR7 PF12095.8 PIK33524.1 - 0.059 13.8 0.5 0.071 13.6 0.5 1.1 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 MRP-S31 PF15433.6 PIK33525.1 - 1.1e-73 248.7 3.7 1.4e-73 248.4 3.7 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 EF-hand_4 PF12763.7 PIK33527.1 - 3.8e-13 49.3 0.1 1e-12 47.9 0.0 1.6 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 PIK33527.1 - 0.0016 17.8 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK33527.1 - 0.022 14.7 0.1 0.056 13.4 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 PIK33527.1 - 0.034 13.6 0.1 0.083 12.4 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 PIK33527.1 - 0.15 12.6 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_4 PF12763.7 PIK33528.1 - 1.2e-10 41.2 0.0 2.9e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 PIK33528.1 - 3.6e-05 23.0 0.1 8.7e-05 21.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 PIK33528.1 - 0.012 15.5 0.1 0.03 14.2 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK33528.1 - 0.016 15.1 0.0 0.041 13.8 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 PIK33528.1 - 0.03 13.8 0.1 0.11 12.0 0.1 1.9 1 0 0 1 1 1 0 EF hand Exonuc_VII_L PF02601.15 PIK33528.1 - 3.9 7.0 14.0 6.1 6.3 14.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hid1 PF12722.7 PIK33528.1 - 9.9 4.1 15.0 13 3.8 15.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein EphA2_TM PF14575.6 PIK33529.1 - 0.0021 18.9 0.6 0.59 11.0 0.1 3.0 2 1 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain RSN1_TM PF13967.6 PIK33529.1 - 0.0076 16.0 0.7 0.1 12.4 0.0 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport Shisa PF13908.6 PIK33529.1 - 0.012 15.9 0.0 4.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator ETRAMP PF09716.10 PIK33529.1 - 0.043 13.9 0.0 0.22 11.6 0.0 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4834 PF16118.5 PIK33529.1 - 0.25 12.4 8.9 5.8 7.9 0.0 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) FixH PF05751.11 PIK33529.1 - 0.32 11.0 3.9 2.2 8.3 0.7 2.2 2 0 0 2 2 2 0 FixH Connexin PF00029.19 PIK33529.1 - 0.56 9.9 4.4 8.1 6.1 4.7 2.4 1 1 1 2 2 2 0 Connexin Orf78 PF06024.12 PIK33529.1 - 0.84 10.0 19.8 3.3 8.1 14.6 3.3 2 1 0 2 2 2 0 Orf78 (ac78) PNISR PF15996.5 PIK33529.1 - 0.9 9.8 8.7 1.2 9.4 8.7 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4736 PF15883.5 PIK33529.1 - 1.9 8.2 6.6 0.91 9.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) 7tm_1 PF00001.21 PIK33530.1 - 2.4e-22 79.5 8.9 2.4e-22 79.5 8.9 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK33530.1 - 0.0011 18.4 6.3 0.0014 18.0 6.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF5056 PF16479.5 PIK33530.1 - 0.035 14.3 2.8 0.035 14.3 2.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5056) TSGP1 PF07771.11 PIK33531.1 - 0.052 13.7 0.4 0.052 13.7 0.4 2.1 2 0 0 2 2 2 0 Tick salivary peptide group 1 EloA-BP1 PF15870.5 PIK33532.1 - 1.2e-53 181.8 0.2 1.2e-53 181.8 0.2 6.1 6 2 1 7 7 7 1 ElonginA binding-protein 1 RNase_T PF00929.24 PIK33532.1 - 9e-06 26.3 0.1 8.1e-05 23.2 0.1 2.5 1 1 0 1 1 1 1 Exonuclease Tctex-1 PF03645.13 PIK33533.1 - 2e-23 82.6 0.1 2.7e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 Tctex-1 family CEBP_ZZ PF16366.5 PIK33534.1 - 0.11 12.7 0.1 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Fibrinogen_C PF00147.18 PIK33535.1 - 5.7e-35 121.1 0.1 6.6e-35 120.9 0.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ion_trans PF00520.31 PIK33536.1 - 3.4e-44 150.9 51.4 1.3e-29 103.2 16.1 2.2 2 0 0 2 2 2 2 Ion transport protein Wzz PF02706.15 PIK33536.1 - 0.81 10.0 0.0 0.81 10.0 0.0 3.1 3 0 0 3 3 3 0 Chain length determinant protein OppC_N PF12911.7 PIK33536.1 - 9.1 6.4 17.4 4.8 7.2 0.2 5.3 5 0 0 5 5 5 0 N-terminal TM domain of oligopeptide transport permease C E1_DerP2_DerF2 PF02221.15 PIK33537.1 - 4.5e-20 72.4 4.6 6.3e-20 72.0 4.6 1.1 1 0 0 1 1 1 1 ML domain PDDEXK_10 PF07788.11 PIK33537.1 - 0.0099 15.8 0.7 0.018 15.0 0.7 1.4 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Menin PF05053.13 PIK33538.1 - 2.8e-39 135.1 0.0 3.2e-39 134.9 0.0 1.0 1 0 0 1 1 1 1 Menin DUF499 PF04465.12 PIK33538.1 - 0.0029 15.5 0.0 0.0034 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF499) SPX PF03105.19 PIK33539.1 - 1.5 8.7 9.0 2.2 8.1 9.0 1.3 1 0 0 1 1 1 0 SPX domain EGF_CA PF07645.15 PIK33540.1 - 1.3e-07 31.7 7.1 1.3e-07 31.7 7.1 2.1 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK33540.1 - 5.4e-07 29.8 8.2 1.5e-06 28.3 8.2 1.9 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Lectin_C PF00059.21 PIK33540.1 - 1.7e-05 25.5 1.5 5.1e-05 24.0 1.5 1.8 1 1 0 1 1 1 1 Lectin C-type domain EGF PF00008.27 PIK33540.1 - 0.00052 20.3 9.2 0.001 19.3 8.0 2.2 1 1 0 1 1 1 1 EGF-like domain cEGF PF12662.7 PIK33540.1 - 0.00096 19.0 5.4 0.0021 18.0 1.7 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK33540.1 - 0.057 13.6 3.8 0.057 13.6 3.8 1.9 2 0 0 2 2 2 0 EGF domain DHQS PF01959.16 PIK33542.1 - 0.0056 15.6 0.5 0.0065 15.4 0.5 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase II DUF4520 PF15016.6 PIK33542.1 - 0.07 13.2 7.1 0.21 11.7 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4520) RCC1 PF00415.18 PIK33543.1 - 1.9e-64 214.1 20.5 7.6e-12 45.7 0.0 8.3 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK33543.1 - 1.6e-54 180.7 42.9 2.9e-12 46.0 1.6 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 PIK33543.1 - 0.012 15.4 0.0 0.91 9.4 0.0 3.1 3 0 0 3 3 3 0 Peptidase family C25, C terminal ig-like domain Hira PF07569.11 PIK33543.1 - 0.47 10.1 2.2 13 5.4 0.0 3.3 4 0 0 4 4 4 0 TUP1-like enhancer of split cNMP_binding PF00027.29 PIK33545.1 - 1.7e-06 28.0 0.0 0.00011 22.1 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain IQ PF00612.27 PIK33547.1 - 1.5e-128 406.7 438.3 3.1e-05 23.4 0.2 63.2 64 0 0 64 64 64 56 IQ calmodulin-binding motif QslA_E PF18226.1 PIK33547.1 - 3.1 7.8 17.8 35 4.4 0.2 6.4 6 0 0 6 6 6 0 LasR-specific antiactivator QslA chain E DUF5620 PF18522.1 PIK33547.1 - 8.6 6.8 5.9 1.8e+02 2.5 0.1 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF5620) DUF1985 PF09331.11 PIK33549.1 - 4.7e-21 75.2 0.0 7.3e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1985) LRR_8 PF13855.6 PIK33550.1 - 3.8e-09 36.2 1.3 3.3e-08 33.2 0.5 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK33550.1 - 0.02 15.3 0.7 0.75 10.3 0.5 2.8 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK33550.1 - 0.03 14.3 0.1 0.068 13.1 0.1 1.5 1 1 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) CK1gamma_C PF12605.8 PIK33551.1 - 1.2e-12 48.9 0.0 1.2e-12 48.9 0.0 1.2 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal DNA_methylase PF00145.17 PIK33552.1 - 1e-15 58.0 0.0 1.1e-15 57.8 0.0 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Spectrin PF00435.21 PIK33553.1 - 1.2e-15 57.8 22.7 9.1e-12 45.4 2.8 3.1 3 0 0 3 3 3 2 Spectrin repeat HBM PF16591.5 PIK33553.1 - 0.088 12.2 3.1 0.34 10.3 1.1 2.2 1 1 2 3 3 3 0 Helical bimodular sensor domain PI_PP_I PF18363.1 PIK33553.1 - 0.11 12.7 4.9 2.5 8.4 0.4 2.9 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain BAH PF01426.18 PIK33553.1 - 0.13 12.2 0.7 0.25 11.2 0.7 1.5 1 0 0 1 1 1 0 BAH domain BLOC1_2 PF10046.9 PIK33553.1 - 0.19 12.1 0.1 0.19 12.1 0.1 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4549 PF15082.6 PIK33553.1 - 0.63 9.8 8.1 2.9 7.7 0.0 3.6 2 1 1 4 4 4 0 Domain of unknown function (DUF4549) FliT PF05400.13 PIK33553.1 - 0.69 10.8 7.7 0.26 12.1 3.5 2.3 2 1 0 2 2 2 0 Flagellar protein FliT Laminin_II PF06009.12 PIK33553.1 - 1.1 9.3 5.5 1.4 8.9 0.1 3.0 2 1 2 4 4 4 0 Laminin Domain II Cytochrom_B562 PF07361.11 PIK33553.1 - 1.4 9.6 6.0 0.77 10.5 2.8 2.3 1 1 0 1 1 1 0 Cytochrome b562 DUF1664 PF07889.12 PIK33553.1 - 5.5 7.0 10.0 3.1 7.9 2.8 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 PIK33553.1 - 7 6.9 15.0 2.3 8.5 0.7 3.2 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spectrin PF00435.21 PIK33554.1 - 1.6e-09 38.2 26.0 7.7e-06 26.3 12.0 4.6 3 2 0 3 3 3 2 Spectrin repeat Dynactin_p22 PF07426.11 PIK33554.1 - 0.0026 17.6 2.9 0.0026 17.6 2.9 1.8 2 0 0 2 2 2 1 Dynactin subunit p22 Taxilin PF09728.9 PIK33554.1 - 0.0093 15.2 7.0 0.0072 15.5 5.1 1.7 1 1 0 1 1 1 1 Myosin-like coiled-coil protein IL11 PF07400.11 PIK33554.1 - 0.016 14.9 2.3 0.023 14.3 1.1 1.9 2 1 0 2 2 2 0 Interleukin 11 BLOC1_2 PF10046.9 PIK33554.1 - 0.11 12.8 11.9 0.75 10.1 0.1 4.5 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LPP PF04728.13 PIK33554.1 - 0.15 12.5 4.9 0.46 10.9 0.5 3.5 3 1 0 3 3 3 0 Lipoprotein leucine-zipper TolA_bind_tri PF16331.5 PIK33554.1 - 0.19 11.9 2.6 1.6 8.9 0.1 2.9 3 0 0 3 3 3 0 TolA binding protein trimerisation Med2 PF11214.8 PIK33554.1 - 0.19 11.9 4.8 0.21 11.7 0.8 2.8 2 1 0 2 2 2 0 Mediator complex subunit 2 DUF4164 PF13747.6 PIK33554.1 - 0.25 11.6 9.1 1.5 9.1 0.6 3.7 3 2 0 3 3 3 0 Domain of unknown function (DUF4164) Sec34 PF04136.15 PIK33554.1 - 0.27 11.1 5.5 2.1 8.2 0.6 3.0 2 1 1 3 3 3 0 Sec34-like family DegS PF05384.11 PIK33554.1 - 0.56 9.7 5.3 5.2 6.5 0.6 2.8 3 0 0 3 3 3 0 Sensor protein DegS Laminin_II PF06009.12 PIK33554.1 - 0.66 10.0 7.7 0.51 10.3 0.2 2.9 3 1 0 3 3 3 0 Laminin Domain II Seryl_tRNA_N PF02403.22 PIK33554.1 - 1.1 9.5 14.1 1.6 9.0 0.1 3.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain YabA PF06156.13 PIK33554.1 - 1.2 9.8 6.3 9 7.0 0.0 3.2 3 0 0 3 3 3 0 Initiation control protein YabA CREPT PF16566.5 PIK33554.1 - 2 8.6 7.7 1.4 9.1 0.3 3.0 2 2 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF16 PF01519.16 PIK33554.1 - 2.9 8.4 11.9 9 6.9 5.8 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF2959 PF11172.8 PIK33554.1 - 3.3 7.8 9.1 1 9.4 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2959) Tropomyosin_1 PF12718.7 PIK33554.1 - 4 7.6 17.3 5.1 7.2 0.2 3.2 2 1 0 2 2 2 0 Tropomyosin like Mit_KHE1 PF10173.9 PIK33554.1 - 4.8 7.2 12.2 5.2 7.1 4.3 2.9 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related ZapB PF06005.12 PIK33554.1 - 6.6 7.3 17.4 13 6.3 3.1 3.9 4 0 0 4 4 4 0 Cell division protein ZapB EF-hand_2 PF09068.11 PIK33555.1 - 2.5e-41 140.7 1.8 2.5e-41 140.7 1.8 1.7 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.11 PIK33555.1 - 1.3e-22 80.0 0.6 4.4e-22 78.3 0.2 2.2 2 0 0 2 2 2 1 EF-hand ZZ PF00569.17 PIK33555.1 - 2.2e-17 62.6 10.3 4.7e-17 61.5 10.3 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-B_box PF00643.24 PIK33555.1 - 1.4 9.1 13.2 0.64 10.2 9.4 2.4 2 0 0 2 2 2 0 B-box zinc finger Ig_3 PF13927.6 PIK33556.1 - 5.7e-06 26.8 2.4 0.043 14.4 0.4 2.9 2 1 1 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK33556.1 - 0.00056 20.2 0.2 0.0015 18.9 0.1 1.7 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_2 PF13895.6 PIK33556.1 - 0.00087 19.6 0.0 1 9.8 0.0 2.3 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK33556.1 - 0.0016 18.5 0.3 0.29 11.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK33556.1 - 0.0058 16.8 0.2 6.4 7.0 0.1 2.8 2 1 1 3 3 3 2 Immunoglobulin domain Inhibitor_I48 PF10467.9 PIK33556.1 - 0.02 14.7 0.0 0.092 12.6 0.0 1.8 1 1 1 2 2 2 0 Peptidase inhibitor clitocypin C2-set_2 PF08205.12 PIK33556.1 - 0.043 13.9 0.1 0.078 13.1 0.1 1.5 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Sybindin PF04099.12 PIK33557.1 - 0.015 15.2 0.4 0.4 10.6 0.0 2.5 2 0 0 2 2 2 0 Sybindin-like family PI3Ka PF00613.20 PIK33557.1 - 0.04 13.3 0.6 0.12 11.8 0.2 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) NACHT PF05729.12 PIK33558.1 - 3.3e-10 40.1 0.0 1.1e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK33558.1 - 0.027 14.1 0.0 0.074 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK33558.1 - 0.031 14.5 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Meckelin PF09773.9 PIK33560.1 - 1.8e-165 552.4 12.4 2e-165 552.2 12.4 1.0 1 0 0 1 1 1 1 Meckelin (Transmembrane protein 67) zf-C2H2 PF00096.26 PIK33561.1 - 3.4e-10 39.8 37.2 0.00013 22.3 4.1 5.4 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK33561.1 - 2.6e-06 27.6 7.9 0.00067 19.9 0.2 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK33561.1 - 8.8e-06 25.9 1.3 3.3e-05 24.1 1.3 2.0 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-met PF12874.7 PIK33561.1 - 8.1e-05 22.9 15.0 0.00076 19.8 0.6 3.8 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 PIK33561.1 - 0.00012 22.4 30.3 0.00019 21.7 3.1 4.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK33561.1 - 0.00037 21.1 33.1 0.0075 17.0 2.9 5.0 5 0 0 5 5 5 3 C2H2-type zinc finger DUF2225 PF09986.9 PIK33561.1 - 0.28 10.9 2.5 3.6 7.3 0.6 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2HC_2 PF13913.6 PIK33561.1 - 0.35 10.8 4.2 5.4 7.0 0.3 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 PIK33561.1 - 0.42 10.9 16.8 0.39 11.0 5.1 3.2 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 PIK33561.1 - 0.63 10.4 13.8 2.7 8.4 3.5 3.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 PIK33561.1 - 0.91 9.6 14.4 1.7 8.8 1.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 PIK33561.1 - 1.2 9.3 4.5 3.3 7.9 1.8 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 PIK33562.1 - 2.8e-13 49.6 22.0 2.3e-07 30.9 0.1 5.7 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK33562.1 - 7e-11 42.0 25.2 0.0015 18.9 3.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK33562.1 - 8.5e-09 35.5 21.5 0.0046 17.7 1.6 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger DprA_WH PF17782.1 PIK33562.1 - 0.039 14.1 0.2 0.06 13.5 0.2 1.3 1 0 0 1 1 1 0 DprA winged helix domain C1_4 PF07975.12 PIK33562.1 - 0.052 13.8 10.6 1.1 9.5 0.2 3.1 2 1 1 3 3 3 0 TFIIH C1-like domain DM PF00751.18 PIK33562.1 - 0.056 13.4 4.2 0.056 13.4 4.2 3.0 2 1 0 2 2 1 0 DM DNA binding domain CpXC PF14353.6 PIK33562.1 - 0.32 11.0 9.1 0.94 9.5 0.7 2.8 1 1 2 3 3 3 0 CpXC protein zf_UBZ PF18439.1 PIK33562.1 - 0.38 10.4 11.3 1.1 9.0 0.2 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_4 PF13717.6 PIK33562.1 - 0.53 10.2 6.7 2.2 8.3 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain AHH PF14412.6 PIK33562.1 - 0.74 9.9 4.6 0.21 11.6 1.0 1.9 1 1 1 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH zf-HIT PF04438.16 PIK33562.1 - 1.7 8.6 14.2 0.29 11.0 0.5 4.0 4 0 0 4 4 4 0 HIT zinc finger zf-FLZ PF04570.14 PIK33562.1 - 3.2 7.3 7.8 0.13 11.7 1.3 2.2 3 0 0 3 3 3 0 zinc-finger of the FCS-type, C2-C2 zf_C2H2_ZHX PF18387.1 PIK33562.1 - 3.4 7.4 7.5 8.4 6.1 1.0 2.6 2 1 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain FYDLN_acid PF09538.10 PIK33562.1 - 5.3 7.8 8.6 0.44 11.3 1.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2H2_11 PF16622.5 PIK33562.1 - 5.9 6.8 17.7 2 8.2 0.8 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 PIK33562.1 - 8 6.9 14.7 12 6.3 4.8 3.0 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 PIK33563.1 - 2.4e-26 91.0 32.0 1.4e-10 41.1 1.0 5.6 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 PIK33563.1 - 9.1e-20 69.9 38.7 1.3e-05 25.3 3.7 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK33563.1 - 1.1e-15 56.9 35.5 0.00016 22.2 1.9 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK33563.1 - 7e-14 51.7 25.1 0.00056 20.1 1.1 5.0 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK33563.1 - 2.6e-09 37.2 24.4 0.0029 17.9 1.6 4.4 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 PIK33563.1 - 6e-05 23.3 15.2 0.024 14.9 9.6 3.7 2 1 2 4 4 4 2 C2H2-type zinc ribbon zf-C2H2_2 PF12756.7 PIK33563.1 - 0.0027 18.0 18.9 0.31 11.4 0.2 4.5 2 1 3 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 PIK33563.1 - 0.015 15.3 36.1 0.22 11.6 2.0 5.1 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK33563.1 - 0.016 15.9 8.9 2.4 8.9 0.0 3.3 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Elf1 PF05129.13 PIK33563.1 - 0.031 14.3 5.6 0.031 14.3 5.6 3.6 2 1 2 4 4 4 0 Transcription elongation factor Elf1 like RNase_P_pop3 PF08228.11 PIK33563.1 - 0.04 14.0 0.0 0.061 13.4 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit Pop3 Zn-ribbon_8 PF09723.10 PIK33563.1 - 0.05 13.7 14.5 5 7.3 3.7 4.8 4 1 1 5 5 5 0 Zinc ribbon domain C1_4 PF07975.12 PIK33563.1 - 0.099 12.9 19.2 0.51 10.6 3.8 4.4 2 1 3 5 5 5 0 TFIIH C1-like domain zf-Sec23_Sec24 PF04810.15 PIK33563.1 - 0.11 12.5 10.4 5.7 7.1 0.2 4.4 5 0 0 5 5 5 0 Sec23/Sec24 zinc finger C1_1 PF00130.22 PIK33563.1 - 0.12 12.3 18.9 0.058 13.3 2.7 4.2 2 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-AN1 PF01428.16 PIK33563.1 - 0.16 12.2 20.4 5.3 7.3 0.3 5.1 5 0 0 5 5 5 0 AN1-like Zinc finger Spt46 PF17734.1 PIK33563.1 - 0.24 11.2 6.2 0.81 9.5 1.3 2.4 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 zf-HYPF PF07503.12 PIK33563.1 - 0.31 10.9 3.8 1.6 8.6 0.7 3.2 2 1 0 2 2 2 0 HypF finger zinc_ribbon_15 PF17032.5 PIK33563.1 - 0.44 11.3 13.9 0.27 12.0 2.2 3.0 2 1 3 5 5 4 0 zinc-ribbon family PyrI_C PF02748.15 PIK33563.1 - 0.5 10.3 13.2 29 4.7 0.0 4.6 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_UBZ PF18439.1 PIK33563.1 - 0.54 9.9 9.7 12 5.6 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Evr1_Alr PF04777.13 PIK33563.1 - 0.54 10.7 16.7 16 6.0 0.4 4.5 2 1 1 3 3 3 0 Erv1 / Alr family zf-MYST PF17772.1 PIK33563.1 - 1.4 8.6 12.7 2.7 7.7 0.1 3.8 4 1 1 5 5 3 0 MYST family zinc finger domain zf-C2HE PF16278.5 PIK33563.1 - 1.6 9.2 27.4 2.9 8.4 1.9 5.0 3 2 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zinc-ribbons_6 PF07191.12 PIK33563.1 - 2 8.4 16.7 13 5.9 2.1 4.2 2 1 2 4 4 4 0 zinc-ribbons Sprouty PF05210.13 PIK33563.1 - 2.6 8.5 10.1 0.17 12.3 3.0 2.4 3 0 0 3 3 2 0 Sprouty protein (Spry) Prok-RING_1 PF14446.6 PIK33563.1 - 5.3 7.1 15.5 3.3 7.7 0.1 4.3 5 0 0 5 5 4 0 Prokaryotic RING finger family 1 zinc_ribbon_4 PF13717.6 PIK33563.1 - 6.1 6.9 14.9 8 6.5 3.0 4.0 3 1 0 3 3 3 0 zinc-ribbon domain zf-C2H2 PF00096.26 PIK33564.1 - 1.8e-37 125.7 56.8 3.1e-06 27.3 0.2 9.3 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK33564.1 - 4.3e-32 109.1 51.2 3.8e-09 36.6 0.4 9.0 9 1 0 9 9 9 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK33564.1 - 3.7e-26 89.5 55.9 0.0021 18.8 0.8 9.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK33564.1 - 5.3e-13 48.6 55.3 0.00012 22.0 0.1 9.4 9 1 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK33564.1 - 1.7e-09 37.3 32.1 0.0086 15.8 0.0 8.7 9 0 0 9 9 9 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 PIK33564.1 - 1.4e-08 34.9 30.5 0.00021 21.5 1.9 5.2 1 1 5 6 6 6 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 PIK33564.1 - 4.4e-08 33.2 36.0 0.022 15.1 0.2 9.0 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK33564.1 - 2.6e-07 30.8 29.2 0.0049 17.2 1.3 7.8 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK33564.1 - 0.004 17.9 27.3 1.3 9.9 1.0 5.0 1 1 4 5 5 5 2 zinc-ribbon family zf_UBZ PF18439.1 PIK33564.1 - 0.0046 16.5 34.5 1.3 8.7 0.1 8.1 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger ROS_MUCR PF05443.11 PIK33564.1 - 0.0088 16.1 5.5 0.44 10.6 1.5 3.3 2 1 0 2 2 2 1 ROS/MUCR transcriptional regulator protein zf-C2HE PF16278.5 PIK33564.1 - 0.019 15.4 1.7 0.019 15.4 1.7 8.1 2 2 6 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger TerY_C PF15616.6 PIK33564.1 - 0.019 15.1 2.6 0.26 11.4 0.1 2.7 2 1 0 2 2 2 0 TerY-C metal binding domain zf-C2H2_9 PF16293.5 PIK33564.1 - 0.019 14.8 14.3 0.49 10.3 0.1 5.7 5 1 1 6 6 6 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 PIK33564.1 - 0.022 15.1 36.5 2 8.8 0.5 6.5 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 PIK33564.1 - 0.034 13.9 0.1 0.12 12.1 0.1 9.7 11 0 0 11 11 10 0 C2H2-type zinc-finger domain zf-LYAR PF08790.11 PIK33564.1 - 0.035 14.0 28.9 0.21 11.5 0.0 8.1 9 0 0 9 9 8 0 LYAR-type C2HC zinc finger zf_C2H2_10 PF18414.1 PIK33564.1 - 0.036 13.6 1.5 0.23 11.0 0.0 3.1 2 0 0 2 2 2 0 C2H2 type zinc-finger HypA PF01155.19 PIK33564.1 - 0.036 14.1 25.3 0.29 11.2 2.7 4.5 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 PIK33564.1 - 0.036 14.2 2.9 0.036 14.2 2.9 6.5 4 1 3 7 7 7 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 PIK33564.1 - 0.071 13.0 0.7 0.071 13.0 0.7 4.7 4 0 0 4 4 4 0 zinc-finger of a C2HC-type C1_4 PF07975.12 PIK33564.1 - 0.1 12.9 33.4 0.34 11.2 4.4 6.0 2 2 3 5 5 5 0 TFIIH C1-like domain Spt46 PF17734.1 PIK33564.1 - 0.1 12.4 10.7 3 7.6 0.1 3.9 3 1 1 4 4 4 0 Spermatogenesis-associated protein 46 Elf1 PF05129.13 PIK33564.1 - 0.48 10.5 32.8 0.18 11.9 1.7 5.4 2 2 4 6 6 6 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 PIK33564.1 - 1.4 9.2 40.1 5.9 7.1 0.3 8.0 8 0 0 8 8 8 0 AN1-like Zinc finger Trm112p PF03966.16 PIK33564.1 - 2.5 8.8 15.4 2.6 8.7 2.7 5.4 3 2 1 4 4 3 0 Trm112p-like protein ADK_lid PF05191.14 PIK33564.1 - 4.2 7.4 21.7 6.8 6.8 0.2 5.4 5 1 0 5 5 4 0 Adenylate kinase, active site lid DUF1279 PF06916.13 PIK33565.1 - 5.6e-25 87.7 0.2 1.1e-24 86.8 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Pkinase PF00069.25 PIK33566.1 - 4.2e-75 252.5 0.0 4.7e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK33566.1 - 2.3e-44 151.6 0.0 2.9e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK33566.1 - 1.5e-05 24.5 0.0 0.00037 19.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.9 PIK33566.1 - 0.0011 18.5 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 PIK33566.1 - 0.036 14.0 0.5 8.4 6.2 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family LRRC37AB_C PF14914.6 PIK33567.1 - 0.94 9.4 2.9 21 5.0 1.1 2.1 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain TPR_2 PF07719.17 PIK33568.1 - 2.3e-16 58.5 11.3 0.06 13.5 0.0 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 PIK33568.1 - 1.5e-15 56.3 9.8 0.22 12.0 0.1 9.2 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK33568.1 - 1.8e-15 56.0 6.7 0.00078 19.2 0.2 6.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK33568.1 - 4.2e-15 56.0 2.3 0.00045 20.7 0.0 6.0 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 PIK33568.1 - 1.2e-14 54.4 4.3 0.00031 21.0 0.1 5.1 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK33568.1 - 6.8e-14 51.4 1.1 0.34 11.8 0.0 7.8 3 2 5 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK33568.1 - 8.6e-13 48.7 0.3 0.009 16.6 0.0 6.7 4 2 2 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK33568.1 - 3.1e-12 45.7 5.5 0.00056 19.9 0.2 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK33568.1 - 7.9e-11 41.5 3.4 0.33 10.9 0.0 6.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK33568.1 - 3e-09 36.4 11.6 7.3e-05 22.4 0.0 6.5 6 2 0 6 6 6 2 TPR repeat TPR_6 PF13174.6 PIK33568.1 - 8.3e-05 23.0 6.2 0.29 11.9 0.0 5.9 7 0 0 7 7 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK33568.1 - 0.0004 20.6 11.4 0.015 15.5 3.5 4.4 4 2 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK33568.1 - 0.00044 20.1 11.8 0.48 10.6 0.0 6.4 7 1 0 7 7 6 1 Tetratricopeptide repeat SNAP PF14938.6 PIK33568.1 - 0.0016 17.9 0.6 0.0016 17.9 0.6 2.6 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP PMEI PF04043.15 PIK33568.1 - 0.0021 18.4 1.8 0.0073 16.7 0.7 2.4 3 0 0 3 3 3 1 Plant invertase/pectin methylesterase inhibitor Herpes_IE1 PF07340.11 PIK33568.1 - 0.033 13.1 0.1 0.053 12.4 0.1 1.3 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein YfiO PF13525.6 PIK33568.1 - 0.59 9.8 9.3 0.18 11.5 4.1 2.6 2 1 0 2 2 2 0 Outer membrane lipoprotein TPR_1 PF00515.28 PIK33569.1 - 2.2e-18 65.2 13.5 3.3e-06 26.7 0.8 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK33569.1 - 5.3e-14 51.2 8.5 3.5e-05 23.7 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK33569.1 - 7e-14 50.7 12.5 0.00013 21.8 0.4 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK33569.1 - 1.4e-09 38.0 0.9 0.053 14.4 0.1 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK33569.1 - 1.1e-08 35.5 3.9 3e-05 24.5 0.2 4.4 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK33569.1 - 1.6e-07 30.9 2.7 0.28 10.9 0.2 4.4 4 0 0 4 4 4 3 TPR repeat TPR_16 PF13432.6 PIK33569.1 - 6e-07 30.0 2.5 0.0024 18.5 0.1 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK33569.1 - 6.9e-07 29.2 6.3 5.6 7.6 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK33569.1 - 2.4e-06 27.8 7.1 0.0069 16.7 1.0 3.0 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK33569.1 - 4.8e-06 26.2 4.1 0.37 10.9 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK33569.1 - 2.3e-05 24.7 9.7 0.76 10.5 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK33569.1 - 5.1e-05 23.4 4.6 0.0054 16.9 0.7 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 PIK33569.1 - 0.00092 19.0 1.2 0.68 9.9 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat HPS3_Mid PF14762.6 PIK33569.1 - 0.047 12.4 1.2 3.7 6.2 0.1 2.2 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3, middle region Sel1 PF08238.12 PIK33569.1 - 0.068 13.9 8.7 21 6.0 0.5 4.9 5 1 0 5 5 5 0 Sel1 repeat TPR_9 PF13371.6 PIK33569.1 - 0.07 13.3 0.2 0.42 10.8 0.0 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK33569.1 - 0.086 12.9 10.9 2.8 8.1 4.6 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 PIK33569.1 - 0.78 9.8 9.1 1.8 8.7 0.3 3.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 PIK33569.1 - 1.7 8.8 6.2 8.1 6.6 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Cas_Csd1 PF09709.10 PIK33570.1 - 0.04 12.6 0.0 0.053 12.2 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csd1) RT_RNaseH PF17917.1 PIK33572.1 - 6.7e-34 116.3 0.0 1.2e-33 115.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK33572.1 - 1.1e-32 112.0 0.0 2.4e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33572.1 - 1.6e-23 83.4 0.0 2.8e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK33572.1 - 1.5e-12 47.4 0.4 3.4e-12 46.3 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-C2H2_10 PF16588.5 PIK33572.1 - 3e-05 23.6 3.0 5.8e-05 22.7 3.0 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger SCAN PF02023.17 PIK33572.1 - 0.00012 21.8 0.1 0.00058 19.6 0.0 2.2 2 0 0 2 2 2 1 SCAN domain zf-H2C2 PF09337.10 PIK33572.1 - 0.11 12.8 0.1 0.5 10.6 0.1 2.1 2 0 0 2 2 2 0 H2C2 zinc finger Fibrinogen_C PF00147.18 PIK33573.1 - 1.4e-24 87.2 1.1 1.5e-24 87.1 1.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4781 PF16013.5 PIK33573.1 - 0.12 11.1 0.1 0.14 10.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) PMSR PF01625.21 PIK33574.1 - 3.9e-28 98.5 2.1 4.9e-28 98.2 2.1 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Urotensin_II PF02083.15 PIK33574.1 - 5.9 6.8 6.7 15 5.5 0.6 2.5 2 0 0 2 2 2 0 Urotensin II CATSPERG PF15064.6 PIK33575.1 - 0.01 13.7 0.0 0.013 13.4 0.0 1.2 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit gamma CATSPERG PF15064.6 PIK33576.1 - 1.3e-36 125.9 0.0 1.7e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit gamma Pentapeptide PF00805.22 PIK33577.1 - 6.6e-16 57.6 9.2 1.1e-08 34.5 0.8 2.8 1 1 0 2 2 2 2 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 PIK33577.1 - 9.5e-13 48.3 0.0 1.9e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.6 PIK33577.1 - 4.1e-08 33.3 1.0 0.01 16.0 0.1 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) KHA PF11834.8 PIK33577.1 - 4.7e-08 33.0 0.0 8.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Pentapeptide_3 PF13576.6 PIK33577.1 - 0.00013 22.0 0.1 0.077 13.2 0.1 2.8 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) BTB_3 PF16017.5 PIK33577.1 - 0.00036 20.6 0.0 0.0007 19.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK33577.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain TRP_2 PF08344.11 PIK33579.1 - 2.9e-12 46.6 0.0 7.3e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 PIK33579.1 - 6.1e-09 35.5 17.1 3.5e-08 33.0 17.1 2.2 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK33579.1 - 0.11 11.2 8.5 0.028 13.1 1.1 2.6 2 0 0 2 2 2 0 Polycystin cation channel 7tm_1 PF00001.21 PIK33580.1 - 3e-36 125.1 17.9 4.1e-36 124.7 17.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK33580.1 - 9.5e-13 48.4 12.7 9.5e-13 48.4 12.7 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK33580.1 - 2e-05 24.1 9.3 2e-05 24.1 9.3 1.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK33580.1 - 0.00013 21.4 13.3 0.00021 20.8 13.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv CENP-C_C PF11699.8 PIK33580.1 - 0.037 14.2 1.0 0.067 13.4 0.2 1.8 2 0 0 2 2 2 0 Mif2/CENP-C like Git3 PF11710.8 PIK33580.1 - 0.12 12.1 15.2 0.0087 15.9 10.5 1.5 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 eIF3g PF12353.8 PIK33581.1 - 0.024 15.0 0.8 0.024 15.0 0.8 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G zf-CCCH_7 PF18586.1 PIK33581.1 - 0.03 14.7 2.2 0.049 14.0 0.8 2.0 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 RT_RNaseH_2 PF17919.1 PIK33582.1 - 4.1e-18 65.3 0.0 8.4e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK33582.1 - 1.2e-17 64.2 0.0 2.9e-17 63.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK33582.1 - 2.9e-08 34.0 0.0 6.3e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK33582.1 - 0.005 16.6 0.1 0.017 14.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK33582.1 - 0.046 13.9 0.0 0.093 13.0 0.0 1.6 1 0 0 1 1 1 0 DDE domain HECT PF00632.25 PIK33583.1 - 2.2e-10 40.6 0.0 2.7e-05 23.8 0.0 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) DUF4219 PF13961.6 PIK33583.1 - 0.12 12.1 0.1 0.28 10.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) DUF4371 PF14291.6 PIK33584.1 - 7.3e-24 84.7 0.0 8.3e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) rve PF00665.26 PIK33585.1 - 0.068 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Tex_YqgF PF16921.5 PIK33586.1 - 0.14 12.6 0.2 0.19 12.2 0.2 1.2 1 0 0 1 1 1 0 Tex protein YqgF-like domain HS1_rep PF02218.15 PIK33588.1 - 3.9e-117 382.3 70.5 3.6e-20 72.0 7.2 6.2 6 0 0 6 6 6 6 Repeat in HS1/Cortactin TMEM210 PF15195.6 PIK33588.1 - 9.2e-07 29.3 6.5 30 5.1 0.0 6.0 1 1 4 6 6 6 4 TMEM210 family PPO1_DWL PF12142.8 PIK33588.1 - 0.16 11.8 10.5 70 3.3 0.1 5.4 6 0 0 6 6 6 0 Polyphenol oxidase middle domain OMP_b-brl PF13505.6 PIK33588.1 - 9.6 6.3 19.8 8.1e+02 0.0 19.7 3.0 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain CUE PF02845.16 PIK33589.1 - 1e-14 53.9 0.1 1.7e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 CUE domain C2 PF00168.30 PIK33589.1 - 1.6e-08 34.8 0.0 2.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain CDC37_M PF08565.11 PIK33590.1 - 5.8e-25 87.5 1.2 1.2e-24 86.4 1.2 1.6 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain Anoctamin PF04547.12 PIK33590.1 - 0.19 10.5 3.0 0.15 10.9 1.7 1.5 1 1 1 2 2 2 0 Calcium-activated chloride channel SASP PF00269.20 PIK33590.1 - 0.49 10.5 2.0 1 9.4 2.0 1.5 1 0 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type EMC3_TMCO1 PF01956.16 PIK33590.1 - 0.65 9.7 6.0 0.04 13.7 0.6 1.7 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Tmemb_9 PF05434.11 PIK33590.1 - 2.1 8.2 5.2 1.1 9.2 1.7 2.1 2 0 0 2 2 2 0 TMEM9 DUF3523 PF12037.8 PIK33590.1 - 3.7 6.8 15.1 0.086 12.2 5.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3523) DUF4446 PF14584.6 PIK33590.1 - 8.8 6.3 7.6 1.9 8.4 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) RUN PF02759.19 PIK33591.1 - 5e-25 88.0 2.8 7e-13 48.7 0.6 2.5 2 0 0 2 2 2 2 RUN domain PLAT PF01477.23 PIK33591.1 - 1.4e-11 45.0 0.0 2.6e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Peptidase_M13_N PF05649.13 PIK33592.1 - 2.2e-23 83.6 0.2 4.6e-23 82.5 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK33592.1 - 3e-13 49.8 0.9 1.1e-12 48.1 0.3 2.1 2 1 0 2 2 2 1 Peptidase family M13 DUF4320 PF14208.6 PIK33592.1 - 0.22 11.6 1.6 5.1 7.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) RT_RNaseH_2 PF17919.1 PIK33593.1 - 2.5e-33 114.1 0.0 5.4e-33 113.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33593.1 - 3.4e-32 110.8 0.0 7.9e-32 109.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33593.1 - 5e-31 107.9 0.1 1e-30 107.0 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK33593.1 - 4.1e-23 81.2 0.1 1.3e-22 79.7 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33593.1 - 0.00067 19.8 0.1 0.0028 17.8 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger rve PF00665.26 PIK33593.1 - 0.0011 19.2 0.0 0.0037 17.5 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.14 PIK33593.1 - 0.016 15.3 0.0 0.034 14.3 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Chromo PF00385.24 PIK33593.1 - 0.027 14.4 0.3 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 PIK33594.1 - 7.6e-42 143.3 0.1 1.4e-41 142.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK33595.1 - 7.1e-23 81.3 9.6 9.1e-23 80.9 9.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ATP-gua_PtransN PF02807.15 PIK33596.1 - 7.4e-28 96.7 0.0 1.6e-27 95.6 0.0 1.6 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, N-terminal domain CBFD_NFYB_HMF PF00808.23 PIK33597.1 - 1.5e-19 70.0 1.0 2.6e-19 69.3 1.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK33597.1 - 3.1e-06 27.6 0.4 3.1e-06 27.6 0.4 2.5 2 1 1 3 3 3 1 Core histone H2A/H2B/H3/H4 Myc_N PF01056.18 PIK33597.1 - 0.0071 16.3 7.5 0.0088 16.0 7.5 1.1 1 0 0 1 1 1 1 Myc amino-terminal region Macoilin PF09726.9 PIK33597.1 - 0.025 13.2 11.7 0.028 13.0 11.7 1.0 1 0 0 1 1 1 0 Macoilin family PNISR PF15996.5 PIK33597.1 - 0.03 14.6 7.3 0.043 14.1 7.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR FancD2 PF14631.6 PIK33597.1 - 0.064 10.7 4.3 0.079 10.4 4.3 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease ORC6 PF05460.13 PIK33597.1 - 0.065 12.5 8.4 0.076 12.3 8.4 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pol_alpha_B_N PF08418.10 PIK33597.1 - 0.11 12.4 13.4 0.56 10.1 13.4 1.9 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Hid1 PF12722.7 PIK33597.1 - 0.33 9.1 8.3 0.38 8.8 8.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein KCT2 PF17818.1 PIK33597.1 - 0.49 10.5 8.7 0.84 9.7 8.7 1.3 1 0 0 1 1 1 0 Keratinocyte-associated gene product TMEM215 PF15746.5 PIK33597.1 - 0.63 9.5 3.7 0.86 9.0 3.7 1.2 1 0 0 1 1 1 0 TMEM215 family NOA36 PF06524.12 PIK33597.1 - 1.3 8.3 8.6 1.8 7.8 8.6 1.3 1 0 0 1 1 1 0 NOA36 protein ALMT PF11744.8 PIK33597.1 - 2 7.2 6.4 2.5 6.8 6.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pox_Ag35 PF03286.14 PIK33597.1 - 3.3 7.4 12.2 3.1 7.5 10.9 1.6 1 1 0 1 1 1 0 Pox virus Ag35 surface protein Vpu PF00558.19 PIK33597.1 - 3.5 7.4 4.4 8.2 6.3 4.4 1.6 1 0 0 1 1 1 0 Vpu protein SpoIIIAH PF12685.7 PIK33597.1 - 3.7 7.3 11.4 5 6.9 11.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein FAM176 PF14851.6 PIK33597.1 - 4.9 6.8 7.4 8.7 6.0 7.4 1.5 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 PIK33597.1 - 5.6 5.6 8.8 6.9 5.3 8.8 1.1 1 0 0 1 1 1 0 Presenilin Cdd1 PF11731.8 PIK33598.1 - 0.05 13.8 0.0 0.069 13.4 0.0 1.3 1 1 0 1 1 1 0 Pathogenicity locus Latarcin PF10279.9 PIK33598.1 - 0.052 14.0 0.8 0.072 13.5 0.8 1.2 1 0 0 1 1 1 0 Latarcin precursor ECH_1 PF00378.20 PIK33599.1 - 9.4e-06 25.1 0.2 1e-05 25.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK33599.1 - 0.002 18.1 0.2 0.016 15.2 0.1 1.9 1 1 1 2 2 2 1 Peptidase family S49 Thump_like PF18096.1 PIK33599.1 - 0.1 12.6 0.8 0.45 10.5 0.1 2.2 1 1 1 2 2 2 0 THUMP domain-like AvrPtoB_bdg PF16847.5 PIK33599.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Avirulence AvrPtoB, BAK1-binding domain zf-B_box PF00643.24 PIK33601.1 - 1.8e-07 31.2 7.9 1.8e-07 31.2 7.9 1.7 2 0 0 2 2 2 1 B-box zinc finger Muted PF14942.6 PIK33601.1 - 0.0076 16.6 4.3 0.014 15.7 4.3 1.4 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein GIT1_C PF12205.8 PIK33601.1 - 0.0097 16.0 1.1 0.0097 16.0 1.1 1.7 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term KH_9 PF17904.1 PIK33601.1 - 0.062 13.7 0.7 2.1 8.8 0.3 2.5 2 0 0 2 2 2 0 FMRP KH0 domain Apolipoprotein PF01442.18 PIK33601.1 - 0.11 12.3 8.9 0.28 11.0 8.9 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fzo_mitofusin PF04799.13 PIK33601.1 - 1.1 8.8 5.2 0.54 9.8 1.8 2.0 1 1 2 3 3 3 0 fzo-like conserved region FMN_dh PF01070.18 PIK33603.1 - 7.1e-55 186.4 1.1 8.6e-55 186.2 1.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK33603.1 - 2.1e-08 33.6 0.4 6.3e-08 32.0 0.1 1.8 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK33603.1 - 3.8e-05 23.0 0.1 5.1e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 PIK33603.1 - 0.006 16.1 0.0 0.0086 15.6 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 PIK33603.1 - 0.0089 15.5 1.0 0.01 15.2 1.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 PIK33603.1 - 0.036 13.4 0.6 0.21 10.9 0.0 2.2 1 1 0 3 3 3 0 Thiazole biosynthesis protein ThiG BACK PF07707.15 PIK33604.1 - 4.6e-25 87.7 4.4 4.6e-25 87.7 4.4 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 PIK33604.1 - 6.3e-14 52.2 0.7 1.7e-13 50.7 0.7 1.8 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 PIK33604.1 - 0.00042 20.4 2.3 0.42 10.9 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3342) Kelch_1 PF01344.25 PIK33604.1 - 0.0034 16.9 0.3 0.027 14.1 0.3 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 PIK33604.1 - 0.1 12.6 0.0 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 Kelch motif DUF2121 PF09894.9 PIK33605.1 - 0.13 11.8 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) Hpre_diP_synt_I PF07456.11 PIK33606.1 - 0.049 13.7 0.1 0.062 13.3 0.1 1.1 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase component I EGF_2 PF07974.13 PIK33606.1 - 0.12 12.8 1.9 0.29 11.5 1.9 1.7 1 1 0 1 1 1 0 EGF-like domain EGF_alliinase PF04863.13 PIK33606.1 - 1.3 9.5 7.1 6.3 7.3 3.9 2.8 2 1 0 2 2 2 0 Alliinase EGF-like domain hEGF PF12661.7 PIK33606.1 - 2.9 8.7 5.3 1 10.1 1.7 2.2 2 0 0 2 2 2 0 Human growth factor-like EGF 7tm_2 PF00002.24 PIK33607.1 - 2.9e-26 92.3 21.9 3.8e-26 91.9 21.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK33607.1 - 4.3e-11 43.2 3.8 1.1e-10 41.9 3.8 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF2985 PF11204.8 PIK33607.1 - 0.12 12.5 2.0 0.3 11.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2985) YIF1 PF03878.15 PIK33608.1 - 1.9e-87 292.8 3.1 2.2e-87 292.6 3.1 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 PIK33608.1 - 1.5e-08 34.5 6.6 1.5e-08 34.5 6.6 1.6 2 0 0 2 2 2 1 Yip1 domain ApoA-II PF04711.13 PIK33608.1 - 0.026 14.7 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) PsbL PF02419.17 PIK33608.1 - 8.7 6.4 7.0 65 3.6 1.0 3.6 3 1 0 3 3 3 0 PsbL protein eIF-1a PF01176.19 PIK33609.1 - 6.4e-18 64.3 0.1 1e-17 63.7 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 MBOAT PF03062.19 PIK33610.1 - 4e-24 85.6 20.1 4e-24 85.6 20.1 2.4 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family RabGAP-TBC PF00566.18 PIK33611.1 - 1.6e-48 165.3 8.2 2.4e-48 164.6 8.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 PIK33611.1 - 9.6e-20 70.7 0.0 2.6e-19 69.3 0.0 1.7 2 0 0 2 2 2 1 Rab-binding domain (RBD) Epimerase PF01370.21 PIK33612.1 - 1.8e-41 142.2 0.0 2.7e-38 131.8 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK33612.1 - 0.00016 21.2 0.0 0.00024 20.6 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NICE-3 PF07406.11 PIK33612.1 - 0.075 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 NICE-3 protein DUF4972 PF16342.5 PIK33613.1 - 0.046 13.4 0.1 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) Dam PF05869.11 PIK33614.1 - 0.079 12.5 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) GPS PF01825.21 PIK33615.1 - 7.1e-15 55.3 2.8 1.1e-14 54.7 2.8 1.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK33615.1 - 5.9e-11 42.1 12.8 6.9e-09 35.4 5.1 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) 7TM_GPCR_Srh PF10318.9 PIK33615.1 - 0.0068 15.5 10.4 0.0098 15.0 10.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srh Bax1-I PF01027.20 PIK33615.1 - 0.017 15.0 6.5 0.017 15.0 6.5 2.1 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 UPF0139 PF03669.13 PIK33615.1 - 0.039 13.8 0.2 0.039 13.8 0.2 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) DUF2956 PF11169.8 PIK33615.1 - 0.15 12.2 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Rab5ip PF07019.12 PIK33615.1 - 6.2 7.5 14.6 1.2 9.8 2.8 3.0 3 0 0 3 3 3 0 Rab5-interacting protein (Rab5ip) NIF3 PF01784.18 PIK33616.1 - 3.6e-32 111.9 0.0 4.4e-32 111.7 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) PAF PF15715.5 PIK33618.1 - 2.7e-23 83.1 22.4 2.7e-23 83.1 22.4 2.1 1 1 1 2 2 2 1 PCNA-associated factor histone like domain DNA_pol_phi PF04931.13 PIK33619.1 - 0.06 11.5 2.9 2.4 6.2 0.5 2.1 2 0 0 2 2 2 0 DNA polymerase phi Pkinase PF00069.25 PIK33623.1 - 1.4e-09 37.8 0.0 1.6e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK33623.1 - 8.5e-07 28.5 0.1 1e-06 28.2 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 PIK33623.1 - 0.021 15.0 0.3 0.2 11.8 0.0 1.9 1 1 0 2 2 2 0 ABC1 family TBK1_CCD1 PF18394.1 PIK33624.1 - 1.1e-26 94.0 11.3 2.5e-26 92.8 11.3 1.6 1 0 0 1 1 1 1 TANK-binding kinase 1 coiled-coil domain 1 Pkinase PF00069.25 PIK33624.1 - 7.7e-17 61.5 0.0 2.1e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain TBK1_ULD PF18396.1 PIK33624.1 - 1e-11 44.6 0.0 2.6e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_Tyr PF07714.17 PIK33624.1 - 1.8e-05 24.2 0.0 4.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK33624.1 - 0.03 13.6 0.1 0.098 11.9 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Fungal_trans_2 PF11951.8 PIK33625.1 - 0.036 12.9 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Mucin2_WxxW PF13330.6 PIK33627.1 - 0.0072 17.1 1.1 0.017 15.9 0.1 1.9 2 0 0 2 2 2 1 Mucin-2 protein WxxW repeating region Mucin2_WxxW PF13330.6 PIK33628.1 - 1.4e-20 73.9 27.3 4.6e-10 40.2 7.7 3.7 3 0 0 3 3 3 2 Mucin-2 protein WxxW repeating region DUF5008 PF16400.5 PIK33628.1 - 0.017 15.2 0.3 12 6.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5008) A2M_recep PF07677.14 PIK33628.1 - 0.38 11.5 2.0 30 5.4 0.1 2.7 2 0 0 2 2 2 0 A-macroglobulin receptor binding domain Paramyxo_P PF01806.17 PIK33628.1 - 4 6.8 8.4 6.8 6.1 0.1 3.1 3 0 0 3 3 3 0 Paramyxovirinae P phosphoprotein C-terminal region ATG_C PF09333.11 PIK33629.1 - 0.079 13.3 3.0 3.5 8.0 0.0 3.8 3 1 2 5 5 5 0 Autophagy-related protein C terminal domain NADHdh_A3 PF14987.6 PIK33630.1 - 0.0031 17.8 65.5 3 8.2 0.6 13.8 1 1 16 17 17 17 11 NADH dehydrogenase 1 alpha subcomplex subunit 3 DUF1010 PF06231.11 PIK33630.1 - 0.042 14.4 9.8 20 5.8 0.1 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF1010) Mucin2_WxxW PF13330.6 PIK33631.1 - 3.4e-26 91.9 10.2 4.3e-14 53.1 3.0 2.8 2 0 0 2 2 2 2 Mucin-2 protein WxxW repeating region CC2-LZ PF16516.5 PIK33632.1 - 0.00021 21.6 3.0 0.00021 21.6 3.0 1.6 2 0 0 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator GRP PF07172.11 PIK33632.1 - 0.016 15.9 16.0 0.025 15.3 16.0 1.4 1 0 0 1 1 1 0 Glycine rich protein family Mut7-C PF01927.16 PIK33632.1 - 0.1 12.7 0.3 0.1 12.7 0.3 1.7 2 0 0 2 2 2 0 Mut7-C RNAse domain DUF4127 PF13552.6 PIK33632.1 - 0.11 11.1 0.5 0.13 10.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) zf-C2H2_4 PF13894.6 PIK33632.1 - 0.19 12.6 3.3 0.36 11.8 3.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger DivIC PF04977.15 PIK33632.1 - 0.28 11.0 3.2 0.47 10.2 3.2 1.4 1 0 0 1 1 1 0 Septum formation initiator MULE PF10551.9 PIK33633.1 - 8.7e-08 32.5 0.0 2.1e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 PIK33633.1 - 7.1e-06 26.0 0.1 0.0065 16.6 0.0 3.1 3 0 0 3 3 3 2 FLYWCH zinc finger domain PSD5 PF07637.11 PIK33633.1 - 0.02 15.2 3.4 5.2 7.5 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) DUF5137 PF17220.3 PIK33635.1 - 0.17 12.8 2.0 3.8 8.4 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF5137) MIR PF02815.19 PIK33637.1 - 1.2e-17 64.4 0.0 2.3e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 MIR domain RYDR_ITPR PF01365.21 PIK33637.1 - 2.2e-06 27.2 0.5 3.4e-06 26.6 0.5 1.3 1 0 0 1 1 1 1 RIH domain Ins145_P3_rec PF08709.11 PIK33638.1 - 6.8e-34 116.9 0.1 2.1e-32 112.1 0.1 2.1 1 1 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 PIK33638.1 - 7.2e-17 61.8 0.0 1.1e-13 51.4 0.0 2.3 2 0 0 2 2 2 2 MIR domain Trp_leader1 PF08055.11 PIK33638.1 - 0.12 12.1 1.3 0.37 10.5 1.3 1.8 1 0 0 1 1 1 0 Tryptophan leader peptide Sulfotransfer_1 PF00685.27 PIK33639.1 - 2.1e-13 50.4 0.0 4.9e-13 49.2 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK33640.1 - 9e-48 163.1 2.0 3.9e-47 161.0 0.5 2.2 2 1 1 3 3 3 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK33640.1 - 0.0099 16.3 0.0 0.018 15.5 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family TNFR_c6 PF00020.18 PIK33641.1 - 0.00072 19.9 5.5 1.1 9.8 0.6 3.6 2 2 1 3 3 3 3 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK33641.1 - 0.0015 18.2 14.7 0.096 12.5 1.9 3.7 2 1 1 3 3 3 3 Putative ephrin-receptor like Ig_3 PF13927.6 PIK33644.1 - 2.4e-26 92.1 6.5 5.9e-12 46.0 0.7 3.3 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK33644.1 - 2.3e-24 85.3 0.3 3.6e-11 43.0 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK33644.1 - 1.1e-18 67.3 1.2 2.1e-07 31.2 0.2 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK33644.1 - 3.1e-14 52.9 2.0 3.6e-07 30.2 0.4 3.4 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK33644.1 - 4.5e-12 46.1 1.9 2.9e-05 24.2 0.0 4.4 3 2 2 5 5 5 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK33644.1 - 2.2e-08 33.5 0.0 0.074 12.6 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 PIK33644.1 - 0.00073 19.7 0.9 4 7.8 0.0 3.6 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK33645.1 - 6.8e-44 147.9 4.5 1.1e-13 51.0 0.0 6.0 6 0 0 6 6 6 5 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK33645.1 - 3.9e-36 123.5 10.0 6.7e-09 36.2 0.1 6.4 6 1 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 PIK33645.1 - 7e-30 103.2 6.1 3.9e-08 33.5 0.2 6.6 6 1 0 6 6 6 4 Immunoglobulin domain I-set PF07679.16 PIK33645.1 - 8.3e-27 93.1 0.8 1.7e-07 31.2 0.1 5.6 6 0 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.25 PIK33645.1 - 2.1e-23 82.3 5.6 0.0001 22.4 0.1 6.5 7 0 0 7 7 7 4 Immunoglobulin domain C1-set PF07654.15 PIK33645.1 - 3.7e-13 49.6 0.1 0.0068 16.8 0.0 5.0 5 1 0 5 5 5 3 Immunoglobulin C1-set domain V-set PF07686.17 PIK33645.1 - 4.2e-10 39.8 0.5 0.17 12.1 0.0 5.7 5 1 0 5 5 5 3 Immunoglobulin V-set domain BiPBP_C PF06832.12 PIK33645.1 - 8.6e-07 28.9 0.1 0.56 10.3 0.0 3.6 3 0 0 3 3 3 3 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 PIK33645.1 - 9.6e-05 22.6 0.7 5.1 7.4 0.0 6.1 6 2 1 7 7 7 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 PIK33645.1 - 0.029 14.4 0.5 3.9 7.6 0.0 3.5 3 0 0 3 3 3 0 C17orf99 Ig domain SAG PF04092.13 PIK33645.1 - 0.16 12.8 5.2 23 5.8 0.2 3.8 3 1 0 3 3 3 0 SRS domain 7tm_1 PF00001.21 PIK33646.1 - 1.2e-46 159.1 12.8 1.4e-46 159.0 12.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK33646.1 - 0.0035 17.1 6.8 0.057 13.1 0.5 2.5 2 1 0 2 2 2 2 Olfactory receptor FA_desaturase PF00487.24 PIK33646.1 - 0.19 11.6 10.4 0.032 14.1 4.1 2.1 1 1 1 2 2 2 0 Fatty acid desaturase Phage_AlpA PF05930.12 PIK33647.1 - 0.0085 15.9 0.0 0.87 9.5 0.0 2.4 2 0 0 2 2 2 2 Prophage CP4-57 regulatory protein (AlpA) rve PF00665.26 PIK33650.1 - 5.5e-16 58.8 0.1 1.7e-15 57.3 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK33650.1 - 0.0016 18.6 0.6 0.0031 17.7 0.6 1.5 1 0 0 1 1 1 1 DDE domain FOP_dimer PF09398.10 PIK33650.1 - 0.19 12.0 0.4 8.7 6.7 0.3 2.3 1 1 1 2 2 2 0 FOP N terminal dimerisation domain zf-C2H2 PF00096.26 PIK33651.1 - 0.00057 20.2 21.6 0.012 16.0 4.8 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 PIK33651.1 - 1.5 8.6 4.4 3.6 7.3 0.2 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_4 PF13894.6 PIK33651.1 - 8.3 7.5 19.2 6 8.0 1.9 4.4 3 0 0 3 3 3 0 C2H2-type zinc finger DNA_pol_B_2 PF03175.13 PIK33652.1 - 6.7e-06 25.2 0.3 0.026 13.4 0.1 2.3 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral GlutR_dimer PF00745.20 PIK33652.1 - 0.17 12.4 0.0 0.63 10.5 0.0 1.9 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Herpes_teg_N PF04843.12 PIK33653.1 - 3.4e-10 39.8 0.0 4.8e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus tegument protein, N-terminal conserved region FlgT_M PF16539.5 PIK33653.1 - 0.047 13.8 0.4 0.4 10.8 0.1 2.5 2 1 1 3 3 3 0 Flagellar assembly protein T, middle domain DUF2753 PF10952.8 PIK33653.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) CUB PF00431.20 PIK33654.1 - 7.6e-11 42.3 0.0 1.2e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 CUB domain TSP_1 PF00090.19 PIK33654.1 - 6.8e-07 29.4 8.1 1.1e-06 28.7 8.1 1.4 1 0 0 1 1 1 1 Thrombospondin type 1 domain RCC1 PF00415.18 PIK33655.1 - 4.7e-16 59.1 15.9 1.4e-13 51.2 1.9 4.4 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK33655.1 - 1.4e-11 43.9 11.6 5.1e-06 26.1 0.7 4.7 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 PIK33655.1 - 0.0018 18.1 1.5 11 5.7 0.2 3.0 2 1 1 3 3 3 3 TUP1-like enhancer of split Cyt-b5 PF00173.28 PIK33656.1 - 1.2e-14 54.2 0.0 2.7e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RCC1 PF00415.18 PIK33656.1 - 1.5e-10 41.5 2.1 2.1e-10 41.1 0.6 2.1 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK33656.1 - 0.0002 21.1 0.1 0.00045 19.9 0.1 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat MIB_HERC2 PF06701.13 PIK33656.1 - 0.00024 21.3 0.1 0.00071 19.8 0.1 1.8 1 0 0 1 1 1 1 Mib_herc2 FANCI_S3 PF14677.6 PIK33656.1 - 0.018 14.8 3.8 1.3 8.7 2.4 2.4 2 0 0 2 2 2 0 FANCI solenoid 3 Cul7 PF11515.8 PIK33657.1 - 2.2e-17 63.1 0.2 4e-17 62.3 0.2 1.4 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 Cwf_Cwc_15 PF04889.12 PIK33657.1 - 0.00019 21.2 0.7 0.00028 20.7 0.7 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NUC205 PF08168.11 PIK33657.1 - 0.03 13.8 0.3 0.076 12.5 0.3 1.7 1 0 0 1 1 1 0 NUC205 domain RCC1 PF00415.18 PIK33658.1 - 2.2e-76 252.3 18.9 2e-14 53.9 0.0 7.9 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK33658.1 - 1.6e-33 113.8 42.3 6.4e-08 32.2 0.1 8.8 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat ZZ PF00569.17 PIK33658.1 - 6.6e-11 41.9 4.7 1.6e-10 40.6 4.7 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type SH3_15 PF18346.1 PIK33658.1 - 8.4e-06 26.0 2.5 2.2e-05 24.7 0.8 2.5 2 0 0 2 2 2 1 Mind bomb SH3 repeat domain ANAPC10 PF03256.16 PIK33658.1 - 0.0021 17.7 0.1 0.0042 16.8 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-UBR PF02207.20 PIK33658.1 - 0.064 13.4 1.3 0.2 11.8 1.3 1.9 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Hira PF07569.11 PIK33658.1 - 0.14 11.8 1.3 23 4.6 0.1 3.9 4 1 0 4 4 4 0 TUP1-like enhancer of split RCC1 PF00415.18 PIK33659.1 - 1.1e-92 304.4 24.5 2.5e-16 60.0 0.1 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK33659.1 - 1.5e-39 133.0 42.9 4.9e-08 32.6 0.8 8.4 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Ubie_methyltran PF01209.18 PIK33659.1 - 0.045 13.1 0.3 2.3 7.5 0.1 2.6 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family DUF2848 PF11010.8 PIK33660.1 - 0.037 13.6 0.1 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2848) Na_trans_assoc PF06512.13 PIK33660.1 - 0.066 13.5 2.3 0.089 13.1 2.3 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated TPR_12 PF13424.6 PIK33660.1 - 0.13 12.6 3.8 0.19 12.0 2.8 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK33660.1 - 5 7.6 6.2 6.4 7.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MIF4G PF02854.19 PIK33661.1 - 9e-11 41.8 1.2 1e-08 35.1 0.1 2.1 1 1 1 2 2 2 2 MIF4G domain Methyltr_RsmB-F PF01189.17 PIK33663.1 - 4e-31 108.2 0.0 1.3e-29 103.3 0.0 3.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Peptidase_S10 PF00450.22 PIK33664.1 - 1.9e-127 426.2 0.1 2.2e-127 426.0 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S9 PF00326.21 PIK33664.1 - 0.11 11.9 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_15 PF00723.21 PIK33665.1 - 1e-12 47.6 0.0 1.2e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Tctex-1 PF03645.13 PIK33666.1 - 1.2e-25 89.8 0.1 1.5e-25 89.4 0.1 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF1953 PF09196.10 PIK33666.1 - 0.043 13.6 0.2 0.073 12.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) Tctex-1 PF03645.13 PIK33667.1 - 9.5e-26 90.0 0.1 1.1e-25 89.8 0.1 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF1953 PF09196.10 PIK33667.1 - 0.027 14.3 0.1 0.041 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) OCRE PF17780.1 PIK33668.1 - 5e-15 55.3 13.9 9.2e-15 54.4 13.9 1.5 1 0 0 1 1 1 1 OCRE domain G-patch PF01585.23 PIK33668.1 - 1.8e-12 46.9 4.4 5.3e-12 45.4 4.4 1.9 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 PIK33668.1 - 4e-11 43.1 0.0 8.9e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.7 PIK33668.1 - 6.7e-05 22.9 0.2 6.7e-05 22.9 0.2 2.5 2 0 0 2 2 2 1 G-patch domain Yop-YscD_cpl PF16697.5 PIK33668.1 - 0.01 16.1 0.0 0.032 14.5 0.0 1.9 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain KRE1 PF17056.5 PIK33668.1 - 0.1 12.3 1.0 12 5.7 0.1 2.5 2 0 0 2 2 2 0 Killer toxin-resistance protein 1 Ank_5 PF13857.6 PIK33669.1 - 1.6e-13 50.6 0.0 1.1e-08 35.1 0.0 4.8 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK33669.1 - 4.4e-12 46.4 0.0 1e-11 45.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) LEM PF03020.15 PIK33669.1 - 1.1e-10 40.9 0.4 3.1e-10 39.4 0.4 1.8 1 0 0 1 1 1 1 LEM domain Ank_4 PF13637.6 PIK33669.1 - 1.2e-10 41.6 0.0 2.3e-08 34.4 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK33669.1 - 2.9e-09 37.0 0.0 0.0026 18.1 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK33669.1 - 9.4e-09 34.8 0.1 0.0085 16.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Abhydrolase_1 PF00561.20 PIK33670.1 - 1.8e-22 80.2 0.0 1.2e-20 74.2 0.0 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK33670.1 - 3.5e-17 63.8 0.0 5.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK33670.1 - 4e-15 55.7 0.0 1.2e-13 50.9 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 PIK33670.1 - 3.3e-05 24.1 0.6 0.12 12.5 0.0 2.5 3 0 0 3 3 3 2 Thioesterase domain FSH1 PF03959.13 PIK33670.1 - 0.0014 18.3 0.0 0.011 15.5 0.0 2.3 1 1 1 2 2 2 1 Serine hydrolase (FSH1) DLH PF01738.18 PIK33670.1 - 0.0079 15.8 0.0 0.96 9.0 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 PIK33670.1 - 0.034 13.7 0.1 2.2 7.8 0.0 2.6 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_8 PF06259.12 PIK33670.1 - 0.072 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase LIDHydrolase PF10230.9 PIK33670.1 - 0.079 12.5 0.0 0.91 9.0 0.0 2.1 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 PIK33670.1 - 0.11 12.3 0.4 9.6 5.9 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Ser_hydrolase PF06821.13 PIK33670.1 - 0.16 11.9 0.0 6.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase Kelch_1 PF01344.25 PIK33671.1 - 1.6e-25 88.4 5.2 1.6e-10 40.4 0.0 5.6 5 2 0 5 5 5 3 Kelch motif BTB PF00651.31 PIK33671.1 - 6.1e-25 87.6 0.4 1.5e-24 86.4 0.4 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 PIK33671.1 - 8.5e-22 76.7 6.7 2.4e-09 37.1 0.0 5.3 2 2 2 4 4 4 4 Kelch motif BACK PF07707.15 PIK33671.1 - 4.3e-21 74.9 2.2 9.3e-21 73.9 2.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 PIK33671.1 - 2.8e-12 46.6 2.6 0.0025 18.1 0.0 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK33671.1 - 5.7e-11 42.3 1.5 0.0023 17.9 0.0 4.6 3 2 2 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK33671.1 - 7.8e-10 38.3 1.5 0.021 14.8 0.0 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 PIK33671.1 - 4.7e-09 36.0 0.2 3.3e-06 26.9 0.0 3.4 3 0 0 3 3 3 1 Kelch motif MFS_1 PF07690.16 PIK33672.1 - 3.2e-41 141.5 23.0 3.2e-41 141.5 23.0 2.6 2 1 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK33672.1 - 2.8e-07 29.8 24.9 3.2e-05 23.0 4.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 PIK33672.1 - 0.055 11.7 16.0 0.027 12.8 2.3 2.9 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 PIK33672.1 - 0.066 11.6 16.8 0.13 10.6 16.4 1.6 1 1 0 1 1 1 0 Transmembrane secretion effector TssN PF17555.2 PIK33672.1 - 9.3 5.5 14.4 5.7 6.2 3.8 2.5 2 1 0 2 2 2 0 Type VI secretion system, TssN SWIRM-assoc_2 PF16496.5 PIK33673.1 - 0.035 13.0 0.0 0.043 12.7 0.0 1.0 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal TACC_C PF05010.14 PIK33674.1 - 0.0026 17.6 13.0 0.0026 17.6 13.0 1.7 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4407 PF14362.6 PIK33674.1 - 0.021 14.2 2.9 0.026 13.9 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 PIK33674.1 - 0.31 11.1 22.3 0.56 10.3 4.6 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain SHE3 PF17078.5 PIK33674.1 - 1.4 8.6 18.6 1.4 8.6 16.0 1.9 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF3340 PF11818.8 PIK33674.1 - 1.6 8.9 17.8 0.11 12.6 13.0 1.5 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) Spc7 PF08317.11 PIK33674.1 - 3.3 6.5 18.3 7.3 5.4 18.3 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 PIK33674.1 - 6.5 4.5 11.2 9.2 4.0 11.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM76 PF16046.5 PIK33674.1 - 7.9 5.7 14.4 27 4.0 14.4 1.8 1 1 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 PIK33674.1 - 8.3 5.9 13.2 11 5.5 13.1 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_C14 PF00656.22 PIK33675.1 - 1.3e-45 156.3 0.0 1.7e-45 156.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain SHE3 PF17078.5 PIK33676.1 - 4.7e-05 23.2 18.9 4.7e-05 23.2 18.9 1.9 1 1 1 2 2 2 1 SWI5-dependent HO expression protein 3 CCDC144C PF14915.6 PIK33676.1 - 0.00029 20.1 30.1 0.00034 19.8 12.0 2.1 1 1 1 2 2 2 2 CCDC144C protein coiled-coil region Tmemb_cc2 PF10267.9 PIK33676.1 - 0.0008 18.7 12.9 0.0008 18.7 12.9 2.3 1 1 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein ERM PF00769.19 PIK33676.1 - 0.002 18.0 35.0 0.024 14.5 18.6 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family Tropomyosin_1 PF12718.7 PIK33676.1 - 0.026 14.7 35.0 0.07 13.3 8.2 2.6 1 1 1 2 2 2 0 Tropomyosin like ATG16 PF08614.11 PIK33676.1 - 0.035 14.3 33.0 0.18 12.0 13.4 3.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) GAS PF13851.6 PIK33676.1 - 0.075 12.4 34.7 0.34 10.3 30.2 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding CorA PF01544.18 PIK33676.1 - 0.11 11.8 7.6 0.3 10.4 7.5 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein AAA_13 PF13166.6 PIK33676.1 - 0.11 11.1 21.1 0.15 10.7 21.1 1.1 1 0 0 1 1 1 0 AAA domain Bacillus_HBL PF05791.11 PIK33676.1 - 0.31 10.8 15.9 0.039 13.8 8.9 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3450 PF11932.8 PIK33676.1 - 0.59 9.4 27.6 0.36 10.1 12.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Sec20 PF03908.13 PIK33676.1 - 0.8 9.7 12.0 0.079 12.9 3.6 2.7 2 1 1 3 3 3 0 Sec20 Fib_alpha PF08702.10 PIK33676.1 - 0.82 9.9 20.7 0.95 9.6 8.8 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 PIK33676.1 - 0.86 9.6 36.3 1.8 8.6 16.4 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 PIK33676.1 - 0.93 8.3 34.3 0.34 9.8 17.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4559 PF15112.6 PIK33676.1 - 1.1 8.9 18.8 0.21 11.2 15.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) 60KD_IMP PF02096.20 PIK33676.1 - 1.1 9.1 11.0 0.75 9.7 7.9 2.0 2 0 0 2 2 2 0 60Kd inner membrane protein TPR_MLP1_2 PF07926.12 PIK33676.1 - 1.2 9.2 35.0 0.13 12.3 20.7 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3573 PF12097.8 PIK33676.1 - 1.2 7.8 4.1 1.1 8.0 3.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) ParB PF08775.10 PIK33676.1 - 1.3 9.5 14.4 0.13 12.8 8.3 2.2 2 1 1 3 3 3 0 ParB family Lebercilin PF15619.6 PIK33676.1 - 1.3 8.6 34.5 0.91 9.2 12.0 2.6 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SlyX PF04102.12 PIK33676.1 - 1.9 9.2 27.0 0.53 10.9 2.2 4.7 1 1 2 3 3 3 0 SlyX BRE1 PF08647.11 PIK33676.1 - 1.9 8.6 32.2 0.63 10.2 14.1 3.6 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase DUF812 PF05667.11 PIK33676.1 - 2.2 7.1 27.3 4 6.2 27.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) SAB PF04382.13 PIK33676.1 - 2.2 8.4 8.3 4.4 7.5 1.6 2.7 1 1 1 2 2 2 0 SAB domain HisKA_3 PF07730.13 PIK33676.1 - 2.4 8.7 12.5 11 6.6 0.4 3.6 2 2 2 4 4 4 0 Histidine kinase Vps5 PF09325.10 PIK33676.1 - 3.6 7.1 23.7 6.8 6.2 23.7 1.5 1 1 0 1 1 1 0 Vps5 C terminal like DivIVA PF05103.13 PIK33676.1 - 4.4 7.4 22.8 0.34 11.0 3.9 3.4 1 1 2 3 3 3 0 DivIVA protein DHR10 PF18595.1 PIK33676.1 - 6.1 6.9 35.6 2.1 8.4 21.2 3.3 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain CagS PF16707.5 PIK33676.1 - 6.8 6.6 11.4 8.8 6.3 0.1 2.2 2 0 0 2 2 2 0 Cag pathogenicity island protein S of Helicobacter pylori DUF4407 PF14362.6 PIK33676.1 - 7.2 5.9 20.6 36 3.6 20.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 PIK33676.1 - 7.6 6.6 18.1 0.74 9.9 8.5 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) COG5 PF10392.9 PIK33676.1 - 8 6.6 13.0 0.22 11.7 3.4 2.6 1 1 1 3 3 3 0 Golgi transport complex subunit 5 KxDL PF10241.9 PIK33676.1 - 9 6.7 21.3 3.4 8.0 2.8 3.6 1 1 2 3 3 3 0 Uncharacterized conserved protein BLOC1_2 PF10046.9 PIK33676.1 - 9.6 6.6 18.9 0.93 9.8 8.7 3.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HYR PF02494.16 PIK33677.1 - 7.6e-29 99.9 0.8 1.7e-16 60.3 0.1 2.7 2 0 0 2 2 2 2 HYR domain Ephrin_rec_like PF07699.13 PIK33677.1 - 4.1e-27 93.7 46.8 2.9e-13 49.3 7.4 6.7 5 1 1 6 6 6 4 Putative ephrin-receptor like EGF PF00008.27 PIK33677.1 - 7e-26 90.2 91.5 5.9e-07 29.7 4.0 8.8 8 0 0 8 8 6 5 EGF-like domain Pentaxin PF00354.17 PIK33677.1 - 3.4e-23 82.4 0.0 6.6e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Pentaxin family Sushi PF00084.20 PIK33677.1 - 1.7e-20 73.4 51.7 6.2e-07 29.9 2.6 6.9 7 0 0 7 7 6 5 Sushi repeat (SCR repeat) hEGF PF12661.7 PIK33677.1 - 1.2e-14 54.3 89.7 0.00013 22.4 6.1 10.1 10 0 0 10 10 9 6 Human growth factor-like EGF Laminin_G_3 PF13385.6 PIK33677.1 - 7.1e-13 49.0 0.1 1.3e-12 48.1 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily VWA PF00092.28 PIK33677.1 - 0.00047 20.5 0.0 0.00079 19.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF_CA PF07645.15 PIK33677.1 - 0.0011 19.1 12.1 0.0011 19.1 12.1 11.7 9 3 3 12 12 10 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK33677.1 - 0.17 12.3 98.0 0.1 13.0 5.4 8.5 6 0 0 6 6 5 0 EGF-like domain EGF_3 PF12947.7 PIK33677.1 - 0.48 10.7 91.7 0.026 14.7 6.0 9.4 9 1 0 9 9 9 0 EGF domain Sushi PF00084.20 PIK33678.1 - 2.8e-94 309.6 55.5 3.5e-11 43.5 1.2 10.1 10 0 0 10 10 10 10 Sushi repeat (SCR repeat) HRM PF02793.22 PIK33678.1 - 0.0003 21.0 38.1 1.7 9.0 1.1 9.2 8 1 1 9 9 9 6 Hormone receptor domain PPR_1 PF12854.7 PIK33678.1 - 0.086 12.6 0.0 0.26 11.0 0.0 1.8 1 0 0 1 1 1 0 PPR repeat U71 PF17474.2 PIK33678.1 - 9.8 6.2 25.3 17 5.4 0.0 6.3 7 0 0 7 7 7 0 Tegument protein UL11 homolog Sushi PF00084.20 PIK33679.1 - 2.6e-19 69.5 5.9 5.6e-09 36.5 0.6 3.0 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) U71 PF17474.2 PIK33679.1 - 0.069 13.1 4.5 16 5.5 0.1 3.2 3 0 0 3 3 3 0 Tegument protein UL11 homolog Phage_glycop_gL PF11108.8 PIK33679.1 - 0.1 12.6 0.1 17 5.6 0.0 2.2 2 0 0 2 2 2 0 Viral glycoprotein L Sushi PF00084.20 PIK33680.1 - 1.4e-88 291.4 52.5 2.8e-12 47.0 1.0 9.1 9 0 0 9 9 9 9 Sushi repeat (SCR repeat) HRM PF02793.22 PIK33680.1 - 1.1e-05 25.6 36.1 0.24 11.7 0.1 8.2 8 1 1 9 9 9 5 Hormone receptor domain DUF281 PF03436.13 PIK33680.1 - 0.072 13.5 9.3 3 8.3 0.7 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF281) cEGF PF12662.7 PIK33680.1 - 4.4 7.3 29.6 3.8 7.5 0.4 9.0 9 0 0 9 9 9 0 Complement Clr-like EGF-like Hep_core_N PF08290.11 PIK33680.1 - 8 6.6 10.0 5.2 7.2 0.7 3.7 3 0 0 3 3 3 0 Hepatitis core protein, putative zinc finger SelP_N PF04592.14 PIK33681.1 - 3.8e-30 105.0 0.0 5.5e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region SelP_N PF04592.14 PIK33682.1 - 4.8e-29 101.4 0.0 1.2e-28 100.1 0.0 1.6 1 1 0 1 1 1 1 Selenoprotein P, N terminal region RBD-FIP PF09457.10 PIK33683.1 - 0.0017 18.3 2.0 0.0032 17.3 2.0 1.5 1 0 0 1 1 1 1 FIP domain DUF3213 PF11491.8 PIK33683.1 - 0.075 13.2 0.6 0.17 12.1 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) DUF1192 PF06698.11 PIK33683.1 - 0.86 9.7 6.2 0.16 12.0 1.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) DUF3432 PF11914.8 PIK33685.1 - 0.66 10.3 43.8 0.93 9.8 9.3 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF3432) Sina PF03145.16 PIK33686.1 - 1e-70 237.8 0.1 1.1e-70 237.6 0.1 1.0 1 0 0 1 1 1 1 Seven in absentia protein family zf_C2H2_6 PF18450.1 PIK33686.1 - 0.028 14.1 1.4 0.046 13.4 1.4 1.4 1 0 0 1 1 1 0 Zinc Finger domain UCH PF00443.29 PIK33687.1 - 2.2e-11 43.7 0.0 2.3e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK33687.1 - 0.00011 21.9 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 PIK33687.1 - 0.35 10.9 13.7 0.66 10.0 2.3 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif UCH PF00443.29 PIK33688.1 - 3.4e-27 95.6 2.0 5.3e-27 94.9 2.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK33688.1 - 7.7e-16 58.6 3.9 1.2e-15 58.0 3.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.5 PIK33688.1 - 8.9e-09 35.2 0.0 2.8e-08 33.7 0.0 1.9 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 ATF7IP_BD PF16788.5 PIK33688.1 - 1.1 9.3 3.6 1.3 9.1 0.4 2.5 2 0 0 2 2 2 0 ATF-interacting protein binding domain DDE_Tnp_1_7 PF13843.6 PIK33689.1 - 3.5e-57 194.3 0.0 7.4e-37 127.5 0.0 2.1 1 1 1 2 2 2 2 Transposase IS4 Arfaptin PF06456.13 PIK33690.1 - 3.2e-58 197.0 1.8 3.7e-58 196.8 1.8 1.0 1 0 0 1 1 1 1 Arfaptin-like domain Kazal_2 PF07648.15 PIK33691.1 - 7.3e-19 67.6 12.5 1.3e-09 38.0 2.2 2.2 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK33691.1 - 5.2e-17 61.6 11.0 1e-08 35.1 1.4 2.2 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain DUF445 PF04286.12 PIK33692.1 - 0.032 14.0 0.4 0.039 13.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RHH_3 PF12651.7 PIK33692.1 - 0.055 13.4 1.2 0.33 11.0 0.2 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix domain Aminotran_1_2 PF00155.21 PIK33693.1 - 9.3e-17 61.2 0.0 1.3e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 PIK33693.1 - 0.00021 20.8 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK33693.1 - 0.03 13.6 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2976 PF11190.8 PIK33693.1 - 0.15 11.8 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) PDGF_N PF04692.13 PIK33693.1 - 0.16 12.7 1.7 0.35 11.7 1.7 1.5 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region RVT_1 PF00078.27 PIK33694.1 - 5.8e-16 58.7 0.1 8.2e-16 58.2 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Kinesin PF00225.23 PIK33695.1 - 7.8e-27 94.1 0.4 1.6e-25 89.7 0.4 2.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK33695.1 - 2.1e-10 40.7 0.0 7.2e-10 39.0 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding DUF4472 PF14739.6 PIK33695.1 - 8.2e-05 23.3 18.0 0.0032 18.2 0.5 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF4472) Leu_zip PF15294.6 PIK33695.1 - 0.025 14.1 0.7 0.025 14.1 0.7 3.5 3 1 0 4 4 4 0 Leucine zipper TRAF_BIRC3_bd PF16673.5 PIK33695.1 - 0.18 11.6 3.0 0.76 9.6 3.0 2.1 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain H-kinase_dim PF02895.14 PIK33695.1 - 0.36 11.2 4.6 1.2 9.6 0.0 3.3 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain DUF5320 PF17253.2 PIK33695.1 - 4.4 8.4 8.3 10 7.3 0.1 3.5 3 1 0 3 3 3 0 Family of unknown function (DUF5320) Actin PF00022.19 PIK33696.1 - 5.6e-78 262.3 0.0 1.7e-76 257.5 0.0 2.5 1 1 0 1 1 1 1 Actin DUF3480 PF11979.8 PIK33697.1 - 2.9e-83 279.8 0.0 3.9e-83 279.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) DUF3480 PF11979.8 PIK33698.1 - 1.8e-27 96.2 1.3 3.5e-15 55.8 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3480) FYVE PF01363.21 PIK33698.1 - 8.4e-19 67.5 13.4 1.8e-18 66.5 13.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger Fanconi_A_N PF15865.5 PIK33698.1 - 0.083 12.3 0.2 0.17 11.2 0.1 1.5 2 0 0 2 2 2 0 Fanconi anaemia group A protein N terminus zf_C2HC_14 PF18574.1 PIK33698.1 - 0.8 9.5 13.9 0.28 11.0 4.6 2.4 2 0 0 2 2 2 0 C2HC Zing finger domain DC_STAMP PF07782.13 PIK33699.1 - 4.6e-56 189.7 0.1 9.9e-56 188.6 0.1 1.6 1 0 0 1 1 1 1 DC-STAMP-like protein DUF2226 PF09987.9 PIK33699.1 - 0.071 12.5 0.3 0.24 10.7 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) CH PF00307.31 PIK33700.1 - 4.3e-16 59.0 0.0 8.5e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK33700.1 - 2.5e-06 27.2 0.0 4.8e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain RPN2_C PF18004.1 PIK33700.1 - 0.55 10.1 8.6 0.47 10.4 6.9 1.7 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain NARP1 PF12569.8 PIK33700.1 - 3.1 6.6 10.5 4.6 6.0 10.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 HemY_N PF07219.13 PIK33700.1 - 4.6 7.5 7.4 8.1 6.7 7.4 1.3 1 0 0 1 1 1 0 HemY protein N-terminus MORN PF02493.20 PIK33701.1 - 2.3e-49 162.4 71.7 8.4e-07 28.5 3.1 10.5 10 0 0 10 10 10 10 MORN repeat HEPN_STY4199 PF18729.1 PIK33701.1 - 0.23 10.6 0.1 0.34 10.0 0.1 1.2 1 0 0 1 1 1 0 STY4199-like HEPN DUF2475 PF10629.9 PIK33702.1 - 1.6e-26 92.3 1.1 2.6e-26 91.6 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) SE PF08491.10 PIK33703.1 - 5.8e-72 242.1 0.2 1.9e-63 214.1 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase FAD_binding_3 PF01494.19 PIK33703.1 - 1.2e-13 51.0 0.0 1.8e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 PIK33703.1 - 6.5e-07 29.3 0.1 0.0028 17.3 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK33703.1 - 0.00013 22.2 0.3 0.00027 21.1 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 PIK33703.1 - 0.002 18.6 0.1 0.012 16.2 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 PIK33703.1 - 0.0078 15.9 0.1 0.016 14.8 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 PIK33703.1 - 0.0087 14.9 1.2 0.67 8.7 0.3 2.3 1 1 1 2 2 2 2 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 PIK33703.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 PIK33703.1 - 0.017 15.0 0.1 0.029 14.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 PIK33703.1 - 0.018 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 PIK33703.1 - 0.019 15.2 0.1 0.031 14.5 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 PIK33703.1 - 0.031 14.5 0.2 0.06 13.6 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 PIK33703.1 - 0.036 14.2 0.1 0.094 12.9 0.1 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 PIK33703.1 - 0.042 13.9 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DcpS_C PF11969.8 PIK33704.1 - 6.6e-27 94.3 0.0 8.2e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 PIK33704.1 - 1.2e-09 38.8 3.1 3.3e-09 37.4 3.1 1.7 1 1 0 1 1 1 1 HIT domain CwfJ_C_1 PF04677.15 PIK33704.1 - 0.13 12.2 0.4 0.17 11.7 0.0 1.4 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 1 DMA PF03474.14 PIK33705.1 - 7.8e-19 67.0 0.3 1.6e-18 66.0 0.3 1.6 1 0 0 1 1 1 1 DMRTA motif DM PF00751.18 PIK33706.1 - 3.4e-18 65.3 10.8 4.2e-18 65.0 9.9 1.7 1 1 0 1 1 1 1 DM DNA binding domain AAA PF00004.29 PIK33707.1 - 6.1e-41 139.9 0.0 3.6e-40 137.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK33707.1 - 2.2e-10 40.2 0.1 4.4e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 PIK33707.1 - 4.9e-05 23.6 0.0 0.0066 16.7 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 PIK33707.1 - 0.00021 21.3 0.1 0.0015 18.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK33707.1 - 0.00042 20.7 0.1 0.0046 17.4 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 PIK33707.1 - 0.0011 18.5 0.0 0.0021 17.6 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_2 PF07724.14 PIK33707.1 - 0.0035 17.5 0.0 0.012 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 PIK33707.1 - 0.0041 16.9 0.0 0.0094 15.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 PIK33707.1 - 0.0074 15.5 0.0 0.017 14.3 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 PIK33707.1 - 0.0079 16.7 0.0 0.05 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 PIK33707.1 - 0.0085 15.8 0.1 0.12 12.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 PIK33707.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 PIK33707.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK33707.1 - 0.046 14.1 0.0 0.088 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 PIK33707.1 - 0.051 12.8 0.1 0.12 11.5 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain Mg_chelatase PF01078.21 PIK33707.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 PIK33707.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 PIK33707.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK33707.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain zf_Rg PF17915.1 PIK33707.1 - 0.11 11.9 0.1 0.27 10.6 0.1 1.6 1 0 0 1 1 1 0 Reverse gyrase zinc finger IstB_IS21 PF01695.17 PIK33707.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 PIK33707.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ICMT PF04140.14 PIK33708.1 - 1.9e-31 108.4 0.4 1.9e-31 108.4 0.4 2.6 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 PIK33708.1 - 6.1e-10 39.5 0.4 6.1e-10 39.5 0.4 2.8 3 1 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 PIK33708.1 - 0.0068 15.9 0.6 0.013 15.0 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) MerC PF03203.14 PIK33708.1 - 0.1 13.0 11.9 1.3 9.5 11.8 2.4 1 1 0 1 1 1 0 MerC mercury resistance protein DUF3188 PF11384.8 PIK33708.1 - 1.2 8.9 6.5 1.3 8.7 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3188) DUF4381 PF14316.6 PIK33708.1 - 7 6.9 6.2 43 4.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) ABC_tran PF00005.27 PIK33709.1 - 9.1e-37 126.6 0.1 1.7e-36 125.8 0.1 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK33709.1 - 1.4e-08 34.4 1.1 7.3e-07 28.8 0.2 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 PIK33709.1 - 2.1e-08 34.2 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Zeta_toxin PF06414.12 PIK33709.1 - 6e-05 22.4 0.3 0.0066 15.7 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 PIK33709.1 - 8e-05 23.1 0.6 0.00032 21.1 0.6 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK33709.1 - 0.00034 21.1 0.6 0.0053 17.2 0.6 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 PIK33709.1 - 0.00035 20.5 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 PIK33709.1 - 0.00064 20.0 0.2 0.0033 17.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK33709.1 - 0.0023 17.9 0.1 0.074 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 PIK33709.1 - 0.0052 16.5 0.0 0.0085 15.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 PIK33709.1 - 0.0055 16.4 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain APS_kinase PF01583.20 PIK33709.1 - 0.0078 16.1 0.1 0.025 14.5 0.0 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_30 PF13604.6 PIK33709.1 - 0.016 14.9 0.7 0.09 12.5 0.7 1.9 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 PIK33709.1 - 0.028 14.2 0.0 0.37 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 PIK33709.1 - 0.031 14.0 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 PIK33709.1 - 0.034 13.7 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 PIK33709.1 - 0.04 13.8 0.1 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain SbcCD_C PF13558.6 PIK33709.1 - 0.042 14.1 0.5 0.46 10.7 0.5 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Phage_T4_Ndd PF06591.11 PIK33709.1 - 0.043 13.6 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) NACHT PF05729.12 PIK33709.1 - 0.086 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.13 PIK33709.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 PIK33709.1 - 0.13 11.8 0.1 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 PIK33709.1 - 0.14 12.2 0.2 0.61 10.2 0.1 2.0 1 1 1 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 PIK33709.1 - 0.15 11.2 0.1 0.37 9.9 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain RVT_1 PF00078.27 PIK33710.1 - 6.7e-20 71.6 0.0 8.9e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_21 PF13276.6 PIK33712.1 - 0.11 12.7 3.6 0.24 11.6 0.2 2.3 2 0 0 2 2 2 0 HTH-like domain DDE_Tnp_4 PF13359.6 PIK33713.1 - 4.9e-35 120.5 0.0 7.8e-35 119.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK33713.1 - 8.1e-06 25.6 0.1 0.00088 18.9 0.0 2.2 2 0 0 2 2 2 2 Plant transposon protein Tnp_P_element PF12017.8 PIK33714.1 - 0.022 14.2 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Transposase protein zf-RVT PF13966.6 PIK33715.1 - 2e-05 25.2 4.1 2e-05 25.2 4.1 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase MULE PF10551.9 PIK33717.1 - 1.5e-07 31.8 0.0 7.1e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 MULE transposase domain PseudoU_synth_2 PF00849.22 PIK33718.1 - 1.4e-07 31.8 0.0 1.8e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase APCDDC PF14921.6 PIK33719.1 - 1.2e-45 155.8 0.1 2e-45 155.1 0.1 1.3 1 1 0 1 1 1 1 Adenomatosis polyposis coli down-regulated 1 APCDDC PF14921.6 PIK33720.1 - 5.9e-28 97.9 0.2 7.9e-24 84.4 0.0 2.5 2 0 0 2 2 2 2 Adenomatosis polyposis coli down-regulated 1 IMPDH PF00478.25 PIK33721.1 - 1.1e-48 166.1 2.0 3.1e-40 138.2 1.4 2.0 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 PIK33721.1 - 0.00055 19.1 0.7 0.00087 18.4 0.7 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ANAPC4_WD40 PF12894.7 PIK33722.1 - 3.4e-05 24.1 0.2 0.014 15.7 0.2 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK33722.1 - 0.0026 18.6 0.2 0.34 11.9 0.0 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40_like PF17005.5 PIK33722.1 - 0.028 13.7 0.1 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain Frag1 PF10277.9 PIK33723.1 - 1e-22 80.8 13.7 1.3e-22 80.5 13.7 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Sulfotransfer_1 PF00685.27 PIK33725.1 - 1.5e-20 73.8 3.3 1.7e-20 73.6 3.3 1.0 1 0 0 1 1 1 1 Sulfotransferase domain SpoVIF PF14069.6 PIK33725.1 - 0.026 14.3 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 Stage VI sporulation protein F NACHT PF05729.12 PIK33726.1 - 9.7e-11 41.9 0.0 1.9e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK33726.1 - 9.5e-06 25.8 1.4 0.026 14.8 0.2 2.7 2 0 0 2 2 2 2 Death effector domain AAA_25 PF13481.6 PIK33726.1 - 0.00027 20.6 0.0 0.00072 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain GPI2 PF06432.11 PIK33726.1 - 0.0014 18.1 0.4 0.0023 17.4 0.4 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF2095 PF09868.9 PIK33726.1 - 0.0042 17.1 0.0 0.88 9.5 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2095) ATPase PF06745.13 PIK33726.1 - 0.12 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 KaiC Imm25 PF15564.6 PIK33727.1 - 0.014 15.3 0.2 0.025 14.5 0.2 1.4 1 0 0 1 1 1 0 Immunity protein 25 PucR PF07905.11 PIK33728.1 - 0.17 12.2 0.0 3.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family RNA_pol_Rpb2_7 PF04560.20 PIK33729.1 - 1.4e-36 124.7 0.3 1.7e-36 124.5 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_6 PF00562.28 PIK33729.1 - 1.9e-07 30.5 0.1 2.4e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_6 PF00562.28 PIK33730.1 - 8.7e-44 150.1 0.1 1.7e-41 142.6 0.0 2.1 1 1 1 2 2 2 2 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_4 PF04566.13 PIK33730.1 - 2e-25 88.9 0.3 5e-25 87.6 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 PIK33730.1 - 4.7e-10 39.9 4.2 4.7e-10 39.9 4.2 2.7 3 1 0 3 3 3 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_1 PF04563.15 PIK33731.1 - 2.4e-40 138.2 0.1 3e-40 137.9 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 PIK33731.1 - 1.5e-21 76.3 0.0 3.7e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 PIK33731.1 - 8.4e-17 61.4 0.2 1.7e-16 60.4 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Glyco_transf_29 PF00777.18 PIK33732.1 - 1.7e-29 103.1 1.8 3.4e-21 75.9 0.0 2.2 1 1 1 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) HYR PF02494.16 PIK33734.1 - 3.1e-28 97.9 10.3 5.4e-14 52.3 0.4 3.5 3 0 0 3 3 3 3 HYR domain Sushi PF00084.20 PIK33734.1 - 1.5e-11 44.7 15.7 1.6e-06 28.6 5.0 2.8 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) cEGF PF12662.7 PIK33734.1 - 0.62 10.0 8.7 3.2 7.8 1.0 3.2 2 0 0 2 2 2 0 Complement Clr-like EGF-like ZU5 PF00791.20 PIK33735.1 - 3.2e-09 37.0 1.1 8.3e-09 35.7 0.7 1.9 1 1 1 2 2 2 1 ZU5 domain P_C PF06640.11 PIK33736.1 - 0.085 13.0 3.7 0.12 12.5 3.7 1.3 1 0 0 1 1 1 0 P protein C-terminus UCH PF00443.29 PIK33737.1 - 1.2e-40 139.7 0.3 2.3e-40 138.7 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 PIK33737.1 - 4.4e-07 29.8 0.1 1.1e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain UCH_1 PF13423.6 PIK33737.1 - 7.4e-06 25.8 0.0 0.00017 21.3 0.0 2.1 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 PIK33737.1 - 0.07 12.9 0.0 8 6.3 0.1 2.8 2 1 0 2 2 2 0 Ubiquitin family DUSP PF06337.12 PIK33738.1 - 2.9e-15 56.7 0.7 7.6e-15 55.3 0.7 1.6 1 1 0 1 1 1 1 DUSP domain DLIC PF05783.11 PIK33738.1 - 0.42 9.4 4.7 0.51 9.1 4.7 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) EF-hand_6 PF13405.6 PIK33739.1 - 3.9e-17 60.6 1.0 9e-05 22.1 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 PIK33739.1 - 1.2e-16 58.9 1.9 3.2e-05 23.2 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 PIK33739.1 - 4.8e-14 52.6 2.9 1.4e-09 38.3 1.2 2.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK33739.1 - 1.2e-10 40.4 4.9 0.0071 15.8 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK33739.1 - 4.3e-07 29.7 0.2 0.74 9.7 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK33739.1 - 0.00022 21.5 0.3 0.61 10.4 0.0 3.1 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region MIT_C PF16565.5 PIK33741.1 - 0.13 12.3 2.2 0.21 11.6 1.2 1.8 1 1 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT GPS PF01825.21 PIK33742.1 - 3e-15 56.5 2.5 4.5e-15 55.9 2.5 1.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK33742.1 - 1.8e-08 34.0 2.2 3e-08 33.3 2.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 PIK33743.1 - 2.7e-46 158.0 13.7 3.4e-46 157.7 13.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK33743.1 - 0.0068 16.2 6.4 0.075 12.8 0.6 2.4 2 1 0 2 2 2 2 Olfactory receptor FA_desaturase PF00487.24 PIK33743.1 - 0.55 10.0 11.3 0.11 12.3 4.4 2.2 1 1 1 2 2 2 0 Fatty acid desaturase Arm PF00514.23 PIK33745.1 - 1.8e-20 72.2 2.8 8.9e-10 38.3 0.1 3.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK33745.1 - 6.1e-06 26.5 0.1 0.01 16.2 0.0 2.0 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 PIK33745.1 - 0.00013 21.9 0.0 0.18 12.2 0.0 3.0 2 0 0 2 2 2 2 HEAT repeat HEAT_EZ PF13513.6 PIK33745.1 - 0.00058 20.3 0.0 0.12 12.9 0.0 2.9 3 0 0 3 3 3 1 HEAT-like repeat KAP PF05804.12 PIK33745.1 - 0.071 11.2 0.0 0.1 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) Arm_2 PF04826.13 PIK33745.1 - 0.21 11.0 0.2 0.88 9.0 0.2 1.8 1 1 1 2 2 2 0 Armadillo-like Arm PF00514.23 PIK33746.1 - 1.7e-12 46.9 0.4 9.1e-05 22.4 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK33746.1 - 0.046 14.1 0.6 0.099 13.0 0.3 1.6 1 1 0 1 1 1 0 HEAT repeats SIP PF04954.13 PIK33746.1 - 0.14 12.7 0.0 0.34 11.4 0.0 1.6 2 0 0 2 2 2 0 Siderophore-interacting protein Spectrin PF00435.21 PIK33749.1 - 8.9e-05 22.9 2.3 0.0024 18.4 0.5 2.7 2 1 0 2 2 2 1 Spectrin repeat MID_pPIWI_RE PF18157.1 PIK33749.1 - 0.035 14.4 1.1 0.082 13.2 1.1 1.7 1 0 0 1 1 1 0 MID domain of pPIWI_RE DUF3818 PF12825.7 PIK33749.1 - 0.38 9.7 2.6 2.3 7.2 2.1 1.9 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) MscS_porin PF12795.7 PIK33749.1 - 0.98 8.9 9.6 0.27 10.7 4.7 2.4 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain Adhes-Ig_like PF09085.10 PIK33751.1 - 0.031 14.4 0.0 0.036 14.2 0.0 1.1 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like AF-4 PF05110.13 PIK33754.1 - 0.022 12.9 12.6 0.024 12.8 12.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM219A PF15260.6 PIK33754.1 - 0.081 13.3 2.4 0.11 12.8 2.4 1.3 1 0 0 1 1 1 0 Protein family FAM219A Macoilin PF09726.9 PIK33754.1 - 0.37 9.3 10.4 0.45 9.0 10.4 1.0 1 0 0 1 1 1 0 Macoilin family HEXIM PF15313.6 PIK33754.1 - 3 8.0 5.2 8 6.6 5.2 1.7 1 1 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein HSP70 PF00012.20 PIK33755.1 - 7e-240 797.3 15.9 6.1e-239 794.2 15.9 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK33755.1 - 1e-12 47.6 0.1 2.9e-12 46.1 0.1 1.7 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 PIK33755.1 - 3.8e-05 23.5 0.0 7.2e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 PIK33755.1 - 0.0042 17.5 0.9 0.026 15.0 0.0 2.7 2 2 0 2 2 2 1 Cell division protein FtsA PBP1_TM PF14812.6 PIK33756.1 - 0.0029 18.0 1.3 0.0072 16.7 1.3 1.6 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4358 PF14270.6 PIK33757.1 - 0.0023 18.2 1.1 0.0023 18.2 1.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4358) CENP-H PF05837.12 PIK33757.1 - 0.036 14.5 2.9 0.051 14.0 2.9 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) NACHT PF05729.12 PIK33758.1 - 2.8e-07 30.6 0.0 1.5e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 NACHT domain KdpD PF02702.17 PIK33758.1 - 0.00035 20.1 0.1 0.00068 19.2 0.1 1.4 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain Pkinase PF00069.25 PIK33759.1 - 6.9e-45 153.5 0.3 8.4e-24 84.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK33759.1 - 3.1e-30 105.3 0.0 7.7e-17 61.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Ig_3 PF13927.6 PIK33761.1 - 1.3e-10 41.8 0.1 0.00052 20.6 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK33761.1 - 1.4e-07 31.7 0.4 0.16 12.3 0.0 3.3 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK33761.1 - 2.6e-07 30.6 0.0 0.008 16.2 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK33761.1 - 1.5e-05 25.0 0.3 1.8 8.8 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK33761.1 - 1.7e-05 24.8 0.0 3.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK33761.1 - 0.00079 19.6 1.8 0.01 16.0 0.5 3.0 2 2 1 3 3 3 1 Immunoglobulin V-set domain BiPBP_C PF06832.12 PIK33761.1 - 0.04 14.0 0.0 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 PIK33761.1 - 0.048 13.9 2.4 0.71 10.2 0.2 3.0 3 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK33761.1 - 0.12 12.0 0.1 0.67 9.6 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Lebercilin PF15619.6 PIK33762.1 - 0.0052 16.5 23.3 0.026 14.2 7.9 2.0 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease Cytochrom_B562 PF07361.11 PIK33762.1 - 0.0082 16.8 11.5 0.35 11.6 2.2 2.0 1 1 1 2 2 2 2 Cytochrome b562 Spc7 PF08317.11 PIK33762.1 - 0.011 14.6 22.3 0.013 14.4 22.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ERM PF00769.19 PIK33762.1 - 0.019 14.8 28.0 0.02 14.7 28.0 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Laminin_II PF06009.12 PIK33762.1 - 0.019 15.0 5.9 0.019 15.0 5.9 1.9 1 1 1 2 2 2 0 Laminin Domain II DUF4201 PF13870.6 PIK33762.1 - 0.019 14.7 23.2 0.011 15.5 21.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Prefoldin_2 PF01920.20 PIK33762.1 - 0.034 14.1 29.2 0.59 10.1 13.0 2.1 1 1 1 2 2 2 0 Prefoldin subunit GAS PF13851.6 PIK33762.1 - 0.042 13.2 26.6 0.036 13.4 24.6 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Occludin_ELL PF07303.13 PIK33762.1 - 0.042 14.6 12.8 0.06 14.1 12.8 1.3 1 0 0 1 1 1 0 Occludin homology domain Beta-lactamase2 PF13354.6 PIK33762.1 - 0.065 12.8 1.7 0.37 10.4 0.2 2.4 1 1 2 3 3 3 0 Beta-lactamase enzyme family Sec20 PF03908.13 PIK33762.1 - 0.095 12.6 9.2 0.62 10.0 1.1 2.1 1 1 1 2 2 2 0 Sec20 IFT57 PF10498.9 PIK33762.1 - 0.1 11.5 19.1 0.58 9.1 6.8 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 NPV_P10 PF05531.12 PIK33762.1 - 0.13 12.7 8.6 15 6.1 8.6 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Tup_N PF08581.10 PIK33762.1 - 0.14 12.4 22.1 1.8 8.9 3.6 2.4 1 1 1 2 2 2 0 Tup N-terminal DUF1664 PF07889.12 PIK33762.1 - 0.15 12.1 10.7 0.2 11.7 10.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) BEX PF04538.12 PIK33762.1 - 0.28 11.8 14.2 1.8 9.2 2.0 2.4 1 1 1 2 2 2 0 Brain expressed X-linked like family DHR10 PF18595.1 PIK33762.1 - 0.29 11.2 28.9 0.24 11.5 19.9 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4200 PF13863.6 PIK33762.1 - 0.3 11.5 27.0 0.79 10.1 27.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Phage_HK97_TLTM PF06120.11 PIK33762.1 - 0.34 10.1 12.7 0.84 8.8 12.5 1.7 1 1 0 1 1 1 0 Tail length tape measure protein Uds1 PF15456.6 PIK33762.1 - 0.36 11.0 16.6 0.72 10.0 8.3 2.1 1 1 1 2 2 2 0 Up-regulated During Septation YjcZ PF13990.6 PIK33762.1 - 0.38 10.1 5.4 0.41 10.0 5.4 1.0 1 0 0 1 1 1 0 YjcZ-like protein ADIP PF11559.8 PIK33762.1 - 0.39 10.8 23.8 0.17 11.9 8.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CREPT PF16566.5 PIK33762.1 - 0.42 10.8 18.1 3.2 7.9 18.1 2.0 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour KxDL PF10241.9 PIK33762.1 - 0.51 10.7 15.0 1.3 9.3 14.9 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein WDCP PF15390.6 PIK33762.1 - 0.51 8.7 9.4 0.56 8.5 9.4 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Tweety PF04906.13 PIK33762.1 - 0.54 8.9 3.9 0.72 8.5 3.9 1.3 1 1 0 1 1 1 0 Tweety FadA PF09403.10 PIK33762.1 - 0.72 10.4 26.9 1.8 9.1 9.0 2.1 1 1 1 2 2 2 0 Adhesion protein FadA Phage_GP20 PF06810.11 PIK33762.1 - 0.74 9.6 24.6 13 5.6 23.7 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 TMPIT PF07851.13 PIK33762.1 - 0.77 9.0 17.6 0.88 8.8 17.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Golgin_A5 PF09787.9 PIK33762.1 - 0.8 9.1 23.0 0.99 8.8 23.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF641 PF04859.12 PIK33762.1 - 0.8 10.0 20.6 2.8 8.3 6.8 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 PIK33762.1 - 0.83 8.9 14.8 1.1 8.6 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran_CTD PF16326.5 PIK33762.1 - 0.87 9.9 24.4 0.14 12.4 18.1 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain COG2 PF06148.11 PIK33762.1 - 0.92 9.6 12.0 0.77 9.8 8.3 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Lip_prot_lig_C PF10437.9 PIK33762.1 - 0.94 9.5 8.0 0.73 9.9 1.6 2.5 1 1 2 3 3 3 0 Bacterial lipoate protein ligase C-terminus Prefoldin PF02996.17 PIK33762.1 - 1.1 9.1 17.9 1.8 8.5 2.0 2.5 1 1 1 2 2 2 0 Prefoldin subunit DUF3584 PF12128.8 PIK33762.1 - 1.2 6.5 19.1 1.4 6.3 19.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Borrelia_P83 PF05262.11 PIK33762.1 - 1.4 7.3 18.7 1.7 7.1 18.7 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1910 PF08928.10 PIK33762.1 - 1.4 8.9 11.4 3.4 7.7 6.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) CHDCT2 PF08074.11 PIK33762.1 - 1.9 8.7 8.1 2 8.6 8.1 1.0 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain PRKG1_interact PF15898.5 PIK33762.1 - 2 9.4 24.9 4.3 8.3 19.0 2.7 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4315 PF14193.6 PIK33762.1 - 2 8.5 24.1 0.1 12.7 2.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4315) Allexi_40kDa PF05549.11 PIK33762.1 - 2 7.9 11.4 1.1 8.7 8.3 1.7 1 1 1 2 2 2 0 Allexivirus 40kDa protein CENP-H PF05837.12 PIK33762.1 - 2.2 8.7 19.6 4.2 7.8 19.5 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) V_ATPase_I PF01496.19 PIK33762.1 - 2.3 6.0 13.3 2.5 5.9 13.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 PIK33762.1 - 2.4 6.6 20.5 3.7 6.1 20.5 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A ARGLU PF15346.6 PIK33762.1 - 2.6 7.9 28.2 0.16 11.8 20.0 1.9 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 Exonuc_VII_L PF02601.15 PIK33762.1 - 2.7 7.5 16.1 2.7 7.5 16.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec8_exocyst PF04048.14 PIK33762.1 - 2.8 7.8 14.3 0.88 9.5 3.4 2.0 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain SlyX PF04102.12 PIK33762.1 - 3.3 8.4 20.0 2.3 8.9 1.2 2.2 1 1 1 2 2 2 0 SlyX DUF4337 PF14235.6 PIK33762.1 - 3.4 7.8 19.4 0.47 10.5 8.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Lge1 PF11488.8 PIK33762.1 - 3.4 7.9 25.4 7.9 6.7 7.0 2.7 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF948 PF06103.11 PIK33762.1 - 3.4 8.0 4.8 14 6.0 4.8 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.11 PIK33762.1 - 3.5 7.9 23.2 9 6.6 7.8 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4446 PF14584.6 PIK33762.1 - 3.7 7.5 16.7 4.8 7.2 10.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Atg14 PF10186.9 PIK33762.1 - 3.7 6.5 20.0 4.3 6.3 20.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 PIK33762.1 - 4.3 6.1 15.0 4.6 6.0 15.0 1.0 1 0 0 1 1 1 0 Vacuolar protein sorting 38 DUF2203 PF09969.9 PIK33762.1 - 5.1 7.8 10.8 15 6.4 10.8 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF724 PF05266.14 PIK33762.1 - 5.6 6.7 21.7 24 4.7 20.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF724) EMP24_GP25L PF01105.24 PIK33762.1 - 5.8 6.8 17.4 2.9 7.8 2.8 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD HIP1_clath_bdg PF16515.5 PIK33762.1 - 6.5 7.4 26.5 12 6.6 13.7 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PCRF PF03462.18 PIK33762.1 - 6.9 6.5 17.0 7.9 6.3 17.0 1.0 1 0 0 1 1 1 0 PCRF domain HTH_37 PF13744.6 PIK33762.1 - 7.4 6.6 11.5 1.2 9.1 4.7 2.3 1 1 2 3 3 3 0 Helix-turn-helix domain OmpH PF03938.14 PIK33762.1 - 8.2 6.8 28.8 22 5.4 28.8 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Phage_GPO PF05929.11 PIK33762.1 - 8.5 5.9 17.5 76 2.8 17.5 1.9 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Com_YlbF PF06133.11 PIK33762.1 - 9.6 6.9 23.6 20 5.9 22.6 1.9 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Pkinase_Tyr PF07714.17 PIK33764.1 - 3.5e-05 23.2 0.0 4.5e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK33764.1 - 4.9e-05 22.8 0.0 7.2e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Hs1pro-1_N PF07231.12 PIK33765.1 - 0.018 14.8 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Hs1pro-1 N-terminus Bcl-2 PF00452.19 PIK33768.1 - 0.0046 17.6 0.1 0.01 16.5 0.1 1.5 1 1 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family DUF29 PF01724.16 PIK33768.1 - 0.062 13.5 0.8 0.092 13.0 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF29 BID PF06393.11 PIK33768.1 - 0.062 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 BH3 interacting domain (BID) fn3 PF00041.21 PIK33769.1 - 1.8e-06 28.2 0.3 8.2e-05 22.9 0.0 2.6 2 0 0 2 2 2 1 Fibronectin type III domain Zn_peptidase_2 PF04298.12 PIK33769.1 - 0.017 14.6 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase CARD_2 PF16739.5 PIK33770.1 - 9.5e-14 51.2 0.2 2e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 Caspase recruitment domain MgtE_N PF03448.17 PIK33770.1 - 0.027 15.1 0.3 0.027 15.1 0.3 1.9 2 0 0 2 2 2 0 MgtE intracellular N domain 7tm_2 PF00002.24 PIK33771.1 - 1.1e-24 87.1 17.1 1.5e-24 86.6 17.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK33771.1 - 1.9e-09 37.9 9.1 3.7e-09 37.0 9.1 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.21 PIK33772.1 - 6.1e-34 117.5 25.2 1.2e-33 116.6 25.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK33772.1 - 2.7e-10 40.4 21.0 2.7e-10 40.4 21.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 PIK33772.1 - 7.6e-08 32.4 18.9 7.6e-08 32.4 18.9 1.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 PIK33772.1 - 1.3e-06 28.1 23.5 1.6e-06 27.7 23.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Holin_9 PF16936.5 PIK33772.1 - 0.25 11.5 7.2 9.6 6.4 3.6 2.9 2 0 0 2 2 2 0 Putative holin FA_desaturase PF00487.24 PIK33772.1 - 3.5 7.4 6.1 1.5 8.6 1.8 2.3 1 1 2 3 3 3 0 Fatty acid desaturase GTP-bdg_M PF16360.5 PIK33773.1 - 0.38 11.4 4.3 0.48 11.0 0.2 2.6 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Gamma_PGA_hydro PF05908.11 PIK33773.1 - 0.47 9.8 3.0 0.6 9.5 1.0 2.0 1 1 1 2 2 2 0 Poly-gamma-glutamate hydrolase Endonuc_Holl PF10107.9 PIK33773.1 - 0.8 9.5 6.6 86 2.9 6.6 2.3 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Retrotrans_gag PF03732.17 PIK33774.1 - 1.3e-06 28.6 0.7 2.6e-06 27.6 0.1 1.8 2 0 0 2 2 2 1 Retrotransposon gag protein HBS1_N PF08938.10 PIK33774.1 - 0.14 12.5 0.9 0.31 11.4 0.9 1.5 1 0 0 1 1 1 0 HBS1 N-terminus FMN_dh PF01070.18 PIK33775.1 - 1.1e-16 60.8 0.0 1.2e-16 60.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Ago_N_1 PF18351.1 PIK33775.1 - 0.039 14.4 0.0 0.05 14.0 0.0 1.1 1 0 0 1 1 1 0 Fungal Argonaute N-terminal domain FMN_dh PF01070.18 PIK33776.1 - 4.2e-76 256.2 0.5 5e-76 256.0 0.5 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK33776.1 - 1.5e-07 30.8 3.6 1.3e-05 24.4 2.5 2.9 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK33776.1 - 0.00045 19.5 0.1 0.00064 19.0 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 PIK33776.1 - 0.0021 17.6 0.3 0.041 13.4 0.1 2.5 2 1 0 2 2 2 1 Histidine biosynthesis protein NMO PF03060.15 PIK33776.1 - 0.0033 16.8 0.2 0.0051 16.2 0.2 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase G3P_antiterm PF04309.12 PIK33776.1 - 0.024 14.1 1.1 4.4 6.7 0.0 3.5 3 1 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator PHP PF02811.19 PIK33776.1 - 0.038 14.3 0.0 1.9 8.7 0.0 2.2 2 0 0 2 2 2 0 PHP domain Herpes_LAMP2 PF06126.11 PIK33779.1 - 0.11 11.0 2.2 0.15 10.7 2.2 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 RVT_1 PF00078.27 PIK33780.1 - 4.9e-08 32.7 0.0 6.3e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK33781.1 - 2.1e-07 30.7 15.8 0.00048 20.1 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK33781.1 - 0.00037 20.3 8.1 0.073 12.9 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK33781.1 - 0.015 15.3 16.0 0.19 11.7 1.3 3.7 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK33781.1 - 0.015 15.0 11.1 3.6 7.4 0.4 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK33781.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK33781.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger TUG-UBL1 PF11470.8 PIK33782.1 - 5.4e-06 26.5 0.0 1.2e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 TUG ubiquitin-like domain SMYLE_N PF18615.1 PIK33782.1 - 0.24 10.9 5.3 0.31 10.6 5.3 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Hid1 PF12722.7 PIK33782.1 - 3.2 5.8 5.7 3.8 5.5 5.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UBX PF00789.20 PIK33783.1 - 1.3e-10 41.4 0.1 3.1e-10 40.1 0.1 1.6 1 0 0 1 1 1 1 UBX domain BCAS2 PF05700.11 PIK33783.1 - 0.14 11.9 3.2 0.29 10.8 3.2 1.5 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) THAP PF05485.12 PIK33784.1 - 5.6e-06 27.2 0.2 1.7e-05 25.7 0.2 1.9 1 0 0 1 1 1 1 THAP domain zf-C2H2_11 PF16622.5 PIK33784.1 - 0.043 13.6 0.6 0.081 12.7 0.6 1.5 1 0 0 1 1 1 0 zinc-finger C2H2-type SMN PF06003.12 PIK33784.1 - 0.14 11.4 4.3 0.29 10.3 4.3 1.6 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) TSP_1 PF00090.19 PIK33785.1 - 7.7e-56 186.1 101.0 4.7e-16 58.7 10.0 7.4 7 0 0 7 7 7 7 Thrombospondin type 1 domain Laminin_G_2 PF02210.24 PIK33785.1 - 3.6e-14 53.4 0.0 2.4e-06 28.2 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK33785.1 - 1.2e-09 38.5 0.0 0.0014 18.9 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Exo70 PF03081.15 PIK33786.1 - 1.5e-69 234.9 17.6 1e-35 123.6 0.9 3.0 2 1 1 3 3 3 2 Exo70 exocyst complex subunit Sec34 PF04136.15 PIK33786.1 - 0.0081 16.1 6.7 0.046 13.6 4.5 2.7 2 0 0 2 2 2 1 Sec34-like family Syntaxin-6_N PF09177.11 PIK33786.1 - 0.25 11.9 3.7 2 9.0 2.3 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal TACC_C PF05010.14 PIK33786.1 - 0.29 10.9 11.9 0.038 13.8 5.3 2.7 3 0 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Gal4_dimer PF03902.13 PIK33786.1 - 0.36 11.0 3.6 14 5.9 2.1 3.6 2 1 0 2 2 2 0 Gal4-like dimerisation domain Laminin_II PF06009.12 PIK33786.1 - 0.51 10.4 4.0 1.7 8.7 4.0 2.0 1 1 0 1 1 1 0 Laminin Domain II P4Ha_N PF08336.11 PIK33786.1 - 1.1 9.3 9.1 12 5.9 0.3 3.0 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF1664 PF07889.12 PIK33786.1 - 1.1 9.3 4.4 3.3 7.8 3.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 PIK33786.1 - 1.4 8.4 5.5 0.43 10.1 2.4 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Hormone_recep PF00104.30 PIK33787.1 - 1e-13 51.3 0.1 1.7e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor P5CR_dimer PF14748.6 PIK33789.1 - 1e-16 61.0 0.0 1.3e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 PIK33790.1 - 2.6e-07 31.1 0.2 3e-07 30.9 0.2 1.1 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DUF2543 PF10820.8 PIK33791.1 - 0.092 12.9 0.6 1.5 9.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2543) SAC3_GANP PF03399.16 PIK33792.1 - 1.3e-28 100.3 5.2 8.6e-27 94.3 5.2 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 PIK33792.1 - 7.9e-11 42.1 0.7 1.3e-10 41.5 0.2 1.5 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family COX5A PF02284.16 PIK33792.1 - 0.02 14.9 0.3 0.072 13.1 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va C2-set_2 PF08205.12 PIK33793.1 - 8.5e-05 22.6 0.5 0.13 12.3 0.0 2.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK33793.1 - 0.0013 19.0 1.4 0.33 11.3 0.0 3.2 2 2 1 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK33793.1 - 0.0029 18.2 0.7 15 6.2 0.3 3.6 2 2 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK33793.1 - 0.012 15.8 0.5 16 5.7 0.0 3.5 3 1 1 4 4 4 0 Immunoglobulin domain fn3 PF00041.21 PIK33795.1 - 1.9e-08 34.5 4.2 2.1e-05 24.8 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK33795.1 - 0.00097 19.7 1.5 0.055 14.0 0.0 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF4998 PF16389.5 PIK33795.1 - 0.0058 16.2 0.9 0.14 11.7 0.9 2.2 1 1 1 2 2 2 2 Domain of unknown function GPI-anchored PF10342.9 PIK33795.1 - 0.03 15.1 1.1 0.03 15.1 1.1 2.6 3 0 0 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SEC-C PF02810.15 PIK33795.1 - 0.22 11.5 10.8 52 3.9 0.1 4.7 4 0 0 4 4 4 0 SEC-C motif CCDC53 PF10152.9 PIK33797.1 - 8e-43 146.5 2.5 6.3e-42 143.6 2.5 2.0 1 1 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF3671 PF12420.8 PIK33797.1 - 0.018 15.1 0.1 0.026 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function TPP_enzyme_N PF02776.18 PIK33798.1 - 1.1e-47 161.9 0.0 2.6e-46 157.3 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 PIK33798.1 - 1.2e-31 109.3 0.0 2e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 PIK33798.1 - 5.2e-17 62.1 0.0 1.1e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 PIK33798.1 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Rad50_zn_hook PF04423.14 PIK33798.1 - 1.5 8.7 3.6 3.2 7.7 3.6 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif Retrotrans_gag PF03732.17 PIK33799.1 - 3.5e-07 30.4 0.7 4.9e-07 29.9 0.1 1.5 2 0 0 2 2 2 1 Retrotransposon gag protein RVT_1 PF00078.27 PIK33800.1 - 1.5e-31 109.6 0.1 2.5e-31 108.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK33800.1 - 0.0067 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) DSPc PF00782.20 PIK33801.1 - 7.4e-24 84.1 0.0 1e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 PIK33801.1 - 0.039 14.3 0.0 0.062 13.6 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase PF00102.27 PIK33801.1 - 0.096 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ly49 PF08391.10 PIK33802.1 - 0.012 16.0 2.8 0.018 15.4 2.8 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region CcmD PF04995.14 PIK33802.1 - 0.038 14.1 0.8 0.068 13.3 0.1 1.9 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) O-antigen_lig PF13425.6 PIK33802.1 - 0.26 10.0 0.5 0.29 9.9 0.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4574 PF15141.6 PIK33802.1 - 0.89 9.5 5.9 0.81 9.6 4.1 1.9 1 1 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DUF5401 PF17380.2 PIK33802.1 - 8.1 4.4 17.4 11 3.9 17.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Baculo_PEP_C PF04513.12 PIK33803.1 - 0.34 10.9 3.2 0.3 11.1 0.2 2.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fibrinogen_C PF00147.18 PIK33804.1 - 2.4e-38 132.1 2.2 2.7e-38 132.0 2.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Flo11 PF10182.9 PIK33804.1 - 0.018 15.2 0.1 0.029 14.5 0.1 1.3 1 0 0 1 1 1 0 Flo11 domain Fibrinogen_C PF00147.18 PIK33805.1 - 7.7e-41 140.3 0.5 9.9e-41 140.0 0.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PAP2 PF01569.21 PIK33806.1 - 4e-31 107.6 0.8 2.5e-30 105.0 0.9 1.9 2 0 0 2 2 2 1 PAP2 superfamily ANAPC10 PF03256.16 PIK33807.1 - 3.6e-72 241.9 0.1 4.1e-72 241.7 0.1 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK33807.1 - 0.00054 20.1 0.1 0.00082 19.5 0.1 1.3 1 1 0 1 1 1 1 F5/8 type C domain PITH PF06201.13 PIK33807.1 - 0.0018 18.5 0.4 0.012 15.8 0.1 1.9 1 1 1 2 2 2 1 PITH domain XRCC1_N PF01834.16 PIK33807.1 - 0.024 14.6 0.0 0.36 10.8 0.0 2.0 1 1 1 2 2 2 0 XRCC1 N terminal domain AA_kinase PF00696.28 PIK33810.1 - 7.1e-28 97.8 0.0 8.4e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family zf-Di19 PF05605.12 PIK33811.1 - 0.0051 17.1 1.3 0.0081 16.4 0.2 1.9 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DUF4200 PF13863.6 PIK33811.1 - 0.0088 16.4 6.8 0.022 15.1 6.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) ATPase PF06745.13 PIK33811.1 - 0.018 14.4 0.6 0.029 13.7 0.6 1.3 1 0 0 1 1 1 0 KaiC RBD-FIP PF09457.10 PIK33811.1 - 0.019 14.9 3.8 0.08 12.9 0.0 2.6 2 0 0 2 2 2 0 FIP domain DUF5611 PF18446.1 PIK33811.1 - 0.023 15.6 0.3 0.039 14.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5611) EcoR124_C PF12008.8 PIK33811.1 - 0.026 14.2 1.3 0.04 13.6 1.3 1.2 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal V_ATPase_I PF01496.19 PIK33811.1 - 0.038 11.9 2.8 0.048 11.6 2.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNA_binding PF01877.17 PIK33811.1 - 0.065 13.5 1.2 0.27 11.5 0.4 2.2 1 1 1 2 2 2 0 RNA binding Cut12 PF11500.8 PIK33811.1 - 0.082 12.9 6.6 0.14 12.1 6.1 1.7 1 1 0 1 1 1 0 Spindle pole body formation-associated protein Noelin-1 PF12308.8 PIK33811.1 - 0.16 12.0 3.4 0.36 10.8 2.8 1.9 1 1 0 1 1 1 0 Neurogenesis glycoprotein FapA PF03961.13 PIK33811.1 - 0.16 10.6 3.4 0.068 11.8 1.4 1.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A IKKbetaNEMObind PF12179.8 PIK33811.1 - 0.42 10.7 3.0 3.5 7.8 0.2 3.4 3 0 0 3 3 3 0 I-kappa-kinase-beta NEMO binding domain OrsD PF12013.8 PIK33811.1 - 3.1 8.3 9.4 1.6 9.2 0.7 3.1 3 2 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D AAA_13 PF13166.6 PIK33811.1 - 4.1 5.9 9.8 8.6 4.9 9.8 1.6 1 1 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 PIK33811.1 - 8.4 5.9 16.4 52 3.2 16.4 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit F-box PF00646.33 PIK33812.1 - 9.6e-07 28.5 1.5 2.6e-06 27.1 1.5 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK33812.1 - 1.1e-05 25.2 0.5 1.1e-05 25.2 0.5 2.5 2 0 0 2 2 2 1 F-box-like zf-CCHC_6 PF15288.6 PIK33813.1 - 5e-10 39.0 2.3 5e-10 39.0 2.3 1.7 2 0 0 2 2 2 1 Zinc knuckle DUF3847 PF12958.7 PIK33813.1 - 0.21 11.7 11.8 0.22 11.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3847) zf-CCHC PF00098.23 PIK33813.1 - 0.77 10.0 4.7 1.9 8.7 4.7 1.7 1 1 0 1 1 1 0 Zinc knuckle Osteoregulin PF07175.11 PIK33813.1 - 4.8 7.4 7.8 0.64 10.2 0.1 2.5 3 0 0 3 3 3 0 Osteoregulin Bromodomain PF00439.25 PIK33814.1 - 9.6e-10 38.4 0.0 2e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Bromodomain NLE PF08154.12 PIK33814.1 - 0.15 12.6 0.1 0.27 11.8 0.1 1.3 1 0 0 1 1 1 0 NLE (NUC135) domain Bromodomain PF00439.25 PIK33815.1 - 2.6e-10 40.2 0.0 5.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain APC_N_CC PF16689.5 PIK33815.1 - 0.018 15.1 0.2 0.032 14.3 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Spc7 PF08317.11 PIK33815.1 - 0.023 13.6 1.7 0.026 13.4 1.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein YecR PF13992.6 PIK33815.1 - 0.03 14.6 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 YecR-like lipoprotein Phage_GPO PF05929.11 PIK33815.1 - 0.06 13.0 1.2 0.083 12.5 1.2 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase GCP_N_terminal PF17681.1 PIK33815.1 - 0.09 12.4 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal ANAPC15 PF15243.6 PIK33815.1 - 0.3 11.5 6.7 0.46 10.9 6.7 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Peptidase_A17 PF05380.13 PIK33816.1 - 4.2e-55 186.2 0.0 9.5e-55 185.0 0.0 1.7 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF5641 PF18701.1 PIK33816.1 - 4.9e-21 74.7 4.1 1.5e-20 73.1 4.1 1.9 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DUF1759 PF03564.15 PIK33816.1 - 5.8e-12 45.8 0.8 1.4e-11 44.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) rve PF00665.26 PIK33816.1 - 4.1e-09 36.7 0.0 1.6e-08 34.8 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK33816.1 - 5.2e-07 29.7 1.2 5.2e-07 29.7 1.2 2.7 2 0 0 2 2 2 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK33816.1 - 0.0034 17.4 2.2 0.012 15.7 1.4 2.5 2 0 0 2 2 2 1 Zinc knuckle RVT_1 PF00078.27 PIK33816.1 - 0.0078 15.7 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DnaJ_CXXCXGXG PF00684.19 PIK33816.1 - 0.032 14.6 8.6 0.13 12.7 8.6 2.1 1 0 0 1 1 1 0 DnaJ central domain DUF848 PF05852.11 PIK33816.1 - 5.3 7.2 10.8 0.2 11.7 1.4 2.6 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) NKAIN PF05640.14 PIK33817.1 - 1.5e-31 109.2 3.8 1.8e-31 109.0 3.8 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Linker_histone PF00538.19 PIK33818.1 - 4.7e-21 74.9 0.7 4.7e-21 74.9 0.7 3.1 2 1 1 3 3 3 1 linker histone H1 and H5 family DUF2052 PF09747.9 PIK33818.1 - 1.1 9.4 9.8 1.4 9.0 9.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Pkinase_fungal PF17667.1 PIK33818.1 - 3.3 6.4 13.3 3.9 6.1 13.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase SLC12 PF03522.15 PIK33818.1 - 3.7 6.5 17.0 4.1 6.3 17.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 PIK33818.1 - 5.3 4.0 14.3 5.5 4.0 14.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 PIK33818.1 - 6.1 5.8 9.0 7.9 5.4 9.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein SAPS PF04499.15 PIK33818.1 - 6.6 5.4 11.0 7.4 5.2 11.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CRAL_TRIO PF00650.20 PIK33819.1 - 6.4e-08 32.5 0.1 2.2e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 PIK33819.1 - 7.9e-06 26.0 2.0 1.8e-05 24.8 2.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain TRAPPC-Trs85 PF12739.7 PIK33821.1 - 1.1e-68 232.1 7.6 6.1e-68 229.7 7.6 2.0 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC-Trs85 PF12739.7 PIK33822.1 - 1.3e-12 47.5 0.1 1.7e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Dr_adhesin PF12393.8 PIK33822.1 - 0.58 10.5 1.9 1.3 9.4 1.9 1.6 1 0 0 1 1 1 0 Dr family adhesin EF-hand_1 PF00036.32 PIK33823.1 - 2.6e-17 61.0 4.9 1.3e-05 24.4 1.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK33823.1 - 3e-15 54.7 3.3 3.4e-05 23.4 0.3 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 PIK33823.1 - 2.3e-13 49.0 5.1 7.3e-05 22.1 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 PIK33823.1 - 4e-11 43.2 3.3 3.7e-07 30.5 1.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK33823.1 - 1.3e-10 41.0 2.8 0.0021 17.9 0.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair Caleosin PF05042.13 PIK33823.1 - 0.00029 20.8 0.1 0.019 14.9 0.1 2.1 1 1 1 2 2 2 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 PIK33823.1 - 0.00037 20.8 0.8 1.2 9.5 0.1 2.9 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 PIK33823.1 - 0.0046 16.8 3.5 2.4 8.1 0.0 3.3 3 1 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 PIK33823.1 - 0.0084 16.3 0.2 2.5 8.4 0.1 2.5 2 1 0 2 2 2 2 Dockerin type I domain M PF02370.16 PIK33823.1 - 0.87 10.3 3.8 0.68 10.7 0.7 2.5 2 0 0 2 2 2 0 M protein repeat ASH PF15780.5 PIK33825.1 - 2.9e-05 24.2 0.0 0.022 15.0 0.0 3.2 2 1 1 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MYCBPAP PF14646.6 PIK33825.1 - 0.038 12.9 0.0 0.31 9.9 0.0 1.9 1 1 1 2 2 2 0 MYCBP-associated protein family ASH PF15780.5 PIK33826.1 - 9.7e-05 22.5 0.3 0.093 12.9 0.0 2.8 2 1 1 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 PIK33826.1 - 0.0017 18.5 0.1 0.75 10.0 0.0 2.5 2 0 0 2 2 2 2 Flagellar-associated PapD-like DUF1573 PF07610.11 PIK33826.1 - 0.011 15.8 0.0 0.57 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1573) ASH PF15780.5 PIK33827.1 - 0.0002 21.5 1.1 7.1 6.9 0.0 5.1 5 0 0 5 5 5 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin COesterase PF00135.28 PIK33828.1 - 1.9e-14 53.4 0.0 2.1e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family DUF3481 PF11980.8 PIK33829.1 - 0.053 13.2 0.1 0.07 12.8 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein TMEM208_SND2 PF05620.11 PIK33829.1 - 0.16 11.8 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Prominin PF05478.11 PIK33829.1 - 0.17 9.8 0.6 0.19 9.6 0.6 1.1 1 0 0 1 1 1 0 Prominin 7tm_1 PF00001.21 PIK33830.1 - 3.5e-24 85.6 8.4 4e-24 85.4 8.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK33830.1 - 0.021 14.4 11.3 0.024 14.2 11.3 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK33830.1 - 0.91 8.7 8.4 1 8.6 8.4 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw AP1AR PF15745.5 PIK33831.1 - 2.2e-24 86.5 4.8 2.5e-24 86.4 4.8 1.2 1 0 0 1 1 1 1 AP-1 complex-associated regulatory protein DUF4586 PF15239.6 PIK33832.1 - 3.4e-55 188.4 12.9 3.6e-42 145.6 8.2 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4586) TRM13 PF05206.14 PIK33833.1 - 3e-77 259.7 0.5 1.8e-42 145.7 0.4 2.1 2 0 0 2 2 2 2 Methyltransferase TRM13 DBP10CT PF08147.12 PIK33834.1 - 1.2e-15 57.5 7.4 1.2e-15 57.5 7.4 2.4 2 0 0 2 2 2 1 DBP10CT (NUC160) domain Acetyltransf_2 PF00797.17 PIK33836.1 - 1.7e-06 28.0 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 PIK33837.1 - 4.8e-05 23.3 0.0 7.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase Phtf-FEM1B_bdg PF12129.8 PIK33838.1 - 3.1e-45 153.8 0.5 4.6e-45 153.2 0.5 1.2 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor 2-oxoacid_dh PF00198.23 PIK33839.1 - 2e-53 181.2 0.0 2.4e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 PIK33839.1 - 1.3e-16 60.6 0.1 2.7e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 PIK33839.1 - 1.2e-08 34.6 0.0 3.3e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Mito_fiss_reg PF05308.11 PIK33839.1 - 4.7 7.2 8.3 7.1 6.6 8.3 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator RRM_1 PF00076.22 PIK33840.1 - 3.2e-16 58.9 0.0 5.9e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK33840.1 - 4.7e-06 26.2 0.0 5.7e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3791 PF12668.7 PIK33840.1 - 0.034 14.2 0.1 1.6 8.8 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3791) Ank_2 PF12796.7 PIK33841.1 - 3.3e-07 30.8 0.8 1.5e-06 28.7 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK33841.1 - 1e-06 28.9 1.1 0.0012 19.1 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK33841.1 - 0.00016 21.9 0.1 1.1 10.1 0.0 3.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 PIK33841.1 - 0.0056 17.1 0.1 17 6.1 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 PIK33841.1 - 0.013 16.1 0.0 0.036 14.7 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Mic1 PF07035.12 PIK33841.1 - 0.21 11.3 7.3 0.39 10.4 0.9 2.8 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like RYDR_ITPR PF01365.21 PIK33841.1 - 0.91 8.9 7.2 0.41 10.0 0.1 3.2 2 2 0 2 2 2 0 RIH domain Arm PF00514.23 PIK33841.1 - 1.2 9.3 8.8 2 8.6 0.3 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF4147 PF13660.6 PIK33843.1 - 2.6e-72 243.1 1.6 4.3e-72 242.4 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 PIK33843.1 - 2.8e-34 117.6 1.2 5.6e-34 116.6 1.2 1.5 1 0 0 1 1 1 1 MOFRL family WD40 PF00400.32 PIK33844.1 - 7.2e-14 52.0 0.9 9.7e-05 23.1 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK33844.1 - 2.5e-08 34.1 0.0 0.021 15.1 0.0 3.7 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Arylsulfotran_2 PF14269.6 PIK33844.1 - 0.063 12.6 0.1 0.092 12.1 0.1 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Retrotrans_gag PF03732.17 PIK33845.1 - 3.6e-12 46.4 0.3 6.3e-12 45.6 0.3 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein gag-asp_proteas PF13975.6 PIK33845.1 - 0.00016 22.2 0.0 0.00032 21.2 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK33845.1 - 0.00036 21.1 0.0 0.0012 19.4 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 PIK33845.1 - 0.09 12.9 0.2 0.19 11.9 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle MLVIN_C PF18697.1 PIK33846.1 - 0.087 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RT_RNaseH_2 PF17919.1 PIK33847.1 - 4.5e-33 113.3 0.0 8.8e-33 112.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33847.1 - 9.2e-33 112.7 0.0 1.9e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33847.1 - 2.9e-28 98.9 0.2 5e-28 98.1 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK33847.1 - 3.3e-19 68.8 0.3 7.5e-19 67.6 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK33847.1 - 4.1e-07 30.1 0.8 1.1e-06 28.8 0.8 1.8 1 0 0 1 1 1 1 H2C2 zinc finger zf-trcl PF13451.6 PIK33847.1 - 1.7 8.6 5.6 0.27 11.2 0.7 2.2 3 0 0 3 3 3 0 Probable zinc-ribbon domain NAPRTase_N PF17767.1 PIK33848.1 - 1.8e-37 128.5 0.0 6e-37 126.8 0.0 1.9 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase PF04095.16 PIK33848.1 - 2e-09 37.4 0.0 0.00024 20.8 0.0 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_C PF17956.1 PIK33848.1 - 5.4e-08 33.2 0.0 1.2e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain QRPTase_N PF02749.16 PIK33848.1 - 0.0021 18.1 0.0 0.011 15.8 0.0 2.1 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain zf-RING_9 PF13901.6 PIK33849.1 - 1.9e-64 217.5 23.4 1.7e-63 214.4 12.3 2.3 2 0 0 2 2 2 2 Putative zinc-RING and/or ribbon C1_1 PF00130.22 PIK33849.1 - 3.8e-08 33.1 37.5 2.8e-07 30.3 6.9 4.9 3 2 2 5 5 5 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK33849.1 - 1.9e-05 24.9 31.2 7.9e-05 22.9 3.1 5.3 4 1 0 4 4 4 2 C1 domain Prok-RING_1 PF14446.6 PIK33849.1 - 0.0012 18.7 4.1 0.0012 18.7 4.1 3.4 3 2 0 3 3 3 2 Prokaryotic RING finger family 1 PHD_3 PF13922.6 PIK33849.1 - 0.0021 18.4 1.7 0.0021 18.4 1.7 2.9 2 0 0 2 2 2 1 PHD domain of transcriptional enhancer, Asx zf-RING_2 PF13639.6 PIK33849.1 - 0.033 14.5 7.7 0.033 14.5 7.7 3.9 4 1 0 4 4 4 0 Ring finger domain DUF3420 PF11900.8 PIK33849.1 - 0.16 12.1 2.9 0.13 12.5 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) T6SS_VipA PF05591.12 PIK33849.1 - 0.41 10.4 2.6 3.7 7.4 0.3 2.6 2 1 1 3 3 3 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 ADK_lid PF05191.14 PIK33849.1 - 0.44 10.6 11.5 0.39 10.7 2.1 4.1 3 0 0 3 3 3 0 Adenylate kinase, active site lid EF-hand_1 PF00036.32 PIK33850.1 - 2.7e-10 39.0 0.4 0.0001 21.6 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK33850.1 - 1.3e-08 35.1 0.5 5.7e-05 23.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK33850.1 - 2.5e-08 33.2 0.3 0.0012 18.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK33850.1 - 0.0045 16.4 0.5 2.2 7.9 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK33850.1 - 0.0071 16.2 0.3 0.28 11.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 PIK33850.1 - 0.093 12.7 0.8 1.4 8.9 0.1 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand B277 PF17623.2 PIK33851.1 - 5.6 6.0 5.9 0.76 8.8 1.9 1.5 2 0 0 2 2 2 0 Domain of unknown function Raftlin PF15250.6 PIK33853.1 - 0.32 9.7 0.0 0.32 9.7 0.0 2.8 2 1 0 2 2 2 0 Raftlin Ras PF00071.22 PIK33854.1 - 1.2e-32 112.8 0.1 1.4e-32 112.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK33854.1 - 1.1e-11 45.0 0.0 1.6e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK33854.1 - 6.4e-06 25.8 0.0 7.2e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK33854.1 - 9.6e-05 21.9 0.1 0.00012 21.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 PIK33854.1 - 0.006 16.4 0.0 0.0072 16.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SDA1 PF05285.12 PIK33854.1 - 0.62 9.4 13.7 0.73 9.2 13.7 1.1 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 PIK33854.1 - 2.3 7.6 10.9 2.8 7.3 10.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 PIK33854.1 - 3.7 5.6 11.4 4 5.5 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family SH3_9 PF14604.6 PIK33855.1 - 8.2e-14 51.2 0.1 1.7e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK33855.1 - 0.00016 21.2 0.0 0.00039 20.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PID PF00640.23 PIK33856.1 - 2.8e-10 40.4 0.0 2.9e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) CSTF2_hinge PF14327.6 PIK33857.1 - 2.1e-28 98.6 3.0 4.8e-28 97.4 3.0 1.6 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 PIK33857.1 - 2.2e-25 88.2 0.0 3.9e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK33857.1 - 0.0027 17.8 0.0 0.0068 16.5 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif RRM_Rrp7 PF17799.1 PIK33857.1 - 0.029 14.2 0.0 0.064 13.0 0.0 1.7 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 PIK33857.1 - 0.075 13.3 0.0 0.49 10.6 0.0 2.1 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CSTF_C PF14304.6 PIK33858.1 - 3.5e-10 39.3 0.3 7.3e-10 38.3 0.3 1.5 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal Ferric_reduct PF01794.19 PIK33859.1 - 9.3e-21 74.2 2.4 9.3e-21 74.2 2.4 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 PIK33859.1 - 1.2e-19 70.4 0.0 2.6e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 PIK33859.1 - 2e-05 24.7 0.2 7.4e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 PIK33859.1 - 0.025 14.9 0.0 0.054 13.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Ni_hydr_CYTB PF01292.20 PIK33859.1 - 0.034 13.7 3.2 0.13 11.9 3.2 2.0 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Pyr_redox_2 PF07992.14 PIK33860.1 - 8.9e-31 107.2 0.2 4.3e-18 65.6 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 PIK33860.1 - 5.2e-08 32.7 0.2 1.8e-07 31.0 0.2 1.9 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 PIK33860.1 - 0.00034 21.1 1.7 0.22 12.1 0.2 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK33860.1 - 0.0011 19.0 0.1 3.9 7.4 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 PIK33860.1 - 0.0044 16.2 0.1 2.3 7.3 0.1 2.3 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 PIK33860.1 - 0.011 14.8 0.7 2.4 7.2 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 PIK33860.1 - 0.014 14.7 1.5 1.9 7.6 0.2 3.1 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK33860.1 - 0.014 15.0 0.3 0.1 12.1 0.2 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK33860.1 - 0.11 11.6 1.3 2.4 7.1 0.2 2.8 3 0 0 3 3 3 0 FAD binding domain SIMPL PF04402.14 PIK33861.1 - 1.6e-08 35.2 0.0 1.9e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) SCO1-SenC PF02630.14 PIK33861.1 - 0.0093 15.9 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 SCO1/SenC Jagunal PF07086.12 PIK33862.1 - 2.2e-17 63.8 0.0 3.1e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis HYR PF02494.16 PIK33863.1 - 3.7e-10 40.0 0.7 1.1e-09 38.5 0.7 1.8 1 0 0 1 1 1 1 HYR domain Ras PF00071.22 PIK33864.1 - 5.1e-56 188.7 1.8 7.3e-56 188.2 1.8 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK33864.1 - 3.1e-34 117.8 0.7 6.4e-34 116.8 0.7 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK33864.1 - 2.4e-17 62.9 0.1 2.4e-17 62.9 0.1 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK33864.1 - 1.9e-10 40.5 0.3 3e-10 39.9 0.3 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK33864.1 - 1.5e-08 34.7 0.3 3.9e-08 33.4 0.1 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK33864.1 - 6.2e-06 25.9 1.1 3.2e-05 23.6 1.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK33864.1 - 1.8e-05 24.7 0.3 0.031 14.2 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 PIK33864.1 - 0.00011 21.7 0.2 0.00021 20.8 0.1 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 PIK33864.1 - 0.0078 16.6 0.0 0.022 15.2 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 PIK33864.1 - 0.033 13.7 0.3 0.07 12.7 0.3 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B CdhD PF03599.16 PIK33864.1 - 0.12 11.1 0.9 0.22 10.2 0.9 1.4 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit TIR_2 PF13676.6 PIK33864.1 - 0.12 13.0 0.3 0.4 11.3 0.1 2.1 2 1 0 2 2 2 0 TIR domain Macoilin PF09726.9 PIK33865.1 - 0.069 11.7 21.7 0.086 11.4 21.7 1.2 1 0 0 1 1 1 0 Macoilin family Effector_1 PF04518.12 PIK33865.1 - 0.099 11.7 6.8 0.12 11.5 6.8 1.2 1 0 0 1 1 1 0 Effector from type III secretion system Fumble PF03630.14 PIK33865.1 - 0.51 9.5 4.3 0.53 9.4 3.8 1.3 1 1 0 1 1 1 0 Fumble FUSC PF04632.12 PIK33865.1 - 0.63 8.5 5.6 0.81 8.1 5.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Laminin_II PF06009.12 PIK33865.1 - 1 9.4 14.7 0.52 10.3 11.0 2.0 1 1 1 2 2 2 0 Laminin Domain II Atg14 PF10186.9 PIK33865.1 - 2.1 7.3 22.4 2.8 6.9 22.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RasGAP_C PF03836.15 PIK33865.1 - 2.2 8.5 20.7 0.18 11.9 7.8 2.6 1 1 1 2 2 2 0 RasGAP C-terminus LptF_LptG PF03739.14 PIK33865.1 - 3 6.6 4.1 3.5 6.4 4.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Exonuc_VII_L PF02601.15 PIK33865.1 - 6.2 6.3 18.7 7.9 5.9 18.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EF-hand_7 PF13499.6 PIK33866.1 - 2.1e-15 56.9 3.0 9.6e-09 35.6 0.3 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK33866.1 - 1.5e-08 33.9 2.4 5.4e-05 22.8 0.6 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK33866.1 - 4.2e-08 32.2 4.1 2.4e-05 23.5 0.4 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK33866.1 - 0.00043 20.1 1.2 0.004 17.0 0.5 2.5 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK33866.1 - 0.00076 18.9 1.5 0.0011 18.3 0.3 1.9 2 0 0 2 2 2 1 EF hand zf-CCHC PF00098.23 PIK33867.1 - 0.00017 21.5 10.8 0.077 13.1 2.0 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK33867.1 - 0.00085 19.0 8.8 0.059 13.1 1.4 2.5 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK33867.1 - 0.018 14.9 7.2 0.26 11.1 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle CLIP1_ZNF PF16641.5 PIK33867.1 - 0.33 10.9 0.2 0.33 10.9 0.2 2.6 2 0 0 2 2 2 0 CLIP1 zinc knuckle Fibrinogen_C PF00147.18 PIK33868.1 - 3.1e-46 157.9 4.8 4.8e-46 157.3 4.8 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK33868.1 - 5.6e-06 26.2 16.9 5.6e-06 26.2 16.9 3.6 1 1 3 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK33868.1 - 9e-06 25.8 13.0 9e-06 25.8 13.0 3.6 3 0 0 3 3 3 1 EGF domain TIL PF01826.17 PIK33868.1 - 5.1e-05 23.4 10.6 5.1e-05 23.4 10.6 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.7 PIK33868.1 - 0.0045 17.6 2.6 0.0045 17.6 2.6 4.9 5 1 0 5 5 5 1 Human growth factor-like EGF cEGF PF12662.7 PIK33868.1 - 0.0059 16.5 19.4 0.1 12.5 5.7 4.1 3 1 0 3 3 3 2 Complement Clr-like EGF-like EGF PF00008.27 PIK33868.1 - 5.2 7.5 35.2 0.16 12.3 10.9 3.6 3 1 0 3 3 3 0 EGF-like domain Ets PF00178.22 PIK33872.1 - 1.4e-32 111.9 3.8 7.7e-32 109.6 1.6 2.6 2 1 0 2 2 2 1 Ets-domain GABP-alpha PF11620.8 PIK33872.1 - 1.7e-28 98.6 0.8 3e-28 97.8 0.8 1.4 1 0 0 1 1 1 1 GA-binding protein alpha chain SAM_PNT PF02198.16 PIK33872.1 - 3.7e-13 49.3 0.1 3.7e-13 49.3 0.1 2.3 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain LRR_8 PF13855.6 PIK33873.1 - 1.3e-32 111.4 31.4 7.9e-17 60.8 3.5 5.3 2 2 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK33873.1 - 2.9e-21 75.2 33.5 4.3e-06 27.0 3.2 6.5 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK33873.1 - 8.6e-17 61.3 2.3 7.5e-11 42.1 0.9 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) I-set PF07679.16 PIK33873.1 - 9.4e-11 41.6 0.0 1.9e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33873.1 - 3.2e-10 40.5 0.0 6.7e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 PIK33873.1 - 4.7e-08 32.7 5.8 1.5e-05 24.6 1.1 2.9 1 1 4 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 PIK33873.1 - 1.3e-07 31.1 23.8 0.23 12.1 0.5 8.8 7 2 0 7 7 7 2 Leucine Rich Repeat ig PF00047.25 PIK33873.1 - 1.7e-07 31.3 0.0 3.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK33873.1 - 7.9e-07 29.3 0.0 1.9e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_6 PF13516.6 PIK33873.1 - 5.3e-06 26.1 25.6 1.4 9.2 0.7 8.3 8 0 0 8 8 8 3 Leucine Rich repeat Ig_6 PF18452.1 PIK33873.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Baculo_ODV-E27 PF05314.11 PIK33873.1 - 0.034 13.3 0.1 0.061 12.5 0.1 1.3 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 LRRNT PF01462.18 PIK33873.1 - 0.046 13.4 7.0 0.067 12.9 2.5 3.0 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain DUF3087 PF11286.8 PIK33873.1 - 0.068 12.6 0.3 0.13 11.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) V-set PF07686.17 PIK33873.1 - 0.1 12.8 0.1 0.37 11.0 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin V-set domain TRAM_LAG1_CLN8 PF03798.16 PIK33874.1 - 1e-21 77.6 16.1 1e-21 77.6 16.1 1.4 2 0 0 2 2 2 1 TLC domain PHO4 PF01384.20 PIK33874.1 - 0.46 9.5 4.1 0.63 9.0 4.1 1.3 1 0 0 1 1 1 0 Phosphate transporter family mRNA_cap_enzyme PF01331.19 PIK33875.1 - 2e-43 148.5 3.0 1.4e-42 145.8 0.7 2.2 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 PIK33875.1 - 4.4e-21 75.5 0.1 1.1e-20 74.3 0.1 1.7 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.20 PIK33875.1 - 5.6e-09 35.9 0.6 1.3e-08 34.8 0.1 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK33875.1 - 0.0052 16.4 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase UPF0061 PF02696.14 PIK33876.1 - 3e-116 389.0 0.1 3.9e-116 388.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family ELO PF01151.18 PIK33878.1 - 1.3e-57 195.2 23.0 1.9e-49 168.4 16.4 2.0 2 0 0 2 2 2 2 GNS1/SUR4 family SecY PF00344.20 PIK33878.1 - 0.0094 15.2 0.1 0.027 13.7 0.0 1.8 2 0 0 2 2 2 1 SecY translocase AMP-binding PF00501.28 PIK33879.1 - 1.8e-62 211.3 0.0 2.6e-62 210.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK33879.1 - 3.1e-15 56.9 0.5 6.3e-15 55.9 0.5 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 PIK33880.1 - 3.7e-42 144.4 0.1 4.4e-42 144.2 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK33880.1 - 1.3e-40 139.9 0.1 1.5e-40 139.6 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 PIK33880.1 - 5.1e-18 65.2 0.3 5.5e-15 55.3 0.2 2.0 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 PIK33880.1 - 7.5e-18 64.5 0.2 9.4e-18 64.2 0.2 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 PIK33880.1 - 2.1e-12 46.8 0.0 2.7e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 PIK33880.1 - 1.1e-10 41.1 0.0 3.3e-10 39.6 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 PIK33880.1 - 1.2e-07 31.8 0.1 2e-07 31.1 0.1 1.3 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 PIK33880.1 - 5.1e-07 29.3 0.1 8.2e-07 28.7 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 PIK33880.1 - 7.2e-06 26.0 0.0 2.5e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK33880.1 - 0.00033 20.3 0.1 0.00042 20.0 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 PIK33880.1 - 0.014 15.7 0.1 0.025 14.9 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 PIK33880.1 - 0.024 14.2 0.1 0.081 12.5 0.0 1.9 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 PIK33880.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF5097 PF17020.5 PIK33880.1 - 0.039 14.3 0.0 0.077 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) TrkA_N PF02254.18 PIK33880.1 - 0.051 13.8 0.0 0.54 10.5 0.0 2.1 1 1 0 1 1 1 0 TrkA-N domain Methyltransf_31 PF13847.6 PIK33880.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain zf-CCHC PF00098.23 PIK33881.1 - 2.3e-08 33.7 9.2 0.00048 20.1 0.2 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK33881.1 - 0.015 15.0 11.5 3.6 7.4 0.3 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK33881.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK33881.1 - 0.017 14.9 0.9 0.017 14.9 0.9 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK33881.1 - 0.022 14.7 14.4 0.16 11.9 1.0 3.8 3 1 1 4 4 4 0 Zinc knuckle RRM_7 PF16367.5 PIK33881.1 - 0.046 13.9 0.0 0.096 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif zf-CCHC_6 PF15288.6 PIK33881.1 - 0.29 11.0 15.3 0.11 12.3 3.3 2.9 3 0 0 3 3 3 0 Zinc knuckle zinc-ribbons_6 PF07191.12 PIK33881.1 - 0.37 10.8 6.4 0.42 10.6 2.2 2.2 1 1 1 2 2 2 0 zinc-ribbons Acyl_transf_1 PF00698.21 PIK33882.1 - 1e-13 51.5 0.1 1.3e-13 51.1 0.1 1.1 1 0 0 1 1 1 1 Acyl transferase domain Bombinin PF05298.11 PIK33883.1 - 0.097 12.4 0.1 0.11 12.2 0.1 1.2 1 1 0 1 1 1 0 Bombinin Arm PF00514.23 PIK33884.1 - 1.2e-10 41.1 12.3 0.0014 18.6 0.3 6.4 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK33884.1 - 1.9e-06 28.2 6.3 0.047 14.2 0.7 4.2 4 2 0 4 4 4 3 HEAT-like repeat HEAT PF02985.22 PIK33884.1 - 0.02 15.1 3.6 3.6 8.1 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat Adaptin_N PF01602.20 PIK33884.1 - 0.12 10.9 0.5 0.16 10.5 0.5 1.5 1 1 0 1 1 1 0 Adaptin N terminal region Arm PF00514.23 PIK33885.1 - 3.7e-29 99.8 11.3 4.5e-10 39.2 0.1 5.1 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK33885.1 - 1.5e-11 44.5 3.8 5.1e-06 26.9 0.2 3.3 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 PIK33885.1 - 3.2e-08 33.9 2.5 0.0072 16.7 0.3 2.5 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 PIK33885.1 - 7e-07 29.0 6.1 0.039 14.2 0.1 4.3 4 0 0 4 4 4 3 HEAT repeat V-ATPase_H_N PF03224.14 PIK33885.1 - 0.0011 18.3 0.2 0.0015 17.9 0.2 1.2 1 0 0 1 1 1 1 V-ATPase subunit H IFRD PF05004.13 PIK33885.1 - 0.024 13.7 0.5 1.1 8.3 0.3 2.1 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) UNC45-central PF11701.8 PIK33885.1 - 0.029 14.3 1.0 0.046 13.7 1.0 1.3 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central Arm_2 PF04826.13 PIK33885.1 - 0.035 13.6 0.5 0.12 11.9 0.2 1.9 1 1 1 2 2 2 0 Armadillo-like Peroxidase_ext PF11895.8 PIK33885.1 - 0.052 13.5 0.3 0.76 9.7 0.1 2.6 1 1 1 2 2 2 0 Fungal peroxidase extension region Cnd1 PF12717.7 PIK33885.1 - 0.096 12.7 0.7 4.2 7.4 0.1 2.2 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 MFS_1 PF07690.16 PIK33886.1 - 7.5e-37 127.1 42.1 7.6e-32 110.6 31.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK33886.1 - 4.6e-05 22.5 35.6 0.00067 18.6 6.8 3.7 2 2 1 3 3 3 3 Sugar (and other) transporter DUF4097 PF13349.6 PIK33887.1 - 3.3e-09 36.5 5.2 1.5e-08 34.3 5.2 1.9 1 1 0 1 1 1 1 Putative adhesin COesterase PF00135.28 PIK33888.1 - 3.8e-42 144.8 0.0 8e-33 114.1 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family CdhD PF03599.16 PIK33889.1 - 0.16 10.6 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit baeRF_family12 PF18856.1 PIK33889.1 - 0.52 10.9 2.6 0.65 10.6 1.6 1.6 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 Ion_trans PF00520.31 PIK33890.1 - 0.0014 18.0 10.0 0.11 11.7 2.1 2.2 2 0 0 2 2 2 2 Ion transport protein DUF4618 PF15397.6 PIK33891.1 - 4.2e-38 131.3 17.6 5.8e-38 130.8 17.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Vps23_core PF09454.10 PIK33891.1 - 0.0081 16.1 0.4 0.32 11.0 0.0 2.5 1 1 1 2 2 2 1 Vps23 core domain Endotoxin_N PF03945.14 PIK33891.1 - 0.046 13.4 0.3 0.093 12.4 0.1 1.5 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain ZU5 PF00791.20 PIK33892.1 - 2e-15 56.9 0.0 3.4e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK33893.1 - 7.1e-06 26.2 0.1 0.16 12.3 0.0 2.2 2 0 0 2 2 2 2 Death effector domain BORA_N PF15280.6 PIK33893.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein aurora borealis N-terminus SAM_2 PF07647.17 PIK33894.1 - 9.5e-13 48.1 0.4 1.2e-12 47.8 0.4 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK33894.1 - 2.3e-09 37.5 0.3 3.3e-09 37.0 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK33894.1 - 0.00014 21.7 0.1 0.00018 21.4 0.1 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 PIK33894.1 - 0.11 12.3 0.2 0.46 10.3 0.2 1.9 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Neugrin PF06413.11 PIK33895.1 - 2.7e-27 96.3 12.6 1.1e-26 94.3 10.0 2.4 1 1 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 PIK33895.1 - 9.9e-10 38.8 1.9 2.1e-09 37.7 1.9 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_11 PF08279.12 PIK33895.1 - 0.00022 21.1 0.1 0.00044 20.1 0.1 1.5 1 0 0 1 1 1 1 HTH domain CENP-B_N PF04218.13 PIK33895.1 - 0.0072 15.9 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF5415 PF17436.2 PIK33895.1 - 0.068 13.3 1.1 0.21 11.7 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5415) HTH_psq PF05225.16 PIK33895.1 - 0.091 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Linker_histone PF00538.19 PIK33895.1 - 0.17 12.3 2.4 0.17 12.3 0.2 2.2 3 0 0 3 3 3 0 linker histone H1 and H5 family DCP2 PF05026.13 PIK33896.1 - 1.5e-24 86.1 0.1 3.1e-24 85.1 0.1 1.6 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 PIK33896.1 - 1.2e-17 64.2 0.0 2.4e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Nop52 PF05997.12 PIK33896.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Nucleolar protein,Nop52 Ccdc124 PF06244.12 PIK33897.1 - 2.8e-40 137.9 7.5 2.8e-40 137.9 7.5 2.3 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 PIK33897.1 - 0.0013 19.1 0.1 0.0013 19.1 0.1 3.1 2 1 1 3 3 3 1 HMG (high mobility group) box Oxysterol_BP PF01237.18 PIK33897.1 - 4.3 6.1 13.8 5.1 5.8 13.3 1.4 1 1 0 1 1 1 0 Oxysterol-binding protein Zip PF02535.22 PIK33898.1 - 2.6e-53 181.4 0.1 3.7e-53 180.9 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter QueT PF06177.11 PIK33898.1 - 0.59 10.5 7.5 1.7 9.0 5.5 2.4 2 1 0 2 2 2 0 QueT transporter SLC35F PF06027.12 PIK33900.1 - 4.8e-68 229.9 6.5 1e-34 120.5 1.8 2.0 1 1 1 2 2 2 2 Solute carrier family 35 EamA PF00892.20 PIK33900.1 - 0.00011 22.4 1.9 0.00011 22.4 1.9 3.2 2 1 2 4 4 4 1 EamA-like transporter family Glucos_trans_II PF14264.6 PIK33900.1 - 0.0035 16.7 2.4 0.0053 16.1 2.4 1.2 1 0 0 1 1 1 1 Glucosyl transferase GtrII YtpI PF14007.6 PIK33900.1 - 0.076 13.2 0.6 0.27 11.4 0.3 2.0 1 1 0 1 1 1 0 YtpI-like protein Radical_SAM PF04055.21 PIK33901.1 - 1.2e-30 107.0 0.0 2.6e-30 106.0 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 PIK33901.1 - 4.1e-29 100.5 0.0 8.4e-29 99.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 PIK33901.1 - 1.4e-11 44.2 0.1 3.2e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 TRAM domain DUF2529 PF10740.9 PIK33901.1 - 0.059 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) DUF2152 PF10222.9 PIK33902.1 - 0.015 13.7 0.5 0.072 11.4 0.5 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) Glyco_hydro_65m PF03632.15 PIK33903.1 - 2.7e-44 151.6 0.0 4.1e-39 134.5 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Ephrin_rec_like PF07699.13 PIK33904.1 - 6e-05 22.7 22.4 0.0003 20.5 3.7 19.8 11 7 11 22 22 22 14 Putative ephrin-receptor like Plasmodium_HRP PF05403.11 PIK33905.1 - 1.4e-11 44.6 135.9 4.6e-08 33.1 72.0 2.0 1 1 1 2 2 2 2 Plasmodium histidine-rich protein (HRPII/III) Ephrin_rec_like PF07699.13 PIK33906.1 - 0.012 15.4 3.4 0.012 15.4 3.4 9.0 4 3 6 10 10 10 0 Putative ephrin-receptor like GalKase_gal_bdg PF10509.9 PIK33906.1 - 0.026 14.1 0.0 0.28 10.8 0.0 2.5 2 1 0 2 2 2 0 Galactokinase galactose-binding signature TNFR_c6 PF00020.18 PIK33906.1 - 0.46 10.9 62.4 0.49 10.8 2.4 9.4 6 3 2 8 8 8 0 TNFR/NGFR cysteine-rich region Pyr_redox_2 PF07992.14 PIK33907.1 - 0.011 14.9 0.0 0.012 14.9 0.0 1.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 7tm_1 PF00001.21 PIK33908.1 - 3.5e-52 177.3 20.3 5.4e-52 176.7 20.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK33908.1 - 3.2e-12 46.4 21.4 4.3e-12 46.0 21.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK33908.1 - 9.7e-05 22.2 16.8 0.0058 16.4 12.7 3.1 2 1 0 2 2 2 2 Olfactory receptor CH PF00307.31 PIK33909.1 - 1.3e-13 51.1 0.0 1.7e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 PIK33909.1 - 1.9e-10 40.1 4.3 1.9e-10 40.1 4.3 1.8 2 0 0 2 2 2 1 Calponin family repeat CDC24 PF06395.11 PIK33909.1 - 0.0029 17.8 0.0 0.0045 17.2 0.0 1.2 1 0 0 1 1 1 1 CDC24 Calponin Glyco_transf_29 PF00777.18 PIK33910.1 - 2.4e-54 184.6 1.2 7.1e-53 179.7 1.2 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) zf-C2H2_2 PF12756.7 PIK33911.1 - 9.5e-10 38.7 0.8 2.4e-09 37.4 0.8 1.7 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Neur_chan_LBD PF02931.23 PIK33913.1 - 6.3e-24 84.6 3.8 6.9e-24 84.5 3.8 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF5402 PF17393.2 PIK33913.1 - 0.0075 16.2 0.0 0.0086 16.0 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5402) EutB PF06751.11 PIK33915.1 - 0.013 14.4 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine ammonia lyase large subunit (EutB) RVT_1 PF00078.27 PIK33915.1 - 0.013 15.0 0.5 0.029 13.9 0.1 1.7 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Homeobox_KN PF05920.11 PIK33915.1 - 0.17 11.8 0.3 0.44 10.5 0.3 1.8 1 1 0 1 1 1 0 Homeobox KN domain RVT_1 PF00078.27 PIK33916.1 - 2.9e-17 62.9 0.0 4.4e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK33916.1 - 6.5e-16 58.2 0.0 1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33916.1 - 0.00063 20.0 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33917.1 - 0.0002 21.0 0.0 0.00044 19.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RSB_motif PF16294.5 PIK33917.1 - 0.019 15.2 0.4 0.046 14.0 0.4 1.6 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif DUF515 PF04415.12 PIK33917.1 - 0.084 11.3 1.4 0.2 10.0 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Kinesin PF00225.23 PIK33918.1 - 2.9e-30 105.4 0.1 3.5e-30 105.1 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK33918.1 - 7.8e-23 81.1 0.1 1e-22 80.7 0.1 1.0 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 PIK33918.1 - 0.019 14.2 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase Myb_DNA-bind_6 PF13921.6 PIK33920.1 - 3.2e-16 59.3 1.3 5.6e-16 58.6 1.3 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 PIK33920.1 - 3.7e-15 55.8 1.2 3.7e-15 55.8 1.2 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK33920.1 - 0.0036 17.2 0.5 0.0047 16.8 0.5 1.3 1 0 0 1 1 1 1 Myb DNA-binding like SLIDE PF09111.10 PIK33920.1 - 0.069 13.2 0.1 0.11 12.5 0.1 1.5 1 1 0 1 1 1 0 SLIDE Cmyb_C PF09316.10 PIK33921.1 - 6.8e-06 25.9 10.4 0.00011 21.9 2.7 2.6 2 0 0 2 2 2 2 C-myb, C-terminal RVT_1 PF00078.27 PIK33922.1 - 4.7e-12 45.9 0.0 6.3e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK33923.1 - 3.2e-32 110.5 0.2 1.1e-31 108.8 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK33923.1 - 3.3e-27 94.8 0.0 7.9e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK33923.1 - 8.3e-20 71.2 0.0 1.8e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK33923.1 - 1.2e-17 63.7 0.2 1.2e-17 63.7 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK33923.1 - 4.3e-09 36.6 0.1 2.2e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.6 PIK33923.1 - 0.00067 20.2 0.0 0.0017 18.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 PIK33923.1 - 0.0039 17.4 0.1 0.0039 17.4 0.1 2.0 2 0 0 2 2 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 PIK33923.1 - 0.009 16.6 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease PCC_BT PF18140.1 PIK33923.1 - 0.065 13.6 0.3 0.35 11.2 0.1 2.3 2 1 0 2 2 2 0 Propionyl-coenzyme A carboxylase BT domain Peptidase_A2E PF12382.8 PIK33923.1 - 0.13 12.3 0.1 8.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Retrotransposon peptidase RVP PF00077.20 PIK33923.1 - 0.16 12.3 0.1 0.91 9.9 0.0 2.4 3 0 0 3 3 3 0 Retroviral aspartyl protease RVT_1 PF00078.27 PIK33924.1 - 2.6e-20 72.9 0.3 5.5e-20 71.8 0.3 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_base_V PF04717.12 PIK33924.1 - 0.17 11.8 0.3 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 Type VI secretion system, phage-baseplate injector PLAT PF01477.23 PIK33925.1 - 2.7e-27 95.7 0.1 1.1e-19 71.2 0.1 2.1 2 0 0 2 2 2 2 PLAT/LH2 domain DUF2914 PF11141.8 PIK33925.1 - 0.054 13.2 0.4 0.14 11.9 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) AIG1 PF04548.16 PIK33927.1 - 8.1e-39 133.1 0.0 9.3e-39 133.0 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK33927.1 - 9.4e-10 38.6 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK33927.1 - 3.4e-06 27.2 0.6 0.062 13.4 0.0 2.3 1 1 1 2 2 2 2 Dynamin family IIGP PF05049.13 PIK33927.1 - 0.00045 19.4 0.0 0.00081 18.5 0.0 1.4 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 PIK33927.1 - 0.00054 20.3 0.0 0.00092 19.6 0.0 1.3 1 0 0 1 1 1 1 RNA helicase FeoB_N PF02421.18 PIK33927.1 - 0.0014 18.2 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK33927.1 - 0.0018 18.2 0.1 0.0043 17.0 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK33927.1 - 0.0072 16.9 0.1 0.0086 16.6 0.1 1.5 1 1 0 1 1 1 1 ABC transporter Guanylate_kin PF00625.21 PIK33927.1 - 0.035 13.8 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Guanylate kinase AAA_7 PF12775.7 PIK33927.1 - 0.037 13.5 0.0 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 PIK33927.1 - 0.042 13.6 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Septin PF00735.18 PIK33927.1 - 0.053 12.8 0.2 0.13 11.5 0.1 1.6 1 1 0 1 1 1 0 Septin Roc PF08477.13 PIK33927.1 - 0.056 13.7 0.2 0.11 12.7 0.1 1.8 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 PIK33927.1 - 0.086 13.1 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 PIK33927.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ras family DUF87 PF01935.17 PIK33927.1 - 0.2 11.7 2.7 0.29 11.2 0.6 2.2 2 1 1 3 3 3 0 Helicase HerA, central domain NACHT PF05729.12 PIK33928.1 - 8.8e-09 35.5 0.0 1.7e-08 34.6 0.0 1.4 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK33928.1 - 0.0023 18.2 0.0 0.0048 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK33928.1 - 0.0039 16.8 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK33928.1 - 0.07 12.4 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3368 PF11848.8 PIK33928.1 - 0.091 12.6 1.3 0.2 11.5 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) NACHT PF05729.12 PIK33929.1 - 3.9e-15 56.1 0.0 1.3e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 NACHT domain Nucleoside_tran PF01733.18 PIK33929.1 - 0.0096 15.3 0.8 0.021 14.2 0.2 1.9 2 0 0 2 2 2 1 Nucleoside transporter 7tm_1 PF00001.21 PIK33929.1 - 0.0099 15.2 0.0 0.03 13.7 0.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) AAA_22 PF13401.6 PIK33929.1 - 0.018 15.3 0.0 0.046 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK33929.1 - 0.029 13.9 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain 7tm_2 PF00002.24 PIK33929.1 - 0.038 13.3 0.4 0.038 13.3 0.4 2.0 2 0 0 2 2 2 0 7 transmembrane receptor (Secretin family) Shisa PF13908.6 PIK33929.1 - 0.22 11.8 0.9 0.39 10.9 0.9 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator GPI2 PF06432.11 PIK33929.1 - 0.37 10.2 2.9 0.7 9.3 0.1 2.3 3 0 0 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase Peptidase_S49_N PF08496.10 PIK33929.1 - 8.2 6.5 7.4 0.81 9.7 0.7 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ig_3 PF13927.6 PIK33930.1 - 1.3e-07 32.1 0.5 0.1 13.2 0.0 4.8 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK33930.1 - 4.8e-07 29.9 0.1 0.0022 18.2 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK33930.1 - 0.00028 20.9 0.2 0.016 15.2 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK33930.1 - 0.039 14.3 7.4 0.41 11.0 0.1 4.9 4 1 1 5 5 5 0 Immunoglobulin domain DUF1533 PF07550.11 PIK33930.1 - 0.058 13.3 0.0 13 5.8 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1533) Exo_endo_phos_2 PF14529.6 PIK33932.1 - 2.4e-06 27.4 0.3 8.2e-06 25.7 0.3 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Fibrinogen_C PF00147.18 PIK33933.1 - 1.8e-25 90.1 3.0 1.9e-25 90.0 3.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK33933.1 - 0.046 13.6 3.8 0.078 12.8 3.8 1.3 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) Membr_traf_MHD PF10540.9 PIK33934.1 - 3.1e-41 141.0 3.0 2e-39 135.1 3.0 3.0 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 PIK33934.1 - 2.2e-31 108.2 8.9 1.2e-26 93.0 0.3 3.1 3 0 0 3 3 3 2 C2 domain DUF1041 PF06292.17 PIK33934.1 - 1.4e-21 76.8 0.0 5.7e-21 74.9 0.0 2.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.22 PIK33934.1 - 8.6e-11 41.6 6.0 1.6e-10 40.7 6.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) WD40 PF00400.32 PIK33935.1 - 0.0011 19.8 1.6 0.0086 16.9 1.0 2.6 3 0 0 3 3 3 1 WD domain, G-beta repeat ApbE PF02424.15 PIK33936.1 - 0.2 11.1 0.0 1.8 8.1 0.0 1.9 1 1 1 2 2 2 0 ApbE family LIX1 PF14954.6 PIK33937.1 - 4.1e-102 340.7 0.8 5.1e-102 340.4 0.8 1.0 1 0 0 1 1 1 1 Limb expression 1 SF3A2 PF16835.5 PIK33938.1 - 4.5e-08 33.3 0.0 7.9e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 PIK33938.1 - 2.7e-07 30.8 2.0 6.1e-07 29.6 2.0 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 PIK33938.1 - 0.1 12.2 3.2 0.16 11.5 3.2 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like zf-C2H2_jaz PF12171.8 PIK33938.1 - 8.8 6.8 6.3 14 6.2 4.6 2.2 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF3715 PF12509.8 PIK33939.1 - 0.091 12.8 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3715) DUF2635 PF10948.8 PIK33939.1 - 0.11 12.2 0.0 0.63 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2635) 7tm_1 PF00001.21 PIK33940.1 - 2.2e-19 69.8 18.3 1.5e-12 47.4 12.1 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) Herpes_US9 PF06072.11 PIK33940.1 - 0.072 13.0 2.1 0.15 11.9 0.3 2.5 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 fn3 PF00041.21 PIK33941.1 - 2.9e-20 72.4 0.1 5.8e-10 39.4 0.0 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK33941.1 - 2e-06 28.2 0.2 0.089 13.4 0.1 2.5 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK33941.1 - 0.013 15.8 0.0 2.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 PIK33941.1 - 0.07 13.3 0.0 4.4 7.5 0.0 2.3 2 1 0 2 2 2 0 Fibronectin type III domain DUF5581 PF17744.1 PIK33941.1 - 0.092 12.1 0.0 0.7 9.2 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5581) fn3 PF00041.21 PIK33942.1 - 4.4e-20 71.8 2.1 1.4e-07 31.8 0.1 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK33942.1 - 1.8e-05 25.2 6.7 0.19 12.3 0.0 3.1 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain AcetDehyd-dimer PF09290.11 PIK33942.1 - 0.0028 17.9 0.1 0.0048 17.1 0.1 1.3 1 0 0 1 1 1 1 Prokaryotic acetaldehyde dehydrogenase, dimerisation DUF4178 PF13785.6 PIK33942.1 - 0.086 13.0 1.0 0.15 12.1 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) CENP-B_dimeris PF09026.10 PIK33942.1 - 0.61 10.5 9.1 1 9.8 9.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 PIK33942.1 - 1.3 8.3 3.5 2 7.7 3.5 1.3 1 0 0 1 1 1 0 NOA36 protein LRR_8 PF13855.6 PIK33943.1 - 3.8e-27 93.8 30.2 1.2e-10 41.0 2.2 5.9 2 2 5 7 7 7 5 Leucine rich repeat LRR_5 PF13306.6 PIK33943.1 - 4.1e-10 39.7 10.6 4.9e-08 33.0 4.0 2.8 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK33943.1 - 4.7e-09 36.4 34.4 0.00052 20.4 2.2 7.4 3 2 4 7 7 7 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK33943.1 - 1.6e-05 24.5 6.8 1.6e-05 24.5 6.8 2.7 2 2 1 3 3 3 1 Leucine-rich repeat Shisa PF13908.6 PIK33943.1 - 0.011 16.1 0.6 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK33943.1 - 0.027 14.4 0.3 0.053 13.4 0.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family LRR_1 PF00560.33 PIK33943.1 - 0.034 14.7 20.2 7.7 7.5 0.0 6.7 6 0 0 6 6 6 0 Leucine Rich Repeat DUF2179 PF10035.9 PIK33943.1 - 0.061 13.1 0.0 17 5.2 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) Herpes_gE PF02480.16 PIK33943.1 - 0.07 11.9 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E RIFIN PF02009.16 PIK33943.1 - 0.16 11.9 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 Rifin Y_phosphatase PF00102.27 PIK33944.1 - 2e-18 66.8 0.1 2.2e-18 66.7 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Helo_like_N PF17111.5 PIK33944.1 - 0.076 12.4 0.1 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Glyco_hydro_16 PF00722.21 PIK33946.1 - 3.8e-17 62.3 0.4 7.7e-17 61.3 0.4 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 MGC-24 PF05283.11 PIK33946.1 - 3.3 8.2 8.1 6.9 7.1 8.1 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CBM39 PF15886.5 PIK33947.1 - 2.1e-21 75.9 0.3 4.9e-21 74.6 0.3 1.7 1 0 0 1 1 1 1 Carbohydrate binding domain (family 32) Glyco_hydro_16 PF00722.21 PIK33947.1 - 9e-16 57.8 0.0 1.8e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Rad1 PF02144.16 PIK33948.1 - 2.6e-32 112.0 0.6 2.8e-32 111.9 0.6 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad1 PF02144.16 PIK33949.1 - 2.4e-25 89.1 0.1 2.9e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PCNA_N PF00705.18 PIK33949.1 - 0.01 15.5 0.3 0.015 15.0 0.3 1.3 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain KR PF08659.10 PIK33949.1 - 0.021 14.8 0.1 0.025 14.5 0.1 1.1 1 0 0 1 1 1 0 KR domain RTC PF01137.21 PIK33950.1 - 2.2e-09 36.8 0.0 2.6e-09 36.6 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 PIK33951.1 - 4.7e-32 110.6 0.0 6.6e-32 110.1 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 PIK33951.1 - 8e-24 84.1 0.0 8.9e-24 83.9 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase GPHH PF16905.5 PIK33951.1 - 0.18 11.6 0.1 0.6 9.9 0.1 1.8 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated NDUFA12 PF05071.16 PIK33952.1 - 0.0021 18.9 1.3 0.0093 16.8 1.3 2.2 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Cyto_heme_lyase PF01265.17 PIK33953.1 - 0.00022 21.0 4.0 0.00027 20.7 4.0 1.2 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase UDPGT PF00201.18 PIK33954.1 - 6.6e-35 120.8 0.0 7.7e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Ras PF00071.22 PIK33955.1 - 1.5e-19 70.2 0.1 1.8e-19 69.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK33955.1 - 0.067 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Filament PF00038.21 PIK33956.1 - 0.029 14.0 5.2 0.042 13.4 5.2 1.4 1 0 0 1 1 1 0 Intermediate filament protein Phage_GPO PF05929.11 PIK33956.1 - 0.04 13.6 2.0 0.047 13.3 2.0 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ANAPC4 PF12896.7 PIK33956.1 - 0.04 13.4 1.5 0.11 11.9 0.7 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Prominin PF05478.11 PIK33956.1 - 0.047 11.7 0.7 0.056 11.4 0.7 1.2 1 0 0 1 1 1 0 Prominin Spc7 PF08317.11 PIK33956.1 - 0.058 12.3 6.6 0.081 11.8 6.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.12 PIK33956.1 - 0.069 13.6 5.8 0.084 13.3 5.2 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Atg14 PF10186.9 PIK33956.1 - 0.076 12.1 2.6 0.12 11.4 2.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 PIK33956.1 - 0.09 13.1 1.8 0.42 10.9 0.4 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein SLX9 PF15341.6 PIK33956.1 - 0.093 13.1 2.6 0.11 12.9 1.6 1.4 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF948 PF06103.11 PIK33956.1 - 0.12 12.7 2.7 3.3 8.0 0.4 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 PIK33956.1 - 0.14 12.2 3.0 0.31 11.1 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 PIK33956.1 - 0.31 10.3 4.8 0.33 10.2 4.1 1.4 1 1 0 1 1 1 0 TMPIT-like protein MRPL52 PF18699.1 PIK33956.1 - 0.43 10.8 5.2 0.29 11.3 2.9 1.9 2 0 0 2 2 2 0 Mitoribosomal protein mL52 bZIP_1 PF00170.21 PIK33956.1 - 0.67 10.1 8.3 0.71 10.0 0.1 3.1 3 1 1 4 4 4 0 bZIP transcription factor Occludin_ELL PF07303.13 PIK33956.1 - 0.83 10.4 5.4 1.7 9.4 1.5 2.5 2 1 0 2 2 2 0 Occludin homology domain YabA PF06156.13 PIK33956.1 - 0.92 10.2 5.3 0.47 11.1 0.6 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Arf PF00025.21 PIK33957.1 - 1.5e-08 34.3 0.0 3.2e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Peptidase_C1 PF00112.23 PIK33958.1 - 4.7e-47 160.9 2.6 8.6e-47 160.0 2.6 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK33958.1 - 1.3e-10 41.6 4.7 2e-10 40.9 4.7 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK33958.1 - 0.069 11.9 0.2 0.1 11.4 0.2 1.2 1 0 0 1 1 1 0 Peptidase C1-like family AsnC_trans_reg2 PF17805.1 PIK33959.1 - 0.071 13.3 0.3 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 AsnC-like ligand binding domain RIO1 PF01163.22 PIK33960.1 - 1.8e-70 236.4 0.3 3.4e-70 235.5 0.3 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK33960.1 - 0.00012 22.1 0.2 0.0005 20.1 0.1 1.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK33960.1 - 0.02 14.3 0.8 0.38 10.1 0.8 2.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK33960.1 - 0.028 13.2 8.6 0.056 12.2 7.4 2.2 1 1 0 1 1 1 0 Fungal protein kinase Trefoil PF00088.18 PIK33961.1 - 3.8e-28 97.1 37.8 2.7e-10 40.0 2.4 4.2 4 0 0 4 4 4 4 Trefoil (P-type) domain DUF1935 PF09149.10 PIK33961.1 - 0.0041 17.5 0.0 1.8 9.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1935) Ank_4 PF13637.6 PIK33962.1 - 6.1e-17 61.8 3.4 4.3e-10 39.9 0.1 3.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK33962.1 - 1.5e-13 50.7 2.0 1.1e-10 41.6 0.5 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK33962.1 - 7.2e-13 48.9 0.5 1.2e-11 45.0 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK33962.1 - 3e-11 43.2 7.7 1.8e-05 24.9 0.3 4.5 4 1 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK33962.1 - 1.7e-10 40.2 4.3 3.4e-06 27.0 0.1 4.6 5 1 0 5 5 5 2 Ankyrin repeat Maf_N PF08383.11 PIK33962.1 - 0.07 12.9 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 Maf N-terminal region MLVIN_C PF18697.1 PIK33963.1 - 0.051 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain BING4CT PF08149.11 PIK33964.1 - 0.009 15.8 0.1 0.069 13.0 0.0 2.1 2 0 0 2 2 2 1 BING4CT (NUC141) domain CD225 PF04505.12 PIK33965.1 - 1.5e-21 76.3 2.4 1.5e-21 76.3 2.4 1.8 2 0 0 2 2 2 1 Interferon-induced transmembrane protein Cut8 PF08559.10 PIK33966.1 - 0.0049 16.5 1.0 0.0065 16.1 1.0 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein DUF3530 PF12048.8 PIK33966.1 - 0.071 12.5 0.1 0.079 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) SH2 PF00017.24 PIK33968.1 - 4.3e-12 46.0 0.1 4.6e-12 45.9 0.1 1.0 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 PIK33968.1 - 0.015 14.7 0.0 0.015 14.7 0.0 1.0 1 0 0 1 1 1 0 SH2 domain I-set PF07679.16 PIK33969.1 - 1.6e-24 85.8 0.0 1.9e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33969.1 - 7.3e-18 65.0 0.0 1.2e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK33969.1 - 6.2e-14 51.9 0.0 8.6e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK33969.1 - 1.1e-12 48.1 0.0 1.5e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK33969.1 - 6.1e-08 32.8 0.1 8.7e-05 22.7 0.1 2.1 1 1 1 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK33969.1 - 0.0028 17.2 0.0 0.0092 15.5 0.0 1.8 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK33969.1 - 0.0096 16.0 0.0 0.019 15.0 0.0 1.6 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 PIK33969.1 - 0.045 13.8 0.0 0.067 13.2 0.0 1.4 1 1 0 1 1 1 0 C17orf99 Ig domain I-set PF07679.16 PIK33970.1 - 8e-05 22.6 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33970.1 - 0.013 16.1 0.0 0.046 14.3 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK33971.1 - 0.00017 21.6 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain I-set PF07679.16 PIK33972.1 - 3.2e-163 530.3 1.2 3.3e-23 81.6 0.0 11.1 12 0 0 12 12 11 9 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33972.1 - 4.3e-103 338.1 0.9 6.3e-15 55.5 0.0 10.5 11 0 0 11 11 11 8 Immunoglobulin domain fn3 PF00041.21 PIK33972.1 - 2.5e-97 319.4 16.8 1.1e-15 57.7 0.1 7.6 7 0 0 7 7 7 7 Fibronectin type III domain Pkinase PF00069.25 PIK33972.1 - 1.1e-70 238.1 0.1 1.6e-70 237.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain ig PF00047.25 PIK33972.1 - 1.7e-62 207.5 5.9 6.6e-13 48.6 0.0 9.0 9 0 0 9 9 8 8 Immunoglobulin domain Ig_2 PF13895.6 PIK33972.1 - 1.1e-57 192.4 0.8 2.7e-09 37.2 0.0 8.7 8 0 0 8 8 8 8 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK33972.1 - 1.1e-37 129.7 0.1 1.8e-37 129.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase V-set PF07686.17 PIK33972.1 - 4.7e-28 97.5 25.5 0.0019 18.3 0.0 14.6 9 7 0 9 9 9 7 Immunoglobulin V-set domain C1-set PF07654.15 PIK33972.1 - 7e-17 61.6 0.9 0.036 14.4 0.0 8.2 8 0 0 8 8 8 3 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 PIK33972.1 - 9.5e-15 54.7 0.1 0.042 14.1 0.0 8.0 8 0 0 8 8 8 3 Natural killer cell receptor 2B4 C2-set_2 PF08205.12 PIK33972.1 - 3.2e-14 52.8 2.7 0.14 12.2 0.0 7.4 8 0 0 8 8 7 4 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK33972.1 - 3.6e-14 53.1 1.7 0.39 11.3 0.0 8.7 7 0 0 7 7 7 3 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 PIK33972.1 - 3.9e-05 23.6 5.9 0.95 9.6 0.1 5.9 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK33972.1 - 6.4e-05 23.1 4.1 3.9 7.8 0.0 6.5 7 0 0 7 7 6 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 PIK33972.1 - 8.1e-05 22.6 0.0 1.5 8.9 0.0 5.0 5 1 0 5 5 5 1 C17orf99 Ig domain Kdo PF06293.14 PIK33972.1 - 0.00019 20.9 0.6 0.00036 20.0 0.6 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK33972.1 - 0.00033 19.5 0.0 0.00067 18.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 PIK33972.1 - 0.0056 16.3 1.1 0.012 15.2 1.1 1.5 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 PIK33972.1 - 0.0073 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF2369 PF10179.9 PIK33972.1 - 0.015 15.7 0.0 59 4.1 0.0 5.5 6 0 0 6 6 6 0 Uncharacterised conserved protein (DUF2369) PKD_3 PF16820.5 PIK33972.1 - 0.029 14.1 1.3 42 4.0 0.0 5.1 6 0 0 6 6 6 0 PKD-like domain V-set_CD47 PF08204.11 PIK33972.1 - 0.033 14.2 0.2 1.1 9.3 0.0 3.1 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain APH PF01636.23 PIK33972.1 - 0.071 13.0 0.2 1.4 8.8 0.2 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family fn3 PF00041.21 PIK33973.1 - 2.2e-51 172.1 7.6 2.7e-17 62.9 0.1 5.0 5 0 0 5 5 5 4 Fibronectin type III domain I-set PF07679.16 PIK33973.1 - 1.6e-18 66.5 0.0 3.9e-17 62.1 0.0 3.0 4 0 0 4 4 4 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK33973.1 - 1.2e-10 41.8 0.1 3.5e-09 37.1 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK33973.1 - 8.1e-06 26.3 7.2 0.095 13.3 0.0 4.6 5 2 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK33973.1 - 0.00016 21.8 0.3 0.14 12.3 0.0 3.5 3 1 0 3 3 3 1 Fibronectin type III domain Ig_2 PF13895.6 PIK33973.1 - 0.00017 21.8 0.1 0.00048 20.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK33973.1 - 0.00086 19.4 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK33973.1 - 0.0041 17.3 0.0 0.028 14.6 0.0 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain Y_Y_Y PF07495.13 PIK33973.1 - 0.053 13.5 0.1 0.6 10.1 0.0 2.8 3 0 0 3 3 3 0 Y_Y_Y domain fn3 PF00041.21 PIK33974.1 - 1e-113 371.9 23.9 7.9e-17 61.4 0.3 8.3 8 0 0 8 8 8 8 Fibronectin type III domain I-set PF07679.16 PIK33974.1 - 7.7e-26 90.0 0.9 3.3e-14 52.7 0.0 6.4 6 0 0 6 6 6 2 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 PIK33974.1 - 2.8e-18 66.2 15.0 0.0042 17.6 0.0 9.2 7 3 0 8 8 8 3 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK33974.1 - 1.9e-14 53.6 0.0 0.5 10.6 0.0 7.4 8 0 0 8 8 8 4 Fibronectin type III domain Ig_3 PF13927.6 PIK33974.1 - 6.4e-10 39.5 1.2 2.6e-05 24.7 0.0 4.9 5 0 0 5 5 5 2 Immunoglobulin domain GPI-anchored PF10342.9 PIK33974.1 - 5.7e-05 23.8 14.2 0.081 13.7 0.3 8.2 9 1 1 10 10 8 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family ig PF00047.25 PIK33974.1 - 0.00026 21.1 0.0 0.00026 21.1 0.0 3.3 4 0 0 4 4 4 1 Immunoglobulin domain Y_Y_Y PF07495.13 PIK33974.1 - 0.00027 20.9 0.1 4.2 7.4 0.0 4.8 4 0 0 4 4 4 1 Y_Y_Y domain Ig_2 PF13895.6 PIK33974.1 - 0.0033 17.7 0.0 0.093 13.1 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain Glyco_hydro_5_C PF18564.1 PIK33974.1 - 0.0047 17.4 0.3 0.12 12.9 0.1 3.5 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain DUF2393 PF09624.10 PIK33974.1 - 0.0061 16.6 0.3 13 5.8 0.0 3.9 5 0 0 5 5 4 0 Protein of unknown function (DUF2393) bMG6 PF17962.1 PIK33974.1 - 0.021 15.0 1.3 61 3.8 0.1 5.7 6 0 0 6 6 6 0 Bacterial macroglobulin domain 6 Collagen_bind_2 PF12904.7 PIK33974.1 - 0.026 14.5 0.3 4 7.5 0.0 3.8 4 0 0 4 4 4 0 Putative collagen-binding domain of a collagenase PhoD_N PF16655.5 PIK33974.1 - 0.065 13.8 0.6 37 4.9 0.0 5.0 8 0 0 8 8 6 0 PhoD-like phosphatase, N-terminal domain DUF756 PF05506.12 PIK33974.1 - 0.29 12.1 2.0 44 5.1 0.2 4.8 6 1 0 6 6 4 0 Domain of unknown function (DUF756) CRISPR_assoc PF08798.11 PIK33974.1 - 4.8 7.2 5.9 32 4.5 0.0 4.4 6 1 1 7 7 7 0 CRISPR associated protein He_PIG PF05345.12 PIK33974.1 - 5.1 7.4 15.4 7.6 6.8 2.1 6.0 7 1 0 7 7 7 0 Putative Ig domain Peptidase_M28 PF04389.17 PIK33975.1 - 3.9e-25 88.7 0.0 5.8e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 PIK33975.1 - 5.2e-06 26.3 0.0 1.7e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 T4BSS_DotH_IcmK PF12293.8 PIK33975.1 - 0.074 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion Codanin-1_C PF15296.6 PIK33976.1 - 2.2e-23 82.6 0.6 5.7e-23 81.3 0.0 2.1 2 0 0 2 2 2 1 Codanin-1 C-terminus 2-Hacid_dh_C PF02826.19 PIK33977.1 - 0.038 13.4 0.0 0.077 12.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Siva PF05458.12 PIK33978.1 - 4.1e-10 39.6 0.0 4.2e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Cd27 binding protein (Siva) DUF4939 PF16297.5 PIK33979.1 - 0.068 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) zf-Di19 PF05605.12 PIK33980.1 - 1.4e-06 28.5 3.0 0.00045 20.5 0.4 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK33980.1 - 1.2e-05 25.7 10.0 0.004 17.9 1.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK33980.1 - 0.0057 17.1 8.3 0.012 16.0 1.2 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type OrsD PF12013.8 PIK33980.1 - 0.029 14.8 1.7 4.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 PIK33980.1 - 0.038 13.8 1.4 0.038 13.8 1.4 2.5 2 1 0 2 2 2 0 C2H2-type zinc-finger domain Prok-RING_1 PF14446.6 PIK33980.1 - 0.054 13.4 0.9 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Actin_micro PF17003.5 PIK33980.1 - 0.06 12.5 1.2 0.095 11.9 1.2 1.3 1 0 0 1 1 1 0 Putative actin-like family Zn-C2H2_12 PF18112.1 PIK33980.1 - 0.074 13.5 1.8 0.76 10.3 0.2 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-LYAR PF08790.11 PIK33980.1 - 0.14 12.1 5.0 3.9 7.5 0.1 2.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-BED PF02892.15 PIK33980.1 - 0.23 11.5 7.0 0.87 9.7 0.2 2.5 2 0 0 2 2 2 0 BED zinc finger c-SKI_SMAD_bind PF08782.10 PIK33980.1 - 2.1 8.6 5.0 4.2 7.7 0.3 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain RVT_1 PF00078.27 PIK33981.1 - 8.3e-10 38.5 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK33981.1 - 2.3e-06 27.1 0.0 7.3e-05 22.3 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) Exo_endo_phos_2 PF14529.6 PIK33982.1 - 0.0046 16.8 0.0 0.19 11.6 0.0 2.4 1 1 1 2 2 2 1 Endonuclease-reverse transcriptase DUF1579 PF07617.11 PIK33982.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) RVT_1 PF00078.27 PIK33983.1 - 4.2e-15 55.9 0.1 4.9e-15 55.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flagellin_C PF00700.21 PIK33983.1 - 0.12 12.8 1.2 0.22 11.9 0.5 1.7 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region NACHT PF05729.12 PIK33984.1 - 1.7e-13 50.8 0.3 4.9e-13 49.3 0.1 1.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK33984.1 - 0.0011 19.2 0.2 0.0052 17.1 0.0 2.2 1 1 2 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK33984.1 - 0.002 18.5 0.0 0.0046 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 PIK33984.1 - 0.0029 17.6 0.0 0.008 16.1 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK33984.1 - 0.0083 16.7 4.5 0.035 14.6 4.4 2.1 1 1 0 1 1 1 1 ABC transporter TniB PF05621.11 PIK33984.1 - 0.015 14.7 0.0 0.1 12.0 0.0 2.3 2 1 1 3 3 3 0 Bacterial TniB protein AAA PF00004.29 PIK33984.1 - 0.027 14.9 0.7 0.12 12.8 0.1 2.4 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1086 PF06461.11 PIK33984.1 - 0.041 13.8 0.1 0.092 12.6 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) IstB_IS21 PF01695.17 PIK33984.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF87 PF01935.17 PIK33984.1 - 2.3 8.3 10.4 28 4.7 9.0 2.9 2 1 0 2 2 2 0 Helicase HerA, central domain Rpn3_C PF08375.11 PIK33985.1 - 6.5e-27 93.7 3.8 6.5e-27 93.7 3.8 2.5 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 PIK33985.1 - 2.6e-23 82.5 1.4 2e-22 79.7 0.0 2.9 3 0 0 3 3 3 1 PCI domain NACHT PF05729.12 PIK33986.1 - 2e-10 40.9 0.0 5.3e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK33986.1 - 3.1e-08 33.8 6.3 1.1e-05 25.6 0.0 4.9 5 0 0 5 5 5 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK33986.1 - 0.00035 21.1 0.6 0.0018 18.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain AAA_25 PF13481.6 PIK33986.1 - 0.0013 18.4 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain I-set PF07679.16 PIK33986.1 - 0.0084 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain AAA_29 PF13555.6 PIK33986.1 - 0.018 14.8 0.2 0.041 13.6 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma_reg_N PF13800.6 PIK33986.1 - 0.041 14.2 0.3 0.14 12.4 0.3 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMEM100 PF16311.5 PIK33986.1 - 0.098 12.2 0.2 0.23 11.1 0.2 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 AAA_16 PF13191.6 PIK33986.1 - 0.16 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_F PF01990.17 PIK33987.1 - 1.6e-30 105.2 0.0 2.1e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit ERCC4 PF02732.15 PIK33988.1 - 1.4e-12 48.1 0.1 1.4e-12 48.1 0.1 2.3 3 0 0 3 3 3 1 ERCC4 domain CUE PF02845.16 PIK33988.1 - 0.0011 18.6 0.1 0.0021 17.7 0.1 1.5 1 0 0 1 1 1 1 CUE domain SPRY PF00622.28 PIK33989.1 - 1.8e-13 50.7 1.4 2e-13 50.5 0.2 1.7 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.16 PIK33989.1 - 0.0002 21.6 0.1 0.00042 20.6 0.1 1.5 1 0 0 1 1 1 1 SOCS box PCNA_C PF02747.15 PIK33989.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain UNC45-central PF11701.8 PIK33990.1 - 0.0034 17.4 1.2 0.0069 16.4 1.2 1.4 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central Multi-haem_cyto PF13447.6 PIK33990.1 - 0.016 14.5 0.1 0.031 13.5 0.1 1.4 1 0 0 1 1 1 0 Seven times multi-haem cytochrome CxxCH Cadherin PF00028.17 PIK33992.1 - 1.4e-226 733.8 54.8 8.4e-19 67.8 0.2 17.4 17 0 0 17 17 17 17 Cadherin domain Cadherin_2 PF08266.12 PIK33992.1 - 6e-26 90.1 3.3 0.2 11.5 0.0 13.3 14 1 0 14 14 14 8 Cadherin-like Cadherin_3 PF16184.5 PIK33992.1 - 1.4e-17 63.7 48.0 2.5e-05 24.2 0.7 14.5 14 1 1 15 15 15 6 Cadherin-like Big_9 PF17963.1 PIK33992.1 - 0.011 16.5 1.9 0.011 16.5 1.9 14.4 14 2 1 15 15 15 0 Bacterial Ig domain TagA PF12561.8 PIK33992.1 - 0.03 14.7 0.0 0.14 12.6 0.0 2.3 2 1 0 2 2 2 0 ToxR activated gene A lipoprotein domain C2 PF00168.30 PIK33992.1 - 0.056 13.7 0.0 12 6.2 0.0 4.0 4 0 0 4 4 4 0 C2 domain He_PIG PF05345.12 PIK33992.1 - 0.39 10.9 19.6 8.2 6.7 0.1 8.6 10 0 0 10 10 10 0 Putative Ig domain PepSY PF03413.19 PIK33992.1 - 1.5 9.5 7.7 44 4.7 0.0 6.3 7 0 0 7 7 7 0 Peptidase propeptide and YPEB domain PI-PLC-Y PF00387.19 PIK33993.1 - 7.2e-42 142.4 2.6 1.9e-41 141.0 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF1154 PF06631.11 PIK33993.1 - 0.018 15.1 12.1 0.018 15.1 12.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) Prok-TraM PF09228.10 PIK33993.1 - 0.061 13.7 0.2 0.16 12.4 0.2 1.7 1 0 0 1 1 1 0 Prokaryotic Transcriptional repressor TraM PLC-beta_C PF08703.10 PIK33994.1 - 0.00018 21.6 31.1 0.00018 21.6 31.1 1.7 1 1 1 2 2 2 1 PLC-beta C terminal RVT_1 PF00078.27 PIK33996.1 - 2.7e-42 144.8 0.5 4.6e-42 144.0 0.2 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK33996.1 - 0.067 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Med18 protein Dor1 PF04124.12 PIK33997.1 - 0.096 11.4 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Dor1-like family RVT_1 PF00078.27 PIK33998.1 - 3.3e-20 72.6 0.0 6.3e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ALS2CR8 PF15299.6 PIK33999.1 - 9.4e-32 110.7 8.1 1.5e-31 110.0 8.1 1.3 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 MULE PF10551.9 PIK33999.1 - 6.9e-11 42.4 1.2 1.4e-10 41.4 0.2 2.0 2 0 0 2 2 2 1 MULE transposase domain Thiamine_BP PF01910.17 PIK33999.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Thiamine-binding protein RVT_1 PF00078.27 PIK34000.1 - 1.4e-18 67.2 0.0 1.7e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) T4-Gluco-transf PF09198.10 PIK34000.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase Metallophos_2 PF12850.7 PIK34002.1 - 3.3e-06 27.4 0.0 3.5e-06 27.3 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Rad9 PF04139.13 PIK34003.1 - 7.6e-67 225.4 0.1 1.9e-36 125.8 0.0 2.1 2 0 0 2 2 2 2 Rad9 NACHT PF05729.12 PIK34005.1 - 7.2e-22 78.1 0.0 1.1e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK34005.1 - 0.0015 18.2 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK34005.1 - 0.005 16.0 0.0 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK34005.1 - 0.006 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK34005.1 - 0.0096 15.3 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_29 PF13555.6 PIK34005.1 - 0.021 14.5 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 PIK34005.1 - 0.03 14.2 0.1 7 6.5 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain ABC_tran PF00005.27 PIK34005.1 - 0.061 13.8 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 PIK34005.1 - 0.08 13.3 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 PIK34005.1 - 0.091 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK34005.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sulfotransfer_2 PF03567.14 PIK34006.1 - 3.9e-07 30.2 0.9 5.6e-07 29.7 0.9 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK34006.1 - 0.0019 17.7 0.0 0.0091 15.5 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain TnsE_C PF18623.1 PIK34006.1 - 0.091 12.7 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 TnsE C-terminal domain 7tm_2 PF00002.24 PIK34007.1 - 2.4e-47 161.3 10.5 2.8e-47 161.1 10.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK34007.1 - 0.15 12.4 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 Hormone receptor domain Arm_vescicular PF18770.1 PIK34007.1 - 0.35 10.8 3.1 0.16 11.9 0.5 1.7 2 0 0 2 2 2 0 Armadillo tether-repeat of vescicular transport factor zf-H2C2_2 PF13465.6 PIK34008.1 - 1.4e-14 53.7 28.3 0.00011 22.4 0.2 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK34008.1 - 2e-12 46.8 35.7 0.0019 18.5 2.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK34008.1 - 2.1e-11 43.8 16.7 0.0085 16.4 0.2 4.4 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK34008.1 - 1.7e-10 40.9 22.4 0.0016 18.8 0.4 4.5 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 PIK34008.1 - 3.3e-10 39.9 30.2 0.0016 19.1 1.2 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK34008.1 - 0.00022 21.5 19.7 3.3 8.1 1.2 4.3 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK34008.1 - 0.001 18.8 1.5 0.001 18.8 1.5 3.1 3 0 0 3 3 3 1 zinc-finger C2H2-type Ta0938 PF11494.8 PIK34008.1 - 0.057 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Ta0938 zf-Sec23_Sec24 PF04810.15 PIK34008.1 - 0.073 13.1 6.4 1.5 8.9 0.3 2.6 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-LYAR PF08790.11 PIK34008.1 - 0.13 12.1 9.8 0.37 10.7 0.1 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Transglut_C PF00927.22 PIK34008.1 - 0.17 12.0 0.8 0.4 10.8 0.2 1.9 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain Elf1 PF05129.13 PIK34008.1 - 1.2 9.2 8.4 1.4 9.0 1.9 3.1 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like CLPTM1 PF05602.12 PIK34009.1 - 2.8e-81 273.7 2.8 4.3e-64 217.1 0.0 2.1 1 1 1 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) FEZ PF07763.13 PIK34011.1 - 3.4e-14 53.2 0.7 4.5e-14 52.8 0.7 1.1 1 0 0 1 1 1 1 FEZ-like protein VbhA PF18495.1 PIK34011.1 - 0.1 12.5 0.1 0.31 10.9 0.1 1.9 1 1 0 1 1 1 0 Antitoxin VbhA SnAPC_2_like PF11035.8 PIK34014.1 - 2.2e-08 34.7 1.8 2.2e-08 34.7 1.8 1.8 2 0 0 2 2 2 1 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Cornifin PF02389.15 PIK34014.1 - 0.0039 17.4 0.0 0.007 16.6 0.0 1.3 1 0 0 1 1 1 1 Cornifin (SPRR) family Carboxyl_trans PF01039.22 PIK34015.1 - 1.4e-18 66.9 0.0 1.8e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Exo_endo_phos_2 PF14529.6 PIK34016.1 - 2.1e-06 27.6 0.1 4.4e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK34016.1 - 0.1 12.1 0.4 0.28 10.6 0.2 1.8 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK34017.1 - 1.2e-30 106.7 0.1 1.6e-30 106.3 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TMEM154 PF15102.6 PIK34019.1 - 7.7e-05 22.6 0.1 9.3e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 TMEM154 protein family Saf_2TM PF18303.1 PIK34019.1 - 0.0016 18.0 0.1 0.002 17.7 0.1 1.1 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain DUF3139 PF11337.8 PIK34019.1 - 0.0041 17.7 0.2 0.0051 17.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3139) DUF872 PF05915.12 PIK34019.1 - 0.021 15.0 0.0 0.028 14.6 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF4834 PF16118.5 PIK34019.1 - 0.035 15.1 0.5 0.063 14.2 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Tetraspanin PF00335.20 PIK34019.1 - 0.044 13.5 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 Tetraspanin family Shisa PF13908.6 PIK34019.1 - 0.11 12.8 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK34019.1 - 0.12 13.3 0.1 0.16 12.9 0.1 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain C2-set_2 PF08205.12 PIK34020.1 - 0.0047 17.0 0.9 0.0092 16.0 0.3 1.8 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain CD225 PF04505.12 PIK34021.1 - 1.5e-23 82.7 1.9 2.3e-23 82.1 1.9 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Drf_FH1 PF06346.12 PIK34021.1 - 0.016 15.0 3.2 0.022 14.5 3.2 1.3 1 1 0 1 1 1 0 Formin Homology Region 1 DUF4190 PF13828.6 PIK34021.1 - 0.027 14.2 0.5 0.027 14.2 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) DUF1388 PF07142.12 PIK34021.1 - 0.22 11.5 2.5 5.4 7.1 0.8 2.3 1 1 1 2 2 2 0 Repeat of unknown function (DUF1388) Rrp44_S1 PF17215.3 PIK34022.1 - 0.046 13.7 0.1 0.67 9.9 0.1 2.2 2 0 0 2 2 2 0 S1 domain PAS_11 PF14598.6 PIK34023.1 - 2.3e-08 34.2 2.3 2.6e-07 30.8 0.0 3.1 2 1 1 3 3 3 1 PAS domain PAS_3 PF08447.12 PIK34023.1 - 6.8e-07 29.5 0.3 1.5e-06 28.4 0.3 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 PIK34024.1 - 1.3e-09 38.0 0.0 2.7e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 PAS fold PAS_11 PF14598.6 PIK34024.1 - 0.00033 20.7 0.2 1.2 9.3 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS_9 PF13426.7 PIK34024.1 - 0.0037 17.5 0.0 0.0095 16.2 0.0 1.7 1 1 0 1 1 1 1 PAS domain PAS_3 PF08447.12 PIK34024.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 PIK34024.1 - 0.057 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold Fibrinogen_C PF00147.18 PIK34025.1 - 8.3e-50 169.6 7.3 1.1e-49 169.3 7.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK34026.1 - 1e-22 81.0 0.7 1.4e-22 80.6 0.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RNA_pol_Rpb2_6 PF00562.28 PIK34028.1 - 9.3e-100 334.4 0.0 1.2e-99 334.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 PIK34028.1 - 1e-34 118.7 0.9 2e-34 117.9 0.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RVT_1 PF00078.27 PIK34030.1 - 2.6e-06 27.1 0.0 4.6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C4_ClpX PF06689.13 PIK34030.1 - 0.011 15.6 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 0 ClpX C4-type zinc finger RNA_pol_Rpb2_2 PF04561.14 PIK34031.1 - 2.9e-17 62.9 0.1 6.9e-17 61.7 0.1 1.5 1 1 1 2 2 2 2 RNA polymerase Rpb2, domain 2 RVT_1 PF00078.27 PIK34032.1 - 8.5e-16 58.1 0.0 1.6e-15 57.2 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK34032.1 - 0.00015 21.7 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HlyE PF06109.13 PIK34032.1 - 0.19 11.0 0.0 0.3 10.3 0.0 1.4 1 1 0 1 1 1 0 Haemolysin E (HlyE) RIBIOP_C PF04950.12 PIK34033.1 - 3.5e-116 387.7 0.0 6.6e-116 386.8 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 PIK34033.1 - 3e-11 43.2 0.0 7.6e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain p450 PF00067.22 PIK34034.1 - 3.9e-47 161.1 0.2 6.6e-47 160.3 0.2 1.3 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK34035.1 - 7.3e-09 34.9 0.0 8.2e-09 34.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FLYWCH_N PF15423.6 PIK34035.1 - 0.17 12.0 0.0 3.9 7.6 0.0 2.1 2 0 0 2 2 2 0 FLYWCH-type zinc finger-containing protein Filamin PF00630.19 PIK34036.1 - 9.6e-118 386.1 3.1 1.1e-17 64.7 0.0 10.2 9 1 1 10 10 10 9 Filamin/ABP280 repeat Y_Y_Y PF07495.13 PIK34036.1 - 2.6e-11 43.3 2.6 0.029 14.3 0.0 5.8 6 0 0 6 6 6 3 Y_Y_Y domain Big_3_5 PF16640.5 PIK34036.1 - 6e-09 36.0 3.3 1.7 8.9 0.0 7.1 7 0 0 7 7 7 2 Bacterial Ig-like domain (group 3) He_PIG PF05345.12 PIK34036.1 - 1e-07 32.0 3.4 0.14 12.4 0.0 5.6 5 0 0 5 5 5 1 Putative Ig domain DUF5060 PF16586.5 PIK34036.1 - 4.9e-07 30.0 0.0 8.4 6.9 0.0 6.5 6 0 0 6 6 6 1 Domain of unknown function (DUF5060) Invasin_D3 PF09134.10 PIK34036.1 - 2e-05 24.8 6.2 3.4 8.0 0.0 6.9 7 1 1 8 8 7 1 Invasin, domain 3 YtkA PF13115.6 PIK34036.1 - 2.5e-05 24.8 1.6 31 5.2 0.0 7.0 8 1 1 9 9 9 0 YtkA-like PKD PF00801.20 PIK34036.1 - 0.00022 21.0 1.0 1.6 8.6 0.1 6.1 6 0 0 6 6 6 1 PKD domain PapC_N PF13954.6 PIK34036.1 - 0.0074 16.3 0.0 3.2 7.8 0.0 4.2 5 0 0 5 5 5 1 PapC N-terminal domain Big_1 PF02369.16 PIK34036.1 - 0.013 15.4 0.1 4.6 7.3 0.0 4.2 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 1) DAP_epimerase PF01678.19 PIK34036.1 - 0.05 13.8 0.0 0.27 11.4 0.0 2.3 1 0 0 1 1 1 0 Diaminopimelate epimerase DUF2141 PF09912.9 PIK34036.1 - 0.052 13.5 0.0 14 5.6 0.0 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2141) DUF4364 PF14277.6 PIK34036.1 - 0.26 11.0 0.1 58 3.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4364) Big_3 PF07523.12 PIK34036.1 - 4.9 7.5 8.4 7.9 6.9 0.1 5.4 7 1 0 7 7 6 0 Bacterial Ig-like domain (group 3) DUF1619 PF07773.11 PIK34037.1 - 5.1e-13 49.6 10.4 8.8e-13 48.9 10.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1619) NACHT PF05729.12 PIK34039.1 - 1.3e-12 48.0 0.0 3.9e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK34039.1 - 0.0026 17.4 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK34039.1 - 0.033 13.4 0.0 0.062 12.5 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 PIK34039.1 - 0.081 12.1 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA PF00004.29 PIK34039.1 - 0.097 13.1 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) LRR_8 PF13855.6 PIK34041.1 - 4.1e-09 36.1 6.2 0.0009 19.0 0.3 3.6 2 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK34041.1 - 6.2e-07 29.6 9.7 0.2 12.1 0.3 4.1 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK34041.1 - 0.00043 20.1 0.8 2.9 8.2 0.1 4.4 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.33 PIK34041.1 - 0.99 10.2 2.7 23 6.1 0.1 3.7 2 1 0 2 2 2 0 Leucine Rich Repeat Lin-8 PF03353.15 PIK34042.1 - 0.54 9.8 9.1 0.57 9.7 9.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 PIK34042.1 - 2.1 7.0 3.3 2.2 6.9 3.3 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 PIK34042.1 - 4.4 7.2 25.6 6.1 6.7 25.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V-set PF07686.17 PIK34043.1 - 5.1e-09 36.3 3.8 0.0012 19.0 0.7 2.8 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK34043.1 - 0.00017 22.1 3.4 0.37 11.4 0.2 3.6 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK34043.1 - 0.00055 20.1 0.5 0.044 14.0 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK34043.1 - 0.04 14.3 0.8 0.28 11.6 0.8 2.3 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain SUI1 PF01253.22 PIK34044.1 - 0.076 13.5 1.2 0.29 11.7 0.0 2.5 3 0 0 3 3 3 0 Translation initiation factor SUI1 GARP PF16731.5 PIK34044.1 - 0.086 12.5 0.1 3.5 7.3 0.0 2.2 1 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma SET PF00856.28 PIK34045.1 - 8.8e-14 52.2 0.0 1.2e-12 48.5 0.0 2.3 2 1 0 2 2 2 1 SET domain MFS_1 PF07690.16 PIK34046.1 - 3.8e-06 26.1 1.3 3.9e-06 26.0 1.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily WD40 PF00400.32 PIK34047.1 - 0.012 16.4 0.0 27 5.8 0.0 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat HELP PF03451.14 PIK34047.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 HELP motif DUF1943 PF09172.11 PIK34048.1 - 1.4e-14 54.1 20.3 0.009 15.3 0.0 6.4 1 1 3 5 5 5 4 Domain of unknown function (DUF1943) DUF237 PF03072.14 PIK34048.1 - 1.9e-10 40.9 10.2 0.54 10.3 0.1 7.8 1 1 8 9 9 9 8 Domain of unknown function (DUF237) PorP_SprF PF11751.8 PIK34048.1 - 1.6e-09 37.7 29.3 0.0021 17.6 3.4 5.6 1 1 2 3 3 3 2 Type IX secretion system membrane protein PorP/SprF MspA PF09203.11 PIK34048.1 - 5.9e-07 29.5 9.2 3.6 7.4 9.2 5.9 1 1 0 1 1 1 1 MspA DUF481 PF04338.12 PIK34048.1 - 9e-07 29.1 11.0 0.12 12.4 0.2 4.5 1 1 2 3 3 3 3 Protein of unknown function, DUF481 OMP_b-brl_2 PF13568.6 PIK34048.1 - 0.00014 22.0 14.0 4.6 7.2 7.2 5.5 1 1 2 3 3 3 2 Outer membrane protein beta-barrel domain Porin_3 PF01459.22 PIK34048.1 - 0.0037 16.8 0.8 2.9 7.3 1.7 4.0 1 1 0 2 2 2 1 Eukaryotic porin DUF2490 PF10677.9 PIK34048.1 - 0.017 15.1 7.3 24 4.8 1.4 5.5 1 1 1 3 3 3 0 Protein of unknown function (DUF2490) DUF2715 PF10895.8 PIK34048.1 - 0.21 11.2 35.1 46 3.6 0.3 5.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2715) T2SSS_2 PF16549.5 PIK34048.1 - 0.41 10.7 50.3 1.1 9.3 0.5 11.0 1 1 11 12 12 12 0 Type II secretion system (T2SS) pilotin, S protein HA2 PF04408.23 PIK34049.1 - 1.2e-21 77.0 0.3 5.5e-21 74.9 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK34049.1 - 1e-16 61.0 0.0 3.3e-16 59.4 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK34049.1 - 3.5e-13 49.9 0.0 8.4e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK34049.1 - 0.018 14.8 0.2 0.032 14.0 0.2 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Exo_endo_phos PF03372.23 PIK34050.1 - 5.2e-09 36.0 0.0 9.3e-09 35.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK34050.1 - 1.4e-08 34.6 0.0 2.6e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase UPF0697 PF15117.6 PIK34050.1 - 0.078 13.1 0.5 0.39 10.8 0.0 2.1 2 1 0 2 2 2 0 Uncharacterised protein family UPF0697 LBP_BPI_CETP PF01273.25 PIK34051.1 - 0.0085 15.7 0.0 0.017 14.7 0.0 1.5 1 1 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain RseA_C PF03873.13 PIK34051.1 - 0.016 15.4 0.1 27 5.1 0.1 3.3 3 0 0 3 3 3 0 Anti sigma-E protein RseA, C-terminal domain LRR_4 PF12799.7 PIK34052.1 - 4.9e-12 45.8 18.5 3.6e-05 24.0 6.9 4.0 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK34052.1 - 5.8e-11 42.0 20.7 4.5e-06 26.3 7.9 3.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 PIK34052.1 - 2.1e-07 30.6 4.9 5.6e-05 22.7 0.5 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK34052.1 - 0.013 15.5 15.7 12 6.2 0.7 5.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 PIK34052.1 - 0.18 12.5 12.9 45 5.2 0.8 5.7 4 1 0 4 4 4 0 Leucine Rich Repeat Exo_endo_phos PF03372.23 PIK34053.1 - 0.0041 16.7 0.0 3.7 7.0 0.0 2.8 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family C6_DPF PF10170.9 PIK34054.1 - 1.2e-31 108.9 10.4 1.3e-31 108.8 10.4 1.0 1 0 0 1 1 1 1 Cysteine-rich domain FAM86 PF14904.6 PIK34054.1 - 0.083 13.0 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function ADH_zinc_N PF00107.26 PIK34055.1 - 1e-22 80.5 0.1 1.5e-22 79.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK34055.1 - 1.7e-15 58.2 0.0 2.4e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase RmlD_sub_bind PF04321.17 PIK34055.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain zf-CCHC PF00098.23 PIK34056.1 - 1.7e-05 24.7 1.1 3e-05 23.9 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle ABC_tran_Xtn PF12848.7 PIK34056.1 - 0.013 15.5 0.1 0.029 14.4 0.1 1.5 1 0 0 1 1 1 0 ABC transporter RT_RNaseH_2 PF17919.1 PIK34057.1 - 3.4e-27 94.4 0.0 8.1e-27 93.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34057.1 - 1.7e-24 86.1 0.0 3.3e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34057.1 - 2.8e-23 82.6 0.0 4.7e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_2b PF00587.25 PIK34058.1 - 1.1e-05 25.6 0.1 2.3e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 PIK34058.1 - 0.00029 21.0 6.2 0.00051 20.2 6.2 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 PIK34058.1 - 0.064 13.7 5.4 0.18 12.3 5.4 1.7 1 0 0 1 1 1 0 Cell division protein ZapB UPF0242 PF06785.11 PIK34058.1 - 3.2 7.8 7.7 18 5.3 7.6 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mod_r PF07200.13 PIK34058.1 - 9.8 6.3 10.7 1.1 9.3 4.1 2.5 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Phospholip_A2_1 PF00068.19 PIK34059.1 - 1.4e-23 83.5 9.5 1.7e-23 83.2 9.5 1.1 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 PIK34059.1 - 0.053 13.7 0.0 0.081 13.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP1 Phospholip_A2_2 PF05826.12 PIK34059.1 - 4.1 7.7 10.0 1.6 9.0 4.3 2.5 1 1 1 2 2 2 0 Phospholipase A2 RRP14 PF15459.6 PIK34060.1 - 0.013 16.1 0.4 0.021 15.4 0.4 1.3 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 SURF6 PF04935.12 PIK34061.1 - 1.5e-27 96.7 64.9 1.5e-27 96.7 64.9 3.2 1 1 1 2 2 2 1 Surfeit locus protein 6 Metallophos PF00149.28 PIK34062.1 - 1.2e-36 127.2 0.0 1.5e-36 126.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK34062.1 - 0.044 14.0 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain DUF5641 PF18701.1 PIK34063.1 - 3.6e-28 97.6 1.1 5.5e-28 97.0 1.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK34063.1 - 1.9e-11 44.2 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK34063.1 - 0.0022 17.7 0.0 0.0085 15.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DUF3110 PF11360.8 PIK34063.1 - 0.095 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) Cobalamin_bind PF01122.19 PIK34064.1 - 2.9e-09 36.3 0.0 3.5e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein SDA1 PF05285.12 PIK34064.1 - 1.6 8.1 23.4 1.9 7.9 23.4 1.1 1 0 0 1 1 1 0 SDA1 Cobalamin_bind PF01122.19 PIK34065.1 - 6.7e-23 81.1 0.0 1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.6 PIK34065.1 - 0.0049 17.4 0.0 0.0092 16.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) APH PF01636.23 PIK34067.1 - 7.6e-11 42.4 0.0 9.8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK34067.1 - 0.012 15.2 0.2 0.02 14.5 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TFIIE-A_C PF11521.8 PIK34068.1 - 0.012 15.8 1.1 0.021 15.1 1.1 1.3 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha CagX PF03524.15 PIK34068.1 - 0.55 9.9 2.6 0.84 9.3 2.6 1.5 1 1 0 1 1 1 0 Conjugal transfer protein C8 PF08742.11 PIK34069.1 - 8.5e-17 61.3 2.3 8.5e-17 61.3 2.3 3.1 2 1 1 3 3 3 1 C8 domain TIL PF01826.17 PIK34069.1 - 2.8e-09 37.1 17.5 2.8e-09 37.1 17.5 4.1 3 1 1 4 4 4 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK34069.1 - 1.4e-07 31.3 11.9 1.4e-07 31.3 11.9 3.9 2 1 2 4 4 4 1 TILa domain VWD PF00094.25 PIK34069.1 - 7.1e-07 29.6 2.8 7.1e-07 29.6 2.8 1.9 2 0 0 2 2 2 1 von Willebrand factor type D domain VWD PF00094.25 PIK34070.1 - 3.1e-148 489.0 17.5 1.4e-32 113.2 0.2 5.5 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.11 PIK34070.1 - 7.3e-57 189.7 79.6 4.3e-17 62.3 1.7 8.8 8 1 0 8 8 8 5 C8 domain TIL PF01826.17 PIK34070.1 - 3.2e-34 117.0 112.5 1.7e-09 37.8 16.5 15.4 12 4 2 14 14 14 5 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK34070.1 - 6.2e-21 74.1 40.0 2.3e-10 40.3 10.3 10.6 5 4 4 9 9 9 4 TILa domain EGF_3 PF12947.7 PIK34070.1 - 2.7e-13 49.9 50.7 2.2e-06 27.7 5.0 14.4 13 3 2 16 16 16 4 EGF domain S4 PF01479.25 PIK34070.1 - 2.1e-05 24.1 1.5 0.95 9.2 0.0 4.7 6 0 0 6 6 6 2 S4 domain FAP206 PF12018.8 PIK34070.1 - 0.18 11.3 1.5 1.1 8.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function VWD PF00094.25 PIK34071.1 - 7.4e-75 250.5 6.5 5.2e-33 114.5 0.6 4.3 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.11 PIK34071.1 - 1e-47 160.4 11.5 3.9e-18 65.6 0.6 6.9 6 1 0 6 6 6 3 C8 domain TILa PF12714.7 PIK34071.1 - 1.1e-25 89.3 45.4 7.5e-11 41.8 11.5 7.1 6 1 1 7 7 7 3 TILa domain TIL PF01826.17 PIK34071.1 - 7.2e-15 55.0 38.4 4.3e-09 36.5 17.5 9.4 7 3 2 9 9 9 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK34071.1 - 0.0011 19.1 16.8 0.0011 19.1 16.8 8.3 7 2 1 8 8 8 2 EGF domain S4 PF01479.25 PIK34071.1 - 0.0021 17.7 0.0 1.5 8.6 0.0 3.2 3 0 0 3 3 3 1 S4 domain VWD PF00094.25 PIK34072.1 - 2.9e-144 476.1 28.2 5.6e-32 111.2 3.5 5.2 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.11 PIK34072.1 - 9.6e-65 215.0 85.5 2.1e-18 66.5 1.4 8.3 8 0 0 8 8 8 5 C8 domain TILa PF12714.7 PIK34072.1 - 3e-33 113.6 103.0 1e-09 38.2 9.7 9.5 6 3 2 8 8 8 5 TILa domain TIL PF01826.17 PIK34072.1 - 5.2e-14 52.2 53.3 1.7e-09 37.8 16.0 15.4 12 4 1 13 13 13 4 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK34072.1 - 0.00028 21.0 26.2 0.00041 20.5 6.5 12.3 9 3 1 10 10 10 4 EGF domain Luciferase_N PF05295.11 PIK34072.1 - 0.094 12.7 0.1 4.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain VWD PF00094.25 PIK34073.1 - 3.4e-68 228.9 5.1 2.8e-37 128.4 0.3 2.7 3 0 0 3 3 3 2 von Willebrand factor type D domain C8 PF08742.11 PIK34073.1 - 8.4e-19 67.8 0.6 8.4e-19 67.8 0.6 2.5 2 0 0 2 2 2 1 C8 domain TILa PF12714.7 PIK34073.1 - 5e-11 42.4 7.7 5e-11 42.4 7.7 3.1 2 1 1 3 3 3 1 TILa domain TIL PF01826.17 PIK34073.1 - 1.8e-10 40.9 14.3 1.8e-10 40.9 14.3 3.8 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain fn3 PF00041.21 PIK34073.1 - 7.7e-07 29.4 2.7 0.00019 21.7 0.3 2.4 2 0 0 2 2 2 2 Fibronectin type III domain EGF_3 PF12947.7 PIK34073.1 - 0.00073 19.7 5.2 0.00073 19.7 5.2 4.1 3 1 1 4 4 4 1 EGF domain EGF_MSP1_1 PF12946.7 PIK34073.1 - 1.4 9.0 13.6 0.31 11.1 6.8 3.1 2 0 0 2 2 2 0 MSP1 EGF domain 1 7tm_1 PF00001.21 PIK34074.1 - 2.8e-35 121.9 16.8 4e-35 121.4 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK34074.1 - 1.8e-12 47.4 18.2 1.8e-12 47.4 18.2 2.5 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK34074.1 - 5.7e-06 25.8 28.1 9.7e-05 21.8 28.1 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Exo84_C PF16528.5 PIK34074.1 - 0.029 14.2 0.2 0.05 13.4 0.2 1.3 1 0 0 1 1 1 0 Exocyst component 84 C-terminal PX PF00787.24 PIK34076.1 - 2.1e-13 50.2 1.2 4e-13 49.3 1.2 1.5 1 1 0 1 1 1 1 PX domain TPR_12 PF13424.6 PIK34076.1 - 0.0041 17.4 0.1 0.007 16.6 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat RVT_1 PF00078.27 PIK34078.1 - 8.7e-27 94.1 0.0 1.4e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TUDOR PF00567.24 PIK34079.1 - 1.5e-22 79.9 0.1 2.4e-22 79.3 0.1 1.3 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 PIK34079.1 - 0.056 13.9 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 Agenet domain CRT10 PF08728.10 PIK34080.1 - 0.43 8.7 2.4 0.54 8.4 2.4 1.1 1 0 0 1 1 1 0 CRT10 Y_phosphatase PF00102.27 PIK34081.1 - 2.7e-35 122.0 0.7 1.2e-23 83.9 0.0 2.5 2 1 1 3 3 3 2 Protein-tyrosine phosphatase fn3_2 PF16893.5 PIK34081.1 - 0.0054 16.8 0.1 0.013 15.7 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain DSPc PF00782.20 PIK34081.1 - 0.0083 15.9 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK34081.1 - 0.029 14.7 0.1 0.079 13.3 0.1 1.8 1 0 0 1 1 1 0 Fibronectin type III domain fn3 PF00041.21 PIK34082.1 - 1e-05 25.7 0.1 2.2e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.6 PIK34083.1 - 0.0018 18.5 0.2 0.0046 17.3 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK34083.1 - 0.004 17.2 0.0 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK34083.1 - 0.0052 17.2 0.1 0.044 14.2 0.0 2.3 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK34083.1 - 0.014 15.4 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK34083.1 - 0.018 15.6 0.2 0.17 12.5 0.1 2.3 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK34083.1 - 0.021 15.0 0.0 0.054 13.7 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK34083.1 - 0.03 14.6 0.2 0.15 12.4 0.0 2.1 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain DUF1619 PF07773.11 PIK34084.1 - 6.8e-19 68.9 22.3 8.6e-19 68.6 22.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1619) 7tm_1 PF00001.21 PIK34086.1 - 0.00011 21.6 0.0 0.00013 21.4 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) AA_permease_2 PF13520.6 PIK34087.1 - 3.4e-25 88.8 22.5 3.9e-25 88.6 22.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK34087.1 - 5.1e-13 48.4 19.7 6e-13 48.2 19.7 1.0 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.12 PIK34087.1 - 0.00053 20.1 2.5 0.00053 20.1 2.5 2.1 1 1 0 2 2 2 1 Invasion gene expression up-regulator, SirB P4Ha_N PF08336.11 PIK34088.1 - 7.6e-35 119.9 0.9 1.3e-34 119.1 0.9 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 PIK34088.1 - 5.3e-13 49.7 0.0 1.4e-12 48.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 PIK34088.1 - 2.7e-06 27.8 0.0 5.3e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 PIK34088.1 - 0.00018 21.4 0.1 0.0031 17.5 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK34088.1 - 0.00035 20.6 0.0 0.00092 19.2 0.0 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 PIK34088.1 - 0.004 16.9 1.3 0.032 14.0 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK34088.1 - 0.022 15.0 0.0 0.97 9.7 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK34088.1 - 0.029 14.5 0.0 0.16 12.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK34088.1 - 0.068 14.0 1.7 3.3 8.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK34088.1 - 0.097 13.2 1.0 0.58 10.7 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4639 PF15479.6 PIK34089.1 - 1e-24 87.5 0.1 1.3e-24 87.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4639) DUF4639 PF15479.6 PIK34090.1 - 0.013 14.4 0.3 0.019 14.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) HMG_box PF00505.19 PIK34092.1 - 3e-21 75.6 0.2 3.9e-21 75.2 0.2 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK34092.1 - 1.5e-07 31.9 0.3 2.4e-07 31.2 0.3 1.3 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 PIK34092.1 - 0.009 15.3 0.2 0.01 15.2 0.2 1.1 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box HA2 PF04408.23 PIK34094.1 - 3.5e-16 59.4 0.1 1.3e-15 57.6 0.1 2.2 1 1 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK34094.1 - 2.4e-14 53.4 0.0 9.6e-14 51.5 0.0 2.1 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK34094.1 - 1.9e-12 47.5 0.0 4.3e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C2H2_4 PF13894.6 PIK34094.1 - 0.0089 16.8 2.9 0.2 12.6 1.1 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 PIK34094.1 - 0.016 15.5 2.3 0.7 10.2 0.6 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-Sec23_Sec24 PF04810.15 PIK34094.1 - 0.052 13.6 1.2 0.39 10.8 0.2 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-MIZ PF02891.20 PIK34094.1 - 0.15 11.9 1.5 1.8 8.4 0.2 2.6 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Rubredoxin PF00301.20 PIK34094.1 - 0.16 12.0 0.8 14 5.8 0.1 2.7 2 0 0 2 2 2 0 Rubredoxin zf_UBZ PF18439.1 PIK34094.1 - 0.18 11.5 3.7 0.76 9.4 0.5 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 PIK34094.1 - 1.4 9.5 3.6 7.7 7.2 1.6 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 PIK34094.1 - 2.3 8.8 8.8 0.35 11.4 0.3 2.9 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Dynactin_p62 PF05502.13 PIK34094.1 - 9.2 4.9 11.4 1.3 7.7 0.1 2.9 2 1 1 3 3 3 0 Dynactin p62 family DEAD PF00270.29 PIK34095.1 - 8.5e-05 22.4 0.4 0.0027 17.5 0.4 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 PIK34095.1 - 0.00073 18.7 0.0 0.0013 17.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_18 PF13238.6 PIK34095.1 - 0.0091 16.5 0.9 7.2 7.2 0.2 3.3 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 PIK34095.1 - 0.013 15.0 0.0 0.031 13.8 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 PIK34095.1 - 0.016 15.5 0.2 0.074 13.3 0.2 2.0 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 PIK34095.1 - 0.017 14.5 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 PIK34095.1 - 0.02 15.2 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 PIK34095.1 - 0.026 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 PIK34095.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 PIK34095.1 - 0.085 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK34095.1 - 0.092 13.3 0.0 0.35 11.4 0.0 1.9 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 PIK34095.1 - 0.1 11.9 0.8 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.6 PIK34095.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.4 1 1 1 2 2 1 0 AAA domain CoA_binding PF02629.19 PIK34096.1 - 1.8e-31 108.7 2.6 1.8e-31 108.7 2.6 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 PIK34096.1 - 2.6e-18 66.3 0.2 5.9e-18 65.1 0.2 1.6 1 1 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 PIK34096.1 - 7e-08 32.4 1.0 3.9e-07 30.0 0.3 2.4 2 1 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 PIK34096.1 - 3.3e-05 24.4 0.1 8.9e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain RNA_pol_Rpb2_6 PF00562.28 PIK34097.1 - 1e-123 413.3 0.4 1.4e-123 412.8 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 PIK34097.1 - 4.1e-58 196.3 0.0 7.2e-58 195.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 PIK34097.1 - 2.6e-48 164.2 0.0 6.1e-48 163.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 PIK34097.1 - 7.9e-34 115.9 0.5 1.7e-33 114.8 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 PIK34097.1 - 9.3e-25 86.7 0.3 2.7e-24 85.2 0.3 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 PIK34097.1 - 2.1e-24 85.4 0.0 4.8e-24 84.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 PIK34097.1 - 0.0035 17.9 0.2 0.0098 16.4 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Daxx PF03344.15 PIK34099.1 - 0.088 12.9 0.0 8.3 6.6 0.0 2.8 2 0 0 2 2 2 0 Daxx N-terminal Rassf1C-interacting domain Exo_endo_phos PF03372.23 PIK34101.1 - 0.0013 18.3 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ten_N PF06484.12 PIK34101.1 - 0.062 13.2 0.0 0.067 13.1 0.0 1.1 1 0 0 1 1 1 0 Teneurin Intracellular Region RT_RNaseH_2 PF17919.1 PIK34102.1 - 1.7e-22 79.3 0.3 4.5e-22 78.0 0.3 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK34102.1 - 1e-12 48.0 4.0 1.2e-12 47.7 1.0 2.3 1 1 1 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK34102.1 - 7.1e-09 35.9 0.0 1.5e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_pol3_tau_5 PF12170.8 PIK34103.1 - 0.044 13.8 2.1 1.5 8.8 0.3 2.3 2 0 0 2 2 2 0 DNA polymerase III tau subunit V interacting with alpha DUF4537 PF15057.6 PIK34103.1 - 0.087 12.9 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) zf-CCHC PF00098.23 PIK34104.1 - 1.9e-08 34.0 15.1 0.00028 20.8 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK34104.1 - 0.00072 19.3 10.6 0.23 11.3 6.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK34104.1 - 0.0027 17.6 16.0 0.079 12.9 1.0 3.8 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK34104.1 - 0.0032 17.2 11.1 2.1 8.1 0.3 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34104.1 - 0.0095 15.7 0.2 0.0095 15.7 0.2 3.3 3 0 0 3 3 3 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK34104.1 - 0.0096 15.6 0.8 0.0096 15.6 0.8 2.8 1 1 1 2 2 2 1 C2H2 zinc-finger RVT_1 PF00078.27 PIK34105.1 - 2.8e-15 56.5 0.1 1.2e-14 54.3 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK34107.1 - 7e-24 84.6 0.0 9.7e-24 84.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1759 PF03564.15 PIK34108.1 - 0.15 12.0 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) RVT_1 PF00078.27 PIK34110.1 - 4.2e-25 88.6 0.0 6.1e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK34111.1 - 2.3e-34 117.8 0.1 3.3e-34 117.3 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK34111.1 - 1.1e-32 112.0 0.1 1.8e-32 111.3 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 PIK34111.1 - 0.055 13.5 0.0 0.084 12.9 0.0 1.2 1 0 0 1 1 1 0 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK34112.1 - 3.3e-23 82.4 0.0 3.9e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF787 PF05619.11 PIK34113.1 - 0.0027 16.9 0.3 0.004 16.4 0.3 1.2 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF787) EST1_DNA_bind PF10373.9 PIK34114.1 - 1e-23 84.3 0.0 1.3e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 PIK34114.1 - 1.7e-14 54.6 0.0 2.7e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Telomerase activating protein Est1 TPR_1 PF00515.28 PIK34114.1 - 0.13 12.2 5.5 0.48 10.3 0.4 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK34114.1 - 0.61 10.3 11.6 0.8 10.0 0.2 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Ribosomal_S17e PF00833.18 PIK34115.1 - 4.1e-45 152.6 2.1 4.6e-23 81.4 0.1 2.1 2 0 0 2 2 2 2 Ribosomal S17 Diphthami_syn_2 PF01902.17 PIK34116.1 - 6.9e-29 100.9 0.0 1.7e-28 99.7 0.0 1.5 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 PIK34116.1 - 9.1e-13 48.3 0.0 4e-08 33.3 0.0 2.4 1 1 1 2 2 2 2 Endoribonuclease L-PSP DUF2025 PF09634.10 PIK34116.1 - 0.13 12.3 0.1 0.89 9.6 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2025) G-patch PF01585.23 PIK34117.1 - 1.1e-16 60.4 2.6 2.2e-16 59.5 2.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK34117.1 - 1.3e-08 34.8 1.2 2.9e-08 33.7 1.2 1.6 1 0 0 1 1 1 1 G-patch domain Dehydrin PF00257.19 PIK34117.1 - 0.1 13.1 6.5 0.054 14.1 4.1 1.8 2 0 0 2 2 2 0 Dehydrin baeRF_family12 PF18856.1 PIK34117.1 - 0.18 12.4 0.1 0.18 12.4 0.1 2.0 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 12 DUF4216 PF13952.6 PIK34118.1 - 1.2e-11 44.8 0.0 2.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4216) PDZ PF00595.24 PIK34119.1 - 1.3e-08 35.1 0.3 3.3e-08 33.8 0.2 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK34119.1 - 2.1e-06 27.4 0.3 5.4e-06 26.2 0.3 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK34119.1 - 0.004 17.5 0.2 0.017 15.4 0.0 2.2 2 1 1 3 3 3 1 PDZ domain YL1 PF05764.13 PIK34119.1 - 0.045 13.9 2.0 0.054 13.6 2.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CN_hydrolase PF00795.22 PIK34122.1 - 1.4e-26 93.4 0.0 1.6e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Kelch_6 PF13964.6 PIK34122.1 - 0.077 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Kelch motif p450 PF00067.22 PIK34123.1 - 1.2e-22 80.4 0.0 1.4e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK34124.1 - 1.5e-06 27.3 0.1 1.8e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 RVT_1 PF00078.27 PIK34125.1 - 1e-33 116.7 0.0 1.4e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK34126.1 - 1.1e-05 25.2 15.2 0.002 18.1 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK34126.1 - 2.8e-05 23.8 14.1 0.17 11.6 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34126.1 - 0.0018 18.0 0.2 0.0018 18.0 0.2 3.1 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK34126.1 - 1 9.6 12.4 0.42 10.9 6.7 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain CPT_N PF16484.5 PIK34128.1 - 0.19 11.8 0.1 0.35 10.9 0.1 1.4 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus RhoGAP PF00620.27 PIK34130.1 - 2.5e-39 134.5 0.9 1.2e-38 132.3 0.0 2.6 3 1 0 3 3 3 1 RhoGAP domain FCH PF00611.23 PIK34131.1 - 1.6e-15 57.1 1.3 2.7e-15 56.4 0.9 1.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF3037 PF11236.8 PIK34131.1 - 0.034 14.6 0.1 0.17 12.3 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) HA2 PF04408.23 PIK34132.1 - 5.8e-23 81.2 0.0 5.8e-23 81.2 0.0 3.4 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK34132.1 - 1.2e-22 80.1 0.0 3.3e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK34132.1 - 6.4e-08 32.9 0.1 9.6e-07 29.1 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK34132.1 - 7.9e-07 29.0 0.2 1.8e-06 27.8 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 PIK34132.1 - 0.00013 22.3 0.1 0.0003 21.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK34132.1 - 0.00016 21.5 0.0 0.00036 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK34132.1 - 0.0012 18.2 0.7 0.0037 16.6 0.0 2.1 2 0 0 2 2 2 1 KaiC AAA_22 PF13401.6 PIK34132.1 - 0.0013 19.0 0.0 0.0051 17.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK34132.1 - 0.0023 17.0 0.0 0.0046 16.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 PIK34132.1 - 0.041 13.3 0.0 0.15 11.5 0.0 1.9 1 0 0 1 1 1 0 PhoH-like protein tRNA-Thr_ED PF08915.11 PIK34132.1 - 0.21 11.6 1.3 1.4 9.0 1.5 2.3 2 0 0 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase SNF2_N PF00176.23 PIK34133.1 - 1.1e-68 231.6 4.0 2.1e-68 230.6 4.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.13 PIK34133.1 - 6.7e-21 74.4 7.1 6.7e-21 74.4 7.1 4.0 2 1 1 3 3 3 2 HSA Helicase_C PF00271.31 PIK34133.1 - 1.6e-18 67.1 0.0 7e-18 65.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK34133.1 - 9.7e-08 32.0 0.1 7.4e-05 22.6 0.0 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 PIK34133.1 - 5.7e-07 29.7 0.1 5.7e-07 29.7 0.1 3.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CRAL_TRIO_2 PF13716.6 PIK34134.1 - 1.4e-28 99.8 1.8 2.4e-28 99.0 1.8 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 PIK34134.1 - 6.8e-05 22.6 0.4 0.00015 21.5 0.4 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain DHHA2 PF02833.14 PIK34135.1 - 6e-15 55.7 0.1 6e-09 36.2 0.1 2.5 1 1 1 2 2 2 2 DHHA2 domain DHH PF01368.20 PIK34135.1 - 2.2e-07 31.0 0.0 5.5e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 DHH family AKAP7_RIRII_bdg PF10470.9 PIK34135.1 - 0.053 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein DUF5320 PF17253.2 PIK34136.1 - 0.01 16.9 0.8 0.01 16.9 0.8 2.5 1 1 0 2 2 2 1 Family of unknown function (DUF5320) Rotamase PF00639.21 PIK34136.1 - 0.38 11.7 6.7 0.64 11.0 6.1 1.7 1 1 1 2 2 2 0 PPIC-type PPIASE domain FAM76 PF16046.5 PIK34136.1 - 2.1 7.6 13.4 2.7 7.3 13.4 1.2 1 0 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 PIK34136.1 - 7.3 6.1 12.6 8 5.9 12.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RCC1 PF00415.18 PIK34137.1 - 4.6e-37 126.4 10.7 8.4e-15 55.1 0.1 4.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK34137.1 - 1.4e-17 62.9 16.5 2.7e-07 30.2 1.5 3.2 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Methyltranf_PUA PF13636.6 PIK34137.1 - 0.0076 16.2 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 2 RNA-binding PUA-like domain of methyltransferase RsmF Gal-3-0_sulfotr PF06990.11 PIK34138.1 - 6.1e-43 147.2 0.1 7.7e-43 146.9 0.1 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase VWA PF00092.28 PIK34139.1 - 1.4e-23 84.0 0.1 5.2e-16 59.4 0.3 2.2 1 1 1 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 PIK34139.1 - 2.3e-06 28.2 0.0 4.3e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF2717 PF10911.8 PIK34141.1 - 0.0039 16.9 15.3 56 3.5 0.2 10.6 3 3 3 6 6 6 4 Protein of unknown function (DUF2717) Scramblase PF03803.15 PIK34142.1 - 4.2e-62 209.3 0.0 5.2e-62 209.0 0.0 1.1 1 0 0 1 1 1 1 Scramblase Exo_endo_phos PF03372.23 PIK34143.1 - 1.2e-10 41.3 0.0 1.8e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK34143.1 - 2.5e-10 40.2 0.0 4.4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ERM PF00769.19 PIK34145.1 - 8.2e-06 25.8 26.8 9e-06 25.7 26.8 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Tfb5 PF06331.12 PIK34145.1 - 0.042 13.8 0.3 0.068 13.2 0.3 1.4 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 FERM_C PF09380.10 PIK34146.1 - 2.8e-27 95.0 0.0 7.6e-27 93.6 0.0 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK34146.1 - 1.1e-26 93.5 0.3 1.1e-26 93.5 0.3 2.0 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 PIK34146.1 - 5.8e-14 51.8 0.5 1.7e-13 50.3 0.1 2.0 3 0 0 3 3 3 1 FERM N-terminal domain ACBP PF00887.19 PIK34146.1 - 0.0061 16.7 0.0 0.0061 16.7 0.0 2.9 3 1 0 3 3 3 1 Acyl CoA binding protein AAA_23 PF13476.6 PIK34146.1 - 0.14 12.6 7.9 0.24 11.9 7.9 1.5 1 0 0 1 1 1 0 AAA domain DUF4337 PF14235.6 PIK34146.1 - 3.1 7.9 15.8 6.5 6.8 15.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Fer2 PF00111.27 PIK34147.1 - 2.1e-06 27.6 0.3 3e-06 27.1 0.3 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain adh_short PF00106.25 PIK34148.1 - 5.3e-16 58.7 0.0 6.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK34148.1 - 8.8e-09 35.3 0.0 1.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase zf-C3HC4 PF00097.25 PIK34149.1 - 1.7e-10 40.6 7.1 1.7e-10 40.6 7.1 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK34149.1 - 9.8e-10 38.3 4.1 9.8e-10 38.3 4.1 2.6 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK34149.1 - 5.3e-08 32.6 8.3 5.3e-08 32.6 8.3 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK34149.1 - 1.1e-07 32.1 7.2 1.1e-07 32.1 7.2 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK34149.1 - 1.1e-07 31.9 9.8 1.1e-07 31.9 9.8 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK34149.1 - 2.2e-07 30.6 9.3 2.2e-07 30.6 9.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK34149.1 - 1.4e-05 24.9 6.4 1.4e-05 24.9 6.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 PIK34149.1 - 0.0046 16.7 6.7 0.027 14.2 3.0 3.1 1 1 1 2 2 2 1 RING-like zinc finger CHAT PF12770.7 PIK34149.1 - 0.013 14.9 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 CHAT domain Prok-RING_4 PF14447.6 PIK34149.1 - 0.026 14.4 9.3 0.026 14.4 9.3 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.6 PIK34149.1 - 0.88 10.1 0.1 0.88 10.1 0.1 3.6 3 1 0 3 3 3 0 Zinc-finger double domain CarboxypepD_reg PF13620.6 PIK34153.1 - 0.0027 17.9 0.1 0.024 14.9 0.1 2.6 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain fn3_3 PF14686.6 PIK34153.1 - 0.019 14.7 0.1 16 5.3 0.0 3.2 3 0 0 3 3 3 0 Polysaccharide lyase family 4, domain II DUF2012 PF09430.10 PIK34153.1 - 0.025 14.7 0.0 8.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 PIK34154.1 - 1.8e-09 37.7 0.4 4.1e-07 30.2 0.1 3.7 3 1 0 3 3 3 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 PIK34154.1 - 7.3e-07 29.4 0.0 0.0078 16.4 0.0 3.3 3 1 0 3 3 3 2 SdrD B-like domain CarbopepD_reg_2 PF13715.6 PIK34154.1 - 2e-05 24.5 0.7 0.0021 18.0 0.1 3.0 2 1 1 3 3 3 1 CarboxypepD_reg-like domain SpaA PF17802.1 PIK34154.1 - 0.0017 18.7 0.0 1.7 9.0 0.1 2.5 2 0 0 2 2 2 2 Prealbumin-like fold domain DUF1416 PF07210.12 PIK34154.1 - 0.058 13.3 0.1 4.3 7.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1416) Mer2 PF09074.10 PIK34155.1 - 0.00085 19.2 1.8 0.0011 18.8 1.8 1.1 1 0 0 1 1 1 1 Mer2 Lipoprotein_2 PF00921.17 PIK34155.1 - 0.0029 17.2 2.6 0.0036 16.9 2.6 1.0 1 0 0 1 1 1 1 Borrelia lipoprotein APG17 PF04108.12 PIK34155.1 - 0.0037 16.5 0.7 0.004 16.3 0.7 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 HEPN_AbiU2 PF18734.1 PIK34155.1 - 0.0097 15.4 3.5 1 8.8 0.4 2.3 2 0 0 2 2 2 2 AbiU2 CK2S PF15011.6 PIK34155.1 - 0.022 14.7 0.3 0.035 14.0 0.3 1.4 1 1 0 1 1 1 0 Casein Kinase 2 substrate Syntaxin_2 PF14523.6 PIK34155.1 - 0.022 15.1 5.3 1.2 9.5 1.6 2.2 1 1 1 2 2 2 0 Syntaxin-like protein Latarcin PF10279.9 PIK34155.1 - 0.033 14.6 3.8 0.16 12.4 0.4 2.3 2 0 0 2 2 2 0 Latarcin precursor DUF1451 PF07295.11 PIK34155.1 - 0.042 13.9 2.8 0.12 12.4 0.7 2.0 1 1 1 2 2 2 0 Zinc-ribbon containing domain Med9 PF07544.13 PIK34155.1 - 0.056 13.5 5.4 0.13 12.4 0.8 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PNPase PF03726.14 PIK34155.1 - 0.057 13.9 2.8 1.8 9.1 0.2 2.2 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain TcdB_N PF12918.7 PIK34155.1 - 0.062 13.6 1.1 0.22 11.9 0.8 2.2 1 1 1 2 2 2 0 TcdB toxin N-terminal helical domain AAA PF00004.29 PIK34155.1 - 0.064 13.7 0.3 0.07 13.6 0.3 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) JHD PF17811.1 PIK34155.1 - 0.067 13.7 2.6 0.1 13.2 2.6 1.2 1 0 0 1 1 1 0 Jumonji helical domain SASA PF03629.18 PIK34155.1 - 0.072 12.7 0.3 0.12 12.0 0.3 1.3 1 0 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase ATPase PF06745.13 PIK34155.1 - 0.087 12.2 0.3 0.12 11.7 0.3 1.2 1 0 0 1 1 1 0 KaiC zf-C2H2_3 PF13878.6 PIK34155.1 - 0.098 12.5 0.3 0.21 11.4 0.3 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Allexi_40kDa PF05549.11 PIK34155.1 - 0.12 11.9 0.7 0.13 11.7 0.7 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF1640 PF07798.11 PIK34155.1 - 0.14 12.2 3.9 0.19 11.7 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF883 PF05957.13 PIK34155.1 - 0.18 12.4 1.5 0.65 10.6 0.6 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ParD PF09386.10 PIK34155.1 - 0.34 11.3 2.2 1.6 9.1 0.2 2.1 1 1 0 2 2 2 0 Antitoxin ParD Elongin_A PF06881.11 PIK34155.1 - 0.36 11.4 4.6 0.78 10.3 4.6 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A MSC PF09402.10 PIK34155.1 - 0.63 9.4 5.0 6.4 6.1 4.9 2.1 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain Pex14_N PF04695.13 PIK34155.1 - 3.3 8.4 5.4 8.4 7.0 5.4 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3740 PF12548.8 PIK34155.1 - 7.7 6.9 10.1 9.7 6.6 0.5 2.5 1 1 2 3 3 3 0 Sulfatase protein Ig_3 PF13927.6 PIK34156.1 - 5.4e-07 30.1 1.1 0.00095 19.7 0.0 3.1 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK34156.1 - 8e-06 26.0 0.4 0.0075 16.4 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK34156.1 - 0.00021 21.3 0.2 0.038 14.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK34156.1 - 0.00032 20.8 0.9 0.13 12.5 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK34156.1 - 0.052 14.0 0.2 0.38 11.2 0.1 2.5 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain NACHT PF05729.12 PIK34157.1 - 1.4e-12 47.9 0.0 2.5e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK34157.1 - 3.8e-06 27.4 4.5 0.0069 17.0 0.2 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK34157.1 - 1.6e-05 24.9 0.3 1.6e-05 24.9 0.3 3.3 3 1 1 4 4 4 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK34157.1 - 2e-05 24.6 0.3 0.28 11.3 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin I-set domain NB-ARC PF00931.22 PIK34157.1 - 0.0001 21.6 0.0 0.00026 20.2 0.0 1.7 1 0 0 1 1 1 1 NB-ARC domain V-set PF07686.17 PIK34157.1 - 0.00016 21.8 3.0 0.0056 16.8 0.7 3.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK34157.1 - 0.0011 19.3 4.9 0.0018 18.6 1.1 3.0 3 0 0 3 3 2 1 Immunoglobulin C1-set domain Pilin_N PF07790.11 PIK34157.1 - 0.022 15.6 0.2 7 7.6 0.0 3.3 3 0 0 3 3 3 0 Archaeal Type IV pilin, N-terminal ResIII PF04851.15 PIK34157.1 - 0.045 13.7 0.2 0.16 12.0 0.1 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DnaB_C PF03796.15 PIK34157.1 - 0.048 13.0 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 PIK34157.1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 PIK34157.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) N6_N4_Mtase PF01555.18 PIK34159.1 - 1.8e-08 34.4 0.0 2.3e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_25 PF13649.6 PIK34159.1 - 0.00034 21.3 0.1 0.00073 20.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34159.1 - 0.015 15.9 0.0 0.03 15.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NACHT PF05729.12 PIK34160.1 - 9.2e-08 32.2 0.0 1.5e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.6 PIK34160.1 - 0.0003 20.8 0.1 0.0011 19.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 PIK34160.1 - 0.0029 17.7 0.3 0.046 13.8 0.1 2.5 1 1 1 2 2 2 1 Sigma-54 interaction domain UPF0154 PF03672.13 PIK34160.1 - 0.0042 17.1 2.0 0.48 10.5 0.1 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) ATPase PF06745.13 PIK34160.1 - 0.0053 16.1 0.9 0.021 14.2 0.2 2.2 2 1 0 2 2 2 1 KaiC DAP3 PF10236.9 PIK34160.1 - 0.022 13.9 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Hexokinase_2 PF03727.16 PIK34162.1 - 2.9e-75 252.8 0.1 5.4e-72 242.1 0.1 2.2 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 PIK34162.1 - 1.9e-67 227.0 0.0 2.9e-67 226.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase HSP70 PF00012.20 PIK34162.1 - 0.083 11.1 0.0 0.12 10.5 0.0 1.2 1 0 0 1 1 1 0 Hsp70 protein zf-C2H2_jaz PF12171.8 PIK34163.1 - 9e-05 22.6 2.9 9e-05 22.6 2.9 1.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK34163.1 - 0.002 18.5 3.5 0.0037 17.6 3.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type ZapB PF06005.12 PIK34163.1 - 0.044 14.2 0.4 14 6.2 0.1 2.3 2 0 0 2 2 2 0 Cell division protein ZapB zf-C2H2_2 PF12756.7 PIK34163.1 - 0.06 13.7 0.7 0.06 13.7 0.7 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 PIK34163.1 - 0.076 13.1 1.5 0.099 12.8 0.6 1.7 2 0 0 2 2 2 0 DBF zinc finger zf-U1 PF06220.12 PIK34163.1 - 0.16 11.7 4.2 0.39 10.5 3.4 1.9 2 0 0 2 2 2 0 U1 zinc finger Tetraspanin PF00335.20 PIK34164.1 - 7.6e-39 133.8 2.3 9e-39 133.5 2.3 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2206 PF09971.9 PIK34164.1 - 0.00089 18.1 6.9 0.0011 17.8 6.9 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2206) STE3 PF02076.15 PIK34164.1 - 0.023 13.9 0.8 0.023 13.9 0.8 1.6 2 0 0 2 2 2 0 Pheromone A receptor TadE PF07811.12 PIK34164.1 - 0.024 14.9 0.3 0.024 14.9 0.3 2.8 3 0 0 3 3 3 0 TadE-like protein MARVEL PF01284.23 PIK34164.1 - 0.26 11.3 14.0 0.7 9.9 0.8 2.8 1 1 1 2 2 2 0 Membrane-associating domain ASFV_J13L PF05568.11 PIK34164.1 - 0.54 10.0 2.4 0.59 9.9 1.8 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein Phage_holin_3_6 PF07332.11 PIK34164.1 - 0.54 10.3 7.7 0.078 13.0 1.3 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III 7tm_2 PF00002.24 PIK34165.1 - 1.4e-12 47.4 30.0 2.8e-12 46.5 30.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK34165.1 - 8.2e-08 32.7 2.5 2.7e-07 31.0 2.5 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Calx-beta PF03160.14 PIK34165.1 - 0.049 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Calx-beta domain DUF4083 PF13314.6 PIK34165.1 - 0.1 12.6 0.0 0.41 10.6 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) RVT_1 PF00078.27 PIK34166.1 - 5.9e-05 22.7 0.0 0.00022 20.8 0.0 1.9 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Calx-beta PF03160.14 PIK34167.1 - 8e-19 67.7 3.8 5e-09 36.3 0.3 3.8 4 1 0 4 4 4 2 Calx-beta domain DUF4843 PF16132.5 PIK34167.1 - 0.016 14.8 0.0 0.7 9.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) Calx-beta PF03160.14 PIK34168.1 - 3.4e-56 187.6 20.9 6.8e-17 61.5 1.4 8.7 9 0 0 9 9 9 8 Calx-beta domain Calx-beta PF03160.14 PIK34169.1 - 5.9e-56 186.8 17.7 1.4e-11 44.4 1.1 7.4 7 0 0 7 7 7 6 Calx-beta domain EPTP PF03736.17 PIK34169.1 - 1.3e-19 69.9 19.9 1.7e-06 27.9 0.2 6.7 7 1 0 7 7 7 4 EPTP domain Na_Pi_cotrans PF02690.15 PIK34169.1 - 0.13 12.4 0.4 5.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Na+/Pi-cotransporter PAN_2 PF08276.11 PIK34169.1 - 0.17 12.0 0.2 0.4 10.8 0.2 1.5 1 0 0 1 1 1 0 PAN-like domain Calx-beta PF03160.14 PIK34170.1 - 6.6e-17 61.5 0.4 9.8e-16 57.8 0.1 2.0 2 0 0 2 2 2 1 Calx-beta domain Pkinase PF00069.25 PIK34171.1 - 1.2e-29 103.5 0.2 1.4e-29 103.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34171.1 - 5.3e-26 91.5 0.0 6.3e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK34171.1 - 3.7e-05 22.7 0.1 7.9e-05 21.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase PUF PF00806.19 PIK34172.1 - 1.8e-14 52.5 8.6 0.28 11.0 0.0 9.5 10 0 0 10 10 10 5 Pumilio-family RNA binding repeat Amj PF10997.8 PIK34172.1 - 0.027 13.8 0.1 0.057 12.7 0.1 1.5 1 0 0 1 1 1 0 Alternate to MurJ RSV_NS2 PF03113.14 PIK34172.1 - 0.079 13.0 0.3 0.46 10.5 0.0 2.2 2 0 0 2 2 2 0 Respiratory synctial virus non-structural protein NS2 DNA_pol_E_B PF04042.16 PIK34172.1 - 0.1 11.9 0.5 39 3.5 0.0 3.1 3 0 0 3 3 3 0 DNA polymerase alpha/epsilon subunit B UPF0489 PF12640.7 PIK34173.1 - 2.7e-35 122.2 1.0 5.1e-35 121.3 1.0 1.5 1 0 0 1 1 1 1 UPF0489 domain DUF3039 PF11238.8 PIK34174.1 - 0.093 12.5 0.8 0.093 12.5 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3039) Ribosomal_S27e PF01667.17 PIK34174.1 - 3.6 7.4 9.6 4.1 7.2 0.8 2.5 2 1 0 2 2 2 0 Ribosomal protein S27 Fer4_7 PF12838.7 PIK34174.1 - 4.2 8.0 9.6 0.16 12.6 1.1 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain rve PF00665.26 PIK34176.1 - 6.6e-26 90.8 0.1 1.1e-25 90.1 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK34176.1 - 1.3e-19 70.0 1.4 2.8e-19 69.0 1.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK34176.1 - 4.1e-05 23.3 0.3 0.0001 22.0 0.1 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK34176.1 - 8.4e-05 22.7 0.7 0.00023 21.3 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Gifsy-2 PF13856.6 PIK34176.1 - 0.085 13.2 0.0 0.24 11.8 0.0 1.7 1 1 0 1 1 1 0 ATP-binding sugar transporter from pro-phage RVT_1 PF00078.27 PIK34177.1 - 2.7e-30 105.6 0.1 5.8e-30 104.5 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK34177.1 - 3.7e-29 100.7 0.0 9.3e-29 99.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34177.1 - 1.5e-24 86.3 0.0 8.8e-24 83.8 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK34177.1 - 9.4e-08 32.5 0.0 3.4e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK34177.1 - 2.7e-06 27.9 0.0 2.5e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease SlyX PF04102.12 PIK34177.1 - 0.15 12.7 0.2 0.46 11.1 0.2 1.8 1 0 0 1 1 1 0 SlyX V-set PF07686.17 PIK34178.1 - 8.4e-06 25.9 2.8 1.9e-05 24.7 0.3 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain DUF2207 PF09972.9 PIK34178.1 - 0.004 16.0 1.7 0.024 13.4 1.7 1.9 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 PIK34178.1 - 0.0053 16.7 1.0 0.011 15.6 1.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family TRP PF06011.12 PIK34178.1 - 0.0074 15.1 0.3 0.009 14.8 0.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel ECSCR PF15820.5 PIK34178.1 - 0.011 15.6 0.1 0.011 15.6 0.1 2.2 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator Baculo_11_kDa PF06143.11 PIK34178.1 - 0.017 14.7 0.7 0.051 13.1 0.7 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family Stevor PF17410.2 PIK34178.1 - 0.025 14.1 4.6 0.052 13.1 4.6 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame MRAP PF15183.6 PIK34178.1 - 0.045 13.7 0.1 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family ASFV_J13L PF05568.11 PIK34178.1 - 0.097 12.4 0.1 0.097 12.4 0.1 1.9 2 0 0 2 2 2 0 African swine fever virus J13L protein Claudin_3 PF06653.11 PIK34178.1 - 0.12 12.3 3.1 0.28 11.1 3.0 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Ig_3 PF13927.6 PIK34178.1 - 0.18 12.4 0.1 0.18 12.4 0.1 2.8 3 0 0 3 3 3 0 Immunoglobulin domain DUF4834 PF16118.5 PIK34178.1 - 0.19 12.7 1.7 0.42 11.6 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) HemY_N PF07219.13 PIK34178.1 - 0.21 11.8 0.5 0.35 11.1 0.5 1.3 1 0 0 1 1 1 0 HemY protein N-terminus DUF4713 PF15831.5 PIK34178.1 - 1.3 9.6 8.2 3.1 8.3 8.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Pkinase PF00069.25 PIK34179.1 - 3.7e-56 190.4 0.1 5.9e-54 183.2 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34179.1 - 1.9e-25 89.6 0.0 5.5e-20 71.7 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase cNMP_binding PF00027.29 PIK34179.1 - 1.5e-16 60.3 0.1 1.2e-15 57.4 0.0 2.2 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Kinase-like PF14531.6 PIK34179.1 - 0.00073 18.9 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK34179.1 - 0.0017 17.2 0.0 0.0031 16.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 PIK34179.1 - 0.011 15.4 0.1 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 PIK34179.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LZ_Tnp_IS481 PF13011.6 PIK34179.1 - 0.14 12.7 0.0 0.34 11.5 0.0 1.6 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 UNC-93 PF05978.16 PIK34180.1 - 2.3e-11 43.6 7.6 2.3e-11 43.6 7.6 3.1 2 2 0 2 2 2 2 Ion channel regulatory protein UNC-93 DUF3827 PF12877.7 PIK34181.1 - 3.2e-15 55.6 0.1 1e-14 53.9 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3827) DUF2362 PF10154.9 PIK34182.1 - 1.1e-133 446.8 17.4 1.5e-102 344.1 13.2 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2362) CRM1_C PF08767.11 PIK34182.1 - 0.00049 19.4 2.3 0.00075 18.8 2.3 1.2 1 0 0 1 1 1 1 CRM1 C terminal DUF4887 PF16228.5 PIK34182.1 - 0.053 13.7 0.8 0.053 13.7 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) ATG13 PF10033.9 PIK34183.1 - 3.1e-15 56.5 1.2 1.4e-07 31.5 0.1 3.3 1 1 1 2 2 2 2 Autophagy-related protein 13 DUF3869 PF12985.7 PIK34183.1 - 0.053 13.9 0.1 0.12 12.7 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3869) S10_plectin PF03501.15 PIK34184.1 - 8e-48 160.5 0.3 1e-47 160.2 0.3 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Replic_Relax PF13814.6 PIK34184.1 - 0.02 15.0 0.1 0.027 14.5 0.1 1.1 1 0 0 1 1 1 0 Replication-relaxation Gag_p30 PF02093.16 PIK34184.1 - 0.047 13.2 0.2 0.18 11.3 0.1 1.8 1 1 1 2 2 2 0 Gag P30 core shell protein TrmB PF01978.19 PIK34184.1 - 0.056 13.3 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 PIK34184.1 - 0.17 11.7 0.2 0.27 11.1 0.2 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit RVT_1 PF00078.27 PIK34185.1 - 4.4e-26 91.8 0.0 6e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4378 PF14309.6 PIK34186.1 - 0.024 15.0 5.7 0.31 11.4 1.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4378) RHH_6 PF16762.5 PIK34186.1 - 4.1 8.1 5.8 6.5 7.4 0.0 3.7 4 1 1 5 5 5 0 Ribbon-helix-helix domain EI24 PF07264.11 PIK34187.1 - 4.2e-20 72.7 11.6 5.5e-20 72.4 11.6 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Methyltransf_25 PF13649.6 PIK34188.1 - 1.4e-06 28.9 0.1 2.8e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 PIK34188.1 - 0.00012 21.6 0.0 0.00016 21.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 PIK34188.1 - 0.00024 21.0 0.0 0.00028 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK34188.1 - 0.003 16.9 0.1 0.0035 16.7 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK34188.1 - 0.0092 16.7 0.1 0.017 15.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34188.1 - 0.0095 16.6 0.1 0.024 15.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34188.1 - 0.012 15.4 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 PIK34188.1 - 0.025 13.7 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase PrmA PF06325.13 PIK34188.1 - 0.044 13.2 0.1 0.056 12.8 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 PIK34188.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase RVT_1 PF00078.27 PIK34189.1 - 7.9e-28 97.5 0.0 1.1e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NodZ PF05830.11 PIK34189.1 - 0.14 11.0 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) rve PF00665.26 PIK34190.1 - 3.5e-17 62.7 0.0 6.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK34190.1 - 0.0013 18.8 1.7 0.0033 17.5 1.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK34190.1 - 0.0019 17.9 0.1 0.017 14.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK34190.1 - 0.058 13.5 0.2 0.1 12.7 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 SCAN PF02023.17 PIK34191.1 - 2.6e-13 49.6 0.0 6.6e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK34191.1 - 2.1e-06 27.5 2.0 4e-06 26.6 2.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34191.1 - 0.0042 16.9 1.4 0.0077 16.0 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle PRP3 PF08572.10 PIK34192.1 - 1.7e-44 152.2 14.6 1.7e-44 152.2 14.6 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 PIK34192.1 - 3.5e-25 88.8 0.7 3.5e-25 88.8 0.7 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1115) PRP3 PF08572.10 PIK34193.1 - 2.8e-13 50.1 0.4 2.8e-13 50.1 0.4 2.4 3 1 0 3 3 3 1 pre-mRNA processing factor 3 (PRP3) PWI PF01480.17 PIK34193.1 - 1e-07 32.2 0.0 2.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 PWI domain TMV_coat PF00721.21 PIK34193.1 - 0.17 11.7 2.3 0.17 11.7 0.6 2.0 2 0 0 2 2 2 0 Virus coat protein (TMV like) GcrA PF07750.11 PIK34193.1 - 3.2 8.1 5.3 1.2 9.5 1.8 2.0 2 0 0 2 2 2 0 GcrA cell cycle regulator Iso_dh PF00180.20 PIK34194.1 - 1.8e-37 129.3 0.0 2e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 PIK34195.1 - 1.8e-23 83.3 0.0 2.1e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AlaDh_PNT_C PF01262.21 PIK34196.1 - 3.9e-56 189.7 0.0 5.4e-56 189.3 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 PIK34196.1 - 6.4e-12 45.9 0.0 1.5e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 PIK34196.1 - 2.6e-10 40.6 0.1 2.6e-10 40.6 0.1 2.5 3 0 0 3 3 3 1 4TM region of pyridine nucleotide transhydrogenase, mitoch PNTB PF02233.16 PIK34196.1 - 0.00026 20.1 0.3 0.00046 19.2 0.3 1.3 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit 2-Hacid_dh_C PF02826.19 PIK34196.1 - 0.0011 18.4 0.7 0.56 9.5 0.2 2.5 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RBR PF17208.3 PIK34196.1 - 0.072 13.8 1.1 0.15 12.8 1.1 1.5 1 0 0 1 1 1 0 RNA binding Region Pyr_redox_2 PF07992.14 PIK34196.1 - 0.091 12.0 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PNTB PF02233.16 PIK34197.1 - 3.7e-66 223.9 1.6 2.1e-33 116.0 0.3 2.0 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit RXLR_WY PF18634.1 PIK34200.1 - 0.017 15.1 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 RXLR phytopathogen effector protein WY-domain STT3 PF02516.14 PIK34201.1 - 2.9e-131 438.8 23.0 2.7e-128 429.0 18.0 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit EMC3_TMCO1 PF01956.16 PIK34201.1 - 0.014 15.2 0.2 0.065 13.0 0.0 2.2 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Patched PF02460.18 PIK34202.1 - 3.3e-162 541.5 13.5 3.8e-162 541.3 13.5 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK34202.1 - 8.8e-41 139.3 6.4 8.8e-41 139.3 6.4 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 PIK34202.1 - 0.0014 16.4 14.0 0.0022 15.8 14.0 1.2 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF3007 PF11460.8 PIK34202.1 - 0.18 12.1 0.2 0.18 12.1 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3007) AAA_11 PF13086.6 PIK34204.1 - 2.9e-11 43.6 0.0 4.4e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK34204.1 - 2.5e-08 34.4 0.0 4.9e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK34204.1 - 9.1e-06 25.1 0.0 1.6e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 PIK34204.1 - 3.8e-05 23.8 0.0 4.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 PIK34204.1 - 0.00013 21.8 0.0 0.00018 21.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 PIK34204.1 - 0.0014 18.1 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein UvrD-helicase PF00580.21 PIK34204.1 - 0.0022 17.6 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 PIK34204.1 - 0.0027 17.5 0.0 0.0051 16.6 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK34204.1 - 0.0028 18.0 0.0 0.0059 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK34204.1 - 0.0069 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK34204.1 - 0.013 15.9 0.3 0.053 13.9 0.3 1.8 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK34204.1 - 0.019 15.0 0.0 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK34204.1 - 0.023 15.1 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 PIK34204.1 - 0.028 14.1 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 PIK34204.1 - 0.068 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 PIK34204.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 PIK34204.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_12 PF13087.6 PIK34205.1 - 1.4e-38 132.5 0.0 3.8e-38 131.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK34205.1 - 1.8e-10 41.0 0.2 1.8e-10 41.0 0.2 2.8 2 1 0 2 2 2 1 AAA domain DHC_N1 PF08385.12 PIK34206.1 - 0.013 14.1 4.0 0.02 13.5 4.0 1.2 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 DED PF01335.21 PIK34206.1 - 0.015 15.5 0.0 0.051 13.9 0.0 1.9 1 0 0 1 1 1 0 Death effector domain Prominin PF05478.11 PIK34206.1 - 0.03 12.3 7.1 0.042 11.8 7.1 1.1 1 0 0 1 1 1 0 Prominin SOAR PF16533.5 PIK34206.1 - 0.099 12.6 5.8 0.21 11.6 5.8 1.6 1 0 0 1 1 1 0 STIM1 Orai1-activating region Acyl-CoA_dh_N PF02771.16 PIK34206.1 - 0.11 13.1 0.2 0.24 12.1 0.2 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Ku_PK_bind PF08785.11 PIK34206.1 - 0.12 12.5 3.1 0.29 11.3 3.1 1.6 1 0 0 1 1 1 0 Ku C terminal domain like zf-B_box PF00643.24 PIK34206.1 - 0.13 12.4 8.6 0.29 11.3 8.6 1.6 1 0 0 1 1 1 0 B-box zinc finger REF PF05755.12 PIK34206.1 - 0.17 11.7 0.4 0.76 9.6 0.2 2.0 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) NBD94 PF16830.5 PIK34206.1 - 0.3 11.5 13.1 4.8 7.7 2.0 2.5 1 1 1 2 2 2 0 Nucleotide-Binding Domain 94 of RH DASH_Dam1 PF08653.10 PIK34206.1 - 0.31 10.9 1.3 15 5.5 0.3 3.2 2 1 0 2 2 2 0 DASH complex subunit Dam1 Latarcin PF10279.9 PIK34206.1 - 0.31 11.5 5.4 0.36 11.3 0.8 2.5 2 0 0 2 2 2 0 Latarcin precursor Cgr1 PF03879.14 PIK34206.1 - 5.3 7.5 9.4 0.44 11.0 1.5 2.2 1 1 1 2 2 2 0 Cgr1 family Mab-21 PF03281.14 PIK34207.1 - 1.1e-100 336.7 0.0 1.3e-100 336.5 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Fibrinogen_C PF00147.18 PIK34208.1 - 2.7e-46 158.1 5.7 3.6e-46 157.7 5.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF3060 PF11259.8 PIK34209.1 - 0.31 10.8 2.2 0.76 9.5 2.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3060) HECT PF00632.25 PIK34211.1 - 1.7e-09 37.6 0.0 2.2e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) rve PF00665.26 PIK34212.1 - 7.5e-07 29.4 0.0 1.8e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_Crp_2 PF13545.6 PIK34212.1 - 0.0093 15.9 0.4 0.39 10.7 0.0 2.5 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain RWP-RK PF02042.15 PIK34212.1 - 0.016 15.2 0.4 0.052 13.5 0.0 2.0 2 0 0 2 2 2 0 RWP-RK domain HTH_17 PF12728.7 PIK34212.1 - 0.027 14.7 0.0 0.66 10.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_3 PF01381.22 PIK34212.1 - 0.09 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_ECF PF07638.11 PIK34212.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 ECF sigma factor Ig_3 PF13927.6 PIK34213.1 - 4.1e-07 30.5 4.8 0.016 15.8 0.1 4.4 3 1 1 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK34213.1 - 4.6e-05 23.7 1.5 0.057 13.7 0.0 4.1 3 1 1 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK34213.1 - 0.00031 20.7 0.5 0.12 12.5 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK34213.1 - 0.0013 18.9 0.8 0.24 11.6 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain DAG1 PF05454.11 PIK34213.1 - 0.0033 16.9 0.3 0.0057 16.1 0.3 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) I-set PF07679.16 PIK34213.1 - 0.0075 16.3 0.1 1.7 8.7 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 PIK34213.1 - 0.012 15.7 0.1 0.072 13.3 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin V-set domain ECSCR PF15820.5 PIK34213.1 - 0.017 14.9 0.3 0.017 14.9 0.3 1.9 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.6 PIK34213.1 - 0.056 13.4 0.6 0.11 12.3 0.6 1.5 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 PIK34213.1 - 0.058 14.3 0.8 0.2 12.5 0.3 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 PIK34213.1 - 0.32 10.8 2.7 0.16 11.8 0.6 1.6 2 0 0 2 2 2 0 Rifin NTP_transferase PF00483.23 PIK34214.1 - 2.7e-16 59.9 0.0 3e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 PIK34214.1 - 1.3e-10 41.9 0.0 1.4e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 PIK34214.1 - 0.00021 21.1 0.0 0.00025 20.8 0.0 1.1 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 PIK34214.1 - 0.0029 17.6 0.0 0.0041 17.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase TGF_beta PF00019.20 PIK34215.1 - 1.5e-19 70.9 2.4 3.6e-19 69.7 2.4 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain NAD_binding_1 PF00175.21 PIK34216.1 - 8.4e-17 61.8 0.0 1.1e-16 61.4 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 PIK34216.1 - 2.8e-06 27.5 0.1 5.5e-06 26.6 0.1 1.6 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 PIK34216.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Hamartin PF04388.12 PIK34218.1 - 2 7.0 13.0 2.6 6.6 13.0 1.1 1 0 0 1 1 1 0 Hamartin protein RVT_1 PF00078.27 PIK34220.1 - 7.5e-33 113.9 0.1 9e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_S8 PF00082.22 PIK34221.1 - 4.1e-30 105.1 7.2 4.8e-30 104.8 7.2 1.0 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK34221.1 - 0.0015 19.2 0.0 0.0031 18.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 RVT_1 PF00078.27 PIK34223.1 - 1.2e-42 145.9 0.0 2.3e-42 145.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Baculo_FP PF03258.14 PIK34223.1 - 0.085 13.0 0.9 0.16 12.1 0.9 1.4 1 0 0 1 1 1 0 Baculovirus FP protein CybS PF05328.12 PIK34224.1 - 1.1e-27 96.3 0.2 1.3e-27 96.1 0.2 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit MFS_2 PF13347.6 PIK34225.1 - 5.8e-12 44.9 4.0 7.5e-12 44.5 4.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 PIK34225.1 - 5.1e-10 38.8 9.6 6.4e-10 38.5 9.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PUCC PF03209.15 PIK34225.1 - 0.00037 19.6 0.9 0.00048 19.3 0.9 1.1 1 0 0 1 1 1 1 PUCC protein Sugar_tr PF00083.24 PIK34225.1 - 0.00085 18.3 6.8 0.00096 18.1 5.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter DUF5641 PF18701.1 PIK34226.1 - 8e-27 93.2 1.2 1.2e-26 92.6 1.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DDE_Tnp_1_7 PF13843.6 PIK34227.1 - 0.00024 20.5 0.0 0.00027 20.3 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 DPM3 PF08285.11 PIK34229.1 - 3.8e-25 87.9 0.7 4.7e-25 87.6 0.7 1.1 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF2013 PF09431.10 PIK34230.1 - 3.6e-29 101.7 1.1 1e-28 100.3 0.1 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2013) SH3_1 PF00018.28 PIK34230.1 - 2.4e-09 36.7 0.0 4.5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK34230.1 - 8.4e-09 35.0 0.0 1.9e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK34230.1 - 8.8e-09 35.1 0.1 1.5e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK34230.1 - 0.00055 20.2 0.1 0.0019 18.5 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 PIK34230.1 - 0.012 15.6 0.1 0.041 13.9 0.0 1.9 2 0 0 2 2 2 0 SH3 domain DUF4777 PF16007.5 PIK34230.1 - 0.13 12.6 0.0 0.35 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) RT_RNaseH_2 PF17919.1 PIK34232.1 - 6.3e-16 58.3 0.0 3e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34232.1 - 6.6e-07 29.6 0.0 1.5e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34232.1 - 5.9e-05 22.7 0.0 9.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK34232.1 - 0.04 14.0 1.4 0.085 13.0 1.4 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK34232.1 - 0.17 11.6 2.7 0.39 10.5 2.7 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Integrase_H2C2 PF17921.1 PIK34233.1 - 5.3e-17 61.7 0.1 1.1e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK34233.1 - 1.9e-05 24.8 0.1 9.3e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK34233.1 - 0.055 13.7 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 H2C2 zinc finger zf-H3C2 PF16721.5 PIK34233.1 - 0.074 13.4 0.0 0.91 9.9 0.0 2.5 2 1 1 3 3 3 0 Zinc-finger like, probable DNA-binding DHHC PF01529.20 PIK34234.1 - 9.2e-25 87.3 14.0 9.2e-25 87.3 14.0 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase IGFBP PF00219.18 PIK34234.1 - 6 7.6 12.2 0.53 11.0 6.7 1.9 2 1 0 2 2 2 0 Insulin-like growth factor binding protein 7tm_1 PF00001.21 PIK34235.1 - 2.1e-13 50.2 0.1 2.7e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GWT1 PF06423.12 PIK34235.1 - 0.67 10.1 3.1 3 8.0 3.0 1.9 1 1 0 1 1 1 0 GWT1 LMBR1 PF04791.16 PIK34235.1 - 0.79 8.6 5.4 0.53 9.1 4.2 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein Ketoacyl-synt_C PF02801.22 PIK34236.1 - 6.6e-40 135.8 0.3 9.2e-40 135.3 0.3 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 PIK34236.1 - 9e-13 48.7 0.0 1.9e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ketoacyl-synt PF00109.26 PIK34236.1 - 1.8e-10 40.8 0.1 6.6e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 PIK34237.1 - 5.6e-50 170.7 0.2 7.8e-40 137.3 0.1 2.0 2 0 0 2 2 2 2 Acyl transferase domain Abhydrolase_6 PF12697.7 PIK34237.1 - 0.16 12.6 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family KR PF08659.10 PIK34238.1 - 1.4e-46 158.6 0.0 3.2e-46 157.5 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 PIK34238.1 - 1.4e-17 63.9 0.0 2.2e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 PIK34238.1 - 1.9e-15 56.9 0.0 4e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK34238.1 - 2.8e-13 50.0 0.0 5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 PIK34238.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 PIK34238.1 - 0.19 11.6 0.2 1.3 8.9 0.0 2.4 3 0 0 3 3 3 0 YjeF-related protein N-terminus Methyltransf_11 PF08241.12 PIK34239.1 - 8.5e-28 96.8 0.0 2.7e-18 66.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 PIK34239.1 - 8e-26 90.6 0.0 5.6e-17 62.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34239.1 - 1.8e-19 70.0 0.0 1.5e-11 44.3 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK34239.1 - 5e-13 49.6 0.0 2.4e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK34239.1 - 1.2e-12 48.0 0.0 1.1e-09 38.4 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain NodS PF05401.11 PIK34239.1 - 1.5e-09 37.7 0.0 3.4e-09 36.6 0.0 1.5 2 0 0 2 2 2 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 PIK34239.1 - 5.7e-07 29.1 0.0 1.3e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 PIK34239.1 - 2.2e-06 27.4 0.0 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 PIK34239.1 - 2.2e-05 24.1 0.0 5.4e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain TehB PF03848.14 PIK34239.1 - 6.4e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.20 PIK34239.1 - 0.00015 20.9 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CheR PF01739.18 PIK34239.1 - 0.00021 20.9 1.0 0.0055 16.2 0.1 2.7 1 1 1 3 3 3 1 CheR methyltransferase, SAM binding domain PCMT PF01135.19 PIK34239.1 - 0.00039 20.2 0.0 0.003 17.3 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 PIK34239.1 - 0.0069 16.1 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 PIK34240.1 - 3.1e-19 69.5 0.1 7.9e-16 58.6 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK34240.1 - 1.1e-16 61.2 0.0 1.8e-08 34.4 0.0 3.2 2 1 1 3 3 3 3 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34240.1 - 1.5e-15 57.6 1.8 6e-14 52.5 0.0 3.1 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34240.1 - 1.1e-13 51.3 0.4 8.2e-11 41.9 0.0 3.0 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK34240.1 - 4e-10 40.3 1.8 2.5e-08 34.6 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain NodS PF05401.11 PIK34240.1 - 4.6e-10 39.4 0.0 9.3e-10 38.4 0.0 1.4 2 0 0 2 2 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 PIK34240.1 - 1.9e-09 37.2 0.3 6.6e-07 28.9 0.0 3.0 2 1 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 PIK34240.1 - 2e-09 37.3 0.6 9e-09 35.2 0.0 2.2 3 0 0 3 3 3 1 AdoMet dependent proline di-methyltransferase TehB PF03848.14 PIK34240.1 - 2.9e-09 36.6 0.0 2.5e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Tellurite resistance protein TehB PCMT PF01135.19 PIK34240.1 - 5.2e-08 32.9 0.0 0.0091 15.8 0.0 2.5 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 PIK34240.1 - 2.2e-06 27.3 0.2 0.027 14.0 0.0 2.7 2 1 1 3 3 3 2 Methyltransferase small domain CMAS PF02353.20 PIK34240.1 - 4.1e-06 26.3 0.4 0.0031 16.9 0.1 2.6 3 0 0 3 3 3 2 Mycolic acid cyclopropane synthetase CheR PF01739.18 PIK34240.1 - 9.5e-06 25.2 0.1 2.5e-05 23.8 0.1 1.7 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain RrnaAD PF00398.20 PIK34240.1 - 3.8e-05 22.9 0.4 0.0062 15.6 0.1 2.2 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 PIK34240.1 - 4e-05 23.0 0.0 0.018 14.3 0.0 3.1 2 1 0 3 3 3 1 O-methyltransferase domain PrmA PF06325.13 PIK34240.1 - 6.5e-05 22.5 0.0 0.13 11.6 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 PIK34240.1 - 6.9e-05 21.9 0.2 0.0037 16.2 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1698) Fibrillarin PF01269.17 PIK34240.1 - 0.012 14.7 0.0 0.057 12.5 0.0 2.1 2 0 0 2 2 2 0 Fibrillarin UPF0020 PF01170.18 PIK34240.1 - 0.062 13.0 0.1 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 GCD14 PF08704.10 PIK34240.1 - 0.067 12.9 0.0 8.5 6.0 0.0 2.3 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_24 PF13578.6 PIK34240.1 - 0.2 12.7 0.0 1.6 9.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain zf-C2H2 PF00096.26 PIK34241.1 - 4.3e-16 58.4 24.5 0.00019 21.7 1.3 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK34241.1 - 2e-13 49.9 24.2 0.0014 19.3 0.6 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK34241.1 - 1.3e-11 44.3 21.4 4.1e-09 36.4 0.0 5.5 6 0 0 6 6 5 2 Zinc-finger double domain zf-C2HE PF16278.5 PIK34241.1 - 3.5e-07 30.6 11.6 0.0008 19.8 0.4 4.3 3 1 1 4 4 4 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 PIK34241.1 - 2.1e-06 28.0 15.6 0.046 14.0 0.6 4.0 2 2 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK34241.1 - 0.00054 19.7 10.1 0.086 12.6 0.3 3.5 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-BED PF02892.15 PIK34241.1 - 0.00094 19.1 10.5 0.62 10.1 1.1 3.6 2 1 1 3 3 3 2 BED zinc finger zf-C2H2_8 PF15909.5 PIK34241.1 - 0.0048 17.2 6.2 0.0099 16.2 0.5 2.7 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-Di19 PF05605.12 PIK34241.1 - 0.044 14.1 1.3 0.044 14.1 1.3 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 PIK34241.1 - 0.055 14.2 6.5 0.33 11.7 0.7 2.6 2 0 0 2 2 2 0 zinc-ribbon family PyrI_C PF02748.15 PIK34241.1 - 0.062 13.2 9.7 0.09 12.7 0.1 3.3 4 0 0 4 4 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GIT_CC PF16559.5 PIK34241.1 - 0.16 11.9 4.8 0.39 10.6 4.8 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor T4_Gp59_N PF08993.10 PIK34241.1 - 0.19 12.2 0.9 0.41 11.1 0.9 1.5 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase zf-C2H2_3rep PF18868.1 PIK34241.1 - 0.2 12.3 9.5 9 7.0 0.1 3.7 2 2 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats PriA_CRR PF18319.1 PIK34241.1 - 0.53 10.3 6.6 0.45 10.5 0.2 2.9 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain zf-met PF12874.7 PIK34241.1 - 0.53 10.8 19.1 6.4 7.3 1.0 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type HNH_5 PF14279.6 PIK34241.1 - 0.61 10.0 3.8 54 3.8 0.1 3.5 3 0 0 3 3 3 0 HNH endonuclease Zn_ribbon_recom PF13408.6 PIK34241.1 - 0.89 10.1 8.2 0.094 13.2 2.3 2.5 3 1 0 3 3 2 0 Recombinase zinc beta ribbon domain zf-C2H2_jaz PF12171.8 PIK34241.1 - 1.1 9.7 25.6 1.8 9.0 2.1 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK34241.1 - 2.1 8.2 18.3 1.1 9.1 1.9 4.0 3 1 0 3 3 3 0 C2H2-type zinc-finger domain FYVE PF01363.21 PIK34241.1 - 2.8 8.2 9.8 1.8 8.7 1.7 2.6 2 0 0 2 2 2 0 FYVE zinc finger zf-AN1 PF01428.16 PIK34241.1 - 4.8 7.4 6.7 52 4.1 0.2 3.6 3 0 0 3 3 3 0 AN1-like Zinc finger Methyltransf_11 PF08241.12 PIK34242.1 - 0.069 13.8 0.2 0.41 11.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain zf-C2H2 PF00096.26 PIK34242.1 - 0.32 11.5 2.5 0.59 10.7 2.5 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK34243.1 - 2.3e-11 43.5 40.2 0.0018 19.0 3.1 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK34243.1 - 2.5e-09 37.1 42.9 0.0008 19.7 4.0 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK34243.1 - 1.7e-05 25.0 35.1 0.03 14.7 1.8 6.1 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_8 PF15909.5 PIK34243.1 - 0.017 15.4 5.3 0.36 11.1 2.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2HE PF16278.5 PIK34243.1 - 0.023 15.1 23.3 0.78 10.2 0.0 4.7 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 PIK34243.1 - 0.051 13.9 1.0 0.051 13.9 1.0 4.4 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding DNA_RNApol_7kD PF03604.13 PIK34243.1 - 0.073 12.8 2.6 3.9 7.2 0.2 3.4 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz PF12171.8 PIK34243.1 - 1.6 9.1 27.1 0.77 10.1 0.3 5.0 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 PIK34243.1 - 1.8 8.4 9.7 1.3 8.9 0.8 3.4 3 0 0 3 3 3 0 GAGA factor DUF629 PF04780.12 PIK34243.1 - 3.1 6.2 19.8 1.5 7.3 0.0 4.3 3 2 2 5 5 5 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 PIK34244.1 - 2e-16 59.5 30.0 2.6e-05 24.4 1.3 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK34244.1 - 5.5e-14 51.9 26.4 3.2e-07 30.5 0.8 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK34244.1 - 4.5e-13 48.8 27.5 0.0037 18.0 0.8 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK34244.1 - 3e-10 39.7 2.3 3e-10 39.7 2.3 4.3 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 PIK34244.1 - 5.8e-05 23.4 15.1 1.1 9.6 0.7 4.1 1 1 2 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK34244.1 - 0.00089 19.6 20.2 0.29 11.6 0.8 4.6 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK34244.1 - 0.0023 18.2 21.8 0.19 12.0 0.1 4.7 4 1 0 4 4 4 3 Zinc-finger double-stranded RNA-binding DUF4599 PF15371.6 PIK34244.1 - 0.0099 16.4 1.4 0.0099 16.4 1.4 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4599) zf-C2H2_3rep PF18868.1 PIK34244.1 - 0.031 14.9 10.0 0.24 12.1 0.6 3.3 1 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats DUF3716 PF12511.8 PIK34244.1 - 0.15 12.2 0.3 0.15 12.2 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3716) zf-C2H2_7 PF15269.6 PIK34244.1 - 0.21 11.7 0.1 0.21 11.7 0.1 3.3 1 1 2 3 3 3 0 Zinc-finger C1_2 PF03107.16 PIK34244.1 - 0.5 10.7 13.7 3.7 8.0 0.1 3.9 3 1 0 3 3 3 0 C1 domain Zn_ribbon_SprT PF17283.2 PIK34244.1 - 0.85 9.6 9.4 21 5.2 3.3 3.5 2 2 0 2 2 2 0 SprT-like zinc ribbon domain Rpr2 PF04032.16 PIK34244.1 - 1.1 9.6 10.7 5.7 7.3 3.9 2.7 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Actin_micro PF17003.5 PIK34244.1 - 2.3 7.3 11.8 0.48 9.5 3.5 2.8 1 1 1 2 2 2 0 Putative actin-like family CTU2 PF10288.9 PIK34244.1 - 5.3 7.3 7.8 2.3e+02 2.1 7.4 3.2 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2H2 PF00096.26 PIK34245.1 - 8.8e-18 63.7 13.1 4.4e-07 30.0 1.2 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK34245.1 - 1.6e-14 53.4 9.8 3.8e-05 24.2 0.3 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK34245.1 - 1.5e-13 50.6 1.5 0.00031 20.9 0.0 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK34245.1 - 4.7e-13 48.9 8.6 5e-08 33.0 0.0 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 PIK34245.1 - 5.2e-12 45.7 6.8 0.00032 21.0 0.1 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK34245.1 - 1.4e-07 31.1 7.5 0.00036 20.2 0.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_9 PF16293.5 PIK34245.1 - 1.7e-05 24.6 5.5 0.2 11.5 0.1 3.2 2 1 1 3 3 3 3 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 PIK34245.1 - 1.9e-05 24.3 12.0 0.007 16.1 2.8 2.8 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 PIK34245.1 - 0.00013 21.9 9.1 0.029 14.4 0.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK34245.1 - 0.00053 20.2 7.6 0.036 14.3 2.5 2.7 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-Sec23_Sec24 PF04810.15 PIK34245.1 - 0.003 17.6 3.8 5 7.3 0.1 3.2 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger zf-C2H2_2 PF12756.7 PIK34245.1 - 0.0048 17.2 9.8 17 5.8 10.8 3.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 PIK34245.1 - 0.0075 16.1 2.6 0.49 10.2 0.0 3.0 1 1 2 3 3 3 1 GAGA factor zf-C2H2_8 PF15909.5 PIK34245.1 - 0.017 15.4 2.0 0.05 13.9 2.0 1.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon CTU2 PF10288.9 PIK34245.1 - 0.042 14.1 8.1 0.3 11.3 2.1 2.8 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 FYDLN_acid PF09538.10 PIK34245.1 - 0.046 14.4 1.1 0.055 14.2 0.1 1.5 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) Elf1 PF05129.13 PIK34245.1 - 0.052 13.6 5.4 1.8 8.7 1.1 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.10 PIK34245.1 - 0.08 13.1 1.5 1.8 8.7 0.2 2.3 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 PIK34245.1 - 0.092 12.8 3.7 0.3 11.2 3.7 1.8 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 PIK34245.1 - 0.1 13.4 2.2 0.92 10.3 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 PIK34245.1 - 0.14 12.8 2.9 5.6 7.6 0.4 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats OrfB_Zn_ribbon PF07282.11 PIK34245.1 - 0.17 11.9 3.2 0.25 11.3 1.0 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain C1_2 PF03107.16 PIK34245.1 - 0.18 12.1 8.2 1.4 9.3 3.6 3.1 1 1 1 2 2 2 0 C1 domain zf_UBZ PF18439.1 PIK34245.1 - 0.24 11.0 3.9 12 5.6 0.2 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Actin_micro PF17003.5 PIK34245.1 - 0.48 9.5 5.8 1.9 7.5 0.2 2.6 1 1 2 3 3 3 0 Putative actin-like family Ima1_N PF09779.9 PIK34245.1 - 0.57 11.0 7.2 0.18 12.7 3.2 2.1 1 1 1 2 2 2 0 Ima1 N-terminal domain Zn-C2H2_12 PF18112.1 PIK34245.1 - 0.68 10.4 0.1 0.68 10.4 0.1 3.2 3 1 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_3 PF13878.6 PIK34245.1 - 2 8.3 9.5 8.2 6.3 0.1 3.3 1 1 2 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-RING_5 PF14634.6 PIK34245.1 - 3.9 7.5 8.0 13 5.8 0.2 2.9 2 1 1 3 3 3 0 zinc-RING finger domain UBZ_FAAP20 PF15750.5 PIK34245.1 - 5 7.1 8.2 13 5.8 0.6 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger LRR_8 PF13855.6 PIK34246.1 - 1.6e-16 59.8 16.7 4.4e-10 39.2 1.6 3.5 1 1 3 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK34246.1 - 2e-05 24.6 7.4 9.9e-05 22.3 4.8 2.1 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ephrin_rec_like PF07699.13 PIK34246.1 - 0.00016 21.3 5.8 0.00016 21.3 5.8 4.9 2 1 3 5 5 5 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK34246.1 - 0.0013 18.7 27.5 0.014 15.3 1.4 4.3 4 0 0 4 4 4 3 Nine Cysteines Domain of family 3 GPCR LRR_4 PF12799.7 PIK34246.1 - 0.0046 17.3 8.8 0.28 11.7 1.4 3.8 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK34246.1 - 0.017 14.6 0.6 0.032 13.7 0.6 1.4 1 0 0 1 1 1 0 Leucine-rich repeat Pept_S41_N PF18294.1 PIK34246.1 - 0.029 14.4 2.8 12 6.0 0.0 2.7 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain Beta_helix PF13229.6 PIK34246.1 - 0.041 13.7 6.6 0.079 12.8 6.6 1.4 1 0 0 1 1 1 0 Right handed beta helix region LRR_6 PF13516.6 PIK34246.1 - 0.11 12.6 0.3 8 6.8 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich repeat TRP PF06011.12 PIK34246.1 - 0.38 9.4 12.7 0.14 10.8 8.7 2.2 2 1 0 2 2 2 0 Transient receptor potential (TRP) ion channel YtpI PF14007.6 PIK34246.1 - 8.8 6.5 11.1 1.6 8.9 0.0 3.8 4 0 0 4 4 4 0 YtpI-like protein LRR_8 PF13855.6 PIK34247.1 - 3.7e-20 71.5 5.8 1.4e-13 50.4 0.8 3.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 PIK34247.1 - 4.6e-15 55.7 1.1 5.5e-15 55.5 1.1 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK34247.1 - 1.6e-10 41.1 8.0 6.6e-05 23.2 0.0 3.3 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK34247.1 - 1.6e-05 24.8 3.8 0.64 10.8 0.0 4.7 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK34247.1 - 0.00015 21.6 12.3 1 9.6 0.0 5.0 5 0 0 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.6 PIK34247.1 - 0.0092 15.5 0.6 0.12 11.9 0.1 1.8 1 1 1 2 2 2 1 Leucine-rich repeat zf-CCHC PF00098.23 PIK34248.1 - 6.9e-10 38.5 14.4 0.00017 21.5 0.9 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34248.1 - 0.0067 16.2 2.4 0.0067 16.2 2.4 3.2 3 1 1 4 4 4 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK34248.1 - 0.04 13.9 14.1 0.51 10.3 2.3 3.7 1 1 2 3 3 3 0 Zinc knuckle Ribosomal_L40e PF01020.17 PIK34248.1 - 2.3 8.2 11.7 0.79 9.7 7.1 2.3 1 1 1 2 2 2 0 Ribosomal L40e family zf-CCHC_4 PF14392.6 PIK34248.1 - 7.9 6.3 12.6 3 7.7 0.6 3.3 1 1 2 3 3 3 0 Zinc knuckle zf-C3HC4_2 PF13923.6 PIK34249.1 - 1e-10 41.2 9.1 1e-10 41.2 9.1 2.5 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK34249.1 - 7.5e-09 35.5 6.9 7.5e-09 35.5 6.9 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK34249.1 - 4.8e-08 33.2 8.5 4.8e-08 33.2 8.5 3.2 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 PIK34249.1 - 7.3e-08 32.2 8.1 7.3e-08 32.2 8.1 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK34249.1 - 9.5e-07 28.6 5.0 9.5e-07 28.6 5.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK34249.1 - 1.7e-06 28.1 8.0 1.7e-06 28.1 8.0 2.5 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK34249.1 - 6.1e-06 26.0 8.0 2e-05 24.4 8.0 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK34249.1 - 2.2e-05 24.3 6.2 2.2e-05 24.3 6.2 2.7 3 1 0 3 3 2 1 zinc-RING finger domain zf-TRAF PF02176.18 PIK34249.1 - 0.0017 19.0 5.3 0.0017 19.0 5.3 3.0 1 1 1 2 2 2 1 TRAF-type zinc finger Sina PF03145.16 PIK34249.1 - 0.0049 16.8 2.8 0.0049 16.8 2.8 2.3 1 1 1 2 2 2 1 Seven in absentia protein family zf-RING_6 PF14835.6 PIK34249.1 - 0.007 16.2 3.2 0.007 16.2 3.2 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 PIK34249.1 - 0.03 14.6 7.7 0.03 14.6 7.7 3.5 3 2 1 4 4 4 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 PIK34249.1 - 0.037 13.8 3.8 0.037 13.8 3.8 2.4 2 0 0 2 2 2 0 RING-like zinc finger U-box PF04564.15 PIK34249.1 - 0.064 13.4 0.0 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 U-box domain IBR PF01485.21 PIK34249.1 - 7.8 6.8 21.3 4.6 7.5 5.2 3.2 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain SIP1 PF04938.12 PIK34250.1 - 2.4e-40 138.6 0.1 3e-40 138.3 0.1 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF3446 PF11928.8 PIK34251.1 - 0.018 15.3 2.4 1.2 9.5 0.1 2.7 2 1 0 2 2 2 0 Early growth response N-terminal domain TipE PF16972.5 PIK34251.1 - 0.061 12.5 0.1 0.08 12.1 0.1 1.1 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE BTB PF00651.31 PIK34252.1 - 1.3e-08 35.0 0.2 1.2e-07 31.9 0.2 2.3 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK34252.1 - 0.00039 20.5 0.1 0.0013 18.8 0.1 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch XRN_M PF17846.1 PIK34252.1 - 0.21 10.5 2.2 0.27 10.1 2.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain RCC1 PF00415.18 PIK34253.1 - 4e-28 97.8 5.3 2e-06 28.3 0.2 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK34253.1 - 1.8e-10 40.4 9.9 0.0014 18.3 0.1 5.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat Ank_5 PF13857.6 PIK34253.1 - 5.6e-10 39.3 0.0 0.00013 22.2 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) BTB PF00651.31 PIK34253.1 - 1.3e-07 31.8 1.6 2.4e-07 31.0 0.3 2.1 2 1 0 2 2 2 1 BTB/POZ domain Ank_2 PF12796.7 PIK34253.1 - 2.1e-06 28.2 0.0 2.1e-05 25.0 0.0 2.6 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK34253.1 - 9e-06 26.1 0.1 0.00013 22.5 0.0 3.0 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK34253.1 - 9.5e-06 25.6 0.0 0.0048 17.3 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 PIK34253.1 - 8.1e-05 22.9 0.0 0.012 16.1 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Glyco_transf_92 PF01697.27 PIK34254.1 - 4.3e-10 39.7 0.1 6.5e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 PIK34254.1 - 0.02 15.4 0.0 0.041 14.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Ribosomal_S15 PF00312.22 PIK34255.1 - 1e-05 25.7 6.4 1.9e-05 24.8 0.4 2.8 2 1 0 2 2 2 1 Ribosomal protein S15 FGAR-AT_linker PF18072.1 PIK34255.1 - 0.18 12.4 0.7 0.96 10.0 0.2 2.2 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3504 PF12012.8 PIK34256.1 - 2.8e-50 170.4 0.4 7e-50 169.1 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) zf-FCS PF06467.14 PIK34256.1 - 5.4e-13 48.6 36.5 0.0001 22.2 0.4 5.6 5 0 0 5 5 5 4 MYM-type Zinc finger with FCS sequence motif YHS PF04945.13 PIK34256.1 - 0.0036 17.4 11.1 0.31 11.2 0.1 4.1 4 0 0 4 4 4 2 YHS domain YHS PF04945.13 PIK34257.1 - 0.0047 17.0 23.9 0.014 15.5 1.5 3.8 4 0 0 4 4 4 2 YHS domain zf-FCS PF06467.14 PIK34257.1 - 0.055 13.4 38.8 0.059 13.3 2.0 4.8 4 2 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif XhlA PF10779.9 PIK34257.1 - 0.31 11.3 0.4 0.48 10.7 0.4 1.2 1 0 0 1 1 1 0 Haemolysin XhlA zf-MYND PF01753.18 PIK34257.1 - 0.77 9.9 23.6 2.1 8.5 0.4 4.3 1 1 1 2 2 2 0 MYND finger Ribosomal_L24e PF01246.20 PIK34257.1 - 5.4 7.3 13.2 2.5 8.4 3.9 3.5 3 1 0 3 3 3 0 Ribosomal protein L24e zf-MYND PF01753.18 PIK34258.1 - 0.0027 17.8 1.8 0.72 10.0 1.8 2.7 1 1 0 1 1 1 1 MYND finger VATC PF18716.1 PIK34258.1 - 0.059 13.2 1.0 0.059 13.2 1.0 2.3 1 1 1 2 2 2 0 Vms1-associating treble clef domain Phage_fiber_2 PF03406.13 PIK34258.1 - 0.31 10.6 2.0 1.2 8.8 0.5 2.3 2 0 0 2 2 2 0 Phage tail fibre repeat Senescence PF06911.12 PIK34258.1 - 0.81 10.0 6.0 1.2 9.5 6.0 1.3 1 0 0 1 1 1 0 Senescence-associated protein zf-FCS PF06467.14 PIK34258.1 - 1.2 9.1 22.8 0.29 11.1 10.0 3.2 2 2 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_6 PF13912.6 PIK34258.1 - 5.3 7.2 6.6 1.5 8.9 2.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger EF-hand_1 PF00036.32 PIK34259.1 - 0.03 13.9 0.0 0.068 12.8 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 PIK34259.1 - 0.071 13.1 0.0 0.22 11.6 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain Cupin_8 PF13621.6 PIK34260.1 - 1e-31 110.6 0.0 3.2e-31 109.0 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK34260.1 - 2.1e-05 24.2 0.1 3.9e-05 23.3 0.1 1.5 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 PIK34260.1 - 0.014 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_8 PF13621.6 PIK34261.1 - 3.9e-23 82.5 0.0 5.9e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK34261.1 - 0.0011 18.5 0.0 0.0017 17.9 0.0 1.5 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 PIK34261.1 - 0.015 15.0 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Cupin domain JmjC PF02373.22 PIK34261.1 - 0.028 14.8 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase 6PGD PF00393.19 PIK34262.1 - 3.4e-114 381.1 0.0 7.1e-114 380.1 0.0 1.5 2 0 0 2 2 2 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 PIK34262.1 - 1e-09 38.7 0.1 1.3e-06 28.7 0.1 2.3 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 PIK34262.1 - 0.058 13.6 0.0 0.64 10.3 0.0 2.6 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Forkhead PF00250.18 PIK34263.1 - 6.4e-38 128.9 0.2 1.2e-37 128.1 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain Mitofilin PF09731.9 PIK34263.1 - 0.16 10.8 3.5 0.21 10.4 3.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Glyco_transf_10 PF00852.19 PIK34264.1 - 8e-37 126.6 0.3 1.3e-36 126.0 0.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK34264.1 - 1.8e-10 41.2 0.0 2.8e-09 37.4 0.0 2.3 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Tub PF01167.18 PIK34265.1 - 3.5e-36 125.2 0.0 2.1e-35 122.6 0.0 1.9 1 1 0 1 1 1 1 Tub family Tub_N PF16322.5 PIK34266.1 - 0.014 15.9 6.7 0.033 14.6 6.5 1.7 2 0 0 2 2 2 0 Tubby N-terminal PIH1 PF08190.12 PIK34267.1 - 1.7e-35 122.0 0.1 2.1e-35 121.7 0.1 1.1 1 0 0 1 1 1 1 PIH1 N-terminal domain Svs_4_5_6 PF17381.2 PIK34268.1 - 0.025 15.5 0.0 0.045 14.7 0.0 1.4 1 0 0 1 1 1 0 Seminal vesicle secretory proteins 4/5/6 NACHT PF05729.12 PIK34270.1 - 8e-13 48.6 0.0 1.8e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK34270.1 - 1.5e-08 34.5 3.1 4.1e-05 23.5 0.5 3.1 2 1 1 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK34270.1 - 8.1e-07 29.2 6.6 0.051 13.8 0.3 4.7 3 1 1 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK34270.1 - 7.2e-05 23.3 6.0 0.59 10.8 0.1 4.9 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK34270.1 - 0.00057 19.9 1.0 1.5 8.9 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 PIK34270.1 - 0.033 14.6 5.1 0.032 14.6 1.5 3.0 3 0 0 3 3 2 0 Immunoglobulin C1-set domain IstB_IS21 PF01695.17 PIK34270.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Type2_restr_D3 PF16902.5 PIK34270.1 - 0.11 12.5 0.9 25 4.9 0.0 3.7 3 0 0 3 3 3 0 Type-2 restriction enzyme D3 domain CD34_antigen PF06365.12 PIK34270.1 - 0.14 11.7 1.7 0.91 9.1 0.0 2.7 3 0 0 3 3 3 0 CD34/Podocalyxin family PspB PF06667.12 PIK34270.1 - 2 8.5 3.8 32 4.7 0.0 3.2 3 0 0 3 3 3 0 Phage shock protein B ig PF00047.25 PIK34270.1 - 5.1 7.3 7.1 10 6.4 0.3 3.8 4 0 0 4 4 4 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK34271.1 - 5.5e-20 71.7 0.2 7.9e-10 38.4 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK34271.1 - 5e-07 29.4 0.0 0.013 14.8 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain DUF1622 PF07784.11 PIK34271.1 - 0.042 13.8 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1622) Ig_3 PF13927.6 PIK34272.1 - 1.2e-07 32.2 1.8 0.0018 18.8 0.4 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK34272.1 - 2.6e-06 27.4 0.3 0.019 15.0 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK34272.1 - 0.0015 18.7 0.3 1.5 9.0 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK34272.1 - 0.028 14.5 0.4 0.049 13.7 0.0 1.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK34272.1 - 0.037 13.6 0.0 0.08 12.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain NACHT PF05729.12 PIK34273.1 - 4.9e-11 42.8 0.0 1e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK34273.1 - 9.6e-06 25.9 0.0 8.2e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK34273.1 - 0.0068 16.8 0.0 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 PIK34273.1 - 0.052 13.3 0.0 0.58 9.9 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DAP3 PF10236.9 PIK34273.1 - 0.063 12.4 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TniB PF05621.11 PIK34273.1 - 0.12 11.7 0.0 0.37 10.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 PIK34273.1 - 0.16 11.9 0.0 0.48 10.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase WD40 PF00400.32 PIK34274.1 - 6.9e-25 86.8 2.1 0.0044 17.8 0.0 8.5 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK34274.1 - 1.8e-13 50.6 0.0 2.7e-05 24.4 0.0 5.1 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK34274.1 - 0.00074 19.4 0.0 0.062 13.2 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 PIK34274.1 - 0.0024 17.5 0.0 0.018 14.6 0.0 2.2 1 1 0 2 2 2 1 PQQ-like domain PD40 PF07676.12 PIK34274.1 - 0.0056 16.6 0.0 10 6.2 0.0 4.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 PIK34274.1 - 0.06 12.3 0.0 0.12 11.4 0.0 1.7 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HEAT_EZ PF13513.6 PIK34275.1 - 6.5e-05 23.3 0.1 0.049 14.2 0.0 4.1 4 1 1 5 5 4 1 HEAT-like repeat Cnd1 PF12717.7 PIK34275.1 - 0.001 19.1 1.3 0.28 11.2 0.2 2.8 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK34275.1 - 0.0015 18.8 0.2 0.27 11.6 0.1 3.3 1 1 2 3 3 3 2 HEAT repeats CENP-B_dimeris PF09026.10 PIK34275.1 - 0.0028 18.0 5.0 0.0094 16.3 5.1 1.8 2 0 0 2 2 2 1 Centromere protein B dimerisation domain RICTOR_N PF14664.6 PIK34275.1 - 0.0054 15.8 0.5 0.012 14.7 0.5 1.7 1 1 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term HEAT PF02985.22 PIK34275.1 - 0.015 15.5 0.2 21 5.7 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat Arm PF00514.23 PIK34275.1 - 0.027 14.5 2.2 42 4.4 0.1 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Ribosomal_L30 PF00327.20 PIK34275.1 - 0.047 13.6 0.1 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein L30p/L7e V-ATPase_H_N PF03224.14 PIK34275.1 - 0.05 12.9 0.3 0.1 11.9 0.3 1.6 1 1 0 1 1 1 0 V-ATPase subunit H Proteasom_PSMB PF10508.9 PIK34275.1 - 0.1 11.1 0.5 0.44 9.0 0.2 1.9 1 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit RIX1 PF08167.12 PIK34275.1 - 0.11 12.2 0.2 8.7 6.0 0.0 2.6 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis RRN3 PF05327.11 PIK34275.1 - 0.43 9.1 2.4 0.6 8.6 2.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 PIK34275.1 - 3.4 6.9 6.8 5 6.3 6.8 1.2 1 0 0 1 1 1 0 NOA36 protein Pro_isomerase PF00160.21 PIK34276.1 - 6e-42 143.6 0.1 7.7e-42 143.3 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ponericin PF07442.11 PIK34276.1 - 0.13 12.3 0.7 4.2 7.5 0.0 2.5 3 0 0 3 3 3 0 Ponericin CSD PF00313.22 PIK34277.1 - 1.8e-23 82.2 0.3 2.9e-23 81.5 0.3 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 PIK34277.1 - 0.0068 16.1 0.3 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 Ribonuclease B OB domain ig PF00047.25 PIK34278.1 - 3.6e-10 39.9 5.3 7e-08 32.5 0.4 3.6 3 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK34278.1 - 3.9e-10 40.2 2.4 4.4e-06 27.2 0.1 3.7 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK34278.1 - 1e-08 35.3 4.1 3.3e-08 33.7 0.1 3.1 4 0 0 4 4 4 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK34278.1 - 3.4e-08 33.7 0.5 0.015 15.6 0.1 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK34278.1 - 6.6e-08 32.5 0.8 1.5e-06 28.1 0.0 2.9 3 1 0 3 3 3 1 Immunoglobulin I-set domain Ig_6 PF18452.1 PIK34278.1 - 0.0036 16.8 0.0 0.0077 15.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Trp_oprn_chp PF09534.10 PIK34278.1 - 0.042 13.6 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Gal_Lectin PF02140.18 PIK34278.1 - 0.086 13.3 0.4 16 6.0 0.2 2.7 2 1 0 2 2 2 0 Galactose binding lectin domain C2-set_2 PF08205.12 PIK34278.1 - 0.11 12.5 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain SID-1_RNA_chan PF13965.6 PIK34278.1 - 0.13 10.7 0.2 0.2 10.0 0.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BpuSI_N PF15516.6 PIK34279.1 - 0.011 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 BpuSI N-terminal domain Radical_SAM PF04055.21 PIK34280.1 - 2.5e-18 67.0 0.0 6.1e-18 65.7 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 PIK34280.1 - 0.093 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S single cluster domain TPR_12 PF13424.6 PIK34281.1 - 4.5e-10 39.7 1.7 0.00045 20.5 0.6 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK34281.1 - 7.5e-05 22.5 0.6 1.8 8.6 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK34281.1 - 0.00063 19.7 4.5 0.032 14.3 0.0 3.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK34281.1 - 0.0027 17.4 4.8 0.091 12.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.14 PIK34281.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit SbcCD_C PF13558.6 PIK34281.1 - 0.071 13.4 0.2 0.16 12.2 0.1 1.6 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TPR_8 PF13181.6 PIK34281.1 - 1.8 8.9 4.6 13 6.3 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat CCDC14 PF15254.6 PIK34282.1 - 2.2e-24 86.2 40.9 7.5e-24 84.5 41.1 1.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 14 CCDC14 PF15254.6 PIK34283.1 - 0.00092 18.0 6.1 0.0011 17.8 6.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 FA_desaturase PF00487.24 PIK34284.1 - 5.1e-33 115.0 18.4 7.6e-33 114.4 18.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 PIK34284.1 - 4.7e-24 84.3 0.1 8.7e-24 83.5 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Voltage_CLC PF00654.20 PIK34284.1 - 0.07 12.4 2.1 0.095 11.9 2.1 1.2 1 0 0 1 1 1 0 Voltage gated chloride channel Cyclin_N PF00134.23 PIK34285.1 - 2.5e-07 30.5 1.4 5.5e-07 29.4 0.1 2.2 2 1 0 3 3 3 1 Cyclin, N-terminal domain Cyclin PF08613.11 PIK34285.1 - 3.5e-05 24.2 0.3 6.5e-05 23.4 0.3 1.5 1 0 0 1 1 1 1 Cyclin MukF_C PF17193.4 PIK34285.1 - 0.049 13.8 0.1 6.2 6.9 0.0 2.4 2 0 0 2 2 2 0 MukF C-terminal domain Med13_N PF11597.8 PIK34286.1 - 1.8e-09 37.4 1.5 1e-08 34.9 0.0 2.2 1 1 1 2 2 2 1 Mediator complex subunit 13 N-terminal SUIM_assoc PF16619.5 PIK34286.1 - 0.00064 19.7 6.2 0.0028 17.7 6.2 2.3 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 PIK34286.1 - 0.038 13.6 8.7 0.074 12.6 8.7 1.5 1 0 0 1 1 1 0 Spt20 family MID_MedPIWI PF18296.1 PIK34287.1 - 6.7e-30 104.7 1.0 5.7e-29 101.6 0.0 2.2 2 0 0 2 2 2 1 MID domain of medPIWI DUF4407 PF14362.6 PIK34287.1 - 1.1 8.6 3.1 1.6 8.1 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med13_C PF06333.12 PIK34288.1 - 4.1e-52 177.5 0.0 6.6e-52 176.8 0.0 1.3 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 PIK34288.1 - 2.8e-27 96.1 0.0 4.4e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 MID domain of medPIWI Med13_C PF06333.12 PIK34289.1 - 2.6e-07 30.2 0.1 3.1e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain Kunitz_BPTI PF00014.23 PIK34290.1 - 2.8e-47 158.7 36.5 7.3e-18 64.6 4.7 4.9 4 0 0 4 4 4 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Kazal_1 PF00050.21 PIK34290.1 - 1.6e-26 92.1 63.5 5.3e-10 39.2 6.2 6.6 6 0 0 6 6 6 4 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK34290.1 - 9.2e-17 60.9 34.6 4.8e-07 29.8 2.0 8.0 10 0 0 10 10 10 4 Kazal-type serine protease inhibitor domain TIMP PF00965.17 PIK34291.1 - 2.8e-14 53.4 5.7 3.6e-14 53.0 5.7 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase LCM PF04072.14 PIK34292.1 - 1.8e-28 99.8 0.0 2.7e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 PIK34292.1 - 7.3e-23 80.3 4.6 2.1e-07 30.8 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK34292.1 - 4e-19 68.2 3.4 2.9e-08 33.7 0.0 5.6 4 1 2 6 6 6 4 Kelch motif Kelch_3 PF13415.6 PIK34292.1 - 2e-18 66.2 1.7 0.0023 18.2 0.0 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK34292.1 - 6.7e-13 48.3 0.0 0.023 14.7 0.0 6.6 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 PIK34292.1 - 2.3e-06 27.1 0.1 0.12 12.0 0.0 4.6 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 PIK34292.1 - 8e-05 22.5 0.9 1.5 8.9 0.1 4.7 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.14 PIK34292.1 - 0.0065 15.5 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Recombination activating protein 2 bZIP_1 PF00170.21 PIK34293.1 - 5.3e-19 68.1 14.3 5.3e-19 68.1 14.3 2.2 2 0 0 2 2 2 1 bZIP transcription factor pKID PF02173.17 PIK34293.1 - 3.1e-11 42.5 1.0 3.1e-11 42.5 1.0 1.7 2 0 0 2 2 2 1 pKID domain bZIP_2 PF07716.15 PIK34293.1 - 5.3e-07 29.6 14.0 5.3e-07 29.6 14.0 2.1 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 PIK34293.1 - 0.0023 18.4 6.9 0.0059 17.1 6.9 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 PIK34293.1 - 0.0075 15.9 1.4 0.0075 15.9 1.4 1.8 2 0 0 2 2 2 1 Apx/Shroom domain ASD2 TPR_MLP1_2 PF07926.12 PIK34293.1 - 0.018 15.1 6.5 0.046 13.8 6.5 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Phage_Gp23 PF10669.9 PIK34293.1 - 1 9.7 9.1 0.18 12.2 3.3 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) OSR1_C PF12202.8 PIK34294.1 - 1.3e-22 79.8 0.3 3.3e-22 78.5 0.3 1.7 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase PF00069.25 PIK34294.1 - 5.5e-16 58.7 0.0 7.2e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34294.1 - 6.9e-12 45.2 0.0 1.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34295.1 - 2.2e-24 86.3 0.5 2.1e-13 50.3 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34295.1 - 2.8e-16 59.6 0.5 3.8e-16 59.2 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK34295.1 - 0.037 12.8 0.0 0.067 12.0 0.0 1.3 1 1 0 1 1 1 0 Fungal protein kinase LRR19-TM PF15176.6 PIK34296.1 - 0.0029 17.6 0.5 0.0059 16.6 0.0 1.7 2 0 0 2 2 2 1 Leucine-rich repeat family 19 TM domain LapA_dom PF06305.11 PIK34296.1 - 0.077 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF3533 PF12051.8 PIK34296.1 - 0.082 11.8 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Collectrin PF16959.5 PIK34296.1 - 0.083 12.7 0.8 0.14 12.0 0.8 1.3 1 0 0 1 1 1 0 Renal amino acid transporter Integrin_alpha PF00357.20 PIK34296.1 - 0.11 12.6 1.2 0.12 12.5 0.1 1.7 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region Adeno_E3_CR2 PF02439.15 PIK34296.1 - 0.27 11.0 2.1 0.49 10.2 2.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.20 PIK34296.1 - 0.52 10.3 2.0 1 9.3 2.0 1.4 1 0 0 1 1 1 0 Syndecan domain Tudor_3 PF18115.1 PIK34297.1 - 0.03 14.2 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain DUF1890 PF09001.11 PIK34297.1 - 0.086 13.2 0.9 0.13 12.6 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1890) Jagunal PF07086.12 PIK34297.1 - 0.44 10.6 2.3 0.73 9.9 2.3 1.3 1 0 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis Phage_holin_3_6 PF07332.11 PIK34297.1 - 0.6 10.2 3.5 0.39 10.8 0.1 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3112 PF11309.8 PIK34297.1 - 0.82 9.1 6.3 0.88 9.0 4.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) PhoLip_ATPase_C PF16212.5 PIK34297.1 - 0.94 9.2 6.2 1.6 8.4 6.2 1.4 1 1 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal 7tm_1 PF00001.21 PIK34298.1 - 2.2e-13 50.2 20.0 3.1e-13 49.7 20.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FixP_N PF14715.6 PIK34298.1 - 0.011 15.4 0.1 0.011 15.4 0.1 2.6 3 0 0 3 3 3 0 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF5527 PF17665.1 PIK34298.1 - 0.071 12.6 0.2 0.17 11.4 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5527) 7tm_1 PF00001.21 PIK34299.1 - 1e-10 41.4 13.5 1e-10 41.4 13.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DAO PF01266.24 PIK34300.1 - 3e-55 188.2 2.4 5.9e-48 164.2 0.3 2.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK34300.1 - 0.0011 18.2 0.0 0.0027 17.0 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK34300.1 - 0.0013 18.0 0.5 0.0059 15.9 0.1 2.0 2 0 0 2 2 2 1 Thi4 family Trp_halogenase PF04820.14 PIK34300.1 - 0.006 15.5 0.1 0.091 11.6 0.0 2.0 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 PIK34300.1 - 0.015 14.5 0.1 0.048 12.9 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK34300.1 - 0.034 14.7 0.0 0.083 13.5 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK34300.1 - 0.039 13.2 0.6 0.1 11.8 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 PIK34300.1 - 0.043 13.5 0.1 0.073 12.7 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 PIK34300.1 - 0.098 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 ThiF family GMC_oxred_N PF00732.19 PIK34300.1 - 0.098 12.0 0.1 12 5.2 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase GCV_T PF01571.21 PIK34301.1 - 1.2e-53 182.1 0.0 1.7e-53 181.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 PIK34301.1 - 1.9e-10 40.9 0.2 1.9e-09 37.7 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase central domain SoxG PF04268.12 PIK34301.1 - 3.4e-06 27.3 0.0 7.4e-06 26.2 0.0 1.5 1 1 0 1 1 1 1 Sarcosine oxidase, gamma subunit family UPF0184 PF03670.13 PIK34302.1 - 1.2e-09 38.4 4.2 1.5e-09 38.1 4.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) ZapB PF06005.12 PIK34302.1 - 0.013 16.0 0.6 0.016 15.6 0.6 1.2 1 0 0 1 1 1 0 Cell division protein ZapB HALZ PF02183.18 PIK34302.1 - 0.033 14.4 0.6 0.052 13.8 0.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper CLZ PF16526.5 PIK34302.1 - 0.04 14.3 0.3 0.072 13.5 0.3 1.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 PIK34302.1 - 0.043 13.9 3.0 0.049 13.7 3.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 PIK34302.1 - 0.14 12.4 0.2 0.2 11.9 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DEAD PF00270.29 PIK34303.1 - 9.7e-35 119.9 0.1 1.8e-34 119.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK34303.1 - 2.4e-25 89.0 0.8 3.9e-23 81.9 0.1 2.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 PIK34303.1 - 1.5e-07 31.6 0.1 3e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 PIK34303.1 - 0.012 15.0 0.1 0.02 14.3 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Acyl-CoA_dh_1 PF00441.24 PIK34304.1 - 1.9e-20 73.6 0.4 3.1e-20 72.9 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK34304.1 - 1.4e-13 51.4 0.2 1.1e-12 48.6 0.2 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK34304.1 - 3.1e-10 40.5 0.7 4.9e-10 39.8 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain FMP23 PF17315.2 PIK34304.1 - 0.023 14.8 0.0 0.037 14.2 0.0 1.2 1 0 0 1 1 1 0 Found in mitochondrial proteome LIM PF00412.22 PIK34305.1 - 2.4e-13 50.1 4.6 2.8e-13 49.9 4.6 1.1 1 0 0 1 1 1 1 LIM domain zf-FLZ PF04570.14 PIK34305.1 - 0.02 14.4 2.5 1.6 8.2 0.9 2.3 1 1 1 2 2 2 0 zinc-finger of the FCS-type, C2-C2 NCD3G PF07562.14 PIK34305.1 - 0.034 14.1 2.3 0.046 13.7 2.3 1.4 1 1 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR zf-FCS PF06467.14 PIK34305.1 - 0.036 14.0 3.6 0.049 13.6 0.8 2.2 2 1 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Vps39_2 PF10367.9 PIK34305.1 - 0.037 14.5 2.0 0.14 12.6 0.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 FXa_inhibition PF14670.6 PIK34306.1 - 4.9e-12 45.9 4.7 4.9e-12 45.9 4.7 3.3 2 1 1 3 3 3 2 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 PIK34306.1 - 2.8e-11 43.4 9.5 3e-11 43.3 8.0 1.9 1 1 0 1 1 1 1 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK34306.1 - 0.014 15.9 0.1 1.7 9.2 0.1 2.4 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 PIK34307.1 - 2.2e-08 34.2 8.5 2.2e-08 34.2 8.5 3.7 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK34307.1 - 1.8e-07 31.5 0.0 0.0014 19.1 0.0 2.7 2 1 0 2 2 2 2 Low-density lipoprotein receptor repeat class B cEGF PF12662.7 PIK34307.1 - 3e-07 30.2 1.7 3e-07 30.2 1.7 3.7 3 1 0 3 3 3 1 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK34307.1 - 4.6e-07 29.9 6.2 4.6e-07 29.9 6.2 3.6 2 1 1 3 3 3 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK34307.1 - 1.2e-06 28.7 32.6 5.3e-06 26.6 5.5 3.3 2 1 0 2 2 2 2 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 PIK34307.1 - 0.036 14.4 10.6 1.2 9.5 0.4 2.8 2 0 0 2 2 2 0 Pvs28 EGF domain EGF_3 PF12947.7 PIK34307.1 - 1.2 9.4 25.1 0.26 11.5 3.6 3.8 2 2 0 2 2 2 0 EGF domain TMEM154 PF15102.6 PIK34308.1 - 3.5e-05 23.7 0.4 5.1e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 TMEM154 protein family Amnionless PF14828.6 PIK34308.1 - 9.7e-05 21.4 0.0 0.00011 21.2 0.0 1.1 1 0 0 1 1 1 1 Amnionless EphA2_TM PF14575.6 PIK34308.1 - 0.0026 18.6 0.0 0.0032 18.3 0.0 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Oxidored_q2 PF00420.24 PIK34308.1 - 0.0037 16.9 0.0 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Orf78 PF06024.12 PIK34308.1 - 0.0049 17.2 0.1 0.0079 16.5 0.1 1.3 1 0 0 1 1 1 1 Orf78 (ac78) WSS_VP PF12175.8 PIK34308.1 - 0.013 15.0 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP DUF2207 PF09972.9 PIK34308.1 - 0.03 13.1 0.0 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SP_C-Propep PF08999.10 PIK34308.1 - 0.036 13.8 0.4 0.092 12.5 0.5 1.6 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide NB PF04159.13 PIK34308.1 - 0.042 13.9 2.6 0.066 13.3 2.6 1.3 1 0 0 1 1 1 0 NB glycoprotein DUF3827 PF12877.7 PIK34308.1 - 0.069 11.5 2.4 0.092 11.1 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF3377 PF11857.8 PIK34308.1 - 0.078 12.9 1.8 0.13 12.2 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ASFV_J13L PF05568.11 PIK34308.1 - 0.08 12.7 0.3 0.13 12.0 0.3 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein Protocadherin PF08374.11 PIK34308.1 - 0.082 12.9 0.0 0.098 12.6 0.0 1.2 1 0 0 1 1 1 0 Protocadherin Syndecan PF01034.20 PIK34308.1 - 0.24 11.3 2.1 0.52 10.3 2.1 1.5 1 0 0 1 1 1 0 Syndecan domain RIFIN PF02009.16 PIK34308.1 - 0.28 11.1 1.6 0.37 10.6 1.6 1.1 1 0 0 1 1 1 0 Rifin Sigma_reg_N PF13800.6 PIK34308.1 - 0.31 11.4 2.7 0.33 11.3 0.9 1.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal NCU-G1 PF15065.6 PIK34308.1 - 0.35 9.8 1.4 0.56 9.1 1.4 1.3 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 RCR PF12273.8 PIK34308.1 - 0.65 10.7 2.4 1.8 9.3 2.4 1.8 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Shisa PF13908.6 PIK34308.1 - 0.89 9.8 3.0 0.9 9.7 2.7 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Baculo_11_kDa PF06143.11 PIK34308.1 - 1.1 8.9 4.6 1.7 8.3 4.6 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family Ldl_recept_b PF00058.17 PIK34309.1 - 3.5e-14 53.0 0.1 7.9e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 PIK34309.1 - 3.4e-11 43.2 30.0 4e-07 30.1 14.0 4.1 3 2 1 4 4 4 2 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK34309.1 - 6.2e-08 32.4 4.6 0.00095 19.0 0.2 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK34309.1 - 1.9e-06 28.0 7.2 1.9e-06 28.0 7.2 4.8 2 1 2 4 4 4 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK34309.1 - 4.5e-05 23.6 5.4 4.5e-05 23.6 5.4 3.7 3 1 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK34309.1 - 0.044 14.0 4.7 0.044 14.0 4.7 4.1 2 1 0 2 2 2 0 EGF domain PDZ PF00595.24 PIK34310.1 - 3.5e-07 30.5 0.0 8e-07 29.3 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK34310.1 - 0.00032 20.5 0.0 0.00078 19.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain adh_short PF00106.25 PIK34311.1 - 2.9e-18 66.1 0.0 5e-18 65.3 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK34311.1 - 5.2e-07 29.5 0.0 7.4e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TK PF00265.18 PIK34313.1 - 0.11 12.4 3.3 0.078 12.8 1.0 1.7 1 1 1 2 2 2 0 Thymidine kinase TOH_N PF12549.8 PIK34313.1 - 0.61 10.0 2.2 27 4.8 0.2 2.3 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal NTP_transf_2 PF01909.23 PIK34314.1 - 6.6e-06 26.3 0.0 3.7e-05 23.9 0.0 2.2 1 1 0 1 1 1 1 Nucleotidyltransferase domain RRM_1 PF00076.22 PIK34314.1 - 0.11 12.3 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.17 PIK34317.1 - 5e-28 98.1 0.1 6e-28 97.8 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34317.1 - 2.8e-07 30.2 0.0 3.4e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Transposase_21 PF02992.14 PIK34318.1 - 1.5e-10 40.7 0.1 2.6e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Transposase family tnp2 zf-RING_5 PF14634.6 PIK34318.1 - 0.1 12.6 3.4 0.31 11.0 0.9 2.4 2 0 0 2 2 2 0 zinc-RING finger domain A2L_zn_ribbon PF08792.10 PIK34318.1 - 0.56 10.0 3.3 0.48 10.2 0.6 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain WSC PF01822.19 PIK34319.1 - 2.7e-20 72.3 23.5 1.9e-10 40.8 9.3 2.2 2 0 0 2 2 2 2 WSC domain DUF4953 PF16313.5 PIK34319.1 - 0.29 10.3 0.0 0.44 9.7 0.0 1.2 1 0 0 1 1 1 0 Met-zincin WSC PF01822.19 PIK34320.1 - 2.6e-22 78.8 23.8 1.2e-12 47.9 8.5 2.2 2 0 0 2 2 2 2 WSC domain Methyltransf_25 PF13649.6 PIK34321.1 - 1.2e-05 25.9 0.0 2.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34321.1 - 0.00011 22.8 0.0 0.00019 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK34321.1 - 0.00039 21.1 0.0 0.0007 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34321.1 - 0.0027 17.5 0.0 0.0043 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK34321.1 - 0.0096 15.4 0.0 0.022 14.2 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_32 PF13679.6 PIK34321.1 - 0.075 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK34321.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sulfatase PF00884.23 PIK34322.1 - 7.4e-81 271.9 0.0 2.5e-80 270.2 0.0 1.7 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 PIK34322.1 - 3.8e-25 89.0 1.9 7.1e-25 88.1 1.9 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK34322.1 - 5.5e-08 32.8 0.4 2.1e-07 30.9 0.0 1.9 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase IQ PF00612.27 PIK34323.1 - 6.7e-12 44.1 15.1 4.1e-05 23.0 1.4 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF1481 PF07356.12 PIK34323.1 - 8.3 6.1 9.3 1.5 8.5 0.8 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1481) Sulfatase_C PF14707.6 PIK34324.1 - 0.0053 17.5 0.0 0.006 17.3 0.0 1.1 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 PIK34324.1 - 0.0081 16.0 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function Tetraspanin PF00335.20 PIK34325.1 - 5.9e-51 173.4 19.8 6.7e-51 173.2 19.8 1.0 1 0 0 1 1 1 1 Tetraspanin family Tetraspanin PF00335.20 PIK34326.1 - 4.2e-33 115.0 19.5 2.2e-30 106.1 6.3 2.0 1 1 1 2 2 2 2 Tetraspanin family EI24 PF07264.11 PIK34326.1 - 0.026 14.8 0.9 0.34 11.1 0.9 2.2 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF1206 PF06724.11 PIK34326.1 - 0.13 12.3 0.6 0.13 12.3 0.6 3.2 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1206) SKG6 PF08693.10 PIK34326.1 - 8.9 5.8 9.8 0.28 10.6 1.6 2.7 3 0 0 3 3 3 0 Transmembrane alpha-helix domain Tetraspanin PF00335.20 PIK34327.1 - 1.8e-48 165.3 17.3 2e-48 165.1 17.3 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF4834 PF16118.5 PIK34327.1 - 0.95 10.5 0.0 0.95 10.5 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Tetraspanin PF00335.20 PIK34328.1 - 2.7e-23 82.9 2.5 3.1e-23 82.7 2.5 1.0 1 0 0 1 1 1 1 Tetraspanin family CM2 PF03021.14 PIK34328.1 - 0.062 13.1 0.4 0.12 12.1 0.2 1.6 1 1 1 2 2 2 0 Influenza C virus M2 protein RVT_1 PF00078.27 PIK34329.1 - 7.9e-28 97.5 0.1 1.9e-27 96.2 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK34329.1 - 1.3e-27 95.7 0.0 2.3e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34329.1 - 5.1e-25 87.8 0.0 8.4e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK34330.1 - 2.2e-20 73.1 0.0 5.8e-19 68.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK34330.1 - 0.00018 21.2 0.1 0.0015 18.2 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain Exo_endo_phos PF03372.23 PIK34331.1 - 2.7e-08 33.6 0.0 3.5e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family adh_short PF00106.25 PIK34332.1 - 3.5e-35 121.2 2.1 4.5e-35 120.9 2.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK34332.1 - 1.4e-28 100.1 1.7 2.4e-28 99.3 1.7 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK34332.1 - 1.1e-08 35.2 0.2 1.7e-08 34.6 0.2 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK34332.1 - 2.5e-05 23.9 0.2 3.1e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK34332.1 - 4.8e-05 22.6 0.1 9.1e-05 21.7 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK34332.1 - 5.5e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 PIK34332.1 - 0.038 14.2 1.1 0.21 11.8 0.2 2.2 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain LppC PF04348.13 PIK34332.1 - 0.069 11.9 0.0 0.069 11.9 0.0 1.1 1 0 0 1 1 1 0 LppC putative lipoprotein NmrA PF05368.13 PIK34332.1 - 0.082 12.4 0.2 0.19 11.3 0.2 1.8 1 1 0 1 1 1 0 NmrA-like family Synaptobrevin PF00957.21 PIK34333.1 - 0.057 13.2 0.5 0.096 12.5 0.3 1.6 1 1 0 1 1 1 0 Synaptobrevin Claudin_2 PF13903.6 PIK34333.1 - 0.22 11.2 0.0 0.22 11.2 0.0 2.0 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction RIFIN PF02009.16 PIK34334.1 - 0.017 15.1 0.1 0.017 15.1 0.1 1.7 2 0 0 2 2 2 0 Rifin TMEM154 PF15102.6 PIK34334.1 - 0.022 14.7 1.5 0.022 14.7 1.5 2.6 1 1 0 2 2 2 0 TMEM154 protein family ODV-E18 PF10717.9 PIK34334.1 - 0.11 12.4 4.0 0.25 11.3 4.0 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Protocadherin PF08374.11 PIK34334.1 - 0.28 11.2 1.6 0.55 10.2 1.6 1.4 1 1 0 1 1 1 0 Protocadherin Orf78 PF06024.12 PIK34334.1 - 0.94 9.8 4.9 0.43 10.9 1.2 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Endomucin PF07010.12 PIK34334.1 - 1.4 8.8 8.3 0.29 11.1 3.3 2.0 2 0 0 2 2 2 0 Endomucin HMG_box PF00505.19 PIK34336.1 - 1.2e-22 80.0 0.1 2e-22 79.4 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK34336.1 - 2.8e-08 34.2 0.1 5.1e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 HMG-box domain CLCA PF08434.11 PIK34337.1 - 3.9e-10 39.5 0.0 8e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal UN_NPL4 PF11543.8 PIK34338.1 - 0.086 13.3 0.1 0.29 11.7 0.1 1.9 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Sigma70_r2 PF04542.14 PIK34338.1 - 0.13 12.0 0.0 0.74 9.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-70 region 2 GTP_EFTU PF00009.27 PIK34341.1 - 6.1e-23 81.4 0.0 1e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 PIK34341.1 - 0.0065 16.5 0.3 0.33 11.0 0.3 2.4 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK34341.1 - 0.042 13.9 0.1 0.12 12.5 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 PIK34341.1 - 0.095 12.5 0.0 2.1 8.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain LRR_8 PF13855.6 PIK34342.1 - 2.3e-28 97.7 23.7 1.7e-09 37.3 0.4 4.4 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK34342.1 - 5.8e-11 42.5 32.2 7.3e-06 26.2 0.7 5.7 1 1 7 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK34342.1 - 1e-07 31.6 5.5 2.4e-05 23.9 1.1 3.1 2 2 1 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.6 PIK34342.1 - 2.5e-06 27.5 0.0 0.025 14.6 0.0 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK34342.1 - 0.12 12.5 0.1 0.12 12.5 0.1 4.7 5 0 0 5 5 5 0 Leucine Rich repeat Arm PF00514.23 PIK34347.1 - 1.7e-16 59.6 1.4 0.0032 17.5 0.0 6.2 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK34347.1 - 2.1e-16 60.1 7.1 1.4e-07 31.7 1.8 3.8 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 PIK34347.1 - 9e-16 56.6 6.6 0.0026 17.9 0.0 7.3 8 0 0 8 8 8 3 HEAT repeat Cnd1 PF12717.7 PIK34347.1 - 3.3e-14 53.2 7.7 0.00033 20.7 0.1 4.3 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK34347.1 - 3.6e-08 33.8 10.3 0.039 14.5 0.3 6.3 5 2 1 6 6 6 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK34347.1 - 3.1e-07 30.9 0.3 0.084 13.5 0.0 3.6 1 1 3 4 4 4 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 PIK34347.1 - 3.1e-07 29.3 3.6 3.2e-06 26.0 3.6 2.0 1 1 0 1 1 1 1 Adaptin N terminal region MMS19_N PF14500.6 PIK34347.1 - 3.7e-06 26.7 0.6 0.01 15.4 0.0 3.4 4 0 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II CLASP_N PF12348.8 PIK34347.1 - 5.3e-05 22.9 0.4 2 7.9 0.0 4.6 1 1 3 4 4 4 1 CLASP N terminal Arm_2 PF04826.13 PIK34347.1 - 0.0031 17.0 0.1 0.44 10.0 0.1 2.4 1 1 1 2 2 2 1 Armadillo-like RTP1_C1 PF10363.9 PIK34347.1 - 0.0045 17.2 1.2 2.7 8.2 0.1 2.8 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 PIK34347.1 - 0.051 12.9 0.0 0.43 9.8 0.1 2.2 1 1 0 2 2 2 0 V-ATPase subunit H IFRD PF05004.13 PIK34347.1 - 0.058 12.5 5.7 1.2 8.1 0.3 3.4 2 2 1 3 3 3 0 Interferon-related developmental regulator (IFRD) Tti2 PF10521.9 PIK34347.1 - 0.064 12.8 0.2 1.1 8.7 0.1 2.8 2 1 1 3 3 3 0 Tti2 family MMS19_C PF12460.8 PIK34347.1 - 0.13 11.3 2.8 2.2 7.3 0.2 3.0 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal Nipped-B_C PF12830.7 PIK34347.1 - 0.15 12.0 0.3 46 3.9 0.0 3.2 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus DUF2019 PF09450.10 PIK34347.1 - 0.19 11.7 1.0 6.7 6.7 0.0 3.4 2 1 1 4 4 4 0 Domain of unknown function (DUF2019) Cohesin_HEAT PF12765.7 PIK34347.1 - 0.36 11.2 2.4 0.76 10.1 0.8 2.4 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion CARD_2 PF16739.5 PIK34348.1 - 0.0015 18.5 0.3 0.0024 17.8 0.3 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Amidase_2 PF01510.25 PIK34349.1 - 4.7e-16 59.4 0.1 7.8e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase 7tm_1 PF00001.21 PIK34350.1 - 2.4e-31 109.0 5.8 3e-31 108.7 5.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK34350.1 - 2.4e-14 53.6 10.1 3e-14 53.3 10.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK34350.1 - 2.6e-08 33.6 11.8 4.8e-08 32.7 11.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK34350.1 - 4.4e-06 26.3 5.1 6.3e-06 25.8 5.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.8 PIK34350.1 - 0.0052 16.6 13.1 0.0088 15.8 13.1 1.3 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 PIK34351.1 - 3.1e-31 108.7 5.9 3.9e-31 108.3 5.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK34351.1 - 2e-14 53.9 9.8 2.7e-14 53.5 9.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK34351.1 - 7.6e-08 32.0 13.8 2.4e-07 30.4 13.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK34351.1 - 1.4e-05 24.6 5.6 1.9e-05 24.2 5.4 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.8 PIK34351.1 - 0.0057 16.5 12.9 0.0095 15.7 12.9 1.3 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 SET PF00856.28 PIK34352.1 - 9e-12 45.7 0.0 9e-12 45.7 0.0 3.6 2 2 0 3 3 3 1 SET domain SUI1 PF01253.22 PIK34353.1 - 0.12 13.0 0.0 0.4 11.2 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor SUI1 SNCAIP_SNCA_bd PF16700.5 PIK34353.1 - 0.15 11.8 0.5 0.77 9.5 0.0 2.1 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain GARP PF16731.5 PIK34354.1 - 0.13 11.9 0.0 1.9 8.1 0.0 2.1 1 1 1 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma 7tm_1 PF00001.21 PIK34355.1 - 5.1e-37 127.6 4.9 7.1e-37 127.1 4.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK34355.1 - 1.2e-13 51.3 15.3 1.2e-13 51.3 15.3 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK34355.1 - 5.1e-07 29.3 13.2 8e-07 28.7 6.8 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK34355.1 - 1.2e-06 28.1 9.5 1.2e-06 28.1 9.5 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 PIK34355.1 - 0.018 14.8 12.2 0.036 13.8 12.2 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Virul_fac_BrkB PF03631.15 PIK34355.1 - 1.4 8.4 17.4 0.16 11.6 9.6 2.6 2 1 1 3 3 3 0 Virulence factor BrkB Pkinase PF00069.25 PIK34356.1 - 2.8e-67 226.9 0.1 3.6e-67 226.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34356.1 - 3.6e-38 131.3 0.0 4.7e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK34356.1 - 1.9e-05 24.1 0.0 3.2e-05 23.4 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK34356.1 - 6.6e-05 21.9 0.0 0.00011 21.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK34356.1 - 0.013 14.4 0.1 0.025 13.6 0.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 PIK34356.1 - 0.018 14.4 0.1 0.034 13.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family G-patch PF01585.23 PIK34357.1 - 2.2e-12 46.6 1.2 5.3e-12 45.4 1.2 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK34357.1 - 0.00082 19.4 2.0 0.00082 19.4 2.0 2.9 3 0 0 3 3 3 1 G-patch domain START PF01852.19 PIK34358.1 - 4.4e-14 52.4 0.1 7.3e-14 51.7 0.1 1.3 1 0 0 1 1 1 1 START domain 7tm_1 PF00001.21 PIK34359.1 - 7.4e-17 61.5 0.0 8.3e-17 61.4 0.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 PIK34359.1 - 0.83 10.0 4.3 1.2 9.4 2.2 2.2 2 1 1 3 3 3 0 Orf78 (ac78) 7tm_1 PF00001.21 PIK34360.1 - 1.5e-38 132.6 4.4 2e-38 132.3 4.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK34360.1 - 4.5e-09 36.1 5.1 6e-09 35.6 5.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK34360.1 - 2.6e-06 27.3 3.0 3.4e-06 26.9 3.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK34360.1 - 0.00011 22.1 3.2 0.00015 21.6 3.2 1.2 1 0 0 1 1 1 1 Olfactory receptor UPF0259 PF06790.11 PIK34360.1 - 0.0083 15.9 3.7 0.0083 15.9 3.7 1.7 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0259) 7tm_1 PF00001.21 PIK34361.1 - 3.2e-19 69.3 0.1 5.9e-19 68.4 0.0 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF1759 PF03564.15 PIK34363.1 - 1.7e-09 37.8 0.0 3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) ArnB_C PF18677.1 PIK34363.1 - 0.32 11.1 4.5 0.7 10.0 4.5 1.6 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain zf-CCHC PF00098.23 PIK34363.1 - 0.77 9.9 7.2 1.1 9.5 0.8 2.6 2 0 0 2 2 2 0 Zinc knuckle IFP_35_N PF07334.13 PIK34363.1 - 1.4 9.1 5.2 4.4 7.5 5.2 1.9 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus FtsL PF04999.13 PIK34363.1 - 2.7 8.0 5.9 6.8 6.8 5.9 1.6 1 0 0 1 1 1 0 Cell division protein FtsL eIF3g PF12353.8 PIK34363.1 - 3.8 7.9 10.3 1.1 9.6 0.1 3.0 1 1 2 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G Arb2 PF09757.9 PIK34364.1 - 0.25 10.4 0.0 0.35 10.0 0.0 1.1 1 0 0 1 1 1 0 Arb2 domain Phage_integrase PF00589.22 PIK34367.1 - 7.9e-05 22.5 0.1 0.034 13.9 0.0 2.4 1 1 1 2 2 2 2 Phage integrase family Integrase_1 PF12835.7 PIK34367.1 - 0.055 13.6 0.2 0.15 12.2 0.1 1.7 2 0 0 2 2 2 0 Integrase Nucleotid_trans PF03407.16 PIK34368.1 - 2.1e-23 83.4 0.0 3.2e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Sulfotransfer_2 PF03567.14 PIK34369.1 - 8.7e-06 25.8 0.1 1.9e-05 24.7 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase family CPW_WPC PF09717.10 PIK34369.1 - 0.073 14.1 2.3 0.76 10.8 1.0 2.9 3 1 0 3 3 3 0 Plasmodium falciparum domain of unknown function (CPW_WPC) Lipase_GDSL PF00657.22 PIK34370.1 - 5.3e-11 42.9 0.0 7.9e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3668 PF12416.8 PIK34370.1 - 0.0016 18.3 0.0 0.0059 16.4 0.0 1.8 2 0 0 2 2 2 1 Cep120 protein DUF4035 PF13227.6 PIK34370.1 - 0.017 14.8 0.0 0.043 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4035) HEAT PF02985.22 PIK34371.1 - 4.4e-16 57.6 0.3 0.00027 20.9 0.0 5.0 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.6 PIK34371.1 - 1.6e-12 47.7 0.2 0.042 14.4 0.0 5.3 3 3 3 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 PIK34371.1 - 1.3e-07 31.9 0.0 0.017 15.5 0.0 4.2 2 1 3 5 5 5 3 HEAT repeats Cnd1 PF12717.7 PIK34371.1 - 1.9e-06 28.0 0.1 1.6 8.8 0.0 3.8 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 PIK34371.1 - 0.0001 21.6 0.0 0.0016 17.6 0.0 2.4 1 1 1 2 2 2 1 Interferon-related developmental regulator (IFRD) Arm PF00514.23 PIK34371.1 - 0.0013 18.7 0.8 0.052 13.6 0.1 3.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 PIK34371.1 - 0.0024 18.4 0.0 15 6.3 0.0 4.0 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Glyco_tran_WecB PF03808.13 PIK34373.1 - 0.093 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family zf-C2H2 PF00096.26 PIK34374.1 - 0.0054 17.1 6.9 0.17 12.4 1.0 3.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-ACC PF17848.1 PIK34374.1 - 0.16 12.1 3.7 0.2 11.8 0.3 2.8 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PHD PF00628.29 PIK34375.1 - 3.1e-06 27.0 6.9 6.2e-06 26.0 6.9 1.5 1 0 0 1 1 1 1 PHD-finger SprT-like PF10263.9 PIK34375.1 - 0.00014 21.7 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 SprT-like family Peptidase_C48 PF02902.19 PIK34375.1 - 0.023 14.5 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain CDC24_OB3 PF17244.2 PIK34375.1 - 0.43 10.3 3.3 2.4 7.8 3.5 2.0 1 1 0 1 1 1 0 Cell division control protein 24, OB domain 3 C1_1 PF00130.22 PIK34375.1 - 0.61 10.0 6.1 0.32 10.9 1.2 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ANAPC4_WD40 PF12894.7 PIK34377.1 - 1.4e-13 51.0 0.0 3.5e-06 27.2 0.0 4.7 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK34377.1 - 1.4e-08 35.2 9.0 0.16 12.9 1.2 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK34377.1 - 0.00069 18.7 0.1 0.035 13.1 0.0 2.8 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK34377.1 - 0.017 14.4 0.0 9.9 5.4 0.0 3.0 3 0 0 3 3 3 0 WD40-like domain Cytochrom_D1 PF02239.16 PIK34377.1 - 0.038 12.5 0.0 0.83 8.1 0.0 2.1 1 1 1 2 2 2 0 Cytochrome D1 heme domain Frtz PF11768.8 PIK34377.1 - 0.086 11.1 0.0 0.15 10.4 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz HELP PF03451.14 PIK34378.1 - 6.4e-33 112.4 0.1 4.1e-18 65.0 0.0 2.4 2 0 0 2 2 2 2 HELP motif WD40 PF00400.32 PIK34378.1 - 1.1e-25 89.4 31.8 0.00021 22.0 0.1 12.7 12 1 1 13 13 13 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK34378.1 - 2e-09 37.6 3.8 0.0034 17.7 0.0 6.1 3 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 PIK34378.1 - 0.0085 14.7 0.2 4.8 5.6 0.1 2.8 2 1 0 2 2 2 2 Cytochrome D1 heme domain DUF4845 PF16137.5 PIK34378.1 - 0.076 13.9 1.1 0.23 12.3 1.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4845) Nucleoporin_N PF08801.11 PIK34378.1 - 0.089 11.5 0.0 5 5.7 0.0 2.2 2 0 0 2 2 2 0 Nup133 N terminal like EpoR_lig-bind PF09067.10 PIK34379.1 - 2e-07 31.1 0.0 3.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.10 PIK34379.1 - 1.9e-06 28.2 0.4 1.9e-06 28.2 0.4 1.6 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.21 PIK34379.1 - 3.6e-06 27.2 0.7 0.0017 18.7 0.1 2.4 2 1 0 2 2 2 2 Fibronectin type III domain Tissue_fac PF01108.17 PIK34379.1 - 0.0075 16.1 2.5 0.017 15.0 0.1 2.2 2 0 0 2 2 2 1 Tissue factor fn3 PF00041.21 PIK34380.1 - 2.4e-09 37.4 0.1 0.0011 19.3 0.1 2.1 2 0 0 2 2 2 2 Fibronectin type III domain fn3 PF00041.21 PIK34382.1 - 3.2e-20 72.3 4.9 5e-09 36.4 0.5 3.2 3 0 0 3 3 3 3 Fibronectin type III domain SusE PF14292.6 PIK34382.1 - 6.1e-05 23.2 0.5 0.19 12.0 0.0 2.8 2 1 1 3 3 3 2 SusE outer membrane protein Pur_ac_phosph_N PF16656.5 PIK34382.1 - 0.008 16.7 3.5 2.3 8.9 0.1 3.2 2 1 1 3 3 3 2 Purple acid Phosphatase, N-terminal domain TRAPP PF04051.16 PIK34383.1 - 9.2e-18 64.4 0.0 1e-17 64.2 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component NIDO PF06119.14 PIK34385.1 - 5.9e-12 46.4 0.4 1.9e-11 44.7 0.1 1.9 2 1 0 2 2 2 1 Nidogen-like DUF4421 PF14391.6 PIK34385.1 - 0.031 13.7 2.8 0.044 13.2 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4421) EGF_CA PF07645.15 PIK34386.1 - 2.3e-39 133.3 86.6 3.6e-09 36.7 10.1 7.0 6 0 0 6 6 6 5 Calcium-binding EGF domain EGF_3 PF12947.7 PIK34386.1 - 4.5e-26 90.8 96.4 8.5e-12 45.1 6.6 8.5 7 1 1 8 8 8 5 EGF domain cEGF PF12662.7 PIK34386.1 - 3.5e-22 78.0 73.8 1.2e-06 28.4 5.1 8.5 9 0 0 9 9 9 5 Complement Clr-like EGF-like VWD PF00094.25 PIK34386.1 - 6.2e-11 42.8 0.4 3e-10 40.6 0.4 2.2 1 1 0 1 1 1 1 von Willebrand factor type D domain hEGF PF12661.7 PIK34386.1 - 2.5e-09 37.4 78.7 0.00035 21.1 4.9 10.0 8 2 0 8 8 8 6 Human growth factor-like EGF AMOP PF03782.17 PIK34386.1 - 4.4e-09 36.6 6.0 1.4e-08 34.9 6.0 2.0 1 0 0 1 1 1 1 AMOP domain EGF PF00008.27 PIK34386.1 - 4.7e-08 33.2 89.0 0.0062 16.8 6.8 8.6 8 0 0 8 8 8 6 EGF-like domain FXa_inhibition PF14670.6 PIK34386.1 - 9.1e-07 29.1 100.3 0.00017 21.8 12.2 8.5 7 2 2 9 9 9 5 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK34386.1 - 0.011 16.1 0.0 0.011 16.1 0.0 8.3 8 1 0 8 8 8 0 EGF-like domain EGF_CA PF07645.15 PIK34387.1 - 2.6e-81 267.6 280.8 5.2e-09 36.2 12.4 16.8 16 1 1 17 17 17 14 Calcium-binding EGF domain EGF_3 PF12947.7 PIK34387.1 - 3.6e-61 203.1 227.9 5.6e-09 36.1 13.6 16.3 14 1 1 15 15 15 13 EGF domain cEGF PF12662.7 PIK34387.1 - 4.1e-61 202.5 156.9 4.8e-07 29.6 7.4 16.2 15 0 0 15 15 15 12 Complement Clr-like EGF-like EGF PF00008.27 PIK34387.1 - 1.1e-36 124.7 225.3 0.00013 22.2 9.4 19.7 17 3 1 18 18 18 13 EGF-like domain FXa_inhibition PF14670.6 PIK34387.1 - 2.3e-21 75.8 216.6 0.00012 22.3 5.9 16.4 9 5 6 15 15 15 11 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK34387.1 - 2.5e-18 66.0 193.8 0.00059 20.4 2.9 21.1 19 2 1 20 20 20 12 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK34387.1 - 7.6e-12 45.1 187.4 0.00022 21.2 5.7 14.8 15 0 0 15 15 15 10 MSP1 EGF domain 1 SEA PF01390.20 PIK34387.1 - 0.0004 20.4 0.9 1.1 9.3 0.1 2.4 2 0 0 2 2 2 2 SEA domain EphA2_TM PF14575.6 PIK34387.1 - 0.11 13.4 0.0 0.25 12.3 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LapA_dom PF06305.11 PIK34387.1 - 0.23 11.3 0.0 0.45 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Acetyltransf_4 PF13420.7 PIK34389.1 - 0.045 13.9 0.0 0.066 13.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PSI_PSAK PF01241.18 PIK34389.1 - 0.053 13.5 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Photosystem I psaG / psaK SBF PF01758.16 PIK34390.1 - 2.6e-21 76.2 2.5 7e-21 74.8 2.5 1.7 1 0 0 1 1 1 1 Sodium Bile acid symporter family DUF3925 PF13063.6 PIK34390.1 - 0.14 12.4 0.6 0.14 12.4 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3925) RabGAP-TBC PF00566.18 PIK34391.1 - 1.9e-50 171.5 0.2 1.9e-50 171.5 0.2 1.7 2 1 0 2 2 2 1 Rab-GTPase-TBC domain CortBP2 PF09727.9 PIK34392.1 - 3.9e-23 82.4 4.7 5.1e-23 82.0 4.7 1.1 1 0 0 1 1 1 1 Cortactin-binding protein-2 Cupin_4 PF08007.12 PIK34392.1 - 0.047 13.1 1.9 0.096 12.1 1.1 1.7 2 0 0 2 2 2 0 Cupin superfamily protein Bap31_Bap29_C PF18035.1 PIK34392.1 - 0.051 13.6 2.3 0.56 10.2 2.0 2.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Cob_adeno_trans PF01923.18 PIK34392.1 - 0.087 13.0 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase BCDHK_Adom3 PF10436.9 PIK34392.1 - 0.16 11.8 2.7 0.59 9.9 2.4 1.9 1 1 1 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DNA_pol_A_exo1 PF01612.20 PIK34393.1 - 8.9e-22 77.6 0.1 1.3e-21 77.1 0.1 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Arm-DNA-bind_3 PF13356.6 PIK34393.1 - 0.16 12.3 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Arm DNA-binding domain Toxin_trans PF07952.12 PIK34394.1 - 1.2 8.1 6.4 0.31 10.1 2.2 1.9 1 1 0 2 2 2 0 Clostridium neurotoxin, Translocation domain DED PF01335.21 PIK34395.1 - 4.5e-15 55.7 2.6 4.5e-15 55.7 2.6 2.2 2 0 0 2 2 2 1 Death effector domain NB-ARC PF00931.22 PIK34395.1 - 2.2e-07 30.3 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_22 PF13401.6 PIK34395.1 - 3.1e-05 24.3 0.3 0.00019 21.7 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK34395.1 - 0.00014 22.3 0.0 0.0014 19.1 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 PIK34395.1 - 0.0071 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 PIK34395.1 - 0.014 14.7 0.0 0.023 13.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 PIK34395.1 - 0.022 15.2 0.0 0.053 13.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK34395.1 - 0.026 15.1 0.7 0.11 13.0 0.0 2.7 3 1 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 PIK34395.1 - 0.03 14.3 0.3 0.27 11.1 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Ala_racemase_N PF01168.20 PIK34395.1 - 0.095 12.3 0.0 0.26 10.9 0.0 1.7 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain AAA_19 PF13245.6 PIK34395.1 - 0.16 12.3 0.0 0.39 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain FtsQ PF03799.15 PIK34396.1 - 0.017 15.9 0.1 0.053 14.3 0.1 1.8 1 0 0 1 1 1 0 Cell division protein FtsQ Sulfotransfer_2 PF03567.14 PIK34397.1 - 5.9e-09 36.2 0.6 3.8e-08 33.6 0.6 2.2 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK34397.1 - 0.061 12.8 0.1 0.17 11.4 0.1 1.9 1 1 1 2 2 2 0 Sulfotransferase domain CheR_N PF03705.15 PIK34397.1 - 0.08 12.7 0.0 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain zf-RVT PF13966.6 PIK34398.1 - 0.00032 21.3 2.3 0.00032 21.3 2.3 1.9 2 1 0 2 2 2 1 zinc-binding in reverse transcriptase NPL4 PF05021.15 PIK34399.1 - 6.3e-69 232.7 4.1 1e-51 176.2 0.2 3.1 1 1 2 3 3 3 3 NPL4 family zf-NPL4 PF05020.15 PIK34399.1 - 1.5e-60 203.5 0.6 3.5e-60 202.4 0.6 1.6 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region zf-RanBP PF00641.18 PIK34399.1 - 2e-07 30.2 1.0 2e-07 30.2 1.0 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others UN_NPL4 PF11543.8 PIK34399.1 - 3.3e-07 30.7 0.0 6.7e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 RecR PF02132.15 PIK34399.1 - 0.13 11.8 2.6 0.4 10.3 2.6 1.9 1 0 0 1 1 1 0 RecR protein Glyco_hydro_85 PF03644.13 PIK34400.1 - 1.2e-60 205.6 0.3 1.7e-60 205.0 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Kinesin PF00225.23 PIK34401.1 - 3.6e-26 91.9 0.0 6.2e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 PIK34401.1 - 2.7e-12 47.2 7.4 8.6e-06 26.0 0.4 2.3 1 1 1 2 2 2 2 Kinesin-associated Beta_protein PF14350.6 PIK34401.1 - 0.057 12.8 0.0 0.069 12.6 0.0 1.1 1 0 0 1 1 1 0 Beta protein KIF1B PF12423.8 PIK34402.1 - 4.6e-16 59.0 0.4 1.7e-15 57.2 0.4 2.1 1 0 0 1 1 1 1 Kinesin protein 1B DUF3694 PF12473.8 PIK34402.1 - 1.4e-15 58.3 0.1 2.2e-06 28.4 0.1 2.6 2 0 0 2 2 2 2 Kinesin protein FHA PF00498.26 PIK34402.1 - 0.001 19.4 0.0 0.003 17.9 0.0 1.8 1 0 0 1 1 1 1 FHA domain DUF3585 PF12130.8 PIK34402.1 - 0.027 14.6 1.4 0.027 14.6 1.4 2.3 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Kinesin_assoc PF16183.5 PIK34402.1 - 0.033 14.3 0.0 0.033 14.3 0.0 2.6 2 0 0 2 2 2 0 Kinesin-associated Rapsyn_N PF10579.9 PIK34402.1 - 0.11 12.6 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region TPX2 PF06886.11 PIK34402.1 - 0.48 10.7 10.4 5.7 7.3 0.2 2.8 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) KfrA_N PF11740.8 PIK34402.1 - 4 8.2 8.0 0.44 11.2 3.4 1.8 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term PIF1 PF05970.14 PIK34404.1 - 1.5e-20 73.7 0.4 4.2e-19 68.9 0.0 2.0 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 PIK34404.1 - 9.3e-14 51.6 0.0 1.4e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK34404.1 - 6.5e-07 29.8 0.0 2.5e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain PDZ PF00595.24 PIK34405.1 - 1.6e-06 28.3 0.1 2.7e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK34405.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 PDZ domain MutS_V PF00488.21 PIK34406.1 - 1e-52 178.9 0.6 1.5e-52 178.4 0.2 1.5 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 PIK34406.1 - 0.00017 21.9 0.6 0.00033 20.9 0.3 1.6 2 0 0 2 2 2 1 MutS domain III AAA_29 PF13555.6 PIK34406.1 - 0.061 13.1 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4828 PF16110.5 PIK34406.1 - 0.08 13.4 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4828) AAA_14 PF13173.6 PIK34406.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK34406.1 - 0.18 11.7 0.1 3.6 7.4 0.1 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea SAC3_GANP PF03399.16 PIK34407.1 - 1.8e-16 60.4 0.9 3.7e-16 59.4 0.0 1.7 2 0 0 2 2 2 1 SAC3/GANP family RRM_1 PF00076.22 PIK34407.1 - 0.0004 20.1 0.0 0.0009 19.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK34407.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nucleoporin_FG PF13634.6 PIK34407.1 - 0.068 14.0 10.5 2.1 9.2 5.4 3.2 1 1 1 2 2 2 0 Nucleoporin FG repeat region P5CR_dimer PF14748.6 PIK34408.1 - 8.7e-25 87.0 0.0 1e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation HMGL-like PF00682.19 PIK34409.1 - 8.3e-40 137.0 0.4 1.8e-21 76.9 0.1 2.1 1 1 1 2 2 2 2 HMGL-like E3_UbLigase_EDD PF11547.8 PIK34409.1 - 0.078 12.7 0.3 0.19 11.4 0.1 1.8 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD Orn_Arg_deC_N PF02784.16 PIK34410.1 - 5.1e-60 202.9 0.0 6.6e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 PIK34410.1 - 2.1e-10 40.7 0.0 3e-10 40.2 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Sulfotransfer_1 PF00685.27 PIK34411.1 - 7.9e-06 25.5 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Pkinase PF00069.25 PIK34412.1 - 4.7e-71 239.2 0.0 8.6e-71 238.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34412.1 - 2.9e-34 118.5 0.1 5.6e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK34412.1 - 3.5e-05 23.3 0.1 6.8e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK34412.1 - 0.026 13.9 0.0 0.052 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Acyl-CoA_dh_1 PF00441.24 PIK34413.1 - 6.4e-45 153.0 3.1 1e-44 152.4 3.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK34413.1 - 5e-31 107.7 0.0 1.5e-30 106.1 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK34413.1 - 2.1e-25 89.5 1.7 4.2e-25 88.6 1.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK34413.1 - 1.1e-24 86.4 0.0 2.3e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain WD40 PF00400.32 PIK34414.1 - 1.9e-14 53.8 10.1 5.6e-07 30.2 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK34414.1 - 0.00056 20.2 0.1 11 6.4 0.0 3.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain CBM26 PF16738.5 PIK34414.1 - 0.77 10.1 5.6 20 5.5 0.3 3.5 4 0 0 4 4 4 0 Starch-binding module 26 SpoU_methylase PF00588.19 PIK34415.1 - 9.1e-15 55.1 0.0 1.3e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 PIK34415.1 - 2.6e-05 24.4 0.0 0.00034 20.8 0.0 2.4 2 1 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding DUF4536 PF15055.6 PIK34416.1 - 0.019 15.2 1.0 0.14 12.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) zf-C3HC4_3 PF13920.6 PIK34417.1 - 3.6e-11 42.7 5.2 5.6e-11 42.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK34417.1 - 3.5e-10 40.0 9.4 5.9e-10 39.3 9.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK34417.1 - 4.4e-10 39.4 6.9 9.4e-10 38.4 6.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK34417.1 - 2e-09 37.1 9.4 3.4e-09 36.4 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK34417.1 - 6.1e-09 35.6 8.4 1e-08 34.9 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK34417.1 - 5.5e-08 33.0 5.0 1e-07 32.1 5.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 PIK34417.1 - 1.3e-07 31.5 5.9 2.5e-07 30.5 5.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK34417.1 - 8.9e-07 28.7 8.2 4.8e-06 26.3 8.4 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK34417.1 - 1.9e-06 27.9 9.2 4e-06 26.9 9.2 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 PIK34417.1 - 0.001 19.1 1.6 0.002 18.2 1.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 PIK34417.1 - 0.0039 17.0 3.2 0.0042 16.9 1.7 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 PIK34417.1 - 0.031 14.1 4.2 0.087 12.7 4.3 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 PIK34417.1 - 0.034 13.8 4.2 0.063 12.9 4.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 PIK34417.1 - 0.091 12.6 7.0 1.3 8.8 4.4 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 PIK34417.1 - 0.15 12.1 5.2 0.25 11.4 5.2 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-RING_10 PF16685.5 PIK34417.1 - 0.2 11.8 5.4 0.54 10.4 5.4 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 UBZ_FAAP20 PF15750.5 PIK34417.1 - 0.42 10.6 3.7 15 5.6 0.4 2.7 3 0 0 3 3 2 0 Ubiquitin-binding zinc-finger TMEM251 PF15190.6 PIK34417.1 - 0.61 10.1 5.1 0.64 10.0 0.6 2.4 2 0 0 2 2 2 0 Transmembrane protein 251 zf-C3HC4_5 PF17121.5 PIK34417.1 - 1.3 8.9 9.2 7.8 6.5 9.2 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIB PF13453.6 PIK34417.1 - 6.2 6.2 10.7 0.51 9.7 4.5 2.4 1 1 1 2 2 2 0 Transcription factor zinc-finger RVT_1 PF00078.27 PIK34418.1 - 0.001 18.7 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK34420.1 - 3.3e-07 30.4 0.0 6.7e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Yae1_N PF09811.9 PIK34420.1 - 0.00084 19.0 0.3 0.014 15.1 0.1 2.7 2 1 0 2 2 2 1 Essential protein Yae1, N terminal AAA_25 PF13481.6 PIK34420.1 - 0.13 11.9 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK34421.1 - 1.4e-13 51.1 0.1 1.5e-12 47.7 0.0 2.5 3 0 0 3 3 3 1 NACHT domain V-set PF07686.17 PIK34421.1 - 1e-07 32.1 1.1 0.0096 16.1 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK34421.1 - 0.0042 17.4 2.4 11 6.5 0.1 4.0 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK34421.1 - 0.0052 16.9 7.4 0.81 9.9 0.0 4.8 4 2 1 5 5 5 1 Immunoglobulin domain AAA_22 PF13401.6 PIK34421.1 - 0.02 15.2 0.0 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 PIK34421.1 - 0.025 15.0 0.0 0.073 13.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 PIK34421.1 - 0.033 13.8 0.0 0.24 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain CD34_antigen PF06365.12 PIK34421.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF1467 PF07330.12 PIK34421.1 - 0.16 11.9 0.5 0.34 10.9 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) UPF0640 PF15114.6 PIK34421.1 - 0.19 11.5 0.8 3.6 7.5 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0640 C2-set_2 PF08205.12 PIK34421.1 - 0.93 9.6 2.7 2.1 8.5 0.1 2.9 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain DUF4044 PF13253.6 PIK34421.1 - 1.6 8.3 5.1 3.1 7.4 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Dpy19 PF10034.9 PIK34422.1 - 8.7e-83 278.6 31.1 4.2e-74 249.9 22.6 2.0 1 1 1 2 2 2 2 Q-cell neuroblast polarisation Methyltransf_23 PF13489.6 PIK34423.1 - 1.2e-16 60.9 0.0 2.1e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK34423.1 - 2.6e-14 53.7 0.0 1.1e-13 51.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK34423.1 - 2.6e-13 50.5 0.0 7e-13 49.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34423.1 - 1.9e-10 41.2 0.0 4.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34423.1 - 2.2e-08 34.0 0.0 5.3e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Presenilin PF01080.17 PIK34423.1 - 1.6 7.4 3.4 2.1 7.0 3.4 1.1 1 0 0 1 1 1 0 Presenilin YL1_C PF08265.11 PIK34424.1 - 4.6e-09 35.9 0.0 8.7e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain HOOK PF05622.12 PIK34425.1 - 1.9e-13 49.5 0.3 1.9e-13 49.5 0.3 1.0 1 0 0 1 1 1 1 HOOK protein CTP_synth_N PF06418.14 PIK34425.1 - 0.095 12.0 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 CTP synthase N-terminus DDE_1 PF03184.19 PIK34426.1 - 4.1e-21 75.4 0.0 5.5e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_ABP1_N PF18107.1 PIK34426.1 - 0.46 10.2 2.5 18 5.1 1.1 2.2 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain Kazal_2 PF07648.15 PIK34427.1 - 0.00028 20.9 1.6 0.00078 19.5 1.6 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK34427.1 - 0.029 14.4 0.7 0.06 13.4 0.7 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF4045 PF13254.6 PIK34427.1 - 0.24 11.0 14.3 0.29 10.7 14.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) HNF-1_N PF04814.13 PIK34427.1 - 3.3 8.3 13.6 4.7 7.8 13.6 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus zf-C2HC_2 PF13913.6 PIK34429.1 - 3e-05 23.8 1.1 4.8e-05 23.2 1.1 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-CHCC PF10276.9 PIK34429.1 - 0.02 14.9 0.5 0.034 14.2 0.5 1.3 1 0 0 1 1 1 0 Zinc-finger domain FAM76 PF16046.5 PIK34429.1 - 0.038 13.3 1.0 0.062 12.6 1.0 1.3 1 0 0 1 1 1 0 FAM76 protein Nairovirus_M PF07948.11 PIK34429.1 - 0.096 10.9 0.5 0.14 10.4 0.5 1.1 1 0 0 1 1 1 0 Nairovirus M polyprotein-like YacG PF03884.14 PIK34429.1 - 0.099 12.4 1.1 0.21 11.4 1.1 1.5 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG Peptidase_A17 PF05380.13 PIK34430.1 - 1e-40 139.4 0.7 1.8e-40 138.6 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK34431.1 - 0.00011 21.8 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VraX PF17412.2 PIK34431.1 - 0.68 9.6 2.5 3 7.6 0.0 2.5 2 1 1 3 3 3 0 Family of unknown function DUF1759 PF03564.15 PIK34432.1 - 9.6e-08 32.1 0.1 1.6e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK34432.1 - 0.12 12.9 2.5 0.25 11.9 0.1 2.5 3 0 0 3 3 3 0 Tis11B like protein, N terminus NUDE_C PF04880.13 PIK34432.1 - 0.73 10.3 8.1 0.43 11.1 5.2 2.0 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Thioredoxin PF00085.20 PIK34433.1 - 1.5e-39 134.2 0.0 2.1e-17 63.0 0.0 4.3 4 0 0 4 4 4 2 Thioredoxin DnaJ PF00226.31 PIK34433.1 - 4.2e-23 81.2 2.9 9.3e-23 80.1 2.9 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_8 PF13905.6 PIK34433.1 - 1.4e-05 25.4 0.3 0.88 9.9 0.0 4.1 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_3 PF13192.6 PIK34433.1 - 0.00027 20.9 0.0 0.68 10.0 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin domain TraF PF13728.6 PIK34433.1 - 0.0017 18.3 0.1 0.15 11.8 0.0 2.5 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 PIK34433.1 - 0.0019 18.6 1.3 6.5 7.3 0.2 3.9 2 2 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 PIK34433.1 - 0.016 14.5 0.5 0.33 10.2 0.2 2.4 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 PIK34433.1 - 0.023 14.4 0.1 0.092 12.5 0.1 2.0 1 0 0 1 1 1 0 Thioredoxin Thioredoxin PF00085.20 PIK34434.1 - 1.2e-28 99.1 0.1 8.2e-22 77.1 0.0 2.8 2 1 1 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 PIK34434.1 - 0.01 15.2 0.0 0.012 15.0 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 PIK34434.1 - 0.031 14.6 0.1 0.12 12.7 0.0 2.1 3 0 0 3 3 3 0 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK34434.1 - 0.1 13.0 0.0 0.34 11.4 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Trypsin PF00089.26 PIK34436.1 - 8.5e-24 84.6 0.3 1.8e-12 47.6 0.4 2.2 2 0 0 2 2 2 2 Trypsin Ldl_recept_a PF00057.18 PIK34436.1 - 0.069 13.4 0.6 0.069 13.4 0.6 1.6 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK34437.1 - 4.5e-20 72.0 0.4 1.3e-19 70.5 0.0 2.0 2 0 0 2 2 2 1 CUB domain UT PF03253.14 PIK34437.1 - 0.076 12.1 0.0 0.16 11.1 0.0 1.4 2 0 0 2 2 2 0 Urea transporter LapA_dom PF06305.11 PIK34437.1 - 0.22 11.4 0.1 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FtsJ PF01728.19 PIK34438.1 - 2.7e-53 180.7 0.0 3.3e-53 180.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase p450 PF00067.22 PIK34439.1 - 6.5e-06 25.2 0.0 8e-06 24.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK34440.1 - 7.8e-47 160.1 0.0 9.1e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CIAPIN1 PF05093.13 PIK34441.1 - 0.012 16.1 0.1 0.031 14.8 0.1 1.7 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltranf_PUA PF13636.6 PIK34441.1 - 0.068 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 RNA-binding PUA-like domain of methyltransferase RsmF DM PF00751.18 PIK34441.1 - 9.8 6.2 8.9 0.59 10.1 2.3 2.2 2 0 0 2 2 2 0 DM DNA binding domain DUF1980 PF09323.10 PIK34442.1 - 0.036 14.0 0.2 0.14 12.1 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) DUF5480 PF17576.2 PIK34442.1 - 0.17 11.9 1.6 3.4 7.7 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5480) MarC PF01914.17 PIK34443.1 - 0.22 10.9 0.3 0.43 10.0 0.1 1.4 2 0 0 2 2 2 0 MarC family integral membrane protein PET PF06297.14 PIK34445.1 - 3.8e-36 123.3 0.3 7.6e-36 122.3 0.3 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 PIK34445.1 - 9.5e-25 86.6 52.1 1.4e-10 41.2 15.2 4.2 4 0 0 4 4 4 3 LIM domain CBFD_NFYB_HMF PF00808.23 PIK34446.1 - 1.1e-28 99.3 0.3 1.8e-28 98.6 0.3 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK34446.1 - 7.2e-07 29.6 0.1 1.1e-06 29.0 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK34446.1 - 0.00087 19.4 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 PIK34446.1 - 0.0011 19.0 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit PAN_3 PF08277.12 PIK34446.1 - 0.044 13.6 0.3 0.11 12.3 0.3 1.6 1 0 0 1 1 1 0 PAN-like domain CENP-X PF09415.10 PIK34446.1 - 0.054 13.8 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 CENP-S associating Centromere protein X OATP PF03137.20 PIK34447.1 - 3.7e-117 391.9 15.7 4.7e-117 391.6 15.7 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK34447.1 - 2.2e-17 63.0 22.9 2.2e-17 63.0 22.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK34447.1 - 6.9e-06 26.1 11.3 1.6e-05 25.0 11.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK34447.1 - 0.019 15.0 5.1 0.043 13.8 5.1 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Sulfate_transp PF00916.20 PIK34448.1 - 0.095 11.4 0.4 0.11 11.2 0.4 1.1 1 0 0 1 1 1 0 Sulfate permease family LRR_8 PF13855.6 PIK34449.1 - 3.3e-15 55.6 0.5 1.3e-13 50.5 0.1 1.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK34449.1 - 1.7e-07 31.4 0.6 0.0011 19.3 0.3 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK34449.1 - 4.8e-05 23.4 0.2 0.44 11.3 0.4 3.7 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK34449.1 - 0.00021 21.2 0.1 0.00031 20.7 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK34449.1 - 0.0013 18.6 1.5 2.5 8.4 0.2 3.0 3 0 0 3 3 3 2 Leucine Rich repeat LRR_9 PF14580.6 PIK34449.1 - 0.072 12.6 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat MULE PF10551.9 PIK34451.1 - 0.01 16.2 0.1 0.022 15.1 0.1 1.5 1 0 0 1 1 1 0 MULE transposase domain Arabinose_Iso_C PF11762.8 PIK34451.1 - 0.079 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain DUF5311 PF17238.2 PIK34451.1 - 0.087 12.7 0.4 3.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5311) THAP PF05485.12 PIK34452.1 - 2.3e-10 41.3 0.8 4.2e-10 40.4 0.8 1.4 1 0 0 1 1 1 1 THAP domain SAM_2 PF07647.17 PIK34452.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) NACHT PF05729.12 PIK34453.1 - 5.8e-11 42.6 0.0 1.4e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK34453.1 - 0.02 15.1 0.0 0.073 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_AID PF00309.20 PIK34453.1 - 0.042 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) DUF2075 PF09848.9 PIK34453.1 - 0.1 11.8 0.7 0.56 9.4 0.0 2.3 2 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 PIK34453.1 - 0.27 11.6 1.7 3.2 8.2 0.7 3.0 2 1 0 2 2 2 0 RNA helicase Death PF00531.22 PIK34454.1 - 8.7e-15 54.7 1.1 9.6e-15 54.5 1.1 1.1 1 0 0 1 1 1 1 Death domain HTH_3 PF01381.22 PIK34454.1 - 0.014 15.4 0.0 0.16 12.1 0.0 2.2 1 1 1 2 2 2 0 Helix-turn-helix YdaS_antitoxin PF15943.5 PIK34454.1 - 0.077 12.9 0.0 3.9 7.4 0.0 2.2 1 1 1 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Death PF00531.22 PIK34455.1 - 1.2e-10 41.4 0.1 1.5e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 Death domain Dehydratase_LU PF02286.15 PIK34455.1 - 0.039 12.6 0.3 0.043 12.4 0.3 1.0 1 0 0 1 1 1 0 Dehydratase large subunit BRICHOS PF04089.14 PIK34456.1 - 3.3e-13 49.7 0.1 5.1e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 BRICHOS domain MFS_1 PF07690.16 PIK34457.1 - 7.9e-10 38.2 17.4 0.00031 19.8 14.5 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily SLC3A2_N PF16028.5 PIK34457.1 - 0.35 10.4 1.6 14 5.3 0.1 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus Ig_3 PF13927.6 PIK34458.1 - 6.3e-08 33.1 0.1 0.0034 17.9 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK34458.1 - 0.014 15.5 0.0 0.044 13.9 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 PIK34458.1 - 0.055 13.6 0.6 0.53 10.5 0.1 2.5 2 1 0 2 2 2 0 Immunoglobulin V-set domain Trypan_glycop_C PF10659.9 PIK34459.1 - 0.00067 20.0 2.5 4.1 7.8 1.4 4.2 1 1 1 2 2 2 2 Trypanosome variant surface glycoprotein C-terminal domain Lipase PF00151.19 PIK34459.1 - 0.014 14.7 5.2 7.2 5.8 0.2 3.6 1 1 3 4 4 4 0 Lipase DUF1864 PF08933.11 PIK34459.1 - 0.071 11.9 0.5 30 3.2 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF1864) PADR1 PF08063.12 PIK34459.1 - 0.18 11.6 10.3 75 3.2 0.0 5.8 7 0 0 7 7 7 0 PADR1 (NUC008) domain DUF3332 PF11810.8 PIK34459.1 - 0.64 9.6 7.7 3.7 7.2 1.6 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF3332) ubiquitin PF00240.23 PIK34460.1 - 2.1e-52 174.8 3.2 3.5e-26 90.8 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK34460.1 - 3.9e-28 97.1 5.5 2.5e-14 52.9 1.1 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34460.1 - 8.5e-11 42.2 0.7 0.00014 22.3 0.0 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK34460.1 - 6.5e-08 32.4 0.2 0.0048 16.8 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 PIK34460.1 - 2.1e-06 28.2 0.0 0.012 16.1 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34460.1 - 3e-06 27.3 0.1 0.0035 17.4 0.0 2.7 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 PIK34460.1 - 0.0013 19.1 0.6 0.65 10.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-like domain USP7_C2 PF14533.6 PIK34460.1 - 0.0045 16.7 0.6 0.16 11.7 0.1 2.2 1 1 1 2 2 2 1 Ubiquitin-specific protease C-terminal UN_NPL4 PF11543.8 PIK34460.1 - 0.043 14.3 0.1 11 6.6 0.0 2.4 2 1 0 2 2 2 0 Nuclear pore localisation protein NPL4 FERM_N PF09379.10 PIK34460.1 - 0.048 13.6 0.5 2.1 8.3 0.1 3.2 3 1 0 3 3 3 0 FERM N-terminal domain Ubiquitin_4 PF18036.1 PIK34460.1 - 0.048 13.7 6.2 13 5.9 0.1 3.9 2 2 2 4 4 4 0 Ubiquitin-like domain Polysacc_deac_3 PF15421.6 PIK34460.1 - 0.076 11.5 0.1 1.3 7.5 0.0 2.3 1 1 1 2 2 2 0 Putative polysaccharide deacetylase RRM_1 PF00076.22 PIK34461.1 - 1.9e-06 27.6 0.0 3.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MliC PF09864.9 PIK34461.1 - 0.12 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Peptidase_M13 PF01431.21 PIK34462.1 - 8.6e-66 221.5 0.0 1.6e-65 220.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 PIK34462.1 - 4.7e-61 207.6 0.1 7.5e-61 206.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M13 TnpW PF14202.6 PIK34462.1 - 0.035 13.9 0.1 0.069 13.0 0.1 1.5 1 0 0 1 1 1 0 Transposon-encoded protein TnpW FBA PF04300.13 PIK34463.1 - 9.7e-54 181.7 0.0 1.4e-53 181.2 0.0 1.2 1 0 0 1 1 1 1 F-box associated region F-box PF00646.33 PIK34463.1 - 4.6e-07 29.5 0.7 1.3e-06 28.1 0.7 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK34463.1 - 9.6e-07 28.6 0.1 2.6e-06 27.2 0.1 1.8 1 0 0 1 1 1 1 F-box-like RVT_1 PF00078.27 PIK34464.1 - 5.6e-08 32.6 0.1 1.3e-07 31.4 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK34464.1 - 0.032 14.1 0.2 0.55 10.1 0.0 2.4 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase DUF3087 PF11286.8 PIK34465.1 - 0.012 15.1 0.2 3.1 7.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Abhydrolase_1 PF00561.20 PIK34466.1 - 2.5e-08 33.9 0.0 0.00018 21.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK34466.1 - 5.3e-05 22.6 0.0 0.00027 20.3 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF4940 PF16298.5 PIK34466.1 - 0.12 12.1 0.4 0.18 11.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4940) Peptidase_C14 PF00656.22 PIK34467.1 - 6.6e-39 134.3 0.0 1.1e-38 133.6 0.0 1.4 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 PIK34467.1 - 1.2e-16 60.8 7.4 1.7e-08 34.6 0.0 3.4 3 1 0 3 3 3 2 Death effector domain ALC PF17527.2 PIK34467.1 - 0.066 12.9 2.7 0.68 9.6 0.1 2.9 3 0 0 3 3 3 0 Phage ALC protein rve_2 PF13333.6 PIK34467.1 - 0.19 11.9 0.5 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain Elongin_A PF06881.11 PIK34467.1 - 0.51 10.9 5.2 7.6 7.1 0.3 3.2 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pkinase_Tyr PF07714.17 PIK34468.1 - 1.5e-14 53.9 0.0 5e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK34468.1 - 3.3e-07 30.0 0.0 4.8e-06 26.1 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain CD52 PF15116.6 PIK34468.1 - 1.4 9.0 6.5 3.4 7.8 6.5 1.7 1 0 0 1 1 1 0 CAMPATH-1 antigen Sulfotransfer_1 PF00685.27 PIK34469.1 - 5.9e-21 75.1 0.0 8.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK34469.1 - 3e-12 47.4 0.0 8.7e-07 29.5 0.0 3.3 1 1 1 2 2 2 2 Sulfotransferase family ARS2 PF04959.13 PIK34470.1 - 1.3e-44 152.9 12.2 1.3e-44 152.9 12.2 1.8 1 1 1 2 2 2 1 Arsenite-resistance protein 2 Sulfotransfer_1 PF00685.27 PIK34471.1 - 2.1e-20 73.3 0.0 2.9e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK34471.1 - 2.2e-12 47.8 0.0 1.1e-06 29.2 0.0 3.3 2 1 1 3 3 3 2 Sulfotransferase family ARS2 PF04959.13 PIK34472.1 - 2.7e-40 138.9 0.6 2.7e-40 138.9 0.6 3.1 3 0 0 3 3 3 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 PIK34472.1 - 5.5e-14 52.3 10.3 1.9e-13 50.6 3.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3546) Ribosomal_60s PF00428.19 PIK34472.1 - 1.9 9.1 11.5 0.11 13.1 2.1 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein LRR_8 PF13855.6 PIK34473.1 - 8.5e-20 70.3 20.0 5.2e-13 48.5 8.5 3.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK34473.1 - 2.1e-07 31.1 20.1 3.6e-05 24.0 2.1 4.1 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK34473.1 - 1.3e-06 28.4 0.7 2.8e-06 27.3 0.3 1.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK34473.1 - 0.00029 20.4 8.0 0.00098 18.7 3.5 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LST1 PF05083.13 PIK34473.1 - 0.003 17.8 0.1 0.0097 16.2 0.1 1.9 1 0 0 1 1 1 1 LST-1 protein Baculo_11_kDa PF06143.11 PIK34473.1 - 0.054 13.1 5.4 0.12 12.0 5.4 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family RhodobacterPufX PF11511.8 PIK34473.1 - 0.079 12.6 1.8 1.4 8.6 0.6 2.3 2 0 0 2 2 2 0 Intrinsic membrane protein PufX WBP-1 PF11669.8 PIK34473.1 - 0.087 13.5 0.1 0.31 11.7 0.1 1.9 1 0 0 1 1 1 0 WW domain-binding protein 1 LRR_6 PF13516.6 PIK34473.1 - 0.5 10.5 10.2 0.61 10.3 0.3 3.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 PIK34473.1 - 1.9 9.3 19.8 6.2 7.8 0.3 5.9 4 3 0 4 4 4 0 Leucine Rich Repeat LSR PF05624.14 PIK34473.1 - 2.6 8.1 5.3 6.8 6.8 5.3 1.6 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) C1-set PF07654.15 PIK34474.1 - 0.00056 20.2 2.5 0.0021 18.4 2.5 2.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain V-set PF07686.17 PIK34474.1 - 0.00092 19.4 3.9 0.0016 18.6 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK34474.1 - 0.027 14.6 2.0 0.041 14.1 0.4 2.2 2 1 0 2 2 2 0 Immunoglobulin domain DUF1857 PF08982.11 PIK34474.1 - 0.036 13.9 0.0 0.07 13.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1857) MtrG PF04210.13 PIK34475.1 - 0.029 14.2 0.1 0.067 13.0 0.1 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G DEAD PF00270.29 PIK34476.1 - 0.0064 16.3 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PGAP1 PF07819.13 PIK34477.1 - 2.6e-49 168.0 0.0 3.2e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 PIK34477.1 - 6e-06 26.1 0.0 9.7e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Palm_thioest PF02089.15 PIK34477.1 - 2.4e-05 24.3 0.0 2.7e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 PIK34477.1 - 2.5e-05 25.0 0.0 2.9e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 PIK34477.1 - 0.0004 20.0 0.0 0.0005 19.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 PIK34477.1 - 0.0023 17.8 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 PIK34477.1 - 0.0038 16.5 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Glu_dehyd_C PF16912.5 PIK34477.1 - 0.012 15.2 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus LIDHydrolase PF10230.9 PIK34477.1 - 0.016 14.8 0.4 0.03 13.9 0.5 1.5 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase DUF915 PF06028.11 PIK34477.1 - 0.029 13.7 0.4 0.49 9.7 0.3 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.7 PIK34477.1 - 0.051 13.3 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 PIK34477.1 - 0.052 13.2 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Lipase_2 PF01674.18 PIK34477.1 - 0.069 12.6 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) LCAT PF02450.15 PIK34477.1 - 0.075 12.2 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_3 PF07859.13 PIK34477.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.8 PIK34477.1 - 0.2 11.2 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF3285 PF11688.8 PIK34478.1 - 0.62 10.0 3.1 0.96 9.4 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) DUF2207 PF09972.9 PIK34478.1 - 6.8 5.3 7.3 2 7.1 0.1 2.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) GST_C_3 PF14497.6 PIK34479.1 - 2.4e-19 69.4 0.0 3.9e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK34479.1 - 4.7e-10 39.6 0.0 8e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK34479.1 - 4.5e-05 23.4 0.0 8.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK34479.1 - 0.11 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Nbl1_Borealin_N PF10444.9 PIK34480.1 - 9.1e-18 63.7 0.9 2.6e-17 62.2 0.2 2.0 1 1 1 2 2 2 1 Nbl1 / Borealin N terminal Borealin PF10512.9 PIK34480.1 - 1.8e-10 40.9 0.5 1.8e-10 40.9 0.5 3.4 3 1 1 4 4 4 1 Cell division cycle-associated protein 8 SPX PF03105.19 PIK34480.1 - 0.073 13.0 10.9 0.099 12.5 10.9 1.2 1 0 0 1 1 1 0 SPX domain HEPN_Cthe2314 PF18730.1 PIK34480.1 - 0.091 12.8 0.3 0.16 12.0 0.3 1.4 1 0 0 1 1 1 0 Cthe_2314-like HEPN Mucin PF01456.17 PIK34480.1 - 0.47 10.4 12.6 0.83 9.6 12.6 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4407 PF14362.6 PIK34480.1 - 0.52 9.6 5.2 0.77 9.1 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 60KD_IMP PF02096.20 PIK34482.1 - 6.6e-07 29.4 0.2 9.6e-07 28.9 0.2 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein DUF5326 PF17260.2 PIK34482.1 - 0.081 13.1 0.3 0.13 12.4 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Tmemb_55A PF09788.9 PIK34483.1 - 6.5e-77 257.9 15.6 7.7e-77 257.7 15.6 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zinc_ribbon_12 PF11331.8 PIK34483.1 - 0.035 13.9 1.2 0.035 13.9 1.2 3.7 3 2 0 3 3 3 0 Probable zinc-ribbon domain Sulfatase PF00884.23 PIK34484.1 - 2.6e-35 122.3 0.0 4.1e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK34484.1 - 4.9e-07 30.5 0.0 9.4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase pP_pnuc_1 PF18165.1 PIK34485.1 - 0.034 14.0 4.6 2 8.3 0.6 2.5 2 0 0 2 2 2 0 Predicted pPIWI-associating nuclease DDE_1 PF03184.19 PIK34485.1 - 0.035 13.8 0.0 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 DDE superfamily endonuclease GAT PF03127.14 PIK34485.1 - 0.25 11.6 3.1 6.5 7.1 0.1 2.9 3 0 0 3 3 3 0 GAT domain DUF3349 PF11829.8 PIK34485.1 - 0.26 12.1 2.8 13 6.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) MORN PF02493.20 PIK34486.1 - 5.1e-19 67.0 21.0 5.7e-09 35.4 0.6 5.5 6 0 0 6 6 6 4 MORN repeat Sulfotransfer_2 PF03567.14 PIK34487.1 - 3.6e-13 50.0 0.3 4.6e-13 49.7 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK34487.1 - 0.059 12.8 0.1 0.1 12.0 0.1 1.5 1 1 0 1 1 1 0 Sulfotransferase domain MCM PF00493.23 PIK34488.1 - 8.9e-97 322.6 0.1 1.4e-96 322.0 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 PIK34488.1 - 1.7e-22 79.6 1.5 4.2e-22 78.4 1.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 PIK34488.1 - 6e-16 58.4 0.2 1.6e-15 57.1 0.2 1.7 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 PIK34488.1 - 3.5e-08 33.1 0.0 2.5e-07 30.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK34488.1 - 0.00029 20.8 0.0 0.00081 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK34488.1 - 0.00051 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 PIK34488.1 - 0.0016 19.0 1.1 0.0016 19.0 1.1 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Sigma54_activat PF00158.26 PIK34488.1 - 0.014 15.1 0.0 0.052 13.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Spectrin PF00435.21 PIK34489.1 - 0.19 12.3 0.6 0.31 11.6 0.6 1.3 1 0 0 1 1 1 0 Spectrin repeat tRNA_int_endo PF01974.17 PIK34490.1 - 6.7e-18 64.5 0.0 9.8e-18 64.0 0.0 1.2 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain GPS2_interact PF15784.5 PIK34492.1 - 4.5e-23 81.5 6.9 4.5e-23 81.5 6.9 3.4 2 0 0 2 2 2 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.31 PIK34492.1 - 5.2e-14 52.2 0.2 9.2e-07 29.0 0.1 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK34492.1 - 0.0038 17.4 6.8 0.84 9.9 0.7 3.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain UNC-79 PF14776.6 PIK34492.1 - 0.017 13.9 1.9 0.03 13.1 1.9 1.3 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 UBX PF00789.20 PIK34493.1 - 2.5e-12 46.8 0.0 9.7e-12 44.9 0.0 2.0 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 PIK34493.1 - 3.8e-05 23.8 0.0 8.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 PIK34493.1 - 0.00082 19.1 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Presenilin PF01080.17 PIK34493.1 - 2.5 6.8 4.4 4.2 6.0 4.4 1.3 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 PIK34493.1 - 3.1 8.4 9.2 0.44 11.2 0.4 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TRP_2 PF08344.11 PIK34494.1 - 1.6e-27 95.5 0.7 4.4e-27 94.1 0.7 1.8 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 PIK34494.1 - 4.3e-21 75.3 11.0 9.7e-21 74.1 11.0 1.6 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 PIK34494.1 - 4.4e-09 36.8 0.1 0.0059 17.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK34494.1 - 2.3e-06 27.7 0.0 0.015 15.6 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK34494.1 - 4.3e-06 26.7 0.1 0.18 12.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat PKD_channel PF08016.12 PIK34494.1 - 3.2e-05 22.8 6.3 6.5e-05 21.8 6.3 1.5 1 0 0 1 1 1 1 Polycystin cation channel Ank PF00023.30 PIK34494.1 - 0.0011 19.3 0.0 0.1 13.1 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat TAN PF11640.8 PIK34494.1 - 0.032 14.4 0.0 0.095 12.8 0.0 1.7 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair PRESAN PF09687.10 PIK34494.1 - 3 8.4 8.9 17 6.0 0.4 3.4 3 0 0 3 3 3 0 Plasmodium RESA N-terminal DUF4698 PF15769.5 PIK34495.1 - 6.1e-08 32.2 0.3 6.1e-08 32.2 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4698) DUF4698 PF15769.5 PIK34496.1 - 5.3e-25 88.4 20.7 1.4e-18 67.2 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4698) HTH_34 PF13601.6 PIK34496.1 - 0.15 12.2 0.5 0.43 10.8 0.0 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain DUF4661 PF15576.6 PIK34496.1 - 7.3 6.4 14.3 0.9 9.4 7.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4661) ADAM17_MPD PF16698.5 PIK34497.1 - 4e-12 46.3 14.1 4e-12 46.3 14.1 1.7 2 0 0 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 LRR_6 PF13516.6 PIK34498.1 - 2.2e-14 52.2 0.6 0.00033 20.5 0.0 6.6 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 PIK34498.1 - 3e-07 30.6 1.3 0.2 12.1 0.1 4.9 5 1 0 6 6 6 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK34498.1 - 0.00043 20.1 0.5 0.0011 18.8 0.5 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 PIK34498.1 - 0.0091 15.7 1.3 25 4.7 0.1 5.0 3 1 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 PIK34498.1 - 0.083 13.5 10.3 3.5 8.5 0.0 5.9 7 2 0 7 7 7 0 Leucine Rich Repeat G_glu_transpept PF01019.21 PIK34499.1 - 2.3e-135 452.3 0.0 2.8e-135 452.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RVT_1 PF00078.27 PIK34500.1 - 4.1e-29 101.7 0.0 7e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BatD PF13584.6 PIK34501.1 - 0.0063 15.4 0.2 0.009 14.9 0.2 1.1 1 0 0 1 1 1 1 Oxygen tolerance Peptidase_M10 PF00413.24 PIK34502.1 - 6.3e-48 162.6 0.1 2e-47 161.0 0.0 1.8 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.19 PIK34502.1 - 4.7e-16 58.5 7.7 1.1e-06 28.5 0.5 4.2 4 0 0 4 4 4 2 Hemopexin PG_binding_1 PF01471.18 PIK34502.1 - 8.2e-09 35.5 0.1 2.1e-08 34.3 0.1 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Metallopep PF12044.8 PIK34502.1 - 0.062 11.9 0.1 0.096 11.3 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 PIK34502.1 - 0.07 13.7 0.1 0.17 12.4 0.1 1.8 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 PIK34502.1 - 0.2 11.3 0.7 3.8 7.1 0.2 2.3 1 1 1 2 2 2 0 Astacin (Peptidase family M12A) LIM PF00412.22 PIK34503.1 - 4.4e-24 84.5 33.8 3.7e-09 36.7 5.4 3.1 3 0 0 3 3 3 3 LIM domain DUF3268 PF11672.8 PIK34503.1 - 6.3e-05 23.3 9.4 0.0021 18.4 0.3 3.0 3 0 0 3 3 3 2 zinc-finger-containing domain zf-ribbon_3 PF13248.6 PIK34503.1 - 0.026 13.9 0.2 0.026 13.9 0.2 4.7 7 0 0 7 7 7 0 zinc-ribbon domain DUF1272 PF06906.11 PIK34503.1 - 0.035 14.2 28.6 0.086 13.0 7.9 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1272) zf_UBZ PF18439.1 PIK34503.1 - 0.13 11.8 21.2 2.2 7.9 0.1 5.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_2 PF13240.6 PIK34503.1 - 0.26 11.0 0.2 0.26 11.0 0.2 4.7 7 0 0 7 7 7 0 zinc-ribbon domain Terminase_GpA PF05876.12 PIK34503.1 - 0.77 8.2 15.9 0.2 10.2 3.4 3.0 2 1 1 3 3 3 0 Phage terminase large subunit (GpA) zf-C3HC4_3 PF13920.6 PIK34503.1 - 4.4 7.3 36.7 0.37 10.7 9.3 4.7 2 1 2 4 4 4 0 Zinc finger, C3HC4 type (RING finger) LIM PF00412.22 PIK34504.1 - 2.7e-23 81.9 13.7 5.5e-12 45.7 1.1 2.1 2 0 0 2 2 2 2 LIM domain zf-dskA_traR PF01258.17 PIK34504.1 - 0.0014 18.5 1.3 0.0014 18.5 1.3 3.9 4 0 0 4 4 4 1 Prokaryotic dksA/traR C4-type zinc finger zf-RanBP PF00641.18 PIK34504.1 - 0.011 15.0 0.2 0.011 15.0 0.2 3.7 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others zf-CHY PF05495.12 PIK34504.1 - 0.22 12.0 15.9 1.6 9.3 3.5 2.1 1 1 1 2 2 2 0 CHY zinc finger Sgf11 PF08209.11 PIK34504.1 - 0.89 9.2 18.6 0.21 11.2 0.8 4.2 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) DUF2321 PF10083.9 PIK34504.1 - 1.4 8.5 8.0 0.79 9.3 6.2 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Siva PF05458.12 PIK34504.1 - 1.6 8.3 10.1 3.8 7.2 3.7 2.1 1 1 1 2 2 2 0 Cd27 binding protein (Siva) Auto_anti-p27 PF06677.12 PIK34504.1 - 3.8 7.7 15.5 0.27 11.4 1.2 3.3 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) RT_RNaseH PF17917.1 PIK34505.1 - 0.00083 19.6 0.1 0.0018 18.5 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TPMT PF05724.11 PIK34506.1 - 0.058 13.0 0.0 0.088 12.4 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Phage_integrase PF00589.22 PIK34507.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family zf-C2H2 PF00096.26 PIK34508.1 - 0.00099 19.4 5.8 0.003 17.9 5.8 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK34508.1 - 0.0011 19.2 2.1 0.0043 17.3 2.1 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK34508.1 - 0.0014 19.2 4.8 0.0064 17.2 4.8 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK34508.1 - 0.039 14.3 1.8 0.23 11.8 1.4 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Phage_lysozyme PF00959.19 PIK34508.1 - 0.11 12.9 0.1 1.9 9.0 0.0 2.2 2 0 0 2 2 2 0 Phage lysozyme zf-BED PF02892.15 PIK34508.1 - 0.21 11.6 4.8 0.56 10.3 4.8 1.7 1 0 0 1 1 1 0 BED zinc finger zf-Di19 PF05605.12 PIK34508.1 - 0.37 11.1 3.4 0.42 10.9 1.1 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding HGTP_anticodon PF03129.20 PIK34509.1 - 2.9e-13 49.8 0.5 3.6e-13 49.5 0.5 1.1 1 0 0 1 1 1 1 Anticodon binding domain TIM PF00121.18 PIK34509.1 - 0.017 14.5 0.2 0.018 14.4 0.2 1.2 1 0 0 1 1 1 0 Triosephosphate isomerase GTP_cyclohydroI PF01227.22 PIK34510.1 - 0.06 12.8 0.1 1.2 8.5 0.0 2.1 1 1 1 2 2 2 0 GTP cyclohydrolase I LacI PF00356.21 PIK34510.1 - 0.077 12.8 0.0 9.2 6.2 0.0 2.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Dynamin_M PF01031.20 PIK34510.1 - 0.087 12.0 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 Dynamin central region SepF PF04472.12 PIK34511.1 - 0.09 13.1 0.0 1.1 9.6 0.0 2.4 1 1 1 2 2 2 0 Cell division protein SepF SR-25 PF10500.9 PIK34511.1 - 6.1 6.4 13.0 9.4 5.8 13.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_S16 PF00886.19 PIK34512.1 - 2.6e-05 24.2 0.1 5.4e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S16 Reeler PF02014.16 PIK34513.1 - 6.5e-10 39.9 0.2 8.1e-10 39.6 0.2 1.1 1 0 0 1 1 1 1 Reeler domain Ephrin_rec_like PF07699.13 PIK34514.1 - 4.9e-12 45.4 10.6 3.6e-10 39.4 4.9 2.5 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK34514.1 - 0.0051 16.8 5.7 0.13 12.2 2.0 2.5 2 0 0 2 2 2 2 Nine Cysteines Domain of family 3 GPCR DUF2318 PF10080.9 PIK34514.1 - 0.19 11.8 4.3 5.2 7.3 0.4 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Opy2 PF09463.10 PIK34514.1 - 0.32 11.3 5.7 0.36 11.2 3.8 2.1 2 1 0 2 2 2 0 Opy2 protein CC PF04942.14 PIK34514.1 - 2.3 8.5 7.3 1 9.6 2.7 2.6 2 1 0 2 2 2 0 CC domain TNFR_c6 PF00020.18 PIK34514.1 - 8.5 6.9 8.6 10 6.6 2.2 2.8 2 1 1 3 3 3 0 TNFR/NGFR cysteine-rich region Pkinase_Tyr PF07714.17 PIK34515.1 - 3.6e-81 272.3 0.0 4.4e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34515.1 - 1e-38 133.3 0.0 1.4e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK34515.1 - 2e-20 72.6 0.0 4.2e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 PIK34515.1 - 0.014 14.8 0.0 0.034 13.6 0.0 1.4 1 1 0 1 1 1 0 SH2 domain Kinase-like PF14531.6 PIK34515.1 - 0.12 11.6 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like EamA PF00892.20 PIK34516.1 - 2.1e-13 50.6 24.8 1.2e-09 38.5 17.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 PIK34516.1 - 0.35 11.6 0.0 0.35 11.6 0.0 3.6 2 1 1 3 3 3 0 Small Multidrug Resistance protein TssN PF17555.2 PIK34516.1 - 5 6.4 10.4 2 7.8 8.2 1.5 1 1 0 1 1 1 0 Type VI secretion system, TssN Trehalase PF01204.18 PIK34517.1 - 5.8e-09 35.3 0.1 6.1e-09 35.2 0.1 1.1 1 0 0 1 1 1 1 Trehalase SRTM1 PF15872.5 PIK34517.1 - 0.036 14.2 0.1 0.053 13.7 0.1 1.2 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 DUF1554 PF07588.11 PIK34517.1 - 0.071 12.9 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1554) Trehalase PF01204.18 PIK34518.1 - 1.1e-80 271.9 0.7 1.2e-80 271.8 0.7 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 PIK34518.1 - 0.054 12.4 0.2 0.082 11.8 0.2 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase YjeJ PF15922.5 PIK34518.1 - 0.064 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 YjeJ-like Cut8 PF08559.10 PIK34519.1 - 5.9e-37 127.6 0.5 8.6e-37 127.0 0.5 1.2 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Presenilin PF01080.17 PIK34521.1 - 0.56 8.9 2.4 0.71 8.6 2.4 1.2 1 0 0 1 1 1 0 Presenilin Cwf_Cwc_15 PF04889.12 PIK34521.1 - 1.2 8.9 14.1 1.4 8.6 14.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Cwf_Cwc_15 PF04889.12 PIK34522.1 - 2.5 7.8 14.7 3.3 7.4 14.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Presenilin PF01080.17 PIK34522.1 - 2.6 6.7 4.1 3.5 6.3 4.1 1.2 1 0 0 1 1 1 0 Presenilin TIR_2 PF13676.6 PIK34524.1 - 0.0002 21.9 0.3 0.00037 21.1 0.3 1.5 1 1 0 1 1 1 1 TIR domain TIR PF01582.20 PIK34524.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 TIR domain TIR_2 PF13676.6 PIK34525.1 - 2.8e-34 118.2 0.5 2.3e-16 60.5 0.0 2.5 2 0 0 2 2 2 2 TIR domain TIR PF01582.20 PIK34525.1 - 4e-15 56.0 1.8 5.2e-07 29.6 0.2 2.5 2 0 0 2 2 2 2 TIR domain DUF1863 PF08937.11 PIK34525.1 - 0.017 15.4 0.4 0.083 13.2 0.1 2.2 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) TAF1D PF15333.6 PIK34525.1 - 0.092 12.5 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D DUF4062 PF13271.6 PIK34525.1 - 0.14 12.5 0.8 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) WD40 PF00400.32 PIK34526.1 - 6.3e-13 49.0 12.5 6.9e-07 29.9 0.1 5.2 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK34526.1 - 0.0004 20.6 0.9 0.15 12.4 0.4 2.6 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK34526.1 - 0.00069 19.5 0.5 0.17 11.8 0.2 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A ASH PF15780.5 PIK34526.1 - 0.13 12.5 2.1 0.15 12.2 1.2 1.5 1 1 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CAF1C_H4-bd PF12265.8 PIK34527.1 - 1.8e-12 47.4 0.0 2.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex T4bSS_IcmS PF12608.8 PIK34527.1 - 0.06 13.7 8.7 0.84 10.0 2.6 2.5 2 0 0 2 2 2 0 Type IVb secretion, IcmS, effector-recruitment SDA1 PF05285.12 PIK34527.1 - 1.3 8.3 12.9 1.8 7.9 4.4 2.1 2 0 0 2 2 2 0 SDA1 Sigma70_ner PF04546.13 PIK34527.1 - 7.5 6.4 13.0 0.14 12.0 1.2 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region RXT2_N PF08595.11 PIK34527.1 - 8.5 6.4 9.1 0.74 9.8 0.5 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal COX6A PF02046.15 PIK34528.1 - 0.022 15.2 0.0 0.041 14.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIa DUF2370 PF10176.9 PIK34528.1 - 0.21 11.2 0.0 0.65 9.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) 7tm_2 PF00002.24 PIK34529.1 - 1.6e-26 93.1 17.6 2.1e-26 92.7 17.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 PIK34529.1 - 0.094 12.0 11.6 0.16 11.2 10.2 2.0 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2839 PF10999.8 PIK34529.1 - 0.4 11.1 4.0 1.8 9.0 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) LRR_8 PF13855.6 PIK34530.1 - 1.3e-30 104.9 15.4 1.3e-13 50.5 0.6 4.3 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK34530.1 - 9.5e-13 48.2 6.2 3.1e-05 23.9 0.0 3.1 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK34530.1 - 7.4e-12 45.3 20.7 0.00015 22.1 0.2 4.7 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK34530.1 - 0.0002 20.9 3.6 0.046 13.2 1.5 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK34530.1 - 0.0055 17.1 9.7 39 5.4 0.2 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat NCD3G PF07562.14 PIK34530.1 - 0.82 9.7 12.8 1.3 9.1 1.1 3.1 2 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR ZFYVE21_C PF16696.5 PIK34531.1 - 0.0025 17.7 0.1 0.0034 17.3 0.1 1.1 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus EpoR_lig-bind PF09067.10 PIK34531.1 - 0.02 15.1 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding Acetyltransf_2 PF00797.17 PIK34532.1 - 9.6e-07 28.8 0.5 3.2e-06 27.1 0.5 1.9 1 1 0 1 1 1 1 N-acetyltransferase CUE PF02845.16 PIK34532.1 - 0.028 14.1 0.1 0.24 11.2 0.0 2.4 2 0 0 2 2 2 0 CUE domain MOR2-PAG1_C PF14225.6 PIK34533.1 - 0.0096 15.8 0.3 0.027 14.3 0.1 1.7 2 0 0 2 2 2 1 Cell morphogenesis C-terminal HEAT_EZ PF13513.6 PIK34534.1 - 3.7e-05 24.1 6.0 0.0026 18.2 0.0 4.5 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 PIK34534.1 - 0.00013 21.9 6.5 0.32 11.4 0.1 4.2 5 0 0 5 5 5 2 HEAT repeat RIX1 PF08167.12 PIK34534.1 - 0.003 17.3 0.0 0.0098 15.7 0.0 1.9 1 1 0 1 1 1 1 rRNA processing/ribosome biogenesis Adaptin_N PF01602.20 PIK34534.1 - 0.026 13.1 0.4 0.36 9.3 0.0 2.5 1 1 1 2 2 2 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 PIK34534.1 - 0.029 14.9 0.1 1.1 9.9 0.0 3.1 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 PIK34534.1 - 0.065 13.6 0.6 5.1 7.6 0.0 3.0 3 0 0 3 3 3 0 HEAT repeats TIP120 PF08623.10 PIK34534.1 - 0.08 12.7 0.5 6.1 6.6 0.0 3.0 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Cnd1 PF12717.7 PIK34534.1 - 0.092 12.8 1.3 0.76 9.8 0.0 2.9 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 PIK34534.1 - 0.13 11.4 3.7 0.49 9.4 1.3 2.3 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal Ecm29 PF13001.7 PIK34535.1 - 2.3e-109 366.3 0.0 6e-109 365.0 0.0 1.7 1 0 0 1 1 1 1 Proteasome stabiliser HEAT_EZ PF13513.6 PIK34535.1 - 4.2e-06 27.2 4.3 0.0076 16.7 0.0 6.8 8 0 0 8 8 8 1 HEAT-like repeat HEAT_2 PF13646.6 PIK34535.1 - 3.4e-05 24.2 0.1 0.55 10.7 0.0 5.4 5 1 1 6 6 6 1 HEAT repeats Arm PF00514.23 PIK34535.1 - 0.002 18.1 0.1 2.5 8.3 0.1 4.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 PIK34535.1 - 0.0034 17.9 0.0 0.9 10.2 0.0 3.4 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region SAM_KSR1 PF13543.6 PIK34535.1 - 0.028 14.6 0.1 0.091 12.9 0.1 1.9 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SapB_2 PF03489.17 PIK34535.1 - 0.16 12.1 0.2 0.63 10.2 0.0 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 RT_RNaseH PF17917.1 PIK34536.1 - 1.8e-07 31.4 0.0 5.3e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase SCAN PF02023.17 PIK34536.1 - 0.009 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 SCAN domain Ig_3 PF13927.6 PIK34537.1 - 5.9e-13 49.2 0.0 6.7e-07 29.8 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK34537.1 - 2.1e-09 37.3 0.0 0.0055 16.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK34537.1 - 3.8e-07 30.2 0.1 0.0024 18.0 0.0 3.6 3 2 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK34537.1 - 5.4e-07 29.9 0.0 0.044 14.1 0.0 3.3 2 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK34537.1 - 0.00025 21.2 0.4 0.055 13.7 0.1 3.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK34537.1 - 0.0053 16.3 0.1 0.018 14.6 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Herpes_gE PF02480.16 PIK34537.1 - 0.017 13.9 0.0 0.2 10.3 0.0 2.0 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E C2-set_2 PF08205.12 PIK34537.1 - 0.078 13.1 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain DUF498 PF04430.14 PIK34538.1 - 3.1e-30 104.5 0.0 4.2e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) DUF2552 PF10827.8 PIK34538.1 - 0.08 13.1 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2552) STIMATE PF12400.8 PIK34539.1 - 1.4e-13 51.5 13.1 1.3e-07 32.2 4.9 2.6 1 1 1 2 2 2 2 STIMATE family TMEM154 PF15102.6 PIK34539.1 - 0.0067 16.3 0.3 0.012 15.6 0.3 1.4 1 0 0 1 1 1 1 TMEM154 protein family Vpu PF00558.19 PIK34539.1 - 0.013 15.3 0.1 0.07 12.9 0.1 2.1 2 0 0 2 2 2 0 Vpu protein TMEM220 PF15071.6 PIK34539.1 - 0.014 16.1 3.0 0.067 14.0 3.0 2.1 1 1 0 1 1 1 0 Transmembrane family 220, helix LRRNT_2 PF08263.12 PIK34539.1 - 0.033 14.5 0.0 0.06 13.7 0.0 1.4 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Gcd10p PF04189.13 PIK34539.1 - 0.037 13.1 0.0 0.047 12.8 0.0 1.1 1 0 0 1 1 1 0 Gcd10p family YajC PF02699.15 PIK34539.1 - 0.095 12.6 5.0 4 7.4 1.2 3.3 2 1 1 3 3 3 0 Preprotein translocase subunit SAM_1 PF00536.30 PIK34540.1 - 3.2e-10 40.3 0.0 6e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SLED PF12140.8 PIK34540.1 - 5.5e-09 36.5 0.0 1.2e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 SLED domain SAM_2 PF07647.17 PIK34540.1 - 2.6e-06 27.4 0.0 2.2e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK34540.1 - 4.2e-05 23.4 0.0 9.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 PIK34540.1 - 0.014 15.7 0.2 0.029 14.6 0.2 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DUF4684 PF15736.5 PIK34540.1 - 0.71 8.5 4.3 0.47 9.1 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4684) Pox_A12 PF04651.13 PIK34540.1 - 7.9 6.5 11.7 7.7 6.5 0.5 2.5 3 0 0 3 3 3 0 Poxvirus A12 protein MBT PF02820.18 PIK34541.1 - 3e-50 168.4 0.4 8e-21 74.2 0.0 4.2 4 0 0 4 4 4 3 mbt repeat DUF3797 PF12677.7 PIK34541.1 - 0.011 15.6 0.3 0.025 14.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) FH2 PF02181.23 PIK34544.1 - 1.2e-59 202.4 9.7 1.2e-59 202.4 9.7 2.1 2 1 0 2 2 2 1 Formin Homology 2 Domain zf-CCHC PF00098.23 PIK34548.1 - 2.9e-06 27.1 16.1 0.0018 18.3 3.3 3.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK34548.1 - 4.5e-05 23.1 14.2 0.24 11.2 1.0 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34548.1 - 0.0016 18.2 0.2 0.0016 18.2 0.2 2.9 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK34548.1 - 0.52 10.6 12.5 0.24 11.6 6.7 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK34548.1 - 0.55 10.0 12.9 0.49 10.2 0.3 4.3 4 0 0 4 4 4 0 C2H2 zinc-finger Exo_endo_phos PF03372.23 PIK34549.1 - 0.12 11.8 0.8 0.2 11.1 0.8 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 PIK34550.1 - 0.0015 18.5 15.1 0.077 13.1 0.5 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK34550.1 - 0.012 15.3 0.8 0.012 15.3 0.8 2.3 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK34550.1 - 0.047 13.5 8.0 0.054 13.3 3.8 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK34550.1 - 0.14 12.2 12.8 0.18 11.8 1.6 3.3 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK34550.1 - 0.9 9.3 10.5 2.8 7.8 0.4 3.1 2 1 1 3 3 3 0 Zinc knuckle PLD_C PF12357.8 PIK34551.1 - 0.044 13.7 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 Phospholipase D C terminal KOG2701 PF09762.9 PIK34551.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) RVT_1 PF00078.27 PIK34552.1 - 5.4e-34 117.6 0.0 7.5e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Carbam_trans_C PF16861.5 PIK34552.1 - 0.029 14.0 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus zf-CCHC PF00098.23 PIK34554.1 - 4.3e-06 26.5 15.5 0.029 14.4 0.2 3.8 4 0 0 4 4 4 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK34554.1 - 0.0052 16.5 3.4 0.016 14.9 0.3 2.5 2 0 0 2 2 2 1 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK34554.1 - 0.021 14.7 8.0 0.12 12.2 4.4 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK34554.1 - 0.16 12.0 9.6 1.5 8.9 1.3 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK34554.1 - 0.24 11.2 8.7 4.5 7.1 0.4 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34554.1 - 0.62 10.0 0.0 0.62 10.0 0.0 3.2 3 0 0 3 3 3 0 Zinc knuckle PRANC PF09372.10 PIK34556.1 - 0.23 11.8 1.9 6 7.3 0.0 3.4 3 0 0 3 3 3 0 PRANC domain Peptidase_M29 PF02073.15 PIK34557.1 - 0.021 13.6 0.1 0.022 13.5 0.1 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) DUF1108 PF06531.11 PIK34558.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) Sushi PF00084.20 PIK34559.1 - 0.00087 19.8 0.3 0.0019 18.8 0.3 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Glycophorin_A PF01102.18 PIK34559.1 - 0.0085 16.3 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Glycophorin A SARAF PF06682.12 PIK34559.1 - 0.016 14.9 0.0 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis APP_N PF02177.16 PIK34559.1 - 0.11 12.8 0.5 0.16 12.4 0.1 1.5 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding EphA2_TM PF14575.6 PIK34559.1 - 0.15 13.0 0.0 0.23 12.3 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Acetyltransf_10 PF13673.7 PIK34560.1 - 6.5e-07 29.3 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PARP PF00644.20 PIK34560.1 - 9.4e-07 28.6 0.0 2.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Acetyltransf_1 PF00583.25 PIK34560.1 - 2.3e-06 27.8 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK34560.1 - 0.0013 19.1 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 PIK34560.1 - 0.051 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Cwf_Cwc_15 PF04889.12 PIK34560.1 - 1.2 8.8 13.1 2.3 7.9 13.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Hist_deacetyl PF00850.19 PIK34561.1 - 3.9e-34 118.5 0.2 4.8e-34 118.2 0.2 1.0 1 0 0 1 1 1 1 Histone deacetylase domain TGT PF01702.18 PIK34563.1 - 9e-103 344.1 0.1 1.1e-102 343.8 0.1 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase RVT_1 PF00078.27 PIK34564.1 - 1.5e-42 145.6 1.3 1.5e-42 145.6 1.3 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L9_C PF03948.14 PIK34564.1 - 0.29 11.6 1.9 0.38 11.2 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L9, C-terminal domain DUF1759 PF03564.15 PIK34565.1 - 0.00018 21.4 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) KCNQC3-Ank-G_bd PF11956.8 PIK34565.1 - 0.15 12.4 0.1 2.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Ankyrin-G binding motif of KCNQ2-3 LRR_4 PF12799.7 PIK34567.1 - 1.7e-05 25.1 3.7 0.00054 20.3 0.5 2.6 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK34567.1 - 0.011 15.5 0.9 0.021 14.6 0.9 1.5 1 0 0 1 1 1 0 Leucine rich repeat PDZ PF00595.24 PIK34568.1 - 3.2e-31 107.5 4.4 2.4e-15 56.6 0.2 3.8 3 1 1 4 4 4 3 PDZ domain PDZ_6 PF17820.1 PIK34568.1 - 1.8e-12 46.9 0.3 1e-05 25.3 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK34568.1 - 7.8e-06 26.1 0.0 0.11 12.8 0.0 3.5 3 0 0 3 3 3 2 PDZ domain DUF4633 PF15464.6 PIK34568.1 - 0.13 12.4 2.8 0.35 11.0 2.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) Acyl-CoA_dh_M PF02770.19 PIK34569.1 - 6.4e-12 45.5 0.0 2.2e-11 43.8 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 PIK34569.1 - 1.2e-06 29.1 1.0 2.2e-06 28.3 1.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal ECR1_N PF14382.6 PIK34569.1 - 0.098 12.5 1.7 0.29 11.0 1.7 1.8 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region ACOX PF01756.19 PIK34570.1 - 1.1e-57 194.5 0.2 1.6e-57 194.0 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA oxidase Peptidase_C98 PF15499.6 PIK34571.1 - 1.5e-66 224.7 11.0 9e-66 222.1 11.0 2.0 1 1 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase FKBP_C PF00254.28 PIK34572.1 - 0.035 14.4 0.0 0.042 14.2 0.0 1.4 1 1 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase Orf78 PF06024.12 PIK34572.1 - 0.047 14.0 0.0 0.073 13.4 0.0 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Amidase PF01425.21 PIK34573.1 - 9.3e-77 258.9 0.2 1.1e-76 258.6 0.2 1.0 1 0 0 1 1 1 1 Amidase MULE PF10551.9 PIK34575.1 - 0.0096 16.3 0.5 0.037 14.5 0.0 2.2 4 0 0 4 4 4 1 MULE transposase domain T2SS_PulS_OutS PF09691.10 PIK34576.1 - 0.00017 21.7 0.1 0.00022 21.4 0.1 1.1 1 0 0 1 1 1 1 Type II secretion system pilotin lipoprotein (PulS_OutS) DUF2046 PF09755.9 PIK34576.1 - 0.035 13.3 0.3 0.037 13.2 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) RT_RNaseH PF17917.1 PIK34577.1 - 0.0012 19.1 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MLVIN_C PF18697.1 PIK34578.1 - 0.034 14.2 0.3 0.066 13.3 0.3 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF2199 PF09965.9 PIK34578.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2199) FMN_dh PF01070.18 PIK34579.1 - 4.4e-68 229.9 0.1 5e-68 229.7 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK34579.1 - 9.2e-10 38.0 2.1 1.3e-09 37.5 2.1 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK34579.1 - 1.5e-05 24.3 0.0 2.4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK34579.1 - 8.9e-05 22.0 0.7 0.00013 21.5 0.7 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase Dus PF01207.17 PIK34579.1 - 0.00011 21.5 0.4 0.25 10.4 0.1 3.1 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 PIK34579.1 - 0.00034 20.1 0.7 0.011 15.2 0.1 2.5 2 1 1 3 3 3 1 Histidine biosynthesis protein ThiG PF05690.14 PIK34579.1 - 0.0015 17.9 0.6 0.97 8.7 0.1 2.3 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 PIK34579.1 - 0.024 14.1 0.1 5.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator TMP-TENI PF02581.17 PIK34579.1 - 0.081 12.2 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Thiamine monophosphate synthase DHO_dh PF01180.21 PIK34579.1 - 0.2 10.8 0.4 0.56 9.4 0.1 1.7 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase FMN_dh PF01070.18 PIK34580.1 - 1.8e-19 70.0 0.0 2.1e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase FMN_dh PF01070.18 PIK34581.1 - 3.5e-112 374.9 0.5 4.1e-112 374.7 0.5 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK34581.1 - 6e-11 41.9 0.8 1.8e-09 37.1 0.2 2.2 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK34581.1 - 9.1e-06 25.0 0.1 1.6e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK34581.1 - 0.00021 20.8 1.4 0.00034 20.1 1.4 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK34581.1 - 0.015 14.8 0.7 0.13 11.6 0.0 2.4 2 1 1 3 3 3 0 Histidine biosynthesis protein DHO_dh PF01180.21 PIK34581.1 - 0.026 13.7 2.4 0.79 8.9 0.1 3.3 4 0 0 4 4 4 0 Dihydroorotate dehydrogenase Dus PF01207.17 PIK34581.1 - 0.031 13.4 0.3 1.2 8.2 0.1 2.4 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) ThiG PF05690.14 PIK34581.1 - 0.043 13.1 1.2 0.6 9.4 0.0 2.3 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Peptidase_M49 PF03571.15 PIK34582.1 - 0.13 10.6 0.0 0.15 10.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M49 Cep57_CLD_2 PF14197.6 PIK34582.1 - 1.6 8.9 5.2 0.33 11.1 0.6 2.2 2 2 0 2 2 2 0 Centrosome localisation domain of PPC89 Death PF00531.22 PIK34583.1 - 9.2e-07 28.9 0.1 1.1e-06 28.7 0.1 1.1 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK34584.1 - 1.9e-12 47.3 0.0 3.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK34584.1 - 2.3e-11 43.7 1.8 4.8e-11 42.7 1.8 1.5 1 0 0 1 1 1 1 Death domain NACHT PF05729.12 PIK34585.1 - 7.3e-15 55.3 0.0 1.7e-14 54.1 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK34585.1 - 4.5e-05 23.1 0.0 0.00013 21.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 PIK34585.1 - 0.0059 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DAP3 PF10236.9 PIK34585.1 - 0.025 13.7 0.0 0.077 12.1 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 IstB_IS21 PF01695.17 PIK34585.1 - 0.04 13.6 0.0 0.71 9.6 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_14 PF13173.6 PIK34585.1 - 0.063 13.3 0.2 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain TrmB PF01978.19 PIK34585.1 - 0.079 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ATPase PF06745.13 PIK34585.1 - 0.099 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 PIK34585.1 - 0.099 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 PIK34585.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 PIK34585.1 - 0.11 11.8 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 PIK34585.1 - 0.12 11.7 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Aldedh PF00171.22 PIK34586.1 - 8.5e-163 542.1 0.3 9.6e-163 542.0 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RGS-like PF09128.11 PIK34587.1 - 3.9e-39 134.3 0.1 4.7e-39 134.0 0.1 1.0 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain RGS PF00615.19 PIK34587.1 - 8e-10 39.0 0.3 1.1e-09 38.6 0.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Thioredoxin_14 PF18402.1 PIK34587.1 - 0.017 15.1 0.1 0.02 14.9 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain HHH_3 PF12836.7 PIK34587.1 - 0.029 14.6 0.0 5.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF773 PF05600.12 PIK34587.1 - 0.035 12.8 0.2 0.047 12.4 0.2 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Peptidase_M16 PF00675.20 PIK34587.1 - 0.071 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) C1_1 PF00130.22 PIK34588.1 - 4.5e-12 45.7 3.6 7.4e-12 45.0 3.6 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Fer4_16 PF13484.6 PIK34588.1 - 0.2 12.6 0.2 0.2 12.6 0.2 2.1 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain C1_2 PF03107.16 PIK34588.1 - 0.21 12.0 1.6 0.37 11.1 1.6 1.4 1 0 0 1 1 1 0 C1 domain RhoGEF PF00621.20 PIK34589.1 - 3.3e-25 89.4 2.6 1.1e-12 48.6 0.4 2.6 1 1 1 2 2 2 2 RhoGEF domain PH_16 PF17838.1 PIK34589.1 - 3.7e-18 65.6 0.2 1.1e-17 64.0 0.0 1.9 2 0 0 2 2 2 1 PH domain BRE1 PF08647.11 PIK34589.1 - 2.7 8.1 6.3 4 7.6 0.5 3.1 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase YTV PF07639.11 PIK34590.1 - 0.12 12.5 4.2 0.31 11.1 4.2 1.7 1 0 0 1 1 1 0 YTV PilJ PF13675.6 PIK34590.1 - 0.16 12.0 1.3 1.2 9.2 1.0 2.4 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3456 PF11938.8 PIK34590.1 - 0.68 10.4 4.1 0.3 11.6 1.5 1.7 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP REV PF00424.18 PIK34591.1 - 0.023 14.7 1.0 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Exo_endo_phos PF03372.23 PIK34591.1 - 0.075 12.5 4.0 0.11 12.0 3.1 1.7 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Keratin_2_head PF16208.5 PIK34591.1 - 1.1 9.4 40.1 1.6 8.9 40.1 1.2 1 0 0 1 1 1 0 Keratin type II head Caa3_CtaG PF09678.10 PIK34592.1 - 0.00034 20.2 1.5 0.00047 19.7 1.2 1.3 1 1 0 1 1 1 1 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) DUF373 PF04123.13 PIK34592.1 - 0.021 14.3 4.5 0.028 13.9 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Tetraspanin PF00335.20 PIK34592.1 - 0.063 13.0 11.5 0.026 14.3 5.4 2.0 2 0 0 2 2 2 0 Tetraspanin family TMEM174 PF15029.6 PIK34592.1 - 0.11 12.2 1.2 0.11 12.2 0.5 1.5 1 1 0 1 1 1 0 Transmembrane protein 174 MscS_TM PF12794.7 PIK34592.1 - 0.12 11.2 3.0 0.15 10.8 3.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4064 PF13273.6 PIK34592.1 - 0.49 10.7 13.5 2.6 8.4 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF997 PF06196.12 PIK34592.1 - 0.52 10.4 5.5 0.19 11.8 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF997) DUF2157 PF09925.9 PIK34592.1 - 1.2 8.9 5.9 7.8 6.3 5.9 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Saf_2TM PF18303.1 PIK34592.1 - 3 7.4 9.1 0.11 12.1 1.5 2.2 1 1 2 3 3 3 0 SAVED-fused 2TM effector domain DUF872 PF05915.12 PIK34592.1 - 4.1 7.6 5.3 2 8.6 0.8 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Ig_3 PF13927.6 PIK34593.1 - 1.8e-05 25.2 0.2 0.00028 21.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK34593.1 - 0.00026 21.2 1.9 0.0069 16.7 0.1 3.1 2 1 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK34593.1 - 0.00083 19.5 0.2 0.0046 17.1 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK34593.1 - 0.0031 17.7 0.3 0.021 15.0 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.5 PIK34593.1 - 0.082 13.3 1.5 0.32 11.4 0.2 2.6 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain EOS1 PF12326.8 PIK34593.1 - 0.082 12.8 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 N-glycosylation protein RVT_1 PF00078.27 PIK34594.1 - 5.2e-26 91.5 0.3 1.1e-25 90.5 0.3 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK34594.1 - 3.9e-25 87.8 0.0 9.2e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34594.1 - 8.6e-18 64.6 0.0 2.2e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Abhydrolase_2 PF02230.16 PIK34595.1 - 1.2e-18 67.7 0.0 1.5e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 PIK34595.1 - 3.5e-05 23.2 0.0 3.5e-05 23.2 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK34595.1 - 6.8e-05 22.6 0.0 7.1e-05 22.6 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 PIK34595.1 - 0.00012 22.0 0.0 0.00013 21.9 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 PIK34595.1 - 0.00047 18.9 0.0 0.00049 18.9 0.0 1.0 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DUF2974 PF11187.8 PIK34595.1 - 0.0027 17.3 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 PIK34595.1 - 0.0028 18.3 0.0 0.0028 18.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.22 PIK34595.1 - 0.011 15.8 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 0 Cutinase Abhydrolase_5 PF12695.7 PIK34595.1 - 0.031 14.0 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 PIK34595.1 - 0.033 13.8 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Putative esterase DUF1057 PF06342.12 PIK34595.1 - 0.09 11.8 0.0 0.097 11.7 0.0 1.0 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Lipase_3 PF01764.25 PIK34595.1 - 0.19 11.6 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) DUF4470 PF14737.6 PIK34596.1 - 8.1e-17 61.2 0.1 1.7e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 PIK34596.1 - 3.1e-11 43.2 31.7 4.8e-08 33.0 12.7 2.8 2 0 0 2 2 2 2 MYND finger ADAM_spacer1 PF05986.14 PIK34600.1 - 1.2e-22 80.1 0.0 1.9e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 PIK34601.1 - 9.7e-05 22.5 12.6 0.0053 16.9 3.1 2.6 2 0 0 2 2 2 2 Thrombospondin type 1 domain TSP_1 PF00090.19 PIK34602.1 - 0.00029 21.0 6.0 0.00029 21.0 6.0 2.3 3 0 0 3 3 3 1 Thrombospondin type 1 domain Cnd1 PF12717.7 PIK34603.1 - 2e-08 34.5 4.3 2.2e-05 24.5 0.6 4.0 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 PIK34603.1 - 4.6e-08 32.6 2.0 0.0019 18.3 0.1 4.0 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 PIK34603.1 - 3.7e-06 27.2 0.0 0.11 12.8 0.0 2.7 2 0 0 2 2 2 2 HEAT repeats Cohesin_HEAT PF12765.7 PIK34603.1 - 4.6e-06 26.8 0.6 0.43 10.9 0.0 3.9 4 0 0 4 4 4 3 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 PIK34603.1 - 0.028 13.0 3.8 0.093 11.3 0.3 2.8 3 0 0 3 3 3 0 Adaptin N terminal region HBS1_N PF08938.10 PIK34603.1 - 0.072 13.4 0.9 0.2 12.0 0.9 1.7 1 0 0 1 1 1 0 HBS1 N-terminus RTP1_C1 PF10363.9 PIK34603.1 - 0.19 11.9 2.5 18 5.5 0.0 3.2 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3246 PF11596.8 PIK34604.1 - 0.03 13.8 2.8 2.8 7.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) DUF2714 PF10896.8 PIK34604.1 - 0.17 12.0 0.4 0.36 10.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2714) WAPL PF07814.13 PIK34605.1 - 5.6e-39 134.0 9.7 2.1e-37 128.8 9.7 2.3 1 1 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Wap1 PF16997.5 PIK34605.1 - 0.0061 15.8 5.1 0.011 15.0 5.1 1.4 1 0 0 1 1 1 1 Wap1 domain Atx10homo_assoc PF09759.9 PIK34605.1 - 0.012 15.6 3.2 2.8 8.0 0.1 3.8 3 1 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain KH_1 PF00013.29 PIK34607.1 - 3.4e-15 55.6 2.4 6.5e-15 54.7 2.4 1.5 1 0 0 1 1 1 1 KH domain FliE PF02049.18 PIK34607.1 - 0.014 15.6 0.6 0.029 14.5 0.6 1.5 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE KH_4 PF13083.6 PIK34607.1 - 0.044 13.7 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 KH domain KH_2 PF07650.17 PIK34607.1 - 0.048 13.5 0.6 0.089 12.6 0.6 1.5 1 1 0 1 1 1 0 KH domain Ribosomal_S11 PF00411.19 PIK34607.1 - 0.062 13.7 1.0 1.7 9.1 0.1 2.2 1 1 1 2 2 2 0 Ribosomal protein S11 SPATIAL PF15256.6 PIK34607.1 - 0.25 11.6 3.3 0.3 11.4 2.5 1.4 1 1 0 1 1 1 0 SPATIAL Ank_2 PF12796.7 PIK34608.1 - 1.1e-36 125.2 3.6 6.7e-12 45.8 0.3 4.4 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK34608.1 - 3.2e-34 116.9 0.2 1.4e-07 31.9 0.0 6.2 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK34608.1 - 1e-30 104.8 5.7 1.2e-05 25.5 0.2 6.5 6 1 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK34608.1 - 8.7e-27 92.8 1.2 6e-06 26.4 0.0 6.4 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK34608.1 - 3.4e-26 88.4 1.9 1.9e-05 24.7 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat Neugrin PF06413.11 PIK34608.1 - 0.4 10.7 12.6 0.014 15.4 5.1 2.2 2 0 0 2 2 2 0 Neugrin eIF-3c_N PF05470.12 PIK34608.1 - 1.4 7.1 14.8 2.9 6.1 14.8 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus AP3D1 PF06375.11 PIK34608.1 - 2.7 8.2 26.5 1.1 9.5 12.8 2.7 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 NHL PF01436.21 PIK34609.1 - 2.6e-27 93.4 10.2 1.4e-07 31.2 1.6 4.7 4 0 0 4 4 4 4 NHL repeat DUF5128 PF17170.4 PIK34609.1 - 4.6e-12 45.7 0.1 0.00028 20.1 0.1 3.5 1 1 1 3 3 3 3 6-bladed beta-propeller SGL PF08450.12 PIK34609.1 - 6.6e-08 32.4 0.2 0.00023 20.8 0.0 3.4 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region zf-RING_5 PF14634.6 PIK34609.1 - 1e-07 31.8 9.2 2.5e-07 30.5 9.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK34609.1 - 5.2e-07 29.9 9.7 1.7e-06 28.3 9.7 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK34609.1 - 1.2e-06 28.5 8.9 4.1e-06 26.7 8.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK34609.1 - 3e-06 27.0 9.9 7.5e-06 25.7 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SBBP PF06739.11 PIK34609.1 - 8.4e-06 25.7 0.1 0.04 13.9 0.0 3.2 3 0 0 3 3 3 2 Beta-propeller repeat zf-C3HC4_2 PF13923.6 PIK34609.1 - 2.5e-05 24.0 10.9 5.9e-05 22.8 10.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4934 PF16288.5 PIK34609.1 - 0.00055 19.8 1.7 2.5 8.0 0.0 3.4 1 1 3 4 4 4 2 Domain of unknown function (DUF4934) zf-C3HC4_4 PF15227.6 PIK34609.1 - 0.0014 18.7 10.4 0.0014 18.7 10.4 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 PIK34609.1 - 0.005 16.6 8.6 0.011 15.5 8.6 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Methyltrans_RNA PF04452.14 PIK34609.1 - 0.0099 15.2 0.1 0.019 14.3 0.1 1.4 1 0 0 1 1 1 1 RNA methyltransferase Angiomotin_C PF12240.8 PIK34609.1 - 0.032 13.8 3.3 0.053 13.1 3.3 1.3 1 0 0 1 1 1 0 Angiomotin C terminal zf-RING_11 PF17123.5 PIK34609.1 - 0.39 10.5 4.5 1.3 8.8 4.5 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 PIK34609.1 - 2 8.8 9.1 12 6.2 9.1 2.5 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 PIK34609.1 - 2.2 8.2 10.7 18 5.3 11.1 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DNA_primase_lrg PF04104.14 PIK34610.1 - 3.1e-19 69.4 0.3 4.1e-19 69.0 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DNA_primase_lrg PF04104.14 PIK34611.1 - 2.6e-49 168.0 0.5 5e-49 167.1 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit LisH_TPL PF17814.1 PIK34611.1 - 0.068 12.8 0.0 0.65 9.7 0.0 2.4 2 0 0 2 2 2 0 LisH-like dimerisation domain ADH_N PF08240.12 PIK34612.1 - 2.6e-10 40.2 0.1 7e-10 38.8 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK34612.1 - 3e-09 36.9 0.0 5.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 PIK34612.1 - 0.15 12.0 0.2 0.69 9.8 0.1 2.1 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase ATG16 PF08614.11 PIK34613.1 - 0.014 15.6 0.2 0.018 15.3 0.2 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) HYR PF02494.16 PIK34615.1 - 2.2e-27 95.2 8.3 5.6e-21 74.7 1.1 2.7 2 0 0 2 2 2 2 HYR domain EGF PF00008.27 PIK34615.1 - 9.7e-25 86.5 72.5 1.5e-07 31.5 11.7 5.5 6 0 0 6 6 6 4 EGF-like domain EGF_2 PF07974.13 PIK34615.1 - 3.2e-11 43.4 69.7 0.00081 19.7 11.6 5.2 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 PIK34615.1 - 1.6e-09 38.0 76.8 0.00026 21.5 7.6 6.9 8 0 0 8 8 8 4 Human growth factor-like EGF cEGF PF12662.7 PIK34615.1 - 0.00087 19.2 43.8 0.2 11.6 2.3 5.4 5 0 0 5 5 5 4 Complement Clr-like EGF-like CheC PF04509.12 PIK34615.1 - 9.3 6.3 6.5 1.3e+02 2.5 0.0 4.0 4 0 0 4 4 4 0 CheC-like family HYR PF02494.16 PIK34616.1 - 1.3e-66 220.9 47.2 9e-24 83.6 4.9 5.1 5 0 0 5 5 5 4 HYR domain fn3 PF00041.21 PIK34616.1 - 0.0025 18.1 6.9 0.3 11.4 0.1 3.9 3 1 0 3 3 3 1 Fibronectin type III domain Lantibiotic_a PF14867.6 PIK34616.1 - 0.0043 16.8 0.8 1.5 8.6 0.1 3.4 2 0 0 2 2 2 1 Lantibiotic alpha PA_decarbox PF05870.11 PIK34616.1 - 0.028 14.1 0.3 0.18 11.4 0.0 2.3 3 0 0 3 3 3 0 Phenolic acid decarboxylase (PAD) Autoind_bind PF03472.15 PIK34616.1 - 0.089 12.3 0.2 7.2 6.1 0.0 2.9 3 0 0 3 3 3 0 Autoinducer binding domain p31comet PF06581.12 PIK34616.1 - 0.11 11.6 2.2 16 4.6 0.0 3.1 3 0 0 3 3 3 0 Mad1 and Cdc20-bound-Mad2 binding FAM153 PF15722.5 PIK34616.1 - 0.2 12.0 0.7 53 4.2 0.0 3.6 4 0 0 4 4 4 0 FAM153 family HYR PF02494.16 PIK34617.1 - 1.4e-102 336.1 43.2 2.2e-24 85.6 2.7 8.1 7 1 1 8 8 8 8 HYR domain DUF5011 PF16403.5 PIK34617.1 - 0.0075 16.4 0.9 47 4.2 0.0 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) SPR1 PF15356.6 PIK34617.1 - 0.37 11.3 3.0 0.25 11.9 0.3 2.1 2 0 0 2 2 2 0 Psoriasis susceptibility locus 2 Big_8 PF17961.1 PIK34617.1 - 0.94 9.7 5.9 11 6.3 0.1 3.8 4 0 0 4 4 4 0 Bacterial Ig domain HYR PF02494.16 PIK34618.1 - 2.4e-152 495.6 58.3 2.6e-25 88.5 3.1 7.0 7 0 0 7 7 7 7 HYR domain SH3_12 PF18129.1 PIK34618.1 - 0.0012 18.9 7.3 4.4 7.5 0.1 3.9 4 0 0 4 4 4 3 Xrn1 SH3-like domain Maelstrom PF13017.6 PIK34618.1 - 0.0023 17.6 0.2 8.1 6.0 0.0 3.1 2 1 0 3 3 3 2 piRNA pathway germ-plasm component PA_decarbox PF05870.11 PIK34618.1 - 0.057 13.0 1.3 2.5 7.7 0.0 3.6 5 0 0 5 5 5 0 Phenolic acid decarboxylase (PAD) Cadherin_3 PF16184.5 PIK34618.1 - 5.7 7.0 17.6 19 5.3 0.1 5.7 6 0 0 6 6 6 0 Cadherin-like IgGFc_binding PF17517.2 PIK34619.1 - 1.4e-06 27.8 0.9 1.5e-05 24.4 0.1 2.2 1 1 1 2 2 2 2 IgGFc binding protein AhpC-TSA PF00578.21 PIK34620.1 - 1.1e-41 141.6 0.0 1.5e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK34620.1 - 3.5e-17 62.5 0.0 4.8e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 PIK34620.1 - 7.7e-08 32.1 0.1 1.5e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 PIK34620.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 SCO1/SenC DM PF00751.18 PIK34621.1 - 1.5e-22 79.2 13.0 2.1e-22 78.7 13.0 1.2 1 0 0 1 1 1 1 DM DNA binding domain Baculo_VP91_N PF08475.10 PIK34622.1 - 6.4 6.4 5.9 2.7 7.7 0.9 2.3 2 0 0 2 2 2 0 Viral capsid protein 91 N-terminal Ig_2 PF13895.6 PIK34623.1 - 3.7e-11 43.2 0.2 3.1e-06 27.4 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK34623.1 - 1.1e-06 29.2 6.3 0.00031 21.3 0.0 3.2 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK34623.1 - 1.2e-05 25.5 0.2 0.078 13.1 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.16 PIK34623.1 - 0.0017 18.4 0.0 0.021 14.9 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain RIFIN PF02009.16 PIK34623.1 - 0.0018 18.2 0.3 0.0026 17.7 0.3 1.2 1 0 0 1 1 1 1 Rifin Protocadherin PF08374.11 PIK34623.1 - 0.0057 16.7 0.2 0.01 15.9 0.2 1.3 1 0 0 1 1 1 1 Protocadherin DUF5305 PF17231.2 PIK34623.1 - 0.027 13.9 2.8 0.074 12.4 2.8 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Baculo_11_kDa PF06143.11 PIK34623.1 - 0.032 13.8 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM154 PF15102.6 PIK34623.1 - 0.036 14.0 5.0 0.07 13.0 5.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Peptidase_M56 PF05569.11 PIK34623.1 - 0.048 12.8 0.4 0.075 12.2 0.4 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 EphA2_TM PF14575.6 PIK34623.1 - 0.07 14.0 0.2 0.18 12.7 0.2 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AJAP1_PANP_C PF15298.6 PIK34623.1 - 0.24 11.6 12.7 0.39 10.9 12.1 1.6 1 1 0 1 1 1 0 AJAP1/PANP C-terminus ig PF00047.25 PIK34623.1 - 0.3 11.3 3.9 11 6.3 0.0 3.4 4 0 0 4 4 3 0 Immunoglobulin domain Vpu PF00558.19 PIK34623.1 - 0.45 10.3 3.1 0.88 9.4 3.1 1.4 1 0 0 1 1 1 0 Vpu protein DUF4668 PF15701.5 PIK34623.1 - 0.94 9.3 4.8 0.15 11.9 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4668) DUF4106 PF13388.6 PIK34623.1 - 9.2 5.4 7.7 14 4.8 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) zf-CCHC PF00098.23 PIK34624.1 - 0.0038 17.2 0.3 0.0038 17.2 0.3 2.2 2 0 0 2 2 2 1 Zinc knuckle HTH_21 PF13276.6 PIK34624.1 - 0.059 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 HTH-like domain zf-CCHC_5 PF14787.6 PIK34624.1 - 4.8 7.0 7.5 0.91 9.3 3.7 1.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF737 PF05300.11 PIK34624.1 - 5.2 7.4 10.0 57 4.0 9.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF737) IQ PF00612.27 PIK34625.1 - 0.022 14.5 0.4 0.081 12.8 0.4 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Neurexophilin PF06312.12 PIK34626.1 - 1.8e-12 47.2 0.2 2.9e-12 46.5 0.2 1.3 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 PIK34626.1 - 0.0073 17.1 0.0 0.017 15.9 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF2183 PF09949.9 PIK34626.1 - 0.029 14.7 0.0 0.93 9.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) rve PF00665.26 PIK34627.1 - 1.7e-09 37.9 0.0 2.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK34627.1 - 0.0042 16.8 0.0 0.007 16.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK34627.1 - 0.013 15.8 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK34628.1 - 1.4e-17 64.0 0.0 2.2e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LIM PF00412.22 PIK34629.1 - 2e-28 98.4 25.3 3e-13 49.8 4.2 3.8 3 1 0 3 3 3 3 LIM domain Glyco_transf_29 PF00777.18 PIK34631.1 - 3.7e-22 79.0 1.6 3.7e-22 79.0 1.6 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) RVT_1 PF00078.27 PIK34632.1 - 6.2e-12 45.5 0.0 1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PARP PF00644.20 PIK34633.1 - 2.5e-12 46.8 0.0 6.9e-12 45.4 0.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Acetyltransf_10 PF13673.7 PIK34633.1 - 4.8e-06 26.5 0.0 9.1e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK34633.1 - 0.00071 19.8 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK34633.1 - 0.0049 17.3 0.0 0.0096 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 PIK34633.1 - 0.084 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Hist_deacetyl PF00850.19 PIK34634.1 - 1.1e-68 232.1 0.3 3e-68 230.6 0.1 1.8 2 0 0 2 2 2 1 Histone deacetylase domain Pkinase PF00069.25 PIK34635.1 - 8e-61 205.7 0.0 8e-61 205.7 0.0 3.6 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK34635.1 - 3.7e-31 108.3 0.0 3.7e-31 108.3 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.11 PIK34635.1 - 1.3e-09 38.7 16.6 1.3e-09 38.7 16.6 13.0 5 1 5 10 10 10 1 Rho Binding APH PF01636.23 PIK34635.1 - 0.0005 20.1 0.3 0.0039 17.1 0.2 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family C1_1 PF00130.22 PIK34635.1 - 0.00057 19.7 5.8 0.0013 18.5 5.8 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 PIK34635.1 - 0.014 16.1 1.9 0.048 14.4 1.9 2.0 1 0 0 1 1 1 0 Protein kinase C terminal domain PH PF00169.29 PIK34635.1 - 0.018 15.5 0.1 1.8 9.2 0.0 3.3 2 0 0 2 2 2 0 PH domain DUF2293 PF10056.9 PIK34635.1 - 0.059 13.6 0.5 0.28 11.5 0.5 2.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) Dimer_Tnp_hAT PF05699.14 PIK34636.1 - 3.4e-07 30.0 0.1 2.5e-06 27.2 0.1 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Fumerase_C PF05683.12 PIK34637.1 - 2.1e-55 187.3 0.0 3.5e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 PIK34637.1 - 1.6e-34 119.6 0.0 2.1e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) RVT_1 PF00078.27 PIK34638.1 - 3.3e-30 105.3 2.0 1.1e-23 84.0 0.2 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) FAD_binding_7 PF03441.14 PIK34639.1 - 6.9e-77 257.5 0.2 1.1e-76 256.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 PIK34639.1 - 1.1e-18 67.8 0.0 2.4e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase ARID PF01388.21 PIK34640.1 - 0.11 13.1 0.6 0.13 13.0 0.6 1.1 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain KH_5 PF13184.6 PIK34640.1 - 0.14 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 NusA-like KH domain TMEM138 PF14935.6 PIK34641.1 - 5.4e-47 159.3 12.2 5.4e-47 159.3 12.2 1.5 2 0 0 2 2 2 1 Transmembrane protein 138 Gal-3-0_sulfotr PF06990.11 PIK34642.1 - 9.5e-54 182.8 0.0 1.1e-53 182.6 0.0 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase HIT PF01230.23 PIK34644.1 - 2e-30 105.4 0.1 2.7e-30 105.0 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 PIK34644.1 - 6.8e-26 91.0 0.1 9.2e-26 90.6 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding adh_short PF00106.25 PIK34645.1 - 4.7e-19 68.6 1.1 4.3e-17 62.2 0.0 3.0 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK34645.1 - 2.1e-11 43.9 0.1 6e-09 35.8 0.0 2.8 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 PIK34645.1 - 0.056 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ARTD15_N PF18084.1 PIK34646.1 - 0.00029 21.0 0.2 0.00072 19.8 0.2 1.7 1 0 0 1 1 1 1 ARTD15 N-terminal domain Phage_int_SAM_4 PF13495.6 PIK34646.1 - 0.008 16.6 0.0 0.017 15.6 0.0 1.6 1 1 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK34646.1 - 0.037 14.3 1.3 0.044 14.1 0.1 1.8 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Raftlin PF15250.6 PIK34648.1 - 0.044 12.5 0.0 0.06 12.1 0.0 1.1 1 0 0 1 1 1 0 Raftlin HAD_2 PF13419.6 PIK34650.1 - 1.3e-08 35.2 0.0 3.4e-08 33.8 0.0 1.7 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK34650.1 - 0.065 13.5 0.2 0.42 10.9 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Inhibitor_I34 PF10466.9 PIK34650.1 - 0.2 12.2 2.2 6.5 7.4 0.9 2.4 2 0 0 2 2 2 0 Saccharopepsin inhibitor I34 rve PF00665.26 PIK34652.1 - 1.4e-23 83.4 0.0 1.9e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK34652.1 - 6.9e-17 61.3 0.8 6.9e-17 61.3 0.8 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK34652.1 - 0.00019 21.1 1.1 0.00049 19.8 0.1 2.1 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK34652.1 - 0.072 13.3 0.7 0.2 11.9 0.7 1.8 1 0 0 1 1 1 0 H2C2 zinc finger RVT_1 PF00078.27 PIK34653.1 - 3.9e-29 101.7 0.0 5.8e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK34653.1 - 9.5e-28 96.2 0.0 3.9e-27 94.2 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34653.1 - 7.9e-24 84.0 0.1 2.4e-23 82.4 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase FAA_hydrolase_N PF09298.11 PIK34653.1 - 0.15 12.3 0.3 7.5 6.8 0.0 2.8 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal UCH PF00443.29 PIK34654.1 - 6.5e-26 91.4 0.2 1.4e-25 90.3 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK34654.1 - 1.9e-14 54.0 2.1 1.9e-14 54.0 2.1 1.8 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PHD PF00628.29 PIK34654.1 - 4.8e-08 32.8 6.5 4.8e-08 32.8 6.5 3.1 3 0 0 3 3 3 1 PHD-finger YyzF PF14116.6 PIK34654.1 - 0.02 14.9 1.2 0.082 12.9 1.2 2.1 1 0 0 1 1 1 0 YyzF-like protein DUF4371 PF14291.6 PIK34655.1 - 1.5e-23 83.6 0.5 2.2e-23 83.2 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 PIK34656.1 - 0.00014 21.6 0.1 0.00033 20.4 0.0 1.6 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Syndecan PF01034.20 PIK34657.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain TMEM132D_C PF15706.5 PIK34657.1 - 0.018 14.8 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Amnionless PF14828.6 PIK34657.1 - 0.03 13.2 0.0 0.033 13.0 0.0 1.1 1 0 0 1 1 1 0 Amnionless Cadherin_C_2 PF16492.5 PIK34657.1 - 0.069 13.9 0.0 0.12 13.2 0.0 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 PIK34657.1 - 0.074 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family m04gp34like PF12216.8 PIK34657.1 - 0.13 11.9 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Immune evasion protein Tmemb_9 PF05434.11 PIK34657.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 TMEM9 CENP-F_leu_zip PF10473.9 PIK34658.1 - 0.033 14.2 1.8 0.033 14.2 1.8 2.1 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.11 PIK34658.1 - 0.49 11.0 4.8 0.5 11.0 2.0 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal CENP-H PF05837.12 PIK34658.1 - 0.66 10.4 5.1 0.3 11.5 0.9 2.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) SRCR PF00530.18 PIK34659.1 - 6e-108 354.0 30.3 9.9e-31 106.2 5.3 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK34659.1 - 2.7e-26 92.0 18.6 7.3e-06 26.4 0.3 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK34659.1 - 9.7e-12 45.4 0.0 0.4 11.2 0.0 4.4 4 0 0 4 4 4 4 Hepsin, SRCR domain TcfC PF16967.5 PIK34659.1 - 0.0095 15.4 0.1 20 4.7 0.0 3.8 4 0 0 4 4 4 2 E-set like domain SRCR PF00530.18 PIK34660.1 - 3.6e-103 338.7 27.5 1.6e-29 102.3 0.6 4.0 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK34660.1 - 4.2e-27 94.6 12.6 2.4e-07 31.2 0.1 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK34660.1 - 8.2e-11 42.4 0.1 0.047 14.2 0.0 4.3 4 0 0 4 4 4 4 Hepsin, SRCR domain TcfC PF16967.5 PIK34660.1 - 0.012 15.1 0.1 15 5.1 0.0 3.2 3 0 0 3 3 3 0 E-set like domain SRCR PF00530.18 PIK34661.1 - 4.8e-86 283.7 23.8 3.8e-31 107.5 5.4 3.2 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Fibrinogen_C PF00147.18 PIK34661.1 - 1.1e-30 107.1 3.9 3.3e-30 105.6 3.9 1.7 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SRCR_2 PF15494.6 PIK34661.1 - 4.5e-20 72.0 11.3 7.3e-06 26.5 0.2 3.6 3 1 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK34661.1 - 4.1e-10 40.1 0.0 0.2 12.2 0.0 3.4 3 0 0 3 3 3 3 Hepsin, SRCR domain TcfC PF16967.5 PIK34661.1 - 0.023 14.2 0.3 6.5 6.3 0.0 3.3 3 0 0 3 3 3 0 E-set like domain SRCR PF00530.18 PIK34662.1 - 2.2e-59 198.2 11.0 1.6e-29 102.4 1.3 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK34662.1 - 2.5e-14 53.6 7.0 6.7e-08 33.0 0.1 3.0 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK34662.1 - 9.9e-05 22.8 0.0 0.71 10.4 0.0 2.4 2 0 0 2 2 2 2 Hepsin, SRCR domain TcfC PF16967.5 PIK34662.1 - 0.19 11.3 0.0 6.8 6.3 0.0 2.6 3 0 0 3 3 3 0 E-set like domain Sigma70_r4_2 PF08281.12 PIK34665.1 - 0.084 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 rve PF00665.26 PIK34668.1 - 2e-18 66.7 0.0 2.6e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK34668.1 - 0.029 14.1 0.0 0.088 12.6 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain AP_endonuc_2 PF01261.24 PIK34668.1 - 0.03 13.8 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel DDE_Tnp_IS240 PF13610.6 PIK34668.1 - 0.065 13.5 0.1 0.093 13.0 0.1 1.2 1 0 0 1 1 1 0 DDE domain 7tm_1 PF00001.21 PIK34669.1 - 9.1e-22 77.6 3.2 1e-21 77.5 3.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK34669.1 - 0.00029 20.2 0.8 0.00032 20.1 0.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw TraG_N PF07916.11 PIK34669.1 - 0.015 14.2 0.2 0.021 13.7 0.2 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Comm PF15957.5 PIK34669.1 - 0.036 14.4 2.6 0.21 11.9 0.1 2.2 1 1 1 2 2 2 0 Commissureless DUF4131 PF13567.6 PIK34669.1 - 0.036 13.7 0.7 0.048 13.3 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Voltage_CLC PF00654.20 PIK34669.1 - 0.039 13.2 1.1 0.044 13.0 1.1 1.1 1 0 0 1 1 1 0 Voltage gated chloride channel DUF1980 PF09323.10 PIK34669.1 - 0.1 12.5 0.3 0.21 11.5 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Keratin PF02422.16 PIK34670.1 - 9.9 5.9 25.5 4.3 7.1 6.5 3.3 1 1 2 3 3 3 0 Keratin adh_short_C2 PF13561.6 PIK34671.1 - 4.7e-22 78.7 0.0 5.6e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK34671.1 - 2.1e-05 24.1 0.0 2.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Dpy19 PF10034.9 PIK34672.1 - 2.8e-56 191.0 9.8 8.3e-24 83.8 0.0 3.0 2 1 1 3 3 3 3 Q-cell neuroblast polarisation DnaJ PF00226.31 PIK34673.1 - 8.4e-17 61.1 0.8 3.3e-16 59.2 0.0 2.5 2 0 0 2 2 2 1 DnaJ domain Sec63 PF02889.16 PIK34673.1 - 5.7e-10 38.8 0.8 0.00047 19.4 0.0 3.0 3 0 0 3 3 3 2 Sec63 Brl domain Nop14 PF04147.12 PIK34673.1 - 0.22 9.7 21.1 0.31 9.2 21.1 1.1 1 0 0 1 1 1 0 Nop14-like family PBP_sp32 PF07222.12 PIK34673.1 - 4.1 6.8 14.1 9 5.7 14.1 1.6 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PsaD PF02531.16 PIK34674.1 - 0.036 13.6 0.1 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 PsaD DSL PF01414.19 PIK34675.1 - 7.7 6.9 92.1 4.4 7.6 15.9 4.8 4 1 1 5 5 5 0 Delta serrate ligand Y_phosphatase PF00102.27 PIK34676.1 - 1.1e-103 345.9 6.1 9.5e-60 202.1 4.0 2.8 2 1 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK34676.1 - 4.3e-09 36.3 0.2 0.00012 21.9 0.1 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK34676.1 - 2.1e-05 24.6 0.0 0.022 14.7 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK34676.1 - 0.00016 21.9 0.2 0.091 12.9 0.0 2.9 3 0 0 3 3 3 2 Inositol hexakisphosphate Y_phosphatase PF00102.27 PIK34677.1 - 1.3e-58 198.4 1.0 1.7e-32 112.9 0.2 2.0 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK34677.1 - 4e-05 23.4 1.0 0.00063 19.6 0.0 2.8 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK34677.1 - 0.0015 18.5 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK34677.1 - 0.0042 17.2 1.7 0.005 17.0 0.1 2.0 3 0 0 3 3 3 1 Inositol hexakisphosphate fn3 PF00041.21 PIK34678.1 - 6.3e-15 55.3 2.5 2.7e-06 27.6 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Y_phosphatase PF00102.27 PIK34678.1 - 2.6e-07 30.5 0.2 5.1e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Syndecan PF01034.20 PIK34678.1 - 0.014 15.3 0.1 0.036 14.0 0.1 1.7 1 0 0 1 1 1 0 Syndecan domain FixQ PF05545.11 PIK34678.1 - 0.037 14.0 0.1 0.083 12.9 0.1 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ EphA2_TM PF14575.6 PIK34678.1 - 0.04 14.8 0.0 0.08 13.8 0.0 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 PIK34678.1 - 0.25 11.6 1.7 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Glycos_transf_2 PF00535.26 PIK34679.1 - 9.9e-23 80.8 0.0 4.3e-22 78.7 0.0 1.9 1 1 1 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 PIK34679.1 - 3.8e-09 36.1 0.0 8.4e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK34679.1 - 2.3e-08 33.9 0.0 2.4e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 PIK34679.1 - 1.4e-06 28.4 0.0 0.0046 16.9 0.0 2.1 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Tox-REase-5 PF15648.6 PIK34679.1 - 0.043 14.3 0.9 0.085 13.4 0.2 1.8 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 5 Tex_YqgF PF16921.5 PIK34680.1 - 1.1e-42 145.4 0.0 2.2e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain Tex_N PF09371.10 PIK34680.1 - 2.1e-21 76.5 1.4 3.6e-21 75.7 1.4 1.3 1 0 0 1 1 1 1 Tex-like protein N-terminal domain HHH_3 PF12836.7 PIK34680.1 - 3.3e-17 62.5 0.1 1e-16 60.9 0.1 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 PIK34680.1 - 4.7e-11 43.4 0.0 2.3e-10 41.2 0.0 2.3 1 0 0 1 1 1 1 HHH domain S1 PF00575.23 PIK34680.1 - 7e-07 29.5 1.1 1.7e-06 28.2 1.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain YqgF PF14639.6 PIK34680.1 - 1.5e-05 24.8 0.0 4.3e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 PIK34680.1 - 0.00015 22.1 0.0 0.00041 20.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 PIK34680.1 - 0.012 16.2 2.9 1.7 9.3 0.2 3.5 2 1 0 2 2 2 0 Helix-hairpin-helix domain HHH PF00633.23 PIK34680.1 - 0.017 15.0 0.1 3.8 7.6 0.0 3.0 3 0 0 3 3 3 0 Helix-hairpin-helix motif MMtag PF10159.9 PIK34681.1 - 2.4e-11 43.8 0.2 2.4e-11 43.8 0.2 3.8 2 1 1 3 3 3 1 Multiple myeloma tumor-associated SAPS PF04499.15 PIK34681.1 - 2.3 6.9 19.7 2.8 6.6 19.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Menin PF05053.13 PIK34681.1 - 7.3 4.8 14.6 8.3 4.6 14.6 1.1 1 0 0 1 1 1 0 Menin Arf PF00025.21 PIK34682.1 - 1.8e-78 262.0 0.0 2e-78 261.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK34682.1 - 5.3e-14 52.5 0.0 7.4e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK34682.1 - 1.2e-13 50.9 0.0 1.4e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK34682.1 - 7.8e-13 48.3 0.0 8.2e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 PIK34682.1 - 8e-13 48.3 0.7 9.6e-09 34.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 PIK34682.1 - 3.3e-11 43.0 0.0 4e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK34682.1 - 4.6e-06 26.7 0.0 6.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK34682.1 - 0.0081 15.5 0.2 0.021 14.1 0.1 1.6 2 0 0 2 2 2 1 6-phosphofructo-2-kinase Csm1_B PF18211.1 PIK34682.1 - 0.063 13.1 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Csm1 subunit domain B AAA_33 PF13671.6 PIK34682.1 - 0.07 13.3 0.3 0.34 11.1 0.3 2.0 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 PIK34683.1 - 5.8e-33 113.8 0.1 6.4e-33 113.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK34683.1 - 0.03 13.8 0.0 0.036 13.5 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK34683.1 - 0.046 13.1 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MeaB PF03308.16 PIK34683.1 - 0.23 10.4 0.2 2.2 7.2 0.2 1.9 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HemY_N PF07219.13 PIK34684.1 - 0.051 13.8 0.9 1.6 8.9 2.3 2.4 2 0 0 2 2 2 0 HemY protein N-terminus Ac76 PF05814.11 PIK34684.1 - 0.053 13.5 0.2 0.053 13.5 0.2 3.2 4 0 0 4 4 4 0 Orf76 (Ac76) Integrase_H2C2 PF17921.1 PIK34685.1 - 1.7e-19 69.7 0.8 1.7e-19 69.7 0.8 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK34685.1 - 0.0088 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK34685.1 - 0.012 15.8 0.5 0.022 15.0 0.1 1.7 2 0 0 2 2 2 0 H2C2 zinc finger Fer4_4 PF12800.7 PIK34685.1 - 3.7 8.3 7.8 1.9 9.2 2.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain RT_RNaseH_2 PF17919.1 PIK34686.1 - 7.9e-36 122.1 0.5 2.4e-35 120.6 0.1 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34686.1 - 2.1e-33 114.7 0.3 5.1e-33 113.5 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34686.1 - 1e-12 48.1 0.0 4e-09 36.3 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK34686.1 - 3.2e-12 46.8 2.8 2.6e-10 40.7 0.1 2.8 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK34686.1 - 4.8e-11 43.1 2.5 6.5e-08 33.1 0.3 2.9 3 0 0 3 3 3 2 Aspartyl protease RVP PF00077.20 PIK34686.1 - 0.0059 16.9 0.0 0.023 15.0 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK34686.1 - 0.0062 16.3 0.1 0.032 14.0 0.1 2.1 1 1 0 1 1 1 1 Aspartyl protease Peptidase_A17 PF05380.13 PIK34686.1 - 0.02 14.9 0.5 0.062 13.3 0.1 1.9 2 0 0 2 2 2 0 Pao retrotransposon peptidase Spuma_A9PTase PF03539.14 PIK34686.1 - 0.065 13.4 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Ran_BP1 PF00638.18 PIK34687.1 - 1.5e-12 47.8 14.9 1.7e-12 47.6 0.3 4.4 3 1 1 4 4 4 2 RanBP1 domain Cornifin PF02389.15 PIK34687.1 - 1.5e-09 38.1 11.8 0.017 15.3 0.4 5.8 2 1 4 6 6 6 4 Cornifin (SPRR) family Fibrinogen_BP PF08017.11 PIK34687.1 - 7.3e-06 24.7 44.9 0.0057 15.2 23.8 2.6 1 1 1 2 2 2 2 Fibrinogen binding protein VID27_PH PF17747.1 PIK34687.1 - 0.0043 17.3 2.7 1.2 9.5 0.1 2.4 2 0 0 2 2 2 2 VID27 PH-like domain Ran_BP1 PF00638.18 PIK34688.1 - 0.013 15.8 2.2 0.024 14.9 2.2 1.5 1 0 0 1 1 1 0 RanBP1 domain D-ser_dehydrat PF14031.6 PIK34688.1 - 0.89 10.2 2.5 2.6 8.8 0.1 2.5 2 1 0 2 2 2 0 Putative serine dehydratase domain Cornifin PF02389.15 PIK34689.1 - 0.0031 17.7 0.3 0.8 9.9 0.0 2.4 1 1 1 2 2 2 2 Cornifin (SPRR) family Ran_BP1 PF00638.18 PIK34690.1 - 5.1e-13 49.3 17.6 1.1e-12 48.3 2.7 3.1 3 0 0 3 3 3 2 RanBP1 domain Cornifin PF02389.15 PIK34690.1 - 0.0019 18.4 0.0 0.33 11.1 0.0 2.2 1 1 1 2 2 2 2 Cornifin (SPRR) family His_Me_b4a2 PF18275.1 PIK34690.1 - 0.0033 17.5 1.8 2.9 8.1 0.2 2.6 2 0 0 2 2 2 2 His-Me finger endonuclease beta4-alpha2 domain CHORD PF04968.12 PIK34690.1 - 0.017 15.9 0.6 11 6.9 0.1 2.5 2 0 0 2 2 2 0 CHORD VID27_PH PF17747.1 PIK34690.1 - 0.081 13.2 4.9 0.59 10.4 1.6 2.6 2 1 0 2 2 2 0 VID27 PH-like domain S-AdoMet_synt_M PF02772.16 PIK34690.1 - 1.1 9.6 10.5 2.3 8.5 0.3 3.1 3 0 0 3 3 3 0 S-adenosylmethionine synthetase, central domain Cornifin PF02389.15 PIK34691.1 - 0.008 16.4 0.0 0.76 10.0 0.0 2.2 1 1 1 2 2 2 2 Cornifin (SPRR) family Y_phosphatase PF00102.27 PIK34693.1 - 3.3e-70 236.3 0.3 4.4e-46 157.3 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK34693.1 - 0.00031 20.5 0.4 0.0011 18.8 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK34693.1 - 0.04 14.0 0.1 0.27 11.3 0.0 2.2 2 1 1 3 3 3 0 Inositol hexakisphosphate NAD_binding_4 PF07993.12 PIK34694.1 - 2.8e-15 56.2 0.0 3.2e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 PIK34694.1 - 0.004 16.6 0.0 0.0043 16.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK34694.1 - 0.0073 15.7 0.0 0.0077 15.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 PIK34694.1 - 0.023 15.1 0.0 0.027 14.9 0.0 1.1 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 PIK34694.1 - 0.025 13.6 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 PIK34694.1 - 0.053 12.6 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 PIK34694.1 - 0.064 13.5 0.0 0.074 13.3 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SpdB PF05122.13 PIK34695.1 - 0.077 13.1 0.3 13 6.0 0.1 2.2 2 0 0 2 2 2 0 Mobile element transfer protein Ion_trans PF00520.31 PIK34696.1 - 1.5e-33 116.1 10.9 2e-33 115.6 10.9 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK34696.1 - 7.6e-13 48.4 0.0 2.2e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK34696.1 - 3.8e-08 33.2 6.8 3.8e-08 33.2 6.8 2.3 2 1 0 2 2 2 1 Ion channel PAS_9 PF13426.7 PIK34696.1 - 0.0032 17.7 0.0 0.0065 16.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain Cupin_2 PF07883.11 PIK34696.1 - 0.0055 16.4 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Cupin domain Ras PF00071.22 PIK34698.1 - 1.4e-22 80.0 0.0 3.3e-12 46.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK34698.1 - 1.5e-07 31.7 0.0 6.3e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK34698.1 - 6.4e-06 26.2 0.0 8.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK34698.1 - 0.0005 19.6 0.0 0.014 14.8 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Arf PF00025.21 PIK34698.1 - 0.0032 17.0 0.0 0.34 10.3 0.0 2.4 2 1 0 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.20 PIK34698.1 - 0.004 16.4 0.0 0.004 16.4 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit DUF4318 PF14201.6 PIK34698.1 - 0.05 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4318) FeoB_N PF02421.18 PIK34698.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 PIK34698.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK34698.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Memo PF01875.17 PIK34699.1 - 4e-57 193.4 1.2 5.8e-49 166.7 0.1 2.0 1 1 1 2 2 2 2 Memo-like protein ECH_1 PF00378.20 PIK34700.1 - 1e-07 31.5 0.2 1.6e-07 30.9 0.2 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK34700.1 - 0.031 14.2 0.1 0.069 13.1 0.0 1.5 2 0 0 2 2 2 0 Peptidase family S49 CBF PF03914.17 PIK34701.1 - 3.6e-08 33.6 0.0 3.6e-08 33.6 0.0 2.4 2 1 0 2 2 2 1 CBF/Mak21 family CBF PF03914.17 PIK34702.1 - 2.8e-35 121.8 1.3 2.2e-34 119.0 0.0 2.1 2 0 0 2 2 2 1 CBF/Mak21 family Adaptin_N PF01602.20 PIK34702.1 - 0.0004 19.1 3.5 0.0017 17.0 0.5 2.1 1 1 0 2 2 2 1 Adaptin N terminal region RTP1_C1 PF10363.9 PIK34702.1 - 0.0033 17.6 0.6 0.14 12.3 0.2 3.4 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 PIK34702.1 - 0.013 15.6 1.4 0.043 13.9 0.5 2.0 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Leu_leader PF08054.11 PIK34702.1 - 0.032 13.8 0.0 0.084 12.5 0.0 1.7 1 0 0 1 1 1 0 Leucine operon leader peptide MetOD2 PF18548.1 PIK34702.1 - 0.059 13.5 0.9 11 6.2 0.1 3.1 3 0 0 3 3 3 0 Metanogen output domain 2 Yippee-Mis18 PF03226.14 PIK34704.1 - 1.2e-12 48.0 0.1 1.5e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 PIK34704.1 - 0.002 18.3 0.1 0.0035 17.6 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of RIG-I SelR PF01641.18 PIK34704.1 - 0.04 14.0 0.1 0.06 13.4 0.1 1.3 1 0 0 1 1 1 0 SelR domain Endonuclease_7 PF02945.15 PIK34704.1 - 0.041 13.8 0.6 0.11 12.5 0.5 1.8 1 1 0 1 1 1 0 Recombination endonuclease VII HNH_5 PF14279.6 PIK34704.1 - 0.043 13.7 0.1 4 7.4 0.0 2.3 2 0 0 2 2 2 0 HNH endonuclease Cation_efflux PF01545.21 PIK34705.1 - 2.7e-22 79.5 10.6 8.9e-22 77.8 10.6 1.7 1 1 0 1 1 1 1 Cation efflux family CcmD PF04995.14 PIK34705.1 - 1.1 9.4 5.5 4.8 7.3 0.2 2.9 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Cation_ATPase_C PF00689.21 PIK34705.1 - 2.5 7.8 10.6 0.36 10.5 5.6 2.1 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus ThiF PF00899.21 PIK34706.1 - 2.6e-34 118.7 0.0 3e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 PIK34706.1 - 0.055 13.5 0.7 0.22 11.6 0.7 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Tyr_Deacylase PF02580.16 PIK34707.1 - 6.2e-27 94.9 0.0 9.3e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Ldh_1_C PF02866.18 PIK34708.1 - 4.6e-38 130.8 0.0 8.2e-38 130.0 0.0 1.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 PIK34708.1 - 7.6e-27 94.1 0.0 2.8e-26 92.3 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_3_C PF01915.22 PIK34708.1 - 0.02 14.9 0.0 0.5 10.3 0.0 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain ZU5 PF00791.20 PIK34709.1 - 1.9e-14 53.8 0.0 4.2e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK34709.1 - 4.1e-07 30.1 0.9 7.4e-07 29.2 0.2 1.8 2 0 0 2 2 2 1 Death domain RVT_1 PF00078.27 PIK34710.1 - 7.7e-11 41.9 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf_C2H2_ZHX PF18387.1 PIK34711.1 - 0.019 14.6 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain Elf1 PF05129.13 PIK34711.1 - 0.037 14.1 1.7 0.088 12.9 1.7 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like OATP PF03137.20 PIK34712.1 - 2.9e-47 161.2 14.0 3.6e-47 160.9 14.0 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_1 PF00050.21 PIK34712.1 - 0.0029 17.6 6.7 0.0095 15.9 6.7 1.9 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain Imm3 PF14425.6 PIK34712.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Immunity protein Imm3 C2 PF00168.30 PIK34713.1 - 1.1e-18 67.4 0.0 2e-17 63.4 0.0 2.2 2 0 0 2 2 2 1 C2 domain C2 PF00168.30 PIK34714.1 - 1.2e-08 35.2 0.0 0.00027 21.2 0.0 2.1 1 1 1 2 2 2 2 C2 domain DUF1347 PF07079.11 PIK34714.1 - 0.19 10.3 0.0 0.24 9.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) Ferlin_C PF16165.5 PIK34715.1 - 8.3e-15 55.0 0.1 9.2e-15 54.9 0.1 1.0 1 0 0 1 1 1 1 Ferlin C-terminus Synaptobrevin PF00957.21 PIK34715.1 - 0.75 9.6 6.2 0.98 9.3 6.2 1.1 1 0 0 1 1 1 0 Synaptobrevin LRR_4 PF12799.7 PIK34716.1 - 0.0016 18.8 16.7 3.2 8.3 0.4 6.4 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) DUF1699 PF08004.11 PIK34716.1 - 0.0056 16.3 0.1 0.69 9.6 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF1699) CARMIL_C PF16000.5 PIK34716.1 - 0.12 12.0 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 CARMIL C-terminus zf-Di19 PF05605.12 PIK34717.1 - 4.4e-10 39.7 0.5 7.7e-09 35.7 0.1 2.3 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 PIK34717.1 - 0.014 15.8 0.1 0.014 15.8 0.1 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK34717.1 - 0.014 16.2 0.6 0.11 13.4 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger CpXC PF14353.6 PIK34717.1 - 0.19 11.7 0.8 0.71 9.9 0.0 2.1 2 0 0 2 2 2 0 CpXC protein zf-H2C2_2 PF13465.6 PIK34717.1 - 0.76 10.3 5.2 6.9 7.3 0.1 3.6 4 0 0 4 4 4 0 Zinc-finger double domain Di19_C PF14571.6 PIK34717.1 - 0.82 10.2 5.2 0.47 11.0 1.9 2.4 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal UnbV_ASPIC PF07593.12 PIK34717.1 - 1.3 9.0 3.3 0.42 10.6 0.2 1.8 2 0 0 2 2 2 0 ASPIC and UnbV SNARE PF05739.19 PIK34718.1 - 2.7e-07 30.5 0.2 5.5e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 PIK34719.1 - 1.7e-25 89.3 14.0 2.2e-24 85.7 6.6 2.1 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.19 PIK34719.1 - 2.5e-19 69.0 1.5 2.5e-19 69.0 1.5 2.1 2 0 0 2 2 1 1 SNARE domain Syntaxin PF00804.25 PIK34719.1 - 3.5e-07 30.1 14.6 3.5e-07 30.1 14.6 2.3 2 1 0 2 2 2 1 Syntaxin Synaptobrevin PF00957.21 PIK34719.1 - 0.0032 17.2 3.3 0.0032 17.2 3.3 2.2 3 0 0 3 3 3 1 Synaptobrevin FliJ PF02050.16 PIK34719.1 - 0.016 15.5 4.4 0.016 15.5 4.4 2.5 2 1 0 2 2 2 0 Flagellar FliJ protein T6SS_VipA PF05591.12 PIK34719.1 - 0.017 15.0 2.7 0.11 12.3 0.1 2.3 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Herpes_US9 PF06072.11 PIK34719.1 - 0.025 14.4 0.3 0.059 13.2 0.3 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF5345 PF17280.2 PIK34719.1 - 0.14 12.1 0.3 0.14 12.1 0.3 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Vac_Fusion PF02346.16 PIK34719.1 - 0.18 11.4 1.9 0.64 9.7 0.0 2.6 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 TMPIT PF07851.13 PIK34719.1 - 0.25 10.6 10.8 0.33 10.2 0.5 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF4366 PF14283.6 PIK34719.1 - 0.41 10.7 4.3 0.13 12.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF2207 PF09972.9 PIK34719.1 - 0.55 8.9 4.7 1.3 7.7 4.7 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4201 PF13870.6 PIK34719.1 - 0.95 9.2 16.3 0.33 10.7 4.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Wzz PF02706.15 PIK34719.1 - 2.8 8.3 8.9 7.7 6.9 0.3 2.8 3 0 0 3 3 3 0 Chain length determinant protein Vma12 PF11712.8 PIK34719.1 - 3.2 7.8 5.8 16 5.6 5.8 2.2 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase MCU PF04678.13 PIK34719.1 - 3.8 7.6 10.3 1 9.4 1.1 2.3 2 1 0 2 2 2 0 Mitochondrial calcium uniporter Exonuc_VII_L PF02601.15 PIK34719.1 - 4.2 6.8 10.7 4.7 6.7 10.1 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit PCRF PF03462.18 PIK34719.1 - 4.7 7.0 10.3 2 8.2 1.8 2.3 2 0 0 2 2 2 0 PCRF domain Fez1 PF06818.15 PIK34719.1 - 7.1 7.0 16.2 15 6.0 9.0 2.1 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.12 PIK34719.1 - 7.2 6.7 8.7 6.6 6.8 2.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 PIK34719.1 - 8.2 4.2 14.8 0.13 10.2 4.4 2.0 1 1 1 2 2 2 0 Prominin RapH_N PF18801.1 PIK34720.1 - 0.92 9.6 2.6 2.2 8.5 2.6 1.5 1 0 0 1 1 1 0 response regulator aspartate phosphatase H, N terminal Nop25 PF09805.9 PIK34720.1 - 1.1 9.8 28.6 0.41 11.1 22.4 2.3 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) FAM60A PF15396.6 PIK34720.1 - 8.1 6.4 12.7 2.5 8.1 3.8 2.3 2 0 0 2 2 2 0 Protein Family FAM60A O-FucT PF10250.9 PIK34721.1 - 2.9e-21 76.6 0.0 3.1e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase NYAP_N PF15439.6 PIK34721.1 - 0.21 10.8 0.1 0.23 10.7 0.1 1.1 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Stealth_CR2 PF11380.8 PIK34722.1 - 0.057 13.6 0.0 0.067 13.4 0.0 1.2 1 0 0 1 1 1 0 Stealth protein CR2, conserved region 2 SH2 PF00017.24 PIK34723.1 - 6.2e-17 61.5 0.1 1.3e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 SH2 domain PNPase_C PF12111.8 PIK34723.1 - 0.017 14.6 0.4 2.4e+02 1.2 0.0 5.3 6 0 0 6 6 6 0 Polyribonucleotide phosphorylase C terminal Plasmo_rep PF12135.8 PIK34723.1 - 1.7 8.3 3.4 6.3e+02 0.0 0.0 5.2 6 0 0 6 6 6 0 Plasmodium repeat family YppG PF14179.6 PIK34723.1 - 9.7 7.0 13.9 27 5.5 0.2 4.5 2 1 4 6 6 6 0 YppG-like protein V-set PF07686.17 PIK34724.1 - 1.3e-08 34.9 0.2 0.044 14.0 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK34724.1 - 6.8e-05 23.4 0.6 1.6 9.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain DUF4397 PF14344.6 PIK34724.1 - 0.007 17.1 1.3 2.2 9.0 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4397) DBP10CT PF08147.12 PIK34724.1 - 0.22 11.8 0.3 1.6 9.1 0.0 2.3 3 0 0 3 3 3 0 DBP10CT (NUC160) domain ubiquitin PF00240.23 PIK34727.1 - 4.2e-14 52.0 0.1 1.6e-13 50.2 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin family LIM PF00412.22 PIK34727.1 - 4.5e-10 39.6 7.0 9.8e-10 38.5 7.0 1.6 1 0 0 1 1 1 1 LIM domain Rad60-SLD PF11976.8 PIK34727.1 - 8.4e-05 22.3 0.0 0.00052 19.8 0.0 2.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Cucumo_2B PF03263.13 PIK34727.1 - 5.2 7.6 18.6 10 6.6 0.0 8.8 6 3 5 11 11 11 0 Cucumovirus protein 2B ubiquitin PF00240.23 PIK34728.1 - 4.9e-235 759.9 59.7 1.4e-28 98.4 0.3 17.2 17 0 0 17 17 17 17 Ubiquitin family Rad60-SLD PF11976.8 PIK34728.1 - 2.8e-85 280.2 53.7 9.7e-13 47.8 0.5 15.2 16 0 0 16 16 16 12 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34728.1 - 8.8e-28 96.6 49.1 0.0014 19.1 0.1 17.1 12 6 5 18 18 18 8 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK34728.1 - 2.6e-22 78.6 20.4 0.17 11.8 0.0 12.8 13 0 0 13 13 13 6 TANK binding kinase 1 ubiquitin-like domain UN_NPL4 PF11543.8 PIK34728.1 - 6.2e-14 52.3 22.0 0.047 14.2 0.0 11.1 12 0 0 12 12 12 4 Nuclear pore localisation protein NPL4 Ubiquitin_5 PF18037.1 PIK34728.1 - 6.1e-10 39.3 26.7 0.004 17.5 0.0 9.2 9 2 2 11 11 10 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34728.1 - 2.9e-08 33.8 12.6 8 6.6 0.0 10.3 8 5 2 11 11 11 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 PIK34728.1 - 5.1e-07 30.3 0.9 10 6.9 0.1 8.2 10 0 0 10 10 9 1 WXG100 protein secretion system (Wss), protein YukD USP7_C2 PF14533.6 PIK34728.1 - 8.7e-06 25.6 16.4 1.6 8.4 0.1 8.5 7 4 1 8 8 8 3 Ubiquitin-specific protease C-terminal Coilin_N PF15862.5 PIK34728.1 - 0.00054 19.8 7.0 0.043 13.6 0.1 4.9 5 0 0 5 5 5 1 Coilin N-terminus TUG-UBL1 PF11470.8 PIK34728.1 - 0.003 17.8 3.1 58 4.0 0.1 6.8 8 0 0 8 8 8 0 TUG ubiquitin-like domain FERM_f0 PF16511.5 PIK34728.1 - 0.0042 17.4 17.4 66 3.9 0.1 11.4 14 1 0 14 14 13 0 N-terminal or F0 domain of Talin-head FERM UBX PF00789.20 PIK34728.1 - 0.033 14.4 0.2 6.1 7.1 0.0 4.9 5 1 1 6 6 6 0 UBX domain SYCP2_SLD PF18584.1 PIK34728.1 - 0.28 11.4 2.9 2.3 8.5 0.3 3.9 3 0 0 3 3 3 0 Synaptonemal complex 2 Spt16M-like domain Ubiquitin_4 PF18036.1 PIK34728.1 - 0.77 9.8 60.4 7.6 6.7 0.2 17.7 15 6 5 20 20 20 0 Ubiquitin-like domain ubiquitin PF00240.23 PIK34729.1 - 2.9e-193 626.0 42.1 4.6e-30 103.2 0.4 8.0 7 1 1 8 8 8 8 Ubiquitin family Rad60-SLD PF11976.8 PIK34729.1 - 4.1e-85 279.6 36.6 1.2e-13 50.7 0.3 8.0 8 0 0 8 8 8 8 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34729.1 - 2.5e-38 130.4 22.2 6.7e-05 23.3 0.0 9.6 8 6 0 8 8 8 8 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK34729.1 - 7.2e-27 93.2 7.8 0.018 14.9 0.0 8.1 7 1 1 8 8 8 7 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK34729.1 - 7.8e-20 71.1 20.8 0.045 14.1 0.0 8.0 4 3 4 8 8 8 6 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34729.1 - 1.3e-16 60.7 10.1 0.076 13.1 0.1 8.7 4 3 4 8 8 8 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 PIK34729.1 - 1.9e-13 50.9 7.3 0.92 10.1 0.0 7.8 1 1 4 8 8 8 4 DUF2407 ubiquitin-like domain RBD PF02196.15 PIK34729.1 - 1.1e-08 35.0 0.4 7.2 6.8 0.0 6.5 7 0 0 7 7 6 2 Raf-like Ras-binding domain DUF2870 PF11069.8 PIK34729.1 - 8e-08 32.6 0.0 19 5.7 0.0 6.7 6 0 0 6 6 6 0 Protein of unknown function (DUF2870) Ubiquitin_4 PF18036.1 PIK34729.1 - 2.9e-07 30.4 31.9 13 5.9 0.0 11.7 12 0 0 12 12 12 0 Ubiquitin-like domain DUF3861 PF12977.7 PIK34729.1 - 1.2e-06 28.6 6.8 14 5.9 0.0 6.7 7 1 1 8 8 7 0 Domain of Unknown Function with PDB structure (DUF3861) Raf1_HTH PF18579.1 PIK34729.1 - 9e-06 25.3 3.1 24 4.7 0.0 7.2 8 0 0 8 8 8 0 Rubisco accumulation factor 1 helix turn helix domain YfmQ PF10787.9 PIK34729.1 - 2.3e-05 24.2 13.1 12 5.7 0.0 7.3 5 2 3 8 8 8 0 Uncharacterised protein from bacillus cereus group RelB PF04221.12 PIK34729.1 - 0.00012 21.9 1.1 21 5.2 0.0 6.5 8 0 0 8 8 8 0 RelB antitoxin CobW_C PF07683.14 PIK34729.1 - 0.0021 18.0 2.0 22 5.1 0.0 5.4 6 0 0 6 6 6 0 Cobalamin synthesis protein cobW C-terminal domain YcgR_2 PF12945.7 PIK34729.1 - 0.017 15.3 13.4 37 4.6 0.1 6.5 7 0 0 7 7 6 0 Flagellar protein YcgR PDGLE PF13190.6 PIK34729.1 - 0.017 15.0 3.9 50 3.9 0.0 5.9 2 2 1 4 4 4 0 PDGLE domain UDP-g_GGTase PF06427.11 PIK34729.1 - 0.024 14.7 5.1 22 5.2 0.1 4.5 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase Pox_A8 PF04745.12 PIK34729.1 - 0.058 12.5 0.8 6.6 5.7 0.0 4.0 3 2 2 5 5 5 0 VITF-3 subunit protein ProRS-C_2 PF09181.10 PIK34729.1 - 0.058 13.5 13.2 14 5.9 0.1 7.3 8 0 0 8 8 8 0 Prolyl-tRNA synthetase, C-terminal HAMP_N3 PF18575.1 PIK34729.1 - 0.38 10.4 11.0 58 3.4 0.0 7.0 8 0 0 8 8 8 0 HAMP N-terminal domain 3 Exog_C PF18026.1 PIK34729.1 - 3 8.0 9.2 7.9 6.6 0.1 4.2 5 0 0 5 5 5 0 Endo/exonuclease (EXOG) C-terminal domain ubiquitin PF00240.23 PIK34730.1 - 1.7e-177 575.5 40.5 5.9e-30 102.8 0.8 7.0 7 0 0 7 7 7 7 Ubiquitin family Rad60-SLD PF11976.8 PIK34730.1 - 1.1e-81 268.7 34.6 2.5e-14 52.9 0.5 7.0 7 0 0 7 7 7 7 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34730.1 - 2e-36 124.3 18.3 0.00013 22.3 0.1 8.7 7 5 0 7 7 7 7 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK34730.1 - 1e-20 73.4 7.1 0.025 14.5 0.0 7.1 6 1 1 7 7 7 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK34730.1 - 2.1e-16 60.1 19.2 0.0057 17.0 0.2 6.5 2 1 5 7 7 7 6 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34730.1 - 3.3e-14 52.9 11.6 0.075 13.1 0.1 7.4 1 1 6 7 7 7 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 PIK34730.1 - 1.3e-08 35.3 6.6 0.67 10.5 0.1 5.5 1 1 2 5 5 5 3 DUF2407 ubiquitin-like domain RBD PF02196.15 PIK34730.1 - 6.6e-08 32.5 0.0 6.5 6.9 0.0 6.7 7 0 0 7 7 7 1 Raf-like Ras-binding domain UN_NPL4 PF11543.8 PIK34730.1 - 1.3e-07 31.9 11.6 1.3 9.6 0.1 7.0 7 0 0 7 7 7 1 Nuclear pore localisation protein NPL4 Raf1_HTH PF18579.1 PIK34730.1 - 1.3e-05 24.8 1.2 22 4.8 0.0 6.3 7 0 0 7 7 7 0 Rubisco accumulation factor 1 helix turn helix domain DUF3861 PF12977.7 PIK34730.1 - 2.1e-05 24.6 6.7 8.3 6.7 0.0 5.9 7 0 0 7 7 7 0 Domain of Unknown Function with PDB structure (DUF3861) APG12 PF04110.13 PIK34730.1 - 6.1e-05 23.3 4.4 58 4.2 0.0 6.8 7 0 0 7 7 7 0 Ubiquitin-like autophagy protein Apg12 DUF2870 PF11069.8 PIK34730.1 - 0.00041 20.7 0.8 72 3.9 0.0 6.1 6 1 0 6 6 6 0 Protein of unknown function (DUF2870) PDGLE PF13190.6 PIK34730.1 - 0.0018 18.1 5.2 34 4.4 0.0 6.3 2 2 4 7 7 7 0 PDGLE domain YfmQ PF10787.9 PIK34730.1 - 0.005 16.6 9.3 13 5.5 0.1 5.8 6 0 0 6 6 6 0 Uncharacterised protein from bacillus cereus group Pullulanase_N2 PF17967.1 PIK34730.1 - 0.0074 17.1 0.0 25 5.8 0.0 4.4 4 0 0 4 4 4 0 Pullulanase N2 domain Closter_coat PF01785.17 PIK34730.1 - 0.0082 15.4 0.0 1e+02 2.1 0.0 4.9 7 0 0 7 7 7 0 Closterovirus coat protein Ubiquitin_4 PF18036.1 PIK34730.1 - 0.011 15.8 38.9 8.5 6.5 0.6 11.6 12 1 0 12 12 12 0 Ubiquitin-like domain HAMP_N3 PF18575.1 PIK34730.1 - 0.045 13.3 6.9 1.2e+02 2.3 0.0 6.5 7 0 0 7 7 7 0 HAMP N-terminal domain 3 UDP-g_GGTase PF06427.11 PIK34730.1 - 0.048 13.8 10.0 4.4 7.5 0.1 5.1 6 0 0 6 6 6 0 UDP-glucose:Glycoprotein Glucosyltransferase ProRS-C_2 PF09181.10 PIK34730.1 - 0.062 13.4 8.1 1.9e+02 2.3 0.0 6.5 7 0 0 7 7 7 0 Prolyl-tRNA synthetase, C-terminal YcgR_2 PF12945.7 PIK34730.1 - 2.7 8.2 15.2 69 3.7 0.0 6.6 7 0 0 7 7 7 0 Flagellar protein YcgR FlgD_ig PF13860.6 PIK34730.1 - 4.5 7.2 15.2 1.4e+02 2.4 0.1 6.4 7 0 0 7 7 7 0 FlgD Ig-like domain DUF4174 PF13778.6 PIK34730.1 - 6.7 7.2 7.7 1.6e+02 2.8 0.1 4.3 3 2 1 4 4 4 0 Domain of unknown function (DUF4174) ubiquitin PF00240.23 PIK34731.1 - 1.5e-63 210.5 4.4 6.2e-32 109.2 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK34731.1 - 2.6e-31 107.3 4.8 1.3e-15 57.0 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34731.1 - 9.7e-12 45.2 1.5 1.8e-05 25.1 0.1 3.4 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK34731.1 - 1.6e-09 38.0 0.3 0.0018 18.6 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34731.1 - 5.7e-08 32.8 0.2 0.0016 18.5 0.1 2.9 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 PIK34731.1 - 5.8e-08 32.6 0.1 0.0024 17.8 0.0 2.2 1 1 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK34731.1 - 1.4e-05 25.1 5.6 2.7 8.1 0.0 4.0 3 1 1 4 4 4 3 Ubiquitin-like domain DUF2407 PF10302.9 PIK34731.1 - 1.6e-05 25.4 0.0 0.19 12.3 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain DUF2870 PF11069.8 PIK34731.1 - 0.01 16.2 0.0 6.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) UN_NPL4 PF11543.8 PIK34731.1 - 0.07 13.6 0.2 16 6.1 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 SMP_C2CD2L PF18696.1 PIK34731.1 - 0.16 11.8 0.4 0.38 10.6 0.1 1.7 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain Plexin_cytopl PF08337.12 PIK34731.1 - 0.29 9.7 5.7 1.8 7.1 0.7 2.9 2 1 1 3 3 3 0 Plexin cytoplasmic RasGAP domain ubiquitin PF00240.23 PIK34732.1 - 3.6e-34 116.3 1.4 3.6e-31 106.7 0.2 2.7 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 PIK34732.1 - 2.2e-14 53.0 3.1 2.8e-14 52.7 0.3 2.3 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK34732.1 - 2.2e-05 24.8 0.1 0.00012 22.5 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK34732.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK34732.1 - 0.0016 18.8 0.1 0.0022 18.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34732.1 - 0.0023 18.0 0.2 0.0077 16.3 0.0 2.0 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 PIK34732.1 - 0.024 14.7 0.7 4.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain ubiquitin PF00240.23 PIK34733.1 - 6.6e-39 131.5 0.5 6.3e-20 70.7 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK34733.1 - 1.6e-14 53.5 1.0 1.1e-06 28.4 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 PIK34733.1 - 0.0012 18.7 0.6 0.14 12.2 0.1 2.1 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 PIK34733.1 - 0.0081 16.6 0.3 0.2 12.1 0.1 2.9 1 1 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK34733.1 - 0.015 15.6 0.1 3 8.3 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK34733.1 - 0.035 14.2 0.0 2.6 8.2 0.0 2.6 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 PIK34733.1 - 0.037 14.6 0.0 2.4 8.8 0.0 2.1 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain FERM_f0 PF16511.5 PIK34733.1 - 0.095 13.0 0.3 14 6.1 0.1 3.0 2 1 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM UCH PF00443.29 PIK34734.1 - 5.6e-41 140.7 0.0 9e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK34734.1 - 4.1e-26 92.3 0.0 6.5e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-RRN7 PF11781.8 PIK34734.1 - 1.5 8.6 4.9 3.4 7.4 2.4 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Anoctamin PF04547.12 PIK34736.1 - 5.5e-126 421.0 17.2 6.6e-126 420.8 17.2 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 PIK34736.1 - 2.4e-11 43.8 0.3 5.9e-11 42.5 0.3 1.6 1 1 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin LapA_dom PF06305.11 PIK34736.1 - 2.4 8.1 4.5 1.4 8.8 0.1 2.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FA_desaturase PF00487.24 PIK34736.1 - 8.1 6.2 9.6 0.42 10.4 0.3 2.8 3 0 0 3 3 3 0 Fatty acid desaturase Patched PF02460.18 PIK34737.1 - 6.1e-116 388.5 5.4 8e-65 219.4 0.2 2.0 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 PIK34737.1 - 6.8e-26 90.9 0.1 6.8e-26 90.9 0.1 2.3 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation AalphaY_MDB PF04611.12 PIK34737.1 - 0.13 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region RVT_2 PF07727.14 PIK34738.1 - 1.6e-29 103.3 0.2 2.2e-29 102.8 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK34739.1 - 4.3e-17 62.4 0.0 1.2e-16 61.0 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DUF4193 PF13834.6 PIK34740.1 - 2.2 8.8 6.2 2.6 8.6 1.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4193) GDI PF00996.18 PIK34741.1 - 6.6e-51 173.2 0.0 3.5e-42 144.4 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 PIK34741.1 - 0.047 13.9 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_C12 PF01088.21 PIK34742.1 - 1.3e-65 221.1 0.0 1.5e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Herpes_IE2_3 PF03361.14 PIK34742.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 Frag1 PF10277.9 PIK34743.1 - 1.1e-08 34.9 6.5 2.2e-08 33.9 6.5 1.5 1 1 0 1 1 1 1 Frag1/DRAM/Sfk1 family CTD_bind PF04818.13 PIK34744.1 - 1.4e-06 29.0 0.2 4.4e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. AIG1 PF04548.16 PIK34746.1 - 1e-29 103.4 0.7 1.5e-29 102.9 0.1 1.5 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 PIK34746.1 - 2.4e-09 37.3 0.0 4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 PIK34746.1 - 1.6e-05 24.1 0.1 2.1e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 PIK34746.1 - 0.00088 19.6 0.1 0.002 18.5 0.0 1.6 2 0 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 PIK34746.1 - 0.0015 18.5 0.1 0.0024 17.8 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 PIK34746.1 - 0.0016 18.6 4.2 0.22 11.6 0.0 2.6 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 PIK34746.1 - 0.0021 17.6 0.1 0.0036 16.8 0.1 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 PIK34746.1 - 0.0088 16.6 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 PIK34746.1 - 0.011 15.3 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_10 PF12846.7 PIK34746.1 - 0.019 13.9 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain DUF815 PF05673.13 PIK34746.1 - 0.019 14.1 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.21 PIK34746.1 - 0.02 14.6 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 Guanylate kinase Ras PF00071.22 PIK34746.1 - 0.022 14.4 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Ras family Septin PF00735.18 PIK34746.1 - 0.039 13.2 0.1 0.066 12.5 0.1 1.4 1 0 0 1 1 1 0 Septin Roc PF08477.13 PIK34746.1 - 0.053 13.8 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Sigma54_activat PF00158.26 PIK34746.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AIG1 PF04548.16 PIK34747.1 - 1e-35 123.0 2.4 5.2e-33 114.2 0.1 3.3 3 0 0 3 3 3 2 AIG1 family MMR_HSR1 PF01926.23 PIK34747.1 - 1.5e-06 28.3 0.0 4.5e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 PIK34747.1 - 0.024 15.1 0.0 0.024 15.1 0.0 3.7 2 1 0 3 3 3 0 ABC transporter RNA_helicase PF00910.22 PIK34747.1 - 0.027 14.9 0.0 0.072 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AIG1 PF04548.16 PIK34748.1 - 2.8e-31 108.5 0.1 4.1e-31 108.0 0.1 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK34748.1 - 4.3e-09 36.4 0.0 6.2e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK34748.1 - 0.00012 22.2 3.5 0.068 13.2 0.0 2.6 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK34748.1 - 0.0006 19.8 0.0 0.00086 19.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK34748.1 - 0.0016 18.9 0.2 0.0024 18.4 0.1 1.4 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 PIK34748.1 - 0.0022 18.4 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 RNA helicase IIGP PF05049.13 PIK34748.1 - 0.0049 16.0 0.0 0.0063 15.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Septin PF00735.18 PIK34748.1 - 0.0099 15.2 0.1 0.02 14.2 0.1 1.6 1 1 0 1 1 1 1 Septin FeoB_N PF02421.18 PIK34748.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_10 PF12846.7 PIK34748.1 - 0.027 13.4 0.1 0.052 12.5 0.1 1.3 1 1 0 1 1 1 0 AAA-like domain T2SSE PF00437.20 PIK34748.1 - 0.034 13.2 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Ras PF00071.22 PIK34748.1 - 0.036 13.7 0.0 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 Ras family AAA_22 PF13401.6 PIK34748.1 - 0.054 13.8 0.5 0.24 11.7 0.2 2.0 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK34748.1 - 0.065 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Guanylate_kin PF00625.21 PIK34748.1 - 0.067 12.9 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase DUF87 PF01935.17 PIK34748.1 - 0.1 12.7 1.1 0.23 11.5 0.5 1.8 1 1 0 1 1 1 0 Helicase HerA, central domain RT_RNaseH_2 PF17919.1 PIK34749.1 - 5.5e-36 122.6 0.0 1e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34749.1 - 1.5e-32 112.0 0.0 3.2e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34749.1 - 2.9e-27 95.6 0.0 4.5e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK34749.1 - 0.029 14.5 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) TTC5_OB PF16669.5 PIK34749.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain RVT_1 PF00078.27 PIK34751.1 - 7.2e-05 22.4 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNA_pol_Rpb2_1 PF04563.15 PIK34752.1 - 1.7e-37 128.9 0.1 1.8e-37 128.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase beta subunit MOZ_SAS PF01853.18 PIK34753.1 - 0.0004 20.1 0.0 0.0054 16.4 0.0 2.2 1 1 1 2 2 2 1 MOZ/SAS family Rap_GAP PF02145.15 PIK34754.1 - 2.4e-57 193.5 0.0 3e-57 193.2 0.0 1.0 1 0 0 1 1 1 1 Rap/ran-GAP PDZ_6 PF17820.1 PIK34755.1 - 0.028 14.3 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 PIK34755.1 - 0.065 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain SPAR_C PF11881.8 PIK34756.1 - 1.2e-13 51.6 3.1 7.9e-12 45.6 3.1 2.6 1 1 0 1 1 1 1 C-terminal domain of SPAR protein Laminin_G_1 PF00054.23 PIK34757.1 - 1.5e-28 99.6 0.0 2.2e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 PIK34757.1 - 2.3e-28 98.1 110.5 3.3e-08 33.7 9.9 8.8 9 0 0 9 9 8 7 EGF-like domain hEGF PF12661.7 PIK34757.1 - 3.6e-28 97.2 83.8 3e-06 27.6 7.7 8.7 8 0 0 8 8 8 7 Human growth factor-like EGF Laminin_G_2 PF02210.24 PIK34757.1 - 7.1e-26 91.2 0.1 1.1e-25 90.6 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain LRR_8 PF13855.6 PIK34757.1 - 1.2e-16 60.2 12.1 4.3e-10 39.2 3.5 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK34757.1 - 1.2e-08 35.0 15.6 0.00064 20.1 0.3 3.4 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) EGF_2 PF07974.13 PIK34757.1 - 1.1e-07 32.1 119.7 0.0014 19.0 10.9 8.6 9 0 0 9 9 9 6 EGF-like domain EGF_CA PF07645.15 PIK34757.1 - 9.4e-05 22.5 27.6 0.00015 21.9 11.3 8.9 5 2 3 8 8 8 3 Calcium-binding EGF domain LRR_5 PF13306.6 PIK34757.1 - 0.0002 21.3 0.1 0.064 13.2 0.0 2.6 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Laminin_EGF PF00053.24 PIK34757.1 - 0.00041 20.4 7.8 0.00041 20.4 7.8 8.6 5 1 4 9 9 8 2 Laminin EGF domain LRRCT PF01463.24 PIK34757.1 - 0.0005 20.4 8.9 0.12 13.0 0.1 4.5 4 0 0 4 4 4 2 Leucine rich repeat C-terminal domain cEGF PF12662.7 PIK34757.1 - 0.00083 19.2 65.1 0.0066 16.4 1.7 8.7 8 1 0 8 8 8 3 Complement Clr-like EGF-like LRRNT PF01462.18 PIK34757.1 - 0.00083 18.9 5.1 0.00083 18.9 5.1 5.4 5 0 0 5 5 5 1 Leucine rich repeat N-terminal domain EGF_3 PF12947.7 PIK34757.1 - 0.0039 17.4 2.6 0.0039 17.4 2.6 8.7 8 0 0 8 8 7 2 EGF domain LRR_9 PF14580.6 PIK34757.1 - 0.018 14.6 1.0 0.17 11.3 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 PIK34757.1 - 0.062 13.9 8.7 4.4 8.2 0.1 5.4 4 0 0 4 4 4 0 Leucine Rich Repeat CUB PF00431.20 PIK34758.1 - 3.5e-12 46.6 0.0 9.5e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 CUB domain Shisa PF13908.6 PIK34758.1 - 0.078 13.2 0.2 0.078 13.2 0.2 2.3 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Mucin PF01456.17 PIK34758.1 - 6.6 6.7 22.8 1.6 8.7 0.1 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Yae1_N PF09811.9 PIK34759.1 - 1.9e-05 24.2 7.6 4.4e-05 23.1 7.6 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Ribosomal_S8e PF01201.22 PIK34760.1 - 9.7e-06 25.8 14.1 9.7e-06 25.8 14.1 2.5 1 1 1 2 2 2 1 Ribosomal protein S8e Ig_3 PF13927.6 PIK34761.1 - 0.00064 20.3 0.2 1.1 9.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK34761.1 - 0.015 15.6 0.1 0.25 11.7 0.1 2.3 2 0 0 2 2 2 0 Immunoglobulin domain SET PF00856.28 PIK34762.1 - 1.2e-12 48.6 0.0 2.2e-12 47.7 0.0 1.5 1 1 0 1 1 1 1 SET domain PDZ PF00595.24 PIK34762.1 - 0.094 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain RVT_1 PF00078.27 PIK34763.1 - 5.2e-27 94.8 0.0 6.5e-27 94.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK34764.1 - 0.0067 16.0 0.3 0.14 11.7 0.3 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK34764.1 - 0.012 15.4 0.5 0.026 14.3 0.1 1.7 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase DUF1409 PF07197.12 PIK34764.1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) Neur_chan_LBD PF02931.23 PIK34765.1 - 1.3e-12 47.7 1.9 1.3e-12 47.6 1.9 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Orn_Arg_deC_N PF02784.16 PIK34766.1 - 1.6e-43 148.9 0.0 1.7e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain zf-C2H2 PF00096.26 PIK34767.1 - 7.7e-16 57.6 25.5 2.6e-05 24.4 3.3 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK34767.1 - 1.5e-14 53.6 22.0 7.7e-08 32.4 0.5 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK34767.1 - 1.4e-09 38.0 22.2 0.00066 20.3 2.0 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 PIK34767.1 - 0.00078 19.7 1.4 0.00078 19.7 1.4 2.3 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding FOXP-CC PF16159.5 PIK34767.1 - 0.0024 18.4 9.8 0.49 11.1 0.4 3.2 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 PIK34767.1 - 0.012 15.9 11.9 1 9.7 1.6 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK34767.1 - 0.012 15.9 6.6 0.025 14.9 6.6 1.6 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf_Hakai PF18408.1 PIK34767.1 - 0.024 14.3 2.4 0.024 14.3 2.4 3.1 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain zf-met PF12874.7 PIK34767.1 - 0.046 14.1 10.7 4 8.0 0.5 4.0 3 2 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 PIK34767.1 - 0.094 12.9 6.7 0.41 10.8 0.3 2.1 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 PIK34767.1 - 0.099 12.7 16.2 0.18 11.9 0.2 3.5 3 1 0 3 3 2 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 PIK34767.1 - 0.38 10.4 8.5 0.62 9.7 0.2 3.0 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain CHORD PF04968.12 PIK34767.1 - 0.79 10.5 11.8 4.4 8.1 1.5 2.4 1 1 1 2 2 2 0 CHORD DEK_C PF08766.11 PIK34768.1 - 1.1e-13 50.8 0.8 3.5e-13 49.3 0.1 2.2 2 0 0 2 2 2 1 DEK C terminal domain SAP PF02037.27 PIK34768.1 - 0.0038 16.9 0.0 0.01 15.6 0.0 1.8 1 0 0 1 1 1 1 SAP domain LAP1C PF05609.12 PIK34768.1 - 1.6 7.8 36.3 0.98 8.4 12.2 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Phage_rep_org_N PF09681.10 PIK34769.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) Cgr1 PF03879.14 PIK34770.1 - 4.7e-15 55.9 32.5 6.1e-15 55.5 32.5 1.1 1 0 0 1 1 1 1 Cgr1 family AAA_23 PF13476.6 PIK34770.1 - 0.31 11.5 13.1 0.39 11.2 13.1 1.3 1 0 0 1 1 1 0 AAA domain HECT PF00632.25 PIK34771.1 - 1.6e-68 231.5 0.1 3.1e-68 230.5 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 PIK34771.1 - 5.5e-06 25.7 0.1 1.7e-05 24.2 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ocular_alb PF02101.15 PIK34772.1 - 1.4e-12 47.3 4.9 1.7e-12 47.0 4.9 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein 7tm_2 PF00002.24 PIK34772.1 - 0.0012 18.2 6.6 0.0018 17.6 6.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF1772 PF08592.11 PIK34772.1 - 0.032 14.5 0.1 0.053 13.8 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Phage_holin_2_4 PF16082.5 PIK34772.1 - 0.13 12.1 1.9 1.1 9.1 1.0 2.1 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF3955 PF13127.6 PIK34772.1 - 3 7.7 9.1 0.29 11.0 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3955) SMG1 PF15785.5 PIK34773.1 - 5.8e-10 38.2 3.3 2.1e-09 36.4 0.7 2.4 2 0 0 2 2 2 2 Serine/threonine-protein kinase smg-1 MMS19_N PF14500.6 PIK34773.1 - 0.18 11.4 2.5 0.35 10.4 0.6 2.2 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II SMG1 PF15785.5 PIK34774.1 - 1.7e-69 234.8 0.3 2.1e-69 234.6 0.3 1.0 1 0 0 1 1 1 1 Serine/threonine-protein kinase smg-1 Sorb PF02208.16 PIK34774.1 - 0.69 9.8 3.4 5.5 6.9 0.4 3.1 3 0 0 3 3 3 0 Sorbin homologous domain SMG1 PF15785.5 PIK34775.1 - 8.4e-14 50.9 0.0 1.2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Serine/threonine-protein kinase smg-1 CAF1-p150_C2 PF15539.6 PIK34776.1 - 0.02 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term HEAT PF02985.22 PIK34776.1 - 0.048 13.9 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 HEAT repeat EST1 PF10374.9 PIK34776.1 - 0.061 14.0 0.0 0.19 12.4 0.0 1.8 1 1 0 1 1 1 0 Telomerase activating protein Est1 ZIP4_domain PF18292.1 PIK34776.1 - 0.079 12.9 1.1 7.5 6.5 0.1 2.3 2 0 0 2 2 2 0 Zinc transporter ZIP4 domain DUF1512 PF07431.12 PIK34776.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) HbrB PF08539.11 PIK34776.1 - 0.11 12.4 0.2 0.18 11.8 0.2 1.3 1 0 0 1 1 1 0 HbrB-like PI3_PI4_kinase PF00454.27 PIK34777.1 - 2.5e-39 135.6 0.0 5.8e-39 134.4 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase CobN-Mg_chel PF02514.16 PIK34777.1 - 0.11 10.3 0.3 0.14 9.8 0.3 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase ZYG-11_interact PF05884.12 PIK34778.1 - 0.18 11.2 0.2 0.2 11.0 0.2 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 FATC PF02260.20 PIK34779.1 - 2.8e-11 43.1 0.4 2.5e-10 40.0 0.1 2.4 2 0 0 2 2 2 1 FATC domain PMC2NT PF08066.12 PIK34779.1 - 6.9 7.4 6.5 6.6 7.5 0.2 3.6 4 1 0 4 4 4 0 PMC2NT (NUC016) domain Gal-3-0_sulfotr PF06990.11 PIK34780.1 - 9.7e-53 179.5 2.5 2.2e-52 178.3 2.5 1.5 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sushi PF00084.20 PIK34781.1 - 7.7e-07 29.6 8.5 0.0012 19.4 0.9 3.2 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) F5_F8_type_C PF00754.25 PIK34781.1 - 0.016 15.4 0.1 0.047 13.8 0.1 1.8 2 0 0 2 2 2 0 F5/8 type C domain Sushi PF00084.20 PIK34782.1 - 2.4e-11 44.1 11.0 2.4e-08 34.5 4.3 3.1 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK34782.1 - 0.0033 18.0 1.2 0.07 13.7 0.1 2.9 3 1 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK34782.1 - 0.036 14.4 0.1 0.036 14.4 0.1 2.7 2 1 1 3 3 3 0 Immunoglobulin domain RVT_1 PF00078.27 PIK34784.1 - 1.6e-06 27.8 0.1 3.7e-06 26.6 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK34785.1 - 4.2e-17 62.3 0.2 1.8e-16 60.3 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK34785.1 - 3.4e-10 40.4 0.0 7.9e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK34785.1 - 9.8e-10 39.0 0.0 2.3e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RT_RNaseH_2 PF17919.1 PIK34785.1 - 1.9e-09 37.4 0.0 6.9e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34785.1 - 4.4e-09 36.2 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 PIK34785.1 - 1.1e-06 28.5 0.0 2.2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 PIK34785.1 - 0.00058 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK34785.1 - 0.00066 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Retrotran_gag_2 PF14223.6 PIK34785.1 - 0.001 18.7 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Retrotrans_gag PF03732.17 PIK34785.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein Peptidase_A2B PF12384.8 PIK34785.1 - 0.094 12.3 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Ty3 transposon peptidase zf-CCHC_2 PF13696.6 PIK34785.1 - 0.98 9.3 7.9 0.24 11.2 3.7 2.2 2 0 0 2 2 2 0 Zinc knuckle GerE PF00196.19 PIK34786.1 - 1e-05 25.0 0.1 3.9e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_23 PF13384.6 PIK34786.1 - 3.5e-05 23.5 0.1 8.9e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 PIK34786.1 - 3.7e-05 23.3 0.0 6.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 rve PF00665.26 PIK34786.1 - 8.2e-05 22.8 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RepA_N PF06970.11 PIK34786.1 - 0.016 15.1 0.1 0.039 13.9 0.1 1.7 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus HTH_38 PF13936.6 PIK34786.1 - 0.031 14.0 0.0 0.076 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Terminase_5 PF06056.12 PIK34786.1 - 0.036 14.0 0.1 0.075 12.9 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_Mga PF08280.11 PIK34786.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Sigma70_r4 PF04545.16 PIK34786.1 - 0.32 10.5 0.0 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 RT_RNaseH_2 PF17919.1 PIK34788.1 - 2.1e-29 101.5 0.0 4.7e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34788.1 - 8.8e-29 100.6 0.0 1.6e-28 99.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK34788.1 - 2.7e-27 95.1 0.0 5.2e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK34788.1 - 1.6e-10 41.0 4.9 6.1e-10 39.1 0.3 3.0 3 0 0 3 3 3 1 Integrase zinc binding domain RVP PF00077.20 PIK34788.1 - 0.0095 16.2 0.0 0.03 14.6 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK34788.1 - 0.016 15.7 0.0 0.048 14.2 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_thumb PF06817.14 PIK34788.1 - 0.051 13.4 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase thumb domain Asp_protease_2 PF13650.6 PIK34788.1 - 0.18 12.5 0.0 0.71 10.6 0.0 2.1 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.26 PIK34789.1 - 1e-12 48.3 0.0 1.2e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK34789.1 - 0.00045 19.9 0.0 0.00078 19.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF4042 PF13251.6 PIK34789.1 - 0.0053 16.5 0.0 0.11 12.2 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4042) Pkinase_Tyr PF07714.17 PIK34790.1 - 8.6e-39 133.4 0.0 1e-38 133.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34790.1 - 5e-12 45.7 0.0 6.3e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain NACHT PF05729.12 PIK34791.1 - 2.1e-08 34.3 0.0 3.3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK34791.1 - 8.2e-05 22.7 0.0 0.00055 20.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain HYR PF02494.16 PIK34792.1 - 6.7e-12 45.6 15.2 0.00015 22.0 2.0 3.1 3 0 0 3 3 3 3 HYR domain SCRL PF06876.12 PIK34792.1 - 0.26 11.5 7.2 5.7 7.2 0.6 3.3 3 0 0 3 3 3 0 Plant self-incompatibility response (SCRL) protein HYR PF02494.16 PIK34793.1 - 9.5e-10 38.7 16.1 0.00041 20.6 2.1 3.1 2 1 1 3 3 3 3 HYR domain SCRL PF06876.12 PIK34793.1 - 0.17 12.1 6.2 26 5.1 0.1 3.3 3 0 0 3 3 3 0 Plant self-incompatibility response (SCRL) protein DDE_Tnp_1_7 PF13843.6 PIK34794.1 - 1e-10 41.5 0.0 1.3e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 RVT_1 PF00078.27 PIK34796.1 - 2.9e-33 115.2 0.0 4.6e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK34797.1 - 0.016 15.1 0.1 0.058 13.2 0.1 2.0 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK34797.1 - 0.021 14.4 1.2 0.34 10.4 0.0 2.7 2 1 1 3 3 3 0 Endonuclease/Exonuclease/phosphatase family DUF1409 PF07197.12 PIK34797.1 - 0.039 13.8 0.0 0.091 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) Spectrin PF00435.21 PIK34798.1 - 1.7e-46 157.0 80.5 5.5e-12 46.1 2.3 8.3 7 1 1 8 8 8 7 Spectrin repeat PilJ PF13675.6 PIK34798.1 - 0.012 15.7 23.2 0.1 12.6 0.5 6.0 4 1 0 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term Tup_N PF08581.10 PIK34798.1 - 0.068 13.5 0.3 0.068 13.5 0.3 8.5 8 1 0 8 8 8 0 Tup N-terminal LOH1CR12 PF10158.9 PIK34798.1 - 2.8 8.0 18.3 0.54 10.3 1.4 5.3 3 1 3 6 6 6 0 Tumour suppressor protein DUF3800 PF12686.7 PIK34798.1 - 7.9 7.1 7.2 2.2e+03 -0.8 7.2 4.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Spectrin PF00435.21 PIK34799.1 - 9e-05 22.9 0.1 0.00016 22.1 0.0 1.4 2 0 0 2 2 2 1 Spectrin repeat Spectrin PF00435.21 PIK34800.1 - 7.2e-06 26.4 2.7 8.4e-06 26.2 2.7 1.1 1 0 0 1 1 1 1 Spectrin repeat Spectrin PF00435.21 PIK34801.1 - 4.4e-12 46.4 3.7 4.8e-12 46.3 3.7 1.0 1 0 0 1 1 1 1 Spectrin repeat DUF1564 PF07600.11 PIK34801.1 - 0.048 13.3 0.1 0.061 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) dCache_1 PF02743.18 PIK34801.1 - 0.05 13.4 0.6 0.058 13.2 0.6 1.0 1 0 0 1 1 1 0 Cache domain EZH2_WD-Binding PF11616.8 PIK34801.1 - 0.051 13.7 0.4 4.3 7.5 0.0 2.4 2 0 0 2 2 2 0 WD repeat binding protein EZH2 Tweety PF04906.13 PIK34801.1 - 0.3 9.7 1.3 0.33 9.6 1.3 1.0 1 0 0 1 1 1 0 Tweety GIT_CC PF16559.5 PIK34802.1 - 0.018 14.9 1.3 0.052 13.4 1.3 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 PIK34802.1 - 0.079 13.6 0.7 0.079 13.6 0.7 2.7 2 2 0 3 3 3 0 Initiation control protein YabA ZapB PF06005.12 PIK34802.1 - 0.11 13.0 10.2 0.5 10.8 0.2 2.9 3 1 0 3 3 3 0 Cell division protein ZapB LRR19-TM PF15176.6 PIK34803.1 - 0.66 10.0 4.7 1.4 8.9 4.7 1.6 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain ubiquitin PF00240.23 PIK34804.1 - 5.5e-16 58.1 0.0 7.6e-16 57.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Tugs PF17840.1 PIK34804.1 - 1.6e-12 47.4 0.2 2.5e-12 46.8 0.2 1.3 1 0 0 1 1 1 1 Tethering Ubl4a to BAGS domain Rad60-SLD PF11976.8 PIK34804.1 - 9.8e-06 25.3 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CCDC142 PF14923.6 PIK34804.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil protein 142 PDZ PF00595.24 PIK34805.1 - 1.3e-15 57.4 0.0 2.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK34805.1 - 4.2e-10 39.3 0.0 7.8e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK34805.1 - 0.00053 20.3 0.0 0.0013 19.0 0.0 1.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 PIK34806.1 - 4.3e-30 103.9 5.0 2.8e-16 59.6 0.2 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK34806.1 - 8.2e-15 54.4 3.0 2.1e-09 37.1 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK34806.1 - 2e-12 47.3 0.8 1.7e-06 28.3 0.1 2.3 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 PIK34806.1 - 0.0024 17.8 0.0 0.34 10.9 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ PF00595.24 PIK34807.1 - 3.9e-11 43.2 0.0 5.1e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK34807.1 - 1.5e-09 37.6 0.0 2.5e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK34807.1 - 1.5e-07 31.7 0.0 2.4e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain rve PF00665.26 PIK34808.1 - 1.4e-19 70.4 0.0 2.3e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK34808.1 - 5.7e-08 32.8 0.1 1.3e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK34808.1 - 0.00098 19.3 0.1 0.0025 18.0 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK34808.1 - 0.0035 17.1 0.0 0.0066 16.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Baculo_LEF-11 PF06385.12 PIK34808.1 - 0.054 14.0 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Baculovirus LEF-11 protein RRM_3 PF08777.11 PIK34809.1 - 0.096 12.7 0.1 0.25 11.4 0.1 1.8 1 0 0 1 1 1 0 RNA binding motif Transposase_21 PF02992.14 PIK34811.1 - 1.5e-10 40.7 0.1 2.6e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Transposase family tnp2 zf-RING_5 PF14634.6 PIK34811.1 - 0.1 12.6 3.4 0.31 11.0 0.9 2.4 2 0 0 2 2 2 0 zinc-RING finger domain A2L_zn_ribbon PF08792.10 PIK34811.1 - 0.56 10.0 3.3 0.48 10.2 0.6 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain RT_RNaseH_2 PF17919.1 PIK34812.1 - 1.1e-26 92.8 0.0 3e-26 91.4 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34812.1 - 1.9e-23 82.7 0.0 4.5e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34812.1 - 1e-19 71.0 0.0 1.9e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK34812.1 - 0.00014 22.5 0.2 0.0099 16.5 0.0 3.3 3 0 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK34812.1 - 0.00081 19.9 0.0 0.5 11.0 0.0 3.0 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease NACHT PF05729.12 PIK34813.1 - 0.099 12.6 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 NACHT domain DED PF01335.21 PIK34814.1 - 3.5e-06 27.2 0.3 0.0057 16.9 0.2 2.3 1 1 1 2 2 2 2 Death effector domain Dict-STAT-coil PF09267.10 PIK34814.1 - 0.095 13.1 0.9 0.18 12.2 0.3 1.8 2 1 0 2 2 2 0 Dictyostelium STAT, coiled coil Acyl-CoA_dh_M PF02770.19 PIK34815.1 - 1.5e-25 89.2 0.0 3.4e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK34815.1 - 3.3e-24 85.7 0.2 8.4e-24 84.4 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 PIK34815.1 - 0.0029 17.8 0.1 0.0047 17.2 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ubiquitin PF00240.23 PIK34816.1 - 3.5e-17 61.9 0.0 8.4e-17 60.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family zf-RING_UBOX PF13445.6 PIK34816.1 - 1.5e-07 31.3 4.0 1.5e-07 31.3 4.0 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK34816.1 - 1.2e-06 28.3 7.3 1.2e-06 28.3 7.3 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Rad60-SLD PF11976.8 PIK34816.1 - 1.4e-06 28.0 0.0 3.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-C3HC4_3 PF13920.6 PIK34816.1 - 3.3e-06 26.9 5.6 3.3e-06 26.9 5.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK34816.1 - 6.8e-06 26.1 5.3 6.8e-06 26.1 5.3 3.1 3 1 0 3 3 3 1 B-box zinc finger zf-RING_5 PF14634.6 PIK34816.1 - 8.7e-05 22.4 7.8 8.7e-05 22.4 7.8 3.2 2 2 1 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK34816.1 - 0.00018 21.3 6.1 0.00018 21.3 6.1 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK34816.1 - 0.00038 20.7 5.2 0.00038 20.7 5.2 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK34816.1 - 0.0014 18.4 6.4 0.0014 18.4 6.4 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) CEBP_ZZ PF16366.5 PIK34816.1 - 0.0034 17.6 10.3 0.18 12.1 3.5 2.5 2 0 0 2 2 2 2 Cytoplasmic polyadenylation element-binding protein ZZ domain Ubiquitin_2 PF14560.6 PIK34816.1 - 0.046 14.2 0.1 0.37 11.3 0.0 2.5 2 1 0 2 2 1 0 Ubiquitin-like domain FYVE_2 PF02318.16 PIK34816.1 - 0.14 12.4 16.5 0.04 14.1 3.9 2.7 1 1 1 2 2 2 0 FYVE-type zinc finger zf-C3HC4_4 PF15227.6 PIK34816.1 - 0.16 12.1 15.9 0.094 12.9 7.5 3.2 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 PIK34816.1 - 0.26 11.5 12.7 1.2 9.3 3.9 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 Zn_Tnp_IS91 PF14319.6 PIK34816.1 - 1 9.4 12.5 1.5 8.9 2.1 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain PID_2 PF14719.6 PIK34817.1 - 1.5e-09 38.0 0.0 2.1e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) HDNR PF15115.6 PIK34818.1 - 1.5e-31 110.0 4.5 1.9e-31 109.6 4.5 1.1 1 0 0 1 1 1 1 Domain of unknown function with conserved HDNR motif CLTH PF10607.9 PIK34819.1 - 1.5e-24 86.6 0.1 2.6e-24 85.8 0.1 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain ARL2_Bind_BART PF11527.8 PIK34819.1 - 0.041 14.0 0.8 0.22 11.6 0.0 2.4 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART RhoGAP PF00620.27 PIK34820.1 - 1.7e-23 83.1 0.1 8.3e-15 54.9 0.0 2.4 1 1 1 2 2 2 2 RhoGAP domain ER-remodelling PF14755.6 PIK34820.1 - 0.016 15.5 5.5 0.017 15.4 3.3 2.1 2 0 0 2 2 2 0 Intracellular membrane remodeller CompInhib_SCIN PF11546.8 PIK34820.1 - 0.096 12.7 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Staphylococcal complement inhibitor SCIN RNase_HII PF01351.18 PIK34821.1 - 4.5e-51 173.5 0.0 6.2e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII Aminotran_1_2 PF00155.21 PIK34822.1 - 5.8e-66 223.1 0.0 6.9e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_28 PF17937.1 PIK34822.1 - 0.061 13.8 0.1 2.6 8.6 0.1 2.8 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain fn3_4 PF16794.5 PIK34822.1 - 0.092 12.7 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Fibronectin-III type domain Myb_DNA-binding PF00249.31 PIK34822.1 - 0.097 12.9 0.0 9.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain RNA_pol_Rpb2_6 PF00562.28 PIK34824.1 - 3.3e-86 289.8 0.4 5e-86 289.2 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 PIK34824.1 - 2.6e-58 196.9 0.0 3.3e-58 196.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 PIK34824.1 - 3.6e-34 117.0 0.8 8.3e-34 115.9 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 PIK34824.1 - 2.1e-19 69.9 0.0 5e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 PIK34824.1 - 2e-18 66.7 0.4 5.7e-18 65.2 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 PIK34824.1 - 8.7e-10 38.8 0.0 2.9e-09 37.1 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 CoA_binding PF02629.19 PIK34825.1 - 1.7e-31 108.8 2.6 1.7e-31 108.8 2.6 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 PIK34825.1 - 4.8e-21 75.2 0.5 1.1e-20 74.0 0.5 1.6 1 1 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 PIK34825.1 - 2.2e-09 37.2 0.1 6.1e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 PIK34825.1 - 2.8e-05 24.6 0.1 8.6e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain HA2 PF04408.23 PIK34826.1 - 3.5e-15 56.2 0.0 3.5e-15 56.2 0.0 2.6 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 PIK34826.1 - 2.8e-12 46.9 0.0 6.8e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 PIK34826.1 - 2e-07 31.3 0.0 5.4e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK34826.1 - 8.6e-07 28.9 0.5 1e-05 25.4 0.5 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK34826.1 - 0.0014 18.9 0.2 0.0047 17.2 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK34826.1 - 0.0034 17.9 1.9 15 6.2 0.0 3.8 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 PIK34826.1 - 0.0084 15.2 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 PIK34826.1 - 0.013 15.1 0.6 0.13 11.7 0.0 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region zf-C2H2_4 PF13894.6 PIK34826.1 - 0.02 15.7 2.9 0.29 12.1 1.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 PIK34826.1 - 0.032 14.5 2.3 1 9.7 0.6 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ATPase PF06745.13 PIK34826.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC Rad17 PF03215.15 PIK34826.1 - 0.067 13.1 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain zf-Sec23_Sec24 PF04810.15 PIK34826.1 - 0.081 13.0 1.2 0.56 10.3 0.2 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger AAA_29 PF13555.6 PIK34826.1 - 0.14 11.9 0.0 0.4 10.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zn-C2H2_12 PF18112.1 PIK34826.1 - 0.17 12.4 4.0 0.5 10.9 0.3 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-MIZ PF02891.20 PIK34826.1 - 0.2 11.4 1.3 2.5 7.9 0.2 2.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf_UBZ PF18439.1 PIK34826.1 - 0.37 10.4 3.7 1.1 8.9 0.5 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Myotub-related PF06602.14 PIK34827.1 - 0.0099 14.8 2.6 0.013 14.4 2.6 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DUF948 PF06103.11 PIK34827.1 - 3.8 7.8 6.7 2.6 8.4 0.1 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ACOX PF01756.19 PIK34828.1 - 5.7e-35 120.5 0.0 9e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA oxidase GCV_H PF01597.19 PIK34828.1 - 3.8e-09 36.5 1.4 99 2.9 0.0 13.4 7 5 11 20 20 20 0 Glycine cleavage H-protein C8 PF08742.11 PIK34828.1 - 1.4e-07 31.8 16.9 8.1 6.9 0.0 13.2 4 4 11 16 16 16 1 C8 domain YlzJ PF14035.6 PIK34828.1 - 0.35 11.1 8.8 54 4.1 0.0 7.8 6 4 5 13 13 13 0 YlzJ-like protein HARE-HTH PF05066.13 PIK34829.1 - 2.1e-08 34.4 0.0 4.5e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain LUD_dom PF02589.15 PIK34829.1 - 0.1 12.3 0.2 0.15 11.8 0.2 1.2 1 0 0 1 1 1 0 LUD domain FYRN PF05964.14 PIK34830.1 - 2e-16 59.5 0.4 4.1e-16 58.6 0.4 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 PIK34830.1 - 1e-14 54.4 0.0 1.8e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 F/Y rich C-terminus MOZ_SAS PF01853.18 PIK34831.1 - 9.9e-82 272.9 4.1 1.2e-81 272.7 4.1 1.1 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 PIK34831.1 - 0.0015 18.9 0.0 0.0024 18.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Cullin PF00888.22 PIK34831.1 - 0.029 13.0 0.1 0.033 12.8 0.1 1.1 1 0 0 1 1 1 0 Cullin family Trypsin PF00089.26 PIK34832.1 - 1.9e-61 207.7 0.0 2.8e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK34832.1 - 0.00019 21.8 0.0 0.00035 20.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CENP-F_leu_zip PF10473.9 PIK34832.1 - 0.00046 20.2 0.7 0.00075 19.5 0.7 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 PIK34832.1 - 0.016 15.3 2.0 0.03 14.4 2.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding BST2 PF16716.5 PIK34832.1 - 0.018 15.6 2.2 0.032 14.8 2.2 1.3 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 YscO PF07321.12 PIK34832.1 - 0.035 14.1 0.2 0.049 13.6 0.2 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO Paralemmin PF03285.15 PIK34832.1 - 0.049 13.2 1.1 0.071 12.7 1.1 1.1 1 0 0 1 1 1 0 Paralemmin DUF4094 PF13334.6 PIK34832.1 - 0.058 13.8 0.2 0.46 10.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) zf-C4H2 PF10146.9 PIK34832.1 - 0.066 13.5 0.6 0.11 12.9 0.6 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein FlxA PF14282.6 PIK34832.1 - 0.069 13.1 5.8 0.12 12.4 5.8 1.3 1 0 0 1 1 1 0 FlxA-like protein Spc24 PF08286.11 PIK34832.1 - 0.081 13.2 1.3 0.17 12.2 1.3 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF1664 PF07889.12 PIK34832.1 - 0.096 12.7 0.4 0.16 12.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TRAF_BIRC3_bd PF16673.5 PIK34832.1 - 0.15 11.9 0.4 0.25 11.2 0.4 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DMPK_coil PF08826.10 PIK34832.1 - 0.17 12.0 3.1 0.28 11.3 3.1 1.3 1 0 0 1 1 1 0 DMPK coiled coil domain like Tropomyosin_1 PF12718.7 PIK34832.1 - 0.21 11.8 2.7 0.15 12.2 1.3 1.4 2 0 0 2 2 2 0 Tropomyosin like KRTAP7 PF15034.6 PIK34833.1 - 0.16 13.0 2.4 0.9 10.5 2.4 2.2 1 1 0 1 1 1 0 KRTAP type 7 family LRR_8 PF13855.6 PIK34834.1 - 1.8e-12 46.8 19.9 1.2e-06 28.2 2.4 3.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK34834.1 - 1.3e-11 44.6 8.9 0.00038 20.8 2.6 3.9 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK34834.1 - 5.1e-06 26.1 0.9 7.3 6.9 0.1 5.6 4 1 1 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 PIK34834.1 - 0.014 15.8 5.1 46 5.1 1.2 5.4 3 3 0 3 3 3 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK34834.1 - 0.017 14.6 1.6 0.34 10.4 0.3 2.0 1 1 1 2 2 2 0 Leucine-rich repeat FAM194 PF14977.6 PIK34835.1 - 2.1e-30 105.6 0.0 4.2e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 FAM194 protein Dimer_Tnp_hAT PF05699.14 PIK34835.1 - 0.00072 19.3 0.2 0.002 17.9 0.2 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sina PF03145.16 PIK34836.1 - 4.3e-47 160.7 2.4 4.5e-47 160.6 2.4 1.0 1 0 0 1 1 1 1 Seven in absentia protein family zf_C2H2_6 PF18450.1 PIK34836.1 - 0.013 15.2 0.4 0.013 15.2 0.4 1.6 2 0 0 2 2 2 0 Zinc Finger domain zf-TRAF PF02176.18 PIK34836.1 - 0.093 13.4 5.8 0.17 12.6 0.1 2.3 1 1 1 2 2 2 0 TRAF-type zinc finger DUF1565 PF07602.11 PIK34838.1 - 0.12 11.6 0.1 0.15 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) PID PF00640.23 PIK34839.1 - 8.1e-28 97.2 0.0 1.2e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 PIK34839.1 - 6.1e-17 61.7 0.9 1e-13 51.4 0.1 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 PIK34839.1 - 2.4e-06 27.3 0.0 0.00012 21.8 0.0 2.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK34839.1 - 0.0085 16.4 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain CHCH PF06747.13 PIK34840.1 - 6.5e-07 29.3 2.1 6.5e-07 29.3 2.1 2.9 3 0 0 3 3 3 2 CHCH domain CX9C PF16860.5 PIK34840.1 - 0.0009 19.2 9.6 0.027 14.5 1.5 2.4 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 PIK34840.1 - 0.34 11.0 11.1 0.68 10.0 1.4 2.7 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 PIK34840.1 - 0.66 10.3 11.5 1.2 9.5 1.4 2.8 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 PIK34840.1 - 3.6 7.4 9.8 0.26 11.0 2.2 2.2 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) ATP-gua_Ptrans PF00217.19 PIK34842.1 - 1.7e-60 204.1 0.0 2.3e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 PIK34842.1 - 6.5e-08 32.9 0.3 1.2e-07 32.0 0.3 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Acetyltransf_CG PF14542.6 PIK34844.1 - 1.1e-21 76.8 0.0 1.3e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 PIK34844.1 - 0.06 12.8 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Ldh_1_C PF02866.18 PIK34844.1 - 0.089 12.7 0.0 0.093 12.7 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain zinc_ribbon_10 PF10058.9 PIK34845.1 - 8.1e-14 51.1 0.0 1.7e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Herpes_LMP1 PF05297.11 PIK34845.1 - 0.13 11.4 3.9 0.22 10.7 3.9 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RVT_1 PF00078.27 PIK34846.1 - 4.8e-12 45.9 0.1 8.3e-12 45.1 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) OATP PF03137.20 PIK34847.1 - 5.6e-33 114.0 6.3 7.6e-33 113.6 6.3 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK34847.1 - 5.4e-08 32.8 8.9 1.1e-07 31.9 8.9 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK34847.1 - 0.0016 18.4 6.2 0.0016 18.4 6.2 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.7 PIK34847.1 - 0.0019 17.1 0.3 0.0019 17.1 0.3 1.4 2 0 0 2 2 2 1 MFS_1 like family MFS_1 PF07690.16 PIK34847.1 - 0.0071 15.3 4.1 0.011 14.7 4.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Nuc_H_symport PF03825.16 PIK34847.1 - 0.054 12.5 4.1 0.12 11.3 3.7 1.8 1 1 1 2 2 2 0 Nucleoside H+ symporter DUF1677 PF07911.13 PIK34848.1 - 0.025 15.0 1.4 0.21 12.0 1.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1677) RT_RNaseH_2 PF17919.1 PIK34849.1 - 4.9e-34 116.4 0.0 1.1e-33 115.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34849.1 - 2.3e-28 98.6 0.0 3.6e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase C1q PF00386.21 PIK34850.1 - 0.16 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 C1q domain GIDA PF01134.22 PIK34851.1 - 2.7e-151 504.1 0.0 3.5e-151 503.7 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 PIK34851.1 - 1.1e-55 189.1 0.0 1.6e-55 188.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 PIK34851.1 - 2.1e-06 27.4 0.2 4.4e-06 26.3 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK34851.1 - 8.9e-06 25.0 1.4 9.3e-05 21.7 0.8 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK34851.1 - 0.00021 20.6 1.1 0.00069 18.9 1.0 2.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK34851.1 - 0.00031 19.6 0.6 0.022 13.5 0.2 2.4 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 PIK34851.1 - 0.0026 18.3 0.1 0.0067 17.0 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 PIK34851.1 - 0.0091 15.3 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 PIK34851.1 - 0.11 12.7 0.5 0.3 11.3 0.5 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK34851.1 - 0.16 11.2 0.0 0.38 10.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 PIK34851.1 - 0.29 10.1 3.9 1.5 7.8 3.9 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein RRM_1 PF00076.22 PIK34853.1 - 3.1e-09 36.5 0.0 4.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DSPc PF00782.20 PIK34854.1 - 6.1e-23 81.1 0.0 7e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 PIK34854.1 - 0.00078 19.7 0.0 0.002 18.4 0.0 1.6 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 PIK34854.1 - 0.046 13.3 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FMO-like PF00743.19 PIK34855.1 - 2.2e-135 452.1 0.0 2.7e-135 451.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK34855.1 - 6.8e-16 58.4 0.2 1.7e-13 50.5 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK34855.1 - 2.1e-09 37.1 0.0 8.5e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK34855.1 - 4.2e-07 29.4 0.5 3.8e-05 23.0 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK34855.1 - 2e-05 24.8 0.0 4.9e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK34855.1 - 0.0027 17.4 0.1 2.4 7.6 0.2 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK34855.1 - 0.012 15.6 0.0 0.044 13.8 0.0 2.0 2 1 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 PIK34855.1 - 0.029 13.7 0.2 0.047 13.0 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 PIK34855.1 - 0.073 12.3 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 PIK34855.1 - 0.12 12.9 0.6 19 5.9 0.1 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK34855.1 - 0.22 10.5 0.3 0.65 9.0 0.5 1.7 1 1 1 2 2 2 0 FAD binding domain Sep15_SelM PF08806.11 PIK34856.1 - 3.4e-20 72.0 0.3 3.9e-20 71.8 0.3 1.0 1 0 0 1 1 1 1 Sep15/SelM redox domain Rubrerythrin PF02915.17 PIK34856.1 - 0.011 16.1 0.1 0.013 15.9 0.1 1.1 1 0 0 1 1 1 0 Rubrerythrin Kelch_1 PF01344.25 PIK34857.1 - 5.4e-71 234.0 8.9 1.8e-16 59.4 0.1 6.5 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 PIK34857.1 - 7e-37 124.5 4.8 1.9e-09 37.5 0.0 6.3 3 2 3 6 6 6 6 Kelch motif Kelch_2 PF07646.15 PIK34857.1 - 2.9e-29 99.9 2.8 5.8e-07 29.2 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 PIK34857.1 - 6.4e-25 86.9 0.7 2e-05 24.7 0.0 5.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK34857.1 - 2e-23 82.1 0.8 3.3e-05 23.8 0.0 6.1 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK34857.1 - 4.3e-12 45.7 0.3 0.15 12.1 0.0 4.9 5 0 0 5 5 5 4 Kelch motif DUF1668 PF07893.13 PIK34857.1 - 0.02 14.3 0.3 2.6 7.3 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1668) BILBO1_N PF18281.1 PIK34857.1 - 0.51 10.8 4.5 12 6.3 0.0 3.8 4 1 1 5 5 5 0 BILBO1 N-terminal domain RT_RNaseH_2 PF17919.1 PIK34859.1 - 4.3e-29 100.5 0.0 7.6e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34859.1 - 8.3e-28 96.8 0.0 1.4e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK34859.1 - 4.4e-14 52.5 0.0 8.2e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK34859.1 - 7.6e-12 45.2 1.2 7.6e-12 45.2 1.2 2.1 2 0 0 2 2 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK34859.1 - 5.4e-06 26.2 16.2 0.0013 18.8 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-H2C2 PF09337.10 PIK34859.1 - 0.00037 20.6 0.3 0.0013 18.9 0.1 2.1 2 0 0 2 2 1 1 H2C2 zinc finger zf-CCHC_6 PF15288.6 PIK34859.1 - 0.005 16.6 9.0 0.2 11.5 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK34859.1 - 0.023 14.7 12.8 0.4 10.7 1.1 3.6 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK34859.1 - 0.042 13.7 0.2 0.042 13.7 0.2 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK34859.1 - 0.043 13.5 0.8 0.043 13.5 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK34859.1 - 0.17 11.6 11.1 9.4 6.1 0.4 3.6 2 1 1 3 3 3 0 Zinc knuckle BCNT PF07572.12 PIK34859.1 - 0.17 11.9 0.1 0.34 11.0 0.1 1.4 1 0 0 1 1 1 0 Bucentaur or craniofacial development V_ATPase_I PF01496.19 PIK34861.1 - 4.6 5.0 13.6 5.8 4.7 13.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-CCHC PF00098.23 PIK34864.1 - 0.01 15.9 1.4 0.01 15.9 1.4 2.7 2 0 0 2 2 2 0 Zinc knuckle zinc_ribbon_2 PF13240.6 PIK34864.1 - 0.36 10.6 3.8 62 3.5 3.8 2.9 1 1 0 1 1 1 0 zinc-ribbon domain ArgoL2 PF16488.5 PIK34867.1 - 0.17 12.2 0.3 28 5.2 0.0 2.4 2 0 0 2 2 2 0 Argonaute linker 2 domain Integrase_H2C2 PF17921.1 PIK34868.1 - 0.00018 21.5 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain UIM PF02809.20 PIK34868.1 - 0.14 12.2 1.7 0.33 11.0 1.7 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif HYR PF02494.16 PIK34869.1 - 2.5e-48 162.3 5.7 1.5e-23 82.9 0.2 2.5 2 0 0 2 2 2 2 HYR domain Y_phosphatase PF00102.27 PIK34869.1 - 2e-28 99.6 1.6 3e-28 99.0 1.6 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Toxin_29 PF08116.11 PIK34870.1 - 0.098 12.7 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 PhTx neurotoxin family DUF2095 PF09868.9 PIK34870.1 - 0.17 11.8 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) LRR_8 PF13855.6 PIK34871.1 - 2.5e-62 206.5 46.0 8.5e-11 41.5 1.2 9.4 3 3 7 10 10 10 10 Leucine rich repeat LRR_5 PF13306.6 PIK34871.1 - 1.1e-31 109.5 29.2 2e-10 40.7 2.8 4.1 1 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK34871.1 - 7.6e-22 77.0 54.3 4.4e-06 26.9 0.7 11.0 4 3 8 13 13 13 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK34871.1 - 2.6e-13 49.9 18.9 3.7e-05 23.3 0.2 5.8 1 1 4 6 6 6 4 Leucine-rich repeat LRR_1 PF00560.33 PIK34871.1 - 1.3e-07 31.2 37.1 4.2 8.3 0.0 12.3 14 1 1 15 15 15 3 Leucine Rich Repeat LRRNT PF01462.18 PIK34871.1 - 5.6e-06 25.9 4.1 0.00021 20.9 0.6 4.1 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain DUF1647 PF07801.11 PIK34871.1 - 0.037 13.8 1.4 0.45 10.3 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1647) LRR_6 PF13516.6 PIK34871.1 - 0.091 12.9 32.1 6.3 7.1 0.1 9.7 10 0 0 10 10 10 0 Leucine Rich repeat LRR_11 PF18831.1 PIK34871.1 - 0.11 12.1 0.7 14 5.4 0.0 3.2 2 0 0 2 2 2 0 Leucine-rich repeat RII_binding_1 PF10522.9 PIK34871.1 - 0.23 11.8 0.4 19 5.8 0.0 3.6 3 0 0 3 3 3 0 RII binding domain TRP PF06011.12 PIK34872.1 - 5.1e-05 22.2 16.4 0.00031 19.6 0.2 2.6 2 1 1 3 3 3 2 Transient receptor potential (TRP) ion channel DUF2681 PF10883.8 PIK34872.1 - 0.012 16.0 4.5 0.25 11.8 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Ephrin_rec_like PF07699.13 PIK34872.1 - 0.014 15.2 5.2 0.014 15.2 5.2 6.0 2 2 4 6 6 6 0 Putative ephrin-receptor like NCD3G PF07562.14 PIK34872.1 - 0.066 13.2 28.2 0.43 10.6 2.6 4.5 4 0 0 4 4 4 0 Nine Cysteines Domain of family 3 GPCR PIG-P PF08510.12 PIK34872.1 - 2.1 8.3 7.1 14 5.7 0.8 3.2 2 1 0 2 2 2 0 PIG-P DUF4381 PF14316.6 PIK34872.1 - 5.8 7.1 6.7 1.8 8.8 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) NACHT PF05729.12 PIK34873.1 - 2.8e-13 50.1 0.0 4.1e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK34873.1 - 0.00017 21.2 0.0 0.00053 19.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 PIK34873.1 - 0.06 13.1 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 PIK34873.1 - 0.15 12.5 0.0 24 5.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain Guanylate_cyc PF00211.20 PIK34875.1 - 3.5e-64 215.8 0.0 4.1e-64 215.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain WD40 PF00400.32 PIK34876.1 - 6.2e-09 36.4 4.0 0.0016 19.3 0.0 4.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK34876.1 - 8.3e-05 22.8 0.2 17 5.8 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Syntaxin_2 PF14523.6 PIK34877.1 - 5.4e-21 74.9 6.3 5.4e-21 74.9 6.3 2.2 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 PIK34877.1 - 8.6e-15 54.5 0.3 8.6e-15 54.5 0.3 4.0 4 1 0 4 4 4 1 SNARE domain Syntaxin PF00804.25 PIK34877.1 - 0.00026 20.7 16.2 0.0034 17.1 2.9 2.4 2 0 0 2 2 2 2 Syntaxin MCPsignal PF00015.21 PIK34877.1 - 0.00099 19.0 12.7 0.15 11.9 1.8 3.1 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain T2SSF PF00482.23 PIK34877.1 - 0.0012 18.8 3.9 0.026 14.5 1.1 2.3 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F Phage_holin_3_6 PF07332.11 PIK34877.1 - 0.0096 15.9 0.3 0.019 15.0 0.3 1.5 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Spectrin PF00435.21 PIK34877.1 - 0.014 15.9 1.3 0.014 15.9 1.3 2.8 2 2 0 2 2 2 0 Spectrin repeat Prominin PF05478.11 PIK34877.1 - 0.024 12.6 11.0 0.094 10.7 4.4 2.1 1 1 0 2 2 2 0 Prominin SlyX PF04102.12 PIK34877.1 - 0.048 14.3 10.0 0.19 12.4 0.1 3.7 3 2 2 5 5 4 0 SlyX DNA_repr_REX1B PF14966.6 PIK34877.1 - 0.059 14.0 0.1 0.059 14.0 0.1 3.2 2 2 0 3 3 3 0 DNA repair REX1-B Laminin_II PF06009.12 PIK34877.1 - 0.093 12.7 13.5 1.5 8.8 2.2 3.1 2 1 0 3 3 3 0 Laminin Domain II Baculo_PEP_C PF04513.12 PIK34877.1 - 0.23 11.5 6.8 0.53 10.3 1.4 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MRP-S27 PF10037.9 PIK34877.1 - 0.28 10.0 10.4 0.076 11.9 7.2 1.5 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 NPV_P10 PF05531.12 PIK34877.1 - 0.29 11.6 7.6 4.9 7.7 3.3 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.11 PIK34877.1 - 0.41 10.7 12.1 0.3 11.2 0.9 3.2 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3130 PF11328.8 PIK34877.1 - 0.5 10.6 5.2 3.6 7.9 0.2 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF3130 Spore_III_AB PF09548.10 PIK34877.1 - 1.3 9.1 10.8 1.3 9.1 0.3 2.9 1 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) ISG65-75 PF11727.8 PIK34877.1 - 2.4 7.3 9.7 2.1 7.5 1.1 2.3 2 1 0 2 2 2 0 Invariant surface glycoprotein DUF1676 PF07898.13 PIK34877.1 - 6.3 6.8 8.8 42 4.1 8.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) TMPIT PF07851.13 PIK34877.1 - 6.6 5.9 10.9 8.9 5.5 3.1 2.4 1 1 2 3 3 3 0 TMPIT-like protein DUF4572 PF15139.6 PIK34878.1 - 1.5e-78 263.2 4.5 1.7e-78 263.1 4.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4572) RecQ5 PF06959.11 PIK34878.1 - 0.015 15.3 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 RecQ helicase protein-like 5 (RecQ5) IlvC PF01450.19 PIK34878.1 - 0.17 12.2 0.2 0.28 11.5 0.2 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain SR-25 PF10500.9 PIK34879.1 - 2e-08 34.1 10.1 2.4e-08 33.9 10.1 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein NAM-associated PF14303.6 PIK34879.1 - 0.031 15.0 7.9 0.041 14.6 7.9 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain PRP38_assoc PF12871.7 PIK34879.1 - 0.063 13.9 13.4 0.078 13.6 13.4 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF4614 PF15391.6 PIK34879.1 - 0.18 11.8 10.9 0.23 11.4 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Bul1_C PF04426.12 PIK34879.1 - 0.4 10.1 3.3 0.48 9.8 3.3 1.1 1 0 0 1 1 1 0 Bul1 C terminus RAP1 PF07218.11 PIK34879.1 - 0.45 8.7 5.7 0.45 8.7 5.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Raftlin PF15250.6 PIK34879.1 - 0.53 9.0 6.8 0.62 8.8 6.8 1.0 1 0 0 1 1 1 0 Raftlin Neur_chan_memb PF02932.16 PIK34879.1 - 0.63 10.1 6.3 0.69 9.9 6.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Herpes_pp85 PF04637.12 PIK34879.1 - 0.72 8.2 5.4 0.81 8.0 5.4 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Macoilin PF09726.9 PIK34879.1 - 1 7.8 9.0 1.1 7.7 9.0 1.1 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 PIK34879.1 - 1.2 7.3 9.7 1.4 7.1 9.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Plasmodium_Vir PF05795.11 PIK34879.1 - 1.6 8.1 7.2 1.7 8.0 7.2 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CCDC106 PF15794.5 PIK34879.1 - 1.7 8.3 12.7 2.3 7.9 12.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Hid1 PF12722.7 PIK34879.1 - 1.7 6.7 10.5 2 6.4 10.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RSRP PF17069.5 PIK34879.1 - 2.4 7.7 15.5 2.9 7.4 15.5 1.1 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Apt1 PF10351.9 PIK34879.1 - 2.6 6.8 13.0 3.1 6.6 13.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Herpes_capsid PF06112.11 PIK34879.1 - 3.9 7.5 14.5 5.4 7.0 14.5 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein NPR3 PF03666.13 PIK34879.1 - 4.3 6.0 8.8 4.4 6.0 8.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 PIK34879.1 - 5 5.8 12.2 5.8 5.6 12.2 1.0 1 0 0 1 1 1 0 Presenilin Ribosomal_L35Ae PF01247.18 PIK34884.1 - 5.5e-41 138.7 1.3 6.3e-41 138.5 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 PIK34884.1 - 0.011 15.9 0.1 2.8 8.2 0.1 2.2 2 0 0 2 2 2 0 RimM N-terminal domain IQ PF00612.27 PIK34885.1 - 4.8e-05 22.8 0.5 0.00015 21.3 0.5 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif PhosphMutase PF10143.9 PIK34885.1 - 0.91 9.4 5.9 0.68 9.8 3.2 2.1 2 0 0 2 2 2 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApoO PF09769.9 PIK34885.1 - 2.3 8.2 6.2 7.3 6.6 0.6 2.7 1 1 1 2 2 2 0 Apolipoprotein O Peptidase_M15_3 PF08291.11 PIK34885.1 - 3.3 7.8 7.0 3.7 7.7 0.6 3.2 3 0 0 3 3 3 0 Peptidase M15 Glyco_transf_41 PF13844.6 PIK34885.1 - 5.1 5.4 11.8 2.2 6.6 9.2 1.6 1 1 1 2 2 2 0 Glycosyl transferase family 41 AKNA PF12443.8 PIK34885.1 - 6.4 7.5 15.6 1.3 9.7 5.9 3.4 2 2 2 4 4 4 0 AT-hook-containing transcription factor MFS_1_like PF12832.7 PIK34886.1 - 7.1e-71 239.1 11.9 8.5e-71 238.8 11.9 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK34886.1 - 7.8e-17 61.2 26.4 1.3e-16 60.5 26.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 PIK34886.1 - 1.3e-09 37.3 13.1 1.5e-05 24.0 5.4 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter Nuc_H_symport PF03825.16 PIK34886.1 - 2.2e-07 30.2 10.9 1.7e-06 27.3 5.9 2.1 2 0 0 2 2 2 2 Nucleoside H+ symporter MFS_3 PF05977.13 PIK34886.1 - 0.1 11.0 1.6 6 5.1 0.0 2.8 3 0 0 3 3 3 0 Transmembrane secretion effector EXS PF03124.14 PIK34886.1 - 0.18 11.1 9.1 0.061 12.6 1.5 2.2 1 1 1 2 2 2 0 EXS family DUF4131 PF13567.6 PIK34886.1 - 0.76 9.4 4.0 11 5.7 0.3 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) 7tm_1 PF00001.21 PIK34887.1 - 6.2e-08 32.3 1.8 8.3e-08 31.9 1.8 1.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK34887.1 - 0.0077 15.6 0.4 0.0077 15.6 0.4 1.8 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK34888.1 - 9.6e-31 107.1 9.2 9.6e-31 107.1 9.2 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK34888.1 - 1.5e-10 41.2 8.1 1.5e-10 41.2 8.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx GPR_Gpa2_C PF11970.8 PIK34888.1 - 0.066 13.3 1.6 0.21 11.7 0.4 2.5 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term RRM_1 PF00076.22 PIK34889.1 - 1.2e-13 50.7 0.0 1.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 PIK34889.1 - 0.18 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 RL domain ORC6 PF05460.13 PIK34890.1 - 0.41 9.9 4.5 0.51 9.6 4.5 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Y_phosphatase PF00102.27 PIK34892.1 - 1e-47 162.7 0.1 1.5e-41 142.5 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Peptidase_A3 PF02160.15 PIK34893.1 - 0.0064 16.0 0.4 0.018 14.5 0.1 1.8 2 0 0 2 2 2 1 Cauliflower mosaic virus peptidase (A3) Gal_mutarotas_2 PF13802.6 PIK34895.1 - 4.6e-26 90.9 0.1 7.9e-26 90.2 0.1 1.4 1 0 0 1 1 1 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 PIK34895.1 - 1.8e-24 86.8 0.8 2.5e-24 86.3 0.1 1.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 31 Glyco_hydro_31 PF01055.26 PIK34896.1 - 4.6e-49 167.8 1.0 2e-48 165.7 1.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 PIK34896.1 - 1.6e-07 31.5 0.2 3.5e-07 30.4 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) ADP_PFK_GK PF04587.15 PIK34897.1 - 6.6e-103 344.5 0.0 7e-103 344.4 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region ADP_PFK_GK PF04587.15 PIK34898.1 - 1.5e-19 69.9 0.0 3.8e-19 68.6 0.0 1.5 2 0 0 2 2 2 1 ADP-specific Phosphofructokinase/Glucokinase conserved region DUF5340 PF17275.2 PIK34898.1 - 0.14 12.3 0.0 0.86 9.8 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5340) ERCC4 PF02732.15 PIK34899.1 - 5.4e-26 91.7 0.1 5.3e-24 85.2 0.0 2.9 3 0 0 3 3 3 1 ERCC4 domain KH_8 PF17903.1 PIK34899.1 - 0.094 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Krr1 KH1 domain Macoilin PF09726.9 PIK34899.1 - 0.19 10.3 4.5 0.26 9.8 4.5 1.2 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 PIK34899.1 - 4.3 7.1 10.8 6.6 6.5 10.8 1.3 1 0 0 1 1 1 0 SPX domain HTH_45 PF14947.6 PIK34900.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1495 PF07381.11 PIK34900.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) DUF4364 PF14277.6 PIK34900.1 - 0.028 14.2 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HTH_27 PF13463.6 PIK34900.1 - 0.11 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain DEAD PF00270.29 PIK34901.1 - 2.1e-24 86.3 0.0 2.9e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 PIK34901.1 - 0.0016 17.9 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 PIK34901.1 - 0.065 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK34902.1 - 2.1e-30 105.3 0.0 3.5e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HECT PF00632.25 PIK34903.1 - 3e-83 279.8 0.0 5e-83 279.1 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 PIK34904.1 - 6.5e-19 68.3 0.2 9.1e-19 67.8 0.2 1.2 1 0 0 1 1 1 1 WWE domain Arm PF00514.23 PIK34906.1 - 0.00022 21.2 0.2 0.01 15.8 0.0 2.8 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat NTP_transf_8 PF12281.8 PIK34906.1 - 0.0045 17.0 0.0 0.007 16.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyltransferase HEAT_2 PF13646.6 PIK34906.1 - 0.023 15.1 0.0 0.18 12.2 0.0 2.2 1 1 1 2 2 2 0 HEAT repeats FANCI_S1 PF14675.6 PIK34906.1 - 0.036 13.6 1.8 0.31 10.6 0.3 2.0 1 1 1 2 2 2 0 FANCI solenoid 1 MMS19_N PF14500.6 PIK34906.1 - 0.062 12.9 1.0 0.093 12.3 0.8 1.4 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II PGA2 PF07543.12 PIK34907.1 - 0.13 12.2 4.0 0.56 10.2 0.4 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF4551 PF15087.6 PIK34907.1 - 0.82 8.4 16.9 0.96 8.2 16.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ndc1_Nup PF09531.10 PIK34907.1 - 2.5 6.7 11.7 3.1 6.4 11.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 7tm_2 PF00002.24 PIK34908.1 - 1.6e-19 70.2 10.5 4.1e-10 39.4 3.9 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK34908.1 - 2.8e-06 27.7 6.6 2.8e-06 27.7 6.6 2.0 2 1 0 2 2 2 1 GPCR proteolysis site, GPS, motif Coa1 PF08695.10 PIK34908.1 - 0.85 9.4 5.7 1.6 8.5 0.1 2.9 2 1 1 3 3 3 0 Cytochrome oxidase complex assembly protein 1 Cytochrom_B_C PF00032.17 PIK34908.1 - 4.9 7.5 5.4 1.5 9.2 1.6 2.1 2 2 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD DUF4149 PF13664.6 PIK34908.1 - 7.6 6.9 8.9 0.78 10.1 0.2 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4149) SH3_1 PF00018.28 PIK34910.1 - 8.5e-24 82.9 11.3 2e-12 46.5 0.2 3.3 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 PIK34910.1 - 2.7e-22 78.3 6.5 1.2e-12 47.5 0.2 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 PIK34910.1 - 1.6e-15 56.5 0.9 3.3e-05 23.5 0.0 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_3 PF08239.11 PIK34910.1 - 5.9e-08 32.9 12.7 0.019 15.2 0.2 3.4 3 0 0 3 3 3 3 Bacterial SH3 domain DUF1604 PF07713.13 PIK34910.1 - 0.22 11.3 1.3 4.1 7.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1604) Rtf2 PF04641.12 PIK34911.1 - 1.5e-05 24.5 6.0 1.8e-05 24.3 6.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-U1 PF06220.12 PIK34911.1 - 0.0011 18.7 1.4 0.0017 18.1 1.4 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.8 PIK34911.1 - 0.066 13.5 6.8 0.25 11.7 6.8 2.0 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK34911.1 - 0.12 12.8 4.9 0.38 11.2 4.7 1.9 1 1 0 1 1 1 0 Zinc-finger of C2H2 type DUF913 PF06025.12 PIK34911.1 - 1.3 8.0 8.0 1.5 7.7 8.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Borrelia_P83 PF05262.11 PIK34911.1 - 1.9 6.8 19.2 2.2 6.7 19.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein CSG2 PF16965.5 PIK34911.1 - 7.1 5.5 5.3 11 4.8 5.3 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Hid1 PF12722.7 PIK34911.1 - 7.1 4.6 12.6 7.9 4.5 12.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein zf-C2H2_2 PF12756.7 PIK34912.1 - 1.9e-05 24.9 2.5 1.9e-05 24.9 2.5 3.6 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 PIK34912.1 - 0.0019 18.4 4.3 0.0019 18.4 4.3 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK34912.1 - 0.0047 17.3 2.8 0.0047 17.3 2.8 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-U1 PF06220.12 PIK34912.1 - 0.0073 16.1 0.8 0.0073 16.1 0.8 3.2 3 0 0 3 3 3 1 U1 zinc finger zf-C2H2_6 PF13912.6 PIK34912.1 - 0.012 15.6 1.1 0.012 15.6 1.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger Methyltrn_RNA_3 PF02598.17 PIK34914.1 - 0.077 12.5 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methyltransferase RT_RNaseH_2 PF17919.1 PIK34915.1 - 6.2e-38 128.9 0.0 1e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK34915.1 - 2.4e-36 124.2 0.0 6e-36 122.9 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK34915.1 - 3.4e-07 30.3 1.2 7.7e-07 29.1 0.2 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain PIGA PF08288.12 PIK34916.1 - 2.4e-33 114.6 0.2 3.6e-33 114.0 0.2 1.2 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 PIK34916.1 - 1.6e-14 54.3 0.1 2e-14 53.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 PIK34916.1 - 3.6e-06 27.5 0.0 4.7e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 PIK34916.1 - 0.017 14.8 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 PIK34917.1 - 2e-18 66.5 0.0 2.6e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK34917.1 - 9.2e-15 55.3 0.0 1.2e-14 54.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 PIK34917.1 - 0.0037 17.6 0.0 0.0058 17.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 SNARE_assoc PF09335.11 PIK34918.1 - 1.4e-18 67.5 7.8 3.9e-18 66.1 6.5 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein Peptidase_M1 PF01433.20 PIK34919.1 - 4.9e-77 258.4 1.3 1.8e-66 223.9 0.4 2.3 2 0 0 2 2 2 2 Peptidase family M1 domain ERAP1_C PF11838.8 PIK34919.1 - 8.2e-63 212.8 0.1 1e-61 209.3 0.1 2.2 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 PIK34919.1 - 2e-48 165.1 0.0 3.9e-44 151.1 0.0 3.0 2 1 1 3 3 3 2 Peptidase M1 N-terminal domain Gal-3-0_sulfotr PF06990.11 PIK34920.1 - 7.9e-24 84.3 0.4 8.8e-24 84.1 0.4 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase RVT_1 PF00078.27 PIK34921.1 - 4.3e-43 147.4 0.2 8.1e-43 146.5 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TSP_1 PF00090.19 PIK34922.1 - 8.6e-05 22.7 8.3 8.6e-05 22.7 8.3 3.3 3 0 0 3 3 3 2 Thrombospondin type 1 domain RXLR_WY PF18634.1 PIK34923.1 - 0.00022 21.1 17.2 16 5.5 0.1 8.8 10 0 0 10 10 10 3 RXLR phytopathogen effector protein WY-domain DUF5615 PF18480.1 PIK34923.1 - 0.0072 16.1 0.0 11 5.9 0.0 3.5 2 1 1 3 3 3 2 Domain of unknown function (DUF5615) S10_plectin PF03501.15 PIK34923.1 - 2 8.5 5.7 21 5.3 0.1 4.4 4 1 1 5 5 5 0 Plectin/S10 domain TSP_1 PF00090.19 PIK34924.1 - 2.8e-10 40.2 19.7 3.9e-09 36.6 1.7 3.2 3 0 0 3 3 3 2 Thrombospondin type 1 domain TSP_1 PF00090.19 PIK34925.1 - 5.4e-20 71.4 67.1 0.0001 22.4 6.7 7.8 7 2 0 7 7 7 6 Thrombospondin type 1 domain V-set PF07686.17 PIK34925.1 - 0.052 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Cadherin PF00028.17 PIK34926.1 - 0.00012 22.4 0.0 0.0002 21.7 0.0 1.4 1 1 0 1 1 1 1 Cadherin domain Peptidase_C5 PF00770.18 PIK34926.1 - 0.097 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Adenovirus endoprotease Cadherin PF00028.17 PIK34927.1 - 1.1e-106 349.5 39.2 8.7e-15 54.9 0.0 11.4 8 3 3 11 11 11 11 Cadherin domain Cadherin_2 PF08266.12 PIK34927.1 - 3.4e-15 55.7 0.4 0.39 10.6 0.0 7.5 8 1 0 8 8 8 5 Cadherin-like Cadherin_3 PF16184.5 PIK34927.1 - 0.00033 20.6 13.9 0.99 9.4 0.0 6.8 5 2 2 7 7 7 2 Cadherin-like Minor_capsid_3 PF12691.7 PIK34927.1 - 0.16 12.3 5.4 0.93 9.9 0.5 3.3 2 1 1 3 3 3 0 Minor capsid protein from bacteriophage Bax1-I PF01027.20 PIK34928.1 - 3.1e-35 121.9 11.3 4.4e-35 121.4 11.3 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ABC2_membrane_2 PF12679.7 PIK34928.1 - 0.4 9.9 5.6 0.75 9.0 4.7 2.0 2 1 0 2 2 2 0 ABC-2 family transporter protein 3HCDH_N PF02737.18 PIK34929.1 - 2.5e-60 203.5 1.2 3.2e-60 203.1 1.2 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 PIK34929.1 - 9.9e-08 31.5 2.9 1.7e-07 30.8 2.9 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 PIK34929.1 - 1e-06 29.2 0.4 2.9e-06 27.8 0.4 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK34929.1 - 1.8e-06 27.4 0.8 2.5e-06 26.9 0.8 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 PIK34929.1 - 2.4e-06 27.8 2.2 1.2e-05 25.6 2.2 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.6 PIK34929.1 - 3.2e-05 24.3 0.6 5.9e-05 23.4 0.6 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 PIK34929.1 - 0.00011 22.5 0.8 0.00021 21.5 0.8 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 PIK34929.1 - 0.00017 22.1 3.6 0.0018 18.8 3.6 2.2 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 PIK34929.1 - 0.00018 21.5 0.8 0.00054 20.0 0.8 1.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 PIK34929.1 - 0.00032 20.0 0.4 0.0005 19.4 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 PIK34929.1 - 0.00056 19.5 3.4 0.0017 17.9 3.4 1.7 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 PIK34929.1 - 0.00074 19.2 1.7 0.0016 18.1 1.8 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK34929.1 - 0.00078 19.6 0.2 0.0044 17.2 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK34929.1 - 0.0024 17.2 1.3 0.0034 16.7 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.6 PIK34929.1 - 0.0084 16.6 0.0 0.013 16.1 0.0 1.3 1 0 0 1 1 1 1 XdhC Rossmann domain GIDA PF01134.22 PIK34929.1 - 0.0098 15.0 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A TrkA_N PF02254.18 PIK34929.1 - 0.013 15.8 0.5 0.032 14.5 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.14 PIK34929.1 - 0.026 13.2 1.5 0.032 13.0 1.0 1.4 1 1 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 PIK34929.1 - 0.033 13.3 0.1 0.036 13.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DFP PF04127.15 PIK34929.1 - 0.036 13.9 2.9 0.11 12.3 2.9 1.9 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein FTCD_C PF04961.12 PIK34929.1 - 0.093 12.5 1.6 0.13 12.0 1.6 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Shikimate_DH PF01488.20 PIK34929.1 - 0.14 12.2 3.2 0.42 10.7 0.5 2.2 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase OTCace PF00185.24 PIK34929.1 - 0.15 12.2 0.8 1.3 9.1 0.8 2.2 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain FAD_oxidored PF12831.7 PIK34929.1 - 0.3 10.4 4.1 0.15 11.4 2.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH PF00725.22 PIK34930.1 - 3.3e-34 117.4 0.0 3.9e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Ig_2 PF13895.6 PIK34931.1 - 2.8e-07 30.8 1.4 0.00079 19.7 0.0 4.0 3 1 0 3 3 3 1 Immunoglobulin domain Shisa PF13908.6 PIK34931.1 - 0.017 15.4 0.2 0.038 14.2 0.1 1.5 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator ig PF00047.25 PIK34931.1 - 1.2 9.4 5.1 17 5.7 0.0 3.9 3 1 0 3 3 3 0 Immunoglobulin domain Sulfotransfer_1 PF00685.27 PIK34932.1 - 3.1e-09 36.7 0.1 3.6e-09 36.5 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain ADH_zinc_N PF00107.26 PIK34934.1 - 3.7e-19 69.0 0.0 5.2e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK34934.1 - 1.2e-05 26.4 0.0 1.6e-05 25.9 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK34934.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.5 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus ANF_receptor PF01094.28 PIK34935.1 - 9.7e-07 28.2 0.6 1.7e-05 24.1 0.1 2.1 1 1 1 2 2 2 2 Receptor family ligand binding region Ammonium_transp PF00909.21 PIK34936.1 - 9e-69 232.1 20.5 1.1e-68 231.7 20.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1691 PF07950.11 PIK34936.1 - 0.14 12.9 0.2 0.14 12.9 0.2 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF1691) ZYG-11_interact PF05884.12 PIK34936.1 - 1.8 7.9 8.8 6.6 6.1 3.9 2.3 2 1 0 2 2 2 0 Interactor of ZYG-11 LSM PF01423.22 PIK34938.1 - 0.00016 21.3 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 LSM domain DUF4515 PF14988.6 PIK34939.1 - 4.1e-19 69.2 22.1 4.1e-19 69.2 22.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4515) DUF4618 PF15397.6 PIK34939.1 - 0.0006 19.3 25.5 0.00095 18.7 25.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) DUF3584 PF12128.8 PIK34939.1 - 0.02 12.5 21.7 0.024 12.2 21.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 PIK34939.1 - 0.14 12.3 36.7 5.6 7.0 22.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ZnuA PF01297.17 PIK34939.1 - 0.33 10.3 3.5 0.49 9.8 3.5 1.4 1 1 0 1 1 1 0 Zinc-uptake complex component A periplasmic Bacillus_HBL PF05791.11 PIK34939.1 - 0.37 10.6 11.8 7.6 6.3 0.1 2.6 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3112 PF11309.8 PIK34939.1 - 0.47 9.9 1.4 0.67 9.4 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) DAPDH_C PF16654.5 PIK34939.1 - 1.1 9.1 6.5 1.6 8.5 2.5 2.1 1 1 1 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain PI_PP_I PF18363.1 PIK34939.1 - 1.1 9.5 5.9 3.8 7.8 1.3 2.3 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain APG6_N PF17675.1 PIK34939.1 - 1.1 9.8 38.2 0.8 10.2 13.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 PIK34939.1 - 1.4 9.9 29.6 3.5 8.6 13.2 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Fez1 PF06818.15 PIK34939.1 - 2.2 8.7 28.2 5.2 7.5 14.1 2.1 1 1 1 2 2 2 0 Fez1 TPR_MLP1_2 PF07926.12 PIK34939.1 - 2.6 8.1 31.0 0.63 10.1 5.7 2.4 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIVA PF05103.13 PIK34939.1 - 2.7 8.1 23.1 4.2 7.5 10.4 2.4 1 1 1 2 2 2 0 DivIVA protein Spc7 PF08317.11 PIK34939.1 - 2.9 6.7 31.0 0.43 9.4 7.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 PIK34939.1 - 5 6.5 31.1 21 4.4 31.0 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 Fib_alpha PF08702.10 PIK34939.1 - 8 6.6 20.0 1.1 9.4 14.6 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AP_endonuc_2 PF01261.24 PIK34940.1 - 9.5e-32 110.1 0.0 1.2e-31 109.8 0.0 1.0 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Phage_Gp17 PF17549.2 PIK34940.1 - 0.069 13.2 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Gene Product 17 Snf7 PF03357.21 PIK34941.1 - 2e-29 102.4 5.8 2.4e-29 102.1 5.8 1.0 1 0 0 1 1 1 1 Snf7 Rad33 PF08730.10 PIK34941.1 - 0.017 15.1 0.9 0.22 11.5 0.0 2.6 2 1 1 3 3 3 0 Rad33 TGF_beta PF00019.20 PIK34942.1 - 3.1e-28 98.8 0.1 5.2e-28 98.1 0.1 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 PIK34942.1 - 1.7e-10 41.1 0.0 2.8e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide Ribosomal_L15e PF00827.17 PIK34943.1 - 3.9e-55 186.6 4.2 1.6e-32 112.8 0.0 2.2 1 1 1 2 2 2 2 Ribosomal L15 MFS_5 PF05631.14 PIK34944.1 - 1.9e-89 300.1 12.8 2.4e-89 299.7 12.8 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 PIK34944.1 - 2.9e-14 52.8 37.1 2.6e-09 36.5 17.4 3.0 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK34944.1 - 2.4e-06 26.7 2.2 2.4e-06 26.7 2.2 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Phosducin PF02114.16 PIK34945.1 - 5.5e-28 97.6 0.0 6e-28 97.5 0.0 1.0 1 0 0 1 1 1 1 Phosducin Cellulase-like PF12876.7 PIK34946.1 - 0.0036 16.7 0.1 0.0065 15.9 0.1 1.3 1 0 0 1 1 1 1 Sugar-binding cellulase-like COesterase PF00135.28 PIK34947.1 - 1.5e-19 70.3 0.2 1.6e-19 70.2 0.2 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK34948.1 - 3e-94 316.7 0.0 3.8e-94 316.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK34948.1 - 5.4e-05 23.1 0.1 0.00036 20.4 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold RVT_1 PF00078.27 PIK34949.1 - 3.4e-10 39.8 0.1 5.1e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Muted PF14942.6 PIK34949.1 - 0.16 12.3 3.1 0.31 11.4 3.1 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF727 PF05303.12 PIK34950.1 - 8.1e-11 41.9 0.0 1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) COesterase PF00135.28 PIK34951.1 - 1.2e-22 80.5 0.0 1.4e-22 80.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family LRR_8 PF13855.6 PIK34952.1 - 0.0017 18.1 3.1 0.0062 16.3 3.1 1.9 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 PIK34952.1 - 0.017 15.6 3.2 0.71 10.6 0.2 2.8 2 0 0 2 2 2 0 Leucine Rich Repeat MatE PF01554.18 PIK34952.1 - 0.036 13.7 0.1 0.05 13.2 0.1 1.1 1 0 0 1 1 1 0 MatE NICE-3 PF07406.11 PIK34952.1 - 0.12 12.4 0.7 1.7 8.6 0.2 2.1 2 0 0 2 2 2 0 NICE-3 protein LRR_4 PF12799.7 PIK34952.1 - 0.14 12.6 4.4 0.95 10.0 4.4 2.2 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) PGF-CTERM PF18204.1 PIK34952.1 - 0.28 11.2 2.2 0.43 10.6 2.2 1.3 1 0 0 1 1 1 0 PGF-CTERM motif LRR_6 PF13516.6 PIK34952.1 - 0.68 10.1 4.2 4.4 7.6 0.7 2.8 3 0 0 3 3 3 0 Leucine Rich repeat PHD PF00628.29 PIK34954.1 - 8.9e-06 25.5 8.6 2.2e-05 24.2 8.6 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK34954.1 - 0.036 13.6 1.9 0.068 12.7 1.9 1.5 1 0 0 1 1 1 0 PHD-finger Ig_3 PF13927.6 PIK34955.1 - 0.041 14.5 0.2 3.7 8.2 0.1 3.2 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK34955.1 - 0.24 11.8 4.7 17 5.8 0.2 3.5 2 2 1 3 3 3 0 Immunoglobulin domain SNF2_N PF00176.23 PIK34956.1 - 1.7e-61 207.9 0.5 2.7e-35 121.7 0.1 3.0 3 0 0 3 3 3 2 SNF2 family N-terminal domain DUF3535 PF12054.8 PIK34956.1 - 6.4e-53 180.6 0.0 4.1e-42 144.9 0.0 3.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3535) HEAT PF02985.22 PIK34956.1 - 7.9e-11 41.3 10.4 1.4 9.4 0.0 9.4 8 1 1 9 9 9 3 HEAT repeat Helicase_C PF00271.31 PIK34956.1 - 6.4e-05 23.3 0.0 0.00024 21.4 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Vac14_Fab1_bd PF12755.7 PIK34956.1 - 0.00038 21.0 0.0 0.023 15.3 0.0 3.0 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region DEAD PF00270.29 PIK34956.1 - 0.0029 17.4 0.0 0.0093 15.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HEAT_2 PF13646.6 PIK34956.1 - 0.045 14.2 4.2 14 6.2 0.1 5.7 7 0 0 7 7 7 0 HEAT repeats CLASP_N PF12348.8 PIK34956.1 - 0.16 11.5 0.8 17 4.9 0.0 3.8 4 0 0 4 4 4 0 CLASP N terminal HEAT_EZ PF13513.6 PIK34956.1 - 0.2 12.2 11.3 11 6.6 0.1 7.1 9 0 0 9 9 9 0 HEAT-like repeat eIF-3c_N PF05470.12 PIK34958.1 - 0.016 13.6 11.8 0.019 13.3 11.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Spt5_N PF11942.8 PIK34958.1 - 0.07 14.1 13.3 0.12 13.4 13.3 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 PIK34958.1 - 2.6 6.2 13.7 2.7 6.2 13.7 1.0 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 PIK34958.1 - 5.1 7.4 11.4 8 6.7 11.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DNA_pol_phi PF04931.13 PIK34958.1 - 5.5 5.0 11.8 6.1 4.8 11.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pkinase_Tyr PF07714.17 PIK34959.1 - 1.9e-20 73.3 0.0 2.1e-20 73.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34959.1 - 2.4e-07 30.4 0.0 2.8e-07 30.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Comm PF15957.5 PIK34960.1 - 0.22 11.9 1.3 0.64 10.4 1.1 1.7 1 1 1 2 2 2 0 Commissureless ABC_tran PF00005.27 PIK34961.1 - 2.7e-35 121.9 0.0 5.6e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK34961.1 - 2.7e-18 66.6 1.5 4e-18 66.0 1.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK34961.1 - 4.1e-06 26.4 2.2 0.00032 20.2 0.0 2.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK34961.1 - 5.7e-05 23.0 0.2 0.00031 20.6 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 PIK34961.1 - 0.00026 20.7 0.2 0.002 17.8 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 PIK34961.1 - 0.013 15.7 0.1 0.028 14.5 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 PIK34961.1 - 0.019 15.4 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 PIK34961.1 - 0.02 14.1 0.1 0.19 10.9 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit CbiA PF01656.23 PIK34961.1 - 0.02 14.9 0.0 6 6.9 0.0 2.4 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_21 PF13304.6 PIK34961.1 - 0.037 13.8 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 PIK34961.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK34961.1 - 0.069 12.7 0.0 0.39 10.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 PIK34961.1 - 0.09 12.0 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 PIK34961.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK34961.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 PIK34961.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 PIK34962.1 - 1.6e-08 34.6 0.6 1.9e-08 34.3 0.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region PTS_EIIC PF02378.18 PIK34962.1 - 0.054 12.5 1.8 0.64 9.0 1.9 2.0 1 1 1 2 2 2 0 Phosphotransferase system, EIIC Ebola_NP PF05505.12 PIK34962.1 - 0.11 10.8 0.1 1.4 7.1 0.0 2.0 1 1 0 2 2 2 0 Ebola nucleoprotein SASRP1 PF15160.6 PIK34963.1 - 2.4e-14 53.6 0.3 3.1e-14 53.2 0.3 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated serine-rich protein 1 DUF2870 PF11069.8 PIK34964.1 - 2.3e-42 143.3 1.7 2.3e-42 143.3 1.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) RVT_1 PF00078.27 PIK34965.1 - 0.00031 20.3 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cupin_8 PF13621.6 PIK34967.1 - 6.1e-44 150.6 0.1 8.1e-44 150.2 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK34967.1 - 3.5e-06 26.7 0.0 6.4e-06 25.8 0.0 1.4 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 PIK34967.1 - 3.8e-05 24.1 0.1 7.8e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Coa1 PF08695.10 PIK34968.1 - 2e-15 56.5 0.0 2.6e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Trypsin PF00089.26 PIK34969.1 - 2.3e-53 181.3 0.1 3.2e-53 180.8 0.1 1.2 1 0 0 1 1 1 1 Trypsin Lectin_C PF00059.21 PIK34969.1 - 3.5e-10 40.6 0.0 6.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Ldl_recept_a PF00057.18 PIK34969.1 - 0.00044 20.4 1.7 0.0014 18.8 1.7 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 PIK34969.1 - 0.04 13.7 0.1 0.075 12.8 0.1 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like RdRP_3 PF00998.23 PIK34971.1 - 0.066 11.9 0.2 0.09 11.5 0.2 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase HTH_16 PF12645.7 PIK34973.1 - 0.09 12.8 0.3 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Zein-binding PF04576.15 PIK34973.1 - 0.38 11.1 5.8 0.086 13.1 1.9 1.8 2 0 0 2 2 2 0 Zein-binding DUF3454 PF11936.8 PIK34974.1 - 0.013 15.9 0.2 0.013 15.9 0.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3454) cEGF PF12662.7 PIK34975.1 - 5.7e-22 77.3 77.9 7.9e-09 35.3 0.5 13.4 13 1 0 13 13 13 8 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK34975.1 - 3e-15 56.1 21.7 1.7e-09 37.7 5.1 9.9 7 3 3 11 11 11 3 Calcium-binding EGF domain TB PF00683.17 PIK34975.1 - 8.9e-13 47.8 25.7 1.5e-06 27.8 9.9 3.2 2 0 0 2 2 2 2 TB domain FXa_inhibition PF14670.6 PIK34975.1 - 5.1e-12 45.9 88.3 0.0013 19.0 7.4 12.7 13 2 0 13 13 13 8 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK34975.1 - 7.3e-08 32.6 20.3 4.9e-05 23.5 7.4 9.5 10 1 0 10 10 10 2 EGF-like domain hEGF PF12661.7 PIK34975.1 - 0.00019 21.9 21.4 0.002 18.7 7.2 9.7 11 0 0 11 11 11 2 Human growth factor-like EGF Lustrin_cystein PF14625.6 PIK34975.1 - 0.013 15.9 1.8 0.013 15.9 1.8 9.4 8 2 0 9 9 9 0 Lustrin, cysteine-rich repeated domain Plasmod_Pvs28 PF06247.11 PIK34975.1 - 0.014 15.7 18.4 0.31 11.4 4.9 3.7 3 0 0 3 3 3 0 Pvs28 EGF domain DUF229 PF02995.17 PIK34977.1 - 2.4e-34 118.8 0.0 3.9e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 PIK34977.1 - 0.0085 15.5 0.1 0.013 15.0 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 PIK34977.1 - 0.021 14.2 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily DUF1902 PF08972.11 PIK34977.1 - 0.056 13.4 0.4 0.19 11.7 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) SSXT PF05030.12 PIK34977.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 SSXT protein (N-terminal region) SPX PF03105.19 PIK34978.1 - 0.003 17.5 25.6 0.0042 17.1 25.6 1.3 1 1 0 1 1 1 1 SPX domain Ldh_1_N PF00056.23 PIK34979.1 - 4.9e-47 159.6 0.6 8.1e-47 158.9 0.6 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 PIK34979.1 - 1e-21 77.6 0.5 2.7e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 PIK34979.1 - 0.0052 16.4 0.3 0.024 14.2 0.1 2.0 1 1 0 2 2 2 1 Family 4 glycosyl hydrolase 3HCDH_N PF02737.18 PIK34979.1 - 0.06 13.2 0.2 0.092 12.6 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 PIK34979.1 - 0.14 11.7 1.5 0.27 10.8 1.4 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TSP_1 PF00090.19 PIK34980.1 - 0.0051 17.0 3.9 0.0051 17.0 3.9 2.5 2 1 0 2 2 2 1 Thrombospondin type 1 domain TPR_12 PF13424.6 PIK34983.1 - 0.0021 18.3 2.6 3.5 8.0 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat MAP65_ASE1 PF03999.12 PIK34983.1 - 0.0097 14.7 1.4 0.013 14.2 1.4 1.2 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DAO_C PF16901.5 PIK34983.1 - 0.12 12.3 0.1 2.2 8.2 0.0 2.6 3 1 1 4 4 4 0 C-terminal domain of alpha-glycerophosphate oxidase Yuri_gagarin PF15934.5 PIK34983.1 - 0.24 11.2 4.0 0.082 12.7 1.0 1.8 2 1 0 2 2 2 0 Yuri gagarin Pkinase_Tyr PF07714.17 PIK34984.1 - 4.3e-25 88.5 0.0 5e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK34984.1 - 3.2e-07 30.0 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Sushi PF00084.20 PIK34985.1 - 8.3e-06 26.3 1.0 3e-05 24.5 1.0 2.1 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Shisa PF13908.6 PIK34985.1 - 0.025 14.8 0.0 0.025 14.8 0.0 2.1 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator DUF2742 PF10888.8 PIK34985.1 - 0.052 13.8 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2742) EphA2_TM PF14575.6 PIK34985.1 - 0.056 14.3 0.0 0.13 13.2 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Myticin-prepro PF10690.9 PIK34985.1 - 4.8 7.5 6.3 24 5.3 0.2 2.7 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel ZU5 PF00791.20 PIK34986.1 - 1.3e-12 47.8 0.1 4.7e-12 46.1 0.1 1.9 1 0 0 1 1 1 1 ZU5 domain DUF1619 PF07773.11 PIK34986.1 - 0.18 11.7 1.0 5.1 6.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1619) ZU5 PF00791.20 PIK34987.1 - 1.3e-13 51.1 0.0 4e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK34987.1 - 1.3 9.4 5.2 0.85 10.0 0.3 2.6 2 0 0 2 2 2 0 Death effector domain Methyltransf_23 PF13489.6 PIK34988.1 - 5.5e-10 39.3 0.0 1.1e-09 38.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK34988.1 - 8.2e-08 32.9 0.0 2e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK34988.1 - 1e-06 28.6 0.0 2.1e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK34988.1 - 2.4e-06 28.1 0.0 5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK34988.1 - 0.00016 21.1 0.1 0.00028 20.3 0.1 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK34988.1 - 0.0035 18.0 0.0 0.0082 16.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_20 PF12147.8 PIK34988.1 - 0.0061 15.7 0.0 1.3 8.0 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase MTS PF05175.14 PIK34988.1 - 0.015 14.8 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 PIK34988.1 - 0.051 13.3 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_32 PF13679.6 PIK34988.1 - 0.056 13.4 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Arc_trans_TRASH PF08394.10 PIK34988.1 - 0.15 12.4 0.5 0.15 12.4 0.5 2.0 2 0 0 2 2 2 0 Archaeal TRASH domain Avidin PF01382.17 PIK34989.1 - 2.4e-34 118.3 1.7 3.2e-34 117.8 1.7 1.2 1 0 0 1 1 1 1 Avidin family Ank_2 PF12796.7 PIK34990.1 - 3.9e-38 129.9 9.8 1.5e-10 41.5 0.3 6.6 4 3 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK34990.1 - 3.5e-29 100.8 11.5 2e-07 31.4 0.1 8.1 4 3 5 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK34990.1 - 2.9e-25 88.0 17.7 3.1e-07 30.5 0.4 9.1 6 3 4 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK34990.1 - 1.3e-24 83.6 20.8 0.00036 20.8 0.0 10.8 12 1 0 12 12 12 6 Ankyrin repeat Ank PF00023.30 PIK34990.1 - 3.1e-20 71.6 22.1 0.022 15.2 0.0 9.7 9 1 1 10 10 10 6 Ankyrin repeat TPR_MLP1_2 PF07926.12 PIK34991.1 - 0.0056 16.7 4.5 0.0056 16.7 4.5 2.0 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein GIT_CC PF16559.5 PIK34991.1 - 0.27 11.1 4.2 1.1 9.1 4.1 2.1 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3475 PF11961.8 PIK34991.1 - 0.28 11.3 3.2 17 5.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) DUF1664 PF07889.12 PIK34991.1 - 0.96 9.5 4.3 2.5 8.2 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 PIK34991.1 - 5.8 6.4 9.4 7.6 6.0 8.9 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit RRM_1 PF00076.22 PIK34993.1 - 6.4e-08 32.3 0.0 1.3e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HHH_3 PF12836.7 PIK34994.1 - 1.9e-06 28.0 0.0 3.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_6 PF14579.6 PIK34994.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif RVT_1 PF00078.27 PIK34995.1 - 2.3e-07 30.6 0.0 3e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK34997.1 - 1.3e-28 100.0 0.1 1.5e-28 99.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BBS2_Mid PF14783.6 PIK34999.1 - 0.015 15.4 0.0 0.054 13.5 0.0 1.9 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region RhoGEF PF00621.20 PIK35000.1 - 8e-41 140.3 1.2 9.9e-41 140.0 1.2 1.1 1 0 0 1 1 1 1 RhoGEF domain BCDHK_Adom3 PF10436.9 PIK35000.1 - 0.03 14.1 0.5 0.12 12.2 0.3 2.1 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF659 PF04937.15 PIK35000.1 - 0.056 13.3 0.0 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) DUF1722 PF08349.11 PIK35000.1 - 0.11 12.8 1.3 0.41 10.9 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) zf-H2C2_2 PF13465.6 PIK35001.1 - 9e-08 32.2 4.5 6.3e-07 29.5 2.6 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK35001.1 - 9.7e-06 25.8 5.3 0.00073 19.9 0.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35001.1 - 0.017 15.9 5.1 0.5 11.4 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger YyzF PF14116.6 PIK35001.1 - 0.018 15.0 0.1 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 YyzF-like protein PyrI_C PF02748.15 PIK35001.1 - 0.048 13.6 0.1 15 5.6 0.0 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK35001.1 - 0.3 11.4 4.4 5 7.5 1.1 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK35001.1 - 1.8 8.8 6.7 3 8.1 1.5 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger rve PF00665.26 PIK35002.1 - 9.5e-09 35.5 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK35002.1 - 0.0059 16.4 0.0 0.0087 15.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.6 PIK35002.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain Peptidase_A17 PF05380.13 PIK35003.1 - 3.9e-51 173.3 0.1 6.1e-51 172.6 0.1 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK35003.1 - 1.1e-08 34.9 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chlamy_scaf PF09675.10 PIK35003.1 - 0.00064 20.0 0.1 0.0013 19.1 0.1 1.4 1 0 0 1 1 1 1 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) UDPGT PF00201.18 PIK35004.1 - 0.0001 21.3 0.0 0.00012 21.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DUF4715 PF15835.5 PIK35004.1 - 0.031 14.4 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) CHAT PF12770.7 PIK35005.1 - 4.4e-49 167.4 0.1 5.9e-47 160.5 0.0 2.3 2 0 0 2 2 2 2 CHAT domain PUB PF09409.10 PIK35005.1 - 0.0047 16.8 0.0 0.66 10.0 0.0 2.7 2 0 0 2 2 2 2 PUB domain TPR_12 PF13424.6 PIK35006.1 - 5.9e-75 247.6 48.2 8.9e-12 45.1 1.3 9.6 5 3 7 12 12 12 11 Tetratricopeptide repeat TPR_7 PF13176.6 PIK35006.1 - 2.8e-70 227.3 43.5 1.2e-06 28.1 0.2 16.5 16 0 0 16 16 16 15 Tetratricopeptide repeat TPR_1 PF00515.28 PIK35006.1 - 3.7e-63 207.0 58.3 6.6e-05 22.6 0.3 16.6 17 0 0 17 17 16 14 Tetratricopeptide repeat TPR_8 PF13181.6 PIK35006.1 - 1.9e-37 124.3 50.2 3.6e-05 23.6 0.2 15.4 16 0 0 16 16 15 10 Tetratricopeptide repeat TPR_10 PF13374.6 PIK35006.1 - 3.6e-36 122.0 41.4 0.0027 17.5 0.1 15.1 16 0 0 16 16 16 10 Tetratricopeptide repeat TPR_2 PF07719.17 PIK35006.1 - 1.9e-35 118.1 56.6 5.3e-05 23.0 1.4 15.6 15 0 0 15 15 15 10 Tetratricopeptide repeat TPR_4 PF07721.14 PIK35006.1 - 3.5e-16 58.1 1.4 0.54 11.0 0.0 10.0 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK35006.1 - 8.8e-14 51.6 26.9 0.00016 21.1 0.2 5.0 1 1 1 4 4 4 4 MalT-like TPR region TPR_14 PF13428.6 PIK35006.1 - 1.1e-10 41.4 19.9 0.66 11.0 0.1 12.3 13 1 2 15 15 13 2 Tetratricopeptide repeat Rapsyn_N PF10579.9 PIK35006.1 - 1.2e-08 35.0 18.3 0.066 13.3 0.0 9.7 6 5 6 12 12 12 2 Rapsyn N-terminal myristoylation and linker region TPR_6 PF13174.6 PIK35006.1 - 1.2e-08 35.0 18.8 0.15 12.8 0.0 9.8 10 1 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK35006.1 - 1.3e-08 34.6 30.4 0.68 10.4 0.1 11.8 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK35006.1 - 8e-08 32.8 20.8 0.64 10.7 0.2 9.1 7 3 3 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK35006.1 - 8.8e-06 26.1 26.5 0.089 13.3 0.0 8.6 7 2 4 11 11 10 5 Tetratricopeptide repeat TPR_9 PF13371.6 PIK35006.1 - 2e-05 24.6 6.1 1.1 9.4 0.0 7.2 6 2 3 9 9 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK35006.1 - 2.9e-05 23.6 36.5 2.3 8.0 0.0 12.0 12 0 0 12 12 12 1 TPR repeat RPN7 PF10602.9 PIK35006.1 - 4.4e-05 23.3 12.8 3.3 7.4 0.2 6.7 4 2 1 5 5 5 1 26S proteasome subunit RPN7 DUF4807 PF16065.5 PIK35006.1 - 0.00027 20.6 12.4 0.66 9.6 0.1 6.0 3 2 2 5 5 5 2 Domain of unknown function (DUF4807) ComR_TPR PF18710.1 PIK35006.1 - 0.043 13.4 1.2 0.25 10.9 0.1 2.7 2 0 0 2 2 2 0 ComR tetratricopeptide Paf67 PF10255.9 PIK35006.1 - 0.09 11.8 0.0 0.09 11.8 0.0 3.7 4 1 0 4 4 4 0 RNA polymerase I-associated factor PAF67 DUF2989 PF11207.8 PIK35006.1 - 0.13 12.1 11.2 0.5 10.1 0.0 4.9 5 1 1 6 6 6 0 Protein of unknown function (DUF2989) ANAPC5 PF12862.7 PIK35006.1 - 2 8.6 23.6 6.3 6.9 0.5 7.0 5 1 1 6 6 6 0 Anaphase-promoting complex subunit 5 Fis1_TPR_C PF14853.6 PIK35006.1 - 8.4 6.6 20.3 14 5.8 0.8 6.8 8 0 0 8 8 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 PIK35007.1 - 9.1e-07 28.5 0.1 0.00067 19.6 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK35007.1 - 9e-06 25.4 0.2 0.011 15.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK35007.1 - 1.2e-05 25.7 2.7 0.002 18.8 0.8 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK35007.1 - 0.00017 21.3 0.0 0.0014 18.3 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK35007.1 - 0.00051 20.5 0.1 0.018 15.6 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK35007.1 - 0.0015 18.8 0.2 0.89 9.9 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK35007.1 - 0.019 15.2 0.0 7.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK35007.1 - 0.02 15.5 6.5 1.2 10.0 1.9 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK35007.1 - 0.02 14.8 0.0 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK35007.1 - 0.083 13.6 0.3 7.8 7.4 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 PIK35007.1 - 0.18 11.9 0.1 13 5.8 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) zf-CCHC PF00098.23 PIK35008.1 - 7.1e-05 22.7 15.2 0.0039 17.2 3.3 3.2 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35008.1 - 7.5e-05 22.5 6.2 0.0035 17.1 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35008.1 - 0.00016 21.3 14.3 0.34 10.7 0.4 3.6 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK35008.1 - 2.5 8.4 11.9 0.54 10.5 6.1 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain I-set PF07679.16 PIK35009.1 - 7.1e-34 115.7 1.8 6.4e-12 45.4 0.0 4.1 3 1 1 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35009.1 - 1.2e-31 109.1 1.1 1.1e-12 48.4 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK35009.1 - 6.1e-22 77.8 0.6 5.5e-08 33.0 0.0 4.2 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK35009.1 - 1.7e-19 69.8 0.2 0.00043 20.4 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_6 PF18452.1 PIK35009.1 - 2e-16 59.3 1.7 0.00022 20.7 0.0 4.7 4 1 1 5 5 5 4 Immunoglobulin domain V-set PF07686.17 PIK35009.1 - 2.9e-14 53.1 2.0 0.015 15.4 0.0 5.2 3 1 2 5 5 5 4 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK35009.1 - 8.7e-07 29.3 0.0 0.41 11.1 0.0 4.2 3 1 1 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK35009.1 - 7.5e-06 25.9 0.5 1.4 9.0 0.0 4.2 3 1 1 4 4 4 1 Izumo-like Immunoglobulin domain PLAC PF08686.11 PIK35009.1 - 0.00069 20.3 3.9 0.0014 19.3 3.9 1.6 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Receptor_2B4 PF11465.8 PIK35009.1 - 0.0057 16.8 0.3 11 6.3 0.0 3.9 3 1 1 4 4 4 1 Natural killer cell receptor 2B4 C2-set PF05790.15 PIK35009.1 - 0.034 14.3 0.0 4.8 7.4 0.0 3.2 3 1 1 4 4 4 0 Immunoglobulin C2-set domain Kunitz_BPTI PF00014.23 PIK35010.1 - 9.2e-25 86.6 26.3 5.2e-16 58.6 12.3 3.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain TSP_1 PF00090.19 PIK35010.1 - 5.1e-20 71.4 79.4 2e-05 24.7 4.6 8.4 8 1 0 8 8 8 6 Thrombospondin type 1 domain TSP_1 PF00090.19 PIK35011.1 - 1.7e-08 34.5 6.1 3.6e-08 33.5 6.1 1.6 1 0 0 1 1 1 1 Thrombospondin type 1 domain DUF4215 PF13948.6 PIK35011.1 - 2.8 8.5 8.5 2 8.9 3.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4215) PGM_PMM_I PF02878.16 PIK35012.1 - 3.2e-34 117.6 0.3 4.7e-34 117.0 0.3 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 PIK35012.1 - 1.6e-29 102.4 0.0 2.9e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III GARS_N PF02844.15 PIK35012.1 - 0.11 13.3 0.2 2.1 9.2 0.2 2.5 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain IL17 PF06083.11 PIK35013.1 - 1.3e-21 76.9 1.3 2e-21 76.2 1.3 1.2 1 0 0 1 1 1 1 Interleukin-17 Y_phosphatase PF00102.27 PIK35014.1 - 0.0063 16.1 0.0 0.0095 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK35015.1 - 0.06 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain PDZ PF00595.24 PIK35016.1 - 6e-18 65.0 2.0 4.3e-05 23.8 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK35016.1 - 7.3e-06 25.7 0.2 0.098 12.5 0.0 3.6 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 PIK35017.1 - 1.4e-19 70.2 1.7 2.6e-19 69.4 1.7 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK35017.1 - 1.3e-11 44.1 0.1 2.2e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK35017.1 - 6e-08 32.9 0.2 1e-07 32.1 0.2 1.3 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 PIK35017.1 - 0.039 13.9 0.1 0.092 12.7 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain IKI3 PF04762.12 PIK35018.1 - 2.9e-241 803.3 9.0 1.5e-224 748.1 1.4 3.1 1 1 1 2 2 2 2 IKI3 family ANAPC4_WD40 PF12894.7 PIK35018.1 - 0.00092 19.5 4.5 3.9 7.8 0.0 6.1 3 3 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1759 PF03564.15 PIK35018.1 - 0.019 14.9 5.7 0.02 14.8 0.8 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1759) eIF2A PF08662.11 PIK35018.1 - 0.38 10.6 2.5 9.8 6.0 0.0 3.8 4 2 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A KxDL PF10241.9 PIK35019.1 - 4.6e-29 100.5 0.3 7.3e-29 99.9 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein TolA_bind_tri PF16331.5 PIK35019.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.3 3 0 0 3 3 3 0 TolA binding protein trimerisation Methyltransf_PK PF05891.12 PIK35020.1 - 8.4e-82 273.9 0.0 9.5e-82 273.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 PIK35020.1 - 1e-05 24.9 0.0 1.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 PIK35020.1 - 1.2e-05 25.9 0.0 2.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK35020.1 - 5.1e-05 23.9 0.0 7.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK35020.1 - 0.00035 21.3 0.0 0.00052 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK35020.1 - 0.02 14.7 0.0 0.069 13.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 PIK35020.1 - 0.056 13.0 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Spermine_synth PF01564.17 PIK35020.1 - 0.08 12.3 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain RrnaAD PF00398.20 PIK35020.1 - 0.086 11.9 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Pkinase PF00069.25 PIK35021.1 - 9.2e-31 107.2 0.0 1.5e-30 106.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35021.1 - 1e-15 57.8 0.0 1.4e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK35021.1 - 0.0028 17.0 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK35021.1 - 0.066 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FAM199X PF15814.5 PIK35021.1 - 4.4 6.3 6.2 7.1 5.6 6.2 1.3 1 0 0 1 1 1 0 Protein family FAM199X KAP PF05804.12 PIK35022.1 - 0 1197.9 29.7 0 1050.8 20.3 2.0 1 1 1 2 2 2 2 Kinesin-associated protein (KAP) Arm PF00514.23 PIK35022.1 - 4.2e-05 23.4 6.9 1.6 8.9 0.1 5.9 5 1 0 5 5 5 3 Armadillo/beta-catenin-like repeat FPL PF09758.9 PIK35022.1 - 0.067 13.2 9.3 0.029 14.4 5.5 2.5 2 1 0 2 2 2 0 Uncharacterised conserved protein Cnd1 PF12717.7 PIK35022.1 - 4.4 7.3 11.8 19 5.3 0.2 3.6 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Ran-binding PF05508.11 PIK35023.1 - 0.0017 17.4 1.7 0.05 12.6 0.2 2.5 2 0 0 2 2 2 2 RanGTP-binding protein Med30 PF11315.8 PIK35023.1 - 0.0077 16.4 0.4 0.0077 16.4 0.4 3.0 3 0 0 3 3 3 1 Mediator complex subunit 30 Glyco_hydro_88 PF07470.13 PIK35023.1 - 0.068 12.2 0.0 0.26 10.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl Hydrolase Family 88 Phasin PF05597.11 PIK35023.1 - 0.4 10.7 5.5 2.9 7.9 0.2 2.7 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) NPV_P10 PF05531.12 PIK35023.1 - 0.4 11.2 4.7 6.3 7.3 0.1 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TIMP PF00965.17 PIK35024.1 - 2.1e-18 66.8 5.4 2.4e-18 66.6 3.8 1.8 1 1 1 2 2 2 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK35024.1 - 0.00024 20.9 0.1 0.001 18.9 0.0 2.1 1 1 1 2 2 2 1 UNC-6/NTR/C345C module TIMP PF00965.17 PIK35025.1 - 1.1e-24 87.2 2.5 1.4e-24 86.9 2.5 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK35025.1 - 5.9e-06 26.1 0.3 1.1e-05 25.2 0.1 1.6 1 1 0 1 1 1 1 UNC-6/NTR/C345C module Fibrinogen_C PF00147.18 PIK35026.1 - 7.1e-67 225.4 5.2 8.5e-67 225.2 5.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK35026.1 - 0.0003 20.2 0.7 0.00043 19.7 0.2 1.6 2 0 0 2 2 2 1 Fibrillar collagen C-terminal domain Y_phosphatase PF00102.27 PIK35027.1 - 1.4e-113 378.2 3.0 2.4e-53 181.1 0.0 3.1 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK35027.1 - 2.6e-11 43.4 0.1 1.4e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK35027.1 - 1e-08 35.5 0.0 2.2e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK35027.1 - 6.3e-07 29.6 0.0 4.7e-05 23.6 0.0 2.8 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK35027.1 - 0.0011 18.6 0.2 0.48 10.0 0.0 2.6 2 0 0 2 2 2 2 Tyrosine phosphatase family GTP_EFTU PF00009.27 PIK35027.1 - 0.0062 16.1 0.0 0.13 11.8 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain CDKN3 PF05706.12 PIK35027.1 - 0.012 15.3 0.0 5.2 6.7 0.0 2.6 2 1 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Myotub-related PF06602.14 PIK35027.1 - 0.025 13.5 0.1 0.31 9.9 0.0 2.1 2 0 0 2 2 2 0 Myotubularin-like phosphatase domain Alpha-amylase PF00128.24 PIK35028.1 - 1.5e-16 60.9 0.0 2.3e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase PF00128.24 PIK35029.1 - 1.2e-14 54.7 0.0 2.6e-14 53.5 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 PIK35029.1 - 7.2e-13 48.8 0.2 1.8e-12 47.5 0.2 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain JmjC PF02373.22 PIK35030.1 - 8.9e-22 77.7 0.0 1.8e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 PIK35030.1 - 2.3e-12 46.7 0.0 6e-12 45.3 0.0 1.8 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H_2 PF13832.6 PIK35031.1 - 2.7e-14 53.2 3.3 2.7e-14 53.2 3.3 2.7 2 0 0 2 2 2 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 PIK35031.1 - 4.2e-05 23.1 2.0 0.00012 21.7 2.0 1.9 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 PIK35031.1 - 0.00066 19.9 12.6 0.0035 17.6 0.5 4.4 2 1 1 3 3 3 1 PHD-like zinc-binding domain zf-RING_2 PF13639.6 PIK35033.1 - 1.4e-06 28.5 10.7 1.4e-06 28.5 10.7 1.8 2 0 0 2 2 2 1 Ring finger domain Pkinase PF00069.25 PIK35033.1 - 0.003 16.9 0.0 0.006 16.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain PHD PF00628.29 PIK35033.1 - 0.0038 17.1 10.3 0.0038 17.1 10.3 2.6 3 0 0 3 3 3 1 PHD-finger zf-ANAPC11 PF12861.7 PIK35033.1 - 0.0065 16.5 5.2 0.015 15.3 5.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 PIK35033.1 - 0.25 11.6 7.6 0.64 10.2 7.6 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C6H2 PF15801.5 PIK35033.1 - 0.44 10.9 9.9 5.7 7.3 3.4 2.7 1 1 1 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding RINGv PF12906.7 PIK35033.1 - 0.55 10.4 11.5 1.6 8.9 11.5 1.9 1 0 0 1 1 1 0 RING-variant domain zf-rbx1 PF12678.7 PIK35033.1 - 0.67 10.3 11.3 2.9 8.2 11.3 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-Di19 PF05605.12 PIK35033.1 - 3.9 7.8 8.5 20 5.6 1.2 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_4 PF14570.6 PIK35033.1 - 9.6 6.1 13.2 1.8 8.5 6.6 2.7 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain DHC_N2 PF08393.13 PIK35034.1 - 1.3e-136 455.9 7.7 1.3e-136 455.9 7.7 3.9 4 1 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 PIK35034.1 - 2.6e-134 447.4 0.1 6.5e-66 222.5 0.0 3.0 2 1 1 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 PIK35034.1 - 2.1e-104 348.5 0.6 2.1e-104 348.5 0.6 3.1 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK35034.1 - 1e-91 306.0 3.2 1e-91 306.0 3.2 3.6 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 PIK35034.1 - 3e-77 258.2 0.1 1.2e-74 249.8 0.0 3.6 4 0 0 4 4 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 PIK35034.1 - 2.8e-60 202.9 0.2 1.6e-59 200.4 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK35034.1 - 2.7e-46 156.5 0.1 5.2e-45 152.4 0.0 3.1 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK35034.1 - 3.6e-35 121.6 17.2 3.7e-32 111.7 15.6 2.6 1 1 1 2 2 2 2 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 PIK35034.1 - 3.5e-24 85.3 0.1 3.3e-23 82.2 0.1 2.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 PIK35034.1 - 2.5e-20 72.5 0.1 2.5e-19 69.3 0.2 2.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 PIK35034.1 - 6.9e-18 65.0 0.0 0.00014 21.8 0.0 5.7 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK35034.1 - 1.6e-07 31.7 0.0 0.068 13.4 0.0 5.6 5 0 0 5 5 5 1 AAA domain AAA PF00004.29 PIK35034.1 - 7.9e-07 29.6 0.0 0.18 12.2 0.0 4.2 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK35034.1 - 5.6e-06 26.7 0.1 0.72 10.3 0.0 5.0 5 0 0 5 5 5 2 RNA helicase T2SSE PF00437.20 PIK35034.1 - 4.6e-05 22.6 3.3 0.00015 20.9 0.0 3.1 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_16 PF13191.6 PIK35034.1 - 5.5e-05 23.6 2.5 0.16 12.4 0.0 4.4 4 1 0 4 4 3 2 AAA ATPase domain AAA_18 PF13238.6 PIK35034.1 - 0.0017 18.9 0.0 0.26 11.8 0.0 4.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 PIK35034.1 - 0.011 15.5 0.1 2.1 8.0 0.1 3.2 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 PIK35034.1 - 0.014 14.7 0.3 12 5.2 0.0 3.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family Mg_chelatase PF01078.21 PIK35034.1 - 0.017 14.5 0.0 6.7 6.0 0.0 3.6 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI ResIII PF04851.15 PIK35034.1 - 0.062 13.3 0.3 2 8.4 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 PIK35034.1 - 0.083 12.8 0.3 0.32 10.9 0.0 2.2 2 0 0 2 2 1 0 RsgA GTPase Sigma54_activat PF00158.26 PIK35034.1 - 0.098 12.4 0.1 1.2 8.8 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain HycH PF07450.11 PIK35034.1 - 0.57 10.6 2.5 1.5 9.2 0.0 3.1 3 0 0 3 3 2 0 Formate hydrogenlyase maturation protein HycH ABC_tran PF00005.27 PIK35034.1 - 2.5 8.6 5.0 18 5.9 0.0 4.4 4 0 0 4 4 4 0 ABC transporter NPV_P10 PF05531.12 PIK35034.1 - 9.6 6.7 19.3 5.1 7.6 0.4 5.3 4 0 0 4 4 3 0 Nucleopolyhedrovirus P10 protein Neur_chan_LBD PF02931.23 PIK35035.1 - 5.8e-11 42.3 0.0 7.2e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK35035.1 - 1.6e-10 41.4 0.8 2.1e-10 41.0 0.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region NAP PF00956.18 PIK35036.1 - 1.1e-16 60.9 7.4 1.1e-16 60.9 7.4 3.1 2 1 1 3 3 3 1 Nucleosome assembly protein (NAP) Shisa PF13908.6 PIK35037.1 - 0.00044 20.5 0.0 0.00058 20.1 0.0 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator ECSCR PF15820.5 PIK35037.1 - 0.001 18.8 0.3 0.0017 18.1 0.3 1.3 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.6 PIK35037.1 - 0.0049 16.8 0.1 0.0073 16.2 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family Syndecan PF01034.20 PIK35037.1 - 0.12 12.3 0.1 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 Syndecan domain RVT_1 PF00078.27 PIK35038.1 - 1.4e-15 57.4 0.0 1.8e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zn-ribbon_8 PF09723.10 PIK35040.1 - 0.027 14.6 0.2 0.56 10.4 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DUF1389 PF07146.11 PIK35040.1 - 0.15 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1389) Albumin_I PF08027.11 PIK35042.1 - 0.2 11.3 4.0 0.57 9.8 4.0 1.8 1 0 0 1 1 1 0 Albumin I chain b SLS PF14611.6 PIK35043.1 - 0.046 13.6 0.3 0.046 13.6 0.3 1.9 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator TipE PF16972.5 PIK35043.1 - 0.21 10.7 0.2 0.3 10.2 0.2 1.3 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE DUF4050 PF13259.6 PIK35043.1 - 0.99 9.7 6.0 0.34 11.2 2.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4050) RVT_1 PF00078.27 PIK35044.1 - 1.1e-40 139.6 0.0 1.7e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK35044.1 - 1.4e-06 28.9 1.5 3.9e-06 27.5 1.5 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK35045.1 - 6e-23 81.5 0.0 7.1e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo5 PF09810.9 PIK35045.1 - 0.21 11.1 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease DUF659 PF04937.15 PIK35046.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Viral_P18 PF04521.13 PIK35049.1 - 0.047 13.5 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein RVT_1 PF00078.27 PIK35050.1 - 5.4e-21 75.1 0.1 1.1e-20 74.2 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PSI PF01437.25 PIK35052.1 - 0.0001 22.8 6.2 0.0001 22.8 6.2 7.1 3 1 1 4 4 4 2 Plexin repeat Laminin_EGF PF00053.24 PIK35052.1 - 0.0014 18.8 12.7 0.0014 18.8 12.7 7.8 5 3 3 8 8 8 3 Laminin EGF domain zf-C4 PF00105.18 PIK35053.1 - 2.5e-23 82.3 14.5 4.3e-23 81.5 14.5 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK35053.1 - 9.6e-18 64.5 0.8 1.8e-17 63.6 0.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SOG2 PF10428.9 PIK35053.1 - 0.0042 16.4 8.6 0.0056 16.0 8.6 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein Macoilin PF09726.9 PIK35053.1 - 0.033 12.8 3.8 0.035 12.7 3.8 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 PIK35053.1 - 0.034 13.0 3.5 0.038 12.8 3.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 PIK35053.1 - 0.061 13.2 7.7 0.086 12.7 7.7 1.2 1 0 0 1 1 1 0 SPX domain Suf PF05843.14 PIK35053.1 - 0.13 12.2 0.9 0.2 11.6 0.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PAP1 PF08601.10 PIK35053.1 - 0.17 11.5 20.5 0.25 11.0 20.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 GREB1 PF15782.5 PIK35053.1 - 0.76 6.8 11.8 1 6.4 11.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tmemb_cc2 PF10267.9 PIK35053.1 - 0.89 8.6 4.5 1.4 8.0 4.5 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Lin-8 PF03353.15 PIK35053.1 - 1.3 8.5 4.2 2 7.9 4.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TEX19 PF15553.6 PIK35053.1 - 2.4 8.1 5.5 15 5.5 0.0 2.6 2 1 0 2 2 2 0 Testis-expressed protein 19 TAF4 PF05236.14 PIK35053.1 - 2.8 7.6 8.0 0.4 10.4 4.2 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family RAP1 PF07218.11 PIK35053.1 - 9.8 4.3 18.3 12 4.1 14.9 2.0 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Death PF00531.22 PIK35054.1 - 7.2e-14 51.7 0.8 1.6e-13 50.6 0.8 1.6 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK35054.1 - 6.2e-13 48.9 0.1 1.3e-12 47.9 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK35054.1 - 0.00017 21.8 1.4 0.0054 17.0 1.0 2.5 2 0 0 2 2 2 1 Death effector domain LRR_3 PF07725.12 PIK35054.1 - 0.11 12.4 0.5 0.58 10.1 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich Repeat DUF2653 PF10850.8 PIK35054.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Cyanate_lyase PF02560.14 PIK35054.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Cyanate lyase C-terminal domain DED PF01335.21 PIK35055.1 - 0.0013 19.0 0.1 0.0019 18.5 0.1 1.3 1 0 0 1 1 1 1 Death effector domain Pkinase_Tyr PF07714.17 PIK35058.1 - 4.5e-10 39.2 0.3 7.1e-10 38.6 0.3 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35058.1 - 1.1e-05 25.0 0.3 0.00029 20.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain C2-set_2 PF08205.12 PIK35059.1 - 5.8e-06 26.3 0.7 0.033 14.3 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK35059.1 - 6.2e-06 26.2 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK35059.1 - 5e-05 23.8 1.8 0.56 10.8 0.0 4.6 3 2 1 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK35059.1 - 0.00015 21.9 1.0 0.92 9.7 0.0 4.6 3 2 2 5 5 5 1 Immunoglobulin domain DUF5484 PF17583.2 PIK35059.1 - 0.00053 19.6 0.0 1.2 8.9 0.0 2.8 2 0 0 2 2 2 2 Family of unknown function (DUF5484) I-set PF07679.16 PIK35059.1 - 0.0018 18.3 0.0 4.2 7.5 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain Marek_A PF02124.15 PIK35059.1 - 0.0022 17.9 3.3 0.0065 16.3 2.6 2.2 1 1 0 1 1 1 1 Marek's disease glycoprotein A TMEM154 PF15102.6 PIK35059.1 - 0.0027 17.6 0.1 0.0071 16.3 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family V-set PF07686.17 PIK35059.1 - 0.012 15.8 0.2 0.085 13.0 0.0 2.5 3 0 0 3 3 3 0 Immunoglobulin V-set domain EphA2_TM PF14575.6 PIK35059.1 - 0.021 15.7 0.0 0.059 14.2 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 PIK35059.1 - 0.034 14.4 0.1 0.07 13.4 0.1 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator AAA_25 PF13481.6 PIK35059.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 PIK35062.1 - 1.1 8.0 7.1 1.3 7.7 7.1 1.1 1 0 0 1 1 1 0 Presenilin Na_Ca_ex PF01699.24 PIK35063.1 - 1.1e-20 74.1 5.5 1.3e-20 73.9 5.5 1.0 1 0 0 1 1 1 1 Sodium/calcium exchanger protein PT-VENN PF04829.13 PIK35063.1 - 0.31 11.1 1.8 0.56 10.3 1.8 1.3 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Pkinase_Tyr PF07714.17 PIK35064.1 - 4.1e-09 36.1 0.0 5.1e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase V-set PF07686.17 PIK35065.1 - 3.8e-10 39.9 0.5 0.00042 20.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK35065.1 - 3.4e-05 23.8 0.2 0.34 11.0 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK35065.1 - 3.7e-05 24.2 3.2 5.7 7.6 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK35065.1 - 0.0019 18.3 0.6 3.6 7.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 PIK35065.1 - 0.087 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LapA_dom PF06305.11 PIK35065.1 - 1.2 9.0 11.2 0.7 9.8 0.5 3.6 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain zf-CCHC_6 PF15288.6 PIK35066.1 - 0.35 10.7 5.9 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35066.1 - 1.2 8.9 8.4 0.065 13.0 2.2 2.2 3 0 0 3 3 3 0 Zinc knuckle GPS PF01825.21 PIK35067.1 - 6.9e-15 55.3 2.5 1.2e-14 54.5 2.5 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK35067.1 - 9.4e-09 34.9 2.4 2.1e-08 33.8 2.4 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) UPF0139 PF03669.13 PIK35067.1 - 0.024 14.5 0.2 0.063 13.1 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) 7TM_GPCR_Srh PF10318.9 PIK35067.1 - 0.026 13.6 10.1 0.046 12.8 10.1 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh Bax1-I PF01027.20 PIK35067.1 - 0.075 12.9 8.1 0.14 12.0 8.1 1.3 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 GAIN PF16489.5 PIK35067.1 - 0.087 12.2 2.3 0.21 11.0 2.3 1.6 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain Terminase_3C PF17288.2 PIK35068.1 - 0.00071 20.0 0.5 0.00094 19.6 0.5 1.3 1 0 0 1 1 1 1 Terminase RNAseH like domain HU-CCDC81_bac_2 PF18175.1 PIK35068.1 - 0.077 12.9 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 SMI1_KNR4 PF09346.10 PIK35069.1 - 0.0048 17.3 0.2 0.0075 16.7 0.2 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) GSDH PF07995.11 PIK35069.1 - 0.014 14.7 0.0 2.7 7.2 0.0 2.1 1 1 1 2 2 2 0 Glucose / Sorbosone dehydrogenase NTR PF01759.21 PIK35070.1 - 2.1e-05 24.3 0.2 3.1e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module AhpC-TSA PF00578.21 PIK35071.1 - 8e-08 32.2 0.0 3.4e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family AhpC-TSA_2 PF13911.6 PIK35071.1 - 4.2e-07 30.1 0.0 9.4e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 PIK35071.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.5 2 0 0 2 2 2 0 Redoxin Aquarius_N PF16399.5 PIK35072.1 - 1.1e-206 688.5 19.3 1.3e-68 231.9 1.0 5.1 4 1 1 5 5 5 5 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 PIK35072.1 - 5.1e-27 94.8 0.0 5.4e-26 91.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK35072.1 - 8.5e-20 71.6 0.0 9.6e-19 68.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK35072.1 - 4e-07 30.5 0.0 1.2e-06 29.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK35072.1 - 1.3e-05 25.2 0.0 5e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK35072.1 - 0.00046 20.0 0.1 0.0013 18.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 PIK35072.1 - 0.00046 19.8 0.0 0.0058 16.2 0.0 2.4 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Parvo_NS1 PF01057.17 PIK35072.1 - 0.0012 18.0 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 PIK35072.1 - 0.0014 18.4 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK35072.1 - 0.0075 16.7 0.0 0.023 15.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RecA PF00154.21 PIK35072.1 - 0.014 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein UvrD_C_2 PF13538.6 PIK35072.1 - 0.014 15.2 0.2 0.032 14.1 0.2 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DnaB_C PF03796.15 PIK35072.1 - 0.016 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DUF2075 PF09848.9 PIK35072.1 - 0.021 14.1 3.4 0.031 13.5 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK35072.1 - 0.033 14.6 0.1 0.27 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain PhoH PF02562.16 PIK35072.1 - 0.034 13.6 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 PIK35072.1 - 0.041 14.1 0.1 0.27 11.5 0.1 2.3 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 PIK35072.1 - 0.07 12.5 0.2 0.32 10.3 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_5 PF07728.14 PIK35072.1 - 0.14 12.2 0.0 0.45 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TMEM132D_N PF15705.5 PIK35073.1 - 1.3 8.9 7.4 47 3.8 0.0 5.2 2 2 6 8 8 8 0 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term L_biotic_typeA PF04604.13 PIK35073.1 - 4 7.4 14.4 35 4.3 0.1 6.2 8 0 0 8 8 8 0 Type-A lantibiotic DUF1180 PF06679.12 PIK35074.1 - 0.0026 18.2 0.3 0.0026 18.2 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1180) TMEM154 PF15102.6 PIK35074.1 - 0.013 15.4 0.8 0.013 15.4 0.8 2.2 2 0 0 2 2 2 0 TMEM154 protein family BRO1 PF03097.18 PIK35075.1 - 2e-13 49.9 0.1 1e-12 47.6 0.1 1.8 2 0 0 2 2 2 1 BRO1-like domain Glyco_transf_43 PF03360.16 PIK35077.1 - 1.2e-60 204.9 0.0 1.4e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 7tm_1 PF00001.21 PIK35078.1 - 2.5e-13 50.0 5.6 3.4e-13 49.5 5.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRIMA1 PF16101.5 PIK35078.1 - 0.0014 18.7 1.8 0.0032 17.5 1.4 1.9 1 1 0 1 1 1 1 Proline-rich membrane anchor 1 7TM_GPCR_Srsx PF10320.9 PIK35078.1 - 0.012 15.0 2.9 0.016 14.6 2.9 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2852 PF11014.8 PIK35078.1 - 0.044 14.0 0.1 0.13 12.4 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) Fz PF01392.22 PIK35079.1 - 2.5e-14 53.8 12.4 2.2e-07 31.4 3.0 3.1 2 1 0 2 2 2 2 Fz domain EGF PF00008.27 PIK35079.1 - 0.0013 19.0 9.6 0.0013 19.0 9.6 2.9 3 0 0 3 3 3 1 EGF-like domain YrpD PF15493.6 PIK35079.1 - 0.081 12.8 0.9 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function, YrpD ETRAMP PF09716.10 PIK35079.1 - 0.27 11.3 2.4 0.27 11.3 0.9 1.8 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) zf-RING_UBOX PF13445.6 PIK35080.1 - 5.1e-09 36.0 7.2 5.1e-09 36.0 7.2 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK35080.1 - 3.8e-08 33.1 9.3 3.8e-08 33.1 9.3 3.9 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK35080.1 - 4.8e-07 29.5 8.5 4.8e-07 29.5 8.5 4.9 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35080.1 - 1.5e-06 27.9 9.7 1.5e-06 27.9 9.7 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK35080.1 - 2.1e-06 27.8 9.9 2.1e-06 27.8 9.9 4.3 4 2 1 5 5 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK35080.1 - 9.7e-06 25.5 7.8 9.7e-06 25.5 7.8 4.6 5 0 0 5 5 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK35080.1 - 0.0037 17.1 9.9 0.0037 17.1 9.9 4.0 4 0 0 4 4 2 1 Prokaryotic RING finger family 4 APG17 PF04108.12 PIK35080.1 - 0.0056 15.8 1.1 0.0056 15.8 1.1 2.3 1 1 0 2 2 2 1 Autophagy protein Apg17 zf-B_box PF00643.24 PIK35080.1 - 0.0072 16.5 15.4 0.0072 16.5 15.4 5.1 6 0 0 6 6 4 2 B-box zinc finger Apolipoprotein PF01442.18 PIK35080.1 - 0.0081 16.1 9.1 0.015 15.2 9.1 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Mannitol_dh_C PF08125.13 PIK35080.1 - 0.041 13.4 0.0 0.094 12.2 0.0 1.6 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain FAM184 PF15665.5 PIK35080.1 - 0.11 12.3 17.4 0.28 10.9 17.4 1.7 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Nore1-SARAH PF16517.5 PIK35080.1 - 0.27 11.2 2.0 43 4.1 0.1 3.8 3 0 0 3 3 3 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain KELK PF15796.5 PIK35080.1 - 0.29 11.6 21.9 0.94 10.0 1.2 3.9 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase kleA_kleC PF17383.2 PIK35080.1 - 0.62 10.4 4.6 0.57 10.5 0.7 2.6 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A YtxH PF12732.7 PIK35080.1 - 0.94 10.1 6.7 0.71 10.4 1.6 2.6 2 0 0 2 2 2 0 YtxH-like protein Methyltransf_14 PF08484.11 PIK35080.1 - 1.4 8.7 5.5 0.62 9.9 1.7 2.3 1 1 0 2 2 2 0 C-methyltransferase C-terminal domain Emaravirus_P4 PF16505.5 PIK35080.1 - 1.6 7.7 8.0 10 5.0 3.8 2.3 1 1 1 2 2 2 0 P4 movement protein of Emaravirus, and the 30K superfamily DUF1043 PF06295.12 PIK35080.1 - 1.9 8.5 8.8 0.11 12.5 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Baculo_PEP_C PF04513.12 PIK35080.1 - 2.3 8.3 7.6 4.2 7.4 0.4 2.6 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ubiq_cyt_C_chap PF03981.12 PIK35081.1 - 1.3e-36 125.8 1.5 1.7e-36 125.4 1.5 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Erf4 PF10256.9 PIK35081.1 - 0.042 13.9 0.0 3.5 7.8 0.0 2.9 2 1 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family LIDHydrolase PF10230.9 PIK35082.1 - 4.8e-37 128.0 0.0 5.9e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 PIK35082.1 - 0.00025 20.4 0.0 0.00032 20.0 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 PIK35082.1 - 0.0099 15.8 0.0 0.078 12.8 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_6 PF12697.7 PIK35082.1 - 0.035 14.7 0.0 0.061 13.9 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 PIK35082.1 - 0.058 12.9 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 PIK35082.1 - 0.069 12.8 0.0 0.16 11.6 0.0 1.6 1 1 0 2 2 2 0 alpha/beta hydrolase fold LCAT PF02450.15 PIK35082.1 - 0.23 10.6 0.0 0.32 10.1 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Methyltransf_25 PF13649.6 PIK35083.1 - 1.4e-05 25.7 0.0 2.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK35083.1 - 3.1e-05 24.6 0.0 5.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK35083.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Lipase PF00151.19 PIK35084.1 - 6.1e-80 269.0 0.2 1.2e-79 268.1 0.2 1.4 1 1 0 1 1 1 1 Lipase DUF900 PF05990.12 PIK35084.1 - 1.8e-06 27.6 0.3 2.5e-06 27.2 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 PIK35084.1 - 7.8e-05 23.4 0.1 0.0002 22.0 0.0 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK35084.1 - 0.0049 16.2 0.1 0.0078 15.5 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 PIK35084.1 - 0.0054 16.3 0.1 0.008 15.7 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 PIK35084.1 - 0.0078 16.1 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 PIK35084.1 - 0.047 13.6 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) Ser_hydrolase PF06821.13 PIK35084.1 - 0.052 13.4 1.8 1.4 8.8 1.8 2.1 1 1 0 1 1 1 0 Serine hydrolase Abhydrolase_1 PF00561.20 PIK35084.1 - 0.062 12.9 0.9 0.25 10.9 0.9 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 PIK35084.1 - 0.062 13.1 0.2 5 6.9 0.0 2.1 1 1 0 2 2 2 0 Phospholipase/Carboxylesterase Smr PF01713.21 PIK35084.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Smr domain Lipase_2 PF01674.18 PIK35084.1 - 0.12 11.9 0.1 0.12 11.9 0.1 1.5 2 0 0 2 2 2 0 Lipase (class 2) Cas9-BH PF16593.5 PIK35084.1 - 2.2 8.1 5.4 4.4 7.1 5.4 1.4 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 VCBS PF13517.6 PIK35085.1 - 2.1e-07 31.4 2.4 0.0052 17.4 0.7 2.6 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK35085.1 - 1.6e-06 28.2 1.1 0.07 13.3 0.2 2.5 2 0 0 2 2 2 2 FG-GAP repeat PliI PF16743.5 PIK35085.1 - 0.011 15.4 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Periplasmic lysozyme inhibitor of I-type lysozyme Ninjurin PF04923.12 PIK35086.1 - 1.1e-11 44.5 1.2 2.1e-11 43.7 1.2 1.4 1 1 0 1 1 1 1 Ninjurin Vpu PF00558.19 PIK35086.1 - 0.043 13.6 0.6 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Vpu protein CUB PF00431.20 PIK35087.1 - 4.5e-17 62.4 0.0 6.8e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 CUB domain Ldl_recept_b PF00058.17 PIK35087.1 - 0.00016 22.0 0.1 0.00047 20.6 0.1 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor repeat class B SQS_PSY PF00494.19 PIK35088.1 - 2.2e-63 214.2 0.6 2.5e-63 214.0 0.6 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase Glyco_hydro_47 PF01532.20 PIK35089.1 - 4.2e-100 335.8 0.0 5.3e-100 335.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CREPT PF16566.5 PIK35090.1 - 3.1e-41 141.0 3.6 3.1e-41 141.0 3.6 2.6 2 2 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 PIK35090.1 - 1.4e-14 54.6 1.6 2.8e-14 53.7 0.2 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Ran-binding PF05508.11 PIK35090.1 - 0.0037 16.3 1.9 0.0071 15.4 1.9 1.4 1 0 0 1 1 1 1 RanGTP-binding protein L27_1 PF09058.10 PIK35090.1 - 0.089 12.8 5.1 0.3 11.1 2.7 2.8 1 1 1 2 2 2 0 L27_1 YrbL-PhoP_reg PF10707.9 PIK35090.1 - 0.13 11.7 2.2 0.99 8.9 0.3 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL ApoL PF05461.11 PIK35090.1 - 0.33 10.2 4.5 0.58 9.4 4.5 1.3 1 0 0 1 1 1 0 Apolipoprotein L CTK3 PF12243.8 PIK35090.1 - 0.67 10.0 2.9 0.44 10.6 0.3 1.9 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 BLOC1_2 PF10046.9 PIK35090.1 - 1.3 9.3 10.0 0.5 10.7 6.0 2.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pinin_SDK_N PF04697.13 PIK35090.1 - 3 8.5 7.2 3.7 8.2 0.9 2.4 2 0 0 2 2 2 0 pinin/SDK conserved region TMPIT PF07851.13 PIK35090.1 - 7.6 5.7 7.9 0.96 8.6 2.2 2.0 2 0 0 2 2 2 0 TMPIT-like protein Tsg PF04668.12 PIK35091.1 - 3.5e-27 95.7 9.0 3.7e-27 95.6 9.0 1.1 1 0 0 1 1 1 1 Twisted gastrulation (Tsg) protein conserved region Aa_trans PF01490.18 PIK35092.1 - 1.9e-16 59.8 10.8 2.9e-16 59.2 10.8 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 PIK35092.1 - 0.00085 18.5 8.2 0.00085 18.5 8.2 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DUF4134 PF13572.6 PIK35092.1 - 0.012 15.9 0.6 0.024 14.9 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) DUF4267 PF14087.6 PIK35092.1 - 0.018 15.1 0.5 0.034 14.2 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4267) Glyco_transf_21 PF13506.6 PIK35094.1 - 2.6e-40 137.7 0.0 4.5e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 PIK35094.1 - 6.4e-17 62.2 0.0 8.1e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 PIK35094.1 - 3.8e-11 43.3 0.0 7.3e-11 42.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 RVT_1 PF00078.27 PIK35095.1 - 1.7e-25 89.9 0.0 4.5e-25 88.5 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK35095.1 - 0.0016 18.6 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK35095.1 - 0.0037 17.0 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK35096.1 - 1.5e-36 124.4 0.0 5.6e-36 122.6 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35096.1 - 7.3e-25 87.3 0.0 2.4e-24 85.6 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK35096.1 - 1.7e-18 66.5 0.1 2.8e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK35096.1 - 7.1e-16 58.5 0.0 1.3e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK35096.1 - 1.9e-05 24.8 0.0 3.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger MATalpha_HMGbox PF04769.12 PIK35096.1 - 0.039 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box NEAT PF05031.12 PIK35096.1 - 0.11 13.1 0.0 0.19 12.4 0.0 1.3 1 0 0 1 1 1 0 Iron Transport-associated domain rve_3 PF13683.6 PIK35096.1 - 0.19 11.5 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Glycolytic PF00274.19 PIK35097.1 - 1.3e-129 431.9 0.0 1.6e-129 431.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I MASE1 PF05231.14 PIK35098.1 - 0.02 14.0 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 MASE1 C2 PF00168.30 PIK35099.1 - 5.4e-36 123.0 0.6 1.2e-18 67.3 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 PIK35099.1 - 0.019 14.5 0.9 0.43 10.1 0.8 2.4 2 1 0 2 2 2 0 CEP76 C2 domain Pcc1 PF09341.10 PIK35099.1 - 0.096 12.8 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Transcription factor Pcc1 Forkhead PF00250.18 PIK35100.1 - 9.2e-33 112.4 0.0 1.1e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain CaMKII_AD PF08332.10 PIK35102.1 - 0.00036 20.7 0.0 0.00047 20.3 0.0 1.2 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain RRM_1 PF00076.22 PIK35104.1 - 1.3e-30 105.0 0.3 2.4e-10 40.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK35104.1 - 1.9e-06 27.8 0.0 0.12 12.4 0.0 2.8 2 0 0 2 2 2 2 RNA binding motif PHM7_cyt PF14703.6 PIK35104.1 - 0.0041 17.4 0.4 7.9 6.7 0.1 3.9 2 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 PIK35104.1 - 0.014 15.2 0.0 0.19 11.5 0.0 2.6 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain ATP-synt_S1 PF05827.12 PIK35110.1 - 9e-37 126.1 0.8 1.6e-36 125.3 0.8 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Lamp PF01299.17 PIK35110.1 - 2.6e-05 24.1 3.0 4.1e-05 23.5 3.0 1.3 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) NDUF_B12 PF08122.12 PIK35110.1 - 0.12 12.4 0.1 0.37 10.9 0.1 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B12 subunit family Comm PF15957.5 PIK35110.1 - 0.27 11.6 2.0 11 6.4 0.2 2.7 3 0 0 3 3 3 0 Commissureless GCV_T PF01571.21 PIK35111.1 - 6.3e-88 294.5 0.0 7.7e-88 294.2 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 PIK35111.1 - 4.4e-08 32.9 0.0 9.1e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 PIK35111.1 - 0.00011 22.4 0.0 0.00019 21.6 0.0 1.4 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family Hydrolase PF00702.26 PIK35111.1 - 0.055 13.8 0.0 0.15 12.3 0.0 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase COesterase PF00135.28 PIK35112.1 - 2.5e-98 330.2 0.0 3.3e-98 329.8 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK35112.1 - 0.0015 18.5 0.1 0.067 13.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK35113.1 - 9.8e-73 245.8 0.0 1.2e-72 245.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK35114.1 - 4.4e-105 352.5 0.0 5.2e-105 352.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK35114.1 - 2e-05 24.6 0.1 0.02 14.8 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 PIK35114.1 - 0.033 13.1 0.0 0.42 9.5 0.0 2.1 1 1 0 1 1 1 0 Chlorophyllase enzyme DUF4748 PF15932.5 PIK35114.1 - 0.095 12.5 0.4 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) UDPGT PF00201.18 PIK35115.1 - 2.2e-62 211.5 0.1 3.2e-62 210.9 0.1 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK35115.1 - 0.0019 18.2 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain zf-C3HC4 PF00097.25 PIK35116.1 - 4.4e-11 42.5 7.1 4.4e-11 42.5 7.1 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35116.1 - 4.2e-10 39.5 8.9 4.2e-10 39.5 8.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK35116.1 - 3.4e-08 33.2 11.4 3.4e-08 33.2 11.4 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK35116.1 - 9.9e-07 28.5 8.1 9.9e-07 28.5 8.1 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK35116.1 - 1e-06 28.9 7.9 1e-06 28.9 7.9 3.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK35116.1 - 4.5e-06 26.7 10.0 4.5e-06 26.7 10.0 4.0 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK35116.1 - 1.6e-05 24.8 5.8 1.6e-05 24.8 5.8 3.6 3 1 0 3 3 2 1 zinc-RING finger domain zf-B_box PF00643.24 PIK35116.1 - 1.7e-05 24.8 27.3 0.00037 20.6 12.6 4.0 4 0 0 4 4 4 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK35116.1 - 0.016 15.1 10.6 0.016 15.1 10.6 3.5 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 DUF148 PF02520.17 PIK35116.1 - 0.038 14.1 1.1 0.079 13.1 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF2205 PF10224.9 PIK35116.1 - 0.043 13.8 1.5 0.11 12.4 1.5 1.7 1 0 0 1 1 1 0 Short coiled-coil protein US22 PF02393.16 PIK35116.1 - 0.049 13.9 0.6 0.079 13.2 0.6 1.4 1 0 0 1 1 1 0 US22 like DUF4407 PF14362.6 PIK35116.1 - 0.13 11.5 0.2 0.17 11.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 PIK35116.1 - 0.15 12.5 2.9 0.35 11.4 2.9 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Gon7 PF08738.10 PIK35116.1 - 0.22 11.6 0.8 0.34 11.0 0.2 1.6 2 0 0 2 2 2 0 Gon7 family zf-B_box PF00643.24 PIK35117.1 - 0.00057 20.0 13.6 0.00084 19.4 13.6 1.2 1 0 0 1 1 1 1 B-box zinc finger UPF0242 PF06785.11 PIK35117.1 - 0.0022 18.2 6.0 0.0027 17.8 6.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Muted PF14942.6 PIK35117.1 - 0.012 16.0 14.6 0.018 15.4 14.6 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Tiam_CC_Ex PF18385.1 PIK35117.1 - 0.067 13.6 2.5 0.1 13.0 1.8 1.6 1 1 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain Tmemb_9 PF05434.11 PIK35117.1 - 0.069 13.0 4.8 0.037 13.9 2.6 1.7 1 1 1 2 2 2 0 TMEM9 KxDL PF10241.9 PIK35117.1 - 1.1 9.6 10.4 1.4 9.3 6.6 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein RPN2_C PF18004.1 PIK35117.1 - 1.7 8.5 11.3 1.3 8.9 10.1 1.4 1 1 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RP-C_C PF11800.8 PIK35117.1 - 3.8 7.6 6.5 6.7 6.7 6.5 1.4 1 1 0 1 1 1 0 Replication protein C C-terminal region YtxH PF12732.7 PIK35117.1 - 5.4 7.6 10.0 1.2e+03 0.1 10.0 2.6 1 1 0 1 1 1 0 YtxH-like protein V-ATPase_G PF03179.15 PIK35117.1 - 6.2 7.4 16.7 8.1 7.0 11.6 2.2 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF334 PF03904.13 PIK35117.1 - 8.6 5.8 13.2 20 4.7 12.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF334) Laminin_EGF PF00053.24 PIK35119.1 - 0.12 12.6 27.5 0.82 9.9 4.0 3.8 2 1 0 3 3 3 0 Laminin EGF domain NDUF_B8 PF05821.11 PIK35120.1 - 6.9e-47 159.6 4.6 8e-47 159.4 4.6 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DUF5630 PF18632.1 PIK35121.1 - 0.15 11.4 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5630) Peptidase_A17 PF05380.13 PIK35122.1 - 7.7e-41 139.8 0.0 1.1e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK35123.1 - 4.7e-05 23.4 0.5 0.00014 21.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) HTH_57 PF18679.1 PIK35123.1 - 0.098 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 ThcOx helix turn helix domain NUDE_C PF04880.13 PIK35123.1 - 0.49 10.9 7.7 0.2 12.1 5.2 1.6 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region RVT_1 PF00078.27 PIK35124.1 - 2.8e-18 66.3 0.1 9.6e-18 64.5 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK35125.1 - 4.5e-22 77.9 0.3 7.7e-22 77.2 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK35125.1 - 4.1e-19 68.9 0.0 8.7e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK35125.1 - 2.2e-07 31.0 0.0 4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK35125.1 - 0.0034 17.1 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK35125.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 DDE domain DUF3091 PF11291.8 PIK35128.1 - 0.046 13.9 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) Ank_3 PF13606.6 PIK35128.1 - 0.15 12.7 0.0 0.82 10.4 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat ABC_membrane_2 PF06472.15 PIK35129.1 - 2.7e-86 289.3 6.6 3.4e-86 289.0 6.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 PIK35129.1 - 6.8e-18 65.5 0.0 1.6e-17 64.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK35129.1 - 0.00028 20.4 0.1 0.24 10.8 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 PIK35129.1 - 0.0028 17.3 2.1 0.0042 16.8 2.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_23 PF13476.6 PIK35129.1 - 0.0034 17.9 0.0 0.0087 16.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 PIK35129.1 - 0.0065 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK35129.1 - 0.039 13.7 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 PIK35129.1 - 0.073 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 PIK35129.1 - 0.15 12.6 0.0 0.37 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK35129.1 - 0.18 12.1 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 PIK35130.1 - 2.1e-14 53.6 0.0 3.4e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK35130.1 - 6.2e-07 29.1 0.1 4e-06 26.4 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK35130.1 - 1.9e-05 24.7 0.0 0.0069 16.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 PIK35130.1 - 0.0034 16.7 0.3 0.0079 15.6 0.2 1.6 1 1 0 1 1 1 1 AIG1 family IIGP PF05049.13 PIK35130.1 - 0.0058 15.7 0.1 0.011 14.9 0.0 1.4 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) G-alpha PF00503.20 PIK35130.1 - 0.026 13.7 0.1 0.15 11.2 0.0 2.0 1 1 0 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 PIK35130.1 - 0.045 14.3 0.0 0.084 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 PIK35130.1 - 0.048 13.4 0.0 8.4 6.1 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 PIK35130.1 - 0.098 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK35130.1 - 0.1 12.2 0.0 4 7.0 0.0 2.3 2 0 0 2 2 2 0 Ras family AAA_29 PF13555.6 PIK35130.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 PIK35130.1 - 0.14 12.2 0.4 2.5 8.2 0.1 2.3 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.6 PIK35130.1 - 0.15 12.3 0.0 0.3 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF16 PF01519.16 PIK35131.1 - 0.0028 18.1 3.9 0.0028 18.1 3.9 2.6 3 0 0 3 3 2 1 Protein of unknown function DUF16 MPS2 PF17060.5 PIK35131.1 - 0.0042 16.4 4.3 0.0075 15.6 4.3 1.5 1 0 0 1 1 1 1 Monopolar spindle protein 2 TACC_C PF05010.14 PIK35131.1 - 0.0045 16.8 16.3 0.018 14.9 7.1 2.4 1 1 1 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Phage_Mu_Gam PF07352.12 PIK35131.1 - 0.012 15.6 8.6 0.16 11.9 2.2 2.8 2 1 0 2 2 2 0 Bacteriophage Mu Gam like protein EVC2_like PF12297.8 PIK35131.1 - 0.022 13.5 11.5 0.035 12.8 0.1 2.4 2 1 0 2 2 2 0 Ellis van Creveld protein 2 like protein FliJ PF02050.16 PIK35131.1 - 0.041 14.1 16.9 0.21 11.8 1.2 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein CC2-LZ PF16516.5 PIK35131.1 - 0.13 12.7 8.6 0.7 10.3 1.5 2.7 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FAM184 PF15665.5 PIK35131.1 - 0.2 11.4 23.3 29 4.4 23.3 3.0 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B DUF812 PF05667.11 PIK35131.1 - 0.29 10.0 17.3 0.1 11.5 4.9 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 PIK35131.1 - 0.45 9.8 11.6 1.8 7.8 2.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ERM PF00769.19 PIK35131.1 - 0.6 9.9 18.1 11 5.7 7.9 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 PIK35131.1 - 1.1 9.4 4.9 5.9 7.0 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Hemagglutinin PF00509.18 PIK35131.1 - 1.2 7.4 4.7 6.5 5.0 0.8 2.1 2 0 0 2 2 2 0 Haemagglutinin BLOC1_2 PF10046.9 PIK35131.1 - 3 8.2 6.9 4.8 7.6 1.9 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.6 PIK35131.1 - 3.4 7.0 21.2 0.31 10.4 1.8 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 PIK35131.1 - 4.1 8.1 9.1 4.5 8.0 0.8 3.6 2 2 1 3 3 3 0 SlyX Prefoldin PF02996.17 PIK35131.1 - 5 7.1 9.7 2.7 7.9 0.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit OEP PF02321.18 PIK35131.1 - 6.7 6.5 7.0 0.64 9.8 2.5 1.5 2 0 0 2 2 1 0 Outer membrane efflux protein TMPIT PF07851.13 PIK35131.1 - 7.2 5.8 12.5 0.72 9.0 4.6 2.1 1 1 1 2 2 2 0 TMPIT-like protein Exonuc_VII_L PF02601.15 PIK35131.1 - 7.2 6.1 15.6 61 3.0 15.6 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 PIK35131.1 - 7.9 5.8 17.7 0.8 9.1 9.5 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Seryl_tRNA_N PF02403.22 PIK35131.1 - 8.1 6.7 10.0 1 9.6 1.4 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain LRR_8 PF13855.6 PIK35132.1 - 2.9e-50 167.8 56.5 3.5e-12 45.9 0.2 7.3 4 1 4 8 8 8 7 Leucine rich repeat LRR_5 PF13306.6 PIK35132.1 - 8.8e-26 90.4 11.7 1.3e-10 41.3 0.1 3.9 2 2 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK35132.1 - 2.2e-25 88.3 40.3 4.5e-05 23.7 1.2 9.0 6 1 4 10 10 10 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK35132.1 - 8.2e-11 41.7 18.3 0.0046 16.5 0.3 4.2 1 1 2 4 4 4 4 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK35132.1 - 0.0012 18.6 21.2 0.011 15.5 2.7 3.3 2 1 1 3 3 3 2 Putative ephrin-receptor like LRR_1 PF00560.33 PIK35132.1 - 0.71 10.7 34.9 7.2 7.6 0.1 9.4 10 2 0 10 10 10 0 Leucine Rich Repeat TNFR_c6 PF00020.18 PIK35132.1 - 1.3 9.5 14.5 1.8 9.1 0.0 3.9 1 1 3 4 4 4 0 TNFR/NGFR cysteine-rich region LRR_6 PF13516.6 PIK35132.1 - 4.6 7.6 27.2 1.2 9.3 0.3 7.7 9 0 0 9 9 9 0 Leucine Rich repeat Rad10 PF03834.14 PIK35134.1 - 0.047 13.7 0.2 0.11 12.5 0.2 1.6 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) PSD4 PF07631.11 PIK35135.1 - 0.62 10.6 2.5 5.6 7.5 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1592) PRMT5_C PF17286.2 PIK35136.1 - 1.5e-48 165.0 0.1 1.9e-48 164.6 0.1 1.1 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 PIK35136.1 - 2.3e-07 30.8 0.1 5.8e-07 29.5 0.1 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 PIK35137.1 - 1.3e-72 244.1 0.0 1.6e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 PIK35137.1 - 6.9e-40 136.7 0.2 1.1e-39 136.1 0.2 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Acetyltransf_2 PF00797.17 PIK35139.1 - 3.2e-10 40.2 0.0 4.7e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase Neurexophilin PF06312.12 PIK35140.1 - 8.6e-07 28.6 0.0 2.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Neurexophilin PC-Esterase PF13839.6 PIK35140.1 - 0.011 15.5 0.0 0.59 9.8 0.1 2.3 2 0 0 2 2 2 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Invasin_D3 PF09134.10 PIK35140.1 - 0.046 14.0 0.2 0.13 12.5 0.2 1.7 1 0 0 1 1 1 0 Invasin, domain 3 Bac_GH3_C PF18034.1 PIK35140.1 - 0.072 12.8 0.1 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain Filamin PF00630.19 PIK35140.1 - 0.12 13.3 0.1 0.27 12.1 0.1 1.6 1 1 0 1 1 1 0 Filamin/ABP280 repeat Lipase_GDSL_2 PF13472.6 PIK35140.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Neur_chan_LBD PF02931.23 PIK35141.1 - 1.8e-12 47.2 0.1 1.8e-12 47.1 0.1 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Aminotran_1_2 PF00155.21 PIK35143.1 - 3.5e-90 302.8 0.0 4e-90 302.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II fn3 PF00041.21 PIK35144.1 - 4.6e-46 155.1 4.7 4.6e-15 55.7 0.3 5.3 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK35144.1 - 3.4e-07 30.8 8.9 0.084 13.5 0.2 5.0 5 1 1 6 6 6 3 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK35144.1 - 0.00028 21.0 0.1 0.19 11.9 0.0 3.5 3 0 0 3 3 3 1 Fibronectin type III domain Interfer-bind PF09294.10 PIK35144.1 - 0.0038 17.5 0.0 13 6.1 0.0 3.8 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.6 PIK35144.1 - 0.2 11.9 2.0 2.1 8.6 0.0 3.1 2 1 0 3 3 3 0 SusE outer membrane protein SprB PF13573.6 PIK35144.1 - 0.65 9.8 5.2 0.37 10.6 0.4 2.6 2 0 0 2 2 2 0 SprB repeat RVT_1 PF00078.27 PIK35145.1 - 1.5e-44 152.2 0.0 2.1e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FXa_inhibition PF14670.6 PIK35146.1 - 6.9e-14 51.8 27.9 3.9e-09 36.6 9.1 6.7 3 1 3 6 6 6 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK35146.1 - 1.7e-07 31.3 9.5 1.7e-07 31.3 9.5 7.1 3 2 2 5 5 5 1 Calcium-binding EGF domain EGF PF00008.27 PIK35146.1 - 2.7e-07 30.8 93.7 0.012 15.9 12.8 7.2 5 1 0 6 6 6 5 EGF-like domain EGF_2 PF07974.13 PIK35146.1 - 1.7e-06 28.3 95.6 0.0022 18.3 9.3 7.0 5 1 1 6 6 6 4 EGF-like domain EGF_3 PF12947.7 PIK35146.1 - 0.00046 20.3 4.8 0.00046 20.3 4.8 6.8 5 1 1 6 6 6 2 EGF domain hEGF PF12661.7 PIK35146.1 - 0.022 15.4 21.0 0.038 14.6 6.6 9.2 10 1 0 10 10 10 0 Human growth factor-like EGF DUF4870 PF09685.10 PIK35146.1 - 0.023 14.8 1.5 0.034 14.3 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) cEGF PF12662.7 PIK35146.1 - 0.039 13.9 2.3 0.039 13.9 2.3 8.0 7 2 0 7 7 7 0 Complement Clr-like EGF-like ZU5 PF00791.20 PIK35148.1 - 4.7e-09 36.5 0.4 1.3e-08 35.0 0.1 1.9 2 0 0 2 2 2 1 ZU5 domain bPH_5 PF10882.8 PIK35148.1 - 0.0064 16.5 0.3 4.7 7.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial PH domain ZU5 PF00791.20 PIK35149.1 - 3.8e-10 40.0 0.0 1.3e-09 38.3 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain GAS PF13851.6 PIK35150.1 - 1.2e-11 44.3 101.6 0.00015 21.2 32.1 4.2 1 1 3 4 4 4 4 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK35150.1 - 2.2e-10 40.8 116.2 0.00053 19.9 38.0 3.7 1 1 3 4 4 4 4 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK35150.1 - 2e-08 34.8 121.8 0.29 11.6 22.3 5.0 1 1 2 3 3 2 2 Apg6 coiled-coil region KASH_CCD PF14662.6 PIK35150.1 - 4.2e-07 30.0 106.2 0.032 14.1 16.6 5.5 1 1 4 5 5 5 5 Coiled-coil region of CCDC155 or KASH DUF4472 PF14739.6 PIK35150.1 - 0.00023 21.9 90.4 0.2 12.4 18.4 5.8 1 1 5 6 6 6 5 Domain of unknown function (DUF4472) Lebercilin PF15619.6 PIK35150.1 - 0.00027 20.6 104.4 0.013 15.2 15.1 5.6 1 1 5 6 6 6 3 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 PIK35150.1 - 0.00074 20.1 113.1 0.88 10.2 22.0 5.4 1 1 5 6 6 6 5 Clathrin-binding domain of Huntingtin-interacting protein 1 Cep57_MT_bd PF06657.13 PIK35150.1 - 0.038 14.4 72.1 0.33 11.4 7.6 7.3 1 1 8 9 9 9 0 Centrosome microtubule-binding domain of Cep57 HBM PF16591.5 PIK35150.1 - 0.051 13.0 70.2 1.1 8.7 14.1 4.5 1 1 3 4 4 4 0 Helical bimodular sensor domain Fez1 PF06818.15 PIK35150.1 - 0.12 12.8 97.9 5.4 7.4 13.2 3.6 1 1 2 3 3 3 0 Fez1 DUF1495 PF07381.11 PIK35150.1 - 0.18 11.7 4.0 18 5.3 0.0 4.6 2 1 4 7 7 7 0 Winged helix DNA-binding domain (DUF1495) DUF1664 PF07889.12 PIK35150.1 - 0.67 10.0 56.8 5 7.2 10.5 4.6 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4600 PF15372.6 PIK35150.1 - 0.72 10.3 79.7 9.2 6.7 1.5 7.9 1 1 6 7 7 7 0 Domain of unknown function (DUF4600) SBD PF17882.1 PIK35150.1 - 1 9.2 3.2 45 3.9 0.0 3.9 1 1 1 4 4 4 0 OAA-family lectin sugar binding domain bZIP_1 PF00170.21 PIK35150.1 - 3.3 7.9 83.0 1.5 8.9 5.8 8.1 3 2 4 7 7 7 0 bZIP transcription factor FmiP_Thoc5 PF09766.9 PIK35150.1 - 7.9 5.7 94.9 3 7.0 23.1 4.2 1 1 3 4 4 4 0 Fms-interacting protein/Thoc5 RVT_1 PF00078.27 PIK35151.1 - 1e-36 126.5 0.1 1.4e-36 126.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 PIK35153.1 - 1.1e-34 120.0 0.0 1.3e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35153.1 - 3.3e-21 75.7 0.0 5.4e-21 75.0 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK35153.1 - 5.6e-07 29.2 0.0 6.7e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 PIK35153.1 - 0.00034 19.8 0.2 0.00047 19.3 0.2 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 PIK35153.1 - 0.02 13.8 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 PIK35153.1 - 0.026 13.3 0.0 0.051 12.4 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 PIK35153.1 - 0.046 13.6 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family SepQ PF06622.11 PIK35153.1 - 0.092 11.8 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 SepQ protein Choline_kinase PF01633.20 PIK35153.1 - 0.14 11.7 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase zf-HC5HC2H_2 PF13832.6 PIK35154.1 - 0.17 12.1 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain Abhydrolase_1 PF00561.20 PIK35155.1 - 1.6e-08 34.5 0.0 1.8e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 PIK35155.1 - 7.4e-05 22.8 0.0 8.1e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 PIK35155.1 - 0.0015 17.9 0.0 0.0015 17.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 PIK35155.1 - 0.0032 17.0 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 PIK35155.1 - 0.035 13.8 0.1 0.041 13.5 0.1 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 PIK35155.1 - 0.1 12.2 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family zf-C2H2 PF00096.26 PIK35156.1 - 1.5e-22 78.7 32.3 2.4e-05 24.5 1.2 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35156.1 - 2.8e-17 61.9 31.9 0.0017 19.0 1.4 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK35156.1 - 8.4e-14 51.3 36.0 1e-05 25.7 0.3 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK35156.1 - 1.4e-07 31.6 27.9 0.00051 20.3 0.1 5.7 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK35156.1 - 0.0086 16.4 29.4 0.035 14.5 0.7 5.7 6 0 0 6 6 6 2 Zinc-finger of C2H2 type Sprouty PF05210.13 PIK35156.1 - 0.026 14.9 2.8 0.026 14.9 2.8 2.7 2 1 0 2 2 2 0 Sprouty protein (Spry) zinc_ribbon_15 PF17032.5 PIK35156.1 - 0.13 13.1 0.8 0.13 13.1 0.8 3.1 2 1 0 2 2 1 0 zinc-ribbon family zf-C2H2_2 PF12756.7 PIK35156.1 - 0.15 12.4 18.2 1.1 9.6 0.7 4.2 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 PIK35156.1 - 0.18 12.3 0.6 0.18 12.3 0.6 4.8 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK35156.1 - 0.19 11.7 23.2 0.42 10.7 0.4 4.8 3 1 2 5 5 5 0 BED zinc finger Elf1 PF05129.13 PIK35156.1 - 0.22 11.6 19.8 1.2 9.3 4.8 3.3 2 1 0 3 3 3 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 PIK35156.1 - 1 9.6 31.1 1.4 9.1 2.2 5.5 4 1 1 5 5 5 0 AN1-like Zinc finger zf-C2H2_11 PF16622.5 PIK35156.1 - 2.2 8.1 28.8 4.9 7.0 0.3 5.3 5 0 0 5 5 5 0 zinc-finger C2H2-type PyrI_C PF02748.15 PIK35156.1 - 2.9 7.9 16.4 17 5.4 1.1 4.8 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-LYAR PF08790.11 PIK35156.1 - 4.3 7.3 13.7 0.89 9.5 0.1 4.1 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 PIK35156.1 - 8.5 6.6 21.2 3.9 7.7 0.6 4.5 3 1 2 5 5 5 0 Zinc ribbon domain DM13 PF10517.9 PIK35158.1 - 3.4e-13 50.1 0.0 3.2e-07 30.9 0.0 2.9 2 1 0 2 2 2 2 Electron transfer DM13 Forkhead PF00250.18 PIK35159.1 - 2.1e-29 101.6 0.1 3.7e-29 100.8 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Ank PF00023.30 PIK35160.1 - 1.2e-32 110.9 7.8 1.1e-05 25.6 0.1 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_2 PF12796.7 PIK35160.1 - 6.9e-32 109.9 4.6 2.2e-17 63.4 1.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK35160.1 - 4e-29 97.4 3.3 0.00011 22.4 0.0 5.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK35160.1 - 8.6e-29 99.2 6.0 1.6e-12 47.3 0.1 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK35160.1 - 4.4e-28 97.3 9.3 8e-09 35.9 0.2 5.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Thymosin PF01290.20 PIK35160.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 Thymosin beta-4 family FliT PF05400.13 PIK35160.1 - 0.2 12.5 1.5 5.2 8.0 0.0 3.3 3 1 1 4 4 4 0 Flagellar protein FliT ANAPC8 PF04049.13 PIK35160.1 - 0.25 11.4 1.9 3.8 7.6 0.2 2.5 2 0 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 VPS9 PF02204.18 PIK35161.1 - 6.8e-16 58.4 0.0 1.2e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 PIK35161.1 - 2.8e-08 33.8 0.4 4.3e-05 23.7 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK35161.1 - 2.7e-07 31.1 0.0 5.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK35161.1 - 0.0001 22.4 0.0 0.49 11.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 PIK35161.1 - 0.00014 22.4 0.1 0.00053 20.5 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK35161.1 - 0.00018 21.8 0.1 0.5 10.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat fn3 PF00041.21 PIK35162.1 - 5.1e-14 52.4 2.3 2.1e-10 40.8 0.6 2.9 2 2 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK35162.1 - 0.00013 22.5 3.0 0.0013 19.3 2.5 2.4 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF4484 PF14831.6 PIK35163.1 - 0.0009 19.3 0.6 0.0009 19.3 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) fn3 PF00041.21 PIK35163.1 - 0.0018 18.6 0.1 0.0036 17.6 0.1 1.5 1 1 0 1 1 1 1 Fibronectin type III domain PPP4R2 PF09184.11 PIK35163.1 - 0.026 14.1 3.3 0.031 13.9 3.3 1.2 1 0 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 PIK35163.1 - 0.082 12.9 3.4 0.13 12.3 3.4 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 PIK35163.1 - 0.14 11.5 16.6 0.18 11.1 16.6 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 PIK35163.1 - 0.18 10.1 5.8 0.21 9.8 5.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 PIK35163.1 - 0.32 10.9 4.7 0.4 10.5 4.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region fn3 PF00041.21 PIK35164.1 - 1.3e-15 57.5 0.6 1.4e-07 31.7 0.2 3.4 3 1 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK35164.1 - 0.12 13.0 0.3 2.1 9.0 0.4 2.7 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 PIK35165.1 - 1.4e-27 95.8 6.9 6e-13 48.9 0.1 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK35165.1 - 4.7e-09 36.7 8.1 0.00078 20.0 0.1 3.3 3 0 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 PIK35165.1 - 0.012 15.6 0.1 0.055 13.4 0.1 2.2 1 0 0 1 1 1 0 Y_Y_Y domain DUF2369 PF10179.9 PIK35165.1 - 0.048 14.0 0.0 0.31 11.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) GPI-anchored PF10342.9 PIK35165.1 - 0.18 12.6 5.9 1.9 9.3 0.1 3.5 1 1 2 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family COesterase PF00135.28 PIK35166.1 - 2.1e-20 73.1 0.0 2.3e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK35167.1 - 7.9e-130 434.1 0.0 8.9e-130 433.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK35167.1 - 4.5e-08 33.2 0.0 2.7e-07 30.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK35168.1 - 9e-129 430.6 0.0 1.1e-128 430.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK35168.1 - 2e-07 31.1 0.1 8.8e-07 29.0 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold LRR_8 PF13855.6 PIK35169.1 - 1e-45 153.3 38.9 1.3e-14 53.7 5.7 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK35169.1 - 1.7e-20 72.8 34.8 1.4e-06 28.5 2.0 3.4 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK35169.1 - 1.3e-10 41.4 0.1 2.2e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK35169.1 - 6.3e-07 29.1 14.4 2.7 8.9 0.0 6.0 5 1 0 5 5 5 4 Leucine Rich Repeat LRR_9 PF14580.6 PIK35169.1 - 0.00097 18.7 0.4 0.26 10.8 0.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK35169.1 - 0.023 14.7 11.7 5.1 7.4 0.0 5.4 5 0 0 5 5 5 0 Leucine Rich repeat Fibrinogen_C PF00147.18 PIK35170.1 - 1.9e-54 184.8 4.1 2.4e-54 184.5 4.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Pkinase_Tyr PF07714.17 PIK35171.1 - 1.2e-08 34.6 0.2 4.1e-07 29.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK35171.1 - 0.0023 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK35172.1 - 1.4e-07 31.7 0.4 2.6e-06 27.5 0.0 2.8 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK35172.1 - 6.6e-07 29.8 1.4 0.009 16.6 0.0 3.7 2 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK35172.1 - 1.3e-06 28.4 0.1 0.0063 16.6 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK35172.1 - 6.8e-05 23.0 0.0 0.14 12.3 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain DUF108 PF01958.18 PIK35172.1 - 0.064 13.6 0.0 1.2 9.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF108 Pkinase_Tyr PF07714.17 PIK35173.1 - 9.8e-24 84.0 0.0 1e-23 83.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35173.1 - 1.2e-09 37.9 0.0 1.4e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain ArgoN PF16486.5 PIK35174.1 - 0.00013 22.6 0.0 0.00023 21.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 PIK35174.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Argonaute linker 1 domain GAGE PF05831.11 PIK35174.1 - 1.2 9.7 11.6 0.57 10.7 9.3 1.7 2 0 0 2 2 2 0 GAGE protein RUN PF02759.19 PIK35175.1 - 1.9e-20 73.2 0.0 3.7e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 RUN domain PH_RBD PF12068.8 PIK35175.1 - 1.2e-12 47.7 0.0 1.9e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Rab-binding domain (RBD) RabGAP-TBC PF00566.18 PIK35177.1 - 2e-29 102.8 4.1 3e-29 102.2 4.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-met PF12874.7 PIK35178.1 - 1.1e-14 54.2 4.4 6.6e-08 32.7 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK35178.1 - 7.4e-06 26.1 2.8 0.00033 20.8 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK35178.1 - 5.6e-05 23.4 3.2 0.076 13.3 0.3 2.3 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 PIK35178.1 - 0.0022 17.7 2.3 0.44 10.3 0.0 2.4 2 0 0 2 2 2 2 U1 zinc finger AKAP95 PF04988.12 PIK35178.1 - 0.0071 16.6 2.4 0.32 11.2 0.2 2.3 2 1 0 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) Helicase_C PF00271.31 PIK35179.1 - 1.9e-16 60.4 0.0 4.8e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK35179.1 - 2.5e-07 30.6 0.0 5.4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.23 PIK35179.1 - 1.2e-06 28.8 0.0 2.9e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_19 PF13245.6 PIK35179.1 - 0.0023 18.3 0.0 0.0074 16.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 PIK35179.1 - 0.003 16.6 1.2 0.083 11.9 0.0 2.9 2 1 1 3 3 3 1 Type II/IV secretion system protein PhoH PF02562.16 PIK35179.1 - 0.01 15.3 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein cobW PF02492.19 PIK35179.1 - 0.015 14.9 0.1 2.2 7.8 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 PIK35179.1 - 0.016 15.5 1.6 0.045 14.0 0.3 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK35179.1 - 0.018 15.0 0.1 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 PIK35179.1 - 0.029 13.9 0.0 0.09 12.3 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region dsrm PF00035.26 PIK35179.1 - 0.029 15.1 0.1 0.11 13.2 0.0 2.1 2 0 0 2 2 2 0 Double-stranded RNA binding motif IstB_IS21 PF01695.17 PIK35179.1 - 0.034 13.9 0.0 8.8 6.0 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 PIK35179.1 - 0.057 13.3 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATPase PF06745.13 PIK35179.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 PIK35179.1 - 0.1 12.6 0.0 9.2 6.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 PIK35179.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain BTB_2 PF02214.22 PIK35180.1 - 4.4e-39 132.7 2.4 3.5e-18 65.7 0.0 3.1 3 0 0 3 3 3 3 BTB/POZ domain BTB_3 PF16017.5 PIK35180.1 - 9.8e-12 44.9 0.0 9.8e-05 22.4 0.0 3.1 3 0 0 3 3 3 3 BTB/POZ domain BTB PF00651.31 PIK35180.1 - 2.6e-08 34.1 0.2 0.0061 16.8 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain LytTR PF04397.15 PIK35180.1 - 0.00019 21.6 1.4 0.71 10.1 0.2 3.3 2 2 0 2 2 2 2 LytTr DNA-binding domain DUF4110 PF13422.6 PIK35180.1 - 0.0032 17.5 0.0 2.3 8.3 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4110) FtsQ PF03799.15 PIK35180.1 - 0.0044 17.8 0.0 2.2 9.2 0.0 2.3 2 0 0 2 2 2 2 Cell division protein FtsQ Regulator_TrmB PF11495.8 PIK35180.1 - 0.019 14.1 0.0 1.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB LigA PF07746.11 PIK35180.1 - 0.088 13.0 0.0 22 5.3 0.0 2.5 2 0 0 2 2 2 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit DUF5131 PF07505.11 PIK35180.1 - 0.095 12.1 0.0 3.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) Reprolysin_3 PF13582.6 PIK35180.1 - 0.22 12.1 0.0 23 5.5 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like OB_NTP_bind PF07717.16 PIK35181.1 - 2.9e-06 27.5 0.1 5e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Pkinase PF00069.25 PIK35182.1 - 2.8e-74 249.8 0.0 5.3e-74 248.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35182.1 - 2.4e-35 122.1 0.0 5.2e-35 121.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DCX PF03607.17 PIK35182.1 - 2.7e-05 24.2 0.0 9.4e-05 22.4 0.0 1.9 1 0 0 1 1 1 1 Doublecortin Kinase-like PF14531.6 PIK35182.1 - 0.0004 19.8 0.0 0.00067 19.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK35182.1 - 0.00071 19.0 0.1 0.0014 18.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK35182.1 - 0.0098 14.7 0.0 0.0098 14.7 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 PIK35182.1 - 0.012 15.2 0.1 0.012 15.2 0.1 2.4 4 0 0 4 4 4 0 PhoP regulatory network protein YrbL APH PF01636.23 PIK35182.1 - 0.19 11.6 0.1 1.4 8.7 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family V-set PF07686.17 PIK35183.1 - 0.056 13.6 0.0 0.099 12.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain V-set PF07686.17 PIK35184.1 - 0.0016 18.6 0.1 0.0057 16.8 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK35184.1 - 0.036 14.1 0.3 5.6 7.1 0.1 3.3 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK35184.1 - 0.078 13.6 3.0 12 6.6 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin domain CH PF00307.31 PIK35186.1 - 1.9e-62 208.2 0.0 5.1e-17 62.0 0.0 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 PIK35186.1 - 2.8e-08 32.7 1.0 6.9e-08 31.5 1.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 PIK35186.1 - 1.6e-05 24.7 0.1 4.1e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 PIK35186.1 - 0.00013 22.3 0.2 0.00072 20.0 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 PIK35186.1 - 0.00045 20.0 0.0 0.063 13.1 0.1 2.8 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_6 PF13405.6 PIK35186.1 - 0.0015 18.3 0.1 0.0043 16.9 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 PIK35186.1 - 0.028 13.9 0.4 0.073 12.6 0.4 1.8 1 0 0 1 1 1 0 EF hand Pol_alpha_B_N PF08418.10 PIK35186.1 - 0.19 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal WW_like PF17890.1 PIK35187.1 - 0.02 15.0 0.1 50 4.1 0.0 3.3 3 0 0 3 3 3 0 Peptidoglycan hydrolase LytB WW-like domain zf-C2H2 PF00096.26 PIK35187.1 - 0.97 10.0 14.3 16 6.2 1.7 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35187.1 - 9.7 7.3 15.3 27 5.9 0.5 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger Kinesin PF00225.23 PIK35188.1 - 9.7e-70 235.1 0.2 2e-69 234.1 0.1 1.4 1 1 1 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK35188.1 - 7.7e-24 84.3 0.1 1.4e-23 83.5 0.1 1.4 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 PIK35188.1 - 0.023 13.9 0.3 0.051 12.7 0.3 1.5 1 0 0 1 1 1 0 PIF1-like helicase ISN1 PF06437.11 PIK35189.1 - 0.025 13.5 0.9 0.036 13.0 0.9 1.2 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase EF-hand_4 PF12763.7 PIK35189.1 - 0.064 13.2 1.4 0.22 11.5 1.4 1.9 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand FapA PF03961.13 PIK35189.1 - 0.23 10.0 8.3 0.33 9.5 8.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 PIK35189.1 - 1.8 7.3 17.9 39 3.0 18.0 2.3 1 1 0 1 1 1 0 Spc7 kinetochore protein RRM_1 PF00076.22 PIK35192.1 - 1.1e-18 66.8 0.3 4e-11 42.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK35192.1 - 1.9e-07 31.1 0.3 0.00061 19.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif NCBP3 PF10309.9 PIK35192.1 - 0.017 15.0 0.0 0.24 11.3 0.0 2.6 3 0 0 3 3 3 0 Nuclear cap-binding protein subunit 3 Nup35_RRM_2 PF14605.6 PIK35192.1 - 0.11 12.5 0.1 7 6.7 0.1 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 PIK35192.1 - 0.78 9.8 4.2 14 5.8 0.0 3.2 3 1 0 3 3 3 0 RNA binding motif ANAPC4_WD40 PF12894.7 PIK35193.1 - 1.9e-13 50.5 0.1 1.4e-05 25.3 0.0 4.5 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK35193.1 - 1.8e-12 47.6 11.8 0.00064 20.5 0.0 7.5 8 0 0 8 8 8 3 WD domain, G-beta repeat HELP PF03451.14 PIK35193.1 - 7.4e-12 44.9 0.0 1.4e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 HELP motif Cytochrom_D1 PF02239.16 PIK35193.1 - 0.00016 20.4 0.0 0.089 11.3 0.0 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 PIK35193.1 - 0.0019 17.2 0.2 0.095 11.6 0.0 3.1 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 PIK35194.1 - 0.00052 20.3 0.1 0.0052 17.1 0.1 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PSII_BNR PF14870.6 PIK35194.1 - 0.03 13.6 0.0 0.034 13.4 0.0 1.0 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 eIF2A PF08662.11 PIK35194.1 - 0.034 14.0 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DDE_Tnp_1_7 PF13843.6 PIK35195.1 - 6.2e-23 81.7 0.9 8.5e-23 81.2 0.9 1.1 1 0 0 1 1 1 1 Transposase IS4 NACHT PF05729.12 PIK35196.1 - 4.4e-14 52.7 0.1 1.1e-13 51.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 PIK35196.1 - 0.00029 20.1 0.1 0.00061 19.1 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK35196.1 - 0.0058 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain GlutR_dimer PF00745.20 PIK35196.1 - 0.009 16.4 0.0 0.028 14.9 0.0 1.8 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain ORMDL PF04061.14 PIK35196.1 - 0.044 13.6 0.2 0.18 11.6 0.1 2.0 2 0 0 2 2 2 0 ORMDL family AAA PF00004.29 PIK35196.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ASC PF00858.24 PIK35197.1 - 3.2e-61 207.6 2.8 3.9e-61 207.4 2.8 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel rve PF00665.26 PIK35198.1 - 7.7e-17 61.6 0.0 1.4e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK35198.1 - 0.0032 17.2 0.0 0.012 15.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK35198.1 - 0.014 15.6 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 DDE domain RT_RNaseH_2 PF17919.1 PIK35199.1 - 3.3e-33 113.7 0.1 1.2e-32 111.9 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35199.1 - 2e-29 102.0 0.0 6.2e-29 100.4 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK35199.1 - 2.3e-20 73.1 0.0 5e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK35199.1 - 2.8e-18 65.8 2.1 7.1e-18 64.5 2.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK35199.1 - 0.00035 20.7 0.6 0.001 19.2 0.6 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DUF917 PF06032.12 PIK35200.1 - 2e-76 257.1 2.5 1.7e-48 165.2 0.1 3.2 2 1 1 3 3 3 2 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 PIK35200.1 - 2e-32 112.4 0.1 8.9e-32 110.2 0.0 2.2 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 PIK35200.1 - 2.9e-12 46.4 1.3 0.0097 15.2 0.0 4.3 3 1 1 4 4 4 4 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 PIK35200.1 - 0.13 11.8 0.1 11 5.4 0.0 2.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 PIK35200.1 - 0.17 11.3 0.4 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 ROK family KDGP_aldolase PF07071.11 PIK35200.1 - 2.7 7.8 4.4 3.6 7.3 0.0 2.5 2 1 0 3 3 3 0 KDGP aldolase RVT_1 PF00078.27 PIK35201.1 - 4.5e-33 114.6 0.0 6.8e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK35201.1 - 2.4e-09 37.1 0.1 4.5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK35202.1 - 1.5e-21 76.8 0.0 3.5e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK35202.1 - 1.7e-20 73.3 0.2 5e-20 71.7 0.2 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK35202.1 - 1.9e-19 69.5 0.8 4.2e-19 68.4 0.8 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK35202.1 - 3.9e-10 39.7 0.1 1.2e-09 38.1 0.1 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK35202.1 - 0.01 15.6 0.0 0.032 14.0 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.10 PIK35202.1 - 0.02 15.1 0.1 0.048 13.9 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger DUF5332 PF17266.2 PIK35202.1 - 0.024 14.3 0.8 0.81 9.4 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5332) Fer4_4 PF12800.7 PIK35202.1 - 0.59 10.8 10.0 3.7 8.3 2.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Sushi PF00084.20 PIK35203.1 - 1.7e-27 95.7 51.9 0.00012 22.5 0.1 10.3 10 1 0 10 10 10 9 Sushi repeat (SCR repeat) F5_F8_type_C PF00754.25 PIK35203.1 - 3.6e-06 27.1 0.3 9.3e-06 25.8 0.3 1.7 1 0 0 1 1 1 1 F5/8 type C domain PDE8 PF08629.10 PIK35203.1 - 0.018 15.0 0.7 0.21 11.6 0.0 2.8 3 0 0 3 3 3 0 PDE8 phosphodiesterase Toprim_C_rpt PF13368.6 PIK35203.1 - 0.2 11.6 0.0 0.44 10.6 0.0 1.5 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat 7tm_1 PF00001.21 PIK35204.1 - 1.4e-24 86.8 12.5 2.5e-24 86.0 12.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK35204.1 - 0.00027 20.3 14.7 0.0013 18.0 14.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK35204.1 - 1.2 8.5 13.0 22 4.3 13.0 2.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx ZU5 PF00791.20 PIK35205.1 - 1.7e-10 41.1 0.1 5.7e-10 39.4 0.1 1.9 1 0 0 1 1 1 1 ZU5 domain Bombinin PF05298.11 PIK35205.1 - 0.6 9.8 4.6 3.5 7.3 0.5 2.3 1 1 1 2 2 2 0 Bombinin Glyco_transf_10 PF00852.19 PIK35206.1 - 2.3e-47 161.0 0.2 3.4e-47 160.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK35206.1 - 0.0023 18.4 0.0 0.0042 17.5 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal 7tm_1 PF00001.21 PIK35208.1 - 1.3e-38 132.8 2.0 1.6e-38 132.5 2.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK35208.1 - 2.2e-08 33.8 0.2 2.9e-08 33.4 0.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK35208.1 - 8.6e-08 32.1 2.7 1.2e-07 31.6 2.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK35208.1 - 0.0029 17.2 1.8 0.0038 16.8 1.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 PIK35208.1 - 0.0051 16.6 0.3 0.0067 16.2 0.3 1.1 1 0 0 1 1 1 1 Olfactory receptor Saf_2TM PF18303.1 PIK35208.1 - 0.01 15.4 0.6 0.09 12.4 0.1 2.0 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain 7tm_1 PF00001.21 PIK35209.1 - 9.1e-23 80.9 1.6 1.7e-22 80.0 1.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK35209.1 - 0.0034 16.8 0.1 0.0035 16.7 0.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Acyl-CoA_dh_1 PF00441.24 PIK35210.1 - 1.1e-44 152.3 0.1 1.7e-44 151.7 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK35210.1 - 3e-26 91.4 0.0 5.9e-26 90.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK35210.1 - 9.8e-26 90.6 0.0 2.2e-25 89.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK35210.1 - 1.8e-19 70.3 0.0 3.1e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB PF03241.13 PIK35210.1 - 0.1 11.7 0.1 0.19 10.8 0.1 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Ribosomal_L26 PF16906.5 PIK35211.1 - 2e-40 137.1 5.1 2.7e-40 136.7 5.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 PIK35211.1 - 1e-06 28.5 7.0 1e-06 28.5 7.0 2.4 2 1 0 2 2 2 1 KOW motif Amino_oxidase PF01593.24 PIK35212.1 - 3.8e-09 36.4 1.3 2.6e-08 33.6 0.1 2.4 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK35212.1 - 5.7e-08 32.9 0.0 1.8e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK35212.1 - 9.9e-08 31.9 0.0 3.9e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK35212.1 - 4.8e-07 29.3 0.1 0.0035 16.6 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK35212.1 - 1.5e-06 27.6 4.1 0.0011 18.2 0.3 2.5 3 0 0 3 3 3 2 FAD binding domain Thi4 PF01946.17 PIK35212.1 - 2.8e-06 26.7 0.1 3e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 PIK35212.1 - 5.3e-06 25.9 0.0 2.7e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 PIK35212.1 - 7.3e-06 25.6 0.0 9.9e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK35212.1 - 3.7e-05 23.0 0.0 0.022 13.8 0.0 2.8 3 0 0 3 3 3 2 Glucose inhibited division protein A Pyr_redox PF00070.27 PIK35212.1 - 6.8e-05 23.4 0.1 0.2 12.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 PIK35212.1 - 9.8e-05 21.0 0.0 0.08 11.4 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor HI0933_like PF03486.14 PIK35212.1 - 0.0079 14.9 0.7 0.019 13.7 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 PIK35212.1 - 0.023 13.9 0.4 0.043 13.1 0.4 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pentapeptide_4 PF13599.6 PIK35213.1 - 3e-09 36.9 0.0 4.2e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 PIK35213.1 - 2.6e-07 30.1 0.0 0.0062 16.2 0.0 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) gag-asp_proteas PF13975.6 PIK35213.1 - 0.034 14.7 1.3 1.3 9.6 1.3 2.3 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease PatG_C PF18065.1 PIK35213.1 - 0.49 10.4 3.5 17 5.4 3.5 2.1 1 1 0 1 1 1 0 PatG C-terminal zf-C2H2 PF00096.26 PIK35215.1 - 9.8e-10 38.4 5.1 1e-06 28.9 1.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35215.1 - 2.5e-08 34.0 4.4 0.0002 21.9 0.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK35215.1 - 1.8e-07 31.0 3.0 0.0002 21.2 1.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK35215.1 - 1.6e-05 25.0 0.8 0.035 14.4 0.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK35215.1 - 4.5e-05 23.7 4.7 0.012 16.0 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 PIK35215.1 - 4.5e-05 23.1 1.1 0.022 14.5 0.4 2.4 2 0 0 2 2 2 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 PIK35215.1 - 0.0035 17.4 1.2 0.0084 16.2 1.2 1.6 1 0 0 1 1 1 1 Zinc ribbon domain zf-met PF12874.7 PIK35215.1 - 0.083 13.3 3.3 8.2 7.0 0.6 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK35215.1 - 0.15 12.8 1.2 0.36 11.6 1.2 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-Di19 PF05605.12 PIK35215.1 - 0.46 10.8 3.3 2.5 8.5 3.3 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 PIK35215.1 - 1.3 9.1 5.2 8.7 6.5 1.0 2.7 1 1 1 2 2 2 0 BED zinc finger CpXC PF14353.6 PIK35215.1 - 2.3 8.3 5.1 1.4 9.0 0.2 2.6 2 1 1 3 3 3 0 CpXC protein zf-H2C2_5 PF13909.6 PIK35215.1 - 3 7.7 7.7 12 5.8 0.4 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK35216.1 - 1.5e-25 88.1 33.8 7.4e-06 26.1 0.7 6.3 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35216.1 - 3.2e-20 71.1 31.0 0.00091 19.9 1.6 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK35216.1 - 4e-13 49.1 32.1 3.7e-06 27.1 0.4 6.0 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK35216.1 - 5.3e-12 45.7 11.5 5.8e-05 23.3 0.8 4.9 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK35216.1 - 3.1e-07 30.6 23.3 0.017 15.5 2.8 5.2 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK35216.1 - 4.7e-06 26.8 15.4 0.037 14.3 1.7 3.4 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK35216.1 - 0.0012 18.8 1.7 0.0012 18.8 1.7 5.8 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK35216.1 - 0.0047 17.2 21.6 0.22 11.9 2.6 5.0 1 1 4 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 PIK35216.1 - 0.014 15.8 27.1 0.36 11.3 0.7 5.6 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger Sprouty PF05210.13 PIK35216.1 - 0.018 15.4 1.8 0.018 15.4 1.8 3.1 2 1 0 2 2 2 0 Sprouty protein (Spry) zf-AN1 PF01428.16 PIK35216.1 - 0.058 13.6 24.8 0.4 10.9 0.3 5.4 5 0 0 5 5 5 0 AN1-like Zinc finger zf-C2H2_11 PF16622.5 PIK35216.1 - 0.14 11.9 33.9 0.16 11.8 0.5 5.9 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 PIK35216.1 - 0.29 11.1 25.3 4.7 7.2 0.1 6.0 6 0 0 6 6 6 0 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 PIK35216.1 - 0.35 11.0 19.9 4.4 7.5 1.4 4.8 3 2 0 4 4 4 0 Zinc ribbon domain Elf1 PF05129.13 PIK35216.1 - 0.46 10.6 17.7 2.2 8.4 4.3 3.3 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-HYPF PF07503.12 PIK35216.1 - 0.47 10.3 12.2 4.9 7.0 1.0 4.0 3 1 0 3 3 3 0 HypF finger DUF3565 PF12088.8 PIK35216.1 - 0.73 9.8 7.1 1.6 8.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3565) zf-LYAR PF08790.11 PIK35216.1 - 3.3 7.7 13.3 13 5.7 0.3 4.9 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-BED PF02892.15 PIK35216.1 - 4.4 7.4 29.2 0.25 11.4 1.0 5.4 3 1 2 5 5 5 0 BED zinc finger zinc_ribbon_15 PF17032.5 PIK35216.1 - 5.1 7.9 18.9 0.27 12.0 0.7 3.5 2 1 0 2 2 1 0 zinc-ribbon family Proteasome PF00227.26 PIK35217.1 - 4.2e-33 114.4 0.0 4.6e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Eaf7 PF07904.13 PIK35218.1 - 9.7e-15 54.9 3.2 2.7e-14 53.4 3.2 1.9 1 1 0 1 1 1 1 Chromatin modification-related protein EAF7 Acetyltransf_13 PF13880.6 PIK35220.1 - 7.9e-18 64.2 0.0 1.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 PIK35220.1 - 2.1e-16 59.5 0.2 3.6e-16 58.7 0.2 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Hamartin PF04388.12 PIK35221.1 - 0.65 8.6 5.9 0.69 8.5 5.9 1.0 1 0 0 1 1 1 0 Hamartin protein TMEM154 PF15102.6 PIK35221.1 - 5.6 6.9 0.0 5.6 6.9 0.0 2.5 2 1 0 2 2 2 0 TMEM154 protein family Med3 PF11593.8 PIK35221.1 - 8 5.5 16.1 9.5 5.3 16.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Guanylate_cyc PF00211.20 PIK35222.1 - 3.2e-63 212.6 0.0 6.6e-63 211.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 PIK35222.1 - 7.9e-23 81.1 0.0 2.4e-22 79.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase ANF_receptor PF01094.28 PIK35222.1 - 1.1e-20 74.1 0.2 2.1e-19 69.9 0.0 2.2 1 1 1 2 2 2 1 Receptor family ligand binding region Pkinase PF00069.25 PIK35222.1 - 2.8e-19 69.5 0.0 6.6e-19 68.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 PIK35222.1 - 1.6e-05 24.5 1.1 2.5e-05 23.8 1.1 1.3 1 0 0 1 1 1 1 Heme NO binding associated Spore_III_AB PF09548.10 PIK35222.1 - 0.11 12.6 0.2 3.1 7.9 0.1 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) adh_short PF00106.25 PIK35223.1 - 8.2e-22 77.6 0.1 9.1e-22 77.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK35223.1 - 9.3e-20 71.2 0.1 1.2e-19 70.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK35223.1 - 0.00026 20.9 0.1 0.00033 20.6 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK35224.1 - 1.5e-40 138.8 0.0 1.7e-40 138.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK35224.1 - 2.3e-38 132.1 0.0 2.9e-38 131.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK35224.1 - 4.8e-09 36.4 0.1 6.5e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.13 PIK35224.1 - 0.0044 17.0 0.0 0.0061 16.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family Helicase_RecD PF05127.14 PIK35224.1 - 0.045 13.6 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Helicase YjeF_N PF03853.15 PIK35224.1 - 0.057 13.3 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus 3HCDH_N PF02737.18 PIK35224.1 - 0.087 12.7 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 PIK35224.1 - 0.14 12.0 0.3 0.27 11.0 0.3 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Ras PF00071.22 PIK35225.1 - 2.6e-21 75.9 0.0 3.3e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK35225.1 - 0.0014 18.8 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ada3 PF10198.9 PIK35226.1 - 2e-19 70.1 15.9 2e-19 70.1 15.9 2.9 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 zf-P11 PF03854.14 PIK35227.1 - 0.044 13.4 0.0 0.094 12.4 0.0 1.6 1 0 0 1 1 1 0 P-11 zinc finger RVT_1 PF00078.27 PIK35228.1 - 1.5e-29 103.1 0.0 1.8e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4407 PF14362.6 PIK35229.1 - 0.076 12.4 0.3 0.079 12.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) C2 PF00168.30 PIK35230.1 - 2.1e-13 50.5 0.0 4.9e-09 36.4 0.1 2.3 2 0 0 2 2 2 2 C2 domain LIP1 PF15904.5 PIK35230.1 - 0.021 15.2 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 CEP76-C2 PF15627.6 PIK35230.1 - 0.036 13.6 0.0 2 8.0 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain BBS1 PF14779.6 PIK35231.1 - 3.8e-109 364.0 0.1 2.5e-108 361.3 0.0 2.2 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 1 BBS2_Mid PF14783.6 PIK35231.1 - 4e-14 52.6 0.2 1.4e-06 28.3 0.1 3.4 3 0 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region PHTB1_N PF14727.6 PIK35231.1 - 0.00052 19.5 0.1 0.0058 16.0 0.0 2.6 2 1 1 3 3 3 1 PTHB1 N-terminus TcfC PF16967.5 PIK35231.1 - 0.0011 18.4 0.1 0.37 10.3 0.0 2.5 2 0 0 2 2 2 2 E-set like domain Ald_Xan_dh_C2 PF02738.18 PIK35232.1 - 1.4e-08 33.7 0.0 1.8e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C2 PF02738.18 PIK35233.1 - 1.6e-18 66.5 0.0 1.9e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase DPBB_1 PF03330.18 PIK35233.1 - 0.049 13.9 0.4 0.077 13.3 0.4 1.4 1 1 0 1 1 1 0 Lytic transglycolase Imm72 PF15584.6 PIK35233.1 - 0.056 13.6 0.0 0.074 13.2 0.0 1.3 1 1 0 1 1 1 0 Immunity protein 72 PCM1_C PF15717.5 PIK35234.1 - 0.46 9.1 18.1 0.55 8.9 18.1 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus DUF3698 PF12479.8 PIK35234.1 - 4.7 7.8 5.8 1.7 9.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3698) Kri1_C PF12936.7 PIK35235.1 - 1.6e-15 57.0 0.2 1.6e-15 57.0 0.2 2.3 2 0 0 2 2 2 1 KRI1-like family C-terminal SLC12 PF03522.15 PIK35235.1 - 0.058 12.4 1.5 0.097 11.7 1.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SPT6_acidic PF14632.6 PIK35235.1 - 0.66 10.6 10.9 1 10.0 10.9 1.2 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Kri1 PF05178.12 PIK35236.1 - 3.8e-06 27.4 8.5 3.8e-06 27.4 8.5 4.2 3 1 0 3 3 3 1 KRI1-like family DUF1003 PF06210.11 PIK35236.1 - 2.4 8.3 3.6 5.6 7.1 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Siva PF05458.12 PIK35237.1 - 0.00019 21.1 0.1 0.00028 20.6 0.1 1.2 1 0 0 1 1 1 1 Cd27 binding protein (Siva) zf-H2C2_2 PF13465.6 PIK35238.1 - 5.5e-25 86.6 53.2 7.5e-07 29.3 0.8 8.8 8 1 0 8 8 8 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK35238.1 - 1.3e-17 62.9 55.1 0.0028 18.4 1.8 8.6 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35238.1 - 3.3e-13 49.3 58.1 0.0022 18.3 2.1 8.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 PIK35238.1 - 0.0012 18.5 0.3 0.0012 18.5 0.3 4.5 5 0 0 5 5 4 1 zinc-finger C2H2-type zf-Di19 PF05605.12 PIK35238.1 - 0.0026 18.0 37.1 0.085 13.2 2.7 6.2 4 1 3 7 7 7 2 Drought induced 19 protein (Di19), zinc-binding Sel_put PF04328.13 PIK35238.1 - 0.19 11.8 8.1 0.2 11.7 1.7 2.9 2 0 0 2 2 2 0 Selenoprotein, putative Ribosomal_L28 PF00830.19 PIK35238.1 - 0.22 11.7 14.1 0.068 13.4 1.1 4.2 4 0 0 4 4 4 0 Ribosomal L28 family zf-CHCC PF10276.9 PIK35238.1 - 0.3 11.2 20.6 1.5 9.0 0.3 5.9 6 0 0 6 6 6 0 Zinc-finger domain zinc_ribbon_15 PF17032.5 PIK35238.1 - 0.45 11.3 29.7 21 5.9 7.9 4.5 1 1 2 3 3 3 0 zinc-ribbon family zf-BED PF02892.15 PIK35238.1 - 0.46 10.5 50.3 2.2 8.4 0.3 8.4 3 2 5 8 8 8 0 BED zinc finger zf-C2H2_6 PF13912.6 PIK35238.1 - 0.47 10.5 53.1 0.096 12.7 1.1 8.5 8 0 0 8 8 8 0 C2H2-type zinc finger PRP21_like_P PF12230.8 PIK35238.1 - 0.66 9.8 7.5 15 5.4 0.3 3.2 2 1 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Ashwin PF15323.6 PIK35238.1 - 0.7 9.9 5.7 0.24 11.4 2.5 1.8 1 1 0 1 1 1 0 Developmental protein zf_C2H2_13 PF18508.1 PIK35238.1 - 1.8 8.2 13.4 3.8 7.2 0.3 5.1 4 1 1 5 5 5 0 Zinc finger domain zf-C2HC_2 PF13913.6 PIK35238.1 - 2.2 8.3 31.8 0.32 11.0 0.5 7.3 7 0 0 7 7 7 0 zinc-finger of a C2HC-type Ribosomal_S27e PF01667.17 PIK35238.1 - 3.9 7.3 15.0 6.2 6.6 0.1 4.6 5 0 0 5 5 5 0 Ribosomal protein S27 LUC7 PF03194.15 PIK35238.1 - 4.9 6.7 20.3 8.8e+02 -0.7 20.3 2.8 1 1 0 1 1 1 0 LUC7 N_terminus zf-C2H2_jaz PF12171.8 PIK35238.1 - 5.5 7.4 38.0 4.3 7.7 2.5 7.9 7 1 0 7 7 7 0 Zinc-finger double-stranded RNA-binding FpoO PF10621.9 PIK35238.1 - 5.8 7.3 15.2 1.5 9.1 1.5 3.2 2 1 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO DUF5520 PF17658.1 PIK35239.1 - 0.025 13.7 0.1 0.028 13.6 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) zf-C2H2_4 PF13894.6 PIK35240.1 - 2e-16 59.2 61.5 0.0026 18.5 2.2 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35240.1 - 1.8e-12 47.0 71.4 6.2e-05 23.2 2.5 8.4 8 1 0 8 8 8 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK35240.1 - 1.7e-07 31.3 50.4 0.0024 18.2 2.2 8.5 7 1 0 7 7 7 5 Zinc-finger double domain PyrI_C PF02748.15 PIK35240.1 - 0.015 15.2 0.4 0.015 15.2 0.4 6.3 4 2 2 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.12 PIK35240.1 - 0.02 15.2 3.1 0.02 15.2 3.1 6.1 4 3 1 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_13 PF18508.1 PIK35240.1 - 0.055 13.1 0.8 0.055 13.1 0.8 4.8 5 0 0 5 5 5 0 Zinc finger domain zf-BED PF02892.15 PIK35240.1 - 0.14 12.2 0.2 0.14 12.2 0.2 7.3 6 3 1 7 7 7 0 BED zinc finger ROS_MUCR PF05443.11 PIK35240.1 - 3.3 7.8 6.2 51 3.9 5.5 2.9 1 1 0 1 1 1 0 ROS/MUCR transcriptional regulator protein zf-H2C2_2 PF13465.6 PIK35241.1 - 8.6e-20 70.2 64.3 2.4e-06 27.7 0.8 9.9 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK35241.1 - 1.2e-18 66.2 70.5 0.0041 17.8 1.4 9.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35241.1 - 5.5e-08 32.8 78.7 0.003 17.9 2.7 9.4 9 2 0 9 9 9 6 Zinc finger, C2H2 type zf-BED PF02892.15 PIK35241.1 - 0.0019 18.2 57.1 1.3 9.1 0.7 8.6 3 1 4 7 7 6 4 BED zinc finger zf-C2H2_jaz PF12171.8 PIK35241.1 - 0.005 17.1 45.2 1.7 9.0 0.4 9.2 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 PIK35241.1 - 0.06 12.9 0.7 0.06 12.9 0.7 7.2 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger PRP21_like_P PF12230.8 PIK35241.1 - 0.086 12.7 6.6 7.1 6.4 0.7 3.4 2 1 1 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein zf-met PF12874.7 PIK35241.1 - 0.11 12.9 0.1 0.11 12.9 0.1 8.0 8 1 0 8 8 7 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK35241.1 - 0.12 12.3 32.6 0.55 10.2 0.4 7.7 6 3 2 8 8 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Ribosomal_S27e PF01667.17 PIK35241.1 - 0.24 11.1 0.2 0.24 11.1 0.2 4.4 6 0 0 6 6 5 0 Ribosomal protein S27 zinc_ribbon_15 PF17032.5 PIK35241.1 - 0.56 11.0 33.3 1.7 9.4 3.5 4.9 2 2 2 4 4 4 0 zinc-ribbon family zf_C2H2_13 PF18508.1 PIK35241.1 - 0.58 9.8 14.3 2 8.0 0.1 4.6 4 1 0 4 4 4 0 Zinc finger domain Ribosomal_L28 PF00830.19 PIK35241.1 - 0.83 9.9 11.2 4.8 7.5 0.5 4.5 3 1 1 4 4 4 0 Ribosomal L28 family GAGA PF09237.11 PIK35241.1 - 1.3 8.8 7.8 2.8 7.8 0.0 4.0 3 1 1 4 4 4 0 GAGA factor Desulfoferrod_N PF06397.12 PIK35241.1 - 1.8 8.3 16.8 1.6 8.4 0.1 5.3 5 0 0 5 5 5 0 Desulfoferrodoxin, N-terminal domain zf-C2HC_2 PF13913.6 PIK35241.1 - 4.3 7.3 28.5 0.44 10.5 0.3 6.2 6 0 0 6 6 5 0 zinc-finger of a C2HC-type zf-RING_7 PF02591.15 PIK35241.1 - 5 7.4 16.7 4.2 7.6 0.2 5.0 5 0 0 5 5 4 0 C4-type zinc ribbon domain zf-C2H2_2 PF12756.7 PIK35243.1 - 0.042 14.2 1.2 6.1 7.3 0.1 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Hamartin PF04388.12 PIK35243.1 - 0.049 12.3 23.7 0.052 12.2 23.7 1.1 1 0 0 1 1 1 0 Hamartin protein ADD_ATRX PF17981.1 PIK35243.1 - 0.19 11.6 1.4 2.1 8.3 0.2 2.6 2 0 0 2 2 2 0 Cysteine Rich ADD domain zf-C2H2_4 PF13894.6 PIK35243.1 - 0.63 11.0 7.8 0.6 11.1 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35243.1 - 1.6 9.3 6.7 0.26 11.8 0.8 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK35243.1 - 7.3 7.0 6.9 14 6.1 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding HlyIII PF03006.20 PIK35245.1 - 1.4e-07 31.4 0.5 2.1e-07 30.9 0.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related NACHT PF05729.12 PIK35247.1 - 4.4e-14 52.7 0.0 7.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK35247.1 - 0.016 14.8 0.1 0.047 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain zf-C3HC4_2 PF13923.6 PIK35248.1 - 4.6e-13 48.8 6.9 9.3e-13 47.8 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK35248.1 - 2.8e-11 43.1 5.9 2.8e-11 43.1 5.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35248.1 - 2e-10 40.5 7.4 4.6e-10 39.3 7.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK35248.1 - 9.5e-10 38.7 6.3 2.2e-09 37.5 6.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK35248.1 - 1.5e-07 31.5 5.5 3.7e-07 30.2 5.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK35248.1 - 1.8e-07 30.9 5.3 4e-07 29.8 5.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK35248.1 - 3.3e-06 27.3 7.2 5.7e-06 26.5 5.6 2.2 2 1 0 2 2 1 1 RING-H2 zinc finger domain U-box PF04564.15 PIK35248.1 - 2.8e-05 24.2 0.1 7.5e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 U-box domain Prok-RING_4 PF14447.6 PIK35248.1 - 2.9e-05 23.8 4.5 6.9e-05 22.6 4.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK35248.1 - 5.4e-05 23.1 5.2 0.00013 21.8 5.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 PIK35248.1 - 0.0075 16.4 4.1 0.0075 16.4 4.1 1.7 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 PIK35248.1 - 0.017 15.0 1.8 0.038 13.9 1.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 PIK35248.1 - 0.017 14.9 2.4 0.04 13.7 2.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 PIK35248.1 - 0.038 14.0 1.7 0.038 14.0 1.7 1.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 PIK35248.1 - 0.091 12.6 4.9 0.39 10.5 5.0 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 PIK35248.1 - 0.22 11.3 5.1 0.58 9.9 5.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger GTP_EFTU PF00009.27 PIK35249.1 - 1.7e-44 151.7 0.0 3.1e-44 150.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 PIK35249.1 - 6.4e-31 107.0 2.3 1.4e-30 105.9 0.0 2.7 4 0 0 4 4 4 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 PIK35249.1 - 0.00019 21.8 0.0 0.0006 20.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 PIK35249.1 - 0.00039 20.5 0.1 0.0028 17.7 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase LPD34 PF18852.1 PIK35249.1 - 0.024 14.2 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 RsgA_GTPase PF03193.16 PIK35249.1 - 0.047 13.6 0.0 4.1 7.3 0.0 2.4 1 1 1 2 2 2 0 RsgA GTPase G-alpha PF00503.20 PIK35249.1 - 0.051 12.7 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit CAC1F_C PF16885.5 PIK35249.1 - 0.19 11.4 3.6 0.25 11.0 3.6 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term RNase_H2_suC PF08615.11 PIK35249.1 - 0.4 10.9 2.1 0.56 10.4 1.1 1.7 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Methyltransf_16 PF10294.9 PIK35250.1 - 7.8e-14 51.8 2.4 2.4e-12 46.9 2.4 2.2 1 1 0 1 1 1 1 Lysine methyltransferase Gtr1_RagA PF04670.12 PIK35250.1 - 0.00039 19.9 0.8 0.00063 19.2 0.8 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Methyltransf_25 PF13649.6 PIK35250.1 - 0.0028 18.3 0.1 0.014 16.1 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK35250.1 - 0.064 13.1 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Telomere_reg-2 PF10193.9 PIK35251.1 - 1.9e-36 124.8 0.1 7.7e-36 122.9 0.1 2.2 1 0 0 1 1 1 1 Telomere length regulation protein Kin17_mid PF10357.9 PIK35253.1 - 7.9e-50 168.0 0.8 7.9e-50 168.0 0.8 2.3 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 PIK35253.1 - 7.8e-20 70.7 3.5 1.4e-19 69.9 3.5 1.5 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain zf-met PF12874.7 PIK35253.1 - 0.00056 20.2 6.2 0.0013 19.0 6.2 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK35253.1 - 0.0016 18.6 5.6 0.0016 18.6 5.6 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK35253.1 - 0.015 15.6 0.3 0.015 15.6 0.3 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Ndc1_Nup PF09531.10 PIK35253.1 - 0.23 10.1 3.1 0.31 9.7 3.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AKAP95 PF04988.12 PIK35253.1 - 5.5 7.2 14.3 0.075 13.3 1.3 2.8 2 1 1 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Ribosomal_L6e PF01159.19 PIK35253.1 - 8 7.0 9.8 0.72 10.4 3.9 2.2 2 0 0 2 2 2 0 Ribosomal protein L6e zf-CCHC PF00098.23 PIK35254.1 - 1.8e-40 135.2 47.9 2.5e-08 33.6 2.4 6.2 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35254.1 - 1e-08 34.7 26.1 0.058 13.1 0.6 5.2 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_5 PF14787.6 PIK35254.1 - 3.4e-08 33.1 35.2 0.021 14.5 1.1 6.0 3 2 3 6 6 6 4 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK35254.1 - 4.4e-06 26.5 35.4 0.045 13.7 1.2 5.4 3 2 3 6 6 6 5 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35254.1 - 0.0013 18.5 36.1 0.021 14.7 1.3 5.5 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_6 PF15288.6 PIK35254.1 - 0.093 12.6 1.2 0.093 12.6 1.2 5.2 4 1 1 5 5 5 0 Zinc knuckle DUF753 PF05444.12 PIK35254.1 - 2.5 8.1 25.8 4 7.4 9.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF753) Clusterin PF01093.17 PIK35254.1 - 2.7 6.9 6.3 3.9 6.4 6.3 1.2 1 0 0 1 1 1 0 Clusterin Ank_4 PF13637.6 PIK35255.1 - 3.4e-38 129.5 6.1 3.9e-12 46.4 0.1 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK35255.1 - 2.3e-37 127.4 1.5 9.7e-15 54.9 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK35255.1 - 5.4e-32 109.4 12.9 9.4e-09 35.4 0.2 5.8 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK35255.1 - 2.8e-31 104.1 0.2 1e-06 28.6 0.1 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 PIK35255.1 - 1e-30 104.8 2.2 2.8e-07 30.7 0.1 5.9 6 0 0 6 6 6 5 Ankyrin repeat Macoilin PF09726.9 PIK35256.1 - 2.3e-05 23.2 0.8 2.3e-05 23.2 0.8 2.2 2 0 0 2 2 2 1 Macoilin family DUF1421 PF07223.11 PIK35256.1 - 0.0002 21.1 0.0 0.0004 20.2 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain (DUF1421) Spectrin PF00435.21 PIK35256.1 - 0.026 15.0 19.2 0.66 10.5 1.7 2.7 2 0 0 2 2 2 0 Spectrin repeat AAA_15 PF13175.6 PIK35256.1 - 0.3 10.8 14.6 2.6 7.6 7.4 2.1 2 0 0 2 2 2 0 AAA ATPase domain Laminin_II PF06009.12 PIK35256.1 - 1.4 8.9 21.0 0.027 14.5 3.1 2.3 2 0 0 2 2 2 0 Laminin Domain II DUF4763 PF15960.5 PIK35256.1 - 2.2 7.5 27.3 0.48 9.7 13.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) FAM221 PF14753.6 PIK35259.1 - 7.7e-25 87.6 10.8 5.6e-14 52.2 4.3 2.2 2 0 0 2 2 2 2 Protein FAM221A/B EamA PF00892.20 PIK35260.1 - 1.1e-22 80.7 33.2 3.9e-14 53.0 9.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK35260.1 - 3.4e-07 29.9 12.2 5.9e-07 29.1 12.2 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family Spt20 PF12090.8 PIK35261.1 - 1.2e-28 100.4 51.7 1.1e-14 54.6 0.1 4.6 3 1 1 4 4 4 3 Spt20 family TPR_MLP1_2 PF07926.12 PIK35262.1 - 0.002 18.2 2.8 0.002 18.2 2.8 1.6 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein PapC_N PF13954.6 PIK35262.1 - 0.022 14.7 0.4 4.1 7.4 0.0 2.2 1 1 1 2 2 2 0 PapC N-terminal domain Laminin_II PF06009.12 PIK35262.1 - 0.078 13.0 2.1 0.38 10.8 1.5 2.0 2 0 0 2 2 2 0 Laminin Domain II Imm43 PF15570.6 PIK35262.1 - 0.98 9.4 4.6 4.2 7.4 0.3 2.2 1 1 1 2 2 2 0 Immunity protein 43 Exonuc_VII_L PF02601.15 PIK35262.1 - 7.5 6.0 6.3 11 5.5 6.3 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit Aminotran_5 PF00266.19 PIK35263.1 - 4.8e-33 114.6 0.0 8.8e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK35263.1 - 1.7e-05 24.2 0.0 3.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II 7tm_1 PF00001.21 PIK35264.1 - 2.3e-25 89.4 4.6 2.9e-25 89.1 4.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35264.1 - 4.3e-09 36.4 12.8 5.9e-09 35.9 12.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK35264.1 - 1.2e-07 31.4 9.7 1.2e-07 31.4 9.7 1.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK35264.1 - 1.3e-05 24.7 13.2 2e-05 24.1 13.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Cpn60_TCP1 PF00118.24 PIK35265.1 - 3.9e-40 137.9 0.5 4.4e-40 137.7 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ntox30 PF15532.6 PIK35266.1 - 0.039 14.3 0.9 0.087 13.2 0.9 1.5 1 0 0 1 1 1 0 Bacterial toxin 30 DUF1981 PF09324.10 PIK35267.1 - 0.0035 17.2 3.2 1.4 8.8 0.1 4.3 3 1 1 4 4 4 2 Domain of unknown function (DUF1981) DCB PF16213.5 PIK35268.1 - 1.3e-05 25.0 7.9 1.5e-05 24.7 5.2 2.1 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 PIK35268.1 - 0.028 14.3 1.1 0.096 12.6 0.1 2.4 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Astacin PF01400.24 PIK35269.1 - 1.1e-52 178.4 0.3 2.4e-52 177.3 0.3 1.5 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Kringle PF00051.18 PIK35269.1 - 6.9e-22 77.6 9.5 6.9e-22 77.6 9.5 2.3 3 0 0 3 3 3 1 Kringle domain Reprolysin_3 PF13582.6 PIK35269.1 - 0.0035 17.9 0.1 0.0077 16.7 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK35269.1 - 0.0049 16.7 0.0 0.014 15.3 0.0 1.8 2 0 0 2 2 2 1 Matrixin Peptidase_M66 PF10462.9 PIK35269.1 - 0.023 13.7 0.0 0.05 12.5 0.0 1.5 1 1 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.6 PIK35269.1 - 0.043 13.5 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Helicase_C PF00271.31 PIK35270.1 - 6.3e-24 84.5 0.0 1.8e-23 83.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK35270.1 - 3.4e-14 52.8 0.0 6.8e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Presenilin PF01080.17 PIK35270.1 - 7.8 5.1 12.3 13 4.4 12.3 1.3 1 0 0 1 1 1 0 Presenilin DEAD PF00270.29 PIK35271.1 - 1.8e-21 76.7 0.0 2.8e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK35271.1 - 0.065 13.2 0.6 0.38 10.7 0.0 2.3 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit Arm PF00514.23 PIK35273.1 - 7.4e-33 111.6 8.5 3e-09 36.6 0.1 6.1 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK35273.1 - 1.2e-06 28.8 1.5 0.022 15.2 0.0 2.6 2 0 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 PIK35273.1 - 0.00039 20.9 1.2 0.36 11.4 0.0 4.2 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 PIK35273.1 - 0.0008 19.5 2.6 0.55 10.6 0.0 3.9 4 0 0 4 4 4 2 HEAT repeat REJ PF02010.15 PIK35274.1 - 4.5e-65 220.2 7.4 7.5e-55 186.5 0.1 3.1 3 1 1 4 4 4 2 REJ domain PKD PF00801.20 PIK35274.1 - 6.8e-08 32.2 3.6 0.013 15.4 0.2 4.4 3 0 0 3 3 3 2 PKD domain GPS PF01825.21 PIK35274.1 - 0.0038 17.7 4.4 0.017 15.7 4.4 2.2 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Y_Y_Y PF07495.13 PIK35274.1 - 0.056 13.4 2.8 4.2 7.4 0.0 3.6 5 0 0 5 5 5 0 Y_Y_Y domain Lep_receptor_Ig PF06328.11 PIK35274.1 - 7.6 6.6 6.4 28 4.7 0.1 3.6 3 0 0 3 3 3 0 Ig-like C2-type domain PKD_channel PF08016.12 PIK35275.1 - 8.4e-89 298.2 10.0 8.4e-89 298.2 10.0 1.7 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 PIK35275.1 - 2.4e-06 26.9 12.2 2.4e-06 26.9 12.2 2.1 2 0 0 2 2 2 1 Ion transport protein PGG PF13962.6 PIK35275.1 - 9.9 6.0 9.4 0.6 10.0 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function DnaJ_C PF01556.18 PIK35276.1 - 1.3e-39 135.7 0.5 2e-39 135.0 0.5 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 PIK35276.1 - 7.7e-25 86.8 0.7 1.3e-24 86.1 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 PIK35276.1 - 9.6e-15 54.7 23.3 1.6e-14 54.0 23.3 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 PIK35276.1 - 0.067 13.2 10.1 1.2 9.2 0.3 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_UBOX PF13445.6 PIK35277.1 - 7.4e-08 32.3 6.8 7.4e-08 32.3 6.8 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK35277.1 - 1.5e-06 28.0 8.0 1.5e-06 28.0 8.0 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK35277.1 - 0.00011 22.3 4.3 0.00011 22.3 4.3 3.3 3 1 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.6 PIK35277.1 - 0.00021 21.6 8.6 0.00021 21.6 8.6 2.5 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK35277.1 - 0.00025 20.8 6.9 0.00025 20.8 6.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35277.1 - 0.00049 19.9 9.2 0.00049 19.9 9.2 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK35277.1 - 0.00078 19.6 8.3 0.00078 19.6 8.3 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK35277.1 - 0.0031 17.4 8.2 0.0031 17.4 8.2 2.8 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK35277.1 - 0.012 15.5 9.0 0.012 15.5 9.0 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 FYVE_2 PF02318.16 PIK35277.1 - 0.55 10.5 9.5 5.2 7.3 2.2 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger zf-RING_6 PF14835.6 PIK35277.1 - 6.2 6.8 9.1 0.18 11.7 1.6 2.4 2 2 0 2 2 2 0 zf-RING of BARD1-type protein PP2C_C PF07830.13 PIK35278.1 - 0.1 13.0 3.6 0.64 10.5 0.7 2.4 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain CobN-Mg_chel PF02514.16 PIK35278.1 - 0.24 9.1 3.6 0.3 8.8 3.6 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase DUF2203 PF09969.9 PIK35278.1 - 5.4 7.8 5.8 1.2 9.8 0.6 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SUIM_assoc PF16619.5 PIK35278.1 - 8.9 6.5 8.5 5.9 7.0 0.1 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 SAM_1 PF00536.30 PIK35279.1 - 0.0074 16.7 0.1 0.012 16.0 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-CCHC PF00098.23 PIK35280.1 - 9.2e-06 25.5 2.6 1.8e-05 24.6 2.6 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35280.1 - 0.11 12.2 0.6 0.2 11.4 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Y_phosphatase PF00102.27 PIK35281.1 - 1.2e-54 185.3 0.0 1.8e-54 184.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK35281.1 - 0.013 15.3 0.3 0.026 14.3 0.0 1.7 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK35281.1 - 0.02 14.9 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family RR_TM4-6 PF06459.12 PIK35281.1 - 2.4 7.9 7.4 3.5 7.4 7.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 7tm_1 PF00001.21 PIK35282.1 - 6.6e-15 55.1 8.5 8.7e-15 54.7 8.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK35282.1 - 0.0021 17.5 8.7 0.0026 17.2 8.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK35282.1 - 0.0062 15.9 8.3 0.0073 15.7 8.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv HIG_1_N PF04588.13 PIK35282.1 - 0.25 11.6 0.2 0.25 11.6 0.2 2.2 2 1 0 2 2 2 0 Hypoxia induced protein conserved region HemY_N PF07219.13 PIK35282.1 - 6.5 7.0 5.9 0.79 9.9 0.2 2.1 1 1 1 2 2 2 0 HemY protein N-terminus 7tm_1 PF00001.21 PIK35283.1 - 3e-25 89.0 3.1 3.7e-25 88.8 3.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35283.1 - 6.9e-07 29.2 10.5 9.2e-07 28.8 10.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK35283.1 - 3.4e-06 26.6 6.5 4.6e-06 26.2 6.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK35283.1 - 9.1e-06 25.6 3.1 1.1e-05 25.3 3.1 1.0 1 0 0 1 1 1 1 Olfactory receptor VWC PF00093.18 PIK35284.1 - 3.7e-09 36.7 18.3 3.1e-05 24.2 2.9 2.9 3 0 0 3 3 3 2 von Willebrand factor type C domain TILa PF12714.7 PIK35284.1 - 0.00021 21.2 14.9 0.062 13.3 3.3 2.7 2 0 0 2 2 2 2 TILa domain Ninjurin PF04923.12 PIK35284.1 - 0.026 14.4 0.2 0.046 13.7 0.2 1.3 1 0 0 1 1 1 0 Ninjurin VWC PF00093.18 PIK35285.1 - 2.4e-08 34.2 29.3 3.8e-05 23.9 3.3 3.0 3 0 0 3 3 3 2 von Willebrand factor type C domain TILa PF12714.7 PIK35285.1 - 0.025 14.5 3.8 0.025 14.5 3.8 3.0 2 1 1 3 3 3 0 TILa domain Ninjurin PF04923.12 PIK35285.1 - 0.028 14.3 0.1 0.055 13.4 0.1 1.4 1 0 0 1 1 1 0 Ninjurin Cadherin_C_2 PF16492.5 PIK35285.1 - 0.034 14.9 1.6 2.8 8.7 0.7 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF4798 PF16055.5 PIK35286.1 - 0.3 11.3 6.7 6.9 7.0 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) Tweety PF04906.13 PIK35287.1 - 7.8e-28 97.3 0.7 1.1e-27 96.8 0.7 1.1 1 0 0 1 1 1 1 Tweety Tweety PF04906.13 PIK35288.1 - 8.2e-09 34.6 0.1 9.5e-09 34.4 0.1 1.0 1 0 0 1 1 1 1 Tweety NPV_P10 PF05531.12 PIK35288.1 - 0.045 14.2 1.9 1 9.9 0.2 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein RWD PF05773.22 PIK35289.1 - 1.4e-14 54.4 0.2 1.8e-14 54.0 0.2 1.1 1 0 0 1 1 1 1 RWD domain Sulfotransfer_2 PF03567.14 PIK35290.1 - 1.8e-16 60.8 1.9 7.6e-16 58.8 1.9 1.9 1 1 0 1 1 1 1 Sulfotransferase family LRR_8 PF13855.6 PIK35291.1 - 1.9e-26 91.6 24.9 3.8e-10 39.4 1.6 5.4 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK35291.1 - 1e-19 70.3 25.0 6.7e-07 29.5 2.1 6.1 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK35291.1 - 3e-07 30.1 8.8 0.00062 19.3 1.6 2.5 2 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK35291.1 - 0.00022 21.3 26.0 1.3 9.9 0.3 7.4 8 1 0 8 8 8 4 Leucine Rich Repeat LRR_6 PF13516.6 PIK35291.1 - 6 7.2 23.5 0.93 9.7 0.2 5.6 6 0 0 6 6 6 0 Leucine Rich repeat LRR_4 PF12799.7 PIK35292.1 - 8.7e-15 54.6 25.8 4.4e-05 23.7 0.5 5.5 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK35292.1 - 4.9e-13 48.6 26.0 4.7e-05 23.1 0.3 5.6 3 1 2 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 PIK35292.1 - 7.7e-11 41.8 22.6 0.00012 21.7 4.8 3.9 3 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 PIK35292.1 - 0.016 15.2 5.3 4.2 7.7 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich repeat Microtub_bind PF13931.6 PIK35292.1 - 0.56 10.6 3.7 4.3 7.7 0.4 2.4 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding TB2_DP1_HVA22 PF03134.19 PIK35293.1 - 8e-21 73.8 1.0 1.2e-20 73.2 1.0 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RT_RNaseH PF17917.1 PIK35294.1 - 7.4e-32 109.8 2.0 2.1e-31 108.3 0.1 2.6 3 0 0 3 3 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK35294.1 - 1.2e-29 102.2 0.2 3.7e-29 100.7 0.1 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK35294.1 - 1.4e-22 80.3 0.1 2.9e-22 79.3 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK35294.1 - 1.1e-19 70.8 0.0 3.7e-19 69.1 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK35294.1 - 2.4e-16 59.6 2.3 2.7e-16 59.4 0.4 2.2 2 0 0 2 2 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK35294.1 - 0.00044 20.2 11.4 0.0073 16.3 2.4 2.8 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 PIK35294.1 - 0.05 14.2 0.0 0.12 13.0 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Baculo_VP39 PF04501.12 PIK35294.1 - 0.05 13.1 1.3 1.6 8.2 0.8 2.3 2 0 0 2 2 2 0 Baculovirus major capsid protein VP39 rve_3 PF13683.6 PIK35294.1 - 0.051 13.4 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain Retrotrans_gag PF03732.17 PIK35294.1 - 0.052 13.8 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC_3 PF13917.6 PIK35294.1 - 0.18 11.8 5.6 0.052 13.5 0.8 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35294.1 - 0.35 10.7 1.5 1.1 9.2 1.5 1.9 1 0 0 1 1 1 0 Zinc knuckle Swi3 PF07962.12 PIK35296.1 - 2.2e-27 94.8 0.9 4.8e-27 93.8 0.9 1.6 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 LTXXQ PF07813.12 PIK35296.1 - 0.26 12.0 0.3 0.26 12.0 0.3 2.9 3 0 0 3 3 3 0 LTXXQ motif family protein GLTSCR1 PF15249.6 PIK35296.1 - 0.76 10.3 6.9 9.5 6.7 1.6 2.6 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein GREB1 PF15782.5 PIK35296.1 - 4.3 4.3 7.7 5.3 4.0 7.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RNB PF00773.19 PIK35297.1 - 2.9e-21 76.2 0.8 4e-21 75.7 0.2 1.6 2 0 0 2 2 2 1 RNB domain Rrp44_S1 PF17215.3 PIK35297.1 - 2e-07 30.9 0.0 5.9e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 S1 domain Cupin_8 PF13621.6 PIK35298.1 - 4.7e-28 98.6 0.1 5.3e-28 98.4 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK35298.1 - 3.6e-11 43.1 0.0 6.5e-11 42.3 0.0 1.4 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 PIK35298.1 - 0.00021 21.7 0.0 0.0011 19.4 0.0 2.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 PIK35298.1 - 0.00055 19.6 0.1 0.0034 17.1 0.0 2.0 2 0 0 2 2 2 1 Cupin domain Cupin_8 PF13621.6 PIK35299.1 - 2.5e-07 30.7 0.0 4.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Zn_ribbon_2 PF12674.7 PIK35299.1 - 0.014 16.0 0.1 0.044 14.4 0.1 1.8 2 0 0 2 2 2 0 Putative zinc ribbon domain NOC3p PF07540.11 PIK35299.1 - 0.14 12.6 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Nucleolar complex-associated protein ParBc PF02195.18 PIK35300.1 - 5.6e-08 33.0 0.0 7.3e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain NT-C2 PF10358.9 PIK35301.1 - 4.5e-21 75.1 0.0 5.3e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Geminin PF07412.12 PIK35302.1 - 0.019 14.7 1.0 0.027 14.2 1.0 1.2 1 0 0 1 1 1 0 Geminin PBP_sp32 PF07222.12 PIK35302.1 - 0.033 13.6 2.9 0.045 13.2 2.9 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4545 PF15078.6 PIK35302.1 - 0.08 11.9 5.2 0.11 11.5 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4545) CCDC106 PF15794.5 PIK35302.1 - 0.19 11.4 9.9 0.3 10.8 9.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 VIR_N PF15912.5 PIK35302.1 - 0.92 9.0 4.9 1.4 8.5 4.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal SOBP PF15279.6 PIK35302.1 - 1.8 9.1 7.7 2.1 8.8 7.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein GIY-YIG PF01541.24 PIK35303.1 - 0.00013 22.2 0.7 0.0012 19.1 0.1 2.5 2 0 0 2 2 2 1 GIY-YIG catalytic domain DUF3449 PF11931.8 PIK35303.1 - 0.055 13.3 0.5 0.094 12.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) C2 PF00168.30 PIK35304.1 - 5.8e-08 33.0 0.0 1.2e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain Phage_antiter_Q PF06323.11 PIK35304.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Phage antitermination protein Q PH PF00169.29 PIK35304.1 - 0.023 15.2 0.1 0.045 14.3 0.1 1.6 1 0 0 1 1 1 0 PH domain RhoGAP PF00620.27 PIK35305.1 - 4.9e-14 52.4 0.0 8.2e-14 51.7 0.0 1.4 2 0 0 2 2 2 1 RhoGAP domain MRP-63 PF14978.6 PIK35306.1 - 6.3 7.5 17.4 3.4 8.4 2.2 3.8 1 1 3 4 4 4 0 Mitochondrial ribosome protein 63 Ribosomal_L35p PF01632.19 PIK35306.1 - 9.9 6.8 11.7 3.3 8.3 0.6 3.5 2 2 1 3 3 3 0 Ribosomal protein L35 7tm_1 PF00001.21 PIK35307.1 - 2e-35 122.4 4.4 2.5e-35 122.1 4.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35307.1 - 0.00041 20.1 7.7 0.00084 19.0 7.7 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx RVT_1 PF00078.27 PIK35308.1 - 0.0087 15.6 0.0 0.0097 15.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK35309.1 - 8.8e-11 42.0 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK35309.1 - 2.4e-07 30.9 1.2 4.9e-07 29.9 0.5 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK35309.1 - 1.9e-06 28.4 0.9 4.7e-06 27.1 0.9 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK35309.1 - 4.5e-06 26.6 0.7 1.1e-05 25.3 0.7 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK35309.1 - 9e-05 22.7 3.2 0.00026 21.3 3.2 1.8 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK35309.1 - 0.00023 21.3 0.2 0.00051 20.2 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain IstB_IS21 PF01695.17 PIK35309.1 - 0.057 13.2 0.0 0.28 10.9 0.0 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein Myb_DNA-bind_5 PF13873.6 PIK35310.1 - 9.8e-06 25.6 1.6 1.5e-05 25.0 1.6 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DDE_Tnp_4 PF13359.6 PIK35311.1 - 1.6e-32 112.4 0.0 2.4e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK35311.1 - 7.1e-07 29.0 0.0 1.9e-05 24.3 0.0 2.1 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 PIK35311.1 - 9.9e-06 25.3 0.0 2.7e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Transposase DDE domain LBR_tudor PF09465.10 PIK35311.1 - 0.038 13.8 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain NHL PF01436.21 PIK35312.1 - 0.0021 18.0 0.0 0.97 9.6 0.0 2.8 2 0 0 2 2 2 2 NHL repeat Pkinase_Tyr PF07714.17 PIK35313.1 - 1.8e-24 86.4 0.0 3.1e-24 85.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35313.1 - 2.1e-16 60.1 0.0 4.8e-16 58.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK35313.1 - 0.0032 17.5 0.0 0.02 15.0 0.0 2.2 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain Aa_trans PF01490.18 PIK35314.1 - 1.2e-58 198.7 27.6 1.4e-58 198.5 27.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 PIK35314.1 - 5.3e-09 35.6 24.1 1.1e-08 34.5 24.1 1.6 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family DUF4131 PF13567.6 PIK35314.1 - 1.2 8.7 13.6 0.17 11.5 0.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) Spore_permease PF03845.13 PIK35314.1 - 2.7 6.7 21.8 0.068 12.0 13.1 2.7 2 1 0 2 2 2 0 Spore germination protein 7tm_1 PF00001.21 PIK35315.1 - 9.1e-08 31.7 19.9 1.3e-06 28.0 19.9 2.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 PIK35315.1 - 1.5 8.3 23.5 0.015 14.9 14.0 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_2 PF00002.24 PIK35316.1 - 6.3e-36 123.9 17.4 9.3e-36 123.3 17.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK35316.1 - 3.5e-09 37.0 2.4 5.9e-09 36.3 0.6 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Ocular_alb PF02101.15 PIK35316.1 - 0.0006 18.8 9.7 0.16 10.8 4.5 2.2 2 0 0 2 2 2 2 Ocular albinism type 1 protein Ctr PF04145.15 PIK35316.1 - 0.053 14.1 0.3 0.053 14.1 0.3 2.3 3 0 0 3 3 3 0 Ctr copper transporter family Sulfotransfer_1 PF00685.27 PIK35319.1 - 8.7e-16 58.2 0.2 9.6e-16 58.0 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK35320.1 - 1.3e-13 51.0 0.0 3.2e-13 49.8 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK35321.1 - 8.2e-60 202.5 0.0 1.1e-59 202.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK35321.1 - 4.9e-06 27.1 0.0 9.3e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK35322.1 - 3.4e-62 210.3 0.1 9.3e-62 208.9 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK35322.1 - 1.5e-08 35.3 0.0 4.4e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family SpoVIF PF14069.6 PIK35322.1 - 0.096 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Stage VI sporulation protein F AhpC-TSA PF00578.21 PIK35325.1 - 2.6e-27 95.2 0.0 3.1e-27 95.0 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK35325.1 - 9.2e-08 31.9 0.0 1.1e-07 31.7 0.0 1.0 1 0 0 1 1 1 1 Redoxin fn3 PF00041.21 PIK35326.1 - 1.3e-12 47.8 2.1 6.4e-06 26.4 0.1 3.5 3 0 0 3 3 3 2 Fibronectin type III domain TMEM154 PF15102.6 PIK35326.1 - 0.0048 16.8 0.1 0.0088 16.0 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family Tissue_fac PF01108.17 PIK35326.1 - 0.018 14.9 0.1 0.46 10.4 0.0 2.6 3 0 0 3 3 3 0 Tissue factor PRIMA1 PF16101.5 PIK35326.1 - 0.089 12.8 0.9 0.16 12.0 0.3 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Myco_arth_vir_N PF09610.10 PIK35326.1 - 0.84 9.8 6.2 0.081 13.0 1.0 1.9 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Ldh_2 PF02615.14 PIK35327.1 - 1e-88 297.8 0.0 5.1e-77 259.3 0.0 2.0 2 0 0 2 2 2 2 Malate/L-lactate dehydrogenase TRIC PF05197.13 PIK35328.1 - 8.4e-40 136.4 0.8 9.7e-40 136.2 0.8 1.0 1 0 0 1 1 1 1 TRIC channel I-set PF07679.16 PIK35329.1 - 4.7e-29 100.3 0.0 3.2e-15 56.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35329.1 - 5.1e-23 81.5 0.0 2.4e-11 44.1 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK35329.1 - 7.5e-16 58.2 0.0 8.9e-09 35.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK35329.1 - 3e-14 52.9 0.0 6.9e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK35329.1 - 9.1e-08 32.2 0.8 6.9e-05 23.0 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK35329.1 - 2e-05 24.1 0.0 0.0082 15.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK35329.1 - 0.00059 19.8 0.0 0.27 11.3 0.0 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Trypan_PARP PF05887.11 PIK35329.1 - 0.21 11.6 31.6 0.78 9.7 31.6 2.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PDZ PF00595.24 PIK35330.1 - 6.2e-31 106.6 1.8 5.6e-10 39.4 0.1 3.6 3 1 1 4 4 4 3 PDZ domain PDZ_6 PF17820.1 PIK35330.1 - 5.1e-16 58.3 0.5 7.3e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK35330.1 - 6.3e-13 48.9 0.1 0.0003 21.0 0.0 3.4 3 0 0 3 3 3 3 PDZ domain Med25_VWA PF11265.8 PIK35331.1 - 3.4e-23 82.6 0.0 3.9e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Med25_VWA PF11265.8 PIK35332.1 - 2.7e-13 50.2 0.0 2.7e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 Mediator complex subunit 25 von Willebrand factor type A Med25 PF11232.8 PIK35332.1 - 8.5e-13 48.5 0.9 3.5e-10 40.1 0.0 6.6 4 2 1 6 6 6 2 Mediator complex subunit 25 PTOV activation and synapsin 2 p450 PF00067.22 PIK35333.1 - 2.1e-86 290.5 0.0 2.5e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dak2 PF02734.17 PIK35335.1 - 4.8e-29 101.5 0.6 6.7e-29 101.0 0.6 1.2 1 0 0 1 1 1 1 DAK2 domain Dak1 PF02733.17 PIK35336.1 - 8.9e-33 113.5 0.3 1.1e-32 113.2 0.3 1.0 1 0 0 1 1 1 1 Dak1 domain DUF3510 PF12022.8 PIK35337.1 - 1.7e-14 54.3 2.0 3.6e-14 53.2 0.0 2.6 3 1 0 3 3 3 1 Domain of unknown function (DUF3510) COG2 PF06148.11 PIK35337.1 - 0.062 13.4 1.5 0.12 12.5 0.7 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 COG2 PF06148.11 PIK35338.1 - 6.6e-16 58.6 0.2 7.5e-16 58.4 0.2 1.0 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Nse4-Nse3_bdg PF15412.6 PIK35338.1 - 0.047 13.8 0.2 0.14 12.3 0.2 1.8 1 1 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE Ribosomal_S10 PF00338.22 PIK35339.1 - 1.4e-20 73.4 0.1 1.9e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Cwf_Cwc_15 PF04889.12 PIK35339.1 - 0.0017 18.2 8.5 0.0026 17.6 8.5 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 PIK35339.1 - 4.4 5.3 16.1 5.7 4.9 16.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi AF-4 PF05110.13 PIK35339.1 - 6 4.8 24.9 8.3 4.4 24.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein LRR_4 PF12799.7 PIK35340.1 - 3.3e-11 43.2 4.9 1e-05 25.8 0.0 2.7 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK35340.1 - 6.7e-08 32.2 0.1 2.4e-07 30.5 0.1 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 PIK35340.1 - 6.8e-07 29.0 3.9 0.0019 17.9 0.1 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 PIK35340.1 - 0.026 15.0 4.2 5.3 8.0 0.0 4.0 4 1 0 4 4 4 0 Leucine Rich Repeat U3snoRNP10 PF12397.8 PIK35340.1 - 0.16 12.4 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 10 zf-CCHC_6 PF15288.6 PIK35341.1 - 0.35 10.7 5.9 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35341.1 - 1.2 8.9 8.4 0.065 13.0 2.2 2.2 3 0 0 3 3 3 0 Zinc knuckle Death PF00531.22 PIK35342.1 - 5.8e-14 52.0 0.1 6.5e-14 51.9 0.1 1.0 1 0 0 1 1 1 1 Death domain UPA PF17217.3 PIK35343.1 - 0.071 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 UPA domain ZU5 PF00791.20 PIK35344.1 - 2e-11 44.1 0.1 3.7e-11 43.2 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain NACHT PF05729.12 PIK35345.1 - 2.6e-08 34.0 0.0 5.4e-08 32.9 0.0 1.5 2 0 0 2 2 2 1 NACHT domain TrmB PF01978.19 PIK35345.1 - 0.0043 16.9 0.0 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB DED PF01335.21 PIK35346.1 - 8.2e-07 29.2 0.5 0.0097 16.2 0.1 2.2 2 0 0 2 2 2 2 Death effector domain BORA_N PF15280.6 PIK35346.1 - 0.048 13.3 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein aurora borealis N-terminus KDZ PF18758.1 PIK35347.1 - 7.2e-08 32.3 0.2 7.9e-08 32.2 0.2 1.1 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase Exo_endo_phos PF03372.23 PIK35348.1 - 0.012 15.2 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF659 PF04937.15 PIK35349.1 - 0.00019 21.4 1.1 0.00043 20.2 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) DUF4413 PF14372.6 PIK35349.1 - 0.028 14.8 0.8 0.64 10.4 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4413) Mt_ATP_synt PF15704.5 PIK35349.1 - 0.08 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit rve PF00665.26 PIK35350.1 - 5.5e-14 52.4 0.0 9.7e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Inos-1-P_synth PF01658.17 PIK35350.1 - 0.099 12.9 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase rve_3 PF13683.6 PIK35350.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 PIK35351.1 - 2.2e-43 148.4 0.1 3e-43 147.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1258 PF06869.12 PIK35352.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) Transposase_21 PF02992.14 PIK35352.1 - 0.012 14.8 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 Transposase family tnp2 Tetraspanin PF00335.20 PIK35353.1 - 1.8e-16 60.6 4.7 2e-16 60.4 4.7 1.0 1 0 0 1 1 1 1 Tetraspanin family Rax2 PF12768.7 PIK35353.1 - 0.018 14.5 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity zf-C3HC4_2 PF13923.6 PIK35354.1 - 3.7e-08 33.1 7.8 1.9e-07 30.8 7.8 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK35354.1 - 7.5e-07 28.9 6.4 7.5e-07 28.9 6.4 2.6 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35354.1 - 2.1e-06 27.7 4.9 2.1e-06 27.7 4.9 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK35354.1 - 4.9e-06 26.4 6.1 4.9e-06 26.4 6.1 2.9 2 1 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK35354.1 - 0.00019 21.2 10.1 0.00019 21.2 10.1 2.4 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-TRAF PF02176.18 PIK35354.1 - 0.0005 20.7 20.1 0.0051 17.5 2.2 3.3 2 1 1 3 3 3 2 TRAF-type zinc finger zf-C3HC4_4 PF15227.6 PIK35354.1 - 0.0016 18.6 9.9 0.0023 18.0 7.7 2.6 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.5 PIK35354.1 - 0.0017 18.8 8.6 0.0017 18.8 8.6 2.0 2 0 0 2 2 2 1 TRAF-like zinc-finger zf-RING_2 PF13639.6 PIK35354.1 - 0.027 14.8 11.3 0.027 14.8 11.3 3.2 2 1 0 2 2 1 0 Ring finger domain TRAF6_Z2 PF18048.1 PIK35354.1 - 5 7.3 11.6 6.3 7.0 0.4 3.4 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 zf-RING_6 PF14835.6 PIK35354.1 - 7.7 6.5 16.1 0.11 12.4 6.2 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Fanconi_A_N PF15865.5 PIK35356.1 - 4.6e-64 217.0 7.4 4.6e-64 217.0 7.4 3.5 3 1 1 4 4 4 1 Fanconi anaemia group A protein N terminus PrmA PF06325.13 PIK35357.1 - 1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK35357.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK35357.1 - 0.00026 21.6 0.1 0.00073 20.2 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 PIK35357.1 - 0.0025 17.6 0.1 0.0042 16.9 0.1 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 PIK35357.1 - 0.0031 17.4 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK35357.1 - 0.0047 16.5 0.0 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 PIK35357.1 - 0.0088 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 PIK35357.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase ATG19_autophagy PF12744.7 PIK35358.1 - 0.0041 16.3 0.0 0.0069 15.6 0.0 1.3 1 0 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding Met_10 PF02475.16 PIK35358.1 - 0.048 13.4 0.0 0.83 9.4 0.0 2.0 2 0 0 2 2 2 0 Met-10+ like-protein RRN3 PF05327.11 PIK35359.1 - 1.4e-62 212.1 0.7 2.3e-35 122.2 0.0 2.1 1 1 1 2 2 2 2 RNA polymerase I specific transcription initiation factor RRN3 Galactosyl_T PF01762.21 PIK35360.1 - 1.7e-38 132.4 0.1 2e-38 132.2 0.1 1.0 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK35360.1 - 6.4e-05 22.5 0.1 7.4e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 Fringe-like DUF4201 PF13870.6 PIK35361.1 - 3.2e-48 163.8 29.7 3.2e-48 163.8 29.7 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4201) SecD-TM1 PF13721.6 PIK35361.1 - 0.14 12.6 1.4 0.3 11.6 0.1 2.2 2 0 0 2 2 2 0 SecD export protein N-terminal TM region Tli4_N PF18443.1 PIK35361.1 - 8.5 6.8 25.3 4.7 7.6 12.1 4.2 1 1 2 3 3 3 0 Tle cognate immunity protein 4 N-terminal domain BIR PF00653.21 PIK35362.1 - 3.1e-26 91.8 4.0 4.6e-26 91.3 4.0 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK35362.1 - 0.00077 19.5 3.2 0.013 15.6 3.2 2.1 1 1 0 1 1 1 1 C3HC zinc finger-like zf-RanBP PF00641.18 PIK35362.1 - 0.016 14.5 0.3 0.052 12.9 0.3 1.8 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Herpes_UL32 PF06070.11 PIK35362.1 - 0.04 11.7 0.1 0.047 11.4 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Sec15 PF04091.12 PIK35362.1 - 0.11 11.8 0.5 0.15 11.5 0.5 1.1 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like PKD_channel PF08016.12 PIK35363.1 - 0.039 12.6 0.9 0.085 11.5 0.9 1.5 1 0 0 1 1 1 0 Polycystin cation channel 7tm_3 PF00003.22 PIK35364.1 - 2.8e-31 109.1 8.8 3.3e-31 108.9 8.8 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Pox_A30L_A26L PF06086.12 PIK35364.1 - 0.005 16.5 0.7 0.0059 16.3 0.7 1.2 1 0 0 1 1 1 1 Orthopoxvirus A26L/A30L protein MSSP PF03940.13 PIK35365.1 - 0.11 12.1 0.5 0.29 10.8 0.5 1.7 1 1 0 1 1 1 0 Male specific sperm protein Complex1_49kDa PF00346.19 PIK35367.1 - 6.2e-118 392.8 0.0 9.1e-118 392.2 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 PIK35367.1 - 0.00045 19.2 0.1 0.0007 18.6 0.1 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase Fibrinogen_C PF00147.18 PIK35368.1 - 8.4e-44 150.0 1.4 1.1e-43 149.6 1.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK35368.1 - 9.9e-07 28.9 9.7 2e-06 27.9 9.7 1.5 1 0 0 1 1 1 1 EGF domain cEGF PF12662.7 PIK35368.1 - 0.055 13.4 4.3 0.055 13.4 4.3 2.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK35368.1 - 0.11 12.9 7.8 0.27 11.6 7.8 1.7 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 PIK35368.1 - 0.25 11.7 5.1 0.55 10.6 5.1 1.6 1 0 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK35369.1 - 1.7e-35 122.8 1.4 2.3e-35 122.4 1.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK35369.1 - 0.00015 22.0 13.0 0.00015 22.0 13.0 1.8 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF PF00008.27 PIK35370.1 - 7.7e-07 29.3 5.6 7.7e-07 29.3 5.6 2.3 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 PIK35370.1 - 0.014 15.7 11.2 0.22 11.9 11.2 2.6 1 1 0 1 1 1 0 EGF-like domain PAG PF15347.6 PIK35370.1 - 0.016 14.2 0.1 0.027 13.5 0.1 1.3 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched EphA2_TM PF14575.6 PIK35370.1 - 0.044 14.6 0.1 0.078 13.9 0.1 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Tmemb_9 PF05434.11 PIK35370.1 - 0.26 11.2 1.5 0.28 11.1 0.3 1.6 2 0 0 2 2 2 0 TMEM9 TMEM154 PF15102.6 PIK35370.1 - 0.82 9.6 2.5 0.46 10.4 0.1 1.8 2 0 0 2 2 2 0 TMEM154 protein family WD40 PF00400.32 PIK35371.1 - 7.1e-14 52.0 14.0 0.0045 17.8 0.2 6.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK35371.1 - 0.00032 20.9 0.1 0.48 10.8 0.1 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK35371.1 - 0.00079 18.5 0.1 0.28 10.1 0.0 2.7 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 PIK35371.1 - 0.0021 16.9 0.0 1.7 7.3 0.0 3.0 3 1 0 3 3 3 2 Nup133 N terminal like Ly49 PF08391.10 PIK35371.1 - 0.71 10.2 4.2 0.6 10.5 0.2 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region EF-hand_7 PF13499.6 PIK35372.1 - 0.0003 21.2 0.6 0.00091 19.6 0.6 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK35372.1 - 0.00097 18.9 0.3 0.004 17.0 0.3 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK35372.1 - 0.011 15.6 2.9 0.28 11.2 0.2 2.8 3 0 0 3 3 3 0 EF-hand domain S_100 PF01023.19 PIK35372.1 - 0.031 14.0 0.6 0.054 13.2 0.6 1.4 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Glyco_transf_36 PF06165.11 PIK35372.1 - 0.046 13.1 0.1 0.076 12.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 36 Hat1_N PF10394.9 PIK35373.1 - 1.9e-42 145.2 0.3 1.9e-42 145.2 0.3 2.2 2 1 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus DUF2624 PF11116.8 PIK35373.1 - 0.25 12.2 2.1 0.42 11.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) EF-hand_1 PF00036.32 PIK35374.1 - 5.4e-11 41.2 1.5 2.2e-07 30.0 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 PIK35374.1 - 7.8e-11 41.0 0.4 3.7e-07 29.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK35374.1 - 1.1e-09 37.4 1.1 3.7e-06 26.4 0.1 3.2 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 PIK35374.1 - 6e-09 35.6 1.2 0.0015 18.3 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 PIK35374.1 - 3.2e-08 33.9 0.4 0.0025 18.2 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair VWA_3_C PF18571.1 PIK35374.1 - 0.21 11.5 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A C-terminal domain Mito_carr PF00153.27 PIK35375.1 - 8e-69 227.6 0.2 4.8e-24 84.1 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_6 PF13405.6 PIK35375.1 - 0.0013 18.4 0.0 0.0086 15.9 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 PIK35375.1 - 0.0036 17.7 0.1 0.029 14.8 0.1 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK35375.1 - 0.012 15.1 0.0 0.07 12.7 0.0 2.2 2 0 0 2 2 2 0 EF hand V-set PF07686.17 PIK35376.1 - 1.6e-14 54.0 0.8 0.00024 21.3 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK35376.1 - 2.8e-09 37.4 1.8 0.0038 17.8 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK35376.1 - 5.3e-06 26.4 0.3 0.088 12.9 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK35376.1 - 0.0011 19.1 0.1 0.39 10.9 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain FAF PF11250.8 PIK35376.1 - 0.013 15.7 0.1 45 4.4 0.0 3.4 3 0 0 3 3 3 0 Fantastic Four meristem regulator DUF4397 PF14344.6 PIK35376.1 - 0.061 14.1 0.1 6.6 7.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4397) DUF1533 PF07550.11 PIK35376.1 - 0.15 11.9 4.3 25 4.9 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1533) V-set PF07686.17 PIK35377.1 - 5.2e-06 26.6 0.6 0.0047 17.1 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK35377.1 - 0.001 19.6 2.7 0.042 14.4 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin domain TMEM154 PF15102.6 PIK35377.1 - 0.0015 18.4 0.0 0.0023 17.8 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family Protocadherin PF08374.11 PIK35377.1 - 0.021 14.8 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 Protocadherin RE_AspBHI_N PF18062.1 PIK35377.1 - 0.047 13.2 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease AspBHI N-terminal Trp_oprn_chp PF09534.10 PIK35377.1 - 0.054 13.3 0.1 0.076 12.8 0.1 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3040 PF11239.8 PIK35377.1 - 0.1 12.9 0.3 0.18 12.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF4366 PF14283.6 PIK35377.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Orf78 PF06024.12 PIK35377.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Cadherin_C_2 PF16492.5 PIK35377.1 - 0.28 11.9 1.0 2.6 8.9 0.0 2.7 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal RCR PF12273.8 PIK35377.1 - 3.8 8.2 6.5 0.61 10.7 0.5 2.6 2 1 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red zf-CCHC PF00098.23 PIK35378.1 - 8.5e-05 22.5 16.5 0.00022 21.2 0.9 3.4 3 0 0 3 3 3 2 Zinc knuckle Bax1-I PF01027.20 PIK35379.1 - 1.9e-16 60.5 13.4 2.3e-16 60.3 13.4 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Pox_E8 PF03394.13 PIK35379.1 - 0.049 13.2 0.2 0.089 12.3 0.1 1.4 1 1 0 1 1 1 0 Poxvirus E8 protein DUF3487 PF11990.8 PIK35379.1 - 0.67 9.9 6.9 0.1 12.5 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Ribosomal_L10 PF00466.20 PIK35380.1 - 1.1e-07 31.9 0.3 2.5e-07 30.7 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 Cation_efflux PF01545.21 PIK35381.1 - 5e-12 46.0 3.5 5e-12 46.0 3.5 2.0 2 0 0 2 2 2 2 Cation efflux family DUF3367 PF11847.8 PIK35381.1 - 0.23 9.3 0.0 0.23 9.3 0.0 1.4 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase Presenilin PF01080.17 PIK35381.1 - 2.5 6.7 10.0 0.33 9.7 5.4 1.7 1 1 1 2 2 2 0 Presenilin RabGAP-TBC PF00566.18 PIK35382.1 - 6.1e-31 107.8 0.0 1.4e-30 106.6 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Tropomyosin PF00261.20 PIK35382.1 - 0.00063 19.2 13.5 0.003 17.0 4.0 2.2 2 0 0 2 2 2 2 Tropomyosin HOOK PF05622.12 PIK35382.1 - 0.002 16.4 17.5 0.035 12.3 6.5 2.2 1 1 1 2 2 2 2 HOOK protein Noelin-1 PF12308.8 PIK35382.1 - 0.23 11.5 7.6 0.08 12.9 2.6 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein Viral_P18 PF04521.13 PIK35382.1 - 0.26 11.1 2.1 1.8 8.3 0.0 2.7 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Lebercilin PF15619.6 PIK35382.1 - 0.3 10.7 18.6 12 5.5 4.3 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF724 PF05266.14 PIK35382.1 - 0.37 10.6 12.6 0.55 10.0 9.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF724) TSC22 PF01166.18 PIK35382.1 - 0.55 10.6 6.2 1.1 9.6 0.1 3.2 1 1 2 3 3 3 0 TSC-22/dip/bun family Fez1 PF06818.15 PIK35382.1 - 1.2 9.6 13.5 3.5 8.0 13.5 1.8 1 1 0 1 1 1 0 Fez1 RabGAP-TBC PF00566.18 PIK35383.1 - 7.5e-05 22.5 0.3 7.5e-05 22.5 0.3 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rootletin PF15035.6 PIK35385.1 - 0.00013 22.0 1.4 0.00019 21.5 1.4 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Cut8 PF08559.10 PIK35385.1 - 0.0047 16.6 1.1 0.0059 16.3 1.1 1.2 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein APG6_N PF17675.1 PIK35385.1 - 0.0054 17.3 7.4 0.0058 17.2 6.7 1.3 1 1 0 1 1 1 1 Apg6 coiled-coil region Filament PF00038.21 PIK35385.1 - 0.0075 15.9 4.7 0.0086 15.7 4.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Flagellar_rod PF05149.12 PIK35385.1 - 0.0076 15.8 2.2 0.0089 15.5 2.2 1.1 1 0 0 1 1 1 1 Paraflagellar rod protein Spc7 PF08317.11 PIK35385.1 - 0.0097 14.8 4.3 0.011 14.7 4.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein FAP206 PF12018.8 PIK35385.1 - 0.011 15.3 0.9 0.011 15.3 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF3053 PF11254.8 PIK35385.1 - 0.011 15.3 0.7 0.013 15.1 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF2968 PF11180.8 PIK35385.1 - 0.017 14.8 2.1 0.019 14.6 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Suppressor_APC PF11414.8 PIK35385.1 - 0.019 15.0 1.4 0.026 14.6 1.3 1.3 1 1 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein DUF724 PF05266.14 PIK35385.1 - 0.022 14.6 5.4 0.026 14.3 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3086 PF11285.8 PIK35385.1 - 0.051 12.7 0.6 0.058 12.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) V_ATPase_I PF01496.19 PIK35385.1 - 0.085 10.8 3.2 0.1 10.5 3.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DHR10 PF18595.1 PIK35385.1 - 0.09 12.8 7.0 0.11 12.5 6.6 1.4 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain NIT PF08376.10 PIK35385.1 - 0.095 13.2 0.3 0.11 12.9 0.3 1.1 1 0 0 1 1 1 0 Nitrate and nitrite sensing SseC PF04888.12 PIK35385.1 - 0.18 11.4 2.8 0.22 11.1 2.8 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF334 PF03904.13 PIK35385.1 - 0.2 11.1 5.1 0.24 10.9 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) CorA PF01544.18 PIK35385.1 - 0.26 10.6 5.6 0.33 10.2 5.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nup88 PF10168.9 PIK35385.1 - 0.26 9.0 5.4 0.26 9.0 5.4 1.0 1 0 0 1 1 1 0 Nuclear pore component GAS PF13851.6 PIK35385.1 - 0.3 10.4 11.6 0.51 9.7 11.6 1.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding ABC_tran_CTD PF16326.5 PIK35385.1 - 0.31 11.3 6.8 0.35 11.1 5.3 1.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF4200 PF13863.6 PIK35385.1 - 0.31 11.4 9.8 0.31 11.4 9.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) TMPIT PF07851.13 PIK35385.1 - 0.59 9.3 2.7 0.69 9.1 2.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4094 PF13334.6 PIK35385.1 - 0.97 9.9 5.0 1.1 9.7 3.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF5320 PF17253.2 PIK35385.1 - 1.5 9.9 3.0 1 10.5 1.5 1.5 2 0 0 2 2 1 0 Family of unknown function (DUF5320) HA2 PF04408.23 PIK35386.1 - 5.9e-22 78.0 0.0 5.9e-22 78.0 0.0 3.5 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK35386.1 - 1.6e-20 73.2 0.0 3.9e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK35386.1 - 3e-14 53.3 0.0 8.1e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK35386.1 - 2.1e-06 27.6 0.0 5.6e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK35386.1 - 9.5e-05 22.7 0.0 0.00044 20.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK35386.1 - 0.0004 20.2 0.0 0.001 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK35386.1 - 0.00074 18.6 0.0 0.002 17.2 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein PWI PF01480.17 PIK35386.1 - 0.0032 17.8 0.1 0.0097 16.2 0.1 1.9 1 0 0 1 1 1 1 PWI domain AAA_19 PF13245.6 PIK35386.1 - 0.0045 17.3 1.3 0.03 14.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 PIK35386.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain SRP54 PF00448.22 PIK35386.1 - 0.059 13.0 0.1 0.18 11.4 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain DAO PF01266.24 PIK35387.1 - 3.3e-27 96.0 0.0 4.7e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF3987 PF13148.6 PIK35388.1 - 1 8.3 6.7 2.1 7.3 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) PIN_12 PF16289.5 PIK35388.1 - 4.4 7.8 8.4 22 5.5 0.1 2.4 2 0 0 2 2 2 0 PIN domain EMC3_TMCO1 PF01956.16 PIK35388.1 - 8.5 6.1 5.0 18 5.0 5.0 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like IQ PF00612.27 PIK35389.1 - 0.001 18.6 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Exonuc_VII_L PF02601.15 PIK35390.1 - 1.2 8.6 11.3 2 7.9 11.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Borrelia_P83 PF05262.11 PIK35390.1 - 6.8 5.1 9.8 9.7 4.5 9.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CAP_GLY PF01302.25 PIK35391.1 - 4.3e-18 65.1 0.1 7.3e-18 64.4 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF4378 PF14309.6 PIK35392.1 - 0.00042 20.7 0.8 0.00087 19.7 0.8 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4378) Ephrin_rec_like PF07699.13 PIK35393.1 - 0.0047 16.7 13.3 0.067 13.0 3.3 3.6 1 1 2 3 3 3 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK35393.1 - 0.011 15.6 7.7 0.1 12.6 0.4 2.9 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR DUF21 PF01595.20 PIK35393.1 - 0.13 11.9 4.4 4.6 6.9 1.7 2.5 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain LRR_8 PF13855.6 PIK35394.1 - 0.0015 18.3 0.1 0.018 14.8 0.1 2.3 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 PIK35394.1 - 0.088 13.3 0.3 0.56 10.7 0.1 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) E7 PF00527.18 PIK35395.1 - 1.2 9.3 8.5 5.1 7.4 0.0 3.7 3 1 0 3 3 3 0 E7 protein, Early protein DUF4572 PF15139.6 PIK35396.1 - 4.4e-63 212.7 1.3 5.3e-63 212.5 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4572) DUF2333 PF10095.9 PIK35396.1 - 0.17 10.9 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Homeodomain PF00046.29 PIK35397.1 - 3.7e-20 71.5 1.9 6.4e-20 70.8 1.9 1.4 1 0 0 1 1 1 1 Homeodomain Raftlin PF15250.6 PIK35398.1 - 0.03 13.1 0.0 0.039 12.7 0.0 1.1 1 0 0 1 1 1 0 Raftlin zf-RING_5 PF14634.6 PIK35399.1 - 2.8e-08 33.6 9.2 5.1e-08 32.8 9.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK35399.1 - 2e-07 31.2 9.7 3.4e-07 30.5 9.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK35399.1 - 4.1e-07 29.9 9.0 8.7e-07 28.9 9.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK35399.1 - 7.3e-07 29.0 9.9 1.6e-06 27.9 9.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35399.1 - 5.4e-06 26.2 10.9 1.2e-05 25.0 10.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK35399.1 - 0.00014 21.9 10.4 0.0003 20.9 10.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 PIK35399.1 - 0.0012 18.6 8.6 0.0022 17.7 8.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Methyltrans_RNA PF04452.14 PIK35399.1 - 0.0056 16.1 0.2 0.015 14.7 0.2 1.7 1 0 0 1 1 1 1 RNA methyltransferase Angiomotin_C PF12240.8 PIK35399.1 - 0.0057 16.2 3.8 0.0077 15.8 3.8 1.1 1 0 0 1 1 1 1 Angiomotin C terminal DUF5338 PF17273.2 PIK35399.1 - 0.045 13.8 0.5 0.15 12.1 0.2 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5338) RapA_C PF12137.8 PIK35399.1 - 0.12 11.3 5.2 0.17 10.9 5.2 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Prok-RING_4 PF14447.6 PIK35399.1 - 0.85 9.5 12.2 13 5.7 12.9 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK35399.1 - 1.3 8.8 8.1 0.31 10.8 4.5 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 PIK35399.1 - 1.4 9.3 10.6 7.6 6.9 10.6 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain NHL PF01436.21 PIK35400.1 - 1.4e-41 138.5 10.1 7.1e-08 32.1 1.6 5.6 5 0 0 5 5 5 5 NHL repeat DUF5128 PF17170.4 PIK35400.1 - 2e-14 53.5 0.1 0.00013 21.2 0.1 3.5 1 1 3 4 4 4 3 6-bladed beta-propeller SGL PF08450.12 PIK35400.1 - 3.5e-13 49.7 0.4 0.00021 20.9 0.1 4.2 1 1 2 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region DUF4934 PF16288.5 PIK35400.1 - 5.6e-07 29.4 1.8 0.0091 15.9 0.0 3.4 1 1 3 4 4 4 3 Domain of unknown function (DUF4934) SBBP PF06739.11 PIK35400.1 - 1.1e-06 28.5 0.1 0.017 15.1 0.1 3.5 3 0 0 3 3 3 2 Beta-propeller repeat SdiA-regulated PF06977.11 PIK35400.1 - 0.027 13.7 0.0 42 3.2 0.0 3.9 4 0 0 4 4 4 0 SdiA-regulated Phytase-like PF13449.6 PIK35400.1 - 0.04 13.9 0.0 19 5.1 0.0 4.0 1 1 2 3 3 3 0 Esterase-like activity of phytase Strep_pep PF14404.6 PIK35400.1 - 0.16 12.3 0.0 0.45 10.8 0.0 1.7 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species DNA_primase_lrg PF04104.14 PIK35401.1 - 1.4e-91 306.6 0.1 1.4e-91 306.6 0.1 1.4 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit LisH_TPL PF17814.1 PIK35401.1 - 0.09 12.4 0.0 0.8 9.4 0.0 2.4 2 0 0 2 2 2 0 LisH-like dimerisation domain ADH_zinc_N PF00107.26 PIK35402.1 - 1.5e-11 44.4 0.0 3.1e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK35402.1 - 3.9e-06 26.7 0.0 1.2e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ATG16 PF08614.11 PIK35403.1 - 0.12 12.6 0.2 0.12 12.6 0.2 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HTH_32 PF13565.6 PIK35403.1 - 1.9 9.2 5.4 6 7.6 1.6 3.0 2 1 1 3 3 3 0 Homeodomain-like domain NapB PF03892.14 PIK35405.1 - 2.7 8.0 13.5 52 3.9 0.1 6.0 6 0 0 6 6 6 0 Nitrate reductase cytochrome c-type subunit (NapB) Tektin PF03148.14 PIK35408.1 - 2.3e-147 490.7 30.5 2.7e-147 490.5 30.5 1.0 1 0 0 1 1 1 1 Tektin family Snapin_Pallidin PF14712.6 PIK35408.1 - 0.053 13.9 1.1 0.053 13.9 1.1 4.2 4 0 0 4 4 4 0 Snapin/Pallidin CENP-F_leu_zip PF10473.9 PIK35408.1 - 0.093 12.7 27.9 0.032 14.2 2.3 4.2 2 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MitMem_reg PF13012.6 PIK35408.1 - 1.3 9.4 12.4 1.2 9.6 0.2 4.1 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function BLOC1_2 PF10046.9 PIK35408.1 - 1.3 9.3 13.4 0.92 9.8 0.4 3.9 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rab5-bind PF09311.11 PIK35408.1 - 3 7.1 29.3 0.2 11.0 2.4 3.9 2 2 2 4 4 4 0 Rabaptin-like protein CdvA PF18822.1 PIK35408.1 - 3.1 7.6 14.8 4.3 7.2 0.3 3.9 4 0 0 4 4 4 0 CdvA-like coiled-coil domain V_ATPase_I PF01496.19 PIK35408.1 - 3.5 5.4 16.8 0.019 13.0 2.4 2.4 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 PIK35408.1 - 3.7 7.6 18.9 9.5 6.3 1.7 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) RVT_1 PF00078.27 PIK35409.1 - 1.4e-34 119.5 0.1 2.7e-34 118.6 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK35409.1 - 2e-31 108.0 0.0 4.6e-31 106.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35409.1 - 8.2e-29 100.0 0.0 4.1e-28 97.7 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK35409.1 - 3.3e-20 72.5 0.0 6.9e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK35409.1 - 9.1e-18 64.1 0.0 2.6e-17 62.6 0.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain PNMA PF14893.6 PIK35409.1 - 2.3e-10 40.4 0.0 4.6e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.23 PIK35409.1 - 3.2e-06 26.9 0.6 3.2e-06 26.9 0.6 2.9 2 0 0 2 2 2 1 Zinc knuckle RRM_1 PF00076.22 PIK35409.1 - 1.3e-05 24.9 0.0 3.8e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) rve_3 PF13683.6 PIK35409.1 - 1.6e-05 24.6 0.0 4.7e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK35409.1 - 0.00022 21.4 1.1 0.00048 20.3 0.0 2.3 2 0 0 2 2 1 1 H2C2 zinc finger gag-asp_proteas PF13975.6 PIK35409.1 - 0.00048 20.6 0.0 0.0016 19.0 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK35409.1 - 0.0033 18.0 0.0 0.0093 16.6 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.6 PIK35409.1 - 0.0062 16.3 0.3 0.014 15.2 0.3 1.6 1 0 0 1 1 1 1 Zinc knuckle dUTPase PF00692.19 PIK35409.1 - 0.081 12.6 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 dUTPase zf-CCHC_6 PF15288.6 PIK35409.1 - 0.44 10.4 6.4 2 8.4 6.4 2.1 1 0 0 1 1 1 0 Zinc knuckle dsrm PF00035.26 PIK35410.1 - 0.00017 22.2 0.1 0.0004 21.0 0.1 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Pox_Ag35 PF03286.14 PIK35410.1 - 0.00042 20.2 15.0 0.00042 20.2 15.0 2.1 1 1 1 2 2 2 1 Pox virus Ag35 surface protein Dicer_dimer PF03368.14 PIK35410.1 - 0.0015 18.7 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain Nop14 PF04147.12 PIK35410.1 - 0.093 10.9 23.2 0.14 10.4 23.2 1.3 1 0 0 1 1 1 0 Nop14-like family DUF656 PF04920.12 PIK35410.1 - 0.095 12.6 1.0 0.84 9.6 0.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF656) PBP1_TM PF14812.6 PIK35410.1 - 0.12 12.8 13.7 0.39 11.1 5.1 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DAP PF15228.6 PIK35410.1 - 0.14 13.4 4.7 0.36 12.0 1.7 2.7 2 0 0 2 2 2 0 Death-associated protein CENP-B_dimeris PF09026.10 PIK35410.1 - 0.27 11.6 15.0 0.28 11.6 11.5 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RR_TM4-6 PF06459.12 PIK35410.1 - 4 7.2 20.0 0.8 9.5 16.6 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Cytomega_UL84 PF06284.11 PIK35410.1 - 4.7 5.6 7.8 8.8 4.7 7.8 1.5 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF4746 PF15928.5 PIK35410.1 - 8.9 5.6 15.4 5 6.5 13.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) FHA PF00498.26 PIK35411.1 - 3.2e-12 46.6 0.0 1.2e-11 44.7 0.0 2.0 2 1 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 PIK35411.1 - 0.0001 22.5 0.0 0.00044 20.5 0.0 2.2 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain C1ORF64 PF15547.6 PIK35411.1 - 0.65 10.5 4.0 0.76 10.2 2.0 1.9 1 1 1 2 2 2 0 Steroid receptor-associated and regulated protein ATP-gua_Ptrans PF00217.19 PIK35412.1 - 1e-58 198.4 0.1 1.2e-58 198.1 0.1 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain Ribosomal_60s PF00428.19 PIK35412.1 - 0.088 13.4 3.2 0.16 12.6 3.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein FAP PF07174.11 PIK35412.1 - 0.31 10.5 8.4 0.43 10.0 8.4 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) MSA-2c PF12238.8 PIK35412.1 - 3.6 7.5 5.7 4.9 7.1 5.7 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c ATP-gua_PtransN PF02807.15 PIK35413.1 - 7.4e-27 93.5 0.0 1.3e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.19 PIK35413.1 - 1.8e-07 30.8 0.0 2.9e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain MOZ_SAS PF01853.18 PIK35414.1 - 5.7e-82 273.7 0.2 8.5e-82 273.1 0.2 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 PIK35414.1 - 3.9e-21 74.4 3.9 3.9e-21 74.4 3.9 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 PIK35414.1 - 1.4e-19 69.7 0.1 2.8e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 PIK35414.1 - 0.01 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK35414.1 - 0.16 12.2 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family SSF PF00474.17 PIK35415.1 - 2.2e-44 152.0 30.9 2.2e-44 152.0 30.9 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family Rick_17kDa_Anti PF05433.15 PIK35415.1 - 1.1 9.1 4.1 1.3 8.9 2.3 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 PIK35415.1 - 8.5 6.5 6.7 18 5.4 2.6 2.5 1 1 1 2 2 2 0 Glycine zipper UPF0767 PF15990.5 PIK35416.1 - 1e-32 112.1 0.0 1.1e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 UPF0767 family SAM_4 PF18017.1 PIK35417.1 - 3.3e-28 97.5 0.1 5.9e-28 96.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5577 PF17740.1 PIK35417.1 - 1.1e-05 25.3 18.9 0.0011 18.8 0.6 3.4 1 1 1 3 3 3 2 Family of unknown function (DUF5577) SAM_2 PF07647.17 PIK35417.1 - 0.0037 17.3 0.0 0.0078 16.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK35417.1 - 0.0071 16.8 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5614 PF18474.1 PIK35417.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5614) FHA PF00498.26 PIK35418.1 - 4e-11 43.1 0.0 8.6e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-C3HC4_3 PF13920.6 PIK35418.1 - 1.5e-09 37.6 7.7 1.5e-09 37.6 7.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35418.1 - 2.2e-09 37.0 10.4 2.2e-09 37.0 10.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK35418.1 - 2.2e-08 33.8 11.0 5.5e-08 32.5 11.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK35418.1 - 4.6e-08 33.3 9.9 4.6e-08 33.3 9.9 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK35418.1 - 1.8e-06 27.8 2.6 1.8e-06 27.8 2.6 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK35418.1 - 7.2e-06 25.9 9.3 7.2e-06 25.9 9.3 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 PIK35418.1 - 4.3e-05 23.7 9.0 0.00018 21.7 9.0 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 PIK35418.1 - 9.4e-05 22.5 9.8 0.00024 21.2 9.8 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Yop-YscD_cpl PF16697.5 PIK35418.1 - 0.00063 20.0 0.0 0.0027 18.0 0.0 2.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_10 PF16685.5 PIK35418.1 - 0.001 19.1 4.7 0.0026 17.9 4.7 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 PIK35418.1 - 0.0016 18.3 3.0 0.0041 17.0 3.0 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein NOA36 PF06524.12 PIK35418.1 - 0.0051 16.2 8.2 0.0051 16.2 8.2 2.3 2 1 1 3 3 3 1 NOA36 protein Prok-RING_4 PF14447.6 PIK35418.1 - 0.0075 16.1 6.8 0.0075 16.1 6.8 1.7 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-CCHC PF00098.23 PIK35418.1 - 0.014 15.5 3.7 0.014 15.5 3.7 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-ANAPC11 PF12861.7 PIK35418.1 - 0.097 12.7 6.6 0.13 12.3 4.7 2.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger TP1 PF02079.16 PIK35418.1 - 0.16 11.9 0.5 0.67 9.9 0.5 2.0 1 0 0 1 1 1 0 Nuclear transition protein 1 zf-Nse PF11789.8 PIK35418.1 - 0.47 10.3 6.1 1.9 8.3 6.1 2.2 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit YqjK PF13997.6 PIK35418.1 - 0.48 10.7 3.2 2.3 8.5 1.4 2.2 2 0 0 2 2 2 0 YqjK-like protein zf-CCHC_4 PF14392.6 PIK35418.1 - 0.68 9.7 5.8 0.13 12.0 0.9 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-RING_4 PF14570.6 PIK35418.1 - 0.96 9.3 7.2 3 7.7 7.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 PIK35418.1 - 1 9.1 6.7 2.4 7.9 6.7 1.6 1 0 0 1 1 1 0 P-11 zinc finger RLL PF10036.9 PIK35419.1 - 1e-79 268.0 0.9 1.2e-79 267.8 0.9 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein OATP PF03137.20 PIK35420.1 - 5.2e-24 84.4 0.8 6.3e-24 84.2 0.8 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK35420.1 - 0.032 13.2 10.6 0.012 14.6 5.4 2.0 2 0 0 2 2 2 0 Major Facilitator Superfamily OATP PF03137.20 PIK35421.1 - 3.3e-71 240.2 8.8 4.9e-71 239.7 8.8 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK35421.1 - 1.3e-10 40.8 5.9 7.5e-08 31.7 4.4 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK35421.1 - 7.9e-07 29.1 9.7 2e-06 27.8 9.7 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK35421.1 - 7.5e-05 22.7 2.5 0.00018 21.5 2.5 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain SIT PF15330.6 PIK35421.1 - 0.058 13.8 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Pam17 PF08566.10 PIK35421.1 - 0.35 10.7 0.9 1.2 8.9 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 RVT_3 PF13456.6 PIK35423.1 - 0.051 13.4 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like USP7_ICP0_bdg PF12436.8 PIK35425.1 - 9.1e-72 241.2 0.4 4.4e-71 239.0 0.0 2.2 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 PIK35425.1 - 8.6e-57 192.2 2.3 4.7e-56 189.8 1.0 2.5 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 PIK35425.1 - 9.4e-51 172.8 0.7 1.6e-50 172.0 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK35425.1 - 1.1e-23 84.3 0.0 2.6e-23 83.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 PIK35425.1 - 5.4e-20 71.6 0.3 2.7e-19 69.4 0.2 2.2 2 0 0 2 2 2 1 MATH domain Il2rg PF15874.5 PIK35425.1 - 0.048 13.9 0.2 1.9 8.8 0.1 2.6 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain DUF1402 PF07182.11 PIK35425.1 - 0.18 10.9 0.7 0.65 9.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1402) 7tm_1 PF00001.21 PIK35427.1 - 3.7e-32 111.7 7.5 8.6e-32 110.5 7.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35427.1 - 7.3e-08 32.4 14.3 7.3e-08 32.4 14.3 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK35427.1 - 1.1e-06 28.2 5.9 0.00018 21.0 4.1 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv DUF2740 PF10872.8 PIK35427.1 - 0.028 14.3 0.3 0.089 12.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) RVT_1 PF00078.27 PIK35428.1 - 1.6e-07 31.1 0.0 2.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Death PF00531.22 PIK35429.1 - 2.8e-13 49.9 0.7 6.3e-13 48.7 0.7 1.6 1 0 0 1 1 1 1 Death domain EF_assoc_2 PF08356.12 PIK35429.1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 EF hand associated Fez1 PF06818.15 PIK35430.1 - 0.0078 16.7 25.0 0.0078 16.7 25.0 4.7 1 1 3 4 4 4 2 Fez1 Requiem_N PF14051.6 PIK35431.1 - 0.0061 16.7 0.1 0.018 15.2 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.29 PIK35432.1 - 5.3e-15 55.0 28.6 3.7e-09 36.4 8.1 2.4 1 1 1 2 2 2 2 PHD-finger PHD_2 PF13831.6 PIK35432.1 - 0.0014 18.1 0.7 0.0014 18.1 0.7 2.8 2 1 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 PIK35432.1 - 0.18 11.4 12.4 0.5 10.0 3.1 2.6 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain PHD_4 PF16866.5 PIK35432.1 - 1 9.5 27.4 0.076 13.1 14.8 3.1 1 1 1 2 2 2 0 PHD-finger Ion_trans PF00520.31 PIK35433.1 - 7.8e-26 90.8 25.1 1.1e-25 90.4 25.1 1.2 1 0 0 1 1 1 1 Ion transport protein SH3_2 PF07653.17 PIK35433.1 - 4.1e-11 42.4 0.1 8.2e-11 41.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK35433.1 - 1.9e-10 40.2 0.1 3.7e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK35433.1 - 5e-10 39.1 0.0 9.2e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_5 PF13202.6 PIK35433.1 - 0.026 14.0 0.1 0.24 11.0 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 PIK35433.1 - 0.057 13.9 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 PIK35433.1 - 0.078 12.6 0.0 0.61 9.8 0.0 2.6 2 0 0 2 2 2 0 EF hand YMF19 PF02326.15 PIK35433.1 - 0.39 11.5 1.7 3.6 8.4 0.1 3.1 2 0 0 2 2 2 0 Plant ATP synthase F0 DUF3713 PF12506.8 PIK35433.1 - 4.7 7.5 7.2 4.2 7.7 3.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) RT_RNaseH_2 PF17919.1 PIK35434.1 - 0.17 12.0 0.0 0.7 10.0 0.0 1.9 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase MORN PF02493.20 PIK35435.1 - 3.5e-17 61.2 17.5 3.7e-05 23.4 0.1 5.1 5 0 0 5 5 5 4 MORN repeat PATR PF12951.7 PIK35435.1 - 0.06 13.5 1.1 0.18 12.0 1.1 1.8 1 0 0 1 1 1 0 Passenger-associated-transport-repeat Tudor_1_RapA PF18339.1 PIK35436.1 - 0.12 12.4 17.4 95 3.1 0.0 8.9 5 3 6 11 11 11 0 RapA N-terminal Tudor like domain 1 Tudor_1_RapA PF18339.1 PIK35437.1 - 0.21 11.6 14.3 76 3.4 0.0 7.2 1 1 8 9 9 9 0 RapA N-terminal Tudor like domain 1 ANF_receptor PF01094.28 PIK35438.1 - 1.4e-12 47.4 0.0 1.6e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK35438.1 - 0.12 12.0 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Periplasmic binding protein ANF_receptor PF01094.28 PIK35439.1 - 1.6e-14 53.8 0.0 1.9e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK35439.1 - 0.026 14.2 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Kazal_1 PF00050.21 PIK35441.1 - 2e-125 408.7 185.5 4.7e-09 36.1 5.5 15.9 7 5 8 15 15 15 15 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK35441.1 - 3.1e-116 379.4 207.4 3.9e-08 33.3 7.2 15.6 14 1 1 15 15 15 15 Kazal-type serine protease inhibitor domain Defensin_big PF14862.6 PIK35441.1 - 1.4e-11 44.5 62.0 1.6 9.1 0.2 14.5 14 0 0 14 14 14 9 Big defensin Complex1_51K PF01512.17 PIK35441.1 - 0.006 16.5 10.4 19 5.1 0.0 6.7 4 3 4 8 8 8 2 Respiratory-chain NADH dehydrogenase 51 Kd subunit Kazal_1 PF00050.21 PIK35442.1 - 2.1e-09 37.2 0.8 4.8e-09 36.1 0.8 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK35442.1 - 2.3e-08 34.1 1.3 5.4e-08 32.8 1.3 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Fra10Ac1 PF09725.9 PIK35443.1 - 3.8e-49 165.9 5.0 8.1e-49 164.9 5.0 1.5 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 AP3D1 PF06375.11 PIK35443.1 - 0.0015 18.8 13.8 0.0022 18.3 13.8 1.3 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 SelP_N PF04592.14 PIK35443.1 - 0.0024 17.3 10.1 0.004 16.6 10.1 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region DUF755 PF05501.11 PIK35443.1 - 0.027 14.7 23.2 0.042 14.1 23.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SAPS PF04499.15 PIK35443.1 - 0.028 13.2 3.8 0.028 13.2 3.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SpoIIIAH PF12685.7 PIK35443.1 - 0.038 13.8 7.4 0.053 13.3 7.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Phage_holin_2_3 PF16080.5 PIK35443.1 - 0.068 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage holin family HP1 DUF3492 PF11997.8 PIK35443.1 - 0.078 12.7 4.2 0.13 12.0 3.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) DDHD PF02862.17 PIK35443.1 - 0.16 12.1 3.7 0.18 11.9 3.7 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 PIK35443.1 - 0.2 11.7 2.6 0.22 11.5 2.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2387 PF09526.10 PIK35443.1 - 0.3 11.3 6.0 1.4 9.1 4.0 2.6 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) DUF913 PF06025.12 PIK35443.1 - 1.2 8.1 5.3 1.4 7.8 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 PIK35443.1 - 1.2 7.8 5.9 1.4 7.6 5.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Atrophin-1 PF03154.15 PIK35443.1 - 3.3 5.9 13.3 4.1 5.6 13.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family PPL5 PF18168.1 PIK35443.1 - 3.8 6.7 10.7 5.1 6.3 10.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RP-C_C PF11800.8 PIK35443.1 - 6.9 6.7 9.0 9.6 6.2 9.0 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region CTU2 PF10288.9 PIK35443.1 - 8.1 6.7 13.6 28 5.0 13.6 2.0 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Presenilin PF01080.17 PIK35443.1 - 8.3 5.1 12.8 11 4.7 12.8 1.1 1 0 0 1 1 1 0 Presenilin CH_2 PF06294.11 PIK35444.1 - 1.5e-32 111.5 0.0 3e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 PIK35444.1 - 5.3e-15 55.0 0.0 1.4e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain RFXA_RFXANK_bdg PF15289.6 PIK35444.1 - 0.025 14.9 0.3 0.046 14.1 0.3 1.5 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain CH PF00307.31 PIK35444.1 - 0.054 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Calponin homology (CH) domain Nup84_Nup100 PF04121.13 PIK35445.1 - 5.2e-111 372.0 3.1 6.3e-111 371.7 3.1 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Fz PF01392.22 PIK35445.1 - 0.079 13.6 1.7 0.75 10.4 0.3 2.7 3 0 0 3 3 3 0 Fz domain p450 PF00067.22 PIK35446.1 - 2e-20 73.0 0.0 2e-19 69.7 0.0 1.9 2 0 0 2 2 2 2 Cytochrome P450 UDG PF03167.19 PIK35447.1 - 1.8e-26 93.0 0.0 3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily UDG PF03167.19 PIK35448.1 - 2.8e-16 59.9 0.0 8.2e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily Mitofilin PF09731.9 PIK35449.1 - 1.6e-86 291.6 43.4 2.1e-86 291.2 43.4 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein MgpC PF05220.12 PIK35449.1 - 0.092 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 MgpC protein precursor Caskin-Pro-rich PF16907.5 PIK35449.1 - 0.78 10.3 5.3 0.32 11.6 1.6 2.3 2 0 0 2 2 2 0 Proline rich region of Caskin proteins DPCD PF14913.6 PIK35450.1 - 1.6e-82 275.5 1.6 1.8e-82 275.4 1.6 1.0 1 0 0 1 1 1 1 DPCD protein family G-gamma PF00631.22 PIK35451.1 - 4.7e-14 52.1 0.0 6.1e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 GGL domain DUF716 PF04819.12 PIK35453.1 - 6.1e-28 97.2 5.6 1.2e-27 96.2 5.6 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) Ephrin_rec_like PF07699.13 PIK35455.1 - 7.9e-07 28.7 35.2 9.7e-06 25.3 5.3 5.4 2 2 2 4 4 4 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK35455.1 - 0.01 15.8 27.0 0.031 14.2 1.1 5.1 4 1 0 4 4 4 0 Nine Cysteines Domain of family 3 GPCR GDP_Man_Dehyd PF16363.5 PIK35456.1 - 5.8e-57 193.6 0.0 1.4e-56 192.3 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK35456.1 - 3.7e-50 170.6 0.0 5.2e-50 170.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK35456.1 - 1.1e-09 37.7 0.0 1.7e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 PIK35456.1 - 2e-09 37.0 0.0 0.00022 20.5 0.0 2.3 1 1 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 PIK35456.1 - 4e-09 36.0 0.0 6e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 PIK35456.1 - 9.7e-08 31.5 0.5 0.00063 19.0 0.0 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein adh_short PF00106.25 PIK35456.1 - 0.035 13.6 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.6 PIK35456.1 - 0.046 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding UXS1_N PF11803.8 PIK35456.1 - 0.062 13.7 1.5 0.26 11.7 0.1 2.4 2 0 0 2 2 2 0 UDP-glucuronate decarboxylase N-terminal NAD_binding_7 PF13241.6 PIK35456.1 - 0.12 12.8 0.0 0.48 10.9 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding KR PF08659.10 PIK35456.1 - 0.17 11.7 0.0 0.47 10.3 0.0 1.7 2 0 0 2 2 2 0 KR domain PARG_cat PF05028.14 PIK35457.1 - 8.5e-23 81.2 0.4 1.3e-22 80.5 0.4 1.3 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Ribosomal_S24e PF01282.19 PIK35458.1 - 1.8e-39 133.6 0.2 3.8e-39 132.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e rve PF00665.26 PIK35459.1 - 0.041 14.1 0.0 0.061 13.5 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Vsr PF03852.15 PIK35460.1 - 0.0018 18.1 0.4 0.0081 16.0 0.2 2.2 3 0 0 3 3 3 1 DNA mismatch endonuclease Vsr zf-CCHC PF00098.23 PIK35461.1 - 6.2e-07 29.2 15.8 0.00069 19.6 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK35461.1 - 0.00084 19.1 8.2 0.11 12.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35461.1 - 0.023 14.5 0.2 0.023 14.5 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK35461.1 - 0.023 14.4 0.8 0.023 14.4 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK35461.1 - 0.042 13.6 11.1 5.2 6.9 0.3 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK35461.1 - 0.074 13.0 16.5 0.25 11.3 1.2 3.5 2 1 2 4 4 4 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK35462.1 - 5.1e-08 32.7 0.0 9.1e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 PIK35462.1 - 8.6e-05 22.4 15.2 0.0048 16.9 3.3 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35462.1 - 9.2e-05 22.2 6.3 0.0043 16.9 0.2 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35462.1 - 0.00035 20.2 14.3 0.42 10.4 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK35462.1 - 3.1 8.1 12.0 0.65 10.3 6.0 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 PIK35463.1 - 2.8e-34 118.6 0.0 3.5e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK35464.1 - 1.5e-07 32.0 3.6 1.5e-07 32.0 3.6 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase INCENP_ARK-bind PF03941.15 PIK35467.1 - 4e-14 52.3 2.3 1e-13 51.0 0.1 2.8 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region RFX5_DNA_bdg PF14621.6 PIK35468.1 - 0.00011 22.0 1.8 0.00014 21.7 1.8 1.3 1 0 0 1 1 1 1 RFX5 DNA-binding domain INCENP_N PF12178.8 PIK35468.1 - 0.0037 17.3 2.3 0.0054 16.7 2.3 1.2 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal DTHCT PF08070.11 PIK35468.1 - 0.016 15.9 6.1 0.02 15.6 6.1 1.2 1 0 0 1 1 1 0 DTHCT (NUC029) region Anoct_dimer PF16178.5 PIK35469.1 - 1.1e-11 44.9 2.6 1.1e-11 44.9 2.6 1.4 2 0 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Sugar_tr PF00083.24 PIK35470.1 - 5.2e-25 88.2 2.1 6.1e-25 88.0 2.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK35470.1 - 4e-18 65.5 8.2 5.1e-18 65.1 8.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4605 PF15378.6 PIK35470.1 - 0.069 13.0 1.1 0.18 11.7 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) MFS_1 PF07690.16 PIK35471.1 - 6.5e-10 38.5 4.3 8.4e-10 38.1 4.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily BBS1 PF14779.6 PIK35471.1 - 0.19 11.1 0.0 0.35 10.3 0.0 1.4 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 1 Alpha_adaptinC2 PF02883.20 PIK35472.1 - 3.4e-23 82.0 1.0 7.8e-23 80.9 1.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain VHS PF00790.19 PIK35473.1 - 2.6e-38 131.1 0.8 6.5e-38 129.8 0.0 1.9 2 0 0 2 2 2 1 VHS domain GGA_N-GAT PF18308.1 PIK35473.1 - 9.3e-20 70.0 7.1 3.6e-19 68.1 7.1 2.1 1 0 0 1 1 1 1 GGA N-GAT domain GAT PF03127.14 PIK35473.1 - 1.6e-17 63.6 4.4 2e-17 63.2 0.2 2.6 2 0 0 2 2 2 1 GAT domain FliT PF05400.13 PIK35473.1 - 0.98 10.3 4.4 2 9.3 0.1 3.0 3 1 0 3 3 3 0 Flagellar protein FliT SHMT PF00464.19 PIK35474.1 - 2.1e-193 642.4 0.0 2.4e-193 642.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 PIK35474.1 - 0.00079 18.7 0.0 0.0014 17.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1104 PF06518.11 PIK35474.1 - 0.11 12.9 1.3 0.47 10.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) RVT_1 PF00078.27 PIK35477.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_1 PF00133.22 PIK35479.1 - 1.1e-52 179.2 0.0 1.3e-52 178.9 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 PIK35479.1 - 0.00043 19.7 0.0 0.00054 19.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 PIK35479.1 - 0.0012 17.6 0.0 0.0015 17.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) DUF3364 PF11844.8 PIK35479.1 - 0.068 13.4 1.0 0.14 12.5 0.0 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3364) tRNA-synt_1 PF00133.22 PIK35480.1 - 5e-37 127.4 4.6 1.5e-27 96.2 0.1 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1 PF00133.22 PIK35481.1 - 1e-78 265.1 0.0 1.3e-78 264.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 PIK35481.1 - 6.9e-07 28.4 0.1 2.3e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (M) Kelch_4 PF13418.6 PIK35482.1 - 6.8e-28 96.4 5.2 2.1e-07 30.8 0.4 5.3 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK35482.1 - 1.4e-23 82.4 4.6 1.7e-06 27.9 0.0 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 PIK35482.1 - 3e-22 77.9 3.5 1.9e-05 24.2 0.1 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 PIK35482.1 - 3.8e-21 74.9 6.6 1.7e-06 28.2 0.0 5.4 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK35482.1 - 8.1e-19 67.2 9.4 3.9e-07 30.1 0.0 5.7 4 2 2 6 6 6 4 Kelch motif Kelch_2 PF07646.15 PIK35482.1 - 2.5e-17 62.1 8.1 0.00058 19.7 0.0 5.5 5 0 0 5 5 5 3 Kelch motif PQQ_3 PF13570.6 PIK35482.1 - 0.14 12.7 0.2 38 5.0 0.0 3.8 5 0 0 5 5 5 0 PQQ-like domain EamA PF00892.20 PIK35483.1 - 1.2e-09 38.5 7.8 1.2e-09 38.5 7.8 1.9 2 0 0 2 2 2 1 EamA-like transporter family Allene_ox_cyc PF06351.11 PIK35483.1 - 0.082 12.7 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Allene oxide cyclase F-112 PF09645.10 PIK35484.1 - 0.012 15.6 2.6 1.2 9.3 0.2 2.6 1 1 1 2 2 2 0 F-112 protein IMPDH PF00478.25 PIK35485.1 - 2.1e-21 76.3 0.1 2.5e-21 76.1 0.1 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain IMPDH PF00478.25 PIK35486.1 - 4.5e-69 233.1 0.6 5e-69 232.9 0.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 PIK35486.1 - 3.8e-12 46.5 0.3 6.2e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 PIK35486.1 - 3.1e-05 23.5 0.5 0.0018 17.7 0.0 2.3 2 1 0 2 2 2 1 Nitronate monooxygenase Aldolase PF01081.19 PIK35486.1 - 0.0017 17.9 0.2 0.0031 16.9 0.2 1.4 1 0 0 1 1 1 1 KDPG and KHG aldolase BATS PF06968.13 PIK35486.1 - 0.018 15.2 0.0 0.38 10.9 0.0 2.5 1 1 1 2 2 2 0 Biotin and Thiamin Synthesis associated domain UvrA_inter PF17760.1 PIK35486.1 - 0.056 13.5 0.3 6.4 6.9 0.0 2.5 2 0 0 2 2 2 0 UvrA interaction domain B12-binding PF02310.19 PIK35486.1 - 0.07 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 B12 binding domain QRPTase_C PF01729.19 PIK35486.1 - 0.096 12.5 0.3 0.17 11.6 0.3 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain PcrB PF01884.17 PIK35486.1 - 0.31 10.5 2.3 23 4.3 0.0 3.3 1 1 2 3 3 3 0 PcrB family Gemini_AC4_5 PF04807.12 PIK35488.1 - 0.0013 18.3 12.6 4.2e+02 0.7 0.0 11.5 8 4 9 17 17 17 0 Geminivirus AC4/5 conserved region Ribosomal_L2 PF00181.23 PIK35488.1 - 0.0029 17.5 24.5 80 3.3 0.3 11.5 3 2 4 9 9 9 0 Ribosomal Proteins L2, RNA binding domain GAIN_A PF18619.1 PIK35488.1 - 0.004 17.3 9.5 59 4.0 0.1 7.2 3 2 2 6 6 6 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A MHC_II_alpha PF00993.20 PIK35488.1 - 0.088 12.5 0.1 1.4e+02 2.2 0.0 4.9 3 2 1 5 5 5 0 Class II histocompatibility antigen, alpha domain L27 PF02828.16 PIK35488.1 - 0.27 11.0 3.9 49 3.8 0.1 5.4 5 1 0 5 5 5 0 L27 domain ANF_receptor PF01094.28 PIK35489.1 - 2.4e-34 119.0 0.0 3e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Rab5ip PF07019.12 PIK35489.1 - 0.13 12.9 0.3 0.24 12.0 0.3 1.4 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) ANF_receptor PF01094.28 PIK35490.1 - 2.1e-20 73.1 0.0 2.4e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK35490.1 - 0.0002 21.1 0.0 0.00022 21.0 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Bmp PF02608.14 PIK35490.1 - 0.021 13.8 0.1 0.026 13.5 0.1 1.1 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like DUF166 PF02593.14 PIK35490.1 - 0.035 13.6 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function Herpes_U44 PF04533.13 PIK35491.1 - 0.083 12.5 0.0 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Herpes virus U44 protein RT_RNaseH_2 PF17919.1 PIK35492.1 - 3e-32 110.6 0.0 5.4e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35492.1 - 3.9e-28 97.8 0.0 6.7e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK35492.1 - 0.016 15.3 0.0 0.039 14.0 0.0 1.7 1 0 0 1 1 1 0 Integrase zinc binding domain NACHT PF05729.12 PIK35494.1 - 8.8e-08 32.2 0.0 2e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK35494.1 - 0.018 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK35496.1 - 4.7e-09 36.4 0.0 1.2e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 NACHT domain DUF4723 PF15851.5 PIK35496.1 - 0.012 15.7 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) AAA_25 PF13481.6 PIK35496.1 - 0.014 15.0 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF885 PF05960.11 PIK35496.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF885) WD40 PF00400.32 PIK35497.1 - 1.8e-06 28.6 1.1 2.1e-05 25.2 0.1 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK35497.1 - 0.0001 22.5 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK35497.1 - 0.077 11.6 0.0 0.078 11.6 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup120/160 WD40 PF00400.32 PIK35498.1 - 9.1e-07 29.5 0.2 0.0064 17.3 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ABC_tran PF00005.27 PIK35499.1 - 4.4e-44 150.3 0.3 1.1e-29 103.8 0.0 3.7 2 1 1 3 3 3 3 ABC transporter ABC_membrane PF00664.23 PIK35499.1 - 1.9e-34 119.6 16.5 2.7e-34 119.1 16.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK35499.1 - 5e-07 29.4 5.8 0.015 14.8 0.1 4.3 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 PIK35499.1 - 0.00024 20.8 0.2 0.039 13.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 PIK35499.1 - 0.0026 17.8 0.7 0.0082 16.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK35499.1 - 0.0028 18.0 0.4 0.016 15.6 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 PIK35499.1 - 0.0032 17.3 4.1 4.2 7.1 0.1 4.3 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 PIK35499.1 - 0.035 14.4 1.7 2.3 8.5 0.1 3.5 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 PIK35499.1 - 0.048 12.8 0.0 0.099 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF87 PF01935.17 PIK35499.1 - 0.092 12.8 1.6 0.093 12.8 0.0 1.8 2 0 0 2 2 1 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 PIK35499.1 - 0.14 12.0 1.5 0.93 9.4 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase AAA_23 PF13476.6 PIK35499.1 - 1.3 9.5 13.9 0.63 10.5 0.1 3.6 4 0 0 4 4 4 0 AAA domain ABC_membrane PF00664.23 PIK35500.1 - 1.8e-24 86.9 8.7 2.3e-24 86.5 8.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ASFV_p27 PF06556.11 PIK35500.1 - 0.093 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus Drf_FH3 PF06367.16 PIK35500.1 - 0.14 11.7 0.1 6.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Diaphanous FH3 Domain Adap_comp_sub PF00928.21 PIK35501.1 - 6e-72 242.2 0.0 7.3e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK35501.1 - 0.013 15.4 0.9 3 7.8 0.1 2.4 1 1 1 2 2 2 0 Clathrin adaptor complex small chain Fibrinogen_C PF00147.18 PIK35502.1 - 1.1e-31 110.4 6.2 1.3e-16 61.1 0.7 2.0 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Nsp3_PL2pro PF12124.8 PIK35502.1 - 0.054 13.3 0.1 0.087 12.6 0.1 1.3 1 0 0 1 1 1 0 Coronavirus polyprotein cleavage domain CFC PF09443.10 PIK35502.1 - 0.76 9.7 6.6 0.44 10.4 4.1 1.8 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) FPN1 PF06963.12 PIK35504.1 - 1e-68 231.9 7.5 5.6e-39 133.9 5.8 2.1 2 0 0 2 2 2 2 Ferroportin1 (FPN1) zf-UBR PF02207.20 PIK35505.1 - 6.5e-19 67.9 8.5 1e-18 67.2 8.5 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 PIK35505.1 - 6.2 7.1 6.8 4.7 7.4 4.8 1.8 2 1 0 2 2 2 0 B-box zinc finger zf-RING_5 PF14634.6 PIK35506.1 - 0.00039 20.3 2.0 0.00039 20.3 2.0 3.2 3 0 0 3 3 3 1 zinc-RING finger domain Glycos_transf_2 PF00535.26 PIK35507.1 - 1.7e-32 112.6 0.0 2.6e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK35507.1 - 6.4e-31 107.3 0.2 1.3e-30 106.3 0.2 1.5 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 PIK35507.1 - 1.7e-09 38.2 0.0 9.7e-05 23.0 0.0 3.6 2 1 2 4 4 4 3 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 PIK35507.1 - 9.4e-06 25.3 0.0 2.4e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 PIK35507.1 - 0.00016 21.3 0.0 0.00034 20.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 PIK35507.1 - 0.0034 17.3 0.0 0.0064 16.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RVT_1 PF00078.27 PIK35511.1 - 1.5e-30 106.4 1.1 1.7e-30 106.2 1.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Helicase_PWI PF18149.1 PIK35511.1 - 0.00012 22.2 1.4 0.2 11.9 0.0 2.8 3 1 1 4 4 4 2 N-terminal helicase PWI domain DUF2303 PF10065.9 PIK35511.1 - 0.14 11.2 0.4 0.23 10.6 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2303) Zip PF02535.22 PIK35512.1 - 4.4e-44 151.1 13.1 1.4e-43 149.4 13.1 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter Pkinase_Tyr PF07714.17 PIK35513.1 - 2.2e-48 164.8 0.0 2.7e-48 164.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35513.1 - 1.7e-14 53.9 0.0 2.1e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35514.1 - 9e-50 169.4 0.0 1.2e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35514.1 - 8.5e-17 61.4 0.0 1.1e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain NifZ PF04319.13 PIK35514.1 - 0.05 13.4 0.1 0.15 11.9 0.1 1.7 2 0 0 2 2 2 0 NifZ domain DAP_epimerase PF01678.19 PIK35514.1 - 0.091 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelate epimerase DUF2944 PF11161.8 PIK35514.1 - 0.19 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) SKG6 PF08693.10 PIK35515.1 - 7.9e-05 22.0 0.0 0.0001 21.6 0.0 1.1 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Gram_pos_anchor PF00746.21 PIK35515.1 - 0.038 13.9 1.3 0.12 12.4 0.3 2.1 1 1 1 2 2 2 0 LPXTG cell wall anchor motif NCU-G1 PF15065.6 PIK35515.1 - 0.18 10.8 0.1 0.19 10.7 0.1 1.0 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 ABC_tran PF00005.27 PIK35517.1 - 1.6e-50 171.2 0.1 1.3e-29 103.5 0.1 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 PIK35517.1 - 1e-45 156.6 34.1 1.9e-29 103.2 14.7 2.4 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 PIK35517.1 - 9.3e-12 44.8 9.9 0.00099 18.6 1.6 4.3 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 PIK35517.1 - 0.00091 19.3 2.3 1.2 9.2 0.4 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK35517.1 - 0.0033 17.8 0.3 2 8.8 0.1 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 PIK35517.1 - 0.029 14.2 6.3 2.7 7.7 0.1 3.7 2 2 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 PIK35517.1 - 0.032 14.8 0.1 11 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 PIK35517.1 - 0.038 14.5 4.7 0.59 10.6 0.1 2.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 PIK35517.1 - 0.04 13.8 3.5 0.7 9.8 0.2 2.6 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 PIK35517.1 - 0.043 13.9 3.6 0.93 9.5 0.4 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_22 PF13401.6 PIK35517.1 - 0.044 14.1 1.6 12 6.2 0.1 3.2 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 PIK35517.1 - 0.044 13.4 1.2 0.18 11.4 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 PIK35517.1 - 0.1 12.4 7.6 1.6 8.6 0.1 2.9 3 0 0 3 3 3 0 P-loop containing region of AAA domain NB-ARC PF00931.22 PIK35517.1 - 0.1 11.7 1.4 3.5 6.7 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain Dynamin_N PF00350.23 PIK35517.1 - 0.51 10.4 7.2 0.17 11.9 0.4 2.6 2 0 0 2 2 2 0 Dynamin family TNFR_c6 PF00020.18 PIK35518.1 - 2.2e-05 24.8 10.9 2.2e-05 24.8 10.9 2.0 2 0 0 2 2 2 1 TNFR/NGFR cysteine-rich region TMEM154 PF15102.6 PIK35518.1 - 0.00027 20.8 0.3 0.00042 20.2 0.3 1.4 1 0 0 1 1 1 1 TMEM154 protein family Calcyon PF06387.11 PIK35518.1 - 0.0092 16.0 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) DUF3377 PF11857.8 PIK35518.1 - 0.038 13.9 0.5 0.067 13.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) COMM_domain PF07258.14 PIK35519.1 - 4.8e-24 84.3 1.4 5.3e-24 84.1 0.2 1.7 2 0 0 2 2 2 1 COMM domain EST1_DNA_bind PF10373.9 PIK35520.1 - 0.17 11.3 5.2 3.9 6.9 0.5 2.3 2 0 0 2 2 2 0 Est1 DNA/RNA binding domain Collagen PF01391.18 PIK35521.1 - 2.5e-17 62.4 56.8 3.3e-07 30.0 20.4 3.2 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) C1q PF00386.21 PIK35521.1 - 3.6e-08 33.7 0.0 4.9e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain ELO PF01151.18 PIK35522.1 - 1.2e-60 205.1 32.6 1.5e-60 204.9 32.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 PIK35523.1 - 9.7e-35 120.3 8.4 1.1e-34 120.0 8.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Nucleos_tra2_C PF07662.13 PIK35523.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter C-terminus AMP-binding PF00501.28 PIK35524.1 - 2.5e-28 98.8 0.0 3.8e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK35524.1 - 0.00013 22.9 0.0 0.00026 21.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Tetraspanin PF00335.20 PIK35525.1 - 4.9e-40 137.7 15.9 5.7e-40 137.4 15.9 1.1 1 0 0 1 1 1 1 Tetraspanin family Corona_M PF01635.18 PIK35525.1 - 0.12 11.7 1.9 0.23 10.7 1.9 1.5 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein Tubulin_3 PF14881.6 PIK35526.1 - 1.3e-15 57.5 0.7 2e-15 56.9 0.7 1.2 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 PIK35526.1 - 4.7e-10 39.8 0.0 9.7e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 PIK35526.1 - 0.14 12.3 0.0 3.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain Aminotran_3 PF00202.21 PIK35526.1 - 0.25 9.9 0.0 0.45 9.1 0.0 1.4 2 0 0 2 2 2 0 Aminotransferase class-III PTPS PF01242.19 PIK35527.1 - 2.9e-32 111.2 0.1 3.3e-32 111.0 0.1 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase mTERF PF02536.14 PIK35528.1 - 1.9e-17 63.2 0.0 2.6e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 mTERF Forkhead PF00250.18 PIK35529.1 - 8.1e-36 122.2 0.1 9.7e-36 121.9 0.1 1.0 1 0 0 1 1 1 1 Forkhead domain Ras PF00071.22 PIK35530.1 - 1.1e-46 158.4 0.0 1.3e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK35530.1 - 3.8e-33 114.3 0.0 4.8e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK35530.1 - 5.7e-10 38.9 0.0 8.3e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK35530.1 - 0.001 19.1 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK35530.1 - 0.0083 15.7 0.0 0.0094 15.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK35530.1 - 0.061 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 PIK35530.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 PIK35530.1 - 0.16 11.3 0.2 0.37 10.1 0.2 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region TMEM214 PF10151.9 PIK35531.1 - 2.8e-37 128.6 0.7 3.5e-37 128.2 0.7 1.1 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator IL32 PF15225.6 PIK35531.1 - 0.0088 16.4 0.6 0.021 15.2 0.6 1.6 1 0 0 1 1 1 1 Interleukin 32 Ets PF00178.22 PIK35532.1 - 5.2e-30 103.8 1.1 8.6e-30 103.0 1.1 1.4 1 0 0 1 1 1 1 Ets-domain HSF_DNA-bind PF00447.17 PIK35532.1 - 0.088 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 HSF-type DNA-binding Ank_2 PF12796.7 PIK35534.1 - 1.4e-45 153.7 3.2 3.3e-16 59.6 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK35534.1 - 1.5e-26 92.1 0.9 1.3e-08 34.9 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK35534.1 - 9.2e-26 87.1 0.5 0.00047 20.4 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 PIK35534.1 - 1.1e-25 89.7 0.1 5.6e-07 30.0 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK35534.1 - 9.2e-25 86.0 0.7 0.00013 22.2 0.0 6.4 6 0 0 6 6 6 6 Ankyrin repeat DEAD PF00270.29 PIK35535.1 - 2.3e-43 148.0 0.0 7.2e-43 146.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK35535.1 - 2.1e-24 86.0 0.0 6.2e-23 81.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 PIK35535.1 - 7.3e-20 70.6 2.4 6.5e-11 41.9 0.4 2.9 2 0 0 2 2 2 2 KH domain MOEP19 PF16005.5 PIK35535.1 - 1.9e-06 27.8 0.0 8.4e-05 22.5 0.0 2.5 2 0 0 2 2 2 1 KH-like RNA-binding domain CMS1 PF14617.6 PIK35535.1 - 0.0015 17.9 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 PIK35535.1 - 0.0028 17.7 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RPAP1_N PF08621.10 PIK35535.1 - 0.0059 16.3 0.2 0.031 14.0 0.1 2.2 2 0 0 2 2 2 1 RPAP1-like, N-terminal CsgF PF10614.9 PIK35535.1 - 0.12 12.6 0.2 25 5.1 0.0 2.9 3 0 0 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein Ras PF00071.22 PIK35536.1 - 1.3e-23 83.4 0.0 1.4e-23 83.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK35536.1 - 1.3e-08 35.0 0.0 1.9e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK35536.1 - 1.5e-06 27.8 0.0 2e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK35536.1 - 0.00038 20.5 0.0 0.00053 20.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK35536.1 - 0.00074 19.1 0.3 0.037 13.6 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 PIK35536.1 - 0.061 12.9 0.1 6.2 6.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 PIK35536.1 - 0.064 13.2 0.1 0.99 9.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase Fibrinogen_C PF00147.18 PIK35537.1 - 2e-91 305.7 22.3 2.4e-51 174.7 16.0 2.6 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK35537.1 - 0.00013 22.1 5.5 0.00013 22.1 5.5 3.4 3 0 0 3 3 3 1 EGF domain EGF PF00008.27 PIK35537.1 - 3.8 7.9 18.0 0.071 13.4 4.7 4.1 2 2 1 3 3 3 0 EGF-like domain Peptidase_M2 PF01401.18 PIK35538.1 - 1.8e-190 634.4 0.5 2e-190 634.2 0.5 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Sugar_tr PF00083.24 PIK35539.1 - 2.6e-92 310.0 20.7 3.3e-92 309.7 20.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK35539.1 - 9e-31 107.1 34.3 4.7e-29 101.4 31.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK35539.1 - 0.033 13.1 13.7 0.041 12.7 2.9 2.7 1 1 2 3 3 3 0 MFS_1 like family RVT_1 PF00078.27 PIK35540.1 - 1.4e-29 103.2 0.0 2.1e-29 102.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E2F_TDP PF02319.20 PIK35541.1 - 1.4e-24 85.9 0.1 2.1e-24 85.3 0.1 1.3 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 PIK35541.1 - 2.1e-14 53.6 0.0 3.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain dCMP_cyt_deam_1 PF00383.23 PIK35542.1 - 2.2e-21 75.6 0.1 3.1e-21 75.1 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 PIK35542.1 - 4.8e-19 68.5 0.0 6.2e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 PIK35542.1 - 0.0018 18.4 1.3 0.02 15.0 1.3 2.1 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 PIK35542.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 PIK35542.1 - 0.0085 16.2 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 PIK35542.1 - 0.016 15.3 0.0 0.021 15.0 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 PIK35542.1 - 0.024 14.8 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 APOBEC3 NAD2 PF18782.1 PIK35542.1 - 0.035 14.2 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Aminoglyc_resit PF10706.9 PIK35542.1 - 0.041 13.6 0.1 0.27 10.9 0.1 1.9 1 1 1 2 2 2 0 Aminoglycoside-2''-adenylyltransferase APOBEC1 PF18769.1 PIK35542.1 - 0.078 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 APOBEC1 Amidase PF01425.21 PIK35543.1 - 3.8e-45 154.7 2.8 7.9e-26 91.0 2.5 2.1 2 0 0 2 2 2 2 Amidase HMG_box PF00505.19 PIK35545.1 - 0.015 15.7 5.0 0.015 15.7 5.0 3.9 4 1 1 5 5 5 0 HMG (high mobility group) box DUF2489 PF10675.9 PIK35545.1 - 0.016 15.1 0.2 0.024 14.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) HMG_box_2 PF09011.10 PIK35545.1 - 0.29 11.7 8.2 5.7 7.6 3.3 2.8 1 1 1 2 2 2 0 HMG-box domain rve PF00665.26 PIK35546.1 - 1.5e-16 60.7 0.0 3.9e-16 59.3 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain DDE_3 PF13358.6 PIK35546.1 - 0.0031 17.3 0.0 0.0055 16.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.6 PIK35546.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Retrotran_gag_2 PF14223.6 PIK35547.1 - 0.00025 20.7 2.9 0.00042 20.0 2.9 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Asp1 PF16993.5 PIK35547.1 - 0.039 13.2 0.6 0.048 12.9 0.6 1.1 1 0 0 1 1 1 0 Accessory Sec system protein Asp1 ASL_C PF08328.11 PIK35547.1 - 0.041 14.0 0.1 0.082 13.0 0.1 1.6 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DUF2524 PF10732.9 PIK35547.1 - 0.41 11.0 3.3 1.2 9.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Complex1_49kDa PF00346.19 PIK35549.1 - 1.5e-92 309.5 0.0 2e-92 309.2 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 PIK35549.1 - 0.00032 19.7 0.1 0.0005 19.1 0.1 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase RasGEF PF00617.19 PIK35550.1 - 1.2e-07 32.2 0.1 6e-07 29.8 0.1 2.1 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 PIK35550.1 - 1.5e-07 31.6 0.1 1.5e-07 31.6 0.1 4.0 5 0 0 5 5 5 1 RasGEF N-terminal motif TniB PF05621.11 PIK35550.1 - 0.0077 15.7 0.1 0.016 14.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial TniB protein HR1 PF02185.16 PIK35550.1 - 1.1 9.4 6.7 0.7 10.0 3.4 2.5 2 0 0 2 2 2 0 Hr1 repeat zf-tcix PF14952.6 PIK35551.1 - 9.6e-17 60.3 7.1 9.6e-17 60.3 7.1 2.1 2 0 0 2 2 2 1 Putative treble-clef, zinc-finger, Zn-binding Mu-like_Com PF10122.9 PIK35551.1 - 0.032 13.7 0.7 0.069 12.6 0.7 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com zf-ribbon_3 PF13248.6 PIK35551.1 - 0.086 12.3 0.9 1.6 8.2 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain TAF4 PF05236.14 PIK35551.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ank_2 PF12796.7 PIK35552.1 - 1.4e-22 80.1 0.2 3.1e-08 34.1 0.0 4.1 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK35552.1 - 4.9e-17 62.1 0.1 3.8e-07 30.5 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK35552.1 - 2.6e-16 59.4 0.4 2.1e-08 34.2 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK35552.1 - 1.7e-12 46.3 3.5 0.0009 19.5 0.0 6.0 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 PIK35552.1 - 2.7e-11 43.4 0.4 0.0013 19.1 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Sec15 PF04091.12 PIK35554.1 - 2.5e-68 230.8 0.9 3.1e-68 230.5 0.9 1.0 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Fez1 PF06818.15 PIK35557.1 - 0.00074 20.0 13.1 0.00093 19.7 13.1 1.1 1 0 0 1 1 1 1 Fez1 HMMR_N PF15905.5 PIK35557.1 - 0.001 18.6 17.5 0.001 18.6 17.5 2.0 1 1 1 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 PIK35557.1 - 0.0016 17.4 17.0 0.0019 17.1 17.0 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein Lebercilin PF15619.6 PIK35557.1 - 0.0026 17.5 23.7 0.0051 16.5 23.7 1.4 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease BBP1_C PF15272.6 PIK35557.1 - 0.01 15.7 19.5 0.016 15.1 19.5 1.3 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF4618 PF15397.6 PIK35557.1 - 0.011 15.2 13.5 0.014 14.8 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DUF1664 PF07889.12 PIK35557.1 - 0.021 14.8 9.5 0.028 14.4 4.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMCO5 PF14992.6 PIK35557.1 - 0.023 14.3 15.9 0.029 13.9 15.9 1.1 1 0 0 1 1 1 0 TMCO5 family T3SSipB PF16535.5 PIK35557.1 - 0.036 14.6 9.7 0.12 12.8 6.9 2.1 1 1 1 2 2 2 0 Type III cell invasion protein SipB Tropomyosin_1 PF12718.7 PIK35557.1 - 0.04 14.1 20.5 0.28 11.3 20.5 1.9 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.8 PIK35557.1 - 0.071 13.2 19.1 0.51 10.4 19.3 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding TRAF_BIRC3_bd PF16673.5 PIK35557.1 - 0.073 12.9 8.9 0.057 13.2 3.8 2.7 1 1 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Fib_alpha PF08702.10 PIK35557.1 - 0.085 13.0 13.9 0.12 12.6 13.9 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 PIK35557.1 - 0.11 11.1 11.3 0.13 10.8 11.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 PIK35557.1 - 0.11 12.0 9.2 0.13 11.8 9.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PKcGMP_CC PF16808.5 PIK35557.1 - 0.2 11.6 9.8 2 8.3 0.0 3.7 2 2 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 PIK35557.1 - 0.21 11.9 16.4 0.22 11.8 1.9 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) YscJ_FliF PF01514.17 PIK35557.1 - 0.24 11.1 4.9 0.31 10.7 4.9 1.3 1 1 0 1 1 1 0 Secretory protein of YscJ/FliF family ATG16 PF08614.11 PIK35557.1 - 0.25 11.5 17.3 0.33 11.2 17.3 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Goodbye PF17109.5 PIK35557.1 - 0.25 11.8 10.1 0.55 10.7 1.5 2.2 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain DUF2203 PF09969.9 PIK35557.1 - 0.28 11.9 9.3 2.9 8.6 9.3 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF3810 PF12725.7 PIK35557.1 - 0.29 10.4 5.1 0.35 10.2 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) V_ATPase_I PF01496.19 PIK35557.1 - 0.3 9.0 10.8 0.34 8.8 10.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 PIK35557.1 - 0.31 11.6 19.3 0.45 11.1 19.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region XRN_M PF17846.1 PIK35557.1 - 0.34 9.8 8.2 0.39 9.6 8.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain CC2-LZ PF16516.5 PIK35557.1 - 0.39 11.1 15.8 2.2 8.7 9.7 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Csm1_N PF18504.1 PIK35557.1 - 0.49 10.8 21.7 3.4 8.1 6.0 3.8 1 1 3 4 4 4 0 Csm1 N-terminal domain Fmp27_WPPW PF10359.9 PIK35557.1 - 0.58 9.0 15.2 0.095 11.5 10.1 1.7 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF2730 PF10805.8 PIK35557.1 - 0.68 10.1 8.2 0.15 12.2 0.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) CREPT PF16566.5 PIK35557.1 - 0.84 9.8 13.8 0.61 10.3 8.2 2.0 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2663 PF10864.8 PIK35557.1 - 1.5 9.3 12.6 1.1 9.6 10.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) Atg14 PF10186.9 PIK35557.1 - 1.5 7.8 14.7 1.9 7.5 14.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ApoO PF09769.9 PIK35557.1 - 1.7 8.6 5.2 7.2 6.6 2.6 2.1 1 1 1 2 2 2 0 Apolipoprotein O Jnk-SapK_ap_N PF09744.9 PIK35557.1 - 2.1 8.6 20.7 3.4 7.9 20.7 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 YabA PF06156.13 PIK35557.1 - 2.1 9.0 11.7 1.3 9.7 2.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA YlqD PF11068.8 PIK35557.1 - 2.2 8.7 15.4 5.8 7.3 15.4 1.6 1 1 0 1 1 1 0 YlqD protein MRPL52 PF18699.1 PIK35557.1 - 3 8.1 15.3 2.3 8.5 13.6 1.7 1 1 0 1 1 1 0 Mitoribosomal protein mL52 HemX PF04375.14 PIK35557.1 - 4.4 6.5 13.8 8 5.6 13.8 1.5 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4404 PF14357.6 PIK35557.1 - 4.5 8.0 13.9 3.1 8.5 1.8 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) LPP PF04728.13 PIK35557.1 - 4.8 7.6 8.6 9.4 6.7 0.4 2.9 1 1 2 3 3 3 0 Lipoprotein leucine-zipper Presenilin PF01080.17 PIK35557.1 - 5.3 5.7 8.7 6 5.5 8.7 1.1 1 0 0 1 1 1 0 Presenilin SlyX PF04102.12 PIK35557.1 - 5.6 7.7 10.3 9.7 6.9 0.4 2.5 1 1 1 2 2 2 0 SlyX TMPIT PF07851.13 PIK35557.1 - 6.2 6.0 17.5 2.8 7.1 4.4 1.8 1 1 1 2 2 2 0 TMPIT-like protein DUF4446 PF14584.6 PIK35557.1 - 7.1 6.6 10.9 4.4 7.3 8.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF724 PF05266.14 PIK35557.1 - 9.4 6.0 18.2 26 4.6 18.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF2207 PF09972.9 PIK35557.1 - 9.5 4.9 10.1 12 4.5 10.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Golgin_A5 PF09787.9 PIK35558.1 - 0.00042 19.9 18.6 0.00042 19.9 18.6 1.7 2 0 0 2 2 2 1 Golgin subfamily A member 5 HAUS-augmin3 PF14932.6 PIK35558.1 - 0.00069 19.3 18.7 0.0011 18.6 18.7 1.3 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 PIK35558.1 - 0.00084 18.3 16.6 0.0015 17.5 16.6 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Fib_alpha PF08702.10 PIK35558.1 - 0.029 14.6 13.6 0.33 11.1 0.8 2.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family HALZ PF02183.18 PIK35558.1 - 0.029 14.6 0.3 0.029 14.6 0.3 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper Filament PF00038.21 PIK35558.1 - 0.12 11.9 21.1 0.022 14.3 15.7 2.3 1 1 0 2 2 2 0 Intermediate filament protein CheY-binding PF09078.11 PIK35558.1 - 0.42 10.8 7.3 2.2 8.5 0.0 4.0 2 2 2 4 4 4 0 CheY binding DUF4686 PF15742.5 PIK35558.1 - 0.48 9.5 29.8 0.65 9.1 27.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) COMMD1_N PF17221.3 PIK35558.1 - 0.62 10.4 10.4 0.16 12.3 1.7 2.4 1 1 1 2 2 2 0 COMMD1 N-terminal domain DUF4407 PF14362.6 PIK35558.1 - 0.8 9.0 12.9 2 7.7 12.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FUSC PF04632.12 PIK35558.1 - 1.6 7.2 3.2 4.2 5.8 1.2 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family GAS PF13851.6 PIK35558.1 - 1.7 8.0 26.0 0.68 9.3 22.4 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 PIK35558.1 - 2.2 8.6 0.0 2.2 8.6 0.0 3.3 2 1 1 3 3 3 0 Uncharacterized conserved protein Fez1 PF06818.15 PIK35558.1 - 2.8 8.3 22.9 41 4.5 22.6 2.3 1 1 0 1 1 1 0 Fez1 ENT PF03735.14 PIK35558.1 - 3.1 7.9 9.3 0.56 10.3 2.2 3.0 3 0 0 3 3 3 0 ENT domain V_ATPase_I PF01496.19 PIK35558.1 - 3.9 5.3 11.9 4.9 4.9 11.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 PIK35558.1 - 5.8 5.9 22.7 3.1 6.8 20.4 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PCNP PF15473.6 PIK35559.1 - 8.1e-32 111.1 6.4 1.1e-31 110.6 6.4 1.2 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family Phos_pyr_kin PF08543.12 PIK35560.1 - 1e-17 64.3 0.0 1.4e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 PIK35560.1 - 3.3e-11 43.1 0.0 4.8e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TMEM154 PF15102.6 PIK35561.1 - 0.0019 18.1 1.3 0.0031 17.4 1.2 1.5 1 1 0 1 1 1 1 TMEM154 protein family DUF1735 PF08522.10 PIK35561.1 - 0.097 13.3 1.3 1.7 9.3 1.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1735) AC_N PF16214.5 PIK35561.1 - 0.13 11.4 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Nha1_C PF08619.10 PIK35561.1 - 0.18 11.0 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Herpes_BLLF1 PF05109.13 PIK35561.1 - 1.8 6.5 16.9 2.3 6.1 16.9 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) DUF1180 PF06679.12 PIK35562.1 - 0.0039 17.6 0.4 0.0039 17.6 0.4 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1180) Trypan_PARP PF05887.11 PIK35562.1 - 0.0063 16.5 13.4 0.0063 16.5 13.4 3.1 2 1 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF2868 PF11067.8 PIK35562.1 - 0.078 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Stevor PF17410.2 PIK35562.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Tubulin PF00091.25 PIK35563.1 - 4e-66 223.0 0.0 5.8e-66 222.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK35563.1 - 3.8e-51 172.5 0.0 5.9e-51 171.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK35563.1 - 0.0015 18.3 0.0 0.0031 17.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Rep_3 PF01051.21 PIK35565.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Initiator Replication protein UCH PF00443.29 PIK35567.1 - 4.7e-30 104.9 0.0 5.4e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK35567.1 - 5.1e-07 29.6 1.4 0.0046 16.6 0.5 2.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RsbRD_N PF14361.6 PIK35567.1 - 0.0041 17.8 0.0 0.018 15.7 0.0 2.0 2 0 0 2 2 2 1 RsbT co-antagonist protein rsbRD N-terminal domain Peptidase_C98 PF15499.6 PIK35567.1 - 0.031 13.8 0.1 0.92 8.9 0.0 2.5 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Cation_ATPase PF13246.6 PIK35568.1 - 2.1e-07 30.9 0.0 3.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 PIK35568.1 - 0.002 18.4 0.0 0.0025 18.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase zf-C2H2 PF00096.26 PIK35570.1 - 4.2e-10 39.5 18.7 0.0006 20.1 0.9 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35570.1 - 1.4e-08 34.9 22.6 0.0053 17.5 0.1 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK35570.1 - 1.2e-05 25.6 20.6 0.0052 17.1 0.6 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-Di19 PF05605.12 PIK35570.1 - 0.00092 19.5 5.5 0.00092 19.5 5.5 3.4 3 1 1 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK35570.1 - 0.0092 16.0 23.1 0.026 14.5 1.4 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK35570.1 - 0.12 13.0 11.5 5.4 7.7 5.5 3.9 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK35570.1 - 0.13 12.6 9.1 0.84 10.0 2.7 3.0 2 1 1 3 3 3 0 C2H2-type zinc ribbon DUF678 PF05077.12 PIK35570.1 - 0.78 9.9 8.8 6.8 6.9 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF678) zf-C2H2_9 PF16293.5 PIK35570.1 - 0.79 9.6 10.4 0.8 9.6 0.2 3.8 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 PIK35570.1 - 0.88 9.9 16.5 27 5.2 1.1 4.3 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF948 PF06103.11 PIK35571.1 - 0.2 11.9 0.0 0.2 11.9 0.0 3.8 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Aminotran_1_2 PF00155.21 PIK35574.1 - 2.7e-19 69.6 0.0 3.5e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Laminin_N PF00055.17 PIK35575.1 - 3.1e-48 164.4 0.0 3.1e-48 164.4 0.0 2.4 2 1 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 PIK35575.1 - 2.5e-20 72.3 55.9 1.7e-08 34.5 13.0 3.4 3 0 0 3 3 3 3 Laminin EGF domain EGF_2 PF07974.13 PIK35575.1 - 0.0091 16.4 3.2 0.0091 16.4 3.2 6.6 5 3 1 6 6 6 1 EGF-like domain DUF4470 PF14737.6 PIK35577.1 - 2.8e-16 59.5 0.0 4.3e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 PIK35577.1 - 2.5e-08 33.9 33.6 1.1e-07 31.8 14.3 2.9 3 0 0 3 3 3 2 MYND finger zf-C6H2 PF15801.5 PIK35577.1 - 0.45 10.8 23.6 0.25 11.7 10.9 2.7 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding DUF4470 PF14737.6 PIK35578.1 - 3.4e-18 65.6 0.1 5.3e-18 65.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Porin_OmpG_1_2 PF16946.5 PIK35578.1 - 0.024 13.9 0.5 0.034 13.4 0.1 1.5 2 0 0 2 2 2 0 OMPG-porin 1 family DUF1041 PF06292.17 PIK35580.1 - 1.4e-33 115.4 1.4 1.4e-33 115.4 1.4 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) PH PF00169.29 PIK35580.1 - 1.4e-09 38.3 0.1 3.1e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 PH domain NUDIX PF00293.28 PIK35580.1 - 0.041 13.9 0.8 0.11 12.6 0.8 1.6 1 0 0 1 1 1 0 NUDIX domain DapB_N PF01113.20 PIK35580.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 PIK35581.1 - 1.1e-29 103.3 0.3 6e-18 65.0 0.0 2.8 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK35581.1 - 5.9e-20 71.8 0.0 8.7e-12 45.1 0.0 2.9 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK35581.1 - 9.3e-08 32.2 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 PIK35581.1 - 0.012 15.5 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 PIK35581.1 - 0.021 15.1 0.1 0.033 14.4 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain LDcluster4 PF18306.1 PIK35581.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster4 family TBP PF00352.21 PIK35581.1 - 0.031 14.2 1.3 6.5 6.8 0.1 2.4 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) F420_oxidored PF03807.17 PIK35581.1 - 0.054 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TetR_C_23 PF17931.1 PIK35581.1 - 0.081 13.0 1.2 0.51 10.5 0.0 2.4 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF1515 PF07439.11 PIK35581.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Adaptin_N PF01602.20 PIK35582.1 - 1.4e-104 350.6 4.4 1.8e-104 350.2 4.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 PIK35582.1 - 2.7e-10 40.5 3.2 5.9e-07 29.7 0.1 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 PIK35582.1 - 4.7e-10 38.9 1.2 0.14 12.4 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 PIK35582.1 - 1.4e-09 38.2 0.4 0.27 11.7 0.0 6.2 4 3 3 7 7 7 3 HEAT repeats HEAT_EZ PF13513.6 PIK35582.1 - 1.4e-06 28.7 1.4 1.2 9.7 0.0 5.2 5 0 0 5 5 5 2 HEAT-like repeat MMS19_N PF14500.6 PIK35582.1 - 0.0015 18.1 0.1 0.0092 15.6 0.0 2.3 2 1 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 PIK35582.1 - 0.0024 17.8 0.1 11 6.2 0.0 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 PIK35582.1 - 0.15 12.3 0.0 0.54 10.5 0.0 2.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 Condensin2nSMC PF12422.8 PIK35582.1 - 0.19 11.9 0.9 10 6.3 0.1 3.4 4 0 0 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit Peptidase_A17 PF05380.13 PIK35584.1 - 1.6e-27 96.5 0.2 2.4e-27 95.9 0.2 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase DNA_pol_viral_C PF00336.18 PIK35584.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RNase_H PF00075.24 PIK35584.1 - 0.015 15.5 0.4 0.032 14.4 0.2 1.7 1 1 0 1 1 1 0 RNase H Destabilase PF05497.12 PIK35584.1 - 0.023 15.1 0.3 0.06 13.7 0.3 1.6 1 0 0 1 1 1 0 Destabilase DUF3475 PF11961.8 PIK35585.1 - 0.14 12.3 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3475) RVT_1 PF00078.27 PIK35586.1 - 1.2e-15 57.6 0.0 1.8e-15 57.1 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK35587.1 - 7e-06 26.5 0.0 1.1e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK35587.1 - 0.00055 20.2 0.0 0.00096 19.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK35587.1 - 0.0018 18.9 0.0 0.0026 18.4 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease DUF4371 PF14291.6 PIK35588.1 - 7.8e-11 42.1 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK35588.1 - 0.00067 19.6 0.1 0.0016 18.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) ig PF00047.25 PIK35589.1 - 4.7e-11 42.7 0.6 1.1e-07 32.0 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK35589.1 - 2e-10 41.1 4.1 1.5e-05 25.5 0.0 3.8 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK35589.1 - 2.9e-07 30.6 1.5 1.1e-05 25.5 0.0 2.7 3 1 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK35589.1 - 6.4e-07 29.4 0.1 0.00014 21.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK35589.1 - 9e-07 29.1 6.8 0.039 14.3 0.1 4.3 3 2 1 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK35589.1 - 0.002 18.2 0.1 0.0037 17.3 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Marek_A PF02124.15 PIK35589.1 - 0.039 13.8 0.2 0.092 12.6 0.0 1.6 2 0 0 2 2 2 0 Marek's disease glycoprotein A Izumo-Ig PF16706.5 PIK35589.1 - 0.043 13.9 0.0 0.098 12.7 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Sm_multidrug_ex PF06695.11 PIK35589.1 - 0.11 13.2 0.1 0.18 12.5 0.1 1.3 1 0 0 1 1 1 0 Putative small multi-drug export protein Ig_6 PF18452.1 PIK35589.1 - 0.13 11.9 0.5 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain TK PF00265.18 PIK35590.1 - 3e-22 79.3 0.4 4e-22 78.9 0.4 1.2 1 0 0 1 1 1 1 Thymidine kinase I-set PF07679.16 PIK35591.1 - 0.00064 19.7 0.2 0.32 11.1 0.0 2.6 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK35591.1 - 0.0048 17.1 0.6 2.4 8.4 0.0 2.6 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK35591.1 - 0.0052 16.8 0.6 0.011 15.8 0.6 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK35591.1 - 0.025 15.2 0.7 4.3 8.0 0.0 3.0 2 1 0 2 2 2 0 Immunoglobulin domain DUP PF00674.18 PIK35591.1 - 0.027 14.6 0.1 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 DUP family Ig_2 PF13895.6 PIK35591.1 - 0.032 14.6 0.7 8.3 6.8 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK35591.1 - 0.034 14.3 0.7 0.097 12.8 0.1 2.1 3 0 0 3 3 3 0 Immunoglobulin V-set domain RVT_1 PF00078.27 PIK35594.1 - 4.6e-21 75.4 0.8 6.7e-21 74.8 0.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SAP PF02037.27 PIK35594.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 SAP domain DUF2555 PF10742.9 PIK35594.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) Glyco_hydro_31 PF01055.26 PIK35595.1 - 2.3e-65 221.5 1.8 3.2e-65 221.0 1.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Pkinase_Tyr PF07714.17 PIK35596.1 - 7e-10 38.6 0.2 3.6e-09 36.3 0.2 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase THAP PF05485.12 PIK35597.1 - 1.8e-15 57.6 0.0 1.8e-15 57.6 0.0 1.9 3 0 0 3 3 3 1 THAP domain zf-trcl PF13451.6 PIK35597.1 - 1.3 9.0 3.6 0.91 9.5 0.3 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain Peptidase_S39 PF02122.15 PIK35598.1 - 0.065 12.7 0.1 0.091 12.3 0.1 1.1 1 0 0 1 1 1 0 Peptidase S39 Rad21_Rec8_N PF04825.13 PIK35599.1 - 6.4e-39 132.5 0.0 1.3e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein PRCC PF10253.9 PIK35599.1 - 2.8 8.7 6.5 7.7 7.2 0.8 2.5 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting TFIIS_M PF07500.14 PIK35600.1 - 1.2e-29 103.0 2.7 1.2e-29 103.0 2.7 2.1 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 PIK35600.1 - 5.4e-19 68.6 0.0 1.1e-18 67.6 0.0 1.4 1 0 0 1 1 1 1 SPOC domain PHD PF00628.29 PIK35600.1 - 1e-11 44.5 14.7 2.8e-11 43.1 14.7 1.8 1 0 0 1 1 1 1 PHD-finger BRK PF07533.16 PIK35600.1 - 6e-11 41.8 0.3 1.3e-10 40.7 0.3 1.6 1 0 0 1 1 1 1 BRK domain PHD_4 PF16866.5 PIK35600.1 - 0.033 14.3 11.5 0.095 12.8 11.5 1.8 1 0 0 1 1 1 0 PHD-finger Mu-like_Pro PF10123.9 PIK35600.1 - 2.2 7.8 12.5 0.08 12.5 3.5 2.5 2 1 0 2 2 2 0 Mu-like prophage I protein zf-4CXXC_R1 PF10497.9 PIK35600.1 - 3.1 8.1 13.2 0.84 9.9 8.3 2.3 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_2 PF13639.6 PIK35600.1 - 3.8 7.9 11.8 8.5 6.8 11.8 1.6 1 0 0 1 1 1 0 Ring finger domain DSPc PF00782.20 PIK35602.1 - 2.3e-07 30.7 0.0 2.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK35602.1 - 0.0003 20.4 0.0 0.00044 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK35602.1 - 0.044 13.9 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK35602.1 - 0.15 12.0 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PI31_Prot_N PF11566.8 PIK35603.1 - 3.8e-14 52.8 0.0 4.9e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 PIK35603.1 - 2.8e-06 28.4 13.8 6.2e-06 27.3 13.7 1.7 1 1 0 1 1 1 1 PI31 proteasome regulator EF-hand_7 PF13499.6 PIK35604.1 - 4.7e-20 71.8 13.0 1e-08 35.5 0.1 3.6 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.32 PIK35604.1 - 7.3e-19 65.8 0.3 0.0045 16.4 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 PIK35604.1 - 1.3e-14 52.9 1.6 0.0012 18.3 0.0 4.9 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK35604.1 - 1.4e-12 46.4 0.3 0.039 13.9 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 PIK35604.1 - 2e-09 37.1 0.9 0.02 14.7 0.1 3.6 3 1 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK35604.1 - 3.1e-08 33.9 5.7 0.0024 18.1 1.4 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF4073 PF13285.6 PIK35604.1 - 0.041 13.5 0.8 0.07 12.8 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) FAM124 PF15067.6 PIK35605.1 - 0.00047 19.9 0.0 0.00091 18.9 0.0 1.4 1 0 0 1 1 1 1 FAM124 family LRR_4 PF12799.7 PIK35606.1 - 1.2e-16 60.5 20.4 1.4e-06 28.6 1.8 7.2 4 3 3 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK35606.1 - 9.2e-09 35.1 0.0 1.8e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 PIK35606.1 - 9.8e-09 34.9 12.0 0.014 15.2 1.2 6.6 2 1 5 7 7 7 5 Leucine rich repeat F-box PF00646.33 PIK35606.1 - 1.7e-07 30.9 0.1 1.1e-06 28.3 0.0 2.5 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 PIK35606.1 - 4.1e-06 26.4 15.0 3.9 7.8 0.3 7.4 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 PIK35606.1 - 0.00016 21.7 24.5 0.46 11.2 0.2 9.6 11 0 0 11 11 11 2 Leucine Rich Repeat YL1 PF05764.13 PIK35606.1 - 0.0013 19.0 7.0 0.0019 18.4 7.0 1.2 1 0 0 1 1 1 1 YL1 nuclear protein AP3D1 PF06375.11 PIK35606.1 - 0.65 10.2 12.7 1.2 9.3 12.7 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DHHC PF01529.20 PIK35607.1 - 5.2e-29 101.1 15.6 5.2e-29 101.1 15.6 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2070 PF09843.9 PIK35607.1 - 5.7 5.1 6.1 3.8 5.7 4.2 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) bZIP_1 PF00170.21 PIK35608.1 - 1.6e-12 47.3 12.1 1.6e-12 47.3 12.1 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 PIK35608.1 - 1.3e-05 25.2 10.2 1.3e-05 25.2 10.2 3.0 2 1 1 3 3 3 1 Basic region leucine zipper ssDNA_DBD PF18333.1 PIK35608.1 - 0.072 13.2 0.6 0.26 11.4 0.6 1.9 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain LURAP PF14854.6 PIK35608.1 - 0.1 12.6 0.2 0.1 12.6 0.2 3.0 4 0 0 4 4 4 0 Leucine rich adaptor protein FlaC_arch PF05377.11 PIK35608.1 - 0.12 12.8 2.1 0.35 11.3 2.1 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CCDC-167 PF15188.6 PIK35608.1 - 4 7.9 12.1 2.5 8.5 1.4 2.8 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 bZIP_Maf PF03131.17 PIK35608.1 - 6.7 7.3 11.4 0.63 10.6 5.0 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor G-patch PF01585.23 PIK35609.1 - 1.7e-12 47.0 0.5 3.8e-12 45.9 0.5 1.6 1 0 0 1 1 1 1 G-patch domain SMN PF06003.12 PIK35609.1 - 1.1e-05 24.8 0.1 1.1e-05 24.8 0.1 2.2 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 PIK35609.1 - 0.0017 18.4 0.0 0.0047 16.9 0.0 1.8 1 0 0 1 1 1 1 Tudor domain DUF4537 PF15057.6 PIK35609.1 - 0.0075 16.3 0.0 0.044 13.8 0.0 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF4537) DUF1325 PF07039.11 PIK35609.1 - 0.012 15.7 0.0 0.046 13.8 0.0 2.0 1 0 0 1 1 1 0 SGF29 tudor-like domain zf-CCCH_4 PF18044.1 PIK35609.1 - 0.085 12.7 0.9 0.18 11.6 0.9 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger G-patch_2 PF12656.7 PIK35609.1 - 0.41 10.8 3.1 0.44 10.7 0.0 2.5 2 0 0 2 2 2 0 G-patch domain Longin PF13774.6 PIK35610.1 - 1.5e-25 89.1 0.9 3e-25 88.0 0.9 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 PIK35610.1 - 1.3e-16 60.1 0.7 2.1e-16 59.5 0.7 1.3 1 0 0 1 1 1 1 Synaptobrevin Sec20 PF03908.13 PIK35610.1 - 0.0034 17.3 0.1 0.0071 16.2 0.1 1.6 1 0 0 1 1 1 1 Sec20 Ligase_CoA PF00549.19 PIK35610.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 CoA-ligase NCKAP5 PF15246.6 PIK35610.1 - 0.15 11.6 0.8 0.2 11.3 0.8 1.2 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Sushi PF00084.20 PIK35611.1 - 5.5e-37 126.2 45.7 3.9e-07 30.6 1.2 10.0 9 0 0 9 9 9 9 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK35611.1 - 2e-10 41.1 1.8 0.00049 20.6 0.0 4.1 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK35611.1 - 1.2e-09 38.2 0.4 2.3e-05 24.5 0.0 3.5 4 0 0 4 4 4 2 Immunoglobulin domain F5_F8_type_C PF00754.25 PIK35611.1 - 5.3e-06 26.6 0.2 1.4e-05 25.2 0.2 1.8 1 0 0 1 1 1 1 F5/8 type C domain Ig_2 PF13895.6 PIK35611.1 - 0.00022 21.5 9.6 0.091 13.1 0.0 4.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_4 PF16680.5 PIK35611.1 - 0.00097 19.4 0.1 1.6 9.1 0.0 3.6 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK35611.1 - 0.0011 19.1 1.1 1.4 9.1 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.16 PIK35611.1 - 0.019 15.0 0.1 13 6.0 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin I-set domain Sad1_UNC PF07738.13 PIK35611.1 - 0.091 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal Sushi PF00084.20 PIK35612.1 - 8.7e-32 109.5 20.5 1.4e-11 44.8 0.4 5.3 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) HRM PF02793.22 PIK35612.1 - 0.0052 17.1 17.0 0.065 13.5 0.1 4.2 3 1 1 4 4 4 2 Hormone receptor domain cEGF PF12662.7 PIK35612.1 - 8 6.5 21.0 0.41 10.6 1.0 5.0 5 0 0 5 5 5 0 Complement Clr-like EGF-like Fam20C PF06702.12 PIK35613.1 - 6.7e-84 281.1 0.1 8.3e-84 280.8 0.1 1.1 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK35613.1 - 0.021 13.7 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 FAM198 protein AKNA PF12443.8 PIK35614.1 - 0.088 13.5 0.6 0.088 13.5 0.6 5.3 3 2 1 5 5 5 0 AT-hook-containing transcription factor EFP PF01132.20 PIK35614.1 - 0.19 11.8 2.2 0.19 11.8 0.4 2.0 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain PRANC PF09372.10 PIK35614.1 - 1.5 9.2 6.1 3.2 8.1 0.5 3.4 3 1 1 4 4 4 0 PRANC domain WD40 PF00400.32 PIK35615.1 - 2.2e-33 113.7 4.6 5.7e-09 36.5 0.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK35615.1 - 2.5e-09 37.3 0.1 0.0036 17.6 0.0 3.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK35615.1 - 0.00067 18.7 0.0 1.4 7.8 0.0 3.1 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK35615.1 - 0.027 13.8 0.0 1.7 7.9 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain P_C10 PF14974.6 PIK35616.1 - 1.4e-34 118.3 0.3 1.6e-34 118.1 0.3 1.0 1 0 0 1 1 1 1 Protein C10 Activator-TraM PF11657.8 PIK35616.1 - 0.011 15.6 0.6 0.023 14.5 0.1 1.7 2 0 0 2 2 2 0 Transcriptional activator TraM TFCD_C PF12612.8 PIK35616.1 - 0.066 13.0 0.0 0.073 12.9 0.0 1.2 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal AMP-binding PF00501.28 PIK35617.1 - 8.1e-71 238.8 0.0 1e-70 238.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C2 PF00168.30 PIK35620.1 - 1.6e-12 47.6 0.1 3.6e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 C2 domain TIMP PF00965.17 PIK35622.1 - 1.3e-08 34.9 0.1 3.8e-08 33.3 0.1 1.7 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK35622.1 - 0.067 13.0 0.1 7.1 6.5 0.0 2.2 2 0 0 2 2 2 0 UNC-6/NTR/C345C module Collagen PF01391.18 PIK35623.1 - 3.9e-14 52.1 127.0 2.6e-08 33.5 33.8 4.8 2 2 1 3 3 3 2 Collagen triple helix repeat (20 copies) rve PF00665.26 PIK35624.1 - 7e-19 68.2 0.0 1.3e-18 67.3 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK35624.1 - 3.1e-14 52.8 1.7 4.8e-14 52.2 1.7 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK35625.1 - 6.9e-14 51.7 0.0 1.3e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK35625.1 - 4.5e-13 49.2 0.2 1e-12 48.1 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2362 PF10154.9 PIK35625.1 - 0.023 13.6 0.0 0.027 13.5 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) RT_RNaseH PF17917.1 PIK35625.1 - 0.029 14.7 0.0 0.06 13.6 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DUF5498 PF17602.2 PIK35625.1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5498) SET PF00856.28 PIK35628.1 - 7.5e-09 36.2 0.0 4.9e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 SET domain DUF2052 PF09747.9 PIK35629.1 - 0.044 13.9 0.0 0.057 13.6 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) I-set PF07679.16 PIK35630.1 - 5.9e-58 192.9 0.0 1.6e-15 57.0 0.0 4.8 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35630.1 - 4.7e-53 177.7 3.4 1.3e-14 54.5 0.1 4.8 5 0 0 5 5 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK35630.1 - 3.4e-36 123.4 2.1 6e-11 42.5 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK35630.1 - 2.4e-33 114.1 2.5 4.5e-09 36.4 0.1 4.8 4 1 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 PIK35630.1 - 3.8e-26 91.3 0.8 7.1e-12 45.5 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 PIK35630.1 - 6.9e-25 87.3 8.0 2e-06 27.9 0.0 7.1 4 3 2 6 6 6 6 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK35630.1 - 1.6e-12 47.3 2.0 0.035 14.2 0.1 4.5 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK35630.1 - 2.7e-09 37.3 0.0 0.11 12.9 0.0 5.1 4 2 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK35630.1 - 2.3e-08 34.1 0.0 2.5 8.4 0.0 5.5 4 2 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK35630.1 - 1.4e-05 24.6 0.0 2.4 7.8 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK35630.1 - 2.4e-05 24.8 0.2 0.02 15.5 0.0 3.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C1-set PF07654.15 PIK35630.1 - 2.7e-05 24.5 2.2 0.59 10.6 0.1 4.3 4 1 0 4 4 4 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK35630.1 - 0.00032 20.7 0.0 21 5.3 0.0 4.2 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 PIK35630.1 - 0.019 15.2 0.1 38 4.5 0.0 4.2 4 1 0 4 4 4 0 Natural killer cell receptor 2B4 C2-set PF05790.15 PIK35630.1 - 0.059 13.6 0.0 42 4.4 0.0 3.7 3 0 0 3 3 3 0 Immunoglobulin C2-set domain fn3 PF00041.21 PIK35631.1 - 3.1e-26 91.5 0.5 1.6e-12 47.6 0.0 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 PIK35631.1 - 0.0014 18.9 0.0 0.15 12.4 0.0 2.2 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 PIK35631.1 - 0.0019 18.7 1.2 0.78 10.4 0.0 2.4 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Lipoprotein_8 PF02030.15 PIK35631.1 - 0.042 12.6 0.3 0.057 12.1 0.3 1.1 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) HNOBA PF07701.14 PIK35632.1 - 1.2e-44 152.4 4.9 1.8e-42 145.3 4.9 2.3 1 1 0 1 1 1 1 Heme NO binding associated Apt1 PF10351.9 PIK35632.1 - 0.035 13.0 1.2 0.054 12.4 1.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain BTB PF00651.31 PIK35633.1 - 6.2e-16 58.6 0.7 4.2e-15 55.9 0.2 2.7 3 0 0 3 3 3 1 BTB/POZ domain Ank_2 PF12796.7 PIK35633.1 - 1.1e-14 54.7 0.1 6.4e-06 26.7 0.0 3.9 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK35633.1 - 1.4e-12 47.8 0.1 1.6e-05 25.3 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK35633.1 - 3.2e-10 39.3 0.0 0.00085 19.6 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 PIK35633.1 - 3.1e-09 36.9 1.1 0.0014 19.0 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 PIK35633.1 - 5.9e-09 36.0 0.0 0.0022 18.2 0.0 4.3 2 1 2 4 4 4 2 Ankyrin repeats (many copies) BACK PF07707.15 PIK35633.1 - 0.0058 16.7 0.1 0.027 14.6 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Coatomer_g_Cpla PF16381.5 PIK35633.1 - 0.16 12.1 0.0 5.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform LMF1 PF06762.14 PIK35635.1 - 2.4e-117 392.8 4.2 9.8e-70 235.8 0.2 2.0 1 1 1 2 2 2 2 Lipase maturation factor IRK PF01007.20 PIK35636.1 - 2e-57 192.9 5.1 2.8e-57 192.5 5.1 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_C PF17655.1 PIK35636.1 - 1.3e-55 187.6 0.0 1.9e-55 187.1 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 PIK35636.1 - 0.016 15.1 6.5 0.042 13.8 6.5 1.8 1 1 0 1 1 1 0 Ion channel PNISR PF15996.5 PIK35637.1 - 0.026 14.8 7.6 0.027 14.7 7.6 1.0 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Borrelia_P83 PF05262.11 PIK35637.1 - 2.7 6.4 13.2 2.8 6.3 13.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Drf_FH3 PF06367.16 PIK35638.1 - 1e-39 136.2 11.9 3.1e-39 134.6 11.9 1.9 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 PIK35638.1 - 1e-27 96.9 1.4 1e-27 96.9 1.4 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain FH2 PF02181.23 PIK35638.1 - 2.9e-17 62.9 0.2 2.9e-17 62.9 0.2 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain DUF5052 PF16475.5 PIK35638.1 - 0.054 13.1 1.4 0.23 11.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5052) Phage_GPO PF05929.11 PIK35638.1 - 0.12 12.0 5.9 0.25 11.0 5.9 1.5 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ZapD PF07072.11 PIK35638.1 - 1.2 8.8 7.9 2.5 7.8 7.9 1.5 1 0 0 1 1 1 0 Cell division protein NDK PF00334.19 PIK35639.1 - 3.4e-13 49.8 0.0 3.6e-13 49.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.19 PIK35640.1 - 3.4e-47 159.8 0.0 1.6e-29 102.6 0.0 2.0 2 0 0 2 2 2 2 Nucleoside diphosphate kinase URO-D PF01208.17 PIK35640.1 - 0.076 12.1 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) NUC202 PF08166.12 PIK35641.1 - 5.9e-07 29.5 0.5 5.9e-07 29.5 0.5 2.0 2 0 0 2 2 2 1 NUC202 domain ZU5 PF00791.20 PIK35644.1 - 1.4e-12 47.8 0.0 2.8e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain DUF2738 PF10927.8 PIK35644.1 - 0.076 12.1 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) Fibrinogen_C PF00147.18 PIK35646.1 - 1.5e-33 116.4 15.0 2.4e-32 112.5 15.0 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK35646.1 - 3.9e-07 29.9 5.8 3.9e-07 29.9 5.8 3.9 2 1 2 4 4 4 1 TILa domain TaqI_C PF12950.7 PIK35647.1 - 0.027 14.5 1.6 22 5.2 0.0 3.6 3 0 0 3 3 3 0 TaqI-like C-terminal specificity domain Viral_DNA_bi PF02236.17 PIK35647.1 - 0.076 13.2 0.0 0.89 9.8 0.1 2.5 2 0 0 2 2 2 0 Viral DNA-binding protein, all alpha domain TMEM95 PF15203.6 PIK35647.1 - 0.078 12.6 3.7 2.5 7.7 0.4 3.0 2 1 0 2 2 2 0 TMEM95 family RHD3 PF05879.12 PIK35648.1 - 1.6e-12 46.5 0.9 2.1e-12 46.0 0.9 1.3 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK35648.1 - 8.4e-07 29.2 1.3 2.6e-06 27.6 1.3 2.0 1 1 0 1 1 1 1 Dynamin family GBP PF02263.19 PIK35648.1 - 3.8e-06 26.4 0.1 4.9e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 PIK35648.1 - 0.0002 21.4 0.1 0.00036 20.6 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DLIC PF05783.11 PIK35648.1 - 0.066 12.0 0.0 0.096 11.5 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Peptidase_C93 PF06035.11 PIK35648.1 - 0.09 12.6 0.3 0.14 11.9 0.3 1.2 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP AAA_16 PF13191.6 PIK35648.1 - 0.096 13.1 0.0 0.2 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK35648.1 - 0.33 11.5 2.3 1.2 9.6 2.3 2.0 1 1 0 1 1 1 0 ABC transporter DED PF01335.21 PIK35649.1 - 0.00085 19.6 3.4 0.001 19.3 0.5 2.6 3 0 0 3 3 3 1 Death effector domain Death PF00531.22 PIK35649.1 - 0.01 16.0 1.1 3 8.1 0.0 3.0 3 0 0 3 3 3 2 Death domain YqhR PF11085.8 PIK35649.1 - 0.16 11.9 0.6 0.29 11.0 0.1 1.7 2 0 0 2 2 2 0 Conserved membrane protein YqhR DED PF01335.21 PIK35650.1 - 1.9e-09 37.7 4.5 1.9e-09 37.7 4.5 2.5 3 0 0 3 3 3 1 Death effector domain zf-B_box PF00643.24 PIK35650.1 - 0.00023 21.3 7.0 0.00061 19.9 7.0 1.7 1 0 0 1 1 1 1 B-box zinc finger SPX PF03105.19 PIK35650.1 - 0.13 12.1 2.4 0.19 11.6 2.4 1.2 1 0 0 1 1 1 0 SPX domain RHD3 PF05879.12 PIK35651.1 - 3.2e-09 35.5 0.1 3.2e-09 35.5 0.1 2.7 3 0 0 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK35651.1 - 2.6e-06 27.6 1.1 1.5e-05 25.1 0.0 2.6 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 PIK35651.1 - 0.0013 18.8 0.0 0.0069 16.5 0.0 2.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DED PF01335.21 PIK35651.1 - 0.033 14.5 3.8 0.041 14.2 0.6 2.9 2 0 0 2 2 2 0 Death effector domain zf-UBP PF02148.19 PIK35652.1 - 1.5e-21 76.5 6.8 4.3e-21 75.0 6.8 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.12 PIK35652.1 - 4.9e-18 65.2 1.1 2.1e-17 63.1 1.1 2.0 1 1 0 1 1 1 1 BRCA1-associated protein 2 zf-RING_2 PF13639.6 PIK35652.1 - 9.1e-09 35.5 6.4 9.1e-09 35.5 6.4 3.3 3 1 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK35652.1 - 9.4e-07 28.6 5.6 9.4e-07 28.6 5.6 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK35652.1 - 1.4e-05 24.9 5.4 1.4e-05 24.9 5.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK35652.1 - 8.7e-05 22.2 3.9 8.7e-05 22.2 3.9 3.2 2 1 1 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 PIK35652.1 - 0.00011 22.1 0.4 0.00011 22.1 0.4 3.3 1 1 1 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK35652.1 - 0.00024 21.0 5.4 0.00024 21.0 5.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK35652.1 - 0.00033 20.5 13.6 0.0089 15.9 3.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK35652.1 - 0.00094 19.4 6.3 0.00094 19.4 6.3 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain Rootletin PF15035.6 PIK35652.1 - 0.0036 17.4 16.7 0.0089 16.1 16.7 1.6 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion CM1 PF03026.15 PIK35652.1 - 0.049 13.0 0.1 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Influenza C virus M1 protein Phage_GP20 PF06810.11 PIK35652.1 - 0.67 9.7 16.1 0.45 10.3 7.0 2.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 Prominin PF05478.11 PIK35652.1 - 0.84 7.5 8.1 1.2 7.0 8.1 1.2 1 0 0 1 1 1 0 Prominin zf-ANAPC11 PF12861.7 PIK35652.1 - 0.92 9.6 7.8 0.26 11.3 4.6 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UBP_var PF17807.1 PIK35652.1 - 1.6 8.6 8.0 0.24 11.2 2.8 2.3 1 1 1 2 2 2 0 Variant UBP zinc finger Zn_ribbon_17 PF17120.5 PIK35652.1 - 2.4 7.8 15.2 1.2 8.8 5.9 2.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Fib_alpha PF08702.10 PIK35652.1 - 6.7 6.9 13.9 1.6 8.9 0.8 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family APC_u14 PF16635.5 PIK35652.1 - 7.9 7.1 11.2 4.1 8.0 7.1 2.8 2 1 0 2 2 2 0 Unstructured region on APC between SAMP and APC_crr Prok-RING_4 PF14447.6 PIK35652.1 - 8.5 6.3 23.5 0.068 13.1 5.8 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Collagen PF01391.18 PIK35653.1 - 9.9e-16 57.3 63.2 4.1e-09 36.1 30.2 2.5 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) EMI PF07546.13 PIK35653.1 - 0.0003 21.5 0.1 0.00053 20.7 0.1 1.4 1 0 0 1 1 1 1 EMI domain Collagen PF01391.18 PIK35654.1 - 8.1e-59 195.3 190.1 3.3e-08 33.2 26.3 7.4 1 1 3 4 4 4 3 Collagen triple helix repeat (20 copies) FERM_C PF09380.10 PIK35655.1 - 6.5e-21 74.5 0.0 1.3e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK35655.1 - 4.5e-20 72.2 1.0 1.2e-19 70.9 0.0 2.2 2 0 0 2 2 2 1 FERM central domain FA PF08736.11 PIK35655.1 - 1e-09 38.3 12.8 3.1e-09 36.7 12.8 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) CEP1-DNA_bind PF09287.10 PIK35655.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 CEP-1, DNA binding ACBP PF00887.19 PIK35655.1 - 0.093 13.0 0.0 0.33 11.2 0.0 2.0 1 0 0 1 1 1 0 Acyl CoA binding protein Y_phosphatase PF00102.27 PIK35657.1 - 8.2e-29 100.8 0.1 1.3e-28 100.2 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PDZ PF00595.24 PIK35657.1 - 1.2e-15 57.6 0.0 1.8e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK35657.1 - 0.00045 20.0 0.0 0.00084 19.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK35657.1 - 0.1 13.0 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Smg8_Smg9 PF10220.9 PIK35658.1 - 6.8e-46 157.1 0.0 8.9e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 Smg8_Smg9 OTU PF02338.19 PIK35659.1 - 1.6e-09 38.4 0.0 5.6e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 PIK35659.1 - 2.4e-05 23.9 0.1 0.19 11.2 0.0 2.4 2 0 0 2 2 2 2 Peptidase C65 Otubain SR-25 PF10500.9 PIK35659.1 - 0.0071 16.0 1.8 0.0071 16.0 1.8 2.9 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein CUE PF02845.16 PIK35659.1 - 0.028 14.1 0.3 0.086 12.6 0.1 1.9 2 0 0 2 2 2 0 CUE domain Colicin_D PF11429.8 PIK35659.1 - 0.041 14.3 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 Colicin D UBA PF00627.31 PIK35659.1 - 0.088 12.7 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 UBA/TS-N domain Nitro_FeMo-Co PF02579.17 PIK35659.1 - 0.13 12.6 0.2 3 8.2 0.1 2.5 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor Occludin_ELL PF07303.13 PIK35659.1 - 2.3 9.0 9.2 0.39 11.5 2.1 2.6 2 0 0 2 2 2 0 Occludin homology domain zf-RING_2 PF13639.6 PIK35660.1 - 1.1e-08 35.3 4.4 1.1e-08 35.3 4.4 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK35660.1 - 2.5e-07 30.4 2.8 5.9e-07 29.3 2.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35660.1 - 3.1e-06 27.1 2.0 9.4e-06 25.6 2.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK35660.1 - 3.6e-06 26.7 2.1 7.2e-06 25.8 2.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK35660.1 - 7.1e-06 26.2 4.8 2.4e-05 24.5 4.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 PIK35660.1 - 1.1e-05 25.2 3.8 2.4e-05 24.1 3.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK35660.1 - 0.00022 21.1 3.4 0.00054 19.9 3.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK35660.1 - 0.0027 17.5 3.4 0.0083 16.0 3.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK35660.1 - 0.0039 17.3 0.7 0.0039 17.3 0.7 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 PIK35660.1 - 0.0069 16.4 1.5 0.023 14.8 1.5 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger WD40 PF00400.32 PIK35660.1 - 0.0076 17.1 0.0 8.3 7.5 0.0 3.5 2 0 0 2 2 2 1 WD domain, G-beta repeat zf-RING_11 PF17123.5 PIK35660.1 - 0.0094 15.7 1.2 0.028 14.1 1.1 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_4 PF14570.6 PIK35660.1 - 0.034 13.9 1.9 0.088 12.6 1.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FYVE PF01363.21 PIK35660.1 - 0.037 14.2 0.8 0.089 12.9 0.8 1.7 1 0 0 1 1 1 0 FYVE zinc finger BBS2_Mid PF14783.6 PIK35660.1 - 0.064 13.3 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region zf-Nse PF11789.8 PIK35660.1 - 0.081 12.8 0.3 0.18 11.6 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rhodanese_C PF12368.8 PIK35660.1 - 0.21 12.0 2.2 2.7 8.4 2.3 2.7 2 1 1 3 3 3 0 Rhodanase C-terminal Zn_ribbon_17 PF17120.5 PIK35660.1 - 0.24 11.0 3.6 0.51 10.0 3.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 PIK35660.1 - 0.57 10.4 6.8 6.4 7.0 6.8 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_6 PF14835.6 PIK35660.1 - 6.9 6.6 5.6 1.4 8.8 0.3 2.5 2 1 0 3 3 3 0 zf-RING of BARD1-type protein Ig_mannosidase PF17753.1 PIK35662.1 - 8.9e-16 57.4 1.3 8.9e-16 57.4 1.3 2.0 2 0 0 2 2 2 1 Ig-fold domain Mannosidase_ig PF17786.1 PIK35662.1 - 2e-06 28.3 0.0 5e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_N PF02837.18 PIK35662.1 - 9.3e-05 22.4 0.1 0.00024 21.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Homeodomain PF00046.29 PIK35663.1 - 4.9e-19 67.9 1.8 7.7e-19 67.3 1.8 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK35663.1 - 1.1e-05 25.3 0.2 2.3e-05 24.2 0.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK35663.1 - 0.0019 17.6 0.1 0.0034 16.8 0.1 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF2358 PF10184.9 PIK35664.1 - 1.3e-21 76.9 0.0 2.2e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) DAPDH_C PF16654.5 PIK35664.1 - 0.084 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain DSPc PF00782.20 PIK35665.1 - 4e-27 94.6 0.1 5.2e-27 94.3 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK35665.1 - 0.013 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Yippee-Mis18 PF03226.14 PIK35665.1 - 0.076 13.2 0.5 0.75 10.0 0.5 2.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_4 PF13717.6 PIK35665.1 - 0.11 12.4 1.1 12 5.9 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Laminin_G_2 PF02210.24 PIK35666.1 - 4.1e-07 30.6 0.0 5.5e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK35666.1 - 5.9e-06 26.5 0.0 9.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Fe-ADH PF00465.19 PIK35667.1 - 1e-94 317.4 0.2 5.6e-94 314.9 0.2 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 PIK35667.1 - 1.2e-13 51.4 0.1 8e-13 48.7 0.1 2.0 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 PIK35667.1 - 0.00026 20.8 0.1 0.00052 19.8 0.1 1.4 1 0 0 1 1 1 1 Periplasmic binding protein IRS PF02174.17 PIK35668.1 - 5.4e-28 96.8 0.1 2.1e-27 94.9 0.1 1.9 1 1 1 2 2 2 1 PTB domain (IRS-1 type) Peptidase_S9_N PF02897.15 PIK35670.1 - 5.5e-149 496.5 0.1 7e-149 496.1 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 PIK35670.1 - 2.3e-65 220.0 0.0 3.5e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 PIK35670.1 - 0.032 12.9 0.0 0.057 12.1 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Ras PF00071.22 PIK35671.1 - 2.6e-45 154.0 0.5 3.2e-45 153.6 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK35671.1 - 1e-11 45.1 0.0 2.1e-11 44.1 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK35671.1 - 5.9e-08 32.4 0.2 8e-08 31.9 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK35671.1 - 5.2e-05 22.9 0.1 0.0001 21.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK35671.1 - 0.0021 18.0 0.1 0.0037 17.2 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase ATP_bind_1 PF03029.17 PIK35671.1 - 0.0034 17.2 0.2 0.004 17.0 0.2 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 PIK35671.1 - 0.01 15.3 0.2 0.015 14.7 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK35671.1 - 0.054 12.8 0.4 0.062 12.7 0.4 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Leg1 PF05612.12 PIK35671.1 - 0.069 12.3 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Leg1 RR_TM4-6 PF06459.12 PIK35672.1 - 0.17 11.7 1.6 0.26 11.1 1.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 B277 PF17623.2 PIK35672.1 - 1.2 8.2 4.0 3.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF5385 PF17359.2 PIK35673.1 - 0.0018 17.9 0.5 0.0027 17.3 0.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5385) DcuC PF03606.15 PIK35673.1 - 0.0031 16.0 0.1 0.0035 15.9 0.1 1.1 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier SCIMP PF15050.6 PIK35673.1 - 0.0064 17.0 0.0 0.0081 16.6 0.0 1.1 1 0 0 1 1 1 1 SCIMP protein MAP17 PF15807.5 PIK35673.1 - 0.0092 16.2 0.1 0.0096 16.2 0.1 1.1 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EphA2_TM PF14575.6 PIK35673.1 - 0.01 16.7 0.0 0.014 16.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AA_permease_2 PF13520.6 PIK35673.1 - 0.011 14.6 1.2 0.012 14.4 1.2 1.0 1 0 0 1 1 1 0 Amino acid permease DUF4307 PF14155.6 PIK35673.1 - 0.019 14.8 1.1 0.066 13.0 1.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4307) Cadherin_C_2 PF16492.5 PIK35673.1 - 0.062 14.0 0.0 0.088 13.6 0.0 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Zip PF02535.22 PIK35673.1 - 0.1 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SARAF PF06682.12 PIK35673.1 - 0.12 12.0 0.0 0.13 11.9 0.0 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TMEM154 PF15102.6 PIK35673.1 - 0.14 12.1 2.2 0.37 10.7 2.2 1.7 1 1 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 PIK35673.1 - 9.5 6.1 8.2 2.2 8.2 4.2 1.8 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator AMOP PF03782.17 PIK35674.1 - 3.4e-40 137.5 4.0 6.2e-40 136.6 4.0 1.4 1 0 0 1 1 1 1 AMOP domain NIDO PF06119.14 PIK35674.1 - 4.4e-17 62.8 1.2 1.5e-16 61.1 1.2 2.0 1 0 0 1 1 1 1 Nidogen-like VWD PF00094.25 PIK35674.1 - 2e-11 44.4 0.3 2.2e-05 24.8 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type D domain Sushi PF00084.20 PIK35674.1 - 2.2e-05 25.0 1.5 3.4e-05 24.4 0.2 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Pkinase_Tyr PF07714.17 PIK35675.1 - 5.1e-24 85.0 0.1 6.3e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35675.1 - 6.4e-17 61.8 0.1 8.2e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK35677.1 - 0.0022 18.2 0.0 0.005 17.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK35677.1 - 0.018 15.1 0.0 0.057 13.5 0.0 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain EphA2_TM PF14575.6 PIK35677.1 - 0.14 13.1 0.2 0.47 11.4 0.3 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK35677.1 - 0.17 11.8 0.3 0.33 10.9 0.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family Lep_receptor_Ig PF06328.11 PIK35678.1 - 0.0034 17.3 0.2 0.0069 16.3 0.2 1.6 1 0 0 1 1 1 1 Ig-like C2-type domain Ank_5 PF13857.6 PIK35680.1 - 1e-14 54.4 1.2 6.5e-08 32.7 0.5 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK35680.1 - 3.5e-14 53.0 0.8 0.0001 22.8 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK35680.1 - 1.2e-13 51.5 0.3 4.3e-07 30.4 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK35680.1 - 1.5e-13 50.5 1.4 8.5e-05 22.8 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK35680.1 - 1.4e-11 43.5 0.9 0.00076 19.7 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat TSNAXIP1_N PF15739.5 PIK35681.1 - 0.00011 22.5 0.7 0.00027 21.3 0.7 1.6 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus TFA2_Winged_2 PF18121.1 PIK35681.1 - 0.027 14.2 1.0 2.5 7.9 1.3 2.5 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 Fib_alpha PF08702.10 PIK35681.1 - 0.041 14.1 1.3 0.82 9.8 0.4 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HAP1_N PF04849.13 PIK35681.1 - 0.18 11.0 7.5 0.064 12.5 4.9 1.5 2 0 0 2 2 2 0 HAP1 N-terminal conserved region bZIP_2 PF07716.15 PIK35681.1 - 0.45 10.6 2.8 1.2 9.3 2.8 1.7 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.15 PIK35682.1 - 0.015 15.1 0.7 0.034 13.9 0.7 1.6 1 0 0 1 1 1 0 Septum formation initiator ADIP PF11559.8 PIK35682.1 - 0.048 13.7 0.5 0.24 11.5 0.9 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TSNAXIP1_N PF15739.5 PIK35682.1 - 0.092 13.1 3.0 0.095 13.1 1.6 1.8 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus RVT_1 PF00078.27 PIK35683.1 - 4.3e-30 104.9 0.1 5.5e-30 104.5 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L4 PF00573.22 PIK35684.1 - 3.1e-40 137.9 0.3 3.1e-40 137.9 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 PIK35684.1 - 3.2e-22 78.4 5.4 3.2e-22 78.4 5.4 2.7 3 0 0 3 3 3 1 60S ribosomal protein L4 C-terminal domain COesterase PF00135.28 PIK35685.1 - 1.2e-09 37.6 0.1 1.5e-09 37.3 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family Methyltransf_11 PF08241.12 PIK35686.1 - 8.5e-10 39.2 0.0 1.2e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK35686.1 - 8.9e-08 32.7 0.0 1.2e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK35686.1 - 0.00085 20.0 0.0 0.0013 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK35686.1 - 0.015 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK35686.1 - 0.027 14.3 0.1 0.04 13.8 0.1 1.3 1 1 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 PIK35686.1 - 0.092 12.3 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) 2OG-FeII_Oxy_2 PF13532.6 PIK35687.1 - 2.3e-22 80.1 0.0 3.5e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 PIK35687.1 - 1.1e-10 41.2 0.0 3.1e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 2OG-FeII_Oxy PF03171.20 PIK35687.1 - 0.0035 17.8 0.0 0.0078 16.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_occluded PF16842.5 PIK35687.1 - 0.05 13.5 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif BTB PF00651.31 PIK35688.1 - 1.4e-35 121.8 1.2 1.7e-34 118.3 0.3 2.4 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK35688.1 - 0.0014 18.7 0.1 0.15 12.2 0.0 2.5 2 0 0 2 2 2 2 BTB And C-terminal Kelch Skp1_POZ PF03931.15 PIK35688.1 - 0.0054 16.9 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Phage_integrase PF00589.22 PIK35689.1 - 0.088 12.6 0.0 0.17 11.6 0.0 1.4 2 0 0 2 2 2 0 Phage integrase family EURL PF06937.11 PIK35690.1 - 6.1e-07 29.1 9.2 0.0016 17.9 1.2 2.3 2 0 0 2 2 2 2 EURL protein FEZ PF07763.13 PIK35690.1 - 0.00061 19.6 0.5 0.0011 18.8 0.5 1.5 1 0 0 1 1 1 1 FEZ-like protein RecR PF02132.15 PIK35690.1 - 0.53 9.9 3.9 0.24 11.0 0.4 2.2 1 1 1 2 2 2 0 RecR protein BOP1NT PF08145.12 PIK35693.1 - 2.9e-60 204.4 29.0 5e-60 203.6 0.2 3.2 2 1 1 3 3 3 2 BOP1NT (NUC169) domain WD40 PF00400.32 PIK35693.1 - 1.9e-21 76.0 3.9 0.0018 19.1 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK35693.1 - 0.00087 19.5 0.0 24 5.3 0.0 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nop53 PF07767.11 PIK35693.1 - 1 8.7 25.3 1.5 8.2 21.0 2.4 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) V_ATPase_I PF01496.19 PIK35693.1 - 3 5.6 3.8 4.6 5.0 3.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ARGLU PF15346.6 PIK35693.1 - 4.8 7.0 27.3 9.3 6.1 27.3 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Ig_3 PF13927.6 PIK35694.1 - 0.068 13.8 2.4 0.9 10.2 0.7 2.9 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK35694.1 - 0.11 12.7 1.3 0.24 11.6 0.2 2.2 2 0 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK35694.1 - 2.3 8.3 7.5 0.38 10.8 0.2 3.2 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain TILa PF12714.7 PIK35695.1 - 1.2e-10 41.2 10.8 1.2e-10 41.2 10.8 3.5 1 1 2 3 3 3 1 TILa domain Fibrinogen_C PF00147.18 PIK35695.1 - 3.4e-07 30.3 0.0 6.4e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK35695.1 - 1.2e-05 25.5 13.3 1.2e-05 25.5 13.3 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK35695.1 - 0.00049 20.2 9.4 0.00049 20.2 9.4 4.0 2 2 1 3 3 3 1 EGF domain Tme5_EGF_like PF09064.10 PIK35695.1 - 0.018 15.0 7.2 0.018 15.0 7.2 3.7 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like EGF_MSP1_1 PF12946.7 PIK35695.1 - 1.4 9.0 29.9 0.085 12.9 8.3 3.5 3 1 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK35696.1 - 1.1e-78 264.0 22.2 3.3e-39 135.0 16.9 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK35696.1 - 2.1e-06 27.9 16.1 2.1e-06 27.9 16.1 2.9 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Ig_3 PF13927.6 PIK35697.1 - 3.9e-06 27.4 0.5 6.5e-06 26.7 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK35697.1 - 4e-05 23.8 0.1 4.6e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK35697.1 - 0.00072 19.8 1.8 0.0014 18.9 1.8 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK35697.1 - 0.002 17.6 0.0 0.0047 16.5 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK35697.1 - 0.021 14.9 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35698.1 - 2.7e-08 34.3 0.3 0.0044 17.6 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK35698.1 - 2.5e-07 30.9 1.4 0.012 15.9 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK35698.1 - 2.8e-06 27.4 2.0 0.014 15.5 0.5 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK35698.1 - 1.9e-05 24.6 0.6 0.022 14.8 0.0 2.9 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK35698.1 - 7.1e-05 22.9 0.3 0.019 15.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain DUF1496 PF07383.12 PIK35698.1 - 0.052 13.1 0.0 15 5.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1496) C2-set PF05790.15 PIK35698.1 - 0.078 13.2 0.0 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin C2-set domain Ig_3 PF13927.6 PIK35699.1 - 3.9e-29 101.1 0.2 1.9e-13 50.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK35699.1 - 3.3e-25 88.0 0.0 1.6e-12 47.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK35699.1 - 1.1e-23 83.3 1.1 1.7e-13 50.7 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK35699.1 - 3.7e-15 55.9 0.1 1.1e-05 25.5 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK35699.1 - 1.7e-07 31.2 0.0 0.091 12.8 0.0 3.6 3 1 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK35699.1 - 0.00082 19.5 1.2 5.5 7.2 0.1 3.9 3 1 1 4 4 4 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK35699.1 - 0.0016 18.5 0.1 2.8 8.1 0.0 3.1 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK35700.1 - 3.1e-69 233.2 0.0 3.6e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK35700.1 - 4.2e-31 108.3 0.0 1.9e-16 60.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Haspin_kinase PF12330.8 PIK35700.1 - 0.027 13.4 0.0 0.051 12.5 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain IL2 PF00715.17 PIK35701.1 - 0.11 12.5 0.3 13 5.7 0.0 2.8 2 1 1 3 3 3 0 Interleukin 2 DUF746 PF05344.11 PIK35703.1 - 0.048 13.5 0.0 0.54 10.1 0.0 2.4 3 0 0 3 3 3 0 Domain of Unknown Function (DUF746) STPPase_N PF16891.5 PIK35703.1 - 0.11 13.0 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain HTH_44 PF14641.6 PIK35704.1 - 0.038 14.4 0.2 0.066 13.7 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 Ephrin_rec_like PF07699.13 PIK35706.1 - 0.0011 18.6 10.7 0.047 13.5 0.9 2.8 1 1 1 2 2 2 2 Putative ephrin-receptor like Cadherin_C_2 PF16492.5 PIK35706.1 - 0.15 12.8 0.1 0.44 11.3 0.1 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Ephrin_rec_like PF07699.13 PIK35707.1 - 0.00056 19.6 169.2 0.0075 16.0 11.6 16.5 10 7 7 18 18 18 10 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 PIK35708.1 - 0.00066 19.4 6.7 0.00066 19.4 6.7 6.8 2 2 4 6 6 6 1 Putative ephrin-receptor like CC PF04942.14 PIK35708.1 - 0.57 10.4 0.1 0.57 10.4 0.1 7.8 8 2 1 9 9 9 0 CC domain Opy2 PF09463.10 PIK35708.1 - 0.72 10.2 42.1 0.82 10.0 0.4 7.1 5 1 2 7 7 7 0 Opy2 protein Ephrin_rec_like PF07699.13 PIK35709.1 - 0.00012 21.8 29.9 0.00021 21.0 2.9 68.1 46 22 24 71 71 71 44 Putative ephrin-receptor like NCD3G PF07562.14 PIK35711.1 - 4.4e-07 29.8 61.9 0.0057 16.6 3.4 8.4 4 3 5 9 9 9 6 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 PIK35711.1 - 9.4e-06 25.3 94.0 0.032 14.0 8.1 9.1 1 1 3 8 8 8 7 Putative ephrin-receptor like TNFR_c6 PF00020.18 PIK35711.1 - 6 7.4 71.5 0.74 10.3 0.6 9.6 5 4 4 9 9 9 0 TNFR/NGFR cysteine-rich region C2 PF00168.30 PIK35712.1 - 0.018 15.3 0.1 0.62 10.4 0.0 2.7 3 0 0 3 3 3 0 C2 domain BBS2_Mid PF14783.6 PIK35714.1 - 6.3e-08 32.6 0.1 8.3e-08 32.2 0.1 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region PHTB1_N PF14727.6 PIK35714.1 - 0.00028 20.4 0.1 0.00037 20.0 0.1 1.2 1 0 0 1 1 1 1 PTHB1 N-terminus TcfC PF16967.5 PIK35714.1 - 0.026 14.0 0.0 0.052 13.0 0.0 1.5 1 0 0 1 1 1 0 E-set like domain BBS1 PF14779.6 PIK35715.1 - 3.6e-56 190.4 0.0 4.3e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 1 BBS2_Mid PF14783.6 PIK35715.1 - 0.0094 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region Ald_Xan_dh_C2 PF02738.18 PIK35717.1 - 5.5e-75 252.9 0.0 6.8e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase DPBB_1 PF03330.18 PIK35717.1 - 0.053 13.8 0.1 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Lytic transglycolase Carn_acyltransf PF00755.20 PIK35718.1 - 2.2e-110 370.1 0.0 2.5e-110 369.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RT_RNaseH_2 PF17919.1 PIK35719.1 - 2.2e-32 111.1 0.0 5.4e-32 109.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK35719.1 - 2.4e-26 92.6 0.0 4.5e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK35719.1 - 5.2e-26 91.0 0.0 1.1e-25 89.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK35719.1 - 9e-20 71.0 0.0 2.1e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK35719.1 - 8.7e-19 67.4 0.3 2.6e-18 65.9 0.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK35719.1 - 0.00011 22.4 0.0 0.00036 20.7 0.0 2.0 1 0 0 1 1 1 1 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK35719.1 - 0.00032 21.0 0.0 0.0011 19.2 0.0 1.9 1 0 0 1 1 1 1 DDE domain RVT_thumb PF06817.14 PIK35719.1 - 0.0011 18.7 0.1 0.0042 16.9 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase thumb domain rve_3 PF13683.6 PIK35719.1 - 0.031 14.0 0.0 0.077 12.8 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Redoxin PF08534.10 PIK35719.1 - 0.068 12.9 0.0 6.4 6.5 0.0 2.5 2 0 0 2 2 2 0 Redoxin Glyco_transf_29 PF00777.18 PIK35720.1 - 7.5e-23 81.3 0.2 1e-22 80.8 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Peptidase_C13 PF01650.18 PIK35721.1 - 4.6e-19 68.9 0.3 5.9e-19 68.6 0.3 1.1 1 0 0 1 1 1 1 Peptidase C13 family Peptidase_C13 PF01650.18 PIK35722.1 - 3.7e-10 39.8 0.1 3.9e-10 39.7 0.1 1.0 1 0 0 1 1 1 1 Peptidase C13 family ADK PF00406.22 PIK35723.1 - 6e-125 412.7 1.4 1.7e-45 154.8 0.0 4.4 4 0 0 4 4 4 4 Adenylate kinase AAA_17 PF13207.6 PIK35723.1 - 1.6e-86 287.6 12.7 2.4e-32 112.2 0.1 4.5 4 0 0 4 4 4 4 AAA domain AAA_18 PF13238.6 PIK35723.1 - 2.7e-23 82.9 1.5 4.9e-08 33.6 0.0 4.7 4 0 0 4 4 4 3 AAA domain AAA_33 PF13671.6 PIK35723.1 - 1.1e-19 71.1 0.6 0.0001 22.5 0.0 5.8 4 3 0 4 4 4 4 AAA domain AAA_28 PF13521.6 PIK35723.1 - 3.4e-08 33.9 0.7 0.68 10.2 0.0 4.5 4 0 0 4 4 4 3 AAA domain AAA_19 PF13245.6 PIK35723.1 - 1.1e-07 32.2 0.3 2 8.7 0.1 4.6 4 0 0 4 4 4 2 AAA domain Hydin_ADK PF17213.3 PIK35723.1 - 5.1e-07 30.2 4.2 0.74 10.1 0.0 5.4 5 0 0 5 5 5 2 Hydin Adenylate kinase-like domain Zeta_toxin PF06414.12 PIK35723.1 - 9.5e-07 28.3 9.7 0.0016 17.8 0.5 4.3 5 0 0 5 5 4 2 Zeta toxin AAA_22 PF13401.6 PIK35723.1 - 5.7e-06 26.7 0.2 2.5 8.4 0.0 4.4 4 0 0 4 4 4 2 AAA domain Cytidylate_kin PF02224.18 PIK35723.1 - 7.7e-06 25.8 0.1 0.083 12.6 0.0 3.9 4 1 0 4 4 4 2 Cytidylate kinase Ploopntkinase3 PF18751.1 PIK35723.1 - 3.3e-05 23.9 0.0 17 5.3 0.0 4.8 5 0 0 5 5 5 0 P-loop Nucleotide Kinase3 CobU PF02283.16 PIK35723.1 - 4e-05 23.2 0.5 0.24 11.0 0.0 4.6 5 0 0 5 5 5 1 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA PF00004.29 PIK35723.1 - 0.00023 21.6 1.3 0.64 10.4 0.3 4.2 4 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 PIK35723.1 - 0.00028 20.6 9.4 0.086 12.5 0.1 5.4 6 0 0 6 6 6 1 Thymidylate kinase Sigma54_activ_2 PF14532.6 PIK35723.1 - 0.0018 18.4 0.1 5.7 7.1 0.0 3.4 3 0 0 3 3 3 2 Sigma-54 interaction domain NTPase_1 PF03266.15 PIK35723.1 - 0.0057 16.6 0.1 2.5 8.0 0.0 3.6 4 0 0 4 4 4 1 NTPase NB-ARC PF00931.22 PIK35723.1 - 0.011 14.9 1.0 8.9 5.4 0.0 4.1 4 0 0 4 4 4 0 NB-ARC domain AAA_5 PF07728.14 PIK35723.1 - 0.039 14.0 0.8 6.5 6.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 PIK35723.1 - 0.078 13.5 2.0 7.4 7.1 0.0 4.3 4 1 0 4 4 4 0 ABC transporter Viral_helicase1 PF01443.18 PIK35723.1 - 0.088 12.5 0.4 2 8.1 0.0 2.8 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin2 PF13189.6 PIK35723.1 - 0.13 12.4 5.8 11 6.1 0.1 4.5 5 0 0 5 5 5 0 Cytidylate kinase-like family AAA_16 PF13191.6 PIK35723.1 - 3.2 8.1 6.6 15 5.9 0.1 4.3 4 2 0 4 4 4 0 AAA ATPase domain Sad1_UNC PF07738.13 PIK35724.1 - 2e-26 92.5 0.0 4.4e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal ACT_6 PF13740.6 PIK35724.1 - 0.015 15.3 0.1 0.043 13.8 0.1 1.7 1 0 0 1 1 1 0 ACT domain dNK PF01712.19 PIK35724.1 - 0.016 15.1 0.5 0.033 14.0 0.5 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase Baculo_PEP_C PF04513.12 PIK35724.1 - 0.042 13.9 1.2 0.084 12.9 1.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LOH1CR12 PF10158.9 PIK35724.1 - 0.14 12.2 2.3 0.58 10.2 2.3 2.0 1 1 0 1 1 1 0 Tumour suppressor protein DarA_N PF18788.1 PIK35724.1 - 2.5 8.2 4.9 0.72 10.0 0.9 2.1 2 0 0 2 2 2 0 Defence against restriction A N-terminal PIN_12 PF16289.5 PIK35724.1 - 3.2 8.2 13.2 0.071 13.6 3.4 2.9 3 0 0 3 3 3 0 PIN domain Pkinase PF00069.25 PIK35726.1 - 4.1e-19 69.0 0.0 6.3e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35726.1 - 7.9e-11 41.7 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Exo_endo_phos PF03372.23 PIK35727.1 - 2.6e-10 40.2 1.7 4.6e-10 39.4 0.4 2.0 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Glycos_transf_2 PF00535.26 PIK35728.1 - 7.6e-15 55.1 0.0 1.1e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 PIK35728.1 - 5.9e-05 22.6 0.1 9.6e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK35728.1 - 0.015 14.8 0.0 5.3 6.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Pyridoxal_deC PF00282.19 PIK35729.1 - 3.6e-87 292.5 0.0 4.4e-87 292.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 PIK35729.1 - 4.5e-14 52.4 0.0 6.1e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 PIK35729.1 - 1.2e-08 34.1 0.0 1.6e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_5 PF00266.19 PIK35729.1 - 8.1e-07 28.3 0.0 1.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK35729.1 - 0.082 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II OKR_DC_1 PF01276.20 PIK35729.1 - 0.092 11.5 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain C2 PF00168.30 PIK35730.1 - 1.6e-51 172.8 0.1 4.6e-22 78.3 0.0 3.5 3 0 0 3 3 3 3 C2 domain SMP_LBD PF17047.5 PIK35730.1 - 2.7e-51 173.6 0.1 4.7e-51 172.8 0.1 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain KH_6 PF15985.5 PIK35731.1 - 8.6e-14 51.6 0.3 2e-13 50.4 0.3 1.7 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 PIK35731.1 - 3.5e-06 26.8 0.0 6.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain MBF2 PF15868.5 PIK35732.1 - 5.7e-15 55.6 0.0 8.9e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Transcription activator MBF2 Death PF00531.22 PIK35732.1 - 2.6e-07 30.7 0.0 3.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Death domain MRP-S34 PF16053.5 PIK35732.1 - 0.042 13.5 0.0 0.065 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 DUF3363 PF11843.8 PIK35732.1 - 0.05 12.6 0.1 1.8 7.4 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3363) COesterase PF00135.28 PIK35733.1 - 3.8e-46 158.0 0.1 4.8e-46 157.7 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK35735.1 - 3.5e-27 95.4 0.0 4e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family RUN PF02759.19 PIK35736.1 - 3.4e-06 27.0 0.3 1.5e-05 25.0 0.3 2.0 1 0 0 1 1 1 1 RUN domain zf-RING_9 PF13901.6 PIK35737.1 - 2.2e-32 112.7 1.5 3.7e-32 112.0 1.5 1.3 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon zf-RING_7 PF02591.15 PIK35737.1 - 0.086 13.0 5.6 0.26 11.5 5.6 1.9 1 1 0 1 1 1 0 C4-type zinc ribbon domain FYVE PF01363.21 PIK35737.1 - 1.4 9.1 9.0 2.3 8.4 8.6 1.6 1 1 0 1 1 1 0 FYVE zinc finger Dicty_CAR PF05462.11 PIK35738.1 - 2.3e-18 66.4 12.3 3e-18 66.0 12.3 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 PIK35738.1 - 1.6e-09 37.7 2.4 2e-09 37.4 0.0 2.4 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term Git3 PF11710.8 PIK35738.1 - 5.2e-08 32.9 22.3 5.2e-08 32.9 22.3 2.0 2 1 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Pkinase PF00069.25 PIK35739.1 - 3.4e-13 49.6 0.1 4.3e-13 49.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35739.1 - 1e-08 34.8 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 PIK35739.1 - 0.0097 16.1 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 PIK35740.1 - 6.8e-45 153.5 0.0 1.8e-44 152.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK35740.1 - 1.9e-33 115.9 0.0 2.7e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK35740.1 - 3.6e-06 26.0 0.1 8.3e-06 24.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase DUF1241 PF06840.11 PIK35740.1 - 0.00083 19.0 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Seadorna_VP7 PF07387.11 PIK35740.1 - 0.0086 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 PIK35740.1 - 0.044 13.1 0.0 0.082 12.2 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Elongin_A PF06881.11 PIK35740.1 - 0.049 14.1 0.4 0.13 12.8 0.1 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Prp19 PF08606.11 PIK35741.1 - 0.006 16.6 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like KASH_CCD PF14662.6 PIK35741.1 - 0.022 14.6 5.0 0.036 13.9 5.0 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GIT_CC PF16559.5 PIK35741.1 - 0.2 11.5 3.9 0.21 11.5 0.8 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor IFT57 PF10498.9 PIK35741.1 - 3.2 6.6 11.1 0.078 11.9 3.2 2.0 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 Phage_integrase PF00589.22 PIK35742.1 - 0.0096 15.7 0.0 0.023 14.5 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family RVT_1 PF00078.27 PIK35743.1 - 2.1e-18 66.7 0.0 5.5e-18 65.3 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK35743.1 - 1.8e-05 25.0 0.1 0.00011 22.4 0.1 2.3 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK35743.1 - 0.00038 20.2 0.2 0.00078 19.3 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK35743.1 - 0.047 13.7 0.0 0.27 11.3 0.0 2.3 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Raftlin PF15250.6 PIK35744.1 - 0.029 13.1 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Raftlin BTB_2 PF02214.22 PIK35746.1 - 5.5e-15 55.5 0.0 1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.32 PIK35746.1 - 0.0004 21.1 2.3 4.7 8.2 0.1 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat RasGAP PF00616.19 PIK35747.1 - 3e-13 50.0 0.4 1.1e-10 41.6 0.2 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 PIK35747.1 - 0.00019 21.7 1.2 0.01 16.1 0.1 2.4 1 1 1 2 2 2 2 C2 domain C2 PF00168.30 PIK35748.1 - 6.6e-22 77.7 0.3 1.5e-17 63.8 0.0 2.5 3 0 0 3 3 3 2 C2 domain SOXp PF12336.8 PIK35749.1 - 0.0027 18.7 3.3 0.0046 18.0 3.4 1.7 1 1 0 1 1 1 1 SOX transcription factor DUF2226 PF09987.9 PIK35751.1 - 0.014 14.8 0.3 0.073 12.4 0.2 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) GrpE PF01025.19 PIK35751.1 - 0.027 14.2 0.1 0.063 12.9 0.0 1.6 2 0 0 2 2 2 0 GrpE NPV_P10 PF05531.12 PIK35751.1 - 0.03 14.8 1.2 0.26 11.8 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Flavi_NS2A PF01005.19 PIK35751.1 - 0.035 14.3 3.1 7.6 6.6 0.0 2.2 2 0 0 2 2 2 0 Flavivirus non-structural protein NS2A Apolipoprotein PF01442.18 PIK35751.1 - 0.14 12.0 1.7 1.1 9.1 0.3 2.1 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain ABC2_membrane_2 PF12679.7 PIK35751.1 - 0.21 10.9 2.5 0.29 10.4 2.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein COPI_assoc PF08507.10 PIK35751.1 - 0.87 9.6 6.0 1.5 8.9 6.0 1.3 1 0 0 1 1 1 0 COPI associated protein Mer2 PF09074.10 PIK35751.1 - 0.93 9.3 5.0 13 5.5 0.2 2.7 2 1 0 2 2 2 0 Mer2 MgtE PF01769.16 PIK35751.1 - 1.1 9.6 5.3 2.5 8.5 5.3 1.6 1 0 0 1 1 1 0 Divalent cation transporter CH PF00307.31 PIK35752.1 - 2.2e-17 63.2 0.0 3.8e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Smoothelin PF12510.8 PIK35752.1 - 3.2e-14 52.7 2.1 3.2e-14 52.7 2.1 2.5 3 0 0 3 3 3 1 Smoothelin cytoskeleton protein CAMSAP_CH PF11971.8 PIK35752.1 - 5.8e-06 26.1 0.1 1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 CAMSAP CH domain DUF3987 PF13148.6 PIK35752.1 - 0.017 14.1 3.9 0.033 13.2 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Phage_int_SAM_1 PF02899.17 PIK35753.1 - 0.00012 22.4 1.0 0.0003 21.0 0.1 2.1 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK35753.1 - 0.00038 20.9 0.0 0.00079 19.9 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK35753.1 - 0.00061 19.6 0.0 0.0021 17.8 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family zf-CCHC_5 PF14787.6 PIK35755.1 - 0.00057 19.5 5.4 0.0012 18.5 5.4 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger APCDDC PF14921.6 PIK35755.1 - 0.003 17.1 0.4 0.0039 16.7 0.4 1.3 1 0 0 1 1 1 1 Adenomatosis polyposis coli down-regulated 1 zf-CCHC PF00098.23 PIK35755.1 - 0.0087 16.1 4.1 0.0087 16.1 4.1 3.0 3 0 0 3 3 3 1 Zinc knuckle ATPgrasp_TupA PF14305.6 PIK35755.1 - 0.08 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 TupA-like ATPgrasp SnoaL_3 PF13474.6 PIK35755.1 - 0.18 12.1 0.7 0.35 11.1 0.1 1.8 2 0 0 2 2 2 0 SnoaL-like domain zf-CCHC_4 PF14392.6 PIK35755.1 - 1 9.1 6.7 2.5 7.9 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle SID-1_RNA_chan PF13965.6 PIK35757.1 - 3e-39 135.0 0.1 3.8e-39 134.6 0.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 IL4_i_Ig PF18258.1 PIK35757.1 - 0.17 12.1 0.2 0.61 10.3 0.0 2.0 2 0 0 2 2 2 0 Interleukin-4 inducing immunoglobulin-binding domain UCH PF00443.29 PIK35758.1 - 7.7e-18 64.9 1.2 8.3e-18 64.8 1.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK35758.1 - 3.4e-05 23.6 0.3 3.4e-05 23.6 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CDC14 PF08045.11 PIK35759.1 - 0.055 12.6 0.3 0.088 11.9 0.2 1.3 1 1 0 1 1 1 0 Cell division control protein 14, SIN component Mis12 PF05859.12 PIK35759.1 - 0.076 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Mis12 protein Paf67 PF10255.9 PIK35760.1 - 1.6e-94 317.2 0.3 2.1e-94 316.8 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 PIK35760.1 - 0.00082 19.3 0.1 0.024 14.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Herpes_ori_bp PF02399.15 PIK35760.1 - 0.013 13.6 0.0 0.022 12.8 0.0 1.3 1 0 0 1 1 1 0 Origin of replication binding protein TPR_1 PF00515.28 PIK35760.1 - 0.015 15.1 0.0 0.066 13.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat EamA PF00892.20 PIK35761.1 - 9.3e-14 51.8 6.6 9.3e-14 51.8 6.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family CCB1 PF12046.8 PIK35761.1 - 0.1 11.9 1.7 0.31 10.4 1.7 1.7 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B Ank_4 PF13637.6 PIK35762.1 - 7.9e-37 125.2 20.3 1.8e-09 37.9 0.1 7.1 4 1 5 9 9 9 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK35762.1 - 1.4e-30 105.7 16.0 1.4e-15 57.6 1.2 4.7 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 PIK35762.1 - 8e-27 92.5 19.2 4.1e-06 27.0 0.0 7.5 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 PIK35762.1 - 1.2e-24 83.7 10.2 2e-05 24.6 0.1 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 PIK35762.1 - 4.7e-22 77.8 14.2 2.3e-06 27.7 0.1 6.9 3 3 3 6 6 6 5 Ankyrin repeats (many copies) MULE PF10551.9 PIK35763.1 - 0.0072 16.7 0.2 0.047 14.1 0.0 2.4 3 0 0 3 3 3 1 MULE transposase domain NPHI_C PF08469.10 PIK35763.1 - 0.035 14.1 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal THAP PF05485.12 PIK35764.1 - 0.0035 18.2 0.2 3.5 8.6 0.0 3.0 2 1 1 3 3 3 2 THAP domain RNase_HII PF01351.18 PIK35765.1 - 0.15 11.9 0.7 0.37 10.6 0.1 1.9 2 0 0 2 2 2 0 Ribonuclease HII p450 PF00067.22 PIK35767.1 - 4.8e-69 233.3 0.2 5.5e-69 233.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK35768.1 - 2.6e-65 221.0 0.1 2.9e-65 220.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 His_Phos_2 PF00328.22 PIK35769.1 - 2.2e-26 93.1 0.0 3.5e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Acyl-CoA_dh_1 PF00441.24 PIK35770.1 - 3.3e-41 141.0 0.4 5.5e-41 140.3 0.2 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK35770.1 - 3.5e-27 94.5 0.0 7.4e-27 93.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK35770.1 - 1.1e-25 90.5 0.2 3.6e-25 88.8 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK35770.1 - 3.8e-11 43.4 0.0 6.4e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain vATP-synt_E PF01991.18 PIK35771.1 - 5.8e-19 68.3 0.9 6.1e-19 68.2 0.9 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Flagellin_N PF00669.20 PIK35771.1 - 0.08 13.0 0.1 0.088 12.9 0.1 1.1 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Homeobox_KN PF05920.11 PIK35774.1 - 5.1e-19 67.9 1.4 8.6e-19 67.2 1.4 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 PIK35774.1 - 1.7e-07 31.0 0.2 2.9e-07 30.2 0.2 1.3 1 0 0 1 1 1 1 Homeodomain RIF5_SNase_1 PF18187.1 PIK35775.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 TbRIF5 SNase domain 1 Lectin_C PF00059.21 PIK35776.1 - 1.2e-07 32.5 1.5 1.5e-07 32.1 0.1 1.8 2 1 0 2 2 2 1 Lectin C-type domain SRCR PF00530.18 PIK35776.1 - 0.09 13.3 2.3 0.5 10.9 0.2 2.4 1 1 2 3 3 3 0 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK35777.1 - 4.3e-17 62.4 0.0 5.2e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK35777.1 - 0.086 13.4 0.5 0.12 12.9 0.5 1.5 1 1 0 1 1 1 0 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK35778.1 - 1e-39 135.1 7.6 1.6e-23 83.1 3.3 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK35778.1 - 3.9e-08 33.7 2.9 0.00052 20.5 0.8 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK35778.1 - 2e-05 25.1 1.3 0.094 13.2 0.5 2.7 1 1 2 3 3 3 2 Hepsin, SRCR domain IgGFc_binding PF17517.2 PIK35779.1 - 6.9e-34 117.4 1.0 9.7e-34 117.0 1.0 1.1 1 0 0 1 1 1 1 IgGFc binding protein rve PF00665.26 PIK35780.1 - 3.7e-19 69.1 0.1 5e-19 68.6 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK35780.1 - 0.0024 17.6 0.0 0.0037 17.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK35780.1 - 0.0069 16.6 0.1 0.0081 16.4 0.1 1.1 1 0 0 1 1 1 1 DDE domain DDE_Tnp_ISL3 PF01610.17 PIK35780.1 - 0.053 13.2 0.1 0.067 12.9 0.1 1.2 1 0 0 1 1 1 0 Transposase MgsA_C PF12002.8 PIK35780.1 - 0.057 13.4 0.0 0.072 13.0 0.0 1.1 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal Cys_box PF17869.1 PIK35780.1 - 0.084 13.0 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Anosmin cysteine rich domain SH2 PF00017.24 PIK35781.1 - 8e-09 35.5 0.0 1.8e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain COMM_domain PF07258.14 PIK35782.1 - 2e-15 56.6 0.1 5.3e-15 55.3 0.1 1.7 2 0 0 2 2 2 1 COMM domain SDH_beta PF03315.15 PIK35782.1 - 0.14 12.6 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Serine dehydratase beta chain DUF4728 PF15860.5 PIK35785.1 - 0.01 16.5 17.0 0.01 16.5 17.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) STT3 PF02516.14 PIK35785.1 - 0.26 10.1 8.3 0.3 10.0 8.3 1.2 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Neurensin PF14927.6 PIK35785.1 - 2.6 7.8 5.8 5.4 6.7 5.6 1.7 1 1 0 1 1 1 0 Neurensin Tetraspanin PF00335.20 PIK35785.1 - 5.3 6.7 16.1 0.56 9.9 10.2 2.0 1 1 0 2 2 2 0 Tetraspanin family Cpn60_TCP1 PF00118.24 PIK35786.1 - 1.5e-41 142.6 0.7 1.9e-41 142.2 0.7 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 PIK35786.1 - 0.22 11.0 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat Cpn60_TCP1 PF00118.24 PIK35787.1 - 3.3e-89 299.8 6.7 4.1e-89 299.5 6.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CH PF00307.31 PIK35788.1 - 8.1e-13 48.5 0.0 1.3e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain zf-C2H2_4 PF13894.6 PIK35789.1 - 1.4e-11 44.2 39.3 0.003 18.3 1.5 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35789.1 - 1.6e-09 37.7 38.4 0.0029 18.0 0.9 5.3 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK35789.1 - 2.6e-05 24.4 25.1 0.057 13.9 0.2 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK35789.1 - 0.00057 20.1 24.2 0.0011 19.2 0.1 4.8 4 1 1 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK35789.1 - 0.0038 17.6 19.9 0.082 13.3 0.2 5.1 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK35789.1 - 0.0043 17.0 30.9 0.057 13.4 0.6 5.0 5 0 0 5 5 5 3 C2H2-type zinc finger DUF1062 PF06353.12 PIK35789.1 - 0.051 14.4 0.8 14 6.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1062) zf_C2H2_ZHX PF18387.1 PIK35789.1 - 0.12 12.1 5.9 3 7.6 0.0 3.6 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Desulfoferrod_N PF06397.12 PIK35789.1 - 0.24 11.1 0.2 0.24 11.1 0.2 3.1 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-CHCC PF10276.9 PIK35789.1 - 2.4 8.3 12.8 6.4 6.9 0.0 4.9 5 0 0 5 5 5 0 Zinc-finger domain rve PF00665.26 PIK35791.1 - 3e-23 82.2 0.0 1.1e-22 80.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Retrotran_gag_2 PF14223.6 PIK35791.1 - 6.6e-18 64.7 0.1 1.6e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type KDZ PF18758.1 PIK35791.1 - 1.5e-07 31.2 0.1 1.5e-07 31.2 0.1 2.2 2 0 0 2 2 2 1 Kyakuja-Dileera-Zisupton transposase zf-CCHC PF00098.23 PIK35791.1 - 1.5e-05 24.8 0.6 7e-05 22.7 0.6 2.2 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK35791.1 - 0.046 13.5 0.5 0.2 11.4 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain HepII_C PF18675.1 PIK35791.1 - 0.19 11.9 0.1 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Heparinase II C-terminal domain Dimer_Tnp_hAT PF05699.14 PIK35792.1 - 7.1e-19 67.4 0.0 2.1e-18 65.9 0.0 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.15 PIK35792.1 - 2.5e-07 30.6 0.0 4.7e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 BED zinc finger DUF659 PF04937.15 PIK35792.1 - 7.6e-05 22.6 0.9 0.00014 21.8 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) DBD_Tnp_Hermes PF10683.9 PIK35792.1 - 0.014 15.0 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain zf-H2C2_5 PF13909.6 PIK35792.1 - 0.21 11.4 0.7 0.56 10.0 0.7 1.8 1 0 0 1 1 1 0 C2H2-type zinc-finger domain RVT_2 PF07727.14 PIK35793.1 - 5.1e-37 127.8 0.0 6.8e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK35794.1 - 1e-23 84.3 0.1 1.5e-23 83.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) OS-D PF03392.13 PIK35795.1 - 0.04 14.0 0.1 0.14 12.2 0.1 2.0 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D Treacle PF03546.14 PIK35796.1 - 0.056 12.3 0.6 0.071 11.9 0.6 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle HLH PF00010.26 PIK35797.1 - 5.2e-14 51.9 1.3 7.7e-14 51.4 0.5 1.7 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 PIK35797.1 - 1.2e-10 41.4 0.1 3e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 Hairy Orange zf-C2H2 PF00096.26 PIK35799.1 - 4.2e-10 39.5 18.7 0.0006 20.1 0.9 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35799.1 - 1.4e-08 34.9 22.6 0.0053 17.5 0.1 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK35799.1 - 1.2e-05 25.6 20.6 0.0052 17.1 0.6 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-Di19 PF05605.12 PIK35799.1 - 0.00092 19.5 5.5 0.00092 19.5 5.5 3.4 3 1 1 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK35799.1 - 0.0092 16.0 23.1 0.026 14.5 1.4 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK35799.1 - 0.12 13.0 11.5 5.4 7.7 5.5 3.9 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK35799.1 - 0.13 12.6 9.1 0.84 10.0 2.7 3.0 2 1 1 3 3 3 0 C2H2-type zinc ribbon DUF678 PF05077.12 PIK35799.1 - 0.78 9.9 8.8 6.8 6.9 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF678) zf-C2H2_9 PF16293.5 PIK35799.1 - 0.79 9.6 10.4 0.8 9.6 0.2 3.8 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 PIK35799.1 - 0.88 9.9 16.5 27 5.2 1.1 4.3 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 PIK35801.1 - 0.0013 19.4 24.0 0.078 13.8 1.2 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35801.1 - 0.0018 18.6 25.9 0.055 13.9 4.8 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK35801.1 - 0.0056 17.0 1.6 0.0056 17.0 1.6 2.0 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 PIK35801.1 - 0.1 13.0 0.2 0.1 13.0 0.2 3.8 4 0 0 4 4 4 0 Zinc-finger of C2H2 type SET PF00856.28 PIK35802.1 - 0.0015 19.0 0.0 0.0048 17.3 0.0 1.8 2 0 0 2 2 2 1 SET domain Hydrolase PF00702.26 PIK35804.1 - 0.001 19.4 0.0 0.0013 19.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK35804.1 - 0.0023 18.0 0.0 0.0057 16.7 0.0 1.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) MFS_1 PF07690.16 PIK35805.1 - 0.0001 21.4 16.3 0.0055 15.7 3.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RIC3 PF15361.6 PIK35806.1 - 0.0077 16.6 0.4 0.016 15.6 0.4 1.5 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 RT_RNaseH_2 PF17919.1 PIK35807.1 - 2.3e-35 120.6 0.0 4.2e-35 119.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35807.1 - 6.5e-32 110.0 0.0 1.5e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK35807.1 - 1.9e-19 69.5 0.7 5.2e-19 68.1 0.7 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK35807.1 - 0.00065 19.3 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAP_assoc PF03828.19 PIK35809.1 - 1.6e-06 28.2 0.0 3.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase AF-4 PF05110.13 PIK35810.1 - 4.2 5.3 8.7 3.6 5.5 8.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Biopterin_H PF00351.21 PIK35811.1 - 3.9e-172 571.8 0.1 5e-172 571.4 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 PIK35811.1 - 2.7e-07 30.2 0.0 5e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 ACT domain Glyco_hydro_38N PF01074.22 PIK35812.1 - 9.2e-63 212.3 2.0 4.7e-31 108.2 0.3 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 PIK35812.1 - 5.8e-34 118.0 0.1 4.1e-16 59.7 0.0 2.7 2 1 1 3 3 3 2 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 PIK35812.1 - 2.5e-22 78.8 0.0 5e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 PIK35812.1 - 5.3e-11 42.5 0.5 4.2e-10 39.6 0.0 2.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain zf-H2C2_2 PF13465.6 PIK35813.1 - 5.5e-85 276.3 96.9 1.1e-09 38.2 2.1 13.3 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.26 PIK35813.1 - 1.1e-43 145.3 86.0 2.8e-05 24.3 0.8 10.8 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK35813.1 - 1.4e-37 125.1 84.0 0.00026 21.6 0.7 11.1 12 0 0 12 12 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK35813.1 - 3e-27 94.3 61.6 6.4e-05 23.1 1.1 10.5 10 0 0 10 10 10 9 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK35813.1 - 4.8e-14 51.8 35.3 0.21 11.5 0.1 10.9 10 0 0 10 10 10 5 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 PIK35813.1 - 9.4e-14 51.0 72.9 0.013 15.4 1.0 10.8 10 0 0 10 10 10 6 C2H2-type zinc finger Imm-NTF2-2 PF15631.6 PIK35813.1 - 2e-09 37.6 0.0 1.7 9.0 0.0 7.4 3 2 4 7 7 7 2 NTF2 fold immunity protein PyrI_C PF02748.15 PIK35813.1 - 2.1e-09 37.1 59.6 0.51 10.3 0.5 10.8 9 2 2 11 11 11 9 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK35813.1 - 2.9e-08 33.3 39.3 0.45 10.3 0.2 10.1 10 0 0 10 10 10 4 zinc-finger C2H2-type zf-AN1 PF01428.16 PIK35813.1 - 3.4e-07 30.3 43.8 4.7 7.5 0.3 10.5 10 0 0 10 10 10 1 AN1-like Zinc finger GAGA PF09237.11 PIK35813.1 - 4.8e-06 26.3 8.8 0.32 10.8 0.0 5.8 2 2 4 7 7 7 2 GAGA factor Glyco_hydro_2_C PF02836.17 PIK35813.1 - 4.3e-05 22.8 21.9 0.05 12.7 1.0 5.1 1 1 4 5 5 5 4 Glycosyl hydrolases family 2, TIM barrel domain zf_UBZ PF18439.1 PIK35813.1 - 4.4e-05 23.0 33.0 11 5.7 0.1 10.2 10 0 0 10 10 10 0 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 PIK35813.1 - 4.5e-05 22.7 29.1 14 5.2 0.0 9.9 10 0 0 10 10 10 0 zinc-ribbon domain zf-U1 PF06220.12 PIK35813.1 - 9.5e-05 22.1 55.9 0.71 9.7 0.9 10.6 10 0 0 10 10 10 5 U1 zinc finger zf-Di19 PF05605.12 PIK35813.1 - 0.00015 22.0 57.3 0.61 10.4 1.6 8.7 4 1 8 12 12 12 7 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 PIK35813.1 - 0.00038 21.1 44.7 1.1 10.0 2.5 6.4 1 1 1 6 6 6 5 zinc-ribbon family C1_4 PF07975.12 PIK35813.1 - 0.00062 19.9 46.4 0.63 10.3 1.7 7.6 1 1 6 9 9 9 6 TFIIH C1-like domain XPA_N PF01286.18 PIK35813.1 - 0.014 15.4 23.9 49 4.1 0.1 9.5 10 0 0 10 10 10 0 XPA protein N-terminal zf-H2C2_5 PF13909.6 PIK35813.1 - 0.017 14.9 1.4 0.017 14.9 1.4 13.5 11 7 0 11 11 9 0 C2H2-type zinc-finger domain zf-met PF12874.7 PIK35813.1 - 0.054 13.9 75.9 0.59 10.6 1.9 10.7 10 0 0 10 10 10 0 Zinc-finger of C2H2 type Elf1 PF05129.13 PIK35813.1 - 0.064 13.3 37.8 0.19 11.8 1.6 6.2 2 1 4 6 6 6 0 Transcription elongation factor Elf1 like Yippee-Mis18 PF03226.14 PIK35813.1 - 0.46 10.7 33.7 6.1 7.1 3.6 6.2 3 3 1 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2HE PF16278.5 PIK35813.1 - 1.6 9.3 67.0 0.16 12.4 1.2 10.1 2 1 8 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Paramyx-P PF13008.7 PIK35813.1 - 2.6 7.6 30.5 7.9 6.0 1.6 6.3 3 2 6 9 9 9 0 Zinc-binding domain of Paramyxoviridae V protein zinc-ribbons_6 PF07191.12 PIK35813.1 - 3.1 7.8 49.1 18 5.4 2.7 9.6 1 1 7 8 8 8 0 zinc-ribbons HrpJ PF07201.11 PIK35814.1 - 0.059 13.7 0.1 0.06 13.7 0.1 1.0 1 0 0 1 1 1 0 HrpJ-like domain Carb_anhydrase PF00194.21 PIK35815.1 - 7.1e-46 156.8 0.2 8.2e-46 156.6 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF3402 PF11882.8 PIK35816.1 - 2.7 7.0 4.5 3.2 6.7 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) ARL2_Bind_BART PF11527.8 PIK35817.1 - 7.1e-33 113.2 10.3 7.1e-33 113.2 10.3 1.5 2 0 0 2 2 2 1 The ARF-like 2 binding protein BART Nic96 PF04097.14 PIK35818.1 - 9e-184 612.4 0.2 1.3e-183 611.8 0.0 1.3 2 0 0 2 2 2 1 Nup93/Nic96 ANAPC3 PF12895.7 PIK35818.1 - 0.12 12.7 1.5 0.26 11.5 0.2 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Elongin_A PF06881.11 PIK35818.1 - 0.64 10.6 4.5 2.8 8.5 0.1 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A MMS1_N PF10433.9 PIK35819.1 - 9.8e-92 308.1 0.0 1.5e-91 307.5 0.0 1.1 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CitMHS PF03600.16 PIK35821.1 - 8.1e-56 189.4 17.5 8.1e-56 189.4 17.5 1.9 1 1 1 2 2 2 1 Citrate transporter Na_sulph_symp PF00939.19 PIK35821.1 - 4.8e-20 72.1 31.5 1e-14 54.5 14.1 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.15 PIK35821.1 - 9.8e-17 61.4 18.1 2.8e-11 43.4 2.7 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein DUF2721 PF11026.8 PIK35821.1 - 0.039 13.8 0.1 0.039 13.8 0.1 5.3 6 1 1 7 7 7 0 Protein of unknown function (DUF2721) Mod_r PF07200.13 PIK35821.1 - 0.041 14.0 2.3 0.069 13.3 2.3 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Deltameth_res PF16020.5 PIK35821.1 - 0.43 10.5 6.8 1.7 8.6 0.1 3.7 2 1 1 3 3 3 0 Deltamethrin resistance Macoilin PF09726.9 PIK35822.1 - 1.6 7.2 15.5 2 6.9 15.5 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 PIK35822.1 - 8.8 5.0 10.7 13 4.4 10.7 1.3 1 0 0 1 1 1 0 Presenilin Cyclin_C PF02984.19 PIK35823.1 - 0.0087 16.1 0.5 0.018 15.1 0.5 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain CXCXC PF03128.14 PIK35824.1 - 1.9 9.1 0.1 1.9 9.1 0.1 6.4 7 0 0 7 7 7 0 CXCXC repeat MULE PF10551.9 PIK35826.1 - 5e-07 30.1 0.0 1.9e-06 28.2 0.0 2.1 1 0 0 1 1 1 1 MULE transposase domain GDP_Man_Dehyd PF16363.5 PIK35827.1 - 9.5e-57 192.9 0.1 2.5e-56 191.5 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK35827.1 - 2.6e-49 167.9 0.0 3.6e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 PIK35827.1 - 8.6e-10 38.2 0.0 9.1e-05 21.8 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 PIK35827.1 - 1.2e-09 37.5 0.0 1.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 PIK35827.1 - 2e-08 33.7 0.0 3.1e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 PIK35827.1 - 2.5e-07 30.1 0.4 0.0031 16.7 0.0 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 PIK35827.1 - 0.025 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Glyco_transf_4 PF13439.6 PIK35827.1 - 0.12 12.4 0.1 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Glyoxalase_3 PF13468.6 PIK35828.1 - 0.052 13.7 0.0 0.087 12.9 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain DUF1387 PF07139.11 PIK35830.1 - 3.2e-22 79.7 6.5 3.9e-22 79.4 6.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) Alpha-2-MRAP_C PF06401.11 PIK35830.1 - 0.035 14.1 6.1 0.051 13.5 6.1 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain ARA70 PF12489.8 PIK35830.1 - 0.043 14.0 3.1 0.052 13.7 2.6 1.4 1 1 0 1 1 1 0 Nuclear coactivator HisKA_3 PF07730.13 PIK35830.1 - 0.084 13.4 3.1 3.1 8.4 0.3 2.5 2 1 0 2 2 2 0 Histidine kinase LMBR1 PF04791.16 PIK35830.1 - 3.4 6.5 3.9 3.8 6.3 3.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CSN8_PSD8_EIF3K PF10075.9 PIK35832.1 - 2.5e-35 121.6 0.0 3.8e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 PIK35832.1 - 0.034 14.6 0.0 0.087 13.3 0.0 1.6 2 0 0 2 2 2 0 PCI domain IBR PF01485.21 PIK35833.1 - 1.7e-05 24.9 15.7 0.014 15.6 2.4 2.4 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain UIM PF02809.20 PIK35833.1 - 0.0019 18.0 14.7 0.092 12.7 1.8 3.6 3 0 0 3 3 3 2 Ubiquitin interaction motif zinc_ribbon_2 PF13240.6 PIK35833.1 - 0.046 13.5 3.1 4.9 7.0 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 PIK35833.1 - 0.16 12.1 1.4 20 5.4 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf_UBZ PF18439.1 PIK35833.1 - 1.1 9.0 6.8 10 5.8 0.5 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc-ribbons_6 PF07191.12 PIK35833.1 - 2.7 8.0 12.5 5 7.2 1.1 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-UDP PF14569.6 PIK35833.1 - 3.1 8.0 8.0 4.9 7.3 0.5 2.5 2 0 0 2 2 2 0 Zinc-binding RING-finger zf-ribbon_3 PF13248.6 PIK35833.1 - 3.8 7.1 9.1 7.6 6.1 1.4 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.16 PIK35833.1 - 3.9 7.6 11.1 3.3 7.8 1.4 2.7 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Laminin_EGF PF00053.24 PIK35834.1 - 2.2e-77 255.0 221.8 1.8e-09 37.6 16.5 15.1 14 1 1 15 15 15 12 Laminin EGF domain Laminin_B PF00052.18 PIK35834.1 - 2.4e-12 46.9 0.0 5e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_N PF00055.17 PIK35834.1 - 2.1e-10 40.6 0.0 2.1e-10 40.6 0.0 3.1 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) ROQ_II PF18386.1 PIK35835.1 - 1e-32 111.7 0.8 2.1e-32 110.7 0.8 1.6 1 0 0 1 1 1 1 Roquin II domain zf-RING_2 PF13639.6 PIK35835.1 - 8.4e-07 29.2 3.0 1.7e-06 28.2 3.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 PIK35835.1 - 6.4e-06 26.0 1.4 1.3e-05 25.0 1.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK35835.1 - 6.4e-06 26.1 4.3 1.7e-05 24.7 4.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-CCCH PF00642.24 PIK35835.1 - 0.00021 21.1 0.6 0.00043 20.1 0.6 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 PIK35835.1 - 0.00037 20.2 0.3 0.00075 19.2 0.3 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4 PF00097.25 PIK35835.1 - 0.00046 20.0 1.9 0.00099 18.9 1.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35835.1 - 0.00065 19.5 3.0 0.0015 18.4 3.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK35835.1 - 0.00082 19.5 5.1 0.0023 18.1 5.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK35835.1 - 0.0027 17.5 2.8 0.031 14.1 0.9 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf_CCCH_4 PF18345.1 PIK35835.1 - 0.0034 17.4 1.1 0.0069 16.4 1.1 1.6 1 0 0 1 1 1 1 Zinc finger domain Erythro_esteras PF05139.14 PIK35835.1 - 0.17 11.6 3.1 0.094 12.5 0.3 2.0 2 0 0 2 2 2 0 Erythromycin esterase Pro-kuma_activ PF09286.11 PIK35835.1 - 0.19 12.0 1.7 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain zf-RING_4 PF14570.6 PIK35835.1 - 1.3 8.9 4.2 2.8 7.8 4.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2H2_4 PF13894.6 PIK35836.1 - 9.6e-12 44.7 93.0 0.022 15.6 0.3 13.4 14 0 0 14 14 14 9 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK35836.1 - 7.7e-08 32.4 90.3 0.011 16.1 0.8 12.4 13 0 0 13 13 13 7 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 PIK35836.1 - 1.9e-07 30.7 3.4 1.9e-07 30.7 3.4 8.4 10 0 0 10 10 10 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 PIK35836.1 - 0.0038 17.5 28.0 0.08 13.2 0.5 5.6 5 1 0 5 5 5 3 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 PIK35836.1 - 0.0054 16.7 45.9 0.063 13.3 0.1 9.0 9 0 0 9 9 9 4 C2H2-type zinc finger zf-Di19 PF05605.12 PIK35836.1 - 0.04 14.2 0.5 0.04 14.2 0.5 9.3 6 1 4 10 10 10 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK35836.1 - 0.25 11.7 0.0 0.25 11.7 0.0 8.3 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK35836.1 - 1.1 9.6 53.3 1.4 9.3 0.0 10.4 5 4 4 10 10 10 0 C2H2 type zinc-finger (2 copies) SelP_N PF04592.14 PIK35837.1 - 0.011 15.1 7.5 0.015 14.7 7.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PGP_phosphatase PF09419.10 PIK35837.1 - 0.036 13.7 1.4 1.2 8.8 0.3 2.2 1 1 0 2 2 2 0 Mitochondrial PGP phosphatase Na_Ca_ex_C PF16494.5 PIK35837.1 - 0.17 12.3 2.3 0.28 11.6 2.3 1.4 1 1 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain Ribonucleas_3_3 PF14622.6 PIK35838.1 - 1.5e-33 115.7 0.1 1.2e-24 86.9 0.0 3.3 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 PIK35838.1 - 5.5e-25 88.0 0.1 3.4e-20 72.6 0.1 2.8 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.26 PIK35838.1 - 0.042 14.6 0.0 0.12 13.1 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif Hrs_helical PF12210.8 PIK35838.1 - 0.13 12.8 0.2 0.36 11.4 0.2 1.7 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate SRAP PF02586.14 PIK35839.1 - 2.6e-60 203.7 0.2 2.6e-60 203.7 0.2 1.6 2 0 0 2 2 2 1 SOS response associated peptidase (SRAP) HR1 PF02185.16 PIK35840.1 - 3.7e-11 43.0 6.3 3.7e-11 43.0 6.3 1.7 1 1 1 2 2 2 1 Hr1 repeat MscS_porin PF12795.7 PIK35840.1 - 0.0039 16.8 2.8 0.0044 16.6 2.8 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF4407 PF14362.6 PIK35840.1 - 0.0067 15.8 1.0 0.0081 15.5 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) FapA PF03961.13 PIK35840.1 - 0.038 12.6 2.5 0.041 12.5 2.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A HeLo PF14479.6 PIK35840.1 - 0.046 13.6 1.8 0.049 13.5 1.8 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation HrpB2 PF09487.10 PIK35840.1 - 0.056 13.9 0.6 0.092 13.2 0.6 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) GIT_CC PF16559.5 PIK35840.1 - 0.091 12.6 5.0 1.8 8.5 0.3 2.3 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uds1 PF15456.6 PIK35840.1 - 0.099 12.8 6.0 0.16 12.2 5.4 1.7 1 1 1 2 2 2 0 Up-regulated During Septation FemAB PF02388.16 PIK35840.1 - 0.12 11.3 5.0 0.14 11.0 5.0 1.0 1 0 0 1 1 1 0 FemAB family Exonuc_VII_L PF02601.15 PIK35840.1 - 0.14 11.7 4.0 0.16 11.6 4.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 PIK35840.1 - 0.28 11.4 7.6 0.47 10.7 7.5 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 PIK35840.1 - 0.52 10.6 3.3 2 8.8 3.2 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Flagellin_N PF00669.20 PIK35840.1 - 1.7 8.7 7.2 16 5.6 7.2 2.0 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region FERM_C PF09380.10 PIK35841.1 - 2.4e-24 85.5 0.3 4.7e-24 84.6 0.3 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PDZ PF00595.24 PIK35841.1 - 1.3e-15 57.5 0.0 2.9e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FA PF08736.11 PIK35841.1 - 2.6e-15 56.2 6.0 6.2e-15 55.0 6.0 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 PIK35841.1 - 4.4e-15 56.1 0.1 7.8e-15 55.3 0.1 1.4 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 PIK35841.1 - 1.6e-13 50.4 0.2 6.8e-13 48.4 0.1 2.1 2 0 0 2 2 2 1 FERM N-terminal domain PDZ_6 PF17820.1 PIK35841.1 - 0.0015 18.3 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK35841.1 - 0.02 15.2 0.0 0.52 10.7 0.0 2.3 2 0 0 2 2 2 0 PDZ domain Y_phosphatase PF00102.27 PIK35842.1 - 8.6e-78 261.1 0.9 9.9e-78 260.9 0.9 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK35842.1 - 0.00087 19.3 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 PIK35842.1 - 0.0066 16.3 0.1 0.015 15.1 0.1 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK35842.1 - 0.026 14.6 0.0 0.043 13.9 0.0 1.5 1 1 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 PIK35844.1 - 4.4e-25 87.5 34.6 1.4e-05 25.7 0.3 10.7 8 2 2 10 10 10 7 WD domain, G-beta repeat HELP PF03451.14 PIK35844.1 - 9.8e-24 83.0 0.2 1.7e-23 82.2 0.2 1.4 1 0 0 1 1 1 1 HELP motif ANAPC4_WD40 PF12894.7 PIK35844.1 - 8.8e-14 51.6 0.3 0.035 14.4 0.0 6.3 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK35844.1 - 0.014 14.3 0.3 0.76 8.7 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 PIK35844.1 - 0.056 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller SAM_1 PF00536.30 PIK35845.1 - 7e-15 55.2 0.1 3e-14 53.2 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK35845.1 - 3.1e-12 46.4 0.1 3.6e-11 43.0 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) GOLD_2 PF13897.6 PIK35846.1 - 2.5e-64 215.9 2.2 2.5e-64 215.9 2.2 2.5 3 0 0 3 3 3 1 Golgi-dynamics membrane-trafficking ACBP PF00887.19 PIK35846.1 - 2e-09 37.5 0.0 7.6e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 Acyl CoA binding protein U79_P34 PF03064.16 PIK35846.1 - 0.046 13.1 7.5 0.089 12.1 7.5 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MAP7 PF05672.11 PIK35846.1 - 0.12 12.1 33.9 0.29 10.8 33.9 1.6 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family TMEM247 PF15444.6 PIK35846.1 - 0.97 9.4 9.6 2.3 8.2 9.6 1.6 1 0 0 1 1 1 0 Transmembrane protein 247 FmdE PF02663.14 PIK35846.1 - 1.2 9.2 6.5 13 5.8 3.1 2.7 1 1 1 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon PIH1 PF08190.12 PIK35847.1 - 7.1e-58 194.7 1.8 2.1e-57 193.2 0.7 2.3 2 0 0 2 2 2 1 PIH1 N-terminal domain PIH1_CS PF18201.1 PIK35847.1 - 6e-28 97.2 0.0 3.7e-27 94.6 0.0 2.4 3 0 0 3 3 3 1 PIH1 CS-like domain MTS PF05175.14 PIK35849.1 - 0.06 12.9 0.2 0.21 11.1 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase small domain HATPase_c PF02518.26 PIK35850.1 - 7.3e-17 61.9 1.5 1.6e-07 31.8 0.1 2.2 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 PIK35850.1 - 1e-15 57.8 0.5 1.6e-07 31.3 0.1 2.2 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TMCCDC2 PF15844.5 PIK35850.1 - 0.035 14.0 0.0 11 5.9 0.0 2.8 1 1 2 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 PNP_UDP_1 PF01048.20 PIK35850.1 - 0.053 12.8 0.0 7.2 5.8 0.0 2.1 2 0 0 2 2 2 0 Phosphorylase superfamily YcbB PF08664.10 PIK35850.1 - 0.075 13.1 1.2 0.7 9.9 0.1 2.5 3 0 0 3 3 3 0 YcbB domain DUF3741 PF12552.8 PIK35850.1 - 2.1 8.4 5.3 1.2e+02 2.7 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3741) rve PF00665.26 PIK35851.1 - 1e-23 83.7 0.0 1.8e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK35851.1 - 2e-18 66.2 0.1 3.7e-18 65.4 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK35851.1 - 1.6e-05 24.6 0.2 4.3e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK35851.1 - 9e-05 22.6 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger dsrm PF00035.26 PIK35852.1 - 4.4e-31 107.4 0.0 4.1e-16 59.4 0.0 3.3 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK35852.1 - 1.2e-12 47.9 0.5 0.00019 21.6 0.0 4.3 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.5 PIK35852.1 - 1.4e-06 28.4 0.9 4.7e-05 23.5 0.1 2.6 2 1 1 3 3 3 1 Staufen C-terminal domain LPP20 PF02169.16 PIK35852.1 - 0.00063 20.0 1.5 0.007 16.7 0.3 2.5 2 0 0 2 2 2 1 LPP20 lipoprotein SH3BP5 PF05276.14 PIK35853.1 - 3e-52 177.7 33.8 3.9e-52 177.3 33.8 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) TbpB_B_D PF01298.18 PIK35853.1 - 0.0071 16.7 1.1 0.0071 16.7 1.1 1.9 2 0 0 2 2 2 1 C-lobe and N-lobe beta barrels of Tf-binding protein B DUF4856 PF16148.5 PIK35853.1 - 0.0078 15.3 3.9 0.0078 15.3 3.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4856) PIN_8 PF18476.1 PIK35853.1 - 0.83 9.5 22.0 0.046 13.6 12.7 2.4 1 1 1 2 2 2 0 PIN like domain Com_YlbF PF06133.11 PIK35853.1 - 1.2 9.8 29.0 0.25 12.0 4.0 3.7 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA ABC2_membrane_3 PF12698.7 PIK35854.1 - 8.8e-13 48.1 8.1 1.8e-12 47.0 8.1 1.5 1 0 0 1 1 1 1 ABC-2 family transporter protein GH3 PF03321.13 PIK35854.1 - 0.18 10.6 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 GH3 auxin-responsive promoter Novirhabdo_Nv PF05554.11 PIK35854.1 - 0.56 10.0 3.4 9.7 6.0 0.4 2.6 1 1 1 2 2 2 0 Viral hemorrhagic septicemia virus non-virion protein RhoGEF PF00621.20 PIK35856.1 - 0.032 14.5 1.3 0.21 11.8 0.1 2.8 3 1 0 3 3 3 0 RhoGEF domain Ub-Mut7C PF14451.6 PIK35856.1 - 0.045 13.6 0.4 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Mut7-C ubiquitin IL5 PF02025.15 PIK35856.1 - 0.048 14.0 0.1 0.16 12.3 0.1 1.9 1 0 0 1 1 1 0 Interleukin 5 Exo70 PF03081.15 PIK35856.1 - 0.075 12.1 3.7 0.27 10.2 0.1 2.9 3 1 0 3 3 3 0 Exo70 exocyst complex subunit Flu_M1_C PF08289.11 PIK35856.1 - 0.13 12.5 0.0 0.94 9.7 0.0 2.2 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain GrpE PF01025.19 PIK35856.1 - 0.15 11.7 0.3 6.1 6.5 0.0 2.6 2 0 0 2 2 2 0 GrpE 7tm_1 PF00001.21 PIK35857.1 - 2e-24 86.4 11.2 2.4e-24 86.1 11.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2852 PF11014.8 PIK35857.1 - 3.3 7.9 4.4 4.1 7.6 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) 7tm_1 PF00001.21 PIK35858.1 - 7.2e-28 97.6 14.1 3e-17 62.8 5.8 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK35858.1 - 0.025 14.0 17.1 0.11 11.9 4.6 2.4 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx Herpes_US9 PF06072.11 PIK35858.1 - 0.044 13.6 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Imm17 PF15562.6 PIK35858.1 - 0.091 12.6 0.1 0.091 12.6 0.1 2.0 2 1 0 2 2 2 0 Immunity protein 17 GET2 PF08690.10 PIK35858.1 - 0.3 10.7 1.1 0.51 10.0 1.1 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 EamA PF00892.20 PIK35859.1 - 3e-22 79.2 44.9 5.2e-17 62.3 15.0 2.0 2 0 0 2 2 2 2 EamA-like transporter family PTP_tm PF18861.1 PIK35859.1 - 1.8 8.5 6.6 0.12 12.4 0.7 2.0 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J HpcH_HpaI PF03328.14 PIK35860.1 - 2.4e-42 144.5 0.4 2.7e-42 144.4 0.4 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 PIK35860.1 - 0.0012 18.1 0.0 0.0015 17.8 0.0 1.1 1 0 0 1 1 1 1 C-C_Bond_Lyase of the TIM-Barrel fold BIR PF00653.21 PIK35862.1 - 2.8e-35 120.8 10.5 1e-22 80.5 4.6 2.2 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK35862.1 - 2.3e-07 30.9 5.6 0.00026 21.0 0.2 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like DUF562 PF04763.12 PIK35862.1 - 0.048 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF562) WD40 PF00400.32 PIK35865.1 - 4.2e-08 33.7 11.3 0.0092 16.8 0.3 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat mit_SMPDase PF14724.6 PIK35865.1 - 0.15 10.0 0.0 0.27 9.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase 7tm_1 PF00001.21 PIK35866.1 - 8.5e-41 140.0 11.3 1.1e-40 139.6 11.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35866.1 - 2.8e-09 37.0 13.8 4.3e-09 36.4 13.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK35866.1 - 4.7e-06 26.2 14.6 8.3e-06 25.4 14.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK35866.1 - 0.00039 20.2 4.5 0.00039 20.2 4.5 1.6 2 0 0 2 2 2 1 Olfactory receptor Ni_hydr_CYTB PF01292.20 PIK35866.1 - 0.77 9.3 10.3 0.12 11.9 0.3 2.7 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 NAD_binding_10 PF13460.6 PIK35867.1 - 4.9e-26 91.7 0.5 5.4e-26 91.6 0.5 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK35867.1 - 4.6e-11 42.7 0.3 5.1e-11 42.6 0.3 1.0 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK35867.1 - 8.5e-10 38.5 0.2 9.1e-10 38.4 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 PIK35867.1 - 2.3e-07 31.1 0.4 2.7e-07 30.8 0.4 1.2 1 0 0 1 1 1 1 TrkA-N domain Semialdhyde_dh PF01118.24 PIK35867.1 - 4.9e-06 27.0 0.2 6.1e-06 26.7 0.2 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 PIK35867.1 - 6.2e-06 26.4 0.3 7.6e-06 26.1 0.3 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GDP_Man_Dehyd PF16363.5 PIK35867.1 - 1.3e-05 24.8 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 PIK35867.1 - 1.4e-05 25.6 0.2 1.8e-05 25.2 0.2 1.3 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 PIK35867.1 - 8.3e-05 22.8 0.1 8.8e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3Beta_HSD PF01073.19 PIK35867.1 - 9.1e-05 21.6 0.1 0.0001 21.4 0.1 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 PIK35867.1 - 0.00023 20.4 0.1 0.00027 20.1 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 PIK35867.1 - 0.0014 18.9 0.2 0.0015 18.8 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DFP PF04127.15 PIK35867.1 - 0.0021 17.9 0.1 0.0024 17.7 0.1 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Shikimate_DH PF01488.20 PIK35867.1 - 0.0048 17.0 0.4 0.0052 16.8 0.4 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 PIK35867.1 - 0.0099 15.1 0.2 0.14 11.3 0.1 1.9 1 1 1 2 2 2 1 Male sterility protein adh_short PF00106.25 PIK35867.1 - 0.016 14.7 0.2 0.023 14.2 0.1 1.2 1 1 0 1 1 1 0 short chain dehydrogenase Rimk_N PF18030.1 PIK35867.1 - 0.039 14.3 0.0 0.047 14.1 0.0 1.2 1 0 0 1 1 1 0 RimK PreATP-grasp domain DNA_gyraseA_C PF03989.13 PIK35867.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller Mating_N PF12731.7 PIK35867.1 - 0.11 12.6 0.1 1 9.5 0.0 2.0 1 1 1 2 2 2 0 Mating-type protein beta 1 HEAT_2 PF13646.6 PIK35868.1 - 2.7e-17 63.0 2.5 5e-05 23.6 0.0 5.2 3 1 2 5 5 5 4 HEAT repeats HEAT PF02985.22 PIK35868.1 - 3.7e-10 39.2 10.4 0.68 10.4 0.0 7.9 8 0 0 8 8 8 4 HEAT repeat Cnd1 PF12717.7 PIK35868.1 - 6.9e-06 26.2 1.2 1 9.4 0.0 4.0 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK35868.1 - 0.0006 20.2 5.8 35 5.0 0.0 5.9 6 2 0 6 6 6 1 HEAT-like repeat RICTOR_V PF14668.6 PIK35868.1 - 0.076 13.3 0.0 2.5 8.4 0.0 2.9 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Ribosomal_L35p PF01632.19 PIK35869.1 - 9.7e-11 42.0 2.7 1.8e-10 41.2 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L35 RRM_1 PF00076.22 PIK35870.1 - 6.3e-11 41.9 0.0 4e-05 23.3 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK35870.1 - 0.007 16.0 0.1 0.65 9.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_SOX PF18371.1 PIK35870.1 - 0.087 13.2 0.7 5.6 7.4 0.1 2.5 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase FAP206 PF12018.8 PIK35871.1 - 5.9e-104 347.4 0.1 9.5e-104 346.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function YHS PF04945.13 PIK35871.1 - 0.012 15.6 0.0 0.029 14.5 0.0 1.6 1 0 0 1 1 1 0 YHS domain End3 PF12761.7 PIK35871.1 - 0.084 13.0 2.5 1.2 9.2 0.4 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF2475 PF10629.9 PIK35872.1 - 7.1e-16 58.2 16.7 7.4e-07 29.3 1.2 4.9 4 1 0 4 4 4 3 Protein of unknown function (DUF2475) adh_short_C2 PF13561.6 PIK35873.1 - 2.5e-09 37.0 0.1 3.2e-09 36.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK35873.1 - 1.3e-07 31.3 0.1 1.7e-07 30.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase UCR_TM PF02921.14 PIK35873.1 - 0.045 14.2 0.1 16 6.1 0.0 2.3 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region T3SS_NleG PF06416.12 PIK35873.1 - 0.19 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Effector protein NleG zf-MYND PF01753.18 PIK35874.1 - 7.9e-06 25.9 10.1 1.2e-05 25.3 10.1 1.2 1 0 0 1 1 1 1 MYND finger DUF997 PF06196.12 PIK35874.1 - 0.0012 18.8 0.8 0.0025 17.8 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF997) Tmemb_9 PF05434.11 PIK35874.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 TMEM9 Syndecan PF01034.20 PIK35874.1 - 7.1 6.6 8.6 15 5.6 8.6 1.4 1 0 0 1 1 1 0 Syndecan domain HAUS-augmin3 PF14932.6 PIK35877.1 - 0.031 13.9 5.1 0.039 13.5 5.1 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 PIK35877.1 - 0.064 12.1 3.4 0.069 12.0 3.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HhH-GPD PF00730.25 PIK35877.1 - 0.076 13.5 0.1 0.089 13.3 0.1 1.1 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein YabA PF06156.13 PIK35877.1 - 0.17 12.6 0.6 0.18 12.4 0.6 1.1 1 0 0 1 1 1 0 Initiation control protein YabA DUF2514 PF10721.9 PIK35877.1 - 0.2 11.7 11.4 0.25 11.4 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Laminin_EGF PF00053.24 PIK35878.1 - 7.4e-152 493.4 419.0 1.3e-10 41.2 10.7 23.0 20 2 3 23 23 23 21 Laminin EGF domain Laminin_N PF00055.17 PIK35878.1 - 2.7e-39 135.2 0.0 2.7e-39 135.2 0.0 4.3 5 0 0 5 5 5 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK35878.1 - 6.7e-31 107.0 0.0 1.1e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_I PF06008.14 PIK35878.1 - 1.1e-11 45.0 8.6 1.4e-11 44.6 8.6 1.1 1 0 0 1 1 1 1 Laminin Domain I Croc_4 PF17691.1 PIK35878.1 - 0.027 14.5 0.0 0.073 13.1 0.0 1.7 1 0 0 1 1 1 0 Contingent replication of cDNA 4 DUF2121 PF09894.9 PIK35878.1 - 0.2 11.1 0.6 0.37 10.3 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) 7tm_1 PF00001.21 PIK35879.1 - 4.5e-38 131.1 6.0 5.5e-38 130.8 6.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK35879.1 - 3.9e-13 49.4 6.1 1.1e-12 47.9 6.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK35879.1 - 0.0087 15.7 13.1 0.0087 15.7 13.1 2.5 3 1 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srab PF10292.9 PIK35879.1 - 0.09 11.7 7.5 0.12 11.3 0.4 3.0 3 0 0 3 3 3 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor DUF2852 PF11014.8 PIK35879.1 - 3.4 7.8 0.0 3.4 7.8 0.0 3.3 4 1 0 4 4 4 0 Protein of unknown function (DUF2852) Phage_integrase PF00589.22 PIK35880.1 - 0.032 14.0 0.8 0.061 13.1 0.0 1.9 2 0 0 2 2 2 0 Phage integrase family zf-C4 PF00105.18 PIK35882.1 - 2.7e-14 53.4 9.1 3.5e-14 53.0 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Lactamase_B_2 PF12706.7 PIK35883.1 - 1.7e-08 34.3 0.0 2.1e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF745 PF05335.13 PIK35884.1 - 0.15 11.8 0.8 0.19 11.4 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Lipase_GDSL_2 PF13472.6 PIK35885.1 - 9.8e-09 35.8 0.0 6.6e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK35885.1 - 9.9e-06 25.7 0.0 3.1e-05 24.0 0.0 1.8 1 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase PHD PF00628.29 PIK35885.1 - 8e-05 22.4 8.1 0.00014 21.7 8.1 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK35885.1 - 8.2e-05 22.1 3.3 0.00016 21.1 3.3 1.5 1 0 0 1 1 1 1 PHD-finger PHM7_cyt PF14703.6 PIK35885.1 - 0.017 15.4 0.2 0.15 12.3 0.2 2.5 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter OSK PF17182.4 PIK35885.1 - 0.027 13.7 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 OSK domain AAA_23 PF13476.6 PIK35885.1 - 0.48 10.9 5.4 26 5.3 6.9 2.2 1 1 1 2 2 2 0 AAA domain ABC_tran_CTD PF16326.5 PIK35885.1 - 0.63 10.3 5.4 15 5.9 4.0 2.9 3 0 0 3 3 3 0 ABC transporter C-terminal domain Snapin_Pallidin PF14712.6 PIK35885.1 - 0.68 10.4 5.0 17 5.9 2.5 2.8 2 1 0 2 2 2 0 Snapin/Pallidin FYVE_2 PF02318.16 PIK35885.1 - 3.9 7.7 7.3 0.28 11.4 1.6 2.1 2 0 0 2 2 2 0 FYVE-type zinc finger DUF4218 PF13960.6 PIK35886.1 - 0.0029 17.2 0.0 0.0056 16.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DUF935 PF06074.12 PIK35887.1 - 0.031 13.0 0.2 0.031 13.0 0.2 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF935) DUF3597 PF12200.8 PIK35887.1 - 0.15 12.6 1.1 0.24 12.0 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Neisseria_TspB PF05616.13 PIK35887.1 - 0.27 9.7 3.8 0.33 9.4 3.8 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein MID_MedPIWI PF18296.1 PIK35887.1 - 0.44 10.3 4.7 0.54 10.0 4.4 1.3 1 1 0 1 1 1 0 MID domain of medPIWI Trypan_PARP PF05887.11 PIK35887.1 - 1.7 8.6 6.0 3.1 7.8 6.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Fes1 PF08609.10 PIK35887.1 - 3.4 8.6 6.7 3.1 8.7 2.6 2.1 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 PHtD_u1 PF16645.5 PIK35887.1 - 4.6 7.7 15.7 1.1e+02 3.3 15.7 2.5 1 1 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein Peptidase_C78 PF07910.13 PIK35888.1 - 0.0048 16.4 0.0 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 MG2 PF01835.19 PIK35889.1 - 3.8e-16 59.3 0.0 1.1e-14 54.6 0.0 2.6 3 0 0 3 3 3 1 MG2 domain MG3 PF17791.1 PIK35889.1 - 4.6e-15 55.7 0.1 3.3e-14 52.9 0.0 2.4 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG1 PF17790.1 PIK35889.1 - 2e-08 34.5 0.3 5.3e-08 33.2 0.3 1.7 1 0 0 1 1 1 1 Macroglobulin domain MG1 MG4 PF17789.1 PIK35889.1 - 2.1e-08 34.2 0.1 2.6e-07 30.7 0.0 2.6 2 1 0 2 2 2 1 Macroglobulin domain MG4 RT_RNaseH_2 PF17919.1 PIK35890.1 - 1.5e-32 111.6 0.0 2.7e-32 110.8 0.0 1.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK35890.1 - 5.8e-20 71.5 0.0 1.1e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK35891.1 - 9.2e-06 26.1 0.0 1.9e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 PIK35891.1 - 2.3e-05 24.0 0.0 3.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK35891.1 - 0.0012 19.2 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK35891.1 - 0.0015 19.1 0.0 0.0037 17.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease TED_complement PF07678.14 PIK35892.1 - 1.1e-105 353.2 0.0 1.5e-105 352.7 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 PIK35892.1 - 1.6e-27 95.2 0.1 3.5e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 PIK35892.1 - 1.7e-18 67.1 1.2 3.1e-17 63.1 0.6 3.1 2 1 0 2 2 2 1 A-macroglobulin receptor binding domain NTR PF01759.21 PIK35892.1 - 4.2e-17 61.9 0.0 1.1e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_BRD PF07703.14 PIK35892.1 - 0.00021 21.6 1.6 0.0018 18.6 0.1 3.2 4 0 0 4 4 4 1 Alpha-2-macroglobulin bait region domain Prenyltrans PF00432.21 PIK35892.1 - 0.048 13.4 0.2 2 8.2 0.0 3.0 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat ANATO PF01821.18 PIK35892.1 - 4.2 8.3 6.2 0.79 10.6 1.1 2.6 2 1 0 2 2 2 0 Anaphylotoxin-like domain Ig_C17orf99 PF17736.1 PIK35893.1 - 0.0089 16.1 0.1 0.015 15.3 0.1 1.4 1 0 0 1 1 1 1 C17orf99 Ig domain zf-CCHC PF00098.23 PIK35894.1 - 3.2e-05 23.8 16.1 0.004 17.2 3.3 3.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35894.1 - 8e-05 22.4 6.3 0.0036 17.1 0.2 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35894.1 - 0.00027 20.6 14.2 0.6 9.9 1.1 4.0 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK35894.1 - 1.7 8.9 12.3 0.72 10.1 6.9 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK35894.1 - 9.7 6.0 12.9 1.1 9.0 0.3 4.0 4 0 0 4 4 4 0 C2H2 zinc-finger LRAT PF04970.13 PIK35895.1 - 1.3e-07 32.0 3.7 1.2e-06 28.8 3.7 2.3 1 1 0 1 1 1 1 Lecithin retinol acyltransferase DED PF01335.21 PIK35895.1 - 0.11 12.8 2.8 1 9.7 0.1 2.8 3 1 0 3 3 3 0 Death effector domain NLPC_P60 PF00877.19 PIK35895.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family Myosin_head PF00063.21 PIK35896.1 - 2.6e-155 518.4 4.3 2.6e-155 518.4 4.3 1.9 3 0 0 3 3 3 1 Myosin head (motor domain) PH PF00169.29 PIK35896.1 - 3.4e-28 98.2 10.6 1.3e-15 57.8 0.1 4.7 3 1 1 4 4 4 3 PH domain PH_8 PF15409.6 PIK35896.1 - 5.3e-09 36.2 9.8 6.2e-06 26.4 0.1 4.2 3 1 1 4 4 4 3 Pleckstrin homology domain PH_11 PF15413.6 PIK35896.1 - 8.5e-07 29.4 22.7 0.00022 21.6 2.2 6.0 2 2 1 4 4 4 2 Pleckstrin homology domain Mcp5_PH PF12814.7 PIK35896.1 - 1.4e-05 25.2 0.0 0.063 13.4 0.0 3.0 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology IQ PF00612.27 PIK35896.1 - 0.00032 20.2 14.0 0.22 11.4 0.3 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif BCL_N PF04714.13 PIK35896.1 - 0.0011 19.0 1.4 2.6 8.2 0.2 3.8 2 0 0 2 2 2 2 BCL7, N-terminal conserver region PH_9 PF15410.6 PIK35896.1 - 0.0015 18.8 0.1 0.041 14.3 0.0 3.6 1 1 1 2 2 2 1 Pleckstrin homology domain MyTH4 PF00784.17 PIK35897.1 - 6.3e-25 87.8 0.0 1.9e-24 86.3 0.0 1.9 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 PIK35897.1 - 2.9e-16 59.9 0.3 6.2e-16 58.9 0.3 1.5 1 0 0 1 1 1 1 FERM central domain RA PF00788.23 PIK35897.1 - 3.7e-05 24.3 0.0 0.0001 22.9 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain ACBP PF00887.19 PIK35897.1 - 0.018 15.2 0.2 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 Acyl CoA binding protein zf-RING_5 PF14634.6 PIK35898.1 - 1.2e-05 25.2 12.3 2.4e-05 24.2 12.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK35898.1 - 1.7e-05 24.6 12.0 3.2e-05 23.7 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35898.1 - 0.00018 21.4 9.9 0.00042 20.3 9.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK35898.1 - 0.0047 16.8 10.7 0.012 15.5 10.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Tup_N PF08581.10 PIK35898.1 - 0.0096 16.2 8.8 0.0096 16.2 8.8 2.4 3 0 0 3 3 3 1 Tup N-terminal zf-RING_2 PF13639.6 PIK35898.1 - 0.049 14.0 15.1 0.099 13.0 15.1 1.5 1 0 0 1 1 1 0 Ring finger domain DUF4140 PF13600.6 PIK35898.1 - 0.057 13.8 0.9 0.19 12.2 0.9 2.0 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Prok-RING_4 PF14447.6 PIK35898.1 - 0.14 12.0 11.3 0.32 10.9 11.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1272 PF06906.11 PIK35898.1 - 0.17 12.0 8.9 0.37 10.9 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) DUF3713 PF12506.8 PIK35898.1 - 0.93 9.8 5.4 1.2 9.5 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3713) zf-C3HC4_2 PF13923.6 PIK35898.1 - 0.94 9.4 14.3 2.1 8.3 14.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tho2 PF11262.8 PIK35898.1 - 3.1 6.9 10.2 0.29 10.3 3.3 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Dus PF01207.17 PIK35899.1 - 2e-24 86.3 0.0 1.1e-14 54.3 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 PIK35899.1 - 1.8e-06 27.7 10.2 4.3e-06 26.5 0.3 2.6 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 PIK35899.1 - 0.0039 16.9 0.7 0.0039 16.9 0.7 3.0 3 0 0 3 3 3 1 CCCH-type zinc finger Torus PF16131.5 PIK35899.1 - 0.01 16.5 2.3 0.01 16.5 0.5 2.0 1 1 1 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 PIK35899.1 - 0.38 10.9 8.9 0.11 12.6 0.9 2.8 2 1 1 3 3 3 0 Zinc finger domain LRR_4 PF12799.7 PIK35900.1 - 2.2e-06 27.9 6.5 0.016 15.6 0.3 2.9 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK35900.1 - 2.8e-05 23.8 8.4 0.35 11.0 0.2 5.1 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.6 PIK35900.1 - 0.0014 18.4 9.5 0.091 12.5 2.4 3.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 PIK35900.1 - 1.6 9.5 11.3 4.4 8.2 0.1 5.0 4 2 0 4 4 4 0 Leucine Rich Repeat Y_phosphatase PF00102.27 PIK35901.1 - 3.1e-111 370.6 0.1 3.4e-69 233.0 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Ig_3 PF13927.6 PIK35901.1 - 4.5e-18 65.6 0.1 2.7e-08 34.3 0.0 3.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK35901.1 - 6.8e-14 51.8 0.2 7.6e-06 26.0 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK35901.1 - 4.6e-13 49.1 0.0 3.5e-05 23.8 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK35901.1 - 1.6e-12 47.6 1.7 8.4e-05 22.8 0.0 3.5 4 0 0 4 4 3 2 Immunoglobulin domain V-set PF07686.17 PIK35901.1 - 5.4e-07 29.8 0.4 0.091 12.9 0.0 3.5 4 0 0 4 4 3 2 Immunoglobulin V-set domain fn3 PF00041.21 PIK35901.1 - 8.3e-06 26.1 5.0 0.34 11.3 0.1 4.6 4 1 0 4 4 4 2 Fibronectin type III domain PTPlike_phytase PF14566.6 PIK35901.1 - 0.004 17.3 0.0 0.013 15.6 0.0 1.9 1 0 0 1 1 1 1 Inositol hexakisphosphate Stevor PF17410.2 PIK35901.1 - 0.0043 16.6 0.6 0.011 15.3 0.6 1.6 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame C2-set_2 PF08205.12 PIK35901.1 - 0.0086 16.1 0.2 0.96 9.6 0.0 3.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DSPc PF00782.20 PIK35901.1 - 0.01 15.6 0.1 0.76 9.6 0.0 2.7 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Na_H_Exchanger PF00999.21 PIK35901.1 - 0.023 13.5 0.4 0.036 12.8 0.4 1.2 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family Peptidase_M1 PF01433.20 PIK35902.1 - 2.9e-66 223.1 1.4 9.9e-52 175.6 0.2 2.2 1 1 1 2 2 2 2 Peptidase family M1 domain Peptidase_M1_N PF17900.1 PIK35902.1 - 4.6e-48 163.9 0.0 7.5e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 PIK35902.1 - 0.00016 21.3 0.5 0.0003 20.4 0.5 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Aminopep PF10023.9 PIK35902.1 - 0.0061 16.0 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Putative aminopeptidase FAP206 PF12018.8 PIK35903.1 - 0.00024 20.7 0.1 0.00052 19.6 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function ADK PF00406.22 PIK35904.1 - 9e-29 100.5 5.2 5.1e-20 72.1 0.0 4.0 4 0 0 4 4 4 2 Adenylate kinase AAA_17 PF13207.6 PIK35904.1 - 1.8e-16 60.8 33.4 1e-11 45.4 0.0 6.6 5 2 3 8 8 6 4 AAA domain FAP206 PF12018.8 PIK35904.1 - 6.1e-07 29.2 0.1 6.1e-07 29.2 0.1 3.7 5 0 0 5 5 4 1 Domain of unknown function AAA_33 PF13671.6 PIK35904.1 - 2.1e-06 27.9 0.2 0.041 14.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 PIK35904.1 - 2.3e-05 24.9 4.4 0.078 13.4 0.0 3.4 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK35904.1 - 0.00013 22.0 0.6 0.19 11.7 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 PIK35904.1 - 0.00079 19.7 0.0 0.00079 19.7 0.0 4.9 5 1 0 5 5 5 1 AAA domain AAA_22 PF13401.6 PIK35904.1 - 0.0009 19.5 0.0 0.13 12.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain YHS PF04945.13 PIK35904.1 - 0.00093 19.2 0.4 0.0048 17.0 0.0 2.4 3 0 0 3 3 1 1 YHS domain AAA_24 PF13479.6 PIK35904.1 - 0.0061 16.3 0.0 0.14 11.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 PIK35904.1 - 0.0063 16.6 0.2 0.0063 16.6 0.2 3.3 4 0 0 4 4 1 1 Shikimate kinase RNA_helicase PF00910.22 PIK35904.1 - 0.012 16.0 0.0 2.3 8.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase TniB PF05621.11 PIK35904.1 - 0.022 14.2 0.0 0.1 12.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Roc PF08477.13 PIK35904.1 - 0.064 13.5 0.0 0.45 10.7 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 PIK35904.1 - 0.076 12.4 0.0 8.3 5.7 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 PIK35904.1 - 0.11 13.1 19.9 0.63 10.6 2.2 5.6 4 1 1 5 5 4 0 AAA domain NACHT PF05729.12 PIK35904.1 - 0.14 12.1 0.0 1.8 8.5 0.0 2.7 3 0 0 3 3 3 0 NACHT domain MMR_HSR1 PF01926.23 PIK35904.1 - 0.15 12.1 0.0 0.61 10.2 0.0 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK35904.1 - 0.19 12.1 7.0 8.7 6.7 0.0 4.0 4 0 0 4 4 4 0 AAA ATPase domain ABC_tran PF00005.27 PIK35904.1 - 2.3 8.7 0.0 2.3 8.7 0.0 4.0 4 1 0 4 4 3 0 ABC transporter Hydin_ADK PF17213.3 PIK35905.1 - 1.1e-06 29.1 0.3 2.1e-06 28.2 0.3 1.4 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain Cytidylate_kin PF02224.18 PIK35905.1 - 0.00022 21.0 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase AAA_17 PF13207.6 PIK35905.1 - 0.0011 19.4 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK35905.1 - 0.0022 18.4 0.0 0.0049 17.3 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 PIK35905.1 - 0.007 15.9 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 PIK35905.1 - 0.0089 16.2 0.1 0.027 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 PIK35905.1 - 0.041 14.4 0.1 0.1 13.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain SKI PF01202.22 PIK35905.1 - 0.06 13.5 0.4 0.26 11.4 0.0 2.2 1 1 1 2 2 2 0 Shikimate kinase FAP206 PF12018.8 PIK35905.1 - 0.079 12.4 2.7 0.26 10.8 0.1 2.8 2 2 0 2 2 2 0 Domain of unknown function ADK PF00406.22 PIK35905.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Adenylate kinase DNA_primase_lrg PF04104.14 PIK35905.1 - 0.22 10.9 1.9 0.37 10.1 1.9 1.4 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit CDC45 PF02724.14 PIK35905.1 - 6.4 4.9 8.4 8.3 4.6 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 PIK35905.1 - 7.7 6.7 7.4 13 5.9 7.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ADK PF00406.22 PIK35906.1 - 5.5e-17 62.3 0.0 7.9e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 PIK35906.1 - 1.1e-10 42.0 0.0 2.1e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK35906.1 - 0.00042 20.9 0.0 0.00095 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK35906.1 - 0.00061 19.7 0.1 0.001 19.0 0.1 1.3 1 0 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 PIK35906.1 - 0.013 14.7 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.12 PIK35906.1 - 0.016 14.5 0.1 0.091 12.0 0.1 1.9 1 1 1 2 2 2 0 Zeta toxin AAA PF00004.29 PIK35906.1 - 0.022 15.2 0.0 0.036 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Hydin_ADK PF17213.3 PIK35906.1 - 0.045 14.0 0.3 0.72 10.1 0.0 2.3 2 1 1 3 3 2 0 Hydin Adenylate kinase-like domain Herpes_Helicase PF02689.14 PIK35906.1 - 0.049 11.6 0.0 0.066 11.1 0.0 1.1 1 0 0 1 1 1 0 Helicase ABC_tran PF00005.27 PIK35906.1 - 0.056 14.0 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 PIK35906.1 - 0.057 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK35906.1 - 0.059 13.8 0.1 0.22 12.0 0.1 1.9 1 1 0 1 1 1 0 RNA helicase RXT2_N PF08595.11 PIK35906.1 - 0.065 13.3 1.2 0.14 12.2 1.2 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal AAA_33 PF13671.6 PIK35906.1 - 0.068 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK35906.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 PIK35906.1 - 0.086 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 PIK35906.1 - 0.11 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK35906.1 - 0.17 12.3 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Pox_Ag35 PF03286.14 PIK35906.1 - 0.31 10.8 2.2 0.48 10.2 2.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pkinase_Tyr PF07714.17 PIK35907.1 - 0.006 15.9 0.0 0.008 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NACHT PF05729.12 PIK35908.1 - 6.2e-12 45.8 0.1 1.1e-11 44.9 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK35908.1 - 0.00022 21.5 0.1 0.0057 16.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK35908.1 - 0.0009 19.7 0.0 0.0023 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK35908.1 - 0.0011 19.3 0.1 0.0022 18.4 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 PIK35908.1 - 0.0023 17.8 0.1 0.019 14.9 0.0 2.2 1 1 1 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 PIK35908.1 - 0.004 17.7 1.1 0.013 16.0 0.3 2.2 2 1 0 2 2 2 1 ABC transporter NB-ARC PF00931.22 PIK35908.1 - 0.0042 16.3 0.2 0.0042 16.3 0.2 2.0 2 0 0 2 2 2 1 NB-ARC domain TniB PF05621.11 PIK35908.1 - 0.011 15.2 0.1 0.021 14.3 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_5 PF07728.14 PIK35908.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK35908.1 - 0.025 14.1 0.1 0.15 11.6 0.1 2.2 1 1 0 1 1 1 0 P-loop containing dynein motor region pXO2-72 PF17443.2 PIK35908.1 - 0.049 13.9 0.0 0.2 11.9 0.0 2.1 1 0 0 1 1 1 0 Uncharacterized protein pXO2-72 DUF815 PF05673.13 PIK35908.1 - 0.056 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 PIK35908.1 - 0.099 13.0 0.3 0.79 10.1 0.0 2.8 3 0 0 3 3 3 0 RNA helicase NACHT PF05729.12 PIK35909.1 - 5.9e-10 39.3 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK35909.1 - 2.5e-06 28.0 0.0 4.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain V-set PF07686.17 PIK35909.1 - 2.2e-05 24.6 2.1 0.00012 22.2 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK35909.1 - 0.0001 22.6 1.6 0.0001 22.6 1.6 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain AAA PF00004.29 PIK35909.1 - 0.00077 19.9 0.0 0.0019 18.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF4929 PF16283.5 PIK35909.1 - 0.0037 16.3 0.0 0.0071 15.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4929) NB-ARC PF00931.22 PIK35909.1 - 0.0041 16.3 0.8 0.035 13.3 0.8 2.2 1 1 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 PIK35909.1 - 0.006 17.1 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter REJ PF02010.15 PIK35909.1 - 0.0083 15.0 1.2 0.0079 15.0 0.5 1.5 2 0 0 2 2 2 1 REJ domain DUF815 PF05673.13 PIK35909.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Marek_A PF02124.15 PIK35909.1 - 0.021 14.7 0.6 0.034 14.0 0.6 1.4 1 0 0 1 1 1 0 Marek's disease glycoprotein A C2-set_2 PF08205.12 PIK35909.1 - 0.024 14.7 0.6 0.06 13.4 0.6 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain AAA_7 PF12775.7 PIK35909.1 - 0.039 13.5 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 PIK35909.1 - 0.077 13.0 0.0 0.21 11.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ig PF00047.25 PIK35909.1 - 0.078 13.2 4.2 0.11 12.7 2.2 2.1 2 0 0 2 2 2 0 Immunoglobulin domain MMR_HSR1 PF01926.23 PIK35909.1 - 0.11 12.5 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase ApoO PF09769.9 PIK35909.1 - 0.12 12.3 0.1 3 7.8 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein O IstB_IS21 PF01695.17 PIK35909.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein V-set PF07686.17 PIK35911.1 - 7.1e-16 58.3 2.7 2.4e-07 30.9 0.5 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK35911.1 - 2.8e-09 37.5 0.7 0.004 17.7 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK35911.1 - 8.3e-07 29.0 1.0 0.01 15.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK35911.1 - 0.0011 19.3 0.2 2.8 8.4 0.0 3.1 3 2 0 3 3 3 2 Immunoglobulin domain SCIMP PF15050.6 PIK35911.1 - 0.0071 16.8 0.2 0.049 14.1 0.1 2.0 2 0 0 2 2 2 1 SCIMP protein EphA2_TM PF14575.6 PIK35911.1 - 0.014 16.3 0.1 0.066 14.1 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 PIK35911.1 - 0.019 15.2 0.9 0.03 14.6 0.1 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator ig PF00047.25 PIK35911.1 - 0.045 13.9 7.8 0.31 11.3 0.2 2.8 3 0 0 3 3 3 0 Immunoglobulin domain Cadherin_pro PF08758.11 PIK35911.1 - 0.073 13.3 0.2 8.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Cadherin prodomain like TMEM154 PF15102.6 PIK35911.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family SID-1_RNA_chan PF13965.6 PIK35911.1 - 0.083 11.3 0.4 0.3 9.4 0.1 1.8 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 DUF2897 PF11446.8 PIK35911.1 - 0.16 11.9 0.5 0.48 10.3 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Pkinase_Tyr PF07714.17 PIK35912.1 - 2.9e-12 46.4 0.0 4.5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK35912.1 - 0.0016 19.0 0.2 0.047 14.3 0.0 3.1 3 1 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK35912.1 - 0.064 13.3 0.1 0.28 11.3 0.0 2.0 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK35912.1 - 0.085 13.2 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 Immunoglobulin C1-set domain ig PF00047.25 PIK35912.1 - 0.11 12.7 1.2 0.34 11.1 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Death PF00531.22 PIK35917.1 - 4.9e-13 49.0 1.7 2.2e-11 43.8 0.8 2.2 2 0 0 2 2 2 2 Death domain FUN14 PF04930.15 PIK35918.1 - 1.1e-16 61.0 0.2 1.3e-16 60.7 0.2 1.1 1 0 0 1 1 1 1 FUN14 family RVT_N PF13655.6 PIK35918.1 - 0.0033 17.7 0.1 0.0047 17.2 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of reverse transcriptase Fe_dep_repr_C PF02742.15 PIK35918.1 - 0.19 11.8 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain Abhydrolase_3 PF07859.13 PIK35919.1 - 7.1e-48 163.2 0.0 1.4e-33 116.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK35919.1 - 2.4e-06 26.7 0.2 1.4e-05 24.2 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK35919.1 - 0.00069 19.1 0.1 0.0022 17.5 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 PIK35920.1 - 2.3e-33 115.9 0.0 3.2e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK35920.1 - 3.7e-06 26.1 0.0 4.8e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 PIK35920.1 - 2.1e-05 23.6 0.0 2.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 PIK35920.1 - 0.0059 16.1 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 PIK35920.1 - 0.2 10.3 0.0 0.63 8.7 0.0 1.7 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 PIK35921.1 - 2.7e-49 167.9 0.0 3.7e-32 111.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK35921.1 - 0.00036 19.5 0.0 0.0022 17.0 0.0 1.9 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK35921.1 - 0.00083 18.9 0.0 0.01 15.3 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK35921.1 - 0.18 10.6 0.1 0.46 9.3 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Lipoxygenase PF00305.19 PIK35922.1 - 1.6e-48 165.7 0.0 5.6e-47 160.6 0.0 2.1 1 1 1 2 2 2 2 Lipoxygenase PLAT PF01477.23 PIK35922.1 - 0.0022 18.6 0.0 0.0054 17.3 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain Urease_gamma PF00547.18 PIK35923.1 - 9.4e-16 58.0 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_1 PF01979.20 PIK35923.1 - 0.051 12.9 0.0 0.054 12.8 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family TfoX_N PF04993.13 PIK35924.1 - 0.17 12.1 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 TfoX N-terminal domain Neur_chan_memb PF02932.16 PIK35925.1 - 2.6e-20 73.5 2.6 3.5e-20 73.1 2.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK35925.1 - 4.4e-06 26.3 0.4 6.5e-06 25.7 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CNOT11 PF10155.9 PIK35925.1 - 0.022 14.9 0.1 0.041 14.0 0.1 1.4 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 Neur_chan_memb PF02932.16 PIK35926.1 - 5e-19 69.3 1.3 6.1e-19 69.0 1.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK35926.1 - 0.059 12.8 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 PIK35927.1 - 1.6e-29 102.9 1.1 1.8e-29 102.7 1.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK35927.1 - 2.7e-16 60.4 8.5 3.9e-16 59.8 8.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 PIK35928.1 - 1.8e-17 64.2 0.9 2.3e-17 63.8 0.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK35928.1 - 1.7e-12 47.2 0.1 2.4e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain TRP_N PF14558.6 PIK35928.1 - 0.049 14.0 0.1 0.082 13.3 0.1 1.3 1 0 0 1 1 1 0 ML-like domain Neur_chan_memb PF02932.16 PIK35929.1 - 2.1e-13 50.9 3.3 3.8e-13 50.1 3.3 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK35929.1 - 2.5e-09 36.9 0.0 3.3e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Mt_ATP-synt_B PF05405.14 PIK35930.1 - 1.9e-41 141.4 1.7 2.3e-41 141.1 1.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SWI-SNF_Ssr4 PF08549.10 PIK35930.1 - 0.057 12.1 1.9 0.067 11.8 1.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) MPS2 PF17060.5 PIK35930.1 - 0.081 12.2 3.4 0.11 11.8 3.4 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 2OG-FeII_Oxy_2 PF13532.6 PIK35931.1 - 8.3e-26 91.4 0.0 1.8e-25 90.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Rpn9_C PF18261.1 PIK35931.1 - 0.046 13.3 0.6 0.094 12.3 0.6 1.5 1 0 0 1 1 1 0 Rpn9 C-terminal helix DNA_pol_A_exo1 PF01612.20 PIK35932.1 - 3e-09 36.8 0.0 6.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease DUF5320 PF17253.2 PIK35932.1 - 0.071 14.2 11.7 0.23 12.5 11.7 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5320) LOH1CR12 PF10158.9 PIK35933.1 - 1.2e-39 135.3 0.8 1.6e-39 134.9 0.8 1.1 1 0 0 1 1 1 1 Tumour suppressor protein DUF1664 PF07889.12 PIK35933.1 - 0.005 16.9 1.1 0.008 16.2 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) ING PF12998.7 PIK35933.1 - 0.02 15.5 0.9 0.045 14.4 0.9 1.6 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding NPV_P10 PF05531.12 PIK35933.1 - 0.033 14.6 0.7 0.091 13.2 0.1 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein GrpE PF01025.19 PIK35933.1 - 0.05 13.3 0.1 0.079 12.6 0.1 1.3 1 0 0 1 1 1 0 GrpE LTXXQ PF07813.12 PIK35933.1 - 0.06 14.1 0.4 0.19 12.5 0.2 1.8 1 1 1 2 2 2 0 LTXXQ motif family protein BLOC1_2 PF10046.9 PIK35933.1 - 0.13 12.5 0.3 0.33 11.3 0.3 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MutS_III PF05192.18 PIK35933.1 - 0.32 11.2 2.0 0.89 9.7 2.1 1.6 1 1 0 1 1 1 0 MutS domain III DUF4732 PF15876.5 PIK35934.1 - 0.0019 18.3 0.0 0.003 17.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4732) DUF2203 PF09969.9 PIK35935.1 - 0.043 14.5 1.5 0.043 14.5 1.5 3.2 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) RAMPs PF03787.15 PIK35935.1 - 0.26 11.3 0.7 0.88 9.6 0.7 1.9 1 1 0 1 1 1 0 RAMP superfamily Lectin_N PF03954.14 PIK35935.1 - 1.6 8.5 15.5 0.41 10.4 0.3 3.5 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain DUF3552 PF12072.8 PIK35935.1 - 1.8 7.9 27.4 2.8 7.3 5.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) DUF948 PF06103.11 PIK35935.1 - 3.8 7.8 12.5 4.4 7.6 0.1 3.5 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3450 PF11932.8 PIK35935.1 - 7.1 5.9 27.0 1.8 7.8 7.6 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 PIK35935.1 - 7.4 5.7 18.4 0.081 12.2 2.2 2.9 3 0 0 3 3 3 0 TMPIT-like protein ATG16 PF08614.11 PIK35936.1 - 0.00055 20.2 58.6 0.0016 18.7 26.8 23.8 2 1 17 22 22 22 8 Autophagy protein 16 (ATG16) IFT57 PF10498.9 PIK35936.1 - 0.0032 16.5 10.5 0.0032 16.5 10.5 16.4 1 1 12 14 14 14 3 Intra-flagellar transport protein 57 COG5 PF10392.9 PIK35936.1 - 0.0046 17.1 8.1 0.0046 17.1 8.1 20.8 6 5 12 23 23 23 1 Golgi transport complex subunit 5 DUF641 PF04859.12 PIK35936.1 - 0.0065 16.8 6.8 0.0065 16.8 6.8 28.1 3 2 21 29 29 29 2 Plant protein of unknown function (DUF641) DUF3918 PF13056.6 PIK35937.1 - 0.053 13.2 1.0 0.074 12.7 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) 7tm_1 PF00001.21 PIK35938.1 - 3e-44 151.3 6.9 3.8e-44 151.0 6.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK35938.1 - 0.0016 18.1 5.4 0.0016 18.1 5.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK35938.1 - 1.7 8.3 18.9 0.49 10.1 12.4 2.8 2 1 0 2 2 2 0 Olfactory receptor V-set PF07686.17 PIK35939.1 - 0.00015 21.9 0.4 0.021 15.0 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin V-set domain I-set PF07679.16 PIK35940.1 - 1.6e-07 31.2 0.1 2.3e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35940.1 - 2.1e-06 28.2 0.3 2.8e-06 27.8 0.3 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK35940.1 - 6.7e-06 26.4 0.5 1.3e-05 25.5 0.5 1.4 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK35940.1 - 0.0036 17.5 1.4 0.0058 16.8 1.4 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK35941.1 - 2.4e-09 37.7 2.0 4.1e-05 24.1 0.3 2.9 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK35941.1 - 9.2e-06 25.9 1.8 0.0016 18.7 0.2 2.9 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK35941.1 - 2.1e-05 24.6 1.1 0.017 15.3 0.1 3.1 3 0 0 3 3 3 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK35941.1 - 0.0048 16.9 1.1 3.3 7.8 0.0 3.0 2 2 0 2 2 2 2 C17orf99 Ig domain I-set PF07679.16 PIK35941.1 - 0.038 14.0 0.0 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain C1-set PF07654.15 PIK35941.1 - 0.04 14.3 0.6 0.62 10.5 0.1 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain DND1_DSRM PF14709.7 PIK35941.1 - 0.083 13.2 0.2 3.8 7.9 0.0 2.7 2 1 1 3 3 3 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF4222 PF13973.6 PIK35941.1 - 0.1 12.2 0.0 34 4.1 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4222) Sulfotransfer_2 PF03567.14 PIK35942.1 - 3.7e-13 50.0 0.1 3.7e-13 50.0 0.1 1.9 2 0 0 2 2 2 1 Sulfotransferase family Ig_3 PF13927.6 PIK35942.1 - 3e-09 37.3 0.5 1.8e-05 25.2 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK35942.1 - 2e-08 34.4 0.3 1.2e-07 31.9 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK35942.1 - 5.4e-08 33.1 1.3 0.0057 17.0 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK35942.1 - 3.9e-06 26.8 0.2 0.00019 21.4 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Kinesin PF00225.23 PIK35942.1 - 1.1e-05 24.5 0.9 1.1e-05 24.5 0.9 1.8 2 0 0 2 2 2 1 Kinesin motor domain ig PF00047.25 PIK35942.1 - 2.6e-05 24.3 2.3 0.054 13.7 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain DUF4446 PF14584.6 PIK35942.1 - 0.0029 17.6 3.5 0.011 15.7 3.5 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) SIT PF15330.6 PIK35942.1 - 0.0032 17.9 1.4 0.0089 16.5 0.2 2.3 2 0 0 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT Microtub_bd PF16796.5 PIK35942.1 - 0.0036 17.2 1.8 0.0058 16.6 0.1 2.3 2 0 0 2 2 2 1 Microtubule binding C2-set_2 PF08205.12 PIK35942.1 - 0.023 14.8 0.1 0.073 13.1 0.1 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF4956 PF16316.5 PIK35942.1 - 0.03 14.0 0.2 0.073 12.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Marek_A PF02124.15 PIK35942.1 - 0.037 13.9 0.0 0.094 12.5 0.0 1.6 1 0 0 1 1 1 0 Marek's disease glycoprotein A DUF996 PF06195.13 PIK35942.1 - 0.065 13.5 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Izumo-Ig PF16706.5 PIK35942.1 - 0.084 12.9 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK35942.1 - 0.1 12.9 1.2 3.3 8.0 0.0 3.4 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_3 PF13927.6 PIK35943.1 - 3.2e-07 30.8 0.0 4.4e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK35943.1 - 9e-07 29.0 0.0 1.9e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK35943.1 - 8.8e-06 25.7 0.0 1.3e-05 25.2 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 PIK35943.1 - 0.0075 16.4 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK35943.1 - 0.0096 16.2 0.1 0.031 14.6 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Fibrinogen_C PF00147.18 PIK35944.1 - 4.9e-32 111.5 2.9 5.6e-32 111.3 2.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK35945.1 - 6.6e-44 150.3 5.0 8.2e-44 150.0 5.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain An_peroxidase PF03098.15 PIK35946.1 - 1.9e-186 620.7 0.0 1.1e-185 618.3 0.0 1.9 1 1 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 PIK35946.1 - 3.1e-79 261.1 0.0 3.6e-18 65.4 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK35946.1 - 1.3e-63 211.5 0.0 1.6e-15 57.4 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK35946.1 - 1.6e-44 149.9 0.0 1.9e-09 37.6 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK35946.1 - 2.4e-42 143.1 0.0 8.6e-09 35.6 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK35946.1 - 3.9e-18 65.6 6.3 0.033 14.3 0.1 8.3 5 4 1 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK35946.1 - 1.5e-17 63.4 0.0 0.0014 18.7 0.0 4.5 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK35946.1 - 8.4e-09 35.7 0.0 1.1 9.7 0.0 4.6 4 0 0 4 4 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Receptor_2B4 PF11465.8 PIK35946.1 - 7.8e-05 22.8 0.0 3 8.1 0.0 4.5 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Ig_4 PF16680.5 PIK35946.1 - 0.00028 21.1 0.0 2.8 8.3 0.0 4.4 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK35946.1 - 0.00068 19.2 0.0 0.72 9.5 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK35946.1 - 0.0036 17.3 0.0 7.5 6.7 0.0 4.1 4 0 0 4 4 4 1 C17orf99 Ig domain ATG16 PF08614.11 PIK35946.1 - 0.027 14.7 2.4 0.052 13.8 2.4 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) KxDL PF10241.9 PIK35946.1 - 0.064 13.5 0.8 0.2 12.0 0.8 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein Izumo-Ig PF16706.5 PIK35946.1 - 0.09 12.9 0.0 6.3 6.9 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Dor1 PF04124.12 PIK35946.1 - 0.33 9.6 2.8 0.52 8.9 2.8 1.2 1 0 0 1 1 1 0 Dor1-like family DUF1664 PF07889.12 PIK35946.1 - 1.8 8.6 5.3 3.7 7.6 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3425 PF11905.8 PIK35947.1 - 0.23 11.4 1.4 0.39 10.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3425) Chal_sti_synt_N PF00195.19 PIK35947.1 - 9.6 5.5 7.7 1.3 8.4 2.5 2.2 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain XK-related PF09815.9 PIK35948.1 - 3.6e-87 292.6 24.9 4.5e-87 292.3 24.9 1.1 1 0 0 1 1 1 1 XK-related protein Sugar_tr PF00083.24 PIK35949.1 - 6.3e-104 348.3 26.0 8.2e-76 255.7 17.8 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK35949.1 - 1.8e-31 109.4 33.4 7.6e-26 90.9 24.1 2.9 2 2 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 PIK35949.1 - 5.1e-05 21.9 4.9 5.1e-05 21.9 4.9 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 PIK35949.1 - 0.0027 16.2 5.7 0.22 9.9 1.4 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_4 PF06779.14 PIK35949.1 - 0.0063 15.9 12.3 0.0091 15.3 6.5 2.9 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB zf-CCHC PF00098.23 PIK35950.1 - 3.4e-07 30.0 15.8 0.00058 19.8 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK35950.1 - 0.00041 20.1 7.8 0.089 12.6 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35950.1 - 0.019 14.7 0.2 0.019 14.7 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK35950.1 - 0.02 14.6 0.8 0.02 14.6 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK35950.1 - 0.026 14.2 11.1 4.3 7.1 0.4 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK35950.1 - 0.028 14.4 15.9 0.21 11.6 1.2 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC PF00098.23 PIK35951.1 - 1.6e-07 31.1 15.8 0.00046 20.1 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK35951.1 - 0.0072 16.1 12.8 0.07 13.0 3.8 3.0 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK35951.1 - 0.012 15.3 11.1 3.5 7.4 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK35951.1 - 0.015 15.3 16.0 0.18 11.8 1.3 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK35951.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK35951.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger rve PF00665.26 PIK35953.1 - 0.00015 21.9 0.0 0.00032 20.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK35956.1 - 1.8e-21 76.7 0.0 2.7e-14 53.2 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 PIK35957.1 - 1.5e-20 72.7 0.1 5.8e-18 64.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.14 PIK35957.1 - 0.00047 18.6 8.4 0.00047 18.6 8.4 1.1 1 0 0 1 1 1 1 CDC45-like protein RRM_7 PF16367.5 PIK35957.1 - 0.0069 16.5 0.0 0.045 13.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif RR_TM4-6 PF06459.12 PIK35957.1 - 0.14 12.0 16.5 0.19 11.5 16.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 PIK35957.1 - 0.15 11.2 7.0 0.19 10.9 7.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mis14 PF08641.12 PIK35957.1 - 0.19 12.1 13.8 0.19 12.0 12.1 1.8 1 1 1 2 2 2 0 Kinetochore protein Mis14 like GAGA_bind PF06217.12 PIK35957.1 - 0.19 12.0 9.9 0.27 11.5 9.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family SAPS PF04499.15 PIK35957.1 - 0.28 9.9 6.8 0.31 9.8 6.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 PIK35957.1 - 0.31 9.8 12.0 0.4 9.4 12.0 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 PIK35957.1 - 0.32 9.1 21.6 0.41 8.8 21.6 1.0 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 PIK35957.1 - 0.81 9.4 20.3 1.2 8.8 20.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PDCD2_C PF04194.13 PIK35957.1 - 0.98 9.5 12.2 16 5.5 12.2 2.1 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain SLC12 PF03522.15 PIK35957.1 - 0.99 8.3 7.2 1.2 8.1 7.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 PIK35957.1 - 1.2 7.7 11.1 1.6 7.4 11.1 1.1 1 0 0 1 1 1 0 Raftlin MDM10 PF12519.8 PIK35957.1 - 2.6 6.8 8.2 3.3 6.5 8.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 PIK35957.1 - 3.1 7.8 5.3 4.3 7.3 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Merozoite_SPAM PF07133.11 PIK35957.1 - 4.2 7.3 26.2 6.3 6.8 26.2 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) adh_short PF00106.25 PIK35958.1 - 5.1e-20 71.8 0.0 1.5e-17 63.7 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK35958.1 - 1.3e-10 41.3 0.0 2.2e-08 34.0 0.0 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK35958.1 - 0.038 13.9 0.1 0.065 13.1 0.1 1.4 1 0 0 1 1 1 0 KR domain C2 PF00168.30 PIK35959.1 - 3.6e-29 101.1 0.1 8.9e-14 51.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain Miga PF10265.9 PIK35959.1 - 0.061 12.3 0.1 0.27 10.1 0.8 1.7 2 0 0 2 2 2 0 Mitoguardin Sulfotransfer_1 PF00685.27 PIK35960.1 - 2.3e-45 155.2 0.8 9.4e-44 149.9 0.8 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK35960.1 - 0.023 15.1 0.0 0.043 14.2 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family EF-hand_11 PF08976.11 PIK35961.1 - 7.5e-13 49.3 0.3 9.8e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 PIK35961.1 - 1.4e-08 35.1 0.1 0.0012 19.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK35961.1 - 1.3e-07 31.0 0.5 0.003 17.3 0.1 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 PIK35961.1 - 7.5e-07 28.3 0.0 0.027 14.0 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK35961.1 - 0.00014 21.6 0.0 0.0079 16.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK35961.1 - 0.00039 19.8 0.1 0.0063 16.0 0.0 2.5 2 0 0 2 2 2 1 EF hand Dockerin_1 PF00404.18 PIK35961.1 - 0.016 15.4 0.1 0.52 10.5 0.1 2.4 2 0 0 2 2 2 0 Dockerin type I domain RNA_pol_Rpb4 PF03874.16 PIK35961.1 - 0.22 11.9 1.8 0.36 11.2 1.1 1.9 1 1 1 2 2 2 0 RNA polymerase Rpb4 DUF5316 PF17247.2 PIK35962.1 - 0.0015 18.5 0.1 1.6 8.8 0.0 3.2 3 0 0 3 3 3 2 Family of unknown function (DUF5316) ZU5 PF00791.20 PIK35963.1 - 2e-14 53.7 0.0 4e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain 7tm_1 PF00001.21 PIK35964.1 - 3e-13 49.7 0.8 3e-13 49.7 0.8 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 PIK35964.1 - 0.052 13.0 6.7 0.072 12.6 6.7 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 PIK35964.1 - 0.27 10.8 8.3 0.71 9.4 8.3 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx ZU5 PF00791.20 PIK35965.1 - 8.3e-16 58.1 0.0 1.2e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 ZU5 domain RVT_1 PF00078.27 PIK35966.1 - 2.4e-07 30.5 0.0 5.9e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK35966.1 - 0.0032 18.0 0.5 0.009 16.6 0.5 1.9 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK35966.1 - 0.03 14.6 0.3 0.092 13.1 0.2 1.8 2 0 0 2 2 2 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK35966.1 - 0.034 14.8 0.4 0.088 13.5 0.3 1.8 1 1 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK35966.1 - 0.038 14.1 3.5 0.038 14.1 3.5 2.5 2 0 0 2 2 2 0 Zinc knuckle PolC_DP2 PF03833.13 PIK35966.1 - 3.1 5.5 11.3 4.7 4.9 11.3 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF2072 PF09845.9 PIK35966.1 - 3.3 8.0 8.6 6.3 7.1 8.6 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein Nucleic_acid_bd PF13820.6 PIK35968.1 - 3.1e-19 69.2 0.0 8.5e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Putative nucleic acid-binding region C2 PF00168.30 PIK35970.1 - 1.6e-22 79.7 0.0 3.3e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain NT-C2 PF10358.9 PIK35970.1 - 0.096 12.4 0.0 3.1 7.5 0.0 2.2 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins Ion_trans PF00520.31 PIK35971.1 - 3.8e-15 55.8 24.5 5e-15 55.4 24.5 1.2 1 0 0 1 1 1 1 Ion transport protein DNA_PPF PF02916.15 PIK35971.1 - 0.027 14.9 0.3 0.049 14.0 0.3 1.4 1 0 0 1 1 1 0 DNA polymerase processivity factor YebO PF13974.6 PIK35971.1 - 3.6 7.7 7.7 0.48 10.5 0.7 2.5 2 0 0 2 2 2 0 YebO-like protein TMEMspv1-c74-12 PF11044.8 PIK35972.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF4064 PF13273.6 PIK35972.1 - 0.057 13.7 0.2 0.093 13.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Syndecan PF01034.20 PIK35972.1 - 0.067 13.1 0.8 0.12 12.3 0.1 1.8 2 0 0 2 2 2 0 Syndecan domain SIT PF15330.6 PIK35972.1 - 0.14 12.6 0.0 0.36 11.3 0.0 1.8 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF2206 PF09971.9 PIK35972.1 - 0.21 10.3 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) GAPT PF11770.8 PIK35972.1 - 0.42 10.5 8.4 4.7 7.0 8.4 2.1 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) bZIP_1 PF00170.21 PIK35974.1 - 0.0057 16.7 4.4 0.0089 16.1 4.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK35974.1 - 0.025 14.6 5.4 0.044 13.9 5.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper NACHT PF05729.12 PIK35975.1 - 3.7e-08 33.5 0.0 8.1e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain DUF4723 PF15851.5 PIK35975.1 - 0.0067 16.5 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4723) ER PF01133.17 PIK35975.1 - 0.017 15.1 0.7 0.047 13.7 0.7 1.7 1 0 0 1 1 1 0 Enhancer of rudimentary NAD_binding_5 PF07994.12 PIK35975.1 - 0.023 14.1 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase AAA_25 PF13481.6 PIK35975.1 - 0.033 13.8 0.0 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-C3HC4 PF00097.25 PIK35976.1 - 1.5e-09 37.6 8.9 1.5e-09 37.6 8.9 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK35976.1 - 4.3e-09 36.2 7.7 4.3e-09 36.2 7.7 2.9 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK35976.1 - 3.4e-07 30.0 6.9 3.4e-07 30.0 6.9 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35976.1 - 4.5e-06 26.4 9.0 4.5e-06 26.4 9.0 3.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK35976.1 - 1e-05 25.7 7.2 1e-05 25.7 7.2 3.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK35976.1 - 2.7e-05 24.0 7.4 2.7e-05 24.0 7.4 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK35976.1 - 0.00014 21.9 9.4 0.00014 21.9 9.4 3.6 3 2 1 4 4 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK35976.1 - 0.0002 21.5 26.5 0.0012 18.9 12.7 4.0 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK35976.1 - 0.00066 19.5 7.0 0.00066 19.5 7.0 3.4 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 ArAE_2 PF10334.9 PIK35976.1 - 0.0025 17.7 0.0 0.0092 15.8 0.0 1.8 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 zf-ANAPC11 PF12861.7 PIK35976.1 - 0.036 14.1 1.4 0.036 14.1 1.4 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 11 RING-H2 finger Noelin-1 PF12308.8 PIK35976.1 - 2.2 8.3 7.2 2.3 8.3 0.5 2.9 2 0 0 2 2 2 0 Neurogenesis glycoprotein DUF883 PF05957.13 PIK35976.1 - 3.7 8.2 5.0 29 5.3 2.9 2.8 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.12 PIK35976.1 - 3.9 7.5 6.8 0.43 10.6 0.7 2.4 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-RING_UBOX PF13445.6 PIK35978.1 - 9.7e-09 35.1 6.0 9.7e-09 35.1 6.0 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK35978.1 - 1e-08 34.9 9.0 1e-08 34.9 9.0 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK35978.1 - 2.8e-06 27.1 9.1 2.8e-06 27.1 9.1 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK35978.1 - 1.8e-05 25.0 7.7 1.8e-05 25.0 7.7 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK35978.1 - 2.7e-05 23.9 9.9 2.7e-05 23.9 9.9 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK35978.1 - 3.1e-05 24.0 9.5 3.1e-05 24.0 9.5 3.6 3 2 2 5 5 5 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK35978.1 - 0.00037 20.4 7.3 0.00037 20.4 7.3 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK35978.1 - 0.00095 19.3 27.6 0.0021 18.2 12.5 3.8 5 0 0 5 5 5 2 B-box zinc finger Acetyltransf_4 PF13420.7 PIK35978.1 - 0.035 14.3 2.6 0.078 13.1 2.6 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain AcylCoA_dehyd_C PF12186.8 PIK35978.1 - 3 8.0 7.6 7.6 6.7 0.7 3.3 2 1 1 3 3 3 0 Acyl-CoA dehydrogenase C terminal Glyco_transf_10 PF00852.19 PIK35979.1 - 5.4e-58 195.6 3.2 8e-58 195.1 3.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK35979.1 - 3.7e-15 56.3 1.5 8.5e-15 55.2 1.5 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Ogr_Delta PF04606.12 PIK35979.1 - 0.12 12.3 1.9 1.9 8.5 0.4 2.7 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger LIDHydrolase PF10230.9 PIK35980.1 - 1.7e-46 158.9 0.0 2e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 PIK35980.1 - 0.00024 20.4 0.0 0.0003 20.1 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK35980.1 - 0.0014 19.3 0.0 0.0019 18.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 PIK35980.1 - 0.015 15.1 0.0 0.057 13.3 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase Peptidase_S9 PF00326.21 PIK35980.1 - 0.055 12.9 0.0 0.084 12.3 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 PIK35980.1 - 0.065 12.9 0.0 0.12 12.0 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 PIK35980.1 - 0.17 10.8 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme LCAT PF02450.15 PIK35980.1 - 0.23 10.6 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Cullin PF00888.22 PIK35981.1 - 1.6e-66 225.2 8.7 2.5e-55 188.3 1.1 2.0 2 0 0 2 2 2 2 Cullin family Cullin PF00888.22 PIK35982.1 - 1.5e-47 162.6 0.1 1.8e-47 162.3 0.1 1.1 1 0 0 1 1 1 1 Cullin family fn3 PF00041.21 PIK35983.1 - 5.7e-26 90.7 5.5 5.2e-09 36.3 0.1 4.4 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK35983.1 - 0.0031 18.1 0.0 0.15 12.7 0.0 3.3 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain RB_A PF01858.17 PIK35984.1 - 1.9e-48 164.9 0.6 2.3e-48 164.7 0.6 1.1 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 PIK35985.1 - 0.0024 17.9 0.2 0.0062 16.6 0.0 1.7 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain FinO_N PF12602.8 PIK35985.1 - 0.0057 16.9 0.1 0.011 16.0 0.1 1.4 1 0 0 1 1 1 1 Fertility inhibition protein N terminal KIAA1430 PF13879.6 PIK35986.1 - 1.2e-26 93.4 8.6 1.2e-26 93.4 8.6 2.6 2 1 0 2 2 2 1 KIAA1430 homologue FancD2 PF14631.6 PIK35986.1 - 0.57 7.5 12.1 0.79 7.0 12.1 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF4707 PF15806.5 PIK35987.1 - 2.5e-14 53.1 5.9 3e-14 52.8 1.6 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4707) Retrotran_gag_2 PF14223.6 PIK35988.1 - 2.8e-06 27.0 3.9 2.9e-06 27.0 2.2 2.0 1 1 0 1 1 1 1 gag-polypeptide of LTR copia-type TetR_C_37 PF18665.1 PIK35988.1 - 0.023 15.3 4.9 0.77 10.4 2.6 2.9 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Ets PF00178.22 PIK35988.1 - 0.029 14.8 4.2 1.8 9.1 0.1 2.8 3 0 0 3 3 3 0 Ets-domain RVT_3 PF13456.6 PIK35989.1 - 0.0002 21.1 0.5 0.0011 18.7 0.5 1.9 1 1 0 1 1 1 1 Reverse transcriptase-like DUF2119 PF09892.9 PIK35989.1 - 0.068 12.5 0.4 0.094 12.1 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) BON PF04972.17 PIK35989.1 - 0.45 10.9 1.7 13 6.2 0.1 2.7 3 0 0 3 3 3 0 BON domain BTB PF00651.31 PIK35990.1 - 5.5e-40 136.1 7.1 6.7e-20 71.4 0.2 3.3 2 1 1 3 3 3 3 BTB/POZ domain Ank_2 PF12796.7 PIK35990.1 - 1.6e-06 28.6 0.0 6e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK35990.1 - 7.3e-06 26.2 0.0 2.1e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK35990.1 - 8.3e-06 26.0 0.0 0.0004 20.7 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 PIK35990.1 - 3.2e-05 24.0 0.8 0.00047 20.4 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 PIK35990.1 - 4.1e-05 24.0 0.0 0.00017 22.1 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) BACK PF07707.15 PIK35990.1 - 0.0092 16.1 2.5 0.02 14.9 0.2 2.7 4 0 0 4 4 4 1 BTB And C-terminal Kelch BTB_3 PF16017.5 PIK35990.1 - 0.037 14.1 0.4 1.5 8.9 0.1 2.6 2 0 0 2 2 2 0 BTB/POZ domain DUF3342 PF11822.8 PIK35990.1 - 0.094 12.9 2.2 0.93 9.7 0.3 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) BTB_2 PF02214.22 PIK35990.1 - 0.33 11.3 2.6 44 4.5 1.7 3.6 2 1 0 2 2 2 0 BTB/POZ domain Sod_Cu PF00080.20 PIK35991.1 - 2.1e-35 121.9 0.4 2.6e-35 121.7 0.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) ZU5 PF00791.20 PIK35992.1 - 7.4e-24 83.9 0.5 5.8e-12 45.8 0.1 2.8 2 0 0 2 2 2 2 ZU5 domain DUF1664 PF07889.12 PIK35992.1 - 1.9 8.5 16.8 0.51 10.4 7.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 PIK35992.1 - 2.4 7.2 20.8 5.7 5.9 20.8 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 PIK35992.1 - 5.7 6.2 14.6 12 5.2 14.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Filamin PF00630.19 PIK35993.1 - 0.0088 16.9 0.0 0.09 13.6 0.0 2.3 1 1 0 1 1 1 1 Filamin/ABP280 repeat 7tm_1 PF00001.21 PIK35994.1 - 1.4e-31 109.8 11.1 1.6e-31 109.6 11.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK35994.1 - 6.5e-05 22.8 5.7 8e-05 22.5 5.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK35994.1 - 0.0061 16.2 13.0 0.0087 15.7 13.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx RseC_MucC PF04246.12 PIK35994.1 - 0.031 14.2 0.1 0.031 14.2 0.1 2.5 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC EMP70 PF02990.16 PIK35994.1 - 1.2 7.7 13.1 1.3 7.6 12.5 1.3 1 1 0 1 1 1 0 Endomembrane protein 70 AP1AR PF15745.5 PIK35995.1 - 1.5e-13 51.1 16.9 3.2e-13 49.9 7.5 3.1 1 1 2 3 3 3 2 AP-1 complex-associated regulatory protein GDYXXLXY PF14345.6 PIK35995.1 - 0.13 12.0 0.1 0.28 11.0 0.1 1.6 1 1 0 1 1 1 0 GDYXXLXY protein CK1gamma_C PF12605.8 PIK35995.1 - 0.32 12.2 5.8 0.93 10.7 0.8 2.2 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal DUF4586 PF15239.6 PIK35996.1 - 1.3e-106 357.2 18.1 1.5e-106 357.0 18.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Aminotran_3 PF00202.21 PIK35997.1 - 6.6e-74 249.0 0.0 8e-74 248.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III RcsC PF09456.10 PIK35997.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) THF_DHG_CYH_C PF02882.19 PIK35998.1 - 1.3e-64 216.4 0.6 1.7e-64 215.9 0.6 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 PIK35998.1 - 9.4e-38 129.1 0.9 1.4e-37 128.5 0.9 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CbiJ PF02571.14 PIK35998.1 - 0.04 13.4 0.1 0.085 12.3 0.1 1.5 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK Shikimate_DH PF01488.20 PIK35998.1 - 0.075 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MULE PF10551.9 PIK36000.1 - 2.2e-08 34.4 0.4 6.9e-08 32.8 0.0 2.0 3 0 0 3 3 3 1 MULE transposase domain DUF5575 PF17738.1 PIK36000.1 - 0.0021 17.1 0.0 0.0033 16.5 0.0 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF5575) Peptidase_S7 PF00949.21 PIK36000.1 - 0.19 11.6 0.7 2.2 8.1 0.7 2.0 1 1 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Pkinase PF00069.25 PIK36001.1 - 1.9e-46 158.6 0.7 2.4e-46 158.3 0.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36001.1 - 4.7e-26 91.6 0.2 5.7e-26 91.3 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK36001.1 - 6.8e-05 22.0 0.6 0.00023 20.2 0.6 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK36001.1 - 0.0007 18.7 0.2 0.0011 18.1 0.2 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 PIK36001.1 - 0.037 13.4 2.7 0.09 12.1 1.1 2.3 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF866 PF05907.13 PIK36001.1 - 0.1 12.5 0.5 0.39 10.6 0.1 1.9 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) APH PF01636.23 PIK36001.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 PIK36002.1 - 9.7e-16 57.9 0.0 1e-15 57.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36002.1 - 0.0042 16.4 0.0 0.0045 16.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36003.1 - 0.071 12.5 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Peptidase_M8 PF01457.16 PIK36004.1 - 1.1e-39 136.6 6.6 3.5e-34 118.4 0.9 2.5 1 1 1 2 2 2 2 Leishmanolysin Erg28 PF03694.13 PIK36005.1 - 2.6e-35 121.1 2.9 3.3e-35 120.8 2.9 1.1 1 0 0 1 1 1 1 Erg28 like protein TraQ PF09679.10 PIK36005.1 - 0.011 15.6 0.1 0.12 12.3 0.0 2.1 1 1 1 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Peptidase_M14 PF00246.24 PIK36006.1 - 6.4e-75 252.6 0.1 7.6e-75 252.4 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK36006.1 - 3.8e-09 36.8 0.1 1.1e-08 35.3 0.1 1.9 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Propep_M14 PF02244.16 PIK36007.1 - 6.5e-16 58.5 0.0 7.6e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Carboxypeptidase activation peptide NHL PF01436.21 PIK36008.1 - 0.00017 21.4 0.0 0.068 13.2 0.0 4.1 5 0 0 5 5 5 1 NHL repeat SdiA-regulated PF06977.11 PIK36008.1 - 0.0013 18.0 0.1 0.0052 16.1 0.0 1.9 2 1 1 3 3 3 1 SdiA-regulated Ldl_recept_b PF00058.17 PIK36009.1 - 9.6e-17 61.2 2.7 2.5e-10 40.7 0.2 3.4 3 0 0 3 3 3 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK36009.1 - 0.038 13.6 0.3 0.13 11.8 0.1 1.9 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_a PF00057.18 PIK36010.1 - 1.6e-42 143.4 74.5 1e-12 48.0 12.9 4.6 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK36010.1 - 6.7e-05 22.7 0.9 6.7e-05 22.7 0.9 5.6 6 0 0 6 6 6 1 Complement Clr-like EGF-like PRKCSH-like PF12999.7 PIK36010.1 - 0.19 11.5 50.4 0.72 9.6 22.1 3.2 1 1 2 3 3 3 0 Glucosidase II beta subunit-like GATA-N PF05349.12 PIK36011.1 - 2.3e-07 31.3 18.2 2.3e-07 31.3 18.2 2.1 1 1 1 2 2 2 1 GATA-type transcription activator, N-terminal GATA PF00320.27 PIK36012.1 - 9.1e-16 57.2 5.1 1.6e-15 56.4 5.1 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 PIK36012.1 - 0.0093 15.5 1.3 0.015 14.8 1.3 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1387 PF07139.11 PIK36012.1 - 3.7 7.2 11.7 5.3 6.7 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4050 PF13259.6 PIK36012.1 - 7.8 6.8 13.8 3.7 7.8 11.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) DNA_pol_A_exo1 PF01612.20 PIK36013.1 - 5.8e-19 68.5 0.0 1.1e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S14 PF00253.21 PIK36013.1 - 0.0076 16.0 0.5 0.031 14.0 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e SAP30_Sin3_bdg PF13867.6 PIK36013.1 - 0.075 13.4 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF2826 PF11442.8 PIK36013.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) Fer4_17 PF13534.6 PIK36013.1 - 1.8 9.2 4.7 0.62 10.6 0.8 2.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain RFC1 PF08519.12 PIK36014.1 - 1.1e-57 194.5 0.0 2.7e-57 193.3 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 PIK36014.1 - 1.5e-15 57.8 0.0 5.3e-15 56.0 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 PIK36014.1 - 8.2e-11 42.1 0.1 4e-10 39.9 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 PIK36014.1 - 1.2e-07 31.8 0.0 1.3e-06 28.5 0.1 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain PTCB-BRCT PF12738.7 PIK36014.1 - 0.00038 20.4 0.0 0.0012 18.8 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.12 PIK36014.1 - 0.00059 19.6 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 PIK36014.1 - 0.00095 19.7 0.3 0.0057 17.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK36014.1 - 0.0011 19.3 0.1 0.021 15.2 0.0 3.1 2 1 0 2 2 2 1 RNA helicase AAA_17 PF13207.6 PIK36014.1 - 0.0022 18.4 0.3 0.022 15.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK36014.1 - 0.0036 16.8 0.1 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 PIK36014.1 - 0.0039 17.2 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK36014.1 - 0.005 17.1 0.1 0.029 14.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK36014.1 - 0.0051 16.8 0.1 0.028 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK36014.1 - 0.011 16.1 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 PIK36014.1 - 0.023 14.9 0.0 0.071 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK36014.1 - 0.037 13.7 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 PIK36014.1 - 0.13 12.6 0.0 4.9 7.6 0.0 3.0 3 0 0 3 3 2 0 AAA C-terminal domain NTPase_1 PF03266.15 PIK36014.1 - 1.1 9.2 3.8 0.54 10.1 0.2 2.3 2 1 1 3 3 3 0 NTPase Ribosomal_L19e PF01280.20 PIK36015.1 - 4.5e-65 218.1 12.5 4.5e-65 218.1 12.5 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e RVT_1 PF00078.27 PIK36016.1 - 1.6e-19 70.3 0.0 2e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ZU5 PF00791.20 PIK36017.1 - 2.3e-13 50.3 0.0 9.2e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 ZU5 domain DUF2540 PF10802.8 PIK36017.1 - 0.9 9.7 4.9 5.1 7.3 1.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2540) Cauli_AT PF03233.13 PIK36018.1 - 0.022 14.7 2.0 0.022 14.7 2.0 2.4 1 1 1 2 2 2 0 Aphid transmission protein Diphthamide_syn PF01866.17 PIK36018.1 - 0.031 13.7 4.5 0.041 13.3 4.5 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein PAS_7 PF12860.7 PIK36018.1 - 0.047 13.8 2.9 0.099 12.8 0.1 2.5 1 1 1 2 2 2 0 PAS fold Sulfotransfer_2 PF03567.14 PIK36018.1 - 0.099 12.5 3.9 0.17 11.7 3.9 1.4 1 0 0 1 1 1 0 Sulfotransferase family Spc7 PF08317.11 PIK36018.1 - 0.13 11.2 36.9 0.035 13.0 29.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 PIK36018.1 - 0.13 11.6 36.0 0.095 12.0 21.4 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 PIK36018.1 - 0.3 8.5 26.7 0.4 8.2 26.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.9 PIK36018.1 - 0.34 10.0 20.5 0.52 9.3 20.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Peptidase_S46 PF10459.9 PIK36018.1 - 0.76 8.3 13.8 1.1 7.8 13.8 1.2 1 0 0 1 1 1 0 Peptidase S46 ERM PF00769.19 PIK36018.1 - 0.82 9.4 45.9 1.8 8.3 45.9 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 PIK36018.1 - 1.8 8.6 15.1 0.47 10.5 5.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1542 PF07564.11 PIK36018.1 - 3.7 7.7 24.4 1.6 8.9 2.0 4.5 1 1 2 4 4 4 0 Domain of Unknown Function (DUF1542) Sipho_Gp157 PF05565.11 PIK36018.1 - 4.1 7.4 24.3 15 5.5 4.1 2.9 1 1 1 2 2 2 0 Siphovirus Gp157 RNase_E_G PF10150.9 PIK36018.1 - 4.7 6.6 15.0 6.6 6.1 15.0 1.2 1 0 0 1 1 1 0 Ribonuclease E/G family KASH_CCD PF14662.6 PIK36018.1 - 5.9 6.7 42.2 0.95 9.3 36.6 2.5 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Sec20 PF03908.13 PIK36018.1 - 7.2 6.6 9.8 5.7 6.9 5.5 2.7 1 1 1 2 2 2 0 Sec20 Sulfotransfer_2 PF03567.14 PIK36019.1 - 1.5e-06 28.3 1.4 2.4e-06 27.6 1.4 1.3 1 0 0 1 1 1 1 Sulfotransferase family SopA PF13981.6 PIK36019.1 - 0.0082 16.6 0.3 0.022 15.2 0.2 1.8 2 0 0 2 2 2 1 SopA-like central domain MtlR PF05068.12 PIK36019.1 - 0.039 14.0 0.1 0.068 13.2 0.1 1.3 1 0 0 1 1 1 0 Mannitol repressor Sir1 PF11603.8 PIK36019.1 - 0.056 13.9 0.6 0.098 13.1 0.6 1.5 1 0 0 1 1 1 0 Regulatory protein Sir1 NIDO PF06119.14 PIK36022.1 - 3.1e-21 76.1 0.5 7.8e-21 74.8 0.5 1.7 1 0 0 1 1 1 1 Nidogen-like Lectin_C PF00059.21 PIK36022.1 - 4.4e-07 30.6 0.2 7.6e-07 29.8 0.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain EF-hand_1 PF00036.32 PIK36023.1 - 3.5e-17 60.6 1.5 2.7e-06 26.5 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK36023.1 - 4.7e-14 51.0 0.2 3e-06 26.7 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 PIK36023.1 - 2.4e-12 47.1 1.2 9.5e-10 38.8 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK36023.1 - 3.3e-11 42.9 1.8 2e-08 33.9 0.2 2.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK36023.1 - 3.5e-07 29.4 0.2 9.3e-05 21.8 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 PIK36023.1 - 0.012 15.9 0.0 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_10 PF14788.6 PIK36023.1 - 0.031 14.1 0.3 13 5.8 0.0 3.3 3 1 1 4 4 4 0 EF hand p450 PF00067.22 PIK36024.1 - 4.1e-34 118.1 5.4 4.7e-24 85.0 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 PhageMin_Tail PF10145.9 PIK36024.1 - 0.051 13.4 0.6 0.09 12.6 0.6 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein p450 PF00067.22 PIK36025.1 - 2.5e-06 26.5 0.1 2.6e-06 26.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK36026.1 - 6e-61 206.6 0.2 7e-61 206.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_10 PF00331.20 PIK36026.1 - 0.08 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 p450 PF00067.22 PIK36027.1 - 1.4e-90 304.3 0.0 1.7e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HECT_2 PF09814.9 PIK36028.1 - 7.4e-16 58.0 7.4 1.2e-15 57.3 7.4 1.2 1 1 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 PIK36028.1 - 0.019 15.2 3.2 2.2 8.6 0.1 2.6 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH_5 PF14279.6 PIK36028.1 - 0.061 13.2 4.1 2.2 8.2 0.7 2.8 2 0 0 2 2 2 0 HNH endonuclease Pox_E6 PF04656.12 PIK36028.1 - 0.067 11.6 0.1 0.089 11.2 0.1 1.1 1 0 0 1 1 1 0 Pox virus E6 protein Zn-ribbon_8 PF09723.10 PIK36028.1 - 0.13 12.4 1.4 14 5.9 0.2 3.4 3 0 0 3 3 3 0 Zinc ribbon domain HNH PF01844.23 PIK36028.1 - 1.1 9.5 8.3 0.65 10.2 0.5 3.2 3 0 0 3 3 3 0 HNH endonuclease DUF678 PF05077.12 PIK36028.1 - 1.4 9.1 6.5 3.2 8.0 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Rhodanese_C PF12368.8 PIK36028.1 - 4 7.9 8.5 1 9.8 1.6 3.1 3 0 0 3 3 3 0 Rhodanase C-terminal Exo_endo_phos PF03372.23 PIK36029.1 - 2.9e-12 46.6 0.0 5.4e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family INPP5B_PH PF16776.5 PIK36029.1 - 0.0096 15.6 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain SpoU_methylas_C PF12105.8 PIK36029.1 - 0.048 13.3 3.7 7.2 6.4 0.0 3.6 3 1 1 4 4 4 0 SpoU, rRNA methylase, C-terminal SR-25 PF10500.9 PIK36029.1 - 0.1 12.2 8.1 0.17 11.4 8.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 PIK36029.1 - 0.31 11.7 7.2 0.59 10.9 7.2 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein RhoGAP PF00620.27 PIK36030.1 - 3.8e-16 59.3 0.4 4.8e-16 58.9 0.4 1.1 1 0 0 1 1 1 1 RhoGAP domain INTS5_N PF14837.6 PIK36030.1 - 0.017 14.7 0.0 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus TPR_19 PF14559.6 PIK36030.1 - 0.14 12.7 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TRAPPC10 PF12584.8 PIK36031.1 - 1.1e-16 61.0 0.0 1.7e-16 60.3 0.0 1.3 1 1 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 AlaDh_PNT_N PF05222.15 PIK36031.1 - 0.095 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, N-terminal domain SNAP PF14938.6 PIK36033.1 - 0.042 13.3 0.3 6.4 6.1 0.1 3.1 3 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP T-box PF00907.22 PIK36034.1 - 2.6e-73 246.2 0.0 3.1e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 T-box Bac_rhamnosid PF05592.11 PIK36034.1 - 0.0015 18.5 0.1 0.0035 17.3 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain zf-C4 PF00105.18 PIK36035.1 - 0.0002 21.8 1.0 0.00031 21.1 1.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK36036.1 - 3.1e-41 141.2 0.0 4.3e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor fn3 PF00041.21 PIK36037.1 - 2.7e-13 50.1 1.3 2.1e-07 31.2 0.7 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK36037.1 - 3.5e-05 24.3 3.9 0.0021 18.6 3.3 2.5 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain REJ PF02010.15 PIK36037.1 - 0.0011 17.8 1.0 0.0059 15.4 1.0 2.0 1 1 0 1 1 1 1 REJ domain GPI-anchored PF10342.9 PIK36037.1 - 0.019 15.7 4.0 0.076 13.8 2.4 2.3 2 1 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CBM_4_9 PF02018.17 PIK36037.1 - 0.055 13.7 1.8 0.38 11.0 0.3 2.5 1 1 1 2 2 2 0 Carbohydrate binding domain Y_phosphatase PF00102.27 PIK36038.1 - 6.8e-56 189.5 0.0 9.8e-49 166.0 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK36038.1 - 0.11 12.3 0.6 0.28 11.0 0.1 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Asp_protease_2 PF13650.6 PIK36039.1 - 0.00047 20.7 0.0 0.0018 18.9 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK36039.1 - 0.0025 18.3 0.0 0.0066 17.0 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 PIK36039.1 - 0.095 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK36039.1 - 6.1 7.1 14.0 0.72 10.0 0.8 2.9 3 0 0 3 3 3 0 Zinc knuckle ADK_lid PF05191.14 PIK36039.1 - 8.1 6.5 7.3 5.2 7.1 4.4 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid RT_RNaseH_2 PF17919.1 PIK36040.1 - 3.4e-33 113.6 0.1 8.6e-33 112.4 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36040.1 - 1.5e-27 95.9 0.0 3e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36040.1 - 2.9e-19 69.5 0.0 7.2e-19 68.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK36040.1 - 1.9e-15 56.7 0.3 1.9e-15 56.7 0.3 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK36040.1 - 2.4e-15 56.7 0.0 5.8e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain CBP_BcsF PF11120.8 PIK36040.1 - 0.16 12.1 0.9 0.32 11.2 0.9 1.5 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF p450 PF00067.22 PIK36041.1 - 1.8e-54 185.2 0.0 2.4e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LPD26 PF18842.1 PIK36041.1 - 0.19 11.7 0.1 0.48 10.4 0.1 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 DUF3311 PF11755.8 PIK36041.1 - 2.4 8.2 4.4 5.9 6.9 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3311) UvrD_C_2 PF13538.6 PIK36042.1 - 4.6e-08 32.8 1.3 7.6e-08 32.1 1.3 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 PIK36042.1 - 0.001 18.9 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 PIK36042.1 - 0.083 12.5 0.0 0.18 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK36043.1 - 1.7e-29 103.0 0.0 4.2e-29 101.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK36043.1 - 2.3e-20 73.4 0.0 3.8e-19 69.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK36043.1 - 4.6e-10 39.7 0.0 0.00048 20.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 PIK36043.1 - 9e-07 28.9 0.0 0.0089 15.8 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 PIK36043.1 - 0.00012 22.3 0.6 0.00046 20.5 0.2 2.1 2 1 0 2 2 1 1 AAA domain Helicase_RecD PF05127.14 PIK36043.1 - 0.0011 18.9 0.1 0.0068 16.3 0.1 2.1 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.6 PIK36043.1 - 0.0052 17.2 0.0 0.015 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 PIK36043.1 - 0.0077 16.3 0.0 0.035 14.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 PIK36043.1 - 0.0091 15.6 0.3 0.025 14.1 0.2 2.1 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Ras PF00071.22 PIK36043.1 - 0.012 15.2 0.2 1.3 8.6 0.0 2.7 3 0 0 3 3 3 0 Ras family AAA_23 PF13476.6 PIK36043.1 - 0.019 15.5 0.1 0.28 11.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 PIK36043.1 - 0.024 14.1 0.0 0.23 10.9 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.22 PIK36043.1 - 0.025 13.8 0.0 0.053 12.7 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 PIK36043.1 - 0.027 14.4 0.1 0.086 12.7 0.1 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_18 PF13238.6 PIK36043.1 - 0.029 14.9 0.0 0.25 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 PIK36043.1 - 0.036 14.0 0.1 10 6.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) cobW PF02492.19 PIK36043.1 - 0.049 13.2 0.0 0.15 11.6 0.0 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 PIK36043.1 - 0.075 13.1 0.3 0.085 12.9 0.3 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 PIK36043.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CDC24_OB1 PF17246.2 PIK36044.1 - 0.058 13.5 0.6 0.42 10.7 0.1 2.4 2 1 0 2 2 2 0 Cell division control protein 24, OB domain 1 RRM_1 PF00076.22 PIK36045.1 - 1.5e-11 44.0 0.0 2.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36045.1 - 0.0046 17.1 0.0 0.013 15.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif DUF3791 PF12668.7 PIK36045.1 - 0.17 11.9 0.2 0.42 10.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) NAD_binding_1 PF00175.21 PIK36046.1 - 1.7e-12 47.9 0.0 5.5e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain SNase PF00565.17 PIK36047.1 - 0.072 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 Staphylococcal nuclease homologue Pkinase PF00069.25 PIK36048.1 - 2.5e-76 256.5 0.0 4.4e-76 255.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36048.1 - 6.8e-43 146.8 0.0 1.2e-42 146.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.23 PIK36048.1 - 1.2e-11 44.2 2.2 3.1e-06 27.0 0.0 5.3 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 PIK36048.1 - 1.9e-09 37.0 1.1 0.016 15.4 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 PIK36048.1 - 1.6e-08 34.8 1.0 1.8e-05 25.1 0.1 3.5 1 1 1 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 PIK36048.1 - 4e-07 30.3 0.4 4.6e-05 23.7 0.1 3.8 2 1 2 4 4 3 2 HEAT repeats Kinase-like PF14531.6 PIK36048.1 - 0.00047 19.6 0.0 0.0029 17.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like V-ATPase_H_N PF03224.14 PIK36048.1 - 0.0021 17.4 1.8 0.0039 16.5 0.1 2.5 3 0 0 3 3 3 1 V-ATPase subunit H APH PF01636.23 PIK36048.1 - 0.0053 16.7 0.1 0.05 13.5 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK36048.1 - 0.007 15.2 0.0 0.007 15.2 0.0 2.1 3 0 0 3 3 3 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK36048.1 - 0.013 14.4 0.0 0.044 12.7 0.0 1.9 1 0 0 1 1 1 0 Haspin like kinase domain Cnd1 PF12717.7 PIK36048.1 - 0.019 15.0 2.8 2 8.4 0.1 3.7 2 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Filament PF00038.21 PIK36048.1 - 8.4 5.9 9.2 0.13 11.8 0.8 1.9 2 0 0 2 2 2 0 Intermediate filament protein V-SNARE_C PF12352.8 PIK36049.1 - 7.5e-11 42.2 3.6 1.4e-10 41.3 0.5 2.7 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus WEMBL PF05701.11 PIK36049.1 - 0.027 13.2 3.2 0.036 12.8 3.2 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light HEAT PF02985.22 PIK36050.1 - 0.059 13.7 0.8 23 5.6 0.2 3.2 3 0 0 3 3 3 0 HEAT repeat Citrate_bind PF16114.5 PIK36050.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding Atx10homo_assoc PF09759.9 PIK36050.1 - 0.063 13.3 0.2 29 4.8 0.0 3.2 2 2 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain RT_RNaseH PF17917.1 PIK36051.1 - 6.4e-20 71.4 0.1 7.2e-11 42.3 0.1 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36051.1 - 9.1e-20 71.1 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK36051.1 - 4.9e-17 61.8 0.0 6.4e-15 55.0 0.0 2.5 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_thumb PF06817.14 PIK36051.1 - 0.00018 21.2 0.0 0.00043 20.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain DUF3613 PF12266.8 PIK36051.1 - 0.018 14.8 0.6 0.89 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) Tnp_P_element_C PF12596.8 PIK36052.1 - 0.04 14.5 0.1 0.068 13.7 0.1 1.5 1 0 0 1 1 1 0 87kDa Transposase Tnp_P_element PF12017.8 PIK36053.1 - 2.8e-17 62.9 0.1 8.5e-17 61.3 0.0 1.9 1 1 1 2 2 2 1 Transposase protein ResIII PF04851.15 PIK36053.1 - 0.0057 16.7 0.2 0.027 14.5 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit YabA PF06156.13 PIK36053.1 - 0.05 14.2 0.5 0.14 12.8 0.5 1.7 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_1 PF00170.21 PIK36053.1 - 0.47 10.6 7.6 3.8 7.7 0.1 3.2 2 1 1 3 3 3 0 bZIP transcription factor RAG1_imp_bd PF12560.8 PIK36054.1 - 2.8e-05 23.8 13.3 5.8e-05 22.8 0.5 3.1 3 0 0 3 3 3 2 RAG1 importin binding zf-AD PF07776.15 PIK36054.1 - 0.012 15.9 0.8 0.012 15.9 0.8 2.5 3 1 1 4 4 4 0 Zinc-finger associated domain (zf-AD) Glyco_trans_1_2 PF13524.6 PIK36054.1 - 0.081 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Tnp_P_element PF12017.8 PIK36055.1 - 9.5e-16 57.9 0.0 1.8e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Transposase protein ResIII PF04851.15 PIK36055.1 - 0.0047 17.0 0.0 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Prok-RING_1 PF14446.6 PIK36056.1 - 0.011 15.6 4.7 0.024 14.5 4.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 PIK36056.1 - 0.11 12.4 8.2 0.24 11.3 8.2 1.6 1 0 0 1 1 1 0 PHD-finger Tnp_P_element_C PF12596.8 PIK36056.1 - 0.12 12.9 0.7 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 87kDa Transposase RVT_1 PF00078.27 PIK36057.1 - 2.3e-18 66.6 0.0 4e-18 65.7 0.1 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) LPD22 PF18834.1 PIK36058.1 - 0.08 13.2 0.0 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 22 DUF4506 PF14958.6 PIK36058.1 - 0.11 12.0 0.4 1.9 8.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4506) WYL_3 PF18488.1 PIK36059.1 - 2.8 8.4 5.4 1.9 8.9 0.7 2.9 3 0 0 3 3 3 0 WYL domain NACHT PF05729.12 PIK36060.1 - 2.4e-06 27.6 0.0 4.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TFIIE_beta PF02186.15 PIK36060.1 - 0.043 14.1 1.1 3 8.2 0.1 3.6 3 0 0 3 3 3 0 TFIIE beta subunit core domain AAA_25 PF13481.6 PIK36060.1 - 0.12 12.0 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain V-set PF07686.17 PIK36061.1 - 2.6e-07 30.8 0.2 0.03 14.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK36061.1 - 1.8e-06 28.5 3.4 0.022 15.4 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK36061.1 - 0.00047 20.3 2.6 0.27 11.5 0.1 3.8 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK36061.1 - 0.14 12.2 1.9 2 8.6 0.0 3.1 3 1 0 3 3 3 0 Immunoglobulin I-set domain NACHT PF05729.12 PIK36062.1 - 6.4e-15 55.5 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK36062.1 - 0.0026 18.0 0.0 0.01 16.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK36062.1 - 0.022 14.3 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 PIK36062.1 - 0.065 12.4 0.0 0.33 10.1 0.0 2.1 1 1 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 PIK36063.1 - 1.8e-14 54.0 0.0 3.6e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK36063.1 - 1.3e-09 38.2 1.4 0.00036 20.7 0.2 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK36063.1 - 1e-08 35.6 3.0 0.0093 16.5 0.1 4.6 3 1 1 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK36063.1 - 3.7e-06 26.9 3.2 0.055 13.6 0.3 3.7 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36063.1 - 4.1e-06 27.0 3.4 0.41 11.0 0.1 4.1 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK36063.1 - 4.3e-05 23.6 4.2 0.56 10.4 0.0 4.0 3 0 0 3 3 3 2 Immunoglobulin domain Chordopox_A13L PF05961.11 PIK36063.1 - 0.014 15.7 0.2 0.042 14.1 0.2 1.9 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Izumo-Ig PF16706.5 PIK36063.1 - 0.02 15.0 0.1 0.1 12.7 0.1 2.2 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain AAA_22 PF13401.6 PIK36063.1 - 0.023 15.0 0.0 0.066 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain C2-set_2 PF08205.12 PIK36063.1 - 0.037 14.1 0.4 0.29 11.2 0.2 2.3 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ECSCR PF15820.5 PIK36063.1 - 0.051 13.4 1.1 0.22 11.4 0.7 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator AAA_25 PF13481.6 PIK36063.1 - 0.059 12.9 0.0 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Pilin_N PF07790.11 PIK36063.1 - 0.082 13.8 2.8 0.29 12.1 2.8 2.0 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal Insulin_TMD PF17870.1 PIK36063.1 - 0.14 12.2 6.2 0.38 10.8 6.2 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4834 PF16118.5 PIK36063.1 - 0.16 13.0 0.6 0.51 11.3 0.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) GRAM PF02893.20 PIK36064.1 - 5.2e-39 132.6 1.2 1.3e-20 73.4 0.1 2.2 2 0 0 2 2 2 2 GRAM domain DUF445 PF04286.12 PIK36064.1 - 0.0019 18.1 0.0 0.0054 16.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF445) DIOX_N PF14226.6 PIK36064.1 - 0.05 14.4 0.0 2.4 8.9 0.1 2.6 2 1 0 2 2 2 0 non-haem dioxygenase in morphine synthesis N-terminal Caskin1-CID PF16600.5 PIK36064.1 - 0.45 11.1 5.9 1.2 9.8 5.9 1.7 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain zf-C2H2 PF00096.26 PIK36065.1 - 0.012 16.1 6.5 0.36 11.4 1.0 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type DRMBL PF07522.14 PIK36065.1 - 0.044 14.0 0.9 0.62 10.3 0.1 2.4 1 1 1 2 2 2 0 DNA repair metallo-beta-lactamase FOXP-CC PF16159.5 PIK36065.1 - 0.26 11.9 4.6 8.9 7.0 0.1 2.8 1 1 1 2 2 2 0 FOXP coiled-coil domain BRICHOS PF04089.14 PIK36067.1 - 0.0058 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain 4HB_MCP_1 PF12729.7 PIK36068.1 - 0.48 10.0 2.2 0.8 9.2 2.2 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction CoxIIa PF08113.11 PIK36068.1 - 1.3 8.9 7.5 2.2 8.1 7.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family zf-B_box PF00643.24 PIK36070.1 - 3.8e-13 49.4 18.7 1.1e-11 44.7 4.5 2.3 2 0 0 2 2 2 2 B-box zinc finger Apolipoprotein PF01442.18 PIK36070.1 - 0.00043 20.2 1.9 0.0006 19.7 1.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain JIP_LZII PF16471.5 PIK36070.1 - 0.08 13.1 5.6 0.16 12.2 1.7 2.8 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Cnn_1N PF07989.11 PIK36070.1 - 0.089 13.0 2.4 0.29 11.3 2.1 2.1 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Laminin_II PF06009.12 PIK36070.1 - 0.34 10.9 8.4 0.039 14.0 2.6 2.2 2 1 1 3 3 3 0 Laminin Domain II DUF883 PF05957.13 PIK36070.1 - 0.53 10.9 2.5 0.51 11.0 0.7 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ribosomal_S20p PF01649.18 PIK36070.1 - 1.4 9.6 6.9 4.1 8.1 3.2 2.7 2 1 1 3 3 3 0 Ribosomal protein S20 FlaC_arch PF05377.11 PIK36070.1 - 5.8 7.4 7.8 3.4 8.1 1.3 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) IBR PF01485.21 PIK36070.1 - 7.1 6.9 13.8 2.2 8.6 3.4 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain HIP1_clath_bdg PF16515.5 PIK36070.1 - 9.2 6.9 9.2 1.6 9.4 3.4 2.5 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SLBP_RNA_bind PF15247.6 PIK36071.1 - 0.8 9.9 3.0 1.7 8.8 1.3 2.2 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain SSF PF00474.17 PIK36073.1 - 3.2e-29 102.0 21.3 3.2e-29 102.0 21.3 6.0 2 1 1 3 3 3 1 Sodium:solute symporter family SR-25 PF10500.9 PIK36073.1 - 2.2e-05 24.2 17.3 3.3e-05 23.6 17.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 PIK36073.1 - 7e-05 23.7 8.8 7e-05 23.7 8.8 8.4 3 1 1 4 4 4 1 Domain of unknown function (DUF4834) FAM176 PF14851.6 PIK36073.1 - 0.09 12.4 0.3 0.45 10.2 0.0 2.3 2 0 0 2 2 2 0 FAM176 family DUF3446 PF11928.8 PIK36073.1 - 0.12 12.7 20.2 0.23 11.8 20.2 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain DUF2946 PF11162.8 PIK36073.1 - 0.26 12.0 9.1 1 10.1 9.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) CCDC24 PF15669.5 PIK36073.1 - 0.49 10.2 4.0 0.74 9.6 4.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Velvet PF11754.8 PIK36073.1 - 0.85 9.5 5.6 1.3 8.9 5.6 1.2 1 0 0 1 1 1 0 Velvet factor CCDC106 PF15794.5 PIK36073.1 - 0.94 9.2 12.3 1.4 8.6 12.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF1635 PF07795.11 PIK36073.1 - 3.9 7.3 11.7 5.9 6.7 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) IL17 PF06083.11 PIK36075.1 - 4.1e-22 78.5 4.1 6.7e-22 77.8 4.1 1.4 1 0 0 1 1 1 1 Interleukin-17 IL17 PF06083.11 PIK36076.1 - 3.2e-19 69.2 2.4 4.5e-19 68.7 2.4 1.2 1 0 0 1 1 1 1 Interleukin-17 Glyco_transf_49 PF13896.6 PIK36076.1 - 0.0062 15.9 0.0 0.0075 15.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan COX6C PF02937.15 PIK36077.1 - 6.1e-28 96.8 0.6 7.4e-28 96.5 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc HTH_IclR PF09339.10 PIK36077.1 - 0.03 14.1 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Methyltransf_15 PF09445.10 PIK36078.1 - 0.00017 21.2 0.0 0.00018 21.2 0.0 1.0 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_15 PF09445.10 PIK36079.1 - 3e-31 108.2 0.1 4.1e-31 107.8 0.1 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 PIK36079.1 - 8.8e-09 35.4 0.1 1.4e-08 34.8 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 PIK36079.1 - 2.3e-08 34.6 0.1 2e-07 31.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 PIK36079.1 - 7.6e-08 32.3 0.0 1.7e-05 24.6 0.0 2.9 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 PIK36079.1 - 1.6e-06 28.0 0.0 3.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36079.1 - 0.00022 21.8 0.1 0.0014 19.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 PIK36079.1 - 0.00044 20.2 0.0 0.0009 19.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK36079.1 - 0.00046 19.9 0.0 0.0008 19.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 PIK36079.1 - 0.0051 16.2 0.0 0.0081 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 PIK36079.1 - 0.011 15.3 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RT_RNaseH_2 PF17919.1 PIK36080.1 - 7.2e-24 83.7 0.0 8.6e-24 83.5 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36080.1 - 2.6e-11 43.7 0.0 3.9e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Neur_chan_LBD PF02931.23 PIK36081.1 - 1.3e-18 67.3 0.4 2e-18 66.7 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain ERp29_N PF07912.13 PIK36082.1 - 4.1e-33 114.2 0.5 6.2e-33 113.6 0.1 1.5 2 0 0 2 2 2 1 ERp29, N-terminal domain ERp29 PF07749.12 PIK36082.1 - 5.9e-22 78.4 4.2 1.1e-21 77.5 4.2 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Gluconate_2-dh3 PF13618.6 PIK36082.1 - 0.059 13.6 1.0 0.091 13.0 0.8 1.4 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 Ras PF00071.22 PIK36083.1 - 2.4e-08 33.8 0.0 3.3e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK36083.1 - 1.5e-06 28.4 0.0 2.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK36083.1 - 0.00068 19.7 0.0 0.00082 19.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 PIK36083.1 - 0.002 17.4 0.0 0.0022 17.2 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 PIK36083.1 - 0.0032 16.9 0.0 0.0049 16.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF4318 PF14201.6 PIK36083.1 - 0.013 16.0 0.2 0.03 14.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) FeoB_N PF02421.18 PIK36083.1 - 0.049 13.2 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.6 PIK36083.1 - 0.082 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 PIK36083.1 - 0.097 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 PIK36083.1 - 0.1 13.0 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 PIK36083.1 - 0.16 11.5 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 PIK36083.1 - 0.21 11.0 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Y_phosphatase PF00102.27 PIK36084.1 - 2e-107 358.1 3.5 1.5e-55 188.4 0.1 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK36084.1 - 1.8e-08 34.3 0.6 0.0016 18.2 0.2 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK36084.1 - 0.00038 20.5 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK36084.1 - 0.0019 18.3 0.0 0.053 13.6 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Myotub-related PF06602.14 PIK36084.1 - 0.043 12.7 0.4 2.9 6.7 0.2 2.3 2 0 0 2 2 2 0 Myotubularin-like phosphatase domain DUF2347 PF09804.9 PIK36085.1 - 2.5e-62 211.1 0.0 3.1e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 PIK36085.1 - 2.5e-09 36.3 0.0 2.7e-05 23.0 0.0 2.1 2 0 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 PIK36085.1 - 0.00014 21.8 0.0 0.00026 20.9 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Ntox17 PF15524.6 PIK36086.1 - 0.085 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Novel toxin 17 Peptidase_S66 PF02016.15 PIK36087.1 - 0.01 16.0 0.0 0.026 14.6 0.0 1.7 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain Sulfotransfer_1 PF00685.27 PIK36088.1 - 6.3e-05 22.6 0.2 8.1e-05 22.2 0.2 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK36089.1 - 1.1e-07 31.6 0.8 2.2e-07 30.6 0.3 1.7 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK36089.1 - 2.4e-06 28.1 0.8 0.00053 20.4 0.4 2.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_4 PF17784.1 PIK36089.1 - 0.0035 17.2 2.3 0.0052 16.6 0.5 2.2 2 1 0 2 2 2 1 Sulfotransferase domain FTO_CTD PF12934.7 PIK36089.1 - 0.0083 15.9 0.2 0.017 14.9 0.2 1.4 1 0 0 1 1 1 1 FTO C-terminal domain Ig_3 PF13927.6 PIK36090.1 - 4e-06 27.3 0.3 3.7e-05 24.2 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK36090.1 - 5.5e-05 23.3 0.1 0.00015 21.8 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK36090.1 - 0.00011 22.3 0.1 0.00026 21.1 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK36090.1 - 0.0029 17.7 0.0 0.0084 16.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Izumo-Ig PF16706.5 PIK36090.1 - 0.015 15.4 0.0 0.26 11.4 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain SUKH_6 PF14568.6 PIK36090.1 - 0.12 12.8 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Ig_3 PF13927.6 PIK36091.1 - 6.9e-06 26.6 2.0 0.017 15.7 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK36091.1 - 0.00062 19.9 0.9 0.0091 16.2 0.1 2.6 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK36091.1 - 0.0016 18.4 0.1 0.014 15.4 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 PIK36091.1 - 0.0074 16.5 0.5 0.33 11.1 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK36092.1 - 1.2e-31 110.0 0.0 1.6e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36092.1 - 2.4e-14 53.4 0.0 3.9e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ig PF00047.25 PIK36092.1 - 0.018 15.2 0.1 0.044 13.9 0.1 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Kinase-like PF14531.6 PIK36092.1 - 0.088 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Glyco_hydro_79n PF03662.14 PIK36094.1 - 1.8e-20 73.2 0.0 2.6e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 79, N-terminal domain Glyco_hydro_cc PF11790.8 PIK36094.1 - 0.00015 21.4 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF758 PF05527.11 PIK36094.1 - 0.21 11.6 0.3 0.49 10.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF758) MtrG PF04210.13 PIK36095.1 - 0.0081 16.0 5.1 0.66 9.9 0.3 3.7 2 2 2 4 4 4 1 Tetrahydromethanopterin S-methyltransferase, subunit G Baculo_PEP_C PF04513.12 PIK36095.1 - 0.01 15.9 0.1 0.025 14.6 0.1 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Alpha-2-MRAP_C PF06401.11 PIK36095.1 - 0.011 15.8 0.8 0.014 15.4 0.8 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF922 PF06037.11 PIK36095.1 - 0.021 14.6 0.2 0.036 13.9 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Transposase_22 PF02994.14 PIK36095.1 - 0.028 14.6 0.4 0.12 12.6 0.0 2.2 2 2 0 2 2 2 0 L1 transposable element RBD-like domain Med9 PF07544.13 PIK36095.1 - 0.038 14.1 4.7 0.29 11.3 0.5 2.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Occludin_ELL PF07303.13 PIK36095.1 - 0.039 14.7 1.4 0.074 13.8 0.8 1.9 2 0 0 2 2 2 0 Occludin homology domain NPV_P10 PF05531.12 PIK36095.1 - 0.041 14.4 0.6 2.9 8.4 0.3 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 PIK36095.1 - 0.051 14.0 8.1 0.1 13.0 3.8 2.9 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 PIK36095.1 - 0.06 13.4 2.5 0.28 11.2 1.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 PIK36095.1 - 0.061 13.8 4.0 0.13 12.7 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 TMF_TATA_bd PF12325.8 PIK36095.1 - 0.062 13.5 6.7 0.052 13.8 2.3 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 PIK36095.1 - 0.093 11.6 4.5 0.13 11.1 4.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 PIK36095.1 - 0.11 13.1 3.0 0.24 12.1 3.0 1.7 1 1 0 1 1 1 0 Initiation control protein YabA BLOC1_2 PF10046.9 PIK36095.1 - 0.16 12.3 5.3 0.19 12.0 1.1 2.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 V_ATPase_I PF01496.19 PIK36095.1 - 0.16 9.8 1.0 0.18 9.7 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2730 PF10805.8 PIK36095.1 - 0.42 10.7 2.8 1.7 8.8 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) rve PF00665.26 PIK36096.1 - 1.1e-19 70.7 0.2 3.2e-19 69.3 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK36096.1 - 0.0091 15.8 0.6 0.019 14.7 0.1 1.9 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK36097.1 - 1.5e-32 111.5 0.1 3.9e-32 110.3 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36097.1 - 7.1e-28 97.0 0.0 1.6e-27 95.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36097.1 - 3.2e-07 30.1 0.0 0.001 18.6 0.1 2.7 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK36097.1 - 0.00032 20.7 0.4 0.0012 18.9 0.4 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain RhoGAP PF00620.27 PIK36098.1 - 6.1e-29 100.8 0.0 9.7e-29 100.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.17 PIK36098.1 - 4.6e-27 94.6 0.0 9.5e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 MyTH4 domain Y_phosphatase PF00102.27 PIK36099.1 - 2.1e-15 57.0 0.3 0.00018 21.1 0.1 3.2 2 1 1 3 3 3 3 Protein-tyrosine phosphatase 7tm_2 PF00002.24 PIK36101.1 - 1.1e-13 51.1 1.4 1.4e-13 50.7 1.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Sre PF03125.18 PIK36101.1 - 2.1e-05 23.8 0.2 2.1e-05 23.8 0.2 1.6 2 0 0 2 2 2 1 C. elegans Sre G protein-coupled chemoreceptor DUF2985 PF11204.8 PIK36101.1 - 0.0068 16.5 1.0 0.047 13.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) DUF1201 PF06716.11 PIK36101.1 - 0.015 15.3 0.9 0.015 15.3 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Glycos_transf_2 PF00535.26 PIK36102.1 - 2.3e-11 43.8 0.0 3e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 PIK36102.1 - 1e-05 25.1 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK36102.1 - 0.0027 17.2 0.0 0.0061 16.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Ricin_B_lectin PF00652.22 PIK36103.1 - 1.1e-11 45.1 0.1 1.2e-11 44.9 0.1 1.0 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Ig_3 PF13927.6 PIK36104.1 - 1.2e-07 32.2 9.4 0.002 18.7 0.3 4.1 3 2 1 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK36104.1 - 1e-06 28.8 4.3 0.055 13.6 0.1 4.1 2 1 3 5 5 5 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK36104.1 - 1.8e-06 27.9 1.2 7.8e-06 25.9 0.0 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK36104.1 - 3.1e-05 24.1 0.2 3.1e-05 24.1 0.2 2.7 2 1 2 4 4 4 1 Immunoglobulin V-set domain I-set PF07679.16 PIK36104.1 - 4.4e-05 23.5 7.5 0.055 13.5 1.2 3.7 3 1 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 PIK36104.1 - 0.027 14.8 1.8 0.33 11.4 0.0 3.3 3 0 0 3 3 3 0 Immunoglobulin C1-set domain DUF4448 PF14610.6 PIK36104.1 - 0.032 14.0 0.1 0.056 13.2 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 PIK36104.1 - 0.38 10.2 4.3 0.67 9.4 4.3 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMEM154 PF15102.6 PIK36105.1 - 9.1e-07 28.9 0.1 2.6e-06 27.4 0.1 1.8 1 0 0 1 1 1 1 TMEM154 protein family C2-set_2 PF08205.12 PIK36105.1 - 1.2e-06 28.5 1.1 3.9e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK36105.1 - 0.00014 22.0 1.7 0.029 14.5 0.0 3.0 3 0 0 3 3 2 1 Immunoglobulin domain DUF4448 PF14610.6 PIK36105.1 - 0.00022 21.0 0.1 0.00041 20.2 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) Adeno_E3_CR2 PF02439.15 PIK36105.1 - 0.00031 20.5 3.5 0.00065 19.4 3.5 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Ig_3 PF13927.6 PIK36105.1 - 0.00034 21.2 5.8 0.014 16.0 0.2 3.5 3 2 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK36105.1 - 0.0017 18.4 3.8 0.11 12.6 0.3 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain PRIMA1 PF16101.5 PIK36105.1 - 0.0042 17.1 0.5 3.9 7.5 0.0 2.4 2 0 0 2 2 2 2 Proline-rich membrane anchor 1 DUF3566 PF12089.8 PIK36105.1 - 0.0092 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Transmembrane domain of unknown function (DUF3566) C1-set PF07654.15 PIK36105.1 - 0.015 15.7 0.4 0.12 12.8 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain OAD_gamma PF04277.13 PIK36105.1 - 0.028 15.0 0.4 0.06 13.9 0.4 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SKG6 PF08693.10 PIK36105.1 - 0.031 13.7 8.4 0.057 12.8 8.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RIFIN PF02009.16 PIK36105.1 - 0.032 14.1 0.5 0.042 13.7 0.5 1.2 1 0 0 1 1 1 0 Rifin DUF3377 PF11857.8 PIK36105.1 - 0.055 13.4 0.0 0.18 11.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EphA2_TM PF14575.6 PIK36105.1 - 0.058 14.3 0.0 0.12 13.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.11 PIK36105.1 - 0.063 13.3 0.5 0.7 9.8 0.0 2.1 2 0 0 2 2 2 0 Protocadherin FAM209 PF15206.6 PIK36105.1 - 0.077 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 FAM209 family Chordopox_A13L PF05961.11 PIK36105.1 - 0.11 12.8 0.4 0.22 11.8 0.4 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Holin_BhlA PF10960.8 PIK36105.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 BhlA holin family DUF3617 PF12276.8 PIK36105.1 - 0.46 10.8 5.0 0.13 12.5 0.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3617) Insulin_TMD PF17870.1 PIK36105.1 - 0.8 9.8 8.0 0.15 12.2 3.5 2.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment NACHT PF05729.12 PIK36106.1 - 4.3e-15 56.0 0.1 8.3e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK36106.1 - 3.9e-10 40.2 1.9 1.9 9.1 0.0 5.2 5 1 0 5 5 4 4 Immunoglobulin domain C2-set_2 PF08205.12 PIK36106.1 - 1.1e-08 35.1 1.1 0.00085 19.3 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK36106.1 - 5.2e-07 29.7 3.0 2.1 8.6 0.0 5.2 5 1 0 5 5 5 3 Immunoglobulin domain NB-ARC PF00931.22 PIK36106.1 - 1.1e-06 28.1 0.7 2.6e-06 26.8 0.7 1.6 1 0 0 1 1 1 1 NB-ARC domain V-set PF07686.17 PIK36106.1 - 0.0001 22.4 0.1 0.79 9.9 0.0 3.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain ResIII PF04851.15 PIK36106.1 - 0.0025 17.8 0.2 0.0076 16.3 0.2 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 PIK36106.1 - 0.0064 16.5 0.9 0.018 15.1 0.7 1.8 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 PIK36106.1 - 0.028 13.8 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein IstB_IS21 PF01695.17 PIK36106.1 - 0.044 13.5 0.1 0.94 9.2 0.1 2.4 1 1 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 PIK36106.1 - 0.11 12.9 0.0 0.35 11.3 0.0 2.0 1 0 0 1 1 1 0 RNA helicase EphA2_TM PF14575.6 PIK36106.1 - 0.12 13.3 0.1 0.3 12.0 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AAA_22 PF13401.6 PIK36106.1 - 0.17 12.2 0.0 0.64 10.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.17 PIK36107.1 - 3e-29 102.1 0.2 4.3e-29 101.6 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36107.1 - 2e-15 56.9 0.0 3.2e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK36107.1 - 0.025 14.9 0.3 0.069 13.5 0.3 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK36108.1 - 9.4e-11 41.5 0.0 1e-10 41.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36108.1 - 0.00013 21.4 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF2083 PF09856.9 PIK36108.1 - 0.042 13.7 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) Pkinase_Tyr PF07714.17 PIK36109.1 - 7e-50 169.7 0.0 1.1e-49 169.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36109.1 - 2.4e-18 66.5 0.0 4.5e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK36109.1 - 3.5e-09 37.1 1.2 7.4e-05 23.3 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK36109.1 - 7.9e-06 26.0 0.2 0.00046 20.3 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK36109.1 - 2.8e-05 24.2 2.0 0.0016 18.6 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK36109.1 - 0.0016 18.4 0.5 0.034 14.2 0.0 2.9 3 0 0 3 3 3 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK36109.1 - 0.0066 16.5 0.1 0.014 15.4 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK36109.1 - 0.009 15.6 0.1 0.026 14.1 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Shisa PF13908.6 PIK36109.1 - 0.04 14.2 0.1 0.096 12.9 0.1 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Aldo_ket_red PF00248.21 PIK36110.1 - 1.4e-48 165.7 0.1 2.2e-48 165.0 0.1 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family DUF2922 PF11148.8 PIK36110.1 - 0.12 12.1 0.2 2.2 8.0 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2922) RIH_assoc PF08454.11 PIK36110.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 RyR and IP3R Homology associated SSF PF00474.17 PIK36111.1 - 4.4e-42 144.4 26.6 5.4e-42 144.1 26.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family CARD PF00619.21 PIK36113.1 - 1.6e-10 40.9 1.6 8.4e-05 22.5 0.1 3.2 2 0 0 2 2 2 2 Caspase recruitment domain DED PF01335.21 PIK36116.1 - 0.0033 17.7 0.1 0.013 15.8 0.1 2.0 1 1 0 1 1 1 1 Death effector domain Med11 PF10280.9 PIK36116.1 - 0.012 16.1 0.0 0.019 15.5 0.0 1.3 1 0 0 1 1 1 0 Mediator complex protein VKG_Carbox PF05090.14 PIK36117.1 - 3.2e-125 418.4 25.0 1.3e-65 222.0 14.6 2.2 1 1 1 2 2 2 2 Vitamin K-dependent gamma-carboxylase DoxX PF07681.12 PIK36117.1 - 0.0031 18.1 3.1 0.093 13.3 0.6 3.1 2 0 0 2 2 2 1 DoxX ISK_Channel PF02060.15 PIK36117.1 - 0.024 14.3 0.0 0.093 12.5 0.0 2.0 1 0 0 1 1 1 0 Slow voltage-gated potassium channel Pro_isomerase PF00160.21 PIK36118.1 - 3.5e-48 163.8 0.2 3.9e-48 163.7 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4175 PF13779.6 PIK36120.1 - 0.0067 14.4 4.7 0.011 13.8 4.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) DUF4554 PF15091.6 PIK36120.1 - 0.18 10.6 1.9 0.3 9.9 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Csm1_N PF18504.1 PIK36121.1 - 0.11 12.9 0.5 0.11 12.9 0.5 3.4 3 0 0 3 3 3 0 Csm1 N-terminal domain MRP-S27 PF10037.9 PIK36121.1 - 6.4 5.5 17.3 0.3 9.9 10.8 1.9 2 1 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 EamA PF00892.20 PIK36122.1 - 6.2e-21 75.0 29.3 5.7e-11 42.7 10.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family fn3 PF00041.21 PIK36123.1 - 5.6e-05 23.4 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Kazal_2 PF07648.15 PIK36124.1 - 1.5e-09 37.8 5.1 1.5e-09 37.8 5.1 1.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK36124.1 - 3e-07 30.4 2.8 3e-07 30.4 2.8 1.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain DUF4045 PF13254.6 PIK36124.1 - 0.4 10.3 21.9 0.57 9.8 21.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CCSAP PF15748.5 PIK36124.1 - 9.5 6.3 21.7 19 5.3 21.7 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Rsm1 PF08600.10 PIK36125.1 - 9.7e-16 57.7 4.3 8.7e-15 54.7 0.9 2.9 2 1 0 2 2 2 1 Rsm1-like zf-C3HC PF07967.13 PIK36125.1 - 3.6e-10 40.0 5.0 2.8e-07 30.6 0.2 3.2 2 1 1 3 3 3 2 C3HC zinc finger-like UQ_con PF00179.26 PIK36126.1 - 7.8e-38 129.3 0.0 1e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RVT_1 PF00078.27 PIK36127.1 - 1.5e-11 44.2 0.1 1.7e-11 44.1 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK36128.1 - 9.7e-13 48.1 0.2 1.4e-12 47.6 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK36130.1 - 4e-54 183.8 0.0 5e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK36131.1 - 2e-09 37.1 3.9 3e-09 36.6 3.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK36131.1 - 0.00042 19.7 3.2 0.00053 19.4 3.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Pkinase PF00069.25 PIK36132.1 - 4.4e-23 82.0 0.0 5.3e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36132.1 - 9.3e-15 54.6 0.0 1.3e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK36132.1 - 3.4e-05 23.3 0.0 4.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK36132.1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK36132.1 - 0.013 14.5 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 PIK36132.1 - 0.045 13.7 0.3 0.086 12.7 0.3 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK36132.1 - 0.098 11.4 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK36132.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RT_RNaseH PF17917.1 PIK36134.1 - 3.7e-39 133.2 0.0 6.2e-39 132.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK36134.1 - 9.2e-36 121.9 0.0 1.6e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PHD PF00628.29 PIK36134.1 - 2.6e-07 30.4 10.0 7.1e-07 29.0 10.0 1.8 1 1 0 1 1 1 1 PHD-finger FGAR-AT_linker PF18072.1 PIK36134.1 - 0.0017 18.9 0.0 13 6.4 0.0 3.4 3 0 0 3 3 3 1 Formylglycinamide ribonucleotide amidotransferase linker domain RNA_pol_Rpb2_4 PF04566.13 PIK36134.1 - 0.13 12.6 0.0 1 9.7 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 4 PHD_2 PF13831.6 PIK36134.1 - 4.4 6.9 11.0 3.4 7.3 6.6 2.3 1 1 1 2 2 2 0 PHD-finger zf-RVT PF13966.6 PIK36135.1 - 4.7e-06 27.2 0.6 4.7e-06 27.2 0.6 2.1 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase BEN PF10523.9 PIK36138.1 - 6.7e-06 26.3 0.0 2e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 BEN domain TPR_MLP1_2 PF07926.12 PIK36138.1 - 0.0023 18.0 3.0 0.0039 17.2 2.4 1.7 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein TSC22 PF01166.18 PIK36138.1 - 0.0035 17.6 1.2 0.0088 16.3 1.2 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF3450 PF11932.8 PIK36138.1 - 0.0072 15.7 1.6 0.01 15.1 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) EzrA PF06160.12 PIK36138.1 - 0.0084 14.3 0.4 0.011 13.9 0.4 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Nnf1 PF03980.14 PIK36138.1 - 0.037 14.4 0.6 0.074 13.4 0.6 1.6 1 0 0 1 1 1 0 Nnf1 SUN PF03856.13 PIK36138.1 - 0.055 12.9 0.0 0.09 12.2 0.0 1.2 1 0 0 1 1 1 0 Beta-glucosidase (SUN family) AAA_23 PF13476.6 PIK36138.1 - 0.075 13.5 0.5 0.11 12.9 0.5 1.2 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 PIK36138.1 - 0.08 12.3 1.9 0.14 11.5 1.9 1.3 1 0 0 1 1 1 0 FAM76 protein Spc7 PF08317.11 PIK36138.1 - 0.086 11.7 1.8 0.13 11.2 1.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Pox_A_type_inc PF04508.12 PIK36138.1 - 0.087 12.7 1.6 0.17 11.8 0.4 2.1 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat SlyX PF04102.12 PIK36138.1 - 0.11 13.2 1.5 0.46 11.1 1.5 2.1 1 1 0 1 1 1 0 SlyX ADIP PF11559.8 PIK36138.1 - 0.16 12.1 3.7 0.27 11.3 3.7 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Prominin PF05478.11 PIK36138.1 - 0.32 8.9 0.8 0.44 8.5 0.8 1.1 1 0 0 1 1 1 0 Prominin DivIC PF04977.15 PIK36138.1 - 0.43 10.4 2.3 0.74 9.6 1.9 1.6 1 1 0 1 1 1 0 Septum formation initiator DUF4218 PF13960.6 PIK36140.1 - 0.042 13.5 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Hairy_orange PF07527.13 PIK36141.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Hairy Orange Mfa_like_2 PF15415.6 PIK36142.1 - 0.018 14.0 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin-like Dimer_Tnp_hAT PF05699.14 PIK36143.1 - 1.1e-09 37.9 0.4 2.5e-09 36.8 0.4 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region HYR PF02494.16 PIK36144.1 - 2.5e-187 607.7 73.4 5.1e-25 87.6 3.4 10.0 9 1 1 10 10 10 10 HYR domain FAM194 PF14977.6 PIK36144.1 - 8.7e-06 25.2 10.6 3.6 6.8 0.1 6.4 7 0 0 7 7 7 2 FAM194 protein Spindle_Spc25 PF08234.12 PIK36144.1 - 0.00065 19.9 3.3 1.3 9.3 0.0 5.0 6 0 0 6 6 6 1 Chromosome segregation protein Spc25 Phage_TAC_7 PF10109.9 PIK36144.1 - 0.073 13.2 0.0 1.4e+02 2.6 0.0 3.6 3 0 0 3 3 3 0 Phage tail assembly chaperone proteins, E, or 41 or 14 FTR_C PF02741.15 PIK36144.1 - 0.3 11.1 3.6 50 3.9 0.0 4.7 6 0 0 6 6 6 0 FTR, proximal lobe 7tm_2 PF00002.24 PIK36145.1 - 2.1e-24 86.2 16.0 3e-24 85.6 16.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK36145.1 - 1.3e-11 44.8 2.2 2.3e-11 44.0 2.2 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Phage_holin_3_6 PF07332.11 PIK36145.1 - 6.8 6.8 9.6 0.35 10.9 0.3 2.7 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III RVT_1 PF00078.27 PIK36147.1 - 4.2e-18 65.7 0.1 1.4e-17 64.0 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK36148.1 - 5e-22 77.8 0.3 8.3e-22 77.1 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK36148.1 - 2.2e-07 31.0 0.0 4.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Y_phosphatase PF00102.27 PIK36149.1 - 9.7e-84 280.6 3.5 1.1e-83 280.4 1.8 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK36149.1 - 4.3e-15 55.8 16.4 0.0017 18.6 1.4 7.8 8 0 0 8 8 8 4 Fibronectin type III domain PTPlike_phytase PF14566.6 PIK36149.1 - 0.0022 18.1 0.0 0.0072 16.4 0.0 1.8 1 1 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 PIK36149.1 - 0.0044 16.8 0.8 0.015 15.1 0.1 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK36149.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF2012 PF09430.10 PIK36149.1 - 0.06 13.5 0.1 2 8.6 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) Colicin_V PF02674.16 PIK36149.1 - 0.095 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Colicin V production protein Ricin_B_lectin PF00652.22 PIK36150.1 - 9.1e-18 64.7 1.2 1.4e-17 64.1 1.2 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 PIK36150.1 - 1.2e-06 28.1 0.0 2.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase DUF4570 PF15134.6 PIK36151.1 - 6.9e-05 22.8 2.3 0.00024 21.1 2.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) XhlA PF10779.9 PIK36152.1 - 0.16 12.2 6.5 0.6 10.4 0.2 2.8 3 0 0 3 3 3 0 Haemolysin XhlA ABC_tran_CTD PF16326.5 PIK36152.1 - 0.41 10.9 5.9 8.1 6.8 0.4 3.6 3 2 0 3 3 3 0 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 PIK36152.1 - 3.9 7.6 11.0 25 5.0 7.0 3.2 2 2 0 2 2 2 0 Tropomyosin like Matrilin_ccoil PF10393.9 PIK36152.1 - 4.1 7.3 8.4 6.2 6.8 0.4 3.8 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Gal4_dimer PF03902.13 PIK36152.1 - 7.1 6.9 6.6 37 4.6 0.2 3.1 2 1 0 2 2 2 0 Gal4-like dimerisation domain BRE1 PF08647.11 PIK36153.1 - 8.3e-05 22.6 26.6 0.00023 21.2 2.3 24.3 9 5 10 24 24 24 7 BRE1 E3 ubiquitin ligase ERM PF00769.19 PIK36153.1 - 0.0042 16.9 53.6 0.0042 16.9 53.6 14.4 2 2 13 15 15 15 4 Ezrin/radixin/moesin family SAP PF02037.27 PIK36153.1 - 2.1 8.2 8.2 0.26 11.1 0.2 4.0 4 0 0 4 4 4 0 SAP domain Suf PF05843.14 PIK36155.1 - 4e-06 27.0 0.2 4e-06 27.0 0.2 2.9 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 PIK36155.1 - 6.4e-06 26.6 0.0 2.7 9.0 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK36155.1 - 0.028 13.6 0.1 4.3 6.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Sigma70_ner PF04546.13 PIK36155.1 - 1.1 9.1 11.7 1.6 8.5 2.1 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Mad3_BUB1_I PF08311.12 PIK36155.1 - 1.4 8.9 9.3 1.4 8.9 0.2 3.9 3 1 0 3 3 3 0 Mad3/BUB1 homology region 1 LRIF1 PF15741.5 PIK36156.1 - 0.0037 15.9 0.6 0.0044 15.6 0.6 1.1 1 0 0 1 1 1 1 Ligand-dependent nuclear receptor-interacting factor 1 LisH_TPL PF17814.1 PIK36157.1 - 3e-06 26.8 0.0 5.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 LisH-like dimerisation domain WD40 PF00400.32 PIK36158.1 - 1.7e-07 31.8 2.5 3.1e-06 27.8 0.6 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK36158.1 - 0.0067 15.4 0.0 0.0084 15.1 0.0 1.1 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 PIK36158.1 - 0.18 10.1 0.0 0.21 9.9 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Cadherin_C_2 PF16492.5 PIK36159.1 - 0.0084 16.8 0.3 0.079 13.7 0.0 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal LRR_8 PF13855.6 PIK36161.1 - 2.6e-23 81.6 41.0 3.6e-09 36.3 2.1 5.0 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK36161.1 - 3e-12 46.5 22.0 0.0004 20.7 0.8 6.4 4 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK36161.1 - 4.6e-08 33.1 2.8 2.4e-06 27.5 0.2 2.9 2 1 2 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK36161.1 - 1.5e-05 24.6 4.2 0.028 13.9 0.1 2.8 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 PIK36161.1 - 0.19 12.4 14.7 36 5.4 0.1 7.2 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK36161.1 - 2 8.6 12.8 25 5.2 0.1 6.5 7 0 0 7 7 7 0 Leucine Rich repeat TruB_N PF01509.18 PIK36162.1 - 2.7e-06 27.8 0.0 4.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Ribosomal_L28e PF01778.17 PIK36163.1 - 2.1e-25 89.7 0.4 3.1e-25 89.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family TSCPD PF12637.7 PIK36163.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 TSCPD domain Het-C PF07217.11 PIK36165.1 - 0.11 11.0 0.5 0.12 10.9 0.5 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C ABC2_membrane PF01061.24 PIK36166.1 - 4.4e-11 42.6 4.5 6.1e-11 42.1 4.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter IgGFc_binding PF17517.2 PIK36167.1 - 1.6e-54 185.2 0.2 3.1e-54 184.2 0.2 1.5 1 0 0 1 1 1 1 IgGFc binding protein HYR PF02494.16 PIK36167.1 - 2.3e-18 66.3 7.0 4.2e-11 43.0 1.7 2.6 2 0 0 2 2 2 2 HYR domain IgGFc_binding PF17517.2 PIK36168.1 - 2.2e-41 142.0 5.8 4.4e-41 141.1 5.8 1.4 1 0 0 1 1 1 1 IgGFc binding protein HYR PF02494.16 PIK36168.1 - 1.7e-35 121.2 9.3 1.3e-17 63.9 2.4 2.6 2 0 0 2 2 2 2 HYR domain HYR PF02494.16 PIK36169.1 - 8.1e-31 106.2 3.7 2e-17 63.2 0.4 2.9 3 0 0 3 3 3 2 HYR domain IgGFc_binding PF17517.2 PIK36169.1 - 1.3e-29 103.5 2.1 1.8e-29 103.0 2.1 1.2 1 0 0 1 1 1 1 IgGFc binding protein MFS_1 PF07690.16 PIK36171.1 - 2e-05 23.7 7.8 3.5e-05 22.9 7.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily FxsA PF04186.13 PIK36171.1 - 0.13 12.4 2.5 0.16 12.1 0.1 2.1 1 1 1 2 2 2 0 FxsA cytoplasmic membrane protein LapA_dom PF06305.11 PIK36171.1 - 0.51 10.2 0.1 0.51 10.2 0.1 2.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF1601 PF07671.11 PIK36173.1 - 0.053 13.4 0.2 0.099 12.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1601) Pkinase_Tyr PF07714.17 PIK36174.1 - 4e-50 170.5 0.2 9.9e-36 123.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK36174.1 - 1.4e-20 73.8 0.0 1.2e-12 47.7 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Glu_cyclase_2 PF05096.12 PIK36174.1 - 0.021 14.3 0.0 0.042 13.3 0.0 1.5 2 0 0 2 2 2 0 Glutamine cyclotransferase Pterin_4a PF01329.19 PIK36174.1 - 0.17 12.1 0.1 0.83 9.9 0.0 1.9 2 0 0 2 2 2 0 Pterin 4 alpha carbinolamine dehydratase PKD_channel PF08016.12 PIK36176.1 - 1.2e-74 251.5 6.4 2.6e-74 250.4 6.4 1.6 1 0 0 1 1 1 1 Polycystin cation channel 7tm_2 PF00002.24 PIK36177.1 - 1.3e-56 191.7 20.3 1.3e-56 191.7 20.3 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK36177.1 - 4.4e-15 55.7 2.8 1e-14 54.6 1.9 2.1 2 0 0 2 2 2 1 Hormone receptor domain Vps36-NZF-N PF16988.5 PIK36177.1 - 0.13 11.6 1.0 4 6.9 0.0 2.4 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Ig_2 PF13895.6 PIK36178.1 - 3.8e-08 33.5 0.2 5.9e-08 32.9 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK36178.1 - 0.00022 21.8 0.4 0.00046 20.7 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK36178.1 - 0.0018 18.4 0.3 0.02 15.1 0.3 2.1 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK36178.1 - 0.0041 17.2 0.1 0.035 14.2 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 PIK36178.1 - 0.0079 16.4 0.3 0.075 13.2 0.3 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK36178.1 - 0.028 14.7 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain DUF4948 PF16306.5 PIK36178.1 - 0.12 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4948) fn3 PF00041.21 PIK36179.1 - 2.4e-07 31.0 0.0 4.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DHC_N2 PF08393.13 PIK36181.1 - 4.1e-25 88.7 0.3 4.1e-25 88.7 0.3 2.2 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Pro_sub2 PF18513.1 PIK36181.1 - 0.017 15.3 1.4 0.11 12.7 0.1 2.7 3 0 0 3 3 3 0 Prodomain subtilisin 2 FAS_I_H PF18314.1 PIK36181.1 - 0.032 13.8 0.0 0.097 12.3 0.0 1.8 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain Csm2_III-A PF03750.13 PIK36181.1 - 0.9 10.4 3.3 1.6 9.6 0.1 3.0 4 0 0 4 4 4 0 Csm2 Type III-A p450 PF00067.22 PIK36183.1 - 9.1e-89 298.3 0.0 1.2e-88 297.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SDF PF00375.18 PIK36184.1 - 6.1e-126 420.6 29.4 5.1e-93 312.2 19.9 2.1 2 0 0 2 2 2 2 Sodium:dicarboxylate symporter family 7tm_2 PF00002.24 PIK36185.1 - 2.9e-58 197.1 20.6 4.3e-58 196.5 20.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 PIK36185.1 - 2.5e-19 69.5 1.3 4.3e-19 68.8 1.3 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 PIK36185.1 - 1.8e-17 63.6 6.2 3.9e-17 62.5 6.2 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK36185.1 - 4.2e-05 22.8 19.1 6.2e-05 22.3 19.1 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor CrgA PF06781.12 PIK36185.1 - 0.015 15.3 0.9 0.043 13.9 0.9 1.7 1 0 0 1 1 1 0 Cell division protein CrgA RL11D PF11088.8 PIK36185.1 - 0.04 14.2 1.5 0.087 13.1 1.5 1.5 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 DUF1230 PF06799.11 PIK36185.1 - 0.16 12.1 1.3 0.43 10.7 1.3 1.7 1 0 0 1 1 1 0 Conserved in the green lineage and diatoms 27 SirB PF04247.12 PIK36185.1 - 4.4 7.4 11.3 5.5 7.1 1.3 2.4 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB Gal_Lectin PF02140.18 PIK36186.1 - 1e-21 77.1 1.6 5.1e-21 74.9 0.1 2.8 3 0 0 3 3 3 1 Galactose binding lectin domain HRM PF02793.22 PIK36186.1 - 6e-07 29.7 1.8 6e-07 29.7 1.8 2.7 3 1 0 3 3 3 1 Hormone receptor domain Pkinase PF00069.25 PIK36187.1 - 2.5e-19 69.7 0.2 3e-19 69.4 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36187.1 - 5.4e-13 48.8 0.1 6.7e-13 48.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK36187.1 - 3.1e-08 33.3 0.0 3.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like EGF_CA PF07645.15 PIK36188.1 - 4.1e-24 84.5 83.9 8.1e-08 32.3 8.7 7.0 6 1 0 6 6 6 4 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK36188.1 - 8.8e-10 38.7 69.5 3.7e-05 23.9 6.0 7.2 5 2 1 6 6 6 6 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK36188.1 - 4.3e-09 36.1 46.5 0.00014 21.7 0.6 7.5 7 0 0 7 7 7 6 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK36188.1 - 3.9e-05 23.7 70.2 0.00014 21.9 5.5 7.5 7 1 0 7 7 7 5 EGF domain Collagen PF01391.18 PIK36188.1 - 0.00086 19.0 5.4 0.0019 17.9 5.4 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) C2 PF00168.30 PIK36189.1 - 9.1e-36 122.3 1.1 4.4e-18 65.5 0.3 2.1 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 PIK36189.1 - 0.011 15.3 1.7 1.8 8.1 0.1 2.5 2 1 0 2 2 2 0 CEP76 C2 domain Peptidase_M13_N PF05649.13 PIK36190.1 - 1.2e-97 328.1 0.0 1.5e-97 327.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK36190.1 - 2.5e-45 154.6 1.3 5e-45 153.6 1.3 1.5 1 0 0 1 1 1 1 Peptidase family M13 zf-RING_2 PF13639.6 PIK36191.1 - 7.8e-13 48.5 8.5 2.8e-12 46.8 8.5 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK36191.1 - 6.4e-08 32.3 4.8 1.5e-07 31.1 4.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK36191.1 - 2.6e-07 30.4 8.4 7.8e-07 28.8 8.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK36191.1 - 8.6e-07 28.6 5.7 8.6e-07 28.6 5.7 2.5 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 PIK36191.1 - 5.3e-06 26.6 7.7 5.3e-06 26.6 7.7 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK36191.1 - 7.5e-06 25.7 7.6 2e-05 24.3 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK36191.1 - 2.5e-05 24.1 5.5 2.5e-05 24.1 5.5 2.1 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK36191.1 - 3.6e-05 23.7 4.6 0.00013 21.9 4.6 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK36191.1 - 0.00041 20.1 5.3 0.00041 20.1 5.3 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 PIK36191.1 - 0.0064 16.5 2.0 0.0089 16.1 0.6 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 PIK36191.1 - 0.0087 15.7 4.3 0.026 14.2 4.3 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 PIK36191.1 - 0.13 12.3 1.9 0.41 10.7 1.9 1.9 1 0 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 PIK36191.1 - 0.75 10.0 4.7 2.2 8.5 4.7 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 PIK36191.1 - 1.9 8.7 8.2 7.2 6.8 8.2 2.1 1 1 1 2 2 2 0 RING-variant domain Acyl-CoA_dh_1 PF00441.24 PIK36192.1 - 2.1e-40 138.4 1.3 3.1e-40 137.8 1.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK36192.1 - 9.5e-26 89.8 0.0 1.9e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK36192.1 - 6.4e-21 75.1 0.0 1.4e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK36192.1 - 4.3e-07 30.3 0.1 8.5e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK36193.1 - 2.4e-32 111.9 0.0 3.4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK36193.1 - 2.9e-26 91.5 0.0 4e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 PIK36193.1 - 0.0013 19.2 0.0 0.0023 18.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal CBM_X2 PF03442.14 PIK36193.1 - 0.054 13.6 0.0 0.089 12.9 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain X2 HpaB_N PF11794.8 PIK36193.1 - 0.19 11.4 0.0 0.6 9.7 0.0 1.8 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 PIK36194.1 - 2.8e-42 144.4 0.5 3.9e-42 144.0 0.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK36194.1 - 4.4e-32 111.1 0.0 9.9e-32 110.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK36194.1 - 6.5e-26 90.4 0.0 1.1e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK36194.1 - 1.5e-09 38.2 0.0 2.3e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 PIK36194.1 - 0.0021 18.6 0.0 0.0048 17.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal CBM_X2 PF03442.14 PIK36194.1 - 0.094 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain X2 Acyl-CoA_dh_1 PF00441.24 PIK36195.1 - 2.7e-40 138.0 0.7 4.7e-40 137.2 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK36195.1 - 5.8e-27 93.7 0.0 1.1e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK36195.1 - 3.9e-10 40.4 0.0 9.6e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK36195.1 - 1.4e-07 31.9 0.0 2.7e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 PIK36195.1 - 0.025 14.2 0.2 0.056 13.1 0.0 1.7 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_ox_N PF14749.6 PIK36195.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal PRKCSH PF07915.13 PIK36196.1 - 7.6e-15 55.7 1.9 7.6e-15 55.7 1.9 3.7 4 0 0 4 4 4 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 PIK36196.1 - 6.7e-08 32.4 0.2 3.3e-07 30.1 0.2 2.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF4131 PF13567.6 PIK36197.1 - 0.16 11.6 0.0 0.38 10.4 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) EGF_CA PF07645.15 PIK36198.1 - 1.2e-22 79.8 96.3 6.1e-10 39.1 3.9 7.6 5 2 2 7 7 7 4 Calcium-binding EGF domain cEGF PF12662.7 PIK36198.1 - 2.8e-14 52.7 48.7 2.3e-06 27.4 1.1 7.2 7 0 0 7 7 7 4 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK36198.1 - 1.9e-08 34.4 77.5 2.5e-05 24.4 8.7 7.6 6 2 0 6 6 6 5 EGF domain FXa_inhibition PF14670.6 PIK36198.1 - 5.2e-07 29.8 81.7 0.0019 18.4 9.7 7.6 3 1 3 7 7 7 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK36198.1 - 2.8e-06 27.5 80.3 0.0059 16.9 5.6 8.3 5 3 2 7 7 7 4 EGF-like domain hEGF PF12661.7 PIK36198.1 - 0.0043 17.6 18.1 0.014 16.0 2.3 10.5 11 2 0 11 11 11 4 Human growth factor-like EGF ETRAMP PF09716.10 PIK36198.1 - 5 7.3 6.8 11 6.1 6.8 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Ig_3 PF13927.6 PIK36199.1 - 0.019 15.6 0.1 2.3 8.9 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK36200.1 - 3e-22 79.0 0.9 6.7e-05 23.4 0.1 4.3 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 PIK36200.1 - 7.7e-14 51.5 0.2 0.0069 16.4 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36200.1 - 4.2e-13 49.4 0.6 0.0067 16.7 0.0 4.3 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK36200.1 - 2.3e-12 46.9 1.5 0.1 12.8 0.1 4.6 4 1 1 5 5 5 4 Immunoglobulin domain V-set PF07686.17 PIK36200.1 - 3.2e-07 30.5 0.6 0.45 10.7 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK36200.1 - 2.5e-05 24.2 0.1 0.71 10.0 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK36201.1 - 4.2e-05 23.7 0.3 0.00039 20.6 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain DUF2615 PF11027.8 PIK36201.1 - 0.00026 21.1 0.0 0.00069 19.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) Pilin_N PF07790.11 PIK36201.1 - 0.018 15.9 0.2 0.05 14.5 0.2 1.7 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal EptA_B_N PF08019.12 PIK36201.1 - 0.033 14.1 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 Phosphoethanolamine transferase EptA/EptB ECSCR PF15820.5 PIK36201.1 - 0.095 12.5 0.3 0.34 10.7 0.1 2.0 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator SpoIIIAH PF12685.7 PIK36201.1 - 3.8 7.3 7.7 12 5.6 7.7 1.8 1 1 0 1 1 1 0 SpoIIIAH-like protein SLX9 PF15341.6 PIK36202.1 - 2.2e-21 76.6 14.6 2.2e-21 76.6 14.6 1.8 1 1 1 2 2 2 1 Ribosome biogenesis protein SLX9 CTNNB1_binding PF08347.11 PIK36202.1 - 0.045 13.9 1.6 0.084 13.0 1.6 1.4 1 0 0 1 1 1 0 N-terminal CTNNB1 binding DDHD PF02862.17 PIK36202.1 - 4.9 7.2 6.9 7.2 6.7 6.5 1.3 1 1 0 1 1 1 0 DDHD domain Adaptin_binding PF10199.9 PIK36205.1 - 0.029 15.0 1.1 0.041 14.5 1.1 1.4 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Pkinase PF00069.25 PIK36206.1 - 1.7e-69 234.2 0.0 2e-69 233.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36206.1 - 2.4e-32 112.3 0.0 3.6e-32 111.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK36206.1 - 0.00039 19.8 0.5 0.0006 19.2 0.5 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK36206.1 - 0.0013 17.6 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK36206.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 PIK36206.1 - 0.015 14.4 0.5 0.028 13.5 0.5 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 PIK36206.1 - 0.048 13.2 0.3 0.1 12.1 0.2 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 PIK36206.1 - 0.05 13.5 0.0 0.35 10.8 0.3 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family 7tm_1 PF00001.21 PIK36207.1 - 9.4e-35 120.2 6.7 1.2e-34 119.8 6.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK36207.1 - 9e-06 25.2 7.1 1.6e-05 24.4 7.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK36207.1 - 1.7e-05 24.3 6.3 9.4e-05 21.8 6.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw RT_RNaseH_2 PF17919.1 PIK36208.1 - 4e-38 129.5 0.0 6.1e-38 128.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36208.1 - 1e-35 122.2 0.0 1.8e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Ran_BP1 PF00638.18 PIK36209.1 - 1e-48 164.6 0.6 1.4e-48 164.2 0.6 1.2 1 0 0 1 1 1 1 RanBP1 domain Lig_C PF18330.1 PIK36209.1 - 0.014 15.4 0.5 0.028 14.4 0.2 1.6 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region Pex26 PF07163.12 PIK36209.1 - 0.06 12.6 0.9 0.081 12.2 0.9 1.1 1 0 0 1 1 1 0 Pex26 protein Fer4 PF00037.27 PIK36210.1 - 3.3e-14 52.0 17.5 1.4e-08 34.2 4.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 PIK36210.1 - 8.4e-13 48.7 10.5 1.4e-12 48.0 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 PIK36210.1 - 4.7e-11 43.5 6.2 3.6e-05 24.6 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 PIK36210.1 - 2.7e-10 40.2 3.1 0.00015 21.8 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 PIK36210.1 - 8.2e-09 35.4 20.9 3.5e-06 27.0 12.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 PIK36210.1 - 1.2e-08 35.0 10.3 2.1e-08 34.2 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 PIK36210.1 - 2.4e-07 30.5 17.8 0.00032 20.6 5.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 PIK36210.1 - 4.6e-07 30.2 19.4 0.00021 21.6 11.7 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 PIK36210.1 - 8.8e-07 28.7 12.1 0.0022 18.0 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 PIK36210.1 - 5.2e-06 26.6 11.4 0.00028 21.1 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 PIK36210.1 - 0.00036 21.0 11.7 0.035 14.7 12.7 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 PIK36210.1 - 0.0059 16.8 5.7 0.61 10.4 0.5 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.6 PIK36210.1 - 0.011 16.3 14.7 0.58 10.7 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 PIK36210.1 - 0.028 14.6 8.7 0.89 9.8 1.5 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 PIK36210.1 - 0.13 13.2 16.3 0.29 12.2 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 PIK36210.1 - 0.18 11.9 5.8 1.1 9.5 0.6 2.4 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 PIK36210.1 - 0.5 11.2 11.8 2.3 9.1 1.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain DUF1296 PF06972.11 PIK36211.1 - 0.00049 20.2 1.2 0.0033 17.5 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1296) IL4 PF00727.18 PIK36211.1 - 0.07 13.4 0.1 0.2 11.9 0.1 1.8 1 0 0 1 1 1 0 Interleukin 4 Ig_3 PF13927.6 PIK36212.1 - 6.9e-05 23.4 0.7 1.2 9.8 0.2 4.2 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK36212.1 - 0.0005 20.2 0.2 0.34 11.1 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK36212.1 - 0.019 15.1 0.1 0.21 11.8 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Vta1_C PF18097.1 PIK36212.1 - 0.042 13.5 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 Vta1 C-terminal domain I-set PF07679.16 PIK36212.1 - 0.091 12.8 0.1 9.6 6.4 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain UBA_4 PF14555.6 PIK36213.1 - 0.098 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain Amino_oxidase PF01593.24 PIK36214.1 - 1.9e-36 126.4 0.0 2.5e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK36214.1 - 0.0098 16.1 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RT_RNaseH_2 PF17919.1 PIK36215.1 - 1.7e-16 60.0 0.1 6.9e-16 58.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36215.1 - 1e-13 51.3 0.2 4.9e-13 49.1 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK36215.1 - 5.4e-05 23.4 0.0 0.00088 19.5 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK36216.1 - 1.1e-25 90.1 0.1 2.5e-25 89.0 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36216.1 - 2.5e-19 69.1 1.4 5.2e-19 68.1 1.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK36216.1 - 4.7e-05 23.1 0.1 0.00018 21.2 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK36216.1 - 0.00016 21.8 0.7 0.00039 20.6 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger DUF2866 PF11065.8 PIK36217.1 - 4.6 7.4 5.0 0.6 10.2 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2866) gag-asp_proteas PF13975.6 PIK36218.1 - 7.7e-07 29.6 0.4 3.3e-06 27.6 0.0 2.3 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK36218.1 - 0.00035 21.2 0.0 0.0012 19.5 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK36218.1 - 0.013 15.6 3.3 0.42 10.8 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.20 PIK36218.1 - 0.07 13.4 0.1 0.29 11.5 0.1 2.1 1 1 0 1 1 1 0 Retroviral aspartyl protease DUF515 PF04415.12 PIK36218.1 - 0.2 10.0 1.2 0.39 9.1 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) zf-CCHC_5 PF14787.6 PIK36218.1 - 0.4 10.4 6.9 0.22 11.3 2.8 2.2 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger PolC_DP2 PF03833.13 PIK36218.1 - 0.52 8.1 5.8 0.92 7.3 5.8 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 EamA PF00892.20 PIK36219.1 - 4.3e-14 52.9 17.6 5.3e-14 52.5 17.6 1.1 1 0 0 1 1 1 1 EamA-like transporter family PUNUT PF16913.5 PIK36219.1 - 0.17 11.1 13.8 0.024 13.9 4.3 2.1 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport DUF3483 PF11982.8 PIK36219.1 - 0.32 10.6 3.1 0.23 11.0 1.7 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3483) DUF2975 PF11188.8 PIK36219.1 - 2.6 7.9 13.5 3.1 7.7 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) DUF4624 PF15417.6 PIK36221.1 - 0.078 12.8 0.2 2.7 7.8 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4624) Ldl_recept_b PF00058.17 PIK36222.1 - 3.6e-22 78.6 9.5 0.00015 22.1 0.4 9.2 10 0 0 10 10 10 4 Low-density lipoprotein receptor repeat class B DUF5050 PF16472.5 PIK36222.1 - 1.1e-06 28.1 0.0 0.0005 19.4 0.0 3.7 3 1 1 4 4 4 2 Domain of unknown function (DUF5050) EGF PF00008.27 PIK36222.1 - 0.00015 22.0 18.8 0.026 14.8 6.1 2.9 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 PIK36222.1 - 0.016 15.4 6.5 0.016 15.4 6.5 3.6 4 0 0 4 4 4 0 EGF domain EGF_MSP1_1 PF12946.7 PIK36222.1 - 0.047 13.7 6.4 0.12 12.4 6.4 1.7 1 0 0 1 1 1 0 MSP1 EGF domain 1 HS1_rep PF02218.15 PIK36222.1 - 0.086 13.2 0.8 0.19 12.1 0.2 1.9 2 0 0 2 2 2 0 Repeat in HS1/Cortactin hEGF PF12661.7 PIK36222.1 - 0.095 13.4 15.4 0.037 14.7 5.8 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK36222.1 - 0.88 9.9 5.2 2.6 8.4 5.2 1.9 1 0 0 1 1 1 0 Pvs28 EGF domain Prefoldin_2 PF01920.20 PIK36223.1 - 4.5e-07 29.8 1.4 5.3e-07 29.5 1.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Herpes_UL6 PF01763.16 PIK36223.1 - 0.0096 14.5 0.3 0.0099 14.4 0.3 1.0 1 0 0 1 1 1 1 Herpesvirus UL6 like Pex14_N PF04695.13 PIK36224.1 - 8.3 7.0 8.3 9.4 6.9 8.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Baculo_11_kDa PF06143.11 PIK36225.1 - 0.073 12.7 0.6 0.19 11.4 0.6 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF5316 PF17247.2 PIK36225.1 - 0.11 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5316) zf-AN1 PF01428.16 PIK36226.1 - 3.4e-09 36.7 10.4 6.9e-09 35.7 10.4 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger DUF5009 PF16401.5 PIK36227.1 - 1.8e-07 31.0 0.6 1.8e-07 31.0 0.6 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF5009) DUF1624 PF07786.12 PIK36227.1 - 1.9e-06 27.6 1.1 1.9e-06 27.6 1.1 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1624) DUF4051 PF13260.6 PIK36227.1 - 2.1 8.2 4.6 5.8 6.7 4.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) SAM_1 PF00536.30 PIK36228.1 - 2.7e-12 46.9 0.0 5.5e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK36228.1 - 4e-10 39.7 0.0 9.4e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_1 PF00013.29 PIK36228.1 - 4.4e-08 32.8 0.0 1.7e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 KH domain KH_10 PF17905.1 PIK36228.1 - 0.00032 21.1 0.1 0.00072 19.9 0.1 1.6 1 0 0 1 1 1 1 GLD-3 KH domain 5 KH_1 PF00013.29 PIK36229.1 - 5.9e-15 54.8 2.7 1.9e-13 50.0 1.2 2.4 2 0 0 2 2 2 2 KH domain DUF3446 PF11928.8 PIK36229.1 - 0.2 12.0 11.9 0.58 10.5 11.9 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain TraG_N PF07916.11 PIK36229.1 - 0.25 10.2 8.5 0.39 9.5 8.5 1.4 1 0 0 1 1 1 0 TraG-like protein, N-terminal region 7tm_1 PF00001.21 PIK36230.1 - 3.6e-41 141.2 23.4 4.5e-41 140.9 23.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36230.1 - 3.8e-14 53.0 16.6 3.8e-14 53.0 16.6 1.6 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK36230.1 - 8.3e-14 51.6 20.2 1.1e-13 51.2 20.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Flavi_NS4B PF01349.17 PIK36230.1 - 0.31 10.4 4.4 0.44 9.9 0.9 2.2 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4B CPSF73-100_C PF11718.8 PIK36231.1 - 2.4e-30 105.7 0.1 3e-30 105.4 0.1 1.1 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DUF1657 PF07870.11 PIK36231.1 - 0.057 13.3 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) Thioredoxin_13 PF18401.1 PIK36233.1 - 1.9e-36 125.0 0.1 2.9e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_14 PF18402.1 PIK36233.1 - 1e-06 28.9 0.1 0.0015 18.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_15 PF18403.1 PIK36233.1 - 0.048 13.6 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain SOUL PF04832.12 PIK36234.1 - 3.4e-19 69.7 0.4 3.9e-19 69.5 0.4 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein Ependymin PF00811.18 PIK36234.1 - 0.016 15.5 0.2 0.073 13.3 0.2 1.9 2 0 0 2 2 2 0 Ependymin PHM7_ext PF12621.8 PIK36234.1 - 0.096 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter Ras PF00071.22 PIK36235.1 - 3.4e-31 108.0 0.2 3.9e-31 107.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK36235.1 - 6.3e-17 61.9 0.0 7.4e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK36235.1 - 0.00061 19.3 0.0 0.00073 19.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3568 PF12092.8 PIK36235.1 - 0.048 13.7 0.1 0.058 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) AlaDh_PNT_C PF01262.21 PIK36235.1 - 0.072 12.4 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MMR_HSR1 PF01926.23 PIK36235.1 - 0.076 13.1 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Tetraspanin PF00335.20 PIK36236.1 - 9.1e-39 133.5 9.2 1.1e-38 133.3 9.2 1.0 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 PIK36236.1 - 0.0013 18.9 0.9 0.0013 18.9 0.9 2.1 2 0 0 2 2 2 1 CD20-like family DUF4199 PF13858.6 PIK36236.1 - 2.6 8.4 12.4 0.18 12.2 5.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF2207 PF09972.9 PIK36236.1 - 6.9 5.3 8.0 1.1 7.9 4.2 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) zf-C2H2 PF00096.26 PIK36237.1 - 0.0012 19.2 3.1 0.018 15.4 1.0 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-TRAF PF02176.18 PIK36237.1 - 0.048 14.4 6.5 0.19 12.4 0.7 2.8 1 1 1 2 2 2 0 TRAF-type zinc finger FOXP-CC PF16159.5 PIK36237.1 - 0.68 10.6 11.0 0.18 12.5 0.9 3.2 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 PIK36237.1 - 0.78 10.8 6.5 1.5 9.9 1.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger CHORD PF04968.12 PIK36237.1 - 3.5 8.4 7.9 22 5.9 0.2 2.9 2 0 0 2 2 2 0 CHORD DUF1754 PF08555.10 PIK36238.1 - 5.1e-08 33.6 13.7 2.5e-06 28.2 13.7 2.0 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) F5_F8_type_C PF00754.25 PIK36239.1 - 2.7e-06 27.5 0.0 3.8e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain ANAPC10 PF03256.16 PIK36239.1 - 0.00086 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Sad1_UNC PF07738.13 PIK36239.1 - 0.042 13.9 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal Peptidase_A17 PF05380.13 PIK36240.1 - 0.0025 17.8 0.0 0.0044 17.1 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase zf-C2H2 PF00096.26 PIK36242.1 - 7.2e-05 23.0 5.5 0.055 14.0 1.0 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 PIK36242.1 - 0.00014 22.4 1.7 0.0067 17.0 0.1 2.5 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 PIK36242.1 - 0.0014 19.3 1.4 0.52 11.3 0.0 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger EpoR_lig-bind PF09067.10 PIK36242.1 - 0.002 18.3 0.1 0.0042 17.3 0.1 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding zf-H2C2_2 PF13465.6 PIK36242.1 - 0.003 17.9 1.4 0.26 11.8 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_aberr PF17017.5 PIK36242.1 - 0.21 11.7 1.8 7.1 6.7 0.2 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger PDZ PF00595.24 PIK36244.1 - 3.4e-20 72.2 0.1 3.9e-20 72.0 0.1 1.0 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK36244.1 - 4.7e-11 42.4 0.0 6.2e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK36244.1 - 7.9e-09 35.7 0.0 9.5e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Dimer_Tnp_hAT PF05699.14 PIK36245.1 - 3.2e-10 39.7 0.0 5.1e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region GDP_Man_Dehyd PF16363.5 PIK36246.1 - 3.9e-10 39.6 0.0 5.5e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK36246.1 - 1.3e-09 37.9 0.0 1.9e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK36246.1 - 4.2e-05 22.7 0.0 6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 PIK36246.1 - 0.003 16.8 0.0 0.0048 16.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 PIK36246.1 - 0.0031 17.0 0.0 0.012 15.1 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK36246.1 - 0.004 16.3 0.0 0.021 13.9 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 PIK36246.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding UXS1_N PF11803.8 PIK36246.1 - 0.016 15.6 0.1 0.028 14.8 0.1 1.4 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal NAD_binding_7 PF13241.6 PIK36246.1 - 0.046 14.2 0.0 0.081 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 PIK36246.1 - 0.054 13.8 0.0 0.088 13.1 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Glyco_transf_4 PF13439.6 PIK36246.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 KR PF08659.10 PIK36246.1 - 0.07 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 KR domain NmrA PF05368.13 PIK36246.1 - 0.13 11.8 0.1 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family PCRF PF03462.18 PIK36247.1 - 0.0085 16.0 0.3 0.012 15.5 0.3 1.2 1 0 0 1 1 1 1 PCRF domain TetR_C_19 PF17924.1 PIK36247.1 - 0.13 12.9 2.2 0.16 12.6 0.5 1.9 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SET PF00856.28 PIK36248.1 - 3.3e-07 30.9 0.0 3.3e-07 30.9 0.0 2.6 4 1 0 4 4 4 1 SET domain NDK PF00334.19 PIK36248.1 - 0.15 12.0 0.0 0.46 10.5 0.0 1.7 1 0 0 1 1 1 0 Nucleoside diphosphate kinase GDP_Man_Dehyd PF16363.5 PIK36249.1 - 9.8e-24 84.3 0.2 3e-23 82.8 0.2 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK36249.1 - 2.9e-21 76.0 0.0 3.8e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NACHT PF05729.12 PIK36251.1 - 3.6e-15 56.3 0.0 5.7e-09 36.1 0.0 2.5 1 1 1 2 2 2 2 NACHT domain ig PF00047.25 PIK36251.1 - 1.3e-06 28.5 1.4 0.049 13.8 0.2 3.3 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK36251.1 - 0.00035 20.7 1.2 0.48 10.6 0.0 3.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain AAA_22 PF13401.6 PIK36251.1 - 0.015 15.6 0.0 0.051 13.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 PIK36251.1 - 0.024 14.5 0.0 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 PIK36251.1 - 0.037 13.3 0.0 0.082 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ig_2 PF13895.6 PIK36251.1 - 0.053 13.9 5.7 1.9 8.9 0.5 4.4 3 2 0 3 3 3 0 Immunoglobulin domain ATPase PF06745.13 PIK36251.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC C2-set_2 PF08205.12 PIK36251.1 - 0.084 13.0 0.1 0.32 11.1 0.1 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain AAA_16 PF13191.6 PIK36251.1 - 0.089 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Ig_3 PF13927.6 PIK36251.1 - 0.14 12.8 9.4 1 10.0 0.9 4.3 5 0 0 5 5 5 0 Immunoglobulin domain SRCR PF00530.18 PIK36252.1 - 2.4e-26 92.2 0.4 6.1e-26 90.9 0.1 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain HYR PF02494.16 PIK36252.1 - 1.6e-11 44.4 7.6 1e-08 35.4 0.6 2.7 3 0 0 3 3 3 2 HYR domain SRCR_2 PF15494.6 PIK36252.1 - 0.00026 21.5 0.0 0.00061 20.3 0.0 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain TAN PF11640.8 PIK36254.1 - 7.7e-15 55.3 1.8 1.4e-13 51.2 0.0 3.1 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair AIPR PF10592.9 PIK36254.1 - 0.099 12.3 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 AIPR protein DUF4083 PF13314.6 PIK36256.1 - 8.3e-05 22.5 1.5 0.00019 21.3 1.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4083) C2-set_2 PF08205.12 PIK36256.1 - 0.0089 16.1 0.1 0.037 14.1 0.0 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK36256.1 - 0.042 14.0 0.1 2.4 8.4 0.0 3.2 3 1 1 4 4 4 0 Immunoglobulin domain NACHT PF05729.12 PIK36257.1 - 1.4e-13 51.1 0.0 5.1e-13 49.3 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK36257.1 - 9.1e-07 29.2 0.0 5e-06 26.8 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK36257.1 - 0.00067 20.1 0.0 0.0075 16.7 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain NLRC4_HD2 PF17776.1 PIK36257.1 - 0.16 12.5 5.0 0.14 12.7 1.4 2.8 2 1 0 2 2 2 0 NLRC4 helical domain HD2 V-set PF07686.17 PIK36258.1 - 0.00023 21.3 1.4 0.021 15.0 0.2 2.9 2 1 1 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK36258.1 - 0.00065 19.7 0.7 0.003 17.6 0.2 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Dynein_light PF01221.18 PIK36259.1 - 0.18 12.1 0.9 0.24 11.8 0.9 1.2 1 0 0 1 1 1 0 Dynein light chain type 1 dsrm PF00035.26 PIK36260.1 - 6.6e-14 52.4 0.6 3.9e-11 43.5 0.2 2.3 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK36260.1 - 0.019 15.2 1.3 4.6 7.6 1.5 3.1 2 1 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 7tm_1 PF00001.21 PIK36262.1 - 3.2e-34 118.5 3.6 4e-34 118.1 3.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 PIK36262.1 - 0.0016 18.4 1.6 0.005 16.9 1.6 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term FA_desaturase PF00487.24 PIK36262.1 - 1.2 8.9 0.0 1.2 8.9 0.0 3.0 2 1 1 3 3 3 0 Fatty acid desaturase PID PF00640.23 PIK36263.1 - 3.8e-06 27.0 0.1 9.9e-06 25.6 0.1 1.7 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 PIK36263.1 - 4.2e-06 26.8 0.0 6.3e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PSP PF04046.16 PIK36264.1 - 1.9e-17 62.9 0.1 4.2e-17 61.7 0.1 1.6 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.23 PIK36264.1 - 0.00014 21.8 1.2 0.00021 21.2 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle Ntox16 PF15523.6 PIK36264.1 - 0.037 14.2 0.3 0.074 13.3 0.3 1.5 1 0 0 1 1 1 0 Novel toxin 16 Amino_oxidase PF01593.24 PIK36265.1 - 9.1e-35 120.8 0.0 1.1e-34 120.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase PK PF00224.21 PIK36265.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain DUF2043 PF09740.9 PIK36266.1 - 8.1e-25 87.6 1.7 3.9e-23 82.1 0.0 3.9 2 2 0 2 2 2 1 Uncharacterized conserved protein (DUF2043) Dynactin_p22 PF07426.11 PIK36266.1 - 0.0034 17.3 1.1 0.0034 17.3 1.1 2.5 3 0 0 3 3 3 1 Dynactin subunit p22 RRXRR PF14239.6 PIK36266.1 - 0.0069 16.3 1.5 1.5 8.7 0.0 2.4 2 0 0 2 2 2 2 RRXRR protein GCK PF07802.11 PIK36266.1 - 0.11 12.9 3.2 0.57 10.6 0.5 2.7 2 0 0 2 2 2 0 GCK domain Topoisom_I_N PF02919.15 PIK36266.1 - 0.14 11.7 1.0 0.39 10.2 1.0 1.7 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Rsc14 PF08586.10 PIK36266.1 - 3.3 8.6 6.9 4.5 8.1 0.0 4.1 5 1 0 5 5 5 0 RSC complex, Rsc14/Ldb7 subunit DUF1411 PF07199.11 PIK36267.1 - 0.064 12.9 0.2 0.1 12.3 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1411) AsiA PF09010.10 PIK36267.1 - 0.092 12.9 0.2 0.13 12.4 0.2 1.2 1 0 0 1 1 1 0 Anti-Sigma Factor A EGF PF00008.27 PIK36269.1 - 5.2e-75 247.2 427.9 1.2e-06 28.7 9.4 27.9 28 0 0 28 28 28 22 EGF-like domain HYR PF02494.16 PIK36269.1 - 3e-54 181.3 33.7 1.1e-08 35.3 0.1 7.7 7 0 0 7 7 7 7 HYR domain hEGF PF12661.7 PIK36269.1 - 1e-24 86.2 355.9 0.0022 18.6 7.6 29.1 26 1 1 27 27 27 22 Human growth factor-like EGF DOMON PF03351.17 PIK36269.1 - 8.8e-12 45.3 0.0 2.1e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 DOMON domain Multi_ubiq PF14452.6 PIK36269.1 - 0.0077 16.5 0.1 1.3 9.3 0.0 3.3 3 0 0 3 3 3 1 Multiubiquitin Bact_lectin PF18483.1 PIK36269.1 - 0.043 13.8 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial lectin AP_endonuc_2_N PF07582.12 PIK36269.1 - 0.052 13.3 0.2 13 5.6 0.0 2.5 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus Ephrin_rec_like PF07699.13 PIK36270.1 - 4e-49 164.1 196.3 3.3e-08 33.2 4.7 13.3 6 2 6 13 13 13 11 Putative ephrin-receptor like GIY-YIG PF01541.24 PIK36270.1 - 0.00054 20.2 0.0 0.00095 19.4 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain SH2_2 PF14633.6 PIK36270.1 - 0.22 10.9 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 SH2 domain ATXN-1_C PF12547.8 PIK36270.1 - 1.8 9.0 6.5 9.6 6.6 0.1 3.3 3 0 0 3 3 3 0 Capicua transcriptional repressor modulator NCD3G PF07562.14 PIK36270.1 - 5.1 7.1 165.4 0.028 14.4 8.0 14.2 6 3 8 14 14 14 0 Nine Cysteines Domain of family 3 GPCR MORN PF02493.20 PIK36270.1 - 9 6.4 9.4 1.4e+02 2.7 0.1 4.7 4 0 0 4 4 4 0 MORN repeat EF-hand_1 PF00036.32 PIK36271.1 - 3e-06 26.4 2.0 0.00032 20.0 0.7 3.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK36271.1 - 1.1e-05 24.9 2.0 9e-05 22.1 0.2 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 PIK36271.1 - 5.3e-05 23.0 2.5 6e-05 22.8 0.7 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 PIK36271.1 - 0.00065 20.1 0.9 0.00065 20.1 0.9 2.8 1 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK36271.1 - 0.018 14.5 0.7 0.018 14.5 0.7 2.8 2 0 0 2 2 2 0 EF hand DUF4407 PF14362.6 PIK36271.1 - 0.26 10.6 12.8 0.59 9.4 11.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2937 PF11157.8 PIK36271.1 - 0.27 10.9 2.9 0.44 10.2 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2937) SPARC_Ca_bdg PF10591.9 PIK36271.1 - 1.8 8.9 8.2 3.1 8.2 6.4 2.3 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region RbsD_FucU PF05025.13 PIK36271.1 - 5.9 7.3 9.9 0.34 11.3 1.5 2.5 1 1 1 3 3 3 0 RbsD / FucU transport protein family TFR_dimer PF04253.15 PIK36271.1 - 6.6 6.9 7.6 1.4e+02 2.6 7.1 2.7 1 1 0 1 1 1 0 Transferrin receptor-like dimerisation domain LETM1 PF07766.13 PIK36272.1 - 1.6e-88 296.5 17.9 3.8e-87 292.0 6.8 2.7 3 0 0 3 3 3 2 LETM1-like protein MinC_N PF05209.13 PIK36272.1 - 0.055 13.4 0.1 3.4 7.7 0.0 2.7 2 1 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain HigB-like_toxin PF05015.13 PIK36272.1 - 0.11 12.9 0.2 3.7 8.0 0.0 2.6 2 0 0 2 2 2 0 RelE-like toxin of type II toxin-antitoxin system HigB PWWP PF00855.17 PIK36273.1 - 5.1e-18 65.3 0.1 5.1e-18 65.3 0.1 3.8 3 1 1 4 4 4 1 PWWP domain HMG_box PF00505.19 PIK36273.1 - 9.5e-07 29.1 3.1 4e-06 27.2 3.1 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box Peptidase_S41_N PF11918.8 PIK36273.1 - 0.52 10.5 4.6 1.2 9.4 1.4 2.8 2 0 0 2 2 2 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP PHD PF00628.29 PIK36274.1 - 3.5e-08 33.2 19.4 1.1e-06 28.4 7.5 2.7 3 0 0 3 3 3 2 PHD-finger Zf_RING PF16744.5 PIK36274.1 - 0.0041 17.2 15.0 0.021 14.9 2.0 2.3 2 0 0 2 2 2 2 KIAA1045 RING finger zf-HC5HC2H PF13771.6 PIK36274.1 - 0.0046 17.2 18.4 0.16 12.3 4.6 2.4 1 1 1 2 2 2 2 PHD-like zinc-binding domain zf-RING_2 PF13639.6 PIK36274.1 - 0.0078 16.5 20.1 0.011 16.0 3.1 2.7 2 1 0 2 2 2 2 Ring finger domain zf-HC5HC2H_2 PF13832.6 PIK36274.1 - 0.27 11.4 17.8 3.3 7.9 4.5 2.3 1 1 1 2 2 2 0 PHD-zinc-finger like domain zf-rbx1 PF12678.7 PIK36274.1 - 0.28 11.5 15.7 2.1 8.7 3.0 2.7 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING-like PF08746.11 PIK36274.1 - 8.1 6.8 21.9 2 8.8 2.4 3.4 3 1 0 3 3 3 0 RING-like domain PWWP PF00855.17 PIK36275.1 - 1.1e-20 73.8 0.2 1.1e-20 73.8 0.2 4.4 5 0 0 5 5 5 1 PWWP domain SET PF00856.28 PIK36275.1 - 2.9e-19 70.1 0.2 2.9e-19 70.1 0.2 4.7 3 2 1 4 4 4 1 SET domain AWS PF17907.1 PIK36275.1 - 6.8e-14 51.6 6.0 6.8e-14 51.6 6.0 5.4 7 0 0 7 7 7 1 AWS domain C5HCH PF17982.1 PIK36275.1 - 1.1e-09 38.3 9.2 1.1e-09 38.3 9.2 4.5 5 0 0 5 5 5 1 NSD Cys-His rich domain PHD PF00628.29 PIK36275.1 - 1.1e-07 31.6 10.9 1.1e-07 31.6 10.9 4.9 4 1 1 5 5 5 2 PHD-finger SBF PF01758.16 PIK36276.1 - 7e-15 55.2 7.3 7e-15 55.2 7.3 2.3 1 1 1 2 2 2 1 Sodium Bile acid symporter family ECD PF18432.1 PIK36276.1 - 0.016 15.2 0.6 0.042 13.8 0.6 1.7 1 0 0 1 1 1 0 Extracellular Cadherin domain zf-RING_UBOX PF13445.6 PIK36277.1 - 3.5e-10 39.7 7.9 1.2e-09 38.1 7.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK36277.1 - 2.2e-08 34.1 9.7 2.2e-08 34.1 9.7 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK36277.1 - 9.8e-08 31.7 9.9 9.8e-08 31.7 9.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK36277.1 - 1.1e-07 32.1 12.3 2.4e-07 30.9 8.7 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK36277.1 - 2.3e-07 30.6 6.0 2.3e-07 30.6 6.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK36277.1 - 5.9e-07 29.3 12.0 7.4e-07 28.9 9.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK36277.1 - 3.7e-06 26.8 8.1 3.6e-05 23.6 7.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK36277.1 - 4.3e-05 23.3 8.4 4.3e-05 23.3 8.4 2.8 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK36277.1 - 0.0012 18.6 6.4 0.055 13.2 4.5 2.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_6 PF14835.6 PIK36277.1 - 0.0047 16.8 2.6 0.013 15.4 2.6 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Phi-29_GP16_7 PF06720.11 PIK36277.1 - 0.041 13.7 0.4 0.1 12.4 0.4 1.7 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 U-box PF04564.15 PIK36277.1 - 0.1 12.8 0.0 0.32 11.2 0.0 1.9 1 0 0 1 1 1 0 U-box domain zf-rbx1 PF12678.7 PIK36277.1 - 1.4 9.2 7.4 7.9 6.9 7.4 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 PIK36277.1 - 3.1 7.7 7.7 12 5.8 7.8 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase_Tyr PF07714.17 PIK36278.1 - 9.4e-18 64.4 0.0 1.4e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36278.1 - 2e-14 53.6 0.0 3.3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK36278.1 - 4.9e-11 42.6 0.1 1.5e-10 41.0 0.0 1.8 2 0 0 2 2 2 1 SH2 domain ATP-synt_D PF01813.17 PIK36279.1 - 0.055 13.3 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 ATP synthase subunit D Methyltransf_25 PF13649.6 PIK36280.1 - 2.5e-06 28.1 0.0 3.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36280.1 - 8.7e-05 23.1 0.0 0.00015 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK36280.1 - 0.0014 18.2 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 PIK36280.1 - 0.0022 17.8 0.0 0.0059 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK36280.1 - 0.047 13.5 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Osmo_CC PF08946.10 PIK36280.1 - 0.097 12.9 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Neur_chan_memb PF02932.16 PIK36281.1 - 5e-05 23.5 16.0 0.00046 20.3 16.0 2.0 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK36281.1 - 0.033 13.6 0.1 0.052 13.0 0.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain Herpes_UL25 PF01499.16 PIK36281.1 - 0.13 10.7 0.6 0.2 10.1 0.6 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family Neur_chan_LBD PF02931.23 PIK36282.1 - 0.038 13.4 0.1 0.061 12.8 0.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain DUF2053 PF09767.9 PIK36282.1 - 0.1 12.8 0.0 6.3 6.9 0.0 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2053) EGF_CA PF07645.15 PIK36283.1 - 1.9e-30 104.8 101.9 5.6e-09 36.1 10.4 7.3 6 2 1 7 7 7 6 Calcium-binding EGF domain EGF PF00008.27 PIK36283.1 - 9.2e-10 38.6 88.6 0.0058 16.9 5.5 9.5 6 2 1 7 7 7 7 EGF-like domain cEGF PF12662.7 PIK36283.1 - 1.8e-07 30.9 58.0 0.0022 17.8 4.5 8.3 7 1 0 7 7 7 5 Complement Clr-like EGF-like hEGF PF12661.7 PIK36283.1 - 3.3e-06 27.5 89.8 0.011 16.3 4.7 11.0 11 0 0 11 11 11 6 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK36283.1 - 0.0003 21.0 57.1 0.031 14.6 1.0 7.5 4 2 3 7 7 7 4 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK36283.1 - 0.0011 19.2 85.9 0.22 11.8 6.5 8.2 5 2 1 6 6 6 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK36283.1 - 0.0084 16.3 87.3 0.058 13.6 6.6 9.5 5 2 2 7 7 7 5 EGF domain EGF_CA PF07645.15 PIK36284.1 - 7.2e-21 74.1 70.1 2.3e-09 37.3 9.2 5.8 4 1 1 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.7 PIK36284.1 - 8.3e-14 51.2 29.4 0.0029 17.5 0.6 6.2 5 1 0 5 5 5 5 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 PIK36284.1 - 3.4e-07 30.4 47.9 0.0016 18.7 3.7 5.7 5 0 0 5 5 5 3 Pvs28 EGF domain EGF_3 PF12947.7 PIK36284.1 - 2.8e-06 27.4 59.7 0.00012 22.1 2.6 6.1 4 2 1 5 5 5 3 EGF domain FXa_inhibition PF14670.6 PIK36284.1 - 0.00018 21.7 51.0 0.081 13.2 5.8 5.9 2 2 3 5 5 5 3 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK36284.1 - 0.0022 18.6 52.7 0.047 14.4 3.6 6.9 6 0 0 6 6 5 3 Human growth factor-like EGF EB PF01683.18 PIK36284.1 - 0.0026 18.0 3.2 0.0026 18.0 3.2 5.6 2 1 3 5 5 5 2 EB module EGF PF00008.27 PIK36284.1 - 0.018 15.3 2.4 0.018 15.3 2.4 6.4 5 1 1 6 6 6 0 EGF-like domain EGF_2 PF07974.13 PIK36284.1 - 0.034 14.5 8.1 0.034 14.5 8.1 6.2 5 0 0 5 5 5 0 EGF-like domain GnRH PF00446.17 PIK36284.1 - 0.16 12.4 46.8 29 5.4 0.5 8.6 8 0 0 8 8 8 0 Gonadotropin-releasing hormone UBZ_FAAP20 PF15750.5 PIK36284.1 - 2.2 8.3 13.1 1.5e+02 2.4 0.0 6.1 6 0 0 6 6 6 0 Ubiquitin-binding zinc-finger Gly_acyl_tr_N PF06021.11 PIK36284.1 - 3.6 7.6 6.3 45 4.1 0.1 3.6 1 1 1 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase EGF_MSP1_1 PF12946.7 PIK36284.1 - 5.5 7.1 53.8 0.2 11.7 5.1 6.9 5 1 1 6 6 6 0 MSP1 EGF domain 1 Ras PF00071.22 PIK36285.1 - 5.6e-45 152.9 0.0 7.2e-45 152.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK36285.1 - 7.1e-12 45.6 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK36285.1 - 0.00062 19.3 0.0 0.001 18.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK36285.1 - 0.01 15.4 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Tropomyosin PF00261.20 PIK36286.1 - 0.0011 18.4 14.7 0.033 13.5 8.9 2.2 2 0 0 2 2 2 2 Tropomyosin Filament PF00038.21 PIK36286.1 - 0.0015 18.1 8.8 0.064 12.8 5.8 2.0 2 0 0 2 2 2 2 Intermediate filament protein Tropomyosin_1 PF12718.7 PIK36286.1 - 0.0033 17.6 8.2 0.0033 17.6 8.2 2.2 2 0 0 2 2 2 1 Tropomyosin like UPF0449 PF15136.6 PIK36286.1 - 0.014 15.9 1.2 0.014 15.9 1.2 3.3 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 PspA_IM30 PF04012.12 PIK36286.1 - 0.02 14.5 2.0 0.02 14.5 2.0 2.9 2 1 0 3 3 3 0 PspA/IM30 family Rab5-bind PF09311.11 PIK36286.1 - 0.027 13.9 10.8 0.41 10.0 9.2 2.6 2 1 1 3 3 3 0 Rabaptin-like protein Fez1 PF06818.15 PIK36286.1 - 0.16 12.4 11.6 0.45 10.9 7.5 2.2 2 0 0 2 2 2 0 Fez1 ERM PF00769.19 PIK36286.1 - 0.16 11.7 16.3 0.17 11.7 11.1 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Tweety PF04906.13 PIK36286.1 - 0.17 10.5 0.4 0.24 10.0 0.4 1.3 1 0 0 1 1 1 0 Tweety Mod_r PF07200.13 PIK36286.1 - 0.18 11.9 14.2 0.077 13.1 9.0 2.5 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Pox_A_type_inc PF04508.12 PIK36286.1 - 0.2 11.6 4.2 3.4 7.7 1.7 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat HALZ PF02183.18 PIK36286.1 - 0.66 10.2 11.3 1.4 9.2 0.6 3.6 3 1 1 4 4 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 PIK36286.1 - 0.75 10.0 18.2 1.6 9.0 11.7 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.11 PIK36286.1 - 0.82 10.1 7.0 1.8 9.0 0.7 3.4 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Uds1 PF15456.6 PIK36286.1 - 0.92 9.7 13.8 0.14 12.4 4.0 2.7 2 1 0 2 2 2 0 Up-regulated During Septation Spc7 PF08317.11 PIK36286.1 - 0.99 8.2 15.2 0.32 9.8 9.7 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein LMBR1 PF04791.16 PIK36286.1 - 1.1 8.1 3.4 1.7 7.5 3.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 PIK36286.1 - 1.6 8.8 10.1 1.3 9.1 2.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 PIK36286.1 - 3.1 8.3 17.8 2.6 8.6 11.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 PIK36286.1 - 3.8 7.8 17.2 11 6.2 0.2 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Med21 PF11221.8 PIK36286.1 - 3.9 7.7 13.3 14 5.9 13.3 2.1 1 1 0 1 1 1 0 Subunit 21 of Mediator complex PRKG1_interact PF15898.5 PIK36286.1 - 4.7 8.2 17.0 23 5.9 12.6 2.8 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain KLRAQ PF10205.9 PIK36286.1 - 4.9 7.5 17.6 4.8 7.5 10.3 3.2 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein Fib_alpha PF08702.10 PIK36286.1 - 5.3 7.2 11.4 47 4.2 9.0 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family BST2 PF16716.5 PIK36286.1 - 5.6 7.6 16.8 3.8 8.2 3.2 3.1 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 DUF724 PF05266.14 PIK36286.1 - 5.6 6.7 12.6 3.4 7.5 7.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Cnn_1N PF07989.11 PIK36286.1 - 5.9 7.1 15.4 0.27 11.4 5.1 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 PIK36286.1 - 7.2 6.5 14.4 4.9 7.0 0.2 3.8 2 1 2 4 4 4 0 Septum formation initiator SlyX PF04102.12 PIK36286.1 - 7.5 7.2 14.2 1.2 9.9 1.6 3.8 2 1 2 4 4 4 0 SlyX Rootletin PF15035.6 PIK36287.1 - 0.0004 20.4 6.9 0.00052 20.1 6.9 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF390 PF04094.14 PIK36287.1 - 0.00064 18.2 0.7 0.00071 18.0 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF390) CENP-F_leu_zip PF10473.9 PIK36287.1 - 0.0011 18.9 8.6 0.0014 18.7 8.6 1.0 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD_2 PF14197.6 PIK36287.1 - 0.002 18.2 11.1 0.015 15.4 7.7 2.7 1 1 1 2 2 2 1 Centrosome localisation domain of PPC89 bZIP_1 PF00170.21 PIK36287.1 - 0.0039 17.3 8.0 0.042 13.9 0.4 2.5 1 1 1 2 2 2 1 bZIP transcription factor KASH_CCD PF14662.6 PIK36287.1 - 0.0062 16.4 6.2 0.0065 16.3 6.2 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 PIK36287.1 - 0.014 14.7 2.3 0.014 14.7 2.3 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 PIK36287.1 - 0.029 14.7 8.6 1.2 9.5 4.5 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 PIK36287.1 - 0.029 15.0 5.3 0.079 13.6 0.9 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 PIK36287.1 - 0.12 11.2 7.4 0.13 11.1 7.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 PIK36287.1 - 0.14 12.8 5.4 0.24 12.0 2.8 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF2968 PF11180.8 PIK36287.1 - 0.3 10.7 5.4 0.33 10.6 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Cnn_1N PF07989.11 PIK36287.1 - 0.51 10.5 7.3 3.6 7.8 6.4 2.1 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 UPF0449 PF15136.6 PIK36287.1 - 1.2 9.6 5.0 0.88 10.1 1.8 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DivIC PF04977.15 PIK36287.1 - 1.3 8.9 5.7 0.43 10.4 1.3 2.2 1 1 1 2 2 2 0 Septum formation initiator APG6_N PF17675.1 PIK36287.1 - 2.1 8.9 9.4 4.3 7.9 9.4 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF2529 PF10740.9 PIK36288.1 - 0.02 14.6 0.9 0.022 14.4 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) ZapB PF06005.12 PIK36289.1 - 0.0019 18.6 10.5 0.0019 18.6 10.5 18.2 8 4 6 14 14 14 3 Cell division protein ZapB Filament PF00038.21 PIK36289.1 - 0.002 17.8 24.4 0.002 17.8 24.4 9.2 4 3 4 9 9 9 5 Intermediate filament protein DUF3450 PF11932.8 PIK36289.1 - 0.0046 16.3 7.4 0.0046 16.3 7.4 12.4 4 3 9 13 13 13 5 Protein of unknown function (DUF3450) Esterase PF00756.20 PIK36290.1 - 0.00067 19.4 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 PIK36290.1 - 0.0041 16.8 0.1 0.014 15.0 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK36290.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 PIK36290.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase PGAP1 PF07819.13 PIK36290.1 - 0.05 13.3 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 PIK36290.1 - 0.095 13.3 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 PIK36290.1 - 0.15 11.9 0.1 0.71 9.6 0.1 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family zf-H2C2_2 PF13465.6 PIK36291.1 - 4.7e-42 140.6 123.9 5.5e-06 26.6 3.3 15.9 16 0 0 16 16 16 11 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36291.1 - 1.1e-37 126.4 144.2 6.7e-05 23.1 0.6 14.7 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36291.1 - 1.7e-23 81.2 133.1 0.014 16.1 0.6 14.9 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36291.1 - 4e-18 65.2 90.8 0.012 15.9 0.5 13.9 14 0 0 14 14 14 10 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK36291.1 - 6.8e-10 39.0 96.0 0.31 11.5 1.9 14.1 14 0 0 14 14 14 10 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK36291.1 - 8.1e-08 32.1 103.1 0.019 15.0 1.8 13.8 13 0 0 13 13 13 8 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK36291.1 - 0.012 15.9 2.3 0.012 15.9 2.3 7.7 3 3 5 8 8 8 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 PIK36291.1 - 0.058 13.5 0.3 0.058 13.5 0.3 10.3 8 3 3 11 11 11 0 Zinc ribbon domain Zn-C2H2_12 PF18112.1 PIK36291.1 - 0.52 10.8 0.0 0.52 10.8 0.0 8.1 9 0 0 9 9 9 0 Autophagy receptor zinc finger-C2H2 domain ARS2 PF04959.13 PIK36291.1 - 2 8.7 11.5 2.9 8.2 0.0 4.5 4 1 0 4 4 4 0 Arsenite-resistance protein 2 Fibrinogen_C PF00147.18 PIK36292.1 - 3.9e-46 157.6 2.6 5.2e-46 157.2 2.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Sulfotransfer_2 PF03567.14 PIK36293.1 - 1.2e-31 110.5 0.1 2.9e-31 109.3 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase family zf-TRAF PF02176.18 PIK36294.1 - 2.7e-22 79.2 19.2 2.9e-14 53.5 1.5 3.1 3 0 0 3 3 3 2 TRAF-type zinc finger TRAF6_Z2 PF18048.1 PIK36294.1 - 0.0081 16.2 9.8 0.083 13.0 0.1 4.0 4 0 0 4 4 4 2 TNF receptor-associated factor 6 zinc finger 2 Exo_endo_phos PF03372.23 PIK36297.1 - 5.5e-10 39.2 0.2 7.7e-10 38.7 0.2 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK36297.1 - 9.6e-07 28.7 0.0 2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Fibrinogen_C PF00147.18 PIK36298.1 - 8.6e-64 215.4 14.1 9.6e-64 215.2 14.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK36298.1 - 0.015 14.6 0.2 0.021 14.1 0.2 1.3 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain CFC PF09443.10 PIK36298.1 - 0.3 11.0 2.9 0.66 9.9 2.9 1.5 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) CARD PF00619.21 PIK36299.1 - 3.1e-14 52.8 0.2 3.1e-14 52.8 0.2 1.6 2 0 0 2 2 2 1 Caspase recruitment domain DUF562 PF04763.12 PIK36299.1 - 0.034 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF562) Rep_4 PF05797.11 PIK36299.1 - 0.06 12.5 0.3 0.07 12.2 0.3 1.3 1 1 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) tRNA-synt_1 PF00133.22 PIK36300.1 - 1.7e-191 637.6 0.0 2.3e-190 633.9 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 PIK36300.1 - 7.8e-35 120.1 0.0 1.8e-34 118.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 PIK36300.1 - 4.7e-16 58.5 1.9 5.7e-07 28.6 0.0 4.8 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 PIK36300.1 - 4.4e-09 36.1 0.0 1.3e-07 31.3 0.0 2.4 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 PIK36300.1 - 0.0005 20.3 4.3 0.0012 19.1 4.3 1.7 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 PIK36300.1 - 0.0057 16.0 0.0 0.046 13.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Jag_N PF14804.6 PIK36300.1 - 0.02 15.2 0.1 0.043 14.2 0.1 1.5 1 0 0 1 1 1 0 Jag N-terminus FapA PF03961.13 PIK36300.1 - 0.12 10.9 0.7 0.19 10.3 0.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ocnus PF05005.15 PIK36301.1 - 2.4e-35 120.9 0.0 2.6e-35 120.8 0.0 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) zf-H2C2_2 PF13465.6 PIK36302.1 - 4.8e-18 64.7 28.4 2e-08 34.3 1.9 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36302.1 - 3.7e-12 46.0 22.8 0.00031 21.0 2.8 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36302.1 - 2.1e-09 37.4 22.1 0.0027 18.4 2.8 3.2 3 0 0 3 3 3 3 C2H2-type zinc finger PyrI_C PF02748.15 PIK36302.1 - 2.1e-06 27.5 12.2 0.13 12.1 1.3 3.2 1 1 2 3 3 3 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK36302.1 - 8.1e-05 22.8 16.8 0.065 13.5 1.0 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK36302.1 - 0.00044 20.4 19.0 0.041 14.0 1.8 3.3 1 1 2 3 3 3 2 AN1-like Zinc finger BolA PF01722.18 PIK36302.1 - 0.00097 19.4 3.4 0.068 13.5 0.5 2.2 1 1 1 2 2 2 1 BolA-like protein zf-C2H2_6 PF13912.6 PIK36302.1 - 0.0019 18.2 19.0 0.13 12.3 1.5 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-CHCC PF10276.9 PIK36302.1 - 0.0024 17.9 10.5 0.99 9.5 0.2 3.2 3 0 0 3 3 3 2 Zinc-finger domain zf-C2HC_2 PF13913.6 PIK36302.1 - 0.0032 17.3 18.7 0.076 12.9 1.7 3.5 3 1 0 3 3 3 2 zinc-finger of a C2HC-type zf-BED PF02892.15 PIK36302.1 - 0.012 15.6 15.0 0.47 10.5 1.7 3.3 1 1 2 3 3 3 0 BED zinc finger zinc-ribbons_6 PF07191.12 PIK36302.1 - 0.015 15.3 8.6 4.5 7.3 3.7 3.0 1 1 2 3 3 3 0 zinc-ribbons zf-trcl PF13451.6 PIK36302.1 - 0.03 14.2 7.8 7.7 6.5 0.3 3.2 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-C2HE PF16278.5 PIK36302.1 - 0.033 14.6 14.5 0.58 10.6 0.2 3.2 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3850 PF12961.7 PIK36302.1 - 0.038 14.0 0.2 2.2 8.4 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3850) PriA_CRR PF18319.1 PIK36302.1 - 0.058 13.4 5.2 18 5.5 0.1 3.3 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain zf-met PF12874.7 PIK36302.1 - 0.08 13.4 16.6 0.19 12.2 0.5 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Zf_RING PF16744.5 PIK36302.1 - 0.13 12.4 10.6 1.4 9.1 0.5 3.0 1 1 2 3 3 3 0 KIAA1045 RING finger Scramblase PF03803.15 PIK36302.1 - 0.13 11.6 1.6 0.27 10.5 1.6 1.4 1 1 0 1 1 1 0 Scramblase DUF3268 PF11672.8 PIK36302.1 - 0.19 12.0 7.1 0.24 11.7 3.6 2.0 1 1 1 2 2 2 0 zinc-finger-containing domain LIM PF00412.22 PIK36302.1 - 0.22 11.8 13.9 2.4 8.5 6.5 2.9 1 1 1 2 2 2 0 LIM domain zf-Sec23_Sec24 PF04810.15 PIK36302.1 - 0.28 11.3 8.1 0.39 10.8 3.5 2.5 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger C1_1 PF00130.22 PIK36302.1 - 0.32 10.9 15.0 6.1 6.8 7.0 2.9 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-MYND PF01753.18 PIK36302.1 - 0.33 11.1 12.0 0.3 11.2 5.9 2.8 1 1 1 2 2 2 0 MYND finger zf-C2H2_2 PF12756.7 PIK36302.1 - 0.38 11.1 14.0 2.7 8.4 2.2 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 PIK36302.1 - 0.4 10.3 7.3 11 5.7 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 PIK36302.1 - 0.42 10.9 15.7 2.7 8.3 8.0 2.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 PIK36302.1 - 0.46 11.2 11.5 2.2 9.0 1.2 3.0 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 PIK36302.1 - 0.68 10.1 14.9 2 8.6 0.3 3.4 2 1 0 2 2 2 0 Zinc ribbon domain HypA PF01155.19 PIK36302.1 - 0.78 9.8 7.3 0.65 10.0 2.7 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HNH_5 PF14279.6 PIK36302.1 - 0.8 9.6 10.9 8.1 6.4 0.6 3.2 3 0 0 3 3 3 0 HNH endonuclease XPA_N PF01286.18 PIK36302.1 - 0.87 9.7 10.6 14 5.8 0.2 3.2 3 0 0 3 3 3 0 XPA protein N-terminal C1_4 PF07975.12 PIK36302.1 - 1 9.6 15.8 3.5 7.9 0.7 2.9 1 1 2 3 3 3 0 TFIIH C1-like domain Elf1 PF05129.13 PIK36302.1 - 1.4 9.0 13.8 4.3 7.4 5.7 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like FYVE PF01363.21 PIK36302.1 - 1.5 9.0 18.0 8.3 6.6 7.6 2.6 1 1 1 2 2 2 0 FYVE zinc finger HNH PF01844.23 PIK36302.1 - 1.6 9.0 10.9 4.7 7.5 0.8 3.0 3 0 0 3 3 3 0 HNH endonuclease zf-CHY PF05495.12 PIK36302.1 - 3.5 8.2 15.5 5.4 7.6 10.4 2.2 1 1 1 2 2 2 0 CHY zinc finger CpXC PF14353.6 PIK36302.1 - 4.4 7.4 8.9 2.1 8.4 0.4 2.7 1 1 2 3 3 3 0 CpXC protein Desulfoferrod_N PF06397.12 PIK36302.1 - 5.3 6.8 6.8 12 5.6 0.2 3.2 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain UBZ_FAAP20 PF15750.5 PIK36302.1 - 5.7 7.0 6.9 6 6.9 0.3 3.0 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger NPL PF17800.1 PIK36303.1 - 9.5e-13 48.6 0.1 1.8e-12 47.7 0.0 1.5 2 0 0 2 2 2 1 Nucleoplasmin-like domain Nucleoplasmin PF03066.15 PIK36303.1 - 0.088 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain RT_RNaseH PF17917.1 PIK36304.1 - 8.6e-32 109.6 0.2 5.8e-31 106.9 0.1 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK36304.1 - 1e-23 83.2 0.1 2.9e-23 81.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK36304.1 - 8.4e-23 80.8 0.0 3.4e-22 78.9 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36304.1 - 7.9e-15 54.7 3.1 3.9e-14 52.5 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK36304.1 - 4.7e-05 23.1 0.5 0.00012 21.7 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain Clathrin PF00637.20 PIK36305.1 - 2.9e-08 33.7 28.2 0.41 10.5 0.4 8.6 6 3 3 9 9 9 5 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 PIK36305.1 - 0.0023 18.2 0.1 1.5 9.1 0.0 3.9 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK36305.1 - 0.019 15.8 0.7 44 5.2 0.2 4.5 4 0 0 4 4 4 0 WD domain, G-beta repeat TPR_7 PF13176.6 PIK36305.1 - 0.048 13.7 23.5 4.7 7.5 0.1 10.1 10 3 0 10 10 10 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK36305.1 - 0.083 13.1 16.0 2.8 8.2 0.0 7.6 6 2 2 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK36305.1 - 0.14 11.9 14.0 2.3 8.0 0.2 6.9 7 0 0 7 7 7 0 TPR repeat TPR_16 PF13432.6 PIK36305.1 - 0.79 10.4 12.3 1.1 9.9 0.3 6.3 5 1 1 6 6 6 0 Tetratricopeptide repeat PPR_2 PF13041.6 PIK36305.1 - 10 6.4 6.5 42 4.4 0.1 5.3 6 0 0 6 6 6 0 PPR repeat family ANAPC4_WD40 PF12894.7 PIK36306.1 - 0.0011 19.2 0.0 0.0011 19.2 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK36306.1 - 0.0081 17.0 0.0 0.01 16.7 0.0 1.2 1 0 0 1 1 1 1 WD domain, G-beta repeat eIF2A PF08662.11 PIK36306.1 - 0.018 14.9 0.0 0.018 14.9 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Ank_4 PF13637.6 PIK36307.1 - 1.9e-53 178.2 1.4 2.8e-10 40.5 0.0 6.6 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK36307.1 - 6.5e-51 170.8 0.7 4.7e-13 49.5 0.3 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK36307.1 - 1e-38 130.8 3.9 5.8e-08 32.9 0.0 6.1 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK36307.1 - 2.5e-37 125.7 10.2 1.4e-05 25.4 0.1 7.6 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 PIK36307.1 - 3.6e-34 112.9 3.4 4.6e-05 23.5 0.0 8.0 9 0 0 9 9 9 6 Ankyrin repeat Rtf2 PF04641.12 PIK36308.1 - 1.2e-80 270.6 1.7 1.5e-80 270.4 1.7 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 PIK36308.1 - 0.0096 15.7 0.0 0.024 14.4 0.0 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 PIK36308.1 - 0.093 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TMEM65 PF10507.9 PIK36309.1 - 5.2e-45 151.9 1.1 7.4e-45 151.4 1.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 65 Integrase_H2C2 PF17921.1 PIK36310.1 - 3.2e-20 72.0 0.2 5.4e-20 71.2 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK36310.1 - 5e-05 23.4 1.3 9.3e-05 22.6 0.2 2.0 2 0 0 2 2 2 1 H2C2 zinc finger rve PF00665.26 PIK36310.1 - 0.048 13.8 0.0 0.25 11.6 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain zf-C2H2_10 PF16588.5 PIK36310.1 - 0.058 13.1 0.7 0.12 12.1 0.7 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger RVP PF00077.20 PIK36310.1 - 0.16 12.3 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK36310.1 - 2.6 8.3 4.8 2.5 8.3 1.2 2.4 2 0 0 2 2 2 0 Zinc knuckle Ras PF00071.22 PIK36311.1 - 5.8e-12 45.5 0.4 5.8e-12 45.5 0.4 1.6 2 0 0 2 2 2 1 Ras family MFS_1 PF07690.16 PIK36313.1 - 1.7e-13 50.3 1.1 2.4e-13 49.8 1.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PrgI PF12666.7 PIK36313.1 - 5.1 7.9 12.9 0.85 10.4 1.2 3.3 2 2 2 4 4 4 0 PrgI family protein DUF3487 PF11990.8 PIK36313.1 - 5.6 6.9 6.3 0.45 10.4 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) GoLoco PF02188.17 PIK36314.1 - 0.12 11.9 0.2 0.21 11.1 0.2 1.4 1 0 0 1 1 1 0 GoLoco motif RGS PF00615.19 PIK36315.1 - 2.1e-32 111.9 4.0 2.7e-32 111.5 4.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Herpes_UL3 PF03369.13 PIK36315.1 - 0.012 16.2 0.0 0.047 14.2 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus UL3 protein RVT_1 PF00078.27 PIK36316.1 - 2.1e-37 128.8 0.0 2.6e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF695 PF05117.12 PIK36317.1 - 0.28 11.4 1.0 2.3 8.4 0.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF695) PTRF_SDPR PF15237.6 PIK36317.1 - 1.1 8.8 8.6 1.6 8.3 3.8 2.9 2 1 0 2 2 2 0 PTRF/SDPR family NDT80_PhoG PF05224.12 PIK36318.1 - 0.06 13.6 2.2 6.3 7.0 0.2 2.4 2 1 0 2 2 2 0 NDT80 / PhoG like DNA-binding family zf-CCHC PF00098.23 PIK36319.1 - 1e-08 34.8 14.6 0.0002 21.3 0.2 3.7 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK36319.1 - 0.00013 21.9 12.9 0.081 12.9 0.2 3.4 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK36319.1 - 0.001 18.9 14.9 0.15 11.9 6.2 3.8 4 0 0 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK36319.1 - 0.0013 18.4 11.1 1.5 8.6 0.3 3.2 2 1 1 3 3 3 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK36319.1 - 0.0066 16.1 0.8 0.0066 16.1 0.8 2.9 2 1 1 3 3 3 1 C2H2 zinc-finger zf-CCHC_2 PF13696.6 PIK36319.1 - 0.0067 16.2 0.2 0.0067 16.2 0.2 3.8 4 0 0 4 4 4 1 Zinc knuckle Salp15 PF12115.8 PIK36320.1 - 1.5 9.3 6.0 4.3 7.8 3.7 2.4 2 1 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Mito_fiss_reg PF05308.11 PIK36320.1 - 8.7 6.4 10.7 0.53 10.3 5.3 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator I-set PF07679.16 PIK36321.1 - 9.6e-08 32.0 0.0 5e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36321.1 - 2.4e-06 27.8 0.1 5.9e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK36321.1 - 2.5e-06 28.0 1.7 2.6e-06 27.9 0.3 1.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK36321.1 - 0.0012 19.0 1.0 0.0027 17.8 1.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain BatD PF13584.6 PIK36321.1 - 0.0036 16.2 0.3 0.0052 15.6 0.3 1.2 1 0 0 1 1 1 1 Oxygen tolerance MtrG PF04210.13 PIK36322.1 - 0.0072 16.2 4.9 0.66 9.9 0.3 3.8 2 2 2 4 4 4 1 Tetrahydromethanopterin S-methyltransferase, subunit G Baculo_PEP_C PF04513.12 PIK36322.1 - 0.01 15.9 0.1 0.025 14.6 0.1 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Alpha-2-MRAP_C PF06401.11 PIK36322.1 - 0.011 15.7 0.8 0.014 15.4 0.8 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF922 PF06037.11 PIK36322.1 - 0.019 14.7 0.2 0.036 13.8 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Med9 PF07544.13 PIK36322.1 - 0.035 14.2 4.7 0.29 11.2 0.5 2.9 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Occludin_ELL PF07303.13 PIK36322.1 - 0.042 14.6 0.7 0.071 13.8 0.7 1.5 1 0 0 1 1 1 0 Occludin homology domain NPV_P10 PF05531.12 PIK36322.1 - 0.043 14.3 0.7 2.9 8.4 0.3 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 PIK36322.1 - 0.05 13.9 2.8 0.19 12.0 1.1 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 PIK36322.1 - 0.053 13.6 2.3 0.27 11.3 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 PIK36322.1 - 0.054 13.9 8.1 0.11 13.0 3.9 2.9 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 PIK36322.1 - 0.063 13.5 6.7 0.052 13.8 2.3 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF16 PF01519.16 PIK36322.1 - 0.063 13.8 4.0 0.13 12.7 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Spc7 PF08317.11 PIK36322.1 - 0.096 11.6 4.5 0.13 11.1 4.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 PIK36322.1 - 0.12 13.1 3.0 0.24 12.0 3.0 1.7 1 1 0 1 1 1 0 Initiation control protein YabA Fez1 PF06818.15 PIK36322.1 - 0.13 12.7 4.2 0.22 12.0 1.3 2.1 2 0 0 2 2 2 0 Fez1 DUF2730 PF10805.8 PIK36322.1 - 0.4 10.8 2.7 1.6 8.9 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Pkinase_Tyr PF07714.17 PIK36323.1 - 1.1e-46 159.3 0.0 1.5e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36323.1 - 2.8e-17 63.0 0.0 4.7e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain PLATZ PF04640.14 PIK36323.1 - 0.027 15.1 0.0 0.089 13.4 0.0 1.9 1 0 0 1 1 1 0 PLATZ transcription factor I-set PF07679.16 PIK36323.1 - 0.066 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF2064 PF09837.9 PIK36323.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) Ig_3 PF13927.6 PIK36324.1 - 7.9e-09 36.0 1.1 1.4e-06 28.7 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK36324.1 - 1.9e-08 34.4 0.8 6.7e-07 29.4 0.1 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK36324.1 - 2.3e-07 31.0 2.8 9.8e-05 22.6 0.1 3.5 2 2 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK36324.1 - 0.00048 20.1 0.1 0.0025 17.9 0.1 2.2 2 1 0 2 2 2 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK36324.1 - 0.035 14.2 0.1 1.2 9.2 0.1 2.7 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK36325.1 - 3.3e-09 37.2 2.0 3.9e-05 24.2 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK36325.1 - 6.2e-09 36.0 0.2 6.5e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK36325.1 - 2e-08 34.5 1.0 0.0014 19.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Kinesin PF00225.23 PIK36325.1 - 3.9e-08 32.6 0.5 8.4e-08 31.5 0.5 1.5 1 1 0 1 1 1 1 Kinesin motor domain I-set PF07679.16 PIK36325.1 - 5.2e-07 29.6 0.2 0.00011 22.2 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK36325.1 - 8.4e-07 29.1 4.0 0.0038 17.4 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain ABC_membrane PF00664.23 PIK36325.1 - 0.00095 18.9 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region Microtub_bd PF16796.5 PIK36325.1 - 0.002 18.1 0.1 0.0075 16.2 0.1 2.0 2 0 0 2 2 2 1 Microtubule binding DUF4446 PF14584.6 PIK36325.1 - 0.0069 16.4 1.4 0.018 15.0 1.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) MAT1 PF06391.13 PIK36325.1 - 0.012 15.5 4.0 0.025 14.4 4.0 1.5 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Ig_4 PF16680.5 PIK36325.1 - 0.017 15.4 0.7 2.5 8.4 0.0 3.5 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain SIT PF15330.6 PIK36325.1 - 0.017 15.5 0.1 0.049 14.1 0.1 1.8 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF1664 PF07889.12 PIK36325.1 - 0.053 13.6 3.0 0.42 10.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) C2-set_2 PF08205.12 PIK36325.1 - 0.073 13.2 0.2 0.21 11.7 0.2 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF996 PF06195.13 PIK36325.1 - 0.088 13.1 0.4 0.26 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) APG6_N PF17675.1 PIK36325.1 - 1.7 9.2 10.3 4.2 7.9 10.3 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region DivIC PF04977.15 PIK36325.1 - 2.6 7.9 5.6 5 7.0 4.1 2.1 1 1 1 2 2 2 0 Septum formation initiator Ig_3 PF13927.6 PIK36326.1 - 6.4e-11 42.7 3.0 2.4e-07 31.2 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK36326.1 - 2.2e-08 34.1 0.2 3.2e-07 30.3 0.0 2.5 2 1 1 3 3 3 1 Immunoglobulin I-set domain ig PF00047.25 PIK36326.1 - 7.8e-07 29.2 4.2 2.8e-05 24.2 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK36326.1 - 6e-05 23.2 2.4 0.00026 21.1 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK36326.1 - 0.00012 22.3 4.6 0.00057 20.2 0.1 2.7 2 1 1 3 3 3 1 Immunoglobulin domain Marek_A PF02124.15 PIK36326.1 - 0.00018 21.5 0.1 0.00034 20.5 0.1 1.4 1 0 0 1 1 1 1 Marek's disease glycoprotein A C1-set PF07654.15 PIK36326.1 - 0.00027 21.3 1.5 0.019 15.3 0.2 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK36326.1 - 0.00052 20.0 1.8 0.0046 17.0 0.6 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK36326.1 - 0.0024 17.9 0.1 0.008 16.2 0.0 2.0 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 PIK36326.1 - 0.035 14.3 0.3 0.54 10.5 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin C2-set domain Fascin PF06268.13 PIK36326.1 - 0.047 13.9 0.1 12 6.2 0.0 2.4 2 0 0 2 2 2 0 Fascin domain Ig_6 PF18452.1 PIK36326.1 - 0.059 12.9 0.0 0.19 11.3 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK36327.1 - 1.2e-13 51.4 7.4 1.4e-05 25.6 0.4 3.9 3 1 1 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK36327.1 - 1.7e-07 31.2 2.1 0.0035 17.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36327.1 - 6.9e-06 26.3 12.8 0.0034 17.7 0.8 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK36327.1 - 0.00034 20.7 8.7 0.046 13.9 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK36327.1 - 0.00038 20.8 0.2 0.00038 20.8 0.2 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain V-set PF07686.17 PIK36327.1 - 0.0036 17.5 0.2 0.0036 17.5 0.2 3.0 3 1 0 3 3 3 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK36327.1 - 0.0041 17.1 0.0 0.074 13.1 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 PIK36327.1 - 0.0079 16.2 2.4 0.011 15.7 0.4 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK36328.1 - 1e-05 26.0 0.2 0.00019 21.9 0.0 2.6 2 1 1 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK36328.1 - 5e-05 23.3 0.1 0.00031 20.8 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK36328.1 - 0.01 15.9 0.4 0.035 14.2 0.3 1.9 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK36328.1 - 0.015 14.8 0.0 0.043 13.4 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain C1-set PF07654.15 PIK36328.1 - 0.03 14.7 1.6 1.2 9.6 0.5 2.8 2 1 0 2 2 2 0 Immunoglobulin C1-set domain Ig_2 PF13895.6 PIK36328.1 - 0.039 14.3 2.3 0.27 11.6 0.1 2.4 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK36328.1 - 0.045 13.9 3.4 0.51 10.5 0.1 3.4 2 2 1 3 3 3 0 Immunoglobulin domain Izumo-Ig PF16706.5 PIK36328.1 - 0.045 13.8 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK36328.1 - 0.066 13.6 0.5 1.1 9.7 0.0 2.8 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF1493 PF07377.12 PIK36328.1 - 0.14 12.7 0.0 3.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) V-set PF07686.17 PIK36328.1 - 2.1 8.5 4.6 0.89 9.8 0.2 2.6 2 2 1 3 3 3 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK36329.1 - 2.2e-05 24.9 0.3 0.002 18.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK36329.1 - 2.9e-05 24.3 1.0 0.012 16.0 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.5 PIK36329.1 - 0.16 12.4 0.5 3.1 8.3 0.5 2.4 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Docking PF08990.11 PIK36329.1 - 0.21 11.2 0.2 0.35 10.5 0.2 1.3 1 0 0 1 1 1 0 Erythronolide synthase docking DUF1258 PF06869.12 PIK36331.1 - 0.0032 17.0 0.0 0.0073 15.8 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1258) Transposase_21 PF02992.14 PIK36331.1 - 0.0047 16.2 0.0 0.008 15.4 0.0 1.4 1 0 0 1 1 1 1 Transposase family tnp2 Vault PF01505.18 PIK36332.1 - 0.12 12.6 0.7 6.4 7.0 0.0 2.9 2 2 0 2 2 2 0 Major Vault Protein repeat domain SRCR PF00530.18 PIK36333.1 - 3.5e-19 69.2 0.3 3.9e-19 69.0 0.3 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain PEP-utilizers PF00391.23 PIK36333.1 - 0.0076 15.9 0.0 0.013 15.2 0.0 1.5 1 1 0 1 1 1 1 PEP-utilising enzyme, mobile domain SRCR PF00530.18 PIK36334.1 - 2.6e-47 159.4 3.6 6.4e-29 100.4 0.5 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK36334.1 - 5.4e-10 39.7 0.8 1.5e-06 28.6 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK36334.1 - 2.3e-06 28.1 0.5 0.0029 18.1 0.0 2.7 2 2 0 2 2 2 2 Hepsin, SRCR domain SapB_2 PF03489.17 PIK36334.1 - 0.054 13.6 0.0 53 4.1 0.0 3.8 4 0 0 4 4 4 0 Saposin-like type B, region 2 SRCR PF00530.18 PIK36335.1 - 1.1e-126 414.2 28.8 1.1e-27 96.5 1.7 6.2 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK36335.1 - 3e-24 85.4 13.3 9.1e-06 26.1 0.2 5.4 4 1 1 5 5 5 4 Scavenger receptor cysteine-rich domain Fz PF01392.22 PIK36335.1 - 1.6e-23 83.4 3.0 1.6e-15 57.7 0.9 3.6 3 0 0 3 3 3 2 Fz domain Hepsin-SRCR PF09272.10 PIK36335.1 - 7.1e-12 45.8 0.1 0.19 12.3 0.0 4.8 4 1 0 4 4 4 4 Hepsin, SRCR domain WD40_alt PF14077.6 PIK36335.1 - 0.019 14.8 0.6 8 6.4 0.1 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF3551 PF12071.8 PIK36335.1 - 3.6 7.7 13.1 2.8 8.0 0.4 4.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3551) SRCR PF00530.18 PIK36336.1 - 2.5e-27 95.3 1.2 3e-27 95.0 1.2 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK36336.1 - 1.3e-06 28.9 0.1 1.7e-06 28.5 0.1 1.2 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK36336.1 - 3.3e-05 24.4 0.4 8.5e-05 23.0 0.4 1.7 1 1 0 1 1 1 1 Hepsin, SRCR domain Period_C PF12114.8 PIK36336.1 - 0.17 11.5 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region CLCA PF08434.11 PIK36337.1 - 1e-58 198.8 0.1 1.4e-58 198.3 0.1 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA_2 PF13519.6 PIK36337.1 - 3.3e-13 50.2 0.0 7.7e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK36337.1 - 1.2e-12 48.4 0.1 1.8e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK36337.1 - 2.8e-05 23.6 0.0 4.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK36337.1 - 0.0019 18.2 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1194 PF06707.11 PIK36337.1 - 0.076 12.2 0.4 0.96 8.6 0.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1194) Fibrinogen_C PF00147.18 PIK36338.1 - 1.4e-57 195.0 7.4 2e-57 194.6 7.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK36338.1 - 1.3e-06 28.3 11.9 1.3e-06 28.3 11.9 2.9 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK36338.1 - 0.00082 19.5 15.0 0.00082 19.5 15.0 4.1 3 2 1 4 4 4 1 EGF domain TIL PF01826.17 PIK36338.1 - 0.0014 18.8 12.5 0.0014 18.8 12.5 3.2 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain SEA PF01390.20 PIK36339.1 - 5.4e-11 42.5 0.1 9.3e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 SEA domain EGF_3 PF12947.7 PIK36339.1 - 0.02 15.1 6.7 0.035 14.3 6.7 1.3 1 0 0 1 1 1 0 EGF domain EGF PF00008.27 PIK36339.1 - 0.028 14.7 5.2 0.048 14.0 5.2 1.4 1 0 0 1 1 1 0 EGF-like domain TMIE PF16038.5 PIK36339.1 - 0.081 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 TMIE protein cEGF PF12662.7 PIK36339.1 - 0.096 12.6 0.2 0.096 12.6 0.2 2.9 3 0 0 3 3 3 0 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK36339.1 - 0.1 12.9 5.2 0.19 12.0 5.2 1.4 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK36339.1 - 0.14 12.4 5.0 0.28 11.4 5.0 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain OAD_gamma PF04277.13 PIK36339.1 - 0.2 12.2 2.5 0.36 11.4 2.5 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Plasmod_Pvs28 PF06247.11 PIK36339.1 - 3.8 7.9 7.8 2.4 8.6 3.8 2.6 2 0 0 2 2 2 0 Pvs28 EGF domain DUF5035 PF16438.5 PIK36340.1 - 0.00094 19.1 2.9 0.16 11.8 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5035) ADAM_spacer1 PF05986.14 PIK36340.1 - 0.083 12.9 0.3 2.1 8.4 0.1 2.1 2 0 0 2 2 2 0 ADAM-TS Spacer 1 Sushi PF00084.20 PIK36341.1 - 2.2e-19 69.8 35.1 7.4e-06 26.5 1.4 7.4 6 1 1 7 7 7 5 Sushi repeat (SCR repeat) DUF4050 PF13259.6 PIK36345.1 - 0.088 13.1 1.0 0.12 12.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) RVT_1 PF00078.27 PIK36347.1 - 2.6e-34 118.7 0.0 3.2e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK36349.1 - 4.2e-05 23.4 15.2 0.0032 17.5 3.3 3.3 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK36349.1 - 8.2e-05 22.3 14.3 0.28 11.0 0.4 3.7 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36349.1 - 0.0029 17.4 0.2 0.0029 17.4 0.2 2.9 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK36349.1 - 1.8 8.9 12.0 0.39 11.0 5.9 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain 7tm_1 PF00001.21 PIK36350.1 - 2.2e-24 86.2 4.9 2.9e-24 85.8 4.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK36350.1 - 7.2e-07 28.8 7.1 1.1e-06 28.3 7.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK36350.1 - 5.7e-06 26.2 14.1 7.5e-06 25.8 14.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK36350.1 - 0.00075 19.3 4.1 0.00098 18.9 4.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK36350.1 - 0.0025 17.4 12.0 0.0032 17.0 12.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Claudin_2 PF13903.6 PIK36350.1 - 0.65 9.7 6.5 0.29 10.9 3.1 1.8 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction SH3_1 PF00018.28 PIK36351.1 - 2.3e-13 49.5 0.0 3.4e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK36351.1 - 2.1e-08 33.9 0.0 3.2e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK36351.1 - 2.1e-07 30.5 0.0 3e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 PIK36351.1 - 5.1e-05 23.3 0.0 7.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 PIK36351.1 - 0.00047 20.4 0.0 0.00073 19.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.6 PIK36351.1 - 0.023 15.1 0.0 0.032 14.6 0.0 1.2 1 0 0 1 1 1 0 Helically-extended SH3 domain SH3_4 PF06347.13 PIK36351.1 - 0.09 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain Fungal_TACC PF12709.7 PIK36352.1 - 0.07 13.6 1.4 0.21 12.0 0.3 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins PTB PF08416.13 PIK36353.1 - 5.2e-28 97.8 0.2 8.4e-28 97.1 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain RVT_1 PF00078.27 PIK36355.1 - 0.0094 15.5 0.0 0.033 13.7 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YBD PF17725.1 PIK36355.1 - 0.061 13.2 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 YAP binding domain KDZ PF18758.1 PIK36356.1 - 1.1e-08 35.0 0.5 5.4e-08 32.7 0.1 2.2 1 1 1 2 2 2 1 Kyakuja-Dileera-Zisupton transposase Med29 PF11568.8 PIK36356.1 - 0.014 15.6 0.9 0.11 12.7 0.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 29 DUF1722 PF08349.11 PIK36356.1 - 0.52 10.6 3.4 0.5 10.7 0.6 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) DUF465 PF04325.13 PIK36356.1 - 7.8 6.6 7.6 6.2 6.9 0.8 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Transp_Tc5_C PF04236.15 PIK36357.1 - 0.0031 17.8 1.7 0.0062 16.9 1.7 1.4 1 0 0 1 1 1 1 Tc5 transposase C-terminal domain V-set PF07686.17 PIK36360.1 - 0.0098 16.1 0.1 0.022 14.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK36360.1 - 0.18 12.4 2.9 0.33 11.6 0.1 2.9 3 0 0 3 3 3 0 Immunoglobulin domain DUF3021 PF11457.8 PIK36360.1 - 0.49 10.7 3.3 0.24 11.8 1.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) WD40 PF00400.32 PIK36361.1 - 6.5e-51 169.2 27.5 2e-10 41.1 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK36361.1 - 4.9e-29 100.5 4.1 3.6e-07 30.4 0.3 6.1 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK36361.1 - 8.5e-12 45.4 0.7 6e-05 23.0 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 PIK36361.1 - 3.1e-09 36.4 0.0 6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 PIK36361.1 - 2.3e-05 23.9 0.0 0.13 11.5 0.0 3.4 4 1 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 PIK36361.1 - 0.00012 21.1 0.1 0.2 10.6 0.0 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 PIK36361.1 - 0.006 14.6 2.2 0.66 7.9 0.6 2.5 2 1 0 2 2 2 2 IKI3 family PD40 PF07676.12 PIK36361.1 - 0.0067 16.3 0.0 0.57 10.2 0.0 2.9 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 PIK36361.1 - 0.12 12.1 0.0 8.3 6.2 0.0 2.6 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Surp PF01805.20 PIK36362.1 - 1.7e-16 59.9 0.3 4.1e-16 58.7 0.3 1.7 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 PIK36362.1 - 1.1e-13 50.8 0.0 2.5e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 PIK36362.1 - 8e-06 26.6 0.3 3.2e-05 24.7 0.3 2.2 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.8 PIK36362.1 - 0.00031 20.7 0.1 0.00069 19.6 0.1 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 SET_assoc PF11767.8 PIK36362.1 - 0.0074 15.9 0.1 0.017 14.7 0.1 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 PIK36362.1 - 0.022 14.9 0.0 0.06 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif Lactamase_B_2 PF12706.7 PIK36363.1 - 4.6e-33 114.4 0.0 6.9e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK36363.1 - 1.4e-19 70.5 0.0 2.4e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 PIK36363.1 - 0.00022 21.3 0.6 0.0053 16.8 0.7 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily LRAT PF04970.13 PIK36364.1 - 1.1e-09 38.7 0.1 3.8e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK36364.1 - 0.01 15.6 0.1 0.26 11.1 0.0 2.4 2 0 0 2 2 2 0 PPPDE putative peptidase domain Lung_7-TM_R PF06814.13 PIK36365.1 - 2.9e-40 138.4 1.2 3.8e-40 138.0 1.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GPI2 PF06432.11 PIK36366.1 - 1.4e-40 139.5 17.4 1.7e-40 139.3 17.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Glyco_hydro_47 PF01532.20 PIK36367.1 - 6.7e-83 279.1 0.0 1.8e-82 277.7 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 NACHT PF05729.12 PIK36368.1 - 4.8e-09 36.3 0.0 1.1e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NLRC4_HD PF17889.1 PIK36368.1 - 0.0091 16.3 2.9 0.35 11.2 0.0 3.1 3 0 0 3 3 3 1 NLRC4 helical domain ER PF01133.17 PIK36368.1 - 0.034 14.1 0.5 0.074 13.1 0.5 1.5 1 0 0 1 1 1 0 Enhancer of rudimentary AAA_25 PF13481.6 PIK36368.1 - 0.046 13.3 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NAD_binding_5 PF07994.12 PIK36368.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase RT_RNaseH_2 PF17919.1 PIK36369.1 - 4.5e-38 129.3 0.0 6.7e-38 128.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36369.1 - 1.1e-35 122.1 0.0 1.7e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36370.1 - 3.3e-23 82.4 0.0 6.1e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK36370.1 - 1.4e-09 38.1 0.1 3.6e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK36370.1 - 1.9e-07 31.6 0.0 4.3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK36370.1 - 1.7e-06 27.8 17.9 0.0029 17.6 3.8 2.4 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 PIK36370.1 - 0.00016 22.3 0.0 0.00039 21.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_5 PF14787.6 PIK36370.1 - 0.066 12.9 14.8 0.096 12.4 4.3 2.4 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Peptidase_A2E PF12382.8 PIK36370.1 - 0.075 13.1 0.0 0.44 10.6 0.0 2.1 2 0 0 2 2 2 0 Retrotransposon peptidase Asp_protease PF09668.10 PIK36370.1 - 0.079 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 PIK36370.1 - 0.44 10.3 7.7 4.5 7.1 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle DEAD PF00270.29 PIK36371.1 - 1e-19 71.0 0.0 2.1e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK36371.1 - 8.4e-18 64.7 0.1 4.4e-17 62.4 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 PIK36371.1 - 5e-09 36.8 4.3 5e-09 36.8 4.3 2.0 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 PIK36371.1 - 3.7e-08 33.6 0.0 7.5e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HEM4 PF02602.15 PIK36371.1 - 0.025 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD SecA_DEAD PF07517.14 PIK36371.1 - 0.048 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain 53-BP1_Tudor PF09038.10 PIK36372.1 - 0.0096 15.9 0.1 0.94 9.4 0.0 2.6 2 1 0 2 2 2 2 Tumour suppressor p53-binding protein-1 Tudor Methyltransf_25 PF13649.6 PIK36373.1 - 1.6e-12 48.0 0.0 2.9e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36373.1 - 2e-12 47.6 0.0 3.3e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK36373.1 - 1.5e-09 37.8 0.0 2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK36373.1 - 2.3e-09 37.3 0.0 3.3e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36373.1 - 1.9e-07 31.7 0.0 3.1e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK36373.1 - 2.1e-06 27.4 0.0 2.6e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 PIK36373.1 - 8e-06 25.5 0.0 9.8e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 PIK36373.1 - 1e-05 25.1 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_29 PF03141.16 PIK36373.1 - 0.00027 19.6 0.0 0.00034 19.3 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 PIK36373.1 - 0.0019 17.8 0.1 0.0025 17.5 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CheR PF01739.18 PIK36373.1 - 0.0038 16.7 0.0 0.36 10.3 0.0 2.4 1 1 0 2 2 2 1 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 PIK36373.1 - 0.026 13.8 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 PIK36373.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M22 PF00814.25 PIK36374.1 - 2.8e-89 299.4 0.0 3.4e-89 299.2 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 PIK36374.1 - 0.003 17.3 0.0 0.052 13.2 0.0 2.2 2 0 0 2 2 2 1 Carbamoyltransferase N-terminus TPPII PF12580.8 PIK36374.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Tripeptidyl peptidase II zf-C2H2 PF00096.26 PIK36376.1 - 0.00056 20.2 10.9 1.8 9.2 0.1 4.9 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 PIK36376.1 - 0.027 14.6 5.4 0.25 11.5 0.1 3.3 1 1 1 3 3 3 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 PIK36376.1 - 0.073 13.9 11.0 4.6 8.4 0.6 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK36376.1 - 0.56 10.7 3.8 0.56 10.7 0.6 2.8 2 0 0 2 2 2 0 Zinc-finger double domain Proteasome PF00227.26 PIK36377.1 - 5.6e-50 169.5 0.1 6.7e-50 169.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit HECT PF00632.25 PIK36378.1 - 9.7e-99 330.7 0.2 1.3e-98 330.3 0.2 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 PIK36378.1 - 2.3e-46 155.5 23.2 1.2e-12 47.7 1.6 4.8 4 0 0 4 4 4 4 WW domain C2 PF00168.30 PIK36378.1 - 8.4e-10 38.9 0.0 1.8e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain MbtH PF03621.13 PIK36378.1 - 0.068 12.6 0.2 16 5.0 0.2 3.3 3 0 0 3 3 3 0 MbtH-like protein RRM_1 PF00076.22 PIK36379.1 - 1.3e-43 146.7 0.0 3.8e-23 81.1 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 PIK36379.1 - 9.4e-18 65.1 7.3 2.1e-17 64.0 3.8 2.8 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 PIK36379.1 - 1.2e-05 25.0 0.0 0.017 14.9 0.0 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF1866 PF08952.11 PIK36379.1 - 0.0012 18.7 0.0 0.57 10.0 0.0 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF1866) RRM_5 PF13893.6 PIK36379.1 - 0.0017 17.9 0.0 0.051 13.2 0.0 2.4 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36379.1 - 0.034 14.3 0.0 1.5 9.0 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif Polyoma_coat2 PF00761.20 PIK36379.1 - 0.055 13.2 0.2 0.088 12.5 0.2 1.2 1 0 0 1 1 1 0 Polyomavirus coat protein PHM7_cyt PF14703.6 PIK36379.1 - 0.21 11.8 1.3 26 5.0 0.0 2.9 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF4078 PF13300.6 PIK36379.1 - 9.1 6.7 9.1 3.7 7.9 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4078) V-set PF07686.17 PIK36380.1 - 0.0025 18.0 0.2 0.0058 16.8 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain MBG PF17883.1 PIK36380.1 - 0.023 15.3 0.5 0.051 14.2 0.5 1.5 1 0 0 1 1 1 0 MBG domain Ig_C17orf99 PF17736.1 PIK36380.1 - 0.067 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 C17orf99 Ig domain C2-set_2 PF08205.12 PIK36380.1 - 0.17 12.0 0.6 15 5.8 0.1 2.3 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain THAP PF05485.12 PIK36381.1 - 5.3e-16 59.3 2.5 8.8e-16 58.6 2.5 1.4 1 0 0 1 1 1 1 THAP domain Exo_endo_phos PF03372.23 PIK36382.1 - 1.1e-08 34.9 0.2 1.6e-08 34.4 0.2 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK36382.1 - 0.014 15.2 0.0 0.041 13.7 0.0 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Dickkopf_N PF04706.12 PIK36384.1 - 0.045 14.3 19.0 0.11 13.1 19.0 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Metallothio_6 PF05522.11 PIK36384.1 - 0.12 12.9 17.3 0.25 11.9 17.3 1.5 1 0 0 1 1 1 0 Metallothionein DX PF01666.17 PIK36384.1 - 0.83 10.2 18.7 0.094 13.2 7.9 2.6 1 1 1 2 2 2 0 DX module LicD PF04991.13 PIK36384.1 - 1.4 9.1 10.6 0.15 12.2 4.4 2.0 2 0 0 2 2 2 0 LicD family GRP PF07172.11 PIK36384.1 - 1.8 9.3 0.0 1.8 9.3 0.0 3.3 3 1 0 3 3 3 0 Glycine rich protein family Draxin PF15550.6 PIK36384.1 - 3.6 7.4 45.4 0.058 13.3 19.8 2.2 1 1 1 2 2 2 0 Draxin UPAR_LY6_2 PF16975.5 PIK36385.1 - 0.00029 21.0 1.8 0.00029 21.0 1.8 1.8 2 0 0 2 2 2 1 Ly6/PLAUR domain-containing protein 6, Lypd6 Tweety PF04906.13 PIK36386.1 - 2.7e-49 167.9 13.4 3.6e-49 167.5 13.4 1.0 1 0 0 1 1 1 1 Tweety DUF4131 PF13567.6 PIK36386.1 - 7.6e-06 25.7 0.1 7.6e-06 25.7 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4131) Wzy_C PF04932.15 PIK36386.1 - 0.031 13.9 1.3 2.7 7.6 0.1 2.3 2 0 0 2 2 2 0 O-Antigen ligase RWD PF05773.22 PIK36387.1 - 6.7e-15 55.4 0.4 8.8e-15 55.0 0.4 1.2 1 0 0 1 1 1 1 RWD domain Asp_protease_2 PF13650.6 PIK36388.1 - 3.8e-05 24.3 0.0 6.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK36388.1 - 0.00012 22.5 0.0 0.00025 21.5 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK36388.1 - 0.018 15.3 0.3 0.038 14.3 0.0 1.6 2 0 0 2 2 2 0 Retroviral aspartyl protease Asp_protease PF09668.10 PIK36388.1 - 0.14 12.0 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Aspartyl protease DUF3737 PF12541.8 PIK36389.1 - 0.033 13.4 0.6 3.8 6.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3737) BACK PF07707.15 PIK36389.1 - 0.058 13.5 0.6 0.12 12.5 0.6 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch BTB PF00651.31 PIK36389.1 - 0.069 13.4 0.1 0.19 11.9 0.1 1.8 1 0 0 1 1 1 0 BTB/POZ domain DUF5110 PF17137.4 PIK36389.1 - 0.12 12.7 0.3 0.23 11.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) Bromodomain PF00439.25 PIK36390.1 - 6.7e-13 48.5 0.1 1.4e-12 47.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain WD40 PF00400.32 PIK36390.1 - 1.8e-11 44.4 10.0 0.00039 21.2 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK36390.1 - 0.00068 19.9 0.0 0.37 11.1 0.2 3.9 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Auxin_resp PF06507.13 PIK36390.1 - 0.01 16.0 0.1 0.052 13.8 0.0 2.1 2 0 0 2 2 2 0 Auxin response factor YqaH PF17448.2 PIK36390.1 - 0.14 12.4 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized YqaH-like Prenyltransf PF01255.19 PIK36391.1 - 2.6e-64 216.8 1.3 4.2e-38 131.1 0.1 2.3 1 1 1 2 2 2 2 Putative undecaprenyl diphosphate synthase Ten1_2 PF15490.6 PIK36391.1 - 0.039 13.7 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Telomere-capping, CST complex subunit SKA2 PF16740.5 PIK36391.1 - 0.065 13.0 3.5 0.099 12.4 1.5 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Exo_endo_phos PF03372.23 PIK36392.1 - 2.1e-18 66.7 0.0 2.7e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK36392.1 - 0.00032 20.5 0.0 0.0028 17.5 0.0 2.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Ribosomal_L19 PF01245.20 PIK36393.1 - 9.6e-16 57.7 0.0 2e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L19 UCH PF00443.29 PIK36394.1 - 1.5e-46 159.0 2.0 4.1e-40 137.9 0.5 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 PIK36394.1 - 0.0018 18.6 4.9 0.24 11.7 0.6 2.8 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein Ima1_N PF09779.9 PIK36394.1 - 0.65 10.9 0.0 0.65 10.9 0.0 4.4 4 1 0 4 4 4 0 Ima1 N-terminal domain EGF PF00008.27 PIK36395.1 - 6.7e-17 61.5 34.4 7e-08 32.6 7.6 3.4 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK36395.1 - 1.1e-06 29.0 25.1 0.0017 18.9 3.0 4.5 4 1 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK36395.1 - 2.3e-06 27.8 34.8 0.0087 16.4 6.8 3.5 3 1 0 3 3 3 3 EGF-like domain Laminin_EGF PF00053.24 PIK36395.1 - 6.1e-06 26.3 26.9 0.057 13.6 3.1 3.3 1 1 2 3 3 3 3 Laminin EGF domain DSL PF01414.19 PIK36395.1 - 0.0037 17.5 20.6 0.01 16.1 11.2 2.3 2 0 0 2 2 2 2 Delta serrate ligand EGF_3 PF12947.7 PIK36395.1 - 0.0088 16.2 29.1 0.36 11.1 3.7 3.5 3 1 0 3 3 3 3 EGF domain EGF_CA PF07645.15 PIK36395.1 - 0.026 14.7 4.7 0.026 14.7 4.7 3.5 2 1 1 3 3 3 0 Calcium-binding EGF domain EGF_alliinase PF04863.13 PIK36395.1 - 0.08 13.4 1.6 0.08 13.4 1.6 4.6 2 1 3 5 5 5 0 Alliinase EGF-like domain EGF PF00008.27 PIK36396.1 - 9.3e-101 329.6 248.6 1.8e-08 34.5 0.5 20.5 19 1 1 20 20 20 19 EGF-like domain hEGF PF12661.7 PIK36396.1 - 6.1e-45 150.4 206.6 0.00016 22.2 3.3 21.7 20 0 0 20 20 20 18 Human growth factor-like EGF CUB PF00431.20 PIK36396.1 - 5.7e-06 26.6 0.0 2e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 CUB domain EGF_2 PF07974.13 PIK36396.1 - 6.8e-05 23.1 288.1 0.0035 17.7 9.3 20.6 19 1 1 20 20 20 13 EGF-like domain EGF_3 PF12947.7 PIK36396.1 - 0.0018 18.5 4.5 0.0018 18.5 4.5 20.0 19 1 1 20 20 20 13 EGF domain EGF_CA PF07645.15 PIK36396.1 - 0.0036 17.5 7.2 0.0036 17.5 7.2 20.6 5 4 15 20 20 20 6 Calcium-binding EGF domain Comm PF15957.5 PIK36396.1 - 0.058 13.7 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Commissureless Fibrinogen_C PF00147.18 PIK36397.1 - 4e-62 209.9 4.3 4e-62 209.9 4.3 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK36397.1 - 1.4e-06 28.4 8.5 1.4e-06 28.4 8.5 3.9 3 1 0 3 3 3 1 EGF domain TILa PF12714.7 PIK36397.1 - 0.0021 18.0 5.8 0.0021 18.0 5.8 2.8 1 1 1 2 2 2 1 TILa domain cEGF PF12662.7 PIK36397.1 - 0.16 11.9 4.7 0.72 9.8 4.7 2.2 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK36397.1 - 6.4 6.9 17.9 0.045 13.8 7.0 2.8 2 1 1 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK36398.1 - 8.6e-43 146.7 1.1 1.2e-42 146.2 1.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK36398.1 - 7.5e-06 26.0 8.2 7.5e-06 26.0 8.2 2.8 3 0 0 3 3 3 1 EGF domain EGF PF00008.27 PIK36398.1 - 0.0008 19.7 3.0 0.0008 19.7 3.0 2.3 1 1 1 2 2 2 1 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK36398.1 - 0.0021 18.3 6.5 0.0067 16.7 6.5 2.0 1 1 0 1 1 1 1 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 PIK36398.1 - 0.01 15.8 4.1 0.021 14.9 4.1 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 cEGF PF12662.7 PIK36398.1 - 0.03 14.3 4.0 0.03 14.3 4.0 3.4 4 1 0 4 4 4 0 Complement Clr-like EGF-like hEGF PF12661.7 PIK36398.1 - 0.078 13.6 3.1 0.078 13.6 3.1 2.7 3 0 0 3 3 3 0 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK36398.1 - 4.5 7.6 12.9 0.34 11.2 6.2 2.7 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site SMC_N PF02463.19 PIK36399.1 - 3.6e-12 46.2 8.7 3.6e-12 46.2 8.7 2.5 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK36399.1 - 2.1e-07 31.0 22.0 2.1e-07 31.0 22.0 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 PIK36399.1 - 3e-07 31.2 50.8 3e-07 31.2 50.8 5.6 2 2 1 3 3 3 1 AAA domain Filo_VP35 PF02097.15 PIK36399.1 - 0.001 18.2 0.2 0.0029 16.7 0.2 1.7 1 0 0 1 1 1 1 Filoviridae VP35 AAA_21 PF13304.6 PIK36399.1 - 0.0021 17.9 2.2 0.0021 17.9 2.2 3.1 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Cas_Csa5 PF09702.10 PIK36399.1 - 0.0062 16.8 1.2 4 7.8 0.9 3.2 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Csa5) DUF4763 PF15960.5 PIK36399.1 - 0.008 15.5 7.1 0.008 15.5 7.1 5.6 2 2 2 4 4 4 1 Domain of unknown function (DUF4763) AAA_29 PF13555.6 PIK36399.1 - 0.0091 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ChaC PF04752.12 PIK36399.1 - 0.11 12.5 0.4 0.26 11.3 0.4 1.6 1 0 0 1 1 1 0 ChaC-like protein PI_PP_I PF18363.1 PIK36399.1 - 2.9 8.1 9.5 1.6 8.9 0.1 4.2 3 1 0 4 4 4 0 Phosphoinositide phosphatase insertion domain SF3b10 PF07189.11 PIK36400.1 - 1.1e-39 134.4 0.0 1.2e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) RRM_3 PF08777.11 PIK36400.1 - 0.064 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif RCC1 PF00415.18 PIK36401.1 - 1.4e-12 48.1 5.7 1.8e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK36401.1 - 0.31 10.9 8.4 0.54 10.1 0.4 3.3 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat Atg8 PF02991.16 PIK36402.1 - 1.4e-49 166.5 0.1 1.6e-49 166.4 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 PIK36402.1 - 5.7e-08 33.1 0.0 7.1e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 DUF1143 PF06608.11 PIK36403.1 - 0.038 14.0 0.7 0.24 11.5 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1143) 3HCDH_N PF02737.18 PIK36404.1 - 7.1e-60 202.0 0.0 1.2e-59 201.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 PIK36404.1 - 7.4e-34 117.2 0.0 1.4e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 PIK36404.1 - 1.4e-31 109.0 0.0 5.7e-23 81.4 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 PIK36404.1 - 3.4e-17 62.9 0.0 3.4e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase NAD_Gly3P_dh_N PF01210.23 PIK36404.1 - 0.00042 20.3 0.0 0.001 19.1 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 PIK36404.1 - 0.071 12.7 0.3 0.16 11.5 0.3 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 PIK36404.1 - 0.074 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 PIK36404.1 - 0.11 13.1 1.2 0.22 12.1 0.3 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_S49 PF01343.18 PIK36404.1 - 0.12 12.3 0.1 14 5.6 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 Sulfatase PF00884.23 PIK36405.1 - 1e-66 225.5 0.1 1.4e-66 225.0 0.1 1.1 1 0 0 1 1 1 1 Sulfatase DUF4994 PF16385.5 PIK36405.1 - 0.0023 17.8 0.0 0.0097 15.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 PIK36405.1 - 0.042 14.6 0.0 0.12 13.1 0.0 1.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase NLPC_P60 PF00877.19 PIK36407.1 - 0.0077 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 NlpC/P60 family PXA PF02194.15 PIK36408.1 - 9.6e-31 107.2 0.4 9.6e-31 107.2 0.4 3.1 3 1 0 3 3 3 1 PXA domain RGS PF00615.19 PIK36408.1 - 1.4e-22 80.2 0.3 1.4e-22 80.2 0.3 2.6 3 0 0 3 3 3 1 Regulator of G protein signaling domain Nexin_C PF08628.12 PIK36408.1 - 1.5e-14 54.5 3.1 3.9e-14 53.2 0.0 3.2 3 1 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 PIK36408.1 - 7.6e-09 35.5 1.5 5.9e-08 32.7 0.1 3.1 3 0 0 3 3 3 1 PX domain DUF4131 PF13567.6 PIK36408.1 - 0.082 12.5 0.2 0.14 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3450 PF11932.8 PIK36408.1 - 0.092 12.0 3.7 0.26 10.6 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Retrotrans_gag PF03732.17 PIK36408.1 - 0.12 12.7 0.2 3.7 7.9 0.1 2.9 2 0 0 2 2 2 0 Retrotransposon gag protein Nif11 PF07862.11 PIK36408.1 - 0.8 10.1 4.4 0.53 10.6 0.3 2.9 3 0 0 3 3 3 0 Nif11 domain HIP1_clath_bdg PF16515.5 PIK36408.1 - 0.88 10.2 10.8 0.67 10.6 5.9 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YscO PF07321.12 PIK36408.1 - 3.3 7.7 9.4 3.7 7.5 0.2 2.7 2 0 0 2 2 2 0 Type III secretion protein YscO RVT_1 PF00078.27 PIK36409.1 - 6.1e-35 120.7 0.1 9.2e-35 120.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PP_kinase PF02503.17 PIK36409.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase middle domain EF-hand_1 PF00036.32 PIK36410.1 - 2.2e-23 80.0 12.6 2.5e-09 36.0 1.1 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 PIK36410.1 - 1.6e-20 73.3 6.9 3.6e-13 49.8 3.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK36410.1 - 1e-19 70.1 9.4 2.4e-12 46.5 0.9 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 PIK36410.1 - 3.4e-14 51.5 7.8 0.00031 20.4 0.2 3.6 3 1 0 3 3 3 3 EF-hand domain EF-hand_9 PF14658.6 PIK36410.1 - 2.6e-10 40.5 0.1 6.4e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK36410.1 - 1.4e-07 30.6 14.4 0.0006 19.2 1.5 3.7 3 1 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 PIK36410.1 - 0.0028 17.6 5.6 0.041 13.8 1.7 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 PIK36410.1 - 0.0067 16.6 0.5 0.12 12.6 0.7 2.2 1 1 1 2 2 2 1 Dockerin type I domain SUB1_ProdP9 PF18213.1 PIK36410.1 - 0.028 14.3 1.1 0.044 13.6 0.4 1.7 1 1 0 1 1 1 0 SUB1 protease Prodomain ProdP9 FlgD PF03963.14 PIK36410.1 - 0.03 14.6 0.3 0.14 12.5 0.1 1.9 2 0 0 2 2 2 0 Flagellar hook capping protein - N-terminal region SPARC_Ca_bdg PF10591.9 PIK36410.1 - 0.041 14.2 1.4 0.087 13.1 1.1 1.6 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Sigma54_CBD PF04963.13 PIK36410.1 - 0.043 13.7 0.0 0.056 13.3 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain EF-hand_14 PF17959.1 PIK36410.1 - 0.067 13.5 0.8 0.19 12.1 0.3 2.0 1 1 0 2 2 2 0 EF-hand domain DUF21 PF01595.20 PIK36410.1 - 0.072 12.8 0.4 0.68 9.6 0.3 2.1 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain SurA_N_2 PF13623.6 PIK36410.1 - 0.077 12.9 2.1 2.8 7.8 0.2 2.6 1 1 2 3 3 3 0 SurA N-terminal domain EF-hand_11 PF08976.11 PIK36410.1 - 0.084 13.8 0.2 0.91 10.4 0.1 1.9 1 1 1 2 2 2 0 EF-hand domain DUF3349 PF11829.8 PIK36410.1 - 0.1 13.4 1.1 18 6.2 0.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) ERAP1_C PF11838.8 PIK36410.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 ERAP1-like C-terminal domain DUF3008 PF11450.8 PIK36410.1 - 0.26 11.5 0.1 0.26 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) LETM1 PF07766.13 PIK36410.1 - 0.28 10.5 2.9 0.26 10.6 1.0 1.7 1 1 0 1 1 1 0 LETM1-like protein Toxin_36 PF10550.9 PIK36410.1 - 0.38 12.2 5.7 19 6.9 0.4 3.6 3 0 0 3 3 3 0 Conantokin-G mollusc-toxin Fz PF01392.22 PIK36411.1 - 1.5e-26 93.2 4.1 2e-26 92.8 4.1 1.2 1 0 0 1 1 1 1 Fz domain NTR PF01759.21 PIK36412.1 - 4.2e-09 36.2 0.4 8.8e-09 35.1 0.4 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DUF4769 PF15992.5 PIK36412.1 - 0.016 15.0 0.5 0.046 13.5 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4769) F-box_4 PF15966.5 PIK36413.1 - 5.2e-33 113.4 0.2 8.4e-33 112.7 0.2 1.3 1 0 0 1 1 1 1 F-box F-box PF00646.33 PIK36413.1 - 0.015 15.2 0.2 0.025 14.4 0.2 1.3 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 PIK36413.1 - 0.069 13.1 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 F-box-like zf-TRAF_2 PF15965.5 PIK36414.1 - 3.1e-35 120.5 16.2 3.1e-35 120.5 16.2 2.3 3 0 0 3 3 3 1 TRAF-like zinc-finger PAE PF03283.13 PIK36415.1 - 8.2e-73 245.5 0.1 1.2e-72 245.1 0.1 1.2 1 0 0 1 1 1 1 Pectinacetylesterase CH PF00307.31 PIK36417.1 - 4.8e-17 62.1 0.3 9.2e-17 61.2 0.3 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain LZ3wCH PF18517.1 PIK36420.1 - 1.8e-26 92.0 3.4 1.8e-26 92.0 3.4 2.2 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Mnd1 PF03962.15 PIK36420.1 - 8.9e-15 54.7 0.1 3.8e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 Mnd1 HTH domain UPF0242 PF06785.11 PIK36420.1 - 0.01 16.0 5.2 0.012 15.7 5.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF1515 PF07439.11 PIK36420.1 - 0.17 12.0 2.3 0.26 11.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DivIC PF04977.15 PIK36420.1 - 1.3 8.8 6.0 97 2.8 5.8 2.8 1 1 0 2 2 2 0 Septum formation initiator Glyoxalase PF00903.25 PIK36421.1 - 1.6e-10 41.3 0.0 5.5e-10 39.5 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 PIK36421.1 - 0.0013 18.6 0.1 0.005 16.8 0.1 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain Arm PF00514.23 PIK36422.1 - 2.1e-06 27.5 4.8 0.023 14.7 0.2 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat IFRD PF05004.13 PIK36422.1 - 0.017 14.2 1.6 0.16 11.0 1.6 2.1 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Proteasom_PSMB PF10508.9 PIK36422.1 - 0.041 12.4 0.1 0.16 10.5 0.1 1.6 1 1 0 1 1 1 0 Proteasome non-ATPase 26S subunit FANCF PF11107.8 PIK36422.1 - 0.082 12.1 0.2 0.12 11.6 0.2 1.3 1 1 0 1 1 1 0 Fanconi anemia group F protein (FANCF) DUF1797 PF08796.10 PIK36423.1 - 0.12 12.5 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) Annexin PF00191.20 PIK36424.1 - 7.7e-98 320.6 14.1 2e-26 91.8 0.1 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 PIK36424.1 - 0.003 17.4 1.8 1.9 8.4 0.1 3.7 3 1 0 4 4 4 2 Myb DNA-binding like DUF2661 PF10860.8 PIK36424.1 - 0.06 13.5 0.6 4.3 7.5 0.1 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF2661) DUF4562 PF15123.6 PIK36425.1 - 1.1e-32 112.4 0.3 6.2e-31 106.7 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4562) DUF1104 PF06518.11 PIK36427.1 - 3.4 8.1 11.0 2 8.8 8.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1104) Ceramidase_alk PF04734.13 PIK36428.1 - 1.3e-209 697.1 0.1 1.5e-209 696.9 0.1 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 PIK36428.1 - 1.5e-32 112.8 0.0 2.5e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Ceramidase_alk PF04734.13 PIK36429.1 - 7.3e-202 671.5 0.0 8.9e-202 671.2 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 PIK36429.1 - 2.9e-26 92.3 0.0 4.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal HLH PF00010.26 PIK36430.1 - 1.1e-15 57.3 1.3 1.5e-15 56.9 0.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SH2 PF00017.24 PIK36431.1 - 2.3e-20 72.5 0.6 4.7e-20 71.5 0.1 1.8 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.28 PIK36431.1 - 2.4e-17 62.3 1.0 1.6e-11 43.6 0.3 2.8 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 PIK36431.1 - 3.6e-15 55.6 0.7 5.2e-07 29.4 0.1 3.0 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 PIK36431.1 - 2.4e-14 52.7 0.1 9.8e-07 28.4 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain hSH3 PF14603.6 PIK36431.1 - 0.00079 19.8 0.0 0.023 15.1 0.0 2.3 2 0 0 2 2 2 1 Helically-extended SH3 domain SH2_2 PF14633.6 PIK36431.1 - 0.13 11.6 0.0 0.36 10.2 0.0 1.7 1 1 1 2 2 2 0 SH2 domain RUN PF02759.19 PIK36432.1 - 2e-24 86.1 0.4 4.5e-24 84.9 0.1 1.8 2 0 0 2 2 2 1 RUN domain DUF4065 PF13274.6 PIK36432.1 - 0.0057 17.5 1.0 6.5 7.7 0.0 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4065) Eapp_C PF10238.9 PIK36433.1 - 0.015 15.4 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein RT_RNaseH_2 PF17919.1 PIK36434.1 - 2.2e-31 107.8 0.1 3.7e-31 107.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36434.1 - 1.1e-27 96.4 0.0 1.9e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CENP-R PF06729.12 PIK36434.1 - 0.016 15.2 0.1 0.026 14.5 0.1 1.3 1 0 0 1 1 1 0 Kinetochore component, CENP-R RAMP PF04901.13 PIK36436.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Receptor activity modifying family DUF1495 PF07381.11 PIK36436.1 - 0.053 13.3 0.1 0.086 12.7 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) Dynein_light PF01221.18 PIK36436.1 - 0.059 13.7 0.4 0.1 13.0 0.2 1.6 2 0 0 2 2 2 0 Dynein light chain type 1 Glu_cys_ligase PF04262.14 PIK36436.1 - 0.11 11.1 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase V-set PF07686.17 PIK36438.1 - 0.0036 17.5 0.0 0.012 15.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK36438.1 - 0.0091 16.2 1.0 0.17 12.1 0.1 3.0 3 0 0 3 3 3 1 Immunoglobulin domain Ig_6 PF18452.1 PIK36438.1 - 0.02 14.5 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 PIK36438.1 - 0.023 15.0 3.6 0.19 12.1 0.2 3.7 4 2 1 5 5 5 0 Immunoglobulin domain Ig_3 PF13927.6 PIK36438.1 - 0.036 14.7 1.0 1.3 9.6 0.1 3.3 3 2 1 4 4 4 0 Immunoglobulin domain Corona_NS3b PF03053.14 PIK36438.1 - 0.15 11.8 0.2 0.23 11.2 0.2 1.2 1 0 0 1 1 1 0 ORF3b coronavirus protein Pkinase_Tyr PF07714.17 PIK36439.1 - 8.9e-08 31.7 0.0 1.5e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36439.1 - 0.00049 19.6 0.1 0.0016 17.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain C2-set_2 PF08205.12 PIK36439.1 - 0.0049 16.9 0.1 0.0095 16.0 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain UTP15_C PF09384.10 PIK36439.1 - 0.083 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 UTP15 C terminal Exo_endo_phos_2 PF14529.6 PIK36440.1 - 0.00013 21.7 0.2 0.0014 18.4 0.2 2.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK36440.1 - 0.0018 17.8 0.0 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribonuc_2-5A PF06479.12 PIK36440.1 - 0.039 14.1 3.3 0.054 13.7 2.0 1.9 2 0 0 2 2 2 0 Ribonuclease 2-5A CheR_N PF03705.15 PIK36440.1 - 0.089 12.5 0.1 0.24 11.1 0.1 1.8 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain T4-Gluco-transf PF09198.10 PIK36440.1 - 0.12 12.0 0.2 0.38 10.4 0.2 1.8 1 0 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase EGF PF00008.27 PIK36441.1 - 4.2e-20 71.7 113.6 1.6e-06 28.3 6.4 11.5 11 0 0 11 11 11 8 EGF-like domain SLD5_C PF16922.5 PIK36441.1 - 8.3e-09 35.5 8.3 2.1 8.6 0.0 5.6 5 0 0 5 5 5 4 DNA replication complex GINS protein SLD5 C-terminus HYR PF02494.16 PIK36441.1 - 1.1e-08 35.3 22.2 0.0035 17.6 0.0 5.9 6 0 0 6 6 6 4 HYR domain EGF_2 PF07974.13 PIK36441.1 - 0.0049 17.2 6.1 0.0049 17.2 6.1 9.9 10 1 1 11 11 11 4 EGF-like domain Ig_2 PF13895.6 PIK36441.1 - 0.013 15.8 0.6 0.051 13.9 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Paramyxo_C PF01692.18 PIK36441.1 - 0.062 12.7 6.5 27 4.1 0.0 4.3 2 2 3 5 5 5 0 Paramyxovirus non-structural protein C Ig_3 PF13927.6 PIK36441.1 - 0.064 13.9 0.8 0.19 12.4 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain DUF4919 PF16266.5 PIK36441.1 - 2.9 7.8 5.0 63 3.4 0.2 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4919) Pribosyltran PF00156.27 PIK36442.1 - 1e-14 54.3 0.1 1.3e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF1180 PF06679.12 PIK36443.1 - 0.019 15.4 0.1 0.035 14.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Cadherin_C_2 PF16492.5 PIK36443.1 - 0.076 13.8 0.0 0.23 12.3 0.0 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 PIK36443.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Filamin PF00630.19 PIK36444.1 - 0.00057 20.7 0.0 0.0018 19.1 0.0 1.8 2 0 0 2 2 2 1 Filamin/ABP280 repeat Y_Y_Y PF07495.13 PIK36444.1 - 0.0031 17.4 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 Y_Y_Y domain COG6 PF06419.11 PIK36445.1 - 0.0044 15.3 0.1 0.0085 14.4 0.0 1.4 1 1 1 2 2 2 1 Conserved oligomeric complex COG6 tRNA_bind_2 PF13725.6 PIK36445.1 - 0.017 14.8 0.3 0.017 14.8 0.3 1.6 2 0 0 2 2 2 0 Possible tRNA binding domain RVP PF00077.20 PIK36446.1 - 0.004 17.4 0.0 0.015 15.6 0.0 2.0 2 1 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK36446.1 - 0.019 15.5 0.0 0.047 14.2 0.0 1.7 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4722 PF15849.5 PIK36446.1 - 0.034 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) Asp_protease_2 PF13650.6 PIK36446.1 - 0.083 13.5 0.0 0.18 12.5 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Vezatin PF12632.7 PIK36449.1 - 2.5e-12 46.8 0.1 5e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Mucin PF01456.17 PIK36449.1 - 0.04 13.9 4.4 0.088 12.8 4.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Podoplanin PF05808.11 PIK36449.1 - 7.1 6.7 7.8 19 5.3 7.8 1.7 1 0 0 1 1 1 0 Podoplanin FAM194 PF14977.6 PIK36450.1 - 7.2e-30 103.8 0.0 1.3e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 FAM194 protein Guanylate_kin PF00625.21 PIK36451.1 - 7.8e-32 110.4 0.0 8.9e-31 107.0 0.0 2.1 2 0 0 2 2 2 1 Guanylate kinase LRR_4 PF12799.7 PIK36451.1 - 4.9e-19 68.1 41.7 1.1e-06 28.9 2.9 5.1 1 1 7 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK36451.1 - 4.8e-16 58.7 6.1 5.2e-13 48.9 3.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK36451.1 - 1.4e-11 43.4 7.6 0.3 11.2 0.2 7.4 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 PIK36451.1 - 1.4e-11 43.9 24.5 4e-06 26.5 2.4 4.8 1 1 4 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 PIK36451.1 - 0.002 18.4 16.7 1.6 9.6 0.1 7.2 7 1 0 7 7 7 1 Leucine Rich Repeat TsaE PF02367.17 PIK36451.1 - 0.068 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE HEPN_LA2681 PF18733.1 PIK36451.1 - 0.15 11.3 1.0 0.25 10.6 0.1 1.8 2 0 0 2 2 2 0 LA2681-like HEPN Mab-21 PF03281.14 PIK36453.1 - 1.3e-100 336.5 0.0 1.6e-100 336.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein TUDOR PF00567.24 PIK36454.1 - 7e-22 77.7 0.1 7e-22 77.7 0.1 1.9 2 0 0 2 2 2 1 Tudor domain OST-HTH PF12872.7 PIK36454.1 - 2e-13 50.0 0.0 2.1e-07 30.7 0.1 2.8 3 0 0 3 3 3 2 OST-HTH/LOTUS domain Agenet PF05641.12 PIK36454.1 - 0.1 13.1 0.0 0.32 11.5 0.0 1.8 1 0 0 1 1 1 0 Agenet domain OST-HTH PF12872.7 PIK36455.1 - 1.4e-11 44.0 0.0 6.6e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 OST-HTH/LOTUS domain RabGAP-TBC PF00566.18 PIK36456.1 - 1.3e-36 126.3 2.7 4.9e-35 121.1 0.0 2.4 3 0 0 3 3 3 2 Rab-GTPase-TBC domain Dimerisation2 PF16864.5 PIK36456.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain Sulfotransfer_2 PF03567.14 PIK36457.1 - 6.9e-06 26.1 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK36457.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase domain Antistasin PF02822.14 PIK36458.1 - 1.8e-107 351.4 350.5 1.5e-09 38.3 11.8 20.2 21 1 0 21 21 21 16 Antistasin family WAP PF00095.21 PIK36458.1 - 1.7e-40 137.1 95.6 6.7e-11 42.4 11.6 13.4 8 1 0 8 8 8 5 WAP-type (Whey Acidic Protein) 'four-disulfide core' GIY-YIG PF01541.24 PIK36459.1 - 8e-06 26.1 0.0 0.0001 22.5 0.0 2.4 2 0 0 2 2 2 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK36459.1 - 0.00014 21.5 0.0 0.00033 20.3 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WAP PF00095.21 PIK36460.1 - 3.2e-61 203.5 151.1 4.7e-12 46.1 12.7 8.0 8 1 0 8 8 8 6 WAP-type (Whey Acidic Protein) 'four-disulfide core' Antistasin PF02822.14 PIK36460.1 - 8.1e-11 42.4 26.3 5.8e-07 30.0 7.3 9.6 8 3 0 8 8 8 2 Antistasin family BTB PF00651.31 PIK36461.1 - 1.1e-31 109.4 1.6 1.6e-31 108.8 1.6 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 PIK36461.1 - 9e-20 70.0 3.6 1.6e-10 40.4 0.4 3.6 2 1 1 3 3 3 3 Kelch motif BACK PF07707.15 PIK36461.1 - 3.8e-15 55.8 0.3 4.7e-12 45.9 0.1 2.7 3 0 0 3 3 3 2 BTB And C-terminal Kelch Kelch_6 PF13964.6 PIK36461.1 - 5.7e-12 45.5 1.5 7.9e-07 29.1 0.1 3.3 1 1 2 3 3 3 2 Kelch motif Kelch_2 PF07646.15 PIK36461.1 - 0.0014 18.6 1.9 0.07 13.1 0.1 3.3 2 1 1 3 3 3 1 Kelch motif Kelch_5 PF13854.6 PIK36461.1 - 0.0016 18.3 2.2 0.0047 16.9 0.5 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 PIK36461.1 - 0.0093 16.0 0.8 0.51 10.4 0.3 2.7 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK36461.1 - 0.022 15.0 5.9 0.26 11.6 0.5 3.1 3 1 0 3 3 3 0 Galactose oxidase, central domain PT PF04886.12 PIK36462.1 - 0.00089 18.8 2.8 1.4 8.5 0.0 3.8 3 1 0 3 3 3 2 PT repeat Sulfotransfer_3 PF13469.6 PIK36463.1 - 1.4e-06 28.9 0.0 1.8e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family 2-oxogl_dehyd_N PF16078.5 PIK36463.1 - 0.88 9.2 6.1 0.8 9.3 0.3 2.4 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus Sulfotransfer_3 PF13469.6 PIK36464.1 - 1.3e-05 25.7 0.1 2.3e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase family 2-oxogl_dehyd_N PF16078.5 PIK36464.1 - 0.85 9.3 6.1 1.6 8.4 0.3 2.5 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus Sulfotransfer_3 PF13469.6 PIK36465.1 - 1.6e-05 25.4 0.1 2.6e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase family 2-oxogl_dehyd_N PF16078.5 PIK36465.1 - 2.4 7.8 9.6 1.6 8.4 0.3 3.3 3 0 0 3 3 3 0 2-oxoglutarate dehydrogenase N-terminus RVT_1 PF00078.27 PIK36466.1 - 4.6e-20 72.1 0.1 8.3e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sulfotransfer_3 PF13469.6 PIK36467.1 - 5.1e-05 23.7 0.0 7e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 Sulfotransferase family 2-oxogl_dehyd_N PF16078.5 PIK36467.1 - 0.15 11.7 1.7 1 9.0 0.3 2.5 3 0 0 3 3 3 0 2-oxoglutarate dehydrogenase N-terminus Kinesin PF00225.23 PIK36468.1 - 2.4e-27 95.7 0.3 2.8e-27 95.5 0.3 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK36468.1 - 4.3e-20 72.2 0.1 5.6e-20 71.8 0.1 1.1 1 0 0 1 1 1 1 Microtubule binding DUF87 PF01935.17 PIK36468.1 - 0.23 11.5 0.2 0.4 10.7 0.2 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain MAPEG PF01124.18 PIK36469.1 - 4.4e-10 39.6 2.0 4.7e-10 39.5 2.0 1.0 1 0 0 1 1 1 1 MAPEG family zf-met PF12874.7 PIK36470.1 - 3.5e-06 27.2 19.2 0.0098 16.3 2.0 4.5 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK36470.1 - 8.2e-05 22.8 18.3 0.091 13.1 0.4 4.5 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK36470.1 - 0.0002 21.6 10.5 0.16 12.4 0.2 4.0 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 PIK36470.1 - 0.012 15.2 3.0 0.26 11.0 0.3 2.8 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF1840 PF08895.11 PIK36470.1 - 0.27 11.6 4.4 11 6.4 2.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Myc_N PF01056.18 PIK36470.1 - 1.3 8.9 5.2 0.53 10.1 3.0 1.5 2 0 0 2 2 2 0 Myc amino-terminal region Sugar_tr PF00083.24 PIK36471.1 - 9.4e-112 374.1 31.4 5.5e-86 289.2 19.7 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK36471.1 - 3.5e-28 98.5 37.9 1.9e-24 86.3 28.3 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 PIK36471.1 - 0.0011 17.5 3.0 0.0011 17.5 3.0 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PSI_integrin PF17205.3 PIK36471.1 - 0.011 15.5 4.2 0.019 14.7 4.2 1.4 1 0 0 1 1 1 0 Integrin plexin domain PSI PF01437.25 PIK36471.1 - 1.4 9.6 8.3 2.6 8.7 8.3 1.5 1 0 0 1 1 1 0 Plexin repeat ABC_membrane_2 PF06472.15 PIK36473.1 - 5e-34 117.9 0.5 7.5e-34 117.4 0.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 PIK36473.1 - 6.3e-17 62.4 0.0 2e-16 60.8 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 PIK36473.1 - 0.0017 18.9 0.3 0.006 17.1 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 PIK36473.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK36473.1 - 0.0081 15.9 0.1 0.02 14.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 PIK36473.1 - 0.013 15.0 0.0 0.24 10.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 PIK36473.1 - 0.033 14.1 0.2 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain ATPase_2 PF01637.18 PIK36473.1 - 0.12 12.2 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 PIK36473.1 - 0.13 12.6 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Pyr_redox_dim PF02852.22 PIK36474.1 - 1.2e-29 102.7 0.1 1.8e-29 102.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 PIK36474.1 - 1.1e-22 80.6 0.0 1.5e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK36474.1 - 5.7e-12 46.0 0.0 1.2e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK36474.1 - 1.3e-05 24.7 0.0 1.8e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SymE_toxin PF08845.10 PIK36474.1 - 0.067 13.3 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Toxin SymE, type I toxin-antitoxin system Cadherin-like PF12733.7 PIK36475.1 - 1.3e-18 67.3 1.8 1.1e-11 45.1 0.1 2.4 2 0 0 2 2 2 2 Cadherin-like beta sandwich domain TPR_11 PF13414.6 PIK36475.1 - 8.7e-11 41.3 0.0 0.00083 19.0 0.0 4.2 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.6 PIK36475.1 - 5.9e-05 23.2 2.2 1 9.9 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK36475.1 - 0.00011 22.8 0.0 0.1 13.3 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK36475.1 - 0.014 15.4 0.2 0.34 11.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Endotoxin_C PF03944.14 PIK36475.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 delta endotoxin TPR_19 PF14559.6 PIK36475.1 - 0.15 12.6 2.8 2.4 8.7 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK36475.1 - 2.9 8.7 5.3 86 4.1 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Porphobil_deam PF01379.20 PIK36477.1 - 0.07 12.6 0.1 0.086 12.3 0.1 1.1 1 0 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain NADase_NGA PF07461.11 PIK36477.1 - 0.08 11.8 0.0 0.094 11.6 0.0 1.1 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) Bcl-2 PF00452.19 PIK36478.1 - 6.7e-13 49.2 0.0 1.3e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family zf-H2C2_2 PF13465.6 PIK36479.1 - 9.7e-165 528.4 181.6 5.7e-10 39.2 3.5 20.1 20 0 0 20 20 20 20 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36479.1 - 2.3e-91 295.4 177.2 1.8e-06 28.1 3.6 19.1 19 0 0 19 19 19 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36479.1 - 1.8e-76 246.1 155.7 0.00015 22.3 5.7 19.1 19 0 0 19 19 19 19 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36479.1 - 1.6e-34 117.4 127.3 0.0045 17.2 0.6 19.1 18 1 1 19 19 19 13 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK36479.1 - 2.1e-29 101.2 114.9 0.19 11.6 0.4 19.1 18 1 1 19 19 19 17 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK36479.1 - 1.7e-21 75.6 78.2 0.0094 15.7 0.3 18.3 19 0 0 19 19 19 7 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 PIK36479.1 - 1.3e-20 72.8 90.4 0.38 10.7 0.5 19.4 19 0 0 19 19 19 10 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK36479.1 - 3.7e-13 49.7 122.4 0.02 15.3 1.1 18.8 1 1 18 19 19 19 6 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK36479.1 - 4e-09 36.3 129.0 0.15 12.1 3.1 19.1 1 1 18 19 19 19 3 BED zinc finger zf-H2C2_5 PF13909.6 PIK36479.1 - 1.4e-07 31.1 11.9 7.9e-05 22.3 0.7 24.1 20 9 0 20 20 19 6 C2H2-type zinc-finger domain zf-CHCC PF10276.9 PIK36479.1 - 4.6e-07 29.8 143.0 0.67 10.1 0.3 19.1 19 0 0 19 19 19 9 Zinc-finger domain zf-AN1 PF01428.16 PIK36479.1 - 1.1e-05 25.4 126.9 9.6 6.5 0.2 19.2 13 3 6 19 19 19 0 AN1-like Zinc finger zf-met PF12874.7 PIK36479.1 - 1.4e-05 25.3 132.7 0.086 13.3 1.9 17.4 18 0 0 18 18 16 6 Zinc-finger of C2H2 type Glyco_hydro_2_C PF02836.17 PIK36479.1 - 1.9e-05 23.9 42.9 0.22 10.6 1.1 6.3 1 1 4 6 6 6 5 Glycosyl hydrolases family 2, TIM barrel domain zf-Di19 PF05605.12 PIK36479.1 - 2.6e-05 24.4 108.6 0.077 13.3 3.7 13.5 1 1 12 16 16 16 6 Drought induced 19 protein (Di19), zinc-binding DUF3506 PF12014.8 PIK36479.1 - 3.8e-05 23.7 11.3 24 4.9 0.1 9.4 4 4 5 10 10 10 0 Domain of unknown function (DUF3506) zf-C2H2_6 PF13912.6 PIK36479.1 - 0.00023 21.1 172.6 0.23 11.5 1.6 21.3 19 2 0 19 19 19 9 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 PIK36479.1 - 0.00028 21.6 100.6 0.49 11.2 1.5 10.6 2 2 7 12 12 12 9 zinc-ribbon family DUF1294 PF06961.13 PIK36479.1 - 0.013 15.7 0.3 71 3.7 0.0 4.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) C1_4 PF07975.12 PIK36479.1 - 0.018 15.2 110.5 0.069 13.4 3.1 12.6 1 1 15 17 17 17 0 TFIIH C1-like domain Sulfakinin PF08257.11 PIK36479.1 - 0.21 11.7 4.5 23 5.5 0.1 4.0 4 0 0 4 4 3 0 Sulfakinin family GAGA PF09237.11 PIK36479.1 - 0.35 10.7 40.6 8.8 6.2 0.0 10.4 2 2 6 12 12 12 0 GAGA factor DUF3268 PF11672.8 PIK36479.1 - 1.4 9.2 96.7 0.11 12.9 3.0 10.2 1 1 8 13 13 13 0 zinc-finger-containing domain BolA PF01722.18 PIK36479.1 - 1.8 8.9 30.7 9.6 6.6 1.1 8.2 5 3 4 9 9 9 0 BolA-like protein zf-C2H2_2 PF12756.7 PIK36479.1 - 2.7 8.4 126.2 1.9 8.8 0.8 18.1 1 1 17 18 18 18 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 PIK36479.1 - 2.9 8.6 70.5 13 6.5 0.6 13.1 1 1 3 7 7 7 0 Zinc finger C2H2-type, 3 repeats Zf_RING PF16744.5 PIK36479.1 - 6.3 7.0 86.7 4.8 7.4 0.2 17.4 1 1 18 19 19 19 0 KIAA1045 RING finger zinc_ribbon_9 PF14369.6 PIK36479.1 - 6.6 7.1 54.8 45 4.4 0.1 16.3 19 0 0 19 19 19 0 zinc-ribbon Yippee-Mis18 PF03226.14 PIK36479.1 - 7.5 6.8 71.2 2.6 8.3 3.8 11.2 2 2 4 6 6 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-H2C2_2 PF13465.6 PIK36480.1 - 6.7e-79 257.1 107.0 8.8e-10 38.6 1.1 11.8 12 0 0 12 12 11 11 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36480.1 - 3.1e-44 147.0 93.9 2.6e-05 24.4 2.6 11.4 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36480.1 - 9.2e-40 131.9 92.5 0.00011 22.8 5.8 11.7 12 0 0 12 12 11 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36480.1 - 7.4e-16 58.0 71.5 0.016 15.5 0.6 11.3 11 0 0 11 11 11 8 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK36480.1 - 9.1e-14 51.1 55.4 0.36 10.8 0.4 10.7 11 0 0 11 11 11 10 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.6 PIK36480.1 - 6.8e-11 41.8 51.2 0.76 9.7 0.4 10.9 10 0 0 10 10 10 7 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 PIK36480.1 - 1.5e-08 34.4 85.4 0.036 14.1 6.2 11.1 10 0 0 10 10 10 7 C2H2-type zinc finger zf-AN1 PF01428.16 PIK36480.1 - 5.9e-07 29.5 61.5 2.9 8.1 0.3 10.6 7 1 3 10 10 10 3 AN1-like Zinc finger zf-C2H2_11 PF16622.5 PIK36480.1 - 8e-07 28.7 49.2 0.22 11.3 0.2 10.2 11 0 0 11 11 11 5 zinc-finger C2H2-type C1_4 PF07975.12 PIK36480.1 - 6.4e-06 26.3 48.2 0.03 14.6 2.5 7.0 2 1 5 8 8 8 5 TFIIH C1-like domain zf-ribbon_3 PF13248.6 PIK36480.1 - 8.5e-05 21.8 26.6 7.7 6.1 0.0 9.7 10 0 0 10 10 10 1 zinc-ribbon domain DUF3506 PF12014.8 PIK36480.1 - 0.00031 20.7 2.3 16 5.5 0.2 6.0 2 1 2 5 5 5 0 Domain of unknown function (DUF3506) zf-C2HE PF16278.5 PIK36480.1 - 0.00033 21.0 68.6 0.12 12.9 0.4 10.8 2 2 8 10 10 10 2 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK36480.1 - 0.012 15.7 68.7 2.4 8.3 1.5 10.3 1 1 8 9 9 9 0 BED zinc finger zf-Di19 PF05605.12 PIK36480.1 - 0.03 14.6 60.5 0.45 10.8 3.9 8.1 2 1 6 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 PIK36480.1 - 0.24 12.1 52.3 1.2 10.0 4.2 6.4 1 1 2 6 6 6 0 zinc-ribbon family YyzF PF14116.6 PIK36480.1 - 0.84 9.7 43.7 15 5.7 0.2 10.0 10 0 0 10 10 10 0 YyzF-like protein zf_UBZ PF18439.1 PIK36480.1 - 1.6 8.4 50.4 3.4 7.3 0.5 10.1 11 0 0 11 11 11 0 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 PIK36480.1 - 2.8 8.3 42.9 5.2 7.4 0.7 5.5 3 1 0 5 5 5 0 zinc-finger-containing domain GAGA PF09237.11 PIK36480.1 - 4.1 7.3 26.4 1.3 8.9 0.1 6.8 1 1 5 8 8 8 0 GAGA factor SIR2_2 PF13289.6 PIK36481.1 - 0.12 12.5 0.0 19 5.3 0.0 2.7 3 0 0 3 3 3 0 SIR2-like domain Exo_endo_phos_2 PF14529.6 PIK36482.1 - 2e-12 47.0 0.0 4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK36482.1 - 0.00077 19.1 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LMBR1 PF04791.16 PIK36482.1 - 4 6.2 6.6 5.6 5.8 6.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Amidase PF01425.21 PIK36483.1 - 7.6e-17 61.4 0.0 8.6e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Amidase SAD_SRA PF02182.17 PIK36484.1 - 2.9e-25 88.8 0.0 4.1e-24 85.0 0.0 2.1 2 0 0 2 2 2 1 SAD/SRA domain Methyltransf_23 PF13489.6 PIK36485.1 - 0.00018 21.4 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36485.1 - 0.0026 18.3 0.0 0.0047 17.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK36485.1 - 0.0071 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36485.1 - 0.047 14.4 0.0 0.11 13.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain SAD_SRA PF02182.17 PIK36486.1 - 7.5e-27 94.0 0.0 2.4e-26 92.3 0.0 1.7 1 1 0 1 1 1 1 SAD/SRA domain Methyltransf_23 PF13489.6 PIK36487.1 - 0.00043 20.2 0.0 0.0007 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36487.1 - 0.0059 17.2 0.0 0.013 16.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK36487.1 - 0.0093 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36487.1 - 0.13 13.0 0.0 0.31 11.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain HPD PF05044.12 PIK36487.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Homeo-prospero domain Sushi PF00084.20 PIK36488.1 - 5.5e-62 206.2 89.9 1.4e-08 35.2 1.7 9.6 10 0 0 10 10 10 9 Sushi repeat (SCR repeat) Trypsin PF00089.26 PIK36488.1 - 1.2e-61 208.3 0.1 2.5e-61 207.3 0.1 1.6 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK36488.1 - 6.4e-05 23.3 0.0 0.00016 22.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) HRM PF02793.22 PIK36488.1 - 0.0022 18.2 74.7 0.98 9.8 3.0 10.4 6 3 4 10 10 10 6 Hormone receptor domain Sushi PF00084.20 PIK36489.1 - 3.1e-81 267.9 110.5 3.7e-09 37.0 3.1 12.1 12 0 0 12 12 12 11 Sushi repeat (SCR repeat) HRM PF02793.22 PIK36489.1 - 5.9e-07 29.7 75.2 0.0079 16.5 0.5 11.0 9 2 2 11 11 11 7 Hormone receptor domain SEA PF01390.20 PIK36490.1 - 9.7e-11 41.7 0.0 2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 SEA domain Zn_peptidase PF04228.13 PIK36490.1 - 0.0075 15.7 0.0 0.01 15.3 0.0 1.1 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase Herpes_US9 PF06072.11 PIK36490.1 - 0.017 15.0 0.2 0.031 14.1 0.2 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Ac76 PF05814.11 PIK36490.1 - 0.047 13.7 0.2 0.11 12.6 0.1 1.6 2 0 0 2 2 2 0 Orf76 (Ac76) TMEM107 PF14995.6 PIK36490.1 - 0.053 14.0 0.4 0.14 12.6 0.2 1.7 1 1 1 2 2 2 0 Transmembrane protein DUF4293 PF14126.6 PIK36490.1 - 0.067 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) SNARE PF05739.19 PIK36490.1 - 0.11 12.5 1.2 0.18 11.8 1.2 1.4 1 0 0 1 1 1 0 SNARE domain DUF2663 PF10864.8 PIK36490.1 - 0.14 12.6 0.1 0.34 11.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2663) Prominin PF05478.11 PIK36490.1 - 0.24 9.3 0.0 0.31 9.0 0.0 1.1 1 0 0 1 1 1 0 Prominin zf-C4 PF00105.18 PIK36492.1 - 1.5e-27 95.9 11.5 2.5e-27 95.1 11.5 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) zf-C2H2_assoc2 PF16624.5 PIK36492.1 - 8.8 7.4 10.6 0.14 13.2 0.9 2.5 2 1 0 2 2 2 0 Unstructured region upstream of a zinc-finger Prok-RING_1 PF14446.6 PIK36492.1 - 9.2 6.3 9.4 1.1 9.3 3.2 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Hormone_recep PF00104.30 PIK36493.1 - 2.4e-11 43.6 0.1 2.8e-11 43.4 0.1 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Rad51 PF08423.11 PIK36493.1 - 0.13 11.5 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Rad51 Collagen PF01391.18 PIK36494.1 - 1.3e-07 31.2 20.9 2.7e-07 30.2 20.9 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) UPF0552 PF10574.9 PIK36495.1 - 2.6e-21 76.0 0.0 2.9e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Arp2/3-interacting proteins Arpin ATP-synt_D PF01813.17 PIK36496.1 - 4.6e-75 251.8 6.0 5.5e-75 251.5 6.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D DUF2090 PF09863.9 PIK36496.1 - 0.042 12.9 0.6 0.077 12.0 0.3 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) RICH PF05062.12 PIK36496.1 - 0.21 12.0 6.7 0.22 11.9 0.2 3.0 3 1 0 3 3 3 0 RICH domain HSP90 PF00183.18 PIK36497.1 - 2.1e-209 696.7 39.1 7.6e-209 694.9 39.1 1.7 1 1 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 PIK36497.1 - 9.5e-14 51.9 0.0 2e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 PIK36497.1 - 1.8e-11 44.0 0.1 5.7e-11 42.4 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2052 PF09747.9 PIK36497.1 - 0.092 12.9 19.0 0.038 14.1 14.8 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF3408 PF11888.8 PIK36497.1 - 4.1 7.5 20.9 1.1 9.4 15.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) CDC45 PF02724.14 PIK36497.1 - 8.6 4.5 17.5 14 3.8 17.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Fer2_2 PF01799.20 PIK36498.1 - 6.6e-26 90.1 0.0 8.5e-26 89.8 0.0 1.1 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C2 PF02738.18 PIK36499.1 - 4e-61 207.1 0.0 4.9e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Thioredoxin PF00085.20 PIK36501.1 - 3.1e-05 23.9 0.0 0.001 19.0 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 PIK36501.1 - 0.0036 17.2 0.0 0.043 13.7 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin-like domain TBP PF00352.21 PIK36501.1 - 0.0071 16.3 0.0 0.12 12.4 0.0 2.6 2 1 1 3 3 3 1 Transcription factor TFIID (or TATA-binding protein, TBP) Mitoc_L55 PF09776.9 PIK36502.1 - 4.3e-35 119.9 0.5 5.6e-35 119.6 0.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Pox_C7_F8A PF03287.14 PIK36502.1 - 0.059 13.4 0.1 0.071 13.1 0.1 1.2 1 0 0 1 1 1 0 Poxvirus C7/F8A protein GILT PF03227.16 PIK36503.1 - 7.7e-33 112.9 1.3 1.7e-32 111.8 1.3 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SapA PF02199.15 PIK36503.1 - 0.0012 19.1 4.2 0.0012 19.1 4.2 2.2 2 0 0 2 2 2 1 Saposin A-type domain Thioredoxin_4 PF13462.6 PIK36503.1 - 0.042 14.0 0.1 0.27 11.4 0.1 2.1 1 1 0 1 1 1 0 Thioredoxin Y_phosphatase PF00102.27 PIK36504.1 - 2.2e-140 466.0 7.9 1.1e-79 267.4 0.2 3.2 2 1 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK36504.1 - 3.8e-33 113.7 7.0 1.1e-14 54.5 0.1 5.8 5 0 0 5 5 5 4 Fibronectin type III domain DSPc PF00782.20 PIK36504.1 - 4.1e-07 29.9 0.0 0.0067 16.3 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK36504.1 - 1.6e-06 28.3 0.0 0.016 15.1 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK36504.1 - 2.6e-05 24.4 0.0 0.037 14.2 0.0 2.8 2 0 0 2 2 2 2 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.5 PIK36504.1 - 0.0029 18.1 5.1 0.034 14.7 0.0 3.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK36504.1 - 0.0038 17.5 0.0 5.5 7.4 0.0 4.2 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III fn3_4 PF16794.5 PIK36504.1 - 0.051 13.5 0.3 0.31 11.0 0.0 2.5 3 0 0 3 3 3 0 Fibronectin-III type domain fn3 PF00041.21 PIK36505.1 - 6.1e-39 132.2 9.3 2e-14 53.7 0.1 3.2 3 0 0 3 3 3 3 Fibronectin type III domain Interfer-bind PF09294.10 PIK36505.1 - 4e-08 33.5 0.1 0.0049 17.2 0.1 3.3 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 PIK36505.1 - 3e-06 27.7 9.3 0.022 15.3 0.4 3.9 3 2 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK36505.1 - 0.015 15.7 0.0 1.8 9.0 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Raftlin PF15250.6 PIK36507.1 - 0.085 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Raftlin RT_RNaseH PF17917.1 PIK36508.1 - 3.8e-05 23.9 0.2 0.00015 22.0 0.2 2.0 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK36508.1 - 0.00062 19.6 0.2 0.001 18.8 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK36508.1 - 0.078 13.0 0.0 0.34 11.0 0.0 2.0 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Phage_integrase PF00589.22 PIK36509.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family SPX PF03105.19 PIK36510.1 - 0.0073 16.3 5.7 0.0072 16.3 5.7 1.0 1 0 0 1 1 1 1 SPX domain Pex14_N PF04695.13 PIK36510.1 - 0.014 16.1 7.2 0.018 15.7 7.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sigma70_ner PF04546.13 PIK36510.1 - 0.018 14.9 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4834 PF16118.5 PIK36510.1 - 0.034 15.1 0.2 0.056 14.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Apt1 PF10351.9 PIK36510.1 - 0.046 12.6 8.5 0.05 12.5 8.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nop14 PF04147.12 PIK36510.1 - 0.1 10.8 7.9 0.12 10.5 7.9 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 PIK36510.1 - 0.11 10.8 7.9 0.12 10.7 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein RP-C_C PF11800.8 PIK36510.1 - 0.13 12.4 2.4 0.15 12.1 2.4 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region SpoIIIAH PF12685.7 PIK36510.1 - 0.15 11.9 7.8 0.18 11.6 7.8 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CCDC106 PF15794.5 PIK36510.1 - 0.27 10.9 8.6 0.31 10.7 8.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DNA_pol_phi PF04931.13 PIK36510.1 - 0.62 8.1 8.5 0.75 7.8 8.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi PI3K_1B_p101 PF10486.9 PIK36510.1 - 0.66 7.7 8.5 0.73 7.5 8.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4614 PF15391.6 PIK36510.1 - 1.1 9.2 16.0 1.4 8.9 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) AF-4 PF05110.13 PIK36510.1 - 1.1 7.2 17.2 1.3 7.1 17.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Presenilin PF01080.17 PIK36510.1 - 4.5 5.9 8.5 5.5 5.7 8.5 1.0 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 PIK36510.1 - 5.5 5.4 10.2 6.4 5.2 10.2 1.0 1 0 0 1 1 1 0 Macoilin family BUD22 PF09073.10 PIK36510.1 - 7.5 5.8 15.6 9.4 5.5 15.6 1.1 1 0 0 1 1 1 0 BUD22 RVT_1 PF00078.27 PIK36511.1 - 6.3e-05 22.6 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DED PF01335.21 PIK36512.1 - 3.7e-13 49.6 1.2 9.3e-07 29.1 0.2 2.2 2 0 0 2 2 2 2 Death effector domain DED PF01335.21 PIK36513.1 - 1.6e-08 34.7 0.1 1.9e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 Death effector domain PPTA PF01239.22 PIK36514.1 - 2.3e-53 176.5 12.9 8.2e-12 44.4 0.9 5.7 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 PIK36514.1 - 0.04 14.3 1.8 4.6 7.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4219 PF13961.6 PIK36514.1 - 0.9 9.3 12.4 5.3 6.8 1.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) O-FucT PF10250.9 PIK36516.1 - 0.11 12.1 1.2 0.14 11.9 0.1 1.6 2 0 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase UBD PF16455.5 PIK36517.1 - 0.14 12.4 0.5 11 6.3 0.3 2.7 2 0 0 2 2 2 0 Ubiquitin-binding domain Cellulose_synt PF03552.14 PIK36517.1 - 0.34 9.3 5.5 0.85 8.0 5.5 1.7 1 0 0 1 1 1 0 Cellulose synthase A_deaminase PF00962.22 PIK36518.1 - 5e-91 305.4 0.1 1.3e-90 304.1 0.1 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase zf-H2C2_2 PF13465.6 PIK36521.1 - 8.9e-157 503.3 169.3 3.2e-10 39.9 1.2 18.1 18 0 0 18 18 18 18 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36521.1 - 6.1e-72 234.3 173.5 9.9e-06 25.7 0.8 17.9 18 0 0 18 18 18 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36521.1 - 5.3e-62 201.1 155.7 0.00057 20.5 3.5 17.8 18 0 0 18 18 18 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36521.1 - 3.2e-27 94.2 124.8 0.026 14.8 0.6 17.6 16 2 2 18 18 18 14 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK36521.1 - 7.2e-19 67.4 105.9 0.31 11.0 1.8 17.1 14 2 3 17 17 17 12 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_1 PF00130.22 PIK36521.1 - 7e-12 45.0 72.8 0.063 13.2 1.1 13.3 1 1 13 15 15 15 8 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.5 PIK36521.1 - 3.3e-09 36.3 82.2 0.033 13.9 1.7 15.5 17 0 0 17 17 17 6 zinc-finger C2H2-type zf-C2HE PF16278.5 PIK36521.1 - 7.8e-08 32.7 121.4 0.091 13.2 0.8 16.9 1 1 15 16 16 16 7 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 PIK36521.1 - 1.6e-06 27.9 96.6 2.7 8.0 0.3 17.3 17 0 0 17 17 17 6 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 PIK36521.1 - 0.00012 21.8 7.5 0.0025 17.5 2.0 21.4 20 7 0 20 20 19 9 C2H2-type zinc-finger domain GAGA PF09237.11 PIK36521.1 - 0.00037 20.2 44.6 0.14 12.0 0.5 10.8 2 2 6 12 12 12 2 GAGA factor zf-CHCC PF10276.9 PIK36521.1 - 0.00062 19.8 115.7 1.2 9.2 0.2 16.4 17 0 0 17 17 17 9 Zinc-finger domain zf-C2H2_6 PF13912.6 PIK36521.1 - 0.0017 18.3 149.6 0.11 12.6 1.0 18.0 17 1 0 17 17 17 7 C2H2-type zinc finger zf-AN1 PF01428.16 PIK36521.1 - 0.0017 18.5 117.9 4.5 7.5 0.3 17.2 12 4 5 17 17 17 3 AN1-like Zinc finger DUF1294 PF06961.13 PIK36521.1 - 0.016 15.4 1.6 18 5.6 0.0 6.0 8 0 0 8 8 7 0 Protein of unknown function (DUF1294) zinc_ribbon_15 PF17032.5 PIK36521.1 - 0.29 11.9 88.0 0.75 10.6 3.5 9.2 1 1 14 15 15 15 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 PIK36521.1 - 0.33 11.6 60.9 2.6 8.8 0.5 10.7 1 1 5 8 8 8 0 Zinc finger C2H2-type, 3 repeats C1_4 PF07975.12 PIK36521.1 - 0.38 11.0 98.5 0.46 10.8 2.0 10.6 2 2 12 15 15 15 0 TFIIH C1-like domain BolA PF01722.18 PIK36521.1 - 0.45 10.8 39.0 18 5.7 0.4 8.6 7 2 0 7 7 7 0 BolA-like protein YyzF PF14116.6 PIK36521.1 - 8.9 6.4 90.6 19 5.4 0.2 16.7 13 3 4 17 17 17 0 YyzF-like protein zf-H2C2_2 PF13465.6 PIK36522.1 - 1.1e-37 126.8 55.5 4.1e-10 39.6 3.7 6.6 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK36522.1 - 2e-16 59.4 49.0 0.00013 22.3 4.4 5.9 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36522.1 - 3.9e-16 58.4 40.1 0.00018 22.1 2.3 5.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36522.1 - 2.4e-10 40.4 30.6 0.01 16.1 0.5 5.3 4 1 1 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK36522.1 - 7.9e-09 35.1 21.9 0.0087 15.8 0.5 5.8 6 0 0 6 6 6 3 zinc-finger C2H2-type PyrI_C PF02748.15 PIK36522.1 - 4.9e-07 29.5 28.0 0.15 12.0 0.8 5.3 5 0 0 5 5 5 4 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.6 PIK36522.1 - 3.1e-06 26.9 23.2 0.13 12.2 0.1 5.4 5 0 0 5 5 5 3 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 PIK36522.1 - 0.0011 18.9 41.2 0.31 11.1 2.4 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-CHCC PF10276.9 PIK36522.1 - 0.0085 16.1 32.8 3.6 7.7 1.2 5.5 5 0 0 5 5 5 4 Zinc-finger domain Glyco_hydro_2_C PF02836.17 PIK36522.1 - 0.026 13.6 4.4 0.26 10.3 4.2 2.2 1 1 1 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain zf-AN1 PF01428.16 PIK36522.1 - 0.065 13.4 28.6 9.3 6.5 0.4 5.5 3 1 2 5 5 5 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 PIK36522.1 - 0.096 13.4 14.0 0.16 12.7 0.7 4.1 2 1 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 PIK36522.1 - 0.097 13.0 3.1 6.6 7.1 0.2 2.7 1 1 0 2 2 2 0 BolA-like protein GAGA PF09237.11 PIK36522.1 - 0.12 12.1 6.1 1.8 8.4 0.1 3.4 1 1 2 4 4 4 0 GAGA factor C1_4 PF07975.12 PIK36522.1 - 0.14 12.4 23.5 0.51 10.6 3.4 3.8 2 1 0 3 3 3 0 TFIIH C1-like domain zf-Paramyx-P PF13008.7 PIK36522.1 - 0.21 11.1 11.8 2.2 7.8 0.4 4.2 4 0 0 4 4 4 0 Zinc-binding domain of Paramyxoviridae V protein zf-Di19 PF05605.12 PIK36522.1 - 0.81 10.0 26.1 3.2 8.1 6.1 3.8 1 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 PIK36522.1 - 2.2 7.9 22.2 5.2 6.8 0.4 5.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Zf_RING PF16744.5 PIK36522.1 - 2.5 8.3 19.9 41 4.4 4.3 5.0 1 1 4 5 5 5 0 KIAA1045 RING finger zf-C2HE PF16278.5 PIK36522.1 - 3 8.4 33.0 3.7 8.1 3.4 5.3 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.5 PIK36522.1 - 3.4 8.5 24.6 2.7 8.8 3.7 3.5 2 1 0 4 4 3 0 zinc-ribbon family FYVE PF01363.21 PIK36522.1 - 4.3 7.5 21.5 5.7 7.2 9.5 3.5 1 1 1 2 2 2 0 FYVE zinc finger zf-BED PF02892.15 PIK36522.1 - 4.4 7.4 32.5 0.77 9.8 2.6 5.4 1 1 4 5 5 5 0 BED zinc finger YyzF PF14116.6 PIK36522.1 - 8.1 6.6 29.5 14 5.8 0.8 5.3 3 2 2 5 5 5 0 YyzF-like protein Ammonium_transp PF00909.21 PIK36524.1 - 2.3e-28 99.0 6.3 2.7e-28 98.8 6.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family BACK PF07707.15 PIK36525.1 - 5.2e-22 77.9 0.8 1.1e-21 76.8 0.2 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 PIK36525.1 - 3.4e-21 75.5 0.3 1.4e-20 73.6 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 PIK36526.1 - 5.1e-36 122.0 0.8 6.9e-09 35.2 0.0 5.5 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 PIK36526.1 - 1.3e-26 92.0 0.0 4.3e-05 23.6 0.0 5.3 4 1 1 5 5 5 5 Kelch motif Kelch_4 PF13418.6 PIK36526.1 - 1.9e-19 69.4 0.0 2.4e-05 24.3 0.0 4.8 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK36526.1 - 2.3e-19 69.2 0.0 1.6e-05 25.1 0.0 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK36526.1 - 1.5e-18 66.0 0.1 0.018 15.0 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 PIK36526.1 - 1.1e-14 54.1 0.1 6.7e-05 22.8 0.0 4.5 4 0 0 4 4 4 3 Kelch motif RAG2 PF03089.14 PIK36526.1 - 0.086 11.8 0.0 0.24 10.3 0.0 1.8 2 0 0 2 2 2 0 Recombination activating protein 2 WAP PF00095.21 PIK36527.1 - 1.3e-07 31.8 19.5 2.9e-07 30.8 19.5 1.6 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Vault PF01505.18 PIK36527.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Major Vault Protein repeat domain Pex2_Pex12 PF04757.14 PIK36528.1 - 8.6e-27 94.2 5.1 1.3e-26 93.6 5.1 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 PIK36528.1 - 0.00013 21.8 7.4 0.00022 21.0 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK36528.1 - 0.0029 17.7 8.9 0.0052 16.9 8.9 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 PIK36528.1 - 0.03 14.4 8.7 0.057 13.5 8.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK36528.1 - 0.041 13.7 7.0 0.083 12.7 7.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK36528.1 - 0.1 12.5 5.4 0.16 11.8 5.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK36528.1 - 0.13 12.7 7.6 0.22 11.9 7.6 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_6 PF14835.6 PIK36528.1 - 0.16 11.9 2.2 0.34 10.8 2.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 PIK36528.1 - 0.72 9.8 6.5 1.1 9.1 6.5 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PNMA PF14893.6 PIK36529.1 - 3.2e-08 33.4 0.7 6.9e-08 32.3 0.4 1.6 1 1 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK36529.1 - 0.0035 17.6 2.6 0.014 15.6 1.1 2.5 1 1 2 3 3 3 1 Retrotransposon gag protein gag-asp_proteas PF13975.6 PIK36529.1 - 0.033 14.7 0.0 0.091 13.3 0.0 1.8 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease Blo-t-5 PF11642.8 PIK36529.1 - 0.042 13.8 1.0 0.088 12.8 1.0 1.5 1 0 0 1 1 1 0 Mite allergen Blo t 5 Asp_protease_2 PF13650.6 PIK36529.1 - 0.067 13.8 0.0 0.17 12.6 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease P53 PF00870.18 PIK36529.1 - 0.44 10.3 2.0 4.3 7.1 0.2 2.2 2 0 0 2 2 2 0 P53 DNA-binding domain RT_RNaseH_2 PF17919.1 PIK36530.1 - 1.1e-29 102.4 0.0 2e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36530.1 - 1e-25 90.0 0.0 1.8e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36530.1 - 6.2e-18 65.1 0.0 1.1e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK36530.1 - 1.2e-15 57.3 0.8 2.3e-15 56.4 0.8 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain PSI_PsaJ PF01701.18 PIK36530.1 - 0.15 12.6 0.1 0.35 11.4 0.1 1.7 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ DUF4288 PF14119.6 PIK36531.1 - 0.015 15.7 0.1 0.12 12.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) Rootletin PF15035.6 PIK36532.1 - 3.4e-11 43.5 0.4 3.4e-11 43.5 0.4 10.1 3 2 4 7 7 7 2 Ciliary rootlet component, centrosome cohesion HIP1_clath_bdg PF16515.5 PIK36532.1 - 0.016 15.8 5.3 0.016 15.8 5.3 13.4 4 2 11 15 15 15 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 PIK36532.1 - 0.028 13.3 199.3 0.015 14.2 7.2 9.4 3 1 6 9 9 9 0 Spc7 kinetochore protein ATG16 PF08614.11 PIK36533.1 - 1.6e-06 28.5 4.6 1.9e-06 28.2 4.6 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 PIK36533.1 - 3.5e-05 23.8 12.4 0.0069 16.4 5.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.20 PIK36533.1 - 0.0054 16.1 11.0 0.0081 15.6 11.0 1.2 1 0 0 1 1 1 1 Tropomyosin MscS_porin PF12795.7 PIK36533.1 - 0.0069 16.0 9.0 0.009 15.6 9.0 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Tropomyosin_1 PF12718.7 PIK36533.1 - 0.035 14.2 7.9 0.051 13.7 7.9 1.2 1 0 0 1 1 1 0 Tropomyosin like DUF4472 PF14739.6 PIK36533.1 - 0.042 14.6 7.1 0.15 12.8 7.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) EzrA PF06160.12 PIK36533.1 - 0.043 12.0 3.3 0.052 11.7 3.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DHR10 PF18595.1 PIK36533.1 - 0.047 13.8 14.4 0.059 13.4 6.1 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain PEARLI-4 PF05278.12 PIK36533.1 - 0.078 12.6 9.0 0.2 11.2 3.2 2.0 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4200 PF13863.6 PIK36533.1 - 0.09 13.2 10.3 0.13 12.7 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 PIK36533.1 - 0.1 12.0 5.7 0.16 11.3 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ERM PF00769.19 PIK36533.1 - 0.13 12.1 14.7 0.18 11.6 14.7 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family FemAB PF02388.16 PIK36533.1 - 0.15 10.9 1.1 0.2 10.5 1.1 1.1 1 0 0 1 1 1 0 FemAB family ADIP PF11559.8 PIK36533.1 - 0.15 12.1 8.8 0.17 11.9 8.0 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 PIK36533.1 - 0.2 11.7 3.8 0.16 12.0 2.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4164 PF13747.6 PIK36533.1 - 0.5 10.7 9.6 0.087 13.1 5.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) GAS PF13851.6 PIK36533.1 - 0.89 8.9 10.6 0.36 10.2 3.7 1.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 PIK36533.1 - 0.89 9.6 11.3 3.9 7.5 11.5 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4349 PF14257.6 PIK36533.1 - 2 7.8 7.9 2.6 7.4 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) APG6_N PF17675.1 PIK36533.1 - 2.3 8.7 12.9 0.26 11.8 6.0 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 PIK36533.1 - 3.2 6.6 12.0 1.2 7.9 5.3 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein TEX13 PF15186.6 PIK36533.1 - 4.3 7.0 10.7 0.91 9.2 3.3 2.1 1 1 0 2 2 2 0 Testis-expressed sequence 13 protein family Fmp27_WPPW PF10359.9 PIK36533.1 - 7.3 5.3 7.9 16 4.2 8.0 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FPP PF05911.11 PIK36534.1 - 8.1e-05 21.0 32.5 8.1e-05 21.0 32.5 2.1 2 0 0 2 2 2 1 Filament-like plant protein, long coiled-coil DUF5082 PF16888.5 PIK36534.1 - 0.00097 19.4 13.6 0.00097 19.4 13.6 4.2 2 1 2 4 4 4 3 Domain of unknown function (DUF5082) DUF4200 PF13863.6 PIK36534.1 - 0.0073 16.7 13.0 0.0073 16.7 13.0 4.6 2 1 3 5 5 5 1 Domain of unknown function (DUF4200) DUF3450 PF11932.8 PIK36534.1 - 0.0092 15.3 12.4 0.0092 15.3 12.4 5.0 2 1 3 5 5 5 1 Protein of unknown function (DUF3450) Spc7 PF08317.11 PIK36534.1 - 0.013 14.4 60.1 0.083 11.8 20.5 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein APG6_N PF17675.1 PIK36534.1 - 0.2 12.2 72.2 0.34 11.5 9.8 4.5 2 1 1 4 4 4 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 PIK36534.1 - 0.51 10.4 66.6 0.089 12.8 8.6 6.5 2 1 5 7 7 7 0 TATA element modulatory factor 1 DNA binding KASH_CCD PF14662.6 PIK36534.1 - 0.99 9.2 61.6 1.1 9.0 8.7 3.8 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 PIK36534.1 - 1.9 8.2 64.5 17 5.1 16.9 3.3 1 1 3 4 4 4 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 PIK36534.1 - 3.6 7.6 41.3 0.077 13.0 7.0 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Tektin PF03148.14 PIK36534.1 - 4.3 6.0 50.5 2 7.1 30.5 3.5 2 1 0 3 3 3 0 Tektin family ZapB PF06005.12 PIK36534.1 - 6 7.4 62.9 0.1 13.0 1.9 6.1 3 2 2 5 5 5 0 Cell division protein ZapB DUF724 PF05266.14 PIK36534.1 - 6.2 6.6 48.1 0.2 11.5 12.0 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF724) TSC22 PF01166.18 PIK36534.1 - 8.3 6.8 25.4 2.2 8.7 0.2 6.6 4 2 3 7 7 7 0 TSC-22/dip/bun family CENP-F_leu_zip PF10473.9 PIK36534.1 - 9.2 6.3 61.6 0.16 12.0 8.7 4.4 2 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 PIK36534.1 - 9.8 6.5 50.7 2.7 8.3 3.0 5.3 2 1 3 5 5 5 0 Seryl-tRNA synthetase N-terminal domain SCO1-SenC PF02630.14 PIK36535.1 - 3.9e-48 162.8 0.0 5.6e-48 162.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 PIK36535.1 - 2.4e-07 30.7 0.0 3.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 PIK36535.1 - 0.00025 21.3 0.0 0.0006 20.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 PIK36535.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.5 1 1 0 1 1 1 0 Redoxin Pkinase_Tyr PF07714.17 PIK36537.1 - 2.5e-94 315.4 0.0 3.5e-94 314.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36537.1 - 1.5e-45 155.6 0.0 2.2e-44 151.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 PIK36537.1 - 5.7e-24 84.0 0.1 1.1e-23 83.1 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK36537.1 - 7.7e-10 38.2 0.0 1.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK36537.1 - 2.6e-08 33.4 0.0 5.6e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK36537.1 - 8.6e-08 31.9 0.0 1.6e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK36537.1 - 0.00012 22.3 0.4 0.00012 22.3 0.4 2.3 3 0 0 3 3 3 1 Bacterial SH3 domain Haspin_kinase PF12330.8 PIK36537.1 - 0.044 12.7 0.0 0.085 11.8 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain TGT PF01702.18 PIK36538.1 - 1.5e-99 333.5 0.4 1.7e-99 333.3 0.4 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase XTBD PF11952.8 PIK36539.1 - 8.1e-25 86.4 0.2 8.7e-25 86.3 0.2 1.0 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD TolA_bind_tri PF16331.5 PIK36540.1 - 0.021 14.9 3.6 0.037 14.1 3.6 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation bZIP_2 PF07716.15 PIK36540.1 - 0.023 14.7 7.2 0.077 13.1 1.4 2.6 1 1 1 2 2 2 0 Basic region leucine zipper Tli4_N PF18443.1 PIK36540.1 - 0.044 14.2 0.8 0.044 14.2 0.8 1.6 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain FTA4 PF13093.6 PIK36540.1 - 0.11 12.3 6.4 0.13 12.2 6.4 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Ank_2 PF12796.7 PIK36541.1 - 2.2e-36 124.3 2.9 3.1e-14 53.3 0.0 2.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK36541.1 - 2.8e-18 66.0 2.4 1.2e-11 44.9 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK36541.1 - 1.4e-16 58.9 0.1 0.00077 19.7 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK36541.1 - 6.9e-14 51.6 0.5 6.2e-05 23.3 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK36541.1 - 1.6e-11 44.2 0.4 4.8e-06 26.7 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DUF1674 PF07896.12 PIK36544.1 - 2.5e-21 75.9 6.0 2.5e-21 75.9 6.0 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1674) I-set PF07679.16 PIK36545.1 - 4.7e-32 109.9 0.2 2e-20 72.7 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK36545.1 - 2.9e-25 88.7 0.2 2.5e-16 60.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK36545.1 - 2.4e-16 59.8 0.0 3.6e-09 36.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK36545.1 - 1.8e-14 53.6 0.5 2.2e-09 37.4 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK36545.1 - 1.5e-06 28.3 0.1 0.00077 19.6 0.0 3.2 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK36545.1 - 6.6e-06 26.4 0.2 0.0024 18.3 0.1 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK36545.1 - 7.3e-05 22.2 0.0 0.028 14.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set PF05790.15 PIK36545.1 - 0.00086 19.5 0.1 0.51 10.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin C2-set domain Ig_4 PF16680.5 PIK36545.1 - 0.0013 18.9 0.0 0.063 13.5 0.0 2.3 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 PIK36545.1 - 0.022 14.8 0.0 3.2 7.8 0.0 2.5 2 1 0 2 2 2 0 C17orf99 Ig domain Izumo-Ig PF16706.5 PIK36545.1 - 0.045 13.8 0.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain FixQ PF05545.11 PIK36545.1 - 0.076 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF3377 PF11857.8 PIK36545.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) SRCR PF00530.18 PIK36546.1 - 1.7e-62 208.1 84.1 4.5e-29 100.9 2.2 8.9 10 0 0 10 10 10 6 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK36546.1 - 4.9e-21 75.1 4.6 1.2e-06 28.9 0.1 5.2 4 0 0 4 4 4 3 Scavenger receptor cysteine-rich domain Furin-like_2 PF15913.5 PIK36546.1 - 1.7e-13 50.7 151.5 9.4e-05 22.5 9.5 9.8 6 4 4 10 10 10 7 Furin-like repeat, cysteine-rich Ig_3 PF13927.6 PIK36546.1 - 2.4e-12 47.3 0.2 6.1e-12 46.0 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK36546.1 - 2.7e-12 46.6 0.0 6.3e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36546.1 - 1e-09 38.6 0.1 5.2e-09 36.3 0.1 2.3 1 0 0 1 1 1 1 Immunoglobulin domain Hepsin-SRCR PF09272.10 PIK36546.1 - 5e-08 33.4 8.2 0.036 14.6 0.0 6.2 6 0 0 6 6 6 3 Hepsin, SRCR domain ig PF00047.25 PIK36546.1 - 1.5e-07 31.5 0.0 3.6e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain VSP PF03302.13 PIK36546.1 - 0.00033 19.6 11.3 0.00033 19.6 11.3 9.1 6 3 3 9 9 9 5 Giardia variant-specific surface protein V-set PF07686.17 PIK36546.1 - 0.00034 20.8 0.3 0.0037 17.4 0.3 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain adh_short PF00106.25 PIK36547.1 - 6.3e-40 136.7 0.0 1.6e-39 135.4 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase MaoC_dehydratas PF01575.19 PIK36547.1 - 1.3e-35 121.7 0.0 2.4e-35 120.8 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain adh_short_C2 PF13561.6 PIK36547.1 - 1.8e-32 112.8 0.1 4.5e-32 111.5 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 PIK36547.1 - 7.9e-19 68.0 0.1 2e-18 66.7 0.1 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 PIK36547.1 - 2.4e-15 56.9 0.6 4.6e-15 56.0 0.2 1.6 2 0 0 2 2 2 1 KR domain MaoC_dehydrat_N PF13452.6 PIK36547.1 - 4.6e-07 30.0 0.0 4.6e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Alkyl_sulf_C PF14864.6 PIK36547.1 - 5.7e-06 26.6 0.1 1.2e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal AA_permease PF00324.21 PIK36548.1 - 1.8e-63 214.8 17.5 1.1e-62 212.2 17.5 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 PIK36548.1 - 8.4e-10 38.0 2.2 8.4e-10 38.0 2.2 2.4 2 1 0 2 2 2 1 Amino acid permease AA_permease_N PF08403.10 PIK36548.1 - 1.3e-07 31.0 0.0 2.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Amino acid permease N-terminal SLC12 PF03522.15 PIK36549.1 - 1e-34 120.3 0.0 1.2e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 PIK36549.1 - 9.7e-28 97.0 7.2 1.2e-27 96.6 7.2 1.1 1 0 0 1 1 1 1 Amino acid permease FA_desaturase PF00487.24 PIK36549.1 - 0.013 15.3 1.5 0.017 15.0 1.5 1.3 1 0 0 1 1 1 0 Fatty acid desaturase DUF3742 PF12553.8 PIK36549.1 - 0.34 11.0 1.9 0.62 10.2 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) Peptidase_C14 PF00656.22 PIK36550.1 - 3.4e-16 60.0 0.0 4.2e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Anoctamin PF04547.12 PIK36551.1 - 2.9e-94 316.5 3.1 3.5e-94 316.2 3.1 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoctamin PF04547.12 PIK36552.1 - 1.9e-139 465.4 12.6 2.4e-139 465.1 12.6 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 PIK36552.1 - 2.9e-37 128.6 0.0 4.8e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Fumarate_red_D PF02313.17 PIK36552.1 - 0.024 14.8 2.6 0.074 13.2 2.6 1.8 1 0 0 1 1 1 0 Fumarate reductase subunit D SseC PF04888.12 PIK36552.1 - 0.12 11.9 0.2 0.18 11.4 0.2 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF4064 PF13273.6 PIK36552.1 - 0.53 10.6 0.0 0.53 10.6 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) UPF0182 PF03699.13 PIK36552.1 - 0.62 8.1 8.9 0.69 8.0 5.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) DUF3084 PF11283.8 PIK36552.1 - 3.4 7.7 8.3 14 5.8 8.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3084) DUF2208 PF09973.9 PIK36552.1 - 5.9 6.4 13.0 0.18 11.4 5.5 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2208) Anoct_dimer PF16178.5 PIK36553.1 - 3e-05 23.9 1.0 3.1e-05 23.8 0.1 1.4 2 0 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Patatin PF01734.22 PIK36554.1 - 5.8e-12 46.2 0.1 7.2e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase NACHT PF05729.12 PIK36555.1 - 2.2e-20 73.2 0.1 4.6e-20 72.2 0.1 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK36555.1 - 5e-07 30.1 0.0 1.7e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK36555.1 - 0.028 13.7 0.1 0.064 12.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 PIK36555.1 - 0.037 13.8 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK36555.1 - 0.042 14.2 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 PIK36555.1 - 0.045 12.9 0.0 0.19 10.9 0.0 2.0 1 1 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 PIK36555.1 - 0.056 12.8 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 KaiC NAD_binding_10 PF13460.6 PIK36557.1 - 3.5e-22 79.2 0.1 4.2e-22 78.9 0.1 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK36557.1 - 9.1e-10 38.5 0.1 1e-09 38.3 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK36557.1 - 1.9e-05 24.2 0.1 2.1e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 PIK36557.1 - 0.01 16.3 0.5 0.03 14.8 0.5 1.9 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DFP PF04127.15 PIK36557.1 - 0.018 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein RmlD_sub_bind PF04321.17 PIK36557.1 - 0.025 13.7 0.0 0.035 13.2 0.0 1.4 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 PIK36557.1 - 0.038 14.1 0.1 0.042 14.0 0.1 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 PIK36557.1 - 0.07 13.4 0.2 0.25 11.6 0.1 1.8 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 PIK36557.1 - 0.16 12.1 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pkinase PF00069.25 PIK36558.1 - 1.1e-11 44.6 0.0 1.7e-11 44.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36558.1 - 0.0017 17.7 0.0 0.005 16.2 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK36558.1 - 0.0018 18.2 0.3 0.005 16.8 0.3 1.6 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK36558.1 - 0.018 13.9 0.0 0.025 13.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 PIK36558.1 - 0.045 13.3 0.0 0.082 12.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 PIK36558.1 - 0.05 13.2 0.0 0.19 11.3 0.0 1.8 1 1 1 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 PIK36558.1 - 0.083 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family OTCace PF00185.24 PIK36559.1 - 2.2e-49 167.5 0.0 3.2e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 PIK36559.1 - 1.6e-42 145.0 0.0 2.4e-42 144.4 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain MPC PF03650.13 PIK36560.1 - 1.2e-39 134.9 0.1 1.6e-39 134.5 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Pkinase PF00069.25 PIK36561.1 - 0.0054 16.1 0.0 0.0082 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Mre11_DNA_bind PF04152.14 PIK36563.1 - 7.7e-50 169.5 0.1 1.4e-49 168.6 0.1 1.5 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 PIK36563.1 - 3.8e-16 60.2 1.5 5.5e-16 59.7 0.8 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK36563.1 - 1.3e-05 25.4 0.0 0.00011 22.4 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mre11_DNA_bind PF04152.14 PIK36564.1 - 1.4e-24 87.3 0.2 1.4e-24 87.3 0.2 1.8 2 1 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 PIK36564.1 - 2.5e-06 28.1 0.1 6.5e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TBSV_P22 PF03558.13 PIK36564.1 - 0.036 13.5 0.0 0.09 12.3 0.0 1.6 2 0 0 2 2 2 0 TBSV core protein P21/P22 Protamine_like PF06382.11 PIK36564.1 - 0.12 12.5 0.1 0.41 10.8 0.1 1.9 2 0 0 2 2 2 0 Protamine and protamine like DUF3899 PF13038.6 PIK36564.1 - 0.18 12.3 0.0 0.66 10.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Kinocilin PF15033.6 PIK36564.1 - 0.2 11.3 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinocilin protein AT_hook PF02178.19 PIK36565.1 - 2 8.6 16.5 3.5e+03 -1.4 16.5 2.9 1 1 0 1 1 1 0 AT hook motif 7tm_1 PF00001.21 PIK36566.1 - 4.1e-22 78.8 5.8 5.8e-22 78.3 5.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36566.1 - 4.5e-06 26.5 11.6 5.6e-06 26.2 11.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK36566.1 - 0.0076 15.7 4.9 0.0099 15.3 4.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK36566.1 - 0.069 12.5 10.4 0.013 14.9 6.4 1.7 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 PIK36567.1 - 2.5e-34 118.8 2.0 2.9e-34 118.6 2.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36567.1 - 8.9e-14 51.7 5.1 1e-13 51.6 5.1 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK36567.1 - 0.00034 20.1 3.0 0.00047 19.6 3.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK36567.1 - 0.007 15.7 2.9 0.008 15.6 2.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv FUSC-like PF12805.7 PIK36567.1 - 1.9 7.5 5.3 3.3 6.7 5.3 1.4 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS SH3_2 PF07653.17 PIK36568.1 - 2e-06 27.3 0.0 3.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK36568.1 - 1.1e-05 24.9 0.2 1.7e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK36568.1 - 4.5e-05 23.2 0.0 7.5e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK36568.1 - 0.0076 16.5 0.2 0.013 15.8 0.2 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_1 PF00018.28 PIK36569.1 - 7.5e-26 89.5 4.1 1.2e-12 47.3 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 PIK36569.1 - 2.1e-21 75.5 1.6 6.5e-13 48.3 0.2 2.4 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 PIK36569.1 - 1.2e-17 63.9 0.0 1.8e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 PIK36569.1 - 4.3e-17 61.5 0.1 7.5e-09 35.1 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 PIK36569.1 - 2.1e-06 27.9 5.8 0.026 14.8 1.5 2.5 2 0 0 2 2 2 2 Bacterial SH3 domain TUDOR_5 PF18359.1 PIK36569.1 - 0.061 13.0 0.0 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain 1 CARD_2 PF16739.5 PIK36570.1 - 0.0037 17.2 0.4 0.0056 16.6 0.4 1.5 1 1 0 1 1 1 1 Caspase recruitment domain CARD PF00619.21 PIK36571.1 - 1.7e-15 56.8 0.1 2.9e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 PIK36571.1 - 0.00012 21.9 0.0 0.0002 21.3 0.0 1.4 1 1 0 1 1 1 1 Caspase recruitment domain NPL PF17800.1 PIK36571.1 - 0.084 13.4 1.5 0.12 12.9 1.5 1.3 1 1 0 1 1 1 0 Nucleoplasmin-like domain EF-hand_14 PF17959.1 PIK36571.1 - 0.22 11.9 1.8 0.34 11.3 1.3 1.6 1 1 0 1 1 1 0 EF-hand domain protein_MS5 PF04776.12 PIK36572.1 - 0.036 14.2 0.2 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein MS5 DUF2087 PF09860.9 PIK36572.1 - 0.17 12.1 0.2 22 5.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) DUF2914 PF11141.8 PIK36572.1 - 0.49 10.2 0.0 0.49 10.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2914) Flu_NS2 PF00601.19 PIK36573.1 - 0.046 14.0 7.8 0.059 13.7 2.2 3.2 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) DUF999 PF06198.11 PIK36573.1 - 0.62 10.0 9.5 5.2 7.1 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF999) SET PF00856.28 PIK36575.1 - 3.3e-09 37.4 0.0 3.3e-09 37.4 0.0 2.7 2 1 0 2 2 2 1 SET domain ATP-synt_F PF01990.17 PIK36576.1 - 0.13 12.6 0.0 8.5 6.8 0.0 2.2 1 1 1 2 2 2 0 ATP synthase (F/14-kDa) subunit zf-Di19 PF05605.12 PIK36578.1 - 2 8.8 6.4 17 5.8 0.9 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Acetyltransf_11 PF13720.6 PIK36579.1 - 0.056 13.9 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Guanylate_kin PF00625.21 PIK36580.1 - 8.4e-49 165.7 0.0 1.1e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase RsgA_GTPase PF03193.16 PIK36580.1 - 0.044 13.7 0.0 0.098 12.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF3931 PF13082.6 PIK36580.1 - 0.88 9.8 3.3 2.4 8.4 1.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3931) RVT_1 PF00078.27 PIK36581.1 - 0.00029 20.4 0.1 0.0006 19.4 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_8 PF13855.6 PIK36582.1 - 0.0064 16.2 0.1 0.017 14.8 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat TRP PF06011.12 PIK36582.1 - 0.81 8.3 7.7 0.081 11.6 1.7 2.0 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Ig_3 PF13927.6 PIK36583.1 - 1.3e-08 35.4 2.2 0.15 12.7 0.0 4.6 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK36583.1 - 2e-08 34.4 0.5 0.014 15.6 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK36583.1 - 7.3e-07 29.2 0.4 0.00043 20.3 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK36583.1 - 0.0021 18.2 3.4 1.5 9.0 0.0 4.4 4 1 0 4 4 4 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK36583.1 - 0.0031 17.6 0.1 0.76 9.9 0.0 3.1 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 PIK36583.1 - 0.0034 17.7 4.4 1.2 9.5 0.0 5.0 5 2 0 5 5 5 1 Immunoglobulin domain Sigma_reg_N PF13800.6 PIK36583.1 - 0.027 14.8 1.3 0.06 13.6 1.3 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal PRD1_DD PF11087.8 PIK36583.1 - 3.9 7.2 7.9 9.1 6.1 7.9 1.5 1 0 0 1 1 1 0 PRD1 phage membrane DNA delivery Pkinase PF00069.25 PIK36584.1 - 1.9e-71 240.5 0.0 2.6e-71 240.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36584.1 - 7.1e-35 120.5 0.1 5.9e-34 117.5 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK36584.1 - 2.3e-06 27.1 0.0 0.00016 21.1 0.0 2.4 1 1 1 2 2 2 2 Kinase-like RnlA_toxin PF15935.5 PIK36584.1 - 0.0035 17.1 0.1 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 RNase LS, bacterial toxin MAPEG PF01124.18 PIK36585.1 - 7.2e-19 68.0 0.1 1.3e-18 67.1 0.1 1.4 1 0 0 1 1 1 1 MAPEG family DAD PF02109.16 PIK36585.1 - 0.086 13.2 1.4 0.61 10.4 0.1 2.7 2 1 0 2 2 2 0 DAD family DUF2162 PF09930.9 PIK36585.1 - 1.9 7.9 9.5 1.3 8.4 6.1 2.4 2 1 0 2 2 2 0 Predicted transporter (DUF2162) UBA_4 PF14555.6 PIK36586.1 - 2.9e-10 39.8 0.5 9.8e-10 38.1 0.3 2.0 2 0 0 2 2 2 1 UBA-like domain Exo_endo_phos PF03372.23 PIK36586.1 - 3.1e-06 26.9 0.0 7.7e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TAP_C PF03943.13 PIK36586.1 - 0.00043 19.9 0.1 0.00091 18.8 0.1 1.5 1 0 0 1 1 1 1 TAP C-terminal domain Glyco_transf_92 PF01697.27 PIK36587.1 - 3.2e-19 69.6 0.4 5e-19 69.0 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 PIK36587.1 - 2.6e-07 31.1 0.5 5.6e-07 30.0 0.5 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 RVT_1 PF00078.27 PIK36588.1 - 4e-37 127.9 0.1 6.4e-37 127.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RinB PF06116.12 PIK36589.1 - 0.17 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Transcriptional activator RinB RT_RNaseH_2 PF17919.1 PIK36591.1 - 3.4e-18 65.5 0.0 5.5e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36591.1 - 2.2e-07 30.6 0.0 3.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK36591.1 - 2.2e-07 31.1 0.0 3.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Bac_surface_Ag PF01103.23 PIK36592.1 - 0.0004 20.0 0.9 0.00051 19.6 0.9 1.2 1 0 0 1 1 1 1 Surface antigen Ribosomal_S5 PF00333.20 PIK36592.1 - 0.019 14.9 0.2 0.034 14.1 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain UPF0113 PF03657.13 PIK36593.1 - 1.8e-22 79.4 0.0 2.1e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 PIK36593.1 - 0.0036 17.2 0.0 0.0044 17.0 0.0 1.1 1 0 0 1 1 1 1 PUA domain CCDC23 PF15674.5 PIK36594.1 - 1.5e-07 31.3 15.3 1.5e-07 31.3 15.3 3.3 4 0 0 4 4 4 1 Coiled-coil domain-containing protein 23 DUF4094 PF13334.6 PIK36594.1 - 3 8.3 9.2 0.73 10.3 3.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) ubiquitin PF00240.23 PIK36595.1 - 0.00052 19.7 0.0 0.0007 19.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Peptidase_M14 PF00246.24 PIK36597.1 - 1.1e-30 107.5 0.0 3e-19 69.9 0.0 2.1 2 0 0 2 2 2 2 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK36597.1 - 6.9e-11 42.4 0.1 1.3e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase activation peptide tRNA_deacylase PF04414.12 PIK36597.1 - 0.051 13.1 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase DUF872 PF05915.12 PIK36598.1 - 7.8e-21 74.4 0.0 9.4e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) S_4TM PF18159.1 PIK36598.1 - 0.0078 15.5 0.4 0.0098 15.2 0.4 1.1 1 0 0 1 1 1 1 SMODS-associating 4TM effector domain DUF3040 PF11239.8 PIK36598.1 - 0.011 16.0 1.2 0.02 15.2 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) RDD PF06271.12 PIK36598.1 - 0.035 14.3 3.0 0.05 13.8 3.0 1.2 1 0 0 1 1 1 0 RDD family DUF4131 PF13567.6 PIK36598.1 - 0.055 13.1 0.6 0.082 12.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF373 PF04123.13 PIK36598.1 - 0.084 12.3 1.5 0.1 12.0 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2207 PF09972.9 PIK36598.1 - 0.087 11.6 0.0 0.1 11.3 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) BatD PF13584.6 PIK36598.1 - 0.12 11.2 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance Saf_2TM PF18303.1 PIK36598.1 - 5.7 6.5 6.4 3.9 7.1 0.2 2.2 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain UFD1 PF03152.14 PIK36599.1 - 5e-16 58.7 0.0 5.7e-08 32.4 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin fusion degradation protein UFD1 TPMT PF05724.11 PIK36600.1 - 1.9e-42 145.4 0.0 2.2e-42 145.2 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 PIK36600.1 - 0.0021 17.9 0.0 0.0028 17.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK36600.1 - 0.03 15.0 0.0 0.24 12.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36600.1 - 0.1 13.3 0.0 0.36 11.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain adh_short PF00106.25 PIK36601.1 - 2.6e-31 108.6 0.0 2.7e-30 105.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK36601.1 - 8e-21 74.7 0.0 8.2e-20 71.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK36601.1 - 3.9e-05 23.6 0.1 6.3e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 KR domain AAT PF03417.16 PIK36601.1 - 0.13 12.0 0.3 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Sacchrp_dh_NADP PF03435.18 PIK36601.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Glyco_transf_4 PF13439.6 PIK36601.1 - 0.17 11.9 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Piwi PF02171.17 PIK36602.1 - 3.1e-84 282.8 0.4 6.1e-84 281.8 0.0 1.7 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.22 PIK36602.1 - 6.6e-33 113.4 1.1 1.2e-32 112.5 1.1 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 PIK36602.1 - 6e-06 25.8 0.0 5.4e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Argonaute linker 1 domain MCU PF04678.13 PIK36603.1 - 2.7e-48 164.4 3.1 3.4e-48 164.1 3.1 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter ELO PF01151.18 PIK36603.1 - 0.041 13.4 0.5 0.063 12.8 0.5 1.3 1 0 0 1 1 1 0 GNS1/SUR4 family DUF981 PF06168.11 PIK36603.1 - 0.049 13.6 0.7 0.059 13.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF981) EF-hand_1 PF00036.32 PIK36605.1 - 5.3e-05 22.5 0.9 0.00019 20.8 0.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 PIK36605.1 - 5.5e-05 22.5 0.7 5.5e-05 22.5 0.7 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK36605.1 - 0.0001 21.9 0.3 0.00042 20.0 0.3 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 PIK36605.1 - 0.0013 19.2 0.2 0.0058 17.1 0.2 2.2 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK36605.1 - 0.0027 17.5 0.9 0.085 12.7 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK36606.1 - 5.2e-07 29.4 0.1 1.1e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK36606.1 - 8.6e-05 21.8 0.2 0.00041 19.7 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK36606.1 - 0.0002 21.1 0.0 0.00084 19.1 0.0 2.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 PIK36606.1 - 0.0095 15.4 0.8 0.017 14.6 0.1 1.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK36606.1 - 0.021 15.3 0.2 0.049 14.1 0.2 1.6 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_4 PF12763.7 PIK36606.1 - 0.085 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 PIK36606.1 - 0.18 12.2 0.0 2.1 8.7 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain zf-CCHC PF00098.23 PIK36607.1 - 1.9e-07 30.8 15.8 0.00046 20.1 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK36607.1 - 0.00036 20.3 8.1 0.07 13.0 3.8 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK36607.1 - 0.0021 18.0 12.7 0.18 11.8 1.3 3.3 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK36607.1 - 0.012 15.3 11.1 3.5 7.4 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36607.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK36607.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger RVT_1 PF00078.27 PIK36608.1 - 8.2e-18 64.7 0.0 3.3e-10 39.8 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF596 PF04591.12 PIK36608.1 - 0.16 12.2 0.7 0.61 10.3 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF596 Retrotran_gag_2 PF14223.6 PIK36609.1 - 1.8e-20 73.0 0.0 2.7e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DIX PF00778.17 PIK36609.1 - 0.12 12.3 0.1 0.27 11.1 0.1 1.6 1 0 0 1 1 1 0 DIX domain MFS_1 PF07690.16 PIK36611.1 - 1.4e-33 116.3 40.7 2e-29 102.6 29.2 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK36611.1 - 1.4e-05 24.2 34.4 0.0095 14.8 9.2 3.6 2 2 1 3 3 3 3 Sugar (and other) transporter LapA_dom PF06305.11 PIK36611.1 - 0.19 11.6 0.4 2.4 8.1 0.0 3.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Borrelia_P13 PF05628.12 PIK36611.1 - 1.1 9.2 5.9 0.15 12.0 1.1 1.9 2 0 0 2 2 2 0 Borrelia membrane protein P13 VIT1 PF01988.19 PIK36611.1 - 3.2 7.5 8.5 2.4 8.0 1.3 2.5 2 0 0 2 2 2 0 VIT family DUF4097 PF13349.6 PIK36612.1 - 4.9e-09 35.9 8.9 1.8e-08 34.1 8.9 1.8 1 1 0 1 1 1 1 Putative adhesin COesterase PF00135.28 PIK36613.1 - 2.2e-84 284.2 0.0 3e-84 283.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK36613.1 - 0.00068 19.6 0.1 0.17 11.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK36614.1 - 3.1e-55 188.0 0.0 3.7e-55 187.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family I-set PF07679.16 PIK36615.1 - 8.9e-31 105.8 0.2 1.6e-10 40.9 0.0 5.1 4 1 1 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK36615.1 - 1.4e-30 105.7 1.8 1.1e-11 45.1 0.0 5.2 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK36615.1 - 1.5e-24 86.1 1.4 4.7e-09 36.4 0.0 4.6 4 1 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK36615.1 - 4e-21 75.0 4.0 2.7e-06 27.5 0.1 5.1 4 1 1 5 5 5 3 Immunoglobulin domain V-set PF07686.17 PIK36615.1 - 2.5e-14 53.4 3.1 1e-05 25.6 0.0 4.8 3 3 0 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK36615.1 - 3.8e-07 30.4 0.1 1.3 9.5 0.0 3.5 3 0 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK36615.1 - 6.2e-07 28.9 0.0 0.7 9.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Izumo-Ig PF16706.5 PIK36615.1 - 0.00071 19.6 0.1 16 5.6 0.0 3.7 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK36615.1 - 0.0019 18.4 0.3 5 7.5 0.0 3.4 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set PF05790.15 PIK36615.1 - 0.059 13.6 0.8 3.2 8.0 0.1 3.4 4 0 0 4 4 4 0 Immunoglobulin C2-set domain I-set PF07679.16 PIK36616.1 - 1.9e-15 56.7 0.0 1.4e-13 50.7 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK36616.1 - 3.3e-15 56.4 0.0 1.3e-12 48.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK36616.1 - 2.7e-08 34.0 0.0 1.3e-07 31.8 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK36616.1 - 3.7e-05 23.8 0.0 0.00028 21.0 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK36616.1 - 0.00075 19.7 0.2 0.14 12.4 0.2 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_C17orf99 PF17736.1 PIK36616.1 - 0.081 13.0 0.0 0.27 11.3 0.0 1.8 1 1 0 1 1 1 0 C17orf99 Ig domain Pou PF00157.17 PIK36617.1 - 1.8e-28 98.3 0.1 4.3e-28 97.1 0.1 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK36617.1 - 1.4e-15 56.9 0.8 4.1e-15 55.4 0.8 1.9 1 0 0 1 1 1 1 Homeodomain HOCHOB PF17943.1 PIK36617.1 - 0.02 15.6 0.0 0.039 14.7 0.0 1.5 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox HTH_31 PF13560.6 PIK36617.1 - 0.028 14.8 0.0 0.075 13.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HisG_C PF08029.11 PIK36617.1 - 0.11 12.7 0.4 35 4.6 0.2 3.1 3 0 0 3 3 3 0 HisG, C-terminal domain Homeobox_KN PF05920.11 PIK36617.1 - 0.13 12.2 0.0 0.51 10.3 0.0 2.0 1 0 0 1 1 1 0 Homeobox KN domain Shugoshin_C PF07557.11 PIK36618.1 - 4.4e-08 32.8 4.6 8e-08 31.9 4.6 1.5 1 0 0 1 1 1 1 Shugoshin C terminus BBL5 PF07289.11 PIK36621.1 - 1.4e-100 336.6 0.0 1.7e-100 336.4 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein bPH_3 PF14470.6 PIK36621.1 - 0.064 13.6 0.0 0.097 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain GRAM PF02893.20 PIK36621.1 - 0.08 12.8 0.1 0.32 10.9 0.1 1.9 1 1 1 2 2 2 0 GRAM domain BBL5 PF07289.11 PIK36622.1 - 1e-11 44.5 0.0 1.1e-11 44.4 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein CBS PF00571.28 PIK36623.1 - 1.1e-16 61.0 0.3 5.1e-11 42.9 0.2 2.3 2 0 0 2 2 2 2 CBS domain CBS PF00571.28 PIK36624.1 - 2.8e-11 43.7 3.9 0.00013 22.4 3.5 2.3 1 1 1 2 2 2 2 CBS domain Glyco_transf_21 PF13506.6 PIK36624.1 - 0.18 11.3 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 RVT_1 PF00078.27 PIK36625.1 - 1.7e-11 44.1 0.0 3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK36625.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK36626.1 - 2e-21 76.4 0.0 4.6e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK36626.1 - 2.2e-20 72.9 0.2 6.3e-20 71.4 0.2 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK36626.1 - 2e-19 69.4 0.8 5.2e-19 68.1 0.8 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK36626.1 - 5e-10 39.3 0.1 1.4e-09 37.9 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK36626.1 - 0.014 15.2 0.0 0.039 13.7 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.10 PIK36626.1 - 0.025 14.8 0.1 0.059 13.6 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger DUF5332 PF17266.2 PIK36626.1 - 0.047 13.4 1.0 1 9.0 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5332) Fer4_4 PF12800.7 PIK36626.1 - 1 10.0 10.3 4.4 8.1 2.5 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Ig_3 PF13927.6 PIK36628.1 - 1.4e-09 38.4 1.1 0.0002 21.9 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK36628.1 - 1.1e-07 31.8 1.1 0.0032 17.5 0.2 3.1 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK36628.1 - 1.2e-05 25.4 0.5 0.0019 18.3 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK36628.1 - 0.00024 21.3 0.0 0.0013 18.9 0.1 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK36628.1 - 0.011 16.1 0.8 3.9 7.9 0.0 3.1 2 2 1 3 3 3 0 Immunoglobulin domain Ig_6 PF18452.1 PIK36628.1 - 0.06 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK36629.1 - 1.5e-29 103.1 0.0 3.2e-29 102.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36629.1 - 1.9e-13 50.4 0.0 2.2e-12 46.9 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain I-set PF07679.16 PIK36629.1 - 0.0085 16.1 0.1 0.017 15.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Pkinase_Tyr PF07714.17 PIK36630.1 - 1e-57 195.4 0.0 1.5e-57 194.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36630.1 - 5.4e-23 81.7 0.0 8.7e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 PIK36630.1 - 0.0065 15.5 0.1 0.013 14.5 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK36630.1 - 0.066 13.1 1.2 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family RT_RNaseH_2 PF17919.1 PIK36633.1 - 1.6e-39 134.0 0.0 2.1e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36633.1 - 7.1e-31 106.6 0.0 1e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MATalpha_HMGbox PF04769.12 PIK36633.1 - 0.07 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box DUF5597 PF18120.1 PIK36633.1 - 0.086 13.0 0.0 0.16 12.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5597) RVT_1 PF00078.27 PIK36634.1 - 1.8e-10 40.7 0.0 3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1722 PF08349.11 PIK36634.1 - 0.057 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) rve PF00665.26 PIK36635.1 - 7.3e-21 74.6 0.0 1.1e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK36635.1 - 0.0026 17.5 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK36635.1 - 0.003 17.8 0.1 0.021 15.1 0.0 1.9 2 0 0 2 2 2 1 DDE domain DUF5395 PF17373.2 PIK36635.1 - 0.099 13.3 0.1 0.22 12.2 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5395) Rpp20 PF12328.8 PIK36635.1 - 0.13 12.3 0.2 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Cys_box PF17869.1 PIK36635.1 - 0.14 12.3 0.1 0.32 11.1 0.1 1.6 1 0 0 1 1 1 0 Anosmin cysteine rich domain IL17R_fnIII_D1 PF16556.5 PIK36636.1 - 0.046 13.4 0.1 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Interleukin-17 receptor, fibronectin-III-like domain 1 DUF4713 PF15831.5 PIK36636.1 - 0.58 10.6 12.0 1.1 9.7 12.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) zf-TRAF PF02176.18 PIK36637.1 - 3.4e-09 37.3 2.8 6.9e-09 36.3 2.8 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger Spectrin PF00435.21 PIK36637.1 - 0.0023 18.4 7.5 0.017 15.6 0.2 2.4 1 1 1 2 2 2 1 Spectrin repeat Sina PF03145.16 PIK36637.1 - 0.029 14.3 0.7 0.049 13.6 0.7 1.3 1 0 0 1 1 1 0 Seven in absentia protein family Trimer_CC PF08954.11 PIK36637.1 - 0.037 13.6 11.4 0.097 12.2 0.2 3.8 2 2 1 3 3 3 0 Trimerisation motif FlxA PF14282.6 PIK36637.1 - 0.051 13.6 14.5 0.057 13.4 8.4 2.5 1 1 1 2 2 2 0 FlxA-like protein Allexi_40kDa PF05549.11 PIK36637.1 - 0.061 12.8 4.2 0.11 11.9 2.2 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein zf-TRAF_2 PF15965.5 PIK36637.1 - 0.063 13.7 1.4 0.16 12.5 1.4 1.6 1 0 0 1 1 1 0 TRAF-like zinc-finger COG5 PF10392.9 PIK36637.1 - 0.083 13.1 2.4 0.11 12.7 0.5 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 BLOC1_2 PF10046.9 PIK36637.1 - 0.13 12.6 12.3 0.61 10.4 5.2 3.3 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PspB PF06667.12 PIK36637.1 - 0.29 11.2 3.7 5.7 7.1 1.1 3.0 3 0 0 3 3 3 0 Phage shock protein B Fib_alpha PF08702.10 PIK36637.1 - 0.36 11.0 8.7 0.29 11.3 5.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KASH_CCD PF14662.6 PIK36637.1 - 0.42 10.4 10.7 1.5 8.6 10.6 1.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 PIK36637.1 - 0.56 9.0 10.3 0.81 8.5 10.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.12 PIK36637.1 - 0.85 9.6 7.7 0.97 9.4 6.5 1.6 1 1 0 1 1 1 0 Laminin Domain II DASH_Spc19 PF08287.11 PIK36637.1 - 1.1 9.1 12.8 1.6 8.6 4.3 2.8 1 1 2 3 3 3 0 Spc19 DUF1515 PF07439.11 PIK36637.1 - 1.2 9.2 4.8 1.4 9.0 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF948 PF06103.11 PIK36637.1 - 1.3 9.3 10.4 1.1 9.5 5.4 2.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 PIK36637.1 - 1.7 9.1 9.7 4.6 7.7 2.2 3.1 2 1 1 3 3 3 0 Syntaxin-like protein DUF1690 PF07956.11 PIK36637.1 - 1.7 9.0 11.7 2 8.8 4.2 2.4 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) DUF4407 PF14362.6 PIK36637.1 - 3.3 7.0 9.8 4.7 6.5 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 PIK36637.1 - 3.8 8.0 8.1 96 3.5 0.6 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 PIK36637.1 - 4.2 7.8 9.0 4.3 7.7 0.0 3.9 3 1 1 5 5 5 0 TSC-22/dip/bun family DUF1664 PF07889.12 PIK36637.1 - 5.5 7.1 10.5 6.8 6.8 4.8 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 PIK36637.1 - 6.6 7.3 12.1 4.4e+02 1.4 12.1 2.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Lebercilin PF15619.6 PIK36637.1 - 8.4 6.0 16.0 4.2 7.0 12.0 2.3 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2428 PF10350.9 PIK36638.1 - 7.8e-47 159.8 7.6 7.8e-47 159.8 4.8 2.5 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 PIK36638.1 - 0.024 14.9 1.6 1.9 9.0 0.0 5.0 5 1 1 6 6 6 0 HEAT repeat HEAT_2 PF13646.6 PIK36638.1 - 0.16 12.4 0.1 7.9 6.9 0.0 3.7 3 1 1 4 4 4 0 HEAT repeats Peptidase_C65 PF10275.9 PIK36640.1 - 1.3e-80 270.4 0.2 1.6e-80 270.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 PIK36640.1 - 1.5e-05 25.4 0.1 0.00052 20.5 0.1 2.3 1 1 0 1 1 1 1 OTU-like cysteine protease Methyltransf_16 PF10294.9 PIK36641.1 - 1.8e-12 47.4 0.0 2.7e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 PIK36641.1 - 0.011 16.4 0.0 0.027 15.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36641.1 - 0.048 14.4 0.0 0.098 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_1 PF00036.32 PIK36642.1 - 1.3e-25 87.0 18.5 1e-06 27.8 0.1 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 PIK36642.1 - 4.2e-24 84.8 5.3 1.4e-13 51.0 0.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK36642.1 - 1.3e-20 71.5 10.0 3e-05 23.6 0.4 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK36642.1 - 1.2e-19 68.9 10.4 9.5e-05 21.7 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 PIK36642.1 - 7.5e-15 54.5 11.7 0.0009 19.0 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK36642.1 - 1e-07 32.3 0.4 0.0031 17.8 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK36642.1 - 7.7e-07 29.0 6.4 0.0015 18.4 0.4 3.7 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 PIK36642.1 - 0.0027 18.0 0.2 0.094 13.1 0.0 2.6 2 1 1 3 3 3 1 EF-hand domain Caleosin PF05042.13 PIK36642.1 - 0.015 15.3 3.2 6.3 6.7 0.1 3.5 2 2 2 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.18 PIK36642.1 - 0.48 10.6 3.7 3.1 8.1 1.0 2.9 3 1 1 4 4 4 0 Dockerin type I domain ANAPC1 PF12859.7 PIK36643.1 - 0.0047 17.5 7.4 0.022 15.3 0.3 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 PIK36644.1 - 0.00012 22.3 13.5 1.1 9.8 0.1 4.8 4 0 0 4 4 4 3 Proteasome/cyclosome repeat APC1_C PF18122.1 PIK36645.1 - 8.9e-24 84.3 0.9 1.4e-23 83.6 0.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain EHD_N PF16880.5 PIK36646.1 - 1.5e-13 50.4 1.5 2.6e-13 49.6 1.5 1.3 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 PIK36646.1 - 3.3e-05 24.0 0.0 6.1e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK36646.1 - 8.8e-05 22.6 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 PIK36646.1 - 0.0043 16.4 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 PIK36646.1 - 0.19 11.3 0.2 0.55 9.7 0.2 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1488 PF07369.11 PIK36646.1 - 0.24 11.4 0.9 1.1 9.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) Dynein_C PF18199.1 PIK36647.1 - 1.2e-89 300.5 0.0 4.4e-89 298.7 0.0 1.9 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 PIK36647.1 - 2.9e-53 180.0 0.0 5e-53 179.3 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK36647.1 - 1.6e-39 134.7 0.0 3.7e-39 133.5 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 PIK36648.1 - 3.8e-91 305.0 0.0 7.7e-91 304.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK36648.1 - 3.1e-85 284.8 0.1 1e-84 283.1 0.1 2.0 1 0 0 1 1 1 1 ATP-binding dynein motor region MT PF12777.7 PIK36648.1 - 3.9e-47 161.0 5.8 6.3e-47 160.3 5.8 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_1 PF17857.1 PIK36648.1 - 0.036 14.3 0.7 0.16 12.2 0.1 2.5 2 0 0 2 2 2 0 AAA+ lid domain AAA_22 PF13401.6 PIK36648.1 - 0.043 14.1 1.9 0.45 10.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain DUF3417 PF11897.8 PIK36648.1 - 1.1 9.8 3.3 16 6.0 0.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3417) DUF745 PF05335.13 PIK36648.1 - 1.3 8.7 13.1 4.7 6.9 3.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Rootletin PF15035.6 PIK36648.1 - 4.3 7.3 14.3 3.5 7.6 2.1 2.7 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.11 PIK36648.1 - 5.1 5.9 23.4 0.18 10.7 1.6 2.7 3 0 0 3 3 3 0 Spc7 kinetochore protein LUC7 PF03194.15 PIK36648.1 - 5.5 6.6 14.5 0.74 9.4 2.3 2.6 3 0 0 3 3 3 0 LUC7 N_terminus DUF848 PF05852.11 PIK36648.1 - 5.8 7.0 10.0 14 5.7 0.5 3.1 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF148 PF02520.17 PIK36648.1 - 6 7.0 11.4 5.6 7.1 3.4 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF148 CBS PF00571.28 PIK36649.1 - 9.9e-28 96.4 8.1 8e-11 42.2 0.9 3.5 4 0 0 4 4 4 3 CBS domain Herpes_capsid PF06112.11 PIK36649.1 - 4.8 7.2 8.7 8.6 6.4 8.7 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Laminin_EGF PF00053.24 PIK36650.1 - 3.9e-77 254.2 229.6 8.9e-09 35.4 15.6 14.5 12 2 1 13 13 13 13 Laminin EGF domain Laminin_N PF00055.17 PIK36650.1 - 2.1e-39 135.5 1.1 2.1e-39 135.5 1.1 3.3 3 1 0 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK36650.1 - 1.5e-11 44.3 0.0 4.5e-11 42.8 0.0 1.9 1 0 0 1 1 1 1 Laminin B (Domain IV) POTRA_TamA_1 PF17243.2 PIK36650.1 - 0.79 9.9 2.4 1.5 9.0 0.2 2.7 2 0 0 2 2 2 0 POTRA domain TamA domain 1 Peptidase_M16_C PF05193.21 PIK36651.1 - 3.4e-34 118.4 0.0 5.1e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain GlutR_dimer PF00745.20 PIK36651.1 - 0.11 13.0 0.2 0.22 12.0 0.2 1.5 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain p450 PF00067.22 PIK36652.1 - 7.6e-108 361.2 0.0 8.9e-108 361.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4455 PF14643.6 PIK36653.1 - 1.1e-157 525.5 34.4 1.1e-157 525.5 34.4 4.0 3 1 1 4 4 4 3 Domain of unknown function (DUF4455) DUF4456 PF14644.6 PIK36653.1 - 5.4e-61 205.9 6.8 5.4e-61 205.9 6.8 5.0 5 2 1 6 6 6 1 Domain of unknown function (DUF4456) DUF5329 PF17263.2 PIK36653.1 - 0.057 13.6 0.1 0.24 11.6 0.1 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5329) DUF4806 PF16064.5 PIK36653.1 - 0.11 12.8 0.3 13 6.2 0.2 3.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4806) IL17 PF06083.11 PIK36654.1 - 2.3e-24 85.6 2.1 4.2e-24 84.8 2.1 1.4 1 0 0 1 1 1 1 Interleukin-17 zf-3CxxC_2 PF17180.4 PIK36655.1 - 3e-28 98.3 10.2 3.6e-28 98.1 10.2 1.1 1 0 0 1 1 1 1 Zinc-binding domain UPF0515 PF15135.6 PIK36655.1 - 7.4e-05 22.2 5.3 8.5e-05 22.0 5.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC PF13695.6 PIK36655.1 - 0.00016 22.1 14.7 0.014 15.9 14.7 2.6 1 1 0 1 1 1 1 Zinc-binding domain Cytochrom_c3_2 PF14537.6 PIK36655.1 - 0.013 15.9 4.4 0.019 15.4 4.4 1.2 1 0 0 1 1 1 0 Cytochrome c3 zf-CHY PF05495.12 PIK36655.1 - 0.024 15.1 9.1 0.045 14.2 1.9 2.1 2 0 0 2 2 2 0 CHY zinc finger Tachystatin_B PF11478.8 PIK36655.1 - 1.2 9.2 6.9 7.4 6.6 1.5 2.4 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B zf_UBZ PF18439.1 PIK36655.1 - 7.4 6.3 9.6 8.9 6.0 0.4 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger PKD_channel PF08016.12 PIK36656.1 - 1.9e-155 517.7 15.7 1.9e-155 517.7 15.7 1.7 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 PIK36656.1 - 1.5e-25 89.9 30.0 5.3e-25 88.1 26.4 2.1 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.32 PIK36656.1 - 1.4e-06 27.4 0.5 0.099 12.2 0.2 3.0 2 0 0 2 2 2 2 EF hand Fer4_24 PF18109.1 PIK36656.1 - 0.00033 20.8 0.1 0.00082 19.6 0.1 1.7 1 0 0 1 1 1 1 Ferredoxin I 4Fe-4S cluster domain EF-hand_6 PF13405.6 PIK36656.1 - 0.00056 19.6 0.4 0.72 9.9 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 PIK36656.1 - 0.0058 17.0 0.8 0.022 15.2 0.7 2.1 1 1 0 1 1 1 1 EF-hand domain pair Sulfotransfer_2 PF03567.14 PIK36659.1 - 1.4e-24 87.4 1.3 8.1e-23 81.6 1.3 2.4 1 1 0 1 1 1 1 Sulfotransferase family DUF1996 PF09362.10 PIK36660.1 - 1 9.3 6.3 0.6 10.1 0.8 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF1996) VWD PF00094.25 PIK36661.1 - 3.9e-11 43.5 0.0 2.2e-10 41.0 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type D domain EGF_3 PF12947.7 PIK36661.1 - 0.00025 21.2 1.1 0.00054 20.1 1.1 1.6 1 0 0 1 1 1 1 EGF domain AMOP PF03782.17 PIK36661.1 - 0.067 13.3 2.9 0.11 12.6 2.9 1.4 1 0 0 1 1 1 0 AMOP domain NIDO PF06119.14 PIK36661.1 - 0.12 13.3 0.0 0.3 12.0 0.0 1.7 1 0 0 1 1 1 0 Nidogen-like EGF_CA PF07645.15 PIK36662.1 - 5.8e-30 103.2 41.6 2.3e-11 43.7 4.6 4.3 4 0 0 4 4 4 4 Calcium-binding EGF domain EGF_3 PF12947.7 PIK36662.1 - 2.1e-15 56.6 32.7 8.3e-07 29.1 7.8 4.6 3 1 1 4 4 4 4 EGF domain cEGF PF12662.7 PIK36662.1 - 6.6e-15 54.7 23.5 1.3e-06 28.2 3.2 4.5 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF PF00008.27 PIK36662.1 - 5.6e-10 39.3 39.0 3e-05 24.2 9.1 4.6 4 1 0 4 4 4 3 EGF-like domain EGF_MSP1_1 PF12946.7 PIK36662.1 - 7.6e-06 25.9 20.5 1.2e-05 25.3 4.7 3.8 3 0 0 3 3 3 2 MSP1 EGF domain 1 FXa_inhibition PF14670.6 PIK36662.1 - 0.00067 19.9 32.9 0.73 10.2 10.8 4.1 1 1 2 3 3 3 3 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK36662.1 - 0.0028 18.2 37.3 0.045 14.4 4.8 5.0 5 0 0 5 5 5 3 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK36662.1 - 0.064 13.6 30.3 0.27 11.6 5.0 3.8 4 0 0 4 4 4 0 Pvs28 EGF domain EGF_2 PF07974.13 PIK36662.1 - 0.15 12.5 29.8 0.3 11.5 2.9 4.3 2 2 0 3 3 3 0 EGF-like domain EB PF01683.18 PIK36662.1 - 1.9 8.8 40.7 0.35 11.2 6.1 4.3 1 1 3 4 4 4 0 EB module TMIE PF16038.5 PIK36663.1 - 0.25 11.2 1.1 0.51 10.2 1.1 1.4 1 0 0 1 1 1 0 TMIE protein RRM_1 PF00076.22 PIK36664.1 - 2.9e-23 81.5 0.3 8.4e-14 51.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36664.1 - 2.9e-08 33.7 0.3 0.0022 18.1 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK36664.1 - 0.21 11.7 0.4 31 4.7 0.1 2.8 2 1 0 2 2 2 0 RNA binding motif RRM_1 PF00076.22 PIK36665.1 - 2.8e-26 91.1 0.4 1.2e-13 50.7 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36665.1 - 2.4e-09 37.2 0.0 1.3e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK36665.1 - 0.00022 21.2 0.8 8.4 6.5 0.0 3.2 3 0 0 3 3 3 3 RNA binding motif NCBP3 PF10309.9 PIK36665.1 - 0.0035 17.2 0.0 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 RL PF17797.1 PIK36665.1 - 0.033 14.1 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 RL domain PHM7_cyt PF14703.6 PIK36665.1 - 0.18 12.0 0.5 3.8 7.7 0.0 2.3 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 PIK36666.1 - 6.6e-15 54.7 0.0 9.3e-15 54.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36666.1 - 0.0098 16.0 0.0 0.027 14.6 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 PIK36666.1 - 0.013 15.6 0.1 0.023 14.7 0.1 1.4 1 1 0 1 1 1 0 RNA binding motif SieB PF14163.6 PIK36666.1 - 0.045 13.3 0.5 0.061 12.8 0.5 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B OB_RNB PF08206.11 PIK36666.1 - 0.072 12.8 0.1 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_1 PF00076.22 PIK36667.1 - 8e-18 64.0 0.1 1.6e-11 43.8 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK36667.1 - 0.011 15.8 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif Phage_holin_3_6 PF07332.11 PIK36668.1 - 6.9 6.8 13.8 14 5.7 0.1 3.8 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III ORC2 PF04084.14 PIK36669.1 - 4.7e-99 331.5 3.2 6.7e-99 330.9 3.2 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 BSP_II PF05432.11 PIK36669.1 - 1.2 8.7 13.0 2 8.0 13.0 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) cwf18 PF08315.12 PIK36670.1 - 0.025 15.2 5.1 0.03 15.0 5.1 1.1 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor TMEM247 PF15444.6 PIK36670.1 - 0.25 11.4 5.1 0.29 11.2 5.1 1.0 1 0 0 1 1 1 0 Transmembrane protein 247 SAPS PF04499.15 PIK36670.1 - 2.3 6.9 9.0 2.3 6.9 9.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4637 PF15470.6 PIK36670.1 - 2.5 7.8 8.2 3.1 7.5 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) GREB1 PF15782.5 PIK36670.1 - 3.6 4.6 8.3 3.9 4.5 8.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Arcadin_1 PF18653.1 PIK36671.1 - 0.053 13.6 1.8 0.12 12.4 1.8 1.6 1 0 0 1 1 1 0 Arcadin 1 MENTAL PF10457.9 PIK36673.1 - 1.4e-14 54.3 0.1 2.3e-14 53.6 0.1 1.3 1 0 0 1 1 1 1 Cholesterol-capturing domain START PF01852.19 PIK36673.1 - 0.00015 21.3 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 START domain DUF2852 PF11014.8 PIK36673.1 - 0.13 12.4 0.1 0.42 10.8 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) SSF PF00474.17 PIK36674.1 - 8e-12 44.7 8.0 1.1e-11 44.3 8.0 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family IGR PF09597.10 PIK36675.1 - 0.043 13.9 0.8 12 6.1 0.2 3.1 3 0 0 3 3 3 0 IGR protein motif Peptidase_U49 PF10463.9 PIK36675.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase U49 SPICE PF15678.5 PIK36676.1 - 2.4e-41 142.4 19.6 8.6e-33 114.3 5.0 3.1 2 1 1 3 3 3 2 Centriole duplication and mitotic chromosome congression POLO_box PF00659.18 PIK36677.1 - 1.3e-38 131.0 1.2 1.3e-20 73.4 0.1 2.5 2 0 0 2 2 2 2 POLO box duplicated region Hexapep_loop PF18776.1 PIK36678.1 - 0.00056 19.5 6.3 82 3.0 0.0 8.5 4 3 1 7 7 7 0 Hexapeptide repeat including loop CfAFP PF05264.11 PIK36678.1 - 0.0041 17.1 1.2 0.092 12.7 0.5 2.6 2 1 1 3 3 3 1 Choristoneura fumiferana antifreeze protein (CfAFP) Peptidase_M26_N PF05342.14 PIK36678.1 - 0.55 9.6 6.5 4.6 6.6 0.2 3.0 2 1 1 3 3 3 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region 7tm_2 PF00002.24 PIK36679.1 - 7.2e-24 84.4 0.3 9e-24 84.1 0.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Fibrinogen_C PF00147.18 PIK36680.1 - 5.5e-46 157.1 2.2 5.5e-46 157.1 2.2 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK36680.1 - 4.6e-07 29.7 24.5 3.4e-05 23.7 3.9 3.3 2 1 1 3 3 3 2 TILa domain EGF_3 PF12947.7 PIK36680.1 - 2.3e-05 24.5 43.9 0.00033 20.8 11.3 4.5 3 2 2 5 5 5 2 EGF domain EGF_MSP1_1 PF12946.7 PIK36680.1 - 0.0015 18.6 22.2 0.0017 18.4 4.5 3.2 3 0 0 3 3 3 2 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK36680.1 - 1.5 9.3 42.2 0.11 12.8 6.3 4.6 3 2 0 3 3 3 0 EGF-like domain Patched PF02460.18 PIK36681.1 - 2.2e-153 512.3 31.7 3.7e-107 359.4 4.1 3.0 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 PIK36681.1 - 1.3e-43 148.5 7.4 1.3e-43 148.5 7.4 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK36681.1 - 0.0022 17.0 4.9 0.0022 17.0 4.9 2.4 2 1 0 2 2 2 1 MMPL family Acetyltransf_10 PF13673.7 PIK36682.1 - 3.9e-08 33.3 0.0 7.7e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 PIK36682.1 - 5.7e-07 29.4 0.0 2.9e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK36682.1 - 0.0001 22.5 0.0 0.0027 17.9 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family YEATS PF03366.16 PIK36685.1 - 1.1e-11 44.5 0.1 3.7e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 YEATS family DUF3114 PF11311.8 PIK36685.1 - 0.016 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) Rad54_N PF08658.10 PIK36685.1 - 0.023 14.9 1.2 0.044 14.0 1.2 1.4 1 0 0 1 1 1 0 Rad54 N terminal Noggin PF05806.12 PIK36685.1 - 0.62 9.9 2.3 5.9 6.7 0.1 2.1 1 1 1 2 2 2 0 Noggin MEA1 PF06910.11 PIK36685.1 - 2 9.1 4.9 0.47 11.1 1.3 1.7 2 0 0 2 2 2 0 Male enhanced antigen 1 (MEA1) MFS_1 PF07690.16 PIK36686.1 - 3.1e-34 118.5 37.0 1.8e-27 96.2 11.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Collectrin PF16959.5 PIK36686.1 - 0.15 11.9 1.3 0.49 10.2 0.9 2.0 2 0 0 2 2 2 0 Renal amino acid transporter DUF3040 PF11239.8 PIK36687.1 - 0.03 14.6 0.6 0.063 13.6 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) 7tm_1 PF00001.21 PIK36688.1 - 1.5e-37 129.3 18.2 1.9e-37 129.0 18.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36688.1 - 1.1e-13 51.4 12.3 1.1e-13 51.4 12.3 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK36688.1 - 7.6e-05 22.2 11.0 0.00012 21.6 10.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK36688.1 - 0.00075 19.0 17.1 0.0019 17.6 17.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 PIK36688.1 - 0.0052 16.6 10.8 0.0052 16.6 10.8 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Shisa PF13908.6 PIK36688.1 - 0.6 10.3 3.9 1 9.6 3.2 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator RT_RNaseH_2 PF17919.1 PIK36689.1 - 2.8e-31 107.5 0.1 4.6e-31 106.8 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36689.1 - 1.7e-20 73.3 0.0 3.1e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK36689.1 - 2.3e-06 27.3 0.0 3.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK36690.1 - 8.8e-05 22.1 0.0 0.00022 20.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK36690.1 - 0.0022 18.0 1.5 0.0022 18.0 1.5 3.0 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 PIK36690.1 - 0.021 15.2 0.7 0.021 15.2 0.7 2.7 1 1 2 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G Sec3_C PF09763.9 PIK36690.1 - 0.19 10.1 1.6 0.25 9.7 1.6 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 zf-CCCH_7 PF18586.1 PIK36690.1 - 0.35 11.2 6.3 0.078 13.3 1.6 2.3 2 1 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 zf-CCHC_5 PF14787.6 PIK36690.1 - 0.58 9.9 14.0 0.087 12.5 4.1 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK36690.1 - 6.8 6.8 10.5 0.99 9.4 2.3 2.7 2 0 0 2 2 2 0 Zinc knuckle 7tm_1 PF00001.21 PIK36691.1 - 2.3e-16 59.9 5.6 2.9e-16 59.6 5.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK36691.1 - 4.1e-06 26.4 4.6 6e-06 25.8 4.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK36691.1 - 0.00015 21.5 8.7 0.00019 21.2 8.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK36693.1 - 1.5e-43 149.0 15.6 2e-43 148.6 15.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36693.1 - 1.9e-11 44.1 11.4 4.3e-11 43.0 11.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK36693.1 - 2.9e-08 33.4 3.4 2.9e-08 33.4 3.4 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK36693.1 - 3.6e-07 29.8 9.5 4.9e-07 29.4 9.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TMEM192 PF14802.6 PIK36693.1 - 0.029 13.5 0.6 0.11 11.6 0.1 2.1 1 1 1 2 2 2 0 TMEM192 family 7tm_1 PF00001.21 PIK36694.1 - 8.2e-29 100.7 8.3 1e-28 100.4 8.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36694.1 - 3.4e-12 46.6 7.1 4.2e-12 46.3 7.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK36694.1 - 0.00054 19.4 7.2 0.00077 18.9 7.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK36694.1 - 0.00088 18.7 0.9 0.00088 18.7 0.9 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 PIK36695.1 - 3.4e-25 88.9 10.8 4.4e-25 88.5 10.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK36695.1 - 1.1e-10 41.6 7.7 1.4e-10 41.3 7.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK36695.1 - 0.00035 20.0 5.2 0.00045 19.7 5.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DHHC PF01529.20 PIK36695.1 - 0.099 12.7 7.2 0.65 10.1 0.3 2.7 2 1 0 2 2 2 0 DHHC palmitoyltransferase rve PF00665.26 PIK36696.1 - 3.7e-22 78.7 0.1 4.7e-22 78.4 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36696.1 - 3.6e-10 39.8 3.0 9e-10 38.5 2.3 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK36696.1 - 9.8e-05 22.1 0.0 0.00027 20.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK36696.1 - 0.0036 17.5 1.7 0.005 17.0 0.3 2.0 2 0 0 2 2 2 1 H2C2 zinc finger An_peroxidase PF03098.15 PIK36697.1 - 8e-175 582.4 0.0 9.8e-175 582.1 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 PIK36698.1 - 2.6e-166 554.3 0.0 3.8e-166 553.8 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase PT PF04886.12 PIK36698.1 - 2.3e-06 27.0 43.5 3.6 7.2 0.2 8.4 3 2 0 3 3 3 2 PT repeat TFIIA PF03153.13 PIK36698.1 - 0.15 12.0 2.2 0.23 11.4 2.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit S1 PF00575.23 PIK36699.1 - 3.7e-18 65.6 0.1 7e-18 64.7 0.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 PIK36699.1 - 1.6e-15 57.2 0.0 2.7e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 PIK36699.1 - 1.3e-05 25.4 0.0 2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Clat_adaptor_s PF01217.20 PIK36700.1 - 2.4e-62 209.1 6.0 2.6e-62 208.9 6.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RhoGAP PF00620.27 PIK36701.1 - 0.00014 21.7 0.0 0.00042 20.2 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PNMA PF14893.6 PIK36702.1 - 2.9e-10 40.0 1.2 2.9e-10 40.0 1.2 1.6 1 1 1 2 2 2 1 PNMA zf-CCHC PF00098.23 PIK36702.1 - 3.2e-05 23.8 2.0 5.1e-05 23.2 2.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36702.1 - 0.0094 15.8 0.9 0.016 15.1 0.9 1.4 1 0 0 1 1 1 1 Zinc knuckle DUF3097 PF11296.8 PIK36702.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) SLATT_6 PF18169.1 PIK36702.1 - 0.074 12.6 0.1 0.16 11.5 0.1 1.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 eIF3g PF12353.8 PIK36702.1 - 0.077 13.4 0.9 0.21 12.0 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G RVT_1 PF00078.27 PIK36703.1 - 7.5e-32 110.6 0.0 1.2e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK36703.1 - 1.3e-28 98.9 0.0 2.6e-27 94.8 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36703.1 - 8.4e-25 87.1 0.0 1.5e-23 83.1 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK36703.1 - 2.5e-17 62.7 1.9 4.8e-17 61.8 1.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK36703.1 - 3e-14 53.2 0.0 5.8e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK36703.1 - 0.05 13.8 0.3 0.13 12.5 0.3 1.7 1 0 0 1 1 1 0 H2C2 zinc finger TMEM223 PF14640.6 PIK36705.1 - 4.1e-57 192.9 0.0 4.9e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 zf-CCHH PF10283.9 PIK36706.1 - 2.7e-21 75.2 16.5 7.1e-11 41.9 7.7 2.4 2 0 0 2 2 2 2 PBZ domain FHA_2 PF17913.1 PIK36706.1 - 6.9e-05 23.0 0.0 0.00013 22.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 PIK36706.1 - 0.00013 22.3 0.0 0.00025 21.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-CCCH PF00642.24 PIK36706.1 - 3.3 7.7 6.7 12 6.0 1.0 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HUN PF08729.10 PIK36706.1 - 6.4 6.9 18.8 0.13 12.3 8.7 3.1 2 0 0 2 2 2 0 HPC2 and ubinuclein domain DUF4570 PF15134.6 PIK36707.1 - 4.5e-16 58.8 3.7 4.8e-16 58.7 3.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) DUF382 PF04037.13 PIK36708.1 - 2.4e-55 186.1 3.3 2.4e-55 186.1 3.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 PIK36708.1 - 2e-20 72.4 2.9 2e-20 72.4 2.9 1.8 2 0 0 2 2 2 1 PSP RNA_pol_Rpc4 PF05132.14 PIK36708.1 - 4.9 7.6 16.7 7.9 6.9 3.9 3.7 4 0 0 4 4 4 0 RNA polymerase III RPC4 SAP PF02037.27 PIK36709.1 - 7.6e-11 41.5 0.5 1.5e-10 40.6 0.5 1.5 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 PIK36709.1 - 0.0036 17.0 1.2 0.0068 16.1 1.2 1.5 1 0 0 1 1 1 1 HeH/LEM domain EMC3_TMCO1 PF01956.16 PIK36709.1 - 4.9 6.9 7.4 8.8 6.0 7.4 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Ribosomal_L11 PF00298.19 PIK36710.1 - 2.1e-27 95.4 0.2 4.1e-27 94.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 PIK36710.1 - 6.3e-25 86.8 0.1 1.1e-24 86.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Styelin PF17562.2 PIK36710.1 - 0.00019 21.7 0.1 0.85 10.0 0.0 3.2 3 0 0 3 3 3 2 Styelin Methyltransf_31 PF13847.6 PIK36711.1 - 2.7e-26 92.2 0.0 3.6e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK36711.1 - 4.8e-18 65.6 0.0 8.5e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36711.1 - 3.7e-16 59.5 0.0 6.5e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK36711.1 - 4.7e-16 59.1 0.0 6.8e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36711.1 - 5e-13 49.6 0.0 7.6e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK36711.1 - 1.6e-10 40.8 0.0 2.5e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 PIK36711.1 - 8e-09 35.2 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 PIK36711.1 - 8.2e-06 25.5 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 PIK36711.1 - 1.7e-05 24.3 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK36711.1 - 9.1e-05 22.3 0.0 0.0003 20.6 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 PIK36711.1 - 0.00031 20.1 0.0 0.00045 19.6 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_2 PF00891.18 PIK36711.1 - 0.0005 19.4 0.0 0.0007 18.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 PIK36711.1 - 0.0014 18.5 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 PIK36711.1 - 0.0015 18.0 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 PIK36711.1 - 0.0069 15.8 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 PIK36711.1 - 0.0072 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.19 PIK36711.1 - 0.031 14.4 0.0 0.045 13.9 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF938 PF06080.12 PIK36711.1 - 0.037 13.8 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) tRNA_U5-meth_tr PF05958.11 PIK36711.1 - 0.051 12.6 0.0 0.075 12.0 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.6 PIK36711.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 PIK36711.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Pox_MCEL PF03291.16 PIK36711.1 - 0.23 10.5 0.0 0.3 10.2 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme zf-RING_UBOX PF13445.6 PIK36712.1 - 1.1e-08 34.9 7.9 1.1e-08 34.9 7.9 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK36712.1 - 3.2e-08 33.3 10.1 3.2e-08 33.3 10.1 4.0 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK36712.1 - 3.5e-08 33.5 24.3 3.6e-07 30.2 7.9 4.5 4 1 0 4 4 3 2 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK36712.1 - 6.2e-08 32.4 6.5 6.2e-08 32.4 6.5 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK36712.1 - 2e-07 31.2 9.5 2e-07 31.2 9.5 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK36712.1 - 5.4e-07 29.3 10.1 5.4e-07 29.3 10.1 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK36712.1 - 2.9e-06 27.1 9.2 2.9e-06 27.1 9.2 3.6 3 0 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK36712.1 - 0.00012 22.1 9.2 0.00012 22.1 9.2 3.9 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK36712.1 - 0.0049 16.7 7.3 0.0049 16.7 7.3 3.8 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 GIT1_C PF12205.8 PIK36712.1 - 0.0082 16.2 1.1 0.025 14.7 1.1 1.8 1 0 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term zf-ANAPC11 PF12861.7 PIK36712.1 - 0.011 15.7 1.5 0.048 13.7 1.5 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Muted PF14942.6 PIK36712.1 - 0.015 15.7 4.2 0.037 14.4 4.2 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Apolipoprotein PF01442.18 PIK36712.1 - 0.23 11.3 8.5 0.53 10.1 8.6 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain RYDR_ITPR PF01365.21 PIK36712.1 - 1.6 8.1 10.3 0.42 10.0 0.1 2.9 2 1 0 3 3 3 0 RIH domain SAYSvFN PF10260.9 PIK36713.1 - 2.9e-27 94.4 0.1 4.2e-27 93.9 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) DUF2417 PF10329.9 PIK36713.1 - 0.089 12.2 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) FMN_dh PF01070.18 PIK36714.1 - 8e-87 291.5 0.2 9e-87 291.3 0.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK36714.1 - 5.4e-08 32.2 0.3 7.1e-08 31.8 0.3 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK36714.1 - 5.3e-05 22.5 0.2 7.1e-05 22.1 0.2 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 PIK36714.1 - 0.0036 16.6 2.0 0.4 9.9 0.1 2.4 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 PIK36714.1 - 0.0063 15.9 0.0 3.6 7.0 0.0 2.3 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator His_biosynth PF00977.21 PIK36714.1 - 0.0068 15.9 0.7 0.012 15.1 0.0 1.7 3 0 0 3 3 3 1 Histidine biosynthesis protein NMO PF03060.15 PIK36714.1 - 0.016 14.6 1.4 0.024 14.0 1.4 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase PA PF02225.22 PIK36714.1 - 0.057 13.4 0.7 3.2 7.8 0.0 2.7 2 1 1 3 3 3 0 PA domain Fe-ADH PF00465.19 PIK36715.1 - 1.9e-105 352.6 0.0 2.2e-105 352.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 PIK36715.1 - 7.9e-15 55.2 0.0 3.4e-11 43.3 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 PIK36715.1 - 0.0039 16.9 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein IRS PF02174.17 PIK36716.1 - 2.7e-27 94.6 0.2 6.9e-27 93.3 0.1 1.7 2 0 0 2 2 2 1 PTB domain (IRS-1 type) Peptidase_S9_N PF02897.15 PIK36717.1 - 7.1e-143 476.3 0.0 9.1e-143 476.0 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 PIK36717.1 - 1.9e-59 200.7 0.0 3e-59 200.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 PIK36717.1 - 0.074 11.7 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Ras PF00071.22 PIK36718.1 - 2.2e-41 141.2 0.0 2.8e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK36718.1 - 7.1e-20 71.4 0.0 1e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK36718.1 - 7e-10 38.6 0.0 8.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK36718.1 - 3.3e-05 23.4 0.0 5.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 PIK36718.1 - 7.3e-05 22.4 0.0 0.00059 19.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK36718.1 - 0.0011 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK36718.1 - 0.0064 15.9 0.0 0.009 15.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 PIK36718.1 - 0.0076 16.2 0.0 0.46 10.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 PIK36718.1 - 0.022 14.5 0.2 0.064 13.0 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Methyltransf_23 PF13489.6 PIK36719.1 - 7.1e-08 32.5 0.2 9.5e-06 25.5 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK36719.1 - 1.3e-07 32.2 0.1 3.5e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36719.1 - 2.8e-07 31.2 0.1 4.7e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK36719.1 - 2.1e-06 28.3 0.0 5.6e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 PIK36719.1 - 6.4e-06 25.8 0.0 9.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 PIK36719.1 - 7.2e-06 25.9 0.0 9.9e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK36719.1 - 0.00012 21.6 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 PIK36719.1 - 0.00092 18.2 0.0 0.0017 17.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 PIK36719.1 - 0.0021 17.5 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 PIK36719.1 - 0.013 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_18 PF12847.7 PIK36719.1 - 0.017 15.0 1.1 0.022 14.7 0.3 1.5 2 0 0 2 2 2 0 Methyltransferase domain DUF4723 PF15851.5 PIK36720.1 - 0.0021 18.2 0.0 0.0046 17.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4723) Ndc80_HEC PF03801.13 PIK36721.1 - 3.8e-38 130.5 0.6 8.8e-38 129.3 0.6 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family APG6_N PF17675.1 PIK36721.1 - 1.2e-07 32.4 19.6 0.00028 21.4 14.7 2.6 1 1 1 2 2 2 2 Apg6 coiled-coil region DUF5595 PF18077.1 PIK36721.1 - 8.8e-06 25.7 0.7 8.8e-06 25.7 0.7 3.6 3 1 0 3 3 3 1 Domain of unknown function (DUF5595) GAS PF13851.6 PIK36721.1 - 0.02 14.2 16.1 0.041 13.2 16.1 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RecG_N PF17190.4 PIK36721.1 - 0.059 14.1 1.1 0.059 14.1 1.1 3.3 2 1 1 3 3 3 0 RecG N-terminal helical domain rve_3 PF13683.6 PIK36721.1 - 0.064 13.0 0.7 4 7.3 0.4 2.5 2 0 0 2 2 2 0 Integrase core domain DUF4200 PF13863.6 PIK36721.1 - 0.36 11.2 20.5 2.4 8.6 12.4 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Streptin-Immun PF11083.8 PIK36721.1 - 0.48 10.9 7.0 1.3 9.5 5.6 2.4 1 1 0 1 1 1 0 Lantibiotic streptin immunity protein VSG_B PF13206.6 PIK36721.1 - 0.95 8.7 5.3 1.4 8.0 5.3 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain LMBR1 PF04791.16 PIK36721.1 - 2.1 7.2 4.7 3 6.6 4.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MA3 PF02847.17 PIK36722.1 - 0.0078 16.2 1.7 0.011 15.7 1.7 1.3 1 1 0 1 1 1 1 MA3 domain Endonuc-dimeris PF09124.10 PIK36722.1 - 0.017 15.2 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation MetRS-N PF09635.10 PIK36722.1 - 0.03 14.9 0.4 0.036 14.6 0.4 1.2 1 0 0 1 1 1 0 MetRS-N binding domain NusB PF01029.18 PIK36722.1 - 0.041 14.1 0.4 0.042 14.1 0.4 1.0 1 0 0 1 1 1 0 NusB family LMBR1 PF04791.16 PIK36722.1 - 0.13 11.2 1.2 0.15 11.0 1.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein HLH PF00010.26 PIK36724.1 - 3.4e-10 39.7 1.6 7.2e-10 38.7 0.9 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain APG6_N PF17675.1 PIK36724.1 - 0.0033 18.0 3.8 0.0033 18.0 3.8 1.6 2 0 0 2 2 2 1 Apg6 coiled-coil region DivIC PF04977.15 PIK36724.1 - 0.0045 16.7 0.6 0.014 15.2 0.6 1.8 1 0 0 1 1 1 1 Septum formation initiator ZapB PF06005.12 PIK36724.1 - 0.01 16.2 1.6 0.01 16.2 1.6 2.3 3 0 0 3 3 3 0 Cell division protein ZapB Hrs_helical PF12210.8 PIK36724.1 - 0.026 15.1 0.3 0.069 13.7 0.3 1.7 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Spc7 PF08317.11 PIK36724.1 - 0.028 13.3 4.7 0.046 12.6 4.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.11 PIK36724.1 - 0.041 11.9 3.7 0.047 11.6 3.7 1.1 1 0 0 1 1 1 0 Prominin Snapin_Pallidin PF14712.6 PIK36724.1 - 0.045 14.2 1.2 0.045 14.2 1.2 1.9 2 0 0 2 2 2 0 Snapin/Pallidin Cnn_1N PF07989.11 PIK36724.1 - 0.16 12.1 3.1 0.14 12.4 0.6 2.1 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Seryl_tRNA_N PF02403.22 PIK36724.1 - 1.6 9.0 8.1 1.3 9.3 4.1 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain THOC7 PF05615.13 PIK36724.1 - 4.3 7.6 10.9 0.14 12.5 0.8 2.7 2 1 1 3 3 3 0 Tho complex subunit 7 Peptidase_S64 PF08192.11 PIK36724.1 - 5.7 5.3 13.2 7.2 5.0 13.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 SMC_N PF02463.19 PIK36725.1 - 1.2e-50 172.0 43.0 3.7e-49 167.1 43.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK36725.1 - 4.1e-27 94.8 0.1 1.5e-26 93.0 0.1 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 PIK36725.1 - 1.4e-11 45.3 16.4 3e-11 44.2 10.5 7.8 2 2 2 4 4 4 2 AAA domain AAA_21 PF13304.6 PIK36725.1 - 3.9e-10 40.0 0.3 1.3e-05 25.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK36725.1 - 0.00021 21.0 0.0 0.00045 19.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 PIK36725.1 - 0.00025 20.9 83.6 0.0018 18.0 47.2 4.7 2 2 1 3 3 3 2 AAA ATPase domain ABC_tran PF00005.27 PIK36725.1 - 0.68 10.5 0.0 0.68 10.5 0.0 6.6 3 2 1 5 5 5 0 ABC transporter Ig_3 PF13927.6 PIK36726.1 - 9.2e-20 71.0 1.8 2.6e-12 47.2 1.4 3.8 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK36726.1 - 1.1e-18 67.1 1.7 3.4e-12 46.3 0.3 3.0 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK36726.1 - 2.3e-12 47.1 5.4 3.8e-09 36.8 1.8 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK36726.1 - 9.7e-11 41.8 4.6 0.021 15.0 1.6 4.2 3 1 0 3 3 3 3 Immunoglobulin V-set domain ig PF00047.25 PIK36726.1 - 4.5e-09 36.3 7.5 1.9e-05 24.7 1.7 3.5 3 1 0 3 3 3 2 Immunoglobulin domain TIR_2 PF13676.6 PIK36726.1 - 6e-08 33.3 0.0 2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 PIK36726.1 - 1.4e-07 31.5 0.1 2.4e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 TIR domain Ig_5 PF16681.5 PIK36726.1 - 0.00044 20.6 1.8 0.0024 18.2 0.6 2.8 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK36726.1 - 0.00087 19.5 2.6 0.015 15.6 0.9 3.1 2 1 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK36726.1 - 0.0012 18.9 0.5 0.76 9.9 0.2 3.0 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK36726.1 - 0.036 13.8 6.4 0.14 11.9 1.7 3.4 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 C1-set PF07654.15 PIK36726.1 - 0.088 13.2 1.2 0.28 11.6 1.2 1.9 1 0 0 1 1 1 0 Immunoglobulin C1-set domain BiPBP_C PF06832.12 PIK36726.1 - 0.14 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family BACON PF13004.7 PIK36726.1 - 0.24 11.4 1.5 1.5 8.9 0.3 2.5 2 0 0 2 2 2 0 Putative binding domain, N-terminal WD40 PF00400.32 PIK36727.1 - 7.7e-05 23.4 2.7 0.0075 17.1 1.1 2.6 2 1 0 2 2 2 1 WD domain, G-beta repeat Hira PF07569.11 PIK36727.1 - 0.019 14.7 0.2 5.9 6.6 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split zf-C2HC5 PF06221.13 PIK36727.1 - 0.52 10.3 4.6 1.2 9.2 0.3 2.9 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type AAA PF00004.29 PIK36728.1 - 3.1e-40 137.7 0.0 5.5e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK36728.1 - 2.5e-15 56.0 0.2 5e-14 51.8 0.2 2.5 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 PIK36728.1 - 2.2e-10 40.4 0.1 7.9e-10 38.6 0.0 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 PIK36728.1 - 2e-06 28.0 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 PIK36728.1 - 8.9e-06 25.5 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 PIK36728.1 - 0.00016 21.8 0.0 0.00038 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK36728.1 - 0.0002 21.4 0.1 0.0013 18.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 PIK36728.1 - 0.00053 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 PIK36728.1 - 0.00059 20.3 0.1 0.015 15.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 PIK36728.1 - 0.00071 19.0 0.1 0.0015 17.9 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 PIK36728.1 - 0.0037 17.0 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 PIK36728.1 - 0.0043 17.1 0.0 0.0098 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK36728.1 - 0.0071 15.9 0.2 0.017 14.6 0.2 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK36728.1 - 0.0077 16.5 0.9 0.079 13.2 0.2 2.7 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 PIK36728.1 - 0.0079 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 PIK36728.1 - 0.0084 16.0 0.2 0.057 13.3 0.1 2.3 2 1 0 2 2 1 1 NACHT domain AAA_18 PF13238.6 PIK36728.1 - 0.016 15.7 0.7 0.078 13.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 PIK36728.1 - 0.038 13.3 0.1 2.2 7.6 0.1 2.5 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 PIK36728.1 - 0.056 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 PIK36728.1 - 0.071 13.4 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK36728.1 - 0.072 13.5 0.1 0.27 11.6 0.0 2.1 2 0 0 2 2 1 0 RNA helicase AAA_17 PF13207.6 PIK36728.1 - 0.093 13.2 0.7 0.32 11.4 0.1 2.2 2 0 0 2 2 1 0 AAA domain Ribosomal_L12 PF00542.19 PIK36728.1 - 0.11 12.9 0.3 1.6 9.1 0.1 2.6 3 0 0 3 3 2 0 Ribosomal protein L7/L12 C-terminal domain AAA_24 PF13479.6 PIK36728.1 - 0.14 11.9 1.0 0.33 10.6 0.2 2.0 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 PIK36728.1 - 0.15 11.7 0.0 0.57 9.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 PIK36728.1 - 0.18 11.5 1.0 0.25 11.0 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK36728.1 - 0.23 11.0 0.3 0.63 9.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain Gal-3-0_sulfotr PF06990.11 PIK36729.1 - 1.5e-43 149.2 1.0 2.2e-43 148.7 1.0 1.3 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK36729.1 - 0.0044 17.0 10.0 0.082 12.8 10.0 2.4 1 1 0 1 1 1 1 Sulfotransferase family Glyco_transf_10 PF00852.19 PIK36730.1 - 3.5e-49 166.9 0.1 5.9e-49 166.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK36730.1 - 0.00019 21.8 0.1 0.00048 20.5 0.1 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Mlh1_C PF16413.5 PIK36731.1 - 2.7e-74 250.0 0.0 5.4e-74 249.0 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 PIK36731.1 - 8e-36 122.3 0.4 1.3e-35 121.6 0.4 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 PIK36731.1 - 1.6e-12 47.4 0.4 3.9e-12 46.2 0.2 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK36731.1 - 1.6e-06 28.6 0.0 3.5e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cystatin PF00031.21 PIK36732.1 - 5.4e-14 52.2 0.6 6e-14 52.1 0.6 1.1 1 0 0 1 1 1 1 Cystatin domain Dynein_light PF01221.18 PIK36732.1 - 0.021 15.1 1.5 0.075 13.4 1.5 1.8 1 1 0 1 1 1 0 Dynein light chain type 1 AKNA PF12443.8 PIK36732.1 - 0.11 13.2 0.0 0.15 12.7 0.0 1.2 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF445 PF04286.12 PIK36732.1 - 0.14 11.9 0.0 0.15 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Tubulin_C PF03953.17 PIK36732.1 - 0.17 12.0 0.2 1.6 8.9 0.0 2.0 1 1 1 2 2 2 0 Tubulin C-terminal domain DUF5132 PF17195.4 PIK36732.1 - 0.23 11.6 2.2 0.32 11.1 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF5132) Sulfotransfer_3 PF13469.6 PIK36733.1 - 4.8e-05 23.9 0.2 0.00057 20.3 0.0 2.4 2 1 1 3 3 3 1 Sulfotransferase family Glyco_transf_92 PF01697.27 PIK36734.1 - 3.1e-15 56.5 0.2 4.5e-15 56.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 PIK36734.1 - 5.7e-07 30.0 0.8 1.5e-06 28.7 0.8 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 UBA_4 PF14555.6 PIK36735.1 - 2.7e-10 39.9 0.6 6.4e-10 38.7 0.3 1.7 2 0 0 2 2 2 1 UBA-like domain Exo_endo_phos PF03372.23 PIK36735.1 - 9.5e-05 22.0 0.0 0.00016 21.3 0.0 1.4 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family TAP_C PF03943.13 PIK36735.1 - 0.00031 20.3 0.1 0.00059 19.4 0.1 1.4 1 0 0 1 1 1 1 TAP C-terminal domain MAPEG PF01124.18 PIK36736.1 - 3e-19 69.2 0.3 3.7e-19 68.9 0.3 1.1 1 0 0 1 1 1 1 MAPEG family DAD PF02109.16 PIK36736.1 - 0.026 14.8 1.2 0.22 11.8 0.1 2.6 2 1 0 2 2 2 0 DAD family GpcrRhopsn4 PF10192.9 PIK36738.1 - 1.6e-25 90.0 11.3 1.9e-25 89.7 11.3 1.0 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain PelG PF16933.5 PIK36738.1 - 0.032 13.1 12.0 0.04 12.8 12.0 1.1 1 0 0 1 1 1 0 Putative exopolysaccharide Exporter (EPS-E) HPP PF04982.13 PIK36738.1 - 0.045 13.9 1.5 0.44 10.8 0.2 2.4 2 0 0 2 2 2 0 HPP family DUF2407_C PF13373.6 PIK36738.1 - 0.063 13.4 0.4 0.091 12.9 0.4 1.4 1 1 0 1 1 1 0 DUF2407 C-terminal domain DUF1146 PF06612.11 PIK36738.1 - 0.16 12.0 0.2 0.16 12.0 0.2 2.9 4 1 0 4 4 4 0 Protein of unknown function (DUF1146) DUF2070 PF09843.9 PIK36738.1 - 0.3 9.3 9.6 0.35 9.1 9.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) NHL PF01436.21 PIK36739.1 - 2.6e-33 112.4 12.6 2e-06 27.5 0.1 6.6 6 0 0 6 6 6 5 NHL repeat SGL PF08450.12 PIK36739.1 - 1.9e-14 53.9 0.4 0.0026 17.4 0.0 5.1 1 1 4 5 5 5 4 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 PIK36739.1 - 5.7e-09 35.6 2.1 0.12 11.5 0.0 4.2 4 0 0 4 4 4 3 6-bladed beta-propeller Arylesterase PF01731.20 PIK36739.1 - 3e-05 24.1 0.0 4.3 7.6 0.0 4.5 4 1 1 5 5 5 1 Arylesterase Filamin PF00630.19 PIK36739.1 - 3.6e-05 24.5 0.0 0.00013 22.8 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat SdiA-regulated PF06977.11 PIK36739.1 - 0.00019 20.8 0.0 0.8 8.9 0.0 3.5 1 1 1 3 3 3 1 SdiA-regulated SBBP PF06739.11 PIK36739.1 - 0.00046 20.1 4.8 0.0044 17.0 0.1 4.1 4 0 0 4 4 4 1 Beta-propeller repeat Phytase-like PF13449.6 PIK36739.1 - 0.0023 17.9 0.0 6.9 6.5 0.0 3.6 2 1 2 4 4 4 2 Esterase-like activity of phytase Str_synth PF03088.16 PIK36739.1 - 0.0062 16.6 0.1 0.86 9.8 0.0 3.9 3 2 2 5 5 5 1 Strictosidine synthase DUF4934 PF16288.5 PIK36739.1 - 0.034 14.1 0.1 1.1 9.2 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4934) Invasin_D3 PF09134.10 PIK36739.1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Invasin, domain 3 Lactonase PF10282.9 PIK36739.1 - 0.076 12.3 0.0 0.28 10.4 0.0 1.9 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ThylakoidFormat PF11264.8 PIK36739.1 - 0.077 12.7 0.2 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 Thylakoid formation protein DUF839 PF05787.13 PIK36739.1 - 0.11 11.6 0.4 17 4.4 0.0 2.9 1 1 2 4 4 4 0 Bacterial protein of unknown function (DUF839) DUF3342 PF11822.8 PIK36739.1 - 0.19 12.0 0.2 1.2 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Ank_2 PF12796.7 PIK36740.1 - 2.4e-15 56.9 0.4 7.4e-08 32.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK36740.1 - 3.7e-11 42.2 0.3 0.00027 21.1 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 PIK36740.1 - 1.7e-10 41.2 0.6 0.0013 19.3 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK36740.1 - 2e-10 40.7 1.0 2e-07 31.1 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK36740.1 - 2e-09 37.5 0.5 0.018 15.5 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat PUFD PF16553.5 PIK36740.1 - 2.3e-07 30.9 0.0 7.7e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain DUF4994 PF16385.5 PIK36741.1 - 7e-06 25.9 1.1 8.7 6.3 0.0 6.4 1 1 6 8 8 8 2 Domain of unknown function Reductase_C PF14759.6 PIK36741.1 - 0.00019 21.9 1.5 1.3e+02 3.2 0.0 7.3 1 1 6 8 8 8 0 Reductase C-terminal Jiraiya PF15038.6 PIK36742.1 - 0.0049 16.3 0.0 0.0067 15.9 0.0 1.2 1 0 0 1 1 1 1 Jiraiya Troponin-I_N PF11636.8 PIK36742.1 - 1.7 8.7 6.3 1.8 8.5 0.9 2.2 2 0 0 2 2 2 0 Troponin I residues 1-32 MFS_1 PF07690.16 PIK36743.1 - 2.5e-30 105.6 26.2 1.3e-17 63.8 20.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 PIK36743.1 - 1.8e-08 34.1 15.0 8.6e-07 28.6 13.5 2.0 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Pox_P21 PF05313.12 PIK36743.1 - 0.029 14.0 3.0 1.6 8.3 2.6 2.3 2 0 0 2 2 2 0 Poxvirus P21 membrane protein DUF4131 PF13567.6 PIK36743.1 - 2.4 7.8 15.7 5.6 6.6 0.3 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) C12orf66_like PF09404.10 PIK36744.1 - 6.5e-41 140.6 0.0 7.8e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like CK_II_beta PF01214.18 PIK36745.1 - 7.5e-24 84.5 0.0 8.3e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CK_II_beta PF01214.18 PIK36746.1 - 1.8e-43 148.4 1.6 2.2e-43 148.2 1.6 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Rotamase PF00639.21 PIK36747.1 - 1.9e-21 76.8 0.0 2.4e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 PIK36747.1 - 9e-17 61.7 0.0 1.1e-16 61.4 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 PIK36747.1 - 1.1e-05 25.4 1.1 1.8e-05 24.7 0.1 1.8 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 PIK36747.1 - 0.036 14.9 0.0 0.046 14.6 0.0 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain Glyco_hyd_101C PF17451.2 PIK36747.1 - 0.097 13.0 0.2 0.25 11.6 0.1 1.6 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain X8 PF07983.13 PIK36747.1 - 0.17 12.6 0.0 0.29 11.8 0.0 1.4 1 0 0 1 1 1 0 X8 domain GH3 PF03321.13 PIK36748.1 - 3.9e-124 415.4 3.7 4.6e-124 415.1 3.7 1.1 1 0 0 1 1 1 1 GH3 auxin-responsive promoter GH3 PF03321.13 PIK36749.1 - 1.1e-91 308.3 0.1 1.4e-91 308.0 0.1 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Activator-TraM PF11657.8 PIK36749.1 - 0.046 13.6 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 Transcriptional activator TraM Cerato-platanin PF07249.12 PIK36749.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Cerato-platanin GH3 PF03321.13 PIK36750.1 - 8.5e-83 279.0 0.7 4.5e-64 217.2 0.0 2.0 1 1 1 2 2 2 2 GH3 auxin-responsive promoter RVT_1 PF00078.27 PIK36751.1 - 8.4e-06 25.5 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2481 PF10654.9 PIK36751.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) YebG PF07130.12 PIK36751.1 - 0.15 11.9 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 YebG protein NACHT PF05729.12 PIK36752.1 - 9.9e-18 64.6 0.0 1.9e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK36752.1 - 1e-07 32.4 0.9 0.2 12.3 0.0 4.6 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK36752.1 - 1.1e-06 28.8 3.4 0.022 14.9 0.0 4.1 5 0 0 5 5 5 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK36752.1 - 0.00015 22.0 4.2 2.2 8.7 0.0 4.7 4 1 1 5 5 5 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK36752.1 - 0.00053 20.0 2.6 0.27 11.3 0.3 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain NB-ARC PF00931.22 PIK36752.1 - 0.0026 17.0 0.0 0.0052 16.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK36752.1 - 0.0033 17.7 0.0 0.0093 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK36752.1 - 0.02 14.5 0.0 0.3 10.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain I-set PF07679.16 PIK36752.1 - 0.023 14.7 0.4 0.51 10.4 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin I-set domain DUF2075 PF09848.9 PIK36752.1 - 0.029 13.6 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) EphA2_TM PF14575.6 PIK36752.1 - 0.15 13.0 0.2 2.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ZU5 PF00791.20 PIK36753.1 - 8.7e-13 48.4 0.1 5.6e-12 45.9 0.1 2.5 2 0 0 2 2 2 1 ZU5 domain GAS PF13851.6 PIK36753.1 - 3.1e-07 29.9 18.8 3.1e-07 29.9 18.8 3.5 3 2 1 4 4 4 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 PIK36753.1 - 0.0013 18.8 17.1 0.0013 18.8 17.1 6.3 2 1 4 6 6 6 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tox-HDC PF15656.6 PIK36753.1 - 0.1 12.8 1.4 2.4 8.4 0.0 3.6 2 1 0 2 2 2 0 Toxin with a H, D/N and C signature DivIC PF04977.15 PIK36753.1 - 4 7.3 52.6 0.07 12.9 4.1 7.2 3 2 2 6 6 6 0 Septum formation initiator PI-PLC-Y PF00387.19 PIK36753.1 - 4.1 7.8 8.2 0.12 12.7 0.3 2.5 3 0 0 3 3 3 0 Phosphatidylinositol-specific phospholipase C, Y domain WSC PF01822.19 PIK36754.1 - 2.7e-08 33.9 8.0 7.8e-08 32.4 8.0 1.8 1 0 0 1 1 1 1 WSC domain CUB PF00431.20 PIK36754.1 - 1.1e-07 32.2 0.0 2.7e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 PIK36754.1 - 3.7e-06 27.4 8.5 0.002 18.7 0.1 2.8 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) TIL PF01826.17 PIK36755.1 - 3.7e-07 30.3 17.0 3.7e-07 30.3 17.0 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK36755.1 - 7.3e-05 22.9 9.1 7.3e-05 22.9 9.1 3.8 3 1 0 3 3 3 1 EGF domain EGF PF00008.27 PIK36755.1 - 0.0086 16.4 4.1 0.0086 16.4 4.1 3.7 4 0 0 4 4 4 2 EGF-like domain Glyco_hydro_3 PF00933.21 PIK36756.1 - 8.7e-48 163.3 0.0 3.4e-47 161.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 PIK36756.1 - 2.8e-34 118.9 0.0 5.3e-33 114.7 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 PIK36756.1 - 1.9e-14 53.5 0.4 4.3e-14 52.4 0.3 1.7 2 0 0 2 2 2 1 Fibronectin type III-like domain ADH_N PF08240.12 PIK36757.1 - 2.2e-30 104.7 1.1 4e-30 103.9 1.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK36757.1 - 7e-16 58.4 0.0 1.1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK36757.1 - 1.5e-09 37.6 0.1 2.7e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK36757.1 - 0.003 16.9 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 PIK36758.1 - 8.7e-30 102.8 1.2 1.7e-29 101.8 1.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK36758.1 - 2e-18 66.6 0.0 3e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK36758.1 - 6.1e-11 42.2 0.1 1.5e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK36758.1 - 0.00018 20.9 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 PIK36758.1 - 0.056 13.0 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_16 PF10294.9 PIK36758.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase 2-Hacid_dh_C PF02826.19 PIK36758.1 - 0.14 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DEAD PF00270.29 PIK36759.1 - 2.2e-32 112.3 0.2 3.8e-32 111.5 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK36759.1 - 7.3e-29 100.3 0.0 1.6e-26 92.8 0.0 3.0 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 PIK36759.1 - 0.013 14.7 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 PIK36759.1 - 0.028 13.8 0.0 0.061 12.7 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 PIK36759.1 - 0.094 13.0 0.1 0.19 12.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 PIK36759.1 - 0.13 12.2 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.25 PIK36760.1 - 8.7e-53 179.1 0.7 1.4e-34 119.6 0.2 2.3 1 1 1 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 PIK36760.1 - 5e-47 159.3 1.3 7.7e-47 158.8 1.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 PIK36760.1 - 3.1e-09 37.2 0.7 3.8e-08 33.7 0.7 2.8 1 1 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.6 PIK36760.1 - 6.8e-05 23.1 0.8 0.00013 22.3 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) ARF7EP_C PF14949.6 PIK36761.1 - 1.6e-27 96.2 8.3 1.6e-27 96.2 8.3 3.0 2 1 2 4 4 4 1 ARF7 effector protein C-terminus THAP PF05485.12 PIK36761.1 - 3.4e-10 40.7 2.9 1.3e-09 38.8 1.4 2.7 2 0 0 2 2 2 1 THAP domain zf-CHY PF05495.12 PIK36762.1 - 2.3e-14 53.6 8.3 3.7e-14 52.9 8.3 1.4 1 1 0 1 1 1 1 CHY zinc finger zf_CCCH_4 PF18345.1 PIK36763.1 - 2.6e-06 27.3 7.1 5.8e-06 26.2 7.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 PIK36763.1 - 1.3e-05 24.9 4.5 2.3e-05 24.1 4.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RWD PF05773.22 PIK36763.1 - 0.00029 21.1 0.7 0.00059 20.1 0.0 2.0 2 0 0 2 2 2 1 RWD domain Torus PF16131.5 PIK36763.1 - 0.00042 21.0 0.0 0.0011 19.6 0.0 1.7 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 PIK36763.1 - 0.00048 19.9 3.4 0.001 18.8 3.4 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 PIK36763.1 - 0.00056 20.3 3.2 0.001 19.5 3.2 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 PIK36763.1 - 0.013 15.7 0.4 0.041 14.1 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger containing family UQ_con PF00179.26 PIK36763.1 - 0.039 13.6 0.1 0.092 12.4 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme HypA PF01155.19 PIK36763.1 - 0.061 13.3 0.3 0.12 12.4 0.3 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA E7 PF00527.18 PIK36763.1 - 0.51 10.6 3.1 0.51 10.6 0.6 2.4 2 0 0 2 2 2 0 E7 protein, Early protein Linker_histone PF00538.19 PIK36764.1 - 1.1e-20 73.7 0.8 1.1e-20 73.7 0.8 2.8 2 1 0 2 2 2 1 linker histone H1 and H5 family SLC12 PF03522.15 PIK36764.1 - 3.3 6.6 14.4 3.8 6.4 14.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4551 PF15087.6 PIK36764.1 - 9.7 4.9 13.2 9.4 4.9 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Adaptin_binding PF10199.9 PIK36765.1 - 7e-16 58.9 2.9 7e-16 58.9 2.9 1.8 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 LRR_4 PF12799.7 PIK36766.1 - 8.1e-09 35.6 3.7 1.7e-07 31.4 0.3 2.4 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK36766.1 - 0.00042 20.0 3.4 0.0046 16.7 0.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 PIK36766.1 - 0.021 14.3 0.3 0.03 13.8 0.3 1.4 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 PIK36766.1 - 0.1 13.2 1.0 27 5.8 0.0 3.5 2 2 0 2 2 2 0 Leucine Rich Repeat rve PF00665.26 PIK36767.1 - 5.9e-23 81.3 0.0 8.9e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36767.1 - 1.7e-05 24.8 0.0 4.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK36767.1 - 0.0056 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK36768.1 - 1.1e-10 41.5 0.0 1.2e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK36770.1 - 7.9e-29 100.8 0.0 1.2e-28 100.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK36770.1 - 4.7e-20 71.9 0.0 9e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36770.1 - 8.7e-11 41.8 0.0 2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK36770.1 - 2.6e-05 23.9 0.0 6.7e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK36770.1 - 0.11 12.8 0.0 0.51 10.6 0.0 2.2 2 0 0 2 2 2 0 H2C2 zinc finger SCAN PF02023.17 PIK36771.1 - 7.1e-11 41.8 0.2 1.1e-10 41.2 0.2 1.3 1 0 0 1 1 1 1 SCAN domain Pkinase_Tyr PF07714.17 PIK36772.1 - 6.9e-20 71.4 0.0 1.3e-19 70.5 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36772.1 - 3.4e-16 59.4 0.0 8e-16 58.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Ceramidase_alk PF04734.13 PIK36772.1 - 0.31 9.6 3.0 0.38 9.3 3.0 1.1 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, N-terminal DUF4795 PF16043.5 PIK36773.1 - 0.014 15.0 2.5 0.019 14.6 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Pkip-1 PF06878.11 PIK36773.1 - 0.057 13.5 1.9 0.42 10.7 0.2 2.0 2 0 0 2 2 2 0 Pkip-1 protein Cep57_CLD PF14073.6 PIK36773.1 - 0.064 13.3 3.2 0.082 12.9 3.2 1.1 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 DASH_Hsk3 PF08227.11 PIK36773.1 - 0.096 13.1 2.9 0.096 13.1 2.9 2.2 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like DUF724 PF05266.14 PIK36773.1 - 0.14 12.0 0.4 0.17 11.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 PIK36773.1 - 0.15 12.3 3.3 0.2 11.9 3.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF2730 PF10805.8 PIK36773.1 - 0.31 11.2 1.9 1.7 8.8 1.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4763 PF15960.5 PIK36773.1 - 0.38 10.0 8.6 0.52 9.6 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) SlyX PF04102.12 PIK36773.1 - 0.43 11.2 4.1 3.1 8.5 0.3 2.2 1 1 1 2 2 2 0 SlyX CCDC53 PF10152.9 PIK36773.1 - 0.73 10.2 4.0 11 6.5 4.1 2.0 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex Peptidase_S8 PF00082.22 PIK36774.1 - 1.4e-37 129.6 0.1 2.2e-37 129.0 0.1 1.3 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.9 PIK36774.1 - 0.0023 17.4 0.0 0.0051 16.3 0.0 1.5 1 0 0 1 1 1 1 ABC-type uncharacterized transport system Aldedh PF00171.22 PIK36776.1 - 2.5e-97 326.3 0.0 3.4e-97 325.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Spermine_synth PF01564.17 PIK36777.1 - 2.7e-56 190.0 0.0 3.2e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 PIK36777.1 - 3.8e-05 24.3 0.0 7.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK36777.1 - 0.0013 19.5 0.0 0.0018 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK36777.1 - 0.004 17.0 0.0 0.0052 16.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 PIK36777.1 - 0.033 13.3 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase MTS PF05175.14 PIK36777.1 - 0.075 12.6 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 PIK36777.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Acyl_transf_3 PF01757.22 PIK36778.1 - 5.7e-12 45.3 45.8 1.4e-11 44.1 45.8 1.6 1 1 0 1 1 1 1 Acyltransferase family Ycf1 PF05758.12 PIK36779.1 - 0.11 10.3 0.0 0.16 9.8 0.0 1.2 1 0 0 1 1 1 0 Ycf1 Enolase_C PF00113.22 PIK36780.1 - 2.9e-149 496.2 0.1 3.8e-149 495.8 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 PIK36780.1 - 1.6e-57 193.3 0.2 2.9e-57 192.5 0.2 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 PIK36780.1 - 3.4e-05 23.5 0.0 4.9e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 PIK36780.1 - 0.00013 21.2 0.4 0.00029 20.1 0.4 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Ribosomal_L22e PF01776.17 PIK36781.1 - 3e-33 114.4 5.1 8.5e-27 93.7 3.5 2.2 2 0 0 2 2 2 2 Ribosomal L22e protein family G_path_suppress PF15991.5 PIK36782.1 - 1.5e-34 120.4 18.7 2.3e-34 119.8 18.7 1.3 1 0 0 1 1 1 1 G-protein pathway suppressor DivIC PF04977.15 PIK36782.1 - 6.1 6.7 7.9 0.8 9.5 1.8 2.3 1 1 1 2 2 2 0 Septum formation initiator IFT57 PF10498.9 PIK36783.1 - 4.8e-05 22.5 12.9 7e-05 22.0 12.9 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Lebercilin PF15619.6 PIK36783.1 - 0.0012 18.6 15.2 0.0027 17.4 15.2 1.6 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.8 PIK36783.1 - 0.0042 17.0 17.5 0.007 16.3 8.0 2.5 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 PIK36783.1 - 0.015 15.4 5.9 0.023 14.8 5.9 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 PIK36783.1 - 0.035 13.5 3.9 0.044 13.1 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HemX PF04375.14 PIK36783.1 - 0.043 13.1 11.5 0.075 12.3 11.5 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF812 PF05667.11 PIK36783.1 - 0.062 12.2 12.0 0.093 11.6 12.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) NPV_P10 PF05531.12 PIK36783.1 - 0.074 13.5 8.3 0.22 12.0 3.4 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 PIK36783.1 - 0.083 12.0 14.0 0.014 14.5 10.3 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.11 PIK36783.1 - 0.094 12.5 11.0 0.18 11.6 11.0 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 SKA1 PF07160.12 PIK36783.1 - 0.14 12.0 11.1 0.23 11.3 11.1 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF724 PF05266.14 PIK36783.1 - 0.16 11.8 13.7 0.47 10.3 12.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) MAD PF05557.13 PIK36783.1 - 0.27 9.6 15.5 0.41 8.9 15.5 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein Tektin PF03148.14 PIK36783.1 - 0.33 9.7 14.5 8.3 5.0 12.5 2.3 2 0 0 2 2 2 0 Tektin family DUF1043 PF06295.12 PIK36783.1 - 0.39 10.7 11.5 0.8 9.7 11.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) FlaC_arch PF05377.11 PIK36783.1 - 0.47 10.9 8.5 6.5 7.2 4.4 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) OEP PF02321.18 PIK36783.1 - 0.47 10.2 14.0 0.84 9.4 14.0 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein HR1 PF02185.16 PIK36783.1 - 0.5 10.5 19.3 16 5.7 7.8 2.7 1 1 1 2 2 2 0 Hr1 repeat DUF3552 PF12072.8 PIK36783.1 - 0.57 9.6 14.8 1 8.7 14.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) SlyX PF04102.12 PIK36783.1 - 0.75 10.5 21.4 0.054 14.1 8.9 3.0 2 1 1 3 3 2 0 SlyX FapA PF03961.13 PIK36783.1 - 0.8 8.2 9.9 1.1 7.8 9.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 PIK36783.1 - 0.92 9.8 13.7 2e+02 2.3 13.7 2.6 1 1 0 1 1 1 0 ABC transporter C-terminal domain DASH_Dad1 PF08649.10 PIK36783.1 - 1.1 9.5 5.2 15 5.8 0.4 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad1 V_ATPase_I PF01496.19 PIK36783.1 - 1.3 6.8 7.7 1.7 6.5 7.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 PIK36783.1 - 1.6 8.8 11.3 1.6 8.8 2.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 PIK36783.1 - 1.7 7.5 2.8 2 7.3 2.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Prominin PF05478.11 PIK36783.1 - 2.3 6.0 9.8 3 5.7 9.8 1.1 1 0 0 1 1 1 0 Prominin CCDC-167 PF15188.6 PIK36783.1 - 3.1 8.2 10.8 2.5 8.5 8.8 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Fib_alpha PF08702.10 PIK36783.1 - 4 7.6 11.9 10 6.3 11.9 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-CpG_bind_C PF12269.8 PIK36783.1 - 4.8 6.9 9.1 2.6 7.8 6.7 1.7 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain TMPIT PF07851.13 PIK36783.1 - 5.2 6.2 10.3 7.6 5.7 10.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF948 PF06103.11 PIK36783.1 - 7.1 7.0 7.4 30 5.0 6.5 2.4 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 PIK36783.1 - 7.5 6.1 13.2 3.2 7.3 1.6 2.2 1 1 1 2 2 2 0 fzo-like conserved region HECT PF00632.25 PIK36784.1 - 0.00018 21.1 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF1699 PF08004.11 PIK36784.1 - 0.041 13.6 0.0 0.095 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) rve PF00665.26 PIK36785.1 - 0.003 17.7 0.0 0.0088 16.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 PIK36785.1 - 0.0057 16.8 0.2 0.015 15.4 0.2 1.7 1 0 0 1 1 1 1 HTH-like domain ADH_zinc_N PF00107.26 PIK36788.1 - 3.5e-22 78.8 0.1 5.3e-22 78.2 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK36788.1 - 2.8e-12 47.8 0.0 5.2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 PIK36788.1 - 1.2e-10 41.3 0.2 2.4e-10 40.3 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase SH2 PF00017.24 PIK36789.1 - 4.9e-14 52.2 0.1 8.5e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 SH2 domain TMEM154 PF15102.6 PIK36790.1 - 0.00038 20.4 0.2 0.001 19.0 0.1 1.8 2 0 0 2 2 2 1 TMEM154 protein family Insulin_TMD PF17870.1 PIK36790.1 - 0.0059 16.6 2.1 0.012 15.6 2.1 1.5 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment DAG1 PF05454.11 PIK36790.1 - 0.01 15.2 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) CD34_antigen PF06365.12 PIK36790.1 - 0.029 13.9 0.1 0.045 13.3 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Orf78 PF06024.12 PIK36790.1 - 0.043 14.1 0.1 0.075 13.3 0.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) SIT PF15330.6 PIK36790.1 - 0.077 13.4 0.1 0.24 11.9 0.0 1.8 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF5305 PF17231.2 PIK36790.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Adeno_E3_CR2 PF02439.15 PIK36790.1 - 0.11 12.3 4.3 0.22 11.3 4.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Tweety PF04906.13 PIK36790.1 - 0.15 10.7 0.2 0.21 10.2 0.2 1.1 1 0 0 1 1 1 0 Tweety Shisa PF13908.6 PIK36790.1 - 0.19 12.0 0.0 0.28 11.4 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Syndecan PF01034.20 PIK36790.1 - 0.23 11.4 1.3 0.4 10.6 1.3 1.3 1 0 0 1 1 1 0 Syndecan domain Lectin_C PF00059.21 PIK36791.1 - 1.5e-19 70.7 0.2 2.2e-19 70.2 0.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain F5_F8_type_C PF00754.25 PIK36791.1 - 8.1e-10 38.9 0.0 1.5e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Tudor-knot PF11717.8 PIK36792.1 - 0.015 15.2 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Rib PF08428.10 PIK36792.1 - 0.065 13.2 0.0 19 5.3 0.0 2.5 3 0 0 3 3 3 0 Rib/alpha-like repeat zf-RING-like PF08746.11 PIK36792.1 - 0.14 12.5 0.4 0.29 11.5 0.4 1.5 1 0 0 1 1 1 0 RING-like domain Inhibitor_I9 PF05922.16 PIK36793.1 - 0.0049 17.5 0.0 0.0076 16.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 I-set PF07679.16 PIK36794.1 - 0.018 15.1 0.1 2.1 8.5 0.0 3.3 4 0 0 4 4 4 0 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK36794.1 - 0.027 14.5 1.4 0.28 11.3 0.0 2.8 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK36794.1 - 1.1 9.9 4.5 1.5e+02 3.1 0.0 4.6 4 2 2 6 6 6 0 Immunoglobulin domain Cnd1 PF12717.7 PIK36796.1 - 5.2e-28 98.1 0.3 5.2e-28 98.1 0.3 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK36796.1 - 0.15 12.5 0.0 0.8 10.1 0.0 2.3 3 0 0 3 3 3 0 HEAT repeats HEAT PF02985.22 PIK36796.1 - 0.47 10.8 2.0 3.2 8.3 0.1 3.3 3 0 0 3 3 3 0 HEAT repeat DUF3347 PF11827.8 PIK36796.1 - 1.3 9.2 4.5 2.1 8.5 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Cnd1 PF12717.7 PIK36797.1 - 0.00011 22.3 1.7 0.0012 18.9 1.7 2.2 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 PIK36797.1 - 0.00014 22.1 0.1 0.22 11.9 0.0 2.7 2 0 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 PIK36797.1 - 0.0062 16.7 0.4 3.5 8.1 0.1 2.9 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 PIK36797.1 - 0.013 15.9 0.1 0.055 13.9 0.0 2.0 2 0 0 2 2 2 0 HEAT repeats TIP49_C PF17856.1 PIK36797.1 - 0.037 14.1 0.2 2.2 8.5 0.0 2.4 2 0 0 2 2 2 0 TIP49 AAA-lid domain STAG PF08514.11 PIK36798.1 - 0.067 13.1 0.9 0.38 10.7 0.3 2.4 2 0 0 2 2 2 0 STAG domain RhoGAP PF00620.27 PIK36799.1 - 1.6e-38 131.9 0.1 5.2e-38 130.3 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain Thioredoxin_11 PF18078.1 PIK36799.1 - 0.061 13.5 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 Thioredoxin-like SNTX domain ArAE_2 PF10334.9 PIK36800.1 - 0.0075 16.1 0.1 0.011 15.6 0.1 1.2 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 DUF1351 PF07083.11 PIK36800.1 - 0.055 13.2 9.1 0.11 12.3 9.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Rsd_AlgQ PF04353.13 PIK36800.1 - 0.45 10.5 5.9 0.63 10.0 3.1 2.1 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF4208 PF13907.6 PIK36800.1 - 0.73 10.3 5.8 0.19 12.2 2.0 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) TMPIT PF07851.13 PIK36800.1 - 0.96 8.6 7.4 1.5 8.0 7.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein zf-RING_UBOX PF13445.6 PIK36801.1 - 4.5e-10 39.4 6.2 4.5e-10 39.4 6.2 3.2 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK36801.1 - 2.5e-09 36.9 9.1 2.5e-09 36.9 9.1 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK36801.1 - 1.2e-06 28.3 9.3 1.2e-06 28.3 9.3 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK36801.1 - 1.4e-06 28.0 28.7 2.8e-06 27.1 10.3 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK36801.1 - 4e-06 27.1 7.6 4e-06 27.1 7.6 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK36801.1 - 7.7e-06 26.0 9.3 7.7e-06 26.0 9.3 3.0 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK36801.1 - 2.4e-05 24.2 7.6 2.4e-05 24.2 7.6 2.8 3 0 0 3 3 3 2 zinc-RING finger domain zf-B_box PF00643.24 PIK36801.1 - 0.0022 18.1 7.3 0.0022 18.1 7.3 4.5 5 1 0 5 5 5 1 B-box zinc finger Prok-RING_4 PF14447.6 PIK36801.1 - 0.014 15.2 10.9 0.014 15.2 10.9 2.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK36801.1 - 0.086 12.6 0.4 0.086 12.6 0.4 3.1 2 0 0 2 2 2 0 RING-like zinc finger Siva PF05458.12 PIK36801.1 - 0.66 9.6 12.9 0.15 11.8 1.7 2.3 2 0 0 2 2 2 0 Cd27 binding protein (Siva) CEBP_ZZ PF16366.5 PIK36801.1 - 4.1 7.7 25.4 0.25 11.6 6.9 3.5 3 1 0 3 3 3 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-UDP PF14569.6 PIK36801.1 - 5.3 7.2 19.7 1 9.5 5.1 2.9 2 2 0 2 2 2 0 Zinc-binding RING-finger zf-B_box PF00643.24 PIK36802.1 - 1.3e-05 25.2 32.5 0.00041 20.4 4.9 3.4 3 0 0 3 3 3 2 B-box zinc finger Bap31_Bap29_C PF18035.1 PIK36802.1 - 0.00035 20.5 4.3 0.00097 19.1 4.3 1.7 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Zein-binding PF04576.15 PIK36802.1 - 0.018 15.3 1.3 0.018 15.3 1.3 2.4 2 1 0 2 2 2 0 Zein-binding Baculo_PEP_C PF04513.12 PIK36802.1 - 0.12 12.5 9.3 0.38 10.8 2.6 3.2 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NHL PF01436.21 PIK36802.1 - 0.27 11.4 3.0 43 4.4 0.0 4.1 4 0 0 4 4 4 0 NHL repeat Siva PF05458.12 PIK36802.1 - 0.66 9.6 10.0 1 9.0 0.8 2.8 2 0 0 2 2 2 0 Cd27 binding protein (Siva) TolA_bind_tri PF16331.5 PIK36802.1 - 3.2 7.9 10.8 0.12 12.4 1.4 2.8 1 1 1 2 2 2 0 TolA binding protein trimerisation Mei5_like PF17021.5 PIK36802.1 - 4.7 7.3 11.8 1.5 8.8 2.7 2.5 1 1 1 2 2 2 0 Putative double-strand recombination repair-like Phasin PF05597.11 PIK36802.1 - 7.3 6.6 10.4 1.4 8.9 4.1 2.6 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) 7tm_1 PF00001.21 PIK36803.1 - 7.1e-45 153.4 16.8 9.6e-45 153.0 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK36803.1 - 3.8e-10 39.6 18.6 4.9e-10 39.2 18.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK36803.1 - 1.8e-09 37.7 24.9 2e-09 37.5 22.1 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK36803.1 - 0.0058 16.4 12.3 0.047 13.4 12.3 2.1 1 1 0 1 1 1 1 Olfactory receptor EMP70 PF02990.16 PIK36804.1 - 2.3e-08 33.2 0.0 2.9e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EMP70 PF02990.16 PIK36805.1 - 3.9e-146 487.8 27.4 1.4e-134 449.7 27.6 2.5 2 1 1 3 3 3 2 Endomembrane protein 70 Exo_endo_phos_2 PF14529.6 PIK36806.1 - 1.8e-09 37.5 0.1 1.8e-09 37.5 0.1 2.2 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Ribosomal_L6e_N PF03868.15 PIK36806.1 - 0.0051 17.0 0.2 0.011 15.9 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L6, N-terminal domain Exo_endo_phos PF03372.23 PIK36806.1 - 0.012 15.1 0.6 0.028 14.0 0.6 1.6 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ig_2 PF13895.6 PIK36808.1 - 0.012 15.9 2.4 1.2 9.6 1.0 2.5 2 1 0 2 2 2 0 Immunoglobulin domain DUF3821 PF12863.7 PIK36808.1 - 0.052 13.4 0.6 0.13 12.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3821) Ig_6 PF18452.1 PIK36808.1 - 0.084 12.5 0.1 0.58 9.8 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain zf-CCHC PF00098.23 PIK36810.1 - 0.016 15.2 0.2 0.029 14.4 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle Cas_Cmr5 PF09701.10 PIK36811.1 - 0.14 12.4 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cmr5) Mis12 PF05859.12 PIK36812.1 - 1.3e-16 60.9 3.9 4.4e-16 59.2 0.3 2.9 2 1 0 2 2 2 1 Mis12 protein Septin PF00735.18 PIK36812.1 - 2e-11 43.7 0.2 6.3e-11 42.1 0.2 1.8 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 PIK36812.1 - 6.6e-10 39.1 0.5 6.6e-10 39.1 0.5 1.9 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 PIK36812.1 - 5e-07 29.8 0.1 2.1e-06 27.8 0.1 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK36812.1 - 3.5e-05 23.9 0.6 0.4 10.7 0.1 3.0 1 1 1 2 2 2 2 Dynamin family AAA_19 PF13245.6 PIK36812.1 - 0.00031 21.1 0.1 0.0033 17.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 PIK36812.1 - 0.0013 17.9 0.1 0.0035 16.5 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 PIK36812.1 - 0.0019 18.3 0.0 0.0061 16.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK36812.1 - 0.002 18.1 0.4 0.03 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK36812.1 - 0.0021 18.3 0.1 0.042 14.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 PIK36812.1 - 0.003 17.3 0.1 0.13 12.0 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 PIK36812.1 - 0.0049 17.4 0.1 0.022 15.3 0.0 2.2 2 0 0 2 2 1 1 ABC transporter AAA_28 PF13521.6 PIK36812.1 - 0.0049 17.1 1.2 0.039 14.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain IFT20 PF14931.6 PIK36812.1 - 0.005 17.0 2.1 0.008 16.3 0.2 2.3 2 0 0 2 2 1 1 Intraflagellar transport complex B, subunit 20 GTP_EFTU PF00009.27 PIK36812.1 - 0.0065 16.0 0.4 0.016 14.8 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 PIK36812.1 - 0.0068 16.4 0.8 0.026 14.4 0.0 2.4 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 PIK36812.1 - 0.0077 16.0 0.1 0.27 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 PIK36812.1 - 0.015 14.6 1.7 0.02 14.2 0.2 2.0 2 1 0 2 2 1 0 AIG1 family SRP54 PF00448.22 PIK36812.1 - 0.017 14.8 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 PIK36812.1 - 0.017 14.4 0.0 0.053 12.8 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 PIK36812.1 - 0.017 15.1 0.1 0.047 13.7 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 PIK36812.1 - 0.022 15.3 0.1 0.2 12.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK36812.1 - 0.025 15.0 0.0 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 PIK36812.1 - 0.028 14.1 0.5 0.071 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 PIK36812.1 - 0.029 14.0 0.3 0.089 12.4 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 PIK36812.1 - 0.036 13.6 0.2 6.3 6.3 0.2 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_25 PF13481.6 PIK36812.1 - 0.046 13.3 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK36812.1 - 0.048 13.2 0.1 0.12 11.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 PIK36812.1 - 0.062 13.0 0.1 0.17 11.6 0.0 1.8 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 PIK36812.1 - 0.068 13.6 0.1 0.37 11.2 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 PIK36812.1 - 0.073 13.6 9.6 0.044 14.3 2.7 3.0 2 1 1 3 3 2 0 AAA domain Roc PF08477.13 PIK36812.1 - 0.088 13.0 0.0 0.32 11.2 0.0 2.1 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 PIK36812.1 - 0.11 11.8 0.3 0.21 10.9 0.3 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 PIK36812.1 - 0.12 12.2 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 PIK36812.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.9 PIK36812.1 - 0.36 9.7 2.2 0.54 9.1 0.6 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Peptidase_S28 PF05577.12 PIK36813.1 - 1.7e-145 485.1 4.9 2e-145 484.9 4.9 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 PIK36813.1 - 4.3e-06 26.6 0.1 6.7e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold UPF0147 PF03685.13 PIK36813.1 - 0.072 13.1 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) DUF4154 PF13689.6 PIK36817.1 - 0.088 13.0 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 YfiR/HmsC-like PC4 PF02229.16 PIK36818.1 - 3.1e-17 61.9 0.4 5.4e-17 61.2 0.4 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) DUF445 PF04286.12 PIK36818.1 - 0.015 15.2 0.0 0.028 14.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) DUF2497 PF10691.9 PIK36818.1 - 0.019 15.4 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) RVT_1 PF00078.27 PIK36819.1 - 1.3e-07 31.3 0.0 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MAM33 PF02330.16 PIK36819.1 - 0.011 15.7 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial glycoprotein zf-CCHC PF00098.23 PIK36820.1 - 3.2e-07 30.1 15.8 0.00055 19.9 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK36820.1 - 0.00049 19.9 8.1 0.084 12.7 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK36820.1 - 0.016 15.2 15.6 0.27 11.2 0.1 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36820.1 - 0.018 14.8 0.2 0.018 14.8 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK36820.1 - 0.019 14.7 0.8 0.019 14.7 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK36820.1 - 0.02 14.6 11.1 4.1 7.2 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle RseA_C PF03873.13 PIK36820.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain zf-CCHC PF00098.23 PIK36821.1 - 1.5e-06 28.0 16.2 0.00083 19.3 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK36821.1 - 0.0012 18.6 8.2 0.13 12.1 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK36821.1 - 0.0094 15.9 12.8 0.29 11.1 1.2 3.5 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36821.1 - 0.028 14.3 0.2 0.028 14.3 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK36821.1 - 0.028 14.1 0.8 0.028 14.1 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK36821.1 - 0.067 12.9 11.1 6.2 6.6 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC PF00098.23 PIK36822.1 - 1.9e-05 24.5 16.1 0.0031 17.5 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK36822.1 - 5.7e-05 22.8 6.2 0.0028 17.4 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK36822.1 - 0.00017 21.2 14.2 0.47 10.2 1.1 3.7 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK36822.1 - 1.4 9.2 12.4 0.54 10.5 6.9 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK36822.1 - 4.8 7.0 12.9 0.86 9.4 0.3 4.0 4 0 0 4 4 4 0 C2H2 zinc-finger DUF4371 PF14291.6 PIK36823.1 - 2.3e-31 109.2 0.2 3.3e-31 108.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK36823.1 - 0.024 14.5 0.1 0.064 13.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 PIK36824.1 - 8e-15 54.4 0.6 1.6e-14 53.4 0.2 1.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF4218 PF13960.6 PIK36826.1 - 0.00021 20.9 0.0 0.00042 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Fibrinogen_C PF00147.18 PIK36827.1 - 1.4e-70 237.6 8.6 7.7e-44 150.1 2.3 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK36827.1 - 2.7e-07 30.4 2.4 2.7e-07 30.4 2.4 2.3 2 0 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK36827.1 - 0.00066 19.8 13.4 0.00066 19.8 13.4 2.9 2 1 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK36827.1 - 0.0014 18.7 6.2 0.0049 16.9 6.2 2.0 1 0 0 1 1 1 1 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK36827.1 - 7.9 7.0 18.9 0.11 12.9 9.8 2.6 2 0 0 2 2 2 0 EGF-like domain Fibrinogen_C PF00147.18 PIK36828.1 - 2.1e-45 155.2 3.2 2.4e-45 155.0 3.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK36828.1 - 0.046 13.0 0.3 0.053 12.8 0.3 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain BAF PF02961.14 PIK36829.1 - 5.6e-35 119.7 0.1 6.2e-35 119.5 0.1 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor CNH PF00780.22 PIK36830.1 - 7.3e-28 97.9 0.0 1.3e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 PIK36830.1 - 1e-21 77.2 14.8 1.5e-21 76.7 6.4 4.3 4 1 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 PIK36830.1 - 9.7e-11 41.7 6.9 1.6e-06 28.1 0.0 4.0 4 1 0 4 4 4 2 Region in Clathrin and VPS Vps39_2 PF10367.9 PIK36830.1 - 2.8e-05 24.5 0.1 0.00035 21.0 0.0 2.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CH PF00307.31 PIK36831.1 - 9.2e-32 109.5 0.3 1.5e-20 73.4 0.2 2.0 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK36831.1 - 3.1e-06 26.9 0.2 1.4e-05 24.8 0.0 2.1 3 0 0 3 3 3 1 CAMSAP CH domain Spectrin PF00435.21 PIK36832.1 - 9.3e-77 254.3 37.8 1.4e-23 83.4 2.6 6.3 6 0 0 6 6 6 5 Spectrin repeat Myb_DNA-bind_4 PF13837.6 PIK36832.1 - 1.1e-08 35.3 0.9 2e-05 24.9 0.1 4.0 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain GLTSCR1 PF15249.6 PIK36832.1 - 0.24 11.8 9.3 22 5.6 0.0 4.6 3 1 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein Occludin_ELL PF07303.13 PIK36832.1 - 0.98 10.2 8.1 1.6 9.5 1.0 4.0 4 0 0 4 4 4 0 Occludin homology domain BLOC1_2 PF10046.9 PIK36832.1 - 1.7 9.0 11.8 0.19 12.1 1.1 3.7 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YtxH PF12732.7 PIK36832.1 - 1.7 9.2 4.8 31 5.2 0.5 3.8 3 0 0 3 3 3 0 YtxH-like protein TMF_TATA_bd PF12325.8 PIK36832.1 - 9.2 6.5 18.0 0.93 9.7 2.8 4.5 3 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding Serinc PF03348.15 PIK36833.1 - 1.6e-14 53.7 12.5 1.8e-14 53.5 12.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) 5TM-5TMR_LYT PF07694.12 PIK36833.1 - 0.066 12.7 1.9 0.081 12.4 1.9 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Imm17 PF15562.6 PIK36833.1 - 0.084 12.8 0.7 0.17 11.8 0.7 1.5 1 0 0 1 1 1 0 Immunity protein 17 MatE PF01554.18 PIK36834.1 - 0.00053 19.7 4.5 0.00053 19.7 4.5 2.3 2 1 0 2 2 2 1 MatE Pkinase PF00069.25 PIK36835.1 - 1.2e-32 113.4 0.0 1.6e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36835.1 - 3.5e-18 65.8 0.0 4.2e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK36835.1 - 9.1e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK36835.1 - 0.01 15.5 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 PIK36835.1 - 0.025 14.5 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK36835.1 - 0.043 12.8 0.0 0.06 12.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 PIK36835.1 - 0.082 12.2 0.0 0.61 9.3 0.0 1.9 1 1 0 1 1 1 0 Kinase-like LRAT PF04970.13 PIK36836.1 - 1.1e-16 61.2 1.4 1.1e-10 41.9 0.1 3.0 2 1 0 2 2 2 2 Lecithin retinol acyltransferase Gly-zipper_YMGG PF13441.6 PIK36836.1 - 0.0032 17.2 10.9 0.0032 17.2 10.9 1.8 1 1 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 PIK36836.1 - 0.0048 16.7 16.7 0.013 15.3 16.7 1.8 1 0 0 1 1 1 1 Glycine-zipper domain Peptidase_C97 PF05903.14 PIK36836.1 - 0.025 14.4 1.2 6.3 6.6 0.1 2.4 2 0 0 2 2 2 0 PPPDE putative peptidase domain Gly-zipper_Omp PF13488.6 PIK36836.1 - 9.9 6.3 22.4 2.9 8.0 17.3 2.5 1 1 2 3 3 3 0 Glycine zipper Kinesin PF00225.23 PIK36837.1 - 6e-95 318.0 4.3 6e-95 318.0 4.3 5.2 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 PIK36837.1 - 8.9e-14 51.7 0.3 8.9e-14 51.7 0.3 5.8 4 3 2 6 6 6 2 Microtubule binding DUF572 PF04502.13 PIK36838.1 - 0.23 11.0 22.6 0.28 10.8 22.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) RVT_1 PF00078.27 PIK36839.1 - 3.1e-30 105.3 0.0 4.4e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK36840.1 - 1.4e-22 80.1 0.0 2.8e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36840.1 - 8.1e-19 67.5 0.3 1.6e-18 66.5 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK36840.1 - 4.3e-09 36.6 0.1 1e-08 35.4 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK36840.1 - 3.1e-07 30.1 0.6 9.5e-07 28.5 0.6 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK36840.1 - 0.0019 18.4 0.2 0.0057 16.8 0.2 1.8 1 0 0 1 1 1 1 H2C2 zinc finger DUF2577 PF10844.8 PIK36840.1 - 0.083 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) WD40 PF00400.32 PIK36841.1 - 1.5e-27 95.2 20.1 4.7e-06 27.2 0.2 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK36841.1 - 4e-06 27.0 1.1 0.3 11.4 0.1 3.7 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK36841.1 - 5.6e-06 25.3 6.8 0.065 11.9 0.1 3.2 1 1 0 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK36841.1 - 0.00012 22.1 0.0 0.061 13.2 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 PIK36841.1 - 0.00081 18.8 0.1 0.0017 17.7 0.1 1.4 1 1 0 1 1 1 1 WD40-like domain F-box-like PF12937.7 PIK36842.1 - 6.1e-12 45.2 0.1 1.3e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK36842.1 - 1.4e-08 34.4 0.2 2.1e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 PIK36842.1 - 0.034 13.7 0.5 0.11 12.0 0.5 1.8 1 1 0 1 1 1 0 F-box NACHT PF05729.12 PIK36843.1 - 4e-18 65.9 0.0 8e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK36843.1 - 0.00074 19.9 0.1 0.019 15.3 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 PIK36843.1 - 0.0047 16.5 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK36843.1 - 0.0073 16.6 0.1 0.032 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain DAP3 PF10236.9 PIK36843.1 - 0.034 13.3 0.0 0.079 12.1 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Anillin PF08174.11 PIK36843.1 - 0.21 12.0 2.5 2.7 8.4 0.1 2.4 2 0 0 2 2 2 0 Cell division protein anillin ZU5 PF00791.20 PIK36846.1 - 1.9e-14 53.8 0.0 3.4e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK36846.1 - 3.1e-13 49.7 0.2 1.3e-12 47.7 0.1 1.9 2 0 0 2 2 2 1 Death domain WD40 PF00400.32 PIK36848.1 - 5.8e-37 125.1 19.2 1.1e-08 35.5 0.8 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK36848.1 - 6.7e-09 35.9 1.9 0.0015 18.7 0.1 4.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 PIK36848.1 - 2.9e-08 33.4 2.2 5.7e-08 32.4 2.2 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK36848.1 - 5.1e-07 29.5 2.2 1.2e-06 28.3 2.2 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 PIK36848.1 - 6.7e-06 25.0 6.0 0.47 9.0 0.0 4.5 3 2 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK36848.1 - 0.00052 19.4 0.0 0.0063 15.9 0.0 2.4 1 1 0 2 2 2 1 WD40-like domain Nucleoporin_N PF08801.11 PIK36848.1 - 0.016 14.0 0.5 4.8 5.8 0.0 3.1 2 2 0 3 3 3 0 Nup133 N terminal like DUF4508 PF14969.6 PIK36848.1 - 0.061 13.6 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) UPRTase PF14681.6 PIK36849.1 - 0.0091 15.5 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase RT_RNaseH_2 PF17919.1 PIK36850.1 - 2.6e-12 46.6 0.0 4.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36850.1 - 0.081 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DUF5498 PF17602.2 PIK36850.1 - 0.12 12.9 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5498) rve PF00665.26 PIK36851.1 - 7e-19 68.2 0.0 1.3e-18 67.3 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK36851.1 - 3.1e-14 52.8 1.7 4.8e-14 52.2 1.7 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Sushi PF00084.20 PIK36852.1 - 7.7e-16 58.4 25.1 5.7e-09 36.4 1.3 6.7 7 1 0 7 7 7 4 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK36852.1 - 4.7e-08 33.5 5.1 0.00017 22.1 0.1 4.1 4 0 0 4 4 4 2 Immunoglobulin domain F5_F8_type_C PF00754.25 PIK36852.1 - 1.3e-07 31.8 0.3 5.7e-07 29.7 0.2 2.1 2 0 0 2 2 2 1 F5/8 type C domain ig PF00047.25 PIK36852.1 - 1.7e-06 28.1 2.1 0.00058 20.0 0.1 3.6 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK36852.1 - 7.4e-06 26.2 4.8 0.045 14.1 0.0 3.5 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK36852.1 - 0.00015 21.9 1.4 0.26 11.5 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK36852.1 - 0.0027 18.0 0.3 6.3 7.1 0.0 3.6 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK36852.1 - 0.0048 16.9 0.1 1.6 8.9 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Sin3_corepress PF08295.12 PIK36852.1 - 0.16 12.1 0.0 2.4 8.3 0.0 2.5 3 0 0 3 3 3 0 Sin3 family co-repressor Sushi PF00084.20 PIK36853.1 - 2.2e-10 41.0 8.8 8.8e-07 29.4 2.4 3.5 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK36853.1 - 0.00054 20.5 1.3 0.0087 16.6 0.2 2.6 3 0 0 3 3 3 1 Immunoglobulin domain HRM PF02793.22 PIK36853.1 - 0.00069 19.9 5.0 0.35 11.2 0.2 3.6 4 0 0 4 4 4 2 Hormone receptor domain Ig_2 PF13895.6 PIK36853.1 - 0.0026 18.0 0.4 0.0026 18.0 0.4 2.6 3 1 1 4 4 4 1 Immunoglobulin domain SoxE PF06525.11 PIK36853.1 - 0.0067 15.9 0.1 0.012 15.1 0.1 1.4 1 1 0 1 1 1 1 Sulfocyanin (SoxE) domain ig PF00047.25 PIK36853.1 - 0.016 15.4 1.2 0.19 11.9 0.3 2.8 3 1 0 3 3 3 0 Immunoglobulin domain zf-C2HC PF01530.18 PIK36853.1 - 0.038 14.2 0.6 0.1 12.8 0.2 2.0 2 0 0 2 2 2 0 Zinc finger, C2HC type Adap_comp_sub PF00928.21 PIK36853.1 - 0.061 12.7 0.1 0.092 12.1 0.1 1.3 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Peptidase_M1_N PF17900.1 PIK36854.1 - 7.5e-15 55.6 0.0 1.1e-14 55.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 PIK36854.1 - 6.6e-07 29.1 0.0 1.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Med1 PF10744.9 PIK36854.1 - 0.12 11.4 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 Leuk-A4-hydro_C PF09127.11 PIK36855.1 - 2.6e-24 85.5 0.6 3e-24 85.3 0.6 1.0 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Inhibitor_G39P PF11417.8 PIK36855.1 - 0.067 13.7 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 Loader and inhibitor of phage G40P DUF1011 PF06237.12 PIK36856.1 - 7.8e-24 83.9 2.3 7.8e-24 83.9 2.3 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) 2-Hacid_dh_C PF02826.19 PIK36857.1 - 1.7e-58 196.9 0.0 2.2e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK36857.1 - 7.9e-18 64.4 0.0 1e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 PIK36857.1 - 2.5e-06 27.8 0.0 4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 PIK36857.1 - 0.052 13.6 0.2 0.54 10.3 0.1 2.3 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FAD_binding_3 PF01494.19 PIK36858.1 - 7.8e-05 22.1 0.0 0.00019 20.8 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 PIK36858.1 - 0.0014 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 PIK36858.1 - 0.0045 16.3 0.0 0.0071 15.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK36858.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 PIK36858.1 - 0.071 12.4 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK36858.1 - 0.077 12.1 0.1 0.14 11.2 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 PIK36858.1 - 0.091 12.3 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Ldh_1_N PF00056.23 PIK36858.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 PIK36858.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK36858.1 - 0.15 10.7 0.0 0.28 9.8 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Glyco_transf_7N PF13733.6 PIK36859.1 - 3.3e-49 166.0 0.1 4.9e-49 165.4 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Lipoprotein_21 PF14041.6 PIK36860.1 - 0.018 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 LppP/LprE lipoprotein Spindle_Spc25 PF08234.12 PIK36860.1 - 0.044 14.0 0.7 0.44 10.8 0.0 2.5 3 0 0 3 3 3 0 Chromosome segregation protein Spc25 WD-3 PF09765.9 PIK36860.1 - 0.054 12.8 0.0 0.083 12.2 0.0 1.3 1 0 0 1 1 1 0 WD-repeat region Ank_2 PF12796.7 PIK36861.1 - 1.5e-10 41.5 0.1 4.9e-10 39.9 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK36861.1 - 1e-07 32.4 0.0 1.7e-05 25.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK36861.1 - 1e-07 31.6 0.0 0.17 12.5 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 PIK36861.1 - 1.8e-07 31.3 0.3 0.081 13.4 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK36861.1 - 5.4e-06 26.6 0.4 0.00012 22.3 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) NPL PF17800.1 PIK36862.1 - 1.6e-08 35.0 0.1 2.7e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-C2H2_4 PF13894.6 PIK36863.1 - 1.2e-16 60.0 63.5 0.0013 19.4 2.0 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK36863.1 - 3.7e-15 55.4 66.8 3e-05 24.2 4.0 8.5 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK36863.1 - 6.5e-14 51.6 72.9 4.3e-07 30.1 0.4 9.6 10 0 0 10 10 10 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK36863.1 - 0.00023 21.1 2.8 0.00023 21.1 2.8 7.2 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK36863.1 - 0.00071 19.8 48.5 0.25 11.7 0.8 8.1 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK36863.1 - 0.013 15.9 9.3 0.031 14.7 1.7 6.5 7 0 0 7 7 7 0 Zinc-finger of C2H2 type DUF3268 PF11672.8 PIK36863.1 - 0.082 13.2 17.0 0.26 11.6 1.0 3.6 4 0 0 4 4 4 0 zinc-finger-containing domain BolA PF01722.18 PIK36863.1 - 0.26 11.6 5.5 1.9 8.8 0.1 3.1 3 0 0 3 3 3 0 BolA-like protein zf-CHCC PF10276.9 PIK36863.1 - 1.5 8.9 11.6 0.36 10.9 0.4 4.2 4 0 0 4 4 4 0 Zinc-finger domain Desulfoferrod_N PF06397.12 PIK36863.1 - 8 6.2 5.9 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain Tetraspanin PF00335.20 PIK36864.1 - 1.6e-06 28.0 0.1 1.7e-06 27.9 0.1 1.0 1 0 0 1 1 1 1 Tetraspanin family Tetraspanin PF00335.20 PIK36865.1 - 1.8e-37 129.3 6.8 2e-37 129.1 6.8 1.1 1 0 0 1 1 1 1 Tetraspanin family GST_N PF02798.20 PIK36867.1 - 4.2e-08 33.4 0.0 9e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK36867.1 - 7.4e-05 22.9 0.1 0.00012 22.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK36867.1 - 0.00038 20.8 0.0 0.00077 19.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK36867.1 - 0.0015 18.8 0.0 0.0025 18.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Epimerase PF01370.21 PIK36868.1 - 0.0046 16.4 0.3 0.009 15.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 PIK36869.1 - 6.2e-34 117.6 15.1 7.7e-34 117.3 15.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK36869.1 - 7.3e-25 87.6 47.2 1.3e-21 77.0 26.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Afaf PF15339.6 PIK36870.1 - 0.011 15.5 8.0 0.015 15.0 8.0 1.3 1 0 0 1 1 1 0 Acrosome formation-associated factor ATHILA PF03078.15 PIK36870.1 - 0.39 9.5 11.7 0.49 9.1 11.3 1.2 1 1 0 1 1 1 0 ATHILA ORF-1 family RR_TM4-6 PF06459.12 PIK36870.1 - 1.8 8.3 17.0 2.5 7.9 17.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spot_14 PF07084.12 PIK36872.1 - 3.9e-21 75.8 0.3 8.2e-21 74.7 0.3 1.5 1 1 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Arylesterase PF01731.20 PIK36873.1 - 0.00042 20.5 0.0 0.0008 19.6 0.0 1.5 1 0 0 1 1 1 1 Arylesterase Lactonase PF10282.9 PIK36874.1 - 0.0093 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.20 PIK36875.1 - 0.0073 16.5 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 Arylesterase Arylesterase PF01731.20 PIK36876.1 - 1.5e-19 70.0 0.0 3.3e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 PIK36876.1 - 2.3e-08 33.9 0.1 5.2e-08 32.8 0.1 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 PIK36876.1 - 0.0075 16.4 0.0 0.043 13.9 0.0 2.3 2 1 0 2 2 2 1 Strictosidine synthase 5_nucleotid PF05761.14 PIK36877.1 - 6e-114 381.4 0.4 7.8e-114 381.1 0.4 1.1 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 PIK36877.1 - 0.035 14.2 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase LexA_DNA_bind PF01726.16 PIK36877.1 - 0.1 12.4 0.0 6.2 6.7 0.0 2.5 2 0 0 2 2 2 0 LexA DNA binding domain Nnf1 PF03980.14 PIK36878.1 - 0.015 15.7 0.2 0.015 15.7 0.2 2.8 2 1 1 3 3 3 0 Nnf1 DUF4407 PF14362.6 PIK36878.1 - 0.11 11.8 4.5 0.16 11.3 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_23 PF13476.6 PIK36878.1 - 3.3 8.2 11.8 5.1 7.5 11.8 1.3 1 1 0 1 1 1 0 AAA domain TLD PF07534.16 PIK36879.1 - 1.7e-21 76.9 0.0 1.8e-20 73.6 0.0 2.2 2 0 0 2 2 2 1 TLD RabGAP-TBC PF00566.18 PIK36879.1 - 4.5e-19 69.0 1.1 6.7e-19 68.4 1.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4498 PF14926.6 PIK36880.1 - 2.2e-76 256.5 2.5 2.4e-76 256.3 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) Med6 PF04934.14 PIK36881.1 - 8.4e-41 138.9 0.2 1.2e-40 138.4 0.2 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component IGFL PF14653.6 PIK36883.1 - 0.008 16.1 2.9 0.008 16.1 2.9 11.0 5 4 3 12 12 12 4 Insulin growth factor-like family AF-4 PF05110.13 PIK36885.1 - 0.097 10.8 5.4 0.12 10.5 5.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMUP PF15761.5 PIK36885.1 - 1.5 9.5 4.7 2.3 9.0 4.7 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein Pacs-1 PF10254.9 PIK36886.1 - 3e-74 250.4 0.4 3.4e-74 250.3 0.4 1.0 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein PD40 PF07676.12 PIK36887.1 - 0.01 15.7 1.1 0.017 15.0 0.2 1.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat HIF-1 PF11413.8 PIK36888.1 - 0.057 12.8 5.3 0.077 12.4 4.0 1.9 2 0 0 2 2 2 0 Hypoxia-inducible factor-1 PAS_11 PF14598.6 PIK36889.1 - 4.9e-23 81.4 0.4 2.7e-21 75.8 0.1 3.1 2 1 1 3 3 3 1 PAS domain PAS_3 PF08447.12 PIK36889.1 - 6.8e-21 74.4 0.3 2.8e-19 69.2 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 PIK36889.1 - 1.8e-08 34.4 0.2 0.00014 21.8 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 PIK36889.1 - 5.7e-06 26.5 0.0 3.1e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 PIK36889.1 - 9.4e-05 22.6 0.0 0.0011 19.2 0.0 2.2 2 0 0 2 2 2 1 PAS fold UPF0489 PF12640.7 PIK36890.1 - 2.5e-46 158.1 2.9 2.9e-46 157.9 2.9 1.2 1 0 0 1 1 1 1 UPF0489 domain DNApol_Exo PF18136.1 PIK36890.1 - 0.004 16.3 0.2 0.0052 16.0 0.2 1.1 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain Rotamase_2 PF13145.6 PIK36891.1 - 0.026 15.4 0.3 0.063 14.1 0.0 1.7 2 0 0 2 2 2 0 PPIC-type PPIASE domain PUF PF00806.19 PIK36892.1 - 6.1e-17 60.3 4.2 0.035 13.8 0.0 8.8 9 0 0 9 9 9 6 Pumilio-family RNA binding repeat DNA_pol_E_B PF04042.16 PIK36892.1 - 0.11 11.8 0.3 26 4.1 0.0 3.1 3 0 0 3 3 3 0 DNA polymerase alpha/epsilon subunit B Pkinase PF00069.25 PIK36893.1 - 7.1e-09 35.4 0.1 8.9e-09 35.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36893.1 - 3.6e-08 33.0 0.0 4.3e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 PIK36893.1 - 0.092 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 ABC1 family Pkinase PF00069.25 PIK36894.1 - 5.9e-40 137.3 0.0 7.9e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36894.1 - 1.8e-28 99.5 0.0 2.9e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK36894.1 - 0.0045 15.8 0.0 0.0074 15.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Homeodomain PF00046.29 PIK36896.1 - 1.5e-09 37.5 0.7 2.6e-09 36.8 0.7 1.4 1 0 0 1 1 1 1 Homeodomain DFRP_C PF16543.5 PIK36896.1 - 0.038 14.5 0.5 0.062 13.8 0.5 1.3 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 STAC2_u1 PF16664.5 PIK36896.1 - 0.16 12.4 3.0 0.27 11.7 3.0 1.4 1 1 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 MARVEL PF01284.23 PIK36898.1 - 1.4e-05 25.1 14.6 4.5e-05 23.5 14.6 1.9 1 1 0 1 1 1 1 Membrane-associating domain DUF2417 PF10329.9 PIK36898.1 - 0.044 13.2 7.3 0.05 13.0 7.3 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF2070 PF09843.9 PIK36898.1 - 1 7.6 11.3 1.2 7.4 11.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MutS_V PF00488.21 PIK36899.1 - 2e-46 158.4 0.3 2.7e-39 135.2 0.0 2.7 1 1 1 2 2 2 2 MutS domain V MutS_III PF05192.18 PIK36899.1 - 6.1e-27 95.1 4.0 6.1e-27 95.1 4.0 1.6 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 PIK36899.1 - 1.3e-20 73.5 0.7 3.8e-20 72.0 0.7 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 PIK36899.1 - 9.5e-12 45.2 0.1 2.4e-11 43.8 0.1 1.7 1 0 0 1 1 1 1 MutS domain I AAA_27 PF13514.6 PIK36899.1 - 0.0017 18.0 0.0 0.0052 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain MutS_II PF05188.17 PIK36899.1 - 0.0054 17.0 1.9 0.019 15.2 0.0 2.9 4 0 0 4 4 4 1 MutS domain II PCRF PF03462.18 PIK36899.1 - 0.4 10.5 2.3 25 4.7 0.2 2.7 2 0 0 2 2 2 0 PCRF domain DSPc PF00782.20 PIK36900.1 - 2.7e-37 127.5 0.0 3.3e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK36900.1 - 0.00017 21.2 0.1 0.00021 20.9 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK36900.1 - 0.0022 18.1 0.0 0.0034 17.5 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate 7tm_3 PF00003.22 PIK36901.1 - 2.4e-40 138.7 20.2 3.3e-40 138.3 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NHL PF01436.21 PIK36903.1 - 2.2e-12 46.3 0.2 6.7e-06 25.9 0.0 4.6 4 0 0 4 4 4 3 NHL repeat SGL PF08450.12 PIK36903.1 - 0.001 18.7 0.0 0.47 10.0 0.0 2.2 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 PIK36903.1 - 0.0039 17.2 0.2 0.82 9.7 0.0 2.6 2 0 0 2 2 2 1 Beta-propeller repeat SdiA-regulated PF06977.11 PIK36903.1 - 0.0062 15.8 0.0 0.16 11.1 0.0 2.6 2 1 1 3 3 3 1 SdiA-regulated DUF5128 PF17170.4 PIK36903.1 - 0.035 13.3 0.1 0.041 13.0 0.1 1.2 1 0 0 1 1 1 0 6-bladed beta-propeller PFU PF09070.11 PIK36903.1 - 0.06 13.6 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) Rib_hydrolayse PF02267.17 PIK36903.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosyl cyclase RVT_1 PF00078.27 PIK36905.1 - 9.2e-44 149.6 0.8 9.1e-43 146.3 0.0 2.7 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK36905.1 - 1.4e-09 38.5 1.1 1.4e-09 38.5 1.1 2.7 3 0 0 3 3 3 1 zinc-binding in reverse transcriptase NHL PF01436.21 PIK36906.1 - 9.1e-12 44.4 5.0 1.3e-05 25.0 0.0 6.3 6 0 0 6 6 6 2 NHL repeat zf-C3HC4_2 PF13923.6 PIK36906.1 - 1.3e-09 37.8 10.2 2.5e-09 36.8 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK36906.1 - 2.8e-09 36.7 8.9 5.3e-09 35.8 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK36906.1 - 7.7e-09 35.4 5.8 1.6e-08 34.5 5.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK36906.1 - 1.2e-08 35.2 8.3 1.2e-08 35.2 8.3 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK36906.1 - 1.3e-08 34.5 7.3 2.6e-08 33.6 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK36906.1 - 6.1e-08 32.7 8.5 1.3e-07 31.6 8.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SGL PF08450.12 PIK36906.1 - 7.2e-07 29.0 0.1 0.003 17.2 0.0 2.4 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Prok-RING_4 PF14447.6 PIK36906.1 - 6.4e-06 25.9 7.3 2.2e-05 24.2 7.4 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 SBBP PF06739.11 PIK36906.1 - 8.8e-06 25.6 0.1 0.026 14.5 0.0 2.9 2 0 0 2 2 2 2 Beta-propeller repeat zf-RING_5 PF14634.6 PIK36906.1 - 2.1e-05 24.4 7.0 5.3e-05 23.1 7.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain DUF5128 PF17170.4 PIK36906.1 - 0.00043 19.5 0.1 0.027 13.6 0.0 2.4 2 0 0 2 2 2 1 6-bladed beta-propeller Filamin PF00630.19 PIK36906.1 - 0.0019 19.0 0.0 0.0054 17.5 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat SdiA-regulated PF06977.11 PIK36906.1 - 0.0081 15.4 0.0 0.63 9.2 0.0 2.3 2 0 0 2 2 2 1 SdiA-regulated zf-RING_10 PF16685.5 PIK36906.1 - 0.013 15.6 7.7 0.025 14.7 7.7 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-UDP PF14569.6 PIK36906.1 - 0.03 14.4 3.9 1.1 9.4 4.4 2.7 2 1 0 2 2 2 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 PIK36906.1 - 0.053 13.1 3.3 0.18 11.5 3.3 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type ANAPC4_WD40 PF12894.7 PIK36906.1 - 0.059 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_4 PF14570.6 PIK36906.1 - 0.14 12.0 5.9 0.34 10.7 5.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain HypA PF01155.19 PIK36906.1 - 0.14 12.2 2.6 0.29 11.2 2.6 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lactonase PF10282.9 PIK36906.1 - 0.17 11.1 0.1 0.3 10.3 0.1 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller zf-rbx1 PF12678.7 PIK36906.1 - 0.51 10.7 9.2 2.8 8.3 9.3 2.1 1 1 1 2 2 2 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 PIK36906.1 - 2.1 8.4 6.5 4.4 7.4 6.5 1.5 1 0 0 1 1 1 0 zinc-ribbons NHL PF01436.21 PIK36907.1 - 6.4e-12 44.9 2.4 9e-06 25.5 0.0 4.5 4 0 0 4 4 4 3 NHL repeat zf-C3HC4_2 PF13923.6 PIK36907.1 - 3.1e-09 36.5 9.7 3.1e-09 36.5 9.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK36907.1 - 3.4e-09 36.6 5.0 9.5e-09 35.1 5.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK36907.1 - 5.1e-09 35.9 8.4 5.1e-09 35.9 8.4 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK36907.1 - 1.2e-08 35.2 7.9 1.2e-08 35.2 7.9 2.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK36907.1 - 2e-08 33.9 7.1 2e-08 33.9 7.1 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK36907.1 - 1.5e-07 31.5 8.2 1.5e-07 31.5 8.2 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK36907.1 - 2.8e-05 23.9 7.5 2.8e-05 23.9 7.5 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK36907.1 - 4.8e-05 23.2 6.6 4.8e-05 23.2 6.6 2.8 3 0 0 3 3 3 1 zinc-RING finger domain DUF5128 PF17170.4 PIK36907.1 - 0.0021 17.3 0.6 0.071 12.3 0.1 2.4 2 0 0 2 2 2 1 6-bladed beta-propeller Filamin PF00630.19 PIK36907.1 - 0.0026 18.5 0.0 0.0064 17.3 0.0 1.8 1 1 0 1 1 1 1 Filamin/ABP280 repeat SGL PF08450.12 PIK36907.1 - 0.0077 15.8 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 PIK36907.1 - 0.025 14.6 0.1 0.071 13.1 0.1 1.8 1 0 0 1 1 1 0 Beta-propeller repeat zf-RING_10 PF16685.5 PIK36907.1 - 0.04 14.1 14.1 0.037 14.2 7.8 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 ANAPC4_WD40 PF12894.7 PIK36907.1 - 0.04 14.2 0.1 0.09 13.1 0.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4677 PF15726.5 PIK36907.1 - 0.083 13.0 0.3 0.16 12.1 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) zf-UDP PF14569.6 PIK36907.1 - 0.18 11.9 4.2 2.3 8.4 4.0 2.7 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 PIK36907.1 - 1.5 8.7 13.0 0.76 9.6 6.5 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain HypA PF01155.19 PIK36907.1 - 9 6.4 9.0 0.41 10.7 2.7 2.0 2 0 0 2 2 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PhyH PF05721.13 PIK36908.1 - 8.8e-46 156.8 0.0 1.1e-45 156.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 PIK36908.1 - 0.033 12.9 0.0 12 4.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1479) EntA_Immun PF08951.10 PIK36908.1 - 0.54 10.7 2.6 6.8 7.1 0.2 2.6 2 0 0 2 2 2 0 Enterocin A Immunity GDWWSH PF15667.5 PIK36909.1 - 1.9e-16 60.3 0.4 2.2e-16 60.1 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function with motif GDWWSH Glucosamine_iso PF01182.20 PIK36910.1 - 9.2e-21 74.7 0.0 1.2e-20 74.4 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Torsin PF06309.11 PIK36911.1 - 0.17 12.0 0.0 0.18 11.9 0.0 1.0 1 0 0 1 1 1 0 Torsin AAA_2 PF07724.14 PIK36912.1 - 1.9e-12 47.6 0.2 4.2e-12 46.5 0.2 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Olfactory_mark PF06554.12 PIK36912.1 - 0.00083 19.1 0.5 0.0013 18.5 0.4 1.4 1 1 0 1 1 1 1 Olfactory marker protein PKS_DE PF18369.1 PIK36912.1 - 0.093 13.3 0.4 0.21 12.2 0.1 1.7 2 0 0 2 2 2 0 Polyketide synthase dimerisation element domain Rad17 PF03215.15 PIK36913.1 - 2.1e-05 24.5 0.2 7.8e-05 22.7 0.0 2.0 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 PIK36913.1 - 0.0057 17.1 0.0 0.0098 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Rep_fac_C PF08542.11 PIK36913.1 - 0.024 15.1 0.1 0.06 13.8 0.1 1.7 1 0 0 1 1 1 0 Replication factor C C-terminal domain ABC_tran PF00005.27 PIK36913.1 - 0.044 14.3 0.1 0.11 13.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter T4SS-DNA_transf PF02534.14 PIK36913.1 - 0.084 11.7 0.0 0.18 10.5 0.0 1.5 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AZUL PF16558.5 PIK36914.1 - 3.7e-15 55.9 2.0 7.2e-15 55.0 2.0 1.5 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A DASH_Dad2 PF08654.10 PIK36914.1 - 0.13 12.7 0.3 0.13 12.7 0.3 2.8 3 0 0 3 3 3 0 DASH complex subunit Dad2 Ribonuc_P_40 PF08584.11 PIK36914.1 - 0.31 10.3 2.9 2.2 7.5 0.2 2.1 1 1 1 2 2 2 0 Ribonuclease P 40kDa (Rpp40) subunit HECT PF00632.25 PIK36915.1 - 1.9e-86 290.3 0.4 2.3e-86 290.1 0.4 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 PIK36918.1 - 2.5e-07 29.9 0.9 6.7e-07 28.6 0.9 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Connexin PF00029.19 PIK36918.1 - 1.3 8.7 5.8 2.5 7.8 5.8 1.4 1 0 0 1 1 1 0 Connexin Hist_deacetyl PF00850.19 PIK36919.1 - 1.4e-09 37.9 0.0 1.6e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain LisH PF08513.11 PIK36919.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 LisH Hist_deacetyl PF00850.19 PIK36920.1 - 2.5e-29 102.7 0.1 4.7e-29 101.8 0.1 1.5 1 1 0 1 1 1 1 Histone deacetylase domain SH2 PF00017.24 PIK36921.1 - 1.8e-18 66.4 0.1 5e-18 65.0 0.1 1.8 2 0 0 2 2 2 1 SH2 domain Pkinase_Tyr PF07714.17 PIK36921.1 - 5.3e-14 52.1 0.0 8.6e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36921.1 - 9.2e-11 41.6 0.0 1.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36922.1 - 4.6e-30 104.8 0.1 5.5e-30 104.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36922.1 - 3.2e-08 33.3 0.0 4e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Galactosyl_T PF01762.21 PIK36923.1 - 5.9e-38 130.7 0.1 7.2e-38 130.4 0.1 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK36923.1 - 0.017 14.6 0.2 0.058 12.8 0.2 1.7 1 1 0 1 1 1 0 Fringe-like Guanylate_kin PF00625.21 PIK36925.1 - 2.9e-29 102.1 0.7 5.1e-29 101.2 0.7 1.4 1 0 0 1 1 1 1 Guanylate kinase Amidase PF01425.21 PIK36926.1 - 1.7e-36 126.2 0.2 9.7e-32 110.5 0.3 2.0 2 0 0 2 2 2 2 Amidase FKBP_C PF00254.28 PIK36927.1 - 0.0045 17.3 0.0 0.0058 16.9 0.0 1.4 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Peptidase_C98 PF15499.6 PIK36928.1 - 7e-57 193.0 0.8 1.4e-56 192.0 0.8 1.5 1 0 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase NES_C_h PF18208.1 PIK36928.1 - 0.15 12.4 0.6 3.2 8.1 0.1 2.5 2 0 0 2 2 2 0 Nicking enzyme C-terminal middle helical domain GP40 PF11025.8 PIK36928.1 - 0.16 11.8 0.7 0.3 10.8 0.7 1.4 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium ACOX PF01756.19 PIK36929.1 - 2.1e-57 193.6 0.1 3.4e-57 192.9 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 PIK36929.1 - 9.2e-11 41.8 0.0 4.4e-10 39.6 0.0 2.2 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 PIK36929.1 - 3.6e-06 27.6 1.0 7.1e-06 26.6 1.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal ATP-cone PF03477.16 PIK36930.1 - 1.5 9.5 8.2 0.63 10.7 0.9 2.6 3 0 0 3 3 3 0 ATP cone domain DNA_pol_B_2 PF03175.13 PIK36931.1 - 6.8e-55 186.8 14.2 1.7e-25 89.8 4.9 3.1 2 1 1 3 3 3 3 DNA polymerase type B, organellar and viral DUF5338 PF17273.2 PIK36931.1 - 0.012 15.6 0.3 1.5 8.9 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5338) Sulfatase PF00884.23 PIK36932.1 - 3e-57 194.4 0.0 1.4e-55 188.8 0.0 2.1 1 1 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK36932.1 - 0.0025 18.6 0.0 0.0047 17.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF229 PF02995.17 PIK36932.1 - 0.17 10.5 0.0 0.92 8.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF229) Phosphodiest PF01663.22 PIK36932.1 - 0.19 11.3 0.5 2.4 7.6 0.5 2.0 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase IATP PF04568.12 PIK36933.1 - 3e-27 94.9 1.8 4.1e-27 94.5 1.8 1.3 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP TMPIT PF07851.13 PIK36933.1 - 0.83 8.8 3.2 1.2 8.3 3.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4337 PF14235.6 PIK36933.1 - 2.5 8.2 6.5 3.5 7.7 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) CREPT PF16566.5 PIK36933.1 - 3.5 7.8 7.2 4.8 7.3 7.2 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour 7tm_2 PF00002.24 PIK36934.1 - 9e-25 87.4 15.9 1.4e-24 86.7 15.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) eIF-6 PF01912.18 PIK36935.1 - 7.6e-81 270.2 0.2 1.2e-80 269.6 0.2 1.3 1 0 0 1 1 1 1 eIF-6 family CAP PF00188.26 PIK36936.1 - 6.7e-17 62.5 0.4 6.7e-17 62.5 0.4 1.7 2 0 0 2 2 2 1 Cysteine-rich secretory protein family MG3 PF17791.1 PIK36937.1 - 2.9e-19 69.1 0.0 1.1e-18 67.3 0.0 2.0 1 0 0 1 1 1 1 Macroglobulin domain MG3 MG2 PF01835.19 PIK36937.1 - 1.3e-14 54.4 0.0 1.6e-13 50.9 0.0 2.6 3 0 0 3 3 3 1 MG2 domain MG4 PF17789.1 PIK36937.1 - 1.3e-07 31.7 0.3 0.0021 18.1 0.0 4.2 4 0 0 4 4 4 2 Macroglobulin domain MG4 A2M_BRD PF07703.14 PIK36937.1 - 0.0024 18.2 0.3 0.066 13.6 0.0 2.9 2 1 1 3 3 3 1 Alpha-2-macroglobulin bait region domain MG1 PF17790.1 PIK36937.1 - 0.0033 17.8 0.0 0.013 15.9 0.0 2.0 2 0 0 2 2 2 1 Macroglobulin domain MG1 Glyco_hydro_66 PF13199.6 PIK36937.1 - 0.044 12.4 0.0 0.063 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 TED_complement PF07678.14 PIK36938.1 - 1.5e-85 287.0 0.0 2.1e-85 286.5 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 PIK36938.1 - 3.5e-29 100.5 0.5 7.3e-29 99.5 0.5 1.6 1 0 0 1 1 1 1 Alpha-2-macroglobulin family GIY-YIG PF01541.24 PIK36940.1 - 3.2e-06 27.3 0.0 6.5e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 GIY-YIG catalytic domain Lamp PF01299.17 PIK36942.1 - 0.0086 15.9 0.1 0.016 15.0 0.1 1.4 1 1 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) LapA_dom PF06305.11 PIK36942.1 - 0.5 10.2 2.1 1 9.2 2.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4083 PF13314.6 PIK36942.1 - 0.5 10.3 3.4 0.74 9.8 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Mo25 PF08569.11 PIK36943.1 - 2e-97 326.5 14.2 2.2e-97 326.4 14.2 1.0 1 0 0 1 1 1 1 Mo25-like HEAT_2 PF13646.6 PIK36943.1 - 0.031 14.7 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 HEAT repeats Peptidase_S10 PF00450.22 PIK36944.1 - 9.7e-89 298.7 1.3 1.1e-88 298.5 1.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 PIK36944.1 - 0.0094 15.2 0.0 0.23 10.7 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 eIF2A PF08662.11 PIK36945.1 - 1.3e-33 116.5 8.3 4.3e-15 56.1 0.5 6.0 3 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 PIK36945.1 - 2.8 8.9 9.9 15 6.7 3.2 4.3 3 1 1 4 4 4 0 WD domain, G-beta repeat Mito_carr PF00153.27 PIK36946.1 - 2.1e-66 219.9 0.9 4.8e-23 80.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3764 PF12594.8 PIK36946.1 - 0.038 14.0 0.0 0.79 9.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) fn3_4 PF16794.5 PIK36947.1 - 3.3e-26 91.2 0.0 7.1e-26 90.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin-III type domain EnY2 PF10163.9 PIK36947.1 - 1.3 9.5 7.3 2.5 8.5 2.6 2.9 2 0 0 2 2 2 0 Transcription factor e(y)2 zf-CCHC_3 PF13917.6 PIK36948.1 - 4.8e-17 61.6 2.1 7.4e-17 61.0 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK36948.1 - 0.039 14.0 0.7 0.062 13.4 0.7 1.3 1 0 0 1 1 1 0 Zinc knuckle SDA1 PF05285.12 PIK36948.1 - 0.1 12.0 24.3 0.1 12.0 24.3 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 PIK36948.1 - 0.12 11.7 31.6 0.13 11.6 31.6 1.1 1 0 0 1 1 1 0 BUD22 LRRFIP PF09738.9 PIK36948.1 - 0.38 10.2 16.9 0.68 9.4 16.9 1.4 1 0 0 1 1 1 0 LRRFIP family Macoilin PF09726.9 PIK36948.1 - 0.75 8.3 22.6 0.82 8.2 22.6 1.0 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 PIK36948.1 - 1.2 6.8 21.0 1.2 6.8 21.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RAP1 PF07218.11 PIK36948.1 - 2.6 6.2 19.6 2.8 6.1 19.6 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDC45 PF02724.14 PIK36948.1 - 3.4 5.9 22.3 3.7 5.7 22.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 PIK36948.1 - 4.3 5.4 23.3 4.3 5.4 23.3 1.1 1 0 0 1 1 1 0 Nop14-like family PNISR PF15996.5 PIK36948.1 - 6.2 7.0 16.4 6.8 6.9 16.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Peroxin-3 PF04882.12 PIK36948.1 - 7.5 5.4 18.1 8.8 5.2 18.1 1.1 1 0 0 1 1 1 0 Peroxin-3 Pkinase PF00069.25 PIK36949.1 - 2.4e-22 79.6 0.2 3.1e-22 79.2 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK36949.1 - 1.4e-12 47.5 0.1 1.8e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK36950.1 - 0.0029 17.0 0.0 0.0035 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK36951.1 - 4.7e-17 61.8 0.1 9.2e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 SH2 domain Fibrinogen_C PF00147.18 PIK36952.1 - 1.8e-66 224.1 9.9 5.4e-32 111.4 0.0 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK36952.1 - 1.2e-07 31.8 17.2 1.2e-07 31.8 17.2 3.4 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK36952.1 - 3.9e-05 23.5 2.2 3.9e-05 23.5 2.2 3.2 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK36952.1 - 0.00012 22.2 7.0 0.00012 22.2 7.0 3.7 3 0 0 3 3 3 1 EGF domain COLFI PF01410.18 PIK36952.1 - 0.00015 21.1 0.1 0.00032 20.1 0.1 1.5 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain cEGF PF12662.7 PIK36952.1 - 0.18 11.8 12.5 0.95 9.4 4.4 3.5 2 0 0 2 2 2 0 Complement Clr-like EGF-like NACHT PF05729.12 PIK36953.1 - 2.9e-07 30.5 0.0 6e-06 26.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain DUF4723 PF15851.5 PIK36953.1 - 0.0085 16.2 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4723) AAA_25 PF13481.6 PIK36953.1 - 0.018 14.6 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain PID_2 PF14719.6 PIK36954.1 - 2e-08 34.3 0.0 2.8e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 PIK36955.1 - 5.5e-13 49.2 0.0 8.7e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Rab5-bind PF09311.11 PIK36955.1 - 0.12 11.7 3.6 0.21 10.9 3.6 1.3 1 0 0 1 1 1 0 Rabaptin-like protein Patched PF02460.18 PIK36957.1 - 4e-14 51.7 40.6 1.9e-09 36.2 16.9 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 PIK36957.1 - 4.4e-13 49.3 12.7 4.4e-13 49.3 12.7 2.7 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation 30K_MP_C_Ter PF11330.8 PIK36957.1 - 0.094 12.0 0.3 0.2 11.0 0.3 1.4 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins MMPL PF03176.15 PIK36957.1 - 0.24 10.3 46.2 0.0084 15.1 15.8 2.6 2 2 0 2 2 2 0 MMPL family Propep_M14 PF02244.16 PIK36958.1 - 6e-14 52.2 0.2 1e-13 51.4 0.2 1.4 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Peptidase_M14 PF00246.24 PIK36959.1 - 7.3e-50 170.4 0.3 8.2e-50 170.2 0.3 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase SNF PF00209.18 PIK36960.1 - 8.4e-160 532.9 27.3 2.5e-98 330.0 8.2 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family WTF PF03303.13 PIK36960.1 - 0.055 13.2 3.7 2.1 8.0 0.1 2.5 2 0 0 2 2 2 0 WTF protein DUF563 PF04577.14 PIK36961.1 - 5.8e-05 23.3 0.3 0.00011 22.5 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF563) DUF570 PF04489.13 PIK36961.1 - 0.061 11.9 0.0 0.076 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF570) Glyco_hydro_47 PF01532.20 PIK36962.1 - 5.5e-116 388.2 0.0 1e-115 387.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DRMBL PF07522.14 PIK36963.1 - 4.2e-16 59.1 0.3 1.3e-15 57.5 0.3 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 PIK36963.1 - 0.00011 21.8 0.0 0.00052 19.6 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.12 PIK36963.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 PIK36964.1 - 0.00014 22.0 0.4 0.0017 18.4 0.4 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily UAA PF08449.11 PIK36965.1 - 6e-91 304.8 16.9 4.1e-90 302.0 16.9 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 PIK36965.1 - 0.087 13.0 24.4 0.062 13.5 12.1 3.0 2 1 0 3 3 3 0 EamA-like transporter family Gal-3-0_sulfotr PF06990.11 PIK36967.1 - 2.5e-63 214.3 0.3 3.2e-63 214.0 0.3 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Lectin_C PF00059.21 PIK36968.1 - 0.032 15.0 0.5 0.11 13.3 0.5 1.9 1 0 0 1 1 1 0 Lectin C-type domain PI-PLC-X PF00388.19 PIK36968.1 - 0.099 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain PH PF00169.29 PIK36969.1 - 0.021 15.3 0.0 0.044 14.3 0.0 1.6 1 0 0 1 1 1 0 PH domain TMF_TATA_bd PF12325.8 PIK36970.1 - 0.0024 18.1 5.8 0.023 14.9 1.1 2.1 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding DUF724 PF05266.14 PIK36970.1 - 0.012 15.4 1.5 0.02 14.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ApoB100_C PF12491.8 PIK36970.1 - 0.019 14.9 0.1 0.044 13.7 0.1 1.6 1 0 0 1 1 1 0 Apolipoprotein B100 C terminal HALZ PF02183.18 PIK36970.1 - 0.035 14.3 0.4 0.035 14.3 0.4 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper GreA_GreB_N PF03449.15 PIK36970.1 - 0.12 12.5 2.1 3 8.1 0.1 2.4 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal ABC_tran_CTD PF16326.5 PIK36970.1 - 0.14 12.4 2.7 0.2 11.9 0.5 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4315 PF14193.6 PIK36970.1 - 0.24 11.4 2.7 3 7.9 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4315) Pox_A_type_inc PF04508.12 PIK36970.1 - 6.4 6.8 7.2 12 5.9 0.1 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat RabGAP-TBC PF00566.18 PIK36971.1 - 2.6e-55 187.4 1.4 4.3e-55 186.7 1.4 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Sema PF01403.19 PIK36972.1 - 4.8e-17 61.9 0.0 9.3e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Sema domain TMEM154 PF15102.6 PIK36972.1 - 0.0092 15.9 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family EVI2A PF05399.11 PIK36972.1 - 0.041 13.5 0.0 0.09 12.4 0.0 1.5 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) TRIQK PF15168.6 PIK36972.1 - 0.058 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family UCH_1 PF13423.6 PIK36974.1 - 0.0038 16.9 0.2 0.1 12.2 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase WW PF00397.26 PIK36976.1 - 2.3e-12 46.8 0.2 5.5e-12 45.6 0.2 1.7 1 0 0 1 1 1 1 WW domain C2 PF00168.30 PIK36976.1 - 2.4e-12 47.0 0.0 6.1e-12 45.7 0.0 1.6 2 0 0 2 2 2 1 C2 domain HECT PF00632.25 PIK36977.1 - 6.2e-96 321.5 0.0 8e-96 321.1 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 PIK36977.1 - 1.2e-05 25.3 3.1 7.4e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 WW domain SNF PF00209.18 PIK36978.1 - 2e-30 106.0 5.5 2.3e-30 105.8 5.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF2046 PF09755.9 PIK36979.1 - 3.1e-110 368.2 55.3 3.9e-110 367.8 55.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 PIK36979.1 - 0.0022 18.3 48.1 0.018 15.3 24.3 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) zf-C2H2 PF00096.26 PIK36981.1 - 6e-14 51.6 19.2 9.6e-06 25.8 3.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36981.1 - 3.4e-12 46.1 18.9 5.8e-05 23.6 2.4 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK36981.1 - 1.1e-11 44.6 20.3 2.5e-07 30.8 0.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK36981.1 - 1.5e-05 24.9 20.6 0.025 14.6 1.9 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 PIK36981.1 - 5.9e-05 23.3 10.4 0.0021 18.4 1.7 3.2 3 0 0 3 3 2 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK36981.1 - 0.00065 19.8 4.4 0.4 10.8 0.7 2.5 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_jaz PF12171.8 PIK36981.1 - 0.0035 17.6 24.2 0.0043 17.3 0.2 4.1 5 0 0 5 5 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK36981.1 - 0.0037 17.2 4.5 8.5 6.4 0.1 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 PIK36981.1 - 0.0047 17.3 6.4 0.0047 17.3 6.4 3.5 1 1 2 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger Endonuclease_7 PF02945.15 PIK36981.1 - 0.0096 15.8 1.9 0.0096 15.8 1.9 2.3 1 1 1 2 2 2 1 Recombination endonuclease VII zf_ZIC PF18366.1 PIK36981.1 - 0.019 15.1 3.6 0.31 11.2 0.2 2.6 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_3rep PF18868.1 PIK36981.1 - 0.028 15.1 2.7 0.028 15.1 2.7 2.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK36981.1 - 0.028 14.7 6.3 0.053 13.8 4.7 2.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.7 PIK36981.1 - 0.03 14.6 14.3 0.41 11.0 1.3 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) C1_1 PF00130.22 PIK36981.1 - 0.033 14.1 10.0 1.4 8.9 0.4 3.2 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.14 PIK36981.1 - 0.049 13.6 0.9 0.049 13.6 0.9 1.9 2 0 0 2 2 1 0 Adenylate kinase, active site lid zf-FCS PF06467.14 PIK36981.1 - 0.07 13.1 7.7 0.25 11.3 4.2 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-MYST PF17772.1 PIK36981.1 - 0.18 11.5 0.3 0.18 11.5 0.3 3.0 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2H2_9 PF16293.5 PIK36981.1 - 0.26 11.2 2.0 2.6 8.0 0.1 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-CCHC_2 PF13696.6 PIK36981.1 - 0.34 10.8 7.8 1.6 8.7 1.7 2.5 2 0 0 2 2 2 0 Zinc knuckle zinc_ribbon_9 PF14369.6 PIK36981.1 - 0.45 10.8 8.3 0.6 10.4 0.1 2.8 2 1 0 2 2 2 0 zinc-ribbon zf-BED PF02892.15 PIK36981.1 - 0.71 9.9 14.2 0.092 12.8 2.7 3.3 1 1 2 3 3 3 0 BED zinc finger zf_UBZ PF18439.1 PIK36981.1 - 0.8 9.3 6.3 1.3 8.7 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 PIK36981.1 - 1.4 9.1 6.4 17 5.6 0.2 3.1 3 0 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_15 PF17032.5 PIK36981.1 - 1.6 9.5 8.1 0.51 11.1 2.0 2.3 1 1 2 3 3 3 0 zinc-ribbon family zf-C2HC_2 PF13913.6 PIK36981.1 - 3.1 7.8 6.4 23 5.0 0.6 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK36981.1 - 4.4 7.2 9.9 0.39 10.5 1.2 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zinc-ribbons_6 PF07191.12 PIK36981.1 - 5.1 7.1 8.0 1.7e+02 2.3 7.7 2.9 1 1 1 2 2 2 0 zinc-ribbons OrfB_IS605 PF01385.19 PIK36981.1 - 8.5 6.6 8.1 79 3.5 8.1 2.1 1 1 0 1 1 1 0 Probable transposase zf-H2C2_5 PF13909.6 PIK36981.1 - 9.6 6.1 18.4 0.089 12.6 1.7 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain NOT2_3_5 PF04153.18 PIK36982.1 - 2.8e-35 121.3 0.6 2.8e-35 121.3 0.6 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family LRRCT PF01463.24 PIK36984.1 - 0.029 14.9 0.7 0.079 13.5 0.7 1.8 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain DUF3149 PF11346.8 PIK36984.1 - 0.034 13.8 3.9 0.056 13.1 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Ig_3 PF13927.6 PIK36984.1 - 0.046 14.3 0.0 0.14 12.7 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain Aldo_ket_red PF00248.21 PIK36985.1 - 2.6e-53 181.1 0.0 3.7e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family PDZ PF00595.24 PIK36986.1 - 3e-10 40.3 0.0 1.7e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK36986.1 - 4.8e-05 23.1 0.3 0.00012 21.8 0.3 1.8 1 0 0 1 1 1 1 PDZ domain RebB PF11747.8 PIK36986.1 - 0.072 13.2 6.8 0.12 12.5 1.9 2.6 2 0 0 2 2 2 0 Killing trait PDZ_2 PF13180.6 PIK36986.1 - 0.079 13.3 2.4 0.12 12.8 0.1 2.5 2 0 0 2 2 2 0 PDZ domain MULE PF10551.9 PIK36987.1 - 1.9e-07 31.4 0.0 6.4e-07 29.7 0.0 2.0 1 0 0 1 1 1 1 MULE transposase domain SWIM PF04434.17 PIK36987.1 - 0.023 14.3 0.2 0.058 13.1 0.2 1.7 1 0 0 1 1 1 0 SWIM zinc finger rve PF00665.26 PIK36989.1 - 2.4e-16 60.0 0.0 8.8e-16 58.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK36989.1 - 0.0044 17.3 0.6 0.0072 16.6 0.3 1.5 1 1 0 1 1 1 1 DDE domain zf-C2H2 PF00096.26 PIK36990.1 - 4.5e-09 36.3 20.9 0.0023 18.3 0.8 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK36990.1 - 0.00096 19.8 19.4 0.013 16.3 0.6 4.6 3 0 0 3 3 3 2 C2H2-type zinc finger Vsr PF03852.15 PIK36990.1 - 0.021 14.6 0.2 0.057 13.3 0.2 1.7 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr zf-C2H2_8 PF15909.5 PIK36990.1 - 0.22 11.9 10.1 0.29 11.4 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 PIK36990.1 - 1.4 9.3 4.8 79 3.7 0.1 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK36990.1 - 2 8.2 7.9 8.9 6.2 0.3 3.3 3 0 0 3 3 3 0 C2H2-type zinc-finger domain RVT_1 PF00078.27 PIK36992.1 - 2.3e-23 82.9 0.2 4.6e-23 81.9 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK36992.1 - 2.6e-22 78.8 0.0 6.8e-22 77.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK36992.1 - 3.9e-17 62.5 0.0 8.9e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Gal-3-0_sulfotr PF06990.11 PIK36993.1 - 6.1e-46 157.1 2.1 8.4e-46 156.6 2.1 1.3 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK36993.1 - 0.00014 21.4 0.0 0.00035 20.1 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK36993.1 - 0.058 13.8 0.1 0.48 10.8 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family SIR2 PF02146.17 PIK36994.1 - 6.2e-51 172.8 0.0 8.6e-51 172.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 PIK36994.1 - 0.14 11.9 0.0 0.42 10.3 0.0 1.8 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Cytomega_TRL10 PF06084.11 PIK36995.1 - 6.6 6.7 8.8 1.2 9.2 3.4 2.4 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein Glyco_transf_10 PF00852.19 PIK36997.1 - 8.4e-47 159.2 0.1 1.2e-46 158.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK36997.1 - 0.037 14.5 0.0 0.077 13.4 0.0 1.6 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal GTP-bdg_M PF16360.5 PIK36998.1 - 0.27 11.9 4.4 0.36 11.5 0.2 2.5 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Mer2 PF09074.10 PIK36998.1 - 0.48 10.2 6.7 0.59 9.9 4.8 1.9 2 0 0 2 2 2 0 Mer2 Endonuc_Holl PF10107.9 PIK36998.1 - 0.75 9.6 6.6 6.8 6.5 0.3 2.4 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase EST1 PF10374.9 PIK36998.1 - 2 9.1 6.8 4.4 7.9 6.5 1.9 1 1 0 1 1 1 0 Telomerase activating protein Est1 DED PF01335.21 PIK37000.1 - 0.00095 19.4 0.2 0.00095 19.4 0.2 2.8 3 0 0 3 3 3 1 Death effector domain zf-B_box PF00643.24 PIK37000.1 - 0.0014 18.7 15.7 0.0016 18.5 10.0 2.6 2 0 0 2 2 2 1 B-box zinc finger UPF0122 PF04297.14 PIK37000.1 - 0.22 11.8 3.4 2.1 8.7 0.9 3.2 2 1 1 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like Exonuc_VII_L PF02601.15 PIK37000.1 - 0.23 11.0 1.7 0.38 10.3 1.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Apolipoprotein PF01442.18 PIK37001.1 - 0.0057 16.5 2.3 0.0091 15.9 2.3 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 PIK37001.1 - 0.018 14.7 2.0 0.027 14.1 2.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-B_box PF00643.24 PIK37001.1 - 0.13 12.4 18.2 0.42 10.8 12.6 2.7 2 0 0 2 2 2 0 B-box zinc finger ApoO PF09769.9 PIK37001.1 - 0.14 12.1 2.0 12 5.8 0.6 2.4 1 1 1 2 2 2 0 Apolipoprotein O Gal_GalNac_35kD PF17337.2 PIK37001.1 - 0.17 11.9 2.8 0.35 10.9 2.8 1.4 1 0 0 1 1 1 0 Galactose-inhibitable lectin 35 kDa subunit UPF0122 PF04297.14 PIK37001.1 - 0.3 11.3 5.4 0.11 12.7 2.0 2.0 1 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like BshC PF10079.9 PIK37001.1 - 0.34 9.6 8.5 0.5 9.0 8.5 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC TMPIT PF07851.13 PIK37001.1 - 0.49 9.6 3.3 0.93 8.7 3.3 1.5 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.16 PIK37001.1 - 3.6 6.4 4.6 5.2 5.9 4.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 PIK37001.1 - 5.2 7.1 8.0 3.5 7.7 4.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) 7tm_3 PF00003.22 PIK37002.1 - 4.2e-12 46.3 10.8 5.5e-12 45.9 10.8 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Spc7 PF08317.11 PIK37002.1 - 0.034 13.0 11.3 0.054 12.4 11.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 PIK37002.1 - 0.043 13.6 1.3 0.072 12.9 1.3 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF1992 PF09350.10 PIK37002.1 - 0.057 13.6 0.1 0.17 12.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) DivIVA PF05103.13 PIK37002.1 - 0.1 12.7 8.2 1.1 9.4 7.8 2.2 1 1 0 1 1 1 0 DivIVA protein Tup_N PF08581.10 PIK37002.1 - 0.11 12.8 7.5 0.07 13.4 4.9 2.0 2 0 0 2 2 2 0 Tup N-terminal V-SNARE PF05008.15 PIK37002.1 - 0.33 11.4 7.4 0.068 13.5 1.6 2.5 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus CorA PF01544.18 PIK37002.1 - 0.57 9.4 2.9 1.3 8.3 0.2 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein ATG16 PF08614.11 PIK37002.1 - 0.77 10.0 16.2 0.025 14.8 7.2 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) RecG_N PF17190.4 PIK37002.1 - 0.98 10.2 5.9 0.48 11.2 3.0 1.9 1 1 1 2 2 2 0 RecG N-terminal helical domain IFT46_B_C PF12317.8 PIK37002.1 - 1.3 8.7 7.4 5.6 6.6 1.2 2.2 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal DUF1664 PF07889.12 PIK37002.1 - 1.4 9.0 4.4 2.8 8.0 4.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 PIK37002.1 - 2.3 8.0 12.6 5.6 6.8 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Wbp11 PF09429.10 PIK37002.1 - 2.5 8.6 13.4 1.4 9.4 2.2 2.5 1 1 1 2 2 2 0 WW domain binding protein 11 Jnk-SapK_ap_N PF09744.9 PIK37002.1 - 3.1 8.0 18.7 5.6 7.2 18.1 1.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3818 PF12825.7 PIK37002.1 - 3.3 6.6 7.1 4.7 6.1 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Cep57_CLD_2 PF14197.6 PIK37002.1 - 4.1 7.6 11.9 5.5 7.2 5.5 3.0 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 GAS PF13851.6 PIK37002.1 - 4.4 6.6 16.1 14 5.0 12.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF148 PF02520.17 PIK37002.1 - 6.3 7.0 9.4 3 8.0 1.7 2.7 2 1 1 3 3 3 0 Domain of unknown function DUF148 ANF_receptor PF01094.28 PIK37003.1 - 1.2e-63 215.4 0.0 1.6e-63 215.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK37003.1 - 1.2e-11 44.9 0.2 1.7e-11 44.4 0.2 1.2 1 0 0 1 1 1 1 Periplasmic binding protein NCD3G PF07562.14 PIK37003.1 - 0.022 14.7 0.4 0.046 13.7 0.4 1.5 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR CTP_transf_3 PF02348.19 PIK37003.1 - 0.028 14.3 0.0 0.34 10.8 0.0 2.5 2 1 1 3 3 3 0 Cytidylyltransferase zf-CCHC PF00098.23 PIK37004.1 - 9.9e-07 28.6 16.2 0.00071 19.5 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37004.1 - 0.001 18.9 8.1 0.11 12.3 3.8 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37004.1 - 0.024 14.5 0.2 0.024 14.5 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37004.1 - 0.024 14.4 0.8 0.024 14.4 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK37004.1 - 0.04 13.9 16.2 0.37 10.8 0.1 3.8 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK37004.1 - 0.041 13.6 11.1 5.3 6.9 0.3 3.5 2 1 1 3 3 3 0 Zinc knuckle SET PF00856.28 PIK37005.1 - 2.4e-08 34.5 0.0 5e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 SET domain PPO1_DWL PF12142.8 PIK37005.1 - 0.0067 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Polyphenol oxidase middle domain Myotoxins PF00819.17 PIK37005.1 - 0.71 10.2 2.5 29 5.0 0.0 2.3 2 0 0 2 2 2 0 Myotoxin, crotamine zf-RVT PF13966.6 PIK37006.1 - 3.1e-06 27.8 2.3 3.1e-06 27.8 2.3 1.9 2 1 0 2 2 2 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK37008.1 - 2.4e-30 105.7 0.0 4.1e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK37008.1 - 8.2e-17 61.1 0.0 1.7e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK37008.1 - 2.5e-15 56.3 1.4 5.9e-15 55.1 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK37008.1 - 5.9e-08 32.9 0.0 1.5e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK37008.1 - 0.00028 21.1 0.0 0.00079 19.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TTC5_OB PF16669.5 PIK37008.1 - 0.12 12.1 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain Spuma_A9PTase PF03539.14 PIK37008.1 - 0.17 12.0 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Pou PF00157.17 PIK37010.1 - 3.8e-38 129.3 0.1 8e-38 128.3 0.1 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK37010.1 - 4.8e-18 64.7 0.8 4.8e-18 64.7 0.8 2.3 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 PIK37010.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain HTH_31 PF13560.6 PIK37010.1 - 0.047 14.1 0.0 0.66 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain ABC_trans_N PF14510.6 PIK37010.1 - 0.09 13.4 0.1 0.8 10.4 0.0 2.4 2 0 0 2 2 2 0 ABC-transporter N-terminal HATPase_c_3 PF13589.6 PIK37011.1 - 0.0053 16.6 0.0 0.35 10.7 0.0 2.2 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FliJ PF02050.16 PIK37012.1 - 0.0098 16.1 1.5 4.2 7.6 1.0 2.3 2 0 0 2 2 2 2 Flagellar FliJ protein Methyltransf_11 PF08241.12 PIK37013.1 - 1.5e-15 57.6 0.0 2.7e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37013.1 - 1.1e-13 51.7 0.0 1.9e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK37013.1 - 7.2e-10 39.0 0.0 9.3e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37013.1 - 4.2e-07 29.9 0.0 6.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK37013.1 - 6.8e-06 26.7 0.0 1.2e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 PIK37013.1 - 4.1e-05 22.3 0.0 5.2e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 PIK37013.1 - 8.6e-05 22.0 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 PIK37013.1 - 0.00072 19.2 0.0 0.0014 18.3 0.0 1.4 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 PIK37013.1 - 0.0023 17.5 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 PIK37013.1 - 0.0038 16.4 0.0 0.005 16.0 0.0 1.3 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_24 PF13578.6 PIK37013.1 - 0.0059 17.6 0.0 0.014 16.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 PIK37013.1 - 0.0064 16.2 0.0 0.0096 15.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_32 PF13679.6 PIK37013.1 - 0.0072 16.3 0.8 0.019 14.9 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain PrmA PF06325.13 PIK37013.1 - 0.027 13.9 0.1 0.047 13.1 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 PIK37013.1 - 0.034 13.7 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 ADH_zinc_N PF00107.26 PIK37013.1 - 0.062 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_18 PF12847.7 PIK37013.1 - 0.076 12.9 0.1 0.14 12.0 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK37014.1 - 6.6e-12 45.9 0.0 1.6e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37014.1 - 7.5e-10 39.4 0.0 2e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37014.1 - 4.2e-05 23.4 0.0 8.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK37014.1 - 0.00024 20.5 0.0 0.00042 19.7 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK37014.1 - 0.0054 17.4 0.0 0.016 15.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 PIK37014.1 - 0.0086 14.7 0.2 0.014 14.0 0.0 1.4 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 PIK37014.1 - 0.085 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Homeodomain PF00046.29 PIK37016.1 - 4.8e-21 74.4 3.2 1e-20 73.3 3.2 1.6 1 0 0 1 1 1 1 Homeodomain MIF PF01187.18 PIK37017.1 - 0.00036 20.8 0.0 0.00045 20.5 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) MIF PF01187.18 PIK37018.1 - 3.5e-08 33.8 0.0 5.5e-08 33.1 0.0 1.3 1 1 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 PIK37018.1 - 0.012 15.5 0.1 2 8.4 0.0 2.4 2 0 0 2 2 2 0 Tautomerase enzyme Molydop_binding PF01568.21 PIK37018.1 - 0.037 14.0 0.0 0.084 12.9 0.0 1.6 2 0 0 2 2 2 0 Molydopterin dinucleotide binding domain MFS_1 PF07690.16 PIK37019.1 - 3.2e-16 59.2 18.1 1.8e-12 46.9 7.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK37019.1 - 7e-12 44.9 21.0 7e-09 35.1 7.8 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 PIK37019.1 - 0.00028 20.3 5.8 0.00028 20.3 5.8 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF2070 PF09843.9 PIK37019.1 - 0.038 12.3 13.4 0.11 10.8 0.7 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) ANF_receptor PF01094.28 PIK37020.1 - 5.9e-38 130.9 0.1 7e-38 130.6 0.1 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Gal-3-0_sulfotr PF06990.11 PIK37021.1 - 6.5e-48 163.6 1.1 8.7e-48 163.2 1.1 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK37021.1 - 0.0021 17.6 0.1 0.0043 16.6 0.1 1.6 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK37021.1 - 0.0026 18.2 0.2 0.0063 16.9 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family FERM_N PF09379.10 PIK37021.1 - 0.13 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 FERM N-terminal domain Pur_ac_phosph_N PF16656.5 PIK37022.1 - 0.086 13.4 0.7 0.16 12.6 0.1 1.7 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Synaphin PF05835.12 PIK37022.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.1 2 1 1 3 3 3 0 Synaphin protein EGF PF00008.27 PIK37023.1 - 4.1e-18 65.4 69.6 4.1e-05 23.8 7.1 6.1 6 0 0 6 6 6 5 EGF-like domain HYR PF02494.16 PIK37023.1 - 3.8e-09 36.8 2.3 8.3e-07 29.3 1.2 2.7 2 0 0 2 2 2 2 HYR domain SEA PF01390.20 PIK37023.1 - 6.9e-07 29.3 0.4 1.4e-06 28.3 0.4 1.5 1 0 0 1 1 1 1 SEA domain EGF_2 PF07974.13 PIK37023.1 - 2.5e-05 24.5 85.2 0.018 15.4 9.0 5.8 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 PIK37023.1 - 0.0014 19.2 77.2 0.015 15.9 8.1 7.1 7 0 0 7 7 7 4 Human growth factor-like EGF DUF1735 PF08522.10 PIK37023.1 - 0.03 14.9 0.8 0.17 12.5 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1735) OAS1_C PF10421.9 PIK37024.1 - 1.3e-09 37.8 0.0 2.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NTP_transf_2 PF01909.23 PIK37024.1 - 0.00011 22.4 0.0 0.00029 21.1 0.0 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain LRR_8 PF13855.6 PIK37025.1 - 5e-17 61.4 26.4 3.8e-07 29.8 6.0 3.9 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK37025.1 - 1.8e-12 47.3 29.4 0.00012 22.3 1.6 6.1 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) Peptidase_C14 PF00656.22 PIK37025.1 - 1.8e-12 47.7 0.0 3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Caspase domain LRR_9 PF14580.6 PIK37025.1 - 0.022 14.3 8.4 0.52 9.8 0.1 3.3 1 1 0 2 2 2 0 Leucine-rich repeat CtsR PF05848.11 PIK37025.1 - 0.034 14.1 0.1 1.2 9.1 0.0 2.7 3 0 0 3 3 3 0 CtsR N-terminal HTH domain LRR_1 PF00560.33 PIK37025.1 - 1 10.2 33.0 3.4 8.6 0.6 9.2 7 3 1 8 8 8 0 Leucine Rich Repeat DUF4200 PF13863.6 PIK37026.1 - 3.1e-36 124.4 16.0 3.1e-36 124.4 16.0 4.8 3 1 0 4 4 4 1 Domain of unknown function (DUF4200) Amidohydro_3 PF07969.11 PIK37027.1 - 8.5e-20 71.7 1.6 3.5e-13 49.8 0.1 2.3 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 PIK37027.1 - 7.1e-17 61.7 0.9 2.4e-12 46.8 0.3 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 PIK37027.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Adenosine/AMP deaminase LSM PF01423.22 PIK37028.1 - 2.8e-21 75.0 0.0 3.3e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 PIK37028.1 - 0.06 13.5 0.0 0.066 13.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM PF01423.22 PIK37029.1 - 3.1e-13 49.2 0.3 4.1e-13 48.8 0.3 1.2 1 0 0 1 1 1 1 LSM domain C2 PF00168.30 PIK37030.1 - 1.4e-36 124.8 0.0 3.8e-18 65.7 0.0 2.3 2 0 0 2 2 2 2 C2 domain DUF3340 PF11818.8 PIK37030.1 - 0.044 14.0 1.0 0.079 13.1 1.0 1.3 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) DivIC PF04977.15 PIK37030.1 - 0.05 13.4 0.3 0.098 12.4 0.3 1.4 1 0 0 1 1 1 0 Septum formation initiator MFS_1 PF07690.16 PIK37031.1 - 4.3e-06 25.9 29.7 2.8e-05 23.2 8.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-H2C2_2 PF13465.6 PIK37033.1 - 9.5e-103 332.5 126.7 7e-09 35.7 3.9 16.4 16 0 0 16 16 16 15 Zinc-finger double domain zf-C2H2 PF00096.26 PIK37033.1 - 1.1e-50 167.3 140.4 3.1e-05 24.2 2.5 16.5 17 0 0 17 17 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK37033.1 - 1e-40 134.9 127.2 0.0014 19.3 1.2 16.7 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK37033.1 - 3.6e-17 62.2 81.9 0.0047 17.2 0.2 16.0 16 1 1 17 17 17 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK37033.1 - 1.4e-06 28.5 86.6 0.0089 16.4 0.3 14.4 15 0 0 15 15 14 5 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK37033.1 - 6.8e-06 25.7 5.0 0.0005 19.8 0.4 18.0 16 8 0 16 16 13 5 C2H2-type zinc-finger domain GAGA PF09237.11 PIK37033.1 - 4.1e-05 23.3 29.1 2.3 8.1 0.1 8.4 5 2 2 8 8 8 3 GAGA factor PyrI_C PF02748.15 PIK37033.1 - 0.00019 21.3 64.0 0.29 11.1 0.4 13.5 13 2 2 15 15 15 4 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_4 PF07975.12 PIK37033.1 - 0.00029 21.0 68.9 0.029 14.6 4.5 10.3 3 3 7 11 11 11 4 TFIIH C1-like domain zf-C2H2_6 PF13912.6 PIK37033.1 - 0.001 19.0 0.5 0.001 19.0 0.5 15.5 15 1 0 15 15 15 5 C2H2-type zinc finger zf-AN1 PF01428.16 PIK37033.1 - 0.0022 18.1 76.6 5.5 7.2 0.1 14.9 13 1 2 15 15 15 1 AN1-like Zinc finger zinc_ribbon_15 PF17032.5 PIK37033.1 - 0.003 18.3 52.2 2.2 9.1 1.7 8.4 5 3 4 9 9 9 4 zinc-ribbon family zf-C2HE PF16278.5 PIK37033.1 - 0.016 15.6 77.7 0.11 12.9 0.5 12.0 2 1 9 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger Sprouty PF05210.13 PIK37033.1 - 0.026 14.9 1.8 0.026 14.9 1.8 6.6 6 2 1 7 7 5 0 Sprouty protein (Spry) zf-C2H2_11 PF16622.5 PIK37033.1 - 0.056 13.2 66.8 0.09 12.6 0.0 12.9 15 0 0 15 15 15 0 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 PIK37033.1 - 0.09 13.5 46.4 2.6 8.8 0.4 9.4 2 2 5 8 8 8 0 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 PIK37033.1 - 0.13 12.5 23.9 4.9 7.5 0.0 7.3 5 2 1 8 8 8 0 BolA-like protein Peptidase_A17 PF05380.13 PIK37034.1 - 1.2e-57 194.4 0.0 3e-57 193.2 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase gag-asp_proteas PF13975.6 PIK37034.1 - 2e-07 31.5 0.2 8.4e-07 29.5 0.1 2.3 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK37034.1 - 1.8e-06 28.5 0.1 6.2e-06 26.8 0.1 2.0 1 0 0 1 1 1 1 Aspartyl protease RVT_1 PF00078.27 PIK37034.1 - 9.1e-05 22.1 0.0 0.00026 20.6 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK37034.1 - 0.0002 21.3 0.0 0.00073 19.5 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37034.1 - 0.0005 20.3 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Acyl_transf_3 PF01757.22 PIK37035.1 - 4.3e-09 35.9 25.6 4.3e-09 35.9 25.6 2.0 2 1 0 2 2 2 1 Acyltransferase family DUF2232 PF09991.9 PIK37035.1 - 0.0058 15.9 0.5 0.018 14.2 0.5 1.8 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) MutS_V PF00488.21 PIK37036.1 - 3.8e-63 212.9 0.0 4.5e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 MutS domain V ANAPC16 PF17256.2 PIK37036.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 MutS_III PF05192.18 PIK37037.1 - 8.1e-37 127.3 0.3 1.6e-36 126.4 0.3 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 PIK37037.1 - 2.3e-35 121.3 0.1 6.4e-35 119.8 0.1 1.8 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 PIK37037.1 - 9.2e-17 61.2 0.8 6.6e-16 58.4 0.1 2.4 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 PIK37037.1 - 1.6e-10 41.4 0.0 3.8e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 MutS domain II MSC PF09402.10 PIK37037.1 - 0.0043 16.6 0.1 0.18 11.3 0.1 2.2 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain PWWP PF00855.17 PIK37038.1 - 8.6e-09 35.7 0.2 8.6e-09 35.7 0.2 1.8 2 1 0 2 2 2 1 PWWP domain DUF4796 PF16044.5 PIK37039.1 - 3.2e-46 157.3 6.6 4.1e-30 104.8 1.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4796) Ureidogly_lyase PF04115.12 PIK37039.1 - 0.00097 18.9 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Ureidoglycolate lyase zf-C2HC5 PF06221.13 PIK37039.1 - 0.068 13.2 0.9 0.16 12.0 0.9 1.5 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Ank_2 PF12796.7 PIK37040.1 - 7.9e-18 64.8 0.9 7.9e-18 64.8 0.9 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK37040.1 - 1.9e-15 56.5 1.9 1.5e-06 28.3 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK37040.1 - 2.3e-15 56.4 2.3 1.5e-08 34.7 0.4 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK37040.1 - 2.4e-15 56.7 1.3 5.3e-08 33.2 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK37040.1 - 5.5e-15 54.0 0.3 2.2e-06 27.5 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Transcrip_reg PF01709.20 PIK37040.1 - 0.017 14.6 0.2 0.1 12.0 0.0 1.9 1 1 1 2 2 2 0 Transcriptional regulator Arg_repressor PF01316.21 PIK37040.1 - 0.084 12.6 0.3 2.1 8.2 0.1 2.2 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain RPE65 PF03055.15 PIK37041.1 - 1.7e-111 373.7 0.4 1.9e-111 373.5 0.4 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Transposase_24 PF03004.14 PIK37042.1 - 1.5e-07 31.6 0.0 2.1e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Plant transposase (Ptta/En/Spm family) 7tm_1 PF00001.21 PIK37043.1 - 2.3e-19 69.8 3.5 2.9e-19 69.4 3.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Presenilin PF01080.17 PIK37043.1 - 0.15 10.8 3.3 0.17 10.6 3.3 1.1 1 0 0 1 1 1 0 Presenilin 7tm_1 PF00001.21 PIK37044.1 - 1e-10 41.4 0.1 1.2e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4834 PF16118.5 PIK37044.1 - 0.017 16.1 0.1 0.017 16.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Shisa PF13908.6 PIK37044.1 - 0.02 15.2 0.5 0.13 12.5 0.1 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Piezo_RRas_bdg PF12166.8 PIK37044.1 - 0.15 11.3 1.2 1.1 8.4 0.2 2.0 1 1 1 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain HemY_N PF07219.13 PIK37044.1 - 0.22 11.7 5.4 1.4 9.1 0.0 2.2 2 0 0 2 2 2 0 HemY protein N-terminus DUF1980 PF09323.10 PIK37044.1 - 0.84 9.5 3.2 0.39 10.6 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Orf78 PF06024.12 PIK37044.1 - 6.8 7.1 6.1 11 6.4 2.8 2.4 1 1 1 2 2 2 0 Orf78 (ac78) MACPF PF01823.19 PIK37045.1 - 9.3e-11 42.2 0.1 1.2e-10 41.9 0.1 1.3 1 1 0 1 1 1 1 MAC/Perforin domain Sulfotransfer_1 PF00685.27 PIK37046.1 - 8.2e-12 45.2 0.0 1.1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK37046.1 - 1.5e-06 28.8 0.1 0.0011 19.4 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK37046.1 - 0.037 13.9 2.5 0.095 12.6 2.5 1.8 1 1 0 1 1 1 0 Sulfotransferase family SH2 PF00017.24 PIK37047.1 - 1.4e-13 50.8 0.1 3.4e-13 49.5 0.1 1.7 1 0 0 1 1 1 1 SH2 domain Death PF00531.22 PIK37047.1 - 2.2e-08 34.1 0.1 3.8e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Death domain SH2_2 PF14633.6 PIK37047.1 - 0.04 13.3 0.1 0.21 10.9 0.1 2.0 1 1 1 2 2 2 0 SH2 domain Rep_3 PF01051.21 PIK37048.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Initiator Replication protein Transposase_21 PF02992.14 PIK37049.1 - 0.053 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Transposase family tnp2 Glyco_transf_10 PF00852.19 PIK37050.1 - 1.9e-46 158.0 1.3 3e-46 157.4 1.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK37050.1 - 8.7e-08 32.6 0.0 1.9e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DUF3343 PF11823.8 PIK37050.1 - 0.012 15.1 0.0 0.73 9.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) Glyco_transf_10 PF00852.19 PIK37051.1 - 1.3e-07 31.5 0.0 2.3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK37051.1 - 3.3e-06 27.5 0.2 2e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Atthog PF18800.1 PIK37052.1 - 1.9e-54 183.4 6.4 2.7e-54 182.9 6.4 1.2 1 0 0 1 1 1 1 Attenuator of Hedgehog L_HMGIC_fpl PF10242.9 PIK37052.1 - 1.1e-05 25.7 8.8 1.6e-05 25.2 8.7 1.5 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein LT-IIB PF06453.11 PIK37052.1 - 0.0086 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Type II heat-labile enterotoxin , B subunit (LT-IIB) DUF2070 PF09843.9 PIK37052.1 - 0.087 11.1 9.0 0.12 10.6 9.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4220 PF13968.6 PIK37052.1 - 0.11 11.9 2.5 0.61 9.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4220) CCB1 PF12046.8 PIK37052.1 - 0.11 11.9 0.8 0.23 10.8 0.8 1.6 1 1 0 1 1 1 0 Cofactor assembly of complex C subunit B Clc-like PF07062.12 PIK37052.1 - 0.44 10.0 0.1 0.44 10.0 0.1 2.6 2 1 0 2 2 2 0 Clc-like DUF2975 PF11188.8 PIK37052.1 - 0.63 9.9 13.4 0.07 13.0 8.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) Claudin_3 PF06653.11 PIK37052.1 - 2.2 8.2 15.0 7.4 6.5 15.0 2.0 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF410 PF04190.13 PIK37053.1 - 8.6e-71 238.7 0.0 1.1e-70 238.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Vps39_1 PF10366.9 PIK37053.1 - 0.25 11.7 1.3 0.55 10.5 0.5 1.9 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Cyt-b5 PF00173.28 PIK37054.1 - 7.1e-10 38.9 0.1 1.3e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Med15 PF09606.10 PIK37055.1 - 1.6e-52 179.3 109.2 5.9e-46 157.6 102.4 3.5 1 1 1 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal KIX PF02172.16 PIK37055.1 - 0.023 15.0 0.1 0.07 13.4 0.1 1.8 1 0 0 1 1 1 0 KIX domain DNA_pol_phi PF04931.13 PIK37056.1 - 1.4e-39 135.9 0.1 1.9e-39 135.5 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase phi DNA_pol_phi PF04931.13 PIK37057.1 - 6.1e-121 404.9 16.3 7.4e-121 404.6 16.3 1.1 1 0 0 1 1 1 1 DNA polymerase phi DUF5095 PF17016.5 PIK37057.1 - 0.031 14.0 0.2 0.062 13.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) TAN PF11640.8 PIK37057.1 - 0.078 13.1 4.1 0.092 12.9 0.1 3.1 4 0 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Ig_2 PF13895.6 PIK37058.1 - 1.7e-05 25.1 1.5 0.00076 19.8 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK37058.1 - 0.00014 22.4 2.9 0.014 16.0 0.1 3.5 3 0 0 3 3 3 1 Immunoglobulin domain hEGF PF12661.7 PIK37058.1 - 0.00014 22.3 7.2 0.00014 22.3 7.2 5.6 5 1 1 6 6 6 1 Human growth factor-like EGF Izumo-Ig PF16706.5 PIK37058.1 - 0.017 15.2 0.0 0.092 12.8 0.0 2.1 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain I-set PF07679.16 PIK37058.1 - 0.023 14.7 0.1 0.1 12.7 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 PIK37058.1 - 0.047 13.9 0.0 0.24 11.6 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin V-set domain Laminin_EGF PF00053.24 PIK37058.1 - 2 8.6 50.3 1.6 9.0 20.5 4.0 1 1 2 3 3 3 0 Laminin EGF domain Y_phosphatase PF00102.27 PIK37059.1 - 3.2e-39 134.9 0.0 7e-23 81.4 0.0 2.5 1 1 1 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK37059.1 - 5.8e-12 45.8 5.6 8.4e-07 29.3 0.1 3.8 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK37059.1 - 0.0012 19.3 5.5 0.23 12.1 0.0 3.5 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DSPc PF00782.20 PIK37059.1 - 0.03 14.1 1.0 0.13 12.1 0.1 2.4 2 1 1 3 3 3 0 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 PIK37060.1 - 1.7e-32 111.0 44.6 2e-12 46.7 6.4 5.9 3 2 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 PIK37060.1 - 1.3e-15 57.3 29.6 0.00036 20.9 3.1 6.7 6 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37060.1 - 2.3e-10 40.5 3.5 0.00022 21.2 0.1 2.2 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK37060.1 - 5.1e-08 32.4 15.8 3 8.7 0.0 8.4 8 0 0 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK37060.1 - 4e-06 26.5 8.6 0.0001 21.9 0.9 3.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 PIK37060.1 - 0.0034 17.3 20.5 1.9 8.8 0.4 7.4 7 0 0 7 7 7 3 Leucine Rich repeat LRR_8 PF13855.6 PIK37061.1 - 8e-32 108.8 17.9 1.5e-13 50.2 7.1 4.7 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK37061.1 - 8.8e-12 45.1 28.8 9.4e-05 22.7 1.3 5.6 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37061.1 - 1.4e-08 34.8 2.3 6.8e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37061.1 - 3.7e-07 29.8 3.8 7.9e-06 25.5 0.1 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 PIK37061.1 - 0.27 11.9 23.9 51 5.0 0.5 7.4 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK37061.1 - 0.54 10.4 24.6 1.5 9.1 0.4 7.2 7 0 0 7 7 7 0 Leucine Rich repeat LRR_8 PF13855.6 PIK37062.1 - 1.7e-28 98.1 22.8 3.6e-12 45.9 6.5 4.4 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK37062.1 - 7.5e-13 48.4 26.7 7.7e-05 23.0 0.7 5.3 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37062.1 - 4.4e-08 33.1 2.5 7.1e-05 22.8 0.0 2.5 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37062.1 - 2.5e-07 30.4 4.9 1.3e-05 24.8 0.4 3.2 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 PIK37062.1 - 0.73 10.6 24.3 15 6.6 0.0 7.1 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK37062.1 - 6.9 7.0 27.8 5.7 7.3 0.3 7.5 8 0 0 8 8 8 0 Leucine Rich repeat NACHT PF05729.12 PIK37063.1 - 3.9e-07 30.1 0.0 8.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain GPI2 PF06432.11 PIK37063.1 - 0.06 12.8 0.0 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase RNA_pol_Rpb2_3 PF04565.16 PIK37063.1 - 0.18 12.0 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 3 YabP PF07873.11 PIK37064.1 - 0.046 13.5 0.4 0.86 9.4 0.1 2.6 2 0 0 2 2 2 0 YabP family Nucleoporin_N PF08801.11 PIK37064.1 - 0.081 11.7 0.4 8.3 5.0 0.1 2.2 1 1 0 2 2 2 0 Nup133 N terminal like zf-CCHC PF00098.23 PIK37066.1 - 1.1e-06 28.4 16.2 0.0007 19.6 0.2 3.8 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37066.1 - 0.00059 19.6 7.7 0.11 12.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37066.1 - 0.024 14.5 0.2 0.024 14.5 0.2 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37066.1 - 0.024 14.4 0.8 0.024 14.4 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK37066.1 - 0.044 13.5 11.3 5.4 6.8 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK37066.1 - 0.12 12.3 17.7 0.26 11.3 1.2 3.9 3 1 2 5 5 5 0 Zinc knuckle zf-RING_UBOX PF13445.6 PIK37067.1 - 7.1e-10 38.8 7.3 7.1e-10 38.8 7.3 2.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK37067.1 - 1.3e-09 37.8 10.5 1.3e-09 37.8 10.5 3.9 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK37067.1 - 7.4e-09 35.3 7.3 7.4e-09 35.3 7.3 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK37067.1 - 1.5e-07 31.6 9.0 1.5e-07 31.6 9.0 3.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK37067.1 - 2.7e-07 30.3 11.0 2.7e-07 30.3 11.0 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK37067.1 - 5.5e-07 29.6 9.5 5.5e-07 29.6 9.5 3.9 3 2 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK37067.1 - 3.6e-05 23.6 9.2 3.6e-05 23.6 9.2 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK37067.1 - 4.7e-05 23.5 29.4 0.00042 20.4 13.8 4.4 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK37067.1 - 0.0006 19.6 7.6 0.0006 19.6 7.6 3.8 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 PCRF PF03462.18 PIK37067.1 - 0.039 13.8 0.4 0.039 13.8 0.4 2.6 2 1 1 3 3 3 0 PCRF domain Ribosomal_L17 PF01196.19 PIK37067.1 - 0.45 11.4 5.1 0.29 12.0 2.5 2.0 2 0 0 2 2 1 0 Ribosomal protein L17 zinc-ribbons_6 PF07191.12 PIK37067.1 - 1.1 9.3 35.2 0.15 12.1 1.8 4.3 3 2 0 4 4 4 0 zinc-ribbons DUF4407 PF14362.6 PIK37067.1 - 1.7 7.9 10.6 2.5 7.4 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.27 PIK37069.1 - 0.0024 17.4 0.0 0.0049 16.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2095 PF09868.9 PIK37071.1 - 0.042 13.8 0.0 0.076 13.0 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) EGF PF00008.27 PIK37072.1 - 1.6e-13 50.7 57.7 9.1e-09 35.5 12.9 4.7 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 PIK37072.1 - 1.2e-05 25.7 8.7 1.2e-05 25.7 8.7 5.5 6 0 0 6 6 5 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK37072.1 - 7.2e-05 23.1 52.9 0.0003 21.1 12.7 4.1 4 0 0 4 4 4 2 EGF-like domain EphA2_TM PF14575.6 PIK37072.1 - 0.0079 17.0 0.0 0.017 16.0 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK37072.1 - 0.012 15.5 0.0 0.061 13.2 0.0 2.1 3 0 0 3 3 3 0 TMEM154 protein family Stevor PF17410.2 PIK37072.1 - 0.032 13.8 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Baculo_11_kDa PF06143.11 PIK37072.1 - 0.059 13.0 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Adeno_E3_CR2 PF02439.15 PIK37072.1 - 0.085 12.6 3.4 0.17 11.6 3.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 RCR PF12273.8 PIK37072.1 - 0.11 13.1 4.8 0.51 11.0 4.8 2.1 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red ECSCR PF15820.5 PIK37072.1 - 0.18 11.6 0.2 0.91 9.4 0.0 2.0 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator CcmD PF04995.14 PIK37072.1 - 0.51 10.5 5.6 0.79 9.9 5.6 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Syndecan PF01034.20 PIK37072.1 - 0.59 10.1 3.3 1.1 9.2 3.3 1.3 1 0 0 1 1 1 0 Syndecan domain Cadherin PF00028.17 PIK37073.1 - 3.5e-53 178.0 4.1 3.8e-20 72.1 0.0 5.4 5 0 0 5 5 5 4 Cadherin domain Laminin_G_2 PF02210.24 PIK37073.1 - 1.7e-20 73.9 0.0 5.2e-20 72.3 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK37073.1 - 1.6e-17 64.0 0.0 4.7e-17 62.4 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 PIK37073.1 - 2.4e-07 31.0 0.8 8.7e-07 29.2 0.3 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Cadherin_3 PF16184.5 PIK37073.1 - 9.3e-06 25.6 5.3 0.00095 19.2 0.1 4.7 4 1 1 5 5 5 1 Cadherin-like EGF PF00008.27 PIK37073.1 - 0.0041 17.4 6.5 0.0041 17.4 6.5 2.9 3 0 0 3 3 3 1 EGF-like domain PCC_BT PF18140.1 PIK37073.1 - 0.01 16.2 0.1 0.36 11.2 0.0 3.2 4 0 0 4 4 4 0 Propionyl-coenzyme A carboxylase BT domain Cadherin_2 PF08266.12 PIK37073.1 - 0.066 13.1 0.2 11 6.0 0.1 3.5 3 0 0 3 3 3 0 Cadherin-like He_PIG PF05345.12 PIK37073.1 - 0.14 12.4 3.1 37 4.6 0.0 4.5 5 0 0 5 5 5 0 Putative Ig domain IL4Ra_N PF09238.10 PIK37073.1 - 1.1 9.6 3.5 5.5 7.4 0.5 2.4 1 1 1 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal Cadherin PF00028.17 PIK37074.1 - 2.5e-146 476.6 25.5 7.7e-18 64.7 0.0 12.4 12 0 0 12 12 12 12 Cadherin domain Cadherin_2 PF08266.12 PIK37074.1 - 7.5e-11 41.7 0.2 0.58 10.0 0.0 8.6 9 0 0 9 9 9 2 Cadherin-like RET_CLD1 PF17756.1 PIK37074.1 - 2.6e-06 27.7 1.4 0.86 9.9 0.0 6.5 7 2 1 8 8 8 2 RET Cadherin like domain 1 Cadherin_pro PF08758.11 PIK37074.1 - 0.00028 21.0 0.4 15 5.8 0.0 6.5 8 0 0 8 8 8 1 Cadherin prodomain like Cadherin PF00028.17 PIK37075.1 - 2.7e-53 178.4 2.6 4.5e-16 59.1 0.1 6.1 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.12 PIK37075.1 - 0.00012 21.9 0.1 0.33 10.8 0.0 3.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_pro PF08758.11 PIK37075.1 - 0.00021 21.4 0.2 0.00098 19.2 0.1 2.2 2 0 0 2 2 2 1 Cadherin prodomain like PepSY PF03413.19 PIK37075.1 - 0.00031 21.3 3.3 5.2 7.7 0.0 4.1 5 0 0 5 5 5 2 Peptidase propeptide and YPEB domain Cadherin PF00028.17 PIK37076.1 - 2.2e-16 60.0 0.5 7.8e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Cadherin domain Cadherin PF00028.17 PIK37077.1 - 5.8e-94 308.7 6.8 2.6e-18 66.3 0.0 8.5 9 0 0 9 9 9 8 Cadherin domain Cadherin_3 PF16184.5 PIK37077.1 - 5.8e-09 35.9 2.6 0.013 15.5 0.0 5.5 5 1 0 5 5 5 4 Cadherin-like Cadherin_2 PF08266.12 PIK37077.1 - 0.0088 15.9 0.1 5.6 6.9 0.0 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_4 PF17803.1 PIK37077.1 - 0.094 13.4 13.8 11 6.8 0.1 6.0 7 0 0 7 7 7 0 Bacterial cadherin-like domain Hormone_recep PF00104.30 PIK37079.1 - 1.6e-25 89.9 1.9 1.6e-25 89.9 1.9 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 PIK37079.1 - 0.00077 19.9 3.9 0.00077 19.9 3.9 2.3 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) UDPGT PF00201.18 PIK37080.1 - 7.9e-50 170.1 0.0 8.9e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Guanylate_cyc PF00211.20 PIK37080.1 - 0.17 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain PKD PF00801.20 PIK37081.1 - 0.11 12.4 0.0 0.39 10.6 0.0 1.9 1 1 0 1 1 1 0 PKD domain SNF PF00209.18 PIK37082.1 - 5.1e-182 606.2 38.5 4.1e-123 411.8 21.7 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family cNMP_binding PF00027.29 PIK37083.1 - 3.4e-48 161.7 0.1 1.1e-15 57.4 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.22 PIK37083.1 - 2.4e-13 50.7 0.0 8.8e-13 48.9 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Collectrin PF16959.5 PIK37083.1 - 0.0046 16.7 0.1 0.012 15.4 0.1 1.6 1 0 0 1 1 1 1 Renal amino acid transporter TMEM154 PF15102.6 PIK37083.1 - 0.064 13.2 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family Patatin PF01734.22 PIK37084.1 - 0.21 11.7 0.0 0.32 11.2 0.0 1.2 1 0 0 1 1 1 0 Patatin-like phospholipase Ank_2 PF12796.7 PIK37085.1 - 0.0034 17.9 0.0 0.0059 17.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Rx_N PF18052.1 PIK37085.1 - 0.0071 16.6 0.4 0.78 10.0 0.0 2.2 2 0 0 2 2 2 1 Rx N-terminal domain Ank_3 PF13606.6 PIK37085.1 - 0.01 16.3 0.0 0.032 14.8 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat Spem1 PF15670.5 PIK37085.1 - 0.042 13.4 0.1 0.055 13.0 0.1 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 Ank_4 PF13637.6 PIK37085.1 - 0.064 13.9 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK37085.1 - 0.14 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ion_trans PF00520.31 PIK37086.1 - 4.3e-14 52.3 10.3 5.9e-14 51.9 10.3 1.2 1 0 0 1 1 1 1 Ion transport protein YWFCY PF14293.6 PIK37086.1 - 0.02 15.2 0.2 0.51 10.7 0.1 2.7 2 0 0 2 2 2 0 YWFCY protein Ada3 PF10198.9 PIK37086.1 - 0.036 14.2 1.0 0.072 13.2 0.0 1.9 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 Takusan PF04822.13 PIK37086.1 - 0.21 11.5 2.7 0.7 9.8 0.1 2.5 2 0 0 2 2 2 0 Takusan VDE PF07137.11 PIK37087.1 - 0.00025 20.7 9.9 0.00029 20.4 9.9 1.1 1 0 0 1 1 1 1 VDE lipocalin domain Y_phosphatase PF00102.27 PIK37088.1 - 3.8e-115 383.4 0.1 2.9e-62 210.3 0.1 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK37088.1 - 8.6e-06 25.6 0.1 0.012 15.4 0.0 2.8 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK37088.1 - 0.01 15.9 0.2 0.23 11.6 0.0 2.9 3 1 0 3 3 3 0 Inositol hexakisphosphate Phage_glycop_gL PF11108.8 PIK37088.1 - 0.019 15.0 0.0 6.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Viral glycoprotein L Y_phosphatase3 PF13350.6 PIK37088.1 - 0.084 12.8 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family MULE PF10551.9 PIK37089.1 - 3.1e-15 56.4 0.0 4.6e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 PIK37089.1 - 0.019 13.9 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 Transposase, Mutator family 7tm_2 PF00002.24 PIK37090.1 - 2.4e-21 76.2 2.7 2.9e-21 75.9 2.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Pkinase PF00069.25 PIK37091.1 - 8.8e-72 241.6 0.0 1.6e-71 240.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37091.1 - 1.2e-41 142.7 0.0 3.5e-41 141.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.18 PIK37091.1 - 4e-38 129.4 1.2 2.2e-20 72.6 0.1 2.5 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_fungal PF17667.1 PIK37091.1 - 1.1e-05 24.4 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK37091.1 - 4.1e-05 23.0 0.0 0.00013 21.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK37091.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SPICE PF15678.5 PIK37092.1 - 2e-50 172.3 22.1 7.1e-48 164.0 22.1 2.2 1 1 0 1 1 1 1 Centriole duplication and mitotic chromosome congression Wtap PF17098.5 PIK37092.1 - 0.08 12.9 7.2 0.045 13.7 4.5 2.1 2 0 0 2 2 2 0 WTAP/Mum2p family QVR PF17064.5 PIK37093.1 - 1 9.6 4.7 0.66 10.3 0.2 2.4 2 0 0 2 2 2 0 Sleepless protein ZU5 PF00791.20 PIK37094.1 - 7.3e-06 26.2 0.0 3.4e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 ZU5 domain NACHT PF05729.12 PIK37095.1 - 6.8e-05 22.9 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK37096.1 - 2.5e-07 30.9 0.3 0.0029 17.9 0.2 2.2 2 0 0 2 2 2 2 Death effector domain Dict-STAT-coil PF09267.10 PIK37096.1 - 0.021 15.2 0.8 0.56 10.6 0.4 2.4 1 1 1 2 2 2 0 Dictyostelium STAT, coiled coil Calcyon PF06387.11 PIK37096.1 - 0.098 12.6 0.2 0.3 11.0 0.1 1.7 1 1 1 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) NACHT PF05729.12 PIK37097.1 - 1e-10 41.8 0.0 1.8e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK37097.1 - 0.0005 19.7 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK37097.1 - 0.018 15.3 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK37097.1 - 0.095 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 PIK37097.1 - 0.16 12.4 0.2 1.4 9.3 0.0 2.7 5 0 0 5 5 5 0 RNA helicase NOP5NT PF08156.13 PIK37097.1 - 0.21 12.0 1.7 0.85 10.1 0.0 2.6 3 0 0 3 3 3 0 NOP5NT (NUC127) domain Mating_N PF12731.7 PIK37098.1 - 0.016 15.3 0.1 0.099 12.7 0.0 2.2 2 0 0 2 2 2 0 Mating-type protein beta 1 RVT_1 PF00078.27 PIK37099.1 - 1.8e-06 27.7 0.0 2.9e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mating_N PF12731.7 PIK37100.1 - 0.019 15.0 0.1 0.11 12.6 0.0 2.1 2 0 0 2 2 2 0 Mating-type protein beta 1 UPF0449 PF15136.6 PIK37100.1 - 0.066 13.7 2.3 0.23 11.9 0.3 2.4 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 CH PF00307.31 PIK37101.1 - 2.5e-22 79.1 0.0 4.5e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK37101.1 - 1.5e-13 50.4 0.0 3.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.22 PIK37101.1 - 9.2e-05 22.6 5.6 0.00019 21.6 5.6 1.5 1 0 0 1 1 1 1 LIM domain CH_2 PF06294.11 PIK37101.1 - 0.017 15.2 0.1 0.063 13.4 0.0 2.0 2 0 0 2 2 2 0 CH-like domain in sperm protein HLH PF00010.26 PIK37102.1 - 1.6e-11 44.0 0.0 4.1e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF515 PF04415.12 PIK37102.1 - 3.3 6.0 9.4 5.1 5.4 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) EF1_GNE PF00736.19 PIK37103.1 - 2.4e-29 101.3 3.0 2.4e-29 101.3 3.0 3.0 4 0 0 4 4 4 1 EF-1 guanine nucleotide exchange domain Cwf_Cwc_15 PF04889.12 PIK37103.1 - 0.00037 20.3 19.0 0.00097 18.9 19.0 1.5 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein RsgA_GTPase PF03193.16 PIK37103.1 - 0.0063 16.4 2.8 0.02 14.8 0.3 2.1 2 0 0 2 2 2 1 RsgA GTPase Sorting_nexin PF03700.13 PIK37103.1 - 0.0099 16.4 2.9 0.0099 16.4 2.9 1.7 2 0 0 2 2 2 1 Sorting nexin, N-terminal domain HAS-barrel PF09378.10 PIK37103.1 - 0.035 14.2 1.2 7.2 6.8 0.2 2.6 2 0 0 2 2 2 0 HAS barrel domain NPIP PF06409.11 PIK37103.1 - 0.047 12.7 8.7 0.73 8.8 1.5 2.3 2 0 0 2 2 2 0 Nuclear pore complex interacting protein (NPIP) YL1 PF05764.13 PIK37103.1 - 0.15 12.1 20.7 0.17 12.0 11.1 2.2 2 0 0 2 2 2 0 YL1 nuclear protein LMBR1 PF04791.16 PIK37103.1 - 0.27 10.1 1.9 0.36 9.7 1.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Rootletin PF15035.6 PIK37103.1 - 0.77 9.8 10.0 0.14 12.2 2.6 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Wtap PF17098.5 PIK37103.1 - 1 9.3 10.5 0.29 11.1 3.9 2.7 3 1 0 3 3 3 0 WTAP/Mum2p family DPM3 PF08285.11 PIK37103.1 - 2.5 8.4 7.4 15 5.9 2.0 2.4 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF4407 PF14362.6 PIK37103.1 - 4.6 6.5 10.7 9.9 5.4 10.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) WD40_alt PF14077.6 PIK37103.1 - 5.5 6.9 7.2 0.48 10.3 0.2 2.8 3 1 0 3 3 3 0 Alternative WD40 repeat motif H-kinase_dim PF02895.14 PIK37103.1 - 9.7 6.7 7.5 3.3 8.2 2.2 2.9 3 2 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain LSM PF01423.22 PIK37104.1 - 1e-13 50.7 0.9 1.2e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 LSM domain CbiG_mid PF11761.8 PIK37105.1 - 0.037 14.1 0.0 0.069 13.3 0.0 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis central region Herpes_ORF11 PF04797.13 PIK37105.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus dUTPase protein zf-CCHC PF00098.23 PIK37106.1 - 4.8e-08 32.7 1.4 9.2e-08 31.8 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37106.1 - 2.2e-05 24.2 0.6 4.7e-05 23.1 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK37106.1 - 0.0038 17.2 0.3 0.0079 16.1 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle Katanin_con80 PF13925.6 PIK37107.1 - 0.027 14.5 0.6 25 4.9 0.1 3.2 3 0 0 3 3 3 0 con80 domain of Katanin ocr PF08684.10 PIK37107.1 - 0.027 14.9 4.6 4.5 7.8 0.1 3.7 3 1 0 3 3 3 0 DNA mimic ocr Serglycin PF04360.12 PIK37107.1 - 1 9.3 18.1 8.1 6.4 0.6 4.3 3 1 0 3 3 3 0 Serglycin Amelogenin PF02948.15 PIK37107.1 - 6.7 7.3 13.3 3.1 8.4 2.9 2.9 1 1 2 3 3 3 0 Amelogenin TraB PF01963.17 PIK37108.1 - 2e-50 172.1 0.0 2.3e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 TraB family DUF3261 PF11659.8 PIK37108.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3261) PNMA PF14893.6 PIK37109.1 - 1.9e-16 60.4 0.0 2.1e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 PNMA RVT_1 PF00078.27 PIK37110.1 - 2.5e-32 112.2 0.0 3.4e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mce4_CUP1 PF11887.8 PIK37110.1 - 0.075 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative RT_RNaseH_2 PF17919.1 PIK37111.1 - 5.2e-25 87.4 0.0 1.2e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37111.1 - 1.6e-15 57.2 0.4 1.1e-14 54.5 0.0 2.3 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK37111.1 - 5.2e-13 49.2 0.0 9.3e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Sld7_C PF18596.1 PIK37111.1 - 0.13 12.4 0.0 0.38 10.9 0.0 1.7 1 1 1 2 2 2 0 Sld7 C-terminal domain zf-CCHC PF00098.23 PIK37113.1 - 1e-07 31.7 1.9 2.3e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37113.1 - 0.00036 20.3 0.1 0.00036 20.3 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37113.1 - 0.13 12.0 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK37113.1 - 0.19 11.8 0.3 0.45 10.6 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK37113.1 - 0.24 11.2 0.5 0.5 10.1 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK37114.1 - 8.9e-38 128.4 0.1 1.5e-37 127.6 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37114.1 - 4.3e-34 117.0 0.1 8e-34 116.1 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37114.1 - 2.8e-10 40.1 0.0 5e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK37114.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase rve PF00665.26 PIK37115.1 - 8.8e-23 80.8 0.0 1.6e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37115.1 - 0.0059 16.4 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK37115.1 - 0.024 15.1 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 MycE methyltransferase N-terminal MAPEG PF01124.18 PIK37116.1 - 4.5e-21 75.1 0.0 5.3e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 MAPEG family PDZ PF00595.24 PIK37117.1 - 6.8e-05 23.1 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK37117.1 - 0.00011 22.0 0.0 0.00032 20.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain RVT_1 PF00078.27 PIK37118.1 - 7.4e-42 143.4 0.1 9.2e-42 143.0 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5595 PF18077.1 PIK37119.1 - 0.11 12.6 0.1 0.27 11.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Fibrinogen_C PF00147.18 PIK37120.1 - 4.3e-43 147.7 15.4 7.7e-43 146.9 15.4 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK37120.1 - 3.7e-07 30.0 13.8 3.7e-07 30.0 13.8 4.6 2 2 2 4 4 4 1 TILa domain TIL PF01826.17 PIK37120.1 - 5.7e-06 26.5 14.7 5.7e-06 26.5 14.7 4.7 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK37121.1 - 2.6e-48 164.8 6.3 2.4e-38 132.2 0.5 3.2 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK37121.1 - 4.4e-10 39.4 12.8 4.4e-10 39.4 12.8 3.9 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK37121.1 - 1e-06 28.8 16.6 1e-06 28.8 16.6 3.6 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK37121.1 - 0.00016 21.8 10.2 0.00016 21.8 10.2 4.1 2 2 1 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK37122.1 - 1.6e-48 165.4 2.2 1.7e-40 139.1 0.5 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK37122.1 - 3.8e-10 39.6 9.6 3.8e-10 39.6 9.6 4.1 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK37122.1 - 3.3e-06 27.3 14.9 3.3e-06 27.3 14.9 4.0 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK37122.1 - 0.0054 16.9 11.5 0.0054 16.9 11.5 4.4 4 1 0 4 4 4 1 EGF domain EGF_MSP1_1 PF12946.7 PIK37122.1 - 8.9 6.5 36.3 1.4 9.0 8.7 3.9 3 0 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK37123.1 - 3.8e-42 144.6 15.9 6.3e-42 143.9 15.9 1.4 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK37123.1 - 3.6e-05 23.9 12.3 3.6e-05 23.9 12.3 2.8 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK37124.1 - 4.9e-35 121.3 0.1 6.9e-35 120.9 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK37124.1 - 1.2e-06 28.6 16.8 1.2e-06 28.6 16.8 1.8 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain ADP_PFK_GK PF04587.15 PIK37125.1 - 0.028 13.0 0.1 0.037 12.6 0.1 1.1 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region TcdB_N PF12918.7 PIK37125.1 - 0.12 12.7 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain rve PF00665.26 PIK37126.1 - 8.6e-05 22.7 0.0 0.0004 20.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Sigma70_r4_2 PF08281.12 PIK37126.1 - 0.0013 18.4 0.0 0.0091 15.7 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 PIK37126.1 - 0.0062 16.3 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 PIK37126.1 - 0.013 15.6 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix GerE PF00196.19 PIK37126.1 - 0.074 12.6 0.1 0.074 12.6 0.1 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Phage_GP20 PF06810.11 PIK37126.1 - 0.14 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 HECT PF00632.25 PIK37127.1 - 3.3e-10 40.0 0.0 3.4e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Cation_efflux PF01545.21 PIK37128.1 - 6.5e-32 110.9 1.2 8.2e-32 110.6 1.2 1.1 1 0 0 1 1 1 1 Cation efflux family EAV_GS PF01309.18 PIK37128.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein UAA PF08449.11 PIK37129.1 - 5.7e-74 249.0 12.6 6.8e-74 248.8 12.6 1.1 1 0 0 1 1 1 1 UAA transporter family CLAG PF03805.13 PIK37129.1 - 0.22 9.0 0.4 0.3 8.6 0.4 1.1 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein p450 PF00067.22 PIK37130.1 - 1.8e-105 353.4 0.0 2.2e-105 353.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Herpes_IE68 PF02479.16 PIK37130.1 - 0.022 14.4 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus immediate early protein THAP PF05485.12 PIK37131.1 - 3.5e-13 50.3 0.1 5.3e-13 49.7 0.1 1.3 1 0 0 1 1 1 1 THAP domain SRCR PF00530.18 PIK37132.1 - 8e-187 607.1 69.7 1e-29 103.0 4.6 7.0 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK37132.1 - 6.6e-40 135.6 32.1 5.2e-06 26.9 0.5 6.5 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK37132.1 - 1.7e-19 70.3 0.3 0.25 11.9 0.0 6.6 6 1 0 6 6 6 6 Hepsin, SRCR domain DUF333 PF03891.15 PIK37132.1 - 3e-06 27.3 0.0 67 3.8 0.0 6.7 6 0 0 6 6 6 0 Domain of unknown function (DUF333) TcfC PF16967.5 PIK37132.1 - 0.00028 20.3 3.2 31 4.1 0.0 6.1 6 0 0 6 6 6 0 E-set like domain DUF2793 PF10983.8 PIK37132.1 - 0.68 9.8 9.8 3 7.8 0.1 5.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2793) DUF3504 PF12012.8 PIK37133.1 - 0.025 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Integrase_H2C2 PF17921.1 PIK37134.1 - 2.9e-20 72.1 0.0 4.6e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK37134.1 - 9.8e-17 61.2 0.0 2.4e-16 60.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK37134.1 - 0.00033 20.8 0.0 0.00072 19.7 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK37134.1 - 0.0011 18.6 0.0 0.0049 16.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK37135.1 - 7.2e-19 68.2 0.0 1.1e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) bZIP_1 PF00170.21 PIK37136.1 - 8.4e-05 22.6 11.6 0.00017 21.6 11.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK37136.1 - 0.0017 18.4 10.7 0.0029 17.6 10.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper Tau95_N PF17682.1 PIK37136.1 - 0.027 14.7 1.3 0.042 14.1 1.3 1.4 1 0 0 1 1 1 0 Tau95 Triple barrel domain Jnk-SapK_ap_N PF09744.9 PIK37136.1 - 0.19 11.9 7.1 0.29 11.4 7.1 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Pkinase_Tyr PF07714.17 PIK37137.1 - 1.5e-27 96.6 0.0 2.1e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37137.1 - 3.2e-22 79.1 0.0 5.4e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK37137.1 - 2.9e-11 43.3 0.1 2.2e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK37137.1 - 0.00064 20.3 0.2 0.18 12.4 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Kinase-like PF14531.6 PIK37137.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like NACHT PF05729.12 PIK37138.1 - 1.4e-20 73.9 0.0 4.7e-20 72.1 0.0 2.0 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK37138.1 - 9.5e-08 32.5 4.2 4.5e-05 24.0 0.1 4.5 4 1 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK37138.1 - 1.8e-06 27.9 1.1 1.5e-05 24.9 0.2 2.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK37138.1 - 1.2e-05 25.4 4.3 0.0002 21.5 0.4 3.7 4 0 0 4 4 4 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK37138.1 - 2e-05 24.6 0.1 0.36 10.9 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK37138.1 - 0.00032 20.8 1.3 0.0086 16.2 0.2 3.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK37138.1 - 0.014 15.7 4.7 0.33 11.3 0.4 3.9 3 1 0 3 3 3 0 Immunoglobulin domain TMEM154 PF15102.6 PIK37138.1 - 0.02 14.8 0.0 0.046 13.6 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF2075 PF09848.9 PIK37138.1 - 0.037 13.3 0.1 0.16 11.2 0.0 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 PIK37138.1 - 0.054 13.1 0.0 0.2 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 PIK37138.1 - 0.065 12.6 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 PIK37138.1 - 0.072 13.4 0.0 0.34 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Halogen_Hydrol PF10112.9 PIK37138.1 - 0.073 13.1 0.1 19 5.2 0.0 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Adeno_E3_CR1 PF02440.15 PIK37138.1 - 0.18 11.6 2.9 2.2 8.1 0.8 2.9 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Abhydrolase_1 PF00561.20 PIK37139.1 - 2.3e-27 96.3 0.0 1.9e-23 83.4 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold HAD_2 PF13419.6 PIK37139.1 - 1.4e-11 44.8 0.0 2.4e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Abhydrolase_6 PF12697.7 PIK37139.1 - 4.1e-11 43.9 0.1 6.7e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK37139.1 - 1e-09 38.0 0.0 4.1e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase PF00702.26 PIK37139.1 - 6.4e-07 29.9 0.0 1.3e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK37139.1 - 0.00043 20.3 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 PIK37139.1 - 0.12 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Glyoxalase_4 PF13669.6 PIK37139.1 - 0.19 12.0 0.0 0.9 9.8 0.0 2.2 3 0 0 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CLZ PF16526.5 PIK37140.1 - 1.6e-21 76.5 7.7 2.8e-21 75.6 5.4 2.4 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 PIK37140.1 - 6.2e-21 74.3 0.0 1e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Occludin_ELL PF07303.13 PIK37140.1 - 0.33 11.7 10.7 4.9 7.9 0.2 3.2 2 1 1 3 3 3 0 Occludin homology domain Nup54 PF13874.6 PIK37140.1 - 0.54 10.3 11.2 0.13 12.3 6.6 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 TMPIT PF07851.13 PIK37140.1 - 4 6.6 5.9 6.3 5.9 5.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin-6_N PF09177.11 PIK37140.1 - 6.1 7.5 9.1 2.9 8.5 6.5 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Swm2 PF17083.5 PIK37141.1 - 0.011 15.7 0.1 0.023 14.7 0.1 1.5 1 1 0 1 1 1 0 Nucleolar protein Swm2 Pou PF00157.17 PIK37142.1 - 1.4e-30 105.1 0.0 2.9e-30 104.1 0.0 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK37142.1 - 1.8e-17 62.9 1.7 3.5e-17 62.0 1.7 1.5 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 PIK37142.1 - 0.00012 22.4 0.8 0.0081 16.5 0.1 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain Homeobox_KN PF05920.11 PIK37142.1 - 0.099 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF4770 PF15994.5 PIK37142.1 - 0.11 12.7 0.4 0.18 12.0 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) zf-C3HC4_2 PF13923.6 PIK37143.1 - 5.7e-08 32.5 12.1 1.3e-07 31.3 12.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK37143.1 - 2.7e-07 30.3 9.4 6.8e-07 29.0 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK37143.1 - 1.2e-06 28.7 11.4 1.2e-06 28.7 11.4 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK37143.1 - 2.5e-05 24.1 11.1 6.7e-05 22.7 11.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 PIK37143.1 - 0.00019 21.0 7.5 0.00038 20.1 7.5 1.4 1 0 0 1 1 1 1 P-11 zinc finger MPS2 PF17060.5 PIK37143.1 - 0.0017 17.7 3.3 0.0017 17.7 3.3 1.5 2 0 0 2 2 2 1 Monopolar spindle protein 2 zf-RING_UBOX PF13445.6 PIK37143.1 - 0.0044 17.0 11.2 0.014 15.4 11.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger YabA PF06156.13 PIK37143.1 - 0.0051 17.4 6.7 0.013 16.1 0.6 3.0 2 1 1 3 3 3 1 Initiation control protein YabA NRBF2 PF08961.10 PIK37143.1 - 0.027 14.1 1.0 0.054 13.1 0.3 1.8 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 PIK37143.1 - 0.028 14.2 7.1 0.32 10.8 0.3 3.3 2 1 1 3 3 3 0 Septum formation initiator zf-RING_5 PF14634.6 PIK37143.1 - 0.055 13.4 9.3 0.14 12.1 9.3 1.8 1 0 0 1 1 1 0 zinc-RING finger domain bZIP_1 PF00170.21 PIK37143.1 - 0.057 13.5 11.3 0.87 9.7 1.0 3.3 2 1 1 3 3 3 0 bZIP transcription factor zf-rbx1 PF12678.7 PIK37143.1 - 0.058 13.7 13.6 0.045 14.1 10.7 2.3 2 1 0 2 2 2 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 PIK37143.1 - 0.07 13.0 17.4 0.027 14.3 13.3 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF1272 PF06906.11 PIK37143.1 - 0.14 12.3 4.2 0.32 11.1 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) KxDL PF10241.9 PIK37143.1 - 0.22 11.8 3.9 0.29 11.4 2.3 2.0 1 1 1 2 2 1 0 Uncharacterized conserved protein HAP1_N PF04849.13 PIK37143.1 - 0.26 10.5 9.8 0.27 10.4 1.4 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region ZapB PF06005.12 PIK37143.1 - 0.27 11.7 10.8 0.61 10.6 0.8 3.5 3 1 0 3 3 3 0 Cell division protein ZapB ATG16 PF08614.11 PIK37143.1 - 0.3 11.3 11.2 12 6.1 11.3 2.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_2 PF07716.15 PIK37143.1 - 0.32 11.1 7.1 26 5.0 0.3 3.5 3 0 0 3 3 3 0 Basic region leucine zipper UPF0242 PF06785.11 PIK37143.1 - 0.69 10.0 7.3 1.6 8.8 6.6 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PRKG1_interact PF15898.5 PIK37143.1 - 0.77 10.7 9.5 1.5 9.8 2.3 3.0 2 2 0 2 2 2 0 cGMP-dependent protein kinase interacting domain BLOC1_2 PF10046.9 PIK37143.1 - 0.78 10.1 4.0 4.7 7.6 1.7 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HAUS-augmin3 PF14932.6 PIK37143.1 - 0.85 9.1 10.7 0.4 10.2 1.3 2.8 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Prefoldin_2 PF01920.20 PIK37143.1 - 0.98 9.4 12.2 3.8 7.5 1.7 3.0 2 1 0 2 2 2 0 Prefoldin subunit zf-C3HC4_4 PF15227.6 PIK37143.1 - 1 9.6 10.9 2.4 8.4 10.9 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF2205 PF10224.9 PIK37143.1 - 1.3 9.1 4.9 0.71 9.9 0.2 2.7 3 0 0 3 3 3 0 Short coiled-coil protein zf-RING_4 PF14570.6 PIK37143.1 - 5.2 6.9 8.2 14 5.5 8.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SlyX PF04102.12 PIK37143.1 - 7.7 7.2 9.0 5.9 7.6 1.1 3.1 3 1 1 4 4 2 0 SlyX Csm1_N PF18504.1 PIK37143.1 - 9.1 6.7 9.7 7.4 7.0 1.0 3.4 3 0 0 3 3 3 0 Csm1 N-terminal domain SBF_like PF13593.6 PIK37144.1 - 1.8e-76 257.5 19.7 2.2e-76 257.1 19.7 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 PIK37144.1 - 1.9e-17 63.6 9.8 1.9e-17 63.6 9.8 2.4 1 1 2 3 3 3 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK37144.1 - 6.4e-09 34.7 0.8 1.3e-05 23.8 0.0 2.6 2 1 0 2 2 2 2 Membrane transport protein TMEM70 PF06979.12 PIK37144.1 - 0.086 13.3 0.6 0.086 13.3 0.6 2.4 3 1 0 3 3 3 0 Assembly, mitochondrial proton-transport ATP synth complex SBF_like PF13593.6 PIK37145.1 - 2.1e-39 135.7 9.8 1.9e-32 112.9 3.3 2.0 1 1 1 2 2 2 2 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 PIK37145.1 - 4.5e-10 39.5 6.1 3.7e-09 36.5 3.4 2.1 1 1 1 2 2 2 2 Sodium Bile acid symporter family TMEM70 PF06979.12 PIK37145.1 - 0.02 15.3 0.6 0.02 15.3 0.6 2.0 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex AMP-binding PF00501.28 PIK37146.1 - 4.1e-86 289.2 0.0 5.3e-86 288.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK37146.1 - 7.8e-13 49.2 0.0 1.8e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PDZ_5 PF17817.1 PIK37147.1 - 1.2e-24 86.3 0.3 1.2e-24 86.3 0.3 3.0 3 0 0 3 3 3 1 PDZ domain Sarcoglycan_2 PF05510.13 PIK37148.1 - 3.1e-39 134.9 0.6 1.2e-38 132.9 0.6 1.7 1 1 0 1 1 1 1 Sarcoglycan alpha/epsilon He_PIG PF05345.12 PIK37148.1 - 0.0004 20.5 0.1 0.00094 19.3 0.1 1.5 1 0 0 1 1 1 1 Putative Ig domain TMEM154 PF15102.6 PIK37148.1 - 0.0012 18.7 0.0 0.0025 17.7 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 PIK37148.1 - 0.05 13.4 0.2 1.3 8.8 0.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) POC3_POC4 PF10448.9 PIK37148.1 - 0.1 12.6 0.0 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 LRR_4 PF12799.7 PIK37149.1 - 3.6e-20 71.7 0.7 6.9e-05 23.1 0.1 6.8 3 3 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK37149.1 - 5.1e-20 69.8 10.7 0.017 15.1 0.1 9.5 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 PIK37149.1 - 4.7e-09 35.6 7.3 8.9 7.3 0.0 7.6 7 1 0 7 7 7 3 Leucine Rich Repeat LRR_8 PF13855.6 PIK37149.1 - 4.8e-05 23.0 0.4 1.9 8.3 0.3 5.1 4 2 2 6 6 6 2 Leucine rich repeat LRR_5 PF13306.6 PIK37149.1 - 0.0049 16.8 1.1 0.27 11.2 0.1 3.2 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 PIK37149.1 - 0.015 15.4 4.0 2.5 8.4 0.1 4.2 2 2 2 4 4 4 0 UPF0731 family IL4 PF00727.18 PIK37149.1 - 3.1 8.1 6.8 1.6 9.0 4.1 1.9 2 0 0 2 2 2 0 Interleukin 4 MSC PF09402.10 PIK37150.1 - 4.5e-25 88.8 5.9 4.5e-25 88.8 5.9 1.5 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain LEM PF03020.15 PIK37150.1 - 3.6e-14 52.0 0.4 6.2e-14 51.3 0.4 1.4 1 0 0 1 1 1 1 LEM domain RBM39linker PF15519.6 PIK37150.1 - 0.005 17.9 0.1 0.005 17.9 0.1 2.7 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein DUF2207 PF09972.9 PIK37150.1 - 0.033 13.0 0.0 3.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PspB PF06667.12 PIK37150.1 - 0.15 12.1 1.2 0.47 10.5 1.2 1.9 1 0 0 1 1 1 0 Phage shock protein B Vpu PF00558.19 PIK37150.1 - 0.17 11.6 4.8 7.2 6.5 0.5 2.6 2 0 0 2 2 2 0 Vpu protein Gemini_mov PF01708.16 PIK37150.1 - 0.86 9.4 2.6 2.3 8.1 0.5 2.3 2 0 0 2 2 2 0 Geminivirus putative movement protein LapA_dom PF06305.11 PIK37150.1 - 1.4 8.7 6.2 1.1 9.2 0.3 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Sigma_reg_N PF13800.6 PIK37150.1 - 5.2 7.4 5.7 1.1 9.6 0.6 2.4 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Lectin_C PF00059.21 PIK37151.1 - 7.3e-08 33.1 0.1 1.1e-07 32.6 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain C8 PF08742.11 PIK37151.1 - 0.0037 17.6 0.4 0.0068 16.8 0.4 1.4 1 0 0 1 1 1 1 C8 domain rve PF00665.26 PIK37152.1 - 0.062 13.5 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain HTH_21 PF13276.6 PIK37152.1 - 0.42 10.8 3.5 0.39 10.9 0.2 2.6 2 0 0 2 2 2 0 HTH-like domain RVT_1 PF00078.27 PIK37154.1 - 2.3e-31 109.0 0.0 2.6e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1731 PF08338.11 PIK37155.1 - 2e-15 56.3 0.0 3.2e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 PIK37155.1 - 0.079 12.4 0.0 0.13 11.8 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family eIF_4EBP PF05456.11 PIK37156.1 - 0.017 15.1 0.1 0.12 12.3 0.0 2.4 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) NHL PF01436.21 PIK37157.1 - 4.7e-58 190.4 13.0 2.5e-09 36.7 0.2 7.0 6 0 0 6 6 6 6 NHL repeat Filamin PF00630.19 PIK37157.1 - 5.7e-17 62.4 0.0 1.5e-16 61.1 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF5128 PF17170.4 PIK37157.1 - 1.4e-11 44.1 4.2 0.00012 21.3 0.6 4.2 2 1 1 4 4 4 3 6-bladed beta-propeller SGL PF08450.12 PIK37157.1 - 8.3e-10 38.7 0.3 1.8e-05 24.4 0.1 4.4 2 1 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 PIK37157.1 - 4.5e-08 33.1 27.8 8.2e-07 29.1 11.2 4.0 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4 PF00097.25 PIK37157.1 - 6.3e-08 32.4 10.1 6.3e-08 32.4 10.1 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK37157.1 - 1.9e-07 31.0 9.9 1.9e-07 31.0 9.9 2.9 3 0 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK37157.1 - 2.2e-07 30.6 10.8 2.2e-07 30.6 10.8 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK37157.1 - 1.1e-05 25.1 7.0 1.1e-05 25.1 7.0 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK37157.1 - 3.1e-05 23.8 7.4 3.1e-05 23.8 7.4 3.6 3 1 0 3 3 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK37157.1 - 3.5e-05 23.9 10.5 3.5e-05 23.9 10.5 3.4 3 1 0 3 3 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK37157.1 - 0.0001 22.1 8.1 0.0001 22.1 8.1 3.6 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK37157.1 - 0.00081 19.7 10.4 0.00081 19.7 10.4 3.4 3 0 0 3 3 3 1 Ring finger domain Phasin PF05597.11 PIK37157.1 - 0.0015 18.5 7.3 0.0029 17.6 7.3 1.4 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.12 PIK37157.1 - 0.0019 18.3 1.8 0.0034 17.4 1.8 1.4 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phytase-like PF13449.6 PIK37157.1 - 0.0036 17.3 0.1 17 5.2 0.0 4.1 1 1 0 2 2 2 0 Esterase-like activity of phytase LOH1CR12 PF10158.9 PIK37157.1 - 0.008 16.2 4.5 0.016 15.2 4.5 1.4 1 0 0 1 1 1 1 Tumour suppressor protein F_actin_cap_B PF01115.17 PIK37157.1 - 0.021 14.5 0.2 0.035 13.7 0.2 1.3 1 0 0 1 1 1 0 F-actin capping protein, beta subunit ANAPC4_WD40 PF12894.7 PIK37157.1 - 0.034 14.4 0.0 3.2 8.1 0.0 3.5 4 0 0 4 4 3 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_13 PF13166.6 PIK37157.1 - 0.057 12.1 3.4 0.084 11.5 3.4 1.1 1 0 0 1 1 1 0 AAA domain DUF839 PF05787.13 PIK37157.1 - 0.084 12.0 0.4 9.7 5.2 0.0 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF839) ARA70 PF12489.8 PIK37157.1 - 0.13 12.4 3.1 0.24 11.6 3.1 1.5 1 0 0 1 1 1 0 Nuclear coactivator zf-Nse PF11789.8 PIK37157.1 - 0.51 10.2 5.9 1 9.2 5.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Spc7 PF08317.11 PIK37157.1 - 1.4 7.7 11.0 2.1 7.1 11.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Syntaxin_2 PF14523.6 PIK37157.1 - 2.3 8.7 7.1 57 4.2 6.8 2.8 2 1 0 2 2 2 0 Syntaxin-like protein HYR PF02494.16 PIK37158.1 - 2.6e-169 550.0 80.4 2.7e-22 78.9 0.2 14.3 14 0 0 14 14 14 14 HYR domain EGF PF00008.27 PIK37158.1 - 3.8e-22 78.2 153.6 8.9e-06 25.9 6.0 11.4 10 0 0 10 10 10 8 EGF-like domain hEGF PF12661.7 PIK37158.1 - 6.9e-05 23.3 136.4 0.049 14.3 4.5 12.6 12 0 0 12 12 12 8 Human growth factor-like EGF ATP-synt_C PF00137.21 PIK37158.1 - 0.0041 17.4 0.2 0.0092 16.3 0.2 1.5 1 0 0 1 1 1 1 ATP synthase subunit C DUF5011 PF16403.5 PIK37158.1 - 0.093 12.9 8.8 1.4e+02 2.7 0.0 6.7 7 0 0 7 7 7 0 Domain of unknown function (DUF5011) Glyco_transf_29 PF00777.18 PIK37159.1 - 5.7e-33 114.5 0.6 7.8e-33 114.0 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Cytochrome-c551 PF10643.9 PIK37159.1 - 0.08 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 NARP1 PF12569.8 PIK37160.1 - 2.8e-190 633.6 19.7 2.8e-190 633.6 19.7 1.6 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 PIK37160.1 - 1.6e-20 71.5 11.3 0.00077 19.4 0.0 8.1 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK37160.1 - 1e-14 53.9 0.2 0.024 15.4 0.0 8.4 5 2 3 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK37160.1 - 3.1e-14 51.9 19.8 0.0019 18.3 0.0 8.2 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK37160.1 - 4.1e-14 51.7 13.0 0.0061 16.3 0.1 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 PIK37160.1 - 3.9e-11 42.2 6.8 0.1 12.7 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK37160.1 - 1.4e-10 41.5 13.1 0.037 14.5 0.0 6.8 7 1 2 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK37160.1 - 7.4e-10 38.9 16.7 0.0023 18.1 0.1 5.4 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK37160.1 - 6e-09 35.5 2.2 0.00053 19.6 0.1 4.5 4 0 0 4 4 4 2 TPR repeat TPR_12 PF13424.6 PIK37160.1 - 3.8e-08 33.5 11.4 1.1 9.7 0.0 7.0 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK37160.1 - 5e-07 30.3 0.2 0.034 14.8 0.0 4.7 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK37160.1 - 4.6e-06 26.1 5.0 0.19 10.9 0.4 4.9 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK37160.1 - 3.6e-05 23.3 6.3 0.014 14.7 1.3 3.2 2 2 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 PIK37160.1 - 5.9e-05 23.3 0.0 27 5.8 0.0 6.5 8 0 0 8 8 7 0 Tetratricopeptide repeat PknG_TPR PF16918.5 PIK37160.1 - 0.00041 19.2 0.2 0.0052 15.6 0.0 2.2 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_9 PF13371.6 PIK37160.1 - 0.002 18.2 4.5 0.22 11.7 0.3 4.8 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK37160.1 - 0.002 18.6 17.2 0.39 11.4 0.0 7.5 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK37160.1 - 0.0033 17.3 3.0 4.1 7.4 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat PPR PF01535.20 PIK37160.1 - 0.01 16.1 12.4 0.81 10.1 0.0 6.7 9 0 0 9 9 7 1 PPR repeat PPR_2 PF13041.6 PIK37160.1 - 0.035 14.3 3.9 3.6 7.8 0.0 4.8 5 0 0 5 5 5 0 PPR repeat family TPR_17 PF13431.6 PIK37160.1 - 0.074 13.5 3.0 59 4.4 0.0 5.6 7 0 0 7 7 5 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK37160.1 - 0.086 12.5 11.0 0.11 12.2 0.4 4.2 3 1 0 3 3 2 0 26S proteasome subunit RPN7 TPR_21 PF09976.9 PIK37160.1 - 0.12 12.1 0.1 0.12 12.1 0.1 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain Coilin_N PF15862.5 PIK37160.1 - 0.95 9.3 9.6 4.2 7.2 9.9 1.9 2 0 0 2 2 2 0 Coilin N-terminus UCH_C PF18031.1 PIK37161.1 - 1.8e-18 66.2 0.1 1.8e-18 66.2 0.1 2.8 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolases DUF5384 PF17358.2 PIK37161.1 - 0.017 15.2 1.6 0.017 15.2 1.6 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5384) Aldedh PF00171.22 PIK37161.1 - 0.082 11.4 0.3 0.15 10.5 0.3 1.3 1 0 0 1 1 1 0 Aldehyde dehydrogenase family DivIC PF04977.15 PIK37161.1 - 1.6 8.5 5.4 18 5.2 0.5 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF4140 PF13600.6 PIK37161.1 - 1.7 9.2 5.8 6.1 7.4 1.0 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ETC_C1_NDUFA5 PF04716.14 PIK37162.1 - 1.4e-22 79.3 0.3 1.8e-22 78.9 0.3 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region GLF PF03275.13 PIK37162.1 - 0.02 14.6 0.1 0.025 14.3 0.1 1.1 1 0 0 1 1 1 0 UDP-galactopyranose mutase TPR_12 PF13424.6 PIK37163.1 - 2.7e-17 62.8 7.5 1.2e-06 28.7 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF4062 PF13271.6 PIK37163.1 - 3.1e-13 49.9 0.1 3e-12 46.7 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) TPR_10 PF13374.6 PIK37163.1 - 3e-10 39.6 7.6 0.00011 22.0 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK37163.1 - 7.4e-06 25.7 6.3 1.9 8.8 0.4 5.3 4 0 0 4 4 4 2 Tetratricopeptide repeat AAA_16 PF13191.6 PIK37163.1 - 0.0016 18.9 0.0 0.0047 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain TPR_1 PF00515.28 PIK37163.1 - 0.0021 17.8 6.6 3 7.8 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK37163.1 - 0.0022 17.9 1.7 14 6.0 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK37163.1 - 0.6 10.5 7.2 9.8 6.7 0.0 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat Tubulin PF00091.25 PIK37164.1 - 2.3e-68 230.3 0.0 3.1e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK37164.1 - 1.9e-52 176.7 0.0 3e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK37164.1 - 0.00037 20.2 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain RabGAP-TBC PF00566.18 PIK37165.1 - 2.4e-53 181.0 1.4 4e-53 180.3 1.4 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Macoilin PF09726.9 PIK37165.1 - 0.74 8.3 6.2 1 7.8 6.2 1.2 1 0 0 1 1 1 0 Macoilin family TFIIF_alpha PF05793.12 PIK37165.1 - 0.91 8.0 15.6 1.3 7.5 15.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DAGK_cat PF00781.24 PIK37166.1 - 8.2e-27 93.3 0.1 1.5e-26 92.5 0.1 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 PIK37166.1 - 0.043 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 ATP-NAD kinase G6PD_C PF02781.16 PIK37167.1 - 2.7e-89 299.2 0.0 3.3e-89 298.9 0.0 1.0 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain Integrin_alpha2 PF08441.12 PIK37168.1 - 1.6e-64 218.6 0.0 2e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha MLANA PF14991.6 PIK37168.1 - 0.0098 16.2 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein melan-A LYRIC PF15686.5 PIK37168.1 - 0.027 14.0 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4381 PF14316.6 PIK37168.1 - 0.25 11.6 0.4 0.43 10.8 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Integrin_alpha2 PF08441.12 PIK37169.1 - 2.6e-12 46.4 0.3 1.8e-10 40.3 0.3 2.0 1 1 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK37170.1 - 3.4e-16 59.1 32.2 7.6e-06 26.0 2.3 6.5 6 0 0 6 6 6 4 FG-GAP repeat VCBS PF13517.6 PIK37170.1 - 3.1e-08 34.1 12.3 4.9e-05 23.8 2.6 4.1 3 1 1 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HisK_sensor PF18698.1 PIK37170.1 - 0.25 11.7 0.6 7.7 6.9 0.1 2.9 3 0 0 3 3 3 0 Histidine kinase sensor domain FG-GAP_2 PF14312.6 PIK37170.1 - 0.26 11.6 19.5 0.48 10.7 0.9 6.0 8 0 0 8 8 8 0 FG-GAP repeat Thiolase_N PF00108.23 PIK37171.1 - 2.8e-78 262.9 2.3 3.8e-78 262.5 2.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK37171.1 - 2e-49 166.3 0.2 4.2e-49 165.3 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 PIK37171.1 - 3.9e-05 23.4 0.3 0.00012 21.8 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 PIK37171.1 - 0.00015 21.9 0.0 0.00097 19.3 0.0 2.5 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 PIK37171.1 - 0.0055 16.5 0.7 2.1 8.2 0.1 2.6 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Dodecin PF07311.12 PIK37171.1 - 0.068 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Dodecin DUF2451 PF10474.9 PIK37172.1 - 4.7e-86 288.4 0.2 6.3e-86 287.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Gal4_dimer PF03902.13 PIK37172.1 - 0.056 13.6 0.0 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 Gal4-like dimerisation domain DUF3160 PF11369.8 PIK37173.1 - 0.032 12.7 0.5 0.24 9.8 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3160) PET122 PF05476.11 PIK37173.1 - 0.093 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 PET122 Vps54_N PF10475.9 PIK37174.1 - 3.9e-35 121.6 1.5 4.5e-35 121.4 1.5 1.0 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex YsaB PF13983.6 PIK37174.1 - 0.0029 17.8 0.1 0.0051 17.1 0.1 1.4 1 1 0 1 1 1 1 YsaB-like lipoprotein DUF3498 PF12004.8 PIK37175.1 - 3.6e-12 46.3 17.3 5.8e-12 45.6 17.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) SlyX PF04102.12 PIK37175.1 - 0.016 15.8 0.5 0.016 15.8 0.5 3.1 3 1 0 3 3 3 0 SlyX FlaC_arch PF05377.11 PIK37175.1 - 0.026 14.9 8.9 0.15 12.5 1.0 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 PIK37175.1 - 0.028 14.9 4.5 0.028 14.9 4.5 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 CENP-H PF05837.12 PIK37175.1 - 0.04 14.3 1.6 0.04 14.3 1.6 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Fibin PF15819.5 PIK37175.1 - 0.096 12.4 4.2 0.048 13.4 1.8 1.5 1 1 0 1 1 1 0 Fin bud initiation factor homologue YojJ PF10372.9 PIK37175.1 - 0.099 12.7 3.9 0.17 12.0 0.1 2.7 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus DUF848 PF05852.11 PIK37175.1 - 0.2 11.8 8.4 0.08 13.1 0.7 2.3 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CreD PF06123.12 PIK37175.1 - 0.25 10.1 0.9 0.34 9.6 0.9 1.1 1 0 0 1 1 1 0 Inner membrane protein CreD GAS PF13851.6 PIK37175.1 - 0.3 10.4 23.4 0.19 11.1 5.8 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 PIK37175.1 - 0.55 10.1 10.6 0.16 11.8 1.0 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 PIK37175.1 - 0.63 10.2 23.5 0.23 11.7 9.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Tup_N PF08581.10 PIK37175.1 - 1.2 9.5 13.4 1.2 9.5 3.1 3.0 2 1 0 2 2 2 0 Tup N-terminal Herpes_UL6 PF01763.16 PIK37175.1 - 6.9 5.1 11.0 0.14 10.6 1.0 2.0 1 1 1 2 2 2 0 Herpesvirus UL6 like RasGAP PF00616.19 PIK37176.1 - 2.6e-21 76.3 0.4 8.9e-16 58.2 0.1 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 PIK37178.1 - 0.0043 17.6 0.1 0.0088 16.5 0.1 1.8 1 1 0 1 1 1 1 PH domain PH_2 PF08458.10 PIK37178.1 - 0.031 14.6 0.1 0.067 13.6 0.1 1.7 1 1 0 1 1 1 0 Plant pleckstrin homology-like region Phage_int_SAM_1 PF02899.17 PIK37179.1 - 5.5e-05 23.4 1.0 0.00019 21.7 0.1 2.2 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK37179.1 - 0.00022 21.7 0.0 0.00049 20.5 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain DUF2722 PF10846.8 PIK37180.1 - 0.012 14.6 2.1 0.014 14.4 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Ins134_P3_kin PF05770.11 PIK37180.1 - 0.061 12.8 0.2 0.072 12.6 0.2 1.0 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Bombinin PF05298.11 PIK37180.1 - 0.1 12.3 0.3 0.16 11.6 0.3 1.4 1 1 0 1 1 1 0 Bombinin PAP_assoc PF03828.19 PIK37181.1 - 2.1e-11 43.8 0.4 5.8e-11 42.4 0.4 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase PsaA_PsaB PF00223.19 PIK37181.1 - 0.036 12.3 0.1 0.045 11.9 0.1 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein FAM219A PF15260.6 PIK37181.1 - 0.42 11.0 3.0 0.68 10.3 3.0 1.4 1 0 0 1 1 1 0 Protein family FAM219A AF-4 PF05110.13 PIK37181.1 - 0.68 7.9 20.5 0.87 7.6 20.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Acyl_transf_1 PF00698.21 PIK37182.1 - 7.8e-10 38.8 0.1 1.2e-09 38.1 0.1 1.2 1 0 0 1 1 1 1 Acyl transferase domain SelP_C PF04593.14 PIK37182.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, C terminal region FAM198 PF15051.6 PIK37183.1 - 0.0015 17.4 0.0 0.0015 17.4 0.0 1.1 1 0 0 1 1 1 1 FAM198 protein Fam20C PF06702.12 PIK37184.1 - 5.7e-54 183.2 0.1 6.3e-54 183.1 0.1 1.0 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 CotH PF08757.11 PIK37184.1 - 0.021 14.4 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 CotH kinase protein Fam20C PF06702.12 PIK37185.1 - 1.5e-12 47.8 1.3 2e-12 47.4 0.1 1.8 2 0 0 2 2 2 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK37185.1 - 0.0073 15.2 0.0 0.0094 14.9 0.0 1.2 1 0 0 1 1 1 1 FAM198 protein Fam20C PF06702.12 PIK37186.1 - 3.8e-60 203.4 0.1 4.8e-60 203.1 0.1 1.1 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 RRP7 PF12923.7 PIK37187.1 - 2.2e-20 72.9 12.8 2.2e-20 72.9 12.8 1.8 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 PIK37187.1 - 7.8e-07 29.0 3.5 8.5e-07 28.9 0.0 2.4 1 1 1 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 PIK37187.1 - 9.3e-06 25.4 0.1 7.3e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAF20 PF17052.5 PIK37187.1 - 0.0042 17.3 4.2 0.0081 16.3 4.2 1.5 1 1 0 1 1 1 1 Cap associated factor Jnk-SapK_ap_N PF09744.9 PIK37187.1 - 0.05 13.8 7.0 0.028 14.6 4.5 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RRM_7 PF16367.5 PIK37187.1 - 0.061 13.5 0.4 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif GyrB_insert PF18053.1 PIK37187.1 - 0.079 12.8 3.9 0.39 10.6 0.1 2.3 1 1 1 2 2 2 0 DNA gyrase B subunit insert domain DUF4407 PF14362.6 PIK37187.1 - 1 8.6 7.1 1.5 8.1 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4507 PF14964.6 PIK37188.1 - 1.5e-51 175.5 7.0 1.7e-51 175.2 7.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) Chromo PF00385.24 PIK37189.1 - 5.2e-13 48.7 0.4 1.5e-12 47.2 0.1 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.3 PIK37189.1 - 2.7e-08 33.4 0.6 5.9e-08 32.3 0.6 1.6 1 0 0 1 1 1 1 CBX family C-terminal motif Tudor-knot PF11717.8 PIK37189.1 - 0.06 13.2 0.1 0.19 11.6 0.1 1.9 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain CBX7_C PF17218.3 PIK37190.1 - 3.8e-10 39.3 2.3 1e-09 37.9 2.3 1.7 1 0 0 1 1 1 1 CBX family C-terminal motif CDC45 PF02724.14 PIK37190.1 - 0.2 9.9 13.3 0.25 9.6 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 PIK37190.1 - 7.4 5.5 11.2 11 4.9 11.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Nucleopor_Nup85 PF07575.13 PIK37191.1 - 2.9e-159 531.3 16.2 3.3e-159 531.1 16.2 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin TPR_19 PF14559.6 PIK37191.1 - 0.13 12.8 1.8 8.8 6.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat V-set PF07686.17 PIK37192.1 - 0.0052 16.9 0.0 0.0067 16.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF913 PF06025.12 PIK37193.1 - 9.3e-05 21.6 1.4 0.0017 17.4 0.9 2.8 1 1 0 2 2 2 1 Domain of Unknown Function (DUF913) CSTF2_hinge PF14327.6 PIK37193.1 - 0.21 12.1 2.2 0.9 10.0 0.1 2.8 3 0 0 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 HEAT PF02985.22 PIK37193.1 - 0.9 10.0 14.2 67 4.2 0.0 7.3 8 0 0 8 8 8 0 HEAT repeat Pkinase PF00069.25 PIK37194.1 - 3.5e-45 154.4 0.0 5.1e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37194.1 - 2e-19 69.9 0.0 1e-17 64.3 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK37194.1 - 0.075 12.3 0.0 1 8.6 0.0 2.1 1 1 0 1 1 1 0 Kinase-like 2-Hacid_dh_C PF02826.19 PIK37196.1 - 1.1e-57 194.3 0.0 1.4e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK37196.1 - 3.3e-28 98.0 0.0 4.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 PIK37196.1 - 8.7e-05 23.0 0.0 0.00016 22.2 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 PIK37196.1 - 0.00017 21.8 0.0 0.00027 21.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 PIK37196.1 - 0.0088 16.1 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 PIK37196.1 - 0.057 13.0 0.0 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPGT PF00201.18 PIK37197.1 - 2.6e-60 204.7 0.0 2.9e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK37197.1 - 0.0013 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LIM PF00412.22 PIK37198.1 - 2.3e-32 111.0 21.1 1.3e-16 60.5 6.4 2.5 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 PIK37198.1 - 5.7e-11 42.1 0.4 1.1e-10 41.2 0.4 1.4 1 0 0 1 1 1 1 Homeodomain Furin-like_2 PF15913.5 PIK37198.1 - 0.02 15.0 7.9 0.02 15.0 7.9 1.8 1 1 0 1 1 1 0 Furin-like repeat, cysteine-rich Vps39_2 PF10367.9 PIK37198.1 - 7.1 7.1 8.5 2.7 8.5 2.7 2.9 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 2 SGS PF05002.15 PIK37200.1 - 6.6e-05 22.9 0.2 9.3e-05 22.5 0.2 1.2 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.11 PIK37201.1 - 1.6e-08 34.7 1.4 2.1e-08 34.3 1.4 1.2 1 0 0 1 1 1 1 Siah interacting protein, N terminal CS PF04969.16 PIK37201.1 - 6.7e-06 27.0 0.1 1.6e-05 25.8 0.1 1.6 1 0 0 1 1 1 1 CS domain PI3K_1B_p101 PF10486.9 PIK37201.1 - 0.043 11.6 0.0 0.044 11.6 0.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ZapD PF07072.11 PIK37201.1 - 0.069 12.9 0.2 0.084 12.6 0.2 1.1 1 0 0 1 1 1 0 Cell division protein DUF202 PF02656.15 PIK37202.1 - 3.1 8.3 13.7 0.2 12.1 0.6 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF202) FAD_SOX PF18371.1 PIK37204.1 - 4.9e-28 97.5 0.0 2.7e-26 91.9 0.0 2.5 2 0 0 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 PIK37204.1 - 1.1e-22 80.4 0.0 1e-21 77.3 0.1 2.3 2 0 0 2 2 2 1 Erv1 / Alr family QSOX_Trx1 PF18108.1 PIK37204.1 - 3.2e-07 30.5 0.0 6.7e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 QSOX Trx-like domain DUF1418 PF07214.12 PIK37204.1 - 0.076 12.9 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) NiFe-hyd_HybE PF11939.8 PIK37205.1 - 0.0074 16.2 1.1 0.0081 16.1 0.4 1.7 1 1 1 2 2 2 1 [NiFe]-hydrogenase assembly, chaperone, HybE 7tm_1 PF00001.21 PIK37207.1 - 1.3e-09 37.8 3.8 1.8e-09 37.3 3.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4133 PF13571.6 PIK37207.1 - 3 8.3 6.8 2.6 8.5 3.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4133) 7tm_1 PF00001.21 PIK37208.1 - 4.9e-19 68.7 9.6 5.6e-19 68.5 9.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YWFCY PF14293.6 PIK37208.1 - 0.032 14.5 2.3 0.074 13.4 1.8 1.9 1 1 0 1 1 1 0 YWFCY protein Form-deh_trans PF09163.11 PIK37208.1 - 0.084 12.7 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane DUF5337 PF17272.2 PIK37208.1 - 0.86 9.5 0.1 0.86 9.5 0.1 2.8 4 0 0 4 4 4 0 Family of unknown function (DUF5337) MRAP PF15183.6 PIK37208.1 - 1.9 8.5 6.7 0.3 11.1 0.9 2.3 1 1 1 2 2 2 0 Melanocortin-2 receptor accessory protein family 7tm_1 PF00001.21 PIK37209.1 - 3.2e-19 69.3 3.3 5.1e-19 68.6 3.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) IgGFc_binding PF17517.2 PIK37210.1 - 3.7e-29 101.9 3.8 1.3e-28 100.1 3.1 1.9 1 1 1 2 2 2 1 IgGFc binding protein ING PF12998.7 PIK37211.1 - 1.4e-14 54.5 0.1 2.7e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 PIK37211.1 - 0.0067 16.3 1.6 0.011 15.6 1.6 1.4 1 0 0 1 1 1 1 PHD-finger DUF2076 PF09849.9 PIK37211.1 - 0.0069 16.5 0.2 0.01 15.9 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) zf-HC5HC2H PF13771.6 PIK37211.1 - 0.031 14.5 0.1 0.06 13.6 0.1 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Folliculin PF11704.8 PIK37211.1 - 0.064 13.1 0.4 0.092 12.6 0.4 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Casc1 PF12366.8 PIK37211.1 - 0.24 10.9 1.4 0.36 10.3 1.4 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Rer1 PF03248.13 PIK37212.1 - 9e-52 175.3 2.1 1.3e-51 174.7 2.1 1.2 1 0 0 1 1 1 1 Rer1 family EamA PF00892.20 PIK37213.1 - 1.7e-09 38.0 20.4 2.5e-05 24.5 2.4 2.8 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 PIK37213.1 - 2e-05 23.9 0.1 2e-05 23.9 0.1 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter SLC35F PF06027.12 PIK37213.1 - 0.00011 21.8 9.3 0.0019 17.8 9.2 2.0 1 1 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 PIK37213.1 - 0.00012 21.2 9.5 0.0011 17.9 3.0 2.1 1 1 1 2 2 2 2 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 PIK37213.1 - 0.0077 15.6 5.8 0.012 15.0 5.8 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF4131 PF13567.6 PIK37213.1 - 0.014 15.1 0.1 0.014 15.1 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) UAA PF08449.11 PIK37213.1 - 0.018 14.3 8.2 0.035 13.3 8.2 1.6 1 1 0 1 1 1 0 UAA transporter family Mg_trans_NIPA PF05653.14 PIK37213.1 - 0.026 13.6 7.8 0.041 13.0 7.8 1.2 1 0 0 1 1 1 0 Magnesium transporter NIPA TIM PF00121.18 PIK37214.1 - 5.1e-65 219.2 1.4 6.3e-54 182.9 0.2 2.0 1 1 1 2 2 2 2 Triosephosphate isomerase Gelsolin PF00626.22 PIK37215.1 - 4.5e-10 39.3 0.1 7.7e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Gelsolin repeat Sugar_tr PF00083.24 PIK37216.1 - 2e-102 343.4 13.8 2.4e-102 343.1 13.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK37216.1 - 5.7e-12 45.2 22.1 4.5e-11 42.3 16.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 PIK37216.1 - 0.47 10.7 7.1 3.8 7.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Sugar_tr PF00083.24 PIK37217.1 - 2.3e-56 191.6 12.9 2.7e-56 191.4 12.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK37217.1 - 4.5e-07 29.1 12.7 5.2e-07 28.9 12.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily COX2-transmemb PF09125.10 PIK37217.1 - 1.1 9.1 7.1 0.076 12.8 1.5 1.9 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane Sugar_tr PF00083.24 PIK37218.1 - 2.9e-53 181.4 5.6 3.5e-53 181.1 5.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK37218.1 - 2.8e-15 56.1 8.5 3.5e-15 55.8 8.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Exo_endo_phos PF03372.23 PIK37219.1 - 8.5e-08 32.0 0.0 1.5e-07 31.2 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK37219.1 - 0.00036 20.4 0.1 0.0012 18.7 0.0 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK37220.1 - 3.1e-24 85.7 0.3 1.8e-23 83.3 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 PIK37222.1 - 7.2e-11 41.6 1.9 7.8e-11 41.5 1.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily LrgB PF04172.16 PIK37222.1 - 0.0077 15.8 0.9 0.014 14.9 0.9 1.5 1 1 0 1 1 1 1 LrgB-like family Deltameth_res PF16020.5 PIK37222.1 - 0.28 11.1 2.8 0.59 10.0 0.1 2.4 2 0 0 2 2 2 0 Deltamethrin resistance Ion_trans_2 PF07885.16 PIK37224.1 - 2.7e-23 81.7 8.2 1.7e-14 53.5 1.0 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 PIK37224.1 - 4.6e-05 22.8 2.7 0.0022 17.2 0.5 2.1 2 0 0 2 2 2 2 Ion transport protein Pneumo_att_G PF05539.11 PIK37224.1 - 0.037 13.6 2.6 0.05 13.2 2.6 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF4834 PF16118.5 PIK37224.1 - 0.11 13.4 0.3 0.11 13.4 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) LapA_dom PF06305.11 PIK37224.1 - 0.12 12.2 0.5 17 5.3 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Consortin_C PF15281.6 PIK37224.1 - 0.19 11.7 0.0 0.19 11.7 0.0 2.8 2 2 2 4 4 4 0 Consortin C-terminus LIM PF00412.22 PIK37225.1 - 7.7e-14 51.7 4.2 7.7e-14 51.7 4.2 2.8 3 0 0 3 3 3 1 LIM domain zf-met PF12874.7 PIK37225.1 - 0.14 12.6 3.2 3.9 8.0 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RNA_pol_N PF01194.17 PIK37225.1 - 0.15 12.4 1.5 0.55 10.6 0.0 2.3 2 0 0 2 2 2 0 RNA polymerases N / 8 kDa subunit zinc_ribbon_4 PF13717.6 PIK37225.1 - 0.55 10.2 10.6 1.8 8.6 0.0 4.0 4 0 0 4 4 4 0 zinc-ribbon domain zf-RING_UBOX PF13445.6 PIK37228.1 - 5.7e-09 35.9 7.1 5.7e-09 35.9 7.1 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK37228.1 - 6e-09 35.6 8.9 6e-09 35.6 8.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK37228.1 - 3.3e-07 30.0 9.7 3.3e-07 30.0 9.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK37228.1 - 5.5e-07 29.8 8.8 5.5e-07 29.8 8.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK37228.1 - 1e-06 28.8 15.3 1.6e-06 28.2 9.2 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK37228.1 - 0.00018 21.4 8.5 0.00018 21.4 8.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK37228.1 - 0.00021 21.1 14.0 0.00021 21.1 14.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FBPase PF00316.20 PIK37228.1 - 0.022 14.2 0.6 0.031 13.7 0.6 1.2 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain CdvA PF18822.1 PIK37228.1 - 0.072 12.9 11.8 0.28 11.0 3.7 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Anti-TRAP PF15777.5 PIK37228.1 - 0.27 11.2 4.4 0.69 9.9 4.4 1.8 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Prok-RING_4 PF14447.6 PIK37228.1 - 0.4 10.6 19.6 0.044 13.6 14.3 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK37228.1 - 1 9.2 10.2 0.34 10.7 3.3 2.9 2 0 0 2 2 2 0 RING-like zinc finger PEARLI-4 PF05278.12 PIK37228.1 - 3.9 7.0 12.9 0.47 10.0 8.3 1.6 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) UPF0242 PF06785.11 PIK37228.1 - 4.9 7.2 12.6 9.3 6.3 12.6 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RVT_1 PF00078.27 PIK37229.1 - 6.3e-40 137.0 0.2 7.4e-40 136.8 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Bac_A_amyl_C PF18612.1 PIK37230.1 - 0.011 15.5 0.1 0.18 11.6 0.0 2.7 3 0 0 3 3 3 0 Bacterial Alpha amylase C-terminal domain DWNN PF08783.11 PIK37230.1 - 0.12 12.6 0.0 0.41 11.0 0.0 1.9 1 0 0 1 1 1 0 DWNN domain Peptidase_C48 PF02902.19 PIK37231.1 - 1.1e-15 58.1 0.8 1.9e-15 57.3 0.7 1.4 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PHD PF00628.29 PIK37231.1 - 0.023 14.6 8.8 0.046 13.6 8.8 1.5 1 0 0 1 1 1 0 PHD-finger FYVE_2 PF02318.16 PIK37231.1 - 0.15 12.2 6.3 2 8.7 6.3 2.1 1 1 0 1 1 1 0 FYVE-type zinc finger THAP PF05485.12 PIK37234.1 - 2.2e-11 44.5 0.1 6.3e-11 43.1 0.1 1.8 1 0 0 1 1 1 1 THAP domain DDE_Tnp_ISL3 PF01610.17 PIK37234.1 - 0.014 15.1 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Transposase zf-CCHC_2 PF13696.6 PIK37234.1 - 0.015 15.1 2.9 0.046 13.5 2.9 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 PIK37234.1 - 0.024 14.7 1.3 0.024 14.7 1.3 2.2 2 0 0 2 2 2 0 Zinc knuckle MULE PF10551.9 PIK37234.1 - 0.037 14.4 0.0 0.078 13.4 0.0 1.5 1 0 0 1 1 1 0 MULE transposase domain zf-CCHC_6 PF15288.6 PIK37234.1 - 0.081 12.8 0.6 0.3 10.9 0.6 2.1 1 0 0 1 1 1 0 Zinc knuckle DDE_1 PF03184.19 PIK37236.1 - 2.2e-21 76.3 0.0 9.3e-21 74.3 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.16 PIK37236.1 - 1.8e-08 34.0 0.0 3.4e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain PHD PF00628.29 PIK37236.1 - 1.3e-06 28.2 9.6 2.9e-06 27.1 9.6 1.6 1 0 0 1 1 1 1 PHD-finger HTH_Tnp_Tc5 PF03221.16 PIK37236.1 - 3.3e-05 23.8 0.0 8.5e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Cupin_8 PF13621.6 PIK37236.1 - 0.012 15.3 3.2 0.022 14.5 3.2 1.4 1 0 0 1 1 1 0 Cupin-like domain C1_1 PF00130.22 PIK37236.1 - 0.024 14.5 1.2 0.024 14.5 1.2 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 PIK37236.1 - 0.056 13.4 1.0 0.14 12.2 1.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 PIK37236.1 - 0.56 9.8 4.9 1.7 8.3 4.9 1.9 1 1 0 1 1 1 0 PHD-finger PdaC PF13739.6 PIK37236.1 - 1.5 9.8 5.2 3.9 8.5 5.2 1.7 1 0 0 1 1 1 0 Deacetylase PdaC Zn-ribbon_8 PF09723.10 PIK37236.1 - 1.6 8.9 7.5 0.14 12.3 1.7 2.3 2 0 0 2 2 2 0 Zinc ribbon domain zf-HC5HC2H PF13771.6 PIK37236.1 - 3.7 7.9 7.5 0.42 10.9 1.9 2.3 2 0 0 2 2 2 0 PHD-like zinc-binding domain MTHFR_C PF12225.8 PIK37238.1 - 0.038 13.6 0.3 0.063 12.9 0.3 1.3 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal DDE_Tnp_ISAZ013 PF07592.11 PIK37239.1 - 0.0025 16.9 0.4 0.18 10.7 0.1 2.1 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain Integrase_H2C2 PF17921.1 PIK37240.1 - 1.9e-13 50.3 0.6 3.3e-13 49.5 0.6 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK37240.1 - 9e-09 35.6 0.0 1.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain GFO_IDH_MocA_C PF02894.17 PIK37241.1 - 0.077 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain zf-CCHC PF00098.23 PIK37243.1 - 9.9e-07 28.6 16.2 0.00073 19.5 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37243.1 - 0.00093 19.0 8.2 0.11 12.3 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37243.1 - 0.025 14.4 0.2 0.025 14.4 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37243.1 - 0.025 14.3 0.8 0.025 14.3 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK37243.1 - 0.047 13.4 11.1 5.5 6.8 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK37243.1 - 0.09 12.8 16.5 0.27 11.2 1.2 3.5 2 1 2 4 4 4 0 Zinc knuckle Cation_efflux PF01545.21 PIK37244.1 - 1.2e-09 38.2 18.4 1.9e-08 34.3 18.4 2.0 1 1 0 1 1 1 1 Cation efflux family DUF2417 PF10329.9 PIK37244.1 - 0.036 13.5 0.7 0.054 12.9 0.3 1.5 1 1 0 1 1 1 0 Region of unknown function (DUF2417) DUF3367 PF11847.8 PIK37244.1 - 0.18 9.6 0.0 0.18 9.6 0.0 1.3 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase DUF2207 PF09972.9 PIK37244.1 - 2.2 6.9 7.6 15 4.2 7.3 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Presenilin PF01080.17 PIK37244.1 - 5.2 5.7 9.8 0.72 8.6 5.2 1.8 1 1 1 2 2 2 0 Presenilin SUR7 PF06687.12 PIK37244.1 - 7.4 6.1 14.5 1.2e+02 2.1 14.5 2.3 1 1 0 1 1 1 0 SUR7/PalI family Laminin_G_3 PF13385.6 PIK37245.1 - 0.0011 19.1 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Collagen PF01391.18 PIK37246.1 - 7.1e-85 278.7 377.8 3.8e-09 36.2 24.3 15.4 6 4 7 13 13 13 13 Collagen triple helix repeat (20 copies) Endostatin PF06482.11 PIK37246.1 - 1.7e-79 267.6 0.0 2.8e-79 266.9 0.0 1.3 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin Glyco_transf_10 PF00852.19 PIK37247.1 - 1.6e-48 164.8 0.8 2.3e-48 164.2 0.8 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK37247.1 - 4e-09 36.9 0.5 8.3e-09 35.9 0.5 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Amnionless PF14828.6 PIK37248.1 - 1.4e-75 254.9 0.0 3.1e-75 253.7 0.0 1.5 1 1 0 1 1 1 1 Amnionless LRR19-TM PF15176.6 PIK37248.1 - 0.16 12.0 0.0 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain VWC PF00093.18 PIK37248.1 - 0.53 10.7 6.8 1.4 9.3 6.8 1.7 1 0 0 1 1 1 0 von Willebrand factor type C domain FtsJ PF01728.19 PIK37249.1 - 3.8e-34 118.3 0.0 8.1e-34 117.3 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 PIK37249.1 - 4.9e-13 48.8 3.8 7.4e-13 48.2 3.0 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 PIK37249.1 - 6.6e-05 22.9 1.0 0.00018 21.5 1.0 1.8 1 0 0 1 1 1 1 G-patch domain WW PF00397.26 PIK37249.1 - 0.00023 21.2 0.2 0.0084 16.2 0.0 2.6 2 0 0 2 2 2 1 WW domain MCM PF00493.23 PIK37250.1 - 3.2e-89 297.9 0.0 4.6e-89 297.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK37250.1 - 1.5e-25 89.5 1.4 2.5e-25 88.7 1.4 1.3 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 PIK37250.1 - 5.1e-09 35.8 0.0 6.1e-06 25.8 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK37250.1 - 1.3e-06 28.4 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK37250.1 - 6.9e-05 22.7 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM_lid PF17855.1 PIK37250.1 - 0.0091 16.4 0.2 0.02 15.3 0.2 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_16 PF13191.6 PIK37250.1 - 0.027 14.9 0.5 0.12 12.8 0.0 2.2 2 1 1 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.26 PIK37250.1 - 0.067 12.9 0.1 0.39 10.4 0.1 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 PIK37250.1 - 0.076 12.9 0.1 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 PIK37250.1 - 0.099 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA PF00004.29 PIK37250.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rap_GAP PF02145.15 PIK37251.1 - 0.0031 17.1 0.0 1.4 8.4 0.0 2.8 2 1 0 2 2 2 2 Rap/ran-GAP TPR_1 PF00515.28 PIK37252.1 - 2.8e-14 52.2 23.1 0.00061 19.5 0.9 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK37252.1 - 2.6e-13 49.0 26.1 0.0038 17.2 0.2 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK37252.1 - 3e-13 48.9 20.3 0.013 15.7 0.1 6.9 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK37252.1 - 2e-12 46.8 3.0 0.1 13.5 0.2 6.9 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK37252.1 - 9.5e-10 38.0 3.9 0.00044 19.9 0.5 5.1 5 1 1 6 6 4 2 TPR repeat TPR_19 PF14559.6 PIK37252.1 - 6.5e-08 33.0 6.8 0.023 15.2 0.2 5.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK37252.1 - 1.7e-07 31.8 4.4 0.00028 21.5 0.2 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK37252.1 - 4.9e-06 26.2 9.1 2.2 8.5 0.0 6.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK37252.1 - 5.1e-06 26.5 12.7 0.0089 16.3 0.7 4.9 5 1 0 5 5 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK37252.1 - 8.5e-06 26.0 13.4 0.032 14.5 2.8 6.0 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK37252.1 - 0.00027 21.0 0.7 0.068 13.3 0.0 3.8 5 0 0 5 5 4 1 Tetratricopeptide repeat PPR PF01535.20 PIK37252.1 - 0.026 14.8 5.2 8.3 6.9 0.0 4.6 4 1 1 5 5 5 0 PPR repeat BTAD PF03704.17 PIK37252.1 - 0.029 14.8 0.6 0.35 11.3 0.4 2.7 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 PIK37252.1 - 0.039 14.6 10.1 9.3 7.1 0.2 5.8 7 1 0 7 7 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK37252.1 - 0.053 13.0 6.0 5.8 6.5 0.1 4.4 4 0 0 4 4 4 0 SHNi-TPR TPR_15 PF13429.6 PIK37252.1 - 0.068 12.4 6.2 0.24 10.6 0.3 3.3 1 1 1 3 3 3 0 Tetratricopeptide repeat Streptin-Immun PF11083.8 PIK37252.1 - 0.11 12.9 1.4 0.38 11.2 0.0 2.8 3 0 0 3 3 1 0 Lantibiotic streptin immunity protein Fis1_TPR_C PF14853.6 PIK37252.1 - 0.24 11.5 3.1 1.6 8.9 0.1 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 PIK37252.1 - 0.46 10.4 9.6 1 9.3 0.3 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat CENP-F_leu_zip PF10473.9 PIK37252.1 - 0.75 9.8 5.5 0.2 11.7 0.4 2.7 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ANAPC3 PF12895.7 PIK37252.1 - 1.6 9.0 21.5 1.3 9.3 2.6 4.4 3 1 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Transglut_core PF01841.19 PIK37253.1 - 0.016 15.7 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily O-FucT PF10250.9 PIK37255.1 - 2.1e-70 238.1 0.0 2.5e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase baeRF_family10 PF18854.1 PIK37255.1 - 0.18 12.0 0.2 0.57 10.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 Pkinase PF00069.25 PIK37256.1 - 8.9e-23 81.0 0.0 1.1e-22 80.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37256.1 - 4.3e-21 75.4 0.0 5.1e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 PIK37256.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 PIK37256.1 - 0.14 11.0 0.0 0.5 9.2 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain ORC4_C PF14629.6 PIK37257.1 - 1.8e-48 164.8 0.1 3.3e-48 163.9 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 PIK37257.1 - 9.3e-11 42.4 0.7 1.8e-10 41.5 0.7 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK37257.1 - 8.5e-10 39.2 0.1 1.7e-09 38.2 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK37257.1 - 6.1e-08 33.0 0.3 1.7e-07 31.6 0.2 1.8 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK37257.1 - 2.5e-05 24.3 1.4 0.00011 22.2 1.4 2.1 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 PIK37257.1 - 6.8e-05 22.9 0.1 0.00014 21.8 0.1 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 PIK37257.1 - 0.0014 19.2 0.0 0.0024 18.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 PIK37257.1 - 0.003 17.1 0.0 0.0063 16.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 PIK37257.1 - 0.0043 16.8 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.6 PIK37257.1 - 0.0089 15.6 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK37257.1 - 0.011 14.8 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 PIK37257.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TniB PF05621.11 PIK37257.1 - 0.014 14.8 0.2 0.028 13.9 0.2 1.5 1 1 0 1 1 1 0 Bacterial TniB protein Methyltransf_28 PF02636.17 PIK37257.1 - 0.016 14.8 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase AAA_21 PF13304.6 PIK37257.1 - 0.019 14.8 0.7 4.6 7.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 PIK37257.1 - 0.021 14.9 2.1 0.11 12.5 0.2 2.5 2 1 1 3 3 3 0 Helicase HerA, central domain AAA_33 PF13671.6 PIK37257.1 - 0.029 14.5 0.1 0.078 13.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain RuvB_N PF05496.12 PIK37257.1 - 0.04 13.7 0.1 0.089 12.5 0.0 1.6 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 PIK37257.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 PIK37257.1 - 0.054 13.9 0.1 0.19 12.2 0.0 2.0 2 0 0 2 2 1 0 RNA helicase Mg_chelatase PF01078.21 PIK37257.1 - 0.055 12.9 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 PIK37257.1 - 0.074 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 PIK37257.1 - 0.077 12.2 0.2 0.41 9.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 PIK37257.1 - 0.08 12.7 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 PIK37257.1 - 0.08 13.3 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK37257.1 - 0.092 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK37257.1 - 0.092 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 PIK37257.1 - 0.36 10.2 0.8 1.7 8.0 0.1 2.0 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 PIK37259.1 - 1.3e-10 41.4 0.0 2.3e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK37259.1 - 0.00011 21.9 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK37259.1 - 0.074 12.1 0.0 3 6.8 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein ATPase PF06745.13 PIK37259.1 - 0.15 11.4 0.0 0.49 9.7 0.0 1.7 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 PIK37259.1 - 0.21 10.8 0.0 5.1 6.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) START PF01852.19 PIK37260.1 - 8.2e-15 54.8 0.0 9.7e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 START domain START PF01852.19 PIK37261.1 - 6.9e-15 55.0 0.0 8.6e-15 54.7 0.0 1.0 1 0 0 1 1 1 1 START domain START PF01852.19 PIK37262.1 - 1.5e-23 83.3 0.0 2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 START domain Vps5 PF09325.10 PIK37263.1 - 3e-83 279.0 22.0 5.7e-83 278.1 22.0 1.5 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 PIK37263.1 - 4.7e-24 84.5 0.3 1.7e-23 82.8 0.0 2.1 2 0 0 2 2 1 1 PX domain BAR_3_WASP_bdg PF10456.9 PIK37263.1 - 1.4e-06 27.9 9.5 1.4e-06 27.9 9.5 3.1 2 1 0 2 2 1 1 WASP-binding domain of Sorting nexin protein BAR_3 PF16746.5 PIK37263.1 - 0.00091 19.0 14.3 0.0012 18.6 8.8 2.4 1 1 1 2 2 2 1 BAR domain of APPL family BLOC1_2 PF10046.9 PIK37263.1 - 0.0072 16.6 0.9 0.0072 16.6 0.9 3.6 2 2 1 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 GrpE PF01025.19 PIK37263.1 - 0.009 15.7 4.7 0.009 15.7 4.7 3.7 2 1 1 4 4 4 1 GrpE Arfaptin PF06456.13 PIK37263.1 - 0.018 14.6 13.6 0.066 12.8 13.6 2.0 1 1 0 1 1 1 0 Arfaptin-like domain DUF4349 PF14257.6 PIK37263.1 - 0.21 11.0 12.6 1.8 7.9 4.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) T2SSF PF00482.23 PIK37263.1 - 0.63 10.0 3.6 3.9 7.4 1.3 2.5 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Allexi_40kDa PF05549.11 PIK37263.1 - 0.64 9.5 9.7 0.083 12.4 0.9 2.6 1 1 2 3 3 3 0 Allexivirus 40kDa protein MCPsignal PF00015.21 PIK37263.1 - 1.4 8.7 7.0 0.75 9.6 0.7 2.5 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1835 PF08874.10 PIK37263.1 - 1.4 9.1 10.3 0.25 11.6 2.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1835) Sec34 PF04136.15 PIK37263.1 - 2.2 8.2 11.7 0.62 9.9 3.2 3.2 1 1 2 3 3 3 0 Sec34-like family PilO PF04350.13 PIK37263.1 - 2.3 8.4 9.2 0.26 11.5 1.4 2.5 2 0 0 2 2 2 0 Pilus assembly protein, PilO FlaC_arch PF05377.11 PIK37263.1 - 2.7 8.5 8.2 14 6.2 0.2 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 PIK37263.1 - 3 7.9 5.5 14 5.7 0.3 2.7 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF501 PF04417.12 PIK37263.1 - 4.5 7.1 8.1 4.6 7.0 1.0 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF501) Syntaxin-6_N PF09177.11 PIK37263.1 - 5 7.7 14.1 7.2 7.2 3.0 3.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 PIK37263.1 - 5.7 7.3 7.5 4 7.8 2.7 3.0 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Plasmid_RAQPRD PF09686.10 PIK37263.1 - 6.7 7.0 6.6 12 6.2 0.4 4.0 5 0 0 5 5 5 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Exonuc_VII_L PF02601.15 PIK37263.1 - 8.1 5.9 20.9 1.4 8.4 6.0 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit TMPIT PF07851.13 PIK37263.1 - 9.3 5.4 16.9 3.1 7.0 4.0 2.4 1 1 0 2 2 2 0 TMPIT-like protein DUF1664 PF07889.12 PIK37263.1 - 9.3 6.3 11.0 4.3 7.4 2.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FBPase PF00316.20 PIK37264.1 - 9.3e-75 250.3 0.1 1.2e-74 249.9 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 PIK37264.1 - 0.0016 18.0 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family DUF5082 PF16888.5 PIK37265.1 - 0.00042 20.6 15.0 0.0013 19.0 3.8 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF5082) Spc7 PF08317.11 PIK37265.1 - 0.017 14.1 26.5 0.1 11.5 26.5 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 PIK37265.1 - 0.02 14.3 21.9 0.025 13.9 21.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HOOK PF05622.12 PIK37265.1 - 0.021 13.0 23.6 0.025 12.8 23.6 1.1 1 0 0 1 1 1 0 HOOK protein PRKG1_interact PF15898.5 PIK37265.1 - 0.022 15.6 26.6 0.19 12.7 5.5 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain GAS PF13851.6 PIK37265.1 - 0.059 12.7 21.9 0.086 12.2 21.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding WXG100 PF06013.12 PIK37265.1 - 0.14 12.4 6.1 1.2 9.5 0.6 2.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Fez1 PF06818.15 PIK37265.1 - 0.16 12.4 23.7 0.23 11.9 23.7 1.3 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 PIK37265.1 - 0.24 10.4 23.1 0.28 10.2 20.7 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 PIK37265.1 - 0.31 11.2 14.4 0.96 9.7 9.6 2.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Prefoldin_2 PF01920.20 PIK37265.1 - 0.38 10.7 24.5 0.65 10.0 10.3 3.0 1 1 2 3 3 3 0 Prefoldin subunit Seryl_tRNA_N PF02403.22 PIK37265.1 - 0.4 10.9 20.5 0.14 12.4 15.4 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ALMT PF11744.8 PIK37265.1 - 0.89 8.3 8.7 1.1 8.0 8.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Synaptobrevin PF00957.21 PIK37265.1 - 0.94 9.3 4.2 3.2 7.6 4.2 1.9 1 0 0 1 1 1 0 Synaptobrevin GREB1 PF15782.5 PIK37265.1 - 0.94 6.5 10.9 1.1 6.3 10.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Erp_C PF06780.11 PIK37265.1 - 1.1 9.2 12.6 1.2 9.1 11.6 1.5 1 1 0 1 1 1 0 Erp protein C-terminus FlaC_arch PF05377.11 PIK37265.1 - 1.5 9.3 7.4 21 5.6 6.6 2.6 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) FapA PF03961.13 PIK37265.1 - 1.5 7.3 10.9 2.1 6.9 10.9 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A THOC7 PF05615.13 PIK37265.1 - 2.1 8.7 20.9 27 5.1 20.9 2.2 1 1 0 1 1 1 0 Tho complex subunit 7 TPR_MLP1_2 PF07926.12 PIK37265.1 - 2.5 8.2 27.0 1.1 9.4 8.3 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Methyltransf_14 PF08484.11 PIK37265.1 - 3.5 7.4 7.2 0.94 9.3 1.8 2.1 1 1 1 2 2 2 0 C-methyltransferase C-terminal domain HemX PF04375.14 PIK37265.1 - 3.6 6.8 20.6 0.1 11.9 1.6 2.4 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Prominin PF05478.11 PIK37265.1 - 3.6 5.4 7.6 5.4 4.8 7.6 1.3 1 0 0 1 1 1 0 Prominin HIP1_clath_bdg PF16515.5 PIK37265.1 - 5.6 7.7 29.0 0.74 10.5 12.5 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 PIK37265.1 - 5.6 7.5 32.8 0.17 12.5 21.8 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region Fzo_mitofusin PF04799.13 PIK37265.1 - 5.8 6.4 8.4 10 5.6 8.4 1.5 1 1 0 1 1 1 0 fzo-like conserved region DUF4551 PF15087.6 PIK37265.1 - 7.4 5.3 13.0 9 5.0 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) UDPGT PF00201.18 PIK37266.1 - 6.6e-51 173.6 1.5 4.9e-50 170.8 1.5 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK37266.1 - 1e-13 51.6 0.0 1.5e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Gemini_mov PF01708.16 PIK37266.1 - 0.016 15.0 0.1 0.026 14.3 0.1 1.3 1 0 0 1 1 1 0 Geminivirus putative movement protein UDPGT PF00201.18 PIK37267.1 - 3.5e-117 392.3 0.0 3.9e-117 392.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK37267.1 - 5.1e-11 42.8 0.2 2.8e-10 40.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain DUF4407 PF14362.6 PIK37269.1 - 0.076 12.4 4.3 0.06 12.7 1.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) KxDL PF10241.9 PIK37269.1 - 0.16 12.2 5.3 8.1 6.8 0.1 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein YabA PF06156.13 PIK37269.1 - 0.17 12.5 10.0 1.3 9.7 0.1 2.5 3 0 0 3 3 3 0 Initiation control protein YabA PI3K_P85_iSH2 PF16454.5 PIK37269.1 - 0.37 10.4 12.5 2 8.0 0.1 2.5 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DivIC PF04977.15 PIK37269.1 - 2.1 8.2 10.2 0.15 11.9 0.7 3.0 2 1 0 2 2 2 0 Septum formation initiator Spc24 PF08286.11 PIK37269.1 - 3.1 8.1 10.7 0.82 9.9 0.2 2.8 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 UPF0242 PF06785.11 PIK37269.1 - 4.8 7.2 14.1 2.9 7.9 8.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Occludin_ELL PF07303.13 PIK37269.1 - 7.5 7.4 10.6 0.62 10.8 1.5 2.8 3 0 0 3 3 3 0 Occludin homology domain APG6_N PF17675.1 PIK37269.1 - 8.6 6.9 19.2 3.3 8.2 0.2 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF1823 PF08853.11 PIK37272.1 - 0.064 13.4 0.1 0.087 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1823) DUF5567 PF17722.1 PIK37273.1 - 5.2e-12 46.2 6.7 2e-10 40.9 0.4 2.5 2 0 0 2 2 2 2 Family of unknown function (DUF5567) Lpp-LpqN PF10738.9 PIK37273.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Probable lipoprotein LpqN Ank_4 PF13637.6 PIK37274.1 - 4.1e-38 129.3 6.0 2.2e-06 28.1 0.0 8.0 7 3 3 10 10 10 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK37274.1 - 1.2e-37 128.3 12.0 2.8e-09 37.4 0.1 6.0 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK37274.1 - 1.9e-32 110.9 12.5 5.2e-08 33.0 0.2 7.7 7 1 1 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK37274.1 - 2.3e-26 88.9 7.4 3.4e-06 27.0 0.1 9.5 9 0 0 9 9 9 4 Ankyrin repeat Ank PF00023.30 PIK37274.1 - 1.8e-25 88.2 9.7 0.00015 22.1 0.0 7.9 8 0 0 8 8 8 5 Ankyrin repeat Exog_C PF18026.1 PIK37274.1 - 0.058 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain NuA4 PF09340.10 PIK37274.1 - 0.12 12.3 0.9 0.28 11.1 0.9 1.7 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 rhaM PF05336.13 PIK37274.1 - 0.12 12.4 1.1 0.38 10.8 0.7 2.1 2 0 0 2 2 2 0 L-rhamnose mutarotase Peptidase_M54 PF07998.11 PIK37275.1 - 1.3e-07 31.8 0.0 2.3e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M54 Fibrinogen_C PF00147.18 PIK37276.1 - 1.8e-45 155.5 3.1 2.1e-45 155.2 3.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK37276.1 - 0.01 15.2 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain Ndufs5 PF10200.9 PIK37277.1 - 1.5e-10 41.2 0.0 2e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Cmc1 PF08583.10 PIK37277.1 - 0.0007 19.6 0.7 0.0011 18.9 0.7 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 PIK37277.1 - 0.0012 19.0 0.5 0.0017 18.5 0.5 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.13 PIK37277.1 - 3.5 7.9 6.4 34 4.7 6.4 2.1 1 1 0 1 1 1 0 CHCH domain EMP70 PF02990.16 PIK37278.1 - 1.8e-140 469.0 33.9 1.8e-140 469.0 33.9 2.4 2 1 0 2 2 2 1 Endomembrane protein 70 MFS_1 PF07690.16 PIK37278.1 - 6.4e-05 22.0 15.4 6.4e-05 22.0 15.4 3.2 1 1 2 3 3 3 1 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 PIK37278.1 - 7.3 6.7 0.0 7.3 6.7 0.0 5.7 4 2 2 6 6 6 0 Putative Actinobacterial Holin-X, holin superfamily III EMP70 PF02990.16 PIK37279.1 - 1e-17 64.1 0.1 1.3e-17 63.7 0.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 adh_short PF00106.25 PIK37280.1 - 4.8e-48 163.2 0.1 6.6e-48 162.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37280.1 - 4.6e-34 118.0 0.0 6.5e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK37280.1 - 1e-11 45.1 0.1 1.8e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 PIK37280.1 - 0.00095 18.6 0.0 0.0015 17.9 0.0 1.3 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 PIK37280.1 - 0.0021 17.5 0.1 0.0039 16.7 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK37280.1 - 0.0025 17.7 0.0 0.012 15.5 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Eno-Rase_NADH_b PF12242.8 PIK37280.1 - 0.021 14.6 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NusB PF01029.18 PIK37280.1 - 0.11 12.7 0.4 0.25 11.6 0.4 1.6 1 1 0 1 1 1 0 NusB family adh_short PF00106.25 PIK37281.1 - 2e-45 154.7 0.2 2.8e-45 154.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37281.1 - 6.8e-33 114.2 0.0 1.1e-32 113.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK37281.1 - 1e-10 41.8 0.0 1.5e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 PIK37281.1 - 0.00023 21.1 0.0 0.00038 20.4 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 PIK37281.1 - 0.00047 19.6 0.1 0.00079 18.9 0.0 1.4 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 PIK37281.1 - 0.0022 17.5 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 PIK37281.1 - 0.016 14.9 0.0 0.042 13.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NusB PF01029.18 PIK37281.1 - 0.049 13.9 0.2 0.11 12.8 0.2 1.5 1 1 0 1 1 1 0 NusB family DUF1788 PF08747.11 PIK37281.1 - 0.3 11.1 1.7 1.1 9.3 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1788) Fibrinogen_C PF00147.18 PIK37282.1 - 5.4e-25 88.5 0.2 8.5e-25 87.9 0.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK37282.1 - 4.7e-07 29.7 5.4 8.2e-07 28.9 1.3 2.9 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK37282.1 - 3e-05 24.1 4.0 3e-05 24.1 4.0 2.2 1 1 1 2 2 2 1 EGF domain MFS_1 PF07690.16 PIK37283.1 - 7.6e-15 54.7 5.1 1e-14 54.3 5.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF563 PF04577.14 PIK37284.1 - 4.8e-19 69.3 0.0 7.7e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) SSP160 PF06933.11 PIK37285.1 - 0.0029 15.9 7.1 0.0042 15.4 7.1 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 ArfGap PF01412.18 PIK37286.1 - 2.1e-28 98.8 0.9 2.1e-28 98.8 0.9 2.2 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf Ribonuc_L-PSP PF01042.21 PIK37287.1 - 3.5e-22 78.7 0.0 3.9e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Fibrinogen_C PF00147.18 PIK37288.1 - 2e-06 27.8 0.1 3.1e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CDC27 PF09507.10 PIK37288.1 - 0.017 14.6 0.3 0.019 14.3 0.3 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Fibrinogen_C PF00147.18 PIK37289.1 - 2.8e-28 99.2 1.3 3.3e-28 99.0 1.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK37290.1 - 1.8e-20 73.7 0.8 1.8e-20 73.7 0.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Vpu PF00558.19 PIK37293.1 - 1.4 8.8 3.6 0.96 9.3 1.7 1.6 1 1 0 1 1 1 0 Vpu protein Thionin PF00321.17 PIK37293.1 - 1.8 9.1 3.6 48 4.5 0.2 3.3 3 0 0 3 3 3 0 Plant thionin Peptidase_M2 PF01401.18 PIK37294.1 - 9.6e-176 585.7 0.2 1.1e-175 585.5 0.2 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Ras PF00071.22 PIK37296.1 - 1.2e-24 86.8 0.1 1.3e-24 86.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK37296.1 - 7.5e-10 39.1 0.0 1.1e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK37296.1 - 1.3e-08 34.5 0.0 1.7e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK37296.1 - 6.6e-05 23.0 0.1 0.0001 22.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK37296.1 - 0.00088 18.9 0.4 0.037 13.6 0.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK37296.1 - 0.022 14.7 0.1 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 PIK37296.1 - 0.11 12.1 0.2 10 5.6 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.29 PIK37297.1 - 1.2e-43 148.9 0.0 4.2e-43 147.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK37297.1 - 3.3e-28 98.3 0.0 1.1e-26 93.3 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 PIK37297.1 - 1.2e-27 95.6 7.5 1.4e-19 69.6 1.1 2.9 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 PIK37297.1 - 4.1e-10 39.5 0.0 3.5e-08 33.3 0.0 2.6 2 0 0 2 2 2 1 KH-like RNA-binding domain CMS1 PF14617.6 PIK37297.1 - 0.0004 19.8 0.0 0.0018 17.6 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit KH_2 PF07650.17 PIK37297.1 - 0.00074 19.3 0.3 0.0027 17.5 0.3 1.9 1 0 0 1 1 1 1 KH domain ResIII PF04851.15 PIK37297.1 - 0.0015 18.6 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RPAP1_N PF08621.10 PIK37297.1 - 0.0034 17.1 0.3 0.02 14.6 0.1 2.3 2 0 0 2 2 2 1 RPAP1-like, N-terminal KH_4 PF13083.6 PIK37297.1 - 0.0073 16.2 0.3 0.021 14.7 0.3 1.8 1 0 0 1 1 1 1 KH domain TA0956 PF11513.8 PIK37297.1 - 0.013 15.7 0.1 0.038 14.2 0.1 1.7 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 KH_5 PF13184.6 PIK37297.1 - 0.077 13.1 0.5 0.38 10.9 0.3 2.2 2 0 0 2 2 2 0 NusA-like KH domain gp32 PF08804.10 PIK37297.1 - 0.093 12.8 0.4 40 4.2 0.0 3.0 3 0 0 3 3 3 0 gp32 DNA binding protein like CsgF PF10614.9 PIK37297.1 - 0.13 12.5 0.6 20 5.4 0.0 3.0 3 0 0 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein Lig_chan PF00060.26 PIK37298.1 - 1.1e-26 93.4 0.2 1.2e-26 93.3 0.2 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 PIK37299.1 - 1.9e-18 66.7 0.0 5.4e-18 65.2 0.0 1.6 1 1 0 1 1 1 1 Receptor family ligand binding region RAM PF15320.6 PIK37299.1 - 0.18 12.4 0.2 0.18 12.4 0.2 2.1 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein Dimer_Tnp_hAT PF05699.14 PIK37300.1 - 1.6e-09 37.4 0.7 3.3e-09 36.4 0.7 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RT_RNaseH_2 PF17919.1 PIK37301.1 - 5e-08 32.9 0.0 8.7e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37301.1 - 2.2e-06 27.4 0.0 3.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) eIF3g PF12353.8 PIK37302.1 - 0.002 18.5 0.2 0.005 17.2 0.2 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCCH_7 PF18586.1 PIK37302.1 - 0.029 14.7 2.1 0.053 13.9 0.6 2.2 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 PNMA PF14893.6 PIK37302.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 PNMA Retrotrans_gag PF03732.17 PIK37302.1 - 0.12 12.6 0.1 0.78 10.1 0.0 2.4 2 0 0 2 2 2 0 Retrotransposon gag protein Arm-DNA-bind_4 PF14657.6 PIK37303.1 - 0.044 13.6 0.2 0.1 12.4 0.2 1.7 1 0 0 1 1 1 0 Arm DNA-binding domain iPGM_N PF06415.13 PIK37305.1 - 9.1e-74 247.5 0.0 1.4e-73 247.0 0.0 1.3 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 PIK37305.1 - 2.3e-64 217.1 0.0 2.6e-64 217.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 PIK37305.1 - 0.00024 20.6 0.0 0.00032 20.2 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK37305.1 - 0.0057 16.3 0.0 0.0093 15.6 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 PIK37305.1 - 0.064 12.2 0.0 0.15 10.9 0.0 1.5 2 0 0 2 2 2 0 Alkaline phosphatase PglZ PF08665.12 PIK37305.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 PglZ domain DUF616 PF04765.13 PIK37305.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF616) Haspin_kinase PF12330.8 PIK37306.1 - 4e-70 236.6 0.1 4e-70 236.6 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase PF00069.25 PIK37306.1 - 8.6e-09 35.1 0.0 2.9e-08 33.4 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37306.1 - 0.00034 20.0 0.0 0.00067 19.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK37306.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_6 PF13516.6 PIK37307.1 - 0.00048 20.0 12.1 2.5 8.4 0.2 6.4 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 PIK37307.1 - 0.12 12.8 26.5 0.94 10.0 0.4 7.3 5 3 3 8 8 8 0 Leucine Rich repeats (2 copies) Peptidase_M10 PF00413.24 PIK37308.1 - 2.3e-23 82.8 0.1 5.1e-23 81.7 0.1 1.6 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK37308.1 - 9.1e-22 76.8 21.9 4.7e-07 29.7 0.1 5.9 6 0 0 6 6 6 4 Hemopexin Reprolysin_4 PF13583.6 PIK37308.1 - 0.0082 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK37308.1 - 0.03 14.8 0.0 0.1 13.1 0.0 2.0 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 PIK37308.1 - 0.034 13.8 0.5 1 9.0 0.3 2.3 1 1 1 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.6 PIK37308.1 - 0.036 14.2 1.0 0.099 12.8 0.1 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12 Zincin_1 PF06262.11 PIK37308.1 - 0.1 12.7 0.1 0.36 11.0 0.1 1.9 2 0 0 2 2 2 0 Zincin-like metallopeptidase Peptidase_M50B PF13398.6 PIK37308.1 - 0.33 10.6 0.3 0.57 9.8 0.1 1.4 2 0 0 2 2 2 0 Peptidase M50B-like Sulfotransfer_2 PF03567.14 PIK37309.1 - 2.4e-46 158.7 0.3 3.1e-46 158.4 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase family FRG1 PF06229.12 PIK37310.1 - 2.5e-61 206.7 0.7 5.8e-61 205.5 0.0 1.7 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 PIK37310.1 - 3e-08 33.8 0.0 7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Fascin domain DUF1754 PF08555.10 PIK37310.1 - 0.00067 20.4 8.5 0.00067 20.4 8.5 1.8 2 0 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) Jak1_Phl PF17887.1 PIK37310.1 - 0.1 12.6 1.0 0.24 11.4 1.0 1.5 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Pox_RNA_pol PF03293.14 PIK37310.1 - 0.21 11.3 0.9 0.51 10.0 0.2 1.9 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit OHCU_decarbox PF09349.10 PIK37311.1 - 0.089 13.3 0.0 0.097 13.2 0.0 1.1 1 0 0 1 1 1 0 OHCU decarboxylase Pkinase_Tyr PF07714.17 PIK37313.1 - 4.4e-09 36.0 0.1 4.8e-09 35.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37313.1 - 4.5e-07 29.5 0.0 4.5e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37314.1 - 0.0079 15.5 0.1 0.01 15.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C9orf72-like PF15019.6 PIK37315.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 C9orf72-like protein family A2M_BRD PF07703.14 PIK37316.1 - 2.2e-24 86.4 0.0 4.3e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain TED_complement PF07678.14 PIK37317.1 - 4.2e-91 305.2 0.1 5.1e-91 305.0 0.1 1.1 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 PIK37317.1 - 0.041 13.7 1.0 0.11 12.3 0.2 2.2 2 0 0 2 2 2 0 Alpha-2-macroglobulin family Prenyltrans PF00432.21 PIK37317.1 - 0.11 12.2 0.0 0.74 9.6 0.0 2.4 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat A2M_recep PF07677.14 PIK37318.1 - 2.2e-14 53.9 0.7 3.3e-14 53.4 0.7 1.2 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain Exo_endo_phos_2 PF14529.6 PIK37319.1 - 4.6e-07 29.7 1.4 1.3e-06 28.3 0.3 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK37319.1 - 0.0001 21.9 0.0 0.00046 19.8 0.0 1.9 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK37320.1 - 2.7e-37 128.4 0.1 1e-36 126.5 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Rad60-SLD PF11976.8 PIK37322.1 - 4.3e-11 42.5 0.0 6.2e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 PIK37322.1 - 4.1e-06 26.4 0.0 6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family EGF PF00008.27 PIK37323.1 - 0.0013 19.0 11.5 0.0013 19.0 11.5 3.2 2 2 0 2 2 2 1 EGF-like domain Pox_A28 PF04584.14 PIK37323.1 - 1.4 9.2 6.5 0.83 9.8 3.4 2.0 1 1 1 2 2 2 0 Poxvirus A28 family Pribosyltran_N PF13793.6 PIK37324.1 - 2.8e-50 169.1 1.5 9.1e-49 164.2 0.1 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 PIK37324.1 - 1.2e-43 149.3 2.6 4e-36 124.8 1.0 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 PIK37324.1 - 3.3e-16 59.2 0.2 1.2e-14 54.2 0.2 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 PIK37324.1 - 0.0003 20.3 0.1 0.0007 19.1 0.1 1.6 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Lar_N PF09861.9 PIK37324.1 - 0.079 12.1 0.9 0.21 10.8 0.0 2.1 3 0 0 3 3 3 0 Lactate racemase N-terminal domain zf-C2H2 PF00096.26 PIK37325.1 - 4e-21 74.2 50.9 9.7e-06 25.8 3.6 7.9 7 1 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK37325.1 - 2e-14 53.0 43.5 0.0029 18.3 3.2 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK37325.1 - 2.3e-06 27.8 51.8 0.0011 19.3 1.3 7.8 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_8 PF15909.5 PIK37325.1 - 0.0022 18.2 24.9 1 9.7 9.8 4.8 1 1 3 4 4 4 3 C2H2-type zinc ribbon CpXC PF14353.6 PIK37325.1 - 0.011 15.8 6.5 1.4 8.9 2.5 3.0 1 1 1 2 2 2 0 CpXC protein Zn-C2H2_12 PF18112.1 PIK37325.1 - 0.012 16.1 5.3 0.8 10.2 0.0 3.7 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain FOXP-CC PF16159.5 PIK37325.1 - 1.2 9.8 30.3 1.3 9.7 4.5 6.2 1 1 4 6 6 6 0 FOXP coiled-coil domain Proteasom_PSMB PF10508.9 PIK37326.1 - 9.3e-105 351.0 0.4 1e-104 350.8 0.4 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.20 PIK37326.1 - 5.4e-07 28.5 0.1 3.3e-06 25.9 0.0 1.9 1 1 1 2 2 2 1 Adaptin N terminal region RTP1_C1 PF10363.9 PIK37326.1 - 0.00013 22.2 2.7 0.017 15.3 0.9 4.0 3 2 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 IFRD PF05004.13 PIK37326.1 - 0.00076 18.7 0.6 0.0027 16.9 0.2 2.0 1 1 1 2 2 2 1 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 PIK37326.1 - 0.0011 19.3 3.5 3.5 8.1 0.2 4.4 3 2 2 5 5 5 1 HEAT repeats RTTN_N PF14726.6 PIK37326.1 - 0.0052 17.5 4.0 2 9.3 0.4 4.1 3 1 2 5 5 5 1 Rotatin, an armadillo repeat protein, centriole functioning RICTOR_M PF14666.6 PIK37326.1 - 0.024 14.4 0.1 1.5 8.6 0.0 2.7 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain UNC45-central PF11701.8 PIK37326.1 - 0.042 13.8 0.5 7.6 6.5 0.0 2.6 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central Cnd1 PF12717.7 PIK37326.1 - 0.12 12.5 6.6 0.79 9.7 2.7 3.1 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 PIK37326.1 - 0.46 10.4 5.9 2.1 8.2 1.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3361) Arm PF00514.23 PIK37326.1 - 1.1 9.4 5.0 45 4.3 0.2 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat PAP2 PF01569.21 PIK37327.1 - 0.0018 18.0 0.2 0.03 14.1 0.1 2.2 1 1 1 2 2 2 1 PAP2 superfamily DUF1759 PF03564.15 PIK37334.1 - 6.9e-06 26.1 0.0 2.1e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) XRCC4 PF06632.12 PIK37335.1 - 0.083 11.7 0.2 0.11 11.3 0.2 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Peptidase_A17 PF05380.13 PIK37336.1 - 8.8e-21 74.6 0.0 1.5e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase fn3 PF00041.21 PIK37337.1 - 6.6e-24 84.1 2.1 8e-09 35.7 0.0 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK37337.1 - 5.1e-05 23.8 4.3 0.091 13.3 0.3 3.8 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain zf-CCHC PF00098.23 PIK37338.1 - 2.8e-06 27.1 18.2 0.016 15.3 1.8 3.4 3 0 0 3 3 3 3 Zinc knuckle Exo_endo_phos_2 PF14529.6 PIK37338.1 - 1.7e-05 24.6 0.6 6.9e-05 22.7 0.0 2.4 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase zf-CCHC_2 PF13696.6 PIK37338.1 - 0.017 14.9 2.5 0.017 14.9 2.5 3.0 2 1 1 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37338.1 - 3.3 7.5 11.7 1.7 8.4 3.4 2.4 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK37338.1 - 3.7 7.4 16.3 0.78 9.5 1.6 3.1 1 1 2 3 3 3 0 Zinc knuckle zf-C3HC4_2 PF13923.6 PIK37338.1 - 9.4 6.2 10.6 28 4.6 10.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) fn3 PF00041.21 PIK37339.1 - 1.8e-13 50.6 0.2 3.3e-13 49.8 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK37339.1 - 0.02 15.5 0.0 0.054 14.1 0.0 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain U3snoRNP10 PF12397.8 PIK37341.1 - 0.32 11.4 4.9 0.17 12.2 0.5 2.4 2 1 1 3 3 3 0 U3 small nucleolar RNA-associated protein 10 TSP_1 PF00090.19 PIK37342.1 - 5.1e-23 81.0 166.1 8.4e-08 32.3 5.4 18.3 17 4 2 19 19 19 10 Thrombospondin type 1 domain TSP_1 PF00090.19 PIK37343.1 - 3.2e-05 24.1 2.5 3.2e-05 24.1 2.5 3.6 4 0 0 4 4 4 2 Thrombospondin type 1 domain EB PF01683.18 PIK37343.1 - 0.69 10.2 12.3 0.043 14.1 5.5 2.6 2 0 0 2 2 2 0 EB module M16C_assoc PF08367.11 PIK37344.1 - 7.5e-75 251.3 0.1 1.3e-74 250.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 PIK37344.1 - 1.6e-25 90.2 0.0 1.3e-21 77.5 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 PIK37344.1 - 1.6e-11 44.4 0.3 4.2e-09 36.5 0.0 3.3 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) DUF1743 PF08489.11 PIK37344.1 - 0.046 13.8 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) SR-25 PF10500.9 PIK37345.1 - 3.6e-07 30.0 35.5 4.6e-07 29.7 35.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MDFI PF15316.6 PIK37345.1 - 0.061 13.4 7.0 0.083 13.0 7.0 1.3 1 0 0 1 1 1 0 MyoD family inhibitor Peroxin-3 PF04882.12 PIK37345.1 - 0.14 11.1 6.4 0.14 11.2 6.4 1.0 1 0 0 1 1 1 0 Peroxin-3 CCDC106 PF15794.5 PIK37345.1 - 0.81 9.4 24.0 0.97 9.1 24.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SUZ PF12752.7 PIK37345.1 - 3.5 8.5 13.0 7.1 7.5 13.0 1.6 1 0 0 1 1 1 0 SUZ domain Herpes_pp85 PF04637.12 PIK37345.1 - 3.6 5.9 7.1 4.4 5.6 7.1 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SARAF PF06682.12 PIK37345.1 - 4.4 6.9 12.3 5.2 6.6 12.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4692 PF15763.5 PIK37345.1 - 5.4 7.4 11.3 7.7 6.9 11.3 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) TFIIF_alpha PF05793.12 PIK37345.1 - 5.6 5.4 25.9 7.2 5.1 25.9 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Menin PF05053.13 PIK37345.1 - 6.1 5.1 9.8 7 4.9 9.8 1.0 1 0 0 1 1 1 0 Menin Dehydrin PF00257.19 PIK37345.1 - 8.1 7.0 30.3 0.11 13.1 5.0 2.2 1 1 1 2 2 2 0 Dehydrin SH3_1 PF00018.28 PIK37347.1 - 3.5e-12 45.7 0.0 5.9e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain C1_1 PF00130.22 PIK37347.1 - 5.5e-10 39.0 6.6 1.2e-09 37.9 6.6 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 PIK37347.1 - 2.3e-09 36.8 0.0 4.2e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK37347.1 - 2.9e-09 36.6 0.0 5.2e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain FYVE_2 PF02318.16 PIK37347.1 - 0.014 15.6 3.9 0.014 15.6 3.9 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger C1_2 PF03107.16 PIK37347.1 - 0.1 12.9 2.7 0.26 11.6 2.7 1.7 1 0 0 1 1 1 0 C1 domain Prok-RING_1 PF14446.6 PIK37347.1 - 0.13 12.2 3.0 0.33 10.9 3.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 PIK37347.1 - 0.13 12.5 3.3 0.31 11.4 3.3 1.6 1 0 0 1 1 1 0 RING-like domain STAC2_u1 PF16664.5 PIK37347.1 - 0.3 11.6 13.6 0.042 14.3 8.8 2.2 2 1 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Sec2p PF06428.11 PIK37347.1 - 3.2 7.8 9.1 0.44 10.6 4.4 2.0 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p zf-U1 PF06220.12 PIK37348.1 - 9.9e-20 70.0 9.8 1.6e-19 69.4 9.8 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.7 PIK37348.1 - 0.75 10.3 5.1 7.9 7.0 5.1 2.3 1 1 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK37348.1 - 2.9 8.3 10.7 31 5.0 10.7 2.2 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding RVT_1 PF00078.27 PIK37349.1 - 0.0027 17.2 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF PF00008.27 PIK37351.1 - 1.2e-32 111.8 38.6 1.9e-10 40.9 3.4 4.4 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK37351.1 - 3.8e-22 78.1 42.0 5.5e-07 30.0 3.1 6.2 6 1 1 7 7 7 4 Human growth factor-like EGF EGF_CA PF07645.15 PIK37351.1 - 2.6e-17 62.7 49.1 2.9e-05 24.2 3.3 4.9 3 2 2 5 5 5 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK37351.1 - 5.6e-11 42.6 45.6 0.00018 21.8 4.6 4.3 4 0 0 4 4 4 4 EGF-like domain FXa_inhibition PF14670.6 PIK37351.1 - 1.4e-08 34.9 35.7 0.0057 16.9 3.7 4.8 3 3 1 4 4 4 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK37351.1 - 3.9e-07 30.2 36.9 0.00019 21.5 5.1 5.0 2 2 2 4 4 4 4 EGF domain Laminin_EGF PF00053.24 PIK37351.1 - 0.00043 20.4 40.9 1 9.5 8.2 4.3 1 1 3 4 4 4 3 Laminin EGF domain EGF_MSP1_1 PF12946.7 PIK37351.1 - 0.0036 17.3 7.6 0.0036 17.3 7.6 4.5 4 1 0 4 4 4 1 MSP1 EGF domain 1 EGF PF00008.27 PIK37352.1 - 2e-48 162.2 98.4 3.1e-08 33.8 9.4 7.6 7 0 0 7 7 7 7 EGF-like domain hEGF PF12661.7 PIK37352.1 - 1.1e-29 102.0 102.7 9.2e-07 29.3 4.6 9.6 11 0 0 11 11 11 7 Human growth factor-like EGF EGF_CA PF07645.15 PIK37352.1 - 2.7e-26 91.5 99.3 2.2e-07 30.9 9.7 7.4 5 2 2 7 7 7 7 Calcium-binding EGF domain EGF_2 PF07974.13 PIK37352.1 - 4.9e-11 42.8 119.4 0.0034 17.7 10.0 7.7 8 0 0 8 8 8 6 EGF-like domain EGF_3 PF12947.7 PIK37352.1 - 4.6e-05 23.5 93.2 0.00079 19.6 7.3 8.8 8 2 0 8 8 8 6 EGF domain FXa_inhibition PF14670.6 PIK37352.1 - 0.00028 21.1 86.9 0.064 13.5 9.7 7.5 3 2 4 7 7 7 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK37352.1 - 0.0037 17.2 12.8 0.015 15.2 2.1 8.2 9 2 0 9 9 9 5 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK37352.1 - 8.6 6.6 86.2 4.9 7.4 7.9 7.3 2 2 4 6 6 6 0 Laminin EGF domain Gal-3-0_sulfotr PF06990.11 PIK37355.1 - 1.8e-31 109.5 1.2 1.9e-31 109.4 1.2 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK37355.1 - 0.098 13.0 0.1 0.13 12.7 0.1 1.2 1 0 0 1 1 1 0 Sulfotransferase family LRR_8 PF13855.6 PIK37356.1 - 5.3e-42 141.4 66.0 2.4e-13 49.6 3.0 5.3 1 1 5 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 PIK37356.1 - 1.9e-12 47.2 0.2 5.6e-07 29.6 0.0 3.1 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK37356.1 - 1.7e-10 40.9 35.9 0.0011 19.3 1.0 5.7 1 1 9 10 10 10 7 Leucine Rich repeats (2 copies) ig PF00047.25 PIK37356.1 - 1.3e-05 25.2 0.0 3.7e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 PIK37356.1 - 0.00016 21.2 14.7 0.0014 18.1 0.6 3.7 1 1 3 4 4 4 2 Leucine-rich repeat Ig_3 PF13927.6 PIK37356.1 - 0.0003 21.3 0.0 0.00099 19.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK37356.1 - 0.0014 18.6 0.0 0.0032 17.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK37356.1 - 0.011 16.0 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Baculo_11_kDa PF06143.11 PIK37356.1 - 0.014 15.0 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family V-set PF07686.17 PIK37356.1 - 0.056 13.6 0.8 0.11 12.7 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin V-set domain DUF3270 PF11674.8 PIK37356.1 - 0.12 12.6 0.1 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) LRRCT PF01463.24 PIK37356.1 - 0.13 12.9 0.3 1 10.1 0.0 2.8 4 0 0 4 4 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 PIK37356.1 - 1.6 9.6 28.2 24 6.0 0.2 8.0 8 0 0 8 8 8 0 Leucine Rich Repeat Trypan_PARP PF05887.11 PIK37357.1 - 1.3e-05 25.2 8.1 1.9e-05 24.6 8.1 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) NAR2 PF16974.5 PIK37357.1 - 0.21 11.0 0.2 0.35 10.3 0.2 1.3 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Adeno_E1A PF02703.14 PIK37357.1 - 0.22 11.1 6.0 0.91 9.1 5.3 2.1 2 0 0 2 2 2 0 Early E1A protein SPESP1 PF15754.5 PIK37357.1 - 6.9 5.7 5.9 11 5.1 5.9 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 TonB_N PF16031.5 PIK37357.1 - 8.6 6.9 14.2 20 5.7 14.2 1.6 1 0 0 1 1 1 0 TonB polyproline region RD3 PF14473.6 PIK37358.1 - 4.2e-28 97.8 2.2 7.4e-28 97.0 2.2 1.4 1 0 0 1 1 1 1 RD3 protein Dimer_Tnp_hAT PF05699.14 PIK37358.1 - 0.55 10.1 2.2 14 5.6 0.3 3.0 2 1 1 3 3 3 0 hAT family C-terminal dimerisation region zf-RING_2 PF13639.6 PIK37359.1 - 3e-12 46.7 6.1 4.2e-12 46.2 6.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 PIK37359.1 - 4.5e-11 42.3 4.6 4.5e-11 42.3 4.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK37359.1 - 9.2e-08 31.8 6.7 1.3e-07 31.3 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK37359.1 - 3.2e-07 30.3 3.7 6.3e-07 29.3 3.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK37359.1 - 1.5e-06 28.0 4.6 2.3e-06 27.4 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK37359.1 - 3.1e-06 27.0 2.6 4.9e-06 26.4 2.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK37359.1 - 5e-06 26.3 2.7 7.3e-06 25.8 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK37359.1 - 5.3e-06 26.6 7.5 1.6e-05 25.1 7.5 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 PIK37359.1 - 5.4e-05 22.7 2.9 0.0001 21.9 2.9 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 PIK37359.1 - 0.00085 19.1 3.5 0.0014 18.5 3.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 PIK37359.1 - 0.029 14.4 5.1 0.07 13.2 5.1 1.8 1 1 0 1 1 1 0 Zinc-finger zf-RING_6 PF14835.6 PIK37359.1 - 0.037 13.9 1.6 0.065 13.1 1.6 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 PIK37359.1 - 0.13 12.1 1.8 0.22 11.4 1.8 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 PIK37359.1 - 0.22 11.7 7.7 3.3 7.9 7.7 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 PIK37359.1 - 0.33 11.1 6.0 0.63 10.2 6.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 PIK37359.1 - 0.4 10.8 5.7 1.3 9.1 5.7 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger WD40 PF00400.32 PIK37361.1 - 3.7e-09 37.1 1.4 7.8e-09 36.0 0.1 2.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37361.1 - 0.0038 17.5 0.0 0.0054 17.0 0.0 1.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK37362.1 - 1.3e-14 54.3 13.3 2.4e-07 31.3 0.2 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat AAA_assoc_2 PF16193.5 PIK37363.1 - 0.00044 20.5 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain EF-hand_6 PF13405.6 PIK37364.1 - 0.0013 18.5 0.0 0.006 16.4 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 PIK37364.1 - 0.0017 17.8 0.0 0.0072 15.8 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK37364.1 - 0.0039 17.6 0.1 0.031 14.7 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair zf_Rg PF17915.1 PIK37364.1 - 0.036 13.4 0.5 8.6 5.9 0.0 2.4 2 0 0 2 2 2 0 Reverse gyrase zinc finger Collagen PF01391.18 PIK37364.1 - 0.045 13.5 13.2 3.6e+02 1.0 13.2 2.5 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Zip PF02535.22 PIK37365.1 - 4e-19 69.0 3.8 4.5e-19 68.8 3.8 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter fn3 PF00041.21 PIK37366.1 - 1.7e-27 95.6 12.5 7.3e-09 35.9 0.2 5.6 5 0 0 5 5 5 5 Fibronectin type III domain Interfer-bind PF09294.10 PIK37366.1 - 0.01 16.1 3.3 0.05 13.9 0.1 3.1 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III GPI-anchored PF10342.9 PIK37366.1 - 1.2 10.0 5.8 12 6.7 0.0 3.1 3 0 0 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF659 PF04937.15 PIK37367.1 - 0.0061 16.4 1.2 0.4 10.5 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF 659) zf-RRPl_C4 PF17026.5 PIK37367.1 - 2.6 8.2 6.2 3.7 7.7 1.0 3.1 3 1 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type MFS_1 PF07690.16 PIK37368.1 - 7.1e-22 77.8 24.1 7.1e-22 77.8 24.1 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 PIK37369.1 - 1.4e-08 34.1 25.2 0.0003 19.8 6.8 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily LRR_8 PF13855.6 PIK37370.1 - 3.7e-14 52.2 8.0 1e-10 41.2 1.3 3.3 2 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 PIK37370.1 - 1.5e-06 27.9 8.9 0.32 11.7 0.1 5.4 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_4 PF12799.7 PIK37370.1 - 7.8e-06 26.2 11.5 0.0006 20.2 0.9 3.8 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37370.1 - 0.0014 18.6 0.3 0.0034 17.3 0.0 1.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK37370.1 - 0.8 9.9 10.1 8.2 6.8 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat EGF PF00008.27 PIK37371.1 - 1.2e-254 821.6 710.5 5.6e-09 36.1 10.8 47.6 47 0 0 47 47 47 47 EGF-like domain hEGF PF12661.7 PIK37371.1 - 5.2e-124 401.2 640.7 2.4e-06 28.0 4.8 50.4 49 0 0 49 49 49 44 Human growth factor-like EGF EGF_2 PF07974.13 PIK37371.1 - 6.2e-46 154.4 801.8 0.0012 19.1 6.1 47.2 47 0 0 47 47 47 42 EGF-like domain EGF_CA PF07645.15 PIK37371.1 - 1.2e-05 25.5 10.4 1.2e-05 25.5 10.4 44.8 15 11 31 46 46 46 21 Calcium-binding EGF domain LRR_8 PF13855.6 PIK37372.1 - 3.8e-25 87.4 22.0 4.3e-15 55.2 6.8 3.1 2 1 1 3 3 3 2 Leucine rich repeat PIR PF00399.19 PIK37372.1 - 8.6e-17 60.2 20.9 0.47 10.1 0.0 8.4 8 0 0 8 8 8 7 Yeast PIR protein repeat LRR_4 PF12799.7 PIK37372.1 - 1.6e-15 57.0 38.1 2.5e-06 27.7 2.5 4.0 1 1 5 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37372.1 - 2.6e-13 50.0 2.2 7.8e-13 48.5 0.7 2.2 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37372.1 - 1.5e-05 24.6 6.0 0.003 17.1 2.2 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK37372.1 - 0.00034 20.4 17.4 0.66 10.2 0.1 6.0 5 0 0 5 5 5 2 Leucine Rich repeat LRRNT PF01462.18 PIK37372.1 - 0.14 11.8 4.2 0.2 11.4 0.1 3.0 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK37372.1 - 0.18 12.5 19.8 29 5.7 0.1 6.6 6 0 0 6 6 6 0 Leucine Rich Repeat Y_phosphatase PF00102.27 PIK37374.1 - 5e-88 294.6 10.3 1.4e-42 145.9 0.4 3.7 3 0 0 3 3 3 3 Protein-tyrosine phosphatase fn3 PF00041.21 PIK37374.1 - 6.9e-15 55.2 11.0 3.4e-06 27.3 5.1 4.4 3 1 0 3 3 3 3 Fibronectin type III domain Interfer-bind PF09294.10 PIK37374.1 - 0.00025 21.3 4.5 0.025 14.9 0.6 3.3 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.20 PIK37374.1 - 0.0009 19.1 5.2 0.0016 18.2 0.3 2.9 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Pur_ac_phosph_N PF16656.5 PIK37374.1 - 0.001 19.6 4.4 2.2 8.9 0.1 3.6 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Thioredoxin_13 PF18401.1 PIK37374.1 - 0.017 15.0 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain Phytochelatin PF05023.14 PIK37374.1 - 0.054 12.7 0.7 0.41 9.8 0.1 2.3 2 0 0 2 2 2 0 Phytochelatin synthase SusE PF14292.6 PIK37374.1 - 0.81 10.0 3.2 2.5 8.4 1.7 2.3 2 0 0 2 2 2 0 SusE outer membrane protein Fibrinogen_C PF00147.18 PIK37375.1 - 2.1e-57 194.4 4.6 2.9e-57 194.0 4.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK37375.1 - 0.00017 21.8 21.4 0.0011 19.2 12.6 2.3 2 0 0 2 2 2 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK37375.1 - 0.00023 21.3 7.0 0.00023 21.3 7.0 3.0 2 1 0 2 2 2 1 EGF domain Ephrin_rec_like PF07699.13 PIK37376.1 - 0.15 11.9 1.7 0.84 9.4 0.1 2.2 2 0 0 2 2 2 0 Putative ephrin-receptor like Pkinase_Tyr PF07714.17 PIK37378.1 - 1.7e-66 224.2 0.0 2.4e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37378.1 - 5.7e-27 94.7 0.0 9e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TMEM154 PF15102.6 PIK37378.1 - 0.008 16.1 0.2 0.015 15.2 0.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 PIK37378.1 - 0.014 15.7 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) MFS_2 PF13347.6 PIK37378.1 - 0.057 12.0 0.0 0.082 11.5 0.0 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein DUF4448 PF14610.6 PIK37378.1 - 0.081 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4381 PF14316.6 PIK37378.1 - 0.086 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TMEM132D_C PF15706.5 PIK37378.1 - 0.088 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PRIMA1 PF16101.5 PIK37378.1 - 0.11 12.5 0.1 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 PIK37378.1 - 0.14 13.1 0.1 0.26 12.2 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LRR_8 PF13855.6 PIK37379.1 - 8.5e-13 47.9 14.1 8.9e-12 44.6 4.1 4.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK37379.1 - 5.1e-09 36.3 16.7 4.3e-06 27.0 0.2 4.3 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK37379.1 - 8.1e-05 22.6 13.8 1.3 9.8 0.1 6.0 5 1 1 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK37379.1 - 0.034 13.7 1.9 0.069 12.7 0.7 2.0 2 0 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK37379.1 - 0.1 12.7 9.6 5.9 7.2 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 PIK37380.1 - 8.5e-13 47.9 14.1 8.9e-12 44.6 4.1 4.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK37380.1 - 5.1e-09 36.3 16.7 4.3e-06 27.0 0.2 4.3 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK37380.1 - 8.1e-05 22.6 13.8 1.3 9.8 0.1 6.0 5 1 1 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK37380.1 - 0.034 13.7 1.9 0.069 12.7 0.7 2.0 2 0 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK37380.1 - 0.1 12.7 9.6 5.9 7.2 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich repeat VWD PF00094.25 PIK37381.1 - 0.00052 20.3 0.1 0.00088 19.6 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain RGM_C PF06534.13 PIK37381.1 - 0.059 12.9 0.2 0.1 12.1 0.2 1.3 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) C-terminus Ycf34 PF10718.9 PIK37381.1 - 0.14 12.8 0.0 1.2 9.9 0.0 2.3 2 1 1 3 3 3 0 Hypothetical chloroplast protein Ycf34 AMOP PF03782.17 PIK37384.1 - 1.1e-18 67.7 4.5 1.7e-18 67.1 4.5 1.2 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK37384.1 - 4.3e-05 23.8 0.0 6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Mito_carr PF00153.27 PIK37385.1 - 5.7e-19 67.8 0.0 6.3e-19 67.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein WD40 PF00400.32 PIK37386.1 - 1.5e-55 183.9 24.6 2.8e-08 34.3 0.1 11.4 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 PIK37386.1 - 1.7e-42 144.6 1.3 3.2e-42 143.8 1.3 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 PIK37386.1 - 5.3e-20 71.5 9.8 0.00029 21.1 0.0 8.8 2 2 8 10 10 10 8 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 PIK37386.1 - 2.7e-07 29.7 11.5 0.19 10.4 0.0 6.1 2 2 3 5 5 5 3 Nup133 N terminal like Ge1_WD40 PF16529.5 PIK37386.1 - 1.6e-05 24.1 12.5 0.34 9.8 0.1 7.1 2 2 6 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK37386.1 - 0.00038 19.9 6.0 0.064 12.6 0.0 4.8 3 3 2 5 5 5 2 WD40-like domain Nup160 PF11715.8 PIK37386.1 - 0.00043 19.1 18.9 0.09 11.4 0.0 6.0 4 2 3 7 7 7 4 Nucleoporin Nup120/160 Nbas_N PF15492.6 PIK37386.1 - 0.085 12.2 1.1 5.6 6.2 0.0 3.2 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Hira PF07569.11 PIK37386.1 - 1.8 8.2 9.4 33 4.1 0.1 4.7 4 1 1 5 5 5 0 TUP1-like enhancer of split Pkinase PF00069.25 PIK37387.1 - 2.7e-51 174.5 0.0 3.1e-51 174.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37387.1 - 1.3e-34 119.6 0.0 1.6e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK37387.1 - 7.9e-05 22.1 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK37387.1 - 0.0011 18.1 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK37387.1 - 0.046 12.8 0.0 0.086 11.9 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 FAD_binding_7 PF03441.14 PIK37388.1 - 1.3e-60 204.3 0.2 2.1e-60 203.7 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 PIK37388.1 - 6.9e-36 123.7 0.0 1.1e-35 123.1 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Death PF00531.22 PIK37389.1 - 5.4e-06 26.5 0.0 1.8e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Death domain DUF4564 PF15169.6 PIK37392.1 - 1.1e-23 83.9 0.0 1.5e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) Peptidase_M50 PF02163.22 PIK37392.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M50 Utp12 PF04003.12 PIK37393.1 - 0.0004 20.7 3.9 0.0024 18.2 0.2 3.0 3 0 0 3 3 3 1 Dip2/Utp12 Family CDC24_OB3 PF17244.2 PIK37394.1 - 3.8e-05 23.5 0.5 5.3e-05 23.1 0.5 1.2 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 VHP PF02209.19 PIK37394.1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Villin headpiece domain RMI1_C PF16099.5 PIK37394.1 - 0.088 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold REPA_OB_2 PF16900.5 PIK37395.1 - 1.8e-07 31.0 0.1 6.3e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 Replication protein A OB domain EF-hand_1 PF00036.32 PIK37396.1 - 4e-26 88.6 4.6 2.8e-06 26.5 0.1 5.3 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 PIK37396.1 - 3.2e-23 79.6 6.6 8.1e-06 25.4 0.1 5.2 4 1 1 5 5 5 5 EF-hand domain EF-hand_7 PF13499.6 PIK37396.1 - 1.1e-21 77.0 1.6 3.9e-09 36.8 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK37396.1 - 6.6e-18 64.3 1.7 2.3e-07 30.6 0.2 3.4 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK37396.1 - 3.2e-17 61.2 3.6 4.6e-05 22.7 0.1 4.5 5 0 0 5 5 5 3 EF hand Scytalone_dh PF02982.14 PIK37396.1 - 0.043 13.6 0.0 0.67 9.7 0.0 2.1 2 0 0 2 2 2 0 Scytalone dehydratase SPARC_Ca_bdg PF10591.9 PIK37396.1 - 0.081 13.2 0.7 0.18 12.2 0.7 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region HEAT PF02985.22 PIK37397.1 - 0.049 13.9 0.3 1.8 9.1 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 PIK37397.1 - 0.058 13.8 0.0 0.73 10.3 0.0 2.7 3 0 0 3 3 3 0 HEAT repeats APOBEC3 PF18771.1 PIK37397.1 - 0.07 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 APOBEC3 FCP1_C PF09309.10 PIK37398.1 - 1.9 8.3 7.9 2.9 7.7 7.9 1.2 1 0 0 1 1 1 0 FCP1, C-terminal Sulfatase PF00884.23 PIK37399.1 - 7.5e-39 133.9 0.0 3.5e-38 131.7 0.0 1.8 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK37399.1 - 1.2e-06 28.4 0.1 0.0018 17.9 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 PIK37399.1 - 0.018 14.1 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Sulfatase PF00884.23 PIK37400.1 - 3.8e-40 138.2 0.0 1.3e-38 133.2 0.0 2.2 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK37400.1 - 3.9e-05 23.4 0.0 0.048 13.3 0.1 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 PIK37400.1 - 0.00023 21.4 1.4 0.00023 21.4 1.4 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4976) DUF1501 PF07394.12 PIK37400.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) RabGAP-TBC PF00566.18 PIK37404.1 - 1.2e-49 168.9 0.7 1.5e-49 168.5 0.7 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 PIK37405.1 - 1.5e-32 112.4 0.1 2.7e-32 111.6 0.1 1.4 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 PIK37405.1 - 2.4e-09 36.7 0.1 7.9e-09 35.0 0.1 1.9 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK37405.1 - 1.7e-08 34.0 0.0 3.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK37405.1 - 2e-06 27.5 0.0 5.9e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 Variant SH3 domain Nucleo_P87 PF07267.11 PIK37405.1 - 0.15 10.8 0.4 0.21 10.4 0.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 7tm_1 PF00001.21 PIK37406.1 - 3.7e-35 121.5 22.7 5e-35 121.1 22.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK37406.1 - 1.1e-10 41.4 28.9 1.4e-10 41.0 28.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK37406.1 - 1.2e-09 37.9 27.7 4.7e-07 29.4 9.6 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK37406.1 - 4.2e-09 36.4 25.8 8.7e-08 32.1 25.6 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK37406.1 - 5.8e-06 25.9 28.3 1.3e-05 24.8 28.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Homeodomain PF00046.29 PIK37407.1 - 0.59 10.0 5.1 1.4 8.8 5.1 1.7 1 0 0 1 1 1 0 Homeodomain Prefoldin_2 PF01920.20 PIK37408.1 - 1.4e-25 89.3 4.8 1.8e-25 88.9 4.8 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 PIK37408.1 - 0.0015 18.4 1.6 0.0081 16.1 0.5 2.0 1 1 1 2 2 2 1 Prefoldin subunit OmpH PF03938.14 PIK37408.1 - 0.002 18.5 2.0 0.004 17.5 0.5 1.9 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Med9 PF07544.13 PIK37408.1 - 0.0027 17.7 4.8 0.003 17.6 1.8 2.1 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 DegS PF05384.11 PIK37408.1 - 0.0077 15.7 3.3 0.055 13.0 1.0 2.0 2 0 0 2 2 2 1 Sensor protein DegS DASH_Spc34 PF08657.10 PIK37408.1 - 0.0096 15.7 3.2 1.5 8.6 1.3 2.0 2 0 0 2 2 2 2 DASH complex subunit Spc34 APG6_N PF17675.1 PIK37408.1 - 0.016 15.7 6.1 0.21 12.1 2.2 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4795 PF16043.5 PIK37408.1 - 0.046 13.3 1.8 1.2 8.6 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DUF1488 PF07369.11 PIK37408.1 - 0.063 13.3 0.1 11 6.1 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1488) DUF3738 PF12543.8 PIK37408.1 - 0.065 13.4 0.0 0.065 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) SKA1 PF07160.12 PIK37408.1 - 0.07 13.0 2.5 0.83 9.4 0.9 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 HALZ PF02183.18 PIK37408.1 - 0.081 13.2 2.8 0.092 13.0 0.1 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper RNA_GG_bind PF10258.9 PIK37408.1 - 0.14 12.2 1.7 0.3 11.2 0.3 2.1 1 1 1 2 2 2 0 PHAX RNA-binding domain DUF4201 PF13870.6 PIK37408.1 - 0.14 11.9 6.3 0.41 10.4 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Nas2_N PF18265.1 PIK37408.1 - 0.16 11.9 1.5 7.6 6.5 0.3 2.2 2 0 0 2 2 2 0 Nas2 N_terminal domain EF-G-binding_N PF07299.11 PIK37408.1 - 0.21 12.1 1.5 14 6.3 0.1 2.1 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DivIVA PF05103.13 PIK37408.1 - 0.35 11.0 5.9 2 8.5 0.4 2.1 2 0 0 2 2 2 0 DivIVA protein DUF1664 PF07889.12 PIK37408.1 - 0.57 10.2 3.1 7.2 6.7 0.5 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Sec7_N PF12783.7 PIK37411.1 - 4e-31 108.1 4.6 4.5e-31 107.9 3.9 1.4 1 1 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal CLASP_N PF12348.8 PIK37411.1 - 0.098 12.2 0.7 0.23 11.0 0.2 1.8 2 1 0 2 2 2 0 CLASP N terminal Sec7 PF01369.20 PIK37412.1 - 1.8e-52 177.7 0.1 2.2e-52 177.4 0.1 1.0 1 0 0 1 1 1 1 Sec7 domain MethyTransf_Reg PF10119.9 PIK37412.1 - 0.035 14.8 0.7 0.14 12.9 0.4 2.0 2 0 0 2 2 2 0 Predicted methyltransferase regulatory domain Importin_rep_5 PF18816.1 PIK37413.1 - 0.12 12.7 0.1 0.5 10.7 0.0 2.0 2 0 0 2 2 2 0 Importin repeat RVT_1 PF00078.27 PIK37416.1 - 3.7e-38 131.3 0.0 4.5e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-set PF07686.17 PIK37417.1 - 0.0088 16.2 0.1 0.0088 16.2 0.1 2.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain zf-CCHC PF00098.23 PIK37418.1 - 1 9.6 3.2 0.51 10.5 0.6 1.9 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 PIK37419.1 - 5.3e-15 55.5 0.0 7.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK37420.1 - 1.2e-24 86.8 0.0 1.6e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK37420.1 - 3e-19 68.9 3.2 5.2e-19 68.1 3.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK37420.1 - 3.1e-05 23.7 0.0 7.5e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK37420.1 - 0.00018 21.7 0.8 0.00036 20.7 0.8 1.5 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK37421.1 - 2e-28 99.4 0.1 2.7e-28 99.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_S58 PF03576.14 PIK37422.1 - 0.16 11.4 0.0 5.5 6.4 0.0 2.0 2 0 0 2 2 2 0 Peptidase family S58 MBOAT PF03062.19 PIK37423.1 - 2.1e-13 50.4 20.4 2.1e-13 50.4 20.4 2.3 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF1129 PF06570.11 PIK37423.1 - 0.17 11.4 2.8 0.88 9.0 2.8 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) KleE PF17394.2 PIK37423.1 - 1.9 8.7 6.8 0.7 10.1 0.1 3.2 3 1 0 3 3 3 0 Uncharacterized KleE stable inheritance protein Thyroglobulin_1 PF00086.18 PIK37424.1 - 1e-30 105.2 14.8 2.2e-15 56.1 2.4 3.1 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat SPARC_Ca_bdg PF10591.9 PIK37424.1 - 9.3e-25 87.2 11.4 6.4e-13 49.0 1.6 2.6 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 PIK37424.1 - 6.3e-09 35.8 6.5 6.3e-09 35.8 6.5 2.8 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 PIK37424.1 - 1.2e-05 25.7 2.1 0.11 13.0 0.2 3.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK37424.1 - 8.6e-05 21.8 3.7 0.5 10.0 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 PIK37424.1 - 0.00064 19.4 2.7 0.26 11.3 0.1 3.7 4 0 0 4 4 4 1 EF-hand domain Kazal_1 PF00050.21 PIK37424.1 - 0.0023 17.9 6.0 0.0023 17.9 6.0 3.9 4 0 0 4 4 4 1 Kazal-type serine protease inhibitor domain EF-hand_5 PF13202.6 PIK37424.1 - 0.011 15.3 0.7 6.3 6.5 0.1 3.1 3 0 0 3 3 3 0 EF hand DnaJ PF00226.31 PIK37425.1 - 5.8e-22 77.6 3.2 1.3e-21 76.5 3.2 1.6 1 0 0 1 1 1 1 DnaJ domain Cas_Csa4 PF09703.10 PIK37425.1 - 0.002 17.5 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csa4) Glyco_hydro_98M PF08306.11 PIK37425.1 - 0.013 14.9 0.4 0.31 10.3 0.1 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 98 zinc_ribbon_12 PF11331.8 PIK37425.1 - 0.058 13.2 0.4 0.53 10.1 0.2 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain Ribosomal_L18_c PF14204.6 PIK37425.1 - 0.87 10.6 7.6 0.19 12.7 2.5 2.1 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region p450 PF00067.22 PIK37426.1 - 1.6e-50 172.2 0.1 7.8e-46 156.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Neur_chan_LBD PF02931.23 PIK37427.1 - 2.2e-12 46.9 0.9 2.4e-12 46.8 0.9 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CPP1-like PF11833.8 PIK37429.1 - 0.096 12.3 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like BAALC_N PF06989.12 PIK37429.1 - 0.16 12.3 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 BAALC N-terminus Neur_chan_LBD PF02931.23 PIK37430.1 - 6.8e-22 78.0 0.0 9.2e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Lectin_C PF00059.21 PIK37431.1 - 4e-21 75.8 0.1 6.1e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK37431.1 - 0.00043 20.0 0.2 0.02 14.5 0.1 2.0 2 0 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like 7tm_1 PF00001.21 PIK37433.1 - 4.9e-24 85.1 22.4 7.5e-24 84.5 22.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0542 PF15086.6 PIK37433.1 - 0.2 11.6 0.7 0.62 10.0 0.7 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Macro PF01661.21 PIK37434.1 - 0.58 10.2 4.6 12 6.0 0.0 3.2 1 1 2 4 4 4 0 Macro domain DUF2115 PF09888.9 PIK37434.1 - 1 9.8 6.4 0.44 11.1 3.5 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) FUSC PF04632.12 PIK37434.1 - 7.2 5.0 12.1 9.1 4.7 12.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HEAT_2 PF13646.6 PIK37436.1 - 0.077 13.4 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 HEAT repeats Nuc_deoxyrib_tr PF05014.15 PIK37436.1 - 0.32 11.0 4.2 2.5 8.1 0.7 2.4 2 1 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase DUF2554 PF10829.8 PIK37436.1 - 0.35 11.3 2.3 0.34 11.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2554) Gp5_C PF06715.12 PIK37436.1 - 2.8 8.3 8.5 1.1 9.5 0.6 3.4 3 0 0 3 3 3 0 Gp5 C-terminal repeat (3 copies) GST_C_3 PF14497.6 PIK37437.1 - 1.4e-19 70.1 0.0 1.9e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK37437.1 - 9.5e-11 41.8 0.0 1.2e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK37437.1 - 7.7e-06 25.8 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK37437.1 - 0.082 13.3 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Stm1_N PF09598.10 PIK37438.1 - 0.6 11.0 2.6 1.1 10.1 2.6 1.4 1 0 0 1 1 1 0 Stm1 PGAP1 PF07819.13 PIK37439.1 - 1.4e-52 178.7 0.8 2.4e-33 115.8 0.1 2.3 1 1 1 2 2 2 2 PGAP1-like protein Pyr_redox_2 PF07992.14 PIK37440.1 - 1.3e-07 31.1 0.0 2.7e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK37440.1 - 2.7e-06 26.9 0.0 9.5e-06 25.1 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 PIK37440.1 - 1.4e-05 24.6 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK37440.1 - 8.2e-05 21.9 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 PIK37440.1 - 0.00011 22.6 0.0 0.00086 19.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK37440.1 - 0.00022 20.0 0.0 0.00034 19.4 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 PIK37440.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 PIK37440.1 - 0.0018 17.4 0.0 0.0026 16.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 PIK37440.1 - 0.0042 16.4 0.0 0.0075 15.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 PIK37440.1 - 0.0079 15.5 0.0 0.031 13.5 0.0 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 PIK37440.1 - 0.009 16.2 0.1 0.025 14.8 0.0 1.7 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain VanW PF04294.13 PIK37440.1 - 0.014 15.0 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 VanW like protein NAD_binding_7 PF13241.6 PIK37440.1 - 0.015 15.7 0.0 0.022 15.2 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 PIK37440.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 PIK37440.1 - 0.018 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase MFS_1_like PF12832.7 PIK37442.1 - 2.3e-26 92.6 6.6 3e-26 92.2 6.6 1.0 1 0 0 1 1 1 1 MFS_1 like family DUF4260 PF14079.6 PIK37442.1 - 0.051 13.5 1.7 0.09 12.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4260) p450 PF00067.22 PIK37443.1 - 9.4e-21 74.1 0.0 1.1e-20 73.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK37444.1 - 2e-88 297.2 0.1 2.4e-88 296.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3383 PF11863.8 PIK37444.1 - 0.2 10.6 0.1 0.27 10.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3383) adh_short PF00106.25 PIK37445.1 - 4.1e-33 114.5 0.1 2.7e-32 111.8 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37445.1 - 9.6e-22 77.7 0.0 3.4e-21 75.9 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK37445.1 - 1.2e-10 41.6 0.0 1.7e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 KR domain PARP PF00644.20 PIK37446.1 - 1.5e-58 197.6 0.0 1.5e-58 197.6 0.0 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 PIK37446.1 - 4.1e-49 166.2 4.4 9.6e-49 165.0 4.4 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain zf-PARP PF00645.18 PIK37446.1 - 2.7e-37 127.5 8.4 2.5e-18 66.7 1.6 3.1 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PADR1 PF08063.12 PIK37446.1 - 3.8e-20 71.4 0.3 3.8e-20 71.4 0.3 2.4 3 0 0 3 3 3 1 PADR1 (NUC008) domain WGR PF05406.15 PIK37446.1 - 4.7e-20 71.4 0.7 1.7e-19 69.7 0.2 2.3 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 PIK37446.1 - 2.7e-10 40.5 1.4 4.9e-10 39.6 0.3 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK37446.1 - 1.8e-05 25.1 0.2 8.3e-05 22.9 0.1 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 PIK37446.1 - 0.00016 21.6 0.5 0.00049 20.0 0.5 1.9 1 0 0 1 1 1 1 twin BRCT domain GCN5L1 PF06320.13 PIK37446.1 - 0.082 13.1 1.9 0.12 12.5 0.1 2.2 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Acyl_transf_3 PF01757.22 PIK37448.1 - 8.8e-18 64.5 48.6 8.8e-18 64.5 48.6 2.0 2 0 0 2 2 2 1 Acyltransferase family Acyl_transf_3 PF01757.22 PIK37449.1 - 2.8e-12 46.4 46.0 2.8e-12 46.4 46.0 2.5 2 1 0 2 2 2 1 Acyltransferase family Peptidase_M41 PF01434.18 PIK37450.1 - 9.8e-67 224.5 0.0 1.7e-66 223.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 PIK37450.1 - 1.8e-42 144.9 0.0 3.1e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK37450.1 - 2.3e-11 43.3 0.1 5.4e-11 42.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 PIK37450.1 - 7.3e-10 39.2 0.0 2.6e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 PIK37450.1 - 0.0022 18.0 0.1 0.0082 16.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 PIK37450.1 - 0.0028 17.8 0.0 0.0071 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK37450.1 - 0.0057 16.9 0.0 0.25 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 PIK37450.1 - 0.0069 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 PIK37450.1 - 0.024 15.0 0.1 0.18 12.2 0.1 2.3 1 1 0 2 2 2 0 AAA ATPase domain RuvB_N PF05496.12 PIK37450.1 - 0.032 14.0 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 PIK37450.1 - 0.063 12.6 0.4 0.71 9.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 PIK37450.1 - 0.072 13.3 0.3 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sec7 PF01369.20 PIK37450.1 - 0.085 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Sec7 domain IstB_IS21 PF01695.17 PIK37450.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 PIK37450.1 - 0.17 11.2 0.1 0.41 10.0 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI zf-H2C2_5 PF13909.6 PIK37452.1 - 1.7e-19 69.2 74.0 7.3e-07 28.8 1.9 9.6 9 2 0 9 9 9 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK37452.1 - 6.4e-19 67.3 76.6 0.0031 17.9 2.7 10.1 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK37452.1 - 1.6e-13 50.4 56.6 8.9e-05 22.7 2.4 10.8 11 0 0 11 11 11 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK37452.1 - 1.1e-09 38.3 69.5 0.16 12.9 0.0 10.3 10 0 0 10 10 10 5 C2H2-type zinc finger Actin_micro PF17003.5 PIK37452.1 - 0.00033 20.0 32.5 0.01 15.0 0.0 5.9 2 2 4 6 6 5 2 Putative actin-like family zf-C2H2_6 PF13912.6 PIK37452.1 - 0.0058 16.6 0.0 0.0058 16.6 0.0 7.3 9 1 0 9 9 9 1 C2H2-type zinc finger zf-Di19 PF05605.12 PIK37452.1 - 0.053 13.8 42.8 0.034 14.5 2.6 6.0 6 1 0 6 6 5 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 PIK37452.1 - 0.071 13.8 26.7 0.076 13.7 0.2 5.3 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats AKAP95 PF04988.12 PIK37452.1 - 0.75 10.0 0.0 0.75 10.0 0.0 6.1 5 1 2 7 7 5 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 PIK37452.1 - 2.3 8.6 47.3 0.96 9.8 0.1 8.0 2 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) OrsD PF12013.8 PIK37452.1 - 6.3 7.3 39.0 6 7.4 1.7 6.6 3 1 3 6 6 6 0 Orsellinic acid/F9775 biosynthesis cluster protein D LRR_9 PF14580.6 PIK37453.1 - 2.8e-09 36.7 0.0 5.5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK37453.1 - 1.5e-08 34.8 6.2 9.8e-07 29.0 0.8 3.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK37453.1 - 1.3e-05 24.9 3.0 0.00063 19.5 2.3 2.6 1 1 1 2 2 2 2 Leucine rich repeat IQ PF00612.27 PIK37453.1 - 0.00024 20.6 11.2 0.045 13.5 2.4 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif Arf PF00025.21 PIK37454.1 - 6e-60 201.7 0.0 7.2e-60 201.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 PIK37454.1 - 1.8e-14 53.7 0.0 2.2e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK37454.1 - 2.6e-14 53.4 0.0 3.9e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK37454.1 - 2.4e-12 46.7 0.0 3.1e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK37454.1 - 1.5e-10 40.8 0.0 1.7e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 PIK37454.1 - 2.8e-08 33.3 0.2 5.7e-05 22.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK37454.1 - 0.00037 20.6 0.0 0.00064 19.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK37454.1 - 0.0032 16.8 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_16 PF13191.6 PIK37454.1 - 0.021 15.2 0.2 0.46 10.8 0.1 2.3 2 1 0 3 3 3 0 AAA ATPase domain AAA_25 PF13481.6 PIK37454.1 - 0.046 13.3 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain ACT PF01842.25 PIK37454.1 - 0.16 11.7 0.0 0.47 10.3 0.0 1.8 1 0 0 1 1 1 0 ACT domain AAA_18 PF13238.6 PIK37454.1 - 0.17 12.4 0.1 0.71 10.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain zf-HIT PF04438.16 PIK37456.1 - 3.6e-06 26.7 8.9 5.2e-06 26.2 8.9 1.3 1 0 0 1 1 1 1 HIT zinc finger ANF_receptor PF01094.28 PIK37457.1 - 7.7e-20 71.3 0.0 8.4e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region TFIID_NTD2 PF04494.15 PIK37459.1 - 5.3e-10 39.6 0.0 3.1e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 PIK37460.1 - 1.4e-29 101.7 5.7 2.5e-08 34.5 0.0 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37460.1 - 3.7e-06 27.1 0.0 0.0029 17.9 0.0 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Fels1 PF05666.11 PIK37460.1 - 0.05 13.3 0.1 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 Fels-1 Prophage Protein-like TPD52 PF04201.15 PIK37461.1 - 1.1e-37 129.1 0.1 1.8e-37 128.5 0.1 1.2 1 0 0 1 1 1 1 Tumour protein D52 family Cupin_2 PF07883.11 PIK37462.1 - 0.018 14.7 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 Cupin domain CDO_I PF05995.12 PIK37462.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I RT_RNaseH_2 PF17919.1 PIK37463.1 - 4.3e-33 113.3 0.0 8.9e-33 112.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37463.1 - 1.6e-23 83.0 0.0 4.1e-23 81.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37463.1 - 2e-11 43.8 0.0 3.4e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK37464.1 - 3.1e-21 75.2 1.3 6.9e-21 74.1 1.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK37464.1 - 4.8e-19 68.7 0.0 1.4e-18 67.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-C2H2_10 PF16588.5 PIK37464.1 - 4e-05 23.2 1.5 8.5e-05 22.2 1.5 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger zf-H2C2 PF09337.10 PIK37464.1 - 5.6e-05 23.3 0.4 0.00013 22.1 0.4 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK37464.1 - 0.05 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.23 PIK37464.1 - 0.3 11.3 4.5 0.54 10.4 1.1 2.4 2 0 0 2 2 2 0 Zinc knuckle CD20 PF04103.15 PIK37465.1 - 8e-07 29.3 14.3 8e-07 29.3 14.3 2.1 1 1 1 2 2 2 1 CD20-like family BCLP PF12304.8 PIK37465.1 - 1.1 8.8 13.2 0.14 11.7 6.2 2.3 2 1 0 2 2 2 0 Beta-casein like protein DUF948 PF06103.11 PIK37468.1 - 0.015 15.5 0.1 0.032 14.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4149 PF13664.6 PIK37469.1 - 0.14 12.5 0.7 0.23 11.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) UPF0556 PF10572.9 PIK37471.1 - 2.7e-37 127.6 0.0 3.1e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0556 BTB_2 PF02214.22 PIK37472.1 - 5.1e-17 62.0 0.0 8.7e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 PIK37472.1 - 0.0032 17.5 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Adeno_E1B_19K PF01691.16 PIK37472.1 - 0.017 14.6 0.0 0.36 10.4 0.1 2.1 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen Mito_carr PF00153.27 PIK37473.1 - 7.4e-11 41.8 0.1 1.1e-09 38.1 0.0 2.6 2 1 1 3 3 3 1 Mitochondrial carrier protein Ig_3 PF13927.6 PIK37474.1 - 6.7e-08 33.0 6.1 0.027 15.1 0.8 3.5 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK37474.1 - 2.3e-06 27.5 0.2 0.015 15.3 0.0 3.0 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK37474.1 - 4.1e-06 27.0 6.0 0.1 12.9 1.4 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK37474.1 - 0.00066 19.8 3.0 1.3 9.3 0.3 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK37474.1 - 0.0017 18.4 0.2 0.51 10.4 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 PIK37474.1 - 0.95 9.7 6.8 11 6.3 0.1 3.3 3 1 0 3 3 3 0 Immunoglobulin V-set domain Pkinase PF00069.25 PIK37475.1 - 0.00011 21.7 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37475.1 - 0.00026 20.4 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Helicase_C_2 PF13307.6 PIK37477.1 - 6.7e-55 185.9 0.0 1.4e-54 184.8 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 PIK37477.1 - 1.6e-53 180.9 0.8 2.6e-53 180.3 0.8 1.3 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 PIK37477.1 - 1.2e-05 25.4 0.1 0.021 14.8 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK37477.1 - 0.00067 19.5 0.1 0.071 12.9 0.1 2.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.23 PIK37477.1 - 0.00085 18.1 0.1 0.0072 15.1 0.1 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain HBB PF06777.11 PIK37477.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Helical and beta-bridge domain DUF1722 PF08349.11 PIK37478.1 - 0.0015 18.8 0.2 0.0025 18.1 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1722) CCM2_C PF16545.5 PIK37478.1 - 0.0028 18.2 0.1 0.0037 17.7 0.1 1.2 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PAH PF02671.21 PIK37478.1 - 0.0036 17.4 0.5 0.0071 16.5 0.5 1.5 1 1 0 1 1 1 1 Paired amphipathic helix repeat MIS13 PF08202.11 PIK37479.1 - 6.7e-07 28.9 8.5 4.9e-06 26.1 1.1 2.6 1 1 1 2 2 2 2 Mis12-Mtw1 protein family SIN1_PH PF16979.5 PIK37480.1 - 1.2e-34 118.8 0.8 1.2e-34 118.8 0.8 2.2 3 0 0 3 3 3 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology CRIM PF16978.5 PIK37480.1 - 7.9e-25 87.6 0.3 6.6e-23 81.4 0.0 2.8 2 1 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.12 PIK37480.1 - 3.3e-14 53.7 3.4 7.6e-14 52.5 3.4 1.6 1 0 0 1 1 1 1 Stress-activated map kinase interacting protein 1 (SIN1) PBC PF03792.13 PIK37481.1 - 7.4e-84 280.2 0.1 1.1e-83 279.7 0.1 1.2 1 0 0 1 1 1 1 PBC domain Homeodomain PF00046.29 PIK37481.1 - 4e-19 68.2 1.3 7.6e-19 67.3 1.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK37481.1 - 3.7e-15 55.5 0.0 1.1e-14 54.0 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 PIK37481.1 - 0.015 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sec15 PF04091.12 PIK37481.1 - 0.062 12.7 0.8 0.09 12.2 0.8 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like Ribosomal_60s PF00428.19 PIK37481.1 - 2.7 8.6 8.6 3.5 8.3 2.0 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Hemopexin PF00045.19 PIK37482.1 - 4e-13 49.1 4.3 8.5e-05 22.4 0.0 4.0 4 0 0 4 4 4 3 Hemopexin Tachylectin PF14517.6 PIK37482.1 - 0.034 13.7 0.2 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Tachylectin Peptidase_M10 PF00413.24 PIK37483.1 - 1.1e-16 61.1 0.3 1.7e-16 60.5 0.3 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK37483.1 - 1e-12 47.8 4.3 0.00012 22.0 0.0 4.0 4 0 0 4 4 4 3 Hemopexin DUF4953 PF16313.5 PIK37483.1 - 0.0021 17.3 0.1 0.0033 16.7 0.1 1.2 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.6 PIK37483.1 - 0.0026 18.3 0.5 0.0093 16.5 0.3 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK37483.1 - 0.0059 16.3 1.0 0.015 15.0 1.0 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Tachylectin PF14517.6 PIK37483.1 - 0.034 13.7 0.3 0.13 11.8 0.1 1.8 2 0 0 2 2 2 0 Tachylectin Reprolysin_5 PF13688.6 PIK37483.1 - 0.036 14.2 0.1 0.072 13.2 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12 Astacin PF01400.24 PIK37483.1 - 0.068 12.8 0.2 0.12 11.9 0.2 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Metallopep PF12044.8 PIK37483.1 - 0.16 10.6 0.1 0.23 10.0 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Neur_chan_LBD PF02931.23 PIK37484.1 - 3e-47 160.9 0.9 3.7e-47 160.6 0.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain PAP2 PF01569.21 PIK37485.1 - 1.2e-22 80.1 4.5 2.3e-22 79.2 3.0 2.0 2 0 0 2 2 2 1 PAP2 superfamily LrgB PF04172.16 PIK37485.1 - 0.028 13.9 0.2 0.06 12.9 0.2 1.5 1 0 0 1 1 1 0 LrgB-like family UPF0016 PF01169.19 PIK37485.1 - 0.029 14.7 0.8 0.097 13.0 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 FeoB_associated PF12669.7 PIK37485.1 - 0.03 14.7 0.1 0.23 11.9 0.0 2.5 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein PAP2_C PF14360.6 PIK37485.1 - 0.034 14.7 5.1 0.034 14.7 5.1 1.9 2 0 0 2 2 2 0 PAP2 superfamily C-terminal RseC_MucC PF04246.12 PIK37485.1 - 0.086 12.8 0.2 0.2 11.6 0.2 1.6 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Inhibitor_I48 PF10467.9 PIK37485.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor clitocypin Fmp27_WPPW PF10359.9 PIK37486.1 - 0.0099 14.8 5.6 0.013 14.4 5.6 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain CortBP2 PF09727.9 PIK37486.1 - 0.15 12.0 16.9 0.13 12.2 11.4 2.2 1 1 1 2 2 2 0 Cortactin-binding protein-2 AAA_11 PF13086.6 PIK37486.1 - 0.26 11.1 6.8 0.4 10.4 6.8 1.2 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 PIK37486.1 - 0.61 10.1 5.6 0.77 9.8 0.5 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 PIK37486.1 - 1.2 9.2 11.0 2.4 8.2 11.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 PIK37486.1 - 3 6.6 14.9 6.6 5.5 15.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein ADIP PF11559.8 PIK37486.1 - 3.2 7.8 18.4 0.35 11.0 10.0 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FapA PF03961.13 PIK37486.1 - 4.6 5.7 6.5 8.9 4.8 5.6 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF745 PF05335.13 PIK37486.1 - 4.9 6.8 9.1 3 7.5 5.9 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF745) HTH_44 PF14641.6 PIK37487.1 - 1.8e-12 47.7 1.4 1.8e-12 47.7 1.4 2.8 2 1 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 PIK37487.1 - 1.8e-08 34.8 20.9 1.8e-08 34.8 20.9 6.2 3 2 2 5 5 5 1 Acidic N-terminal SPT6 HHH_7 PF14635.6 PIK37488.1 - 1.2e-36 125.2 0.1 2.9e-36 124.0 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 PIK37488.1 - 3.5e-32 111.3 0.0 8.9e-32 110.0 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_9 PF17674.1 PIK37488.1 - 1.6e-07 32.2 0.2 6.3e-07 30.2 0.2 2.2 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 PIK37488.1 - 3.2e-06 27.6 0.1 7.9e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_3 PF12836.7 PIK37488.1 - 0.00023 21.3 0.1 0.0019 18.4 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif RT_RNaseH_2 PF17919.1 PIK37489.1 - 2.7e-22 78.7 0.0 3.8e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37489.1 - 3.3e-11 43.4 0.0 5.6e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK37490.1 - 1.4e-19 70.0 0.3 3.9e-19 68.5 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK37490.1 - 1.5e-07 31.7 0.1 2.6e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK37490.1 - 2.1e-07 31.0 0.8 5.9e-07 29.6 0.8 1.8 1 0 0 1 1 1 1 H2C2 zinc finger zf-trcl PF13451.6 PIK37490.1 - 0.13 12.2 1.8 0.15 11.9 0.7 1.7 2 0 0 2 2 2 0 Probable zinc-ribbon domain SKN1 PF03935.15 PIK37491.1 - 0.058 11.8 0.0 0.09 11.2 0.0 1.2 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) Inhibitor_I9 PF05922.16 PIK37492.1 - 0.00023 21.7 0.0 0.00029 21.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I9 V-set PF07686.17 PIK37494.1 - 1e-06 28.9 0.1 4.9e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK37494.1 - 1.8e-05 24.7 0.0 7.5e-05 22.7 0.0 2.1 2 0 0 2 2 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK37494.1 - 2.1e-05 25.1 1.0 9.7e-05 22.9 0.1 2.6 3 0 0 3 3 2 1 Immunoglobulin domain NACHT PF05729.12 PIK37494.1 - 2.5e-05 24.3 0.2 4.8e-05 23.3 0.2 1.4 1 0 0 1 1 1 1 NACHT domain ig PF00047.25 PIK37494.1 - 0.0018 18.4 0.9 0.016 15.4 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Lyase_8_C PF02884.17 PIK37494.1 - 0.0026 18.2 0.0 2 9.0 0.0 2.9 3 0 0 3 3 3 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Protocadherin PF08374.11 PIK37494.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Protocadherin KAP_NTPase PF07693.14 PIK37494.1 - 0.023 13.9 0.3 0.023 13.9 0.3 3.0 2 1 0 3 3 3 0 KAP family P-loop domain FAM176 PF14851.6 PIK37494.1 - 0.03 14.0 1.4 0.051 13.2 0.1 1.9 2 0 0 2 2 2 0 FAM176 family EphA2_TM PF14575.6 PIK37494.1 - 0.063 14.2 0.2 0.25 12.2 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain AAA_19 PF13245.6 PIK37494.1 - 0.073 13.4 0.1 0.21 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain Syndecan PF01034.20 PIK37494.1 - 0.079 12.9 0.1 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 Syndecan domain CcmH PF03918.14 PIK37494.1 - 0.094 12.0 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein EP400_N PF15790.5 PIK37495.1 - 0.11 11.3 0.5 1.5 7.5 0.2 2.1 2 0 0 2 2 2 0 E1A-binding protein p400, N-terminal V-set PF07686.17 PIK37496.1 - 2.3e-07 30.9 0.1 8.4e-07 29.1 0.0 1.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK37496.1 - 1.5e-06 28.2 0.0 3e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK37496.1 - 2.1e-06 28.3 1.3 2.6e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK37496.1 - 2.7e-05 24.3 1.3 0.00043 20.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain DCB PF16213.5 PIK37497.1 - 7.9e-53 178.8 4.7 1.6e-52 177.8 4.7 1.4 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 PIK37497.1 - 2.2e-50 170.6 0.1 4.4e-50 169.7 0.1 1.5 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal WASH_WAHD PF11945.8 PIK37500.1 - 5.2e-92 308.5 3.4 7.5e-92 308.0 3.4 1.2 1 0 0 1 1 1 1 WAHD domain of WASH complex DUF2357 PF09823.9 PIK37500.1 - 0.043 13.1 0.6 0.078 12.2 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) KxDL PF10241.9 PIK37500.1 - 0.2 12.0 2.9 0.16 12.3 0.6 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein RP-C_C PF11800.8 PIK37500.1 - 0.27 11.3 1.6 0.33 11.0 0.5 1.7 2 0 0 2 2 2 0 Replication protein C C-terminal region Exonuc_VII_L PF02601.15 PIK37500.1 - 0.62 9.6 4.5 2.3 7.7 0.8 2.4 3 0 0 3 3 3 0 Exonuclease VII, large subunit Mito_fiss_reg PF05308.11 PIK37500.1 - 2 8.4 12.8 0.49 10.4 8.8 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator DEC-1_N PF04625.13 PIK37500.1 - 6.9 5.6 14.0 10 5.0 14.0 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region zf-CCHC_4 PF14392.6 PIK37501.1 - 0.00018 21.2 11.7 0.18 11.6 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 PIK37501.1 - 0.00057 19.8 14.9 0.0021 18.1 3.3 3.2 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK37501.1 - 0.54 10.5 10.8 0.22 11.8 5.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-CCHC_2 PF13696.6 PIK37501.1 - 1.1 9.2 14.6 0.37 10.6 0.4 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC PF00098.23 PIK37503.1 - 3.9e-06 26.7 1.1 0.00026 20.9 0.2 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK37503.1 - 0.0046 16.9 2.1 0.17 11.9 0.2 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37503.1 - 0.0088 15.8 0.2 0.0088 15.8 0.2 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK37503.1 - 0.34 10.7 3.5 2 8.2 0.4 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK37503.1 - 1.3 8.8 9.4 2.1 8.2 0.0 3.1 2 1 1 3 3 3 0 C2H2 zinc-finger rve PF00665.26 PIK37505.1 - 2.8e-18 66.2 0.0 4.5e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37505.1 - 5.5e-06 26.1 0.1 1.4e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK37506.1 - 3.9e-31 107.5 0.1 6.8e-31 106.7 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK37506.1 - 3.4e-22 78.4 0.0 6.4e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK37506.1 - 3.5e-12 46.2 0.1 6e-12 45.5 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK37507.1 - 1.6e-07 31.1 2.7 2.5e-07 30.5 2.7 1.3 1 0 0 1 1 1 1 Zinc knuckle DNA_ligase_A_N PF04675.14 PIK37507.1 - 0.0093 16.3 0.2 0.013 15.8 0.2 1.3 1 0 0 1 1 1 1 DNA ligase N terminus zf-CCHC_6 PF15288.6 PIK37507.1 - 0.011 15.6 1.6 0.027 14.3 1.6 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37507.1 - 0.057 13.3 1.5 0.084 12.7 1.5 1.3 1 0 0 1 1 1 0 Zinc knuckle DUF3763 PF12592.8 PIK37507.1 - 0.074 13.1 0.4 0.15 12.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) NPFF PF15085.6 PIK37507.1 - 0.083 13.2 0.1 0.47 10.8 0.0 2.0 2 0 0 2 2 2 0 Neuropeptide FF Band_7_1 PF13421.6 PIK37507.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 SPFH domain-Band 7 family SapA PF02199.15 PIK37508.1 - 0.11 12.8 0.6 0.21 11.9 0.6 1.4 1 0 0 1 1 1 0 Saposin A-type domain gag-asp_proteas PF13975.6 PIK37509.1 - 6.9e-09 36.1 0.0 4.6e-08 33.5 0.0 2.3 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK37509.1 - 3.5e-07 30.8 0.1 1.3e-06 29.0 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 PIK37509.1 - 4.5e-05 23.7 0.0 0.00014 22.1 0.0 1.9 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK37509.1 - 0.0056 16.5 0.0 0.0099 15.7 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVT_1 PF00078.27 PIK37509.1 - 0.019 14.5 0.1 0.048 13.2 0.0 1.7 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pecanex_C PF05041.15 PIK37510.1 - 4.4e-82 275.1 0.1 5.4e-82 274.8 0.1 1.1 1 0 0 1 1 1 1 Pecanex protein (C-terminus) BRCA2 PF00634.18 PIK37511.1 - 3.4e-50 167.4 24.4 6.5e-10 38.5 0.7 8.0 7 1 1 8 8 8 7 BRCA2 repeat BRCA-2_helical PF09169.10 PIK37511.1 - 1.7e-21 76.7 0.0 4.2e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 BRCA2, helical DUF1912 PF08930.10 PIK37511.1 - 1.6e-05 25.0 0.5 2 8.6 0.0 5.5 7 0 0 7 7 7 1 Domain of unknown function (DUF1912) KCNQC3-Ank-G_bd PF11956.8 PIK37511.1 - 0.013 15.7 0.1 0.042 14.1 0.1 1.9 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 Pep3_Vps18 PF05131.14 PIK37511.1 - 0.024 14.5 0.1 0.059 13.2 0.1 1.7 1 0 0 1 1 1 0 Pep3/Vps18/deep orange family BRCA2 PF00634.18 PIK37512.1 - 4.3e-39 131.9 11.5 1.4e-06 27.8 0.9 7.9 7 0 0 7 7 7 7 BRCA2 repeat DUF4174 PF13778.6 PIK37513.1 - 0.016 15.7 1.5 0.046 14.2 1.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) OTU PF02338.19 PIK37515.1 - 1.9e-06 28.4 0.0 5e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease T6SS-SciN PF12790.7 PIK37515.1 - 0.14 11.9 0.1 0.39 10.4 0.1 1.7 2 0 0 2 2 2 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 RNA_pol_L_2 PF13656.6 PIK37516.1 - 7.6e-31 105.7 0.0 9.7e-31 105.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 PIK37516.1 - 1.1e-14 53.6 0.0 1.5e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DHHC PF01529.20 PIK37517.1 - 4.6e-25 88.3 14.5 4.6e-25 88.3 14.5 3.1 2 2 1 3 3 3 1 DHHC palmitoyltransferase DUF1689 PF07954.11 PIK37517.1 - 1.4 9.3 4.4 0.4 11.1 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1689) ESSS PF10183.9 PIK37517.1 - 9.8 6.4 7.0 13 6.0 1.5 3.0 2 1 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ank_2 PF12796.7 PIK37518.1 - 2.2e-30 105.1 0.0 9.3e-12 45.4 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK37518.1 - 4.7e-25 87.6 0.9 3e-08 34.0 0.1 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK37518.1 - 2.5e-23 79.6 0.7 1.1e-05 25.4 0.0 5.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK37518.1 - 2e-20 72.5 1.3 6.7e-05 23.1 0.0 4.3 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK37518.1 - 1e-19 70.0 0.7 0.0004 20.7 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat CD36 PF01130.21 PIK37519.1 - 5.6e-118 394.4 0.0 6.8e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 CD36 family SDA1 PF05285.12 PIK37519.1 - 0.0075 15.7 11.7 0.0086 15.5 11.7 1.1 1 0 0 1 1 1 1 SDA1 Pes-10 PF07149.11 PIK37519.1 - 0.17 10.9 11.4 0.22 10.5 11.4 1.1 1 0 0 1 1 1 0 Pes-10 CD36 PF01130.21 PIK37520.1 - 6.5e-131 437.1 0.0 7.7e-131 436.8 0.0 1.0 1 0 0 1 1 1 1 CD36 family TMEMspv1-c74-12 PF11044.8 PIK37520.1 - 0.12 12.4 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein ADD_ATRX PF17981.1 PIK37521.1 - 2.3e-18 65.8 2.0 7.5e-18 64.2 2.0 1.9 1 0 0 1 1 1 1 Cysteine Rich ADD domain SNF2_N PF00176.23 PIK37522.1 - 9.5e-05 21.3 1.2 0.00013 20.8 0.1 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain zf-MYND PF01753.18 PIK37523.1 - 0.0053 16.8 18.5 0.0091 16.1 18.5 1.4 1 0 0 1 1 1 1 MYND finger LMBR1 PF04791.16 PIK37523.1 - 0.0061 15.5 3.4 0.0077 15.2 3.4 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Bromodomain PF00439.25 PIK37524.1 - 1.3e-19 70.0 0.1 5.8e-19 68.0 0.0 2.2 2 0 0 2 2 2 1 Bromodomain PWWP PF00855.17 PIK37524.1 - 3.2e-08 33.8 1.2 1.5e-07 31.7 0.1 2.8 2 0 0 2 2 2 1 PWWP domain Efg1 PF10153.9 PIK37524.1 - 0.037 14.4 11.6 0.024 15.0 8.0 2.5 2 0 0 2 2 2 0 rRNA-processing protein Efg1 CDRT4 PF15213.6 PIK37524.1 - 0.38 11.4 6.2 0.07 13.7 0.9 2.5 2 1 0 2 2 2 0 CMT1A duplicated region transcript 4 protein TRAM_LAG1_CLN8 PF03798.16 PIK37525.1 - 2.6e-12 46.9 17.9 3.8e-12 46.4 17.9 1.3 1 0 0 1 1 1 1 TLC domain FtsX PF02687.21 PIK37525.1 - 2.4 8.7 11.3 8.3 7.0 0.3 3.4 3 1 1 4 4 4 0 FtsX-like permease family MtN3_slv PF03083.16 PIK37526.1 - 1.2e-47 159.9 15.7 5.7e-25 87.2 2.9 2.2 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 PIK37526.1 - 0.015 15.4 5.5 0.034 14.2 0.4 2.9 2 1 1 3 3 3 0 Lipid A Biosynthesis N-terminal domain NnrS PF05940.12 PIK37526.1 - 0.17 11.2 7.5 0.22 10.8 0.4 2.0 1 1 1 2 2 2 0 NnrS protein PQ-loop PF04193.14 PIK37526.1 - 0.28 11.0 0.1 0.28 11.0 0.1 4.0 5 1 0 5 5 5 0 PQ loop repeat GPR_Gpa2_C PF11970.8 PIK37527.1 - 0.023 14.8 0.4 17 5.5 0.0 3.2 3 1 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term TrbC PF04956.13 PIK37527.1 - 0.59 10.4 6.1 0.89 9.8 2.8 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family Methyltransf_23 PF13489.6 PIK37528.1 - 1.8e-10 40.9 0.0 3.6e-10 39.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK37528.1 - 0.00068 20.3 0.0 0.0017 19.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37528.1 - 0.022 14.6 0.1 0.055 13.3 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37528.1 - 0.095 13.4 0.0 0.19 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK37528.1 - 0.15 12.8 0.3 7.4 7.3 0.1 2.7 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK37529.1 - 7.2e-12 45.4 0.0 1.1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK37529.1 - 2e-05 25.2 0.0 3.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37529.1 - 0.0018 18.1 0.0 0.0042 16.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37529.1 - 0.017 15.9 0.0 0.059 14.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK37529.1 - 0.12 13.0 0.1 0.53 11.0 0.0 2.2 2 2 0 2 2 2 0 Methyltransferase domain LMWPc PF01451.21 PIK37531.1 - 1.4e-13 51.4 0.0 1.7e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Phage_ASH PF10554.9 PIK37531.1 - 0.0012 19.2 0.0 0.0021 18.4 0.0 1.5 1 1 0 1 1 1 1 Ash protein family DFP PF04127.15 PIK37531.1 - 0.022 14.6 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein FAM199X PF15814.5 PIK37532.1 - 8.6e-10 38.2 7.5 1.4e-06 27.6 0.4 2.2 1 1 1 2 2 2 2 Protein family FAM199X Peptidase_M41 PF01434.18 PIK37533.1 - 2e-57 194.2 0.6 2.6e-42 144.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M41 AAA PF00004.29 PIK37533.1 - 3.9e-39 134.1 0.0 1.1e-38 132.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK37533.1 - 8.2e-12 44.7 1.5 8.7e-12 44.7 0.2 1.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 PIK37533.1 - 0.00047 20.2 0.0 0.0012 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK37533.1 - 0.00063 20.2 0.0 0.019 15.3 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 PIK37533.1 - 0.0024 17.6 0.0 0.0064 16.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 PIK37533.1 - 0.0053 16.0 0.0 0.013 14.7 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 PIK37533.1 - 0.012 16.2 0.0 0.035 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK37533.1 - 0.015 15.6 0.0 0.27 11.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK37533.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 PIK37533.1 - 0.088 12.5 0.1 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein FumaraseC_C PF10415.9 PIK37533.1 - 0.089 13.2 0.9 0.38 11.2 0.9 2.1 1 0 0 1 1 1 0 Fumarase C C-terminus Mg_chelatase PF01078.21 PIK37533.1 - 0.099 12.0 0.2 0.43 9.9 0.2 2.0 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 PIK37533.1 - 0.17 11.4 0.0 0.59 9.6 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region zf-CCHC PF00098.23 PIK37534.1 - 7.7e-10 38.4 12.5 0.002 18.1 0.7 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_5 PF14787.6 PIK37534.1 - 0.044 13.5 0.6 0.044 13.5 0.6 3.2 1 1 2 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK37534.1 - 0.055 13.4 16.8 0.48 10.4 1.0 3.5 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK37534.1 - 1.2 9.0 7.3 12 5.8 2.7 2.8 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK37534.1 - 4.2 7.2 13.9 0.22 11.3 0.9 3.7 2 2 2 4 4 4 0 Zinc knuckle WD40 PF00400.32 PIK37535.1 - 2.4e-10 40.8 5.6 0.065 14.1 0.0 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37535.1 - 7.5e-06 26.2 0.1 0.0048 17.2 0.0 4.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 PIK37536.1 - 0.0015 18.2 0.8 0.072 12.7 0.8 2.8 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 PIK37536.1 - 0.014 15.4 3.1 0.072 13.1 0.0 2.8 3 0 0 3 3 3 0 Prp18 domain SRA1 PF07304.11 PIK37536.1 - 0.019 14.8 0.0 0.019 14.8 0.0 3.0 3 0 0 3 3 3 0 Steroid receptor RNA activator (SRA1) PhzC-PhzF PF02567.16 PIK37537.1 - 1.7e-43 149.1 0.0 2.6e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein PfkB PF00294.24 PIK37538.1 - 1.1e-66 225.2 0.0 1.3e-66 225.0 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TGT_C2 PF14810.6 PIK37538.1 - 0.087 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Patch-forming domain C2 of tRNA-guanine transglycosylase PfkB PF00294.24 PIK37539.1 - 1.7e-65 221.3 0.1 2.3e-65 220.9 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Tma16 PF11176.8 PIK37540.1 - 5.1e-37 127.0 7.1 7.6e-37 126.4 7.1 1.3 1 0 0 1 1 1 1 Translation machinery-associated protein 16 EF-hand_8 PF13833.6 PIK37541.1 - 0.016 15.0 0.1 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 PIK37541.1 - 0.044 14.2 0.1 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair ANAPC10 PF03256.16 PIK37542.1 - 4.1e-11 42.9 0.2 1.6e-10 41.0 0.2 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK37542.1 - 0.001 19.2 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain zf-CCCH PF00642.24 PIK37543.1 - 3.8e-13 49.0 31.5 1.1e-05 25.2 0.3 4.7 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK37543.1 - 8.9e-13 47.8 42.4 6.5e-07 29.2 1.7 6.1 5 1 0 5 5 5 4 Zinc finger domain Torus PF16131.5 PIK37543.1 - 5e-10 40.0 19.6 0.00011 22.8 0.5 4.4 1 1 3 4 4 4 4 Torus domain zf-CCCH_3 PF15663.5 PIK37543.1 - 1.1e-06 28.8 19.4 0.00035 20.7 5.0 2.4 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 PIK37543.1 - 1.9e-05 24.3 0.3 1.9e-05 24.3 0.3 4.6 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCHC PF00098.23 PIK37543.1 - 0.0012 18.8 1.7 0.0012 18.8 1.7 3.0 3 0 0 3 3 3 1 Zinc knuckle zf-CCCH_2 PF14608.6 PIK37543.1 - 0.0027 18.1 46.6 0.012 16.1 2.8 6.0 6 1 0 6 6 6 3 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.9 PIK37543.1 - 0.04 13.6 0.4 0.04 13.6 0.4 5.3 6 0 0 6 6 6 0 Putative zinc-finger domain zf-C2H2_10 PF16588.5 PIK37543.1 - 0.061 13.1 1.7 0.26 11.0 1.7 2.1 1 0 0 1 1 1 0 C2H2 zinc-finger Herpes_heli_pri PF05774.11 PIK37543.1 - 0.091 13.0 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component zf-CCHC_2 PF13696.6 PIK37543.1 - 4.4 7.2 17.5 0.12 12.2 5.7 3.4 3 0 0 3 3 3 0 Zinc knuckle Rpr2 PF04032.16 PIK37544.1 - 5e-19 68.4 1.3 8e-19 67.7 1.3 1.5 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Peptidase_M44 PF03410.13 PIK37544.1 - 0.014 14.0 0.1 0.016 13.8 0.1 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox ADD_ATRX PF17981.1 PIK37544.1 - 0.024 14.5 2.6 3.4 7.6 0.3 2.5 2 0 0 2 2 2 0 Cysteine Rich ADD domain SIR2 PF02146.17 PIK37544.1 - 0.025 14.5 0.2 0.031 14.2 0.2 1.2 1 0 0 1 1 1 0 Sir2 family zf-C2H2_3 PF13878.6 PIK37544.1 - 0.91 9.4 6.3 0.85 9.5 0.2 3.1 2 1 1 3 3 3 0 zinc-finger of acetyl-transferase ESCO UbiA PF01040.18 PIK37545.1 - 1.3e-50 172.0 20.6 1.3e-50 172.0 20.6 1.5 2 0 0 2 2 2 1 UbiA prenyltransferase family LRR_8 PF13855.6 PIK37545.1 - 3.3e-24 84.4 24.8 1.2e-12 47.4 0.2 3.5 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK37545.1 - 1.8e-10 40.9 16.9 0.00031 21.0 2.5 4.2 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK37545.1 - 2.3e-05 24.3 13.1 0.098 13.3 0.2 5.9 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK37545.1 - 0.00011 22.2 0.0 0.00025 21.0 0.0 1.5 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37545.1 - 0.00027 20.5 5.0 0.073 12.6 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK37545.1 - 0.014 15.4 11.8 1.1 9.5 0.1 5.4 5 0 0 5 5 5 0 Leucine Rich repeat Aminotran_5 PF00266.19 PIK37546.1 - 1.1e-32 113.4 0.0 1.9e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.20 PIK37547.1 - 1.4e-09 37.9 0.0 3.2e-09 36.8 0.0 1.6 2 0 0 2 2 2 1 PP-loop family RanGAP1_C PF07834.11 PIK37548.1 - 2.5e-23 82.6 0.0 4.1e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.6 PIK37548.1 - 1.6e-17 61.9 1.5 0.035 14.1 0.0 8.1 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.7 PIK37548.1 - 0.0062 16.9 0.4 92 3.7 0.1 4.6 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) YL1 PF05764.13 PIK37548.1 - 0.11 12.6 3.6 0.16 12.0 3.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein ThaI PF15514.6 PIK37548.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease ThaI NOA36 PF06524.12 PIK37548.1 - 2.4 7.4 6.6 3.9 6.7 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein EF-hand_8 PF13833.6 PIK37549.1 - 1.7e-08 34.1 1.0 4.2e-08 32.9 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 PIK37549.1 - 5.2e-07 30.0 0.2 1.8e-06 28.3 0.2 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK37549.1 - 1.7e-05 24.0 1.0 0.0067 15.9 0.0 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 PIK37549.1 - 0.00096 18.9 0.2 0.068 13.1 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_10 PF14788.6 PIK37549.1 - 0.0035 17.2 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 EF hand DIX PF00778.17 PIK37549.1 - 0.049 13.5 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 DIX domain EF-hand_5 PF13202.6 PIK37549.1 - 0.095 12.2 0.0 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 EF hand EF-hand_4 PF12763.7 PIK37549.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand WD40 PF00400.32 PIK37550.1 - 5.4e-05 23.9 0.3 0.26 12.2 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 PIK37550.1 - 0.004 16.0 0.1 0.013 14.3 0.0 1.7 1 1 1 2 2 2 1 Nup133 N terminal like WD40 PF00400.32 PIK37551.1 - 5.8e-05 23.8 0.3 0.23 12.4 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 PIK37551.1 - 0.0077 15.0 0.1 0.029 13.1 0.0 1.7 1 1 0 2 2 2 1 Nup133 N terminal like Cluap1 PF10234.9 PIK37552.1 - 3.4e-113 377.5 11.3 5.1e-113 376.9 11.3 1.3 1 0 0 1 1 1 1 Clusterin-associated protein-1 Lebercilin PF15619.6 PIK37552.1 - 0.00054 19.7 17.6 0.00091 18.9 17.6 1.3 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Glyco_hydro_4C PF11975.8 PIK37552.1 - 0.0084 16.2 2.1 0.016 15.3 2.1 1.5 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain NPV_P10 PF05531.12 PIK37552.1 - 0.025 15.1 5.7 0.19 12.2 0.7 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.15 PIK37552.1 - 0.15 12.5 19.1 0.28 11.6 18.7 1.6 1 1 1 2 2 2 0 Fez1 DUF489 PF04356.12 PIK37552.1 - 0.24 11.4 4.1 0.14 12.1 1.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Exonuc_VII_L PF02601.15 PIK37552.1 - 0.28 10.7 14.3 0.41 10.2 14.3 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Tweety PF04906.13 PIK37552.1 - 0.66 8.6 6.9 0.25 10.0 0.9 2.2 1 1 1 2 2 2 0 Tweety Prominin PF05478.11 PIK37552.1 - 0.71 7.8 6.0 0.97 7.3 6.0 1.3 1 0 0 1 1 1 0 Prominin Bacillus_HBL PF05791.11 PIK37552.1 - 1 9.1 10.8 1.7 8.4 3.5 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Alb1 PF09135.11 PIK37552.1 - 1.1 10.1 9.2 0.095 13.6 2.5 2.3 1 1 0 2 2 2 0 Alb1 SLATT_5 PF18160.1 PIK37552.1 - 2.1 7.6 6.9 3.8 6.8 6.9 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 FadA PF09403.10 PIK37552.1 - 2.1 8.9 23.1 0.3 11.6 5.5 3.2 1 1 2 3 3 3 0 Adhesion protein FadA Atg14 PF10186.9 PIK37552.1 - 2.2 7.3 11.3 3.5 6.6 11.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 PIK37552.1 - 2.2 8.6 22.6 2.1 8.7 10.3 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF1043 PF06295.12 PIK37552.1 - 2.7 8.0 12.6 2.6e+02 1.6 12.6 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Noelin-1 PF12308.8 PIK37552.1 - 3 7.9 7.0 1.7 8.7 1.1 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein COG2 PF06148.11 PIK37552.1 - 4.6 7.3 11.9 15 5.7 4.3 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 PIK37552.1 - 4.8 6.0 22.7 5.8 5.7 7.9 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 PIK37552.1 - 5.4 6.5 17.8 1.7 8.1 14.8 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DASH_Spc19 PF08287.11 PIK37552.1 - 6 6.7 21.2 2.1 8.2 9.2 2.7 2 1 1 3 3 3 0 Spc19 DUF948 PF06103.11 PIK37552.1 - 6.3 7.1 5.9 8.5 6.7 0.7 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 PIK37552.1 - 7.7 6.7 21.3 8.5 6.6 20.0 1.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliD_N PF02465.18 PIK37552.1 - 8.3 7.2 16.8 3.5 8.4 3.3 3.3 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus TMPIT PF07851.13 PIK37552.1 - 9.1 5.4 16.3 4.8 6.3 5.6 2.2 1 1 1 2 2 2 0 TMPIT-like protein DUF4407 PF14362.6 PIK37552.1 - 9.2 5.5 12.3 7.2 5.9 10.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fzo_mitofusin PF04799.13 PIK37552.1 - 9.9 5.7 9.6 0.3 10.6 1.8 2.2 2 0 0 2 2 2 0 fzo-like conserved region BLUF PF04940.12 PIK37553.1 - 0.0019 18.3 0.1 0.0064 16.6 0.1 1.9 1 1 0 1 1 1 1 Sensors of blue-light using FAD zf-3CxxC_2 PF17180.4 PIK37554.1 - 1.7e-26 92.7 6.9 2.2e-26 92.3 6.9 1.2 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC PF13695.6 PIK37554.1 - 0.0003 21.2 15.4 0.021 15.3 15.4 2.6 1 1 0 1 1 1 1 Zinc-binding domain UPF0515 PF15135.6 PIK37554.1 - 0.0015 18.0 5.3 0.0017 17.7 5.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 Cytochrom_c3_2 PF14537.6 PIK37554.1 - 0.014 15.8 5.7 0.022 15.2 5.7 1.2 1 0 0 1 1 1 0 Cytochrome c3 zf_UBZ PF18439.1 PIK37554.1 - 0.59 9.8 8.1 19 5.0 0.3 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn_clus PF00172.18 PIK37554.1 - 7.3 6.8 16.6 0.72 10.0 1.5 3.1 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Sel1 PF08238.12 PIK37555.1 - 0.003 18.2 0.3 0.0043 17.7 0.3 1.3 1 0 0 1 1 1 1 Sel1 repeat CDC45 PF02724.14 PIK37556.1 - 0.52 8.5 13.9 0.64 8.2 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 PIK37556.1 - 0.8 9.0 4.7 1.1 8.5 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 PIK37556.1 - 5.2 7.1 5.9 9.5 6.2 5.9 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ETRAMP PF09716.10 PIK37557.1 - 6.2e-06 26.2 0.2 1.6e-05 24.9 0.2 1.6 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) SNAD1 PF18744.1 PIK37557.1 - 0.0021 18.0 0.4 0.0038 17.1 0.4 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 1 Ureide_permease PF07168.11 PIK37557.1 - 0.027 13.3 0.1 0.031 13.1 0.1 1.2 1 0 0 1 1 1 0 Ureide permease HECT PF00632.25 PIK37558.1 - 2.8e-11 43.5 0.0 3.1e-11 43.3 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) APH PF01636.23 PIK37559.1 - 3.4e-11 43.5 0.0 4.4e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK37559.1 - 1.1e-05 25.1 0.1 2e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 PIK37559.1 - 9.8e-05 21.4 0.0 0.00012 21.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH_6_hur PF04655.14 PIK37559.1 - 0.0093 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase EcKinase PF02958.20 PIK37559.1 - 0.095 12.0 0.3 0.29 10.4 0.3 1.7 1 1 0 1 1 1 0 Ecdysteroid kinase HALZ PF02183.18 PIK37559.1 - 0.29 11.4 1.5 3.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper APH PF01636.23 PIK37560.1 - 5.5e-10 39.6 0.0 8.2e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 PIK37560.1 - 0.0063 15.8 0.1 0.024 13.8 0.1 1.8 1 1 0 1 1 1 1 Fructosamine kinase EcKinase PF02958.20 PIK37560.1 - 0.018 14.4 0.6 0.12 11.7 0.5 2.3 1 1 0 1 1 1 0 Ecdysteroid kinase APH_6_hur PF04655.14 PIK37560.1 - 0.21 10.9 0.0 0.52 9.7 0.0 1.7 1 1 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase HECT PF00632.25 PIK37561.1 - 0.087 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) rve PF00665.26 PIK37562.1 - 3.7e-07 30.3 0.0 7.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MG3 PF17791.1 PIK37563.1 - 7.5e-14 51.8 0.0 7e-13 48.7 0.0 2.4 3 0 0 3 3 3 1 Macroglobulin domain MG3 MG2 PF01835.19 PIK37563.1 - 7.6e-06 26.3 0.0 2.7e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 MG2 domain MG4 PF17789.1 PIK37563.1 - 0.033 14.3 0.1 0.079 13.1 0.1 1.7 1 0 0 1 1 1 0 Macroglobulin domain MG4 TED_complement PF07678.14 PIK37564.1 - 5.1e-23 81.6 0.4 7.2e-23 81.1 0.4 1.1 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_recep PF07677.14 PIK37564.1 - 1.1e-20 74.1 0.2 2.3e-20 73.1 0.2 1.6 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain NTR PF01759.21 PIK37564.1 - 3.5e-16 58.9 0.1 8.5e-16 57.7 0.1 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_BRD PF07703.14 PIK37565.1 - 5.1e-22 78.7 0.0 1.2e-21 77.5 0.0 1.7 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain MG4 PF17789.1 PIK37565.1 - 1.2e-10 41.3 0.1 2.7e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 Macroglobulin domain MG4 Fibrinogen_C PF00147.18 PIK37566.1 - 5.1e-62 209.5 3.3 6e-62 209.3 3.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain 5_nucleotid_C PF02872.18 PIK37567.1 - 1.1e-45 155.7 0.0 1.8e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK37567.1 - 4.3e-13 50.2 0.0 7.7e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LRAT PF04970.13 PIK37568.1 - 2.9e-10 40.5 1.0 2.5e-08 34.3 1.0 2.4 1 1 0 1 1 1 1 Lecithin retinol acyltransferase GFA PF04828.14 PIK37568.1 - 0.0032 17.8 2.2 0.045 14.1 0.2 2.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Yip1 PF04893.17 PIK37568.1 - 0.039 13.7 2.2 2.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Yip1 domain DUF456 PF04306.13 PIK37568.1 - 0.075 13.3 0.7 0.075 13.3 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF456) LRAT PF04970.13 PIK37569.1 - 1.9e-10 41.1 0.9 1.2e-08 35.3 0.9 2.5 1 1 0 1 1 1 1 Lecithin retinol acyltransferase REC104 PF17378.2 PIK37570.1 - 0.00072 19.4 2.8 0.0016 18.3 2.8 1.5 1 0 0 1 1 1 1 Meiotic recombination protein REC104 MSP7_C PF12948.7 PIK37570.1 - 2.3 8.9 7.3 0.21 12.3 2.0 2.0 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain MFS_1 PF07690.16 PIK37571.1 - 6e-05 22.1 4.7 0.00011 21.3 3.4 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Reticulon PF02453.17 PIK37571.1 - 0.056 13.4 0.0 0.056 13.4 0.0 1.6 2 0 0 2 2 2 0 Reticulon MFS_4 PF06779.14 PIK37572.1 - 0.019 14.3 0.2 0.02 14.2 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB MIF4G PF02854.19 PIK37573.1 - 4.9e-34 117.8 5.9 4.9e-34 117.8 5.9 2.7 3 1 0 3 3 3 1 MIF4G domain W2 PF02020.18 PIK37573.1 - 6e-18 64.8 1.0 1.5e-17 63.5 0.3 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.17 PIK37573.1 - 0.00032 20.7 3.1 0.00035 20.5 0.2 2.5 2 0 0 2 2 2 1 MA3 domain ALC PF17527.2 PIK37573.1 - 0.21 11.2 1.6 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Phage ALC protein NINJA_B PF16136.5 PIK37573.1 - 8.9 6.7 7.0 23 5.4 7.0 1.7 1 0 0 1 1 1 0 Putative nuclear localisation signal PDZ PF00595.24 PIK37576.1 - 7.5e-06 26.2 0.0 9.6e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK37576.1 - 0.0012 18.6 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK37576.1 - 0.026 14.8 0.0 0.033 14.5 0.0 1.2 1 0 0 1 1 1 0 PDZ domain PGM_PMM_III PF02880.16 PIK37576.1 - 0.17 12.1 0.1 0.26 11.5 0.1 1.3 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III TauD PF02668.16 PIK37578.1 - 9.7e-37 127.2 0.1 1.9e-36 126.2 0.0 1.4 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK37578.1 - 8e-13 48.8 2.8 1.2e-10 41.8 0.4 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF971) CsiD PF08943.10 PIK37578.1 - 0.016 14.3 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 CsiD LIM PF00412.22 PIK37579.1 - 4.8e-45 151.6 59.4 5.8e-16 58.5 5.4 5.1 5 0 0 5 5 5 5 LIM domain Lamp PF01299.17 PIK37580.1 - 3.1e-06 27.1 0.0 5.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) Pox_I5 PF04713.12 PIK37580.1 - 0.019 15.0 0.1 0.032 14.3 0.1 1.4 1 0 0 1 1 1 0 Poxvirus protein I5 HepII_C PF18675.1 PIK37580.1 - 0.069 13.2 0.8 0.23 11.6 0.5 2.0 1 1 1 2 2 2 0 Heparinase II C-terminal domain PetL PF05115.14 PIK37580.1 - 0.24 11.4 3.3 0.54 10.3 3.3 1.5 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit VI (PetL) DUF3456 PF11938.8 PIK37581.1 - 1.9e-06 28.5 5.4 0.00013 22.5 0.1 3.7 3 2 1 4 4 4 2 TLR4 regulator and MIR-interacting MSAP EGF_CA PF07645.15 PIK37581.1 - 2.5e-06 27.6 32.7 0.00014 22.0 12.1 6.2 3 2 2 5 5 5 2 Calcium-binding EGF domain EGF PF00008.27 PIK37581.1 - 0.00053 20.2 4.9 0.00053 20.2 4.9 5.0 3 2 0 3 3 3 2 EGF-like domain cEGF PF12662.7 PIK37581.1 - 0.00058 19.7 1.6 0.00058 19.7 1.6 6.0 6 1 0 6 6 6 3 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK37581.1 - 0.0014 18.8 10.7 0.0014 18.8 10.7 6.8 2 1 4 6 6 6 1 Laminin EGF domain FXa_inhibition PF14670.6 PIK37581.1 - 0.012 15.9 8.4 0.012 15.9 8.4 6.8 2 2 3 5 5 5 0 Coagulation Factor Xa inhibitory site tRNA-synt_1 PF00133.22 PIK37582.1 - 4.4e-220 732.0 1.4 7.5e-220 731.2 1.4 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 PIK37582.1 - 1.4e-27 96.5 0.0 2.8e-27 95.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 PIK37582.1 - 6.7e-15 54.7 2.2 3.3e-05 22.8 0.1 3.9 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 PIK37582.1 - 0.00028 20.3 0.0 0.0051 16.2 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Kelch_6 PF13964.6 PIK37583.1 - 4.5e-19 68.0 4.6 2.4e-07 30.8 0.0 4.6 4 1 1 5 5 5 4 Kelch motif Kelch_4 PF13418.6 PIK37583.1 - 4.8e-18 64.9 4.5 4.2e-07 29.9 0.0 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 PIK37583.1 - 5.3e-16 57.9 3.5 0.00073 19.1 0.0 4.6 4 1 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 PIK37583.1 - 1e-13 50.9 8.3 1.1e-06 28.5 0.0 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 PIK37583.1 - 1.2e-12 47.8 7.5 0.0046 17.2 0.0 5.2 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK37583.1 - 4.4e-12 45.5 6.7 0.00041 20.2 0.1 4.5 4 1 0 4 4 4 2 Kelch motif PQQ_3 PF13570.6 PIK37583.1 - 0.051 14.1 0.2 25 5.5 0.0 3.6 4 0 0 4 4 4 0 PQQ-like domain rve PF00665.26 PIK37584.1 - 1.7e-23 83.1 0.0 2.2e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37584.1 - 7.7e-06 25.6 0.1 1.7e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK37584.1 - 0.0065 16.7 0.1 0.0092 16.2 0.1 1.1 1 0 0 1 1 1 1 DDE domain RVT_1 PF00078.27 PIK37585.1 - 1.6e-26 93.2 0.0 2.5e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Brix PF04427.18 PIK37586.1 - 2e-18 67.2 2.3 2e-18 67.2 2.3 1.5 2 0 0 2 2 2 1 Brix domain Y_phosphatase PF00102.27 PIK37587.1 - 3.6e-128 426.0 6.4 2.3e-73 246.7 4.6 2.7 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK37587.1 - 5e-21 74.8 18.7 7.3e-05 23.0 0.0 8.9 7 2 0 7 7 7 5 Fibronectin type III domain DSPc PF00782.20 PIK37587.1 - 1.4e-08 34.7 0.2 0.0018 18.1 0.1 2.8 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK37587.1 - 8.6e-05 22.6 0.0 0.092 12.7 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family UPF0560 PF10577.9 PIK37587.1 - 0.00051 18.7 2.1 0.0014 17.3 1.9 1.5 1 1 0 1 1 1 1 Uncharacterised protein family UPF0560 Glycophorin_A PF01102.18 PIK37587.1 - 0.00086 19.5 0.3 0.0035 17.6 0.3 2.0 1 0 0 1 1 1 1 Glycophorin A PTPlike_phytase PF14566.6 PIK37587.1 - 0.004 17.3 0.1 0.19 11.9 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate TMEM154 PF15102.6 PIK37587.1 - 0.014 15.3 1.3 0.014 15.3 1.3 2.2 2 0 0 2 2 2 0 TMEM154 protein family Stevor PF17410.2 PIK37587.1 - 0.025 14.2 3.3 0.027 14.0 0.6 2.2 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame LPG_synthase_TM PF03706.13 PIK37587.1 - 0.04 13.4 0.0 0.063 12.8 0.0 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Cadherin_C_2 PF16492.5 PIK37587.1 - 0.048 14.4 0.1 1.2 9.9 0.0 2.8 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal CD34_antigen PF06365.12 PIK37587.1 - 0.087 12.4 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family GSHPx PF00255.19 PIK37587.1 - 0.088 12.4 0.5 0.3 10.7 0.1 2.0 2 0 0 2 2 2 0 Glutathione peroxidase Interfer-bind PF09294.10 PIK37587.1 - 0.11 12.8 3.1 23 5.4 0.0 4.3 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III Adeno_E3_CR2 PF02439.15 PIK37587.1 - 0.16 11.7 6.2 0.39 10.5 6.2 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CD45 PF12567.8 PIK37587.1 - 1.6 8.7 4.1 41 4.2 0.1 4.2 5 0 0 5 5 5 0 Leukocyte receptor CD45 Acyl-CoA_dh_N PF02771.16 PIK37588.1 - 4.5e-27 94.9 0.0 7.4e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 PIK37588.1 - 1.4e-26 93.5 0.2 2.5e-26 92.7 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK37588.1 - 2.4e-12 46.9 0.0 5.3e-12 45.8 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK37588.1 - 0.0062 16.8 0.0 0.018 15.3 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PHR PF08005.12 PIK37589.1 - 8.1e-06 26.6 0.0 1.4e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 PHR domain Filamin PF00630.19 PIK37590.1 - 1.1e-07 32.6 0.0 1.6e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Filamin/ABP280 repeat Invasin_D3 PF09134.10 PIK37590.1 - 0.11 12.8 0.1 0.5 10.7 0.0 1.9 2 0 0 2 2 2 0 Invasin, domain 3 SH3_3 PF08239.11 PIK37591.1 - 1.1e-12 48.0 0.0 3.2e-06 27.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain zf-RING_2 PF13639.6 PIK37591.1 - 3e-07 30.7 9.1 3e-07 30.7 9.1 5.6 5 0 0 5 5 5 1 Ring finger domain ANAPC10 PF03256.16 PIK37591.1 - 8.4e-07 28.8 0.1 1.6e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-RING_UBOX PF13445.6 PIK37591.1 - 0.0065 16.5 4.4 0.0065 16.5 4.4 5.0 6 0 0 6 6 6 1 RING-type zinc-finger zf-RING_11 PF17123.5 PIK37591.1 - 2.3 8.0 19.6 0.049 13.4 10.0 3.2 2 0 0 2 2 2 0 RING-like zinc finger tRNA-synt_His PF13393.6 PIK37592.1 - 3.4e-41 141.5 0.0 1.1e-40 139.9 0.0 1.8 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 PIK37592.1 - 3.5e-08 33.5 0.0 9.2e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 PIK37592.1 - 2.4e-05 24.0 0.0 7.8e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 PIK37592.1 - 6.8e-05 22.9 0.0 0.00018 21.5 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 PIK37592.1 - 0.00043 20.4 0.1 0.0018 18.4 0.1 2.1 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2 PF00152.20 PIK37592.1 - 0.0034 16.5 0.0 0.011 14.8 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) Ets PF00178.22 PIK37593.1 - 3.8e-35 120.2 0.4 6.4e-35 119.5 0.4 1.4 1 0 0 1 1 1 1 Ets-domain Thiolase_N PF00108.23 PIK37593.1 - 0.014 14.8 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Thiolase, N-terminal domain G-alpha PF00503.20 PIK37594.1 - 1.4e-37 129.7 0.0 2.1e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK37594.1 - 2.1e-09 37.1 0.0 3.4e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TMEM154 PF15102.6 PIK37594.1 - 0.00022 21.1 13.8 0.00022 21.1 13.8 4.3 1 1 2 3 3 1 1 TMEM154 protein family Orf78 PF06024.12 PIK37594.1 - 0.0013 19.0 5.4 0.0013 19.0 5.4 4.1 1 1 1 2 2 1 1 Orf78 (ac78) LRRC37AB_C PF14914.6 PIK37594.1 - 0.0069 16.3 6.4 0.0069 16.3 6.4 4.3 1 1 2 3 3 1 1 LRRC37A/B like protein 1 C-terminal domain MID_MedPIWI PF18296.1 PIK37594.1 - 0.016 15.1 2.5 0.022 14.6 2.5 1.1 1 0 0 1 1 1 0 MID domain of medPIWI DUF1180 PF06679.12 PIK37594.1 - 0.018 15.4 2.3 0.018 15.4 2.3 2.5 1 1 1 2 2 1 0 Protein of unknown function (DUF1180) SPX PF03105.19 PIK37594.1 - 0.021 14.8 9.0 0.024 14.6 9.0 1.1 1 0 0 1 1 1 0 SPX domain DUF1676 PF07898.13 PIK37594.1 - 0.03 14.4 0.1 0.03 14.4 0.1 2.7 1 1 1 2 2 1 0 Protein of unknown function (DUF1676) POX PF07526.11 PIK37594.1 - 0.039 14.5 2.7 0.06 13.9 2.7 1.2 1 0 0 1 1 1 0 Associated with HOX Sec3_C PF09763.9 PIK37594.1 - 0.28 9.5 1.2 0.33 9.3 1.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 Apt1 PF10351.9 PIK37594.1 - 0.47 9.3 15.0 0.59 8.9 15.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 PIK37594.1 - 1.1 8.1 8.5 1.5 7.7 8.5 1.1 1 0 0 1 1 1 0 Peroxin-3 NAM-associated PF14303.6 PIK37594.1 - 2.2 9.0 9.1 2.9 8.6 9.1 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Miga PF10265.9 PIK37594.1 - 3.4 6.5 8.7 4.2 6.2 8.7 1.1 1 0 0 1 1 1 0 Mitoguardin DUF1635 PF07795.11 PIK37594.1 - 5.4 6.8 14.0 9 6.1 14.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CASP_C PF08172.12 PIK37594.1 - 5.9 6.2 6.9 10 5.4 6.9 1.3 1 0 0 1 1 1 0 CASP C terminal HSD3 PF15244.6 PIK37594.1 - 7.5 5.9 15.3 9.4 5.6 15.3 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 SelP_N PF04592.14 PIK37594.1 - 8.2 5.8 10.3 14 5.0 10.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ribonuc_P_40 PF08584.11 PIK37595.1 - 6.4e-60 202.8 0.3 3e-42 144.9 0.0 2.0 1 1 1 2 2 2 2 Ribonuclease P 40kDa (Rpp40) subunit Pkinase_Tyr PF07714.17 PIK37596.1 - 1.2e-07 31.3 0.0 2.2e-05 23.9 0.0 2.9 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK37596.1 - 2.9e-07 30.1 0.0 2.9e-06 26.9 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain LBP_BPI_CETP_C PF02886.17 PIK37597.1 - 1.7e-23 83.3 0.0 3.3e-20 72.6 0.0 2.4 2 0 0 2 2 2 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK37597.1 - 2.4e-19 69.5 0.0 4.6e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 PIK37598.1 - 9.6e-40 136.5 0.0 1.7e-39 135.7 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK37598.1 - 2.3e-05 24.1 0.0 8.7e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain JHBP PF06585.11 PIK37598.1 - 0.0014 17.9 0.0 0.0032 16.7 0.0 1.6 1 0 0 1 1 1 1 Haemolymph juvenile hormone binding protein (JHBP) Nucleolin_bd PF16725.5 PIK37598.1 - 0.002 17.7 0.4 0.0082 15.8 0.0 2.1 2 0 0 2 2 2 1 Nucleolin binding domain LBP_BPI_CETP_C PF02886.17 PIK37599.1 - 3.1e-13 49.7 0.4 5.4e-13 49.0 0.4 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain HTH_23 PF13384.6 PIK37600.1 - 0.0009 19.0 0.4 0.0024 17.6 0.0 1.9 2 1 0 2 2 2 1 Homeodomain-like domain HTH_30 PF13556.6 PIK37600.1 - 0.0033 17.2 0.7 0.0093 15.7 0.3 1.9 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain GerE PF00196.19 PIK37600.1 - 0.01 15.4 0.1 0.025 14.1 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_Tnp_ISL3 PF13542.6 PIK37600.1 - 0.017 14.5 0.0 0.042 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.12 PIK37600.1 - 0.035 13.8 0.0 0.097 12.4 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 PIK37600.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 HTH domain HECT PF00632.25 PIK37601.1 - 7.7e-15 55.2 0.0 3.9e-10 39.7 0.0 2.3 2 1 0 2 2 2 2 HECT-domain (ubiquitin-transferase) DUF4219 PF13961.6 PIK37601.1 - 0.13 12.0 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) EMC3_TMCO1 PF01956.16 PIK37602.1 - 2.2e-41 141.4 1.9 2.7e-41 141.2 1.9 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Nucleoside_tran PF01733.18 PIK37602.1 - 0.0007 19.1 1.4 0.0007 19.1 1.4 1.6 1 1 1 2 2 2 1 Nucleoside transporter DivIC PF04977.15 PIK37602.1 - 0.0078 16.0 1.8 0.015 15.0 1.8 1.4 1 0 0 1 1 1 1 Septum formation initiator MIF4G_like_2 PF09090.11 PIK37602.1 - 0.013 15.0 0.3 0.017 14.6 0.3 1.1 1 0 0 1 1 1 0 MIF4G like Anoctamin PF04547.12 PIK37602.1 - 0.03 13.2 0.5 0.043 12.7 0.1 1.4 2 0 0 2 2 2 0 Calcium-activated chloride channel DUF2828 PF11443.8 PIK37602.1 - 0.034 12.2 0.1 0.04 12.0 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Zip PF02535.22 PIK37602.1 - 0.035 13.3 0.1 0.06 12.5 0.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 PIK37602.1 - 0.06 13.1 0.4 0.093 12.5 0.4 1.2 1 0 0 1 1 1 0 Connexin Stevor PF17410.2 PIK37602.1 - 0.078 12.5 1.6 0.12 11.9 1.6 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame GWT1 PF06423.12 PIK37602.1 - 0.098 12.8 1.1 0.22 11.6 1.1 1.7 1 1 0 1 1 1 0 GWT1 Prenyltrans PF00432.21 PIK37603.1 - 5.3e-66 218.0 4.1 4.7e-13 48.6 0.0 5.8 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 PIK37603.1 - 2.1e-05 23.8 0.0 8.9e-05 21.7 0.0 2.0 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 PIK37603.1 - 0.015 14.4 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 A-macroglobulin TED domain V_ATPase_I PF01496.19 PIK37604.1 - 6.2e-257 854.6 0.0 7.8e-257 854.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family V_ATPase_I PF01496.19 PIK37605.1 - 5.2e-16 57.8 0.2 6.2e-16 57.5 0.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family V_ATPase_I PF01496.19 PIK37606.1 - 2.5e-129 432.6 0.0 3.4e-129 432.1 0.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family REPA_OB_2 PF16900.5 PIK37607.1 - 3e-05 23.9 0.4 9.1e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Replication protein A OB domain DUF3127 PF11325.8 PIK37607.1 - 0.015 15.5 0.2 0.038 14.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3127) V_ATPase_I PF01496.19 PIK37608.1 - 1.4e-192 641.8 0.0 1.6e-192 641.6 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family V_ATPase_I PF01496.19 PIK37609.1 - 3.9e-29 101.2 3.0 4e-29 101.1 3.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4212 PF13937.6 PIK37609.1 - 0.025 14.9 2.8 0.033 14.5 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) 2TM PF13239.6 PIK37609.1 - 0.5 10.7 5.4 0.7 10.2 5.4 1.4 1 1 0 1 1 1 0 2TM domain RasGEF PF00617.19 PIK37610.1 - 2.8e-11 43.9 0.0 5.3e-11 43.0 0.0 1.4 1 1 0 1 1 1 1 RasGEF domain SH2 PF00017.24 PIK37611.1 - 2.7e-16 59.4 0.1 6e-16 58.3 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SAM_1 PF00536.30 PIK37612.1 - 2.4e-06 27.9 0.6 3.8e-06 27.2 0.6 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK37612.1 - 0.0022 18.1 0.2 0.0039 17.3 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SMN PF06003.12 PIK37612.1 - 0.079 12.2 1.1 0.093 12.0 1.1 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) ig PF00047.25 PIK37614.1 - 5.8e-06 26.4 0.0 1.8e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK37614.1 - 3.4e-05 24.3 0.0 9.7e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK37614.1 - 0.00052 20.2 0.0 0.00086 19.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK37614.1 - 0.0033 17.7 0.1 0.033 14.5 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK37614.1 - 0.12 12.5 0.0 0.42 10.7 0.0 2.1 1 1 1 2 2 2 0 Immunoglobulin I-set domain RRM_7 PF16367.5 PIK37615.1 - 2e-33 114.4 0.0 4.5e-33 113.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif CEBP_ZZ PF16366.5 PIK37615.1 - 3.3e-24 84.9 6.1 1.1e-22 80.0 6.4 2.4 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 PIK37615.1 - 1.1e-05 25.1 0.0 0.00094 19.0 0.0 2.9 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SSF PF00474.17 PIK37618.1 - 1.1e-09 37.7 0.6 1.4e-09 37.4 0.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family DAO PF01266.24 PIK37619.1 - 5.1e-14 52.6 0.0 6e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase WH1 PF00568.23 PIK37620.1 - 1.4e-32 111.9 0.4 3.4e-32 110.7 0.4 1.6 1 0 0 1 1 1 1 WH1 domain GAS PF13851.6 PIK37620.1 - 2.5e-05 23.7 30.3 0.0052 16.2 15.4 2.5 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 PIK37620.1 - 0.00027 21.0 0.9 0.00027 21.0 0.9 3.8 1 1 3 4 4 4 1 Centrosomin N-terminal motif 1 DUF4349 PF14257.6 PIK37620.1 - 0.00095 18.7 8.9 0.00095 18.7 8.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4349) BST2 PF16716.5 PIK37620.1 - 0.011 16.4 9.1 0.011 16.4 9.1 3.4 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 DUF4763 PF15960.5 PIK37620.1 - 0.011 15.1 23.0 0.14 11.5 4.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Laminin_II PF06009.12 PIK37620.1 - 0.018 15.1 7.2 0.018 15.1 7.2 2.9 2 1 0 3 3 3 0 Laminin Domain II APG6_N PF17675.1 PIK37620.1 - 0.019 15.5 14.1 0.019 15.5 14.1 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region FPP PF05911.11 PIK37620.1 - 0.023 12.9 22.7 0.06 11.5 22.1 1.8 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil TACC_C PF05010.14 PIK37620.1 - 0.041 13.7 18.2 0.072 12.9 17.5 1.8 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HAP1_N PF04849.13 PIK37620.1 - 0.054 12.7 26.5 1.1 8.4 26.5 2.2 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DUF1664 PF07889.12 PIK37620.1 - 0.056 13.5 15.8 0.048 13.7 4.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 PIK37620.1 - 0.063 12.8 33.0 0.13 11.8 10.3 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DASH_Hsk3 PF08227.11 PIK37620.1 - 0.064 13.6 1.3 0.064 13.6 1.3 4.3 3 1 2 5 5 3 0 DASH complex subunit Hsk3 like SHE3 PF17078.5 PIK37620.1 - 0.071 12.8 24.6 1.1 8.9 13.0 2.8 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 DUF3584 PF12128.8 PIK37620.1 - 0.087 10.3 20.2 0.14 9.7 20.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Lectin_N PF03954.14 PIK37620.1 - 0.1 12.3 21.0 0.039 13.7 2.1 2.7 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain ADIP PF11559.8 PIK37620.1 - 0.12 12.5 32.0 0.76 9.9 11.0 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 PIK37620.1 - 0.45 11.2 26.6 10 6.8 3.0 4.4 1 1 3 4 4 4 0 Initiation control protein YabA IFT57 PF10498.9 PIK37620.1 - 0.63 8.9 25.9 1 8.2 12.3 2.2 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Ax_dynein_light PF10211.9 PIK37620.1 - 0.67 9.9 25.5 0.15 12.0 7.2 3.4 1 1 2 3 3 3 0 Axonemal dynein light chain CC2-LZ PF16516.5 PIK37620.1 - 0.71 10.3 18.6 0.64 10.4 2.3 3.4 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PI_PP_I PF18363.1 PIK37620.1 - 0.72 10.1 7.4 36 4.6 0.7 3.7 3 1 0 3 3 3 0 Phosphoinositide phosphatase insertion domain CENP-H PF05837.12 PIK37620.1 - 1.2 9.6 26.9 0.72 10.3 6.8 2.9 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Fez1 PF06818.15 PIK37620.1 - 1.2 9.6 23.6 1.5 9.3 20.5 2.2 1 1 1 2 2 2 0 Fez1 FUSC PF04632.12 PIK37620.1 - 1.2 7.6 8.2 0.47 8.9 5.6 1.5 1 1 1 2 2 2 0 Fusaric acid resistance protein family MCC-bdg_PDZ PF10506.9 PIK37620.1 - 1.3 9.1 17.0 0.28 11.2 2.8 3.7 2 2 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Taxilin PF09728.9 PIK37620.1 - 1.3 8.1 27.5 0.31 10.2 6.4 2.3 1 1 1 2 2 2 0 Myosin-like coiled-coil protein AAA_13 PF13166.6 PIK37620.1 - 1.3 7.6 19.2 9.2 4.8 19.2 1.9 1 1 0 1 1 1 0 AAA domain ERM PF00769.19 PIK37620.1 - 1.5 8.6 26.9 0.68 9.7 6.8 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PRKG1_interact PF15898.5 PIK37620.1 - 2.2 9.3 27.5 1.8 9.5 8.2 3.5 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Spc7 PF08317.11 PIK37620.1 - 2.3 7.0 27.6 3.8 6.3 12.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4164 PF13747.6 PIK37620.1 - 2.4 8.5 15.4 6 7.2 3.4 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) CENP-F_leu_zip PF10473.9 PIK37620.1 - 3 7.9 26.4 1.4 8.9 2.8 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 PIK37620.1 - 3.6 8.0 11.2 10 6.6 0.1 4.2 2 1 1 4 4 3 0 Flagella accessory protein C (FlaC) HALZ PF02183.18 PIK37620.1 - 4 7.7 20.9 1.2 9.4 2.0 5.4 4 1 2 6 6 5 0 Homeobox associated leucine zipper HAUS-augmin3 PF14932.6 PIK37620.1 - 5.5 6.5 31.4 2.3 7.7 13.8 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF724 PF05266.14 PIK37620.1 - 5.7 6.7 22.1 1.8 8.3 7.0 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF724) SPOUT_MTase PF02590.17 PIK37620.1 - 5.9 6.8 8.3 5.8 6.9 5.3 2.2 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase Seryl_tRNA_N PF02403.22 PIK37620.1 - 6.4 7.1 17.3 2.4 8.4 6.2 2.9 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 PIK37620.1 - 6.6 6.9 34.7 3.5 7.8 10.6 2.8 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 PIK37620.1 - 7.1 6.8 29.5 2.5 8.3 7.5 2.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Nup54 PF13874.6 PIK37620.1 - 8 6.6 21.3 0.78 9.8 13.8 2.6 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 Lebercilin PF15619.6 PIK37620.1 - 9.9 5.8 28.4 10 5.7 22.2 2.8 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease RRM_1 PF00076.22 PIK37621.1 - 3.3e-17 62.1 0.1 5.1e-17 61.5 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK37621.1 - 0.001 18.7 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK37622.1 - 7.5e-15 54.5 0.0 1.2e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK37622.1 - 0.0019 18.2 0.0 0.0025 17.8 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif LRR_1 PF00560.33 PIK37623.1 - 1.8e-05 24.6 1.1 4.7 8.2 0.0 3.3 3 0 0 3 3 3 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK37623.1 - 0.0001 22.0 0.1 0.55 10.4 0.0 3.9 4 0 0 4 4 4 1 Leucine Rich repeat LRR_4 PF12799.7 PIK37623.1 - 0.0016 18.8 0.2 0.29 11.6 0.0 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) RAD51_interact PF15696.5 PIK37623.1 - 0.015 15.4 0.2 0.031 14.4 0.2 1.5 1 0 0 1 1 1 0 RAD51 interacting motif LRR_9 PF14580.6 PIK37623.1 - 0.18 11.3 0.0 0.45 10.0 0.0 1.5 1 1 0 1 1 1 0 Leucine-rich repeat RNA_pol_Rbc25 PF08292.12 PIK37624.1 - 1.7e-40 138.2 0.1 3.1e-40 137.4 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 PIK37624.1 - 5.7e-20 71.5 0.6 1.4e-19 70.2 0.1 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 BTB PF00651.31 PIK37625.1 - 5.6e-06 26.5 0.1 1.3e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK37625.1 - 0.0022 18.1 3.8 0.024 14.7 1.5 2.3 1 1 1 2 2 2 2 BTB And C-terminal Kelch STAR_dimer PF16544.5 PIK37625.1 - 0.12 11.9 1.9 0.94 9.1 0.2 2.4 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein BTB PF00651.31 PIK37626.1 - 2.6e-07 30.8 0.1 4.6e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain MutL_C PF08676.11 PIK37627.1 - 3.6e-30 104.7 0.0 8.1e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 PIK37627.1 - 1.7e-24 85.8 0.0 4.4e-24 84.4 0.0 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 PIK37627.1 - 5.1e-15 55.5 0.1 2e-14 53.6 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK37627.1 - 2.2e-06 28.2 0.0 7e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Evr1_Alr PF04777.13 PIK37628.1 - 9.1e-30 103.1 2.0 9.1e-30 103.1 2.0 1.7 2 0 0 2 2 2 1 Erv1 / Alr family zf-CHY PF05495.12 PIK37628.1 - 0.4 11.2 2.5 0.77 10.3 0.6 2.1 2 0 0 2 2 2 0 CHY zinc finger Transposase_21 PF02992.14 PIK37629.1 - 0.14 11.4 0.0 0.29 10.3 0.0 1.5 1 0 0 1 1 1 0 Transposase family tnp2 NIT PF08376.10 PIK37630.1 - 7.6e-24 85.4 0.0 9.6e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 Nitrate and nitrite sensing Mannosyl_trans PF05007.13 PIK37631.1 - 6.8e-49 167.1 9.3 6.8e-49 167.1 9.3 1.8 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 PIK37631.1 - 1.3e-13 50.8 25.5 2e-13 50.2 25.5 1.3 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 PIK37631.1 - 0.0022 17.8 5.7 0.0022 17.8 5.7 2.3 3 0 0 3 3 3 1 Glycosyltransferase family 87 Sp38 PF07354.12 PIK37631.1 - 0.011 15.1 2.1 0.024 14.0 1.5 1.7 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) Med18 PF09637.10 PIK37632.1 - 0.012 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Med18 protein GCFC PF07842.12 PIK37632.1 - 0.02 14.5 0.0 0.076 12.6 0.0 1.8 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein Phosphodiest PF01663.22 PIK37633.1 - 1.3e-11 44.7 1.6 6.9e-08 32.5 1.3 2.1 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase TetR_C_28 PF17937.1 PIK37633.1 - 0.01 16.2 0.0 0.022 15.2 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PglZ PF08665.12 PIK37633.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 PglZ domain Gal_Lectin PF02140.18 PIK37634.1 - 1.3e-08 35.1 0.6 2.3e-08 34.3 0.6 1.5 1 0 0 1 1 1 1 Galactose binding lectin domain Plasmodium_Vir PF05795.11 PIK37634.1 - 0.044 13.2 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2457 PF10446.9 PIK37634.1 - 4.5 6.3 9.8 7.4 5.6 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Gal_Lectin PF02140.18 PIK37635.1 - 1.5e-09 38.1 0.6 2.2e-09 37.6 0.6 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain Trypan_PARP PF05887.11 PIK37635.1 - 0.027 14.4 3.0 0.04 13.9 3.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3377 PF11857.8 PIK37635.1 - 0.35 10.8 0.0 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) SAPS PF04499.15 PIK37635.1 - 0.38 9.5 4.5 0.4 9.4 4.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 PIK37635.1 - 4.1 5.5 35.3 5.2 5.2 35.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK37635.1 - 4.4 6.6 34.6 5.4 6.3 34.6 1.1 1 0 0 1 1 1 0 SDA1 Fibrinogen_C PF00147.18 PIK37636.1 - 7.2e-12 45.6 0.2 9.3e-12 45.2 0.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Urm1 PF09138.11 PIK37637.1 - 1.5e-36 124.6 0.1 1.6e-36 124.5 0.1 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 PIK37637.1 - 9.2e-05 23.0 0.0 0.00011 22.8 0.0 1.1 1 0 0 1 1 1 1 ThiS family Sec1 PF00995.23 PIK37638.1 - 6.1e-62 210.6 0.2 6.9e-62 210.5 0.2 1.0 1 0 0 1 1 1 1 Sec1 family DDE_3 PF13358.6 PIK37640.1 - 1.8e-13 50.5 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 PIK37640.1 - 2.6e-06 27.6 5.5 0.00025 21.2 2.0 2.4 2 0 0 2 2 2 2 Transposase HTH_32 PF13565.6 PIK37640.1 - 0.019 15.5 1.8 0.14 12.8 0.6 2.7 2 1 1 3 3 3 0 Homeodomain-like domain Sec1 PF00995.23 PIK37641.1 - 1.4e-11 44.3 0.1 1.5e-11 44.3 0.1 1.0 1 0 0 1 1 1 1 Sec1 family DUF5641 PF18701.1 PIK37642.1 - 7.4e-35 119.0 1.5 1.1e-34 118.4 1.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) BssB_TutG PF18512.1 PIK37642.1 - 0.013 15.4 0.7 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Benzylsuccinate synthase beta subunit FMO-like PF00743.19 PIK37644.1 - 2.1e-65 221.2 0.0 2.4e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like PIG-Y PF15159.6 PIK37644.1 - 0.06 14.3 0.2 15 6.6 0.1 2.5 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y RT_RNaseH_2 PF17919.1 PIK37645.1 - 2e-37 127.2 0.0 3.9e-37 126.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37645.1 - 1.3e-35 121.8 0.0 3.4e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37645.1 - 2.3e-27 96.0 0.0 3.5e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK37646.1 - 9.8e-15 54.8 0.0 1.9e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK37646.1 - 8.8e-09 35.3 0.6 1.4e-08 34.7 0.6 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain SCAN PF02023.17 PIK37647.1 - 2.3e-13 49.7 0.0 5.7e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK37647.1 - 1.8e-06 27.7 2.0 3.6e-06 26.8 2.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK37647.1 - 0.0038 17.0 1.4 0.0069 16.2 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle DUF4407 PF14362.6 PIK37647.1 - 7.6 5.8 11.5 0.48 9.7 6.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RT_RNaseH_2 PF17919.1 PIK37648.1 - 2.9e-37 126.7 0.0 6.3e-37 125.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37648.1 - 2.5e-35 120.9 0.0 5.5e-35 119.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37648.1 - 3.6e-27 95.3 0.0 6.2e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK37649.1 - 5.3e-11 42.8 0.0 8.9e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37649.1 - 0.00023 20.9 0.2 0.0063 16.3 0.0 2.7 3 0 0 3 3 3 1 Integrase core domain UreE_N PF02814.15 PIK37649.1 - 0.25 11.0 0.1 0.25 11.0 0.1 1.8 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain Integrase_H2C2 PF17921.1 PIK37650.1 - 2.4e-19 69.2 0.1 5.5e-19 68.0 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK37650.1 - 4.1e-05 23.7 0.2 0.00033 20.8 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK37651.1 - 2.5e-37 126.9 0.7 9.9e-37 125.0 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK37651.1 - 2.4e-35 121.0 0.2 8.7e-35 119.2 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37651.1 - 6.1e-27 94.6 0.0 1.1e-26 93.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ATG11 PF10377.9 PIK37651.1 - 0.094 12.8 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Autophagy-related protein 11 CREPT PF16566.5 PIK37651.1 - 7.7 6.7 7.2 4.5 7.4 0.4 3.1 4 0 0 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour SGS PF05002.15 PIK37652.1 - 1.7e-05 24.8 20.7 5 7.3 0.1 8.4 1 1 8 9 9 9 4 SGS domain DUF5541 PF17695.1 PIK37652.1 - 0.0036 17.7 20.1 49 4.4 0.0 8.2 1 1 8 9 9 9 1 Family of unknown function (DUF5541) DDE_Tnp_1_2 PF13586.6 PIK37652.1 - 0.091 13.1 6.7 1.4e+02 2.9 0.0 5.2 1 1 8 9 9 9 0 Transposase DDE domain RVT_1 PF00078.27 PIK37653.1 - 1.7e-36 125.9 0.8 2.7e-29 102.3 0.1 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK37655.1 - 2.2e-26 93.0 0.2 3.5e-26 92.3 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IF2_N PF04760.15 PIK37655.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Retrotran_gag_2 PF14223.6 PIK37656.1 - 1.1e-17 64.0 0.0 2e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type NACHT PF05729.12 PIK37657.1 - 7.9e-16 58.4 0.0 1.8e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK37657.1 - 6.5e-11 42.4 0.7 0.00036 20.7 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK37657.1 - 4.6e-08 33.1 2.6 0.1 12.8 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.6 PIK37657.1 - 5.2e-07 30.2 2.0 0.16 12.6 0.0 4.8 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK37657.1 - 2.7e-05 24.1 0.5 0.2 11.8 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK37657.1 - 0.00057 20.2 2.9 1.7 9.0 0.0 4.6 4 1 0 4 4 4 1 Immunoglobulin domain AAA_25 PF13481.6 PIK37657.1 - 0.0035 16.9 0.0 0.016 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK37657.1 - 0.0049 17.2 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain TMEM154 PF15102.6 PIK37657.1 - 0.0098 15.8 0.3 0.024 14.5 0.3 1.6 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 PIK37657.1 - 0.045 14.6 0.4 0.17 12.8 0.1 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 PIK37657.1 - 0.23 11.3 7.3 0.035 14.0 3.0 1.7 2 0 0 2 2 2 0 Rifin Adeno_E3_CR2 PF02439.15 PIK37657.1 - 0.29 10.9 3.3 0.62 9.9 3.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Hs1pro-1_N PF07231.12 PIK37658.1 - 0.027 14.2 0.0 0.05 13.3 0.0 1.5 2 0 0 2 2 2 0 Hs1pro-1 N-terminus RNA_pol_Rpb5_N PF03871.14 PIK37659.1 - 3.9e-34 117.1 0.1 7.1e-34 116.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.19 PIK37659.1 - 9.7e-14 51.0 3.9 3.6e-06 26.7 0.0 2.9 3 0 0 3 3 3 2 RNA polymerase Rpb5, C-terminal domain SPX PF03105.19 PIK37660.1 - 0.026 14.5 1.2 0.037 14.0 1.2 1.2 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 PIK37660.1 - 0.18 10.3 2.4 0.28 9.7 2.4 1.2 1 0 0 1 1 1 0 Macoilin family GST_C_3 PF14497.6 PIK37661.1 - 1.5e-18 66.8 0.0 2.2e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK37661.1 - 3.9e-09 36.7 0.0 1.4e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK37661.1 - 0.00014 22.0 0.0 0.00025 21.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK37661.1 - 0.0014 19.0 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK37661.1 - 0.0068 16.7 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK37661.1 - 0.0069 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_transf_10 PF00852.19 PIK37662.1 - 2.4e-46 157.6 0.1 3.6e-46 157.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK37662.1 - 3.8e-05 24.1 0.7 9.2e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Mut7-C PF01927.16 PIK37662.1 - 0.041 14.0 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 Mut7-C RNAse domain Peptidase_C54 PF03416.19 PIK37663.1 - 8e-107 356.8 0.0 5.5e-57 193.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase family C54 fn3 PF00041.21 PIK37664.1 - 4.4e-14 52.6 4.5 1.3e-07 31.9 0.3 3.9 3 0 0 3 3 3 3 Fibronectin type III domain zf-RING_UBOX PF13445.6 PIK37665.1 - 2.8e-08 33.7 7.3 2.8e-08 33.7 7.3 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK37665.1 - 3.3e-08 33.3 10.5 3.3e-08 33.3 10.5 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK37665.1 - 1.3e-06 28.6 9.6 1.3e-06 28.6 9.6 3.3 3 0 0 3 3 2 1 Ring finger domain zf-B_box PF00643.24 PIK37665.1 - 3.2e-06 27.2 22.4 4.6e-05 23.5 7.4 3.9 4 0 0 4 4 4 2 B-box zinc finger zf-C3HC4_2 PF13923.6 PIK37665.1 - 8.3e-06 25.6 10.6 8.3e-06 25.6 10.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK37665.1 - 2.6e-05 24.0 11.5 2.6e-05 24.0 11.5 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK37665.1 - 0.00032 20.8 10.4 0.00032 20.8 10.4 3.2 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 PIK37665.1 - 0.0035 17.0 4.2 0.012 15.4 4.2 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 PIK37665.1 - 0.0086 16.0 8.7 0.0086 16.0 8.7 3.5 3 0 0 3 3 3 1 zinc-RING finger domain Exonuc_VII_L PF02601.15 PIK37665.1 - 0.92 9.0 8.5 1.7 8.2 8.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 PIK37665.1 - 0.93 8.8 11.3 1.5 8.1 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COQ7 PF03232.13 PIK37665.1 - 1.9 8.2 5.8 16 5.2 5.7 2.3 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 LMBR1 PF04791.16 PIK37665.1 - 2.7 6.8 8.0 4.1 6.2 8.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Fibrinogen_C PF00147.18 PIK37666.1 - 3.1e-45 154.7 10.9 4.5e-45 154.1 10.9 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK37666.1 - 0.00025 21.2 5.3 0.00025 21.2 5.3 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK37666.1 - 0.00042 20.5 5.7 0.00042 20.5 5.7 3.2 4 0 0 4 4 4 1 EGF domain TILa PF12714.7 PIK37666.1 - 4.5 7.3 19.1 0.1 12.6 1.8 2.8 2 1 1 3 3 3 0 TILa domain C8 PF08742.11 PIK37667.1 - 2.9e-14 53.3 0.7 2.9e-14 53.3 0.7 2.4 2 1 0 2 2 2 1 C8 domain VWD PF00094.25 PIK37667.1 - 0.0045 17.3 2.6 0.0087 16.3 2.6 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF3895 PF13034.6 PIK37667.1 - 0.041 13.9 0.0 0.095 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3895) VWD PF00094.25 PIK37668.1 - 4.9e-40 137.4 0.3 3.7e-27 95.5 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 PIK37668.1 - 3.5e-15 56.2 2.9 3.5e-15 56.2 2.9 3.6 3 1 0 3 3 3 1 C8 domain TILa PF12714.7 PIK37668.1 - 1.8e-12 47.0 23.3 3.4e-08 33.3 5.9 5.3 4 1 0 5 5 5 2 TILa domain EGF_3 PF12947.7 PIK37668.1 - 3.8e-05 23.8 23.1 0.00057 20.0 10.8 5.6 5 0 0 5 5 5 2 EGF domain Ig_4 PF16680.5 PIK37669.1 - 0.00024 21.3 0.0 0.0042 17.3 0.0 2.4 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain hEGF PF12661.7 PIK37669.1 - 0.0003 21.3 8.4 0.0003 21.3 8.4 3.4 4 1 0 4 4 3 1 Human growth factor-like EGF EGF PF00008.27 PIK37669.1 - 0.0013 19.0 11.0 0.0013 19.0 11.0 2.3 3 0 0 3 3 3 1 EGF-like domain Ig_5 PF16681.5 PIK37669.1 - 0.0027 18.1 0.0 0.017 15.5 0.0 2.2 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.6 PIK37669.1 - 0.0039 17.7 0.7 0.0095 16.5 0.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK37669.1 - 0.0052 17.1 0.5 0.017 15.5 0.2 1.9 1 1 1 2 2 2 1 Immunoglobulin domain EGF_2 PF07974.13 PIK37669.1 - 0.0062 16.9 11.0 0.0062 16.9 11.0 2.4 2 1 0 2 2 2 1 EGF-like domain DSL PF01414.19 PIK37669.1 - 0.028 14.7 8.4 0.028 14.7 8.4 2.6 3 0 0 3 3 3 0 Delta serrate ligand I-set PF07679.16 PIK37669.1 - 0.083 13.0 0.3 0.27 11.3 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 PIK37669.1 - 0.093 12.9 0.3 0.33 11.2 0.3 2.0 1 1 0 1 1 1 0 Immunoglobulin V-set domain PfaD_N PF18328.1 PIK37669.1 - 0.15 12.0 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain Aldo_ket_red PF00248.21 PIK37670.1 - 1.5e-09 37.5 0.0 1.5e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SWIB PF02201.18 PIK37671.1 - 2.8e-23 81.6 0.1 6.4e-23 80.4 0.1 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain Ssu72 PF04722.13 PIK37671.1 - 0.066 12.8 0.7 0.11 12.1 0.7 1.3 1 0 0 1 1 1 0 Ssu72-like protein Dimer_Tnp_hAT PF05699.14 PIK37672.1 - 4.7e-06 26.3 0.0 1.5e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Amidohydro_2 PF04909.14 PIK37673.1 - 1.1e-67 228.9 0.1 1.2e-67 228.8 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase Lectin_C PF00059.21 PIK37674.1 - 2.4e-05 25.0 0.0 6.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain Ytp1 PF10355.9 PIK37674.1 - 0.016 14.5 0.1 3.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (Ytp1) Gag_p6 PF08705.11 PIK37674.1 - 0.03 14.6 1.8 5.3 7.4 0.2 2.7 2 0 0 2 2 2 0 Gag protein p6 Lectin_C PF00059.21 PIK37675.1 - 0.00013 22.6 0.0 0.00029 21.5 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Glyco_transf_10 PF00852.19 PIK37676.1 - 4.1e-50 169.9 1.0 7.3e-50 169.1 1.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK37676.1 - 0.0071 16.8 0.6 0.04 14.4 0.0 2.2 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Surp PF01805.20 PIK37676.1 - 0.12 12.4 0.4 0.3 11.1 0.4 1.7 1 0 0 1 1 1 0 Surp module Putative_PNPOx PF01243.20 PIK37677.1 - 9.5e-27 93.0 0.0 1.5e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 PIK37677.1 - 5.9e-19 67.9 0.9 1.1e-18 67.0 0.9 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 PIK37677.1 - 8.8e-06 26.3 0.0 1.5e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Methyltransf_16 PF10294.9 PIK37678.1 - 5.1e-15 55.6 0.0 8.8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 PIK37678.1 - 7.7e-08 32.3 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37678.1 - 3.6e-07 30.1 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37678.1 - 5.5e-07 30.2 0.0 1e-06 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK37678.1 - 2.9e-05 24.7 0.0 0.00014 22.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK37678.1 - 9.2e-05 23.0 0.0 0.00025 21.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 PIK37678.1 - 0.005 16.3 0.0 0.018 14.5 0.0 1.8 1 1 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 PIK37678.1 - 0.013 15.1 0.0 0.029 13.9 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 PIK37678.1 - 0.064 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Phage_Integr_2 PF13009.6 PIK37678.1 - 0.077 12.1 0.0 0.093 11.8 0.0 1.1 1 0 0 1 1 1 0 Putative phage integrase Ubie_methyltran PF01209.18 PIK37678.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SAP PF02037.27 PIK37679.1 - 9.1e-14 50.8 2.3 2.4e-13 49.5 2.3 1.8 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 PIK37679.1 - 1.7e-05 24.5 18.7 0.037 13.8 0.9 4.6 4 1 0 4 4 4 3 Tho1/MOS11 C-terminal domain Merozoite_SPAM PF07133.11 PIK37679.1 - 0.17 11.9 25.9 0.27 11.2 25.9 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 PIK37679.1 - 5.1 5.3 12.1 5.6 5.1 12.1 1.2 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 PIK37680.1 - 5.3e-13 48.6 20.0 9.8e-10 37.9 15.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily GTP1_OBG PF01018.22 PIK37681.1 - 7.5e-23 80.8 5.7 3.5e-22 78.7 5.7 2.0 1 1 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 PIK37681.1 - 9.8e-12 45.0 0.0 1.8e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK37681.1 - 7.8e-08 32.0 0.0 4.5e-05 23.0 0.0 2.2 1 1 1 2 2 2 2 Ferrous iron transport protein B MeaB PF03308.16 PIK37681.1 - 3.3e-06 26.3 0.3 0.0076 15.3 0.0 2.2 1 1 1 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 PIK37681.1 - 0.0016 18.9 0.0 0.003 18.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter MMR_HSR1_Xtn PF16897.5 PIK37681.1 - 0.0051 16.8 0.0 0.0079 16.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain CbiA PF01656.23 PIK37681.1 - 0.0066 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Arf PF00025.21 PIK37681.1 - 0.017 14.5 0.1 2.4 7.6 0.0 2.2 1 1 1 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK37681.1 - 0.042 13.4 0.0 10 5.6 0.0 2.2 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 PIK37681.1 - 0.048 13.4 0.0 0.68 9.7 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MnmE_helical PF12631.7 PIK37681.1 - 0.081 13.1 0.0 0.081 13.1 0.0 1.2 1 0 0 1 1 1 0 MnmE helical domain RsgA_GTPase PF03193.16 PIK37681.1 - 0.095 12.6 0.1 3.9 7.4 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 PIK37681.1 - 0.11 12.2 0.0 7.7 6.2 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ank_2 PF12796.7 PIK37682.1 - 1.8e-07 31.7 0.0 7.9e-05 23.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK37682.1 - 9.9e-05 22.5 0.4 0.04 14.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat TRP_2 PF08344.11 PIK37682.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_4 PF13637.6 PIK37682.1 - 0.00062 20.3 0.0 0.027 15.1 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK37682.1 - 0.0021 18.3 0.1 0.087 13.2 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK37682.1 - 0.015 15.8 0.1 0.11 13.0 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Ion_trans PF00520.31 PIK37683.1 - 5.4e-15 55.3 19.3 8.2e-15 54.7 19.3 1.3 1 0 0 1 1 1 1 Ion transport protein DUF21 PF01595.20 PIK37683.1 - 0.075 12.7 5.3 0.18 11.5 5.3 1.7 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain AAA PF00004.29 PIK37684.1 - 2.5e-43 147.7 0.0 4.7e-43 146.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 PIK37684.1 - 1.5e-07 31.7 0.0 2.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 PIK37684.1 - 1.9e-06 28.4 0.1 2.8e-05 24.6 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK37684.1 - 3.2e-06 27.2 1.1 7.6e-06 26.0 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK37684.1 - 2e-05 24.9 0.4 0.0089 16.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 PIK37684.1 - 4.3e-05 23.3 0.0 8.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Prot_ATP_ID_OB PF16450.5 PIK37684.1 - 0.00024 21.0 0.0 0.00055 19.8 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_33 PF13671.6 PIK37684.1 - 0.0013 18.9 0.0 0.0024 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK37684.1 - 0.0019 18.7 0.1 0.01 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 PIK37684.1 - 0.0021 17.3 0.2 0.0043 16.3 0.0 1.6 2 0 0 2 2 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 PIK37684.1 - 0.0023 17.7 0.0 0.0045 16.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase PF06745.13 PIK37684.1 - 0.0052 16.1 0.0 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 KaiC PhoH PF02562.16 PIK37684.1 - 0.0063 16.0 0.0 0.1 12.0 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 PIK37684.1 - 0.0087 15.5 0.1 0.021 14.2 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 PIK37684.1 - 0.01 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK37684.1 - 0.014 15.1 0.1 0.081 12.6 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 PIK37684.1 - 0.014 15.6 0.4 0.026 14.8 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 PIK37684.1 - 0.018 14.7 0.1 0.05 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 PIK37684.1 - 0.023 15.1 0.1 0.47 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK37684.1 - 0.023 14.2 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 PIK37684.1 - 0.027 13.6 0.0 0.083 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 PIK37684.1 - 0.03 13.5 0.0 0.48 9.6 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain SlyX PF04102.12 PIK37684.1 - 0.032 14.8 2.1 0.12 13.0 2.1 2.0 1 0 0 1 1 1 0 SlyX TsaE PF02367.17 PIK37684.1 - 0.038 14.0 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 PIK37684.1 - 0.04 14.0 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK37684.1 - 0.04 14.3 0.0 0.074 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 PIK37684.1 - 0.042 13.6 0.4 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 PIK37684.1 - 0.051 12.7 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 PIK37684.1 - 0.053 13.1 0.4 0.14 11.7 0.0 1.9 3 0 0 3 3 1 0 AAA domain ABC_tran PF00005.27 PIK37684.1 - 0.055 14.0 0.3 0.73 10.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 PIK37684.1 - 0.067 13.5 1.0 0.34 11.3 0.1 2.4 3 1 0 3 3 2 0 AAA domain DUF4618 PF15397.6 PIK37684.1 - 0.092 12.2 3.5 0.22 10.9 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Zeta_toxin PF06414.12 PIK37684.1 - 0.093 12.0 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 PIK37684.1 - 0.11 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Spc24 PF08286.11 PIK37684.1 - 0.11 12.8 0.3 0.25 11.6 0.3 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 RILP PF11461.8 PIK37684.1 - 0.13 12.5 7.6 0.75 10.1 7.6 2.1 1 1 0 1 1 1 0 Rab interacting lysosomal protein Viral_P18 PF04521.13 PIK37684.1 - 0.17 11.7 0.4 0.31 10.8 0.4 1.3 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein FlxA PF14282.6 PIK37684.1 - 0.27 11.2 1.0 1.1 9.3 0.6 2.0 2 0 0 2 2 2 0 FlxA-like protein DUF743 PF05332.11 PIK37684.1 - 0.72 9.9 2.7 1.7 8.7 0.2 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF743) V-SNARE PF05008.15 PIK37684.1 - 5.3 7.5 8.3 1.1 9.7 4.1 2.0 3 0 0 3 3 1 0 Vesicle transport v-SNARE protein N-terminus Lipase_GDSL PF00657.22 PIK37685.1 - 0.021 14.8 0.0 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Lipase_GDSL PF00657.22 PIK37686.1 - 3.4e-18 66.4 0.0 5.1e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK37686.1 - 7.3e-08 33.0 0.0 2.5e-07 31.2 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Radical_SAM PF04055.21 PIK37686.1 - 0.092 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Radical SAM superfamily Lipase_GDSL PF00657.22 PIK37687.1 - 2.8e-20 73.2 0.0 3.8e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK37687.1 - 8.3e-07 29.6 0.2 2.1e-06 28.2 0.2 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK37688.1 - 2.8e-12 47.0 0.0 7.6e-12 45.6 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK37688.1 - 8.8e-06 26.2 0.0 1.4e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family 7tm_1 PF00001.21 PIK37689.1 - 5.2e-19 68.6 13.9 6.2e-19 68.3 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-C2H2 PF00096.26 PIK37690.1 - 3.7e-20 71.2 70.4 0.00031 21.0 2.0 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK37690.1 - 9.8e-16 57.1 64.5 0.035 15.0 1.7 9.5 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK37690.1 - 1.2e-13 50.8 73.9 1.9e-06 28.0 0.2 9.5 9 1 0 9 9 9 6 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK37690.1 - 1.9e-06 27.7 45.6 0.46 10.5 0.7 8.6 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK37690.1 - 0.001 19.3 33.1 0.026 14.8 5.2 4.4 1 1 3 4 4 4 2 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 PIK37690.1 - 0.011 15.8 1.2 0.011 15.8 1.2 6.0 5 1 0 5 5 5 0 Zinc ribbon domain PRP21_like_P PF12230.8 PIK37690.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.0 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein zf-FLZ PF04570.14 PIK37690.1 - 0.64 9.5 8.3 0.24 10.9 0.2 3.8 4 0 0 4 4 4 0 zinc-finger of the FCS-type, C2-C2 Zn-C2H2_12 PF18112.1 PIK37690.1 - 1.1 9.8 12.3 10 6.7 0.1 5.3 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 PIK37690.1 - 1.5 9.2 44.6 0.13 12.6 0.7 6.0 4 2 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 PIK37690.1 - 5.3 7.9 34.4 52 4.7 5.1 5.3 1 1 3 4 4 3 0 zinc-ribbon family zf-CSL PF05207.13 PIK37690.1 - 6.2 6.6 21.6 2 8.2 1.1 5.1 3 1 1 4 4 4 0 CSL zinc finger DUF5104 PF17117.5 PIK37691.1 - 0.09 13.2 5.1 5.2 7.5 0.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5104) DUF1053 PF06327.14 PIK37691.1 - 9.1 6.9 8.7 0.77 10.3 0.3 2.8 1 1 2 3 3 3 0 Domain of Unknown Function (DUF1053) RVT_1 PF00078.27 PIK37692.1 - 1.3e-29 103.3 0.1 2.7e-29 102.3 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK37692.1 - 6.9e-25 87.6 0.1 1.7e-24 86.3 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK37692.1 - 1.9e-19 69.5 0.7 1.9e-19 69.5 0.7 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK37692.1 - 3.3e-06 26.8 1.8 1.6e-05 24.6 0.7 2.5 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK37692.1 - 0.075 13.1 5.6 0.26 11.4 5.6 2.0 1 0 0 1 1 1 0 Zinc knuckle zf-H2C2 PF09337.10 PIK37692.1 - 0.086 13.1 0.7 0.2 11.9 0.7 1.7 1 0 0 1 1 1 0 H2C2 zinc finger zf-CCHC_5 PF14787.6 PIK37692.1 - 3.7 7.4 6.2 0.29 10.9 0.7 2.1 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RT_RNaseH_2 PF17919.1 PIK37693.1 - 4.9e-27 93.9 0.0 1.4e-26 92.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK37693.1 - 1.9e-25 89.4 0.1 4e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK37693.1 - 2.1e-24 85.8 0.0 5.5e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK37693.1 - 4.7e-10 39.4 0.1 7.4e-09 35.4 0.1 2.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK37693.1 - 3.3e-07 30.0 1.6 4.7e-06 26.3 0.7 2.7 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK37694.1 - 0.0059 16.6 5.0 0.0099 15.9 5.0 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK37694.1 - 0.026 14.8 0.0 0.072 13.4 0.0 1.8 1 0 0 1 1 1 0 Retrotransposon gag protein SQAPI PF16845.5 PIK37694.1 - 0.053 13.9 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor zf-CCHC_5 PF14787.6 PIK37694.1 - 0.073 12.8 1.0 0.15 11.8 1.0 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger SlyX PF04102.12 PIK37694.1 - 2.7 8.7 5.0 15 6.3 0.1 3.0 3 0 0 3 3 3 0 SlyX Dymeclin PF09742.9 PIK37695.1 - 2.7e-128 429.1 14.1 1.2e-113 380.8 11.8 2.0 1 1 1 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 PIK37695.1 - 6.2e-09 34.6 17.8 0.00031 19.0 13.7 3.7 2 1 1 3 3 3 3 High-temperature-induced dauer-formation protein HEAT_2 PF13646.6 PIK37696.1 - 0.00034 20.9 0.1 0.69 10.3 0.2 2.5 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 PIK37696.1 - 0.00042 20.4 0.6 0.00091 19.3 0.6 1.5 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.8 PIK37696.1 - 0.02 15.5 0.1 0.31 11.7 0.0 2.8 1 1 1 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation V-ATPase_H_N PF03224.14 PIK37696.1 - 0.067 12.5 0.1 0.44 9.8 0.0 1.9 1 1 1 2 2 2 0 V-ATPase subunit H RTP1_C1 PF10363.9 PIK37696.1 - 0.074 13.2 0.2 0.71 10.1 0.2 2.2 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Anti-adapt_IraP PF10796.9 PIK37697.1 - 0.018 15.6 0.1 0.055 14.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein CLASP_N PF12348.8 PIK37698.1 - 8.2e-51 172.7 6.1 6.2e-36 124.1 1.9 2.1 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 PIK37698.1 - 1.5e-14 52.8 4.2 2.1e-05 24.4 0.0 6.6 8 0 0 8 8 8 3 HEAT repeat Cnd1 PF12717.7 PIK37698.1 - 1.9e-08 34.5 0.8 0.0064 16.6 0.0 4.1 2 2 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK37698.1 - 3.4e-08 33.8 0.0 0.011 16.1 0.0 5.4 2 2 2 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 PIK37698.1 - 3.1e-05 24.5 0.0 0.35 11.5 0.0 4.4 3 1 2 5 5 5 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 PIK37698.1 - 0.00012 20.8 1.1 0.77 8.2 0.0 3.5 2 2 1 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 PIK37698.1 - 0.00055 20.4 0.0 0.075 13.6 0.0 3.3 2 0 0 2 2 2 1 HEAT-like repeat Tti2 PF10521.9 PIK37698.1 - 0.043 13.4 0.3 4.2 6.8 0.0 3.4 2 2 1 3 3 3 0 Tti2 family MMS19_N PF14500.6 PIK37698.1 - 0.071 12.7 0.3 2.7 7.5 0.0 2.9 3 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Cohesin_HEAT PF12765.7 PIK37698.1 - 0.077 13.3 0.0 4.4 7.7 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion SLED PF12140.8 PIK37698.1 - 0.097 13.2 0.2 4.1 8.0 0.0 2.7 2 0 0 2 2 2 0 SLED domain IQ PF00612.27 PIK37699.1 - 8.3e-15 53.1 23.3 3.5e-05 23.2 1.8 5.7 6 0 0 6 6 6 3 IQ calmodulin-binding motif Dfp1_Him1_M PF08630.10 PIK37699.1 - 3.5 7.9 10.6 3.9 7.7 0.1 3.4 3 0 0 3 3 3 0 Dfp1/Him1, central region rve PF00665.26 PIK37700.1 - 7.8e-18 64.8 0.0 2.5e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK37700.1 - 5.1e-16 58.5 0.0 2.9e-15 56.1 0.0 2.3 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK37700.1 - 4.1e-15 55.6 0.3 7.3e-15 54.8 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK37700.1 - 2.6e-12 46.8 0.0 5.7e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK37700.1 - 4.1e-09 37.0 0.0 8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK37700.1 - 5.3e-09 36.5 0.0 1e-08 35.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RT_RNaseH PF17917.1 PIK37700.1 - 3.9e-08 33.5 0.0 1.3e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVP PF00077.20 PIK37700.1 - 0.00051 20.3 0.0 0.0016 18.7 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK37700.1 - 0.0063 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease NACHT PF05729.12 PIK37701.1 - 1.8e-14 54.0 0.0 3.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK37701.1 - 0.00051 19.7 0.0 0.0009 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 PIK37701.1 - 0.16 11.7 0.0 3.9 7.2 0.0 2.4 2 1 0 2 2 2 0 DEAD/DEAH box helicase DNA_pol_lambd_f PF10391.9 PIK37702.1 - 0.012 15.4 0.0 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Preseq_ALAS PF09029.10 PIK37702.1 - 0.018 15.5 0.2 12 6.4 0.0 2.7 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence DUF5625 PF18539.1 PIK37702.1 - 0.16 12.3 0.2 34 4.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5625) SNAD4 PF18750.1 PIK37704.1 - 0.011 15.8 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 dCMP_cyt_deam_1 PF00383.23 PIK37704.1 - 0.061 13.2 1.4 0.29 11.0 0.0 2.5 3 0 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region AID PF18767.1 PIK37704.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Activation induced deaminase zf-RAG1 PF10426.9 PIK37704.1 - 0.29 11.3 3.4 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Recombination-activating protein 1 zinc-finger domain Peptidase_C14 PF00656.22 PIK37705.1 - 1.3e-25 90.8 0.2 2.1e-25 90.1 0.2 1.3 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 PIK37706.1 - 6.9e-20 71.1 6.8 1e-11 45.0 1.0 2.3 2 0 0 2 2 2 2 Death effector domain SH3BP5 PF05276.14 PIK37707.1 - 0.0005 19.9 3.3 0.00077 19.3 3.3 1.2 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) Band_7 PF01145.25 PIK37707.1 - 0.00056 20.0 0.1 0.004 17.2 0.0 2.2 1 1 2 3 3 3 1 SPFH domain / Band 7 family AAA PF00004.29 PIK37708.1 - 2.5e-94 312.7 0.0 1.1e-45 155.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 PIK37708.1 - 1.1e-20 73.6 2.2 3.5e-20 72.0 2.2 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 PIK37708.1 - 2.7e-14 53.2 0.0 1.4e-05 24.9 0.0 3.1 2 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK37708.1 - 4.2e-13 50.0 0.3 0.00015 22.1 0.1 4.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 PIK37708.1 - 1.3e-11 44.1 1.5 3e-11 42.9 0.1 2.4 3 0 0 3 3 2 1 AAA+ lid domain AAA_2 PF07724.14 PIK37708.1 - 4.4e-11 43.2 0.0 1.1e-05 25.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 PIK37708.1 - 4.7e-11 42.3 0.0 1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 PIK37708.1 - 2e-10 41.0 0.0 0.0001 22.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 PIK37708.1 - 6.8e-10 39.1 0.1 0.0002 21.4 0.0 3.3 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK37708.1 - 2.9e-09 37.3 0.3 0.044 14.0 0.0 3.7 2 2 2 4 4 3 2 AAA domain TIP49 PF06068.13 PIK37708.1 - 1.4e-08 34.4 0.2 0.0072 15.6 0.0 3.4 3 0 0 3 3 3 2 TIP49 P-loop domain Vps4_C PF09336.10 PIK37708.1 - 2.7e-08 33.7 2.0 1.3e-06 28.3 0.3 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_18 PF13238.6 PIK37708.1 - 4.8e-08 33.6 0.0 0.014 16.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 PIK37708.1 - 1.5e-07 31.7 0.0 0.0052 17.1 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 PIK37708.1 - 4.8e-07 29.9 0.0 0.028 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 PIK37708.1 - 7.6e-07 28.7 0.1 0.017 14.5 0.0 2.6 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 PIK37708.1 - 8.8e-07 28.8 0.0 0.056 13.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 PIK37708.1 - 1.2e-06 29.1 0.0 0.0049 17.4 0.0 3.4 2 1 0 2 2 2 1 ABC transporter AAA_25 PF13481.6 PIK37708.1 - 3.8e-06 26.6 0.1 0.79 9.3 0.0 3.6 2 1 0 3 3 3 1 AAA domain Bac_DnaA PF00308.18 PIK37708.1 - 4.8e-06 26.6 0.0 0.024 14.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein ATPase_2 PF01637.18 PIK37708.1 - 6.2e-06 26.3 0.3 0.24 11.3 0.0 3.5 3 1 0 3 3 2 2 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 PIK37708.1 - 3.2e-05 23.2 0.1 0.036 13.1 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 PIK37708.1 - 3.2e-05 23.5 0.0 0.1 12.1 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 PIK37708.1 - 3.3e-05 23.7 0.0 0.078 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 PIK37708.1 - 5.8e-05 23.4 0.0 0.17 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 PIK37708.1 - 7e-05 23.3 0.0 0.76 10.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 PIK37708.1 - 7.3e-05 22.8 0.0 0.28 11.2 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 PIK37708.1 - 0.00013 21.2 0.0 0.23 10.6 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.26 PIK37708.1 - 0.00014 21.6 0.0 0.9 9.2 0.0 3.0 2 2 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 PIK37708.1 - 0.00018 20.9 0.2 2.4 7.5 0.0 3.5 3 0 0 3 3 3 1 KaiC NACHT PF05729.12 PIK37708.1 - 0.00018 21.4 0.2 0.29 11.0 0.0 3.2 3 1 1 4 4 3 1 NACHT domain Viral_helicase1 PF01443.18 PIK37708.1 - 0.00022 21.0 0.0 0.003 17.3 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 PIK37708.1 - 0.00029 20.7 0.0 0.96 9.3 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 PIK37708.1 - 0.00041 19.6 0.0 0.15 11.2 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 PIK37708.1 - 0.00083 18.7 0.0 0.5 9.6 0.0 2.8 3 0 0 3 3 3 1 Zeta toxin Sigma54_activ_2 PF14532.6 PIK37708.1 - 0.003 17.7 0.0 2.8 8.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ResIII PF04851.15 PIK37708.1 - 0.0031 17.5 0.0 0.42 10.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rad17 PF03215.15 PIK37708.1 - 0.0054 16.7 0.0 0.95 9.4 0.0 2.6 2 1 0 2 2 2 1 Rad17 P-loop domain KAP_NTPase PF07693.14 PIK37708.1 - 0.0071 15.6 0.1 0.34 10.1 0.0 3.0 2 2 1 4 4 4 1 KAP family P-loop domain NTPase_1 PF03266.15 PIK37708.1 - 0.0097 15.8 0.2 5.4 6.9 0.0 3.2 3 0 0 3 3 3 0 NTPase PhoH PF02562.16 PIK37708.1 - 0.012 15.0 0.2 1.7 8.1 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 PIK37708.1 - 0.018 14.3 0.0 5.1 6.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 PIK37708.1 - 0.021 15.2 0.6 14 6.0 0.0 3.1 3 0 0 3 3 2 0 AAA domain SKI PF01202.22 PIK37708.1 - 0.049 13.8 0.0 8.9 6.4 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase AAA_11 PF13086.6 PIK37708.1 - 0.053 13.3 0.0 5.9 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 PIK37708.1 - 0.19 11.4 0.2 24 4.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain Band_7 PF01145.25 PIK37709.1 - 0.00019 21.5 0.0 0.00052 20.1 0.0 1.8 1 1 0 1 1 1 1 SPFH domain / Band 7 family DeoRC PF00455.22 PIK37709.1 - 0.089 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 DeoR C terminal sensor domain EGF_2 PF07974.13 PIK37710.1 - 2e-26 92.0 189.5 0.00037 20.8 10.5 12.1 11 0 0 11 11 11 10 EGF-like domain VWD PF00094.25 PIK37710.1 - 1.2e-15 58.2 0.5 1.4e-14 54.7 0.1 2.8 3 0 0 3 3 3 1 von Willebrand factor type D domain hEGF PF12661.7 PIK37710.1 - 3e-05 24.5 163.4 0.019 15.6 7.9 13.3 14 0 0 14 14 14 9 Human growth factor-like EGF EGF PF00008.27 PIK37710.1 - 0.00013 22.1 3.7 0.00013 22.1 3.7 14.1 15 0 0 15 15 15 9 EGF-like domain Transposase_21 PF02992.14 PIK37711.1 - 0.00013 21.3 0.0 0.00027 20.3 0.0 1.5 1 0 0 1 1 1 1 Transposase family tnp2 zf-C2H2_aberr PF17017.5 PIK37711.1 - 0.064 13.4 2.0 0.21 11.7 0.3 2.5 2 1 0 2 2 2 0 Aberrant zinc-finger Tannase PF07519.11 PIK37712.1 - 0.0019 17.2 2.7 0.002 17.1 2.7 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Microvir_H PF04687.12 PIK37712.1 - 1.6 8.1 9.6 1.8 7.8 9.6 1.1 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Band_7 PF01145.25 PIK37714.1 - 3.7e-09 36.8 0.0 5.5e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family GP68 PF17469.2 PIK37715.1 - 0.031 14.7 1.1 0.056 13.8 0.7 1.6 1 1 0 1 1 1 0 Phage protein Gp68 Band_7 PF01145.25 PIK37715.1 - 0.088 12.8 0.3 0.12 12.4 0.3 1.2 1 0 0 1 1 1 0 SPFH domain / Band 7 family CALM_bind PF16025.5 PIK37715.1 - 0.12 12.9 1.6 0.18 12.3 1.6 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Gal_Lectin PF02140.18 PIK37716.1 - 2.1e-43 146.6 16.9 2.4e-24 85.6 3.1 3.4 4 0 0 4 4 4 3 Galactose binding lectin domain DUF3395 PF11875.8 PIK37716.1 - 0.0089 15.9 0.1 4.8 7.1 0.0 2.7 3 1 0 3 3 3 2 Domain of unknown function (DUF3395) Ras PF00071.22 PIK37717.1 - 3.5e-15 56.0 0.0 5.9e-09 35.7 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK37717.1 - 0.0033 17.6 0.0 0.0047 17.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK37718.1 - 1.3e-12 47.7 0.0 1.4e-12 47.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Ntox3 PF15536.6 PIK37719.1 - 0.086 12.9 0.1 0.43 10.6 0.0 1.8 1 1 1 2 2 2 0 Bacterial toxin 3 Ras PF00071.22 PIK37720.1 - 2.7e-59 199.4 1.9 3.1e-59 199.2 1.9 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK37720.1 - 4.6e-29 101.1 0.8 4.6e-29 101.1 0.8 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK37720.1 - 3.4e-13 49.4 0.7 4.4e-13 49.1 0.7 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK37720.1 - 1.9e-05 24.3 0.6 5.7e-05 22.7 0.6 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK37720.1 - 9.2e-05 21.9 0.5 0.00012 21.6 0.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK37720.1 - 0.0017 18.4 0.1 0.0033 17.5 0.1 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 PIK37720.1 - 0.0076 15.6 0.1 0.016 14.5 0.0 1.5 2 0 0 2 2 2 1 Septin DUF3963 PF13124.6 PIK37720.1 - 0.016 15.1 0.3 0.034 14.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Pkinase PF00069.25 PIK37722.1 - 7.7e-65 218.9 0.1 1.1e-64 218.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37722.1 - 1.6e-39 135.7 0.0 2.6e-39 135.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK37722.1 - 3.8e-08 33.0 0.0 7.8e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK37722.1 - 7.6e-07 28.7 0.2 1.6e-06 27.6 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK37722.1 - 0.0038 17.2 0.1 0.047 13.6 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK37722.1 - 0.0069 15.2 0.0 0.0069 15.2 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase Choline_kinase PF01633.20 PIK37722.1 - 0.0071 16.0 0.1 0.021 14.4 0.1 1.8 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 PIK37722.1 - 0.03 13.9 0.6 0.062 12.9 0.6 1.5 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 PIK37722.1 - 0.043 13.4 0.0 0.099 12.3 0.0 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 CTP_transf_1 PF01148.20 PIK37723.1 - 1.6e-58 198.5 7.8 1.9e-58 198.3 7.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family YvbH_ext PF11724.8 PIK37723.1 - 0.15 12.4 0.1 0.27 11.6 0.1 1.4 1 0 0 1 1 1 0 YvbH-like oligomerisation region PAP2_C PF14360.6 PIK37724.1 - 1.5e-26 92.7 11.0 1.5e-26 92.7 11.0 2.5 2 1 1 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 PIK37724.1 - 0.0032 17.2 13.0 0.0082 15.9 12.7 1.8 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 PIK37724.1 - 1.2 8.8 10.8 3 7.5 10.8 1.7 1 1 0 1 1 1 0 PAP2 superfamily DUF1011 PF06237.12 PIK37724.1 - 1.3 9.4 6.4 4.3 7.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) PTPlike_phytase PF14566.6 PIK37725.1 - 4.2e-44 150.4 0.1 9.8e-22 77.7 0.0 3.4 2 1 1 3 3 3 3 Inositol hexakisphosphate MOZ_SAS PF01853.18 PIK37726.1 - 1.1e-77 259.8 0.4 1.6e-77 259.2 0.4 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 PIK37726.1 - 1.5e-21 75.7 4.4 1.5e-21 75.7 4.4 2.4 2 0 0 2 2 2 1 MYST family zinc finger domain PHD PF00628.29 PIK37726.1 - 1.2e-16 60.3 27.1 3.2e-09 36.6 8.3 3.2 2 1 1 3 3 3 2 PHD-finger Acetyltransf_7 PF13508.7 PIK37726.1 - 0.011 16.1 0.0 0.065 13.7 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PHD_4 PF16866.5 PIK37726.1 - 0.13 12.3 21.3 0.41 10.8 6.4 3.4 1 1 1 2 2 2 0 PHD-finger PHD_2 PF13831.6 PIK37726.1 - 0.18 11.4 16.3 0.76 9.4 4.6 2.7 2 0 0 2 2 2 0 PHD-finger DUF3731 PF12531.8 PIK37726.1 - 1.4 8.7 4.3 3.1 7.5 4.3 1.6 1 0 0 1 1 1 0 DNA-K related protein Prok-RING_1 PF14446.6 PIK37726.1 - 5 7.1 19.6 3.6 7.6 9.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Mito_carr PF00153.27 PIK37727.1 - 1.1e-49 166.3 6.5 4e-23 81.1 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK37727.1 - 3.1e-05 23.3 2.3 0.069 12.3 0.0 3.5 2 2 0 3 3 3 2 Gammaproteobacterial serine protease EutK_C PF16365.5 PIK37727.1 - 0.03 14.4 0.0 0.31 11.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilization protein EutK C-terminus Dpy-30 PF05186.13 PIK37728.1 - 5.8e-14 51.5 0.0 8.2e-14 51.0 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Plasmodium_Vir PF05795.11 PIK37728.1 - 0.41 10.0 7.3 0.56 9.6 7.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM178 PF14816.6 PIK37728.1 - 0.5 9.3 3.4 0.67 8.9 3.4 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 Hid1 PF12722.7 PIK37728.1 - 4.7 5.2 7.7 6 4.9 7.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ribosomal_L1 PF00687.21 PIK37729.1 - 8.5e-13 48.5 0.1 1.5e-12 47.7 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DnaJ PF00226.31 PIK37730.1 - 3.2e-20 72.0 0.0 4.3e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain PC4 PF02229.16 PIK37731.1 - 3.5e-24 84.2 0.4 5.5e-24 83.5 0.4 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) DTHCT PF08070.11 PIK37731.1 - 0.0049 17.6 8.9 0.0075 17.0 8.9 1.3 1 0 0 1 1 1 1 DTHCT (NUC029) region SKA1 PF07160.12 PIK37731.1 - 0.12 12.2 1.7 0.16 11.8 0.4 1.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Gln-synt_C PF00120.24 PIK37732.1 - 5.3e-40 137.5 0.0 9.6e-18 64.3 0.0 3.1 3 0 0 3 3 3 3 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 PIK37732.1 - 2.8e-05 23.8 0.1 0.0004 20.1 0.1 2.3 1 1 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.5 PIK37732.1 - 0.028 14.2 0.0 0.096 12.5 0.0 1.8 2 0 0 2 2 2 0 Glutamine synthetase N-terminal domain GRIM-19 PF06212.12 PIK37733.1 - 1.9e-41 141.1 0.1 2.2e-41 140.9 0.1 1.0 1 0 0 1 1 1 1 GRIM-19 protein COX14 PF14880.6 PIK37733.1 - 0.097 12.5 0.3 10 6.1 0.1 2.4 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF4601 PF15373.6 PIK37734.1 - 1.8e-21 76.7 15.4 2.9e-21 75.9 15.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4601) CHASE9 PF17153.4 PIK37735.1 - 0.041 14.0 0.6 0.1 12.8 0.0 1.8 2 0 0 2 2 2 0 Periplasmic sensor domain, extracellular LTXXQ PF07813.12 PIK37735.1 - 0.099 13.4 1.5 0.68 10.7 0.0 2.4 2 0 0 2 2 2 0 LTXXQ motif family protein C2-set_2 PF08205.12 PIK37736.1 - 0.0026 17.8 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Pkinase_Tyr PF07714.17 PIK37737.1 - 2.7e-47 161.3 0.0 3.8e-47 160.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37737.1 - 1.5e-17 63.9 0.0 2.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 PIK37737.1 - 4.1e-06 26.8 0.0 8.4e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK37737.1 - 4.7e-06 27.1 0.0 9.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK37737.1 - 0.00088 19.4 0.1 0.0041 17.3 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK37737.1 - 0.0017 18.5 0.0 0.0039 17.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DUF4714 PF15833.5 PIK37737.1 - 0.097 12.6 0.2 3.5 7.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4714) Ig_2 PF13895.6 PIK37737.1 - 0.12 12.7 0.3 0.29 11.5 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain Vps39_1 PF10366.9 PIK37737.1 - 0.14 12.4 0.2 0.86 9.9 0.1 2.1 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Shisa PF13908.6 PIK37737.1 - 0.15 12.3 1.5 0.24 11.6 1.5 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ApoL PF05461.11 PIK37738.1 - 5.4e-14 52.2 7.0 1.2e-12 47.8 6.2 2.3 2 1 0 2 2 2 2 Apolipoprotein L SseC PF04888.12 PIK37738.1 - 0.093 12.3 8.1 0.61 9.6 5.4 2.2 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family RVT_1 PF00078.27 PIK37740.1 - 5.4e-23 81.7 0.1 8.1e-23 81.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK37740.1 - 6.7e-14 52.1 0.2 1.2e-13 51.2 0.2 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TrmB PF01978.19 PIK37740.1 - 0.021 14.7 0.0 0.088 12.7 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB RT_RNaseH_2 PF17919.1 PIK37740.1 - 0.036 14.1 0.1 0.071 13.1 0.1 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK37741.1 - 3.5e-25 88.5 0.0 6.3e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37741.1 - 1.7e-08 34.1 0.7 4e-08 32.9 0.2 1.8 2 0 0 2 2 2 1 Integrase core domain CAF1 PF04857.20 PIK37742.1 - 5e-74 249.3 1.1 5.7e-74 249.1 1.1 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.20 PIK37742.1 - 0.00022 21.0 0.1 0.016 15.0 0.1 2.4 2 0 0 2 2 2 1 3'-5' exonuclease DUF3784 PF12650.7 PIK37742.1 - 0.19 12.0 0.1 0.33 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) F_actin_bind PF08919.10 PIK37742.1 - 1.2 9.3 5.9 12 6.0 4.5 2.9 1 1 1 2 2 2 0 F-actin binding Trypsin PF00089.26 PIK37743.1 - 3.7e-23 82.5 0.1 5.1e-23 82.0 0.1 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK37743.1 - 0.0011 19.3 0.9 0.0025 18.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) Amidase_2 PF01510.25 PIK37744.1 - 1.5e-23 83.6 0.1 1.9e-23 83.3 0.1 1.1 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Amidase_2 PF01510.25 PIK37745.1 - 1.8e-14 54.3 0.1 2.1e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase PepSY_2 PF13670.6 PIK37745.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Lectin_C PF00059.21 PIK37746.1 - 3.2e-12 47.1 0.1 5.6e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain Synaptobrevin PF00957.21 PIK37747.1 - 3.8e-07 29.8 5.8 1.3e-05 24.8 0.4 2.2 1 1 1 2 2 2 2 Synaptobrevin Mobilization_B PF17511.2 PIK37747.1 - 0.14 12.5 2.0 0.16 12.3 2.0 1.1 1 0 0 1 1 1 0 Mobilization protein B La PF05383.17 PIK37748.1 - 1.5e-05 24.9 0.1 3.2e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 La domain ANAPC_CDC26 PF10471.9 PIK37748.1 - 2.8 8.8 9.3 13 6.7 9.3 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Macoilin PF09726.9 PIK37748.1 - 3.7 6.0 10.8 7.1 5.1 10.8 1.4 1 0 0 1 1 1 0 Macoilin family Sulfotransfer_1 PF00685.27 PIK37749.1 - 3.5e-24 85.7 0.2 4.4e-24 85.4 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK37749.1 - 1.5e-10 41.8 0.0 1.4e-09 38.7 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK37750.1 - 1e-06 28.4 0.0 1.7e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK37750.1 - 2.5e-05 24.8 0.1 0.00023 21.6 0.1 2.2 1 1 0 1 1 1 1 Sulfotransferase family CoA_transf_3 PF02515.17 PIK37750.1 - 0.091 11.9 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 CoA-transferase family III DUF3987 PF13148.6 PIK37753.1 - 4.3e-12 45.7 0.0 6e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) DDE_Tnp_IS1595 PF12762.7 PIK37754.1 - 1.4e-24 86.9 0.6 2.3e-24 86.1 0.6 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 PIK37754.1 - 0.00022 21.0 1.6 0.0008 19.2 0.1 2.5 2 1 1 3 3 3 1 DDE superfamily endonuclease RVT_1 PF00078.27 PIK37755.1 - 2.4e-21 76.3 0.0 3.3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TAFII55_N PF04658.13 PIK37756.1 - 3.8e-57 192.5 1.2 3.8e-57 192.5 1.2 1.9 2 1 0 2 2 2 1 TAFII55 protein conserved region HEPN_RES_NTD1 PF18870.1 PIK37757.1 - 4.6 7.5 9.9 0.094 12.9 0.5 3.1 3 0 0 3 3 3 0 HEPN/RES N-terminal domain 1 LRR_9 PF14580.6 PIK37758.1 - 2.8e-14 53.0 0.0 4.9e-14 52.2 0.0 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK37758.1 - 1.8e-06 28.2 8.4 0.0014 18.9 0.2 4.0 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK37758.1 - 2.9e-06 26.9 0.8 0.00057 19.6 0.2 3.2 2 1 2 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 PIK37758.1 - 0.36 11.0 5.1 1.1 9.4 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich repeat Presenilin PF01080.17 PIK37759.1 - 2.5 6.8 3.2 2.4 6.8 3.2 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 PIK37759.1 - 5 6.6 5.8 6.6 6.2 5.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 API5 PF05918.11 PIK37760.1 - 1.1e-80 271.9 5.6 2.9e-56 191.4 0.4 3.0 1 1 2 3 3 3 2 Apoptosis inhibitory protein 5 (API5) Adaptin_N PF01602.20 PIK37760.1 - 0.00049 18.8 0.2 0.00066 18.4 0.2 1.3 1 0 0 1 1 1 1 Adaptin N terminal region V_ATPase_I PF01496.19 PIK37760.1 - 0.0017 16.4 2.2 0.0021 16.1 2.2 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family HEAT_2 PF13646.6 PIK37760.1 - 0.0054 17.1 0.2 0.021 15.2 0.1 2.0 2 0 0 2 2 2 1 HEAT repeats Astro_capsid_p PF12226.8 PIK37760.1 - 0.0062 15.7 2.4 0.0084 15.3 2.4 1.2 1 0 0 1 1 1 1 Turkey astrovirus capsid protein DUF913 PF06025.12 PIK37760.1 - 0.021 13.8 1.8 0.038 13.0 1.8 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 PIK37760.1 - 0.1 12.3 2.0 0.15 11.8 2.0 1.2 1 0 0 1 1 1 0 Connexin RNA_pol_Rpc4 PF05132.14 PIK37760.1 - 0.16 12.4 6.6 0.27 11.6 6.6 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Cnd1 PF12717.7 PIK37760.1 - 0.19 11.7 0.5 0.53 10.3 0.5 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Zip PF02535.22 PIK37760.1 - 0.24 10.6 3.2 0.35 10.0 3.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SpoIIP PF07454.11 PIK37760.1 - 0.28 10.6 6.9 0.47 9.9 6.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pox_Ag35 PF03286.14 PIK37760.1 - 0.69 9.7 10.1 1.2 8.9 10.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein YqfQ PF14181.6 PIK37760.1 - 0.88 9.8 9.1 1.8 8.7 9.1 1.6 1 0 0 1 1 1 0 YqfQ-like protein TRAP_alpha PF03896.16 PIK37760.1 - 0.99 8.6 5.4 1.6 7.8 5.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TP53IP5 PF15331.6 PIK37760.1 - 1.1 9.4 10.6 6.4 6.9 10.2 2.0 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Merozoite_SPAM PF07133.11 PIK37760.1 - 2 8.4 24.8 4 7.4 24.8 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CobT PF06213.12 PIK37760.1 - 2 7.7 14.4 3.4 7.0 14.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT tRNA_bind_2 PF13725.6 PIK37760.1 - 2.7 7.6 8.6 33 4.1 8.2 2.1 2 0 0 2 2 2 0 Possible tRNA binding domain RR_TM4-6 PF06459.12 PIK37760.1 - 2.7 7.7 16.4 4.3 7.1 16.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 PIK37760.1 - 4 6.1 6.5 5.8 5.6 6.5 1.2 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 PIK37760.1 - 5.4 7.3 14.8 9.3 6.5 14.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 PIK37760.1 - 9.5 4.4 13.4 14 3.8 13.4 1.2 1 0 0 1 1 1 0 CDC45-like protein API5 PF05918.11 PIK37761.1 - 1.7e-54 185.6 0.3 2e-54 185.3 0.3 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) SHS2_Rpb7-N PF03876.17 PIK37762.1 - 1.3e-10 41.5 0.1 2.3e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 YccF PF03733.13 PIK37763.1 - 6.8e-17 61.9 16.5 6.8e-17 61.9 16.5 3.8 5 0 0 5 5 5 1 Inner membrane component domain Na_Ca_ex PF01699.24 PIK37763.1 - 1.1e-16 61.1 28.9 8.1e-14 51.8 14.3 3.6 4 0 0 4 4 4 2 Sodium/calcium exchanger protein YpzI PF14140.6 PIK37763.1 - 0.43 10.4 1.3 0.62 9.9 0.0 1.8 2 0 0 2 2 2 0 YpzI-like protein 60KD_IMP PF02096.20 PIK37763.1 - 5.3 6.9 6.5 1.4 8.8 2.1 2.2 3 0 0 3 3 3 0 60Kd inner membrane protein DNA_pol_B_exo1 PF03104.19 PIK37764.1 - 6.9e-23 81.3 0.0 3.4e-12 46.2 0.0 2.8 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 PIK37765.1 - 1.7e-99 333.6 0.0 2.7e-99 333.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 PIK37765.1 - 3.1e-19 69.2 7.9 6e-19 68.3 7.9 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta zf-C4H2 PF10146.9 PIK37765.1 - 0.049 13.9 0.0 0.085 13.2 0.0 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein zf_C2H2_6 PF18450.1 PIK37765.1 - 0.4 10.4 1.8 0.71 9.6 0.9 1.9 2 0 0 2 2 2 0 Zinc Finger domain DZR PF12773.7 PIK37765.1 - 0.92 9.6 7.1 0.47 10.5 1.4 2.0 1 1 1 2 2 2 0 Double zinc ribbon Prok-RING_1 PF14446.6 PIK37765.1 - 1.2 9.2 8.2 0.14 12.1 1.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 HypA PF01155.19 PIK37765.1 - 4.5 7.3 8.9 12 6.0 2.4 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ACC PF17848.1 PIK37765.1 - 5.3 7.2 11.9 2.2 8.4 0.1 4.0 3 1 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain DEP PF00610.21 PIK37766.1 - 5.5e-18 64.8 5.2 3.6e-17 62.2 0.2 2.1 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 PIK37767.1 - 1.8e-13 50.1 1.6 3.2e-13 49.3 1.6 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK37767.1 - 1.3e-10 41.5 1.5 1.9e-10 41.0 1.5 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK37767.1 - 4.9e-07 30.0 0.4 7.4e-07 29.4 0.4 1.4 1 0 0 1 1 1 1 PDZ domain SSXT PF05030.12 PIK37767.1 - 0.011 15.3 0.2 0.025 14.2 0.2 1.6 1 0 0 1 1 1 0 SSXT protein (N-terminal region) OCC1 PF15506.6 PIK37768.1 - 0.32 11.1 18.6 73 3.6 0.0 9.9 14 0 0 14 14 14 0 OCC1 family DUF1438 PF07270.11 PIK37768.1 - 1.1 9.4 7.6 8.1 6.5 0.3 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1438) Mac_assoc PF16628.5 PIK37768.1 - 2.2 8.5 19.3 11 6.2 3.9 3.8 1 1 3 4 4 4 0 Unstructured region on maltose acetyltransferase CDP-OH_P_transf PF01066.21 PIK37769.1 - 3.4e-16 59.8 0.3 3.4e-16 59.8 0.3 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Fibrinogen_C PF00147.18 PIK37770.1 - 6e-61 206.1 10.7 4.9e-43 147.5 0.8 2.6 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK37770.1 - 2.9e-09 37.0 31.6 2e-06 27.8 9.3 5.3 4 2 1 5 5 5 2 EGF domain TILa PF12714.7 PIK37770.1 - 9e-08 32.0 21.0 7.1e-06 25.9 4.9 4.3 2 1 2 4 4 4 2 TILa domain Caprin-1_C PF12287.8 PIK37770.1 - 0.00018 21.8 3.9 0.036 14.2 0.4 2.4 1 1 1 2 2 2 2 Cytoplasmic activation/proliferation-associated protein-1 C term EGF PF00008.27 PIK37770.1 - 0.021 15.1 6.0 0.021 15.1 6.0 4.6 5 0 0 5 5 5 0 EGF-like domain EGF_2 PF07974.13 PIK37770.1 - 0.22 12.0 47.4 0.052 13.9 10.0 4.9 4 0 0 4 4 4 0 EGF-like domain GldH_lipo PF14109.6 PIK37770.1 - 0.87 10.4 3.0 1.3 9.8 0.4 2.2 2 0 0 2 2 2 0 GldH lipoprotein Fibrinogen_C PF00147.18 PIK37771.1 - 1.5e-35 123.0 0.5 1.5e-34 119.7 0.7 2.0 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK37771.1 - 7e-07 29.3 7.8 7e-07 29.3 7.8 3.9 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK37771.1 - 0.00013 21.8 6.7 0.00013 21.8 6.7 3.5 1 1 2 3 3 3 1 TILa domain FXa_inhibition PF14670.6 PIK37771.1 - 8.8 6.7 24.5 1.8 8.9 7.0 3.1 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Fibrinogen_C PF00147.18 PIK37772.1 - 1.1e-57 195.3 0.1 4.5e-44 150.9 0.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK37772.1 - 5.5e-06 26.5 7.3 5.5e-06 26.5 7.3 2.6 2 1 0 2 2 2 1 EGF domain EGF_2 PF07974.13 PIK37772.1 - 0.015 15.7 17.2 0.062 13.7 5.6 3.7 3 1 0 3 3 3 0 EGF-like domain EGF PF00008.27 PIK37772.1 - 0.026 14.8 4.0 0.12 12.7 4.0 2.2 1 0 0 1 1 1 0 EGF-like domain EGF_CA PF07645.15 PIK37772.1 - 0.036 14.3 4.3 0.036 14.3 4.3 2.7 2 1 0 2 2 2 0 Calcium-binding EGF domain Metallothio_6 PF05522.11 PIK37772.1 - 5 7.7 17.0 1.4 9.5 13.8 1.8 1 1 0 1 1 1 0 Metallothionein cEGF PF12662.7 PIK37772.1 - 5.8 7.0 12.0 0.12 12.4 4.1 2.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK37772.1 - 7.7 6.9 18.8 1.4 9.3 5.4 2.7 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site Fibrinogen_C PF00147.18 PIK37773.1 - 8e-53 179.5 8.1 1.1e-50 172.5 8.1 2.2 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK37773.1 - 6.9e-07 29.4 7.8 6.9e-07 29.4 7.8 2.7 2 0 0 2 2 2 1 EGF domain TILa PF12714.7 PIK37773.1 - 0.00017 21.4 6.0 0.00017 21.4 6.0 2.7 2 0 0 2 2 2 2 TILa domain SH3_1 PF00018.28 PIK37774.1 - 2.1e-17 62.5 0.3 3.8e-17 61.6 0.3 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK37774.1 - 1.4e-15 56.9 0.2 2.4e-15 56.1 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK37774.1 - 1.1e-13 50.6 0.0 2.6e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain WD40 PF00400.32 PIK37774.1 - 0.0011 19.7 0.0 1.3 10.1 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37774.1 - 0.011 16.0 0.0 0.34 11.2 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1296 PF06972.11 PIK37775.1 - 2.5e-06 27.5 0.6 1.9e-05 24.7 0.3 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1296) UBA PF00627.31 PIK37775.1 - 0.00031 20.6 0.0 0.31 11.0 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain CUE PF02845.16 PIK37775.1 - 0.001 18.7 2.0 0.41 10.4 0.2 2.7 2 0 0 2 2 2 2 CUE domain HOIP-UBA PF16678.5 PIK37775.1 - 0.0063 16.5 0.5 0.41 10.6 0.1 2.4 2 0 0 2 2 2 1 HOIP UBA domain pair UBA_4 PF14555.6 PIK37775.1 - 0.017 14.9 0.0 0.8 9.6 0.0 2.5 2 0 0 2 2 2 0 UBA-like domain Iwr1 PF08574.10 PIK37775.1 - 0.29 12.2 0.1 0.29 12.2 0.1 3.1 2 1 0 2 2 2 0 Transcription factor Iwr1 RP-C_C PF11800.8 PIK37775.1 - 1.3 9.0 10.3 3.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region V-set PF07686.17 PIK37776.1 - 1.6e-12 47.6 0.6 7.9e-06 26.0 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK37776.1 - 1.1e-06 29.2 0.3 5.6 7.6 0.0 4.9 3 1 1 4 4 4 3 Immunoglobulin domain Herpes_gE PF02480.16 PIK37776.1 - 0.00031 19.6 2.2 0.17 10.6 0.1 3.4 3 1 0 4 4 4 3 Alphaherpesvirus glycoprotein E I-set PF07679.16 PIK37776.1 - 0.0037 17.3 0.0 6.8 6.8 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Pkinase_Tyr PF07714.17 PIK37777.1 - 1.8e-44 152.0 0.0 2.7e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37777.1 - 9.1e-15 54.7 0.0 1.5e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK37777.1 - 0.014 15.5 3.4 0.11 12.6 0.5 3.4 3 1 1 4 4 4 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK37777.1 - 0.039 14.3 1.4 0.15 12.4 0.3 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain ERM PF00769.19 PIK37778.1 - 3.4e-05 23.8 50.5 0.002 18.0 31.3 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family CCDC144C PF14915.6 PIK37778.1 - 0.0011 18.1 9.9 0.0011 18.1 9.9 2.4 2 1 0 2 2 2 1 CCDC144C protein coiled-coil region GAS PF13851.6 PIK37778.1 - 0.017 14.5 5.5 0.017 14.5 5.5 3.3 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Tmemb_cc2 PF10267.9 PIK37778.1 - 0.034 13.3 38.0 0.02 14.1 19.9 2.9 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Lebercilin PF15619.6 PIK37778.1 - 0.32 10.7 54.1 0.42 10.2 13.2 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease CagS PF16707.5 PIK37778.1 - 2.7 8.0 11.9 13 5.7 0.2 2.4 2 0 0 2 2 2 0 Cag pathogenicity island protein S of Helicobacter pylori DUF3573 PF12097.8 PIK37778.1 - 3 6.6 7.4 6.2 5.5 7.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) PI3K_P85_iSH2 PF16454.5 PIK37778.1 - 4 7.0 38.9 0.19 11.3 22.2 2.7 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Bacillus_HBL PF05791.11 PIK37778.1 - 4.7 7.0 27.1 0.13 12.1 12.3 3.0 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) HisKA_3 PF07730.13 PIK37778.1 - 6 7.5 19.8 13 6.4 0.6 4.5 2 2 2 4 4 4 0 Histidine kinase Tropomyosin_1 PF12718.7 PIK37778.1 - 6.7 6.9 51.3 1.9 8.6 11.4 3.7 2 2 0 2 2 2 0 Tropomyosin like Peptidase_S28 PF05577.12 PIK37778.1 - 7.1 5.3 9.5 2.6 6.7 4.9 2.0 1 1 1 2 2 2 0 Serine carboxypeptidase S28 DUF745 PF05335.13 PIK37778.1 - 8.1 6.1 31.8 0.053 13.2 4.8 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF745) MscS_porin PF12795.7 PIK37778.1 - 9.3 5.7 37.4 0.52 9.8 4.5 2.7 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain OCRL_clath_bd PF16726.5 PIK37779.1 - 0.016 15.4 0.5 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Inositol polyphosphate 5-phosphatase clathrin binding domain TPR_12 PF13424.6 PIK37779.1 - 0.025 14.9 3.4 1.4 9.3 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat ATLF PF07737.11 PIK37779.1 - 0.081 12.2 0.2 4.6 6.5 0.0 3.1 3 0 0 3 3 3 0 Anthrax toxin lethal factor, N- and C-terminal domain Gypsy PF07253.11 PIK37780.1 - 0.048 12.2 0.1 0.06 11.9 0.1 1.0 1 0 0 1 1 1 0 Gypsy protein WD40 PF00400.32 PIK37781.1 - 4.1e-07 30.6 3.9 0.014 16.2 0.1 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37781.1 - 0.0015 18.8 0.1 3 8.2 0.0 3.4 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK37781.1 - 0.017 14.1 0.1 0.029 13.3 0.1 1.5 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Tae4 PF14113.6 PIK37782.1 - 0.022 15.0 0.1 0.036 14.3 0.1 1.4 1 1 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 Myb_DNA-bind_6 PF13921.6 PIK37782.1 - 0.056 13.7 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF1891 PF09004.10 PIK37783.1 - 2.4e-13 49.4 1.9 4.5e-13 48.5 1.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) RVT_1 PF00078.27 PIK37783.1 - 3.3e-05 23.5 0.3 6.5e-05 22.6 0.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Claudin_2 PF13903.6 PIK37784.1 - 4.1e-05 23.4 0.7 5.3e-05 23.1 0.1 1.4 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Claudin_3 PF06653.11 PIK37784.1 - 0.00011 22.2 1.4 0.00011 22.2 1.4 1.8 2 1 0 2 2 2 1 Tight junction protein, Claudin-like SUR7 PF06687.12 PIK37784.1 - 0.029 14.0 2.4 0.065 12.9 0.1 2.0 2 0 0 2 2 2 0 SUR7/PalI family DHHC PF01529.20 PIK37784.1 - 4 7.5 7.0 16 5.6 0.1 2.6 2 1 0 2 2 2 0 DHHC palmitoyltransferase Sec16_N PF12935.7 PIK37785.1 - 1.8 8.7 11.1 3.8 7.6 11.1 1.5 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus MAP65_ASE1 PF03999.12 PIK37786.1 - 3.3e-100 336.5 23.0 6.6e-100 335.5 23.0 1.4 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Ank_4 PF13637.6 PIK37787.1 - 4.3e-11 43.1 0.1 0.00097 19.7 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK37787.1 - 7.6e-11 42.5 0.1 2.7e-06 27.9 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK37787.1 - 5.2e-10 39.4 0.1 0.002 18.4 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK37787.1 - 1.3e-07 31.3 0.3 0.014 15.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 PIK37787.1 - 1.9e-07 31.2 0.3 0.22 12.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat FERM_M PF00373.18 PIK37788.1 - 6.1e-05 23.4 0.2 0.00012 22.4 0.2 1.7 1 1 0 1 1 1 1 FERM central domain Ion_trans PF00520.31 PIK37789.1 - 2.8e-14 52.9 16.0 2.2e-13 50.0 16.0 2.0 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK37789.1 - 0.014 14.1 12.6 0.02 13.6 12.6 1.1 1 0 0 1 1 1 0 Polycystin cation channel Spectrin_like PF18373.1 PIK37789.1 - 0.043 13.9 0.7 0.099 12.7 0.7 1.6 1 0 0 1 1 1 0 Spectrin like domain EGF_CA PF07645.15 PIK37790.1 - 5e-14 52.2 49.8 3.1e-09 36.9 6.5 4.9 4 2 1 5 5 5 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK37790.1 - 4e-12 46.1 46.3 1.3e-08 34.8 11.7 4.7 4 1 0 4 4 4 3 EGF domain EGF PF00008.27 PIK37790.1 - 4.8e-06 26.8 52.8 0.047 14.0 11.2 5.5 5 0 0 5 5 5 4 EGF-like domain cEGF PF12662.7 PIK37790.1 - 9.4e-06 25.5 1.8 9.4e-06 25.5 1.8 6.7 5 2 0 5 5 5 3 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK37790.1 - 0.0022 18.0 7.9 0.0022 18.0 7.9 4.7 3 1 2 5 5 5 2 MSP1 EGF domain 1 FXa_inhibition PF14670.6 PIK37790.1 - 0.0028 17.9 51.7 0.051 13.9 8.0 4.7 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK37790.1 - 0.0069 17.0 15.2 0.021 15.5 1.9 6.2 5 1 1 6 6 6 2 Human growth factor-like EGF RepC PF06504.11 PIK37791.1 - 0.23 10.7 0.0 0.24 10.6 0.0 1.0 1 0 0 1 1 1 0 Replication protein C (RepC) Transposase_24 PF03004.14 PIK37792.1 - 1.8e-26 92.9 0.1 6.1e-26 91.2 0.0 1.7 2 0 0 2 2 2 1 Plant transposase (Ptta/En/Spm family) DUF4216 PF13952.6 PIK37793.1 - 7.7e-12 45.4 0.0 1.6e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4216) DUF3785 PF12653.7 PIK37793.1 - 0.46 10.6 4.3 0.43 10.7 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3785) CAML PF14963.6 PIK37794.1 - 1.4 9.0 6.7 3.6 7.6 0.4 2.2 1 1 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Metal_resist PF13801.6 PIK37796.1 - 1.2 9.3 5.8 0.36 11.0 1.9 1.9 2 0 0 2 2 2 0 Heavy-metal resistance PP2C_C PF07830.13 PIK37796.1 - 3.2 8.3 5.1 2 8.9 0.5 2.2 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Exonuc_VII_L PF02601.15 PIK37796.1 - 8.9 5.8 10.5 11 5.5 10.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4464 PF14713.6 PIK37798.1 - 1.3e-89 299.6 1.1 2.1e-89 298.9 1.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4464) TGF_beta PF00019.20 PIK37799.1 - 9.2e-29 100.5 2.3 1.2e-28 100.1 0.5 2.1 2 0 0 2 2 2 1 Transforming growth factor beta like domain AAA_23 PF13476.6 PIK37799.1 - 0.013 16.0 8.6 0.02 15.4 8.6 1.3 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.31 PIK37800.1 - 7.1e-21 74.1 0.1 9.8e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L1 PF00687.21 PIK37801.1 - 8.4e-13 48.5 0.1 1.5e-12 47.7 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Dpy-30 PF05186.13 PIK37802.1 - 5.7e-10 38.7 0.0 8.7e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif DUF4355 PF14265.6 PIK37802.1 - 0.15 12.3 11.9 0.25 11.6 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) FAM178 PF14816.6 PIK37802.1 - 0.48 9.3 3.5 0.56 9.1 3.5 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 Ribosomal_L6e_N PF03868.15 PIK37803.1 - 0.0044 17.2 0.1 0.0086 16.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L6, N-terminal domain Exo_endo_phos_2 PF14529.6 PIK37803.1 - 0.024 14.5 0.5 0.074 12.9 0.0 2.0 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase Na_H_Exchanger PF00999.21 PIK37804.1 - 7.4e-57 192.9 48.6 9.5e-57 192.5 48.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Alpha-amylase PF00128.24 PIK37804.1 - 0.014 14.9 3.0 0.021 14.4 3.0 1.2 1 0 0 1 1 1 0 Alpha amylase, catalytic domain FlgT_M PF16539.5 PIK37804.1 - 0.57 10.3 3.0 5.1 7.2 2.8 2.6 3 1 0 3 3 3 0 Flagellar assembly protein T, middle domain IL2 PF00715.17 PIK37804.1 - 1 9.3 7.3 0.55 10.2 2.3 2.5 2 0 0 2 2 2 0 Interleukin 2 GCP_N_terminal PF17681.1 PIK37805.1 - 1.5e-86 290.8 0.1 4.9e-86 289.1 0.1 1.8 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 PIK37805.1 - 6.2e-82 275.5 12.8 1.4e-81 274.3 12.8 1.7 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal PQ-loop PF04193.14 PIK37806.1 - 1.7e-16 59.7 15.1 9.3e-13 47.8 1.1 3.2 3 0 0 3 3 3 2 PQ loop repeat EGF_2 PF07974.13 PIK37808.1 - 0.0011 19.2 7.0 0.002 18.4 7.0 1.4 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 PIK37808.1 - 0.011 16.0 4.8 0.022 15.1 4.8 1.4 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 PIK37808.1 - 0.021 15.5 5.7 0.037 14.7 3.7 2.2 2 0 0 2 2 2 0 Human growth factor-like EGF S_locus_glycop PF00954.20 PIK37808.1 - 0.5 10.9 4.5 0.72 10.4 4.5 1.3 1 0 0 1 1 1 0 S-locus glycoprotein domain CD225 PF04505.12 PIK37809.1 - 3.4e-15 55.9 0.1 5.5e-15 55.3 0.1 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 PIK37809.1 - 0.027 14.2 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4190) Sugar_tr PF00083.24 PIK37810.1 - 1.6e-26 93.2 19.4 2e-26 92.9 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK37810.1 - 2.3e-17 63.0 32.0 1.8e-14 53.4 17.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Cyclin_N PF00134.23 PIK37810.1 - 0.11 12.3 0.0 9.9 5.9 0.0 2.3 2 0 0 2 2 2 0 Cyclin, N-terminal domain OATP PF03137.20 PIK37810.1 - 0.12 10.7 11.1 0.57 8.4 0.6 2.9 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family LRR_8 PF13855.6 PIK37812.1 - 3.4e-45 151.6 81.8 3e-14 52.5 3.5 5.4 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK37812.1 - 3.1e-20 71.9 55.3 5.9e-06 26.5 1.7 7.4 4 1 5 9 9 9 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37812.1 - 2.8e-14 53.2 7.8 2.6e-07 30.7 1.7 2.8 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37812.1 - 1.2e-08 34.7 20.9 0.0042 16.6 2.0 4.4 1 1 4 5 5 5 5 Leucine-rich repeat LRRNT PF01462.18 PIK37812.1 - 0.0092 15.6 5.0 0.11 12.2 1.4 3.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK37812.1 - 0.26 12.0 0.2 0.26 12.0 0.2 11.8 12 1 0 12 12 12 0 Leucine Rich Repeat DUF4144 PF13642.6 PIK37813.1 - 0.017 15.7 0.2 0.034 14.7 0.2 1.4 1 0 0 1 1 1 0 protein structure with unknown function LRR_8 PF13855.6 PIK37814.1 - 3.1e-27 94.1 33.3 8.6e-15 54.2 4.8 4.5 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK37814.1 - 1.9e-16 59.8 35.6 1.8e-05 25.0 1.7 6.2 3 2 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37814.1 - 1.5e-11 44.3 4.6 3.2e-06 27.1 0.6 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37814.1 - 0.00011 21.8 13.4 0.12 11.9 1.0 3.5 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK37814.1 - 0.003 17.9 35.4 1.5 9.6 0.1 8.9 7 3 1 8 8 8 2 Leucine Rich Repeat LRRNT PF01462.18 PIK37814.1 - 0.0095 15.6 3.0 0.11 12.1 1.4 2.9 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 PIK37814.1 - 3.2 8.1 29.3 7.3 6.9 0.3 6.9 7 0 0 7 7 7 0 Leucine Rich repeat LRR_8 PF13855.6 PIK37815.1 - 1.5e-39 133.6 70.4 1.2e-13 50.6 4.5 5.7 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK37815.1 - 9.4e-18 64.0 48.1 1.9e-05 24.9 3.0 7.4 4 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37815.1 - 7.2e-14 51.9 2.5 2.6e-06 27.4 0.3 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37815.1 - 9.4e-07 28.5 20.2 0.0011 18.6 2.4 4.5 1 1 4 5 5 5 4 Leucine-rich repeat Orthopox_F6 PF06601.12 PIK37815.1 - 0.019 15.1 0.4 0.052 13.7 0.4 1.7 1 0 0 1 1 1 0 Orthopoxvirus F6 protein LRR_1 PF00560.33 PIK37815.1 - 0.25 12.0 0.2 0.25 12.0 0.2 11.1 9 4 2 11 11 11 0 Leucine Rich Repeat LRRNT PF01462.18 PIK37815.1 - 0.33 10.7 4.8 2 8.2 1.1 3.3 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Vinculin PF01044.19 PIK37817.1 - 2.4e-88 297.6 1.4 2.8e-88 297.3 1.4 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 PIK37817.1 - 0.001 19.3 3.4 0.001 19.3 3.4 2.0 1 1 0 2 2 2 1 I/LWEQ domain PFL-like PF02901.15 PIK37817.1 - 0.031 12.9 0.7 0.041 12.5 0.7 1.1 1 0 0 1 1 1 0 Pyruvate formate lyase-like BAR_3 PF16746.5 PIK37817.1 - 0.12 12.0 0.5 0.7 9.6 0.1 1.9 2 0 0 2 2 2 0 BAR domain of APPL family OrfB_IS605 PF01385.19 PIK37821.1 - 0.0084 16.3 0.4 0.014 15.6 0.4 1.4 1 1 0 1 1 1 1 Probable transposase Limkain-b1 PF11608.8 PIK37821.1 - 0.059 13.4 0.1 0.096 12.8 0.1 1.4 1 0 0 1 1 1 0 Limkain b1 OEP PF02321.18 PIK37822.1 - 0.0044 16.8 36.7 0.47 10.2 23.4 3.0 1 1 1 2 2 2 2 Outer membrane efflux protein DHR10 PF18595.1 PIK37822.1 - 0.047 13.8 0.8 0.047 13.8 0.8 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain GAS PF13851.6 PIK37822.1 - 0.11 11.8 8.6 0.93 8.8 1.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 PIK37822.1 - 0.15 9.5 31.1 2.9 5.3 14.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Tropomyosin PF00261.20 PIK37822.1 - 0.46 9.8 12.9 0.67 9.3 12.9 1.3 1 0 0 1 1 1 0 Tropomyosin Tropomyosin_1 PF12718.7 PIK37822.1 - 2 8.6 14.5 22 5.2 14.2 2.1 1 1 0 1 1 1 0 Tropomyosin like DUF4472 PF14739.6 PIK37822.1 - 2.9 8.7 17.9 3.3 8.5 7.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) ATG16 PF08614.11 PIK37822.1 - 3.8 7.7 20.2 6.4 6.9 20.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 PIK37822.1 - 4 7.5 39.2 7.8 6.6 17.8 2.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 PIK37822.1 - 4.9 6.9 18.6 6.7 6.4 18.6 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family YlqD PF11068.8 PIK37822.1 - 5.8 7.3 15.3 1.4e+03 -0.4 15.3 2.4 1 1 0 1 1 1 0 YlqD protein Macoilin PF09726.9 PIK37822.1 - 7.5 5.0 22.3 8.4 4.8 22.3 1.0 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 PIK37822.1 - 8.4 4.4 17.0 10 4.1 17.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_A17 PF05380.13 PIK37824.1 - 9.7e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF5588 PF17826.1 PIK37825.1 - 1.8e-09 36.9 8.6 4e-09 35.8 2.1 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5588) TPR_12 PF13424.6 PIK37825.1 - 2.2e-05 24.7 7.9 0.0023 18.2 2.8 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK37825.1 - 0.0017 18.4 0.9 4.2 7.8 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK37825.1 - 0.012 15.7 3.8 5.1 7.5 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK37825.1 - 0.35 11.5 1.1 8.5 7.1 0.4 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK37825.1 - 0.54 10.5 3.4 0.94 9.8 0.4 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TUDOR PF00567.24 PIK37826.1 - 3.9e-78 259.3 2.0 1.1e-25 90.0 0.0 3.7 4 0 0 4 4 4 3 Tudor domain Agenet PF05641.12 PIK37826.1 - 1.5e-05 25.3 0.4 1.4 9.5 0.0 3.8 3 0 0 3 3 3 2 Agenet domain DUF4537 PF15057.6 PIK37826.1 - 0.00011 22.2 0.0 1.5 8.8 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4537) TUDOR PF00567.24 PIK37827.1 - 2.9e-38 130.6 0.0 8.8e-18 64.5 0.0 2.5 2 0 0 2 2 2 2 Tudor domain SMN PF06003.12 PIK37827.1 - 6.8e-05 22.2 0.3 0.02 14.1 0.0 2.1 2 0 0 2 2 2 2 Survival motor neuron protein (SMN) Agenet PF05641.12 PIK37827.1 - 0.0015 18.9 0.6 1.8 9.1 0.1 2.4 2 0 0 2 2 2 2 Agenet domain DUF4537 PF15057.6 PIK37827.1 - 0.046 13.7 0.2 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) TUDOR PF00567.24 PIK37828.1 - 1.3e-13 51.1 0.0 2.4e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Tudor domain SecD-TM1 PF13721.6 PIK37828.1 - 0.11 13.0 0.2 0.56 10.7 0.1 2.3 2 1 0 2 2 2 0 SecD export protein N-terminal TM region DUF2187 PF09953.9 PIK37828.1 - 0.14 12.2 4.8 3.3 7.8 0.2 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2187) NGP1NT PF08153.12 PIK37829.1 - 6.6e-34 116.9 0.8 1.2e-33 116.1 0.8 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 PIK37829.1 - 8.3e-17 61.3 0.1 1.4e-13 51.0 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK37829.1 - 4.5e-06 26.3 0.1 1.2e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK37829.1 - 6.1e-05 23.0 0.0 0.00017 21.5 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 PIK37829.1 - 0.0013 18.8 1.0 2.7 8.0 0.1 3.5 2 2 1 3 3 3 2 Dynamin family Arf PF00025.21 PIK37829.1 - 0.04 13.4 0.1 0.33 10.4 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family CDC45 PF02724.14 PIK37830.1 - 1.3 7.2 12.0 1.7 6.9 12.0 1.2 1 0 0 1 1 1 0 CDC45-like protein NCE101 PF11654.8 PIK37831.1 - 6.9 6.5 5.9 1.4 8.7 2.0 1.8 2 0 0 2 2 2 0 Non-classical export protein 1 F-box-like PF12937.7 PIK37832.1 - 5.5e-06 26.2 2.1 5.5e-06 26.2 2.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK37832.1 - 0.13 12.2 3.6 0.089 12.7 0.7 2.3 2 0 0 2 2 2 0 F-box domain Glutaredoxin PF00462.24 PIK37833.1 - 2.5e-16 59.6 0.1 5.3e-16 58.6 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.6 PIK37833.1 - 6.7e-05 23.2 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DEP PF00610.21 PIK37833.1 - 0.00015 21.7 0.0 0.00029 20.8 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF836 PF05768.14 PIK37833.1 - 0.018 15.5 0.2 0.035 14.5 0.2 1.7 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.6 PIK37833.1 - 0.022 14.9 0.2 0.22 11.7 0.1 2.2 1 1 1 2 2 2 0 Thioredoxin Fcf2 PF08698.11 PIK37833.1 - 0.12 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Fcf2 pre-rRNA processing Thioredoxin PF00085.20 PIK37833.1 - 0.16 11.9 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin RVT_1 PF00078.27 PIK37834.1 - 2.8e-33 115.3 0.1 4.4e-33 114.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK37834.1 - 4e-05 23.6 0.1 8.2e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Flu_PB1 PF00602.17 PIK37834.1 - 0.13 10.3 0.0 0.17 10.0 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Ig_3 PF13927.6 PIK37835.1 - 0.00024 21.6 0.0 0.00038 21.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK37835.1 - 0.0042 17.1 0.0 0.0058 16.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK37835.1 - 0.0078 16.4 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK37835.1 - 0.019 15.2 0.1 0.043 14.0 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK37835.1 - 0.12 12.7 0.2 2.9 8.2 0.2 2.2 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain F-box-like PF12937.7 PIK37836.1 - 0.017 15.0 0.3 0.05 13.5 0.3 1.8 1 0 0 1 1 1 0 F-box-like adh_short PF00106.25 PIK37837.1 - 2.6e-22 79.2 0.0 4e-22 78.6 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37837.1 - 2.3e-13 50.3 0.0 3.5e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK37837.1 - 1e-06 28.8 0.1 1.5e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 KR domain DFP PF04127.15 PIK37837.1 - 0.0016 18.3 0.1 0.003 17.4 0.1 1.4 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Lig_chan PF00060.26 PIK37839.1 - 3.5e-27 95.1 0.0 4.3e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel CCT_2 PF09425.10 PIK37839.1 - 0.12 12.2 0.6 0.24 11.3 0.6 1.4 1 0 0 1 1 1 0 Divergent CCT motif DUF2371 PF10177.9 PIK37841.1 - 4.1e-09 36.7 0.8 4.1e-09 36.7 0.8 2.3 2 1 0 2 2 2 1 Uncharacterised conserved protein (DUF2371) Neurensin PF14927.6 PIK37841.1 - 0.00081 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 Neurensin Deltameth_res PF16020.5 PIK37841.1 - 0.19 11.6 0.1 0.43 10.5 0.1 1.5 1 0 0 1 1 1 0 Deltamethrin resistance UPAR_LY6 PF00021.21 PIK37842.1 - 0.041 14.6 6.4 0.25 12.1 6.4 2.2 1 1 0 1 1 1 0 u-PAR/Ly-6 domain adh_short PF00106.25 PIK37843.1 - 2.9e-11 43.2 0.0 3.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37843.1 - 0.0021 17.7 0.0 0.0025 17.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF728 PF05304.12 PIK37844.1 - 0.13 12.1 1.2 0.24 11.2 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF728) mTERF PF02536.14 PIK37845.1 - 1.4e-24 86.6 5.6 1.9e-24 86.2 5.6 1.1 1 0 0 1 1 1 1 mTERF SKA2 PF16740.5 PIK37845.1 - 0.064 13.0 1.1 6 6.7 0.0 3.1 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Itfg2 PF15907.5 PIK37846.1 - 2.7e-61 207.4 0.5 5.2e-60 203.3 0.1 2.0 2 0 0 2 2 2 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 PIK37846.1 - 7e-07 29.3 0.1 0.07 13.2 0.0 2.9 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 PIK37846.1 - 0.067 13.8 0.2 6.4 7.4 0.0 3.1 2 1 2 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK37846.1 - 0.49 10.6 2.6 1.1 9.4 0.4 2.3 2 0 0 2 2 2 0 FG-GAP repeat LRR_8 PF13855.6 PIK37847.1 - 4.7e-11 42.3 0.1 7.7e-11 41.6 0.1 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 PIK37847.1 - 0.0013 19.1 13.8 0.0033 17.8 2.2 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37847.1 - 0.0018 18.3 0.1 0.0034 17.3 0.1 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 PIK37847.1 - 0.041 13.6 2.4 0.11 12.1 2.4 1.9 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK37847.1 - 0.078 13.6 4.2 0.67 10.7 0.1 3.6 3 2 0 3 3 3 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK37847.1 - 0.22 11.0 0.0 0.32 10.5 0.0 1.1 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 PIK37847.1 - 0.44 10.7 3.3 3.4 7.9 1.5 2.7 2 0 0 2 2 2 0 Leucine Rich repeat Fibrinogen_C PF00147.18 PIK37848.1 - 1.1e-39 136.5 1.2 1.1e-39 136.5 1.2 1.7 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK37848.1 - 0.0016 18.6 17.2 0.11 12.8 17.2 2.9 1 1 0 1 1 1 1 EGF domain baeRF_family11 PF18855.1 PIK37848.1 - 0.063 13.6 0.3 9 6.6 0.1 2.1 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 TILa PF12714.7 PIK37848.1 - 0.15 12.0 8.0 0.42 10.6 7.7 1.9 1 1 0 1 1 1 0 TILa domain EGF_2 PF07974.13 PIK37848.1 - 1.3 9.4 11.6 1.9 8.9 10.5 2.0 1 1 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK37850.1 - 2e-46 158.6 15.2 3e-45 154.7 15.2 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK37850.1 - 3.3e-09 36.5 11.7 3.3e-09 36.5 11.7 4.7 3 1 1 4 4 4 1 TILa domain TIL PF01826.17 PIK37850.1 - 1.5e-06 28.3 12.8 1.5e-06 28.3 12.8 4.3 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK37851.1 - 1.9e-10 40.5 12.6 1.9e-10 40.5 12.6 3.4 1 1 1 2 2 2 1 TILa domain TIL PF01826.17 PIK37851.1 - 1.7e-06 28.1 11.8 1.7e-06 28.1 11.8 3.4 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK37851.1 - 0.0028 17.8 15.2 0.0028 17.8 15.2 4.2 2 2 1 3 3 3 2 EGF domain EGF_MSP1_1 PF12946.7 PIK37851.1 - 0.0052 16.8 9.8 0.0052 16.8 9.8 3.4 3 1 0 3 3 3 1 MSP1 EGF domain 1 SRCR PF00530.18 PIK37852.1 - 1.1e-59 199.2 16.9 1.1e-29 102.9 2.8 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK37852.1 - 1.6e-14 54.2 4.2 2.2e-06 28.1 0.1 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK37852.1 - 5.9e-07 30.0 0.0 0.06 13.9 0.0 2.4 2 0 0 2 2 2 2 Hepsin, SRCR domain Moricin PF06451.11 PIK37852.1 - 0.0028 17.4 0.1 17 5.3 0.0 3.7 3 0 0 3 3 3 2 Moricin Pelovaterin PF17859.1 PIK37852.1 - 0.2 12.0 5.9 4.3 7.7 0.8 3.3 2 0 0 2 2 2 0 Pelovaterin Ank_2 PF12796.7 PIK37853.1 - 1.1e-102 336.8 23.6 1.3e-16 60.9 0.1 7.7 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 PIK37853.1 - 2.5e-68 223.7 21.5 1.3e-05 25.4 0.0 14.3 14 0 0 14 14 14 13 Ankyrin repeat Ank_4 PF13637.6 PIK37853.1 - 3.5e-66 218.8 10.6 1.7e-14 54.0 0.3 10.2 4 3 7 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK37853.1 - 1.7e-64 206.1 6.6 0.00022 21.4 0.0 14.0 14 0 0 14 14 14 13 Ankyrin repeat Ank_5 PF13857.6 PIK37853.1 - 1.2e-60 200.7 14.1 1.5e-07 31.6 0.1 12.7 3 2 11 14 14 14 12 Ankyrin repeats (many copies) VWA_3_C PF18571.1 PIK37853.1 - 0.046 13.6 10.0 4.6 7.2 0.0 6.0 8 0 0 8 8 8 0 von Willebrand factor type A C-terminal domain RRF PF01765.19 PIK37855.1 - 0.0015 18.5 0.1 0.0021 18.0 0.1 1.2 1 0 0 1 1 1 1 Ribosome recycling factor T3SSipB PF16535.5 PIK37855.1 - 0.016 15.7 1.6 0.023 15.2 1.6 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF1877 PF08974.10 PIK37855.1 - 0.09 12.9 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Glyco_hydro_42M PF08532.10 PIK37855.1 - 0.11 11.9 0.1 24 4.3 0.0 2.7 3 0 0 3 3 3 0 Beta-galactosidase trimerisation domain DUF2443 PF10398.9 PIK37855.1 - 0.16 12.1 0.9 1.2 9.3 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) DUF4175 PF13779.6 PIK37855.1 - 0.27 9.1 3.0 0.36 8.7 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) 3HCDH_N PF02737.18 PIK37856.1 - 2.8e-63 213.0 0.1 4.7e-63 212.3 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 PIK37856.1 - 2.4e-31 108.2 0.0 2.6e-24 85.7 0.0 3.1 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_1 PF00378.20 PIK37856.1 - 2.3e-05 23.8 0.0 9.5e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Pyr_redox_2 PF07992.14 PIK37856.1 - 0.0032 16.8 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 PIK37856.1 - 0.0062 16.5 0.0 0.019 15.0 0.0 1.8 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 PIK37856.1 - 0.011 15.4 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 PIK37856.1 - 0.042 14.4 0.1 0.13 12.9 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 PIK37856.1 - 0.054 13.7 0.1 0.14 12.4 0.1 1.7 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase zf-CCCH PF00642.24 PIK37857.1 - 2.9e-08 33.4 30.0 1e-05 25.3 1.6 3.7 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 PIK37857.1 - 9.6e-08 31.7 20.7 3.3e-05 23.6 3.1 3.8 4 0 0 4 4 4 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 PIK37857.1 - 1e-07 31.8 16.9 6.1e-05 22.9 5.2 3.9 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_2 PF14608.6 PIK37857.1 - 9.3e-07 29.1 22.0 0.0011 19.3 0.9 3.6 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 PIK37857.1 - 0.00011 22.4 14.2 0.0028 17.8 8.9 2.4 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.5 PIK37857.1 - 0.0014 19.3 15.9 0.009 16.7 0.5 3.5 1 1 2 3 3 3 2 Torus domain NRBF2 PF08961.10 PIK37857.1 - 0.068 12.8 1.0 0.12 12.0 1.0 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator TPR_MLP1_2 PF07926.12 PIK37857.1 - 0.069 13.2 2.1 0.12 12.5 2.1 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TSC22 PF01166.18 PIK37857.1 - 0.22 11.9 0.9 0.41 11.0 0.5 1.7 1 1 0 1 1 1 0 TSC-22/dip/bun family bZIP_2 PF07716.15 PIK37857.1 - 7.7 6.7 9.3 3.5 7.8 1.7 3.1 2 1 1 3 3 3 0 Basic region leucine zipper zf_CCCH_4 PF18345.1 PIK37858.1 - 2.3e-09 37.0 23.3 9.9e-05 22.3 5.5 3.8 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 PIK37858.1 - 1.7e-08 34.1 24.5 4.5e-06 26.4 0.8 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 PIK37858.1 - 1.7e-07 31.4 9.0 6.5e-05 23.1 5.0 2.3 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 PIK37858.1 - 3.2e-07 30.6 26.0 0.003 18.0 2.3 3.4 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 PIK37858.1 - 5.8e-06 26.0 24.2 0.001 18.8 3.5 3.6 3 1 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 PIK37858.1 - 0.00027 21.6 16.1 0.027 15.1 0.5 3.3 1 1 2 3 3 3 2 Torus domain bZIP_2 PF07716.15 PIK37858.1 - 0.00049 20.1 3.2 0.18 11.9 0.1 2.5 1 1 1 2 2 2 2 Basic region leucine zipper TSC22 PF01166.18 PIK37858.1 - 0.0019 18.5 0.6 0.0041 17.4 0.5 1.6 1 1 0 1 1 1 1 TSC-22/dip/bun family NRBF2 PF08961.10 PIK37858.1 - 0.01 15.5 0.5 0.017 14.7 0.5 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator HALZ PF02183.18 PIK37858.1 - 0.022 15.0 2.8 0.67 10.2 3.0 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 PIK37858.1 - 0.038 14.4 0.8 0.067 13.6 0.8 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Shugoshin_N PF07558.11 PIK37858.1 - 0.042 13.7 1.0 0.26 11.2 0.8 2.1 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region KASH_CCD PF14662.6 PIK37858.1 - 0.056 13.3 1.7 0.082 12.7 1.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Med9 PF07544.13 PIK37858.1 - 0.11 12.6 0.2 0.28 11.3 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Spc7 PF08317.11 PIK37858.1 - 0.14 11.1 0.5 0.19 10.6 0.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 PIK37858.1 - 0.23 12.0 1.6 0.37 11.3 1.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CoaE PF01121.20 PIK37859.1 - 1.9e-60 203.6 0.0 2.4e-60 203.3 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 PIK37859.1 - 0.00039 21.0 0.6 0.0056 17.2 0.3 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 PIK37859.1 - 0.016 15.4 0.0 0.2 11.8 0.0 2.3 1 1 0 1 1 1 0 AAA domain SKI PF01202.22 PIK37859.1 - 0.12 12.5 0.3 1.6 8.8 0.3 2.3 1 1 0 1 1 1 0 Shikimate kinase AAA_28 PF13521.6 PIK37859.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 PIK37859.1 - 0.18 12.2 0.1 2.9 8.3 0.1 2.5 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.22 PIK37860.1 - 0.0064 16.3 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK37860.1 - 0.018 14.6 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 PIK37860.1 - 0.043 13.9 1.2 0.66 10.1 0.0 2.3 1 1 1 2 2 2 0 Limkain b1 NMT PF01233.19 PIK37862.1 - 1.2e-74 249.5 0.0 1.9e-74 248.8 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 PIK37862.1 - 0.0032 17.7 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 PIK37862.1 - 0.081 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK37862.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NST1 PF13945.6 PIK37862.1 - 5.7 7.0 7.8 1.1 9.3 3.8 1.7 1 1 1 2 2 2 0 Salt tolerance down-regulator LANC_like PF05147.13 PIK37863.1 - 4.5e-86 288.6 0.3 5.8e-86 288.2 0.3 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.13 PIK37863.1 - 0.013 15.0 1.4 0.15 11.5 0.2 2.7 2 1 1 3 3 3 0 D-glucuronyl C5-epimerase C-terminus DUF4844 PF16133.5 PIK37863.1 - 0.11 13.0 0.1 0.3 11.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) DUF5436 PF17504.2 PIK37863.1 - 0.16 12.3 0.1 2.2 8.7 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5436) Tim54 PF11711.8 PIK37863.1 - 0.17 10.6 0.0 3.3 6.4 0.1 2.1 1 1 1 2 2 2 0 Inner membrane protein import complex subunit Tim54 F5_F8_type_C PF00754.25 PIK37864.1 - 5.3e-19 68.6 0.0 7.3e-08 32.6 0.0 4.8 5 0 0 5 5 5 4 F5/8 type C domain F5_F8_type_C PF00754.25 PIK37865.1 - 2.6e-14 53.4 0.0 3.7e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain PSI PF01437.25 PIK37866.1 - 0.00017 22.0 10.4 0.00026 21.5 10.4 1.3 1 0 0 1 1 1 1 Plexin repeat RVT_1 PF00078.27 PIK37868.1 - 1.5e-42 145.7 0.3 2.4e-42 145.0 0.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ABC_tran PF00005.27 PIK37869.1 - 3.8e-18 66.3 0.0 6.9e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK37869.1 - 0.00032 20.2 0.1 0.14 11.5 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 PIK37869.1 - 0.003 18.1 0.0 0.0046 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 PIK37869.1 - 0.0047 16.8 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK37869.1 - 0.022 14.5 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 PIK37869.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 PIK37869.1 - 0.083 13.4 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK37869.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 PIK37869.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Cyto_heme_lyase PF01265.17 PIK37869.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase AAA_15 PF13175.6 PIK37869.1 - 0.21 11.2 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain rve PF00665.26 PIK37871.1 - 3.1e-23 82.2 0.0 6.8e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK37871.1 - 1.8e-22 79.2 0.7 3.4e-22 78.3 0.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK37871.1 - 0.0041 16.9 0.1 0.013 15.3 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK37871.1 - 0.0042 17.3 0.3 0.018 15.2 0.3 2.2 1 0 0 1 1 1 1 H2C2 zinc finger IMUP PF15761.5 PIK37871.1 - 0.075 13.7 0.4 0.18 12.5 0.4 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein RVT_1 PF00078.27 PIK37872.1 - 3.6e-29 101.8 0.0 4.7e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.12 PIK37873.1 - 0.014 15.2 0.6 0.024 14.5 0.6 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Beach PF02138.18 PIK37874.1 - 4e-99 331.5 2.9 5.4e-99 331.0 2.9 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 PIK37874.1 - 4.8e-19 68.3 0.0 1.3e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 PIK37874.1 - 5.9e-10 39.6 5.1 0.012 16.5 0.1 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37874.1 - 0.012 15.9 0.1 4.6 7.6 0.0 3.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain L51_S25_CI-B8 PF05047.16 PIK37874.1 - 0.028 14.3 0.0 0.34 10.9 0.0 2.6 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF295 PF03478.18 PIK37875.1 - 0.00067 19.2 0.6 12 5.6 0.0 5.3 3 2 0 3 3 3 2 Protein of unknown function (DUF295) TrkA_C PF02080.21 PIK37875.1 - 0.098 12.5 2.7 1.1e+02 2.7 0.0 5.1 5 1 0 5 5 5 0 TrkA-C domain WD40 PF00400.32 PIK37876.1 - 9e-15 54.8 12.8 8.6e-05 23.2 0.2 5.9 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37876.1 - 0.039 14.3 0.0 1.1 9.7 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK37876.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain EamA PF00892.20 PIK37877.1 - 2.8e-26 92.3 44.3 7.3e-17 61.8 14.4 2.0 2 0 0 2 2 2 2 EamA-like transporter family TMEM40 PF15817.5 PIK37877.1 - 2.2 8.1 6.3 0.83 9.4 1.4 2.7 2 0 0 2 2 2 0 Transmembrane protein 40 family TPT PF03151.16 PIK37877.1 - 3.5 6.9 27.9 0.023 14.1 9.1 2.3 2 1 0 2 2 2 0 Triose-phosphate Transporter family Hormone_recep PF00104.30 PIK37878.1 - 1.6e-40 138.9 0.0 2.8e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 PIK37878.1 - 1.6e-29 102.1 20.3 1.8e-29 102.0 19.2 1.6 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) FAD-oxidase_C PF02913.19 PIK37879.1 - 2.3e-63 214.1 0.0 3.2e-63 213.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 PIK37879.1 - 8.6e-36 122.7 0.3 1.5e-35 122.0 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain ATHILA PF03078.15 PIK37879.1 - 0.069 11.9 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family Ribosomal_L14e PF01929.17 PIK37880.1 - 1.4e-30 105.6 9.3 2.4e-30 104.9 9.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 PIK37880.1 - 0.0024 17.8 0.3 0.0043 17.0 0.3 1.4 1 0 0 1 1 1 1 KOW motif DRY_EERY PF09750.9 PIK37880.1 - 0.027 14.7 0.4 0.035 14.4 0.4 1.3 1 0 0 1 1 1 0 Alternative splicing regulator TilS_C PF11734.8 PIK37880.1 - 0.073 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 TilS substrate C-terminal domain DREV PF05219.12 PIK37881.1 - 7.2e-89 297.4 0.0 8.8e-89 297.1 0.0 1.1 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 PIK37881.1 - 1.7e-10 40.9 0.0 3.4e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK37881.1 - 2.4e-08 34.5 0.0 7.9e-08 32.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK37881.1 - 1.8e-07 31.8 0.0 1e-06 29.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK37881.1 - 3.4e-07 30.9 0.0 1.2e-05 25.9 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK37881.1 - 0.00032 20.5 1.0 0.01 15.7 0.4 2.5 2 1 0 2 2 2 1 Methyltransferase domain Sld5 PF05916.11 PIK37882.1 - 7.4e-21 74.7 0.5 1.1e-20 74.1 0.5 1.2 1 0 0 1 1 1 1 GINS complex protein HLH PF00010.26 PIK37883.1 - 6.6e-13 48.4 1.4 1.2e-12 47.6 1.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 PIK37883.1 - 7.6e-06 26.0 0.3 1.8e-05 24.8 0.3 1.7 1 0 0 1 1 1 1 Hairy Orange adh_short PF00106.25 PIK37884.1 - 8.5e-43 146.1 0.1 1.1e-42 145.7 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK37884.1 - 8.9e-36 123.6 0.0 1.2e-35 123.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK37884.1 - 4.1e-08 33.4 0.1 5.2e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 PIK37884.1 - 0.049 13.0 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 PIK37884.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pkinase_Tyr PF07714.17 PIK37885.1 - 2.9e-70 236.5 0.0 3.4e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37885.1 - 3e-39 135.0 0.0 3.8e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.28 PIK37885.1 - 2.5e-06 27.0 0.0 4.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK37885.1 - 3.4e-06 26.6 0.0 1.1e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 PIK37885.1 - 2.7e-05 23.9 0.0 4.5e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.14 PIK37885.1 - 0.00076 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK37885.1 - 0.05 12.4 0.5 0.094 11.5 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase GRP PF07172.11 PIK37886.1 - 0.12 13.0 4.5 0.2 12.3 4.5 1.5 1 1 0 1 1 1 0 Glycine rich protein family MAJIN PF15077.6 PIK37886.1 - 6 6.6 8.8 6.9 6.4 8.8 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Pex14_N PF04695.13 PIK37886.1 - 9.2 6.9 10.5 11 6.6 10.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TPR_12 PF13424.6 PIK37887.1 - 7.2e-17 61.5 12.4 1e-06 28.9 1.7 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK37887.1 - 4.4e-11 42.1 14.8 0.03 14.1 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 PIK37887.1 - 1e-10 41.1 6.4 0.0031 17.3 0.2 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK37887.1 - 4.9e-09 35.6 16.5 0.018 15.1 0.4 6.2 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK37887.1 - 1.3e-05 25.0 17.9 1.5 9.2 0.6 7.0 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK37887.1 - 0.00019 21.2 6.0 16 5.8 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK37887.1 - 0.078 12.7 6.7 20 5.0 0.3 4.8 4 0 0 4 4 4 0 TPR repeat TPR_6 PF13174.6 PIK37887.1 - 0.095 13.4 6.3 47 4.9 0.1 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK37887.1 - 0.39 11.0 5.7 2.6 8.4 0.9 3.3 3 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 PIK37887.1 - 1.4 9.0 6.2 6.2 6.9 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat NB-ARC PF00931.22 PIK37888.1 - 7.2e-06 25.4 0.0 1.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 PIK37888.1 - 2.3e-05 24.8 0.2 0.00075 19.9 0.0 2.9 2 2 1 3 3 3 1 AAA ATPase domain NACHT PF05729.12 PIK37888.1 - 6.8e-05 22.8 1.0 0.00024 21.1 1.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK37888.1 - 0.00019 21.7 0.9 0.001 19.3 0.6 2.3 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 PIK37888.1 - 0.00019 20.9 0.0 0.00034 20.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA PF00004.29 PIK37888.1 - 0.0026 18.2 0.0 0.013 16.0 0.0 2.1 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) DED PF01335.21 PIK37888.1 - 0.0032 17.7 0.0 0.012 15.9 0.0 2.1 1 0 0 1 1 1 1 Death effector domain ATPase_2 PF01637.18 PIK37888.1 - 0.0067 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 PIK37888.1 - 0.05 13.4 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein EamA PF00892.20 PIK37889.1 - 1.5e-20 73.8 33.5 5.6e-16 59.0 9.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family EamA PF00892.20 PIK37890.1 - 5.9e-19 68.6 32.0 6.6e-13 49.0 9.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF5392 PF17370.2 PIK37890.1 - 0.006 16.7 0.1 0.02 15.0 0.1 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5392) TspO_MBR PF03073.15 PIK37890.1 - 0.0064 16.6 6.4 0.0064 16.6 6.4 2.7 2 2 0 2 2 2 1 TspO/MBR family DUF1129 PF06570.11 PIK37890.1 - 8.2 5.9 8.6 0.76 9.2 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) zf-H2C2_2 PF13465.6 PIK37891.1 - 5.7e-99 320.5 133.3 1.5e-10 41.0 2.9 14.2 14 0 0 14 14 14 14 Zinc-finger double domain zf-C2H2 PF00096.26 PIK37891.1 - 1.5e-56 185.8 120.7 7e-06 26.2 4.2 13.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK37891.1 - 1.1e-37 125.4 110.3 0.0017 19.0 2.8 13.1 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK37891.1 - 4.1e-21 74.8 88.6 0.0092 16.3 0.7 12.3 12 0 0 12 12 12 10 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK37891.1 - 9.2e-19 66.9 139.7 3.3e-05 23.5 3.8 14.7 13 4 0 13 13 13 7 C2H2-type zinc-finger domain PyrI_C PF02748.15 PIK37891.1 - 1.2e-14 53.9 71.0 0.22 11.5 0.3 12.3 12 0 0 12 12 12 11 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 PIK37891.1 - 1.1e-06 28.6 74.6 2.3 8.3 0.1 12.3 12 0 0 12 12 12 7 Zinc-finger domain C1_1 PF00130.22 PIK37891.1 - 1.6e-05 24.7 66.4 1.2 9.1 1.6 10.9 1 1 11 12 12 12 4 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2HE PF16278.5 PIK37891.1 - 3.7e-05 24.1 82.7 0.9 10.0 2.0 12.2 2 2 8 11 11 11 5 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.11 PIK37891.1 - 0.0013 18.5 21.0 2.8 7.8 0.2 7.1 4 2 3 8 8 8 2 GAGA factor DUF5616 PF18481.1 PIK37891.1 - 0.0024 18.2 0.0 76 3.6 0.0 5.3 5 2 2 7 7 7 0 Domain of unknown function (DUF5616) DUF2644 PF10841.8 PIK37891.1 - 0.039 14.2 0.0 1.3e+02 2.9 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2644) zinc_ribbon_9 PF14369.6 PIK37891.1 - 0.13 12.5 45.4 3.1 8.1 0.0 10.9 10 2 2 12 12 12 0 zinc-ribbon Baculo_IE-1 PF05290.11 PIK37891.1 - 3.3 7.6 52.2 2.1 8.3 0.1 10.7 1 1 11 12 12 12 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_11 PF16622.5 PIK37891.1 - 8 6.3 55.0 4.7 7.1 0.4 11.3 12 0 0 12 12 12 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 PIK37892.1 - 7.7e-57 187.3 60.1 6.8e-10 38.9 2.6 9.4 9 1 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK37892.1 - 1.9e-32 109.9 54.3 2.1e-07 31.0 0.8 8.2 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK37892.1 - 3.9e-23 80.1 51.5 6.8e-05 23.4 0.6 8.1 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK37892.1 - 3.3e-12 45.9 18.5 0.014 15.2 0.1 7.0 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK37892.1 - 4.6e-12 45.9 36.5 0.024 14.9 0.7 8.3 8 1 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK37892.1 - 2.8e-06 27.2 41.7 0.022 14.8 1.5 7.5 7 0 0 7 7 7 4 C2H2-type zinc finger PyrI_C PF02748.15 PIK37892.1 - 6.8e-06 25.9 25.8 0.19 11.7 0.3 6.9 7 0 0 7 7 7 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.6 PIK37892.1 - 7.4e-05 22.5 28.6 0.37 10.7 0.4 7.5 8 0 0 8 8 8 3 zinc-finger of a C2HC-type GAGA PF09237.11 PIK37892.1 - 7.5e-05 22.5 13.1 0.27 11.1 0.1 5.5 2 2 5 7 7 7 2 GAGA factor zf-met PF12874.7 PIK37892.1 - 0.00031 21.0 38.1 0.6 10.6 0.1 8.1 7 1 2 9 9 9 2 Zinc-finger of C2H2 type C1_4 PF07975.12 PIK37892.1 - 0.00064 19.9 28.9 0.3 11.3 2.7 5.2 2 2 4 6 6 6 5 TFIIH C1-like domain BolA PF01722.18 PIK37892.1 - 0.0089 16.3 4.1 1.8 8.9 0.2 4.2 3 2 1 4 4 4 1 BolA-like protein zf-H2C2_5 PF13909.6 PIK37892.1 - 0.028 14.2 0.8 0.028 14.2 0.8 8.8 9 3 0 9 9 7 0 C2H2-type zinc-finger domain DUF3268 PF11672.8 PIK37892.1 - 0.045 14.1 1.2 0.045 14.1 1.2 4.0 3 1 1 4 4 4 0 zinc-finger-containing domain Zf_RING PF16744.5 PIK37892.1 - 0.058 13.5 26.7 4.6 7.4 0.2 6.8 2 2 5 7 7 7 0 KIAA1045 RING finger zf-BED PF02892.15 PIK37892.1 - 0.12 12.4 0.5 0.12 12.4 0.5 7.0 2 2 5 7 7 7 0 BED zinc finger zinc_ribbon_15 PF17032.5 PIK37892.1 - 0.12 13.1 25.7 0.66 10.8 1.1 4.1 1 1 4 6 6 6 0 zinc-ribbon family zf-Di19 PF05605.12 PIK37892.1 - 0.15 12.4 28.9 0.34 11.2 4.1 4.7 2 2 3 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 PIK37892.1 - 0.2 11.3 17.9 5.7 6.6 0.2 6.3 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger FYVE PF01363.21 PIK37892.1 - 0.32 11.2 35.3 0.21 11.8 7.3 5.5 1 1 4 5 5 5 0 FYVE zinc finger PHF5 PF03660.14 PIK37892.1 - 0.37 11.0 15.1 3.4 7.9 1.7 4.0 2 1 3 5 5 5 0 PHF5-like protein zf-AN1 PF01428.16 PIK37892.1 - 0.5 10.6 27.3 6.3 7.0 0.1 6.9 7 0 0 7 7 7 0 AN1-like Zinc finger XPA_N PF01286.18 PIK37892.1 - 0.67 10.0 20.6 18 5.5 0.1 7.0 8 0 0 8 8 8 0 XPA protein N-terminal zf-CHCC PF10276.9 PIK37892.1 - 2.9 8.0 35.1 5.7 7.1 1.1 6.6 7 0 0 7 7 7 0 Zinc-finger domain Scramblase PF03803.15 PIK37892.1 - 7.2 5.8 5.5 29 3.9 0.4 2.6 1 1 2 3 3 3 0 Scramblase Sprouty PF05210.13 PIK37892.1 - 7.6 7.0 19.0 2.7 8.4 2.8 3.2 2 1 0 3 3 3 0 Sprouty protein (Spry) Cas1_AcylT PF07779.12 PIK37894.1 - 1.5e-135 452.8 17.5 1.3e-98 331.0 14.9 2.1 2 0 0 2 2 2 2 10 TM Acyl Transferase domain found in Cas1p DNA_ligase_A_M PF01068.21 PIK37895.1 - 2.4e-43 148.2 0.0 1.1e-42 146.0 0.0 2.1 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 PIK37895.1 - 4.1e-21 76.1 0.1 8.6e-21 75.0 0.1 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_IV PF11411.8 PIK37895.1 - 4.5e-14 52.3 0.9 8.5e-14 51.4 0.9 1.5 1 0 0 1 1 1 1 DNA ligase IV RNA_ligase PF09414.10 PIK37895.1 - 7.3e-10 39.4 0.0 2.5e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 RNA ligase BRCT_2 PF16589.5 PIK37895.1 - 5.2e-09 36.4 0.0 6.8e-05 23.2 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 PIK37895.1 - 8.4e-08 32.7 0.0 2.4e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 PIK37895.1 - 7.7e-06 26.2 0.0 0.00012 22.4 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 PIK37895.1 - 0.018 15.3 0.0 0.27 11.6 0.0 2.5 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain DUF5113 PF17140.4 PIK37895.1 - 0.053 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) DNA_ligase_A_N PF04675.14 PIK37896.1 - 2e-09 38.0 0.0 2.5e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 DNA ligase N terminus CENP-L PF13092.6 PIK37896.1 - 0.046 13.9 0.0 0.057 13.6 0.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 LRR_8 PF13855.6 PIK37897.1 - 1.3e-59 197.8 114.8 3.6e-14 52.3 5.9 9.2 3 2 8 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 PIK37897.1 - 2.3e-20 72.3 74.9 7.2e-07 29.4 2.1 10.5 5 4 4 11 11 11 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK37897.1 - 6.9e-20 71.3 26.7 1.2e-08 35.0 4.6 5.2 6 1 1 7 7 7 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK37897.1 - 2.7e-12 46.5 28.1 1.2e-05 24.9 1.6 5.2 3 1 2 5 5 5 5 Leucine-rich repeat Glycophorin_A PF01102.18 PIK37897.1 - 0.00078 19.7 0.4 0.0024 18.1 0.1 1.9 2 0 0 2 2 2 1 Glycophorin A LRRCT PF01463.24 PIK37897.1 - 0.027 15.0 0.0 0.087 13.4 0.0 2.0 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain TMEM154 PF15102.6 PIK37897.1 - 0.045 13.6 1.4 0.12 12.2 1.4 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF1180 PF06679.12 PIK37897.1 - 0.059 13.8 0.2 0.097 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) LRR_1 PF00560.33 PIK37897.1 - 0.07 13.7 50.4 5.2 8.0 0.4 12.6 11 2 1 12 12 12 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK37897.1 - 2.5 8.4 40.2 1.8 8.8 0.2 8.9 9 0 0 9 9 9 0 Leucine Rich repeat APH PF01636.23 PIK37898.1 - 3e-44 151.7 0.0 4.3e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 PIK37898.1 - 8.1e-08 31.9 0.0 3.1e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 PIK37898.1 - 2.8e-05 23.8 0.0 5.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Acyl-CoA_dh_N PF02771.16 PIK37898.1 - 5.3e-05 23.8 0.0 0.00012 22.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain RIO1 PF01163.22 PIK37898.1 - 0.0046 16.6 0.0 0.35 10.4 0.0 2.3 2 0 0 2 2 2 1 RIO1 family DUF1679 PF07914.11 PIK37898.1 - 0.029 13.3 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 PIK37898.1 - 0.049 13.0 0.0 0.94 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein kinase domain UPF0126 PF03458.13 PIK37898.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 UPF0126 domain Epimerase PF01370.21 PIK37899.1 - 6.3e-23 81.5 0.0 7.6e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK37899.1 - 9e-21 74.1 0.0 1.4e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK37899.1 - 1.8e-13 50.8 0.0 3e-13 50.1 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 PIK37899.1 - 1.3e-12 47.5 0.0 3.8e-12 45.9 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 PIK37899.1 - 6.7e-12 45.5 0.0 1.3e-11 44.5 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 PIK37899.1 - 2.2e-08 34.0 0.0 3.1e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 PIK37899.1 - 8.4e-06 25.8 0.0 5.4e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK37899.1 - 0.00012 21.4 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 PIK37899.1 - 0.0004 19.9 0.0 0.0013 18.2 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK37899.1 - 0.013 14.7 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Rhomboid PF01694.22 PIK37900.1 - 1.3e-23 83.7 12.2 2.3e-23 82.9 12.2 1.4 1 0 0 1 1 1 1 Rhomboid family IFT81_CH PF18383.1 PIK37901.1 - 3.9e-49 166.0 0.9 3.9e-49 166.0 0.9 3.5 4 1 0 4 4 4 1 Intraflagellar transport 81 calponin homology domain PI3K_P85_iSH2 PF16454.5 PIK37901.1 - 0.0014 18.3 2.4 0.0014 18.3 2.4 5.9 1 1 4 5 5 5 2 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Spc7 PF08317.11 PIK37901.1 - 0.0054 15.7 13.1 0.0054 15.7 13.1 4.4 1 1 4 5 5 5 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 PIK37901.1 - 0.9 9.6 66.9 0.023 14.7 5.1 5.4 4 2 1 5 5 5 0 TPR/MLP1/MLP2-like protein MtrG PF04210.13 PIK37901.1 - 1.1 9.2 5.8 0.95 9.4 0.0 3.5 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Uteroglobin PF01099.17 PIK37901.1 - 1.5 9.2 7.3 5.3 7.4 0.1 3.8 3 0 0 3 3 3 0 Uteroglobin family MS_channel PF00924.18 PIK37901.1 - 1.6 8.2 3.9 5.9 6.4 0.2 2.6 2 0 0 2 2 2 0 Mechanosensitive ion channel Golgin_A5 PF09787.9 PIK37901.1 - 2.8 7.3 70.0 0.018 14.5 12.7 4.0 1 1 2 4 4 4 0 Golgin subfamily A member 5 GAS PF13851.6 PIK37901.1 - 4.4 6.6 73.8 0.33 10.3 27.4 5.0 3 3 1 4 4 4 0 Growth-arrest specific micro-tubule binding NPBW PF15180.6 PIK37901.1 - 7.4 6.5 8.3 3 7.7 0.2 3.5 3 0 0 3 3 3 0 Neuropeptides B and W DNA_photolyase PF00875.18 PIK37902.1 - 2.9e-28 98.9 0.0 5.1e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase MsyB PF13984.6 PIK37903.1 - 0.0093 16.3 0.3 0.012 15.9 0.3 1.3 1 0 0 1 1 1 1 MsyB protein Phage_Coat_A PF05357.13 PIK37904.1 - 0.044 13.6 0.3 1.5 8.6 0.1 2.2 2 0 0 2 2 2 0 Phage Coat Protein A MMgT PF10270.9 PIK37905.1 - 5.1e-16 58.8 0.0 6.1e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter DUF2087 PF09860.9 PIK37906.1 - 0.12 12.5 1.9 52 4.1 0.1 3.6 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2087) Med26 PF08711.11 PIK37907.1 - 1.6e-10 40.9 0.0 5.2e-10 39.2 0.0 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain TMEM51 PF15345.6 PIK37908.1 - 0.00069 19.5 0.1 0.00076 19.4 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 EphA2_TM PF14575.6 PIK37908.1 - 0.0019 19.1 0.1 0.0036 18.1 0.1 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain OSTbeta PF15048.6 PIK37908.1 - 0.0019 18.3 0.1 0.0027 17.8 0.1 1.3 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein FAM176 PF14851.6 PIK37908.1 - 0.0022 17.7 1.2 0.0033 17.1 1.2 1.5 1 1 0 1 1 1 1 FAM176 family Shisa PF13908.6 PIK37908.1 - 0.0062 16.8 0.4 0.008 16.4 0.4 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Protocadherin PF08374.11 PIK37908.1 - 0.0088 16.0 0.1 0.01 15.8 0.1 1.1 1 0 0 1 1 1 1 Protocadherin FHIPEP PF00771.20 PIK37908.1 - 0.012 14.1 0.0 0.015 13.8 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family DUF4834 PF16118.5 PIK37908.1 - 0.015 16.2 0.0 0.024 15.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Tmemb_9 PF05434.11 PIK37908.1 - 0.021 14.7 0.3 0.032 14.1 0.2 1.4 1 1 0 1 1 1 0 TMEM9 UPF0542 PF15086.6 PIK37908.1 - 0.03 14.2 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Baculo_11_kDa PF06143.11 PIK37908.1 - 0.036 13.6 1.0 0.07 12.7 1.0 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM154 PF15102.6 PIK37908.1 - 0.042 13.8 3.5 0.08 12.9 3.5 1.6 1 1 0 1 1 1 0 TMEM154 protein family DUF2207 PF09972.9 PIK37908.1 - 0.043 12.6 0.0 0.048 12.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4576 PF15144.6 PIK37908.1 - 0.062 13.2 0.5 0.12 12.3 0.3 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4576) 7TM_GPCR_Srv PF10323.9 PIK37908.1 - 0.066 12.6 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF2561 PF10812.8 PIK37908.1 - 0.11 12.6 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Glycophorin_A PF01102.18 PIK37908.1 - 0.2 11.9 1.9 0.28 11.4 0.8 1.7 1 1 1 2 2 2 0 Glycophorin A OAD_gamma PF04277.13 PIK37908.1 - 0.24 12.0 1.4 0.47 11.1 1.4 1.6 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ig_2 PF13895.6 PIK37909.1 - 8.6e-05 22.8 0.1 0.00028 21.1 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK37909.1 - 0.0019 18.7 0.1 0.005 17.4 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain RE_SinI PF09570.10 PIK37909.1 - 0.044 13.0 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 SinI restriction endonuclease DUF2207 PF09972.9 PIK37909.1 - 0.09 11.5 0.0 0.097 11.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4448 PF14610.6 PIK37909.1 - 0.092 12.5 0.0 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) MPS-4 PF17523.2 PIK37909.1 - 0.14 12.3 1.2 0.47 10.6 0.3 2.2 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 MRAP PF15183.6 PIK37909.1 - 0.33 10.9 1.3 0.61 10.1 1.3 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Syndecan PF01034.20 PIK37909.1 - 0.45 10.5 2.2 1.3 9.0 2.2 1.7 1 0 0 1 1 1 0 Syndecan domain Ig_2 PF13895.6 PIK37910.1 - 5.9e-05 23.3 1.4 0.00011 22.5 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK37910.1 - 0.00064 20.3 1.5 0.0013 19.3 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain SID-1_RNA_chan PF13965.6 PIK37910.1 - 0.0092 14.5 2.0 0.013 13.9 2.0 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 TMEM154 PF15102.6 PIK37910.1 - 0.0096 15.8 2.5 0.016 15.1 2.5 1.3 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 PIK37910.1 - 0.069 14.0 0.0 0.16 12.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ig PF00047.25 PIK37910.1 - 0.2 11.9 4.2 0.22 11.7 1.0 2.7 2 1 0 2 2 2 0 Immunoglobulin domain DUF4834 PF16118.5 PIK37910.1 - 0.22 12.5 1.6 0.61 11.1 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Ig_2 PF13895.6 PIK37911.1 - 2.9e-05 24.3 0.8 0.00012 22.3 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK37911.1 - 0.004 17.7 0.1 0.004 17.7 0.1 2.9 3 0 0 3 3 3 1 Immunoglobulin domain Stevor PF17410.2 PIK37911.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame SID-1_RNA_chan PF13965.6 PIK37911.1 - 0.019 13.4 0.6 0.027 12.9 0.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HemY_N PF07219.13 PIK37911.1 - 0.05 13.8 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 HemY protein N-terminus Phage_holin_2_4 PF16082.5 PIK37911.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like ig PF00047.25 PIK37911.1 - 4.8 7.4 7.3 0.52 10.5 0.6 2.8 3 1 0 3 3 3 0 Immunoglobulin domain WD40 PF00400.32 PIK37913.1 - 1.3e-19 70.1 13.1 0.0033 18.2 0.2 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK37913.1 - 9.5e-14 51.5 0.8 0.051 13.9 0.0 5.5 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK37913.1 - 1.8e-05 23.9 0.2 0.048 12.6 0.0 2.9 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK37913.1 - 5.1e-05 23.3 0.1 0.003 17.4 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 PIK37913.1 - 0.0042 17.0 3.3 11 6.2 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 PIK37913.1 - 0.13 10.2 0.1 5.1 5.0 0.1 2.4 2 1 0 2 2 2 0 IKI3 family APC_u5 PF16630.5 PIK37914.1 - 0.11 13.6 1.1 0.23 12.5 0.2 2.0 2 0 0 2 2 2 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs PP2C PF00481.21 PIK37915.1 - 2.4e-33 115.8 0.0 2.7e-33 115.7 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C DUF4488 PF14869.6 PIK37915.1 - 0.071 13.0 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) Kelch_4 PF13418.6 PIK37916.1 - 0.072 13.1 0.1 7.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Glyoxalase_2 PF12681.7 PIK37916.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Glyoxalase-like domain Kelch_1 PF01344.25 PIK37916.1 - 0.25 10.9 1.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Kelch motif DUF4218 PF13960.6 PIK37917.1 - 2.7e-05 23.8 0.0 8.7e-05 22.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) WIF PF02019.18 PIK37917.1 - 0.042 13.5 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 WIF domain zf-C3HC4_3 PF13920.6 PIK37917.1 - 9.1 6.2 6.9 0.98 9.3 1.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Death PF00531.22 PIK37919.1 - 2.3e-12 46.9 1.3 3.1e-12 46.5 1.3 1.2 1 0 0 1 1 1 1 Death domain CARD_2 PF16739.5 PIK37919.1 - 0.027 14.4 0.8 0.05 13.6 0.8 1.4 1 0 0 1 1 1 0 Caspase recruitment domain rve PF00665.26 PIK37920.1 - 2.6e-20 72.8 0.0 4.2e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK37920.1 - 2.6e-05 23.9 0.1 6.6e-05 22.6 0.1 1.7 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK37921.1 - 4.1e-30 104.9 0.0 6.4e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK37921.1 - 8.4e-05 23.1 0.2 0.0022 18.5 0.2 2.6 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK37921.1 - 0.11 12.9 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK37921.1 - 0.11 13.1 0.0 0.36 11.5 0.0 1.9 1 1 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.27 PIK37922.1 - 8.3e-35 120.3 0.4 2.8e-34 118.6 0.2 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK37922.1 - 2.5e-06 27.3 1.8 0.0013 18.6 1.8 2.8 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Ig_3 PF13927.6 PIK37923.1 - 9.6e-13 48.5 0.0 6.7e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK37923.1 - 4.1e-07 30.2 0.0 0.0068 16.7 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ldl_recept_a PF00057.18 PIK37923.1 - 4.5e-06 26.8 2.2 1.3e-05 25.3 2.2 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A I-set PF07679.16 PIK37923.1 - 0.00062 19.8 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK37923.1 - 0.0047 17.0 0.2 0.039 14.0 0.2 2.5 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK37923.1 - 0.043 13.4 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 PIK37923.1 - 0.14 12.4 0.1 1.5 9.0 0.0 2.6 2 1 1 3 3 3 0 Immunoglobulin domain 7tm_2 PF00002.24 PIK37924.1 - 1.5e-28 99.7 22.4 2.3e-28 99.2 22.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK37924.1 - 5.3e-16 58.9 0.5 9.8e-16 58.0 0.5 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK37924.1 - 6.9e-08 32.0 14.5 1.1e-07 31.4 14.5 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor GAIN PF16489.5 PIK37924.1 - 0.0065 15.9 1.3 0.013 14.9 0.3 1.9 2 0 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain Pkinase_Tyr PF07714.17 PIK37925.1 - 7.4e-12 45.1 0.1 1.7e-10 40.6 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK37925.1 - 1.1e-08 34.7 0.1 2.6e-08 33.6 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain C2-set_2 PF08205.12 PIK37925.1 - 4.4e-06 26.7 1.3 1.8e-05 24.7 0.8 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK37925.1 - 0.036 14.7 0.7 0.11 13.1 0.7 1.9 1 0 0 1 1 1 0 Immunoglobulin domain E1-E2_ATPase PF00122.20 PIK37925.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 E1-E2 ATPase Hum_adeno_E3A PF05393.11 PIK37926.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein IMUP PF15761.5 PIK37926.1 - 0.84 10.3 8.3 0.31 11.8 4.7 2.0 2 0 0 2 2 2 0 Immortalisation up-regulated protein Formyl_trans_N PF00551.19 PIK37927.1 - 5.3e-10 39.3 0.0 1.2e-09 38.1 0.0 1.5 1 1 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 PIK37927.1 - 2.5e-05 24.5 0.0 5.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain ECH_1 PF00378.20 PIK37928.1 - 2.6e-24 85.9 0.1 9.1e-24 84.1 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Formyl_trans_C PF02911.18 PIK37928.1 - 1.4e-14 54.1 0.0 2.9e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Formyl_trans_N PF00551.19 PIK37928.1 - 1.9e-09 37.5 0.0 4e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase ECH_2 PF16113.5 PIK37928.1 - 0.00052 19.6 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Iso_dh PF00180.20 PIK37929.1 - 4.6e-68 229.9 0.1 5.4e-68 229.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Fibrinogen_C PF00147.18 PIK37930.1 - 1.7e-81 273.2 6.9 2e-81 273.0 6.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Sulfate_transp PF00916.20 PIK37931.1 - 6.2e-64 216.1 4.7 2.7e-61 207.4 1.5 2.2 1 1 0 2 2 2 2 Sulfate permease family STAS PF01740.21 PIK37931.1 - 4e-25 87.7 0.5 1.5e-24 85.9 0.5 1.9 1 1 0 1 1 1 1 STAS domain STAS_2 PF13466.6 PIK37931.1 - 0.073 13.4 0.1 0.15 12.4 0.1 1.5 1 0 0 1 1 1 0 STAS domain FMO-like PF00743.19 PIK37932.1 - 1.1e-46 159.4 0.0 1.3e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK37932.1 - 5.4e-10 39.0 2.7 1.4e-08 34.3 2.7 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK37932.1 - 5.2e-08 32.5 0.0 9.3e-08 31.6 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK37932.1 - 1.1e-06 28.7 0.0 2.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK37932.1 - 2.7e-06 27.2 0.1 0.0017 18.0 0.5 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 PIK37932.1 - 5.6e-06 25.8 0.1 1.8e-05 24.1 0.1 1.7 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 PIK37932.1 - 0.00022 20.5 0.0 0.0015 17.8 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 PIK37932.1 - 0.0039 17.2 0.1 0.066 13.2 0.1 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 PIK37932.1 - 0.0066 15.8 0.0 0.018 14.3 0.0 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 PIK37932.1 - 0.024 13.4 0.5 0.043 12.5 0.5 1.4 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 PIK37932.1 - 0.026 13.6 0.4 0.036 13.2 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain Mcl1_mid PF12341.8 PIK37932.1 - 0.086 12.2 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region AlaDh_PNT_C PF01262.21 PIK37932.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 PIK37932.1 - 0.3 10.3 0.7 0.59 9.3 0.7 1.4 1 0 0 1 1 1 0 FAD binding domain DUF1151 PF06625.11 PIK37933.1 - 2e-15 56.7 14.2 3.6e-15 55.9 14.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) SH3_1 PF00018.28 PIK37933.1 - 6.6e-09 35.2 0.0 1.3e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK37933.1 - 4.2e-07 29.7 0.0 7.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_1 PF00036.32 PIK37934.1 - 5.2e-24 82.0 8.9 5.9e-07 28.6 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 PIK37934.1 - 4.9e-22 78.2 8.8 1.1e-14 54.7 2.9 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK37934.1 - 3.4e-20 70.2 10.4 3.4e-06 26.5 0.1 4.9 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 PIK37934.1 - 3.9e-19 67.2 13.2 2.6e-07 29.8 0.3 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 PIK37934.1 - 4.6e-15 55.2 9.8 1.4e-07 31.2 1.2 3.7 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK37934.1 - 6.2e-07 29.7 3.6 0.041 14.2 1.4 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK37934.1 - 0.011 15.7 5.5 3.7 7.5 1.0 3.1 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 PIK37934.1 - 0.021 15.1 0.7 0.39 11.1 0.0 2.9 2 1 1 3 3 3 0 EF-hand domain Acyltransf_C PF16076.5 PIK37934.1 - 0.088 12.9 0.5 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 Acyltransferase C-terminus S10_plectin PF03501.15 PIK37934.1 - 0.099 12.7 0.0 0.25 11.4 0.0 1.7 1 1 0 1 1 1 0 Plectin/S10 domain Fer4_19 PF06902.11 PIK37934.1 - 0.17 11.9 0.0 1.5 9.0 0.0 2.5 4 0 0 4 4 4 0 Divergent 4Fe-4S mono-cluster GGACT PF06094.12 PIK37935.1 - 0.017 15.7 0.0 0.019 15.6 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like Pkinase PF00069.25 PIK37940.1 - 2.4e-51 174.6 0.0 1.1e-50 172.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37940.1 - 2.5e-23 82.7 0.0 3.7e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK37940.1 - 0.0082 15.5 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK37940.1 - 0.0099 15.8 0.0 0.042 13.8 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK37940.1 - 0.023 13.7 0.2 0.038 13.0 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 PIK37940.1 - 0.043 13.4 0.4 0.34 10.5 0.1 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 PIK37940.1 - 0.048 13.3 0.1 0.097 12.3 0.1 1.6 1 0 0 1 1 1 0 RIO1 family DSPc PF00782.20 PIK37941.1 - 1.4e-12 47.6 0.0 1.8e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK37941.1 - 8.1e-06 25.6 0.0 8.8e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK37941.1 - 9.4e-06 25.8 0.0 1.2e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK37941.1 - 0.0054 16.3 0.0 0.012 15.2 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 PIK37941.1 - 0.011 15.7 0.0 0.042 13.8 0.0 1.8 1 1 0 1 1 1 0 Tyrosine phosphatase family Spectrin PF00435.21 PIK37942.1 - 1.3e-74 247.4 60.9 1.6e-16 60.7 1.4 8.4 8 0 0 8 8 8 7 Spectrin repeat GAS2 PF02187.17 PIK37942.1 - 4.1e-32 110.1 0.9 1.2e-31 108.6 0.9 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_6 PF13405.6 PIK37942.1 - 2e-05 24.1 2.0 0.00091 19.0 1.0 3.2 2 0 0 2 2 2 1 EF-hand domain DUF3134 PF11332.8 PIK37942.1 - 5.8e-05 23.3 0.4 0.04 14.2 0.0 3.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3134) EF-hand_7 PF13499.6 PIK37942.1 - 0.00014 22.2 2.4 0.00042 20.7 0.4 3.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK37942.1 - 0.0014 18.0 2.1 0.0032 16.9 0.9 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 PIK37942.1 - 0.0015 18.0 0.9 0.0047 16.4 0.9 1.9 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 PIK37942.1 - 0.0058 16.4 0.7 0.11 12.3 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain pair Spore_III_AB PF09548.10 PIK37942.1 - 0.019 15.1 0.4 0.019 15.1 0.4 3.4 2 2 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Cauli_DNA-bind PF03310.13 PIK37942.1 - 0.13 12.4 3.0 6.3 6.9 0.0 3.9 2 1 1 3 3 3 0 Caulimovirus DNA-binding protein DUF2852 PF11014.8 PIK37942.1 - 0.19 11.9 6.7 0.14 12.3 2.7 3.0 2 0 0 2 2 1 0 Protein of unknown function (DUF2852) T3SS_needle_E PF08988.10 PIK37942.1 - 0.44 10.7 9.4 13 6.1 0.0 4.9 4 1 0 4 4 4 0 Type III secretion system, cytoplasmic E component of needle ANAPC4 PF12896.7 PIK37942.1 - 0.71 9.3 15.1 1.7 8.1 0.5 4.9 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 4 DUF2018 PF09442.10 PIK37942.1 - 1.4 9.9 9.9 0.4 11.7 0.3 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF2018) DUF948 PF06103.11 PIK37942.1 - 3.5 8.0 18.9 22 5.4 0.1 7.3 7 1 1 8 8 6 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 PIK37943.1 - 2.4e-73 243.3 54.4 1.1e-16 61.2 2.9 9.1 8 1 1 9 9 9 8 Spectrin repeat PilJ PF13675.6 PIK37943.1 - 6.9e-06 26.1 41.7 0.22 11.6 1.1 9.2 5 3 3 10 10 10 4 Type IV pili methyl-accepting chemotaxis transducer N-term THOC7 PF05615.13 PIK37943.1 - 0.013 15.8 0.9 0.013 15.8 0.9 6.4 3 2 3 6 6 6 0 Tho complex subunit 7 Sec34 PF04136.15 PIK37943.1 - 0.21 11.5 30.7 9.8 6.1 0.8 8.2 5 2 2 8 8 8 0 Sec34-like family Zmiz1_N PF18028.1 PIK37943.1 - 0.96 9.8 4.0 7.7 6.9 0.0 4.1 4 0 0 4 4 4 0 Zmiz1 N-terminal tetratricopeptide repeat domain DASH_Duo1 PF08651.10 PIK37943.1 - 1.3 8.9 7.8 1.8 8.4 0.1 5.0 5 0 0 5 5 5 0 DASH complex subunit Duo1 GAT PF03127.14 PIK37943.1 - 2.7 8.4 7.1 10 6.5 0.3 4.7 4 1 0 4 4 4 0 GAT domain Cep57_MT_bd PF06657.13 PIK37943.1 - 4.6 7.8 28.3 1.8 9.1 2.6 7.8 7 1 1 8 8 8 0 Centrosome microtubule-binding domain of Cep57 FUSC-like PF12805.7 PIK37943.1 - 5.3 6.0 7.1 2.8 6.9 0.7 2.8 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS PI_PP_I PF18363.1 PIK37943.1 - 8.1 6.7 17.4 0.56 10.4 0.8 5.6 6 0 0 6 6 6 0 Phosphoinositide phosphatase insertion domain Spectrin PF00435.21 PIK37944.1 - 1.9e-65 218.0 89.0 2.3e-08 34.4 0.3 14.8 13 2 2 15 15 15 13 Spectrin repeat Activator-TraM PF11657.8 PIK37944.1 - 0.0018 18.2 1.2 0.0018 18.2 1.2 3.6 4 0 0 4 4 4 1 Transcriptional activator TraM Baculo_p24 PF05073.12 PIK37944.1 - 0.0067 16.2 2.1 0.0067 16.2 2.1 7.4 5 2 4 10 10 10 2 Baculovirus P24 capsid protein KMP11 PF03037.16 PIK37944.1 - 0.071 13.9 0.4 0.071 13.9 0.4 5.5 5 0 0 5 5 5 0 Kinetoplastid membrane protein 11 Mce4_CUP1 PF11887.8 PIK37944.1 - 0.26 10.7 12.0 0.59 9.5 0.1 4.6 5 0 0 5 5 5 0 Cholesterol uptake porter CUP1 of Mce4, putative Spc7 PF08317.11 PIK37944.1 - 0.72 8.7 91.2 0.095 11.6 6.0 9.7 2 2 6 10 10 10 0 Spc7 kinetochore protein FAA_hydro_N_2 PF18288.1 PIK37944.1 - 1.1 9.7 13.1 3.7 8.0 0.1 5.3 4 0 0 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 MatP_C PF17414.2 PIK37944.1 - 1.7 8.9 12.3 0.12 12.5 3.4 4.1 3 0 0 3 3 3 0 MatP C-terminal ribbon-helix-helix domain Fic PF02661.18 PIK37944.1 - 4.2 8.3 18.4 0.68 10.9 0.0 6.7 8 1 0 8 8 8 0 Fic/DOC family Spectrin PF00435.21 PIK37945.1 - 1.4e-34 118.7 52.4 2.6e-07 31.1 2.9 11.3 8 2 4 12 12 12 8 Spectrin repeat Fic PF02661.18 PIK37945.1 - 0.015 16.2 4.0 5.1 8.1 0.0 4.4 4 0 0 4 4 4 0 Fic/DOC family NPV_P10 PF05531.12 PIK37945.1 - 0.36 11.3 34.9 0.79 10.2 0.0 9.4 7 2 3 10 10 10 0 Nucleopolyhedrovirus P10 protein Bap31_Bap29_C PF18035.1 PIK37945.1 - 0.54 10.3 0.0 0.54 10.3 0.0 5.5 8 0 0 8 8 8 0 Bap31/Bap29 cytoplasmic coiled-coil domain Baculo_PEP_C PF04513.12 PIK37945.1 - 0.81 9.7 26.6 3.6 7.6 1.0 6.8 6 2 2 8 8 8 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mce4_CUP1 PF11887.8 PIK37945.1 - 3.9 6.9 7.5 28 4.0 0.1 3.8 4 0 0 4 4 4 0 Cholesterol uptake porter CUP1 of Mce4, putative Spectrin PF00435.21 PIK37946.1 - 1.3e-16 60.9 18.6 4.9e-06 27.0 0.0 5.5 4 2 1 5 5 5 3 Spectrin repeat DUF4407 PF14362.6 PIK37946.1 - 0.1 11.9 8.4 0.9 8.8 0.1 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.9 PIK37946.1 - 0.18 12.1 10.8 70 3.8 0.0 6.3 5 2 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 PIK37946.1 - 0.63 10.5 14.1 27 5.3 0.1 6.1 4 3 2 6 6 6 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 PIK37946.1 - 1.1 9.7 9.6 4.5 7.7 0.0 5.1 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) XhlA PF10779.9 PIK37946.1 - 6.9 7.0 11.6 18 5.6 0.2 5.4 6 0 0 6 6 6 0 Haemolysin XhlA Laminin_II PF06009.12 PIK37946.1 - 7.6 6.6 9.6 4.4 7.3 0.2 4.2 4 1 0 4 4 4 0 Laminin Domain II 7tm_1 PF00001.21 PIK37947.1 - 2e-23 83.1 13.3 2.4e-23 82.8 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK37947.1 - 6.8e-05 22.4 2.8 0.0001 21.8 2.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Srg PF02118.21 PIK37947.1 - 0.013 15.1 10.7 0.02 14.6 10.7 1.3 1 0 0 1 1 1 0 Srg family chemoreceptor Serpentine_r_xa PF03383.15 PIK37947.1 - 0.074 13.0 1.6 0.17 11.8 1.6 1.5 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa Ribosomal_L19e PF01280.20 PIK37948.1 - 4.1e-17 62.6 5.9 4.1e-17 62.6 5.9 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e LMBR1 PF04791.16 PIK37948.1 - 8.3 5.2 7.5 8.6 5.1 7.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RFC1 PF08519.12 PIK37949.1 - 9.6e-23 81.1 0.0 2.6e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 PIK37949.1 - 1.7e-15 57.6 0.0 6e-15 55.8 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 PIK37949.1 - 3e-12 46.7 0.2 1.5e-11 44.5 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 PIK37949.1 - 1.5e-07 31.5 0.0 9.1e-07 29.0 0.1 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain PTCB-BRCT PF12738.7 PIK37949.1 - 0.00024 21.0 0.0 0.00074 19.4 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.12 PIK37949.1 - 0.00051 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 PIK37949.1 - 0.0012 19.2 0.0 0.021 15.2 0.0 3.0 1 1 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 PIK37949.1 - 0.0022 18.5 0.3 0.015 15.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 PIK37949.1 - 0.0031 17.9 0.7 0.02 15.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 PIK37949.1 - 0.0041 17.2 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK37949.1 - 0.0049 16.4 0.1 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK37949.1 - 0.0074 16.6 0.1 0.059 13.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK37949.1 - 0.0087 16.1 0.0 0.03 14.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 PIK37949.1 - 0.024 14.8 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK37949.1 - 0.026 14.9 0.0 0.059 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 PIK37949.1 - 0.064 13.0 0.0 0.19 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 PIK37949.1 - 0.091 12.7 0.5 0.5 10.3 0.2 2.2 1 1 1 2 2 2 0 NTPase DNA_pol_A_exo1 PF01612.20 PIK37950.1 - 8.9e-05 22.3 0.0 0.00019 21.2 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S14 PF00253.21 PIK37950.1 - 0.01 15.5 0.1 0.024 14.4 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S14p/S29e SAP30_Sin3_bdg PF13867.6 PIK37950.1 - 0.041 14.2 0.1 0.12 12.7 0.1 1.8 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Lar_restr_allev PF14354.6 PIK37950.1 - 0.11 12.9 0.3 0.24 11.8 0.3 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar Fer4_17 PF13534.6 PIK37950.1 - 0.27 11.8 2.1 0.46 11.1 0.8 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain DNA_pol_A_exo1 PF01612.20 PIK37951.1 - 0.00036 20.3 0.0 0.00051 19.8 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease GATA PF00320.27 PIK37952.1 - 5.2e-30 102.8 19.1 1.7e-15 56.3 5.1 3.1 3 0 0 3 3 3 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 PIK37952.1 - 8e-06 25.3 7.1 0.016 14.7 1.3 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.10 PIK37952.1 - 0.00038 20.5 4.0 1.3 9.2 0.0 3.3 2 1 1 3 3 3 2 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.10 PIK37952.1 - 0.004 17.2 3.0 0.82 9.8 0.2 2.9 2 1 0 2 2 2 2 Zinc ribbon domain Auto_anti-p27 PF06677.12 PIK37952.1 - 0.0087 16.2 5.1 0.5 10.6 0.3 2.5 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.17 PIK37952.1 - 0.011 15.7 4.4 0.45 10.4 0.7 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 OrfB_Zn_ribbon PF07282.11 PIK37952.1 - 0.031 14.2 6.7 0.8 9.7 0.3 2.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain TDP43_N PF18694.1 PIK37952.1 - 0.081 12.8 0.4 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain ArfGap PF01412.18 PIK37952.1 - 0.15 12.1 9.4 0.8 9.8 0.1 2.8 2 1 0 2 2 2 0 Putative GTPase activating protein for Arf DZR PF12773.7 PIK37952.1 - 0.4 10.7 11.0 7.1 6.8 8.1 3.3 2 1 1 3 3 3 0 Double zinc ribbon Prim_Zn_Ribbon PF08273.12 PIK37952.1 - 0.49 10.7 10.7 0.42 10.9 3.6 2.8 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Menin PF05053.13 PIK37952.1 - 0.62 8.3 2.6 0.71 8.2 2.6 1.1 1 0 0 1 1 1 0 Menin Apocytochr_F_N PF16639.5 PIK37952.1 - 0.81 10.0 4.0 21 5.4 0.1 3.3 2 1 2 4 4 4 0 Apocytochrome F, N-terminal zf-CHY PF05495.12 PIK37952.1 - 1.3 9.6 7.2 7.2 7.2 0.4 3.1 3 0 0 3 3 3 0 CHY zinc finger Presenilin PF01080.17 PIK37952.1 - 1.5 7.5 3.3 1.8 7.2 3.3 1.1 1 0 0 1 1 1 0 Presenilin API5 PF05918.11 PIK37952.1 - 1.7 7.4 4.3 2.1 7.1 4.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Elf1 PF05129.13 PIK37952.1 - 1.9 8.6 10.9 2.2 8.4 0.4 3.4 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like Cytochrom_c3_2 PF14537.6 PIK37952.1 - 2.4 8.7 10.6 0.061 13.8 2.5 2.3 2 1 0 2 2 2 0 Cytochrome c3 zf-ribbon_3 PF13248.6 PIK37952.1 - 4.1 6.9 11.7 3.2 7.3 0.1 4.1 4 0 0 4 4 4 0 zinc-ribbon domain Vps36-NZF-N PF16988.5 PIK37952.1 - 6.2 6.3 9.9 0.31 10.5 0.2 3.2 2 2 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cytochrome_C7 PF14522.6 PIK37952.1 - 7.8 6.6 10.3 0.075 13.0 1.4 2.3 3 0 0 3 3 2 0 Cytochrome c7 and related cytochrome c SQS_PSY PF00494.19 PIK37953.1 - 6.4e-44 150.4 0.0 7.9e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Octopine_DH PF02317.17 PIK37953.1 - 0.002 18.2 0.0 0.0083 16.2 0.0 1.9 2 0 0 2 2 2 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain MEA1 PF06910.11 PIK37954.1 - 6.5e-06 26.8 1.7 1.4e-05 25.7 1.7 1.6 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Lectin_C PF00059.21 PIK37955.1 - 2.7e-71 237.2 24.4 3.4e-21 76.0 1.1 5.3 5 0 0 5 5 5 5 Lectin C-type domain UL45 PF05473.12 PIK37955.1 - 1e-08 35.1 10.8 0.023 14.3 0.1 4.7 3 1 1 4 4 4 3 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 PIK37955.1 - 0.0094 16.3 1.0 33 5.0 0.0 4.4 5 0 0 5 5 5 2 Extracellular link domain Lectin_C PF00059.21 PIK37956.1 - 1.4e-78 260.7 21.9 5.1e-22 78.6 0.5 4.1 4 0 0 4 4 4 4 Lectin C-type domain UL45 PF05473.12 PIK37956.1 - 1.1e-07 31.7 19.9 0.01 15.5 0.0 5.5 5 2 1 6 6 6 3 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 PIK37956.1 - 0.00055 20.3 0.9 5.1 7.5 0.1 3.7 3 0 0 3 3 3 1 Extracellular link domain Chordopox_A33R PF05966.12 PIK37956.1 - 0.01 15.1 1.6 1.5 8.1 0.3 2.4 2 0 0 2 2 2 0 Chordopoxvirus A33R protein Syndecan PF01034.20 PIK37956.1 - 0.025 14.5 3.4 0.054 13.4 3.4 1.4 1 0 0 1 1 1 0 Syndecan domain ECSCR PF15820.5 PIK37956.1 - 0.061 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator SBP_bac_10 PF07596.11 PIK37956.1 - 0.091 12.7 1.0 0.24 11.3 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1559) PMG PF05287.12 PIK37957.1 - 0.056 13.5 26.1 56 3.7 1.2 5.2 1 1 1 2 2 2 0 PMG protein Creatinase_N_2 PF16189.5 PIK37957.1 - 2.3 8.3 4.1 33 4.5 0.1 3.4 2 1 1 3 3 3 0 Creatinase/Prolidase N-terminal domain DUF3093 PF11292.8 PIK37957.1 - 3.7 7.8 9.2 20 5.4 0.8 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF3093) FMN_bind_2 PF04299.12 PIK37957.1 - 4.7 6.9 32.8 8 6.1 0.6 7.8 1 1 6 7 7 7 0 Putative FMN-binding domain YjbE PF11106.8 PIK37959.1 - 0.22 11.8 0.0 0.25 11.6 0.0 1.1 1 0 0 1 1 1 0 Exopolysaccharide production protein YjbE DED PF01335.21 PIK37960.1 - 7e-05 23.1 0.2 9.9e-05 22.6 0.2 1.2 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 PIK37960.1 - 0.15 12.3 0.1 0.22 11.7 0.1 1.3 1 0 0 1 1 1 0 Death domain Sds3 PF08598.11 PIK37960.1 - 0.22 11.5 0.2 2.4 8.1 0.0 2.0 2 0 0 2 2 2 0 Sds3-like RHD3 PF05879.12 PIK37961.1 - 8.1e-06 24.3 0.0 8.1e-06 24.3 0.0 3.1 4 0 0 4 4 4 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK37961.1 - 1.1e-05 25.6 0.1 1.1e-05 25.6 0.1 3.5 4 1 1 5 5 5 1 Dynamin family GBP PF02263.19 PIK37961.1 - 1.2e-05 24.8 0.0 1.2e-05 24.8 0.0 2.8 4 0 0 4 4 4 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 PIK37961.1 - 0.00083 19.4 0.0 0.0029 17.6 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 PIK37962.1 - 4.2e-09 36.0 0.1 6.5e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 PIK37962.1 - 4.3e-07 30.1 0.5 1.7e-06 28.2 0.5 2.2 1 1 0 1 1 1 1 Dynamin family RHD3 PF05879.12 PIK37962.1 - 1.9e-06 26.4 0.1 3.4e-06 25.5 0.0 1.4 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 PIK37962.1 - 0.0004 20.4 0.0 0.00077 19.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MCM PF00493.23 PIK37962.1 - 0.018 14.1 0.4 0.037 13.1 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain AAA_16 PF13191.6 PIK37962.1 - 0.018 15.4 0.0 0.033 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK37962.1 - 0.059 13.9 0.1 0.093 13.2 0.1 1.6 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 PIK37962.1 - 0.097 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Dynamin_N PF00350.23 PIK37964.1 - 4.3e-07 30.1 0.3 2.9e-06 27.4 0.1 2.3 1 1 1 2 2 2 1 Dynamin family RHD3 PF05879.12 PIK37964.1 - 1.2e-06 27.0 0.4 5e-06 25.0 0.0 2.0 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 PIK37964.1 - 1.7e-06 27.5 0.0 3.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 PIK37964.1 - 0.00012 22.1 0.1 0.00041 20.4 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase DASH_Spc19 PF08287.11 PIK37964.1 - 0.01 15.7 1.5 0.8 9.6 0.7 2.3 2 0 0 2 2 2 0 Spc19 Tli4_N PF18443.1 PIK37964.1 - 0.033 14.6 0.3 0.3 11.5 0.0 2.6 3 0 0 3 3 3 0 Tle cognate immunity protein 4 N-terminal domain DED PF01335.21 PIK37965.1 - 0.0051 17.1 0.0 0.0087 16.3 0.0 1.4 1 0 0 1 1 1 1 Death effector domain Sad1_UNC PF07738.13 PIK37967.1 - 7.2e-20 71.3 0.0 1.3e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Baculo_PEP_C PF04513.12 PIK37967.1 - 0.013 15.6 0.5 0.023 14.7 0.5 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ACT_6 PF13740.6 PIK37967.1 - 0.014 15.4 0.1 0.041 13.9 0.1 1.7 1 0 0 1 1 1 0 ACT domain dNK PF01712.19 PIK37967.1 - 0.015 15.2 0.4 0.03 14.2 0.4 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase Cob_adeno_trans PF01923.18 PIK37967.1 - 0.089 12.9 0.4 0.32 11.1 0.4 1.9 1 0 0 1 1 1 0 Cobalamin adenosyltransferase LOH1CR12 PF10158.9 PIK37967.1 - 0.13 12.3 2.2 0.54 10.3 2.2 1.9 1 1 0 1 1 1 0 Tumour suppressor protein DUF1664 PF07889.12 PIK37967.1 - 0.28 11.2 4.0 0.66 10.0 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 PIK37967.1 - 3.3 7.9 9.1 3.7 7.7 7.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ADK PF00406.22 PIK37968.1 - 6.6e-70 234.1 0.7 1.4e-41 142.1 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 PIK37968.1 - 1.1e-47 161.9 4.6 3.7e-25 88.9 0.2 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 PIK37968.1 - 4.3e-10 40.2 0.3 2.9e-05 24.6 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 PIK37968.1 - 1e-08 35.4 0.2 4.3e-05 23.7 0.0 3.5 2 2 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 PIK37968.1 - 0.00016 22.1 2.5 0.015 15.6 0.1 2.9 2 2 0 2 2 2 1 Hydin Adenylate kinase-like domain Zeta_toxin PF06414.12 PIK37968.1 - 0.00017 21.0 0.5 0.00017 21.0 0.5 1.8 2 0 0 2 2 2 1 Zeta toxin Cytidylate_kin PF02224.18 PIK37968.1 - 0.00019 21.3 0.0 0.021 14.6 0.0 3.0 3 0 0 3 3 3 1 Cytidylate kinase AAA_28 PF13521.6 PIK37968.1 - 0.0086 16.3 0.1 1.6 8.9 0.0 2.6 3 0 0 3 3 3 1 AAA domain CobU PF02283.16 PIK37968.1 - 0.012 15.2 2.6 0.076 12.6 0.0 3.2 3 1 1 4 4 4 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Thymidylate_kin PF02223.17 PIK37968.1 - 0.038 13.7 0.9 3.8 7.1 0.1 3.0 3 0 0 3 3 3 0 Thymidylate kinase 3-dmu-9_3-mt PF06983.13 PIK37968.1 - 0.19 12.3 0.7 9.3 6.8 0.1 3.2 4 0 0 4 4 4 0 3-demethylubiquinone-9 3-methyltransferase AAA_19 PF13245.6 PIK37968.1 - 0.3 11.4 1.8 0.87 9.9 0.2 2.6 2 1 1 3 3 3 0 AAA domain Cytidylate_kin2 PF13189.6 PIK37968.1 - 0.92 9.6 4.5 4.2 7.5 0.2 2.9 2 2 0 2 2 2 0 Cytidylate kinase-like family ADK PF00406.22 PIK37969.1 - 1.4e-15 57.7 0.2 2.2e-15 57.0 0.2 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 PIK37969.1 - 5.7e-05 23.6 0.2 0.00012 22.5 0.2 1.5 1 0 0 1 1 1 1 AAA domain Peptidase_C13 PF01650.18 PIK37970.1 - 1.4e-46 159.1 0.1 1.9e-46 158.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 PIK37970.1 - 0.0071 16.6 0.1 0.019 15.2 0.1 1.7 1 0 0 1 1 1 1 Mid domain of argonaute Glyco_transf_29 PF00777.18 PIK37971.1 - 1.2e-34 119.9 0.5 3.9e-29 101.9 0.5 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) Carn_acyltransf PF00755.20 PIK37972.1 - 4.6e-137 458.1 0.0 5.7e-137 457.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Carn_acyltransf PF00755.20 PIK37973.1 - 1.7e-44 152.5 0.0 1.8e-44 152.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase TGT PF01702.18 PIK37974.1 - 4.1e-93 312.3 0.0 4.9e-93 312.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Lectin_C PF00059.21 PIK37975.1 - 1e-21 77.7 0.3 5.4e-14 52.8 0.3 2.3 2 0 0 2 2 2 2 Lectin C-type domain UL45 PF05473.12 PIK37975.1 - 1.8e-08 34.3 0.0 0.00097 18.8 0.0 2.4 2 1 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like F5_F8_type_C PF00754.25 PIK37975.1 - 8.8e-07 29.1 0.0 1.6e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Chordopox_A33R PF05966.12 PIK37975.1 - 0.035 13.4 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus A33R protein VWD PF00094.25 PIK37976.1 - 3e-22 79.6 0.0 5.7e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain F5_F8_type_C PF00754.25 PIK37976.1 - 0.001 19.2 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain EGF_Tenascin PF18720.1 PIK37976.1 - 0.58 10.3 16.9 1.2 9.2 0.4 4.1 3 0 0 3 3 3 0 Tenascin EGF domain Lectin_C PF00059.21 PIK37977.1 - 1.2e-07 32.4 0.0 2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain F5_F8_type_C PF00754.25 PIK37978.1 - 6.1e-10 39.3 0.0 9.2e-06 25.8 0.0 2.1 2 0 0 2 2 2 2 F5/8 type C domain DDHD PF02862.17 PIK37979.1 - 2.4e-57 194.7 0.1 7.2e-55 186.6 0.0 2.5 2 0 0 2 2 2 2 DDHD domain WWE PF02825.20 PIK37979.1 - 2.9e-11 43.8 2.0 3.3e-06 27.6 0.2 2.6 1 1 1 2 2 2 2 WWE domain SAM_1 PF00536.30 PIK37979.1 - 1.1e-08 35.4 0.1 2.4e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 PIK37979.1 - 0.17 12.0 0.0 0.53 10.4 0.0 1.8 1 0 0 1 1 1 0 IGR protein motif Allatostatin PF05953.12 PIK37980.1 - 0.3 11.8 1.9 25 5.9 0.3 2.7 2 0 0 2 2 2 0 Allatostatin DNA_pol_B_thumb PF14791.6 PIK37981.1 - 5.7e-23 80.9 0.0 6.6e-23 80.7 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase beta thumb LPD7 PF18821.1 PIK37981.1 - 0.12 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 DNA_pol_B_palm PF14792.6 PIK37982.1 - 4e-29 101.1 0.0 8.2e-29 100.1 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 PIK37982.1 - 1.1e-18 66.8 0.2 6e-18 64.4 0.2 2.2 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 PIK37982.1 - 5.1e-18 65.2 0.1 1.3e-17 63.9 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain BRCT_2 PF16589.5 PIK37982.1 - 9.4e-05 22.7 0.3 0.0002 21.7 0.3 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK37982.1 - 0.00011 22.0 0.1 0.0003 20.6 0.1 1.7 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Cdd1 PF11731.8 PIK37982.1 - 0.00059 20.0 0.0 0.025 14.8 0.0 2.7 2 1 1 3 3 3 1 Pathogenicity locus HHH_5 PF14520.6 PIK37982.1 - 0.0014 19.2 0.1 3.6 8.3 0.0 3.0 3 0 0 3 3 3 2 Helix-hairpin-helix domain DUF4168 PF13767.6 PIK37982.1 - 0.0074 17.4 0.2 0.029 15.5 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4168) BRCT PF00533.26 PIK37982.1 - 0.013 15.9 0.1 0.034 14.5 0.1 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain P33MONOX PF15302.6 PIK37982.1 - 0.036 13.8 1.5 0.059 13.1 0.4 1.8 2 0 0 2 2 2 0 P33 mono-oxygenase IMS_HHH PF11798.8 PIK37982.1 - 0.087 13.2 0.0 6.1 7.4 0.0 2.7 2 0 0 2 2 2 0 IMS family HHH motif RCC1 PF00415.18 PIK37983.1 - 5.3e-34 116.6 8.9 8.2e-12 45.6 1.1 5.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK37983.1 - 1.4e-21 75.7 12.7 3.1e-08 33.2 1.3 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 PIK37983.1 - 0.15 11.7 0.0 32 4.2 0.0 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split DNA_pol_lambd_f PF10391.9 PIK37984.1 - 4e-18 65.0 0.0 9e-18 63.9 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 PIK37984.1 - 6.4e-10 39.3 0.0 2.7e-08 34.1 0.1 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain TMEM215 PF15746.5 PIK37984.1 - 0.013 14.9 0.6 0.02 14.4 0.6 1.2 1 0 0 1 1 1 0 TMEM215 family DNA_pol_B_palm PF14792.6 PIK37984.1 - 0.033 14.4 0.4 0.68 10.2 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase beta palm HHH_5 PF14520.6 PIK37984.1 - 0.045 14.4 0.0 16 6.2 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain Cdd1 PF11731.8 PIK37984.1 - 0.065 13.5 0.0 0.23 11.7 0.0 2.0 2 0 0 2 2 2 0 Pathogenicity locus DUF4500 PF14937.6 PIK37985.1 - 3.4e-31 107.1 0.1 4.2e-31 106.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) DUF533 PF04391.12 PIK37985.1 - 0.086 12.4 0.0 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) MA3 PF02847.17 PIK37986.1 - 1.7e-39 134.3 0.3 1.2e-18 67.2 0.0 2.3 2 0 0 2 2 2 2 MA3 domain Pkinase PF00069.25 PIK37987.1 - 1e-51 175.9 0.0 1.1e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK37987.1 - 3e-36 125.0 0.0 3.4e-36 124.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK37987.1 - 0.00013 20.9 0.0 0.00018 20.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK37987.1 - 0.00019 20.9 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK37987.1 - 0.0051 15.8 0.1 0.0068 15.4 0.1 1.3 1 1 0 1 1 1 1 Haspin like kinase domain WaaY PF06176.11 PIK37987.1 - 0.0081 15.8 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 PIK37987.1 - 0.01 15.8 0.0 0.045 13.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK37987.1 - 0.058 12.7 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 PIK37988.1 - 1.5e-05 24.5 0.0 2e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Phage_int_SAM_4 PF13495.6 PIK37990.1 - 0.00016 22.0 0.1 0.00031 21.1 0.1 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK37990.1 - 0.00053 20.2 0.3 0.001 19.3 0.3 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_5 PF13102.6 PIK37990.1 - 0.17 12.3 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain EF-hand_3 PF09069.11 PIK37991.1 - 1.3e-19 70.4 0.0 3.3e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand ZZ PF00569.17 PIK37991.1 - 1.5e-10 40.7 8.8 2.7e-10 39.9 8.8 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 PIK37991.1 - 0.001 19.4 6.3 0.0024 18.2 6.3 1.6 1 0 0 1 1 1 1 C1 domain MerR-DNA-bind PF09278.11 PIK37991.1 - 0.04 14.5 0.8 0.086 13.4 0.8 1.5 1 0 0 1 1 1 0 MerR, DNA binding CRISPR_Cse2 PF09485.10 PIK37991.1 - 0.17 12.4 2.1 0.2 12.2 0.8 1.8 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) TIM PF00121.18 PIK37991.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Triosephosphate isomerase LIG3_BRCT PF16759.5 PIK37992.1 - 4.5e-11 42.9 0.9 4.9e-10 39.6 0.3 2.9 2 1 0 2 2 2 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 PIK37992.1 - 4.5e-08 33.4 0.1 3.5e-07 30.5 0.1 2.4 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK37992.1 - 2.8e-05 24.4 0.0 0.00019 21.7 0.0 2.5 2 2 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain dbPDZ_assoc PF16610.5 PIK37992.1 - 0.77 10.0 5.0 0.13 12.5 0.8 1.9 2 0 0 2 2 2 0 Unstructured region between two PDZ domains on Dlg5 SNF2_N PF00176.23 PIK37993.1 - 2.5e-59 200.8 0.7 1.4e-58 198.3 0.7 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK37993.1 - 2e-16 60.3 0.0 2.1e-14 53.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK37993.1 - 2.8e-12 47.0 0.0 6.6e-11 42.5 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK37993.1 - 4.4e-09 36.4 0.0 7.7e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 PIK37993.1 - 2e-05 23.9 0.0 3.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 PIK37993.1 - 4.5e-05 22.8 0.0 7.8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 PIK37993.1 - 0.00019 21.2 0.0 0.00078 19.2 0.0 1.9 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 PIK37993.1 - 0.17 12.2 0.3 0.68 10.2 0.3 2.1 1 1 0 1 1 1 0 AAA domain SNF PF00209.18 PIK37994.1 - 6.3e-165 549.8 27.7 7.5e-165 549.6 27.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Caveolin PF01146.17 PIK37994.1 - 0.24 11.4 7.2 0.19 11.7 3.2 2.4 2 0 0 2 2 2 0 Caveolin SNF PF00209.18 PIK37995.1 - 1.6e-167 558.4 34.0 1e-128 430.3 18.6 2.2 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family Caveolin PF01146.17 PIK37995.1 - 4.2 7.3 12.5 0.046 13.7 4.0 2.1 2 0 0 2 2 2 0 Caveolin Cyt-b5 PF00173.28 PIK37996.1 - 3.5e-07 30.3 0.0 4.6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-U1 PF06220.12 PIK37997.1 - 4.7e-10 39.1 0.3 9e-10 38.2 0.3 1.5 1 0 0 1 1 1 1 U1 zinc finger WW PF00397.26 PIK37997.1 - 0.0005 20.1 7.0 0.0013 18.8 7.0 1.7 1 0 0 1 1 1 1 WW domain T4_Rnl2_C PF18043.1 PIK37997.1 - 0.0028 17.7 2.0 0.0028 17.7 2.0 2.2 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal zf-DBF PF07535.12 PIK37997.1 - 0.052 13.7 0.4 0.13 12.4 0.4 1.7 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2_jaz PF12171.8 PIK37997.1 - 0.079 13.3 4.2 0.48 10.8 4.2 2.4 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF4523 PF15023.6 PIK37997.1 - 0.082 12.7 1.9 0.85 9.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Endonuc_Holl PF10107.9 PIK37998.1 - 1 9.2 6.8 0.063 13.1 1.8 1.5 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase zf_UBZ PF18439.1 PIK37999.1 - 0.004 16.7 0.2 0.008 15.7 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-C2H2_3 PF13878.6 PIK37999.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_11 PF16622.5 PIK37999.1 - 0.22 11.3 0.2 0.37 10.6 0.2 1.3 1 0 0 1 1 1 0 zinc-finger C2H2-type Rot1 PF10681.9 PIK38000.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal Frag1 PF10277.9 PIK38002.1 - 1.5e-33 116.2 23.9 2.7e-33 115.4 23.9 1.3 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family EVC2_like PF12297.8 PIK38002.1 - 0.019 13.7 1.4 0.028 13.1 1.4 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Peptidase_C12 PF01088.21 PIK38003.1 - 1.4e-14 54.3 0.0 1.6e-14 54.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Herpes_IE2_3 PF03361.14 PIK38003.1 - 0.0031 17.4 0.0 0.0031 17.4 0.0 1.1 1 0 0 1 1 1 1 Herpes virus intermediate/early protein 2/3 NUC205 PF08168.11 PIK38003.1 - 0.037 13.5 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 NUC205 domain rve PF00665.26 PIK38004.1 - 4.4e-06 26.9 1.1 6.6e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain AIG1 PF04548.16 PIK38004.1 - 7.9e-06 25.3 0.3 7.9e-06 25.3 0.3 3.0 2 1 1 3 3 3 2 AIG1 family RVT_1 PF00078.27 PIK38004.1 - 2.1e-05 24.1 0.2 5.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK38004.1 - 0.18 11.6 0.0 0.18 11.6 0.0 2.8 3 0 0 3 3 3 0 Integrase core domain PDZ PF00595.24 PIK38006.1 - 2.7e-59 197.5 17.9 4.9e-17 62.1 0.2 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK38006.1 - 9.5e-28 95.8 5.4 3e-07 30.2 0.2 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK38006.1 - 4.6e-27 94.2 8.6 3.5e-08 33.7 0.2 4.3 4 0 0 4 4 4 4 PDZ domain zf-TRAF PF02176.18 PIK38006.1 - 2e-07 31.6 2.4 5.7e-07 30.1 2.4 1.8 1 0 0 1 1 1 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 PIK38006.1 - 8.8e-07 28.7 8.3 8.8e-07 28.7 8.3 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Tricorn_PDZ PF14685.6 PIK38006.1 - 5.7e-06 26.2 3.1 2 8.4 0.0 4.4 4 0 0 4 4 4 1 Tricorn protease PDZ domain zf-C3HC4 PF00097.25 PIK38006.1 - 6.4e-06 25.9 7.4 6.4e-06 25.9 7.4 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK38006.1 - 3.3e-05 23.8 4.6 3.3e-05 23.8 4.6 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK38006.1 - 9.9e-05 22.6 5.9 9.9e-05 22.6 5.9 3.2 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK38006.1 - 0.00013 21.9 7.0 0.00013 21.9 7.0 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK38006.1 - 0.00028 20.7 4.0 0.00028 20.7 4.0 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PDZ_4 PF17816.1 PIK38006.1 - 0.001 19.4 0.6 9.9 6.6 0.0 4.1 4 0 0 4 4 4 0 PDZ domain zf-C3HC4_4 PF15227.6 PIK38006.1 - 0.0011 19.1 6.0 0.0011 19.1 6.0 2.7 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING Phage_tail_APC PF16778.5 PIK38006.1 - 0.009 15.9 0.1 13 5.8 0.0 3.3 3 0 0 3 3 3 0 Phage tail assembly chaperone protein Sina PF03145.16 PIK38006.1 - 0.012 15.6 0.9 0.025 14.5 0.9 1.5 1 0 0 1 1 1 0 Seven in absentia protein family LIME1 PF15332.6 PIK38006.1 - 0.056 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Lck-interacting transmembrane adapter 1 Lys-AminoMut_A PF09043.11 PIK38006.1 - 0.057 11.9 0.3 0.091 11.2 0.3 1.2 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit zf-rbx1 PF12678.7 PIK38006.1 - 0.16 12.3 12.0 0.036 14.4 7.1 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain DZR PF12773.7 PIK38006.1 - 8.3 6.5 9.8 41 4.3 4.5 2.9 1 1 1 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.6 PIK38006.1 - 8.6 6.3 8.6 4 7.4 5.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 PIK38006.1 - 8.8 6.6 13.4 2.1 8.5 5.6 3.2 2 1 1 3 3 3 0 zinc RING finger of MSL2 HMG_box PF00505.19 PIK38007.1 - 4.6e-27 94.2 3.5 8.2e-27 93.4 3.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box SOXp PF12336.8 PIK38007.1 - 2.4e-17 63.8 3.6 2.4e-17 63.8 3.6 3.1 3 1 0 3 3 3 1 SOX transcription factor HMG_box_2 PF09011.10 PIK38007.1 - 2.6e-11 44.0 2.7 4.5e-11 43.2 2.7 1.4 1 0 0 1 1 1 1 HMG-box domain zf-H2C2_2 PF13465.6 PIK38008.1 - 3.1e-34 115.9 34.5 4e-09 36.5 2.6 6.0 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK38008.1 - 4.2e-20 70.7 36.1 7.8e-05 23.2 1.0 6.3 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK38008.1 - 2.7e-18 65.3 44.8 1.8e-05 24.9 0.9 6.5 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK38008.1 - 1.5e-10 41.1 21.6 2e-05 24.7 2.1 5.4 5 1 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK38008.1 - 3.6e-07 30.4 30.0 0.00053 20.3 2.5 5.6 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK38008.1 - 3.5e-05 23.7 0.2 3.5e-05 23.7 0.2 6.2 6 0 0 6 6 6 2 C2H2-type zinc finger C1_4 PF07975.12 PIK38008.1 - 0.00012 22.2 11.7 0.037 14.3 0.4 3.4 3 0 0 3 3 3 2 TFIIH C1-like domain zf-AN1 PF01428.16 PIK38008.1 - 0.00076 19.6 18.8 2.8 8.2 0.4 5.3 5 0 0 5 5 5 1 AN1-like Zinc finger Ta0938 PF11494.8 PIK38008.1 - 0.0021 18.3 0.5 0.058 13.7 0.0 2.4 1 1 2 3 3 3 1 Ta0938 zf-H2C2_5 PF13909.6 PIK38008.1 - 0.0039 16.9 2.3 0.0039 16.9 2.3 6.0 6 2 0 6 6 5 1 C2H2-type zinc-finger domain PyrI_C PF02748.15 PIK38008.1 - 0.037 13.9 14.0 5.6 6.9 0.0 4.7 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 PIK38008.1 - 0.05 13.6 19.9 1.4 9.0 0.4 4.9 3 1 3 6 6 6 0 BED zinc finger DUF3268 PF11672.8 PIK38008.1 - 0.051 13.9 9.7 0.19 12.0 0.6 2.8 2 1 1 3 3 3 0 zinc-finger-containing domain Elf1 PF05129.13 PIK38008.1 - 0.06 13.4 20.8 0.54 10.4 0.5 4.6 2 1 3 5 5 5 0 Transcription elongation factor Elf1 like zf_UBZ PF18439.1 PIK38008.1 - 0.064 12.9 16.6 1.5 8.5 0.3 5.6 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Siva PF05458.12 PIK38008.1 - 0.071 12.8 4.6 1.6 8.4 0.2 2.4 1 1 1 2 2 2 0 Cd27 binding protein (Siva) zinc_ribbon_15 PF17032.5 PIK38008.1 - 0.078 13.7 11.9 2.7 8.8 2.0 3.2 1 1 2 3 3 3 0 zinc-ribbon family Scramblase PF03803.15 PIK38008.1 - 0.17 11.1 1.4 2.3 7.5 0.3 2.0 1 1 1 2 2 2 0 Scramblase zinc-ribbons_6 PF07191.12 PIK38008.1 - 0.18 11.8 16.1 6.6 6.8 1.2 4.2 1 1 2 3 3 3 0 zinc-ribbons zf-C2HE PF16278.5 PIK38008.1 - 0.25 11.8 0.4 0.25 11.8 0.4 5.4 3 3 3 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 PIK38008.1 - 0.25 11.7 18.1 8.5 6.8 0.1 4.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK38008.1 - 0.35 10.7 0.0 0.35 10.7 0.0 5.3 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-MYST PF17772.1 PIK38008.1 - 0.51 10.0 10.1 9.2 6.0 0.2 4.1 2 1 2 4 4 4 0 MYST family zinc finger domain HypA PF01155.19 PIK38008.1 - 0.57 10.2 12.3 5.1 7.2 4.4 3.0 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-FCS PF06467.14 PIK38008.1 - 0.69 9.9 21.6 0.93 9.5 0.6 4.8 3 2 2 5 5 5 0 MYM-type Zinc finger with FCS sequence motif Zn-ribbon_8 PF09723.10 PIK38008.1 - 0.75 10.0 19.5 0.31 11.2 3.4 3.8 2 1 2 4 4 4 0 Zinc ribbon domain Zf_RING PF16744.5 PIK38008.1 - 0.76 9.9 15.1 8.9 6.5 0.1 4.9 1 1 4 5 5 5 0 KIAA1045 RING finger zf-C2H2_9 PF16293.5 PIK38008.1 - 0.83 9.5 4.0 29 4.6 0.1 3.6 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) FYVE PF01363.21 PIK38008.1 - 1 9.5 22.3 15 5.8 0.1 4.8 1 1 3 4 4 4 0 FYVE zinc finger LIM PF00412.22 PIK38008.1 - 1.6 9.0 18.9 13 6.1 0.2 4.6 1 1 4 5 5 5 0 LIM domain Zn_Tnp_IS1595 PF12760.7 PIK38008.1 - 1.8 8.6 0.0 1.8 8.6 0.0 4.0 2 1 3 5 5 5 0 Transposase zinc-ribbon domain CpXC PF14353.6 PIK38008.1 - 2.5 8.2 17.1 8.4 6.5 0.2 4.6 2 1 2 4 4 4 0 CpXC protein ATPase-cat_bd PF12156.8 PIK38008.1 - 3.5 8.4 14.6 1 10.2 0.8 3.2 3 0 0 3 3 3 0 Putative metal-binding domain of cation transport ATPase PHD PF00628.29 PIK38008.1 - 4.6 7.2 17.0 36 4.4 0.1 4.2 2 1 2 4 4 4 0 PHD-finger Transposase_21 PF02992.14 PIK38009.1 - 0.00013 21.3 0.0 0.00027 20.3 0.0 1.5 1 0 0 1 1 1 1 Transposase family tnp2 zf-C2H2_aberr PF17017.5 PIK38009.1 - 0.064 13.4 2.0 0.21 11.7 0.3 2.5 2 1 0 2 2 2 0 Aberrant zinc-finger TMEM154 PF15102.6 PIK38010.1 - 0.00032 20.6 0.3 0.00039 20.4 0.3 1.2 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 PIK38010.1 - 0.00037 21.3 0.1 0.00052 20.8 0.1 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 PIK38010.1 - 0.00044 19.9 6.4 0.00067 19.4 6.4 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Cadherin_C_2 PF16492.5 PIK38010.1 - 0.0032 18.2 0.0 0.005 17.6 0.0 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal DUF3827 PF12877.7 PIK38010.1 - 0.0081 14.6 0.2 0.0093 14.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) DUF4834 PF16118.5 PIK38010.1 - 0.013 16.4 0.0 0.019 15.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF5305 PF17231.2 PIK38010.1 - 0.019 14.4 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Ninjurin PF04923.12 PIK38010.1 - 0.034 14.1 0.1 0.046 13.7 0.1 1.1 1 0 0 1 1 1 0 Ninjurin DUF3377 PF11857.8 PIK38010.1 - 0.042 13.8 5.0 0.069 13.1 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Ly49 PF08391.10 PIK38010.1 - 0.044 14.2 0.0 0.064 13.6 0.0 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Orf78 PF06024.12 PIK38010.1 - 0.063 13.6 0.1 0.091 13.1 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF5527 PF17665.1 PIK38010.1 - 0.074 12.6 1.4 0.096 12.2 1.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) IgaA PF07095.11 PIK38010.1 - 0.075 11.0 0.0 0.086 10.8 0.0 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA DUF2207 PF09972.9 PIK38010.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Protocadherin PF08374.11 PIK38010.1 - 0.14 12.1 1.2 0.17 11.8 0.8 1.3 1 1 0 1 1 1 0 Protocadherin Insulin_TMD PF17870.1 PIK38010.1 - 0.25 11.5 4.8 0.48 10.5 4.8 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RIFIN PF02009.16 PIK38010.1 - 0.68 9.8 3.6 0.94 9.3 3.6 1.1 1 0 0 1 1 1 0 Rifin LRRC37AB_C PF14914.6 PIK38010.1 - 0.74 9.7 4.8 1.3 9.0 4.8 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Collectrin PF16959.5 PIK38010.1 - 0.89 9.3 3.0 1.3 8.8 3.0 1.2 1 0 0 1 1 1 0 Renal amino acid transporter RR_TM4-6 PF06459.12 PIK38011.1 - 0.026 14.4 2.6 0.041 13.7 2.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BEN PF10523.9 PIK38011.1 - 0.028 14.6 0.0 0.076 13.3 0.0 1.7 1 0 0 1 1 1 0 BEN domain B277 PF17623.2 PIK38011.1 - 5.5 6.0 6.1 3 6.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function Transposase_21 PF02992.14 PIK38012.1 - 2.7e-12 46.4 0.1 5.9e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 Transposase family tnp2 DUF1258 PF06869.12 PIK38012.1 - 4.1e-08 33.0 0.2 4.1e-08 33.0 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1258) AHH PF14412.6 PIK38013.1 - 0.0037 17.3 0.5 0.0045 17.0 0.5 1.1 1 0 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DHHC PF01529.20 PIK38014.1 - 6.9e-30 103.9 4.5 6.9e-30 103.9 4.5 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Na_H_Exchanger PF00999.21 PIK38014.1 - 0.0013 17.6 3.8 0.0013 17.6 3.8 1.8 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family Ceramidase PF05875.12 PIK38014.1 - 0.0031 17.0 0.2 0.0073 15.8 0.2 1.6 1 0 0 1 1 1 1 Ceramidase DUF485 PF04341.12 PIK38014.1 - 2.3 8.2 8.0 0.41 10.6 3.2 2.3 2 1 1 3 3 3 0 Protein of unknown function, DUF485 AA_permease_2 PF13520.6 PIK38014.1 - 2.4 6.9 11.4 3.9 6.2 5.9 2.1 2 0 0 2 2 2 0 Amino acid permease DUF4131 PF13567.6 PIK38014.1 - 10 5.8 10.7 4 7.1 1.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) PQQ PF01011.21 PIK38015.1 - 0.00013 21.8 0.1 0.021 14.7 0.0 3.0 3 0 0 3 3 3 1 PQQ enzyme repeat VCBS PF13517.6 PIK38015.1 - 0.0035 17.9 9.1 0.45 11.1 0.0 3.8 3 1 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TSP_3 PF02412.18 PIK38015.1 - 0.55 10.0 3.0 1.4 8.6 3.0 1.7 1 0 0 1 1 1 0 Thrombospondin type 3 repeat Peptidase_C11 PF03415.14 PIK38016.1 - 0.036 13.5 0.4 1.4 8.2 0.1 2.1 2 0 0 2 2 2 0 Clostripain family Exo_endo_phos_2 PF14529.6 PIK38017.1 - 3.5e-06 26.8 0.0 5.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK38017.1 - 0.0066 16.0 0.0 0.014 15.0 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Death PF00531.22 PIK38019.1 - 3.7e-16 59.0 1.2 7.3e-16 58.1 1.2 1.5 1 0 0 1 1 1 1 Death domain p450 PF00067.22 PIK38021.1 - 4.5e-29 101.5 0.0 5.7e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SDA1 PF05285.12 PIK38021.1 - 5.2e-05 22.8 32.5 7.6e-05 22.3 32.5 1.3 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 PIK38021.1 - 0.0032 15.8 37.4 0.004 15.4 37.4 1.2 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 PIK38021.1 - 0.007 15.8 27.7 0.0088 15.4 27.7 1.2 1 0 0 1 1 1 1 BUD22 SpoIIIAH PF12685.7 PIK38021.1 - 0.056 13.3 9.0 0.11 12.4 9.0 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein SAPS PF04499.15 PIK38021.1 - 0.062 12.1 10.2 0.067 12.0 10.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mpp10 PF04006.12 PIK38021.1 - 0.077 11.4 31.9 0.12 10.8 31.9 1.3 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.12 PIK38021.1 - 0.63 9.0 5.1 0.95 8.4 5.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Paf1 PF03985.13 PIK38021.1 - 0.76 8.7 24.2 0.55 9.2 22.2 1.7 2 0 0 2 2 2 0 Paf1 RNA_pol_Rpc4 PF05132.14 PIK38021.1 - 1.3 9.4 6.7 2.4 8.6 6.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 PIK38021.1 - 3.4 7.4 10.7 7.2 6.3 10.7 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SURF2 PF05477.11 PIK38021.1 - 5.1 6.7 17.9 9.4 5.9 17.9 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Herpes_LMP1 PF05297.11 PIK38021.1 - 8.5 5.5 17.7 12 5.0 17.7 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) p450 PF00067.22 PIK38022.1 - 1.1e-72 245.3 0.0 1.3e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF5060 PF16586.5 PIK38022.1 - 0.015 15.7 0.1 0.057 13.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5060) Strep_his_triad PF04270.13 PIK38022.1 - 0.13 12.3 0.1 2.7 8.1 0.0 2.5 2 1 0 2 2 2 0 Streptococcal histidine triad protein ASC PF00858.24 PIK38023.1 - 1.5e-83 281.3 14.5 1.9e-83 280.9 14.5 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Fibrinogen_C PF00147.18 PIK38024.1 - 6.4e-21 75.2 3.0 7.1e-21 75.0 3.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PsbX PF06596.11 PIK38024.1 - 0.031 14.3 0.7 0.052 13.5 0.7 1.2 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Fibrinogen_C PF00147.18 PIK38025.1 - 1.9e-65 220.8 9.3 2.2e-65 220.5 9.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38026.1 - 2e-42 145.5 1.5 2.7e-42 145.1 1.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ASC PF00858.24 PIK38027.1 - 8e-28 97.6 0.9 9.2e-28 97.4 0.9 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Fibrinogen_C PF00147.18 PIK38028.1 - 2.8e-74 249.6 12.5 1.8e-63 214.3 8.5 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38028.1 - 5.5e-06 26.5 19.4 5.5e-06 26.5 19.4 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38028.1 - 0.014 15.5 4.2 0.014 15.5 4.2 3.6 3 0 0 3 3 3 0 EGF domain Fibrinogen_C PF00147.18 PIK38029.1 - 1.9e-82 276.4 12.7 4e-48 164.1 6.0 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38029.1 - 1.3e-06 28.6 20.1 1.3e-06 28.6 20.1 2.3 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain TPR_19 PF14559.6 PIK38030.1 - 7.2e-10 39.2 4.0 0.036 14.6 0.0 5.4 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK38030.1 - 5.2e-06 26.2 13.8 1.3 9.3 0.1 7.6 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK38030.1 - 0.00038 20.7 4.0 6 7.2 0.0 5.9 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK38030.1 - 0.00039 20.6 0.6 18 6.0 0.0 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK38030.1 - 0.0008 20.0 2.7 58 4.9 0.0 6.0 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK38030.1 - 0.0023 17.7 11.2 0.13 12.2 0.1 6.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK38030.1 - 0.0058 17.2 10.9 5.8 7.8 0.3 8.2 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK38030.1 - 0.013 16.1 0.2 21 5.9 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK38030.1 - 0.025 14.8 17.2 3.9 7.9 0.1 8.1 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK38030.1 - 0.032 13.9 1.7 3.5 7.4 0.0 4.1 5 0 0 5 5 5 0 TPR repeat TrmO_C PF18389.1 PIK38030.1 - 0.067 13.3 0.1 0.28 11.3 0.1 2.1 1 0 0 1 1 1 0 TrmO C-terminal domain zf-C2H2 PF00096.26 PIK38031.1 - 0.00039 20.7 2.3 0.00069 19.9 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK38031.1 - 0.006 17.3 1.6 0.012 16.4 1.6 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 PIK38031.1 - 0.0072 16.7 0.6 0.012 15.9 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK38031.1 - 0.012 15.9 1.7 0.022 15.0 1.7 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding RUN PF02759.19 PIK38031.1 - 0.019 14.9 0.0 6.4 6.7 0.0 2.3 2 0 0 2 2 2 0 RUN domain zf-C2H2_6 PF13912.6 PIK38031.1 - 0.024 14.6 0.3 0.05 13.6 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Phage_TAC_2 PF06894.11 PIK38031.1 - 0.083 12.7 0.5 0.15 11.9 0.5 1.4 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly chaperone, TAC, protein G NACHT PF05729.12 PIK38032.1 - 8.7e-16 58.3 0.0 1.5e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Ig_2 PF13895.6 PIK38032.1 - 4.9e-05 23.6 0.1 0.11 12.8 0.0 3.2 2 1 1 3 3 3 1 Immunoglobulin domain NB-ARC PF00931.22 PIK38032.1 - 0.0002 20.7 0.0 0.00033 19.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain Ig_3 PF13927.6 PIK38032.1 - 0.00033 21.2 1.0 0.075 13.6 0.0 3.2 2 1 1 3 3 3 1 Immunoglobulin domain AAA_25 PF13481.6 PIK38032.1 - 0.0023 17.5 0.0 0.0063 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK38032.1 - 0.0069 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain V-set PF07686.17 PIK38032.1 - 0.02 15.1 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain AAA_16 PF13191.6 PIK38032.1 - 0.036 14.5 0.0 0.089 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain C2-set_2 PF08205.12 PIK38032.1 - 0.04 14.0 0.1 0.087 12.9 0.1 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DAP3 PF10236.9 PIK38032.1 - 0.044 12.9 0.0 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ig PF00047.25 PIK38032.1 - 0.16 12.2 0.6 0.45 10.7 0.0 2.1 3 0 0 3 3 3 0 Immunoglobulin domain ATG101 PF07855.12 PIK38035.1 - 2.8e-40 137.8 0.1 3.6e-40 137.5 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 KDZ PF18758.1 PIK38037.1 - 1.6e-27 96.6 0.3 1.6e-27 96.6 0.3 1.7 2 0 0 2 2 2 1 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK38037.1 - 0.011 15.9 0.1 0.044 13.9 0.1 2.1 1 0 0 1 1 1 0 CxC2 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK38037.1 - 0.015 15.1 0.2 0.043 13.6 0.2 1.8 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases MerR_1 PF13411.6 PIK38037.1 - 0.12 12.5 0.1 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 MerR HTH family regulatory protein Sulfotransfer_2 PF03567.14 PIK38039.1 - 1e-51 176.3 3.3 1.6e-51 175.7 3.3 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfolobus_pRN PF05584.11 PIK38039.1 - 0.17 11.9 1.1 3.2 7.9 0.2 2.4 2 0 0 2 2 2 0 Sulfolobus plasmid regulatory protein zf-B_box PF00643.24 PIK38040.1 - 9.7e-05 22.4 9.9 9.7e-05 22.4 9.9 3.0 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK38040.1 - 0.00049 19.9 12.6 0.00049 19.9 12.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK38040.1 - 0.011 15.6 15.9 0.011 15.6 15.9 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1132 PF06575.12 PIK38040.1 - 0.03 14.7 0.3 0.15 12.4 0.3 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1132) Tup_N PF08581.10 PIK38040.1 - 0.033 14.5 0.5 0.093 13.0 0.5 1.7 1 0 0 1 1 1 0 Tup N-terminal HAP1_N PF04849.13 PIK38040.1 - 0.045 13.0 4.7 0.085 12.1 2.2 2.5 2 1 1 3 3 3 0 HAP1 N-terminal conserved region Cucumo_coat PF00760.18 PIK38040.1 - 0.052 13.2 0.2 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Cucumovirus coat protein DUF2783 PF10932.8 PIK38041.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) TRAP_alpha PF03896.16 PIK38041.1 - 0.14 11.4 1.0 0.2 10.8 1.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit V-set PF07686.17 PIK38042.1 - 0.00022 21.3 0.3 0.00063 19.9 0.3 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain MBG PF17883.1 PIK38042.1 - 0.014 15.9 0.1 0.031 14.9 0.1 1.5 1 0 0 1 1 1 0 MBG domain I-set PF07679.16 PIK38042.1 - 0.058 13.5 0.2 0.61 10.2 0.0 2.5 3 0 0 3 3 3 0 Immunoglobulin I-set domain Ig_C17orf99 PF17736.1 PIK38044.1 - 0.0013 18.7 1.5 1.6 8.9 0.1 2.6 2 0 0 2 2 2 2 C17orf99 Ig domain V-set PF07686.17 PIK38044.1 - 0.002 18.3 0.1 0.0077 16.4 0.1 2.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK38044.1 - 0.16 12.1 4.1 5.2 7.2 0.1 3.6 3 1 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Hist_deacetyl PF00850.19 PIK38046.1 - 0.027 13.9 0.1 0.032 13.7 0.1 1.2 1 0 0 1 1 1 0 Histone deacetylase domain HTH_43 PF09904.9 PIK38047.1 - 0.022 14.7 1.2 4.3 7.4 0.4 2.3 1 1 1 2 2 2 0 Winged helix-turn helix RT_RNaseH_2 PF17919.1 PIK38048.1 - 6.7e-21 74.2 0.0 2.3e-20 72.5 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38048.1 - 9.4e-17 61.3 0.0 1.6e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK38048.1 - 2.1e-11 44.0 0.0 1.3e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK38049.1 - 6.7e-13 48.9 0.0 9e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK38049.1 - 0.0027 17.4 0.2 0.0047 16.7 0.2 1.4 1 1 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 PIK38050.1 - 0.018 15.1 0.2 0.018 15.1 0.2 2.2 2 0 0 2 2 2 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK38051.1 - 3.4e-09 36.6 0.1 8.9e-09 35.2 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38051.1 - 0.039 13.8 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK38052.1 - 9.3e-42 143.0 0.0 1.2e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK38052.1 - 0.096 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein DUF1759 PF03564.15 PIK38053.1 - 5.7e-18 65.3 3.4 1.6e-17 63.8 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1759) zf-CCHC_5 PF14787.6 PIK38053.1 - 0.0052 16.5 1.6 0.0052 16.5 1.6 2.5 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 PIK38053.1 - 0.11 12.7 14.1 0.55 10.4 1.8 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK38053.1 - 0.35 10.9 12.5 3.7 7.6 0.8 2.8 1 1 1 2 2 2 0 Zinc knuckle betaPIX_CC PF16523.5 PIK38053.1 - 1.2 9.0 7.5 4.8 7.1 3.9 2.7 2 0 0 2 2 2 0 betaPIX coiled coil Integrase_H2C2 PF17921.1 PIK38054.1 - 6.4e-12 45.4 0.4 1.2e-11 44.5 0.4 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK38054.1 - 9.8e-09 35.4 0.0 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK38054.1 - 0.0084 15.9 0.0 0.019 14.7 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF4006 PF13179.6 PIK38055.1 - 6.9e-05 22.7 0.1 0.00016 21.5 0.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF4006) TMEM154 PF15102.6 PIK38055.1 - 0.0029 17.5 0.1 0.0029 17.5 0.1 2.8 3 0 0 3 3 3 1 TMEM154 protein family Caskin-Pro-rich PF16907.5 PIK38055.1 - 0.13 12.8 1.7 0.4 11.2 1.5 2.0 1 1 0 1 1 1 0 Proline rich region of Caskin proteins Afaf PF15339.6 PIK38055.1 - 0.33 10.7 0.0 0.33 10.7 0.0 2.6 3 0 0 3 3 3 0 Acrosome formation-associated factor TCTP PF00838.17 PIK38056.1 - 2.6e-29 102.7 4.0 3.7e-14 53.4 1.5 2.1 1 1 1 2 2 2 2 Translationally controlled tumour protein YlbE PF14003.6 PIK38056.1 - 0.015 15.8 0.4 0.027 14.9 0.4 1.4 1 0 0 1 1 1 0 YlbE-like protein TCTP PF00838.17 PIK38057.1 - 1.3e-32 113.5 0.1 1.6e-32 113.2 0.1 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein YlbE PF14003.6 PIK38057.1 - 0.064 13.7 0.2 0.12 12.9 0.2 1.4 1 0 0 1 1 1 0 YlbE-like protein MukB PF04310.12 PIK38057.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 MukB N-terminal RhoGEF PF00621.20 PIK38058.1 - 5.5e-45 153.8 0.6 2.1e-44 151.9 0.2 2.0 2 0 0 2 2 2 1 RhoGEF domain PTCB-BRCT PF12738.7 PIK38058.1 - 3.3e-05 23.8 0.1 0.0009 19.1 0.0 2.9 2 1 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 PIK38058.1 - 8.1e-05 22.9 1.1 0.00056 20.2 0.1 2.7 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Fam20C PF06702.12 PIK38059.1 - 6.3e-33 114.4 2.0 7.6e-33 114.2 2.0 1.1 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK38059.1 - 0.00059 18.8 0.1 0.01 14.8 0.0 2.0 2 0 0 2 2 2 2 FAM198 protein Fam20C PF06702.12 PIK38060.1 - 1.1e-51 175.8 0.0 1.5e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK38060.1 - 0.00013 20.9 0.1 0.00044 19.2 0.0 1.8 2 0 0 2 2 2 1 FAM198 protein zinc_ribbon_2 PF13240.6 PIK38061.1 - 0.085 12.6 0.3 0.16 11.7 0.3 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Myosin_head PF00063.21 PIK38062.1 - 1.2e-224 747.5 1.1 1.4e-224 747.3 1.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 PIK38062.1 - 0.0083 16.4 0.0 0.025 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK38062.1 - 0.01 16.2 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK38062.1 - 0.014 15.9 0.0 0.039 14.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 PIK38062.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MyTH4 PF00784.17 PIK38063.1 - 1.1e-31 109.5 0.1 4.3e-31 107.6 0.0 2.1 2 0 0 2 2 2 1 MyTH4 domain IQ PF00612.27 PIK38063.1 - 3e-07 29.6 6.5 0.00053 19.6 1.4 3.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif FERM_N PF09379.10 PIK38063.1 - 1.7e-05 24.7 0.1 4.1e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 PIK38063.1 - 7.1e-05 23.2 0.1 0.00021 21.7 0.1 1.8 1 0 0 1 1 1 1 FERM central domain DUF4778 PF16008.5 PIK38063.1 - 0.0051 16.9 3.0 0.011 15.9 3.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4778) RA PF00788.23 PIK38063.1 - 0.0053 17.4 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain I-set PF07679.16 PIK38065.1 - 2.2e-07 30.8 0.0 3.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Receptor_2B4 PF11465.8 PIK38065.1 - 0.0023 18.1 0.1 0.0032 17.6 0.1 1.2 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 Ig_3 PF13927.6 PIK38065.1 - 0.0066 17.0 0.1 0.015 15.9 0.0 1.7 1 1 1 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK38065.1 - 0.01 16.0 0.1 0.014 15.5 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK38065.1 - 0.046 14.1 0.0 0.074 13.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain DUF3244 PF11589.8 PIK38065.1 - 0.072 13.2 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) CATSPERD PF15020.6 PIK38066.1 - 2.6e-61 207.9 4.4 3e-61 207.7 4.4 1.0 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit delta ARL2_Bind_BART PF11527.8 PIK38067.1 - 0.07 13.2 1.4 0.74 9.9 0.0 3.0 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART UCH PF00443.29 PIK38068.1 - 3.3e-11 43.2 0.0 1.8e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK38068.1 - 0.00028 20.6 0.0 0.00052 19.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 PIK38069.1 - 1.2e-29 103.6 1.3 5.1e-29 101.5 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK38069.1 - 2.4e-21 76.6 0.0 4e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DZR PF12773.7 PIK38069.1 - 0.19 11.8 2.5 0.45 10.6 2.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon CUE PF02845.16 PIK38070.1 - 9.8e-07 28.4 0.0 3.1e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 CUE domain DUF4404 PF14357.6 PIK38070.1 - 0.073 13.7 0.1 0.33 11.6 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Peptidase_S8 PF00082.22 PIK38071.1 - 3.2e-33 115.3 18.6 5.1e-33 114.6 18.6 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK38071.1 - 8.7e-05 23.1 0.0 0.00022 21.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 Zip PF02535.22 PIK38072.1 - 1e-23 84.1 11.8 1e-23 84.1 11.8 3.5 3 1 0 3 3 3 2 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK38072.1 - 3.1e-20 72.7 10.1 6e-18 65.3 1.3 2.3 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain DUF998 PF06197.13 PIK38072.1 - 0.37 10.4 4.2 0.74 9.4 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF998) SDA1 PF05285.12 PIK38072.1 - 4.8 6.5 8.9 7.4 5.9 8.9 1.2 1 0 0 1 1 1 0 SDA1 Peptidase_M7 PF02031.16 PIK38073.1 - 0.013 15.6 0.0 0.94 9.6 0.1 2.3 2 0 0 2 2 2 0 Streptomyces extracellular neutral proteinase (M7) family KN17_SH3 PF18131.1 PIK38073.1 - 0.051 13.7 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 KN17 SH3-like C-terminal domain KOW PF00467.29 PIK38073.1 - 0.3 11.1 0.8 0.49 10.4 0.8 1.3 1 0 0 1 1 1 0 KOW motif SH3_1 PF00018.28 PIK38074.1 - 6.6e-12 44.9 0.3 6.6e-12 44.9 0.3 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK38074.1 - 1.5e-09 37.6 0.4 1.5e-09 37.6 0.4 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK38074.1 - 2.8e-08 33.3 0.1 5.2e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK38074.1 - 0.028 14.7 1.0 0.048 13.9 1.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain eIF3_subunit PF08597.10 PIK38074.1 - 0.14 12.1 7.4 0.17 11.8 7.4 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Spt5_N PF11942.8 PIK38074.1 - 2 9.5 7.6 3.3 8.7 7.6 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal BAR_3_WASP_bdg PF10456.9 PIK38075.1 - 8.2e-83 277.5 4.6 1.3e-82 276.8 4.6 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 PIK38075.1 - 4.6e-22 78.1 3.1 1.4e-21 76.6 0.1 2.8 3 1 0 3 3 3 1 PX domain Vps5 PF09325.10 PIK38075.1 - 5.9e-06 26.0 2.8 0.09 12.3 2.4 2.9 2 1 1 3 3 3 2 Vps5 C terminal like NHR2 PF08788.11 PIK38075.1 - 0.02 14.6 0.1 0.053 13.3 0.1 1.6 1 0 0 1 1 1 0 NHR2 domain like DUF2525 PF10733.9 PIK38075.1 - 0.2 12.0 1.0 2.5 8.5 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2525) SSB PF00436.25 PIK38076.1 - 0.16 12.0 0.0 1.1 9.3 0.0 1.9 2 0 0 2 2 2 0 Single-strand binding protein family Met_10 PF02475.16 PIK38077.1 - 1.1e-31 110.1 0.0 2.2e-31 109.2 0.0 1.5 2 0 0 2 2 2 1 Met-10+ like-protein MTS PF05175.14 PIK38077.1 - 0.00014 21.5 0.0 0.00029 20.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 PIK38077.1 - 0.00082 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DNA_methylase PF00145.17 PIK38077.1 - 0.0074 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Methyltransf_18 PF12847.7 PIK38077.1 - 0.0078 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK38077.1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.16 PIK38077.1 - 0.042 13.0 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_15 PF09445.10 PIK38077.1 - 0.042 13.4 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 PIK38077.1 - 0.062 14.0 0.0 0.17 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain DnaJ PF00226.31 PIK38078.1 - 1.5e-25 89.1 0.7 2.1e-25 88.6 0.7 1.2 1 0 0 1 1 1 1 DnaJ domain SSB PF00436.25 PIK38079.1 - 0.14 12.2 0.0 1.1 9.4 0.0 1.9 2 0 0 2 2 2 0 Single-strand binding protein family RVT_1 PF00078.27 PIK38080.1 - 5.8e-42 143.7 0.4 9.2e-42 143.0 0.4 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK38081.1 - 3e-07 30.2 0.0 3.3e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CD20 PF04103.15 PIK38083.1 - 6.4e-09 36.1 10.4 6.4e-09 36.1 10.4 2.0 1 1 1 2 2 2 1 CD20-like family DUF2427 PF10348.9 PIK38083.1 - 0.0013 18.5 2.0 0.0026 17.5 2.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) Ost5 PF05251.12 PIK38083.1 - 0.021 15.0 4.0 0.057 13.7 1.0 2.6 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 MARVEL PF01284.23 PIK38083.1 - 0.21 11.6 9.5 4.9 7.2 0.2 2.2 1 1 1 2 2 2 0 Membrane-associating domain DUF2754 PF10953.8 PIK38083.1 - 0.24 11.7 1.6 0.57 10.5 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) DUF89 PF01937.19 PIK38084.1 - 1.1e-114 383.1 0.1 1.3e-114 382.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Acetyltransf_1 PF00583.25 PIK38085.1 - 2e-14 53.8 0.1 2.8e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK38085.1 - 6.1e-10 39.4 0.2 1.1e-09 38.6 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 PIK38085.1 - 4.1e-09 36.5 0.0 6.1e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 PIK38085.1 - 7.7e-07 29.4 0.0 1.1e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 PIK38085.1 - 4.8e-05 23.4 0.0 0.0001 22.3 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 PIK38085.1 - 0.00014 22.0 0.1 0.00024 21.2 0.1 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 PIK38085.1 - 0.00029 20.8 0.0 0.0027 17.6 0.0 2.1 2 0 0 2 2 2 1 FR47-like protein PRIMA1 PF16101.5 PIK38085.1 - 0.04 14.0 6.8 0.099 12.7 6.8 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DAN PF03045.15 PIK38085.1 - 0.077 13.0 0.2 0.19 11.8 0.1 1.8 2 0 0 2 2 2 0 DAN domain CCDC92 PF14916.6 PIK38085.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain of unknown function CAP_N PF01213.19 PIK38085.1 - 0.24 10.8 4.7 0.36 10.3 4.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 PIK38085.1 - 0.31 11.1 4.5 0.49 10.4 4.5 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Phage_int_SAM_4 PF13495.6 PIK38087.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK38087.1 - 0.03 14.6 1.5 0.042 14.1 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Dam PF05869.11 PIK38088.1 - 0.19 11.2 0.1 0.38 10.3 0.1 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Sema PF01403.19 PIK38089.1 - 1.4e-37 129.6 1.5 2.3e-37 128.8 1.5 1.3 1 0 0 1 1 1 1 Sema domain TIG_plexin PF17960.1 PIK38089.1 - 1.4e-17 63.5 2.0 2.9e-16 59.2 0.2 2.8 2 0 0 2 2 2 1 TIG domain TIG PF01833.24 PIK38089.1 - 4.2e-17 62.0 15.4 2.6e-10 40.2 0.8 5.0 5 0 0 5 5 5 3 IPT/TIG domain TIG_2 PF18020.1 PIK38089.1 - 7.6e-12 45.7 1.5 9.5e-11 42.2 0.4 2.8 2 0 0 2 2 2 1 TIG domain found in plexin PSI PF01437.25 PIK38089.1 - 2.9e-07 30.9 11.0 2.9e-07 30.9 11.0 4.6 4 0 0 4 4 4 3 Plexin repeat Runt PF00853.19 PIK38089.1 - 0.12 11.9 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 Runt domain Plexin_cytopl PF08337.12 PIK38090.1 - 1.2e-127 427.0 0.2 1.5e-127 426.6 0.2 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain TIG PF01833.24 PIK38090.1 - 1.3e-25 89.3 3.6 1.5e-09 37.8 0.8 3.8 3 0 0 3 3 3 3 IPT/TIG domain TIG_2 PF18020.1 PIK38090.1 - 1.2e-10 41.8 1.1 4.2e-10 40.1 1.1 2.0 1 0 0 1 1 1 1 TIG domain found in plexin PSI PF01437.25 PIK38090.1 - 0.097 13.2 9.1 0.21 12.2 9.1 1.6 1 0 0 1 1 1 0 Plexin repeat RVT_1 PF00078.27 PIK38091.1 - 1.7e-10 40.8 0.4 3.3e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK38093.1 - 2.4e-10 40.1 0.1 5.3e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 SCAN domain rve PF00665.26 PIK38094.1 - 6.6e-16 58.6 0.0 7.9e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK38094.1 - 0.0012 18.6 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Secretin_N PF03958.17 PIK38094.1 - 0.13 12.7 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain RVT_1 PF00078.27 PIK38095.1 - 0.006 16.1 0.2 0.014 15.0 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_25 PF13481.6 PIK38097.1 - 0.00043 19.9 0.0 0.00093 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DED PF01335.21 PIK38097.1 - 0.0059 16.9 0.1 0.015 15.6 0.1 1.7 1 1 0 1 1 1 1 Death effector domain NACHT PF05729.12 PIK38097.1 - 0.0079 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain ATPase PF06745.13 PIK38097.1 - 0.032 13.6 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 KaiC TsaE PF02367.17 PIK38097.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Transthyretin PF00576.21 PIK38100.1 - 0.032 14.9 0.0 0.054 14.2 0.0 1.4 1 1 1 2 2 2 0 HIUase/Transthyretin family RNA_pol_Rpb2_6 PF00562.28 PIK38101.1 - 2.5e-19 69.6 0.0 2.7e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_6 PF00562.28 PIK38102.1 - 1.1e-42 146.5 0.0 1.6e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_4 PF04566.13 PIK38102.1 - 1.3e-29 102.2 0.8 2.7e-29 101.2 0.8 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 PIK38102.1 - 1.7e-21 76.1 0.1 4.2e-21 74.9 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 PIK38102.1 - 4.6e-09 36.7 3.7 2.5e-08 34.3 3.7 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Cpn60_TCP1 PF00118.24 PIK38103.1 - 1e-08 34.3 0.0 1e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RNase_II_C_S1 PF18614.1 PIK38103.1 - 0.044 13.7 0.3 0.069 13.1 0.3 1.3 1 0 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain Cpn60_TCP1 PF00118.24 PIK38104.1 - 2.9e-43 148.2 1.0 3.7e-43 147.9 1.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3155 PF11352.8 PIK38105.1 - 0.0029 18.0 2.1 42 4.6 0.0 6.0 7 0 0 7 7 7 0 Protein of unknown function (DUF3155) WD40 PF00400.32 PIK38105.1 - 0.053 14.4 8.5 0.67 10.9 0.4 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat PyrI_C PF02748.15 PIK38105.1 - 0.072 13.0 5.1 0.15 12.0 2.0 2.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_8 PF15909.5 PIK38105.1 - 0.16 12.3 1.5 0.41 11.0 1.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2 PF00096.26 PIK38105.1 - 0.42 11.2 12.2 9.9 6.8 7.8 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK38105.1 - 0.66 11.0 19.9 0.081 13.8 8.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger FGE-sulfatase PF03781.16 PIK38106.1 - 0.17 11.4 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 PHO4 PF01384.20 PIK38107.1 - 8.4e-38 130.3 1.4 1e-37 130.0 1.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family RVT_1 PF00078.27 PIK38108.1 - 0.0074 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ArAE_2 PF10334.9 PIK38110.1 - 7.6e-05 22.6 0.1 0.00014 21.8 0.1 1.3 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 Kelch_2 PF07646.15 PIK38110.1 - 0.16 12.0 0.6 1.3 9.1 0.0 2.9 3 1 0 3 3 3 0 Kelch motif Scm3 PF10384.9 PIK38110.1 - 0.2 11.4 0.1 0.2 11.4 0.1 2.6 3 0 0 3 3 3 0 Centromere protein Scm3 Baculo_PEP_C PF04513.12 PIK38110.1 - 1.4 8.9 4.4 0.47 10.5 1.1 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-B_box PF00643.24 PIK38110.1 - 4.2 7.6 10.6 28 5.0 10.6 2.5 1 1 0 1 1 1 0 B-box zinc finger Filament PF00038.21 PIK38111.1 - 0.00022 20.9 3.5 0.0003 20.5 3.5 1.3 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 PIK38111.1 - 0.00054 19.0 8.2 0.0008 18.4 8.2 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Bap31_Bap29_C PF18035.1 PIK38111.1 - 0.00055 19.9 4.5 0.00055 19.9 4.5 1.9 2 1 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Baculo_PEP_C PF04513.12 PIK38111.1 - 0.0046 17.0 3.4 0.045 13.8 1.6 2.3 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus COG5 PF10392.9 PIK38111.1 - 0.0079 16.4 1.6 0.014 15.6 1.6 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 FapA PF03961.13 PIK38111.1 - 0.02 13.6 5.6 0.026 13.2 5.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 PIK38111.1 - 0.023 15.0 6.7 0.033 14.5 6.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TolA_bind_tri PF16331.5 PIK38111.1 - 0.025 14.7 5.4 0.033 14.3 0.9 2.3 1 1 1 2 2 2 0 TolA binding protein trimerisation CENP-K PF11802.8 PIK38111.1 - 0.029 13.9 5.2 0.038 13.6 5.2 1.1 1 0 0 1 1 1 0 Centromere-associated protein K DUF848 PF05852.11 PIK38111.1 - 0.13 12.4 4.1 0.06 13.5 2.1 1.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) SKA2 PF16740.5 PIK38111.1 - 0.14 12.0 5.6 0.25 11.1 1.3 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Lant_dehydr_C PF14028.6 PIK38111.1 - 0.18 11.3 0.3 0.24 10.9 0.3 1.1 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Spc24 PF08286.11 PIK38111.1 - 3.8 7.8 11.3 15 5.9 11.3 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 RVT_1 PF00078.27 PIK38112.1 - 2.1e-07 30.7 0.2 2.9e-05 23.7 0.2 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RING_UBOX PF13445.6 PIK38113.1 - 7.8e-10 38.6 6.3 7.8e-10 38.6 6.3 3.3 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK38113.1 - 7.9e-09 35.3 8.7 7.9e-09 35.3 8.7 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK38113.1 - 5.6e-06 26.1 10.0 5.6e-06 26.1 10.0 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK38113.1 - 5.7e-06 26.6 7.5 5.7e-06 26.6 7.5 3.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK38113.1 - 1e-05 25.2 11.5 1e-05 25.2 11.5 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK38113.1 - 1.5e-05 25.0 9.3 1.5e-05 25.0 9.3 4.1 3 2 1 4 4 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK38113.1 - 4.8e-05 23.2 7.4 4.8e-05 23.2 7.4 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK38113.1 - 0.0002 21.5 28.0 0.0014 18.7 12.4 4.3 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK38113.1 - 0.015 15.2 11.1 0.015 15.2 11.1 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 ERCC4 PF02732.15 PIK38113.1 - 0.076 13.2 0.8 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 ERCC4 domain DapB_C PF05173.14 PIK38113.1 - 0.17 12.0 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus MRNIP PF15749.5 PIK38114.1 - 2.1e-06 28.4 0.0 2.1e-06 28.4 0.0 3.4 3 1 0 3 3 3 1 MRN-interacting protein WD40 PF00400.32 PIK38115.1 - 9e-30 102.3 31.8 0.0015 19.3 0.7 12.2 12 0 0 12 12 12 8 WD domain, G-beta repeat DUF667 PF05018.13 PIK38115.1 - 1.2e-27 96.8 0.4 5.8e-20 71.8 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF667) ANAPC4_WD40 PF12894.7 PIK38115.1 - 2.6e-13 50.1 0.0 0.22 11.9 0.0 7.0 5 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 PIK38115.1 - 6.5e-06 25.9 0.0 0.0077 16.1 0.0 2.6 2 0 0 2 2 2 2 HELP motif M64_N PF16217.5 PIK38115.1 - 0.059 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase M64 N-terminus Mito_carr PF00153.27 PIK38116.1 - 3.5e-22 78.1 0.0 4.8e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein BCD PF15461.6 PIK38116.1 - 0.063 12.8 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase adh_short PF00106.25 PIK38117.1 - 6.4e-37 126.9 0.0 1.7e-36 125.6 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38117.1 - 5.9e-25 88.2 0.0 1.2e-24 87.1 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38117.1 - 4.4e-10 39.8 0.0 6.7e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 PIK38117.1 - 0.00069 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK38117.1 - 0.00081 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK38117.1 - 0.0046 16.0 0.1 0.0062 15.6 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 PIK38117.1 - 0.0065 15.6 0.0 0.0088 15.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein rve PF00665.26 PIK38118.1 - 2e-07 31.2 0.0 2.7e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain adh_short PF00106.25 PIK38119.1 - 5.9e-37 127.0 0.0 7.7e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38119.1 - 3e-25 89.1 0.4 8.8e-25 87.6 0.4 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38119.1 - 2.8e-08 33.9 0.0 5.6e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK38119.1 - 5.2e-06 25.8 0.0 7.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK38119.1 - 1.7e-05 24.4 0.1 0.00025 20.6 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK38119.1 - 0.01 15.3 0.1 0.018 14.4 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 PIK38119.1 - 0.14 12.0 0.1 0.35 10.7 0.0 1.6 1 1 1 2 2 2 0 NAD(P)H-binding DAO PF01266.24 PIK38120.1 - 3.2e-26 92.8 0.0 6.3e-26 91.8 0.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK38120.1 - 1.9e-05 24.1 0.1 0.0015 17.8 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK38120.1 - 0.00011 22.3 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK38120.1 - 0.0002 20.7 0.0 0.16 11.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK38120.1 - 0.0011 18.1 0.0 0.0022 17.2 0.0 1.4 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 PIK38120.1 - 0.0083 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK38120.1 - 0.0095 15.1 0.0 0.03 13.4 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 PIK38120.1 - 0.024 13.3 0.0 0.28 9.8 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein ApbA PF02558.16 PIK38120.1 - 0.04 13.6 0.2 0.44 10.2 0.1 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 PIK38120.1 - 0.057 12.7 0.0 0.085 12.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 PIK38120.1 - 0.11 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 PIK38120.1 - 0.13 12.9 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RVT_1 PF00078.27 PIK38121.1 - 5.7e-15 55.4 0.0 4.6e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK38121.1 - 2e-06 28.0 0.1 1e-05 25.8 0.1 2.1 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK38121.1 - 0.00079 19.2 0.1 0.0015 18.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK38121.1 - 0.0095 16.0 0.0 0.049 13.7 0.0 2.1 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4704 PF15787.5 PIK38121.1 - 0.044 13.0 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4704) Raftlin PF15250.6 PIK38122.1 - 0.36 9.5 0.0 0.36 9.5 0.0 2.7 2 1 0 3 3 3 0 Raftlin YebO PF13974.6 PIK38123.1 - 0.033 14.3 1.7 0.061 13.4 1.7 1.4 1 0 0 1 1 1 0 YebO-like protein Vpu PF00558.19 PIK38123.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Vpu protein TERB2 PF15101.6 PIK38124.1 - 0.061 13.4 3.9 0.073 13.1 3.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4518 PF15008.6 PIK38124.1 - 1.7 7.8 5.0 0.81 8.8 3.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) TFIIA PF03153.13 PIK38124.1 - 3.9 7.4 18.9 4.4 7.2 18.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAS_11 PF14598.6 PIK38125.1 - 1.7e-23 82.9 0.2 5.7e-23 81.2 0.0 2.0 3 0 0 3 3 3 1 PAS domain PAS_3 PF08447.12 PIK38125.1 - 2.4e-19 69.4 0.1 1.5e-17 63.7 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 PIK38125.1 - 6.2e-11 42.3 0.0 7.8e-08 32.3 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK38125.1 - 1e-07 32.1 0.0 1.9e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 PIK38125.1 - 0.0003 21.0 0.0 0.00084 19.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold HLH PF00010.26 PIK38126.1 - 2.1e-14 53.2 1.1 2.1e-14 53.2 1.1 1.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3776 PF12618.8 PIK38126.1 - 0.00065 20.2 0.5 0.00093 19.7 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3776) PAS PF00989.25 PIK38126.1 - 0.006 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold APH PF01636.23 PIK38127.1 - 1.4e-18 67.7 0.0 3e-13 50.2 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family A_deaminase PF00962.22 PIK38128.1 - 5.8e-24 85.0 0.0 7.1e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Pkinase PF00069.25 PIK38129.1 - 1e-46 159.5 0.0 1.1e-34 120.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38129.1 - 1.7e-26 93.1 0.0 1.8e-20 73.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PB1 PF00564.24 PIK38129.1 - 7.7e-10 38.6 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain Pkinase_fungal PF17667.1 PIK38129.1 - 0.00022 20.2 0.0 0.00033 19.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK38129.1 - 0.027 13.4 0.1 0.11 11.4 0.1 1.9 1 1 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 PIK38129.1 - 0.028 13.7 0.0 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 PIK38129.1 - 0.056 13.4 0.0 2.8 7.8 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family BUD22 PF09073.10 PIK38130.1 - 0.0017 17.8 0.2 0.0018 17.7 0.2 1.0 1 0 0 1 1 1 1 BUD22 PPR_2 PF13041.6 PIK38130.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 PPR repeat family DUF3987 PF13148.6 PIK38130.1 - 0.13 11.2 0.2 0.15 11.1 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) PHD PF00628.29 PIK38131.1 - 1.2e-08 34.7 11.5 2.2e-08 33.9 11.5 1.5 1 0 0 1 1 1 1 PHD-finger DDE_1 PF03184.19 PIK38131.1 - 2.2e-07 30.7 0.0 5.5e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease C1_1 PF00130.22 PIK38131.1 - 0.00056 19.7 1.4 0.00056 19.7 1.4 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DDE_3 PF13358.6 PIK38131.1 - 0.012 15.4 0.2 0.12 12.1 0.0 2.6 3 0 0 3 3 3 0 DDE superfamily endonuclease Prok-RING_1 PF14446.6 PIK38131.1 - 0.013 15.5 1.7 0.025 14.5 1.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 MgsA_C PF12002.8 PIK38131.1 - 0.033 14.1 0.6 0.14 12.1 0.4 2.1 2 0 0 2 2 2 0 MgsA AAA+ ATPase C terminal Zf_RING PF16744.5 PIK38131.1 - 0.14 12.2 7.6 0.41 10.8 7.6 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 PIK38131.1 - 0.67 10.2 5.2 1.6 9.0 5.2 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain Metallophos PF00149.28 PIK38132.1 - 2.5e-20 73.8 1.7 3.4e-20 73.4 1.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK38132.1 - 0.0002 21.6 0.1 0.018 15.3 0.1 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 PIK38132.1 - 0.028 13.4 0.0 3.7 6.5 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase DEAD_2 PF06733.15 PIK38133.1 - 5.9e-52 175.8 0.0 1.3e-51 174.7 0.0 1.6 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 PIK38133.1 - 2e-46 158.1 0.5 1.9e-42 145.1 0.1 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 PIK38133.1 - 5.2e-45 153.7 0.0 1.3e-44 152.4 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 PIK38133.1 - 3.4e-06 27.2 0.0 0.0045 17.0 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK38133.1 - 0.0013 18.5 0.1 2 8.1 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase UvrD-helicase PF00580.21 PIK38133.1 - 0.026 14.1 0.7 12 5.3 0.0 3.0 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Myb_DNA-bind_4 PF13837.6 PIK38133.1 - 0.12 12.7 0.4 1.8 9.0 0.0 2.8 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain DnaB_2 PF07261.11 PIK38133.1 - 0.14 11.9 0.0 0.93 9.3 0.0 2.4 2 0 0 2 2 2 0 Replication initiation and membrane attachment SAA PF00277.18 PIK38135.1 - 1.5e-44 150.6 8.2 1.7e-44 150.4 8.2 1.0 1 0 0 1 1 1 1 Serum amyloid A protein Tubulin_C PF03953.17 PIK38136.1 - 9.6e-34 116.3 0.0 1.3e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 PIK38137.1 - 1.4e-68 231.0 0.0 1.6e-68 230.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 PIK38137.1 - 0.00053 19.7 0.0 0.00076 19.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain DUF4078 PF13300.6 PIK38139.1 - 2.7e-24 85.3 8.5 2.7e-24 85.3 8.5 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DDE_Tnp_IS1595 PF12762.7 PIK38139.1 - 8.4e-22 77.8 0.0 1.9e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 ISXO2-like transposase domain Poty_PP PF08440.10 PIK38139.1 - 0.12 11.4 0.2 0.22 10.6 0.2 1.3 1 0 0 1 1 1 0 Potyviridae polyprotein G6PD_C PF02781.16 PIK38140.1 - 2.2e-60 204.3 0.0 3.5e-60 203.7 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 PIK38140.1 - 4.2e-35 122.0 0.0 1.1e-34 120.6 0.0 1.7 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glucosamine_iso PF01182.20 PIK38140.1 - 2.5e-28 99.5 0.0 4.2e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Isochorismatase PF00857.20 PIK38141.1 - 2.4e-31 109.2 0.0 3.8e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family Aldedh PF00171.22 PIK38142.1 - 1.4e-66 225.0 0.0 1.7e-33 115.8 0.0 3.0 3 0 0 3 3 3 3 Aldehyde dehydrogenase family DRTGG PF07085.12 PIK38142.1 - 0.096 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DRTGG domain 7tm_1 PF00001.21 PIK38143.1 - 3.2e-17 62.7 24.8 3.8e-17 62.5 24.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pneumo_att_G PF05539.11 PIK38143.1 - 0.3 10.7 1.1 0.45 10.1 1.1 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Aldedh PF00171.22 PIK38144.1 - 0.0027 16.3 0.0 0.003 16.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tubulin PF00091.25 PIK38145.1 - 6.5e-26 91.7 0.0 7.8e-26 91.5 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 PIK38145.1 - 4.9e-06 26.8 0.0 8e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_C PF03953.17 PIK38146.1 - 2.7e-43 147.1 0.1 4.5e-43 146.4 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 PIK38146.1 - 6.5e-15 55.9 0.1 1.3e-14 54.8 0.1 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain RbsD_FucU PF05025.13 PIK38147.1 - 1.8e-28 99.7 0.0 2.1e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family RVT_1 PF00078.27 PIK38148.1 - 3.5e-31 108.4 0.2 6.1e-31 107.7 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK38148.1 - 2.8e-22 78.6 0.0 7.3e-22 77.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38148.1 - 1.7e-09 37.9 0.0 4.3e-09 36.6 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Serinc PF03348.15 PIK38151.1 - 2.7 6.8 9.3 0.083 11.8 0.7 2.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) RSB_motif PF16294.5 PIK38151.1 - 6.8 7.0 21.6 4.5 7.6 7.3 2.3 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif RVT_1 PF00078.27 PIK38153.1 - 7.3e-30 104.1 0.1 1.9e-29 102.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK38153.1 - 0.032 14.1 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Med18 protein YL1 PF05764.13 PIK38154.1 - 0.00045 20.4 12.0 0.00058 20.0 12.0 1.1 1 0 0 1 1 1 1 YL1 nuclear protein eIF-3c_N PF05470.12 PIK38154.1 - 0.0088 14.4 6.2 0.0099 14.2 6.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Spt5_N PF11942.8 PIK38154.1 - 0.037 15.0 10.9 0.059 14.4 10.9 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal GAGA_bind PF06217.12 PIK38154.1 - 0.038 14.3 5.1 0.043 14.1 5.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Intein_splicing PF14890.6 PIK38154.1 - 0.2 11.6 3.5 0.14 12.1 2.0 1.5 1 1 0 1 1 1 0 Intein splicing domain CDC45 PF02724.14 PIK38154.1 - 0.46 8.7 11.3 0.52 8.5 11.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3535 PF12054.8 PIK38155.1 - 8.6e-73 246.0 0.5 4.5e-72 243.7 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 PIK38155.1 - 3.4e-53 180.6 3.3 1.5e-38 132.5 0.1 3.5 2 1 2 4 4 4 2 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK38155.1 - 1.3e-17 64.1 0.0 3.5e-17 62.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 PIK38155.1 - 4.4e-08 32.7 0.6 0.0013 18.8 0.1 3.4 2 0 0 2 2 2 2 HEAT repeat ResIII PF04851.15 PIK38155.1 - 7.6e-06 26.0 0.0 2.7e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HEAT_EZ PF13513.6 PIK38155.1 - 5.6e-05 23.5 2.0 0.31 11.6 0.1 4.4 3 1 1 4 4 4 2 HEAT-like repeat Arm PF00514.23 PIK38155.1 - 6.9e-05 22.8 0.1 0.96 9.6 0.0 3.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat DEAD PF00270.29 PIK38155.1 - 0.00058 19.7 0.0 0.0026 17.5 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Cnd1 PF12717.7 PIK38155.1 - 0.0052 16.8 0.3 11 6.0 0.0 3.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 PhoH PF02562.16 PIK38155.1 - 0.011 15.2 0.0 0.17 11.3 0.0 2.6 3 0 0 3 3 3 0 PhoH-like protein CLASP_N PF12348.8 PIK38155.1 - 0.028 14.0 0.1 0.095 12.2 0.1 1.9 1 1 0 1 1 1 0 CLASP N terminal NUC173 PF08161.12 PIK38155.1 - 0.043 13.5 0.4 1.2 8.8 0.0 3.2 4 0 0 4 4 4 0 NUC173 domain HEAT PF02985.22 PIK38156.1 - 2.9e-11 42.6 4.4 0.045 14.0 0.1 6.0 5 1 1 6 6 6 4 HEAT repeat DUF3535 PF12054.8 PIK38156.1 - 5.7e-10 39.0 0.0 1.8e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) HEAT_EZ PF13513.6 PIK38156.1 - 4.2e-05 23.9 1.5 0.22 12.1 0.1 4.4 5 0 0 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK38156.1 - 6.4e-05 23.5 0.0 0.00036 21.1 0.0 2.1 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 PIK38156.1 - 0.0011 19.4 0.4 7.7 7.0 0.1 3.9 2 1 0 3 3 3 1 HEAT repeats NanE PF04131.14 PIK38156.1 - 0.076 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase MMS19_C PF12460.8 PIK38156.1 - 0.1 11.7 1.6 5.5 6.0 0.3 2.4 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal CAP PF00188.26 PIK38157.1 - 2.5e-17 63.9 2.1 3.6e-17 63.4 2.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family UQ_con PF00179.26 PIK38158.1 - 9.7e-35 119.2 0.0 1.3e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK38158.1 - 0.01 15.6 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B AAA_6 PF12774.7 PIK38159.1 - 2.1e-159 529.8 0.0 6.7e-158 524.9 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK38159.1 - 1.8e-150 501.5 7.2 1.8e-150 501.5 7.2 3.2 3 0 0 3 3 2 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 PIK38159.1 - 1.1e-121 405.8 0.0 3.4e-121 404.2 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 PIK38159.1 - 2.7e-108 361.2 1.6 1.1e-107 359.3 0.9 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK38159.1 - 4.4e-91 303.9 1.8 4.4e-91 303.9 1.8 3.3 4 0 0 4 4 4 1 ATP-binding dynein motor region AAA_7 PF12775.7 PIK38159.1 - 5.8e-83 276.9 0.5 1e-80 269.5 0.0 3.7 3 1 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 PIK38159.1 - 3e-54 183.2 0.0 9.1e-54 181.7 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK38159.1 - 2e-49 166.6 0.0 6.8e-46 155.2 0.0 3.3 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK38159.1 - 7.9e-43 146.8 7.4 7.9e-43 146.8 7.4 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 PIK38159.1 - 5.6e-39 133.2 0.5 7.7e-38 129.5 0.2 3.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK38159.1 - 2.5e-19 69.6 0.0 1.1e-05 25.5 0.0 5.9 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 PIK38159.1 - 1e-18 67.3 3.5 1.7e-18 66.6 0.7 3.0 3 0 0 3 3 2 1 AAA+ lid domain AAA PF00004.29 PIK38159.1 - 5e-05 23.7 0.2 0.97 9.9 0.0 4.1 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK38159.1 - 0.00028 21.2 0.1 0.12 12.6 0.0 3.9 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 PIK38159.1 - 0.0031 17.9 0.7 3.7 8.0 0.0 4.3 5 0 0 5 5 2 1 RNA helicase AAA_16 PF13191.6 PIK38159.1 - 0.0031 17.9 0.0 2.2 8.6 0.0 3.5 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 PIK38159.1 - 0.008 15.3 0.0 0.022 13.8 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_18 PF13238.6 PIK38159.1 - 0.022 15.3 0.3 3.4 8.2 0.0 4.3 4 0 0 4 4 3 0 AAA domain AAA_30 PF13604.6 PIK38159.1 - 0.066 12.9 1.3 4.5 6.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 PIK38159.1 - 0.097 12.4 0.1 0.87 9.3 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain Peptidase_S66C PF17676.1 PIK38159.1 - 0.14 12.7 0.0 0.51 10.9 0.0 2.0 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain PhoH PF02562.16 PIK38159.1 - 0.48 9.8 1.9 5.5 6.4 0.0 3.1 3 0 0 3 3 3 0 PhoH-like protein LemA PF04011.12 PIK38159.1 - 9.8 6.0 7.3 1.6 8.6 0.5 2.8 2 0 0 2 2 2 0 LemA family Cu2_monoox_C PF03712.15 PIK38161.1 - 5.1e-31 107.3 0.3 1.1e-22 80.3 0.0 2.7 2 2 2 4 4 4 2 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 PIK38161.1 - 3.2e-30 105.0 0.3 5.7e-30 104.2 0.3 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Dimer_Tnp_hAT PF05699.14 PIK38162.1 - 0.00063 19.5 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DFF-C PF09033.10 PIK38163.1 - 1.7e-08 34.5 2.0 3e-07 30.5 0.1 2.1 1 1 0 2 2 2 2 DNA Fragmentation factor 45kDa, C terminal domain PH PF00169.29 PIK38164.1 - 5.3e-07 30.1 0.0 7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 PH domain DUF3694 PF12473.8 PIK38165.1 - 2.3e-37 129.1 0.0 1.2e-36 126.6 0.0 2.2 2 0 0 2 2 2 1 Kinesin protein KIF1B PF12423.8 PIK38165.1 - 1.6e-11 44.5 0.0 4.6e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein 1B Kinesin PF00225.23 PIK38166.1 - 7.7e-113 376.8 0.4 1e-112 376.4 0.4 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 PIK38166.1 - 5.1e-59 199.4 9.3 3.9e-49 167.2 0.4 3.3 2 1 1 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 PIK38166.1 - 2.6e-23 82.6 0.1 6.5e-23 81.3 0.1 1.8 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.26 PIK38166.1 - 3.4e-06 27.3 0.0 3.2e-05 24.2 0.0 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 PIK38166.1 - 0.0012 19.1 0.0 0.0051 17.1 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain EF-hand_1 PF00036.32 PIK38166.1 - 0.074 12.6 0.6 0.21 11.2 0.2 2.0 2 0 0 2 2 2 0 EF hand AAA_22 PF13401.6 PIK38166.1 - 0.084 13.2 0.1 9.7 6.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain EF-hand_5 PF13202.6 PIK38166.1 - 0.1 12.1 0.3 0.27 10.8 0.3 1.8 1 0 0 1 1 1 0 EF hand G-gamma PF00631.22 PIK38166.1 - 3.1 7.9 6.4 0.79 9.8 0.2 3.0 3 0 0 3 3 3 0 GGL domain Methyltr_RsmB-F PF01189.17 PIK38167.1 - 1e-29 103.6 0.0 1.9e-29 102.8 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 PIK38167.1 - 0.0013 18.9 0.0 0.0032 17.6 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase NUC153 PF08159.12 PIK38167.1 - 0.078 12.8 0.1 1.9 8.4 0.1 2.6 2 0 0 2 2 2 0 NUC153 domain SRCR PF00530.18 PIK38168.1 - 2e-189 615.5 54.4 5.1e-30 103.9 1.9 7.0 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38168.1 - 1.5e-42 144.1 17.2 1.1e-05 25.9 0.3 7.4 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK38168.1 - 1.3e-20 73.9 0.1 0.14 12.7 0.0 7.3 6 1 1 7 7 7 7 Hepsin, SRCR domain YecR PF13992.6 PIK38168.1 - 4.3e-08 33.3 17.9 0.81 10.0 0.2 6.9 7 0 0 7 7 7 5 YecR-like lipoprotein Peptidase_C107 PF17222.3 PIK38168.1 - 0.0016 17.5 3.6 17 4.3 0.0 5.1 6 0 0 6 6 6 3 Viral cysteine endopeptidase C107 SRCR PF00530.18 PIK38169.1 - 0 1417.5 146.9 4.6e-29 100.9 2.9 16.0 16 0 0 16 16 16 16 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38169.1 - 9.5e-94 308.3 57.5 8.2e-05 23.1 0.1 16.6 16 0 0 16 16 16 16 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK38169.1 - 2.5e-40 137.4 20.3 0.9 10.1 0.1 16.3 16 0 0 16 16 16 15 Hepsin, SRCR domain YecR PF13992.6 PIK38169.1 - 2.2e-20 72.7 59.9 0.88 9.9 0.2 16.2 16 0 0 16 16 16 11 YecR-like lipoprotein DUF4995 PF16386.5 PIK38169.1 - 1.7e-07 31.1 36.1 4 7.5 0.1 13.8 15 0 0 15 15 15 4 Domain of unknown function DUF3652 PF12372.8 PIK38169.1 - 0.00018 21.3 0.1 56 3.7 0.0 7.0 8 0 0 8 8 8 0 Huntingtin protein region DEAD_assoc PF08494.11 PIK38169.1 - 0.02 14.7 0.0 1.5e+02 2.0 0.0 6.1 10 0 0 10 10 10 0 DEAD/H associated DUF4160 PF13711.6 PIK38169.1 - 2 8.8 4.4 2.3e+03 -1.0 0.0 7.4 13 0 0 13 13 13 0 Domain of unknown function (DUF4160) SRCR PF00530.18 PIK38170.1 - 1.2e-29 102.8 3.1 1.3e-29 102.6 3.1 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38170.1 - 2.8e-06 27.8 0.5 4.6e-06 27.1 0.2 1.5 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK38170.1 - 0.023 15.2 0.1 0.031 14.8 0.1 1.2 1 1 0 1 1 1 0 Hepsin, SRCR domain YecR PF13992.6 PIK38170.1 - 0.26 11.6 2.1 0.26 11.6 1.4 1.6 1 1 0 1 1 1 0 YecR-like lipoprotein Tubulin PF00091.25 PIK38171.1 - 2.2e-67 227.1 0.0 3.2e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK38171.1 - 1.3e-11 44.7 0.1 3.6e-11 43.3 0.1 1.8 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK38171.1 - 0.0008 19.1 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain SRCR PF00530.18 PIK38172.1 - 3.5e-44 149.4 5.0 1.9e-20 73.2 2.2 3.6 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38172.1 - 7e-11 42.5 2.7 8.1e-07 29.5 0.2 2.8 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK38172.1 - 0.00011 22.7 1.7 0.019 15.5 0.1 2.6 2 0 0 2 2 2 2 Hepsin, SRCR domain Sushi PF00084.20 PIK38172.1 - 0.0024 18.4 15.2 0.53 10.9 1.4 4.1 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) S1FA PF04689.13 PIK38172.1 - 0.053 13.7 0.5 0.13 12.5 0.4 1.6 1 1 1 2 2 2 0 DNA binding protein S1FA FtsL PF04999.13 PIK38172.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Cell division protein FtsL Saf_2TM PF18303.1 PIK38172.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Ras PF00071.22 PIK38173.1 - 2.5e-17 63.0 0.0 7.4e-17 61.4 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK38173.1 - 1.6e-16 60.6 0.0 1.3e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK38173.1 - 1.8e-07 30.8 0.0 5.8e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family IIGP PF05049.13 PIK38173.1 - 0.00037 19.7 0.1 0.00063 18.9 0.1 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 PIK38173.1 - 0.0018 18.3 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK38173.1 - 0.019 15.3 0.1 0.044 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Gtr1_RagA PF04670.12 PIK38173.1 - 0.023 14.1 0.0 0.054 12.9 0.0 1.6 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 PIK38173.1 - 0.058 13.3 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase MCM PF00493.23 PIK38173.1 - 0.065 12.3 0.0 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain AAA_29 PF13555.6 PIK38173.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DnaJ_C PF01556.18 PIK38174.1 - 3.4e-41 140.8 0.0 4.5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 PIK38174.1 - 5.2e-22 77.7 1.0 7.8e-22 77.2 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain ASH PF15780.5 PIK38175.1 - 3.7e-15 55.9 11.3 0.059 13.6 0.2 8.4 8 1 0 8 8 8 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 PIK38175.1 - 4.5e-14 52.2 4.1 0.0033 17.3 0.0 5.9 6 0 0 6 6 6 5 MSP (Major sperm protein) domain PapD-like PF14874.6 PIK38175.1 - 4.1e-11 42.9 6.2 0.015 15.5 0.0 6.0 7 0 0 7 7 7 3 Flagellar-associated PapD-like DUF1573 PF07610.11 PIK38175.1 - 1.6e-08 34.5 4.7 1.5 8.9 0.2 5.7 5 0 0 5 5 5 4 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 PIK38175.1 - 7.7e-06 26.1 8.5 0.007 16.6 0.1 5.2 5 0 0 5 5 5 2 Transmembrane protein 131-like Transglut_C PF00927.22 PIK38175.1 - 0.00099 19.2 0.2 4.4 7.5 0.1 4.2 3 0 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain DUF3673 PF12425.8 PIK38175.1 - 0.12 12.3 0.5 0.34 10.8 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) DNA_pol_A PF00476.20 PIK38175.1 - 0.16 11.0 0.6 3.5 6.6 0.3 2.7 3 1 0 3 3 3 0 DNA polymerase family A CH PF00307.31 PIK38177.1 - 1.4e-07 31.7 0.0 4.1e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 Calponin homology (CH) domain ASH PF15780.5 PIK38177.1 - 0.007 16.6 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin GlgX_C PF18390.1 PIK38177.1 - 0.035 13.9 0.2 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Glycogen debranching enzyme C-terminal domain CAMSAP_CH PF11971.8 PIK38177.1 - 0.059 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain WD40 PF00400.32 PIK38181.1 - 0.0068 17.2 0.0 0.017 15.9 0.0 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat UPF0154 PF03672.13 PIK38181.1 - 0.01 15.8 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) WD40 PF00400.32 PIK38182.1 - 4.9e-08 33.5 4.0 0.19 12.6 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38182.1 - 0.00012 22.3 0.0 0.00067 19.9 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK38182.1 - 0.078 12.8 0.0 2.6 7.9 0.0 2.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A NYD-SP28 PF14772.6 PIK38183.1 - 4.1e-23 81.3 6.3 4.1e-23 81.3 6.3 5.3 3 1 4 7 7 7 1 Sperm tail NYD-SP28_assoc PF14775.6 PIK38183.1 - 5e-08 32.9 14.5 7.9e-07 29.1 3.4 3.7 3 0 0 3 3 3 2 Sperm tail C-terminal domain DHH PF01368.20 PIK38183.1 - 0.061 13.6 0.1 0.19 12.0 0.1 1.8 1 0 0 1 1 1 0 DHH family DASH_Dad1 PF08649.10 PIK38183.1 - 1.1 9.6 11.3 1.8 8.8 0.1 4.1 5 0 0 5 5 5 0 DASH complex subunit Dad1 Synaptobrevin PF00957.21 PIK38183.1 - 4.1 7.3 8.0 1.1 9.1 3.0 2.6 2 0 0 2 2 2 0 Synaptobrevin Collagen PF01391.18 PIK38184.1 - 0.018 14.8 1.9 0.034 13.9 1.9 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK38185.1 - 0.012 15.3 2.0 0.032 14.0 2.0 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) DUF2730 PF10805.8 PIK38185.1 - 0.038 14.1 0.1 0.063 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) RWD PF05773.22 PIK38186.1 - 5e-16 59.0 0.5 1.2e-15 57.8 0.5 1.6 1 0 0 1 1 1 1 RWD domain zf-RING_5 PF14634.6 PIK38186.1 - 1e-06 28.6 8.8 1.9e-06 27.7 8.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK38186.1 - 2.6e-06 27.6 11.1 6.6e-06 26.4 11.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK38186.1 - 0.00011 22.0 8.3 0.00025 20.8 8.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 PIK38186.1 - 0.0044 16.8 0.4 0.22 11.4 0.1 3.0 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C3HC4_2 PF13923.6 PIK38186.1 - 0.0076 16.1 8.3 0.022 14.6 7.8 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 PIK38186.1 - 0.0099 15.9 2.1 0.02 14.9 2.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 PIK38186.1 - 0.01 16.1 8.7 0.17 12.2 8.9 2.5 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 PIK38186.1 - 0.078 12.8 9.3 0.17 11.8 9.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YbaB_DNA_bd PF02575.16 PIK38186.1 - 0.095 12.9 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 YbaB/EbfC DNA-binding family zf-RING_UBOX PF13445.6 PIK38186.1 - 0.11 12.6 7.0 0.39 10.8 1.8 2.6 2 1 0 2 2 2 0 RING-type zinc-finger DUF2175 PF09943.9 PIK38186.1 - 0.19 12.0 1.3 0.52 10.6 1.3 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_11 PF17123.5 PIK38186.1 - 0.22 11.3 12.1 0.061 13.1 8.7 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-Nse PF11789.8 PIK38186.1 - 0.42 10.5 7.0 1.2 9.0 7.0 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.11 PIK38186.1 - 1.1 9.6 8.5 2.3 8.6 8.5 1.6 1 0 0 1 1 1 0 RING-like domain Lipocalin PF00061.23 PIK38187.1 - 0.0031 17.7 0.1 0.0054 16.9 0.1 1.4 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK38187.1 - 0.11 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family WD40_4 PF16300.5 PIK38188.1 - 2.4e-18 65.8 0.0 4.8e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 PIK38188.1 - 4.6e-10 39.9 1.6 0.00023 21.9 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38188.1 - 5.6e-06 26.6 0.3 0.035 14.4 0.0 3.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain ASH PF15780.5 PIK38188.1 - 0.16 12.2 0.1 0.71 10.1 0.1 2.1 1 1 1 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Lectin_C PF00059.21 PIK38189.1 - 6.5e-10 39.7 0.4 1.1e-09 39.0 0.4 1.4 1 1 0 1 1 1 1 Lectin C-type domain Actin PF00022.19 PIK38190.1 - 1.9e-42 145.3 0.0 2.1e-25 89.2 0.0 2.0 1 1 1 2 2 2 2 Actin Peptidase_M28 PF04389.17 PIK38191.1 - 9.7e-08 31.9 0.0 1.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 PIK38191.1 - 0.00018 21.0 0.0 0.00032 20.2 0.0 1.4 1 0 0 1 1 1 1 Nicastrin THAP PF05485.12 PIK38192.1 - 1.2e-11 45.4 0.4 1.2e-11 45.4 0.4 2.1 2 0 0 2 2 2 1 THAP domain Pox_L3_FP4 PF03339.14 PIK38192.1 - 0.056 12.4 0.9 0.083 11.9 0.9 1.2 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein 7tm_1 PF00001.21 PIK38193.1 - 1.5e-41 142.4 19.0 1.9e-41 142.1 19.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK38193.1 - 8.2e-14 51.6 20.8 1.1e-13 51.2 20.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK38193.1 - 0.00042 20.0 22.1 0.001 18.8 21.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK38193.1 - 0.0015 17.9 19.1 0.0022 17.4 19.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF4781 PF16013.5 PIK38193.1 - 0.024 13.4 0.1 0.08 11.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) Methyltransf_23 PF13489.6 PIK38194.1 - 1.3e-08 34.9 0.0 1.6e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK38194.1 - 0.00024 21.7 0.0 0.00041 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK38194.1 - 0.00065 20.4 0.0 0.0011 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK38194.1 - 0.012 16.3 0.0 0.032 15.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK38195.1 - 1.1e-07 31.8 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK38195.1 - 0.0029 18.2 0.0 0.0059 17.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK38195.1 - 0.0053 17.4 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FAM180 PF15173.6 PIK38195.1 - 0.015 15.3 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 FAM180 family Protocadherin PF08374.11 PIK38196.1 - 0.00073 19.6 0.1 0.00081 19.4 0.1 1.1 1 0 0 1 1 1 1 Protocadherin TMEM154 PF15102.6 PIK38196.1 - 0.00099 19.0 0.5 0.0011 18.8 0.5 1.1 1 0 0 1 1 1 1 TMEM154 protein family SUR7 PF06687.12 PIK38196.1 - 0.0036 16.9 0.2 0.0044 16.7 0.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family ECSCR PF15820.5 PIK38196.1 - 0.012 15.4 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4446 PF14584.6 PIK38196.1 - 0.032 14.2 0.2 0.043 13.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) PRIMA1 PF16101.5 PIK38196.1 - 0.032 14.2 0.1 0.046 13.8 0.1 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 PIK38196.1 - 0.045 14.6 0.1 0.063 14.2 0.1 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 PIK38196.1 - 0.83 9.5 5.8 1.2 8.9 5.8 1.2 1 0 0 1 1 1 0 Rifin FeoB_associated PF12669.7 PIK38196.1 - 9.7 6.7 6.1 16 5.9 6.1 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Pkinase_Tyr PF07714.17 PIK38197.1 - 4.8e-18 65.4 0.0 7.7e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 PIK38197.1 - 3.2e-13 49.6 2.1 6.1e-06 26.2 0.2 3.5 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Pkinase PF00069.25 PIK38197.1 - 9.7e-10 38.2 0.0 2.2e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Ig_2 PF13895.6 PIK38197.1 - 2.7e-07 30.8 6.4 0.11 12.8 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.6 PIK38197.1 - 2e-06 28.3 4.3 1.3 9.7 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK38197.1 - 0.0015 18.6 0.9 8.4 6.7 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin domain COP23 PF14218.6 PIK38197.1 - 0.065 13.0 0.3 0.63 9.8 0.1 2.4 2 0 0 2 2 2 0 Circadian oscillating protein COP23 RT_RNaseH_2 PF17919.1 PIK38198.1 - 1.2e-06 28.5 0.1 2.3e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38198.1 - 0.00016 21.3 0.0 0.00035 20.2 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK38199.1 - 9.8e-18 64.6 0.0 4.6e-17 62.4 0.0 2.1 2 0 0 2 2 2 1 NACHT domain Ig_2 PF13895.6 PIK38199.1 - 5.5e-06 26.6 2.5 0.28 11.6 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK38199.1 - 1.8e-05 24.7 4.6 0.0071 16.4 0.2 3.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK38199.1 - 0.00088 19.8 3.8 1.4 9.6 0.0 4.6 3 1 1 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK38199.1 - 0.006 16.8 0.4 0.055 13.7 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK38199.1 - 0.0068 16.3 0.8 0.0068 16.3 0.8 1.9 2 0 0 2 2 2 1 TMEM154 protein family I-set PF07679.16 PIK38199.1 - 0.0074 16.3 0.9 2.3 8.3 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain AAA_25 PF13481.6 PIK38199.1 - 0.016 14.8 0.0 0.043 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK38199.1 - 0.021 15.1 0.0 0.054 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain C1-set PF07654.15 PIK38199.1 - 0.025 15.0 4.2 0.8 10.1 0.8 2.8 2 0 0 2 2 2 0 Immunoglobulin C1-set domain ig PF00047.25 PIK38199.1 - 0.052 13.7 0.7 3.2 8.0 0.0 3.0 2 0 0 2 2 2 0 Immunoglobulin domain Marek_A PF02124.15 PIK38199.1 - 0.067 13.0 1.9 0.17 11.7 1.9 1.7 1 0 0 1 1 1 0 Marek's disease glycoprotein A GPI2 PF06432.11 PIK38199.1 - 0.079 12.4 3.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase DAG1 PF05454.11 PIK38199.1 - 0.19 11.1 0.7 0.33 10.3 0.7 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) 7tm_2 PF00002.24 PIK38200.1 - 2.7e-31 108.7 20.5 4e-31 108.2 20.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK38200.1 - 6e-15 55.5 2.5 1.1e-14 54.6 2.5 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif UPF0139 PF03669.13 PIK38200.1 - 0.03 14.2 2.5 0.05 13.5 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) DUF2956 PF11169.8 PIK38200.1 - 0.27 11.4 0.1 0.27 11.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) LRAT PF04970.13 PIK38203.1 - 0.0013 19.0 0.2 0.009 16.3 0.0 2.1 2 0 0 2 2 2 1 Lecithin retinol acyltransferase LRR_4 PF12799.7 PIK38204.1 - 2.4e-25 88.2 36.3 2e-07 31.2 4.3 6.7 4 1 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK38204.1 - 1.6e-18 66.2 38.5 1.1e-06 28.3 4.9 6.3 6 2 0 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 PIK38204.1 - 5e-15 55.4 14.1 2.4e-07 30.4 5.5 3.7 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 PIK38204.1 - 5.7e-06 26.0 25.5 0.32 11.2 0.2 8.8 9 0 0 9 9 9 4 Leucine Rich repeat CSRNP_N PF16019.5 PIK38204.1 - 0.079 12.9 8.8 0.038 13.9 2.8 2.2 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus LRR_2 PF07723.13 PIK38204.1 - 0.16 12.7 3.8 5.7 7.8 0.1 4.2 3 0 0 3 3 3 0 Leucine Rich Repeat TRPM_tetra PF16519.5 PIK38204.1 - 1.3 9.2 6.3 1.6 8.9 0.3 3.9 4 0 0 4 4 4 0 Tetramerisation domain of TRPM TMEM220 PF15071.6 PIK38205.1 - 6e-09 36.6 0.8 8.8e-09 36.1 0.3 1.5 2 0 0 2 2 2 1 Transmembrane family 220, helix MARVEL PF01284.23 PIK38205.1 - 0.8 9.7 7.2 0.26 11.3 0.6 2.1 2 0 0 2 2 2 0 Membrane-associating domain CARD PF00619.21 PIK38206.1 - 1.3e-11 44.4 0.1 6.2e-11 42.2 0.0 2.3 2 0 0 2 2 2 1 Caspase recruitment domain Pkinase_Tyr PF07714.17 PIK38207.1 - 2.4e-26 92.6 0.0 2.6e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK38207.1 - 3.2e-15 56.2 0.0 3.5e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38208.1 - 5.7e-20 71.7 0.2 6.4e-20 71.5 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK38208.1 - 0.0026 17.2 0.0 0.003 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TOM6p PF15184.6 PIK38208.1 - 0.17 11.7 0.1 0.28 11.0 0.1 1.4 1 1 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog PHD_4 PF16866.5 PIK38209.1 - 0.12 12.5 2.5 0.45 10.6 0.6 2.7 3 0 0 3 3 3 0 PHD-finger EF1G PF00647.19 PIK38210.1 - 0.037 14.1 0.2 0.089 12.8 0.2 1.6 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain Alpha_L_fucos PF01120.17 PIK38211.1 - 7.7e-66 222.9 10.6 9.9e-66 222.6 10.6 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 PIK38211.1 - 0.14 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Alpha_L_fucos PF01120.17 PIK38212.1 - 2.8e-52 178.3 0.3 4.3e-52 177.7 0.3 1.3 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 PIK38212.1 - 1.3e-26 93.0 0.9 2e-26 92.4 0.9 1.3 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Aminotran_3 PF00202.21 PIK38213.1 - 7.1e-107 357.5 0.0 8.8e-107 357.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III PWWP PF00855.17 PIK38214.1 - 1.2e-10 41.7 0.7 1.2e-10 41.7 0.7 2.2 2 0 0 2 2 2 1 PWWP domain ADD_DNMT3 PF17980.1 PIK38215.1 - 2.7e-16 59.3 0.6 2.7e-16 59.3 0.6 2.5 2 0 0 2 2 2 1 Cysteine rich ADD domain in DNMT3 DNA_methylase PF00145.17 PIK38215.1 - 3.7e-16 59.4 0.0 2.5e-11 43.5 0.0 2.1 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase zf-4CXXC_R1 PF10497.9 PIK38215.1 - 2.8 8.2 10.8 0.75 10.1 6.8 2.1 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DSPn PF14671.6 PIK38216.1 - 2e-47 161.2 0.3 2.7e-46 157.5 0.3 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 PIK38216.1 - 1.5e-14 54.0 0.0 4.1e-14 52.5 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK38216.1 - 0.00031 20.4 0.0 0.0005 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK38216.1 - 0.0088 16.2 0.0 0.017 15.3 0.0 1.5 1 1 0 1 1 1 1 Inositol hexakisphosphate Peptidase_M1 PF01433.20 PIK38217.1 - 5.1e-20 72.0 0.0 1.1e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 PIK38217.1 - 1.2e-13 51.1 0.0 2.7e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 PIK38217.1 - 1.1e-07 32.2 0.3 4.2e-05 23.8 0.0 2.8 3 0 0 3 3 3 2 Peptidase M1 N-terminal domain Thioredoxin PF00085.20 PIK38218.1 - 1.5e-30 105.2 0.1 1.8e-30 105.0 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 PIK38218.1 - 1.3e-07 31.5 0.1 2.6e-07 30.6 0.1 1.6 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 PIK38218.1 - 3.7e-07 30.4 0.0 4.6e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK38218.1 - 7.7e-06 26.3 0.1 2e-05 25.0 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 PIK38218.1 - 1.9e-05 24.4 0.0 2e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 PIK38218.1 - 2.5e-05 24.4 0.1 5.5e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 PIK38218.1 - 4.4e-05 23.2 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin TraF PF13728.6 PIK38218.1 - 0.00014 21.8 0.0 0.00015 21.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 PIK38218.1 - 0.00054 19.4 0.0 0.00064 19.2 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family gpW PF02831.15 PIK38218.1 - 0.0022 17.8 0.0 0.005 16.7 0.0 1.6 1 0 0 1 1 1 1 gpW DIM1 PF02966.16 PIK38218.1 - 0.016 15.0 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 Phosducin PF02114.16 PIK38218.1 - 0.027 13.4 0.0 0.03 13.3 0.0 1.0 1 0 0 1 1 1 0 Phosducin p450 PF00067.22 PIK38219.1 - 8.3e-109 364.4 0.0 4.1e-90 302.7 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 UDPG_MGDP_dh PF00984.19 PIK38219.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain adh_short PF00106.25 PIK38220.1 - 3.2e-35 121.4 0.0 5.3e-35 120.7 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38220.1 - 1.7e-26 93.2 0.0 2.2e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38220.1 - 0.00062 19.7 0.0 0.00093 19.1 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 PIK38220.1 - 0.16 11.3 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) TPT PF03151.16 PIK38221.1 - 1.3e-14 54.3 16.4 1.6e-14 53.9 16.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family RP853 PF17542.2 PIK38221.1 - 0.084 12.0 0.2 0.15 11.1 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized RP853 Sulfotransfer_1 PF00685.27 PIK38222.1 - 3.2e-41 141.6 0.0 3.6e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK38222.1 - 1.7e-05 25.3 0.0 3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family SIKE PF05769.11 PIK38223.1 - 1.6e-58 197.6 21.2 2.6e-58 196.9 21.2 1.3 1 0 0 1 1 1 1 SIKE family BING4CT PF08149.11 PIK38223.1 - 0.063 13.1 0.0 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 BING4CT (NUC141) domain RecG_N PF17190.4 PIK38223.1 - 0.15 12.8 0.1 0.15 12.8 0.1 3.0 2 1 0 3 3 3 0 RecG N-terminal helical domain Fib_alpha PF08702.10 PIK38223.1 - 1 9.5 14.0 0.35 11.0 1.8 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family NEMO PF11577.8 PIK38223.1 - 1.9 8.5 16.1 4.1 7.5 5.4 3.6 3 1 0 3 3 3 0 NF-kappa-B essential modulator NEMO NYD-SP28_assoc PF14775.6 PIK38223.1 - 2.6 8.2 8.9 11 6.3 1.2 3.5 3 0 0 3 3 3 0 Sperm tail C-terminal domain ING PF12998.7 PIK38223.1 - 3.3 8.4 12.4 1.6 9.4 2.6 3.4 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding ATG16 PF08614.11 PIK38223.1 - 6.9 6.8 24.2 1 9.5 19.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Ion_trans PF00520.31 PIK38224.1 - 9.5e-41 139.6 5.5 1.1e-40 139.4 5.5 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK38224.1 - 3.1e-11 43.1 2.3 3.1e-11 43.1 2.3 2.1 2 0 0 2 2 2 1 Ion channel DUF3185 PF11381.8 PIK38224.1 - 0.0066 16.4 2.9 0.0066 16.4 2.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3185) TraG_N PF07916.11 PIK38224.1 - 0.34 9.7 3.8 0.12 11.2 0.2 1.9 2 1 0 2 2 2 0 TraG-like protein, N-terminal region PGPGW PF09656.10 PIK38224.1 - 4.1 7.0 9.2 14 5.3 4.5 2.4 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) Peptidase_M16_C PF05193.21 PIK38225.1 - 1.2e-12 48.2 0.0 2.3e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 PIK38225.1 - 6.9e-08 32.6 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Herpes_pp85 PF04637.12 PIK38227.1 - 0.056 11.9 0.1 0.069 11.6 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) FAM176 PF14851.6 PIK38227.1 - 0.062 13.0 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 PIK38227.1 - 0.064 12.1 4.0 0.082 11.8 4.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 EGF_CA PF07645.15 PIK38227.1 - 1.1 9.6 11.0 1.8 8.9 11.0 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain cEGF PF12662.7 PIK38228.1 - 0.0021 17.9 0.7 0.0059 16.5 0.7 1.8 1 0 0 1 1 1 1 Complement Clr-like EGF-like TIL PF01826.17 PIK38228.1 - 0.075 13.3 5.5 0.15 12.3 5.5 1.5 1 1 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.7 PIK38228.1 - 0.45 11.2 10.7 3.3 8.5 8.2 3.1 2 1 0 2 2 2 0 Human growth factor-like EGF EB PF01683.18 PIK38228.1 - 0.52 10.6 6.7 1.1 9.6 6.7 1.6 1 1 0 1 1 1 0 EB module EGF_2 PF07974.13 PIK38228.1 - 1.4 9.3 11.6 4.8 7.6 9.3 2.7 2 1 0 2 2 2 0 EGF-like domain Sushi PF00084.20 PIK38229.1 - 6.9e-23 81.0 31.6 2.9e-08 34.2 2.4 5.8 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) SEA PF01390.20 PIK38229.1 - 1.6e-06 28.1 1.6 1.6e-06 28.1 1.6 3.4 4 0 0 4 4 4 1 SEA domain Abhydrolase_1 PF00561.20 PIK38230.1 - 5.2e-31 108.2 0.1 2.2e-30 106.2 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK38230.1 - 4.5e-13 50.3 0.4 6e-13 49.9 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family HAD_2 PF13419.6 PIK38230.1 - 5e-12 46.2 0.0 1.8e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_4 PF12146.8 PIK38230.1 - 1.5e-09 37.5 0.0 2.6e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase PF00702.26 PIK38230.1 - 1.7e-07 31.7 0.0 1.8e-06 28.4 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK38230.1 - 0.00049 20.1 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 PIK38230.1 - 0.053 13.6 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Glyoxalase_4 PF13669.6 PIK38230.1 - 0.079 13.2 0.0 1.2 9.5 0.0 2.6 3 1 0 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fibrinogen_C PF00147.18 PIK38231.1 - 5.8e-25 88.4 5.7 1.2e-23 84.1 5.7 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38231.1 - 8.5e-05 22.7 6.9 8.5e-05 22.7 6.9 3.3 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38231.1 - 0.00013 22.1 7.3 0.00013 22.1 7.3 3.2 3 1 0 3 3 3 1 EGF domain TILa PF12714.7 PIK38231.1 - 0.0015 18.4 1.2 0.0015 18.4 1.2 2.5 2 0 0 2 2 2 1 TILa domain cEGF PF12662.7 PIK38231.1 - 0.0015 18.4 7.2 0.44 10.5 4.0 3.7 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK38231.1 - 1.1 9.7 23.3 0.092 13.1 3.3 3.4 2 2 0 2 2 2 0 EGF-like domain Fibrinogen_C PF00147.18 PIK38232.1 - 8.8e-72 241.5 5.5 4.5e-37 128.0 3.0 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK38232.1 - 0.0002 21.5 9.9 0.0002 21.5 9.9 3.2 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK38232.1 - 0.0017 18.3 5.0 0.0017 18.3 5.0 2.0 1 1 1 2 2 2 1 TILa domain COLFI PF01410.18 PIK38232.1 - 0.0032 16.8 1.3 0.008 15.5 0.3 2.0 2 1 0 2 2 2 1 Fibrillar collagen C-terminal domain EGF_Tenascin PF18720.1 PIK38232.1 - 0.012 15.6 0.2 0.012 15.6 0.2 3.4 3 0 0 3 3 3 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK38233.1 - 1.1e-15 58.0 4.8 1.2e-15 57.9 4.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38234.1 - 1.6e-15 57.5 3.2 1.8e-15 57.3 3.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF2498 PF10692.9 PIK38235.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) LAMTOR PF15454.6 PIK38236.1 - 2.2e-15 57.0 0.0 3.7e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Solute_trans_a PF03619.16 PIK38237.1 - 1.7e-16 60.6 1.3 2.6e-06 27.2 0.0 3.1 2 1 1 3 3 3 3 Organic solute transporter Ostalpha DUF2048 PF09752.9 PIK38238.1 - 2.9e-24 85.9 0.0 3.2e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 Abhydrolase domain containing 18 DUF3613 PF12266.8 PIK38238.1 - 0.069 12.9 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) DUF2048 PF09752.9 PIK38239.1 - 3.3e-43 148.1 0.0 5e-37 127.8 0.0 2.1 2 0 0 2 2 2 2 Abhydrolase domain containing 18 RVT_1 PF00078.27 PIK38239.1 - 0.00036 20.1 0.0 0.00058 19.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lebercilin PF15619.6 PIK38239.1 - 0.046 13.4 0.1 0.068 12.8 0.1 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Maf PF02545.14 PIK38240.1 - 5.8e-48 162.9 0.0 6.9e-48 162.6 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein zf-SAP30 PF13866.6 PIK38241.1 - 2.6e-35 120.4 9.0 6.3e-35 119.1 9.0 1.7 1 0 0 1 1 1 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.6 PIK38241.1 - 1.1e-23 83.3 1.1 2.9e-23 82.0 1.1 1.8 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 THAP PF05485.12 PIK38241.1 - 7.1e-15 55.7 0.6 7.1e-15 55.7 0.6 3.0 2 1 1 3 3 3 1 THAP domain SUZ PF12752.7 PIK38241.1 - 0.04 14.7 0.1 0.6 10.9 0.0 2.7 2 0 0 2 2 2 0 SUZ domain HMG_box PF00505.19 PIK38242.1 - 5.3e-32 110.0 11.9 1.1e-20 73.8 2.8 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK38242.1 - 6.4e-29 100.4 13.8 5.7e-16 58.9 2.6 2.4 2 0 0 2 2 2 2 HMG-box domain IMUP PF15761.5 PIK38242.1 - 0.0058 17.3 12.7 0.0058 17.3 12.7 2.6 3 0 0 3 3 3 1 Immortalisation up-regulated protein DUF755 PF05501.11 PIK38242.1 - 0.0071 16.6 18.3 0.0071 16.6 18.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF755) FTCD_C PF04961.12 PIK38242.1 - 0.065 13.0 4.7 0.43 10.3 0.7 2.1 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase GREB1 PF15782.5 PIK38242.1 - 3.3 4.7 8.9 3.5 4.6 8.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RNase_PH PF01138.21 PIK38244.1 - 5.6e-19 69.0 0.1 1.4e-18 67.6 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK38244.1 - 5.1e-11 42.4 0.1 1.1e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 7tm_1 PF00001.21 PIK38245.1 - 2.3e-17 63.2 5.4 3e-17 62.8 5.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK38245.1 - 3e-05 23.8 10.9 4e-05 23.4 10.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK38245.1 - 0.016 14.6 8.6 0.029 13.8 8.6 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx SSF PF00474.17 PIK38246.1 - 4.5e-122 407.8 28.0 6.1e-122 407.4 28.0 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Astro_capsid_p PF12226.8 PIK38246.1 - 0.058 12.5 7.3 0.094 11.9 7.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sec62 PF03839.16 PIK38246.1 - 0.11 11.9 0.2 0.29 10.6 0.2 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 Rav1p_C PF12234.8 PIK38246.1 - 0.49 8.7 1.1 0.68 8.3 1.1 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal TRAP_alpha PF03896.16 PIK38246.1 - 0.79 8.9 3.6 1.3 8.1 3.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RR_TM4-6 PF06459.12 PIK38246.1 - 0.83 9.4 5.8 1.3 8.8 5.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4834 PF16118.5 PIK38246.1 - 1.5 9.9 0.0 1.5 9.9 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Sporozoite_P67 PF05642.11 PIK38246.1 - 1.6 6.8 3.1 2.3 6.2 3.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 PIK38246.1 - 4.1 5.5 13.7 5.5 5.1 13.7 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 PIK38246.1 - 5.9 6.2 12.7 8.3 5.7 12.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RVT_1 PF00078.27 PIK38247.1 - 0.00013 21.6 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK38248.1 - 6e-09 35.7 0.1 7.4e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CotJB PF12652.7 PIK38248.1 - 0.044 14.0 0.1 0.076 13.2 0.1 1.4 1 0 0 1 1 1 0 CotJB protein CK_II_beta PF01214.18 PIK38248.1 - 0.096 12.5 1.7 0.19 11.5 0.3 1.8 1 1 0 2 2 2 0 Casein kinase II regulatory subunit 7tm_1 PF00001.21 PIK38249.1 - 2.1e-31 109.2 12.8 2.1e-31 109.2 12.8 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK38249.1 - 1.8e-08 34.1 18.0 1.3e-06 28.0 13.2 2.4 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Pho88 PF10032.9 PIK38249.1 - 0.094 12.0 0.7 0.32 10.2 0.2 2.2 2 0 0 2 2 2 0 Phosphate transport (Pho88) Erg28 PF03694.13 PIK38249.1 - 6.1 7.3 14.9 0.21 12.0 7.9 2.3 3 0 0 3 3 3 0 Erg28 like protein CD225 PF04505.12 PIK38250.1 - 0.014 15.5 0.7 0.02 15.0 0.7 1.2 1 0 0 1 1 1 0 Interferon-induced transmembrane protein DUF3071 PF11268.8 PIK38250.1 - 0.06 13.4 1.3 8.7 6.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3071) MAGI_u1 PF16663.5 PIK38250.1 - 0.13 12.4 0.4 25 5.0 0.1 2.4 2 0 0 2 2 2 0 Unstructured region on MAGI DUF2092 PF09865.9 PIK38250.1 - 0.33 10.3 1.0 9.9 5.4 0.1 2.1 2 0 0 2 2 2 0 Predicted periplasmic protein (DUF2092) Cylicin_N PF15241.6 PIK38250.1 - 0.48 10.6 2.7 15 5.7 0.4 2.2 2 0 0 2 2 2 0 Cylicin N-terminus Bim_N PF06773.11 PIK38250.1 - 7 6.4 15.5 1.6 8.5 0.8 3.0 4 0 0 4 4 4 0 Bim protein N-terminus Lectin_C PF00059.21 PIK38251.1 - 5e-14 52.9 1.2 5e-14 52.9 1.2 2.0 2 1 1 3 3 3 1 Lectin C-type domain EGF_CA PF07645.15 PIK38251.1 - 0.00086 19.5 11.9 0.0023 18.1 11.9 1.7 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF PF00008.27 PIK38251.1 - 0.012 15.9 4.8 0.017 15.4 3.4 2.1 1 1 0 1 1 1 0 EGF-like domain EGF_3 PF12947.7 PIK38251.1 - 0.019 15.1 10.0 0.05 13.8 10.0 1.8 1 0 0 1 1 1 0 EGF domain Plasmod_Pvs28 PF06247.11 PIK38251.1 - 0.034 14.4 4.3 0.081 13.2 4.3 1.6 1 0 0 1 1 1 0 Pvs28 EGF domain hEGF PF12661.7 PIK38251.1 - 5.1 7.9 8.7 4.9 7.9 2.3 3.3 3 1 0 3 3 3 0 Human growth factor-like EGF RVT_1 PF00078.27 PIK38252.1 - 4.5e-16 59.0 0.0 5.5e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Neisseria_TspB PF05616.13 PIK38252.1 - 0.7 8.3 4.1 1.1 7.7 4.1 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein ABC2_membrane PF01061.24 PIK38253.1 - 6.9e-24 84.4 16.9 6.9e-24 84.4 16.9 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 PIK38253.1 - 8.7e-20 71.6 0.1 1.4e-19 70.9 0.1 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 PIK38253.1 - 0.019 14.8 0.0 0.069 13.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK38253.1 - 0.029 13.8 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_9 PF12781.7 PIK38254.1 - 3e-48 163.8 2.2 6.8e-48 162.7 2.2 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK38254.1 - 1.6e-43 148.4 0.0 3.2e-43 147.4 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 PIK38254.1 - 2.5e-33 115.6 0.1 2.5e-33 115.6 0.1 2.0 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 PIK38254.1 - 2.1e-21 76.2 0.1 1e-20 74.0 0.0 2.1 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK38255.1 - 1.5e-160 533.9 5.2 1.8e-160 533.6 5.2 1.0 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Spc7 PF08317.11 PIK38255.1 - 0.0047 15.9 2.9 0.0047 15.9 2.9 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein APG6_N PF17675.1 PIK38255.1 - 0.053 14.1 0.5 0.053 14.1 0.5 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 PIK38255.1 - 0.066 13.2 2.9 0.14 12.2 2.9 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vps5 PF09325.10 PIK38255.1 - 0.088 12.3 7.0 0.15 11.6 0.4 2.3 2 0 0 2 2 2 0 Vps5 C terminal like DUF3584 PF12128.8 PIK38255.1 - 0.57 7.6 3.9 0.54 7.7 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Exonuc_VII_S PF02609.16 PIK38255.1 - 0.7 10.0 5.9 8 6.6 0.0 3.0 2 1 1 3 3 3 0 Exonuclease VII small subunit Sfi1_C PF10638.9 PIK38255.1 - 0.81 10.5 5.1 0.36 11.6 1.3 2.2 2 1 1 3 3 3 0 Spindle body associated protein C-terminus GrpE PF01025.19 PIK38255.1 - 6.5 6.4 7.0 2.6 7.7 3.7 1.9 2 0 0 2 2 2 0 GrpE DUF4140 PF13600.6 PIK38255.1 - 7.2 7.1 7.7 2.1 8.8 1.4 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) AAA_6 PF12774.7 PIK38256.1 - 5.1e-155 515.4 0.0 1.7e-154 513.7 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK38256.1 - 2.5e-104 349.6 8.7 2.5e-104 349.6 8.7 1.8 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 PIK38256.1 - 3.7e-74 248.2 0.4 1.7e-66 223.2 0.1 4.0 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA_8 PF12780.7 PIK38256.1 - 3.5e-52 177.3 3.6 1.1e-40 139.6 0.0 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region D4 AAA_lid_1 PF17857.1 PIK38256.1 - 8.5e-47 157.5 2.9 9.8e-47 157.3 0.5 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 PIK38256.1 - 4e-26 91.7 0.0 1.1e-11 44.8 0.0 5.7 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 PIK38256.1 - 3.1e-16 59.7 0.1 1.3e-15 57.6 0.1 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 PIK38256.1 - 3.5e-08 34.0 0.2 0.19 12.1 0.0 4.7 4 0 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 PIK38256.1 - 2.6e-05 24.5 1.1 2.2 8.6 0.0 4.5 4 0 0 4 4 3 2 AAA domain AAA_30 PF13604.6 PIK38256.1 - 4.9e-05 23.1 0.2 0.079 12.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 PIK38256.1 - 8.9e-05 22.9 0.3 0.23 11.9 0.0 4.6 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK38256.1 - 0.00014 22.5 3.4 1.2 9.7 0.0 4.9 5 0 0 5 5 4 2 AAA domain ABC_tran PF00005.27 PIK38256.1 - 0.00019 21.9 0.2 3.9 8.0 0.0 4.5 4 0 0 4 4 4 1 ABC transporter Sigma54_activat PF00158.26 PIK38256.1 - 0.0022 17.7 0.1 0.21 11.3 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain DUF815 PF05673.13 PIK38256.1 - 0.0057 15.9 1.0 4.9 6.2 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 PIK38256.1 - 0.0092 16.4 0.1 22 5.5 0.0 3.6 3 0 0 3 3 3 0 RNA helicase Rad17 PF03215.15 PIK38256.1 - 0.023 14.6 0.3 25 4.7 0.0 3.9 4 0 0 4 4 4 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 PIK38256.1 - 0.034 14.1 1.2 4 7.3 0.0 2.9 3 0 0 3 3 2 0 RsgA GTPase PhoH PF02562.16 PIK38256.1 - 0.038 13.5 0.2 13 5.1 0.0 3.8 4 0 0 4 4 3 0 PhoH-like protein AAA_29 PF13555.6 PIK38256.1 - 0.046 13.5 1.3 61 3.5 0.0 3.8 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_19 PF13245.6 PIK38256.1 - 0.048 14.0 5.2 0.46 10.8 0.0 3.7 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 PIK38256.1 - 0.067 12.6 4.1 0.9 8.9 0.0 3.6 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 PIK38256.1 - 0.14 12.3 0.5 4.3 7.4 0.0 3.2 4 0 0 4 4 2 0 Sigma-54 interaction domain TsaE PF02367.17 PIK38256.1 - 0.16 12.0 0.4 20 5.2 0.1 3.3 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ploopntkinase3 PF18751.1 PIK38256.1 - 0.18 11.7 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_33 PF13671.6 PIK38256.1 - 0.31 11.2 1.6 69 3.6 0.0 4.1 4 0 0 4 4 4 0 AAA domain ABC_tran_CTD PF16326.5 PIK38256.1 - 0.35 11.1 7.2 0.32 11.3 0.2 3.6 3 0 0 3 3 3 0 ABC transporter C-terminal domain AAA_25 PF13481.6 PIK38256.1 - 0.48 10.0 2.6 1.4 8.4 0.0 3.0 4 0 0 4 4 3 0 AAA domain NACHT PF05729.12 PIK38256.1 - 2.6 7.9 6.9 9 6.2 0.0 3.7 5 0 0 5 5 3 0 NACHT domain DUF87 PF01935.17 PIK38256.1 - 4.5 7.3 6.2 8.5 6.4 0.0 3.7 3 0 0 3 3 3 0 Helicase HerA, central domain DHC_N1 PF08385.12 PIK38257.1 - 2.5e-180 600.9 24.2 6.8e-180 599.4 6.5 3.4 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 PIK38257.1 - 5.4e-15 55.4 1.4 5.4e-15 55.4 1.4 6.5 6 2 0 6 6 6 1 Dynein heavy chain, N-terminal region 2 DUF1664 PF07889.12 PIK38257.1 - 0.057 13.4 14.1 0.17 12.0 0.1 6.1 6 0 0 6 6 6 0 Protein of unknown function (DUF1664) DUF1563 PF07599.11 PIK38257.1 - 0.11 12.6 1.5 0.36 11.0 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) RUN PF02759.19 PIK38257.1 - 0.11 12.4 0.0 3.9 7.4 0.0 3.2 3 0 0 3 3 3 0 RUN domain Spore_YhcN_YlaJ PF09580.10 PIK38257.1 - 0.16 12.0 0.2 0.91 9.6 0.0 2.5 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Med9 PF07544.13 PIK38257.1 - 0.85 9.7 7.7 12 6.0 0.1 4.5 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Plk4_PB2 PF18409.1 PIK38257.1 - 1 10.1 6.4 2.7 8.7 0.1 4.5 4 0 0 4 4 4 0 Polo-like Kinase 4 Polo Box 2 AKNA PF12443.8 PIK38257.1 - 2.4 8.9 9.5 3.8 8.2 0.3 3.7 3 0 0 3 3 3 0 AT-hook-containing transcription factor DASH_Dad2 PF08654.10 PIK38257.1 - 9.1 6.8 11.3 17 5.9 0.0 4.5 4 0 0 4 4 4 0 DASH complex subunit Dad2 YtxH PF12732.7 PIK38257.1 - 9.3 6.9 8.9 20 5.8 0.1 4.5 4 1 0 4 4 3 0 YtxH-like protein Alpha_L_fucos PF01120.17 PIK38258.1 - 1.8e-118 396.0 12.5 2.3e-118 395.7 12.5 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 PIK38258.1 - 3.4e-26 91.6 0.5 3.4e-26 91.6 0.5 1.7 2 0 0 2 2 2 1 Alpha-L-fucosidase C-terminal domain GHL6 PF14871.6 PIK38258.1 - 0.011 15.8 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 VERL PF11386.8 PIK38258.1 - 0.13 12.5 0.2 2 8.6 0.1 2.5 2 0 0 2 2 2 0 Vitelline envelope receptor for lysin Ank_4 PF13637.6 PIK38259.1 - 4.4e-15 55.8 0.0 9.1e-11 42.1 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK38259.1 - 5.4e-13 49.3 0.0 2.3e-12 47.3 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK38259.1 - 2e-08 33.8 0.0 0.00017 21.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK38259.1 - 6.5e-08 32.7 0.3 0.00075 19.7 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK38259.1 - 1.6e-07 31.4 0.1 0.00011 22.4 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat SAM_1 PF00536.30 PIK38259.1 - 0.00052 20.4 0.1 0.0017 18.8 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) BCAS2 PF05700.11 PIK38259.1 - 0.014 15.1 5.4 0.083 12.6 5.4 2.0 1 1 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Ras PF00071.22 PIK38260.1 - 3.7e-17 62.4 0.3 4.9e-17 62.0 0.3 1.1 1 0 0 1 1 1 1 Ras family Pinin_SDK_N PF04697.13 PIK38260.1 - 0.0017 19.0 0.1 0.003 18.2 0.1 1.4 1 0 0 1 1 1 1 pinin/SDK conserved region GTP_EFTU PF00009.27 PIK38260.1 - 0.006 16.1 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 PIK38260.1 - 0.022 14.7 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RVT_1 PF00078.27 PIK38261.1 - 2.4e-19 69.7 0.3 4.8e-19 68.8 0.1 1.5 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF469 PF04320.14 PIK38261.1 - 0.024 15.5 0.0 0.031 15.1 0.0 1.1 1 0 0 1 1 1 0 Protein with unknown function (DUF469) rve PF00665.26 PIK38263.1 - 2.4e-08 34.2 0.0 4.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK38264.1 - 6.6e-25 87.1 0.0 1.1e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38264.1 - 2.7e-14 53.2 0.0 5.1e-14 52.3 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK38264.1 - 7.6e-14 51.9 0.0 1.4e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Baculo_DNA_bind PF04786.12 PIK38265.1 - 0.2 11.0 0.0 0.37 10.1 0.0 1.3 1 0 0 1 1 1 0 ssDNA binding protein Peptidase_A17 PF05380.13 PIK38267.1 - 2.6e-49 167.3 0.0 4.1e-49 166.7 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK38267.1 - 1.4e-08 34.9 0.0 3.3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38267.1 - 6e-05 23.1 0.6 0.00012 22.1 0.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK38267.1 - 0.03 14.3 0.0 0.086 12.9 0.0 1.7 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38267.1 - 0.036 14.4 0.0 0.09 13.1 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase MULE PF10551.9 PIK38270.1 - 2.3e-13 50.4 0.0 4.3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain RT_RNaseH PF17917.1 PIK38271.1 - 1.2e-27 96.2 0.0 2.9e-27 95.0 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK38271.1 - 1.1e-25 89.5 0.0 2.9e-25 88.2 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK38271.1 - 2e-15 57.0 0.0 4e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38271.1 - 6.3e-05 23.0 0.1 0.00015 21.8 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK38271.1 - 0.00013 21.5 0.0 0.00027 20.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 PIK38271.1 - 0.0081 16.0 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 PIK38271.1 - 1.2 9.3 14.2 0.082 13.0 3.4 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38271.1 - 6.8 6.6 10.9 0.18 11.6 3.7 2.2 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK38272.1 - 3.2e-27 94.5 0.0 8.4e-27 93.1 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38272.1 - 7.4e-17 61.6 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK38272.1 - 1.7e-14 53.9 0.0 3.7e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Retrotrans_gag PF03732.17 PIK38272.1 - 0.05 13.9 0.0 0.72 10.2 0.0 2.7 2 0 0 2 2 2 0 Retrotransposon gag protein Baculo_DNA_bind PF04786.12 PIK38273.1 - 0.17 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 ssDNA binding protein Exo_endo_phos PF03372.23 PIK38274.1 - 2.5e-05 23.9 0.4 3.8e-05 23.3 0.4 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38274.1 - 0.086 12.7 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DNA_ligase_ZBD PF03119.16 PIK38275.1 - 0.0099 15.9 0.1 0.022 14.8 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain Myb_DNA-bind_4 PF13837.6 PIK38276.1 - 0.00033 21.0 0.9 0.00033 21.0 0.9 2.7 2 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain DUF3372 PF11852.8 PIK38277.1 - 0.17 11.3 0.0 0.53 9.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3372) LRR_8 PF13855.6 PIK38278.1 - 2.3e-21 75.3 12.6 1.9e-10 40.4 2.0 3.8 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK38278.1 - 2e-12 47.1 14.0 0.0058 17.0 0.1 4.8 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK38278.1 - 1.9e-06 27.9 1.9 0.0039 17.1 1.6 2.5 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Ephrin_rec_like PF07699.13 PIK38278.1 - 8.2e-05 22.3 19.0 0.0015 18.3 1.6 3.2 2 1 1 3 3 3 2 Putative ephrin-receptor like LRR_9 PF14580.6 PIK38278.1 - 0.0008 18.9 1.4 0.017 14.6 0.4 2.5 1 1 1 2 2 2 1 Leucine-rich repeat NCD3G PF07562.14 PIK38278.1 - 0.072 13.1 15.3 0.39 10.7 1.0 3.4 1 1 3 4 4 4 0 Nine Cysteines Domain of family 3 GPCR LRR_1 PF00560.33 PIK38278.1 - 0.18 12.5 16.2 35 5.5 0.1 7.3 7 1 0 7 7 7 0 Leucine Rich Repeat Pept_S41_N PF18294.1 PIK38278.1 - 0.2 11.7 3.6 1.9 8.6 0.6 3.3 3 1 0 3 3 3 0 Peptidase S41 N-terminal domain DUF4231 PF14015.6 PIK38279.1 - 0.024 15.1 3.4 1.8 9.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) TRP PF06011.12 PIK38279.1 - 1.4 7.6 10.3 0.14 10.8 1.3 2.0 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Exo_endo_phos PF03372.23 PIK38280.1 - 2.7e-11 43.5 0.0 5.6e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38280.1 - 0.038 13.8 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Metallophos PF00149.28 PIK38282.1 - 7.5e-20 72.3 0.4 9.7e-20 71.9 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Lipase_GDSL PF00657.22 PIK38283.1 - 4.5e-12 46.4 0.0 7.6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 PIK38283.1 - 0.00019 21.5 0.3 0.00049 20.1 0.3 1.8 1 0 0 1 1 1 1 Saposin-like type B, region 2 Cu-binding_MopE PF11617.8 PIK38283.1 - 0.74 10.0 12.0 0.054 13.7 4.8 3.0 4 1 0 4 4 4 0 Putative metal-binding motif Lipase_GDSL PF00657.22 PIK38284.1 - 3.5e-13 50.0 0.0 5.1e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3668 PF12416.8 PIK38284.1 - 0.0063 16.3 0.1 0.019 14.8 0.0 1.8 3 0 0 3 3 3 1 Cep120 protein SapB_1 PF05184.15 PIK38284.1 - 0.021 14.9 0.2 0.084 12.9 0.2 2.2 1 1 0 1 1 1 0 Saposin-like type B, region 1 DUF4035 PF13227.6 PIK38284.1 - 0.059 13.1 0.0 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4035) SapB_2 PF03489.17 PIK38284.1 - 0.11 12.7 2.3 0.3 11.2 2.3 1.9 1 0 0 1 1 1 0 Saposin-like type B, region 2 Cu-binding_MopE PF11617.8 PIK38284.1 - 0.36 11.0 6.9 0.056 13.6 1.6 2.5 2 1 0 2 2 2 0 Putative metal-binding motif HEAT PF02985.22 PIK38285.1 - 7.6e-11 41.3 0.1 0.00027 20.9 0.0 4.1 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 PIK38285.1 - 9.4e-08 32.4 0.0 0.042 14.4 0.0 4.7 3 3 2 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 PIK38285.1 - 3.4e-05 24.1 0.0 0.017 15.5 0.0 3.4 2 1 1 3 3 3 1 HEAT repeats IFRD PF05004.13 PIK38285.1 - 0.00016 20.9 0.0 0.001 18.3 0.0 2.2 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 PIK38285.1 - 0.00016 21.8 0.0 1.6 8.8 0.0 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 PIK38285.1 - 0.0072 16.3 1.0 0.052 13.6 0.1 2.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 PIK38285.1 - 0.031 14.9 0.1 33 5.1 0.0 3.6 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region ROK PF00480.20 PIK38285.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 ROK family Speriolin_C PF15059.6 PIK38286.1 - 0.051 13.7 0.7 0.48 10.5 0.0 2.9 3 0 0 3 3 3 0 Speriolin C-terminus HEAT PF02985.22 PIK38286.1 - 0.27 11.6 2.4 39 4.9 0.0 5.1 4 0 0 4 4 4 0 HEAT repeat DUF3385 PF11865.8 PIK38286.1 - 4.1 7.3 7.0 14 5.5 0.1 4.5 4 1 0 4 4 4 0 Domain of unknown function (DUF3385) adh_short PF00106.25 PIK38287.1 - 1.9e-18 66.7 0.1 2.2e-18 66.4 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38287.1 - 8.5e-14 51.7 0.0 1.1e-13 51.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38287.1 - 3.2e-08 33.7 0.1 4.3e-08 33.3 0.1 1.0 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 PIK38287.1 - 0.014 15.2 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus ApbA PF02558.16 PIK38287.1 - 0.016 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Helicase_RecD PF05127.14 PIK38287.1 - 0.021 14.7 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 Helicase 3HCDH_N PF02737.18 PIK38287.1 - 0.034 14.0 0.0 0.043 13.7 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 PIK38287.1 - 0.046 13.6 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 PIK38287.1 - 0.05 13.1 0.0 0.061 12.8 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_tran_WecB PF03808.13 PIK38287.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family TIG PF01833.24 PIK38288.1 - 1.3e-07 31.6 0.2 2.5e-07 30.7 0.1 1.6 2 0 0 2 2 2 1 IPT/TIG domain TIG_plexin PF17960.1 PIK38289.1 - 9e-17 60.9 0.8 1.9e-15 56.6 0.1 2.7 2 0 0 2 2 2 1 TIG domain Sema PF01403.19 PIK38289.1 - 9e-16 57.7 0.2 9e-16 57.7 0.2 1.9 1 1 0 2 2 2 1 Sema domain TIG_2 PF18020.1 PIK38289.1 - 4.8e-10 39.9 1.9 4.7e-09 36.7 0.2 3.0 3 0 0 3 3 3 1 TIG domain found in plexin PSI PF01437.25 PIK38289.1 - 1.3e-09 38.4 30.6 6.3e-08 33.0 11.6 2.9 2 0 0 2 2 2 2 Plexin repeat TIG PF01833.24 PIK38291.1 - 1.1e-33 115.1 9.6 2.3e-10 40.4 0.8 4.3 4 0 0 4 4 4 4 IPT/TIG domain Plexin_cytopl PF08337.12 PIK38291.1 - 0.00037 19.3 0.3 0.0013 17.5 0.1 1.8 2 0 0 2 2 2 1 Plexin cytoplasmic RasGAP domain DUF3377 PF11857.8 PIK38291.1 - 0.089 12.7 0.7 0.22 11.4 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) PSI PF01437.25 PIK38291.1 - 0.11 13.0 8.5 0.29 11.7 8.5 1.7 1 0 0 1 1 1 0 Plexin repeat SKG6 PF08693.10 PIK38291.1 - 8.5 5.9 6.6 14 5.2 6.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sema PF01403.19 PIK38292.1 - 4e-36 124.7 1.2 7.8e-36 123.8 1.2 1.4 1 1 0 1 1 1 1 Sema domain Runt PF00853.19 PIK38292.1 - 0.089 12.3 0.1 0.3 10.6 0.1 1.9 1 0 0 1 1 1 0 Runt domain PQQ_3 PF13570.6 PIK38293.1 - 0.15 12.6 0.6 9.5 6.9 0.0 3.7 4 1 0 4 4 4 0 PQQ-like domain ZU5 PF00791.20 PIK38294.1 - 3.5e-08 33.7 0.0 7.8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain HYR PF02494.16 PIK38295.1 - 3.5e-43 145.8 3.5 4e-25 88.0 0.8 2.0 2 0 0 2 2 2 2 HYR domain DUF5011 PF16403.5 PIK38295.1 - 0.062 13.4 0.1 3 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) HYR PF02494.16 PIK38296.1 - 8e-40 135.0 20.7 2.6e-17 62.9 2.3 3.0 3 0 0 3 3 3 3 HYR domain 7tm_2 PF00002.24 PIK38298.1 - 1.4e-24 86.7 14.7 1.8e-24 86.4 14.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF1201 PF06716.11 PIK38298.1 - 0.038 14.0 2.0 0.038 14.0 2.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1201) DUF3681 PF12442.8 PIK38298.1 - 1.1 9.7 5.4 4.7 7.7 0.2 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3681) EGF PF00008.27 PIK38299.1 - 1.3e-07 31.8 19.3 0.00053 20.2 6.4 2.5 2 0 0 2 2 2 2 EGF-like domain EGF_2 PF07974.13 PIK38299.1 - 1.6e-05 25.2 19.9 0.0091 16.4 13.2 2.4 1 1 1 2 2 2 2 EGF-like domain hEGF PF12661.7 PIK38299.1 - 0.00017 22.1 20.7 0.0073 16.9 5.8 3.6 3 1 0 3 3 3 2 Human growth factor-like EGF EB PF01683.18 PIK38299.1 - 0.045 14.0 16.4 0.87 9.9 4.2 2.5 1 1 1 2 2 2 0 EB module Y_phosphatase PF00102.27 PIK38300.1 - 6.3e-123 408.9 6.2 1.7e-65 220.9 0.5 2.5 3 0 0 3 3 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK38300.1 - 6.9e-10 39.1 3.9 1.2e-05 25.6 0.8 3.3 3 0 0 3 3 3 2 Fibronectin type III domain DSPc PF00782.20 PIK38300.1 - 3.4e-07 30.1 0.1 0.00094 19.0 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK38300.1 - 4.4e-06 26.8 0.0 0.0022 18.0 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family TMEM154 PF15102.6 PIK38300.1 - 0.00016 21.6 0.2 0.00037 20.4 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family PTPlike_phytase PF14566.6 PIK38300.1 - 0.00034 20.7 0.0 0.24 11.5 0.0 3.2 3 0 0 3 3 3 1 Inositol hexakisphosphate RIFIN PF02009.16 PIK38300.1 - 0.0034 17.3 0.5 0.0066 16.4 0.1 1.7 2 0 0 2 2 1 1 Rifin Amnionless PF14828.6 PIK38300.1 - 0.0051 15.7 0.0 0.0084 15.0 0.0 1.2 1 0 0 1 1 1 1 Amnionless DUF2207 PF09972.9 PIK38300.1 - 0.011 14.6 0.4 0.033 13.0 0.2 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Y_phosphatase2 PF03162.13 PIK38300.1 - 0.029 14.0 0.1 0.095 12.3 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF4448 PF14610.6 PIK38300.1 - 0.032 14.0 0.1 0.074 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF5305 PF17231.2 PIK38300.1 - 0.035 13.5 0.4 0.072 12.5 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) SKG6 PF08693.10 PIK38300.1 - 0.047 13.1 10.4 0.082 12.3 10.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Orf78 PF06024.12 PIK38300.1 - 0.047 14.0 0.2 0.12 12.7 0.2 1.6 1 0 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 PIK38300.1 - 0.053 14.4 0.0 0.19 12.6 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CDKN3 PF05706.12 PIK38300.1 - 0.19 11.4 0.5 3.5 7.3 0.0 2.9 3 1 1 4 4 4 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Insulin_TMD PF17870.1 PIK38300.1 - 0.2 11.8 7.1 0.43 10.7 7.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Baculo_11_kDa PF06143.11 PIK38300.1 - 0.3 10.7 3.5 0.75 9.4 3.5 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family GPI-anchored PF10342.9 PIK38300.1 - 0.65 10.8 3.9 1.4 9.7 2.2 2.4 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RVT_1 PF00078.27 PIK38301.1 - 7.9e-19 68.1 0.0 1e-18 67.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GCFC PF07842.12 PIK38302.1 - 0.049 13.2 0.0 0.055 13.1 0.0 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein Glyco_transf_10 PF00852.19 PIK38303.1 - 1.7e-40 138.6 1.2 2e-40 138.4 1.2 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Baculo_ODV-E27 PF05314.11 PIK38303.1 - 0.035 13.3 0.1 0.036 13.2 0.1 1.1 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Transposase_21 PF02992.14 PIK38304.1 - 1.3e-13 50.7 0.1 3.2e-13 49.4 0.1 1.6 1 0 0 1 1 1 1 Transposase family tnp2 DUF1258 PF06869.12 PIK38304.1 - 5.4e-13 49.0 0.7 1e-12 48.1 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1258) ZU5 PF00791.20 PIK38304.1 - 9.2e-13 48.4 0.3 4.3e-12 46.2 0.0 2.3 2 0 0 2 2 2 1 ZU5 domain DUF2064 PF09837.9 PIK38304.1 - 0.18 11.6 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) DED PF01335.21 PIK38304.1 - 0.35 11.2 6.3 1.2 9.5 0.9 3.7 3 0 0 3 3 3 0 Death effector domain BEN PF10523.9 PIK38305.1 - 5.1e-05 23.4 0.0 0.0001 22.5 0.0 1.5 1 0 0 1 1 1 1 BEN domain bZIP_2 PF07716.15 PIK38305.1 - 0.016 15.3 1.8 0.038 14.1 1.8 1.6 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 PIK38305.1 - 0.024 14.7 0.7 0.024 14.7 0.7 1.9 2 0 0 2 2 2 0 bZIP transcription factor Shugoshin_N PF07558.11 PIK38305.1 - 0.041 13.7 0.5 0.084 12.7 0.5 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region ZapB PF06005.12 PIK38305.1 - 0.28 11.7 4.0 0.68 10.4 4.0 1.7 1 1 0 1 1 1 0 Cell division protein ZapB MFS_1 PF07690.16 PIK38306.1 - 5.8e-06 25.5 31.2 0.0025 16.8 13.5 2.4 1 1 0 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 PIK38307.1 - 8.7e-21 73.9 10.2 2.5e-06 28.1 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38307.1 - 1.6e-05 25.1 0.7 0.88 9.9 0.0 5.0 3 2 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK38307.1 - 0.00011 22.2 0.1 0.36 10.7 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK38307.1 - 0.0005 19.1 4.9 0.036 13.0 0.5 3.6 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 PIK38307.1 - 0.0095 14.0 0.0 0.0095 14.0 0.0 2.7 2 1 1 3 3 3 1 IKI3 family DUF2140 PF09911.9 PIK38307.1 - 0.011 15.3 0.2 0.03 13.9 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) LapA_dom PF06305.11 PIK38307.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Neur_chan_LBD PF02931.23 PIK38308.1 - 1.7e-53 181.3 3.2 2.2e-53 180.9 3.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK38308.1 - 4.9e-41 141.4 17.6 6.2e-41 141.0 17.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region YrhC PF14143.6 PIK38308.1 - 2.8 8.1 5.6 7 6.8 5.6 1.6 1 0 0 1 1 1 0 YrhC-like protein Nckap1 PF09735.9 PIK38309.1 - 0 1072.7 14.2 0 1072.5 14.2 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein DUF2688 PF10892.8 PIK38309.1 - 0.053 13.0 0.4 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) Nckap1 PF09735.9 PIK38310.1 - 1.1e-47 162.8 0.8 1.2e-47 162.6 0.8 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein PRAI PF00697.22 PIK38310.1 - 0.023 14.5 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase F-box-like PF12937.7 PIK38311.1 - 5.8e-16 58.1 7.4 4.6e-15 55.2 0.8 3.8 4 0 0 4 4 4 1 F-box-like F-box PF00646.33 PIK38311.1 - 2.8e-10 39.8 11.1 3.4e-10 39.5 0.8 4.4 4 0 0 4 4 4 1 F-box domain LRR_4 PF12799.7 PIK38311.1 - 4.4e-09 36.5 13.6 0.3 11.6 0.1 6.4 6 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK38311.1 - 5.1e-06 26.1 28.3 0.0083 16.1 0.0 11.3 13 0 0 13 13 13 1 Leucine Rich repeat LRR_1 PF00560.33 PIK38311.1 - 0.00019 21.5 15.7 34 5.5 0.0 10.1 11 1 0 11 11 11 0 Leucine Rich Repeat Cdc6_C PF09079.11 PIK38311.1 - 0.0091 16.0 1.1 9.9 6.2 0.0 3.5 4 0 0 4 4 4 2 CDC6, C terminal winged helix domain DUF4194 PF13835.6 PIK38313.1 - 0.073 12.8 0.1 0.53 10.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4194) Ig_3 PF13927.6 PIK38314.1 - 6.7e-06 26.6 2.4 8.8e-06 26.2 0.1 2.3 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK38314.1 - 1.4e-05 25.3 0.0 3.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK38314.1 - 0.00026 21.0 1.1 0.00048 20.1 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_5 PF16681.5 PIK38314.1 - 0.0022 18.4 0.0 0.0043 17.4 0.0 1.5 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain hEGF PF12661.7 PIK38314.1 - 0.0079 16.8 6.8 0.036 14.7 6.8 2.3 1 0 0 1 1 1 1 Human growth factor-like EGF Ig_6 PF18452.1 PIK38314.1 - 0.0091 15.5 0.5 0.025 14.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK38314.1 - 0.02 15.1 0.1 0.02 15.1 0.1 1.8 2 0 0 2 2 2 0 Immunoglobulin domain EGF_2 PF07974.13 PIK38314.1 - 0.51 10.8 18.1 1.3 9.4 18.1 1.8 1 0 0 1 1 1 0 EGF-like domain NADH-G_4Fe-4S_3 PF10588.9 PIK38314.1 - 1.3 8.6 4.1 2.7 7.6 4.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region FeoB_associated PF12669.7 PIK38314.1 - 7.3 7.1 6.7 16 6.0 6.7 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein CUB PF00431.20 PIK38315.1 - 9.6e-13 48.4 0.0 4.4e-07 30.2 0.0 2.2 2 0 0 2 2 2 2 CUB domain AATF-Che1 PF13339.6 PIK38316.1 - 1.6e-30 106.6 3.3 1.6e-30 106.6 3.3 3.9 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 PIK38316.1 - 3.3e-28 98.0 0.5 3.3e-28 98.0 0.5 2.8 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal Glyco_transf_8 PF01501.20 PIK38317.1 - 6.5e-15 55.4 0.0 1.3e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 RF-1 PF00472.20 PIK38318.1 - 1e-17 64.1 3.3 1.6e-17 63.5 3.3 1.3 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 PIK38319.1 - 5.8e-60 202.5 4.3 8.6e-60 201.9 4.3 1.3 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 PIK38319.1 - 3.2e-14 52.9 0.1 3.2e-14 52.9 0.1 2.6 3 0 0 3 3 3 1 RF-1 domain DUF2203 PF09969.9 PIK38319.1 - 0.25 12.1 2.2 0.51 11.1 2.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4208 PF13907.6 PIK38319.1 - 0.31 11.5 2.4 2.5 8.6 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Seryl_tRNA_N PF02403.22 PIK38319.1 - 5.1 7.4 11.0 5.4 7.3 2.9 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Exo_endo_phos PF03372.23 PIK38320.1 - 0.0023 17.5 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38320.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase DUF4198 PF10670.9 PIK38321.1 - 0.052 13.9 0.0 0.057 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) THAP PF05485.12 PIK38322.1 - 3.1e-16 60.1 0.5 4.6e-16 59.5 0.5 1.2 1 0 0 1 1 1 1 THAP domain H_lectin PF09458.10 PIK38322.1 - 0.042 14.0 0.0 0.096 12.9 0.0 1.6 2 0 0 2 2 2 0 H-type lectin domain rve PF00665.26 PIK38324.1 - 1.8e-17 63.6 0.0 2e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK38325.1 - 3.6e-25 87.9 0.0 6.1e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK38325.1 - 6.7e-17 61.4 0.5 1.1e-16 60.6 0.5 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK38325.1 - 1.7e-13 50.8 0.0 3.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK38325.1 - 0.0017 18.6 0.8 0.0037 17.5 0.8 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK38326.1 - 5.2e-18 65.4 0.0 6.8e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_2 PF12756.7 PIK38329.1 - 0.073 13.4 2.0 0.35 11.2 0.3 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK38329.1 - 0.18 12.3 8.1 0.26 11.8 3.1 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK38329.1 - 0.2 12.0 8.5 0.047 14.0 2.8 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Acylphosphatase PF00708.18 PIK38330.1 - 2.7e-08 34.1 0.0 4.1e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Acylphosphatase C2 PF00168.30 PIK38331.1 - 1.3e-22 80.0 0.0 2.6e-22 79.1 0.0 1.4 2 0 0 2 2 2 1 C2 domain Caudo_bapla_RBP PF08931.10 PIK38331.1 - 0.03 13.8 0.0 0.039 13.4 0.0 1.1 1 0 0 1 1 1 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head DUF2574 PF10836.8 PIK38331.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2574) C2 PF00168.30 PIK38332.1 - 5.2e-22 78.1 0.0 4.8e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 C2 domain SoxZ PF08770.11 PIK38332.1 - 0.055 13.2 0.0 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Sulphur oxidation protein SoxZ RVT_1 PF00078.27 PIK38333.1 - 1.2e-18 67.4 0.0 2.6e-14 53.3 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK38333.1 - 0.14 12.1 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein VPS9 PF02204.18 PIK38335.1 - 1.5e-11 44.4 0.1 5e-11 42.7 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF2040 PF09745.9 PIK38336.1 - 3.1e-06 27.2 16.6 3.1e-06 27.2 16.6 4.3 1 1 1 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) ATP_bind_1 PF03029.17 PIK38337.1 - 2e-73 247.2 0.1 2.2e-73 247.0 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 PIK38337.1 - 0.00022 21.8 0.0 0.00036 21.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK38337.1 - 0.0021 18.4 0.0 0.0036 17.7 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_17 PF13207.6 PIK38337.1 - 0.0037 17.7 0.0 0.0095 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK38337.1 - 0.0058 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 PIK38337.1 - 0.0066 16.4 0.0 0.21 11.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 PIK38337.1 - 0.009 16.0 0.0 0.017 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK38337.1 - 0.012 15.8 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK38337.1 - 0.013 15.3 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 PIK38337.1 - 0.021 14.8 0.0 0.055 13.4 0.0 1.7 2 1 1 3 3 3 0 Rad17 P-loop domain CLP1_P PF16575.5 PIK38337.1 - 0.026 14.3 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 PIK38337.1 - 0.039 13.7 0.0 0.068 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK38337.1 - 0.041 13.8 0.0 0.75 9.7 0.0 2.5 3 0 0 3 3 3 0 RsgA GTPase AAA PF00004.29 PIK38337.1 - 0.078 13.4 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 PIK38337.1 - 0.081 12.8 0.1 2.3 8.1 0.0 2.5 2 1 0 2 2 2 0 NTPase ADK PF00406.22 PIK38337.1 - 0.09 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Adenylate kinase AAA_7 PF12775.7 PIK38337.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 PIK38337.1 - 0.11 12.1 0.1 15 5.1 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK38337.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 PIK38337.1 - 0.13 12.7 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 PIK38337.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 PIK38337.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 PIK38337.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 PIK38337.1 - 0.2 11.3 0.0 0.35 10.6 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase AAA_28 PF13521.6 PIK38337.1 - 0.22 11.8 0.0 0.32 11.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 PIK38338.1 - 2.1e-07 31.0 0.0 2.5e-07 30.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Ribosomal_60s PF00428.19 PIK38339.1 - 2.3e-24 85.8 8.6 3e-24 85.4 8.6 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein TRAM_LAG1_CLN8 PF03798.16 PIK38340.1 - 5.3e-29 101.4 21.4 8.3e-29 100.7 21.4 1.2 1 0 0 1 1 1 1 TLC domain Ni_hydr_CYTB PF01292.20 PIK38340.1 - 0.0056 16.3 2.1 0.0056 16.3 2.1 2.1 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 MCU PF04678.13 PIK38340.1 - 0.0074 16.4 0.8 0.27 11.3 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial calcium uniporter DUF1325 PF07039.11 PIK38341.1 - 6e-19 68.4 0.1 1.3e-18 67.3 0.0 1.6 2 0 0 2 2 2 1 SGF29 tudor-like domain ubiquitin PF00240.23 PIK38342.1 - 3.4e-09 36.3 0.5 6.3e-09 35.5 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 PIK38342.1 - 0.0018 18.1 0.6 0.0034 17.2 0.6 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 PIK38342.1 - 0.024 14.7 0.0 0.053 13.6 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ABC_membrane PF00664.23 PIK38343.1 - 6.7e-59 199.8 17.3 6.7e-59 199.8 17.3 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK38343.1 - 1.1e-31 110.2 0.0 2.3e-31 109.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK38343.1 - 5.1e-09 35.9 0.1 1.8e-07 30.8 0.2 1.8 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_membrane_3 PF13748.6 PIK38343.1 - 0.0017 17.6 5.0 0.0035 16.6 5.0 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 PIK38343.1 - 0.0061 16.9 0.3 0.035 14.5 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK38343.1 - 0.027 14.7 0.4 0.43 10.9 0.3 2.6 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 PIK38343.1 - 0.096 12.9 0.8 1 9.6 0.8 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 PIK38343.1 - 0.11 12.3 0.1 1 9.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain A_deamin PF02137.18 PIK38344.1 - 4.3e-61 207.2 0.0 5.4e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 PIK38345.1 - 4.3e-10 40.1 0.8 4.7e-09 36.8 0.2 2.6 2 0 0 2 2 2 1 Double-stranded RNA binding motif NST1 PF13945.6 PIK38345.1 - 1.1 9.4 9.0 2.6 8.1 9.0 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 PIK38345.1 - 2.1 7.0 3.5 2.5 6.8 3.5 1.3 1 0 0 1 1 1 0 Presenilin tRNA-synt_1d PF00750.19 PIK38346.1 - 1.2e-71 241.5 0.5 1.9e-71 240.8 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 PIK38346.1 - 1.8e-23 82.9 0.2 5.5e-23 81.4 0.0 2.0 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Nup54 PF13874.6 PIK38346.1 - 0.0048 17.0 1.7 0.0094 16.1 1.7 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 FlaC_arch PF05377.11 PIK38346.1 - 0.038 14.4 6.0 0.93 9.9 1.7 2.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) tRNA-synt_1e PF01406.19 PIK38346.1 - 0.04 13.3 0.0 0.083 12.2 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DivIC PF04977.15 PIK38346.1 - 0.075 12.8 7.4 2.2 8.1 1.9 2.5 1 1 1 2 2 2 0 Septum formation initiator bZIP_2 PF07716.15 PIK38346.1 - 0.1 12.7 4.1 7.3 6.8 0.9 2.6 2 0 0 2 2 2 0 Basic region leucine zipper DUF1515 PF07439.11 PIK38346.1 - 0.1 12.6 0.7 19 5.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) Med9 PF07544.13 PIK38346.1 - 0.12 12.4 7.1 0.57 10.3 3.0 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 VGPC1_C PF16799.5 PIK38346.1 - 0.33 11.0 5.1 0.11 12.5 1.6 2.1 2 0 0 2 2 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF2203 PF09969.9 PIK38346.1 - 0.52 11.0 2.5 1.5 9.6 2.5 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Mto2_bdg PF12808.7 PIK38346.1 - 0.73 10.2 2.9 0.7 10.2 0.7 2.0 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_1 PF00170.21 PIK38346.1 - 0.88 9.7 6.1 12 6.1 0.4 2.6 2 0 0 2 2 2 0 bZIP transcription factor SlyX PF04102.12 PIK38346.1 - 1.4 9.6 4.3 74 4.1 4.3 2.7 1 1 0 1 1 1 0 SlyX XhlA PF10779.9 PIK38346.1 - 1.4 9.2 7.1 0.81 9.9 0.9 2.6 1 1 1 2 2 2 0 Haemolysin XhlA TMF_DNA_bd PF12329.8 PIK38346.1 - 1.7 8.7 10.7 3.7 7.6 2.7 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 PIK38346.1 - 3.6 7.7 5.2 23 5.0 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 PIK38346.1 - 4.4 8.0 8.0 4.1e+02 1.7 8.3 2.6 1 1 0 1 1 1 0 Initiation control protein YabA tRNA-synt_1d PF00750.19 PIK38347.1 - 2.1e-47 161.8 0.0 2.9e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 PIK38347.1 - 1e-30 106.4 0.0 1.5e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 DALR anticodon binding domain RAMA PF18755.1 PIK38347.1 - 0.16 12.4 0.2 29 5.1 0.0 2.3 2 0 0 2 2 2 0 Restriction Enzyme Adenine Methylase Associated Laminin_G_2 PF02210.24 PIK38349.1 - 3.6e-37 127.7 2.1 4.8e-20 72.4 0.1 3.1 3 0 0 3 3 3 2 Laminin G domain Cadherin PF00028.17 PIK38349.1 - 1.7e-36 124.5 5.7 1.3e-18 67.2 0.6 4.2 5 0 0 5 5 5 2 Cadherin domain Laminin_G_1 PF00054.23 PIK38349.1 - 3.8e-29 101.5 0.0 9.8e-19 67.9 0.0 3.3 3 0 0 3 3 3 2 Laminin G domain EGF PF00008.27 PIK38349.1 - 2.6e-22 78.8 84.0 2.1e-07 31.1 8.4 7.5 7 0 0 7 7 7 6 EGF-like domain hEGF PF12661.7 PIK38349.1 - 1.1e-09 38.5 66.2 1.4e-05 25.5 5.3 7.2 7 0 0 7 7 6 4 Human growth factor-like EGF Cadherin_4 PF17803.1 PIK38349.1 - 8.8e-05 23.1 11.2 0.037 14.6 1.5 3.5 3 0 0 3 3 2 2 Bacterial cadherin-like domain Orf78 PF06024.12 PIK38349.1 - 0.0027 18.0 0.0 0.0055 17.0 0.0 1.4 1 0 0 1 1 1 1 Orf78 (ac78) EphA2_TM PF14575.6 PIK38349.1 - 0.012 16.5 0.0 0.031 15.2 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_2 PF08266.12 PIK38349.1 - 0.023 14.5 0.0 4.6 7.2 0.0 2.6 2 0 0 2 2 2 0 Cadherin-like Big_9 PF17963.1 PIK38349.1 - 0.077 13.8 16.9 0.33 11.7 1.0 4.1 5 1 0 5 5 3 0 Bacterial Ig domain DUF4115 PF13464.6 PIK38349.1 - 0.079 13.2 0.0 0.46 10.7 0.0 2.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4115) Baculo_11_kDa PF06143.11 PIK38349.1 - 0.092 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family ECSCR PF15820.5 PIK38349.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator RIFIN PF02009.16 PIK38349.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Rifin Stevor PF17410.2 PIK38349.1 - 0.23 11.0 0.0 0.38 10.2 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cadherin PF00028.17 PIK38350.1 - 1e-44 150.9 1.5 1.9e-20 73.1 0.1 3.1 3 0 0 3 3 3 3 Cadherin domain Cadherin_2 PF08266.12 PIK38350.1 - 1.1e-05 25.2 0.0 0.077 12.8 0.0 3.1 3 0 0 3 3 3 2 Cadherin-like Big_9 PF17963.1 PIK38350.1 - 0.0015 19.2 10.7 0.018 15.8 3.5 3.2 3 0 0 3 3 3 2 Bacterial Ig domain Cadherin PF00028.17 PIK38351.1 - 6.4e-91 299.0 8.0 4.1e-21 75.2 0.4 6.1 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 PIK38351.1 - 4.4e-15 55.3 0.1 0.0033 17.2 0.0 6.3 6 0 0 6 6 6 4 Cadherin-like Cadherin_pro PF08758.11 PIK38351.1 - 0.00037 20.6 0.0 0.054 13.7 0.0 3.6 4 0 0 4 4 4 1 Cadherin prodomain like P2_Phage_GpR PF06891.11 PIK38351.1 - 0.037 14.1 0.2 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 P2 phage tail completion protein R (GpR) Cadherin_4 PF17803.1 PIK38351.1 - 0.22 12.2 28.8 1.4 9.6 3.9 5.0 4 1 0 4 4 4 0 Bacterial cadherin-like domain Cadherin PF00028.17 PIK38352.1 - 9.7e-36 122.1 0.7 3.9e-17 62.5 0.1 2.1 2 0 0 2 2 2 2 Cadherin domain Cadherin-like PF12733.7 PIK38352.1 - 0.012 16.1 4.0 1.4 9.5 0.9 2.3 2 0 0 2 2 2 0 Cadherin-like beta sandwich domain SusE PF14292.6 PIK38352.1 - 0.65 10.2 4.0 15 5.9 0.3 2.5 1 1 0 2 2 2 0 SusE outer membrane protein Cadherin PF00028.17 PIK38353.1 - 9.7e-42 141.3 2.6 9.3e-20 70.9 0.2 3.1 3 0 0 3 3 3 3 Cadherin domain Cadherin_3 PF16184.5 PIK38353.1 - 1.3e-09 38.0 5.0 9.4e-06 25.6 0.1 3.4 3 1 0 3 3 3 3 Cadherin-like Cadherin_4 PF17803.1 PIK38353.1 - 4.5e-07 30.4 21.0 0.012 16.3 0.4 3.3 3 0 0 3 3 3 3 Bacterial cadherin-like domain Cadherin_2 PF08266.12 PIK38353.1 - 0.051 13.4 0.0 5.5 6.9 0.0 2.7 2 1 0 2 2 2 0 Cadherin-like Lyase_1 PF00206.20 PIK38354.1 - 3.2e-46 158.2 0.0 3.4e-46 158.1 0.0 1.0 1 0 0 1 1 1 1 Lyase Fringe PF02434.16 PIK38355.1 - 1.7e-57 194.7 0.2 8e-49 166.3 0.1 2.2 2 0 0 2 2 2 2 Fringe-like Galactosyl_T PF01762.21 PIK38355.1 - 6.7e-05 22.8 1.0 0.51 10.1 0.0 3.6 3 1 1 4 4 4 2 Galactosyltransferase Glycos_transf_2 PF00535.26 PIK38355.1 - 0.0017 18.2 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 PIK38355.1 - 0.074 12.9 0.1 3.5 7.5 0.1 2.2 1 1 0 2 2 2 0 Glycosyltransferase like family 2 AAA_11 PF13086.6 PIK38356.1 - 1.3e-12 48.1 0.0 2.2e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK38356.1 - 8.7e-08 32.6 0.0 2.2e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK38356.1 - 4.3e-05 22.9 0.0 6.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 PIK38356.1 - 9.9e-05 22.4 0.0 0.00022 21.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 PIK38356.1 - 0.00046 20.0 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 PIK38356.1 - 0.00066 19.5 0.1 0.0021 17.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 PIK38356.1 - 0.0046 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 PIK38356.1 - 0.0062 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.6 PIK38356.1 - 0.0074 16.6 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK38356.1 - 0.019 14.6 0.0 0.069 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK38356.1 - 0.023 15.1 0.1 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 PIK38356.1 - 0.046 14.1 0.0 0.15 12.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 PIK38356.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_12 PF13087.6 PIK38357.1 - 1.8e-25 89.7 0.3 3e-18 66.2 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.6 PIK38357.1 - 1.4e-10 41.4 0.1 3.2e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain FMO-like PF00743.19 PIK38358.1 - 3.2e-158 527.4 0.0 3.9e-158 527.2 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK38358.1 - 8.1e-20 71.3 0.0 5e-16 58.8 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK38358.1 - 1.5e-13 50.7 0.0 6.2e-13 48.6 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK38358.1 - 3.3e-08 33.1 0.1 5.5e-07 29.1 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK38358.1 - 3.7e-05 23.9 0.0 8.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK38358.1 - 0.0047 16.2 0.0 0.74 9.0 0.0 2.5 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 PIK38358.1 - 0.02 15.4 3.8 0.12 12.9 0.0 3.5 5 0 0 5 5 5 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK38358.1 - 0.12 11.0 0.0 0.9 8.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 PIK38358.1 - 0.15 11.3 0.0 6 6.1 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PP-binding PF00550.25 PIK38359.1 - 1.3e-07 31.8 0.1 2.6e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hemocyanin_M PF00372.19 PIK38360.1 - 0.0077 15.4 0.3 0.054 12.7 0.0 1.9 1 1 1 2 2 2 1 Hemocyanin, copper containing domain ketoacyl-synt PF00109.26 PIK38361.1 - 3.3e-81 272.6 0.0 6.2e-81 271.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 PIK38361.1 - 4.6e-57 193.9 0.0 6.4e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 PIK38361.1 - 6.2e-33 113.3 0.4 2e-32 111.7 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 PIK38361.1 - 1.8e-14 54.2 0.0 3.4e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension SAT PF16073.5 PIK38361.1 - 0.005 16.6 0.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis DUF1191 PF06697.12 PIK38361.1 - 0.019 14.8 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Thiolase_N PF00108.23 PIK38361.1 - 0.069 12.5 0.1 0.18 11.2 0.1 1.7 1 0 0 1 1 1 0 Thiolase, N-terminal domain Prefoldin_2 PF01920.20 PIK38362.1 - 2.9e-20 72.2 17.5 3.7e-20 71.9 17.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit Cas_Cas6 PF01881.16 PIK38362.1 - 0.0024 18.4 1.4 0.0027 18.3 0.7 1.4 1 1 0 1 1 1 1 CRISPR associated protein Cas6 ADIP PF11559.8 PIK38362.1 - 0.015 15.3 2.5 0.015 15.3 2.5 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 PIK38362.1 - 0.021 14.9 2.6 0.021 14.9 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) XhlA PF10779.9 PIK38362.1 - 0.041 14.1 1.2 0.041 14.1 1.2 2.4 2 1 0 2 2 2 0 Haemolysin XhlA Prefoldin PF02996.17 PIK38362.1 - 0.17 11.8 13.6 5.2 7.0 13.6 2.6 1 1 0 1 1 1 0 Prefoldin subunit DUF3584 PF12128.8 PIK38362.1 - 0.5 7.8 14.7 0.58 7.6 14.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Fib_alpha PF08702.10 PIK38362.1 - 1.2 9.3 9.2 3.4 7.8 9.2 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF2203 PF09969.9 PIK38362.1 - 1.3 9.7 6.2 2.3 9.0 5.8 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 PIK38362.1 - 1.7 7.9 8.6 2.1 7.6 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 PIK38362.1 - 2.8 8.4 6.8 0.8 10.1 0.3 2.9 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Syntaxin_2 PF14523.6 PIK38362.1 - 3.3 8.1 15.3 0.82 10.1 6.2 2.3 1 1 1 2 2 2 0 Syntaxin-like protein IZUMO PF15005.6 PIK38362.1 - 3.3 8.2 8.3 9 6.8 8.2 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Nup88 PF10168.9 PIK38362.1 - 4 5.1 12.1 5.1 4.8 12.1 1.2 1 1 0 1 1 1 0 Nuclear pore component KxDL PF10241.9 PIK38362.1 - 5.7 7.3 13.3 0.95 9.8 5.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein XkdW PF09636.10 PIK38362.1 - 7.1 6.8 8.8 4.8 7.3 1.5 2.2 1 1 0 2 2 2 0 XkdW protein SURF1 PF02104.15 PIK38363.1 - 1.1e-37 129.9 0.1 1.4e-37 129.7 0.1 1.0 1 0 0 1 1 1 1 SURF1 family TPR_MLP1_2 PF07926.12 PIK38364.1 - 0.0069 16.4 10.7 0.0069 16.4 10.7 6.3 1 1 5 6 6 6 4 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 PIK38364.1 - 0.033 12.8 66.1 0.05 12.2 13.5 3.1 1 1 2 3 3 3 0 AAA domain ATG16 PF08614.11 PIK38364.1 - 1.2 9.3 105.9 0.25 11.5 31.2 5.9 2 1 2 5 5 5 0 Autophagy protein 16 (ATG16) Peptidase_C1 PF00112.23 PIK38365.1 - 3.3e-43 148.3 10.8 4.4e-43 147.9 10.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 PIK38365.1 - 0.038 12.8 0.3 0.11 11.3 0.5 1.6 2 0 0 2 2 2 0 Peptidase C1-like family zf-RING_2 PF13639.6 PIK38366.1 - 2.6e-11 43.7 8.2 2.6e-11 43.7 8.2 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK38366.1 - 5.1e-09 35.8 7.5 1.1e-08 34.8 7.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) G2BR PF18442.1 PIK38366.1 - 1.1e-07 31.3 5.3 2.6e-07 30.2 5.3 1.6 1 0 0 1 1 1 1 E3 gp78 Ube2g2-binding region (G2BR) zf-C3HC4 PF00097.25 PIK38366.1 - 1.3e-07 31.3 7.0 2.5e-07 30.5 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK38366.1 - 7.4e-07 28.9 4.2 1.3e-06 28.1 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK38366.1 - 1.3e-06 28.0 1.5 1.3e-06 28.0 1.5 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 PIK38366.1 - 4.8e-06 26.5 3.1 1.1e-05 25.3 3.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK38366.1 - 3.5e-05 23.6 6.0 6.3e-05 22.8 6.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK38366.1 - 3.5e-05 24.0 9.9 3.5e-05 24.0 9.9 2.4 2 1 0 2 2 1 1 RING-H2 zinc finger domain CUE PF02845.16 PIK38366.1 - 4.4e-05 23.1 0.1 8.2e-05 22.2 0.1 1.5 1 0 0 1 1 1 1 CUE domain zf-RING_5 PF14634.6 PIK38366.1 - 0.00057 19.8 6.1 0.001 19.0 6.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK38366.1 - 0.0023 18.0 3.5 0.007 16.4 3.5 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 PIK38366.1 - 0.0029 17.2 5.7 0.0091 15.6 5.7 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 PIK38366.1 - 0.37 10.9 3.9 0.54 10.4 2.5 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger FANCL_C PF11793.8 PIK38366.1 - 2.7 8.2 7.7 14 5.9 7.7 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 PIK38366.1 - 2.8 8.1 9.3 6.3 7.0 9.3 1.6 1 0 0 1 1 1 0 RING-variant domain zf-P11 PF03854.14 PIK38366.1 - 3 7.6 5.6 8.3 6.2 5.6 1.8 1 0 0 1 1 1 0 P-11 zinc finger zf-C3H2C3 PF17122.5 PIK38366.1 - 3.3 7.8 5.3 6.7 6.8 5.3 1.6 1 0 0 1 1 1 0 Zinc-finger Ctr PF04145.15 PIK38367.1 - 0.057 14.0 0.1 0.86 10.2 0.0 2.3 2 0 0 2 2 2 0 Ctr copper transporter family CxC5 PF18718.1 PIK38367.1 - 0.073 13.2 0.3 0.13 12.3 0.3 1.3 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases Abhydrolase_6 PF12697.7 PIK38368.1 - 5e-19 69.8 0.2 6.5e-19 69.4 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 PIK38368.1 - 1e-18 68.0 0.1 4.5e-18 65.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK38368.1 - 2.2e-12 46.8 0.0 3.1e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 PIK38368.1 - 0.0032 16.0 0.0 0.0066 15.0 0.0 1.4 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Esterase PF00756.20 PIK38368.1 - 0.0044 16.7 0.0 0.0071 16.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 PIK38368.1 - 0.013 15.4 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK38368.1 - 0.019 14.4 0.0 0.085 12.3 0.0 2.0 3 0 0 3 3 3 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 PIK38368.1 - 0.027 13.4 0.0 0.053 12.4 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Thioesterase PF00975.20 PIK38368.1 - 0.046 13.8 0.0 0.077 13.1 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain LIDHydrolase PF10230.9 PIK38368.1 - 0.056 13.0 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 PIK38368.1 - 0.15 11.9 0.0 14 5.4 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase MatE PF01554.18 PIK38369.1 - 2.4e-23 82.5 13.3 2.4e-23 82.5 13.3 1.6 2 0 0 2 2 2 1 MatE MatE PF01554.18 PIK38371.1 - 3.8e-10 39.6 1.3 3.8e-10 39.6 1.3 1.5 2 0 0 2 2 2 1 MatE zf-C2H2 PF00096.26 PIK38372.1 - 6.1e-27 92.5 32.0 3.4e-06 27.2 1.8 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK38372.1 - 6.3e-21 73.8 29.6 1e-07 32.0 0.1 5.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK38372.1 - 1.8e-20 71.8 31.4 8.6e-05 23.1 0.1 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK38372.1 - 2.7e-09 36.8 25.9 0.0011 18.9 1.2 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK38372.1 - 3e-07 30.5 15.8 0.039 14.2 0.2 5.1 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK38372.1 - 6.7e-07 29.5 21.7 0.0017 18.6 1.5 3.4 2 1 1 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 PIK38372.1 - 7.9e-06 25.5 22.5 0.16 11.8 0.8 5.3 4 1 1 5 5 5 3 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 PIK38372.1 - 4.9e-05 23.7 7.6 1.9 9.0 0.0 4.9 4 0 0 4 4 4 2 Autophagy receptor zinc finger-C2H2 domain zinc_ribbon_9 PF14369.6 PIK38372.1 - 0.0028 17.9 14.0 4.4 7.7 0.1 5.3 5 0 0 5 5 5 1 zinc-ribbon zf_UBZ PF18439.1 PIK38372.1 - 0.0053 16.3 16.4 0.97 9.1 0.1 5.3 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger Rpr2 PF04032.16 PIK38372.1 - 0.02 15.2 12.3 1.9 8.9 7.8 2.6 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain FYDLN_acid PF09538.10 PIK38372.1 - 0.029 15.1 8.8 5.1 7.8 1.1 4.2 2 2 2 4 4 4 0 Protein of unknown function (FYDLN_acid) zf-met PF12874.7 PIK38372.1 - 0.07 13.5 21.5 1.1 9.7 0.3 5.0 5 0 0 5 5 5 0 Zinc-finger of C2H2 type HypA PF01155.19 PIK38372.1 - 0.13 12.3 16.5 0.68 10.0 1.4 3.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-LYAR PF08790.11 PIK38372.1 - 0.23 11.4 6.3 6.9 6.7 0.0 3.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.5 PIK38372.1 - 0.28 11.9 20.0 0.15 12.8 0.8 3.1 1 1 2 3 3 3 0 zinc-ribbon family zinc_ribbon_4 PF13717.6 PIK38372.1 - 0.48 10.4 21.8 7.2 6.6 0.1 4.9 4 1 0 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 PIK38372.1 - 0.81 9.9 24.2 4.2 7.6 4.6 4.2 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_9 PF16293.5 PIK38372.1 - 1.1 9.2 10.2 8.5 6.3 0.1 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF4428 PF14471.6 PIK38372.1 - 1.3 9.1 7.6 4.8 7.2 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) ADK_lid PF05191.14 PIK38372.1 - 1.9 8.6 19.7 2.4 8.2 1.0 3.9 3 0 0 3 3 3 0 Adenylate kinase, active site lid CpXC PF14353.6 PIK38372.1 - 2.3 8.3 16.2 3.4 7.7 0.1 4.2 2 2 1 3 3 3 0 CpXC protein zf-BED PF02892.15 PIK38372.1 - 2.9 8.0 28.8 8.5 6.5 0.7 5.2 1 1 2 4 4 4 0 BED zinc finger zf-H2C2_5 PF13909.6 PIK38372.1 - 3.4 7.5 28.0 0.88 9.4 1.8 5.8 4 2 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 PIK38372.1 - 4.1 7.9 21.9 1.9 9.0 0.2 5.0 1 1 3 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger FYVE PF01363.21 PIK38372.1 - 5 7.3 23.1 1e+02 3.1 18.1 3.4 1 1 1 2 2 2 0 FYVE zinc finger FOXP-CC PF16159.5 PIK38372.1 - 8 7.2 9.7 28 5.4 0.8 3.4 2 1 1 3 3 3 0 FOXP coiled-coil domain PWWP PF00855.17 PIK38373.1 - 2.4e-13 50.3 0.3 2.4e-13 50.3 0.3 4.9 3 2 0 3 3 3 1 PWWP domain zf-CW PF07496.15 PIK38373.1 - 3.9e-13 49.2 7.3 1.5e-12 47.3 7.3 2.1 1 0 0 1 1 1 1 CW-type Zinc Finger Acyl_transf_1 PF00698.21 PIK38374.1 - 7.9e-11 42.0 0.0 1.4e-10 41.2 0.0 1.3 1 1 0 1 1 1 1 Acyl transferase domain RT_RNaseH_2 PF17919.1 PIK38375.1 - 3.4e-33 113.7 0.1 7.5e-33 112.6 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38375.1 - 6e-28 97.2 0.0 1.1e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38375.1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK38375.1 - 0.066 13.3 0.1 0.21 11.7 0.1 2.0 1 0 0 1 1 1 0 Integrase zinc binding domain Pico_P2B PF01552.17 PIK38375.1 - 0.067 13.4 0.6 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Picornavirus 2B protein EMI PF07546.13 PIK38376.1 - 3.4e-10 40.5 16.4 5.3e-10 39.9 16.4 1.3 1 0 0 1 1 1 1 EMI domain Ank_2 PF12796.7 PIK38377.1 - 1.5e-23 83.2 1.2 1.5e-12 47.9 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK38377.1 - 4.5e-13 49.4 0.4 2.9e-05 24.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK38377.1 - 5.7e-12 45.5 2.3 7.6e-05 23.0 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK38377.1 - 4e-10 39.1 0.1 0.00083 19.6 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 PIK38377.1 - 3.9e-08 33.4 0.1 2.2e-05 24.7 0.0 2.9 1 1 3 4 4 4 2 Ankyrin repeats (many copies) p450 PF00067.22 PIK38378.1 - 1.5e-39 136.1 0.0 5.9e-29 101.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 WD40 PF00400.32 PIK38380.1 - 1.3e-18 67.0 6.9 1.8e-07 31.7 0.1 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38380.1 - 1.2e-05 25.5 0.3 5.1 7.5 0.0 3.6 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK38380.1 - 0.00027 19.7 0.7 0.0026 16.5 0.1 2.2 1 1 1 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK38380.1 - 0.00035 20.0 1.3 0.0086 15.4 1.2 2.1 1 1 1 2 2 2 1 WD40-like domain Nucleoporin_N PF08801.11 PIK38380.1 - 0.098 11.4 0.3 0.32 9.7 0.0 1.8 1 1 0 2 2 2 0 Nup133 N terminal like DEAD PF00270.29 PIK38381.1 - 4.4e-41 140.6 0.1 8.2e-41 139.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK38381.1 - 7.6e-29 100.3 0.2 1.9e-26 92.5 0.1 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 PIK38381.1 - 0.0055 17.0 1.3 0.02 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 PIK38381.1 - 0.035 14.1 0.0 0.035 14.1 0.0 3.4 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit Linker_histone PF00538.19 PIK38382.1 - 3.5e-21 75.4 0.7 3.5e-21 75.4 0.7 2.7 2 1 1 3 3 3 1 linker histone H1 and H5 family DUF2486 PF10667.9 PIK38382.1 - 0.21 11.8 17.0 0.29 11.3 17.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) SLC12 PF03522.15 PIK38382.1 - 0.4 9.7 13.6 0.44 9.5 13.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 PIK38382.1 - 1.9 7.2 8.3 2.2 7.0 8.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein adh_short PF00106.25 PIK38383.1 - 2.8e-52 177.0 0.5 3.3e-52 176.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38383.1 - 5.7e-36 124.2 0.3 7.2e-36 123.9 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38383.1 - 3.1e-08 33.7 0.1 4.7e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK38383.1 - 0.0021 17.5 0.3 0.01 15.3 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 PIK38383.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UCH PF00443.29 PIK38384.1 - 1.1e-57 195.5 0.1 1.4e-57 195.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK38384.1 - 7.9e-20 71.7 0.4 1.6e-18 67.4 0.4 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 PIK38384.1 - 1.5e-05 24.6 3.6 0.0038 16.7 0.1 3.2 3 0 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase zf-UBP PF02148.19 PIK38384.1 - 0.034 14.5 0.2 0.034 14.5 0.2 2.9 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein Olduvai PF06758.13 PIK38384.1 - 0.14 12.5 2.3 0.49 10.7 2.3 1.9 1 0 0 1 1 1 0 Olduvai domain Integrase_H2C2 PF17921.1 PIK38385.1 - 3e-15 56.1 5.2 3.1e-15 56.0 2.7 2.2 1 1 1 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK38385.1 - 5.9e-11 42.6 0.0 1.1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK38385.1 - 0.0013 18.7 0.2 0.004 17.2 0.2 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38386.1 - 4.8e-41 140.7 0.1 6e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SH3_1 PF00018.28 PIK38387.1 - 3.4e-19 68.2 0.0 4.8e-19 67.7 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK38387.1 - 2.7e-14 52.8 0.0 4.6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK38387.1 - 3.5e-13 49.0 0.0 5.6e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH2 PF00017.24 PIK38387.1 - 4.2e-05 23.6 0.0 7.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_10 PF17902.1 PIK38387.1 - 0.00064 19.7 0.0 0.00082 19.4 0.0 1.4 1 1 0 1 1 1 1 SH3 domain BRAP2 PF07576.12 PIK38387.1 - 0.012 15.8 0.0 0.019 15.2 0.0 1.2 1 0 0 1 1 1 0 BRCA1-associated protein 2 DUF5093 PF17011.5 PIK38387.1 - 0.013 15.8 0.1 0.014 15.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) Vps62 PF06101.11 PIK38388.1 - 1.2e-20 73.4 0.0 4.2e-11 41.8 0.0 2.1 1 1 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 Aerolysin PF01117.20 PIK38388.1 - 2.1e-06 27.2 1.9 3.8e-06 26.4 1.9 1.3 1 0 0 1 1 1 1 Aerolysin toxin ETX_MTX2 PF03318.13 PIK38388.1 - 3.3e-05 23.8 3.5 5.5e-05 23.0 3.5 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 ETX_MTX2 PF03318.13 PIK38389.1 - 0.0034 17.2 0.9 0.0052 16.6 0.9 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK38389.1 - 0.0078 15.5 0.2 0.0099 15.1 0.2 1.1 1 0 0 1 1 1 1 Aerolysin toxin Autotransporter PF03797.19 PIK38389.1 - 0.036 13.7 0.3 0.052 13.2 0.3 1.4 1 1 0 1 1 1 0 Autotransporter beta-domain Lactamase_B_4 PF13691.6 PIK38390.1 - 1.5e-18 66.2 0.0 2.1e-16 59.3 0.0 2.9 2 0 0 2 2 2 2 tRNase Z endonuclease Lactamase_B_2 PF12706.7 PIK38390.1 - 7e-17 61.6 0.0 2.2e-15 56.7 0.1 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 PIK38390.1 - 0.062 13.3 0.0 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Neur_chan_memb PF02932.16 PIK38393.1 - 9.4e-16 58.6 0.1 1.2e-15 58.3 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK38393.1 - 2.1e-05 24.1 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DeoC PF01791.9 PIK38394.1 - 2.8e-26 92.6 0.1 3.4e-26 92.3 0.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase C2 PF00168.30 PIK38395.1 - 2.1e-42 143.6 0.7 2.2e-23 82.5 0.0 2.8 2 1 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 PIK38395.1 - 2.9e-07 30.5 0.1 0.0046 16.9 0.0 2.8 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 DOCK-C2 PF14429.6 PIK38395.1 - 0.00093 19.1 0.5 0.027 14.3 0.1 2.3 1 1 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF1494 PF07379.11 PIK38395.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1494) Cupin_8 PF13621.6 PIK38396.1 - 1.9e-10 40.9 0.0 2.1e-09 37.5 0.0 2.0 1 1 1 2 2 2 2 Cupin-like domain JmjC PF02373.22 PIK38396.1 - 0.034 14.6 0.0 0.076 13.5 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase EF-hand_7 PF13499.6 PIK38398.1 - 0.12 12.8 0.3 0.32 11.5 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair NGF PF00243.18 PIK38399.1 - 9.4e-30 103.2 5.1 1.3e-29 102.7 5.1 1.1 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 PIK38399.1 - 0.0019 18.7 0.4 0.0027 18.2 0.4 1.2 1 0 0 1 1 1 1 Spaetzle DSPc PF00782.20 PIK38400.1 - 1.9e-22 79.5 0.0 3.1e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Raftlin PF15250.6 PIK38403.1 - 0.094 11.5 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Raftlin Phage_integrase PF00589.22 PIK38405.1 - 0.0037 17.1 0.0 0.0086 15.9 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family I-set PF07679.16 PIK38406.1 - 4.4e-56 186.9 0.0 3.1e-12 46.4 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK38406.1 - 1.7e-52 175.9 9.3 3.5e-14 53.2 0.0 8.0 7 1 1 8 8 8 5 Immunoglobulin domain fn3 PF00041.21 PIK38406.1 - 8.6e-47 157.4 12.7 1.2e-13 51.2 0.2 4.8 4 0 0 4 4 4 4 Fibronectin type III domain Ig_2 PF13895.6 PIK38406.1 - 4.9e-40 135.7 5.6 4.6e-10 39.7 0.0 7.1 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.25 PIK38406.1 - 3e-28 97.8 15.5 7.8e-08 32.4 0.0 7.4 8 0 0 8 8 8 6 Immunoglobulin domain V-set PF07686.17 PIK38406.1 - 3.9e-20 72.1 11.1 0.00036 20.7 0.0 9.9 7 3 2 9 9 9 6 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK38406.1 - 1.1e-10 41.0 0.0 0.37 10.4 0.0 5.5 5 0 0 5 5 5 3 Immunoglobulin domain Interfer-bind PF09294.10 PIK38406.1 - 3.6e-10 40.1 0.1 0.019 15.2 0.0 4.4 4 0 0 4 4 4 3 Interferon-alpha/beta receptor, fibronectin type III Ig_5 PF16681.5 PIK38406.1 - 9.5e-07 29.1 0.8 0.22 12.0 0.0 5.5 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.5 PIK38406.1 - 5.8e-06 26.8 13.2 0.17 12.5 0.3 5.2 3 1 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 PIK38406.1 - 2.8e-05 24.1 1.2 34 4.6 0.0 6.1 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK38406.1 - 9.2e-05 22.4 0.7 9.3 6.4 0.0 5.2 5 0 0 5 5 5 1 C17orf99 Ig domain Ig_4 PF16680.5 PIK38406.1 - 0.00012 22.3 2.8 5.4 7.3 0.0 5.7 6 0 0 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Tissue_fac PF01108.17 PIK38406.1 - 0.0003 20.6 1.7 0.083 12.7 0.0 4.0 4 0 0 4 4 4 1 Tissue factor C2-set_2 PF08205.12 PIK38406.1 - 0.023 14.7 0.8 26 5.0 0.0 4.2 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 PIK38406.1 - 0.059 13.6 1.2 14 5.9 0.0 3.8 5 0 0 5 5 3 0 Immunoglobulin C2-set domain Adeno_E3_CR1 PF02440.15 PIK38406.1 - 0.11 12.3 0.0 11 5.9 0.0 3.4 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 I-set PF07679.16 PIK38407.1 - 1.4e-12 47.5 0.1 3e-07 30.4 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK38407.1 - 4.2e-11 43.3 2.5 0.00039 21.0 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK38407.1 - 1.2e-06 28.6 0.2 0.35 11.1 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK38407.1 - 4.4e-06 26.9 1.8 0.012 15.9 0.0 3.7 3 1 1 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK38407.1 - 8.7e-05 22.7 0.1 0.00047 20.3 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK38407.1 - 0.00032 20.6 0.0 0.00096 19.1 0.0 1.8 1 1 0 1 1 1 1 TMEM154 protein family C2-set_2 PF08205.12 PIK38407.1 - 0.00047 20.2 3.0 0.73 9.9 0.0 3.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain LapA_dom PF06305.11 PIK38407.1 - 0.019 14.7 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2207 PF09972.9 PIK38407.1 - 0.035 12.9 0.0 0.074 11.8 0.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Baculo_11_kDa PF06143.11 PIK38407.1 - 0.036 13.6 0.0 0.084 12.5 0.0 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4834 PF16118.5 PIK38407.1 - 0.048 14.6 0.0 0.095 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) YukC PF10140.9 PIK38407.1 - 0.051 12.4 0.0 0.08 11.8 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC PRIMA1 PF16101.5 PIK38407.1 - 0.057 13.4 1.2 0.22 11.6 0.0 2.4 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Protocadherin PF08374.11 PIK38407.1 - 0.064 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protocadherin EphA2_TM PF14575.6 PIK38407.1 - 0.08 13.8 0.0 0.2 12.5 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 PIK38407.1 - 0.11 11.3 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF3169 PF11368.8 PIK38407.1 - 0.11 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Orf78 PF06024.12 PIK38407.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) SCIMP PF15050.6 PIK38407.1 - 0.14 12.6 0.0 0.5 10.8 0.0 1.9 1 1 1 2 2 2 0 SCIMP protein Adeno_E3_CR2 PF02439.15 PIK38407.1 - 0.2 11.4 2.1 0.39 10.5 2.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ABC_membrane PF00664.23 PIK38408.1 - 3.3e-59 200.8 36.5 1.3e-46 159.5 15.2 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 PIK38408.1 - 2.5e-48 164.1 1.6 2.1e-27 96.3 0.0 3.4 4 0 0 4 4 3 2 ABC transporter SMC_N PF02463.19 PIK38408.1 - 2.9e-11 43.2 0.0 0.0019 17.7 0.0 3.6 1 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 PIK38408.1 - 3.2e-06 27.2 3.2 0.69 9.7 0.1 4.4 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK38408.1 - 2.8e-05 23.8 2.6 0.029 14.1 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 PIK38408.1 - 0.00047 20.1 0.4 0.043 13.7 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 PIK38408.1 - 0.00061 20.2 0.0 0.14 12.6 0.0 3.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 PIK38408.1 - 0.00075 19.1 0.2 0.32 10.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 PIK38408.1 - 0.00077 19.5 0.4 1.5 8.9 0.2 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK38408.1 - 0.0012 18.9 3.6 0.0033 17.5 0.0 2.7 3 0 0 3 3 2 1 Dynamin family AAA_7 PF12775.7 PIK38408.1 - 0.0048 16.4 0.3 0.85 9.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK38408.1 - 0.014 15.7 2.2 4 7.7 0.1 3.0 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 PIK38408.1 - 0.015 14.5 0.2 0.091 12.0 0.1 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 PIK38408.1 - 0.02 14.6 4.0 0.7 9.5 0.0 3.1 4 0 0 4 4 4 0 AAA ATPase domain AAA_24 PF13479.6 PIK38408.1 - 0.039 13.7 1.7 0.28 10.9 0.1 2.6 2 1 0 2 2 2 0 AAA domain WBP-1 PF11669.8 PIK38408.1 - 0.088 13.4 0.6 0.53 10.9 0.6 2.3 1 0 0 1 1 1 0 WW domain-binding protein 1 T2SSE PF00437.20 PIK38408.1 - 0.12 11.4 0.1 18 4.3 0.0 2.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 PIK38408.1 - 0.14 12.4 1.0 8.6 6.6 0.1 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 PIK38408.1 - 0.21 10.9 1.6 11 5.2 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.6 PIK38408.1 - 0.36 11.3 9.3 3.9 7.9 0.0 3.5 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 PIK38408.1 - 0.69 10.0 4.9 1.3 9.0 0.1 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain SelR PF01641.18 PIK38409.1 - 7.4e-54 181.0 1.2 8.7e-54 180.8 1.2 1.0 1 0 0 1 1 1 1 SelR domain DUF2797 PF10977.8 PIK38409.1 - 0.027 14.4 1.1 0.089 12.7 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2797) zf-ribbon_3 PF13248.6 PIK38409.1 - 0.029 13.8 1.9 4.5 6.8 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Yippee-Mis18 PF03226.14 PIK38409.1 - 0.052 13.7 0.3 0.12 12.6 0.3 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DpnI PF06044.12 PIK38409.1 - 0.067 12.8 0.9 3.4 7.3 0.1 2.3 2 1 0 2 2 2 0 Dam-replacing family DZR PF12773.7 PIK38409.1 - 0.084 12.9 1.7 11 6.1 0.0 2.5 2 1 1 3 3 3 0 Double zinc ribbon Auto_anti-p27 PF06677.12 PIK38409.1 - 0.37 11.0 2.5 5.8 7.2 0.1 2.6 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Pkinase PF00069.25 PIK38411.1 - 1e-41 143.1 0.0 1.8e-41 142.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38411.1 - 4.2e-18 65.6 0.0 6.3e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 PIK38411.1 - 3.3e-11 43.7 2.1 3.3e-11 43.7 2.1 2.2 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 PIK38411.1 - 4.6e-05 22.9 0.0 0.00011 21.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK38411.1 - 7.7e-05 21.6 0.0 0.00013 20.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK38411.1 - 0.032 13.6 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK38411.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 PIK38412.1 - 6e-23 80.7 12.7 1.4e-05 25.8 0.0 6.0 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38412.1 - 2.5e-14 53.3 0.1 0.0045 17.2 0.0 5.3 2 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK38412.1 - 9.8e-12 44.5 0.0 0.0027 16.7 0.0 4.8 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK38412.1 - 4.5e-06 26.7 0.0 0.028 14.3 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK38412.1 - 4.3e-05 22.4 0.0 0.037 12.7 0.0 2.4 2 0 0 2 2 2 2 Nucleoporin Nup120/160 SOCS_box PF07525.16 PIK38412.1 - 0.00023 21.5 1.1 0.0006 20.1 1.1 1.7 1 0 0 1 1 1 1 SOCS box Nbas_N PF15492.6 PIK38412.1 - 0.033 13.5 0.1 1.7 7.9 0.0 3.2 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal AvrE_T3Es PF11725.8 PIK38412.1 - 0.29 8.3 0.0 0.38 7.9 0.0 1.0 1 0 0 1 1 1 0 AvrE-family Type-III effector proteins (T3Es) Septin PF00735.18 PIK38413.1 - 4.1e-114 380.6 0.8 5e-114 380.3 0.8 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 PIK38413.1 - 6.6e-09 35.8 0.4 1.6e-08 34.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK38413.1 - 3.2e-07 30.4 0.2 1.3e-05 25.2 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 PIK38413.1 - 1.3e-05 24.6 0.1 1.3e-05 24.6 0.1 1.7 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 PIK38413.1 - 0.00043 19.9 0.1 0.0013 18.4 0.1 1.9 1 1 0 1 1 1 1 Ras family AAA_16 PF13191.6 PIK38413.1 - 0.00082 19.8 0.0 0.0015 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 PIK38413.1 - 0.0027 17.3 2.2 0.15 11.6 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 PIK38413.1 - 0.0034 17.9 0.1 0.0086 16.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 PIK38413.1 - 0.0063 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 PIK38413.1 - 0.0079 16.5 0.1 0.036 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 PIK38413.1 - 0.012 16.1 3.5 0.05 14.1 3.5 1.8 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 PIK38413.1 - 0.02 14.8 0.3 6.3 6.7 0.0 2.8 2 1 1 3 3 3 0 Rad17 P-loop domain AAA_7 PF12775.7 PIK38413.1 - 0.022 14.3 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 PIK38413.1 - 0.03 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pox_A32 PF04665.12 PIK38413.1 - 0.068 12.6 0.1 0.14 11.6 0.1 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 PIK38413.1 - 0.11 12.3 1.8 0.18 11.5 0.1 2.2 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK38413.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Dynamin_N PF00350.23 PIK38413.1 - 0.26 11.3 8.5 1.9 8.5 0.4 3.1 2 1 1 3 3 3 0 Dynamin family SET PF00856.28 PIK38414.1 - 5e-22 79.1 2.9 6e-22 78.8 1.1 2.0 2 1 0 2 2 2 1 SET domain N-SET PF11764.8 PIK38414.1 - 6.8e-14 52.3 0.8 1.1e-13 51.6 0.8 1.3 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N RRM_9 PF18444.1 PIK38414.1 - 0.086 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif RRM_1 PF00076.22 PIK38415.1 - 7.2e-10 38.6 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK38415.1 - 0.067 13.1 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif Macoilin PF09726.9 PIK38415.1 - 5.5 5.4 8.9 7.6 5.0 8.9 1.2 1 0 0 1 1 1 0 Macoilin family PIH1 PF08190.12 PIK38416.1 - 0.027 14.0 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 PIH1 N-terminal domain DUF3410 PF11890.8 PIK38416.1 - 0.044 13.6 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) RVT_1 PF00078.27 PIK38418.1 - 5.7e-41 140.5 3.5 1e-40 139.6 0.4 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK38418.1 - 5.8e-08 33.3 0.3 3.8e-07 30.7 0.1 2.4 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Exo_endo_phos_2 PF14529.6 PIK38418.1 - 0.0004 20.2 0.6 0.0013 18.6 0.6 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK38418.1 - 0.017 14.6 0.1 0.048 13.2 0.1 1.7 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Tropomodulin PF03250.14 PIK38419.1 - 1e-12 48.3 1.5 1.8e-11 44.3 0.2 2.6 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.6 PIK38419.1 - 2.6e-06 27.0 5.6 0.013 15.5 0.0 4.0 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 PIK38419.1 - 0.0011 19.4 3.3 0.019 15.4 0.2 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) FumaraseC_C PF10415.9 PIK38419.1 - 0.0051 17.2 0.8 0.39 11.2 0.0 3.5 2 1 1 3 3 3 1 Fumarase C C-terminus LRR_1 PF00560.33 PIK38419.1 - 0.036 14.6 0.0 5.5 7.9 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich Repeat STI1 PF17830.1 PIK38419.1 - 0.48 10.4 6.4 4 7.4 0.3 3.7 4 0 0 4 4 4 0 STI1 domain PY_rept_46 PF09689.10 PIK38419.1 - 0.85 10.2 4.7 7.9 7.1 1.1 3.1 3 0 0 3 3 3 0 Plasmodium yoelii repeat (PY_rept_46) Cullin PF00888.22 PIK38420.1 - 6.1e-193 642.8 22.0 6.1e-193 642.8 22.0 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 PIK38420.1 - 2.2e-27 94.9 11.2 1.6e-26 92.1 5.1 3.7 3 0 0 3 3 3 1 Cullin protein neddylation domain Phage_TAC_12 PF12363.8 PIK38420.1 - 0.018 15.4 0.7 0.078 13.4 0.1 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC L27_1 PF09058.10 PIK38420.1 - 0.029 14.3 1.5 3 7.9 0.0 3.8 2 0 0 2 2 2 0 L27_1 LcrG PF07216.12 PIK38420.1 - 0.11 12.4 2.5 2 8.4 0.1 3.2 3 0 0 3 3 3 0 LcrG protein PGK PF00162.19 PIK38420.1 - 0.18 10.7 1.5 0.4 9.6 1.5 1.5 1 0 0 1 1 1 0 Phosphoglycerate kinase Kazal_2 PF07648.15 PIK38421.1 - 0.00097 19.2 3.1 0.0016 18.5 3.1 1.4 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK38421.1 - 0.03 14.3 1.7 0.044 13.8 1.7 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Complex1_LYR_2 PF13233.6 PIK38422.1 - 2.1e-17 63.6 0.9 2.9e-17 63.2 0.8 1.3 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 PIK38422.1 - 4.3e-07 29.9 0.4 6.7e-07 29.3 0.4 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF1340 PF07067.11 PIK38422.1 - 6.6e-05 22.4 0.2 7.5e-05 22.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1340) Cupin_8 PF13621.6 PIK38423.1 - 5.2e-38 131.2 0.1 8.3e-38 130.5 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK38423.1 - 2.2e-10 40.5 0.2 7.1e-10 38.8 0.2 1.6 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 PIK38423.1 - 2.5e-07 31.1 0.3 7.2e-07 29.6 0.3 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 PIK38423.1 - 0.02 14.6 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Methyltransf_23 PF13489.6 PIK38424.1 - 3.4e-11 43.3 0.0 5.8e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK38424.1 - 1.7e-05 25.5 0.0 6.2e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK38424.1 - 6.9e-05 23.5 0.0 0.00013 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK38424.1 - 0.00098 19.7 0.0 0.0079 16.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK38424.1 - 0.097 12.5 0.0 0.24 11.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Peptidase_C1 PF00112.23 PIK38425.1 - 4.3e-85 285.2 4.0 5.1e-85 285.0 4.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 PIK38425.1 - 0.00022 20.1 2.4 0.027 13.3 0.8 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Peptidase_C1 PF00112.23 PIK38426.1 - 1.9e-54 185.0 2.3 2.6e-51 174.8 0.5 2.1 1 1 1 2 2 2 2 Papain family cysteine protease Peptidase_C1_2 PF03051.15 PIK38426.1 - 0.00041 19.2 1.0 0.0007 18.5 1.0 1.3 1 0 0 1 1 1 1 Peptidase C1-like family Zip PF02535.22 PIK38429.1 - 9.6e-57 192.7 11.3 1.1e-56 192.5 11.3 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter EF-hand_6 PF13405.6 PIK38430.1 - 0.0066 16.3 0.1 0.048 13.6 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 PIK38430.1 - 0.0099 15.4 0.5 0.05 13.2 0.0 2.2 2 1 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK38430.1 - 0.019 15.4 0.4 0.17 12.3 0.5 2.0 1 1 1 2 2 2 0 EF-hand domain pair DUF1266 PF06889.11 PIK38430.1 - 0.021 14.9 0.1 0.027 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) Collagen PF01391.18 PIK38430.1 - 0.54 10.1 4.5 1.4 8.8 4.5 1.7 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Rad17 PF03215.15 PIK38432.1 - 3.1e-42 144.6 0.1 4.9e-42 144.0 0.1 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 PIK38432.1 - 1.5e-05 25.4 0.0 2.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_assoc_2 PF16193.5 PIK38432.1 - 0.00035 20.8 0.0 0.0008 19.7 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 PIK38432.1 - 0.00081 19.8 0.1 0.002 18.6 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK38432.1 - 0.0033 17.7 0.0 0.011 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 PIK38432.1 - 0.0087 15.7 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain RuvB_N PF05496.12 PIK38432.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK38432.1 - 0.028 14.4 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 PIK38432.1 - 0.03 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 PIK38432.1 - 0.033 14.2 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 PIK38432.1 - 0.034 13.7 0.2 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 PIK38432.1 - 0.039 14.4 0.0 0.13 12.7 0.0 2.1 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 PIK38432.1 - 0.039 14.5 0.0 0.088 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK38432.1 - 0.062 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 PIK38432.1 - 0.092 12.1 0.0 0.87 9.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 PIK38432.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK38432.1 - 0.12 12.3 0.3 0.78 9.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain WD40 PF00400.32 PIK38433.1 - 1.1e-20 73.6 16.6 6.6e-08 33.1 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38433.1 - 7.3e-05 23.0 0.2 0.049 13.9 0.0 3.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IL17 PF06083.11 PIK38434.1 - 2.8e-24 85.4 1.8 5.3e-24 84.5 1.8 1.4 1 0 0 1 1 1 1 Interleukin-17 Glyco_tran_10_N PF17039.5 PIK38435.1 - 1.3e-10 41.7 0.1 2e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal EGF_CA PF07645.15 PIK38437.1 - 1.6e-106 348.3 315.5 4.5e-10 39.6 7.4 21.4 20 2 1 21 21 21 16 Calcium-binding EGF domain cEGF PF12662.7 PIK38437.1 - 1.8e-38 130.1 180.1 7.6e-07 28.9 1.3 22.4 22 1 0 22 22 22 14 Complement Clr-like EGF-like EGF PF00008.27 PIK38437.1 - 3.1e-28 97.7 271.6 6.8e-05 23.1 6.1 21.2 20 0 0 20 20 20 16 EGF-like domain FXa_inhibition PF14670.6 PIK38437.1 - 5.8e-28 96.9 278.6 0.0024 18.1 6.3 20.9 18 2 2 20 20 20 16 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK38437.1 - 4.7e-25 87.5 249.5 0.00036 20.7 4.1 21.8 20 1 1 21 21 21 15 EGF domain TB PF00683.17 PIK38437.1 - 3.2e-15 55.6 14.4 6.1e-11 41.9 6.4 4.2 2 0 0 2 2 2 2 TB domain hEGF PF12661.7 PIK38437.1 - 7.5e-11 42.3 279.4 0.025 15.2 7.9 22.4 22 0 0 22 22 22 14 Human growth factor-like EGF EGF_2 PF07974.13 PIK38437.1 - 0.0042 17.4 22.5 0.0083 16.5 8.2 21.5 20 1 1 21 21 21 11 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK38437.1 - 0.0058 16.9 3.0 0.0058 16.9 3.0 20.4 18 1 2 20 20 20 9 Pvs28 EGF domain UPF0669 PF17065.5 PIK38438.1 - 4.7e-41 140.6 0.8 1.1e-40 139.4 0.8 1.5 1 1 0 1 1 1 1 Putative cytokine, C6ORF120 PPC PF04151.15 PIK38438.1 - 0.019 16.1 0.2 0.034 15.2 0.2 1.4 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain Ank_2 PF12796.7 PIK38439.1 - 1.9e-36 124.5 4.6 6.5e-07 29.9 0.0 7.0 7 1 0 7 7 7 5 Ankyrin repeats (3 copies) PARP PF00644.20 PIK38439.1 - 5.2e-29 101.2 0.0 4.3e-28 98.2 0.0 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Ank_4 PF13637.6 PIK38439.1 - 4.8e-27 94.0 6.4 0.0019 18.8 0.0 10.2 6 2 4 10 10 10 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK38439.1 - 3.5e-24 84.5 7.8 7.9e-06 26.0 0.3 8.7 7 3 2 9 9 9 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK38439.1 - 3.6e-24 84.1 13.1 2.7e-06 27.5 0.0 10.9 10 1 0 10 10 10 5 Ankyrin repeat Ank_3 PF13606.6 PIK38439.1 - 4.7e-21 72.6 8.9 0.13 12.9 0.0 11.3 11 0 0 11 11 11 6 Ankyrin repeat PARP_reg PF02877.14 PIK38439.1 - 4.4e-15 56.0 1.8 9.9e-15 54.8 1.8 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 PIK38439.1 - 8e-15 54.7 0.4 2.1e-14 53.3 0.4 1.8 1 0 0 1 1 1 1 WGR domain Ank_2 PF12796.7 PIK38440.1 - 7.9e-41 138.5 3.7 3e-12 46.9 0.0 6.2 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK38440.1 - 1.1e-29 102.4 5.2 2.4e-05 24.8 0.0 9.1 3 3 7 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK38440.1 - 3.1e-27 94.3 8.1 0.00036 20.8 0.0 8.7 6 2 2 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK38440.1 - 8e-26 87.3 7.1 0.0019 18.5 0.0 10.7 11 0 0 11 11 11 5 Ankyrin repeat Ank PF00023.30 PIK38440.1 - 3.5e-22 77.8 15.4 0.00073 19.9 0.0 9.0 9 0 0 9 9 9 6 Ankyrin repeat PYC_OADA PF02436.18 PIK38442.1 - 3.3e-62 209.8 0.0 4e-62 209.5 0.0 1.0 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_D2 PF02786.17 PIK38443.1 - 4.7e-63 212.5 0.0 6.6e-63 212.0 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 PIK38443.1 - 1.1e-16 60.8 0.1 4.1e-13 49.4 0.0 2.4 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 PIK38443.1 - 5.8e-11 42.4 0.0 3.9e-09 36.5 0.0 2.4 2 0 0 2 2 2 1 HMGL-like Dala_Dala_lig_C PF07478.13 PIK38443.1 - 9.8e-05 22.0 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 PIK38443.1 - 0.0024 17.5 0.1 0.0044 16.6 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 PIK38443.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.5 1 1 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 PIK38443.1 - 0.2 11.7 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Biotin_carb_N PF00289.22 PIK38444.1 - 5.8e-43 145.9 0.0 8.2e-43 145.4 0.0 1.2 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain V-set PF07686.17 PIK38445.1 - 1.3e-08 34.9 0.1 3.5e-07 30.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK38445.1 - 4.5e-05 24.0 0.2 0.0007 20.2 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK38445.1 - 8.1e-05 22.6 0.1 0.0011 19.0 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin I-set domain RVT_1 PF00078.27 PIK38446.1 - 8.4e-20 71.2 0.0 9.4e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK38446.1 - 0.066 13.2 0.0 0.07 13.1 0.0 1.1 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Lectin_C PF00059.21 PIK38450.1 - 1.7e-14 54.4 7.1 1.9e-14 54.3 6.0 1.6 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK38450.1 - 1.1e-07 31.7 0.0 1.7e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK38451.1 - 3.3e-14 53.5 6.7 6.6e-14 52.5 6.7 1.5 1 1 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK38452.1 - 9.6e-10 39.2 1.2 1.2e-09 38.8 1.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK38453.1 - 1.7e-10 41.6 3.5 1.9e-10 41.5 3.5 1.0 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK38454.1 - 5.3e-09 36.8 0.3 5.8e-09 36.7 0.3 1.0 1 0 0 1 1 1 1 Lectin C-type domain MPC PF03650.13 PIK38455.1 - 1.8e-39 134.3 0.1 2.5e-39 133.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers OTCace PF00185.24 PIK38456.1 - 1.1e-51 175.0 0.0 1.5e-51 174.6 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 PIK38456.1 - 3.9e-43 147.0 0.0 5.6e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain NAD_binding_10 PF13460.6 PIK38457.1 - 8.4e-42 143.1 0.0 9.7e-42 142.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK38457.1 - 6.9e-11 42.1 0.1 1.1e-10 41.4 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK38457.1 - 1.4e-06 28.0 0.0 2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 PIK38457.1 - 0.035 13.2 0.1 0.065 12.3 0.0 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain Semialdhyde_dh PF01118.24 PIK38457.1 - 0.037 14.5 0.2 0.081 13.4 0.2 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SurE PF01975.17 PIK38457.1 - 0.04 13.7 0.0 0.069 12.9 0.0 1.4 1 1 0 1 1 1 0 Survival protein SurE OSTMP1 PF09777.9 PIK38458.1 - 7.4e-40 136.8 17.2 9.4e-40 136.5 17.2 1.1 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor DZR PF12773.7 PIK38458.1 - 0.085 12.9 0.3 0.085 12.9 0.3 3.5 2 2 0 2 2 2 0 Double zinc ribbon NuA4 PF09340.10 PIK38459.1 - 3.5e-25 87.7 1.2 3.5e-25 87.7 1.2 2.3 2 1 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Hormone_recep PF00104.30 PIK38460.1 - 8.9e-16 58.1 0.0 1.3e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor WD40 PF00400.32 PIK38461.1 - 1e-33 114.8 8.3 5e-06 27.2 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38461.1 - 1.4e-10 41.4 0.5 0.084 13.2 0.0 5.1 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK38461.1 - 0.021 14.7 0.9 2 8.2 0.0 2.6 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A CUB PF00431.20 PIK38462.1 - 2.1e-70 234.0 0.0 1.2e-15 57.8 0.0 5.2 5 0 0 5 5 5 5 CUB domain CUB_2 PF02408.20 PIK38462.1 - 0.0017 18.1 0.0 39 4.0 0.0 4.2 4 0 0 4 4 4 3 CUB-like domain CAP_N PF01213.19 PIK38463.1 - 9.8e-108 360.4 0.7 9.8e-108 360.4 0.7 1.4 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 PIK38463.1 - 1.6e-48 164.3 7.4 1.6e-47 161.1 7.4 2.1 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 PIK38463.1 - 0.044 13.5 1.1 0.076 12.8 1.1 1.3 1 0 0 1 1 1 0 Tubulin binding cofactor C PfkB PF00294.24 PIK38464.1 - 4.5e-10 39.3 0.0 5e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase WD40 PF00400.32 PIK38465.1 - 1.3e-15 57.5 5.7 4.8e-06 27.2 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38465.1 - 1.7e-10 41.0 0.0 0.0057 16.9 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SGL PF08450.12 PIK38465.1 - 0.017 14.7 0.0 0.06 12.9 0.0 1.9 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Coatomer_WDAD PF04053.14 PIK38465.1 - 0.13 11.3 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Ge1_WD40 PF16529.5 PIK38465.1 - 0.14 11.1 0.0 3.2 6.6 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein UDPGT PF00201.18 PIK38466.1 - 8.1e-37 127.2 0.1 8.9e-37 127.0 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase RepA_N PF06970.11 PIK38466.1 - 0.07 13.1 0.0 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 Replication initiator protein A (RepA) N-terminus Fibrinogen_C PF00147.18 PIK38467.1 - 2.8e-93 311.8 19.6 1.6e-49 168.7 7.8 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK38467.1 - 8.5e-05 22.7 9.4 8.5e-05 22.7 9.4 3.4 2 1 1 3 3 3 1 EGF domain TILa PF12714.7 PIK38467.1 - 0.00011 22.1 3.5 0.00011 22.1 3.5 2.8 3 0 0 3 3 3 1 TILa domain EGF_2 PF07974.13 PIK38467.1 - 0.32 11.4 12.5 0.18 12.2 5.9 3.4 2 2 0 2 2 2 0 EGF-like domain DUF4391 PF14335.6 PIK38468.1 - 0.003 17.3 0.1 0.005 16.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4391) Methyltransf_34 PF11312.8 PIK38468.1 - 0.021 14.1 0.1 0.34 10.1 0.1 2.1 1 1 0 1 1 1 0 Putative SAM-dependent methyltransferase Ssl1 PF04056.14 PIK38468.1 - 0.047 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Ssl1-like NiFe_hyd_SSU_C PF14720.6 PIK38468.1 - 0.33 11.3 2.1 0.66 10.4 2.1 1.5 1 0 0 1 1 1 0 NiFe/NiFeSe hydrogenase small subunit C-terminal DisA-linker PF10635.9 PIK38469.1 - 0.074 12.8 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region DUF4391 PF14335.6 PIK38469.1 - 0.09 12.5 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Fibrinogen_C PF00147.18 PIK38473.1 - 3.9e-35 121.6 0.1 5.6e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38473.1 - 1.1e-06 28.8 16.8 1.1e-06 28.8 16.8 1.9 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain RhoGAP PF00620.27 PIK38475.1 - 3.8e-34 117.7 0.0 1.9e-20 73.3 0.0 2.1 2 0 0 2 2 2 2 RhoGAP domain ATP-synt_ab PF00006.25 PIK38476.1 - 1.6e-62 210.9 0.0 2.3e-62 210.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 PIK38476.1 - 4.3e-22 78.4 1.0 9.1e-22 77.4 1.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase_2 PF01637.18 PIK38476.1 - 0.006 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 PIK38476.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 PIK38476.1 - 0.015 14.5 0.1 0.031 13.5 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 PIK38476.1 - 0.047 14.1 0.1 0.4 11.0 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 PIK38476.1 - 0.054 13.9 0.2 1.7 9.1 0.0 3.1 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) T3SS_ATPase_C PF18269.1 PIK38476.1 - 0.061 13.2 0.5 0.29 11.0 0.5 2.0 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain ATPase PF06745.13 PIK38476.1 - 0.093 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 PIK38476.1 - 0.1 12.1 0.5 2.6 7.6 0.3 2.5 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 PIK38476.1 - 0.1 12.9 0.6 0.28 11.5 0.2 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 PIK38476.1 - 0.15 12.6 0.0 0.38 11.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter DUF4709 PF15821.5 PIK38477.1 - 4e-39 133.3 5.5 4e-39 133.3 5.5 5.0 2 1 3 5 5 5 1 Domain of unknown function (DUF4709) GramPos_pilinBB PF16569.5 PIK38477.1 - 0.15 12.9 1.0 0.32 11.8 0.1 2.1 2 0 0 2 2 2 0 Gram-positive pilin backbone subunit 2, Cna-B-like domain RACo_linker PF17650.1 PIK38477.1 - 0.24 11.3 6.1 0.12 12.2 0.4 3.1 3 0 0 3 3 3 0 RACo linker region PGA_cap PF09587.10 PIK38477.1 - 9.7 5.6 9.5 0.77 9.2 0.6 2.6 1 1 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap Actin PF00022.19 PIK38478.1 - 4.5e-150 499.8 0.0 1.6e-149 498.0 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 PIK38478.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain WBP-1 PF11669.8 PIK38479.1 - 0.0005 20.7 3.7 0.0005 20.7 3.7 2.3 3 0 0 3 3 3 1 WW domain-binding protein 1 TRAM_2 PF18693.1 PIK38479.1 - 0.0065 16.6 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 TRAM domain GTP_EFTU PF00009.27 PIK38480.1 - 1.1e-41 142.6 0.0 1.5e-41 142.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 PIK38480.1 - 5.2e-38 130.4 10.1 9e-38 129.6 10.1 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 PIK38480.1 - 1.7e-25 89.2 0.0 4.6e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 PIK38480.1 - 2.2e-23 82.1 0.0 7.4e-23 80.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 PIK38480.1 - 2.9e-14 53.2 0.0 5.5e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 PIK38480.1 - 5.4e-06 26.4 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Luciferase_N PF05295.11 PIK38480.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain rve PF00665.26 PIK38481.1 - 4.1e-23 81.8 0.0 6.5e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK38481.1 - 8.9e-09 35.0 0.0 1.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 PIK38481.1 - 0.031 14.4 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RIIa PF02197.17 PIK38482.1 - 6.3e-05 22.5 0.9 0.00012 21.7 0.9 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit MapZ_C2 PF18708.1 PIK38482.1 - 0.14 12.5 0.1 0.36 11.2 0.0 1.7 1 1 0 1 1 1 0 MapZ extracellular C-terminal domain 2 Endonuclease_NS PF01223.23 PIK38483.1 - 2.6e-24 86.3 0.0 2.8e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclease_NS PF01223.23 PIK38484.1 - 1.2e-58 198.6 0.0 1.5e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Exog_C PF18026.1 PIK38484.1 - 3.4e-13 49.4 0.4 7.2e-13 48.4 0.4 1.5 1 0 0 1 1 1 1 Endo/exonuclease (EXOG) C-terminal domain Avl9 PF09794.9 PIK38485.1 - 1.2e-69 234.9 0.0 3.1e-69 233.5 0.0 1.6 1 1 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 PIK38485.1 - 3.6e-11 43.0 0.3 0.00027 20.9 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 PIK38485.1 - 0.00013 21.6 4.7 0.00025 20.8 0.1 2.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 PIK38485.1 - 0.029 14.3 0.2 0.064 13.2 0.2 1.5 1 0 0 1 1 1 0 DENN (AEX-3) domain TMF_TATA_bd PF12325.8 PIK38486.1 - 0.0097 16.1 4.3 0.024 14.8 4.3 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding LemA PF04011.12 PIK38486.1 - 0.05 13.4 0.9 0.091 12.6 0.9 1.3 1 0 0 1 1 1 0 LemA family Seryl_tRNA_N PF02403.22 PIK38486.1 - 0.09 13.0 4.5 0.17 12.2 4.5 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain AATF-Che1 PF13339.6 PIK38486.1 - 0.14 12.8 8.2 0.4 11.4 7.9 2.0 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor eIF3_N PF09440.10 PIK38486.1 - 0.19 12.2 1.1 0.32 11.4 1.1 1.4 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain RasGAP_C PF03836.15 PIK38486.1 - 0.35 11.0 3.5 1.7 8.8 3.5 2.1 1 1 0 1 1 1 0 RasGAP C-terminus Macoilin PF09726.9 PIK38486.1 - 0.63 8.5 12.1 0.9 8.0 12.1 1.3 1 0 0 1 1 1 0 Macoilin family TUDOR PF00567.24 PIK38487.1 - 2.2e-51 173.0 0.3 1.8e-24 86.1 0.1 3.3 2 1 1 3 3 3 3 Tudor domain Agenet PF05641.12 PIK38487.1 - 0.21 12.1 1.8 4.9 7.7 0.7 2.5 2 0 0 2 2 2 0 Agenet domain Ank_2 PF12796.7 PIK38488.1 - 4.7e-12 46.3 2.8 4.6e-07 30.3 0.4 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ion_trans PF00520.31 PIK38488.1 - 1.4e-07 31.0 26.6 2.1e-07 30.4 26.6 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_5 PF13857.6 PIK38488.1 - 5.5e-07 29.7 1.2 0.3 11.5 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK38488.1 - 7e-06 26.0 2.1 0.0064 16.9 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 PIK38488.1 - 0.00062 20.1 1.4 0.0066 16.8 0.1 3.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 PIK38488.1 - 0.0014 19.2 1.7 0.24 12.0 0.0 3.7 3 1 1 4 4 4 1 Ankyrin repeats (many copies) DUF4549 PF15082.6 PIK38489.1 - 4.9e-64 214.4 2.4 1e-63 213.3 2.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4549) SRA1 PF07304.11 PIK38490.1 - 0.0037 17.1 1.1 0.0083 15.9 0.1 2.1 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Tup_N PF08581.10 PIK38490.1 - 0.24 11.7 4.0 1.3 9.4 1.0 3.1 2 0 0 2 2 2 0 Tup N-terminal DUF5094 PF17015.5 PIK38490.1 - 9.4 6.3 10.6 0.15 12.2 1.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5094) SSP160 PF06933.11 PIK38492.1 - 0.14 10.3 8.6 0.18 10.0 8.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF563 PF04577.14 PIK38493.1 - 3.4e-19 69.8 0.0 5.1e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) MFS_1 PF07690.16 PIK38494.1 - 1.1e-14 54.1 14.2 1.5e-14 53.7 14.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily RVT_1 PF00078.27 PIK38495.1 - 3.4e-33 115.0 0.1 5e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK38495.1 - 1.3e-06 27.9 0.0 3.9e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) Exo_endo_phos_2 PF14529.6 PIK38496.1 - 6.6e-10 38.9 0.2 2.2e-09 37.2 0.2 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK38496.1 - 8e-10 38.6 0.2 1.3e-09 37.9 0.2 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family adh_short PF00106.25 PIK38497.1 - 1e-49 168.7 0.0 1.3e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38497.1 - 1.4e-28 100.0 0.0 2e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38497.1 - 3.3e-09 36.9 0.0 5e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK38497.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ApbA PF02558.16 PIK38497.1 - 0.01 15.5 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF3890 PF13029.6 PIK38497.1 - 0.017 15.5 0.1 0.042 14.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3890) 3HCDH_N PF02737.18 PIK38497.1 - 0.078 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 PIK38497.1 - 0.16 11.4 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sulfotransfer_2 PF03567.14 PIK38498.1 - 1e-15 58.4 1.7 1.4e-15 57.9 1.7 1.1 1 0 0 1 1 1 1 Sulfotransferase family DUF3834 PF12916.7 PIK38498.1 - 0.27 10.4 1.1 0.42 9.8 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) MCM PF00493.23 PIK38499.1 - 3.8e-87 291.1 0.0 6e-87 290.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK38499.1 - 3.6e-36 123.8 0.1 7.9e-36 122.7 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK38499.1 - 1e-22 80.4 1.5 3e-22 78.8 1.5 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 PIK38499.1 - 1.4e-09 38.5 2.4 1.8e-09 38.1 0.3 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 PIK38499.1 - 6.3e-08 32.2 0.1 2.5e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 PIK38499.1 - 0.00029 20.7 0.0 0.0011 18.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK38499.1 - 0.0018 18.3 0.0 0.0067 16.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 PIK38499.1 - 0.019 14.7 0.0 0.054 13.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF948 PF06103.11 PIK38501.1 - 0.00061 20.0 29.9 0.19 12.0 10.6 4.0 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 PIK38501.1 - 0.00063 20.2 14.4 0.042 14.3 6.0 2.3 1 1 1 2 2 2 2 Spectrin repeat AIP3 PF03915.13 PIK38501.1 - 0.0011 18.2 9.8 0.0014 17.8 9.8 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 Syntaxin PF00804.25 PIK38501.1 - 0.0011 18.7 15.5 0.024 14.3 9.0 2.3 1 1 1 2 2 2 2 Syntaxin HOOK PF05622.12 PIK38501.1 - 0.0011 17.2 10.2 0.0014 16.9 10.2 1.1 1 0 0 1 1 1 1 HOOK protein DUF16 PF01519.16 PIK38501.1 - 0.0018 18.7 20.1 0.75 10.3 2.2 3.2 1 1 1 2 2 2 1 Protein of unknown function DUF16 Spc7 PF08317.11 PIK38501.1 - 0.0033 16.4 17.7 0.0051 15.7 17.7 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3540 PF12059.8 PIK38501.1 - 0.012 15.5 8.6 0.017 15.0 4.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3540) Syntaxin-6_N PF09177.11 PIK38501.1 - 0.027 15.0 19.2 1.1 9.9 10.3 3.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal ATG16 PF08614.11 PIK38501.1 - 0.05 13.8 17.1 0.093 12.9 16.1 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) MCPsignal PF00015.21 PIK38501.1 - 0.1 12.4 31.2 0.56 10.0 19.0 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain WXG100 PF06013.12 PIK38501.1 - 0.1 12.8 7.0 0.45 10.8 3.3 2.7 1 1 0 2 2 2 0 Proteins of 100 residues with WXG DUF3450 PF11932.8 PIK38501.1 - 0.12 11.7 17.0 0.11 11.8 9.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 PIK38501.1 - 0.13 12.3 14.9 26 4.9 14.7 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 PIK38501.1 - 0.15 12.3 20.3 0.91 9.8 11.4 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 DUF1798 PF08807.10 PIK38501.1 - 0.15 12.2 7.1 0.37 10.9 2.9 2.4 1 1 1 2 2 2 0 Bacterial domain of unknown function (DUF1798) Laminin_II PF06009.12 PIK38501.1 - 0.18 11.8 20.2 0.26 11.3 5.8 2.9 1 1 1 2 2 2 0 Laminin Domain II KxDL PF10241.9 PIK38501.1 - 0.19 12.1 7.3 5.2 7.4 0.1 3.1 1 1 2 3 3 2 0 Uncharacterized conserved protein DUF3584 PF12128.8 PIK38501.1 - 0.2 9.1 15.6 0.26 8.7 15.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.9 PIK38501.1 - 0.29 10.1 22.7 0.6 9.0 17.1 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF2203 PF09969.9 PIK38501.1 - 0.39 11.5 15.1 0.2 12.4 7.8 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) CENP-Q PF13094.6 PIK38501.1 - 0.43 10.8 6.5 0.67 10.1 6.5 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HrpB7 PF09486.10 PIK38501.1 - 0.6 10.5 10.1 3 8.2 0.7 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Seryl_tRNA_N PF02403.22 PIK38501.1 - 0.61 10.3 21.7 3.2 8.0 11.5 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Serine_rich PF08824.10 PIK38501.1 - 0.64 10.0 3.0 17 5.4 0.4 2.8 1 1 2 3 3 3 0 Serine rich protein interaction domain COG2 PF06148.11 PIK38501.1 - 0.68 10.0 12.3 5.7 7.0 1.2 3.2 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_13 PF13166.6 PIK38501.1 - 0.71 8.4 25.9 2.1 6.9 25.9 1.6 1 1 0 1 1 1 0 AAA domain MAD PF05557.13 PIK38501.1 - 0.87 7.9 16.4 1.2 7.5 16.4 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Sec34 PF04136.15 PIK38501.1 - 0.93 9.4 14.9 19 5.1 1.4 2.9 1 1 1 2 2 2 0 Sec34-like family ISG65-75 PF11727.8 PIK38501.1 - 1 8.6 25.6 1.3 8.2 13.0 2.3 1 1 1 2 2 2 0 Invariant surface glycoprotein DASH_Dad2 PF08654.10 PIK38501.1 - 1.1 9.8 19.0 1.1 9.7 5.8 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad2 Lebercilin PF15619.6 PIK38501.1 - 1.2 8.8 14.5 1.7 8.3 1.6 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Ndc1_Nup PF09531.10 PIK38501.1 - 1.3 7.6 4.0 1.7 7.2 4.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4407 PF14362.6 PIK38501.1 - 1.4 8.2 18.6 2.1 7.6 18.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG17 PF04108.12 PIK38501.1 - 1.5 7.8 17.9 1.4 7.9 10.7 2.0 1 1 1 2 2 2 0 Autophagy protein Apg17 LUC7 PF03194.15 PIK38501.1 - 1.6 8.3 23.1 0.55 9.9 11.7 2.4 1 1 2 3 3 3 0 LUC7 N_terminus RPW8 PF05659.11 PIK38501.1 - 2 8.1 17.7 6.1 6.5 1.0 3.2 1 1 2 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TPR_MLP1_2 PF07926.12 PIK38501.1 - 2.3 8.3 19.3 2.7 8.1 10.7 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 PIK38501.1 - 2.6 7.2 15.0 4.4 6.4 13.2 2.0 1 1 1 2 2 2 0 TMPIT-like protein PIEZO PF15917.5 PIK38501.1 - 2.7 7.4 14.2 9.8e+02 -1.0 14.1 2.8 1 1 0 1 1 1 0 Piezo UPF0176_N PF17773.1 PIK38501.1 - 2.7 8.4 4.5 31 5.0 4.6 2.4 1 1 0 1 1 1 0 UPF0176 acylphosphatase like domain KELK PF15796.5 PIK38501.1 - 3 8.4 12.9 11 6.6 0.7 2.7 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase CENP-F_leu_zip PF10473.9 PIK38501.1 - 3.3 7.7 22.6 2.1 8.4 10.0 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF334 PF03904.13 PIK38501.1 - 3.5 7.1 6.9 5.1 6.6 6.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF334) HMMR_N PF15905.5 PIK38501.1 - 4 6.8 23.4 13 5.1 23.4 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal SKA2 PF16740.5 PIK38501.1 - 4 7.3 9.2 78 3.1 8.2 3.1 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 V_ATPase_I PF01496.19 PIK38501.1 - 4.9 4.9 10.7 6.7 4.5 10.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BLOC1_2 PF10046.9 PIK38501.1 - 5.2 7.4 16.5 1.8e+03 -0.7 16.5 3.1 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Halo_GVPC PF05465.13 PIK38501.1 - 5.5 7.3 9.1 10 6.5 2.1 3.4 1 1 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat CREPT PF16566.5 PIK38501.1 - 6.3 7.0 9.3 8.2 6.6 7.2 2.0 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour FlgN PF05130.12 PIK38501.1 - 6.7 7.2 19.2 1.1 9.7 8.9 2.2 1 1 1 2 2 2 0 FlgN protein DUF211 PF02680.14 PIK38501.1 - 6.8 6.9 16.8 10 6.4 7.8 3.2 1 1 3 4 4 4 0 Uncharacterized ArCR, COG1888 PI3K_P85_iSH2 PF16454.5 PIK38501.1 - 7 6.2 11.4 30 4.2 11.4 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF812 PF05667.11 PIK38501.1 - 7.9 5.2 25.4 21 3.8 25.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) HemX PF04375.14 PIK38501.1 - 9.1 5.5 13.9 2.5 7.3 5.9 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Golgin_A5 PF09787.9 PIK38501.1 - 9.9 5.5 18.2 28 4.1 18.1 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 IBR PF01485.21 PIK38502.1 - 0.00076 19.7 12.4 0.0016 18.6 12.4 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain F-box-like PF12937.7 PIK38502.1 - 0.002 18.0 0.3 0.0039 17.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like Hemocyanin_M PF00372.19 PIK38502.1 - 0.0033 16.7 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, copper containing domain Transposase_24 PF03004.14 PIK38502.1 - 0.031 14.4 5.2 0.034 14.2 0.2 2.4 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) FYVE_2 PF02318.16 PIK38502.1 - 3.5 7.9 10.4 9.5 6.5 10.4 1.9 1 1 0 1 1 1 0 FYVE-type zinc finger SSF PF00474.17 PIK38503.1 - 4.8e-62 210.1 2.8 4.8e-62 210.1 2.8 1.8 3 0 0 3 3 3 1 Sodium:solute symporter family Serpin PF00079.20 PIK38504.1 - 3.8e-115 385.2 0.5 4.3e-115 385.0 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) COPIIcoated_ERV PF07970.12 PIK38505.1 - 3.5e-94 314.8 0.8 4.9e-94 314.3 0.8 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 PIK38505.1 - 9.7e-32 109.2 0.0 2.1e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) TMEM18 PF14770.6 PIK38506.1 - 3.2e-41 140.0 8.4 3.9e-41 139.8 8.4 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 Bac_export_2 PF01312.19 PIK38506.1 - 7.5 5.7 6.3 3.4 6.8 3.9 1.5 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family uDENN PF03456.18 PIK38507.1 - 4.6e-05 24.1 0.2 0.00013 22.6 0.2 1.9 1 0 0 1 1 1 1 uDENN domain DENN PF02141.21 PIK38507.1 - 0.015 15.2 1.3 0.02 14.9 0.2 1.8 2 0 0 2 2 2 0 DENN (AEX-3) domain PP2C PF00481.21 PIK38508.1 - 9.3e-77 258.1 0.0 1.2e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK38508.1 - 6.4e-08 32.5 0.0 1.2e-07 31.5 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C CARD_2 PF16739.5 PIK38508.1 - 0.065 13.2 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Caspase recruitment domain GH3 PF03321.13 PIK38509.1 - 4.1e-106 355.9 0.0 4.6e-106 355.8 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter GH3 PF03321.13 PIK38510.1 - 1.1e-19 70.7 0.0 1.5e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Fucokinase PF07959.12 PIK38511.1 - 1.6e-115 386.3 0.9 2e-115 386.0 0.9 1.1 1 0 0 1 1 1 1 L-fucokinase UbiA PF01040.18 PIK38512.1 - 2.6e-52 177.7 14.8 3.4e-52 177.3 14.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family SH3_9 PF14604.6 PIK38513.1 - 1.1e-47 159.7 0.4 2.5e-12 46.4 0.0 4.3 4 0 0 4 4 4 4 Variant SH3 domain SH3_1 PF00018.28 PIK38513.1 - 4e-46 154.4 1.3 7.6e-12 44.6 0.1 4.3 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.17 PIK38513.1 - 4.4e-37 125.6 3.1 1.6e-11 43.7 0.1 4.5 4 0 0 4 4 4 4 Variant SH3 domain zf-C3HC4_2 PF13923.6 PIK38513.1 - 4.1e-09 36.1 8.3 4.1e-09 36.1 8.3 2.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK38513.1 - 1.6e-08 34.3 8.9 4.4e-08 32.9 8.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK38513.1 - 1.9e-08 34.5 8.7 1.9e-08 34.5 8.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK38513.1 - 5.6e-08 32.5 6.7 5.6e-08 32.5 6.7 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK38513.1 - 7.4e-07 29.0 7.6 1.5e-06 28.1 7.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK38513.1 - 7.8e-06 25.8 6.0 7.8e-06 25.8 6.0 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 PIK38513.1 - 2.4e-05 24.0 5.9 2.4e-05 24.0 5.9 2.1 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 PIK38513.1 - 0.00022 21.3 7.8 0.00044 20.3 7.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK38513.1 - 0.00072 19.4 7.5 0.0018 18.1 7.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 PIK38513.1 - 0.0028 17.5 2.8 0.0056 16.5 2.8 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 PIK38513.1 - 0.0031 17.2 3.5 0.0031 17.2 3.5 2.7 2 1 1 3 3 3 1 RING-like zinc finger zf-P11 PF03854.14 PIK38513.1 - 0.15 11.8 6.1 0.32 10.7 6.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger DUF1272 PF06906.11 PIK38513.1 - 0.5 10.5 6.0 1.1 9.4 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.7 PIK38513.1 - 0.59 10.5 10.0 0.06 13.6 4.5 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 PIK38513.1 - 1.2 9.2 4.6 3.2 7.8 4.6 1.7 1 0 0 1 1 1 0 zinc-ribbons zf-MIZ PF02891.20 PIK38513.1 - 1.3 8.9 6.3 2.3 8.1 6.3 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Nse PF11789.8 PIK38513.1 - 1.5 8.7 7.3 28 4.6 4.0 3.2 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Ion_trans PF00520.31 PIK38514.1 - 2.2e-30 105.7 14.9 2.9e-30 105.3 14.9 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK38514.1 - 8.6e-10 37.9 12.5 5.1e-09 35.3 12.4 2.0 1 1 0 1 1 1 1 Polycystin cation channel DUF1218 PF06749.12 PIK38514.1 - 0.21 12.1 2.9 0.24 11.9 0.2 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1218) Bac_export_2 PF01312.19 PIK38514.1 - 2.2 7.4 3.9 4.4 6.4 0.6 2.2 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family MBT PF02820.18 PIK38516.1 - 4.7e-77 254.3 4.2 3.4e-22 78.6 0.0 4.4 4 0 0 4 4 4 4 mbt repeat NARP1 PF12569.8 PIK38516.1 - 0.52 9.1 14.0 0.91 8.4 14.0 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EIIBC-GUT_N PF03612.14 PIK38516.1 - 1.1 8.9 4.2 2.8 7.6 4.2 1.7 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3987 PF13148.6 PIK38516.1 - 4.9 6.1 6.8 9.7 5.1 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Eapp_C PF10238.9 PIK38516.1 - 6.5 6.8 8.3 22 5.1 8.3 1.9 1 0 0 1 1 1 0 E2F-associated phosphoprotein SAM_PNT PF02198.16 PIK38517.1 - 6.5e-05 22.8 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_1 PF00536.30 PIK38517.1 - 0.00021 21.7 0.0 0.00037 20.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK38517.1 - 0.00024 21.1 0.0 0.00044 20.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 PIK38517.1 - 0.093 12.6 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2294 PF10057.9 PIK38517.1 - 0.2 11.8 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) PAT1 PF09770.9 PIK38517.1 - 0.25 9.5 10.3 0.28 9.4 10.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GTP-bdg_M PF16360.5 PIK38518.1 - 1e-18 67.7 5.2 2.2e-18 66.6 5.2 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 PIK38518.1 - 4.1e-16 59.1 0.1 1.2e-14 54.3 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.6 PIK38518.1 - 1.2e-13 51.5 0.0 2.5e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal cobW PF02492.19 PIK38518.1 - 0.00028 20.5 0.7 0.2 11.3 0.0 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 PIK38518.1 - 0.0076 16.3 0.1 0.58 10.2 0.0 2.5 1 1 1 2 2 2 1 Dynamin family FeoB_N PF02421.18 PIK38518.1 - 0.0088 15.6 0.2 0.026 14.0 0.2 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK38518.1 - 0.063 13.2 0.1 1 9.3 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 PIK38519.1 - 1.7e-39 135.4 0.0 4.3e-39 134.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK38519.1 - 3.8e-22 78.7 0.0 1.6e-20 73.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK38519.1 - 1e-06 28.9 2.9 5.1e-06 26.6 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 PIK38519.1 - 0.00028 20.8 0.3 0.025 14.4 0.0 2.5 2 0 0 2 2 2 1 Helicase Helicase_C_2 PF13307.6 PIK38519.1 - 0.86 9.8 4.0 6.3 6.9 0.0 2.9 3 0 0 3 3 3 0 Helicase C-terminal domain WD40 PF00400.32 PIK38520.1 - 1.5e-27 95.2 9.4 0.00037 21.2 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38520.1 - 0.0019 18.4 0.2 3.9 7.8 0.0 3.8 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK38520.1 - 0.0027 17.6 0.0 0.41 10.5 0.0 3.0 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK38520.1 - 0.0033 16.1 9.4 2.5 6.6 0.1 4.2 2 2 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK38520.1 - 0.057 12.7 0.0 11 5.2 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain Gemin7 PF11095.8 PIK38522.1 - 0.057 13.3 0.1 0.57 10.1 0.0 2.4 2 0 0 2 2 2 0 Gem-associated protein 7 (Gemin7) Glyco_transf_18 PF15024.6 PIK38522.1 - 0.93 8.0 6.5 0.22 10.1 2.9 1.7 1 1 1 2 2 2 0 Glycosyltransferase family 18 Tmemb_cc2 PF10267.9 PIK38522.1 - 3.4 6.7 31.4 0.011 14.9 12.9 2.3 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Kinesin PF00225.23 PIK38523.1 - 4.2e-50 170.5 5.9 2.5e-49 168.0 1.9 3.2 2 1 0 2 2 2 1 Kinesin motor domain CENP-H PF05837.12 PIK38523.1 - 0.00017 21.9 4.6 0.00045 20.6 4.6 1.7 1 0 0 1 1 1 1 Centromere protein H (CENP-H) Csm1_N PF18504.1 PIK38523.1 - 0.0015 18.8 0.9 0.0015 18.8 0.9 2.3 1 1 1 2 2 2 1 Csm1 N-terminal domain DUF4962 PF16332.5 PIK38523.1 - 0.018 13.6 0.8 0.025 13.1 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) SIR2_2 PF13289.6 PIK38523.1 - 0.022 14.9 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 SIR2-like domain ZapB PF06005.12 PIK38523.1 - 0.027 14.9 5.3 0.25 11.8 5.3 2.2 1 1 0 1 1 1 0 Cell division protein ZapB Cnn_1N PF07989.11 PIK38523.1 - 0.052 13.7 5.2 0.2 11.8 2.8 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 JIP_LZII PF16471.5 PIK38523.1 - 0.14 12.4 4.3 0.8 9.9 0.6 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II GIT1_C PF12205.8 PIK38523.1 - 0.2 11.8 3.0 0.37 10.9 2.4 1.7 1 1 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Fib_alpha PF08702.10 PIK38523.1 - 0.36 11.0 5.7 0.7 10.1 5.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 PIK38523.1 - 0.44 8.4 5.9 0.55 8.1 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 PIK38523.1 - 2.2 8.1 8.7 8.9 6.2 1.2 2.4 1 1 1 2 2 2 0 Septum formation initiator YabA PF06156.13 PIK38523.1 - 3.7 8.2 6.3 8.2 7.1 4.4 2.6 2 1 0 2 2 2 0 Initiation control protein YabA Kinesin PF00225.23 PIK38524.1 - 2e-23 82.9 0.2 2.4e-23 82.6 0.2 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK38524.1 - 3e-18 66.2 0.1 3.4e-18 66.0 0.1 1.1 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 PIK38524.1 - 0.024 13.8 0.1 0.029 13.5 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase Myb_DNA-binding PF00249.31 PIK38526.1 - 2.1e-49 165.5 13.4 1e-16 60.8 0.8 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK38526.1 - 3.1e-38 129.8 10.9 2.2e-17 63.0 0.3 4.0 2 1 2 4 4 4 3 Myb-like DNA-binding domain Cmyb_C PF09316.10 PIK38526.1 - 1.8e-24 86.3 0.4 5e-24 84.8 0.4 1.8 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-bind_7 PF15963.5 PIK38526.1 - 9.4e-08 31.9 3.3 0.00084 19.2 0.1 3.1 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 PIK38526.1 - 1.8e-05 24.8 0.3 2.1 8.4 0.0 4.0 1 1 2 4 4 4 2 SLIDE Rap1_C PF11626.8 PIK38526.1 - 0.66 10.1 5.9 8.5 6.5 0.3 3.4 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain TB2_DP1_HVA22 PF03134.19 PIK38527.1 - 0.0013 18.7 0.8 0.0021 18.0 0.8 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family NDUF_B6 PF09782.9 PIK38527.1 - 0.022 14.9 0.0 0.027 14.6 0.0 1.1 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit PspB PF06667.12 PIK38527.1 - 4 7.6 5.3 1.5 8.9 0.2 2.1 2 0 0 2 2 2 0 Phage shock protein B F-box-like PF12937.7 PIK38529.1 - 4.3e-12 45.7 1.7 1.1e-11 44.5 1.7 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK38529.1 - 7.5e-08 32.1 1.1 1.9e-07 30.8 1.1 1.8 1 1 0 1 1 1 1 F-box domain F-box_4 PF15966.5 PIK38529.1 - 0.017 15.0 0.0 0.041 13.8 0.0 1.7 1 0 0 1 1 1 0 F-box rve PF00665.26 PIK38531.1 - 4.3e-22 78.5 0.0 5.3e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK38531.1 - 0.0097 15.7 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK38532.1 - 3e-31 108.7 0.0 4.6e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK38532.1 - 2.9e-14 52.9 0.0 3.3e-13 49.5 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK38532.1 - 2.4e-09 37.6 0.0 5.6e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK38532.1 - 1.7e-08 35.0 0.0 5.4e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease RT_RNaseH PF17917.1 PIK38532.1 - 0.03 14.6 0.0 2.6 8.4 0.0 2.6 1 1 1 2 2 2 0 RNase H-like domain found in reverse transcriptase RVP PF00077.20 PIK38532.1 - 0.038 14.3 0.0 0.11 12.8 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease nos_propeller_2 PF18793.1 PIK38533.1 - 0.044 14.1 0.0 0.08 13.3 0.0 1.4 1 0 0 1 1 1 0 Nitrous oxide reductase propeller repeat 2 Collagen PF01391.18 PIK38534.1 - 0.39 10.5 14.5 0.033 13.9 8.5 2.3 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) SprT-like PF10263.9 PIK38535.1 - 4.9e-28 97.3 0.0 8.6e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 SprT-like family zf-CpG_bind_C PF12269.8 PIK38536.1 - 0.012 15.4 1.6 0.037 13.8 0.0 2.3 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain UBZ_FAAP20 PF15750.5 PIK38536.1 - 0.21 11.5 0.3 0.46 10.5 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger Zn-ribbon_8 PF09723.10 PIK38536.1 - 1.1 9.5 3.9 2.8 8.1 0.9 2.9 3 0 0 3 3 3 0 Zinc ribbon domain Mitofilin PF09731.9 PIK38536.1 - 1.9 7.3 11.1 2.5 6.8 11.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Metallophos PF00149.28 PIK38537.1 - 0.08 13.4 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK38538.1 - 2.8e-16 59.7 0.7 4.6e-16 59.0 0.7 1.3 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 PIK38538.1 - 8.1e-07 29.7 0.0 9e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ResIII PF04851.15 PIK38539.1 - 1.3e-07 31.7 0.1 2.3e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK38539.1 - 7.6e-07 29.1 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Tmemb_18A PF09771.9 PIK38539.1 - 0.82 10.1 3.5 25 5.3 0.1 2.3 1 1 1 2 2 2 0 Transmembrane protein 188 Dicer_dimer PF03368.14 PIK38540.1 - 4.5e-29 100.4 0.0 1.3e-28 99.0 0.0 1.9 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 PIK38540.1 - 3.4e-12 46.7 0.0 6.3e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribonuclease_3 PF00636.26 PIK38541.1 - 3.4e-23 82.3 0.0 5.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 PIK38541.1 - 3.2e-06 27.3 0.0 5.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 PIK38542.1 - 3.4e-32 111.2 0.0 3e-23 82.4 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 PIK38542.1 - 1.6e-13 50.9 0.0 7.6e-10 39.0 0.0 3.3 2 1 0 2 2 2 2 Ribonuclease-III-like RGS-like PF09128.11 PIK38543.1 - 2.3e-42 144.8 0.1 3.1e-42 144.4 0.1 1.1 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain C1_1 PF00130.22 PIK38543.1 - 1.1e-11 44.5 4.0 1.7e-11 43.8 4.0 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RGS PF00615.19 PIK38543.1 - 2.9e-09 37.2 0.3 6.3e-09 36.1 0.3 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Thioredoxin_14 PF18402.1 PIK38543.1 - 0.083 12.8 0.3 0.13 12.1 0.3 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain C1_2 PF03107.16 PIK38543.1 - 0.2 12.0 1.5 0.37 11.1 1.5 1.4 1 0 0 1 1 1 0 C1 domain PH_16 PF17838.1 PIK38544.1 - 2.3e-30 105.0 0.2 1.1e-29 102.8 0.1 2.2 2 1 0 2 2 2 1 PH domain RhoGEF PF00621.20 PIK38544.1 - 2.4e-18 67.0 1.0 1e-15 58.4 0.0 2.4 1 1 1 2 2 2 2 RhoGEF domain PH PF00169.29 PIK38544.1 - 0.00028 21.4 0.2 0.0015 19.0 0.0 2.4 3 0 0 3 3 3 1 PH domain Phosphorylase PF00343.20 PIK38546.1 - 0.0011 17.3 0.3 0.23 9.7 0.1 2.0 1 1 1 2 2 2 2 Carbohydrate phosphorylase HV_small_capsid PF17086.5 PIK38546.1 - 8.9 6.7 19.7 8.6 6.7 0.4 4.9 1 1 4 5 5 5 0 Small capsid protein of Herpesviridae 7tm_1 PF00001.21 PIK38547.1 - 2.1e-19 69.9 1.8 2.6e-19 69.6 1.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK38547.1 - 2.7e-05 23.7 9.2 3.6e-05 23.3 9.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx AGTRAP PF06396.11 PIK38547.1 - 0.019 14.7 2.9 0.025 14.4 1.4 1.9 2 0 0 2 2 2 0 Angiotensin II, type I receptor-associated protein (AGTRAP) FtsX PF02687.21 PIK38547.1 - 0.32 11.5 11.6 0.13 12.7 1.5 2.3 2 0 0 2 2 2 0 FtsX-like permease family Gal_Lectin PF02140.18 PIK38548.1 - 4.5e-28 97.5 17.1 5.7e-17 61.9 3.0 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain Methyltransf_FA PF12248.8 PIK38548.1 - 6.5e-21 74.6 0.0 9.4e-07 29.1 0.0 4.5 4 0 0 4 4 4 4 Farnesoic acid 0-methyl transferase LRR_8 PF13855.6 PIK38549.1 - 2.8e-14 52.6 17.3 2.8e-09 36.6 5.0 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK38549.1 - 2.7e-07 30.8 3.7 0.0018 18.6 2.0 2.8 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK38549.1 - 1.3e-05 25.0 3.2 0.022 15.3 0.7 4.0 2 2 0 2 2 2 2 Leucine Rich Repeat UCH PF00443.29 PIK38550.1 - 5.5e-28 98.2 0.0 6.9e-28 97.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 PIK38550.1 - 7.2e-24 83.3 3.7 5.9e-13 48.4 0.1 2.9 3 0 0 3 3 3 2 UBA/TS-N domain UCH_1 PF13423.6 PIK38550.1 - 2.8e-10 40.3 0.0 2.7e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_5 PF16577.5 PIK38550.1 - 0.0012 18.9 0.0 0.26 11.5 0.0 2.4 2 0 0 2 2 2 1 UBA domain UBA_4 PF14555.6 PIK38550.1 - 0.0032 17.2 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 PIK38550.1 - 0.02 14.6 0.2 0.06 13.1 0.0 2.0 2 0 0 2 2 2 0 CUE domain UBA_3 PF09288.10 PIK38550.1 - 0.053 13.3 0.0 4.2 7.3 0.0 2.6 2 1 0 2 2 2 0 Fungal ubiquitin-associated domain CRAL_TRIO_N PF03765.15 PIK38550.1 - 0.058 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain zf-UBP_var PF17807.1 PIK38551.1 - 8.3e-27 92.7 0.9 5.4e-25 86.9 0.7 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 PIK38551.1 - 4.5e-18 65.3 0.0 3.9e-15 55.9 0.0 2.4 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 PIK38551.1 - 1.7e-10 40.8 0.0 3.1e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2180 PF09947.9 PIK38551.1 - 0.029 14.3 0.1 0.84 9.6 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) UCH_1 PF13423.6 PIK38551.1 - 0.032 13.8 0.1 0.054 13.1 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Menin PF05053.13 PIK38552.1 - 0.4 9.0 4.7 0.46 8.8 4.7 1.1 1 0 0 1 1 1 0 Menin RVT_1 PF00078.27 PIK38553.1 - 2.3e-19 69.8 0.0 6.3e-19 68.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK38553.1 - 0.026 14.4 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Med18 protein DUF3201 PF11447.8 PIK38554.1 - 0.03 13.9 0.9 0.042 13.4 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) Thioredoxin PF00085.20 PIK38555.1 - 6.2e-21 74.3 0.0 5.7e-20 71.2 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 PIK38555.1 - 5.4e-05 23.3 0.1 0.00017 21.7 0.0 1.9 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 PIK38555.1 - 9.4e-05 22.7 0.0 3.1 8.2 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK38555.1 - 0.00023 21.6 0.1 0.0043 17.5 0.0 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 PIK38555.1 - 0.0022 17.8 0.0 0.0052 16.6 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin Prefoldin_2 PF01920.20 PIK38556.1 - 1.2e-18 67.0 10.0 6e-10 39.0 3.2 2.1 2 0 0 2 2 2 2 Prefoldin subunit UPF0242 PF06785.11 PIK38556.1 - 0.00018 21.6 1.3 0.00023 21.3 1.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Prefoldin PF02996.17 PIK38556.1 - 0.00047 20.1 9.4 0.0048 16.8 9.4 2.0 1 1 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.11 PIK38556.1 - 0.018 15.3 7.9 0.054 13.7 1.6 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Spectrin PF00435.21 PIK38556.1 - 0.047 14.2 4.4 0.08 13.4 1.0 2.1 2 0 0 2 2 2 0 Spectrin repeat GLE1 PF07817.13 PIK38556.1 - 0.076 12.2 0.0 0.17 11.1 0.0 1.5 1 1 0 1 1 1 0 GLE1-like protein DUF1664 PF07889.12 PIK38556.1 - 0.095 12.7 5.2 3.3 7.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FliD_N PF02465.18 PIK38556.1 - 0.099 13.4 1.0 0.099 13.4 1.0 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF5320 PF17253.2 PIK38556.1 - 0.16 13.1 0.5 2.1 9.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DivIC PF04977.15 PIK38556.1 - 0.27 11.0 11.7 0.67 9.8 1.1 2.5 2 1 0 2 2 2 0 Septum formation initiator NPV_P10 PF05531.12 PIK38556.1 - 0.35 11.3 8.5 0.15 12.6 2.1 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.6 PIK38556.1 - 0.49 10.9 5.3 0.71 10.4 1.4 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Snapin_Pallidin PF14712.6 PIK38556.1 - 0.51 10.8 8.0 0.11 12.9 1.1 2.1 2 0 0 2 2 2 0 Snapin/Pallidin DUF2508 PF10704.9 PIK38556.1 - 0.93 9.7 7.8 0.46 10.7 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) DUF3552 PF12072.8 PIK38556.1 - 3.1 7.2 11.6 8.3 5.8 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Spc7 PF08317.11 PIK38556.1 - 5.2 5.9 11.6 6.5 5.5 0.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Spc24 PF08286.11 PIK38557.1 - 0.089 13.0 4.5 0.42 10.9 4.5 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Spc7 PF08317.11 PIK38557.1 - 0.43 9.4 7.4 0.78 8.6 7.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 PIK38557.1 - 3.6 7.4 8.0 6 6.7 3.7 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF1043 PF06295.12 PIK38557.1 - 4.9 7.2 5.3 3.6 7.6 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) HIP1_clath_bdg PF16515.5 PIK38557.1 - 7.7 7.2 14.3 3.8 8.2 4.6 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 PIK38557.1 - 9.6 6.9 8.3 6.7 7.4 3.2 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DUF5567 PF17722.1 PIK38559.1 - 3.1e-06 27.3 3.6 5.9e-06 26.3 3.6 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5567) NAM-associated PF14303.6 PIK38559.1 - 0.065 14.0 1.5 0.17 12.6 1.5 1.6 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Ank_2 PF12796.7 PIK38560.1 - 1.5e-15 57.6 0.1 9.9e-09 35.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK38560.1 - 7.3e-15 54.8 1.4 5e-08 33.1 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK38560.1 - 2.6e-12 46.6 0.9 0.00021 21.6 0.4 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 PIK38560.1 - 1.4e-11 44.7 0.2 3.6e-05 24.2 0.0 4.6 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK38560.1 - 1.6e-09 37.2 0.5 2.5e-06 27.4 0.1 4.5 4 0 0 4 4 4 1 Ankyrin repeat rhaM PF05336.13 PIK38560.1 - 0.023 14.8 1.9 0.056 13.5 1.3 1.9 2 0 0 2 2 2 0 L-rhamnose mutarotase Peptidase_M16 PF00675.20 PIK38560.1 - 0.16 11.9 0.2 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) NuA4 PF09340.10 PIK38560.1 - 0.24 11.3 1.0 0.78 9.7 1.0 1.9 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Ank_4 PF13637.6 PIK38561.1 - 9.6e-14 51.6 0.0 1.5e-07 31.9 0.0 3.5 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK38561.1 - 1.1e-09 38.4 0.4 4.1e-07 30.2 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK38561.1 - 3.3e-09 37.2 0.0 5.2e-07 30.2 0.0 3.1 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK38561.1 - 1.1e-08 34.6 0.0 0.00082 19.7 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 PIK38561.1 - 1.1e-07 32.0 0.6 2.8e-05 24.3 0.0 3.6 3 1 0 3 3 3 1 Ankyrin repeat Cystatin PF00031.21 PIK38562.1 - 0.016 15.5 0.1 0.039 14.2 0.1 1.7 1 0 0 1 1 1 0 Cystatin domain DUF2666 PF10869.8 PIK38562.1 - 0.051 13.8 0.5 0.095 12.9 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) BID PF06393.11 PIK38563.1 - 0.0052 16.3 0.7 0.011 15.4 0.7 1.5 1 1 0 1 1 1 1 BH3 interacting domain (BID) DUF1771 PF08590.10 PIK38563.1 - 0.026 14.9 0.5 0.056 13.8 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) Bcl-2 PF00452.19 PIK38563.1 - 0.15 12.7 0.6 0.3 11.8 0.1 1.8 2 1 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Bcl-2 PF00452.19 PIK38564.1 - 0.0018 18.9 0.1 0.0038 17.9 0.1 1.5 1 1 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BID PF06393.11 PIK38564.1 - 0.034 13.7 0.1 0.056 13.0 0.1 1.3 1 0 0 1 1 1 0 BH3 interacting domain (BID) DUF29 PF01724.16 PIK38564.1 - 0.063 13.5 0.9 0.093 13.0 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF29 fn3 PF00041.21 PIK38565.1 - 7.8e-08 32.6 0.4 1.6e-05 25.2 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain CARD_2 PF16739.5 PIK38566.1 - 4e-13 49.2 0.2 8.6e-13 48.1 0.2 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Sugar_tr PF00083.24 PIK38567.1 - 2.2e-29 102.7 11.3 2.9e-29 102.2 11.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK38567.1 - 1.2e-25 90.2 46.6 7.4e-23 81.0 24.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5526 PF17664.1 PIK38567.1 - 0.051 13.1 0.3 0.095 12.3 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5526) LsmAD PF06741.13 PIK38568.1 - 5.4e-06 26.9 0.1 1.4e-05 25.5 0.1 1.7 1 0 0 1 1 1 1 LsmAD domain Sec16_C PF12931.7 PIK38570.1 - 4e-39 135.1 0.3 6.6e-39 134.4 0.3 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 PIK38570.1 - 1.3e-08 35.4 0.1 5.5e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region DUF5588 PF17826.1 PIK38570.1 - 0.029 13.3 0.1 0.054 12.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5588) Acetyltransf_2 PF00797.17 PIK38571.1 - 2.7e-06 27.4 0.0 3.1e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Transglut_core PF01841.19 PIK38571.1 - 0.029 14.8 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily Acetyltransf_2 PF00797.17 PIK38573.1 - 1.4e-05 25.0 0.0 2.2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 N-acetyltransferase Pkinase PF00069.25 PIK38574.1 - 2.7e-16 59.7 0.0 3.7e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38574.1 - 3.8e-11 42.8 0.0 5.1e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SMP_LBD PF17047.5 PIK38574.1 - 0.078 12.4 0.0 0.36 10.3 0.0 1.8 1 1 0 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain Pkinase PF00069.25 PIK38576.1 - 6.7e-16 58.4 0.0 9.8e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38576.1 - 5.1e-10 39.1 0.0 7.3e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK38576.1 - 0.044 13.1 0.0 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1280 PF06918.14 PIK38579.1 - 0.0033 17.1 0.0 0.0055 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1280) 7tm_1 PF00001.21 PIK38580.1 - 1.1e-36 126.5 3.0 1.5e-36 126.1 3.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK38580.1 - 2.4e-07 30.6 1.3 2.4e-07 30.6 1.3 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK38580.1 - 1.3e-06 28.0 3.6 0.01 15.2 0.1 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 PIK38580.1 - 0.001 18.2 0.3 0.0038 16.4 0.0 1.8 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) SNARE_assoc PF09335.11 PIK38580.1 - 0.013 16.0 0.1 0.033 14.7 0.1 1.6 1 0 0 1 1 1 0 SNARE associated Golgi protein Piezo_RRas_bdg PF12166.8 PIK38580.1 - 0.053 12.8 0.1 0.072 12.4 0.1 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain zf-LITAF-like PF10601.9 PIK38580.1 - 0.21 11.9 0.1 0.21 11.9 0.1 2.4 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain RVT_1 PF00078.27 PIK38581.1 - 6.6e-42 143.5 1.7 7.8e-42 143.3 1.7 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L9_C PF03948.14 PIK38581.1 - 0.05 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L9, C-terminal domain DUF2555 PF10742.9 PIK38581.1 - 0.15 11.9 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) ig PF00047.25 PIK38582.1 - 1.2e-10 41.4 1.4 0.0071 16.5 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK38582.1 - 5.7e-10 39.3 0.8 0.0018 18.4 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK38582.1 - 8.1e-08 32.8 3.0 0.03 14.9 0.1 5.0 4 0 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK38582.1 - 1.4e-05 25.1 0.3 0.14 12.3 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK38582.1 - 0.0001 22.6 5.6 0.27 11.6 0.2 4.9 3 2 2 5 5 5 2 Immunoglobulin domain zf-CCHC PF00098.23 PIK38583.1 - 1.6e-07 31.0 15.8 0.00046 20.1 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK38583.1 - 0.0017 18.3 12.7 0.18 11.8 1.3 3.5 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK38583.1 - 0.01 15.6 13.3 0.07 13.0 3.8 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38583.1 - 0.012 15.4 11.1 3.5 7.4 0.4 3.5 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38583.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK38583.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger Peptidase_A17 PF05380.13 PIK38584.1 - 1.8e-33 115.8 0.0 3.3e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase Chlamy_scaf PF09675.10 PIK38584.1 - 0.001 19.4 0.1 0.0024 18.2 0.1 1.6 1 0 0 1 1 1 1 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) rve PF00665.26 PIK38585.1 - 9.6e-09 35.5 0.0 1.5e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK38585.1 - 0.0058 16.4 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.6 PIK38585.1 - 0.04 13.7 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain BEN PF10523.9 PIK38586.1 - 3.1e-05 24.1 0.0 0.00019 21.6 0.0 2.1 2 0 0 2 2 2 1 BEN domain OrfB_Zn_ribbon PF07282.11 PIK38586.1 - 0.018 15.0 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF4407 PF14362.6 PIK38586.1 - 0.46 9.8 11.0 0.68 9.2 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.27 PIK38587.1 - 3.7e-05 23.3 0.0 0.00021 20.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4806 PF16064.5 PIK38588.1 - 8.8e-13 48.4 0.2 1.9e-12 47.3 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4806) Macoilin PF09726.9 PIK38588.1 - 0.0034 16.0 1.1 0.004 15.8 1.1 1.2 1 0 0 1 1 1 1 Macoilin family zf-CCHC PF00098.23 PIK38589.1 - 3.2e-06 27.0 22.7 0.00027 20.9 0.2 4.3 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK38589.1 - 0.00023 21.1 12.9 0.1 12.6 0.2 3.6 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK38589.1 - 0.0016 18.2 11.7 0.22 11.4 6.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38589.1 - 0.003 17.3 11.1 2.1 8.2 0.3 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38589.1 - 0.0093 15.8 0.2 0.0093 15.8 0.2 3.8 4 0 0 4 4 4 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK38589.1 - 0.0094 15.7 0.8 0.0094 15.7 0.8 2.8 1 1 1 2 2 2 1 C2H2 zinc-finger VapB_antitoxin PF09957.9 PIK38592.1 - 0.059 13.3 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB THAP PF05485.12 PIK38593.1 - 1.1e-16 61.5 0.7 1.6e-16 61.0 0.7 1.2 1 0 0 1 1 1 1 THAP domain DNA_ligase_ZBD PF03119.16 PIK38594.1 - 0.073 13.1 0.1 0.18 11.9 0.1 1.7 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain UCH PF00443.29 PIK38597.1 - 4e-08 33.1 1.1 6e-08 32.5 1.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DGCR6 PF07324.11 PIK38597.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein VapB_antitoxin PF09957.9 PIK38598.1 - 0.055 13.4 0.2 0.22 11.5 0.0 2.1 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB SAM_1 PF00536.30 PIK38598.1 - 0.13 12.8 0.1 0.43 11.1 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) FXMRP1_C_core PF12235.8 PIK38601.1 - 0.072 13.7 6.5 0.24 12.0 5.0 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal PRR20 PF15708.5 PIK38601.1 - 7.7 6.3 8.0 13 5.7 8.0 1.3 1 0 0 1 1 1 0 Proline-rich protein family 20 Pkinase_Tyr PF07714.17 PIK38602.1 - 7.2e-28 97.6 0.0 9.2e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK38602.1 - 8e-16 58.2 0.0 1.1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain BRICHOS PF04089.14 PIK38603.1 - 4e-06 27.0 0.0 9.8e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 BRICHOS domain Bac_rhamnosid_C PF17390.2 PIK38603.1 - 0.21 11.4 0.0 0.4 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase C-terminal domain BTB PF00651.31 PIK38604.1 - 5.4e-16 58.8 0.0 8.1e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 PIK38605.1 - 1.5e-32 110.9 7.3 1.7e-11 43.5 0.1 5.1 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 PIK38605.1 - 7.5e-22 76.8 7.7 7.6e-06 26.0 0.0 4.8 3 1 1 4 4 4 4 Kelch motif Kelch_2 PF07646.15 PIK38605.1 - 4.4e-14 51.8 3.5 3.8e-06 26.7 0.0 4.2 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 PIK38605.1 - 4.7e-09 36.1 7.7 0.0041 17.1 0.0 3.9 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK38605.1 - 6.9e-09 35.5 5.0 0.048 13.7 0.0 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 PIK38605.1 - 1.1e-08 35.2 2.5 1.1 9.6 0.0 4.4 4 1 0 4 4 4 4 Galactose oxidase, central domain PQQ_3 PF13570.6 PIK38605.1 - 0.044 14.3 0.4 24 5.6 0.1 3.6 4 0 0 4 4 4 0 PQQ-like domain PseudoU_synth_1 PF01416.20 PIK38606.1 - 5.1e-29 100.9 0.0 1.2e-21 77.2 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase CLTH PF10607.9 PIK38607.1 - 1e-34 119.6 1.8 1.3e-34 119.2 1.8 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 PIK38607.1 - 6.6e-10 38.6 0.6 2.3e-09 36.9 0.2 2.0 2 0 0 2 2 2 1 LisH TINF2_N PF14973.6 PIK38607.1 - 7e-05 23.2 1.6 0.00023 21.6 0.1 2.3 2 1 1 3 3 3 1 TERF1-interacting nuclear factor 2 N-terminus WRNPLPNID PF15017.6 PIK38607.1 - 0.68 10.8 4.5 3.8 8.4 0.3 3.0 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box RVT_1 PF00078.27 PIK38608.1 - 8e-35 120.4 0.1 1.6e-34 119.4 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK38608.1 - 3.2e-32 110.5 0.0 6.4e-32 109.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38608.1 - 3.3e-29 101.3 0.0 5.5e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CS PF04969.16 PIK38609.1 - 2.6e-15 57.2 0.0 1.1e-14 55.2 0.0 2.1 2 0 0 2 2 2 1 CS domain MRPL52 PF18699.1 PIK38610.1 - 1.3e-09 38.1 2.1 1.3e-09 38.1 2.1 1.7 2 0 0 2 2 2 1 Mitoribosomal protein mL52 Sec34 PF04136.15 PIK38611.1 - 0.029 14.3 3.3 0.12 12.2 1.0 2.1 2 0 0 2 2 2 0 Sec34-like family Halo_GVPC PF05465.13 PIK38611.1 - 0.049 13.9 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat Ctf8 PF09696.10 PIK38611.1 - 0.11 12.9 0.1 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Ctf8 BEX PF04538.12 PIK38611.1 - 0.16 12.5 4.0 1.6 9.3 0.8 2.2 2 0 0 2 2 2 0 Brain expressed X-linked like family Ig_3 PF13927.6 PIK38612.1 - 1.7e-06 28.5 1.2 0.0047 17.5 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK38612.1 - 4.4e-05 23.5 0.1 0.00056 19.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK38612.1 - 0.00017 21.7 0.3 0.00051 20.2 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK38612.1 - 0.0027 17.8 3.3 0.0041 17.3 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK38612.1 - 0.007 16.4 1.9 0.74 9.9 0.4 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK38612.1 - 0.069 12.7 1.0 14 5.3 0.1 2.9 3 0 0 3 3 3 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK38613.1 - 1.6e-30 106.3 0.0 2.1e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK38613.1 - 1.2e-17 64.2 0.0 1.7e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RVT_1 PF00078.27 PIK38614.1 - 1.1e-33 116.7 0.1 1.5e-30 106.4 0.1 2.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Y_phosphatase PF00102.27 PIK38614.1 - 1.4e-30 106.6 0.2 2.3e-30 105.9 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK38614.1 - 0.0017 18.2 0.0 0.0056 16.5 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK38614.1 - 0.033 14.3 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK38614.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family RVT_1 PF00078.27 PIK38617.1 - 8.5e-25 87.6 0.0 9.6e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4218 PF13960.6 PIK38618.1 - 0.044 13.4 0.3 0.12 12.0 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Cut8 PF08559.10 PIK38619.1 - 0.019 14.6 0.4 0.028 14.0 0.4 1.2 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein RVT_1 PF00078.27 PIK38620.1 - 6.1e-16 58.6 0.0 7.6e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK38621.1 - 1.2e-31 110.0 0.0 1.4e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK38622.1 - 4.9e-24 84.8 0.0 1e-23 83.8 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38622.1 - 7.3e-19 67.6 0.9 1.4e-18 66.7 0.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK38622.1 - 0.00027 21.1 0.4 0.0005 20.2 0.4 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK38622.1 - 0.0024 17.6 0.0 0.0058 16.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF5332 PF17266.2 PIK38622.1 - 0.068 12.9 0.1 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5332) RT_RNaseH_2 PF17919.1 PIK38623.1 - 7e-12 45.3 0.0 1.2e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38623.1 - 4.2e-11 42.8 0.0 6.3e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CDH1_2_SANT_HL1 PF18375.1 PIK38623.1 - 0.058 14.1 0.0 0.2 12.3 0.0 1.8 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Mt_ATP_synt PF15704.5 PIK38623.1 - 0.073 13.0 0.0 0.096 12.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit PNMA PF14893.6 PIK38624.1 - 0.0026 17.2 0.2 0.0035 16.8 0.2 1.3 1 0 0 1 1 1 1 PNMA RVT_1 PF00078.27 PIK38626.1 - 1e-05 25.2 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK38628.1 - 1.8e-09 37.5 0.0 2.1e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38628.1 - 0.071 13.0 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK38629.1 - 7.8e-16 58.3 0.0 1.2e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK38629.1 - 0.006 17.3 0.1 0.016 15.9 0.1 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK38630.1 - 1e-33 116.8 0.0 1.3e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK38631.1 - 3.1e-10 39.9 0.1 0.00053 19.6 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK38633.1 - 5.2e-18 65.4 0.0 6.8e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK38634.1 - 1.6e-05 24.7 15.2 0.0023 18.0 3.3 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38634.1 - 2.8e-05 23.7 14.0 0.19 11.5 0.4 3.6 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38634.1 - 0.002 17.9 0.2 0.002 17.9 0.2 3.0 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK38634.1 - 0.97 9.7 12.1 0.5 10.6 6.8 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain WD40 PF00400.32 PIK38635.1 - 9.6e-12 45.2 13.2 0.0034 18.2 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40 PF00400.32 PIK38636.1 - 1.6e-09 38.2 0.1 6.1e-05 23.7 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat EF-hand_7 PF13499.6 PIK38636.1 - 8.3e-09 35.8 1.3 2e-08 34.5 1.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK38636.1 - 7.1e-08 32.2 1.6 1.5e-07 31.1 1.6 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK38636.1 - 1.3e-05 24.7 0.3 0.22 11.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK38636.1 - 0.00022 20.6 0.4 0.018 14.5 0.1 2.7 2 0 0 2 2 2 1 EF hand CrgA PF06781.12 PIK38637.1 - 0.00014 21.8 0.1 0.00028 20.9 0.1 1.6 1 0 0 1 1 1 1 Cell division protein CrgA zf-RING_11 PF17123.5 PIK38637.1 - 0.00051 19.7 0.4 0.0016 18.1 0.4 1.9 1 0 0 1 1 1 1 RING-like zinc finger PspB PF06667.12 PIK38637.1 - 0.0028 17.7 0.2 0.0028 17.7 0.2 2.1 2 0 0 2 2 2 1 Phage shock protein B DUF5305 PF17231.2 PIK38637.1 - 0.0039 16.6 0.4 0.0064 15.9 0.3 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF5305) BatD PF13584.6 PIK38637.1 - 0.0049 15.8 0.2 0.0057 15.5 0.2 1.1 1 0 0 1 1 1 1 Oxygen tolerance DUF3247 PF11607.8 PIK38637.1 - 0.0072 16.6 0.6 0.019 15.2 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3247) ZNRF_3_ecto PF18212.1 PIK38637.1 - 0.0083 16.1 0.1 0.055 13.5 0.0 2.1 2 0 0 2 2 2 1 ZNRF-3 Ectodomain DUF3923 PF13061.6 PIK38637.1 - 0.017 15.2 1.4 0.017 15.2 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3923) PEN-2 PF10251.9 PIK38637.1 - 0.037 14.4 0.4 0.087 13.2 0.4 1.6 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase TMIE PF16038.5 PIK38637.1 - 0.092 12.6 2.0 2.7 7.9 0.1 2.2 2 0 0 2 2 2 0 TMIE protein HemY_N PF07219.13 PIK38637.1 - 0.66 10.2 2.7 0.81 9.9 1.7 1.6 2 0 0 2 2 2 0 HemY protein N-terminus TssO PF17561.2 PIK38637.1 - 4.1 7.5 7.9 13 5.9 1.9 2.3 1 1 1 2 2 2 0 Type VI secretion system, TssO EF-hand_7 PF13499.6 PIK38638.1 - 3.4e-19 69.1 0.6 4.4e-14 52.7 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK38638.1 - 3.5e-18 63.7 0.8 1.5e-05 24.2 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK38638.1 - 4.4e-16 57.4 0.2 0.00013 21.6 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 PIK38638.1 - 8.4e-12 44.8 1.0 3.4e-06 26.8 0.2 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK38638.1 - 4.1e-09 35.5 1.1 0.00027 20.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 PIK38638.1 - 0.0014 18.5 0.8 0.2 11.6 0.2 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Metallophos PF00149.28 PIK38638.1 - 0.0053 17.3 0.0 0.0087 16.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase OTU PF02338.19 PIK38639.1 - 2.4e-14 53.9 0.5 2.4e-14 53.9 0.5 2.0 3 0 0 3 3 3 1 OTU-like cysteine protease DnaA_N PF11638.8 PIK38639.1 - 0.0063 16.2 0.6 0.78 9.5 0.4 2.7 2 0 0 2 2 2 2 DnaA N-terminal domain Peptidase_C65 PF10275.9 PIK38639.1 - 0.019 14.4 1.4 6.4 6.2 0.0 2.4 2 0 0 2 2 2 0 Peptidase C65 Otubain IF4E PF01652.18 PIK38640.1 - 2.4e-31 108.7 0.0 2.9e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E LLGL PF08366.13 PIK38641.1 - 1e-32 112.5 0.0 2.1e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 LLGL2 WD40 PF00400.32 PIK38641.1 - 1.5e-08 35.1 4.8 0.0049 17.7 0.2 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38641.1 - 1.3e-05 25.4 0.1 0.029 14.7 0.0 3.9 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 PIK38641.1 - 0.0016 16.8 0.0 0.0026 16.1 0.0 1.3 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 PIK38641.1 - 0.19 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain EF-hand_7 PF13499.6 PIK38642.1 - 7.3e-07 29.6 0.7 4.9e-06 26.9 0.5 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK38642.1 - 0.0032 17.3 1.2 0.092 12.6 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK38642.1 - 0.015 14.8 0.7 1.1 8.9 0.1 2.9 2 0 0 2 2 2 0 EF hand UME PF08064.13 PIK38642.1 - 0.033 14.1 0.0 0.057 13.3 0.0 1.5 1 1 0 1 1 1 0 UME (NUC010) domain HHH_9 PF17674.1 PIK38642.1 - 0.066 14.1 0.1 0.5 11.3 0.0 2.3 3 0 0 3 3 3 0 HHH domain EF-hand_4 PF12763.7 PIK38642.1 - 0.17 11.9 0.4 0.94 9.5 0.1 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_6 PF13405.6 PIK38642.1 - 0.23 11.5 1.2 7.4 6.8 0.1 3.2 3 1 0 3 3 3 0 EF-hand domain RhoGEF PF00621.20 PIK38643.1 - 4e-27 95.6 2.3 1.1e-26 94.2 2.3 1.8 1 0 0 1 1 1 1 RhoGEF domain F-box-like PF12937.7 PIK38643.1 - 2.8e-08 33.5 0.4 6.3e-08 32.4 0.4 1.6 1 0 0 1 1 1 1 F-box-like DUF4347 PF14252.6 PIK38643.1 - 7.1e-08 32.5 0.0 1.5e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) DUF4508 PF14969.6 PIK38643.1 - 0.0016 18.6 0.0 0.0063 16.7 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) PH_13 PF16652.5 PIK38643.1 - 0.023 14.5 0.2 0.071 12.9 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain F-box PF00646.33 PIK38643.1 - 0.062 13.2 0.1 0.19 11.6 0.1 1.9 1 0 0 1 1 1 0 F-box domain Arf PF00025.21 PIK38644.1 - 1.8e-32 112.2 0.0 2.7e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 PIK38644.1 - 5.2e-07 29.1 0.2 0.0027 16.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 PIK38644.1 - 3.6e-06 27.2 0.0 6.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK38644.1 - 6.7e-05 22.9 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK38644.1 - 0.00023 20.7 0.0 0.00037 20.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK38644.1 - 0.00023 20.6 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK38644.1 - 0.0051 16.4 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 Ras family DLIC PF05783.11 PIK38644.1 - 0.013 14.3 0.1 0.025 13.4 0.1 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Pkinase PF00069.25 PIK38645.1 - 3.1e-29 102.1 0.0 5e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38645.1 - 2.2e-14 53.4 0.0 3e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK38645.1 - 0.0029 17.0 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK38645.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FAM199X PF15814.5 PIK38645.1 - 2.9 6.9 7.2 4.2 6.3 7.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X Sugar_tr PF00083.24 PIK38646.1 - 5.7e-19 68.3 7.9 2.3e-11 43.2 2.0 3.1 2 1 1 3 3 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK38646.1 - 0.00011 21.2 6.8 0.00011 21.2 6.8 3.2 2 1 0 2 2 1 1 Major Facilitator Superfamily Gaa1 PF04114.14 PIK38646.1 - 0.0025 16.9 0.1 0.0025 16.9 0.1 2.2 2 0 0 2 2 2 1 Gaa1-like, GPI transamidase component Orf78 PF06024.12 PIK38646.1 - 0.0026 18.0 0.7 0.0072 16.6 0.7 1.8 1 0 0 1 1 1 1 Orf78 (ac78) DUF3464 PF11947.8 PIK38646.1 - 0.0062 16.3 0.4 0.018 14.8 0.4 1.8 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 RRN3 PF05327.11 PIK38646.1 - 0.086 11.4 25.1 0.13 10.8 25.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 PIK38646.1 - 0.29 10.2 36.2 0.42 9.7 36.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) OMP_b-brl_2 PF13568.6 PIK38646.1 - 0.52 10.3 0.0 0.52 10.3 0.0 2.3 2 1 0 2 2 1 0 Outer membrane protein beta-barrel domain DUF2796 PF10986.8 PIK38646.1 - 0.59 10.1 7.1 1.1 9.2 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Presenilin PF01080.17 PIK38646.1 - 0.8 8.4 0.0 0.8 8.4 0.0 2.7 3 0 0 3 3 2 0 Presenilin NOA36 PF06524.12 PIK38646.1 - 1.2 8.4 32.1 2.2 7.5 32.1 1.4 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 PIK38646.1 - 2.2 6.4 21.6 3.2 5.9 21.6 1.1 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 PIK38646.1 - 2.4 8.0 10.0 3.8 7.3 10.0 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CitMHS PF03600.16 PIK38646.1 - 2.6 7.2 0.0 2.6 7.2 0.0 2.4 2 1 0 2 2 1 0 Citrate transporter DNA_pol_phi PF04931.13 PIK38646.1 - 4.2 5.3 37.6 6.1 4.8 37.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cnd2 PF05786.14 PIK38646.1 - 8.6 4.9 20.9 12 4.4 20.9 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Sugar_tr PF00083.24 PIK38648.1 - 5e-13 48.7 0.5 7.2e-08 31.7 0.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK38648.1 - 1.9e-05 23.8 5.1 0.00017 20.7 3.7 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TPR_10 PF13374.6 PIK38648.1 - 0.088 12.7 0.2 0.27 11.1 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat ThrE_2 PF12821.7 PIK38648.1 - 0.11 12.6 2.0 0.32 11.2 0.3 2.1 2 0 0 2 2 2 0 Threonine/Serine exporter, ThrE IRK PF01007.20 PIK38648.1 - 1.6 8.5 6.4 2.5 7.9 2.3 2.9 2 1 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain MFS_1 PF07690.16 PIK38649.1 - 3.2e-07 29.6 8.9 4.1e-07 29.3 8.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK38649.1 - 1.4e-05 24.1 7.7 1.8e-05 23.8 7.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1440 PF07274.12 PIK38649.1 - 0.12 12.8 0.3 0.19 12.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) MAD PF05557.13 PIK38650.1 - 0.00012 20.7 21.8 0.00012 20.7 21.8 7.0 2 2 4 6 6 6 1 Mitotic checkpoint protein gpW PF02831.15 PIK38650.1 - 0.089 12.7 0.9 0.54 10.2 0.9 2.5 1 0 0 1 1 1 0 gpW DUF4407 PF14362.6 PIK38650.1 - 0.13 11.6 125.2 0.19 11.1 12.4 8.4 2 2 6 8 8 8 0 Domain of unknown function (DUF4407) DUF4407 PF14362.6 PIK38651.1 - 5.1 6.4 46.0 0.046 13.1 11.8 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Asp-B-Hydro_N PF05279.11 PIK38652.1 - 0.002 18.3 8.7 0.0022 18.1 8.7 1.1 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region Tox-ODYAM1 PF15642.6 PIK38652.1 - 0.023 13.7 8.4 0.028 13.4 8.4 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus polyprenyl_synt PF00348.17 PIK38652.1 - 0.026 13.6 0.2 0.026 13.6 0.2 2.2 2 1 0 2 2 2 0 Polyprenyl synthetase SpecificRecomb PF10136.9 PIK38652.1 - 0.031 12.6 6.0 0.038 12.3 6.0 1.0 1 0 0 1 1 1 0 Site-specific recombinase Hid1 PF12722.7 PIK38652.1 - 0.059 11.5 6.8 0.072 11.2 6.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0242 PF06785.11 PIK38652.1 - 0.1 12.7 17.1 0.15 12.2 17.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMCO5 PF14992.6 PIK38652.1 - 0.12 11.9 23.0 0.18 11.4 23.0 1.1 1 0 0 1 1 1 0 TMCO5 family LUC7 PF03194.15 PIK38652.1 - 0.36 10.5 15.0 0.46 10.1 15.0 1.1 1 0 0 1 1 1 0 LUC7 N_terminus FAM184 PF15665.5 PIK38652.1 - 0.39 10.5 26.3 0.69 9.6 26.3 1.4 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Presenilin PF01080.17 PIK38652.1 - 0.56 8.9 5.7 0.72 8.6 5.7 1.2 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 PIK38652.1 - 0.62 9.8 8.8 0.78 9.5 8.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ALMT PF11744.8 PIK38652.1 - 0.67 8.7 5.0 0.8 8.5 5.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2362 PF10154.9 PIK38652.1 - 0.68 8.8 12.5 0.89 8.4 12.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) PepSY_TM_like_2 PF16357.5 PIK38652.1 - 0.74 9.8 5.2 1.8 8.5 0.1 2.1 1 1 1 2 2 2 0 Putative PepSY_TM-like LemA PF04011.12 PIK38652.1 - 0.8 9.5 11.0 4.5 7.1 11.0 1.9 1 1 0 1 1 1 0 LemA family LMBR1 PF04791.16 PIK38652.1 - 1.1 8.1 3.8 1.3 7.9 3.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MotA_ExbB PF01618.16 PIK38652.1 - 1.4 8.7 7.1 5.7 6.7 1.5 2.3 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family VSG_B PF13206.6 PIK38652.1 - 1.6 7.9 10.7 2 7.6 10.7 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain POX PF07526.11 PIK38652.1 - 1.9 9.1 12.8 3 8.4 12.8 1.3 1 0 0 1 1 1 0 Associated with HOX DUF745 PF05335.13 PIK38652.1 - 3.7 7.2 15.7 2.4 7.9 14.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF1690 PF07956.11 PIK38652.1 - 3.9 7.9 19.6 7.3 7.0 19.3 1.6 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Pannexin_like PF12534.8 PIK38652.1 - 8.9 5.3 7.5 11 5.0 7.5 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 LIN37 PF15306.6 PIK38652.1 - 9.1 6.5 12.3 19 5.4 12.3 1.5 1 1 0 1 1 1 0 LIN37 DUF883 PF05957.13 PIK38652.1 - 9.2 6.9 13.1 30 5.3 6.7 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) SNCAIP_SNCA_bd PF16700.5 PIK38653.1 - 2.1 8.1 10.8 0.37 10.5 0.5 3.4 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain FixH PF05751.11 PIK38654.1 - 0.096 12.7 0.6 0.44 10.6 0.0 2.0 2 0 0 2 2 2 0 FixH FUSC PF04632.12 PIK38654.1 - 5.3 5.4 16.4 3.7 6.0 8.7 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family PACT_coil_coil PF10495.9 PIK38655.1 - 5.8e-24 84.5 0.3 5.8e-24 84.5 0.3 6.3 5 2 0 5 5 5 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein ATG16 PF08614.11 PIK38655.1 - 0.00018 21.8 22.7 0.00018 21.8 22.7 12.1 3 2 10 13 13 13 1 Autophagy protein 16 (ATG16) Fibrinogen_C PF00147.18 PIK38657.1 - 3.5e-66 223.2 1.5 3.5e-66 223.2 1.5 1.6 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain SelP_N PF04592.14 PIK38657.1 - 0.45 9.9 7.9 0.94 8.8 7.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region HGTP_anticodon PF03129.20 PIK38658.1 - 1.9e-21 76.0 0.0 6.2e-21 74.4 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain WHEP-TRS PF00458.20 PIK38658.1 - 1.9e-10 40.8 6.0 4.7e-10 39.5 6.0 1.7 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2b PF00587.25 PIK38658.1 - 4.8e-10 39.7 0.1 1.4e-09 38.2 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PAZ PF02170.22 PIK38660.1 - 0.018 14.9 0.3 0.036 13.9 0.3 1.5 1 0 0 1 1 1 0 PAZ domain AAA_28 PF13521.6 PIK38661.1 - 0.02 15.1 0.0 3 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 PIK38661.1 - 0.068 13.1 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 PIK38661.1 - 0.13 11.3 0.0 0.55 9.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Parvo_NS1 PF01057.17 PIK38661.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 PIK38661.1 - 0.15 12.5 0.0 0.77 10.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase Xan_ur_permease PF00860.20 PIK38662.1 - 2.6e-41 141.6 6.7 3.5e-41 141.2 6.7 1.1 1 0 0 1 1 1 1 Permease family BRCT PF00533.26 PIK38663.1 - 1.3e-12 47.9 0.0 1.2e-05 25.6 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 PIK38663.1 - 2.6e-08 33.7 0.0 1.2e-07 31.5 0.0 2.1 2 1 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 PIK38663.1 - 1.2e-06 28.4 0.0 6.9e-05 22.7 0.0 2.5 2 0 0 2 2 2 1 twin BRCT domain BRCT_2 PF16589.5 PIK38663.1 - 5.2e-05 23.6 0.0 0.048 14.1 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 PIK38663.1 - 0.095 13.0 0.0 21 5.5 0.0 2.4 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 PIK38663.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain SH3_9 PF14604.6 PIK38664.1 - 3.8e-34 116.3 4.9 2.2e-10 40.2 0.1 3.9 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 PIK38664.1 - 7e-34 115.3 0.0 7.7e-12 44.7 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 PIK38664.1 - 1.7e-17 62.7 0.5 0.00013 21.4 0.2 4.3 3 1 0 3 3 3 3 SH3 domain fn3 PF00041.21 PIK38664.1 - 6.9e-13 48.8 2.6 1.9e-06 28.1 0.0 4.7 3 1 0 3 3 3 2 Fibronectin type III domain TrkA_C PF02080.21 PIK38664.1 - 0.0063 16.3 0.5 2.4 8.0 0.0 3.0 3 0 0 3 3 3 1 TrkA-C domain Pur_ac_phosph_N PF16656.5 PIK38664.1 - 0.0069 16.9 0.1 0.7 10.5 0.0 3.9 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain DUF1870 PF08965.10 PIK38664.1 - 0.08 13.0 2.1 0.28 11.2 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) FCH PF00611.23 PIK38664.1 - 0.16 12.3 7.5 0.14 12.5 5.2 2.1 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain DUF4091 PF13320.6 PIK38664.1 - 0.2 11.8 5.5 0.2 11.8 0.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4091) TPR_MLP1_2 PF07926.12 PIK38664.1 - 0.49 10.5 21.3 2.3 8.3 21.3 2.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Vac_Fusion PF02346.16 PIK38664.1 - 2 8.1 5.2 17 5.1 0.2 2.9 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 zf-CCHC PF00098.23 PIK38666.1 - 3.2e-06 27.0 16.1 0.0019 18.2 3.3 3.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38666.1 - 5.1e-05 22.9 14.1 0.26 11.1 1.0 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38666.1 - 0.0017 18.1 0.2 0.0017 18.1 0.2 3.0 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK38666.1 - 0.46 10.8 12.2 0.27 11.5 6.8 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK38666.1 - 0.84 9.4 12.9 0.52 10.1 0.3 4.1 4 0 0 4 4 4 0 C2H2 zinc-finger DUF4218 PF13960.6 PIK38667.1 - 0.0066 16.1 0.1 0.015 14.9 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4218) WRW PF10206.9 PIK38668.1 - 9.5e-15 54.8 0.0 1.1e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f F1F0-ATPsyn_F PF10791.9 PIK38668.1 - 0.015 15.8 0.0 0.019 15.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi ENTH PF01417.20 PIK38669.1 - 2.8e-10 40.3 0.2 1.4e-09 38.1 0.0 2.3 2 1 0 2 2 2 1 ENTH domain Zip PF02535.22 PIK38670.1 - 1e-12 47.9 0.3 1.2e-11 44.5 0.1 2.0 2 0 0 2 2 2 2 ZIP Zinc transporter PWI PF01480.17 PIK38671.1 - 5.6e-05 23.4 0.1 0.0027 18.0 0.1 2.6 1 1 1 2 2 2 1 PWI domain DUF1539 PF07560.11 PIK38671.1 - 0.032 14.3 2.0 1.3 9.1 1.3 2.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) SRP-alpha_N PF04086.13 PIK38671.1 - 0.15 11.9 22.4 0.23 11.3 22.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Sulfatase PF00884.23 PIK38672.1 - 4.4e-46 157.7 0.5 7.1e-46 157.0 0.5 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK38672.1 - 2.5e-05 24.1 0.3 0.17 11.5 0.0 2.7 3 0 0 3 3 3 2 Type I phosphodiesterase / nucleotide pyrophosphatase MFS_1 PF07690.16 PIK38673.1 - 5.1e-13 48.7 5.1 9.4e-13 47.8 5.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 PIK38673.1 - 0.00077 18.3 0.8 0.00092 18.1 0.8 1.1 1 0 0 1 1 1 1 LacY proton/sugar symporter Transthyretin PF00576.21 PIK38673.1 - 0.093 13.4 0.0 0.15 12.8 0.0 1.2 1 0 0 1 1 1 0 HIUase/Transthyretin family MFS_1 PF07690.16 PIK38674.1 - 0.21 10.5 29.3 0.12 11.2 11.5 2.3 1 1 1 2 2 2 0 Major Facilitator Superfamily Tetraspanin PF00335.20 PIK38674.1 - 7.7 6.2 12.5 5.2 6.7 6.1 2.7 3 0 0 3 3 3 0 Tetraspanin family DUF4524 PF15025.6 PIK38675.1 - 5e-35 120.4 1.8 1.9e-34 118.5 0.2 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4524) DUF4520 PF15016.6 PIK38675.1 - 7.3e-15 54.8 0.2 5.4e-11 42.4 0.0 3.7 3 1 0 3 3 3 2 Domain of unknown function (DUF4520) Peripla_BP_7 PF18610.1 PIK38675.1 - 0.13 12.4 0.3 0.28 11.4 0.3 1.5 1 0 0 1 1 1 0 Periplasmic binding protein domain tRNA-synt_1g PF09334.11 PIK38676.1 - 1.8e-103 346.3 0.1 4.7e-103 345.0 0.1 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 PIK38676.1 - 3.8e-15 55.2 9.3 4.6e-06 25.2 0.1 3.6 1 1 3 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 PIK38676.1 - 2.9e-08 33.4 0.0 0.0013 18.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Dimer_Tnp_hAT PF05699.14 PIK38676.1 - 3.1e-06 26.9 0.1 7.2e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Anticodon_1 PF08264.13 PIK38676.1 - 1.5e-05 25.0 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA ETX_MTX2 PF03318.13 PIK38677.1 - 2.7e-07 30.6 3.4 3.2e-07 30.4 3.4 1.1 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK38677.1 - 3.8e-06 26.4 1.4 4.8e-06 26.0 1.4 1.1 1 0 0 1 1 1 1 Aerolysin toxin DUF5300 PF17224.3 PIK38677.1 - 0.05 13.9 0.5 0.62 10.3 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5300) C4 PF01413.19 PIK38678.1 - 1.1e-71 238.2 4.6 1.7e-35 121.8 0.6 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 PIK38678.1 - 2.6e-32 110.4 107.1 4.8e-09 35.8 21.2 5.6 1 1 4 5 5 5 5 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK38679.1 - 3.3e-77 254.2 258.2 6.4e-10 38.6 15.9 12.4 6 3 6 12 12 12 11 Collagen triple helix repeat (20 copies) SRCR PF00530.18 PIK38680.1 - 2.8e-107 351.9 17.7 1.1e-30 106.1 1.3 4.2 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38680.1 - 1.7e-24 86.2 12.2 1.7e-05 25.3 0.0 4.8 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK38680.1 - 2.4e-10 40.9 0.0 0.39 11.3 0.0 4.4 4 0 0 4 4 4 3 Hepsin, SRCR domain YecR PF13992.6 PIK38680.1 - 0.00018 21.8 7.6 0.33 11.3 0.1 4.8 4 0 0 4 4 4 2 YecR-like lipoprotein Shisa PF13908.6 PIK38680.1 - 4.3 7.5 20.9 0.23 11.7 13.6 2.2 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Sushi PF00084.20 PIK38681.1 - 1.4e-08 35.2 1.4 4.6e-07 30.3 0.2 3.8 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) SEA PF01390.20 PIK38681.1 - 6.7e-07 29.4 0.0 2e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 SEA domain EGF_CA PF07645.15 PIK38681.1 - 0.0043 17.2 9.1 0.0043 17.2 9.1 3.1 3 0 0 3 3 3 1 Calcium-binding EGF domain cEGF PF12662.7 PIK38681.1 - 3.2 7.8 15.4 9.3 6.3 0.2 4.4 3 0 0 3 3 3 0 Complement Clr-like EGF-like EGF PF00008.27 PIK38681.1 - 3.8 7.9 19.6 0.3 11.4 4.5 3.3 2 1 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 PIK38681.1 - 4.9 7.6 20.5 4.2 7.8 7.1 2.7 2 0 0 2 2 2 0 EGF-like domain SEA PF01390.20 PIK38682.1 - 1.1e-06 28.7 0.2 2e-06 27.9 0.2 1.4 1 0 0 1 1 1 1 SEA domain Sushi PF00084.20 PIK38683.1 - 2.1e-20 73.1 31.0 3.5e-08 33.9 2.4 5.6 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) SEA PF01390.20 PIK38683.1 - 1e-07 32.0 1.4 1e-07 32.0 1.4 3.5 4 0 0 4 4 4 1 SEA domain DUF1859 PF08948.10 PIK38683.1 - 0.12 12.3 4.1 40 4.2 0.0 4.7 5 1 1 6 6 6 0 Domain of unknown function (DUF1859) Melittin PF01372.17 PIK38683.1 - 0.17 11.9 0.5 94 3.3 0.1 4.0 3 0 0 3 3 3 0 Melittin NOD2_WH PF17779.1 PIK38683.1 - 1.2 9.5 2.9 4.1e+02 1.4 0.0 4.4 4 0 0 4 4 4 0 NOD2 winged helix domain RVT_1 PF00078.27 PIK38685.1 - 5.4e-23 81.7 0.0 1.1e-22 80.6 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK38685.1 - 1.4e-06 28.8 0.0 3.9e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK38685.1 - 1.4e-05 25.6 0.0 4.3e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease Pim PF16765.5 PIK38685.1 - 0.07 13.3 0.1 0.43 10.8 0.0 2.4 3 0 0 3 3 3 0 Pesticin immunity protein RhoGAP PF00620.27 PIK38686.1 - 9.6e-34 116.4 0.0 2.8e-33 114.9 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain Clat_adaptor_s PF01217.20 PIK38688.1 - 3.1e-40 137.4 2.9 3.3e-40 137.3 2.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain S1 PF00575.23 PIK38689.1 - 3e-18 65.9 0.1 5.8e-18 65.0 0.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 PIK38689.1 - 1.3e-15 57.5 0.0 2.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 PIK38689.1 - 1.1e-05 25.6 0.0 1.6e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 C2-set_2 PF08205.12 PIK38690.1 - 2e-10 40.6 0.6 0.00047 20.2 0.3 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK38690.1 - 3.3e-09 37.2 0.6 0.074 13.7 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK38690.1 - 3.2e-08 33.8 0.8 0.001 19.3 0.1 3.3 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK38690.1 - 2.2e-07 30.8 0.1 0.27 11.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 PIK38690.1 - 6.9e-06 26.2 0.6 0.13 12.4 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK38690.1 - 0.00067 20.0 2.3 0.99 9.8 0.6 2.9 2 1 1 3 3 3 2 Immunoglobulin C1-set domain V-set PF07686.17 PIK38690.1 - 0.0031 17.7 0.1 5.6 7.2 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin V-set domain S1 PF00575.23 PIK38691.1 - 0.0041 17.4 0.0 0.0043 17.4 0.0 1.1 1 0 0 1 1 1 1 S1 RNA binding domain Neur_chan_LBD PF02931.23 PIK38692.1 - 7e-32 110.6 0.2 9.4e-32 110.2 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK38692.1 - 1e-12 48.7 5.7 2.8e-11 44.0 6.8 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region LMF1 PF06762.14 PIK38693.1 - 6.5e-127 424.3 6.3 7.9e-127 424.0 6.3 1.0 1 0 0 1 1 1 1 Lipase maturation factor TraQ PF09679.10 PIK38693.1 - 2.7 8.0 8.5 4.3 7.3 0.1 2.6 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) MBF2 PF15868.5 PIK38694.1 - 1.7e-15 57.3 0.3 2.3e-15 56.9 0.3 1.2 1 0 0 1 1 1 1 Transcription activator MBF2 DUF2064 PF09837.9 PIK38695.1 - 0.034 13.9 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) Atrophin-1 PF03154.15 PIK38696.1 - 0.55 8.5 6.5 0.65 8.2 6.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Zip PF02535.22 PIK38696.1 - 3 7.0 3.9 3.9 6.6 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MBF2 PF15868.5 PIK38697.1 - 6.1e-21 74.7 0.1 1.1e-20 74.0 0.1 1.4 1 1 0 1 1 1 1 Transcription activator MBF2 ELO PF01151.18 PIK38698.1 - 9.5e-12 45.0 0.8 1.2e-11 44.7 0.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Glyco_hydro_31 PF01055.26 PIK38699.1 - 9.5e-137 456.8 0.0 1.4e-91 307.9 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK38699.1 - 2.5e-28 98.6 0.1 4.4e-28 97.8 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 PIK38699.1 - 7.9e-13 48.1 9.3 1.8e-12 46.9 9.3 1.6 1 0 0 1 1 1 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 PIK38699.1 - 2.1e-12 47.2 1.9 8.6e-12 45.2 0.9 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 PIK38699.1 - 5.4e-05 23.4 1.5 0.00012 22.3 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) Sipho_Gp157 PF05565.11 PIK38700.1 - 0.00092 19.3 1.3 0.002 18.2 1.3 1.6 1 0 0 1 1 1 1 Siphovirus Gp157 TSC22 PF01166.18 PIK38700.1 - 0.0026 18.0 0.1 0.04 14.2 0.4 2.7 2 1 1 3 3 2 1 TSC-22/dip/bun family MIS13 PF08202.11 PIK38700.1 - 0.0039 16.5 4.5 0.0063 15.8 4.5 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF1664 PF07889.12 PIK38700.1 - 0.01 15.8 4.9 0.01 15.8 4.9 2.2 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4140 PF13600.6 PIK38700.1 - 0.022 15.2 5.2 0.3 11.5 1.5 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ATG16 PF08614.11 PIK38700.1 - 0.022 15.0 4.8 0.022 15.0 4.8 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 PIK38700.1 - 0.047 13.8 1.1 0.047 13.8 1.1 3.2 3 1 1 4 4 3 0 bZIP transcription factor CENP-F_leu_zip PF10473.9 PIK38700.1 - 0.058 13.4 10.4 0.092 12.8 7.8 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fzo_mitofusin PF04799.13 PIK38700.1 - 0.063 12.8 4.3 0.099 12.2 3.6 1.7 1 1 0 1 1 1 0 fzo-like conserved region Hrs_helical PF12210.8 PIK38700.1 - 0.085 13.4 5.2 5.6 7.6 0.7 3.5 3 2 1 4 4 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate YabA PF06156.13 PIK38700.1 - 0.093 13.4 4.9 0.21 12.3 3.4 2.2 2 1 0 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 PIK38700.1 - 0.15 12.3 7.2 0.87 9.9 1.0 3.8 2 1 2 4 4 4 0 Homeobox associated leucine zipper Snapin_Pallidin PF14712.6 PIK38700.1 - 0.18 12.2 10.6 0.058 13.8 2.0 3.1 2 1 0 3 3 3 0 Snapin/Pallidin BLOC1_2 PF10046.9 PIK38700.1 - 0.18 12.1 5.7 0.061 13.6 2.1 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MbeD_MobD PF04899.12 PIK38700.1 - 0.26 11.4 3.3 0.26 11.4 0.8 2.3 2 1 0 2 2 1 0 MbeD/MobD like Prominin PF05478.11 PIK38700.1 - 0.31 8.9 5.6 0.42 8.5 5.6 1.2 1 0 0 1 1 1 0 Prominin ZapB PF06005.12 PIK38700.1 - 0.32 11.5 11.5 0.066 13.7 4.9 3.0 2 2 1 3 3 3 0 Cell division protein ZapB DUF4047 PF13256.6 PIK38700.1 - 0.47 10.7 6.2 0.075 13.2 1.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) SlyX PF04102.12 PIK38700.1 - 0.52 11.0 3.5 0.81 10.4 2.0 2.2 1 1 0 1 1 1 0 SlyX DivIC PF04977.15 PIK38700.1 - 0.72 9.7 6.7 0.094 12.5 1.4 2.4 3 1 0 3 3 1 0 Septum formation initiator DUF3847 PF12958.7 PIK38700.1 - 0.72 10.0 5.1 2.5 8.3 2.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3847) Cortex-I_coil PF09304.10 PIK38700.1 - 0.8 10.0 8.3 0.95 9.7 6.7 2.0 1 1 0 1 1 1 0 Cortexillin I, coiled coil Lectin_N PF03954.14 PIK38700.1 - 0.81 9.4 8.2 0.87 9.3 5.9 2.1 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain FAM184 PF15665.5 PIK38700.1 - 1.1 9.0 10.9 0.31 10.8 4.7 2.4 1 1 0 2 2 2 0 Family with sequence similarity 184, A and B DUF4200 PF13863.6 PIK38700.1 - 1.2 9.6 10.9 9 6.7 5.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin-6_N PF09177.11 PIK38700.1 - 1.2 9.8 7.5 0.63 10.6 4.6 2.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Jnk-SapK_ap_N PF09744.9 PIK38700.1 - 1.5 9.0 13.1 0.49 10.6 7.9 2.3 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 XhlA PF10779.9 PIK38700.1 - 2.3 8.5 5.1 2.3 8.5 2.1 2.4 2 1 1 3 3 3 0 Haemolysin XhlA JIP_LZII PF16471.5 PIK38700.1 - 2.5 8.3 9.0 1.2 9.4 1.6 3.4 2 2 1 3 3 3 0 JNK-interacting protein leucine zipper II Uds1 PF15456.6 PIK38700.1 - 4.8 7.4 10.8 1.6 8.9 3.3 2.7 2 1 0 2 2 2 0 Up-regulated During Septation PRKG1_interact PF15898.5 PIK38700.1 - 4.9 8.1 12.3 0.3 12.0 3.8 2.8 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain HAUS6_N PF14661.6 PIK38700.1 - 6.1 6.4 10.2 0.62 9.6 5.4 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus AMP-binding_C PF13193.6 PIK38701.1 - 2.6e-22 79.6 0.8 4e-22 79.0 0.8 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK38701.1 - 5.8e-15 54.8 0.0 7.5e-15 54.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.28 PIK38702.1 - 2.6e-32 112.0 0.0 3e-32 111.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 PIK38703.1 - 3.1e-16 59.0 0.2 5.2e-16 58.3 0.2 1.4 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Lipase_GDSL_2 PF13472.6 PIK38704.1 - 1e-25 91.2 0.0 1.3e-25 90.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK38704.1 - 3.7e-15 56.5 0.0 6.5e-15 55.6 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase FSA_C PF10479.9 PIK38704.1 - 0.11 10.6 0.1 0.15 10.2 0.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Tetraspanin PF00335.20 PIK38705.1 - 3.3e-20 72.8 11.5 3.7e-20 72.6 11.5 1.1 1 0 0 1 1 1 1 Tetraspanin family Phage_holin_3_6 PF07332.11 PIK38705.1 - 0.049 13.7 4.1 0.11 12.5 2.2 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CRA PF06589.11 PIK38705.1 - 0.074 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) MAP17 PF15807.5 PIK38705.1 - 0.11 12.7 6.2 0.57 10.4 2.2 2.2 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF3043 PF11241.8 PIK38705.1 - 0.76 9.8 1.8 1.5 8.9 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Herpes_LMP1 PF05297.11 PIK38705.1 - 1.7 7.8 7.3 2.5 7.2 7.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) MARVEL PF01284.23 PIK38705.1 - 2.9 7.9 11.8 3.4 7.7 10.2 1.9 1 1 1 2 2 2 0 Membrane-associating domain TssN PF17555.2 PIK38705.1 - 3 7.1 7.7 4.4 6.6 7.7 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN I_LWEQ PF01608.17 PIK38706.1 - 2.7e-51 173.8 22.2 4.3e-49 166.7 15.9 2.0 2 0 0 2 2 2 2 I/LWEQ domain DUF3025 PF11227.8 PIK38706.1 - 0.044 13.6 0.8 0.077 12.8 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3025) Serine_rich PF08824.10 PIK38706.1 - 0.68 9.9 6.1 0.92 9.5 2.7 2.1 1 1 1 2 2 2 0 Serine rich protein interaction domain Phycobilisome PF00502.19 PIK38706.1 - 2.7 7.9 11.4 1.6 8.7 1.0 2.8 1 1 2 3 3 3 0 Phycobilisome protein DUF2564 PF10819.8 PIK38706.1 - 7.3 7.1 21.7 7.4 7.0 1.3 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF2564) VBS PF08913.10 PIK38707.1 - 1.5e-35 122.3 38.8 2e-26 92.8 1.0 8.0 7 2 1 8 8 8 4 Vinculin Binding Site I_LWEQ PF01608.17 PIK38707.1 - 3.6e-14 53.3 63.5 0.0022 18.2 6.1 10.8 6 4 5 11 11 11 7 I/LWEQ domain LOH1CR12 PF10158.9 PIK38707.1 - 0.00048 20.2 4.9 2.4 8.2 0.3 5.1 4 1 0 4 4 4 1 Tumour suppressor protein GCIP PF13324.6 PIK38707.1 - 0.0018 17.9 12.1 0.27 10.8 0.0 5.5 6 1 0 6 6 6 2 Grap2 and cyclin-D-interacting PARP_reg PF02877.14 PIK38707.1 - 0.027 14.6 0.7 0.8 9.8 0.0 3.6 3 0 0 3 3 3 0 Poly(ADP-ribose) polymerase, regulatory domain YtxH PF12732.7 PIK38707.1 - 0.041 14.4 15.6 21 5.7 0.1 7.7 9 0 0 9 9 9 0 YtxH-like protein Synuclein PF01387.17 PIK38707.1 - 0.045 13.9 0.4 0.045 13.9 0.4 4.2 5 0 0 5 5 5 0 Synuclein DUF1525 PF07511.11 PIK38707.1 - 0.06 13.5 1.6 42 4.3 0.0 5.3 5 0 0 5 5 5 0 Protein of unknown function (DUF1525) FliJ PF02050.16 PIK38707.1 - 0.19 12.0 3.1 1.5 9.0 0.0 3.8 3 0 0 3 3 3 0 Flagellar FliJ protein Trns_repr_metal PF02583.17 PIK38707.1 - 0.25 11.7 5.0 1.3 9.5 0.1 4.1 2 1 1 3 3 3 0 Metal-sensitive transcriptional repressor GIT1_C PF12205.8 PIK38707.1 - 0.84 9.8 25.0 0.44 10.7 0.4 7.7 7 2 2 9 9 9 0 G protein-coupled receptor kinase-interacting protein 1 C term SipA_VBS PF17985.1 PIK38707.1 - 1.3 9.1 12.7 5.9 7.0 1.1 5.2 4 0 0 4 4 4 0 SipA vinculin binding site Talin_middle PF09141.10 PIK38708.1 - 1.6e-43 148.5 9.0 1.6e-43 148.5 9.0 5.0 2 1 1 4 4 3 2 Talin, middle domain FERM_M PF00373.18 PIK38708.1 - 2.3e-25 89.3 0.1 2.3e-25 89.3 0.1 2.4 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 PIK38708.1 - 2.7e-22 78.5 2.7 2.2e-19 69.1 0.5 2.8 2 0 0 2 2 2 2 FERM N-terminal domain FERM_f0 PF16511.5 PIK38708.1 - 2.9e-16 59.5 0.5 2.8e-14 53.2 0.2 3.2 3 0 0 3 3 3 1 N-terminal or F0 domain of Talin-head FERM I_LWEQ PF01608.17 PIK38708.1 - 8.4e-14 52.1 57.4 2e-05 24.8 5.3 7.0 5 2 2 8 8 8 5 I/LWEQ domain IRS PF02174.17 PIK38708.1 - 6.4e-05 22.8 0.0 0.00018 21.3 0.0 1.7 1 0 0 1 1 1 1 PTB domain (IRS-1 type) RA PF00788.23 PIK38708.1 - 0.008 16.8 0.1 0.019 15.6 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DUF1525 PF07511.11 PIK38708.1 - 0.32 11.2 7.7 0.12 12.5 1.7 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1525) Coat_F PF07875.12 PIK38708.1 - 0.32 11.3 0.0 0.32 11.3 0.0 3.9 4 0 0 4 4 4 0 Coat F domain HTH_57 PF18679.1 PIK38708.1 - 0.62 10.4 3.9 6.2 7.2 0.2 3.4 2 1 0 2 2 2 0 ThcOx helix turn helix domain CHAD PF05235.14 PIK38708.1 - 10 6.1 15.9 24 4.8 12.7 2.8 2 1 0 2 2 2 0 CHAD domain Fibrinogen_C PF00147.18 PIK38709.1 - 1.5e-46 158.9 0.6 1.8e-46 158.7 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38710.1 - 1.8e-66 224.1 7.8 2.2e-66 223.8 7.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain C6 PF01681.17 PIK38710.1 - 0.013 16.0 0.3 0.044 14.3 0.0 1.9 2 0 0 2 2 2 0 C6 domain DUF2121 PF09894.9 PIK38711.1 - 0.11 12.0 0.1 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) RVT_1 PF00078.27 PIK38712.1 - 0.0003 20.4 0.1 0.00065 19.3 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Annexin PF00191.20 PIK38713.1 - 6.4e-27 93.4 0.4 3.7e-20 71.7 0.1 3.1 3 0 0 3 3 3 3 Annexin Annexin PF00191.20 PIK38714.1 - 1.5e-46 156.3 7.0 4.3e-19 68.3 0.1 4.1 4 0 0 4 4 4 4 Annexin Annexin PF00191.20 PIK38716.1 - 7.2e-42 141.3 0.9 5.3e-18 64.8 0.2 3.2 3 0 0 3 3 3 3 Annexin Myb_DNA-bind_7 PF15963.5 PIK38716.1 - 0.11 12.4 1.5 0.2 11.5 0.1 2.2 3 0 0 3 3 3 0 Myb DNA-binding like ANAPC4_WD40 PF12894.7 PIK38717.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Mic1 PF07035.12 PIK38718.1 - 7.3e-70 233.7 2.0 2.9e-69 231.8 0.4 2.0 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like Fibrinogen_C PF00147.18 PIK38719.1 - 4e-58 196.8 4.5 4.9e-58 196.5 4.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain THAP PF05485.12 PIK38723.1 - 0.035 15.0 0.1 0.058 14.3 0.1 1.4 1 0 0 1 1 1 0 THAP domain RVT_1 PF00078.27 PIK38724.1 - 1.3e-05 24.8 0.0 4e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_10 PF16588.5 PIK38725.1 - 0.0039 16.9 0.8 0.01 15.5 0.8 1.7 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 PIK38725.1 - 0.11 12.6 13.8 0.39 10.9 2.5 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38725.1 - 0.6 9.9 6.2 3 7.6 0.3 2.5 1 1 1 2 2 2 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK38726.1 - 9.9e-09 35.1 0.2 1.4e-08 34.6 0.2 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK38726.1 - 0.014 15.2 0.0 0.04 13.7 0.0 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Carbam_trans_C PF16861.5 PIK38727.1 - 0.05 13.2 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus zf-C2H2 PF00096.26 PIK38728.1 - 8.5e-28 95.2 48.7 4.5e-05 23.7 2.3 7.9 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK38728.1 - 1.6e-17 62.6 49.4 0.0007 20.2 0.8 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK38728.1 - 4.6e-16 58.4 48.9 1.7e-07 31.4 1.5 8.4 9 0 0 9 9 9 4 Zinc-finger double domain zf-H2C2_5 PF13909.6 PIK38728.1 - 1.6e-07 31.0 31.2 3.8e-05 23.3 5.1 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain DUF3268 PF11672.8 PIK38728.1 - 0.0033 17.7 13.3 0.026 14.9 0.7 2.6 2 1 0 2 2 2 2 zinc-finger-containing domain zf-C2H2_6 PF13912.6 PIK38728.1 - 0.066 13.2 0.4 0.066 13.2 0.4 7.1 7 1 0 7 7 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK38728.1 - 0.22 11.9 29.7 2.1 8.7 0.0 5.2 3 2 0 3 3 3 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 PIK38728.1 - 0.25 11.2 9.1 3.1 7.7 0.4 3.3 3 0 0 3 3 3 0 GAGA factor zf-Di19 PF05605.12 PIK38728.1 - 0.29 11.4 30.1 2.8 8.3 0.1 4.6 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK38728.1 - 0.33 11.3 33.7 1.6 9.1 2.1 6.4 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf_C2H2_13 PF18508.1 PIK38728.1 - 1.2 8.7 4.7 13 5.4 0.0 3.1 3 0 0 3 3 3 0 Zinc finger domain zf-C2H2_7 PF15269.6 PIK38728.1 - 2.6 8.2 21.0 0.42 10.7 1.3 4.4 3 2 2 5 5 5 0 Zinc-finger Actin_micro PF17003.5 PIK38728.1 - 4.6 6.3 18.1 0.71 9.0 0.6 4.5 3 2 2 5 5 5 0 Putative actin-like family zf-C2H2_3rep PF18868.1 PIK38728.1 - 8 7.2 20.6 3 8.5 0.1 5.3 4 2 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats Ion_trans_2 PF07885.16 PIK38729.1 - 1.5e-20 72.9 21.4 3.9e-14 52.4 9.4 2.4 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 PIK38729.1 - 0.005 16.1 9.0 0.005 16.1 9.0 1.9 1 1 0 2 2 2 1 Ion transport protein Bac_export_2 PF01312.19 PIK38729.1 - 0.84 8.8 3.7 0.64 9.2 0.8 1.9 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family MRP_L53 PF10780.9 PIK38730.1 - 7.2e-14 51.7 0.1 1e-13 51.2 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 SNF2_N PF00176.23 PIK38731.1 - 1.9e-51 174.9 0.0 3.6e-51 173.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK38731.1 - 8.8e-17 61.5 0.0 2.5e-16 60.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK38731.1 - 1.3e-08 35.0 0.0 3.7e-07 30.3 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 PIK38731.1 - 0.0056 15.9 0.0 0.022 13.9 0.0 2.0 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 PIK38731.1 - 0.062 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF2439 PF10382.9 PIK38731.1 - 0.083 13.2 0.3 0.26 11.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) Rubis-subs-bind PF09273.11 PIK38732.1 - 1e-13 52.1 0.8 2.1e-13 51.1 0.8 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 PIK38732.1 - 7.3e-08 33.0 0.0 5.9e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 SET domain DUF2605 PF10792.9 PIK38732.1 - 0.0092 15.9 0.3 0.023 14.6 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2605) SET PF00856.28 PIK38733.1 - 4e-08 33.8 0.0 4.9e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 SET domain DUF624 PF04854.14 PIK38733.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF624 WD40_4 PF16300.5 PIK38734.1 - 1.5e-18 66.4 0.0 2.7e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat Trimer_CC PF08954.11 PIK38734.1 - 2.1 8.0 6.0 3.1 7.4 2.0 2.6 1 1 1 2 2 2 0 Trimerisation motif Lipocalin PF00061.23 PIK38735.1 - 1e-12 48.4 7.5 1.8e-12 47.7 7.5 1.4 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK38735.1 - 2.1e-08 34.2 1.4 2.7e-08 33.8 1.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family YbaB_DNA_bd PF02575.16 PIK38736.1 - 0.068 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 YbaB/EbfC DNA-binding family CS PF04969.16 PIK38737.1 - 2.4e-06 28.5 0.5 5e-06 27.4 0.2 1.7 2 0 0 2 2 2 1 CS domain RT_RNaseH_2 PF17919.1 PIK38738.1 - 9.4e-38 128.3 0.0 2.2e-37 127.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38738.1 - 6.9e-36 122.7 0.0 1.9e-35 121.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38738.1 - 1.9e-15 57.0 0.0 2.7e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK38739.1 - 1.5e-18 66.7 0.1 1.5e-18 66.7 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK38739.1 - 7.5e-17 61.6 0.0 1.8e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 PIK38739.1 - 1.3e-06 28.2 2.0 4.6e-06 26.5 2.0 2.1 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 PIK38739.1 - 0.00016 21.8 0.4 0.00082 19.5 0.0 2.3 2 0 0 2 2 2 1 H2C2 zinc finger zf-CCHC_2 PF13696.6 PIK38739.1 - 0.0031 17.3 1.4 0.0087 15.9 1.4 1.8 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK38739.1 - 0.0064 16.3 0.2 0.036 13.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.6 PIK38739.1 - 0.047 14.3 0.2 6.6 7.4 0.0 3.0 2 1 1 3 3 3 0 gag-polyprotein putative aspartyl protease CitX PF03802.14 PIK38739.1 - 0.087 12.6 1.8 0.25 11.1 0.6 2.3 2 0 0 2 2 2 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase zf-CCHC_5 PF14787.6 PIK38739.1 - 1.4 8.7 7.7 1.2 8.9 2.0 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RT_RNaseH_2 PF17919.1 PIK38740.1 - 2.1e-37 127.2 0.0 4.1e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38740.1 - 1.6e-35 121.6 0.0 3.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK38740.1 - 2.5e-27 95.8 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK38741.1 - 3.2e-17 62.8 0.0 6e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38741.1 - 0.0016 18.5 1.7 0.0031 17.6 1.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK38741.1 - 0.0019 17.9 0.1 0.016 15.0 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK38741.1 - 0.054 13.5 0.2 0.092 12.8 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 Integrase_H2C2 PF17921.1 PIK38742.1 - 7.8e-19 67.5 0.1 2.4e-18 66.0 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK38742.1 - 1.1e-16 61.0 0.0 3.1e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK38742.1 - 4.3e-13 48.9 0.0 1.3e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK38742.1 - 2.8e-06 27.1 2.0 7e-06 25.9 2.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 PIK38742.1 - 0.0012 19.0 2.9 0.0013 18.9 0.0 2.5 3 0 0 3 3 3 1 H2C2 zinc finger zf-CCHC_2 PF13696.6 PIK38742.1 - 0.0064 16.3 1.4 0.013 15.3 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK38742.1 - 0.0096 15.7 0.2 0.063 13.1 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Actin PF00022.19 PIK38743.1 - 1.4e-147 491.6 0.0 4.8e-147 489.8 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 PIK38743.1 - 0.031 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain RRM_1 PF00076.22 PIK38744.1 - 1.5e-20 72.8 0.0 2.2e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 PIK38744.1 - 0.0013 19.4 13.7 0.0021 18.7 13.7 1.3 1 0 0 1 1 1 1 Glycine rich protein family DUF2457 PF10446.9 PIK38744.1 - 0.049 12.8 11.0 0.069 12.3 11.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nup35_RRM_2 PF14605.6 PIK38744.1 - 0.073 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 PIK38744.1 - 0.15 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.11 PIK38744.1 - 1.6 8.8 29.6 7.3 6.7 21.6 3.0 3 0 0 3 3 3 0 Fruit fly transformer protein FAM195 PF14799.6 PIK38745.1 - 2e-08 34.5 0.5 3.1e-08 33.9 0.3 1.4 1 1 0 1 1 1 1 FAM195 family VWC PF00093.18 PIK38746.1 - 0.0003 21.1 9.9 0.0003 21.1 9.9 2.9 3 0 0 3 3 3 1 von Willebrand factor type C domain Sulfatase PF00884.23 PIK38747.1 - 2.6e-65 220.9 0.0 3.1e-65 220.6 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK38747.1 - 4.5e-22 79.1 0.0 9.3e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK38747.1 - 0.0062 16.2 0.1 0.061 12.9 0.1 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PGA2 PF07543.12 PIK38748.1 - 3.3 7.7 9.6 28 4.7 8.8 2.3 2 1 0 2 2 2 0 Protein trafficking PGA2 zf-TRAF PF02176.18 PIK38749.1 - 8.6e-07 29.6 7.2 8.6e-07 29.6 7.2 2.0 2 0 0 2 2 2 1 TRAF-type zinc finger Sina PF03145.16 PIK38749.1 - 0.00012 22.1 8.9 0.0003 20.8 8.5 1.8 1 1 0 1 1 1 1 Seven in absentia protein family DUF4618 PF15397.6 PIK38749.1 - 0.019 14.4 1.4 0.029 13.8 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Hemagglutinin PF00509.18 PIK38749.1 - 0.023 13.1 0.0 0.032 12.6 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin CLZ PF16526.5 PIK38749.1 - 0.029 14.7 0.5 0.081 13.3 0.4 1.7 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DcpS_C PF11969.8 PIK38749.1 - 0.052 14.0 0.1 0.068 13.7 0.1 1.1 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Fungal_TACC PF12709.7 PIK38749.1 - 0.07 13.6 1.4 0.35 11.3 0.8 2.0 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins zf-TRAF_2 PF15965.5 PIK38749.1 - 0.12 12.9 8.2 0.1 13.1 6.1 2.0 1 1 1 2 2 2 0 TRAF-like zinc-finger S4 PF01479.25 PIK38750.1 - 6.1e-11 41.9 2.0 1.9e-10 40.3 2.0 1.9 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 PIK38750.1 - 1.1e-05 26.2 0.9 1.1e-05 26.2 0.9 1.9 2 1 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain EGF PF00008.27 PIK38751.1 - 3.3e-69 228.7 250.7 1.1e-09 38.4 5.0 16.8 16 0 0 16 16 16 14 EGF-like domain hEGF PF12661.7 PIK38751.1 - 1.2e-33 114.6 199.0 5.6e-06 26.8 2.2 18.5 16 1 0 16 16 16 14 Human growth factor-like EGF CUB PF00431.20 PIK38751.1 - 1.5e-18 67.1 0.0 2.5e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 CUB domain EGF_2 PF07974.13 PIK38751.1 - 1.1e-08 35.3 271.7 0.0017 18.6 7.4 15.9 15 1 0 15 15 15 13 EGF-like domain EGF_CA PF07645.15 PIK38751.1 - 0.0038 17.4 22.7 0.0063 16.7 7.0 17.2 8 5 8 16 16 16 7 Calcium-binding EGF domain FixQ PF05545.11 PIK38751.1 - 0.2 11.7 0.0 0.4 10.7 0.0 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Ig_3 PF13927.6 PIK38752.1 - 5e-16 59.1 7.4 1.1e-08 35.5 0.1 4.6 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK38752.1 - 1e-11 45.0 0.6 7.8e-08 32.5 0.0 4.5 5 0 0 5 5 5 1 Immunoglobulin V-set domain ig PF00047.25 PIK38752.1 - 2.1e-11 43.8 3.7 8.2e-06 25.9 0.0 4.4 4 1 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK38752.1 - 7.3e-11 42.2 4.5 0.005 17.1 0.1 4.5 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK38752.1 - 2.5e-09 37.1 0.0 1.9e-05 24.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK38752.1 - 3.9e-06 26.8 0.2 0.00065 19.7 0.1 3.1 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF4722 PF15849.5 PIK38752.1 - 0.0036 17.0 0.6 0.0078 15.9 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4722) LapA_dom PF06305.11 PIK38752.1 - 0.034 14.0 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain UL45 PF05473.12 PIK38752.1 - 0.045 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like EphA2_TM PF14575.6 PIK38752.1 - 0.78 10.7 3.6 4.8 8.1 3.6 2.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Exo84_C PF16528.5 PIK38753.1 - 7e-51 173.0 0.3 2.2e-50 171.3 0.0 2.0 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 PIK38753.1 - 1.3e-15 57.2 1.7 1.3e-15 57.2 1.7 2.7 4 0 0 4 4 4 1 Vps51/Vps67 Dor1 PF04124.12 PIK38753.1 - 8.3e-05 21.4 6.2 0.0038 16.0 0.1 2.6 3 0 0 3 3 3 2 Dor1-like family PH PF00169.29 PIK38753.1 - 0.0029 18.1 0.0 0.006 17.1 0.0 1.6 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 PIK38753.1 - 0.027 14.4 0.3 0.13 12.2 0.1 2.3 1 1 1 2 2 2 0 PH domain CTP_transf_like PF01467.26 PIK38753.1 - 0.11 12.7 0.2 0.34 11.1 0.1 1.9 2 0 0 2 2 2 0 Cytidylyltransferase-like Sec5 PF15469.6 PIK38753.1 - 0.11 12.3 5.5 0.18 11.6 0.0 3.5 4 1 1 5 5 5 0 Exocyst complex component Sec5 LIM PF00412.22 PIK38754.1 - 1.2e-28 99.1 20.1 1.9e-12 47.2 1.6 3.3 3 0 0 3 3 3 3 LIM domain WD40 PF00400.32 PIK38755.1 - 4.6e-14 52.6 10.7 0.00029 21.6 2.3 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 PIK38755.1 - 0.0002 20.8 0.5 0.15 11.3 0.1 2.4 1 1 1 2 2 2 2 WD40-like domain Peptidase_A2E PF12382.8 PIK38755.1 - 0.15 12.1 0.8 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Retrotransposon peptidase Methyltransf_3 PF01596.17 PIK38756.1 - 7.8e-24 84.0 0.0 9.8e-24 83.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 PIK38756.1 - 4.8e-13 50.0 0.0 8.7e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 PIK38756.1 - 1.4e-05 24.9 0.0 2.4e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_31 PF13847.6 PIK38756.1 - 1.9e-05 24.5 0.0 2.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK38756.1 - 4.4e-05 23.3 0.0 0.0005 19.9 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fibrillarin PF01269.17 PIK38756.1 - 0.0018 17.4 0.0 0.0026 16.9 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin Methyltransf_25 PF13649.6 PIK38756.1 - 0.0028 18.3 0.0 0.0063 17.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK38756.1 - 0.0082 15.8 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 PIK38756.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_15 PF09445.10 PIK38756.1 - 0.046 13.3 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase GCD14 PF08704.10 PIK38756.1 - 0.053 13.2 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit P3A PF08727.11 PIK38756.1 - 0.13 11.7 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 Poliovirus 3A protein like Methyltransf_3 PF01596.17 PIK38757.1 - 6.6e-25 87.5 0.0 8e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 PIK38757.1 - 5.9e-14 53.0 0.0 8.5e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 PIK38757.1 - 8.6e-06 25.6 0.0 1.1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_31 PF13847.6 PIK38757.1 - 1.9e-05 24.5 0.0 2.7e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK38757.1 - 0.00015 21.6 0.0 0.00035 20.4 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fibrillarin PF01269.17 PIK38757.1 - 0.00023 20.4 0.0 0.00032 19.9 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 PIK38757.1 - 0.003 17.3 0.0 0.01 15.5 0.0 1.7 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_30 PF05430.11 PIK38757.1 - 0.052 13.4 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MFS_1 PF07690.16 PIK38758.1 - 5.5e-27 94.6 8.6 5.5e-27 94.6 8.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UPF0121 PF03661.13 PIK38758.1 - 0.051 13.0 2.3 0.11 11.9 2.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0121) DCX PF03607.17 PIK38759.1 - 2.7e-30 104.2 0.0 5.1e-15 55.3 0.0 2.8 2 0 0 2 2 2 2 Doublecortin WD40 PF00400.32 PIK38759.1 - 2.7e-20 72.3 12.0 0.011 16.6 0.0 10.5 10 1 0 10 10 10 5 WD domain, G-beta repeat HELP PF03451.14 PIK38759.1 - 2.3e-14 53.0 0.0 6.9e-14 51.5 0.0 1.9 1 0 0 1 1 1 1 HELP motif ANAPC4_WD40 PF12894.7 PIK38759.1 - 1.1e-09 38.5 0.0 4.4e-05 23.7 0.0 4.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK38759.1 - 0.082 12.8 0.2 0.43 10.4 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A CRAL_TRIO_2 PF13716.6 PIK38761.1 - 4.1e-30 104.7 1.8 5.8e-30 104.3 1.8 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain BNIP2 PF12496.8 PIK38761.1 - 1.8e-21 77.0 0.1 2.7e-21 76.4 0.1 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO PF00650.20 PIK38761.1 - 4.1e-06 26.6 0.8 7.3e-06 25.8 0.8 1.4 1 1 0 1 1 1 1 CRAL/TRIO domain DHHA2 PF02833.14 PIK38762.1 - 3e-28 98.8 0.1 5e-28 98.1 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain XRN_M PF17846.1 PIK38762.1 - 0.62 8.9 3.5 0.94 8.4 3.5 1.2 1 0 0 1 1 1 0 Xrn1 helical domain PDDEXK_6 PF04720.12 PIK38762.1 - 1.9 8.4 5.7 7.5 6.4 4.4 2.1 2 0 0 2 2 2 0 PDDEXK-like family of unknown function SAPS PF04499.15 PIK38762.1 - 3.8 6.2 7.9 1.4 7.6 5.4 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Pkinase PF00069.25 PIK38764.1 - 2e-64 217.5 0.0 4e-64 216.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38764.1 - 5.3e-43 147.2 0.0 9e-43 146.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1 PF00415.18 PIK38764.1 - 1.2e-37 128.3 0.4 1.4e-09 38.4 0.0 5.6 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK38764.1 - 6.6e-16 57.7 17.5 2e-06 27.5 1.5 4.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.6 PIK38764.1 - 2.3e-07 30.4 0.0 4.2e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK38764.1 - 0.00038 19.4 0.0 0.00075 18.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF4347 PF14252.6 PIK38764.1 - 0.005 16.7 0.1 0.0092 15.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) Dynactin PF12455.8 PIK38764.1 - 0.057 12.6 0.1 0.13 11.5 0.1 1.5 1 0 0 1 1 1 0 Dynein associated protein RIO1 PF01163.22 PIK38764.1 - 0.072 12.7 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK38764.1 - 0.097 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK38764.1 - 0.14 12.1 0.1 12 5.8 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-nanos PF05741.13 PIK38765.1 - 2.5e-26 91.7 4.0 2.5e-26 91.7 4.0 1.9 2 0 0 2 2 2 1 Nanos RNA binding domain NCD2 PF04905.13 PIK38765.1 - 0.037 14.0 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) zf-ribbon_3 PF13248.6 PIK38765.1 - 0.52 9.8 0.1 0.52 9.8 0.1 3.3 5 0 0 5 5 5 0 zinc-ribbon domain zf-Di19 PF05605.12 PIK38765.1 - 1.2 9.4 6.2 21 5.5 4.7 2.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding WD40 PF00400.32 PIK38766.1 - 1.8e-36 123.5 26.8 2.2e-07 31.5 0.2 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38766.1 - 5e-15 55.6 1.3 6.2e-05 23.2 0.0 6.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK38766.1 - 0.0009 18.3 5.1 0.46 9.4 2.0 3.2 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CorA PF01544.18 PIK38766.1 - 0.0018 17.6 4.4 0.0031 16.9 3.5 1.8 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Cep57_CLD_2 PF14197.6 PIK38766.1 - 0.0037 17.3 8.1 0.081 13.0 2.3 2.9 2 1 0 2 2 2 2 Centrosome localisation domain of PPC89 Nup160 PF11715.8 PIK38766.1 - 0.037 12.7 5.1 3.5 6.2 0.1 4.0 3 1 2 5 5 5 0 Nucleoporin Nup120/160 Fib_alpha PF08702.10 PIK38766.1 - 0.11 12.6 6.9 0.21 11.8 6.9 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 PIK38766.1 - 0.15 10.6 5.3 0.22 10.1 5.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prim-Pol PF09250.11 PIK38766.1 - 0.21 11.9 1.6 2.8 8.3 0.1 2.2 1 1 1 2 2 2 0 Bifunctional DNA primase/polymerase, N-terminal Seryl_tRNA_N PF02403.22 PIK38766.1 - 0.63 10.3 6.1 0.89 9.8 4.4 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.11 PIK38766.1 - 0.87 9.4 8.7 2 8.2 1.5 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 TMF_TATA_bd PF12325.8 PIK38766.1 - 0.93 9.7 8.6 0.54 10.5 4.9 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF745 PF05335.13 PIK38766.1 - 1 9.1 5.2 0.87 9.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CALCOCO1 PF07888.11 PIK38766.1 - 3.2 6.5 14.4 10 4.8 14.2 1.7 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like PHD PF00628.29 PIK38767.1 - 1.1e-21 76.5 21.4 1.6e-12 47.1 5.3 2.7 2 0 0 2 2 2 2 PHD-finger Bromodomain PF00439.25 PIK38767.1 - 1.5e-21 76.3 0.0 3.7e-21 75.0 0.0 1.7 1 0 0 1 1 1 1 Bromodomain WSD PF15613.6 PIK38767.1 - 2.3e-05 24.8 0.4 2.3e-05 24.8 0.4 2.9 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif zf-HC5HC2H_2 PF13832.6 PIK38767.1 - 0.014 15.5 12.7 0.066 13.4 3.8 2.9 1 1 0 2 2 2 0 PHD-zinc-finger like domain C1_1 PF00130.22 PIK38767.1 - 0.019 14.9 6.3 0.019 14.9 6.3 3.0 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.6 PIK38767.1 - 0.02 15.2 14.5 0.37 11.1 4.4 2.9 1 1 1 2 2 2 0 PHD-like zinc-binding domain Zf_RING PF16744.5 PIK38767.1 - 0.3 11.2 12.5 1.1 9.4 1.0 3.0 1 1 1 2 2 2 0 KIAA1045 RING finger PHD_2 PF13831.6 PIK38767.1 - 1.3 8.6 13.2 0.084 12.4 0.6 3.0 3 0 0 3 3 3 0 PHD-finger zf-4CXXC_R1 PF10497.9 PIK38767.1 - 1.8 8.8 16.3 0.035 14.3 7.7 2.6 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Prim_Zn_Ribbon PF08273.12 PIK38767.1 - 1.8 8.9 10.3 6.3 7.2 4.3 3.0 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase MBD PF01429.19 PIK38768.1 - 2.5e-16 59.1 0.0 5.4e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain DDT PF02791.17 PIK38768.1 - 1.1e-06 28.8 0.5 2e-06 28.0 0.5 1.4 1 0 0 1 1 1 1 DDT domain WSD PF15613.6 PIK38768.1 - 2e-06 28.2 8.5 2e-06 28.2 8.5 5.0 3 3 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WHIM1 PF15612.6 PIK38768.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 ATG_C PF09333.11 PIK38769.1 - 2.8e-27 94.9 0.0 1.8e-26 92.3 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 PIK38769.1 - 0.00016 21.5 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal ATG2_CAD PF13329.6 PIK38769.1 - 0.00083 19.1 0.1 0.002 17.9 0.1 1.6 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif Kinesin PF00225.23 PIK38770.1 - 8.1e-109 363.6 0.1 8.1e-109 363.6 0.1 2.5 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK38770.1 - 2.3e-23 82.8 0.1 2.5e-22 79.4 0.0 2.6 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 PIK38770.1 - 0.00027 21.1 0.2 0.00027 21.1 0.2 5.5 3 2 4 7 7 7 2 Kinesin-associated Yop-YscD_cpl PF16697.5 PIK38770.1 - 0.0011 19.2 0.0 0.0058 16.9 0.0 2.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain GAS PF13851.6 PIK38770.1 - 0.022 14.1 0.7 0.022 14.1 0.7 4.3 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding ATP_bind_2 PF03668.15 PIK38771.1 - 0.064 12.5 1.4 0.09 12.1 1.1 1.4 1 1 0 1 1 1 0 P-loop ATPase protein family LpqV PF17301.2 PIK38771.1 - 0.17 12.1 0.5 0.93 9.8 0.1 2.3 1 1 2 3 3 3 0 Putative lipoprotein LpqV Exonuc_VII_L PF02601.15 PIK38771.1 - 0.41 10.2 7.9 0.5 9.9 7.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 PIK38771.1 - 0.41 8.5 4.3 0.49 8.3 4.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 PIK38771.1 - 1.4 7.7 25.7 0.22 10.4 13.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein ORF6C PF10552.9 PIK38771.1 - 3.4 7.8 9.3 0.085 13.0 1.4 2.2 2 1 1 3 3 3 0 ORF6C domain NPV_P10 PF05531.12 PIK38771.1 - 4.2 7.9 6.5 12 6.5 1.5 2.7 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein YkyA PF10368.9 PIK38771.1 - 8.9 5.9 27.2 0.26 11.0 12.9 2.1 1 1 0 2 2 2 0 Putative cell-wall binding lipoprotein PX PF00787.24 PIK38772.1 - 3.1e-18 65.8 0.1 3.1e-18 65.8 0.1 2.4 2 1 0 2 2 2 1 PX domain RPN7 PF10602.9 PIK38772.1 - 0.031 14.0 0.3 0.031 14.0 0.3 2.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 DUF4718 PF15842.5 PIK38772.1 - 0.38 10.5 5.7 0.98 9.2 5.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Flagellin_N PF00669.20 PIK38772.1 - 1.2 9.2 7.3 0.44 10.6 0.8 2.5 1 1 0 2 2 2 0 Bacterial flagellin N-terminal helical region hDGE_amylase PF14701.6 PIK38772.1 - 9.9 5.1 16.0 14 4.7 16.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF445 PF04286.12 PIK38773.1 - 0.0016 18.3 5.1 0.0091 15.8 5.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF445) DnaI_N PF07319.11 PIK38773.1 - 0.063 14.0 4.0 6.4 7.5 0.1 3.4 2 2 1 3 3 3 0 Primosomal protein DnaI N-terminus THOC2_N PF16134.5 PIK38773.1 - 0.36 9.4 4.9 0.37 9.4 3.6 1.5 1 1 0 1 1 1 0 THO complex subunit 2 N-terminus DUF1160 PF06648.11 PIK38773.1 - 0.42 10.6 3.6 0.6 10.1 2.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1160) Neur_chan_LBD PF02931.23 PIK38774.1 - 3.9e-21 75.5 0.5 4.8e-21 75.2 0.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK38774.1 - 1e-09 38.8 0.8 1.7e-09 38.1 0.8 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF4923 PF16270.5 PIK38774.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Lipocalin-like domain (DUF4923) Neur_chan_LBD PF02931.23 PIK38775.1 - 3.9e-48 163.7 3.4 3.9e-48 163.7 3.4 1.4 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK38775.1 - 2.1e-26 93.5 0.0 3.7e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2207 PF09972.9 PIK38775.1 - 0.15 10.8 1.2 1.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4200 PF13863.6 PIK38776.1 - 2e-24 86.2 37.2 8e-24 84.3 26.4 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) DUF5329 PF17263.2 PIK38776.1 - 0.045 13.9 1.4 0.1 12.8 1.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5329) BLOC1_2 PF10046.9 PIK38776.1 - 0.084 13.2 21.8 0.74 10.2 5.4 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.6 PIK38776.1 - 0.17 11.2 31.9 3.6 6.9 19.9 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 PIK38776.1 - 0.24 11.4 28.5 0.45 10.5 16.9 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 PIK38776.1 - 0.58 10.2 19.7 0.71 9.9 2.9 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) TraF_2 PF13729.6 PIK38776.1 - 1.5 8.1 5.7 4.3 6.6 0.3 2.2 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein Spc7 PF08317.11 PIK38776.1 - 1.9 7.3 33.9 0.55 9.0 6.8 2.2 1 1 0 2 2 2 0 Spc7 kinetochore protein TACC_C PF05010.14 PIK38776.1 - 2.5 7.8 31.4 0.3 10.8 17.6 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4407 PF14362.6 PIK38776.1 - 5.1 6.4 18.1 47 3.2 18.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 PIK38776.1 - 5.4 7.1 30.5 4.1 7.5 11.1 3.3 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein WW PF00397.26 PIK38777.1 - 4.9e-14 52.1 5.4 2.4e-08 33.9 2.6 2.5 2 0 0 2 2 2 2 WW domain Radial_spoke PF04712.12 PIK38778.1 - 2.9e-204 679.6 13.7 2.9e-204 679.6 13.7 1.7 1 1 1 2 2 2 1 Radial spokehead-like protein CPSF100_C PF13299.6 PIK38778.1 - 0.24 11.6 0.1 0.24 11.6 0.1 3.1 3 1 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Na_trans_assoc PF06512.13 PIK38778.1 - 9.7 6.4 24.3 5.8 7.1 5.4 2.9 2 1 0 2 2 2 0 Sodium ion transport-associated DEAD PF00270.29 PIK38779.1 - 8.3e-45 152.7 0.4 1.6e-44 151.7 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK38779.1 - 2.9e-33 114.5 0.1 3.4e-32 111.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 PIK38779.1 - 1.3e-05 25.6 0.1 0.00032 21.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK38779.1 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK38779.1 - 0.0019 18.2 0.0 0.0053 16.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 PIK38779.1 - 0.0022 16.9 0.1 0.31 9.8 0.0 2.4 3 0 0 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 PIK38779.1 - 0.015 15.6 0.2 0.083 13.2 0.2 2.0 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 PIK38779.1 - 0.038 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Helicase Fanconi_A PF03511.14 PIK38779.1 - 0.04 13.8 0.2 0.66 9.9 0.1 2.3 2 0 0 2 2 2 0 Fanconi anaemia group A protein TniB PF05621.11 PIK38779.1 - 0.1 12.0 0.0 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein tRNA-synt_1b PF00579.25 PIK38779.1 - 0.13 11.6 0.0 0.33 10.2 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) UvrD-helicase PF00580.21 PIK38779.1 - 0.2 11.1 0.2 0.44 10.0 0.2 1.3 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Pkinase_Tyr PF07714.17 PIK38780.1 - 4.7e-85 285.0 0.0 7.1e-85 284.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK38780.1 - 5.9e-35 120.9 0.0 1.1e-34 120.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK38780.1 - 2.4e-34 117.5 12.1 6.4e-11 42.4 1.7 4.8 3 1 1 4 4 4 4 Fibronectin type III domain I-set PF07679.16 PIK38780.1 - 2.5e-10 40.3 1.1 0.00053 20.0 0.1 2.9 3 0 0 3 3 2 2 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 PIK38780.1 - 2e-09 37.9 5.3 0.011 16.3 1.2 4.8 2 1 2 4 4 4 2 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 PIK38780.1 - 2.7e-09 37.5 1.1 0.0008 20.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK38780.1 - 1.2e-06 28.6 0.0 0.064 13.4 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain EGF_2 PF07974.13 PIK38780.1 - 0.00037 20.8 57.9 0.001 19.4 11.6 4.6 4 0 0 4 4 4 2 EGF-like domain Pkinase_fungal PF17667.1 PIK38780.1 - 0.0015 17.4 0.0 0.0024 16.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Ig_2 PF13895.6 PIK38780.1 - 0.0031 17.8 0.0 4.7 7.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain hEGF PF12661.7 PIK38780.1 - 0.0038 17.8 7.2 0.0038 17.8 7.2 4.3 3 0 0 3 3 3 1 Human growth factor-like EGF Kinase-like PF14531.6 PIK38780.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like EGF PF00008.27 PIK38780.1 - 2.5 8.5 49.1 0.078 13.3 11.3 4.3 4 0 0 4 4 4 0 EGF-like domain Laminin_EGF PF00053.24 PIK38780.1 - 9.8 6.4 48.5 4.4 7.5 4.8 4.0 2 1 2 4 4 4 0 Laminin EGF domain PGM_PMM_IV PF00408.20 PIK38781.1 - 4e-05 23.7 0.0 5.2e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Flag1_repress PF03614.13 PIK38781.1 - 0.032 14.0 0.1 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 Repressor of phase-1 flagellin PGM_PMM_I PF02878.16 PIK38782.1 - 4e-34 117.3 0.3 6.1e-34 116.7 0.3 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 PIK38782.1 - 2.6e-15 56.9 0.2 5.1e-15 56.0 0.2 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 PIK38782.1 - 0.005 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III IL17 PF06083.11 PIK38783.1 - 7.2e-22 77.7 1.3 2e-21 76.2 1.3 1.7 1 0 0 1 1 1 1 Interleukin-17 FMN_dh PF01070.18 PIK38784.1 - 2.1e-93 313.2 0.0 2.5e-93 312.9 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK38784.1 - 1.7e-07 30.6 0.0 2.3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK38784.1 - 9.9e-06 24.9 0.0 1.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 PIK38784.1 - 0.001 18.6 0.1 0.0023 17.4 0.1 1.6 1 1 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 PIK38784.1 - 0.0031 16.9 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 PIK38784.1 - 0.055 12.8 0.2 1 8.6 0.1 2.1 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Yos1 PF08571.10 PIK38785.1 - 0.028 14.7 3.8 0.028 14.7 0.8 2.3 1 1 1 2 2 2 0 Yos1-like Gram_pos_anchor PF00746.21 PIK38785.1 - 0.077 13.0 0.1 0.28 11.2 0.1 1.9 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF4653 PF15546.6 PIK38786.1 - 0.12 12.0 2.6 0.14 11.8 2.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) TPD PF14811.6 PIK38787.1 - 4.6e-32 110.7 1.2 1.8e-30 105.6 1.2 2.4 1 1 0 1 1 1 1 Protein of unknown function TPD sequence-motif Init_tRNA_PT PF04179.12 PIK38787.1 - 0.082 13.2 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain F-box PF00646.33 PIK38789.1 - 5.4e-05 23.0 0.6 0.0001 22.1 0.6 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK38789.1 - 0.0023 17.8 0.2 0.0052 16.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like FAM76 PF16046.5 PIK38789.1 - 0.0038 16.6 4.0 0.0038 16.6 4.0 2.1 2 0 0 2 2 2 1 FAM76 protein F-box_4 PF15966.5 PIK38789.1 - 0.0085 16.0 0.4 0.022 14.6 0.4 1.7 1 0 0 1 1 1 1 F-box HAP1_N PF04849.13 PIK38789.1 - 0.01 15.1 5.8 0.01 15.1 5.8 1.8 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Taxilin PF09728.9 PIK38789.1 - 0.011 14.9 9.0 0.073 12.2 8.6 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein ATG16 PF08614.11 PIK38789.1 - 0.033 14.4 7.1 0.1 12.8 7.1 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) BRE1 PF08647.11 PIK38789.1 - 0.087 12.9 7.6 0.3 11.2 7.6 1.9 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase FH2 PF02181.23 PIK38789.1 - 0.093 11.8 8.5 0.04 13.1 5.2 1.9 2 0 0 2 2 2 0 Formin Homology 2 Domain USP8_interact PF08941.10 PIK38789.1 - 0.37 10.6 8.9 0.59 9.9 4.1 2.4 1 1 1 2 2 2 0 USP8 interacting TMF_DNA_bd PF12329.8 PIK38789.1 - 0.79 9.8 14.8 5.3 7.1 9.9 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 PIK38789.1 - 0.92 10.2 13.5 0.064 13.9 5.2 3.0 2 1 1 3 3 3 0 SlyX TMPIT PF07851.13 PIK38789.1 - 1.2 8.3 4.6 2.5 7.3 4.6 1.4 1 0 0 1 1 1 0 TMPIT-like protein Fib_alpha PF08702.10 PIK38789.1 - 1.7 8.8 10.7 5.5 7.2 5.7 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 PIK38789.1 - 3.1 7.8 13.8 0.18 11.8 7.9 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-H2C2_2 PF13465.6 PIK38790.1 - 1.3e-17 63.3 78.9 7.2e-05 23.0 1.8 12.0 11 1 1 12 12 12 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK38790.1 - 1.8e-17 62.5 83.2 0.043 14.7 1.7 12.0 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK38790.1 - 4.3e-16 58.4 83.7 0.0053 17.1 0.5 12.3 12 0 0 12 12 12 8 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 PIK38790.1 - 0.001 19.0 0.2 0.001 19.0 0.2 12.0 12 0 0 12 12 12 5 C2H2-type zinc finger VCX_VCY PF15231.6 PIK38790.1 - 0.077 13.7 0.1 2.8 8.6 0.0 2.6 2 0 0 2 2 2 0 Variable charge X/Y family zinc_ribbon_9 PF14369.6 PIK38790.1 - 5.3 7.4 21.7 4.7 7.6 0.0 5.8 7 0 0 7 7 7 0 zinc-ribbon zf-C2H2_3rep PF18868.1 PIK38790.1 - 9.6 6.9 35.9 0.39 11.4 0.2 6.1 2 1 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats TPR_2 PF07719.17 PIK38791.1 - 8.7e-09 34.8 9.2 4.8e-06 26.3 0.1 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK38791.1 - 5.7e-06 26.7 0.1 5.7e-05 23.5 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK38791.1 - 6.3e-06 26.3 1.5 0.00026 21.2 0.1 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 PIK38791.1 - 1.3e-05 24.7 18.2 0.00016 21.3 0.6 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK38791.1 - 0.00062 20.0 1.7 0.021 15.2 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK38791.1 - 0.00072 20.2 0.1 0.0082 16.8 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK38791.1 - 0.00099 19.4 5.1 0.49 10.7 0.2 3.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK38791.1 - 0.022 15.0 7.5 0.026 14.7 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK38791.1 - 0.043 14.6 0.1 2 9.4 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 PIK38791.1 - 0.086 12.9 3.6 0.12 12.4 0.2 2.2 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_6 PF13174.6 PIK38791.1 - 0.095 13.4 0.9 0.68 10.7 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4398 PF14346.6 PIK38791.1 - 0.11 13.1 0.5 3.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) SPO22 PF08631.10 PIK38791.1 - 0.11 12.0 2.1 0.42 10.0 0.3 2.4 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_11 PF13414.6 PIK38791.1 - 0.36 10.5 11.4 2.7 7.7 0.1 4.1 3 1 2 5 5 5 0 TPR repeat Sprouty PF05210.13 PIK38792.1 - 5.8e-29 100.5 19.3 1e-28 99.7 19.3 1.4 1 0 0 1 1 1 1 Sprouty protein (Spry) WH1 PF00568.23 PIK38792.1 - 6.4e-07 29.3 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 WH1 domain FAINT PF04385.15 PIK38793.1 - 0.082 13.0 0.2 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function, DUF529 Exo_endo_phos_2 PF14529.6 PIK38793.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Apolipoprotein PF01442.18 PIK38794.1 - 1.5e-05 24.9 16.8 0.00039 20.3 2.7 3.7 1 1 2 3 3 3 3 Apolipoprotein A1/A4/E domain AhpC-TSA_2 PF13911.6 PIK38795.1 - 1e-16 61.0 0.0 1.4e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 PIK38795.1 - 1.6e-08 34.5 0.0 2.2e-08 34.1 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK38795.1 - 0.12 12.1 0.0 0.41 10.3 0.0 1.7 2 0 0 2 2 2 0 Redoxin Alpha_TIF PF02232.15 PIK38796.1 - 0.092 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Alpha trans-inducing protein (Alpha-TIF) Importin_rep_4 PF18808.1 PIK38797.1 - 2.4 8.5 8.5 17 5.8 0.1 3.3 3 0 0 3 3 3 0 Importin repeat BAR_3 PF16746.5 PIK38798.1 - 0.083 12.6 0.9 0.22 11.2 0.6 1.8 2 0 0 2 2 2 0 BAR domain of APPL family Phage_int_SAM_4 PF13495.6 PIK38800.1 - 2.8e-06 27.7 0.0 6.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK38800.1 - 0.0007 19.8 0.2 0.0026 18.0 0.2 2.1 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 PIK38802.1 - 8.9e-16 58.1 0.0 1.7e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ac110_PIF PF07280.11 PIK38803.1 - 0.00033 20.4 0.6 5.3e+02 0.5 0.0 7.8 9 0 0 9 9 9 0 Per os infectivity factor AC110 zf-CCHC PF00098.23 PIK38805.1 - 1.6e-07 31.1 15.8 0.00046 20.1 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK38805.1 - 0.01 15.7 13.3 0.07 13.0 3.8 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK38805.1 - 0.012 15.3 11.1 3.5 7.4 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK38805.1 - 0.015 15.3 16.0 0.18 11.8 1.3 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK38805.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK38805.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger U3snoRNP10 PF12397.8 PIK38806.1 - 0.046 14.1 0.3 0.098 13.0 0.2 1.7 1 1 0 1 1 1 0 U3 small nucleolar RNA-associated protein 10 Glyco_hydro_129 PF11308.8 PIK38806.1 - 0.071 12.3 0.2 0.12 11.5 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases related to GH101 family, GH129 Zn_ribbon_recom PF13408.6 PIK38806.1 - 0.24 12.0 2.9 0.55 10.8 1.0 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-CCHC_4 PF14392.6 PIK38807.1 - 1.1 9.1 3.7 8.7 6.2 0.6 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK38807.1 - 1.4 9.0 8.8 0.68 9.9 0.8 2.8 3 0 0 3 3 3 0 Zinc knuckle DUF1922 PF09082.10 PIK38808.1 - 0.00019 21.6 3.6 8.1 6.8 0.1 3.9 1 1 4 5 5 5 4 Domain of unknown function (DUF1922) RET_CLD4 PF17813.1 PIK38808.1 - 0.0002 21.6 0.1 55 4.1 0.0 4.7 1 1 6 7 7 7 0 RET Cadherin like domain 4 CRISPR_assoc PF08798.11 PIK38808.1 - 0.016 15.3 0.0 89 3.1 0.0 3.4 1 1 5 6 6 6 0 CRISPR associated protein GMC_oxred_C PF05199.13 PIK38808.1 - 0.17 12.4 6.1 17 5.9 0.0 5.5 1 1 6 7 7 7 0 GMC oxidoreductase RVT_1 PF00078.27 PIK38810.1 - 1.3e-34 119.7 0.0 1.5e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK38810.1 - 0.056 13.5 0.0 0.074 13.1 0.0 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Keratin_2_head PF16208.5 PIK38811.1 - 0.0032 17.6 3.2 0.0044 17.2 3.2 1.2 1 0 0 1 1 1 1 Keratin type II head KDZ PF18758.1 PIK38812.1 - 1.8e-15 57.1 0.0 2.3e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase HYR PF02494.16 PIK38813.1 - 7.3e-25 87.1 5.7 1.3e-16 60.7 2.2 2.8 2 0 0 2 2 2 2 HYR domain Sushi PF00084.20 PIK38813.1 - 2.7e-22 79.1 30.4 1.9e-11 44.3 8.2 3.6 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) DUF5011 PF16403.5 PIK38813.1 - 0.12 12.5 0.2 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Lipocalin_7 PF14651.6 PIK38814.1 - 1.9e-09 37.5 0.1 2.3e-09 37.2 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK38815.1 - 0.019 14.9 0.0 0.025 14.5 0.0 1.1 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Carn_acyltransf PF00755.20 PIK38816.1 - 1.8e-187 624.6 0.0 2e-187 624.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Pro_dh-DNA_bdg PF14850.6 PIK38816.1 - 0.064 13.8 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 DNA-binding domain of Proline dehydrogenase Sushi PF00084.20 PIK38817.1 - 1e-10 42.0 7.4 3.3e-08 34.0 0.1 2.5 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) IGFL PF14653.6 PIK38817.1 - 0.011 15.6 0.6 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 Insulin growth factor-like family adh_short PF00106.25 PIK38818.1 - 2.2e-33 115.3 0.1 5.6e-33 114.1 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38818.1 - 2.3e-24 86.3 0.0 5.5e-24 85.0 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38818.1 - 8.7e-07 29.0 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 KR domain LptE PF04390.12 PIK38818.1 - 0.029 15.1 0.0 0.066 13.9 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide-assembly NAD_binding_10 PF13460.6 PIK38818.1 - 0.036 14.0 0.2 0.11 12.4 0.2 1.7 1 1 0 1 1 1 0 NAD(P)H-binding AIM5 PF17050.5 PIK38819.1 - 0.16 12.8 1.9 2.1 9.2 0.2 2.6 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 Glyco_transf_8 PF01501.20 PIK38820.1 - 1.5e-12 47.7 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 PIK38820.1 - 0.12 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase QRPTase_C PF01729.19 PIK38821.1 - 2e-23 83.0 0.0 2.3e-23 82.8 0.0 1.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Pantoate_transf PF02548.15 PIK38821.1 - 0.017 14.5 0.3 0.022 14.1 0.3 1.1 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase CLASP_N PF12348.8 PIK38822.1 - 1.7e-28 99.7 7.9 1.1e-06 28.4 0.0 6.2 5 1 0 5 5 5 5 CLASP N terminal HEAT PF02985.22 PIK38822.1 - 6.5e-19 66.4 7.9 0.027 14.7 0.0 10.1 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.6 PIK38822.1 - 1.5e-14 54.2 2.1 0.024 15.0 0.0 8.3 7 1 1 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 PIK38822.1 - 2e-10 40.9 7.1 0.004 17.6 0.1 7.5 7 1 1 8 8 8 2 HEAT-like repeat Cnd1 PF12717.7 PIK38822.1 - 2.7e-07 30.8 10.9 0.87 9.6 0.3 8.3 7 2 0 8 8 8 2 non-SMC mitotic condensation complex subunit 1 TAN PF11640.8 PIK38822.1 - 0.00013 22.1 4.8 13 5.9 0.0 5.8 5 0 0 5 5 5 2 Telomere-length maintenance and DNA damage repair RTP1_C1 PF10363.9 PIK38822.1 - 0.00058 20.0 6.7 1.4 9.1 0.1 5.9 6 0 0 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 PIK38822.1 - 0.0032 17.1 2.2 13 5.3 0.0 5.6 3 3 1 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II Herpes_MCP PF03122.14 PIK38822.1 - 0.0032 15.0 0.2 0.0049 14.4 0.2 1.1 1 0 0 1 1 1 1 Herpes virus major capsid protein Vac14_Fab1_bd PF12755.7 PIK38822.1 - 0.0045 17.6 3.5 1.3e+02 3.2 0.0 7.0 9 0 0 9 9 8 0 Vacuolar 14 Fab1-binding region Nipped-B_C PF12830.7 PIK38822.1 - 0.23 11.4 2.8 9.2 6.2 0.0 3.9 4 1 0 4 4 4 0 Sister chromatid cohesion C-terminus Aminotran_4 PF01063.19 PIK38823.1 - 6.9e-29 101.3 0.0 8.7e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV L27 PF02828.16 PIK38824.1 - 8.6e-20 70.3 0.1 1.4e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 L27 domain PDZ PF00595.24 PIK38824.1 - 1.4e-13 51.0 0.1 2.3e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK38824.1 - 5.2e-07 29.4 0.3 1.5e-06 27.9 0.1 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK38824.1 - 0.022 15.1 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 PDZ domain RVT_1 PF00078.27 PIK38825.1 - 4.4e-05 23.1 0.0 6.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipocalin_7 PF14651.6 PIK38828.1 - 1.8e-07 31.1 0.3 2e-07 31.0 0.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK38829.1 - 6.2e-07 29.4 0.2 7.9e-07 29.1 0.2 1.2 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 PIK38832.1 - 4.2e-09 36.8 0.7 4.7e-09 36.6 0.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK38832.1 - 7e-05 22.8 0.9 9.3e-05 22.4 0.9 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family RE_MjaI PF09568.10 PIK38832.1 - 0.08 12.8 0.1 12 5.7 0.0 2.1 2 0 0 2 2 2 0 MjaI restriction endonuclease Phage_int_SAM_4 PF13495.6 PIK38834.1 - 0.039 14.4 0.0 0.083 13.4 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK38834.1 - 0.076 13.3 0.1 0.2 12.0 0.1 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Brix PF04427.18 PIK38835.1 - 8e-44 150.1 0.6 1.6e-43 149.0 0.6 1.5 1 0 0 1 1 1 1 Brix domain Collagen PF01391.18 PIK38835.1 - 0.00037 20.2 15.0 0.0011 18.6 15.0 1.9 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DUF5308 PF17233.2 PIK38835.1 - 0.02 15.1 0.6 0.035 14.3 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5308) PBP_sp32 PF07222.12 PIK38835.1 - 0.027 13.9 10.9 0.039 13.4 10.9 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PPL5 PF18168.1 PIK38835.1 - 0.17 11.1 3.6 0.29 10.4 3.6 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF4746 PF15928.5 PIK38835.1 - 1.3 8.4 8.0 2 7.8 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EMC3_TMCO1 PF01956.16 PIK38835.1 - 2 8.1 5.6 4 7.1 5.6 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Presenilin PF01080.17 PIK38835.1 - 5.5 5.6 6.8 8.1 5.1 6.8 1.2 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 PIK38835.1 - 6.8 5.0 9.0 10 4.4 9.0 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Coq4 PF05019.13 PIK38836.1 - 2.2e-72 243.0 0.1 2.5e-72 242.8 0.1 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Sen15 PF09631.10 PIK38837.1 - 4.5e-26 91.1 0.2 5.8e-26 90.7 0.2 1.1 1 0 0 1 1 1 1 Sen15 protein Alpha-amylase PF00128.24 PIK38838.1 - 4.1e-88 296.2 0.2 4.1e-88 296.2 0.2 1.5 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Sec1 PF00995.23 PIK38839.1 - 5.8e-17 62.1 5.9 6.6e-11 42.1 2.9 2.0 2 0 0 2 2 2 2 Sec1 family zf-UBR PF02207.20 PIK38840.1 - 7.7e-08 32.4 14.3 2.2e-07 31.0 14.3 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) VIR_N PF15912.5 PIK38840.1 - 5.9 6.4 7.7 2.3 7.7 4.2 2.0 2 0 0 2 2 2 0 Virilizer, N-terminal DHODB_Fe-S_bind PF10418.9 PIK38840.1 - 9.6 6.1 9.0 76 3.2 8.2 2.5 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B E3_UbLigase_R4 PF13764.6 PIK38841.1 - 3.5e-125 419.1 5.0 3.5e-125 419.1 5.0 2.5 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase UBR4 DUF1512 PF07431.12 PIK38841.1 - 0.035 13.1 0.1 0.1 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) UIM PF02809.20 PIK38841.1 - 0.068 13.1 6.6 0.21 11.6 6.6 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif UPF0547 PF10571.9 PIK38841.1 - 0.34 11.1 6.8 1.4 9.1 6.8 2.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.12 PIK38841.1 - 2.3 8.2 8.8 11 6.1 8.8 2.2 1 0 0 1 1 1 0 zinc-ribbons E3_UbLigase_R4 PF13764.6 PIK38842.1 - 2.5e-159 532.1 0.7 4.8e-89 299.6 1.0 2.0 1 1 1 2 2 2 2 E3 ubiquitin-protein ligase UBR4 Paramyxo_ncap PF00973.19 PIK38842.1 - 0.011 14.6 0.2 0.016 14.1 0.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4929 PF16283.5 PIK38842.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) Cg6151-P PF10233.9 PIK38843.1 - 1.3e-16 60.9 11.9 1.6e-16 60.6 11.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P COPI_assoc PF08507.10 PIK38843.1 - 8.8e-05 22.6 5.3 0.00011 22.3 5.3 1.2 1 0 0 1 1 1 1 COPI associated protein SUR7 PF06687.12 PIK38843.1 - 0.0028 17.3 2.0 0.036 13.7 0.2 2.1 2 0 0 2 2 2 2 SUR7/PalI family Fibrinogen_C PF00147.18 PIK38844.1 - 2.3e-77 259.7 14.9 4.4e-43 147.6 10.8 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38845.1 - 3.3e-34 118.6 0.2 3.4e-34 118.6 0.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38846.1 - 8e-86 287.4 9.4 5.5e-57 193.1 10.2 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38846.1 - 3.8e-07 30.3 17.4 3.8e-07 30.3 17.4 3.4 2 1 1 3 3 3 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK38846.1 - 8.8e-05 22.4 3.5 8.8e-05 22.4 3.5 2.9 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK38846.1 - 0.0025 18.0 9.3 0.0025 18.0 9.3 3.2 3 0 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK38847.1 - 9.9e-51 172.6 1.8 1.1e-39 136.6 0.3 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38847.1 - 8.1e-05 22.5 4.5 8.1e-05 22.5 4.5 3.5 2 1 0 3 3 3 1 TILa domain COLFI PF01410.18 PIK38847.1 - 0.00019 20.8 2.5 0.0043 16.4 0.6 2.3 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain EGF_3 PF12947.7 PIK38847.1 - 0.00065 19.8 7.1 0.00065 19.8 7.1 3.8 5 0 0 5 5 5 1 EGF domain Fibrinogen_C PF00147.18 PIK38848.1 - 4.8e-35 121.4 0.0 5.8e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38848.1 - 4.4e-08 33.2 17.8 7.2e-08 32.6 17.8 1.3 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Calcyon PF06387.11 PIK38848.1 - 0.21 11.5 0.4 0.32 11.0 0.4 1.2 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Fibrinogen_C PF00147.18 PIK38849.1 - 9.8e-72 241.3 14.5 4e-39 134.7 0.1 3.2 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38849.1 - 2.6e-07 30.8 17.3 2.6e-07 30.8 17.3 3.6 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38849.1 - 0.0004 20.5 5.8 0.0004 20.5 5.8 3.4 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK38849.1 - 0.00043 20.2 4.1 0.00043 20.2 4.1 3.7 4 1 0 4 4 4 1 TILa domain COLFI PF01410.18 PIK38849.1 - 0.00054 19.3 1.7 0.0095 15.3 0.3 2.3 2 0 0 2 2 2 1 Fibrillar collagen C-terminal domain SRCR PF00530.18 PIK38850.1 - 1.5e-19 70.3 0.1 1.5e-19 70.3 0.1 1.8 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain WSC PF01822.19 PIK38850.1 - 7.2e-08 32.5 2.0 2e-07 31.1 1.0 2.2 2 0 0 2 2 2 1 WSC domain Sushi PF00084.20 PIK38850.1 - 8.5e-07 29.5 0.4 8.5e-07 29.5 0.4 2.7 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) SRCR_2 PF15494.6 PIK38850.1 - 0.00043 20.8 0.0 0.0013 19.3 0.0 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Insulin_TMD PF17870.1 PIK38850.1 - 0.005 16.9 2.5 0.005 16.9 2.5 1.7 2 0 0 2 2 2 1 Insulin receptor trans-membrane segment TMEM154 PF15102.6 PIK38850.1 - 0.022 14.7 2.0 0.032 14.1 0.2 2.2 1 1 1 2 2 2 0 TMEM154 protein family Use1 PF09753.9 PIK38850.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF5383 PF17355.2 PIK38850.1 - 0.15 12.5 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5383) TMEM72 PF16054.5 PIK38850.1 - 0.36 10.5 7.3 1 9.0 0.1 3.5 4 0 0 4 4 4 0 Transmembrane protein family 72 Fibrinogen_C PF00147.18 PIK38851.1 - 2.3e-42 145.3 4.5 3.4e-42 144.7 4.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK38851.1 - 1.3e-07 31.7 14.8 3.7e-07 30.2 7.5 2.5 2 0 0 2 2 2 2 EGF domain TILa PF12714.7 PIK38851.1 - 0.00052 19.9 3.9 0.00052 19.9 3.9 1.7 2 0 0 2 2 2 1 TILa domain EGF_2 PF07974.13 PIK38851.1 - 0.049 14.0 6.5 0.049 14.0 6.5 2.5 2 0 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK38851.1 - 0.063 13.3 3.8 0.18 11.9 3.8 1.8 1 0 0 1 1 1 0 MSP1 EGF domain 1 EGF_CA PF07645.15 PIK38851.1 - 0.88 9.8 16.7 0.37 11.0 7.3 2.6 1 1 1 2 2 2 0 Calcium-binding EGF domain FMO-like PF00743.19 PIK38852.1 - 2.5e-125 418.9 0.0 3e-125 418.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK38852.1 - 4.8e-13 49.0 0.3 4.5e-11 42.6 0.3 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK38852.1 - 2.7e-10 39.9 0.1 3.4e-07 29.8 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 PIK38852.1 - 3.8e-09 36.2 0.0 9.1e-09 35.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK38852.1 - 3.5e-05 23.9 0.7 0.00036 20.7 0.0 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 PIK38852.1 - 0.0042 17.6 0.1 2.8 8.6 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK38852.1 - 0.005 16.1 0.6 0.37 10.0 0.0 2.3 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 PIK38852.1 - 0.012 15.6 0.1 0.25 11.3 0.0 3.2 4 1 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 PIK38852.1 - 0.067 12.3 0.0 5.4 6.0 0.1 3.1 3 1 1 4 4 4 0 FAD binding domain DAO PF01266.24 PIK38852.1 - 0.076 12.6 0.0 10 5.6 0.0 3.4 4 0 0 4 4 4 0 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK38852.1 - 0.16 10.6 0.1 0.49 9.0 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 PIK38852.1 - 0.26 10.6 0.2 1 8.6 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase NHL PF01436.21 PIK38853.1 - 0.53 10.4 3.4 67 3.8 0.0 4.0 5 0 0 5 5 5 0 NHL repeat zf-B_box PF00643.24 PIK38854.1 - 0.0012 19.0 7.6 0.0012 19.0 7.6 1.9 2 0 0 2 2 2 1 B-box zinc finger Apolipoprotein PF01442.18 PIK38854.1 - 0.0024 17.8 10.0 0.0059 16.5 10.0 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain ALMT PF11744.8 PIK38854.1 - 0.084 11.7 7.3 0.11 11.3 7.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter YtxH PF12732.7 PIK38854.1 - 0.35 11.5 8.5 0.92 10.1 2.1 2.9 2 1 0 2 2 2 0 YtxH-like protein AAA_11 PF13086.6 PIK38854.1 - 2.3 7.9 8.8 3.5 7.3 8.8 1.3 1 0 0 1 1 1 0 AAA domain Ldt_C PF17969.1 PIK38854.1 - 4 8.2 7.2 15 6.4 0.4 3.2 3 0 0 3 3 3 0 L,D-transpeptidase C-terminal domain SRCR PF00530.18 PIK38856.1 - 7.1e-31 106.7 1.3 8e-31 106.5 1.3 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK38856.1 - 4.2e-06 27.2 0.1 6.8e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain LRR_4 PF12799.7 PIK38857.1 - 0.023 15.1 1.9 0.023 15.1 1.9 2.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK38857.1 - 2.6 8.3 7.5 2.4 8.4 0.2 3.3 3 0 0 3 3 3 0 Leucine Rich repeat COX16 PF14138.6 PIK38857.1 - 4.4 7.9 0.0 4.4 7.9 0.0 4.5 5 1 0 5 5 5 0 Cytochrome c oxidase assembly protein COX16 DUF4590 PF15257.6 PIK38858.1 - 4.3e-47 158.7 0.5 8.4e-47 157.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4590) FAM198 PF15051.6 PIK38859.1 - 5.7e-60 202.9 0.7 9.1e-60 202.2 0.7 1.3 1 0 0 1 1 1 1 FAM198 protein DUF725 PF05267.12 PIK38859.1 - 0.4 10.7 0.1 0.4 10.7 0.1 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF725) Sec6 PF06046.13 PIK38860.1 - 8.2e-80 268.8 12.4 6.9e-61 206.3 3.4 2.2 2 0 0 2 2 2 2 Exocyst complex component Sec6 Exo84_C PF16528.5 PIK38860.1 - 0.007 16.2 2.5 0.027 14.3 0.0 3.1 2 1 0 3 3 3 1 Exocyst component 84 C-terminal Tk-SP_N-pro PF18237.1 PIK38860.1 - 0.49 10.5 2.2 0.41 10.7 0.2 2.0 2 0 0 2 2 2 0 Tk-SP N-propeptide domain THOC7 PF05615.13 PIK38860.1 - 1.7 8.9 7.5 1.1 9.5 2.5 2.6 2 0 0 2 2 2 0 Tho complex subunit 7 zf-C2HE PF16278.5 PIK38861.1 - 2e-07 31.4 8.7 8.8e-05 22.9 0.4 3.5 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 PIK38861.1 - 8.2e-07 29.3 19.4 0.011 16.5 1.9 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK38861.1 - 3.5e-06 26.7 11.6 0.0002 21.0 0.9 3.5 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2 PF00096.26 PIK38861.1 - 3.2e-05 24.1 21.2 0.02 15.3 2.7 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 PIK38861.1 - 3.3e-05 24.2 9.0 0.21 11.9 0.6 3.2 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 PIK38861.1 - 4.2e-05 23.5 13.5 0.019 14.9 0.3 3.5 3 0 0 3 3 3 2 BED zinc finger zf-H2C2_2 PF13465.6 PIK38861.1 - 0.00048 20.4 20.8 0.0031 17.9 0.7 5.1 4 1 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK38861.1 - 0.0039 17.4 7.1 0.84 10.0 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK38861.1 - 0.006 16.3 10.5 0.047 13.5 1.9 3.6 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 PIK38861.1 - 0.026 14.4 0.5 4.9 7.2 0.0 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger FYVE_2 PF02318.16 PIK38861.1 - 0.029 14.6 1.9 4.1 7.6 0.5 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger BIR PF00653.21 PIK38861.1 - 0.059 14.0 0.7 14 6.5 0.1 2.4 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain SPX PF03105.19 PIK38861.1 - 0.57 10.0 13.6 0.9 9.4 13.6 1.2 1 0 0 1 1 1 0 SPX domain DUF629 PF04780.12 PIK38861.1 - 0.64 8.5 6.9 1.6 7.2 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-met PF12874.7 PIK38861.1 - 0.98 9.9 10.3 1.9 9.0 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 PIK38861.1 - 1.2 8.8 5.7 2.2 8.0 0.1 3.0 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain TFIIF_alpha PF05793.12 PIK38861.1 - 1.6 7.3 19.8 1.8 7.1 19.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 PIK38861.1 - 2.2 6.4 14.8 2.8 6.0 14.8 1.1 1 0 0 1 1 1 0 Nop14-like family Zn-ribbon_8 PF09723.10 PIK38861.1 - 6.6 6.9 6.5 27 5.0 0.1 3.5 4 0 0 4 4 4 0 Zinc ribbon domain Hid1 PF12722.7 PIK38861.1 - 8 4.5 9.1 10 4.1 9.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 PIK38861.1 - 10 4.8 8.7 13 4.4 8.7 1.2 1 0 0 1 1 1 0 Presenilin zf-C2H2 PF00096.26 PIK38862.1 - 0.00034 20.9 1.3 0.00034 20.9 1.3 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 PIK38862.1 - 0.0049 17.2 5.5 0.11 12.9 1.2 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK38862.1 - 0.054 13.8 4.8 0.48 10.8 0.2 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 PIK38862.1 - 0.2 12.2 8.6 0.52 10.8 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK38862.1 - 0.39 11.7 6.9 5.8 8.0 1.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK38862.1 - 4.8 7.3 7.4 5 7.2 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Arm PF00514.23 PIK38863.1 - 5.2e-48 159.7 35.0 1.1e-09 38.0 0.0 10.9 10 1 0 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK38863.1 - 1.2e-17 64.0 18.0 2.6e-05 24.6 0.2 8.3 6 2 2 8 8 8 4 HEAT-like repeat HEAT_2 PF13646.6 PIK38863.1 - 9.6e-12 45.1 10.1 0.13 12.7 0.2 6.4 3 2 4 7 7 6 4 HEAT repeats V-ATPase_H_N PF03224.14 PIK38863.1 - 5.1e-10 39.1 5.3 2.7e-08 33.5 0.8 3.3 2 1 0 2 2 2 1 V-ATPase subunit H HEAT PF02985.22 PIK38863.1 - 1.2e-07 31.3 23.1 0.17 12.3 0.1 9.1 9 0 0 9 9 9 1 HEAT repeat Arm_2 PF04826.13 PIK38863.1 - 0.00049 19.6 4.4 0.015 14.7 0.5 3.1 1 1 2 3 3 3 1 Armadillo-like UNC45-central PF11701.8 PIK38863.1 - 0.0017 18.4 2.9 0.24 11.4 0.8 2.9 2 1 0 2 2 2 2 Myosin-binding striated muscle assembly central KAP PF05804.12 PIK38863.1 - 0.0041 15.3 0.2 0.0065 14.7 0.2 1.2 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) WAPL PF07814.13 PIK38863.1 - 0.0059 15.4 0.9 0.0059 15.4 0.9 2.8 3 0 0 3 3 3 1 Wings apart-like protein regulation of heterochromatin Peroxidase_ext PF11895.8 PIK38863.1 - 0.059 13.3 0.2 3.4 7.6 0.2 3.2 1 1 2 3 3 3 0 Fungal peroxidase extension region RTTN_N PF14726.6 PIK38863.1 - 0.06 14.1 0.2 59 4.6 0.0 4.5 3 2 2 5 5 5 0 Rotatin, an armadillo repeat protein, centriole functioning Cnd1 PF12717.7 PIK38863.1 - 0.094 12.7 7.9 6.5 6.8 0.9 3.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 E3_UbLigase_EDD PF11547.8 PIK38864.1 - 1.2e-05 24.8 4.9 3.8e-05 23.3 4.9 1.9 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD TBCC_N PF16752.5 PIK38864.1 - 7 7.1 7.7 2.4 8.6 0.2 2.7 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PABP PF00658.18 PIK38865.1 - 1.1e-18 67.2 0.0 1.9e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain HECT PF00632.25 PIK38865.1 - 2.3e-12 47.0 0.0 3.2e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) OHCU_decarbox PF09349.10 PIK38865.1 - 0.87 10.1 0.1 0.87 10.1 0.1 2.0 2 0 0 2 2 2 0 OHCU decarboxylase HECT PF00632.25 PIK38866.1 - 4.2e-34 118.4 0.0 4.9e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) LRR_8 PF13855.6 PIK38867.1 - 6.1e-24 83.6 18.7 1.3e-10 40.9 3.0 5.5 5 1 1 6 6 6 3 Leucine rich repeat LRR_4 PF12799.7 PIK38867.1 - 1.8e-17 63.1 14.6 0.00056 20.2 0.6 6.4 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK38867.1 - 4e-17 62.4 0.2 5.6e-09 36.0 0.1 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK38867.1 - 0.0014 18.2 4.7 0.81 9.2 0.0 2.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK38867.1 - 1 10.1 18.5 27 5.9 0.0 7.0 9 0 0 9 9 9 0 Leucine Rich Repeat PsbT PF01405.17 PIK38868.1 - 4.7 7.1 6.2 1.8 8.5 2.3 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre T protein BLACT_WH PF17778.1 PIK38869.1 - 1.1e-17 63.7 0.2 2.7e-17 62.5 0.1 1.7 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 PIK38869.1 - 3.6e-15 56.5 0.2 6.8e-15 55.6 0.2 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK38869.1 - 0.00011 21.8 0.0 0.00023 20.7 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 PIK38869.1 - 0.048 13.1 0.1 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Pkinase PF00069.25 PIK38870.1 - 1.7e-70 237.4 0.0 2.1e-69 233.8 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38870.1 - 1.2e-52 178.7 0.0 4.9e-52 176.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 PIK38870.1 - 7.1e-23 80.4 6.3 1.8e-22 79.1 6.3 1.7 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 PIK38870.1 - 2.5e-07 29.8 0.0 5.7e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK38870.1 - 0.018 14.4 0.1 0.16 11.3 0.0 2.2 2 1 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 PIK38870.1 - 0.028 13.4 0.2 6.2 5.6 0.1 2.3 1 1 0 2 2 2 0 Haspin like kinase domain Myb_DNA-bind_5 PF13873.6 PIK38870.1 - 0.11 12.6 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF4144 PF13642.6 PIK38871.1 - 0.065 13.8 0.0 0.19 12.3 0.0 1.8 1 0 0 1 1 1 0 protein structure with unknown function RRM_1 PF00076.22 PIK38873.1 - 8.3e-10 38.4 0.0 1.4e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK38873.1 - 0.081 12.8 0.0 0.2 11.6 0.0 1.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif SET PF00856.28 PIK38875.1 - 5e-22 79.1 2.9 6e-22 78.8 1.1 2.0 2 1 0 2 2 2 1 SET domain N-SET PF11764.8 PIK38875.1 - 6.8e-14 52.3 0.8 1.1e-13 51.6 0.8 1.3 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N RRM_9 PF18444.1 PIK38875.1 - 0.086 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Septin PF00735.18 PIK38876.1 - 5.1e-105 350.8 2.6 4.3e-104 347.7 2.6 1.9 1 1 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 PIK38876.1 - 7.3e-09 35.7 0.1 1.7e-08 34.5 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK38876.1 - 6e-07 29.5 0.4 1.4e-05 25.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 PIK38876.1 - 7.7e-06 25.4 0.1 1.4e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 PIK38876.1 - 0.00049 19.7 0.1 0.0013 18.3 0.1 1.8 1 1 0 1 1 1 1 Ras family AAA_16 PF13191.6 PIK38876.1 - 0.00088 19.7 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 PIK38876.1 - 0.0014 18.2 0.2 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 PIK38876.1 - 0.0045 17.5 0.7 0.0085 16.6 0.5 1.8 1 1 0 1 1 1 1 ABC transporter Roc PF08477.13 PIK38876.1 - 0.0064 16.7 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 PIK38876.1 - 0.016 15.4 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 PIK38876.1 - 0.018 15.1 2.9 2 8.5 0.4 2.6 1 1 1 2 2 2 0 Dynamin family AAA_29 PF13555.6 PIK38876.1 - 0.025 14.3 0.1 0.06 13.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 PIK38876.1 - 0.026 14.1 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 PIK38876.1 - 0.081 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Pox_A32 PF04665.12 PIK38876.1 - 0.091 12.2 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein NACHT PF05729.12 PIK38876.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain WD40 PF00400.32 PIK38877.1 - 4.5e-25 87.4 11.4 1.5e-05 25.6 0.3 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK38877.1 - 1.5e-14 54.1 0.0 0.01 16.1 0.0 5.7 3 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK38877.1 - 1.6e-11 43.7 0.0 0.0028 16.7 0.0 4.8 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK38877.1 - 3.7e-06 27.0 0.0 0.0068 16.3 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK38877.1 - 3.4e-05 22.7 0.0 0.049 12.3 0.1 2.7 3 0 0 3 3 3 2 Nucleoporin Nup120/160 SOCS_box PF07525.16 PIK38877.1 - 0.00011 22.4 0.6 0.00023 21.4 0.6 1.6 1 0 0 1 1 1 1 SOCS box Nbas_N PF15492.6 PIK38877.1 - 0.045 13.1 0.4 1.7 7.9 0.0 3.4 4 1 1 5 5 5 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 PIK38877.1 - 1.1 9.2 6.3 7.8 6.6 0.0 4.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Pkinase PF00069.25 PIK38878.1 - 1.1e-65 221.7 0.0 1.7e-65 221.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38878.1 - 4.7e-32 111.3 0.0 6.3e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 PIK38878.1 - 5.6e-11 43.0 2.1 5.6e-11 43.0 2.1 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 PIK38878.1 - 3.9e-05 23.1 0.0 0.00025 20.5 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK38878.1 - 0.00013 20.9 0.0 0.00024 20.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 PIK38878.1 - 0.00088 19.0 0.1 1.2 8.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 PIK38878.1 - 0.037 13.9 0.0 0.15 11.9 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK38878.1 - 0.054 12.8 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK38878.1 - 0.18 10.7 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain 2OG-FeII_Oxy_2 PF13532.6 PIK38879.1 - 3.2e-32 112.3 0.1 4.1e-32 112.0 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Foie-gras_1 PF11817.8 PIK38880.1 - 2.4e-70 237.1 0.3 5e-70 236.1 0.3 1.6 1 0 0 1 1 1 1 Foie gras liver health family 1 TPR_6 PF13174.6 PIK38880.1 - 1.5 9.6 5.2 2.1 9.2 0.2 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat zf-SCNM1 PF15803.5 PIK38880.1 - 7.7 6.3 6.0 0.6 9.8 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of sodium channel modifier 1 RWD PF05773.22 PIK38881.1 - 1.2e-12 48.1 0.9 3.5e-12 46.6 0.9 1.8 1 1 0 1 1 1 1 RWD domain Pur_ac_phosph_N PF16656.5 PIK38881.1 - 0.049 14.2 0.0 1.7 9.3 0.0 2.4 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain SEEEED PF14797.6 PIK38883.1 - 4.6 7.4 21.3 0.14 12.3 14.6 1.7 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex CCDC106 PF15794.5 PIK38883.1 - 7.9 6.1 14.3 0.83 9.3 10.1 1.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 tRNA_U5-meth_tr PF05958.11 PIK38885.1 - 5.8e-15 55.1 0.0 2.2e-14 53.3 0.0 1.9 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 PIK38885.1 - 9.3e-08 32.0 0.0 2.2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK38885.1 - 1.6e-07 31.9 0.1 4e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 PIK38885.1 - 1.6e-06 27.8 0.0 4e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_4 PF02390.17 PIK38885.1 - 1.8e-05 24.3 0.0 3.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 PIK38885.1 - 0.00015 22.3 0.0 0.0004 21.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK38885.1 - 0.00021 20.9 0.1 0.00039 20.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 PIK38885.1 - 0.00088 18.7 0.0 0.0019 17.5 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 PIK38885.1 - 0.012 15.2 0.2 0.062 12.9 0.1 2.0 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 PIK38885.1 - 0.022 14.2 0.2 0.046 13.1 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DnaI_N PF07319.11 PIK38885.1 - 0.031 15.0 0.0 0.12 13.1 0.0 2.0 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus Methyltransf_32 PF13679.6 PIK38885.1 - 0.06 13.3 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK38885.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 PIK38885.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) rve PF00665.26 PIK38886.1 - 1.3e-19 70.6 0.0 2.3e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38886.1 - 1.6e-09 37.7 0.9 3.7e-09 36.5 0.9 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK38886.1 - 1e-06 28.4 0.9 4.4e-06 26.4 0.2 2.5 3 0 0 3 3 3 1 Integrase core domain RVT_1 PF00078.27 PIK38887.1 - 1e-24 87.3 0.0 1.5e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK38887.1 - 0.032 14.4 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Vinculin PF01044.19 PIK38889.1 - 3.4e-45 154.7 2.8 4.2e-45 154.4 2.8 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 PIK38889.1 - 0.00037 20.8 1.8 0.00072 19.8 1.7 1.5 1 1 0 1 1 1 1 I/LWEQ domain Vinculin PF01044.19 PIK38890.1 - 1.1e-231 772.0 29.9 1.9e-139 466.6 14.9 2.1 1 1 1 2 2 2 2 Vinculin family DUF2935 PF11155.8 PIK38890.1 - 0.28 11.5 4.0 5.7 7.3 0.0 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) YtxH PF12732.7 PIK38890.1 - 1.6 9.3 7.3 16 6.1 1.1 4.0 2 1 0 2 2 2 0 YtxH-like protein AAA_32 PF13654.6 PIK38890.1 - 2.2 6.9 13.2 3.8 6.2 0.2 3.8 3 1 1 4 4 4 0 AAA domain WXG100 PF06013.12 PIK38890.1 - 7.1 6.9 6.8 46 4.3 0.0 4.7 6 1 0 6 6 6 0 Proteins of 100 residues with WXG Cation_ATPase_C PF00689.21 PIK38891.1 - 3e-23 82.5 0.0 4.7e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 PIK38891.1 - 5.2e-16 59.6 0.1 9.8e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 PIK38891.1 - 0.002 17.9 3.0 0.0022 17.8 1.4 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 PIK38892.1 - 8.4e-50 168.8 2.3 1.1e-49 168.4 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 PIK38892.1 - 1e-18 66.7 0.0 1.9e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 PIK38892.1 - 0.019 15.3 0.1 0.043 14.1 0.1 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NUC153 PF08159.12 PIK38892.1 - 0.16 11.8 0.7 0.59 10.0 0.1 2.1 2 0 0 2 2 2 0 NUC153 domain SPC12 PF06645.13 PIK38892.1 - 2.6 8.2 7.6 2.9 8.1 1.3 2.4 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) EF-hand_1 PF00036.32 PIK38893.1 - 1.3e-19 68.2 11.8 2.7e-05 23.4 0.2 5.9 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 PIK38893.1 - 6.2e-19 66.3 17.0 6.6e-05 22.5 0.1 6.6 6 2 1 7 7 7 5 EF-hand domain EF-hand_7 PF13499.6 PIK38893.1 - 4.6e-18 65.4 11.6 1.2e-09 38.5 0.1 3.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 PIK38893.1 - 1.1e-12 46.8 4.8 0.00048 19.5 0.0 5.2 5 0 0 5 5 5 3 EF hand EF-hand_10 PF14788.6 PIK38893.1 - 1.7e-05 24.6 2.2 0.42 10.5 0.4 4.6 3 1 1 4 4 4 1 EF hand EF-hand_8 PF13833.6 PIK38893.1 - 0.00028 20.7 12.4 0.03 14.2 0.2 4.9 3 3 1 4 4 4 3 EF-hand domain pair Caleosin PF05042.13 PIK38893.1 - 0.0041 17.1 0.3 0.089 12.7 0.0 2.9 2 2 1 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 PIK38893.1 - 0.39 11.0 3.4 15 6.0 0.5 3.8 2 1 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EamA PF00892.20 PIK38895.1 - 2.6e-15 56.8 35.9 3.8e-11 43.3 12.8 2.0 2 0 0 2 2 2 2 EamA-like transporter family EF-hand_1 PF00036.32 PIK38896.1 - 2.3e-12 45.5 3.3 3.4e-07 29.4 0.4 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 PIK38896.1 - 3.5e-10 40.2 0.5 7.2e-06 26.4 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK38896.1 - 1e-09 37.5 5.7 4.6e-05 23.0 0.8 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK38896.1 - 1.2e-09 37.3 6.7 6.8e-06 25.3 0.2 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 PIK38896.1 - 6.6e-09 35.5 0.8 5.2e-06 26.2 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.6 PIK38896.1 - 0.014 15.2 0.3 0.039 13.8 0.1 1.8 2 0 0 2 2 2 0 EF hand Exo5 PF09810.9 PIK38896.1 - 0.099 12.1 0.3 0.3 10.5 0.1 1.7 1 1 0 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease Pox_MCEL PF03291.16 PIK38897.1 - 0.002 17.3 0.1 0.002 17.3 0.1 1.6 2 0 0 2 2 2 1 mRNA capping enzyme AAA_11 PF13086.6 PIK38897.1 - 0.47 10.2 5.0 0.57 9.9 5.0 1.0 1 0 0 1 1 1 0 AAA domain Sushi PF00084.20 PIK38898.1 - 1e-23 83.7 11.9 8.4e-09 35.9 0.2 3.3 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) cEGF PF12662.7 PIK38898.1 - 0.19 11.7 6.1 5.2 7.1 0.1 3.9 3 0 0 3 3 3 0 Complement Clr-like EGF-like Trypsin PF00089.26 PIK38899.1 - 1.4e-52 178.7 0.0 2e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin VWA PF00092.28 PIK38899.1 - 5.2e-35 121.2 0.1 9.1e-35 120.5 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK38899.1 - 6e-12 46.2 0.1 1.1e-11 45.3 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1986 PF09342.11 PIK38899.1 - 8.7e-06 26.1 0.0 1.7e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK38899.1 - 7.1e-05 23.7 0.0 0.00016 22.6 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain VWA_3 PF13768.6 PIK38899.1 - 8.4e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK38899.1 - 0.011 15.1 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Sushi PF00084.20 PIK38900.1 - 5.8e-05 23.6 0.4 9e-05 23.0 0.4 1.3 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Galactosyl_T PF01762.21 PIK38901.1 - 6e-49 166.5 0.1 7.7e-49 166.2 0.1 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK38901.1 - 0.018 14.5 0.2 0.036 13.5 0.2 1.7 1 1 0 1 1 1 0 Fringe-like TNFR_16_TM PF18422.1 PIK38901.1 - 0.1 12.5 0.3 0.35 10.9 0.3 1.9 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain ParA PF10609.9 PIK38902.1 - 5.2e-99 330.7 0.2 7e-99 330.2 0.2 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 PIK38902.1 - 7.2e-11 42.2 0.0 1.6e-10 41.1 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 PIK38902.1 - 3.7e-06 27.0 0.6 3.1e-05 24.0 0.3 2.1 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 PIK38902.1 - 0.00016 20.9 0.2 0.00089 18.5 0.3 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 PIK38902.1 - 0.00022 20.6 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 PIK38902.1 - 0.00094 18.7 0.0 0.64 9.4 0.1 2.4 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 PIK38902.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 PIK38902.1 - 0.07 13.0 0.9 0.87 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 PIK38902.1 - 0.12 11.5 0.1 0.25 10.5 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.16 PIK38902.1 - 0.14 11.6 0.1 0.66 9.4 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein zf-ribbon_3 PF13248.6 PIK38902.1 - 0.79 9.2 3.4 0.35 10.4 0.7 1.8 2 0 0 2 2 2 0 zinc-ribbon domain TPR_2 PF07719.17 PIK38903.1 - 6.9e-16 57.0 3.1 0.0011 18.9 0.3 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK38903.1 - 1.3e-11 43.8 3.8 0.011 15.6 0.5 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat SH3_1 PF00018.28 PIK38903.1 - 6.7e-11 41.6 0.0 1.3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK38903.1 - 1.9e-09 37.2 0.0 3.3e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK38903.1 - 8.4e-09 35.0 0.0 1.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TPR_7 PF13176.6 PIK38903.1 - 1.1e-06 28.2 0.1 2.5 8.3 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK38903.1 - 9.5e-06 25.4 1.2 0.18 12.1 0.3 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK38903.1 - 0.00015 22.0 2.7 0.18 12.1 0.2 4.5 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK38903.1 - 0.00025 20.7 0.0 0.86 9.3 0.0 4.8 4 1 2 6 6 6 1 TPR repeat TPR_16 PF13432.6 PIK38903.1 - 0.00099 19.7 0.0 0.53 11.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK38903.1 - 0.0023 18.2 0.9 2.5 8.7 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK38903.1 - 0.031 14.9 0.0 2.3e+02 2.8 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK38903.1 - 0.055 14.0 0.1 1.2 9.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Filamin PF00630.19 PIK38904.1 - 1.2e-13 51.7 0.0 2.6e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.24 PIK38904.1 - 1.9e-06 27.9 15.2 1.9e-06 27.9 15.2 3.4 3 0 0 3 3 3 2 B-box zinc finger DUF2457 PF10446.9 PIK38904.1 - 5.8e-05 22.4 10.0 9.4e-05 21.7 10.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Invasin_D3 PF09134.10 PIK38904.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Invasin, domain 3 MMR_HSR1 PF01926.23 PIK38905.1 - 2.3e-13 50.2 0.0 2.9e-12 46.7 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK38905.1 - 3.1e-05 23.5 0.0 0.00041 19.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK38905.1 - 3.9e-05 23.6 0.0 0.00088 19.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 PIK38905.1 - 7.6 6.6 7.7 0.64 10.0 0.1 3.0 4 1 1 5 5 5 0 Dynamin family Glyco_transf_10 PF00852.19 PIK38906.1 - 9.2e-47 159.0 2.9 1.3e-46 158.5 2.9 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK38906.1 - 9.2e-09 35.7 0.0 1.8e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Trypsin PF00089.26 PIK38907.1 - 1.3e-05 25.1 0.0 2.5e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Trypsin HrpJ PF07201.11 PIK38907.1 - 0.017 15.4 1.6 0.034 14.5 1.6 1.4 1 0 0 1 1 1 0 HrpJ-like domain Trypsin_2 PF13365.6 PIK38907.1 - 0.054 14.4 0.0 0.1 13.5 0.0 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain AAA PF00004.29 PIK38908.1 - 5.8e-06 26.8 0.2 2.8e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK38908.1 - 3.1e-05 24.5 0.9 0.00066 20.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK38908.1 - 4.6e-05 23.9 0.3 0.029 14.7 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 PIK38908.1 - 7e-05 22.9 0.0 0.00025 21.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK38908.1 - 7.7e-05 23.0 0.0 0.0002 21.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 PIK38908.1 - 7.8e-05 22.7 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK38908.1 - 8e-05 22.9 9.2 0.0015 18.8 0.1 3.7 3 1 1 4 4 4 1 AAA domain IstB_IS21 PF01695.17 PIK38908.1 - 0.00015 21.6 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 PIK38908.1 - 0.0002 20.9 0.0 0.00049 19.6 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.6 PIK38908.1 - 0.00052 19.6 1.0 0.0021 17.6 0.0 2.4 2 1 1 3 3 2 1 AAA domain AAA_33 PF13671.6 PIK38908.1 - 0.00071 19.8 2.1 0.012 15.7 0.2 3.1 2 1 0 2 2 2 1 AAA domain DUF4201 PF13870.6 PIK38908.1 - 0.0022 17.7 21.9 0.016 14.9 3.7 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4201) AAA_19 PF13245.6 PIK38908.1 - 0.0058 17.0 0.2 0.018 15.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_7 PF12775.7 PIK38908.1 - 0.0078 15.7 0.6 0.033 13.7 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 PIK38908.1 - 0.009 15.9 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 PIK38908.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK38908.1 - 0.016 15.1 2.6 0.027 14.4 0.0 2.5 3 0 0 3 3 2 0 RsgA GTPase ResIII PF04851.15 PIK38908.1 - 0.019 15.0 0.1 0.35 10.9 0.0 2.6 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 PIK38908.1 - 0.019 15.2 0.5 0.062 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 PIK38908.1 - 0.033 13.6 0.1 0.1 11.9 0.0 1.8 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI DEAD PF00270.29 PIK38908.1 - 0.045 13.5 0.4 0.28 10.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase PduV-EutP PF10662.9 PIK38908.1 - 0.052 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Cep57_MT_bd PF06657.13 PIK38908.1 - 0.069 13.6 6.8 6.8 7.2 0.0 3.5 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 NTPase_1 PF03266.15 PIK38908.1 - 0.074 13.0 0.9 0.88 9.5 0.0 2.5 2 0 0 2 2 2 0 NTPase Sigma54_activat PF00158.26 PIK38908.1 - 0.086 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF812 PF05667.11 PIK38908.1 - 0.096 11.5 21.7 1.2 7.9 14.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Fez1 PF06818.15 PIK38908.1 - 0.1 13.1 19.2 0.13 12.7 5.4 2.5 2 0 0 2 2 2 0 Fez1 ATG16 PF08614.11 PIK38908.1 - 0.26 11.5 21.0 0.039 14.2 2.3 2.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 PIK38908.1 - 0.33 9.8 16.2 1.7 7.5 2.0 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 PIK38908.1 - 0.6 10.2 19.5 2.5 8.2 5.5 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ABC_tran PF00005.27 PIK38908.1 - 0.79 10.2 0.0 0.79 10.2 0.0 4.1 4 1 1 5 5 5 0 ABC transporter CENP-F_leu_zip PF10473.9 PIK38908.1 - 0.89 9.6 25.0 4.5 7.3 10.1 3.1 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 PIK38908.1 - 1.8 7.8 13.7 6.1 6.1 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 PIK38908.1 - 2.3 8.4 16.7 5.9 7.1 8.2 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ORF6C PF10552.9 PIK38908.1 - 2.7 8.1 8.7 0.47 10.6 3.7 2.3 3 0 0 3 3 1 0 ORF6C domain FAM76 PF16046.5 PIK38908.1 - 3 7.1 24.8 5.6 6.2 1.3 2.4 1 1 1 2 2 2 0 FAM76 protein YabA PF06156.13 PIK38908.1 - 3 8.5 11.2 5.2 7.8 5.1 2.9 2 0 0 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 PIK38908.1 - 3.5 7.7 15.5 5.5 7.1 7.9 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TolA_bind_tri PF16331.5 PIK38908.1 - 3.6 7.7 18.8 8.1 6.6 2.8 2.9 2 1 0 2 2 2 0 TolA binding protein trimerisation Sulfotransfer_1 PF00685.27 PIK38909.1 - 3.4e-10 39.8 0.0 1.6e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK38909.1 - 6.9e-09 36.4 0.0 2.1e-08 34.8 0.0 1.7 1 1 1 2 2 2 1 Sulfotransferase family Methyltransf_5 PF01795.19 PIK38909.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family Sulfotransfer_1 PF00685.27 PIK38910.1 - 1.1e-11 44.7 0.1 8.2e-11 41.9 0.0 2.0 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK38910.1 - 6.7e-08 33.2 0.0 1.7e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Sulfotransferase family SepF PF04472.12 PIK38910.1 - 0.068 13.5 0.0 0.36 11.1 0.0 2.1 2 0 0 2 2 2 0 Cell division protein SepF 2OG-FeII_Oxy_2 PF13532.6 PIK38910.1 - 0.13 12.4 0.1 0.82 9.8 0.0 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily VIR_N PF15912.5 PIK38911.1 - 2.1e-35 122.6 2.8 2.1e-35 122.6 2.8 2.6 1 1 1 2 2 2 1 Virilizer, N-terminal Fes1 PF08609.10 PIK38911.1 - 0.062 14.2 0.1 1.2 10.0 0.1 3.0 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 TAF1_subA PF14929.6 PIK38911.1 - 0.16 11.3 1.3 0.39 10.1 1.3 1.8 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A DHHC PF01529.20 PIK38912.1 - 1.1e-31 109.7 9.7 1.1e-31 109.7 9.7 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Wzy_C PF04932.15 PIK38912.1 - 0.031 13.9 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 0 O-Antigen ligase DUF2207 PF09972.9 PIK38912.1 - 0.72 8.5 1.8 0.79 8.4 0.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CDC45 PF02724.14 PIK38912.1 - 1.1 7.4 4.1 1.4 7.1 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RabGAP-TBC PF00566.18 PIK38913.1 - 4.3e-24 85.4 0.4 6.2e-24 84.8 0.4 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4279 PF14106.6 PIK38913.1 - 0.097 12.9 0.0 0.52 10.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4279) adh_short PF00106.25 PIK38914.1 - 3.1e-41 141.0 0.3 4e-41 140.6 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38914.1 - 2.2e-33 115.8 0.0 2.8e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38914.1 - 4.1e-10 39.9 0.1 6.2e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF2316 PF10078.9 PIK38914.1 - 0.016 15.4 0.0 0.033 14.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) adh_short PF00106.25 PIK38915.1 - 2e-35 122.0 0.1 2.6e-35 121.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38915.1 - 1.7e-24 86.7 0.0 2.1e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38915.1 - 0.0002 21.3 0.0 0.00026 21.0 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF2316 PF10078.9 PIK38915.1 - 0.0056 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) adh_short PF00106.25 PIK38916.1 - 1.1e-48 165.3 1.3 1.9e-48 164.6 1.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38916.1 - 8.3e-37 127.0 0.1 1.7e-36 125.9 0.1 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK38916.1 - 8.2e-10 38.9 0.2 1.7e-09 37.8 0.2 1.4 1 0 0 1 1 1 1 KR domain TPR_12 PF13424.6 PIK38916.1 - 0.00022 21.5 0.0 0.064 13.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK38916.1 - 0.018 15.1 0.5 3 8.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Epimerase PF01370.21 PIK38916.1 - 0.19 11.2 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pkinase PF00069.25 PIK38917.1 - 1.8e-32 112.8 0.0 2e-24 86.4 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK38917.1 - 3.2e-11 43.0 0.5 2.6e-10 40.0 0.5 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 PIK38917.1 - 1.3e-09 37.8 0.0 2.6e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APH PF01636.23 PIK38917.1 - 0.0001 22.3 0.0 0.00086 19.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK38917.1 - 0.063 12.9 0.3 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 RIO1 family V_ATPase_I PF01496.19 PIK38918.1 - 3.4e-181 604.1 0.0 3.9e-181 604.0 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RPW8 PF05659.11 PIK38918.1 - 0.11 12.2 1.4 0.22 11.2 0.9 1.7 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 V_ATPase_I PF01496.19 PIK38919.1 - 1.1e-106 357.7 13.5 7.3e-77 259.1 0.0 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family Acyltransferase PF01553.21 PIK38920.1 - 1.7e-29 102.2 0.0 2.5e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase SPOC PF07744.13 PIK38920.1 - 0.031 14.2 0.1 0.1 12.5 0.1 1.6 1 1 0 1 1 1 0 SPOC domain Prefoldin_2 PF01920.20 PIK38920.1 - 0.068 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Prefoldin subunit DUF3382 PF11862.8 PIK38920.1 - 0.078 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) adh_short PF00106.25 PIK38921.1 - 7.8e-20 71.2 0.0 1e-18 67.5 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38921.1 - 1.3e-15 57.6 0.0 7e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase QRPTase_C PF01729.19 PIK38921.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Inositol_P PF00459.25 PIK38922.1 - 2.2e-24 86.4 1.0 4.4e-16 59.2 0.0 2.0 1 1 1 2 2 2 2 Inositol monophosphatase family zf-C3HC4_2 PF13923.6 PIK38923.1 - 0.00031 20.5 8.1 0.001 18.8 8.1 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK38923.1 - 0.00081 19.2 7.1 0.0023 17.8 7.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK38923.1 - 0.0011 18.9 7.7 0.0053 16.7 7.8 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK38923.1 - 0.0013 19.0 8.0 0.0013 19.0 8.0 2.1 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 PIK38923.1 - 0.0033 17.3 6.3 0.0033 17.3 6.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK38923.1 - 0.01 15.9 7.9 0.01 15.9 7.9 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK38923.1 - 0.1 12.8 6.3 0.32 11.2 6.3 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 PIK38923.1 - 0.25 11.6 7.1 1.2 9.5 7.1 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK38923.1 - 0.64 10.1 6.6 0.054 13.6 1.4 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 PIK38923.1 - 3.6 7.5 12.3 0.43 10.5 6.7 2.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 BIR PF00653.21 PIK38924.1 - 9.5e-21 74.2 4.0 1.8e-20 73.4 4.0 1.5 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain WD40 PF00400.32 PIK38924.1 - 0.12 13.2 2.3 0.14 13.1 0.4 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF1057 PF06342.12 PIK38925.1 - 4.3e-18 65.4 0.0 5.7e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_1 PF00561.20 PIK38925.1 - 1.4e-10 41.2 0.1 4.7e-10 39.5 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK38925.1 - 4.2e-09 36.0 0.0 1.7e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK38925.1 - 3.9e-08 34.2 0.0 7.8e-08 33.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 PIK38925.1 - 0.00076 19.4 0.2 0.12 12.3 0.1 2.2 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_5 PF12695.7 PIK38925.1 - 0.028 14.2 0.1 2 8.2 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family Ribosomal_S13_N PF08069.12 PIK38926.1 - 4.4e-32 109.9 0.1 5.2e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain HTH_38 PF13936.6 PIK38926.1 - 0.039 13.7 0.0 0.081 12.7 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain BH4 PF02180.17 PIK38926.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Bcl-2 homology region 4 LINES_C PF14695.6 PIK38926.1 - 0.16 11.4 0.1 0.37 10.3 0.0 1.6 2 0 0 2 2 2 0 Lines C-terminus Complex1_LYR PF05347.15 PIK38927.1 - 4e-10 39.6 0.0 6.9e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 PIK38927.1 - 6.4e-07 30.0 0.3 9.1e-07 29.5 0.3 1.3 1 1 0 1 1 1 1 Complex1_LYR-like DUF448 PF04296.13 PIK38927.1 - 0.0045 16.8 0.1 0.0071 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF448) 5_nucleotid_C PF02872.18 PIK38928.1 - 1.4e-06 28.6 0.0 2.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Lactamase_B_2 PF12706.7 PIK38929.1 - 4.4e-21 75.3 0.0 5.9e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK38929.1 - 6.5e-10 39.1 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain YABBY PF04690.13 PIK38930.1 - 8.3 7.0 16.8 22 5.6 2.5 3.7 1 1 3 4 4 4 0 YABBY protein DUF4456 PF14644.6 PIK38931.1 - 0.013 15.2 0.4 0.023 14.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) Plavaka PF18759.1 PIK38931.1 - 0.03 13.5 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Plavaka transposase HEPN PF05168.14 PIK38933.1 - 2.7e-08 33.9 0.3 2.7e-07 30.7 0.0 2.8 3 0 0 3 3 3 1 HEPN domain DnaJ PF00226.31 PIK38933.1 - 0.0003 20.9 0.0 0.0014 18.7 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain CtIP_N PF10482.9 PIK38936.1 - 0.46 10.5 7.4 1 9.4 7.4 1.6 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Scramblase PF03803.15 PIK38937.1 - 4e-19 68.8 0.4 1.2e-18 67.2 0.1 1.8 2 0 0 2 2 2 1 Scramblase Scramblase PF03803.15 PIK38938.1 - 1.6e-45 155.1 0.0 2e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Scramblase FYVE PF01363.21 PIK38939.1 - 1.7e-07 31.3 18.1 5.3e-06 26.5 1.8 2.8 3 0 0 3 3 3 2 FYVE zinc finger Smg4_UPF3 PF03467.15 PIK38940.1 - 6.4e-51 172.8 0.2 6.4e-51 172.8 0.2 3.4 2 1 1 3 3 3 1 Smg-4/UPF3 family SID-1_RNA_chan PF13965.6 PIK38940.1 - 2.9 6.2 5.7 5.2 5.4 5.7 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Guanylate_cyc PF00211.20 PIK38941.1 - 1.6e-68 229.9 0.1 2.4e-68 229.4 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK38941.1 - 2.1e-43 148.3 9.1 2.1e-43 148.3 9.1 2.9 3 1 0 3 3 3 1 Heme NO binding associated AMP-binding PF00501.28 PIK38941.1 - 0.047 12.3 0.0 0.082 11.5 0.0 1.3 1 0 0 1 1 1 0 AMP-binding enzyme MctB PF11382.8 PIK38941.1 - 0.27 10.9 3.0 0.18 11.5 1.1 1.6 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB Mito_carr PF00153.27 PIK38942.1 - 1.5e-35 121.0 0.1 5.2e-18 64.8 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Lipoxygenase PF00305.19 PIK38943.1 - 6.3e-64 216.6 0.0 1e-63 215.9 0.0 1.3 1 0 0 1 1 1 1 Lipoxygenase PLAT PF01477.23 PIK38943.1 - 9.1e-05 23.0 0.0 0.00017 22.1 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Lipoxygenase PF00305.19 PIK38944.1 - 5.6e-65 220.1 0.0 1.1e-64 219.0 0.0 1.4 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.23 PIK38944.1 - 6.7e-21 75.0 0.1 1.2e-20 74.2 0.1 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain ATS3 PF06232.11 PIK38944.1 - 0.00062 19.7 0.1 0.0042 17.0 0.0 2.1 2 0 0 2 2 2 1 Embryo-specific protein 3, (ATS3) Abhydrolase_3 PF07859.13 PIK38945.1 - 1.3e-29 103.6 0.0 1.8e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK38945.1 - 0.00013 21.0 0.0 0.0011 18.0 0.0 1.9 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK38945.1 - 0.0037 16.8 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK38945.1 - 0.074 11.9 0.1 0.18 10.6 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 PIK38946.1 - 7.4e-15 55.4 0.0 9.8e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold FUN14 PF04930.15 PIK38948.1 - 3.4e-23 81.9 1.1 4.4e-23 81.5 1.1 1.1 1 0 0 1 1 1 1 FUN14 family RVT_N PF13655.6 PIK38948.1 - 0.0053 17.0 0.1 0.0079 16.4 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of reverse transcriptase SPC12 PF06645.13 PIK38948.1 - 0.16 12.1 1.1 0.34 11.0 0.2 1.8 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) HSP70 PF00012.20 PIK38949.1 - 2.9e-74 250.4 0.2 3.2e-74 250.2 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK38949.1 - 2.9e-07 29.6 1.7 4.4e-07 29.0 1.7 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Z1 PF10593.9 PIK38949.1 - 0.071 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Z1 domain Aldolase_II PF00596.21 PIK38950.1 - 9.9e-46 156.0 0.1 1.6e-45 155.3 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain LamB_YcsF PF03746.16 PIK38950.1 - 0.15 11.7 0.3 0.4 10.3 0.3 1.7 1 0 0 1 1 1 0 LamB/YcsF family DUF3652 PF12372.8 PIK38954.1 - 4.1e-14 52.2 0.2 1.5e-13 50.4 0.2 2.1 1 0 0 1 1 1 1 Huntingtin protein region DUF4686 PF15742.5 PIK38955.1 - 2.4e-26 92.8 53.8 3.3e-26 92.3 53.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) DivIC PF04977.15 PIK38955.1 - 0.001 18.8 4.0 0.001 18.8 4.0 5.7 2 2 4 6 6 6 1 Septum formation initiator bZIP_1 PF00170.21 PIK38955.1 - 0.084 13.0 0.3 0.084 13.0 0.3 5.2 4 1 2 6 6 6 0 bZIP transcription factor ATG16 PF08614.11 PIK38956.1 - 7.1e-05 23.1 11.8 7.1e-05 23.1 11.8 4.5 2 2 2 4 4 4 2 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 PIK38956.1 - 0.0091 16.2 11.1 0.0091 16.2 11.1 6.1 1 1 5 6 6 6 1 TATA element modulatory factor 1 TATA binding DNA_Packaging_2 PF11123.8 PIK38956.1 - 0.028 14.6 0.1 1.7 8.9 0.0 3.0 1 1 1 2 2 2 0 DNA packaging protein ECM1 PF05782.11 PIK38956.1 - 0.095 11.6 0.1 0.095 11.6 0.1 2.3 2 1 0 2 2 2 0 Extracellular matrix protein 1 (ECM1) ABC_membrane_2 PF06472.15 PIK38956.1 - 0.11 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Filament PF00038.21 PIK38956.1 - 0.4 10.2 59.7 0.097 12.2 20.4 3.2 1 1 2 3 3 3 0 Intermediate filament protein HAP1_N PF04849.13 PIK38956.1 - 1.5 8.0 66.6 0.11 11.7 24.7 3.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region COMP PF11598.8 PIK38956.1 - 3.6 8.2 11.9 0.84 10.2 0.4 3.9 4 0 0 4 4 4 0 Cartilage oligomeric matrix protein Toprim PF01751.22 PIK38956.1 - 7.2 6.9 7.7 2.2 8.5 3.7 2.5 2 1 0 2 2 2 0 Toprim domain DUF3584 PF12128.8 PIK38957.1 - 0.0096 13.5 21.3 0.011 13.3 21.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF572 PF04502.13 PIK38957.1 - 0.018 14.7 24.7 0.023 14.3 24.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4164 PF13747.6 PIK38957.1 - 0.46 10.8 20.9 1.5 9.2 1.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) XkdW PF09636.10 PIK38957.1 - 0.65 10.1 15.9 1.8 8.7 4.0 2.4 1 1 1 2 2 2 0 XkdW protein Fez1 PF06818.15 PIK38957.1 - 0.77 10.2 30.1 9.1 6.7 28.9 2.1 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 PIK38957.1 - 2.1 8.5 30.4 43 4.2 21.2 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 PIK38957.1 - 2.7 7.3 16.2 1.6 8.0 7.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TRAF_BIRC3_bd PF16673.5 PIK38957.1 - 4.1 7.3 17.8 1.3 8.8 3.7 2.9 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain RVT_1 PF00078.27 PIK38958.1 - 2.4e-13 50.1 0.0 1.6e-12 47.5 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK38959.1 - 1.3e-14 54.5 0.0 3.9e-14 52.9 0.0 1.9 2 0 0 2 2 2 1 NACHT domain DED PF01335.21 PIK38959.1 - 7.1e-05 23.0 0.2 0.031 14.6 0.1 2.9 2 0 0 2 2 2 1 Death effector domain AAA_25 PF13481.6 PIK38959.1 - 0.0014 18.2 0.0 0.0048 16.5 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 PIK38959.1 - 0.0019 18.6 0.0 0.0056 17.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 PIK38959.1 - 0.0065 15.7 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 PIK38959.1 - 0.0095 16.0 0.0 0.024 14.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase PF06745.13 PIK38959.1 - 0.011 15.2 0.0 0.024 14.0 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 PIK38959.1 - 0.013 16.0 0.0 0.074 13.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain NLRC4_HD2 PF17776.1 PIK38959.1 - 0.014 15.9 0.6 0.65 10.5 0.0 3.1 2 0 0 2 2 2 0 NLRC4 helical domain HD2 AAA_22 PF13401.6 PIK38959.1 - 0.017 15.4 0.0 0.05 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK38959.1 - 0.052 12.7 0.0 0.24 10.6 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 TyeA PF09059.10 PIK38959.1 - 0.096 12.8 0.9 0.97 9.6 0.0 2.7 3 0 0 3 3 3 0 TyeA AAA_16 PF13191.6 PIK38959.1 - 0.098 13.0 0.0 1.9 8.8 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain ZU5 PF00791.20 PIK38960.1 - 2e-14 53.7 0.0 4e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain UPA PF17217.3 PIK38960.1 - 0.00099 19.0 0.1 0.0016 18.3 0.1 1.3 1 0 0 1 1 1 1 UPA domain Fibrinogen_C PF00147.18 PIK38961.1 - 1.3e-08 34.9 1.0 0.0023 17.8 0.4 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38961.1 - 1.2e-05 25.5 13.5 1.9e-05 24.8 13.5 1.3 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK38962.1 - 6.8e-64 215.7 15.5 6.6e-38 130.7 12.7 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38962.1 - 3.6e-09 36.4 11.5 3.6e-09 36.4 11.5 4.6 2 2 2 4 4 4 1 TILa domain TIL PF01826.17 PIK38962.1 - 4.2e-07 30.1 16.5 4.2e-07 30.1 16.5 4.3 3 2 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38962.1 - 0.0049 17.0 10.8 0.0049 17.0 10.8 4.5 2 2 1 3 3 3 1 EGF domain EGF PF00008.27 PIK38962.1 - 0.027 14.8 7.8 0.027 14.8 7.8 4.6 3 1 0 3 3 3 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK38962.1 - 1.5 8.9 31.9 0.047 13.7 4.0 3.6 4 0 0 4 4 4 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK38963.1 - 4.1e-83 278.5 20.3 2.3e-42 145.3 16.3 2.4 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38963.1 - 1.1e-08 34.9 12.8 1.1e-08 34.9 12.8 4.6 3 1 2 5 5 5 1 TILa domain TIL PF01826.17 PIK38963.1 - 2.2e-06 27.8 15.9 2.2e-06 27.8 15.9 4.4 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38963.1 - 0.0026 17.9 13.0 0.0026 17.9 13.0 4.4 3 1 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK38964.1 - 2.2e-29 102.9 27.9 9.8e-18 64.8 0.7 4.2 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38964.1 - 2.4e-11 43.4 12.6 2.4e-11 43.4 12.6 5.5 3 2 3 6 6 6 1 TILa domain TIL PF01826.17 PIK38964.1 - 3.2e-06 27.3 15.2 3.2e-06 27.3 15.2 5.0 4 1 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38964.1 - 0.00067 19.8 11.0 0.00067 19.8 11.0 5.7 5 2 1 6 6 6 1 EGF domain Fibrinogen_C PF00147.18 PIK38965.1 - 4.5e-05 23.3 15.5 0.00011 22.1 14.8 1.7 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38966.1 - 2.7e-32 112.4 17.3 1.6e-31 109.8 17.3 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38966.1 - 5e-11 42.4 8.6 5e-11 42.4 8.6 4.6 2 2 2 4 4 4 1 TILa domain TIL PF01826.17 PIK38966.1 - 2e-06 27.9 16.4 2e-06 27.9 16.4 3.4 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK38967.1 - 8.1e-25 87.9 1.5 9.7e-25 87.7 1.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38968.1 - 6.9e-43 147.0 18.8 8e-42 143.5 18.8 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK38968.1 - 0.0001 22.5 6.9 0.0001 22.5 6.9 2.8 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK38969.1 - 2.1e-37 129.1 0.6 3.1e-30 105.6 0.5 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38969.1 - 2.3e-08 33.8 10.2 2.3e-08 33.8 10.2 3.6 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK38969.1 - 1.3e-05 25.3 15.9 1.3e-05 25.3 15.9 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Tme5_EGF_like PF09064.10 PIK38969.1 - 6.2 6.8 25.8 0.21 11.5 5.3 3.6 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like EGF_MSP1_1 PF12946.7 PIK38969.1 - 8.6 6.5 32.1 0.12 12.4 6.3 3.5 3 1 0 3 3 3 0 MSP1 EGF domain 1 cEGF PF12662.7 PIK38969.1 - 9.9 6.2 25.0 0.33 10.9 0.4 4.7 4 0 0 4 4 4 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK38970.1 - 6.5e-40 137.3 0.4 7.1e-40 137.2 0.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK38971.1 - 1.5e-22 80.5 0.1 2.3e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK38971.1 - 1.4e-09 37.8 11.9 1.4e-09 37.8 11.9 3.5 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK38971.1 - 6.6e-06 26.3 7.2 6.6e-06 26.3 7.2 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK38971.1 - 0.00084 19.5 10.0 0.00084 19.5 10.0 4.2 4 2 1 5 5 5 1 EGF domain Tme5_EGF_like PF09064.10 PIK38971.1 - 0.0052 16.7 8.3 0.0052 16.7 8.3 3.8 2 1 0 2 2 2 1 Thrombomodulin like fifth domain, EGF-like EGF_MSP1_1 PF12946.7 PIK38971.1 - 8.7 6.5 36.4 0.061 13.4 4.0 3.3 4 0 0 4 4 4 0 MSP1 EGF domain 1 F-box-like PF12937.7 PIK38972.1 - 2.8e-07 30.3 0.4 6.8e-07 29.1 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK38972.1 - 0.19 11.7 1.1 0.3 11.0 0.1 1.9 2 0 0 2 2 2 0 F-box domain adh_short PF00106.25 PIK38973.1 - 3e-16 59.5 0.0 8.6e-15 54.7 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK38973.1 - 1.7e-09 37.6 0.0 2.6e-08 33.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DFP PF04127.15 PIK38973.1 - 0.052 13.4 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Lig_chan PF00060.26 PIK38974.1 - 2.4e-40 137.8 0.2 4.9e-40 136.8 0.2 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK38974.1 - 1.1e-36 125.5 0.0 2.9e-36 124.1 0.0 1.7 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 PIK38974.1 - 3.2e-24 85.6 0.0 5.6e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 PIK38974.1 - 8.8 6.4 9.6 0.49 10.4 0.5 3.0 3 0 0 3 3 3 0 Ion channel C1-set PF07654.15 PIK38975.1 - 0.044 14.2 1.0 0.15 12.4 1.0 2.0 1 1 0 1 1 1 0 Immunoglobulin C1-set domain TSP_1 PF00090.19 PIK38977.1 - 2.7e-07 30.7 5.3 7.5e-07 29.3 5.3 1.8 1 0 0 1 1 1 1 Thrombospondin type 1 domain Cob_adeno_trans PF01923.18 PIK38978.1 - 1.1e-22 80.9 0.0 1.2e-22 80.8 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase RT_RNaseH_2 PF17919.1 PIK38979.1 - 2e-26 91.9 0.0 3.6e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK38979.1 - 3.6e-23 81.8 0.0 7.5e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK38979.1 - 3e-22 79.1 0.0 6.1e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38979.1 - 9.3e-20 70.5 0.9 1.8e-19 69.6 0.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK38979.1 - 7.9e-15 55.0 0.0 1.2e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK38979.1 - 0.0016 18.2 0.1 0.0044 16.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK38979.1 - 0.04 14.2 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 H2C2 zinc finger gag-asp_proteas PF13975.6 PIK38980.1 - 1.9e-05 25.1 0.3 5e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK38980.1 - 7.9e-05 23.2 0.1 0.00017 22.2 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK38980.1 - 0.00083 19.6 0.0 0.003 17.8 0.0 1.9 1 1 0 1 1 1 1 Retroviral aspartyl protease DUF2613 PF11021.8 PIK38980.1 - 0.85 9.8 9.9 6.6 6.9 2.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Tox-GHH PF15636.6 PIK38981.1 - 2.9e-20 72.0 0.1 6.4e-20 70.9 0.1 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin DUF4852 PF16144.5 PIK38981.1 - 0.098 12.8 0.2 0.55 10.4 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4852) Ribosomal_S26e PF01283.19 PIK38981.1 - 0.19 12.2 0.0 0.34 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S26e RHS_repeat PF05593.14 PIK38982.1 - 1.4e-11 44.6 20.2 0.00064 20.2 0.1 7.1 7 1 1 8 8 8 4 RHS Repeat NHL PF01436.21 PIK38983.1 - 1.7e-06 27.8 0.0 0.35 11.0 0.0 4.0 4 0 0 4 4 4 2 NHL repeat PAS PF00989.25 PIK38985.1 - 2.4e-13 50.1 0.0 1.6e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 PIK38985.1 - 1e-11 45.0 0.0 9.9e-05 22.6 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 PIK38985.1 - 7.1e-09 35.8 0.3 0.00031 20.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_9 PF13426.7 PIK38985.1 - 0.0047 17.2 0.0 0.12 12.6 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 PIK38985.1 - 0.0061 16.8 0.0 0.022 15.0 0.0 1.9 2 0 0 2 2 2 1 PAS fold I-set PF07679.16 PIK38986.1 - 1.3e-17 63.6 0.0 2.3e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK38986.1 - 2.8e-15 56.7 0.0 5.1e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK38986.1 - 1.7e-09 37.9 0.0 4.8e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK38986.1 - 2.9e-08 33.7 0.0 5.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK38986.1 - 1.3e-05 25.3 0.1 0.17 12.1 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin V-set domain EGF PF00008.27 PIK38986.1 - 0.0022 18.2 7.2 0.0022 18.2 7.2 5.5 6 0 0 6 6 6 1 EGF-like domain EGF_2 PF07974.13 PIK38986.1 - 0.003 17.9 8.9 0.003 17.9 8.9 5.5 5 1 0 5 5 5 2 EGF-like domain hEGF PF12661.7 PIK38986.1 - 0.015 15.9 6.3 0.015 15.9 6.3 6.9 7 0 0 7 7 7 0 Human growth factor-like EGF Rib_5-P_isom_A PF06026.14 PIK38987.1 - 1.7e-66 223.1 0.0 2.1e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 PIK38987.1 - 0.0012 18.8 0.2 0.23 11.4 0.0 2.5 2 1 1 3 3 3 2 DeoR C terminal sensor domain Sec63 PF02889.16 PIK38988.1 - 4.7e-90 301.2 0.8 7.7e-90 300.5 0.3 1.6 2 0 0 2 2 2 1 Sec63 Brl domain Helicase_PWI PF18149.1 PIK38988.1 - 9.2e-35 119.2 0.3 2.4e-34 117.8 0.3 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain DEAD PF00270.29 PIK38988.1 - 8.6e-33 113.6 0.1 2.9e-16 59.7 0.1 3.7 2 1 1 3 3 3 3 DEAD/DEAH box helicase ResIII PF04851.15 PIK38988.1 - 1e-16 61.4 0.0 3.6e-08 33.6 0.0 3.8 2 1 1 3 3 3 3 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK38988.1 - 2.1e-10 40.9 0.5 0.00012 22.4 0.0 4.0 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 PIK38988.1 - 0.0043 16.8 0.0 0.14 11.9 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 PIK38988.1 - 0.02 15.1 3.8 3.3 8.0 0.0 4.0 3 1 0 3 3 3 0 AAA domain PhoH PF02562.16 PIK38988.1 - 0.033 13.6 0.0 0.22 11.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Glyco_trans_4_5 PF16994.5 PIK38988.1 - 0.061 12.9 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Sec63 PF02889.16 PIK38989.1 - 4.3e-82 275.1 0.5 4.9e-82 274.9 0.5 1.0 1 0 0 1 1 1 1 Sec63 Brl domain DUF4391 PF14335.6 PIK38989.1 - 0.066 12.9 1.5 0.17 11.6 1.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) WTF PF03303.13 PIK38991.1 - 0.0013 18.5 0.2 0.0017 18.2 0.2 1.1 1 0 0 1 1 1 1 WTF protein DUF2417 PF10329.9 PIK38991.1 - 0.0071 15.8 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Region of unknown function (DUF2417) TMEM154 PF15102.6 PIK38991.1 - 0.0071 16.2 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 TMEM154 protein family SCIMP PF15050.6 PIK38991.1 - 0.032 14.7 0.7 0.054 13.9 0.7 1.4 1 0 0 1 1 1 0 SCIMP protein Orf78 PF06024.12 PIK38991.1 - 0.074 13.4 0.0 0.098 13.0 0.0 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Amnionless PF14828.6 PIK38991.1 - 0.081 11.7 0.0 0.089 11.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless V-set PF07686.17 PIK38992.1 - 8.7e-11 42.0 2.1 2e-05 24.7 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK38992.1 - 1.2e-06 28.6 0.8 0.044 14.0 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.6 PIK38992.1 - 2.3e-06 28.1 6.2 0.36 11.5 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.5 PIK38992.1 - 0.11 12.9 1.2 0.44 11.0 0.3 2.4 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Zip PF02535.22 PIK38993.1 - 7.9e-59 199.5 12.8 7.9e-59 199.5 12.8 2.5 2 1 0 2 2 2 2 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK38993.1 - 6.3e-13 49.0 4.7 7.8e-11 42.2 0.2 2.4 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain DUF456 PF04306.13 PIK38993.1 - 3.7 7.8 13.2 0.095 13.0 3.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF456) Sulfatase PF00884.23 PIK38994.1 - 2.1e-60 204.7 0.9 2.6e-60 204.4 0.9 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK38994.1 - 0.00031 20.4 1.8 0.0054 16.4 1.8 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Engrail_1_C_sig PF10525.9 PIK38994.1 - 0.038 13.2 0.1 0.081 12.2 0.1 1.5 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain zf-CCHC PF00098.23 PIK38995.1 - 1.9e-05 24.5 1.2 2.7e-05 24.0 1.2 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK38995.1 - 0.0017 18.0 1.6 0.0034 17.1 1.6 1.5 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK38995.1 - 0.011 15.7 0.4 0.02 14.8 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle BAR_3 PF16746.5 PIK38995.1 - 0.03 14.0 0.1 0.036 13.8 0.1 1.2 1 0 0 1 1 1 0 BAR domain of APPL family zf-CCHC_2 PF13696.6 PIK38995.1 - 0.058 13.2 3.2 0.087 12.7 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-C2HE PF16278.5 PIK38995.1 - 0.075 13.5 0.3 0.15 12.5 0.3 1.7 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger RVT_1 PF00078.27 PIK38996.1 - 1.4e-10 41.0 0.0 1e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Radical_SAM PF04055.21 PIK38996.1 - 0.097 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily RVT_1 PF00078.27 PIK38997.1 - 9.9e-33 113.5 0.3 6e-32 111.0 0.2 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Radical_SAM PF04055.21 PIK38997.1 - 0.18 12.2 0.0 0.55 10.6 0.0 1.8 1 0 0 1 1 1 0 Radical SAM superfamily rve PF00665.26 PIK38998.1 - 1e-24 87.0 0.0 1.4e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK38998.1 - 2.9e-19 68.9 3.2 4.7e-19 68.2 3.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK38998.1 - 4.4e-05 23.2 0.0 0.00012 21.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK38998.1 - 0.00017 21.8 0.8 0.00033 20.8 0.8 1.5 1 0 0 1 1 1 1 H2C2 zinc finger HMG_box PF00505.19 PIK38999.1 - 1.2e-27 96.1 10.2 3.2e-14 53.1 1.5 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK38999.1 - 6.5e-24 84.3 12.8 7.4e-14 52.1 3.5 2.4 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.6 PIK38999.1 - 0.028 14.4 1.6 0.028 14.4 1.6 2.3 1 1 1 2 2 2 0 HMG (high mobility group) box 5 NigD_N PF12667.7 PIK39000.1 - 6.4e-08 32.6 0.0 6.4 7.0 0.0 6.2 3 1 4 7 7 7 4 NigD-like N-terminal OB domain zf-C4_Topoisom PF01396.19 PIK39000.1 - 3.6e-06 26.7 4.4 30 4.5 0.0 6.8 7 0 0 7 7 7 1 Topoisomerase DNA binding C4 zinc finger bPH_6 PF10756.9 PIK39000.1 - 0.0015 18.5 2.8 15 5.8 0.1 3.8 2 1 2 4 4 4 3 Bacterial PH domain EIAV_Rev PF11129.8 PIK39000.1 - 0.023 14.9 11.5 2 8.6 0.9 3.8 1 1 3 4 4 4 0 Rev protein of equine infectious anaemia virus DUF1391 PF07151.12 PIK39000.1 - 3.9 7.4 6.0 6.9 6.6 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1391) Capsid_VP7 PF17071.5 PIK39002.1 - 0.43 9.8 3.5 0.49 9.6 3.5 1.1 1 0 0 1 1 1 0 Outer capsid protein VP7 GRIP PF01465.20 PIK39003.1 - 3.4e-16 58.9 0.4 1.5e-15 56.8 0.4 2.3 1 0 0 1 1 1 1 GRIP domain Rab_bind PF16704.5 PIK39003.1 - 3.7e-10 39.7 7.0 3.7e-10 39.7 7.0 4.8 5 1 1 6 6 6 1 Rab binding domain SlyX PF04102.12 PIK39003.1 - 0.00082 20.0 5.4 0.00082 20.0 5.4 7.5 3 2 3 7 7 7 2 SlyX Bap31_Bap29_C PF18035.1 PIK39003.1 - 0.01 15.8 9.0 0.01 15.8 9.0 7.7 5 3 1 6 6 6 0 Bap31/Bap29 cytoplasmic coiled-coil domain DASH_Dam1 PF08653.10 PIK39003.1 - 4.6 7.1 6.8 22 5.0 0.1 3.7 3 0 0 3 3 3 0 DASH complex subunit Dam1 Spc7 PF08317.11 PIK39004.1 - 0.0048 15.8 24.5 0.0048 15.8 24.5 7.2 1 1 7 8 8 8 4 Spc7 kinetochore protein TACC_C PF05010.14 PIK39004.1 - 0.01 15.7 27.6 0.01 15.7 27.6 7.2 1 1 6 7 7 7 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ATG16 PF08614.11 PIK39004.1 - 0.015 15.5 15.1 0.015 15.5 15.1 7.3 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 PIK39004.1 - 0.017 15.7 29.9 0.017 15.7 29.9 9.2 1 1 8 9 9 9 0 Apg6 coiled-coil region Fez1 PF06818.15 PIK39004.1 - 0.018 15.5 156.7 0.23 11.9 37.4 6.4 1 1 5 6 6 6 0 Fez1 Filament PF00038.21 PIK39004.1 - 0.022 14.3 145.5 0.47 10.0 52.9 5.3 1 1 3 4 4 4 0 Intermediate filament protein GAS PF13851.6 PIK39004.1 - 0.26 10.6 176.3 0.5 9.7 24.7 7.9 1 1 7 8 8 8 0 Growth-arrest specific micro-tubule binding MscS_porin PF12795.7 PIK39004.1 - 1.8 8.0 132.4 0.27 10.8 18.6 6.0 1 1 5 6 6 6 0 Mechanosensitive ion channel porin domain HALZ PF02183.18 PIK39005.1 - 0.052 13.8 18.8 0.1 12.8 0.1 4.9 2 2 3 5 5 5 0 Homeobox associated leucine zipper Spc7 PF08317.11 PIK39005.1 - 0.14 11.0 32.5 1 8.2 2.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 PIK39005.1 - 0.22 10.9 30.4 0.38 10.1 15.4 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF724 PF05266.14 PIK39005.1 - 0.38 10.6 27.1 1.6 8.5 13.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 PIK39005.1 - 0.51 10.8 21.4 5.6 7.4 4.6 4.0 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF2009 PF09418.10 PIK39005.1 - 0.82 8.7 11.2 0.39 9.7 9.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2009) TPR_MLP1_2 PF07926.12 PIK39005.1 - 1.6 8.8 36.1 0.43 10.6 27.0 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.6 PIK39005.1 - 1.9 8.4 32.3 0.87 9.6 21.1 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Uso1_p115_C PF04871.13 PIK39005.1 - 2.7 8.4 31.7 0.47 10.8 13.6 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 PIK39005.1 - 3.5 8.2 34.0 5 7.7 25.9 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 PIK39005.1 - 3.9 7.5 20.4 0.14 12.2 7.7 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 PIK39005.1 - 4.5 7.7 29.1 5.6 7.4 15.7 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Vir_act_alpha_C PF10400.9 PIK39005.1 - 5 7.9 9.6 38 5.0 0.2 3.0 1 1 1 2 2 2 0 Virulence activator alpha C-term Atg14 PF10186.9 PIK39005.1 - 5.1 6.1 22.2 8.6 5.3 22.2 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 PIK39005.1 - 5.2 7.8 25.1 1.8e+04 -7.5 25.1 3.0 1 1 0 1 1 0 0 Initiation control protein YabA CorA PF01544.18 PIK39005.1 - 6.8 5.9 11.0 9.5 5.4 9.7 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Seryl_tRNA_N PF02403.22 PIK39005.1 - 7.1 6.9 26.5 1.7 8.9 16.0 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF2509 PF10713.9 PIK39005.1 - 7.2 6.7 10.1 1.3 9.1 6.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2509) DUF730 PF05325.11 PIK39005.1 - 8.4 6.4 11.5 4.8 7.2 2.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF730) KxDL PF10241.9 PIK39005.1 - 9.4 6.6 22.1 0.45 10.8 0.6 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein Folate_carrier PF01770.18 PIK39006.1 - 1.3e-109 366.8 21.2 1.1e-90 304.4 10.7 2.9 1 1 1 2 2 2 2 Reduced folate carrier HR1 PF02185.16 PIK39006.1 - 0.0016 18.5 1.6 29 4.9 0.0 4.5 4 1 0 4 4 4 3 Hr1 repeat Glyco_transf_8 PF01501.20 PIK39007.1 - 1.6e-19 70.5 0.0 6e-17 62.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 PIK39007.1 - 0.00031 20.2 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 PIK39007.1 - 0.013 15.5 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase WW PF00397.26 PIK39008.1 - 7.9e-09 35.5 0.5 1.5e-08 34.6 0.5 1.5 1 0 0 1 1 1 1 WW domain KIND PF16474.5 PIK39009.1 - 3.9e-33 115.0 2.5 6.4e-33 114.3 1.3 2.0 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain FYVE PF01363.21 PIK39009.1 - 2e-07 31.0 7.3 2e-07 31.0 7.3 2.4 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 PIK39009.1 - 0.0026 17.9 5.5 0.0026 17.9 5.5 2.8 3 1 0 3 3 3 1 FYVE-type zinc finger DUF4874 PF16173.5 PIK39009.1 - 0.12 12.0 0.2 12 5.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) DUF745 PF05335.13 PIK39009.1 - 0.23 11.1 1.3 0.42 10.3 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) MARVEL PF01284.23 PIK39010.1 - 8.2e-07 29.1 19.4 1.5e-06 28.3 19.3 1.3 1 1 0 1 1 1 1 Membrane-associating domain MitMem_reg PF13012.6 PIK39011.1 - 2.3e-35 121.4 0.4 4.2e-35 120.6 0.4 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 PIK39011.1 - 4.2e-33 113.8 0.0 1.1e-32 112.4 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CobT PF06213.12 PIK39011.1 - 0.087 12.2 14.7 0.12 11.7 14.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 PIK39011.1 - 0.087 13.3 9.7 0.15 12.5 9.7 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 PIK39011.1 - 0.4 9.6 1.9 0.56 9.1 1.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 PIK39011.1 - 0.62 10.2 12.1 1.3 9.1 12.1 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 PIK39011.1 - 1 8.3 6.3 1.5 7.7 6.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 PIK39011.1 - 1.2 7.5 2.7 1.5 7.2 2.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 PIK39011.1 - 1.3 6.9 8.0 1.7 6.4 8.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 PIK39011.1 - 2.4 7.8 12.9 6.9 6.3 12.9 1.8 1 1 0 1 1 1 0 Connexin O-antigen_lig PF13425.6 PIK39011.1 - 2.5 6.8 7.4 3.4 6.3 7.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 PIK39011.1 - 3.4 6.3 11.3 4.3 6.0 11.3 1.1 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 PIK39011.1 - 5.8 7.0 6.3 10 6.1 6.3 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region SRCR PF00530.18 PIK39012.1 - 4.2e-17 62.5 0.5 1.4e-08 35.2 0.2 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK39012.1 - 0.00024 21.5 1.8 0.0059 17.1 0.1 2.4 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain Pkinase_Tyr PF07714.17 PIK39013.1 - 1.3e-25 90.2 0.0 1.6e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39013.1 - 1.4e-24 86.9 0.0 1.8e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PNP_UDP_1 PF01048.20 PIK39014.1 - 4e-51 173.5 0.1 4.6e-51 173.3 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily LBP_BPI_CETP_C PF02886.17 PIK39015.1 - 5.3e-28 98.1 0.3 8.6e-28 97.4 0.3 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP_C PF02886.17 PIK39016.1 - 7.6e-33 113.9 0.9 2.7e-28 99.1 0.6 2.4 2 0 0 2 2 2 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK39016.1 - 2.7e-25 88.9 0.0 4.9e-25 88.0 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Rtt106 PF08512.12 PIK39016.1 - 0.031 14.7 0.1 0.073 13.5 0.1 1.6 1 0 0 1 1 1 0 Histone chaperone Rttp106-like DUF680 PF05079.12 PIK39017.1 - 0.18 12.5 2.0 0.41 11.4 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF680) DUF3446 PF11928.8 PIK39017.1 - 2.7 8.4 14.2 0.93 9.8 4.7 2.9 2 0 0 2 2 2 0 Early growth response N-terminal domain zinc_ribbon_4 PF13717.6 PIK39018.1 - 0.00023 21.0 1.8 0.01 15.7 0.2 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 PIK39018.1 - 0.0036 16.7 0.7 1.6 8.2 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain SelR PF01641.18 PIK39018.1 - 0.016 15.3 0.1 0.026 14.6 0.1 1.3 1 1 0 1 1 1 0 SelR domain Yippee-Mis18 PF03226.14 PIK39018.1 - 0.017 15.3 0.5 0.044 14.0 0.5 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-RING_7 PF02591.15 PIK39018.1 - 0.023 14.9 1.2 0.027 14.7 0.1 1.8 2 0 0 2 2 2 0 C4-type zinc ribbon domain zinc_ribbon_5 PF13719.6 PIK39018.1 - 0.026 14.3 1.9 0.28 11.0 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF4107 PF13389.6 PIK39018.1 - 0.041 14.0 0.0 0.048 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4107) Elf1 PF05129.13 PIK39018.1 - 0.064 13.3 0.1 11 6.2 0.0 2.1 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like HECT_2 PF09814.9 PIK39018.1 - 0.065 12.1 0.1 0.065 12.1 0.1 1.5 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Ribosomal_L38e PF01781.18 PIK39019.1 - 3.5e-35 119.9 2.3 3.8e-35 119.8 2.3 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family RRM_1 PF00076.22 PIK39020.1 - 4.1e-12 45.8 0.0 8.3e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 PIK39020.1 - 0.012 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) U-box PF04564.15 PIK39021.1 - 2.1e-30 104.7 0.2 1.2e-29 102.3 0.1 2.5 2 0 0 2 2 2 1 U-box domain CHIP_TPR_N PF18391.1 PIK39021.1 - 5.9e-21 75.0 9.5 1.6e-20 73.6 9.5 1.8 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_1 PF00515.28 PIK39021.1 - 3.1e-14 52.1 1.8 0.00027 20.6 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39021.1 - 4.7e-12 45.0 1.1 4.8e-05 23.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39021.1 - 3.4e-10 39.4 0.1 3.7e-07 29.7 0.0 3.9 3 1 1 4 4 4 1 TPR repeat TPR_16 PF13432.6 PIK39021.1 - 3.8e-06 27.4 0.0 0.0039 17.8 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39021.1 - 4.7e-05 23.6 0.7 0.023 15.0 0.2 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39021.1 - 0.0002 21.1 0.9 0.12 12.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39021.1 - 0.00026 21.0 2.6 0.77 10.1 0.2 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK39021.1 - 0.00051 20.2 1.5 0.00093 19.4 0.7 2.0 2 0 0 2 2 1 1 Anaphase-promoting complex, cyclosome, subunit 3 zf-NOSIP PF15906.5 PIK39021.1 - 0.0034 17.5 0.1 0.064 13.4 0.0 2.8 3 0 0 3 3 3 1 Zinc-finger of nitric oxide synthase-interacting protein NRBF2_MIT PF17169.4 PIK39021.1 - 0.0037 17.5 0.1 0.017 15.4 0.0 2.2 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 TPR_19 PF14559.6 PIK39021.1 - 0.0055 17.2 0.1 0.19 12.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39021.1 - 0.018 15.8 0.0 1.4 10.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK39021.1 - 0.056 13.8 0.0 1.5 9.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 PIK39021.1 - 0.56 10.3 3.3 1.4 9.0 0.2 3.0 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain PH PF00169.29 PIK39022.1 - 0.19 12.2 0.0 0.79 10.3 0.0 2.0 2 1 0 2 2 2 0 PH domain RhoGEF PF00621.20 PIK39023.1 - 5.4e-16 59.4 0.0 8.7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain DUF3288 PF11691.8 PIK39023.1 - 0.13 12.3 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3288) CUB PF00431.20 PIK39024.1 - 7.3e-11 42.4 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 CUB domain RRM_1 PF00076.22 PIK39025.1 - 5.5e-19 67.8 0.0 9.3e-19 67.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 PIK39025.1 - 1.3e-11 44.9 0.4 1.3e-11 44.9 0.4 3.3 3 1 0 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_7 PF16367.5 PIK39025.1 - 0.079 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif DUF4470 PF14737.6 PIK39026.1 - 0.018 15.2 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) Phage_integrase PF00589.22 PIK39027.1 - 0.0047 16.7 0.0 0.011 15.6 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family HTH_Tnp_Mu_2 PF09039.11 PIK39028.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain 7tm_1 PF00001.21 PIK39029.1 - 6.9e-26 91.1 17.2 6.9e-26 91.1 17.2 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK39029.1 - 1.7e-07 30.9 24.3 2.4e-07 30.4 24.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK39029.1 - 2.2e-05 24.2 24.8 6.7e-05 22.6 24.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39029.1 - 2.9e-05 23.6 22.9 0.00093 18.7 22.9 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF782 PF05614.11 PIK39029.1 - 0.12 12.8 1.2 0.24 11.8 0.2 1.9 2 0 0 2 2 2 0 Circovirus protein of unknown function (DUF782) DUF809 PF05663.11 PIK39029.1 - 0.74 9.9 2.2 0.86 9.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF809) ECSCR PF15820.5 PIK39029.1 - 3.8 7.4 8.3 0.12 12.2 0.9 2.3 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Ldh_2 PF02615.14 PIK39030.1 - 3.7e-50 171.0 0.4 3.5e-49 167.7 0.4 1.9 1 1 0 1 1 1 1 Malate/L-lactate dehydrogenase TRIC PF05197.13 PIK39031.1 - 2.3e-65 219.8 4.1 2.7e-65 219.5 4.1 1.1 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 PIK39031.1 - 0.0013 18.6 3.4 0.006 16.5 0.3 2.3 2 0 0 2 2 2 1 UPF0126 domain FGGY_C PF02782.16 PIK39032.1 - 2.1e-49 167.9 0.1 3.5e-49 167.2 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 PIK39032.1 - 9.6e-27 94.1 0.9 2.9e-26 92.5 0.3 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain ALS2CR8 PF15299.6 PIK39032.1 - 1.2e-14 54.8 0.3 1.9e-14 54.1 0.3 1.3 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 FAR1 PF03101.15 PIK39032.1 - 0.015 16.0 0.3 0.039 14.6 0.3 1.7 1 0 0 1 1 1 0 FAR1 DNA-binding domain Y_phosphatase PF00102.27 PIK39033.1 - 6.5e-36 124.1 0.0 8e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CbiK PF06180.11 PIK39033.1 - 0.1 11.9 0.0 7.3 5.8 0.0 2.1 2 0 0 2 2 2 0 Cobalt chelatase (CbiK) VWD PF00094.25 PIK39034.1 - 4.7e-12 46.4 2.6 4.5e-06 27.0 0.5 2.7 2 0 0 2 2 2 2 von Willebrand factor type D domain DUF1943 PF09172.11 PIK39034.1 - 1.2e-08 34.6 0.0 3.9e-08 32.9 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) DUF1676 PF07898.13 PIK39034.1 - 0.013 15.6 0.0 0.046 13.8 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DUF5578 PF17741.1 PIK39035.1 - 2e-122 407.8 5.1 2e-122 407.8 5.1 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5578) Vitellogenin_N PF01347.22 PIK39035.1 - 9e-77 258.9 1.6 1.6e-76 258.1 1.6 1.3 1 0 0 1 1 1 1 Lipoprotein amino terminal region HEAT_2 PF13646.6 PIK39035.1 - 9.7e-05 22.7 0.0 0.069 13.5 0.0 3.4 2 1 1 3 3 3 1 HEAT repeats Arm PF00514.23 PIK39035.1 - 0.00023 21.1 0.4 0.21 11.7 0.0 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat FliG_N PF14842.6 PIK39035.1 - 0.0096 16.5 0.4 0.044 14.3 0.4 2.2 1 0 0 1 1 1 1 FliG N-terminal domain DUF1827 PF08860.10 PIK39035.1 - 0.18 12.1 0.9 0.67 10.2 0.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) UBX PF00789.20 PIK39036.1 - 1.9e-17 63.2 0.0 2.6e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 UBX domain SEP PF08059.13 PIK39036.1 - 1.2e-06 29.0 0.1 1.9e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 SEP domain Cnd1_N PF12922.7 PIK39036.1 - 0.0074 16.2 0.1 0.0098 15.8 0.1 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term zf-H2C2_5 PF13909.6 PIK39038.1 - 9.9e-05 22.0 2.3 9.9e-05 22.0 2.3 1.9 2 0 0 2 2 2 1 C2H2-type zinc-finger domain Ntox28 PF15605.6 PIK39038.1 - 0.072 13.3 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial toxin 28 zf-C2H2 PF00096.26 PIK39038.1 - 0.08 13.4 0.9 0.08 13.4 0.9 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK39038.1 - 0.095 13.2 0.7 0.095 13.2 0.7 2.5 3 0 0 3 3 3 0 Zinc-finger double domain Zn_Tnp_IS1595 PF12760.7 PIK39038.1 - 0.15 12.1 1.1 0.37 10.8 1.1 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Actin_micro PF17003.5 PIK39038.1 - 0.23 10.6 1.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 Putative actin-like family rve PF00665.26 PIK39039.1 - 3.3e-24 85.3 0.0 4.8e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK39039.1 - 2.9e-11 43.3 5.8 1.1e-10 41.4 0.9 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK39039.1 - 0.0033 17.2 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK39039.1 - 0.0056 16.9 0.9 0.0056 16.9 0.9 2.0 2 0 0 2 2 2 1 H2C2 zinc finger MycE_N PF17843.1 PIK39039.1 - 0.01 16.3 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal QueC PF06508.13 PIK39039.1 - 0.11 11.9 0.7 0.21 11.1 0.6 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC RT_RNaseH_2 PF17919.1 PIK39040.1 - 2.5e-37 126.9 0.1 5.3e-37 125.9 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK39040.1 - 1.5e-33 115.2 0.1 2.9e-33 114.3 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39040.1 - 4.5e-31 108.1 0.0 7.2e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK39041.1 - 8.6e-08 31.9 1.9 1.7e-07 31.0 1.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK39041.1 - 0.00027 20.7 0.1 0.00027 20.7 0.1 1.9 2 0 0 2 2 2 1 Zinc knuckle PNMA PF14893.6 PIK39041.1 - 0.013 14.9 1.3 0.021 14.2 0.6 1.7 1 1 1 2 2 2 0 PNMA zf-C2H2_10 PF16588.5 PIK39041.1 - 0.095 12.4 0.4 0.15 11.8 0.4 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK39041.1 - 0.12 12.5 0.3 0.31 11.2 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK39041.1 - 0.17 11.7 0.5 0.37 10.5 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle HscB_4_cys PF18256.1 PIK39041.1 - 6.9 6.6 5.9 0.85 9.5 1.1 2.0 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Pkinase PF00069.25 PIK39042.1 - 3.5e-32 111.8 0.0 5.6e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39042.1 - 2.4e-18 66.3 0.0 3.4e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK39042.1 - 0.0003 20.2 0.0 0.00059 19.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK39042.1 - 0.026 14.1 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 RIO1 family TAF4 PF05236.14 PIK39042.1 - 0.044 13.5 1.7 0.065 13.0 1.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family APH PF01636.23 PIK39042.1 - 0.052 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK39042.1 - 0.089 11.8 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PAP1 PF08601.10 PIK39042.1 - 3.8 7.1 10.3 5.5 6.6 10.3 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Pkinase PF00069.25 PIK39043.1 - 1.3e-21 77.2 0.0 1.9e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39043.1 - 7e-09 35.3 0.0 9.1e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 PIK39043.1 - 0.0068 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK39043.1 - 0.048 13.6 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK39043.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 PIK39044.1 - 8.2e-29 100.8 0.0 9.7e-27 94.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39044.1 - 1.6e-13 50.5 0.0 3.8e-12 46.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK39044.1 - 0.00025 20.5 0.0 0.00043 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK39044.1 - 0.024 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 PIK39044.1 - 0.033 14.1 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK39044.1 - 0.084 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 PIK39044.1 - 0.12 11.7 0.0 0.84 8.9 0.0 1.9 1 1 0 1 1 1 0 Kinase-like ZU5 PF00791.20 PIK39045.1 - 2.3e-10 40.7 0.1 8.7e-10 38.8 0.1 2.0 1 0 0 1 1 1 1 ZU5 domain Homez PF11569.8 PIK39045.1 - 0.0011 18.4 0.9 2.1 7.9 0.0 3.4 3 0 0 3 3 3 2 Homeodomain leucine-zipper encoding, Homez F-box PF00646.33 PIK39045.1 - 0.025 14.5 0.7 2.5 8.1 0.0 3.1 3 0 0 3 3 3 0 F-box domain cNMPbd_u2 PF16643.5 PIK39045.1 - 0.48 10.9 4.8 15 6.0 0.0 3.1 3 0 0 3 3 3 0 Unstructured region on cNMP-binding protein DUF2987 PF11205.8 PIK39045.1 - 1.1 9.1 7.8 2.3 8.1 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2987) ATG16 PF08614.11 PIK39045.1 - 2.6 8.2 36.1 0.12 12.6 27.7 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) GCFC PF07842.12 PIK39046.1 - 0.075 12.6 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein FKBP_C PF00254.28 PIK39047.1 - 7.6e-19 67.8 0.1 2.7e-18 66.0 0.0 2.0 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 PIK39047.1 - 6.4e-09 35.3 2.1 0.0065 16.5 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39047.1 - 3.8e-07 29.6 3.2 0.008 16.0 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39047.1 - 4.4e-05 23.1 1.8 0.19 11.4 0.3 3.0 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 PIK39047.1 - 0.0021 18.5 2.3 0.18 12.3 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39047.1 - 0.0026 18.4 0.9 0.16 12.9 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39047.1 - 0.0036 17.4 1.5 4 7.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat R3H PF01424.22 PIK39047.1 - 0.03 14.3 1.4 0.12 12.4 0.2 2.4 2 0 0 2 2 2 0 R3H domain TPR_17 PF13431.6 PIK39047.1 - 0.14 12.6 0.1 0.84 10.2 0.1 2.3 1 1 0 1 1 1 0 Tetratricopeptide repeat tRNA_U5-meth_tr PF05958.11 PIK39048.1 - 1.9e-15 56.7 0.0 5.2e-15 55.3 0.0 1.7 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 PIK39048.1 - 3.2e-10 40.0 0.0 7.2e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39048.1 - 1.1e-08 35.6 0.1 3e-08 34.3 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK39048.1 - 1.7e-06 27.6 0.1 4e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 PIK39048.1 - 4.8e-06 26.2 0.1 8.5e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 PIK39048.1 - 7e-06 26.6 0.0 1.8e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39048.1 - 2.5e-05 23.8 0.1 4.7e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 PIK39048.1 - 0.00026 20.6 0.1 0.00044 19.9 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 PIK39048.1 - 0.00029 20.7 0.0 0.0005 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 PIK39048.1 - 0.0003 20.3 0.2 0.00062 19.3 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK39048.1 - 0.00086 19.3 0.6 0.0025 17.8 0.1 2.0 2 0 0 2 2 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK39048.1 - 0.00089 18.9 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 PIK39048.1 - 0.002 18.0 0.0 0.0036 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 PIK39048.1 - 0.0043 17.1 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 PIK39048.1 - 0.02 14.6 1.1 0.19 11.4 1.1 2.2 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 TPMT PF05724.11 PIK39048.1 - 0.039 13.6 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DnaI_N PF07319.11 PIK39048.1 - 0.049 14.3 0.0 0.17 12.6 0.0 1.9 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus RVT_2 PF07727.14 PIK39049.1 - 2.2e-12 47.2 0.1 2.8e-12 46.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MULE PF10551.9 PIK39051.1 - 0.018 15.4 0.7 0.047 14.1 0.7 1.7 1 0 0 1 1 1 0 MULE transposase domain wnt PF00110.19 PIK39054.1 - 0.072 12.7 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 wnt family RE_AlwI PF09491.10 PIK39054.1 - 0.083 11.7 2.5 0.12 11.1 2.5 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease RsbU_N PF08673.10 PIK39054.1 - 0.22 11.6 1.2 3.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain ZU5 PF00791.20 PIK39055.1 - 4e-09 36.7 0.0 8.6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain ZU5 PF00791.20 PIK39056.1 - 0.00018 21.8 0.0 0.00054 20.2 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain Ank_4 PF13637.6 PIK39056.1 - 0.00051 20.6 0.0 25 5.6 0.0 4.1 4 0 0 4 4 4 0 Ankyrin repeats (many copies) APG6_N PF17675.1 PIK39056.1 - 0.00099 19.6 67.9 0.071 13.6 37.7 3.3 1 1 3 4 4 4 4 Apg6 coiled-coil region ERM PF00769.19 PIK39056.1 - 0.00099 19.0 38.9 0.00099 19.0 38.9 2.3 1 1 1 2 2 2 1 Ezrin/radixin/moesin family KASH_CCD PF14662.6 PIK39056.1 - 0.058 13.2 67.9 0.33 10.7 15.6 3.7 2 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 PIK39056.1 - 0.99 8.7 65.7 0.55 9.6 22.6 3.8 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding TACC_C PF05010.14 PIK39056.1 - 1.2 8.9 53.6 0.54 10.0 27.0 2.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1374 PF07118.11 PIK39056.1 - 3.6 8.2 13.0 35 5.0 0.1 5.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1374) DUF4976 PF16347.5 PIK39057.1 - 0.032 14.5 1.1 8.8 6.7 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4976) COQ7 PF03232.13 PIK39058.1 - 3.6e-75 251.5 0.0 4.3e-75 251.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 PIK39058.1 - 0.00027 21.4 0.2 0.00071 20.0 0.2 1.6 1 1 0 1 1 1 1 Rubrerythrin DUF4145 PF13643.6 PIK39058.1 - 0.055 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) Ferritin_2 PF13668.6 PIK39058.1 - 0.065 13.4 0.2 1.6 8.9 0.0 2.2 1 1 1 2 2 2 0 Ferritin-like domain Sec7 PF01369.20 PIK39059.1 - 1.9e-71 239.6 0.0 2.5e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 PIK39059.1 - 1.4e-25 89.8 0.3 2.5e-25 89.0 0.3 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK39059.1 - 1.4e-07 31.9 1.7 6.9e-07 29.7 1.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 PIK39059.1 - 0.0024 18.0 0.0 0.0063 16.6 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 PIK39059.1 - 0.017 15.4 0.1 0.12 12.7 0.0 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain YjbT PF17089.5 PIK39059.1 - 0.16 12.0 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family Methyltransf_11 PF08241.12 PIK39060.1 - 1.2e-11 45.1 0.0 2.1e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39060.1 - 3.7e-11 43.6 0.0 7.8e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK39060.1 - 3.6e-10 39.8 0.2 1.1e-09 38.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39060.1 - 0.00018 22.2 0.0 0.00037 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK39060.1 - 0.04 13.3 0.0 0.068 12.6 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Sulfotransfer_2 PF03567.14 PIK39061.1 - 2.9e-12 47.0 3.9 7.4e-12 45.7 3.9 1.7 1 0 0 1 1 1 1 Sulfotransferase family DDE_3 PF13358.6 PIK39062.1 - 0.13 12.0 0.6 2.8 7.7 0.0 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease Exo_endo_phos_2 PF14529.6 PIK39063.1 - 5.7e-08 32.6 0.0 9e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK39063.1 - 0.0058 16.2 0.0 0.0099 15.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Methyltransf_31 PF13847.6 PIK39064.1 - 2.3e-08 34.0 0.1 0.00017 21.5 0.1 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39064.1 - 1.1e-05 26.1 0.1 0.073 13.8 0.0 2.9 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39064.1 - 1.8e-05 25.4 0.1 0.0036 18.0 0.1 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39064.1 - 6.8e-05 22.8 0.0 0.052 13.4 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39064.1 - 0.00013 22.5 0.0 0.43 11.2 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 PIK39064.1 - 0.00086 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK39064.1 - 0.01 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.18 PIK39064.1 - 0.047 13.0 0.1 0.24 10.7 0.0 2.0 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 PIK39064.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK39065.1 - 4.1e-25 88.3 0.0 5.8e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39065.1 - 2.5e-17 63.4 0.0 5.1e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39065.1 - 5e-17 62.3 0.0 8.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39065.1 - 1.3e-13 51.2 0.0 1.9e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39065.1 - 1.6e-13 51.3 0.0 2.9e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39065.1 - 6.8e-09 35.4 0.0 9.2e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 PIK39065.1 - 2.2e-08 33.7 0.0 3.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 PIK39065.1 - 3.3e-06 26.6 0.0 4.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 PIK39065.1 - 3.4e-05 23.5 0.0 5.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 PIK39065.1 - 6.5e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK39065.1 - 0.00013 21.3 0.0 0.00019 20.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK39065.1 - 0.00082 19.2 0.0 0.0016 18.2 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 PIK39065.1 - 0.0025 17.3 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 PIK39065.1 - 0.0038 17.2 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 PIK39065.1 - 0.037 13.6 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW NodS PF05401.11 PIK39065.1 - 0.039 13.6 0.0 0.06 13.0 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Dimerisation2 PF16864.5 PIK39065.1 - 0.051 13.6 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 Dimerisation domain RrnaAD PF00398.20 PIK39065.1 - 0.22 10.6 0.0 0.3 10.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Sulfotransfer_2 PF03567.14 PIK39066.1 - 5e-13 49.6 1.1 1e-12 48.5 1.1 1.5 1 1 0 1 1 1 1 Sulfotransferase family Arm PF00514.23 PIK39067.1 - 2.3e-09 37.0 3.0 0.011 15.8 0.2 5.7 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 PIK39067.1 - 1.6e-06 28.1 1.1 0.00095 19.1 0.1 4.2 2 1 2 4 4 4 1 Spinocerebellar ataxia type 10 protein domain LON_substr_bdg PF02190.16 PIK39067.1 - 0.1 12.4 1.0 0.2 11.5 1.0 1.5 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain ARTD15_N PF18084.1 PIK39068.1 - 1.1e-26 92.9 0.1 2.6e-26 91.7 0.1 1.7 1 0 0 1 1 1 1 ARTD15 N-terminal domain PARP PF00644.20 PIK39068.1 - 2.7e-24 85.8 0.2 1.4e-23 83.5 0.2 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ArlS_N PF18719.1 PIK39068.1 - 0.064 13.5 0.1 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 ArlS sensor domain COX7a PF02238.15 PIK39068.1 - 0.09 13.2 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII Exotox-A_cataly PF09009.10 PIK39068.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A catalytic TB2_DP1_HVA22 PF03134.19 PIK39070.1 - 0.0021 18.0 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RNA_GG_bind PF10258.9 PIK39073.1 - 2e-27 95.1 0.0 4.5e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain Y_phosphatase PF00102.27 PIK39074.1 - 1.9e-27 96.4 0.4 2e-13 50.5 0.0 2.3 1 1 1 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK39074.1 - 1.6e-17 63.6 2.7 1e-05 25.8 0.1 3.6 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK39074.1 - 0.00062 20.3 5.4 0.061 13.9 0.0 4.0 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain CD34_antigen PF06365.12 PIK39074.1 - 0.0034 17.0 0.0 0.021 14.4 0.0 2.0 2 0 0 2 2 2 1 CD34/Podocalyxin family DSPc PF00782.20 PIK39074.1 - 0.015 15.1 0.1 0.032 14.0 0.1 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain fn3_2 PF16893.5 PIK39074.1 - 0.016 15.3 0.0 0.1 12.7 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain PhoR PF11808.8 PIK39074.1 - 0.24 11.8 0.3 1.8 9.0 0.3 2.2 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR GCFC PF07842.12 PIK39075.1 - 0.062 12.9 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein Arteri_env PF01606.16 PIK39076.1 - 0.034 14.0 4.7 0.047 13.5 4.7 1.2 1 0 0 1 1 1 0 Arterivirus envelope protein Pkinase_Tyr PF07714.17 PIK39077.1 - 1.3e-21 77.1 0.0 1.7e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39077.1 - 1.2e-20 73.9 0.0 1.7e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain YorP PF09629.10 PIK39077.1 - 0.074 13.3 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 YorP protein RVT_1 PF00078.27 PIK39078.1 - 3.2e-26 92.2 0.4 4.5e-26 91.7 0.4 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK39079.1 - 6.5e-21 74.9 0.1 9.7e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CD225 PF04505.12 PIK39080.1 - 5e-24 84.2 1.5 6.5e-24 83.8 1.5 1.1 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF2852 PF11014.8 PIK39080.1 - 0.042 14.0 0.1 0.051 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) DUF4190 PF13828.6 PIK39080.1 - 0.77 9.6 9.1 3.9 7.3 9.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4190) TruD PF01142.18 PIK39081.1 - 2.3e-20 72.8 0.0 3.7e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) TruD PF01142.18 PIK39082.1 - 5.5e-16 58.4 0.1 3.8e-11 42.5 0.2 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DUF4486 PF14858.6 PIK39083.1 - 2.4e-109 366.3 6.0 3e-109 366.0 6.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4486) DUF4486 PF14858.6 PIK39084.1 - 1.6e-31 109.4 0.0 2.8e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4486) fn3 PF00041.21 PIK39085.1 - 0.00058 20.1 0.0 0.073 13.4 0.0 2.4 2 0 0 2 2 2 2 Fibronectin type III domain TPR_2 PF07719.17 PIK39086.1 - 0.023 14.8 0.0 0.08 13.1 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39086.1 - 0.11 12.8 0.0 0.42 10.9 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ORC6 PF05460.13 PIK39087.1 - 0.69 9.1 4.7 3.5 6.8 0.5 2.2 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) UCH PF00443.29 PIK39089.1 - 1.4e-39 136.1 5.3 1.4e-39 136.1 5.3 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK39089.1 - 1.3e-23 84.1 4.2 3.1e-14 53.3 0.7 2.7 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUF2625 PF10946.8 PIK39089.1 - 0.038 13.1 0.0 0.068 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 RHD_DNA_bind PF00554.22 PIK39089.1 - 0.16 11.9 0.4 0.34 10.8 0.4 1.5 1 0 0 1 1 1 0 Rel homology DNA-binding domain Fae PF08714.11 PIK39091.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Formaldehyde-activating enzyme (Fae) Nucleos_tra2_N PF01773.20 PIK39093.1 - 3.8e-27 94.7 2.6 3.8e-27 94.7 2.6 2.2 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 PIK39093.1 - 1.7e-05 25.1 1.7 4e-05 23.9 0.2 2.3 2 0 0 2 2 2 1 Nucleoside recognition E1-E2_ATPase PF00122.20 PIK39093.1 - 0.098 12.2 0.5 5.1 6.6 0.0 2.4 2 0 0 2 2 2 0 E1-E2 ATPase TauE PF01925.19 PIK39093.1 - 0.82 9.3 11.7 1.8 8.2 0.2 2.4 2 1 1 3 3 3 0 Sulfite exporter TauE/SafE DUF2516 PF10724.9 PIK39093.1 - 6.1 7.2 7.5 0.37 11.1 0.6 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) Nucleos_tra2_C PF07662.13 PIK39094.1 - 3.3e-78 262.3 1.6 5.5e-78 261.6 1.6 1.3 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus SPX PF03105.19 PIK39094.1 - 0.00014 21.9 9.9 0.00017 21.6 9.9 1.2 1 0 0 1 1 1 1 SPX domain MID_MedPIWI PF18296.1 PIK39094.1 - 0.074 12.8 11.6 0.11 12.3 11.6 1.2 1 0 0 1 1 1 0 MID domain of medPIWI SelP_N PF04592.14 PIK39094.1 - 0.38 10.1 14.7 0.56 9.6 14.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 PIK39094.1 - 1.2 7.8 6.3 1.8 7.2 6.3 1.2 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 PIK39094.1 - 1.9 7.3 22.0 3 6.6 22.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOBP PF15279.6 PIK39094.1 - 2.1 8.9 14.2 2.9 8.4 14.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PPP4R2 PF09184.11 PIK39094.1 - 2.9 7.4 8.1 4 7.0 8.1 1.1 1 0 0 1 1 1 0 PPP4R2 Nucleos_tra2_C PF07662.13 PIK39095.1 - 6.1e-45 153.6 3.9 2.8e-35 122.1 0.1 2.5 2 1 1 3 3 3 2 Na+ dependent nucleoside transporter C-terminus Gate PF07670.14 PIK39095.1 - 0.00058 20.1 1.3 0.00058 20.1 1.3 1.8 2 0 0 2 2 2 1 Nucleoside recognition Ammonium_transp PF00909.21 PIK39096.1 - 4.8e-104 348.2 22.9 6.1e-104 347.9 22.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Ammonium_transp PF00909.21 PIK39097.1 - 1.4e-07 30.6 0.0 1.8e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Ammonium_transp PF00909.21 PIK39098.1 - 3.1e-50 171.0 8.5 3.4e-50 170.9 8.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family RINGv PF12906.7 PIK39099.1 - 5.7e-13 48.8 12.2 1.6e-12 47.3 12.2 1.9 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 PIK39099.1 - 0.017 15.4 11.6 0.08 13.3 10.0 2.8 2 0 0 2 2 2 0 Ring finger domain DUF2142 PF09913.9 PIK39099.1 - 0.045 12.6 0.1 0.067 12.0 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) SET PF00856.28 PIK39100.1 - 3.5e-21 76.3 2.1 7.1e-21 75.3 0.3 2.5 2 0 0 2 2 2 1 SET domain AWS PF17907.1 PIK39100.1 - 1e-16 60.6 9.2 2.7e-16 59.3 9.2 1.8 1 0 0 1 1 1 1 AWS domain Bromodomain PF00439.25 PIK39100.1 - 1.3e-16 60.4 0.5 1.3e-16 60.4 0.5 2.1 2 0 0 2 2 2 1 Bromodomain BAH PF01426.18 PIK39100.1 - 5.5e-12 45.6 0.0 1.3e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 PIK39100.1 - 8.1e-06 25.6 10.3 1.9e-05 24.5 10.3 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK39100.1 - 0.03 13.9 5.5 0.058 13.0 5.5 1.5 1 0 0 1 1 1 0 PHD-finger OHCU_decarbox PF09349.10 PIK39100.1 - 0.071 13.6 0.8 0.16 12.4 0.8 1.5 1 0 0 1 1 1 0 OHCU decarboxylase BTB_2 PF02214.22 PIK39102.1 - 3e-18 66.0 0.0 4.8e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 PIK39102.1 - 0.00023 21.2 0.0 0.00092 19.3 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Adeno_E1B_19K PF01691.16 PIK39102.1 - 0.06 12.9 0.0 0.59 9.7 0.0 2.0 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen Mito_carr PF00153.27 PIK39103.1 - 4.6e-17 61.7 0.3 6e-10 38.9 0.0 2.5 3 0 0 3 3 3 2 Mitochondrial carrier protein DUF1296 PF06972.11 PIK39104.1 - 5.6e-08 32.8 2.0 1.2e-07 31.7 2.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) HBS1_N PF08938.10 PIK39104.1 - 0.0067 16.7 1.3 0.0067 16.7 1.3 1.8 2 0 0 2 2 2 1 HBS1 N-terminus Rv2175c_C PF18367.1 PIK39104.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Rv2175c C-terminal domain of unknown function UBA_4 PF14555.6 PIK39104.1 - 0.03 14.2 0.1 0.042 13.7 0.1 1.2 1 0 0 1 1 1 0 UBA-like domain CUE PF02845.16 PIK39104.1 - 0.038 13.7 0.4 0.038 13.7 0.4 2.0 2 0 0 2 2 2 0 CUE domain DUF4347 PF14252.6 PIK39104.1 - 0.071 12.9 0.2 0.1 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) DUF3697 PF12478.8 PIK39105.1 - 1.8e-08 34.3 0.3 6e-08 32.7 0.3 2.0 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 MFS_1 PF07690.16 PIK39106.1 - 4e-26 91.8 8.3 8.3e-25 87.4 10.5 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39106.1 - 2e-23 83.0 11.7 8.5e-20 71.0 2.4 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter AAA_6 PF12774.7 PIK39106.1 - 0.021 13.8 0.1 0.042 12.8 0.1 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Sugar_tr PF00083.24 PIK39107.1 - 1.1e-18 67.4 14.4 5.7e-14 51.8 7.9 3.4 3 1 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK39107.1 - 2.4e-17 62.9 15.5 3.2e-10 39.5 1.2 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 PIK39107.1 - 0.0084 14.6 2.2 0.0094 14.4 0.4 1.8 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 PIK39108.1 - 9.3e-15 54.4 3.3 9.8e-15 54.4 3.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK39108.1 - 6.3e-13 48.4 17.5 6.3e-13 48.4 17.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Cry1Ac_D5 PF17997.1 PIK39108.1 - 0.047 13.6 0.0 0.11 12.3 0.0 1.6 1 1 1 2 2 2 0 Insecticidal delta-endotoxin CryIA(c) domain 5 MFS_1 PF07690.16 PIK39109.1 - 4.3e-10 39.1 0.0 2.2e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39110.1 - 6.3e-30 104.4 7.8 2.7e-26 92.4 0.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK39110.1 - 9.5e-25 87.3 18.6 2.6e-24 85.8 18.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 PIK39110.1 - 0.00061 18.3 1.4 0.0012 17.4 1.4 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CLN3 PF02487.17 PIK39110.1 - 0.0059 15.7 8.2 0.13 11.3 1.9 2.6 2 1 0 2 2 2 2 CLN3 protein Sugar_tr PF00083.24 PIK39111.1 - 2e-28 99.5 10.9 1.2e-24 87.0 0.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK39111.1 - 7.7e-25 87.6 9.8 2.7e-24 85.7 9.6 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Ebola_NP PF05505.12 PIK39111.1 - 0.24 9.7 2.5 0.34 9.2 2.5 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein MFS_4 PF06779.14 PIK39111.1 - 1.5 8.1 11.8 0.051 12.9 4.0 2.1 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 PIK39113.1 - 1.5e-23 83.4 14.1 6.4e-20 71.4 1.6 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK39113.1 - 2e-22 79.6 12.5 4e-17 62.2 4.2 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily SRCR PF00530.18 PIK39114.1 - 6.2e-52 174.3 9.0 4.6e-19 68.8 0.2 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK39114.1 - 7.5e-18 64.9 8.3 7.6e-09 36.0 0.3 3.6 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK39114.1 - 8.8e-09 35.9 6.1 0.00034 21.1 0.3 3.7 3 1 0 3 3 3 3 Hepsin, SRCR domain Lectin_C PF00059.21 PIK39115.1 - 6.9e-09 36.4 4.4 0.00059 20.5 3.8 3.2 2 1 0 2 2 2 2 Lectin C-type domain UL45 PF05473.12 PIK39115.1 - 0.0036 17.0 0.1 0.0056 16.3 0.1 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like PG_binding_2 PF08823.11 PIK39115.1 - 0.11 12.8 0.3 0.19 12.1 0.3 1.4 1 0 0 1 1 1 0 Putative peptidoglycan binding domain zf-H2C2_2 PF13465.6 PIK39116.1 - 1.9e-24 84.9 19.0 5.6e-10 39.2 0.7 3.9 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39116.1 - 1.8e-15 56.4 24.3 1.3e-05 25.4 0.8 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK39116.1 - 6.9e-12 45.1 22.4 0.00013 22.5 0.6 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK39116.1 - 3.5e-07 30.1 19.6 0.0013 18.6 0.2 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 PIK39116.1 - 2.4e-05 24.3 8.1 0.0012 18.9 2.5 2.5 2 1 0 2 2 2 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 PIK39116.1 - 3.2e-05 23.6 14.7 0.0078 16.0 0.1 3.6 4 0 0 4 4 3 2 zinc-finger C2H2-type FYVE PF01363.21 PIK39116.1 - 0.00017 21.6 9.3 0.019 15.1 2.2 2.3 1 1 1 2 2 2 2 FYVE zinc finger zf-C2H2_jaz PF12171.8 PIK39116.1 - 0.00025 21.2 12.2 0.024 14.9 0.3 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 PIK39116.1 - 0.0003 21.1 4.5 0.0014 18.9 1.7 2.0 2 0 0 2 2 2 1 zinc-finger-containing domain C1_4 PF07975.12 PIK39116.1 - 0.002 18.3 11.9 0.0051 17.0 0.3 3.0 1 1 1 2 2 2 1 TFIIH C1-like domain C1_1 PF00130.22 PIK39116.1 - 0.0021 17.9 13.0 0.16 11.9 1.4 3.0 2 1 1 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_8 PF15909.5 PIK39116.1 - 0.0022 18.3 8.0 0.003 17.8 3.0 2.1 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf_UBZ PF18439.1 PIK39116.1 - 0.0031 17.1 8.1 0.82 9.3 0.2 3.3 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 PIK39116.1 - 0.0076 16.4 12.8 3.4 7.9 1.5 3.3 2 1 1 3 3 3 1 AN1-like Zinc finger zf-C2HC_2 PF13913.6 PIK39116.1 - 0.009 15.9 9.4 1.8 8.5 0.1 3.6 3 0 0 3 3 3 1 zinc-finger of a C2HC-type Elf1 PF05129.13 PIK39116.1 - 0.012 15.6 3.0 0.012 15.6 3.0 2.2 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DUF2321 PF10083.9 PIK39116.1 - 0.044 13.4 5.5 0.056 13.1 0.5 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-CHCC PF10276.9 PIK39116.1 - 0.046 13.8 9.3 0.19 11.8 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger domain zinc-ribbons_6 PF07191.12 PIK39116.1 - 0.068 13.2 9.9 9.7 6.3 9.9 2.9 1 1 0 1 1 1 0 zinc-ribbons FYDLN_acid PF09538.10 PIK39116.1 - 0.088 13.5 4.2 6.8 7.4 0.7 2.8 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-LYAR PF08790.11 PIK39116.1 - 0.092 12.7 9.6 2 8.4 0.2 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger HypA PF01155.19 PIK39116.1 - 0.1 12.6 6.5 0.3 11.1 2.8 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 PIK39116.1 - 0.1 12.5 12.3 0.97 9.4 0.3 2.7 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zf-HYPF PF07503.12 PIK39116.1 - 0.11 12.3 4.9 28 4.6 0.1 3.2 3 0 0 3 3 3 0 HypF finger CpXC PF14353.6 PIK39116.1 - 0.11 12.6 9.2 5.5 7.1 0.5 3.0 1 1 2 3 3 3 0 CpXC protein PyrI_C PF02748.15 PIK39116.1 - 0.15 12.0 8.7 0.19 11.6 0.5 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_9 PF14369.6 PIK39116.1 - 0.15 12.3 2.4 19 5.7 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon zf-trcl PF13451.6 PIK39116.1 - 0.19 11.7 9.9 9 6.3 0.2 3.2 3 0 0 3 3 3 0 Probable zinc-ribbon domain PHD PF00628.29 PIK39116.1 - 0.3 11.0 8.2 0.17 11.8 4.2 2.1 2 0 0 2 2 2 0 PHD-finger XPA_N PF01286.18 PIK39116.1 - 0.3 11.2 8.1 10 6.3 0.2 3.2 3 0 0 3 3 3 0 XPA protein N-terminal zf-HIT PF04438.16 PIK39116.1 - 0.38 10.7 13.9 1.3 9.0 1.7 3.1 3 0 0 3 3 3 0 HIT zinc finger zf-C2HE PF16278.5 PIK39116.1 - 0.38 11.2 15.8 0.49 10.9 0.8 3.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Zf_RING PF16744.5 PIK39116.1 - 0.54 10.4 9.0 1.2 9.3 0.4 2.8 1 1 2 3 3 3 0 KIAA1045 RING finger zinc_ribbon_4 PF13717.6 PIK39116.1 - 0.64 10.0 10.1 4.4 7.3 0.2 3.3 3 0 0 3 3 3 0 zinc-ribbon domain TFIIS_C PF01096.18 PIK39116.1 - 0.7 9.8 11.5 4 7.4 0.6 3.4 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zinc_ribbon_5 PF13719.6 PIK39116.1 - 0.89 9.4 12.2 21 5.0 6.3 3.4 2 1 1 3 3 3 0 zinc-ribbon domain zf-C2H2_2 PF12756.7 PIK39116.1 - 1.4 9.3 13.4 4.9 7.6 1.1 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) HalOD2 PF18547.1 PIK39116.1 - 1.8 8.5 5.5 13 5.8 0.1 3.0 3 0 0 3 3 3 0 Halobacterial output domain 2 zf-UBR PF02207.20 PIK39116.1 - 2 8.7 13.5 27 5.0 13.4 2.6 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF983 PF06170.12 PIK39116.1 - 3.1 8.3 8.1 12 6.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF983) IBR PF01485.21 PIK39116.1 - 3.2 8.1 13.7 0.36 11.1 1.0 3.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Rep_fac-A_C PF08646.10 PIK39116.1 - 3.3 7.4 8.7 0.47 10.2 2.9 2.1 1 1 1 2 2 2 0 Replication factor-A C terminal domain DNA_RNApol_7kD PF03604.13 PIK39116.1 - 3.7 7.3 12.0 9.3 6.0 0.6 3.3 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Rubredoxin_2 PF18073.1 PIK39116.1 - 3.9 7.3 13.4 5.1 6.9 0.4 3.2 3 0 0 3 3 3 0 Rubredoxin metal binding domain HNH PF01844.23 PIK39116.1 - 4.2 7.6 12.1 18 5.6 0.4 3.3 3 0 0 3 3 3 0 HNH endonuclease UPF0004 PF00919.20 PIK39117.1 - 2.7e-20 72.2 0.0 8.7e-20 70.6 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 PIK39117.1 - 3.9e-16 59.9 0.3 1.7e-15 57.8 0.4 1.9 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.20 PIK39117.1 - 7.3e-05 22.7 0.1 0.00013 21.9 0.1 1.5 1 0 0 1 1 1 1 TRAM domain TraT PF05818.12 PIK39117.1 - 0.032 13.9 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein HMG_box PF00505.19 PIK39118.1 - 2.2e-07 31.2 0.0 4.9e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK39118.1 - 1.4e-05 25.6 0.0 3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain Galactosyl_T PF01762.21 PIK39119.1 - 6.1e-22 78.4 0.1 5.3e-20 72.1 0.0 2.2 2 0 0 2 2 2 2 Galactosyltransferase Fringe PF02434.16 PIK39119.1 - 0.042 13.3 0.8 0.086 12.3 0.8 1.4 1 0 0 1 1 1 0 Fringe-like Steroid_dh PF02544.16 PIK39120.1 - 3.3e-33 114.8 1.0 6.6e-33 113.8 1.0 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 PIK39120.1 - 1.8e-05 24.4 0.3 4.1e-05 23.2 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Rdx PF10262.9 PIK39121.1 - 1.3e-06 28.5 0.0 1.5e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Rdx family Polysacc_lyase PF14099.6 PIK39121.1 - 0.033 14.0 0.0 0.036 13.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide lyase CtsR PF05848.11 PIK39121.1 - 0.067 13.1 0.2 0.25 11.3 0.2 2.0 1 1 0 1 1 1 0 CtsR N-terminal HTH domain MltA PF03562.17 PIK39121.1 - 0.09 12.5 0.0 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 MltA specific insert domain Secretogranin_V PF05281.11 PIK39122.1 - 7.7e-05 22.4 4.8 0.0005 19.8 4.8 2.6 1 1 0 1 1 1 1 Neuroendocrine protein 7B2 precursor (Secretogranin V) VitD-bind_III PF09164.10 PIK39122.1 - 0.031 14.3 0.6 0.17 11.9 0.5 2.2 2 0 0 2 2 2 0 Vitamin D binding protein, domain III LTD PF00932.19 PIK39123.1 - 4.1e-08 33.5 2.9 0.0089 16.4 0.1 4.0 4 0 0 4 4 4 3 Lamin Tail Domain Arf PF00025.21 PIK39125.1 - 1.4e-51 174.4 0.0 1.6e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 PIK39125.1 - 1.5e-11 44.2 0.0 1.8e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK39125.1 - 1e-10 41.8 0.0 1.7e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 PIK39125.1 - 1.8e-08 34.1 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 PIK39125.1 - 3e-07 29.9 0.0 4.6e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 PIK39125.1 - 7.3e-06 25.5 0.0 1.1e-05 25.0 0.0 1.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MeaB PF03308.16 PIK39125.1 - 0.058 12.4 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Kelch_3 PF13415.6 PIK39126.1 - 6.2e-28 96.5 7.3 5.9e-06 26.4 0.1 7.9 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK39126.1 - 8.2e-19 67.4 14.0 0.00012 22.0 0.2 7.7 7 1 1 8 8 8 7 Galactose oxidase, central domain Kelch_1 PF01344.25 PIK39126.1 - 9.7e-15 53.9 11.7 0.063 12.9 0.0 7.5 7 1 0 7 7 7 5 Kelch motif Kelch_5 PF13854.6 PIK39126.1 - 7.2e-12 45.0 11.2 0.049 13.6 0.0 6.2 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 PIK39126.1 - 1e-10 41.5 18.8 0.01 16.1 0.2 7.2 5 2 2 7 7 7 4 Kelch motif Kelch_2 PF07646.15 PIK39126.1 - 2.7e-07 30.3 17.9 0.17 11.9 0.2 7.7 7 1 0 7 7 7 3 Kelch motif HLH PF00010.26 PIK39127.1 - 2.4e-08 33.8 0.0 4.2e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Baculo_PEP_C PF04513.12 PIK39127.1 - 0.029 14.4 1.3 0.04 14.0 1.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MRFAP1 PF15155.6 PIK39127.1 - 0.092 13.3 0.1 0.32 11.5 0.1 1.7 2 0 0 2 2 2 0 MORF4 family-associated protein1 Homeodomain PF00046.29 PIK39128.1 - 1.8e-22 78.9 4.6 1.8e-22 78.9 4.6 1.6 2 0 0 2 2 2 1 Homeodomain DUF4230 PF14014.6 PIK39128.1 - 0.26 11.5 4.6 0.29 11.4 4.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4230) DUF3437 PF11919.8 PIK39128.1 - 0.35 10.8 3.0 2 8.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) EF-hand_7 PF13499.6 PIK39129.1 - 2e-17 63.4 14.2 2.6e-09 37.4 4.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK39129.1 - 2.3e-15 55.1 8.8 0.0013 18.5 0.1 5.0 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 PIK39129.1 - 3.7e-11 41.7 4.7 0.061 12.9 0.0 5.3 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 PIK39129.1 - 0.00022 20.6 7.3 0.21 11.1 0.0 3.9 4 0 0 4 4 4 2 EF hand TFIIA PF03153.13 PIK39129.1 - 0.0012 19.0 14.8 0.0017 18.5 14.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EF-hand_8 PF13833.6 PIK39129.1 - 0.0022 17.8 4.0 0.54 10.2 0.1 3.9 3 0 0 3 3 3 1 EF-hand domain pair ExbD PF02472.16 PIK39129.1 - 0.18 12.0 5.9 0.35 11.0 5.9 1.4 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF1040 PF06288.13 PIK39129.1 - 0.94 9.9 5.8 1.9 8.9 0.1 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1040) TAF1_subA PF14929.6 PIK39130.1 - 1e-33 117.3 2.7 1.5e-33 116.8 2.7 1.2 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A TPR_14 PF13428.6 PIK39130.1 - 0.0015 19.2 0.0 0.19 12.7 0.1 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39130.1 - 0.013 15.7 0.1 0.036 14.3 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39130.1 - 0.068 13.0 0.4 0.14 12.0 0.4 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK39130.1 - 0.13 13.0 0.6 0.67 10.7 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39130.1 - 0.16 12.2 0.4 0.38 11.0 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SMC_N PF02463.19 PIK39131.1 - 2e-24 86.3 17.5 5.6e-24 84.8 17.3 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK39131.1 - 9.1e-18 64.7 0.7 2.6e-17 63.2 0.7 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain Ras PF00071.22 PIK39132.1 - 2.1e-62 209.5 1.8 2.6e-62 209.2 1.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK39132.1 - 1.1e-33 115.9 0.9 2.1e-33 115.1 0.9 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK39132.1 - 6.4e-15 55.0 0.3 8.6e-15 54.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK39132.1 - 3.9e-05 23.2 0.2 0.00031 20.2 0.0 1.9 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK39132.1 - 0.00013 22.1 0.1 0.00078 19.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK39132.1 - 0.00053 19.6 0.1 0.0016 18.0 0.1 1.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK39132.1 - 0.00067 19.1 0.3 0.00099 18.5 0.3 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 PIK39132.1 - 0.0011 18.5 0.0 0.89 9.1 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK39132.1 - 0.0026 17.7 0.1 0.67 9.8 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 PIK39132.1 - 0.0031 16.7 1.3 1.1 8.3 0.0 3.0 1 1 1 2 2 2 1 G-protein alpha subunit DUF3873 PF12989.7 PIK39132.1 - 0.025 14.9 0.1 0.05 14.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Septin PF00735.18 PIK39132.1 - 0.067 12.4 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Septin DUF2757 PF10955.8 PIK39132.1 - 0.11 12.7 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) CTP_transf_3 PF02348.19 PIK39133.1 - 3.4e-39 135.1 0.0 4.2e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 PIK39133.1 - 1.3e-06 28.9 0.0 2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Ank_2 PF12796.7 PIK39135.1 - 9.4e-09 35.7 0.2 2.5e-08 34.4 0.2 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK39135.1 - 4.4e-07 30.1 0.1 1.2e-06 28.7 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK39135.1 - 5.1e-06 26.9 0.0 1.2e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK39135.1 - 0.0003 21.0 0.2 0.011 16.2 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 PIK39135.1 - 0.00053 20.3 0.4 0.0016 18.8 0.4 1.9 1 0 0 1 1 1 1 Ankyrin repeat ubiquitin PF00240.23 PIK39135.1 - 0.00084 19.1 0.1 0.0021 17.8 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family DUF3369 PF11849.8 PIK39135.1 - 0.0032 17.7 0.2 0.0047 17.2 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3369) DUF3939 PF13075.6 PIK39135.1 - 0.097 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) UN_NPL4 PF11543.8 PIK39135.1 - 0.14 12.6 0.8 0.55 10.7 0.2 2.1 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 SYS1 PF09801.9 PIK39136.1 - 1.4e-49 167.9 6.1 1.6e-49 167.8 6.1 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Aminotran_5 PF00266.19 PIK39137.1 - 4.5e-77 259.5 0.0 5.3e-77 259.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 PIK39137.1 - 1.7e-08 34.1 0.0 2.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 PIK39137.1 - 9e-06 25.2 0.1 1.2e-05 24.8 0.1 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 PIK39137.1 - 0.0006 18.6 0.0 0.00087 18.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF5114 PF17141.4 PIK39137.1 - 0.13 12.9 0.0 0.46 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5114) DUF724 PF05266.14 PIK39137.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DAO PF01266.24 PIK39139.1 - 1.4e-29 103.8 0.0 1.9e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK39139.1 - 0.041 13.1 0.1 0.067 12.4 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 PIK39139.1 - 0.077 12.3 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Meiosis_expr PF15163.6 PIK39140.1 - 0.032 14.9 0.3 0.053 14.2 0.3 1.3 1 0 0 1 1 1 0 Meiosis-expressed UL45 PF05473.12 PIK39140.1 - 0.038 13.6 0.7 0.044 13.4 0.7 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like zf-CCHC PF00098.23 PIK39142.1 - 1.9e-05 24.5 1.4 2.9e-05 23.9 0.6 1.7 2 0 0 2 2 2 1 Zinc knuckle Retrotran_gag_2 PF14223.6 PIK39142.1 - 0.0004 20.0 0.0 0.0008 19.1 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type TerY_C PF15616.6 PIK39142.1 - 0.0046 17.1 0.3 0.015 15.4 0.1 1.8 2 0 0 2 2 2 1 TerY-C metal binding domain Glyoxalase_2 PF12681.7 PIK39142.1 - 0.0095 15.9 0.3 1.2 9.1 0.0 2.9 1 1 2 3 3 3 1 Glyoxalase-like domain DIX PF00778.17 PIK39142.1 - 0.056 13.3 1.0 0.33 10.8 0.2 2.2 2 0 0 2 2 2 0 DIX domain zf-CCHC_6 PF15288.6 PIK39142.1 - 0.1 12.4 0.4 0.36 10.7 0.1 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK39142.1 - 2 8.2 6.4 11 5.8 0.6 3.3 3 0 0 3 3 3 0 Zinc knuckle RVT_2 PF07727.14 PIK39143.1 - 2.2e-37 129.0 0.1 2.5e-37 128.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK39144.1 - 9.2e-24 84.4 0.1 1.3e-23 83.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Fib_alpha PF08702.10 PIK39145.1 - 0.087 13.0 0.2 0.11 12.7 0.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family SH3_9 PF14604.6 PIK39146.1 - 1.5e-05 24.8 0.1 4.5e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain O-FucT PF10250.9 PIK39146.1 - 0.00037 20.3 0.1 0.004 16.9 0.1 2.1 1 1 0 2 2 2 1 GDP-fucose protein O-fucosyltransferase ERM PF00769.19 PIK39147.1 - 0.02 14.7 46.4 0.011 15.6 25.0 2.4 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DUF2095 PF09868.9 PIK39147.1 - 2.2 8.3 12.6 2.3 8.2 2.2 2.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) BORCS7 PF16088.5 PIK39147.1 - 2.4 8.5 15.4 0.58 10.4 2.7 3.9 3 1 2 5 5 5 0 BLOC-1-related complex sub-unit 7 MIT_C PF16565.5 PIK39147.1 - 7.5 6.5 10.8 0.39 10.7 2.4 2.8 1 1 2 3 3 3 0 Phospholipase D-like domain at C-terminus of MIT BLOC1_2 PF10046.9 PIK39147.1 - 7.7 6.9 33.6 0.19 12.1 2.0 4.5 3 1 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mito_carr PF00153.27 PIK39148.1 - 7.7e-24 83.5 2.2 4.4e-21 74.6 0.1 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein Methyltransf_3 PF01596.17 PIK39149.1 - 1.3e-30 106.2 0.0 1.9e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 PIK39149.1 - 8.1e-08 33.2 0.0 1.5e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39149.1 - 1.3e-07 32.2 0.0 2.9e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK39149.1 - 1.2e-06 28.5 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39149.1 - 0.00082 20.1 0.0 0.0016 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39149.1 - 0.00083 20.0 0.0 0.0019 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK39149.1 - 0.0059 16.4 0.0 0.0075 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 PIK39149.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 PIK39149.1 - 0.058 12.3 0.0 0.082 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Cons_hypoth95 PF03602.15 PIK39149.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Ig_3 PF13927.6 PIK39150.1 - 3.5e-11 43.5 0.6 3.5e-05 24.3 0.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK39150.1 - 1.7e-10 40.9 0.4 5.7e-05 23.2 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK39150.1 - 4e-09 36.4 1.0 0.0034 17.4 0.2 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK39150.1 - 9.4e-07 29.1 4.6 0.002 18.4 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 PIK39150.1 - 0.00047 20.5 0.6 0.044 14.2 0.1 3.2 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK39150.1 - 0.00074 19.5 0.0 0.027 14.5 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain V-set PF07686.17 PIK39150.1 - 0.019 15.1 1.4 0.84 9.8 0.1 2.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK39151.1 - 1.7e-19 70.1 0.0 2.6e-18 66.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39151.1 - 4.5e-11 42.6 0.0 9e-11 41.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK39152.1 - 2.1e-05 24.6 0.4 0.02 15.1 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK39152.1 - 6.7e-05 23.4 1.1 3.1 8.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 PIK39152.1 - 0.034 13.7 0.0 0.082 12.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain RT_RNaseH_2 PF17919.1 PIK39153.1 - 5.2e-30 103.4 0.0 9.5e-30 102.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK39153.1 - 2.3e-26 92.1 0.0 3.9e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39153.1 - 2.6e-18 66.4 0.2 6.3e-18 65.1 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK39153.1 - 2.4e-13 50.0 0.0 6.5e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DTHCT PF08070.11 PIK39154.1 - 0.024 15.4 1.4 0.024 15.4 1.4 1.6 2 0 0 2 2 2 0 DTHCT (NUC029) region IgGFc_binding PF17517.2 PIK39155.1 - 4.1e-31 108.4 3.1 5e-31 108.1 3.1 1.0 1 0 0 1 1 1 1 IgGFc binding protein BetaGal_dom3 PF13363.6 PIK39155.1 - 0.016 14.7 1.3 6.4 6.4 0.0 3.4 2 1 1 3 3 3 0 Beta-galactosidase, domain 3 Fz PF01392.22 PIK39156.1 - 3e-95 314.4 57.7 1.9e-25 89.6 4.0 6.5 6 0 0 6 6 6 6 Fz domain Fz PF01392.22 PIK39157.1 - 2.3e-45 153.8 24.7 4.6e-20 72.3 4.2 3.1 3 0 0 3 3 3 3 Fz domain Fz PF01392.22 PIK39158.1 - 4.9e-21 75.4 7.1 7.1e-21 74.9 7.1 1.2 1 0 0 1 1 1 1 Fz domain Trypan_PARP PF05887.11 PIK39158.1 - 0.017 15.1 12.1 0.028 14.4 12.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 PIK39158.1 - 0.32 11.5 8.6 0.5 10.9 8.6 1.3 1 0 0 1 1 1 0 TonB polyproline region adh_short PF00106.25 PIK39159.1 - 5e-29 101.2 0.0 6.9e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39159.1 - 3.2e-14 53.1 0.0 4e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39159.1 - 1.6e-08 34.7 0.2 3.1e-08 33.7 0.2 1.4 1 0 0 1 1 1 1 KR domain DDR_swiveling PF18427.1 PIK39159.1 - 0.042 13.9 0.1 0.085 12.9 0.1 1.4 1 0 0 1 1 1 0 DD-reactivating factor swiveling domain adh_short PF00106.25 PIK39160.1 - 2.4e-21 76.1 0.0 3.9e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39160.1 - 5.4e-14 52.3 0.0 7e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39160.1 - 8.7e-06 25.8 0.0 2e-05 24.6 0.0 1.5 2 0 0 2 2 2 1 KR domain adh_short PF00106.25 PIK39161.1 - 2.5e-26 92.4 0.0 2.9e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39161.1 - 2.4e-12 46.9 0.0 3e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39161.1 - 6e-05 23.0 0.1 8.9e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 KR domain TM231 PF10149.9 PIK39163.1 - 3e-58 197.6 0.1 3.4e-58 197.4 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 231 Presenilin PF01080.17 PIK39164.1 - 2.4 6.8 13.2 2.7 6.7 13.2 1.1 1 0 0 1 1 1 0 Presenilin adh_short PF00106.25 PIK39165.1 - 1.1e-53 181.7 0.0 1.4e-53 181.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39165.1 - 9.9e-30 103.8 0.0 1.4e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39165.1 - 1.8e-12 47.5 0.0 2.5e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK39165.1 - 0.0011 18.1 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 PIK39165.1 - 0.0017 18.6 0.1 0.0028 17.9 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 PIK39165.1 - 0.0061 16.1 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ApbA PF02558.16 PIK39165.1 - 0.029 14.0 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3Beta_HSD PF01073.19 PIK39165.1 - 0.12 11.4 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ras PF00071.22 PIK39166.1 - 6.2e-29 100.7 0.0 8.1e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK39166.1 - 2.6e-21 76.1 0.0 7.1e-21 74.7 0.0 1.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK39166.1 - 2.3e-09 36.9 0.0 3.4e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 PIK39166.1 - 1.6e-05 25.2 0.1 0.00025 21.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 PIK39166.1 - 0.00013 22.1 0.0 0.00024 21.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK39166.1 - 0.00015 21.7 0.0 0.0039 17.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 PIK39166.1 - 0.0026 17.5 0.0 0.043 13.6 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 PIK39166.1 - 0.0059 16.0 0.0 0.013 14.9 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 PIK39166.1 - 0.0091 16.4 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 PIK39166.1 - 0.014 15.4 0.0 0.034 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 PIK39166.1 - 0.017 14.6 0.1 0.091 12.2 0.0 2.1 2 1 1 3 3 3 0 Bacterial TniB protein Septin PF00735.18 PIK39166.1 - 0.029 13.7 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Septin G-alpha PF00503.20 PIK39166.1 - 0.031 13.4 0.1 0.096 11.8 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 PIK39166.1 - 0.067 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK39166.1 - 0.089 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DLIC PF05783.11 PIK39166.1 - 0.096 11.5 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 PIK39166.1 - 0.11 13.1 0.7 0.21 12.1 0.7 1.9 1 1 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 PIK39166.1 - 0.18 11.5 0.0 0.36 10.5 0.0 1.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Complex1_30kDa PF00329.19 PIK39167.1 - 5.7e-43 146.4 0.0 8e-43 146.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF4765 PF15962.5 PIK39167.1 - 0.07 11.1 0.1 0.084 10.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4765) DEP PF00610.21 PIK39168.1 - 2.3e-14 53.2 0.3 1.2e-13 50.9 0.1 2.3 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ECH_1 PF00378.20 PIK39169.1 - 7.6e-35 120.4 0.0 8.3e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK39169.1 - 1e-09 38.4 0.0 1.8e-09 37.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.19 PIK39170.1 - 1.1e-27 96.1 0.0 2.4e-27 94.9 0.0 1.6 2 0 0 2 2 2 1 Acyl CoA binding protein EGF PF00008.27 PIK39171.1 - 5.7e-33 112.9 85.2 8.2e-08 32.4 11.9 7.0 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK39171.1 - 4.3e-17 62.0 67.6 0.00018 22.0 6.5 7.8 6 0 0 6 6 6 5 Human growth factor-like EGF DUF1759 PF03564.15 PIK39171.1 - 4.8e-09 36.3 0.0 9.4e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) EGF_2 PF07974.13 PIK39171.1 - 2.2e-07 31.1 101.5 0.013 15.9 14.2 7.4 7 0 0 7 7 7 5 EGF-like domain Asp_protease_2 PF13650.6 PIK39171.1 - 0.1 13.2 0.1 0.24 12.1 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Peptidase_A17 PF05380.13 PIK39172.1 - 3.6e-58 196.1 0.0 1.5e-57 194.1 0.0 1.9 2 0 0 2 2 2 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK39172.1 - 6.8e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK39172.1 - 9.6e-05 22.4 0.0 0.00042 20.3 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK39172.1 - 0.00028 21.1 0.0 0.00072 19.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase EGF PF00008.27 PIK39173.1 - 1.3e-18 66.9 29.8 6.8e-08 32.7 8.7 3.9 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK39173.1 - 4.6e-05 23.9 8.0 4.6e-05 23.9 8.0 5.0 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK39173.1 - 5.5e-05 23.4 38.2 0.0015 18.9 10.6 4.0 4 0 0 4 4 4 3 EGF-like domain cEGF PF12662.7 PIK39173.1 - 1.6 8.7 10.1 0.29 11.1 4.5 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF PF00008.27 PIK39174.1 - 2.8e-19 69.1 42.0 2.2e-07 31.0 11.3 3.9 3 0 0 3 3 3 3 EGF-like domain Ig_3 PF13927.6 PIK39174.1 - 4.4e-07 30.4 3.2 5.8e-06 26.8 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK39174.1 - 7.8e-07 29.1 0.0 2.4e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain hEGF PF12661.7 PIK39174.1 - 3.5e-05 24.2 20.8 0.0012 19.4 7.3 5.2 6 0 0 6 6 6 2 Human growth factor-like EGF ig PF00047.25 PIK39174.1 - 6.5e-05 23.0 0.0 0.00043 20.4 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain EGF_2 PF07974.13 PIK39174.1 - 8.9e-05 22.8 46.4 0.026 14.9 14.9 3.7 3 0 0 3 3 3 3 EGF-like domain HYR PF02494.16 PIK39174.1 - 0.0026 18.0 0.0 0.0075 16.6 0.0 1.8 1 0 0 1 1 1 1 HYR domain VWC PF00093.18 PIK39175.1 - 1.6e-13 50.7 40.7 6.2e-08 32.8 16.8 2.4 2 0 0 2 2 2 2 von Willebrand factor type C domain CFC PF09443.10 PIK39175.1 - 6.7 6.6 19.3 0.92 9.4 2.0 3.0 2 1 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) PNMA PF14893.6 PIK39176.1 - 1.3e-05 24.8 0.0 2.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 PNMA DUF3552 PF12072.8 PIK39176.1 - 0.056 12.9 2.4 0.088 12.2 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) RVT_1 PF00078.27 PIK39177.1 - 3.5e-33 115.0 0.1 9.3e-33 113.6 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK39177.1 - 1.5e-23 83.0 0.2 6.5e-23 81.0 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK39177.1 - 3.2e-15 56.0 0.0 8.3e-15 54.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Staphostatin_B PF09023.10 PIK39178.1 - 0.068 13.2 0.6 0.13 12.3 0.6 1.4 1 0 0 1 1 1 0 Staphostatin B Kelch_4 PF13418.6 PIK39178.1 - 0.17 11.9 0.0 85 3.3 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain MINDY_DUB PF04424.13 PIK39179.1 - 1.7e-35 121.6 0.1 3e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase Phage_ABA_S PF18066.1 PIK39179.1 - 0.0097 16.6 0.0 0.027 15.2 0.0 1.7 1 0 0 1 1 1 1 Phage ABA sandwich domain Toxin_8 PF07365.12 PIK39179.1 - 0.16 12.2 0.3 0.44 10.8 0.3 1.8 1 0 0 1 1 1 0 Alpha conotoxin precursor PHD PF00628.29 PIK39180.1 - 1.5e-08 34.4 6.7 2.8e-08 33.5 6.7 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK39180.1 - 2.9e-07 29.9 3.9 2.9e-07 29.9 3.9 1.8 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 PIK39180.1 - 0.0052 16.6 0.9 0.0052 16.6 0.9 1.8 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF5569 PF17729.1 PIK39180.1 - 0.15 11.9 0.3 0.87 9.4 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5569) NACHT PF05729.12 PIK39181.1 - 2.2e-14 53.7 0.0 4.6e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK39181.1 - 7.6e-09 36.2 0.3 2.1e-07 31.5 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain DUF4062 PF13271.6 PIK39181.1 - 8e-08 32.6 0.0 2.2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) AAA_22 PF13401.6 PIK39181.1 - 1.8e-05 25.1 0.0 7.7e-05 23.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 PIK39181.1 - 0.00038 20.4 0.0 0.00091 19.2 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF2408 PF10303.9 PIK39181.1 - 0.08 13.5 0.6 0.32 11.5 0.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) APAF1_C PF17908.1 PIK39181.1 - 0.084 12.9 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 APAF-1 helical domain RsgA_GTPase PF03193.16 PIK39181.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase 7tm_1 PF00001.21 PIK39182.1 - 1e-34 120.1 17.2 1.8e-34 119.3 17.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK39182.1 - 1.3e-08 34.5 15.3 2.2e-08 33.8 15.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK39182.1 - 1.7e-05 24.6 23.9 2.8e-05 23.9 23.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4407 PF14362.6 PIK39182.1 - 1.4 8.2 3.0 2.8 7.2 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MFS_1 PF07690.16 PIK39183.1 - 1.1e-07 31.1 0.1 1.4e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK39183.1 - 0.0058 15.2 0.3 0.071 11.7 0.0 2.0 2 0 0 2 2 2 2 MFS/sugar transport protein Pkinase_Tyr PF07714.17 PIK39184.1 - 6.3e-17 61.7 0.0 7.4e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39184.1 - 1.8e-16 60.3 0.0 2.2e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain CD225 PF04505.12 PIK39185.1 - 1.6e-12 47.4 7.0 4.3e-11 42.8 7.0 2.2 1 1 0 1 1 1 1 Interferon-induced transmembrane protein Pro-rich PF15240.6 PIK39185.1 - 3.3 8.0 45.8 4.4 7.5 45.8 1.1 1 0 0 1 1 1 0 Proline-rich CD225 PF04505.12 PIK39186.1 - 6.2e-25 87.1 1.2 9.3e-25 86.6 1.2 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 PIK39186.1 - 0.0052 16.5 7.6 0.017 14.9 6.6 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4190) AA_permease_2 PF13520.6 PIK39187.1 - 2.8e-18 66.0 13.0 3.3e-18 65.7 13.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK39187.1 - 4.2e-07 28.9 10.7 5.6e-07 28.5 10.7 1.0 1 0 0 1 1 1 1 Amino acid permease CTU2 PF10288.9 PIK39188.1 - 7e-19 68.1 4.8 2.5e-18 66.4 4.8 2.0 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 PIK39188.1 - 2.2e-07 30.8 0.0 0.023 14.4 0.0 2.2 2 0 0 2 2 2 2 PP-loop family Glucosamine_iso PF01182.20 PIK39188.1 - 0.072 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 7tm_1 PF00001.21 PIK39189.1 - 1.4e-19 70.4 15.8 4.4e-19 68.8 15.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39189.1 - 1.3e-07 31.5 9.6 1.7e-07 31.2 9.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39189.1 - 0.029 13.8 7.6 0.023 14.1 6.0 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx RB_B PF01857.20 PIK39190.1 - 2.7e-51 173.1 0.0 3.8e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Rb_C PF08934.10 PIK39190.1 - 0.033 14.0 2.1 0.1 12.4 2.1 1.8 1 0 0 1 1 1 0 Rb C-terminal domain KRBA1 PF15287.6 PIK39190.1 - 0.14 11.8 0.1 0.14 11.8 0.1 2.6 3 0 0 3 3 3 0 KRBA1 family repeat Neurensin PF14927.6 PIK39191.1 - 0.022 14.5 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Neurensin DUF563 PF04577.14 PIK39192.1 - 5e-08 33.3 0.0 6.9e-08 32.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF563) cNMP_binding PF00027.29 PIK39194.1 - 9.9e-17 60.8 0.0 2.6e-16 59.5 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 PIK39194.1 - 1.7e-12 47.1 15.0 2.6e-12 46.5 15.0 1.2 1 0 0 1 1 1 1 Ion transport protein CdhD PF03599.16 PIK39194.1 - 0.091 11.5 0.0 0.18 10.5 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF4618 PF15397.6 PIK39195.1 - 3.4e-29 102.1 26.1 4.1e-29 101.8 26.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) GLTP PF08718.11 PIK39195.1 - 0.28 11.5 7.1 3 8.1 0.2 2.4 1 1 0 2 2 2 0 Glycolipid transfer protein (GLTP) DUF4458 PF14660.6 PIK39195.1 - 1.1 9.5 5.9 0.54 10.5 2.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4458) FliJ PF02050.16 PIK39195.1 - 1.2 9.4 26.4 1.4 9.2 5.8 3.3 1 1 1 3 3 3 0 Flagellar FliJ protein DUF4407 PF14362.6 PIK39195.1 - 2.8 7.2 9.3 5 6.4 9.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) NHL PF01436.21 PIK39198.1 - 2.8e-08 33.4 0.4 6.9e-07 29.0 0.0 2.7 2 0 0 2 2 2 1 NHL repeat PQQ_3 PF13570.6 PIK39198.1 - 0.055 14.0 2.7 10 6.8 1.6 3.1 2 1 0 2 2 2 0 PQQ-like domain Epimerase PF01370.21 PIK39200.1 - 1.9e-12 47.1 0.0 1.9e-11 43.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK39200.1 - 7.9e-10 38.2 0.0 4.2e-05 22.7 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK39200.1 - 9.1e-09 35.5 0.0 1.5e-08 34.8 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 PIK39200.1 - 5.4e-06 25.7 0.0 0.0016 17.6 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NmrA PF05368.13 PIK39200.1 - 9.7e-06 25.3 0.0 0.00071 19.2 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 PIK39200.1 - 0.00016 20.9 0.0 0.28 10.3 0.0 2.8 2 1 1 3 3 3 2 Male sterility protein GDP_Man_Dehyd PF16363.5 PIK39200.1 - 0.012 15.0 0.0 0.025 14.0 0.0 1.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DIM1 PF02966.16 PIK39201.1 - 1.6e-65 218.8 0.1 1.8e-65 218.7 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 PIK39201.1 - 2.9e-05 24.0 0.1 3.6e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Imm43 PF15570.6 PIK39202.1 - 0.057 13.4 0.3 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 Immunity protein 43 zf-H2C2_2 PF13465.6 PIK39203.1 - 2.3e-41 138.4 43.2 4.3e-09 36.4 1.4 6.7 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39203.1 - 1.8e-29 100.6 52.2 1.9e-05 24.8 0.4 7.5 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK39203.1 - 2.7e-18 65.1 46.6 0.0038 17.9 0.3 7.5 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39203.1 - 1.1e-10 41.5 15.5 0.2 12.0 0.2 6.6 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK39203.1 - 1.9e-06 28.1 20.3 0.053 13.8 2.8 3.7 1 1 2 3 3 3 3 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 PIK39203.1 - 0.00059 20.0 21.6 0.0077 16.4 0.4 4.9 2 2 3 5 5 5 2 Aberrant zinc-finger zf-TRAF PF02176.18 PIK39203.1 - 0.021 15.5 1.3 0.021 15.5 1.3 3.6 2 1 1 3 3 3 0 TRAF-type zinc finger DeoRC PF00455.22 PIK39203.1 - 0.043 13.7 0.6 2.8 7.9 0.0 3.0 2 1 1 3 3 3 0 DeoR C terminal sensor domain FOXP-CC PF16159.5 PIK39203.1 - 0.049 14.3 13.3 1.2 9.8 0.1 5.2 4 1 1 5 5 5 0 FOXP coiled-coil domain CopK PF11525.8 PIK39203.1 - 0.099 12.3 3.4 8.3 6.1 0.0 3.9 3 1 0 4 4 4 0 Copper resistance protein K zf-C2H2_11 PF16622.5 PIK39203.1 - 0.21 11.4 25.6 4.3 7.2 0.2 5.7 6 0 0 6 6 6 0 zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 PIK39203.1 - 0.6 9.8 11.6 1.6 8.4 0.0 4.4 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain XPA_N PF01286.18 PIK39203.1 - 3.2 7.9 5.9 1.8 8.7 0.1 3.5 5 0 0 5 5 5 0 XPA protein N-terminal Stealth_CR2 PF11380.8 PIK39204.1 - 6.7e-45 151.7 0.2 3.5e-44 149.4 0.0 2.4 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR4 PF17103.5 PIK39204.1 - 8.1e-22 76.9 1.7 1.7e-21 75.9 0.5 2.3 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Notch PF00066.17 PIK39204.1 - 2.7e-14 53.3 35.5 1.6e-08 34.9 13.4 2.6 2 0 0 2 2 2 2 LNR domain Stealth_CR3 PF17102.5 PIK39204.1 - 2.8e-14 52.7 6.8 2.8e-14 52.7 6.8 1.7 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 DMAP_binding PF06464.11 PIK39204.1 - 1.8e-08 35.1 6.9 1.8e-08 35.1 6.9 2.7 3 0 0 3 3 2 1 DMAP1-binding Domain GlcNAc-1_reg PF18440.1 PIK39204.1 - 2.7e-05 24.3 0.1 9e-05 22.6 0.1 2.0 1 0 0 1 1 1 1 Putative GlcNAc-1 phosphotransferase regulatory domain EF-hand_1 PF00036.32 PIK39204.1 - 0.0022 17.4 0.0 0.0092 15.5 0.0 2.1 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 PIK39204.1 - 0.0058 16.1 0.2 0.021 14.3 0.2 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 PIK39204.1 - 0.02 14.7 0.1 0.02 14.7 0.1 2.1 2 0 0 2 2 1 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK39204.1 - 0.028 14.3 0.0 0.1 12.6 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 PIK39204.1 - 0.048 14.1 0.1 0.44 11.0 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair Gemini_AL1_M PF08283.11 PIK39204.1 - 0.1 12.7 1.3 5 7.3 0.0 3.4 3 0 0 3 3 3 0 Geminivirus rep protein central domain GTP_EFTU_D3 PF03143.17 PIK39205.1 - 2.3e-43 147.0 0.2 1.2e-42 144.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 PIK39205.1 - 8e-17 61.4 0.4 1.8e-16 60.3 0.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 PIK39205.1 - 0.012 15.5 1.0 0.022 14.7 0.3 1.8 2 0 0 2 2 2 0 Elongation factor Tu domain 4 GTP_EFTU PF00009.27 PIK39206.1 - 9.7e-41 139.4 0.1 1.1e-40 139.2 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK39206.1 - 1.3e-05 25.3 0.1 0.00054 20.0 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK39206.1 - 0.0099 15.9 0.0 3.9 7.5 0.0 2.1 2 0 0 2 2 2 2 Dynamin family SRPRB PF09439.10 PIK39206.1 - 0.021 14.3 0.1 0.3 10.5 0.0 2.1 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 PIK39206.1 - 0.072 12.4 0.1 2.1 7.6 0.0 2.0 2 0 0 2 2 2 0 AIG1 family G-alpha PF00503.20 PIK39206.1 - 0.099 11.8 0.3 1.1 8.4 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 PIK39206.1 - 0.12 11.9 0.1 1.2 8.6 0.0 2.1 1 1 1 2 2 2 0 Ferrous iron transport protein B Septin PF00735.18 PIK39206.1 - 0.12 11.6 0.1 0.38 10.0 0.1 1.6 1 1 0 1 1 1 0 Septin Pkinase PF00069.25 PIK39207.1 - 1.8e-19 70.1 0.0 2.2e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39207.1 - 1.6e-06 27.6 0.0 2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_1 PF00018.28 PIK39208.1 - 1.8e-13 49.8 0.2 2.5e-13 49.4 0.2 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK39208.1 - 8.5e-11 41.4 0.1 1.3e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK39208.1 - 1.4e-10 40.9 0.2 2e-10 40.4 0.2 1.2 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 PIK39208.1 - 0.039 13.7 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) BAR_3 PF16746.5 PIK39209.1 - 5.2e-17 62.3 6.0 1.2e-16 61.2 6.0 1.6 1 1 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 PIK39209.1 - 4.8e-08 33.1 1.6 2.2e-05 24.5 2.9 3.1 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf PH PF00169.29 PIK39209.1 - 3e-05 24.5 5.0 0.00053 20.5 0.3 3.5 2 2 1 3 3 3 1 PH domain DUF4404 PF14357.6 PIK39209.1 - 0.0043 17.7 0.4 0.069 13.8 0.3 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4404) CCDC74_C PF14917.6 PIK39209.1 - 0.11 13.0 0.4 0.29 11.7 0.4 1.7 1 0 0 1 1 1 0 Coiled coil protein 74, C terminal PH_9 PF15410.6 PIK39209.1 - 0.13 12.7 0.6 1.3 9.4 0.2 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain Dimer_Tnp_hAT PF05699.14 PIK39211.1 - 2.1e-09 37.0 0.3 3.9e-09 36.2 0.3 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region NAD_binding_10 PF13460.6 PIK39212.1 - 1.8e-24 86.6 0.1 2.1e-24 86.4 0.1 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK39212.1 - 4.8e-10 39.4 0.3 5.8e-10 39.1 0.3 1.0 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK39212.1 - 1.9e-06 27.6 0.2 2.6e-06 27.1 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK39212.1 - 0.01 16.1 0.2 0.014 15.7 0.2 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 PIK39212.1 - 0.018 14.1 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DFP PF04127.15 PIK39212.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein OSTMP1 PF09777.9 PIK39213.1 - 6.1e-45 153.4 16.9 7.4e-45 153.2 16.9 1.1 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor DZR PF12773.7 PIK39213.1 - 0.017 15.1 4.7 0.099 12.7 0.3 2.8 2 2 0 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 PIK39213.1 - 1.8 8.4 8.6 0.49 10.2 0.3 3.1 3 0 0 3 3 3 0 zinc-ribbon domain DUF1189 PF06691.11 PIK39213.1 - 3 7.3 7.7 4.7 6.7 7.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1189) zf-RING_5 PF14634.6 PIK39213.1 - 3.7 7.6 10.2 32 4.6 0.3 4.1 3 1 1 4 4 4 0 zinc-RING finger domain NuA4 PF09340.10 PIK39214.1 - 4.8e-25 87.2 1.2 4.8e-25 87.2 1.2 2.3 2 1 0 2 2 2 1 Histone acetyltransferase subunit NuA4 PI3K_1B_p101 PF10486.9 PIK39214.1 - 0.31 8.8 9.1 0.37 8.5 9.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ALMT PF11744.8 PIK39214.1 - 0.59 8.9 4.4 0.72 8.6 4.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LIN37 PF15306.6 PIK39214.1 - 2.6 8.3 10.1 25 5.0 7.3 2.1 1 1 1 2 2 2 0 LIN37 GET2 PF08690.10 PIK39214.1 - 7.4 6.2 11.6 10 5.7 11.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 zf-C4 PF00105.18 PIK39215.1 - 1.9e-27 95.5 14.7 4.3e-27 94.4 14.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Tubulin-binding PF00418.19 PIK39215.1 - 1.1e-21 76.5 20.4 4e-12 45.9 3.1 4.6 4 0 0 4 4 4 3 Tau and MAP protein, tubulin-binding repeat Homeodomain PF00046.29 PIK39216.1 - 0.0018 18.1 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 Homeodomain Kinesin PF00225.23 PIK39217.1 - 4.3e-98 328.3 1.9 7.7e-98 327.5 1.9 1.4 1 0 0 1 1 1 1 Kinesin motor domain MKLP1_Arf_bdg PF16540.5 PIK39217.1 - 1.1e-38 131.6 1.2 2.7e-38 130.3 1.2 1.8 1 0 0 1 1 1 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Microtub_bd PF16796.5 PIK39217.1 - 1.4e-14 54.2 0.7 1.6e-11 44.3 0.0 3.2 3 0 0 3 3 3 2 Microtubule binding DUF4407 PF14362.6 PIK39217.1 - 4.6 6.5 8.9 9.4 5.5 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FA_hydroxylase PF04116.13 PIK39218.1 - 1.7e-27 96.4 10.4 1.7e-27 96.4 10.4 2.3 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily Ank_2 PF12796.7 PIK39219.1 - 9.3e-34 115.9 2.8 1.9e-09 38.0 0.3 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK39219.1 - 4.1e-27 94.2 8.0 2.5e-08 34.3 0.0 5.0 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 PIK39219.1 - 2.1e-21 75.3 3.1 0.0044 17.4 0.0 7.3 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 PIK39219.1 - 4.6e-20 71.4 1.3 1e-05 25.7 0.0 6.4 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK39219.1 - 5.7e-19 66.2 3.6 0.0027 18.1 0.0 7.6 7 0 0 7 7 7 4 Ankyrin repeat TPR_14 PF13428.6 PIK39219.1 - 0.0037 18.0 1.2 0.011 16.5 1.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39219.1 - 0.014 15.2 0.2 0.24 11.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK39219.1 - 0.018 15.1 0.1 0.045 13.9 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39219.1 - 0.053 13.6 0.3 0.18 12.0 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39219.1 - 0.15 11.8 0.1 23 4.8 0.1 2.4 1 1 1 2 2 2 0 TPR repeat AAA_16 PF13191.6 PIK39220.1 - 0.009 16.4 0.0 0.025 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain A_deamin PF02137.18 PIK39222.1 - 7.9e-108 360.8 0.0 1.1e-107 360.3 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 PIK39222.1 - 1.4e-25 89.7 0.4 1.6e-11 44.8 0.0 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK39222.1 - 0.016 15.5 3.0 0.34 11.2 0.3 3.0 2 2 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 TbpB_B_D PF01298.18 PIK39222.1 - 0.031 14.7 0.1 7.2 7.0 0.0 2.4 2 0 0 2 2 2 0 C-lobe and N-lobe beta barrels of Tf-binding protein B WD40 PF00400.32 PIK39223.1 - 6.1e-29 99.7 27.8 8.5e-07 29.6 1.6 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK39223.1 - 2.5e-06 27.7 0.2 0.27 11.6 0.1 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Rav1p_C PF12234.8 PIK39223.1 - 0.04 12.3 0.0 0.48 8.8 0.3 2.1 1 1 0 2 2 2 0 RAVE protein 1 C terminal DUF2756 PF10956.8 PIK39224.1 - 0.00012 22.5 0.0 0.00039 20.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2756) DUF1387 PF07139.11 PIK39224.1 - 0.051 13.3 17.9 0.077 12.7 17.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PPL5 PF18168.1 PIK39224.1 - 0.16 11.3 10.2 0.042 13.1 1.8 2.1 2 0 0 2 2 2 0 Prim-pol family 5 PTPRCAP PF15713.5 PIK39224.1 - 1.3 9.3 9.5 2.2 8.6 0.6 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF4770 PF15994.5 PIK39224.1 - 6.2 7.0 12.2 6.1 7.0 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) PIEZO PF15917.5 PIK39224.1 - 7.8 5.9 9.4 6.6 6.1 1.1 2.2 2 0 0 2 2 2 0 Piezo RNA_polI_A34 PF08208.11 PIK39224.1 - 8.5 6.4 26.9 12 6.0 1.2 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 LicD PF04991.13 PIK39224.1 - 8.6 6.4 11.4 1.1 9.3 4.3 2.0 1 1 0 2 2 2 0 LicD family zf-C3Hc3H PF13891.6 PIK39225.1 - 1e-14 54.6 6.9 2.6e-14 53.3 6.9 1.7 1 0 0 1 1 1 1 Potential DNA-binding domain SecE PF00584.20 PIK39226.1 - 2.4e-16 59.4 0.1 3.6e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex TPK_catalytic PF04263.16 PIK39227.1 - 3.2e-25 88.5 0.0 4.4e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 PIK39227.1 - 7.1e-23 80.1 0.1 1.1e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain PX PF00787.24 PIK39228.1 - 1.5e-17 63.6 0.6 2e-17 63.2 0.6 1.2 1 0 0 1 1 1 1 PX domain Kinesin PF00225.23 PIK39229.1 - 2.1e-77 260.3 3.1 2.1e-77 260.3 3.1 3.8 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 PIK39229.1 - 7.5e-28 97.3 0.2 7.5e-28 97.3 0.2 3.3 3 0 0 3 3 3 1 Microtubule binding Cep57_MT_bd PF06657.13 PIK39230.1 - 0.75 10.3 0.0 0.75 10.3 0.0 9.7 6 4 5 11 11 11 0 Centrosome microtubule-binding domain of Cep57 PIP49_C PF12260.8 PIK39231.1 - 7.8e-20 71.3 0.0 1.6e-19 70.3 0.0 1.5 1 1 0 1 1 1 1 Protein-kinase domain of FAM69 FOXP-CC PF16159.5 PIK39232.1 - 2.2e-34 117.9 2.6 4.9e-34 116.8 2.6 1.6 1 0 0 1 1 1 1 FOXP coiled-coil domain Forkhead PF00250.18 PIK39232.1 - 6.1e-15 55.2 0.0 1.1e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain Zap1_zf2 PF18217.1 PIK39232.1 - 0.014 15.4 0.8 0.014 15.4 0.8 1.8 2 0 0 2 2 2 0 Zap1 zinc finger 2 IBR PF01485.21 PIK39233.1 - 8.7e-12 45.1 16.1 8.5e-09 35.5 11.0 2.5 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain zf-rbx1 PF12678.7 PIK39233.1 - 0.31 11.4 10.0 1.1 9.6 10.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain Pkinase_Tyr PF07714.17 PIK39235.1 - 1.1e-20 74.0 0.0 1.2e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39235.1 - 0.00089 18.7 0.0 0.00091 18.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain RVT_1 PF00078.27 PIK39236.1 - 2.6e-26 92.5 0.0 3e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Xan_ur_permease PF00860.20 PIK39237.1 - 6.6e-54 183.1 23.2 9.9e-28 96.9 6.2 2.1 1 1 1 2 2 2 2 Permease family MFS_MOT1 PF16983.5 PIK39237.1 - 0.47 10.9 10.0 3.8 7.9 2.5 2.8 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily RT_RNaseH_2 PF17919.1 PIK39238.1 - 2.8e-24 85.1 0.0 5.1e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39238.1 - 7.6e-16 58.3 0.1 7.8e-12 45.2 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK39238.1 - 1.1e-11 44.9 0.0 2.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK39238.1 - 2.8e-08 34.2 0.0 7.1e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK39238.1 - 6.6e-05 23.5 0.0 0.00018 22.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Spuma_A9PTase PF03539.14 PIK39238.1 - 0.0038 17.4 0.1 0.019 15.1 0.0 2.1 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) rve PF00665.26 PIK39239.1 - 7.1e-22 77.8 0.1 1.4e-21 76.8 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK39239.1 - 0.00012 21.8 0.6 0.00034 20.3 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Sod_Fe_N PF00081.22 PIK39239.1 - 0.087 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain WSC PF01822.19 PIK39240.1 - 2.1e-15 56.7 21.7 7.1e-09 35.7 4.2 2.2 2 0 0 2 2 2 2 WSC domain Pkinase PF00069.25 PIK39243.1 - 3.3e-14 52.9 0.0 4e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 PIK39243.1 - 0.0044 16.4 0.0 0.0067 15.8 0.0 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK39243.1 - 0.0058 15.5 0.0 0.0071 15.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 PIK39243.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase WSC PF01822.19 PIK39244.1 - 3.6e-16 59.1 23.4 1.5e-11 44.3 8.6 3.2 3 0 0 3 3 3 2 WSC domain AAA_7 PF12775.7 PIK39246.1 - 0.1 12.1 0.4 0.99 8.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cNMP_binding PF00027.29 PIK39247.1 - 1.1e-33 115.1 0.1 7e-20 70.9 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Ion_trans PF00520.31 PIK39247.1 - 2.9e-21 75.8 23.8 3e-15 56.1 18.8 2.1 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 PIK39247.1 - 2.8e-18 65.6 11.6 1.5e-11 44.1 2.2 3.5 4 0 0 4 4 4 2 Ion channel DUF4013 PF13197.6 PIK39247.1 - 0.049 13.5 4.6 0.64 9.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4013) Lig_chan PF00060.26 PIK39247.1 - 0.091 12.6 0.1 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 Ligand-gated ion channel BEN PF10523.9 PIK39248.1 - 0.017 15.4 0.1 0.046 14.0 0.0 1.8 2 0 0 2 2 2 0 BEN domain PNMA PF14893.6 PIK39249.1 - 4e-11 42.9 0.8 5e-11 42.6 0.8 1.1 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK39249.1 - 0.00044 20.5 0.2 0.0077 16.5 0.1 2.5 1 1 1 2 2 2 1 Retrotransposon gag protein DUF5324 PF17258.2 PIK39249.1 - 0.18 11.5 0.2 0.24 11.1 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5324) PHD PF00628.29 PIK39250.1 - 0.0044 16.9 11.4 0.0044 16.9 11.4 2.7 2 1 1 3 3 3 2 PHD-finger DUF3973 PF13119.6 PIK39250.1 - 7.6 6.7 7.4 18 5.5 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3973) HYR PF02494.16 PIK39252.1 - 0.0015 18.8 0.1 0.0043 17.4 0.1 1.8 1 0 0 1 1 1 1 HYR domain NAD_binding_10 PF13460.6 PIK39253.1 - 1.5e-10 41.2 0.0 2.1e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 PIK39253.1 - 1.8e-06 28.4 0.0 3.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 PIK39253.1 - 0.00059 20.0 0.1 0.00093 19.3 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus PH_4 PF15404.6 PIK39253.1 - 0.0077 16.1 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain NmrA PF05368.13 PIK39253.1 - 0.011 15.3 0.1 0.014 15.0 0.1 1.1 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 PIK39253.1 - 0.013 15.0 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK39253.1 - 0.068 13.4 0.0 0.099 12.9 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 PIK39253.1 - 0.15 11.9 0.0 0.37 10.7 0.0 1.6 2 0 0 2 2 2 0 KR domain FPL PF09758.9 PIK39254.1 - 1.5e-61 206.7 12.5 3.2e-61 205.7 12.5 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein G10 PF01125.17 PIK39255.1 - 1.2e-31 109.4 0.4 1.4e-31 109.3 0.4 1.0 1 0 0 1 1 1 1 G10 protein HhH-GPD PF00730.25 PIK39256.1 - 2.4e-18 66.6 0.0 2.7e-17 63.2 0.0 2.1 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 PIK39256.1 - 6.7e-07 28.9 0.0 1.3e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif Peptidase_M10 PF00413.24 PIK39257.1 - 1.8e-38 131.9 0.0 2.8e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK39257.1 - 4e-10 39.5 6.4 2.5e-09 36.9 0.7 3.3 2 1 1 3 3 3 1 Hemopexin PG_binding_1 PF01471.18 PIK39257.1 - 2.8e-08 33.8 0.0 7.7e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 PIK39257.1 - 0.00043 19.9 0.4 0.01 15.5 0.1 2.6 3 0 0 3 3 3 1 Astacin (Peptidase family M12A) Metallopep PF12044.8 PIK39257.1 - 0.0072 15.0 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_4 PF13583.6 PIK39257.1 - 0.03 14.0 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 PIK39257.1 - 0.13 11.1 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 PIK39257.1 - 0.21 12.1 0.2 0.52 10.8 0.2 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK39258.1 - 5.6e-45 153.0 0.0 1e-44 152.2 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK39258.1 - 4.4e-17 61.8 1.9 8e-06 25.7 0.0 4.5 4 0 0 4 4 4 3 Hemopexin DUF4953 PF16313.5 PIK39258.1 - 1.5e-05 24.4 0.1 3.4e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.6 PIK39258.1 - 9.4e-05 22.9 0.1 0.00022 21.7 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PG_binding_1 PF01471.18 PIK39258.1 - 0.0081 16.3 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 PIK39258.1 - 0.013 15.1 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3303 PF11746.8 PIK39258.1 - 0.021 15.1 0.1 0.19 12.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3303) Reprolysin_5 PF13688.6 PIK39258.1 - 0.029 14.5 0.8 0.068 13.3 0.5 1.7 2 0 0 2 2 2 0 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 PIK39258.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M54 WD40 PF00400.32 PIK39259.1 - 0.00015 22.4 1.0 0.4 11.6 0.2 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat VID27 PF08553.10 PIK39259.1 - 0.23 10.5 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Raptor_N PF14538.6 PIK39260.1 - 2.9e-72 241.4 0.0 5.7e-72 240.5 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 PIK39260.1 - 8.4e-12 44.3 0.2 0.00025 21.0 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 PIK39260.1 - 9.7e-09 35.5 0.1 4e-05 23.9 0.0 4.4 3 1 2 5 5 5 3 HEAT repeats Cnd1 PF12717.7 PIK39260.1 - 3.8e-05 23.8 0.0 0.047 13.7 0.0 3.4 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK39260.1 - 0.0028 18.1 1.3 0.085 13.4 0.0 3.4 3 0 0 3 3 3 1 HEAT-like repeat ALF PF03752.13 PIK39260.1 - 0.028 14.4 0.5 5.6 7.0 0.0 3.3 3 0 0 3 3 3 0 Short repeats of unknown function C1_1 PF00130.22 PIK39261.1 - 1e-13 50.9 16.8 2.8e-13 49.5 11.4 2.3 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK39261.1 - 0.15 12.4 7.9 0.35 11.2 7.9 1.7 1 0 0 1 1 1 0 C1 domain PHD_2 PF13831.6 PIK39261.1 - 0.18 11.4 12.9 0.51 9.9 3.7 3.2 3 0 0 3 3 3 0 PHD-finger zf-ACC PF17848.1 PIK39261.1 - 0.21 11.7 8.4 0.4 10.8 0.3 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain RRS1 PF04939.12 PIK39262.1 - 1.2e-58 197.6 5.4 1.2e-58 197.6 5.4 2.4 2 1 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Ribosomal_L18 PF17135.4 PIK39263.1 - 3.4e-64 215.7 0.8 3.7e-64 215.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 PIK39263.1 - 0.054 14.2 0.0 0.085 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A UBA_4 PF14555.6 PIK39264.1 - 8.3e-09 35.1 0.1 1.1e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 PIK39264.1 - 0.001 18.6 0.2 0.0017 18.0 0.2 1.3 1 0 0 1 1 1 1 TAP C-terminal domain Clusterin PF01093.17 PIK39264.1 - 0.075 12.1 0.0 0.081 12.0 0.0 1.0 1 0 0 1 1 1 0 Clusterin Proteasome PF00227.26 PIK39265.1 - 5.8e-38 130.3 4.4 6.9e-31 107.2 0.5 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 PIK39265.1 - 1.3e-14 53.6 0.2 2.2e-14 52.8 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF4259 PF14078.6 PIK39265.1 - 0.14 12.9 2.0 0.24 12.1 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) DHO_dh PF01180.21 PIK39266.1 - 1e-96 323.7 0.0 1.4e-96 323.2 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 PIK39266.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase ADAM_spacer1 PF05986.14 PIK39268.1 - 0.007 16.4 0.1 3.8 7.6 0.0 3.3 1 1 3 4 4 4 1 ADAM-TS Spacer 1 NigD_N PF12667.7 PIK39268.1 - 0.054 13.6 0.0 18 5.5 0.0 3.9 5 0 0 5 5 5 0 NigD-like N-terminal OB domain Soyouz_module PF14313.6 PIK39268.1 - 0.063 13.1 0.0 14 5.6 0.0 2.5 2 0 0 2 2 2 0 N-terminal region of Paramyxovirinae phosphoprotein (P) ADAM_spacer1 PF05986.14 PIK39269.1 - 0.00027 20.9 0.1 1.6 8.8 0.0 3.3 1 1 3 4 4 4 2 ADAM-TS Spacer 1 DUF5356 PF17309.2 PIK39269.1 - 0.0038 17.2 0.0 4 7.4 0.0 3.7 1 1 3 4 4 4 1 Family of unknown function (DUF5356) AMP-binding PF00501.28 PIK39270.1 - 1.2e-104 350.3 0.0 2.3e-104 349.3 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK39270.1 - 0.0008 20.3 0.0 0.0018 19.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SAPS PF04499.15 PIK39270.1 - 9 5.0 11.3 14 4.4 11.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AMP-binding PF00501.28 PIK39271.1 - 5.8e-18 64.7 0.1 7.4e-18 64.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK39271.1 - 0.00058 20.8 0.1 0.0012 19.8 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK39272.1 - 1.2e-22 80.1 0.0 1.4e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme RimK PF08443.11 PIK39272.1 - 0.02 14.5 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Tissue_fac PF01108.17 PIK39273.1 - 0.0005 19.9 0.0 0.0014 18.5 0.0 1.8 2 0 0 2 2 2 1 Tissue factor fn3 PF00041.21 PIK39273.1 - 0.0023 18.3 0.3 0.61 10.5 0.0 2.9 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK39273.1 - 0.052 14.1 0.3 0.17 12.4 0.1 1.9 1 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain RrnaAD PF00398.20 PIK39274.1 - 8.2e-36 123.4 0.0 3.7e-35 121.3 0.0 1.8 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 PIK39274.1 - 5.2e-08 33.5 0.0 1.1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39274.1 - 3.8e-06 27.5 0.0 8.2e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK39274.1 - 3e-05 23.9 0.0 4.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 PIK39274.1 - 3e-05 24.7 0.0 7.7e-05 23.4 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 PIK39274.1 - 0.0031 17.1 0.0 0.0057 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 PIK39274.1 - 0.0035 17.0 0.0 0.0085 15.7 0.0 1.6 2 0 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_18 PF12847.7 PIK39274.1 - 0.0065 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39274.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 PIK39274.1 - 0.017 14.5 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK39274.1 - 0.019 14.8 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 PIK39274.1 - 0.034 13.6 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.6 PIK39274.1 - 0.041 13.7 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 PIK39274.1 - 0.048 12.8 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Met_10 PF02475.16 PIK39274.1 - 0.07 12.9 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Met-10+ like-protein HCNGP PF07818.13 PIK39274.1 - 0.1 13.3 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 HCNGP-like protein PRMT5 PF05185.16 PIK39274.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase ELM2 PF01448.24 PIK39275.1 - 3e-09 37.5 0.1 3e-09 37.5 0.1 2.5 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 PIK39275.1 - 0.00055 20.1 0.4 0.0018 18.4 0.4 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK39275.1 - 0.031 14.2 0.1 0.08 12.8 0.1 1.7 1 0 0 1 1 1 0 Myb DNA-binding like WD40 PF00400.32 PIK39276.1 - 1.5e-09 38.3 2.8 0.014 16.3 0.1 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK39276.1 - 2e-07 31.2 0.1 1.3 9.4 0.0 5.5 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain ELYS-bb PF16687.5 PIK39276.1 - 0.048 12.3 0.0 1.2 7.6 0.0 2.2 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin LRR_4 PF12799.7 PIK39277.1 - 8.2e-13 48.3 14.5 4.6e-05 23.7 0.4 6.8 2 2 6 8 8 8 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK39277.1 - 1e-08 34.5 6.3 0.16 12.1 0.1 6.7 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 PIK39277.1 - 1.1e-06 28.3 9.8 0.66 10.7 0.1 7.1 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.6 PIK39277.1 - 1.6e-06 27.8 16.1 0.15 11.8 0.1 5.8 3 2 3 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 PIK39277.1 - 0.00052 19.6 5.1 0.66 9.4 0.0 3.8 1 1 2 4 4 4 2 Leucine-rich repeat Pentapeptide_4 PF13599.6 PIK39277.1 - 0.096 12.9 0.0 4.7 7.5 0.0 2.9 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) RVT_1 PF00078.27 PIK39278.1 - 2.8e-41 141.4 2.4 4.6e-41 140.7 2.4 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.7 PIK39279.1 - 3.1e-10 39.8 0.1 8.1e-10 38.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK39279.1 - 4.5e-10 39.2 0.0 1.3e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain LRR_9 PF14580.6 PIK39279.1 - 0.0034 16.9 0.1 0.0059 16.1 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat FNIP PF05725.12 PIK39279.1 - 0.029 14.5 1.8 0.065 13.4 1.8 1.6 1 1 0 1 1 1 0 FNIP Repeat RRM_1 PF00076.22 PIK39280.1 - 1.3e-10 41.0 0.0 7e-10 38.6 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 PIK39280.1 - 8.6e-08 31.4 6.6 1.8e-07 30.4 6.6 1.5 1 1 0 1 1 1 1 Zn-finger in Ran binding protein and others DEAD PF00270.29 PIK39282.1 - 2.8e-49 167.3 0.0 8.5e-49 165.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK39282.1 - 5.8e-16 58.8 0.0 1.5e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK39282.1 - 4.4e-06 26.8 0.0 7.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UBA PF00627.31 PIK39282.1 - 0.16 11.9 0.1 3.9 7.5 0.0 2.4 2 0 0 2 2 2 0 UBA/TS-N domain Mur_ligase_C PF02875.21 PIK39283.1 - 0.0098 16.1 0.0 0.037 14.3 0.0 1.9 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mur_ligase_M PF08245.12 PIK39283.1 - 0.077 13.0 0.1 6.7 6.6 0.1 2.4 1 1 0 2 2 2 0 Mur ligase middle domain Nitr_red_assoc PF09655.10 PIK39283.1 - 0.12 13.0 0.1 0.21 12.2 0.1 1.3 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) Homeodomain PF00046.29 PIK39284.1 - 4.4e-21 74.5 4.9 4.4e-21 74.5 4.9 2.1 2 0 0 2 2 2 1 Homeodomain DUF3694 PF12473.8 PIK39286.1 - 4e-24 86.0 0.0 1.5e-23 84.2 0.0 1.9 1 1 0 1 1 1 1 Kinesin protein 7tm_1 PF00001.21 PIK39287.1 - 1.6e-44 152.3 12.3 2.2e-44 151.8 12.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK39287.1 - 4.6e-11 43.0 8.2 1e-10 41.8 4.9 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK39287.1 - 1.1e-08 35.0 14.2 1.1e-08 35.0 14.2 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39287.1 - 1e-07 31.6 14.4 1.8e-07 30.8 14.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ERGIC_N PF13850.6 PIK39287.1 - 1.4 9.3 3.8 1 9.8 1.0 2.3 2 1 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) RabGAP-TBC PF00566.18 PIK39288.1 - 1.2e-27 96.9 5.7 1.2e-27 96.9 5.7 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DivIC PF04977.15 PIK39288.1 - 0.11 12.3 16.0 0.09 12.6 3.1 3.3 2 1 1 3 3 3 0 Septum formation initiator YabA PF06156.13 PIK39288.1 - 3.9 8.2 16.4 0.77 10.4 8.9 2.8 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 PIK39288.1 - 8.6 5.1 25.7 0.6 8.9 2.5 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein GED PF02212.18 PIK39290.1 - 3e-14 52.9 0.5 4.1e-14 52.5 0.5 1.2 1 0 0 1 1 1 1 Dynamin GTPase effector domain Rh5 PF18515.1 PIK39292.1 - 0.028 13.7 0.2 0.94 8.7 0.0 2.1 2 0 0 2 2 2 0 Rh5 coiled-coil domain ZU5 PF00791.20 PIK39293.1 - 7.9e-15 55.0 0.0 1.5e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK39293.1 - 1.6e-10 41.0 0.3 3.2e-10 40.0 0.3 1.5 1 0 0 1 1 1 1 Death domain Death PF00531.22 PIK39295.1 - 1.1e-12 48.0 0.4 2.1e-12 47.0 0.4 1.5 1 0 0 1 1 1 1 Death domain L_HMGIC_fpl PF10242.9 PIK39296.1 - 3.2e-39 135.0 6.6 5e-39 134.4 6.6 1.3 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 PIK39296.1 - 0.00016 21.5 10.7 0.00084 19.2 10.1 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 PIK39296.1 - 0.021 14.7 8.9 0.044 13.6 8.9 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family SSF PF00474.17 PIK39297.1 - 0.0054 15.6 0.5 0.0054 15.6 0.5 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family AAA_6 PF12774.7 PIK39298.1 - 6.1e-155 515.1 0.0 1.7e-154 513.6 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK39298.1 - 2.7e-109 365.9 15.8 8.4e-109 364.3 15.8 1.9 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK39298.1 - 8.6e-87 290.7 0.0 3.6e-86 288.7 0.0 2.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 PIK39298.1 - 2.4e-76 255.3 0.4 9.1e-69 230.6 0.1 3.9 4 0 0 4 4 4 3 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 PIK39298.1 - 2.6e-26 92.2 0.4 1.2e-25 90.0 0.4 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK39298.1 - 6e-26 91.1 0.0 1.2e-11 44.8 0.0 5.5 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 PIK39298.1 - 8.2e-24 83.7 0.2 7.6e-23 80.6 0.0 2.7 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 PIK39298.1 - 9.8e-09 35.8 0.1 0.2 12.0 0.0 4.7 4 0 0 4 4 4 2 AAA ATPase domain AAA_30 PF13604.6 PIK39298.1 - 1.2e-05 25.1 0.3 0.081 12.6 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 PIK39298.1 - 9.8e-05 22.8 0.3 0.23 11.9 0.0 4.6 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK39298.1 - 0.00012 22.6 1.5 1.2 9.7 0.0 4.2 4 0 0 4 4 3 2 AAA domain AAA_22 PF13401.6 PIK39298.1 - 0.00019 21.7 4.5 2.2 8.5 0.0 4.8 6 0 0 6 6 3 2 AAA domain Sigma54_activat PF00158.26 PIK39298.1 - 0.00032 20.5 0.0 0.22 11.2 0.0 3.4 3 0 0 3 3 3 1 Sigma-54 interaction domain ABC_tran PF00005.27 PIK39298.1 - 0.00033 21.2 0.1 4 8.0 0.0 4.5 4 0 0 4 4 4 1 ABC transporter DUF815 PF05673.13 PIK39298.1 - 0.0015 17.8 0.2 5 6.2 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 PIK39298.1 - 0.0062 16.4 0.1 4.1 7.3 0.0 3.2 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 PIK39298.1 - 0.007 16.1 0.2 43 3.9 0.0 3.9 3 0 0 3 3 3 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 PIK39298.1 - 0.0083 16.5 0.1 23 5.4 0.0 3.8 3 0 0 3 3 3 0 RNA helicase Mg_chelatase PF01078.21 PIK39298.1 - 0.026 13.9 2.9 0.93 8.8 0.0 3.8 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 PIK39298.1 - 0.046 13.7 0.0 26 4.7 0.0 3.4 3 0 0 3 3 3 0 Rad17 P-loop domain PhoH PF02562.16 PIK39298.1 - 0.051 13.0 0.3 14 5.1 0.0 3.7 3 0 0 3 3 3 0 PhoH-like protein ABC_tran_CTD PF16326.5 PIK39298.1 - 0.053 13.8 0.4 0.33 11.2 0.2 2.6 2 0 0 2 2 1 0 ABC transporter C-terminal domain AAA_19 PF13245.6 PIK39298.1 - 0.059 13.7 5.3 0.47 10.8 0.0 3.7 4 0 0 4 4 3 0 AAA domain Sigma54_activ_2 PF14532.6 PIK39298.1 - 0.085 13.0 0.1 4.5 7.4 0.0 3.3 4 0 0 4 4 4 0 Sigma-54 interaction domain AAA_25 PF13481.6 PIK39298.1 - 0.12 11.9 1.2 0.96 9.0 0.0 3.0 4 0 0 4 4 3 0 AAA domain TsaE PF02367.17 PIK39298.1 - 0.17 11.9 0.6 21 5.1 0.1 3.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ploopntkinase3 PF18751.1 PIK39298.1 - 0.18 11.7 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_33 PF13671.6 PIK39298.1 - 0.39 10.9 1.7 72 3.5 0.0 4.0 4 0 0 4 4 4 0 AAA domain DUF87 PF01935.17 PIK39298.1 - 0.99 9.4 2.7 8.7 6.4 0.0 3.2 2 0 0 2 2 2 0 Helicase HerA, central domain NACHT PF05729.12 PIK39298.1 - 9.8 6.1 8.9 9.2 6.2 0.0 3.8 5 0 0 5 5 2 0 NACHT domain MT PF12777.7 PIK39299.1 - 4.2e-113 377.9 7.1 5.4e-113 377.5 7.1 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor ApoO PF09769.9 PIK39299.1 - 0.023 14.6 0.1 0.055 13.4 0.0 1.6 2 0 0 2 2 2 0 Apolipoprotein O HAUS6_N PF14661.6 PIK39299.1 - 0.03 13.9 0.4 0.036 13.7 0.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus AAA_lid_1 PF17857.1 PIK39299.1 - 0.031 14.5 0.8 0.055 13.7 0.8 1.4 1 0 0 1 1 1 0 AAA+ lid domain UPF0240 PF06784.11 PIK39299.1 - 0.051 13.6 0.9 0.09 12.8 0.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) DUF2968 PF11180.8 PIK39299.1 - 0.57 9.8 4.6 0.91 9.1 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) UPF0242 PF06785.11 PIK39299.1 - 0.59 10.2 6.2 0.87 9.7 6.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 PIK39299.1 - 0.77 9.1 6.2 1 8.6 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 PIK39299.1 - 0.92 8.3 9.3 1.4 7.7 9.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Spectrin PF00435.21 PIK39299.1 - 1.2 9.7 8.6 0.27 11.7 2.7 2.2 1 1 1 2 2 2 0 Spectrin repeat DUF2570 PF10828.8 PIK39299.1 - 1.7 8.5 7.6 1.8 8.4 5.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) DUF16 PF01519.16 PIK39299.1 - 3.8 8.1 10.0 11 6.5 8.4 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 ABC_tran_CTD PF16326.5 PIK39299.1 - 8.3 6.8 11.5 1 9.7 0.4 2.6 1 1 2 3 3 3 0 ABC transporter C-terminal domain CC2-LZ PF16516.5 PIK39299.1 - 9.1 6.7 13.8 1.4 9.4 4.5 2.9 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Dynein_C PF18199.1 PIK39300.1 - 3.2e-105 351.7 0.3 7.6e-105 350.5 0.3 1.7 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 PIK39300.1 - 5.1e-87 290.6 1.2 8.8e-87 289.8 1.2 1.4 1 0 0 1 1 1 1 ATP-binding dynein motor region MT PF12777.7 PIK39300.1 - 3.7e-52 177.5 0.1 9.5e-52 176.1 0.1 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 PIK39300.1 - 3e-46 157.2 0.0 8.1e-46 155.8 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK39300.1 - 2.6e-37 127.6 0.0 4.1e-35 120.4 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain LprI PF07007.12 PIK39300.1 - 0.038 14.7 0.1 0.16 12.7 0.1 2.1 1 0 0 1 1 1 0 Lysozyme inhibitor LprI ABC2_membrane PF01061.24 PIK39301.1 - 4.3e-24 85.1 17.2 4.3e-24 85.1 17.2 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 PIK39301.1 - 2.9e-07 31.1 0.0 6.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 PIK39301.1 - 0.05 13.4 0.0 0.08 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK39301.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Ldl_recept_a PF00057.18 PIK39302.1 - 6.7e-41 138.2 104.1 1.4e-10 41.2 12.3 8.0 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A 7tm_1 PF00001.21 PIK39302.1 - 3.6e-31 108.5 12.0 5.9e-31 107.8 12.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK39302.1 - 7e-14 51.3 7.2 9.5e-11 41.3 1.0 2.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_5 PF13306.6 PIK39302.1 - 3.8e-05 23.6 2.0 7.3e-05 22.7 0.0 2.4 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK39302.1 - 5.1e-05 23.5 6.0 0.00095 19.5 0.4 3.9 3 1 0 4 4 4 1 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.17 PIK39302.1 - 0.00065 19.1 0.1 0.0012 18.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.6 PIK39302.1 - 0.0068 16.4 4.0 38 4.7 0.0 4.7 4 0 0 4 4 4 0 Leucine Rich repeat Pkinase PF00069.25 PIK39302.1 - 0.0076 15.6 0.2 0.014 14.8 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain LRR_9 PF14580.6 PIK39302.1 - 0.032 13.8 0.2 0.067 12.7 0.2 1.5 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 PIK39302.1 - 1.1 10.0 7.2 26 5.9 0.0 5.1 4 0 0 4 4 4 0 Leucine Rich Repeat CUB PF00431.20 PIK39303.1 - 3.1e-17 62.9 0.1 4.3e-08 33.5 0.0 2.5 2 0 0 2 2 2 2 CUB domain CUB_2 PF02408.20 PIK39303.1 - 1.6e-06 27.8 0.3 0.0026 17.5 0.1 2.3 2 0 0 2 2 2 2 CUB-like domain Lectin_C PF00059.21 PIK39303.1 - 1.9e-05 25.3 1.5 0.038 14.7 0.0 3.4 2 1 1 3 3 3 2 Lectin C-type domain Ldl_recept_a PF00057.18 PIK39304.1 - 2.1e-05 24.6 9.3 2.1e-05 24.6 9.3 2.4 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A DCP1 PF06058.13 PIK39305.1 - 5.1e-18 65.1 0.0 6.3e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family Ion_trans PF00520.31 PIK39306.1 - 1.4e-49 168.6 1.1 1.7e-49 168.3 1.1 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK39306.1 - 0.00061 18.6 10.4 0.003 16.3 1.1 2.4 3 0 0 3 3 3 2 Polycystin cation channel SLATT_6 PF18169.1 PIK39306.1 - 0.034 13.8 2.0 0.33 10.5 0.1 2.2 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 UL42 PF17638.2 PIK39306.1 - 4.6 7.2 5.1 0.71 9.9 0.1 2.0 2 0 0 2 2 2 0 HCMV UL42 Ion_trans PF00520.31 PIK39307.1 - 1.3e-106 355.3 49.6 1.7e-59 201.1 13.9 3.0 3 0 0 3 3 3 3 Ion transport protein PKD_channel PF08016.12 PIK39307.1 - 0.0003 19.6 43.9 0.0004 19.2 5.7 4.9 4 1 1 5 5 5 4 Polycystin cation channel Neurokinin_B PF03823.14 PIK39307.1 - 0.2 11.7 0.5 2.5 8.2 0.0 3.0 2 0 0 2 2 2 0 Neurokinin B Myc_N PF01056.18 PIK39307.1 - 0.45 10.4 8.1 0.66 9.8 8.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region FixH PF05751.11 PIK39307.1 - 2.3 8.2 5.9 8.7 6.4 0.0 3.2 3 0 0 3 3 3 0 FixH DUF4746 PF15928.5 PIK39307.1 - 6.6 6.1 12.3 10 5.4 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1518 PF07469.12 PIK39308.1 - 0.3 11.5 9.1 0.45 10.9 0.7 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF1518) CAC1F_C PF16885.5 PIK39309.1 - 4.6e-07 29.8 0.0 4.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Voltage-gated calcium channel subunit alpha, C-term NACHT PF05729.12 PIK39310.1 - 7.6e-12 45.5 1.1 1.1e-11 44.9 0.3 1.7 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 PIK39310.1 - 2.2e-05 23.8 0.7 3.6e-05 23.1 0.7 1.3 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.12 PIK39311.1 - 0.00055 19.9 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF1857 PF08982.11 PIK39311.1 - 0.0056 16.5 0.1 0.38 10.6 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1857) AAA_25 PF13481.6 PIK39311.1 - 0.0077 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK39311.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK39311.1 - 0.0086 16.5 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 PIK39311.1 - 0.0093 16.5 0.0 0.51 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain DAP3 PF10236.9 PIK39311.1 - 0.016 14.4 0.1 0.36 9.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ATPase PF06745.13 PIK39311.1 - 0.021 14.2 0.0 0.054 12.8 0.0 1.6 2 0 0 2 2 2 0 KaiC AAA_22 PF13401.6 PIK39311.1 - 0.13 12.5 0.0 0.55 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK39311.1 - 0.18 12.0 0.1 0.51 10.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain Methyltransf_8 PF05148.15 PIK39312.1 - 4.6e-71 239.2 0.1 7.4e-71 238.5 0.1 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 PIK39312.1 - 1.2e-08 35.5 0.0 6.1e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39312.1 - 1.1e-05 26.0 0.0 0.0013 19.3 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK39312.1 - 0.0027 17.5 0.0 0.3 10.8 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39312.1 - 0.0029 17.5 0.0 0.014 15.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK39312.1 - 0.004 16.7 0.0 0.28 10.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 PIK39312.1 - 0.0052 16.1 0.1 0.025 13.9 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK39312.1 - 0.0094 16.7 1.1 0.42 11.4 0.0 3.6 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_32 PF13679.6 PIK39312.1 - 6.1 6.8 0.0 6.1 6.8 0.0 3.2 2 1 0 2 2 2 0 Methyltransferase domain Peptidase_C1 PF00112.23 PIK39313.1 - 3.4e-41 141.7 0.6 3.9e-41 141.5 0.6 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 PIK39313.1 - 0.0014 17.5 0.2 0.11 11.2 0.3 2.0 2 0 0 2 2 2 2 Peptidase C1-like family I-set PF07679.16 PIK39314.1 - 7.3e-11 42.0 0.5 1.8e-08 34.3 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK39314.1 - 2.8e-10 40.6 6.4 2.8e-08 34.2 0.1 3.5 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK39314.1 - 1.2e-08 35.0 0.5 8.9e-08 32.3 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK39314.1 - 4.4e-07 30.0 1.4 1.4e-05 25.1 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK39314.1 - 0.0011 18.9 1.8 0.084 13.0 0.6 3.1 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK39314.1 - 0.0018 18.6 4.9 0.009 16.3 0.1 3.8 3 3 0 3 3 3 1 Immunoglobulin domain Ig_6 PF18452.1 PIK39314.1 - 0.11 12.0 0.0 0.33 10.6 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 PIK39315.1 - 4e-13 49.3 2.7 6.5e-08 32.7 0.4 3.4 2 1 1 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK39315.1 - 6e-12 46.0 1.1 7e-07 29.8 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK39315.1 - 3.4e-10 40.1 1.4 0.00021 21.6 0.1 3.4 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK39315.1 - 1.6e-09 37.7 0.6 1.1e-07 31.8 0.1 3.1 3 1 0 3 3 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK39315.1 - 8.2e-09 35.6 1.9 1.6e-07 31.4 0.2 3.0 2 1 1 3 3 3 1 Immunoglobulin V-set domain UPF0242 PF06785.11 PIK39315.1 - 0.00022 21.4 3.6 0.00033 20.8 3.6 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF3552 PF12072.8 PIK39315.1 - 0.00026 20.5 6.9 0.00039 19.9 6.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Collectrin PF16959.5 PIK39315.1 - 0.0067 16.2 0.1 0.015 15.1 0.1 1.6 1 0 0 1 1 1 1 Renal amino acid transporter RIC3 PF15361.6 PIK39315.1 - 0.0093 16.4 3.3 0.0093 16.4 3.3 2.2 1 1 1 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 LYRIC PF15686.5 PIK39315.1 - 0.0099 15.5 1.1 0.014 15.0 1.1 1.2 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family C2-set_2 PF08205.12 PIK39315.1 - 0.013 15.6 0.5 0.046 13.8 0.1 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK39315.1 - 0.018 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain NLE PF08154.12 PIK39315.1 - 0.03 14.9 0.4 0.59 10.7 0.3 2.6 2 0 0 2 2 2 0 NLE (NUC135) domain BatD PF13584.6 PIK39315.1 - 0.038 12.8 0.0 0.37 9.6 0.0 2.1 2 0 0 2 2 2 0 Oxygen tolerance DUF3281 PF11685.8 PIK39315.1 - 0.039 13.3 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3281) Mem_trans PF03547.18 PIK39315.1 - 0.049 12.0 0.1 0.065 11.6 0.1 1.2 1 0 0 1 1 1 0 Membrane transport protein Chi-conotoxin PF16981.5 PIK39315.1 - 0.1 12.8 0.0 0.4 10.9 0.0 2.0 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily SID-1_RNA_chan PF13965.6 PIK39315.1 - 0.14 10.5 1.7 0.2 10.1 1.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2140 PF09911.9 PIK39315.1 - 0.15 11.6 0.2 0.34 10.4 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) CALCOCO1 PF07888.11 PIK39315.1 - 0.17 10.7 12.4 0.24 10.2 12.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GRIM-19 PF06212.12 PIK39315.1 - 0.21 11.6 0.3 0.36 10.8 0.3 1.3 1 0 0 1 1 1 0 GRIM-19 protein MAP17 PF15807.5 PIK39315.1 - 0.25 11.6 2.4 0.26 11.5 1.5 1.5 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Spc7 PF08317.11 PIK39315.1 - 0.26 10.1 13.0 0.41 9.5 13.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 PIK39315.1 - 0.42 9.7 9.2 0.61 9.1 9.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CC2-LZ PF16516.5 PIK39315.1 - 0.61 10.5 10.8 0.075 13.4 3.6 2.6 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF2681 PF10883.8 PIK39315.1 - 0.61 10.5 5.1 0.89 10.0 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Jnk-SapK_ap_N PF09744.9 PIK39315.1 - 1.2 9.3 13.7 1.5 9.1 13.0 1.5 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 PIK39315.1 - 1.3 8.5 12.2 2 7.8 12.2 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Rho_Binding PF08912.11 PIK39315.1 - 1.5 9.7 12.1 3 8.7 2.9 2.6 1 1 1 2 2 2 0 Rho Binding Tropomyosin_1 PF12718.7 PIK39315.1 - 2.9 8.0 18.2 12 6.1 17.6 1.9 1 1 0 1 1 1 0 Tropomyosin like A_deaminase PF00962.22 PIK39316.1 - 9.6e-106 353.8 0.0 1.7e-105 353.0 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase EamA PF00892.20 PIK39318.1 - 2.9e-19 69.6 31.0 2.1e-16 60.3 18.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family Ribosomal_S25 PF03297.15 PIK39319.1 - 2.3e-36 124.0 3.2 2.9e-36 123.7 3.2 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Fe_dep_repress PF01325.19 PIK39319.1 - 0.093 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain mTERF PF02536.14 PIK39320.1 - 4e-17 62.1 0.0 7.3e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 mTERF Strabismus PF06638.11 PIK39321.1 - 8.9e-82 275.3 1.1 1.1e-81 275.1 1.1 1.0 1 0 0 1 1 1 1 Strabismus protein TraQ PF09679.10 PIK39321.1 - 0.29 11.1 4.3 0.51 10.3 4.3 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) Strabismus PF06638.11 PIK39322.1 - 4.7e-164 546.8 1.3 1e-135 453.3 0.4 2.1 2 0 0 2 2 2 2 Strabismus protein Presenilin PF01080.17 PIK39322.1 - 0.13 11.0 2.8 0.2 10.4 2.8 1.3 1 0 0 1 1 1 0 Presenilin ORC6 PF05460.13 PIK39322.1 - 0.58 9.4 9.2 0.96 8.6 9.2 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF5423 PF17461.2 PIK39322.1 - 0.61 8.9 9.5 1 8.1 9.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Ig_3 PF13927.6 PIK39323.1 - 5.1e-15 55.8 0.6 1.7e-10 41.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK39323.1 - 5.9e-13 48.8 0.7 4.6e-08 33.1 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK39323.1 - 5.9e-13 48.7 0.6 2.2e-08 34.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK39323.1 - 1.4e-09 38.1 0.7 3.5e-05 24.1 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK39323.1 - 4.9e-06 26.7 1.1 0.11 12.7 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK39323.1 - 1.2e-05 25.3 0.1 0.15 12.2 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK39323.1 - 0.00019 21.6 0.4 0.93 9.8 0.1 2.9 2 1 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK39323.1 - 0.00022 20.7 0.6 0.58 9.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK39324.1 - 2.7e-14 53.5 0.0 2.3e-09 37.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK39324.1 - 5.2e-13 48.9 0.0 3.7e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK39324.1 - 6.3e-13 48.7 0.1 2.6e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK39324.1 - 1.2e-08 35.2 0.0 0.00014 22.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK39324.1 - 2e-06 28.0 0.4 0.0058 16.8 0.0 3.1 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK39324.1 - 4.7e-06 26.1 0.2 0.028 14.0 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ly-6_related PF06579.12 PIK39324.1 - 0.064 13.5 3.7 0.85 9.9 3.7 2.5 1 1 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein Transglut_core PF01841.19 PIK39326.1 - 3.8e-07 30.5 0.0 7.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 PIK39326.1 - 0.086 12.4 0.2 2.3 7.7 0.2 2.5 1 1 0 1 1 1 0 Transglutaminase-like domain Macoilin PF09726.9 PIK39327.1 - 2.3 6.7 8.9 2.5 6.5 8.9 1.1 1 0 0 1 1 1 0 Macoilin family Dicty_CAR PF05462.11 PIK39328.1 - 5.9e-13 48.6 18.9 7.9e-13 48.2 18.9 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 PIK39328.1 - 9.2e-09 34.9 18.6 1.3e-08 34.5 18.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPR_Gpa2_C PF11970.8 PIK39328.1 - 1.6e-06 28.1 1.2 1.6e-06 28.1 1.2 2.4 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term GTA_holin_3TM PF11351.8 PIK39328.1 - 0.029 14.9 1.8 0.058 13.9 1.8 1.6 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Frizzled PF01534.17 PIK39328.1 - 1.9 7.4 26.0 0.043 12.9 10.9 2.1 1 1 1 2 2 2 0 Frizzled/Smoothened family membrane region DUF4131 PF13567.6 PIK39328.1 - 9.6 5.8 8.8 2.4 7.8 1.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) RhoGAP PF00620.27 PIK39329.1 - 5.4e-41 139.9 0.3 1.1e-40 138.9 0.2 1.6 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 PIK39329.1 - 2.1e-29 102.5 1.9 7e-29 100.8 0.3 2.2 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 PIK39329.1 - 1.2e-05 25.1 0.2 2.9e-05 23.8 0.2 1.7 1 1 0 1 1 1 1 CRAL/TRIO domain TPR_12 PF13424.6 PIK39330.1 - 7e-20 71.1 12.9 3.2e-06 27.3 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat Rapsyn_N PF10579.9 PIK39330.1 - 5.4e-17 61.7 0.7 8.9e-14 51.3 0.2 2.9 2 0 0 2 2 2 2 Rapsyn N-terminal myristoylation and linker region TPR_MalT PF17874.1 PIK39330.1 - 3.8e-14 52.8 7.2 7.4e-11 42.0 1.4 2.9 1 1 2 3 3 3 3 MalT-like TPR region TPR_2 PF07719.17 PIK39330.1 - 5.6e-10 38.6 17.4 0.037 14.1 0.1 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39330.1 - 7.5e-09 35.1 4.2 0.0019 18.3 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39330.1 - 8.9e-08 32.3 6.8 0.81 10.7 0.1 6.5 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK39330.1 - 2.6e-07 31.1 7.3 0.065 13.9 0.5 5.6 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39330.1 - 3.4e-07 29.8 5.8 3.8 7.8 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39330.1 - 9.3e-05 22.1 6.7 0.28 11.1 0.0 5.9 7 0 0 7 7 7 1 Tetratricopeptide repeat zf-RING_11 PF17123.5 PIK39330.1 - 0.00031 20.4 3.5 0.00085 19.0 3.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger TPR_10 PF13374.6 PIK39330.1 - 0.00036 20.3 9.8 2.6 8.1 0.4 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK39330.1 - 0.00075 19.3 6.9 0.23 11.2 0.4 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 PIK39330.1 - 0.013 15.7 9.2 1.2 9.4 0.1 3.7 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK39330.1 - 0.019 15.4 10.7 3 8.4 0.2 4.6 2 2 1 4 4 4 0 Tetratricopeptide repeat zf-RING_5 PF14634.6 PIK39330.1 - 0.03 14.3 3.4 0.071 13.1 3.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 PIK39330.1 - 0.037 14.4 2.9 0.094 13.1 2.9 1.7 1 0 0 1 1 1 0 Ring finger domain DUF3856 PF12968.7 PIK39330.1 - 0.085 12.9 2.6 3 7.9 0.7 3.7 2 1 2 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.6 PIK39330.1 - 0.11 13.1 8.3 41 5.1 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK39330.1 - 0.12 12.5 3.0 18 5.5 0.3 3.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat BTB PF00651.31 PIK39331.1 - 2e-17 63.4 0.0 6.3e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 PIK39331.1 - 1.5e-08 34.6 0.1 2.7e-06 27.4 0.1 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch DUF5465 PF17553.2 PIK39331.1 - 0.59 10.8 5.7 2.2 9.0 5.7 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5465) EAP30 PF04157.16 PIK39332.1 - 8.5e-71 238.0 0.5 9.6e-71 237.8 0.5 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Phage_Mu_Gam PF07352.12 PIK39332.1 - 0.036 14.0 2.8 0.082 12.8 2.8 1.6 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein LcrG PF07216.12 PIK39332.1 - 0.094 12.6 0.3 4.2 7.4 0.0 2.5 1 1 1 2 2 2 0 LcrG protein Ribosomal_L29e PF01779.17 PIK39332.1 - 0.16 12.3 0.8 0.74 10.2 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L29e protein family adh_short PF00106.25 PIK39333.1 - 5.8e-27 94.4 0.1 9.8e-20 70.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39333.1 - 3.9e-20 72.4 0.0 1.4e-15 57.5 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39333.1 - 5.9e-07 29.6 0.0 1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK39333.1 - 0.0052 16.3 0.1 0.021 14.3 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 PIK39334.1 - 7.7e-23 81.0 0.0 1.9e-17 63.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39334.1 - 2e-17 63.6 0.0 3.6e-13 49.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39334.1 - 1.7e-06 28.1 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_8 PF13450.6 PIK39335.1 - 2e-13 50.4 0.5 3.8e-13 49.4 0.5 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 PIK39335.1 - 2.9e-13 49.9 0.0 1e-12 48.1 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 PIK39335.1 - 1.2e-10 41.1 1.8 7e-06 25.4 1.2 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 PIK39335.1 - 2.8e-05 23.9 1.6 0.057 13.0 0.6 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase GDI PF00996.18 PIK39335.1 - 0.00035 19.2 0.2 0.12 10.9 0.1 2.2 2 0 0 2 2 2 2 GDP dissociation inhibitor FAD_oxidored PF12831.7 PIK39335.1 - 0.00046 19.7 0.2 0.01 15.2 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 PIK39335.1 - 0.0037 16.5 1.4 0.0044 16.3 0.2 1.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 PIK39335.1 - 0.007 15.6 1.2 0.011 15.1 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 PIK39335.1 - 0.0071 16.9 0.9 0.08 13.5 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK39335.1 - 0.0073 15.6 0.3 0.019 14.2 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK39335.1 - 0.033 13.4 1.1 0.061 12.6 1.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK39335.1 - 0.13 10.9 1.6 0.73 8.5 2.3 1.8 3 0 0 3 3 3 0 HI0933-like protein MCRA PF06100.11 PIK39335.1 - 0.25 10.1 0.2 0.36 9.6 0.2 1.2 1 0 0 1 1 1 0 MCRA family 7tm_1 PF00001.21 PIK39336.1 - 1.1e-32 113.5 16.7 1.3e-32 113.2 16.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39336.1 - 4.4e-12 46.2 18.3 6.5e-12 45.6 18.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK39336.1 - 3.6e-07 29.8 8.4 3.6e-07 29.8 8.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK39336.1 - 1.8e-06 27.9 12.5 4.3e-06 26.7 12.5 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK39336.1 - 0.00054 19.6 8.2 0.0012 18.4 8.2 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Cytochrom_NNT PF03264.14 PIK39336.1 - 0.14 11.9 3.0 0.28 10.9 0.8 2.4 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Reeler PF02014.16 PIK39337.1 - 0.00019 22.2 0.0 0.0002 22.1 0.0 1.0 1 0 0 1 1 1 1 Reeler domain Fringe PF02434.16 PIK39338.1 - 8e-09 35.3 0.4 5.2e-08 32.6 0.4 1.9 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 PIK39338.1 - 9.7e-05 22.3 0.2 0.0027 17.5 0.1 2.2 1 1 1 2 2 2 1 Galactosyltransferase Glyco_trans_2_3 PF13632.6 PIK39338.1 - 0.0005 20.0 0.5 0.0014 18.6 0.4 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 PIK39338.1 - 0.0047 16.4 0.4 5.7 6.4 0.0 2.8 2 1 1 3 3 3 2 Glycosyl transferase family 21 Cytochrom_C PF00034.21 PIK39339.1 - 1.9e-08 35.3 0.7 3.5e-08 34.5 0.7 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 PIK39339.1 - 2e-05 24.8 1.9 6.3e-05 23.2 1.9 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C1 PF02167.15 PIK39339.1 - 0.085 12.6 0.0 0.82 9.4 0.0 2.0 2 0 0 2 2 2 0 Cytochrome C1 family 7tm_1 PF00001.21 PIK39340.1 - 5.3e-17 62.0 8.3 5.3e-17 62.0 8.3 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39340.1 - 7e-07 29.1 11.2 8.5e-07 28.9 11.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39340.1 - 0.00011 21.7 4.2 0.00014 21.4 4.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK39340.1 - 0.00021 21.2 3.9 0.00027 20.8 3.9 1.1 1 0 0 1 1 1 1 Olfactory receptor HCO3_cotransp PF00955.21 PIK39341.1 - 1.4e-211 703.8 12.6 1.9e-211 703.3 12.6 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 PIK39341.1 - 2.4e-69 234.2 4.6 4.6e-46 157.8 0.0 2.3 1 1 1 2 2 2 2 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.22 PIK39341.1 - 0.15 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 CWC25 PF12542.8 PIK39342.1 - 3e-16 60.2 3.2 3e-16 60.2 3.2 3.7 2 2 0 2 2 2 1 Pre-mRNA splicing factor DUF755 PF05501.11 PIK39342.1 - 0.0096 16.2 13.8 0.0096 16.2 13.8 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF755) Retrotran_gag_2 PF14223.6 PIK39344.1 - 0.0003 20.5 2.9 0.00061 19.5 2.9 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type ASL_C PF08328.11 PIK39344.1 - 0.037 14.1 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DUF2524 PF10732.9 PIK39344.1 - 9.4 6.6 9.9 1.1 9.6 1.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2524) RVT_2 PF07727.14 PIK39346.1 - 8.1e-16 58.4 1.0 4.5e-11 42.9 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK39346.1 - 3.9e-10 40.0 0.0 8.2e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK39346.1 - 0.0034 17.1 0.0 0.093 12.5 0.0 2.7 2 1 0 2 2 2 1 Integrase core domain DDE_3 PF13358.6 PIK39346.1 - 0.016 15.0 0.0 0.039 13.7 0.0 1.7 1 1 0 1 1 1 0 DDE superfamily endonuclease RVT_1 PF00078.27 PIK39347.1 - 6.2e-08 32.4 0.0 1.5e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK39347.1 - 2.9e-05 24.3 0.1 0.00031 21.0 0.2 2.3 2 0 0 2 2 2 1 GIY-YIG catalytic domain Transposase_21 PF02992.14 PIK39348.1 - 2.3e-09 36.8 0.0 3.4e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Transposase family tnp2 DUF3119 PF11317.8 PIK39348.1 - 0.17 12.2 0.7 0.32 11.3 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) BEN PF10523.9 PIK39349.1 - 2.2e-10 40.6 0.1 4.9e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 BEN domain DUF4543 PF15076.6 PIK39349.1 - 0.13 12.4 1.9 17 5.6 0.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4543) HTH_Bact PF18768.1 PIK39350.1 - 0.086 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix bacterial domain DUF4218 PF13960.6 PIK39350.1 - 0.17 11.5 1.1 0.38 10.4 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) RVT_1 PF00078.27 PIK39351.1 - 8e-16 58.2 0.1 1.4e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK39351.1 - 0.36 11.0 3.1 0.87 9.8 3.1 1.7 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 PIK39352.1 - 4.5e-08 32.9 0.0 7.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK39354.1 - 8.2e-20 70.7 0.8 1.4e-19 69.9 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK39354.1 - 1.1e-09 38.5 0.0 2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK39354.1 - 0.01 16.0 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK39356.1 - 1.3e-26 92.5 0.0 3.2e-26 91.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39356.1 - 6e-19 68.5 0.1 1.7e-18 67.0 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK39356.1 - 5.2e-14 52.4 0.0 1.3e-13 51.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase ERp29 PF07749.12 PIK39356.1 - 0.15 13.0 0.5 0.55 11.2 0.0 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain SAND PF01342.21 PIK39357.1 - 1.6e-06 27.7 0.0 2.2 8.0 0.0 3.4 3 0 0 3 3 3 3 SAND domain UPF0242 PF06785.11 PIK39357.1 - 0.00017 21.8 9.1 0.00023 21.4 9.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF443 PF04276.12 PIK39357.1 - 0.0069 16.2 1.1 0.012 15.4 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF443) HemX PF04375.14 PIK39357.1 - 0.011 15.0 7.8 0.015 14.6 7.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4888 PF16229.5 PIK39357.1 - 0.012 15.6 0.1 29 4.6 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4888) Macoilin PF09726.9 PIK39357.1 - 0.018 13.6 5.5 0.022 13.3 5.7 1.3 1 1 0 1 1 1 0 Macoilin family SID-1_RNA_chan PF13965.6 PIK39357.1 - 0.02 13.3 2.6 0.025 13.0 2.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LST1 PF05083.13 PIK39357.1 - 0.021 15.1 0.2 0.037 14.3 0.2 1.4 1 0 0 1 1 1 0 LST-1 protein Tmemb_9 PF05434.11 PIK39357.1 - 0.027 14.4 5.9 0.066 13.1 5.9 1.7 1 0 0 1 1 1 0 TMEM9 IstB_IS21_ATP PF08483.11 PIK39357.1 - 0.028 14.3 1.3 57 3.7 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding N-terminal PspB PF06667.12 PIK39357.1 - 0.032 14.3 1.3 0.032 14.3 1.3 2.0 2 1 1 3 3 2 0 Phage shock protein B COX2_TM PF02790.15 PIK39357.1 - 0.033 14.3 0.5 0.06 13.5 0.5 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3810 PF12725.7 PIK39357.1 - 0.035 13.4 0.6 0.13 11.6 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) MLANA PF14991.6 PIK39357.1 - 0.036 14.3 1.6 0.084 13.2 1.6 1.6 1 1 0 1 1 1 0 Protein melan-A V_ATPase_I PF01496.19 PIK39357.1 - 0.05 11.5 4.5 0.066 11.1 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC2_membrane_3 PF12698.7 PIK39357.1 - 0.071 12.2 0.1 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4446 PF14584.6 PIK39357.1 - 0.085 12.8 7.6 0.076 13.0 6.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) Wzy_C PF04932.15 PIK39357.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 O-Antigen ligase FtsH_ext PF06480.15 PIK39357.1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 FtsH Extracellular NEMP PF10225.9 PIK39357.1 - 0.18 11.5 0.4 0.25 11.0 0.4 1.1 1 0 0 1 1 1 0 NEMP family CLN3 PF02487.17 PIK39357.1 - 0.18 10.8 1.9 0.27 10.3 1.9 1.2 1 0 0 1 1 1 0 CLN3 protein Peptidase_S49_N PF08496.10 PIK39357.1 - 0.24 11.4 6.3 0.43 10.6 6.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal O-antigen_lig PF13425.6 PIK39357.1 - 0.26 10.0 5.0 0.37 9.5 5.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4834 PF16118.5 PIK39357.1 - 0.32 12.0 5.4 0.79 10.7 5.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Phage_Gp23 PF10669.9 PIK39357.1 - 1 9.7 9.0 1.9 8.8 9.0 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Ly49 PF08391.10 PIK39357.1 - 1.4 9.3 10.3 2.9 8.3 10.3 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region HU-CCDC81_bac_2 PF18175.1 PIK39357.1 - 4.1 7.3 7.7 5.7 6.9 1.5 2.6 1 1 1 2 2 2 0 CCDC81-like prokaryotic HU domain 2 MAP17 PF15807.5 PIK39357.1 - 9.7 6.4 9.1 21 5.3 9.1 1.6 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SHMT PF00464.19 PIK39358.1 - 5.9e-117 390.6 0.1 1.5e-115 386.1 0.1 2.0 1 1 0 1 1 1 1 Serine hydroxymethyltransferase DUF1104 PF06518.11 PIK39358.1 - 0.028 14.8 0.9 0.26 11.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Aminotran_1_2 PF00155.21 PIK39358.1 - 0.03 13.5 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II I-set PF07679.16 PIK39359.1 - 0.075 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 PIK39359.1 - 0.094 12.9 0.1 0.23 11.6 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK39359.1 - 0.18 12.0 0.1 0.38 10.9 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK39360.1 - 1.7e-25 89.8 0.0 2.4e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39360.1 - 2.7e-19 69.5 0.0 4e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK39360.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pyrid_ox_like PF16242.5 PIK39360.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like Pkinase_Tyr PF07714.17 PIK39361.1 - 1.9e-26 92.9 0.0 2.3e-26 92.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39361.1 - 4e-21 75.6 0.0 4.3e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain GIY-YIG PF01541.24 PIK39363.1 - 0.063 13.6 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 GIY-YIG catalytic domain AAA_30 PF13604.6 PIK39363.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain UQ_con PF00179.26 PIK39365.1 - 1.4e-18 66.9 2.2 1.4e-18 66.9 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Vps36-NZF-N PF16988.5 PIK39365.1 - 0.017 14.5 1.0 0.038 13.4 0.1 2.1 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Prok-E2_B PF14461.6 PIK39365.1 - 0.086 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B SAPS PF04499.15 PIK39365.1 - 0.1 11.4 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SPX PF03105.19 PIK39365.1 - 0.27 11.1 9.9 0.38 10.6 9.9 1.1 1 0 0 1 1 1 0 SPX domain SPATIAL PF15256.6 PIK39365.1 - 0.5 10.7 4.2 0.5 10.7 0.4 2.1 2 0 0 2 2 2 0 SPATIAL Smim3 PF17307.2 PIK39365.1 - 0.9 9.1 3.1 0.74 9.3 1.1 1.8 2 0 0 2 2 2 0 Small integral membrane protein 3 Methyltr_RsmB-F PF01189.17 PIK39366.1 - 4.5e-17 62.3 0.1 1.6e-16 60.5 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F DUF1296 PF06972.11 PIK39366.1 - 0.077 13.2 0.6 16 5.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) YccV-like PF08755.11 PIK39367.1 - 3.7e-10 40.2 1.7 4.2e-10 40.0 0.4 1.7 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like DUF3139 PF11337.8 PIK39367.1 - 0.042 14.5 0.2 0.07 13.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Lipoprotein_Ltp PF07553.11 PIK39367.1 - 0.46 10.8 3.3 1.4 9.3 0.4 2.4 2 0 0 2 2 2 0 Host cell surface-exposed lipoprotein Glyco_hydro_47 PF01532.20 PIK39368.1 - 1.1e-157 525.6 0.7 1.4e-157 525.3 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 YchF-GTPase_C PF06071.13 PIK39368.1 - 0.094 12.9 0.6 0.31 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF933) Ribosomal_S9 PF00380.19 PIK39369.1 - 9.4e-21 74.6 0.0 1.8e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF2887 PF11103.8 PIK39369.1 - 0.0077 16.3 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2887) LepA_C PF06421.12 PIK39369.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus DUF832 PF05734.11 PIK39370.1 - 0.041 13.4 0.3 0.049 13.1 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) DUF3095 PF11294.8 PIK39370.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) Sulf_transp PF04143.14 PIK39371.1 - 1.4e-36 126.6 36.8 2.7e-34 119.1 36.8 2.1 1 1 0 1 1 1 1 Sulphur transport DUF4516 PF14990.6 PIK39371.1 - 1 9.1 3.3 3.5 7.4 3.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4516) Fcf2 PF08698.11 PIK39372.1 - 1.7e-36 124.5 1.2 1.7e-36 124.5 1.2 2.7 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing EGF PF00008.27 PIK39373.1 - 9e-26 89.8 45.2 3.1e-10 40.2 9.5 3.7 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 PIK39373.1 - 5.8e-19 68.0 38.4 4.9e-07 30.2 7.4 4.7 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK39373.1 - 6.6e-10 39.2 44.7 6.4e-05 23.2 10.0 3.6 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 PIK39373.1 - 3.9e-09 36.6 47.2 6.3e-05 23.1 10.1 3.4 3 0 0 3 3 3 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK39373.1 - 7.4e-07 29.3 36.2 0.00098 19.4 9.0 3.6 1 1 2 3 3 3 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK39373.1 - 2e-05 24.7 36.5 0.017 15.3 5.6 3.8 2 1 1 3 3 3 3 EGF domain Laminin_EGF PF00053.24 PIK39373.1 - 0.0036 17.4 34.3 0.13 12.5 6.7 3.4 1 1 2 3 3 3 2 Laminin EGF domain Plasmod_Pvs28 PF06247.11 PIK39373.1 - 0.0038 17.5 29.7 0.026 14.8 6.3 3.7 3 2 0 3 3 3 2 Pvs28 EGF domain cEGF PF12662.7 PIK39373.1 - 0.011 15.7 4.6 0.011 15.7 4.6 5.5 4 3 0 4 4 4 0 Complement Clr-like EGF-like EGF PF00008.27 PIK39374.1 - 5.1e-85 279.3 163.0 2.8e-08 33.9 8.9 12.5 12 0 0 12 12 12 12 EGF-like domain hEGF PF12661.7 PIK39374.1 - 1.4e-47 158.8 151.3 8.2e-07 29.4 7.5 14.4 14 0 0 14 14 14 12 Human growth factor-like EGF EGF_CA PF07645.15 PIK39374.1 - 9e-24 83.4 188.6 0.00085 19.5 10.8 12.4 7 3 5 12 12 12 10 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39374.1 - 7.3e-16 58.1 158.9 0.0069 16.5 6.6 13.2 7 3 5 12 12 12 10 EGF domain EGF_2 PF07974.13 PIK39374.1 - 6.3e-10 39.3 180.9 0.014 15.8 9.4 12.5 12 0 0 12 12 12 10 EGF-like domain FXa_inhibition PF14670.6 PIK39374.1 - 0.0068 16.7 151.0 0.74 10.1 3.3 12.7 2 2 9 11 11 11 7 Coagulation Factor Xa inhibitory site RPN7 PF10602.9 PIK39375.1 - 1.6e-48 164.7 0.9 3.2e-48 163.7 0.9 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 PIK39375.1 - 4.7e-17 62.4 0.3 1.1e-16 61.2 0.3 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 PIK39375.1 - 0.00011 22.1 1.9 0.018 15.1 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39375.1 - 0.0069 16.2 3.9 0.029 14.2 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39375.1 - 0.024 14.3 0.0 0.073 12.8 0.0 1.9 1 0 0 1 1 1 0 TPR repeat TPR_12 PF13424.6 PIK39375.1 - 0.087 13.1 0.1 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39375.1 - 0.098 12.9 1.2 3 8.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK39375.1 - 0.12 13.1 0.1 4.4 8.0 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Homeodomain PF00046.29 PIK39376.1 - 1.8e-17 62.9 5.0 1.4e-12 47.2 1.1 3.4 3 0 0 3 3 3 2 Homeodomain CUT PF02376.15 PIK39376.1 - 5.2e-10 39.4 0.3 1.8e-09 37.6 0.3 2.0 1 0 0 1 1 1 1 CUT domain Homeobox_KN PF05920.11 PIK39376.1 - 2.9e-05 23.9 0.0 0.092 12.7 0.1 2.8 2 0 0 2 2 2 2 Homeobox KN domain HTH_31 PF13560.6 PIK39376.1 - 0.0017 18.7 0.0 0.018 15.4 0.0 2.7 4 0 0 4 4 4 1 Helix-turn-helix domain HNF-1_N PF04814.13 PIK39376.1 - 0.02 15.5 0.0 0.02 15.5 0.0 2.8 2 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homez PF11569.8 PIK39376.1 - 0.032 13.7 0.2 1 8.9 0.0 2.5 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 PIK39376.1 - 0.096 12.6 0.2 15 5.5 0.0 2.7 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT NUDIX PF00293.28 PIK39377.1 - 8.2e-13 48.5 0.2 1e-12 48.2 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain Neur_chan_memb PF02932.16 PIK39378.1 - 0.11 12.6 11.6 0.28 11.2 11.5 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Galactosyl_T PF01762.21 PIK39379.1 - 2.4e-30 105.8 0.4 2.8e-30 105.6 0.4 1.0 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK39379.1 - 1.3e-06 28.1 0.1 1.6e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Fringe-like Chalcone PF02431.15 PIK39379.1 - 0.086 12.2 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Chalcone-flavanone isomerase Glyco_transf_10 PF00852.19 PIK39380.1 - 8.2e-44 149.4 0.5 1.3e-43 148.7 0.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK39380.1 - 1.9e-09 38.0 0.4 4.8e-09 36.7 0.4 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Col_cuticle_N PF01484.17 PIK39380.1 - 0.022 14.8 0.7 0.05 13.7 0.7 1.6 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain DAG1 PF05454.11 PIK39381.1 - 1.2e-06 28.2 0.1 3.8e-06 26.5 0.1 1.9 1 1 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Anoct_dimer PF16178.5 PIK39382.1 - 2e-19 70.3 0.7 1.8e-18 67.1 0.7 2.1 1 1 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Anoctamin PF04547.12 PIK39383.1 - 8.8e-50 169.8 0.1 1.2e-15 57.3 0.0 3.0 1 1 2 3 3 3 3 Calcium-activated chloride channel FA_desaturase PF00487.24 PIK39383.1 - 0.046 13.5 0.1 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Fatty acid desaturase Anoctamin PF04547.12 PIK39384.1 - 5e-18 65.2 0.7 6.2e-18 64.9 0.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel UCH PF00443.29 PIK39385.1 - 1.6e-14 54.0 1.3 3.6e-08 33.2 0.2 2.3 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK39385.1 - 0.0019 17.8 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ank_2 PF12796.7 PIK39386.1 - 5.1e-104 341.0 14.6 2.5e-16 60.0 0.2 8.5 3 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK39386.1 - 1.9e-76 251.5 6.9 6.8e-11 42.5 0.0 12.5 2 2 10 13 13 13 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK39386.1 - 1.9e-56 187.3 16.1 1.3e-08 34.9 0.1 11.7 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank PF00023.30 PIK39386.1 - 9e-56 184.0 19.1 1.4e-06 28.5 0.4 16.1 15 1 0 15 15 15 12 Ankyrin repeat Ank_3 PF13606.6 PIK39386.1 - 2e-47 153.6 3.9 0.00065 20.0 0.0 14.2 14 1 0 14 14 14 10 Ankyrin repeat AAA_16 PF13191.6 PIK39386.1 - 1e-07 32.5 0.0 1.1e-06 29.1 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 PIK39386.1 - 0.00024 21.1 0.2 0.0041 17.0 0.0 3.0 3 1 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 PIK39386.1 - 0.07 13.4 0.2 2.9 8.2 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 PIK39386.1 - 0.11 12.9 0.1 0.51 10.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 PIK39386.1 - 0.11 11.9 0.0 2.5 7.5 0.0 2.9 3 1 0 3 3 3 0 Bacterial TniB protein AAA PF00004.29 PIK39386.1 - 0.14 12.6 0.0 2.9 8.3 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NUC130_3NT PF08158.12 PIK39386.1 - 0.16 12.3 0.1 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 NUC130/3NT domain ALS_ss_C PF10369.9 PIK39386.1 - 0.17 12.1 0.0 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Small subunit of acetolactate synthase Ank_4 PF13637.6 PIK39387.1 - 1.2e-22 79.9 1.6 4.7e-12 46.2 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK39387.1 - 1.2e-18 67.4 2.1 3.9e-15 56.2 0.8 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK39387.1 - 1.1e-14 54.1 1.6 4.1e-05 23.8 0.1 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK39387.1 - 6.5e-13 48.6 4.5 8.6e-08 32.3 0.8 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK39387.1 - 9.8e-09 34.8 0.2 0.016 15.7 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Phage_min_cap2 PF06152.11 PIK39387.1 - 0.086 11.7 0.2 0.099 11.5 0.2 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 Env-gp36 PF09590.10 PIK39387.1 - 0.23 9.8 0.0 0.26 9.6 0.0 1.0 1 0 0 1 1 1 0 Lentivirus surface glycoprotein Steroid_dh PF02544.16 PIK39388.1 - 1.5e-25 89.9 4.4 2.7e-25 89.1 3.9 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase MFS_1_like PF12832.7 PIK39389.1 - 7.5e-71 239.0 19.1 4.7e-64 216.6 9.5 2.1 1 1 1 2 2 2 2 MFS_1 like family Nuc_H_symport PF03825.16 PIK39389.1 - 3e-14 52.8 8.9 3e-14 52.8 8.9 1.9 1 1 1 2 2 2 1 Nucleoside H+ symporter MFS_1 PF07690.16 PIK39389.1 - 3.4e-14 52.5 32.9 1.8e-08 33.7 20.4 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily LacY_symp PF01306.19 PIK39389.1 - 0.002 16.9 16.7 0.13 11.0 9.1 2.9 1 1 1 2 2 2 2 LacY proton/sugar symporter MFS_3 PF05977.13 PIK39389.1 - 0.0028 16.1 0.9 0.0044 15.5 0.9 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector NOA36 PF06524.12 PIK39390.1 - 1.1e-08 34.8 22.0 1.3e-08 34.6 22.0 1.0 1 0 0 1 1 1 1 NOA36 protein CDC45 PF02724.14 PIK39390.1 - 0.091 11.0 8.4 0.098 10.9 8.4 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 PIK39390.1 - 0.57 10.6 24.9 1.2 9.6 19.4 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SDA1 PF05285.12 PIK39390.1 - 0.66 9.3 13.7 0.81 9.1 13.7 1.1 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 PIK39390.1 - 0.93 8.0 11.2 1.1 7.8 11.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 PIK39390.1 - 1.3 8.3 14.3 1.6 8.0 14.3 1.0 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 PIK39390.1 - 2.3 7.9 9.8 1.2 8.8 6.1 2.0 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 PIK39390.1 - 2.7 6.1 16.9 3 6.0 16.9 1.0 1 0 0 1 1 1 0 Nop14-like family Rad21_Rec8_N PF04825.13 PIK39392.1 - 5.2e-39 132.8 0.0 1.1e-38 131.8 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein SPOC PF07744.13 PIK39393.1 - 9.5e-23 80.8 0.0 1.5e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 SPOC domain Tau95 PF09734.9 PIK39393.1 - 0.2 12.5 2.9 15 6.4 0.3 2.9 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TFIIS_M PF07500.14 PIK39394.1 - 4.4e-30 104.4 3.1 4.4e-30 104.4 3.1 2.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 PIK39394.1 - 2.3e-11 43.4 14.7 2.3e-11 43.4 14.7 1.9 2 0 0 2 2 2 1 PHD-finger BRK PF07533.16 PIK39394.1 - 5.3e-11 42.0 0.3 1e-10 41.0 0.3 1.5 1 0 0 1 1 1 1 BRK domain PHD_4 PF16866.5 PIK39394.1 - 0.025 14.7 11.5 0.077 13.1 11.5 1.9 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 PIK39394.1 - 0.13 12.5 4.1 0.49 10.7 4.1 2.0 1 0 0 1 1 1 0 PHD-like zinc-binding domain Mu-like_Pro PF10123.9 PIK39394.1 - 0.15 11.6 6.7 0.21 11.1 5.4 1.9 1 1 1 2 2 2 0 Mu-like prophage I protein zf-4CXXC_R1 PF10497.9 PIK39394.1 - 2 8.7 13.1 0.68 10.2 8.3 2.3 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_2 PF13639.6 PIK39394.1 - 2.9 8.3 11.8 6.9 7.1 11.8 1.6 1 0 0 1 1 1 0 Ring finger domain PI31_Prot_N PF11566.8 PIK39396.1 - 8.5e-14 51.7 0.0 1.3e-13 51.0 0.0 1.3 1 1 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 PIK39396.1 - 0.00044 21.4 5.8 0.005 18.0 5.7 2.6 1 1 0 1 1 1 1 PI31 proteasome regulator MIP PF00230.20 PIK39397.1 - 4.2e-39 134.6 6.7 5.4e-39 134.2 6.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein RDD PF06271.12 PIK39398.1 - 0.034 14.3 5.6 0.32 11.2 5.6 2.5 1 1 0 1 1 1 0 RDD family UPF0020 PF01170.18 PIK39399.1 - 3.4e-12 46.5 0.0 1.2e-11 44.7 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 PIK39399.1 - 1.7e-06 27.9 0.5 0.0025 17.6 0.0 2.4 2 1 0 2 2 2 2 DNA methylase N6_Mtase PF02384.16 PIK39399.1 - 1.2e-05 24.7 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 PIK39399.1 - 0.00047 19.9 1.0 0.34 10.6 0.2 2.8 3 0 0 3 3 3 2 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_11 PF08241.12 PIK39399.1 - 0.0014 19.2 0.0 0.0044 17.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK39399.1 - 0.1 12.3 0.2 0.34 10.5 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical protein 95 N6-adenineMlase PF10237.9 PIK39399.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase TPR_19 PF14559.6 PIK39400.1 - 2.4e-13 50.4 0.3 1.8e-05 25.2 0.0 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39400.1 - 4.5e-10 38.8 12.9 3.5e-06 26.7 0.4 4.6 5 1 0 5 5 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39400.1 - 6.5e-10 39.0 0.4 0.0063 17.2 0.2 4.5 1 1 4 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39400.1 - 8.3e-10 38.1 12.7 0.00032 20.7 0.2 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK39400.1 - 4.3e-08 33.7 0.2 0.032 14.9 0.0 3.9 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39400.1 - 2e-07 30.5 5.1 0.0011 18.7 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK39400.1 - 4e-07 30.2 0.8 0.074 13.7 0.1 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK39400.1 - 0.00033 20.8 0.1 0.0068 16.5 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK39400.1 - 0.00037 20.7 4.8 3.5 8.2 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39400.1 - 0.00097 19.0 1.3 0.26 11.4 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 PIK39400.1 - 0.0015 19.0 0.3 0.0044 17.5 0.1 1.9 2 1 0 2 2 2 1 Alkyl sulfatase dimerisation NARP1 PF12569.8 PIK39400.1 - 0.0045 16.0 4.5 0.0082 15.1 2.9 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 PIK39400.1 - 0.0046 16.2 0.1 0.0061 15.8 0.1 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK39400.1 - 0.046 14.0 5.7 0.095 12.9 1.1 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Merozoite_SPAM PF07133.11 PIK39400.1 - 0.076 13.0 0.4 0.34 10.9 0.0 2.1 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) TPR_20 PF14561.6 PIK39400.1 - 0.091 13.1 0.6 0.92 9.9 0.0 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39400.1 - 0.095 13.0 4.1 4.7 7.6 0.0 3.4 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39400.1 - 8.7 6.1 9.0 4.5 7.0 0.1 3.7 4 0 0 4 4 4 0 TPR repeat Ax_dynein_light PF10211.9 PIK39401.1 - 1.9e-95 318.2 13.4 2.3e-95 317.9 13.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain RIB43A PF05914.12 PIK39401.1 - 0.00079 18.3 8.7 0.00079 18.3 8.7 1.5 2 0 0 2 2 2 1 RIB43A Syntaxin-6_N PF09177.11 PIK39401.1 - 0.0015 19.0 6.2 0.0034 17.9 6.2 1.6 1 0 0 1 1 1 1 Syntaxin 6, N-terminal ADIP PF11559.8 PIK39401.1 - 0.018 15.1 10.2 0.044 13.9 10.2 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HALZ PF02183.18 PIK39401.1 - 0.021 15.1 4.7 0.15 12.3 1.4 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF3958 PF13125.6 PIK39401.1 - 0.026 14.7 3.4 0.026 14.7 3.4 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF3958) DUF5082 PF16888.5 PIK39401.1 - 0.026 14.8 4.9 0.056 13.7 4.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF737 PF05300.11 PIK39401.1 - 0.048 14.0 7.7 0.098 13.0 7.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF737) EMP24_GP25L PF01105.24 PIK39401.1 - 0.13 12.2 1.8 0.19 11.7 1.8 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Jnk-SapK_ap_N PF09744.9 PIK39401.1 - 0.15 12.3 17.9 0.078 13.2 12.1 2.5 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Mto2_bdg PF12808.7 PIK39401.1 - 0.19 12.1 15.7 0.31 11.4 2.7 3.0 3 0 0 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region UPF0242 PF06785.11 PIK39401.1 - 0.23 11.6 11.3 0.023 14.8 6.5 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 PIK39401.1 - 0.27 12.3 8.4 3.5 8.7 1.9 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5320) FapA PF03961.13 PIK39401.1 - 0.28 9.7 6.2 0.38 9.3 6.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 PIK39401.1 - 0.3 11.5 5.9 2.2 8.7 1.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) End3 PF12761.7 PIK39401.1 - 0.39 10.9 9.0 0.092 12.9 5.1 1.8 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 FAM76 PF16046.5 PIK39401.1 - 0.39 10.0 8.0 0.7 9.2 8.0 1.4 1 0 0 1 1 1 0 FAM76 protein Spc24 PF08286.11 PIK39401.1 - 0.4 10.9 10.8 0.67 10.2 9.0 2.3 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 PRKG1_interact PF15898.5 PIK39401.1 - 0.5 11.3 12.5 0.32 11.9 9.6 2.1 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4482 PF14818.6 PIK39401.1 - 0.51 11.2 11.7 0.35 11.7 9.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) DUF724 PF05266.14 PIK39401.1 - 0.81 9.5 12.1 0.99 9.2 10.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TSNAXIP1_N PF15739.5 PIK39401.1 - 1.3 9.4 14.1 5.9 7.3 3.5 2.5 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus APG6_N PF17675.1 PIK39401.1 - 2.1 8.9 22.4 0.33 11.5 17.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Phage_lysis PF03245.13 PIK39401.1 - 3.2 7.9 8.9 0.65 10.1 5.2 1.7 2 0 0 2 2 1 0 Bacteriophage Rz lysis protein GrpE PF01025.19 PIK39401.1 - 3.8 7.1 11.1 11 5.7 11.1 1.8 1 0 0 1 1 1 0 GrpE BST2 PF16716.5 PIK39401.1 - 5.4 7.7 17.2 0.13 12.9 1.7 3.2 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 RRM_1 PF00076.22 PIK39402.1 - 3.7e-80 263.7 3.4 1.8e-20 72.5 0.3 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 PIK39402.1 - 6.8e-26 90.2 1.7 3.7e-25 87.9 1.6 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 PIK39402.1 - 5.3e-08 32.5 0.1 0.017 14.7 0.0 4.3 2 2 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK39402.1 - 6.8e-06 26.0 0.8 4.5 7.4 0.0 4.2 4 0 0 4 4 4 3 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 PIK39402.1 - 7.5e-06 26.0 1.3 2 8.6 0.0 4.9 4 3 0 4 4 4 2 RNA recognition motif Limkain-b1 PF11608.8 PIK39402.1 - 6.4e-05 23.0 1.9 2 8.5 0.1 4.4 4 0 0 4 4 4 1 Limkain b1 SET_assoc PF11767.8 PIK39402.1 - 0.0075 15.9 0.1 49 3.7 0.0 4.2 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated OB_RNB PF08206.11 PIK39402.1 - 0.0082 15.8 1.4 3 7.6 0.0 3.3 3 0 0 3 3 3 1 Ribonuclease B OB domain RRM_3 PF08777.11 PIK39402.1 - 0.013 15.5 1.6 5.8 7.0 0.1 3.5 4 0 0 4 4 4 0 RNA binding motif REC114-like PF15165.6 PIK39403.1 - 8.6e-16 58.4 1.1 3.4e-15 56.5 1.3 1.6 1 1 1 2 2 2 1 Meiotic recombination protein REC114-like NiFe_hyd_SSU_C PF14720.6 PIK39403.1 - 0.12 12.8 0.4 23 5.5 0.1 2.4 2 0 0 2 2 2 0 NiFe/NiFeSe hydrogenase small subunit C-terminal PABP PF00658.18 PIK39404.1 - 1.2e-54 182.3 10.4 4.9e-27 93.9 1.4 2.4 2 0 0 2 2 2 2 Poly-adenylate binding protein, unique domain RRM_1 PF00076.22 PIK39404.1 - 1e-06 28.4 0.1 2.3e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amj PF10997.8 PIK39404.1 - 0.0072 15.7 0.3 2.3 7.5 0.0 2.3 2 0 0 2 2 2 2 Alternate to MurJ YflT PF11181.8 PIK39404.1 - 0.032 14.7 0.0 2 9.0 0.0 3.0 3 0 0 3 3 3 0 Heat induced stress protein YflT NIL PF09383.10 PIK39404.1 - 0.11 12.4 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 NIL domain HTH_9 PF08221.11 PIK39404.1 - 0.22 11.6 0.5 17 5.6 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF3223 PF11523.8 PIK39404.1 - 0.32 11.9 1.8 14 6.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3223) GPS PF01825.21 PIK39405.1 - 2.5e-16 59.9 4.9 5.9e-16 58.7 4.9 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Aconitase_2_N PF06434.13 PIK39405.1 - 0.011 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Aconitate hydratase 2 N-terminus 7tm_2 PF00002.24 PIK39405.1 - 0.06 12.6 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) TMP_2 PF06791.13 PIK39405.1 - 0.063 12.9 0.5 0.1 12.2 0.5 1.3 1 0 0 1 1 1 0 Prophage tail length tape measure protein IgGFc_binding PF17517.2 PIK39406.1 - 6.8e-29 101.1 2.1 1.9e-27 96.3 0.1 2.1 1 1 1 2 2 2 2 IgGFc binding protein Ldl_recept_a PF00057.18 PIK39406.1 - 2.6e-09 37.1 10.4 4.1e-09 36.5 10.4 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Neuralized PF07177.12 PIK39407.1 - 4.6e-99 328.5 2.4 2.4e-40 138.0 0.5 3.2 3 0 0 3 3 3 3 Neuralized SDH_sah PF01972.16 PIK39407.1 - 0.12 11.3 0.2 11 4.9 0.0 2.9 3 0 0 3 3 3 0 Serine dehydrogenase proteinase Neuralized PF07177.12 PIK39408.1 - 2.4e-106 352.2 0.0 3.3e-41 140.8 0.0 3.3 3 0 0 3 3 3 3 Neuralized SPRY PF00622.28 PIK39408.1 - 6e-08 32.8 0.2 0.15 12.2 0.0 3.5 3 0 0 3 3 3 3 SPRY domain TPR_2 PF07719.17 PIK39409.1 - 9.2e-09 34.8 1.0 0.2 11.8 0.0 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39409.1 - 1.4e-07 31.0 5.1 0.0031 17.3 0.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-MYND PF01753.18 PIK39409.1 - 0.00052 20.0 12.3 0.00052 20.0 12.3 2.6 2 0 0 2 2 2 1 MYND finger TPR_7 PF13176.6 PIK39409.1 - 0.014 15.3 1.2 16 5.8 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Repressor_Mnt PF11423.8 PIK39409.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 Regulatory protein Mnt TPR_17 PF13431.6 PIK39409.1 - 0.4 11.2 3.1 4.2 8.0 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39409.1 - 0.87 10.0 4.3 11 6.5 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Elong_Iki1 PF10483.9 PIK39410.1 - 6.1e-19 68.6 2.3 6.7e-09 35.7 0.2 2.4 1 1 1 2 2 2 2 Elongator subunit Iki1 DUF3959 PF13105.6 PIK39410.1 - 0.052 13.0 0.1 0.096 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) NIF PF03031.18 PIK39411.1 - 5.9e-23 81.4 0.0 7.8e-23 81.0 0.0 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hyaluronidase_1 PF07212.11 PIK39411.1 - 0.15 11.3 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Hyaluronidase protein (HylP) Mab-21 PF03281.14 PIK39412.1 - 1.4e-39 136.2 0.0 1.7e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein RNA_pol PF00940.19 PIK39413.1 - 4.3e-162 539.7 0.0 8.6e-162 538.7 0.0 1.5 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 PIK39413.1 - 1.1e-46 159.8 0.9 2.1e-46 158.9 0.9 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 PIK39413.1 - 1.1e-05 25.5 0.0 0.00013 22.1 0.0 2.6 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 PIK39413.1 - 0.00019 21.5 0.2 0.074 13.1 0.0 3.8 3 1 1 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 PIK39413.1 - 0.0038 17.4 0.2 0.43 10.9 0.0 3.0 2 0 0 2 2 2 1 PPR repeat HEAT_UF PF18817.1 PIK39413.1 - 0.15 12.4 0.5 26 5.2 0.1 2.8 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 Solute_trans_a PF03619.16 PIK39414.1 - 1.1e-25 90.6 16.7 7.2e-24 84.7 16.7 2.1 1 1 0 1 1 1 1 Organic solute transporter Ostalpha DPM2 PF07297.12 PIK39414.1 - 4.2 7.7 10.5 17 5.8 0.3 4.3 5 0 0 5 5 5 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Ctf8 PF09696.10 PIK39414.1 - 6.1 7.2 11.6 10 6.4 1.6 2.3 1 1 1 2 2 2 0 Ctf8 Helicase_C PF00271.31 PIK39415.1 - 9.3e-18 64.6 0.0 2e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain rve PF00665.26 PIK39416.1 - 1.1e-22 80.4 0.0 1.6e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK39416.1 - 4.2e-07 30.0 1.0 7e-07 29.3 1.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK39416.1 - 3.5e-05 23.5 0.0 7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK39416.1 - 3.9e-05 23.4 0.0 6.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS240 PF13610.6 PIK39416.1 - 0.045 14.0 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 DDE domain RT_RNaseH_2 PF17919.1 PIK39417.1 - 1e-36 125.0 0.0 2.2e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK39417.1 - 1.2e-30 105.8 0.0 2.6e-30 104.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39417.1 - 1.1e-21 77.4 0.0 2.9e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK39417.1 - 0.0031 17.8 0.0 0.0073 16.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK39417.1 - 0.016 15.7 0.3 0.055 14.0 0.0 2.0 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK39417.1 - 0.028 15.0 0.1 0.068 13.8 0.0 1.7 2 0 0 2 2 2 0 Aspartyl protease DNA_pol_viral_C PF00336.18 PIK39417.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Retrotrans_gag PF03732.17 PIK39418.1 - 1.7e-05 25.0 0.0 8.6e-05 22.7 0.0 2.0 1 1 1 2 2 2 1 Retrotransposon gag protein RNase_T PF00929.24 PIK39418.1 - 0.011 16.3 0.0 0.015 15.8 0.0 1.3 1 0 0 1 1 1 0 Exonuclease Methyltransf_FA PF12248.8 PIK39419.1 - 3.6e-16 59.3 0.1 4.4e-13 49.4 0.0 2.5 2 0 0 2 2 2 2 Farnesoic acid 0-methyl transferase Urocanase_N PF17391.2 PIK39420.1 - 0.038 13.7 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Urocanase N-terminal domain PDEase_I PF00233.19 PIK39421.1 - 6.8e-80 268.2 1.9 9.9e-80 267.7 1.9 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Methyltransf_FA PF12248.8 PIK39422.1 - 6.8e-33 113.0 0.4 1.5e-16 60.6 0.0 2.3 2 0 0 2 2 2 2 Farnesoic acid 0-methyl transferase Gal_Lectin PF02140.18 PIK39422.1 - 1.3e-16 60.8 0.4 3e-16 59.6 0.4 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain EamA PF00892.20 PIK39423.1 - 4.3e-10 39.9 26.9 7.9e-07 29.3 7.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family NOB1_Zn_bind PF08772.11 PIK39423.1 - 0.14 12.3 0.5 0.3 11.3 0.5 1.6 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like rve PF00665.26 PIK39424.1 - 1.8e-18 66.9 0.0 2.6e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK39424.1 - 0.0018 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK39425.1 - 1e-22 80.8 0.0 1.2e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 PIK39426.1 - 2.3e-05 23.5 9.5 0.0024 16.9 9.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39426.1 - 0.00015 20.8 7.2 0.018 14.0 7.1 2.9 1 1 1 3 3 3 2 Sugar (and other) transporter CemA PF03040.14 PIK39427.1 - 0.2 11.6 3.6 0.26 11.2 3.6 1.1 1 0 0 1 1 1 0 CemA family HMG_box PF00505.19 PIK39428.1 - 3.8e-27 94.5 66.5 1.7e-12 47.6 7.7 7.2 6 2 0 6 6 6 5 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK39428.1 - 7.8e-11 42.4 60.4 0.0028 18.2 1.5 7.5 7 0 0 7 7 7 5 HMG-box domain HMG_box_5 PF14887.6 PIK39428.1 - 2.7e-05 24.0 3.1 2.7e-05 24.0 3.1 5.4 4 1 1 5 5 5 2 HMG (high mobility group) box 5 NOA36 PF06524.12 PIK39428.1 - 0.0013 18.1 32.2 0.016 14.5 9.9 2.4 2 0 0 2 2 2 2 NOA36 protein CENP-B_dimeris PF09026.10 PIK39428.1 - 3.2 8.2 45.5 0.029 14.7 13.6 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain TFIIA PF03153.13 PIK39428.1 - 6.5 6.6 51.3 0.5 10.3 18.7 2.8 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PI3_PI4_kinase PF00454.27 PIK39429.1 - 6.8e-34 117.8 0.2 2.2e-22 80.1 0.1 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 PIK39429.1 - 0.0021 17.5 0.0 0.0065 15.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4805 PF16063.5 PIK39429.1 - 0.09 12.1 2.4 0.19 11.1 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) Clathrin PF00637.20 PIK39430.1 - 2.3e-22 79.4 13.6 2.8e-15 56.4 2.7 2.8 2 0 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.8 PIK39430.1 - 9.8e-18 64.1 0.9 2.8e-17 62.7 0.9 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.6 PIK39430.1 - 1.3e-06 28.2 9.1 1.3e-06 28.2 9.1 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK39430.1 - 7e-05 23.1 8.4 7e-05 23.1 8.4 3.3 2 1 1 3 3 2 1 Ring finger domain A2L_zn_ribbon PF08792.10 PIK39430.1 - 0.00087 18.9 3.6 18 5.2 0.0 4.4 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-C3H2C3 PF17122.5 PIK39430.1 - 0.0012 18.8 11.1 0.0012 18.8 11.1 4.5 4 0 0 4 4 4 1 Zinc-finger zf-RING_5 PF14634.6 PIK39430.1 - 0.0044 17.0 8.1 0.0044 17.0 8.1 3.5 2 1 2 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK39430.1 - 0.011 15.6 8.3 0.011 15.6 8.3 2.5 4 0 0 4 4 3 0 Zinc finger, C3HC4 type (RING finger) TPR_11 PF13414.6 PIK39430.1 - 0.077 12.7 0.0 0.25 11.1 0.0 1.9 1 0 0 1 1 1 0 TPR repeat Vps8 PF12816.7 PIK39430.1 - 0.086 12.3 3.3 1.7 8.1 0.1 2.8 2 1 0 2 2 2 0 Golgi CORVET complex core vacuolar protein 8 zf-rbx1 PF12678.7 PIK39430.1 - 0.34 11.2 18.4 0.33 11.3 12.7 3.2 1 1 2 3 3 3 0 RING-H2 zinc finger domain CSTF2_hinge PF14327.6 PIK39430.1 - 0.71 10.4 2.4 0.8 10.2 0.6 2.1 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 zinc_ribbon_12 PF11331.8 PIK39430.1 - 0.97 9.3 12.0 6.5 6.6 2.2 3.5 1 1 3 4 4 4 0 Probable zinc-ribbon domain C1_1 PF00130.22 PIK39430.1 - 4 7.4 19.1 3.8 7.5 1.1 3.5 1 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_S14 PF00253.21 PIK39431.1 - 1.7e-18 66.1 0.2 1.7e-18 66.1 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e PSS PF03034.15 PIK39432.1 - 4.2e-26 92.3 4.8 4.2e-26 92.3 4.8 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase Cation_efflux PF01545.21 PIK39432.1 - 0.0028 17.4 0.6 0.65 9.7 0.4 2.1 2 0 0 2 2 2 2 Cation efflux family OAD_gamma PF04277.13 PIK39432.1 - 0.037 14.6 0.1 0.63 10.7 0.0 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain EGF_2 PF07974.13 PIK39433.1 - 0.00072 19.9 8.6 0.0016 18.7 8.6 1.6 1 0 0 1 1 1 1 EGF-like domain cEGF PF12662.7 PIK39433.1 - 0.0061 16.5 2.5 0.48 10.4 0.0 2.7 2 0 0 2 2 2 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK39433.1 - 1.5 9.1 12.3 2.7 8.3 0.0 3.1 3 0 0 3 3 3 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK39434.1 - 0.0017 18.2 4.4 0.0052 16.7 4.4 1.8 1 0 0 1 1 1 1 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK39434.1 - 0.0034 17.5 0.2 0.0085 16.3 0.2 1.8 1 1 0 1 1 1 1 EGF domain Drf_FH1 PF06346.12 PIK39434.1 - 0.71 9.6 17.4 0.72 9.6 13.3 2.3 3 0 0 3 3 3 0 Formin Homology Region 1 UPF0560 PF10577.9 PIK39435.1 - 5.4e-10 38.5 0.0 6.7e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 Sushi PF00084.20 PIK39435.1 - 0.0043 17.6 0.7 0.013 16.0 0.7 2.0 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) 7tm_1 PF00001.21 PIK39436.1 - 8.1e-25 87.6 14.8 1.2e-24 87.0 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK39436.1 - 6.1e-17 61.1 13.0 5.6e-14 51.6 3.5 3.5 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK39436.1 - 2e-09 37.6 18.9 6.2e-07 29.6 0.8 5.2 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK39436.1 - 1.9e-05 24.6 1.7 0.1 12.6 0.0 2.6 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) 7TM_GPCR_Srx PF10328.9 PIK39436.1 - 8.3e-05 22.3 17.6 0.00014 21.6 17.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx LRR_9 PF14580.6 PIK39436.1 - 0.00013 21.5 2.6 0.00031 20.3 0.6 2.6 3 1 1 4 4 4 1 Leucine-rich repeat LRRNT PF01462.18 PIK39436.1 - 0.012 15.2 3.8 0.012 15.2 3.8 2.0 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Srg PF02118.21 PIK39436.1 - 0.87 9.2 18.4 2.1 7.9 18.4 1.7 1 1 0 1 1 1 0 Srg family chemoreceptor FERM_M PF00373.18 PIK39437.1 - 7.6e-12 45.7 1.0 1.8e-11 44.5 1.0 1.6 1 0 0 1 1 1 1 FERM central domain WW PF00397.26 PIK39437.1 - 2.9e-11 43.2 0.7 1e-05 25.5 0.0 2.7 2 0 0 2 2 2 2 WW domain PDZ PF00595.24 PIK39437.1 - 3.9e-07 30.3 0.0 1.1e-06 28.9 0.0 1.8 1 0 0 1 1 1 1 PDZ domain FERM_N PF09379.10 PIK39437.1 - 1.7e-05 24.6 0.1 5.5e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 FERM N-terminal domain PDZ_2 PF13180.6 PIK39437.1 - 7.2e-05 23.0 0.1 0.0005 20.3 0.1 2.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK39437.1 - 0.0064 16.3 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Sec5 PF15469.6 PIK39438.1 - 0.014 15.3 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec5 LemA PF04011.12 PIK39438.1 - 0.047 13.5 0.1 0.055 13.3 0.1 1.1 1 0 0 1 1 1 0 LemA family PDZ PF00595.24 PIK39439.1 - 8.7e-17 61.3 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK39439.1 - 1.3e-11 44.2 0.0 1.7e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK39439.1 - 0.00018 21.8 0.0 0.00021 21.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain FH2 PF02181.23 PIK39440.1 - 8.9e-92 308.1 11.1 1.2e-91 307.6 11.1 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain HTH_48 PF17906.1 PIK39440.1 - 0.028 14.5 0.3 0.085 13.0 0.0 2.0 2 0 0 2 2 2 0 HTH domain in Mos1 transposase HMGL-like PF00682.19 PIK39440.1 - 0.059 12.9 0.4 0.13 11.8 0.3 1.6 2 0 0 2 2 2 0 HMGL-like DNA_pack_N PF02500.15 PIK39440.1 - 0.13 12.1 2.8 2.8 7.7 0.3 2.4 1 1 1 2 2 2 0 Probable DNA packing protein, N-terminus RNA_POL_M_15KD PF02150.16 PIK39441.1 - 6.4e-15 54.7 6.0 6.4e-15 54.7 6.0 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 PIK39441.1 - 5.4e-13 48.6 15.6 7.4e-13 48.1 6.2 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.6 PIK39441.1 - 0.034 14.7 0.1 0.034 14.7 0.1 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Arc_trans_TRASH PF08394.10 PIK39441.1 - 0.042 14.2 2.1 0.042 14.2 2.1 3.1 4 0 0 4 4 4 0 Archaeal TRASH domain Ogr_Delta PF04606.12 PIK39441.1 - 0.049 13.6 6.8 0.049 13.6 6.8 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DUF3716 PF12511.8 PIK39441.1 - 0.062 13.4 8.7 0.58 10.2 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) zinc_ribbon_9 PF14369.6 PIK39441.1 - 0.078 13.2 5.8 3.4 8.0 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon Ribosomal_S27e PF01667.17 PIK39441.1 - 1.8 8.3 6.9 1.8 8.3 0.3 2.9 3 0 0 3 3 3 0 Ribosomal protein S27 CpXC PF14353.6 PIK39441.1 - 6.6 6.8 10.1 4.8 7.3 0.5 2.4 1 1 0 2 2 2 0 CpXC protein DUF2052 PF09747.9 PIK39442.1 - 7.8e-52 176.3 29.9 7.8e-52 176.3 29.9 1.9 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) Rhabdo_ncap PF00945.18 PIK39442.1 - 0.018 13.9 0.6 0.044 12.7 0.6 1.6 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Peptidase_C97 PF05903.14 PIK39443.1 - 1.7e-38 131.8 0.0 2e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 PIK39443.1 - 0.065 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase MAJIN PF15077.6 PIK39444.1 - 1.5e-07 31.5 0.3 1.5e-07 31.5 0.3 2.4 1 1 1 2 2 2 1 Membrane-anchored junction protein Peptidase_A17 PF05380.13 PIK39445.1 - 1.3e-25 90.3 0.1 4.5e-25 88.6 0.0 1.9 2 0 0 2 2 2 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK39445.1 - 0.00053 19.9 0.0 0.0019 18.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 PIK39445.1 - 0.005 16.6 0.2 0.013 15.3 0.2 1.7 1 0 0 1 1 1 1 Putative peptidase (DUF1758) RVT_1 PF00078.27 PIK39445.1 - 0.046 13.2 0.0 0.3 10.6 0.0 2.1 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 PIK39445.1 - 0.054 13.3 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK39445.1 - 0.18 12.5 0.0 0.42 11.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease adh_short PF00106.25 PIK39446.1 - 4.1e-26 91.6 0.5 2.2e-24 86.0 0.5 2.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39446.1 - 1.3e-14 54.4 0.0 7.5e-14 51.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39446.1 - 1.1e-08 35.2 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Pyr_redox_3 PF13738.6 PIK39446.1 - 0.029 13.6 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 PIK39446.1 - 0.096 12.9 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 PIK39446.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.21 PIK39446.1 - 0.33 11.0 2.0 1.5 8.9 2.1 1.8 1 1 1 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Meckelin PF09773.9 PIK39447.1 - 1.9e-184 615.1 28.4 2e-65 221.4 3.2 4.5 3 1 2 5 5 5 4 Meckelin (Transmembrane protein 67) DUF86 PF01934.17 PIK39447.1 - 0.19 11.6 0.0 3.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF86 Anti-TRAP PF15777.5 PIK39447.1 - 0.84 9.6 6.0 61 3.7 0.0 3.1 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-C2H2 PF00096.26 PIK39448.1 - 1e-26 91.9 35.3 1.4e-07 31.6 0.9 5.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK39448.1 - 3.9e-25 87.1 34.5 2.6e-09 37.1 0.3 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK39448.1 - 1.4e-19 69.1 32.6 2.7e-05 24.6 0.7 5.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39448.1 - 4.4e-10 39.6 20.7 9.3e-05 22.6 0.2 5.0 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK39448.1 - 1.4e-09 38.1 22.1 0.00021 21.5 4.6 4.1 1 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK39448.1 - 1.2e-08 34.7 33.5 0.00019 21.3 0.7 5.6 5 1 0 5 5 5 4 C2H2-type zinc finger zf-BED PF02892.15 PIK39448.1 - 2.4e-07 30.6 23.8 9.6e-05 22.3 1.9 4.9 3 2 2 5 5 5 2 BED zinc finger zf-met PF12874.7 PIK39448.1 - 7.3e-07 29.4 24.3 0.00051 20.3 0.7 4.9 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK39448.1 - 3.6e-06 27.2 22.9 0.74 10.2 4.1 4.6 1 1 3 4 4 4 4 C2H2 type zinc-finger (2 copies) FYDLN_acid PF09538.10 PIK39448.1 - 3e-05 24.7 9.3 0.28 11.9 0.8 4.1 1 1 2 3 3 3 1 Protein of unknown function (FYDLN_acid) zf-C2HE PF16278.5 PIK39448.1 - 3.9e-05 24.0 28.4 0.0011 19.3 2.4 5.1 1 1 3 4 4 4 1 C2HE / C2H2 / C2HC zinc-binding finger Elf1 PF05129.13 PIK39448.1 - 0.00013 21.9 2.7 0.00013 21.9 2.7 2.8 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like zf-H2C2_5 PF13909.6 PIK39448.1 - 0.00019 21.1 32.7 0.16 11.7 1.2 5.7 5 0 0 5 5 5 3 C2H2-type zinc-finger domain CpXC PF14353.6 PIK39448.1 - 0.00027 21.0 7.9 0.41 10.7 0.2 3.4 2 1 1 3 3 3 1 CpXC protein zinc_ribbon_9 PF14369.6 PIK39448.1 - 0.00037 20.7 7.9 1.7 8.9 0.0 4.3 4 0 0 4 4 4 1 zinc-ribbon TRAF6_Z2 PF18048.1 PIK39448.1 - 0.00038 20.5 16.0 0.074 13.2 0.2 4.1 4 0 0 4 4 3 2 TNF receptor-associated factor 6 zinc finger 2 zf-C2HC_2 PF13913.6 PIK39448.1 - 0.00047 20.0 15.2 0.99 9.4 0.6 4.4 4 0 0 4 4 4 1 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 PIK39448.1 - 0.001 19.1 14.7 0.065 13.4 1.6 3.7 3 1 0 3 3 3 1 Zinc ribbon domain zf-C2H2_11 PF16622.5 PIK39448.1 - 0.002 17.8 15.3 0.63 9.9 0.1 4.5 5 0 0 5 5 4 1 zinc-finger C2H2-type zf_UBZ PF18439.1 PIK39448.1 - 0.0031 17.1 10.6 1 9.0 0.1 4.3 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger zf-C2H2_9 PF16293.5 PIK39448.1 - 0.0033 17.2 10.2 0.14 12.0 0.6 3.8 4 1 0 4 4 4 1 C2H2 type zinc-finger (1 copy) zf-C2H2_3rep PF18868.1 PIK39448.1 - 0.0045 17.7 12.4 0.097 13.3 1.7 2.9 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-CHCC PF10276.9 PIK39448.1 - 0.0057 16.7 8.8 0.21 11.6 0.1 4.1 4 0 0 4 4 4 1 Zinc-finger domain GAGA PF09237.11 PIK39448.1 - 0.0094 15.7 13.3 0.54 10.1 2.1 3.8 1 1 4 5 5 5 2 GAGA factor zf-AN1 PF01428.16 PIK39448.1 - 0.012 15.8 19.2 0.44 10.8 0.5 4.5 3 1 1 4 4 4 0 AN1-like Zinc finger zf-C2H2_8 PF15909.5 PIK39448.1 - 0.018 15.3 15.2 0.53 10.6 4.6 2.4 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-TRAF PF02176.18 PIK39448.1 - 0.02 15.5 3.5 0.02 15.5 3.5 3.4 1 1 2 3 3 3 0 TRAF-type zinc finger zf_C2H2_6 PF18450.1 PIK39448.1 - 0.021 14.5 1.3 3.5 7.4 0.4 2.7 2 0 0 2 2 2 0 Zinc Finger domain Zn-C2H2_12 PF18112.1 PIK39448.1 - 0.022 15.2 21.9 0.12 12.9 3.0 4.6 4 1 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain HypA PF01155.19 PIK39448.1 - 0.041 13.9 8.6 0.052 13.6 2.3 2.8 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HNH PF01844.23 PIK39448.1 - 0.051 13.7 10.7 2.4 8.4 0.2 4.1 4 0 0 4 4 4 0 HNH endonuclease HNH_5 PF14279.6 PIK39448.1 - 0.1 12.4 12.2 14 5.7 1.5 4.4 3 1 0 3 3 3 0 HNH endonuclease zinc_ribbon_15 PF17032.5 PIK39448.1 - 0.13 13.0 14.1 6.1 7.7 5.1 2.9 1 1 2 3 3 3 0 zinc-ribbon family PyrI_C PF02748.15 PIK39448.1 - 0.13 12.2 7.2 0.55 10.2 0.4 3.4 3 1 1 4 4 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2225 PF09986.9 PIK39448.1 - 0.15 11.8 14.7 0.74 9.5 0.5 3.9 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) Rad50_zn_hook PF04423.14 PIK39448.1 - 0.19 11.6 4.8 3.5 7.5 0.1 3.0 2 1 1 3 3 3 0 Rad50 zinc hook motif DUF2256 PF10013.9 PIK39448.1 - 0.21 11.7 14.5 4.5 7.5 0.7 4.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) YacG PF03884.14 PIK39448.1 - 0.24 11.2 8.8 9.6 6.0 0.2 3.4 2 1 0 2 2 2 0 DNA gyrase inhibitor YacG zf-ISL3 PF14690.6 PIK39448.1 - 0.24 12.1 13.6 8.4 7.2 0.5 4.1 4 0 0 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Rpr2 PF04032.16 PIK39448.1 - 0.29 11.4 14.1 1.4 9.2 2.0 2.8 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-RING_7 PF02591.15 PIK39448.1 - 0.3 11.3 2.8 5.2 7.4 0.1 3.1 3 0 0 3 3 2 0 C4-type zinc ribbon domain Cys_rich_CPXG PF14255.6 PIK39448.1 - 0.31 11.0 6.1 4.4 7.3 0.0 3.8 4 0 0 4 4 3 0 Cysteine-rich CPXCG FYVE PF01363.21 PIK39448.1 - 0.36 11.0 18.9 1.9 8.7 9.2 3.3 1 1 1 2 2 2 0 FYVE zinc finger YhfH PF14149.6 PIK39448.1 - 0.38 10.8 5.4 5.5 7.1 0.1 3.4 3 0 0 3 3 3 0 YhfH-like protein Ogr_Delta PF04606.12 PIK39448.1 - 0.4 10.7 7.1 0.43 10.6 2.2 2.6 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DUF629 PF04780.12 PIK39448.1 - 0.42 9.1 17.4 0.036 12.6 1.8 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-LYAR PF08790.11 PIK39448.1 - 0.5 10.3 18.8 7.6 6.5 1.0 5.2 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Baculo_IE-1 PF05290.11 PIK39448.1 - 0.52 10.3 0.1 0.52 10.3 0.1 2.9 2 1 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) DZR PF12773.7 PIK39448.1 - 0.55 10.3 17.1 1.8e+03 -1.0 17.1 3.3 1 1 0 1 1 1 0 Double zinc ribbon zf-TFIIB PF13453.6 PIK39448.1 - 1 8.7 5.8 2.9 7.3 0.1 2.9 2 1 0 2 2 2 0 Transcription factor zinc-finger zinc-ribbons_6 PF07191.12 PIK39448.1 - 1.2 9.2 12.8 1.2e+02 2.7 3.1 3.2 1 1 1 2 2 2 0 zinc-ribbons ADK_lid PF05191.14 PIK39448.1 - 1.3 9.0 11.7 2.3 8.3 1.8 2.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid C1_4 PF07975.12 PIK39448.1 - 1.5 9.1 14.6 2.8 8.2 0.9 3.4 1 1 3 4 4 4 0 TFIIH C1-like domain TF_Zn_Ribbon PF08271.12 PIK39448.1 - 1.9 8.1 13.4 0.5 9.9 1.5 3.5 2 2 0 2 2 2 0 TFIIB zinc-binding Zn_ribbon_recom PF13408.6 PIK39448.1 - 2 9.0 8.1 7.2 7.2 1.7 3.3 2 2 1 3 3 3 0 Recombinase zinc beta ribbon domain NADH-G_4Fe-4S_3 PF10588.9 PIK39448.1 - 2.2 7.9 11.0 4.4 6.9 0.2 4.0 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region LIM PF00412.22 PIK39448.1 - 2.5 8.4 15.9 8.6 6.7 3.2 3.7 2 1 1 3 3 3 0 LIM domain DUF4796 PF16044.5 PIK39448.1 - 2.8 7.5 10.4 0.8 9.3 1.6 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4796) DUF3797 PF12677.7 PIK39448.1 - 3.1 7.7 5.8 15 5.6 1.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) zf-trcl PF13451.6 PIK39448.1 - 4.5 7.2 16.1 13 5.8 0.2 4.1 4 0 0 4 4 4 0 Probable zinc-ribbon domain Mut7-C PF01927.16 PIK39448.1 - 5.8 7.0 8.9 2.1 8.5 1.7 2.8 1 1 2 3 3 3 0 Mut7-C RNAse domain zf-ribbon_3 PF13248.6 PIK39448.1 - 5.9 6.4 14.3 5.6 6.5 0.2 3.8 4 0 0 4 4 3 0 zinc-ribbon domain NOB1_Zn_bind PF08772.11 PIK39448.1 - 6.1 7.1 13.6 3.8 7.7 0.9 3.2 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like DUF4379 PF14311.6 PIK39448.1 - 7.8 7.0 12.7 9.4 6.7 0.4 3.6 2 1 0 3 3 3 0 Probable Zinc-ribbon domain DNA_ligase_ZBD PF03119.16 PIK39448.1 - 8.3 6.5 8.4 15 5.7 0.4 3.1 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Ribosomal_L37ae PF01780.19 PIK39448.1 - 8.7 6.5 13.4 30 4.8 0.1 4.0 3 1 0 3 3 3 0 Ribosomal L37ae protein family zf-H2C2_2 PF13465.6 PIK39450.1 - 1.2e-88 287.9 163.4 1e-09 38.4 1.0 22.4 22 0 0 22 22 22 18 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39450.1 - 2.4e-79 257.6 187.3 4.7e-07 29.9 3.5 21.4 21 0 0 21 21 21 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK39450.1 - 7.2e-57 185.1 175.6 0.00053 20.6 0.5 21.4 21 0 0 21 21 21 21 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39450.1 - 5.1e-29 99.9 127.4 0.00017 21.8 0.1 20.2 21 0 0 21 21 21 12 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK39450.1 - 1.7e-13 50.5 125.3 0.021 15.2 1.6 17.8 18 0 0 18 18 18 11 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK39450.1 - 3.4e-13 49.2 161.8 0.00065 19.6 0.1 21.5 21 1 0 21 21 21 12 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK39450.1 - 3.3e-07 29.9 6.7 0.0012 18.5 0.9 16.9 18 0 0 18 18 18 5 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 PIK39450.1 - 9.6e-07 29.0 95.9 0.0015 18.8 1.8 10.6 5 5 7 12 12 12 8 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 PIK39450.1 - 0.00093 19.9 80.5 0.75 10.6 0.7 11.7 7 3 10 17 17 17 6 zinc-ribbon family zf-C2HE PF16278.5 PIK39450.1 - 0.0066 16.9 0.5 0.0066 16.9 0.5 18.7 8 8 9 17 17 16 4 C2HE / C2H2 / C2HC zinc-binding finger DUF1864 PF08933.11 PIK39450.1 - 0.01 14.6 3.7 0.019 13.7 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) zf-H2C2_5 PF13909.6 PIK39450.1 - 0.015 15.1 0.3 0.015 15.1 0.3 18.9 22 2 0 22 22 20 0 C2H2-type zinc-finger domain VAPB_antitox PF02697.14 PIK39450.1 - 0.21 12.4 2.3 0.32 11.8 0.5 2.2 2 0 0 2 2 2 0 Putative antitoxin Sld5 PF05916.11 PIK39451.1 - 0.045 14.2 0.0 0.062 13.8 0.0 1.4 1 1 0 1 1 1 0 GINS complex protein DUF1279 PF06916.13 PIK39452.1 - 1.6e-11 44.6 0.1 2.8e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Pkinase PF00069.25 PIK39453.1 - 6.4e-42 143.7 0.1 1.4e-20 73.8 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39453.1 - 3.1e-25 88.9 0.1 1.2e-14 54.3 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase LIX1 PF14954.6 PIK39455.1 - 3.4e-137 455.6 0.5 4e-137 455.4 0.5 1.0 1 0 0 1 1 1 1 Limb expression 1 TF_AP-2 PF03299.14 PIK39455.1 - 0.061 13.3 0.1 1.3 8.9 0.0 2.3 2 1 0 2 2 2 0 Transcription factor AP-2 Dicer_dimer PF03368.14 PIK39455.1 - 0.071 13.3 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Dicer dimerisation domain SF3A2 PF16835.5 PIK39456.1 - 8.3e-28 96.6 0.0 1.4e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 PIK39456.1 - 4.2e-07 30.1 2.0 8.1e-07 29.2 2.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 PIK39456.1 - 0.13 11.9 3.2 0.21 11.2 3.2 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like DUF4781 PF16013.5 PIK39458.1 - 0.12 11.2 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Galactosyl_T PF01762.21 PIK39459.1 - 4.5e-47 160.4 0.0 6.8e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK39459.1 - 0.0024 17.3 0.0 0.0044 16.5 0.0 1.4 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 PIK39460.1 - 5.2e-41 140.6 0.0 6.9e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK39460.1 - 8e-06 25.5 0.1 1.8e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 Fringe-like DUF1647 PF07801.11 PIK39460.1 - 0.031 14.0 0.2 0.094 12.5 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1647) NACHT PF05729.12 PIK39461.1 - 1.7e-12 47.5 0.0 4.9e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 NACHT domain ATPase PF06745.13 PIK39461.1 - 0.00085 18.7 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 PIK39461.1 - 0.0017 18.0 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 PIK39461.1 - 0.17 11.6 0.0 0.43 10.3 0.0 1.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase Iso_dh PF00180.20 PIK39462.1 - 5e-69 233.1 0.0 5.6e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase START PF01852.19 PIK39463.1 - 2.9e-10 39.9 0.0 4e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 START domain Mitofilin PF09731.9 PIK39463.1 - 0.0027 16.6 10.6 0.0035 16.3 10.6 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein NPR3 PF03666.13 PIK39463.1 - 0.0037 16.1 5.2 0.0044 15.9 5.2 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.10 PIK39463.1 - 0.0039 16.6 15.6 0.0045 16.4 15.6 1.1 1 0 0 1 1 1 1 BUD22 Zip PF02535.22 PIK39463.1 - 0.019 14.2 1.0 0.022 14.0 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 PIK39463.1 - 0.039 12.8 2.1 0.039 12.7 2.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RNA_pol_Rpc4 PF05132.14 PIK39463.1 - 0.077 13.4 8.0 0.12 12.8 8.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 PIK39463.1 - 0.15 10.8 4.0 0.19 10.4 4.0 1.1 1 0 0 1 1 1 0 Presenilin Astro_capsid_p PF12226.8 PIK39463.1 - 0.16 11.1 4.0 0.21 10.7 4.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF913 PF06025.12 PIK39463.1 - 0.36 9.7 3.6 0.42 9.5 3.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 PIK39463.1 - 0.37 10.5 2.0 0.53 10.0 2.0 1.3 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 PIK39463.1 - 0.47 8.7 9.6 0.6 8.3 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 PIK39463.1 - 1 9.1 14.8 1.4 8.7 14.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 PIK39463.1 - 1.2 7.0 3.6 1.4 6.7 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM176 PF14851.6 PIK39463.1 - 2 8.1 8.5 4.6 6.9 8.5 1.6 1 1 0 1 1 1 0 FAM176 family CobT PF06213.12 PIK39463.1 - 2.6 7.4 19.7 3.6 6.9 19.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pox_Ag35 PF03286.14 PIK39463.1 - 3.3 7.5 17.9 4.8 6.9 17.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TMEM119 PF15724.5 PIK39463.1 - 5 7.1 17.8 7.3 6.6 17.8 1.2 1 0 0 1 1 1 0 TMEM119 family Nop14 PF04147.12 PIK39463.1 - 8.8 4.4 18.3 10 4.2 18.3 1.0 1 0 0 1 1 1 0 Nop14-like family NACHT PF05729.12 PIK39464.1 - 1.4e-16 60.9 0.0 1.1e-15 58.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain C2-set_2 PF08205.12 PIK39464.1 - 5.3e-06 26.4 0.7 0.12 12.4 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK39464.1 - 1.1e-05 25.5 3.4 0.21 11.8 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin V-set domain C1-set PF07654.15 PIK39464.1 - 0.00015 22.1 5.1 0.026 14.9 0.4 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Protocadherin PF08374.11 PIK39464.1 - 0.00081 19.4 0.1 0.0017 18.4 0.1 1.4 1 0 0 1 1 1 1 Protocadherin Marek_A PF02124.15 PIK39464.1 - 0.0052 16.7 1.3 0.0052 16.7 1.3 1.8 2 0 0 2 2 2 1 Marek's disease glycoprotein A AAA_25 PF13481.6 PIK39464.1 - 0.0061 16.2 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ig PF00047.25 PIK39464.1 - 0.045 13.9 8.6 3.1 8.0 0.0 5.0 4 1 1 5 5 5 0 Immunoglobulin domain DUF5301 PF17225.3 PIK39464.1 - 0.072 13.5 0.3 0.55 10.7 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) EphA2_TM PF14575.6 PIK39464.1 - 0.14 13.1 0.1 0.57 11.1 0.1 2.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 PIK39464.1 - 0.15 12.0 1.3 0.43 10.5 1.3 1.7 1 0 0 1 1 1 0 Syndecan domain Lep_receptor_Ig PF06328.11 PIK39464.1 - 0.62 10.1 3.4 2.7 8.0 0.2 3.7 4 0 0 4 4 4 0 Ig-like C2-type domain Sulfotransfer_1 PF00685.27 PIK39466.1 - 4e-16 59.3 0.3 1.9e-13 50.5 0.4 2.1 2 0 0 2 2 2 2 Sulfotransferase domain Myosin_head PF00063.21 PIK39467.1 - 2.6e-138 462.2 1.6 3.5e-138 461.8 1.6 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_10 PF12846.7 PIK39467.1 - 0.015 14.3 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 PIK39467.1 - 0.019 15.3 0.0 0.06 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain RdRP PF05183.12 PIK39467.1 - 0.049 12.3 0.0 0.061 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA dependent RNA polymerase Zeta_toxin PF06414.12 PIK39467.1 - 0.056 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 PIK39467.1 - 0.16 12.3 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain LRR_8 PF13855.6 PIK39468.1 - 1.8e-21 75.7 28.6 1.5e-08 34.3 5.9 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK39468.1 - 7.8e-17 61.1 22.8 7.9e-07 29.3 4.7 5.1 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK39468.1 - 3.4e-09 36.0 19.5 3.7 8.5 0.9 7.4 7 0 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.6 PIK39468.1 - 2.5e-05 24.0 23.0 5.1 7.4 0.4 7.7 8 0 0 8 8 8 3 Leucine Rich repeat RsmF_methylt_CI PF17126.5 PIK39468.1 - 0.013 15.5 0.1 2.8 8.0 0.0 3.8 2 2 3 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain DUF1353 PF07087.11 PIK39469.1 - 0.03 14.0 0.1 0.076 12.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) zf-C2H2_4 PF13894.6 PIK39469.1 - 0.39 11.7 3.1 0.69 10.9 3.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger bZIP_1 PF00170.21 PIK39470.1 - 4.5e-10 39.5 8.1 4.5e-10 39.5 8.1 1.9 2 0 0 2 2 2 1 bZIP transcription factor CEP209_CC5 PF16574.5 PIK39470.1 - 0.039 14.1 2.7 0.063 13.5 2.7 1.3 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 TMF_DNA_bd PF12329.8 PIK39470.1 - 0.15 12.1 4.5 0.24 11.4 2.2 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ZapB PF06005.12 PIK39470.1 - 0.2 12.1 4.3 0.35 11.3 2.2 2.2 2 0 0 2 2 2 0 Cell division protein ZapB EF-1_beta_acid PF10587.9 PIK39470.1 - 0.23 12.0 1.6 0.44 11.0 0.4 2.2 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region Cnn_1N PF07989.11 PIK39470.1 - 0.27 11.4 3.9 0.59 10.3 2.2 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 PIK39470.1 - 0.35 10.6 4.0 2.9 7.7 1.8 2.3 2 0 0 2 2 2 0 Septum formation initiator bZIP_2 PF07716.15 PIK39470.1 - 9.6 6.4 15.5 1.2 9.3 10.5 2.2 2 1 0 2 2 2 0 Basic region leucine zipper PDZ PF00595.24 PIK39471.1 - 1.1e-36 125.0 0.7 2.2e-14 53.6 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK39471.1 - 2e-23 81.9 6.7 1.6e-07 31.1 0.3 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK39471.1 - 5.8e-16 58.6 1.0 5.3e-05 23.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 PIK39471.1 - 1.3e-09 38.0 0.0 4.9e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Guanylate kinase SH3_2 PF07653.17 PIK39471.1 - 0.0039 16.8 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Gal-3-0_sulfotr PF06990.11 PIK39472.1 - 3.2e-44 151.4 2.7 4.8e-44 150.9 2.7 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK39472.1 - 0.00014 22.3 0.5 0.00026 21.4 0.1 1.6 2 0 0 2 2 2 1 Sulfotransferase family DUF3692 PF12469.8 PIK39472.1 - 0.013 15.7 0.0 0.069 13.4 0.0 2.1 2 0 0 2 2 2 0 CRISPR-associated protein DUF4918 PF16265.5 PIK39473.1 - 9.7e-06 25.3 0.0 1.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4918) BUD22 PF09073.10 PIK39474.1 - 0.013 14.9 11.7 0.016 14.5 11.7 1.2 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.12 PIK39474.1 - 0.083 12.6 11.9 0.11 12.2 11.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Menin PF05053.13 PIK39474.1 - 1.9 6.8 6.4 2.3 6.5 6.4 1.0 1 0 0 1 1 1 0 Menin 7tm_1 PF00001.21 PIK39475.1 - 1.5e-44 152.4 4.9 1.9e-44 152.0 4.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39475.1 - 1.6e-09 37.8 7.6 2.3e-09 37.3 7.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39475.1 - 1.3e-08 34.6 4.5 1.3e-08 34.6 4.5 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK39475.1 - 0.0002 21.2 8.5 0.00055 19.8 8.5 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srw PF10324.9 PIK39475.1 - 0.0019 17.6 13.0 0.0028 17.0 12.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF4464 PF14713.6 PIK39477.1 - 3.8e-97 324.2 0.5 4.3e-97 324.1 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) Pkinase_Tyr PF07714.17 PIK39478.1 - 5e-50 170.2 0.0 3.5e-33 115.0 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK39478.1 - 2.5e-21 76.2 0.0 5.9e-11 42.2 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39479.1 - 3.5e-81 272.3 0.0 6.5e-81 271.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39479.1 - 4.6e-32 111.4 0.0 7.1e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK39479.1 - 0.0086 16.4 0.7 0.045 14.1 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain EphA2_TM PF14575.6 PIK39479.1 - 0.037 14.9 0.0 0.074 13.9 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.6 PIK39479.1 - 0.049 13.9 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) BatA PF07584.11 PIK39479.1 - 0.092 13.1 0.1 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal LPG_synthase_TM PF03706.13 PIK39479.1 - 0.1 12.1 0.1 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region NIDO PF06119.14 PIK39480.1 - 1.1e-20 74.3 0.5 3.6e-20 72.7 0.5 2.0 1 0 0 1 1 1 1 Nidogen-like AMOP PF03782.17 PIK39480.1 - 1.4e-15 57.7 6.1 2.9e-15 56.6 6.1 1.5 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK39480.1 - 1.9e-09 38.0 1.4 0.0014 18.9 0.0 3.0 4 0 0 4 4 4 2 von Willebrand factor type D domain TIG PF01833.24 PIK39480.1 - 3.1e-05 24.0 1.7 3.1e-05 24.0 1.7 2.4 2 0 0 2 2 2 1 IPT/TIG domain EGF_2 PF07974.13 PIK39480.1 - 5.2e-05 23.5 14.1 5.2e-05 23.5 14.1 4.7 4 0 0 4 4 4 1 EGF-like domain EGF PF00008.27 PIK39480.1 - 0.0036 17.6 12.5 0.0036 17.6 12.5 4.4 4 0 0 4 4 4 1 EGF-like domain Ycf34 PF10718.9 PIK39480.1 - 0.028 15.1 0.0 0.1 13.3 0.0 1.9 2 0 0 2 2 2 0 Hypothetical chloroplast protein Ycf34 Ig_3 PF13927.6 PIK39480.1 - 0.069 13.8 0.0 0.39 11.3 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Ribo_biogen_C PF04034.13 PIK39481.1 - 3.8e-54 181.8 0.0 6e-54 181.2 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 PIK39481.1 - 4.4e-12 45.6 1.7 1.2e-11 44.3 1.7 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI PAXIP1_C PF15364.6 PIK39481.1 - 0.0027 18.0 7.0 0.0048 17.2 7.0 1.4 1 0 0 1 1 1 1 PAXIP1-associated-protein-1 C term PTIP binding protein SDA1 PF05285.12 PIK39481.1 - 0.3 10.5 5.4 0.51 9.7 5.4 1.3 1 0 0 1 1 1 0 SDA1 Rad10 PF03834.14 PIK39482.1 - 4.6e-50 168.4 0.0 8.4e-50 167.6 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 PIK39482.1 - 5.7e-07 30.0 0.0 2.2e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 PIK39482.1 - 0.0052 16.9 0.0 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif ATF7IP_BD PF16788.5 PIK39482.1 - 1.2 9.2 15.1 2.4 8.2 15.1 1.4 1 0 0 1 1 1 0 ATF-interacting protein binding domain Macoilin PF09726.9 PIK39482.1 - 9.1 4.7 8.3 13 4.2 8.3 1.3 1 0 0 1 1 1 0 Macoilin family Ribosomal_S5 PF00333.20 PIK39483.1 - 1.8e-30 104.7 0.6 3.9e-30 103.6 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 PIK39483.1 - 1.1e-25 88.9 0.0 1.8e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DUF5320 PF17253.2 PIK39483.1 - 5.6 8.1 20.7 5.4 8.2 19.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5320) RVT_1 PF00078.27 PIK39484.1 - 1.1e-27 97.0 0.0 1.3e-27 96.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SAM_2 PF07647.17 PIK39485.1 - 4e-06 26.9 0.0 7.1e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK39485.1 - 9.4e-06 26.0 0.0 2.6e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MBOAT PF03062.19 PIK39486.1 - 1.5e-32 113.3 10.9 1.5e-32 113.3 10.9 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.11 PIK39486.1 - 0.017 15.4 0.1 0.047 14.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) Folliculin_C PF16692.5 PIK39487.1 - 1e-61 208.5 0.0 1.6e-61 207.9 0.0 1.3 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.8 PIK39487.1 - 2.1e-55 187.5 0.0 3.7e-55 186.7 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport DnaJ PF00226.31 PIK39489.1 - 3.6e-06 27.0 0.1 7e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Caprin-1_dimer PF18293.1 PIK39490.1 - 5.2e-34 117.2 0.5 1.1e-33 116.2 0.5 1.6 1 0 0 1 1 1 1 Caprin-1 dimerization domain V-set PF07686.17 PIK39491.1 - 0.0001 22.4 0.3 0.0003 20.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK39491.1 - 0.00056 19.8 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 PIK39491.1 - 0.017 15.7 2.0 2 9.1 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin domain 7TM_GPCR_Str PF10326.9 PIK39491.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str V-set PF07686.17 PIK39492.1 - 0.00015 21.9 0.8 0.00047 20.3 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK39492.1 - 0.00042 20.8 1.2 0.19 12.3 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain TMEM154 PF15102.6 PIK39492.1 - 0.0023 17.8 0.1 0.005 16.8 0.1 1.5 1 0 0 1 1 1 1 TMEM154 protein family DUF3169 PF11368.8 PIK39492.1 - 0.013 15.0 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) EphA2_TM PF14575.6 PIK39492.1 - 0.14 13.0 0.0 0.29 12.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ASFV_J13L PF05568.11 PIK39492.1 - 0.17 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Prominin PF05478.11 PIK39493.1 - 0.0097 13.9 0.1 0.019 12.9 0.1 1.4 1 0 0 1 1 1 1 Prominin Pox_A14 PF05767.12 PIK39493.1 - 0.09 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 7TM_GPCR_Str PF10326.9 PIK39493.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str V-set PF07686.17 PIK39494.1 - 3.2e-05 24.1 0.2 0.00011 22.3 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK39494.1 - 0.00063 20.3 2.1 0.056 14.0 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Sigma_reg_N PF13800.6 PIK39494.1 - 0.12 12.6 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Endonuc-BglII PF09195.11 PIK39494.1 - 0.14 12.0 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease BglII ASFV_J13L PF05568.11 PIK39494.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein zf-CCHC PF00098.23 PIK39496.1 - 5.9e-06 26.1 15.4 0.0035 17.4 3.3 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK39496.1 - 5.9e-05 22.7 13.8 0.18 11.6 0.3 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK39496.1 - 0.0031 17.3 0.2 0.0031 17.3 0.2 2.7 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK39496.1 - 3.7 7.9 11.9 1.2 9.4 6.4 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 PIK39497.1 - 2.1e-29 102.6 0.0 2.9e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK39498.1 - 0.00025 21.0 16.1 0.0077 16.3 3.3 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK39498.1 - 0.00035 20.3 6.3 0.0069 16.2 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK39498.1 - 0.00083 19.0 13.1 1.2 9.0 1.1 3.9 3 1 1 4 4 4 3 Zinc knuckle TPR_MLP1_2 PF07926.12 PIK39498.1 - 0.0019 18.2 0.6 0.0035 17.4 0.6 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein EzrA PF06160.12 PIK39498.1 - 0.012 13.9 0.2 0.016 13.4 0.2 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TSC22 PF01166.18 PIK39498.1 - 0.02 15.2 0.9 0.041 14.2 0.9 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF3450 PF11932.8 PIK39498.1 - 0.032 13.5 0.8 0.049 12.9 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Pox_A_type_inc PF04508.12 PIK39498.1 - 0.05 13.5 0.8 0.14 12.0 0.8 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Nnf1 PF03980.14 PIK39498.1 - 0.14 12.6 0.5 0.25 11.7 0.5 1.4 1 0 0 1 1 1 0 Nnf1 Spc7 PF08317.11 PIK39498.1 - 0.28 10.0 1.6 0.41 9.5 1.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IBR PF01485.21 PIK39498.1 - 4 7.8 11.5 6 7.2 9.0 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-CCHC_4 PF14392.6 PIK39500.1 - 7.6e-05 22.4 12.7 0.14 11.9 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK39500.1 - 0.0015 18.3 0.2 0.0015 18.3 0.2 3.2 3 1 0 3 3 3 2 Zinc knuckle zf-CCHC PF00098.23 PIK39500.1 - 0.017 15.2 18.0 0.023 14.8 0.2 4.3 4 0 0 4 4 4 0 Zinc knuckle DUF3449 PF11931.8 PIK39501.1 - 0.3 10.9 0.0 0.3 10.9 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3449) RVT_1 PF00078.27 PIK39502.1 - 3.4e-18 66.0 0.1 4.7e-18 65.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UxaE PF16257.5 PIK39502.1 - 0.035 12.8 0.0 0.048 12.3 0.0 1.2 1 0 0 1 1 1 0 tagaturonate epimerase UPF0149 PF03695.13 PIK39502.1 - 0.2 11.9 0.0 0.32 11.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Integrase_H2C2 PF17921.1 PIK39503.1 - 7.1e-19 67.7 0.2 1.9e-18 66.3 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK39503.1 - 3.2e-15 56.4 0.1 2.5e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK39503.1 - 2.8e-06 27.4 0.0 1.3e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Myb_DNA-binding PF00249.31 PIK39503.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Integrase_Zn PF02022.19 PIK39503.1 - 0.52 10.3 2.6 20 5.3 0.1 2.7 2 0 0 2 2 2 0 Integrase Zinc binding domain zf-CCHC PF00098.23 PIK39504.1 - 0.00038 20.4 15.2 0.00065 19.7 0.2 3.8 4 0 0 4 4 4 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK39504.1 - 0.0026 17.6 3.2 1.4 8.8 0.6 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK39504.1 - 0.0099 15.8 10.6 0.22 11.5 1.0 3.3 3 1 1 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK39504.1 - 0.022 14.6 0.2 0.022 14.6 0.2 2.6 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK39504.1 - 0.022 14.5 0.8 0.022 14.5 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK39504.1 - 0.41 10.4 9.4 5 7.0 0.4 3.2 2 1 1 3 3 3 0 Zinc knuckle MULE PF10551.9 PIK39505.1 - 8.7e-07 29.3 0.3 2.3e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain DUF1593 PF07632.11 PIK39505.1 - 0.021 14.3 0.3 0.033 13.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) ALS2CR8 PF15299.6 PIK39505.1 - 0.092 12.6 0.1 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 RVT_1 PF00078.27 PIK39506.1 - 1.2e-07 31.5 0.0 0.00021 20.9 0.0 3.0 2 1 1 3 3 3 3 Reverse transcriptase (RNA-dependent DNA polymerase) DED PF01335.21 PIK39508.1 - 0.048 14.0 0.0 0.063 13.6 0.0 1.2 1 0 0 1 1 1 0 Death effector domain BTB_2 PF02214.22 PIK39509.1 - 1.2e-09 38.3 1.2 2.1e-08 34.4 0.4 2.6 2 1 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK39509.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 BTB And C-terminal Kelch DUF3808 PF10300.9 PIK39510.1 - 1.8e-50 172.1 0.7 2.2e-50 171.8 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_1 PF00515.28 PIK39510.1 - 0.00045 19.9 2.4 1.7 8.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39510.1 - 0.00052 20.3 0.2 2.2 8.6 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39510.1 - 0.0012 18.8 0.3 20 5.6 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK39510.1 - 0.01 15.7 0.5 5.3 7.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK39510.1 - 0.03 15.0 0.6 4.2e+02 1.9 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39510.1 - 0.18 11.9 0.7 17 5.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 PIK39511.1 - 4.8e-89 298.1 0.1 6.2e-89 297.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39511.1 - 1e-47 162.7 0.0 1.4e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 PIK39511.1 - 2.4e-05 23.5 1.1 2.6e-05 23.4 0.2 1.4 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 PIK39511.1 - 0.0011 18.3 0.2 0.0017 17.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK39511.1 - 0.056 12.2 0.0 0.095 11.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 PIK39511.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Kinase-like SH2 PF00017.24 PIK39512.1 - 3.2e-41 139.3 0.0 2e-19 69.4 0.0 3.3 2 1 1 3 3 3 3 SH2 domain Cbl_N3 PF02762.14 PIK39512.1 - 0.0028 17.5 0.0 1.4 8.8 0.0 2.7 3 0 0 3 3 3 2 CBL proto-oncogene N-terminus, SH2-like domain RT_RNaseH_2 PF17919.1 PIK39513.1 - 3.3e-31 107.3 0.1 6.7e-31 106.3 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK39513.1 - 1.5e-29 102.3 0.0 2.7e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK39513.1 - 3.3e-17 62.3 0.7 6.7e-17 61.3 0.7 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK39513.1 - 2.1e-08 34.4 0.0 5e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK39513.1 - 1.9e-06 28.0 0.2 3.6e-06 27.1 0.2 1.5 1 0 0 1 1 1 1 H2C2 zinc finger NERD PF08378.11 PIK39514.1 - 0.0096 16.4 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Nuclease-related domain DUF2075 PF09848.9 PIK39514.1 - 0.016 14.5 0.2 0.079 12.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK39514.1 - 0.14 12.5 0.0 0.43 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Cwf_Cwc_15 PF04889.12 PIK39514.1 - 0.56 9.9 6.3 0.44 10.2 2.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Phospholip_A2_1 PF00068.19 PIK39516.1 - 1.1e-25 90.2 10.5 1.6e-25 89.7 10.5 1.2 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 PIK39516.1 - 0.052 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus coat protein VP1 YusW PF14039.6 PIK39517.1 - 2.8 8.5 9.8 0.21 12.1 1.4 2.9 2 1 1 3 3 3 0 YusW-like protein Metallophos PF00149.28 PIK39518.1 - 3.5e-21 76.6 0.0 2.1e-20 74.1 0.0 1.8 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase TROVE PF05731.11 PIK39519.1 - 1e-23 84.1 0.2 5.4e-21 75.2 0.2 3.1 1 1 0 1 1 1 1 TROVE domain VWA_3 PF13768.6 PIK39519.1 - 5.7e-06 26.4 0.0 1.3e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4363 PF14276.6 PIK39519.1 - 0.00062 19.9 0.8 0.0031 17.6 0.8 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4363) TipAS PF07739.13 PIK39519.1 - 0.0029 18.1 0.4 0.0063 17.0 0.4 1.6 1 0 0 1 1 1 1 TipAS antibiotic-recognition domain DUF2087 PF09860.9 PIK39519.1 - 0.0098 16.0 0.0 0.045 13.9 0.0 2.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2087) VWA_CoxE PF05762.14 PIK39519.1 - 0.024 14.0 0.0 0.072 12.5 0.0 1.8 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein DUF58 PF01882.18 PIK39519.1 - 0.04 14.2 0.0 0.3 11.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF58 VWA_2 PF13519.6 PIK39519.1 - 0.081 13.6 0.2 0.56 10.9 0.0 2.4 3 0 0 3 3 3 0 von Willebrand factor type A domain RisS_PPD PF16524.5 PIK39519.1 - 0.085 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS FERM_M PF00373.18 PIK39520.1 - 2.3e-13 50.6 0.7 7.7e-13 48.9 0.0 2.3 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 PIK39520.1 - 1.3e-11 44.2 0.1 3e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 PIK39520.1 - 2.9e-09 37.2 0.1 8.3e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 PIK39520.1 - 9.2e-08 32.1 9.3 9.2e-08 32.1 9.3 3.1 3 0 0 3 3 3 1 FERM adjacent (FA) Pkinase PF00069.25 PIK39521.1 - 8.3e-62 208.9 0.0 1.6e-61 208.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39521.1 - 7.1e-39 133.6 0.0 1.6e-38 132.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 PIK39521.1 - 7e-33 112.6 22.8 2.1e-13 50.2 4.3 3.7 3 0 0 3 3 3 3 Hr1 repeat Pkinase_C PF00433.24 PIK39521.1 - 9.9e-10 39.0 0.3 3e-09 37.4 0.3 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 PIK39521.1 - 1.7e-07 30.9 0.0 1.2e-06 28.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Uds1 PF15456.6 PIK39521.1 - 0.0013 18.8 21.0 0.044 14.0 0.6 3.9 4 0 0 4 4 4 3 Up-regulated During Septation Haspin_kinase PF12330.8 PIK39521.1 - 0.014 14.4 0.0 0.014 14.4 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain MscS_porin PF12795.7 PIK39521.1 - 1.3 8.5 9.2 0.53 9.8 4.3 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain FliD_N PF02465.18 PIK39521.1 - 4.3 8.1 6.1 4.8 7.9 1.8 2.8 2 2 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.12 PIK39521.1 - 4.6 7.8 5.6 91 3.6 2.3 3.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 PIK39521.1 - 6.1 6.1 10.0 44 3.3 10.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SRAP PF02586.14 PIK39522.1 - 2.7e-46 157.9 0.4 4.1e-46 157.3 0.4 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) SRAP PF02586.14 PIK39523.1 - 8.7e-06 25.4 0.2 3.2e-05 23.6 0.0 2.0 2 1 1 3 3 3 1 SOS response associated peptidase (SRAP) RdgC PF04381.12 PIK39523.1 - 0.041 13.1 2.4 2 7.6 0.2 2.1 1 1 1 2 2 2 0 Putative exonuclease, RdgC Ribonucleas_3_3 PF14622.6 PIK39524.1 - 1e-42 145.3 0.7 1.1e-24 87.0 0.0 4.2 3 1 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 PIK39524.1 - 2.2e-34 118.2 3.8 3.2e-20 72.7 0.1 4.2 3 1 0 3 3 3 2 Ribonuclease III domain dsrm PF00035.26 PIK39524.1 - 2.3e-08 34.6 0.1 6.1e-08 33.3 0.1 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Hrs_helical PF12210.8 PIK39524.1 - 0.043 14.4 0.5 0.11 13.0 0.5 1.7 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate zf-C2H2_4 PF13894.6 PIK39525.1 - 8e-12 44.9 93.0 0.021 15.6 0.3 13.4 14 0 0 14 14 14 9 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK39525.1 - 6.6e-08 32.6 90.3 0.011 16.1 0.8 12.4 13 0 0 13 13 13 7 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 PIK39525.1 - 1.9e-07 30.7 3.4 1.9e-07 30.7 3.4 8.5 10 0 0 10 10 10 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 PIK39525.1 - 0.001 19.3 26.5 0.079 13.3 0.5 5.6 5 1 0 5 5 5 3 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 PIK39525.1 - 0.0049 16.8 45.9 0.062 13.3 0.1 8.9 9 0 0 9 9 9 4 C2H2-type zinc finger zf-Di19 PF05605.12 PIK39525.1 - 0.039 14.2 0.5 0.039 14.2 0.5 9.2 6 1 4 10 10 10 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK39525.1 - 0.24 11.7 0.0 0.24 11.7 0.0 8.2 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK39525.1 - 1.3 9.4 53.7 1.4 9.3 0.0 10.4 5 4 4 10 10 10 0 C2H2 type zinc-finger (2 copies) DUF5072 PF16807.5 PIK39526.1 - 0.12 12.5 0.2 0.32 11.1 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5072) HrpA_pilin PF09589.10 PIK39526.1 - 9.2 7.1 8.2 7.8 7.3 2.5 2.5 2 0 0 2 2 2 0 HrpA pilus formation protein BppL_N PF18338.1 PIK39527.1 - 1.6e-18 65.6 25.9 0.0017 18.0 2.4 9.2 9 1 0 9 9 9 6 Lower baseplate protein N-terminal domain EPTP PF03736.17 PIK39527.1 - 3.5e-07 30.1 5.1 0.02 14.9 0.1 4.6 5 0 0 5 5 5 2 EPTP domain rve PF00665.26 PIK39528.1 - 1.7e-08 34.7 0.1 7.3e-07 29.4 0.0 3.0 3 0 0 3 3 3 1 Integrase core domain HTH_7 PF02796.15 PIK39528.1 - 0.0003 20.8 0.2 0.0011 19.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 PIK39528.1 - 0.08 12.7 0.0 0.37 10.6 0.0 2.3 1 0 0 1 1 1 0 Helix-turn-helix domain PRESAN PF09687.10 PIK39528.1 - 0.47 11.0 2.5 5.5 7.6 0.4 2.7 3 0 0 3 3 3 0 Plasmodium RESA N-terminal HisKA PF00512.25 PIK39528.1 - 0.69 10.0 4.0 20 5.3 1.2 2.9 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain CCDC158 PF15921.5 PIK39530.1 - 7.3e-13 47.3 31.1 8.5e-13 47.1 31.1 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 158 ERM PF00769.19 PIK39530.1 - 0.27 11.0 52.8 0.021 14.7 21.4 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FlaC_arch PF05377.11 PIK39531.1 - 0.03 14.7 2.3 0.03 14.7 2.3 7.7 7 2 1 8 8 8 0 Flagella accessory protein C (FlaC) kleA_kleC PF17383.2 PIK39531.1 - 0.47 10.8 0.0 0.47 10.8 0.0 4.7 4 2 1 5 5 5 0 Uncharacterized KorC regulated protein A DUF5531 PF17671.1 PIK39532.1 - 0.38 10.6 2.8 0.26 11.1 0.4 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5531) YlqD PF11068.8 PIK39532.1 - 1.9 8.9 12.4 1.5 9.2 1.5 2.6 2 1 0 2 2 2 0 YlqD protein CLCA PF08434.11 PIK39533.1 - 3.6e-52 177.3 0.0 5.4e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK39533.1 - 3e-14 53.6 0.0 5.9e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK39533.1 - 2.3e-07 31.4 0.0 7.1e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF2970 PF11174.8 PIK39533.1 - 0.08 12.8 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) TMEM154 PF15102.6 PIK39533.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Transglut_N PF00868.20 PIK39534.1 - 1.9e-35 121.7 0.4 6.8e-32 110.3 0.0 3.3 3 1 0 3 3 3 2 Transglutaminase family Transglut_C PF00927.22 PIK39534.1 - 3.9e-29 100.9 2.0 8.6e-14 51.6 0.0 2.8 2 1 1 3 3 3 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 PIK39534.1 - 3.4e-14 53.2 0.3 7e-14 52.2 0.3 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF11 PF01345.18 PIK39534.1 - 0.052 13.9 0.4 5.5 7.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF11 LRR_8 PF13855.6 PIK39535.1 - 6e-24 83.6 17.6 5.7e-08 32.4 0.1 4.5 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK39535.1 - 1.9e-10 40.8 9.7 4e-05 23.6 4.3 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK39535.1 - 2.8e-09 37.1 22.2 0.058 13.8 7.4 6.1 2 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK39535.1 - 0.00017 21.2 1.1 0.7 9.4 1.1 2.9 1 1 1 2 2 2 2 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK39535.1 - 0.0031 17.2 16.7 0.018 14.8 3.6 2.6 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK39535.1 - 0.0044 17.0 8.6 0.36 10.8 0.5 2.4 2 0 0 2 2 2 2 Nine Cysteines Domain of family 3 GPCR LRR_1 PF00560.33 PIK39535.1 - 0.25 12.0 11.0 66 4.7 0.0 6.2 4 2 0 4 4 4 0 Leucine Rich Repeat Beta-lactamase PF00144.24 PIK39536.1 - 4.7e-55 187.1 0.0 7.1e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_M24 PF00557.24 PIK39537.1 - 3.5e-29 102.0 0.2 4e-29 101.8 0.2 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 RVT_1 PF00078.27 PIK39538.1 - 5.1e-29 101.4 0.0 7.3e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK39538.1 - 6.3e-10 39.0 0.1 1.7e-09 37.6 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PHD PF00628.29 PIK39538.1 - 0.0051 16.7 7.0 0.0051 16.7 7.0 2.4 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 PIK39539.1 - 5e-09 35.9 7.4 1.7e-08 34.2 4.7 2.9 3 0 0 3 3 3 1 PHD-finger UCH PF00443.29 PIK39539.1 - 0.00022 20.8 0.0 0.00069 19.2 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PHD_2 PF13831.6 PIK39539.1 - 0.025 14.1 0.6 0.025 14.1 0.6 2.5 2 0 0 2 2 2 0 PHD-finger UCH_1 PF13423.6 PIK39539.1 - 0.034 13.7 0.1 0.057 13.0 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PHD_4 PF16866.5 PIK39539.1 - 0.24 11.5 3.9 2.6 8.2 1.9 2.7 2 0 0 2 2 2 0 PHD-finger WD40 PF00400.32 PIK39540.1 - 0.0016 19.2 0.7 1.2 10.1 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat eIF2A PF08662.11 PIK39540.1 - 0.038 13.9 0.0 2.7 7.8 0.0 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Glyco_transf_29 PF00777.18 PIK39541.1 - 0.00053 19.5 0.0 0.00088 18.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK39542.1 - 1.2e-58 198.6 0.1 1.5e-58 198.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK39543.1 - 4.8e-25 88.5 0.4 5.2e-25 88.4 0.4 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Retrotrans_gag PF03732.17 PIK39544.1 - 0.048 13.9 0.1 3.4 8.0 0.0 2.4 2 1 0 2 2 2 0 Retrotransposon gag protein ELK PF03789.13 PIK39544.1 - 0.11 12.6 0.6 0.29 11.2 0.6 1.7 1 0 0 1 1 1 0 ELK domain Yip1 PF04893.17 PIK39545.1 - 4.5e-08 33.0 0.4 5.5e-08 32.7 0.4 1.1 1 0 0 1 1 1 1 Yip1 domain DnaJ PF00226.31 PIK39546.1 - 1.7e-22 79.3 0.2 1.7e-22 79.3 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 PIK39546.1 - 7e-10 38.9 2.8 7e-10 38.9 2.8 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK39546.1 - 4.9e-07 30.0 3.6 0.0086 16.4 0.5 3.1 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK39546.1 - 1.4e-06 28.5 1.7 1.4e-06 28.5 1.7 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 PIK39546.1 - 0.00079 20.1 4.6 0.44 11.5 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK39546.1 - 0.0047 17.3 8.1 0.45 11.1 1.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 PIK39546.1 - 2.8 8.0 6.0 13 5.9 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger 2OG-FeII_Oxy_2 PF13532.6 PIK39547.1 - 3.8e-10 40.3 0.0 2e-09 37.9 0.0 1.8 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 PIK39548.1 - 3.1e-17 62.6 8.9 0.00043 21.0 0.2 9.1 10 0 0 10 10 10 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK39548.1 - 2.6e-06 27.6 0.2 2.3 8.6 0.1 6.3 3 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK39548.1 - 2.8e-05 23.6 0.2 0.00055 19.3 0.0 2.7 2 1 0 2 2 2 1 WD40-like domain Lactonase PF10282.9 PIK39548.1 - 0.00019 20.8 0.0 0.36 10.1 0.0 3.0 2 1 0 3 3 3 2 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 PIK39548.1 - 0.0017 18.8 0.8 1.3 9.6 0.0 4.8 5 0 0 5 5 5 1 PQQ-like domain Nup160 PF11715.8 PIK39548.1 - 0.019 13.7 0.6 3.7 6.1 0.0 3.0 2 1 1 3 3 3 0 Nucleoporin Nup120/160 ATG16 PF08614.11 PIK39549.1 - 5.2e-05 23.6 29.1 5.2e-05 23.6 29.1 5.4 1 1 3 5 5 5 2 Autophagy protein 16 (ATG16) FPP PF05911.11 PIK39549.1 - 0.00028 19.2 22.1 0.00028 19.2 22.1 4.1 1 1 3 4 4 4 1 Filament-like plant protein, long coiled-coil ADIP PF11559.8 PIK39549.1 - 0.0032 17.6 10.8 0.0032 17.6 10.8 6.5 3 2 3 6 6 6 2 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 PIK39549.1 - 0.0077 16.2 10.3 0.0077 16.2 10.3 9.8 4 3 5 10 10 10 3 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 PIK39549.1 - 0.012 15.6 5.9 0.012 15.6 5.9 6.6 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) Trans_reg_C PF00486.28 PIK39549.1 - 0.014 15.4 4.7 4.8 7.3 0.2 4.1 2 1 1 3 3 3 0 Transcriptional regulatory protein, C terminal Fib_alpha PF08702.10 PIK39549.1 - 0.016 15.4 8.2 0.016 15.4 8.2 6.4 1 1 4 6 6 6 0 Fibrinogen alpha/beta chain family YabA PF06156.13 PIK39549.1 - 0.017 15.8 10.4 0.017 15.8 10.4 7.7 2 2 4 6 6 6 0 Initiation control protein YabA DUF3584 PF12128.8 PIK39549.1 - 0.47 7.9 95.4 0.84 7.1 23.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) G-gamma PF00631.22 PIK39549.1 - 1.7 8.7 0.0 1.7 8.7 0.0 5.5 6 1 1 7 7 7 0 GGL domain Steroid_dh PF02544.16 PIK39550.1 - 4.5e-29 101.4 1.7 4.5e-29 101.4 1.7 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 PIK39550.1 - 4.4e-06 26.3 0.1 7.1e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 PIK39550.1 - 0.02 14.7 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HalX PF08663.10 PIK39552.1 - 0.0058 16.9 0.1 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 HalX domain DUF1887 PF09002.11 PIK39552.1 - 0.082 11.6 0.0 0.088 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) Spc7 PF08317.11 PIK39553.1 - 0.72 8.7 93.3 0.17 10.7 21.6 4.4 1 1 2 4 4 4 0 Spc7 kinetochore protein APG6_N PF17675.1 PIK39553.1 - 2 8.9 101.8 0.24 11.9 20.4 5.4 1 1 4 5 5 5 0 Apg6 coiled-coil region Med26 PF08711.11 PIK39554.1 - 2.3e-11 43.5 1.2 8.2e-11 41.8 1.2 2.0 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Med26_C PF15693.5 PIK39554.1 - 2.3e-07 31.2 7.8 2.3e-07 31.2 7.8 3.1 1 1 1 2 2 2 1 Mediator complex subunit 26 C-terminal ZZ PF00569.17 PIK39555.1 - 5.4e-13 48.5 11.2 9.3e-13 47.8 11.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_3 PF09069.11 PIK39555.1 - 8.3e-08 32.5 0.3 3e-07 30.8 0.3 1.9 1 0 0 1 1 1 1 EF-hand Cnn_1N PF07989.11 PIK39555.1 - 0.31 11.2 7.1 0.94 9.7 7.1 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TerB_C PF15615.6 PIK39555.1 - 0.59 10.4 7.8 1.1 9.5 7.8 1.4 1 0 0 1 1 1 0 TerB-C domain HALZ PF02183.18 PIK39555.1 - 1 9.6 9.2 1.3 9.3 1.8 3.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 PIK39555.1 - 2 8.6 18.1 0.39 10.9 1.8 3.6 3 0 0 3 3 3 0 bZIP transcription factor SOGA PF11365.8 PIK39555.1 - 3.4 8.8 11.2 4 8.6 0.8 3.1 2 1 1 3 3 3 0 Protein SOGA LsmAD PF06741.13 PIK39557.1 - 1.7e-13 50.9 3.1 3.3e-13 50.0 3.1 1.5 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 PIK39557.1 - 2.5e-10 40.3 0.3 5.2e-10 39.3 0.3 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 PIK39557.1 - 0.00079 19.1 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 PIK39557.1 - 0.0052 16.9 0.1 0.013 15.6 0.1 1.7 1 0 0 1 1 1 1 Scd6-like Sm domain zf-C3HC4_3 PF13920.6 PIK39558.1 - 7.9e-12 44.8 4.9 1.1e-11 44.4 4.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK39558.1 - 7.1e-11 41.8 6.4 1e-10 41.3 6.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK39558.1 - 7.2e-10 39.0 8.7 1e-09 38.6 8.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK39558.1 - 2.3e-09 37.0 7.6 3.4e-09 36.4 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK39558.1 - 2e-08 33.9 5.4 2.9e-08 33.4 5.4 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK39558.1 - 4.9e-08 32.9 5.0 2.1e-07 30.8 5.4 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK39558.1 - 1.8e-07 31.0 5.9 2.8e-07 30.4 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 PIK39558.1 - 1.2e-05 25.5 7.2 2.2e-05 24.6 7.2 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK39558.1 - 2.9e-05 24.0 2.6 4.9e-05 23.3 2.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 PIK39558.1 - 5.3e-05 23.3 7.0 8e-05 22.7 7.0 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 PIK39558.1 - 0.0029 17.6 3.0 0.0042 17.0 3.0 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Rtf2 PF04641.12 PIK39558.1 - 0.0072 15.7 0.1 0.0092 15.4 0.1 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger IBR PF01485.21 PIK39558.1 - 0.023 14.9 7.8 0.18 12.1 3.0 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_11 PF17123.5 PIK39558.1 - 0.038 13.7 2.8 0.038 13.7 2.8 1.8 2 0 0 2 2 2 0 RING-like zinc finger YuzL PF14115.6 PIK39558.1 - 0.041 14.4 0.9 0.17 12.4 0.5 2.1 2 0 0 2 2 2 0 YuzL-like protein zf-UDP PF14569.6 PIK39558.1 - 0.2 11.8 2.9 0.5 10.5 2.9 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger TerY_C PF15616.6 PIK39558.1 - 0.22 11.6 3.1 0.37 10.9 3.1 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_4 PF14570.6 PIK39558.1 - 0.26 11.1 6.6 0.55 10.1 6.6 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 PIK39558.1 - 0.34 11.1 4.9 1.4 9.1 4.9 1.9 1 1 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 PIK39558.1 - 0.36 10.5 5.2 0.59 9.8 5.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 PIK39558.1 - 8.9 6.6 10.6 76 3.6 10.6 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain Endostatin PF06482.11 PIK39559.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin EIF4E-T PF10477.9 PIK39560.1 - 4.1e-46 158.1 47.8 2.4e-23 82.9 32.1 4.0 2 1 1 3 3 3 3 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Exo_endo_phos PF03372.23 PIK39561.1 - 0.002 17.7 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK39562.1 - 2.9e-29 102.2 0.1 7.8e-29 100.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK39562.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Med18 protein LCM PF04072.14 PIK39564.1 - 1.2e-27 97.1 0.0 1.9e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 PIK39564.1 - 5.1e-22 77.6 1.2 2.1e-07 30.8 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK39564.1 - 9.5e-18 63.8 1.8 4.8e-06 26.7 0.0 5.2 3 1 2 5 5 5 4 Kelch motif Kelch_3 PF13415.6 PIK39564.1 - 3.8e-17 62.1 0.1 0.0026 18.0 0.0 5.5 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK39564.1 - 1.2e-10 41.1 0.1 0.025 14.6 0.0 5.7 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 PIK39564.1 - 0.00047 20.0 0.3 1.5 8.9 0.1 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 PIK39564.1 - 0.00058 19.4 0.3 0.11 12.0 0.0 3.6 5 0 0 5 5 5 1 Kelch motif RAG2 PF03089.14 PIK39564.1 - 0.023 13.7 0.0 0.047 12.7 0.0 1.5 1 0 0 1 1 1 0 Recombination activating protein 2 A2M PF00207.22 PIK39564.1 - 0.18 11.7 0.0 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 Alpha-2-macroglobulin family bZIP_1 PF00170.21 PIK39565.1 - 2.1e-19 69.3 14.3 3.3e-19 68.7 14.3 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK39565.1 - 2.1e-07 30.9 14.0 3.4e-07 30.2 14.0 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 PIK39565.1 - 0.0022 18.5 6.9 0.0038 17.7 6.9 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 PIK39565.1 - 0.0062 16.1 2.2 0.0086 15.7 2.2 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 pKID PF02173.17 PIK39565.1 - 0.011 15.1 0.1 0.028 13.9 0.0 1.8 2 0 0 2 2 2 0 pKID domain TPR_MLP1_2 PF07926.12 PIK39565.1 - 0.013 15.6 6.5 0.028 14.5 6.5 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Phage_Gp23 PF10669.9 PIK39565.1 - 0.075 13.4 3.3 0.11 12.9 3.3 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) OSR1_C PF12202.8 PIK39566.1 - 9.9e-23 80.1 0.3 2e-22 79.2 0.3 1.5 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Integrin_alpha2 PF08441.12 PIK39567.1 - 5.3e-55 187.2 0.1 6.3e-55 186.9 0.1 1.1 1 0 0 1 1 1 1 Integrin alpha Pkinase PF00069.25 PIK39567.1 - 1.7e-39 135.8 0.0 3.3e-39 134.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39567.1 - 2e-33 115.8 0.0 5e-33 114.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK39567.1 - 0.0014 17.5 0.0 0.0025 16.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK39567.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF11 PF01345.18 PIK39567.1 - 0.053 13.8 0.1 0.46 10.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF11 FG-GAP PF01839.23 PIK39568.1 - 3.1e-16 59.2 16.5 2.2e-08 34.1 4.9 3.8 4 0 0 4 4 4 2 FG-GAP repeat VCBS PF13517.6 PIK39568.1 - 5.9e-10 39.6 13.1 6.2e-08 33.1 7.4 3.0 1 1 3 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Monellin PF09200.10 PIK39568.1 - 0.012 15.4 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 Monellin TcdB_toxin_midN PF12256.8 PIK39568.1 - 0.026 13.9 0.5 5.3 6.4 0.1 2.2 1 1 1 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region PABP PF00658.18 PIK39569.1 - 3.8e-42 142.3 5.7 6.1e-15 55.2 0.3 3.1 3 0 0 3 3 3 3 Poly-adenylate binding protein, unique domain Exo84_C PF16528.5 PIK39569.1 - 0.092 12.6 1.3 0.21 11.4 0.5 1.8 1 1 1 2 2 2 0 Exocyst component 84 C-terminal CAP PF00188.26 PIK39570.1 - 3.2e-21 76.5 0.6 5.1e-21 75.8 0.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family MOSC PF03473.17 PIK39570.1 - 0.032 14.3 0.1 0.053 13.5 0.1 1.4 1 0 0 1 1 1 0 MOSC domain zf-MIZ PF02891.20 PIK39571.1 - 1e-13 50.8 3.7 1.8e-13 50.0 3.7 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 PIK39571.1 - 0.0023 17.7 2.9 0.0049 16.7 2.9 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit ATG16 PF08614.11 PIK39572.1 - 0.14 12.4 1.1 0.23 11.7 1.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ACT_5 PF13710.6 PIK39573.1 - 0.0027 17.5 0.7 0.0069 16.2 0.7 1.7 1 0 0 1 1 1 1 ACT domain DUF493 PF04359.14 PIK39573.1 - 0.15 12.7 0.0 3.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF493) RVT_1 PF00078.27 PIK39574.1 - 6.2e-20 71.7 0.1 1.1e-19 70.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 PIK39574.1 - 0.0014 18.3 0.1 0.0042 16.8 0.0 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 PIK39574.1 - 0.03 14.4 0.6 0.03 14.4 0.6 2.8 3 0 0 3 3 3 0 Zinc knuckle Retrotrans_gag PF03732.17 PIK39574.1 - 0.043 14.1 0.0 0.14 12.5 0.0 1.9 1 0 0 1 1 1 0 Retrotransposon gag protein RT_RNaseH PF17917.1 PIK39575.1 - 7.2e-31 106.6 0.2 1.8e-30 105.3 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK39575.1 - 2.9e-26 92.0 0.0 6.5e-26 90.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK39575.1 - 3.2e-26 91.3 0.2 1.3e-25 89.4 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DNA_ligase_A_M PF01068.21 PIK39575.1 - 0.03 14.0 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain rve_3 PF13683.6 PIK39575.1 - 0.13 12.1 0.3 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain SBF PF01758.16 PIK39579.1 - 6.4e-13 48.8 9.3 1.4e-12 47.8 9.3 1.5 1 1 0 1 1 1 1 Sodium Bile acid symporter family GSAP-16 PF14959.6 PIK39580.1 - 9.6e-24 83.3 1.1 2.2e-23 82.2 1.1 1.6 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term WD40 PF00400.32 PIK39582.1 - 1.8e-15 57.0 14.6 4e-06 27.5 0.3 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK39582.1 - 0.00033 20.9 0.0 0.024 14.9 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK39582.1 - 0.043 12.5 1.3 0.14 10.7 1.3 1.7 1 1 0 1 1 1 0 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK39582.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A HALZ PF02183.18 PIK39584.1 - 0.022 14.9 6.8 0.22 11.8 0.8 3.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper RE_NgoFVII PF09565.10 PIK39584.1 - 0.37 10.1 12.4 0.049 12.9 6.9 2.1 1 1 1 2 2 2 0 NgoFVII restriction endonuclease DUF4407 PF14362.6 PIK39584.1 - 0.53 9.6 14.6 0.87 8.9 14.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 PIK39584.1 - 0.62 8.9 8.9 0.91 8.4 8.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Ax_dynein_light PF10211.9 PIK39584.1 - 7.5 6.5 27.8 0.26 11.2 16.1 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain LepA_C PF06421.12 PIK39585.1 - 1.2e-49 167.0 4.4 1.5e-49 166.6 4.4 1.1 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 PIK39585.1 - 9e-14 51.3 0.0 1.5e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU PF00009.27 PIK39587.1 - 2.3e-34 118.6 0.0 2.3e-34 118.6 0.0 2.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 PIK39587.1 - 4.8e-20 71.6 2.8 4.8e-20 71.6 0.2 2.5 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 PIK39587.1 - 6.1e-16 58.1 0.4 1.7e-15 56.7 0.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 PIK39587.1 - 2e-09 37.7 10.8 3.7e-06 27.2 0.3 3.6 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 PIK39587.1 - 9.3e-07 28.9 0.3 1.2e-05 25.4 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 PIK39587.1 - 0.0015 18.7 0.0 0.0043 17.3 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 PIK39587.1 - 0.0029 17.4 0.0 0.0029 17.4 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Ribosomal_S3_C PF00189.20 PIK39588.1 - 6.7e-24 84.2 0.8 2.2e-23 82.6 0.5 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 PIK39588.1 - 1.3e-11 44.2 0.1 2e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 KH domain Tmemb_185A PF10269.9 PIK39589.1 - 2.1e-57 194.7 19.4 2.6e-57 194.4 19.4 1.1 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Ninjurin PF04923.12 PIK39589.1 - 0.11 12.5 2.8 4.3 7.3 0.0 2.6 2 1 0 2 2 2 0 Ninjurin DUF4131 PF13567.6 PIK39589.1 - 0.83 9.3 12.9 0.23 11.1 0.4 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) DUF2975 PF11188.8 PIK39589.1 - 4.4 7.2 12.7 7.5 6.5 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) TraB PF01963.17 PIK39590.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 TraB family Abhydrolase_3 PF07859.13 PIK39591.1 - 3.8e-34 118.4 0.0 7.5e-28 97.8 0.1 2.9 2 1 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 PIK39591.1 - 0.0092 14.9 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase TMEM171 PF15471.6 PIK39591.1 - 0.14 11.1 0.5 0.25 10.3 0.5 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 Ig_3 PF13927.6 PIK39592.1 - 6.5e-38 129.2 1.7 1.6e-11 44.6 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK39592.1 - 4.6e-31 106.7 0.9 8.8e-09 35.3 0.0 6.4 4 2 1 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK39592.1 - 1.3e-27 96.0 0.1 1.3e-07 31.9 0.0 5.2 3 2 2 5 5 5 4 Immunoglobulin domain ig PF00047.25 PIK39592.1 - 4.3e-22 78.1 0.1 3.4e-06 27.1 0.0 5.6 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.12 PIK39592.1 - 1e-16 60.8 0.1 3.5e-10 39.8 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK39592.1 - 1.6e-14 54.0 0.9 0.00015 21.9 0.0 6.0 4 1 2 6 6 6 3 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK39592.1 - 9.8e-09 35.4 0.0 0.42 10.9 0.0 4.9 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK39592.1 - 8.1e-07 29.3 0.0 0.023 15.1 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK39592.1 - 0.00087 18.8 0.0 0.43 10.2 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.6 PIK39592.1 - 0.00098 19.0 0.3 0.0023 17.8 0.1 1.8 2 0 0 2 2 1 1 TMEM154 protein family EVC2_like PF12297.8 PIK39592.1 - 0.04 12.6 0.2 0.058 12.1 0.2 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein C2-set PF05790.15 PIK39592.1 - 0.04 14.1 0.0 6.2 7.1 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 PIK39592.1 - 0.054 13.6 0.1 18 5.4 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain SieB PF14163.6 PIK39592.1 - 0.087 12.3 0.4 0.17 11.4 0.4 1.5 1 0 0 1 1 1 0 Super-infection exclusion protein B Syndecan PF01034.20 PIK39592.1 - 0.1 12.5 0.2 0.27 11.2 0.2 1.7 1 0 0 1 1 1 0 Syndecan domain DUF1772 PF08592.11 PIK39592.1 - 0.12 12.7 0.0 0.58 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) TMEM132D_C PF15706.5 PIK39592.1 - 0.13 12.0 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4083 PF13314.6 PIK39592.1 - 0.3 11.0 3.0 0.6 10.1 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) RT_RNaseH PF17917.1 PIK39593.1 - 1.8e-10 41.0 0.0 3.6e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK39593.1 - 0.019 15.1 0.3 0.033 14.3 0.3 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain Pkinase PF00069.25 PIK39594.1 - 1.9e-53 181.5 0.0 2.2e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39594.1 - 6.4e-34 117.4 0.0 7.5e-34 117.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK39594.1 - 7.8e-07 28.4 0.1 8.7e-07 28.2 0.1 1.0 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK39594.1 - 3e-06 26.7 0.5 4.6e-06 26.1 0.5 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK39594.1 - 8e-05 22.3 0.5 0.0001 21.9 0.5 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK39594.1 - 0.0071 16.3 0.2 0.014 15.3 0.2 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK39594.1 - 0.0088 15.6 1.4 0.015 14.9 1.4 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase dCache_1 PF02743.18 PIK39594.1 - 0.011 15.6 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 0 Cache domain Kinase-like PF14531.6 PIK39594.1 - 0.028 13.7 0.0 0.052 12.9 0.0 1.5 1 1 0 1 1 1 0 Kinase-like UBD PF16455.5 PIK39594.1 - 0.053 13.8 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-binding domain Glycos_transf_N PF04413.16 PIK39594.1 - 0.071 12.8 0.1 0.095 12.3 0.1 1.1 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Translin PF01997.16 PIK39595.1 - 7e-55 186.2 0.0 8.4e-55 185.9 0.0 1.1 1 0 0 1 1 1 1 Translin family bZIP_2 PF07716.15 PIK39596.1 - 6.8e-14 51.7 11.3 6.8e-14 51.7 11.3 1.9 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK39596.1 - 5.6e-05 23.1 6.0 5.6e-05 23.1 6.0 2.2 2 0 0 2 2 2 1 bZIP transcription factor XkdW PF09636.10 PIK39596.1 - 0.16 12.1 0.9 0.29 11.3 0.9 1.3 1 0 0 1 1 1 0 XkdW protein Cas_Csy4 PF09618.10 PIK39596.1 - 0.52 10.4 3.8 0.98 9.5 3.8 1.5 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) bZIP_Maf PF03131.17 PIK39596.1 - 3.4 8.2 11.4 0.27 11.8 5.2 2.0 1 1 1 2 2 2 0 bZIP Maf transcription factor RCDG1 PF15725.5 PIK39596.1 - 4.7 7.7 12.9 3.9 8.0 1.5 2.6 2 1 0 2 2 2 0 Renal cancer differentiation gene 1 protein Alpha-amylase PF00128.24 PIK39597.1 - 2.1e-31 109.8 0.0 2.7e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.5 PIK39597.1 - 4.1e-17 61.5 0.5 6.7e-17 60.8 0.5 1.3 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Glyco_hydro_70 PF02324.16 PIK39597.1 - 0.13 10.5 0.0 0.16 10.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 Alpha-amylase PF00128.24 PIK39598.1 - 4.8e-27 95.4 0.0 1.1e-26 94.2 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 PIK39598.1 - 0.0016 18.5 0.0 0.0043 17.2 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Lig_chan-Glu_bd PF10613.9 PIK39599.1 - 3.1e-14 53.2 0.0 5.8e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 PIK39599.1 - 1.6e-12 47.5 0.0 1.4e-10 41.2 0.0 2.2 1 1 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK39599.1 - 4.4e-11 42.6 0.0 3.5e-10 39.7 0.0 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF4282 PF14110.6 PIK39599.1 - 0.026 15.2 3.8 4.6 8.0 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4282) Lig_chan PF00060.26 PIK39600.1 - 1.3e-21 77.0 0.2 2e-21 76.4 0.2 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK39600.1 - 3.4e-21 75.6 0.0 6.3e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 PIK39600.1 - 5.5e-10 39.1 0.0 1.2e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 PIK39600.1 - 0.0068 15.6 0.0 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region zf-CHC2 PF01807.20 PIK39600.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 CHC2 zinc finger CRT-like PF08627.10 PIK39601.1 - 3e-07 29.7 4.6 3e-07 29.7 4.6 2.2 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 PIK39601.1 - 5.3e-07 29.4 4.7 5.3e-07 29.4 4.7 1.9 1 1 1 2 2 2 1 Solute carrier family 35 Nuc_sug_transp PF04142.15 PIK39601.1 - 5.1e-06 25.9 0.9 7.9e-06 25.3 0.9 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 PIK39601.1 - 2.9e-05 23.4 1.7 2.9e-05 23.4 1.7 1.7 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 PIK39601.1 - 5.3e-05 23.4 5.6 5.3e-05 23.4 5.6 3.0 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 PIK39601.1 - 0.0003 20.3 4.5 0.00039 19.9 4.5 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family AGTRAP PF06396.11 PIK39601.1 - 0.27 11.0 3.1 0.16 11.8 0.7 1.8 2 0 0 2 2 2 0 Angiotensin II, type I receptor-associated protein (AGTRAP) TMEM234 PF10639.9 PIK39601.1 - 2.4 8.2 7.6 0.39 10.8 1.9 2.4 3 0 0 3 3 3 0 Putative transmembrane family 234 PSI_PSAK PF01241.18 PIK39602.1 - 0.05 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 Photosystem I psaG / psaK Acetyltransf_4 PF13420.7 PIK39602.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RVT_1 PF00078.27 PIK39603.1 - 1.8e-30 106.1 0.0 3.2e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK39603.1 - 4.5e-14 52.3 0.0 9.2e-14 51.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PHD PF00628.29 PIK39603.1 - 6.6e-07 29.1 10.5 8.7e-07 28.7 8.9 2.2 2 1 0 2 2 2 1 PHD-finger RT_RNaseH PF17917.1 PIK39603.1 - 0.0027 18.0 0.0 0.0053 17.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Asp_protease PF09668.10 PIK39603.1 - 0.068 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Cyt-b5 PF00173.28 PIK39604.1 - 5.3e-22 77.8 0.0 1e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 PIK39604.1 - 1.4e-15 57.9 0.0 3.2e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 PIK39604.1 - 4.4e-12 46.2 0.1 3.4e-11 43.4 0.1 2.4 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain CS PF04969.16 PIK39604.1 - 6.9e-05 23.8 0.1 0.00016 22.6 0.1 1.6 1 0 0 1 1 1 1 CS domain NAD_binding_6 PF08030.12 PIK39604.1 - 0.00014 22.0 0.0 0.00032 20.8 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ank_2 PF12796.7 PIK39605.1 - 3.3e-27 94.9 1.6 4.8e-14 52.7 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK39605.1 - 2.1e-13 50.2 0.2 4.6e-07 30.0 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK39605.1 - 8.8e-13 48.5 0.0 1.5e-06 28.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Chromo PF00385.24 PIK39605.1 - 9.1e-10 38.3 0.0 2.5e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ank PF00023.30 PIK39605.1 - 7.8e-09 35.6 1.3 0.017 15.6 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 PIK39605.1 - 1.6e-07 31.0 0.1 0.11 13.2 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat RhoGAP PF00620.27 PIK39606.1 - 4e-29 101.4 0.0 8.3e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 PIK39606.1 - 7.6e-14 51.3 7.0 1.8e-13 50.2 7.0 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 PIK39606.1 - 6.8e-13 48.5 0.0 1.8e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 SH2 domain DUF2318 PF10080.9 PIK39606.1 - 0.0072 16.4 1.0 0.014 15.5 1.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) zf-RING_9 PF13901.6 PIK39606.1 - 0.047 13.7 1.0 0.14 12.1 1.0 1.8 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon C1_2 PF03107.16 PIK39606.1 - 0.11 12.8 4.6 0.45 10.9 4.6 2.2 1 1 0 1 1 1 0 C1 domain PHD PF00628.29 PIK39606.1 - 0.37 10.7 5.0 0.83 9.6 5.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 PIK39606.1 - 0.62 10.4 5.6 1.6 9.1 4.9 2.1 2 0 0 2 2 2 0 RING-like domain MFS_1 PF07690.16 PIK39607.1 - 5.8e-05 22.2 1.1 6.4e-05 22.0 1.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39607.1 - 0.00081 18.4 0.2 0.001 18.0 0.1 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK39609.1 - 2.5e-17 62.8 10.4 3.4e-17 62.4 10.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39609.1 - 5.1e-15 55.3 14.6 2.5e-14 53.0 14.6 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter Peptidase_M48_N PF16491.5 PIK39609.1 - 0.25 11.2 4.9 0.68 9.8 2.1 2.6 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices DUF5383 PF17355.2 PIK39609.1 - 4.7 7.6 5.7 0.38 11.1 0.4 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5383) FYRC PF05965.14 PIK39610.1 - 1.3e-24 86.2 0.0 5e-24 84.3 0.0 2.1 2 0 0 2 2 2 1 F/Y rich C-terminus FYRN PF05964.14 PIK39610.1 - 1.1e-20 73.2 0.5 1.1e-20 73.2 0.5 2.1 2 0 0 2 2 2 1 F/Y-rich N-terminus SET PF00856.28 PIK39610.1 - 4e-19 69.6 1.0 2e-18 67.3 0.5 2.4 2 1 0 2 2 2 1 SET domain zf-HC5HC2H_2 PF13832.6 PIK39610.1 - 4.5e-06 26.8 8.6 1.3e-05 25.3 8.6 1.8 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 PIK39610.1 - 0.00054 20.2 11.8 0.00054 20.2 11.8 2.6 2 1 0 2 2 2 1 PHD-like zinc-binding domain SRP-alpha_N PF04086.13 PIK39611.1 - 0.18 11.7 26.1 0.86 9.5 6.1 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF3198 PF11433.8 PIK39612.1 - 0.086 12.7 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) Spectrin PF00435.21 PIK39612.1 - 0.11 13.0 3.1 0.16 12.5 3.1 1.2 1 0 0 1 1 1 0 Spectrin repeat PHD PF00628.29 PIK39616.1 - 6.5e-44 147.6 96.0 2.7e-10 40.0 3.8 8.2 5 2 2 7 7 7 6 PHD-finger zf-HC5HC2H PF13771.6 PIK39616.1 - 2.6e-09 37.2 6.8 2.6e-09 37.2 6.8 7.8 4 3 3 7 7 7 3 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 PIK39616.1 - 1.1e-05 25.6 6.8 1.1e-05 25.6 6.8 7.3 2 2 4 7 7 7 3 PHD-zinc-finger like domain zf-RING_2 PF13639.6 PIK39616.1 - 0.00046 20.5 6.0 0.00046 20.5 6.0 9.4 7 3 3 10 10 10 3 Ring finger domain EF-hand_1 PF00036.32 PIK39617.1 - 1.9e-13 48.9 2.2 8.8e-06 24.9 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK39617.1 - 8.4e-13 47.1 3.5 2.8e-05 23.7 0.3 3.6 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 PIK39617.1 - 3.8e-12 46.5 1.9 3.5e-06 27.4 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK39617.1 - 2.5e-06 26.7 1.5 0.0012 18.3 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK39617.1 - 1.1e-05 25.2 5.7 0.013 15.3 0.1 3.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 PIK39617.1 - 3.9e-05 23.9 0.1 0.015 15.6 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 PIK39617.1 - 0.016 15.5 0.2 2.4 8.6 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain DUF3349 PF11829.8 PIK39617.1 - 0.069 13.9 0.1 7.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) DUF4924 PF16271.5 PIK39617.1 - 0.14 12.2 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) RPN13_C PF16550.5 PIK39617.1 - 0.15 12.3 0.0 12 6.1 0.0 2.6 2 1 0 2 2 2 0 UCH-binding domain LEA_1 PF03760.15 PIK39618.1 - 0.12 13.0 10.2 0.2 12.3 10.2 1.3 1 0 0 1 1 1 0 Late embryogenesis abundant (LEA) group 1 Mo-nitro_C PF06967.11 PIK39618.1 - 0.14 12.2 0.0 8.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Mo-dependent nitrogenase C-terminus AAA PF00004.29 PIK39619.1 - 7.7e-05 23.1 0.0 0.00026 21.4 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.27 PIK39619.1 - 0.00088 18.9 0.8 0.0019 17.8 0.8 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF815 PF05673.13 PIK39619.1 - 0.014 14.6 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_16 PF13191.6 PIK39619.1 - 0.014 15.8 0.0 0.06 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain PCI PF01399.27 PIK39620.1 - 3.8e-09 37.0 0.1 2.1e-08 34.6 0.0 2.3 2 0 0 2 2 2 1 PCI domain Ion_trans PF00520.31 PIK39622.1 - 1.3e-119 397.9 39.4 4.1e-64 216.1 15.0 2.0 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 PIK39622.1 - 2e-15 56.4 38.0 4.8e-09 35.4 2.4 5.5 4 2 1 5 5 5 5 Polycystin cation channel Ion_trans PF00520.31 PIK39623.1 - 1.3e-69 234.2 22.4 5.3e-51 173.2 17.2 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 PIK39623.1 - 0.0027 16.5 8.1 0.0027 16.5 8.1 2.3 1 1 1 2 2 2 2 Polycystin cation channel DUF3935 PF13071.6 PIK39623.1 - 0.25 11.9 5.0 2 9.0 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3935) PHR PF08005.12 PIK39624.1 - 4.7e-45 154.0 0.8 6.3e-45 153.5 0.8 1.2 1 0 0 1 1 1 1 PHR domain Glyco_hydro_79n PF03662.14 PIK39624.1 - 0.04 12.9 0.0 0.045 12.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain BTB PF00651.31 PIK39625.1 - 3.4e-25 88.4 0.3 7.9e-25 87.2 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK39625.1 - 5.3e-08 32.9 3.0 3.3e-07 30.3 1.3 2.2 1 1 0 2 2 2 1 BTB And C-terminal Kelch PriCT_1 PF08708.11 PIK39625.1 - 0.2 11.4 1.4 23 4.8 0.1 3.2 3 0 0 3 3 3 0 Primase C terminal 1 (PriCT-1) TFIIB PF00382.19 PIK39626.1 - 0.018 15.0 0.1 0.035 14.2 0.1 1.4 1 0 0 1 1 1 0 Transcription factor TFIIB repeat BRF1 PF07741.13 PIK39627.1 - 1.3e-23 83.2 17.1 2e-23 82.7 17.1 1.3 1 0 0 1 1 1 1 Brf1-like TBP-binding domain DUF1387 PF07139.11 PIK39627.1 - 0.0072 16.1 9.4 0.01 15.6 9.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) CAS_C PF12026.8 PIK39627.1 - 0.19 11.8 5.5 0.29 11.2 5.5 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Neur_chan_memb PF02932.16 PIK39627.1 - 0.48 10.4 2.1 0.6 10.1 2.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 PIK39627.1 - 5 5.8 5.1 4.8 5.8 5.1 1.1 1 0 0 1 1 1 0 Presenilin Hepatitis_core PF00906.20 PIK39628.1 - 0.026 14.1 0.7 0.028 14.0 0.4 1.3 1 1 0 1 1 1 0 Hepatitis core antigen Menin PF05053.13 PIK39629.1 - 0.071 11.5 5.4 0.079 11.3 5.4 1.2 1 0 0 1 1 1 0 Menin Adenylsucc_synt PF00709.21 PIK39630.1 - 6.7e-89 298.7 0.1 7.6e-89 298.5 0.1 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase MLANA PF14991.6 PIK39633.1 - 0.0056 17.0 0.7 0.096 13.0 0.2 2.1 1 1 1 2 2 2 2 Protein melan-A Rax2 PF12768.7 PIK39633.1 - 0.24 10.8 0.4 0.36 10.3 0.4 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity CUB PF00431.20 PIK39634.1 - 7.4e-09 35.9 0.0 1.1e-07 32.2 0.0 2.7 1 1 0 1 1 1 1 CUB domain Phage_tail_3 PF08813.11 PIK39634.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage tail tube protein, TTP PDCD9 PF07147.12 PIK39635.1 - 2.5e-61 208.3 0.4 1.7e-38 133.0 0.1 2.0 1 1 1 2 2 2 2 Mitochondrial 28S ribosomal protein S30 (PDCD9) GalKase_gal_bdg PF10509.9 PIK39636.1 - 3.6e-23 80.9 0.0 6.4e-23 80.1 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 PIK39636.1 - 5.3e-11 42.7 0.0 1.2e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 PIK39636.1 - 3.8e-05 23.8 2.2 0.005 17.0 2.2 2.6 1 1 0 1 1 1 1 GHMP kinases N terminal domain DUF829 PF05705.14 PIK39637.1 - 1.1e-28 100.8 0.2 1.9e-28 100.0 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF659 PF04937.15 PIK39637.1 - 0.055 13.3 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Glutaredoxin PF00462.24 PIK39638.1 - 6.5e-09 35.9 0.0 9.5e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 PIK39638.1 - 0.00052 20.4 0.0 0.00063 20.1 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 PIK39638.1 - 0.0078 16.7 0.0 0.0094 16.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain IF3_N PF05198.16 PIK39638.1 - 0.042 14.1 0.0 0.054 13.8 0.0 1.2 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain DSBA PF01323.20 PIK39638.1 - 0.049 13.4 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Molydop_binding PF01568.21 PIK39638.1 - 0.058 13.4 0.0 0.067 13.2 0.0 1.0 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Asp_decarbox PF02261.16 PIK39638.1 - 0.16 11.9 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 Aspartate decarboxylase rve PF00665.26 PIK39639.1 - 2.3e-13 50.4 0.0 3.4e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF5641 PF18701.1 PIK39639.1 - 0.00033 20.7 0.2 0.00064 19.8 0.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve_3 PF13683.6 PIK39639.1 - 0.001 18.8 0.0 0.0022 17.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain NCU-G1 PF15065.6 PIK39640.1 - 1.8e-25 89.7 0.8 2.2e-25 89.4 0.8 1.1 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 DUF4384 PF14326.6 PIK39640.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) NCU-G1 PF15065.6 PIK39641.1 - 2.5e-53 181.3 0.0 3.4e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 MBDa PF16564.5 PIK39642.1 - 2.5e-27 94.8 0.7 4.4e-27 94.1 0.7 1.4 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.19 PIK39642.1 - 8.7e-26 89.4 0.6 1.1e-20 73.1 0.0 2.3 1 1 1 2 2 2 2 Methyl-CpG binding domain MBD_C PF14048.6 PIK39642.1 - 2.4e-08 34.5 0.0 5.4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 Condensin2nSMC PF12422.8 PIK39643.1 - 1.3e-36 126.0 0.0 3.5e-36 124.6 0.0 1.7 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 PIK39643.1 - 6e-09 35.4 0.5 0.015 15.5 0.1 3.9 3 0 0 3 3 3 3 HEAT repeat Cnd1 PF12717.7 PIK39643.1 - 0.00013 22.1 0.1 0.0011 19.0 0.1 2.3 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK39643.1 - 0.0005 20.4 0.1 0.064 13.7 0.1 2.9 1 1 3 4 4 4 2 HEAT repeats Adaptin_N PF01602.20 PIK39643.1 - 0.001 17.7 0.2 0.0028 16.3 0.2 1.6 1 1 1 2 2 2 1 Adaptin N terminal region CLASP_N PF12348.8 PIK39643.1 - 0.036 13.6 0.0 1.6 8.2 0.0 2.4 1 1 1 2 2 2 0 CLASP N terminal HEAT_EZ PF13513.6 PIK39643.1 - 0.052 14.1 0.5 0.27 11.8 0.2 2.4 2 1 0 2 2 2 0 HEAT-like repeat Pet127 PF08634.10 PIK39644.1 - 0.052 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial protein Pet127 Phage_int_SAM_4 PF13495.6 PIK39645.1 - 1.8e-06 28.3 0.0 2.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK39645.1 - 0.0017 18.6 0.8 0.0056 16.9 0.0 2.2 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 PIK39646.1 - 8e-19 68.0 0.1 2.3e-18 66.5 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MULE PF10551.9 PIK39647.1 - 2e-07 31.3 0.0 4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 PIK39647.1 - 9.7e-05 21.4 0.0 0.00014 20.9 0.0 1.5 1 1 0 1 1 1 1 Transposase, Mutator family DDE_Tnp_ISL3 PF01610.17 PIK39647.1 - 0.022 14.5 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Transposase LexA_DNA_bind PF01726.16 PIK39647.1 - 0.055 13.3 0.0 7.3 6.4 0.0 2.8 3 0 0 3 3 3 0 LexA DNA binding domain PPP1R26_N PF15740.5 PIK39648.1 - 0.0025 16.6 0.9 0.0028 16.4 0.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus Exo_endo_phos PF03372.23 PIK39651.1 - 1.9e-11 43.9 0.1 3.4e-11 43.1 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK39651.1 - 2.9e-08 33.6 0.0 2e-07 30.8 0.0 2.3 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Chal_sti_synt_N PF00195.19 PIK39651.1 - 0.16 11.4 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain F-box PF00646.33 PIK39652.1 - 0.17 11.8 0.8 0.4 10.6 0.2 1.9 2 0 0 2 2 2 0 F-box domain THAP PF05485.12 PIK39653.1 - 2.4e-15 57.2 0.3 6.8e-15 55.8 0.0 2.0 2 0 0 2 2 2 1 THAP domain Tnp_P_element PF12017.8 PIK39653.1 - 1.8e-14 53.7 0.0 2.9e-14 53.0 0.0 1.4 1 1 0 1 1 1 1 Transposase protein DUF16 PF01519.16 PIK39653.1 - 0.052 14.0 0.7 0.1 13.1 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF4404 PF14357.6 PIK39654.1 - 0.031 14.9 0.7 0.095 13.4 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) EamA PF00892.20 PIK39655.1 - 5.7e-31 107.5 29.1 1e-19 71.1 4.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK39655.1 - 1e-07 31.6 19.3 3.9e-07 29.7 19.3 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family DUF4834 PF16118.5 PIK39655.1 - 0.014 16.3 1.0 0.037 15.0 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 PIK39655.1 - 0.028 14.8 4.4 0.073 13.5 4.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF1003 PF06210.11 PIK39655.1 - 0.038 14.1 4.4 0.14 12.3 4.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1003) TMEM51 PF15345.6 PIK39655.1 - 0.085 12.7 0.9 0.13 12.1 0.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Spt20 PF12090.8 PIK39655.1 - 0.089 12.4 6.7 0.12 12.0 6.7 1.1 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 PIK39655.1 - 1.8 8.7 13.0 3 8.0 13.0 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Androgen_recep PF02166.16 PIK39655.1 - 9.7 4.9 8.0 12 4.6 8.0 1.1 1 0 0 1 1 1 0 Androgen receptor EamA PF00892.20 PIK39656.1 - 1.5e-31 109.3 27.1 3.2e-20 72.7 3.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK39656.1 - 5.6e-08 32.5 18.7 2.8e-07 30.2 18.7 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family DUF4834 PF16118.5 PIK39656.1 - 0.02 15.8 0.5 0.053 14.5 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF1003 PF06210.11 PIK39656.1 - 0.021 14.9 0.4 0.053 13.6 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Spt20 PF12090.8 PIK39656.1 - 0.037 13.6 4.0 0.054 13.1 4.0 1.1 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 PIK39656.1 - 1.6 7.5 5.0 2.1 7.1 5.0 1.1 1 0 0 1 1 1 0 Androgen receptor SUIM_assoc PF16619.5 PIK39656.1 - 7.2 6.8 14.0 13 6.0 14.0 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Cmc1 PF08583.10 PIK39657.1 - 1.4e-19 69.8 6.6 2.1e-19 69.3 6.6 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 PIK39657.1 - 0.0033 17.5 3.0 2 8.7 0.1 2.7 2 0 0 2 2 2 2 CHCH domain Tox-MPTase4 PF15640.6 PIK39657.1 - 0.067 13.1 0.3 0.18 11.7 0.3 1.7 1 1 0 1 1 1 0 Metallopeptidase toxin 4 MNNL PF07657.13 PIK39657.1 - 0.16 12.1 5.2 0.32 11.1 5.1 1.6 1 1 0 1 1 1 0 N terminus of Notch ligand MTCP1 PF08991.10 PIK39657.1 - 0.28 11.4 4.9 1.5 9.1 0.4 2.3 2 0 0 2 2 2 0 Mature-T-Cell Proliferation I type DUF3128 PF11326.8 PIK39657.1 - 5.2 7.5 8.3 34 4.9 8.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Pet191_N PF10203.9 PIK39657.1 - 7.3 7.0 11.8 13 6.2 1.0 3.0 1 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 zf-H2C2_2 PF13465.6 PIK39658.1 - 1.3e-29 101.2 83.4 4.8e-07 29.9 1.3 11.7 11 1 1 12 12 12 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39658.1 - 2.3e-17 62.4 85.9 0.00019 21.7 1.7 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK39658.1 - 4.8e-12 45.4 89.8 1.9e-07 30.7 1.4 10.0 11 0 0 11 11 11 6 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 PIK39658.1 - 1.8e-09 37.6 78.3 0.041 14.7 1.2 10.4 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39658.1 - 0.056 13.7 0.1 0.056 13.7 0.1 7.8 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding Sulfotransfer_2 PF03567.14 PIK39659.1 - 5.3e-47 160.9 2.8 6.8e-47 160.5 2.8 1.1 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_M60 PF13402.6 PIK39659.1 - 0.0092 15.5 1.7 0.063 12.8 0.0 2.1 1 1 1 2 2 2 1 Peptidase M60, enhancin and enhancin-like Sulfotransfer_2 PF03567.14 PIK39660.1 - 5.3e-43 147.7 1.4 5.3e-43 147.7 1.4 1.5 2 0 0 2 2 2 1 Sulfotransferase family DUF3659 PF12396.8 PIK39660.1 - 0.12 12.3 0.8 0.43 10.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) SR-25 PF10500.9 PIK39660.1 - 0.51 9.9 7.0 0.91 9.1 7.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LysM PF01476.20 PIK39661.1 - 2.2e-09 37.2 0.0 4.1e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 LysM domain TLD PF07534.16 PIK39662.1 - 3.1e-36 124.7 0.1 4.2e-36 124.2 0.1 1.2 1 0 0 1 1 1 1 TLD zinc_ribbon_9 PF14369.6 PIK39663.1 - 0.39 11.0 2.7 7.3 7.0 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon DivIC PF04977.15 PIK39664.1 - 0.042 13.6 9.0 1.1 9.1 0.3 2.9 2 1 0 2 2 2 0 Septum formation initiator Lectin_C PF00059.21 PIK39665.1 - 5.2e-15 56.1 5.3 8.1e-15 55.5 5.3 1.3 1 0 0 1 1 1 1 Lectin C-type domain Calx-beta PF03160.14 PIK39665.1 - 7.4e-05 22.9 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 Calx-beta domain UL45 PF05473.12 PIK39665.1 - 0.0012 18.5 0.8 0.0017 18.0 0.8 1.3 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.12 PIK39665.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein UvrD_C PF13361.6 PIK39666.1 - 2.8e-13 50.0 0.1 1.3e-12 47.8 0.0 1.5 1 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 PIK39666.1 - 2.3e-10 40.1 0.2 1.4e-08 34.4 0.0 2.9 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 PIK39666.1 - 7.4e-09 35.6 0.5 1.2e-08 34.9 0.1 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 PIK39666.1 - 2.2e-08 34.1 0.5 0.00038 20.3 0.0 2.7 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 PIK39666.1 - 1.6e-07 31.8 0.1 4.8e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF4428 PF14471.6 PIK39666.1 - 0.023 14.6 0.1 3.1 7.8 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) Peptidase_C37 PF05416.12 PIK39666.1 - 0.043 12.3 0.0 0.069 11.7 0.0 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase zf-CCHC PF00098.23 PIK39667.1 - 5e-05 23.2 20.5 0.00076 19.4 3.9 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK39667.1 - 0.022 14.6 4.5 0.022 14.6 4.5 3.8 2 2 1 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK39667.1 - 1.3 8.9 19.1 0.16 11.8 1.9 3.3 1 1 2 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK39667.1 - 6.4 6.6 13.9 4.6 7.1 3.1 2.4 1 1 1 2 2 2 0 C2H2 zinc-finger Hemopexin PF00045.19 PIK39668.1 - 6.7e-54 179.6 18.3 1.3e-18 66.7 0.4 4.1 4 0 0 4 4 4 4 Hemopexin PetN PF03742.14 PIK39668.1 - 0.16 11.9 0.8 0.28 11.1 0.8 1.4 1 0 0 1 1 1 0 PetN DUF4993 PF16384.5 PIK39668.1 - 0.2 10.6 2.4 3.1 6.7 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function zf-C3HC4 PF00097.25 PIK39669.1 - 8.3e-06 25.6 15.4 8.3e-06 25.6 15.4 3.7 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK39669.1 - 8.4e-06 25.7 9.2 8.4e-06 25.7 9.2 3.2 3 2 1 4 4 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK39669.1 - 4.6e-05 23.2 15.7 4.6e-05 23.2 15.7 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK39669.1 - 6.6e-05 23.0 10.0 6.6e-05 23.0 10.0 4.9 4 1 0 4 4 2 2 B-box zinc finger zf-RING_2 PF13639.6 PIK39669.1 - 0.0003 21.0 17.5 0.0003 21.0 17.5 3.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK39669.1 - 0.00034 20.4 15.9 0.00034 20.4 15.9 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK39669.1 - 0.0083 16.3 14.3 0.0083 16.3 14.3 3.9 3 2 1 4 4 3 1 zinc finger of C3HC4-type, RING Mst1_SARAH PF11629.8 PIK39669.1 - 0.15 12.2 3.9 0.13 12.4 0.9 2.3 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Baculo_PEP_C PF04513.12 PIK39669.1 - 0.62 10.1 8.0 0.91 9.6 1.3 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Borrelia_P83 PF05262.11 PIK39669.1 - 1 7.8 28.1 1.5 7.2 28.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein HIP1_clath_bdg PF16515.5 PIK39669.1 - 2.3 8.9 29.3 0.051 14.2 7.1 3.7 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3584 PF12128.8 PIK39670.1 - 3.9 4.9 18.7 5.4 4.4 18.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Lectin_N PF03954.14 PIK39670.1 - 5.3 6.8 7.5 1.6 8.5 0.4 2.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain zf-C3HC4 PF00097.25 PIK39672.1 - 3.3e-07 30.1 13.1 3.3e-07 30.1 13.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK39672.1 - 6.4e-07 29.3 8.7 6.7e-07 29.2 6.8 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK39672.1 - 9.5e-06 25.4 11.8 9.5e-06 25.4 11.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK39672.1 - 0.00014 22.1 15.9 0.00014 22.1 15.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK39672.1 - 0.0002 21.2 12.8 0.0002 21.2 12.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK39672.1 - 0.0006 19.6 13.7 0.0006 19.6 13.7 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK39672.1 - 0.0031 17.6 12.4 0.0031 17.6 12.4 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING Tma16 PF11176.8 PIK39673.1 - 3.3e-37 127.6 7.0 4.4e-37 127.2 7.0 1.2 1 0 0 1 1 1 1 Translation machinery-associated protein 16 RVT_1 PF00078.27 PIK39674.1 - 1.3e-07 31.4 0.1 2.3e-07 30.6 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Vitellogenin_N PF01347.22 PIK39675.1 - 1.1e-31 110.0 0.1 1.5e-31 109.5 0.1 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region Rsd_AlgQ PF04353.13 PIK39675.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF1943 PF09172.11 PIK39676.1 - 1.6e-49 168.9 0.1 7.3e-49 166.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.22 PIK39676.1 - 4.4e-25 88.1 1.4 8.7e-25 87.2 1.4 1.5 1 0 0 1 1 1 1 Lipoprotein amino terminal region VWD PF00094.25 PIK39676.1 - 5.9e-19 68.9 0.4 5.9e-19 68.9 0.4 4.8 4 1 0 4 4 4 1 von Willebrand factor type D domain C8 PF08742.11 PIK39676.1 - 7.9e-09 35.8 2.3 1.8e-08 34.7 2.3 1.7 1 0 0 1 1 1 1 C8 domain Apolipoprotein PF01442.18 PIK39676.1 - 0.00077 19.4 1.8 0.002 18.0 1.8 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain HEAT_2 PF13646.6 PIK39676.1 - 0.015 15.6 0.0 0.039 14.4 0.0 1.6 1 0 0 1 1 1 0 HEAT repeats RHD_dimer PF16179.5 PIK39676.1 - 0.021 14.8 0.0 0.096 12.7 0.0 2.1 1 0 0 1 1 1 0 Rel homology dimerisation domain bZIP_2 PF07716.15 PIK39677.1 - 5.3e-10 39.2 2.8 5.3e-10 39.2 2.8 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK39677.1 - 4.6e-05 23.4 1.0 0.00015 21.8 1.0 1.8 1 0 0 1 1 1 1 bZIP transcription factor fn3 PF00041.21 PIK39678.1 - 2.6e-10 40.5 0.1 2.5e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Y_phosphatase PF00102.27 PIK39679.1 - 2e-18 66.8 0.1 2.2e-18 66.7 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Helo_like_N PF17111.5 PIK39679.1 - 0.076 12.4 0.1 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins MIF PF01187.18 PIK39680.1 - 0.038 14.3 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) Sigma54_AID PF00309.20 PIK39682.1 - 0.086 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) NACHT PF05729.12 PIK39682.1 - 0.09 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Death PF00531.22 PIK39683.1 - 2e-15 56.7 0.7 3.1e-15 56.1 0.7 1.3 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK39684.1 - 2.1e-10 40.8 0.1 3.9e-10 39.9 0.1 1.4 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK39685.1 - 7e-06 26.3 0.3 0.053 13.8 0.1 2.7 3 0 0 3 3 3 2 Death effector domain BORA_N PF15280.6 PIK39685.1 - 0.07 12.8 0.0 0.25 11.0 0.0 1.9 1 1 1 2 2 2 0 Protein aurora borealis N-terminus CHASE9 PF17153.4 PIK39685.1 - 0.086 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Periplasmic sensor domain, extracellular rve PF00665.26 PIK39686.1 - 3.1e-19 69.3 0.0 8.6e-19 67.9 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK39686.1 - 0.0014 18.4 0.1 0.0034 17.1 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK39687.1 - 4.6e-29 100.8 0.0 1.2e-28 99.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK39687.1 - 9.8e-27 92.9 0.1 2.9e-26 91.4 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39687.1 - 3.1e-17 62.9 0.1 6.7e-17 61.8 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK39687.1 - 0.0068 16.9 0.0 0.02 15.4 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK39687.1 - 0.028 15.1 0.0 0.07 13.8 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RRM_3 PF08777.11 PIK39687.1 - 0.077 13.0 0.2 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif ADD_DNMT3 PF17980.1 PIK39687.1 - 0.25 11.4 2.6 0.63 10.1 2.6 1.6 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 Phasin PF05597.11 PIK39688.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) cNMP_binding PF00027.29 PIK39689.1 - 2.9e-09 36.9 0.0 3.9e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF5449 PF17528.2 PIK39689.1 - 0.09 12.5 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5449) cNMP_binding PF00027.29 PIK39690.1 - 5.4e-21 74.5 0.0 6.9e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ornatin PF02088.15 PIK39690.1 - 0.071 12.9 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Ornatin CUB PF00431.20 PIK39691.1 - 4.5e-08 33.4 0.0 1.2e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 CUB domain Synuclein PF01387.17 PIK39691.1 - 0.059 13.6 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 Synuclein Trypsin PF00089.26 PIK39692.1 - 8.4e-24 84.6 0.1 9.2e-24 84.5 0.1 1.0 1 0 0 1 1 1 1 Trypsin Ldl_recept_b PF00058.17 PIK39693.1 - 1.4e-51 172.7 25.5 7.8e-10 39.1 0.0 11.8 13 0 0 13 13 13 8 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK39693.1 - 6.5e-14 51.9 57.9 1.1e-08 35.2 6.3 4.6 5 0 0 5 5 4 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK39693.1 - 7e-09 35.6 1.4 0.0012 18.5 0.0 6.7 3 3 3 6 6 6 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 PIK39693.1 - 4.9e-06 26.6 0.0 7.1 6.9 0.0 6.2 6 2 2 8 8 8 1 Arylesterase I-set PF07679.16 PIK39693.1 - 2.5e-05 24.2 0.0 8.9e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK39693.1 - 0.00011 22.5 0.2 0.00047 20.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK39693.1 - 0.00017 22.1 1.3 0.00045 20.8 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain CUB PF00431.20 PIK39693.1 - 0.00033 21.0 0.0 0.00094 19.5 0.0 1.8 2 0 0 2 2 1 1 CUB domain ig PF00047.25 PIK39693.1 - 0.00077 19.6 0.0 0.002 18.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK39693.1 - 0.0039 16.7 0.0 0.01 15.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Invasin_D3 PF09134.10 PIK39693.1 - 0.0057 16.9 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 Invasin, domain 3 Ig_5 PF16681.5 PIK39693.1 - 0.046 14.1 0.1 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain GyrI-like PF06445.15 PIK39694.1 - 0.034 14.4 0.2 0.07 13.4 0.2 1.5 1 1 0 1 1 1 0 GyrI-like small molecule binding domain TSP_1 PF00090.19 PIK39695.1 - 1.9e-20 72.8 63.1 1.1e-11 44.8 7.2 6.2 7 1 0 7 7 7 4 Thrombospondin type 1 domain rve PF00665.26 PIK39696.1 - 3.2e-15 56.4 0.0 1.6e-14 54.1 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK39696.1 - 1.1e-08 35.1 2.4 1.3e-08 34.8 0.2 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain PHD PF00628.29 PIK39696.1 - 2.2e-06 27.4 15.4 2.2e-06 27.4 15.4 2.6 3 0 0 3 3 3 1 PHD-finger Peptidase_C48 PF02902.19 PIK39696.1 - 7.2e-06 26.0 0.0 2.1e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ER-remodelling PF14755.6 PIK39696.1 - 0.003 17.9 8.8 0.0069 16.7 8.8 1.6 1 0 0 1 1 1 1 Intracellular membrane remodeller Lipin_N PF04571.14 PIK39696.1 - 0.074 13.0 0.0 1.1 9.3 0.0 2.8 3 0 0 3 3 3 0 lipin, N-terminal conserved region Arch_flagellin PF01917.16 PIK39696.1 - 0.098 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Archaebacterial flagellin ANAPC4_WD40 PF12894.7 PIK39700.1 - 0.00077 19.7 0.0 0.25 11.6 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain RNase_H_2 PF13482.6 PIK39701.1 - 0.0095 15.9 0.0 0.058 13.4 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily RNase_T PF00929.24 PIK39701.1 - 0.028 15.0 0.0 1.8 9.1 0.0 2.6 2 1 0 2 2 2 0 Exonuclease Spectrin PF00435.21 PIK39702.1 - 7.7e-137 447.4 79.2 3.9e-28 98.0 2.8 7.9 8 0 0 8 8 8 7 Spectrin repeat Tetrabrachion PF11401.8 PIK39702.1 - 0.041 13.9 0.1 0.19 11.8 0.1 2.2 1 0 0 1 1 1 0 Tetrabrachion GvpG PF05120.12 PIK39702.1 - 0.15 12.1 0.2 0.15 12.1 0.2 4.3 4 1 1 5 5 5 0 Gas vesicle protein G OMS28_porin PF03532.13 PIK39702.1 - 0.9 8.7 5.9 0.1 11.8 0.6 2.1 2 1 0 2 2 2 0 OMS28 porin LPP PF04728.13 PIK39702.1 - 1.7 9.1 0.0 1.7 9.1 0.0 4.1 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Fe_dep_repr_C PF02742.15 PIK39702.1 - 3.6 7.7 9.9 45 4.2 0.1 5.4 5 1 1 6 6 6 0 Iron dependent repressor, metal binding and dimerisation domain DUF948 PF06103.11 PIK39702.1 - 6.4 7.1 15.1 8.4 6.7 0.1 5.0 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 PIK39703.1 - 2.5e-97 320.4 51.7 2.4e-25 89.0 7.6 6.0 6 0 0 6 6 6 6 Spectrin repeat SH3_1 PF00018.28 PIK39703.1 - 7.4e-15 54.3 0.0 1.8e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK39703.1 - 1.3e-10 40.9 0.0 2.5e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK39703.1 - 5.8e-08 32.3 0.0 1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain AKNA PF12443.8 PIK39703.1 - 0.031 14.9 0.5 0.031 14.9 0.5 4.7 5 1 0 6 6 5 0 AT-hook-containing transcription factor SH3_3 PF08239.11 PIK39703.1 - 0.087 13.1 0.0 0.27 11.5 0.0 1.9 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_10 PF17902.1 PIK39703.1 - 0.15 12.1 0.1 0.37 10.9 0.1 1.6 1 0 0 1 1 1 0 SH3 domain GlutR_dimer PF00745.20 PIK39703.1 - 0.83 10.1 5.5 3.5 8.1 0.0 3.9 3 1 1 4 4 4 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF713 PF05218.14 PIK39703.1 - 0.96 9.2 10.8 0.59 9.8 0.4 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF713) PMC2NT PF08066.12 PIK39703.1 - 1.5 9.6 16.3 0.18 12.5 0.7 4.5 4 1 2 6 6 6 0 PMC2NT (NUC016) domain Med10 PF09748.9 PIK39703.1 - 3.3 7.7 6.5 32 4.5 0.1 4.3 5 0 0 5 5 5 0 Transcription factor subunit Med10 of Mediator complex Snapin_Pallidin PF14712.6 PIK39703.1 - 3.9 8.0 27.4 0.54 10.7 0.2 6.4 5 2 3 8 8 8 0 Snapin/Pallidin Spectrin PF00435.21 PIK39704.1 - 4.5e-142 464.2 70.4 2.5e-24 85.8 0.1 8.3 7 1 1 8 8 8 8 Spectrin repeat EFhand_Ca_insen PF08726.10 PIK39704.1 - 2.2e-19 69.3 0.1 1.4e-18 66.8 0.0 2.5 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 PIK39704.1 - 2.6e-14 51.6 0.3 2.5e-07 29.8 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK39704.1 - 5.7e-11 41.4 0.1 1.4e-05 24.7 0.1 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 PIK39704.1 - 1.2e-10 41.7 2.4 4.4e-09 36.7 0.2 3.7 2 1 1 3 3 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK39704.1 - 2e-09 37.2 0.5 0.00027 20.7 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK39704.1 - 1.4e-08 33.9 0.0 0.0057 16.1 0.0 3.4 3 0 0 3 3 3 2 EF hand SCO1-SenC PF02630.14 PIK39704.1 - 0.0027 17.6 2.1 0.087 12.7 0.0 3.8 3 1 1 4 4 4 1 SCO1/SenC EF-hand_10 PF14788.6 PIK39704.1 - 0.096 12.6 1.1 0.25 11.2 0.3 2.2 2 0 0 2 2 1 0 EF hand HisKA_2 PF07568.12 PIK39704.1 - 0.32 11.1 2.3 6 7.0 0.1 4.0 2 1 1 3 3 3 0 Histidine kinase kleA_kleC PF17383.2 PIK39704.1 - 2.4 8.5 13.7 0.2 12.0 0.7 4.5 4 0 0 4 4 3 0 Uncharacterized KorC regulated protein A Erythro-docking PF09277.11 PIK39704.1 - 5.6 6.9 6.7 57 3.7 0.1 4.4 4 0 0 4 4 4 0 Erythronolide synthase, docking MBF2 PF15868.5 PIK39705.1 - 2.2e-15 56.9 0.0 3.9e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Transcription activator MBF2 Death PF00531.22 PIK39705.1 - 4.4e-08 33.2 0.0 6.9e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Death domain FtsL PF04999.13 PIK39706.1 - 0.14 12.1 0.6 0.29 11.1 0.0 1.8 2 0 0 2 2 2 0 Cell division protein FtsL Glyco_hydro_47 PF01532.20 PIK39707.1 - 1.2e-72 245.3 0.1 1.4e-72 245.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 YozE_SAM_like PF06855.12 PIK39707.1 - 0.12 12.5 1.2 25 5.1 0.0 3.2 3 0 0 3 3 3 0 YozE SAM-like fold Ank_2 PF12796.7 PIK39708.1 - 4.4e-38 129.8 1.4 1e-14 54.8 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK39708.1 - 2.6e-31 107.6 2.9 4.5e-08 33.5 0.0 6.5 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK39708.1 - 6.1e-30 99.9 0.4 0.016 15.7 0.0 8.3 8 0 0 8 8 8 8 Ankyrin repeat Ank_5 PF13857.6 PIK39708.1 - 2.4e-23 81.9 5.8 0.00015 22.0 0.0 6.4 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK39708.1 - 2.6e-20 71.9 5.4 0.0025 18.2 0.0 7.5 6 1 1 7 7 7 5 Ankyrin repeat Ribosomal_S6 PF01250.17 PIK39708.1 - 0.1 12.9 0.0 4.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S6 Neil1-DNA_bind PF09292.10 PIK39708.1 - 0.45 10.5 1.7 16 5.5 0.0 3.4 4 0 0 4 4 4 0 Endonuclease VIII-like 1, DNA bind Brix PF04427.18 PIK39709.1 - 1.1e-38 133.2 0.0 1.8e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 Brix domain Fam20C PF06702.12 PIK39710.1 - 2.3e-53 181.3 0.2 2.3e-53 181.3 0.2 1.8 2 0 0 2 2 2 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK39710.1 - 1.8e-05 23.8 0.3 6.3e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 FAM198 protein IgGFc_binding PF17517.2 PIK39711.1 - 7.3e-33 114.1 1.5 7.3e-33 114.1 1.5 2.0 1 1 1 2 2 2 1 IgGFc binding protein UCR_UQCRX_QCR9 PF05365.12 PIK39711.1 - 0.1 12.5 0.1 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Methyltransf_31 PF13847.6 PIK39713.1 - 8e-24 84.2 0.0 1.1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39713.1 - 2e-16 60.4 0.0 3.6e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39713.1 - 4.4e-16 59.4 0.0 7.4e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39713.1 - 3.1e-12 47.1 0.0 5.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39713.1 - 9e-09 35.4 0.0 1.4e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39713.1 - 5.8e-07 29.1 0.0 9.5e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 PIK39713.1 - 6.8e-07 28.8 0.0 1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 PIK39713.1 - 2.1e-06 27.3 0.0 6.3e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 PIK39713.1 - 3.5e-06 26.7 0.0 5.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Dimerisation2 PF16864.5 PIK39713.1 - 0.00098 19.1 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_32 PF13679.6 PIK39713.1 - 0.001 19.1 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK39713.1 - 0.0015 18.4 0.0 0.003 17.3 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 PIK39713.1 - 0.055 13.2 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) DOT1 PF08123.13 PIK39713.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 GCD14 PF08704.10 PIK39713.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Pox_MCEL PF03291.16 PIK39713.1 - 0.13 11.3 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme DUF746 PF05344.11 PIK39713.1 - 0.19 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) CHGN PF05679.16 PIK39714.1 - 1.1e-146 489.7 0.0 1.2e-146 489.6 0.0 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 PIK39714.1 - 2e-09 37.0 0.0 4.8e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK39714.1 - 0.00031 20.3 0.2 0.14 11.6 0.0 2.6 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Fringe PF02434.16 PIK39716.1 - 1.9e-17 63.5 0.0 3e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Fringe-like CHGN PF05679.16 PIK39716.1 - 1.1e-13 50.9 0.3 1.4e-13 50.5 0.3 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Galactosyl_T PF01762.21 PIK39716.1 - 0.0045 16.8 0.1 0.033 14.0 0.1 2.0 1 1 0 1 1 1 1 Galactosyltransferase Methyltransf_31 PF13847.6 PIK39717.1 - 5.2e-24 84.8 0.0 7.6e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39717.1 - 3.2e-16 59.8 0.0 6.3e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39717.1 - 6.7e-16 58.7 0.0 1.4e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39717.1 - 1.6e-12 48.0 0.0 2.6e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39717.1 - 2.7e-10 40.4 0.0 4.2e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39717.1 - 2.2e-08 33.7 0.0 4.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 PIK39717.1 - 4e-08 33.0 0.0 6.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK39717.1 - 1.9e-06 27.5 0.0 5.6e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 PIK39717.1 - 3.1e-06 26.6 0.0 5.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 PIK39717.1 - 0.00029 20.7 0.0 0.00071 19.4 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 PIK39717.1 - 0.0062 16.0 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 PIK39717.1 - 0.024 14.2 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 PIK39717.1 - 0.025 14.6 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 PIK39717.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) HMG_box PF00505.19 PIK39718.1 - 1.2e-25 89.7 1.5 2.2e-25 88.9 1.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK39718.1 - 1.4e-11 44.8 0.3 2.7e-11 43.9 0.3 1.5 1 0 0 1 1 1 1 HMG-box domain Sox_N PF12444.8 PIK39718.1 - 4e-06 27.9 2.9 6.8e-06 27.1 0.2 2.9 3 0 0 3 3 3 1 Sox developmental protein N terminal DUF4815 PF16075.5 PIK39718.1 - 0.016 13.5 0.0 0.023 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) Ras PF00071.22 PIK39720.1 - 6.8e-50 168.8 0.0 7.8e-50 168.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK39720.1 - 1.8e-18 66.9 0.0 2.5e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK39720.1 - 4.6e-06 26.2 0.0 7.3e-06 25.6 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK39720.1 - 0.0025 17.4 0.0 0.0036 16.9 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain adh_short PF00106.25 PIK39721.1 - 7.8e-32 110.3 0.1 9.9e-32 110.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39721.1 - 5.7e-27 94.8 0.1 8e-27 94.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39721.1 - 2.6e-09 37.2 0.1 3.6e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.13 PIK39721.1 - 0.0026 17.7 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family YjeF_N PF03853.15 PIK39721.1 - 0.036 14.0 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Helicase_RecD PF05127.14 PIK39721.1 - 0.045 13.6 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 Helicase 3HCDH_N PF02737.18 PIK39721.1 - 0.09 12.6 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 PIK39721.1 - 0.13 12.1 0.4 0.25 11.1 0.4 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein adh_short PF00106.25 PIK39722.1 - 1.3e-18 67.2 0.4 1.4e-18 67.1 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK39722.1 - 2.9e-15 56.5 0.2 3.5e-15 56.2 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK39722.1 - 3e-07 30.5 0.2 3.4e-07 30.3 0.2 1.0 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 PIK39722.1 - 0.0031 17.4 0.1 0.0035 17.3 0.1 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus 3HCDH_N PF02737.18 PIK39722.1 - 0.0032 17.4 0.4 0.0035 17.2 0.4 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_tran_WecB PF03808.13 PIK39722.1 - 0.0041 17.1 0.1 0.0048 16.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family Sacchrp_dh_NADP PF03435.18 PIK39722.1 - 0.023 15.0 0.1 0.029 14.6 0.1 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 PIK39722.1 - 0.034 13.8 0.1 0.051 13.2 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 PIK39722.1 - 0.035 13.5 0.1 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 PIK39722.1 - 0.062 13.2 0.3 0.086 12.7 0.3 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NAD_binding_2 PF03446.15 PIK39722.1 - 0.074 13.2 0.0 0.088 13.0 0.0 1.1 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Fibrinogen_C PF00147.18 PIK39724.1 - 1.2e-41 142.9 14.8 3e-41 141.7 14.8 1.6 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK39724.1 - 3.9e-07 30.2 15.3 3.9e-07 30.2 15.3 4.3 4 0 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK39725.1 - 1e-47 162.8 15.8 3.9e-47 160.9 15.8 1.8 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ANXA2R PF15721.5 PIK39725.1 - 6.4 7.2 11.8 1.1 9.8 0.4 2.9 2 1 0 2 2 2 0 Annexin-2 receptor Gal_Lectin PF02140.18 PIK39726.1 - 6.7e-14 52.1 4.7 9.1e-14 51.7 4.7 1.2 1 0 0 1 1 1 1 Galactose binding lectin domain BUD22 PF09073.10 PIK39726.1 - 4.9 6.4 27.2 5.3 6.3 27.2 1.1 1 0 0 1 1 1 0 BUD22 Gal_Lectin PF02140.18 PIK39727.1 - 1.8e-12 47.5 3.7 3.7e-12 46.5 3.7 1.6 1 0 0 1 1 1 1 Galactose binding lectin domain LRR_4 PF12799.7 PIK39727.1 - 8.3e-09 35.6 5.8 3e-05 24.3 1.4 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK39727.1 - 5.5e-05 22.9 6.4 0.00016 21.4 4.1 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 PIK39727.1 - 0.00017 21.1 1.7 0.00032 20.3 1.7 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 PIK39727.1 - 4.3 7.6 6.9 44 4.5 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 PIK39727.1 - 5 8.1 7.2 52 5.0 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat Mtp PF03821.16 PIK39728.1 - 1.6e-16 60.6 12.0 5.1e-09 36.1 1.3 2.0 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 PIK39728.1 - 0.0036 18.0 5.7 0.81 10.4 0.5 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4728) DUF2975 PF11188.8 PIK39728.1 - 3.7 7.4 8.7 4.9 7.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) Fibrinogen_C PF00147.18 PIK39729.1 - 3.1e-21 76.2 11.6 9.4e-15 55.0 9.5 3.0 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK39729.1 - 8.7e-09 35.2 10.6 8.7e-09 35.2 10.6 5.2 4 2 2 6 6 6 1 TILa domain TIL PF01826.17 PIK39729.1 - 1.5e-06 28.3 18.6 1.5e-06 28.3 18.6 4.6 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain RVT_1 PF00078.27 PIK39730.1 - 1.8e-10 40.7 0.0 3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cu-oxidase_2 PF07731.14 PIK39733.1 - 1e-16 60.9 0.1 1.1e-16 60.8 0.1 1.1 1 0 0 1 1 1 1 Multicopper oxidase Kinesin PF00225.23 PIK39734.1 - 5e-103 344.5 0.1 1.2e-102 343.2 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK39734.1 - 4.7e-27 94.7 0.0 1.8e-26 92.9 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding MbeB_N PF04837.12 PIK39734.1 - 0.064 13.6 0.8 0.19 12.1 0.8 1.8 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Atrophin-1 PF03154.15 PIK39734.1 - 0.54 8.5 6.1 0.96 7.7 6.1 1.4 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 PIK39734.1 - 3.4 7.7 7.8 0.98 9.4 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) SNF PF00209.18 PIK39735.1 - 2.7e-157 524.6 21.1 3e-157 524.5 21.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Metallophos PF00149.28 PIK39736.1 - 3.1e-26 93.2 0.1 4.8e-26 92.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 PIK39736.1 - 3.7e-05 23.0 2.3 0.0039 16.6 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK39736.1 - 0.00027 21.3 2.7 0.0007 20.0 1.6 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK39736.1 - 0.0011 18.7 2.3 0.079 12.9 0.6 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 PIK39736.1 - 0.009 15.8 0.2 0.15 11.9 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair DAG_kinase_N PF14513.6 PIK39736.1 - 0.066 13.4 1.9 0.44 10.7 1.9 2.2 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus V-set PF07686.17 PIK39737.1 - 3.6e-10 40.0 0.7 0.0012 19.0 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK39737.1 - 8.8e-05 23.0 0.6 1.6 9.3 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK39737.1 - 0.00096 19.3 0.1 1.3 9.3 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK39737.1 - 0.045 13.8 0.2 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK39737.1 - 0.14 12.3 0.1 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_6 PF18452.1 PIK39737.1 - 0.14 11.7 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain 7tm_1 PF00001.21 PIK39738.1 - 3.3e-10 39.7 0.2 4.6e-10 39.3 0.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK39738.1 - 3.7e-06 26.5 0.8 3.7e-06 26.5 0.8 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK39738.1 - 0.006 16.0 2.5 0.006 16.0 2.5 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF898 PF05987.13 PIK39738.1 - 0.064 12.3 6.3 0.086 11.9 3.4 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) GPR_Gpa2_C PF11970.8 PIK39738.1 - 0.072 13.2 3.0 0.11 12.5 1.9 1.8 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term cNMPbd_u2 PF16643.5 PIK39738.1 - 0.25 11.8 3.4 0.38 11.2 3.4 1.3 1 0 0 1 1 1 0 Unstructured region on cNMP-binding protein DUF5392 PF17370.2 PIK39738.1 - 2.8 8.0 4.3 1.1 9.3 0.4 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5392) C1_1 PF00130.22 PIK39739.1 - 5.3 7.0 8.6 0.42 10.5 3.8 1.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) VGCC_alpha2 PF08473.11 PIK39740.1 - 4.1e-16 58.8 5.6 6.2e-11 41.7 1.0 3.1 3 0 0 3 3 3 3 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.11 PIK39741.1 - 7.2e-14 52.3 0.0 1.7e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 VWA N-terminal VWA_3 PF13768.6 PIK39741.1 - 5e-10 39.5 0.0 7.5e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK39741.1 - 1e-09 38.9 0.1 1.7e-09 38.1 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK39741.1 - 1.1e-09 38.9 0.0 2.3e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain OAM_alpha PF16552.5 PIK39741.1 - 0.16 11.9 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 D-ornithine 4,5-aminomutase alpha-subunit Phage_integrase PF00589.22 PIK39742.1 - 0.0083 15.9 0.0 0.023 14.5 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family Herpes_BLLF1 PF05109.13 PIK39743.1 - 0.013 13.5 6.0 0.019 13.0 6.0 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RVT_3 PF13456.6 PIK39743.1 - 0.028 14.2 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like Collagen PF01391.18 PIK39743.1 - 1.6 8.5 8.0 0.55 10.0 3.8 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Raftlin PF15250.6 PIK39744.1 - 0.064 12.0 0.0 0.087 11.6 0.0 1.1 1 0 0 1 1 1 0 Raftlin PTCB-BRCT PF12738.7 PIK39745.1 - 2e-08 34.0 0.0 3.7e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 PIK39745.1 - 2.3e-08 34.3 0.0 4.9e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK39745.1 - 8.7e-06 26.1 0.0 2.3e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Peptidase_S64 PF08192.11 PIK39745.1 - 1.3 7.5 7.7 1.6 7.1 7.7 1.2 1 0 0 1 1 1 0 Peptidase family S64 SOBP PF15279.6 PIK39745.1 - 3.5 8.2 8.2 0.5 10.9 4.5 1.5 2 0 0 2 2 2 0 Sine oculis-binding protein ZU5 PF00791.20 PIK39747.1 - 5.8e-15 55.4 0.0 1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK39747.1 - 3.9e-11 43.0 0.1 8.1e-11 41.9 0.1 1.4 1 0 0 1 1 1 1 Death domain Cas9_Topo PF17894.1 PIK39747.1 - 0.15 12.1 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 ZU5 PF00791.20 PIK39748.1 - 2.3e-13 50.3 0.0 4.3e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK39750.1 - 1.2e-14 54.2 0.2 2e-14 53.5 0.2 1.3 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK39750.1 - 1e-12 48.2 0.0 1.9e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain UPA PF17217.3 PIK39750.1 - 0.022 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 UPA domain Death PF00531.22 PIK39751.1 - 1.1e-28 99.3 7.6 4.7e-15 55.5 0.5 2.4 2 0 0 2 2 2 2 Death domain ZU5 PF00791.20 PIK39751.1 - 2.9e-10 40.3 0.2 5.7e-10 39.4 0.2 1.5 1 0 0 1 1 1 1 ZU5 domain ZU5 PF00791.20 PIK39752.1 - 1e-11 45.0 0.0 2.9e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK39752.1 - 1.5e-05 25.2 1.0 0.052 13.9 0.3 2.4 2 0 0 2 2 2 2 Death effector domain UPA PF17217.3 PIK39752.1 - 0.0052 16.7 0.0 0.016 15.1 0.0 1.8 1 0 0 1 1 1 1 UPA domain BORA_N PF15280.6 PIK39752.1 - 0.066 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein aurora borealis N-terminus ZU5 PF00791.20 PIK39753.1 - 1.2e-13 51.2 0.0 2.6e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain ZU5 PF00791.20 PIK39754.1 - 1.6e-12 47.6 0.0 3.6e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain RVT_1 PF00078.27 PIK39755.1 - 1.7e-42 145.4 0.5 3e-42 144.6 0.2 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK39755.1 - 0.029 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 Med18 protein SUZ PF12752.7 PIK39757.1 - 9.8e-16 58.3 1.2 9.8e-16 58.3 1.2 1.8 2 0 0 2 2 2 1 SUZ domain TPR_1 PF00515.28 PIK39758.1 - 1.1e-12 47.2 0.5 0.00076 19.2 0.1 3.5 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK39758.1 - 2.7e-11 42.7 1.3 0.0085 16.1 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39758.1 - 6.6e-08 32.7 6.0 0.0014 18.8 0.2 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK39758.1 - 1.2e-07 32.2 0.3 4.1e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39758.1 - 1.4e-06 27.9 0.0 0.27 10.9 0.1 3.3 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 PIK39758.1 - 4.9e-05 23.4 1.6 0.0038 17.4 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39758.1 - 0.00026 21.0 0.2 0.93 9.9 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39758.1 - 0.00055 20.5 1.8 1.1 10.3 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK39758.1 - 0.00061 20.0 0.3 0.032 14.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK39758.1 - 0.003 17.4 4.7 2.2 8.2 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK39758.1 - 0.012 16.2 1.1 3.3 8.5 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39758.1 - 0.015 15.3 0.3 7.5 6.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK39758.1 - 0.015 15.8 0.4 0.015 15.8 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 PIK39758.1 - 0.04 12.8 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDO_I PF05995.12 PIK39759.1 - 0.0014 18.0 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 PIK39759.1 - 0.053 13.0 0.6 0.23 10.9 0.6 2.0 1 1 0 1 1 1 0 PCO_ADO OrfB_Zn_ribbon PF07282.11 PIK39760.1 - 0.014 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF4407 PF14362.6 PIK39760.1 - 0.33 10.2 11.4 0.47 9.8 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 PIK39761.1 - 2.3e-15 56.7 0.2 5.2e-08 33.4 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK39761.1 - 0.00044 20.5 0.1 0.00094 19.4 0.1 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK39761.1 - 0.012 15.5 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A SSF PF00474.17 PIK39762.1 - 5.5e-19 68.3 0.3 1.1e-18 67.4 0.3 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family Sigma_reg_N PF13800.6 PIK39762.1 - 3.2 8.1 5.2 2.3 8.6 0.1 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Bcl-2 PF00452.19 PIK39763.1 - 2.2e-22 79.6 0.5 6.1e-22 78.2 0.2 1.9 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family Neur_chan_memb PF02932.16 PIK39764.1 - 1.3e-15 58.2 3.9 1.8e-15 57.7 3.8 1.6 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PRIMA1 PF16101.5 PIK39764.1 - 0.4 10.7 5.3 0.11 12.5 1.4 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Neur_chan_memb PF02932.16 PIK39765.1 - 1.4e-26 94.1 0.1 1.8e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK39765.1 - 4.4e-07 29.6 0.1 8.2e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain FMN_dh PF01070.18 PIK39766.1 - 1e-96 324.0 0.0 1.3e-96 323.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK39766.1 - 7.9e-09 35.0 0.1 1.9e-08 33.7 0.0 1.6 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK39766.1 - 4.3e-07 29.4 0.0 6.9e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK39766.1 - 0.00022 20.7 0.1 0.00032 20.2 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK39766.1 - 0.00071 19.1 0.0 0.0024 17.4 0.0 1.8 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 PIK39766.1 - 0.0066 15.8 0.1 1.3 8.2 0.0 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 PIK39766.1 - 0.013 14.6 0.0 0.058 12.5 0.0 1.9 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) PA PF02225.22 PIK39766.1 - 0.28 11.2 1.8 3.8 7.6 0.0 2.7 3 0 0 3 3 3 0 PA domain Neur_chan_memb PF02932.16 PIK39767.1 - 2e-18 67.3 3.1 5.4e-16 59.4 0.2 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF5453 PF17534.2 PIK39767.1 - 0.42 10.6 2.2 1.5 8.7 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5453) Neur_chan_memb PF02932.16 PIK39768.1 - 9e-18 65.2 6.5 1.3e-16 61.4 3.2 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK39768.1 - 1e-05 25.1 0.3 1.5e-05 24.5 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain LPG_synthase_TM PF03706.13 PIK39768.1 - 0.042 13.4 3.3 0.082 12.4 0.1 2.1 2 0 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region Neur_chan_memb PF02932.16 PIK39769.1 - 1e-11 45.4 6.1 1.5e-07 31.7 1.1 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region 7tm_1 PF00001.21 PIK39770.1 - 2.5e-45 154.8 21.2 3.3e-45 154.5 21.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39770.1 - 3.7e-07 30.0 16.5 5.5e-07 29.5 16.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK39770.1 - 5.6e-07 29.2 8.4 5.6e-07 29.2 8.4 1.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK39770.1 - 1.4e-05 24.6 17.3 1.9e-05 24.2 17.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK39770.1 - 0.0011 18.8 13.8 0.0089 15.8 13.8 2.1 1 1 0 1 1 1 1 Olfactory receptor BPL_LplA_LipB PF03099.19 PIK39772.1 - 2.2e-07 30.8 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family FERM_N PF09379.10 PIK39772.1 - 0.025 14.5 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 FERM N-terminal domain C1q PF00386.21 PIK39773.1 - 1.3e-23 83.6 0.2 2.3e-23 82.8 0.2 1.5 1 0 0 1 1 1 1 C1q domain HALZ PF02183.18 PIK39773.1 - 6.3e-05 23.1 0.2 0.044 14.0 0.0 2.6 2 0 0 2 2 2 1 Homeobox associated leucine zipper FlaC_arch PF05377.11 PIK39773.1 - 0.00033 21.0 4.5 0.11 12.9 0.7 3.6 2 1 1 3 3 3 1 Flagella accessory protein C (FlaC) BclA_C PF18573.1 PIK39773.1 - 0.00083 19.3 0.1 0.0019 18.1 0.1 1.6 1 0 0 1 1 1 1 BclA C-terminal domain FPP PF05911.11 PIK39773.1 - 0.0028 15.9 1.3 0.0039 15.5 1.3 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 PIK39773.1 - 0.012 15.9 2.4 0.042 14.1 2.2 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 PIK39773.1 - 0.03 14.4 1.6 0.44 10.7 0.2 2.9 3 0 0 3 3 3 0 bZIP transcription factor HSBP1 PF06825.12 PIK39773.1 - 0.031 14.1 1.2 0.031 14.1 1.2 3.0 3 1 0 3 3 3 0 Heat shock factor binding protein 1 Leu_zip PF15294.6 PIK39773.1 - 0.035 13.6 3.9 0.071 12.6 2.5 1.9 2 0 0 2 2 2 0 Leucine zipper Prefoldin_3 PF13758.6 PIK39773.1 - 0.038 14.0 1.1 0.096 12.8 1.1 1.7 1 0 0 1 1 1 0 Prefoldin subunit TSC22 PF01166.18 PIK39773.1 - 0.04 14.2 0.2 0.14 12.5 0.2 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family GAS PF13851.6 PIK39773.1 - 0.097 12.0 3.5 0.13 11.6 2.4 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 PIK39773.1 - 0.19 11.5 5.9 2.2 8.1 0.3 3.7 2 1 1 3 3 3 0 Septum formation initiator ADIP PF11559.8 PIK39773.1 - 0.74 9.9 7.9 0.52 10.4 2.4 2.8 2 2 0 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 PIK39773.1 - 0.85 9.8 5.9 0.28 11.4 2.7 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4988 PF16378.5 PIK39773.1 - 0.91 9.2 4.0 2.7 7.6 0.7 2.4 1 1 1 2 2 2 0 Domain of unknown function CENP-F_leu_zip PF10473.9 PIK39773.1 - 1.7 8.7 6.4 0.61 10.1 1.9 2.5 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 PIK39773.1 - 3.1 8.2 9.9 20 5.7 0.0 3.7 4 0 0 4 4 3 0 Lipoprotein leucine-zipper YabA PF06156.13 PIK39773.1 - 3.2 8.5 4.9 5.5 7.7 2.3 2.5 2 1 1 3 3 3 0 Initiation control protein YabA BLOC1_2 PF10046.9 PIK39773.1 - 4.1 7.8 8.6 1.9 8.8 1.5 3.1 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 PIK39773.1 - 5.2 7.8 9.5 19 6.0 0.0 3.6 2 2 1 3 3 3 0 SlyX C1q PF00386.21 PIK39774.1 - 3.7e-22 78.9 0.8 5.4e-22 78.4 0.1 1.7 2 0 0 2 2 2 1 C1q domain BclA_C PF18573.1 PIK39774.1 - 0.0004 20.3 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 BclA C-terminal domain PHC2_SAM_assoc PF16616.5 PIK39774.1 - 0.0025 18.6 2.3 0.0025 18.6 2.3 1.7 2 0 0 2 2 2 1 Unstructured region on Polyhomeotic-like protein 1 and 2 cwf21 PF08312.12 PIK39774.1 - 8.9 6.6 7.4 20 5.4 0.0 2.6 2 1 0 2 2 2 0 cwf21 domain DASH_Duo1 PF08651.10 PIK39775.1 - 0.02 14.7 0.7 0.02 14.7 0.7 2.6 2 0 0 2 2 2 0 DASH complex subunit Duo1 HATPase_c_2 PF13581.6 PIK39775.1 - 0.11 12.5 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain DUF4728 PF15860.5 PIK39777.1 - 0.016 15.8 16.0 0.016 15.8 16.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) PTPLA PF04387.14 PIK39777.1 - 0.079 12.7 4.0 0.3 10.8 4.0 1.9 1 1 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA Tetraspanin PF00335.20 PIK39777.1 - 0.5 10.0 16.4 2.9 7.6 16.6 1.9 1 1 1 2 2 2 0 Tetraspanin family Neurensin PF14927.6 PIK39777.1 - 1 9.1 5.7 2.3 7.9 5.7 1.8 1 1 0 1 1 1 0 Neurensin Transglut_N PF00868.20 PIK39778.1 - 5.8e-27 94.4 0.0 8.4e-26 90.7 0.0 2.8 3 0 0 3 3 3 1 Transglutaminase family Transglut_C PF00927.22 PIK39778.1 - 6.4e-26 90.6 0.1 1.3e-12 47.8 0.0 2.3 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 PIK39778.1 - 2.6e-13 50.4 0.0 8e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily Glutaredoxin PF00462.24 PIK39779.1 - 7.5e-15 54.9 0.1 1.5e-14 53.9 0.1 1.5 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 PIK39779.1 - 7.9e-05 23.0 0.0 0.00014 22.2 0.0 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 PIK39779.1 - 0.00059 19.7 0.8 0.0076 16.1 0.1 2.2 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 PIK39779.1 - 0.0027 17.7 0.1 0.0041 17.1 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin domain GST_N_3 PF13417.6 PIK39779.1 - 0.0029 18.0 0.0 0.0038 17.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 PIK39779.1 - 0.048 14.1 0.1 0.064 13.7 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_4 PF13462.6 PIK39779.1 - 0.072 13.2 0.8 2.4 8.3 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin HUN PF08729.10 PIK39781.1 - 2.4e-08 33.8 0.2 4.6e-08 32.9 0.2 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Ldl_recept_b PF00058.17 PIK39782.1 - 5.2e-25 87.6 3.3 1.7e-11 44.4 0.1 5.0 4 1 1 5 5 5 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK39782.1 - 0.059 12.9 0.1 0.63 9.6 0.0 2.3 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Mesothelin PF06060.12 PIK39783.1 - 4.9e-09 34.9 0.1 1e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Trypan_PARP PF05887.11 PIK39783.1 - 0.00095 19.1 8.0 0.0017 18.3 8.0 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Prefoldin PF02996.17 PIK39784.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit Profilin PF00235.19 PIK39785.1 - 0.037 14.3 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 Profilin LRR_8 PF13855.6 PIK39786.1 - 9.9e-16 57.3 9.7 2.2e-10 40.1 0.9 2.8 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK39786.1 - 6.3e-05 23.3 14.2 0.0036 17.7 0.8 3.6 3 2 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK39786.1 - 0.041 14.4 8.9 8.9 7.3 0.1 5.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK39786.1 - 3.8 7.8 6.9 25 5.3 0.8 3.7 3 0 0 3 3 3 0 Leucine Rich repeat Ig_3 PF13927.6 PIK39787.1 - 0.002 18.7 0.1 0.35 11.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain LRAT PF04970.13 PIK39788.1 - 3.3e-09 37.1 3.4 4.4e-06 27.0 3.4 2.7 1 1 0 1 1 1 1 Lecithin retinol acyltransferase DED PF01335.21 PIK39788.1 - 0.0073 16.6 3.0 1.8 9.0 0.2 4.0 3 1 0 3 3 3 1 Death effector domain NLPC_P60 PF00877.19 PIK39788.1 - 0.046 13.8 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family FGE-sulfatase PF03781.16 PIK39789.1 - 6.3e-20 71.8 0.4 6.9e-20 71.7 0.4 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 FGE-sulfatase PF03781.16 PIK39790.1 - 8.3e-30 104.2 0.2 1e-29 103.9 0.2 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Baculo_VP91_N PF08475.10 PIK39790.1 - 0.04 13.6 0.4 0.063 13.0 0.4 1.3 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal Pkinase PF00069.25 PIK39791.1 - 8.6e-59 199.1 0.0 2.9e-58 197.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK39791.1 - 2.9e-21 75.9 0.0 6.4e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK39791.1 - 3.7e-06 26.4 0.0 8e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK39791.1 - 0.00028 20.3 0.0 0.00047 19.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 PIK39791.1 - 0.0086 15.7 0.1 0.49 10.0 0.0 2.6 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 PIK39791.1 - 0.032 13.8 0.2 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 PIK39791.1 - 0.085 12.8 0.1 0.26 11.2 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family EF-hand_9 PF14658.6 PIK39791.1 - 0.16 12.3 1.9 1.4 9.3 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain rve PF00665.26 PIK39792.1 - 1.7e-21 76.6 0.0 2.9e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK39792.1 - 0.00029 20.5 0.0 0.00061 19.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK39793.1 - 1.8e-35 121.4 0.1 3.4e-35 120.5 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK39793.1 - 1.3e-26 92.5 0.1 2.2e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK39794.1 - 2.6e-20 72.9 0.0 3.7e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK39794.1 - 0.00024 21.3 0.0 0.44 10.7 0.0 2.2 1 1 1 2 2 2 2 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.6 PIK39795.1 - 0.00068 19.4 1.4 0.0014 18.4 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK39795.1 - 0.0025 17.8 2.9 0.0042 17.1 2.9 1.4 1 0 0 1 1 1 1 Zinc knuckle DUF86 PF01934.17 PIK39795.1 - 0.013 15.4 0.3 0.029 14.2 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF86 Glyoxalase PF00903.25 PIK39797.1 - 7e-16 58.6 0.1 9.8e-16 58.1 0.1 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 PIK39797.1 - 0.0021 18.3 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MutS_IV PF05190.18 PIK39797.1 - 0.05 14.0 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 MutS family domain IV Glyoxalase_3 PF13468.6 PIK39797.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain PARP_reg PF02877.14 PIK39798.1 - 8.7e-41 139.2 1.4 2.4e-40 137.8 1.4 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PARP PF00644.20 PIK39798.1 - 7.9e-35 120.2 0.0 7.9e-35 120.2 0.0 3.2 4 1 0 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 PIK39798.1 - 1.7e-27 95.3 2.3 4.4e-27 93.9 2.3 1.8 1 0 0 1 1 1 1 WGR domain Peptidase_S9 PF00326.21 PIK39799.1 - 2.8e-33 115.2 0.0 4.2e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 PIK39799.1 - 3e-09 36.9 0.5 2.4e-05 24.1 0.5 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 PIK39799.1 - 3.6e-08 33.2 0.0 3.1e-07 30.2 0.0 2.3 2 1 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 PIK39799.1 - 1.6e-07 30.9 0.4 0.0053 16.1 0.0 2.3 1 1 0 2 2 2 2 Serine aminopeptidase, S33 COesterase PF00135.28 PIK39799.1 - 7.6e-05 21.8 0.2 0.00014 20.9 0.2 1.4 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 PIK39799.1 - 0.0039 17.8 0.1 0.0065 17.1 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 PIK39799.1 - 0.054 12.2 0.0 0.37 9.4 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 PIK39799.1 - 0.076 12.9 0.0 1.3 8.8 0.1 2.4 2 1 0 2 2 2 0 alpha/beta hydrolase fold PD40 PF07676.12 PIK39799.1 - 0.092 12.7 0.0 0.83 9.7 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat FSH1 PF03959.13 PIK39799.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Propep_M14 PF02244.16 PIK39799.1 - 0.13 12.7 0.0 0.87 10.0 0.0 2.2 2 0 0 2 2 2 0 Carboxypeptidase activation peptide UQ_con PF00179.26 PIK39800.1 - 1.7e-24 86.0 0.0 2.5e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK39800.1 - 0.00063 19.6 0.0 0.00094 19.0 0.0 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 PIK39800.1 - 0.0069 16.7 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK39800.1 - 0.01 15.5 0.0 0.023 14.4 0.0 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B 7tm_1 PF00001.21 PIK39801.1 - 9.6e-30 103.8 16.6 1.3e-29 103.4 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CUB PF00431.20 PIK39802.1 - 4.7e-30 104.2 0.0 4e-25 88.3 0.0 2.1 2 0 0 2 2 2 2 CUB domain RVT_1 PF00078.27 PIK39803.1 - 2.9e-45 154.5 0.3 6.1e-45 153.4 0.3 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CUB PF00431.20 PIK39803.1 - 1.8e-22 79.7 0.0 7e-22 77.9 0.0 2.0 2 0 0 2 2 2 1 CUB domain Exo_endo_phos_2 PF14529.6 PIK39803.1 - 9.2e-07 28.7 0.4 2.5e-06 27.4 0.4 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK39803.1 - 0.00066 19.3 0.0 0.0031 17.0 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Retrotran_gag_2 PF14223.6 PIK39803.1 - 0.023 14.4 2.0 0.054 13.2 1.0 2.1 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type TALPID3 PF15324.6 PIK39803.1 - 0.39 8.3 1.4 0.56 7.8 1.4 1.1 1 0 0 1 1 1 0 Hedgehog signalling target CUB PF00431.20 PIK39804.1 - 9.9e-47 157.8 1.1 5.8e-21 74.9 0.0 4.0 4 0 0 4 4 4 4 CUB domain CUB PF00431.20 PIK39805.1 - 2.2e-59 198.6 0.0 5.9e-25 87.8 0.0 4.6 5 0 0 5 5 5 4 CUB domain IL4Ra_N PF09238.10 PIK39805.1 - 0.072 13.4 0.0 15 6.0 0.0 3.0 3 0 0 3 3 3 0 Interleukin-4 receptor alpha chain, N-terminal PHM7_cyt PF14703.6 PIK39806.1 - 1.9e-37 129.2 0.0 2.5e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 PIK39806.1 - 2.4e-22 79.4 0.1 4e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport DUF4810 PF16068.5 PIK39806.1 - 0.074 13.6 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) Glyco_hydro_115 PF15979.5 PIK39806.1 - 0.15 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 115 Baculo_11_kDa PF06143.11 PIK39806.1 - 8.7 6.0 6.3 33 4.1 0.1 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family RSN1_7TM PF02714.15 PIK39807.1 - 1.4e-20 73.8 7.7 1.4e-20 73.8 7.7 2.2 1 1 1 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate MgtE PF01769.16 PIK39807.1 - 1.6 9.1 11.1 16 5.9 11.1 2.5 1 1 0 1 1 1 0 Divalent cation transporter BRE PF06113.12 PIK39810.1 - 7.8e-92 307.5 1.0 9.2e-92 307.3 1.0 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) Arf PF00025.21 PIK39811.1 - 1.9e-58 196.8 0.0 2.1e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK39811.1 - 1.6e-13 50.9 0.0 4.7e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK39811.1 - 1.6e-12 47.3 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 PIK39811.1 - 1.3e-10 41.0 0.0 1.8e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK39811.1 - 7.3e-08 32.0 0.0 9.5e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 PIK39811.1 - 2.3e-07 30.3 0.3 0.00023 20.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK39811.1 - 0.00032 20.8 0.0 0.00056 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 PIK39811.1 - 0.021 15.4 0.0 0.042 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 PIK39811.1 - 0.046 13.3 0.2 0.081 12.5 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 PIK39811.1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK39811.1 - 0.19 12.3 0.1 0.41 11.1 0.1 1.8 1 1 0 1 1 1 0 ABC transporter Ras PF00071.22 PIK39812.1 - 3.9e-46 156.6 0.0 4.5e-46 156.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK39812.1 - 1.3e-22 80.3 0.0 1.9e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK39812.1 - 2.9e-10 39.9 0.0 3.8e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK39812.1 - 0.0004 20.0 0.0 0.00099 18.7 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CCSAP PF15748.5 PIK39813.1 - 7e-19 69.0 3.9 8.3e-19 68.8 3.9 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Arg_decarbox_C PF17944.1 PIK39813.1 - 0.12 13.0 0.2 0.23 12.0 0.2 1.5 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension KDZ PF18758.1 PIK39814.1 - 2.8e-05 23.9 0.0 4.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase Mucin PF01456.17 PIK39814.1 - 3.8 7.5 12.4 9.1 6.3 12.4 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein CD225 PF04505.12 PIK39817.1 - 1.7e-24 85.7 0.5 1.7e-24 85.7 0.5 1.4 1 1 0 1 1 1 1 Interferon-induced transmembrane protein UPF0220 PF05255.11 PIK39817.1 - 0.0024 17.4 0.1 0.0025 17.4 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Claudin_2 PF13903.6 PIK39817.1 - 0.16 11.7 4.4 0.35 10.6 0.1 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction TMIE PF16038.5 PIK39817.1 - 7 6.6 6.3 2.4 8.1 1.4 2.2 2 0 0 2 2 2 0 TMIE protein PSP94 PF05825.11 PIK39818.1 - 3.7e-11 43.4 6.0 4.6e-11 43.1 6.0 1.0 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) Pacifastin_I PF05375.13 PIK39818.1 - 0.06 13.1 9.1 0.06 13.1 9.1 1.8 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) VWC PF00093.18 PIK39818.1 - 1.8 8.9 15.2 6.6 7.1 15.2 1.9 1 1 0 1 1 1 0 von Willebrand factor type C domain GDNF PF02351.16 PIK39819.1 - 5.2e-06 27.3 11.2 5.2e-06 27.3 11.2 3.9 4 1 1 5 5 5 2 GDNF/GAS1 domain La PF05383.17 PIK39820.1 - 0.1 12.6 0.0 0.3 11.2 0.0 1.8 1 0 0 1 1 1 0 La domain THAP PF05485.12 PIK39821.1 - 2e-14 54.3 1.8 3.5e-14 53.5 1.8 1.4 1 0 0 1 1 1 1 THAP domain Death PF00531.22 PIK39822.1 - 9.1e-14 51.4 0.1 2.1e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 Death domain UPA PF17217.3 PIK39822.1 - 0.0028 17.5 0.1 0.0066 16.3 0.1 1.6 1 0 0 1 1 1 1 UPA domain YrpD PF15493.6 PIK39822.1 - 0.24 11.2 1.6 3.7 7.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function, YrpD NACHT PF05729.12 PIK39823.1 - 3.2e-15 56.4 0.0 6.7e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK39823.1 - 7.7e-05 22.3 0.0 0.00042 19.9 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 PIK39823.1 - 0.0001 22.8 0.4 0.00084 19.8 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DED PF01335.21 PIK39823.1 - 0.00015 22.0 0.3 0.054 13.8 0.2 2.7 2 0 0 2 2 2 2 Death effector domain ATPase PF06745.13 PIK39823.1 - 0.016 14.5 0.0 0.044 13.1 0.0 1.7 1 0 0 1 1 1 0 KaiC DAP3 PF10236.9 PIK39823.1 - 0.038 13.2 0.0 0.091 11.9 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.21 PIK39823.1 - 0.065 12.6 0.0 0.3 10.4 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK39823.1 - 0.083 12.9 0.0 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 PIK39823.1 - 0.12 11.8 0.0 3.9 6.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Dimer_Tnp_hAT PF05699.14 PIK39824.1 - 8.4e-05 22.3 0.2 0.00016 21.4 0.2 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SAM_1 PF00536.30 PIK39824.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HECT PF00632.25 PIK39825.1 - 0.0033 16.9 0.0 0.007 15.9 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPX PF03105.19 PIK39825.1 - 0.13 12.2 4.7 0.21 11.5 4.7 1.4 1 0 0 1 1 1 0 SPX domain rve PF00665.26 PIK39826.1 - 2.7e-05 24.3 0.0 9.1e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_2 PF07727.14 PIK39827.1 - 5.5e-71 239.0 0.0 8.4e-71 238.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK39827.1 - 2.8e-19 69.4 0.0 1.3e-18 67.3 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Retrotran_gag_2 PF14223.6 PIK39827.1 - 1.6e-18 66.7 1.1 3.7e-18 65.5 1.1 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 PIK39827.1 - 8.3e-06 25.6 2.7 2.7e-05 24.0 2.7 2.0 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 PIK39827.1 - 0.00041 20.2 0.2 0.00041 20.2 0.2 3.3 3 0 0 3 3 3 1 GAG-pre-integrase domain rve_3 PF13683.6 PIK39827.1 - 0.018 14.8 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.6 PIK39827.1 - 5.3 6.9 7.2 3.2 7.6 2.1 2.6 2 0 0 2 2 2 0 Zinc knuckle EGF_CA PF07645.15 PIK39828.1 - 3.1e-32 110.5 85.9 6.5e-09 35.9 16.6 6.0 6 0 0 6 6 6 5 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39828.1 - 6.5e-27 93.4 86.0 2e-11 43.9 16.3 6.1 6 0 0 6 6 6 5 EGF domain cEGF PF12662.7 PIK39828.1 - 7e-16 57.8 59.2 1.2e-05 25.1 3.7 6.4 5 1 0 5 5 5 5 Complement Clr-like EGF-like EGF PF00008.27 PIK39828.1 - 9.5e-15 54.6 72.6 0.00074 19.8 10.7 6.1 5 1 0 5 5 5 5 EGF-like domain FXa_inhibition PF14670.6 PIK39828.1 - 2.1e-13 50.3 81.1 1e-07 32.1 7.1 5.5 5 0 0 5 5 5 5 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK39828.1 - 6.2e-11 42.2 62.7 0.0041 17.1 6.0 5.5 5 0 0 5 5 5 5 MSP1 EGF domain 1 hEGF PF12661.7 PIK39828.1 - 1.6e-09 38.1 67.1 0.00046 20.7 9.7 8.0 8 0 0 8 8 8 5 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK39828.1 - 0.006 16.9 67.2 0.029 14.7 6.6 6.0 4 1 1 5 5 5 3 Pvs28 EGF domain EGF_CA PF07645.15 PIK39829.1 - 4.1e-62 206.1 160.5 1.6e-10 41.0 12.0 10.4 10 0 0 10 10 10 9 Calcium-binding EGF domain cEGF PF12662.7 PIK39829.1 - 2.6e-42 142.3 81.1 4.7e-07 29.6 4.1 9.8 9 0 0 9 9 9 8 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK39829.1 - 3.6e-40 135.9 146.5 6.5e-11 42.2 9.7 10.8 10 1 0 10 10 10 9 EGF domain EGF PF00008.27 PIK39829.1 - 1.4e-14 54.0 131.6 0.00034 20.8 8.6 11.1 10 0 0 10 10 10 8 EGF-like domain hEGF PF12661.7 PIK39829.1 - 8.9e-12 45.2 118.0 0.002 18.7 5.1 12.7 11 1 0 11 11 11 8 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK39829.1 - 8.6e-11 42.0 118.4 0.008 16.5 10.1 10.6 10 0 0 10 10 10 8 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 PIK39829.1 - 1.2e-07 31.7 122.3 0.0007 19.6 6.4 10.6 10 0 0 10 10 10 6 MSP1 EGF domain 1 SEA PF01390.20 PIK39829.1 - 1.9e-07 31.1 1.5 0.0058 16.7 0.2 2.9 3 0 0 3 3 3 2 SEA domain FXa_inhibition PF14670.6 PIK39829.1 - 1.3e-06 28.5 134.6 0.11 12.8 9.6 10.6 8 2 2 10 10 10 8 Coagulation Factor Xa inhibitory site EB PF01683.18 PIK39829.1 - 0.0045 17.2 2.6 0.0045 17.2 2.6 10.4 6 3 3 10 10 10 4 EB module MHB PF16525.5 PIK39830.1 - 2.4e-05 24.5 2.8 0.81 10.0 0.1 3.4 1 1 0 3 3 3 2 Haemophore, haem-binding Amidase02_C PF12123.8 PIK39830.1 - 0.16 11.7 3.5 12 5.7 0.1 2.9 3 0 0 3 3 3 0 N-acetylmuramoyl-l-alanine amidase RRM_9 PF18444.1 PIK39830.1 - 0.23 11.3 1.4 19 5.2 0.1 2.2 2 0 0 2 2 2 0 RNA recognition motif PapD_N PF00345.20 PIK39830.1 - 1.5 8.7 5.3 1.8 8.5 1.3 2.3 1 1 2 3 3 3 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain VWD PF00094.25 PIK39831.1 - 1.2e-15 58.1 0.1 1.2e-15 58.1 0.1 2.3 2 1 1 3 3 3 1 von Willebrand factor type D domain RNA_pol_Rpb2_45 PF10385.9 PIK39831.1 - 0.055 13.7 3.3 13 6.2 0.0 5.0 6 0 0 6 6 6 0 RNA polymerase beta subunit external 1 domain EGF_CA PF07645.15 PIK39832.1 - 4.7e-15 55.5 29.8 8.2e-09 35.5 16.8 5.1 5 1 1 6 6 6 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39832.1 - 1.1e-10 41.5 16.7 1.1e-10 41.5 16.7 4.5 4 1 0 4 4 4 2 EGF domain FXa_inhibition PF14670.6 PIK39832.1 - 2e-06 27.9 6.6 2e-06 27.9 6.6 3.9 3 1 0 3 3 3 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK39832.1 - 2.3e-06 27.4 17.6 2.2e-05 24.3 3.2 3.8 3 1 0 3 3 3 2 Complement Clr-like EGF-like EGF PF00008.27 PIK39832.1 - 3.5e-06 27.2 40.5 0.00095 19.4 10.7 5.1 4 1 0 4 4 4 3 EGF-like domain EGF_MSP1_1 PF12946.7 PIK39832.1 - 0.01 15.8 9.5 0.01 15.8 9.5 3.4 4 0 0 4 4 4 0 MSP1 EGF domain 1 hEGF PF12661.7 PIK39832.1 - 0.016 15.8 28.6 0.31 11.8 6.0 5.4 6 0 0 6 6 6 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK39832.1 - 2.1 8.7 34.3 0.12 12.7 10.9 3.6 4 0 0 4 4 4 0 Pvs28 EGF domain EGF_CA PF07645.15 PIK39833.1 - 5e-62 205.9 108.3 6.7e-11 42.2 12.0 7.2 7 0 0 7 7 7 7 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39833.1 - 2.6e-44 149.1 111.9 1.5e-10 41.1 9.9 7.4 7 0 0 7 7 7 7 EGF domain cEGF PF12662.7 PIK39833.1 - 5.5e-43 144.5 62.9 4.9e-08 32.8 6.7 6.8 6 0 0 6 6 6 6 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK39833.1 - 1.3e-18 66.7 80.7 1.3e-06 28.3 7.4 6.6 7 0 0 7 7 7 6 MSP1 EGF domain 1 EGF PF00008.27 PIK39833.1 - 2.2e-17 63.0 88.2 5.9e-05 23.3 4.6 8.7 7 2 1 8 8 8 6 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK39833.1 - 2.1e-16 60.0 89.1 3.8e-07 30.3 6.7 7.0 7 0 0 7 7 7 5 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK39833.1 - 2.8e-11 43.5 94.0 0.024 14.9 7.2 7.5 5 3 2 7 7 7 6 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK39833.1 - 3.2e-08 33.9 90.8 0.013 16.1 2.2 9.9 9 2 1 10 10 10 6 Human growth factor-like EGF EGF_2 PF07974.13 PIK39833.1 - 0.032 14.6 94.7 0.051 13.9 11.2 7.5 6 1 1 7 7 7 0 EGF-like domain Cadherin_5 PF17892.1 PIK39833.1 - 0.063 13.3 0.4 2.4 8.2 0.0 3.3 3 1 1 4 4 4 0 Cadherin-like domain EGF_CA PF07645.15 PIK39834.1 - 2.9e-13 49.8 16.6 1.8e-10 40.8 6.9 2.2 2 0 0 2 2 2 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39834.1 - 1.4e-05 25.1 7.3 1.4e-05 25.1 7.3 2.4 2 1 0 2 2 2 1 EGF domain EGF PF00008.27 PIK39834.1 - 0.00034 20.8 8.0 0.00034 20.8 8.0 1.9 2 1 0 2 2 2 1 EGF-like domain hEGF PF12661.7 PIK39834.1 - 0.00089 19.8 3.5 0.00089 19.8 3.5 2.5 2 1 1 3 3 3 1 Human growth factor-like EGF cEGF PF12662.7 PIK39834.1 - 0.0074 16.2 1.7 0.0074 16.2 1.7 2.9 3 0 0 3 3 3 1 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 PIK39834.1 - 0.0099 16.2 1.6 0.0099 16.2 1.6 2.3 2 0 0 2 2 2 1 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK39834.1 - 0.011 16.0 6.7 0.011 16.0 6.7 2.1 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site S_locus_glycop PF00954.20 PIK39834.1 - 0.026 15.1 1.7 0.038 14.5 1.2 1.7 1 1 0 1 1 1 0 S-locus glycoprotein domain EB PF01683.18 PIK39834.1 - 1.5 9.1 10.1 0.059 13.7 3.9 1.8 2 0 0 2 2 2 0 EB module MHB PF16525.5 PIK39836.1 - 0.0062 16.8 15.9 23 5.3 0.1 7.7 8 1 1 9 9 9 4 Haemophore, haem-binding Amidase02_C PF12123.8 PIK39836.1 - 2.9 7.7 8.3 47 3.8 0.5 4.4 3 0 0 3 3 3 0 N-acetylmuramoyl-l-alanine amidase EGF_CA PF07645.15 PIK39837.1 - 9.3e-32 109.0 44.4 1.4e-11 44.4 12.0 3.1 3 0 0 3 3 3 3 Calcium-binding EGF domain EGF_3 PF12947.7 PIK39837.1 - 9.2e-19 67.4 44.1 6.2e-10 39.1 13.3 3.6 3 1 0 3 3 3 3 EGF domain cEGF PF12662.7 PIK39837.1 - 1.5e-16 60.0 33.9 5.6e-08 32.6 4.1 4.4 4 0 0 4 4 4 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK39837.1 - 3.3e-08 33.7 41.7 0.039 14.2 9.9 3.5 2 1 1 3 3 3 3 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK39837.1 - 2.1e-07 31.1 39.9 0.0001 22.5 7.0 4.2 3 2 0 4 4 4 3 EGF-like domain EGF_MSP1_1 PF12946.7 PIK39837.1 - 7.4e-07 29.1 25.5 0.011 15.8 8.8 3.5 3 0 0 3 3 3 3 MSP1 EGF domain 1 hEGF PF12661.7 PIK39837.1 - 7.5e-07 29.6 35.3 0.00072 20.1 3.6 5.0 3 1 1 4 4 4 3 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK39837.1 - 1.3e-05 25.4 29.9 0.0074 16.6 1.6 3.4 3 0 0 3 3 3 3 Pvs28 EGF domain EGF_2 PF07974.13 PIK39837.1 - 0.7 10.3 41.0 4.8 7.6 5.1 4.0 3 2 0 3 3 3 0 EGF-like domain DUF167 PF02594.16 PIK39838.1 - 2e-22 79.0 0.2 3.3e-22 78.4 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 zf-H2C2_2 PF13465.6 PIK39840.1 - 2.6e-47 157.2 88.3 2.7e-07 30.7 1.1 11.2 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK39840.1 - 7.8e-21 73.0 97.1 0.00094 19.8 4.6 11.9 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK39840.1 - 5.5e-17 61.2 101.3 0.01 16.3 0.6 12.1 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK39840.1 - 3.2e-09 36.8 62.9 0.029 14.6 2.5 11.7 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK39840.1 - 0.00016 21.4 0.9 0.00016 21.4 0.9 10.2 11 1 0 11 11 11 2 C2H2-type zinc-finger domain zf-met2 PF12907.7 PIK39840.1 - 0.049 13.8 0.3 0.049 13.8 0.3 7.7 10 2 1 11 11 11 0 Zinc-binding zf-Di19 PF05605.12 PIK39840.1 - 0.053 13.8 62.4 0.043 14.1 6.6 7.8 5 3 2 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 PIK39840.1 - 0.24 11.3 37.2 0.53 10.2 0.1 7.8 9 0 0 9 9 9 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 PIK39840.1 - 5.8 7.4 64.6 1.6 9.2 5.3 8.3 4 3 3 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger AAA PF00004.29 PIK39841.1 - 6.9e-42 143.0 0.0 1.1e-41 142.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK39841.1 - 9.5e-11 41.3 0.0 1.9e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 PIK39841.1 - 6.7e-06 26.3 0.0 2e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 PIK39841.1 - 7.6e-06 26.4 0.2 4.9e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 PIK39841.1 - 2e-05 24.4 0.0 5.5e-05 23.0 0.0 1.6 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 PIK39841.1 - 0.00042 20.6 0.2 0.0089 16.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK39841.1 - 0.0016 18.4 0.0 0.014 15.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 PIK39841.1 - 0.0018 18.8 0.0 0.0048 17.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 PIK39841.1 - 0.0035 17.5 0.0 0.0057 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK39841.1 - 0.0037 17.3 0.0 0.0057 16.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RuvB_N PF05496.12 PIK39841.1 - 0.0049 16.6 0.0 0.016 15.0 0.0 1.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 PIK39841.1 - 0.0065 15.8 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.13 PIK39841.1 - 0.01 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 PIK39841.1 - 0.014 15.3 0.1 0.056 13.3 0.1 2.1 2 1 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 PIK39841.1 - 0.015 15.7 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 PIK39841.1 - 0.017 15.0 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 PIK39841.1 - 0.021 14.5 0.0 0.059 13.1 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 PIK39841.1 - 0.028 13.9 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Torsin PF06309.11 PIK39841.1 - 0.034 14.2 0.0 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Torsin Mg_chelatase PF01078.21 PIK39841.1 - 0.039 13.3 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 PIK39841.1 - 0.05 13.7 0.0 0.096 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 PIK39841.1 - 0.05 14.1 0.0 0.11 13.0 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 PIK39841.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 PIK39841.1 - 0.078 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK39841.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 PIK39841.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 PIK39841.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 PIK39842.1 - 5.1e-19 68.1 0.3 1.1e-18 67.0 0.3 1.6 1 0 0 1 1 1 1 Bromodomain KH_1 PF00013.29 PIK39843.1 - 9.6e-07 28.5 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 KH domain zf-B_box PF00643.24 PIK39844.1 - 2.4e-10 40.4 19.9 9.6e-09 35.3 5.2 3.8 3 1 0 3 3 3 2 B-box zinc finger zf-C3HC4 PF00097.25 PIK39844.1 - 1.1e-08 34.8 7.7 1.1e-08 34.8 7.7 4.4 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK39844.1 - 1.1e-08 34.9 6.7 1.1e-08 34.9 6.7 3.6 4 0 0 4 4 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK39844.1 - 1.7e-07 31.0 4.7 1.7e-07 31.0 4.7 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK39844.1 - 3.3e-07 30.0 8.4 3.3e-07 30.0 8.4 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK39844.1 - 6.7e-07 29.2 7.1 6.7e-07 29.2 7.1 4.7 4 1 0 4 4 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK39844.1 - 6.7e-07 29.4 9.8 6.7e-07 29.4 9.8 4.4 5 0 0 5 5 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK39844.1 - 9.1e-07 29.1 7.2 9.1e-07 29.1 7.2 4.4 4 0 0 4 4 3 1 Ring finger domain Prok-RING_4 PF14447.6 PIK39844.1 - 0.00021 21.1 6.2 0.00021 21.1 6.2 4.3 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 DUF4637 PF15470.6 PIK39844.1 - 0.021 14.6 2.3 0.021 14.6 2.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4637) IBR PF01485.21 PIK39844.1 - 0.029 14.6 2.5 0.029 14.6 2.5 4.9 3 1 0 3 3 2 0 IBR domain, a half RING-finger domain Muted PF14942.6 PIK39844.1 - 0.47 10.8 8.9 2.8 8.3 2.8 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ApoLp-III PF07464.11 PIK39846.1 - 0.013 15.6 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) I_LWEQ PF01608.17 PIK39847.1 - 1.5e-44 151.9 47.7 9.7e-34 116.8 12.8 4.1 2 1 2 4 4 4 4 I/LWEQ domain VBS PF08913.10 PIK39848.1 - 1.9e-24 86.5 1.9 2.3e-24 86.2 1.9 1.1 1 0 0 1 1 1 1 Vinculin Binding Site Herpes_ICP4_N PF03584.15 PIK39848.1 - 0.004 17.0 0.2 0.0047 16.8 0.2 1.2 1 0 0 1 1 1 1 Herpesvirus ICP4-like protein N-terminal region Rotamase PF00639.21 PIK39848.1 - 0.05 14.6 0.3 0.069 14.1 0.3 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain Gp-FAR-1 PF05823.12 PIK39848.1 - 0.075 13.4 0.2 0.11 12.9 0.2 1.3 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) I_LWEQ PF01608.17 PIK39848.1 - 0.13 12.5 4.8 0.18 12.1 4.8 1.2 1 0 0 1 1 1 0 I/LWEQ domain CHDNT PF08073.12 PIK39848.1 - 0.17 11.8 0.0 0.66 10.0 0.0 1.8 2 0 0 2 2 2 0 CHDNT (NUC034) domain NACHT PF05729.12 PIK39850.1 - 1.8e-15 57.2 0.0 3.7e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK39850.1 - 0.00023 20.8 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK39851.1 - 5.6e-08 32.9 0.0 1.4e-07 31.6 0.0 1.6 2 0 0 2 2 2 1 NACHT domain Ubiq_cyt_C_chap PF03981.12 PIK39851.1 - 0.017 15.2 0.3 0.041 14.0 0.0 1.8 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone NACHT PF05729.12 PIK39852.1 - 0.00036 20.5 0.0 0.0005 20.0 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK39852.1 - 0.00055 19.6 0.0 0.0012 18.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain DAP3 PF10236.9 PIK39852.1 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK39852.1 - 0.13 12.6 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Trypsin PF00089.26 PIK39853.1 - 8.7e-13 48.6 0.0 2e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin Lectin_C PF00059.21 PIK39853.1 - 2.4e-07 31.4 0.0 1.1e-06 29.4 0.0 2.1 2 0 0 2 2 2 1 Lectin C-type domain 4HBT PF03061.22 PIK39853.1 - 2.5e-05 24.5 0.1 0.053 13.9 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily DUF1986 PF09342.11 PIK39853.1 - 0.19 12.1 0.9 3.4 8.1 0.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Sulfatase_C PF14707.6 PIK39854.1 - 2.4e-26 92.9 0.4 3.5e-26 92.3 0.4 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK39854.1 - 2.2e-23 83.1 0.0 1e-22 81.0 0.0 1.8 2 0 0 2 2 2 1 Sulfatase Sulfatase PF00884.23 PIK39855.1 - 1e-23 84.2 0.0 1.2e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 Sulfatase EGF PF00008.27 PIK39856.1 - 0.0012 19.1 4.3 0.0012 19.1 4.3 1.9 1 1 1 2 2 2 1 EGF-like domain hEGF PF12661.7 PIK39856.1 - 0.03 15.0 5.5 0.03 15.0 5.5 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK39856.1 - 0.035 14.5 9.9 0.09 13.2 9.9 1.7 1 0 0 1 1 1 0 EGF-like domain Peptidase_S8 PF00082.22 PIK39857.1 - 1e-39 136.6 16.8 2.9e-39 135.1 16.8 1.6 1 1 0 1 1 1 1 Subtilase family Peptidase_S8 PF00082.22 PIK39858.1 - 1.8e-31 109.5 18.7 3e-31 108.8 18.7 1.3 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK39858.1 - 3.5e-07 30.8 0.0 1e-06 29.3 0.0 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 CD225 PF04505.12 PIK39859.1 - 2.6e-24 85.1 0.5 4.1e-24 84.5 0.5 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF2207 PF09972.9 PIK39859.1 - 0.0011 17.9 0.0 0.0013 17.6 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Pox_EPC_I2-L1 PF12575.8 PIK39859.1 - 0.012 15.8 0.1 0.046 14.0 0.0 1.8 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Transposase_28 PF04195.12 PIK39859.1 - 0.028 14.7 0.1 0.047 13.9 0.1 1.3 1 0 0 1 1 1 0 Putative gypsy type transposon FtsX PF02687.21 PIK39859.1 - 0.05 14.1 1.2 0.076 13.5 1.2 1.3 1 0 0 1 1 1 0 FtsX-like permease family SARAF PF06682.12 PIK39859.1 - 0.11 12.2 0.0 7.4 6.1 0.1 2.0 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4134 PF13572.6 PIK39859.1 - 0.19 12.1 2.9 13 6.2 2.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) CD225 PF04505.12 PIK39860.1 - 5e-13 49.0 0.4 7.6e-13 48.4 0.4 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF898 PF05987.13 PIK39860.1 - 0.0051 15.9 0.1 0.0059 15.7 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) DDDD PF10161.9 PIK39860.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Putative mitochondrial precursor protein DUF4602 PF15375.6 PIK39861.1 - 3.7e-13 50.0 9.1 6.4e-13 49.2 9.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) DAPDH_C PF16654.5 PIK39861.1 - 0.0047 16.8 0.0 0.0054 16.6 0.0 1.0 1 0 0 1 1 1 1 Diaminopimelic acid dehydrogenase C-terminal domain VWD PF00094.25 PIK39863.1 - 6.9e-66 221.4 7.0 1.4e-35 122.9 2.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 PIK39863.1 - 9.9e-33 112.4 19.0 8.5e-18 64.5 6.7 5.5 5 1 0 5 5 5 2 C8 domain TIL PF01826.17 PIK39863.1 - 1e-22 80.1 60.9 1.7e-10 40.9 18.5 8.1 7 3 1 8 8 8 3 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 PIK39863.1 - 0.019 15.3 9.5 0.019 15.3 9.5 7.1 4 3 2 6 6 6 0 von Willebrand factor type C domain cEGF PF12662.7 PIK39863.1 - 0.14 12.1 0.1 0.14 12.1 0.1 6.0 6 0 0 6 6 6 0 Complement Clr-like EGF-like 7tm_1 PF00001.21 PIK39864.1 - 1.3e-23 83.7 10.3 1.7e-23 83.3 10.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK39864.1 - 3.8e-07 30.0 11.3 4.8e-07 29.7 11.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK39864.1 - 8.7e-05 22.0 7.7 0.00013 21.5 7.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK39864.1 - 0.00017 21.1 5.2 0.00022 20.7 5.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Frag1 PF10277.9 PIK39864.1 - 0.15 11.6 10.1 2.5 7.6 0.3 2.4 2 1 0 2 2 2 0 Frag1/DRAM/Sfk1 family UPF0542 PF15086.6 PIK39864.1 - 0.17 11.8 0.1 0.17 11.8 0.1 2.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 EGF_2 PF07974.13 PIK39866.1 - 0.076 13.4 13.9 0.12 12.7 13.9 1.3 1 0 0 1 1 1 0 EGF-like domain RHS_repeat PF05593.14 PIK39867.1 - 2.1e-10 40.9 49.5 0.0044 17.5 2.4 11.7 10 3 3 13 13 13 6 RHS Repeat DUF4860 PF16152.5 PIK39867.1 - 0.012 15.5 0.9 0.012 15.5 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4860) DUF5640 PF18692.1 PIK39867.1 - 2.3 8.3 9.9 7.4 6.7 0.0 4.5 3 1 1 4 4 4 0 Family of unknown function (DUF5640) PPC PF04151.15 PIK39868.1 - 0.00063 20.8 0.2 0.0029 18.7 0.2 2.0 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain CARDB PF07705.11 PIK39869.1 - 1.1e-14 54.5 0.8 8.6e-11 42.0 0.4 2.7 3 0 0 3 3 3 2 CARDB AGS_C PF18134.1 PIK39869.1 - 0.048 13.6 0.1 6.4 6.8 0.0 3.0 3 0 0 3 3 3 0 Adenylyl/Guanylyl and SMODS C-terminal sensor domain TEX12 PF15219.6 PIK39871.1 - 0.0045 17.3 0.3 0.0084 16.4 0.3 1.5 1 1 0 1 1 1 1 Testis-expressed 12 CRPV_capsid PF08762.10 PIK39871.1 - 0.056 13.1 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 CRPV capsid protein like Methyltransf_12 PF08242.12 PIK39872.1 - 1e-08 35.8 0.0 1.9e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39872.1 - 3.3e-06 27.7 0.0 7.3e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK39872.1 - 2e-05 24.5 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK39872.1 - 2.2e-05 25.0 0.0 3.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK39872.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39872.1 - 0.02 14.2 0.0 0.068 12.5 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 PIK39872.1 - 0.068 12.4 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family AIRC PF00731.20 PIK39872.1 - 0.13 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 AIR carboxylase Peptidase_M22 PF00814.25 PIK39873.1 - 7.2e-21 75.1 0.0 8.8e-21 74.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Beta-Casp PF10996.8 PIK39873.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Beta-Casp domain Arm PF00514.23 PIK39875.1 - 3e-33 112.8 24.9 2.7e-07 30.4 0.1 10.9 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK39875.1 - 9e-12 45.2 15.7 0.047 14.1 0.6 6.4 4 2 2 7 7 7 6 HEAT repeats Atx10homo_assoc PF09759.9 PIK39875.1 - 3.5e-07 30.2 11.5 0.21 11.6 0.1 6.6 6 2 1 8 8 8 2 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 PIK39875.1 - 0.00089 19.3 19.0 0.31 11.4 0.0 8.2 10 0 0 10 10 10 1 HEAT repeat TM1506 PF08973.10 PIK39875.1 - 0.031 13.9 0.1 4 7.1 0.0 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF1893) Arm_2 PF04826.13 PIK39875.1 - 0.056 12.9 9.1 0.23 10.9 0.5 4.4 2 1 2 4 4 4 0 Armadillo-like HEAT_EZ PF13513.6 PIK39875.1 - 0.28 11.7 15.7 1.4 9.5 0.0 6.2 7 1 1 8 8 8 0 HEAT-like repeat CUB PF00431.20 PIK39876.1 - 5.2e-46 155.5 0.0 2.8e-18 66.3 0.0 3.6 4 0 0 4 4 4 3 CUB domain CUB_2 PF02408.20 PIK39876.1 - 0.023 14.4 0.1 4.2 7.2 0.0 3.2 3 0 0 3 3 3 0 CUB-like domain Amidohydro_1 PF01979.20 PIK39877.1 - 3e-16 59.7 0.6 4.6e-16 59.1 0.6 1.4 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK39877.1 - 4.7e-06 26.4 0.0 1.3e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Amidohydrolase family Motile_Sperm PF00635.26 PIK39877.1 - 0.028 14.3 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Mac-1 PF09028.10 PIK39877.1 - 0.033 13.2 0.0 0.057 12.5 0.0 1.4 1 0 0 1 1 1 0 Mac 1 Actin PF00022.19 PIK39878.1 - 6.4e-120 400.5 0.0 7.8e-120 400.2 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 PIK39878.1 - 5.7e-05 22.1 0.0 0.0099 14.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein MFS_1 PF07690.16 PIK39879.1 - 9.9e-10 37.9 15.7 1.7e-09 37.1 15.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39879.1 - 0.00047 19.1 12.2 0.0006 18.8 12.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter PMT_4TMC PF16192.5 PIK39879.1 - 0.8 9.3 4.3 2.9 7.4 0.2 2.5 2 1 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase DUF3392 PF11872.8 PIK39879.1 - 6.7 7.0 11.4 0.96 9.7 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3392) PDZ PF00595.24 PIK39880.1 - 8e-05 22.9 0.1 0.00013 22.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK39880.1 - 0.0086 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain RNA_bind PF08675.11 PIK39880.1 - 0.088 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain Phage_holin_3_6 PF07332.11 PIK39880.1 - 4.6 7.3 9.9 21 5.2 3.4 2.2 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III MFS_1 PF07690.16 PIK39881.1 - 7.9e-08 31.6 20.3 1.1e-07 31.1 19.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39881.1 - 0.00031 19.8 12.1 0.00039 19.4 12.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF3392 PF11872.8 PIK39881.1 - 0.91 9.8 0.1 0.91 9.8 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3392) PDZ PF00595.24 PIK39882.1 - 4.3e-62 206.4 10.3 2e-16 60.1 0.1 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK39882.1 - 8.5e-29 99.2 4.7 5.4e-08 32.6 0.1 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK39882.1 - 1.6e-22 79.6 3.3 1.8e-05 25.0 0.0 4.3 4 0 0 4 4 4 4 PDZ domain zf-RING_UBOX PF13445.6 PIK39882.1 - 3.7e-07 30.1 4.6 1.4e-06 28.2 4.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK39882.1 - 8.4e-07 28.7 7.4 8.4e-07 28.7 7.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK39882.1 - 2.3e-06 27.6 7.0 6.7e-06 26.2 7.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.18 PIK39882.1 - 3.8e-06 27.5 3.5 1.1e-05 26.0 3.5 1.8 1 0 0 1 1 1 1 TRAF-type zinc finger zf-C3HC4 PF00097.25 PIK39882.1 - 6.4e-06 25.9 6.8 6.4e-06 25.9 6.8 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK39882.1 - 7.4e-06 25.8 5.0 7.4e-06 25.8 5.0 2.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK39882.1 - 4e-05 23.9 5.2 4e-05 23.9 5.2 2.6 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK39882.1 - 0.00017 21.4 4.8 0.00017 21.4 4.8 2.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK39882.1 - 0.0024 18.1 2.6 0.0024 18.1 2.6 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain Sina PF03145.16 PIK39882.1 - 0.057 13.4 4.3 0.098 12.6 4.3 1.3 1 0 0 1 1 1 0 Seven in absentia protein family zf-RING_10 PF16685.5 PIK39882.1 - 2.1 8.5 11.5 0.06 13.5 4.8 1.9 2 1 0 2 2 1 0 zinc RING finger of MSL2 zf-TRAF_2 PF15965.5 PIK39882.1 - 5.8 7.5 13.4 0.12 12.8 5.8 1.9 1 1 1 2 2 2 0 TRAF-like zinc-finger Prok-RING_4 PF14447.6 PIK39882.1 - 8.9 6.3 10.4 0.99 9.3 5.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Pkinase_Tyr PF07714.17 PIK39883.1 - 5.5e-29 101.2 0.0 8e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK39883.1 - 1.6e-21 76.9 0.0 2.8e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK39883.1 - 2.2e-13 50.6 3.7 4.3e-06 27.2 0.2 3.7 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK39883.1 - 8.7e-10 38.5 1.5 0.0001 22.3 0.1 4.3 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK39883.1 - 3e-09 36.8 0.1 0.00011 22.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK39883.1 - 6.1e-07 29.7 5.4 0.001 19.4 0.3 3.9 3 1 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK39883.1 - 3.6e-06 27.1 1.3 0.0011 19.1 0.1 3.6 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK39883.1 - 0.00015 21.9 1.9 0.011 15.9 0.4 3.5 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK39883.1 - 0.084 12.5 0.3 0.54 9.9 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Transp_Tc5_C PF04236.15 PIK39885.1 - 0.0095 16.3 1.6 0.0095 16.3 1.6 2.3 2 0 0 2 2 2 1 Tc5 transposase C-terminal domain rve PF00665.26 PIK39886.1 - 2.3e-22 79.4 0.0 6.2e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK39886.1 - 5.9e-22 78.3 0.0 1.1e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK39886.1 - 0.00039 20.1 0.0 0.0014 18.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK39886.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 DDE domain Ig_3 PF13927.6 PIK39887.1 - 0.00053 20.5 8.5 1.2 9.8 0.1 4.1 2 2 2 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK39887.1 - 0.0019 18.2 0.8 0.35 11.0 0.2 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Calycin_like PF13944.6 PIK39887.1 - 0.011 16.0 0.1 0.14 12.5 0.1 2.4 2 1 0 2 2 2 0 Calycin-like beta-barrel domain Marek_A PF02124.15 PIK39887.1 - 0.032 14.1 0.5 0.099 12.5 0.2 1.8 2 0 0 2 2 2 0 Marek's disease glycoprotein A A2M_recep PF07677.14 PIK39889.1 - 2.4e-21 76.2 0.1 6.1e-21 74.9 0.1 1.7 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain TED_complement PF07678.14 PIK39889.1 - 9.2e-17 61.0 0.1 1.3e-16 60.5 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain NTR PF01759.21 PIK39889.1 - 2.8e-10 40.0 0.0 6.1e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module MG1 PF17790.1 PIK39890.1 - 9.1e-06 26.0 0.1 1.7e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Macroglobulin domain MG1 MG2 PF01835.19 PIK39890.1 - 0.00044 20.6 0.1 1.3 9.5 0.0 2.2 2 0 0 2 2 2 2 MG2 domain Serpin PF00079.20 PIK39891.1 - 1.7e-98 330.4 0.3 2e-98 330.2 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF659 PF04937.15 PIK39892.1 - 0.0091 15.9 0.3 0.08 12.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) OST-HTH PF12872.7 PIK39893.1 - 6.3e-11 41.9 0.1 1.3e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 OST-HTH/LOTUS domain RRM_1 PF00076.22 PIK39893.1 - 0.0051 16.6 0.1 0.0097 15.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 PIK39895.1 - 2.2e-06 26.8 36.1 0.007 15.3 1.7 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK39895.1 - 0.0097 14.8 1.1 0.0097 14.8 1.1 2.9 2 1 0 2 2 2 2 Sugar (and other) transporter 7tm_1 PF00001.21 PIK39897.1 - 2.8e-32 112.1 1.6 3.8e-32 111.6 1.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK39897.1 - 1.2e-08 34.7 1.7 2.1e-07 30.6 0.2 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK39897.1 - 2.6e-07 30.3 3.4 1.2e-06 28.2 3.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK39897.1 - 0.00022 21.0 2.8 0.00022 21.0 2.8 2.4 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK39897.1 - 0.0041 16.7 1.7 0.0041 16.7 1.7 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc GWT1 PF06423.12 PIK39897.1 - 1.7 8.7 4.9 11 6.1 0.4 2.8 1 1 2 3 3 3 0 GWT1 dCache_1 PF02743.18 PIK39898.1 - 0.0027 17.5 0.1 0.0076 16.1 0.1 1.6 2 0 0 2 2 2 1 Cache domain VWA_N PF08399.11 PIK39898.1 - 0.031 14.8 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 VWA N-terminal Fz PF01392.22 PIK39899.1 - 2.2e-29 102.3 3.6 3.7e-29 101.6 3.6 1.4 1 0 0 1 1 1 1 Fz domain NTR PF01759.21 PIK39899.1 - 4.9e-12 45.6 0.1 7.9e-12 44.9 0.1 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Bacillus_HBL PF05791.11 PIK39900.1 - 0.013 15.4 0.2 0.016 15.1 0.2 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DCX PF03607.17 PIK39901.1 - 4.6e-33 113.1 0.1 4.6e-19 68.3 0.0 2.3 2 0 0 2 2 2 2 Doublecortin DUF4577 PF15145.6 PIK39901.1 - 0.0048 16.9 0.1 0.011 15.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4577) KHA PF11834.8 PIK39901.1 - 0.02 15.0 0.0 0.32 11.1 0.0 2.3 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel PLAT PF01477.23 PIK39902.1 - 7.6e-25 87.8 1.1 5.8e-14 52.7 0.4 2.1 2 0 0 2 2 2 2 PLAT/LH2 domain ATS3 PF06232.11 PIK39902.1 - 0.15 12.0 0.0 3.9 7.4 0.0 2.1 2 0 0 2 2 2 0 Embryo-specific protein 3, (ATS3) fn3 PF00041.21 PIK39903.1 - 4.9e-38 129.4 2.5 1.5e-10 41.3 0.0 4.1 4 0 0 4 4 4 4 Fibronectin type III domain Glyco_hydro_66 PF13199.6 PIK39903.1 - 3.7e-06 25.9 1.2 0.0091 14.7 0.1 3.4 4 0 0 4 4 4 2 Glycosyl hydrolase family 66 DUF4959 PF16323.5 PIK39903.1 - 0.00047 20.4 2.0 0.12 12.7 0.1 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4959) Pur_ac_phosph_N PF16656.5 PIK39903.1 - 0.0028 18.2 4.3 0.035 14.7 0.1 3.6 3 2 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Arylsulfotran_N PF17425.2 PIK39903.1 - 0.092 12.8 1.7 0.24 11.5 0.3 2.4 2 0 0 2 2 2 0 Arylsulfotransferase Ig-like domain PrcB_C PF14343.6 PIK39903.1 - 0.13 12.4 1.2 0.39 10.9 0.2 2.3 2 0 0 2 2 2 0 PrcB C-terminal TQ PF18202.1 PIK39903.1 - 0.23 12.0 6.4 0.14 12.6 2.9 2.2 1 1 1 2 2 2 0 T-Q ester bond containing domain fn3 PF00041.21 PIK39904.1 - 3.9e-12 46.4 0.0 2.1e-09 37.6 0.1 2.1 2 0 0 2 2 2 2 Fibronectin type III domain fn3 PF00041.21 PIK39905.1 - 7e-17 61.6 12.0 0.00028 21.1 0.1 6.9 6 1 0 6 6 6 5 Fibronectin type III domain PLAT PF01477.23 PIK39905.1 - 8.9e-07 29.5 2.1 3.9e-06 27.4 0.2 2.9 3 0 0 3 3 3 1 PLAT/LH2 domain Pur_ac_phosph_N PF16656.5 PIK39905.1 - 3.4e-06 27.5 13.9 0.78 10.4 0.5 5.9 4 1 0 4 4 4 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK39905.1 - 0.005 17.2 0.0 1.1 9.7 0.0 3.9 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Dmrt1 PF12374.8 PIK39905.1 - 0.17 12.3 1.4 0.52 10.8 0.3 2.4 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 Fibrinogen_C PF00147.18 PIK39906.1 - 1.7e-40 139.1 0.7 2.1e-40 138.9 0.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK39906.1 - 4e-06 27.0 19.4 4e-06 27.0 19.4 2.0 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK39907.1 - 3.6e-66 223.1 9.2 4.2e-66 222.9 9.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK39907.1 - 6.2e-05 23.1 7.5 6.2e-05 23.1 7.5 2.3 3 0 0 3 3 3 1 EGF domain COLFI PF01410.18 PIK39907.1 - 0.00094 18.5 0.2 0.0015 17.9 0.2 1.3 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain EGF_MSP1_1 PF12946.7 PIK39907.1 - 0.25 11.4 4.2 0.63 10.1 4.2 1.7 1 0 0 1 1 1 0 MSP1 EGF domain 1 GLEYA PF10528.9 PIK39907.1 - 0.88 10.0 4.5 2.3 8.7 1.6 2.5 2 1 0 2 2 2 0 GLEYA domain Fibrinogen_C PF00147.18 PIK39908.1 - 1.5e-68 230.9 12.3 1.4e-66 224.5 9.0 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK39908.1 - 2.4e-06 27.7 19.7 2.4e-06 27.7 19.7 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK39908.1 - 0.00015 21.7 5.2 0.00015 21.7 5.2 3.5 3 1 1 4 4 4 2 TILa domain EGF_3 PF12947.7 PIK39908.1 - 0.0003 20.9 6.6 0.0003 20.9 6.6 3.5 3 0 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK39909.1 - 4.4e-26 92.1 0.8 5e-26 91.9 0.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK39909.1 - 1.3e-06 28.5 19.0 2.3e-06 27.7 19.0 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK39910.1 - 1.1e-66 224.9 9.0 1.2e-66 224.7 9.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK39910.1 - 0.0027 17.1 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Fibrinogen_C PF00147.18 PIK39911.1 - 1.1e-39 136.6 6.2 2.1e-28 99.6 3.5 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK39911.1 - 5e-05 23.4 6.8 5e-05 23.4 6.8 2.6 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK39911.1 - 0.00011 22.0 2.5 0.00011 22.0 2.5 2.4 2 0 0 2 2 2 1 TILa domain COLFI PF01410.18 PIK39911.1 - 0.00029 20.2 0.8 0.00029 20.2 0.8 2.1 1 1 1 2 2 2 1 Fibrillar collagen C-terminal domain EGF_Tenascin PF18720.1 PIK39911.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.8 1 1 1 2 2 2 0 Tenascin EGF domain Tme5_EGF_like PF09064.10 PIK39911.1 - 3.9 7.5 7.4 2.8 7.9 4.4 2.3 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like FH2 PF02181.23 PIK39912.1 - 2e-79 267.4 24.7 2e-79 267.4 24.7 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 PIK39912.1 - 1.3e-45 155.4 0.6 1.3e-45 155.4 0.6 4.2 5 0 0 5 5 5 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 PIK39912.1 - 1.7e-39 135.4 0.0 1.7e-39 135.4 0.0 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_DAD PF06345.11 PIK39912.1 - 1.5e-07 30.9 0.8 3.4e-07 29.8 0.8 1.6 1 0 0 1 1 1 1 DRF Autoregulatory Domain DUF3361 PF11841.8 PIK39912.1 - 0.011 15.6 0.1 2.8 7.8 0.0 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) RcbX PF02341.15 PIK39912.1 - 0.84 9.9 12.4 0.41 10.9 0.5 3.9 4 0 0 4 4 4 0 RbcX protein LMBR1 PF04791.16 PIK39912.1 - 2.6 6.8 6.5 3 6.6 0.1 2.5 2 0 0 2 2 2 0 LMBR1-like membrane protein Glyco_transf_41 PF13844.6 PIK39913.1 - 9e-239 792.6 0.0 1.2e-238 792.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.28 PIK39913.1 - 2.8e-94 305.5 19.7 9.1e-10 37.9 0.4 12.4 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_11 PF13414.6 PIK39913.1 - 3.3e-87 285.9 27.0 4.7e-11 42.2 0.5 12.5 2 2 10 12 12 12 12 TPR repeat TPR_2 PF07719.17 PIK39913.1 - 3e-69 223.6 17.4 3e-07 30.1 0.1 12.1 12 0 0 12 12 11 11 Tetratricopeptide repeat TPR_8 PF13181.6 PIK39913.1 - 1.5e-62 202.6 8.3 4.3e-06 26.5 0.1 12.9 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_17 PF13431.6 PIK39913.1 - 4.1e-62 202.2 29.9 1.4e-06 28.3 0.1 13.5 14 0 0 14 14 12 11 Tetratricopeptide repeat TPR_12 PF13424.6 PIK39913.1 - 7.9e-46 154.2 23.1 8.9e-10 38.7 0.2 9.1 4 2 5 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.6 PIK39913.1 - 1e-41 141.3 7.4 4e-07 30.6 0.0 6.8 5 1 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 PIK39913.1 - 6.4e-40 132.3 8.0 0.0049 16.8 0.1 12.2 12 1 1 13 13 13 8 Tetratricopeptide repeat TPR_14 PF13428.6 PIK39913.1 - 1.5e-39 131.3 8.3 0.00052 20.6 0.0 11.1 5 4 6 11 11 11 9 Tetratricopeptide repeat TPR_19 PF14559.6 PIK39913.1 - 5.5e-36 122.9 20.4 2.4e-06 28.0 0.1 9.0 4 4 5 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 PIK39913.1 - 1.1e-32 110.9 35.9 0.00021 21.0 0.4 11.1 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_9 PF13371.6 PIK39913.1 - 5.1e-17 61.8 6.1 0.0019 18.3 0.3 6.4 4 2 3 7 7 7 5 Tetratricopeptide repeat NARP1 PF12569.8 PIK39913.1 - 3.3e-15 56.0 2.7 0.0041 16.1 0.0 5.4 2 2 5 7 7 7 4 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 PIK39913.1 - 4.9e-13 48.8 12.2 0.83 10.4 0.0 10.2 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_4 PF07721.14 PIK39913.1 - 4.1e-12 45.5 0.7 1.5 9.7 0.2 8.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK39913.1 - 1.3e-09 37.7 1.9 0.00016 21.0 0.2 4.4 2 2 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK39913.1 - 2.5e-09 37.0 8.7 0.0019 17.6 0.3 5.4 2 2 2 4 4 4 2 MalT-like TPR region FAT PF02259.23 PIK39913.1 - 3e-08 33.3 0.0 0.46 9.7 0.1 5.7 2 2 2 4 4 4 1 FAT domain MIT PF04212.18 PIK39913.1 - 3.7e-07 30.1 18.1 2 8.6 0.0 8.3 6 1 2 8 8 8 2 MIT (microtubule interacting and transport) domain EST1_DNA_bind PF10373.9 PIK39913.1 - 6.2e-07 29.2 10.3 0.06 12.8 0.3 5.2 4 1 0 5 5 5 2 Est1 DNA/RNA binding domain TPR_3 PF07720.12 PIK39913.1 - 3.4e-05 23.7 2.4 1.3 9.1 0.0 5.2 6 0 0 6 6 5 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK39913.1 - 0.00011 21.6 0.4 0.3 10.6 0.0 4.8 6 0 0 6 6 5 1 SHNi-TPR BTAD PF03704.17 PIK39913.1 - 0.00022 21.7 11.2 0.93 9.9 0.2 5.6 4 2 3 7 7 6 2 Bacterial transcriptional activator domain Wzy_C_2 PF11846.8 PIK39913.1 - 0.00036 20.5 4.9 2.6 8.0 0.1 4.6 3 1 3 6 6 6 1 Virulence factor membrane-bound polymerase, C-terminal TPR_21 PF09976.9 PIK39913.1 - 0.00088 19.0 9.6 1.1 9.0 0.6 5.1 2 2 1 4 4 4 1 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 PIK39913.1 - 0.0059 16.9 8.9 2.9 8.3 0.1 5.5 4 1 0 5 5 5 1 Tetratricopeptide repeat SNAP PF14938.6 PIK39913.1 - 0.0061 16.0 13.7 1.1 8.6 4.1 4.7 1 1 2 4 4 4 2 Soluble NSF attachment protein, SNAP Mad3_BUB1_I PF08311.12 PIK39913.1 - 0.023 14.7 5.5 15 5.5 0.0 5.4 5 1 1 6 6 6 0 Mad3/BUB1 homology region 1 ANAPC3 PF12895.7 PIK39913.1 - 0.045 14.0 0.5 0.045 14.0 0.5 4.6 3 1 3 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 PIK39913.1 - 0.15 11.8 0.3 37 4.0 0.0 3.5 3 2 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 PPR PF01535.20 PIK39913.1 - 0.22 11.8 2.9 39 4.8 0.0 5.4 7 0 0 7 7 4 0 PPR repeat DUF627 PF04781.12 PIK39913.1 - 0.88 9.6 3.6 25 4.9 0.4 4.2 2 1 0 3 3 3 0 Protein of unknown function (DUF627) WD40 PF00400.32 PIK39914.1 - 1.2e-46 155.7 28.3 1.6e-06 28.7 0.1 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat HHH_3 PF12836.7 PIK39914.1 - 2.4e-15 56.5 0.1 4.2e-15 55.7 0.1 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif ANAPC4_WD40 PF12894.7 PIK39914.1 - 1.1e-11 44.8 6.0 0.17 12.2 0.1 6.4 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK39914.1 - 1.4e-11 43.8 11.6 0.058 12.0 0.1 6.3 3 2 4 7 7 7 5 Nucleoporin Nup120/160 F-box-like PF12937.7 PIK39914.1 - 8.4e-11 41.6 2.4 1.6e-10 40.7 2.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK39914.1 - 2.7e-09 36.7 1.5 5.8e-09 35.6 1.5 1.6 1 0 0 1 1 1 1 F-box domain HHH PF00633.23 PIK39914.1 - 5.5e-06 26.0 0.0 0.012 15.5 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif PQQ_2 PF13360.6 PIK39914.1 - 6.1e-05 22.7 2.9 0.00019 21.1 2.9 1.9 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.5 PIK39914.1 - 0.00014 20.9 7.0 0.48 9.3 0.2 4.6 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK39914.1 - 0.0017 17.8 0.1 0.01 15.2 0.0 1.9 1 1 0 1 1 1 1 WD40-like domain HHH_5 PF14520.6 PIK39914.1 - 0.0043 17.6 0.3 0.34 11.5 0.1 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain CDtoxinA PF03498.14 PIK39914.1 - 0.011 15.3 0.2 1.8 8.1 0.0 3.3 2 1 2 4 4 4 0 Cytolethal distending toxin A/C domain AsnC_trans_reg PF01037.21 PIK39914.1 - 0.1 12.6 0.0 3 7.9 0.0 3.3 3 0 0 3 3 3 0 Lrp/AsnC ligand binding domain HRDC PF00570.23 PIK39914.1 - 0.1 12.6 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 HRDC domain SR-25 PF10500.9 PIK39914.1 - 0.39 10.3 16.6 0.59 9.7 16.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Alpha-amylase_C PF02806.18 PIK39916.1 - 3.5e-12 46.6 0.1 1.1e-11 45.0 0.1 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 PIK39916.1 - 1.5e-08 34.6 0.1 0.001 18.7 0.0 2.2 1 1 1 2 2 2 2 Alpha amylase, catalytic domain RNA_pol_I_A49 PF06870.12 PIK39917.1 - 2e-40 138.8 1.5 2.7e-40 138.4 1.5 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Mod_r PF07200.13 PIK39918.1 - 0.014 15.5 0.7 0.021 15.0 0.7 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Acetyltransf_1 PF00583.25 PIK39919.1 - 2.2e-06 27.9 0.0 3.3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 PIK39919.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein PI3Ka PF00613.20 PIK39919.1 - 0.025 14.0 0.2 0.025 14.0 0.2 1.6 2 0 0 2 2 2 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Acetyltransf_7 PF13508.7 PIK39919.1 - 0.062 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PHD PF00628.29 PIK39920.1 - 5.2e-08 32.6 5.6 5.2e-08 32.6 5.6 3.3 4 0 0 4 4 4 1 PHD-finger UCH_1 PF13423.6 PIK39920.1 - 2.3e-07 30.7 0.2 4.5e-07 29.8 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 PIK39920.1 - 8.7e-06 25.4 0.0 3.1e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 PIK39920.1 - 0.035 13.6 1.7 0.35 10.3 1.7 2.6 1 1 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase PHD_2 PF13831.6 PIK39920.1 - 0.41 10.2 9.4 0.044 13.3 1.2 3.1 3 0 0 3 3 3 0 PHD-finger PHD_4 PF16866.5 PIK39920.1 - 4.7 7.4 11.7 0.8 9.8 2.7 2.9 2 1 0 2 2 2 0 PHD-finger zf-FPG_IleRS PF06827.14 PIK39920.1 - 5.8 6.9 9.5 3.5 7.6 0.1 3.5 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS zinc_ribbon_2 PF13240.6 PIK39920.1 - 7.2 6.5 7.4 14 5.5 0.1 3.7 4 0 0 4 4 4 0 zinc-ribbon domain TUTF7_u4 PF16631.5 PIK39921.1 - 0.013 16.1 7.9 0.013 16.1 7.9 4.3 1 1 3 4 4 4 0 Unstructured region 4 on terminal uridylyltransferase 7 SRCR PF00530.18 PIK39923.1 - 6.3e-129 421.3 13.4 3e-29 101.5 0.2 5.0 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK39923.1 - 2.6e-31 108.0 20.0 3.2e-06 27.6 0.2 5.7 6 0 0 6 6 6 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK39923.1 - 1.9e-18 66.9 0.1 0.023 15.2 0.0 5.5 5 0 0 5 5 5 5 Hepsin, SRCR domain PT PF04886.12 PIK39923.1 - 0.064 12.8 2.0 1.8 8.1 2.0 2.9 1 1 0 1 1 1 0 PT repeat CD20 PF04103.15 PIK39924.1 - 0.00015 21.9 15.8 0.00041 20.5 15.7 1.7 1 1 0 1 1 1 1 CD20-like family Ost5 PF05251.12 PIK39924.1 - 0.5 10.7 6.9 0.24 11.7 0.8 2.6 2 1 0 2 2 2 0 Oligosaccharyltransferase subunit 5 TMEM169 PF15052.6 PIK39924.1 - 2.4 8.3 8.5 0.37 10.9 3.8 1.7 1 1 1 2 2 2 0 TMEM169 protein family 7tm_1 PF00001.21 PIK39925.1 - 5.6e-33 114.4 4.0 6.8e-33 114.1 4.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK39925.1 - 2.1e-11 43.7 1.2 2.9e-11 43.2 1.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK39925.1 - 2.1e-09 37.2 0.6 2.8e-09 36.8 0.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK39925.1 - 3.4e-05 23.6 3.2 3.8e-05 23.4 0.2 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK39925.1 - 0.00015 21.6 0.4 0.00063 19.6 0.4 2.1 1 1 0 1 1 1 1 Olfactory receptor Ni_hydr_CYTB PF01292.20 PIK39925.1 - 0.0027 17.3 0.6 0.0051 16.4 0.6 1.5 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 7tm_7 PF08395.12 PIK39925.1 - 0.029 13.6 1.8 0.3 10.2 0.1 2.0 2 0 0 2 2 2 0 7tm Chemosensory receptor DUF5136 PF17199.4 PIK39925.1 - 0.13 12.0 1.9 1.2 8.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5136) Mei4 PF13971.6 PIK39926.1 - 6.9e-16 58.7 8.7 1.2e-15 57.9 8.7 1.2 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 7tm_1 PF00001.21 PIK39927.1 - 4.1e-32 111.6 15.7 6.2e-32 111.0 15.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK39927.1 - 1.2e-15 57.0 0.9 3.4e-10 39.5 1.0 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 PIK39927.1 - 1.5e-05 25.0 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK39927.1 - 0.051 13.1 0.2 0.096 12.2 0.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_4 PF12799.7 PIK39927.1 - 0.46 11.0 1.9 3 8.4 1.0 2.4 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) 7tm_4 PF13853.6 PIK39927.1 - 1.2 8.8 15.7 14 5.3 15.7 2.1 1 1 0 1 1 1 0 Olfactory receptor ERAP1_C PF11838.8 PIK39928.1 - 1.3e-52 179.4 0.2 1.4e-52 179.2 0.2 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain PTCB-BRCT PF12738.7 PIK39929.1 - 4.5e-14 52.1 0.3 1.1e-13 51.0 0.3 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 PIK39929.1 - 5.9e-05 23.4 0.1 5.9e-05 23.4 0.1 2.4 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK39929.1 - 8.8e-05 22.8 0.6 0.00027 21.3 0.1 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain HRDC PF00570.23 PIK39929.1 - 0.17 11.9 4.6 18 5.4 0.1 4.5 2 1 3 5 5 5 0 HRDC domain BRCT_2 PF16589.5 PIK39930.1 - 8.4e-07 29.3 0.0 0.0033 17.8 0.0 2.2 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK39930.1 - 0.0023 18.3 0.0 0.56 10.6 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RRM_1 PF00076.22 PIK39932.1 - 2.1e-26 91.5 0.0 5.2e-16 58.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trnau1ap PF17654.1 PIK39932.1 - 1.4e-12 48.3 27.4 8.7e-12 45.8 27.4 2.1 1 1 0 1 1 1 1 Selenocysteine tRNA 1 associated proteins BRAP2 PF07576.12 PIK39932.1 - 0.012 15.9 0.0 0.3 11.3 0.0 2.4 2 0 0 2 2 2 0 BRCA1-associated protein 2 Limkain-b1 PF11608.8 PIK39932.1 - 0.051 13.7 0.0 5.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 RRM_7 PF16367.5 PIK39932.1 - 0.065 13.4 0.1 13 6.0 0.0 3.0 3 0 0 3 3 3 0 RNA recognition motif Fibrinogen_C PF00147.18 PIK39933.1 - 6.8e-58 196.1 8.4 8.6e-58 195.7 8.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK39934.1 - 1.8e-64 217.6 7.2 2.1e-64 217.3 7.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK39935.1 - 9.6e-81 270.8 4.8 2.5e-41 141.9 1.4 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK39935.1 - 1.3e-09 37.9 5.8 1.3e-09 37.9 5.8 3.4 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK39935.1 - 3.7e-05 23.8 12.0 3.7e-05 23.8 12.0 4.1 3 2 1 4 4 4 1 EGF domain TIL PF01826.17 PIK39935.1 - 0.0023 18.1 19.7 0.0023 18.1 19.7 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain SPOR PF05036.13 PIK39935.1 - 0.18 12.2 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 Sporulation related domain Fibrinogen_C PF00147.18 PIK39936.1 - 1.6e-25 90.3 0.9 2.1e-25 89.9 0.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK39937.1 - 7.3e-47 160.0 2.2 6.5e-38 130.7 0.5 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK39937.1 - 4.2e-09 36.2 7.2 4.2e-09 36.2 7.2 2.9 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK39937.1 - 3.1e-07 30.5 33.7 4.2e-06 26.8 9.5 3.8 2 1 1 3 3 3 2 EGF domain TIL PF01826.17 PIK39937.1 - 0.024 14.9 12.2 0.024 14.9 12.2 3.6 2 1 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 PIK39937.1 - 0.063 13.2 0.7 0.063 13.2 0.7 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK39937.1 - 4.9 7.3 24.4 0.26 11.4 4.6 3.0 3 0 0 3 3 3 0 MSP1 EGF domain 1 hEGF PF12661.7 PIK39937.1 - 6.3 7.6 22.2 0.39 11.4 1.3 4.8 3 1 2 5 5 5 0 Human growth factor-like EGF Fibrinogen_C PF00147.18 PIK39938.1 - 1.3e-17 64.3 3.5 3.9e-06 26.8 0.1 3.4 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK39938.1 - 1e-10 41.4 7.3 1e-10 41.4 7.3 3.7 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK39938.1 - 6.9e-06 26.2 10.5 6.9e-06 26.2 10.5 4.7 3 2 1 4 4 4 1 EGF domain TIL PF01826.17 PIK39938.1 - 0.00088 19.5 18.7 0.00088 19.5 18.7 3.4 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 PIK39938.1 - 0.0052 16.7 1.0 0.0052 16.7 1.0 5.2 6 0 0 6 6 6 2 Complement Clr-like EGF-like Ephrin_rec_like PF07699.13 PIK39939.1 - 0.00022 20.9 37.2 0.002 17.9 7.2 5.7 2 2 3 5 5 5 3 Putative ephrin-receptor like LRR_8 PF13855.6 PIK39940.1 - 1.6e-13 50.2 7.9 1.1e-08 34.8 5.5 2.4 1 1 1 2 2 2 2 Leucine rich repeat Ephrin_rec_like PF07699.13 PIK39940.1 - 2.9e-08 33.3 25.3 2.9e-07 30.2 7.9 4.0 1 1 4 5 5 5 4 Putative ephrin-receptor like LRR_5 PF13306.6 PIK39940.1 - 6.2e-05 23.0 0.0 0.00023 21.1 0.0 1.9 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK39940.1 - 0.0053 17.1 9.7 0.17 12.4 3.0 3.5 1 1 3 4 4 4 2 Leucine Rich repeats (2 copies) TNFR_c6 PF00020.18 PIK39940.1 - 0.11 12.9 0.8 0.11 12.9 0.8 4.3 2 1 2 4 4 4 0 TNFR/NGFR cysteine-rich region LRR_9 PF14580.6 PIK39940.1 - 0.12 11.8 0.4 0.18 11.3 0.4 1.2 1 0 0 1 1 1 0 Leucine-rich repeat DUF1041 PF06292.17 PIK39941.1 - 3.4e-34 117.4 1.4 7.2e-34 116.4 1.4 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.29 PIK39941.1 - 2.2e-07 31.3 0.2 1.2e-06 29.0 0.2 2.2 1 1 0 1 1 1 1 PH domain NUDIX PF00293.28 PIK39941.1 - 0.022 14.8 0.8 0.056 13.5 0.8 1.6 1 0 0 1 1 1 0 NUDIX domain DapB_N PF01113.20 PIK39941.1 - 0.18 11.9 0.1 0.47 10.6 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF2620 PF10941.8 PIK39942.1 - 0.14 12.3 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2620 60KD_IMP PF02096.20 PIK39943.1 - 0.026 14.4 0.2 0.037 13.9 0.2 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein Kinetochor_Ybp2 PF08568.10 PIK39943.1 - 0.098 11.1 0.2 0.12 10.8 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin RVT_1 PF00078.27 PIK39944.1 - 1.9e-07 30.8 0.0 3.8e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DTW PF03942.15 PIK39945.1 - 2.7e-28 99.1 0.1 1.6e-27 96.5 0.0 1.8 1 1 1 2 2 2 1 DTW domain Pox_E10 PF04805.12 PIK39945.1 - 0.61 10.0 10.3 2.1 8.3 1.6 2.5 1 1 1 2 2 2 0 E10-like protein conserved region STT3 PF02516.14 PIK39946.1 - 2.9e-152 508.0 44.1 2.7e-147 491.6 39.5 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 PIK39946.1 - 0.00034 20.9 13.0 0.00034 20.9 13.0 2.9 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase fn3 PF00041.21 PIK39947.1 - 1.4e-06 28.5 0.6 3.7e-06 27.2 0.6 1.7 1 0 0 1 1 1 1 Fibronectin type III domain TSR PF18487.1 PIK39947.1 - 0.052 13.8 0.6 0.15 12.3 0.6 1.7 1 0 0 1 1 1 0 Thrombospondin type 1 repeat 4HB_MCP_1 PF12729.7 PIK39948.1 - 0.87 9.1 2.2 1.4 8.4 2.2 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction CoxIIa PF08113.11 PIK39948.1 - 2 8.3 7.5 3.8 7.4 7.5 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family DUF4845 PF16137.5 PIK39949.1 - 0.0084 16.9 0.2 0.013 16.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4845) BRICHOS PF04089.14 PIK39949.1 - 0.013 15.7 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 BRICHOS domain DUF4179 PF13786.6 PIK39949.1 - 0.015 15.7 0.9 0.028 14.9 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) BRICHOS PF04089.14 PIK39950.1 - 0.014 15.6 0.0 0.044 14.0 0.0 1.9 1 1 0 1 1 1 0 BRICHOS domain CoxIIa PF08113.11 PIK39950.1 - 0.33 10.8 9.0 0.6 10.0 9.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family Pre-PUA PF17832.1 PIK39951.1 - 3.5e-25 88.5 0.0 8.3e-25 87.3 0.0 1.7 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 PIK39951.1 - 0.00043 20.2 0.0 0.00081 19.3 0.0 1.4 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 PIK39951.1 - 0.0049 17.1 0.5 0.015 15.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1947) DUF2188 PF09954.9 PIK39951.1 - 0.063 13.4 0.1 0.2 11.8 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Sugarporin_N PF11471.8 PIK39951.1 - 0.62 10.1 7.0 1.2 9.2 7.0 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension SUI1 PF01253.22 PIK39952.1 - 1.1e-19 70.7 0.1 1.6e-19 70.2 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.18 PIK39952.1 - 0.00025 20.9 0.0 0.00043 20.1 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain PRP38 PF03371.15 PIK39953.1 - 1.3e-45 155.4 0.4 1.9e-45 154.9 0.4 1.2 1 0 0 1 1 1 1 PRP38 family CDC45 PF02724.14 PIK39953.1 - 0.013 13.8 4.5 0.015 13.6 4.5 1.3 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.7 PIK39953.1 - 0.024 15.3 23.8 0.024 15.3 23.8 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term LAP1C PF05609.12 PIK39953.1 - 0.12 11.5 5.5 0.15 11.1 5.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Coilin_N PF15862.5 PIK39953.1 - 1.2 8.9 11.6 0.68 9.7 8.6 2.0 2 0 0 2 2 2 0 Coilin N-terminus Presenilin PF01080.17 PIK39953.1 - 1.5 7.5 3.9 1.7 7.3 3.9 1.2 1 0 0 1 1 1 0 Presenilin AAA PF00004.29 PIK39954.1 - 2.7e-18 66.7 0.0 7e-18 65.3 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK39954.1 - 2.5e-11 44.3 0.0 3.6e-10 40.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 PIK39954.1 - 3.2e-11 43.2 1.5 7e-11 42.1 0.1 2.1 2 0 0 2 2 2 1 AAA lid domain AAA_22 PF13401.6 PIK39954.1 - 2.2e-09 37.7 0.0 6.8e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.11 PIK39954.1 - 9.1e-09 35.2 0.0 2.9e-08 33.6 0.0 1.9 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain DUF2075 PF09848.9 PIK39954.1 - 0.00095 18.5 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 PIK39954.1 - 0.0088 16.4 0.1 0.025 14.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK39954.1 - 0.011 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 PIK39954.1 - 0.031 14.0 0.1 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Phage_cap_E PF03864.15 PIK39954.1 - 0.079 12.1 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Phage major capsid protein E Aurora-A_bind PF09041.10 PIK39954.1 - 0.092 12.8 0.5 0.23 11.6 0.5 1.6 1 0 0 1 1 1 0 Aurora-A binding T2SSE PF00437.20 PIK39954.1 - 0.11 11.6 0.4 0.27 10.2 0.0 1.9 3 0 0 3 3 3 0 Type II/IV secretion system protein PBP1_TM PF14812.6 PIK39954.1 - 1.3 9.4 18.9 2.5 8.5 5.7 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt5_N PF11942.8 PIK39954.1 - 6.7 7.8 13.0 1.1 10.3 2.8 2.8 3 0 0 3 3 2 0 Spt5 transcription elongation factor, acidic N-terminal B_lectin PF01453.24 PIK39955.1 - 0.084 13.4 0.3 0.18 12.4 0.1 1.7 1 1 1 2 2 2 0 D-mannose binding lectin SH2 PF00017.24 PIK39956.1 - 4.1e-18 65.2 0.1 5.8e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 SH2 domain START PF01852.19 PIK39957.1 - 3.2e-17 62.6 1.2 3.3e-15 56.1 0.3 2.5 2 1 1 3 3 3 2 START domain RhoGAP PF00620.27 PIK39957.1 - 2.3e-16 60.0 0.2 4e-16 59.2 0.2 1.3 1 0 0 1 1 1 1 RhoGAP domain RR_TM4-6 PF06459.12 PIK39960.1 - 0.025 14.4 2.6 0.04 13.8 2.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BEN PF10523.9 PIK39960.1 - 0.047 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 BEN domain B277 PF17623.2 PIK39960.1 - 5.2 6.0 6.1 2.9 6.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function Transposase_21 PF02992.14 PIK39961.1 - 1.3e-09 37.6 0.1 2.8e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Transposase family tnp2 Lectin_C PF00059.21 PIK39962.1 - 5e-12 46.5 1.2 5.5e-12 46.4 1.2 1.0 1 0 0 1 1 1 1 Lectin C-type domain DOMON PF03351.17 PIK39963.1 - 2.8e-13 50.2 0.0 4.7e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 DOMON domain Zip PF02535.22 PIK39963.1 - 1.3 8.2 4.4 0.34 10.1 0.6 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Jnk-SapK_ap_N PF09744.9 PIK39964.1 - 2.8e-48 164.1 26.2 2.8e-48 164.1 26.2 2.7 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 PIK39964.1 - 1.2e-25 89.5 8.2 1.2e-25 89.5 8.2 4.1 4 1 0 4 4 4 1 JNK-interacting protein leucine zipper II ADIP PF11559.8 PIK39964.1 - 0.29 11.2 38.5 1.6 8.8 18.8 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Glutaredoxin PF00462.24 PIK39966.1 - 1.8e-10 40.9 0.5 8.7e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin SH3BGR PF04908.15 PIK39966.1 - 0.052 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DUF726 PF05277.12 PIK39966.1 - 0.22 10.4 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DnaJ_CXXCXGXG PF00684.19 PIK39966.1 - 0.23 11.8 8.7 0.82 10.1 8.7 2.0 1 1 0 1 1 1 0 DnaJ central domain GATase_6 PF13522.6 PIK39967.1 - 4.4e-12 46.3 0.0 9.1e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 PIK39967.1 - 4e-07 30.0 0.0 8.4e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 PIK39967.1 - 1.7e-05 23.8 0.0 3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II HYR PF02494.16 PIK39968.1 - 1.3e-35 121.6 36.9 2e-13 50.5 0.9 6.7 6 0 0 6 6 6 5 HYR domain EGF PF00008.27 PIK39968.1 - 1.5e-10 41.1 130.1 1.4e-06 28.5 7.2 10.9 11 0 0 11 11 11 5 EGF-like domain PASTA PF03793.19 PIK39968.1 - 2.2e-10 40.2 1.4 0.33 10.8 0.0 5.5 5 0 0 5 5 5 4 PASTA domain hEGF PF12661.7 PIK39968.1 - 0.0017 18.9 93.7 0.0055 17.3 4.8 10.9 7 3 1 8 8 8 5 Human growth factor-like EGF ACTH_assoc PF16102.5 PIK39968.1 - 1.1 10.2 2.5 1.6e+03 0.3 0.0 5.2 6 0 0 6 6 6 0 ACTH-associated domain HYR PF02494.16 PIK39969.1 - 7e-45 151.3 54.7 1.8e-06 28.2 0.8 8.3 8 0 0 8 8 8 8 HYR domain PASTA PF03793.19 PIK39969.1 - 3.6e-08 33.1 14.9 5 7.1 0.0 8.0 8 0 0 8 8 8 4 PASTA domain Big_7 PF17957.1 PIK39969.1 - 2.4e-07 31.4 31.6 0.62 10.9 0.1 8.4 5 2 3 8 8 8 3 Bacterial Ig domain Cry1Ac_D5 PF17997.1 PIK39969.1 - 0.011 15.6 21.5 1.6 8.6 0.1 6.0 5 1 1 6 6 6 0 Insecticidal delta-endotoxin CryIA(c) domain 5 FDF PF09532.10 PIK39969.1 - 0.033 15.1 0.0 64 4.5 0.0 4.8 6 0 0 6 6 6 0 FDF domain ACTH_assoc PF16102.5 PIK39969.1 - 0.68 10.8 12.0 7.6e+02 1.3 0.0 7.9 9 0 0 9 9 9 0 ACTH-associated domain DUF3721 PF12518.8 PIK39969.1 - 1.6 8.6 4.5 3.1e+02 1.3 0.1 4.9 4 0 0 4 4 4 0 Protein of unknown function Alg6_Alg8 PF03155.15 PIK39970.1 - 8.1e-158 526.4 27.9 1e-115 387.5 18.8 2.0 1 1 1 2 2 2 2 ALG6, ALG8 glycosyltransferase family p450 PF00067.22 PIK39971.1 - 6.7e-108 361.4 0.3 8.5e-108 361.1 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Elongin_A PF06881.11 PIK39972.1 - 1e-21 77.4 0.8 3.8e-21 75.6 0.8 2.0 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.11 PIK39972.1 - 1e-09 38.3 0.2 2.7e-09 36.9 0.2 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Peptidase_C78 PF07910.13 PIK39973.1 - 4.3e-60 202.8 0.0 7.8e-60 202.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.12 PIK39973.1 - 2.2e-10 40.6 10.5 0.0026 18.0 0.1 4.4 3 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK39973.1 - 0.00017 22.2 11.3 0.035 14.9 0.6 4.7 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK39973.1 - 0.0097 16.6 5.4 0.089 13.5 0.4 3.8 3 1 2 5 5 5 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 PIK39973.1 - 0.015 15.7 4.2 6.3 7.2 0.6 4.2 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 PIK39973.1 - 1.6 8.6 5.6 53 3.8 0.0 4.0 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) TMEM215 PF15746.5 PIK39975.1 - 2.8 7.3 5.0 1.7 8.0 2.7 1.5 1 1 1 2 2 2 0 TMEM215 family Lig_chan PF00060.26 PIK39976.1 - 2.3e-08 34.0 0.0 3e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK39976.1 - 1.1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 PIK39977.1 - 9.4e-29 99.9 0.0 1.3e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 PIK39977.1 - 3.4e-11 43.0 0.0 5.5e-11 42.3 0.0 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.26 PIK39977.1 - 3.3e-06 27.0 0.1 5e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel TGBp3 PF02495.17 PIK39977.1 - 0.066 12.9 1.0 0.14 11.9 1.0 1.5 1 0 0 1 1 1 0 Triple gene block 3 Methyltransf_11 PF08241.12 PIK39978.1 - 7.5e-22 77.8 0.0 9.9e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK39978.1 - 1.6e-19 70.4 0.0 2e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK39978.1 - 1.1e-13 51.2 0.0 1.3e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK39978.1 - 1.6e-12 48.0 0.0 2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK39978.1 - 1e-10 41.4 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK39978.1 - 5.6e-07 29.6 0.0 6.6e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 PIK39978.1 - 0.00015 21.4 0.0 0.00018 21.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_8 PF05148.15 PIK39978.1 - 0.00022 21.1 0.0 0.00069 19.5 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 PIK39978.1 - 0.0021 17.6 0.0 0.0035 16.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 PIK39978.1 - 0.0024 18.0 0.0 0.003 17.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.16 PIK39978.1 - 0.0038 15.8 0.0 0.0052 15.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 PIK39978.1 - 0.0065 16.5 0.0 0.0086 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK39978.1 - 0.018 14.8 0.0 0.28 10.9 0.1 2.0 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 PIK39978.1 - 0.02 14.2 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_33 PF10017.9 PIK39978.1 - 0.033 13.3 0.0 0.053 12.7 0.0 1.3 1 1 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent TPMT PF05724.11 PIK39978.1 - 0.039 13.6 0.0 0.053 13.2 0.0 1.4 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DREV PF05219.12 PIK39978.1 - 0.069 12.2 0.0 0.087 11.9 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Integrase_H2C2 PF17921.1 PIK39979.1 - 3.1e-22 78.4 0.0 5.3e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK39979.1 - 2.3e-07 31.0 0.0 4.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK39979.1 - 0.0067 16.6 0.0 0.02 15.1 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DUF2577 PF10844.8 PIK39979.1 - 0.18 12.0 0.0 0.38 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2577) RVT_1 PF00078.27 PIK39980.1 - 1.3e-23 83.7 0.0 2.7e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mis12 PF05859.12 PIK39981.1 - 0.18 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Mis12 protein SET PF00856.28 PIK39982.1 - 2.1e-17 64.0 5.3 2.3e-16 60.7 0.7 2.8 2 1 0 2 2 2 1 SET domain preSET_CXC PF18264.1 PIK39982.1 - 9.5e-12 45.2 16.9 9.5e-12 45.2 16.9 3.0 2 1 0 2 2 2 1 CXC domain PRC2_HTH_1 PF18118.1 PIK39982.1 - 5.8e-11 43.1 0.6 4.1e-07 30.7 0.0 4.6 2 2 1 3 3 3 2 Polycomb repressive complex 2 tri-helical domain AWS PF17907.1 PIK39982.1 - 0.0048 16.9 10.8 0.0048 16.9 10.8 4.7 4 1 0 4 4 4 1 AWS domain CDC45 PF02724.14 PIK39982.1 - 0.033 12.5 7.1 0.049 11.9 7.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop PF01798.18 PIK39983.1 - 4.8e-53 180.0 2.0 1.5e-32 112.9 0.1 2.4 2 0 0 2 2 2 2 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 PIK39983.1 - 1e-21 77.0 2.6 4.4e-21 75.0 2.6 2.2 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Cas_Cas1 PF01867.16 PIK39983.1 - 0.016 14.4 0.2 0.026 13.7 0.2 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas1 GRASP55_65 PF04495.14 PIK39984.1 - 9e-71 236.6 0.0 8.1e-50 168.7 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 PIK39984.1 - 6.8e-07 29.5 0.0 0.0027 18.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK39984.1 - 1e-06 28.5 0.0 0.018 14.9 0.0 2.9 2 2 0 2 2 2 2 PDZ domain zf-H2C2_2 PF13465.6 PIK39985.1 - 1.9e-63 208.2 142.9 3.4e-08 33.6 0.5 19.2 19 0 0 19 19 19 14 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39985.1 - 1e-49 164.2 168.6 0.00017 21.9 0.3 17.3 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK39985.1 - 8.4e-39 128.9 162.5 0.0033 18.1 0.4 17.3 17 0 0 17 17 17 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39985.1 - 7.6e-09 35.6 119.0 0.023 15.0 0.3 16.5 17 0 0 17 17 17 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK39985.1 - 8.4e-05 22.8 117.9 0.041 14.3 4.2 15.1 15 0 0 15 15 15 8 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK39985.1 - 0.011 15.5 0.3 0.011 15.5 0.3 12.9 14 0 0 14 14 14 0 zinc-finger C2H2-type zf-Di19 PF05605.12 PIK39985.1 - 0.046 14.0 0.4 0.046 14.0 0.4 10.2 6 3 5 11 11 11 0 Drought induced 19 protein (Di19), zinc-binding Nore1-SARAH PF16517.5 PIK39985.1 - 2 8.4 6.0 11 6.0 0.6 2.9 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain zf-H2C2_2 PF13465.6 PIK39986.1 - 4e-26 90.2 63.6 1.5e-07 31.5 1.5 8.2 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK39986.1 - 4.9e-25 86.5 63.2 0.00016 21.9 0.2 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK39986.1 - 8.5e-24 82.2 59.8 0.00013 22.5 0.2 7.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK39986.1 - 2.6e-09 37.1 42.0 0.013 15.8 0.0 8.9 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK39986.1 - 2.7e-07 30.3 32.3 0.0006 19.7 0.5 7.3 7 0 0 7 7 7 3 zinc-finger of a C2HC-type BolA PF01722.18 PIK39986.1 - 3.6e-07 30.3 11.9 0.02 15.2 2.1 5.2 3 2 1 5 5 5 2 BolA-like protein zf-C2H2_6 PF13912.6 PIK39986.1 - 8.2e-05 22.5 57.6 0.002 18.1 3.1 7.9 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK39986.1 - 0.00043 20.0 44.2 0.078 12.8 0.1 7.3 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-C2HE PF16278.5 PIK39986.1 - 0.00054 20.4 3.5 0.00054 20.4 3.5 7.1 2 2 5 7 7 7 2 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 PIK39986.1 - 0.00057 20.0 25.1 0.1 12.7 0.2 5.9 5 1 1 6 6 6 2 Zinc ribbon domain zf-C2H2_3rep PF18868.1 PIK39986.1 - 0.0019 18.9 27.4 0.8 10.4 0.1 6.8 1 1 5 7 7 7 1 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 PIK39986.1 - 0.0045 17.3 3.8 0.0045 17.3 3.8 8.0 9 1 0 9 9 8 1 Zinc-finger of C2H2 type FYVE PF01363.21 PIK39986.1 - 0.033 14.3 40.0 0.098 12.8 6.2 4.9 1 1 3 4 4 4 0 FYVE zinc finger zinc_ribbon_9 PF14369.6 PIK39986.1 - 0.048 13.9 14.2 7.3 6.9 0.0 5.5 5 1 0 5 5 5 0 zinc-ribbon zf_UBZ PF18439.1 PIK39986.1 - 0.06 12.9 22.1 2.5 7.8 0.2 6.5 7 0 0 7 7 7 0 Ubiquitin-Binding Zinc Finger PyrI_C PF02748.15 PIK39986.1 - 0.11 12.4 26.8 6.1 6.8 0.7 6.9 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Desulfoferrod_N PF06397.12 PIK39986.1 - 0.46 10.1 0.1 0.46 10.1 0.1 5.2 6 0 0 6 6 5 0 Desulfoferrodoxin, N-terminal domain zinc_ribbon_15 PF17032.5 PIK39986.1 - 0.47 11.2 25.8 0.47 11.2 0.2 4.0 2 2 1 4 4 4 0 zinc-ribbon family zf-AN1 PF01428.16 PIK39986.1 - 1.1 9.5 42.9 3.8 7.8 2.0 7.4 5 2 2 7 7 7 0 AN1-like Zinc finger zf-C2H2_2 PF12756.7 PIK39986.1 - 3.8 7.9 38.0 1.3 9.4 0.6 6.7 1 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-FCS PF06467.14 PIK39986.1 - 6.6 6.8 32.7 4.5 7.3 0.3 6.9 4 2 3 7 7 7 0 MYM-type Zinc finger with FCS sequence motif p450 PF00067.22 PIK39987.1 - 5.4e-100 335.3 0.2 4.4e-99 332.3 0.2 1.9 1 1 0 1 1 1 1 Cytochrome P450 JHBP PF06585.11 PIK39987.1 - 0.072 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) FAA_hydrolase_N PF09298.11 PIK39987.1 - 0.077 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal VWC PF00093.18 PIK39988.1 - 2.8e-06 27.5 15.7 2.8e-06 27.5 15.7 1.6 2 0 0 2 2 2 1 von Willebrand factor type C domain TILa PF12714.7 PIK39988.1 - 0.027 14.4 8.3 0.065 13.2 8.3 1.6 1 0 0 1 1 1 0 TILa domain CXCR4_N PF12109.8 PIK39988.1 - 1.3 9.3 5.0 0.48 10.7 0.9 2.3 1 1 1 2 2 2 0 CXCR4 Chemokine receptor N terminal Gal-3-0_sulfotr PF06990.11 PIK39990.1 - 3.1e-38 131.7 0.7 4.4e-38 131.2 0.7 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase DUF659 PF04937.15 PIK39991.1 - 0.002 18.0 0.0 0.0044 16.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Presenilin PF01080.17 PIK39991.1 - 8.1 5.1 6.1 12 4.6 6.1 1.2 1 0 0 1 1 1 0 Presenilin Dimer_Tnp_hAT PF05699.14 PIK39992.1 - 0.029 14.2 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Trypsin PF00089.26 PIK39993.1 - 2.5e-76 256.4 2.9 2.8e-76 256.2 2.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK39993.1 - 3.7e-05 24.6 0.1 5.7e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 PIK39993.1 - 8.2e-05 23.0 0.0 0.00016 22.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) p450 PF00067.22 PIK39994.1 - 1e-28 100.3 0.0 1.2e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM86 PF14904.6 PIK39994.1 - 0.036 14.2 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function TRAPPC9-Trs120 PF08626.11 PIK39995.1 - 3.3e-29 101.0 0.0 2.6e-13 48.3 0.0 3.6 2 1 2 4 4 4 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 PIK39995.1 - 0.0029 16.6 0.2 0.0049 15.9 0.2 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_12 PF13424.6 PIK39995.1 - 0.71 10.2 3.8 1.5 9.1 0.0 3.0 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK39995.1 - 1.1 9.2 2.9 30 4.6 0.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribophorin_II PF05817.14 PIK39997.1 - 1.6e-95 321.0 10.5 1.8e-95 320.8 10.5 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Ribophorin_II PF05817.14 PIK39998.1 - 1.6e-97 327.6 0.6 2e-97 327.3 0.6 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II MG2 PF01835.19 PIK39998.1 - 0.016 15.7 0.0 0.033 14.7 0.0 1.6 1 1 0 1 1 1 0 MG2 domain Invasin_D3 PF09134.10 PIK39998.1 - 0.027 14.8 0.4 0.051 13.9 0.4 1.5 1 1 0 1 1 1 0 Invasin, domain 3 HD_3 PF13023.6 PIK39999.1 - 2.8e-47 160.7 1.0 3.1e-47 160.6 1.0 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 PIK39999.1 - 2e-14 53.7 0.6 2.8e-14 53.3 0.6 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 PIK39999.1 - 4.7e-06 26.8 0.2 1.3e-05 25.4 0.2 1.7 1 1 0 1 1 1 1 HD domain MRP-S35 PF10246.9 PIK40000.1 - 1.9e-45 153.2 0.0 2.1e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 WD40 PF00400.32 PIK40001.1 - 7.6e-37 124.7 29.9 0.00017 22.3 0.1 12.6 13 0 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40001.1 - 1.9e-08 34.5 6.1 0.71 10.2 0.1 8.0 6 2 2 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Kinesin PF00225.23 PIK40002.1 - 1.5e-98 329.8 2.2 1.5e-98 329.8 2.2 3.0 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 PIK40002.1 - 8.9e-17 61.4 0.1 8.9e-17 61.4 0.1 3.5 3 1 1 4 4 4 1 Microtubule binding ATG16 PF08614.11 PIK40002.1 - 0.0001 22.6 37.9 0.0001 22.6 37.9 6.1 2 2 1 3 3 3 1 Autophagy protein 16 (ATG16) Dynamitin PF04912.14 PIK40003.1 - 4e-107 358.9 24.4 4.5e-107 358.7 24.4 1.0 1 0 0 1 1 1 1 Dynamitin FliJ PF02050.16 PIK40003.1 - 0.0048 17.1 15.5 1.8 8.8 0.2 3.6 3 0 0 3 3 3 3 Flagellar FliJ protein Mating_N PF12731.7 PIK40003.1 - 0.011 15.8 6.0 0.45 10.6 0.6 3.0 2 0 0 2 2 2 0 Mating-type protein beta 1 ANAPC16 PF17256.2 PIK40003.1 - 0.019 15.3 0.5 2.2 8.7 0.1 3.3 2 1 0 2 2 2 0 Anaphase-promoting complex, subunit 16 Vpu PF00558.19 PIK40003.1 - 0.15 11.8 3.8 0.2 11.5 0.2 2.6 2 0 0 2 2 2 0 Vpu protein Jnk-SapK_ap_N PF09744.9 PIK40003.1 - 0.25 11.5 20.9 0.23 11.7 2.6 3.8 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DASH_Dad3 PF08656.10 PIK40003.1 - 0.31 11.2 0.1 0.31 11.2 0.1 3.6 3 1 0 3 3 3 0 DASH complex subunit Dad3 ZapB PF06005.12 PIK40003.1 - 0.37 11.3 20.2 2.7 8.5 0.7 4.8 4 1 0 4 4 4 0 Cell division protein ZapB DUF2203 PF09969.9 PIK40003.1 - 0.66 10.7 10.6 3.3 8.5 1.3 3.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Occludin_ELL PF07303.13 PIK40003.1 - 0.88 10.3 12.6 2.1 9.1 0.5 4.0 4 0 0 4 4 4 0 Occludin homology domain TRPM_tetra PF16519.5 PIK40003.1 - 0.99 9.6 9.5 4.5 7.5 0.2 4.1 4 0 0 4 4 4 0 Tetramerisation domain of TRPM Spectrin PF00435.21 PIK40003.1 - 1.1 9.8 22.2 1.9 9.0 0.5 4.0 2 1 2 4 4 4 0 Spectrin repeat ThiD2 PF17792.1 PIK40003.1 - 1.4 9.4 4.6 0.71 10.3 0.5 2.5 2 1 1 3 3 3 0 ThiD2 family Laminin_II PF06009.12 PIK40003.1 - 1.6 8.7 17.7 1.6 8.8 5.7 4.0 3 1 1 4 4 4 0 Laminin Domain II DUF2730 PF10805.8 PIK40003.1 - 2.3 8.4 11.5 23 5.2 0.2 4.4 3 2 1 4 4 4 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.11 PIK40003.1 - 2.6 8.5 11.6 2.2 8.7 0.2 4.8 2 1 1 4 4 4 0 Flagella accessory protein C (FlaC) YlqD PF11068.8 PIK40003.1 - 3.4 8.1 19.4 1.1 9.6 6.5 3.5 3 0 0 3 3 3 0 YlqD protein SOAR PF16533.5 PIK40003.1 - 6 6.9 10.7 0.16 11.9 0.6 3.3 4 1 0 4 4 4 0 STIM1 Orai1-activating region Fzo_mitofusin PF04799.13 PIK40003.1 - 6.8 6.2 11.0 11 5.6 0.8 3.3 3 0 0 3 3 3 0 fzo-like conserved region WW PF00397.26 PIK40004.1 - 1.1e-10 41.4 9.4 1.8e-10 40.7 1.9 3.5 3 0 0 3 3 3 1 WW domain SH3_9 PF14604.6 PIK40004.1 - 1.5e-06 28.0 0.2 3.6e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK40004.1 - 0.0001 21.9 0.0 0.0003 20.3 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_10 PF17902.1 PIK40004.1 - 0.011 15.7 0.0 0.48 10.5 0.0 2.7 3 0 0 3 3 3 0 SH3 domain RhoGAP PF00620.27 PIK40005.1 - 1.9e-35 121.9 0.0 3.2e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 PIK40005.1 - 3.6e-07 30.6 0.0 8.2e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 PH domain DUF1708 PF08101.11 PIK40005.1 - 0.0042 16.3 0.0 0.006 15.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) PH_9 PF15410.6 PIK40005.1 - 0.0057 17.0 0.0 0.017 15.5 0.0 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain KIP1 PF07765.12 PIK40006.1 - 0.095 12.8 2.4 0.52 10.5 0.2 2.7 2 0 0 2 2 2 0 KIP1-like protein YicC_N PF03755.13 PIK40007.1 - 0.04 14.4 1.1 0.073 13.5 1.1 1.5 1 0 0 1 1 1 0 YicC-like family, N-terminal region DUF4205 PF13898.6 PIK40008.1 - 2.8e-121 404.7 0.0 3.5e-121 404.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) 7tm_2 PF00002.24 PIK40009.1 - 3.5e-70 236.1 18.9 4.4e-70 235.8 18.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Insulin_TMD PF17870.1 PIK40009.1 - 1.2 9.3 14.9 1.3 9.1 0.1 3.8 4 0 0 4 4 4 0 Insulin receptor trans-membrane segment Na_H_Exchanger PF00999.21 PIK40010.1 - 2.7e-63 214.1 27.7 3.4e-63 213.7 27.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 PIK40010.1 - 0.027 14.7 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Ras PF00071.22 PIK40011.1 - 2.2e-53 180.2 0.0 2.8e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK40011.1 - 3.5e-30 104.7 0.0 6.6e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK40011.1 - 5.7e-13 48.7 0.0 7.6e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK40011.1 - 0.0004 20.3 0.0 0.47 10.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 PIK40011.1 - 0.00063 19.2 0.0 0.00089 18.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK40011.1 - 0.0042 17.2 0.0 0.008 16.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK40011.1 - 0.0097 15.5 0.0 0.015 14.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DLIC PF05783.11 PIK40012.1 - 1.8e-181 604.1 0.0 2.1e-181 603.9 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 PIK40012.1 - 0.00062 19.0 0.1 0.002 17.4 0.1 1.7 1 1 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 PIK40012.1 - 0.00089 19.5 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 PIK40012.1 - 0.0054 16.5 0.2 0.22 11.3 0.1 2.8 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 PIK40012.1 - 0.0073 15.8 0.1 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family ABC_tran PF00005.27 PIK40012.1 - 0.011 16.2 0.3 0.074 13.6 0.0 2.3 3 0 0 3 3 3 0 ABC transporter AAA_16 PF13191.6 PIK40012.1 - 0.094 13.1 0.0 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain SNAP PF14938.6 PIK40013.1 - 3.5e-25 89.0 21.1 4.9e-25 88.5 21.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 PIK40013.1 - 2.6e-09 37.2 13.1 4e-05 23.8 6.6 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK40013.1 - 1.8e-05 24.3 10.6 2.1e-05 24.1 9.6 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_8 PF13181.6 PIK40013.1 - 0.00071 19.6 20.8 0.23 11.8 1.2 5.5 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK40013.1 - 0.0012 19.3 14.3 0.033 14.7 0.3 4.1 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK40013.1 - 0.0012 18.8 24.6 0.53 10.5 2.6 6.0 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK40013.1 - 0.0032 18.1 12.8 2.7 8.7 0.3 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat DUF4810 PF16068.5 PIK40013.1 - 0.026 15.1 10.0 1.1 9.9 0.0 3.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4810) TPR_10 PF13374.6 PIK40013.1 - 0.027 14.3 10.5 0.63 10.0 0.2 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK40013.1 - 0.052 13.8 14.6 2.7 8.3 0.1 3.8 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 z-alpha PF02295.17 PIK40013.1 - 0.11 12.6 1.0 0.45 10.6 0.1 2.5 3 0 0 3 3 3 0 Adenosine deaminase z-alpha domain Clathrin PF00637.20 PIK40013.1 - 0.17 11.8 8.0 8.5 6.2 3.5 3.6 2 1 1 3 3 3 0 Region in Clathrin and VPS TPR_6 PF13174.6 PIK40013.1 - 0.17 12.6 13.2 10 7.0 0.1 5.6 2 1 4 6 6 6 0 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.7 PIK40013.1 - 0.17 10.8 7.2 0.44 9.5 0.3 2.4 1 1 1 2 2 2 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_1 PF00515.28 PIK40013.1 - 1.1 9.2 22.1 5.1 7.1 0.0 6.0 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK40013.1 - 1.5 8.9 11.9 5.2 7.2 0.2 4.2 3 1 1 4 4 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 PIK40013.1 - 2.5 7.7 11.6 10 5.8 11.4 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_7 PF13176.6 PIK40013.1 - 2.7 8.2 11.3 3.2 8.0 0.1 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat RRM_1 PF00076.22 PIK40014.1 - 1.7e-13 50.2 0.1 2.9e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK40014.1 - 3.8e-05 23.3 0.0 6.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Sec23_Sec24 PF04810.15 PIK40014.1 - 0.41 10.7 1.8 0.54 10.4 0.1 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Cir_N PF10197.9 PIK40015.1 - 3e-08 33.7 6.5 3e-08 33.7 6.5 4.6 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR 5_nucleotid_C PF02872.18 PIK40016.1 - 4.1e-35 121.3 0.0 6.2e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK40016.1 - 6.7e-06 26.8 0.0 1.3e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase POB3_N PF17292.2 PIK40016.1 - 0.12 12.8 0.0 0.34 11.4 0.0 1.7 2 0 0 2 2 2 0 POB3-like N-terminal PH domain DUF667 PF05018.13 PIK40017.1 - 2.6e-76 255.5 1.5 3.4e-76 255.1 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Pkinase PF00069.25 PIK40018.1 - 1.7e-58 198.1 0.1 2e-58 197.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40018.1 - 2.1e-14 53.4 0.0 3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK40018.1 - 6.1e-07 29.6 0.1 1.4e-06 28.4 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK40018.1 - 0.0012 18.5 0.1 0.0018 17.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 PIK40018.1 - 0.0029 17.0 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK40018.1 - 0.0048 15.7 0.0 0.0073 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 PIK40018.1 - 0.0086 15.7 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 PIK40018.1 - 0.017 14.5 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RhoGEF PF00621.20 PIK40019.1 - 2.3e-31 109.4 1.6 5.5e-31 108.2 1.6 1.6 1 0 0 1 1 1 1 RhoGEF domain BBS2_Mid PF14783.6 PIK40019.1 - 0.067 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Erf4 PF10256.9 PIK40020.1 - 1.9e-08 34.4 0.0 2.7e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Myelin_PLP PF01275.19 PIK40021.1 - 7.9e-27 94.6 17.2 1.1e-26 94.2 17.2 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) PTPS_related PF10131.9 PIK40021.1 - 0.0031 15.9 2.2 0.0044 15.4 2.2 1.2 1 0 0 1 1 1 1 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF468 PF04318.12 PIK40021.1 - 0.086 13.6 0.1 0.22 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF468) UPF0093 PF03653.13 PIK40021.1 - 0.1 12.9 5.2 0.16 12.2 0.9 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0093) DUF4064 PF13273.6 PIK40021.1 - 0.76 10.1 13.7 0.16 12.3 3.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Chromate_transp PF02417.15 PIK40021.1 - 3.6 7.7 12.3 1 9.5 7.9 2.0 2 0 0 2 2 2 0 Chromate transporter 7tm_1 PF00001.21 PIK40022.1 - 6.1e-46 156.9 0.9 1.1e-45 156.1 0.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK40022.1 - 3.6e-11 42.9 9.5 5.5e-11 42.3 9.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK40022.1 - 3.3e-10 40.0 15.3 5.1e-10 39.4 15.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK40022.1 - 0.025 14.1 14.5 0.037 13.5 14.5 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc p450 PF00067.22 PIK40023.1 - 4.3e-49 167.5 0.0 7.1e-49 166.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 PIK40024.1 - 2.7e-46 158.1 0.0 4.3e-46 157.4 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family PEARLI-4 PF05278.12 PIK40026.1 - 0.18 11.4 3.1 0.28 10.7 3.1 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) LIM_bind PF01803.16 PIK40027.1 - 2.4e-48 164.8 7.5 1.4e-46 159.0 2.2 2.6 2 1 0 2 2 2 1 LIM-domain binding protein LID PF17916.1 PIK40027.1 - 7.8e-20 70.2 2.6 1.8e-19 69.0 2.6 1.7 1 0 0 1 1 1 1 LIM interaction domain (LID) Pex14_N PF04695.13 PIK40027.1 - 9 6.9 8.2 1.7 9.3 4.5 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LRR_8 PF13855.6 PIK40028.1 - 1.4e-50 168.9 49.2 4.8e-14 51.9 2.3 7.6 3 3 5 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 PIK40028.1 - 3.4e-21 75.0 43.2 3.6e-06 27.2 0.6 8.4 5 1 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK40028.1 - 1.2e-18 67.3 0.8 8.5e-06 25.8 0.6 3.4 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK40028.1 - 6.4e-08 32.3 15.1 0.0025 17.3 0.5 3.5 2 1 0 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK40028.1 - 1.2e-06 28.2 27.3 0.51 11.1 0.4 10.8 11 0 0 11 11 11 2 Leucine Rich Repeat T_cell_tran_alt PF15128.6 PIK40028.1 - 0.022 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 T-cell leukemia translocation-altered LRR_6 PF13516.6 PIK40028.1 - 0.19 11.8 30.2 3.1 8.1 0.1 8.4 9 0 0 9 9 9 0 Leucine Rich repeat LRR_8 PF13855.6 PIK40029.1 - 6.3e-49 163.6 52.0 6.1e-13 48.3 1.3 7.8 3 3 6 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 PIK40029.1 - 3.8e-19 68.5 57.2 1.5e-06 28.5 1.4 8.9 5 2 5 10 10 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK40029.1 - 5.2e-18 65.2 1.8 0.00011 22.2 1.2 3.4 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK40029.1 - 2e-06 27.4 18.8 0.0051 16.3 0.9 4.1 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 PIK40029.1 - 2.6e-06 27.2 38.3 0.72 10.6 0.7 11.9 13 1 0 13 13 13 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK40029.1 - 0.0094 15.9 36.2 1.7 8.9 0.1 9.8 9 0 0 9 9 9 3 Leucine Rich repeat CD34_antigen PF06365.12 PIK40029.1 - 0.0095 15.5 0.1 0.021 14.4 0.1 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family Insulin_TMD PF17870.1 PIK40029.1 - 0.096 12.8 1.6 0.21 11.7 1.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment TMEM154 PF15102.6 PIK40029.1 - 2 8.3 11.6 15 5.5 11.6 2.3 1 1 0 1 1 1 0 TMEM154 protein family NUC173 PF08161.12 PIK40031.1 - 1.5e-69 233.7 2.1 5e-66 222.3 0.0 4.5 5 0 0 5 5 5 2 NUC173 domain Xpo1 PF08389.12 PIK40031.1 - 0.00093 19.3 8.7 0.43 10.6 0.0 5.2 5 0 0 5 5 5 2 Exportin 1-like protein Bmt2 PF11968.8 PIK40031.1 - 0.034 14.0 0.9 0.067 13.0 0.9 1.5 1 0 0 1 1 1 0 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 RhoGAP PF00620.27 PIK40031.1 - 2.2 8.1 4.9 2.5 7.9 0.2 3.2 4 0 0 4 4 4 0 RhoGAP domain MAGE PF01454.19 PIK40031.1 - 2.9 7.5 6.0 2.7 7.6 1.8 2.5 2 0 0 2 2 2 0 MAGE family PTS_2-RNA PF01885.16 PIK40032.1 - 1.6e-45 155.4 0.0 3.9e-22 79.2 0.0 2.0 1 1 1 2 2 2 2 RNA 2'-phosphotransferase, Tpt1 / KptA family Asparaginase_2 PF01112.18 PIK40033.1 - 1.3e-26 93.3 0.7 1.6e-26 93.1 0.7 1.0 1 0 0 1 1 1 1 Asparaginase Asparaginase_2 PF01112.18 PIK40034.1 - 4.3e-69 232.9 2.2 5.2e-69 232.6 2.2 1.0 1 0 0 1 1 1 1 Asparaginase zf-CCHC PF00098.23 PIK40037.1 - 5.5e-08 32.5 19.4 0.0012 18.8 3.8 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK40037.1 - 3e-05 23.7 18.2 0.12 12.1 2.5 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK40037.1 - 0.0014 18.5 19.4 0.079 12.8 0.2 3.5 3 0 0 3 3 3 2 Zinc knuckle PP-binding_2 PF14573.6 PIK40037.1 - 0.25 11.6 1.2 4.9 7.5 0.2 2.5 3 0 0 3 3 3 0 Acyl-carrier DUF4220 PF13968.6 PIK40038.1 - 0.052 13.0 0.0 0.066 12.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF3287 PF11690.8 PIK40038.1 - 0.22 11.3 1.3 0.43 10.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Exo_endo_phos PF03372.23 PIK40039.1 - 1.1e-09 38.1 0.1 1.4e-09 37.9 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UCH PF00443.29 PIK40040.1 - 5.8e-40 137.4 0.1 1.1e-39 136.5 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 PIK40040.1 - 6.1e-21 74.9 1.2 8.9e-21 74.3 0.2 1.9 2 0 0 2 2 2 1 DUSP domain EF-hand_6 PF13405.6 PIK40040.1 - 1e-13 50.0 2.5 0.00091 19.0 0.1 4.7 6 0 0 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 PIK40040.1 - 1.6e-13 49.2 3.3 0.00024 20.4 0.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 PIK40040.1 - 2.5e-12 47.0 1.6 5.2e-08 33.2 0.6 3.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK40040.1 - 2.3e-09 36.3 1.9 0.015 14.7 0.1 3.6 3 0 0 3 3 3 3 EF hand Ubiquitin_3 PF14836.6 PIK40040.1 - 6.5e-08 32.4 0.7 4.7e-06 26.5 0.1 2.7 2 0 0 2 2 2 1 Ubiquitin-like domain EF-hand_8 PF13833.6 PIK40040.1 - 4.8e-05 23.1 0.3 3.4 7.6 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain pair UCH_1 PF13423.6 PIK40040.1 - 9e-05 22.2 0.0 0.00051 19.7 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SPARC_Ca_bdg PF10591.9 PIK40040.1 - 0.042 14.2 0.3 6.5 7.1 0.0 3.2 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region UCH PF00443.29 PIK40041.1 - 8.2e-30 104.1 0.0 9.6e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK40041.1 - 1.3e-10 41.4 0.0 2.5e-10 40.4 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SpoIIE PF07228.12 PIK40042.1 - 1.4e-12 48.0 0.0 2.6e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 PIK40042.1 - 8e-08 32.2 0.0 1.9e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 PIK40042.1 - 1.3e-06 28.3 0.0 0.00049 19.8 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C GCP_N_terminal PF17681.1 PIK40043.1 - 1.9e-34 119.7 1.7 2.7e-34 119.2 1.7 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Gluconate_2-dh3 PF13618.6 PIK40043.1 - 0.025 14.8 0.9 0.047 13.9 0.6 1.7 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 GCP_C_terminal PF04130.13 PIK40044.1 - 3.5e-54 184.4 10.8 5.1e-54 183.8 10.8 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Pro_sub2 PF18513.1 PIK40044.1 - 0.015 15.5 2.2 0.24 11.6 0.1 2.7 2 0 0 2 2 2 0 Prodomain subtilisin 2 SOGA PF11365.8 PIK40045.1 - 4.4e-06 27.7 10.9 2.3e-05 25.4 0.6 12.5 3 1 6 11 11 11 3 Protein SOGA DUF1515 PF07439.11 PIK40045.1 - 4.4e-05 23.5 1.5 4.4e-05 23.5 1.5 6.7 8 4 2 10 10 10 1 Protein of unknown function (DUF1515) HLH PF00010.26 PIK40047.1 - 9.1e-18 64.0 0.9 1.6e-17 63.2 0.9 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 PIK40047.1 - 1.1e-10 41.5 0.5 2.1e-10 40.6 0.5 1.4 1 0 0 1 1 1 1 Hairy Orange MRP-S35 PF10246.9 PIK40048.1 - 8.2e-45 151.1 0.0 1.2e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 HD_3 PF13023.6 PIK40049.1 - 8.1e-47 159.2 1.3 9.9e-47 158.9 1.3 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 PIK40049.1 - 4e-14 52.8 1.3 5.5e-14 52.3 1.3 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 PIK40049.1 - 4.4e-06 26.9 0.3 1.2e-05 25.5 0.1 1.7 1 1 0 1 1 1 1 HD domain Ribophorin_II PF05817.14 PIK40050.1 - 3.2e-202 673.5 11.5 3.6e-202 673.3 11.5 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF1425 PF07233.12 PIK40050.1 - 0.018 14.9 0.3 0.045 13.6 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1425) MG2 PF01835.19 PIK40050.1 - 0.046 14.2 0.6 0.25 11.8 0.0 2.6 3 0 0 3 3 3 0 MG2 domain TRAPPC9-Trs120 PF08626.11 PIK40051.1 - 1.8e-34 118.5 0.0 8.3e-14 50.0 0.0 3.9 3 1 1 4 4 4 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 PIK40051.1 - 0.0022 17.0 0.2 0.0038 16.3 0.2 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit PLU-1 PF08429.11 PIK40051.1 - 0.18 11.0 0.8 0.43 9.7 0.3 1.7 2 0 0 2 2 2 0 PLU-1-like protein TPR_12 PF13424.6 PIK40051.1 - 0.18 12.1 1.6 1.4 9.3 0.0 2.7 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40051.1 - 0.62 10.0 1.9 28 4.8 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat PKD PF00801.20 PIK40052.1 - 0.045 13.6 0.1 0.086 12.7 0.1 1.4 1 0 0 1 1 1 0 PKD domain p450 PF00067.22 PIK40053.1 - 4.6e-11 42.1 0.0 5.4e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM86 PF14904.6 PIK40053.1 - 0.032 14.3 0.0 0.064 13.4 0.0 1.5 1 1 0 1 1 1 0 Family of unknown function NACHT PF05729.12 PIK40054.1 - 2e-07 31.1 0.0 4.9e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain DUF4723 PF15851.5 PIK40054.1 - 0.0055 16.8 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4723) ER PF01133.17 PIK40054.1 - 0.033 14.2 0.5 0.1 12.6 0.5 1.8 1 0 0 1 1 1 0 Enhancer of rudimentary NAD_binding_5 PF07994.12 PIK40054.1 - 0.04 13.3 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase SWM_repeat PF13753.6 PIK40054.1 - 0.079 13.1 0.0 0.31 11.2 0.1 1.9 2 0 0 2 2 2 0 Putative flagellar system-associated repeat NLRC4_HD PF17889.1 PIK40054.1 - 0.14 12.5 4.0 1.3 9.3 0.0 2.9 3 0 0 3 3 3 0 NLRC4 helical domain AAA_25 PF13481.6 PIK40054.1 - 0.15 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF4208 PF13907.6 PIK40057.1 - 3e-15 56.4 0.1 6.9e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) SLIDE PF09111.10 PIK40057.1 - 0.00019 21.4 0.7 0.0019 18.2 0.2 2.8 2 1 0 2 2 2 1 SLIDE Myb_DNA-binding PF00249.31 PIK40057.1 - 0.02 15.1 0.1 0.065 13.4 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Vps51 PF08700.11 PIK40059.1 - 4.8e-16 58.6 2.8 4.8e-16 58.6 2.8 2.1 2 0 0 2 2 2 1 Vps51/Vps67 ApoLp-III PF07464.11 PIK40059.1 - 0.0018 18.4 5.0 0.098 12.7 1.7 3.3 3 0 0 3 3 3 1 Apolipophorin-III precursor (apoLp-III) Dor1 PF04124.12 PIK40059.1 - 0.0021 16.8 0.8 0.0052 15.5 0.8 1.7 1 0 0 1 1 1 1 Dor1-like family BORCS8 PF10167.9 PIK40059.1 - 0.01 15.8 0.9 0.04 13.9 0.9 2.1 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 DRY_EERY PF09750.9 PIK40059.1 - 0.04 14.2 0.8 0.081 13.2 0.8 1.5 1 0 0 1 1 1 0 Alternative splicing regulator Apolipoprotein PF01442.18 PIK40059.1 - 0.12 12.3 3.8 0.12 12.3 0.7 2.1 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain VAPB_antitox PF02697.14 PIK40059.1 - 0.17 12.7 4.0 0.15 12.8 0.5 2.5 2 0 0 2 2 2 0 Putative antitoxin Vps54_N PF10475.9 PIK40059.1 - 0.18 11.1 9.4 0.052 12.8 2.6 2.7 3 1 0 3 3 3 0 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 PIK40059.1 - 0.21 11.8 2.8 0.38 10.9 1.0 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Zw10 PF06248.13 PIK40059.1 - 0.22 10.0 7.8 0.022 13.4 3.4 1.4 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 KxDL PF10241.9 PIK40059.1 - 0.98 9.7 6.6 1.1 9.5 2.4 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein KH_1 PF00013.29 PIK40061.1 - 7.5e-28 96.2 2.6 2.4e-15 56.1 0.0 2.7 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 PIK40061.1 - 0.00017 21.3 0.1 0.14 12.0 0.0 2.6 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 PIK40061.1 - 0.0011 18.7 0.0 0.68 9.9 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 PIK40061.1 - 0.075 13.1 0.2 8.4 6.6 0.0 2.3 2 0 0 2 2 2 0 NusA-like KH domain PBS_linker_poly PF00427.21 PIK40063.1 - 0.099 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide Xpo1 PF08389.12 PIK40064.1 - 4.4e-20 72.2 16.4 2.4e-14 53.7 0.1 5.2 5 1 1 6 6 6 2 Exportin 1-like protein IBN_N PF03810.19 PIK40064.1 - 4.4e-07 29.7 4.0 7.6e-07 29.0 0.1 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain DUF1722 PF08349.11 PIK40064.1 - 0.015 15.5 0.9 4 7.7 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) NUC130_3NT PF08158.12 PIK40064.1 - 0.054 13.8 0.2 0.53 10.7 0.1 2.8 2 0 0 2 2 2 0 NUC130/3NT domain RPW8 PF05659.11 PIK40064.1 - 0.079 12.6 2.4 0.7 9.6 0.0 3.4 4 0 0 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phage_int_SAM_1 PF02899.17 PIK40065.1 - 0.00031 21.0 0.8 0.0006 20.1 0.1 1.8 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK40065.1 - 0.00082 19.8 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Ig_3 PF13927.6 PIK40066.1 - 1.4e-09 38.4 0.0 2.7e-09 37.5 0.0 1.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40066.1 - 1.4e-06 28.6 0.0 2.5e-06 27.7 0.0 1.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK40066.1 - 6.6e-05 22.9 0.0 0.00015 21.7 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK40066.1 - 0.00028 21.0 0.0 0.0019 18.4 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK40066.1 - 0.063 13.3 0.0 0.077 13.1 0.0 1.2 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK40066.1 - 0.14 11.7 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain RT_RNaseH_2 PF17919.1 PIK40067.1 - 3.9e-31 107.1 0.1 8.1e-31 106.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40067.1 - 1.5e-29 102.3 0.0 3.2e-29 101.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40067.1 - 1.9e-19 70.1 0.1 3.6e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK40067.1 - 1.3e-16 60.4 1.2 1.3e-16 60.4 1.2 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK40067.1 - 1.6e-06 28.2 0.2 4.1e-06 26.9 0.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Y_phosphatase PF00102.27 PIK40068.1 - 1.2e-81 273.7 1.5 1.7e-48 165.3 0.2 3.1 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK40068.1 - 6.9e-07 29.1 0.1 0.0006 19.6 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Phage_glycop_gL PF11108.8 PIK40068.1 - 0.0065 16.5 0.0 5.1 7.2 0.0 2.5 2 0 0 2 2 2 2 Viral glycoprotein L PTPlike_phytase PF14566.6 PIK40068.1 - 0.0087 16.2 1.1 0.42 10.7 0.0 3.6 3 2 1 4 4 4 1 Inositol hexakisphosphate Hrs_helical PF12210.8 PIK40068.1 - 0.048 14.2 0.8 0.2 12.2 0.1 2.2 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Y_phosphatase PF00102.27 PIK40069.1 - 2.4e-07 30.6 0.0 1.3e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Fz PF01392.22 PIK40069.1 - 0.0036 17.9 3.1 0.0096 16.5 3.1 1.8 1 1 0 1 1 1 1 Fz domain TMEM154 PF15102.6 PIK40069.1 - 0.085 12.8 1.2 0.16 11.8 0.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family DUF3377 PF11857.8 PIK40069.1 - 0.11 12.5 0.2 0.27 11.2 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) OAD_gamma PF04277.13 PIK40069.1 - 0.11 13.1 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SKG6 PF08693.10 PIK40069.1 - 0.48 9.9 7.7 1.1 8.7 7.7 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Folate_rec PF03024.14 PIK40069.1 - 3.6 7.4 6.5 20 5.0 6.5 2.1 1 1 0 1 1 1 0 Folate receptor family ECM11 PF15463.6 PIK40070.1 - 1.5 9.4 7.5 4.7 7.8 0.0 3.3 4 0 0 4 4 4 0 Extracellular mutant protein 11 HYR PF02494.16 PIK40071.1 - 8.1e-20 70.9 1.4 1.8e-19 69.8 1.4 1.6 1 0 0 1 1 1 1 HYR domain Calx-beta PF03160.14 PIK40071.1 - 0.0031 17.7 0.1 0.01 16.0 0.0 1.9 3 0 0 3 3 3 1 Calx-beta domain Phospholamban PF04272.14 PIK40072.1 - 0.018 14.5 1.9 0.046 13.2 1.9 1.7 1 0 0 1 1 1 0 Phospholamban DUF805 PF05656.14 PIK40072.1 - 4.1 7.9 9.3 8.5 6.8 9.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF805) PAN_1 PF00024.26 PIK40073.1 - 6.4e-13 48.5 16.4 5.1e-09 36.0 2.6 3.2 3 1 0 3 3 3 2 PAN domain SecG PF03840.14 PIK40073.1 - 0.17 12.0 0.3 2.6 8.2 0.1 2.1 2 0 0 2 2 2 0 Preprotein translocase SecG subunit Herpes_UL52 PF03121.15 PIK40073.1 - 1.1 9.3 7.5 0.46 10.4 0.8 2.9 3 0 0 3 3 3 0 Herpesviridae UL52/UL70 DNA primase SRCR PF00530.18 PIK40074.1 - 7.1e-115 376.2 46.2 1e-28 99.8 4.7 4.9 4 1 1 5 5 5 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK40074.1 - 1.2e-24 86.7 21.3 6.4e-06 26.6 0.5 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK40074.1 - 9.9e-11 42.1 0.0 0.96 10.0 0.0 4.4 4 0 0 4 4 4 4 Hepsin, SRCR domain DUF333 PF03891.15 PIK40074.1 - 0.0035 17.5 0.1 90 3.4 0.0 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF333) TcfC PF16967.5 PIK40074.1 - 0.03 13.8 3.1 32 4.1 0.1 4.3 4 1 1 5 5 5 0 E-set like domain Imm39 PF15568.6 PIK40074.1 - 0.14 12.3 6.2 1e+02 3.0 0.1 4.8 4 1 1 5 5 5 0 Immunity protein 39 DNA_ligase_C PF17879.1 PIK40074.1 - 0.65 10.1 8.4 90 3.2 0.0 4.2 4 0 0 4 4 4 0 DNA ligase C-terminal domain Stealth_CR1 PF17101.5 PIK40074.1 - 0.97 9.2 3.7 1.3e+02 2.4 0.1 3.9 4 0 0 4 4 4 0 Stealth protein CR1, conserved region 1 SRCR PF00530.18 PIK40075.1 - 5.3e-27 94.3 0.1 6.6e-27 93.9 0.1 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK40075.1 - 8.4e-05 23.0 0.0 0.00014 22.3 0.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain RT_RNaseH PF17917.1 PIK40076.1 - 1.5e-36 124.8 0.0 3.4e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40076.1 - 5.8e-33 112.9 0.0 1.1e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40076.1 - 2.8e-11 43.4 0.0 4.7e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3417 PF11897.8 PIK40076.1 - 0.26 11.8 0.8 5.5 7.5 0.0 3.1 3 1 0 4 4 4 0 Protein of unknown function (DUF3417) rve PF00665.26 PIK40077.1 - 1.6e-15 57.4 0.0 1.9e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK40077.1 - 0.0083 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain PAN_1 PF00024.26 PIK40078.1 - 1.2e-05 25.2 5.7 1.6e-05 24.8 5.7 1.2 1 0 0 1 1 1 1 PAN domain Aminotran_1_2 PF00155.21 PIK40079.1 - 1.5e-30 106.6 0.0 1.7e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 PIK40079.1 - 0.00075 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3754 PF12576.8 PIK40080.1 - 2.5e-19 69.6 0.0 4.7e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) RVT_1 PF00078.27 PIK40082.1 - 2.6e-20 72.9 0.0 4e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK40082.1 - 0.0012 19.5 0.0 0.0033 18.0 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC_5 PF14787.6 PIK40082.1 - 0.0015 18.2 2.1 0.003 17.2 2.1 1.5 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 PIK40082.1 - 0.0018 18.3 3.0 0.0045 17.0 3.0 1.7 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK40082.1 - 0.0041 17.6 0.0 0.0094 16.5 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RT_RNaseH_2 PF17919.1 PIK40083.1 - 4.4e-35 119.7 0.1 1e-34 118.6 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40083.1 - 2.9e-30 104.7 0.0 5.5e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK40083.1 - 3.8e-17 62.1 1.4 1.2e-16 60.5 1.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK40083.1 - 6.8e-17 61.8 0.0 1.9e-16 60.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_3 PF13456.6 PIK40083.1 - 0.0061 16.4 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase-like zf-H2C2 PF09337.10 PIK40083.1 - 0.0099 16.1 0.2 0.022 14.9 0.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger KxDL PF10241.9 PIK40083.1 - 0.012 15.8 0.0 0.072 13.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein RT_RNaseH_2 PF17919.1 PIK40084.1 - 1.4e-37 127.7 0.0 2.3e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40084.1 - 5.1e-33 113.5 0.0 1.2e-32 112.3 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK40084.1 - 3.4e-17 62.3 1.7 3.4e-17 62.3 1.7 2.3 3 0 0 3 3 3 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK40084.1 - 1e-10 41.5 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK40084.1 - 0.007 16.6 0.8 0.007 16.6 0.8 1.9 2 0 0 2 2 2 1 H2C2 zinc finger IGFBP PF00219.18 PIK40084.1 - 0.97 10.1 7.0 7.5 7.3 0.4 2.6 2 0 0 2 2 2 0 Insulin-like growth factor binding protein zf-CXXC PF02008.20 PIK40084.1 - 1.1 9.3 8.4 2.4 8.2 1.4 2.7 2 0 0 2 2 2 0 CXXC zinc finger domain rve PF00665.26 PIK40085.1 - 3.7e-22 78.7 0.0 2.7e-21 76.0 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain hGDE_central PF14702.6 PIK40085.1 - 0.013 15.1 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme rve_3 PF13683.6 PIK40085.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain PCB_OB PF17092.5 PIK40085.1 - 0.045 14.5 0.0 0.081 13.7 0.0 1.4 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain RPAP3_C PF13877.6 PIK40086.1 - 0.0024 18.4 0.3 0.012 16.1 0.0 2.3 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 Cir_Bir_Yir PF06022.11 PIK40086.1 - 0.014 14.9 0.9 0.025 14.1 0.1 1.9 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir GED PF02212.18 PIK40086.1 - 0.2 11.8 4.8 33 4.7 0.6 4.3 3 1 0 3 3 3 0 Dynamin GTPase effector domain Cytochrom_D1 PF02239.16 PIK40088.1 - 0.051 12.1 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain ACT PF01842.25 PIK40088.1 - 0.075 12.8 0.6 0.18 11.6 0.2 1.8 2 0 0 2 2 2 0 ACT domain GAS PF13851.6 PIK40089.1 - 0.00013 21.4 31.0 0.00013 21.4 31.0 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding FPP PF05911.11 PIK40089.1 - 0.022 13.0 30.0 0.03 12.5 30.0 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil YtxH PF12732.7 PIK40089.1 - 0.05 14.1 15.9 0.75 10.4 7.7 3.4 1 1 1 2 2 2 0 YtxH-like protein Mce4_CUP1 PF11887.8 PIK40089.1 - 0.16 11.4 4.9 0.23 10.9 4.9 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative Tektin PF03148.14 PIK40089.1 - 0.22 10.2 31.0 0.48 9.1 19.5 3.0 1 1 2 3 3 3 0 Tektin family DUF1664 PF07889.12 PIK40089.1 - 0.52 10.4 16.7 0.14 12.2 3.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FUSC PF04632.12 PIK40089.1 - 0.62 8.5 7.0 0.71 8.3 7.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.11 PIK40089.1 - 0.8 8.5 39.7 0.18 10.7 25.1 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1598 PF07643.11 PIK40089.1 - 0.8 10.0 4.6 1.3 9.3 0.8 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1598) DUF2514 PF10721.9 PIK40089.1 - 1 9.4 10.5 0.59 10.1 8.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DASH_Dam1 PF08653.10 PIK40089.1 - 1.7 8.5 5.4 11 5.9 0.1 3.3 2 1 1 3 3 3 0 DASH complex subunit Dam1 LPP PF04728.13 PIK40089.1 - 2.9 8.3 8.6 1.9 8.9 0.1 3.8 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Cupin_8 PF13621.6 PIK40089.1 - 4.4 6.9 15.1 92 2.6 14.8 2.2 1 1 0 1 1 1 0 Cupin-like domain CREPT PF16566.5 PIK40089.1 - 5 7.3 25.9 0.022 14.9 9.6 3.4 1 1 3 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour ERM PF00769.19 PIK40089.1 - 5.5 6.7 44.0 2.6 7.8 36.4 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF883 PF05957.13 PIK40089.1 - 6.6 7.4 16.4 0.31 11.7 5.7 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.10 PIK40089.1 - 8.4 6.6 26.3 4.2 7.5 9.4 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 PIK40089.1 - 9.2 6.1 33.5 2.4 7.9 16.0 3.3 1 1 1 3 3 3 0 Phage minor structural protein GP20 Golgin_A5 PF09787.9 PIK40089.1 - 9.3 5.6 38.9 1.2 8.5 21.2 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 PIK40089.1 - 9.4 6.3 14.3 2.2 8.3 4.2 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RPAP3_C PF13877.6 PIK40090.1 - 0.0029 18.1 0.2 0.0083 16.6 0.0 1.8 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 zf-CGNR PF11706.8 PIK40090.1 - 2.8 7.9 6.5 0.69 9.8 0.1 3.0 3 1 0 3 3 3 0 CGNR zinc finger RHD3 PF05879.12 PIK40091.1 - 1.4e-09 36.8 0.0 1.4e-09 36.8 0.0 2.6 2 1 0 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 PIK40091.1 - 5.5e-07 29.1 0.1 1.3e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 PIK40091.1 - 3.6e-06 27.1 0.7 2.2e-05 24.6 0.6 2.5 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK40091.1 - 7.7e-05 22.8 0.0 0.00023 21.2 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK40091.1 - 0.047 14.1 1.4 0.57 10.5 0.0 3.1 3 2 0 3 3 3 0 AAA ATPase domain Amidinotransf PF02274.17 PIK40091.1 - 0.81 8.7 5.1 1.1 8.3 0.1 3.1 3 1 0 3 3 3 0 Amidinotransferase Death PF00531.22 PIK40092.1 - 0.0011 19.1 0.0 0.0034 17.5 0.0 1.9 1 0 0 1 1 1 1 Death domain DED PF01335.21 PIK40092.1 - 0.0025 18.1 0.2 0.0057 16.9 0.2 1.7 1 0 0 1 1 1 1 Death effector domain RGS PF00615.19 PIK40093.1 - 0.041 14.1 0.3 2.3 8.5 0.1 2.7 2 0 0 2 2 2 0 Regulator of G protein signaling domain VWC PF00093.18 PIK40094.1 - 1.2e-37 128.0 100.7 6.4e-11 42.4 13.0 11.7 6 3 3 9 9 9 6 von Willebrand factor type C domain Antistasin PF02822.14 PIK40094.1 - 1.3e-10 41.7 67.5 1.9e-06 28.4 10.6 15.2 19 1 0 19 19 19 5 Antistasin family TILa PF12714.7 PIK40094.1 - 4e-08 33.1 31.6 4.8e-05 23.2 5.5 11.6 10 3 2 12 12 12 6 TILa domain Pacifastin_I PF05375.13 PIK40094.1 - 2.3e-06 27.2 41.9 0.00075 19.2 5.7 10.9 10 1 1 11 11 11 6 Pacifastin inhibitor (LCMII) Amnionless PF14828.6 PIK40094.1 - 0.00032 19.6 14.2 0.00032 19.6 14.2 6.8 4 2 3 7 7 7 2 Amnionless Vault PF01505.18 PIK40094.1 - 0.16 12.2 0.3 10 6.4 0.0 2.7 2 0 0 2 2 2 0 Major Vault Protein repeat domain Actin PF00022.19 PIK40095.1 - 5e-116 387.7 0.0 4e-115 384.7 0.0 1.9 1 1 0 1 1 1 1 Actin AAA_9 PF12781.7 PIK40096.1 - 2.3e-76 255.8 0.4 2.3e-76 255.8 0.4 3.9 4 0 0 4 4 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 PIK40096.1 - 1.5e-74 250.6 0.2 2.4e-74 249.9 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_lid_11 PF18198.1 PIK40096.1 - 9.5e-64 214.1 0.0 2.2e-63 213.0 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK40096.1 - 1.4e-48 163.9 0.0 6e-46 155.4 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK40096.1 - 3.9e-35 121.5 18.1 1.9e-34 119.3 0.0 3.2 4 0 0 4 4 4 2 Microtubule-binding stalk of dynein motor DHR10 PF18595.1 PIK40096.1 - 0.0021 18.1 5.5 0.0021 18.1 5.5 3.2 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain ATG16 PF08614.11 PIK40096.1 - 0.015 15.5 1.1 0.015 15.5 1.1 3.9 4 1 0 4 4 3 0 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 PIK40096.1 - 0.15 12.2 2.3 1.8 8.7 0.4 2.8 2 0 0 2 2 2 0 TolA binding protein trimerisation Exonuc_VII_L PF02601.15 PIK40096.1 - 0.26 10.8 6.9 1.8 8.1 0.0 2.5 3 0 0 3 3 3 0 Exonuclease VII, large subunit COG2 PF06148.11 PIK40096.1 - 0.58 10.2 8.9 5.3 7.1 1.9 3.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 PIK40096.1 - 0.64 8.8 30.8 0.019 13.8 6.6 2.8 3 0 0 3 3 3 0 Spc7 kinetochore protein HemX PF04375.14 PIK40096.1 - 0.92 8.7 8.1 0.6 9.3 1.6 2.3 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase NPV_P10 PF05531.12 PIK40096.1 - 8.9 6.9 8.8 45 4.6 0.3 3.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_6 PF12774.7 PIK40097.1 - 1.4e-148 494.2 2.2 9.2e-138 458.7 0.0 3.9 4 0 0 4 4 4 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK40097.1 - 2.1e-129 432.1 12.2 1.2e-104 350.6 2.4 3.0 3 1 1 4 4 4 2 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 PIK40097.1 - 1.9e-87 291.4 0.1 4.8e-85 283.6 0.0 3.1 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 PIK40097.1 - 1e-19 70.5 0.0 3.4e-19 68.9 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 PIK40097.1 - 3.2e-18 66.0 0.0 3.9e-05 23.7 0.0 5.0 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 PIK40097.1 - 9.2e-14 51.4 4.7 5e-11 42.4 0.3 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region D4 Dynein_AAA_lid PF17852.1 PIK40097.1 - 2.3e-10 40.6 0.1 1.3e-09 38.2 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA PF00004.29 PIK40097.1 - 2.6e-06 27.9 0.6 0.92 9.9 0.0 4.5 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK40097.1 - 0.00033 21.1 0.0 0.74 10.2 0.0 3.2 2 0 0 2 2 2 2 AAA ATPase domain RNA_helicase PF00910.22 PIK40097.1 - 0.00057 20.2 0.1 3 8.3 0.0 4.1 4 0 0 4 4 3 1 RNA helicase AAA_18 PF13238.6 PIK40097.1 - 0.00068 20.2 2.8 0.076 13.6 0.0 4.1 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 PIK40097.1 - 0.0011 19.3 1.8 0.82 9.9 0.0 4.2 5 0 0 5 5 4 1 AAA domain AAA_30 PF13604.6 PIK40097.1 - 0.0056 16.4 0.1 1.2 8.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 PIK40097.1 - 0.0076 16.0 0.6 7.4 6.2 0.0 3.8 4 0 0 4 4 4 1 AAA domain BLOC1_2 PF10046.9 PIK40097.1 - 0.023 15.0 4.7 0.018 15.3 1.5 2.6 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 T2SSE PF00437.20 PIK40097.1 - 0.082 12.0 0.2 0.43 9.6 0.0 2.2 3 0 0 3 3 3 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 PIK40097.1 - 0.11 11.4 0.0 1.4 7.7 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.21 PIK40097.1 - 0.16 11.4 0.3 13 5.1 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 PIK40097.1 - 0.16 11.7 0.1 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.15 PIK40097.1 - 0.2 11.6 1.3 2.5 8.1 0.0 3.1 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit PhoH PF02562.16 PIK40097.1 - 0.23 10.9 1.9 12 5.3 0.0 3.4 3 0 0 3 3 3 0 PhoH-like protein SAS4 PF15460.6 PIK40097.1 - 8.5 6.6 9.7 1.4 9.1 2.4 3.1 3 0 0 3 3 3 0 Something about silencing, SAS, complex subunit 4 FKBP_C PF00254.28 PIK40098.1 - 9.6e-16 57.9 0.1 1.2e-15 57.6 0.1 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Borrelia_REV PF03978.13 PIK40098.1 - 0.01 15.8 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein GLTP PF08718.11 PIK40099.1 - 1.1e-41 142.6 0.0 2.7e-41 141.3 0.0 1.7 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PH PF00169.29 PIK40099.1 - 3.6e-11 43.5 2.3 4e-11 43.3 0.1 2.3 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 PIK40099.1 - 0.00039 20.8 1.4 0.00039 20.8 1.4 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain Ax_dynein_light PF10211.9 PIK40099.1 - 2.9 7.8 8.1 0.87 9.5 0.4 2.7 3 0 0 3 3 3 0 Axonemal dynein light chain PDZ_6 PF17820.1 PIK40100.1 - 1.6e-12 47.0 0.0 2.5e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK40100.1 - 2.9e-12 46.7 0.0 4.5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK40100.1 - 6.5e-06 26.4 0.0 9.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF4178 PF13785.6 PIK40100.1 - 0.026 14.6 0.1 0.046 13.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) GRASP55_65 PF04495.14 PIK40100.1 - 0.052 13.9 0.0 0.064 13.6 0.0 1.1 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain FMO-like PF00743.19 PIK40101.1 - 5e-52 177.0 0.0 5.5e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK40101.1 - 2.6e-16 59.7 0.0 3.9e-16 59.2 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK40101.1 - 3.4e-12 46.2 0.0 3.9e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK40101.1 - 1.4e-07 31.0 0.1 3.3e-07 29.8 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK40101.1 - 4.4e-06 26.8 0.0 1e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 PIK40101.1 - 0.006 16.6 0.1 0.72 9.8 0.1 2.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 PIK40101.1 - 0.014 15.9 0.0 1.7 9.3 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 PIK40101.1 - 0.016 14.5 0.4 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 PIK40101.1 - 0.022 13.8 0.0 0.04 13.0 0.0 1.4 2 0 0 2 2 2 0 FAD binding domain Eno-Rase_NADH_b PF12242.8 PIK40101.1 - 0.036 13.8 1.3 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DAO PF01266.24 PIK40101.1 - 0.085 12.4 0.2 2.1 7.8 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 PIK40101.1 - 0.085 13.3 0.0 6.7 7.2 0.0 2.3 2 1 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 PIK40101.1 - 0.15 12.1 0.1 20 5.3 0.0 2.5 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 PIK40101.1 - 0.16 10.6 0.1 0.34 9.5 0.1 1.4 2 0 0 2 2 2 0 HI0933-like protein Glyco_transf_10 PF00852.19 PIK40102.1 - 1.4e-44 151.9 0.0 1.7e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 PIK40103.1 - 1.3e-09 38.0 0.0 1.8e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK40103.1 - 5.6e-07 30.0 0.1 1.1e-06 29.1 0.1 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK40104.1 - 5.5e-36 123.9 0.2 6.5e-36 123.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Leader_CPA1 PF08252.11 PIK40104.1 - 0.062 12.7 0.2 0.15 11.5 0.2 1.7 1 0 0 1 1 1 0 arg-2/CPA1 leader peptide UCMA PF17085.5 PIK40105.1 - 0.12 12.4 4.0 0.12 12.4 4.0 1.0 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Peptidase_M28 PF04389.17 PIK40106.1 - 3.1e-19 69.4 0.0 7.4e-19 68.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 PIK40106.1 - 3.2e-14 52.7 0.0 1.7e-13 50.4 0.0 2.2 3 0 0 3 3 3 1 PA domain TFR_dimer PF04253.15 PIK40106.1 - 4.3e-14 52.7 0.0 8.8e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M20 PF01546.28 PIK40106.1 - 0.0079 15.9 0.0 0.026 14.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Thioredoxin_13 PF18401.1 PIK40107.1 - 0.0037 17.2 0.1 0.01 15.7 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain SET PF00856.28 PIK40109.1 - 2.5e-22 80.1 0.2 9.3e-22 78.2 0.2 1.9 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 PIK40109.1 - 5.3e-18 65.7 10.0 5.3e-18 65.7 10.0 2.3 2 1 0 2 2 2 1 Pre-SET motif AWS PF17907.1 PIK40109.1 - 0.0048 16.9 2.6 0.0048 16.9 2.6 2.8 3 0 0 3 3 3 1 AWS domain DRMBL PF07522.14 PIK40110.1 - 1.7e-12 47.5 0.5 4.3e-12 46.2 0.5 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 PIK40110.1 - 6.2e-05 23.1 0.1 0.00011 22.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK40110.1 - 0.00066 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DNA_repr_REX1B PF14966.6 PIK40110.1 - 0.0044 17.7 0.0 0.015 16.0 0.0 1.9 1 0 0 1 1 1 1 DNA repair REX1-B RMMBL PF07521.12 PIK40110.1 - 0.046 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Carn_acyltransf PF00755.20 PIK40111.1 - 4.2e-187 623.4 0.0 4.8e-187 623.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF667 PF05018.13 PIK40112.1 - 6.3e-27 94.5 0.2 1.7e-26 93.1 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF667) OCRE PF17780.1 PIK40112.1 - 0.028 14.4 0.2 0.099 12.7 0.2 2.0 1 0 0 1 1 1 0 OCRE domain AAA_12 PF13087.6 PIK40113.1 - 5.4e-50 169.8 0.0 1.1e-49 168.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK40113.1 - 2e-26 93.3 0.0 4.1e-13 49.7 0.0 2.4 1 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 PIK40113.1 - 1.5e-09 38.3 0.0 4.8e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK40113.1 - 2.6e-09 37.1 0.0 1.1e-08 35.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK40113.1 - 0.00027 21.0 0.0 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 PIK40113.1 - 0.0042 16.6 0.0 0.016 14.7 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region zf-met PF12874.7 PIK40113.1 - 0.0052 17.1 0.2 0.017 15.5 0.0 2.0 2 0 0 2 2 1 1 Zinc-finger of C2H2 type AAA_22 PF13401.6 PIK40113.1 - 0.0067 16.7 0.0 0.032 14.5 0.0 2.2 2 0 0 2 2 1 1 AAA domain PhoH PF02562.16 PIK40113.1 - 0.016 14.7 0.0 0.47 9.9 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA PF00004.29 PIK40113.1 - 0.02 15.3 0.0 0.049 14.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 PIK40113.1 - 0.031 14.1 0.0 0.25 11.2 0.0 2.2 2 0 0 2 2 2 0 Helicase AAA_16 PF13191.6 PIK40113.1 - 0.036 14.4 0.0 0.088 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain UvrD-helicase PF00580.21 PIK40113.1 - 0.057 12.9 0.0 0.31 10.5 0.0 2.2 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Sigma54_activat PF00158.26 PIK40113.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Methyltransf_3 PF01596.17 PIK40114.1 - 3.1e-31 108.2 0.0 3.9e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 PIK40114.1 - 5.6e-08 33.8 0.0 8.1e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK40114.1 - 9.9e-08 32.6 0.0 1.6e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK40114.1 - 6e-07 29.4 0.0 8.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK40114.1 - 0.00015 21.2 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK40114.1 - 0.00057 20.6 0.0 0.00088 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK40114.1 - 0.00067 20.3 0.0 0.0011 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK40114.1 - 0.0063 16.3 0.0 0.0082 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 PIK40114.1 - 0.043 13.4 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_9 PF08003.11 PIK40114.1 - 0.05 12.5 0.0 0.066 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MTS PF05175.14 PIK40114.1 - 0.094 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain NACHT PF05729.12 PIK40115.1 - 5.3e-11 42.7 0.0 1.1e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain GPI2 PF06432.11 PIK40115.1 - 0.00023 20.7 0.1 0.00027 20.5 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_25 PF13481.6 PIK40115.1 - 0.00099 18.7 0.0 0.0043 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain PNMA PF14893.6 PIK40116.1 - 0.016 14.6 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 PNMA Apolipo_F PF15148.6 PIK40116.1 - 0.021 14.3 0.1 0.033 13.7 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein F Rnk_N PF14760.6 PIK40116.1 - 1.2 9.7 4.1 1 9.9 0.4 2.5 2 1 0 2 2 2 0 Rnk N-terminus RT_RNaseH_2 PF17919.1 PIK40117.1 - 5.5e-30 103.4 0.0 1.1e-29 102.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40117.1 - 1.6e-23 83.0 0.0 3.8e-23 81.8 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40117.1 - 1.3e-05 24.9 0.2 0.00079 19.0 0.1 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) CKS PF01111.19 PIK40119.1 - 0.046 14.0 0.0 0.068 13.4 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase regulatory subunit RVT_1 PF00078.27 PIK40121.1 - 4.8e-53 179.9 0.0 2e-28 99.4 0.0 2.5 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK40121.1 - 7.3e-23 80.5 0.1 1.6e-22 79.4 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40121.1 - 8.7e-11 42.0 0.0 2.1e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF1677 PF07911.13 PIK40121.1 - 0.078 13.4 0.5 0.34 11.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1677) rve PF00665.26 PIK40122.1 - 2e-15 57.0 0.0 3.3e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK40122.1 - 0.0013 18.5 0.0 0.0036 17.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40124.1 - 5.1e-10 39.3 3.0 1.1e-09 38.2 3.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK40124.1 - 0.00063 19.9 0.0 0.00099 19.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK40124.1 - 0.037 14.3 6.4 0.049 13.8 5.0 2.0 2 0 0 2 2 2 0 H2C2 zinc finger RVT_1 PF00078.27 PIK40125.1 - 3.2e-14 53.0 0.0 3.8e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK40126.1 - 0.00063 19.7 3.2 0.0013 18.8 3.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK40126.1 - 0.044 13.5 0.5 0.11 12.3 0.5 1.7 1 0 0 1 1 1 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK40127.1 - 0.00011 21.8 0.3 0.00014 21.5 0.3 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RE_AlwI PF09491.10 PIK40129.1 - 0.043 12.6 2.2 0.065 12.0 2.2 1.2 1 0 0 1 1 1 0 AlwI restriction endonuclease wnt PF00110.19 PIK40129.1 - 0.062 12.9 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 wnt family RsbU_N PF08673.10 PIK40129.1 - 0.27 11.4 1.6 2.9 8.0 0.1 2.4 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain RVT_1 PF00078.27 PIK40131.1 - 1.5e-08 34.4 0.0 2.2e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arena_nucleocap PF00843.17 PIK40131.1 - 0.029 13.3 0.1 0.04 12.8 0.1 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain RVT_1 PF00078.27 PIK40133.1 - 1.9e-07 30.9 0.0 7.5e-05 22.3 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) FXMRP1_C_core PF12235.8 PIK40135.1 - 0.072 13.7 6.5 0.24 12.0 5.0 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal PRR20 PF15708.5 PIK40135.1 - 7.7 6.3 8.0 13 5.7 8.0 1.3 1 0 0 1 1 1 0 Proline-rich protein family 20 MMM1 PF10296.9 PIK40137.1 - 0.00023 20.3 0.0 0.00036 19.7 0.0 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Ntox15 PF15604.6 PIK40139.1 - 0.16 12.0 0.6 0.26 11.4 0.3 1.4 2 0 0 2 2 2 0 Novel toxin 15 RRM_1 PF00076.22 PIK40140.1 - 0.00041 20.1 0.0 0.00069 19.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 PIK40141.1 - 1.4e-11 44.8 3.2 2e-09 37.9 1.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Patatin PF01734.22 PIK40141.1 - 2.4e-10 40.9 1.0 4.6e-10 40.0 1.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase Ank_5 PF13857.6 PIK40141.1 - 3.4e-09 36.8 3.1 0.00013 22.2 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK40141.1 - 4.7e-07 30.2 4.2 0.00094 19.7 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK40141.1 - 7.2e-07 29.4 4.0 0.63 10.6 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 PIK40141.1 - 3.6e-06 26.9 2.0 0.087 13.4 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Exo_endo_phos_2 PF14529.6 PIK40142.1 - 2.6e-09 36.9 0.4 5.1e-09 36.0 0.4 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK40142.1 - 2.4e-07 30.5 0.0 4.9e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AMP-binding PF00501.28 PIK40143.1 - 5.5e-77 259.1 0.0 6.6e-77 258.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme M20_dimer PF07687.14 PIK40144.1 - 2.1e-05 24.4 0.0 4.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 PIK40145.1 - 5.6e-11 42.5 0.0 2.8e-05 23.9 0.7 2.1 1 1 1 2 2 2 2 Peptidase family M20/M25/M40 M20_dimer PF07687.14 PIK40145.1 - 1.8e-10 40.7 0.0 3.8e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain PSK PF06404.12 PIK40145.1 - 0.021 15.8 0.1 0.086 13.9 0.1 2.0 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) TbpB_C PF17483.2 PIK40145.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 C-lobe handle domain of Tf-binding protein B PP2C PF00481.21 PIK40146.1 - 9.1e-58 195.9 0.0 1.1e-57 195.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK40146.1 - 1.1e-05 25.2 0.0 2.3e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_8 PF01501.20 PIK40147.1 - 0.00047 19.8 0.0 0.00051 19.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 PI3Ka PF00613.20 PIK40148.1 - 1.7e-58 197.0 0.7 3.4e-58 196.1 0.7 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 PIK40148.1 - 3.2e-55 187.7 0.7 1.6e-54 185.4 0.7 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 PIK40148.1 - 8.1e-22 77.6 0.0 1.6e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 PIK40148.1 - 0.0031 16.9 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI3K_p85B PF02192.16 PIK40149.1 - 1.6e-22 79.0 0.0 2.7e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain IQ PF00612.27 PIK40150.1 - 2.5e-11 42.3 38.3 0.0019 17.8 3.4 6.6 6 0 0 6 6 6 6 IQ calmodulin-binding motif DUF1473 PF07341.11 PIK40150.1 - 0.14 11.9 3.6 0.3 10.9 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1473) Senescence_reg PF04520.13 PIK40150.1 - 2.6 8.9 7.8 0.15 12.9 0.8 2.3 2 1 0 2 2 2 0 Senescence regulator Peptidase_C14 PF00656.22 PIK40152.1 - 1.3e-49 169.4 0.0 2.3e-49 168.6 0.0 1.4 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 PIK40152.1 - 2.7e-10 40.1 0.0 5.3e-09 36.0 0.0 2.4 2 0 0 2 2 2 1 Caspase recruitment domain CARD_2 PF16739.5 PIK40152.1 - 0.0034 17.3 0.0 0.0065 16.4 0.0 1.5 1 0 0 1 1 1 1 Caspase recruitment domain MSA-2c PF12238.8 PIK40152.1 - 0.39 10.7 2.0 0.67 9.9 0.8 1.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c Anp1 PF03452.14 PIK40153.1 - 1.2e-06 28.2 0.7 0.061 12.7 0.0 3.0 3 0 0 3 3 3 2 Anp1 2OG-FeII_Oxy_3 PF13640.6 PIK40153.1 - 6.2e-05 23.8 0.0 0.00019 22.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 PIK40154.1 - 3.5e-40 135.2 21.6 3.8e-07 30.7 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40154.1 - 2.4e-14 53.4 0.0 0.0096 16.2 0.1 5.3 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK40154.1 - 0.00087 19.2 0.0 2.8 7.8 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK40154.1 - 0.012 14.6 0.9 5.3 5.9 0.1 3.8 2 1 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein E1-E2_ATPase PF00122.20 PIK40155.1 - 4.1e-28 98.1 0.0 4.1e-28 98.1 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase P5-ATPase PF12409.8 PIK40155.1 - 8.8e-24 84.0 0.1 1.7e-23 83.0 0.1 1.6 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 PIK40155.1 - 8.6e-15 55.6 0.0 2.6e-09 37.7 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK40155.1 - 8e-07 29.1 0.0 1.6e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 PIK40155.1 - 0.00047 19.9 2.0 0.001 18.8 0.6 2.3 1 1 0 1 1 1 1 Cation transporting ATPase, C-terminus NnrU PF07298.11 PIK40155.1 - 0.085 12.4 1.3 0.92 9.0 0.1 2.6 2 0 0 2 2 2 0 NnrU protein Cyclin_N PF00134.23 PIK40156.1 - 1.2e-11 44.5 2.3 2.6e-08 33.7 0.3 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK40156.1 - 2.9e-05 24.1 0.4 0.00049 20.2 0.1 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 PIK40156.1 - 0.00036 20.9 0.0 0.00088 19.6 0.0 1.8 1 0 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.19 PIK40156.1 - 0.0006 19.8 0.2 1.2 9.3 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Raftlin PF15250.6 PIK40158.1 - 0.082 11.7 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Raftlin Phage_integrase PF00589.22 PIK40160.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family Phage_int_SAM_4 PF13495.6 PIK40160.1 - 0.021 15.3 0.0 0.043 14.3 0.0 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK40160.1 - 0.054 13.8 2.1 0.055 13.8 0.1 2.0 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RXLR_WY PF18634.1 PIK40161.1 - 2.7e-09 36.8 11.5 10 6.1 0.0 9.0 9 0 0 9 9 9 2 RXLR phytopathogen effector protein WY-domain PEPCK_N PF17297.2 PIK40161.1 - 3.9e-05 23.4 0.3 0.86 9.2 0.1 3.6 2 2 2 4 4 4 2 Phosphoenolpyruvate carboxykinase N-terminal domain FAINT PF04385.15 PIK40161.1 - 0.0011 19.0 0.1 15 5.7 0.0 5.2 3 2 3 6 6 6 1 Domain of unknown function, DUF529 DUF4809 PF16067.5 PIK40161.1 - 0.012 15.8 0.3 41 4.4 0.0 5.0 1 1 5 6 6 6 0 Domain of unknown function (DUF4809) DUF1910 PF08928.10 PIK40161.1 - 0.031 14.3 1.4 4.2 7.4 0.1 3.9 3 2 0 3 3 3 0 Domain of unknown function (DUF1910) CesT PF05932.13 PIK40161.1 - 0.036 14.2 0.8 8.8 6.5 0.0 4.4 3 3 1 4 4 4 0 Tir chaperone protein (CesT) family COR PF16095.5 PIK40161.1 - 0.081 12.7 0.1 1.3e+02 2.3 0.0 4.7 3 2 4 7 7 7 0 C-terminal of Roc, COR, domain Profilin PF00235.19 PIK40161.1 - 0.097 12.9 3.0 26 5.1 0.0 4.6 2 1 3 5 5 5 0 Profilin Ribonuc_red_2_N PF08471.10 PIK40161.1 - 0.12 12.6 0.2 29 4.9 0.0 3.9 2 2 3 5 5 5 0 Class II vitamin B12-dependent ribonucleotide reductase APH_6_hur PF04655.14 PIK40161.1 - 0.23 10.8 0.0 3 7.1 0.0 2.6 4 0 0 4 4 4 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Paramecium_SA PF01508.16 PIK40161.1 - 1.7 9.1 25.4 52 4.4 0.1 7.7 6 2 1 8 8 8 0 Paramecium surface antigen domain TSP_1 PF00090.19 PIK40162.1 - 8.2e-10 38.8 21.5 2.6e-05 24.4 1.9 3.0 3 0 0 3 3 3 2 Thrombospondin type 1 domain Metallothio_PEC PF02068.16 PIK40162.1 - 3.9 7.9 11.8 9.4 6.7 10.9 2.1 1 1 1 2 2 2 0 Plant PEC family metallothionein TSP_1 PF00090.19 PIK40163.1 - 1.9e-10 40.8 26.7 0.00022 21.4 4.0 4.7 4 1 0 4 4 4 3 Thrombospondin type 1 domain I-set PF07679.16 PIK40163.1 - 0.044 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain TSP_1 PF00090.19 PIK40164.1 - 0.00033 20.8 8.5 0.00033 20.8 8.5 2.3 2 2 0 2 2 2 1 Thrombospondin type 1 domain Npun_R1517 PF18068.1 PIK40165.1 - 0.2 12.0 0.1 0.47 10.8 0.1 1.7 2 0 0 2 2 2 0 Npun R1517 DUF5641 PF18701.1 PIK40169.1 - 9.5e-33 112.2 2.9 1.3e-32 111.8 2.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DUF4841 PF16129.5 PIK40170.1 - 0.021 15.1 0.1 0.8 10.0 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4841) DUF1759 PF03564.15 PIK40170.1 - 0.029 14.3 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) zf-CHY PF05495.12 PIK40170.1 - 9 6.9 18.9 1.3 9.5 5.0 2.5 1 1 1 2 2 2 0 CHY zinc finger VapB_antitoxin PF09957.9 PIK40171.1 - 0.061 13.2 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB Y_phosphatase PF00102.27 PIK40172.1 - 5.1e-24 85.1 0.2 1e-23 84.1 0.2 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK40172.1 - 7.4e-07 29.4 3.2 7.9e-05 22.9 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK40172.1 - 0.018 15.6 0.5 0.77 10.4 0.0 2.6 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK40172.1 - 0.049 14.0 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Oxidored_q2 PF00420.24 PIK40172.1 - 0.049 13.3 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Orf78 PF06024.12 PIK40172.1 - 0.15 12.4 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Mif2_N PF15624.6 PIK40173.1 - 0.023 15.4 1.4 0.023 15.4 1.4 4.9 2 2 3 5 5 5 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal BTP PF05232.12 PIK40174.1 - 0.026 14.6 2.1 6.8 6.8 0.7 3.2 2 0 0 2 2 2 0 Chlorhexidine efflux transporter T4SS_CagC PF16943.5 PIK40174.1 - 5.8 7.1 7.2 0.44 10.7 0.8 2.4 3 0 0 3 3 3 0 Cag pathogenicity island, type IV secretory system LRR_8 PF13855.6 PIK40175.1 - 2.6e-12 46.3 4.0 8.8e-07 28.6 0.1 3.2 1 1 4 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 PIK40175.1 - 9.8e-06 25.8 1.6 0.0034 17.8 0.2 3.9 2 1 3 5 5 5 2 Leucine Rich repeats (2 copies) SopE_GEF PF07487.13 PIK40175.1 - 3.1e-05 24.1 0.2 5.9e-05 23.2 0.2 1.4 1 0 0 1 1 1 1 SopE GEF domain LRR_5 PF13306.6 PIK40175.1 - 9.8e-05 22.3 1.1 0.00013 21.9 0.2 1.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ephrin_rec_like PF07699.13 PIK40175.1 - 0.03 14.1 26.9 0.046 13.5 5.4 5.0 3 1 2 5 5 5 0 Putative ephrin-receptor like LRR_9 PF14580.6 PIK40175.1 - 0.19 11.2 0.1 0.29 10.6 0.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 PIK40175.1 - 0.23 12.1 1.0 38 5.4 0.2 4.3 3 1 1 4 4 4 0 Leucine Rich Repeat Fibrinogen_C PF00147.18 PIK40176.1 - 8.7e-45 153.2 19.9 1.1e-43 149.6 19.9 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK40176.1 - 2.5e-11 43.3 12.8 2.5e-11 43.3 12.8 4.9 4 2 2 6 6 6 1 TILa domain TIL PF01826.17 PIK40176.1 - 3.6e-05 23.9 12.0 3.6e-05 23.9 12.0 4.5 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK40176.1 - 0.00062 19.9 11.1 0.00062 19.9 11.1 4.5 2 2 1 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK40177.1 - 4.6e-36 124.7 16.7 7.3e-36 124.0 16.7 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK40177.1 - 0.0066 16.6 10.5 0.0066 16.6 10.5 2.6 2 0 0 2 2 2 1 EGF domain EGF PF00008.27 PIK40177.1 - 0.019 15.3 5.3 0.094 13.0 5.3 2.3 1 0 0 1 1 1 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK40177.1 - 0.34 11.0 12.3 0.073 13.1 8.2 2.2 2 0 0 2 2 2 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK40178.1 - 6.1e-40 137.4 15.0 4.9e-39 134.4 15.0 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK40178.1 - 5.6e-09 35.8 10.9 5.6e-09 35.8 10.9 4.3 2 2 2 4 4 4 1 TILa domain TIL PF01826.17 PIK40178.1 - 5.5e-06 26.5 12.6 5.5e-06 26.5 12.6 5.1 4 1 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK40178.1 - 0.012 15.8 10.4 0.012 15.8 10.4 5.1 4 1 0 4 4 4 0 EGF domain Fibrinogen_C PF00147.18 PIK40179.1 - 3.2e-38 131.7 12.3 4.3e-38 131.3 12.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK40179.1 - 4.5e-08 32.9 11.5 4.5e-08 32.9 11.5 4.4 2 2 1 3 3 3 1 TILa domain TIL PF01826.17 PIK40179.1 - 1.3e-05 25.4 13.2 1.3e-05 25.4 13.2 3.9 3 2 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK40179.1 - 0.00033 20.8 9.4 0.00033 20.8 9.4 4.5 3 2 0 4 4 4 1 EGF domain TILa PF12714.7 PIK40180.1 - 2.7e-12 46.4 11.3 2.7e-12 46.4 11.3 3.9 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK40180.1 - 1.3e-06 28.5 16.8 1.3e-06 28.5 16.8 3.7 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK40180.1 - 0.021 15.0 12.6 0.021 15.0 12.6 4.3 3 2 1 4 4 4 0 EGF domain EGF_MSP1_1 PF12946.7 PIK40180.1 - 0.04 14.0 28.6 0.097 12.7 6.1 4.0 3 1 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK40181.1 - 1.3e-63 214.8 4.0 1.6e-63 214.5 4.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain LRR_8 PF13855.6 PIK40182.1 - 1e-27 95.6 16.2 1.5e-15 56.7 4.5 2.8 2 1 0 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 PIK40182.1 - 4.8e-14 52.4 2.5 1.2e-13 51.1 2.5 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40182.1 - 1.1e-13 51.1 21.9 4.3e-05 23.8 0.6 3.9 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK40182.1 - 2.1e-06 27.3 4.5 3.2e-05 23.5 1.4 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK40182.1 - 6.6e-05 22.9 17.8 2 9.3 0.0 7.0 6 1 1 7 7 7 2 Leucine Rich Repeat TIR PF01582.20 PIK40182.1 - 0.00046 20.0 0.1 0.00065 19.5 0.1 1.2 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.6 PIK40182.1 - 0.0069 16.4 13.8 0.073 13.2 0.1 4.6 5 0 0 5 5 5 2 Leucine Rich repeat Rax2 PF12768.7 PIK40182.1 - 0.082 12.3 0.6 2.1 7.8 0.6 2.2 1 1 0 1 1 1 0 Cortical protein marker for cell polarity TIR_2 PF13676.6 PIK40182.1 - 0.15 12.7 0.0 0.33 11.6 0.0 1.6 1 0 0 1 1 1 0 TIR domain C1_1 PF00130.22 PIK40183.1 - 9.1e-07 28.7 6.9 2.1e-06 27.5 6.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 PIK40183.1 - 0.00016 21.1 0.0 0.00026 20.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-HC5HC2H_2 PF13832.6 PIK40183.1 - 0.0039 17.3 0.7 0.008 16.3 0.7 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 PIK40183.1 - 0.0056 16.9 1.5 0.013 15.7 1.5 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain C1_2 PF03107.16 PIK40183.1 - 0.0086 16.4 2.7 0.021 15.2 2.7 1.7 1 0 0 1 1 1 1 C1 domain Prok-RING_1 PF14446.6 PIK40183.1 - 0.035 14.0 4.8 0.11 12.5 4.8 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 PIK40183.1 - 0.11 12.9 3.7 0.28 11.5 3.7 1.7 1 0 0 1 1 1 0 RING-like domain zf_CCCH_5 PF18384.1 PIK40183.1 - 0.18 12.0 2.8 0.42 10.8 2.8 1.5 1 0 0 1 1 1 0 Unkempt Zinc finger domain 1 (Znf1) PHD PF00628.29 PIK40183.1 - 0.19 11.6 6.3 0.11 12.5 3.6 2.0 2 0 0 2 2 2 0 PHD-finger zf-C5HC2 PF02928.16 PIK40183.1 - 0.27 11.7 6.5 0.71 10.3 6.5 1.7 1 0 0 1 1 1 0 C5HC2 zinc finger Pkinase_Tyr PF07714.17 PIK40184.1 - 1.7e-13 50.4 0.0 2.2e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40184.1 - 8.4e-09 35.2 0.0 1.1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Cpn60_TCP1 PF00118.24 PIK40185.1 - 4.9e-168 559.8 6.2 5.6e-168 559.6 6.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PilM_2 PF11104.8 PIK40185.1 - 0.023 13.7 0.9 0.2 10.6 0.0 2.5 3 0 0 3 3 3 0 Type IV pilus assembly protein PilM; GalP_UDP_tr_C PF02744.17 PIK40186.1 - 1.8e-59 200.2 0.5 4.1e-59 199.1 0.5 1.5 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.22 PIK40186.1 - 2e-42 145.7 3.0 9e-22 78.4 0.1 2.5 3 0 0 3 3 3 2 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.23 PIK40186.1 - 4.1e-05 24.2 0.0 0.0018 19.0 0.0 2.4 2 0 0 2 2 2 1 HIT domain zf-CCHC_4 PF14392.6 PIK40186.1 - 0.058 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle DcpS_C PF11969.8 PIK40186.1 - 0.064 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding DUF4931 PF16285.5 PIK40186.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) V-set PF07686.17 PIK40188.1 - 2.7e-12 46.8 1.9 4.8e-07 29.9 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain NACHT PF05729.12 PIK40188.1 - 5.2e-11 42.7 0.0 1.4e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 NACHT domain Ig_3 PF13927.6 PIK40188.1 - 1.4e-07 32.0 0.1 0.00084 19.9 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK40188.1 - 1.2e-05 25.2 0.1 0.00013 22.0 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK40188.1 - 0.018 15.4 1.4 0.62 10.4 0.0 3.3 3 0 0 3 3 3 0 Immunoglobulin domain IstB_IS21 PF01695.17 PIK40188.1 - 0.1 12.3 0.0 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Peptidase_A17 PF05380.13 PIK40189.1 - 8.8e-26 90.8 0.0 1.2e-25 90.5 0.0 1.1 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK40190.1 - 1.1e-11 44.7 0.0 1.5e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_11 PF13086.6 PIK40191.1 - 5.5e-46 157.5 2.2 6.2e-46 157.3 0.2 2.1 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 PIK40191.1 - 2.5e-25 89.3 0.7 2.5e-25 89.3 0.7 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK40191.1 - 7e-13 48.7 0.0 1.9e-11 44.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK40191.1 - 2.5e-09 37.6 0.0 8.3e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK40191.1 - 0.0033 17.7 0.1 0.046 14.0 0.0 2.7 1 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK40191.1 - 0.011 15.0 0.0 0.026 13.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 PIK40191.1 - 0.012 15.4 0.9 0.046 13.5 0.1 2.4 2 1 0 3 3 3 0 DEAD/DEAH box helicase Mg_chelatase PF01078.21 PIK40191.1 - 0.091 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNB PF00773.19 PIK40192.1 - 0.027 13.8 0.0 0.11 11.8 0.0 2.0 1 1 0 1 1 1 0 RNB domain Hemopexin PF00045.19 PIK40193.1 - 6.2e-39 131.7 14.6 4.6e-14 52.1 0.1 4.2 4 0 0 4 4 4 4 Hemopexin Glycoprotein_B PF00606.18 PIK40193.1 - 0.4 10.1 1.2 9.9 5.5 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus Glycoprotein B ectodomain Herpes_teg_N PF04843.12 PIK40194.1 - 7.5e-14 51.7 0.0 1.3e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus tegument protein, N-terminal conserved region FlgT_M PF16539.5 PIK40194.1 - 0.045 13.9 0.6 0.36 11.0 0.1 2.5 2 1 1 3 3 3 0 Flagellar assembly protein T, middle domain Alpha-amylase PF00128.24 PIK40197.1 - 6.4e-47 160.7 0.0 2.8e-31 109.3 0.1 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Lig_chan PF00060.26 PIK40198.1 - 1.6e-17 63.7 0.0 2e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK40198.1 - 0.035 13.5 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.26 PIK40199.1 - 1.8e-17 63.6 0.7 2e-17 63.4 0.7 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK40199.1 - 0.023 14.1 0.0 0.026 14.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 PIK40199.1 - 0.057 13.6 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 Ligated ion channel L-glutamate- and glycine-binding site RIFIN PF02009.16 PIK40200.1 - 0.037 13.9 1.5 0.052 13.4 1.5 1.2 1 0 0 1 1 1 0 Rifin Ig_3 PF13927.6 PIK40201.1 - 0.015 15.9 1.5 0.032 14.8 0.3 2.1 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK40201.1 - 0.72 10.1 3.6 1 9.5 1.6 2.2 2 1 0 2 2 2 0 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK40202.1 - 0.0001 22.2 0.7 0.0001 22.2 0.7 2.9 1 1 0 2 2 1 1 TMEM154 protein family Insulin_TMD PF17870.1 PIK40202.1 - 0.002 18.1 1.0 0.004 17.2 1.0 1.4 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment I-set PF07679.16 PIK40202.1 - 0.0026 17.8 0.0 0.018 15.1 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40202.1 - 0.0027 18.3 0.2 0.0027 18.3 0.2 2.9 2 1 0 2 2 2 1 Immunoglobulin domain EphA2_TM PF14575.6 PIK40202.1 - 0.0098 16.8 0.2 0.031 15.2 0.1 1.9 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ninjurin PF04923.12 PIK40202.1 - 0.03 14.3 0.7 0.09 12.7 0.1 2.1 2 0 0 2 2 2 0 Ninjurin SIT PF15330.6 PIK40202.1 - 0.054 13.9 1.8 0.96 9.9 1.8 2.6 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM51 PF15345.6 PIK40202.1 - 0.23 11.3 4.2 0.24 11.2 1.7 2.3 2 1 1 3 3 3 0 Transmembrane protein 51 Comm PF15957.5 PIK40202.1 - 0.54 10.6 3.6 0.35 11.2 0.6 2.4 1 1 1 2 2 2 0 Commissureless Ig_2 PF13895.6 PIK40202.1 - 1.3 9.4 8.2 2 8.8 0.8 3.8 3 2 0 3 3 3 0 Immunoglobulin domain Viral_Beta_CD PF04530.12 PIK40202.1 - 1.4 9.3 5.1 0.41 10.9 0.4 2.3 1 1 0 2 2 2 0 Viral Beta C/D like family Cadherin_C_2 PF16492.5 PIK40203.1 - 0.25 12.1 0.0 0.25 12.1 0.0 2.6 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Sushi PF00084.20 PIK40204.1 - 4.7e-05 23.9 0.2 4.7e-05 23.9 0.2 3.1 3 1 1 4 4 4 1 Sushi repeat (SCR repeat) fn3 PF00041.21 PIK40205.1 - 7e-23 80.8 3.2 9.1e-09 35.5 0.0 4.6 3 2 0 3 3 3 3 Fibronectin type III domain fn3_2 PF16893.5 PIK40205.1 - 6.1e-07 29.5 0.1 0.018 15.2 0.0 3.4 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK40205.1 - 0.0018 18.8 4.3 4.6 7.9 0.1 4.8 3 3 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK40205.1 - 0.0047 17.3 0.0 14 6.1 0.0 3.9 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Proteasom_PSMB PF10508.9 PIK40205.1 - 0.076 11.5 0.1 6 5.3 0.0 2.9 2 2 1 3 3 3 0 Proteasome non-ATPase 26S subunit SCAN PF02023.17 PIK40206.1 - 6.3e-05 22.7 0.0 0.00013 21.7 0.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-CCHC_3 PF13917.6 PIK40206.1 - 0.00018 21.4 0.0 0.00044 20.2 0.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK40206.1 - 0.00025 21.0 2.9 0.00049 20.0 2.9 1.5 1 0 0 1 1 1 1 Zinc knuckle RT_RNaseH PF17917.1 PIK40207.1 - 1.3e-39 134.7 0.0 2.3e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40207.1 - 2.3e-36 123.8 0.0 4.3e-36 123.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40207.1 - 3.4e-25 88.9 0.1 6e-25 88.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.29 PIK40207.1 - 4.5e-07 29.7 10.6 7.4e-07 29.0 9.2 2.2 2 1 0 2 2 2 1 PHD-finger FGAR-AT_linker PF18072.1 PIK40207.1 - 0.00061 20.3 0.0 18 6.0 0.0 3.6 3 0 0 3 3 3 2 Formylglycinamide ribonucleotide amidotransferase linker domain zf-CW PF07496.15 PIK40207.1 - 4.4 7.4 9.1 8.1 6.6 8.0 2.1 2 1 0 2 2 2 0 CW-type Zinc Finger SCAI PF12070.8 PIK40208.1 - 3.5e-160 534.4 19.1 3.1e-126 422.4 4.3 2.9 1 1 1 2 2 2 2 Protein SCAI p450 PF00067.22 PIK40209.1 - 4.4e-43 147.7 0.1 4.7e-43 147.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 PIK40212.1 - 6.1e-58 196.2 0.0 2.7e-56 190.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40212.1 - 4e-28 98.4 0.0 5.8e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK40212.1 - 2.3e-05 23.5 0.0 0.00081 18.4 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK40212.1 - 0.00088 18.7 0.0 0.0026 17.2 0.0 1.7 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK40212.1 - 0.0078 15.6 0.0 0.034 13.5 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK40212.1 - 0.046 13.6 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 PIK40212.1 - 0.13 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Frizzled PF01534.17 PIK40213.1 - 6.5e-134 446.1 14.3 8.2e-134 445.7 14.3 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 PIK40213.1 - 1.8e-31 109.1 2.5 1.8e-31 109.1 2.5 1.7 2 0 0 2 2 2 1 Fz domain 7TM_GPCR_Srsx PF10320.9 PIK40213.1 - 0.018 14.5 6.0 0.042 13.2 6.0 1.6 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Homeodomain PF00046.29 PIK40214.1 - 8.4e-08 31.9 3.3 8.4e-08 31.9 3.3 2.0 2 0 0 2 2 2 1 Homeodomain Lectin_C PF00059.21 PIK40215.1 - 3.7e-05 24.4 0.0 3.7e-05 24.4 0.0 2.2 3 0 0 3 3 3 1 Lectin C-type domain RCR PF12273.8 PIK40215.1 - 0.073 13.7 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red EGF PF00008.27 PIK40215.1 - 0.098 13.0 37.5 0.21 11.9 0.5 5.4 5 0 0 5 5 5 0 EGF-like domain Lectin_C PF00059.21 PIK40216.1 - 1e-09 39.1 2.5 1.5e-09 38.5 0.0 2.4 2 0 0 2 2 2 1 Lectin C-type domain cEGF PF12662.7 PIK40216.1 - 1.1e-06 28.4 34.9 0.0057 16.6 1.6 6.3 5 1 0 5 5 5 4 Complement Clr-like EGF-like EGF PF00008.27 PIK40216.1 - 1.2e-06 28.7 46.0 0.0035 17.6 3.4 6.2 4 2 1 5 5 5 4 EGF-like domain FXa_inhibition PF14670.6 PIK40216.1 - 8.4e-06 26.0 52.8 0.011 16.0 3.0 5.9 4 1 1 5 5 5 5 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK40216.1 - 0.0012 18.9 64.5 0.096 12.9 9.4 6.4 4 2 2 6 6 6 4 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 PIK40216.1 - 0.0039 17.2 35.7 0.21 11.7 1.9 5.9 5 0 0 5 5 5 4 MSP1 EGF domain 1 EB PF01683.18 PIK40216.1 - 0.0092 16.3 10.4 0.0092 16.3 10.4 6.1 3 2 3 6 6 6 3 EB module hEGF PF12661.7 PIK40216.1 - 0.027 15.1 0.5 0.027 15.1 0.5 7.8 9 0 0 9 9 9 0 Human growth factor-like EGF STAT_bind PF02864.15 PIK40217.1 - 5.1e-49 166.2 1.0 5.1e-49 166.2 1.0 2.4 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.20 PIK40217.1 - 2.9e-44 151.0 23.6 4.4e-44 150.4 23.6 1.2 1 0 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.24 PIK40217.1 - 1.3e-11 44.4 0.0 4.5e-11 42.7 0.0 1.9 1 0 0 1 1 1 1 SH2 domain STATa_Ig PF18214.1 PIK40217.1 - 0.00021 21.3 0.2 0.00021 21.3 0.2 2.5 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain DUF2379 PF09543.10 PIK40217.1 - 0.055 13.7 0.0 0.33 11.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) Porphyrn_cat_1 PF18206.1 PIK40217.1 - 1 10.0 7.6 2.7 8.7 7.6 1.7 1 0 0 1 1 1 0 Porphyranase catalytic subdomain 1 RVT_1 PF00078.27 PIK40219.1 - 8e-13 48.4 0.6 2.7e-12 46.7 0.4 2.1 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_S66 PF02016.15 PIK40219.1 - 0.043 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain HECT PF00632.25 PIK40220.1 - 2.2e-12 47.1 0.0 1.3e-06 28.1 0.0 2.1 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) RVT_1 PF00078.27 PIK40221.1 - 0.0039 16.7 0.0 0.0071 15.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK40222.1 - 2.5e-23 82.7 0.0 3.3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK40222.1 - 0.19 11.7 0.0 0.3 11.1 0.0 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Ig_3 PF13927.6 PIK40223.1 - 1.5e-05 25.5 0.3 0.00087 19.8 0.1 2.1 1 1 1 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40223.1 - 2.3e-05 24.7 0.3 6.8e-05 23.1 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain C1-set PF07654.15 PIK40223.1 - 0.0006 20.2 0.1 0.0021 18.4 0.1 1.7 1 1 1 2 2 2 1 Immunoglobulin C1-set domain ig PF00047.25 PIK40223.1 - 0.0011 19.1 0.1 0.033 14.4 0.1 2.1 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK40223.1 - 0.013 15.5 0.2 0.026 14.6 0.2 1.4 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK40223.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40225.1 - 7.6e-15 55.3 3.3 4.4e-08 33.6 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK40225.1 - 1.3e-10 41.5 6.5 5.2e-05 23.5 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK40225.1 - 3.1e-10 40.1 0.7 4.4e-06 26.8 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK40225.1 - 3.2e-10 39.9 0.2 1.5e-07 31.4 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK40225.1 - 2e-07 31.2 1.9 7.8e-06 26.0 0.1 3.0 3 0 0 3 3 3 1 Immunoglobulin V-set domain BslA PF17735.1 PIK40225.1 - 0.00062 19.7 0.0 0.24 11.4 0.0 2.8 2 1 0 3 3 3 1 Biofilm surface layer A Ig_5 PF16681.5 PIK40225.1 - 0.0021 18.4 0.1 0.68 10.4 0.1 3.2 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK40225.1 - 0.0021 18.1 1.9 1.8 8.7 0.1 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain COX7B PF05392.11 PIK40225.1 - 0.04 13.6 0.8 0.42 10.3 0.1 2.7 2 1 0 2 2 2 0 Cytochrome C oxidase chain VIIB Ubiquitin_3 PF14836.6 PIK40225.1 - 0.1 12.6 0.1 1.2 9.2 0.0 2.7 3 1 0 3 3 3 0 Ubiquitin-like domain Aldolase_II PF00596.21 PIK40227.1 - 4e-10 39.9 0.0 4.3e-10 39.8 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain RINGv PF12906.7 PIK40230.1 - 8.2e-14 51.5 13.6 1.2e-13 50.9 13.6 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 PIK40230.1 - 0.022 15.1 11.2 0.044 14.1 11.2 1.6 1 0 0 1 1 1 0 Ring finger domain PHD_4 PF16866.5 PIK40230.1 - 0.048 13.8 8.4 0.95 9.6 0.7 2.3 1 1 1 2 2 2 0 PHD-finger PHD PF00628.29 PIK40230.1 - 0.64 10.0 11.3 1.6 8.7 3.2 2.6 1 1 1 2 2 2 0 PHD-finger FANCL_C PF11793.8 PIK40230.1 - 1.7 8.8 9.6 1 9.6 6.3 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain TED_complement PF07678.14 PIK40231.1 - 3.9e-76 256.1 0.1 2.1e-40 138.7 0.0 2.6 1 1 1 2 2 2 2 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK40231.1 - 8.3e-32 110.5 5.8 1.4e-29 103.2 1.7 3.9 3 1 0 3 3 3 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK40231.1 - 4.5e-29 100.1 0.8 1.4e-28 98.6 0.5 2.1 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 PIK40231.1 - 5.9e-24 84.6 0.6 2.9e-23 82.4 0.6 2.3 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG2 PF01835.19 PIK40231.1 - 1.2e-13 51.3 0.0 1.6e-12 47.7 0.0 2.9 3 0 0 3 3 3 1 MG2 domain MG3 PF17791.1 PIK40231.1 - 7.7e-09 35.7 0.0 1.4e-07 31.7 0.0 2.9 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK40231.1 - 1.7e-05 24.9 1.4 0.024 14.8 0.0 4.4 3 2 0 3 3 3 1 Macroglobulin domain MG4 MG1 PF17790.1 PIK40231.1 - 0.035 14.5 0.0 0.26 11.7 0.0 2.5 1 0 0 1 1 1 0 Macroglobulin domain MG1 CAP PF00188.26 PIK40232.1 - 6.5e-20 72.2 5.2 1.3e-19 71.3 5.2 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Cadherin PF00028.17 PIK40233.1 - 1.3e-09 38.3 0.6 3.8e-05 24.1 0.0 3.1 2 1 0 2 2 2 2 Cadherin domain Cadherin PF00028.17 PIK40234.1 - 7.7e-75 247.4 2.5 1.9e-19 69.9 0.0 7.3 6 1 1 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 PIK40234.1 - 1.2e-05 25.0 0.0 1.5 8.7 0.0 4.6 5 0 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.5 PIK40234.1 - 2e-05 24.5 7.5 4.6 7.3 0.1 6.3 6 1 1 7 7 7 3 Cadherin-like Cadherin_pro PF08758.11 PIK40234.1 - 0.074 13.2 0.0 0.77 10.0 0.0 2.8 3 0 0 3 3 3 0 Cadherin prodomain like Cadherin PF00028.17 PIK40235.1 - 5.8e-177 574.8 34.9 6.3e-20 71.4 0.5 14.1 14 0 0 14 14 14 13 Cadherin domain Cadherin_2 PF08266.12 PIK40235.1 - 6e-09 35.6 4.2 1.1 9.1 0.0 8.7 11 0 0 11 11 11 2 Cadherin-like Cadherin_pro PF08758.11 PIK40235.1 - 6.7e-05 23.0 1.9 0.0037 17.4 0.1 4.9 6 0 0 6 6 6 1 Cadherin prodomain like Y_Y_Y PF07495.13 PIK40235.1 - 0.00015 21.7 0.1 1.5 8.8 0.1 5.5 5 0 0 5 5 5 1 Y_Y_Y domain PepSY PF03413.19 PIK40235.1 - 0.0002 21.9 12.8 14 6.3 0.1 8.1 8 0 0 8 8 8 2 Peptidase propeptide and YPEB domain Cadherin PF00028.17 PIK40236.1 - 2.1e-53 178.8 3.0 4.3e-17 62.3 1.0 4.2 4 0 0 4 4 4 4 Cadherin domain Cadherin_3 PF16184.5 PIK40236.1 - 4.6e-07 29.8 3.2 0.00021 21.3 0.3 3.1 3 0 0 3 3 3 2 Cadherin-like Cadherin_2 PF08266.12 PIK40236.1 - 1.5e-06 27.9 0.0 0.22 11.4 0.0 3.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_4 PF17803.1 PIK40236.1 - 0.016 15.8 15.6 0.027 15.1 1.9 3.4 2 1 0 3 3 3 0 Bacterial cadherin-like domain Hexapep_2 PF14602.6 PIK40236.1 - 0.086 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Cadherin_pro PF08758.11 PIK40236.1 - 0.12 12.5 0.0 2.7 8.2 0.0 3.0 4 0 0 4 4 4 0 Cadherin prodomain like Calx-beta PF03160.14 PIK40236.1 - 6.6 7.0 9.4 5.6 7.2 2.1 3.9 3 1 1 4 4 4 0 Calx-beta domain Cadherin PF00028.17 PIK40237.1 - 3.9e-64 213.1 7.3 8.5e-21 74.2 0.0 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_3 PF16184.5 PIK40237.1 - 1.2e-07 31.7 5.3 0.00062 19.8 0.0 4.0 3 1 1 4 4 4 2 Cadherin-like Cadherin_2 PF08266.12 PIK40237.1 - 0.0045 16.8 0.0 10 6.0 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like PCC_BT PF18140.1 PIK40237.1 - 0.0095 16.3 0.1 0.063 13.6 0.0 2.3 2 1 1 3 3 3 1 Propionyl-coenzyme A carboxylase BT domain Laminin_G_2 PF02210.24 PIK40238.1 - 8.1e-26 91.1 0.1 1.2e-25 90.5 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK40238.1 - 1.8e-24 86.4 0.0 2.6e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 PIK40238.1 - 1.7e-14 53.8 82.9 1.4e-08 34.8 12.9 7.2 8 0 0 8 8 7 4 EGF-like domain Laminin_G_3 PF13385.6 PIK40238.1 - 8e-08 32.6 0.1 1.1e-07 32.1 0.1 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.7 PIK40238.1 - 1.8e-05 25.1 8.7 1.8e-05 25.1 8.7 7.5 9 0 0 9 9 7 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK40238.1 - 0.00048 20.4 12.7 0.00048 20.4 12.7 5.7 6 0 0 6 6 6 2 EGF-like domain EphA2_TM PF14575.6 PIK40238.1 - 0.0078 17.1 0.0 0.017 16.0 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Stevor PF17410.2 PIK40238.1 - 0.047 13.2 0.0 0.079 12.5 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 PIK40238.1 - 0.064 13.2 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK40238.1 - 0.098 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Protocadherin PF08374.11 PIK40238.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protocadherin RCR PF12273.8 PIK40238.1 - 0.14 12.8 0.0 0.27 11.9 0.0 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.15 PIK40238.1 - 0.37 10.6 2.1 0.73 9.7 2.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CcmD PF04995.14 PIK40238.1 - 1.3 9.2 6.3 2 8.5 6.3 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Pkinase_Tyr PF07714.17 PIK40239.1 - 2.5e-98 328.5 0.0 3.4e-98 328.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK40239.1 - 5.7e-57 190.3 12.6 1.4e-12 48.0 0.1 8.4 7 1 1 8 8 8 7 Immunoglobulin domain I-set PF07679.16 PIK40239.1 - 3.8e-51 171.1 1.5 3.2e-12 46.3 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK40239.1 - 2.5e-41 139.9 16.2 1.6e-12 47.6 0.0 8.4 8 1 0 8 8 8 6 Immunoglobulin domain ig PF00047.25 PIK40239.1 - 3.1e-39 133.0 7.1 7.2e-11 42.1 0.0 8.8 8 2 0 8 8 8 5 Immunoglobulin domain Pkinase PF00069.25 PIK40239.1 - 4.1e-38 131.3 0.0 3.1e-24 85.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain C2-set_2 PF08205.12 PIK40239.1 - 5.3e-12 45.6 0.4 0.02 15.0 0.0 5.9 6 1 0 6 6 6 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK40239.1 - 6e-12 45.7 18.7 0.0062 16.7 0.3 8.2 7 2 0 7 7 7 2 Immunoglobulin V-set domain Adeno_E3_CR1 PF02440.15 PIK40239.1 - 0.00036 20.3 2.2 0.031 14.1 0.2 3.9 4 1 0 4 4 4 1 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.5 PIK40239.1 - 0.0014 18.6 5.3 18 5.4 0.1 6.0 7 0 0 7 7 7 0 Izumo-like Immunoglobulin domain Haspin_kinase PF12330.8 PIK40239.1 - 0.14 11.1 0.1 0.26 10.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain LysM PF01476.20 PIK40240.1 - 1.4e-07 31.5 0.0 2.9e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 LysM domain AAA_27 PF13514.6 PIK40240.1 - 0.33 10.5 3.6 1.2 8.7 0.6 2.3 2 0 0 2 2 2 0 AAA domain Sulfotransfer_2 PF03567.14 PIK40241.1 - 5.3e-43 147.7 1.4 5.3e-43 147.7 1.4 1.5 2 0 0 2 2 2 1 Sulfotransferase family DUF3659 PF12396.8 PIK40241.1 - 0.12 12.3 0.8 0.43 10.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) SR-25 PF10500.9 PIK40241.1 - 0.51 9.9 7.0 0.91 9.1 7.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sulfotransfer_2 PF03567.14 PIK40242.1 - 3.9e-47 161.3 2.8 4.7e-47 161.0 2.8 1.1 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_M60 PF13402.6 PIK40242.1 - 0.0071 15.9 1.8 0.052 13.1 0.0 2.1 1 1 1 2 2 2 1 Peptidase M60, enhancin and enhancin-like zf-H2C2_2 PF13465.6 PIK40243.1 - 4.2e-36 121.8 74.4 5.8e-06 26.5 2.5 11.2 11 0 0 11 11 11 9 Zinc-finger double domain zf-H2C2_5 PF13909.6 PIK40243.1 - 2.8e-32 110.1 66.4 1.2e-07 31.4 1.4 9.1 9 0 0 9 9 9 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK40243.1 - 7e-18 64.0 81.5 0.00012 22.4 1.7 10.1 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK40243.1 - 1.4e-12 47.3 74.9 0.026 15.4 1.2 9.8 10 0 0 10 10 10 8 C2H2-type zinc finger Cmc1 PF08583.10 PIK40244.1 - 7e-20 70.8 7.3 9.8e-20 70.3 7.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 PIK40244.1 - 0.042 14.0 6.8 1.9 8.7 0.1 2.8 3 0 0 3 3 3 0 CHCH domain MNNL PF07657.13 PIK40244.1 - 0.22 11.6 6.2 0.46 10.5 5.4 1.8 1 1 1 2 2 2 0 N terminus of Notch ligand MTCP1 PF08991.10 PIK40244.1 - 0.82 10.0 6.8 1.5 9.1 0.4 2.4 2 1 0 2 2 2 0 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 PIK40244.1 - 1.2 9.5 12.0 13 6.2 1.0 3.0 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DUF3128 PF11326.8 PIK40244.1 - 4.4 7.8 8.0 27 5.2 8.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) VHS PF00790.19 PIK40245.1 - 2.4e-32 111.7 0.1 4.7e-32 110.8 0.1 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 PIK40245.1 - 6.3e-16 57.7 0.1 1.1e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK40245.1 - 5.3e-12 45.2 0.0 9.2e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK40245.1 - 1.9e-09 37.2 0.1 3.4e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 PIK40245.1 - 0.004 17.2 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain DUF859 PF05895.12 PIK40245.1 - 0.0088 14.6 0.1 0.013 14.1 0.1 1.1 1 0 0 1 1 1 1 Siphovirus protein of unknown function (DUF859) NMD3 PF04981.13 PIK40246.1 - 7.3e-74 248.3 5.7 1.2e-73 247.6 5.7 1.4 1 0 0 1 1 1 1 NMD3 family CLAMP PF14769.6 PIK40246.1 - 0.0095 16.4 0.9 0.021 15.3 0.9 1.6 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 COPIIcoated_ERV PF07970.12 PIK40246.1 - 0.06 13.2 2.7 0.12 12.2 2.7 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter Kinesin PF00225.23 PIK40247.1 - 6.3e-109 363.9 0.4 8.8e-109 363.4 0.4 1.1 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 PIK40247.1 - 8e-25 88.0 8.3 2.8e-18 66.7 0.4 3.1 2 1 1 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 PIK40247.1 - 1.3e-21 77.1 0.0 2.8e-21 76.0 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.26 PIK40247.1 - 5.2e-08 33.1 0.0 1.7e-06 28.3 0.0 3.0 3 0 0 3 3 3 1 FHA domain GAS PF13851.6 PIK40247.1 - 0.00027 20.4 2.3 0.00043 19.7 2.3 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Spexin PF15171.6 PIK40248.1 - 0.12 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Neuropeptide secretory protein family, NPQ, spexin DUF4405 PF14358.6 PIK40249.1 - 0.08 13.5 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4405) NHL PF01436.21 PIK40250.1 - 0.0022 17.9 0.1 2.2 8.5 0.0 4.1 3 0 0 3 3 3 1 NHL repeat C2-set_2 PF08205.12 PIK40250.1 - 0.0028 17.7 0.1 0.2 11.8 0.1 2.8 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK40251.1 - 2e-11 44.1 0.0 3.9e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK40251.1 - 0.00076 19.1 0.0 0.002 17.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain GPI2 PF06432.11 PIK40251.1 - 0.0032 17.0 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase THAP PF05485.12 PIK40252.1 - 1e-15 58.4 0.1 1.4e-15 57.9 0.1 1.2 1 0 0 1 1 1 1 THAP domain GTPase_binding PF09027.10 PIK40252.1 - 0.064 13.2 0.3 0.5 10.4 0.2 2.3 2 1 1 3 3 3 0 GTPase binding Noc2 PF03715.13 PIK40253.1 - 0.01 15.1 0.0 0.011 15.0 0.0 1.0 1 0 0 1 1 1 1 Noc2p family Lep_receptor_Ig PF06328.11 PIK40253.1 - 0.085 12.8 0.0 0.095 12.7 0.0 1.1 1 0 0 1 1 1 0 Ig-like C2-type domain MA3 PF02847.17 PIK40254.1 - 9.9e-21 73.8 0.5 2e-20 72.8 0.5 1.6 1 0 0 1 1 1 1 MA3 domain MA3 PF02847.17 PIK40255.1 - 8.4e-21 74.1 0.5 1.4e-20 73.4 0.5 1.3 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 PIK40256.1 - 9.8e-12 45.0 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain Cdc6_C PF09079.11 PIK40258.1 - 1.9e-16 59.8 0.3 5e-16 58.4 0.3 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_22 PF13401.6 PIK40258.1 - 2.1e-15 57.2 0.0 4.4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK40258.1 - 2.1e-11 44.5 0.6 1.3e-09 38.6 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 PIK40258.1 - 3.5e-11 43.6 0.0 6.5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 PIK40258.1 - 2.5e-08 34.0 1.0 8.4e-08 32.3 0.2 2.3 2 0 0 2 2 2 1 AAA lid domain TniB PF05621.11 PIK40258.1 - 6.6e-05 22.4 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein Torsin PF06309.11 PIK40258.1 - 0.00064 19.8 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Torsin NACHT PF05729.12 PIK40258.1 - 0.001 19.1 0.0 0.0029 17.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK40258.1 - 0.0019 17.4 0.5 0.0033 16.7 0.1 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA_19 PF13245.6 PIK40258.1 - 0.0023 18.3 0.1 0.0093 16.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 PIK40258.1 - 0.0047 17.0 0.0 5.1 7.2 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activat PF00158.26 PIK40258.1 - 0.011 15.4 0.0 0.065 12.9 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 PIK40258.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK40258.1 - 0.061 13.2 0.1 0.16 11.9 0.1 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK40258.1 - 0.063 12.8 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region SSPI PF14098.6 PIK40260.1 - 0.0075 16.4 1.2 0.086 13.0 0.0 2.8 2 1 1 3 3 3 1 Small, acid-soluble spore protein I Hira PF07569.11 PIK40260.1 - 0.067 12.9 4.5 0.084 12.6 4.5 1.1 1 0 0 1 1 1 0 TUP1-like enhancer of split VPR PF00522.18 PIK40260.1 - 0.069 13.2 2.5 0.35 10.9 0.8 2.1 1 1 1 2 2 2 0 VPR/VPX protein Endonuc_Holl PF10107.9 PIK40260.1 - 2.2 8.1 8.3 1.6 8.6 5.8 1.7 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Kinesin PF00225.23 PIK40261.1 - 1.5e-51 175.3 1.0 3e-51 174.3 1.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Mvb12 PF09452.10 PIK40261.1 - 0.014 15.8 2.7 0.029 14.8 1.4 2.2 1 1 0 1 1 1 0 ESCRT-I subunit Mvb12 DUF4748 PF15932.5 PIK40261.1 - 0.16 11.7 1.1 0.4 10.5 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Kinesin PF00225.23 PIK40262.1 - 8.1e-37 126.9 0.2 9.6e-37 126.6 0.2 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK40262.1 - 3.8e-26 91.8 0.6 5e-26 91.4 0.6 1.1 1 0 0 1 1 1 1 Microtubule binding AAA_30 PF13604.6 PIK40262.1 - 0.00043 20.0 0.0 0.00061 19.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK40262.1 - 0.0014 18.2 0.2 0.0026 17.3 0.0 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK40262.1 - 0.0065 16.7 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK40262.1 - 0.0075 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit APOBEC3 PF18771.1 PIK40262.1 - 0.0081 16.3 0.0 0.022 14.9 0.0 1.6 2 0 0 2 2 2 1 APOBEC3 AAA_16 PF13191.6 PIK40262.1 - 0.013 15.8 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 PIK40262.1 - 0.041 13.9 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SNAD4 PF18750.1 PIK40262.1 - 0.12 12.5 0.0 3.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 DHC_N1 PF08385.12 PIK40264.1 - 0.0088 14.7 2.8 0.012 14.3 2.8 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Prominin PF05478.11 PIK40264.1 - 0.014 13.4 5.4 0.018 13.1 5.4 1.1 1 0 0 1 1 1 0 Prominin IBN_N PF03810.19 PIK40264.1 - 0.041 13.8 0.4 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 Importin-beta N-terminal domain SOAR PF16533.5 PIK40264.1 - 0.041 13.9 5.6 0.084 12.8 5.4 1.7 1 1 0 1 1 1 0 STIM1 Orai1-activating region CwfJ_C_1 PF04677.15 PIK40264.1 - 0.041 13.7 0.1 0.14 12.1 0.1 1.9 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 1 GCR1_C PF12550.8 PIK40264.1 - 0.056 13.8 1.1 0.4 11.0 0.2 2.4 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Ku_PK_bind PF08785.11 PIK40264.1 - 0.059 13.5 3.3 0.12 12.6 3.2 1.5 1 1 0 1 1 1 0 Ku C terminal domain like Acyl-CoA_dh_N PF02771.16 PIK40264.1 - 0.16 12.6 0.1 0.28 11.9 0.1 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain ATG16 PF08614.11 PIK40264.1 - 0.17 12.1 8.8 0.39 10.9 8.7 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CK2S PF15011.6 PIK40264.1 - 0.44 10.4 5.2 0.44 10.4 0.9 2.1 1 1 1 2 2 2 0 Casein Kinase 2 substrate DUF2115 PF09888.9 PIK40264.1 - 0.44 11.0 3.7 0.7 10.4 3.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) K-box PF01486.17 PIK40264.1 - 0.93 9.7 9.5 3.4 7.9 7.4 2.3 1 1 1 2 2 2 0 K-box region DUF948 PF06103.11 PIK40264.1 - 2.1 8.7 4.3 1.7e+02 2.5 4.3 2.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF2203 PF09969.9 PIK40264.1 - 2.9 8.6 6.7 4.1 8.1 1.2 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Latarcin PF10279.9 PIK40264.1 - 3.6 8.1 8.3 1.9e+02 2.5 8.2 2.4 1 1 0 1 1 1 0 Latarcin precursor Cgr1 PF03879.14 PIK40264.1 - 4.2 7.8 9.2 0.51 10.7 0.9 2.1 1 1 1 2 2 2 0 Cgr1 family PHD PF00628.29 PIK40266.1 - 9.4e-07 28.6 9.6 3.1e-06 27.0 9.6 1.9 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 PIK40266.1 - 0.011 15.7 2.9 0.011 15.7 2.9 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ig PF00047.25 PIK40266.1 - 0.018 15.2 0.0 0.048 13.9 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK40266.1 - 0.019 15.6 0.0 0.056 14.1 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain C1_1 PF00130.22 PIK40266.1 - 0.02 14.8 9.2 0.021 14.7 4.7 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ig_2 PF13895.6 PIK40266.1 - 0.039 14.3 0.1 0.12 12.7 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain PHD_2 PF13831.6 PIK40266.1 - 0.046 13.3 0.0 0.046 13.3 0.0 2.7 3 0 0 3 3 2 0 PHD-finger DUF2203 PF09969.9 PIK40266.1 - 0.15 12.8 3.3 13 6.5 0.8 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Zf_RING PF16744.5 PIK40266.1 - 0.45 10.7 6.8 0.85 9.8 5.6 2.1 1 1 1 2 2 2 0 KIAA1045 RING finger Basic PF01586.16 PIK40266.1 - 1.6 10.0 9.9 0.66 11.2 6.2 2.5 2 1 0 2 2 1 0 Myogenic Basic domain C1_2 PF03107.16 PIK40266.1 - 8 6.9 10.1 28 5.1 4.9 3.0 3 0 0 3 3 3 0 C1 domain RVT_1 PF00078.27 PIK40267.1 - 1.7e-24 86.6 0.0 2.7e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RIFIN PF02009.16 PIK40267.1 - 0.00078 19.4 1.2 0.0011 18.9 1.2 1.2 1 0 0 1 1 1 1 Rifin DUF3149 PF11346.8 PIK40267.1 - 2.5 7.8 8.8 5.1 6.8 8.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Ig_3 PF13927.6 PIK40268.1 - 9.1e-06 26.2 0.2 0.0013 19.2 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40268.1 - 2.4e-05 24.6 0.6 0.0016 18.7 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK40268.1 - 0.0046 17.1 0.3 0.021 15.0 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK40268.1 - 0.014 15.5 0.3 0.085 13.0 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Fibrinogen_C PF00147.18 PIK40269.1 - 1.2e-25 90.6 0.8 1.3e-25 90.5 0.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK40270.1 - 9.8e-26 90.9 0.0 1.2e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK40270.1 - 6e-08 32.8 12.5 9.2e-08 32.2 12.5 1.3 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK40271.1 - 1.3e-35 123.2 2.4 1.3e-35 123.2 2.4 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK40271.1 - 4.1e-08 33.0 13.0 4.1e-08 33.0 13.0 3.7 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK40271.1 - 5.1e-07 29.8 17.4 5.1e-07 29.8 17.4 3.3 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK40271.1 - 0.03 14.4 9.6 0.03 14.4 9.6 3.6 4 0 0 4 4 4 0 MSP1 EGF domain 1 EGF_3 PF12947.7 PIK40271.1 - 0.034 14.3 15.2 0.034 14.3 15.2 4.2 2 2 1 3 3 3 0 EGF domain NUC194 PF08163.12 PIK40271.1 - 0.27 10.1 2.6 0.37 9.7 2.6 1.2 1 0 0 1 1 1 0 NUC194 domain Fibrinogen_C PF00147.18 PIK40272.1 - 1.3e-68 231.1 20.5 8.8e-38 130.3 0.4 2.3 1 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK40272.1 - 8e-08 32.4 16.0 8e-08 32.4 16.0 3.5 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK40272.1 - 2.6e-07 30.5 5.3 2.6e-07 30.5 5.3 4.7 3 1 2 5 5 5 1 TILa domain MDM1 PF15501.6 PIK40273.1 - 7.3e-38 131.0 18.6 1.2e-27 97.4 9.4 2.1 1 1 1 2 2 2 2 Nuclear protein MDM1 Bd3614_N PF14442.6 PIK40273.1 - 0.1 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal RR_TM4-6 PF06459.12 PIK40273.1 - 0.11 12.2 3.1 0.15 11.9 3.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Dynein_C PF18199.1 PIK40274.1 - 4.9e-117 390.5 0.0 6.9e-117 390.1 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 PIK40274.1 - 1.4e-46 157.4 0.0 3.6e-46 156.1 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 PIK40274.1 - 5.5e-28 97.8 0.1 4e-25 88.5 0.0 2.5 1 1 1 2 2 2 2 Dynein heavy chain AAA lid domain AAA_6 PF12774.7 PIK40275.1 - 5.4e-160 531.7 0.0 8.4e-158 524.5 0.0 2.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK40275.1 - 2.5e-118 395.7 2.7 2.5e-118 395.7 2.7 2.5 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK40275.1 - 5e-108 360.3 0.0 4.1e-107 357.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK40275.1 - 5.3e-86 287.3 0.2 5.3e-86 287.3 0.2 3.3 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 PIK40275.1 - 1.2e-85 285.5 0.1 4.8e-83 277.1 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region MT PF12777.7 PIK40275.1 - 6.5e-44 150.4 10.4 1.1e-43 149.6 10.4 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 PIK40275.1 - 2.3e-35 121.5 0.1 8.4e-35 119.7 0.1 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK40275.1 - 2.5e-20 72.9 0.0 1.8e-06 28.0 0.0 6.3 6 1 0 6 6 5 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 PIK40275.1 - 5.8e-19 68.2 0.3 2.9e-18 65.9 0.3 2.3 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 PIK40275.1 - 4.7e-07 30.3 0.0 0.32 11.4 0.0 4.4 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK40275.1 - 0.00011 22.5 0.0 0.82 10.0 0.0 4.7 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 PIK40275.1 - 0.00029 21.2 0.0 2.3 8.6 0.0 3.8 3 0 0 3 3 3 1 RNA helicase AAA_16 PF13191.6 PIK40275.1 - 0.00067 20.1 4.0 1 9.7 0.0 5.3 5 1 1 6 6 5 1 AAA ATPase domain AAA_33 PF13671.6 PIK40275.1 - 0.0016 18.7 0.0 0.75 9.9 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 PIK40275.1 - 0.0071 16.9 0.0 0.45 11.1 0.0 3.8 4 0 0 4 4 2 1 AAA domain AAA_24 PF13479.6 PIK40275.1 - 0.0073 16.0 0.4 3.5 7.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain Cytidylate_kin PF02224.18 PIK40275.1 - 0.0082 15.9 0.1 5 6.8 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase T2SSE PF00437.20 PIK40275.1 - 0.027 13.5 0.2 0.22 10.6 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein Phage_TAC_3 PF06896.11 PIK40275.1 - 0.031 14.8 0.5 0.031 14.8 0.5 2.9 3 0 0 3 3 1 0 Phage tail assembly chaperone proteins, TAC Borrelia_REV PF03978.13 PIK40275.1 - 0.042 13.8 1.6 0.2 11.6 1.6 2.2 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein AAA_29 PF13555.6 PIK40275.1 - 0.053 13.3 0.2 14 5.5 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 PIK40275.1 - 0.085 12.2 0.1 6.7 6.0 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Spc7 PF08317.11 PIK40275.1 - 0.12 11.2 17.5 0.12 11.2 6.0 2.6 2 0 0 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.12 PIK40275.1 - 0.69 10.4 3.8 1.3 9.6 0.2 3.5 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein GST_C PF00043.25 PIK40275.1 - 0.91 9.8 4.2 51 4.2 0.4 4.5 3 1 1 4 4 4 0 Glutathione S-transferase, C-terminal domain Laminin_II PF06009.12 PIK40275.1 - 4.5 7.3 13.5 0.13 12.2 1.6 3.4 3 0 0 3 3 2 0 Laminin Domain II MscS_porin PF12795.7 PIK40275.1 - 4.5 6.7 18.6 0.041 13.4 1.6 3.1 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain DHC_N2 PF08393.13 PIK40276.1 - 5.1e-09 35.7 1.8 5.1e-09 35.7 1.8 2.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 PTPRCAP PF15713.5 PIK40276.1 - 0.052 13.8 2.7 0.17 12.2 2.7 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Peptidase_M3_N PF08439.10 PIK40276.1 - 0.82 10.0 6.0 0.094 13.0 0.7 2.3 2 0 0 2 2 2 0 Oligopeptidase F ubiquitin PF00240.23 PIK40277.1 - 0.0027 17.4 0.0 0.014 15.2 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family GABP-alpha PF11620.8 PIK40277.1 - 0.0033 17.6 0.2 0.012 15.7 0.0 2.0 2 0 0 2 2 2 1 GA-binding protein alpha chain IQ PF00612.27 PIK40278.1 - 0.0024 17.5 0.7 0.0083 15.8 0.7 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif XPG_I_2 PF12813.7 PIK40278.1 - 0.058 12.9 2.2 1.4 8.3 0.0 3.5 3 1 1 4 4 4 0 XPG domain containing RNA_POL_M_15KD PF02150.16 PIK40278.1 - 0.06 13.2 0.3 0.13 12.1 0.3 1.6 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit 4HB_MCP_1 PF12729.7 PIK40278.1 - 0.23 11.0 7.0 0.37 10.3 3.8 2.4 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction CemA PF03040.14 PIK40278.1 - 0.66 9.9 3.1 2.3 8.1 0.5 2.3 2 0 0 2 2 2 0 CemA family Bap31 PF05529.12 PIK40279.1 - 5.3e-42 142.9 6.7 9.6e-42 142.1 6.7 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 PIK40279.1 - 7.2e-12 45.1 13.2 2e-11 43.7 13.2 1.8 1 1 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain APG6_N PF17675.1 PIK40279.1 - 0.0037 17.8 14.6 0.0057 17.2 14.6 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region UPF0242 PF06785.11 PIK40279.1 - 0.0054 16.8 5.1 0.009 16.1 5.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 PIK40279.1 - 0.021 13.7 10.8 0.029 13.3 10.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Wtap PF17098.5 PIK40279.1 - 0.03 14.3 8.3 0.066 13.1 8.4 1.5 1 1 0 1 1 1 0 WTAP/Mum2p family CENP-F_leu_zip PF10473.9 PIK40279.1 - 0.043 13.8 13.4 0.044 13.8 12.2 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 PIK40279.1 - 0.063 11.9 5.9 0.077 11.6 5.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PIG-U PF06728.13 PIK40279.1 - 0.074 12.1 3.3 0.11 11.5 3.3 1.2 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DUF4201 PF13870.6 PIK40279.1 - 0.13 12.0 11.9 0.028 14.2 6.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Cluap1 PF10234.9 PIK40279.1 - 0.16 11.3 11.5 0.49 9.7 10.6 1.8 1 1 1 2 2 2 0 Clusterin-associated protein-1 Renin_r PF07850.14 PIK40279.1 - 0.34 11.5 0.2 0.34 11.5 0.2 3.3 2 1 1 3 3 3 0 Renin receptor-like protein Cep57_CLD_2 PF14197.6 PIK40279.1 - 0.45 10.6 7.2 8.3 6.6 0.0 2.9 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 LRR19-TM PF15176.6 PIK40279.1 - 0.94 9.5 4.4 0.33 11.0 0.3 2.4 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain DUF948 PF06103.11 PIK40279.1 - 0.97 9.7 10.6 1.9 8.8 0.5 3.3 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3450 PF11932.8 PIK40279.1 - 1.2 8.4 11.1 0.54 9.5 5.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 PIK40279.1 - 1.2 9.3 13.3 2.5 8.3 7.4 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding COG2 PF06148.11 PIK40279.1 - 1.7 8.8 8.3 0.47 10.5 4.5 1.9 2 1 0 2 2 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4337 PF14235.6 PIK40279.1 - 2 8.5 10.3 23 5.1 9.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) YabA PF06156.13 PIK40279.1 - 2.7 8.7 7.1 1.6 9.4 4.5 1.9 2 0 0 2 2 2 0 Initiation control protein YabA KxDL PF10241.9 PIK40279.1 - 2.8 8.3 8.4 0.78 10.1 1.6 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein CENP-H PF05837.12 PIK40279.1 - 3.6 8.0 13.0 1.1 9.7 7.8 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Sec34 PF04136.15 PIK40279.1 - 4.5 7.2 10.5 1.4 8.8 6.3 2.0 2 0 0 2 2 2 0 Sec34-like family ATP-synt_E PF05680.12 PIK40279.1 - 6.7 7.1 9.3 1.3 9.4 4.3 2.1 1 1 1 2 2 2 0 ATP synthase E chain Ras PF00071.22 PIK40280.1 - 8.7e-40 136.0 0.0 1.1e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK40280.1 - 1.2e-26 93.3 0.0 1.7e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK40280.1 - 5.6e-13 48.7 0.0 7.3e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK40280.1 - 0.00042 19.7 0.0 0.00056 19.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK40280.1 - 0.002 18.2 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NPCBM PF08305.11 PIK40280.1 - 0.011 16.0 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 0 NPCBM/NEW2 domain DUF2072 PF09845.9 PIK40281.1 - 5.4 7.3 7.8 0.68 10.2 2.4 1.8 2 0 0 2 2 2 0 Zn-ribbon containing protein Hydrolase_4 PF12146.8 PIK40283.1 - 1e-50 172.3 0.0 4.9e-36 124.2 0.0 2.0 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK40283.1 - 4.7e-07 29.7 0.0 5.7e-06 26.2 0.0 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 PIK40283.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 PIK40283.1 - 0.021 15.4 0.0 0.032 14.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family LCAT PF02450.15 PIK40283.1 - 0.072 12.2 0.0 3 6.9 0.0 2.1 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.25 PIK40283.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 PIK40283.1 - 0.23 11.1 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Prok-E2_B PF14461.6 PIK40284.1 - 0.0001 22.0 3.0 1.6e+02 1.9 0.0 8.7 10 0 0 10 10 10 0 Prokaryotic E2 family B IKI3 PF04762.12 PIK40284.1 - 0.049 11.6 0.0 55 1.5 0.0 4.9 6 1 1 7 7 7 0 IKI3 family CAF1C_H4-bd PF12265.8 PIK40284.1 - 0.46 10.8 3.1 7.7 6.9 0.2 3.8 2 0 0 2 2 2 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex Nop16 PF09420.10 PIK40285.1 - 4.5e-20 72.6 12.5 1.4e-13 51.4 0.6 2.0 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Fungal_lectin_2 PF18647.1 PIK40285.1 - 0.043 14.3 0.5 0.097 13.1 0.1 1.8 1 1 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin Cast PF10174.9 PIK40286.1 - 1.6e-27 96.1 3.7 2.1e-27 95.7 3.7 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone LRR_6 PF13516.6 PIK40287.1 - 1.1e-35 118.6 39.7 0.00026 20.8 0.1 12.2 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.7 PIK40287.1 - 8.9e-22 76.8 35.3 8.2e-06 26.1 2.5 7.6 4 3 3 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK40287.1 - 1.3e-09 37.7 26.7 6.8e-05 22.6 2.9 6.5 4 2 2 6 6 6 4 Leucine rich repeat F-box-like PF12937.7 PIK40287.1 - 2.2e-09 37.1 0.1 7.9e-09 35.3 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 PIK40287.1 - 1.5e-07 30.9 36.4 0.51 11.1 0.1 11.3 11 1 0 11 11 11 3 Leucine Rich Repeat F-box PF00646.33 PIK40287.1 - 8.8e-05 22.3 0.0 8.8e-05 22.3 0.0 3.8 5 0 0 5 5 5 1 F-box domain LRR_2 PF07723.13 PIK40287.1 - 0.011 16.4 11.1 9 7.2 0.1 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat wnt PF00110.19 PIK40288.1 - 3.6e-117 391.4 22.7 4.1e-117 391.2 22.7 1.0 1 0 0 1 1 1 1 wnt family RT_RNaseH PF17917.1 PIK40291.1 - 7.4e-25 87.3 0.0 1.4e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40291.1 - 4.5e-21 74.8 0.0 8.2e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK40291.1 - 4.7e-20 72.0 0.0 1.1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK40291.1 - 0.0036 17.1 0.1 0.012 15.3 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK40292.1 - 5.1e-27 94.8 0.0 7.4e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4922 PF16269.5 PIK40292.1 - 0.14 11.9 0.0 0.81 9.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) SfsA_N PF17746.1 PIK40293.1 - 0.19 11.9 0.0 0.52 10.5 0.0 1.8 2 0 0 2 2 2 0 SfsA N-terminal OB domain Hormone_recep PF00104.30 PIK40294.1 - 2.3e-09 37.2 0.0 2.6e-09 37.0 0.0 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 PIK40295.1 - 1.6e-27 95.8 11.5 3.1e-27 94.8 11.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Prok-RING_1 PF14446.6 PIK40295.1 - 7.5 6.6 8.9 1.1 9.2 3.0 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Kringle PF00051.18 PIK40296.1 - 5.5e-32 109.9 17.5 1.9e-18 66.6 1.4 3.2 2 1 2 4 4 4 2 Kringle domain PAN_1 PF00024.26 PIK40296.1 - 3.6e-17 62.1 0.6 4.1e-09 36.3 0.0 2.7 2 0 0 2 2 2 2 PAN domain SRCR PF00530.18 PIK40297.1 - 1.6e-10 41.4 7.8 1.6e-10 41.4 7.8 2.0 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK40297.1 - 0.00043 20.7 0.3 0.00043 20.7 0.3 2.5 2 1 1 3 3 3 1 Scavenger receptor cysteine-rich domain Myticin-prepro PF10690.9 PIK40297.1 - 0.022 15.0 0.7 0.022 15.0 0.7 2.5 2 1 0 2 2 2 0 Myticin pre-proprotein from the mussel FAM176 PF14851.6 PIK40297.1 - 0.14 11.8 0.8 0.24 11.0 0.8 1.4 1 0 0 1 1 1 0 FAM176 family DED PF01335.21 PIK40298.1 - 3.1e-07 30.6 0.9 5.6e-07 29.8 0.9 1.4 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 PIK40298.1 - 4.7e-05 23.5 0.8 0.0012 18.9 0.2 2.2 2 0 0 2 2 2 1 Death domain DbpA PF03880.15 PIK40298.1 - 0.053 13.5 0.3 0.12 12.4 0.2 1.6 2 0 0 2 2 2 0 DbpA RNA binding domain LRR_8 PF13855.6 PIK40300.1 - 4.3e-30 103.3 11.9 2.2e-15 56.1 0.2 3.8 2 2 1 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 PIK40300.1 - 1.2e-14 54.3 1.0 5.8e-07 29.5 0.0 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40300.1 - 2e-10 40.7 20.8 0.0015 18.9 0.1 4.6 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK40300.1 - 2e-05 24.5 23.2 9.1 7.3 0.1 7.8 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK40300.1 - 0.0023 17.4 3.9 1.8 8.0 0.0 2.4 2 0 0 2 2 2 2 Leucine-rich repeat Mycobact_memb PF05423.13 PIK40300.1 - 0.099 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Mycobacterium membrane protein Sulfotransfer_3 PF13469.6 PIK40301.1 - 0.0077 16.6 0.1 0.011 16.1 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_M1 PF01433.20 PIK40302.1 - 8.1e-86 287.1 2.1 1.5e-85 286.2 2.1 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 PIK40302.1 - 4.8e-68 230.0 3.6 8.3e-68 229.3 3.6 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 PIK40302.1 - 4.1e-40 138.0 0.0 7e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Laminin_EGF PF00053.24 PIK40304.1 - 6.4e-81 266.3 186.3 6.4e-11 42.2 14.4 11.4 10 1 1 11 11 11 11 Laminin EGF domain Laminin_N PF00055.17 PIK40304.1 - 3.1e-16 59.7 0.0 3.1e-16 59.7 0.0 4.8 4 1 1 5 5 5 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK40304.1 - 2.6e-15 56.5 0.0 4.4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Laminin B (Domain IV) RT_RNaseH PF17917.1 PIK40305.1 - 1.4e-29 102.5 0.0 2.2e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40305.1 - 1.3e-20 73.3 0.1 3.9e-20 71.8 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase NACHT PF05729.12 PIK40306.1 - 1e-18 67.8 0.1 4.2e-18 65.8 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK40306.1 - 0.00045 19.9 0.0 0.0025 17.4 0.0 2.0 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK40306.1 - 0.00069 19.9 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK40306.1 - 0.028 13.7 0.0 0.068 12.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 PIK40306.1 - 0.048 14.1 0.0 0.7 10.3 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.6 PIK40306.1 - 0.049 14.0 0.0 0.29 11.5 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain DUF4283 PF14111.6 PIK40309.1 - 0.08 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) G-patch PF01585.23 PIK40310.1 - 7.6e-13 48.1 3.4 1.7e-12 47.0 3.4 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK40310.1 - 0.032 14.3 0.9 0.081 13.0 0.9 1.7 1 0 0 1 1 1 0 G-patch domain SOG2 PF10428.9 PIK40310.1 - 2.3 7.3 15.2 2.7 7.1 15.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 PIK40310.1 - 3.6 6.3 11.6 4.3 6.1 11.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 PIK40310.1 - 9.8 4.8 8.1 13 4.4 8.1 1.1 1 0 0 1 1 1 0 Presenilin Surp PF01805.20 PIK40312.1 - 9.5e-15 54.3 0.5 9.5e-15 54.3 0.5 2.2 2 1 0 2 2 2 1 Surp module CTD_bind PF04818.13 PIK40312.1 - 2.7e-14 53.7 0.1 2.7e-14 53.7 0.1 3.2 3 1 1 4 4 4 1 RNA polymerase II-binding domain. Rx_N PF18052.1 PIK40312.1 - 0.06 13.6 8.5 0.15 12.3 3.8 3.7 4 1 0 4 4 4 0 Rx N-terminal domain FAM60A PF15396.6 PIK40312.1 - 2.2 8.2 14.6 0.39 10.7 6.9 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Tim29 PF10171.9 PIK40313.1 - 5e-60 201.8 0.1 5.8e-60 201.6 0.1 1.0 1 0 0 1 1 1 1 Translocase of the Inner Mitochondrial membrane 29 LURAP PF14854.6 PIK40314.1 - 7.6e-06 25.9 0.3 2.1e-05 24.5 0.3 1.7 1 0 0 1 1 1 1 Leucine rich adaptor protein PfUIS3 PF11567.8 PIK40314.1 - 0.052 13.9 0.2 0.17 12.3 0.2 1.9 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Pup PF05639.11 PIK40314.1 - 4.8 8.2 8.2 0.64 11.0 0.3 3.5 2 1 0 2 2 2 0 Pup-like protein CD225 PF04505.12 PIK40315.1 - 0.012 15.7 1.7 0.02 15.0 0.1 2.3 2 0 0 2 2 2 0 Interferon-induced transmembrane protein Laminin_EGF PF00053.24 PIK40315.1 - 0.22 11.7 2.9 0.65 10.2 2.9 1.9 1 0 0 1 1 1 0 Laminin EGF domain Acetyltransf_2 PF00797.17 PIK40317.1 - 1.1e-08 35.2 0.0 1.4e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase Tocopherol_cycl PF14249.6 PIK40319.1 - 1.7e-11 43.9 0.1 5.2e-07 29.1 0.0 2.9 3 0 0 3 3 3 2 Tocopherol cyclase Helicase_C_4 PF13871.6 PIK40320.1 - 5.5e-121 403.4 0.0 9.4e-121 402.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Helicase_C PF00271.31 PIK40320.1 - 0.1 12.9 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 Helicase conserved C-terminal domain Cwf_Cwc_15 PF04889.12 PIK40320.1 - 4.8 6.9 25.6 8.3 6.1 25.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AAA_34 PF13872.6 PIK40321.1 - 1.1e-138 461.2 0.0 1.5e-138 460.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 ResIII PF04851.15 PIK40321.1 - 0.00024 21.1 0.0 0.00047 20.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zot PF05707.12 PIK40321.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) Ribosomal_L3 PF00297.22 PIK40322.1 - 0.00075 18.6 0.3 0.00094 18.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Gal_Lectin PF02140.18 PIK40323.1 - 9.9e-22 77.2 3.4 9.9e-22 77.2 3.4 2.5 3 0 0 3 3 3 1 Galactose binding lectin domain GPS PF01825.21 PIK40323.1 - 8.6e-18 64.6 3.3 8.6e-18 64.6 3.3 3.0 4 0 0 4 4 4 1 GPCR proteolysis site, GPS, motif Pyridox_ox_2 PF12900.7 PIK40323.1 - 0.0084 16.1 0.0 0.048 13.7 0.0 2.0 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase DUF5641 PF18701.1 PIK40324.1 - 1.7e-35 121.0 2.1 3.5e-35 120.0 2.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK40324.1 - 1.3e-05 25.4 0.0 3.8e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain PCB_OB PF17092.5 PIK40324.1 - 0.073 13.8 0.1 0.2 12.4 0.1 1.7 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain 7tm_2 PF00002.24 PIK40325.1 - 1.8e-18 66.7 12.4 2.9e-18 66.1 12.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK40325.1 - 9.2e-12 45.3 2.5 1.8e-11 44.4 2.5 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HYR PF02494.16 PIK40326.1 - 2.4e-66 220.0 29.8 3.6e-22 78.5 1.6 5.4 5 0 0 5 5 5 5 HYR domain CDtoxinA PF03498.14 PIK40326.1 - 3e-06 26.9 0.3 1.5 8.4 0.0 3.4 3 0 0 3 3 3 3 Cytolethal distending toxin A/C domain HU-CCDC81_bac_1 PF18174.1 PIK40326.1 - 0.027 14.3 0.0 52 3.8 0.0 3.3 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 1 Prok-RING_4 PF14447.6 PIK40326.1 - 0.086 12.7 2.2 73 3.3 0.1 3.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 SprB PF13573.6 PIK40326.1 - 1.6 8.6 13.9 20 5.1 0.3 5.0 4 0 0 4 4 4 0 SprB repeat SCRL PF06876.12 PIK40326.1 - 4.3 7.6 12.7 27 5.0 0.5 3.4 3 0 0 3 3 3 0 Plant self-incompatibility response (SCRL) protein EGF_CA PF07645.15 PIK40327.1 - 5.6e-48 160.9 89.4 5.7e-10 39.2 10.8 5.1 5 0 0 5 5 5 5 Calcium-binding EGF domain EGF_3 PF12947.7 PIK40327.1 - 8.3e-40 134.7 85.6 1.3e-10 41.3 14.4 6.5 3 2 4 7 7 7 5 EGF domain cEGF PF12662.7 PIK40327.1 - 4.3e-33 112.9 36.8 5.2e-09 35.9 2.2 5.8 5 0 0 5 5 5 5 Complement Clr-like EGF-like EGF PF00008.27 PIK40327.1 - 4.9e-12 45.9 67.5 0.0004 20.6 7.1 7.0 5 3 0 5 5 5 4 EGF-like domain EGF_MSP1_1 PF12946.7 PIK40327.1 - 1.8e-11 43.9 67.5 0.00033 20.6 7.9 5.3 5 0 0 5 5 5 5 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK40327.1 - 2.6e-07 30.8 69.6 0.0082 16.4 9.7 5.9 2 2 3 5 5 5 4 Pvs28 EGF domain hEGF PF12661.7 PIK40327.1 - 0.00022 21.7 27.7 0.0059 17.2 2.4 9.7 9 2 1 10 10 10 5 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK40327.1 - 0.00028 21.1 73.0 2.6 8.4 10.9 5.9 1 1 4 5 5 5 3 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK40327.1 - 0.14 12.6 78.6 0.083 13.3 8.1 6.7 3 2 2 5 5 5 0 EGF-like domain SH3_16 PF18348.1 PIK40327.1 - 0.19 11.6 0.7 28 4.6 0.0 2.6 3 0 0 3 3 3 0 Bacterial dipeptidyl-peptidase Sh3 domain CC2D2AN-C2 PF15625.6 PIK40327.1 - 0.56 9.9 2.3 2 8.1 0.0 2.6 2 1 1 3 3 3 0 CC2D2A N-terminal C2 domain EGF_3 PF12947.7 PIK40328.1 - 1.9e-11 44.0 12.7 1.9e-11 44.0 12.7 2.6 1 1 0 2 2 2 1 EGF domain EGF_CA PF07645.15 PIK40328.1 - 2.3e-10 40.5 12.5 2.3e-10 40.5 12.5 2.6 2 1 0 2 2 2 1 Calcium-binding EGF domain Lectin_C PF00059.21 PIK40328.1 - 2.5e-09 37.8 0.5 8.6e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Lectin C-type domain EGF PF00008.27 PIK40328.1 - 3e-09 37.0 27.5 6.4e-06 26.4 7.2 3.0 3 0 0 3 3 3 2 EGF-like domain EGF_2 PF07974.13 PIK40328.1 - 1e-05 25.8 33.7 4.4e-05 23.8 14.0 3.0 2 1 1 3 3 3 2 EGF-like domain hEGF PF12661.7 PIK40328.1 - 1.1e-05 25.8 16.9 0.00014 22.3 5.1 4.1 4 1 0 4 4 4 2 Human growth factor-like EGF cEGF PF12662.7 PIK40328.1 - 5.9e-05 22.9 3.1 5.9e-05 22.9 3.1 3.6 3 1 0 3 3 3 2 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK40328.1 - 0.00032 20.7 7.0 0.00032 20.7 7.0 2.5 2 0 0 2 2 2 1 MSP1 EGF domain 1 FXa_inhibition PF14670.6 PIK40328.1 - 4.2 7.7 27.4 1.5 9.2 12.4 2.8 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site TNF PF00229.18 PIK40329.1 - 1.1e-11 44.8 0.0 2.5e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family NPP1 PF05630.11 PIK40329.1 - 0.072 13.2 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Necrosis inducing protein (NPP1) MTHFR_C PF12225.8 PIK40329.1 - 0.24 11.0 4.9 0.084 12.5 0.7 2.2 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal fn3 PF00041.21 PIK40330.1 - 2.8e-17 62.8 7.8 2.2e-08 34.3 1.4 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK40330.1 - 0.00057 20.4 9.6 0.06 13.9 0.8 3.1 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF4448 PF14610.6 PIK40330.1 - 0.0051 16.6 0.0 0.013 15.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Interfer-bind PF09294.10 PIK40330.1 - 0.006 16.9 0.1 0.89 9.9 0.0 2.6 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III TMEM154 PF15102.6 PIK40330.1 - 0.0073 16.2 0.3 0.028 14.3 0.0 2.1 2 0 0 2 2 2 1 TMEM154 protein family fn3_2 PF16893.5 PIK40330.1 - 0.016 15.4 0.7 4.1 7.6 0.1 2.8 2 0 0 2 2 2 0 Fibronectin type III domain DUF2207 PF09972.9 PIK40330.1 - 4.8 5.8 8.0 19 3.9 8.0 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Y_phosphatase PF00102.27 PIK40331.1 - 2.5e-37 128.7 0.2 3.4e-37 128.3 0.2 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase NTPase_P4 PF11602.8 PIK40331.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.4 2 0 0 2 2 2 0 ATPase P4 of dsRNA bacteriophage phi-12 RR_TM4-6 PF06459.12 PIK40332.1 - 0.0038 17.1 2.4 0.0049 16.7 2.4 1.0 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 UPF0552 PF10574.9 PIK40332.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Arp2/3-interacting proteins Arpin Vps54 PF07928.12 PIK40334.1 - 1.2e-48 165.0 1.9 2.1e-48 164.1 0.1 2.4 2 0 0 2 2 2 1 Vps54-like protein Vps54_N PF10475.9 PIK40334.1 - 1.2e-12 47.8 1.8 2.5e-12 46.7 1.8 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Sec8_exocyst PF04048.14 PIK40334.1 - 0.0064 16.4 2.6 0.026 14.4 2.6 2.0 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain zf-met PF12874.7 PIK40334.1 - 0.013 15.9 0.2 0.045 14.2 0.2 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK40334.1 - 0.73 10.4 4.2 0.42 11.2 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-RVT PF13966.6 PIK40335.1 - 2.5e-08 34.5 1.9 2.5e-08 34.5 1.9 2.0 2 0 0 2 2 1 1 zinc-binding in reverse transcriptase Sipho_Gp157 PF05565.11 PIK40335.1 - 0.011 15.8 1.4 0.011 15.8 1.4 2.0 2 0 0 2 2 2 0 Siphovirus Gp157 DUF1664 PF07889.12 PIK40335.1 - 0.088 12.8 7.4 0.034 14.2 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TSC22 PF01166.18 PIK40335.1 - 0.19 12.0 7.1 0.12 12.7 0.4 3.7 3 1 1 4 4 4 0 TSC-22/dip/bun family DUF4140 PF13600.6 PIK40335.1 - 0.49 10.9 9.1 0.61 10.6 1.4 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Fzo_mitofusin PF04799.13 PIK40335.1 - 0.57 9.7 6.5 0.15 11.6 2.3 2.1 2 0 0 2 2 2 0 fzo-like conserved region MbeD_MobD PF04899.12 PIK40335.1 - 0.59 10.3 3.4 0.41 10.8 0.6 2.3 2 0 0 2 2 1 0 MbeD/MobD like DivIC PF04977.15 PIK40335.1 - 0.98 9.2 7.3 0.45 10.3 1.8 3.0 2 0 0 2 2 2 0 Septum formation initiator DUF4047 PF13256.6 PIK40335.1 - 1 9.6 4.6 0.35 11.1 1.3 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4047) APC_N_CC PF16689.5 PIK40335.1 - 1.1 9.4 5.3 2 8.5 1.4 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Ax_dynein_light PF10211.9 PIK40335.1 - 2 8.3 15.4 0.55 10.2 2.6 3.1 3 0 0 3 3 3 0 Axonemal dynein light chain Snapin_Pallidin PF14712.6 PIK40335.1 - 4.9 7.6 15.6 0.12 12.8 1.2 4.0 4 0 0 4 4 4 0 Snapin/Pallidin Exonuc_VII_L PF02601.15 PIK40335.1 - 5.8 6.4 13.5 14 5.2 0.1 2.3 2 1 0 2 2 2 0 Exonuclease VII, large subunit HALZ PF02183.18 PIK40335.1 - 7.1 7.0 8.1 2 8.7 0.6 3.5 3 1 1 4 4 4 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.9 PIK40335.1 - 8.8 6.3 20.2 0.34 10.9 7.1 3.0 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OATP PF03137.20 PIK40336.1 - 1.2e-29 103.1 5.0 1.3e-29 102.9 5.0 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK40336.1 - 3e-06 27.3 9.3 5.9e-06 26.3 9.3 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK40336.1 - 0.0011 18.9 8.7 0.0023 17.9 8.7 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain LRR_8 PF13855.6 PIK40337.1 - 1.9e-24 85.1 24.8 3.2e-11 42.8 0.9 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK40337.1 - 9.2e-13 48.2 16.5 0.00042 20.7 0.0 3.5 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK40337.1 - 3.3e-10 40.0 0.1 9.8e-10 38.5 0.0 1.5 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK40337.1 - 8.2e-06 25.4 3.5 0.0017 17.9 0.3 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK40337.1 - 0.00074 19.4 15.7 0.32 11.1 0.0 5.6 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 PIK40337.1 - 0.00082 19.6 16.7 0.046 14.3 0.1 5.1 4 1 0 4 4 4 2 Leucine Rich Repeat Sulfatase PF00884.23 PIK40338.1 - 2e-61 208.1 0.2 3.1e-61 207.5 0.2 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK40338.1 - 0.036 14.8 0.0 0.1 13.3 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 PIK40338.1 - 0.041 13.8 0.0 0.15 11.9 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF3665 PF12427.8 PIK40338.1 - 0.23 11.2 0.4 0.5 10.1 0.4 1.4 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase Peroxin-3 PF04882.12 PIK40339.1 - 8.1e-37 127.3 1.1 1.1e-35 123.6 1.1 1.9 1 1 0 1 1 1 1 Peroxin-3 TA_inhibitor PF17574.2 PIK40340.1 - 0.0007 19.6 0.1 1.4 9.0 0.0 3.4 1 1 2 3 3 3 2 Inhibitor of toxin/antitoxin system (Gp4.5) DUF2102 PF09875.9 PIK40340.1 - 0.0043 16.8 1.0 5.4 6.8 0.1 2.9 1 1 2 3 3 3 3 Uncharacterized protein conserved in archaea (DUF2102) DNAP_B_exo_N PF08452.10 PIK40340.1 - 0.1 12.1 3.5 6.6 6.2 0.3 2.4 2 0 0 2 2 2 0 DNA polymerase family B exonuclease domain, N-terminal NinF PF05810.12 PIK40340.1 - 0.15 12.0 0.1 29 4.6 0.0 2.6 2 0 0 2 2 2 0 NinF protein Integrase_H2C2 PF17921.1 PIK40340.1 - 1.8 8.7 9.4 1.3e+02 2.8 0.1 4.7 2 2 3 5 5 5 0 Integrase zinc binding domain Dickkopf_N PF04706.12 PIK40341.1 - 4.1e-12 46.4 22.0 4.1e-12 46.4 22.0 3.2 2 1 1 3 3 3 2 Dickkopf N-terminal cysteine-rich region Prokineticin PF06607.11 PIK40341.1 - 0.0011 19.3 7.2 0.0011 19.3 7.2 2.5 2 0 0 2 2 2 1 Prokineticin DUF3456 PF11938.8 PIK40342.1 - 2.7e-06 28.0 0.6 0.0018 18.8 0.6 2.5 1 1 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP NAD_binding_8 PF13450.6 PIK40343.1 - 3.1e-14 52.9 0.0 5.5e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 PIK40343.1 - 0.0022 18.0 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 PIK40343.1 - 0.06 13.9 0.0 6.3 7.4 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK40343.1 - 0.18 11.0 0.0 0.51 9.5 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain Sulfotransfer_2 PF03567.14 PIK40344.1 - 5.7e-30 105.1 3.4 1e-27 97.6 3.4 2.4 1 1 0 1 1 1 1 Sulfotransferase family HTH_27 PF13463.6 PIK40344.1 - 0.043 14.3 0.4 0.23 12.0 0.1 2.3 3 0 0 3 3 3 0 Winged helix DNA-binding domain Menin PF05053.13 PIK40345.1 - 0.79 8.0 3.6 0.75 8.1 3.6 1.1 1 0 0 1 1 1 0 Menin NARP1 PF12569.8 PIK40345.1 - 3.9 6.3 8.8 4.6 6.0 8.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Enkurin PF13864.6 PIK40346.1 - 8.1e-10 39.0 0.3 8.1e-10 39.0 0.3 2.7 3 0 0 3 3 3 1 Calmodulin-binding DUF3140 PF11338.8 PIK40346.1 - 1.9 9.0 5.4 1.6 9.2 1.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3140) P4Ha_N PF08336.11 PIK40348.1 - 3.1e-35 121.1 0.9 5.1e-35 120.4 0.9 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_2 PF07719.17 PIK40348.1 - 7.6e-05 22.5 0.5 0.0017 18.3 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK40348.1 - 0.00019 21.5 0.0 0.00051 20.1 0.0 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 PIK40348.1 - 0.0025 17.6 0.6 0.018 14.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK40348.1 - 0.0068 16.6 0.0 0.53 10.5 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK40348.1 - 0.012 15.8 0.1 0.086 13.0 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40348.1 - 0.045 14.6 2.9 1.8 9.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat CNDH2_C PF16858.5 PIK40348.1 - 0.13 12.1 2.2 0.077 12.9 0.4 1.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term TPR_19 PF14559.6 PIK40348.1 - 0.18 12.4 3.5 0.29 11.7 0.1 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Gar1 PF04410.14 PIK40349.1 - 7.7e-36 123.2 0.0 9.3e-36 122.9 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Rap_GAP PF02145.15 PIK40350.1 - 3.2e-58 196.3 0.1 1.6e-50 171.2 0.0 2.4 2 0 0 2 2 2 2 Rap/ran-GAP GoLoco PF02188.17 PIK40350.1 - 4.8e-06 26.0 5.1 4.8e-06 26.0 5.1 2.0 2 0 0 2 2 2 1 GoLoco motif SRPRB PF09439.10 PIK40351.1 - 1.8e-44 151.3 0.4 2e-44 151.2 0.4 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 PIK40351.1 - 1.8e-17 63.3 0.2 2.1e-17 63.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK40351.1 - 1.7e-08 34.6 0.0 2.3e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK40351.1 - 0.00028 20.4 1.0 0.002 17.7 1.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 PIK40351.1 - 0.0018 18.5 0.0 0.0033 17.6 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK40351.1 - 0.0042 16.6 1.1 0.45 10.0 0.1 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain G-alpha PF00503.20 PIK40351.1 - 0.005 16.0 1.2 0.26 10.4 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit ATP_bind_1 PF03029.17 PIK40351.1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein MobB PF03205.14 PIK40351.1 - 0.018 14.9 0.1 0.034 14.1 0.1 1.5 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 PIK40351.1 - 0.052 13.2 0.2 7.5 6.1 0.0 2.2 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 PIK40351.1 - 0.053 13.9 0.1 0.066 13.6 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain DUF2855 PF11017.8 PIK40351.1 - 0.073 12.8 0.0 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) RsgA_GTPase PF03193.16 PIK40351.1 - 0.12 12.2 0.3 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Mito_carr PF00153.27 PIK40352.1 - 3.5e-33 113.4 1.3 4.5e-16 58.5 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein LicD PF04991.13 PIK40353.1 - 0.084 13.0 4.9 0.098 12.8 4.9 1.1 1 0 0 1 1 1 0 LicD family Tim54 PF11711.8 PIK40353.1 - 0.23 10.2 14.7 0.025 13.4 10.2 1.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SRP-alpha_N PF04086.13 PIK40353.1 - 0.59 10.0 21.5 0.85 9.5 21.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal GRP PF07172.11 PIK40353.1 - 0.74 10.5 0.0 0.74 10.5 0.0 2.9 2 1 0 2 2 2 0 Glycine rich protein family Bud13 PF09736.9 PIK40353.1 - 0.75 10.2 19.0 0.61 10.5 15.2 2.0 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex FGF-BP1 PF06473.12 PIK40353.1 - 1.5 8.6 16.4 13 5.5 12.7 2.2 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) SLC12 PF03522.15 PIK40353.1 - 3.2 6.7 9.3 4 6.3 9.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 UPF0688 PF15772.5 PIK40353.1 - 3.5 7.8 16.1 0.55 10.4 12.2 1.6 2 0 0 2 2 2 0 UPF0688 family SAPS PF04499.15 PIK40353.1 - 5.5 5.7 8.0 6.8 5.3 8.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Rxt3 PF08642.10 PIK40353.1 - 8.9 7.1 9.8 16 6.3 6.5 2.5 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 Draxin PF15550.6 PIK40354.1 - 8.9e-06 25.8 13.8 1e-05 25.6 13.8 1.0 1 0 0 1 1 1 1 Draxin Dickkopf_N PF04706.12 PIK40354.1 - 0.0074 16.8 19.0 0.017 15.6 19.0 1.6 1 0 0 1 1 1 1 Dickkopf N-terminal cysteine-rich region Metallothio_6 PF05522.11 PIK40354.1 - 0.032 14.7 18.1 0.05 14.1 18.1 1.3 1 0 0 1 1 1 0 Metallothionein DX PF01666.17 PIK40354.1 - 0.035 14.6 8.3 0.035 14.6 8.3 2.3 1 1 1 2 2 2 0 DX module AGTRAP PF06396.11 PIK40356.1 - 1.6e-26 92.9 0.0 2.1e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) DUF4199 PF13858.6 PIK40356.1 - 4 7.8 6.8 15 6.0 6.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) LRR_4 PF12799.7 PIK40357.1 - 3.1e-29 100.5 23.1 8.2e-08 32.4 1.0 5.6 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK40357.1 - 6.2e-19 68.1 7.0 6.8e-16 58.3 1.8 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 PIK40357.1 - 5.3e-17 61.3 36.7 3.4e-09 36.3 2.0 4.9 1 1 6 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 PIK40357.1 - 2.3e-13 49.0 25.8 0.03 14.3 0.1 7.7 7 1 1 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.33 PIK40357.1 - 0.00068 19.8 19.8 3 8.7 0.2 7.5 6 2 0 6 6 6 1 Leucine Rich Repeat LRR_3 PF07725.12 PIK40357.1 - 0.027 14.3 2.2 0.47 10.4 0.1 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat zf-C2H2 PF00096.26 PIK40358.1 - 0.15 12.5 54.3 0.037 14.5 2.0 7.3 6 1 0 6 6 6 0 Zinc finger, C2H2 type OrsD PF12013.8 PIK40359.1 - 0.11 12.9 0.3 0.11 12.9 0.3 2.8 2 1 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D Coatomer_WDAD PF04053.14 PIK40361.1 - 1.1e-168 561.9 1.0 8.8e-156 519.4 0.1 2.8 2 1 1 3 3 3 2 Coatomer WD associated region WD40 PF00400.32 PIK40361.1 - 6.1e-36 121.8 11.9 9.4e-08 32.6 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40361.1 - 2.4e-06 27.7 0.8 2 8.8 0.0 5.7 2 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 PIK40362.1 - 0.023 14.5 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK40363.1 - 2.1e-20 72.3 1.0 1.6e-15 56.6 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK40363.1 - 0.017 15.2 0.3 1.1 9.4 0.0 2.7 2 1 1 3 3 3 0 RNA binding motif Limkain-b1 PF11608.8 PIK40363.1 - 0.028 14.5 0.2 0.46 10.6 0.0 2.6 2 1 1 3 3 3 0 Limkain b1 Nup35_RRM_2 PF14605.6 PIK40363.1 - 0.058 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 PIK40363.1 - 0.11 12.6 0.0 0.32 11.1 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif SPOC PF07744.13 PIK40364.1 - 9.1e-30 103.6 0.0 2.8e-29 102.0 0.0 1.8 1 0 0 1 1 1 1 SPOC domain DUF2880 PF11082.8 PIK40364.1 - 0.43 10.9 3.4 1.9 8.9 3.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) cobW PF02492.19 PIK40365.1 - 3.3e-15 56.1 0.0 5.4e-15 55.4 0.0 1.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain TIP49 PF06068.13 PIK40365.1 - 0.026 13.7 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain ABC_tran PF00005.27 PIK40365.1 - 0.03 14.8 0.0 0.037 14.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 PIK40365.1 - 0.031 14.7 0.0 0.038 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 PIK40365.1 - 0.057 13.6 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK40365.1 - 0.061 13.7 0.0 2.7 8.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 PIK40365.1 - 0.089 13.3 0.0 0.19 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain Hist_deacetyl PF00850.19 PIK40365.1 - 0.098 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Histone deacetylase domain Mito_fiss_Elm1 PF06258.11 PIK40365.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 MMR_HSR1 PF01926.23 PIK40365.1 - 0.18 11.9 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase CENP-H PF05837.12 PIK40366.1 - 0.007 16.8 4.5 0.007 16.8 4.5 6.1 3 1 3 6 6 6 1 Centromere protein H (CENP-H) Sec3_C_2 PF15278.6 PIK40366.1 - 0.86 10.0 6.4 0.43 10.9 1.7 2.8 2 0 0 2 2 2 0 Sec3 exocyst complex subunit CUB PF00431.20 PIK40367.1 - 2.8e-15 56.6 0.0 0.00055 20.2 0.0 3.3 3 0 0 3 3 3 3 CUB domain EGF_2 PF07974.13 PIK40367.1 - 0.0015 18.9 11.4 0.0015 18.9 11.4 2.6 2 0 0 2 2 2 1 EGF-like domain EGF_Tenascin PF18720.1 PIK40367.1 - 0.35 11.0 7.8 0.88 9.7 7.8 1.8 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 PIK40367.1 - 0.48 11.1 16.6 0.09 13.4 7.1 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF IMS PF00817.20 PIK40369.1 - 3.2e-30 105.1 0.1 3.4e-30 105.0 0.1 1.1 1 0 0 1 1 1 1 impB/mucB/samB family DUF4887 PF16228.5 PIK40371.1 - 0.016 15.4 28.1 0.92 9.7 0.5 5.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4887) YL1_C PF08265.11 PIK40371.1 - 0.017 14.9 2.7 1.1e+02 2.7 0.0 5.6 5 0 0 5 5 5 0 YL1 nuclear protein C-terminal domain DUF4754 PF15946.5 PIK40371.1 - 0.02 15.1 9.1 96 3.4 0.1 5.9 6 0 0 6 6 6 0 Domain of unknown function (DUF4754) KfrA_N PF11740.8 PIK40371.1 - 0.54 11.0 7.6 98 3.7 0.1 4.6 5 0 0 5 5 5 0 Plasmid replication region DNA-binding N-term DUF1117 PF06547.12 PIK40371.1 - 1.8 9.1 17.0 35 5.0 0.3 5.8 1 1 5 6 6 6 0 Protein of unknown function (DUF1117) UBM PF14377.6 PIK40372.1 - 7.8e-09 34.7 0.4 0.00012 21.4 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin binding region REV1_C PF16727.5 PIK40373.1 - 0.074 13.5 0.0 0.074 13.5 0.0 1.1 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain Exo_endo_phos_2 PF14529.6 PIK40374.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40375.1 - 8.5e-23 80.3 0.0 1.1e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40375.1 - 4.6e-11 42.9 0.0 6.4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40376.1 - 1.7e-10 40.8 0.0 3.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK40376.1 - 0.029 14.5 0.0 0.1 12.7 0.0 1.9 2 0 0 2 2 2 0 Spumavirus aspartic protease (A9) LRR_8 PF13855.6 PIK40377.1 - 6.4e-14 51.5 6.5 1.1e-07 31.4 0.1 3.7 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK40377.1 - 1.4e-07 31.7 8.6 0.002 18.5 0.2 3.9 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK40377.1 - 0.00039 20.4 2.5 0.00089 19.2 2.5 1.6 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK40377.1 - 0.0024 17.4 0.4 0.011 15.2 0.1 2.1 1 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 PIK40377.1 - 0.12 13.0 8.1 55 4.9 1.2 4.9 4 1 0 4 4 4 0 Leucine Rich Repeat Arf PF00025.21 PIK40378.1 - 2.5e-61 206.1 0.0 3.1e-61 205.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK40378.1 - 4.3e-11 43.1 0.1 5.4e-11 42.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK40378.1 - 4.2e-10 39.3 0.3 8.5e-10 38.3 0.3 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 PIK40378.1 - 4.6e-10 39.3 0.0 5.1e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 PIK40378.1 - 1.3e-06 28.0 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK40378.1 - 6.6e-06 25.6 0.0 7.7e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK40378.1 - 0.024 14.7 0.1 0.043 13.9 0.0 1.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase SpoOE-like PF09388.10 PIK40378.1 - 0.048 13.6 1.1 0.084 12.8 1.1 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein CRISPR_Cas2 PF09827.9 PIK40378.1 - 0.083 13.1 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas2 LRR_8 PF13855.6 PIK40379.1 - 5.2e-54 179.9 55.0 3.4e-10 39.5 1.8 9.2 2 1 5 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 PIK40379.1 - 4.2e-42 141.4 60.6 4.5e-06 26.9 0.9 11.6 6 2 8 14 14 14 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK40379.1 - 6.9e-09 35.4 33.1 0.0024 17.4 1.8 6.3 1 1 6 7 7 7 6 Leucine-rich repeat LRR_1 PF00560.33 PIK40379.1 - 0.0015 18.8 53.1 34 5.5 0.0 15.9 17 3 1 18 18 18 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK40379.1 - 2.9 8.2 58.7 4.4 7.6 1.0 14.6 17 0 0 17 17 17 0 Leucine Rich repeat ING PF12998.7 PIK40379.1 - 4.9 7.8 9.3 1.4 9.6 0.5 4.1 4 1 1 5 5 5 0 Inhibitor of growth proteins N-terminal histone-binding RRM_1 PF00076.22 PIK40380.1 - 3.9e-14 52.2 0.1 4.9e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK40380.1 - 2.6e-05 24.0 0.0 3.2e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 PIK40380.1 - 0.0003 20.4 0.0 0.00033 20.2 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L32e PF01655.18 PIK40381.1 - 8.8e-47 158.0 4.0 1.1e-46 157.7 4.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 AAA PF00004.29 PIK40382.1 - 2.7e-41 141.1 0.1 7.5e-41 139.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK40382.1 - 3e-08 33.3 0.4 9.7e-08 31.7 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 PIK40382.1 - 3.1e-08 33.4 0.0 7.6e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 PIK40382.1 - 3.5e-06 27.5 0.6 0.00051 20.5 0.1 2.7 1 1 2 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 PIK40382.1 - 1e-05 25.5 1.2 8.1e-05 22.6 0.1 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 PIK40382.1 - 9.6e-05 22.2 0.1 0.00023 20.9 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK40382.1 - 0.00014 22.1 0.5 0.024 14.9 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK40382.1 - 0.00027 21.1 0.4 0.0018 18.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 PIK40382.1 - 0.00067 18.9 0.0 0.0012 18.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) JIP_LZII PF16471.5 PIK40382.1 - 0.0026 17.9 4.7 0.0071 16.5 4.7 1.8 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II PhoH PF02562.16 PIK40382.1 - 0.0037 16.8 0.1 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 PIK40382.1 - 0.0096 15.3 0.1 0.024 14.0 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 PIK40382.1 - 0.0097 15.7 0.4 0.79 9.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK40382.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 PIK40382.1 - 0.017 15.3 0.1 0.055 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 PIK40382.1 - 0.017 14.4 0.4 0.092 12.1 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.6 PIK40382.1 - 0.025 14.3 0.2 0.088 12.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain DUF3713 PF12506.8 PIK40382.1 - 0.035 14.4 0.3 0.91 9.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) AAA_18 PF13238.6 PIK40382.1 - 0.053 14.1 0.0 0.16 12.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 PIK40382.1 - 0.055 13.2 0.0 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 PIK40382.1 - 0.055 13.0 0.0 0.13 11.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 PIK40382.1 - 0.079 12.5 0.6 0.33 10.5 0.2 2.0 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK40382.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 PIK40382.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 PIK40382.1 - 0.17 12.2 0.5 0.59 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain PHD PF00628.29 PIK40383.1 - 1.8e-09 37.3 9.9 3e-09 36.6 9.9 1.4 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 PIK40383.1 - 0.0022 17.8 3.3 0.0022 17.8 3.3 2.2 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 PIK40383.1 - 0.0033 17.5 6.4 0.0085 16.2 6.4 1.8 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.6 PIK40383.1 - 0.006 16.7 3.7 0.012 15.8 3.7 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-PHD-like PF15446.6 PIK40383.1 - 0.0066 16.1 6.1 0.0066 16.1 6.1 2.1 2 1 0 2 2 2 1 PHD/FYVE-zinc-finger like domain zinc_ribbon_15 PF17032.5 PIK40383.1 - 0.071 13.9 2.9 0.18 12.6 2.9 1.6 1 0 0 1 1 1 0 zinc-ribbon family Prok-RING_1 PF14446.6 PIK40383.1 - 0.67 9.9 6.9 0.21 11.6 3.0 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_9 PF13901.6 PIK40383.1 - 2 8.3 11.5 0.094 12.7 5.5 1.8 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.6 PIK40383.1 - 3.2 7.4 10.7 0.059 12.9 3.9 1.7 2 0 0 2 2 2 0 PHD-finger Pkinase_Tyr PF07714.17 PIK40384.1 - 6.9e-27 94.4 0.0 9e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40384.1 - 2.3e-12 46.9 0.0 3e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK40385.1 - 8e-07 29.6 2.4 0.00034 21.2 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK40385.1 - 7e-05 22.8 0.4 0.068 13.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK40385.1 - 0.00034 20.9 4.3 0.0011 19.2 0.9 2.5 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK40385.1 - 0.00098 19.3 3.0 0.05 13.8 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK40385.1 - 0.0012 19.2 1.4 0.012 15.9 0.2 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK40385.1 - 0.0082 16.2 0.1 0.03 14.4 0.1 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK40385.1 - 0.058 13.5 0.1 0.17 11.9 0.1 1.9 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain RVT_1 PF00078.27 PIK40386.1 - 2.9e-15 56.4 0.0 3.5e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Acyl_transf_3 PF01757.22 PIK40387.1 - 6.5e-10 38.6 5.9 6.5e-10 38.6 5.9 1.5 2 0 0 2 2 2 1 Acyltransferase family DUF4113 PF13438.6 PIK40389.1 - 0.0089 16.1 0.1 2.4 8.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4113) DUF4113 PF13438.6 PIK40390.1 - 0.00034 20.6 5.1 22 5.3 0.0 4.8 5 0 0 5 5 5 4 Domain of unknown function (DUF4113) DUF3564 PF12087.8 PIK40390.1 - 0.12 12.4 0.4 20 5.1 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3564) Peptidase_C65 PF10275.9 PIK40390.1 - 2.6 7.4 4.8 72 2.7 0.5 3.4 2 2 2 4 4 4 0 Peptidase C65 Otubain DUF4834 PF16118.5 PIK40391.1 - 0.006 17.5 0.0 0.018 16.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Ninjurin PF04923.12 PIK40391.1 - 0.037 14.0 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 Ninjurin TMEM154 PF15102.6 PIK40392.1 - 0.0051 16.7 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 PIK40392.1 - 0.0071 16.6 0.1 0.014 15.7 0.1 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator SAG PF04092.13 PIK40392.1 - 0.065 14.0 0.1 0.11 13.3 0.1 1.5 1 0 0 1 1 1 0 SRS domain DUF4234 PF14018.6 PIK40392.1 - 0.21 11.7 3.6 0.47 10.6 3.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Got1 PF04178.12 PIK40393.1 - 7.3e-38 129.5 16.4 1.1e-37 128.9 16.4 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family DNA_pol_A_exo1 PF01612.20 PIK40394.1 - 1.6e-29 102.9 0.0 3e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 PIK40394.1 - 1.1e-14 54.8 0.0 3.1e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 PIK40394.1 - 1.9e-11 43.8 0.0 5.3e-11 42.3 0.0 1.8 1 0 0 1 1 1 1 HRDC domain DcpS_C PF11969.8 PIK40394.1 - 0.11 12.9 0.2 0.32 11.5 0.2 1.7 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding COMP PF11598.8 PIK40395.1 - 0.87 10.1 5.8 4 8.0 0.4 3.0 2 1 0 2 2 2 0 Cartilage oligomeric matrix protein RT_RNaseH_2 PF17919.1 PIK40396.1 - 1.9e-29 101.6 0.0 4.1e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40396.1 - 7.2e-29 100.9 0.0 1.4e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK40396.1 - 2.2e-27 95.4 0.0 4.6e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK40396.1 - 6.3e-20 71.6 0.0 1.5e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40396.1 - 5.6e-17 61.6 0.7 5.6e-17 61.6 0.7 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK40396.1 - 0.0042 16.8 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK40396.1 - 0.0053 16.9 0.2 0.0053 16.9 0.2 2.2 3 0 0 3 3 3 1 H2C2 zinc finger RVT_thumb PF06817.14 PIK40396.1 - 0.052 13.4 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase thumb domain RVT_1 PF00078.27 PIK40397.1 - 2.7e-08 33.6 0.0 5.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 PIK40397.1 - 0.065 13.6 0.3 0.22 11.9 0.1 2.0 2 0 0 2 2 2 0 PRANC domain Bac_DnaA PF00308.18 PIK40397.1 - 0.094 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein zf-BED PF02892.15 PIK40398.1 - 1.5 8.9 7.2 1.3 9.2 1.7 2.6 2 0 0 2 2 2 0 BED zinc finger zf-DBF PF07535.12 PIK40398.1 - 4 7.6 6.6 17 5.6 0.7 2.8 2 1 0 2 2 2 0 DBF zinc finger SMI1_KNR4 PF09346.10 PIK40399.1 - 1.5e-06 28.7 0.0 1.5e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) DUF525 PF04379.14 PIK40400.1 - 2e-07 31.1 0.0 3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 ApaG domain Linker_histone PF00538.19 PIK40401.1 - 1.2e-21 76.9 0.4 2.1e-21 76.0 0.4 1.4 1 0 0 1 1 1 1 linker histone H1 and H5 family ATP-grasp_3 PF02655.14 PIK40401.1 - 0.061 13.4 0.7 1.5 8.8 0.2 2.0 1 1 1 2 2 2 0 ATP-grasp domain SMI1_KNR4 PF09346.10 PIK40402.1 - 3.8e-06 27.3 0.0 5.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) DUF5080 PF16883.5 PIK40402.1 - 0.15 12.1 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) DUF525 PF04379.14 PIK40403.1 - 1.5e-22 79.6 0.1 2.5e-22 78.9 0.1 1.3 1 0 0 1 1 1 1 ApaG domain DUF749 PF05370.11 PIK40403.1 - 0.085 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF749) THAP PF05485.12 PIK40404.1 - 0.00024 22.0 1.1 0.00064 20.6 1.1 1.8 1 1 0 1 1 1 1 THAP domain SARAF PF06682.12 PIK40404.1 - 0.068 12.8 0.3 0.14 11.8 0.1 1.5 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Milton PF12448.8 PIK40406.1 - 0.03 14.4 0.1 0.046 13.8 0.1 1.3 1 0 0 1 1 1 0 Kinesin associated protein RVT_1 PF00078.27 PIK40407.1 - 1.8e-17 63.6 0.0 2.3e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK40408.1 - 8.4e-11 41.8 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK40409.1 - 0.00044 20.2 3.2 0.0013 18.8 3.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK40409.1 - 0.041 13.6 0.5 0.11 12.3 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 PIK40410.1 - 1.4e-09 37.8 0.0 2.1e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MATalpha_HMGbox PF04769.12 PIK40410.1 - 0.17 11.2 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SCAN PF02023.17 PIK40411.1 - 3.4e-16 58.8 0.1 7.1e-16 57.8 0.1 1.6 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK40411.1 - 0.081 13.2 0.0 3.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Retrotransposon gag protein I-set PF07679.16 PIK40412.1 - 1.8e-62 207.4 0.0 8.7e-16 57.8 0.0 4.7 5 0 0 5 5 4 4 Immunoglobulin I-set domain Pkinase PF00069.25 PIK40412.1 - 4.9e-59 199.9 0.0 6.4e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK40412.1 - 4.8e-39 132.8 0.0 8e-11 42.4 0.0 4.7 5 0 0 5 5 5 4 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK40412.1 - 1.8e-28 99.5 0.0 2.5e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ig PF00047.25 PIK40412.1 - 6.5e-25 87.1 0.0 7.9e-07 29.2 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK40412.1 - 2e-20 72.9 0.0 4e-05 23.9 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK40412.1 - 1.7e-15 57.1 0.0 0.0035 17.5 0.0 5.4 4 1 0 4 4 4 4 Immunoglobulin V-set domain fn3 PF00041.21 PIK40412.1 - 1.5e-08 34.9 0.0 3.7e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Kdo PF06293.14 PIK40412.1 - 0.00047 19.6 0.0 0.00079 18.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pur_ac_phosph_N PF16656.5 PIK40412.1 - 0.00056 20.4 0.0 0.0016 19.0 0.0 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 PIK40412.1 - 0.00097 19.2 0.0 1 9.5 0.0 3.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.11 PIK40412.1 - 0.0033 17.4 0.0 0.072 13.1 0.0 2.9 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Kinase-like PF14531.6 PIK40412.1 - 0.0036 16.7 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 PIK40412.1 - 0.0065 16.4 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Interfer-bind PF09294.10 PIK40412.1 - 0.0081 16.5 0.0 0.032 14.5 0.0 1.9 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Ig_C17orf99 PF17736.1 PIK40412.1 - 0.073 13.1 0.1 5.6 7.1 0.0 3.4 4 0 0 4 4 4 0 C17orf99 Ig domain Ig_6 PF18452.1 PIK40412.1 - 0.096 12.3 0.1 3.7 7.2 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin domain I-set PF07679.16 PIK40413.1 - 3.7e-20 71.8 0.1 4.8e-20 71.4 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40413.1 - 1.1e-14 54.8 0.0 1.8e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40413.1 - 1.4e-12 47.8 0.2 1.8e-12 47.4 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK40413.1 - 2.1e-10 40.6 0.2 3.2e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK40413.1 - 4.4e-08 33.3 0.4 0.00059 20.0 0.1 2.3 1 1 1 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK40413.1 - 0.00047 19.7 0.0 0.00077 19.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Receptor_2B4 PF11465.8 PIK40413.1 - 0.0067 16.6 0.0 0.0081 16.4 0.0 1.2 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 Adeno_E3_CR1 PF02440.15 PIK40413.1 - 0.01 15.6 0.2 0.015 15.1 0.2 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.5 PIK40413.1 - 0.02 15.0 0.0 0.035 14.1 0.0 1.6 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain Pkinase PF00069.25 PIK40414.1 - 3.2e-08 33.3 0.0 4.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PACT_coil_coil PF10495.9 PIK40414.1 - 0.076 13.6 2.2 0.14 12.8 2.2 1.5 1 1 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein EamA PF00892.20 PIK40415.1 - 7e-05 23.0 27.4 0.00011 22.4 2.9 3.4 3 1 0 3 3 3 3 EamA-like transporter family OapA_N PF08525.11 PIK40415.1 - 0.11 12.4 2.9 0.44 10.5 2.9 2.1 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Cupin_8 PF13621.6 PIK40416.1 - 2.7e-20 73.2 3.2 5.6e-20 72.1 3.2 1.5 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 PIK40416.1 - 8.6e-20 71.3 1.3 2.8e-19 69.6 1.3 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase Laminin_G_3 PF13385.6 PIK40417.1 - 4.4e-09 36.7 0.5 7.5e-09 35.9 0.5 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 PIK40418.1 - 1.9e-32 112.6 5.6 4.2e-31 108.2 5.6 2.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4704) IBN_N PF03810.19 PIK40418.1 - 0.086 12.8 0.0 0.26 11.2 0.0 1.9 1 0 0 1 1 1 0 Importin-beta N-terminal domain SRC-1 PF08832.10 PIK40419.1 - 3.3 8.8 6.6 1.2 10.2 1.9 2.4 1 1 1 2 2 2 0 Steroid receptor coactivator Keratin_2_head PF16208.5 PIK40420.1 - 2 8.5 20.6 4.2 7.5 20.6 1.5 1 0 0 1 1 1 0 Keratin type II head RVT_1 PF00078.27 PIK40421.1 - 2.8e-43 148.0 0.1 3.4e-43 147.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_4 PF14392.6 PIK40422.1 - 0.00057 19.6 7.2 0.16 11.7 0.4 2.7 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 PIK40422.1 - 0.0019 18.2 3.3 0.0019 18.2 3.3 2.5 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK40424.1 - 0.0011 19.5 0.0 0.0082 16.7 0.0 2.5 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK40424.1 - 0.0047 17.5 0.0 0.014 16.0 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK40424.1 - 0.016 15.5 0.0 0.095 13.0 0.0 2.2 1 1 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 PIK40425.1 - 2.2e-10 40.4 0.1 3.5e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK40425.1 - 0.00017 21.6 0.0 0.00039 20.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK40426.1 - 1.5e-19 70.4 0.0 2.7e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK40426.1 - 0.00017 21.3 0.1 0.00068 19.4 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain DUF4288 PF14119.6 PIK40426.1 - 0.093 13.1 0.2 0.18 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) LZ_Tnp_IS66 PF13007.7 PIK40426.1 - 0.46 11.3 1.9 12 6.8 0.2 2.4 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain BEN PF10523.9 PIK40429.1 - 0.025 14.8 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 BEN domain HTH_12 PF08461.10 PIK40430.1 - 0.011 15.7 0.8 0.068 13.1 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain HTH_21 PF13276.6 PIK40430.1 - 0.024 14.8 1.0 3.5 7.8 0.1 2.6 2 0 0 2 2 2 0 HTH-like domain DUF1456 PF07308.13 PIK40430.1 - 0.064 13.6 0.2 0.63 10.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) RVT_1 PF00078.27 PIK40432.1 - 1.6e-29 103.0 0.0 2.2e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IFT46_B_C PF12317.8 PIK40433.1 - 7.1e-103 342.9 1.0 8.3e-103 342.6 1.0 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal CENP-B_dimeris PF09026.10 PIK40433.1 - 4.9 7.6 11.0 11 6.5 11.0 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3245 PF11595.8 PIK40434.1 - 5.6 7.4 10.5 4.9 7.6 7.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3245) DUF3246 PF11596.8 PIK40434.1 - 6.8 6.1 8.8 25 4.2 8.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) PBP1_TM PF14812.6 PIK40434.1 - 8.9 6.8 16.5 2.2 8.7 5.5 2.6 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR_9 PF14580.6 PIK40435.1 - 4.8e-19 68.5 1.1 5.1e-07 29.4 0.0 4.2 3 1 1 4 4 4 3 Leucine-rich repeat LRR_4 PF12799.7 PIK40435.1 - 8e-14 51.5 21.4 0.036 14.5 0.7 8.9 4 2 6 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK40435.1 - 4.8e-07 29.4 13.7 0.22 11.3 0.2 7.2 4 2 4 8 8 8 4 Leucine rich repeat LRR_6 PF13516.6 PIK40435.1 - 0.0021 17.9 0.2 34 4.8 0.1 5.5 6 0 0 6 6 6 1 Leucine Rich repeat SMC_ScpA PF02616.14 PIK40435.1 - 1.1 9.1 4.3 2.6 7.9 0.3 2.3 2 0 0 2 2 2 0 Segregation and condensation protein ScpA LRR_9 PF14580.6 PIK40436.1 - 1.8e-09 37.3 0.4 4.8e-05 22.9 0.0 2.8 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 PIK40436.1 - 6.3e-07 29.6 7.4 0.02 15.3 0.4 5.7 3 1 4 7 7 7 3 Leucine Rich repeats (2 copies) Ubiquitin_2 PF14560.6 PIK40436.1 - 0.00049 20.5 1.5 0.0014 19.0 0.6 2.3 3 0 0 3 3 3 1 Ubiquitin-like domain LRR_8 PF13855.6 PIK40436.1 - 0.0018 18.0 4.7 5.3 6.9 1.5 4.9 3 2 2 5 5 5 1 Leucine rich repeat DUF4940 PF16298.5 PIK40436.1 - 0.0079 15.9 0.6 0.9 9.2 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4940) ubiquitin PF00240.23 PIK40436.1 - 0.012 15.4 0.5 0.07 12.9 0.5 2.2 1 1 0 1 1 1 0 Ubiquitin family LRR_6 PF13516.6 PIK40436.1 - 0.014 15.4 0.2 29 5.0 0.1 4.0 3 0 0 3 3 3 0 Leucine Rich repeat Atg14 PF10186.9 PIK40436.1 - 0.032 13.3 1.0 0.055 12.6 1.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RHH_3 PF12651.7 PIK40436.1 - 0.048 13.6 0.3 0.2 11.6 0.3 2.1 1 0 0 1 1 1 0 Ribbon-helix-helix domain LRR_9 PF14580.6 PIK40437.1 - 2.2e-08 33.8 0.4 8.2e-08 31.9 0.0 1.9 1 1 1 3 3 3 1 Leucine-rich repeat LRR_4 PF12799.7 PIK40437.1 - 2e-05 24.9 16.6 0.011 16.1 0.1 4.7 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK40437.1 - 0.00018 21.2 8.0 0.052 13.3 0.2 4.3 2 1 2 4 4 4 3 Leucine rich repeat RT_RNaseH_2 PF17919.1 PIK40438.1 - 2.8e-09 36.9 0.0 7.9e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF1509 PF07420.11 PIK40438.1 - 0.064 12.2 0.1 0.094 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) LRR_9 PF14580.6 PIK40439.1 - 1.5e-16 60.4 1.2 1.6e-07 31.0 0.0 3.4 2 1 2 4 4 4 2 Leucine-rich repeat LRR_4 PF12799.7 PIK40439.1 - 2.1e-09 37.5 26.7 0.019 15.4 0.3 6.9 4 2 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK40439.1 - 2.7e-07 30.3 14.8 0.031 14.0 0.7 5.7 3 2 1 4 4 4 4 Leucine rich repeat Ubiquitin_2 PF14560.6 PIK40439.1 - 4.2e-07 30.3 1.5 7e-07 29.6 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 PIK40439.1 - 0.00025 20.7 0.2 0.0013 18.4 0.2 2.1 1 1 0 1 1 1 1 Ubiquitin family SMC_ScpA PF02616.14 PIK40439.1 - 0.068 13.1 6.3 0.83 9.5 0.3 2.3 2 0 0 2 2 2 0 Segregation and condensation protein ScpA CZB PF13682.6 PIK40439.1 - 0.17 12.3 0.4 1.4 9.4 0.1 2.8 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain IFT46_B_C PF12317.8 PIK40440.1 - 2.3e-15 56.9 0.0 3.2e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal TIR_3 PF18567.1 PIK40440.1 - 0.00092 19.2 0.3 0.0014 18.6 0.3 1.2 1 0 0 1 1 1 1 Toll/interleukin-1 receptor domain EamA PF00892.20 PIK40441.1 - 2.4e-24 86.1 40.4 5.7e-17 62.2 12.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF4199 PF13858.6 PIK40441.1 - 0.0094 16.4 5.6 0.0094 16.4 5.6 3.7 3 2 1 4 4 4 1 Protein of unknown function (DUF4199) DUF4690 PF15756.5 PIK40441.1 - 6.2 7.5 5.3 2.5 8.8 1.6 2.2 2 0 0 2 2 2 0 Small Novel Rich in Cartilage EamA PF00892.20 PIK40442.1 - 4.6e-23 81.9 43.8 2.8e-15 56.7 13.8 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK40442.1 - 0.0042 16.5 2.9 0.0042 16.5 2.9 2.3 2 0 0 2 2 2 1 Triose-phosphate Transporter family E1-E2_ATPase PF00122.20 PIK40443.1 - 1.1e-40 139.1 1.0 1.8e-39 135.1 0.0 2.6 2 1 1 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 PIK40443.1 - 3.4e-25 87.9 0.2 7.1e-25 86.9 0.2 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 PIK40443.1 - 1.1e-16 60.3 0.0 2e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus ER_lumen_recept PF00810.18 PIK40443.1 - 0.044 14.6 1.5 0.065 14.1 0.1 1.9 2 0 0 2 2 2 0 ER lumen protein retaining receptor Hydrolase PF00702.26 PIK40443.1 - 0.076 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4149 PF13664.6 PIK40443.1 - 0.11 12.8 0.8 0.22 11.8 0.0 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) MgtE PF01769.16 PIK40443.1 - 1.3 9.4 8.5 12 6.3 4.6 2.3 2 0 0 2 2 2 0 Divalent cation transporter Exo_endo_phos_2 PF14529.6 PIK40444.1 - 0.0011 18.8 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Death PF00531.22 PIK40445.1 - 1.7e-05 24.9 0.1 4.6e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 Death domain LCE6A PF15858.5 PIK40445.1 - 2.5 8.9 13.7 1.5 9.6 0.9 3.5 3 0 0 3 3 3 0 Late cornified envelope protein 6A family RVT_1 PF00078.27 PIK40447.1 - 0.054 13.0 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Rotavirus_VP7 PF05868.11 PIK40448.1 - 0.025 14.0 0.2 0.038 13.4 0.2 1.3 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 DMSP_lyase PF16867.5 PIK40448.1 - 0.078 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Trypsin PF00089.26 PIK40449.1 - 9e-19 68.2 0.0 1e-18 68.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin VWA PF00092.28 PIK40450.1 - 6.1e-18 65.7 0.0 8.3e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK40450.1 - 2.8e-09 37.6 0.0 3.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Trypsin PF00089.26 PIK40451.1 - 1.5e-50 172.0 0.0 1.7e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK40451.1 - 9.5e-09 35.7 0.0 1.6e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK40451.1 - 8.8e-05 23.4 0.0 0.00023 22.1 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Dimer_Tnp_hAT PF05699.14 PIK40452.1 - 2.1e-09 37.0 0.3 3.9e-09 36.2 0.3 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Gal-3-0_sulfotr PF06990.11 PIK40453.1 - 1.1e-40 139.8 0.7 1.3e-40 139.6 0.7 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK40453.1 - 0.09 13.1 0.2 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 Sulfotransferase family KDZ PF18758.1 PIK40454.1 - 9.9e-45 152.9 0.1 2e-44 151.9 0.1 1.4 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK40454.1 - 1.1e-11 44.9 0.0 3.9e-11 43.0 0.0 1.9 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC1 PF18802.1 PIK40454.1 - 4.8e-06 26.7 0.2 2.3e-05 24.5 0.2 2.2 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK40454.1 - 6.1e-05 22.8 0.8 0.00042 20.1 0.1 2.7 2 0 0 2 2 2 1 CxC3 like cysteine cluster associated with KDZ transposases Transp_Tc5_C PF04236.15 PIK40454.1 - 0.054 13.8 1.5 0.16 12.3 1.5 1.8 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain CDH1_2_SANT_HL1 PF18375.1 PIK40454.1 - 0.27 11.9 2.1 27 5.5 0.0 3.1 3 0 0 3 3 3 0 CDH1/2 SANT-Helical linker 1 Ig_3 PF13927.6 PIK40455.1 - 4.7e-09 36.7 7.0 4.6e-05 23.9 0.0 3.7 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK40455.1 - 3.2e-06 27.3 0.0 3.4e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK40455.1 - 3.3e-05 24.0 6.9 0.00053 20.1 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK40455.1 - 0.00032 20.7 3.5 0.0048 16.9 0.7 2.9 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK40455.1 - 0.00036 20.5 0.0 0.033 14.3 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK40455.1 - 0.005 17.1 6.7 1.2 9.5 0.3 3.8 3 3 0 3 3 3 2 Immunoglobulin domain P_proprotein PF01483.20 PIK40456.1 - 2.1e-28 98.1 0.1 4.8e-28 97.0 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8 PF00082.22 PIK40456.1 - 5.4e-23 81.7 0.2 8.2e-23 81.1 0.2 1.2 1 0 0 1 1 1 1 Subtilase family Integrin_B_tail PF07965.12 PIK40457.1 - 2.5e-12 47.1 7.3 2.5e-12 47.1 7.3 3.9 1 1 1 3 3 3 1 Integrin beta tail domain I-EGF_1 PF18372.1 PIK40457.1 - 0.0001 22.3 4.0 0.0001 22.3 4.0 7.2 8 0 0 8 8 8 3 Integrin beta epidermal growth factor like domain 1 Integrin_b_cyt PF08725.11 PIK40457.1 - 0.00015 21.4 2.5 0.00023 20.7 2.5 1.3 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain EGF_2 PF07974.13 PIK40457.1 - 0.00019 21.7 85.7 0.00025 21.3 13.5 5.9 5 1 1 6 6 6 4 EGF-like domain LapA_dom PF06305.11 PIK40457.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Integrin_beta PF00362.18 PIK40458.1 - 2.6e-31 109.2 0.0 3.3e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_beta PF00362.18 PIK40459.1 - 8.5e-59 199.2 0.0 1.1e-58 198.8 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.3 PIK40459.1 - 2e-12 46.6 9.2 3.6e-12 45.8 9.2 1.4 1 0 0 1 1 1 1 Integrin plexin domain PSI PF01437.25 PIK40459.1 - 0.00014 22.3 4.5 0.00025 21.5 4.5 1.4 1 0 0 1 1 1 1 Plexin repeat Tubulin-binding PF00418.19 PIK40459.1 - 0.021 14.8 0.2 0.44 10.6 0.1 2.7 2 0 0 2 2 2 0 Tau and MAP protein, tubulin-binding repeat DUF1759 PF03564.15 PIK40460.1 - 0.00063 19.7 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DUF5641 PF18701.1 PIK40461.1 - 5.5e-20 71.3 6.0 5.5e-20 71.3 6.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5641) rve PF00665.26 PIK40461.1 - 1.3e-06 28.6 0.0 3.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain C2-set_2 PF08205.12 PIK40462.1 - 2.5e-05 24.3 0.6 0.28 11.3 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK40462.1 - 0.0035 17.7 0.1 0.64 10.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Lipoprotein_17 PF04200.12 PIK40462.1 - 0.036 14.4 0.4 0.26 11.7 0.0 2.1 2 0 0 2 2 2 0 Lipoprotein associated domain NAD_binding_5 PF07994.12 PIK40464.1 - 1.2e-83 281.2 0.0 5.8e-50 170.5 0.0 2.0 1 1 1 2 2 2 2 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 PIK40464.1 - 5.4e-25 87.8 0.1 9.6e-25 87.0 0.1 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Stathmin PF00836.19 PIK40465.1 - 0.00065 19.7 4.0 0.00065 19.7 4.0 2.0 2 0 0 2 2 2 1 Stathmin family zf-CCHC PF00098.23 PIK40465.1 - 0.00079 19.4 3.6 0.00079 19.4 3.6 3.4 3 0 0 3 3 3 1 Zinc knuckle DUF4890 PF16231.5 PIK40465.1 - 0.0064 17.0 4.2 0.0076 16.7 2.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4890) Phage_lysis PF03245.13 PIK40465.1 - 0.27 11.4 4.3 0.63 10.2 4.3 1.6 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DUF883 PF05957.13 PIK40465.1 - 0.44 11.2 1.9 0.54 10.9 0.3 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) SirA PF10747.9 PIK40465.1 - 1 9.7 6.4 2.5 8.4 0.9 2.3 1 1 1 2 2 2 0 Sporulation inhibitor of replication protein SirA Exo_endo_phos PF03372.23 PIK40466.1 - 1.9e-06 27.6 0.2 6.9e-06 25.8 0.2 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK40466.1 - 0.00047 20.0 0.2 0.00047 20.0 0.2 3.4 3 2 1 4 4 4 1 Endonuclease-reverse transcriptase F5_F8_type_C PF00754.25 PIK40466.1 - 0.0037 17.4 0.6 0.01 15.9 0.6 1.7 1 0 0 1 1 1 1 F5/8 type C domain C2-set_2 PF08205.12 PIK40467.1 - 0.0024 17.9 1.9 0.16 12.0 0.1 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK40467.1 - 0.055 14.1 4.4 35 5.1 0.0 4.6 3 1 1 4 4 4 0 Immunoglobulin domain RVT_1 PF00078.27 PIK40468.1 - 1e-46 159.3 0.1 1.4e-46 158.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HECT PF00632.25 PIK40470.1 - 9.4e-94 314.3 0.0 1.2e-93 314.0 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 PIK40470.1 - 2.4e-08 33.9 0.4 6.7e-08 32.5 0.4 1.8 1 0 0 1 1 1 1 WW domain Nuc_sug_transp PF04142.15 PIK40471.1 - 8e-86 288.0 9.1 8.8e-86 287.9 9.1 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 PIK40471.1 - 5.3e-08 32.4 6.5 6.4e-08 32.1 6.5 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 PIK40471.1 - 2.8e-07 30.8 16.4 3.3e-07 30.5 5.2 2.6 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 PIK40471.1 - 3.6e-07 29.7 10.6 4.4e-07 29.4 10.6 1.1 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport TPT PF03151.16 PIK40471.1 - 1.4e-06 27.9 4.4 0.00051 19.5 2.8 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EmrE PF13536.6 PIK40471.1 - 6.4e-06 25.9 1.9 9.3e-06 25.4 1.9 1.3 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter CRT-like PF08627.10 PIK40471.1 - 0.0003 19.9 4.6 0.00037 19.5 4.6 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like DUF202 PF02656.15 PIK40471.1 - 0.043 14.3 0.2 0.18 12.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF202) BacA PF02673.18 PIK40471.1 - 0.045 13.4 3.7 0.13 12.0 0.3 2.2 1 1 1 2 2 2 0 Bacitracin resistance protein BacA Sugar_transport PF06800.12 PIK40471.1 - 0.1 11.9 7.3 0.26 10.6 3.3 1.9 1 1 1 2 2 2 0 Sugar transport protein ATPase_gene1 PF09527.10 PIK40471.1 - 1.7 8.9 7.1 2.2 8.5 0.6 2.7 2 1 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Sulfotransfer_2 PF03567.14 PIK40472.1 - 1.4e-15 57.9 0.2 1.4e-15 57.9 0.2 1.8 2 0 0 2 2 2 1 Sulfotransferase family ACP_PD PF04336.12 PIK40473.1 - 0.012 16.0 0.2 0.053 13.9 0.1 2.0 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase Anti-adapt_IraP PF10796.9 PIK40473.1 - 0.45 11.1 2.2 28 5.4 0.1 3.0 2 1 1 3 3 3 0 Sigma-S stabilisation anti-adaptor protein Vps51 PF08700.11 PIK40474.1 - 1.6e-26 92.2 2.5 8.1e-26 89.9 2.5 2.3 1 0 0 1 1 1 1 Vps51/Vps67 Sec5 PF15469.6 PIK40474.1 - 1.1e-20 74.3 2.0 2.2e-20 73.3 1.5 1.8 1 1 0 1 1 1 1 Exocyst complex component Sec5 Vps54_N PF10475.9 PIK40474.1 - 2.1e-10 40.4 6.4 3.8e-10 39.5 6.4 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Dor1 PF04124.12 PIK40474.1 - 3.7e-10 39.0 6.7 8.1e-10 37.9 6.7 1.6 1 0 0 1 1 1 1 Dor1-like family COG2 PF06148.11 PIK40474.1 - 3.1e-07 30.5 0.9 3.1e-07 30.5 0.9 3.5 3 1 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 PIK40474.1 - 0.00011 22.4 1.7 0.00011 22.4 1.7 2.5 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps53_N PF04100.12 PIK40474.1 - 0.00093 18.3 4.5 0.00093 18.3 4.5 2.1 2 0 0 2 2 2 1 Vps53-like, N-terminal Occludin_ELL PF07303.13 PIK40474.1 - 0.064 14.0 0.3 0.064 14.0 0.3 3.5 3 1 2 5 5 4 0 Occludin homology domain Fib_alpha PF08702.10 PIK40474.1 - 0.18 12.0 9.6 0.44 10.7 0.0 3.2 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family MCPsignal PF00015.21 PIK40474.1 - 0.2 11.5 0.5 0.47 10.3 0.5 1.6 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3375 PF11855.8 PIK40474.1 - 0.23 10.4 5.7 0.19 10.6 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) GIT_CC PF16559.5 PIK40474.1 - 0.36 10.7 6.5 0.52 10.2 0.7 3.4 4 0 0 4 4 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 PIK40474.1 - 0.48 10.9 0.1 0.48 10.9 0.1 4.0 3 1 1 4 4 4 0 Cell division protein ZapB RPW8 PF05659.11 PIK40474.1 - 0.52 10.0 4.9 3.7 7.2 1.4 3.2 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 FliJ PF02050.16 PIK40474.1 - 1.4 9.1 7.9 5.7 7.2 0.3 3.2 3 1 0 3 3 3 0 Flagellar FliJ protein Fez1 PF06818.15 PIK40474.1 - 5.5 7.4 13.0 0.56 10.6 5.7 2.5 1 1 1 2 2 2 0 Fez1 KxDL PF10241.9 PIK40474.1 - 5.7 7.3 7.2 2.6 8.4 2.5 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein HIG_1_N PF04588.13 PIK40475.1 - 2.8e-22 78.7 3.1 3.7e-22 78.3 3.1 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region ETRAMP PF09716.10 PIK40475.1 - 0.055 13.5 0.5 0.93 9.6 0.0 2.1 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF883 PF05957.13 PIK40475.1 - 0.11 13.1 0.1 0.2 12.3 0.0 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF3953 PF13129.6 PIK40475.1 - 2.3 8.1 4.6 2.7 7.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) Arf PF00025.21 PIK40476.1 - 5.7e-43 146.4 0.0 7.1e-43 146.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK40476.1 - 3e-12 46.8 0.0 5.1e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK40476.1 - 2.7e-10 40.1 0.0 3.5e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 PIK40476.1 - 5.9e-09 35.6 0.0 7.5e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK40476.1 - 1.1e-07 31.4 0.0 9.2e-05 21.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 PIK40476.1 - 1.1e-05 25.4 0.2 0.11 12.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 PIK40476.1 - 1.5e-05 24.5 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK40476.1 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 PIK40476.1 - 0.002 18.1 0.3 0.12 12.2 0.3 2.2 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK40476.1 - 0.0031 17.9 1.0 0.039 14.3 1.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK40476.1 - 0.03 14.6 0.0 0.44 10.8 0.0 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK40476.1 - 0.047 14.2 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 PIK40476.1 - 0.065 12.8 0.2 0.2 11.2 0.1 1.7 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 PIK40476.1 - 0.087 12.4 0.6 8.6 5.9 0.1 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.13 PIK40476.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP-synt_E PF05680.12 PIK40477.1 - 2.2e-16 60.0 0.3 2.6e-16 59.7 0.3 1.1 1 0 0 1 1 1 1 ATP synthase E chain 7tm_1 PF00001.21 PIK40478.1 - 4.2e-28 98.4 3.2 7.1e-28 97.7 3.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK40478.1 - 4.7e-06 26.2 22.1 0.0011 18.4 13.6 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK40478.1 - 4.3e-05 23.4 8.6 4.3e-05 23.4 8.6 1.6 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 PIK40478.1 - 0.00013 21.5 12.3 0.00025 20.5 7.4 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv CbiQ PF02361.16 PIK40478.1 - 1.2 8.7 11.6 1.6 8.3 2.0 2.6 2 0 0 2 2 2 0 Cobalt transport protein TnsD PF15978.5 PIK40479.1 - 0.022 13.8 0.1 0.032 13.2 0.1 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D Acyltransferase PF01553.21 PIK40480.1 - 5.7e-13 48.7 0.1 1.5e-12 47.3 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase DUF3473 PF11959.8 PIK40480.1 - 0.088 12.8 0.0 0.51 10.4 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3473) RVT_1 PF00078.27 PIK40481.1 - 0.0095 15.5 0.1 0.013 15.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IFT20 PF14931.6 PIK40482.1 - 0.0082 16.3 0.4 0.0082 16.3 0.4 3.0 4 0 0 4 4 4 1 Intraflagellar transport complex B, subunit 20 POTRA_2 PF08479.11 PIK40482.1 - 0.023 14.5 0.0 0.065 13.1 0.0 1.7 1 0 0 1 1 1 0 POTRA domain, ShlB-type TPR_12 PF13424.6 PIK40483.1 - 2.1e-47 159.3 5.4 2.1e-17 63.1 1.3 6.5 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 PIK40483.1 - 9.2e-27 92.1 10.8 9.1e-07 28.6 0.1 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 PIK40483.1 - 2.6e-19 67.8 11.9 0.0003 20.6 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40483.1 - 3.4e-19 67.8 20.8 0.00044 19.9 0.1 9.5 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK40483.1 - 1.6e-17 63.9 7.2 6.2e-07 29.1 0.1 3.7 1 1 3 4 4 4 4 MalT-like TPR region TPR_2 PF07719.17 PIK40483.1 - 8.7e-16 56.7 22.3 0.0087 16.1 0.1 10.0 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK40483.1 - 1.8e-14 52.6 18.0 0.0033 17.5 0.1 9.4 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK40483.1 - 8e-11 42.4 5.6 2.4e-06 28.1 0.7 5.5 4 2 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK40483.1 - 8e-08 32.1 0.8 8.9 6.9 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40483.1 - 1.1e-07 32.0 16.2 0.082 13.8 0.0 9.1 9 2 1 10 10 8 1 Tetratricopeptide repeat DUF2225 PF09986.9 PIK40483.1 - 2.5e-06 27.4 0.2 0.14 11.9 0.1 3.7 2 2 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 PIK40483.1 - 3e-06 27.7 6.3 0.0004 20.8 0.1 5.1 3 1 2 5 5 5 1 Tetratricopeptide repeat NACHT PF05729.12 PIK40483.1 - 1.4e-05 25.1 0.0 4e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 NACHT domain RPN6_N PF18055.1 PIK40483.1 - 0.0008 19.7 1.4 1.9 8.9 0.1 4.2 1 1 1 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_4 PF07721.14 PIK40483.1 - 0.001 19.5 1.0 7.9 7.4 0.0 5.3 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK40483.1 - 0.002 18.3 3.7 2.3 8.4 0.1 4.8 3 2 1 4 4 4 1 Tetratricopeptide repeat bZIP_1 PF00170.21 PIK40483.1 - 0.0046 17.0 3.6 0.0046 17.0 3.6 3.8 2 1 0 2 2 2 1 bZIP transcription factor AAA_22 PF13401.6 PIK40483.1 - 0.0065 16.7 0.0 0.29 11.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK40483.1 - 0.0083 16.5 1.8 0.076 13.4 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain ANAPC3 PF12895.7 PIK40483.1 - 0.012 15.8 0.8 0.95 9.7 0.1 3.7 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 PIK40483.1 - 0.012 15.8 0.5 6.7 7.2 0.1 4.6 4 0 0 4 4 4 0 PPR repeat JIP_LZII PF16471.5 PIK40483.1 - 0.035 14.3 7.0 0.11 12.7 1.6 3.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II TPR_6 PF13174.6 PIK40483.1 - 0.36 11.6 16.1 4.9 8.0 0.0 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat Spc24 PF08286.11 PIK40483.1 - 3.7 7.8 9.4 1.7 8.9 3.4 3.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 GIT_CC PF16559.5 PIK40483.1 - 4 7.4 11.2 1.3 9.0 1.1 3.5 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3450 PF11932.8 PIK40483.1 - 6.7 5.9 13.5 6 6.1 5.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Trimer_CC PF08954.11 PIK40483.1 - 6.9 6.3 9.9 0.17 11.5 1.2 2.7 2 0 0 2 2 2 0 Trimerisation motif V_ATPase_I PF01496.19 PIK40483.1 - 7.6 4.3 6.5 14 3.4 6.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ThiF PF00899.21 PIK40484.1 - 2.3e-48 164.7 0.3 4.1e-48 163.9 0.1 1.4 1 1 1 2 2 2 1 ThiF family UDPG_MGDP_dh_N PF03721.14 PIK40484.1 - 0.0043 16.7 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 PIK40484.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 PIK40484.1 - 0.11 13.0 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 PIK40484.1 - 0.11 11.7 0.2 0.18 11.0 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain zf-B_box PF00643.24 PIK40485.1 - 1.4e-10 41.2 16.7 4.9e-08 33.0 3.3 4.0 5 0 0 5 5 4 2 B-box zinc finger SGL PF08450.12 PIK40485.1 - 6.5e-06 25.9 0.7 1.8 8.1 0.2 3.2 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 PIK40485.1 - 6.7e-05 22.7 8.4 0.054 13.6 0.5 4.8 4 1 1 5 5 5 2 NHL repeat zf-RING_5 PF14634.6 PIK40485.1 - 0.00019 21.3 8.9 0.00019 21.3 8.9 4.0 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK40485.1 - 0.0002 21.3 5.6 0.0002 21.3 5.6 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK40485.1 - 0.00033 20.7 8.9 0.00033 20.7 8.9 3.6 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK40485.1 - 0.00061 19.6 9.2 0.00061 19.6 9.2 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK40485.1 - 0.0041 16.9 5.9 0.0041 16.9 5.9 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK40485.1 - 0.0072 16.2 6.7 0.0072 16.2 6.7 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) ArlS_N PF18719.1 PIK40485.1 - 0.015 15.5 0.2 1.9 8.7 0.0 2.9 3 0 0 3 3 3 0 ArlS sensor domain DUF3583 PF12126.8 PIK40485.1 - 0.03 13.8 1.6 0.055 12.9 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) CEBP_ZZ PF16366.5 PIK40485.1 - 0.05 13.9 17.7 0.38 11.0 2.2 3.7 3 0 0 3 3 3 0 Cytoplasmic polyadenylation element-binding protein ZZ domain RRF PF01765.19 PIK40485.1 - 0.13 12.2 9.3 0.05 13.5 5.4 2.3 1 1 1 2 2 2 0 Ribosome recycling factor DUF1640 PF07798.11 PIK40485.1 - 0.5 10.4 5.6 1.5 8.9 5.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Siva PF05458.12 PIK40485.1 - 1.5 8.5 24.8 0.073 12.8 2.2 5.0 5 0 0 5 5 5 0 Cd27 binding protein (Siva) Phage_Mu_Gam PF07352.12 PIK40485.1 - 6.3 6.7 10.8 0.24 11.3 2.1 2.7 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein Apolipoprotein PF01442.18 PIK40485.1 - 8.8 6.2 11.6 0.5 10.2 6.1 1.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain SH3_9 PF14604.6 PIK40486.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain Anti-TRAP PF15777.5 PIK40486.1 - 0.13 12.2 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Peptidase_M14 PF00246.24 PIK40487.1 - 3.2e-70 237.2 0.0 4.1e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 PIK40487.1 - 2.6e-10 40.4 0.3 4.2e-10 39.8 0.3 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain AstE_AspA PF04952.14 PIK40487.1 - 3.1e-05 23.2 0.0 6.1e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family CarbopepD_reg_2 PF13715.6 PIK40487.1 - 4.2e-05 23.5 0.0 7.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Peptidase_M14 PF00246.24 PIK40488.1 - 3.8e-68 230.4 0.0 6.6e-68 229.6 0.0 1.4 1 1 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 PIK40488.1 - 5.4e-10 39.4 0.0 9.3e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 PIK40488.1 - 1.5e-07 31.3 0.0 2.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain PEGA PF08308.11 PIK40488.1 - 0.0096 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 PEGA domain Peptidase_M24 PF00557.24 PIK40489.1 - 5.2e-23 81.8 0.1 6.6e-23 81.5 0.1 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 7tm_1 PF00001.21 PIK40490.1 - 7.7e-20 71.3 0.6 1.1e-19 70.9 0.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK40490.1 - 0.00057 19.7 2.8 0.00075 19.3 2.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK40490.1 - 0.0015 18.2 2.8 0.0023 17.6 2.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK40490.1 - 0.0036 16.7 3.1 0.0046 16.4 3.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 PIK40490.1 - 0.069 12.7 5.4 0.12 11.9 5.4 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc OSK PF17182.4 PIK40491.1 - 8.3e-09 35.0 0.2 1.2e-08 34.4 0.2 1.2 1 0 0 1 1 1 1 OSK domain Lipase_GDSL_2 PF13472.6 PIK40491.1 - 2.1e-07 31.5 0.0 2.9e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK40491.1 - 5.5e-07 29.8 0.0 6.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF459 PF04311.13 PIK40491.1 - 0.027 13.5 0.0 0.077 12.0 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF459) PHD PF00628.29 PIK40491.1 - 0.26 11.2 5.8 1.3 8.9 4.6 2.7 2 1 0 2 2 2 0 PHD-finger Med18 PF09637.10 PIK40492.1 - 0.0042 17.0 0.9 0.022 14.6 0.9 1.9 1 1 0 1 1 1 1 Med18 protein RVT_1 PF00078.27 PIK40493.1 - 7.4e-39 133.6 0.6 1.7e-38 132.4 0.5 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK40494.1 - 1.2e-07 31.5 0.0 2.1e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GTP_EFTU_D2 PF03144.25 PIK40494.1 - 0.055 13.9 0.3 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 2 SPACA9 PF15120.6 PIK40495.1 - 4.1e-21 75.4 0.0 5.8e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 WD40 PF00400.32 PIK40496.1 - 7e-24 83.7 0.9 9.9e-08 32.5 0.0 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40496.1 - 0.00042 20.6 0.0 0.049 13.9 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK40496.1 - 0.0013 17.5 1.5 1.1 7.8 0.0 3.5 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 PIK40496.1 - 0.0029 16.6 0.2 1.1 8.1 0.0 2.7 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK40496.1 - 0.071 12.4 0.1 1 8.7 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain Ski2_N PF17911.1 PIK40498.1 - 6.8e-34 116.6 0.0 1.8e-33 115.2 0.0 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 PIK40498.1 - 3.2e-15 56.4 0.0 6.6e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK40498.1 - 2.5e-07 30.9 0.0 5.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 PIK40498.1 - 0.082 12.3 0.1 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DSHCT PF08148.12 PIK40499.1 - 5.3e-45 153.0 0.0 1.2e-44 151.9 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 PIK40499.1 - 1.3e-11 44.9 0.3 2.9e-11 43.8 0.1 1.6 2 0 0 2 2 2 1 rRNA-processing arch domain Ephrin_rec_like PF07699.13 PIK40501.1 - 1.3e-06 28.1 14.8 4.8e-06 26.2 4.3 3.6 2 1 2 4 4 4 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK40501.1 - 0.002 18.0 6.6 0.15 12.0 0.8 2.6 1 1 1 2 2 2 2 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 PIK40501.1 - 0.046 14.1 13.7 0.45 10.9 0.6 4.0 1 1 3 4 4 4 0 TNFR/NGFR cysteine-rich region SUR7 PF06687.12 PIK40502.1 - 0.059 13.0 0.7 0.08 12.6 0.7 1.3 1 0 0 1 1 1 0 SUR7/PalI family LRR_8 PF13855.6 PIK40503.1 - 1.3e-08 34.5 7.7 4e-08 32.9 4.8 2.5 1 1 1 2 2 2 1 Leucine rich repeat Ephrin_rec_like PF07699.13 PIK40503.1 - 1.1e-06 28.3 6.0 1.1e-06 28.3 6.0 4.4 3 1 2 5 5 5 2 Putative ephrin-receptor like LRR_5 PF13306.6 PIK40503.1 - 7.1e-05 22.8 3.3 0.00018 21.5 3.3 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40503.1 - 0.0018 18.6 1.8 0.0018 18.6 1.8 2.9 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) NCD3G PF07562.14 PIK40503.1 - 0.24 11.4 15.4 0.77 9.8 0.3 3.7 2 1 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR LRR_8 PF13855.6 PIK40504.1 - 3e-41 139.0 35.3 9.3e-11 41.3 6.2 6.7 3 2 3 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 PIK40504.1 - 7.1e-19 68.0 22.1 5.6e-08 32.8 1.2 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40504.1 - 1e-12 48.1 39.5 0.0031 17.9 0.5 7.9 4 3 4 8 8 8 5 Leucine Rich repeats (2 copies) Ephrin_rec_like PF07699.13 PIK40504.1 - 9.8e-06 25.2 4.8 9.8e-06 25.2 4.8 4.3 2 1 3 5 5 5 3 Putative ephrin-receptor like LRR_9 PF14580.6 PIK40504.1 - 0.014 14.9 7.1 0.055 13.0 0.7 3.2 2 1 1 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.33 PIK40504.1 - 0.25 12.1 30.6 24 6.0 3.9 9.7 9 2 0 9 9 9 0 Leucine Rich Repeat Ephrin_rec_like PF07699.13 PIK40505.1 - 1.1e-06 28.3 2.1 1.1e-06 28.3 2.1 4.9 3 2 4 7 7 7 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK40505.1 - 8.5 6.4 26.0 1.3 9.1 0.8 4.1 4 0 0 4 4 4 0 Nine Cysteines Domain of family 3 GPCR Beta-lactamase PF00144.24 PIK40506.1 - 6.3e-55 186.7 0.0 8.5e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase LRR_8 PF13855.6 PIK40507.1 - 5.7e-25 86.8 31.0 2.4e-09 36.8 4.2 5.7 2 1 4 6 6 6 5 Leucine rich repeat LRR_5 PF13306.6 PIK40507.1 - 6.5e-10 39.1 10.2 2.5e-05 24.2 1.2 3.2 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40507.1 - 4.3e-05 23.8 29.9 0.13 12.7 0.3 6.2 4 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK40507.1 - 0.00012 21.6 4.4 0.013 15.1 0.3 2.5 1 1 1 2 2 2 2 Leucine-rich repeat Exo_endo_phos_2 PF14529.6 PIK40508.1 - 0.00034 20.4 0.0 0.00069 19.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK40508.1 - 0.0053 16.3 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peroxin-3 PF04882.12 PIK40508.1 - 0.045 12.7 3.3 0.066 12.2 3.3 1.1 1 0 0 1 1 1 0 Peroxin-3 LRR_8 PF13855.6 PIK40509.1 - 1.6e-99 325.6 142.8 3.3e-13 49.2 1.1 13.0 1 1 18 19 19 19 19 Leucine rich repeat LRR_5 PF13306.6 PIK40509.1 - 1.3e-50 170.6 28.9 7.7e-12 45.3 0.4 5.7 1 1 5 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK40509.1 - 8.8e-38 127.7 93.9 0.00011 22.6 0.1 15.4 10 4 3 16 16 16 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK40509.1 - 7e-21 74.5 36.8 0.0001 21.8 0.9 7.5 3 3 5 8 8 8 6 Leucine-rich repeat LRR_6 PF13516.6 PIK40509.1 - 0.00041 20.2 43.9 7.1 7.0 0.0 15.3 17 0 0 17 17 17 2 Leucine Rich repeat LRR_1 PF00560.33 PIK40509.1 - 0.0013 19.0 64.1 3.9 8.4 0.2 18.5 20 2 1 21 21 20 2 Leucine Rich Repeat Ephrin_rec_like PF07699.13 PIK40509.1 - 0.0015 18.3 16.6 0.0049 16.6 6.4 3.0 1 1 2 3 3 3 3 Putative ephrin-receptor like YtpI PF14007.6 PIK40509.1 - 0.031 14.4 0.1 0.091 12.9 0.1 1.8 1 0 0 1 1 1 0 YtpI-like protein NCD3G PF07562.14 PIK40509.1 - 0.054 13.5 7.1 0.18 11.8 0.8 2.4 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR DUF5009 PF16401.5 PIK40509.1 - 0.067 12.7 2.0 0.16 11.4 1.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5009) DUF996 PF06195.13 PIK40509.1 - 0.077 13.3 1.9 1.6 9.0 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF996) LRRNT PF01462.18 PIK40509.1 - 0.085 12.5 1.0 0.9 9.3 0.2 3.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Ac76 PF05814.11 PIK40509.1 - 4 7.5 6.6 0.33 11.0 0.1 2.5 3 0 0 3 3 3 0 Orf76 (Ac76) Tetraspanin PF00335.20 PIK40510.1 - 1.9e-26 93.2 5.9 2.6e-26 92.8 5.9 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF373 PF04123.13 PIK40510.1 - 1.7 8.0 7.2 0.28 10.6 3.7 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF373) Macoilin PF09726.9 PIK40510.1 - 8.3 4.8 11.0 11 4.4 11.0 1.2 1 0 0 1 1 1 0 Macoilin family TBCC PF07986.12 PIK40511.1 - 4.8e-43 145.7 0.3 7e-43 145.2 0.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 PIK40511.1 - 4.8e-25 88.2 3.5 7.9e-25 87.6 3.5 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain CAP_C PF08603.11 PIK40511.1 - 0.0022 17.6 0.3 0.0042 16.7 0.3 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal APC_u15 PF16636.5 PIK40511.1 - 0.36 11.3 6.7 0.57 10.6 1.8 2.5 2 0 0 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 Sulfatase PF00884.23 PIK40512.1 - 4e-64 216.9 0.0 4.8e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 PIK40512.1 - 0.0081 14.8 0.1 0.012 14.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 PIK40512.1 - 0.036 13.6 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK40513.1 - 8.8e-19 68.0 0.0 9.5e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK40513.1 - 0.016 14.8 0.2 0.028 14.0 0.1 1.4 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK40514.1 - 2.8e-21 76.2 0.0 3.5e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 PIK40514.1 - 0.0039 16.3 0.0 0.0054 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Phosphodiest PF01663.22 PIK40514.1 - 0.099 12.2 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK40514.1 - 0.15 10.7 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) RuBisCo_chap_C PF18087.1 PIK40515.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Rubisco Assembly chaperone C-terminal domain Myosin_head PF00063.21 PIK40516.1 - 6.7e-195 649.2 0.0 6.7e-195 649.2 0.0 3.5 3 1 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 PIK40516.1 - 1.9e-162 542.6 265.3 2.3e-162 542.3 265.3 1.0 1 0 0 1 1 1 1 Myosin tail ERM PF00769.19 PIK40516.1 - 0.0037 17.1 38.9 0.0037 17.1 38.9 8.3 1 1 5 8 8 8 3 Ezrin/radixin/moesin family Laminin_II PF06009.12 PIK40516.1 - 0.0044 17.0 14.2 0.0044 17.0 14.2 12.4 3 2 8 12 12 12 4 Laminin Domain II Filament PF00038.21 PIK40516.1 - 0.041 13.5 226.8 0.037 13.6 47.9 9.3 1 1 4 7 7 7 0 Intermediate filament protein IQ PF00612.27 PIK40516.1 - 1.3 9.1 4.9 3.6 7.6 0.3 3.0 2 0 0 2 2 2 0 IQ calmodulin-binding motif Phage_T4_gp19 PF06841.12 PIK40516.1 - 6.4 6.6 8.7 9.3 6.1 0.4 3.7 4 0 0 4 4 4 0 T4-like virus tail tube protein gp19 V-set PF07686.17 PIK40517.1 - 2.3e-10 40.6 0.5 0.00041 20.5 0.0 3.5 4 0 0 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 PIK40517.1 - 1e-08 35.2 1.4 0.24 11.6 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.6 PIK40517.1 - 5.2e-07 30.2 1.3 0.81 10.3 0.0 4.6 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK40517.1 - 0.00015 22.0 1.0 1.7 9.1 0.0 4.5 4 1 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK40517.1 - 0.0002 21.3 0.4 0.25 11.5 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain EphA2_TM PF14575.6 PIK40517.1 - 0.15 13.0 0.2 0.52 11.2 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ribosomal_S7e PF01251.18 PIK40518.1 - 5.4e-67 225.1 7.3 7.4e-67 224.7 7.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e AlbA_2 PF04326.14 PIK40518.1 - 3.5 8.0 5.0 14 6.0 0.3 2.7 2 1 1 3 3 3 0 Putative DNA-binding domain RNase_H PF00075.24 PIK40519.1 - 1.4e-43 148.5 0.1 2.3e-43 147.8 0.1 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 PIK40519.1 - 8.6e-18 64.4 5.3 1.7e-17 63.4 5.3 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.6 PIK40519.1 - 2.2e-08 33.9 0.0 7.3e-08 32.3 0.1 1.9 2 0 0 2 2 2 1 Reverse transcriptase-like Peptidase_C26 PF07722.13 PIK40520.1 - 3.1e-20 72.8 0.0 7.2e-20 71.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 PIK40520.1 - 2.3e-09 37.3 0.0 3.8e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 PIK40520.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.6 1 1 0 1 1 1 0 SNO glutamine amidotransferase family RVT_1 PF00078.27 PIK40521.1 - 2.3e-44 151.6 0.1 3.4e-44 151.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK40521.1 - 3.2e-06 27.0 19.4 0.0045 17.0 3.8 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK40521.1 - 0.0016 18.2 18.2 0.46 10.2 2.4 3.6 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK40521.1 - 0.039 13.8 19.4 0.27 11.1 0.2 3.9 3 0 0 3 3 3 0 Zinc knuckle Inhibitor_G39P PF11417.8 PIK40521.1 - 0.16 12.5 0.0 0.56 10.8 0.0 2.0 1 0 0 1 1 1 0 Loader and inhibitor of phage G40P zf-C2H2_10 PF16588.5 PIK40521.1 - 1.7 8.5 10.0 1.5 8.6 2.3 2.7 2 0 0 2 2 2 0 C2H2 zinc-finger Lin-8 PF03353.15 PIK40521.1 - 2.4 7.6 8.5 3.9 7.0 8.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DZR PF12773.7 PIK40521.1 - 4.8 7.3 13.6 15 5.7 13.6 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RVT PF13966.6 PIK40522.1 - 4.6e-09 36.9 0.6 4.6e-09 36.9 0.6 1.9 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Peptidase_C26 PF07722.13 PIK40523.1 - 6.4e-14 52.2 0.0 3.2e-13 49.9 0.0 1.8 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 PIK40523.1 - 7.1e-06 25.9 0.0 9.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_5 PF13507.6 PIK40523.1 - 0.011 14.9 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Pkinase PF00069.25 PIK40524.1 - 2.4e-14 53.3 0.0 3.3e-11 43.0 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40524.1 - 9.1e-08 31.7 0.0 0.0015 17.9 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase PAPS_reduct PF01507.19 PIK40525.1 - 7.4e-26 91.2 0.0 2.6e-24 86.2 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family MoCF_biosynth PF00994.24 PIK40525.1 - 4.7e-15 55.5 0.0 7.9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain FAM76 PF16046.5 PIK40526.1 - 0.018 14.4 2.1 0.024 14.0 2.1 1.2 1 0 0 1 1 1 0 FAM76 protein DUF16 PF01519.16 PIK40526.1 - 0.099 13.1 4.7 0.12 12.9 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 TEX13 PF15186.6 PIK40526.1 - 2.3 7.9 7.9 4 7.1 7.9 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family ADIP PF11559.8 PIK40526.1 - 9.5 6.3 15.8 0.22 11.6 4.6 2.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding RVT_1 PF00078.27 PIK40527.1 - 8e-09 35.3 0.0 7.7e-07 28.8 0.0 2.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK40527.1 - 3.8e-05 23.9 0.0 0.00043 20.5 0.0 2.6 3 0 0 3 3 3 1 GIY-YIG catalytic domain PRANC PF09372.10 PIK40527.1 - 0.00035 20.8 1.2 1.6 9.1 0.1 3.0 2 0 0 2 2 2 2 PRANC domain Arm-DNA-bind_2 PF12167.8 PIK40527.1 - 0.0043 16.9 0.0 6.8 6.7 0.0 3.0 3 0 0 3 3 3 2 Arm DNA-binding domain Glyco_transf_11 PF01531.16 PIK40527.1 - 0.019 14.2 0.8 1.4 8.1 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 11 DUF2922 PF11148.8 PIK40527.1 - 0.083 12.6 0.5 76 3.1 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2922) Zap1_zf2 PF18217.1 PIK40527.1 - 0.21 11.6 4.8 9.9 6.3 0.4 2.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 DUF1848 PF08902.11 PIK40527.1 - 0.33 10.6 7.6 0.88 9.2 2.8 3.7 5 0 0 5 5 5 0 Domain of unknown function (DUF1848) DAO PF01266.24 PIK40528.1 - 2e-12 47.4 0.0 2.3e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Ribosomal_L5 PF00281.19 PIK40528.1 - 0.02 15.2 0.0 6 7.3 0.0 2.6 2 1 0 2 2 2 0 Ribosomal protein L5 DUF2152 PF10222.9 PIK40529.1 - 9.2e-93 311.6 0.2 1.2e-92 311.3 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) PNMA PF14893.6 PIK40530.1 - 2e-12 47.2 0.2 2e-12 47.2 0.2 1.6 1 1 1 2 2 2 1 PNMA zf-CCHC PF00098.23 PIK40530.1 - 2.8e-05 24.0 0.7 4.7e-05 23.3 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK40530.1 - 0.0022 18.2 0.3 0.025 14.9 0.0 2.5 1 1 2 3 3 3 1 Retrotransposon gag protein RT_RNaseH_2 PF17919.1 PIK40531.1 - 1.3e-26 92.6 0.0 3.4e-26 91.2 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40531.1 - 6.7e-26 91.2 0.0 1.7e-25 89.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK40531.1 - 9.2e-15 54.8 0.0 3e-14 53.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK40532.1 - 2.1e-14 53.7 0.0 3.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40532.1 - 0.00021 21.3 0.1 0.00039 20.5 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain DAO PF01266.24 PIK40534.1 - 3e-26 92.9 0.0 3.7e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK40534.1 - 0.008 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pro_dh PF01619.18 PIK40535.1 - 3.2e-70 237.0 0.3 4.1e-70 236.7 0.3 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Arm PF00514.23 PIK40536.1 - 6.1e-12 45.1 0.2 0.0076 16.3 0.0 5.8 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 PIK40536.1 - 8.2e-06 25.3 4.5 1.5e-05 24.5 1.1 2.4 1 1 1 2 2 2 1 V-ATPase subunit H HEAT_2 PF13646.6 PIK40536.1 - 0.033 14.6 0.0 2.4 8.6 0.0 2.9 2 0 0 2 2 2 0 HEAT repeats HrpA_pilin PF09589.10 PIK40536.1 - 5.5 7.8 7.4 15 6.4 3.1 2.6 2 0 0 2 2 2 0 HrpA pilus formation protein RhoGEF PF00621.20 PIK40537.1 - 3.4e-27 95.8 2.8 1e-26 94.3 2.0 2.2 2 0 0 2 2 2 1 RhoGEF domain RhoGAP PF00620.27 PIK40537.1 - 1.1e-24 87.0 0.2 7e-23 81.1 0.0 2.9 2 1 0 2 2 2 1 RhoGAP domain C2 PF00168.30 PIK40537.1 - 2.3e-07 31.1 0.0 4.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.29 PIK40537.1 - 0.00087 19.8 1.0 0.0063 17.0 1.0 2.3 1 1 0 1 1 1 1 PH domain VPS28 PF03997.12 PIK40537.1 - 0.0019 17.9 2.0 0.35 10.5 0.0 2.7 2 0 0 2 2 2 2 VPS28 protein Phage_antiter_Q PF06323.11 PIK40537.1 - 0.0021 17.7 0.1 0.0043 16.6 0.1 1.5 1 0 0 1 1 1 1 Phage antitermination protein Q Pox_A_type_inc PF04508.12 PIK40537.1 - 0.06 13.2 3.9 0.5 10.3 1.1 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat RepA1_leader PF08048.12 PIK40537.1 - 0.19 12.0 1.2 0.45 10.8 1.2 1.6 1 0 0 1 1 1 0 Tap RepA1 leader peptide DUF1917 PF08939.10 PIK40537.1 - 0.77 9.6 4.2 1.9 8.3 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1917) HR1 PF02185.16 PIK40537.1 - 3.4 7.9 7.9 50 4.1 0.2 3.8 2 1 1 3 3 3 0 Hr1 repeat 7tm_1 PF00001.21 PIK40538.1 - 3.9e-24 85.4 1.2 1.3e-13 50.9 0.8 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) OPT PF03169.15 PIK40538.1 - 0.052 12.2 0.1 0.052 12.2 0.1 2.2 2 1 0 2 2 2 0 OPT oligopeptide transporter protein DUF5345 PF17280.2 PIK40538.1 - 1.2 9.1 3.8 2 8.5 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF3487 PF11990.8 PIK40538.1 - 1.8 8.4 5.5 8.2 6.4 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3487) V-set PF07686.17 PIK40540.1 - 9.1e-05 22.6 0.7 0.00049 20.3 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain MBG PF17883.1 PIK40540.1 - 0.0076 16.8 0.1 0.024 15.3 0.1 1.8 2 0 0 2 2 2 1 MBG domain I-set PF07679.16 PIK40540.1 - 0.03 14.4 0.2 0.27 11.3 0.0 2.3 2 1 1 3 3 3 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40540.1 - 0.044 14.4 1.0 10 6.8 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK40540.1 - 0.06 13.5 0.6 0.22 11.7 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain RVT_1 PF00078.27 PIK40541.1 - 3.8e-05 23.3 0.0 5.2e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.17 PIK40545.1 - 1.6e-23 83.4 0.0 2.4e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 PIK40545.1 - 1.5e-15 57.0 4.5 3.8e-06 26.9 0.0 4.6 3 1 1 4 4 4 4 CD80-like C2-set immunoglobulin domain Pkinase PF00069.25 PIK40545.1 - 1.4e-14 54.1 0.0 2.3e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK40545.1 - 4.5e-05 23.7 11.8 0.013 15.8 0.7 5.3 5 0 0 5 5 5 1 Immunoglobulin domain Ig_3 PF13927.6 PIK40545.1 - 0.00024 21.6 8.6 0.8 10.4 0.1 5.4 4 1 0 5 5 5 1 Immunoglobulin domain ig PF00047.25 PIK40545.1 - 0.0031 17.6 3.6 0.2 11.9 0.4 4.1 4 0 0 4 4 4 1 Immunoglobulin domain NACHT PF05729.12 PIK40546.1 - 2.1e-17 63.6 0.1 2e-16 60.3 0.0 2.5 3 0 0 3 3 3 1 NACHT domain NB-ARC PF00931.22 PIK40546.1 - 0.0015 17.8 0.2 0.0046 16.2 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_25 PF13481.6 PIK40546.1 - 0.026 14.1 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain GPI2 PF06432.11 PIK40546.1 - 0.039 13.4 2.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_22 PF13401.6 PIK40546.1 - 0.051 13.9 0.1 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF5457 PF17540.2 PIK40546.1 - 0.064 13.4 1.2 8.3 6.6 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5457) DUF1677 PF07911.13 PIK40546.1 - 0.079 13.3 0.0 0.92 9.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1677) AAA_16 PF13191.6 PIK40546.1 - 0.11 12.9 0.0 0.36 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain RT_RNaseH_2 PF17919.1 PIK40547.1 - 3.2e-17 62.4 0.0 4.6e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40547.1 - 4.7e-05 23.6 0.0 8.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK40547.1 - 0.00047 19.7 0.0 0.00079 19.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK40548.1 - 3e-09 36.5 0.0 5.6e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 PIK40548.1 - 2.3e-05 24.6 0.0 4.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 PIK40548.1 - 0.00085 19.4 0.1 0.0016 18.5 0.1 1.4 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain E3_UFM1_ligase PF09743.9 PIK40550.1 - 1.3e-52 179.2 5.7 1.5e-52 178.9 5.7 1.0 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 HTH_53 PF18606.1 PIK40550.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain E3_UFM1_ligase PF09743.9 PIK40551.1 - 2.4e-33 115.9 0.0 6e-33 114.6 0.0 1.7 2 0 0 2 2 2 1 E3 UFM1-protein ligase 1 Glucosamine_iso PF01182.20 PIK40551.1 - 0.055 13.3 0.1 0.09 12.6 0.1 1.3 1 0 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase T-box PF00907.22 PIK40552.1 - 8.9e-73 244.5 0.0 1.6e-72 243.6 0.0 1.4 1 0 0 1 1 1 1 T-box Bac_rhamnosid PF05592.11 PIK40552.1 - 0.005 16.8 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Foie-gras_1 PF11817.8 PIK40554.1 - 1.5e-05 24.7 0.3 1.8e-05 24.5 0.3 1.1 1 0 0 1 1 1 1 Foie gras liver health family 1 TPR_12 PF13424.6 PIK40554.1 - 4.4e-05 23.7 0.2 9e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat SNAP PF14938.6 PIK40554.1 - 0.00012 21.6 0.2 0.00036 20.0 0.1 1.8 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 PIK40554.1 - 0.00084 19.1 0.2 0.0027 17.5 0.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF2225 PF09986.9 PIK40554.1 - 0.0071 16.1 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.6 PIK40554.1 - 0.044 14.6 0.1 0.14 13.0 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK40554.1 - 0.05 13.8 0.4 0.17 12.2 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Mad3_BUB1_I_2 PF17014.5 PIK40554.1 - 0.058 13.5 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein Wzy_C_2 PF11846.8 PIK40554.1 - 0.079 12.9 0.3 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_1 PF00515.28 PIK40554.1 - 0.13 12.1 0.7 0.44 10.4 0.7 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TRAPPC10 PF12584.8 PIK40555.1 - 3.8e-14 52.7 0.0 9.4e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 RhoGAP PF00620.27 PIK40556.1 - 1.8e-20 73.3 0.1 3.7e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 RhoGAP domain Exo_endo_phos PF03372.23 PIK40557.1 - 0.026 14.0 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family INPP5B_PH PF16776.5 PIK40558.1 - 0.004 16.9 0.0 0.005 16.6 0.0 1.1 1 0 0 1 1 1 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain HECT_2 PF09814.9 PIK40559.1 - 4e-21 75.3 7.6 6.2e-21 74.7 7.6 1.2 1 1 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 PIK40559.1 - 0.005 17.0 1.3 1.8 8.8 0.1 2.5 2 0 0 2 2 2 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH_5 PF14279.6 PIK40559.1 - 0.007 16.2 3.6 2.4 8.1 0.7 2.7 2 0 0 2 2 2 2 HNH endonuclease Ribosomal_L44 PF00935.19 PIK40559.1 - 0.27 11.8 3.7 13 6.4 0.2 2.5 2 0 0 2 2 2 0 Ribosomal protein L44 Zn-ribbon_8 PF09723.10 PIK40559.1 - 1.5 9.0 3.7 15 5.8 0.2 3.2 3 0 0 3 3 3 0 Zinc ribbon domain HNH PF01844.23 PIK40559.1 - 1.7 8.9 8.5 0.71 10.1 0.5 3.1 3 0 0 3 3 3 0 HNH endonuclease Rhodanese_C PF12368.8 PIK40559.1 - 6.4 7.2 7.7 1.1 9.6 1.6 2.8 3 0 0 3 3 3 0 Rhodanase C-terminal SDF PF00375.18 PIK40562.1 - 3e-44 151.6 10.7 8.5e-33 113.9 10.8 2.0 2 0 0 2 2 2 2 Sodium:dicarboxylate symporter family DUF1240 PF06836.12 PIK40562.1 - 0.96 10.0 4.3 4.9 7.7 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1240) Orf78 PF06024.12 PIK40563.1 - 0.0077 16.5 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Orf78 (ac78) TMEM154 PF15102.6 PIK40563.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family SUR7 PF06687.12 PIK40563.1 - 0.057 13.0 0.1 0.078 12.6 0.1 1.1 1 0 0 1 1 1 0 SUR7/PalI family Syndecan PF01034.20 PIK40563.1 - 0.065 13.2 0.9 0.1 12.5 0.9 1.3 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 PIK40563.1 - 0.077 13.9 0.0 0.11 13.5 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Insulin_TMD PF17870.1 PIK40563.1 - 0.087 12.9 0.8 0.18 11.9 0.8 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RCR PF12273.8 PIK40563.1 - 0.1 13.2 0.0 0.17 12.5 0.0 1.3 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RVT_1 PF00078.27 PIK40564.1 - 3.5e-22 79.0 0.0 4.9e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK40564.1 - 1e-05 25.0 0.0 0.00016 21.2 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) VPS9 PF02204.18 PIK40565.1 - 0.00016 21.8 0.2 0.00043 20.4 0.2 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain NDK PF00334.19 PIK40566.1 - 2.4e-113 374.0 0.2 7.6e-36 123.1 0.0 4.2 3 1 1 4 4 4 4 Nucleoside diphosphate kinase Thioredoxin PF00085.20 PIK40566.1 - 3.2e-08 33.5 0.0 8.6e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin MutL_C PF08676.11 PIK40566.1 - 0.045 13.5 1.4 2.5 7.9 0.3 2.6 2 0 0 2 2 2 0 MutL C terminal dimerisation domain PT PF04886.12 PIK40566.1 - 0.072 12.6 7.3 0.18 11.3 7.3 1.6 1 0 0 1 1 1 0 PT repeat DUF4252 PF14060.6 PIK40566.1 - 1.1 9.2 3.2 0.77 9.6 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) DUF2201_N PF13203.6 PIK40566.1 - 9.7 5.7 0.0 9.7 5.7 0.0 4.2 2 1 2 4 4 4 0 Putative metallopeptidase domain VPS9 PF02204.18 PIK40567.1 - 4.7e-07 30.0 0.1 1.1e-06 28.8 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain IFT20 PF14931.6 PIK40568.1 - 0.0058 16.8 0.3 0.0058 16.8 0.3 2.6 3 0 0 3 3 3 1 Intraflagellar transport complex B, subunit 20 bZIP_1 PF00170.21 PIK40570.1 - 0.00078 19.5 4.5 0.0034 17.5 4.5 2.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK40570.1 - 0.013 15.5 3.8 0.05 13.7 3.8 2.1 1 0 0 1 1 1 0 Basic region leucine zipper GIT_CC PF16559.5 PIK40570.1 - 0.063 13.2 1.6 0.56 10.1 1.2 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2730 PF10805.8 PIK40570.1 - 0.13 12.4 0.8 0.34 11.0 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) JIP_LZII PF16471.5 PIK40570.1 - 0.19 11.9 6.5 0.11 12.7 3.0 2.6 1 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Trimer_CC PF08954.11 PIK40570.1 - 0.21 11.2 4.5 0.072 12.6 1.2 1.9 2 0 0 2 2 2 0 Trimerisation motif HALZ PF02183.18 PIK40570.1 - 0.27 11.5 8.6 0.11 12.7 3.3 3.0 2 1 1 3 3 3 0 Homeobox associated leucine zipper Ribosomal_S24e PF01282.19 PIK40570.1 - 0.36 10.8 1.6 0.44 10.5 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein S24e Spc24 PF08286.11 PIK40570.1 - 0.43 10.9 5.1 2 8.7 4.9 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Uso1_p115_C PF04871.13 PIK40570.1 - 1 9.7 10.5 0.84 10.0 8.3 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMF_TATA_bd PF12325.8 PIK40570.1 - 1.6 9.0 12.9 0.35 11.1 8.3 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding GrpE PF01025.19 PIK40570.1 - 1.6 8.3 12.5 5.5 6.6 12.5 1.9 1 1 0 1 1 1 0 GrpE V_ATPase_I PF01496.19 PIK40570.1 - 2.7 5.8 6.3 4.2 5.2 6.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 PIK40570.1 - 2.8 7.2 5.4 4.2 6.6 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 PIK40570.1 - 3.5 8.1 18.0 1.1 9.8 13.2 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 PIK40570.1 - 5 7.4 12.5 16 5.8 3.5 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cep57_CLD_2 PF14197.6 PIK40570.1 - 9.8 6.4 17.9 1.8 8.7 11.7 3.0 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 TPR_12 PF13424.6 PIK40571.1 - 4.3e-47 158.3 7.2 8.7e-18 64.4 1.3 5.8 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 PIK40571.1 - 1e-30 104.7 5.0 3.9e-07 29.7 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40571.1 - 1.8e-21 75.0 16.7 0.00019 21.1 0.1 8.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK40571.1 - 2.7e-20 70.8 12.4 0.00013 21.8 0.1 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 PIK40571.1 - 9.1e-17 59.8 21.1 0.0037 17.3 0.1 8.2 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK40571.1 - 7.9e-16 58.4 6.9 2.4e-07 30.5 0.1 3.7 1 1 3 4 4 4 4 MalT-like TPR region TPR_8 PF13181.6 PIK40571.1 - 8.8e-14 50.5 19.1 0.0014 18.6 0.1 8.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40571.1 - 1.3e-11 44.3 7.0 0.034 15.0 0.0 7.8 7 1 1 8 8 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK40571.1 - 1.5e-09 38.3 12.0 1e-06 29.3 0.8 5.7 6 2 0 6 6 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK40571.1 - 1.8e-08 34.2 3.7 3.5 8.2 0.0 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK40571.1 - 6.9e-08 32.9 6.0 0.00016 22.1 0.1 5.0 3 2 3 6 6 6 1 Tetratricopeptide repeat RPN6_N PF18055.1 PIK40571.1 - 0.0002 21.7 1.6 2.1 8.7 0.0 4.0 1 1 3 4 4 4 1 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_9 PF13371.6 PIK40571.1 - 0.00028 21.0 3.1 1.2 9.4 0.1 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 PIK40571.1 - 0.00042 20.7 3.8 3.4 8.6 0.0 5.6 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK40571.1 - 0.0027 18.3 14.7 2.1 9.1 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat DUF2225 PF09986.9 PIK40571.1 - 0.0033 17.2 4.4 0.15 11.7 0.1 3.4 1 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) PPR PF01535.20 PIK40571.1 - 0.0094 16.1 3.4 2.9 8.3 0.1 5.2 6 0 0 6 6 5 1 PPR repeat ANAPC3 PF12895.7 PIK40571.1 - 0.01 16.1 3.7 0.38 11.0 0.1 4.3 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK40571.1 - 0.041 13.6 2.0 73 3.2 0.0 5.2 5 0 0 5 5 5 0 TPR repeat Tropomyosin_1 PF12718.7 PIK40571.1 - 0.055 13.6 0.4 0.13 12.4 0.4 1.6 1 0 0 1 1 1 0 Tropomyosin like Tcf25 PF04910.14 PIK40571.1 - 0.094 11.8 0.8 0.41 9.7 0.0 2.1 2 0 0 2 2 2 0 Transcriptional repressor TCF25 DUF4810 PF16068.5 PIK40571.1 - 0.27 11.8 4.1 20 5.8 0.0 4.8 5 1 1 6 6 5 0 Domain of unknown function (DUF4810) ThiF PF00899.21 PIK40572.1 - 3.3e-48 164.2 0.1 5.3e-48 163.5 0.1 1.2 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 PIK40572.1 - 0.005 16.4 0.0 0.0085 15.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 PIK40572.1 - 0.086 13.3 0.0 0.38 11.2 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 PIK40572.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 PIK40572.1 - 0.12 11.5 0.2 0.2 10.8 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain 5-FTHF_cyc-lig PF01812.20 PIK40573.1 - 1.5e-47 161.9 0.0 1.7e-47 161.7 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family DUF5532 PF17673.1 PIK40573.1 - 0.11 12.6 0.2 0.24 11.5 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5532) Dynactin_p22 PF07426.11 PIK40574.1 - 8.8e-50 168.8 10.1 1e-49 168.6 10.1 1.1 1 0 0 1 1 1 1 Dynactin subunit p22 Rb_C PF08934.10 PIK40574.1 - 0.016 15.0 0.1 0.034 14.0 0.0 1.6 2 0 0 2 2 2 0 Rb C-terminal domain Sec34 PF04136.15 PIK40574.1 - 0.04 13.8 5.3 1.5 8.7 1.6 2.1 2 0 0 2 2 2 0 Sec34-like family Retrotrans_gag PF03732.17 PIK40574.1 - 0.23 11.8 1.9 0.76 10.1 0.2 2.6 1 1 2 3 3 3 0 Retrotransposon gag protein DUF4404 PF14357.6 PIK40574.1 - 5.1 7.8 12.4 2.9 8.6 2.4 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) Pro_isomerase PF00160.21 PIK40575.1 - 2.8e-47 160.9 0.4 3.4e-47 160.7 0.4 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4059 PF13268.6 PIK40575.1 - 0.18 12.3 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) Epiglycanin_TR PF05647.11 PIK40576.1 - 0.035 14.0 0.9 0.068 13.1 0.3 1.8 1 1 0 1 1 1 0 Tandem-repeating region of mucin, epiglycanin-like GWT1 PF06423.12 PIK40577.1 - 0.13 12.4 2.0 0.45 10.6 0.1 2.1 1 1 0 2 2 2 0 GWT1 TIG_2 PF18020.1 PIK40578.1 - 1.1e-12 48.4 0.0 2.5e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 TIG domain found in plexin TIG PF01833.24 PIK40578.1 - 1.6e-10 40.9 6.4 4.6e-05 23.4 0.1 3.0 3 0 0 3 3 3 2 IPT/TIG domain PSI PF01437.25 PIK40578.1 - 0.017 15.7 11.0 0.034 14.7 11.0 1.5 1 0 0 1 1 1 0 Plexin repeat Sema PF01403.19 PIK40579.1 - 5.8e-37 127.5 0.0 3.3e-33 115.1 0.0 2.3 2 1 0 2 2 2 2 Sema domain PSI PF01437.25 PIK40579.1 - 2.8e-08 34.2 16.1 6.9e-08 32.9 16.1 1.7 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 PIK40579.1 - 0.3 10.8 11.4 0.67 9.7 11.4 1.6 1 0 0 1 1 1 0 Integrin plexin domain Pkinase_Tyr PF07714.17 PIK40580.1 - 4.6e-34 117.9 0.1 5.7e-25 88.1 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK40580.1 - 5.8e-11 42.3 0.0 2.1e-06 27.3 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Sema PF01403.19 PIK40581.1 - 1.2e-43 149.6 0.0 2e-43 148.8 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 PIK40581.1 - 2e-27 95.1 36.4 6.1e-09 35.8 0.7 6.9 7 0 0 7 7 7 4 IPT/TIG domain PSI PF01437.25 PIK40581.1 - 5.7e-09 36.4 37.6 2e-07 31.5 16.1 3.1 3 0 0 3 3 3 2 Plexin repeat TIG_2 PF18020.1 PIK40581.1 - 1.1e-07 32.3 0.1 0.0002 21.9 0.0 2.9 2 0 0 2 2 2 2 TIG domain found in plexin TIG_plexin PF17960.1 PIK40581.1 - 5e-06 26.4 2.7 0.00085 19.3 0.4 3.3 2 0 0 2 2 2 2 TIG domain 7tm_1 PF00001.21 PIK40583.1 - 6.3e-29 101.1 19.2 7.9e-29 100.8 19.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK40583.1 - 1.3e-08 34.8 19.9 1.3e-08 34.8 19.9 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK40583.1 - 0.0016 17.9 21.0 0.0024 17.3 21.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK40584.1 - 3.8e-28 98.5 17.0 5.1e-28 98.1 17.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK40584.1 - 3.5e-06 26.8 21.9 3.5e-06 26.8 21.9 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Lactamase_B PF00753.27 PIK40585.1 - 3.4e-15 56.6 2.6 1.6e-14 54.4 2.6 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK40585.1 - 0.00019 21.0 0.4 0.00032 20.3 0.4 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Helicase_C PF00271.31 PIK40586.1 - 1.3e-12 48.0 0.0 2.8e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RIG-I_C-RD PF11648.8 PIK40586.1 - 0.19 11.9 0.6 0.19 11.9 0.6 1.9 2 0 0 2 2 2 0 C-terminal domain of RIG-I RIG-I_C PF18119.1 PIK40587.1 - 9.5e-21 74.3 0.0 2e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 RIG-I receptor C-terminal domain ResIII PF04851.15 PIK40587.1 - 6.9e-16 58.7 0.0 1.8e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK40587.1 - 1.9e-15 57.0 0.0 4e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD_2 PF16739.5 PIK40587.1 - 3.9e-12 46.0 0.1 1.3e-09 37.9 0.0 2.8 2 0 0 2 2 2 1 Caspase recruitment domain CoaE PF01121.20 PIK40587.1 - 0.0083 15.8 0.0 0.036 13.8 0.0 2.0 2 1 0 2 2 2 1 Dephospho-CoA kinase AAA_19 PF13245.6 PIK40587.1 - 0.013 15.8 0.0 0.061 13.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK40587.1 - 0.031 14.2 1.0 0.38 10.7 0.0 2.7 2 1 0 2 2 2 0 NACHT domain SWI2_SNF2 PF18766.1 PIK40587.1 - 0.032 13.9 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 PIK40587.1 - 0.06 13.6 0.4 0.38 11.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 PIK40587.1 - 0.087 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 PIK40587.1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein zf_Hakai PF18408.1 PIK40588.1 - 6.1e-18 64.2 2.8 6.1e-18 64.2 2.8 2.4 2 0 0 2 2 2 1 C2H2 Hakai zinc finger domain zf-C3HC4_3 PF13920.6 PIK40588.1 - 0.0081 16.0 8.9 0.024 14.5 8.9 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK40588.1 - 0.025 14.6 4.8 0.086 12.9 4.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK40588.1 - 0.029 14.3 1.8 0.029 14.3 1.8 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 PIK40588.1 - 0.066 13.1 9.5 0.28 11.1 9.6 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK40588.1 - 0.082 12.9 8.7 0.21 11.6 8.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain DZR PF12773.7 PIK40588.1 - 0.12 12.4 4.6 0.31 11.1 4.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4 PF00097.25 PIK40588.1 - 0.21 11.5 9.9 0.63 10.0 9.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK40588.1 - 0.61 10.3 5.9 0.43 10.8 1.0 2.5 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK40588.1 - 0.79 10.1 9.1 2.6 8.5 9.1 1.9 1 0 0 1 1 1 0 Ring finger domain Oxysterol_BP PF01237.18 PIK40589.1 - 6.1e-89 298.5 4.3 6.9e-87 291.7 4.3 2.4 1 1 0 1 1 1 1 Oxysterol-binding protein 7tm_1 PF00001.21 PIK40590.1 - 9.6e-60 202.1 15.9 1.2e-59 201.8 15.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK40590.1 - 1.5e-09 37.7 28.4 1.3e-08 34.5 16.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK40590.1 - 0.00018 21.2 23.1 0.00018 21.2 23.1 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ammonium_transp PF00909.21 PIK40591.1 - 1.4e-85 287.5 29.1 1.9e-85 287.0 29.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family HAMP PF00672.25 PIK40591.1 - 7.4e-05 23.0 0.0 22 5.5 0.0 4.6 5 0 0 5 5 5 2 HAMP domain Stomagen PF16851.5 PIK40591.1 - 0.057 13.4 0.4 31 4.7 0.1 3.3 2 1 1 3 3 3 0 Stomagen CPSase_C PF18302.1 PIK40591.1 - 0.71 10.5 3.0 3.2e+02 2.5 0.1 4.0 3 0 0 3 3 3 0 Carbamoyl phosphate synthetase C-terminal domain SIR2 PF02146.17 PIK40592.1 - 1.7e-55 187.7 0.0 2.8e-55 187.0 0.0 1.4 1 0 0 1 1 1 1 Sir2 family CNDH2_C PF16858.5 PIK40593.1 - 2.7e-55 188.3 0.0 4.3e-55 187.7 0.0 1.3 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 PIK40593.1 - 3.3e-44 149.7 0.5 9.7e-44 148.2 0.1 2.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal rve PF00665.26 PIK40595.1 - 5.9e-15 55.5 0.0 1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK40595.1 - 5e-05 23.0 0.0 0.0001 22.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DCX PF03607.17 PIK40598.1 - 7.7e-38 128.4 0.1 4.7e-19 68.3 0.0 2.4 2 0 0 2 2 2 2 Doublecortin TMEM132D_N PF15705.5 PIK40598.1 - 0.023 14.6 0.1 0.076 12.9 0.0 1.8 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term VPS13_C PF16909.5 PIK40599.1 - 7.4e-26 91.0 0.1 7.4e-26 91.0 0.1 2.7 3 0 0 3 3 3 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 PIK40599.1 - 7.2e-11 42.0 0.5 0.0019 17.6 0.0 4.8 3 1 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 PIK40599.1 - 7.7e-05 23.0 0.1 0.00024 21.4 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 PIK40600.1 - 9.4e-25 87.0 0.1 5.5e-24 84.5 0.1 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 PIK40600.1 - 2.7e-05 24.1 1.0 0.0003 20.6 0.8 2.8 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal SPRY PF00622.28 PIK40600.1 - 0.093 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 SPRY domain Acyl_transf_3 PF01757.22 PIK40601.1 - 3.4e-09 36.2 46.1 1.8e-07 30.6 34.4 3.3 3 1 0 3 3 3 2 Acyltransferase family Colipase-like PF15083.6 PIK40601.1 - 1.1 9.4 18.0 0.85 9.8 14.8 2.2 2 0 0 2 2 2 0 Colipase-like Hydrolase_4 PF12146.8 PIK40602.1 - 0.00031 20.1 0.0 0.00053 19.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK40602.1 - 0.0066 16.1 0.0 0.016 14.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK40602.1 - 0.0076 16.9 0.0 0.0097 16.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 PIK40602.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.4 2 0 0 2 2 2 0 Palmitoyl protein thioesterase RCC1 PF00415.18 PIK40603.1 - 4.1e-57 190.6 19.4 6.9e-11 42.6 0.6 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK40603.1 - 4.2e-30 102.9 34.2 5e-09 35.7 1.1 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 PIK40603.1 - 0.18 12.1 2.9 6.3 7.1 0.0 4.1 4 1 0 4 4 4 0 Putative heavy-metal chelation Myosin_head PF00063.21 PIK40604.1 - 4.5e-64 216.9 4.2 6.7e-64 216.3 4.2 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) MH2 PF03166.14 PIK40604.1 - 2e-26 93.3 0.1 5.8e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 MH2 domain IRF-3 PF10401.9 PIK40604.1 - 0.0047 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Interferon-regulatory factor 3 PINIT PF14324.6 PIK40604.1 - 0.06 13.7 0.2 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 PINIT domain IQ PF00612.27 PIK40604.1 - 0.11 12.4 2.3 0.3 11.0 2.3 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif L51_S25_CI-B8 PF05047.16 PIK40605.1 - 8e-10 38.5 0.1 1.7e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CLCA PF08434.11 PIK40606.1 - 4.6e-14 52.4 0.1 6.8e-14 51.8 0.1 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel N terminal Med18 PF09637.10 PIK40607.1 - 0.0071 16.2 0.0 0.0088 15.9 0.0 1.1 1 0 0 1 1 1 1 Med18 protein Gag_p15 PF08723.10 PIK40609.1 - 0.43 10.8 2.7 4.4 7.5 0.0 3.2 1 1 3 4 4 4 0 Gag protein p15 HYR PF02494.16 PIK40610.1 - 2.6e-69 229.6 90.8 4.8e-11 42.8 4.5 10.4 10 0 0 10 10 10 9 HYR domain CLCA PF08434.11 PIK40610.1 - 7.3e-06 25.5 1.3 2.6e-05 23.7 1.3 2.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal DUF4418 PF14387.6 PIK40610.1 - 8.8e-05 22.7 20.6 8.8 6.6 0.2 7.4 5 2 3 8 8 8 4 Domain of unknown function (DUF4418) U5_2-snRNA_bdg PF10597.9 PIK40610.1 - 0.00016 21.8 0.0 78 3.3 0.0 6.0 6 0 0 6 6 6 0 U5-snRNA binding site 2 of PrP8 DUF1833 PF08875.11 PIK40610.1 - 0.00035 20.1 14.8 3.1 7.3 0.1 6.2 4 2 3 7 7 7 3 Domain of unknown function (DUF1833) Glyco_hydro_81 PF03639.13 PIK40610.1 - 0.038 13.1 0.0 0.094 11.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 81 N-terminal domain KDZ PF18758.1 PIK40612.1 - 2.2e-45 155.0 0.0 4.3e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase CxC1 PF18802.1 PIK40612.1 - 5.3e-11 42.6 0.7 5.3e-11 42.6 0.7 2.2 2 0 0 2 2 2 1 CxC1 like cysteine cluster associated with KDZ transposases CxC2 PF18803.1 PIK40612.1 - 1.6e-08 34.7 1.0 2.9e-08 33.8 0.1 2.0 2 0 0 2 2 2 1 CxC2 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK40612.1 - 0.032 14.1 0.1 0.032 14.1 0.1 2.5 3 0 0 3 3 3 0 CxC3 like cysteine cluster associated with KDZ transposases zf-Mss51 PF13824.6 PIK40612.1 - 0.13 12.3 3.8 0.49 10.5 3.8 2.0 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TMEM219 PF14940.6 PIK40615.1 - 0.0036 16.9 2.0 0.0052 16.4 2.0 1.1 1 0 0 1 1 1 1 Transmembrane 219 HTH_32 PF13565.6 PIK40615.1 - 0.033 14.8 0.1 0.065 13.9 0.1 1.5 1 0 0 1 1 1 0 Homeodomain-like domain rve PF00665.26 PIK40616.1 - 1e-22 80.6 0.0 1.9e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40616.1 - 4.4e-05 23.5 0.1 0.00011 22.2 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain gag_pre-integrs PF13976.6 PIK40616.1 - 0.0071 16.2 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain TPR_2 PF07719.17 PIK40617.1 - 1.7e-05 24.6 0.1 0.0018 18.3 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Paf67 PF10255.9 PIK40617.1 - 0.00072 18.7 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_12 PF13424.6 PIK40617.1 - 0.0083 16.4 0.9 7.6 6.9 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK40617.1 - 0.018 15.2 0.0 0.35 11.2 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Raffinose_syn PF05691.12 PIK40617.1 - 0.18 9.6 0.1 0.28 8.9 0.1 1.2 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 Hid1 PF12722.7 PIK40617.1 - 4.3 5.4 7.0 5.4 5.0 7.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NB-ARC PF00931.22 PIK40618.1 - 3e-06 26.6 0.0 0.00065 19.0 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_22 PF13401.6 PIK40618.1 - 2.7e-05 24.4 0.0 6e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK40618.1 - 9.2e-05 22.9 0.0 0.00037 20.9 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 PIK40618.1 - 0.003 17.5 0.0 0.0061 16.5 0.0 1.5 1 1 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 PIK40618.1 - 0.0053 16.0 0.0 0.0072 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 PIK40618.1 - 0.0059 17.0 0.0 0.014 15.9 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK40618.1 - 0.019 15.5 0.1 0.042 14.4 0.0 1.8 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 PIK40618.1 - 0.044 13.7 0.0 0.12 12.3 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 PIK40618.1 - 0.066 13.5 0.1 0.13 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 PIK40618.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 PIK40618.1 - 0.14 11.4 0.0 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin GcnA_N PF18229.1 PIK40618.1 - 0.19 11.8 0.0 0.6 10.2 0.0 1.8 2 0 0 2 2 2 0 N-acetyl-beta-D-glucosaminidase N-terminal domain Toxin_trans PF07952.12 PIK40619.1 - 2.9 6.9 8.7 0.52 9.4 3.2 2.3 1 1 2 3 3 3 0 Clostridium neurotoxin, Translocation domain Helicase_C PF00271.31 PIK40620.1 - 1.3e-13 51.2 0.0 2.7e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 PIK40620.1 - 1e-08 34.9 10.5 1e-08 34.9 10.5 1.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK40620.1 - 2.2e-08 33.8 13.8 4.9e-08 32.7 13.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK40620.1 - 2.6e-08 34.1 13.1 5.3e-08 33.1 13.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK40620.1 - 3.2e-08 33.3 14.2 5.9e-08 32.5 14.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK40620.1 - 5.6e-07 29.6 14.0 1e-06 28.8 14.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 PIK40620.1 - 1e-05 25.7 6.4 4.6e-05 23.6 6.7 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK40620.1 - 1.5e-05 24.9 9.1 6.4e-05 22.9 9.5 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 PIK40620.1 - 1.7e-05 24.8 2.9 3.5e-05 23.8 2.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 PIK40620.1 - 2.6e-05 24.0 11.2 5.8e-05 22.9 11.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK40620.1 - 0.00053 19.9 12.0 0.00053 19.9 12.0 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.8 PIK40620.1 - 0.0023 17.7 6.3 0.0045 16.8 6.3 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 PIK40620.1 - 0.07 13.0 7.2 0.2 11.5 7.2 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF1644 PF07800.12 PIK40620.1 - 0.29 11.2 0.1 0.29 11.2 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1644) zf-RING_11 PF17123.5 PIK40620.1 - 0.58 10.0 13.6 1.3 8.8 13.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 PIK40620.1 - 0.93 9.3 8.5 2.5 8.0 8.5 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain adh_short PF00106.25 PIK40621.1 - 1.2e-22 80.3 0.4 1.5e-22 80.0 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40621.1 - 1.3e-14 54.4 0.0 1.6e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK40621.1 - 1.3e-06 28.5 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK40621.1 - 0.00011 21.7 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK40621.1 - 0.00022 20.7 0.2 0.00053 19.5 0.2 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase TFIIF_beta PF02270.15 PIK40623.1 - 6.6e-26 90.2 1.1 1.5e-25 89.1 1.1 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 PIK40623.1 - 4.8e-14 53.2 1.1 3.8e-12 47.1 0.0 2.5 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus Sin_N PF04801.13 PIK40623.1 - 0.01 15.1 0.1 0.025 13.8 0.0 1.6 1 1 0 1 1 1 0 Sin-like protein conserved region PAS PF00989.25 PIK40626.1 - 2.7e-12 46.7 0.0 3.4e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 PIK40626.1 - 4.4e-05 23.6 0.1 0.0002 21.5 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 PIK40626.1 - 0.00067 19.9 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 PIK40626.1 - 0.0033 17.7 0.0 0.0058 16.9 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 PIK40626.1 - 0.014 15.6 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 PAS fold PAS_3 PF08447.12 PIK40627.1 - 7.9e-07 29.3 0.0 1.8e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 PIK40627.1 - 2.1e-06 27.8 0.1 1.1e-05 25.5 0.0 2.2 2 0 0 2 2 2 1 PAS domain WD40 PF00400.32 PIK40628.1 - 1e-11 45.2 3.0 7.5e-05 23.4 0.1 2.5 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 PIK40629.1 - 3.2e-13 49.9 2.3 4.4e-07 30.5 0.2 4.5 4 1 0 4 4 4 2 WD domain, G-beta repeat TPR_11 PF13414.6 PIK40629.1 - 9.7e-08 31.6 0.4 1.8e-06 27.5 0.1 2.3 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 PIK40629.1 - 2.1e-07 31.4 0.2 0.019 15.4 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40629.1 - 8.6e-06 26.2 0.5 0.11 13.4 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40629.1 - 3.3e-05 23.5 1.2 0.17 11.7 0.0 3.5 2 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 PIK40629.1 - 5e-05 23.5 0.0 0.013 15.8 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 PIK40629.1 - 0.00098 19.1 3.4 0.36 11.0 0.0 4.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK40629.1 - 0.013 15.8 0.1 0.073 13.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK40629.1 - 0.052 13.8 0.1 1.2 9.5 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK40629.1 - 0.07 13.3 0.4 0.15 12.2 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.32 PIK40630.1 - 1.8e-09 38.0 3.7 2.5e-05 25.0 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40630.1 - 0.046 14.0 0.1 7.9 6.9 0.0 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CD45 PF12567.8 PIK40630.1 - 0.5 10.4 3.1 1.2 9.2 3.1 1.6 1 0 0 1 1 1 0 Leukocyte receptor CD45 Ephrin_rec_like PF07699.13 PIK40631.1 - 4.2e-16 58.4 30.1 1.1e-10 41.1 6.8 4.3 3 1 1 4 4 4 3 Putative ephrin-receptor like TSP_1 PF00090.19 PIK40631.1 - 8.3e-11 41.9 11.7 8.3e-11 41.9 11.7 4.5 5 2 1 6 6 6 1 Thrombospondin type 1 domain NCD3G PF07562.14 PIK40631.1 - 0.0014 18.6 13.0 0.008 16.1 1.2 5.6 3 1 2 6 6 6 5 Nine Cysteines Domain of family 3 GPCR Tyosinase_C PF18132.1 PIK40631.1 - 0.19 12.4 1.3 0.47 11.1 0.2 2.2 2 1 0 2 2 2 0 Tyosinase C-terminal domain Pkinase_Tyr PF07714.17 PIK40632.1 - 2.2e-16 59.9 0.0 3.3e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40632.1 - 1.2e-11 44.5 0.0 1.8e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK40632.1 - 0.0068 16.6 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK40632.1 - 0.039 14.1 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK40632.1 - 0.075 13.6 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Mito_carr PF00153.27 PIK40634.1 - 1.8e-13 50.2 0.0 1.4e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Spy1 PF11357.8 PIK40635.1 - 5.7e-60 201.3 1.9 7.8e-60 200.9 1.9 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein GCD14 PF08704.10 PIK40636.1 - 1.3e-16 61.0 0.0 3.3e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 PIK40636.1 - 3.4e-08 33.5 0.0 7.5e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 PIK40636.1 - 0.00076 20.1 0.0 0.002 18.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK40636.1 - 0.001 19.6 0.0 0.0026 18.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 PIK40636.1 - 0.0076 16.1 0.1 0.02 14.7 0.1 1.7 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_31 PF13847.6 PIK40636.1 - 0.0093 15.8 0.0 0.037 13.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 PIK40636.1 - 0.011 16.8 0.0 0.024 15.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK40636.1 - 0.032 14.0 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AAA_6 PF12774.7 PIK40637.1 - 6.8e-129 429.5 0.1 8.5e-126 419.3 0.0 4.5 4 1 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK40637.1 - 1.2e-115 386.8 13.7 1.2e-115 386.8 13.7 2.6 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 PIK40637.1 - 8.4e-113 377.9 4.1 2.7e-112 376.3 0.5 3.2 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 PIK40637.1 - 9.8e-50 169.3 1.6 4.7e-49 167.1 0.0 3.1 4 0 0 4 4 4 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 PIK40637.1 - 3.6e-31 108.0 0.0 7.9e-14 51.8 0.0 5.8 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK40637.1 - 2.6e-26 92.2 0.0 7.1e-19 68.0 0.0 5.6 6 0 0 6 6 5 2 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 PIK40637.1 - 3.1e-17 62.9 0.0 1e-16 61.2 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 PIK40637.1 - 5.8e-17 62.2 0.1 0.0072 16.6 0.0 6.8 6 0 0 6 6 5 4 AAA domain AAA_18 PF13238.6 PIK40637.1 - 7.4e-14 52.4 0.1 0.084 13.4 0.0 6.2 5 0 0 5 5 5 3 AAA domain AAA PF00004.29 PIK40637.1 - 2.2e-13 50.8 0.0 0.0043 17.5 0.0 5.0 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK40637.1 - 5.2e-13 49.7 0.0 0.36 11.2 0.0 6.5 6 0 0 6 6 5 3 AAA ATPase domain AAA_33 PF13671.6 PIK40637.1 - 1.2e-12 48.2 0.0 0.0056 16.8 0.0 5.3 5 0 0 5 5 5 3 AAA domain AAA_30 PF13604.6 PIK40637.1 - 5.3e-07 29.6 0.2 1.7 8.3 0.0 4.6 4 0 0 4 4 4 2 AAA domain ABC_tran PF00005.27 PIK40637.1 - 1.1e-06 29.2 0.1 0.26 11.8 0.0 4.8 4 0 0 4 4 3 2 ABC transporter AAA_29 PF13555.6 PIK40637.1 - 6.4e-06 25.8 0.1 0.5 10.2 0.0 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain T2SSE PF00437.20 PIK40637.1 - 1.5e-05 24.2 0.0 0.12 11.4 0.0 3.8 4 0 0 4 4 3 1 Type II/IV secretion system protein AAA_14 PF13173.6 PIK40637.1 - 1.7e-05 24.9 0.0 0.7 9.9 0.0 4.6 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 PIK40637.1 - 2.2e-05 24.8 0.2 4.5 7.7 0.0 6.2 6 0 0 6 6 6 1 RNA helicase Mg_chelatase PF01078.21 PIK40637.1 - 4.1e-05 23.1 4.7 0.45 9.9 0.0 4.3 5 0 0 5 5 3 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 PIK40637.1 - 4.9e-05 23.7 0.0 0.21 11.9 0.0 4.6 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 PIK40637.1 - 5.5e-05 23.0 0.1 10 5.7 0.0 4.9 4 0 0 4 4 4 0 AAA domain Rad17 PF03215.15 PIK40637.1 - 6.4e-05 23.0 0.0 3.9 7.3 0.0 4.5 4 0 0 4 4 4 1 Rad17 P-loop domain AAA_lid_1 PF17857.1 PIK40637.1 - 9.5e-05 22.6 0.0 0.0008 19.6 0.0 2.6 3 0 0 3 3 2 1 AAA+ lid domain FtsK_SpoIIIE PF01580.18 PIK40637.1 - 0.00015 21.2 0.0 2.2 7.6 0.0 3.7 3 0 0 3 3 3 2 FtsK/SpoIIIE family IstB_IS21 PF01695.17 PIK40637.1 - 0.00067 19.4 1.0 0.77 9.5 0.0 4.7 5 0 0 5 5 5 1 IstB-like ATP binding protein RsgA_GTPase PF03193.16 PIK40637.1 - 0.0013 18.6 0.0 12 5.7 0.0 3.7 3 0 0 3 3 3 0 RsgA GTPase NACHT PF05729.12 PIK40637.1 - 0.0041 17.1 1.6 34 4.3 0.0 5.0 5 0 0 5 5 4 0 NACHT domain TsaE PF02367.17 PIK40637.1 - 0.0076 16.2 1.5 5.3 7.1 0.0 4.3 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 PIK40637.1 - 0.0086 15.7 0.0 0.48 10.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 PIK40637.1 - 0.012 15.4 0.1 0.34 10.7 0.0 2.9 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AIPR PF10592.9 PIK40637.1 - 0.071 12.7 4.0 0.32 10.6 0.2 2.6 2 0 0 2 2 2 0 AIPR protein AAA_11 PF13086.6 PIK40637.1 - 0.09 12.5 0.3 5 6.8 0.0 3.6 3 1 0 3 3 3 0 AAA domain SRP54 PF00448.22 PIK40637.1 - 0.43 10.2 2.3 41 3.7 0.1 3.8 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain ARL2_Bind_BART PF11527.8 PIK40637.1 - 2.9 8.0 6.8 48 4.1 0.0 4.5 4 1 1 5 5 5 0 The ARF-like 2 binding protein BART AAA_23 PF13476.6 PIK40637.1 - 2.9 8.3 16.5 26 5.3 0.0 6.4 6 1 1 7 7 5 0 AAA domain UAA PF08449.11 PIK40638.1 - 4.5e-69 233.0 24.1 6.5e-69 232.4 24.1 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 PIK40638.1 - 3.9e-05 23.8 32.8 0.0043 17.2 17.0 3.6 3 1 1 4 4 4 2 EamA-like transporter family TB2_DP1_HVA22 PF03134.19 PIK40638.1 - 0.021 14.7 0.7 0.021 14.7 0.7 3.1 3 1 1 4 4 4 0 TB2/DP1, HVA22 family NDUF_B6 PF09782.9 PIK40638.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit PgaD PF13994.6 PIK40638.1 - 6 6.9 6.8 5.8 7.0 0.2 3.3 3 1 0 4 4 4 0 PgaD-like protein Calx-beta PF03160.14 PIK40641.1 - 3.9e-09 36.6 0.1 3.9e-09 36.6 0.1 1.7 3 0 0 3 3 3 1 Calx-beta domain UL45 PF05473.12 PIK40641.1 - 0.0043 16.7 0.2 0.0061 16.2 0.2 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK40641.1 - 0.024 15.3 0.4 0.04 14.6 0.4 1.4 1 0 0 1 1 1 0 Lectin C-type domain Chordopox_A33R PF05966.12 PIK40641.1 - 0.081 12.2 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein p450 PF00067.22 PIK40642.1 - 3.9e-85 286.3 0.6 8.6e-85 285.2 0.6 1.4 1 1 0 1 1 1 1 Cytochrome P450 BCS1_N PF08740.11 PIK40642.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 BCS1 N terminal SANTA PF09133.10 PIK40643.1 - 1.4e-20 73.6 0.0 4.8e-20 71.8 0.0 1.9 1 0 0 1 1 1 1 SANTA (SANT Associated) Myb_DNA-binding PF00249.31 PIK40643.1 - 0.0021 18.2 0.6 0.0021 18.2 0.6 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain TAF PF02969.17 PIK40644.1 - 2.6e-17 62.7 0.0 4.9e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 PIK40644.1 - 8.2e-17 61.3 0.0 2e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain JHY PF15261.6 PIK40645.1 - 1.4e-20 74.3 6.4 2.5e-20 73.5 6.4 1.4 1 0 0 1 1 1 1 Jhy protein MRP-L27 PF09809.9 PIK40647.1 - 2.2e-21 75.8 0.0 2.7e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Pkinase PF00069.25 PIK40649.1 - 8.6e-53 179.4 1.5 1e-52 179.1 1.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40649.1 - 2.1e-35 122.3 0.4 2.4e-35 122.1 0.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK40649.1 - 4.6e-06 25.8 0.6 7.1e-06 25.2 0.6 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK40649.1 - 0.0004 19.8 1.7 0.0007 19.0 1.7 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 PIK40649.1 - 0.0011 18.6 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.6 PIK40649.1 - 0.011 15.1 0.0 0.021 14.2 0.0 1.3 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 PIK40649.1 - 0.039 13.5 1.8 0.091 12.3 1.8 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase ZU5 PF00791.20 PIK40650.1 - 2.1e-15 56.8 0.0 4.4e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain NACHT PF05729.12 PIK40651.1 - 1.2e-13 51.3 0.0 2.4e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK40651.1 - 3.3e-05 23.6 0.0 0.00015 21.4 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 PIK40651.1 - 0.00048 20.5 0.1 0.0013 19.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK40651.1 - 0.02 14.9 0.4 0.32 11.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain DAP3 PF10236.9 PIK40651.1 - 0.021 14.0 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATPase PF06745.13 PIK40651.1 - 0.069 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 PIK40651.1 - 0.076 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 PIK40651.1 - 0.087 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 PIK40651.1 - 0.089 12.2 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 PIK40651.1 - 0.094 12.1 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 PIK40651.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Death PF00531.22 PIK40652.1 - 2.8e-12 46.6 1.0 6.3e-12 45.5 1.0 1.7 1 0 0 1 1 1 1 Death domain NACHT PF05729.12 PIK40653.1 - 5.8e-10 39.3 0.0 9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK40653.1 - 2.6e-05 23.9 0.0 6e-05 22.7 0.0 1.6 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 PIK40653.1 - 0.0024 17.2 0.1 0.1 12.0 0.0 2.3 2 0 0 2 2 2 1 KaiC AAA PF00004.29 PIK40653.1 - 0.015 15.7 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK40653.1 - 0.016 15.2 0.3 0.06 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 PIK40653.1 - 0.021 14.0 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 PIK40653.1 - 0.056 12.7 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 PIK40653.1 - 0.063 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 PIK40653.1 - 0.064 12.5 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 PIK40653.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TrmB PF01978.19 PIK40653.1 - 0.12 12.2 0.4 0.31 11.0 0.1 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB IstB_IS21 PF01695.17 PIK40653.1 - 0.12 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DED PF01335.21 PIK40654.1 - 5.5e-06 26.6 0.5 0.022 15.0 0.1 2.3 2 0 0 2 2 2 2 Death effector domain BORA_N PF15280.6 PIK40654.1 - 0.076 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein aurora borealis N-terminus Acetyltransf_1 PF00583.25 PIK40655.1 - 0.0033 17.7 0.0 0.0041 17.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK40655.1 - 0.014 15.8 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TauD PF02668.16 PIK40656.1 - 3.4e-35 122.1 0.2 4.6e-35 121.7 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK40656.1 - 2.1e-07 31.5 0.1 5.7e-06 26.9 0.1 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 PIK40656.1 - 0.041 13.0 0.1 0.08 12.0 0.1 1.5 1 1 0 1 1 1 0 CsiD Glyco_transf_29 PF00777.18 PIK40657.1 - 1.4e-58 198.4 0.1 1.8e-58 198.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK40658.1 - 2.8e-54 184.3 0.0 3.5e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 4HBT_3 PF13622.6 PIK40659.1 - 2.6e-57 194.9 0.0 3.4e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 PIK40659.1 - 6e-29 100.6 0.0 1.4e-19 70.2 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase Kdo PF06293.14 PIK40660.1 - 4.8e-15 55.5 0.1 8e-15 54.8 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 PIK40660.1 - 3.2e-11 43.1 0.1 4.2e-11 42.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 PIK40660.1 - 4.8e-11 43.0 0.0 0.0001 22.3 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 PIK40660.1 - 2.9e-10 40.0 0.0 4.8e-10 39.3 0.0 1.3 1 1 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 PIK40660.1 - 1.9e-07 30.7 0.0 2.4e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 PIK40660.1 - 5.8e-05 22.5 0.1 8.7e-05 22.0 0.1 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 PIK40660.1 - 0.0022 16.9 0.0 0.0028 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Amino_oxidase PF01593.24 PIK40661.1 - 5.5e-10 39.1 0.0 6.1e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Ion_trans PF00520.31 PIK40662.1 - 0.016 14.4 0.1 0.017 14.4 0.1 1.0 1 0 0 1 1 1 0 Ion transport protein COG5 PF10392.9 PIK40663.1 - 0.0046 17.1 0.3 0.0081 16.3 0.3 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 MbeD_MobD PF04899.12 PIK40663.1 - 0.058 13.5 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 MbeD/MobD like FlaC_arch PF05377.11 PIK40663.1 - 0.14 12.6 1.0 0.28 11.6 1.0 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 PIK40663.1 - 0.61 10.1 2.5 0.48 10.4 0.2 1.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Il2rg PF15874.5 PIK40664.1 - 1e-16 61.0 0.0 1.7e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain Thioredoxin_9 PF14595.6 PIK40664.1 - 0.1 12.4 0.0 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin zf-H2C2_2 PF13465.6 PIK40665.1 - 9.5e-08 32.1 1.2 9.5e-08 32.1 1.2 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK40665.1 - 9.8e-06 25.8 10.9 2.5e-05 24.5 3.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK40665.1 - 0.00028 21.4 2.3 0.00028 21.4 2.3 4.5 4 0 0 4 4 4 2 C2H2-type zinc finger Actin_micro PF17003.5 PIK40665.1 - 0.12 11.5 0.2 0.16 11.1 0.2 1.1 1 0 0 1 1 1 0 Putative actin-like family MMS1_N PF10433.9 PIK40666.1 - 0.013 14.1 0.0 0.018 13.7 0.0 1.2 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term BBS2_N PF14781.6 PIK40666.1 - 0.16 11.9 0.1 24 4.9 0.0 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal SNARE PF05739.19 PIK40667.1 - 0.00052 20.0 1.0 0.0011 19.0 0.1 2.0 2 0 0 2 2 2 1 SNARE domain Acyl_transf_1 PF00698.21 PIK40669.1 - 2.7e-11 43.6 0.0 4.4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain FH2 PF02181.23 PIK40670.1 - 9.8e-46 156.6 18.1 8.1e-44 150.2 4.5 4.3 3 1 1 4 4 4 2 Formin Homology 2 Domain WH2 PF02205.20 PIK40670.1 - 0.00013 21.6 0.1 0.01 15.6 0.0 2.8 2 0 0 2 2 2 1 WH2 motif DUF1948 PF09185.10 PIK40670.1 - 0.39 10.6 3.1 1.1 9.1 2.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1948) SPOUT_MTase PF02590.17 PIK40672.1 - 0.2 11.7 0.7 0.79 9.7 0.5 2.2 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase adh_short PF00106.25 PIK40673.1 - 1.6e-40 138.7 0.7 2.3e-40 138.1 0.4 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40673.1 - 1.7e-28 99.8 0.5 3.9e-28 98.6 0.4 1.7 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK40673.1 - 3.6e-09 36.8 0.1 6.7e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK40673.1 - 3.6e-05 23.4 0.1 4.6e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK40673.1 - 6.7e-05 22.0 0.2 9.5e-05 21.5 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 PIK40673.1 - 0.00013 21.3 0.0 0.00016 20.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK40673.1 - 0.0027 17.1 0.1 0.0035 16.8 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF2683 PF10884.8 PIK40673.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) adh_short PF00106.25 PIK40674.1 - 3.1e-28 98.6 1.6 1.5e-27 96.4 1.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40674.1 - 8.2e-18 64.8 0.6 1.6e-16 60.6 0.6 2.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 PIK40674.1 - 0.00084 18.9 0.3 0.0016 17.9 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 PIK40674.1 - 0.00095 19.1 2.3 0.0012 18.8 0.2 2.2 2 1 0 2 2 2 1 KR domain DUF735 PF05246.11 PIK40674.1 - 0.0023 17.9 0.5 0.0035 17.3 0.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF735) RhoGAP PF00620.27 PIK40675.1 - 1.1e-19 70.8 0.0 2.1e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 PIK40675.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK40676.1 - 1.6e-06 27.8 0.0 2.5e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family adh_short PF00106.25 PIK40678.1 - 1.6e-35 122.4 1.0 7.9e-28 97.3 0.4 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40678.1 - 3.7e-29 101.9 0.5 1.7e-27 96.5 0.3 2.2 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK40678.1 - 5.3e-07 29.7 4.6 0.0034 17.3 0.1 2.6 3 1 0 3 3 3 2 KR domain Epimerase PF01370.21 PIK40678.1 - 0.053 13.0 0.4 5.9 6.3 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 PIK40679.1 - 1e-29 103.4 2.6 5.2e-28 97.8 1.4 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40679.1 - 8.8e-25 87.6 2.5 8.1e-23 81.2 0.5 2.8 1 1 2 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK40679.1 - 4.7e-09 36.4 0.1 9.1e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 PIK40679.1 - 3.3e-05 23.5 0.1 6.8e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK40679.1 - 4.4e-05 23.1 0.1 5.7e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK40679.1 - 4.7e-05 22.7 0.2 9.7e-05 21.6 0.1 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 PIK40679.1 - 0.066 12.8 0.1 0.13 11.8 0.1 1.5 1 1 0 1 1 1 0 NmrA-like family adh_short PF00106.25 PIK40680.1 - 3.6e-35 121.2 2.1 4.5e-35 120.9 2.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK40680.1 - 1.4e-28 100.1 1.7 2.4e-28 99.3 1.7 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK40680.1 - 1.1e-08 35.2 0.2 1.7e-08 34.6 0.2 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK40680.1 - 2.5e-05 23.9 0.2 3.1e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK40680.1 - 5e-05 22.6 0.1 9.1e-05 21.7 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK40680.1 - 5.5e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 PIK40680.1 - 0.00061 18.9 0.3 0.00078 18.5 0.3 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 PIK40680.1 - 0.039 14.2 1.1 0.21 11.8 0.2 2.2 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain LppC PF04348.13 PIK40680.1 - 0.069 11.9 0.0 0.069 11.9 0.0 1.1 1 0 0 1 1 1 0 LppC putative lipoprotein TPR_19 PF14559.6 PIK40683.1 - 4.9e-10 39.8 3.9 0.091 13.3 0.0 6.2 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK40683.1 - 2.6e-06 27.1 13.6 0.86 9.9 0.3 7.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK40683.1 - 2.6e-05 24.3 1.5 24 5.6 0.0 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK40683.1 - 6e-05 23.4 6.2 15 6.5 0.2 8.1 10 2 1 11 11 10 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40683.1 - 9.1e-05 23.0 3.6 56 4.9 0.1 7.1 6 2 2 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40683.1 - 0.00032 20.4 10.2 0.16 11.9 0.1 6.7 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK40683.1 - 0.00061 20.0 3.7 17 5.8 0.0 5.6 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK40683.1 - 0.00093 19.8 0.3 43 4.9 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK40683.1 - 0.0014 18.2 2.0 4.5 7.1 0.0 5.7 7 0 0 7 7 7 1 TPR repeat TPR_8 PF13181.6 PIK40683.1 - 0.0033 17.5 13.8 4.9 7.6 0.1 7.6 9 0 0 9 9 9 1 Tetratricopeptide repeat DUF2225 PF09986.9 PIK40683.1 - 0.049 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) ASC PF00858.24 PIK40684.1 - 6.7e-36 124.2 3.0 8.3e-36 123.9 3.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Wzz PF02706.15 PIK40684.1 - 0.059 13.7 0.2 0.1 12.9 0.2 1.4 1 0 0 1 1 1 0 Chain length determinant protein Fibrinogen_C PF00147.18 PIK40685.1 - 6.2e-64 215.8 8.5 7e-64 215.6 8.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK40687.1 - 1.8e-26 93.0 0.0 2.3e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK40688.1 - 3.5e-06 26.7 0.0 1.2e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK40689.1 - 1.8e-10 40.7 0.2 2.7e-10 40.1 0.2 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK40690.1 - 3.3e-33 115.1 0.0 3.9e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SET PF00856.28 PIK40693.1 - 6.4e-09 36.4 0.1 8.6e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 SET domain AvrD PF05655.11 PIK40694.1 - 0.00089 18.7 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Pseudomonas avirulence D protein (AvrD) Gly_radical PF01228.21 PIK40695.1 - 0.11 13.0 0.0 0.43 11.1 0.0 2.0 1 0 0 1 1 1 0 Glycine radical RNase_H PF00075.24 PIK40697.1 - 0.053 13.7 0.1 0.089 13.0 0.1 1.4 1 0 0 1 1 1 0 RNase H IRF-2BP1_2 PF11261.8 PIK40698.1 - 0.28 10.8 1.3 0.94 9.1 0.3 2.1 2 0 0 2 2 2 0 Interferon regulatory factor 2-binding protein zinc finger zf-RING_5 PF14634.6 PIK40698.1 - 0.55 10.2 4.0 0.2 11.7 0.8 2.0 2 0 0 2 2 2 0 zinc-RING finger domain Exo_endo_phos PF03372.23 PIK40703.1 - 0.0011 18.5 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RET_CLD3 PF17812.1 PIK40704.1 - 0.16 12.2 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 RET Cadherin like domain 3 zf-CCHC PF00098.23 PIK40705.1 - 2.1e-07 30.7 15.8 0.00051 20.0 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK40705.1 - 0.00039 20.2 8.1 0.078 12.8 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK40705.1 - 0.0026 17.7 12.7 0.2 11.6 1.3 3.4 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK40705.1 - 0.017 14.9 0.2 0.017 14.9 0.2 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK40705.1 - 0.017 14.8 0.8 0.017 14.8 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK40705.1 - 0.018 14.7 11.1 3.8 7.3 0.3 3.3 2 1 1 3 3 3 0 Zinc knuckle DUF3127 PF11325.8 PIK40706.1 - 0.0028 17.9 0.1 0.0058 16.8 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3127) zf-CCHC PF00098.23 PIK40707.1 - 0.01 15.9 0.2 0.018 15.1 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle CENP-B_N PF04218.13 PIK40708.1 - 1.8e-07 30.6 4.6 17 5.1 0.0 8.4 3 3 6 9 9 9 1 CENP-B N-terminal DNA-binding domain Hormone_6 PF00236.18 PIK40708.1 - 0.0096 15.9 13.9 4.8 7.2 0.1 3.8 1 1 1 3 3 3 3 Glycoprotein hormone Cupin_1 PF00190.22 PIK40708.1 - 0.05 13.2 0.3 31 4.1 0.0 3.4 1 1 3 5 5 5 0 Cupin Myf5 PF12232.8 PIK40708.1 - 0.26 12.1 35.9 53 4.7 1.7 9.0 2 1 6 9 9 9 0 Myogenic determination factor 5 PLAC8 PF04749.17 PIK40708.1 - 0.76 10.8 7.2 1.5e+02 3.4 7.2 3.9 1 1 0 1 1 1 0 PLAC8 family Endomucin PF07010.12 PIK40709.1 - 0.00015 21.8 29.7 0.00021 21.4 29.7 1.1 1 0 0 1 1 1 1 Endomucin TMEM154 PF15102.6 PIK40709.1 - 0.041 13.8 0.0 0.041 13.8 0.0 2.9 1 1 1 2 2 2 0 TMEM154 protein family Ndc1_Nup PF09531.10 PIK40709.1 - 0.099 11.3 5.8 0.1 11.3 5.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 PIK40709.1 - 0.43 9.7 14.6 0.64 9.1 14.6 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein ELM2 PF01448.24 PIK40710.1 - 9.6e-07 29.5 0.0 2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.31 PIK40711.1 - 4.7e-11 42.7 1.3 5.1e-09 36.2 0.0 2.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain GATA PF00320.27 PIK40711.1 - 0.002 17.7 3.1 0.0067 16.0 3.1 2.0 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-bind_6 PF13921.6 PIK40711.1 - 0.012 15.8 0.2 0.037 14.3 0.0 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain PTS_2-RNA PF01885.16 PIK40712.1 - 7.9e-61 205.3 0.0 9.6e-61 205.0 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Nup96 PF12110.8 PIK40713.1 - 0.046 12.8 0.4 0.074 12.2 0.4 1.2 1 1 0 1 1 1 0 Nuclear protein 96 RAP PF08373.10 PIK40714.1 - 0.026 14.6 1.6 0.043 13.9 0.3 2.0 2 0 0 2 2 2 0 RAP domain NCU-G1 PF15065.6 PIK40714.1 - 0.072 12.1 0.7 0.1 11.6 0.6 1.3 1 1 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Asparaginase_2 PF01112.18 PIK40715.1 - 4.7e-109 364.1 7.6 5.5e-109 363.9 7.6 1.0 1 0 0 1 1 1 1 Asparaginase DSPc PF00782.20 PIK40718.1 - 1.8e-19 69.9 0.1 1.8e-19 69.8 0.1 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK40718.1 - 0.0017 18.0 0.0 0.0017 18.0 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK40718.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.0 1 0 0 1 1 1 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 PIK40718.1 - 0.042 14.2 0.0 0.043 14.1 0.0 1.1 1 0 0 1 1 1 0 Rit1 DUSP-like domain fn3 PF00041.21 PIK40719.1 - 1.5e-08 34.9 0.1 0.00016 22.0 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Fibrinogen_C PF00147.18 PIK40720.1 - 5.2e-33 114.7 0.1 6.5e-33 114.4 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK40720.1 - 0.0061 16.5 2.1 0.0061 16.5 2.1 2.8 2 1 1 3 3 3 1 TILa domain Fibrinogen_C PF00147.18 PIK40721.1 - 1.4e-36 126.4 1.0 2.1e-36 125.8 1.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK40721.1 - 2.4e-05 24.4 3.5 2.4e-05 24.4 3.5 2.0 2 0 0 2 2 2 1 EGF domain TILa PF12714.7 PIK40721.1 - 8.7e-05 22.4 5.0 0.0001 22.2 0.9 2.8 3 0 0 3 3 3 1 TILa domain uDENN PF03456.18 PIK40724.1 - 1e-19 71.0 1.2 2.4e-19 69.8 1.2 1.7 1 0 0 1 1 1 1 uDENN domain DENN PF02141.21 PIK40724.1 - 2.2e-13 50.6 0.1 6.6e-13 49.0 0.1 1.7 1 1 0 1 1 1 1 DENN (AEX-3) domain TPR_1 PF00515.28 PIK40725.1 - 2.6e-12 46.0 0.0 6.6e-05 22.6 0.0 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK40725.1 - 1.4e-11 43.5 0.0 0.00054 19.9 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK40725.1 - 7.3e-09 35.0 0.0 0.0012 18.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK40725.1 - 3e-08 33.8 0.3 0.011 16.5 0.0 5.3 2 2 4 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK40725.1 - 2.6e-07 30.2 0.0 1.6 8.5 0.0 4.7 3 2 1 4 4 4 3 TPR repeat TPR_8 PF13181.6 PIK40725.1 - 2e-06 27.5 0.0 0.007 16.5 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK40725.1 - 4.3e-06 26.9 0.0 0.0005 20.3 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK40725.1 - 7.5e-06 26.5 0.0 0.075 13.7 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK40725.1 - 0.00011 22.3 0.2 4.7 7.8 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK40725.1 - 0.014 15.9 0.0 2.7 8.6 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK40725.1 - 0.026 14.6 0.0 20 5.4 0.0 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK40725.1 - 0.062 13.2 0.1 1.2 9.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 PIK40725.1 - 0.18 11.9 0.1 38 4.5 0.0 3.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain NYD-SP28 PF14772.6 PIK40726.1 - 1.7e-28 98.6 14.1 1.7e-28 98.6 14.1 4.4 3 1 2 5 5 5 1 Sperm tail NYD-SP28_assoc PF14775.6 PIK40726.1 - 7.8e-07 29.1 3.4 7.8e-07 29.1 3.4 3.1 2 0 0 2 2 2 1 Sperm tail C-terminal domain DHH PF01368.20 PIK40726.1 - 0.061 13.6 0.1 0.17 12.1 0.1 1.8 1 0 0 1 1 1 0 DHH family WD40 PF00400.32 PIK40727.1 - 5.5e-16 58.7 6.8 0.055 14.4 0.0 8.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40727.1 - 0.00011 22.5 0.0 0.00086 19.6 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3140 PF11338.8 PIK40727.1 - 0.74 10.3 3.1 4.6 7.8 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) UPF0154 PF03672.13 PIK40728.1 - 0.0038 17.2 0.0 0.0064 16.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) DUF3349 PF11829.8 PIK40728.1 - 0.043 14.6 0.0 16 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) Myb_DNA-bind_4 PF13837.6 PIK40730.1 - 1.3e-15 57.5 0.4 2.3e-15 56.8 0.4 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain I-set PF07679.16 PIK40730.1 - 2.4e-13 50.0 0.0 4.5e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40730.1 - 1e-12 48.4 0.0 2.8e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK40730.1 - 6.7e-08 32.6 0.2 1.4e-06 28.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40730.1 - 3.9e-07 30.3 0.0 9e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain MADF_DNA_bdg PF10545.9 PIK40730.1 - 0.0021 18.4 0.4 0.0039 17.5 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_3 PF12776.7 PIK40730.1 - 0.03 15.3 0.1 0.056 14.4 0.1 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain V-set PF07686.17 PIK40730.1 - 0.079 13.1 0.0 0.55 10.4 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin V-set domain Lantibiotic_a PF14867.6 PIK40730.1 - 0.32 10.8 0.1 0.32 10.8 0.1 2.0 2 0 0 2 2 2 0 Lantibiotic alpha DDE_Tnp_4 PF13359.6 PIK40731.1 - 1.3e-37 128.9 0.0 2.8e-37 127.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK40731.1 - 1.6e-15 57.3 0.0 2.4e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 PIK40731.1 - 1.3e-08 34.8 4.3 1.4e-07 31.4 0.4 3.0 2 1 0 2 2 2 1 Transposase DDE domain HTH_Tnp_4 PF13613.6 PIK40731.1 - 5.7e-05 22.8 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease S_4TM PF18159.1 PIK40731.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Pkinase_Tyr PF07714.17 PIK40732.1 - 1.3e-88 296.6 0.0 2.3e-88 295.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40732.1 - 3.6e-38 131.5 0.0 6e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 PIK40732.1 - 6.2e-21 74.5 3.7 1.7e-20 73.1 3.7 1.9 1 0 0 1 1 1 1 Kringle domain I-set PF07679.16 PIK40732.1 - 4e-12 46.0 0.0 7.4e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40732.1 - 1.4e-10 41.6 0.0 2.9e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Fz PF01392.22 PIK40732.1 - 2.2e-09 37.9 3.6 7.3e-09 36.2 3.6 1.9 1 0 0 1 1 1 1 Fz domain ig PF00047.25 PIK40732.1 - 1.7e-07 31.3 0.1 3.5e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK40732.1 - 9.7e-07 29.0 0.0 2.2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK40732.1 - 0.0007 19.8 0.1 0.0052 16.9 0.1 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK40732.1 - 0.028 14.8 0.0 0.061 13.7 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Haspin_kinase PF12330.8 PIK40732.1 - 0.16 10.9 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Y_phosphatase PF00102.27 PIK40733.1 - 1.9e-103 345.1 3.5 1.2e-72 244.3 4.7 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK40733.1 - 6.8e-07 29.6 0.2 0.014 15.7 0.0 3.6 3 0 0 3 3 3 2 Fibronectin type III domain PTPlike_phytase PF14566.6 PIK40733.1 - 4.3e-06 26.9 4.6 0.0029 17.7 0.0 4.6 5 0 0 5 5 5 1 Inositol hexakisphosphate DSPc PF00782.20 PIK40733.1 - 0.00014 21.6 0.0 0.00073 19.4 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK40733.1 - 0.00026 21.0 0.5 0.0029 17.6 0.1 2.5 2 1 0 2 2 2 1 Tyrosine phosphatase family Pur_ac_phosph_N PF16656.5 PIK40733.1 - 0.0063 17.1 1.1 6.9 7.3 0.0 3.8 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain vWF_A PF12450.8 PIK40733.1 - 0.021 14.8 0.3 0.17 11.8 0.0 2.6 3 0 0 3 3 3 0 von Willebrand factor Oxidored_q2 PF00420.24 PIK40733.1 - 0.097 12.3 0.1 0.23 11.1 0.1 1.6 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Insulin_TMD PF17870.1 PIK40733.1 - 0.94 9.6 5.3 3.1 7.9 5.3 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment EGF_2 PF07974.13 PIK40734.1 - 0.00033 20.9 14.3 0.00033 20.9 14.3 6.0 5 2 0 5 5 5 1 EGF-like domain hEGF PF12661.7 PIK40734.1 - 0.0016 19.0 8.1 0.0016 19.0 8.1 6.8 6 1 2 8 8 8 2 Human growth factor-like EGF fn3 PF00041.21 PIK40735.1 - 1.5e-07 31.6 0.2 0.0011 19.2 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain EGF_2 PF07974.13 PIK40735.1 - 0.00082 19.7 14.4 0.00082 19.7 14.4 6.7 5 1 0 5 5 5 1 EGF-like domain hEGF PF12661.7 PIK40735.1 - 0.0018 18.8 7.9 0.0018 18.8 7.9 5.8 6 1 0 6 6 6 1 Human growth factor-like EGF Pur_ac_phosph_N PF16656.5 PIK40735.1 - 0.067 13.8 0.8 4.1 8.1 0.0 2.9 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Y_phosphatase PF00102.27 PIK40736.1 - 1.8e-45 155.3 0.2 3.3e-45 154.5 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Shisa PF13908.6 PIK40736.1 - 7.5e-06 26.3 0.3 1.4e-05 25.4 0.3 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK40736.1 - 0.00047 20.1 0.3 0.00095 19.1 0.3 1.5 1 0 0 1 1 1 1 TMEM154 protein family Y_phosphatase2 PF03162.13 PIK40736.1 - 0.00098 18.7 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family Orf78 PF06024.12 PIK40736.1 - 0.0026 18.0 0.4 0.0073 16.6 0.4 1.8 1 0 0 1 1 1 1 Orf78 (ac78) SID-1_RNA_chan PF13965.6 PIK40736.1 - 0.0029 16.1 0.6 0.0043 15.5 0.6 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 EphA2_TM PF14575.6 PIK40736.1 - 0.0043 17.9 0.3 0.021 15.7 0.3 2.1 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain PTP_tm PF18861.1 PIK40736.1 - 0.049 13.6 0.2 0.1 12.6 0.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF4330 PF14221.6 PIK40736.1 - 0.056 13.7 0.3 0.1 12.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) PTPLA PF04387.14 PIK40736.1 - 0.057 13.2 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA ODV-E18 PF10717.9 PIK40736.1 - 0.079 12.8 0.5 0.18 11.7 0.5 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Amnionless PF14828.6 PIK40736.1 - 0.083 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Amnionless 7TM_GPCR_Srx PF10328.9 PIK40736.1 - 0.086 12.5 2.6 0.14 11.8 2.6 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF3377 PF11857.8 PIK40736.1 - 0.095 12.6 0.4 0.29 11.1 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Cadherin_C_2 PF16492.5 PIK40736.1 - 0.096 13.4 1.6 0.18 12.6 0.2 2.2 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal ERGIC_N PF13850.6 PIK40736.1 - 0.11 12.9 1.3 0.18 12.2 0.5 1.8 2 0 0 2 2 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF4736 PF15883.5 PIK40736.1 - 0.11 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) DUF4834 PF16118.5 PIK40736.1 - 0.15 13.0 0.2 0.15 13.0 0.2 2.0 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) Peptidase_M56 PF05569.11 PIK40736.1 - 0.19 10.9 1.0 0.25 10.5 0.1 1.6 2 0 0 2 2 2 0 BlaR1 peptidase M56 Flp1_like PF16982.5 PIK40736.1 - 0.51 9.8 6.0 1.1 8.7 6.0 1.5 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain 7tm_2 PF00002.24 PIK40737.1 - 2.1e-32 112.4 23.2 3.3e-32 111.7 23.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Phage_int_SAM_1 PF02899.17 PIK40738.1 - 2.4e-05 24.5 0.1 5.9e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK40738.1 - 2.6e-05 24.6 0.0 4.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 PIK40739.1 - 2.9e-29 102.2 0.2 6.2e-29 101.1 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_2 PF00002.24 PIK40740.1 - 2.5e-14 53.2 0.8 3.6e-14 52.6 0.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) FA_desaturase PF00487.24 PIK40740.1 - 0.61 9.9 4.6 1.2 8.9 4.5 1.4 1 1 1 2 2 2 0 Fatty acid desaturase TMEM208_SND2 PF05620.11 PIK40740.1 - 3.2 7.5 7.3 7.4 6.3 7.3 1.7 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Surfac_D-trimer PF09006.11 PIK40742.1 - 0.012 15.5 0.5 16 5.5 0.1 3.4 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation Pox_I6 PF04595.13 PIK40742.1 - 0.023 13.7 0.1 0.036 13.0 0.1 1.4 1 0 0 1 1 1 0 Poxvirus I6-like family Peptidase_S66 PF02016.15 PIK40742.1 - 0.5 10.5 2.9 0.5 10.5 0.8 1.9 1 1 1 2 2 2 0 LD-carboxypeptidase N-terminal domain TMCO5 PF14992.6 PIK40742.1 - 0.66 9.5 14.4 0.9 9.1 5.1 2.2 1 1 1 2 2 2 0 TMCO5 family DUF4407 PF14362.6 PIK40742.1 - 1.1 8.6 10.7 1.6 8.0 10.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1515 PF07439.11 PIK40742.1 - 7.2 6.7 8.0 1.9 8.6 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Mito_carr PF00153.27 PIK40743.1 - 4.2e-54 180.5 2.0 2.3e-18 65.9 0.0 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein Xan_ur_permease PF00860.20 PIK40744.1 - 8.6e-69 232.1 27.8 3.9e-41 141.0 7.6 2.0 2 0 0 2 2 2 2 Permease family MFS_MOT1 PF16983.5 PIK40744.1 - 5.5 7.4 20.5 0.17 12.3 2.3 3.9 2 2 1 3 3 3 0 Molybdate transporter of MFS superfamily zf-CCHC PF00098.23 PIK40745.1 - 0.024 14.7 6.2 0.024 14.7 6.2 2.0 2 0 0 2 2 2 0 Zinc knuckle DUF5338 PF17273.2 PIK40745.1 - 0.031 14.3 0.0 0.38 10.9 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5338) TPR_10 PF13374.6 PIK40745.1 - 0.07 13.0 1.8 5.2 7.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CLZ PF16526.5 PIK40745.1 - 0.3 11.5 2.3 6.2 7.3 0.8 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RVT_1 PF00078.27 PIK40746.1 - 7.3e-26 91.1 0.0 1.1e-25 90.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK40747.1 - 4.3e-14 52.7 0.3 1.7e-13 50.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40747.1 - 8.3e-13 48.2 0.4 1.6e-11 44.1 0.1 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK40747.1 - 3.2e-05 23.6 0.7 8.2e-05 22.3 0.1 2.1 2 0 0 2 2 2 1 Integrase core domain PNISR PF15996.5 PIK40748.1 - 4.3e-40 138.2 15.2 4.3e-40 138.2 15.2 4.6 4 1 0 4 4 4 1 Arginine/serine-rich protein PNISR Methyltransf_11 PF08241.12 PIK40749.1 - 2.2e-18 66.7 0.1 3.9e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK40749.1 - 6.1e-16 58.7 0.0 1.4e-15 57.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK40749.1 - 2.8e-15 56.8 0.1 7e-15 55.5 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK40749.1 - 1.3e-13 51.5 0.0 2.8e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK40749.1 - 1.2e-10 41.3 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK40749.1 - 5e-08 32.7 0.1 7.2e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 PIK40749.1 - 4.7e-05 22.8 0.0 5.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 PIK40749.1 - 0.00012 22.1 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK40749.1 - 0.00014 21.3 0.0 0.0002 20.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 PIK40749.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 PIK40749.1 - 0.0044 16.6 0.1 0.0083 15.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 PIK40749.1 - 0.01 15.4 0.2 0.029 14.0 0.2 1.7 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 PIK40749.1 - 0.073 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 PIK40749.1 - 0.089 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 PIK40749.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB RrnaAD PF00398.20 PIK40749.1 - 0.11 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMS1 PF14617.6 PIK40750.1 - 2.6e-28 99.0 2.4 3.5e-28 98.6 2.4 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 PIK40750.1 - 7.4e-05 22.6 0.1 0.00012 21.9 0.1 1.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Nop14 PF04147.12 PIK40750.1 - 0.00033 19.1 2.6 0.00038 18.8 2.6 1.0 1 0 0 1 1 1 1 Nop14-like family Pkinase_Tyr PF07714.17 PIK40751.1 - 5.3e-47 160.3 0.0 6.7e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40751.1 - 1.2e-13 51.0 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TPR_1 PF00515.28 PIK40752.1 - 1.2e-41 138.8 9.4 1.5e-06 27.7 0.1 11.9 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_2 PF07719.17 PIK40752.1 - 2.5e-40 133.4 0.1 0.00016 21.5 0.0 12.1 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_12 PF13424.6 PIK40752.1 - 7.7e-30 103.0 0.1 4.1e-08 33.4 0.0 8.7 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 PIK40752.1 - 2.1e-24 84.5 4.6 0.0024 18.4 0.0 10.8 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK40752.1 - 5.3e-22 76.2 8.0 0.003 17.5 0.0 11.1 13 0 0 13 13 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK40752.1 - 1.6e-21 74.7 24.4 0.0022 18.0 0.0 12.7 14 0 0 14 14 13 5 Tetratricopeptide repeat TPR_19 PF14559.6 PIK40752.1 - 1.8e-18 66.8 0.0 0.0051 17.3 0.0 7.2 6 2 2 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK40752.1 - 8.7e-14 51.5 13.0 0.00084 19.5 0.2 6.3 4 1 1 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 PIK40752.1 - 5.4e-13 49.4 0.0 0.01 16.5 0.0 6.7 4 3 3 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK40752.1 - 1e-11 44.3 2.2 0.078 12.7 0.1 7.9 6 2 3 9 9 9 2 TPR repeat TPR_14 PF13428.6 PIK40752.1 - 1e-11 44.6 0.0 0.58 11.1 0.0 9.0 5 3 4 10 10 8 1 Tetratricopeptide repeat SNAP PF14938.6 PIK40752.1 - 1.6e-09 37.6 14.1 6.9e-08 32.2 0.2 5.2 2 2 3 5 5 5 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 PIK40752.1 - 4e-08 33.1 2.5 7 7.3 0.0 7.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK40752.1 - 7.9e-07 29.1 0.0 0.32 11.2 0.0 5.2 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK40752.1 - 1.5e-06 27.9 2.9 0.43 10.5 0.0 7.2 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK40752.1 - 2.4e-05 24.2 4.2 0.0038 17.0 0.4 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 PIK40752.1 - 0.00014 21.1 1.2 0.019 14.2 0.0 3.8 2 1 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK40752.1 - 0.00073 19.6 4.7 16 5.7 0.1 6.3 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 PIK40752.1 - 0.0079 16.8 4.3 6.7 7.6 0.1 4.7 4 0 0 4 4 4 1 Sel1 repeat TPR_MalT PF17874.1 PIK40752.1 - 0.034 13.5 0.1 7 5.9 0.0 4.0 3 1 2 6 6 6 0 MalT-like TPR region Wzy_C_2 PF11846.8 PIK40752.1 - 0.068 13.1 0.1 10 6.0 0.0 3.5 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal Lipin_mid PF16876.5 PIK40752.1 - 0.14 12.3 0.4 0.45 10.7 0.4 1.9 1 0 0 1 1 1 0 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF2225 PF09986.9 PIK40752.1 - 0.33 10.7 12.0 0.79 9.4 1.7 4.1 2 2 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) PPR_2 PF13041.6 PIK40752.1 - 1.6 9.0 3.5 43 4.4 0.0 4.6 6 0 0 6 6 5 0 PPR repeat family TPR_3 PF07720.12 PIK40752.1 - 3.7 7.6 15.9 6.8 6.8 0.1 6.6 7 1 1 8 8 7 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK40752.1 - 4 7.1 14.5 0.064 13.0 1.2 4.5 5 2 1 6 6 6 0 26S proteasome subunit RPN7 Pkinase_Tyr PF07714.17 PIK40753.1 - 5.5e-58 196.3 0.0 8.1e-58 195.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK40753.1 - 1.8e-55 188.1 0.0 5e-55 186.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 PIK40753.1 - 0.04 13.8 0.0 0.21 11.5 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family rve PF00665.26 PIK40754.1 - 3.5e-23 82.1 0.0 4.2e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK40754.1 - 1.2e-05 25.1 0.0 1.4e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.6 PIK40754.1 - 1.8e-05 24.4 0.0 3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK40754.1 - 0.018 15.3 0.0 0.022 15.0 0.0 1.1 1 0 0 1 1 1 0 DDE domain RT_RNaseH_2 PF17919.1 PIK40755.1 - 5.3e-37 125.9 0.0 8.4e-37 125.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK40755.1 - 7.6e-36 122.6 0.0 1.2e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK40755.1 - 0.001 19.2 0.1 0.0019 18.3 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain DNA_pol_viral_C PF00336.18 PIK40755.1 - 0.044 13.2 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Retrotrans_gag PF03732.17 PIK40756.1 - 2.6e-05 24.4 0.0 0.00012 22.3 0.0 2.0 1 1 1 2 2 2 1 Retrotransposon gag protein zf-CCHC PF00098.23 PIK40756.1 - 0.0015 18.5 18.9 0.0055 16.7 3.6 2.8 3 0 0 3 3 3 2 Zinc knuckle RNase_T PF00929.24 PIK40756.1 - 0.014 16.0 0.0 0.022 15.3 0.0 1.3 1 0 0 1 1 1 0 Exonuclease NinD PF17466.2 PIK40756.1 - 6.4 6.9 8.9 2.3 8.3 2.2 2.5 2 0 0 2 2 2 0 Family of unknown function Tubulin PF00091.25 PIK40757.1 - 8.7e-66 221.9 0.0 1.2e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK40757.1 - 4.4e-51 172.3 0.0 7.5e-51 171.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK40757.1 - 0.00087 19.0 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain APG5 PF04106.12 PIK40758.1 - 7e-63 212.3 2.0 9e-63 211.9 2.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 MFS_1 PF07690.16 PIK40759.1 - 7.9e-11 41.5 14.6 7.9e-11 41.5 14.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK40759.1 - 2.5e-09 36.5 5.3 3.1e-09 36.2 5.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 PIK40759.1 - 3.9e-05 23.1 4.5 6.1e-05 22.5 4.5 1.3 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB SARS_X4 PF08779.10 PIK40759.1 - 0.07 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 SARS coronavirus X4 like Homeodomain PF00046.29 PIK40760.1 - 2e-14 53.2 3.6 3.7e-14 52.3 3.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK40760.1 - 0.00061 19.6 0.3 0.0022 17.8 0.3 2.0 2 0 0 2 2 2 1 Homeobox KN domain MRP-L20 PF12824.7 PIK40760.1 - 0.014 15.6 1.5 0.031 14.4 1.5 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 Phospholamban PF04272.14 PIK40760.1 - 0.043 13.3 0.7 0.14 11.7 0.7 1.9 1 0 0 1 1 1 0 Phospholamban HTH_32 PF13565.6 PIK40760.1 - 0.069 13.8 0.5 0.14 12.8 0.5 1.6 1 0 0 1 1 1 0 Homeodomain-like domain AMPK1_CBM PF16561.5 PIK40761.1 - 3.7e-21 75.1 0.1 7.7e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 PIK40761.1 - 0.0075 16.6 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) FTHFS PF01268.19 PIK40762.1 - 3.1e-197 656.2 0.0 1.6e-166 554.8 0.0 2.2 1 1 1 2 2 2 2 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 PIK40762.1 - 2.3e-63 212.3 0.3 5.6e-63 211.0 0.3 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 PIK40762.1 - 1.2e-28 99.7 1.6 2.5e-28 98.6 1.6 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain TBP PF00352.21 PIK40763.1 - 9.8e-62 204.9 0.2 5e-33 112.9 0.1 2.5 3 0 0 3 3 3 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 PIK40763.1 - 9.3e-05 22.5 0.0 0.63 10.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Atg14 PF10186.9 PIK40764.1 - 2.1e-36 125.6 6.9 3.6e-36 124.9 6.9 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2748 PF10871.8 PIK40764.1 - 0.15 10.7 5.6 0.23 10.1 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) Exonuc_VII_L PF02601.15 PIK40764.1 - 0.33 10.5 15.8 0.54 9.8 15.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1043 PF06295.12 PIK40764.1 - 0.88 9.6 23.1 0.14 12.2 13.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) CENP-Q PF13094.6 PIK40764.1 - 6.5 6.9 27.4 1.8e+02 2.2 26.7 2.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FSIP1 PF15554.6 PIK40765.1 - 1.9e-86 290.7 31.3 1.9e-86 290.7 31.3 2.0 2 0 0 2 2 2 1 FSIP1 family CorA PF01544.18 PIK40765.1 - 0.16 11.3 6.3 0.42 9.9 1.5 2.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Plasmid_RAQPRD PF09686.10 PIK40765.1 - 0.21 11.8 8.1 0.72 10.1 1.0 2.7 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Cupin_4 PF08007.12 PIK40766.1 - 5.9e-68 229.7 0.0 9.5e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 PIK40766.1 - 1.2e-06 28.5 0.0 1.2e-06 28.5 0.0 3.4 2 2 0 2 2 2 1 Cupin-like domain Cupin_1 PF00190.22 PIK40766.1 - 0.013 15.2 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Cupin Cupin_2 PF07883.11 PIK40766.1 - 0.015 15.0 0.0 0.25 11.1 0.0 2.5 2 0 0 2 2 2 0 Cupin domain MAS20 PF02064.15 PIK40767.1 - 1.2e-43 148.2 0.1 1.7e-43 147.8 0.1 1.2 1 0 0 1 1 1 1 MAS20 protein import receptor NtCtMGAM_N PF16863.5 PIK40768.1 - 1.1e-30 106.2 0.2 1.5e-30 105.8 0.2 1.1 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 PIK40768.1 - 4e-08 33.0 0.7 6.3e-08 32.4 0.7 1.3 1 0 0 1 1 1 1 Trefoil (P-type) domain DUF4973 PF16343.5 PIK40768.1 - 0.12 12.4 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4973) Glyco_hydro_31 PF01055.26 PIK40769.1 - 2.5e-147 491.6 5.6 2.9e-147 491.4 5.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 PIK40769.1 - 1.6e-05 25.1 0.0 4.4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) GP17 PF17420.2 PIK40769.1 - 0.63 10.2 3.0 0.51 10.5 0.2 2.2 2 0 0 2 2 2 0 Superinfection exclusion gene product 17 Metallophos PF00149.28 PIK40770.1 - 2.2e-11 44.6 0.1 2.9e-11 44.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK40770.1 - 8.3e-05 22.8 0.0 0.00025 21.3 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain zf-RING_2 PF13639.6 PIK40771.1 - 1.6e-06 28.3 1.8 1.6e-06 28.3 1.8 2.5 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.29 PIK40771.1 - 0.0073 16.2 4.2 0.0073 16.2 4.2 2.5 1 1 1 2 2 2 1 PHD-finger PHD_4 PF16866.5 PIK40771.1 - 0.023 14.8 14.5 0.31 11.2 4.1 3.0 1 1 1 2 2 2 0 PHD-finger DUF2175 PF09943.9 PIK40771.1 - 0.029 14.7 0.0 0.082 13.2 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DSHCT PF08148.12 PIK40771.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain zf-B_box PF00643.24 PIK40771.1 - 0.88 9.8 18.5 0.12 12.6 8.2 3.0 3 0 0 3 3 3 0 B-box zinc finger Y_phosphatase PF00102.27 PIK40772.1 - 1.1e-109 365.5 0.1 4.4e-69 232.6 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Ig_3 PF13927.6 PIK40772.1 - 2e-17 63.5 0.1 3.7e-08 33.8 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK40772.1 - 4e-13 49.3 0.1 5.3e-06 26.5 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK40772.1 - 5.2e-13 49.1 0.5 3.2e-05 24.2 0.0 3.3 3 0 0 3 3 2 2 Immunoglobulin domain I-set PF07679.16 PIK40772.1 - 1.3e-11 44.4 0.0 0.00024 21.1 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK40772.1 - 2.4e-06 27.7 0.1 0.14 12.3 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin V-set domain fn3 PF00041.21 PIK40772.1 - 9.8e-06 25.8 4.1 0.15 12.5 0.3 4.6 4 1 0 4 4 3 2 Fibronectin type III domain DSPc PF00782.20 PIK40772.1 - 0.0011 18.8 0.3 2.1 8.2 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Stevor PF17410.2 PIK40772.1 - 0.0017 17.9 1.4 0.0034 17.0 1.4 1.4 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame C2-set_2 PF08205.12 PIK40772.1 - 0.0034 17.4 0.1 0.52 10.4 0.0 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain PTPlike_phytase PF14566.6 PIK40772.1 - 0.0041 17.2 0.1 0.024 14.8 0.0 2.3 2 0 0 2 2 2 1 Inositol hexakisphosphate Myotub-related PF06602.14 PIK40772.1 - 0.013 14.4 0.2 1.4 7.7 0.0 2.7 3 0 0 3 3 3 0 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 PIK40772.1 - 0.031 14.2 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family PRCC PF10253.9 PIK40772.1 - 0.33 11.7 1.6 0.65 10.8 1.6 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting LRR_4 PF12799.7 PIK40773.1 - 8.2e-08 32.4 4.3 0.0041 17.5 0.1 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK40773.1 - 4e-05 23.3 12.8 0.3 11.2 0.1 5.2 5 1 1 6 6 6 3 Leucine Rich repeat LRR_8 PF13855.6 PIK40773.1 - 4.4e-05 23.2 8.2 0.033 14.0 1.6 3.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 PIK40773.1 - 0.0069 16.8 6.7 3.3 8.6 0.0 4.7 4 1 1 5 5 5 2 Leucine Rich Repeat DUF4957 PF16318.5 PIK40773.1 - 0.021 14.7 0.3 0.58 10.1 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4957) LRR_9 PF14580.6 PIK40773.1 - 0.059 12.9 1.2 0.1 12.1 1.1 1.4 1 1 0 1 1 1 0 Leucine-rich repeat Phospholip_A2_1 PF00068.19 PIK40774.1 - 7.8e-27 94.0 12.7 1.1e-26 93.4 12.7 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.12 PIK40774.1 - 0.024 14.8 15.7 0.026 14.8 5.4 2.4 1 1 1 2 2 2 0 Phospholipase A2 Sel1 PF08238.12 PIK40775.1 - 3e-16 59.5 4.2 0.00021 21.8 0.0 5.2 5 0 0 5 5 5 3 Sel1 repeat Tim17 PF02466.19 PIK40776.1 - 2.8e-09 37.3 1.9 3.6e-09 37.0 1.9 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 7tm_1 PF00001.21 PIK40777.1 - 4.4e-28 98.3 1.8 6.3e-28 97.8 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK40777.1 - 1.3e-07 31.3 6.5 9.6e-07 28.4 6.5 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK40777.1 - 1.4e-06 27.8 9.7 8.9e-05 21.9 0.3 3.1 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK40777.1 - 0.0001 22.0 1.0 0.0001 22.0 1.0 2.3 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4834 PF16118.5 PIK40777.1 - 0.034 15.1 0.0 0.034 15.1 0.0 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Shisa PF13908.6 PIK40777.1 - 0.4 10.9 3.2 0.57 10.4 0.1 2.4 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator Orf78 PF06024.12 PIK40777.1 - 0.93 9.8 4.6 7.8 6.9 0.0 3.3 4 0 0 4 4 4 0 Orf78 (ac78) HemY_N PF07219.13 PIK40777.1 - 3.2 8.0 0.0 3.2 8.0 0.0 2.8 3 0 0 3 3 3 0 HemY protein N-terminus 7tm_1 PF00001.21 PIK40778.1 - 4.2e-22 78.7 4.1 5.3e-22 78.4 4.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK40778.1 - 0.00057 19.7 2.2 0.00066 19.5 2.2 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK40778.1 - 0.0039 16.6 4.8 0.0049 16.3 4.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK40778.1 - 0.042 13.5 9.0 0.034 13.8 8.0 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK40779.1 - 7.7e-43 146.7 11.6 1e-42 146.3 11.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK40779.1 - 2.2e-09 37.4 12.8 2.2e-09 37.4 12.8 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK40779.1 - 0.0062 15.9 0.8 0.0062 15.9 0.8 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 PIK40779.1 - 0.24 11.1 19.0 0.88 9.2 5.4 3.0 2 1 1 3 3 3 0 Olfactory receptor CelTOS PF18659.1 PIK40780.1 - 0.076 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites SAM_1 PF00536.30 PIK40781.1 - 4.2e-29 100.8 0.0 5.2e-14 52.4 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK40781.1 - 7.6e-23 80.4 0.0 1.2e-12 47.7 0.0 2.9 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) RalF_SCD PF18248.1 PIK40782.1 - 0.12 12.3 0.2 9.1 6.2 0.0 2.8 3 0 0 3 3 3 0 RalF C-terminal Sec-7 capping domain Secretin_N_2 PF07655.13 PIK40782.1 - 2 9.0 11.1 0.09 13.3 1.6 2.8 3 1 0 3 3 3 0 Secretin N-terminal domain PKD_channel PF08016.12 PIK40783.1 - 3.3e-101 339.0 9.8 3.3e-101 339.0 9.8 1.5 2 0 0 2 2 2 1 Polycystin cation channel REJ PF02010.15 PIK40783.1 - 1.2e-39 136.4 0.0 1.8e-39 135.8 0.0 1.3 1 0 0 1 1 1 1 REJ domain PLAT PF01477.23 PIK40783.1 - 3.1e-18 66.5 0.1 1.2e-17 64.5 0.1 2.0 2 0 0 2 2 2 1 PLAT/LH2 domain Ion_trans PF00520.31 PIK40783.1 - 4e-14 52.4 30.5 8.8e-14 51.3 28.5 2.6 3 0 0 3 3 3 1 Ion transport protein GPS PF01825.21 PIK40783.1 - 2.9e-05 24.5 2.2 7.1e-05 23.3 2.2 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD PF00801.20 PIK40784.1 - 7.2e-06 25.8 11.7 0.77 9.6 0.0 6.0 5 1 0 5 5 5 4 PKD domain PKD PF00801.20 PIK40785.1 - 5.5e-06 26.1 2.7 4e-05 23.4 1.1 3.0 4 0 0 4 4 4 1 PKD domain Cadherin_C_2 PF16492.5 PIK40786.1 - 0.013 16.2 1.8 0.049 14.4 0.1 2.4 1 1 1 2 2 2 0 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 PIK40786.1 - 0.018 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family DAG1 PF05454.11 PIK40786.1 - 0.12 11.8 8.4 0.94 8.8 8.4 2.1 1 1 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF2207 PF09972.9 PIK40786.1 - 0.15 10.8 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Gln-synt_C PF00120.24 PIK40787.1 - 1.4e-72 244.6 0.0 2.1e-72 244.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 PIK40787.1 - 2.8e-07 30.3 0.0 5.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain Gln-synt_N PF03951.19 PIK40787.1 - 0.017 14.9 0.0 0.079 12.7 0.0 2.1 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain Shisa PF13908.6 PIK40789.1 - 0.16 12.2 0.5 0.19 12.0 0.5 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator zf-RanBP PF00641.18 PIK40790.1 - 4.9e-14 51.3 19.1 5.3e-09 35.2 4.6 2.2 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 PIK40790.1 - 0.0068 16.3 6.4 0.14 12.1 0.5 2.2 2 0 0 2 2 2 2 Rubredoxin-like zinc ribbon domain (DUF35_N) RecR PF02132.15 PIK40790.1 - 6.8 6.3 10.7 0.86 9.2 0.7 2.7 2 1 0 2 2 2 0 RecR protein VCBS PF13517.6 PIK40791.1 - 1.8e-08 34.8 11.6 5.9e-05 23.6 1.0 5.2 5 1 0 5 5 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK40791.1 - 0.0036 17.4 1.6 0.0036 17.4 1.6 5.3 4 1 0 4 4 4 2 FG-GAP repeat NOA36 PF06524.12 PIK40791.1 - 0.017 14.4 21.1 0.024 13.9 21.1 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 PIK40791.1 - 0.23 9.5 24.1 0.31 9.1 24.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 PIK40791.1 - 0.91 9.5 9.1 1.6 8.8 9.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.12 PIK40791.1 - 1.8 6.7 14.3 2.2 6.4 14.3 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK40791.1 - 2.1 7.7 14.8 2.8 7.3 14.8 1.1 1 0 0 1 1 1 0 SDA1 TFB6 PF17110.5 PIK40791.1 - 3.9 7.2 7.7 8 6.2 7.7 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FAM176 PF14851.6 PIK40791.1 - 4.1 7.1 5.9 8 6.1 5.9 1.4 1 0 0 1 1 1 0 FAM176 family DUF2457 PF10446.9 PIK40791.1 - 4.5 6.3 31.0 6.4 5.8 31.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PPP4R2 PF09184.11 PIK40791.1 - 8.1 5.9 11.4 11 5.4 11.4 1.2 1 0 0 1 1 1 0 PPP4R2 zf-CCHC_3 PF13917.6 PIK40792.1 - 1e-08 35.0 0.0 2.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Zinc knuckle CpXC PF14353.6 PIK40792.1 - 0.046 13.8 2.9 0.097 12.7 2.9 1.7 1 1 0 1 1 1 0 CpXC protein LYRIC PF15686.5 PIK40792.1 - 0.049 13.2 26.2 0.069 12.7 26.2 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family CDC45 PF02724.14 PIK40792.1 - 0.17 10.2 28.7 0.22 9.8 28.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Glypican PF01153.19 PIK40792.1 - 0.99 8.2 10.8 1.3 7.8 10.8 1.1 1 0 0 1 1 1 0 Glypican Smg8_Smg9 PF10220.9 PIK40792.1 - 1.2 7.3 12.3 1.4 7.2 12.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Y_phosphatase PF00102.27 PIK40793.1 - 4.9e-31 108.1 1.7 5.9e-31 107.8 1.7 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF1648 PF07853.11 PIK40794.1 - 0.22 11.2 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) UCH PF00443.29 PIK40795.1 - 3.6e-15 56.2 0.1 4.5e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK40795.1 - 5e-06 26.3 0.3 7.6e-06 25.7 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Sortilin_C PF15901.5 PIK40795.1 - 0.014 15.8 0.3 0.028 14.8 0.0 1.6 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, C-terminal PNP_UDP_1 PF01048.20 PIK40796.1 - 6.7e-44 149.9 0.0 8.2e-44 149.6 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily RRM_1 PF00076.22 PIK40797.1 - 2.5e-20 72.1 0.1 7e-12 45.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK40797.1 - 0.0053 16.8 2.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 PIK40797.1 - 0.0057 16.2 0.0 0.4 10.3 0.0 2.4 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 PIK40797.1 - 0.02 15.5 26.7 0.033 14.8 26.7 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF755 PF05501.11 PIK40797.1 - 0.035 14.4 10.3 0.06 13.6 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF441 PF04284.13 PIK40797.1 - 0.052 13.6 0.3 0.095 12.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF441) RRM_occluded PF16842.5 PIK40797.1 - 0.057 13.3 0.0 0.85 9.5 0.0 2.4 2 1 0 2 2 2 0 Occluded RNA-recognition motif DUF1509 PF07420.11 PIK40797.1 - 0.96 8.3 8.5 1.4 7.8 8.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) CDC45 PF02724.14 PIK40797.1 - 1.4 7.1 4.2 1.8 6.7 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein PAC3 PF10178.9 PIK40798.1 - 3.9e-18 65.4 0.0 7.1e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 MULE PF10551.9 PIK40798.1 - 0.00053 20.4 0.1 0.0021 18.4 0.1 2.0 2 0 0 2 2 2 1 MULE transposase domain DUF5580 PF17743.1 PIK40799.1 - 9.2e-18 64.1 3.2 1.3e-11 43.8 0.1 3.1 3 0 0 3 3 3 3 Family of unknown function (DUF5580) EF-hand_6 PF13405.6 PIK40799.1 - 0.013 15.4 0.0 0.045 13.7 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain Actin PF00022.19 PIK40799.1 - 0.17 10.4 2.3 0.24 10.0 2.3 1.1 1 0 0 1 1 1 0 Actin AP_endonuc_2 PF01261.24 PIK40800.1 - 3.5e-28 98.5 0.0 5e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel RFX_DNA_binding PF02257.15 PIK40801.1 - 2.1e-34 118.0 0.1 1.3e-33 115.5 0.1 2.5 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 PIK40801.1 - 0.031 14.8 0.1 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 Poxvirus D5 protein-like bZIP_C PF12498.8 PIK40801.1 - 0.35 11.9 8.4 6.4 7.8 2.5 3.5 3 0 0 3 3 3 0 Basic leucine-zipper C terminal Dynactin_p22 PF07426.11 PIK40801.1 - 0.73 9.7 3.9 1.5 8.7 0.0 2.8 3 0 0 3 3 3 0 Dynactin subunit p22 Ndc1_Nup PF09531.10 PIK40802.1 - 9.3e-58 196.4 0.3 1.2e-57 196.0 0.3 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup PDZ PF00595.24 PIK40803.1 - 1.2e-19 70.5 0.1 1.7e-19 70.0 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK40803.1 - 8.7e-10 38.3 0.0 1.3e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK40803.1 - 4.6e-07 30.1 0.1 9.6e-07 29.0 0.1 1.6 1 1 0 1 1 1 1 PDZ domain zf-C2H2 PF00096.26 PIK40804.1 - 5e-13 48.7 11.3 0.0019 18.5 0.3 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK40804.1 - 1e-07 32.1 8.8 0.0083 16.9 0.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK40804.1 - 5.5e-06 26.6 15.6 1e-05 25.7 0.9 3.8 4 0 0 4 4 4 2 Zinc-finger double domain FOXP-CC PF16159.5 PIK40804.1 - 0.0013 19.3 4.7 0.18 12.4 0.2 2.9 1 1 2 3 3 3 2 FOXP coiled-coil domain Phage_integrase PF00589.22 PIK40804.1 - 0.023 14.5 0.0 0.057 13.2 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family zf-C2H2_8 PF15909.5 PIK40804.1 - 0.056 13.7 4.2 0.096 13.0 1.4 2.4 2 1 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 PIK40804.1 - 0.41 11.0 3.4 51 4.3 0.8 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.12 PIK40804.1 - 1 10.1 5.3 5.5 7.8 0.6 2.8 2 1 1 3 3 3 0 CHORD RVT_3 PF13456.6 PIK40805.1 - 0.031 14.1 0.0 0.07 12.9 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like RVT_1 PF00078.27 PIK40806.1 - 2.3e-12 46.9 0.0 3.6e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F5_F8_type_C PF00754.25 PIK40808.1 - 2.7e-06 27.5 0.0 3.8e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain ANAPC10 PF03256.16 PIK40808.1 - 0.00086 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Sad1_UNC PF07738.13 PIK40808.1 - 0.042 13.9 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal DUF1754 PF08555.10 PIK40809.1 - 2e-08 35.0 13.0 1.1e-06 29.4 13.0 2.0 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) DUF4656 PF15551.6 PIK40809.1 - 0.025 14.1 0.9 0.026 14.0 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4656) zf-C2H2 PF00096.26 PIK40810.1 - 0.00081 19.7 3.1 0.015 15.7 1.0 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-TRAF PF02176.18 PIK40810.1 - 0.058 14.1 7.4 0.18 12.5 0.9 2.9 1 1 1 2 2 2 0 TRAF-type zinc finger FOXP-CC PF16159.5 PIK40810.1 - 0.47 11.1 11.2 0.15 12.7 0.9 3.2 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 PIK40810.1 - 0.6 11.1 6.5 1.2 10.1 1.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 PIK40810.1 - 2.4 8.7 4.5 7.7 7.1 0.9 2.8 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain CHORD PF04968.12 PIK40810.1 - 3.3 8.5 8.5 18 6.1 0.2 2.9 3 0 0 3 3 3 0 CHORD Ras PF00071.22 PIK40813.1 - 3.1e-32 111.4 0.0 4.2e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK40813.1 - 1.8e-13 50.8 0.0 3.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK40813.1 - 0.0055 16.2 0.0 0.011 15.2 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK40813.1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Xpo1 PF08389.12 PIK40814.1 - 1.4e-26 93.4 0.6 4.5e-25 88.5 0.2 3.4 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 PIK40814.1 - 2.8e-06 27.2 3.9 4.9e-06 26.4 1.6 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain BRK PF07533.16 PIK40814.1 - 0.076 12.7 0.1 0.23 11.1 0.1 1.8 1 0 0 1 1 1 0 BRK domain DUF3187 PF11383.8 PIK40819.1 - 0.053 12.7 0.0 0.067 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3187) Ras PF00071.22 PIK40821.1 - 3.1e-28 98.4 0.0 3.9e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK40821.1 - 0.00096 19.4 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK40821.1 - 0.04 13.4 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family COesterase PF00135.28 PIK40822.1 - 3e-28 99.0 0.0 3.5e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK40822.1 - 0.062 13.2 0.1 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF3141 PF11339.8 PIK40822.1 - 0.13 10.6 0.0 0.14 10.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) COesterase PF00135.28 PIK40823.1 - 3.7e-29 102.0 0.0 4.2e-29 101.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK40824.1 - 7.1e-126 421.1 0.0 8.1e-126 420.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK40824.1 - 0.0069 16.3 0.0 0.028 14.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK40825.1 - 1.2e-102 344.5 0.0 1.3e-102 344.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK40825.1 - 4.7e-06 26.6 0.1 2e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 PIK40825.1 - 0.17 10.7 0.0 0.44 9.3 0.0 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Fibrinogen_C PF00147.18 PIK40826.1 - 9.1e-43 146.6 1.2 1.4e-42 146.0 1.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK40826.1 - 1.4e-05 25.2 9.8 1.4e-05 25.2 9.8 3.8 2 2 1 3 3 3 1 EGF domain TILa PF12714.7 PIK40826.1 - 0.00021 21.1 5.1 0.00021 21.1 5.1 3.2 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK40826.1 - 0.00061 20.0 9.2 0.00061 20.0 9.2 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK40826.1 - 4.2 7.8 25.9 2.5 8.6 9.0 4.0 3 2 0 3 3 3 0 EGF-like domain TILa PF12714.7 PIK40827.1 - 1.1e-10 41.3 17.9 1.9e-05 24.5 3.5 2.7 2 1 0 2 2 2 2 TILa domain EGF_3 PF12947.7 PIK40827.1 - 3.2e-10 40.0 37.2 1.2e-05 25.4 9.5 4.3 3 1 1 4 4 4 2 EGF domain Fibrinogen_C PF00147.18 PIK40827.1 - 7.6e-10 39.0 0.1 1.7e-09 37.8 0.1 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_MSP1_1 PF12946.7 PIK40827.1 - 6.3e-06 26.1 20.2 0.00057 19.9 5.8 3.2 4 0 0 4 4 4 2 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK40827.1 - 0.00071 19.9 30.2 0.022 15.1 9.9 3.5 2 2 0 2 2 2 2 EGF-like domain Caprin-1_C PF12287.8 PIK40827.1 - 0.58 10.3 4.0 3.1 7.9 0.2 2.1 1 1 0 2 2 2 0 Cytoplasmic activation/proliferation-associated protein-1 C term Fibrinogen_C PF00147.18 PIK40828.1 - 2.3e-33 115.9 0.5 3e-33 115.5 0.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Arf PF00025.21 PIK40829.1 - 1.6e-39 135.2 0.0 2.2e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK40829.1 - 1.1e-13 51.4 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK40829.1 - 2.4e-12 46.7 0.0 3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 PIK40829.1 - 1.2e-10 41.1 0.0 7.1e-07 28.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK40829.1 - 2.2e-07 30.9 0.0 3.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK40829.1 - 3.7e-07 29.7 0.0 4.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK40829.1 - 2.8e-06 26.9 0.0 3.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Peptidase_C1 PF00112.23 PIK40830.1 - 2e-68 230.8 7.0 3e-68 230.2 7.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK40830.1 - 2.3e-10 40.8 4.7 4.6e-10 39.8 4.7 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK40830.1 - 0.021 13.6 0.3 0.35 9.6 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family RIO1 PF01163.22 PIK40832.1 - 5.5e-30 104.4 2.7 4.2e-20 72.1 0.6 4.3 3 1 2 5 5 5 3 RIO1 family Mito_carr PF00153.27 PIK40833.1 - 2.6e-69 229.2 3.7 1.6e-25 88.8 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Cation_ATPase PF13246.6 PIK40833.1 - 0.17 12.0 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) WD40 PF00400.32 PIK40834.1 - 4.3e-23 81.1 4.3 4.1e-06 27.4 0.4 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat SH3_9 PF14604.6 PIK40834.1 - 2.5e-11 43.3 0.1 6e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK40834.1 - 3.9e-11 42.4 0.4 1e-10 41.1 0.4 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK40834.1 - 1.9e-10 40.2 0.1 5.8e-10 38.7 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain ANAPC4_WD40 PF12894.7 PIK40834.1 - 1.3e-07 31.8 0.0 0.73 10.2 0.0 5.5 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 PIK40834.1 - 0.071 12.8 0.0 2.5 7.8 0.0 2.9 2 0 0 2 2 2 0 TUP1-like enhancer of split Fibrinogen_C PF00147.18 PIK40835.1 - 1.1e-43 149.6 3.0 1.3e-34 119.9 0.5 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK40835.1 - 1.6e-06 28.2 8.5 1.6e-06 28.2 8.5 3.5 4 1 0 4 4 4 1 EGF domain TILa PF12714.7 PIK40835.1 - 1.9e-05 24.5 5.7 1.9e-05 24.5 5.7 3.5 1 1 2 3 3 3 1 TILa domain EGF_2 PF07974.13 PIK40835.1 - 1.1 9.7 25.6 0.051 14.0 11.0 4.0 3 2 0 3 3 3 0 EGF-like domain NACHT PF05729.12 PIK40836.1 - 1.1e-11 45.0 0.0 1.8e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK40836.1 - 0.032 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RRM_Rrp7 PF17799.1 PIK40837.1 - 0.0024 17.7 5.3 2.1 8.1 0.1 3.6 2 1 1 3 3 3 3 Rrp7 RRM-like N-terminal domain Ribonuc_2-5A PF06479.12 PIK40837.1 - 1.9 8.7 8.1 1.8 8.7 0.1 3.7 3 1 0 3 3 3 0 Ribonuclease 2-5A Fungal_TACC PF12709.7 PIK40838.1 - 1.1 9.7 4.9 0.35 11.4 0.5 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins zf-C2H2_4 PF13894.6 PIK40838.1 - 3.5 8.7 7.3 13 7.0 1.6 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger THAP PF05485.12 PIK40839.1 - 5.4e-12 46.5 0.2 3.3e-11 44.0 0.1 2.5 2 0 0 2 2 2 1 THAP domain Apt1 PF10351.9 PIK40841.1 - 0.00064 18.7 13.1 0.0012 17.8 13.1 1.3 1 1 0 1 1 1 1 Golgi-body localisation protein domain SARAF PF06682.12 PIK40841.1 - 0.00066 19.4 0.8 0.00092 18.9 0.8 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SAPS PF04499.15 PIK40841.1 - 0.0014 17.5 0.5 0.0019 17.1 0.5 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DUF4834 PF16118.5 PIK40841.1 - 0.0018 19.2 1.1 0.22 12.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) RNA_pol_Rpc4 PF05132.14 PIK40841.1 - 0.002 18.6 0.0 0.36 11.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase III RPC4 Rxt3 PF08642.10 PIK40841.1 - 0.0035 18.1 0.0 2.3 9.0 0.0 2.4 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 POX PF07526.11 PIK40841.1 - 0.0082 16.7 3.3 0.13 12.8 0.7 2.1 2 0 0 2 2 2 1 Associated with HOX Sigma70_ner PF04546.13 PIK40841.1 - 0.013 15.4 1.0 1.7 8.5 0.2 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region PRC2_HTH_1 PF18118.1 PIK40841.1 - 0.026 15.3 4.5 0.083 13.7 0.9 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain CCDC53 PF10152.9 PIK40841.1 - 0.027 14.9 1.2 1.6 9.1 0.1 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TRAP_alpha PF03896.16 PIK40841.1 - 0.056 12.6 1.1 0.25 10.5 0.0 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Pex14_N PF04695.13 PIK40841.1 - 0.095 13.3 9.9 2.3 8.8 4.5 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4667 PF15700.5 PIK40841.1 - 0.1 12.7 23.2 0.34 11.0 7.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) D123 PF07065.14 PIK40841.1 - 0.11 11.6 7.6 1.8 7.7 2.9 2.1 2 0 0 2 2 2 0 D123 Peroxin-13_N PF04088.13 PIK40841.1 - 0.16 12.2 0.4 0.85 9.9 0.0 1.9 2 0 0 2 2 2 0 Peroxin 13, N-terminal region CPSF100_C PF13299.6 PIK40841.1 - 0.17 12.0 1.6 2.2 8.5 0.2 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Lin-8 PF03353.15 PIK40841.1 - 0.71 9.4 9.1 1.2 8.6 9.1 1.3 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist RXT2_N PF08595.11 PIK40841.1 - 0.75 9.8 8.0 12 5.9 0.1 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal CDC45 PF02724.14 PIK40841.1 - 0.83 7.9 12.9 0.05 11.9 2.3 2.0 2 0 0 2 2 2 0 CDC45-like protein XAP5 PF04921.14 PIK40841.1 - 0.87 9.4 4.3 6.4 6.5 1.0 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF3464 PF11947.8 PIK40841.1 - 0.89 9.3 3.4 14 5.4 1.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TIMELESS PF04821.14 PIK40841.1 - 0.9 8.8 4.7 0.12 11.7 0.3 1.6 2 0 0 2 2 2 0 Timeless protein DUF4228 PF14009.6 PIK40841.1 - 1.7 9.0 10.8 24 5.3 10.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4228) RMP PF14996.6 PIK40841.1 - 2.3 8.5 7.4 15 5.8 3.2 2.1 2 0 0 2 2 2 0 Retinal Maintenance Nop14 PF04147.12 PIK40841.1 - 2.8 6.0 12.9 0.09 11.0 2.2 2.0 2 0 0 2 2 2 0 Nop14-like family TFB6 PF17110.5 PIK40841.1 - 3.6 7.3 6.2 25 4.6 3.5 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Presenilin PF01080.17 PIK40841.1 - 4 6.1 13.4 7 5.3 13.4 1.4 1 1 0 1 1 1 0 Presenilin FAM176 PF14851.6 PIK40841.1 - 4.1 7.1 10.6 2.2 7.9 2.2 2.3 2 0 0 2 2 2 0 FAM176 family SID-1_RNA_chan PF13965.6 PIK40841.1 - 5.5 5.3 4.7 0.72 8.2 0.1 1.7 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Ctr PF04145.15 PIK40841.1 - 5.7 7.6 10.9 3.2e+02 1.9 10.9 2.2 1 1 0 1 1 1 0 Ctr copper transporter family RRN3 PF05327.11 PIK40841.1 - 6.9 5.1 9.8 2.6 6.5 3.3 2.0 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Ank_5 PF13857.6 PIK40842.1 - 5.5e-12 45.7 0.0 1.3e-06 28.6 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK40842.1 - 1.4e-11 44.8 0.0 3.9e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK40842.1 - 8.2e-11 41.2 0.0 0.00021 21.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 PIK40842.1 - 2.9e-10 40.1 0.1 0.00081 19.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 PIK40842.1 - 1.5e-08 35.0 0.0 4.6e-08 33.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) AAA_9 PF12781.7 PIK40842.1 - 0.00065 18.9 0.0 0.00065 18.9 0.0 3.1 3 0 0 3 3 3 1 ATP-binding dynein motor region IQ PF00612.27 PIK40842.1 - 0.0065 16.2 1.3 0.024 14.4 1.3 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif BROMI PF14961.6 PIK40842.1 - 0.49 7.8 2.9 0.69 7.2 2.9 1.1 1 0 0 1 1 1 0 Broad-minded protein DUF4829 PF16111.5 PIK40842.1 - 8.7 7.2 11.9 12 6.7 0.8 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4829) Peptidase_C1 PF00112.23 PIK40843.1 - 1.4e-54 185.4 2.6 2e-54 185.0 2.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Somatomedin_B PF01033.17 PIK40843.1 - 0.0016 18.7 16.9 0.0016 18.7 16.9 3.0 3 0 0 3 3 3 1 Somatomedin B domain Peptidase_C1_2 PF03051.15 PIK40843.1 - 0.49 9.1 1.6 0.96 8.1 0.5 1.7 2 0 0 2 2 2 0 Peptidase C1-like family Peptidase_C1 PF00112.23 PIK40845.1 - 3.1e-56 190.9 0.2 4.5e-56 190.4 0.2 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 PIK40845.1 - 0.0064 15.3 0.2 0.33 9.7 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family RVT_1 PF00078.27 PIK40846.1 - 2.2e-10 40.4 0.1 2.2e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2703 PF10865.8 PIK40846.1 - 0.063 13.5 0.4 0.1 12.8 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2703) Radical_SAM_C PF16199.5 PIK40847.1 - 7.6e-34 115.6 0.0 1.6e-33 114.6 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 PIK40847.1 - 1.1e-20 74.7 0.4 1.2e-19 71.3 0.1 2.5 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 PIK40847.1 - 2.6e-09 37.3 0.1 4.6e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK40847.1 - 8.2e-05 22.6 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NUDIX PF00293.28 PIK40850.1 - 0.00024 21.1 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain DUF1897 PF09005.10 PIK40850.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) NUDIX PF00293.28 PIK40851.1 - 7.2e-08 32.5 0.0 0.056 13.5 0.0 3.5 2 1 0 2 2 2 2 NUDIX domain Serpin PF00079.20 PIK40853.1 - 2.3e-128 428.6 2.1 2.6e-128 428.5 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 PIK40855.1 - 1.4e-111 373.4 2.5 8.7e-111 370.8 2.5 1.8 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 PIK40856.1 - 9.3e-43 146.9 0.1 1e-42 146.8 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 PIK40857.1 - 3.2e-42 145.2 2.3 3.9e-42 144.9 2.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RITA PF17066.5 PIK40858.1 - 1.4e-10 41.2 9.2 3.4e-08 33.4 9.2 2.4 1 1 0 1 1 1 1 RBPJ-interacting and tubulin associated protein Rod_cone_degen PF15201.6 PIK40858.1 - 0.05 13.7 1.1 0.18 11.9 0.0 2.3 3 0 0 3 3 3 0 Progressive rod-cone degeneration WD40 PF00400.32 PIK40859.1 - 0.0037 18.1 3.9 0.087 13.7 0.0 3.7 4 1 0 4 4 4 1 WD domain, G-beta repeat MukB_hinge PF16330.5 PIK40859.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 MukB hinge domain DENN PF02141.21 PIK40860.1 - 6.4e-36 124.1 8.9 1.4e-35 122.9 8.9 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 PIK40860.1 - 4.6e-05 24.1 0.1 0.00025 21.7 0.1 2.4 1 0 0 1 1 1 1 uDENN domain TMEM18 PF14770.6 PIK40861.1 - 9.6e-42 141.7 8.0 1.2e-41 141.5 8.0 1.0 1 0 0 1 1 1 1 Transmembrane protein 18 FAM176 PF14851.6 PIK40861.1 - 0.1 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 FAM176 family SH PF01445.17 PIK40861.1 - 0.67 10.0 4.5 0.91 9.5 0.1 2.5 2 1 0 2 2 2 0 Viral small hydrophobic protein Bac_export_2 PF01312.19 PIK40861.1 - 6.9 5.8 6.3 3.1 6.9 3.9 1.5 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family Phage_holin_3_6 PF07332.11 PIK40861.1 - 8.1 6.5 10.3 7.1 6.7 0.3 2.4 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III COPIIcoated_ERV PF07970.12 PIK40863.1 - 1.2e-26 94.0 0.0 1.3e-26 93.8 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter DmsC PF04976.12 PIK40863.1 - 0.046 13.2 0.0 0.052 13.0 0.0 1.0 1 0 0 1 1 1 0 DMSO reductase anchor subunit (DmsC) Romo1 PF10247.9 PIK40864.1 - 2e-25 88.9 19.8 2.3e-25 88.8 19.8 1.0 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 PIK40864.1 - 0.023 15.1 8.7 0.025 14.9 8.7 1.0 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family ERGIC_N PF13850.6 PIK40865.1 - 1.1e-21 76.9 0.3 3.4e-21 75.4 0.1 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Toxin_TOLIP PF00087.21 PIK40865.1 - 0.082 13.2 18.2 7.7 6.8 0.1 4.8 3 1 2 5 5 5 0 Snake toxin and toxin-like protein DUF3156 PF11354.8 PIK40865.1 - 0.14 12.1 0.0 71 3.3 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3156) HD PF01966.22 PIK40866.1 - 5e-15 55.8 1.1 1.4e-13 51.1 1.1 2.6 1 1 0 1 1 1 1 HD domain SH3_2 PF07653.17 PIK40866.1 - 6.4e-07 28.9 0.0 1.8e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK40866.1 - 1e-05 25.3 0.0 2.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PDEase_I PF00233.19 PIK40866.1 - 0.0049 16.6 1.3 0.011 15.5 0.1 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase SH3_1 PF00018.28 PIK40866.1 - 0.018 14.6 0.0 0.051 13.2 0.0 1.8 1 0 0 1 1 1 0 SH3 domain RT_RNaseH PF17917.1 PIK40868.1 - 2.4e-28 98.5 0.0 4.3e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK40868.1 - 9.9e-28 96.1 0.0 1.8e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK40868.1 - 4.1e-22 78.1 0.1 8e-22 77.1 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK40868.1 - 3.8e-11 42.9 0.1 6.4e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK40868.1 - 0.0085 16.3 0.0 0.028 14.6 0.0 1.9 2 0 0 2 2 2 1 H2C2 zinc finger MARVEL PF01284.23 PIK40869.1 - 2e-10 40.8 21.4 6.4e-10 39.2 21.0 1.9 1 1 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 PIK40869.1 - 0.81 7.9 14.9 1 7.6 14.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PHB_acc_N PF07879.11 PIK40870.1 - 0.078 13.1 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain FRB_dom PF08771.11 PIK40871.1 - 0.15 12.5 1.0 0.72 10.3 0.2 2.0 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain EGF PF00008.27 PIK40872.1 - 9.7e-07 29.0 30.3 1.1e-06 28.8 7.4 3.1 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 PIK40872.1 - 1.9e-05 25.1 7.0 1.9e-05 25.1 7.0 4.2 4 0 0 4 4 4 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK40872.1 - 0.0092 16.3 12.6 0.0092 16.3 12.6 2.7 2 0 0 2 2 2 1 EGF-like domain Pardaxin PF07425.11 PIK40873.1 - 1 9.0 7.8 7.6 6.2 0.3 3.2 3 0 0 3 3 3 0 Pardaxin Cadherin PF00028.17 PIK40875.1 - 3.4e-74 245.4 11.9 1.7e-17 63.7 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_3 PF16184.5 PIK40875.1 - 9.2e-08 32.1 14.9 0.055 13.5 0.1 6.1 6 0 0 6 6 6 4 Cadherin-like Cadherin_2 PF08266.12 PIK40875.1 - 9.5e-07 28.6 0.0 0.044 13.6 0.0 4.3 5 0 0 5 5 5 2 Cadherin-like PS-DH PF14765.6 PIK40875.1 - 0.15 11.3 0.0 19 4.3 0.0 2.4 2 0 0 2 2 2 0 Polyketide synthase dehydratase Cadherin PF00028.17 PIK40876.1 - 7e-35 119.3 1.9 2e-15 57.0 0.2 3.1 3 0 0 3 3 3 3 Cadherin domain Cadherin_3 PF16184.5 PIK40876.1 - 1e-05 25.5 3.8 0.0023 17.9 0.3 3.1 3 0 0 3 3 3 2 Cadherin-like TagA PF12561.8 PIK40876.1 - 0.021 15.2 0.0 0.029 14.8 0.0 1.3 1 0 0 1 1 1 0 ToxR activated gene A lipoprotein domain Cadherin_4 PF17803.1 PIK40876.1 - 2.1 9.0 15.0 3.6 8.3 6.8 3.0 3 0 0 3 3 3 0 Bacterial cadherin-like domain Cadherin PF00028.17 PIK40877.1 - 1.8e-233 755.9 61.7 5.6e-19 68.4 0.3 17.3 17 0 0 17 17 17 17 Cadherin domain Cadherin_2 PF08266.12 PIK40877.1 - 2.3e-31 107.4 0.8 0.01 15.7 0.0 14.0 15 1 0 15 15 15 9 Cadherin-like Cadherin_3 PF16184.5 PIK40877.1 - 7.8e-09 35.5 50.9 5.3e-05 23.2 0.6 13.2 14 2 1 15 15 15 5 Cadherin-like RET_CLD1 PF17756.1 PIK40877.1 - 1.6e-07 31.6 0.0 37 4.6 0.0 8.1 9 1 0 9 9 9 0 RET Cadherin like domain 1 Big_9 PF17963.1 PIK40877.1 - 0.025 15.3 1.0 0.025 15.3 1.0 14.0 12 3 3 15 15 15 0 Bacterial Ig domain DUF4313 PF14190.6 PIK40877.1 - 0.1 12.6 0.6 1.2 9.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4313) PepSY PF03413.19 PIK40877.1 - 0.93 10.1 11.9 9 6.9 0.0 6.4 7 0 0 7 7 7 0 Peptidase propeptide and YPEB domain He_PIG PF05345.12 PIK40877.1 - 5.3 7.3 31.7 30 4.9 0.0 10.5 12 0 0 12 12 12 0 Putative Ig domain ADH_N PF08240.12 PIK40878.1 - 4e-24 84.6 1.8 4e-24 84.6 1.8 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK40878.1 - 2.2e-21 76.2 0.3 4.2e-21 75.3 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK40878.1 - 5.4e-06 26.1 0.1 1.8e-05 24.3 0.1 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK40878.1 - 0.019 14.3 0.2 0.034 13.5 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pep_deformylase PF01327.21 PIK40878.1 - 0.21 11.2 0.0 0.43 10.2 0.0 1.5 2 0 0 2 2 2 0 Polypeptide deformylase Gtr1_RagA PF04670.12 PIK40880.1 - 1.8e-98 328.5 1.8 2.3e-98 328.2 1.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK40880.1 - 3.9e-08 33.0 0.1 7.5e-08 32.1 0.1 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK40880.1 - 4.2e-08 33.4 0.0 1.1e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK40880.1 - 8e-08 31.9 0.1 1.5e-07 31.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK40880.1 - 5.1e-06 26.6 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK40880.1 - 0.0026 17.2 0.0 0.0044 16.5 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 PIK40880.1 - 0.009 15.6 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF815 PF05673.13 PIK40880.1 - 0.02 14.0 2.1 0.069 12.3 0.0 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 PIK40880.1 - 0.045 13.6 0.1 9.8 6.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 PIK40880.1 - 0.087 12.6 0.1 0.26 11.0 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF1202 PF06717.11 PIK40880.1 - 0.11 11.8 2.4 0.64 9.4 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1202) ABC_tran PF00005.27 PIK40880.1 - 0.15 12.5 0.1 0.41 11.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Med2 PF11214.8 PIK40880.1 - 0.78 9.9 3.4 13 6.0 0.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 Glypican PF01153.19 PIK40881.1 - 5.3e-134 448.1 0.2 6.4e-134 447.8 0.2 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 PIK40881.1 - 0.0081 16.8 0.8 0.016 15.9 0.8 1.5 1 0 0 1 1 1 1 Fz domain Serglycin PF04360.12 PIK40881.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Serglycin TGF_beta_GS PF08515.12 PIK40881.1 - 6.8 6.3 5.9 27 4.4 5.9 2.1 1 1 0 1 1 1 0 Transforming growth factor beta type I GS-motif CC2-LZ PF16516.5 PIK40882.1 - 0.023 15.0 3.0 0.023 15.0 3.0 3.0 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DASH_Dad1 PF08649.10 PIK40882.1 - 0.057 13.6 4.4 5.4 7.3 0.0 3.3 3 1 1 4 4 4 0 DASH complex subunit Dad1 GAS PF13851.6 PIK40882.1 - 1 8.6 20.7 2.9 7.2 20.7 1.8 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DnaJ PF00226.31 PIK40883.1 - 5.5e-06 26.4 0.0 8.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 PIK40883.1 - 0.00013 22.0 0.0 0.00014 21.9 0.0 1.1 1 0 0 1 1 1 1 Pam16 DUF4450 PF14614.6 PIK40883.1 - 0.0073 15.9 0.0 0.0085 15.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4450) tRNA-synt_1c PF00749.21 PIK40884.1 - 5.8e-62 209.4 0.0 9.4e-62 208.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Bcl-2 PF00452.19 PIK40885.1 - 8.2e-18 64.9 0.6 1.5e-17 64.1 0.1 1.7 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family RGS PF00615.19 PIK40885.1 - 0.022 15.0 0.8 0.097 12.9 0.1 2.4 2 1 0 2 2 2 0 Regulator of G protein signaling domain RtxA PF07634.11 PIK40887.1 - 0.27 11.8 12.2 2.2e+02 2.7 0.3 7.4 3 2 0 3 3 3 0 RtxA repeat RVT_1 PF00078.27 PIK40888.1 - 2.9e-27 95.6 0.0 2.9e-27 95.6 0.0 2.1 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK40888.1 - 1e-16 60.9 0.2 1e-16 60.9 0.2 2.4 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK40888.1 - 0.0019 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family A_deaminase_N PF08451.11 PIK40889.1 - 1.8 8.9 9.1 0.14 12.4 1.2 3.2 2 1 2 4 4 4 0 Adenosine/AMP deaminase N-terminal Lig_C PF18330.1 PIK40890.1 - 0.0054 16.7 8.5 0.0054 16.7 8.5 2.7 2 1 0 2 2 2 1 Ligase Pab1020 C-terminal region Peptidase_C23 PF05379.11 PIK40890.1 - 0.021 15.0 0.4 5 7.3 0.0 2.5 2 0 0 2 2 2 0 Carlavirus endopeptidase 2OG-Fe_Oxy_2 PF10014.9 PIK40890.1 - 0.44 10.3 0.1 0.44 10.3 0.1 3.2 3 2 0 3 3 3 0 2OG-Fe dioxygenase WD-3 PF09765.9 PIK40890.1 - 6.5 6.0 21.6 3.1 7.1 2.8 3.5 3 1 0 3 3 3 0 WD-repeat region HI0933_like PF03486.14 PIK40890.1 - 10 4.7 21.9 1.4 7.5 3.2 2.9 2 1 0 3 3 3 0 HI0933-like protein Glyco_hydro_3_C PF01915.22 PIK40891.1 - 0.66 9.9 0.0 0.66 9.9 0.0 4.8 4 1 0 4 4 4 0 Glycosyl hydrolase family 3 C-terminal domain EF-hand_7 PF13499.6 PIK40892.1 - 0.0016 18.9 0.8 1.9 9.0 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair NDUFA12 PF05071.16 PIK40893.1 - 5.9e-31 107.2 4.3 7.3e-31 106.9 4.3 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 ATP-grasp_2 PF08442.10 PIK40894.1 - 1.3e-73 246.9 0.6 2e-73 246.3 0.6 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 PIK40894.1 - 1.4e-21 76.9 0.2 2.5e-21 76.1 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 PIK40894.1 - 2.1e-10 40.4 0.7 3.6e-10 39.7 0.2 1.6 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 PIK40894.1 - 0.0019 18.0 0.8 0.0043 16.8 0.0 1.9 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Peripla_BP_3 PF13377.6 PIK40894.1 - 0.14 12.4 0.0 0.53 10.6 0.0 1.9 2 0 0 2 2 2 0 Periplasmic binding protein-like domain Myb_DNA-binding PF00249.31 PIK40895.1 - 4.2e-07 30.1 1.9 0.00025 21.2 0.0 3.7 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK40895.1 - 3.4e-06 27.2 0.8 0.00042 20.5 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain B3 PF02362.21 PIK40895.1 - 0.03 14.2 0.3 0.065 13.1 0.3 1.5 1 0 0 1 1 1 0 B3 DNA binding domain DUF5591 PF17884.1 PIK40895.1 - 0.12 12.2 0.2 0.45 10.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5591) Tup_N PF08581.10 PIK40896.1 - 0.11 12.8 0.4 0.19 12.0 0.4 1.4 1 0 0 1 1 1 0 Tup N-terminal DUF2345 PF10106.9 PIK40897.1 - 0.0052 16.7 0.0 0.23 11.3 0.0 2.1 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2345) Pox_RNA_Pol_19 PF05320.12 PIK40897.1 - 0.015 15.2 1.6 0.44 10.5 0.0 2.8 2 1 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit HECT PF00632.25 PIK40897.1 - 0.13 11.7 1.3 0.17 11.3 0.8 1.5 1 1 0 1 1 1 0 HECT-domain (ubiquitin-transferase) RTP1_C2 PF10304.9 PIK40897.1 - 0.45 10.3 22.4 21 5.0 0.3 5.6 6 0 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 2 Rep_fac_C PF08542.11 PIK40899.1 - 6.3e-19 68.2 2.0 2.6e-18 66.2 0.3 2.2 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 PIK40899.1 - 0.0005 20.4 0.4 0.00097 19.4 0.4 1.8 1 1 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta2 PF13177.6 PIK40899.1 - 0.035 13.9 0.5 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 DNA polymerase III, delta subunit DUF2096 PF09869.9 PIK40899.1 - 0.059 13.4 1.0 3.8 7.6 0.0 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) ADK PF00406.22 PIK40899.1 - 0.086 12.9 0.6 0.12 12.5 0.6 1.2 1 0 0 1 1 1 0 Adenylate kinase TPR_8 PF13181.6 PIK40899.1 - 0.092 13.0 0.1 0.26 11.6 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK40899.1 - 0.1 12.5 0.1 0.34 10.8 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M3 PF01432.20 PIK40900.1 - 1.1e-49 170.0 0.0 1e-42 147.0 0.0 2.6 1 1 1 2 2 2 2 Peptidase family M3 HTH_OrfB_IS605 PF12323.8 PIK40900.1 - 0.0011 18.4 0.7 0.0028 17.1 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain NST1 PF13945.6 PIK40900.1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Med4 PF10018.9 PIK40901.1 - 0.00014 21.6 0.1 0.00026 20.8 0.0 1.5 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 CEP19 PF14933.6 PIK40902.1 - 7.8e-48 162.9 0.5 8.8e-48 162.7 0.5 1.0 1 0 0 1 1 1 1 CEP19-like protein Tudor_FRX1 PF18336.1 PIK40903.1 - 2.1e-12 46.8 1.2 3.4e-12 46.1 0.1 1.9 2 0 0 2 2 2 1 Fragile X mental retardation Tudor domain KH_9 PF17904.1 PIK40903.1 - 6e-10 39.4 0.5 7.9e-08 32.6 0.2 2.5 1 1 1 2 2 2 1 FMRP KH0 domain Agenet PF05641.12 PIK40903.1 - 8.7e-10 38.9 1.3 3.9e-09 36.8 0.7 2.3 2 0 0 2 2 2 1 Agenet domain KH_1 PF00013.29 PIK40903.1 - 1.8e-08 34.1 1.5 4.7e-08 32.8 1.5 1.7 1 0 0 1 1 1 1 KH domain DUF4537 PF15057.6 PIK40903.1 - 0.019 15.0 0.0 0.055 13.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF5348 PF17295.2 PIK40903.1 - 0.025 14.5 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) KH_5 PF13184.6 PIK40903.1 - 0.068 13.3 2.7 0.18 11.9 1.5 2.2 2 0 0 2 2 2 0 NusA-like KH domain KH_4 PF13083.6 PIK40903.1 - 0.13 12.2 2.8 0.15 12.0 0.8 2.1 2 1 1 3 3 3 0 KH domain FXMRP1_C_core PF12235.8 PIK40904.1 - 8e-13 49.2 6.2 8e-13 49.2 6.2 2.2 1 1 1 2 2 2 2 Fragile X-related 1 protein core C terminal WD40 PF00400.32 PIK40905.1 - 2.9e-62 205.1 15.9 4.8e-10 39.9 0.2 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK40905.1 - 7.1e-18 64.7 1.7 0.0014 18.9 0.0 6.9 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK40905.1 - 3.3e-09 36.0 7.7 0.0037 16.0 0.1 6.1 1 1 5 7 7 7 3 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK40905.1 - 4.2e-08 32.9 1.1 0.05 12.9 0.0 4.6 2 2 1 4 4 4 3 WD40-like domain CEP19 PF14933.6 PIK40905.1 - 9.8e-05 22.7 0.1 0.00017 22.0 0.1 1.3 1 0 0 1 1 1 1 CEP19-like protein Ge1_WD40 PF16529.5 PIK40905.1 - 0.00021 20.4 8.5 0.4 9.6 1.1 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 PIK40905.1 - 0.0019 18.1 0.3 0.44 10.6 0.0 3.7 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF1258 PF06869.12 PIK40905.1 - 0.0088 15.6 0.1 0.03 13.8 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1258) PTEN_C2 PF10409.9 PIK40906.1 - 7.6e-15 54.9 0.0 1.4e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.31 PIK40906.1 - 0.0056 15.9 7.1 0.008 15.4 7.1 1.2 1 0 0 1 1 1 1 Ion transport protein FA_hydroxylase PF04116.13 PIK40907.1 - 9.3e-24 84.3 16.8 9.3e-24 84.3 16.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily BtrH_N PF14399.6 PIK40907.1 - 0.02 15.1 1.6 0.055 13.7 0.1 2.2 2 0 0 2 2 2 0 Butirosin biosynthesis protein H, N-terminal PhoLip_ATPase_C PF16212.5 PIK40908.1 - 9.4e-84 281.1 25.9 9.4e-84 281.1 25.9 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 PIK40908.1 - 1.8e-27 94.8 0.4 1.8e-27 94.8 0.4 2.3 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 PIK40908.1 - 9.4e-11 41.6 1.0 1.9e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 PIK40908.1 - 3e-08 34.2 1.3 0.0015 18.9 0.4 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK40908.1 - 0.0015 18.5 0.0 0.1 12.7 0.0 3.3 2 2 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 PIK40908.1 - 0.0085 15.9 0.0 0.023 14.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Fim-adh_lectin PF09222.10 PIK40908.1 - 0.11 12.0 1.1 0.21 11.1 1.1 1.4 1 0 0 1 1 1 0 Fimbrial adhesin F17-AG, lectin domain DUF5134 PF17197.4 PIK40908.1 - 7.9 6.4 9.9 4.7 7.1 7.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) YMF19 PF02326.15 PIK40908.1 - 9.2 7.1 9.3 5.3 7.9 0.3 3.9 4 0 0 4 4 4 0 Plant ATP synthase F0 Cyclin_N PF00134.23 PIK40909.1 - 2.7e-46 156.5 0.5 4.5e-46 155.7 0.5 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK40909.1 - 1.3e-31 109.2 0.1 3.3e-31 107.8 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N2 PF16500.5 PIK40909.1 - 2.3e-08 34.9 0.7 6.7e-08 33.4 0.0 2.0 1 1 1 2 2 2 1 N-terminal region of cyclin_N PDEase_I PF00233.19 PIK40910.1 - 1.1e-16 61.3 0.1 1.5e-16 60.9 0.1 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I PF00233.19 PIK40911.1 - 9e-29 100.9 7.4 1e-28 100.7 5.2 2.2 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 PIK40911.1 - 1.4e-20 74.3 0.2 8.8e-18 65.2 0.0 2.6 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.6 PIK40911.1 - 4.5e-11 43.2 0.0 1e-08 35.6 0.0 2.4 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 PIK40911.1 - 2e-07 31.4 0.0 7.7e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 GAF domain DUF1043 PF06295.12 PIK40911.1 - 0.064 13.3 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) ODR4-like PF14778.6 PIK40911.1 - 0.094 11.7 0.4 0.13 11.2 0.4 1.1 1 0 0 1 1 1 0 Olfactory receptor 4-like HD PF01966.22 PIK40911.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 HD domain MbeB_N PF04837.12 PIK40911.1 - 0.54 10.6 3.7 23 5.4 0.0 2.9 3 0 0 3 3 3 0 MbeB-like, N-term conserved region DUF1992 PF09350.10 PIK40912.1 - 8.5e-19 67.5 0.1 3.6e-18 65.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) DUF3970 PF13113.6 PIK40912.1 - 0.11 12.7 1.0 0.46 10.7 1.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3970) zf-RING_10 PF16685.5 PIK40913.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1992 PF09350.10 PIK40914.1 - 2.7e-19 69.1 0.0 8e-19 67.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DnaJ PF00226.31 PIK40914.1 - 4.7e-08 33.0 0.4 4.7e-08 33.0 0.4 2.2 2 0 0 2 2 2 1 DnaJ domain Fer2 PF00111.27 PIK40915.1 - 4e-08 33.1 0.2 7e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain SCP2 PF02036.17 PIK40916.1 - 6.4e-27 94.0 0.2 1.5e-26 92.8 0.2 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.23 PIK40916.1 - 2.1e-14 53.5 0.0 2.4e-11 43.5 0.0 2.4 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK40916.1 - 2.6e-13 49.7 0.1 2.5e-11 43.3 0.1 3.1 2 1 1 3 3 3 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.6 PIK40916.1 - 1.3e-08 35.1 0.0 3.2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 PIK40916.1 - 5.2e-06 26.8 0.0 1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Sterol carrier protein domain SpoVAD PF07451.11 PIK40916.1 - 0.00012 20.9 0.0 0.00042 19.1 0.0 1.7 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) ketoacyl-synt PF00109.26 PIK40916.1 - 0.00015 21.5 0.4 0.46 10.0 0.0 2.3 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 PIK40916.1 - 0.00092 19.0 0.1 0.02 14.8 0.1 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 PIK40916.1 - 0.0019 18.2 0.0 0.56 10.2 0.0 3.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SCP2 PF02036.17 PIK40917.1 - 3.2e-28 98.2 0.3 3.7e-28 98.0 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 PIK40917.1 - 8.8e-08 32.5 0.0 1.1e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 PIK40917.1 - 9.8e-05 22.7 0.0 0.00013 22.3 0.0 1.1 1 0 0 1 1 1 1 Sterol carrier protein domain Tctex-1 PF03645.13 PIK40918.1 - 4.5e-19 68.6 0.0 1.2e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Tctex-1 family CCDC85 PF10226.9 PIK40918.1 - 0.18 11.4 0.1 0.18 11.4 0.1 2.1 2 0 0 2 2 2 0 CCDC85 family TauD PF02668.16 PIK40919.1 - 5.7e-37 128.0 0.3 2.3e-36 126.0 0.0 1.9 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK40919.1 - 1.7e-17 63.8 1.0 5e-17 62.3 1.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF971) DUF2442 PF10387.9 PIK40919.1 - 0.00064 20.0 1.2 1.9 8.9 0.0 3.9 4 1 1 5 5 5 2 Protein of unknown function (DUF2442) CsiD PF08943.10 PIK40919.1 - 0.004 16.3 0.0 0.01 14.9 0.0 1.6 1 0 0 1 1 1 1 CsiD MIB_HERC2 PF06701.13 PIK40919.1 - 0.26 11.6 1.0 20 5.5 0.1 2.7 2 0 0 2 2 2 0 Mib_herc2 FAM198 PF15051.6 PIK40920.1 - 3.7e-39 134.5 0.1 7.3e-22 77.7 0.1 2.2 2 0 0 2 2 2 2 FAM198 protein Ndc1_Nup PF09531.10 PIK40920.1 - 1.4 7.5 5.3 1.9 7.1 5.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4746 PF15928.5 PIK40921.1 - 0.19 11.1 13.2 0.28 10.6 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 PIK40921.1 - 1.2 7.8 10.8 1.8 7.2 10.8 1.3 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 PIK40921.1 - 2.9 6.8 5.9 4.2 6.3 5.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Plasmodium_Vir PF05795.11 PIK40921.1 - 3.4 7.0 10.7 4.9 6.5 10.7 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein V_ATPase_I PF01496.19 PIK40921.1 - 4.8 5.0 5.3 6.1 4.6 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5427 PF10310.9 PIK40921.1 - 7.1 5.5 18.2 9.6 5.0 18.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ldl_recept_a PF00057.18 PIK40922.1 - 1.2e-38 131.0 102.8 1.4e-11 44.4 13.4 7.2 7 1 0 7 7 7 5 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK40922.1 - 2.8e-21 75.7 0.2 3.1e-05 24.3 0.0 4.6 4 0 0 4 4 4 4 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK40922.1 - 6.9e-09 35.8 36.8 1.6e-06 28.3 6.1 6.8 6 1 1 7 7 7 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK40922.1 - 1.6e-08 34.6 7.4 1.6e-08 34.6 7.4 8.0 4 2 1 5 5 5 1 Calcium-binding EGF domain SGL PF08450.12 PIK40922.1 - 0.00012 21.7 0.0 0.00041 20.0 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 PIK40922.1 - 0.0099 16.5 4.9 0.0099 16.5 4.9 8.4 10 1 2 12 12 12 1 Human growth factor-like EGF DUF4118 PF13493.6 PIK40923.1 - 0.82 9.5 5.0 2.9 7.7 5.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4118) MATH PF00917.26 PIK40924.1 - 5.6e-07 29.7 0.5 1.4e-06 28.4 0.2 1.7 2 0 0 2 2 2 1 MATH domain WWE PF02825.20 PIK40925.1 - 1.2e-15 57.9 3.3 2.1e-15 57.0 3.3 1.5 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.6 PIK40925.1 - 5.6e-07 29.3 12.3 9.4e-07 28.6 12.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK40925.1 - 3e-06 27.5 12.8 5.1e-06 26.7 12.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK40925.1 - 3.6e-06 26.9 12.7 9.5e-06 25.5 12.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK40925.1 - 3.5e-05 23.9 12.4 7.7e-05 22.8 12.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK40925.1 - 8.5e-05 22.3 12.6 0.00015 21.5 12.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK40925.1 - 0.00033 20.5 13.6 0.00059 19.6 13.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK40925.1 - 0.00077 19.4 12.9 0.0013 18.6 12.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK40925.1 - 0.0075 16.1 13.6 0.023 14.6 13.4 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK40925.1 - 1.3 9.3 11.3 3.7 7.9 11.3 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 PIK40925.1 - 1.7 8.9 10.5 3 8.0 10.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 HTH_Tnp_Tc5 PF03221.16 PIK40926.1 - 2.2e-10 40.4 0.0 6.8e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 PIK40926.1 - 2.1e-08 33.8 0.0 4.8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain UPF0239 PF06783.11 PIK40926.1 - 2.3 8.4 6.2 4.6 7.5 6.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) zf-H2C2_2 PF13465.6 PIK40927.1 - 2.2e-43 144.8 74.0 1.3e-07 31.7 3.9 10.4 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.26 PIK40927.1 - 9.8e-29 98.2 86.5 9.1e-05 22.7 0.8 10.3 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK40927.1 - 8.5e-21 72.9 81.5 0.0022 18.7 0.7 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK40927.1 - 5.8e-11 42.4 62.5 0.0055 17.0 0.0 8.7 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK40927.1 - 5.2e-07 29.9 66.3 0.001 19.3 3.3 9.1 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-trcl PF13451.6 PIK40927.1 - 0.0034 17.3 2.5 0.0034 17.3 2.5 7.0 8 0 0 8 8 8 1 Probable zinc-ribbon domain C1_4 PF07975.12 PIK40927.1 - 0.0072 16.5 50.9 0.24 11.7 0.7 6.6 2 1 4 7 7 7 4 TFIIH C1-like domain PyrI_C PF02748.15 PIK40927.1 - 0.0081 16.0 41.2 0.45 10.5 0.8 7.1 5 2 2 7 7 7 4 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 PIK40927.1 - 0.032 14.2 1.5 0.032 14.2 1.5 10.4 10 1 0 10 10 10 0 C2H2-type zinc finger DUF3268 PF11672.8 PIK40927.1 - 0.13 12.6 0.4 0.13 12.6 0.4 5.7 4 2 3 7 7 6 0 zinc-finger-containing domain zf-C2H2_3rep PF18868.1 PIK40927.1 - 0.55 10.9 34.1 1 10.0 2.5 6.1 3 1 1 5 5 4 0 Zinc finger C2H2-type, 3 repeats NAD_binding_1 PF00175.21 PIK40927.1 - 0.76 10.4 4.1 23 5.7 0.5 3.8 3 0 0 3 3 3 0 Oxidoreductase NAD-binding domain EIF_2_alpha PF07541.12 PIK40928.1 - 2.8e-34 117.7 0.0 9.6e-34 116.0 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 PIK40928.1 - 9.9e-17 61.1 0.5 1.9e-16 60.2 0.5 1.4 1 0 0 1 1 1 1 S1 RNA binding domain DASH_Duo1 PF08651.10 PIK40928.1 - 0.077 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 DASH complex subunit Duo1 ADH_zinc_N_2 PF13602.6 PIK40929.1 - 8.4e-16 59.2 0.1 1.2e-13 52.2 0.1 2.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 PIK40929.1 - 2.7e-14 53.2 0.0 7.4e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 PIK40929.1 - 0.051 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Laminin_G_2 PF02210.24 PIK40930.1 - 2.2e-25 89.7 0.0 2.6e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK40930.1 - 6.1e-24 84.7 0.0 7.6e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 PIK40930.1 - 1.2e-05 25.5 0.0 1.5e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.11 PIK40930.1 - 0.041 14.0 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Laminin_EGF PF00053.24 PIK40931.1 - 1.1e-165 537.7 438.3 4e-11 42.9 12.4 23.4 20 3 3 23 23 23 22 Laminin EGF domain Laminin_B PF00052.18 PIK40931.1 - 2e-25 89.3 0.0 4.2e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_I PF06008.14 PIK40931.1 - 8.7e-18 65.0 7.5 8.7e-18 65.0 7.5 3.2 2 1 1 3 3 3 2 Laminin Domain I Laminin_N PF00055.17 PIK40931.1 - 1.3e-14 54.4 0.0 1.3e-14 54.4 0.0 4.6 4 0 0 4 4 2 1 Laminin N-terminal (Domain VI) Laminin_G_2 PF02210.24 PIK40931.1 - 1.2e-11 45.3 0.0 2.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK40931.1 - 1e-07 32.3 0.0 1.6e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_II PF06009.12 PIK40931.1 - 3.7e-05 23.8 0.0 3.7e-05 23.8 0.0 5.2 2 1 3 6 6 6 1 Laminin Domain II APG17 PF04108.12 PIK40931.1 - 0.29 10.2 8.2 0.18 10.9 5.1 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 DUF1664 PF07889.12 PIK40931.1 - 0.36 10.9 9.0 18 5.4 1.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) ECH_2 PF16113.5 PIK40931.1 - 1.3 8.5 11.4 0.086 12.3 4.7 2.2 2 1 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Serine_rich PF08824.10 PIK40931.1 - 1.4 8.9 7.6 2.9 7.9 1.8 2.7 2 0 0 2 2 2 0 Serine rich protein interaction domain Sec34 PF04136.15 PIK40931.1 - 2.5 8.0 6.8 21 4.9 0.1 3.2 3 0 0 3 3 3 0 Sec34-like family DASH_Duo1 PF08651.10 PIK40931.1 - 4.4 7.1 5.0 30 4.5 0.1 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF4201 PF13870.6 PIK40931.1 - 5 6.8 7.5 3.9 7.2 2.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) F420_oxidored PF03807.17 PIK40932.1 - 1.6e-10 41.4 0.0 3.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 PIK40932.1 - 0.00069 19.8 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 PIK40932.1 - 0.034 14.0 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 Rossmann-like domain 2-oxoacid_dh PF00198.23 PIK40933.1 - 9.7e-35 120.1 0.6 1.4e-34 119.6 0.6 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 PIK40933.1 - 1.9e-12 46.8 1.8 3.4e-12 46.0 1.8 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 PIK40933.1 - 1.6e-05 24.6 3.0 9.9e-05 22.1 0.5 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 PIK40933.1 - 0.0023 17.2 0.4 0.0064 15.7 0.1 1.7 2 0 0 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 PIK40933.1 - 0.04 13.8 0.3 0.075 12.9 0.3 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_3 PF13437.6 PIK40933.1 - 0.086 13.6 1.2 0.13 13.0 0.2 1.8 2 0 0 2 2 2 0 HlyD family secretion protein RnfC_N PF13375.6 PIK40933.1 - 0.088 12.8 1.6 0.45 10.5 1.6 2.2 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain SH3_2 PF07653.17 PIK40934.1 - 4.7e-07 29.4 0.0 5.6e-05 22.7 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK40934.1 - 0.0013 18.3 0.9 0.015 14.9 0.2 2.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK40934.1 - 0.032 14.1 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain PulG PF11773.8 PIK40934.1 - 0.21 11.5 0.6 19 5.2 0.2 2.7 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin Taeniidae_ag PF05596.11 PIK40935.1 - 0.019 14.9 0.2 0.049 13.6 0.2 1.7 1 0 0 1 1 1 0 Taeniidae antigen Spc7 PF08317.11 PIK40936.1 - 2.1e-05 23.5 75.7 0.00064 18.7 21.5 3.3 1 1 2 3 3 3 2 Spc7 kinetochore protein FPP PF05911.11 PIK40936.1 - 0.0018 16.6 27.1 0.0018 16.6 27.1 3.1 1 1 2 3 3 3 1 Filament-like plant protein, long coiled-coil Fez1 PF06818.15 PIK40936.1 - 0.0043 17.5 20.5 0.0043 17.5 20.5 4.2 1 1 1 3 3 3 1 Fez1 DUF3138 PF11336.8 PIK40936.1 - 0.0045 15.7 0.7 0.0045 15.7 0.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3138) DUF812 PF05667.11 PIK40936.1 - 0.0052 15.7 69.8 0.0075 15.2 30.2 3.3 1 1 2 3 3 3 1 Protein of unknown function (DUF812) DUF4407 PF14362.6 PIK40936.1 - 0.0059 16.0 15.9 0.0059 16.0 15.9 3.8 1 1 3 4 4 4 1 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 PIK40936.1 - 0.0078 15.7 73.9 0.33 10.4 39.0 4.0 1 1 3 4 4 4 2 Golgin subfamily A member 5 Tup_N PF08581.10 PIK40936.1 - 0.0098 16.2 2.0 0.0098 16.2 2.0 7.1 2 2 5 7 7 6 3 Tup N-terminal GAS PF13851.6 PIK40936.1 - 0.098 12.0 81.2 0.055 12.8 27.9 4.5 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 PIK40936.1 - 0.13 11.9 80.3 0.057 13.1 36.6 4.0 1 1 3 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 PIK40936.1 - 0.14 12.2 45.7 0.04 14.0 8.5 4.8 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) Filament PF00038.21 PIK40936.1 - 0.18 11.4 67.4 0.076 12.6 19.7 3.4 1 1 1 3 3 3 0 Intermediate filament protein UPF0242 PF06785.11 PIK40936.1 - 0.24 11.5 76.0 0.039 14.1 26.5 4.3 2 2 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 PIK40936.1 - 0.27 10.5 63.4 0.016 14.5 5.1 5.7 2 2 2 5 5 5 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 PIK40936.1 - 0.42 10.8 76.2 0.51 10.5 15.6 5.2 2 1 3 6 6 5 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 PIK40936.1 - 0.87 9.4 64.4 0.12 12.1 2.0 7.6 4 1 3 8 8 8 0 Septum formation initiator APG6_N PF17675.1 PIK40936.1 - 1.4 9.5 87.3 0.36 11.4 6.7 5.0 1 1 4 5 5 5 0 Apg6 coiled-coil region DUF948 PF06103.11 PIK40936.1 - 2.7 8.3 34.6 1.5 9.1 0.7 6.3 4 1 2 6 6 6 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 PIK40936.1 - 2.8 8.4 49.3 0.49 10.8 1.9 7.7 7 1 2 9 9 8 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 PIK40936.1 - 6.6 6.8 85.0 0.81 9.7 8.4 6.6 2 1 5 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 PIK40936.1 - 7.4 3.9 71.8 0.0098 13.5 19.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 PIK40936.1 - 9.9 6.2 23.8 0.54 10.3 6.6 4.3 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus rve PF00665.26 PIK40938.1 - 1.7e-17 63.7 0.0 2.6e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK40938.1 - 2e-09 37.4 0.5 5.6e-09 36.0 0.5 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain Ion_trans_2 PF07885.16 PIK40939.1 - 8.8e-17 60.8 4.5 2.7e-16 59.3 1.4 2.2 2 0 0 2 2 2 1 Ion channel DUF3826 PF12875.7 PIK40939.1 - 0.13 12.4 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) TruD PF01142.18 PIK40940.1 - 2.1e-15 56.5 0.1 5.4e-11 41.9 0.2 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) TruD PF01142.18 PIK40941.1 - 4.5e-10 38.9 0.0 4.8e-05 22.4 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) RVT_1 PF00078.27 PIK40942.1 - 4.7e-23 81.9 0.1 5.5e-23 81.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NAR2 PF16974.5 PIK40943.1 - 0.09 12.2 0.7 0.16 11.4 0.7 1.3 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Condensation PF00668.20 PIK40943.1 - 0.15 10.7 0.6 0.25 10.0 0.2 1.4 1 1 0 1 1 1 0 Condensation domain LRR_8 PF13855.6 PIK40944.1 - 2.4e-15 56.0 33.2 3e-08 33.3 8.5 2.8 1 1 2 3 3 3 3 Leucine rich repeat ig PF00047.25 PIK40944.1 - 8.7e-06 25.8 0.0 2.5e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.6 PIK40944.1 - 0.00015 21.8 0.1 0.0012 18.8 0.0 2.2 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ig_3 PF13927.6 PIK40944.1 - 0.0002 21.9 0.0 0.00069 20.2 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK40944.1 - 0.00065 19.7 0.3 0.0021 18.1 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK40944.1 - 0.0068 16.7 0.1 0.021 15.2 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK40944.1 - 0.03 14.5 0.7 0.077 13.2 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin V-set domain DUF3923 PF13061.6 PIK40944.1 - 0.06 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3923) DUF2417 PF10329.9 PIK40944.1 - 0.077 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Lep_receptor_Ig PF06328.11 PIK40944.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Ig-like C2-type domain LRRCT PF01463.24 PIK40944.1 - 0.15 12.7 0.2 0.75 10.5 0.0 2.4 3 0 0 3 3 1 0 Leucine rich repeat C-terminal domain Orf78 PF06024.12 PIK40944.1 - 0.19 12.1 0.1 0.19 12.1 0.1 2.3 2 1 0 2 2 2 0 Orf78 (ac78) TMEM154 PF15102.6 PIK40944.1 - 0.43 10.5 0.0 0.43 10.5 0.0 2.5 2 1 1 3 3 3 0 TMEM154 protein family LRR_4 PF12799.7 PIK40944.1 - 0.86 10.1 16.0 0.68 10.4 2.9 3.4 1 1 4 5 5 5 0 Leucine Rich repeats (2 copies) Gal-3-0_sulfotr PF06990.11 PIK40945.1 - 2.6e-63 214.3 2.5 3.9e-63 213.7 1.7 1.5 1 1 1 2 2 2 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK40945.1 - 0.065 13.6 0.1 0.099 13.0 0.1 1.4 1 0 0 1 1 1 0 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK40946.1 - 1e-67 228.8 2.3 1.3e-67 228.4 2.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase APG6 PF04111.12 PIK40947.1 - 2.2e-69 233.0 0.0 2.5e-69 232.8 0.0 1.0 1 0 0 1 1 1 1 Apg6 BARA domain DUF2147 PF09917.9 PIK40947.1 - 0.092 13.4 0.0 0.21 12.3 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) Med1 PF10744.9 PIK40948.1 - 9.2e-26 90.8 0.5 9.2e-26 90.8 0.5 3.0 2 1 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Spt20 PF12090.8 PIK40948.1 - 0.00069 19.3 23.4 0.00069 19.3 23.4 2.1 2 0 0 2 2 2 1 Spt20 family Activator_LAG-3 PF11498.8 PIK40948.1 - 0.0054 15.8 26.4 0.01 14.9 26.4 1.4 1 0 0 1 1 1 1 Transcriptional activator LAG-3 TFIIA PF03153.13 PIK40948.1 - 4.5 7.2 40.4 0.24 11.4 32.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Avidin PF01382.17 PIK40949.1 - 9e-35 119.6 0.8 1.2e-34 119.2 0.8 1.2 1 0 0 1 1 1 1 Avidin family Ank_3 PF13606.6 PIK40950.1 - 0.02 15.4 0.0 0.48 11.1 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.30 PIK40950.1 - 0.11 12.9 0.0 30 5.3 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 PIK40950.1 - 0.17 12.3 0.0 1.9 8.9 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) EF-hand_6 PF13405.6 PIK40952.1 - 1.3e-08 34.1 0.5 1.7e-06 27.5 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 PIK40952.1 - 3.2e-08 32.6 0.6 8.2e-05 21.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK40952.1 - 6.9e-05 23.2 2.1 0.0016 18.9 0.3 3.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK40952.1 - 9.8e-05 21.7 2.7 0.003 17.0 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK40952.1 - 0.024 14.5 0.4 6.4 6.7 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair DAP PF15228.6 PIK40953.1 - 1e-27 97.2 7.3 1.2e-27 96.9 7.3 1.0 1 0 0 1 1 1 1 Death-associated protein 7tm_1 PF00001.21 PIK40954.1 - 9.7e-35 120.2 18.1 1.4e-34 119.7 18.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK40954.1 - 5.3e-12 45.9 20.9 5.3e-12 45.9 20.9 2.5 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK40954.1 - 9.4e-06 25.1 30.1 0.00013 21.4 30.1 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Exo84_C PF16528.5 PIK40954.1 - 0.027 14.3 0.2 0.044 13.6 0.2 1.2 1 0 0 1 1 1 0 Exocyst component 84 C-terminal Ank_4 PF13637.6 PIK40955.1 - 5.3e-18 65.2 0.4 1.8e-06 28.4 0.0 4.2 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK40955.1 - 6.1e-16 58.8 0.1 2.5e-08 34.4 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK40955.1 - 1.8e-15 56.8 0.4 3.5e-08 33.5 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK40955.1 - 3.7e-15 55.6 0.3 1.4e-06 28.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 PIK40955.1 - 8.5e-12 44.2 1.0 5.3e-05 23.3 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat p450 PF00067.22 PIK40958.1 - 1.9e-120 402.8 0.0 2.3e-120 402.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UDPG_MGDP_dh PF00984.19 PIK40958.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Exo_endo_phos_2 PF14529.6 PIK40959.1 - 0.0098 15.7 0.2 0.028 14.3 0.0 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase IHABP4_N PF16174.5 PIK40959.1 - 0.067 13.8 1.7 0.12 13.0 1.7 1.6 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal RVT_1 PF00078.27 PIK40960.1 - 0.0092 15.5 0.1 0.016 14.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK40961.1 - 9.2e-34 117.0 16.5 1.3e-33 116.4 16.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK40961.1 - 1.3e-08 34.6 19.2 1.8e-08 34.1 19.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V-set PF07686.17 PIK40962.1 - 1.2e-13 51.1 0.0 0.00016 21.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK40962.1 - 2e-06 28.3 0.1 0.24 12.0 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK40962.1 - 3.9e-05 23.6 0.0 0.59 10.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Sushi PF00084.20 PIK40962.1 - 0.047 14.3 1.0 0.098 13.3 0.2 2.0 2 0 0 2 2 2 0 Sushi repeat (SCR repeat) H_lectin PF09458.10 PIK40962.1 - 0.078 13.2 0.1 0.26 11.5 0.1 1.9 1 0 0 1 1 1 0 H-type lectin domain DUF1533 PF07550.11 PIK40962.1 - 0.11 12.5 2.7 0.66 9.9 0.2 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1533) DUF1410 PF07198.11 PIK40962.1 - 0.3 11.6 3.7 1.5 9.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) WSC PF01822.19 PIK40963.1 - 8.9e-11 41.8 5.4 8.9e-11 41.8 5.4 2.1 2 0 0 2 2 2 1 WSC domain Sushi PF00084.20 PIK40963.1 - 0.00038 21.0 0.5 0.00088 19.8 0.5 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Antimicrobial25 PF16839.5 PIK40963.1 - 0.012 15.7 1.8 0.018 15.1 0.0 2.1 2 0 0 2 2 2 0 Nematode antimicrobial peptide Glyco_transf_10 PF00852.19 PIK40965.1 - 1.4e-44 151.9 1.4 1.4e-44 151.9 1.4 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK40965.1 - 1.2e-09 38.6 0.1 2.3e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Nop14 PF04147.12 PIK40965.1 - 0.079 11.2 5.1 0.1 10.8 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 PIK40965.1 - 0.25 10.5 3.2 0.4 9.8 3.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 PIK40965.1 - 2.8 5.9 12.9 3.8 5.5 12.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cobalamin_bind PF01122.19 PIK40966.1 - 4.7e-25 88.1 0.1 6.7e-25 87.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein TED_complement PF07678.14 PIK40966.1 - 0.00048 19.2 0.0 0.00085 18.4 0.0 1.3 1 0 0 1 1 1 1 A-macroglobulin TED domain DUF4430 PF14478.6 PIK40966.1 - 0.0012 19.4 0.1 0.0034 18.0 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4430) SpoU_methylase PF00588.19 PIK40967.1 - 2.7e-27 95.7 0.0 6e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 PIK40967.1 - 8.3e-15 54.8 0.1 1.8e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding DNTTIP1_dimer PF18192.1 PIK40968.1 - 2e-17 63.3 0.2 3.5e-17 62.5 0.2 1.4 1 0 0 1 1 1 1 DNTTIP1 dimerisation domain Es2 PF09751.9 PIK40969.1 - 6.9e-80 269.9 13.6 6.9e-80 269.9 13.6 2.5 2 1 0 2 2 2 1 Nuclear protein Es2 La PF05383.17 PIK40969.1 - 0.0038 17.2 0.0 0.0083 16.2 0.0 1.6 1 0 0 1 1 1 1 La domain LsmAD PF06741.13 PIK40970.1 - 4.6e-09 36.7 0.4 1.1e-08 35.5 0.4 1.6 1 0 0 1 1 1 1 LsmAD domain Glyco_hydro_2_C PF02836.17 PIK40972.1 - 4.6e-78 262.4 0.0 1.2e-77 261.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 PIK40972.1 - 9.3e-20 71.2 0.1 2.1e-19 70.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 PIK40972.1 - 0.023 15.3 0.1 0.043 14.5 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 PIK40972.1 - 0.052 14.1 0.1 0.14 12.7 0.1 1.7 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Guanylate_kin PF00625.21 PIK40973.1 - 1.4e-61 207.4 0.2 2.5e-61 206.5 0.2 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 PIK40973.1 - 1.3e-57 192.0 13.1 9.3e-19 67.6 0.7 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK40973.1 - 1.2e-21 76.3 6.0 3.8e-06 26.6 0.1 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK40973.1 - 8.8e-12 45.2 2.7 0.015 15.6 0.1 3.5 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.17 PIK40973.1 - 1.5e-06 27.8 0.0 4.7e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK40973.1 - 1.5e-06 27.7 0.0 4.1e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK40973.1 - 0.032 14.1 0.1 0.13 12.1 0.1 2.1 1 0 0 1 1 1 0 Variant SH3 domain PUA PF01472.20 PIK40973.1 - 0.12 12.3 1.7 15 5.7 0.2 3.1 3 0 0 3 3 3 0 PUA domain DUF1638 PF07796.11 PIK40973.1 - 0.15 12.1 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) Tricorn_PDZ PF14685.6 PIK40973.1 - 0.35 10.9 2.1 5.2 7.1 0.0 3.5 4 0 0 4 4 4 0 Tricorn protease PDZ domain EGF PF00008.27 PIK40974.1 - 2.8e-29 101.0 94.9 4.8e-08 33.1 9.3 7.0 7 0 0 7 7 7 6 EGF-like domain hEGF PF12661.7 PIK40974.1 - 3.7e-13 49.6 66.3 0.00049 20.6 7.6 7.9 6 0 0 6 6 6 5 Human growth factor-like EGF EGF_CA PF07645.15 PIK40974.1 - 2.3e-05 24.5 94.2 0.0014 18.7 11.9 7.6 5 2 2 7 7 7 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK40974.1 - 0.00015 22.0 101.2 0.00077 19.8 10.7 7.4 7 0 0 7 7 7 5 EGF-like domain Laminin_EGF PF00053.24 PIK40974.1 - 0.08 13.1 78.2 0.22 11.7 5.5 6.7 2 2 4 6 6 6 0 Laminin EGF domain Esterase PF00756.20 PIK40975.1 - 1.1e-39 136.6 0.0 1.4e-39 136.3 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 PIK40975.1 - 3.8e-05 23.3 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 PIK40975.1 - 0.00026 20.3 0.0 0.00031 20.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 PIK40975.1 - 0.013 14.5 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 PIK40975.1 - 0.048 14.2 0.0 0.055 14.1 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 PIK40975.1 - 0.049 13.4 0.0 0.053 13.2 0.0 1.4 1 1 0 1 1 1 0 PGAP1-like protein Abhydrolase_2 PF02230.16 PIK40975.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 PIK40975.1 - 0.052 13.4 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.12 PIK40975.1 - 0.091 11.4 0.0 0.24 10.0 0.0 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Stork_head PF10264.9 PIK40976.1 - 0.12 12.6 0.1 0.41 10.8 0.1 1.9 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain TPR_2 PF07719.17 PIK40976.1 - 1.6 9.0 4.1 48 4.4 1.4 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat GSHPx PF00255.19 PIK40978.1 - 2.3e-15 56.1 0.0 3.6e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase TolA_bind_tri PF16331.5 PIK40979.1 - 0.038 14.1 1.1 0.038 14.1 1.1 5.5 4 1 2 6 6 6 0 TolA binding protein trimerisation Thioredoxin_2 PF13098.6 PIK40979.1 - 0.15 12.5 4.0 0.18 12.3 1.2 2.6 2 1 0 2 2 2 0 Thioredoxin-like domain Mss4 PF04421.13 PIK40979.1 - 0.7 10.1 5.2 1.2 9.3 0.3 3.4 3 0 0 3 3 3 0 Mss4 protein Pkinase PF00069.25 PIK40980.1 - 4.9e-77 258.9 0.0 5.6e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40980.1 - 3.4e-36 124.9 0.0 4.2e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK40980.1 - 4.1e-05 22.7 0.0 0.00025 20.1 0.1 2.2 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 PIK40980.1 - 0.00082 18.8 0.0 0.0072 15.7 0.0 2.0 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 PIK40980.1 - 0.0012 18.5 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK40980.1 - 0.0037 17.2 0.0 0.013 15.4 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Vps39_2 PF10367.9 PIK40980.1 - 0.2 12.1 0.1 0.32 11.5 0.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 La PF05383.17 PIK40981.1 - 6.7e-21 74.1 0.8 1.7e-20 72.8 0.1 2.1 2 0 0 2 2 2 1 La domain RRM_3 PF08777.11 PIK40981.1 - 7.7e-17 61.2 0.0 1.4e-15 57.2 0.2 3.9 4 0 0 4 4 4 2 RNA binding motif RRM_1 PF00076.22 PIK40981.1 - 3.6e-13 49.1 0.3 8.6e-12 44.7 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) I-set PF07679.16 PIK40982.1 - 2.4e-16 59.6 0.6 9.7e-14 51.2 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK40982.1 - 1.7e-13 51.0 0.9 4.8e-09 36.7 0.0 4.4 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK40982.1 - 1.7e-06 28.2 1.4 0.0026 18.1 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK40982.1 - 0.0003 20.9 0.1 0.022 14.9 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK40982.1 - 0.0044 17.2 1.7 0.95 9.7 0.3 3.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain EF-hand_6 PF13405.6 PIK40983.1 - 9e-07 28.3 3.2 0.00037 20.2 1.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK40983.1 - 5.2e-06 25.7 2.5 0.0065 15.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 PIK40983.1 - 1.2e-05 24.5 4.0 0.001 18.5 0.9 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 PIK40983.1 - 9.9e-05 22.6 0.2 0.00022 21.5 0.2 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 PIK40983.1 - 0.00017 21.9 8.6 0.0025 18.2 2.5 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK40983.1 - 0.00076 19.3 2.6 0.022 14.6 0.5 2.5 1 1 1 2 2 2 2 EF-hand domain pair Tnp_P_element_C PF12596.8 PIK40983.1 - 0.0061 17.1 0.7 0.025 15.1 0.0 2.1 1 1 1 2 2 2 1 87kDa Transposase SH2 PF00017.24 PIK40984.1 - 7.3e-17 61.2 1.3 1.4e-15 57.1 0.2 2.7 2 0 0 2 2 2 1 SH2 domain Pkinase PF00069.25 PIK40985.1 - 1e-50 172.6 3.8 5.9e-40 137.3 0.0 3.0 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK40985.1 - 5.4e-20 71.8 0.8 2.1e-15 56.7 0.0 3.4 1 1 1 2 2 2 2 Protein tyrosine kinase Sigma54_AID PF00309.20 PIK40985.1 - 0.051 13.4 0.1 0.051 13.4 0.1 2.8 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) APH PF01636.23 PIK40985.1 - 0.06 13.3 0.6 0.36 10.7 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Androgen_recep PF02166.16 PIK40985.1 - 1.4 7.7 9.4 2.3 7.0 9.4 1.3 1 0 0 1 1 1 0 Androgen receptor DUF1168 PF06658.12 PIK40986.1 - 0.016 15.0 14.2 0.02 14.7 14.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) AP1AR PF15745.5 PIK40986.1 - 0.028 14.0 9.5 0.032 13.9 9.5 1.0 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein DUF390 PF04094.14 PIK40986.1 - 1.4 7.1 11.0 1.4 7.1 11.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) zf-CCHC PF00098.23 PIK40988.1 - 3.4e-07 30.0 6.2 6e-05 22.9 0.4 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 PIK40988.1 - 2.4e-05 24.9 0.0 5.4e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK40988.1 - 0.0011 19.5 0.0 0.0027 18.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK40988.1 - 0.0054 17.0 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.6 PIK40988.1 - 0.37 10.5 7.9 5 6.9 0.1 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK40988.1 - 0.93 9.5 8.7 0.93 9.5 1.6 2.8 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK40988.1 - 1.2 8.9 5.2 3.6 7.4 0.4 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK40988.1 - 3.2 7.7 7.0 10 6.0 1.0 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK40988.1 - 5 7.1 12.4 0.052 13.4 3.7 2.2 2 1 1 3 3 3 0 Zinc knuckle DUF3712 PF12505.8 PIK40989.1 - 0.052 13.8 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3712) RVT_1 PF00078.27 PIK40991.1 - 6.7e-32 110.8 0.0 1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gal-3-0_sulfotr PF06990.11 PIK40992.1 - 7.3e-26 91.0 1.0 9.3e-26 90.6 1.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK40992.1 - 0.0013 19.2 0.2 0.009 16.4 0.0 2.2 1 1 1 2 2 2 1 Sulfotransferase family MFS_1 PF07690.16 PIK40993.1 - 0.0015 17.5 7.2 0.0017 17.3 7.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 PIK40994.1 - 8.7e-15 54.5 0.4 9.7e-15 54.3 0.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF543 PF04418.12 PIK40994.1 - 1.9 8.5 4.2 0.54 10.3 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF543) PITH PF06201.13 PIK40995.1 - 3.2e-20 72.9 2.8 1.6e-14 54.4 0.4 2.1 1 1 1 2 2 2 2 PITH domain TFIIE_beta PF02186.15 PIK40996.1 - 1.2e-08 35.1 2.4 1.5e-08 34.8 0.0 2.4 3 0 0 3 3 3 1 TFIIE beta subunit core domain Methyltransf_25 PF13649.6 PIK40997.1 - 2.9e-11 43.9 0.2 1.5e-10 41.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 PIK40997.1 - 2.2e-10 40.4 0.0 4.9e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK40997.1 - 5.9e-09 35.9 0.0 1.1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK40997.1 - 3e-08 34.2 0.1 1.2e-07 32.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 PIK40997.1 - 9.1e-07 28.1 0.1 1.5e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 PIK40997.1 - 1.2e-06 28.5 0.0 3.4e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK40997.1 - 1.5e-06 27.9 0.1 2.6e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 PIK40997.1 - 2.1e-05 24.5 0.1 4.2e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK40997.1 - 4.2e-05 24.2 0.6 0.00026 21.7 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain FtsJ PF01728.19 PIK40997.1 - 0.00072 19.7 0.1 0.0016 18.5 0.1 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 PIK40997.1 - 0.00072 18.9 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_16 PF10294.9 PIK40997.1 - 0.002 17.9 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase TehB PF03848.14 PIK40997.1 - 0.0024 17.3 0.1 0.0045 16.4 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 PIK40997.1 - 0.0025 17.5 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PRMT5 PF05185.16 PIK40997.1 - 0.0033 17.3 0.3 0.0073 16.2 0.0 1.7 2 0 0 2 2 1 1 PRMT5 arginine-N-methyltransferase PCMT PF01135.19 PIK40997.1 - 0.0095 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 PIK40997.1 - 0.011 15.5 0.1 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_32 PF13679.6 PIK40997.1 - 0.014 15.4 0.1 0.069 13.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 PIK40997.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase zf-C2H2_2 PF12756.7 PIK40997.1 - 0.015 15.6 1.6 0.072 13.4 1.6 2.2 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Ubie_methyltran PF01209.18 PIK40997.1 - 0.036 13.4 0.1 0.058 12.7 0.1 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 PIK40997.1 - 0.038 15.0 0.0 0.13 13.3 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain T3SS_needle_E PF08988.10 PIK40997.1 - 0.048 13.8 0.3 0.11 12.6 0.3 1.6 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle RrnaAD PF00398.20 PIK40997.1 - 0.078 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase zf-C2H2_4 PF13894.6 PIK40997.1 - 0.4 11.6 1.7 1.3 10.1 1.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger COesterase PF00135.28 PIK40998.1 - 1.1e-142 476.6 0.1 1.2e-142 476.4 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK40998.1 - 2.3e-08 34.2 3.0 9.1e-08 32.2 2.9 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK40998.1 - 7.4e-05 22.3 0.2 0.00014 21.4 0.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family NAD_binding_6 PF08030.12 PIK40999.1 - 6.3e-33 114.1 0.1 1.3e-32 113.1 0.0 1.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 PIK40999.1 - 4.1e-22 78.3 0.1 1.3e-21 76.7 0.1 1.8 1 1 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 PIK40999.1 - 3e-05 24.3 0.0 0.00019 21.7 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 PIK40999.1 - 4.3e-05 24.1 0.1 0.0041 17.7 0.1 2.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain SbsC_C PF18058.1 PIK40999.1 - 0.1 12.9 0.1 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 SbsC C-terminal domain Ras PF00071.22 PIK41000.1 - 3.5e-50 169.8 0.8 7.4e-50 168.7 0.8 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41000.1 - 5.3e-21 75.1 0.1 1.1e-20 74.1 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK41000.1 - 5.7e-11 42.2 0.6 8.9e-11 41.6 0.6 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK41000.1 - 0.0076 15.8 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain INT_SG_DDX_CT_C PF15300.6 PIK41000.1 - 0.013 15.3 0.0 47 3.9 0.0 3.3 3 0 0 3 3 3 0 INTS6/SAGE1/DDX26B/CT45 C-terminus Iso_dh PF00180.20 PIK41000.1 - 0.013 14.6 0.2 0.56 9.3 0.0 2.5 2 1 0 2 2 2 0 Isocitrate/isopropylmalate dehydrogenase Importin_rep_5 PF18816.1 PIK41000.1 - 0.026 14.8 0.2 33 4.9 0.0 3.3 3 0 0 3 3 3 0 Importin repeat SUZ PF12752.7 PIK41002.1 - 3.6e-10 40.4 4.1 3.6e-10 40.4 4.1 3.4 3 1 0 3 3 3 1 SUZ domain bZIP_2 PF07716.15 PIK41003.1 - 1.3e-13 50.8 13.0 2.2e-13 50.1 13.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK41003.1 - 4.8e-05 23.4 11.2 7.8e-05 22.7 11.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor Macoilin PF09726.9 PIK41003.1 - 0.056 12.0 5.9 0.059 11.9 5.9 1.1 1 0 0 1 1 1 0 Macoilin family VIR_N PF15912.5 PIK41003.1 - 0.37 10.3 5.9 0.48 10.0 5.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal CDC45 PF02724.14 PIK41003.1 - 0.49 8.6 10.8 0.6 8.3 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Phlebovirus_NSM PF07246.11 PIK41003.1 - 2.5 7.4 6.5 3.8 6.8 6.2 1.4 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF5505 PF17610.2 PIK41005.1 - 0.029 14.4 1.4 6.2 6.8 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5505) SPA PF08616.10 PIK41005.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis DUF3072 PF11272.8 PIK41005.1 - 0.72 9.8 6.1 0.21 11.5 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) SPX PF03105.19 PIK41005.1 - 9.1 6.1 29.2 0.11 12.3 19.1 2.2 2 0 0 2 2 2 0 SPX domain Pkinase PF00069.25 PIK41007.1 - 0.00011 21.7 0.0 0.00047 19.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41007.1 - 0.0026 17.1 0.0 0.0052 16.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PA28_beta PF02252.18 PIK41007.1 - 0.08 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit DUF1764 PF08576.10 PIK41007.1 - 3.6 8.6 10.0 13 6.7 0.4 2.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Ribosomal_L5e PF17144.4 PIK41008.1 - 1.3e-88 295.2 0.2 1.3e-88 295.2 0.2 1.6 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 PIK41008.1 - 2.1e-37 127.9 2.6 2.1e-37 127.9 2.6 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region K_oxygenase PF13434.6 PIK41008.1 - 0.15 11.2 2.0 0.23 10.6 0.8 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FPP PF05911.11 PIK41009.1 - 0.00017 20.0 30.4 0.00017 20.0 30.4 9.5 2 2 5 8 8 8 4 Filament-like plant protein, long coiled-coil Fez1 PF06818.15 PIK41009.1 - 0.0057 17.1 31.0 0.0057 17.1 31.0 11.1 2 1 11 13 13 13 5 Fez1 SURF1 PF02104.15 PIK41010.1 - 3.1e-39 135.0 0.1 3.3e-39 134.9 0.1 1.1 1 0 0 1 1 1 1 SURF1 family Prefoldin_2 PF01920.20 PIK41011.1 - 3e-22 78.6 14.9 4.1e-22 78.1 14.9 1.2 1 0 0 1 1 1 1 Prefoldin subunit ADIP PF11559.8 PIK41011.1 - 0.0017 18.4 2.6 0.0017 18.4 2.6 2.0 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 PIK41011.1 - 0.0018 18.3 3.2 0.0018 18.3 3.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Cas_Cas6 PF01881.16 PIK41011.1 - 0.0024 18.4 1.8 0.0027 18.2 1.3 1.4 1 1 0 1 1 1 1 CRISPR associated protein Cas6 XhlA PF10779.9 PIK41011.1 - 0.0054 16.9 1.7 0.0054 16.9 1.7 2.4 2 1 0 2 2 2 1 Haemolysin XhlA Prefoldin PF02996.17 PIK41011.1 - 0.046 13.6 13.8 1.2 9.0 13.8 2.5 1 1 0 1 1 1 0 Prefoldin subunit Snapin_Pallidin PF14712.6 PIK41011.1 - 0.052 14.0 3.7 0.052 14.0 3.7 2.5 1 1 1 2 2 2 0 Snapin/Pallidin DUF1464 PF07318.12 PIK41011.1 - 0.16 11.1 1.1 0.18 11.0 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Cluap1 PF10234.9 PIK41011.1 - 0.16 11.3 12.0 0.22 10.9 12.0 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF3584 PF12128.8 PIK41011.1 - 0.17 9.4 15.2 0.2 9.2 15.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Wtap PF17098.5 PIK41011.1 - 0.29 11.1 9.5 0.78 9.7 9.5 1.7 1 1 0 1 1 1 0 WTAP/Mum2p family Fib_alpha PF08702.10 PIK41011.1 - 0.3 11.2 9.5 0.87 9.8 9.5 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 PIK41011.1 - 0.35 11.2 10.7 0.15 12.4 2.5 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ABC_tran_CTD PF16326.5 PIK41011.1 - 1.1 9.5 15.1 0.15 12.3 2.4 2.8 2 1 1 3 3 3 0 ABC transporter C-terminal domain KxDL PF10241.9 PIK41011.1 - 1.2 9.5 13.5 0.19 12.0 5.4 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF4407 PF14362.6 PIK41011.1 - 1.3 8.3 9.4 1.9 7.8 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nup88 PF10168.9 PIK41011.1 - 1.6 6.4 12.9 2.1 6.1 12.9 1.2 1 1 0 1 1 1 0 Nuclear pore component FlaC_arch PF05377.11 PIK41011.1 - 3.1 8.3 7.2 0.67 10.4 0.3 2.9 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Syntaxin_2 PF14523.6 PIK41011.1 - 4.5 7.7 15.4 1.1 9.7 6.3 2.3 1 1 1 2 2 2 0 Syntaxin-like protein Occludin_ELL PF07303.13 PIK41011.1 - 5.2 7.9 12.8 6.4e+02 1.2 12.8 2.2 1 1 0 1 1 1 0 Occludin homology domain IZUMO PF15005.6 PIK41011.1 - 5.9 7.4 8.6 17 5.9 8.5 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF4795 PF16043.5 PIK41011.1 - 6.5 6.3 16.3 11 5.6 15.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) PRKCSH-like PF12999.7 PIK41011.1 - 7.9 6.2 10.0 0.76 9.6 3.7 1.9 1 1 1 2 2 2 0 Glucosidase II beta subunit-like BRE1 PF08647.11 PIK41011.1 - 9.2 6.4 20.2 2.9 8.0 6.3 2.7 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Acyl_transf_1 PF00698.21 PIK41012.1 - 5.6e-34 118.1 0.0 7.6e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 PIK41012.1 - 4.5e-30 105.1 0.0 8.6e-30 104.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 PIK41012.1 - 8.1e-15 55.2 0.0 1.3e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Ketoacyl-synt_C PF02801.22 PIK41012.1 - 1.6e-14 53.9 0.0 1.7e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.26 PIK41013.1 - 0.017 15.1 0.2 0.041 13.9 0.1 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase HVSL PF09749.9 PIK41013.1 - 0.024 14.1 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein KR PF08659.10 PIK41014.1 - 5.9e-10 39.3 0.0 1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 PIK41014.1 - 2.3e-07 31.1 0.1 4.8e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 PIK41014.1 - 0.074 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase FMO-like PF00743.19 PIK41015.1 - 3.2e-158 527.4 0.0 3.9e-158 527.2 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK41015.1 - 8.1e-20 71.3 0.0 5e-16 58.8 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK41015.1 - 1.5e-13 50.7 0.0 6.2e-13 48.6 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK41015.1 - 3.3e-08 33.1 0.1 5.5e-07 29.1 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK41015.1 - 3.7e-05 23.9 0.0 8.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK41015.1 - 0.0047 16.2 0.0 0.74 9.0 0.0 2.5 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 PIK41015.1 - 0.02 15.4 3.8 0.12 12.9 0.0 3.5 5 0 0 5 5 5 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK41015.1 - 0.12 11.0 0.0 0.9 8.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 PIK41015.1 - 0.15 11.3 0.0 6 6.1 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 PIK41016.1 - 9e-83 278.5 0.0 1.1e-82 278.2 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK41016.1 - 2.2e-19 69.9 0.0 2.8e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK41016.1 - 1.4e-11 44.2 0.8 2.1e-10 40.3 0.1 2.0 1 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 PIK41016.1 - 9.2e-11 41.5 0.0 1.2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK41016.1 - 1e-06 28.8 0.0 2.5e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 PIK41016.1 - 1.5e-05 25.4 1.0 0.48 11.0 0.1 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK41016.1 - 1.7e-05 24.6 0.1 0.0052 16.4 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK41016.1 - 4.7e-05 23.4 0.0 0.0028 17.7 0.0 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 PIK41016.1 - 0.0052 15.5 0.2 0.065 11.9 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 PIK41016.1 - 0.0075 15.5 0.1 0.034 13.4 0.0 1.9 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 PIK41016.1 - 0.011 15.0 0.1 2.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 PIK41016.1 - 0.06 12.6 0.1 2.3 7.4 0.0 2.1 1 1 1 2 2 2 0 FAD binding domain Peptidase_M17_N PF02789.17 PIK41016.1 - 0.13 12.1 0.1 0.55 10.1 0.0 1.8 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain NAD_binding_7 PF13241.6 PIK41016.1 - 0.15 12.5 0.4 28 5.2 0.1 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 PIK41016.1 - 0.19 11.8 0.0 6.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FMO-like PF00743.19 PIK41017.1 - 3e-154 514.4 0.0 3.6e-154 514.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK41017.1 - 9.9e-24 84.1 0.1 4.1e-20 72.3 0.0 2.8 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK41017.1 - 7.1e-13 48.4 0.1 1.5e-08 34.2 0.0 3.2 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 PIK41017.1 - 9.2e-12 44.8 0.0 2.2e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK41017.1 - 9.8e-07 28.9 0.0 2.7e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK41017.1 - 6.9e-06 25.9 0.0 0.11 12.1 0.0 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK41017.1 - 0.00032 19.9 0.0 0.0019 17.4 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 PIK41017.1 - 0.0023 17.2 0.1 0.0091 15.3 0.0 1.9 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 PIK41017.1 - 0.0029 17.0 0.0 0.57 9.4 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 PIK41017.1 - 0.0041 16.5 0.0 0.0097 15.3 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK41017.1 - 0.0042 17.6 0.5 0.47 11.0 0.0 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK41017.1 - 0.0076 15.0 0.2 0.046 12.4 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 PIK41017.1 - 0.0099 15.2 0.0 0.025 13.9 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 PIK41017.1 - 0.011 15.7 0.3 12 5.9 0.0 3.3 4 0 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 PIK41017.1 - 0.023 13.9 0.2 0.07 12.4 0.1 1.7 1 1 1 2 2 2 0 FAD binding domain Speriolin_C PF15059.6 PIK41018.1 - 0.0099 16.0 6.0 55 3.9 0.0 5.6 5 2 1 6 6 6 2 Speriolin C-terminus TAFA PF12020.8 PIK41018.1 - 6.9 7.2 16.5 75 3.9 0.1 6.5 5 1 1 6 6 6 0 TAFA family Kazal_1 PF00050.21 PIK41019.1 - 0.00084 19.3 2.8 0.0012 18.8 1.5 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK41019.1 - 0.0047 17.0 2.9 0.0063 16.6 1.7 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain zf-RING_6 PF14835.6 PIK41019.1 - 0.081 12.8 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF2678 PF10856.8 PIK41020.1 - 4.1e-30 104.1 1.7 4.6e-30 104.0 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) DUF5360 PF17314.2 PIK41020.1 - 0.00041 20.4 1.1 0.00053 20.1 1.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5360) BaxI_1 PF12811.7 PIK41020.1 - 0.027 14.0 1.4 0.047 13.3 1.5 1.4 1 1 0 1 1 1 0 Bax inhibitor 1 like zf-HC5HC2H_2 PF13832.6 PIK41021.1 - 3.5e-37 126.9 4.7 3.5e-37 126.9 4.7 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 PIK41021.1 - 2.7e-26 91.6 2.1 2.7e-26 91.6 2.1 3.2 3 0 0 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.9 PIK41021.1 - 1.9e-24 86.8 6.0 1.9e-24 86.8 6.0 4.3 4 1 0 4 4 4 1 Enhancer of polycomb-like Bromodomain PF00439.25 PIK41021.1 - 1.3e-22 79.6 0.2 3.3e-22 78.3 0.2 1.7 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.17 PIK41021.1 - 3.4e-15 56.2 0.0 3.4e-15 56.2 0.0 2.6 3 0 0 3 3 3 1 PWWP domain PHD_2 PF13831.6 PIK41021.1 - 1e-14 53.8 3.2 1e-14 53.8 3.2 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 PIK41021.1 - 6.4e-08 32.4 27.1 3.4e-07 30.1 12.5 2.7 2 0 0 2 2 2 2 PHD-finger Vps39_1 PF10366.9 PIK41021.1 - 0.023 15.0 0.2 0.062 13.6 0.2 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 Phage_TAC_4 PF08748.11 PIK41022.1 - 0.013 15.8 0.1 0.087 13.1 0.0 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone DUF4619 PF15398.6 PIK41022.1 - 0.022 14.3 0.1 0.022 14.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4619) Katanin_con80 PF13925.6 PIK41024.1 - 0.00013 22.1 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 con80 domain of Katanin CytochromB561_N PF09786.9 PIK41025.1 - 3.4e-83 280.6 0.8 4.2e-83 280.3 0.8 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal LRR_6 PF13516.6 PIK41026.1 - 9.6e-10 37.7 19.2 0.019 15.0 0.0 6.6 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 PIK41026.1 - 0.0035 17.1 8.2 0.057 13.2 0.4 3.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK41026.1 - 0.029 14.8 4.2 4.1 8.0 0.0 4.1 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK41026.1 - 1.1 10.1 13.7 32 5.6 0.0 6.4 6 1 0 6 6 6 0 Leucine Rich Repeat Lebercilin PF15619.6 PIK41026.1 - 1.2 8.7 96.6 0.059 13.0 35.2 3.7 2 1 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Pur_DNA_glyco PF02245.16 PIK41027.1 - 3.1e-56 189.6 0.0 3.8e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) PEGA PF08308.11 PIK41028.1 - 2.4e-05 24.1 2.3 55 3.7 0.0 6.4 7 0 0 7 7 7 0 PEGA domain MULE PF10551.9 PIK41028.1 - 0.0041 17.5 0.0 0.01 16.2 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain SWIM PF04434.17 PIK41028.1 - 0.12 12.1 4.0 0.3 10.8 4.0 1.6 1 0 0 1 1 1 0 SWIM zinc finger PRA-CH PF01502.18 PIK41028.1 - 1.1 9.1 11.2 1.9e+02 2.0 0.1 6.2 1 1 5 6 6 6 0 Phosphoribosyl-AMP cyclohydrolase Pkinase PF00069.25 PIK41029.1 - 9.6e-10 38.3 0.1 1.6e-09 37.6 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41029.1 - 2.2e-07 30.4 0.0 3.4e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 PIK41029.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MAM PF00629.23 PIK41030.1 - 3.5e-35 121.3 0.0 2.4e-28 99.1 0.0 2.0 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu SRCR PF00530.18 PIK41031.1 - 1.6e-59 198.6 5.4 6e-30 103.7 0.7 2.4 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain MAM PF00629.23 PIK41031.1 - 2.6e-36 125.0 0.0 3.7e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu SRCR_2 PF15494.6 PIK41031.1 - 1e-12 48.5 1.5 1.5e-05 25.5 0.1 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK41031.1 - 3.7e-06 27.4 0.1 0.047 14.2 0.0 2.5 2 0 0 2 2 2 2 Hepsin, SRCR domain His_Phos_2 PF00328.22 PIK41032.1 - 8.6e-12 45.1 0.0 1.1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) SIR2 PF02146.17 PIK41034.1 - 2.3e-61 206.8 0.0 3.8e-61 206.1 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 PIK41034.1 - 0.0009 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 PIK41034.1 - 0.22 11.2 0.0 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain AAA PF00004.29 PIK41035.1 - 2.8e-36 124.8 0.0 4.6e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK41035.1 - 2e-10 40.3 0.0 4.4e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 PIK41035.1 - 1.5e-06 28.7 0.0 0.00075 19.9 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK41035.1 - 5.4e-06 26.7 0.5 0.0016 18.7 0.2 2.8 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.12 PIK41035.1 - 6.5e-06 26.0 0.0 1.7e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK41035.1 - 2e-05 24.6 0.2 0.00046 20.2 0.2 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 PIK41035.1 - 9.2e-05 22.5 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 PIK41035.1 - 0.00012 21.6 0.0 0.14 11.6 0.0 2.7 1 1 1 2 2 2 2 Bacterial TniB protein IstB_IS21 PF01695.17 PIK41035.1 - 0.00042 20.1 0.0 0.0012 18.7 0.0 1.9 2 0 0 2 2 1 1 IstB-like ATP binding protein NACHT PF05729.12 PIK41035.1 - 0.00076 19.4 0.1 0.0021 18.0 0.1 1.9 1 1 0 1 1 1 1 NACHT domain Mg_chelatase PF01078.21 PIK41035.1 - 0.00078 18.9 0.1 0.0022 17.4 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK41035.1 - 0.00097 19.5 0.1 0.0033 17.8 0.0 2.1 2 1 0 2 2 1 1 RNA helicase AAA_25 PF13481.6 PIK41035.1 - 0.0019 17.8 0.0 0.087 12.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK41035.1 - 0.0035 17.5 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 PIK41035.1 - 0.0036 17.0 0.0 0.0067 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK41035.1 - 0.0056 17.2 0.0 0.025 15.1 0.0 2.2 3 0 0 3 3 1 1 AAA domain TIP49 PF06068.13 PIK41035.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 PIK41035.1 - 0.017 15.1 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 PIK41035.1 - 0.019 14.0 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_33 PF13671.6 PIK41035.1 - 0.024 14.8 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 PIK41035.1 - 0.025 14.4 0.1 1.5 8.5 0.1 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 PIK41035.1 - 0.025 13.7 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 PIK41035.1 - 0.04 14.4 0.2 0.14 12.7 0.1 2.2 2 1 0 2 2 1 0 ABC transporter ATPase PF06745.13 PIK41035.1 - 0.043 13.2 0.2 2.5 7.4 0.0 2.4 1 1 1 2 2 2 0 KaiC AAA_28 PF13521.6 PIK41035.1 - 0.045 14.0 0.0 0.092 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK41035.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 PIK41035.1 - 0.097 13.1 1.2 0.2 12.1 0.0 2.1 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 PIK41035.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK41035.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 PIK41035.1 - 0.12 12.3 0.1 0.3 11.0 0.1 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain Treacle PF03546.14 PIK41036.1 - 1.7e-20 73.4 386.2 0.033 13.0 13.9 21.5 1 1 18 19 19 19 18 Treacher Collins syndrome protein Treacle SRP40_C PF05022.12 PIK41036.1 - 5.3e-07 30.4 0.2 2.3e-06 28.3 0.2 2.2 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.11 PIK41036.1 - 0.21 11.6 0.2 0.4 10.7 0.2 1.4 1 0 0 1 1 1 0 LisH DUF4201 PF13870.6 PIK41037.1 - 0.0013 18.5 7.0 0.0014 18.4 7.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) ADIP PF11559.8 PIK41037.1 - 0.005 16.9 7.0 0.0059 16.7 7.0 1.0 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding SlyX PF04102.12 PIK41037.1 - 0.039 14.6 10.5 0.054 14.1 4.5 2.1 1 1 1 2 2 2 0 SlyX CemA PF03040.14 PIK41037.1 - 0.094 12.6 1.7 0.1 12.5 1.7 1.0 1 0 0 1 1 1 0 CemA family XkdW PF09636.10 PIK41037.1 - 0.14 12.2 4.7 0.23 11.6 4.8 1.3 1 1 0 1 1 1 0 XkdW protein BST2 PF16716.5 PIK41037.1 - 0.31 11.6 11.6 0.05 14.2 4.4 2.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 CorA PF01544.18 PIK41037.1 - 0.32 10.3 4.5 0.34 10.2 4.5 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1640 PF07798.11 PIK41037.1 - 0.41 10.7 9.8 0.18 11.9 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DivIC PF04977.15 PIK41037.1 - 1.2 9.0 11.8 0.4 10.5 7.7 1.9 1 1 1 2 2 2 0 Septum formation initiator FAM76 PF16046.5 PIK41037.1 - 1.9 7.8 5.8 2.1 7.7 5.8 1.0 1 0 0 1 1 1 0 FAM76 protein DUF2721 PF11026.8 PIK41037.1 - 2.3 8.1 6.2 6 6.8 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF4404 PF14357.6 PIK41037.1 - 3.4 8.4 12.1 4.8 7.9 12.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) RhoGAP PF00620.27 PIK41038.1 - 2.5e-40 137.8 0.0 4.5e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 PIK41038.1 - 2.4e-07 31.2 0.0 7.7e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 PH domain PGM_PMM_II PF02879.16 PIK41039.1 - 0.18 12.5 0.0 0.68 10.6 0.0 2.0 2 1 1 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II zf_Hakai PF18408.1 PIK41040.1 - 8.4 6.2 6.0 29 4.5 2.0 2.2 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain CIMR PF00878.18 PIK41042.1 - 5.1e-06 26.6 4.9 4e-05 23.7 1.1 2.0 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 PIK41042.1 - 0.00032 19.9 0.4 0.00039 19.6 0.4 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor GpcrRhopsn4 PF10192.9 PIK41043.1 - 1.6e-27 96.5 12.2 1.6e-25 90.0 11.4 2.9 1 1 1 2 2 2 2 Rhodopsin-like GPCR transmembrane domain DUF2625 PF10946.8 PIK41043.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 Tetraspanin PF00335.20 PIK41043.1 - 2.3 7.9 7.9 0.77 9.4 3.0 2.1 2 0 0 2 2 2 0 Tetraspanin family CAP_N PF01213.19 PIK41044.1 - 4.8 6.6 14.3 3.3 7.1 13.0 1.4 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PH PF00169.29 PIK41045.1 - 1.3e-08 35.3 0.4 1.3e-08 35.3 0.4 1.9 2 0 0 2 2 2 1 PH domain RA PF00788.23 PIK41045.1 - 2e-07 31.6 0.8 3.7e-07 30.7 0.1 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain ORC6 PF05460.13 PIK41046.1 - 1.1 8.4 10.6 1.2 8.3 10.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Spindle_Spc25 PF08234.12 PIK41047.1 - 2e-24 85.6 0.7 3e-24 85.0 0.7 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 EMP24_GP25L PF01105.24 PIK41047.1 - 0.005 16.8 0.6 0.0061 16.5 0.6 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Antig_Caf1 PF09255.10 PIK41047.1 - 0.087 12.9 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Caf1 Capsule antigen PA28_beta PF02252.18 PIK41048.1 - 2e-59 199.5 0.1 2.4e-59 199.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit Fibrinogen_C PF00147.18 PIK41049.1 - 1e-56 192.2 7.9 1.2e-56 192.0 7.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK41049.1 - 0.65 9.9 2.8 1.1 9.1 2.8 1.3 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) efThoc1 PF11957.8 PIK41050.1 - 2.8e-21 75.8 3.7 6.9e-21 74.5 0.1 2.1 1 1 1 2 2 2 2 THO complex subunit 1 transcription elongation factor Death PF00531.22 PIK41050.1 - 1.2e-13 51.0 0.2 2.9e-13 49.8 0.2 1.7 1 0 0 1 1 1 1 Death domain efThoc1 PF11957.8 PIK41051.1 - 1.4e-102 343.9 16.9 1.7e-102 343.6 16.3 1.4 1 1 1 2 2 2 1 THO complex subunit 1 transcription elongation factor Glyco_hydro_67N PF03648.14 PIK41056.1 - 1.1 9.5 7.5 0.49 10.7 1.5 2.6 2 2 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus NosL PF05573.12 PIK41058.1 - 1.1e-05 25.8 11.1 1.7e+02 2.5 0.0 8.9 9 0 0 9 9 9 0 NosL CutC PF03932.14 PIK41058.1 - 1.5e-05 24.6 12.7 18 4.7 0.1 7.4 2 2 5 7 7 7 6 CutC family Acetyltransf_18 PF18014.1 PIK41059.1 - 3.3e-17 62.5 0.0 1.1e-15 57.6 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 PIK41059.1 - 4.9e-08 33.0 0.0 1.2e-07 31.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK41059.1 - 0.0002 21.5 0.0 0.0062 16.8 0.0 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family NmrA PF05368.13 PIK41059.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family YEATS PF03366.16 PIK41062.1 - 1.1e-25 89.4 0.5 1.1e-25 89.4 0.5 1.7 2 0 0 2 2 2 1 YEATS family DUF3114 PF11311.8 PIK41062.1 - 0.033 13.7 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) PhetRS_B1 PF18262.1 PIK41062.1 - 0.12 12.6 0.4 14 5.9 0.0 2.7 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain QWRF PF04484.12 PIK41062.1 - 3.1 7.5 6.4 4.5 6.9 0.2 2.2 2 0 0 2 2 2 0 QWRF family Ribosomal_L13 PF00572.18 PIK41063.1 - 7.2e-26 90.9 0.0 9.8e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 DHC_N2 PF08393.13 PIK41063.1 - 0.031 13.4 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 DUF3481 PF11980.8 PIK41064.1 - 0.14 11.8 0.7 0.34 10.6 0.7 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein ATP1G1_PLM_MAT8 PF02038.16 PIK41064.1 - 0.58 9.6 3.3 0.99 8.9 3.3 1.3 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family TMEM154 PF15102.6 PIK41065.1 - 5.3 6.9 10.1 0.56 10.1 3.9 2.5 2 1 0 2 2 2 0 TMEM154 protein family W2 PF02020.18 PIK41067.1 - 2.5e-19 69.2 5.4 2.5e-19 69.2 5.4 3.2 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon DUF4790 PF16037.5 PIK41067.1 - 0.2 12.1 0.3 0.2 12.1 0.3 2.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4790) DUF4653 PF15546.6 PIK41068.1 - 0.027 14.1 1.8 0.13 11.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4653) TFIIF_beta_N PF17683.1 PIK41068.1 - 0.061 14.0 0.1 0.097 13.4 0.1 1.4 1 1 0 1 1 1 0 TFIIF, beta subunit N-terminus DUF4555 PF15093.6 PIK41069.1 - 2.7e-37 128.6 3.4 4.7e-37 127.8 3.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4555) RabGAP-TBC PF00566.18 PIK41070.1 - 2.9e-27 95.8 10.3 5.3e-15 55.7 2.9 2.9 2 1 0 2 2 2 2 Rab-GTPase-TBC domain SEEK1 PF15357.6 PIK41070.1 - 0.021 15.0 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 GDNF PF02351.16 PIK41072.1 - 1.7e-11 44.9 47.0 1.9e-06 28.7 7.8 5.3 3 2 2 5 5 5 3 GDNF/GAS1 domain NACHT PF05729.12 PIK41073.1 - 1.3e-13 51.2 0.1 2.7e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK41073.1 - 0.078 12.6 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain CobA_CobO_BtuR PF02572.15 PIK41073.1 - 0.16 12.2 0.1 0.48 10.7 0.1 1.8 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP F5_F8_type_C PF00754.25 PIK41074.1 - 2e-28 99.1 0.0 2.3e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain F5_F8_type_C PF00754.25 PIK41075.1 - 2.2e-27 95.7 0.0 2.6e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain Cupin_8 PF13621.6 PIK41077.1 - 2e-34 119.5 0.2 2.2e-34 119.3 0.2 1.0 1 0 0 1 1 1 1 Cupin-like domain BTB_2 PF02214.22 PIK41079.1 - 3.1e-15 56.3 0.1 8.6e-15 54.9 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain SH2 PF00017.24 PIK41080.1 - 1.8e-27 95.2 0.2 7.1e-13 48.5 0.0 2.3 2 0 0 2 2 2 2 SH2 domain Myosin_head PF00063.21 PIK41081.1 - 1.9e-151 505.6 24.8 1.7e-121 406.6 0.8 4.2 4 1 1 5 5 5 3 Myosin head (motor domain) SH2 PF00017.24 PIK41081.1 - 1.4e-14 53.9 0.2 5.5e-14 52.0 0.2 2.1 1 0 0 1 1 1 1 SH2 domain AAA_22 PF13401.6 PIK41081.1 - 0.0013 19.0 0.6 0.0099 16.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain SH2_2 PF14633.6 PIK41081.1 - 0.0014 18.1 1.0 0.0033 16.8 1.0 1.6 1 0 0 1 1 1 1 SH2 domain ABC_tran PF00005.27 PIK41081.1 - 0.0047 17.4 0.2 0.025 15.1 0.1 2.2 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 PIK41081.1 - 0.021 15.2 0.0 0.077 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain IQ PF00612.27 PIK41081.1 - 0.092 12.6 0.8 0.22 11.4 0.8 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF3292 PF11696.8 PIK41081.1 - 2.1 6.6 5.1 3.2 6.0 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Cadherin_3 PF16184.5 PIK41082.1 - 1.6e-24 86.0 3.0 7.6e-08 32.3 0.0 3.3 2 1 1 3 3 3 3 Cadherin-like ELL PF10390.9 PIK41083.1 - 1.5e-64 218.2 1.2 1.5e-64 218.2 1.2 1.7 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 PIK41083.1 - 9.4e-21 74.4 10.7 9.4e-21 74.4 10.7 2.4 3 0 0 3 3 3 1 Occludin homology domain EST1_DNA_bind PF10373.9 PIK41084.1 - 2.1e-35 122.6 0.6 9.1e-34 117.2 0.0 2.7 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain EST1 PF10374.9 PIK41084.1 - 4.3e-21 76.0 0.3 4.3e-21 76.0 0.3 3.3 2 1 0 2 2 2 1 Telomerase activating protein Est1 PIN_4 PF13638.6 PIK41084.1 - 5.3e-05 23.5 2.0 0.00011 22.5 0.1 2.6 2 0 0 2 2 2 1 PIN domain DUF787 PF05619.11 PIK41084.1 - 0.0069 15.6 1.3 0.039 13.1 0.2 2.4 2 0 0 2 2 2 1 Borrelia burgdorferi protein of unknown function (DUF787) tRNA_NucTransf2 PF09249.11 PIK41084.1 - 0.11 12.8 0.2 0.29 11.4 0.2 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain PP2C_C PF07830.13 PIK41084.1 - 0.42 11.1 5.1 1.8 9.1 0.1 3.3 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Ribosomal_S17e PF00833.18 PIK41085.1 - 3.6e-62 207.7 1.6 5.3e-62 207.2 1.6 1.2 1 0 0 1 1 1 1 Ribosomal S17 TLE_N PF03920.15 PIK41086.1 - 1.8e-21 76.6 0.0 2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain Tmemb_170 PF10190.9 PIK41086.1 - 0.05 14.0 0.1 0.057 13.8 0.1 1.1 1 0 0 1 1 1 0 Putative transmembrane protein 170 DUF2475 PF10629.9 PIK41087.1 - 1.5e-15 57.1 2.2 1.3e-06 28.5 1.4 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) Meckelin PF09773.9 PIK41087.1 - 0.091 10.8 0.0 0.11 10.6 0.0 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) adh_short_C2 PF13561.6 PIK41088.1 - 2.4e-09 37.1 0.1 3.1e-09 36.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK41088.1 - 1.4e-07 31.2 0.1 1.8e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase T3SS_NleG PF06416.12 PIK41088.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Effector protein NleG UCR_TM PF02921.14 PIK41088.1 - 0.045 14.2 0.1 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region zf-MYND PF01753.18 PIK41089.1 - 1.5e-05 25.0 10.1 1.5e-05 25.0 10.1 1.8 2 0 0 2 2 2 1 MYND finger DUF997 PF06196.12 PIK41089.1 - 0.00083 19.3 0.6 0.0017 18.3 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF997) EphA2_TM PF14575.6 PIK41089.1 - 0.082 13.8 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 PIK41089.1 - 0.14 12.1 3.2 0.28 11.1 3.2 1.5 1 0 0 1 1 1 0 Syndecan domain DUF2207 PF09972.9 PIK41089.1 - 0.16 10.7 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) G8 PF10162.9 PIK41091.1 - 3.6e-28 98.1 0.0 7.5e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 PIK41091.1 - 2.2e-08 34.1 1.4 7.3e-08 32.4 1.4 1.9 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 PIK41091.1 - 0.043 13.1 0.2 0.57 9.4 0.0 2.2 1 1 1 2 2 2 0 Periplasmic copper-binding protein (NosD) RVT_1 PF00078.27 PIK41092.1 - 3.9e-32 111.6 0.0 5.6e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK41093.1 - 6.4e-30 103.2 0.0 5.4e-29 100.2 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK41093.1 - 4.1e-27 94.5 0.0 1.3e-26 92.9 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK41093.1 - 1.4e-15 57.5 0.0 3.7e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK41093.1 - 0.005 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain PTN_MK_C PF01091.18 PIK41093.1 - 0.034 14.5 0.2 0.087 13.2 0.2 1.6 1 0 0 1 1 1 0 PTN/MK heparin-binding protein family, C-terminal domain TIG PF01833.24 PIK41094.1 - 1.1e-133 435.7 83.1 1.3e-15 57.2 1.6 12.9 12 0 0 12 12 12 12 IPT/TIG domain G8 PF10162.9 PIK41094.1 - 3.6e-38 130.4 0.1 1.2e-37 128.7 0.1 2.0 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 PIK41094.1 - 0.0037 17.1 1.7 0.0037 17.1 1.7 5.0 5 0 0 5 5 5 1 Right handed beta helix region Qn_am_d_aIII PF09099.10 PIK41094.1 - 1.1 9.6 7.4 4.2 7.8 1.6 4.0 5 0 0 5 5 5 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Pkinase_Tyr PF07714.17 PIK41095.1 - 8.2e-66 221.9 0.1 1.2e-52 178.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase I-set PF07679.16 PIK41095.1 - 9.8e-30 102.5 0.4 5.1e-13 48.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Pkinase PF00069.25 PIK41095.1 - 2.9e-28 99.0 0.0 1.1e-27 97.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK41095.1 - 3.7e-26 91.5 0.0 4.1e-09 36.9 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK41095.1 - 3.6e-20 71.9 0.7 3.2e-05 24.0 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK41095.1 - 4.1e-18 65.5 0.1 9.5e-07 29.1 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK41095.1 - 2.3e-10 40.6 3.7 0.014 15.5 0.0 5.0 3 2 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK41095.1 - 8.5e-08 31.6 0.0 0.07 12.7 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 PIK41095.1 - 2.8e-06 27.6 1.9 1.2 9.6 0.3 4.2 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK41095.1 - 1.3e-05 25.2 0.0 0.092 12.8 0.0 3.6 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 PIK41095.1 - 0.0093 16.1 0.0 19 5.5 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin C2-set domain fn3 PF00041.21 PIK41095.1 - 0.015 15.6 1.4 0.035 14.4 0.5 2.1 2 0 0 2 2 2 0 Fibronectin type III domain Herpes_gE PF02480.16 PIK41095.1 - 0.021 13.6 0.6 0.075 11.8 0.0 2.1 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E DUF4279 PF14106.6 PIK41096.1 - 0.11 12.7 0.4 1.8 8.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4279) DUF1230 PF06799.11 PIK41097.1 - 0.16 12.1 0.7 1.7 8.8 0.2 2.2 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 p450 PF00067.22 PIK41098.1 - 7.3e-36 123.9 0.0 1.3e-35 123.1 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.21 PIK41099.1 - 1.4e-19 70.4 0.1 2.1e-19 69.9 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK41099.1 - 0.0017 17.8 0.2 0.0023 17.3 0.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.25 PIK41100.1 - 2.4e-50 171.3 0.0 3.8e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41100.1 - 1.5e-22 80.1 0.0 3.4e-22 79.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK41100.1 - 0.022 14.1 0.1 0.045 13.1 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2847 PF11009.8 PIK41100.1 - 0.027 14.4 0.5 0.059 13.3 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2847) SHIPPO-rpt PF07004.12 PIK41101.1 - 1e-18 67.3 34.2 4.3e-06 27.4 4.9 5.9 5 1 0 5 5 5 5 Sperm-tail PG-rich repeat EGF_CA PF07645.15 PIK41102.1 - 4e-26 90.9 61.0 3.7e-10 39.8 7.0 8.6 9 0 0 9 9 7 4 Calcium-binding EGF domain cEGF PF12662.7 PIK41102.1 - 2.7e-11 43.2 77.1 1.2e-05 25.1 1.8 8.6 9 0 0 9 9 7 5 Complement Clr-like EGF-like VWC PF00093.18 PIK41102.1 - 1.2e-09 38.4 16.9 1.2e-09 38.4 16.9 7.6 3 1 2 5 5 3 2 von Willebrand factor type C domain Laminin_G_3 PF13385.6 PIK41102.1 - 8.7e-09 35.7 0.0 1.4e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_3 PF12947.7 PIK41102.1 - 7.2e-07 29.3 104.2 8.3e-06 25.9 12.1 9.1 7 2 0 7 7 7 4 EGF domain EGF PF00008.27 PIK41102.1 - 1e-06 28.9 35.7 0.00027 21.2 6.5 9.0 10 0 0 10 10 10 5 EGF-like domain Laminin_G_2 PF02210.24 PIK41102.1 - 2.7e-05 24.7 0.0 5.5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 PIK41102.1 - 4.2e-05 24.0 105.6 0.00076 20.0 4.6 11.2 11 0 0 11 11 9 5 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK41102.1 - 6.4e-05 22.9 67.8 0.0072 16.3 1.1 7.9 8 0 0 8 8 7 5 MSP1 EGF domain 1 Laminin_G_1 PF00054.23 PIK41102.1 - 0.0015 18.8 0.0 0.0028 17.9 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain EGF_2 PF07974.13 PIK41102.1 - 0.0072 16.7 14.5 0.0072 16.7 14.5 9.0 7 2 1 8 8 5 2 EGF-like domain EGF PF00008.27 PIK41103.1 - 0.0025 18.1 110.4 0.4 11.0 7.7 7.0 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK41103.1 - 0.03 15.0 72.4 1.4 9.7 1.6 8.8 6 4 1 7 7 7 0 Human growth factor-like EGF EGF PF00008.27 PIK41104.1 - 0.013 15.8 30.3 0.036 14.4 9.9 7.1 6 2 2 8 8 8 0 EGF-like domain EGF PF00008.27 PIK41105.1 - 1.1e-07 32.0 73.0 0.0049 17.1 10.8 5.9 4 3 2 6 6 6 4 EGF-like domain hEGF PF12661.7 PIK41105.1 - 0.0088 16.6 7.5 0.0088 16.6 7.5 7.7 7 2 0 7 7 7 4 Human growth factor-like EGF S4 PF01479.25 PIK41106.1 - 6.1e-11 41.9 2.0 1.9e-10 40.3 2.0 1.9 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 PIK41106.1 - 1.1e-05 26.2 0.9 1.1e-05 26.2 0.9 1.9 2 1 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain zf-RING_2 PF13639.6 PIK41107.1 - 1.6e-08 34.8 18.3 1.6e-08 34.8 18.3 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK41107.1 - 5.1e-08 32.6 18.4 8.9e-08 31.9 18.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK41107.1 - 9.5e-07 28.6 15.6 9.5e-07 28.6 15.6 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK41107.1 - 9.7e-07 28.6 19.5 1.9e-06 27.6 19.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK41107.1 - 4.9e-06 26.5 14.2 1.2e-05 25.3 14.0 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK41107.1 - 0.00012 21.9 15.6 0.0002 21.2 15.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK41107.1 - 0.00022 21.4 16.4 0.00022 21.4 16.4 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 PIK41107.1 - 0.0016 18.4 17.5 0.015 15.2 18.2 2.2 1 1 1 2 2 2 1 zinc-RING finger domain U-box PF04564.15 PIK41107.1 - 0.033 14.4 0.2 0.045 13.9 0.2 1.2 1 0 0 1 1 1 0 U-box domain zf-ANAPC11 PF12861.7 PIK41107.1 - 0.039 14.0 8.8 0.16 12.0 8.9 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 PIK41107.1 - 0.2 11.3 10.7 0.42 10.3 10.7 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.5 PIK41107.1 - 0.22 11.7 16.3 0.33 11.1 16.3 1.4 1 1 0 1 1 1 0 zinc RING finger of MSL2 Met_gamma_lyase PF06838.11 PIK41107.1 - 0.24 9.9 0.1 0.28 9.6 0.1 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase zf-C3HC4_4 PF15227.6 PIK41107.1 - 0.36 11.0 20.6 0.081 13.1 16.9 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 PIK41107.1 - 1.2 9.1 11.9 2.2 8.2 11.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Succ_CoA_lig PF13607.6 PIK41108.1 - 0.027 14.3 0.1 0.032 14.0 0.1 1.0 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain Sulfatase PF00884.23 PIK41109.1 - 1.4e-63 215.2 0.0 1.7e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK41109.1 - 1.6e-21 77.3 0.0 3.3e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK41109.1 - 0.011 15.4 0.1 0.079 12.5 0.1 2.2 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK41109.1 - 0.16 10.5 0.0 0.52 8.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF229) VWC PF00093.18 PIK41110.1 - 2.3e-08 34.2 33.2 8.8e-05 22.8 10.8 2.9 3 0 0 3 3 3 2 von Willebrand factor type C domain TILa PF12714.7 PIK41110.1 - 0.0013 18.7 24.3 0.018 15.0 7.4 2.6 2 0 0 2 2 2 2 TILa domain CFC PF09443.10 PIK41110.1 - 0.0032 17.3 12.5 0.3 10.9 3.7 2.8 2 0 0 2 2 2 2 Cripto_Frl-1_Cryptic (CFC) DUF4692 PF15763.5 PIK41110.1 - 0.099 13.1 3.0 6 7.3 0.0 2.3 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) FAM195 PF14799.6 PIK41111.1 - 1.8e-08 34.7 1.0 2.8e-08 34.0 0.7 1.4 1 1 0 1 1 1 1 FAM195 family RRM_1 PF00076.22 PIK41112.1 - 5.4e-21 74.2 0.0 7.3e-21 73.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 PIK41112.1 - 0.00062 20.4 14.1 0.00098 19.8 14.1 1.3 1 0 0 1 1 1 1 Glycine rich protein family Nup35_RRM_2 PF14605.6 PIK41112.1 - 0.033 14.2 0.1 0.049 13.6 0.1 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 PIK41112.1 - 0.055 13.1 0.0 0.069 12.7 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hyd_WA PF06462.12 PIK41113.1 - 1.2e-49 166.0 61.7 2.8e-09 36.8 0.3 10.6 11 0 0 11 11 11 8 Propeller Pex24p PF06398.11 PIK41113.1 - 2.5e-09 36.6 19.8 5.5e-07 28.9 11.1 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin PH PF00169.29 PIK41113.1 - 0.005 17.3 0.1 0.019 15.5 0.1 2.1 1 0 0 1 1 1 1 PH domain MSP1_C PF07462.11 PIK41113.1 - 0.15 10.7 0.8 0.25 10.0 0.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF4371 PF14291.6 PIK41114.1 - 4.2e-17 62.6 2.0 5.6e-17 62.2 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Peptidase_C65 PF10275.9 PIK41114.1 - 0.022 14.2 0.9 0.029 13.8 0.9 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain DUF3774 PF12609.8 PIK41114.1 - 1.3 10.1 3.3 1.2 10.3 1.2 2.1 2 1 0 2 2 2 0 Wound-induced protein Dimer_Tnp_hAT PF05699.14 PIK41115.1 - 6.8e-08 32.2 0.5 1.8e-07 30.9 0.5 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK41115.1 - 5.2e-06 26.3 0.0 1.1e-05 25.3 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) KR PF08659.10 PIK41115.1 - 0.035 14.0 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 KR domain DUF3164 PF11363.8 PIK41115.1 - 0.04 13.5 0.3 0.29 10.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3164) Snf7 PF03357.21 PIK41115.1 - 0.27 10.8 1.6 13 5.3 0.1 2.5 2 0 0 2 2 2 0 Snf7 SPOUT_MTase PF02590.17 PIK41116.1 - 0.4 10.6 5.0 0.2 11.6 0.3 2.4 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase Siah-Interact_N PF09032.11 PIK41116.1 - 9.6 6.6 10.3 0.37 11.1 3.3 2.4 3 0 0 3 3 3 0 Siah interacting protein, N terminal RVT_1 PF00078.27 PIK41117.1 - 5.8e-09 35.8 0.1 9.9e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) fn3 PF00041.21 PIK41118.1 - 3.1e-06 27.5 0.5 7.4e-06 26.2 0.5 1.6 1 0 0 1 1 1 1 Fibronectin type III domain PBD PF00786.28 PIK41119.1 - 0.00068 19.9 0.1 0.0016 18.8 0.1 1.7 2 0 0 2 2 2 1 P21-Rho-binding domain Phage_int_SAM_4 PF13495.6 PIK41120.1 - 0.016 15.7 0.0 0.036 14.5 0.0 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK41120.1 - 0.027 14.2 0.0 0.062 13.1 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family Phage_int_SAM_1 PF02899.17 PIK41120.1 - 0.09 13.1 0.1 0.09 13.1 0.1 2.0 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 PIK41121.1 - 9e-08 31.9 0.0 2.2e-07 30.6 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK41121.1 - 4.9e-05 23.6 0.1 0.00028 21.1 0.1 2.2 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41121.1 - 0.032 14.3 0.1 0.18 11.9 0.1 2.2 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Phage_integrase PF00589.22 PIK41124.1 - 0.00059 19.7 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family NACHT PF05729.12 PIK41125.1 - 1.2e-05 25.3 0.0 2.9e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Mrr_N PF14338.6 PIK41125.1 - 0.2 11.8 0.4 38 4.5 0.0 3.2 4 0 0 4 4 4 0 Mrr N-terminal domain CCDC-167 PF15188.6 PIK41126.1 - 0.98 9.8 4.2 2.3 8.6 4.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 zf-RVT PF13966.6 PIK41127.1 - 0.00041 21.0 2.8 0.00073 20.2 2.8 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase PDDEXK_10 PF07788.11 PIK41127.1 - 0.19 11.7 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily NACHT PF05729.12 PIK41129.1 - 4.5e-18 65.7 0.0 1.3e-17 64.2 0.0 1.8 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK41129.1 - 5.4e-06 26.4 3.7 0.017 15.2 0.1 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK41129.1 - 1.6e-05 25.0 1.3 0.27 11.4 0.0 3.7 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41129.1 - 3.5e-05 24.3 6.0 0.55 10.9 0.0 5.4 4 1 0 4 4 4 1 Immunoglobulin domain Marek_A PF02124.15 PIK41129.1 - 0.014 15.3 2.1 0.035 13.9 2.1 1.6 1 0 0 1 1 1 0 Marek's disease glycoprotein A AAA_25 PF13481.6 PIK41129.1 - 0.02 14.5 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 PIK41129.1 - 0.021 14.8 0.4 0.021 14.8 0.4 2.0 2 0 0 2 2 2 0 TMEM154 protein family GPI2 PF06432.11 PIK41129.1 - 0.027 13.9 1.1 0.13 11.7 0.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_22 PF13401.6 PIK41129.1 - 0.068 13.4 0.0 0.22 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain ECSCR PF15820.5 PIK41129.1 - 0.07 13.0 0.5 0.22 11.3 0.5 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DAP3 PF10236.9 PIK41129.1 - 0.086 12.0 0.0 0.27 10.4 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 FGFR3_TM PF18123.1 PIK41129.1 - 3.7 7.1 9.2 12 5.5 9.2 1.9 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain ABC_tran PF00005.27 PIK41130.1 - 7.7e-07 29.7 0.1 2.3e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 PIK41130.1 - 0.071 12.5 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 PIK41130.1 - 0.11 11.3 0.4 0.14 11.0 0.4 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RecO_N PF11967.8 PIK41130.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Recombination protein O N terminal UL45 PF05473.12 PIK41131.1 - 0.00058 19.5 0.1 0.00058 19.5 0.1 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK41131.1 - 0.11 13.3 0.0 0.17 12.6 0.0 1.3 1 0 0 1 1 1 0 Lectin C-type domain SRCR PF00530.18 PIK41132.1 - 0.00018 21.9 0.0 0.00035 21.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain PepSY_TM PF03929.16 PIK41132.1 - 0.2 11.3 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region RVT_1 PF00078.27 PIK41134.1 - 3.8e-23 82.2 0.0 5.3e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_8 PF13855.6 PIK41135.1 - 6.5e-28 96.3 20.4 5.2e-16 58.2 6.0 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK41135.1 - 3.4e-10 40.0 13.6 2e-06 28.1 2.9 2.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK41135.1 - 8.1e-07 28.7 10.0 0.0053 17.1 0.1 4.8 3 1 1 4 4 4 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK41135.1 - 4.8e-06 26.2 8.0 1 9.6 0.0 4.7 4 1 1 5 5 5 3 Leucine Rich repeat LRR_5 PF13306.6 PIK41135.1 - 2.3e-05 24.4 0.1 3.3e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK41135.1 - 0.0002 20.9 0.7 0.00026 20.6 0.7 1.1 1 0 0 1 1 1 1 Leucine-rich repeat CDC24_OB3 PF17244.2 PIK41135.1 - 0.0013 18.5 4.3 0.0017 18.1 4.3 1.3 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 Herpes_BTRF1 PF04682.12 PIK41135.1 - 0.032 13.6 0.3 0.052 12.9 0.3 1.5 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region LRR_8 PF13855.6 PIK41136.1 - 2.7e-24 84.7 16.5 4.3e-15 55.2 3.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK41136.1 - 7e-09 35.8 12.6 1.1e-05 25.7 0.8 2.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK41136.1 - 2.4e-05 24.0 4.5 2.4 8.4 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 PIK41136.1 - 0.00031 20.9 11.9 0.11 13.1 0.2 4.9 3 1 1 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK41136.1 - 0.0066 16.0 1.3 0.01 15.4 1.3 1.2 1 0 0 1 1 1 1 Leucine-rich repeat Herpes_BTRF1 PF04682.12 PIK41136.1 - 0.21 10.9 0.1 0.36 10.1 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region DUF2087 PF09860.9 PIK41137.1 - 0.11 12.6 0.4 14 5.9 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) FAST_1 PF06743.15 PIK41138.1 - 5e-11 42.4 0.6 1.3e-10 41.0 0.3 1.8 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 PIK41138.1 - 3.7e-06 27.6 0.0 7.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 DNA_pol_A PF00476.20 PIK41139.1 - 1.2e-51 175.9 0.0 2.4e-51 175.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A DNApol_Exo PF18136.1 PIK41139.1 - 0.00021 20.5 0.0 0.00021 20.5 0.0 1.8 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain rRNA_processing PF08524.11 PIK41139.1 - 5.7 7.0 14.6 5.9 6.9 3.8 2.3 2 0 0 2 2 2 0 rRNA processing SUIM_assoc PF16619.5 PIK41140.1 - 7.1 6.8 12.6 62 3.8 0.0 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 KH_1 PF00013.29 PIK41141.1 - 0.12 12.3 0.0 0.7 9.8 0.0 2.2 2 0 0 2 2 2 0 KH domain 7tm_1 PF00001.21 PIK41142.1 - 7e-35 120.6 9.0 8.9e-35 120.3 9.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK41142.1 - 2.5e-08 33.6 14.1 9.5e-07 28.4 14.1 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK41142.1 - 3.8e-07 29.7 13.1 1.1e-06 28.2 4.3 2.7 3 0 0 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK41142.1 - 3.5e-05 23.6 13.8 3.5e-05 23.6 13.8 2.6 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx GalP_UDP_transf PF01087.22 PIK41143.1 - 8.3e-60 202.4 0.5 1.3e-59 201.7 0.2 1.4 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 PIK41143.1 - 1.2e-50 171.5 0.1 2.2e-50 170.6 0.1 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 PIK41143.1 - 0.00028 21.5 0.0 0.0055 17.4 0.0 2.2 1 1 1 2 2 2 1 HIT domain DUF4186 PF13811.6 PIK41143.1 - 0.099 12.7 0.1 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) zf-CCHC_4 PF14392.6 PIK41143.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle DcpS_C PF11969.8 PIK41143.1 - 0.12 12.9 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding UQ_con PF00179.26 PIK41144.1 - 1.4e-18 66.9 0.2 1.7e-18 66.6 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK41144.1 - 0.14 12.4 0.1 0.19 12.0 0.1 1.2 1 0 0 1 1 1 0 RWD domain Gal-3-0_sulfotr PF06990.11 PIK41146.1 - 1e-20 74.0 1.2 1.2e-20 73.8 1.2 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK41146.1 - 0.0031 17.0 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 PIK41146.1 - 0.025 14.5 0.0 0.047 13.6 0.0 1.5 1 1 0 1 1 1 0 Sulfotransferase family Acetyltransf_1 PF00583.25 PIK41147.1 - 3.8e-05 23.9 0.0 6.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK41147.1 - 5.8e-05 23.4 0.0 0.0001 22.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK41147.1 - 0.0038 17.2 0.0 0.019 14.9 0.0 2.0 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 PIK41147.1 - 0.07 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 PIK41147.1 - 0.15 12.1 0.1 22 5.1 0.2 2.9 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Nucleoplasmin PF03066.15 PIK41148.1 - 1.2e-27 96.4 0.0 1.9e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain Fes1 PF08609.10 PIK41149.1 - 2.3e-05 25.2 14.3 9.4e-05 23.2 9.8 3.5 3 1 0 3 3 3 1 Nucleotide exchange factor Fes1 Arm PF00514.23 PIK41149.1 - 0.0074 16.3 0.2 6.9 6.9 0.0 3.1 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 PIK41149.1 - 0.018 15.1 3.5 0.093 12.8 0.3 3.2 2 1 2 4 4 4 0 V-ATPase subunit H HEAT_2 PF13646.6 PIK41149.1 - 0.028 14.8 0.3 0.13 12.7 0.1 2.2 2 0 0 2 2 2 0 HEAT repeats RICTOR_N PF14664.6 PIK41149.1 - 0.036 13.0 2.3 5.4 5.9 0.0 2.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term CorA PF01544.18 PIK41149.1 - 1.1 8.6 6.1 2.1 7.6 6.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein BOFC_N PF08977.10 PIK41149.1 - 2.4 8.2 7.7 7 6.7 0.7 3.3 4 0 0 4 4 4 0 Bypass of Forespore C, N terminal Hydrolase_6 PF13344.6 PIK41150.1 - 1.3e-15 57.3 0.0 2.1e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase 7tm_1 PF00001.21 PIK41151.1 - 4.8e-63 212.9 17.4 5.9e-63 212.7 17.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41151.1 - 7.2e-11 42.2 10.0 7.2e-11 42.2 10.0 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx zf-LITAF-like PF10601.9 PIK41151.1 - 0.84 9.9 6.5 0.098 12.9 0.8 2.4 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain LapA_dom PF06305.11 PIK41151.1 - 1.2 9.0 0.0 1.2 9.0 0.0 4.0 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Pkinase_Tyr PF07714.17 PIK41152.1 - 1.1e-27 96.9 0.0 1.3e-27 96.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41152.1 - 5.4e-17 62.0 0.0 6.7e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK41152.1 - 0.18 11.1 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ig_3 PF13927.6 PIK41153.1 - 7.9e-11 42.4 2.2 0.00044 20.8 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41153.1 - 4.6e-08 33.3 1.4 0.0011 19.2 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41153.1 - 1.8e-07 31.1 0.6 0.0056 16.7 0.0 2.6 1 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK41153.1 - 8.3e-07 29.2 0.1 0.00011 22.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK41153.1 - 9.8e-06 25.7 2.2 0.22 11.7 0.0 3.1 2 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK41153.1 - 0.0015 18.5 1.9 0.0028 17.7 1.9 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK41153.1 - 0.087 13.2 0.2 0.31 11.4 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK41153.1 - 0.089 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Sipho_Gp157 PF05565.11 PIK41154.1 - 0.00069 19.7 5.0 0.001 19.1 5.0 1.3 1 0 0 1 1 1 1 Siphovirus Gp157 YabA PF06156.13 PIK41154.1 - 0.0035 18.0 2.4 0.0078 16.8 2.4 1.6 1 0 0 1 1 1 1 Initiation control protein YabA HD_2 PF12917.7 PIK41154.1 - 0.011 15.5 0.9 0.02 14.6 0.9 1.4 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Seryl_tRNA_N PF02403.22 PIK41154.1 - 0.015 15.6 5.5 0.04 14.1 5.5 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 PIK41154.1 - 0.063 13.3 3.8 0.12 12.5 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TSNAXIP1_N PF15739.5 PIK41154.1 - 0.094 13.1 3.7 9.3 6.7 3.5 2.5 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus Med9 PF07544.13 PIK41154.1 - 0.11 12.5 5.6 0.4 10.8 5.1 2.1 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Wtap PF17098.5 PIK41154.1 - 0.17 11.8 5.0 0.28 11.1 5.0 1.4 1 0 0 1 1 1 0 WTAP/Mum2p family Swi5 PF07061.11 PIK41154.1 - 0.2 11.8 3.0 0.42 10.7 3.0 1.6 1 0 0 1 1 1 0 Swi5 DivIC PF04977.15 PIK41154.1 - 0.31 10.8 3.0 0.97 9.2 2.0 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF743 PF05332.11 PIK41154.1 - 0.36 10.9 2.5 0.65 10.1 1.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF743) DUF724 PF05266.14 PIK41154.1 - 0.41 10.4 4.8 0.53 10.1 3.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 PIK41154.1 - 1.6 8.8 7.1 2.2 8.3 7.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ig_3 PF13927.6 PIK41155.1 - 3.4e-11 43.6 1.8 5.5e-05 23.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK41155.1 - 2.8e-09 37.1 0.6 1.2e-07 31.9 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK41155.1 - 1.1e-08 35.1 2.4 0.002 18.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41155.1 - 3.8e-08 33.6 2.0 0.0014 19.0 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41155.1 - 2.6e-07 30.6 1.2 0.00071 19.6 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK41155.1 - 6e-05 23.0 0.6 0.00011 22.2 0.6 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Plasmod_Pvs28 PF06247.11 PIK41155.1 - 0.031 14.6 0.1 0.093 13.1 0.1 1.9 1 0 0 1 1 1 0 Pvs28 EGF domain Izumo-Ig PF16706.5 PIK41155.1 - 0.062 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain HC2 PF07382.11 PIK41156.1 - 0.0011 19.1 4.6 0.0016 18.5 4.6 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Fibrinogen_BP PF08017.11 PIK41156.1 - 0.046 12.2 23.8 0.047 12.1 23.8 1.0 1 0 0 1 1 1 0 Fibrinogen binding protein DEADboxA PF12343.8 PIK41156.1 - 0.28 11.7 8.8 37 4.9 0.3 3.3 1 1 1 2 2 2 0 Cold shock protein DEAD box A NICE-1 PF15845.5 PIK41156.1 - 3.1 8.6 18.2 16 6.3 1.8 4.2 1 1 5 6 6 6 0 Cysteine-rich C-terminal 1 family PAX PF00292.18 PIK41158.1 - 5.2e-32 110.4 0.1 8.5e-32 109.7 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 PIK41158.1 - 7.8e-24 83.3 4.5 1.5e-23 82.4 4.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK41158.1 - 0.00027 20.8 0.0 0.00078 19.3 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Vps62 PF06101.11 PIK41159.1 - 1.1e-15 57.0 0.0 6.2e-09 34.7 0.0 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 62 DUF4407 PF14362.6 PIK41160.1 - 0.01 15.2 2.4 0.015 14.6 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HTH_12 PF08461.10 PIK41160.1 - 0.052 13.5 2.2 0.067 13.2 0.6 2.0 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain DUF3103 PF11301.8 PIK41160.1 - 0.079 11.7 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) Ephrin_rec_like PF07699.13 PIK41162.1 - 0.0003 20.5 21.4 0.00071 19.3 8.0 82.5 59 26 28 87 87 87 43 Putative ephrin-receptor like THOC2_N PF16134.5 PIK41163.1 - 0.0011 17.7 0.2 0.0015 17.2 0.2 1.1 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Npun_R1517 PF18068.1 PIK41163.1 - 0.013 15.9 1.0 0.73 10.2 0.1 2.6 2 1 0 2 2 2 0 Npun R1517 RVT_1 PF00078.27 PIK41164.1 - 8.1e-08 32.0 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Plexin_cytopl PF08337.12 PIK41165.1 - 2.8e-38 131.9 0.8 3.4e-38 131.7 0.8 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 PIK41166.1 - 1.9e-32 112.6 5.6 3.6e-31 108.4 5.6 2.4 1 1 0 1 1 1 1 Sema domain TIG PF01833.24 PIK41166.1 - 1.6e-28 98.6 22.5 3.2e-10 39.9 2.5 7.0 7 0 0 7 7 7 4 IPT/TIG domain TIG_plexin PF17960.1 PIK41166.1 - 1.3e-15 57.1 4.8 1.1e-14 54.2 0.2 3.4 3 0 0 3 3 3 1 TIG domain TIG_2 PF18020.1 PIK41166.1 - 3.2e-11 43.7 2.7 5.7e-11 42.9 0.6 2.7 2 0 0 2 2 2 1 TIG domain found in plexin PSI PF01437.25 PIK41166.1 - 6.1e-10 39.5 47.5 3.5e-07 30.7 10.8 3.8 3 0 0 3 3 3 3 Plexin repeat Runt PF00853.19 PIK41166.1 - 0.098 12.2 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 Runt domain Plexin_cytopl PF08337.12 PIK41167.1 - 4e-88 296.5 14.3 6.8e-56 190.1 0.9 2.6 3 0 0 3 3 3 2 Plexin cytoplasmic RasGAP domain TIG PF01833.24 PIK41167.1 - 7.7e-23 80.4 16.6 1.5e-09 37.8 0.5 5.9 6 0 0 6 6 6 4 IPT/TIG domain TMEM154 PF15102.6 PIK41167.1 - 0.071 13.0 0.0 0.24 11.3 0.0 1.9 1 0 0 1 1 1 0 TMEM154 protein family DUF3452 PF11934.8 PIK41167.1 - 0.1 12.2 1.2 0.26 10.8 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) TFIIS_M PF07500.14 PIK41167.1 - 0.11 13.0 0.3 3.5 8.1 0.0 2.8 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS), central domain FixS PF03597.15 PIK41167.1 - 0.23 11.2 2.7 0.23 11.2 0.9 1.9 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type DUF1512 PF07431.12 PIK41167.1 - 0.27 10.2 0.7 0.53 9.2 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) NACHT PF05729.12 PIK41168.1 - 3e-12 46.8 0.0 6e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK41168.1 - 7.7e-06 25.6 0.0 0.0069 16.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 PIK41168.1 - 0.0095 16.3 0.2 0.18 12.2 0.0 2.7 2 2 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 PIK41168.1 - 0.064 13.5 0.0 0.19 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain ER PF01133.17 PIK41168.1 - 0.081 13.0 0.5 0.24 11.4 0.1 2.0 2 0 0 2 2 2 0 Enhancer of rudimentary DAP3 PF10236.9 PIK41168.1 - 0.081 12.1 0.0 0.19 10.8 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 C2-set_2 PF08205.12 PIK41169.1 - 4.7e-05 23.4 0.2 8.6e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK41169.1 - 0.00024 21.4 0.5 0.00049 20.4 0.5 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Syndecan PF01034.20 PIK41169.1 - 0.57 10.1 2.9 0.98 9.4 2.9 1.3 1 0 0 1 1 1 0 Syndecan domain Sigma_reg_N PF13800.6 PIK41169.1 - 0.8 10.0 6.2 28 5.1 0.1 3.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal NdhM PF10664.9 PIK41170.1 - 0.0021 18.3 0.3 0.075 13.3 0.2 2.4 2 0 0 2 2 2 1 Cyanobacterial and plastid NDH-1 subunit M DUF4768 PF15989.5 PIK41170.1 - 0.042 13.8 1.5 2.8 8.0 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4768) BEN PF10523.9 PIK41171.1 - 1e-06 28.8 0.1 2.7e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 BEN domain DUF4763 PF15960.5 PIK41171.1 - 0.011 15.0 0.7 0.018 14.3 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) RHD3 PF05879.12 PIK41173.1 - 6.2e-14 51.1 3.9 6e-13 47.9 0.1 2.9 2 1 1 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK41173.1 - 5.2e-07 29.9 0.8 4.3e-06 26.9 0.1 2.6 2 1 1 3 3 3 1 Dynamin family GBP PF02263.19 PIK41173.1 - 2.6e-06 26.9 0.1 5.3e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 PIK41173.1 - 3.7e-06 27.0 0.0 1.1e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase OmpH PF03938.14 PIK41173.1 - 0.038 14.3 6.1 1.2 9.4 0.1 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) AAA_16 PF13191.6 PIK41173.1 - 0.084 13.2 0.3 0.35 11.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 PIK41173.1 - 0.087 12.0 6.1 0.84 8.7 0.0 2.8 3 0 0 3 3 3 0 G-protein alpha subunit APG6_N PF17675.1 PIK41173.1 - 0.77 10.3 13.2 36 4.9 0.0 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region Laminin_II PF06009.12 PIK41173.1 - 1.9 8.5 7.2 0.5 10.4 1.8 2.6 3 0 0 3 3 3 0 Laminin Domain II zf-Nse PF11789.8 PIK41177.1 - 1.2e-16 60.3 2.1 2.2e-16 59.4 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 PIK41177.1 - 9.3e-06 25.6 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.15 PIK41177.1 - 5.7e-05 23.2 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-MIZ PF02891.20 PIK41177.1 - 0.0013 18.4 1.0 0.0013 18.4 1.0 1.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 PIK41177.1 - 0.0037 17.1 0.1 0.0084 15.9 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK41177.1 - 0.19 12.1 1.3 0.36 11.2 1.3 1.5 1 0 0 1 1 1 0 Ring finger domain Ras PF00071.22 PIK41178.1 - 1.8e-26 92.7 0.1 2.8e-12 46.5 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK41178.1 - 4.6e-13 49.4 0.1 1.3e-11 44.8 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DnaJ PF00226.31 PIK41178.1 - 1.7e-10 40.9 0.0 3.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Arf PF00025.21 PIK41178.1 - 2e-07 30.7 0.0 0.014 14.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK41178.1 - 0.015 15.4 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Plant_zn_clust PF10533.9 PIK41178.1 - 0.051 13.6 0.2 0.11 12.5 0.2 1.6 1 0 0 1 1 1 0 Plant zinc cluster domain GTP_EFTU PF00009.27 PIK41178.1 - 0.073 12.6 0.0 3.8 7.0 0.0 2.7 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 PIK41178.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain CUB PF00431.20 PIK41179.1 - 0.025 14.9 0.0 0.13 12.6 0.0 2.1 1 1 0 1 1 1 0 CUB domain SSF PF00474.17 PIK41181.1 - 9.6e-24 84.0 14.5 1.2e-23 83.7 14.5 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family PHO4 PF01384.20 PIK41181.1 - 6.2 5.8 12.5 2.4 7.1 9.8 1.5 1 1 1 2 2 2 0 Phosphate transporter family SSF PF00474.17 PIK41182.1 - 3.6e-07 29.4 0.5 4.6e-07 29.0 0.5 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family HYR PF02494.16 PIK41183.1 - 1.3e-24 86.3 13.9 1.6e-14 54.0 2.2 3.1 3 0 0 3 3 3 3 HYR domain MBF2 PF15868.5 PIK41184.1 - 6.4e-15 55.5 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Transcription activator MBF2 Death PF00531.22 PIK41184.1 - 6.1e-10 39.1 0.1 9.2e-10 38.6 0.1 1.3 1 0 0 1 1 1 1 Death domain COesterase PF00135.28 PIK41185.1 - 7.8e-40 137.2 0.0 9e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Syndecan PF01034.20 PIK41186.1 - 0.0092 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain Rax2 PF12768.7 PIK41186.1 - 0.035 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Shisa PF13908.6 PIK41186.1 - 0.073 13.3 0.2 0.095 12.9 0.2 1.2 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK41186.1 - 0.12 13.2 0.0 0.18 12.7 0.0 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4690 PF15756.5 PIK41186.1 - 0.13 12.9 0.6 0.13 12.9 0.6 2.0 2 0 0 2 2 2 0 Small Novel Rich in Cartilage ODV-E18 PF10717.9 PIK41186.1 - 0.15 12.0 1.0 0.18 11.7 0.1 1.7 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 RVT_1 PF00078.27 PIK41187.1 - 2.8e-15 56.4 0.0 4.2e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Casc1 PF12366.8 PIK41187.1 - 0.089 12.3 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 rve PF00665.26 PIK41188.1 - 3.2e-17 62.8 0.0 6.3e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41188.1 - 0.0014 18.7 1.7 0.0032 17.6 1.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK41188.1 - 0.0018 18.0 0.1 0.016 14.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK41188.1 - 0.054 13.5 0.2 0.094 12.8 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 zf-CCHC PF00098.23 PIK41190.1 - 0.22 11.7 0.4 0.22 11.7 0.4 1.9 2 0 0 2 2 2 0 Zinc knuckle Pkinase_Tyr PF07714.17 PIK41191.1 - 7.7e-42 143.4 0.0 9.4e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41191.1 - 5.9e-18 65.2 0.0 9.9e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41192.1 - 7.5e-45 153.2 0.0 9.1e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41192.1 - 1.1e-17 64.3 0.0 1.7e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sod_Cu PF00080.20 PIK41193.1 - 4e-43 147.0 0.5 3.9e-12 46.6 0.0 6.3 7 0 0 7 7 7 4 Copper/zinc superoxide dismutase (SODC) DUF1622 PF07784.11 PIK41193.1 - 0.22 11.5 0.1 29 4.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1622) GTF2I PF02946.14 PIK41194.1 - 4.7e-10 39.4 0.0 1.2e-09 38.1 0.0 1.7 2 0 0 2 2 2 1 GTF2I-like repeat HMG_box_2 PF09011.10 PIK41194.1 - 0.0082 16.7 2.9 0.011 16.3 2.0 1.7 1 1 0 1 1 1 1 HMG-box domain Acyl-CoA_dh_1 PF00441.24 PIK41195.1 - 7.9e-33 113.8 0.0 8.7e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK41195.1 - 7.9e-09 35.9 0.0 9.9e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain IgGFc_binding PF17517.2 PIK41196.1 - 1.6e-26 93.3 2.5 2.9e-26 92.4 2.5 1.4 1 0 0 1 1 1 1 IgGFc binding protein 7tm_2 PF00002.24 PIK41196.1 - 1.8e-19 70.0 11.1 2.8e-19 69.4 11.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK41196.1 - 6.9e-14 52.1 4.6 3.9e-13 49.7 4.6 2.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Ig_2 PF13895.6 PIK41196.1 - 0.00039 20.7 0.0 0.15 12.4 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK41196.1 - 0.11 12.5 0.1 1.3 9.1 0.0 2.8 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain CUB PF00431.20 PIK41197.1 - 1.8e-30 105.5 0.9 0.0003 21.1 0.0 6.4 6 0 0 6 6 6 6 CUB domain Ldl_recept_a PF00057.18 PIK41197.1 - 2.1e-22 79.0 66.6 2.5e-05 24.4 6.2 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A CheB_methylest PF01339.17 PIK41197.1 - 0.023 14.4 0.0 52 3.5 0.0 3.5 3 0 0 3 3 3 0 CheB methylesterase V-set PF07686.17 PIK41197.1 - 0.11 12.7 0.9 13 6.1 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin V-set domain ADAM_CR_2 PF17771.1 PIK41197.1 - 0.87 10.2 17.8 35 5.0 0.1 5.7 5 0 0 5 5 5 0 ADAM cysteine-rich domain DASH_Dad1 PF08649.10 PIK41198.1 - 0.74 10.0 0.0 0.74 10.0 0.0 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad1 Trimer_CC PF08954.11 PIK41198.1 - 7.5 6.2 18.7 0.23 11.0 1.4 4.6 3 1 0 3 3 3 0 Trimerisation motif Imm42 PF15593.6 PIK41198.1 - 9.3 6.7 7.9 1.8 9.0 1.0 2.5 1 1 1 2 2 2 0 Immunity protein 42 Sulfotransfer_1 PF00685.27 PIK41200.1 - 1.7e-34 119.6 0.0 3.3e-17 62.8 0.0 2.0 1 1 1 2 2 2 2 Sulfotransferase domain SH3BGR PF04908.15 PIK41200.1 - 0.075 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DUF3361 PF11841.8 PIK41202.1 - 1.4e-45 155.0 0.9 3.3e-45 153.8 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 PIK41202.1 - 2.1e-24 86.6 6.5 3e-14 53.5 0.1 2.6 1 1 1 2 2 2 2 ELMO/CED-12 family PH_12 PF16457.5 PIK41202.1 - 2.3e-14 54.1 0.0 5.5e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain CEP209_CC5 PF16574.5 PIK41203.1 - 0.61 10.3 9.4 0.034 14.3 3.4 2.0 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Fibrinogen_C PF00147.18 PIK41204.1 - 5.7e-35 121.1 1.2 6.7e-35 120.9 1.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain YaiA PF16362.5 PIK41204.1 - 0.062 13.4 0.0 0.29 11.3 0.0 1.9 2 0 0 2 2 2 0 YaiA protein Fibrinogen_C PF00147.18 PIK41205.1 - 9e-43 146.6 1.5 1.5e-42 145.9 1.5 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK41205.1 - 2.3e-06 27.7 8.8 2.3e-06 27.7 8.8 3.1 3 1 0 3 3 3 1 EGF domain TIL PF01826.17 PIK41205.1 - 0.00046 20.4 11.8 0.00046 20.4 11.8 2.4 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK41206.1 - 2.9e-77 259.4 9.5 1.8e-42 145.6 1.2 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK41206.1 - 4.4e-14 52.2 49.8 1.3e-06 28.2 4.1 5.3 3 1 2 5 5 5 3 TILa domain EGF_3 PF12947.7 PIK41206.1 - 5.9e-10 39.2 72.8 7e-05 22.9 10.8 7.0 4 3 3 7 7 7 3 EGF domain EGF_MSP1_1 PF12946.7 PIK41206.1 - 1.4e-08 34.7 42.2 0.0021 18.1 4.5 5.4 4 0 0 4 4 4 3 MSP1 EGF domain 1 TIL PF01826.17 PIK41206.1 - 0.0015 18.7 14.0 0.0015 18.7 14.0 5.6 4 3 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Crystall PF00030.19 PIK41206.1 - 0.0056 16.9 4.9 12 6.2 0.1 4.3 4 0 0 4 4 4 2 Beta/Gamma crystallin EGF_2 PF07974.13 PIK41206.1 - 0.012 15.9 59.6 0.098 13.1 9.3 6.2 4 1 0 4 4 4 0 EGF-like domain Fibrinogen_C PF00147.18 PIK41207.1 - 7.7e-16 58.6 16.4 2e-12 47.4 9.0 3.0 1 1 2 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain Chalcone_N PF18232.1 PIK41207.1 - 0.66 10.4 5.2 0.98 9.9 1.1 2.3 2 0 0 2 2 2 0 Chalcone isomerase N-terminal domain Pox_C7_F8A PF03287.14 PIK41207.1 - 0.76 9.8 3.7 0.58 10.1 1.7 1.7 2 0 0 2 2 2 0 Poxvirus C7/F8A protein Fibrinogen_C PF00147.18 PIK41208.1 - 6.9e-12 45.6 4.7 6e-10 39.3 0.1 2.5 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK41208.1 - 3.6e-06 27.1 10.0 3.6e-06 27.1 10.0 4.3 3 2 1 4 4 4 1 EGF domain TIL PF01826.17 PIK41208.1 - 0.00019 21.6 11.8 0.00019 21.6 11.8 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK41208.1 - 0.00025 20.9 7.5 0.00025 20.9 7.5 4.2 2 1 2 4 4 4 1 TILa domain Fibrinogen_C PF00147.18 PIK41209.1 - 5.2e-42 144.1 4.8 1.8e-35 122.8 0.8 2.2 1 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK41209.1 - 1.7e-05 24.9 15.0 6.3e-05 23.1 12.5 2.4 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK41209.1 - 0.014 15.4 6.4 0.031 14.2 6.4 1.7 1 0 0 1 1 1 0 TILa domain EGF PF00008.27 PIK41209.1 - 0.096 13.0 3.4 0.28 11.5 3.4 1.8 1 0 0 1 1 1 0 EGF-like domain cEGF PF12662.7 PIK41209.1 - 0.69 9.9 10.0 0.18 11.8 4.1 2.6 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK41209.1 - 1.6 9.2 8.5 4.9 7.6 8.5 2.0 1 1 0 1 1 1 0 EGF-like domain EB PF01683.18 PIK41209.1 - 2.4 8.5 12.2 9.7 6.6 12.2 2.0 1 1 0 1 1 1 0 EB module MFS_1 PF07690.16 PIK41210.1 - 4.9e-23 81.6 29.6 1.8e-15 56.7 8.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily His_binding PF02098.16 PIK41210.1 - 0.2 11.7 2.2 0.5 10.4 2.3 1.6 1 1 0 1 1 1 0 Tick histamine binding protein MFS_1 PF07690.16 PIK41211.1 - 1.5e-05 24.1 0.6 2e-05 23.7 0.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Ion_trans PF00520.31 PIK41212.1 - 3.2e-06 26.5 0.7 4.6e-06 26.0 0.7 1.2 1 0 0 1 1 1 1 Ion transport protein Ig_3 PF13927.6 PIK41214.1 - 2.7e-08 34.3 0.2 0.0016 19.0 0.0 2.9 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41214.1 - 8.7e-06 26.0 0.9 0.13 12.6 0.1 3.5 1 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK41214.1 - 4.5e-05 23.4 0.0 0.00014 21.9 0.0 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK41214.1 - 0.00031 20.9 3.1 4.2 7.6 0.1 3.9 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK41214.1 - 0.00033 20.7 0.1 0.78 9.8 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK41214.1 - 0.0046 17.1 1.4 0.092 12.9 0.2 3.1 2 1 1 4 4 4 1 Immunoglobulin V-set domain DUF2207 PF09972.9 PIK41214.1 - 0.044 12.5 0.0 0.056 12.2 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) BiPBP_C PF06832.12 PIK41214.1 - 0.059 13.4 0.0 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 PIK41214.1 - 0.1 12.9 1.0 1.8 8.9 0.3 2.9 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain NEMO PF11577.8 PIK41215.1 - 0.0018 18.2 0.4 0.0037 17.3 0.4 1.4 1 0 0 1 1 1 1 NF-kappa-B essential modulator NEMO DUF982 PF06169.12 PIK41216.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF982) zf-CCHC PF00098.23 PIK41218.1 - 7.8e-08 32.1 2.1 1.3e-07 31.4 2.1 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK41218.1 - 6.4e-05 22.7 1.6 0.00012 21.8 1.6 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK41218.1 - 0.0016 18.2 2.8 0.0027 17.5 2.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK41218.1 - 0.011 15.7 1.4 0.019 14.9 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK41218.1 - 0.044 13.5 1.9 0.068 12.9 1.9 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK41218.1 - 0.099 12.4 0.8 0.17 11.6 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle HscB_4_cys PF18256.1 PIK41218.1 - 0.75 9.7 3.3 1.5 8.7 3.3 1.5 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif RGM_C PF06534.13 PIK41219.1 - 0.025 14.1 0.9 4.3 6.8 0.1 2.1 2 0 0 2 2 2 0 Repulsive guidance molecule (RGM) C-terminus UCH PF00443.29 PIK41220.1 - 4.9e-05 23.0 1.5 0.066 12.7 0.2 3.2 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase RVT_1 PF00078.27 PIK41221.1 - 1.1e-38 133.0 1.3 1.2e-38 132.9 0.5 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK41222.1 - 1.6e-15 57.2 0.0 2.3e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK41222.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) Zip PF02535.22 PIK41223.1 - 9.4e-54 182.8 8.8 1.9e-44 152.3 0.0 2.8 2 1 1 3 3 3 2 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK41223.1 - 0.00051 20.0 0.2 0.00095 19.1 0.2 1.4 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain CPP1-like PF11833.8 PIK41223.1 - 0.67 9.6 4.3 13 5.4 1.0 2.4 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like ZIP4_domain PF18292.1 PIK41224.1 - 9.4e-14 51.7 1.0 1.9e-13 50.7 0.2 1.7 2 0 0 2 2 2 1 Zinc transporter ZIP4 domain PK PF00224.21 PIK41225.1 - 3.4e-151 503.0 1.6 4.2e-151 502.7 1.6 1.0 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain HpcH_HpaI PF03328.14 PIK41225.1 - 1.9e-05 23.9 0.1 9.9e-05 21.6 0.0 1.9 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family NTP_transf_2 PF01909.23 PIK41225.1 - 0.079 13.3 0.2 0.18 12.1 0.2 1.6 1 1 0 1 1 1 0 Nucleotidyltransferase domain PK_C PF02887.16 PIK41226.1 - 1.6e-30 105.8 0.0 1.9e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Ank_2 PF12796.7 PIK41227.1 - 8.3e-27 93.6 0.0 4.2e-13 49.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK41227.1 - 7.4e-21 73.6 1.1 1.6e-05 25.1 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 PIK41227.1 - 5.9e-19 67.9 1.5 2.7e-09 37.1 0.2 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK41227.1 - 1.1e-18 67.3 0.1 1.1e-06 29.0 0.0 3.6 2 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK41227.1 - 4.5e-18 63.5 0.1 4.1e-05 23.7 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat PEARLI-4 PF05278.12 PIK41227.1 - 0.085 12.4 4.6 0.16 11.6 4.6 1.4 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF563 PF04577.14 PIK41228.1 - 5.6e-15 56.0 0.3 1.2e-14 54.9 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF563) RNA_pol_Rpb1_7 PF04990.12 PIK41228.1 - 0.13 12.3 0.3 0.29 11.1 0.3 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 PUB PF09409.10 PIK41229.1 - 1.7e-23 82.3 0.0 3.9e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 PUB domain UBX PF00789.20 PIK41229.1 - 3e-08 33.7 0.0 7.9e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 UBX domain zf-CpG_bind_C PF12269.8 PIK41229.1 - 0.017 14.9 0.2 0.017 14.9 0.2 2.4 3 0 0 3 3 3 0 CpG binding protein zinc finger C terminal domain zf-C2H2_4 PF13894.6 PIK41229.1 - 0.62 11.0 3.3 0.4 11.6 0.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Ras PF00071.22 PIK41230.1 - 6.4e-45 152.7 1.0 8.8e-45 152.2 1.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41230.1 - 2.6e-30 105.1 0.4 5.6e-30 104.0 0.1 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK41230.1 - 8.4e-11 41.6 0.0 1.2e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK41230.1 - 2.5e-06 27.5 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK41230.1 - 0.00032 20.1 0.1 0.00045 19.6 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK41230.1 - 0.0011 18.5 0.1 0.2 11.2 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain TniB PF05621.11 PIK41230.1 - 0.013 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 PIK41230.1 - 0.027 14.2 0.0 0.1 12.3 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 PIK41230.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 PIK41230.1 - 0.14 11.7 0.3 0.29 10.6 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Ribosomal_L23eN PF03939.13 PIK41231.1 - 8.1e-16 58.0 11.3 1.9e-15 56.8 11.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 PIK41231.1 - 1.5e-15 57.3 3.2 1.5e-15 57.3 3.2 2.1 2 1 0 2 2 2 1 Ribosomal protein L23 Homeodomain PF00046.29 PIK41232.1 - 2e-21 75.6 1.3 3.4e-21 74.9 1.3 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 PIK41232.1 - 0.021 14.3 0.0 0.039 13.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 PIK41232.1 - 0.054 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain YdaS_antitoxin PF15943.5 PIK41232.1 - 0.12 12.3 0.1 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT ParcG PF10274.9 PIK41233.1 - 4.9e-16 59.4 0.0 2.7e-09 37.4 0.0 2.4 1 1 1 2 2 2 2 Parkin co-regulated protein HEAT_EZ PF13513.6 PIK41233.1 - 0.083 13.4 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 HEAT-like repeat PI-PLC-Y PF00387.19 PIK41234.1 - 3.6e-30 104.7 0.7 9.5e-30 103.3 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RA PF00788.23 PIK41234.1 - 2.4e-17 63.3 0.0 5e-12 46.3 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain C2 PF00168.30 PIK41234.1 - 1.5e-12 47.7 0.0 3e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain PI-PLC-X PF00388.19 PIK41235.1 - 7.6e-63 210.4 0.1 1.5e-62 209.5 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.11 PIK41235.1 - 3.9e-07 30.4 0.3 3.9e-07 30.4 0.3 3.9 4 0 0 4 4 4 1 Phosphoinositide-specific phospholipase C, efhand-like PI-PLC-Y PF00387.19 PIK41235.1 - 0.037 14.4 0.3 0.14 12.5 0.3 2.0 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.19 PIK41236.1 - 2.1e-16 60.6 0.0 4.7e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain DUF771 PF05595.11 PIK41236.1 - 0.015 15.2 0.1 0.21 11.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF771) RNA_pol_Rpc82 PF05645.13 PIK41236.1 - 0.043 13.6 0.7 0.11 12.2 0.2 1.9 2 1 0 2 2 2 0 RNA polymerase III subunit RPC82 TPR_7 PF13176.6 PIK41236.1 - 0.11 12.6 0.1 0.52 10.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat FERM_M PF00373.18 PIK41237.1 - 0.0015 18.9 0.1 0.0022 18.4 0.1 1.7 1 1 0 1 1 1 1 FERM central domain 5_nucleotid_C PF02872.18 PIK41239.1 - 2.6e-35 122.0 0.0 3.8e-21 75.9 0.0 2.5 2 0 0 2 2 2 2 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK41239.1 - 7.7e-07 29.8 0.0 2.6e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AftA_C PF12249.8 PIK41239.1 - 0.061 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Arabinofuranosyltransferase A C terminal DUF4431 PF14485.6 PIK41239.1 - 0.27 11.1 2.8 25 4.7 1.4 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4431) DUF913 PF06025.12 PIK41240.1 - 0.0032 16.5 3.7 0.0032 16.5 3.7 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) FGF-BP1 PF06473.12 PIK41240.1 - 0.28 11.0 47.4 0.022 14.6 8.7 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) FAM76 PF16046.5 PIK41240.1 - 0.99 8.7 44.7 0.63 9.3 10.6 2.2 2 0 0 2 2 2 0 FAM76 protein PAX PF00292.18 PIK41241.1 - 9.7e-68 225.8 0.3 1.1e-67 225.7 0.3 1.0 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 PIK41241.1 - 0.00015 22.3 0.1 0.072 13.7 0.0 2.1 2 0 0 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 PIK41241.1 - 0.00039 20.1 0.0 0.00062 19.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 PIK41241.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 InsA C-terminal domain HTH_28 PF13518.6 PIK41241.1 - 0.035 14.2 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Homeodomain PF00046.29 PIK41242.1 - 4.2e-23 81.0 5.8 6.9e-23 80.3 5.8 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK41242.1 - 0.04 13.8 1.9 0.05 13.5 0.2 2.0 2 0 0 2 2 2 0 Homeobox KN domain HD_3 PF13023.6 PIK41242.1 - 0.082 12.8 0.6 0.12 12.3 0.6 1.3 1 0 0 1 1 1 0 HD domain PAXNEB PF05625.11 PIK41243.1 - 1.9e-83 280.7 0.1 2.4e-83 280.3 0.1 1.0 1 0 0 1 1 1 1 PAXNEB protein Hydrolase_6 PF13344.6 PIK41244.1 - 2.2e-23 82.3 0.0 4.9e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK41244.1 - 2e-16 59.8 0.0 3.5e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 PIK41244.1 - 6.4e-07 29.9 0.0 0.00016 22.0 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK41244.1 - 8e-05 22.8 0.0 0.00021 21.5 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Methyltransf_25 PF13649.6 PIK41245.1 - 1.4e-10 41.8 0.0 2.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK41245.1 - 3.7e-10 39.7 0.1 5.1e-10 39.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 PIK41245.1 - 2.7e-07 31.1 0.0 5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41245.1 - 4.8e-07 29.7 0.1 6.3e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK41245.1 - 1.6e-06 28.0 0.0 2.1e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 PIK41245.1 - 1.9e-06 27.1 0.1 2.3e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 PIK41245.1 - 2.7e-06 27.4 0.1 3.9e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK41245.1 - 5.4e-06 25.9 0.0 7.1e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 PIK41245.1 - 2.3e-05 24.0 0.2 3.3e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 PIK41245.1 - 0.0014 18.4 0.2 0.0019 18.0 0.2 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 PIK41245.1 - 0.0017 18.2 0.3 0.0022 17.7 0.3 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PRMT5 PF05185.16 PIK41245.1 - 0.011 15.6 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_15 PF09445.10 PIK41245.1 - 0.023 14.3 0.2 0.031 13.8 0.2 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DOT1 PF08123.13 PIK41245.1 - 0.041 13.4 0.1 0.055 13.0 0.1 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 PIK41245.1 - 0.048 14.4 0.0 0.077 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 PIK41245.1 - 0.088 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 PIK41245.1 - 0.099 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 PIK41245.1 - 0.1 12.0 0.2 0.16 11.5 0.2 1.3 1 0 0 1 1 1 0 Putative methyltransferase RVT_1 PF00078.27 PIK41247.1 - 9.8e-24 84.1 0.1 1.1e-23 83.9 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EphA2_TM PF14575.6 PIK41248.1 - 0.014 16.2 0.8 0.044 14.7 0.0 2.2 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain AJAP1_PANP_C PF15298.6 PIK41248.1 - 0.26 11.5 12.9 0.026 14.8 6.8 2.3 2 1 1 3 3 3 0 AJAP1/PANP C-terminus Stevor PF17410.2 PIK41248.1 - 0.27 10.7 3.5 0.15 11.6 0.2 2.0 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame Lin-8 PF03353.15 PIK41248.1 - 9.7 5.6 12.2 1.8 8.0 8.3 1.6 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist Aldo_ket_red PF00248.21 PIK41249.1 - 1e-44 152.9 0.0 1.3e-44 152.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GpcrRhopsn4 PF10192.9 PIK41250.1 - 5.4e-39 134.1 13.3 1.2e-37 129.7 12.4 2.6 2 1 1 3 3 3 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 PIK41250.1 - 0.0035 16.6 8.4 0.0065 15.7 8.4 1.4 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF2625 PF10946.8 PIK41250.1 - 0.13 11.2 0.1 0.24 10.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 CUB PF00431.20 PIK41251.1 - 3.4e-60 201.2 0.0 1.6e-15 57.4 0.0 5.7 6 0 0 6 6 6 5 CUB domain CUB_2 PF02408.20 PIK41251.1 - 0.17 11.7 0.4 30 4.4 0.0 3.7 4 0 0 4 4 4 0 CUB-like domain Arm PF00514.23 PIK41252.1 - 3.3e-19 68.2 13.8 1.2e-07 31.5 0.1 6.1 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat Ank_5 PF13857.6 PIK41252.1 - 1.6e-05 25.0 0.0 5.3e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT_2 PF13646.6 PIK41252.1 - 1.9e-05 25.0 6.4 0.02 15.3 0.2 3.8 1 1 3 4 4 4 3 HEAT repeats Ank_3 PF13606.6 PIK41252.1 - 0.00032 20.9 0.0 0.0013 19.1 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Atx10homo_assoc PF09759.9 PIK41252.1 - 0.00055 19.9 4.4 0.081 13.0 0.1 3.9 2 2 1 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Ank PF00023.30 PIK41252.1 - 0.00098 19.5 0.0 0.0033 17.8 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 PIK41252.1 - 0.021 15.4 0.0 0.069 13.8 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Adaptin_N PF01602.20 PIK41252.1 - 0.026 13.1 4.8 0.014 14.0 1.3 2.0 1 1 0 1 1 1 0 Adaptin N terminal region Ank_2 PF12796.7 PIK41252.1 - 0.046 14.3 0.2 0.18 12.4 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Arm_2 PF04826.13 PIK41252.1 - 0.088 12.3 3.7 0.063 12.7 0.5 2.2 1 1 1 2 2 2 0 Armadillo-like HEAT PF02985.22 PIK41252.1 - 0.32 11.4 6.7 34 5.1 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat Drf_GBD PF06371.13 PIK41252.1 - 0.38 10.3 4.0 0.73 9.4 0.1 2.7 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain HEAT_EZ PF13513.6 PIK41252.1 - 4.7 7.8 8.6 5.3 7.7 0.7 4.2 3 1 2 5 5 5 0 HEAT-like repeat Arm PF00514.23 PIK41253.1 - 1.2e-07 31.5 4.5 0.5 10.5 0.0 5.8 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK41253.1 - 3.9e-07 30.4 7.9 0.0079 16.6 0.8 3.3 1 1 3 4 4 4 4 HEAT repeats Atx10homo_assoc PF09759.9 PIK41253.1 - 1.9e-05 24.6 1.7 0.12 12.4 0.7 3.6 2 1 1 3 3 3 2 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 PIK41253.1 - 0.014 15.6 2.2 14 6.3 0.1 4.3 4 0 0 4 4 4 0 HEAT repeat IFRD PF05004.13 PIK41253.1 - 0.21 10.7 3.7 0.88 8.6 0.7 2.6 1 1 1 2 2 1 0 Interferon-related developmental regulator (IFRD) Peptidase_M22 PF00814.25 PIK41255.1 - 2.1e-55 188.3 0.0 3.9e-55 187.5 0.0 1.4 1 1 0 1 1 1 1 Glycoprotease family Methyltransf_12 PF08242.12 PIK41256.1 - 9.9e-20 71.1 0.0 7e-18 65.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK41256.1 - 6e-16 58.7 0.0 1e-15 58.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK41256.1 - 3.1e-14 53.4 0.0 6.7e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK41256.1 - 1.3e-11 45.0 0.0 4.1e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41256.1 - 6.1e-11 42.3 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK41256.1 - 7.5e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 PIK41256.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase domain CheR PF01739.18 PIK41256.1 - 0.0085 15.6 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain DUF3419 PF11899.8 PIK41256.1 - 0.034 13.3 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.17 PIK41256.1 - 0.036 13.3 0.0 0.071 12.3 0.0 1.5 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.17 PIK41256.1 - 0.037 13.5 0.0 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_28 PF02636.17 PIK41256.1 - 0.098 12.3 0.1 8.8 5.9 0.0 2.4 2 1 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Met_10 PF02475.16 PIK41256.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein RBB1NT PF08169.11 PIK41256.1 - 0.13 12.4 1.6 0.52 10.5 0.4 2.3 2 0 0 2 2 2 0 RBB1NT (NUC162) domain Glutaredoxin PF00462.24 PIK41256.1 - 0.14 12.4 0.1 4.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin RT_RNaseH PF17917.1 PIK41257.1 - 2.1e-25 89.0 0.0 3.1e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41257.1 - 8.3e-22 77.1 0.0 2.4e-21 75.7 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK41257.1 - 9.9e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain TEX12 PF15219.6 PIK41258.1 - 0.0045 17.3 0.3 0.0084 16.4 0.3 1.5 1 1 0 1 1 1 1 Testis-expressed 12 CRPV_capsid PF08762.10 PIK41258.1 - 0.056 13.1 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 CRPV capsid protein like Tnp_P_element PF12017.8 PIK41259.1 - 3.3e-23 82.3 0.1 5.2e-23 81.6 0.1 1.2 1 0 0 1 1 1 1 Transposase protein THAP PF05485.12 PIK41259.1 - 1.5e-14 54.7 2.4 4.4e-14 53.2 2.4 1.9 1 0 0 1 1 1 1 THAP domain Sirohm_synth_C PF14823.6 PIK41259.1 - 0.25 11.0 2.0 0.88 9.3 2.0 1.9 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal CARDB PF07705.11 PIK41260.1 - 3.1e-05 24.2 0.1 0.15 12.3 0.0 3.3 3 1 0 3 3 3 2 CARDB CARDB PF07705.11 PIK41261.1 - 7.8e-14 51.8 12.7 1.5e-08 34.8 0.1 5.2 5 0 0 5 5 5 4 CARDB Methyltransf_23 PF13489.6 PIK41263.1 - 1.8e-06 27.9 0.0 2.3e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Frizzled PF01534.17 PIK41264.1 - 3.9e-125 417.2 23.0 1.1e-124 415.8 23.0 1.7 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 PIK41264.1 - 2.1e-30 105.6 1.5 5.3e-30 104.3 1.5 1.7 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.11 PIK41264.1 - 0.00056 19.1 9.4 0.00098 18.3 9.0 1.6 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor FIIND PF13553.6 PIK41265.1 - 0.18 11.2 0.1 0.51 9.7 0.0 1.7 2 0 0 2 2 2 0 Function to find ANAPC4_WD40 PF12894.7 PIK41267.1 - 3.2e-07 30.6 0.4 0.0051 17.1 0.0 3.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK41267.1 - 0.016 16.1 1.9 7.4 7.6 0.2 4.1 3 1 1 4 4 4 0 WD domain, G-beta repeat Tub PF01167.18 PIK41268.1 - 3.8e-29 102.1 0.7 4.6e-29 101.9 0.7 1.2 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.8 PIK41268.1 - 0.0084 15.7 0.1 0.0084 15.7 0.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3527) RR_TM4-6 PF06459.12 PIK41268.1 - 3.8 7.3 8.4 4.8 6.9 8.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tmp39 PF10271.9 PIK41269.1 - 6.9e-137 457.0 36.2 1.3e-136 456.1 36.2 1.4 1 1 0 1 1 1 1 Putative transmembrane protein MATalpha_HMGbox PF04769.12 PIK41269.1 - 0.059 12.7 0.6 0.11 11.8 0.6 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box DUF1071 PF06378.11 PIK41270.1 - 0.014 15.0 0.2 0.026 14.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Ldl_recept_a PF00057.18 PIK41271.1 - 1.5e-47 159.5 102.2 2.2e-11 43.7 12.1 8.3 7 0 0 7 7 7 6 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK41271.1 - 8.1e-34 116.3 0.1 1.3e-14 54.5 0.3 4.0 3 0 0 3 3 3 3 CUB domain 7tm_1 PF00001.21 PIK41271.1 - 3.6e-28 98.6 12.7 6e-28 97.9 12.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK41271.1 - 2.6e-14 52.7 5.2 6.4e-09 35.4 1.3 3.0 1 1 2 3 3 3 3 Leucine rich repeat F5_F8_type_C PF00754.25 PIK41271.1 - 3.7e-09 36.8 0.1 1.1e-08 35.3 0.1 1.7 1 0 0 1 1 1 1 F5/8 type C domain LRR_4 PF12799.7 PIK41271.1 - 3.4e-05 24.1 1.6 0.0013 19.1 0.9 3.0 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) 7TM_GPCR_Srx PF10328.9 PIK41271.1 - 0.0059 16.3 8.6 0.012 15.3 8.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx FXa_inhibition PF14670.6 PIK41271.1 - 0.0077 16.5 7.6 0.0077 16.5 7.6 5.3 5 2 0 5 5 5 1 Coagulation Factor Xa inhibitory site LRR_1 PF00560.33 PIK41271.1 - 0.017 15.5 1.2 19 6.3 0.4 4.5 2 0 0 2 2 2 0 Leucine Rich Repeat Mpv17_PMP22 PF04117.12 PIK41271.1 - 1.4 9.2 4.6 0.42 10.9 0.1 2.4 2 0 0 2 2 2 0 Mpv17 / PMP22 family NACHT PF05729.12 PIK41272.1 - 1.2e-12 48.1 0.1 2.7e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 NACHT domain GTP_EFTU PF00009.27 PIK41272.1 - 0.094 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain EAV_GS PF01309.18 PIK41272.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein RVT_1 PF00078.27 PIK41273.1 - 5.5e-19 68.6 0.0 1.2e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.17 PIK41273.1 - 2.4e-15 56.6 0.4 3.6e-15 56.0 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 PIK41274.1 - 0.0097 16.0 0.2 0.025 14.6 0.2 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK41274.1 - 0.011 15.9 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin V-set domain Claudin_2 PF13903.6 PIK41274.1 - 0.019 14.7 0.3 0.032 14.0 0.3 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Shisa PF13908.6 PIK41274.1 - 0.034 14.4 1.2 0.034 14.4 1.2 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ig_3 PF13927.6 PIK41274.1 - 0.041 14.5 0.6 0.39 11.3 0.0 2.6 2 1 1 3 3 3 0 Immunoglobulin domain DUF2142 PF09913.9 PIK41274.1 - 0.087 11.7 0.4 0.11 11.3 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) TMEM154 PF15102.6 PIK41274.1 - 0.23 11.3 2.3 0.46 10.4 2.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family PAF-AH_p_II PF03403.13 PIK41276.1 - 2e-74 250.4 0.0 9.2e-43 146.2 0.0 2.0 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 PIK41276.1 - 1.9e-10 40.1 0.0 2.8e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 PIK41276.1 - 5.1e-07 29.5 0.0 7.4e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase PF07224.11 PIK41276.1 - 2.4e-06 26.8 0.0 0.0049 15.9 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase Peptidase_S9 PF00326.21 PIK41276.1 - 1.6e-05 24.5 0.0 0.00011 21.8 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 PIK41276.1 - 0.00012 21.4 0.0 0.075 12.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 PIK41276.1 - 0.0026 16.5 0.0 0.014 14.1 0.0 1.8 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 PIK41276.1 - 0.0084 16.7 0.0 0.011 16.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 PIK41276.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Borrelia_rep PF03183.13 PIK41278.1 - 0.14 12.2 1.2 19 5.5 0.0 2.4 2 0 0 2 2 2 0 Borrelia repeat protein MULE PF10551.9 PIK41279.1 - 1.2e-17 64.1 0.5 3.3e-17 62.7 0.1 2.0 2 0 0 2 2 2 1 MULE transposase domain ALS2CR8 PF15299.6 PIK41279.1 - 3.5e-17 63.0 3.0 6.2e-17 62.2 3.0 1.4 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Cnd1 PF12717.7 PIK41279.1 - 0.055 13.5 0.2 10 6.1 0.1 2.5 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Peptidase_C48 PF02902.19 PIK41280.1 - 0.00022 21.2 0.0 0.00035 20.5 0.0 1.3 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain NACHT PF05729.12 PIK41281.1 - 3.3e-09 36.9 0.0 4.6e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK41281.1 - 0.0077 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK41281.1 - 0.059 12.9 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK41281.1 - 0.075 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 GNT-I PF03071.15 PIK41282.1 - 1.9e-31 109.3 0.0 1.9e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.26 PIK41282.1 - 0.00012 22.0 0.0 0.00016 21.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 PIK41282.1 - 0.01 15.7 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Peptidase_S66C PF17676.1 PIK41282.1 - 0.088 13.4 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain GNT-I PF03071.15 PIK41283.1 - 9.4e-57 192.7 0.0 1e-56 192.5 0.0 1.0 1 0 0 1 1 1 1 GNT-I family RT_RNaseH PF17917.1 PIK41284.1 - 3.8e-35 120.3 0.0 1.6e-34 118.3 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41284.1 - 8.4e-34 115.6 0.0 3.2e-33 113.7 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41284.1 - 7.5e-28 97.6 0.0 1.2e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK41284.1 - 3.1e-22 78.4 0.1 6e-22 77.5 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain SCAN PF02023.17 PIK41284.1 - 1.5e-14 53.6 0.1 2.1e-12 46.7 0.0 2.6 2 0 0 2 2 2 1 SCAN domain zf-H2C2 PF09337.10 PIK41284.1 - 4.6e-06 26.8 0.1 9.8e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 PIK41284.1 - 0.13 12.5 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.23 PIK41284.1 - 0.16 12.1 1.4 0.35 11.0 1.4 1.6 1 0 0 1 1 1 0 Zinc knuckle OrfB_IS605 PF01385.19 PIK41284.1 - 8.3 6.7 8.2 4.6 7.5 4.8 2.2 2 0 0 2 2 2 0 Probable transposase Synaphin PF05835.12 PIK41285.1 - 5.5e-15 55.9 11.8 6.5e-15 55.7 11.8 1.0 1 0 0 1 1 1 1 Synaphin protein DUF1682 PF07946.14 PIK41285.1 - 0.097 11.9 5.9 0.11 11.6 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NARP1 PF12569.8 PIK41285.1 - 7 5.4 12.2 8.3 5.2 12.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RVT_1 PF00078.27 PIK41288.1 - 8.8e-23 81.0 0.0 1.1e-22 80.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gal-3-0_sulfotr PF06990.11 PIK41289.1 - 1e-37 130.0 1.7 1.3e-37 129.6 1.7 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase RVT_1 PF00078.27 PIK41290.1 - 1.3e-16 60.8 0.0 2.3e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK41290.1 - 0.00017 21.5 6.0 0.0041 17.1 1.1 2.4 2 0 0 2 2 2 2 Zinc knuckle Asp_protease PF09668.10 PIK41290.1 - 0.004 17.0 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease ZnuA PF01297.17 PIK41290.1 - 0.0097 15.3 0.2 0.015 14.7 0.2 1.3 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic PHD_4 PF16866.5 PIK41290.1 - 0.013 15.5 1.3 0.034 14.2 1.3 1.7 1 0 0 1 1 1 0 PHD-finger SlyX PF04102.12 PIK41290.1 - 0.048 14.3 1.7 0.13 12.9 1.7 1.7 1 0 0 1 1 1 0 SlyX Neil1-DNA_bind PF09292.10 PIK41290.1 - 0.051 13.6 0.8 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Endonuclease VIII-like 1, DNA bind Spuma_A9PTase PF03539.14 PIK41290.1 - 0.073 13.2 0.0 0.3 11.2 0.0 2.1 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_3 PF13917.6 PIK41290.1 - 0.22 11.5 7.2 0.27 11.2 1.6 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK41290.1 - 1 9.2 5.1 14 5.6 0.5 2.6 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK41291.1 - 3.9e-29 100.6 0.0 7.5e-29 99.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK41291.1 - 1.6e-28 99.1 0.0 4.4e-28 97.6 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41291.1 - 3.1e-18 66.1 0.0 5e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK41291.1 - 0.029 14.4 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK41292.1 - 1.2e-24 87.0 0.1 2.1e-24 86.3 0.1 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HRCT1 PF15758.5 PIK41292.1 - 0.23 12.5 0.2 0.23 12.5 0.2 2.3 2 1 1 3 3 3 0 Histidine-rich carboxyl terminus protein 1 Flu_M1_C PF08289.11 PIK41293.1 - 0.01 16.0 0.5 0.34 11.1 0.1 2.3 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain CHASE6_C PF17150.4 PIK41293.1 - 0.029 15.0 0.3 0.065 13.9 0.3 1.7 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain Arg_tRNA_synt_N PF03485.16 PIK41293.1 - 0.46 11.1 3.4 0.75 10.4 1.2 2.4 2 1 0 2 2 2 0 Arginyl tRNA synthetase N terminal domain CHASE6_C PF17150.4 PIK41294.1 - 0.012 16.3 1.1 0.034 14.8 0.5 2.1 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain Zona_pellucida PF00100.23 PIK41295.1 - 7.4e-41 140.6 4.5 1.3e-40 139.8 4.5 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain WD40 PF00400.32 PIK41296.1 - 5.6e-09 36.5 11.3 0.012 16.5 0.2 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat 7tm_1 PF00001.21 PIK41297.1 - 2.6e-25 89.2 9.1 3.3e-25 88.9 9.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK41297.1 - 7.8e-08 32.0 4.2 1e-07 31.6 4.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK41297.1 - 4.6e-07 29.7 7.8 1.6e-06 27.9 7.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx NPM1-C PF16276.5 PIK41297.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Nucleophosmin C-terminal domain SepSecS PF05889.13 PIK41298.1 - 6.5e-157 522.2 0.0 7.6e-157 522.0 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 PIK41298.1 - 5.9e-07 29.0 0.0 9e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 PIK41298.1 - 0.013 14.3 0.1 0.029 13.1 0.1 1.6 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Pkinase PF00069.25 PIK41299.1 - 3.5e-61 206.9 0.0 1.3e-60 205.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41299.1 - 1.8e-29 102.8 0.6 1.6e-20 73.5 0.1 2.1 1 1 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK41299.1 - 2.7e-06 26.6 0.0 3.7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK41299.1 - 0.0001 21.8 0.0 0.0028 17.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK41299.1 - 0.0014 18.0 0.0 0.003 17.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK41299.1 - 0.0032 17.4 0.6 0.19 11.6 0.2 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 PIK41299.1 - 0.0052 16.4 0.1 0.56 9.8 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 PIK41299.1 - 0.069 11.9 0.1 0.37 9.5 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase RIO1 PF01163.22 PIK41299.1 - 0.085 12.4 0.0 0.16 11.5 0.0 1.6 1 1 0 1 1 1 0 RIO1 family Pkinase_C PF00433.24 PIK41299.1 - 0.15 12.8 1.3 0.33 11.7 0.7 2.0 2 0 0 2 2 1 0 Protein kinase C terminal domain Seadorna_VP7 PF07387.11 PIK41299.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 V-set PF07686.17 PIK41300.1 - 6.8e-14 52.0 4.6 3.6e-06 27.1 0.0 4.7 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41300.1 - 1.1e-09 38.8 1.5 0.019 15.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain NACHT PF05729.12 PIK41300.1 - 1e-08 35.3 0.1 4e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain I-set PF07679.16 PIK41300.1 - 1.3e-08 34.8 1.1 0.062 13.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 PIK41300.1 - 4.3e-08 33.2 0.3 0.0025 17.9 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain Receptor_2B4 PF11465.8 PIK41300.1 - 8.3e-06 26.0 0.0 1.2 9.4 0.0 3.7 3 0 0 3 3 3 2 Natural killer cell receptor 2B4 SOTI PF17079.5 PIK41300.1 - 0.00088 19.6 0.0 1.2 9.6 0.0 2.8 2 0 0 2 2 2 2 Male-specific protein scotti AAA_7 PF12775.7 PIK41300.1 - 0.099 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region GAPT PF11770.8 PIK41300.1 - 2.2 8.2 5.9 29 4.5 0.1 3.7 4 0 0 4 4 4 0 GRB2-binding adapter (GAPT) V-set PF07686.17 PIK41301.1 - 0.0044 17.2 0.0 3 8.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK41302.1 - 7.4e-08 32.0 0.0 9.6e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK41303.1 - 1.3e-05 25.7 2.5 0.0059 17.2 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK41303.1 - 3.4e-05 24.0 0.4 0.00022 21.3 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK41303.1 - 0.00042 20.4 2.6 0.011 15.9 0.2 2.5 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK41303.1 - 0.0082 16.2 0.2 0.062 13.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain NACHT PF05729.12 PIK41304.1 - 3.2e-10 40.2 0.0 5.9e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 PIK41304.1 - 0.0013 19.2 0.0 0.59 10.6 0.0 2.6 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Sld3_N PF18523.1 PIK41304.1 - 0.56 10.3 2.8 3.3 7.9 0.2 2.5 2 0 0 2 2 2 0 Sld3 N-terminal domain Glyco_transf_29 PF00777.18 PIK41305.1 - 1.3e-31 110.0 0.5 2e-31 109.4 0.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Sulfatase PF00884.23 PIK41306.1 - 6.4e-64 216.3 0.1 8.1e-64 215.9 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK41306.1 - 8.7e-15 55.6 0.6 1.8e-14 54.6 0.6 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF229 PF02995.17 PIK41306.1 - 0.0013 17.4 0.0 0.0064 15.2 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 PIK41306.1 - 0.0035 17.0 0.1 0.048 13.2 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 PIK41306.1 - 0.061 12.4 0.0 0.095 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) CRM1_repeat_3 PF18787.1 PIK41306.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 CRM1 / Exportin repeat 3 MFS_1_like PF12832.7 PIK41307.1 - 5e-81 272.5 9.6 6.1e-81 272.2 9.6 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK41307.1 - 2.5e-27 95.8 17.2 3.4e-20 72.3 18.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 PIK41307.1 - 1.2e-15 57.3 10.9 1.3e-11 44.0 5.5 2.3 2 1 0 2 2 2 2 LacY proton/sugar symporter Nuc_H_symport PF03825.16 PIK41307.1 - 7.3e-10 38.4 9.3 7.1e-09 35.1 6.8 2.2 2 0 0 2 2 2 1 Nucleoside H+ symporter YtpI PF14007.6 PIK41307.1 - 0.018 15.1 2.8 0.048 13.8 0.4 2.7 3 0 0 3 3 3 0 YtpI-like protein MFS_3 PF05977.13 PIK41307.1 - 2.6 6.4 6.2 2 6.7 1.9 2.5 3 0 0 3 3 3 0 Transmembrane secretion effector AtuA PF07287.11 PIK41308.1 - 2.4e-109 365.3 0.0 3.5e-109 364.7 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Flavodoxin_2 PF02525.17 PIK41308.1 - 0.00084 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold SBP_bac_5 PF00496.22 PIK41308.1 - 0.18 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Asparaginase_2 PF01112.18 PIK41309.1 - 5.7e-49 166.8 9.1 4.1e-26 91.7 1.1 2.1 2 0 0 2 2 2 2 Asparaginase Prefoldin PF02996.17 PIK41309.1 - 0.0012 18.7 1.8 0.0029 17.5 0.1 2.2 2 0 0 2 2 2 1 Prefoldin subunit G_glu_transpept PF01019.21 PIK41309.1 - 0.0094 14.8 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase zf-CCHC PF00098.23 PIK41311.1 - 0.045 13.8 2.4 63 3.9 0.0 4.0 4 0 0 4 4 4 0 Zinc knuckle SAM_2 PF07647.17 PIK41312.1 - 0.00014 21.9 0.0 0.00031 20.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 PIK41312.1 - 0.00042 20.5 0.0 0.00091 19.4 0.0 1.6 1 0 0 1 1 1 1 Ste50p, sterile alpha motif Ig_3 PF13927.6 PIK41314.1 - 7.5e-37 125.8 1.1 2e-10 41.1 0.0 5.3 4 1 1 5 5 5 4 Immunoglobulin domain I-set PF07679.16 PIK41314.1 - 3.3e-29 100.8 0.0 3.6e-08 33.4 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK41314.1 - 2.8e-25 88.4 0.0 1.7e-06 28.2 0.0 4.7 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK41314.1 - 1.2e-21 76.7 0.0 5.2e-07 29.7 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.12 PIK41314.1 - 9e-10 38.5 0.0 0.004 17.2 0.0 3.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK41314.1 - 4.4e-08 33.3 2.0 0.13 12.4 0.0 5.5 5 2 1 6 6 6 2 Immunoglobulin V-set domain VWA_2 PF13519.6 PIK41314.1 - 0.0074 16.9 0.0 0.02 15.5 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain I-set PF07679.16 PIK41315.1 - 9.2e-108 352.6 0.0 3.5e-18 65.4 0.0 7.8 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK41315.1 - 1.1e-105 346.4 10.1 7.7e-17 61.7 0.0 7.1 7 0 0 7 7 7 7 Immunoglobulin domain Ig_2 PF13895.6 PIK41315.1 - 2.3e-80 265.0 0.4 9.2e-13 48.3 0.0 7.2 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 PIK41315.1 - 2.9e-52 174.8 0.0 3.5e-09 36.7 0.0 7.9 7 1 0 7 7 7 7 Immunoglobulin domain V-set PF07686.17 PIK41315.1 - 3e-33 114.3 12.6 0.00064 19.9 0.0 12.0 6 6 5 11 11 11 8 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK41315.1 - 6.2e-29 99.9 0.2 0.0023 18.0 0.0 7.4 7 0 0 7 7 7 7 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK41315.1 - 2.6e-18 66.2 0.0 0.0013 19.1 0.0 7.2 7 0 0 7 7 7 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 PIK41315.1 - 4.7e-15 55.7 0.0 0.96 9.9 0.0 7.7 7 1 0 7 7 7 4 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK41315.1 - 7.1e-15 55.0 0.0 0.66 10.3 0.0 6.7 6 0 0 6 6 6 5 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK41315.1 - 1.1e-10 41.5 0.1 0.19 11.8 0.0 5.5 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK41315.1 - 8.1e-10 38.1 0.0 0.3 10.7 0.0 6.2 6 0 0 6 6 6 2 Immunoglobulin domain V-set_CD47 PF08204.11 PIK41315.1 - 1.4e-08 34.8 2.9 0.48 10.4 0.0 6.3 5 3 2 7 7 7 2 CD47 immunoglobulin-like domain Ig_C17orf99 PF17736.1 PIK41315.1 - 1e-06 28.7 0.1 0.32 11.1 0.0 6.5 6 1 0 7 7 7 1 C17orf99 Ig domain DUF11 PF01345.18 PIK41315.1 - 0.01 16.1 2.8 0.054 13.8 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function DUF11 PKD_3 PF16820.5 PIK41315.1 - 0.075 12.8 0.4 51 3.7 0.0 4.2 5 0 0 5 5 5 0 PKD-like domain I-set PF07679.16 PIK41316.1 - 2.8e-07 30.5 0.0 3.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK41316.1 - 9.2e-07 29.4 0.2 1e-06 29.2 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK41316.1 - 4.9e-06 26.8 0.1 6.1e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK41316.1 - 0.00011 22.1 0.4 0.00019 21.5 0.4 1.4 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK41316.1 - 0.038 14.2 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK41317.1 - 1.1e-83 275.4 0.0 1.2e-16 60.5 0.0 5.9 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK41317.1 - 1.6e-77 256.1 1.0 1.8e-14 54.1 0.0 6.1 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 PIK41317.1 - 4e-53 177.7 0.1 9.8e-12 45.0 0.2 6.0 5 1 1 6 6 6 5 Immunoglobulin domain ig PF00047.25 PIK41317.1 - 6.6e-49 164.0 0.0 2.5e-10 40.4 0.0 5.9 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.17 PIK41317.1 - 1.8e-31 108.5 2.4 8.9e-06 25.9 0.2 10.1 7 4 0 7 7 7 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK41317.1 - 5.9e-16 58.3 0.9 0.00039 20.4 0.0 6.0 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK41317.1 - 1.8e-13 49.8 0.0 0.0017 17.8 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 PIK41317.1 - 1.5e-12 47.7 0.0 0.041 14.3 0.0 5.9 6 1 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK41317.1 - 1.5e-05 25.0 0.2 3.1 7.9 0.0 5.5 6 1 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK41317.1 - 5.5e-05 23.1 0.0 3.7 7.7 0.0 5.4 5 1 0 5 5 5 1 C17orf99 Ig domain V-set_CD47 PF08204.11 PIK41317.1 - 0.00011 22.2 0.0 28 4.7 0.0 5.3 4 1 1 5 5 5 0 CD47 immunoglobulin-like domain Receptor_2B4 PF11465.8 PIK41317.1 - 0.00028 21.0 0.0 1.1 9.5 0.0 4.3 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 Herpes_gE PF02480.16 PIK41317.1 - 0.05 12.3 0.0 4.2 6.0 0.0 3.3 4 0 0 4 4 4 0 Alphaherpesvirus glycoprotein E DUF11 PF01345.18 PIK41317.1 - 0.081 13.2 4.8 8 6.8 0.3 3.6 3 1 0 3 3 3 0 Domain of unknown function DUF11 I-set PF07679.16 PIK41318.1 - 3.3e-165 536.7 0.0 6.8e-16 58.1 0.0 12.0 12 0 0 12 12 12 12 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK41318.1 - 4.3e-153 498.3 20.8 3.9e-14 53.0 0.0 12.2 12 0 0 12 12 12 12 Immunoglobulin domain Ig_2 PF13895.6 PIK41318.1 - 1.6e-112 368.0 12.0 1.4e-11 44.6 0.0 12.1 11 1 1 12 12 12 11 Immunoglobulin domain ig PF00047.25 PIK41318.1 - 2.2e-95 313.0 3.3 1.3e-09 38.0 0.0 12.3 12 0 0 12 12 12 12 Immunoglobulin domain V-set PF07686.17 PIK41318.1 - 2.4e-50 169.2 20.0 0.00041 20.5 0.1 17.9 13 6 3 16 16 15 11 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK41318.1 - 6.9e-33 112.0 0.0 0.038 13.6 0.0 12.3 12 0 0 12 12 12 8 Immunoglobulin domain C2-set_2 PF08205.12 PIK41318.1 - 8.6e-32 109.1 8.0 0.0059 16.7 0.0 10.9 10 1 0 10 10 10 8 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK41318.1 - 6.1e-27 93.9 0.0 0.25 11.8 0.0 12.1 12 0 0 12 12 12 6 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK41318.1 - 8e-21 73.9 4.4 0.079 13.0 0.0 11.6 13 1 0 13 13 11 3 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK41318.1 - 3.1e-18 65.8 0.0 0.8 10.0 0.0 10.5 11 1 0 11 11 11 4 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 PIK41318.1 - 1.8e-16 60.3 0.1 1.7 8.9 0.0 9.8 11 0 0 11 11 11 3 Natural killer cell receptor 2B4 C2-set PF05790.15 PIK41318.1 - 6e-11 42.4 0.0 0.32 11.2 0.0 8.1 8 0 0 8 8 8 2 Immunoglobulin C2-set domain Ig_C17orf99 PF17736.1 PIK41318.1 - 8.3e-09 35.4 1.5 0.4 10.8 0.0 9.6 11 1 0 11 11 10 1 C17orf99 Ig domain Adeno_E3_CR1 PF02440.15 PIK41318.1 - 1.8e-07 30.8 2.6 0.59 9.9 0.0 7.3 8 0 0 8 8 7 1 Adenovirus E3 region protein CR1 Invasin_D3 PF09134.10 PIK41318.1 - 2.6e-05 24.5 7.3 0.17 12.2 0.0 5.6 7 0 0 7 7 7 1 Invasin, domain 3 V-set_CD47 PF08204.11 PIK41318.1 - 0.0002 21.3 8.5 4.3 7.3 0.0 8.3 8 1 0 8 8 8 1 CD47 immunoglobulin-like domain Herpes_gI PF01688.17 PIK41318.1 - 0.071 13.0 0.0 17 5.3 0.0 3.2 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein I zf-RRN7 PF11781.8 PIK41318.1 - 0.1 12.3 2.0 32 4.3 0.1 5.6 6 0 0 6 6 5 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Kunitz_BPTI PF00014.23 PIK41319.1 - 2.8e-17 62.7 12.7 2.8e-17 62.7 12.7 2.9 3 1 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Activin_recp PF01064.23 PIK41319.1 - 0.016 16.3 16.6 0.016 16.3 16.6 2.5 2 1 0 2 2 2 0 Activin types I and II receptor domain Globin PF00042.22 PIK41320.1 - 1.1e-21 77.5 0.4 1.4e-21 77.1 0.4 1.2 1 0 0 1 1 1 1 Globin IFN-gamma PF00714.17 PIK41320.1 - 0.0048 16.7 0.2 0.014 15.3 0.1 1.8 1 1 0 1 1 1 1 Interferon gamma LuxT_C PF18285.1 PIK41320.1 - 0.033 14.7 1.1 0.65 10.6 0.1 2.3 1 1 1 2 2 2 0 Tetracycline repressor LuxT C-terminal domain DAO PF01266.24 PIK41321.1 - 7.7e-31 107.9 0.0 8.9e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK41321.1 - 8.2e-06 25.3 0.0 8.6e-05 21.9 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK41321.1 - 1.4e-05 24.6 0.0 0.02 14.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK41321.1 - 2.9e-05 23.0 0.1 0.18 10.5 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 PIK41321.1 - 3.6e-05 23.0 0.0 0.0014 17.7 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 PIK41321.1 - 7.6e-05 22.9 0.0 0.00017 21.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 PIK41321.1 - 0.0019 17.3 0.0 0.02 14.0 0.0 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 PIK41321.1 - 0.0043 16.5 0.0 0.0085 15.5 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK41321.1 - 0.034 14.7 0.1 0.22 12.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK41321.1 - 0.043 13.1 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 PIK41321.1 - 0.073 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 PIK41321.1 - 0.16 11.6 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SNF2_N PF00176.23 PIK41322.1 - 2.5e-26 92.2 0.0 1.4e-24 86.5 0.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK41322.1 - 1.2e-20 73.9 0.1 5e-20 71.9 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 PIK41322.1 - 6.7e-06 25.5 0.1 2.3e-05 23.7 0.1 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 MAS20 PF02064.15 PIK41322.1 - 0.0019 18.3 4.0 0.0019 18.3 4.0 2.9 3 0 0 3 3 3 1 MAS20 protein import receptor TPR_1 PF00515.28 PIK41322.1 - 0.0043 16.8 0.2 0.0095 15.7 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat SWI2_SNF2 PF18766.1 PIK41322.1 - 0.0047 16.6 0.2 0.028 14.1 0.0 2.4 2 0 0 2 2 2 1 SWI2/SNF2 ATPase TPR_2 PF07719.17 PIK41322.1 - 0.17 12.1 0.1 0.47 10.7 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat FAD_binding_1 PF00667.20 PIK41324.1 - 3.4e-63 213.2 0.0 4.4e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 PIK41324.1 - 6.9e-18 65.2 0.0 3.2e-17 63.1 0.1 2.1 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 PIK41324.1 - 9.5e-08 32.7 0.0 7.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NO_synthase PF02898.15 PIK41325.1 - 8e-131 436.4 0.0 9.9e-131 436.1 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain Flavodoxin_1 PF00258.25 PIK41325.1 - 3.2e-25 89.0 0.0 6.2e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin Tox-REase-3 PF15647.6 PIK41325.1 - 0.18 12.1 0.2 0.35 11.2 0.2 1.5 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 3 FTA4 PF13093.6 PIK41326.1 - 0.0073 16.2 3.8 0.012 15.5 3.8 1.4 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DivIC PF04977.15 PIK41326.1 - 0.02 14.6 4.0 0.02 14.6 4.0 2.3 3 0 0 3 3 3 0 Septum formation initiator DUF2151 PF10221.9 PIK41326.1 - 0.031 12.9 2.4 0.038 12.6 2.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator TMF_TATA_bd PF12325.8 PIK41326.1 - 0.039 14.2 9.5 0.11 12.7 9.5 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 PIK41326.1 - 0.043 13.1 6.6 0.044 13.1 5.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) HTH_25 PF13413.6 PIK41326.1 - 0.051 13.4 0.2 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain V_ATPase_I PF01496.19 PIK41326.1 - 0.066 11.1 2.9 0.079 10.9 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cep57_MT_bd PF06657.13 PIK41326.1 - 0.069 13.6 5.5 1.6 9.3 0.4 2.7 1 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Golgin_A5 PF09787.9 PIK41326.1 - 0.12 11.8 9.8 0.2 11.1 9.8 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Lectin_N PF03954.14 PIK41326.1 - 0.41 10.4 3.0 0.97 9.2 3.0 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Prominin PF05478.11 PIK41326.1 - 1.9 6.4 3.9 2.4 6.0 3.9 1.1 1 0 0 1 1 1 0 Prominin DUF4140 PF13600.6 PIK41326.1 - 5.1 7.6 8.1 3.1 8.3 4.9 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4407 PF14362.6 PIK41326.1 - 5.4 6.3 5.8 3.2 7.0 3.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) IMUP PF15761.5 PIK41326.1 - 5.5 7.7 11.1 1.3 9.8 4.9 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein OPA3 PF07047.12 PIK41327.1 - 7.6e-45 151.7 0.0 9.8e-45 151.4 0.0 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Raf1_N PF18578.1 PIK41327.1 - 0.079 13.4 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain ABC_trans_CmpB PF06541.11 PIK41328.1 - 1.3e-07 32.0 11.4 1.6e-07 31.7 11.4 1.1 1 0 0 1 1 1 1 Putative ABC-transporter type IV Death PF00531.22 PIK41329.1 - 3e-15 56.2 1.7 3.4e-15 56.0 1.7 1.1 1 0 0 1 1 1 1 Death domain HTH_3 PF01381.22 PIK41329.1 - 0.034 14.2 0.0 0.13 12.4 0.0 2.0 1 1 1 2 2 2 0 Helix-turn-helix YdaS_antitoxin PF15943.5 PIK41329.1 - 0.074 12.9 0.0 3.8 7.5 0.0 2.2 1 1 1 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Exo_endo_phos_2 PF14529.6 PIK41330.1 - 3e-07 30.3 0.0 6.2e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Clusterin PF01093.17 PIK41330.1 - 0.049 12.7 2.5 0.17 10.9 0.9 1.9 1 1 0 2 2 2 0 Clusterin Death PF00531.22 PIK41331.1 - 8.7e-13 48.3 0.0 1.2e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Death domain Dehydratase_LU PF02286.15 PIK41331.1 - 0.032 12.8 0.0 0.036 12.7 0.0 1.0 1 0 0 1 1 1 0 Dehydratase large subunit Death PF00531.22 PIK41332.1 - 5e-08 33.0 0.0 7.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Death domain DUF5028 PF16431.5 PIK41332.1 - 0.12 12.4 0.0 0.14 12.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) DUF563 PF04577.14 PIK41333.1 - 6.2e-19 69.0 0.0 1.2e-18 68.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) EF-hand_7 PF13499.6 PIK41334.1 - 1.2e-08 35.3 12.3 0.00012 22.4 0.4 5.8 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_13 PF17958.1 PIK41334.1 - 7.5e-07 28.9 0.1 1.5e-05 24.7 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_6 PF13405.6 PIK41334.1 - 3e-05 23.6 11.1 1.2 9.3 0.0 5.5 6 0 0 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 PIK41334.1 - 3.2e-05 23.2 6.0 0.26 10.9 0.0 5.3 6 0 0 6 6 6 2 EF hand EF-hand_5 PF13202.6 PIK41334.1 - 0.027 14.0 0.5 0.16 11.5 0.0 2.5 3 0 0 3 3 3 0 EF hand Rad21_Rec8 PF04824.16 PIK41334.1 - 0.13 11.6 0.3 22 4.4 0.0 2.9 3 0 0 3 3 3 0 Conserved region of Rad21 / Rec8 like protein EF-hand_7 PF13499.6 PIK41335.1 - 0.032 14.7 0.3 0.069 13.6 0.2 1.6 1 1 0 1 1 1 0 EF-hand domain pair GBP PF02263.19 PIK41336.1 - 7.7e-34 117.1 0.0 1.5e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 PIK41336.1 - 1.2e-08 34.7 5.0 0.00023 20.7 2.8 2.3 2 0 0 2 2 2 2 Guanylate-binding protein, C-terminal domain AAA_22 PF13401.6 PIK41336.1 - 0.048 13.9 0.0 8.8 6.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain CobU PF02283.16 PIK41336.1 - 0.089 12.3 0.1 0.3 10.6 0.0 1.9 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Hep_59 PF07052.11 PIK41336.1 - 0.14 13.0 2.7 0.28 11.9 2.7 1.5 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 Fibrinogen_C PF00147.18 PIK41337.1 - 6e-45 153.7 0.8 8e-45 153.3 0.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK41337.1 - 9.2e-06 25.5 9.1 9.2e-06 25.5 9.1 2.4 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK41337.1 - 2.4e-05 24.4 12.1 2.4e-05 24.4 12.1 2.9 2 1 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK41337.1 - 5 7.3 15.3 0.57 10.3 8.8 2.8 3 0 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK41338.1 - 4.8e-27 95.2 0.7 5.6e-27 95.0 0.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain GLTP PF08718.11 PIK41339.1 - 6.8e-20 71.9 0.0 1.5e-19 70.7 0.0 1.5 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) DUF5055 PF16478.5 PIK41339.1 - 0.12 12.7 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5055) zf-H2C2_2 PF13465.6 PIK41340.1 - 5.3e-21 74.1 51.9 7.2e-09 35.7 0.8 10.1 10 1 0 10 10 10 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41340.1 - 1.4e-17 62.8 61.1 0.018 15.8 0.8 9.5 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK41340.1 - 6.1e-14 51.6 65.3 0.022 15.2 0.7 9.9 9 0 0 9 9 9 8 Zinc finger, C2H2 type PRP21_like_P PF12230.8 PIK41340.1 - 0.0027 17.6 8.4 0.11 12.3 0.3 3.5 3 1 0 3 3 3 2 Pre-mRNA splicing factor PRP21 like protein zf_UBZ PF18439.1 PIK41340.1 - 0.0041 16.7 28.3 0.56 9.8 0.1 7.6 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger Zds_C PF08632.10 PIK41340.1 - 0.093 12.5 1.1 3.6 7.4 0.0 2.6 2 0 0 2 2 2 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term zf-CHCC PF10276.9 PIK41340.1 - 0.15 12.2 0.1 0.15 12.2 0.1 5.7 8 0 0 8 8 6 0 Zinc-finger domain DZR PF12773.7 PIK41340.1 - 0.18 11.9 27.6 5.4 7.1 0.2 5.2 3 1 0 3 3 2 0 Double zinc ribbon zf-BED PF02892.15 PIK41340.1 - 1.4 9.0 62.5 2.3 8.3 1.9 9.1 3 2 6 9 9 9 0 BED zinc finger Lactococcin_972 PF09683.10 PIK41340.1 - 1.9 9.1 0.0 1.9 9.1 0.0 2.9 3 0 0 3 3 3 0 Bacteriocin (Lactococcin_972) zf-C2H2_2 PF12756.7 PIK41340.1 - 2.6 8.4 44.3 0.85 10.0 1.3 6.9 1 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) YhfH PF14149.6 PIK41340.1 - 2.7 8.1 15.6 11 6.1 0.3 5.6 5 0 0 5 5 5 0 YhfH-like protein FYVE PF01363.21 PIK41340.1 - 2.9 8.1 42.9 2.7 8.2 7.4 5.6 2 2 2 4 4 4 0 FYVE zinc finger zinc_ribbon_15 PF17032.5 PIK41340.1 - 3.5 8.4 33.6 1.8 9.4 1.2 5.1 2 2 3 5 5 5 0 zinc-ribbon family Zf_RING PF16744.5 PIK41340.1 - 5.1 7.3 34.4 5.8 7.1 0.8 7.4 2 2 4 7 7 7 0 KIAA1045 RING finger zf-C2H2_jaz PF12171.8 PIK41340.1 - 5.6 7.4 42.5 1.1 9.7 0.2 8.9 9 1 0 9 9 9 0 Zinc-finger double-stranded RNA-binding SR-25 PF10500.9 PIK41341.1 - 0.0063 16.1 2.9 0.0063 16.1 2.9 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Cyclin_C PF02984.19 PIK41341.1 - 0.14 12.2 1.4 9.3 6.4 0.6 2.4 2 0 0 2 2 2 0 Cyclin, C-terminal domain RNA_pol_L_2 PF13656.6 PIK41342.1 - 4.5e-28 96.8 0.0 5.9e-28 96.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 PIK41342.1 - 5.2e-12 45.0 0.0 7.5e-12 44.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain IML1 PF12257.8 PIK41343.1 - 5.6e-14 51.9 0.1 9e-14 51.3 0.1 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 IML1 PF12257.8 PIK41344.1 - 7.4e-61 205.8 0.3 9e-61 205.5 0.3 1.0 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 PDH PF02153.17 PIK41344.1 - 0.092 11.7 0.1 0.16 10.9 0.0 1.4 1 1 0 1 1 1 0 Prephenate dehydrogenase DUF2383 PF09537.10 PIK41344.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) zf-C3HC4 PF00097.25 PIK41345.1 - 2.6e-10 40.0 7.4 2.6e-10 40.0 7.4 3.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK41345.1 - 1.9e-09 37.4 4.8 1.9e-09 37.4 4.8 2.8 2 1 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK41345.1 - 1e-08 34.9 5.1 1e-08 34.9 5.1 3.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK41345.1 - 2.1e-07 30.7 8.9 2.1e-07 30.7 8.9 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK41345.1 - 8.8e-07 28.8 6.6 8.8e-07 28.8 6.6 3.9 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK41345.1 - 9.7e-07 29.0 6.9 9.7e-07 29.0 6.9 4.6 5 1 0 5 5 4 1 Ring finger domain Prok-RING_4 PF14447.6 PIK41345.1 - 8.4e-06 25.6 6.5 8.4e-06 25.6 6.5 3.3 3 0 0 3 3 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK41345.1 - 9.4e-06 25.7 8.6 9.4e-06 25.7 8.6 3.4 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK41345.1 - 0.0001 22.4 9.8 0.0001 22.4 9.8 4.7 5 0 0 5 5 5 2 B-box zinc finger Peptidase_S46 PF10459.9 PIK41345.1 - 0.016 13.9 9.0 0.023 13.4 9.0 1.2 1 0 0 1 1 1 0 Peptidase S46 zf-RING_11 PF17123.5 PIK41345.1 - 0.017 14.8 2.2 0.017 14.8 2.2 3.4 3 1 1 4 4 4 0 RING-like zinc finger DUF3685 PF12452.8 PIK41345.1 - 0.17 11.6 4.3 0.21 11.2 2.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3685) DUF4407 PF14362.6 PIK41345.1 - 5.2 6.3 12.6 8.1 5.7 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cor1 PF04803.12 PIK41345.1 - 5.5 7.2 31.5 5.8 7.1 13.4 2.5 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region MMM1 PF10296.9 PIK41346.1 - 0.018 14.1 2.8 0.025 13.7 2.8 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 RhoGAP PF00620.27 PIK41346.1 - 0.071 12.9 1.8 0.11 12.3 1.8 1.3 1 0 0 1 1 1 0 RhoGAP domain Exonuc_VII_L PF02601.15 PIK41346.1 - 0.14 11.7 4.4 0.18 11.4 4.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SATase_N PF06426.14 PIK41346.1 - 0.14 12.5 1.4 5.3 7.5 0.1 2.3 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal NABP PF07990.12 PIK41346.1 - 0.15 11.6 5.2 0.47 9.9 5.2 1.8 1 1 0 1 1 1 0 Nucleic acid binding protein NABP DUF87 PF01935.17 PIK41346.1 - 0.44 10.6 4.5 1.4 9.0 4.8 1.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_11 PF13086.6 PIK41346.1 - 0.7 9.6 9.4 1.1 9.0 9.4 1.2 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 PIK41346.1 - 2 7.7 6.4 2.7 7.3 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C3HC4_2 PF13923.6 PIK41347.1 - 5.1e-09 35.8 8.7 5.1e-09 35.8 8.7 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK41347.1 - 1.1e-08 34.8 8.9 1.1e-08 34.8 8.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK41347.1 - 2e-08 34.1 6.8 2e-08 34.1 6.8 2.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK41347.1 - 9.6e-08 32.2 8.2 9.6e-08 32.2 8.2 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK41347.1 - 2.1e-07 30.7 7.9 2.1e-07 30.7 7.9 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK41347.1 - 1.2e-06 28.6 9.1 1.2e-06 28.6 9.1 3.6 3 2 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK41347.1 - 5.1e-05 23.1 6.9 5.1e-05 23.1 6.9 3.8 3 1 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK41347.1 - 7.4e-05 22.8 23.6 0.00046 20.3 9.1 4.3 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK41347.1 - 8.6e-05 22.3 8.7 8.6e-05 22.3 8.7 3.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 PIK41347.1 - 0.0082 16.0 3.6 0.0082 16.0 3.6 2.5 3 0 0 3 3 3 1 zf-RING of BARD1-type protein Fibrinogen_C PF00147.18 PIK41348.1 - 1.5e-44 152.4 15.7 3e-44 151.5 15.7 1.5 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK41348.1 - 0.00022 21.4 8.6 0.00022 21.4 8.6 2.8 2 1 0 2 2 2 1 EGF domain Tme5_EGF_like PF09064.10 PIK41348.1 - 0.023 14.6 4.8 0.023 14.6 4.8 2.3 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like PAC3 PF10178.9 PIK41349.1 - 0.054 13.6 0.0 0.098 12.8 0.0 1.5 1 1 0 1 1 1 0 Proteasome assembly chaperone 3 S-methyl_trans PF02574.16 PIK41350.1 - 7e-12 45.7 1.0 1.8e-10 41.1 0.1 2.0 1 1 1 2 2 2 2 Homocysteine S-methyltransferase Fibrinogen_C PF00147.18 PIK41351.1 - 6.8e-45 153.6 9.1 9.6e-45 153.1 9.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF5313 PF17240.2 PIK41353.1 - 0.1 13.0 0.0 48 4.4 0.0 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5313) Pkinase_Tyr PF07714.17 PIK41354.1 - 9.4e-20 71.0 0.0 9.9e-20 70.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41354.1 - 5.6e-06 25.9 0.0 5.6e-06 25.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41355.1 - 1.4e-81 273.6 0.0 1.9e-81 273.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41355.1 - 1.6e-34 119.5 0.0 2.4e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF4381 PF14316.6 PIK41355.1 - 0.042 14.1 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Potyvirid-P3 PF13608.6 PIK41355.1 - 0.073 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein EphA2_TM PF14575.6 PIK41355.1 - 0.082 13.8 0.7 0.19 12.7 0.2 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PRIMA1 PF16101.5 PIK41355.1 - 0.41 10.7 2.6 0.68 10.0 1.8 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 PMP1_2 PF08114.11 PIK41355.1 - 0.46 10.3 5.5 0.41 10.4 3.5 1.9 2 0 0 2 2 2 0 ATPase proteolipid family Pkinase_Tyr PF07714.17 PIK41356.1 - 2.5e-82 276.0 0.0 3.2e-82 275.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41356.1 - 9.5e-35 120.2 0.0 1.4e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH_6_hur PF04655.14 PIK41356.1 - 0.16 11.4 0.0 2.7 7.3 0.0 2.3 3 0 0 3 3 3 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Sushi PF00084.20 PIK41359.1 - 0.0042 17.6 0.0 0.0096 16.5 0.0 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK41359.1 - 0.013 16.0 0.0 0.032 14.8 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain RGM_C PF06534.13 PIK41359.1 - 0.13 11.8 0.4 0.22 11.0 0.4 1.3 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) C-terminus Ycf34 PF10718.9 PIK41359.1 - 0.18 12.5 0.0 0.34 11.6 0.0 1.5 1 0 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 Glyco_transf_7N PF13733.6 PIK41360.1 - 2.6e-17 62.7 0.0 6.1e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 PIK41360.1 - 2.5e-15 55.9 0.7 6.5e-15 54.6 0.7 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase TPR_12 PF13424.6 PIK41361.1 - 5.8e-06 26.5 0.3 0.00034 20.8 0.0 3.1 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK41361.1 - 9.7e-06 25.3 0.2 0.0015 18.4 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41361.1 - 1.7e-05 24.4 0.1 0.0058 16.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK41361.1 - 3.6e-05 23.4 0.0 0.044 13.5 0.0 3.3 3 0 0 3 3 3 1 TPR repeat SNAP PF14938.6 PIK41361.1 - 5.5e-05 22.7 0.3 7.8e-05 22.2 0.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_21 PF09976.9 PIK41361.1 - 0.00047 19.9 0.1 0.0028 17.4 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 PIK41361.1 - 0.0025 17.3 1.4 0.0055 16.1 1.2 1.7 1 1 0 1 1 1 1 MalT-like TPR region TPR_14 PF13428.6 PIK41361.1 - 0.006 17.3 0.1 0.19 12.6 0.0 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41361.1 - 0.0062 16.5 1.2 0.69 10.1 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK41361.1 - 0.0063 17.1 0.2 1.2 9.9 0.1 3.3 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41361.1 - 0.012 15.8 0.1 1.4 9.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK41361.1 - 0.023 14.4 0.0 0.21 11.3 0.0 2.2 1 1 1 2 2 2 0 26S proteasome subunit RPN7 NDT80_PhoG PF05224.12 PIK41363.1 - 0.021 15.0 0.1 0.025 14.8 0.1 1.2 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family Fe_dep_repress PF01325.19 PIK41363.1 - 0.15 12.3 0.0 19 5.6 0.0 2.2 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain rve PF00665.26 PIK41364.1 - 1.2e-10 41.6 0.1 4e-09 36.7 0.0 2.3 1 1 1 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41364.1 - 5.1e-07 29.7 1.0 8.9e-07 28.9 1.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK41364.1 - 4.5e-05 23.1 0.0 9e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK41365.1 - 4.2e-37 126.2 0.0 6.7e-37 125.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK41365.1 - 5.9e-36 122.9 0.0 9.5e-36 122.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_pol_viral_C PF00336.18 PIK41365.1 - 0.035 13.5 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RT_RNaseH PF17917.1 PIK41366.1 - 3.5e-28 98.0 0.0 4.6e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41366.1 - 1.8e-22 79.2 0.0 3.8e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41367.1 - 2.4e-30 105.7 0.0 3.1e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tnp_P_element PF12017.8 PIK41368.1 - 1.5e-25 89.9 0.0 1.9e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Transposase protein Sirohm_synth_C PF14823.6 PIK41368.1 - 0.26 10.9 1.7 0.71 9.6 1.7 1.7 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal RT_RNaseH PF17917.1 PIK41369.1 - 2.6e-33 114.4 0.1 7.8e-33 112.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41369.1 - 6.1e-32 109.6 0.1 1.3e-31 108.5 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK41369.1 - 2.2e-19 69.8 0.0 5e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK41369.1 - 1.8e-15 57.1 0.0 3.8e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK41369.1 - 1.7e-14 53.7 0.0 3.7e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK41369.1 - 2.7e-05 24.3 0.0 6.9e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK41369.1 - 0.024 14.4 0.3 0.067 13.0 0.3 1.8 1 0 0 1 1 1 0 Integrase core domain rve PF00665.26 PIK41370.1 - 1.9e-05 24.8 0.1 7.1e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK41370.1 - 0.00023 20.9 0.0 0.00056 19.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain IF2_N PF04760.15 PIK41370.1 - 0.042 13.7 0.1 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region RA PF00788.23 PIK41371.1 - 1e-14 54.9 0.1 1.5e-09 38.4 0.1 3.1 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.17 PIK41371.1 - 2.6e-11 43.5 0.6 7.8e-08 32.3 0.1 2.9 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK41371.1 - 7.6e-10 39.1 1.0 6.5e-08 32.9 0.1 2.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) EF-G-binding_N PF07299.11 PIK41371.1 - 6.2 7.4 6.4 1.9 9.1 0.9 3.1 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal SH2_2 PF14633.6 PIK41372.1 - 2e-83 279.0 3.3 4.6e-83 277.9 3.3 1.6 1 0 0 1 1 1 1 SH2 domain YqgF PF14639.6 PIK41372.1 - 8.9e-38 129.4 0.0 3.1e-37 127.7 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 PIK41372.1 - 5.1e-36 123.2 0.1 1.1e-35 122.1 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 PIK41372.1 - 2.6e-22 79.4 1.1 7.6e-22 77.9 1.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 S1 PF00575.23 PIK41372.1 - 2.1e-09 37.6 0.0 1.2e-08 35.2 0.0 2.4 1 0 0 1 1 1 1 S1 RNA binding domain SPT6_acidic PF14632.6 PIK41372.1 - 9.8e-09 35.7 20.6 9.8e-09 35.7 20.6 7.3 4 2 2 6 6 4 1 Acidic N-terminal SPT6 Tex_N PF09371.10 PIK41372.1 - 4.6e-08 33.0 2.7 0.00097 18.9 0.1 3.5 2 1 0 2 2 2 2 Tex-like protein N-terminal domain HHH_9 PF17674.1 PIK41372.1 - 3.4e-07 31.1 0.2 2.3e-06 28.4 0.2 2.6 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 PIK41372.1 - 1e-05 26.0 0.1 2.7e-05 24.6 0.1 1.7 1 0 0 1 1 1 1 Tex protein YqgF-like domain SH2 PF00017.24 PIK41372.1 - 2.3e-05 24.4 0.0 0.00015 21.8 0.0 2.3 2 0 0 2 2 2 1 SH2 domain HHH_3 PF12836.7 PIK41372.1 - 0.0031 17.7 0.0 0.0067 16.7 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Torsin PF06309.11 PIK41373.1 - 3.1e-41 140.4 0.6 7.4e-41 139.2 0.6 1.6 1 0 0 1 1 1 1 Torsin AAA PF00004.29 PIK41373.1 - 0.00033 21.1 0.0 0.00057 20.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK41373.1 - 0.00072 19.6 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 PIK41373.1 - 0.018 15.0 0.2 0.06 13.3 0.2 1.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 PIK41373.1 - 0.051 13.3 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.14 PIK41373.1 - 0.056 13.6 0.0 0.27 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK41373.1 - 0.083 13.2 0.1 1.9 8.8 0.1 2.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 PIK41373.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Torsin PF06309.11 PIK41374.1 - 1.6e-31 109.1 0.4 3.1e-31 108.1 0.4 1.5 1 0 0 1 1 1 1 Torsin Fe-S_biosyn PF01521.20 PIK41375.1 - 1.5e-20 73.5 0.1 1.7e-20 73.3 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Filament PF00038.21 PIK41376.1 - 6.4e-17 62.1 63.9 7.1e-16 58.7 63.9 2.0 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 PIK41376.1 - 3.2e-13 50.0 0.0 7.7e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Lamin Tail Domain DUF2935 PF11155.8 PIK41376.1 - 0.36 11.2 5.2 16 5.8 2.4 3.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) FPP PF05911.11 PIK41376.1 - 2.8 6.0 53.4 2.9 6.0 29.1 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Peptidase_S49_N PF08496.10 PIK41380.1 - 0.64 10.1 6.6 0.67 10.0 4.2 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CLASP_N PF12348.8 PIK41381.1 - 9.3e-11 41.7 0.4 8.4e-07 28.8 0.1 2.2 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 PIK41381.1 - 3.7e-06 26.7 0.2 0.0047 17.1 0.0 4.6 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 PIK41381.1 - 0.00014 22.2 0.2 0.16 12.4 0.1 4.0 4 1 1 5 5 5 1 HEAT repeats Cnd1 PF12717.7 PIK41381.1 - 0.00051 20.1 1.2 0.41 10.7 0.1 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK41381.1 - 0.0049 15.5 0.3 0.0089 14.6 0.1 1.6 2 0 0 2 2 2 1 Adaptin N terminal region HEAT_EZ PF13513.6 PIK41381.1 - 0.0066 16.9 0.3 0.25 11.9 0.1 3.1 2 1 1 3 3 3 1 HEAT-like repeat Tti2 PF10521.9 PIK41381.1 - 0.15 11.6 0.7 0.95 8.9 0.0 2.5 2 2 2 4 4 4 0 Tti2 family HEAT PF02985.22 PIK41382.1 - 1.2e-10 40.7 0.4 0.0076 16.4 0.0 4.1 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 PIK41382.1 - 7e-08 32.8 0.0 0.0052 17.1 0.0 4.0 4 0 0 4 4 4 2 HEAT repeats CLASP_N PF12348.8 PIK41382.1 - 1.2e-07 31.6 0.1 0.0094 15.5 0.1 2.4 2 0 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.6 PIK41382.1 - 8e-06 26.2 0.1 0.00073 20.0 0.1 3.1 3 0 0 3 3 3 1 HEAT-like repeat TAN PF11640.8 PIK41382.1 - 0.0011 19.2 0.1 2.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Telomere-length maintenance and DNA damage repair DUF4042 PF13251.6 PIK41382.1 - 0.13 11.9 0.0 35 4.1 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4042) Cnd1 PF12717.7 PIK41382.1 - 0.15 12.1 0.0 12 5.9 0.0 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK41382.1 - 0.19 12.3 0.0 24 5.6 0.0 2.7 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK41383.1 - 3.2e-08 33.4 1.6 1.3e-06 28.1 0.1 3.1 3 1 0 3 3 3 1 CLASP N terminal HEAT PF02985.22 PIK41383.1 - 5.7e-05 23.0 0.2 2.9 8.4 0.0 4.1 3 0 0 3 3 3 2 HEAT repeat RTP1_C1 PF10363.9 PIK41383.1 - 0.00011 22.3 2.2 0.66 10.2 0.1 4.1 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 PIK41383.1 - 0.0013 19.1 0.0 1.3 9.5 0.0 3.3 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 PIK41383.1 - 0.018 15.5 0.0 20 5.8 0.0 3.6 3 0 0 3 3 3 0 HEAT-like repeat MMS19_N PF14500.6 PIK41383.1 - 0.1 12.2 1.2 5.4 6.5 0.0 3.3 2 1 1 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II RVT_1 PF00078.27 PIK41384.1 - 9e-33 113.6 0.3 6.4e-32 110.9 0.2 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK41385.1 - 5.4e-25 87.9 0.0 6.4e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK41385.1 - 1.1e-06 28.3 0.1 2.4e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3453 PF11935.8 PIK41386.1 - 2.9e-20 72.9 0.6 2.9e-20 72.9 0.6 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3453) Symplekin_C PF12295.8 PIK41387.1 - 3e-69 232.9 4.5 3e-69 232.9 4.5 2.6 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 PIK41387.1 - 1e-19 71.1 0.2 3.4e-18 66.1 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) PID PF00640.23 PIK41388.1 - 1.9e-18 66.9 0.6 4.9e-18 65.5 0.6 1.8 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SAM_2 PF07647.17 PIK41388.1 - 1e-14 54.4 0.1 2.3e-09 37.2 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK41388.1 - 6.9e-13 48.8 0.0 9.4e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID_2 PF14719.6 PIK41388.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF563 PF04577.14 PIK41389.1 - 1.5e-16 61.2 0.0 2.9e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) RVT_1 PF00078.27 PIK41390.1 - 2.5e-28 99.1 0.1 4.5e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Fibrinogen_C PF00147.18 PIK41391.1 - 2e-71 240.3 5.1 2.5e-71 240.0 5.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK41391.1 - 0.063 12.6 0.1 0.082 12.2 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain HisG_C PF08029.11 PIK41392.1 - 0.0068 16.5 0.1 0.24 11.6 0.0 2.4 2 0 0 2 2 2 1 HisG, C-terminal domain DED PF01335.21 PIK41392.1 - 0.0071 16.6 0.0 6.2 7.2 0.0 2.6 2 0 0 2 2 2 2 Death effector domain zf-DNL PF05180.12 PIK41392.1 - 0.51 10.3 2.2 2.3 8.2 0.2 2.5 2 0 0 2 2 2 0 DNL zinc finger LRAT PF04970.13 PIK41393.1 - 8.5e-07 29.3 0.4 2.5e-06 27.8 0.4 1.9 1 1 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK41393.1 - 2.3 8.1 5.5 0.82 9.5 0.2 2.7 3 0 0 3 3 3 0 PPPDE putative peptidase domain FAM53 PF15242.6 PIK41396.1 - 1.2e-13 51.6 8.9 1.2e-07 31.9 1.9 2.2 2 0 0 2 2 2 2 Family of FAM53 Zip PF02535.22 PIK41397.1 - 2.6e-56 191.3 0.9 3.4e-56 190.9 0.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter U1snRNP70_N PF12220.8 PIK41398.1 - 0.089 13.4 7.2 0.16 12.6 7.2 1.3 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4407 PF14362.6 PIK41398.1 - 0.58 9.5 5.2 0.57 9.5 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 PIK41398.1 - 2.2 7.0 3.1 2 7.1 3.1 1.2 1 0 0 1 1 1 0 Presenilin ETRAMP PF09716.10 PIK41399.1 - 9.6e-06 25.6 1.4 2.6e-05 24.2 1.4 1.7 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Ureide_permease PF07168.11 PIK41399.1 - 0.017 13.9 0.1 0.022 13.5 0.1 1.1 1 0 0 1 1 1 0 Ureide permease Gastrin PF00918.17 PIK41400.1 - 0.33 11.9 8.7 0.13 13.3 6.1 1.7 2 0 0 2 2 2 0 Gastrin/cholecystokinin family U79_P34 PF03064.16 PIK41400.1 - 0.48 9.8 17.1 0.64 9.3 17.1 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 GvpL_GvpF PF06386.11 PIK41400.1 - 4.1 7.2 10.7 6.7 6.6 10.7 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Sel1 PF08238.12 PIK41401.1 - 3.9e-24 84.6 16.1 3.3e-05 24.4 0.0 6.9 7 0 0 7 7 7 5 Sel1 repeat TPR_2 PF07719.17 PIK41401.1 - 0.0027 17.7 7.0 0.028 14.5 0.5 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK41401.1 - 0.012 15.9 0.1 0.14 12.4 0.1 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK41401.1 - 0.019 15.5 0.3 0.29 11.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41401.1 - 0.021 15.0 9.5 0.19 12.0 0.2 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41401.1 - 0.1 12.4 6.7 1.3 9.0 0.6 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK41401.1 - 0.14 12.5 2.9 1.1 9.5 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK41401.1 - 0.16 12.7 5.0 2.5 8.9 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SH2 PF00017.24 PIK41402.1 - 5.7e-09 36.0 0.1 1.1e-08 35.1 0.1 1.4 1 0 0 1 1 1 1 SH2 domain Lipase PF00151.19 PIK41403.1 - 4.2e-42 144.6 0.0 3.2e-41 141.8 0.0 1.9 1 1 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 PIK41403.1 - 0.0041 17.8 0.2 0.005 17.5 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family 7tm_1 PF00001.21 PIK41404.1 - 9.3e-14 51.4 3.8 1.2e-13 51.0 3.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK41404.1 - 1e-05 25.5 1.9 1.2e-05 25.2 1.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK41404.1 - 0.00078 18.9 4.6 0.001 18.5 4.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK41404.1 - 0.0014 18.3 8.2 0.0019 17.8 8.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx NnrS PF05940.12 PIK41404.1 - 0.0045 16.4 6.2 0.0056 16.1 6.2 1.1 1 0 0 1 1 1 1 NnrS protein 7tm_2 PF00002.24 PIK41405.1 - 4.2e-39 134.3 23.5 6.2e-39 133.8 23.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK41405.1 - 1.1e-09 38.5 3.2 2e-09 37.6 3.2 1.5 1 0 0 1 1 1 1 Hormone receptor domain Sushi PF00084.20 PIK41405.1 - 0.014 16.0 2.0 0.034 14.7 2.0 1.8 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) Neuro_bHLH PF12533.8 PIK41406.1 - 4.2e-19 70.0 4.2 4.2e-19 70.0 4.2 2.7 2 1 0 2 2 2 1 Neuronal helix-loop-helix transcription factor HLH PF00010.26 PIK41406.1 - 4.1e-15 55.5 1.4 4.1e-15 55.5 1.4 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain McrBC PF10117.9 PIK41406.1 - 0.095 11.8 0.3 0.15 11.1 0.3 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component GRIP PF01465.20 PIK41407.1 - 4.3e-11 42.5 0.0 7.1e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 GRIP domain Filament PF00038.21 PIK41408.1 - 0.33 10.5 32.2 0.43 10.1 32.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein End3 PF12761.7 PIK41408.1 - 0.63 10.2 25.8 0.17 12.0 22.4 1.8 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 ApoLp-III PF07464.11 PIK41408.1 - 1.1 9.4 22.1 0.027 14.5 10.0 2.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Fib_alpha PF08702.10 PIK41408.1 - 1.9 8.7 24.2 0.15 12.2 17.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KH_10 PF17905.1 PIK41408.1 - 3.3 8.2 11.9 1.3 9.5 0.5 3.0 1 1 1 3 3 3 0 GLD-3 KH domain 5 Prominin PF05478.11 PIK41408.1 - 3.7 5.4 15.4 0.18 9.8 8.7 1.7 1 1 1 2 2 2 0 Prominin Adhesin_P1_N PF18652.1 PIK41408.1 - 5.6 7.1 12.2 1.1 9.4 1.0 2.9 2 1 1 3 3 3 0 Adhesin P1 N-terminal domain V_ATPase_I PF01496.19 PIK41408.1 - 6.2 4.6 23.4 7.9 4.3 23.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.11 PIK41408.1 - 7 6.1 16.6 0.45 10.0 7.2 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein Apolipoprotein PF01442.18 PIK41409.1 - 0.022 14.6 24.2 0.039 13.8 24.2 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HIP1_clath_bdg PF16515.5 PIK41409.1 - 0.043 14.4 8.0 0.043 14.4 8.0 3.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Filament PF00038.21 PIK41409.1 - 0.18 11.3 27.3 0.65 9.5 27.3 1.8 1 1 0 1 1 1 0 Intermediate filament protein DUF3080 PF11279.8 PIK41409.1 - 1.3 8.2 12.5 0.14 11.4 7.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3080) GAS PF13851.6 PIK41409.1 - 1.4 8.2 28.5 2.2 7.6 28.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2316 PF10078.9 PIK41409.1 - 2 8.7 8.8 0.6 10.4 1.6 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) Prominin PF05478.11 PIK41409.1 - 4.5 5.1 12.4 6.5 4.6 12.4 1.2 1 0 0 1 1 1 0 Prominin DUF1493 PF07377.12 PIK41409.1 - 5.3 7.5 8.0 3.7 8.0 2.3 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1493) Atg14 PF10186.9 PIK41409.1 - 7.7 5.5 22.5 1.3 8.0 12.3 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 PIK41409.1 - 9 5.1 32.6 5.8 5.7 17.6 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein LRR_8 PF13855.6 PIK41411.1 - 9.9e-64 211.0 67.5 6.1e-14 51.5 7.3 11.2 5 4 6 11 11 11 10 Leucine rich repeat LRR_5 PF13306.6 PIK41411.1 - 9.2e-36 122.6 18.7 9.4e-10 38.5 0.8 6.0 2 2 5 8 8 8 7 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK41411.1 - 2.7e-15 56.2 86.9 0.00023 21.5 2.1 12.7 7 2 7 16 16 16 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK41411.1 - 1.8e-07 30.9 22.8 0.00024 20.7 1.0 6.2 2 1 6 8 8 8 5 Leucine-rich repeat OAD_gamma PF04277.13 PIK41411.1 - 0.014 16.0 0.0 0.027 15.0 0.0 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain LRR_1 PF00560.33 PIK41411.1 - 6.4 7.7 61.1 6.8 7.7 0.2 14.7 16 2 0 16 16 16 0 Leucine Rich Repeat Sof1 PF04158.14 PIK41412.1 - 3.8e-29 100.8 12.5 6.1e-29 100.1 12.5 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 PIK41412.1 - 2.1e-21 75.8 6.5 0.00069 20.4 0.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 PIK41412.1 - 5.7e-07 29.6 0.1 8e-05 22.6 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK41412.1 - 0.076 12.0 0.0 0.18 10.8 0.0 1.6 2 0 0 2 2 2 0 Coatomer WD associated region 7tm_1 PF00001.21 PIK41413.1 - 4.6e-38 131.0 19.8 6.2e-38 130.6 19.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41413.1 - 2.7e-07 30.5 25.2 3.2e-07 30.3 24.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK41414.1 - 1.1e-34 120.0 20.9 1.5e-34 119.6 20.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41414.1 - 1.4e-09 38.0 25.0 1.7e-09 37.7 25.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK41414.1 - 2.5e-06 27.1 21.8 3.6e-06 26.6 21.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK41414.1 - 0.00027 20.4 16.9 0.00031 20.2 16.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Gaa1 PF04114.14 PIK41414.1 - 0.077 12.0 13.8 0.12 11.4 10.5 2.0 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component 7tm_1 PF00001.21 PIK41415.1 - 2e-38 132.3 27.4 2.6e-38 131.9 27.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41415.1 - 1e-10 41.7 28.6 1.3e-10 41.4 28.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK41415.1 - 2.7e-06 27.0 24.4 4.2e-06 26.3 24.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK41415.1 - 8.7e-06 25.3 19.0 1.2e-05 24.8 19.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DEAD PF00270.29 PIK41416.1 - 1.5e-38 132.3 0.0 3.9e-37 127.7 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK41416.1 - 1.2e-21 77.1 0.0 6.2e-21 74.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pkinase PF00069.25 PIK41417.1 - 3.6e-47 160.9 2.8 1.1e-46 159.3 0.1 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41417.1 - 2.8e-24 85.8 0.0 5.7e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBECR1 PF18809.1 PIK41417.1 - 2 9.1 7.0 2.2 9.0 0.1 3.3 3 0 0 3 3 3 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 HA2 PF04408.23 PIK41418.1 - 3e-23 82.1 0.1 3e-23 82.1 0.1 3.0 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK41418.1 - 9.2e-23 80.4 0.0 2e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 PIK41418.1 - 6.6e-15 55.2 0.4 1.9e-14 53.8 0.4 1.8 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 PIK41418.1 - 4.9e-13 49.4 0.0 1.2e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Apt1 PF10351.9 PIK41418.1 - 0.49 9.2 11.6 0.83 8.4 11.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 PIK41418.1 - 2.5 6.8 7.5 4 6.1 7.5 1.2 1 0 0 1 1 1 0 Presenilin Fasciclin PF02469.22 PIK41419.1 - 1.6e-59 199.7 0.9 2.2e-22 79.7 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain VWD PF00094.25 PIK41420.1 - 1.4e-13 51.4 0.0 2.5e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain Sushi PF00084.20 PIK41420.1 - 1.1e-06 29.1 0.8 2.6e-06 27.9 0.8 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) AMOP PF03782.17 PIK41420.1 - 0.0001 22.4 2.3 0.0004 20.5 2.3 2.0 1 1 0 1 1 1 1 AMOP domain NADH_u_ox_C PF12853.7 PIK41420.1 - 0.17 11.9 0.0 0.45 10.5 0.0 1.7 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Sod_Cu PF00080.20 PIK41421.1 - 7.4e-29 100.7 0.0 1.4e-28 99.9 0.0 1.4 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.26 PIK41421.1 - 1.7e-10 41.1 0.5 4.5e-10 39.8 0.1 1.9 2 0 0 2 2 2 1 Heavy-metal-associated domain Amb_V_allergen PF03913.13 PIK41421.1 - 0.58 10.1 5.3 1.8 8.6 0.5 2.7 2 0 0 2 2 2 0 Amb V Allergen Kazal_1 PF00050.21 PIK41422.1 - 1.1e-05 25.4 2.1 1.1e-05 25.4 2.1 1.4 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK41422.1 - 0.00011 22.2 5.6 0.00017 21.7 5.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Metallophos PF00149.28 PIK41423.1 - 8.3e-25 88.5 0.4 1.8e-24 87.4 0.4 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 PIK41423.1 - 9.5e-22 77.6 0.1 4.4e-21 75.5 0.1 2.2 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 PIK41423.1 - 2e-16 60.3 0.3 5.1e-16 59.0 0.3 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 PIK41423.1 - 0.078 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Methyltransf_25 PF13649.6 PIK41424.1 - 2e-13 50.9 0.0 3.2e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41424.1 - 5.3e-12 45.8 0.0 7.1e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK41424.1 - 1.3e-10 41.7 0.0 2.1e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK41424.1 - 1.5e-09 38.5 0.0 2.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK41424.1 - 4.9e-09 36.2 0.0 7.1e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK41424.1 - 6.7e-05 22.3 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 PIK41424.1 - 0.00035 20.2 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.11 PIK41424.1 - 0.0011 18.6 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 PIK41424.1 - 0.0014 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 PIK41424.1 - 0.0015 18.0 0.0 0.0032 16.9 0.0 1.5 2 0 0 2 2 2 1 Tellurite resistance protein TehB AdoMet_MTase PF07757.13 PIK41424.1 - 0.019 15.3 0.0 0.042 14.2 0.0 1.6 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 PIK41424.1 - 0.038 14.0 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 PIK41424.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Lectin_C PF00059.21 PIK41425.1 - 6.1e-22 78.4 0.1 9.1e-22 77.8 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK41425.1 - 0.0016 18.2 0.7 0.021 14.4 0.7 2.0 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Neur_chan_LBD PF02931.23 PIK41426.1 - 1.5e-14 53.9 0.1 1.8e-14 53.7 0.1 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CDC45 PF02724.14 PIK41427.1 - 0.0043 15.4 3.9 0.0043 15.4 3.9 1.1 1 0 0 1 1 1 1 CDC45-like protein PhoLip_ATPase_C PF16212.5 PIK41429.1 - 0.0027 17.5 0.9 0.0036 17.1 0.9 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal zf-RING_6 PF14835.6 PIK41429.1 - 0.092 12.6 1.1 0.16 11.8 1.1 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF2254 PF10011.9 PIK41429.1 - 0.35 9.7 4.3 0.088 11.6 0.8 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) MFS_3 PF05977.13 PIK41429.1 - 1.4 7.3 5.1 1.9 6.8 5.1 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector Afi1 PF07792.12 PIK41429.1 - 3.6 8.1 27.1 5.3 7.5 4.7 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RRM_1 PF00076.22 PIK41430.1 - 1.7e-31 107.9 0.0 4.8e-19 68.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK41430.1 - 0.00017 21.6 0.0 0.0026 17.8 0.0 2.8 3 1 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 PIK41430.1 - 0.0027 17.7 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 PIK41430.1 - 0.008 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif HCMVantigenic_N PF12154.8 PIK41430.1 - 5.2 7.3 6.6 16 5.7 0.3 2.4 2 0 0 2 2 2 0 Glycoprotein B N-terminal antigenic domain of HCMV RRM_1 PF00076.22 PIK41431.1 - 5.2e-33 112.7 0.0 3.1e-19 68.5 0.1 2.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK41431.1 - 0.00088 19.3 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 PIK41431.1 - 0.0015 18.6 0.0 0.41 10.7 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Caskin-Pro-rich PF16907.5 PIK41431.1 - 0.0018 18.8 3.7 0.0018 18.8 3.7 2.2 2 0 0 2 2 2 1 Proline rich region of Caskin proteins Nup35_RRM_2 PF14605.6 PIK41431.1 - 0.0047 16.9 0.0 0.013 15.4 0.0 1.7 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 PIK41431.1 - 0.006 16.4 0.0 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif Pyr_redox_dim PF02852.22 PIK41432.1 - 1.9e-34 118.2 0.2 4.1e-34 117.2 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 PIK41432.1 - 4.8e-30 104.8 0.1 3.6e-22 79.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK41432.1 - 5e-20 71.8 0.6 2.3e-19 69.7 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 PIK41432.1 - 0.00088 19.2 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 PIK41432.1 - 0.0015 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK41433.1 - 8.2e-16 58.1 0.0 9.2e-16 57.9 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 PIK41433.1 - 5.2e-05 22.8 0.0 5.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK41433.1 - 0.0002 20.6 0.1 0.00021 20.5 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 PIK41433.1 - 0.0041 16.4 0.2 0.0057 15.9 0.2 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 PIK41433.1 - 0.0041 16.4 0.0 0.0049 16.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK41433.1 - 0.0067 15.6 1.1 0.0092 15.1 1.1 1.1 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 PIK41433.1 - 0.024 13.9 0.4 0.033 13.5 0.3 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 PIK41433.1 - 0.026 14.7 0.4 0.04 14.2 0.4 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 PIK41433.1 - 0.099 11.3 0.5 0.17 10.6 0.5 1.3 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 PIK41433.1 - 0.2 11.2 1.7 0.19 11.3 1.7 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Sulfotransfer_1 PF00685.27 PIK41439.1 - 6.5e-06 25.8 0.0 8.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK41439.1 - 0.001 19.5 0.0 0.002 18.5 0.0 1.5 1 1 0 1 1 1 1 Sulfotransferase family Ig_3 PF13927.6 PIK41440.1 - 0.00046 20.7 0.6 2 9.0 0.3 3.4 2 1 0 2 2 2 2 Immunoglobulin domain TMEM154 PF15102.6 PIK41440.1 - 0.0015 18.5 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 PIK41440.1 - 0.0088 16.9 0.1 0.021 15.7 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ig_2 PF13895.6 PIK41440.1 - 0.011 16.1 0.9 13 6.2 0.4 3.3 2 1 0 2 2 2 0 Immunoglobulin domain Shisa PF13908.6 PIK41440.1 - 0.029 14.6 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Peptidase_M56 PF05569.11 PIK41440.1 - 0.065 12.4 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 Amnionless PF14828.6 PIK41440.1 - 0.13 11.1 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless RSN1_TM PF13967.6 PIK41440.1 - 1.7 8.4 5.1 0.37 10.5 0.2 2.2 3 0 0 3 3 3 0 Late exocytosis, associated with Golgi transport Integrase_H2C2 PF17921.1 PIK41441.1 - 7.5e-10 38.8 1.9 1.9e-09 37.5 1.9 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK41441.1 - 0.0034 17.6 1.6 0.0051 17.0 0.2 2.0 2 0 0 2 2 2 1 H2C2 zinc finger Peptidase_A17 PF05380.13 PIK41442.1 - 2.7e-58 196.5 0.0 3.8e-58 196.1 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK41442.1 - 0.0047 16.5 0.0 0.0078 15.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1759 PF03564.15 PIK41444.1 - 3.1e-05 24.0 0.1 0.00016 21.6 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) CLIP1_ZNF PF16641.5 PIK41444.1 - 0.074 13.0 3.2 0.17 11.8 3.2 1.6 1 0 0 1 1 1 0 CLIP1 zinc knuckle SET PF00856.28 PIK41445.1 - 1.2e-14 55.1 0.0 1.6e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 SET domain CPSase_L_D2 PF02786.17 PIK41446.1 - 3.3e-76 255.5 0.1 5.6e-76 254.7 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 PIK41446.1 - 9.3e-37 125.4 0.0 5.2e-36 123.0 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 PIK41446.1 - 7.8e-28 97.2 0.2 1.6e-24 86.5 0.0 2.7 2 0 0 2 2 2 2 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 PIK41446.1 - 1.1e-17 63.5 2.8 8.4e-17 60.8 1.8 2.6 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 PIK41446.1 - 1.5e-15 57.3 0.1 3.7e-15 56.0 0.1 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 PIK41446.1 - 4.8e-12 45.8 0.3 9.1e-12 44.9 0.3 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 PIK41446.1 - 4.7e-07 29.5 0.7 0.0012 18.7 0.0 3.1 2 1 1 3 3 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 PIK41446.1 - 7.6e-07 29.3 0.0 5.1e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 PIK41446.1 - 0.00039 20.1 0.0 0.004 16.8 0.0 2.2 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 PIK41446.1 - 0.00073 19.2 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 PIK41446.1 - 0.0016 17.7 0.1 0.044 13.0 0.0 2.5 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 PIK41446.1 - 0.0054 17.4 1.5 4.7 8.0 0.1 3.3 3 0 0 3 3 3 1 HlyD family secretion protein RnfC_N PF13375.6 PIK41446.1 - 0.0063 16.4 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ATPgrasp_ST PF14397.6 PIK41446.1 - 0.0092 15.3 0.0 2.6 7.2 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.6 PIK41446.1 - 0.024 14.4 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon GCV_H PF01597.19 PIK41446.1 - 0.074 13.0 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein PTS_EIIA_1 PF00358.20 PIK41446.1 - 0.093 12.5 0.0 0.59 9.9 0.0 2.3 1 1 1 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Ferric_reduct PF01794.19 PIK41447.1 - 0.026 14.7 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase like transmembrane component Mago_nashi PF02792.14 PIK41447.1 - 0.037 14.2 0.1 0.09 12.9 0.1 1.6 2 0 0 2 2 2 0 Mago nashi protein Ldl_recept_a PF00057.18 PIK41448.1 - 2e-96 315.9 180.5 7.5e-12 45.3 12.5 10.4 10 1 0 10 10 10 10 Low-density lipoprotein receptor domain class A fn3 PF00041.21 PIK41448.1 - 3.2e-15 56.2 0.4 1.4e-08 34.9 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain GPI-anchored PF10342.9 PIK41448.1 - 0.1 13.3 0.1 1 10.1 0.1 2.4 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Ldl_recept_b PF00058.17 PIK41449.1 - 5.6e-34 116.3 9.2 6.8e-11 42.5 0.3 4.9 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK41449.1 - 5.4e-07 29.4 1.1 0.0011 18.6 0.1 2.6 1 1 3 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region He_PIG PF05345.12 PIK41449.1 - 0.012 15.7 0.0 0.33 11.2 0.0 2.4 2 0 0 2 2 2 0 Putative Ig domain NHL PF01436.21 PIK41449.1 - 0.016 15.3 0.0 0.98 9.6 0.0 2.6 2 0 0 2 2 2 0 NHL repeat Arylesterase PF01731.20 PIK41449.1 - 0.043 14.0 0.0 2.8 8.2 0.0 2.8 2 1 1 3 3 3 0 Arylesterase DUF5050 PF16472.5 PIK41449.1 - 0.11 11.7 0.0 0.49 9.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5050) Dimer_Tnp_hAT PF05699.14 PIK41450.1 - 1.8e-19 69.3 0.0 3.7e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.15 PIK41450.1 - 1.9e-05 24.6 0.0 3.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF4413 PF14372.6 PIK41450.1 - 0.0022 18.4 0.3 0.0081 16.5 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) Sortilin-Vps10 PF15902.5 PIK41451.1 - 1.8e-79 267.6 0.0 2.4e-79 267.2 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 PIK41451.1 - 4.9e-12 46.5 0.0 7.8e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal LRR_8 PF13855.6 PIK41452.1 - 4.2e-33 112.9 15.0 5.4e-13 48.5 1.9 4.1 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK41452.1 - 6.6e-22 77.8 9.4 2.1e-10 40.6 0.4 2.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK41452.1 - 2.2e-13 50.2 19.9 9.1e-06 25.9 0.2 4.4 4 0 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK41452.1 - 2.9e-06 27.1 10.6 9.3 7.2 0.1 6.3 6 1 0 6 6 6 4 Leucine Rich Repeat LRR_9 PF14580.6 PIK41452.1 - 2.5e-05 23.9 4.1 0.0096 15.4 0.8 2.3 1 1 1 2 2 2 2 Leucine-rich repeat SLATT_5 PF18160.1 PIK41453.1 - 0.017 14.5 1.4 0.039 13.3 1.4 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 TNFR_c6 PF00020.18 PIK41453.1 - 0.073 13.5 1.0 0.073 13.5 1.0 2.8 2 1 1 3 3 3 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK41453.1 - 0.8 9.5 9.6 5.3 6.9 8.1 3.0 1 1 1 2 2 2 0 Putative ephrin-receptor like DED PF01335.21 PIK41454.1 - 0.014 15.7 0.1 0.03 14.6 0.1 1.5 1 0 0 1 1 1 0 Death effector domain Exo_endo_phos PF03372.23 PIK41455.1 - 0.00019 21.1 0.0 0.00048 19.7 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BRCT_3 PF18428.1 PIK41455.1 - 0.034 14.2 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain RVT_1 PF00078.27 PIK41457.1 - 1e-36 126.6 0.0 1.4e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-set PF07686.17 PIK41458.1 - 1.4e-05 25.2 0.0 2e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain rve PF00665.26 PIK41459.1 - 2.2e-21 76.2 0.0 4.9e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK41459.1 - 2.4e-20 72.8 0.2 6.7e-20 71.3 0.2 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK41459.1 - 2e-19 69.5 0.8 5.6e-19 68.0 0.8 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK41459.1 - 5.4e-10 39.2 0.1 1.5e-09 37.8 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK41459.1 - 0.014 15.1 0.0 0.042 13.6 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.10 PIK41459.1 - 0.026 14.7 0.1 0.063 13.5 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger DUF5332 PF17266.2 PIK41459.1 - 0.16 11.6 1.4 2.7 7.7 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5332) Fer4_4 PF12800.7 PIK41459.1 - 1.1 9.9 10.3 4.6 8.0 2.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain RT_RNaseH_2 PF17919.1 PIK41460.1 - 3.9e-15 55.7 0.0 6.6e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41460.1 - 2.7e-11 43.4 0.0 4.6e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK41460.1 - 0.0017 18.6 0.0 0.0036 17.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase AAA_25 PF13481.6 PIK41462.1 - 0.00061 19.4 0.0 0.0009 18.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK41462.1 - 0.0013 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain DAP3 PF10236.9 PIK41462.1 - 0.032 13.4 0.0 0.044 13.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 PIK41462.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 PIK41462.1 - 0.15 12.4 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase ER PF01133.17 PIK41463.1 - 0.04 14.0 0.3 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 Enhancer of rudimentary Hairy_orange PF07527.13 PIK41463.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Hairy Orange DUF2806 PF10987.8 PIK41465.1 - 0.061 13.2 0.1 0.098 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) RhoGAP PF00620.27 PIK41466.1 - 5.4e-40 136.7 0.1 1.9e-39 134.9 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain DUF2935 PF11155.8 PIK41466.1 - 0.52 10.6 3.2 33 4.8 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Spectrin PF00435.21 PIK41466.1 - 1.5 9.4 11.9 4.7 7.7 5.5 3.4 2 1 0 2 2 2 0 Spectrin repeat ING PF12998.7 PIK41466.1 - 6.5 7.4 8.8 1.2e+02 3.4 7.9 3.0 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding zf-CDGSH PF09360.10 PIK41467.1 - 1.8e-10 40.9 1.9 2.5e-10 40.4 1.9 1.4 1 1 0 1 1 1 1 Iron-binding zinc finger CDGSH type rve PF00665.26 PIK41469.1 - 4.7e-25 88.1 0.0 8.3e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK41469.1 - 2.7e-08 33.5 0.6 6e-08 32.3 0.2 1.8 2 0 0 2 2 2 1 Integrase core domain TNV_CP PF03898.13 PIK41470.1 - 0.22 10.8 0.0 0.28 10.4 0.0 1.1 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein zf-CCHC PF00098.23 PIK41471.1 - 0.00023 21.1 3.2 0.00023 21.1 3.2 2.8 3 0 0 3 3 3 1 Zinc knuckle TniQ PF06527.11 PIK41471.1 - 0.026 15.2 0.7 0.091 13.5 0.4 1.9 1 1 0 2 2 2 0 TniQ TackOD1 PF18551.1 PIK41471.1 - 0.068 12.8 8.6 0.15 11.7 8.5 1.7 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 DMAP1 PF05499.12 PIK41471.1 - 0.14 12.1 2.9 0.18 11.7 2.9 1.2 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) zf-CCHC_4 PF14392.6 PIK41471.1 - 6.8 6.5 7.8 10 6.0 6.1 2.1 2 0 0 2 2 2 0 Zinc knuckle Arf PF00025.21 PIK41472.1 - 4.9e-36 123.8 0.0 6.1e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 PIK41472.1 - 3.3e-14 52.8 0.0 3.7e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41472.1 - 1.5e-10 41.3 0.0 2.4e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK41472.1 - 4.8e-06 26.0 0.1 7.7e-06 25.3 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 PIK41472.1 - 1.3e-05 24.7 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK41472.1 - 0.024 14.7 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 PIK41472.1 - 0.12 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein 7tm_3 PF00003.22 PIK41473.1 - 2.2e-57 194.5 15.0 2.8e-57 194.2 15.0 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK41473.1 - 6.1e-10 38.9 8.3 1.2e-09 38.0 8.3 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF1218 PF06749.12 PIK41473.1 - 0.015 15.8 6.4 7 7.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) DUF3810 PF12725.7 PIK41473.1 - 0.23 10.8 5.1 5.5 6.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) CDP-OH_P_transf PF01066.21 PIK41473.1 - 0.43 11.4 4.2 4.3 8.2 4.2 2.6 1 1 0 1 1 1 0 CDP-alcohol phosphatidyltransferase Phage_holin_5_2 PF16079.5 PIK41473.1 - 3.2 8.2 8.5 1.1 9.7 0.8 2.9 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V Claudin_2 PF13903.6 PIK41473.1 - 5.7 6.7 11.2 0.042 13.6 1.0 2.3 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction 7tm_1 PF00001.21 PIK41474.1 - 3.9e-19 69.0 9.6 5.8e-19 68.4 9.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK41474.1 - 0.0085 15.4 4.8 0.012 14.9 4.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Lipoprotein_21 PF14041.6 PIK41474.1 - 0.039 14.1 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 LppP/LprE lipoprotein GWT1 PF06423.12 PIK41474.1 - 0.1 12.7 4.3 0.056 13.6 1.7 1.7 1 1 1 2 2 2 0 GWT1 Ank_2 PF12796.7 PIK41475.1 - 4.6e-55 184.1 10.5 2.9e-15 56.6 0.1 5.0 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK41475.1 - 1.9e-39 133.5 11.3 1e-09 38.7 0.0 7.1 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 PIK41475.1 - 6.6e-39 130.7 12.7 1.4e-06 28.5 0.2 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 PIK41475.1 - 4.1e-37 122.0 6.1 1.1e-05 25.5 0.1 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 PIK41475.1 - 2e-33 114.0 11.9 3.9e-08 33.4 0.1 6.8 2 2 5 7 7 7 7 Ankyrin repeats (many copies) SAM_1 PF00536.30 PIK41475.1 - 1.1e-11 44.9 0.2 2.8e-11 43.7 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK41475.1 - 1.5e-09 37.8 0.1 3.2e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) F-box-like PF12937.7 PIK41476.1 - 3.6e-12 46.0 0.5 6.4e-12 45.2 0.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK41476.1 - 8.2e-09 35.1 0.1 2.3e-08 33.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain TPP1 PF10341.9 PIK41477.1 - 1.7e-06 27.9 0.0 5.2e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD AA_permease_2 PF13520.6 PIK41478.1 - 9.4e-58 196.0 38.1 1.2e-57 195.7 38.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK41478.1 - 2.8e-21 75.7 37.4 4.2e-21 75.1 37.4 1.2 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 PIK41479.1 - 5.3e-17 61.8 17.9 6.3e-17 61.5 17.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK41479.1 - 3.9e-07 29.0 13.8 4.5e-07 28.8 13.8 1.1 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 PIK41479.1 - 0.029 13.4 10.6 0.035 13.2 10.6 1.0 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family zf-C2H2 PF00096.26 PIK41480.1 - 0.28 11.7 1.0 0.61 10.7 1.0 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type RVT_1 PF00078.27 PIK41481.1 - 1.4e-23 83.6 0.1 2.1e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CotJB PF12652.7 PIK41481.1 - 0.055 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 CotJB protein AA_permease_2 PF13520.6 PIK41482.1 - 6.3e-55 186.7 41.5 8e-55 186.4 41.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK41482.1 - 4.7e-18 65.0 40.6 1.2e-17 63.7 40.6 1.6 1 1 0 1 1 1 1 Amino acid permease MFS_Mycoplasma PF07672.13 PIK41482.1 - 3.6 6.8 13.6 14 4.9 12.2 2.5 1 1 0 1 1 1 0 Mycoplasma MFS transporter adh_short PF00106.25 PIK41483.1 - 8.5e-27 93.9 0.0 5e-25 88.1 0.0 2.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK41483.1 - 3e-15 56.4 0.0 2.7e-13 50.0 0.0 2.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK41483.1 - 1.7e-05 24.8 0.0 3.9e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 KR domain DUF1160 PF06648.11 PIK41483.1 - 0.12 12.4 0.1 0.36 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) RRM_1 PF00076.22 PIK41484.1 - 2.3e-40 136.3 9.3 8.7e-17 60.7 0.1 6.0 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK41484.1 - 0.0066 16.5 0.0 0.73 10.0 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif Mak_N_cap PF18085.1 PIK41484.1 - 0.11 13.6 0.2 0.27 12.3 0.2 1.7 1 0 0 1 1 1 0 Maltokinase N-terminal cap domain Methyltransf_25 PF13649.6 PIK41485.1 - 5.8e-12 46.2 0.0 7.9e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK41485.1 - 9.2e-12 45.5 0.0 1.3e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41485.1 - 4.7e-09 36.2 0.1 5.8e-09 35.9 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK41485.1 - 6e-07 30.1 0.0 8.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK41485.1 - 6.1e-06 26.2 0.0 7e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK41485.1 - 0.00017 21.2 0.0 0.00023 20.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 PIK41485.1 - 0.0004 20.0 0.0 0.0005 19.7 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Polbeta PF18765.1 PIK41485.1 - 0.00051 20.1 0.0 0.00069 19.6 0.0 1.2 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Methyltransf_32 PF13679.6 PIK41485.1 - 0.00053 20.0 0.0 0.00061 19.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK41485.1 - 0.002 17.5 0.0 0.0023 17.3 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK41485.1 - 0.0035 17.1 0.0 0.0035 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) tRNA_U5-meth_tr PF05958.11 PIK41485.1 - 0.0039 16.2 0.0 0.0039 16.2 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_4 PF02390.17 PIK41485.1 - 0.011 15.2 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 PIK41485.1 - 0.015 14.7 0.1 0.019 14.4 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 PIK41485.1 - 0.023 14.3 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 PIK41485.1 - 0.023 14.0 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AdoMet_MTase PF07757.13 PIK41485.1 - 0.045 14.1 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TehB PF03848.14 PIK41485.1 - 0.074 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 PIK41485.1 - 0.091 12.7 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 PIK41485.1 - 0.096 11.6 0.0 0.099 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DREV PF05219.12 PIK41485.1 - 0.13 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_15 PF09445.10 PIK41485.1 - 0.2 11.2 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UDPGT PF00201.18 PIK41486.1 - 6.8e-44 150.5 0.1 8.1e-44 150.2 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK41486.1 - 0.0067 16.4 0.0 0.0091 16.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_29 PF00777.18 PIK41487.1 - 2.1e-36 125.7 0.1 2.7e-36 125.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ank_2 PF12796.7 PIK41489.1 - 4.1e-47 158.7 1.1 3.9e-14 53.0 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK41489.1 - 2.3e-27 95.0 2.7 5.9e-10 39.5 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK41489.1 - 3.5e-27 93.6 0.3 0.00015 22.1 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 PIK41489.1 - 6.5e-27 93.3 4.5 2.9e-07 30.6 0.1 5.2 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK41489.1 - 1.2e-24 83.7 0.9 0.00089 19.5 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Pre-SET PF05033.16 PIK41489.1 - 6.1e-09 36.5 5.4 6.2e-09 36.5 2.8 2.1 2 0 0 2 2 2 1 Pre-SET motif preSET_CXC PF18264.1 PIK41489.1 - 0.2 12.2 11.2 0.81 10.2 11.2 2.1 1 0 0 1 1 1 0 CXC domain CSRNP_N PF16019.5 PIK41489.1 - 0.67 9.8 7.2 1.4 8.8 7.2 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Laminin_EGF PF00053.24 PIK41491.1 - 4.1e-48 161.3 139.2 5.8e-11 42.4 14.7 8.7 9 0 0 9 9 9 7 Laminin EGF domain Laminin_N PF00055.17 PIK41491.1 - 1e-45 156.2 0.0 1e-45 156.2 0.0 2.6 4 0 0 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK41491.1 - 1.5e-23 83.2 0.0 2.6e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Laminin B (Domain IV) Big_3_2 PF12245.8 PIK41491.1 - 0.024 14.9 0.4 0.042 14.1 0.4 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain Laminin_EGF PF00053.24 PIK41492.1 - 7.6e-09 35.6 15.3 1.9e-08 34.3 15.4 1.6 1 1 0 1 1 1 1 Laminin EGF domain DUF842 PF05811.13 PIK41492.1 - 0.00052 19.7 3.7 0.00052 19.7 3.7 2.2 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF842) ERM PF00769.19 PIK41492.1 - 0.075 12.8 19.3 0.058 13.2 13.0 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Halogen_Hydrol PF10112.9 PIK41492.1 - 0.23 11.4 10.0 0.13 12.2 2.3 2.2 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Allexi_40kDa PF05549.11 PIK41492.1 - 1.5 8.3 6.5 4.7 6.6 0.2 2.4 1 1 2 3 3 3 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.6 PIK41492.1 - 3.4 8.1 12.5 0.51 10.8 2.8 3.4 1 1 1 3 3 3 0 Snapin/Pallidin DUF745 PF05335.13 PIK41492.1 - 4.2 7.0 16.0 22 4.7 14.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) T3SSipB PF16535.5 PIK41492.1 - 5 7.6 14.1 2.4 8.6 8.7 2.6 1 1 1 2 2 2 0 Type III cell invasion protein SipB Csm1_N PF18504.1 PIK41492.1 - 9.8 6.6 14.5 2.8 8.4 1.4 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain FtsX_ECD PF18075.1 PIK41493.1 - 0.29 11.8 0.1 0.29 11.8 0.1 4.1 1 1 3 5 5 5 0 FtsX extracellular domain Syntaxin-6_N PF09177.11 PIK41493.1 - 2.1 9.0 11.8 1.1 9.9 1.3 3.3 2 2 0 2 2 2 0 Syntaxin 6, N-terminal FlaC_arch PF05377.11 PIK41493.1 - 5.7 7.4 13.8 12 6.4 0.8 4.2 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Clr2 PF10383.9 PIK41493.1 - 8.3 7.2 6.1 30 5.4 6.0 2.1 1 1 0 1 1 1 0 Transcription-silencing protein Clr2 rve PF00665.26 PIK41494.1 - 3.7e-25 88.4 0.0 9.6e-25 87.1 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41494.1 - 1.8e-19 69.5 5.2 2e-19 69.4 2.7 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK41494.1 - 0.00031 20.5 0.0 0.00084 19.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK41495.1 - 5.7e-35 119.4 0.0 1.1e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK41495.1 - 9e-35 119.1 0.1 1.6e-34 118.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41495.1 - 2.7e-29 102.3 0.0 4.2e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK41495.1 - 0.0011 19.2 0.0 0.73 10.0 0.0 2.4 1 1 1 2 2 2 2 Spumavirus aspartic protease (A9) Retrotrans_gag PF03732.17 PIK41496.1 - 4.5e-05 23.6 0.2 0.00025 21.3 0.1 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF1759 PF03564.15 PIK41496.1 - 0.0059 16.5 0.0 0.0091 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Ribosomal_S2 PF00318.20 PIK41497.1 - 2e-14 53.4 0.0 2.3e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S2 CHAT PF12770.7 PIK41498.1 - 2.1e-20 73.3 0.1 4.2e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 CHAT domain Caskin-Pro-rich PF16907.5 PIK41498.1 - 0.26 11.8 6.0 0.92 10.1 6.0 1.9 1 0 0 1 1 1 0 Proline rich region of Caskin proteins TPR_2 PF07719.17 PIK41499.1 - 6.7e-23 78.9 6.7 0.0007 19.5 0.0 7.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41499.1 - 1.9e-21 74.9 12.7 0.00011 21.9 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41499.1 - 3.7e-19 67.3 8.2 0.00049 20.1 0.3 7.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 PIK41499.1 - 8.4e-12 45.2 10.0 0.22 11.8 0.0 5.8 4 3 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK41499.1 - 4e-11 42.7 1.3 2 9.4 0.1 7.5 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK41499.1 - 7.3e-09 35.7 6.0 0.22 12.2 0.0 6.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK41499.1 - 1.9e-08 34.8 2.8 0.19 12.4 0.0 4.7 3 2 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK41499.1 - 3.7e-07 30.3 7.9 0.00042 20.5 0.1 4.3 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK41499.1 - 6.2e-06 25.8 4.2 0.97 9.2 0.0 5.2 5 0 0 5 5 5 2 TPR repeat TPR_9 PF13371.6 PIK41499.1 - 0.00028 21.0 3.8 1.1 9.5 0.0 4.6 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41499.1 - 0.00035 20.4 10.5 2 8.6 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat MIT PF04212.18 PIK41499.1 - 0.0011 19.0 3.2 54 4.0 0.0 5.5 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 PIK41499.1 - 0.0014 18.8 2.4 20 5.8 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK41499.1 - 0.0032 17.5 1.0 1.7 8.8 0.0 4.0 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 PIK41499.1 - 0.0053 17.2 7.3 0.22 12.1 0.2 4.5 5 1 1 6 6 6 1 Tetratricopeptide repeat DUF3507 PF12015.8 PIK41499.1 - 0.012 15.3 0.1 0.012 15.3 0.1 1.8 2 1 0 2 2 1 0 Domain of unknown function (DUF3507) RPN7 PF10602.9 PIK41499.1 - 0.016 14.9 1.8 0.055 13.2 0.1 2.4 2 1 0 2 2 2 0 26S proteasome subunit RPN7 PHA_synth_III_E PF09712.10 PIK41499.1 - 0.025 13.7 0.1 0.048 12.7 0.1 1.4 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF2312 PF10073.9 PIK41499.1 - 0.087 12.5 1.0 11 5.8 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF4363 PF14276.6 PIK41499.1 - 2 8.6 6.0 6.3 7.0 3.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4363) MIF PF01187.18 PIK41500.1 - 5.6e-07 29.8 0.0 1.2e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) SpoIIIAH PF12685.7 PIK41501.1 - 0.00024 21.0 0.7 0.00042 20.2 0.7 1.4 1 0 0 1 1 1 1 SpoIIIAH-like protein Collectrin PF16959.5 PIK41501.1 - 0.0044 16.8 0.0 0.0067 16.2 0.0 1.2 1 0 0 1 1 1 1 Renal amino acid transporter Smim3 PF17307.2 PIK41501.1 - 0.033 13.7 0.3 0.051 13.1 0.3 1.3 1 0 0 1 1 1 0 Small integral membrane protein 3 DUF4834 PF16118.5 PIK41501.1 - 0.076 14.0 0.8 0.24 12.4 0.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Alg14 PF08660.11 PIK41502.1 - 1.1e-46 158.9 0.3 1.3e-46 158.8 0.3 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like TRAM_LAG1_CLN8 PF03798.16 PIK41503.1 - 4e-32 111.6 10.6 4e-32 111.6 10.6 1.4 2 0 0 2 2 2 1 TLC domain DUF1232 PF06803.12 PIK41504.1 - 1.6e-11 43.8 9.8 4e-11 42.5 9.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1232) zf-C3HC4_3 PF13920.6 PIK41504.1 - 3.4e-08 33.2 3.8 5.5e-08 32.5 3.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK41504.1 - 1.3e-07 31.4 5.3 2.7e-07 30.3 5.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK41504.1 - 1.6e-07 31.3 4.8 4.2e-07 29.9 2.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK41504.1 - 2.7e-07 30.8 6.4 4.3e-07 30.1 6.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK41504.1 - 4e-07 29.8 4.4 6.6e-07 29.1 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK41504.1 - 3.9e-05 23.7 5.4 7.3e-05 22.9 5.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK41504.1 - 4.8e-05 23.1 5.3 0.00055 19.7 5.9 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK41504.1 - 0.00017 21.5 5.8 0.00055 19.8 5.9 1.8 1 1 0 1 1 1 1 zinc-RING finger domain tRNA-synt_1g PF09334.11 PIK41504.1 - 0.003 16.4 0.3 0.0043 15.9 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) zf-ANAPC11 PF12861.7 PIK41504.1 - 0.017 15.2 3.1 0.037 14.1 3.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 PIK41504.1 - 0.096 13.0 3.9 0.21 11.9 3.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 PIK41504.1 - 0.12 12.4 3.0 0.29 11.1 3.0 1.6 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Elf1 PF05129.13 PIK41504.1 - 1.8 8.7 4.0 51 4.0 4.0 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-WRNIP1_ubi PF18279.1 PIK41504.1 - 3.2 8.6 5.7 22 6.0 1.1 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_4 PF14570.6 PIK41504.1 - 3.3 7.6 7.6 41 4.1 8.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 PIK41504.1 - 4.4 7.4 6.2 17 5.5 6.2 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain Neuralized PF07177.12 PIK41505.1 - 1.8e-27 96.2 0.0 5e-27 94.7 0.0 1.8 1 0 0 1 1 1 1 Neuralized COR PF16095.5 PIK41505.1 - 8.3e-09 35.5 0.1 2.2e-08 34.2 0.1 1.7 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Death PF00531.22 PIK41505.1 - 2.5e-06 27.6 0.6 7.6e-06 26.0 0.1 2.1 2 0 0 2 2 2 1 Death domain PolC_DP2 PF03833.13 PIK41505.1 - 0.045 11.6 0.4 0.076 10.9 0.4 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 BSMAP PF12280.8 PIK41506.1 - 4.3e-52 177.1 0.1 4.3e-52 177.1 0.1 1.3 2 0 0 2 2 2 1 Brain specific membrane anchored protein Glyco_transf_29 PF00777.18 PIK41507.1 - 3.1e-39 135.0 0.4 4.4e-39 134.5 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RVT_1 PF00078.27 PIK41508.1 - 5.6e-18 65.3 0.0 6.7e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HD PF01966.22 PIK41509.1 - 0.012 15.8 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 HD domain TTSSLRR PF12468.8 PIK41510.1 - 1.9e-05 24.8 1.6 30 5.0 0.0 5.1 5 0 0 5 5 5 1 Type III secretion system leucine rich repeat protein DUF1670 PF07900.11 PIK41510.1 - 0.051 12.9 0.1 69 2.7 0.0 4.0 2 1 1 5 5 5 0 Protein of unknown function (DUF1670) LIX1 PF14954.6 PIK41510.1 - 0.27 10.5 7.9 23 4.2 0.1 4.7 2 2 4 6 6 6 0 Limb expression 1 DUF4175 PF13779.6 PIK41510.1 - 0.69 7.7 7.3 1.4 6.7 0.3 2.6 1 1 4 5 5 5 0 Domain of unknown function (DUF4175) CM2 PF03021.14 PIK41510.1 - 3.1 7.6 9.9 70 3.2 0.1 4.6 1 1 4 5 5 5 0 Influenza C virus M2 protein SSF PF00474.17 PIK41511.1 - 5.6e-50 170.4 24.2 8.5e-50 169.8 24.2 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SafA PF17073.5 PIK41511.1 - 0.52 10.3 3.5 2 8.4 0.8 3.0 2 1 1 3 3 3 0 Two-component-system connector protein adh_short PF00106.25 PIK41512.1 - 1e-31 110.0 0.3 2.3e-31 108.8 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK41512.1 - 9.4e-29 100.6 0.2 2e-28 99.6 0.1 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 PIK41512.1 - 1.4e-22 80.1 1.0 3.8e-22 78.7 1.0 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 PIK41512.1 - 4.1e-06 27.1 0.1 3.7e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 Alkyl sulfatase C-terminal KR PF08659.10 PIK41512.1 - 2.1e-05 24.5 0.1 4.3e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 PIK41512.1 - 0.033 13.6 0.1 0.064 12.6 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SCP2_2 PF13530.6 PIK41512.1 - 0.042 14.3 0.0 0.085 13.3 0.0 1.4 1 0 0 1 1 1 0 Sterol carrier protein domain RVT_1 PF00078.27 PIK41513.1 - 2.5e-06 27.2 0.1 4.7e-06 26.3 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK41514.1 - 1.1e-17 63.8 0.4 2.2e-17 62.9 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK41514.1 - 1.7e-17 63.7 0.0 4e-17 62.5 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK41514.1 - 1.1e-05 25.6 0.1 2e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Myosin_N PF02736.19 PIK41514.1 - 0.0035 17.1 0.1 0.0068 16.2 0.1 1.3 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain rve_3 PF13683.6 PIK41514.1 - 0.0059 16.4 0.1 0.023 14.4 0.1 2.1 2 0 0 2 2 2 1 Integrase core domain TUDOR PF00567.24 PIK41514.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Tudor domain Agenet PF05641.12 PIK41514.1 - 0.069 13.6 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 Agenet domain RVT_1 PF00078.27 PIK41515.1 - 2.2e-34 118.9 0.1 2.8e-34 118.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Y_phosphatase PF00102.27 PIK41516.1 - 4e-84 281.8 0.2 4.6e-48 163.8 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK41516.1 - 5.6e-06 26.2 0.3 4e-05 23.4 0.0 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK41516.1 - 0.00076 19.5 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK41516.1 - 0.0014 18.7 0.0 0.0052 16.9 0.0 2.0 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK41516.1 - 0.0074 15.9 0.1 0.014 15.0 0.1 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Bac_DnaA PF00308.18 PIK41516.1 - 0.093 12.5 0.0 1.6 8.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein Fibrinogen_C PF00147.18 PIK41517.1 - 1.4e-19 70.7 0.7 1.7e-19 70.5 0.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK41518.1 - 2.8e-29 102.5 2.1 3.2e-29 102.3 2.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK41519.1 - 7.1e-52 176.4 5.1 8.7e-52 176.1 5.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK41520.1 - 1.1e-09 38.5 0.0 1.2e-09 38.4 0.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain NACHT PF05729.12 PIK41522.1 - 5.5e-09 36.2 0.1 1.5e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain V-set PF07686.17 PIK41522.1 - 3.4e-06 27.2 0.0 0.0081 16.3 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41522.1 - 0.00021 21.8 0.2 20 5.9 0.0 5.3 5 1 0 5 5 5 0 Immunoglobulin domain IstB_IS21 PF01695.17 PIK41522.1 - 0.00022 21.0 0.0 0.00063 19.5 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein C2-set_2 PF08205.12 PIK41522.1 - 0.00068 19.7 0.2 0.71 10.0 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK41522.1 - 0.0043 17.1 0.0 15 5.8 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain AAA_22 PF13401.6 PIK41522.1 - 0.027 14.8 0.2 0.24 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ig_2 PF13895.6 PIK41522.1 - 0.028 14.8 0.2 5.1 7.5 0.0 3.8 4 0 0 4 4 4 0 Immunoglobulin domain ResIII PF04851.15 PIK41522.1 - 0.058 13.4 4.7 0.55 10.2 0.0 3.1 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 PIK41522.1 - 0.63 10.1 3.2 0.36 10.9 0.2 2.2 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.17 PIK41523.1 - 1.5e-14 53.9 0.1 2.9e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41523.1 - 1.5e-08 34.4 0.1 2.5e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK41523.1 - 0.0059 16.7 0.1 0.068 13.2 0.0 2.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain RVT_1 PF00078.27 PIK41524.1 - 5.6e-16 58.7 0.0 8.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK41524.1 - 0.0042 16.7 0.1 0.0069 16.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) RVT_1 PF00078.27 PIK41525.1 - 1.6e-36 125.9 0.0 2.1e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK41525.1 - 4.1e-07 29.5 0.1 1.3e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) Fibrinogen_C PF00147.18 PIK41526.1 - 3e-28 99.1 1.0 3.9e-28 98.8 1.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Mon1 PF03164.14 PIK41527.1 - 9e-148 492.6 0.2 1e-147 492.5 0.2 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 YrbL-PhoP_reg PF10707.9 PIK41528.1 - 0.068 12.7 2.2 0.097 12.2 1.4 1.6 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL Pacs-1 PF10254.9 PIK41528.1 - 0.61 9.0 9.3 0.93 8.4 9.3 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein MOLO1 PF17175.4 PIK41529.1 - 0.071 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Modulator of levamisole receptor-1 TMEM154 PF15102.6 PIK41529.1 - 0.078 12.9 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family ORMDL PF04061.14 PIK41529.1 - 0.1 12.4 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 ORMDL family NUC194 PF08163.12 PIK41530.1 - 6.3e-140 466.5 1.0 1.3e-139 465.4 0.2 2.1 2 0 0 2 2 2 1 NUC194 domain PI3_PI4_kinase PF00454.27 PIK41530.1 - 2.4e-55 188.1 0.2 5.8e-55 186.8 0.2 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 PIK41530.1 - 7.6e-21 74.7 12.2 5e-19 68.7 5.6 3.2 1 1 1 3 3 3 2 FAT domain FATC PF02260.20 PIK41530.1 - 6.9e-15 54.6 0.0 6.9e-15 54.6 0.0 2.2 2 0 0 2 2 2 1 FATC domain MIT PF04212.18 PIK41530.1 - 0.0079 16.2 3.5 0.014 15.5 1.1 2.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 PIK41530.1 - 0.022 15.2 0.5 8.9 6.9 0.3 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41530.1 - 0.067 13.2 0.6 5.7 7.2 0.3 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41530.1 - 0.07 13.4 0.7 18 5.9 0.4 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Alpha-mann_mid PF09261.11 PIK41530.1 - 0.14 12.3 1.6 0.55 10.4 0.2 2.9 2 0 0 2 2 1 0 Alpha mannosidase middle domain TPR_11 PF13414.6 PIK41530.1 - 0.15 11.7 0.5 0.42 10.3 0.5 1.7 1 0 0 1 1 1 0 TPR repeat TPR_1 PF00515.28 PIK41530.1 - 0.25 11.2 1.3 5.1 7.1 1.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK41530.1 - 0.72 10.1 4.8 1.7 8.9 1.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Snurportin1 PF11538.8 PIK41530.1 - 1.2 9.4 4.6 4 7.7 4.6 2.0 1 0 0 1 1 1 0 Snurportin1 HEAT PF02985.22 PIK41531.1 - 0.042 14.1 0.6 15 6.2 0.1 4.5 5 0 0 5 5 5 0 HEAT repeat PI3K_P85_iSH2 PF16454.5 PIK41531.1 - 0.054 13.1 1.0 0.19 11.3 1.0 1.9 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain pEK499_p136 PF18736.1 PIK41531.1 - 0.098 12.3 0.3 0.9 9.1 0.1 2.6 2 0 0 2 2 2 0 HEPN pEK499 p136 RIX1 PF08167.12 PIK41531.1 - 0.19 11.5 4.1 0.22 11.3 0.3 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Sulfate_transp PF00916.20 PIK41532.1 - 3.9e-88 295.8 19.3 5.8e-46 157.0 8.7 2.1 2 0 0 2 2 2 2 Sulfate permease family STAS PF01740.21 PIK41532.1 - 1.2e-10 41.1 0.3 2.4e-10 40.1 0.3 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 PIK41532.1 - 0.0011 19.3 4.6 0.0011 19.3 4.6 3.3 2 1 0 2 2 2 1 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 PIK41533.1 - 1.5e-73 247.8 24.5 2e-73 247.4 24.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 PIK41533.1 - 5.2e-08 32.5 0.0 1.3e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 STAS domain DUF4351 PF14261.6 PIK41533.1 - 0.02 15.0 0.0 0.06 13.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4351) MFS_MOT1 PF16983.5 PIK41533.1 - 1.2 9.5 12.4 0.041 14.3 2.7 3.2 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily Actin PF00022.19 PIK41534.1 - 3.1e-89 299.4 0.0 1.3e-88 297.3 0.0 1.7 1 1 0 1 1 1 1 Actin Actin PF00022.19 PIK41535.1 - 4.1e-71 239.7 0.0 4.6e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Actin GerD PF17898.1 PIK41535.1 - 0.17 11.9 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Spore germination GerD central core domain DM PF00751.18 PIK41536.1 - 4.4e-14 52.1 13.5 4.4e-14 52.1 13.5 2.4 2 0 0 2 2 2 1 DM DNA binding domain Eapp_C PF10238.9 PIK41537.1 - 0.57 10.3 7.5 0.14 12.2 3.8 1.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein GrpE PF01025.19 PIK41537.1 - 0.57 9.8 13.9 0.12 12.0 10.3 1.8 1 1 1 2 2 2 0 GrpE DUF2262 PF10020.9 PIK41537.1 - 0.59 10.5 5.4 1 9.7 5.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) Egg_lysin PF01303.17 PIK41537.1 - 0.7 10.1 6.8 0.16 12.2 1.7 2.3 2 0 0 2 2 2 0 Egg lysin (Sperm-lysin) LicD PF04991.13 PIK41537.1 - 3.9 7.6 7.5 0.89 9.7 4.3 1.5 2 0 0 2 2 2 0 LicD family TMEM119 PF15724.5 PIK41537.1 - 5.1 7.1 8.0 5.2 7.1 0.3 2.2 2 0 0 2 2 2 0 TMEM119 family Ank_2 PF12796.7 PIK41538.1 - 8.3e-19 68.0 0.7 2.5e-10 40.8 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK41538.1 - 4.3e-18 65.4 0.5 3.9e-05 24.1 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK41538.1 - 5.1e-15 55.1 1.1 0.0094 16.4 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 PIK41538.1 - 2e-13 49.2 1.4 0.24 12.1 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK41538.1 - 1.1e-09 38.3 2.2 8.1e-05 22.8 0.8 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) NPR3 PF03666.13 PIK41539.1 - 5.1e-43 147.5 1.5 2.6e-31 109.0 0.4 2.4 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 PIK41539.1 - 1.1e-06 27.7 0.0 8.4e-06 24.8 0.0 2.1 1 1 0 1 1 1 1 Nitrogen permease regulator 2 MIF PF01187.18 PIK41540.1 - 0.15 12.4 0.0 0.22 11.8 0.0 1.3 1 1 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) Molydop_binding PF01568.21 PIK41540.1 - 0.17 12.0 0.0 0.35 10.9 0.0 1.5 2 0 0 2 2 2 0 Molydopterin dinucleotide binding domain Tautomerase PF01361.21 PIK41540.1 - 0.21 11.6 0.0 0.74 9.8 0.0 1.9 2 1 0 2 2 2 0 Tautomerase enzyme ZU5 PF00791.20 PIK41542.1 - 3e-15 56.4 0.0 6.8e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK41542.1 - 2.2e-10 40.6 1.6 4.8e-10 39.5 1.6 1.6 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK41543.1 - 4.2e-10 39.8 0.0 1.3e-09 38.3 0.0 1.8 1 0 0 1 1 1 1 ZU5 domain zf-RING_UBOX PF13445.6 PIK41545.1 - 3.5e-09 36.5 6.7 1.2e-08 34.8 6.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK41545.1 - 2.4e-08 33.7 7.1 2.4e-08 33.7 7.1 3.4 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK41545.1 - 1e-06 28.8 9.2 1e-06 28.8 9.2 3.4 3 1 1 4 4 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK41545.1 - 1.3e-05 24.9 9.5 1.3e-05 24.9 9.5 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK41545.1 - 3.9e-05 23.7 13.8 3.9e-05 23.7 13.8 3.4 3 0 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.6 PIK41545.1 - 5.3e-05 23.5 7.4 5.3e-05 23.5 7.4 3.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK41545.1 - 6.6e-05 22.7 8.1 6.6e-05 22.7 8.1 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK41545.1 - 0.0016 18.3 6.7 0.0016 18.3 6.7 3.3 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 PIK41545.1 - 0.37 10.6 10.1 0.046 13.5 4.4 2.6 2 0 0 2 2 2 0 RING-like zinc finger Vip3A_N PF12495.8 PIK41545.1 - 0.7 9.8 7.9 0.44 10.4 5.6 1.9 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal DUF3584 PF12128.8 PIK41545.1 - 0.71 7.3 27.0 0.046 11.2 12.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4633 PF15464.6 PIK41545.1 - 0.82 9.8 8.1 0.46 10.6 1.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) DUF4407 PF14362.6 PIK41545.1 - 1.2 8.4 21.1 0.28 10.5 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TetR_C_24 PF17932.1 PIK41545.1 - 5.4 7.3 5.6 1.6 9.0 0.4 2.6 2 2 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LAMTOR PF15454.6 PIK41545.1 - 5.8 7.6 12.4 0.59 10.8 1.7 3.6 2 1 1 3 3 3 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator EHN PF06441.12 PIK41545.1 - 5.9 7.3 10.8 15 6.0 3.8 2.6 2 0 0 2 2 2 0 Epoxide hydrolase N terminus zf-H2C2_2 PF13465.6 PIK41547.1 - 2.1e-33 113.2 83.5 3.4e-06 27.2 5.2 9.4 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK41547.1 - 1.7e-14 53.4 82.7 0.0014 19.0 1.7 8.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK41547.1 - 8.1e-14 51.2 74.8 0.01 16.6 3.3 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK41547.1 - 1.9e-07 31.2 57.7 0.037 14.3 5.7 8.2 6 2 2 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK41547.1 - 0.0006 20.1 3.8 0.0006 20.1 3.8 7.4 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK41547.1 - 0.014 15.2 0.6 0.014 15.2 0.6 5.1 6 0 0 6 6 6 0 zinc-finger C2H2-type Ras PF00071.22 PIK41548.1 - 5.4e-17 61.9 0.1 7.6e-17 61.4 0.1 1.2 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 PIK41548.1 - 0.00098 18.7 0.1 0.0012 18.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK41548.1 - 0.001 18.6 0.3 0.0021 17.6 0.1 1.5 1 1 1 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK41548.1 - 0.032 14.1 0.0 0.049 13.5 0.0 1.3 1 1 0 1 1 1 0 RsgA GTPase TED_complement PF07678.14 PIK41550.1 - 2.9e-88 295.9 0.0 4.8e-88 295.2 0.0 1.3 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 PIK41550.1 - 4.1e-27 93.9 0.1 1.3e-26 92.2 0.1 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 PIK41550.1 - 1.2e-25 90.5 0.5 4e-23 82.3 0.0 3.4 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain MG3 PF17791.1 PIK41550.1 - 8.3e-18 64.4 0.0 1e-16 61.0 0.0 2.9 3 0 0 3 3 3 1 Macroglobulin domain MG3 A2M_recep PF07677.14 PIK41550.1 - 3e-16 59.9 2.3 7.3e-16 58.7 1.0 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain MG2 PF01835.19 PIK41550.1 - 1e-15 58.0 0.0 2.3e-13 50.4 0.0 3.1 3 0 0 3 3 3 1 MG2 domain MG4 PF17789.1 PIK41550.1 - 3.1e-08 33.7 0.0 1.3e-07 31.7 0.0 2.0 1 0 0 1 1 1 1 Macroglobulin domain MG4 SVA PF05326.11 PIK41550.1 - 0.16 12.0 0.0 0.75 9.8 0.0 2.1 2 0 0 2 2 2 0 Seminal vesicle autoantigen (SVA) TPR_14 PF13428.6 PIK41551.1 - 1.5e-05 25.4 0.4 0.41 11.6 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 PIK41551.1 - 0.0048 16.1 0.2 0.0048 16.1 0.2 3.1 4 0 0 4 4 4 1 NRDE-2, necessary for RNA interference TPR_7 PF13176.6 PIK41551.1 - 0.036 14.1 0.0 37 4.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat CH_2 PF06294.11 PIK41552.1 - 2.7e-32 110.7 0.0 5.3e-32 109.8 0.0 1.5 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 PIK41552.1 - 1e-14 54.1 0.0 2.4e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.31 PIK41552.1 - 0.076 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Calponin homology (CH) domain RFXA_RFXANK_bdg PF15289.6 PIK41552.1 - 0.094 13.1 0.3 0.094 13.1 0.3 2.1 2 0 0 2 2 2 0 Regulatory factor X-associated C-terminal binding domain dCMP_cyt_deam_1 PF00383.23 PIK41553.1 - 2.6e-16 59.4 1.3 3.3e-15 55.8 1.3 2.0 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 PIK41553.1 - 1.8e-08 34.2 0.3 6.6e-08 32.4 0.3 1.8 1 1 0 1 1 1 1 MafB19-like deaminase DUF5479 PF17575.2 PIK41553.1 - 0.14 12.7 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5479) SGS PF05002.15 PIK41554.1 - 1.2e-29 102.2 3.6 1.2e-29 102.2 3.6 2.0 2 0 0 2 2 1 1 SGS domain CS PF04969.16 PIK41554.1 - 2.3e-14 54.2 0.3 4.7e-14 53.2 0.3 1.6 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 PIK41554.1 - 8.1e-12 44.3 5.5 0.009 16.1 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41554.1 - 1.5e-11 43.6 4.9 0.0019 18.0 0.4 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK41554.1 - 2e-08 34.8 3.6 0.00044 20.8 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK41554.1 - 1.5e-05 25.2 1.1 2.9e-05 24.2 1.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK41554.1 - 2e-05 24.2 2.9 0.036 13.8 0.4 3.1 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 PIK41554.1 - 6.2e-05 23.4 2.9 0.026 15.0 0.7 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41554.1 - 0.00028 20.9 3.7 3.6 8.0 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41554.1 - 0.002 18.0 2.5 1.2 9.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK41554.1 - 0.0038 17.5 5.9 0.0096 16.2 1.5 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK41554.1 - 0.012 16.4 2.6 8.6 7.5 0.1 3.4 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK41554.1 - 0.015 15.6 0.2 0.053 13.9 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 PIK41554.1 - 0.065 13.3 2.7 1.4 8.9 0.0 2.5 1 1 1 2 2 2 0 Putative TPR-like repeat DUF2018 PF09442.10 PIK41554.1 - 0.099 13.6 0.5 0.21 12.6 0.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF2018) MIT PF04212.18 PIK41554.1 - 0.36 10.9 10.1 0.64 10.1 2.3 3.6 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 PIK41554.1 - 1.4 9.8 5.0 79 4.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-Tim10_DDP PF02953.15 PIK41555.1 - 3.9e-13 48.8 1.7 3.9e-13 48.8 1.7 1.5 2 0 0 2 2 2 1 Tim10/DDP family zinc finger MFS_1_like PF12832.7 PIK41556.1 - 1.6e-39 135.9 1.2 2.2e-39 135.4 1.2 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK41556.1 - 2e-08 33.6 12.8 7.2e-05 21.9 0.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 PIK41556.1 - 1.5e-07 30.5 6.1 0.00082 18.3 0.2 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter DUF3894 PF13033.6 PIK41556.1 - 2.9 8.1 7.4 0.24 11.5 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3894) MFS_1_like PF12832.7 PIK41557.1 - 8.7e-19 67.6 3.1 9.6e-19 67.5 3.1 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK41557.1 - 0.0031 16.5 7.9 0.0034 16.4 7.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Nuc_H_symport PF03825.16 PIK41557.1 - 0.013 14.5 0.3 0.015 14.4 0.3 1.0 1 0 0 1 1 1 0 Nucleoside H+ symporter Sugar_tr PF00083.24 PIK41557.1 - 0.11 11.3 4.0 1.3 7.8 0.3 1.9 1 1 1 2 2 2 0 Sugar (and other) transporter Lectin_C PF00059.21 PIK41558.1 - 2.3e-10 41.2 0.1 1e-09 39.0 0.1 2.2 1 0 0 1 1 1 1 Lectin C-type domain PAN_1 PF00024.26 PIK41558.1 - 9.3e-08 31.9 1.8 3e-07 30.3 1.8 1.9 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 PIK41558.1 - 5.3e-05 23.0 1.0 0.00023 21.0 1.0 2.2 1 0 0 1 1 1 1 PAN domain DUF2205 PF10224.9 PIK41559.1 - 4.3e-26 90.7 4.0 5.9e-26 90.3 2.6 1.7 1 1 1 2 2 2 1 Short coiled-coil protein FlaC_arch PF05377.11 PIK41559.1 - 0.017 15.5 2.6 0.017 15.5 2.6 1.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 PIK41559.1 - 0.02 15.3 2.7 0.02 15.3 1.6 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) YabA PF06156.13 PIK41559.1 - 0.027 15.1 1.3 0.027 15.1 1.3 1.7 1 1 1 2 2 2 0 Initiation control protein YabA KASH_CCD PF14662.6 PIK41559.1 - 0.036 13.9 6.0 0.4 10.5 0.4 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 PIK41559.1 - 0.044 13.9 1.5 0.044 13.9 1.5 2.0 2 0 0 2 2 2 0 bZIP transcription factor HALZ PF02183.18 PIK41559.1 - 0.054 13.7 4.4 0.5 10.6 2.5 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper KBP_C PF12309.8 PIK41559.1 - 0.058 12.9 0.4 0.069 12.7 0.4 1.0 1 0 0 1 1 1 0 KIF-1 binding protein C terminal HSBP1 PF06825.12 PIK41559.1 - 0.074 12.9 1.3 2.2 8.2 0.1 2.7 3 0 0 3 3 3 0 Heat shock factor binding protein 1 ZapB PF06005.12 PIK41559.1 - 0.093 13.2 2.2 0.11 12.9 0.9 1.7 1 1 1 2 2 2 0 Cell division protein ZapB V_ATPase_I PF01496.19 PIK41559.1 - 0.1 10.5 1.5 0.12 10.3 1.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family JIP_LZII PF16471.5 PIK41559.1 - 0.31 11.2 7.4 0.36 11.0 1.6 2.3 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II zf-HC5HC2H_2 PF13832.6 PIK41560.1 - 2.5e-30 104.9 6.5 2.5e-30 104.9 6.5 2.9 2 1 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 PIK41560.1 - 1.5e-26 92.5 3.8 1.5e-26 92.5 3.8 4.0 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 PIK41560.1 - 1.4e-11 43.7 10.3 1.4e-11 43.7 10.3 3.0 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 PIK41560.1 - 1e-08 35.7 2.9 1e-08 35.7 2.9 7.6 3 2 0 3 3 3 1 Enhancer of polycomb-like PHD PF00628.29 PIK41560.1 - 4.1e-07 29.8 35.9 8.8e-07 28.7 16.4 3.3 3 0 0 3 3 3 2 PHD-finger Homeodomain PF00046.29 PIK41561.1 - 3.6e-23 81.2 4.7 6.6e-23 80.3 4.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK41561.1 - 0.0022 17.9 0.2 0.005 16.7 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain DUF4551 PF15087.6 PIK41561.1 - 1.3 7.8 7.2 1.4 7.6 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SRP-alpha_N PF04086.13 PIK41561.1 - 2.6 7.9 23.9 3.5 7.5 23.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MAP65_ASE1 PF03999.12 PIK41561.1 - 3 6.4 11.9 4.6 5.8 11.9 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RMI1_N PF08585.12 PIK41562.1 - 2.5e-20 73.2 1.3 1.6e-17 64.0 0.5 2.4 2 1 1 3 3 3 2 RecQ mediated genome instability protein Cytomega_UL84 PF06284.11 PIK41563.1 - 0.14 10.5 3.4 0.21 10.0 3.4 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Sir1 PF11603.8 PIK41563.1 - 0.16 12.5 0.0 0.24 11.9 0.0 1.2 1 0 0 1 1 1 0 Regulatory protein Sir1 Pneumo_att_G PF05539.11 PIK41563.1 - 4.5 6.8 5.5 5.3 6.5 5.5 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Glucosamine_iso PF01182.20 PIK41564.1 - 8.9e-19 68.3 0.0 1.2e-18 67.9 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AAA_2 PF07724.14 PIK41565.1 - 1.6e-42 145.5 0.3 2.9e-42 144.7 0.3 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Ank_2 PF12796.7 PIK41565.1 - 3.7e-17 62.7 0.0 5.9e-10 39.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK41565.1 - 9.8e-14 51.5 2.7 9.4e-07 29.3 0.0 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK41565.1 - 1e-13 50.1 0.2 0.00027 21.1 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 PIK41565.1 - 3.8e-13 49.2 0.2 2.3e-05 24.6 0.0 3.8 4 0 0 4 4 3 2 Ankyrin repeat ClpB_D2-small PF10431.9 PIK41565.1 - 7.9e-11 41.9 0.1 3.9e-10 39.6 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Ank_5 PF13857.6 PIK41565.1 - 2e-10 40.7 0.7 0.0014 18.9 0.0 3.7 3 1 1 4 4 3 3 Ankyrin repeats (many copies) AAA_5 PF07728.14 PIK41565.1 - 6.1e-10 39.2 0.0 2.3e-09 37.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 PIK41565.1 - 1.8e-08 34.9 0.1 1.6e-07 31.8 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK41565.1 - 4.5e-06 26.5 0.0 9.3e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 PIK41565.1 - 0.00018 22.0 0.0 0.0072 16.7 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain YchF-GTPase_C PF06071.13 PIK41565.1 - 0.00048 20.2 0.4 0.0021 18.2 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF933) Torsin PF06309.11 PIK41565.1 - 0.00055 20.0 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 Torsin AAA_3 PF07726.11 PIK41565.1 - 0.0015 18.4 0.0 0.023 14.5 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK41565.1 - 0.0017 17.7 0.0 0.0043 16.4 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.6 PIK41565.1 - 0.005 16.6 0.0 0.0098 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 PIK41565.1 - 0.011 14.9 0.1 0.13 11.5 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.6 PIK41565.1 - 0.015 15.6 0.0 0.098 12.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK41565.1 - 0.026 15.1 0.0 0.079 13.5 0.0 1.9 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 PIK41565.1 - 0.032 14.6 0.2 0.18 12.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 PIK41565.1 - 0.037 13.9 0.6 0.19 11.6 0.1 2.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea RuvB_N PF05496.12 PIK41565.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 PIK41565.1 - 0.11 12.5 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.22 PIK41565.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DNA_pol3_delta2 PF13177.6 PIK41566.1 - 9.2e-10 38.5 1.1 1.6e-09 37.8 0.1 1.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 PIK41566.1 - 3.2e-07 30.8 0.0 7.9e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 PIK41566.1 - 5.9e-06 26.3 0.2 1.7e-05 24.9 0.1 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 PIK41566.1 - 0.00015 21.6 0.5 0.00028 20.7 0.5 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 PIK41566.1 - 0.0033 17.8 0.1 0.014 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Rep_fac_C PF08542.11 PIK41566.1 - 0.014 15.8 0.3 0.033 14.6 0.1 1.8 2 0 0 2 2 1 0 Replication factor C C-terminal domain ATPgrasp_ST PF14397.6 PIK41566.1 - 0.035 13.4 0.1 0.056 12.7 0.1 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp RuvB_N PF05496.12 PIK41566.1 - 0.075 12.8 0.0 3.9 7.2 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 PIK41566.1 - 0.076 13.1 0.1 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 PIK41566.1 - 0.085 13.1 0.1 0.58 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 PIK41566.1 - 0.091 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Bac_DnaA PF00308.18 PIK41566.1 - 0.11 12.3 0.2 1.2 9.0 0.1 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein T4SS-DNA_transf PF02534.14 PIK41566.1 - 0.12 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer HECT PF00632.25 PIK41567.1 - 1.3e-46 159.5 1.1 1.7e-46 159.2 1.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DED PF01335.21 PIK41569.1 - 9.1e-09 35.5 0.0 1.8e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Death effector domain Methyltransf_32 PF13679.6 PIK41570.1 - 2e-30 105.9 1.8 1.5e-29 103.1 1.8 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK41570.1 - 2e-05 24.5 0.0 4.6e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK41570.1 - 0.00016 22.2 0.0 0.00044 20.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK41570.1 - 0.00028 21.5 0.0 0.00081 20.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41570.1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK41570.1 - 0.0041 16.5 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK41570.1 - 0.0064 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 PIK41570.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 PIK41570.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_18 PF12847.7 PIK41570.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CD225 PF04505.12 PIK41572.1 - 4.8e-20 71.5 0.0 8.3e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Rep_fac-A_C PF08646.10 PIK41573.1 - 6.5e-07 29.2 11.6 2.2e-05 24.2 8.6 2.6 2 1 0 2 2 2 2 Replication factor-A C terminal domain zf-ribbon_3 PF13248.6 PIK41573.1 - 0.0056 16.0 1.0 0.0056 16.0 1.0 2.8 3 0 0 3 3 3 1 zinc-ribbon domain REPA_OB_2 PF16900.5 PIK41573.1 - 0.0063 16.4 0.4 0.016 15.1 0.4 1.7 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 PIK41573.1 - 0.0068 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Prefoldin PF02996.17 PIK41574.1 - 1e-30 106.1 0.2 1e-30 106.1 0.2 1.5 2 0 0 2 2 2 1 Prefoldin subunit DivIVA PF05103.13 PIK41574.1 - 0.087 12.9 2.7 1.9 8.6 1.0 2.2 2 0 0 2 2 2 0 DivIVA protein DUF5131 PF07505.11 PIK41574.1 - 0.093 12.2 1.7 0.21 11.0 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF5131) HTH_Tnp_1_2 PF13022.6 PIK41574.1 - 0.11 12.6 3.2 0.27 11.4 0.5 2.3 2 1 1 3 3 3 0 Helix-turn-helix of insertion element transposase Sugar_tr PF00083.24 PIK41575.1 - 1.2e-20 73.8 18.8 1.8e-20 73.3 18.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK41575.1 - 2.9e-15 56.1 31.6 1.7e-09 37.1 16.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1440 PF07274.12 PIK41575.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1440) Profilin PF00235.19 PIK41576.1 - 2.6e-31 108.5 0.0 4e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Profilin K1377 PF15352.6 PIK41578.1 - 2e-11 43.0 10.7 4.1e-11 41.9 4.6 2.3 2 1 0 2 2 2 2 Susceptibility to monomelic amyotrophy Med19 PF10278.9 PIK41578.1 - 0.0023 17.9 0.1 0.0023 17.9 0.1 2.2 1 1 1 2 2 2 1 Mediator of RNA pol II transcription subunit 19 Tubulin PF00091.25 PIK41580.1 - 1.5e-44 152.6 0.0 2e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41580.1 - 9.8e-20 71.0 0.0 1.9e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41580.1 - 0.0022 17.7 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41582.1 - 5e-69 232.5 0.0 6.4e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41582.1 - 1.3e-42 145.0 0.0 2.2e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41582.1 - 0.00055 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41583.1 - 9e-67 225.1 0.0 1.2e-66 224.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41583.1 - 2.8e-52 176.2 0.0 4.4e-52 175.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41583.1 - 0.0013 18.4 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41584.1 - 6.8e-43 147.2 0.0 9.4e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41584.1 - 2.9e-16 59.8 0.0 5.1e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41584.1 - 0.00061 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41585.1 - 1.1e-19 71.5 0.0 1.3e-19 71.2 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin PF00091.25 PIK41586.1 - 1.5e-63 214.5 0.0 2e-63 214.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41586.1 - 6.7e-43 145.8 0.0 1.1e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41586.1 - 0.0016 18.1 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41587.1 - 6.9e-68 228.7 0.0 9.4e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41587.1 - 5.1e-52 175.3 0.0 8e-52 174.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41587.1 - 0.00094 18.9 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41588.1 - 6.6e-68 228.8 0.0 9.8e-68 228.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41588.1 - 6.2e-51 171.8 0.0 9.6e-51 171.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41588.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 PIK41589.1 - 1.6e-67 227.5 0.0 2.5e-67 226.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK41589.1 - 3.8e-44 149.9 0.0 6.7e-44 149.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK41589.1 - 0.00063 19.5 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 PIK41589.1 - 0.029 13.6 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Tubulin like 7tm_1 PF00001.21 PIK41591.1 - 4.1e-31 108.3 4.3 4.1e-31 108.3 4.3 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41591.1 - 1.1e-14 54.7 5.2 1.4e-14 54.4 5.2 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK41591.1 - 7.3e-07 28.8 4.1 9.6e-07 28.4 4.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF621 PF04789.15 PIK41591.1 - 0.0011 18.2 7.5 0.0013 18.0 7.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF621) DUF4321 PF14209.6 PIK41591.1 - 0.071 13.0 1.2 0.071 13.0 1.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4321) Git3 PF11710.8 PIK41591.1 - 0.16 11.7 13.0 0.25 11.1 13.0 1.2 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 7tm_4 PF13853.6 PIK41591.1 - 0.31 10.7 11.3 9.3 5.9 11.3 2.1 1 1 0 1 1 1 0 Olfactory receptor YL1_C PF08265.11 PIK41592.1 - 4.6e-09 35.9 0.0 8.5e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Methyltransf_23 PF13489.6 PIK41593.1 - 6.5e-16 58.6 0.0 1.1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK41593.1 - 1.1e-14 54.9 0.0 5.1e-14 52.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK41593.1 - 2.9e-13 50.3 0.0 7.3e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK41593.1 - 1.9e-10 41.3 0.0 4e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41593.1 - 2.7e-08 33.7 0.0 6.3e-08 32.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Dpy19 PF10034.9 PIK41594.1 - 2.1e-134 449.2 3.6 2.4e-134 449.0 3.6 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation LpxI_N PF17930.1 PIK41594.1 - 0.008 16.1 0.0 2.8 7.8 0.0 2.9 3 0 0 3 3 3 2 LpxI N-terminal domain STIMATE PF12400.8 PIK41594.1 - 2.8 8.5 12.0 2.4 8.7 0.3 3.2 2 2 1 4 4 4 0 STIMATE family EF1_GNE PF00736.19 PIK41595.1 - 1.4e-30 105.3 0.6 3e-30 104.3 0.3 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain GST_C_3 PF14497.6 PIK41595.1 - 0.084 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Molybdopterin PF00384.22 PIK41596.1 - 3.7e-27 95.4 0.0 7.7e-26 91.0 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 PIK41596.1 - 3e-17 62.4 0.1 7.1e-17 61.2 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 PIK41596.1 - 1.1e-16 60.1 0.1 3.3e-16 58.5 0.1 1.9 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 PIK41596.1 - 2.4e-09 37.0 0.6 2.4e-09 37.0 0.6 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 PIK41596.1 - 0.001 18.8 0.1 0.55 10.0 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 PIK41596.1 - 0.22 11.4 1.5 8.4 6.4 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Molybdopterin PF00384.22 PIK41597.1 - 2.6e-22 79.4 0.0 3.7e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 PIK41597.1 - 3.2e-18 66.1 0.4 5.5e-18 65.4 0.4 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal PTPLA PF04387.14 PIK41597.1 - 0.061 13.1 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA Ras PF00071.22 PIK41598.1 - 8.7e-53 178.2 0.0 1.1e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41598.1 - 1.2e-20 73.9 0.0 1.9e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK41598.1 - 5.8e-07 29.1 0.0 8.8e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK41598.1 - 2.3e-06 27.3 0.0 4e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Parecho_VpG PF06344.11 PIK41598.1 - 0.00015 22.0 2.6 88 4.1 0.0 6.0 5 1 1 6 6 6 0 Parechovirus Genome-linked protein RsgA_GTPase PF03193.16 PIK41598.1 - 0.02 14.8 0.0 5.7 6.8 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 PIK41598.1 - 0.028 14.2 0.5 0.066 13.0 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pertussis_S2S3 PF02918.15 PIK41598.1 - 0.13 12.2 0.0 44 4.0 0.0 3.3 2 1 1 3 3 3 0 Pertussis toxin, subunit 2 and 3, C-terminal domain Thioredoxin PF00085.20 PIK41599.1 - 3e-18 65.7 0.1 4.9e-18 65.0 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 PIK41599.1 - 8.4e-05 22.6 0.0 0.00031 20.7 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 PIK41599.1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK41599.1 - 0.0042 17.5 0.2 0.018 15.5 0.1 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK41599.1 - 0.0058 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 PIK41599.1 - 0.025 14.5 0.0 0.059 13.3 0.1 1.6 2 0 0 2 2 2 0 AhpC/TSA family Redoxin PF08534.10 PIK41599.1 - 0.073 12.8 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Redoxin Thioredoxin PF00085.20 PIK41600.1 - 5.7e-57 190.1 0.0 9.8e-30 102.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 PIK41600.1 - 1.1e-14 54.7 0.0 5.5e-09 36.2 0.1 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK41600.1 - 1.2e-10 41.6 0.5 0.034 14.5 0.0 5.3 4 2 2 6 6 5 2 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK41600.1 - 2.2e-10 40.9 1.7 0.00089 19.7 0.1 3.8 2 2 1 3 3 3 2 Thioredoxin-like domain AhpC-TSA PF00578.21 PIK41600.1 - 1.8e-08 34.3 0.3 0.018 14.9 0.0 3.6 4 0 0 4 4 4 2 AhpC/TSA family Calsequestrin PF01216.17 PIK41600.1 - 5.7e-08 32.2 0.2 1.1e-06 28.0 0.2 2.3 1 1 1 2 2 2 1 Calsequestrin Thioredoxin_7 PF13899.6 PIK41600.1 - 4.2e-07 30.0 0.1 0.023 14.8 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 PIK41600.1 - 3e-05 23.5 0.0 0.0038 16.6 0.0 2.2 1 1 1 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 PIK41600.1 - 0.0013 18.8 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin domain Redoxin PF08534.10 PIK41600.1 - 0.0075 16.0 0.1 4.2 7.1 0.0 2.6 2 0 0 2 2 2 2 Redoxin HyaE PF07449.11 PIK41600.1 - 0.011 15.7 0.0 5.8 6.9 0.0 2.9 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 PIK41600.1 - 0.015 15.1 0.0 1.8 8.3 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin Glyco_hydro_72 PF03198.14 PIK41600.1 - 0.087 12.1 0.0 0.66 9.2 0.0 2.0 2 0 0 2 2 2 0 Glucanosyltransferase Thioredoxin_4 PF13462.6 PIK41600.1 - 0.12 12.5 0.1 17 5.5 0.0 2.8 2 1 0 3 3 3 0 Thioredoxin 7tm_1 PF00001.21 PIK41601.1 - 7.1e-26 91.1 10.2 9.1e-26 90.7 10.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK41601.1 - 3.6e-09 36.7 13.0 4.1e-09 36.4 13.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK41601.1 - 1.6e-06 27.7 10.3 2.3e-06 27.2 10.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK41601.1 - 4.8e-06 26.1 10.8 6.1e-06 25.8 10.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx WD40 PF00400.32 PIK41602.1 - 2e-11 44.2 22.4 0.00013 22.7 0.2 5.9 6 2 0 6 6 6 3 WD domain, G-beta repeat F-box-like PF12937.7 PIK41602.1 - 1.3e-05 24.9 0.3 4.1e-05 23.4 0.2 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK41602.1 - 0.001 18.9 0.1 0.0031 17.4 0.1 1.8 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 PIK41602.1 - 0.0015 18.8 1.6 5.7 7.3 0.1 4.5 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Elongin_A PF06881.11 PIK41602.1 - 0.042 14.4 0.3 3.9 8.1 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RhoGAP PF00620.27 PIK41604.1 - 1.1e-24 87.0 0.1 1.5e-24 86.6 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain LPMO_10 PF03067.15 PIK41605.1 - 0.0087 16.7 0.0 0.012 16.3 0.0 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading F420_oxidored PF03807.17 PIK41608.1 - 5.5e-09 36.5 0.0 8e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent P5CR_dimer PF14748.6 PIK41609.1 - 6.4e-26 90.6 0.4 7e-26 90.5 0.4 1.0 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation SOUL PF04832.12 PIK41611.1 - 3.6e-39 134.6 2.8 6.2e-27 94.8 0.1 2.0 2 0 0 2 2 2 2 SOUL heme-binding protein SOUL PF04832.12 PIK41612.1 - 4.8e-08 33.4 0.0 5.6e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein NACHT PF05729.12 PIK41615.1 - 1.1e-12 48.2 0.1 4.8e-12 46.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK41615.1 - 7.2e-05 22.5 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF3368 PF11848.8 PIK41615.1 - 0.0061 16.3 0.3 0.24 11.2 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3368) AAA_22 PF13401.6 PIK41615.1 - 0.0098 16.2 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain GPI2 PF06432.11 PIK41615.1 - 0.058 12.8 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase DAP3 PF10236.9 PIK41615.1 - 0.068 12.3 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF563 PF04577.14 PIK41616.1 - 1.5e-13 51.4 0.0 2.4e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) FtsL PF04999.13 PIK41616.1 - 0.0068 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Cell division protein FtsL SOUL PF04832.12 PIK41617.1 - 1e-24 87.6 0.1 1.3e-24 87.3 0.1 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein NACHT PF05729.12 PIK41618.1 - 0.00037 20.4 0.0 0.00097 19.1 0.0 1.6 2 0 0 2 2 2 1 NACHT domain GPI2 PF06432.11 PIK41618.1 - 0.047 13.1 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF3368 PF11848.8 PIK41618.1 - 0.15 11.8 0.4 0.6 9.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) DUF563 PF04577.14 PIK41619.1 - 1e-13 51.9 0.0 1.7e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) FtsL PF04999.13 PIK41619.1 - 0.042 13.8 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 Cell division protein FtsL CDC73_N PF16050.5 PIK41620.1 - 7.8e-120 399.6 9.7 9.9e-120 399.3 9.7 1.1 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 PIK41620.1 - 8.8e-50 168.4 0.2 2.6e-49 166.9 0.2 1.8 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal SAM_PNT PF02198.16 PIK41621.1 - 1.6e-28 98.5 0.1 2.7e-28 97.7 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ets PF00178.22 PIK41622.1 - 7.3e-12 45.6 1.5 9e-12 45.3 1.5 1.1 1 0 0 1 1 1 1 Ets-domain DUF155 PF02582.14 PIK41623.1 - 0.0028 17.8 0.4 0.035 14.2 0.0 2.3 1 1 2 3 3 3 1 Uncharacterised ACR, YagE family COG1723 PhaP_Bmeg PF09602.10 PIK41623.1 - 0.0073 16.3 0.3 0.015 15.3 0.3 1.6 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF3510 PF12022.8 PIK41623.1 - 0.021 15.2 0.5 0.6 10.5 0.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) DUF5100 PF17029.5 PIK41623.1 - 0.073 12.9 2.7 1.9 8.3 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF5100) Exog_C PF18026.1 PIK41623.1 - 0.074 13.1 0.1 15 5.8 0.0 3.4 4 0 0 4 4 4 0 Endo/exonuclease (EXOG) C-terminal domain DUF1494 PF07379.11 PIK41623.1 - 0.081 12.8 0.1 5.1 6.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1494) ParcG PF10274.9 PIK41623.1 - 0.12 12.5 0.5 2.1 8.4 0.2 2.2 1 1 1 2 2 2 0 Parkin co-regulated protein CSTF2_hinge PF14327.6 PIK41623.1 - 3.6 8.1 6.6 1 9.9 0.2 2.8 4 0 0 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 Ribosomal_S19e PF01090.19 PIK41624.1 - 5.7e-31 107.1 4.1 7.9e-30 103.4 1.7 2.1 1 1 1 2 2 2 2 Ribosomal protein S19e HTH_12 PF08461.10 PIK41624.1 - 0.034 14.1 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain ThiP_synth PF10120.9 PIK41624.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Thiamine-phosphate synthase IFT57 PF10498.9 PIK41625.1 - 1.1e-153 511.5 8.3 1.3e-153 511.3 8.3 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF1664 PF07889.12 PIK41625.1 - 0.001 19.1 9.4 0.0074 16.3 2.7 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF1664) Spc7 PF08317.11 PIK41625.1 - 0.0014 17.6 11.3 0.0014 17.6 11.3 2.2 1 1 0 2 2 2 1 Spc7 kinetochore protein HBM PF16591.5 PIK41625.1 - 0.0084 15.6 1.4 0.0084 15.6 1.4 2.0 1 1 0 1 1 1 1 Helical bimodular sensor domain BLOC1_2 PF10046.9 PIK41625.1 - 0.012 15.8 4.1 0.27 11.6 2.4 2.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 PIK41625.1 - 0.016 15.2 3.2 0.35 10.9 0.8 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.11 PIK41625.1 - 0.058 13.2 0.1 0.058 13.2 0.1 2.6 2 2 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Exonuc_VII_L PF02601.15 PIK41625.1 - 0.064 12.8 7.9 0.098 12.2 7.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit WXG100 PF06013.12 PIK41625.1 - 0.077 13.2 3.7 1.1 9.5 0.5 3.7 2 1 1 3 3 3 0 Proteins of 100 residues with WXG HAD_2 PF13419.6 PIK41625.1 - 0.17 11.9 3.7 1.5 8.9 0.6 2.7 1 1 2 3 3 3 0 Haloacid dehalogenase-like hydrolase TPR_MLP1_2 PF07926.12 PIK41625.1 - 0.19 11.8 13.5 1.2 9.2 5.6 3.5 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein COG2 PF06148.11 PIK41625.1 - 0.2 11.8 13.3 1.5 8.9 0.2 3.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 T3SS_basalb_I PF17001.5 PIK41625.1 - 0.22 12.2 4.7 7.2 7.3 0.1 3.2 1 1 2 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI Lebercilin PF15619.6 PIK41625.1 - 0.25 11.0 21.3 0.021 14.5 16.0 2.0 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 PIK41625.1 - 0.5 10.9 9.1 8.2 7.0 0.1 3.8 2 1 2 4 4 3 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 PIK41625.1 - 0.67 10.2 11.8 1 9.6 3.0 3.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Sec34 PF04136.15 PIK41625.1 - 1 9.3 6.5 2.2 8.2 3.9 2.5 1 1 0 1 1 1 0 Sec34-like family TMPIT PF07851.13 PIK41625.1 - 1.2 8.3 13.1 0.37 10.0 1.8 2.3 1 1 1 2 2 2 0 TMPIT-like protein Occludin_ELL PF07303.13 PIK41625.1 - 1.7 9.4 7.6 11 6.8 0.9 3.1 1 1 2 3 3 3 0 Occludin homology domain Fez1 PF06818.15 PIK41625.1 - 1.8 9.0 23.2 0.037 14.5 9.8 2.8 1 1 2 3 3 3 0 Fez1 FapA PF03961.13 PIK41625.1 - 2 6.9 12.8 1 7.9 2.2 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A KxDL PF10241.9 PIK41625.1 - 2.3 8.5 8.7 4.5 7.6 1.2 3.2 1 1 4 5 5 5 0 Uncharacterized conserved protein CENP-H PF05837.12 PIK41625.1 - 2.4 8.6 9.7 0.58 10.6 4.2 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FliJ PF02050.16 PIK41625.1 - 2.6 8.3 9.8 2.8 8.2 3.2 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein COG5 PF10392.9 PIK41625.1 - 3.8 7.7 11.3 6.3 7.0 2.2 3.2 1 1 2 3 3 3 0 Golgi transport complex subunit 5 HIP1_clath_bdg PF16515.5 PIK41625.1 - 6.3 7.5 20.9 2.9 8.6 2.1 3.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Laminin_II PF06009.12 PIK41625.1 - 7.3 6.6 15.2 0.15 12.1 4.1 3.4 3 1 2 5 5 3 0 Laminin Domain II Fib_alpha PF08702.10 PIK41625.1 - 9.5 6.4 15.4 1.1 9.5 6.7 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family RNA_pol_Rpb8 PF03870.15 PIK41626.1 - 1.2e-24 87.0 0.0 1.4e-24 86.8 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 DUF5526 PF17664.1 PIK41627.1 - 2.3e-28 98.9 2.7 3e-28 98.5 2.7 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5526) TAP42 PF04177.12 PIK41627.1 - 0.038 13.1 6.0 0.048 12.8 6.0 1.1 1 0 0 1 1 1 0 TAP42-like family YccJ PF13993.6 PIK41627.1 - 0.2 12.0 2.0 0.28 11.5 0.4 2.1 3 0 0 3 3 3 0 YccJ-like protein Endotoxin_N PF03945.14 PIK41628.1 - 0.1 12.3 2.0 7.5 6.2 0.1 2.5 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain Ig_3 PF13927.6 PIK41629.1 - 6.9e-13 49.0 0.6 4.7e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41629.1 - 4.4e-12 46.2 0.1 3.6e-06 27.2 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41629.1 - 4.8e-11 42.6 0.5 0.00031 20.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK41629.1 - 2.5e-08 34.0 1.3 0.002 18.3 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK41629.1 - 8.3e-05 22.7 0.0 0.006 16.7 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK41629.1 - 0.0015 18.9 0.1 0.026 14.9 0.0 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ly-6_related PF06579.12 PIK41629.1 - 0.0049 17.1 3.8 0.02 15.1 3.8 1.9 1 1 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein PKD PF00801.20 PIK41629.1 - 0.071 13.0 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 PKD domain DUF5018 PF16410.5 PIK41631.1 - 0.046 12.4 0.0 0.067 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) Diphtheria_R PF01324.19 PIK41631.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Diphtheria toxin, R domain PHO4 PF01384.20 PIK41633.1 - 1.6e-61 208.2 6.4 1.8e-61 208.0 6.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family PHO4 PF01384.20 PIK41634.1 - 1.2e-42 146.2 8.9 1.9e-42 145.5 8.9 1.3 1 0 0 1 1 1 1 Phosphate transporter family DUF1269 PF06897.12 PIK41634.1 - 0.022 15.1 0.6 0.022 15.1 0.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) WW PF00397.26 PIK41636.1 - 1e-06 28.7 0.2 2e-06 27.8 0.2 1.5 1 0 0 1 1 1 1 WW domain Ribosomal_S24e PF01282.19 PIK41638.1 - 6.9e-39 131.7 0.1 6.9e-39 131.7 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S24e PARG_cat PF05028.14 PIK41639.1 - 5e-137 456.7 0.0 7e-137 456.2 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DBB PF14545.6 PIK41640.1 - 4.7e-19 68.7 0.0 7e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, Ank_2 PF12796.7 PIK41640.1 - 0.0094 16.5 0.1 0.017 15.7 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK41640.1 - 0.0099 16.3 0.1 0.054 14.0 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 PIK41640.1 - 0.01 16.1 0.0 0.025 14.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DASH_Hsk3 PF08227.11 PIK41640.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like zf-met2 PF12907.7 PIK41640.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding Ank_3 PF13606.6 PIK41640.1 - 0.11 13.1 0.0 0.36 11.5 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat RVT_1 PF00078.27 PIK41641.1 - 6.7e-18 65.0 0.1 2.5e-15 56.6 0.1 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RasGEF PF00617.19 PIK41643.1 - 2.6e-37 128.8 0.0 4.9e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.24 PIK41643.1 - 2.2e-12 47.2 0.0 4.9e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RasGEF_N PF00618.20 PIK41643.1 - 7.2e-11 42.3 0.3 1.2e-09 38.4 0.1 2.8 2 1 0 2 2 2 1 RasGEF N-terminal motif PDZ_6 PF17820.1 PIK41643.1 - 2.4e-10 40.1 0.0 6.2e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 PIK41643.1 - 2.3e-07 30.8 0.0 0.0026 17.8 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RA PF00788.23 PIK41643.1 - 1.7e-05 25.4 0.0 4.2e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.6 PIK41643.1 - 0.00047 20.4 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RhoGEF PF00621.20 PIK41644.1 - 5.4e-28 98.5 3.2 5.4e-28 98.5 3.2 2.1 2 0 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 PIK41644.1 - 1.7e-05 24.3 0.7 5.3e-05 22.7 0.7 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK41644.1 - 7.5e-05 22.3 0.1 0.00033 20.3 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain PH PF00169.29 PIK41644.1 - 8e-05 23.1 3.1 8.1e-05 23.1 1.2 2.0 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 PIK41644.1 - 0.00023 21.0 0.6 0.00065 19.5 0.6 1.8 1 0 0 1 1 1 1 Variant SH3 domain DUF1699 PF08004.11 PIK41644.1 - 0.012 15.2 0.1 0.04 13.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) SH3_16 PF18348.1 PIK41644.1 - 0.15 11.9 0.1 0.38 10.6 0.1 1.7 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Pkinase PF00069.25 PIK41645.1 - 1.3e-46 159.1 0.0 1.9e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41645.1 - 4.4e-23 81.9 0.0 6.2e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 PIK41645.1 - 1.1e-12 47.6 4.9 2.4e-12 46.5 4.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PB1 PF00564.24 PIK41645.1 - 8.2e-12 44.9 0.0 3.4e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 PB1 domain Pkinase_C PF00433.24 PIK41645.1 - 3.3e-07 30.9 1.1 9.1e-07 29.5 0.3 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain C1_2 PF03107.16 PIK41645.1 - 0.0081 16.5 2.7 0.019 15.3 2.7 1.6 1 0 0 1 1 1 1 C1 domain Haspin_kinase PF12330.8 PIK41645.1 - 0.015 14.3 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 PIK41645.1 - 0.087 12.7 0.0 0.23 11.4 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK41645.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK41645.1 - 0.19 11.0 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PHD_2 PF13831.6 PIK41645.1 - 0.27 10.8 4.0 0.66 9.6 4.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 PIK41645.1 - 0.64 10.4 6.5 1.5 9.2 6.5 1.6 1 0 0 1 1 1 0 RING-like domain DUF4287 PF14117.6 PIK41646.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Ufd2P_core PF10408.9 PIK41647.1 - 5.1e-183 610.1 17.7 7.4e-183 609.6 17.7 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 PIK41647.1 - 2.9e-26 91.4 0.3 1.3e-25 89.3 0.3 2.3 1 0 0 1 1 1 1 U-box domain YtzH PF14165.6 PIK41647.1 - 0.41 11.1 6.8 53 4.3 0.0 4.7 4 0 0 4 4 4 0 YtzH-like protein Pkinase PF00069.25 PIK41648.1 - 3.1e-15 56.3 0.0 4.8e-14 52.4 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41648.1 - 2.1e-05 24.0 0.0 0.037 13.3 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 PIK41648.1 - 0.036 14.0 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family EF-hand_1 PF00036.32 PIK41649.1 - 8e-15 53.2 3.6 7e-08 31.5 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK41649.1 - 6.5e-13 48.9 2.5 1.3e-12 47.9 2.5 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK41649.1 - 3.7e-10 38.9 1.6 2.1e-06 27.2 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK41649.1 - 2.1e-08 33.3 2.0 0.00048 19.5 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK41649.1 - 3e-05 23.8 4.3 0.035 14.0 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 PIK41649.1 - 0.0078 16.1 0.2 0.013 15.4 0.2 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 PIK41649.1 - 0.0088 16.9 0.0 0.013 16.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain Caleosin PF05042.13 PIK41649.1 - 0.0092 15.9 0.3 0.023 14.6 0.1 1.7 1 1 0 1 1 1 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 PIK41649.1 - 0.077 13.3 2.5 0.13 12.6 2.5 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Glyco_hydro_56 PF01630.18 PIK41651.1 - 4.6e-112 374.3 0.3 6e-112 374.0 0.3 1.1 1 0 0 1 1 1 1 Hyaluronidase Death PF00531.22 PIK41652.1 - 2e-10 40.7 0.0 3.3e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 Death domain HisK_N PF09385.10 PIK41652.1 - 0.04 13.9 0.2 0.052 13.5 0.2 1.3 1 0 0 1 1 1 0 Histidine kinase N terminal Dehydratase_LU PF02286.15 PIK41652.1 - 0.051 12.2 0.1 0.058 12.0 0.1 1.0 1 0 0 1 1 1 0 Dehydratase large subunit Death PF00531.22 PIK41653.1 - 0.018 15.2 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 Death domain THAP PF05485.12 PIK41654.1 - 3e-09 37.7 0.2 5.5e-09 36.8 0.2 1.6 1 1 0 1 1 1 1 THAP domain OAD_gamma PF04277.13 PIK41655.1 - 0.00011 22.7 0.2 0.00019 22.0 0.2 1.3 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain Shisa PF13908.6 PIK41655.1 - 0.00033 20.9 0.3 0.00068 19.9 0.3 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Phage_holin_3_6 PF07332.11 PIK41655.1 - 0.0032 17.5 0.1 0.0045 17.0 0.1 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III OSTbeta PF15048.6 PIK41655.1 - 0.0035 17.5 0.1 0.0066 16.6 0.1 1.4 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein Baculo_11_kDa PF06143.11 PIK41655.1 - 0.013 15.1 1.9 0.029 13.9 1.9 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family EphA2_TM PF14575.6 PIK41655.1 - 0.014 16.3 0.0 0.028 15.3 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1218 PF06749.12 PIK41655.1 - 0.04 14.4 0.0 0.083 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) DUF4834 PF16118.5 PIK41655.1 - 0.054 14.5 0.7 0.12 13.4 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) V-set PF07686.17 PIK41655.1 - 0.089 13.0 1.0 0.24 11.6 0.0 2.2 3 0 0 3 3 3 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41655.1 - 0.37 11.4 6.8 9.3 6.9 0.1 4.0 4 1 0 4 4 4 0 Immunoglobulin domain Glycoprotein_G PF00802.19 PIK41655.1 - 0.51 9.7 5.3 0.16 11.3 1.4 2.1 2 0 0 2 2 2 0 Pneumovirus attachment glycoprotein G XPG_I_2 PF12813.7 PIK41657.1 - 7.5e-10 38.7 0.0 9.9e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 PIK41657.1 - 2.4e-09 37.6 0.0 3.7e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 XPG N-terminal domain DUF1744 PF08490.12 PIK41658.1 - 2.5e-139 464.3 0.1 4.5e-139 463.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 PIK41658.1 - 1.6e-45 155.7 0.0 8.5e-45 153.3 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 PIK41658.1 - 5.2e-13 48.5 0.2 1.1e-11 44.1 0.1 2.8 3 1 0 3 3 3 1 DNA polymerase family B DUF4379 PF14311.6 PIK41658.1 - 0.12 12.7 2.2 15 6.1 0.0 2.8 2 0 0 2 2 2 0 Probable Zinc-ribbon domain NAPRTase_C PF17956.1 PIK41658.1 - 0.13 12.7 0.1 2.6 8.5 0.0 2.6 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain HYR PF02494.16 PIK41659.1 - 1.2e-10 41.6 6.7 6.8e-07 29.5 2.1 3.2 3 0 0 3 3 3 3 HYR domain Cry1Ac_D5 PF17997.1 PIK41659.1 - 0.27 11.1 1.7 1.9 8.3 0.5 2.2 2 0 0 2 2 2 0 Insecticidal delta-endotoxin CryIA(c) domain 5 EGF PF00008.27 PIK41660.1 - 7.1e-14 51.8 85.5 3.1e-06 27.4 5.6 7.1 6 2 1 7 7 7 5 EGF-like domain HYR PF02494.16 PIK41660.1 - 1.1e-13 51.3 0.8 2.1e-13 50.4 0.8 1.4 1 0 0 1 1 1 1 HYR domain hEGF PF12661.7 PIK41660.1 - 1.1e-05 25.8 32.6 0.0015 19.1 6.8 9.6 8 4 0 8 8 8 4 Human growth factor-like EGF cEGF PF12662.7 PIK41660.1 - 0.0064 16.4 0.7 0.0064 16.4 0.7 7.1 5 2 0 5 5 5 2 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK41660.1 - 0.012 15.9 9.7 0.012 15.9 9.7 6.4 5 2 0 5 5 5 0 EGF-like domain HYR PF02494.16 PIK41661.1 - 1.5e-12 47.7 16.5 2.3e-12 47.0 5.2 2.2 2 0 0 2 2 2 2 HYR domain EGF_3 PF12947.7 PIK41661.1 - 1.4 9.1 9.9 1.9 8.7 1.2 3.0 2 1 0 2 2 2 0 EGF domain DUF723 PF05265.13 PIK41661.1 - 2.3 8.2 7.7 1.1 9.2 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF723) Big_9 PF17963.1 PIK41661.1 - 4.1 8.2 12.6 0.52 11.1 3.2 2.2 1 1 1 2 2 2 0 Bacterial Ig domain GIY-YIG PF01541.24 PIK41662.1 - 2.2e-05 24.6 0.1 0.00022 21.4 0.1 2.2 2 0 0 2 2 2 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK41663.1 - 7e-27 94.4 0.0 8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HYR PF02494.16 PIK41664.1 - 2.8e-08 34.0 4.8 0.00039 20.7 0.5 2.4 2 0 0 2 2 2 2 HYR domain PNMA PF14893.6 PIK41665.1 - 0.00011 21.8 0.0 0.00026 20.5 0.0 1.6 1 1 0 1 1 1 1 PNMA zf-CCHC PF00098.23 PIK41665.1 - 0.00026 20.9 2.6 0.00026 20.9 2.6 1.9 2 0 0 2 2 2 1 Zinc knuckle Folliculin PF11704.8 PIK41665.1 - 0.089 12.7 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport PCSK9_C2 PF18464.1 PIK41665.1 - 0.21 11.6 0.2 0.21 11.6 0.2 1.9 2 0 0 2 2 2 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain zf-CCHC_2 PF13696.6 PIK41665.1 - 0.48 10.3 3.3 0.9 9.4 3.3 1.4 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 PIK41666.1 - 6.1e-17 61.9 0.1 3.2e-16 59.5 0.0 1.8 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK41667.1 - 3.1e-22 78.5 0.0 5.3e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK41667.1 - 2.6e-07 30.8 0.0 4.7e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK41667.1 - 0.006 16.8 0.0 0.02 15.1 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DUF2577 PF10844.8 PIK41667.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2577) Methyltransf_11 PF08241.12 PIK41668.1 - 2e-21 76.4 0.0 2.6e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK41668.1 - 1e-18 67.8 0.0 1.3e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK41668.1 - 2.8e-13 49.9 0.0 3.2e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK41668.1 - 4.8e-12 46.5 0.0 6.6e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK41668.1 - 6.8e-10 38.7 0.0 7.8e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK41668.1 - 3.3e-06 27.0 0.0 4e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 PIK41668.1 - 0.00024 21.0 0.0 0.00081 19.3 0.0 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 PIK41668.1 - 0.00051 18.7 0.0 0.00073 18.2 0.0 1.3 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase NodS PF05401.11 PIK41668.1 - 0.0013 18.4 0.0 0.0015 18.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 PIK41668.1 - 0.0096 15.5 0.0 0.014 15.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 PIK41668.1 - 0.023 14.7 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 PIK41668.1 - 0.026 14.3 0.0 0.52 10.0 0.1 2.0 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 PIK41668.1 - 0.029 14.5 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase TPMT PF05724.11 PIK41668.1 - 0.053 13.2 0.0 0.068 12.8 0.0 1.3 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) ADH_zinc_N PF00107.26 PIK41668.1 - 0.1 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RT_RNaseH PF17917.1 PIK41669.1 - 1.4e-31 108.9 0.1 3e-31 107.8 0.1 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41669.1 - 6.6e-30 103.1 0.0 1.5e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41669.1 - 0.018 14.6 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK41670.1 - 2.4e-19 69.7 0.0 3.7e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41670.1 - 0.0023 18.0 0.3 0.0061 16.6 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK41670.1 - 0.0024 17.6 0.3 0.012 15.3 0.0 2.2 2 1 0 2 2 2 1 Integrase core domain Phage_cap_E PF03864.15 PIK41670.1 - 0.081 12.1 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein E DUF3127 PF11325.8 PIK41670.1 - 0.13 12.6 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) Fibrinogen_C PF00147.18 PIK41673.1 - 1.6e-45 155.6 3.4 1.9e-45 155.3 3.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK41673.1 - 0.0061 15.9 0.2 0.0068 15.7 0.2 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Phosphodiest PF01663.22 PIK41675.1 - 1.3e-43 150.0 0.1 1.6e-43 149.7 0.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Endonuclease_NS PF01223.23 PIK41676.1 - 4.6e-09 36.4 0.0 6.5e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Pkinase PF00069.25 PIK41678.1 - 2.8e-56 190.8 0.0 4e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK41678.1 - 6.8e-19 68.2 0.0 8.6e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK41678.1 - 6.6e-09 35.5 0.0 9.2e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK41678.1 - 9.7e-09 34.9 0.0 1.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK41678.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 PIK41678.1 - 0.043 13.7 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 PIK41678.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 PIK41678.1 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Dynamin_M PF01031.20 PIK41679.1 - 2.4e-102 342.0 0.0 6.3e-102 340.6 0.0 1.6 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 PIK41679.1 - 1.9e-52 177.7 0.1 3.4e-52 176.9 0.1 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK41679.1 - 1.5e-05 25.1 0.2 5.7e-05 23.2 0.2 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK41679.1 - 0.019 15.4 0.0 0.081 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 PIK41679.1 - 0.022 14.1 0.1 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.6 PIK41679.1 - 0.076 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 PIK41680.1 - 1.1e-26 90.6 23.8 8e-05 22.4 0.1 9.0 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 PIK41680.1 - 3.9e-11 43.0 12.7 0.002 18.5 0.6 5.6 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK41680.1 - 9e-07 28.6 3.3 7.2 7.6 0.4 7.6 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 PIK41680.1 - 0.0023 17.7 21.2 1.9 8.3 3.3 6.5 2 2 3 5 5 5 3 Leucine rich repeat Nucleo_P87 PF07267.11 PIK41680.1 - 0.097 11.5 4.0 0.17 10.8 4.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Gal-3-0_sulfotr PF06990.11 PIK41681.1 - 7.6e-65 219.3 4.5 1e-63 215.7 2.0 2.0 1 1 1 2 2 2 2 Galactose-3-O-sulfotransferase COMM_domain PF07258.14 PIK41682.1 - 1.1e-18 67.1 0.0 2.2e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 COMM domain BAR_3 PF16746.5 PIK41682.1 - 0.024 14.3 0.3 3 7.5 0.0 2.2 2 0 0 2 2 2 0 BAR domain of APPL family JHD PF17811.1 PIK41683.1 - 6.8e-28 97.3 0.9 1.5e-27 96.2 0.9 1.6 1 0 0 1 1 1 1 Jumonji helical domain DUF5093 PF17011.5 PIK41683.1 - 1 9.6 4.2 0.22 11.8 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) PHD PF00628.29 PIK41684.1 - 7.9e-11 41.7 11.0 1.4e-10 40.9 11.0 1.4 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.6 PIK41684.1 - 9.5e-06 25.5 0.1 1.1e-05 25.3 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 PIK41684.1 - 2e-05 24.9 0.1 5.2e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD_4 PF16866.5 PIK41684.1 - 0.21 11.7 7.3 0.41 10.8 7.3 1.5 1 0 0 1 1 1 0 PHD-finger F5_F8_type_C PF00754.25 PIK41685.1 - 4.3e-07 30.1 0.0 2.9e-06 27.4 0.0 2.5 1 1 0 1 1 1 1 F5/8 type C domain SNF PF00209.18 PIK41687.1 - 6.1e-220 731.3 39.6 7.2e-220 731.1 39.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family STE2 PF02116.15 PIK41687.1 - 0.86 8.9 10.4 0.069 12.5 4.7 2.1 2 0 0 2 2 2 0 Fungal pheromone mating factor STE2 GPCR Gate PF07670.14 PIK41687.1 - 4.8 7.5 8.6 0.4 11.0 0.2 3.2 3 1 0 3 3 3 0 Nucleoside recognition PI-PLC-X PF00388.19 PIK41688.1 - 7.6e-60 200.7 0.1 1.4e-59 199.8 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 PIK41688.1 - 4.5e-38 130.1 0.2 1.3e-37 128.7 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 PIK41688.1 - 1.1e-16 61.1 0.2 3e-16 59.7 0.2 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 PIK41688.1 - 2.8e-14 53.2 0.0 7.5e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_10 PF14788.6 PIK41688.1 - 8.3e-08 32.0 0.9 2.4e-07 30.5 0.9 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 PIK41688.1 - 0.0017 18.8 2.3 0.017 15.6 0.5 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK41688.1 - 0.88 9.5 2.9 0.54 10.2 0.5 2.1 2 0 0 2 2 2 0 EF-hand domain pair Band_7 PF01145.25 PIK41689.1 - 7.1e-14 52.2 11.6 1.5e-07 31.6 11.5 2.5 2 1 0 2 2 2 2 SPFH domain / Band 7 family Med2 PF11214.8 PIK41689.1 - 0.0021 18.2 1.3 0.0021 18.2 1.3 1.6 2 0 0 2 2 2 1 Mediator complex subunit 2 Death PF00531.22 PIK41690.1 - 4.1e-13 49.3 1.1 5.8e-13 48.8 1.1 1.2 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK41691.1 - 1.4e-14 54.2 0.0 2.9e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain RVT_1 PF00078.27 PIK41692.1 - 7.2e-33 114.0 0.2 1.2e-32 113.3 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2452 PF10504.9 PIK41693.1 - 1.3e-61 206.6 0.1 1.7e-61 206.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) COX8 PF02285.15 PIK41693.1 - 0.031 14.2 0.4 0.078 12.9 0.0 1.8 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII DUF2721 PF11026.8 PIK41693.1 - 0.049 13.5 0.1 0.097 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) SDF PF00375.18 PIK41694.1 - 5.4e-96 322.0 13.2 6.5e-96 321.7 13.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family YfzA PF14118.6 PIK41694.1 - 0.16 12.4 1.7 0.5 10.8 1.7 1.9 1 0 0 1 1 1 0 YfzA-like protein DUF2062 PF09835.9 PIK41694.1 - 1.6 8.6 8.3 4.7 7.1 8.3 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) GDC-P PF02347.16 PIK41695.1 - 3.9e-51 174.3 0.0 4.4e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein PriA_C PF18074.1 PIK41696.1 - 0.52 11.2 4.2 2.2 9.1 0.4 2.7 1 1 1 2 2 2 0 Primosomal protein N C-terminal domain PCI PF01399.27 PIK41696.1 - 1.4 9.5 6.5 86 3.7 3.9 4.1 3 2 1 4 4 4 0 PCI domain Glyco_transf_49 PF13896.6 PIK41698.1 - 1.5e-47 162.6 1.4 2.5e-47 161.8 1.4 1.4 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 PIK41698.1 - 1.8e-17 63.8 0.9 4.3e-17 62.5 0.9 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 PIK41698.1 - 2e-05 24.2 2.5 3.5e-05 23.4 2.5 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Nucleotid_trans PF03407.16 PIK41698.1 - 0.018 15.0 0.2 2 8.3 0.3 2.5 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase TssO PF17561.2 PIK41698.1 - 0.055 13.6 1.2 0.14 12.3 1.2 1.6 1 0 0 1 1 1 0 Type VI secretion system, TssO bZIP_1 PF00170.21 PIK41698.1 - 0.29 11.2 8.4 0.047 13.8 3.8 2.0 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 PIK41698.1 - 0.34 11.0 3.0 0.84 9.8 3.0 1.7 1 0 0 1 1 1 0 Basic region leucine zipper Csm1_N PF18504.1 PIK41698.1 - 1 9.7 4.4 0.43 11.0 1.3 2.0 2 0 0 2 2 2 0 Csm1 N-terminal domain Ldl_recept_a PF00057.18 PIK41699.1 - 4e-08 33.3 9.3 8.9e-08 32.2 9.3 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK41699.1 - 0.00016 22.0 0.1 0.13 12.6 0.0 2.4 2 0 0 2 2 2 2 CUB domain Shisa PF13908.6 PIK41699.1 - 0.002 18.4 1.0 0.003 17.9 1.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM52 PF14979.6 PIK41699.1 - 0.064 13.2 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Transmembrane 52 Comm PF15957.5 PIK41699.1 - 0.44 10.9 5.1 1.1 9.7 5.1 1.6 1 1 0 1 1 1 0 Commissureless ANF_receptor PF01094.28 PIK41700.1 - 2.8e-22 79.3 0.1 2.9e-22 79.2 0.1 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK41700.1 - 0.00016 21.5 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ACT_7 PF13840.6 PIK41700.1 - 0.015 15.1 0.0 0.055 13.3 0.0 1.9 2 0 0 2 2 2 0 ACT domain Ldl_recept_b PF00058.17 PIK41701.1 - 1.8e-63 210.8 27.7 1.1e-10 41.8 0.1 12.8 13 0 0 13 13 13 10 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK41701.1 - 4.3e-18 65.3 23.3 1.5e-10 41.1 8.0 2.6 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK41701.1 - 4.8e-15 55.8 0.0 0.018 14.6 0.0 6.1 3 1 2 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 PIK41701.1 - 8.4e-10 38.3 0.0 2.9e-05 23.5 0.0 3.1 2 1 0 2 2 2 2 Domain of unknown function (DUF5050) Arylesterase PF01731.20 PIK41701.1 - 0.025 14.8 0.0 28 5.0 0.0 5.0 4 2 1 5 5 5 0 Arylesterase Ldl_recept_a PF00057.18 PIK41702.1 - 1.9e-11 44.0 5.8 1.9e-11 44.0 5.8 2.2 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK41702.1 - 6.4e-08 33.0 4.4 0.0016 18.9 0.0 5.1 5 0 0 5 5 5 2 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK41702.1 - 1.1e-07 32.0 6.7 1.1e-07 32.0 6.7 2.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site SCRG1 PF15224.6 PIK41702.1 - 0.071 13.2 1.8 0.14 12.3 0.3 2.2 3 0 0 3 3 3 0 Scrapie-responsive protein 1 PHD PF00628.29 PIK41703.1 - 6.8e-10 38.7 8.5 1.2e-09 37.9 8.5 1.4 1 0 0 1 1 1 1 PHD-finger Metal_resist PF13801.6 PIK41703.1 - 0.0091 16.2 2.0 0.02 15.1 2.0 1.5 1 0 0 1 1 1 1 Heavy-metal resistance APG6_N PF17675.1 PIK41703.1 - 0.015 15.8 8.5 0.015 15.8 8.5 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region BLOC1_2 PF10046.9 PIK41703.1 - 0.039 14.2 0.9 0.039 14.2 0.9 2.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PHD_2 PF13831.6 PIK41703.1 - 0.046 13.3 3.8 0.14 11.7 3.8 1.9 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.16 PIK41703.1 - 0.047 14.0 3.6 0.047 14.0 3.6 1.9 2 0 0 2 2 2 0 C1 domain zf-RING_2 PF13639.6 PIK41703.1 - 0.57 10.6 11.1 0.94 9.9 11.1 1.4 1 0 0 1 1 1 0 Ring finger domain MCU PF04678.13 PIK41703.1 - 0.74 9.9 4.5 0.2 11.7 0.4 2.1 2 1 0 2 2 2 0 Mitochondrial calcium uniporter Helicase_RecD PF05127.14 PIK41705.1 - 9.9e-64 214.4 0.0 4.9e-63 212.2 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 PIK41705.1 - 9.4e-26 89.6 0.0 1.8e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 PIK41705.1 - 0.00016 21.5 0.0 0.028 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain DEAD PF00270.29 PIK41705.1 - 0.00028 20.7 0.0 0.00058 19.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK41705.1 - 0.00033 21.0 0.0 0.1 12.9 0.0 2.9 2 1 0 2 2 2 2 AAA domain LepB_GAP_N PF18172.1 PIK41705.1 - 0.024 14.5 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 LepB GAP domain N-terminal subdomain GNAT_acetyltr_2 PF13718.6 PIK41706.1 - 3.4e-102 340.7 0.2 6.1e-100 333.3 0.0 2.2 2 0 0 2 2 2 2 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 PIK41706.1 - 1.6e-71 240.8 7.5 2.5e-71 240.1 7.5 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_1 PF00583.25 PIK41706.1 - 0.0024 18.1 0.0 0.006 16.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK41706.1 - 0.0037 17.7 0.0 0.01 16.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FlgT_M PF16539.5 PIK41706.1 - 0.18 12.0 1.4 0.44 10.7 1.4 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Fes1 PF08609.10 PIK41707.1 - 1.1e-05 26.3 2.0 1.1e-05 26.3 2.0 2.8 3 1 0 3 3 3 1 Nucleotide exchange factor Fes1 V-ATPase_H_C PF11698.8 PIK41707.1 - 0.042 14.0 5.1 0.52 10.4 0.1 3.7 2 1 2 4 4 4 0 V-ATPase subunit H HEAT_2 PF13646.6 PIK41707.1 - 0.057 13.8 0.1 0.43 11.0 0.1 2.4 2 1 0 2 2 2 0 HEAT repeats WGG PF10273.9 PIK41707.1 - 0.067 13.9 1.9 3.5 8.3 1.7 3.3 2 1 0 2 2 2 0 Pre-rRNA-processing protein TSR2 DUF4404 PF14357.6 PIK41707.1 - 0.13 12.9 2.3 0.19 12.4 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) HEAT PF02985.22 PIK41707.1 - 0.22 11.9 0.6 2.3 8.7 0.0 3.0 5 0 0 5 5 5 0 HEAT repeat PAS_11 PF14598.6 PIK41708.1 - 6.4e-25 87.5 0.1 3.4e-21 75.5 0.0 3.0 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 PIK41708.1 - 1.3e-18 67.1 0.0 1e-13 51.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 PIK41708.1 - 3.4e-15 55.7 1.4 7.2e-15 54.7 1.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.25 PIK41708.1 - 1.4e-13 50.8 0.0 2.7e-05 24.1 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK41708.1 - 1.1e-08 35.2 0.0 0.0021 18.3 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 PIK41708.1 - 0.0096 16.2 0.0 3.7 7.8 0.0 2.6 2 1 0 2 2 2 2 PAS fold PAS_2 PF08446.11 PIK41708.1 - 0.11 13.2 0.0 0.38 11.4 0.0 1.9 2 0 0 2 2 2 0 PAS fold Gal-3-0_sulfotr PF06990.11 PIK41709.1 - 1.9e-50 171.9 1.2 2.5e-50 171.6 1.2 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase ComGF PF15980.5 PIK41709.1 - 0.09 13.2 2.9 9.8 6.6 0.6 2.5 2 0 0 2 2 2 0 Putative Competence protein ComGF V-set PF07686.17 PIK41710.1 - 1e-05 25.7 0.9 1e-05 25.7 0.9 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41710.1 - 0.00011 22.8 7.7 0.0025 18.4 1.4 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK41710.1 - 0.0065 16.5 0.4 0.019 15.0 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Adeno_E3_CR1 PF02440.15 PIK41710.1 - 0.0092 15.7 1.8 0.0092 15.7 1.8 2.1 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 Glyco_hydro_42M PF08532.10 PIK41710.1 - 0.024 14.1 0.0 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain A2M PF00207.22 PIK41710.1 - 0.079 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin family Ig_4 PF16680.5 PIK41710.1 - 1.2 9.4 5.0 9.2 6.6 2.3 3.2 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain ig PF00047.25 PIK41710.1 - 1.4 9.1 14.5 0.23 11.6 3.8 3.8 4 1 0 4 4 4 0 Immunoglobulin domain Glyco_hydro_35 PF01301.19 PIK41711.1 - 6.4e-116 387.4 0.6 8e-116 387.1 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 PIK41711.1 - 2e-14 53.7 0.1 3.1e-13 49.8 0.0 2.5 1 1 1 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 PIK41711.1 - 3.4e-06 27.6 0.3 0.2 12.3 0.0 3.3 3 1 0 3 3 3 2 Beta-galactosidase jelly roll domain Cellulase PF00150.18 PIK41711.1 - 0.067 12.6 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Asp PF00026.23 PIK41712.1 - 5.4e-26 91.8 0.3 3.2e-19 69.5 0.1 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 PIK41712.1 - 9.5e-08 32.5 0.0 9.3e-05 22.7 0.0 2.1 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Pterin_4a PF01329.19 PIK41713.1 - 2e-28 98.4 0.0 2.6e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase HTH_ParB PF17762.1 PIK41713.1 - 0.19 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 HTH domain found in ParB protein Glyco_transf_29 PF00777.18 PIK41714.1 - 1.2e-21 77.3 0.1 1.3e-21 77.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RVT_1 PF00078.27 PIK41716.1 - 6.4e-13 48.7 0.1 1.5e-12 47.5 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TMEM154 PF15102.6 PIK41717.1 - 5.8e-08 32.8 2.1 1.1e-07 31.8 2.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family Rax2 PF12768.7 PIK41717.1 - 0.0001 21.8 0.1 0.00018 21.1 0.1 1.4 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Ig_3 PF13927.6 PIK41717.1 - 0.00022 21.7 4.6 0.03 14.9 0.0 3.3 4 1 0 4 4 2 1 Immunoglobulin domain Podoplanin PF05808.11 PIK41717.1 - 0.0015 18.6 1.0 0.0029 17.7 1.0 1.5 1 0 0 1 1 1 1 Podoplanin Ig_2 PF13895.6 PIK41717.1 - 0.0022 18.3 2.8 0.22 11.9 0.1 3.0 1 1 1 2 2 2 1 Immunoglobulin domain DUF1180 PF06679.12 PIK41717.1 - 0.0051 17.2 2.3 0.012 16.1 2.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1180) DUF5305 PF17231.2 PIK41717.1 - 0.0059 16.0 1.2 0.0059 16.0 1.2 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5305) 7TM_GPCR_Srv PF10323.9 PIK41717.1 - 0.006 16.0 0.4 0.013 14.9 0.4 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv RIFIN PF02009.16 PIK41717.1 - 0.0066 16.4 0.3 0.0091 15.9 0.3 1.2 1 0 0 1 1 1 1 Rifin I-set PF07679.16 PIK41717.1 - 0.0079 16.2 0.1 0.027 14.5 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain DUF4064 PF13273.6 PIK41717.1 - 0.0094 16.2 0.3 0.023 15.0 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) Amnionless PF14828.6 PIK41717.1 - 0.01 14.7 0.1 0.015 14.1 0.1 1.2 1 0 0 1 1 1 1 Amnionless DUF5385 PF17359.2 PIK41717.1 - 0.011 15.4 0.1 0.018 14.6 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) EphA2_TM PF14575.6 PIK41717.1 - 0.011 16.6 0.1 0.011 16.6 0.1 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 PIK41717.1 - 0.012 15.9 0.1 0.012 15.9 0.1 2.1 2 0 0 2 2 1 0 Orf78 (ac78) FAM163 PF15069.6 PIK41717.1 - 0.015 15.8 0.0 0.13 12.7 0.0 2.3 2 0 0 2 2 2 0 FAM163 family ig PF00047.25 PIK41717.1 - 0.019 15.1 6.0 0.77 10.0 0.1 3.1 3 1 0 3 3 2 0 Immunoglobulin domain Insulin_TMD PF17870.1 PIK41717.1 - 0.022 14.8 1.3 0.022 14.8 1.3 1.9 2 0 0 2 2 1 0 Insulin receptor trans-membrane segment EVI2A PF05399.11 PIK41717.1 - 0.023 14.3 1.1 0.044 13.4 1.1 1.5 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Peptidase_M56 PF05569.11 PIK41717.1 - 0.033 13.4 0.2 0.055 12.6 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 Chordopox_A13L PF05961.11 PIK41717.1 - 0.044 14.0 2.0 0.048 13.9 0.1 2.1 2 0 0 2 2 1 0 Chordopoxvirus A13L protein DUF4690 PF15756.5 PIK41717.1 - 0.066 13.8 1.5 0.21 12.2 1.5 1.8 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF4711 PF15829.5 PIK41717.1 - 0.079 12.9 3.3 0.14 12.1 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Baculo_11_kDa PF06143.11 PIK41717.1 - 0.08 12.5 0.4 0.08 12.5 0.4 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family Stevor PF17410.2 PIK41717.1 - 0.087 12.4 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame SIT PF15330.6 PIK41717.1 - 0.094 13.2 0.1 8 6.9 0.0 2.7 3 0 0 3 3 2 0 SHP2-interacting transmembrane adaptor protein, SIT Shisa PF13908.6 PIK41717.1 - 0.098 12.9 5.4 0.16 12.2 4.2 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Cation_ATPase_C PF00689.21 PIK41717.1 - 0.23 11.1 0.1 0.23 11.1 0.1 1.7 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus Vpu PF00558.19 PIK41717.1 - 0.94 9.3 2.6 0.57 10.0 0.5 1.7 2 0 0 2 2 1 0 Vpu protein DUF3377 PF11857.8 PIK41717.1 - 1.1 9.2 5.3 0.11 12.4 0.5 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) DUF515 PF04415.12 PIK41717.1 - 2.6 6.4 13.1 0.023 13.1 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF515) Pyr_redox_2 PF07992.14 PIK41718.1 - 2.4e-16 59.9 1.9 2e-15 56.8 1.9 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK41718.1 - 1.9e-14 54.0 1.6 3.4e-11 43.5 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 PIK41718.1 - 7.3e-05 23.2 1.8 0.26 11.8 0.1 2.2 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 PIK41718.1 - 0.0002 21.5 0.4 0.52 10.6 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 PIK41718.1 - 0.00022 20.5 1.9 0.0049 16.1 0.1 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 PIK41718.1 - 0.00039 20.1 1.9 0.36 10.3 0.5 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 PIK41718.1 - 0.00099 18.5 3.4 0.32 10.3 0.2 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 PIK41718.1 - 0.002 18.4 1.4 0.44 10.8 0.1 2.4 2 0 0 2 2 2 2 TrkA-N domain Pyr_redox_3 PF13738.6 PIK41718.1 - 0.003 16.9 0.1 0.46 9.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 PIK41718.1 - 0.019 14.1 1.9 0.022 13.9 0.0 1.9 2 1 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 PIK41718.1 - 0.023 13.6 1.4 1.7 7.4 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.14 PIK41718.1 - 0.071 12.7 1.8 1.2 8.6 0.1 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Semialdhyde_dh PF01118.24 PIK41718.1 - 0.088 13.2 1.4 5.6 7.4 0.1 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain HI0933_like PF03486.14 PIK41718.1 - 0.12 11.1 2.2 0.49 9.1 0.3 2.1 2 0 0 2 2 2 0 HI0933-like protein Peptidase_S28 PF05577.12 PIK41718.1 - 0.18 10.5 0.3 7.1 5.3 0.0 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase S28 GIDA PF01134.22 PIK41718.1 - 0.25 10.4 2.1 3 6.8 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A ThiF PF00899.21 PIK41718.1 - 0.53 9.6 2.0 11 5.3 0.0 2.2 2 0 0 2 2 2 0 ThiF family hDGE_amylase PF14701.6 PIK41719.1 - 8.9e-06 25.0 0.0 9e-06 25.0 0.0 1.0 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain EF-hand_1 PF00036.32 PIK41720.1 - 5.5e-20 69.4 9.6 3.1e-06 26.3 0.0 5.4 6 0 0 6 6 6 3 EF hand EF-hand_7 PF13499.6 PIK41720.1 - 6.2e-19 68.2 4.3 9.3e-13 48.4 0.3 3.6 4 0 0 4 4 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK41720.1 - 3.4e-16 57.7 5.4 4.5e-06 26.2 0.0 5.8 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 PIK41720.1 - 3.8e-15 54.6 6.5 5e-07 28.9 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK41720.1 - 8.7e-13 47.9 10.8 5.5e-11 42.1 0.3 3.9 3 1 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK41720.1 - 2.2e-05 24.7 3.0 0.00027 21.2 0.1 3.3 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK41720.1 - 0.0001 22.2 1.6 0.055 13.4 0.0 3.3 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF_assoc_2 PF08356.12 PIK41720.1 - 0.00016 21.6 0.0 0.00056 19.8 0.0 1.9 1 0 0 1 1 1 1 EF hand associated EFhand_Ca_insen PF08726.10 PIK41720.1 - 0.00077 19.5 0.0 0.0019 18.2 0.0 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_9 PF14658.6 PIK41720.1 - 0.06 13.7 0.1 0.58 10.5 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 PIK41720.1 - 0.078 13.2 0.3 1.6 8.9 0.0 2.6 1 1 1 2 2 2 0 Dockerin type I domain RNB PF00773.19 PIK41720.1 - 0.31 10.3 7.0 0.32 10.3 3.8 2.1 1 1 1 2 2 2 0 RNB domain BSMAP PF12280.8 PIK41721.1 - 0.039 14.1 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 Brain specific membrane anchored protein Mak10 PF04112.13 PIK41722.1 - 1.3e-24 86.6 0.1 2e-24 86.0 0.1 1.3 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PDZ PF00595.24 PIK41724.1 - 4.2e-42 142.4 5.5 3.5e-14 52.9 0.5 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK41724.1 - 2.6e-17 62.4 0.2 8.9e-09 35.1 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK41724.1 - 4.3e-12 46.2 1.4 0.0022 18.3 0.3 3.4 3 0 0 3 3 3 3 PDZ domain PT-HINT PF07591.11 PIK41724.1 - 0.071 13.4 0.0 12 6.2 0.0 2.4 2 0 0 2 2 2 0 Pretoxin HINT domain SR-25 PF10500.9 PIK41726.1 - 2.9e-07 30.4 36.5 3.7e-07 30.0 36.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Peroxin-3 PF04882.12 PIK41726.1 - 0.059 12.4 6.0 0.06 12.3 6.0 1.0 1 0 0 1 1 1 0 Peroxin-3 MDFI PF15316.6 PIK41726.1 - 0.16 12.0 7.7 0.24 11.4 7.7 1.3 1 0 0 1 1 1 0 MyoD family inhibitor Herpes_capsid PF06112.11 PIK41726.1 - 0.43 10.6 15.0 0.97 9.5 15.0 1.6 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein AF-4 PF05110.13 PIK41726.1 - 0.57 8.2 23.3 0.79 7.7 23.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCDC106 PF15794.5 PIK41726.1 - 0.8 9.4 24.0 1.1 9.0 24.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SUZ PF12752.7 PIK41726.1 - 3.6 8.4 13.5 7 7.5 13.5 1.5 1 0 0 1 1 1 0 SUZ domain Herpes_pp85 PF04637.12 PIK41726.1 - 9.9 4.4 9.3 13 4.1 9.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) M16C_assoc PF08367.11 PIK41727.1 - 6.5e-75 251.5 0.2 1.1e-74 250.7 0.2 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 PIK41727.1 - 1.3e-29 103.5 0.0 1.4e-19 70.9 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 PIK41727.1 - 5.3e-12 46.0 0.1 4.4e-09 36.5 0.0 3.6 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) DUF1743 PF08489.11 PIK41727.1 - 0.045 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) BLI1 PF17324.2 PIK41727.1 - 0.082 13.6 0.5 0.25 12.0 0.5 1.8 1 0 0 1 1 1 0 BLOC-1 interactor 1 ATPgrasp_YheCD PF14398.6 PIK41727.1 - 0.17 11.1 0.6 0.3 10.3 0.6 1.3 1 0 0 1 1 1 0 YheC/D like ATP-grasp RTX_C PF08339.10 PIK41727.1 - 0.49 10.4 2.0 0.54 10.3 0.3 1.9 2 0 0 2 2 2 0 RTX C-terminal domain TSP_1 PF00090.19 PIK41728.1 - 7.1e-14 51.8 50.0 1.3e-07 31.7 4.0 6.2 7 0 0 7 7 7 4 Thrombospondin type 1 domain Ras PF00071.22 PIK41729.1 - 2.7e-21 75.8 0.2 3.3e-21 75.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 PIK41729.1 - 0.00053 19.5 0.0 0.00063 19.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK41729.1 - 0.00092 18.8 0.1 0.0011 18.6 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK41729.1 - 0.029 14.3 0.0 0.13 12.2 0.0 1.8 1 1 1 2 2 2 0 RsgA GTPase DUF2325 PF10087.9 PIK41729.1 - 0.032 14.4 0.2 0.13 12.3 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) Roc PF08477.13 PIK41729.1 - 0.079 13.2 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SAPS PF04499.15 PIK41730.1 - 1.8e-87 294.2 8.5 3.5e-56 191.0 1.9 5.0 3 2 1 4 4 4 3 SIT4 phosphatase-associated protein FAM60A PF15396.6 PIK41731.1 - 1.9e-73 246.9 7.4 3.4e-73 246.2 7.4 1.4 1 0 0 1 1 1 1 Protein Family FAM60A zf-AD PF07776.15 PIK41731.1 - 0.26 11.5 7.0 0.33 11.2 1.5 3.2 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) bZIP_1 PF00170.21 PIK41733.1 - 5e-07 29.7 16.1 5e-07 29.7 16.1 1.9 2 0 0 2 2 1 1 bZIP transcription factor OmpH PF03938.14 PIK41733.1 - 0.0019 18.6 4.7 0.0034 17.7 4.7 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) HAUS-augmin3 PF14932.6 PIK41733.1 - 0.0019 17.8 1.9 0.0028 17.3 1.9 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF3450 PF11932.8 PIK41733.1 - 0.0055 16.0 1.5 0.0088 15.4 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 PIK41733.1 - 0.0056 16.7 11.0 0.0097 16.0 11.0 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 PIK41733.1 - 0.006 17.1 8.1 0.006 17.1 8.1 1.7 2 0 0 2 2 1 1 Apg6 coiled-coil region IFT57 PF10498.9 PIK41733.1 - 0.0066 15.5 7.1 0.01 14.9 7.1 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Fmp27_WPPW PF10359.9 PIK41733.1 - 0.0081 15.1 2.6 0.011 14.6 2.6 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Spc7 PF08317.11 PIK41733.1 - 0.0089 14.9 8.4 0.013 14.4 8.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein FTA4 PF13093.6 PIK41733.1 - 0.012 15.6 3.2 0.02 14.8 3.2 1.4 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Syntaxin-6_N PF09177.11 PIK41733.1 - 0.013 16.0 2.8 0.025 15.1 2.8 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal ADIP PF11559.8 PIK41733.1 - 0.015 15.4 8.1 0.026 14.6 8.1 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Rab5-bind PF09311.11 PIK41733.1 - 0.016 14.6 4.1 0.025 14.0 4.1 1.2 1 0 0 1 1 1 0 Rabaptin-like protein STAT_alpha PF01017.20 PIK41733.1 - 0.017 15.0 2.4 0.04 13.8 2.4 1.6 1 0 0 1 1 1 0 STAT protein, all-alpha domain LMBR1 PF04791.16 PIK41733.1 - 0.022 13.7 0.3 0.027 13.4 0.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 PIK41733.1 - 0.023 14.3 1.1 0.031 13.8 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc29 PF17082.5 PIK41733.1 - 0.025 14.4 0.8 0.04 13.8 0.8 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 bZIP_Maf PF03131.17 PIK41733.1 - 0.027 15.0 8.2 0.052 14.1 8.2 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor MbeD_MobD PF04899.12 PIK41733.1 - 0.03 14.4 0.7 0.056 13.6 0.7 1.5 1 0 0 1 1 1 0 MbeD/MobD like Prominin PF05478.11 PIK41733.1 - 0.035 12.1 1.3 0.047 11.7 1.3 1.1 1 0 0 1 1 1 0 Prominin ZapB PF06005.12 PIK41733.1 - 0.036 14.5 4.2 0.036 14.5 4.2 2.5 3 0 0 3 3 2 0 Cell division protein ZapB Phage_GPO PF05929.11 PIK41733.1 - 0.037 13.6 1.4 0.053 13.1 1.4 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Sec34 PF04136.15 PIK41733.1 - 0.042 13.7 0.8 0.073 12.9 0.8 1.3 1 0 0 1 1 1 0 Sec34-like family DUF1759 PF03564.15 PIK41733.1 - 0.072 13.0 1.2 0.18 11.8 1.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) AAA_13 PF13166.6 PIK41733.1 - 0.073 11.7 4.5 0.1 11.2 4.5 1.1 1 0 0 1 1 1 0 AAA domain Vps53_N PF04100.12 PIK41733.1 - 0.076 12.0 2.2 0.11 11.5 2.2 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal CDPS PF16715.5 PIK41733.1 - 0.08 12.6 0.2 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 Cyclodipeptide synthase DUF3552 PF12072.8 PIK41733.1 - 0.098 12.1 10.7 0.15 11.5 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF1690 PF07956.11 PIK41733.1 - 0.099 13.1 7.2 0.17 12.3 7.2 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Baculo_PEP_C PF04513.12 PIK41733.1 - 0.11 12.6 0.3 0.21 11.7 0.3 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus FAP206 PF12018.8 PIK41733.1 - 0.12 11.9 2.6 0.29 10.6 2.6 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF1664 PF07889.12 PIK41733.1 - 0.13 12.3 2.7 0.22 11.6 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Tektin PF03148.14 PIK41733.1 - 0.15 10.8 7.4 0.21 10.3 7.4 1.1 1 0 0 1 1 1 0 Tektin family 3HCDH_N PF02737.18 PIK41733.1 - 0.22 11.4 1.7 0.33 10.8 1.7 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UPF0242 PF06785.11 PIK41733.1 - 0.22 11.6 6.8 0.37 10.9 6.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 PIK41733.1 - 0.24 11.7 5.6 0.78 10.1 5.3 1.7 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CC2-LZ PF16516.5 PIK41733.1 - 0.26 11.7 8.1 0.48 10.8 8.1 1.4 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FapA PF03961.13 PIK41733.1 - 0.27 9.8 5.4 0.38 9.3 5.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A GIT_CC PF16559.5 PIK41733.1 - 0.3 11.0 3.3 0.87 9.5 0.4 2.5 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor SHE3 PF17078.5 PIK41733.1 - 0.34 10.6 8.3 0.55 9.9 8.3 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF948 PF06103.11 PIK41733.1 - 0.35 11.2 1.1 0.64 10.3 1.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HemX PF04375.14 PIK41733.1 - 0.35 10.1 3.7 0.52 9.5 3.7 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase HIP1_clath_bdg PF16515.5 PIK41733.1 - 0.43 11.2 8.6 0.99 10.1 8.6 1.6 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fib_alpha PF08702.10 PIK41733.1 - 0.51 10.5 3.8 0.9 9.7 3.8 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 PIK41733.1 - 0.7 10.3 5.4 1.7 9.1 4.3 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Remorin_C PF03763.13 PIK41733.1 - 0.95 9.4 12.2 1.6 8.7 12.2 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region TMPIT PF07851.13 PIK41733.1 - 0.99 8.6 4.5 1.7 7.8 4.5 1.4 1 0 0 1 1 1 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 PIK41733.1 - 1.3 9.3 10.0 2.6 8.3 10.0 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain V_ATPase_I PF01496.19 PIK41733.1 - 2.1 6.2 4.1 2.7 5.8 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4404 PF14357.6 PIK41733.1 - 2.8 8.7 6.5 4.8 7.9 1.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Nnf1 PF03980.14 PIK41733.1 - 2.8 8.4 9.3 0.51 10.7 2.9 2.4 1 1 1 2 2 2 0 Nnf1 YabA PF06156.13 PIK41733.1 - 2.9 8.6 7.4 9.5 6.9 7.4 1.9 1 1 0 1 1 1 0 Initiation control protein YabA YtxH PF12732.7 PIK41733.1 - 4.3 7.9 5.6 7.5 7.2 5.6 1.4 1 0 0 1 1 1 0 YtxH-like protein YojJ PF10372.9 PIK41733.1 - 5.5 7.2 7.5 10 6.3 1.4 2.7 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF4337 PF14235.6 PIK41733.1 - 5.6 7.1 5.7 9.5 6.3 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Latarcin PF10279.9 PIK41733.1 - 9.8 6.7 8.7 33 5.0 8.5 1.9 1 1 0 1 1 1 0 Latarcin precursor Dynein_C PF18199.1 PIK41734.1 - 6.8e-118 393.3 0.0 1.2e-117 392.5 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 PIK41734.1 - 2.6e-60 203.3 1.8 1.2e-58 197.9 0.1 3.0 3 0 0 3 3 3 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK41734.1 - 3e-56 189.7 0.1 5.7e-56 188.8 0.1 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK41734.1 - 6.9e-46 155.2 0.0 3e-45 153.2 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 PIK41735.1 - 3.6e-107 357.5 1.6 6.5e-107 356.7 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 PIK41735.1 - 3.1e-36 124.6 0.0 8.2e-36 123.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 PIK41735.1 - 4.1e-22 78.3 0.0 4.1e-22 78.3 0.0 2.8 3 1 1 4 4 4 1 AAA+ lid domain MT PF12777.7 PIK41735.1 - 1.7e-06 27.3 10.9 2.7e-06 26.7 10.9 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 PIK41735.1 - 0.0036 17.3 0.1 0.94 9.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) NAD_binding_5 PF07994.12 PIK41735.1 - 0.0041 16.6 0.4 0.0041 16.6 0.4 1.8 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase ISG65-75 PF11727.8 PIK41735.1 - 0.11 11.7 6.9 0.2 10.9 6.9 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein AAA PF00004.29 PIK41735.1 - 0.52 10.7 3.4 0.93 9.9 0.0 3.1 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 PIK41736.1 - 2.9e-162 539.2 0.0 7.3e-161 534.6 0.0 2.5 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK41736.1 - 1.9e-148 494.8 2.8 1.9e-148 494.8 2.8 3.5 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_AAA_lid PF17852.1 PIK41736.1 - 1.1e-31 109.6 0.3 7.2e-31 106.9 0.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 PIK41736.1 - 1.6e-21 76.7 2.5 2e-16 60.0 0.2 3.6 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA_5 PF07728.14 PIK41736.1 - 2e-11 44.0 0.7 8.3e-06 25.8 0.0 4.8 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK41736.1 - 1.9e-06 28.2 0.6 0.85 9.9 0.1 3.9 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 PIK41736.1 - 2.5e-06 28.1 0.2 0.042 14.4 0.0 5.0 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 PIK41736.1 - 2e-05 25.0 1.5 0.92 9.9 0.0 4.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK41736.1 - 0.00011 22.7 0.1 4.8 7.5 0.0 3.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 PIK41736.1 - 0.00013 21.8 5.1 0.14 11.8 0.1 3.5 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 PIK41736.1 - 0.00038 19.6 2.2 0.055 12.5 0.1 2.8 3 0 0 3 3 3 2 Type II/IV secretion system protein Mg_chelatase PF01078.21 PIK41736.1 - 0.00097 18.6 2.8 0.0066 15.8 0.0 3.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK41736.1 - 0.0017 18.7 2.9 10 6.6 0.0 4.5 4 0 0 4 4 4 0 RNA helicase DEAD PF00270.29 PIK41736.1 - 0.0018 18.1 0.2 1.2 8.8 0.1 3.1 3 0 0 3 3 2 1 DEAD/DEAH box helicase AAA_33 PF13671.6 PIK41736.1 - 0.0082 16.3 3.0 3.3 7.9 0.1 4.1 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 PIK41736.1 - 0.0094 15.7 0.5 11 5.7 0.0 3.6 3 0 0 3 3 3 0 AAA domain DUF1885 PF08968.10 PIK41736.1 - 0.032 14.3 0.5 0.081 13.0 0.3 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF1885) DUF853 PF05872.12 PIK41736.1 - 0.035 12.7 2.8 1 7.8 0.0 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_19 PF13245.6 PIK41736.1 - 0.098 13.0 4.7 25 5.2 0.1 3.7 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 PIK41736.1 - 0.11 13.0 1.3 5.5 7.5 0.0 3.1 3 0 0 3 3 2 0 ABC transporter Sigma54_activat PF00158.26 PIK41736.1 - 0.11 12.2 1.0 2.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Cytochrom_B562 PF07361.11 PIK41736.1 - 0.34 11.6 2.2 8.1 7.2 1.2 3.5 3 0 0 3 3 3 0 Cytochrome b562 PhoH PF02562.16 PIK41736.1 - 0.79 9.1 10.8 0.92 8.9 0.0 3.9 5 0 0 5 5 4 0 PhoH-like protein AAA_25 PF13481.6 PIK41736.1 - 0.89 9.1 3.8 7.1 6.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 PIK41736.1 - 1.4 8.8 3.4 5.3 6.9 0.0 3.5 4 0 0 4 4 4 0 NACHT domain Rad17 PF03215.15 PIK41736.1 - 1.6 8.6 4.7 21 5.0 0.0 3.5 4 0 0 4 4 3 0 Rad17 P-loop domain TsaE PF02367.17 PIK41736.1 - 1.8 8.6 7.3 37 4.3 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 PIK41736.1 - 2.2 8.0 5.8 5.1 6.8 0.0 4.1 5 0 0 5 5 4 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 PIK41736.1 - 2.3 8.2 9.3 2.4 8.1 0.0 4.0 5 0 0 5 5 5 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 PIK41736.1 - 5.3 6.6 10.2 16 5.0 0.2 4.0 3 1 1 4 4 4 0 SRP54-type protein, GTPase domain DUF2634 PF10934.8 PIK41737.1 - 0.083 13.0 0.8 0.19 11.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2634) LysM PF01476.20 PIK41739.1 - 0.17 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 LysM domain SRA PF18491.1 PIK41740.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 SET and RING associated domain PspB PF06667.12 PIK41740.1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Phage shock protein B P2 PF07194.11 PIK41740.1 - 0.22 11.6 2.9 1.7 8.8 0.7 2.3 2 1 0 2 2 2 0 P2 response regulator binding domain Ubiquitin_2 PF14560.6 PIK41741.1 - 7.6e-06 26.3 0.0 0.14 12.6 0.0 2.8 2 0 0 2 2 2 2 Ubiquitin-like domain UCH PF00443.29 PIK41742.1 - 1.4e-31 109.9 0.8 1.8e-31 109.6 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK41742.1 - 1.3e-28 100.6 2.1 2.7e-28 99.5 2.1 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase N_formyltrans_C PF18216.1 PIK41742.1 - 0.016 14.9 0.1 0.057 13.1 0.1 2.0 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain HypA PF01155.19 PIK41742.1 - 0.21 11.6 1.1 0.51 10.4 1.1 1.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 PIK41742.1 - 1.4 8.6 7.1 3.2 7.4 2.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Sep15_SelM PF08806.11 PIK41743.1 - 1.8e-19 69.6 0.2 2e-19 69.5 0.2 1.0 1 0 0 1 1 1 1 Sep15/SelM redox domain Rubrerythrin PF02915.17 PIK41743.1 - 0.01 16.2 0.0 0.012 16.1 0.0 1.0 1 0 0 1 1 1 0 Rubrerythrin Kelch_1 PF01344.25 PIK41744.1 - 1.6e-52 174.8 9.7 3.4e-15 55.4 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 PIK41744.1 - 4.6e-26 90.2 0.9 3.1e-09 36.8 0.0 4.6 3 1 1 4 4 4 4 Kelch motif Kelch_2 PF07646.15 PIK41744.1 - 8.8e-20 69.9 0.6 1e-06 28.4 0.0 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 PIK41744.1 - 2.9e-18 65.7 0.1 3.9e-05 23.8 0.0 4.4 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK41744.1 - 8.2e-16 57.7 0.1 5.9e-05 23.0 0.0 4.4 3 1 1 4 4 4 3 Galactose oxidase, central domain BACK PF07707.15 PIK41744.1 - 1.5e-06 28.2 0.3 2.7e-06 27.4 0.3 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 PIK41744.1 - 4.6e-05 23.3 0.1 0.66 10.0 0.0 3.4 4 0 0 4 4 4 2 Kelch motif BILBO1_N PF18281.1 PIK41744.1 - 0.054 13.9 0.0 19 5.7 0.0 3.2 3 0 0 3 3 3 0 BILBO1 N-terminal domain BTB PF00651.31 PIK41745.1 - 2.9e-19 69.3 0.0 3.7e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain FAD_binding_7 PF03441.14 PIK41746.1 - 7.5e-61 205.1 0.3 1.1e-59 201.4 0.3 2.1 1 1 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 PIK41746.1 - 8.1e-46 156.0 0.0 1.4e-45 155.2 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase IU_nuc_hydro PF01156.19 PIK41747.1 - 2.9e-76 256.9 0.0 3.4e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase IU_nuc_hydro PF01156.19 PIK41748.1 - 2.5e-71 240.8 0.0 2.9e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase RVT_1 PF00078.27 PIK41749.1 - 7.4e-29 100.8 0.0 1.1e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK41749.1 - 0.0092 16.6 0.0 0.055 14.1 0.0 2.4 2 0 0 2 2 2 1 Aspartyl protease TPR_2 PF07719.17 PIK41751.1 - 4.9e-22 76.2 1.7 0.001 19.0 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41751.1 - 6.9e-20 70.0 4.5 6.4e-06 25.8 0.0 7.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 PIK41751.1 - 5.4e-12 45.8 11.0 0.00028 21.1 0.1 6.2 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK41751.1 - 8.8e-12 44.5 1.6 0.11 12.1 0.0 7.0 6 2 1 7 7 7 3 TPR repeat TPR_16 PF13432.6 PIK41751.1 - 1.3e-10 41.8 0.9 0.3 11.8 0.0 5.5 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK41751.1 - 2.9e-08 33.3 0.0 0.69 10.3 0.0 6.5 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK41751.1 - 3e-06 27.6 7.1 84 4.4 0.1 8.2 4 2 4 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK41751.1 - 1e-05 25.5 7.6 0.14 12.3 0.1 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK41751.1 - 2.7e-05 24.6 6.3 21 5.7 0.0 6.7 5 2 3 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41751.1 - 3.9e-05 23.4 1.8 0.74 10.0 0.0 5.7 5 1 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK41751.1 - 0.00021 21.5 3.9 2.4 8.4 0.3 4.2 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 PIK41751.1 - 0.00098 19.3 0.9 10 6.8 0.0 5.3 6 1 1 7 7 5 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK41751.1 - 0.0013 17.8 0.8 0.15 10.9 0.0 3.4 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 Com_YlbF PF06133.11 PIK41751.1 - 0.023 15.3 0.2 0.047 14.3 0.2 1.5 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA TPR_6 PF13174.6 PIK41751.1 - 0.027 15.1 0.8 6.7 7.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Arylesterase PF01731.20 PIK41752.1 - 1.6e-14 53.8 0.1 4.4e-14 52.4 0.1 1.7 2 0 0 2 2 2 1 Arylesterase Lactonase PF10282.9 PIK41752.1 - 0.0043 16.4 0.0 0.0089 15.3 0.0 1.4 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller SGL PF08450.12 PIK41752.1 - 0.0049 16.5 0.0 0.007 16.0 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 PIK41752.1 - 0.18 12.0 0.1 0.68 10.1 0.1 1.9 2 0 0 2 2 2 0 Strictosidine synthase Sushi PF00084.20 PIK41753.1 - 1.6e-13 51.1 2.3 3.3e-09 37.2 0.4 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Adeno_IVa2 PF02456.15 PIK41755.1 - 7.5e-07 28.3 0.0 1.7e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Adenovirus IVa2 protein Pox_A32 PF04665.12 PIK41755.1 - 1.8e-06 27.6 0.3 0.024 14.1 0.3 2.1 1 1 1 2 2 2 2 Poxvirus A32 protein AAA_14 PF13173.6 PIK41755.1 - 3.8e-05 23.7 0.0 8.9e-05 22.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain NB-ARC PF00931.22 PIK41755.1 - 0.002 17.4 0.0 0.013 14.7 0.0 1.9 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK41755.1 - 0.0054 17.0 0.0 0.0098 16.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 PIK41755.1 - 0.0077 16.7 0.0 0.018 15.4 0.0 1.6 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 PIK41755.1 - 0.011 15.4 0.0 0.023 14.5 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 PIK41755.1 - 0.012 16.0 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 PIK41755.1 - 0.014 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 PIK41755.1 - 0.016 15.1 0.1 0.03 14.2 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 PIK41755.1 - 0.021 14.7 0.0 0.045 13.7 0.0 1.5 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 PIK41755.1 - 0.022 15.2 0.0 0.074 13.5 0.0 1.9 2 0 0 2 2 2 0 RNA helicase PRTase_3 PF15610.6 PIK41755.1 - 0.033 13.5 0.2 0.073 12.3 0.2 1.5 1 1 0 1 1 1 0 PRTase ComF-like AAA_19 PF13245.6 PIK41755.1 - 0.033 14.5 0.0 0.036 14.4 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK41755.1 - 0.048 13.2 0.1 0.079 12.5 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 PIK41755.1 - 0.071 13.6 0.1 0.096 13.2 0.1 1.6 1 1 0 1 1 1 0 ABC transporter PhoH PF02562.16 PIK41755.1 - 0.087 12.3 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 PhoH-like protein TrwB_AAD_bind PF10412.9 PIK41755.1 - 0.11 11.4 0.0 0.34 9.8 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 PIK41755.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 PIK41755.1 - 0.15 11.4 0.0 1.6 8.0 0.0 2.2 2 1 0 3 3 3 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 PIK41755.1 - 0.16 11.2 0.0 0.35 10.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin GUB_WAK_bind PF13947.6 PIK41756.1 - 1.8e-05 25.4 0.1 0.19 12.5 0.0 2.1 1 1 1 2 2 2 2 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK41756.1 - 0.0074 16.0 0.1 5.7 6.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK41756.1 - 0.012 15.6 0.2 9.3 6.3 0.2 3.1 1 1 1 2 2 2 0 Interleukin 15 GUB_WAK_bind PF13947.6 PIK41757.1 - 0.00011 23.0 0.3 0.56 11.0 0.1 2.4 2 1 1 3 3 3 2 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK41757.1 - 0.0086 15.8 0.5 8 6.3 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK41757.1 - 0.01 15.8 0.8 14 5.7 0.1 3.3 1 1 1 3 3 3 0 Interleukin 15 PGM_PMM_IV PF00408.20 PIK41757.1 - 0.011 15.9 0.8 13 6.0 0.3 3.7 3 1 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain DapH_N PF08503.10 PIK41757.1 - 0.082 13.1 0.5 88 3.4 0.0 3.1 3 0 0 3 3 3 0 Tetrahydrodipicolinate succinyltransferase N-terminal SPT16 PF08644.11 PIK41757.1 - 0.11 12.6 3.9 0.22 11.7 1.8 2.1 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) DUF3786 PF12654.7 PIK41757.1 - 0.13 11.9 0.1 25 4.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3786) CAP18_C PF12153.8 PIK41757.1 - 3.1 7.7 10.6 26 4.8 0.2 3.8 4 0 0 4 4 4 0 LPS binding domain of CAP18 (C terminal) GUB_WAK_bind PF13947.6 PIK41758.1 - 0.0012 19.5 0.1 0.34 11.7 0.0 2.1 1 1 1 2 2 2 2 Wall-associated receptor kinase galacturonan-binding IL15 PF02372.15 PIK41758.1 - 0.1 12.6 0.1 12 5.9 0.0 2.9 1 1 2 3 3 3 0 Interleukin 15 GUB_WAK_bind PF13947.6 PIK41759.1 - 2.2e-08 34.8 0.3 0.34 11.7 0.0 3.1 1 1 2 3 3 3 3 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK41759.1 - 0.00013 21.6 0.5 10 5.9 0.0 3.4 3 0 0 3 3 3 3 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK41759.1 - 0.00034 20.6 0.7 17 5.4 0.1 4.3 1 1 2 3 3 3 2 Interleukin 15 DUF3786 PF12654.7 PIK41759.1 - 0.0066 16.1 0.0 32 4.1 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3786) Recombinase PF07508.13 PIK41759.1 - 0.063 13.7 0.4 39 4.7 0.0 3.1 3 0 0 3 3 3 0 Recombinase Transpos_assoc PF13963.6 PIK41759.1 - 0.075 13.4 2.1 67 3.9 0.1 3.2 3 0 0 3 3 3 0 Transposase-associated domain Cyanate_lyase PF02560.14 PIK41759.1 - 0.09 12.6 1.8 61 3.6 0.1 3.2 3 0 0 3 3 3 0 Cyanate lyase C-terminal domain CAP18_C PF12153.8 PIK41759.1 - 0.16 11.9 6.8 32 4.5 0.2 3.6 3 0 0 3 3 3 0 LPS binding domain of CAP18 (C terminal) EssA PF10661.9 PIK41759.1 - 0.48 10.3 4.9 20 5.0 0.2 3.3 1 1 2 3 3 3 0 WXG100 protein secretion system (Wss), protein EssA GUB_WAK_bind PF13947.6 PIK41760.1 - 1.8e-05 25.4 0.1 0.19 12.5 0.0 2.1 1 1 1 2 2 2 2 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK41760.1 - 0.0074 16.0 0.1 5.7 6.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK41760.1 - 0.012 15.6 0.2 9.3 6.3 0.2 3.1 1 1 1 2 2 2 0 Interleukin 15 GUB_WAK_bind PF13947.6 PIK41761.1 - 5.5e-05 23.9 0.1 0.32 11.8 0.0 2.1 1 1 0 2 2 2 2 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK41761.1 - 0.0062 16.3 0.1 4.5 7.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK41761.1 - 0.014 15.4 0.1 13 5.8 0.0 3.0 1 1 2 3 3 3 0 Interleukin 15 DUF1759 PF03564.15 PIK41762.1 - 0.0029 17.5 0.0 0.015 15.3 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Phage_Mu_Gam PF07352.12 PIK41762.1 - 0.034 14.1 1.4 0.063 13.2 1.4 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Herpes_teg_N PF04843.12 PIK41763.1 - 3.7e-10 39.7 0.0 6.6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Herpesvirus tegument protein, N-terminal conserved region FlgT_M PF16539.5 PIK41763.1 - 0.097 12.8 0.5 0.43 10.7 0.1 2.2 2 1 1 3 3 3 0 Flagellar assembly protein T, middle domain RVT_1 PF00078.27 PIK41764.1 - 2.5e-19 69.7 0.0 5.2e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Topo_Zn_Ribbon PF08272.11 PIK41764.1 - 0.36 10.5 0.1 0.36 10.5 0.1 2.8 3 0 0 3 3 3 0 Topoisomerase I zinc-ribbon-like fn3 PF00041.21 PIK41766.1 - 6.7e-12 45.6 1.4 3.8e-06 27.2 1.2 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK41766.1 - 9.3e-06 26.1 2.5 0.00063 20.3 1.9 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain REJ PF02010.15 PIK41766.1 - 0.0003 19.7 0.1 0.0018 17.2 0.1 1.9 1 1 0 1 1 1 1 REJ domain DUF4448 PF14610.6 PIK41766.1 - 0.013 15.3 0.0 0.029 14.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) GPI-anchored PF10342.9 PIK41766.1 - 0.013 16.2 4.6 0.055 14.2 3.0 2.2 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF5305 PF17231.2 PIK41766.1 - 0.028 13.8 0.9 0.044 13.2 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF3377 PF11857.8 PIK41766.1 - 0.053 13.4 0.5 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Y_phosphatase PF00102.27 PIK41767.1 - 9.7e-58 195.5 1.2 2.4e-34 118.9 0.2 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase PF00102.27 PIK41768.1 - 2.7e-98 328.2 1.3 1.9e-55 188.0 0.4 3.2 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK41768.1 - 0.00049 19.9 0.6 0.0013 18.5 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK41768.1 - 0.023 14.8 0.5 0.063 13.4 0.0 2.1 2 1 0 2 2 2 0 Inositol hexakisphosphate PHB_acc_N PF07879.11 PIK41768.1 - 0.023 14.8 0.9 5.1 7.3 0.1 2.8 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain DUF4781 PF16013.5 PIK41768.1 - 0.058 12.2 1.5 0.88 8.3 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4781) rve PF00665.26 PIK41769.1 - 1.4e-24 86.6 0.0 1.9e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41769.1 - 3.6e-19 68.6 3.2 5.9e-19 67.9 3.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK41769.1 - 2.5e-06 27.2 0.0 6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK41769.1 - 0.0002 21.5 0.8 0.0004 20.5 0.8 1.5 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK41770.1 - 3.3e-14 52.9 0.1 1.1e-13 51.2 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PNMA PF14893.6 PIK41771.1 - 0.046 13.1 0.8 0.052 13.0 0.8 1.1 1 0 0 1 1 1 0 PNMA zf-C2HE PF16278.5 PIK41771.1 - 0.052 14.0 0.7 0.11 13.0 0.1 1.9 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Calx-beta PF03160.14 PIK41772.1 - 0.00034 20.7 0.3 0.00058 20.0 0.0 1.5 2 0 0 2 2 2 1 Calx-beta domain Excalibur PF05901.11 PIK41773.1 - 0.0087 16.7 1.5 0.29 11.8 0.0 2.8 2 1 1 3 3 3 1 Excalibur calcium-binding domain zf-C2H2 PF00096.26 PIK41774.1 - 1.1e-33 113.8 130.8 5.4e-05 23.4 0.6 15.9 16 0 0 16 16 16 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK41774.1 - 7.3e-33 110.4 126.2 0.0031 18.2 0.9 15.7 15 0 0 15 15 15 14 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK41774.1 - 5.4e-27 93.0 116.0 3.5e-06 27.2 1.5 15.7 15 0 0 15 15 15 9 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK41774.1 - 1.8e-05 24.9 102.7 0.043 14.1 0.3 15.7 15 1 1 16 16 16 7 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 PIK41774.1 - 0.0058 17.3 57.2 0.016 15.9 4.1 9.7 4 3 5 9 9 9 3 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 PIK41774.1 - 0.0067 16.4 113.4 0.052 13.6 0.3 14.9 15 0 0 15 15 15 7 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK41774.1 - 0.038 13.7 0.1 0.038 13.7 0.1 10.4 11 0 0 11 11 11 0 zinc-finger C2H2-type BHD_1 PF10403.9 PIK41774.1 - 0.21 11.5 1.8 1.9 8.4 0.1 3.2 3 0 0 3 3 3 0 Rad4 beta-hairpin domain 1 BolA PF01722.18 PIK41774.1 - 8.5 6.7 19.9 0.18 12.1 0.7 4.9 5 1 0 5 5 5 0 BolA-like protein YIF1 PF03878.15 PIK41775.1 - 9e-81 270.9 1.9 1e-80 270.7 1.9 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 PIK41775.1 - 0.00055 19.7 6.9 0.0042 16.8 6.4 2.1 1 1 0 1 1 1 1 Yip1 domain ApoA-II PF04711.13 PIK41775.1 - 0.025 14.7 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) Ribosomal_L14 PF00238.19 PIK41776.1 - 1.1e-17 64.2 0.0 3.4e-17 62.6 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e RVT_1 PF00078.27 PIK41777.1 - 1e-07 31.7 0.0 4.1e-06 26.5 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK41777.1 - 5.7e-06 26.3 0.1 1e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase EcoEI_R_C PF08463.10 PIK41777.1 - 0.005 17.0 0.1 0.0064 16.6 0.1 1.2 1 0 0 1 1 1 1 EcoEI R protein C-terminal SNF2_assoc PF08455.10 PIK41777.1 - 0.025 13.6 0.1 0.034 13.2 0.1 1.2 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated T4-Gluco-transf PF09198.10 PIK41777.1 - 0.1 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase eIF-1a PF01176.19 PIK41778.1 - 5.7e-18 64.5 0.1 9.9e-18 63.7 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 MBOAT PF03062.19 PIK41779.1 - 1.2e-18 67.6 3.1 2.2e-18 66.7 3.1 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Dpy-30 PF05186.13 PIK41780.1 - 4.5e-17 61.5 0.1 1.1e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 Dpy-30 motif ADK PF00406.22 PIK41780.1 - 1.4e-08 35.0 0.1 1.1e-07 32.1 0.1 2.4 1 1 0 1 1 1 1 Adenylate kinase DNA_pol3_theta PF06440.11 PIK41780.1 - 0.0093 15.6 0.0 0.036 13.7 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase III, theta subunit DUF1840 PF08895.11 PIK41780.1 - 2 8.8 17.9 3.2 8.1 5.3 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1840) Nuc_sug_transp PF04142.15 PIK41781.1 - 1.1e-37 129.8 24.9 1.4e-37 129.6 24.9 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 PIK41781.1 - 1.2e-06 28.8 31.0 0.0031 17.7 9.2 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 PIK41781.1 - 0.00014 21.2 23.2 0.00019 20.8 23.2 1.2 1 0 0 1 1 1 1 UAA transporter family ECF-ribofla_trS PF07155.12 PIK41781.1 - 0.0022 18.0 4.6 0.0022 18.0 4.6 3.1 2 2 2 4 4 4 1 ECF-type riboflavin transporter, S component YlaH PF14036.6 PIK41781.1 - 0.023 15.0 0.8 0.023 15.0 0.8 3.6 4 0 0 4 4 4 0 YlaH-like protein PUNUT PF16913.5 PIK41781.1 - 0.05 12.8 22.4 0.027 13.7 6.8 2.7 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport TPT PF03151.16 PIK41781.1 - 1.8 7.8 24.1 0.11 11.8 3.9 2.5 2 1 0 2 2 2 0 Triose-phosphate Transporter family WBP-1 PF11669.8 PIK41781.1 - 6.5 7.4 6.1 14 6.4 1.1 2.8 2 1 0 2 2 2 0 WW domain-binding protein 1 Macro PF01661.21 PIK41782.1 - 4.2e-35 120.3 0.0 7e-35 119.6 0.0 1.4 1 0 0 1 1 1 1 Macro domain CAP PF00188.26 PIK41783.1 - 3.7e-13 50.4 2.4 6.5e-13 49.6 2.4 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family FAM176 PF14851.6 PIK41783.1 - 0.19 11.4 1.0 0.35 10.5 1.0 1.4 1 0 0 1 1 1 0 FAM176 family Conotoxin PF02950.17 PIK41783.1 - 0.3 12.1 2.3 7.3 7.7 0.1 2.9 2 1 0 2 2 2 0 Conotoxin ubiquitin PF00240.23 PIK41784.1 - 8.8e-72 236.8 15.5 4.4e-20 71.2 0.1 6.4 7 0 0 7 7 7 5 Ubiquitin family Rad60-SLD PF11976.8 PIK41784.1 - 3e-24 84.6 9.4 4.7e-09 36.0 0.0 5.7 6 0 0 6 6 6 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK41784.1 - 2.9e-08 34.0 11.8 0.15 12.5 0.2 5.6 4 1 1 5 5 5 3 Ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK41784.1 - 1.6e-07 31.3 7.6 0.03 14.4 0.3 6.2 4 4 2 6 6 6 3 Ubiquitin-like domain DUF2407 PF10302.9 PIK41784.1 - 2.7e-07 31.1 2.0 0.092 13.3 0.1 4.4 3 1 1 4 4 4 2 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK41784.1 - 2.3e-06 27.6 0.4 0.64 10.1 0.0 4.5 3 1 1 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 PIK41784.1 - 3.9e-05 23.5 6.7 0.25 11.3 0.0 5.2 4 1 1 5 5 5 2 TANK binding kinase 1 ubiquitin-like domain TUG-UBL1 PF11470.8 PIK41784.1 - 5.9e-05 23.2 0.1 0.00043 20.5 0.0 2.5 3 0 0 3 3 3 1 TUG ubiquitin-like domain UN_NPL4 PF11543.8 PIK41784.1 - 6.5e-05 23.3 2.7 4.9 7.7 0.1 4.9 5 0 0 5 5 5 1 Nuclear pore localisation protein NPL4 Ubiquitin_5 PF18037.1 PIK41784.1 - 0.00033 20.9 3.6 0.017 15.5 0.0 3.7 4 0 0 4 4 4 1 Ubiquitin-like domain USP7_C2 PF14533.6 PIK41784.1 - 0.067 12.9 1.2 2.1 8.0 0.0 3.2 3 1 1 4 4 4 0 Ubiquitin-specific protease C-terminal ubiquitin PF00240.23 PIK41785.1 - 1.3e-35 121.0 4.7 6.5e-13 48.2 0.1 5.0 5 1 0 5 5 5 4 Ubiquitin family Rad60-SLD PF11976.8 PIK41785.1 - 1.8e-10 40.5 0.6 0.0016 18.3 0.0 3.5 4 0 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK41785.1 - 5e-06 26.9 2.1 4 7.9 0.2 4.6 4 1 0 4 4 4 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK41785.1 - 5e-06 26.6 0.1 0.052 13.6 0.0 3.7 3 2 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 PIK41785.1 - 1.3e-05 25.0 0.1 0.39 10.7 0.0 3.4 3 0 0 3 3 3 2 TANK binding kinase 1 ubiquitin-like domain UN_NPL4 PF11543.8 PIK41785.1 - 0.00059 20.3 1.1 4.6 7.8 0.1 4.0 3 1 1 4 4 4 2 Nuclear pore localisation protein NPL4 APG12 PF04110.13 PIK41785.1 - 0.059 13.8 0.0 11 6.5 0.0 2.9 3 0 0 3 3 3 0 Ubiquitin-like autophagy protein Apg12 IL13 PF03487.13 PIK41785.1 - 0.1 12.4 0.0 0.43 10.4 0.0 1.9 2 0 0 2 2 2 0 Interleukin-13 Ubiquitin_5 PF18037.1 PIK41785.1 - 0.11 12.9 0.8 2.4 8.6 0.0 2.8 2 1 1 3 3 3 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK41785.1 - 0.13 12.3 4.0 31 4.7 0.0 4.8 3 2 2 5 5 5 0 Ubiquitin-like domain ABC_membrane PF00664.23 PIK41786.1 - 5.1e-29 101.8 15.5 5.1e-29 101.8 15.5 2.2 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK41786.1 - 1.5e-21 77.3 0.0 2.4e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK41786.1 - 0.019 14.4 0.6 0.58 9.6 0.2 2.2 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 PIK41786.1 - 0.023 14.8 0.2 0.051 13.7 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 PIK41786.1 - 0.027 14.2 0.2 0.068 12.9 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 PIK41786.1 - 0.089 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 PIK41786.1 - 0.091 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Dynamin family MMR_HSR1 PF01926.23 PIK41786.1 - 0.095 12.8 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK41786.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase TrwB_AAD_bind PF10412.9 PIK41786.1 - 0.16 10.8 0.4 0.26 10.1 0.4 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.6 PIK41786.1 - 0.18 12.2 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK41787.1 - 2e-32 112.6 0.0 3.7e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK41787.1 - 5e-23 82.1 0.8 8.1e-23 81.4 0.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK41787.1 - 0.00059 19.3 2.0 0.061 12.7 0.1 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 PIK41787.1 - 0.0055 16.5 0.1 0.49 10.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 PIK41787.1 - 0.019 15.0 0.1 0.048 13.7 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.17 PIK41787.1 - 0.049 13.7 0.1 0.091 12.8 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 PIK41787.1 - 0.065 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 PIK41787.1 - 0.073 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Kri1_C PF12936.7 PIK41788.1 - 1.6e-28 98.7 1.1 1.6e-28 98.7 1.1 6.2 7 0 0 7 7 7 1 KRI1-like family C-terminal Kri1 PF05178.12 PIK41788.1 - 6.9e-19 68.3 14.9 6.9e-19 68.3 14.9 7.1 4 2 3 7 7 7 1 KRI1-like family Siva PF05458.12 PIK41789.1 - 0.00099 18.8 0.2 0.00099 18.8 0.2 2.3 3 0 0 3 3 3 1 Cd27 binding protein (Siva) zf-H2C2_2 PF13465.6 PIK41790.1 - 2.2e-08 34.2 16.0 1e-05 25.7 2.1 3.8 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41790.1 - 5e-05 23.8 26.4 0.011 16.5 1.5 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK41790.1 - 0.00043 20.0 0.3 0.00043 20.0 0.3 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-C2H2 PF00096.26 PIK41790.1 - 0.0044 17.4 11.2 0.019 15.4 2.0 4.5 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK41790.1 - 0.023 15.0 2.7 0.023 15.0 2.7 3.4 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK41790.1 - 0.034 14.1 1.1 0.034 14.1 1.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.15 PIK41790.1 - 0.05 13.6 15.5 0.75 9.9 0.3 4.2 3 1 1 4 4 4 0 BED zinc finger zf-H2C2_5 PF13909.6 PIK41790.1 - 0.13 12.0 17.2 0.74 9.6 0.0 3.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 PIK41790.1 - 2.5 8.5 15.9 1.5 9.2 2.5 3.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK41793.1 - 8.1e-19 67.1 36.5 1.3e-06 28.6 0.2 6.2 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41793.1 - 4.7e-15 55.0 36.2 0.00073 20.2 2.0 5.3 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK41793.1 - 9.7e-10 38.4 38.6 0.022 15.2 4.0 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-BED PF02892.15 PIK41793.1 - 0.0017 18.4 30.2 0.019 15.0 0.4 5.3 1 1 4 5 5 5 3 BED zinc finger Sel_put PF04328.13 PIK41793.1 - 0.0047 16.9 1.3 0.0047 16.9 1.3 2.4 2 1 0 2 2 2 1 Selenoprotein, putative zf-C2H2_jaz PF12171.8 PIK41793.1 - 0.017 15.4 30.9 0.088 13.1 0.9 6.8 5 2 1 6 6 6 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 PIK41793.1 - 0.13 13.1 14.1 2.8 8.7 0.9 3.3 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_2 PF12756.7 PIK41793.1 - 0.15 12.4 27.6 0.37 11.2 0.7 4.3 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-FLZ PF04570.14 PIK41793.1 - 0.62 9.6 0.1 0.62 9.6 0.1 3.8 5 0 0 5 5 5 0 zinc-finger of the FCS-type, C2-C2 PHD_4 PF16866.5 PIK41793.1 - 1.6 8.9 13.0 1.2 9.3 0.7 3.0 2 1 1 3 3 3 0 PHD-finger PyrI_C PF02748.15 PIK41793.1 - 1.8 8.5 14.3 0.31 11.0 0.5 4.3 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PHD PF00628.29 PIK41793.1 - 3.6 7.6 22.6 0.61 10.0 3.5 3.4 2 1 1 3 3 3 0 PHD-finger zf-CHCC PF10276.9 PIK41793.1 - 3.7 7.7 7.2 5.6 7.1 0.3 3.6 4 0 0 4 4 4 0 Zinc-finger domain DZR PF12773.7 PIK41793.1 - 6.9 6.8 18.1 1.8e+04 -5.0 18.1 3.2 1 1 0 1 1 0 0 Double zinc ribbon DUF5641 PF18701.1 PIK41794.1 - 6.6e-11 42.2 0.2 1.4e-10 41.2 0.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK41794.1 - 3.7e-08 33.6 0.0 6.4e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK41794.1 - 0.018 15.1 3.0 0.018 15.1 3.0 1.9 2 0 0 2 2 2 0 Integrase zinc binding domain NYD-SP28_assoc PF14775.6 PIK41794.1 - 0.033 14.3 0.0 0.098 12.8 0.0 1.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain RNHCP PF12647.7 PIK41794.1 - 0.091 12.7 0.1 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 RNHCP domain zf-C2H2_4 PF13894.6 PIK41796.1 - 1.2e-08 35.0 22.4 0.0021 18.7 1.7 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK41796.1 - 0.00031 21.0 12.4 0.32 11.5 0.7 4.3 4 1 0 4 4 4 2 Zinc-finger double domain PyrI_C PF02748.15 PIK41796.1 - 0.0011 18.8 7.8 0.25 11.3 0.5 3.8 3 1 1 4 4 4 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 PF00096.26 PIK41796.1 - 0.0013 19.1 2.7 0.0013 19.1 2.7 4.6 4 2 0 4 4 4 2 Zinc finger, C2H2 type zf-BED PF02892.15 PIK41796.1 - 0.0028 17.7 15.5 0.58 10.2 0.2 3.9 2 1 1 3 3 3 2 BED zinc finger zf-C2H2_jaz PF12171.8 PIK41796.1 - 0.0058 16.9 13.4 0.64 10.4 0.4 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK41796.1 - 0.19 11.6 0.3 0.19 11.6 0.3 3.4 4 0 0 4 4 3 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.5 PIK41796.1 - 0.28 12.0 6.3 0.71 10.7 0.9 2.3 1 1 1 2 2 2 0 zinc-ribbon family zf-met PF12874.7 PIK41796.1 - 0.35 11.3 6.1 7.1 7.2 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-U1 PF06220.12 PIK41796.1 - 0.48 10.2 5.5 0.72 9.7 0.3 2.8 2 0 0 2 2 2 0 U1 zinc finger C1_2 PF03107.16 PIK41796.1 - 0.57 10.5 12.0 6.6 7.1 3.4 3.8 2 1 1 3 3 3 0 C1 domain Desulfoferrod_N PF06397.12 PIK41796.1 - 0.7 9.6 0.1 0.7 9.6 0.1 2.5 3 0 0 3 3 2 0 Desulfoferrodoxin, N-terminal domain DZR PF12773.7 PIK41796.1 - 0.74 9.9 6.8 17 5.5 6.8 2.5 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 PIK41796.1 - 0.96 9.6 9.9 6.6 7.0 0.1 2.8 2 1 0 2 2 2 0 FYVE zinc finger zf_UBZ PF18439.1 PIK41796.1 - 3.5 7.3 10.4 2.5 7.8 0.1 3.8 4 1 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Actin_micro PF17003.5 PIK41796.1 - 4.6 6.3 7.1 70 2.4 7.1 2.5 1 1 0 1 1 1 0 Putative actin-like family zf-C2H2_2 PF12756.7 PIK41796.1 - 4.8 7.6 13.7 7.7 6.9 0.3 3.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 PIK41797.1 - 1.5e-13 50.5 15.9 6.2e-06 26.4 0.3 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41797.1 - 3.5e-09 36.7 11.1 0.00093 19.8 1.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK41797.1 - 1e-06 28.8 13.4 0.027 14.9 2.0 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK41797.1 - 4e-05 23.8 4.0 0.66 10.3 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK41797.1 - 0.0011 19.3 7.2 0.028 14.8 0.1 3.5 3 1 0 3 3 3 1 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK41797.1 - 0.0016 18.4 13.3 0.26 11.3 0.4 3.5 2 1 1 3 3 3 2 BED zinc finger PyrI_C PF02748.15 PIK41797.1 - 0.002 18.0 2.3 0.22 11.5 0.1 3.1 3 0 0 3 3 3 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 PIK41797.1 - 0.0039 17.5 6.4 0.61 10.5 0.3 3.1 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) Ribosomal_L28 PF00830.19 PIK41797.1 - 0.0063 16.7 1.3 0.085 13.1 0.3 2.3 2 0 0 2 2 2 1 Ribosomal L28 family C1_2 PF03107.16 PIK41797.1 - 0.032 14.6 8.9 0.71 10.2 0.3 3.1 2 1 0 2 2 2 0 C1 domain DUF2175 PF09943.9 PIK41797.1 - 0.086 13.1 0.7 0.086 13.1 0.7 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) DZR PF12773.7 PIK41797.1 - 0.097 12.7 6.3 11 6.2 6.3 2.3 1 1 0 1 1 1 0 Double zinc ribbon zf_UBZ PF18439.1 PIK41797.1 - 0.12 12.0 4.0 0.4 10.3 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 PIK41797.1 - 0.17 12.1 4.7 7.7 6.8 0.2 3.4 3 0 0 3 3 3 0 AN1-like Zinc finger Zf_RING PF16744.5 PIK41797.1 - 0.23 11.6 6.6 3.4 7.8 0.3 3.1 2 1 1 3 3 3 0 KIAA1045 RING finger zinc_ribbon_15 PF17032.5 PIK41797.1 - 0.36 11.6 5.0 1.9 9.3 1.7 2.2 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_6 PF13912.6 PIK41797.1 - 0.55 10.3 14.0 4.4 7.4 0.1 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Sec23_Sec24 PF04810.15 PIK41797.1 - 0.57 10.3 0.2 0.57 10.3 0.2 3.0 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger DUF3449 PF11931.8 PIK41797.1 - 0.59 9.9 2.9 5.7 6.7 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) ZZ PF00569.17 PIK41797.1 - 1.3 8.9 7.5 0.25 11.2 0.6 2.6 3 0 0 3 3 2 0 Zinc finger, ZZ type zf-C2HC_2 PF13913.6 PIK41797.1 - 3.3 7.7 8.2 0.44 10.5 0.6 2.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Peptidase_M3 PF01432.20 PIK41798.1 - 1.2e-154 516.0 0.2 2e-154 515.2 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M2 PF01401.18 PIK41798.1 - 0.0036 16.0 0.4 0.0069 15.1 0.4 1.5 1 0 0 1 1 1 1 Angiotensin-converting enzyme Ribosomal_L17 PF01196.19 PIK41798.1 - 0.051 14.5 0.3 0.21 12.5 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein L17 Gp-FAR-1 PF05823.12 PIK41798.1 - 1.2 9.5 6.7 0.15 12.4 1.0 2.4 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) KMP11 PF03037.16 PIK41798.1 - 4.7 8.1 6.6 0.56 11.0 1.0 2.5 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 DUF829 PF05705.14 PIK41799.1 - 4.6e-52 177.3 0.0 5.3e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) FGE-sulfatase PF03781.16 PIK41800.1 - 9.5e-14 51.6 0.1 9.6e-13 48.3 0.1 2.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 PIK41800.1 - 5e-06 27.0 0.0 9.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 DinB superfamily SNF2_N PF00176.23 PIK41801.1 - 6.6e-44 150.1 0.8 1.1e-43 149.3 0.8 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK41801.1 - 1.8e-19 70.1 0.0 1.4e-17 64.0 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK41801.1 - 1.2e-08 35.1 0.4 1.2e-07 31.9 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit VIGSSK PF14773.6 PIK41801.1 - 3.6e-07 30.2 0.1 2.3e-06 27.6 0.1 2.5 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal SMN PF06003.12 PIK41801.1 - 0.0001 21.7 0.0 0.0001 21.7 0.0 3.3 4 0 0 4 4 4 1 Survival motor neuron protein (SMN) Agenet PF05641.12 PIK41801.1 - 0.036 14.5 0.0 0.15 12.5 0.0 2.1 1 0 0 1 1 1 0 Agenet domain TUDOR PF00567.24 PIK41801.1 - 0.053 13.6 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Tudor domain U1snRNP70_N PF12220.8 PIK41801.1 - 1 10.0 12.2 0.66 10.7 3.6 3.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal zf-H2C2_2 PF13465.6 PIK41802.1 - 3.2e-26 90.5 98.6 1.4e-05 25.2 1.9 14.4 13 1 1 14 14 14 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK41802.1 - 7.1e-24 82.9 103.9 0.0041 17.5 0.9 14.2 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK41802.1 - 3e-23 80.5 101.5 0.012 16.4 0.8 14.0 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK41802.1 - 0.00092 19.2 0.2 0.00092 19.2 0.2 14.0 14 0 0 14 14 14 5 C2H2-type zinc finger FAM75 PF14650.6 PIK41802.1 - 0.12 11.9 1.6 0.24 10.9 1.6 1.5 1 0 0 1 1 1 0 FAM75 family DUF2623 PF11115.8 PIK41802.1 - 0.29 11.2 4.3 0.43 10.7 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2623) NS3 PF17530.2 PIK41802.1 - 2.2 7.8 11.0 0.34 10.4 1.5 3.1 2 1 1 4 4 4 0 Non-structural protein NS3 zf-C2H2_jaz PF12171.8 PIK41802.1 - 6.3 7.2 90.4 0.099 13.0 3.7 12.7 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 PIK41802.1 - 8.9 6.7 35.8 4.1 7.7 0.0 7.8 10 0 0 10 10 10 0 zinc-ribbon F-box PF00646.33 PIK41803.1 - 2.2e-05 24.2 1.1 4.2e-05 23.3 1.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK41803.1 - 0.00028 20.7 0.2 0.00063 19.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like FAM76 PF16046.5 PIK41803.1 - 0.0029 17.0 3.7 0.0029 17.0 3.7 2.2 3 0 0 3 3 3 1 FAM76 protein HAP1_N PF04849.13 PIK41803.1 - 0.0043 16.3 4.6 0.0043 16.3 4.6 1.8 2 0 0 2 2 2 1 HAP1 N-terminal conserved region F-box_4 PF15966.5 PIK41803.1 - 0.0064 16.4 0.5 0.016 15.1 0.5 1.6 1 0 0 1 1 1 1 F-box Taxilin PF09728.9 PIK41803.1 - 0.013 14.7 8.5 0.038 13.2 8.0 1.9 2 0 0 2 2 2 0 Myosin-like coiled-coil protein ATG16 PF08614.11 PIK41803.1 - 0.024 14.9 6.1 0.075 13.3 6.1 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 PIK41803.1 - 0.024 14.7 7.2 0.078 13.0 7.2 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BRE1 PF08647.11 PIK41803.1 - 0.085 12.9 7.6 0.3 11.2 7.6 2.0 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase FH2 PF02181.23 PIK41803.1 - 0.16 11.0 7.0 0.1 11.7 4.1 1.9 2 0 0 2 2 2 0 Formin Homology 2 Domain USP8_interact PF08941.10 PIK41803.1 - 0.29 10.9 8.0 0.71 9.7 4.3 2.4 1 1 1 2 2 2 0 USP8 interacting TMPIT PF07851.13 PIK41803.1 - 0.46 9.7 3.3 0.89 8.7 3.3 1.4 1 0 0 1 1 1 0 TMPIT-like protein CHDCT2 PF08074.11 PIK41803.1 - 0.48 10.6 3.5 0.59 10.3 0.1 2.5 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain TMF_DNA_bd PF12329.8 PIK41803.1 - 0.83 9.7 14.3 7.8 6.6 10.7 3.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 PIK41803.1 - 0.95 9.6 10.5 3.6 7.8 4.8 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 PIK41803.1 - 0.96 10.1 13.1 0.06 14.0 5.2 2.9 2 1 1 3 3 3 0 SlyX ETAA1 PF15350.6 PIK41804.1 - 3.9e-08 32.1 2.9 4.4e-08 31.9 2.9 1.1 1 0 0 1 1 1 1 Ewing's tumour-associated antigen 1 homologue DUF5302 PF17227.2 PIK41804.1 - 0.05 14.6 0.3 0.14 13.2 0.3 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5302) WW PF00397.26 PIK41804.1 - 0.33 11.1 6.5 2.7 8.2 1.2 2.5 2 0 0 2 2 2 0 WW domain TPD PF14811.6 PIK41806.1 - 1e-44 151.7 0.1 1.7e-44 151.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif Init_tRNA_PT PF04179.12 PIK41806.1 - 0.065 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain Il2rg PF15874.5 PIK41807.1 - 0.011 16.0 0.0 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain Meis_PKNOX_N PF16493.5 PIK41808.1 - 2.9e-44 149.3 0.7 5.3e-44 148.5 0.7 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 PIK41808.1 - 1.2e-20 73.1 1.0 2.3e-20 72.2 1.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 PIK41808.1 - 2e-08 34.0 0.5 2e-08 34.0 0.5 1.8 2 0 0 2 2 2 1 Homeodomain RNase_J_C PF17770.1 PIK41809.1 - 0.11 13.6 0.7 4.5 8.4 0.0 3.6 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain AAA_12 PF13087.6 PIK41811.1 - 1e-48 165.6 0.0 2.5e-48 164.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK41811.1 - 6.2e-24 85.2 0.4 4.7e-18 65.9 0.3 2.9 2 1 1 3 3 3 2 AAA domain zf-GRF PF06839.12 PIK41811.1 - 1.6e-13 50.5 8.0 3.1e-13 49.6 8.0 1.5 1 0 0 1 1 1 1 GRF zinc finger Viral_helicase1 PF01443.18 PIK41811.1 - 2.6e-05 24.1 0.0 0.11 12.2 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 PIK41811.1 - 0.0084 15.9 0.1 0.03 14.2 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Pex14_N PF04695.13 PIK41813.1 - 6.1e-23 82.2 4.1 6.1e-23 82.2 4.1 3.7 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region HMMR_N PF15905.5 PIK41813.1 - 0.00073 19.1 0.5 0.00073 19.1 0.5 1.8 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal DUF1664 PF07889.12 PIK41813.1 - 0.0016 18.5 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 PIK41813.1 - 3 8.4 6.7 0.79 10.3 1.1 2.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal GST_C_3 PF14497.6 PIK41814.1 - 1e-15 57.7 0.1 1.2e-15 57.4 0.1 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK41814.1 - 9.1e-06 25.8 0.1 1.3e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK41814.1 - 0.013 15.5 0.0 0.027 14.5 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK41815.1 - 2e-19 69.6 0.0 3.1e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK41815.1 - 7.7e-10 39.0 0.2 1.8e-09 37.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK41815.1 - 2.4e-06 27.7 0.0 3.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK41815.1 - 5.3e-05 23.2 0.0 8.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK41815.1 - 0.0056 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK41815.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain USP8_dimer PF08969.11 PIK41816.1 - 1.5e-15 57.4 2.0 3e-15 56.4 2.0 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain DUF5320 PF17253.2 PIK41816.1 - 2.3 9.3 9.9 0.64 11.1 6.5 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF2229 PF09989.9 PIK41816.1 - 5.1 6.7 9.8 5.1 6.7 1.8 2.8 2 1 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) JAB PF01398.21 PIK41817.1 - 2e-15 56.8 0.0 2.8e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 PIK41817.1 - 1.6e-06 27.8 0.0 1.6e-06 27.8 0.0 1.5 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Death PF00531.22 PIK41818.1 - 1.2e-13 51.0 7.3 3.9e-05 23.7 0.0 4.4 5 0 0 5 5 5 3 Death domain Helicase_Sgs1 PF11408.8 PIK41818.1 - 0.07 13.2 0.9 0.7 10.0 0.1 2.8 3 0 0 3 3 3 0 Sgs1 RecQ helicase Sulfotransfer_2 PF03567.14 PIK41819.1 - 4.2e-12 46.5 0.4 5.4e-12 46.2 0.4 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK41819.1 - 2.9e-10 40.1 0.3 1e-09 38.3 0.3 1.7 1 1 0 1 1 1 1 Sulfotransferase domain DUF4129 PF13559.6 PIK41819.1 - 0.029 14.6 0.0 0.085 13.1 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) YfkB PF08756.10 PIK41819.1 - 0.09 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 YfkB-like domain zf-NADH-PPase PF09297.11 PIK41820.1 - 0.00019 21.0 6.2 0.00033 20.2 6.2 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.11 PIK41820.1 - 0.00029 21.5 0.0 0.00047 20.8 0.0 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain RecR PF02132.15 PIK41820.1 - 0.015 14.8 1.6 0.044 13.4 1.6 1.7 1 0 0 1 1 1 0 RecR protein Invasin_D3 PF09134.10 PIK41821.1 - 0.042 14.1 0.2 3.4 8.0 0.0 2.8 2 1 0 2 2 2 0 Invasin, domain 3 Cadherin PF00028.17 PIK41822.1 - 1.4e-50 169.7 27.4 2.1e-08 34.5 0.2 9.7 9 0 0 9 9 9 8 Cadherin domain Cadherin_pro PF08758.11 PIK41822.1 - 3.8e-05 23.8 0.9 0.02 15.0 0.1 3.4 3 0 0 3 3 3 2 Cadherin prodomain like Cadherin_3 PF16184.5 PIK41822.1 - 0.025 14.6 7.4 0.44 10.6 0.2 4.8 5 0 0 5 5 5 0 Cadherin-like DUF4711 PF15829.5 PIK41822.1 - 0.14 12.1 0.3 0.46 10.4 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4711) SPC25 PF06703.11 PIK41822.1 - 0.61 9.9 3.5 1.2 9.0 0.1 3.1 3 1 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Cadherin PF00028.17 PIK41823.1 - 1.3e-32 112.0 11.3 1.2e-10 41.7 0.2 7.2 7 0 0 7 7 7 5 Cadherin domain Cadherin_3 PF16184.5 PIK41823.1 - 1.9e-06 27.8 6.5 0.12 12.3 0.1 6.1 6 1 1 7 7 7 2 Cadherin-like He_PIG PF05345.12 PIK41823.1 - 0.0092 16.2 25.3 0.016 15.4 0.2 6.8 7 1 0 7 7 7 3 Putative Ig domain Cadherin PF00028.17 PIK41824.1 - 8.9e-33 112.6 9.5 2.4e-16 59.9 0.3 3.3 3 0 0 3 3 3 3 Cadherin domain Cadherin PF00028.17 PIK41825.1 - 1e-64 215.0 29.4 2.6e-11 43.8 0.1 10.2 10 0 0 10 10 10 8 Cadherin domain Cadherin_3 PF16184.5 PIK41825.1 - 7.9e-12 45.2 8.7 0.0019 18.2 0.0 5.9 5 0 0 5 5 5 3 Cadherin-like Cadherin_2 PF08266.12 PIK41825.1 - 0.0002 21.1 0.0 0.22 11.4 0.1 4.4 5 0 0 5 5 5 1 Cadherin-like RET_CLD1 PF17756.1 PIK41825.1 - 0.0031 17.8 0.1 0.72 10.1 0.0 3.8 4 0 0 4 4 4 1 RET Cadherin like domain 1 KSHV_K8 PF07188.11 PIK41825.1 - 0.12 11.7 0.2 0.24 10.8 0.2 1.4 1 0 0 1 1 1 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein Invasin_D3 PF09134.10 PIK41825.1 - 5.1 7.5 14.6 13 6.2 0.1 5.8 6 0 0 6 6 6 0 Invasin, domain 3 Ig_3 PF13927.6 PIK41826.1 - 0.0001 22.8 1.0 0.052 14.2 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin domain SID-1_RNA_chan PF13965.6 PIK41826.1 - 0.0039 15.7 0.7 0.0059 15.1 0.7 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF4834 PF16118.5 PIK41826.1 - 0.0042 18.0 0.1 0.009 17.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Cadherin_C_2 PF16492.5 PIK41826.1 - 0.0073 17.0 0.0 0.024 15.4 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal EphA2_TM PF14575.6 PIK41826.1 - 0.015 16.1 0.4 0.031 15.1 0.4 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2561 PF10812.8 PIK41826.1 - 0.016 15.3 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) ig PF00047.25 PIK41826.1 - 0.016 15.3 0.3 0.13 12.5 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin domain Ish1 PF10281.9 PIK41826.1 - 0.07 13.5 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein DUF3377 PF11857.8 PIK41826.1 - 0.079 12.9 0.5 0.26 11.2 0.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) MLANA PF14991.6 PIK41826.1 - 0.17 12.2 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A WBP-1 PF11669.8 PIK41826.1 - 0.21 12.2 1.3 0.42 11.3 0.2 2.0 2 0 0 2 2 2 0 WW domain-binding protein 1 Pkinase_Tyr PF07714.17 PIK41827.1 - 1.1e-09 38.0 0.0 2.2e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK41828.1 - 0.00019 22.0 0.3 0.16 12.6 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK41828.1 - 0.0057 17.0 0.6 0.4 11.1 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK41828.1 - 0.017 15.3 0.5 0.33 11.2 0.1 2.9 3 0 0 3 3 3 0 Immunoglobulin domain DUF3377 PF11857.8 PIK41828.1 - 0.039 13.9 0.1 0.039 13.9 0.1 4.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 PIK41828.1 - 0.48 10.3 0.0 0.48 10.3 0.0 4.9 2 1 0 2 2 2 0 TMEM154 protein family Pkinase_Tyr PF07714.17 PIK41829.1 - 1.4e-47 162.2 0.0 1.7e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41829.1 - 1.8e-15 57.0 0.0 2.6e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain GAPT PF11770.8 PIK41829.1 - 0.16 11.8 1.3 0.26 11.1 1.1 1.6 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) Nup160 PF11715.8 PIK41831.1 - 4.6e-50 170.8 0.0 4.4e-37 127.9 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 MFAP1 PF06991.11 PIK41832.1 - 3.1e-74 249.5 29.1 3.1e-74 249.5 29.1 2.5 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing GSG-1 PF07803.11 PIK41832.1 - 0.07 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 GSG1-like protein Bromo_TP PF07524.13 PIK41833.1 - 7.4e-20 70.8 0.1 1.4e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 PIK41833.1 - 4.7e-17 62.3 0.4 1.2e-16 61.0 0.4 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP_like PF17027.5 PIK41833.1 - 0.0067 16.6 0.0 0.014 15.5 0.0 1.6 2 0 0 2 2 2 1 Histone-fold protein CENP-S PF15630.6 PIK41833.1 - 0.13 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 CENP-S protein SCNM1_acidic PF15805.5 PIK41836.1 - 4.1e-19 68.0 5.6 9e-19 66.9 5.6 1.6 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 zf-SCNM1 PF15803.5 PIK41836.1 - 1.3e-11 43.9 5.9 2.9e-11 42.8 5.9 1.6 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 CdiA_C PF18451.1 PIK41836.1 - 0.15 12.3 1.1 0.4 10.9 0.2 2.2 2 1 1 3 3 3 0 Contact-dependent growth inhibition CdiA C-terminal domain EIIBC-GUT_N PF03612.14 PIK41836.1 - 5.2 6.8 6.7 1.5 8.6 0.1 2.7 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus zf-RING_4 PF14570.6 PIK41837.1 - 1.5e-20 72.7 12.1 3.6e-20 71.5 12.1 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 PIK41837.1 - 2e-07 30.7 0.0 4.7e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 PIK41837.1 - 1.8e-05 24.5 10.7 1.8e-05 24.5 10.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK41837.1 - 0.0053 17.1 10.5 0.0053 17.1 10.5 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK41837.1 - 0.006 16.4 9.9 0.006 16.4 9.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Nup35_RRM_2 PF14605.6 PIK41837.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Torus PF16131.5 PIK41837.1 - 0.014 16.1 0.3 0.048 14.4 0.3 2.0 1 0 0 1 1 1 0 Torus domain zf-C3HC4 PF00097.25 PIK41837.1 - 0.024 14.5 9.7 0.024 14.5 9.7 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Nup35_RRM PF05172.13 PIK41837.1 - 0.038 14.0 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-H2C2_2 PF13465.6 PIK41837.1 - 0.085 13.3 3.7 2.4 8.7 0.1 3.4 2 1 0 2 2 2 0 Zinc-finger double domain zf-UDP PF14569.6 PIK41837.1 - 0.52 10.5 9.4 0.14 12.3 6.0 1.8 2 0 0 2 2 2 0 Zinc-binding RING-finger FYVE_2 PF02318.16 PIK41837.1 - 2 8.6 8.8 0.46 10.7 3.6 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger SSP160 PF06933.11 PIK41837.1 - 3 5.9 9.7 4.5 5.3 9.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Baculo_IE-1 PF05290.11 PIK41837.1 - 5.9 6.8 13.0 0.76 9.7 7.4 2.3 1 1 2 3 3 3 0 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 PIK41837.1 - 7.2 6.6 15.7 0.47 10.4 4.2 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 TFIIE_beta PF02186.15 PIK41839.1 - 0.084 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 TFIIE beta subunit core domain Adeno_PV PF03910.13 PIK41839.1 - 0.26 10.0 1.2 0.38 9.4 1.2 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV Fic PF02661.18 PIK41840.1 - 3.7e-27 95.1 0.2 1.2e-26 93.5 0.0 1.9 2 1 0 2 2 2 1 Fic/DOC family TPR_2 PF07719.17 PIK41840.1 - 0.00067 19.6 0.4 0.0021 18.0 0.4 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK41840.1 - 0.0012 19.0 0.4 0.006 16.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK41840.1 - 0.0033 18.0 0.0 0.0086 16.7 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41840.1 - 0.0033 17.2 0.1 0.011 15.5 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK41840.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_10 PF13374.6 PIK41840.1 - 0.15 12.0 0.1 4.9 7.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK41840.1 - 0.15 12.9 0.1 0.5 11.3 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PDZ PF00595.24 PIK41841.1 - 8.9e-31 106.1 2.6 4.7e-10 39.7 0.1 3.9 3 1 1 4 4 4 3 PDZ domain PDZ_6 PF17820.1 PIK41841.1 - 9.9e-17 60.5 0.5 3.1e-07 30.1 0.0 3.9 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK41841.1 - 1.1e-12 48.0 0.1 0.00043 20.5 0.0 3.4 3 0 0 3 3 3 3 PDZ domain RVT_1 PF00078.27 PIK41842.1 - 1.3e-29 103.3 0.1 1.7e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sarcoglycan_1 PF04790.13 PIK41844.1 - 0.058 12.7 0.1 0.16 11.3 0.1 1.7 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein zf-C2H2 PF00096.26 PIK41845.1 - 4.5e-15 55.2 24.6 7.1e-06 26.2 4.2 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK41845.1 - 1.5e-12 47.3 22.5 7.3e-05 23.0 0.9 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41845.1 - 6.3e-11 42.2 19.8 0.0013 19.3 2.4 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger C1_4 PF07975.12 PIK41845.1 - 5.8e-07 29.7 6.5 0.0022 18.2 3.1 2.3 2 0 0 2 2 2 2 TFIIH C1-like domain zf-C2HE PF16278.5 PIK41845.1 - 0.0001 22.7 20.4 0.0015 18.9 3.0 3.2 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 PIK41845.1 - 0.00026 20.9 20.9 0.015 15.3 1.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK41845.1 - 0.0014 18.9 10.3 0.029 14.7 0.2 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK41845.1 - 0.02 15.0 20.8 0.093 12.9 2.6 3.7 3 1 1 4 4 4 0 AN1-like Zinc finger zf-met PF12874.7 PIK41845.1 - 0.033 14.6 1.1 0.033 14.6 1.1 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 PIK41845.1 - 0.033 14.1 0.8 0.033 14.1 0.8 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type YhfH PF14149.6 PIK41845.1 - 0.047 13.7 10.5 3.9 7.5 0.0 3.4 3 0 0 3 3 3 0 YhfH-like protein ADK_lid PF05191.14 PIK41845.1 - 0.084 12.9 0.5 0.084 12.9 0.5 2.8 1 1 3 4 4 4 0 Adenylate kinase, active site lid zf-trcl PF13451.6 PIK41845.1 - 0.15 12.0 11.4 6.5 6.7 0.1 3.0 2 1 0 2 2 2 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 PIK41845.1 - 0.18 11.6 16.4 0.66 9.8 2.1 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 PIK41845.1 - 0.21 11.7 18.9 4.9 7.4 4.4 3.3 2 2 1 3 3 3 0 Zinc ribbon domain DUF2072 PF09845.9 PIK41845.1 - 0.27 11.5 0.5 0.27 11.5 0.5 3.0 3 0 0 3 3 3 0 Zn-ribbon containing protein XPA_N PF01286.18 PIK41845.1 - 0.29 11.2 12.3 2.3 8.4 0.7 3.7 4 0 0 4 4 3 0 XPA protein N-terminal FYDLN_acid PF09538.10 PIK41845.1 - 0.45 11.2 3.8 22 5.8 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 PIK41845.1 - 0.5 11.1 9.3 5.2 7.9 9.0 2.2 1 1 0 1 1 1 0 zinc-ribbon family DUF2256 PF10013.9 PIK41845.1 - 0.52 10.5 9.2 0.62 10.2 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Desulfoferrod_N PF06397.12 PIK41845.1 - 0.61 9.8 6.4 32 4.3 0.2 3.3 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain Spt46 PF17734.1 PIK41845.1 - 0.62 9.8 3.9 0.46 10.3 1.6 1.9 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 Fer4_2 PF12797.7 PIK41845.1 - 0.8 9.9 9.0 16 5.9 0.3 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain ADD_ATRX PF17981.1 PIK41845.1 - 0.82 9.6 12.8 6 6.8 5.5 3.0 1 1 2 3 3 3 0 Cysteine Rich ADD domain zf-LYAR PF08790.11 PIK41845.1 - 0.94 9.4 10.9 10 6.1 0.2 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Ribosomal_L37ae PF01780.19 PIK41845.1 - 1.1 9.4 10.7 8.1 6.6 3.5 3.1 1 1 1 2 2 2 0 Ribosomal L37ae protein family HypA PF01155.19 PIK41845.1 - 1.6 8.8 11.8 1.9e+02 2.1 11.8 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 PIK41845.1 - 2.2 8.0 13.3 6.8 6.5 0.2 3.9 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-H2C2_5 PF13909.6 PIK41845.1 - 3.1 7.7 18.0 6.9 6.5 0.1 3.9 3 1 0 3 3 3 0 C2H2-type zinc-finger domain zinc_ribbon_9 PF14369.6 PIK41845.1 - 3.1 8.1 8.3 14 6.0 0.5 3.6 4 0 0 4 4 4 0 zinc-ribbon IBR PF01485.21 PIK41845.1 - 3.4 7.9 19.2 4.6 7.5 2.2 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf_UBZ PF18439.1 PIK41845.1 - 3.4 7.3 11.7 14 5.4 0.4 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger FYVE PF01363.21 PIK41845.1 - 7.1 6.8 19.2 26 5.0 10.6 2.8 1 1 1 2 2 2 0 FYVE zinc finger zinc_ribbon_4 PF13717.6 PIK41845.1 - 7.5 6.6 12.0 17 5.4 0.8 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2 PF00096.26 PIK41846.1 - 8.1e-09 35.5 12.9 0.00032 21.0 2.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK41846.1 - 2.4e-06 27.9 10.7 0.0042 17.8 2.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK41846.1 - 1.2e-05 25.5 0.7 1.2e-05 25.5 0.7 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK41846.1 - 3.8e-05 23.6 6.2 0.00086 19.2 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK41846.1 - 0.0044 17.3 7.2 0.36 11.2 0.8 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK41846.1 - 0.013 15.9 5.8 0.12 12.9 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK41846.1 - 0.013 15.6 1.5 0.038 14.1 1.5 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-Di19 PF05605.12 PIK41846.1 - 0.15 12.4 2.8 0.27 11.6 2.8 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.12 PIK41846.1 - 0.17 12.2 2.2 1.1 9.5 0.1 2.3 1 1 1 2 2 2 0 TFIIH C1-like domain Keratin_matx PF04579.12 PIK41846.1 - 0.25 11.7 4.2 5.4 7.4 0.1 2.6 2 1 1 3 3 3 0 Keratin, high-sulphur matrix protein zf-BED PF02892.15 PIK41846.1 - 0.53 10.4 4.9 2.4 8.3 0.5 2.4 1 1 1 2 2 2 0 BED zinc finger zf-C2HC_2 PF13913.6 PIK41846.1 - 0.78 9.7 7.5 0.26 11.2 0.6 2.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-MYST PF17772.1 PIK41846.1 - 2 8.1 4.7 7.4 6.3 0.4 2.3 1 1 1 2 2 2 0 MYST family zinc finger domain Thioredoxin PF00085.20 PIK41847.1 - 0.0057 16.6 0.0 0.0099 15.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin ELO PF01151.18 PIK41848.1 - 2.3e-64 217.3 24.7 2.7e-64 217.1 24.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family TPR_12 PF13424.6 PIK41849.1 - 7.1e-15 55.1 4.8 4.4e-07 30.1 0.3 4.3 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK41849.1 - 3.9e-07 29.6 13.1 0.008 16.0 0.2 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK41849.1 - 3e-05 23.8 12.4 0.19 11.9 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK41849.1 - 0.0004 20.1 1.2 10 6.1 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat NB-ARC PF00931.22 PIK41849.1 - 0.00048 19.4 0.4 0.0011 18.2 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain TPR_8 PF13181.6 PIK41849.1 - 0.0011 19.0 13.2 0.079 13.2 0.1 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK41849.1 - 0.0083 16.1 0.2 3.2 8.0 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat Radical_SAM PF04055.21 PIK41850.1 - 3.8e-18 66.4 0.0 8e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 PIK41850.1 - 1.3e-09 38.0 0.2 2.3e-09 37.1 0.2 1.5 1 0 0 1 1 1 1 HemN C-terminal domain HTH_45 PF14947.6 PIK41850.1 - 0.019 15.0 0.2 0.46 10.5 0.0 3.1 2 1 1 3 3 3 0 Winged helix-turn-helix HECT PF00632.25 PIK41851.1 - 8e-81 271.9 0.1 1.9e-80 270.7 0.2 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 PIK41851.1 - 1e-63 211.7 27.9 1.7e-12 47.8 0.3 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK41851.1 - 1.1e-33 114.3 43.6 5.8e-10 38.7 0.4 7.6 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat zinc_ribbon_12 PF11331.8 PIK41851.1 - 0.031 14.1 0.2 5.8 6.8 0.0 3.5 3 0 0 3 3 3 0 Probable zinc-ribbon domain V-set PF07686.17 PIK41853.1 - 4.6e-05 23.5 0.2 0.16 12.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41853.1 - 0.0048 17.5 0.3 5 7.8 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41853.1 - 0.039 14.0 0.0 0.33 11.1 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain TssO PF17561.2 PIK41853.1 - 0.04 14.0 0.0 0.069 13.3 0.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO ig PF00047.25 PIK41853.1 - 0.07 13.3 0.0 4.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain PspB PF06667.12 PIK41853.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B Pilin_N PF07790.11 PIK41854.1 - 0.00051 20.9 0.2 0.0024 18.8 0.0 2.2 2 1 0 2 2 2 1 Archaeal Type IV pilin, N-terminal DUF4064 PF13273.6 PIK41854.1 - 0.0035 17.6 0.0 0.0061 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF4448 PF14610.6 PIK41854.1 - 0.0036 17.1 0.1 0.0052 16.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 PIK41854.1 - 0.0089 15.9 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 PIK41854.1 - 0.014 14.8 0.1 0.019 14.4 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF3377 PF11857.8 PIK41854.1 - 0.017 15.0 0.8 0.036 14.0 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF3481 PF11980.8 PIK41854.1 - 0.018 14.7 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein DUF3827 PF12877.7 PIK41854.1 - 0.041 12.3 0.1 0.056 11.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Shisa PF13908.6 PIK41854.1 - 0.041 14.1 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2062 PF09835.9 PIK41854.1 - 0.053 13.4 0.3 0.084 12.7 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) UPF0767 PF15990.5 PIK41854.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 UPF0767 family DUF2897 PF11446.8 PIK41854.1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Myc_target_1 PF15179.6 PIK41854.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Myc target protein 1 SIT PF15330.6 PIK41854.1 - 1.3 9.5 3.3 11 6.5 3.3 2.2 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4519 PF15012.6 PIK41854.1 - 5 7.4 6.3 2.2 8.5 3.8 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4519) DUF3377 PF11857.8 PIK41855.1 - 0.0018 18.1 0.1 0.0032 17.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) DUF4448 PF14610.6 PIK41855.1 - 0.007 16.2 0.1 0.0082 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 PIK41855.1 - 0.016 15.1 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Pilin_N PF07790.11 PIK41855.1 - 0.037 14.9 0.7 0.08 13.9 0.1 1.8 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal DAG1 PF05454.11 PIK41855.1 - 0.042 13.2 0.1 0.053 12.9 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Sigma_reg_N PF13800.6 PIK41855.1 - 0.051 13.9 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3139 PF11337.8 PIK41855.1 - 0.064 13.9 0.3 0.13 12.9 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) COX6C PF02937.15 PIK41855.1 - 0.066 13.3 1.2 0.18 12.0 0.1 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc DUF2207 PF09972.9 PIK41855.1 - 0.13 10.9 0.1 0.16 10.7 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FixS PF03597.15 PIK41855.1 - 1.9 8.2 5.1 3.2 7.5 5.1 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type PH PF00169.29 PIK41856.1 - 5.2e-30 104.1 6.8 1.6e-18 67.1 2.2 2.3 2 0 0 2 2 2 2 PH domain PH_3 PF14593.6 PIK41856.1 - 2.9e-09 37.0 0.9 6.9e-09 35.8 0.9 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK41856.1 - 4.2e-09 36.8 12.1 1.1e-05 25.8 7.5 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 PIK41856.1 - 3.8e-08 33.5 4.1 4.3e-08 33.3 1.0 2.4 2 1 1 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 PIK41856.1 - 0.00012 22.4 1.4 0.00016 22.0 0.4 1.8 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_13 PF16652.5 PIK41856.1 - 0.00036 20.4 0.8 0.0036 17.1 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 PIK41856.1 - 0.00055 19.8 2.4 0.13 12.1 0.1 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 PIK41856.1 - 0.0015 18.8 0.9 0.0073 16.6 0.1 2.5 3 1 0 3 3 3 1 Pleckstrin homology domain Mcp5_PH PF12814.7 PIK41856.1 - 0.018 15.1 1.9 0.42 10.7 1.3 2.7 2 1 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology Sec3-PIP2_bind PF15277.6 PIK41856.1 - 0.037 14.2 0.8 0.1 12.8 0.8 1.8 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH_9 PF15410.6 PIK41856.1 - 0.1 13.0 2.9 0.65 10.4 1.4 2.7 3 1 0 3 3 3 0 Pleckstrin homology domain MyTH4 PF00784.17 PIK41857.1 - 6.5e-11 42.7 0.2 1.6e-10 41.5 0.2 1.6 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 PIK41857.1 - 1.6e-07 31.8 0.1 5.5e-07 30.0 0.1 1.8 1 1 0 1 1 1 1 FERM central domain MoeA_N PF03453.17 PIK41858.1 - 2.8e-46 157.2 1.0 4.9e-46 156.4 1.0 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 PIK41858.1 - 1e-44 151.7 0.7 2.2e-23 82.5 0.0 3.0 3 0 0 3 3 3 2 Probable molybdopterin binding domain MoeA_C PF03454.15 PIK41858.1 - 1.1e-10 41.6 0.0 2.3e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Ras PF00071.22 PIK41859.1 - 1.1e-42 145.4 0.4 7.6e-32 110.2 0.1 2.6 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK41859.1 - 1.6e-16 60.6 0.1 2.1e-08 34.4 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK41859.1 - 5.8e-07 29.1 0.1 0.014 14.9 0.0 3.2 2 1 1 3 3 3 2 ADP-ribosylation factor family VWA_2 PF13519.6 PIK41859.1 - 2e-06 28.4 0.0 0.11 13.2 0.0 2.9 1 1 1 2 2 2 2 von Willebrand factor type A domain zf-Sec23_Sec24 PF04810.15 PIK41859.1 - 1.9e-05 24.6 0.8 4.3e-05 23.5 0.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger RsgA_GTPase PF03193.16 PIK41859.1 - 0.00012 22.0 0.0 0.00031 20.7 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase VWA PF00092.28 PIK41859.1 - 0.0026 18.0 0.1 0.084 13.1 0.0 3.0 2 1 0 2 2 2 1 von Willebrand factor type A domain MMR_HSR1 PF01926.23 PIK41859.1 - 0.011 15.8 0.8 2.5 8.2 0.2 3.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 PIK41859.1 - 0.034 14.4 0.0 0.077 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 PIK41859.1 - 0.056 13.0 0.3 0.36 10.3 0.0 2.3 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain ABC1 PF03109.16 PIK41859.1 - 0.057 13.6 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 ABC1 family PHD PF00628.29 PIK41859.1 - 0.21 11.5 1.5 0.62 10.0 1.5 1.8 1 0 0 1 1 1 0 PHD-finger Ras PF00071.22 PIK41860.1 - 2e-21 76.2 0.1 2.4e-21 76.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41860.1 - 3.7e-10 40.1 0.0 4.3e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK41860.1 - 0.04 13.4 0.0 0.046 13.3 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK41860.1 - 0.085 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family Ras PF00071.22 PIK41861.1 - 2.2e-09 37.1 0.2 6.8e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 PIK41861.1 - 1.3e-06 28.6 0.1 3.1e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase zf-Sec23_Sec24 PF04810.15 PIK41861.1 - 4.1e-06 26.8 0.8 8.2e-06 25.8 0.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger AAA_28 PF13521.6 PIK41861.1 - 0.0015 18.8 0.0 0.0025 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 PIK41861.1 - 0.0078 15.7 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF87 PF01935.17 PIK41861.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 PIK41861.1 - 0.018 15.1 0.2 0.075 13.1 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase PHD PF00628.29 PIK41861.1 - 0.03 14.2 1.7 0.064 13.2 1.7 1.5 1 0 0 1 1 1 0 PHD-finger RsgA_GTPase PF03193.16 PIK41861.1 - 0.079 12.9 0.0 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase LRR_8 PF13855.6 PIK41862.1 - 1.9e-30 104.4 27.5 3.2e-14 52.4 6.2 5.1 2 1 3 5 5 5 4 Leucine rich repeat LRR_5 PF13306.6 PIK41862.1 - 3.9e-11 43.0 0.7 5.1e-07 29.7 0.0 2.3 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK41862.1 - 1.7e-09 37.8 31.4 2e-05 24.9 4.9 5.5 1 1 7 8 8 8 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK41862.1 - 2.4e-05 23.9 5.1 0.0059 16.1 1.1 3.1 2 1 0 3 3 3 2 Leucine-rich repeat EVI2A PF05399.11 PIK41862.1 - 0.0034 17.0 0.0 0.0054 16.4 0.0 1.2 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) HTH_19 PF12844.7 PIK41862.1 - 0.021 14.8 0.1 0.18 11.9 0.1 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain TMEM154 PF15102.6 PIK41862.1 - 0.031 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family LRR_8 PF13855.6 PIK41863.1 - 5.3e-31 106.2 30.2 2.1e-12 46.6 5.9 5.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK41863.1 - 2.5e-14 53.4 0.5 1.4e-08 34.7 0.0 2.4 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK41863.1 - 7.8e-13 48.4 28.9 9.1e-06 25.9 0.6 5.7 1 1 5 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK41863.1 - 1.5e-06 27.8 3.4 0.0099 15.4 0.2 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK41863.1 - 0.11 13.1 27.7 4.6 8.2 0.0 8.1 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK41863.1 - 0.14 12.3 17.6 5.9 7.2 0.1 6.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.7 PIK41864.1 - 3.7e-08 33.5 12.0 9.9e-06 25.8 4.6 2.9 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK41864.1 - 5.3e-08 32.5 10.0 5e-06 26.2 8.1 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 PIK41864.1 - 0.0036 17.6 10.4 0.16 12.6 1.3 3.9 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK41864.1 - 0.55 10.4 10.9 0.26 11.4 2.5 3.0 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 PIK41865.1 - 1.3e-10 40.9 1.2 0.0002 21.1 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK41865.1 - 1.4e-09 38.1 1.0 0.00034 20.9 0.5 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK41865.1 - 9.4e-05 22.5 3.5 3.7 8.5 0.1 4.3 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK41865.1 - 0.0063 16.5 8.3 0.34 11.1 1.5 4.0 5 0 0 5 5 5 2 Leucine Rich repeat TTL PF03133.15 PIK41867.1 - 2e-53 181.5 2.3 3.3e-53 180.7 2.3 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK41867.1 - 0.0031 16.8 0.1 0.011 15.0 0.0 1.9 2 0 0 2 2 2 1 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 PIK41867.1 - 0.062 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DUF5608 PF18356.1 PIK41867.1 - 0.076 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5608) ATPgrasp_ST PF14397.6 PIK41867.1 - 0.16 11.2 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Phage_GP20 PF06810.11 PIK41869.1 - 0.0013 18.6 5.7 0.0019 18.0 5.7 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 UPF0242 PF06785.11 PIK41869.1 - 0.0068 16.5 4.4 0.012 15.8 4.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Taxilin PF09728.9 PIK41869.1 - 0.0074 15.5 6.2 0.13 11.5 0.1 2.1 2 0 0 2 2 2 2 Myosin-like coiled-coil protein ATG16 PF08614.11 PIK41869.1 - 0.028 14.7 14.6 0.99 9.6 14.8 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 PIK41869.1 - 0.073 12.5 9.5 0.11 11.9 9.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 PIK41869.1 - 0.15 11.4 4.2 0.28 10.5 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tropomyosin_1 PF12718.7 PIK41869.1 - 0.18 12.0 9.0 0.44 10.7 0.2 2.3 1 1 1 2 2 2 0 Tropomyosin like Spc7 PF08317.11 PIK41869.1 - 0.23 10.3 6.9 0.4 9.5 6.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 PIK41869.1 - 0.31 11.1 8.2 0.23 11.5 5.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1465 PF07323.12 PIK41869.1 - 0.49 10.2 6.2 4.4 7.1 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) Synaptobrevin PF00957.21 PIK41869.1 - 0.67 9.8 8.3 0.1 12.4 2.8 2.2 1 1 1 2 2 2 0 Synaptobrevin SPATA1_C PF15743.5 PIK41869.1 - 0.69 10.0 6.8 0.7 9.9 5.5 1.6 1 1 0 1 1 1 0 Spermatogenesis-associated C-terminus DUF948 PF06103.11 PIK41869.1 - 0.86 9.9 7.1 1.2 9.4 6.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lebercilin PF15619.6 PIK41869.1 - 1.2 8.8 11.2 0.98 9.0 9.5 1.6 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Csm1_N PF18504.1 PIK41869.1 - 2.7 8.4 11.3 4.5 7.7 3.8 3.1 1 1 2 3 3 3 0 Csm1 N-terminal domain TolA_bind_tri PF16331.5 PIK41869.1 - 3.1 7.9 14.4 17 5.6 4.2 3.3 2 1 2 4 4 4 0 TolA binding protein trimerisation MscS_porin PF12795.7 PIK41869.1 - 4.1 6.9 19.6 31 4.0 19.6 2.0 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain APG6_N PF17675.1 PIK41869.1 - 6.1 7.4 7.6 5.2 7.6 0.6 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region ADIP PF11559.8 PIK41869.1 - 7 6.7 15.5 8.6 6.4 0.7 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding LPP PF04728.13 PIK41869.1 - 7.4 7.0 10.3 15 6.1 0.8 3.7 3 2 0 3 3 3 0 Lipoprotein leucine-zipper DUF724 PF05266.14 PIK41869.1 - 7.5 6.3 7.9 69 3.2 7.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Uso1_p115_C PF04871.13 PIK41869.1 - 8 6.8 9.8 14 6.1 8.4 1.9 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region GTP_EFTU PF00009.27 PIK41870.1 - 3.1e-35 121.5 5.5 1.5e-33 116.0 5.5 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK41870.1 - 8e-13 48.5 0.5 1.4e-12 47.6 0.5 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 PIK41870.1 - 2.1e-07 30.5 0.0 3.2e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK41870.1 - 1.1e-05 25.4 1.2 0.041 13.8 0.2 2.4 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 PIK41870.1 - 0.00011 21.7 0.3 0.00032 20.2 0.3 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK41870.1 - 0.00014 21.5 0.2 0.00022 20.8 0.2 1.3 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 PIK41870.1 - 0.00018 21.1 0.3 0.00066 19.2 0.3 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 PIK41870.1 - 0.00039 20.6 0.2 0.00039 20.6 0.2 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 PIK41870.1 - 0.0041 16.9 0.5 0.01 15.6 0.5 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 PIK41870.1 - 0.007 16.4 0.1 2 8.4 0.0 2.5 1 1 1 2 2 2 1 Dynamin family MMR_HSR1_Xtn PF16897.5 PIK41870.1 - 0.029 14.4 0.2 0.11 12.6 0.2 2.0 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TrmB PF01978.19 PIK41870.1 - 0.034 14.0 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB AAA_26 PF13500.6 PIK41870.1 - 0.041 13.7 0.1 0.068 13.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 PIK41870.1 - 0.68 9.5 3.6 15 5.1 0.3 2.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain EBP PF05241.12 PIK41871.1 - 2.8e-22 79.1 6.2 3.3e-22 78.8 6.2 1.1 1 0 0 1 1 1 1 Emopamil binding protein TIMP PF00965.17 PIK41872.1 - 9.4e-11 41.8 0.0 1.4e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK41872.1 - 4.6e-07 29.6 0.0 6.5e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DSPc PF00782.20 PIK41873.1 - 6.1e-40 136.1 0.0 9.3e-40 135.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK41873.1 - 5.9e-11 42.8 0.0 9e-10 39.0 0.0 2.3 2 0 0 2 2 2 1 Rhodanese-like domain Init_tRNA_PT PF04179.12 PIK41873.1 - 0.00037 20.7 0.0 0.00066 19.9 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 PIK41873.1 - 0.00057 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 PIK41873.1 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ski_Sno PF02437.17 PIK41873.1 - 0.086 12.6 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 SKI/SNO/DAC family LRR_8 PF13855.6 PIK41874.1 - 1.4e-15 56.8 35.1 4.9e-06 26.2 4.4 5.1 3 2 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK41874.1 - 1e-10 41.7 40.6 0.003 17.9 1.5 7.8 3 3 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK41874.1 - 4.8e-07 29.3 37.5 0.059 13.4 0.2 10.7 11 1 1 12 12 12 5 Leucine Rich repeat UBX PF00789.20 PIK41874.1 - 0.0017 18.5 0.1 0.0046 17.1 0.1 1.8 1 0 0 1 1 1 1 UBX domain LRR_1 PF00560.33 PIK41874.1 - 2.5 9.0 17.3 2.8 8.8 0.3 7.0 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK41874.1 - 3.3 7.2 23.1 0.12 11.9 1.2 3.8 3 2 1 4 4 4 0 Leucine-rich repeat COesterase PF00135.28 PIK41875.1 - 2.5e-142 475.3 0.0 2.9e-142 475.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK41875.1 - 2.1e-08 34.3 0.1 6.4e-08 32.7 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK41875.1 - 0.0023 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Adaptin_N PF01602.20 PIK41876.1 - 1.2e-127 426.7 7.1 1.5e-127 426.4 7.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 PIK41876.1 - 2.5e-58 196.5 3.4 5.7e-58 195.4 3.4 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 PIK41876.1 - 2e-38 131.1 0.0 4.2e-38 130.0 0.0 1.6 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 PIK41876.1 - 3.3e-16 59.4 6.1 1.2e-07 32.0 0.1 5.7 3 2 2 6 6 6 3 HEAT repeats Cnd1 PF12717.7 PIK41876.1 - 1.7e-09 38.0 11.2 0.00027 21.0 0.9 4.8 3 1 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 PIK41876.1 - 1.2e-05 25.1 9.5 1.1 9.6 0.1 7.3 7 0 0 7 7 6 1 HEAT repeat HEAT_EZ PF13513.6 PIK41876.1 - 0.00023 21.6 1.7 0.0069 16.9 0.4 4.0 6 0 0 6 6 6 1 HEAT-like repeat Alpha_adaptin_C PF02296.16 PIK41876.1 - 0.00029 21.0 0.0 0.0012 19.1 0.0 2.0 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain B2-adapt-app_C PF09066.10 PIK41876.1 - 0.0011 19.0 0.0 0.0038 17.3 0.0 1.9 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_PBS PF03130.16 PIK41876.1 - 0.059 14.1 3.2 11 7.0 0.1 3.9 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF3385 PF11865.8 PIK41876.1 - 0.12 12.3 1.3 18 5.2 0.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) Fibrinogen_C PF00147.18 PIK41877.1 - 1.2e-47 162.6 3.2 5.3e-45 153.9 3.2 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain NitrOD1 PF18549.1 PIK41877.1 - 0.11 12.5 0.2 0.24 11.4 0.2 1.5 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 Fibrinogen_C PF00147.18 PIK41878.1 - 2.3e-42 145.3 8.1 3e-42 144.9 8.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF5641 PF18701.1 PIK41879.1 - 6.1e-32 109.7 7.3 9.4e-32 109.0 7.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Amidase_6 PF12671.7 PIK41879.1 - 0.072 13.2 0.1 0.098 12.8 0.1 1.1 1 0 0 1 1 1 0 Putative amidase domain Nuc_sug_transp PF04142.15 PIK41881.1 - 2.6e-126 421.0 23.1 2.6e-126 421.0 23.1 1.6 1 1 1 2 2 2 1 Nucleotide-sugar transporter Adaptin_N PF01602.20 PIK41881.1 - 1.3e-25 89.9 2.4 1.9e-25 89.4 2.4 1.2 1 0 0 1 1 1 1 Adaptin N terminal region EamA PF00892.20 PIK41881.1 - 3.3e-06 27.3 34.3 0.0029 17.8 13.4 3.0 2 1 1 3 3 3 2 EamA-like transporter family UAA PF08449.11 PIK41881.1 - 1.4e-05 24.5 5.9 1.4e-05 24.5 5.9 2.7 2 1 0 2 2 2 2 UAA transporter family EmrE PF13536.6 PIK41881.1 - 0.00017 21.3 3.7 0.00017 21.3 3.7 2.7 2 1 1 3 3 3 1 Putative multidrug resistance efflux transporter Cnd1 PF12717.7 PIK41881.1 - 0.032 14.3 0.2 0.061 13.4 0.2 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 PUNUT PF16913.5 PIK41881.1 - 0.79 8.9 26.6 1.5 7.9 25.6 1.8 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport Phage_holin_3_3 PF16083.5 PIK41881.1 - 1.9 8.7 12.2 0.89 9.7 1.2 2.8 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III NACHT PF05729.12 PIK41882.1 - 4.3e-16 59.3 0.0 1.2e-15 57.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK41882.1 - 0.00013 21.3 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK41882.1 - 0.0016 18.7 0.1 0.011 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 PIK41882.1 - 0.059 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sybindin PF04099.12 PIK41882.1 - 0.082 12.8 0.1 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 Sybindin-like family C2-set_2 PF08205.12 PIK41882.1 - 0.17 12.0 0.0 0.51 10.4 0.0 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain SepZ PF06066.11 PIK41883.1 - 0.085 13.1 2.2 0.18 12.0 2.2 1.5 1 0 0 1 1 1 0 SepZ Sulfotransfer_1 PF00685.27 PIK41885.1 - 1.4e-54 185.4 0.6 1.7e-54 185.1 0.6 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK41885.1 - 7.5e-07 29.8 0.1 1.7e-05 25.3 0.1 2.4 2 0 0 2 2 2 1 Sulfotransferase family AAA_25 PF13481.6 PIK41886.1 - 0.00013 21.7 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain C1-set PF07654.15 PIK41886.1 - 0.0011 19.3 1.8 0.073 13.5 0.2 2.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain NACHT PF05729.12 PIK41886.1 - 0.0027 17.6 0.0 0.0074 16.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK41886.1 - 0.035 14.7 0.7 6.5 7.4 0.0 3.2 3 1 0 3 3 3 0 Immunoglobulin domain Peptidase_M56 PF05569.11 PIK41886.1 - 0.087 12.0 0.3 0.15 11.2 0.3 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 V-set PF07686.17 PIK41886.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ribosomal_L30 PF00327.20 PIK41886.1 - 0.11 12.4 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e C2-set_2 PF08205.12 PIK41886.1 - 0.11 12.5 3.1 2 8.6 0.2 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Xan_ur_permease PF00860.20 PIK41888.1 - 3.4e-49 167.6 10.4 4.1e-49 167.3 10.4 1.1 1 0 0 1 1 1 1 Permease family DUF2232 PF09991.9 PIK41888.1 - 4e-05 22.9 0.2 4e-05 22.9 0.2 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2232) Xan_ur_permease PF00860.20 PIK41889.1 - 4.8e-72 242.8 21.6 4.1e-71 239.7 21.8 1.9 2 0 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 PIK41889.1 - 2.7 8.4 15.9 0.83 10.1 2.6 3.8 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily tRNA_bind PF01588.20 PIK41891.1 - 1.6e-15 56.9 0.8 3.1e-15 56.1 0.8 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain ZapB PF06005.12 PIK41891.1 - 0.0011 19.3 5.1 0.0011 19.3 5.1 2.1 2 0 0 2 2 2 1 Cell division protein ZapB HALZ PF02183.18 PIK41891.1 - 0.05 13.8 7.5 0.085 13.1 0.9 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper Fmp27_WPPW PF10359.9 PIK41891.1 - 0.052 12.4 1.1 0.066 12.1 1.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain HTH_53 PF18606.1 PIK41891.1 - 0.14 11.8 0.1 0.4 10.4 0.1 1.7 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain YabA PF06156.13 PIK41891.1 - 0.25 12.0 1.9 0.65 10.7 1.9 1.8 1 1 0 1 1 1 0 Initiation control protein YabA bZIP_1 PF00170.21 PIK41891.1 - 0.68 10.1 6.6 1.6 8.9 0.6 2.6 2 0 0 2 2 2 0 bZIP transcription factor SKA1 PF07160.12 PIK41891.1 - 0.91 9.3 6.0 1.6 8.5 6.0 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 HR1 PF02185.16 PIK41891.1 - 1.3 9.2 8.7 1.3 9.2 4.5 2.6 2 1 1 3 3 3 0 Hr1 repeat Tropomyosin_1 PF12718.7 PIK41891.1 - 2.3 8.3 9.8 0.31 11.2 3.4 2.1 2 0 0 2 2 2 0 Tropomyosin like zf-CSL PF05207.13 PIK41892.1 - 3.1e-23 81.3 1.9 4e-23 80.9 1.9 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 PIK41892.1 - 0.0013 18.8 0.9 0.0023 18.0 0.9 1.4 1 0 0 1 1 1 1 Zinc ribbon domain HSP20 PF00011.21 PIK41893.1 - 1.7e-17 63.4 0.1 2.6e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family zf-C2H2_jaz PF12171.8 PIK41894.1 - 4.1e-07 30.1 1.5 8.4e-07 29.1 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK41894.1 - 9.3e-07 29.0 1.8 2.6e-06 27.6 1.4 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 PIK41894.1 - 0.00017 21.3 1.0 0.00028 20.6 1.0 1.4 1 0 0 1 1 1 1 U1 zinc finger SNRNP27 PF08648.12 PIK41894.1 - 0.0047 17.0 0.4 0.0047 17.0 0.4 2.6 3 1 0 3 3 3 1 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2 PF00096.26 PIK41894.1 - 0.092 13.2 1.4 0.28 11.7 1.0 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type eIF3_subunit PF08597.10 PIK41894.1 - 0.56 10.1 20.4 1.3 8.9 7.0 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Ras PF00071.22 PIK41895.1 - 3.1e-54 182.9 0.0 3.8e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK41895.1 - 3.9e-32 111.0 0.0 5.9e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK41895.1 - 3.6e-15 55.9 0.0 4.8e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK41895.1 - 8.6e-08 31.8 0.9 1.5e-07 31.0 0.0 1.9 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 PIK41895.1 - 2.4e-07 30.3 1.6 1.9e-05 24.0 0.3 3.0 2 1 0 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.27 PIK41895.1 - 6.4e-07 29.1 0.4 2.2e-05 24.1 0.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK41895.1 - 7.3e-07 29.3 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK41895.1 - 8.6e-05 22.0 0.0 0.00015 21.2 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 PIK41895.1 - 0.016 14.6 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 PIK41895.1 - 0.12 11.9 0.0 0.95 9.0 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DLIC PF05783.11 PIK41895.1 - 0.13 11.1 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) WW PF00397.26 PIK41896.1 - 1.8e-08 34.3 4.3 3.2e-08 33.5 4.3 1.5 1 0 0 1 1 1 1 WW domain EF-hand_8 PF13833.6 PIK41896.1 - 0.006 16.4 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair ExbD PF02472.16 PIK41896.1 - 0.016 15.4 1.4 0.041 14.0 0.0 2.2 2 1 0 2 2 2 0 Biopolymer transport protein ExbD/TolR HU-CCDC81_bac_2 PF18175.1 PIK41896.1 - 0.028 14.3 0.1 0.82 9.6 0.1 2.7 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 CCDC144C PF14915.6 PIK41896.1 - 0.035 13.2 4.8 2.9 6.9 1.4 2.4 1 1 0 2 2 2 0 CCDC144C protein coiled-coil region EF-hand_4 PF12763.7 PIK41896.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF5446 PF17522.2 PIK41896.1 - 0.088 13.0 3.8 3.7 7.8 1.3 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5446) PDZ PF00595.24 PIK41897.1 - 1.1e-24 86.6 3.6 1.4e-11 44.6 0.4 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK41897.1 - 3.3e-11 42.8 0.0 8.3e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK41897.1 - 4.1e-08 33.4 0.1 0.013 15.8 0.0 2.3 2 0 0 2 2 2 2 PDZ domain ketoacyl-synt PF00109.26 PIK41898.1 - 2.1e-79 266.7 0.0 2.7e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 PIK41898.1 - 2.3e-07 30.4 0.4 6.7e-07 28.9 0.4 1.7 1 1 1 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 PIK41898.1 - 0.0085 15.9 0.4 0.015 15.1 0.4 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Acyl_transf_1 PF00698.21 PIK41899.1 - 2.8e-62 211.0 0.0 4.9e-62 210.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 PIK41899.1 - 3.3e-40 138.2 0.0 4.9e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 PIK41899.1 - 9.6e-13 48.6 0.0 5.4e-12 46.2 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Toprim_4 PF13662.6 PIK41899.1 - 0.049 14.1 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Toprim domain Sortilin-Vps10 PF15902.5 PIK41899.1 - 0.11 11.3 0.1 0.17 10.6 0.1 1.2 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, KR PF08659.10 PIK41900.1 - 8.5e-46 156.1 0.0 1.8e-45 155.0 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK41900.1 - 8.7e-15 54.7 0.0 2.2e-13 50.1 0.0 3.1 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK41900.1 - 1.7e-07 31.0 0.0 1.1e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 PIK41900.1 - 0.027 13.6 0.0 0.055 12.6 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK41900.1 - 0.083 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK41900.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Thioesterase PF00975.20 PIK41901.1 - 2.8e-27 96.3 0.0 1.3e-26 94.1 0.0 2.0 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 PIK41901.1 - 1.4e-07 31.7 0.5 3e-07 30.7 0.5 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_1 PF00561.20 PIK41901.1 - 1.8e-05 24.5 0.0 0.00021 21.0 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK41901.1 - 0.00018 22.2 0.0 0.00024 21.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK41901.1 - 0.027 13.7 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 7tm_1 PF00001.21 PIK41902.1 - 4.4e-11 42.6 7.8 4.4e-11 42.6 7.8 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Tweety PF04906.13 PIK41902.1 - 0.012 14.3 1.4 0.012 14.3 1.4 2.1 2 0 0 2 2 2 0 Tweety DUF2298 PF10060.9 PIK41902.1 - 0.051 12.3 0.1 0.051 12.3 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) Ndc1_Nup PF09531.10 PIK41902.1 - 1.7 7.2 7.4 2.1 6.9 7.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 7tm_1 PF00001.21 PIK41903.1 - 1.3e-37 129.6 8.0 2e-37 128.9 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LIM PF00412.22 PIK41904.1 - 9.2e-33 112.3 26.3 1.2e-17 63.8 4.1 2.4 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 PIK41904.1 - 9.6e-18 63.8 2.5 1.6e-17 63.1 2.5 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK41904.1 - 0.00026 20.8 0.1 0.00056 19.8 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain DHHC PF01529.20 PIK41905.1 - 4.3e-35 120.7 12.5 4.3e-35 120.7 12.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Comm PF15957.5 PIK41905.1 - 0.051 13.9 8.0 0.094 13.1 0.0 2.7 2 1 1 3 3 3 0 Commissureless FAM176 PF14851.6 PIK41905.1 - 0.13 12.0 0.1 0.13 12.0 0.1 1.6 2 0 0 2 2 2 0 FAM176 family Sushi PF00084.20 PIK41906.1 - 2.4e-22 79.3 26.9 3.7e-09 37.0 1.1 6.5 6 0 0 6 6 6 5 Sushi repeat (SCR repeat) MVL PF12151.8 PIK41906.1 - 0.21 11.5 0.1 0.21 11.5 0.1 3.2 4 0 0 4 4 4 0 Mannan-binding protein Sushi PF00084.20 PIK41907.1 - 0.0038 17.8 0.3 0.021 15.4 0.1 2.3 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Ig_2 PF13895.6 PIK41907.1 - 0.011 16.0 0.1 0.048 14.0 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK41907.1 - 0.033 14.8 0.1 0.2 12.2 0.1 2.1 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK41907.1 - 0.069 13.3 0.5 0.3 11.3 0.2 2.1 2 1 0 2 2 2 0 Immunoglobulin domain Arf PF00025.21 PIK41908.1 - 4.3e-79 264.0 0.1 4.8e-79 263.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK41908.1 - 2.6e-14 53.5 0.0 3.5e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK41908.1 - 1.6e-13 50.5 0.0 2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK41908.1 - 1.1e-12 47.9 0.0 1.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 PIK41908.1 - 1.3e-12 47.5 1.3 1.4e-08 34.3 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 PIK41908.1 - 1.9e-11 43.8 0.0 2.3e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK41908.1 - 3e-06 27.3 0.0 4.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK41908.1 - 0.0039 16.5 0.9 0.012 14.9 0.9 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase NACHT PF05729.12 PIK41908.1 - 0.036 14.0 0.5 0.084 12.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 PIK41908.1 - 0.094 12.3 0.2 0.65 9.6 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GRP PF07172.11 PIK41909.1 - 0.0013 19.4 2.1 0.0013 19.4 2.1 2.7 3 0 0 3 3 3 1 Glycine rich protein family DUF4203 PF13886.6 PIK41911.1 - 8.1e-35 120.3 24.8 8.1e-35 120.3 24.8 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) BRI3BP PF14965.6 PIK41911.1 - 0.49 9.9 7.6 0.83 9.1 7.0 1.7 1 1 0 1 1 1 0 Negative regulator of p53/TP53 Phage_holin_5_2 PF16079.5 PIK41911.1 - 0.7 10.3 13.3 2 8.8 2.8 2.9 1 1 2 3 3 3 0 Phage holin family Hol44, in holin superfamily V BRCT PF00533.26 PIK41914.1 - 1.4e-08 35.0 0.1 0.0089 16.4 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK41914.1 - 5.2e-07 30.0 0.1 0.027 14.9 0.0 2.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK41914.1 - 0.002 17.9 0.0 0.01 15.7 0.0 2.1 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 PIK41914.1 - 0.067 13.3 0.1 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain RRM_1 PF00076.22 PIK41916.1 - 6.4e-07 29.1 0.0 0.00035 20.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK41916.1 - 0.16 11.9 0.0 0.62 10.0 0.0 2.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif CUB PF00431.20 PIK41918.1 - 1.2e-26 93.2 0.0 4.5e-18 65.6 0.1 2.6 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.18 PIK41918.1 - 2.8e-21 75.4 49.9 1.5e-12 47.5 11.0 7.1 7 1 1 8 8 8 4 Low-density lipoprotein receptor domain class A Cyt-b5 PF00173.28 PIK41919.1 - 1.7e-09 37.7 0.0 2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Anoctamin PF04547.12 PIK41920.1 - 1.2e-86 291.3 6.8 2.3e-86 290.5 6.8 1.4 1 1 0 1 1 1 1 Calcium-activated chloride channel DUF2207 PF09972.9 PIK41920.1 - 0.037 12.8 7.7 0.12 11.2 1.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ribosomal_L13e PF01294.18 PIK41921.1 - 3e-77 258.5 4.8 4.5e-77 258.0 4.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e tRNA-synt_1 PF00133.22 PIK41922.1 - 4.6e-26 91.2 5.1 9.1e-19 67.1 1.1 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 PIK41922.1 - 1.3e-20 73.5 0.1 4.3e-18 65.2 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 PIK41922.1 - 3.9e-20 72.2 0.0 8.1e-20 71.1 0.0 1.5 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 AMP-binding PF00501.28 PIK41923.1 - 2.5e-59 201.0 0.0 4.2e-59 200.2 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK41923.1 - 8.4e-16 58.7 0.0 1.8e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain fn3 PF00041.21 PIK41924.1 - 7.7e-19 67.8 6.6 8.6e-09 35.6 0.3 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK41924.1 - 4e-05 24.1 10.0 0.06 13.9 3.1 2.7 2 2 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK41924.1 - 0.00052 20.3 0.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 PIK41924.1 - 0.32 11.2 2.2 12 6.2 0.8 2.6 2 2 0 2 2 2 0 Fibronectin type III domain CHB_HEX_C_1 PF13290.6 PIK41924.1 - 2.4 8.2 9.2 6.5 6.8 7.1 2.8 2 1 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain hEGF PF12661.7 PIK41925.1 - 0.00045 20.8 8.1 0.00045 20.8 8.1 4.6 5 0 0 5 5 5 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK41925.1 - 0.00074 19.8 15.6 0.00074 19.8 15.6 3.5 3 1 0 3 3 3 2 EGF-like domain EGF PF00008.27 PIK41925.1 - 0.022 15.0 10.0 0.022 15.0 10.0 4.1 3 2 1 4 4 4 0 EGF-like domain fn3 PF00041.21 PIK41926.1 - 9.7e-12 45.1 0.3 7.7e-07 29.4 0.1 2.8 2 1 0 2 2 2 2 Fibronectin type III domain fn3_4 PF16794.5 PIK41926.1 - 0.00081 19.3 0.0 0.038 13.9 0.0 2.7 2 0 0 2 2 2 1 Fibronectin-III type domain Pur_ac_phosph_N PF16656.5 PIK41926.1 - 0.0018 18.8 0.0 0.062 13.9 0.0 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 PIK41926.1 - 0.0019 18.8 0.3 2.1 9.0 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain hEGF PF12661.7 PIK41926.1 - 0.014 16.0 7.6 0.014 16.0 7.6 6.4 5 1 0 5 5 5 0 Human growth factor-like EGF DUF4945 PF16303.5 PIK41926.1 - 0.027 14.4 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) RVT_1 PF00078.27 PIK41927.1 - 0.016 14.8 0.1 0.034 13.6 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) CTD_bind PF04818.13 PIK41927.1 - 0.039 14.8 1.2 16 6.4 0.1 3.5 2 1 0 2 2 2 0 RNA polymerase II-binding domain. DUF4738 PF15889.5 PIK41927.1 - 0.074 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4738) FANCI_S2 PF14676.6 PIK41927.1 - 0.082 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 FANCI solenoid 2 fn3 PF00041.21 PIK41928.1 - 4.2e-14 52.6 0.4 2.8e-08 34.0 0.2 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Mem_trans PF03547.18 PIK41928.1 - 0.00093 17.7 0.0 0.38 9.1 0.1 2.1 1 1 1 2 2 2 2 Membrane transport protein TMEM154 PF15102.6 PIK41928.1 - 0.0014 18.6 0.0 0.0032 17.4 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family Pur_ac_phosph_N PF16656.5 PIK41928.1 - 0.0019 18.8 0.5 0.056 14.0 0.4 2.7 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 PIK41928.1 - 0.002 18.0 0.0 0.2 11.6 0.0 2.4 2 0 0 2 2 2 1 Fibronectin-III type domain Ninjurin PF04923.12 PIK41928.1 - 0.009 15.9 1.3 0.078 12.9 0.1 2.2 2 0 0 2 2 2 1 Ninjurin SIT PF15330.6 PIK41928.1 - 0.015 15.8 0.1 0.033 14.6 0.1 1.7 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 PIK41928.1 - 0.027 15.4 0.0 0.053 14.4 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LRR19-TM PF15176.6 PIK41928.1 - 0.028 14.4 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF4083 PF13314.6 PIK41928.1 - 0.065 13.2 0.3 0.18 11.8 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Saf_2TM PF18303.1 PIK41928.1 - 0.076 12.6 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Sigma_reg_N PF13800.6 PIK41928.1 - 0.077 13.3 0.1 0.31 11.3 0.0 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal tRNA_anti-like PF12869.7 PIK41928.1 - 0.12 12.0 0.8 0.31 10.6 0.1 2.0 2 1 0 2 2 2 0 tRNA_anti-like OAD_gamma PF04277.13 PIK41928.1 - 0.16 12.6 0.0 0.42 11.2 0.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain fn3 PF00041.21 PIK41929.1 - 7.5e-17 61.5 0.6 2.8e-07 30.8 0.2 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK41929.1 - 0.00031 21.3 0.3 0.018 15.6 0.2 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 PIK41929.1 - 0.0012 18.7 0.0 0.046 13.6 0.0 2.5 2 0 0 2 2 2 1 Fibronectin-III type domain hEGF PF12661.7 PIK41929.1 - 0.011 16.3 7.3 0.011 16.3 7.3 7.2 6 1 0 6 6 6 0 Human growth factor-like EGF fn3_2 PF16893.5 PIK41929.1 - 0.09 12.9 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III domain RVT_1 PF00078.27 PIK41930.1 - 5e-22 78.5 0.0 8.3e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK41930.1 - 2.3e-06 27.8 0.2 4.5e-05 23.7 0.3 2.8 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41930.1 - 0.00037 20.5 0.2 0.0055 16.7 0.3 2.5 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Phage_integrase PF00589.22 PIK41932.1 - 0.0084 15.9 0.0 0.033 14.0 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family Ank_4 PF13637.6 PIK41933.1 - 1.5e-14 54.2 0.3 7.2e-08 32.8 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK41933.1 - 1.8e-14 54.1 0.0 4.7e-14 52.7 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK41933.1 - 8.7e-14 50.3 0.0 2.8e-05 24.1 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 PIK41933.1 - 1.4e-13 50.6 0.0 9.8e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 PIK41933.1 - 1.8e-12 47.2 0.0 2.6e-06 27.6 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF1421 PF07223.11 PIK41935.1 - 0.00052 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain (DUF1421) Baculo_PEP_C PF04513.12 PIK41935.1 - 3.3 7.7 10.0 3.9 7.5 2.6 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.15 PIK41936.1 - 0.0041 17.6 28.4 0.0041 17.6 28.4 6.1 1 1 3 4 4 4 1 Fez1 PTSIIA_gutA PF03829.13 PIK41936.1 - 0.028 14.3 17.1 31 4.5 0.1 6.5 1 1 6 7 7 7 0 PTS system glucitol/sorbitol-specific IIA component Yae1_N PF09811.9 PIK41936.1 - 2 8.2 25.3 30 4.4 0.1 9.2 4 4 3 11 11 11 0 Essential protein Yae1, N terminal EF-hand_7 PF13499.6 PIK41937.1 - 7.5e-10 39.1 1.7 7.5e-10 39.1 1.7 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK41937.1 - 1.6e-09 36.6 7.5 6.5e-05 22.2 1.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK41937.1 - 8.5e-08 31.5 5.7 0.00034 20.3 0.2 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 PIK41937.1 - 2.3e-06 27.3 7.9 0.0026 17.6 0.4 3.3 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK41937.1 - 0.018 15.3 0.2 0.036 14.4 0.2 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Homez PF11569.8 PIK41937.1 - 0.027 13.9 0.0 0.052 13.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Rnk_N PF14760.6 PIK41937.1 - 0.17 12.4 0.6 6.2 7.4 0.1 2.5 2 0 0 2 2 2 0 Rnk N-terminus POTRA_2 PF08479.11 PIK41937.1 - 0.23 11.3 0.0 0.52 10.2 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type EF-hand_5 PF13202.6 PIK41937.1 - 0.29 10.7 6.7 3.7 7.2 1.4 2.6 2 0 0 2 2 2 0 EF hand AMP-binding PF00501.28 PIK41938.1 - 7.4e-100 334.5 0.0 9.3e-100 334.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cache_3-Cache_2 PF17201.4 PIK41938.1 - 0.024 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain RPGR1_C PF18111.1 PIK41938.1 - 0.2 11.6 0.5 4.9 7.0 0.1 2.2 2 0 0 2 2 2 0 Retinitis pigmentosa G-protein regulator interacting C-terminal Glyco_hydro_1 PF00232.18 PIK41940.1 - 9e-153 508.9 4.6 9.8e-108 360.5 0.9 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 1 Cellulase PF00150.18 PIK41940.1 - 0.0046 16.4 0.8 0.83 9.0 0.1 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_10 PF00331.20 PIK41940.1 - 0.062 12.4 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 RNase_PH PF01138.21 PIK41941.1 - 4.8e-23 82.1 0.5 4.8e-23 82.1 0.5 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK41941.1 - 1.1e-05 25.4 0.2 3.8e-05 23.6 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RrnaAD PF00398.20 PIK41942.1 - 1e-15 57.5 0.0 1.3e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF2838 PF10998.8 PIK41942.1 - 0.12 12.6 0.2 0.36 11.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) Methyltransf_25 PF13649.6 PIK41942.1 - 0.16 12.7 0.0 0.42 11.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain CDC45 PF02724.14 PIK41944.1 - 0.031 12.6 15.7 0.036 12.4 15.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 PIK41944.1 - 0.48 8.6 20.4 0.54 8.4 20.4 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2151 PF10221.9 PIK41944.1 - 4.7 5.7 9.6 5.3 5.5 9.6 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF1759 PF03564.15 PIK41945.1 - 4.3e-09 36.5 0.0 3.1e-08 33.7 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1759) FtsA PF14450.6 PIK41945.1 - 0.034 14.5 0.0 0.075 13.5 0.0 1.6 1 1 1 2 2 2 0 Cell division protein FtsA RT_RNaseH PF17917.1 PIK41946.1 - 1.6e-36 124.8 0.0 3.5e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK41946.1 - 6e-33 112.9 0.0 1.2e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK41946.1 - 2.3e-14 53.5 0.0 3.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK41947.1 - 1.5e-21 76.3 1.3 3.1e-21 75.2 1.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK41947.1 - 9e-13 48.5 0.0 4.7e-12 46.1 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK41947.1 - 6.5e-05 23.1 0.4 6.5e-05 23.1 0.4 1.9 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK41947.1 - 0.0017 18.1 0.4 0.057 13.2 0.0 2.7 2 1 1 3 3 3 1 Integrase core domain Imm25 PF15564.6 PIK41949.1 - 0.04 13.8 0.2 0.065 13.2 0.2 1.3 1 0 0 1 1 1 0 Immunity protein 25 Pkinase_Tyr PF07714.17 PIK41951.1 - 3.7e-21 75.6 0.0 5.5e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK41951.1 - 6.1e-11 42.2 0.0 1.1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK41951.1 - 2.7e-05 24.7 5.3 0.014 15.9 1.5 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41951.1 - 0.00047 20.4 2.6 0.091 13.1 1.6 2.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK41951.1 - 0.00079 19.6 2.6 0.019 15.1 1.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK41951.1 - 0.0033 17.5 0.2 0.0097 16.0 0.2 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 PIK41951.1 - 0.021 15.0 2.0 0.61 10.3 0.1 2.5 1 1 1 2 2 2 0 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK41951.1 - 0.036 14.0 0.5 0.072 13.0 0.5 1.4 1 0 0 1 1 1 0 TMEM154 protein family Ig_5 PF16681.5 PIK41951.1 - 0.04 14.3 2.1 0.34 11.3 1.4 2.6 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK41951.1 - 0.09 12.9 2.3 0.23 11.5 2.3 1.7 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK41951.1 - 0.19 12.1 3.8 1.4 9.4 0.1 3.4 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK41951.1 - 0.25 11.6 7.0 1.6 9.1 5.4 2.7 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK41952.1 - 1.6e-08 34.7 4.5 0.0048 17.0 0.2 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK41952.1 - 1.1e-07 32.4 3.1 0.12 13.0 0.1 3.8 3 0 0 3 3 3 2 Immunoglobulin domain NHL PF01436.21 PIK41952.1 - 4.9e-06 26.3 0.0 7.9 6.7 0.0 5.1 5 0 0 5 5 5 2 NHL repeat ig PF00047.25 PIK41952.1 - 7.3e-05 22.9 2.3 0.08 13.1 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41952.1 - 0.00025 21.1 1.6 1.2 9.2 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin I-set domain SGL PF08450.12 PIK41952.1 - 0.0018 17.9 0.0 0.099 12.2 0.0 3.2 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Ig_2 PF13895.6 PIK41952.1 - 0.035 14.4 2.6 4 7.8 0.1 3.1 3 0 0 3 3 3 0 Immunoglobulin domain SBBP PF06739.11 PIK41952.1 - 0.049 13.6 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Beta-propeller repeat C2-set_2 PF08205.12 PIK41952.1 - 0.099 12.7 0.1 0.38 10.8 0.1 2.0 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain HPIP PF15226.6 PIK41952.1 - 0.21 12.0 0.0 0.38 11.2 0.0 1.4 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family Death PF00531.22 PIK41955.1 - 2.2e-09 37.3 2.8 2.7e-09 37.0 1.5 1.8 2 0 0 2 2 2 1 Death domain SH2 PF00017.24 PIK41955.1 - 0.011 15.9 0.1 0.023 14.8 0.1 1.6 1 0 0 1 1 1 0 SH2 domain NACHT PF05729.12 PIK41956.1 - 8.4e-10 38.8 0.0 8.5e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 NACHT domain Ig_3 PF13927.6 PIK41956.1 - 2.8e-09 37.5 2.5 0.0055 17.3 0.0 6.0 5 1 1 6 6 6 1 Immunoglobulin domain V-set PF07686.17 PIK41956.1 - 2.7e-06 27.5 0.1 0.00094 19.3 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK41956.1 - 0.00011 22.3 1.6 0.064 13.4 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK41956.1 - 0.00025 21.0 0.8 0.64 10.1 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK41956.1 - 0.00084 19.6 1.2 3.5 8.0 0.0 4.4 4 1 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK41956.1 - 0.0091 16.0 0.4 0.46 10.6 0.0 3.6 4 1 1 5 5 5 1 Immunoglobulin I-set domain AAA_25 PF13481.6 PIK41956.1 - 0.11 12.1 0.0 0.45 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.17 PIK41957.1 - 7.2e-23 81.2 0.1 1.2e-22 80.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 PIK41957.1 - 7.3e-20 70.8 0.2 2.1e-07 30.9 0.1 3.5 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK41957.1 - 5.7e-18 65.3 4.7 0.00012 22.6 0.1 4.6 4 1 0 4 4 4 3 Immunoglobulin domain Pkinase PF00069.25 PIK41957.1 - 6.5e-17 61.8 0.2 1e-16 61.1 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK41957.1 - 2.3e-12 47.1 1.2 0.0019 18.5 0.1 4.7 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK41957.1 - 1.6e-10 40.9 0.1 0.093 12.8 0.0 4.6 5 0 0 5 5 5 3 Immunoglobulin I-set domain C1-set PF07654.15 PIK41957.1 - 6.2e-10 39.3 0.1 0.00042 20.6 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain ig PF00047.25 PIK41957.1 - 1.6e-06 28.2 1.6 5.2 7.3 0.1 5.6 5 1 0 5 5 5 2 Immunoglobulin domain DUF2111 PF09884.9 PIK41957.1 - 0.0057 16.7 0.1 3.3 7.9 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2111) V-set PF07686.17 PIK41957.1 - 0.014 15.5 0.9 2.8 8.2 0.1 4.1 4 1 0 4 4 4 0 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK41957.1 - 0.098 12.2 0.0 0.32 10.6 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain RVT_1 PF00078.27 PIK41958.1 - 4.5e-31 108.1 0.0 5.5e-31 107.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Death PF00531.22 PIK41959.1 - 1.9e-13 50.4 1.0 6.9e-13 48.6 0.3 2.1 3 0 0 3 3 3 1 Death domain DED PF01335.21 PIK41959.1 - 1e-09 38.5 0.2 2.2e-08 34.3 0.1 2.3 2 0 0 2 2 2 1 Death effector domain RVT_1 PF00078.27 PIK41960.1 - 4.9e-24 85.1 0.1 6.3e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IF-2B PF01008.17 PIK41961.1 - 1.1e-80 270.9 0.0 1.2e-80 270.7 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ig_3 PF13927.6 PIK41962.1 - 4.4e-62 206.7 0.0 5.4e-13 49.3 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK41962.1 - 4e-59 196.7 0.0 2.9e-16 59.3 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.25 PIK41962.1 - 2.4e-42 143.0 0.0 5.9e-10 39.2 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 PIK41962.1 - 1.9e-39 133.9 0.0 2.1e-08 34.3 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 PIK41962.1 - 3.9e-19 68.8 8.6 0.038 14.1 0.0 9.4 5 5 2 7 7 7 5 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK41962.1 - 2.4e-11 43.0 0.0 0.13 11.9 0.0 5.0 5 0 0 5 5 5 3 Immunoglobulin domain Ig_5 PF16681.5 PIK41962.1 - 4.2e-10 39.9 0.0 0.026 14.9 0.0 5.4 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK41962.1 - 3.1e-06 27.1 0.0 1.2 9.2 0.0 5.2 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK41962.1 - 1.7e-05 24.8 0.1 4 7.6 0.0 5.1 5 1 1 6 6 6 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK41962.1 - 7.6e-05 22.9 1.0 13 6.1 0.0 6.2 6 2 1 7 7 7 1 T-cell surface glycoprotein CD3 delta chain BiPBP_C PF06832.12 PIK41962.1 - 0.00055 19.9 0.0 0.84 9.7 0.0 3.6 4 0 0 4 4 4 1 Penicillin-Binding Protein C-terminus Family DUF4448 PF14610.6 PIK41962.1 - 0.091 12.5 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Ig_3 PF13927.6 PIK41963.1 - 5.8e-10 39.6 2.9 3.8e-08 33.8 0.3 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK41963.1 - 2.2e-08 34.3 1.7 4.4e-06 26.9 0.2 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK41963.1 - 9e-08 32.1 0.1 1.3e-05 25.1 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK41963.1 - 1.4e-07 31.5 2.4 3.1e-07 30.5 0.3 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK41963.1 - 0.0019 18.4 2.5 0.045 13.9 0.6 2.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK41963.1 - 0.0038 17.2 0.1 0.04 14.0 0.0 2.2 2 1 0 2 2 2 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 PIK41963.1 - 0.042 13.8 0.2 0.15 12.0 0.0 1.9 1 1 1 2 2 2 0 CD47 immunoglobulin-like domain Esterase_phd PF10503.9 PIK41964.1 - 2.8e-13 49.9 1.5 4.9e-07 29.5 0.1 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Porin_3 PF01459.22 PIK41965.1 - 4.1e-43 147.8 0.2 5.2e-43 147.5 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin AMOP PF03782.17 PIK41966.1 - 1.8e-37 128.6 7.6 3.1e-37 127.9 7.6 1.4 1 0 0 1 1 1 1 AMOP domain NIDO PF06119.14 PIK41966.1 - 2.4e-19 70.1 0.2 6.8e-19 68.6 0.2 1.9 1 0 0 1 1 1 1 Nidogen-like VWD PF00094.25 PIK41966.1 - 4.4e-19 69.3 0.0 7.9e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain Sushi PF00084.20 PIK41966.1 - 1.9e-11 44.4 6.0 4.3e-06 27.2 0.8 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) zf-C2H2 PF00096.26 PIK41967.1 - 6.9e-05 23.1 9.5 0.049 14.1 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK41967.1 - 0.00084 19.0 3.8 0.00084 19.0 3.8 2.3 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 PIK41967.1 - 0.0049 17.1 5.5 0.19 12.0 1.4 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK41967.1 - 0.036 14.4 3.7 0.036 14.4 3.7 1.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK41967.1 - 0.055 13.9 2.3 0.055 13.9 2.3 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK41967.1 - 0.063 14.2 8.8 0.93 10.5 0.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Actin_micro PF17003.5 PIK41967.1 - 0.3 10.2 6.6 0.29 10.2 5.1 1.6 1 1 1 2 2 2 0 Putative actin-like family AMOP PF03782.17 PIK41968.1 - 2.4e-13 50.4 1.9 3.6e-13 49.8 1.9 1.2 1 0 0 1 1 1 1 AMOP domain Sulfotransfer_1 PF00685.27 PIK41969.1 - 3.3e-07 30.0 0.0 7.3e-07 28.9 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK41969.1 - 2.6e-06 28.0 0.0 0.00086 19.7 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family Lectin_C PF00059.21 PIK41971.1 - 1.5e-13 51.4 0.1 2.2e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK41971.1 - 0.0034 17.0 0.0 0.014 15.1 0.0 1.8 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like CEP19 PF14933.6 PIK41972.1 - 0.025 14.9 2.4 0.026 14.8 2.4 1.0 1 0 0 1 1 1 0 CEP19-like protein LRR19-TM PF15176.6 PIK41972.1 - 0.64 10.0 3.1 0.94 9.5 3.1 1.5 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain GST_C_3 PF14497.6 PIK41973.1 - 4.9e-21 74.8 0.0 6.5e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK41973.1 - 1.5e-10 41.1 0.0 2.3e-10 40.5 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK41973.1 - 2e-05 24.5 0.0 4.2e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK41973.1 - 0.099 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK41974.1 - 1.6e-19 69.9 0.0 1.8e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK41974.1 - 6.4e-09 35.9 0.0 8.1e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK41974.1 - 2e-07 30.9 0.0 3.7e-07 30.1 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Nup35_RRM PF05172.13 PIK41976.1 - 2.5e-24 85.2 0.0 4.4e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 PIK41976.1 - 1.4e-10 41.0 0.0 2.1e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif NACHT PF05729.12 PIK41980.1 - 2.4e-11 43.9 0.0 8.3e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK41980.1 - 0.023 14.2 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK41980.1 - 0.055 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain PEP_hydrolase PF09370.10 PIK41980.1 - 0.2 10.9 0.0 0.86 8.8 0.0 1.9 1 1 1 2 2 2 0 Phosphoenolpyruvate hydrolase-like Dor1 PF04124.12 PIK41981.1 - 1.7e-75 253.8 4.5 2.1e-75 253.5 4.5 1.0 1 0 0 1 1 1 1 Dor1-like family Sec5 PF15469.6 PIK41981.1 - 0.061 13.1 1.0 0.37 10.6 0.5 2.0 1 1 1 2 2 2 0 Exocyst complex component Sec5 DUF2076 PF09849.9 PIK41982.1 - 2.4 8.2 11.3 4.1 7.4 11.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-H2C2_2 PF13465.6 PIK41985.1 - 7.1e-14 51.5 24.1 1.5e-09 37.9 0.8 5.2 5 1 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK41985.1 - 2.1e-12 46.8 30.3 0.00048 20.4 3.9 5.4 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK41985.1 - 5.1e-10 39.3 32.6 0.0014 19.3 1.1 5.4 6 0 0 6 6 5 3 C2H2-type zinc finger HalOD2 PF18547.1 PIK41985.1 - 7.4e-06 25.8 2.6 8.7e-05 22.3 2.6 2.3 1 1 0 1 1 1 1 Halobacterial output domain 2 zf-C2H2_6 PF13912.6 PIK41985.1 - 0.00039 20.3 0.4 0.00039 20.3 0.4 3.9 4 0 0 4 4 3 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK41985.1 - 0.00097 19.8 12.6 0.02 15.6 2.5 2.8 2 1 1 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 PIK41985.1 - 0.0033 17.7 16.4 0.0082 16.4 0.6 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 PIK41985.1 - 0.017 14.7 17.9 0.32 10.6 0.9 4.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger FYVE PF01363.21 PIK41985.1 - 0.066 13.4 18.1 0.059 13.5 9.9 2.5 1 1 1 2 2 2 0 FYVE zinc finger Rubredoxin_2 PF18073.1 PIK41985.1 - 0.13 12.0 7.0 3.7 7.4 0.2 3.0 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-H2C2_5 PF13909.6 PIK41985.1 - 0.18 11.6 0.2 0.18 11.6 0.2 5.3 8 0 0 8 8 5 0 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.10 PIK41985.1 - 0.22 11.7 15.5 0.54 10.4 0.6 4.3 3 1 1 4 4 4 0 Zinc ribbon domain zf-met PF12874.7 PIK41985.1 - 0.33 11.4 24.3 0.94 10.0 0.4 4.5 4 1 0 4 4 4 0 Zinc-finger of C2H2 type DUF2256 PF10013.9 PIK41985.1 - 0.41 10.8 4.7 5.8 7.1 0.2 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-LYAR PF08790.11 PIK41985.1 - 1.9 8.5 15.2 3.6 7.6 0.9 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.5 PIK41985.1 - 2.2 9.1 14.3 3.5 8.4 3.7 2.8 1 1 3 4 4 4 0 zinc-ribbon family C1_1 PF00130.22 PIK41985.1 - 3 7.8 13.0 28 4.7 9.6 3.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FUR PF01475.19 PIK41985.1 - 3.3 7.9 6.7 0.52 10.5 1.7 2.1 2 1 0 2 2 2 0 Ferric uptake regulator family TF_Zn_Ribbon PF08271.12 PIK41985.1 - 3.5 7.2 8.0 2.1 7.9 3.6 2.8 2 1 0 2 2 2 0 TFIIB zinc-binding CxC3 PF18804.1 PIK41985.1 - 4.2 7.3 8.4 1.6 8.6 2.4 2.4 1 1 1 2 2 2 0 CxC3 like cysteine cluster associated with KDZ transposases XPA_N PF01286.18 PIK41985.1 - 4.5 7.4 12.3 29 4.8 0.1 4.2 4 0 0 4 4 4 0 XPA protein N-terminal PDE4_UCR PF18100.1 PIK41986.1 - 0.52 11.0 6.8 0.3 11.7 0.4 2.9 3 0 0 3 3 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) PRC2_HTH_1 PF18118.1 PIK41986.1 - 1.1 10.1 9.5 0.056 14.3 2.7 2.3 2 1 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain DnaJ PF00226.31 PIK41986.1 - 1.7 8.8 5.4 0.24 11.6 0.4 2.2 2 1 0 2 2 2 0 DnaJ domain CoA_transf_3 PF02515.17 PIK41986.1 - 5.2 6.1 5.6 2.8 6.9 1.4 2.3 2 1 1 3 3 3 0 CoA-transferase family III Vitellogenin_N PF01347.22 PIK41987.1 - 3.9e-09 35.5 0.8 7.5e-09 34.5 0.8 1.4 1 1 0 1 1 1 1 Lipoprotein amino terminal region HEAT_2 PF13646.6 PIK41987.1 - 5.8e-05 23.4 0.3 0.01 16.2 0.0 2.5 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 PIK41987.1 - 0.065 13.5 0.1 17 6.0 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat CTK3 PF12243.8 PIK41987.1 - 0.087 12.8 0.9 1.5 8.8 0.1 2.4 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 HEAT_EZ PF13513.6 PIK41987.1 - 0.12 12.9 0.2 1.2 9.7 0.1 2.7 3 0 0 3 3 3 0 HEAT-like repeat DUF4595 PF15283.6 PIK41988.1 - 0.041 13.9 0.1 0.044 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold DUF2812 PF11193.8 PIK41988.1 - 0.076 13.2 0.5 0.097 12.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2812) tRNA_m1G_MT PF01746.21 PIK41989.1 - 1.2e-30 106.7 0.0 2e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF3918 PF13056.6 PIK41989.1 - 3.1 7.5 5.5 6.9 6.4 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) SPATIAL PF15256.6 PIK41990.1 - 4.4e-13 50.0 0.2 6.3e-13 49.5 0.2 1.2 1 0 0 1 1 1 1 SPATIAL C2 PF00168.30 PIK41991.1 - 1.4e-19 70.2 0.1 6e-10 39.3 0.0 2.2 2 0 0 2 2 2 2 C2 domain 7tm_2 PF00002.24 PIK41992.1 - 1.6e-17 63.7 7.4 2.2e-17 63.2 7.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK41992.1 - 5.4e-13 49.2 2.8 9.5e-13 48.5 2.8 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif VESA1_N PF12785.7 PIK41992.1 - 0.067 12.2 0.6 0.096 11.6 0.6 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 HD PF01966.22 PIK41994.1 - 3.7e-07 30.4 0.0 6.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 HD domain Phage_hub_GP28 PF11110.8 PIK41994.1 - 0.057 13.3 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 Baseplate hub distal subunit Prok-RING_1 PF14446.6 PIK41995.1 - 0.0093 15.9 4.3 1.3 9.0 0.1 2.8 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 THOC7 PF05615.13 PIK41996.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 HD PF01966.22 PIK41997.1 - 4.4e-14 52.8 0.1 1.2e-13 51.4 0.1 1.8 1 0 0 1 1 1 1 HD domain SH3_2 PF07653.17 PIK41997.1 - 5.3e-06 26.0 0.0 1.6e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK41997.1 - 0.00019 21.2 0.0 0.00042 20.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PDEase_I PF00233.19 PIK41997.1 - 0.0072 16.1 1.0 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Death PF00531.22 PIK41998.1 - 1.5e-08 34.6 0.3 7.9e-08 32.4 0.1 2.1 2 0 0 2 2 2 1 Death domain ZU5 PF00791.20 PIK41998.1 - 0.00016 21.9 0.0 0.00032 21.0 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK41998.1 - 0.026 14.8 0.5 0.058 13.7 0.5 1.6 1 0 0 1 1 1 0 Death effector domain A_deaminase PF00962.22 PIK41998.1 - 0.13 11.5 0.0 0.82 8.9 0.0 2.0 2 0 0 2 2 2 0 Adenosine/AMP deaminase Ubiquitin_2 PF14560.6 PIK41999.1 - 0.048 14.1 0.4 0.22 12.0 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-like domain DED PF01335.21 PIK41999.1 - 0.095 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Death effector domain DUF4121 PF13497.6 PIK41999.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) ZU5 PF00791.20 PIK42000.1 - 6.1e-13 49.0 0.1 1.3e-12 47.9 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK42000.1 - 6.1e-12 45.5 0.7 1.1e-11 44.7 0.7 1.4 1 0 0 1 1 1 1 Death domain DUF2653 PF10850.8 PIK42000.1 - 0.036 14.3 0.0 0.073 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) PLN_propep PF16485.5 PIK42000.1 - 0.16 11.7 0.1 6.3 6.6 0.0 2.9 3 0 0 3 3 3 0 Protealysin propeptide Beta_propel PF09826.9 PIK42001.1 - 0.014 14.3 0.0 0.028 13.3 0.0 1.4 1 1 0 1 1 1 0 Beta propeller domain RT_RNaseH PF17917.1 PIK42002.1 - 8.8e-30 103.1 0.0 1.6e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42002.1 - 1.4e-26 93.4 0.0 4e-26 91.9 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK42002.1 - 1.1e-25 89.6 0.0 2.1e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK42003.1 - 2.5e-22 79.3 0.0 3.9e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK42003.1 - 2.7e-07 30.6 2.7 2.1e-06 27.7 2.0 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK42003.1 - 3e-05 23.7 0.0 6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF4906 PF16249.5 PIK42004.1 - 0.046 13.6 0.3 0.088 12.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4906) RVT_1 PF00078.27 PIK42005.1 - 3.7e-29 101.8 0.0 5.7e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK42006.1 - 2.8e-05 24.0 16.1 0.0035 17.3 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42006.1 - 7.8e-05 22.4 6.2 0.0032 17.3 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42006.1 - 0.00031 20.4 14.2 0.53 10.1 1.1 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK42006.1 - 2.1 8.7 12.3 0.85 9.9 7.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK42006.1 - 7.6 6.4 12.9 0.97 9.2 0.3 3.9 4 0 0 4 4 4 0 C2H2 zinc-finger V-set PF07686.17 PIK42007.1 - 1.2e-09 38.3 2.0 0.00039 20.5 0.2 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42007.1 - 2.7e-08 34.3 3.7 0.44 11.2 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK42007.1 - 0.00016 21.7 0.9 0.003 17.6 0.1 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK42007.1 - 0.00077 19.8 3.3 1.5 9.2 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK42007.1 - 0.00087 19.4 2.5 0.39 10.9 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin domain C1-set PF07654.15 PIK42007.1 - 0.0017 18.7 8.6 0.62 10.5 0.1 3.8 4 0 0 4 4 4 2 Immunoglobulin C1-set domain I-set PF07679.16 PIK42007.1 - 0.0075 16.3 1.4 9 6.4 0.0 3.5 4 0 0 4 4 4 2 Immunoglobulin I-set domain zf-CCHC PF00098.23 PIK42008.1 - 1.1e-05 25.3 16.1 0.0027 17.7 3.3 3.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42008.1 - 3.9e-05 23.4 6.2 0.0025 17.6 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42008.1 - 0.00013 21.6 14.2 0.4 10.4 1.1 3.6 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK42008.1 - 1.2 9.4 12.4 2.1 8.7 9.2 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK42008.1 - 3.1 7.6 12.9 0.75 9.6 0.3 4.0 4 0 0 4 4 4 0 C2H2 zinc-finger Transposase_21 PF02992.14 PIK42009.1 - 0.0044 16.3 0.0 0.015 14.6 0.0 1.9 2 0 0 2 2 2 1 Transposase family tnp2 zf-CCHC PF00098.23 PIK42010.1 - 8.6e-06 25.6 17.5 0.002 18.1 3.3 3.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42010.1 - 1.2e-05 25.0 0.1 1.2e-05 25.0 0.1 3.0 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42010.1 - 0.00043 20.0 14.3 0.28 11.0 1.0 3.4 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK42010.1 - 0.74 10.1 12.2 0.46 10.8 6.9 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RT_RNaseH PF17917.1 PIK42011.1 - 1.3e-35 121.9 0.0 2.6e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK42011.1 - 4.7e-29 100.4 0.0 9.9e-29 99.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42011.1 - 2e-16 60.2 0.0 3.4e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MATalpha_HMGbox PF04769.12 PIK42011.1 - 0.061 12.6 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SCAN PF02023.17 PIK42012.1 - 2.4e-12 46.5 0.1 5e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK42012.1 - 0.0012 19.1 0.8 0.39 11.0 0.1 2.5 1 1 1 2 2 2 2 Retrotransposon gag protein EMC3_TMCO1 PF01956.16 PIK42012.1 - 0.49 10.1 4.2 0.48 10.2 2.1 1.9 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like zf-CCHC PF00098.23 PIK42016.1 - 7.5e-06 25.8 16.2 0.0013 18.7 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK42016.1 - 0.0014 18.5 7.1 0.22 11.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK42016.1 - 0.021 14.8 12.4 0.47 10.5 1.1 3.8 1 1 2 3 3 3 0 Zinc knuckle DUF4371 PF14291.6 PIK42016.1 - 0.026 14.1 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) zf-CCHC_2 PF13696.6 PIK42016.1 - 0.045 13.6 0.2 0.045 13.6 0.2 3.8 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK42016.1 - 0.046 13.5 0.8 0.046 13.5 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK42016.1 - 3 7.7 15.7 10 6.0 0.4 4.1 3 1 1 4 4 4 0 Zinc knuckle DUF4371 PF14291.6 PIK42017.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) RVT_1 PF00078.27 PIK42018.1 - 4.3e-12 46.0 0.0 5.6e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK42021.1 - 1.6e-05 24.7 16.1 0.003 17.6 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42021.1 - 4.8e-05 23.1 6.2 0.0027 17.5 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42021.1 - 0.00011 21.8 14.2 0.44 10.3 1.1 3.9 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK42021.1 - 1.5 9.1 12.4 2.4 8.5 9.3 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK42021.1 - 4.2 7.2 12.9 0.81 9.5 0.3 3.9 4 0 0 4 4 4 0 C2H2 zinc-finger RVT_1 PF00078.27 PIK42022.1 - 3e-38 131.6 0.0 4e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tail_spike_N PF18668.1 PIK42023.1 - 0.0087 15.9 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Tail spike TSP1/Gp66 receptor binding N-terminal domain Ion_trans PF00520.31 PIK42024.1 - 1.8e-51 174.8 12.4 2.2e-51 174.4 12.4 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK42024.1 - 2e-11 43.7 7.5 2e-11 43.7 7.5 1.9 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 PIK42024.1 - 0.0065 15.2 3.8 0.011 14.4 3.8 1.2 1 0 0 1 1 1 1 Polycystin cation channel DUF4212 PF13937.6 PIK42024.1 - 0.68 10.4 5.1 1.3 9.4 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) BTB_2 PF02214.22 PIK42025.1 - 1.2e-29 102.4 0.0 1.8e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain 7tm_1 PF00001.21 PIK42026.1 - 1.6e-06 27.7 18.8 1.6e-06 27.7 18.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1072 PF06380.11 PIK42026.1 - 0.34 10.8 3.7 0.83 9.6 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1072) TMEM154 PF15102.6 PIK42026.1 - 3.7 7.5 5.0 1.2 9.1 1.3 2.0 2 0 0 2 2 2 0 TMEM154 protein family XK-related PF09815.9 PIK42027.1 - 8.2e-116 386.8 27.3 9.4e-116 386.6 27.3 1.0 1 0 0 1 1 1 1 XK-related protein Pkinase PF00069.25 PIK42028.1 - 1.4e-20 73.8 0.4 3.4e-16 59.4 0.3 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK42028.1 - 8.4e-18 64.6 0.0 1.7e-14 53.7 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase NleF_casp_inhib PF16809.5 PIK42028.1 - 8.2e-05 22.6 0.6 0.00091 19.2 0.1 2.3 2 0 0 2 2 2 1 NleF caspase inhibitor OSR1_C PF12202.8 PIK42028.1 - 0.0033 17.6 0.4 0.017 15.3 0.4 2.3 1 1 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Nif11 PF07862.11 PIK42028.1 - 0.13 12.5 0.4 1.9 8.9 0.3 2.7 2 0 0 2 2 2 0 Nif11 domain Tektin PF03148.14 PIK42029.1 - 1.9e-131 438.4 39.6 2.2e-131 438.2 39.6 1.0 1 0 0 1 1 1 1 Tektin family DUF4635 PF15466.6 PIK42029.1 - 0.0017 17.9 7.0 0.085 12.4 1.7 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4635) Fib_alpha PF08702.10 PIK42029.1 - 0.053 13.7 0.7 0.053 13.7 0.7 3.9 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family PITH PF06201.13 PIK42031.1 - 2.9e-21 76.3 0.0 3.4e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain PBECR1 PF18809.1 PIK42031.1 - 0.14 12.8 0.0 0.19 12.4 0.0 1.4 1 1 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 Ribonuc_red_sm PF00268.21 PIK42032.1 - 9.1e-120 399.3 3.3 1.2e-119 399.0 3.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain IFP_35_N PF07334.13 PIK42032.1 - 2 8.5 6.1 5.4 7.2 4.4 2.3 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus UDPGT PF00201.18 PIK42033.1 - 4.5e-102 342.4 0.0 6.1e-102 342.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK42033.1 - 3.1e-05 24.0 0.0 5.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 PIK42033.1 - 0.043 13.1 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 1 Glyco_trans_1_4 PF13692.6 PIK42033.1 - 0.055 13.9 0.0 0.13 12.7 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 Peptidase_A17 PF05380.13 PIK42034.1 - 6.5e-58 195.3 0.0 1.2e-57 194.5 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase RAP1 PF07218.11 PIK42034.1 - 0.011 14.1 0.1 0.017 13.5 0.1 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DNA_pol_viral_C PF00336.18 PIK42034.1 - 0.079 12.3 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RPN7 PF10602.9 PIK42034.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 gag-asp_proteas PF13975.6 PIK42036.1 - 0.0006 20.3 0.0 0.0019 18.7 0.0 1.9 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK42036.1 - 0.00087 19.9 0.0 0.002 18.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 PIK42036.1 - 0.0086 15.9 0.0 0.018 14.8 0.0 1.6 1 1 0 1 1 1 1 Putative peptidase (DUF1758) zf-CCHC_5 PF14787.6 PIK42036.1 - 0.046 13.4 0.9 0.046 13.4 0.9 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF1759 PF03564.15 PIK42037.1 - 5e-06 26.5 0.1 1.2e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) SHIPPO-rpt PF07004.12 PIK42038.1 - 2.5e-06 28.2 31.1 0.54 11.3 0.2 7.5 7 1 0 7 7 7 6 Sperm-tail PG-rich repeat AJAP1_PANP_C PF15298.6 PIK42040.1 - 0.27 11.4 7.3 0.56 10.4 7.3 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF4713 PF15831.5 PIK42040.1 - 5.7 7.5 16.4 10 6.7 16.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) GIY-YIG PF01541.24 PIK42041.1 - 5.8e-05 23.3 1.4 7.3e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 GIY-YIG catalytic domain OAD_gamma PF04277.13 PIK42041.1 - 1.4 9.5 12.1 1.7 9.3 0.1 3.4 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_L7Ae PF01248.26 PIK42043.1 - 5.2e-28 96.6 1.9 6.5e-28 96.3 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family MAM PF00629.23 PIK42044.1 - 0.0009 19.2 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Fibrinogen_C PF00147.18 PIK42045.1 - 6.1e-43 147.2 15.0 3.6e-42 144.7 15.0 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK42045.1 - 1.9e-09 37.3 13.5 1.9e-09 37.3 13.5 4.5 2 2 1 3 3 3 1 TILa domain TIL PF01826.17 PIK42045.1 - 0.00014 22.1 11.2 0.00014 22.1 11.2 4.5 3 2 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK42045.1 - 0.012 15.8 13.8 0.012 15.8 13.8 4.6 3 2 1 4 4 4 0 EGF domain 7tm_1 PF00001.21 PIK42047.1 - 2e-21 76.5 6.4 2.3e-21 76.3 6.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK42047.1 - 3.5e-05 23.2 3.9 4.1e-05 23.0 3.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw STE3 PF02076.15 PIK42047.1 - 0.00062 19.1 2.9 0.0016 17.7 3.0 1.6 1 1 0 1 1 1 1 Pheromone A receptor TssN PF17555.2 PIK42047.1 - 0.0087 15.5 1.0 0.011 15.1 1.0 1.1 1 0 0 1 1 1 1 Type VI secretion system, TssN AgrB PF04647.15 PIK42047.1 - 0.017 14.4 2.9 0.03 13.7 2.9 1.5 1 1 0 1 1 1 0 Accessory gene regulator B Piezo_RRas_bdg PF12166.8 PIK42047.1 - 0.018 14.3 0.3 0.02 14.2 0.3 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain 7TM_GPCR_Srsx PF10320.9 PIK42047.1 - 0.024 14.0 6.1 0.03 13.7 6.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4790 PF16037.5 PIK42047.1 - 0.041 14.4 0.1 0.2 12.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) Ribosomal_L17 PF01196.19 PIK42048.1 - 1.7e-18 67.3 0.0 2.6e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Kelch_1 PF01344.25 PIK42049.1 - 1.1e-65 216.9 22.0 5.4e-15 54.7 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK42049.1 - 7.8e-35 118.0 11.4 1.5e-09 37.8 0.0 6.3 3 2 3 6 6 6 6 Kelch motif Kelch_2 PF07646.15 PIK42049.1 - 8e-26 89.0 13.9 1e-07 31.7 0.0 6.5 5 1 1 6 6 6 5 Kelch motif BACK PF07707.15 PIK42049.1 - 2.9e-23 81.9 1.3 8e-23 80.5 1.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 PIK42049.1 - 9.2e-20 70.4 6.5 0.00013 21.9 0.0 5.0 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK42049.1 - 2e-18 66.2 14.5 2.9e-06 27.4 0.0 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK42049.1 - 9.1e-10 38.3 10.2 0.043 13.8 0.1 6.0 6 0 0 6 6 6 3 Kelch motif BTB PF00651.31 PIK42049.1 - 1.5e-06 28.4 0.3 7e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain PPP4R2 PF09184.11 PIK42049.1 - 0.5 9.9 16.9 0.89 9.1 16.9 1.4 1 0 0 1 1 1 0 PPP4R2 DDRGK PF09756.9 PIK42049.1 - 1.6 8.3 11.9 2.7 7.5 11.9 1.3 1 0 0 1 1 1 0 DDRGK domain DNA_pol_phi PF04931.13 PIK42049.1 - 1.6 6.7 36.6 2.9 5.9 36.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi CNDH2_C PF16858.5 PIK42049.1 - 2.7 7.8 12.5 4.4 7.1 12.5 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF789 PF05623.12 PIK42049.1 - 3.1 7.4 4.6 5.1 6.7 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF789) NOA36 PF06524.12 PIK42049.1 - 3.9 6.7 28.3 7.9 5.7 28.3 1.5 1 0 0 1 1 1 0 NOA36 protein DUF3295 PF11702.8 PIK42049.1 - 5.8 6.2 18.7 13 5.0 18.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) BUD22 PF09073.10 PIK42049.1 - 8.2 5.6 28.5 12 5.1 28.5 1.2 1 0 0 1 1 1 0 BUD22 Integrase_H2C2 PF17921.1 PIK42051.1 - 2.4e-20 72.4 0.8 3.9e-20 71.7 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK42051.1 - 2.7e-09 37.3 0.0 1.8e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK42051.1 - 1.4e-05 25.2 0.2 3.6e-05 23.9 0.2 1.7 2 0 0 2 2 2 1 H2C2 zinc finger RVT_1 PF00078.27 PIK42052.1 - 4.3e-28 98.4 0.0 5.7e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK42053.1 - 1.9e-10 40.4 0.4 4.4e-10 39.2 0.4 1.6 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK42053.1 - 0.022 15.0 0.0 1.5 9.2 0.0 2.5 2 1 0 2 2 2 0 Retrotransposon gag protein ELK PF03789.13 PIK42053.1 - 0.094 12.8 0.6 0.28 11.3 0.6 1.8 1 0 0 1 1 1 0 ELK domain Asp_protease_2 PF13650.6 PIK42054.1 - 0.022 15.4 0.0 0.093 13.4 0.0 2.0 2 0 0 2 2 2 0 Aspartyl protease RT_RNaseH_2 PF17919.1 PIK42055.1 - 1.7e-37 127.4 0.0 3.5e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42055.1 - 1.3e-35 121.8 0.0 3e-35 120.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42055.1 - 2.6e-26 92.5 0.0 4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK42056.1 - 3.6e-17 62.7 0.0 7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK42056.1 - 2.1e-08 34.1 0.6 5.1e-08 32.9 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK42056.1 - 0.002 17.8 0.1 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK42056.1 - 0.06 13.4 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 DUF4407 PF14362.6 PIK42057.1 - 0.036 13.4 6.1 0.05 12.9 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Borrelia_P83 PF05262.11 PIK42057.1 - 3 6.3 12.1 3.8 5.9 12.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CDC45 PF02724.14 PIK42057.1 - 3.5 5.8 10.0 4.6 5.4 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase_Tyr PF07714.17 PIK42058.1 - 2.6e-24 85.9 0.0 4.8e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42058.1 - 2.6e-12 46.7 0.0 4.3e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Marek_A PF02124.15 PIK42058.1 - 0.013 15.4 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A C2-set_2 PF08205.12 PIK42058.1 - 0.015 15.4 0.0 0.038 14.1 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain LRR_8 PF13855.6 PIK42059.1 - 3.2e-27 94.0 19.1 5.3e-10 38.9 5.3 4.5 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK42059.1 - 2.1e-12 47.0 23.3 0.00053 20.3 0.5 5.7 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK42059.1 - 9.2e-12 45.0 2.9 5.7e-06 26.3 0.0 2.7 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) RVT_1 PF00078.27 PIK42059.1 - 1.9e-07 30.9 0.1 3.4e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_9 PF14580.6 PIK42059.1 - 2.5e-05 23.8 6.9 0.051 13.1 0.2 3.5 1 1 3 4 4 4 3 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK42059.1 - 0.00018 21.2 18.3 0.0023 17.7 1.3 3.0 2 1 1 3 3 3 2 Putative ephrin-receptor like Pept_S41_N PF18294.1 PIK42059.1 - 0.13 12.3 0.9 2.9 7.9 0.6 2.9 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain LRR_1 PF00560.33 PIK42059.1 - 1.2 10.0 0.1 1.2 10.0 0.1 6.5 7 2 0 7 7 7 0 Leucine Rich Repeat NCD3G PF07562.14 PIK42059.1 - 1.3 9.1 15.4 0.57 10.2 0.7 3.2 1 1 3 4 4 4 0 Nine Cysteines Domain of family 3 GPCR DUF4231 PF14015.6 PIK42060.1 - 4.7 7.7 7.6 1.8 9.1 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) Syntaxin-6_N PF09177.11 PIK42061.1 - 0.019 15.5 3.9 0.052 14.1 1.1 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Atg14 PF10186.9 PIK42061.1 - 0.055 12.5 4.9 0.083 12.0 4.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Noelin-1 PF12308.8 PIK42061.1 - 0.21 11.6 2.2 0.33 10.9 1.5 1.7 2 0 0 2 2 2 0 Neurogenesis glycoprotein HAUS-augmin3 PF14932.6 PIK42061.1 - 0.54 9.8 11.2 0.88 9.1 11.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF5595 PF18077.1 PIK42061.1 - 0.55 10.4 4.8 1.3 9.1 4.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Ly49 PF08391.10 PIK42061.1 - 0.99 9.8 4.0 1.9 8.9 4.0 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region YabA PF06156.13 PIK42061.1 - 1.3 9.7 5.6 2.2 9.0 2.5 2.2 2 0 0 2 2 2 0 Initiation control protein YabA TMPIT PF07851.13 PIK42061.1 - 2.5 7.3 4.2 3.5 6.8 4.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Fez1 PF06818.15 PIK42061.1 - 3.3 8.1 16.7 2.4 8.6 13.3 2.3 2 1 0 2 2 2 0 Fez1 OmpH PF03938.14 PIK42061.1 - 9.2 6.6 16.4 0.45 10.8 10.3 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Aminotran_1_2 PF00155.21 PIK42062.1 - 4.6e-12 45.8 0.0 5.1e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Neur_chan_memb PF02932.16 PIK42063.1 - 3.8e-08 33.7 0.6 0.00033 20.8 0.0 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region TPR_2 PF07719.17 PIK42064.1 - 4e-33 110.8 18.5 4.4e-05 23.3 0.6 10.8 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42064.1 - 7.8e-32 107.8 15.5 0.00019 21.1 1.7 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42064.1 - 2.1e-29 99.2 15.0 0.0012 18.9 0.1 9.4 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 PIK42064.1 - 6.6e-23 80.1 7.7 1.7e-05 24.4 0.0 9.3 6 3 4 10 10 10 6 TPR repeat TPR_16 PF13432.6 PIK42064.1 - 6.5e-18 65.1 3.0 0.009 16.6 0.0 7.7 5 3 3 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 PIK42064.1 - 1.4e-17 63.7 15.5 0.00024 21.3 0.4 6.9 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 PIK42064.1 - 1.5e-16 60.6 9.8 0.00017 22.0 0.2 6.2 4 2 3 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK42064.1 - 1.4e-14 54.1 25.0 0.00013 22.1 0.6 5.8 3 1 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 PIK42064.1 - 2.5e-14 52.7 6.3 0.0097 16.7 0.0 7.9 4 3 5 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 PIK42064.1 - 3.6e-14 52.7 1.5 0.00028 21.0 0.0 5.7 3 3 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK42064.1 - 6e-14 51.3 7.5 4.9e-05 23.4 0.0 8.1 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK42064.1 - 7.1e-12 44.5 14.5 0.072 13.2 0.1 9.0 10 0 0 10 10 9 3 Tetratricopeptide repeat NARP1 PF12569.8 PIK42064.1 - 1.2e-08 34.4 5.3 4.1e-06 26.0 0.4 3.2 2 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 PIK42064.1 - 1.3e-07 31.8 18.1 4.9 8.0 0.1 9.3 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK42064.1 - 4.2e-07 29.5 8.0 6.4e-05 22.3 0.9 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 PIK42064.1 - 8.9e-06 26.0 0.4 0.0095 16.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK42064.1 - 2.1e-05 23.7 1.6 0.0071 15.4 0.1 3.3 1 1 2 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) PknG_TPR PF16918.5 PIK42064.1 - 4.1e-05 22.5 0.1 0.13 11.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase G tetratricopeptide repeat TPR_10 PF13374.6 PIK42064.1 - 0.0008 19.2 9.7 6 6.9 0.3 6.4 6 1 1 7 7 7 1 Tetratricopeptide repeat Coatomer_E PF04733.14 PIK42064.1 - 0.00099 18.6 6.0 0.19 11.1 0.6 2.9 2 1 1 3 3 3 2 Coatomer epsilon subunit TPR_MalT PF17874.1 PIK42064.1 - 0.002 17.6 4.8 0.0084 15.5 0.3 3.2 2 1 0 3 3 3 1 MalT-like TPR region Wzy_C_2 PF11846.8 PIK42064.1 - 0.0022 17.9 2.5 3 7.7 0.0 3.8 4 0 0 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.6 PIK42064.1 - 0.0062 16.0 8.1 0.017 14.6 0.1 3.0 3 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP DUF4810 PF16068.5 PIK42064.1 - 0.046 14.3 0.2 11 6.7 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4810) EF-hand_1 PF00036.32 PIK42065.1 - 1.2e-11 43.3 3.0 1.5e-06 27.3 0.1 3.8 4 0 0 4 4 4 2 EF hand Acyltransferase PF01553.21 PIK42065.1 - 1.3e-11 44.3 0.0 2.6e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase EF-hand_7 PF13499.6 PIK42065.1 - 2.9e-10 40.5 2.8 2.6e-09 37.4 0.1 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK42065.1 - 1.1e-09 38.0 3.9 0.00056 19.7 0.0 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK42065.1 - 2e-09 36.6 4.0 8.8e-05 22.1 0.0 4.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 PIK42065.1 - 0.00023 20.5 0.0 0.0007 19.0 0.0 1.9 1 0 0 1 1 1 1 EF hand DUF4734 PF15881.5 PIK42065.1 - 0.14 12.3 0.1 0.44 10.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) Acyl_transf_3 PF01757.22 PIK42066.1 - 3.4e-06 26.4 59.8 1.4e-05 24.4 54.6 2.8 2 1 0 2 2 2 1 Acyltransferase family LRR19-TM PF15176.6 PIK42066.1 - 0.18 11.8 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain adh_short_C2 PF13561.6 PIK42067.1 - 1.3e-62 211.4 0.1 1.8e-62 211.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK42067.1 - 3.8e-52 176.6 0.1 4.7e-52 176.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK42067.1 - 2.6e-07 30.7 0.0 3.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 PIK42067.1 - 0.0082 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DFP PF04127.15 PIK42067.1 - 0.083 12.7 0.1 0.26 11.1 0.1 1.8 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DSPc PF00782.20 PIK42068.1 - 2.1e-34 118.2 1.0 2.1e-34 118.2 1.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK42068.1 - 1.8e-05 24.4 0.6 1.8e-05 24.4 0.6 1.7 1 1 1 2 2 2 1 Protein-tyrosine phosphatase FbpA PF05833.11 PIK42068.1 - 0.0029 16.5 1.7 0.008 15.0 0.2 2.0 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) PTPlike_phytase PF14566.6 PIK42068.1 - 0.0088 16.2 0.2 0.0088 16.2 0.2 2.1 2 0 0 2 2 2 1 Inositol hexakisphosphate Peptidase_S46 PF10459.9 PIK42068.1 - 0.019 13.6 0.0 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 Peptidase S46 CDKN3 PF05706.12 PIK42068.1 - 0.036 13.8 0.4 0.079 12.6 0.3 1.6 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF3837 PF12939.7 PIK42068.1 - 0.077 13.4 2.6 0.2 12.1 2.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) Sulfotransfer_1 PF00685.27 PIK42069.1 - 1e-18 67.8 0.0 1.3e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK42069.1 - 1.7e-09 38.4 0.0 0.0029 18.0 0.0 3.0 2 1 1 3 3 3 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK42069.1 - 0.053 13.4 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK42070.1 - 1.4e-23 83.8 0.0 3.5e-23 82.4 0.0 1.6 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK42070.1 - 4.8e-09 36.9 0.0 0.0029 18.0 0.0 3.0 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK42070.1 - 0.036 14.0 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Sulfotransferase family TAF4 PF05236.14 PIK42071.1 - 5.1e-59 200.3 8.9 5.1e-59 200.3 8.9 2.3 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.14 PIK42071.1 - 2.8e-32 110.7 0.4 1.1e-31 108.8 0.4 2.0 1 0 0 1 1 1 1 NHR1 homology to TAF Glyoxalase_6 PF18029.1 PIK42071.1 - 0.099 13.4 0.0 0.22 12.3 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase-like domain Phospholamban PF04272.14 PIK42071.1 - 0.16 11.5 0.1 0.41 10.2 0.1 1.6 1 0 0 1 1 1 0 Phospholamban zf-CCHC PF00098.23 PIK42072.1 - 1.7e-05 24.7 1.1 2.9e-05 23.9 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle ABC_tran_Xtn PF12848.7 PIK42072.1 - 0.0064 16.5 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 ABC transporter RVT_1 PF00078.27 PIK42073.1 - 6e-05 22.7 0.0 9.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK42073.1 - 0.0036 17.6 0.0 0.012 15.9 0.0 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK42073.1 - 0.0047 17.5 0.0 0.012 16.2 0.0 1.8 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK42073.1 - 0.0055 17.3 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RT_RNaseH_2 PF17919.1 PIK42074.1 - 1.2e-09 38.1 0.0 1.8e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42074.1 - 0.0017 17.9 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK42075.1 - 4.2e-21 75.3 0.0 7.4e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK42075.1 - 3.3e-06 26.8 1.6 6.2e-06 25.9 0.5 2.0 1 1 1 2 2 2 1 Integrase core domain NUDIX_2 PF13869.6 PIK42076.1 - 3.7e-76 254.9 0.0 4.4e-76 254.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase PQ-loop PF04193.14 PIK42077.1 - 9.6e-24 82.9 9.7 1.9e-15 56.4 0.6 2.9 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 PIK42077.1 - 0.00015 22.7 8.1 0.3 11.9 5.8 2.4 2 0 0 2 2 2 2 ER lumen protein retaining receptor DUF2678 PF10856.8 PIK42077.1 - 1.1 9.2 7.3 0.39 10.7 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2678) SNARE_assoc PF09335.11 PIK42078.1 - 1.4e-08 35.3 0.5 2.4e-08 34.5 0.2 1.5 2 0 0 2 2 2 1 SNARE associated Golgi protein Spore_YhaL PF14147.6 PIK42078.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Sporulation protein YhaL Inhibitor_I9 PF05922.16 PIK42079.1 - 8.5e-08 32.8 0.2 6.3e-07 30.0 0.2 1.9 1 1 0 1 1 1 1 Peptidase inhibitor I9 RVT_1 PF00078.27 PIK42080.1 - 9.2e-21 74.4 0.0 1.6e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pox_P35 PF03213.14 PIK42080.1 - 0.12 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein DUF3106 PF11304.8 PIK42080.1 - 0.18 12.3 5.8 2.8 8.5 2.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3106) Vps35 PF03635.17 PIK42081.1 - 6e-291 967.3 13.5 7e-291 967.1 13.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 DUF1943 PF09172.11 PIK42081.1 - 0.0076 15.5 0.5 0.1 11.8 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) TIM21 PF08294.11 PIK42082.1 - 5.5e-44 149.6 0.2 7.2e-44 149.2 0.2 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 PIK42082.1 - 9.4e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Katanin_con80 PF13925.6 PIK42083.1 - 4.3e-51 173.1 0.6 5.1e-51 172.9 0.6 1.1 1 0 0 1 1 1 1 con80 domain of Katanin Sec5 PF15469.6 PIK42085.1 - 6e-43 146.9 2.1 1.5e-42 145.6 2.1 1.7 1 0 0 1 1 1 1 Exocyst complex component Sec5 TIG PF01833.24 PIK42085.1 - 2.4e-08 34.0 2.0 6.6e-08 32.5 2.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain RINT1_TIP1 PF04437.13 PIK42085.1 - 0.021 13.8 0.0 0.087 11.7 0.0 1.9 2 0 0 2 2 2 0 RINT-1 / TIP-1 family Ras PF00071.22 PIK42086.1 - 2.5e-58 196.3 0.1 3.2e-58 195.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK42086.1 - 1.1e-29 103.1 0.1 2.8e-29 101.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK42086.1 - 3.9e-11 42.7 0.1 5.2e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK42086.1 - 0.003 17.1 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK42086.1 - 0.0043 16.5 0.0 0.0059 16.0 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK42086.1 - 0.027 14.5 0.0 0.043 13.9 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase SNF2_N PF00176.23 PIK42087.1 - 5.9e-46 156.8 3.1 7.9e-29 100.5 0.7 2.5 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK42087.1 - 4.7e-19 68.8 0.9 1.7e-17 63.8 0.0 3.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Chromo PF00385.24 PIK42087.1 - 1.3e-06 28.1 0.3 4e-06 26.6 0.3 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain NACHT PF05729.12 PIK42089.1 - 1.7e-14 54.1 0.0 3.3e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ig_2 PF13895.6 PIK42089.1 - 0.00037 20.8 0.1 0.28 11.6 0.0 3.3 2 2 1 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK42089.1 - 0.0004 20.9 0.7 0.14 12.8 0.0 3.2 2 1 0 2 2 2 1 Immunoglobulin domain NB-ARC PF00931.22 PIK42089.1 - 0.0041 16.4 0.0 0.0075 15.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain V-set PF07686.17 PIK42089.1 - 0.0042 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK42089.1 - 0.016 14.8 0.0 0.047 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain TMEM154 PF15102.6 PIK42089.1 - 0.017 15.0 0.8 0.017 15.0 0.8 1.7 2 0 0 2 2 2 0 TMEM154 protein family ECSCR PF15820.5 PIK42089.1 - 0.059 13.2 0.4 0.12 12.2 0.4 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DAG1 PF05454.11 PIK42089.1 - 0.11 11.9 0.2 0.16 11.3 0.2 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DAP3 PF10236.9 PIK42089.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK42089.1 - 0.13 12.6 0.0 0.35 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain C2-set_2 PF08205.12 PIK42089.1 - 0.17 12.0 0.1 0.39 10.8 0.1 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK42089.1 - 0.18 12.0 0.3 0.69 10.1 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain Integrase_H2C2 PF17921.1 PIK42090.1 - 8.5e-20 70.6 1.4 1.3e-19 70.0 1.4 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK42090.1 - 0.0015 18.7 1.0 0.0035 17.5 1.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK42091.1 - 6.6e-09 35.7 0.0 1.2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK42091.1 - 1e-07 32.4 0.0 2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK42091.1 - 1.7e-06 28.6 0.0 3.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 PIK42091.1 - 0.022 14.5 0.0 0.056 13.2 0.0 1.7 1 1 0 1 1 1 0 Aspartyl protease fn3 PF00041.21 PIK42092.1 - 1.4e-44 150.3 1.1 4.1e-16 59.1 0.1 3.2 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK42092.1 - 2.5e-06 28.0 1.3 0.28 11.8 0.0 4.1 3 2 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK42092.1 - 2.6e-06 27.7 0.1 0.022 15.1 0.0 3.2 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 PIK42092.1 - 4.4e-05 23.7 0.0 2 8.8 0.0 3.3 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III Ig_3 PF13927.6 PIK42093.1 - 5.6e-29 100.6 0.0 2.6e-11 43.9 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK42093.1 - 3.3e-26 91.2 0.0 6.5e-10 38.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42093.1 - 2.6e-17 62.9 0.0 2.6e-08 34.1 0.1 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK42093.1 - 3.4e-16 59.2 0.1 5.9e-06 26.4 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK42093.1 - 2.3e-14 53.5 0.1 4.7e-05 23.5 0.0 4.0 3 1 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK42093.1 - 0.00026 21.3 0.0 0.0077 16.6 0.0 3.1 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK42093.1 - 0.00072 19.8 0.0 0.063 13.5 0.0 2.9 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 PIK42093.1 - 0.0061 16.5 0.1 0.034 14.1 0.1 2.2 2 1 0 2 2 2 1 CD47 immunoglobulin-like domain C1-set PF07654.15 PIK42093.1 - 0.0067 16.8 0.0 0.29 11.6 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK42093.1 - 0.026 14.1 0.0 2.7 7.6 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain Ntox22 PF15527.6 PIK42093.1 - 0.059 13.4 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial toxin 22 C2-set_2 PF08205.12 PIK42093.1 - 0.067 13.3 0.0 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain His_Phos_2 PF00328.22 PIK42094.1 - 0.00014 21.4 0.0 0.00026 20.5 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Phage_capsid PF05065.13 PIK42094.1 - 0.076 12.3 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Phage capsid family His_Phos_2 PF00328.22 PIK42095.1 - 8.7e-06 25.3 0.0 1.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) zf-H2C2_2 PF13465.6 PIK42096.1 - 8e-19 67.2 12.3 3.2e-10 40.0 0.5 3.5 4 0 0 4 4 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK42096.1 - 1.4e-12 47.3 8.9 0.00031 21.3 0.5 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK42096.1 - 7.2e-12 45.1 16.8 3e-05 24.2 0.4 3.4 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK42096.1 - 1.4e-07 31.6 0.3 0.19 12.1 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK42096.1 - 7.1e-07 29.4 1.3 0.0025 18.2 0.2 3.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK42096.1 - 0.00015 21.7 9.2 0.00095 19.1 0.2 2.7 3 0 0 3 3 2 2 C2H2-type zinc finger BolA PF01722.18 PIK42096.1 - 0.0014 18.8 0.3 1 9.7 0.0 2.6 1 1 2 3 3 3 2 BolA-like protein Rep_fac-A_C PF08646.10 PIK42096.1 - 0.015 15.0 1.2 0.14 11.9 0.2 2.0 1 1 1 2 2 2 0 Replication factor-A C terminal domain zf-C2H2_11 PF16622.5 PIK42096.1 - 0.022 14.5 6.8 2 8.3 0.4 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type BHD_1 PF10403.9 PIK42096.1 - 0.037 13.9 0.0 0.9 9.4 0.0 2.1 1 1 1 2 2 2 0 Rad4 beta-hairpin domain 1 zf-C2H2_2 PF12756.7 PIK42096.1 - 0.096 13.0 5.0 2.2 8.7 0.2 2.9 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) LIM PF00412.22 PIK42096.1 - 0.17 12.1 7.1 1.9 8.8 1.0 2.6 2 1 0 2 2 2 0 LIM domain zf-CHY PF05495.12 PIK42096.1 - 0.18 12.3 6.3 1.7 9.2 3.7 2.2 1 1 1 2 2 2 0 CHY zinc finger C1_4 PF07975.12 PIK42096.1 - 0.26 11.5 7.1 0.77 10.0 0.7 2.5 1 1 1 2 2 2 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 PIK42096.1 - 0.41 10.6 12.1 1.3 9.0 0.0 3.5 3 1 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK42096.1 - 0.49 10.9 8.1 1.4 9.4 0.3 2.9 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 PIK42096.1 - 1.1 9.5 9.1 1.4 9.1 2.4 3.1 1 1 2 3 3 3 0 Zinc ribbon domain Zf_RING PF16744.5 PIK42096.1 - 1.3 9.2 0.1 1.3 9.2 0.1 2.9 1 1 2 3 3 3 0 KIAA1045 RING finger Laminin_EGF PF00053.24 PIK42096.1 - 1.4 9.2 8.8 6.9 6.9 1.9 3.4 3 1 0 3 3 3 0 Laminin EGF domain zf-AN1 PF01428.16 PIK42096.1 - 2 8.7 13.2 3.9 7.7 0.1 3.5 4 0 0 4 4 3 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 PIK42096.1 - 2 9.1 8.4 12 6.6 0.3 3.0 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats NPL PF17800.1 PIK42097.1 - 3.2e-18 66.2 1.4 9.7e-18 64.7 0.0 2.3 2 0 0 2 2 2 1 Nucleoplasmin-like domain E2F_TDP PF02319.20 PIK42098.1 - 6.9e-39 131.8 0.3 1.1e-18 67.0 0.0 2.5 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 PIK42098.1 - 0.00039 20.2 0.0 0.00095 19.0 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RYDR_ITPR PF01365.21 PIK42098.1 - 0.055 12.9 0.2 0.1 12.0 0.2 1.4 1 0 0 1 1 1 0 RIH domain Spond_N PF06468.13 PIK42099.1 - 6.7e-47 160.1 0.1 1e-46 159.5 0.1 1.3 1 0 0 1 1 1 1 Spondin_N Reeler PF02014.16 PIK42099.1 - 1.1e-12 48.8 0.1 2e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 Reeler domain TSP_1 PF00090.19 PIK42099.1 - 2.1e-11 43.9 10.2 2.1e-11 43.9 10.2 2.7 2 0 0 2 2 2 1 Thrombospondin type 1 domain HLH PF00010.26 PIK42100.1 - 1.5e-09 37.7 1.0 1.9e-09 37.4 0.0 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Peptidase_A22B PF04258.13 PIK42101.1 - 9.8e-77 258.2 6.8 1.1e-76 258.1 6.8 1.0 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 PIK42101.1 - 5.4e-05 22.8 8.0 9.9e-05 21.9 8.0 1.4 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.17 PIK42101.1 - 0.0033 16.2 2.6 0.0033 16.2 2.6 1.6 1 1 0 2 2 2 1 Presenilin Metallothio PF00131.20 PIK42101.1 - 0.2 11.8 12.7 0.31 11.2 12.7 1.2 1 0 0 1 1 1 0 Metallothionein DUF5367 PF17329.2 PIK42101.1 - 4.4 7.5 9.5 0.058 13.5 1.5 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5367) Dcc1 PF09724.9 PIK42102.1 - 3.3e-39 135.1 1.6 2e-24 86.6 0.1 2.1 1 1 1 2 2 2 2 Sister chromatid cohesion protein Dcc1 Shisa PF13908.6 PIK42102.1 - 0.052 13.8 14.8 0.22 11.7 14.8 1.9 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator SRCR PF00530.18 PIK42104.1 - 7.4e-128 417.9 23.7 3.6e-29 101.2 0.9 5.1 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42104.1 - 1.7e-29 102.2 24.4 4.9e-06 27.0 0.0 6.2 6 1 0 6 6 6 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK42104.1 - 2.7e-12 47.2 0.1 0.4 11.2 0.0 5.5 5 0 0 5 5 5 4 Hepsin, SRCR domain Shisa PF13908.6 PIK42104.1 - 0.034 14.4 14.1 0.11 12.7 14.1 1.9 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5060 PF16586.5 PIK42104.1 - 0.069 13.5 0.2 1.1 9.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) YecR PF13992.6 PIK42104.1 - 0.095 13.0 9.3 5.7 7.3 0.2 5.0 5 0 0 5 5 5 0 YecR-like lipoprotein SRCR PF00530.18 PIK42105.1 - 2e-28 98.8 3.7 2.6e-24 85.6 0.1 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42105.1 - 9e-06 26.1 2.1 4.1e-05 24.0 2.1 2.2 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Shisa PF13908.6 PIK42105.1 - 0.00079 19.7 11.2 0.00079 19.7 11.2 2.7 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator SRCR PF00530.18 PIK42106.1 - 2.6e-15 56.7 0.0 4e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Shisa PF13908.6 PIK42106.1 - 8.7e-07 29.4 2.6 8.7e-07 29.4 2.6 2.1 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator SRCR_2 PF15494.6 PIK42106.1 - 0.012 16.1 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain Orthoreo_P10 PF07204.11 PIK42106.1 - 0.036 14.0 0.4 0.062 13.3 0.4 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 DUF3481 PF11980.8 PIK42106.1 - 1.5 8.6 4.5 2.7 7.8 4.5 1.3 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Prominin PF05478.11 PIK42106.1 - 2.1 6.2 5.9 2.8 5.8 5.9 1.1 1 0 0 1 1 1 0 Prominin Shisa PF13908.6 PIK42107.1 - 8e-06 26.2 3.7 8e-06 26.2 3.7 2.1 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator Pilin_N PF07790.11 PIK42107.1 - 0.011 16.7 1.0 0.02 15.8 1.0 1.4 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF3481 PF11980.8 PIK42107.1 - 0.84 9.4 3.4 1.3 8.8 3.4 1.2 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein zf-C3HC4 PF00097.25 PIK42108.1 - 1.4e-07 31.3 8.8 1.4e-07 31.3 8.8 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK42108.1 - 1.8e-06 27.9 7.4 7.9e-06 25.8 7.4 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK42108.1 - 7e-06 26.1 9.0 7e-06 26.1 9.0 3.3 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK42108.1 - 8.4e-06 25.5 9.6 8.4e-06 25.5 9.6 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK42108.1 - 0.00013 22.2 8.5 0.00013 22.2 8.5 3.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK42108.1 - 0.00018 21.4 8.9 0.00018 21.4 8.9 4.1 4 0 0 4 4 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK42108.1 - 0.00029 20.6 13.8 0.00029 20.6 13.8 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK42108.1 - 0.0041 17.2 7.3 0.0041 17.2 7.3 3.9 4 1 0 4 4 3 2 B-box zinc finger DUF3584 PF12128.8 PIK42108.1 - 2 5.8 26.1 2.7 5.4 26.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Mitofilin PF09731.9 PIK42108.1 - 2.1 7.1 28.0 3.1 6.5 28.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Exonuc_VII_L PF02601.15 PIK42108.1 - 6.6 6.2 14.0 13 5.2 14.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Neur_chan_LBD PF02931.23 PIK42109.1 - 5.8e-64 215.5 0.3 7.7e-64 215.1 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK42109.1 - 5.3e-36 124.9 0.0 6.8e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2417 PF10329.9 PIK42109.1 - 0.42 10.0 5.8 2.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF4149 PF13664.6 PIK42109.1 - 4.9 7.5 8.0 4.5 7.7 1.9 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) KxDL PF10241.9 PIK42110.1 - 0.031 14.6 1.4 0.031 14.6 1.4 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein Nmad5 PF18757.1 PIK42110.1 - 0.15 12.2 4.6 0.12 12.6 3.1 1.6 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 AFT PF08731.11 PIK42110.1 - 0.26 11.7 1.5 0.52 10.7 1.5 1.8 1 1 0 1 1 1 0 Transcription factor AFT DUF2120 PF09893.9 PIK42110.1 - 0.33 11.0 3.7 0.2 11.7 0.7 2.1 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Fzo_mitofusin PF04799.13 PIK42110.1 - 0.8 9.2 4.9 1.2 8.6 2.4 2.2 1 1 1 2 2 2 0 fzo-like conserved region APG6_N PF17675.1 PIK42110.1 - 1.5 9.4 14.7 1.3 9.5 11.0 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region LRRFIP PF09738.9 PIK42110.1 - 2 7.8 16.7 2.6 7.5 12.7 2.6 1 1 1 2 2 2 0 LRRFIP family DUF4201 PF13870.6 PIK42110.1 - 2.5 7.8 16.7 0.2 11.4 4.4 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4201) LPP PF04728.13 PIK42110.1 - 2.6 8.5 5.6 11 6.5 0.1 3.5 3 1 1 4 4 4 0 Lipoprotein leucine-zipper DUF1664 PF07889.12 PIK42110.1 - 2.7 8.1 6.1 1 9.4 2.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 PIK42110.1 - 3.3 6.9 9.4 0.17 11.1 2.8 1.9 1 1 2 3 3 3 0 TMPIT-like protein Fib_alpha PF08702.10 PIK42110.1 - 3.7 7.7 11.0 1.1 9.5 4.0 2.7 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family YabA PF06156.13 PIK42110.1 - 4.9 7.9 11.6 2.5 8.8 3.3 3.6 2 1 0 4 4 4 0 Initiation control protein YabA CLZ PF16526.5 PIK42110.1 - 8.3 6.8 10.4 1.5 9.2 0.3 3.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PRKG1_interact PF15898.5 PIK42110.1 - 8.8 7.3 16.1 14 6.7 2.9 4.0 2 1 1 4 4 4 0 cGMP-dependent protein kinase interacting domain SOGA PF11365.8 PIK42110.1 - 9.1 7.5 11.0 2 9.6 2.5 2.6 2 1 0 2 2 2 0 Protein SOGA Seryl_tRNA_N PF02403.22 PIK42110.1 - 9.7 6.5 17.1 1.9 8.8 2.0 3.3 3 1 1 4 4 3 0 Seryl-tRNA synthetase N-terminal domain GTP_EFTU PF00009.27 PIK42111.1 - 3.6e-63 212.6 0.1 6e-63 211.9 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 PIK42111.1 - 2.6e-28 97.9 0.0 5.6e-28 96.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 PIK42111.1 - 4.2e-24 84.4 0.0 1.2e-23 82.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 PIK42111.1 - 7.6e-09 35.5 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 PIK42111.1 - 5.7e-08 32.6 0.0 1.6e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 PIK42111.1 - 3e-05 24.3 0.0 7.1e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 PIK42111.1 - 0.0016 18.5 0.0 0.0038 17.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 PIK42111.1 - 0.018 14.4 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Ribosomal_S27e PF01667.17 PIK42111.1 - 0.039 13.7 0.6 0.17 11.6 0.4 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 Glyco_hydro_20 PF00728.22 PIK42112.1 - 2.1e-39 135.9 0.1 2.6e-39 135.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20 PF00728.22 PIK42113.1 - 1.5e-38 133.1 0.1 2.2e-38 132.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 PIK42113.1 - 4.9e-18 66.1 0.0 6.8e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 PIK42113.1 - 0.0046 17.7 0.0 0.0067 17.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Ribosomal_S11 PF00411.19 PIK42114.1 - 5.9e-19 68.5 0.7 1e-18 67.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_L18p PF00861.22 PIK42114.1 - 0.12 12.7 0.5 0.2 12.0 0.5 1.3 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Hist_rich_Ca-bd PF10529.9 PIK42114.1 - 0.16 12.2 5.8 0.39 11.0 5.8 1.7 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region LTD PF00932.19 PIK42115.1 - 1.4e-13 51.2 0.3 2.6e-13 50.3 0.3 1.4 1 0 0 1 1 1 1 Lamin Tail Domain Filament PF00038.21 PIK42115.1 - 1.3e-09 38.1 12.8 2.1e-09 37.4 12.8 1.3 1 0 0 1 1 1 1 Intermediate filament protein Fez1 PF06818.15 PIK42115.1 - 0.0059 17.1 4.4 0.0092 16.5 4.4 1.4 1 0 0 1 1 1 1 Fez1 G10 PF01125.17 PIK42115.1 - 0.0089 15.8 0.4 0.016 15.0 0.4 1.4 1 0 0 1 1 1 1 G10 protein Tho2 PF11262.8 PIK42115.1 - 0.013 14.7 8.4 0.025 13.8 8.4 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 ENT PF03735.14 PIK42115.1 - 0.042 13.9 1.7 0.1 12.7 1.7 1.7 1 0 0 1 1 1 0 ENT domain CALCOCO1 PF07888.11 PIK42115.1 - 0.044 12.7 9.7 0.072 11.9 9.7 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin_1 PF12718.7 PIK42115.1 - 0.076 13.2 9.4 0.24 11.6 9.2 1.8 1 1 0 1 1 1 0 Tropomyosin like DUF725 PF05267.12 PIK42115.1 - 0.18 11.8 1.1 0.27 11.2 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF725) DUF4200 PF13863.6 PIK42115.1 - 0.33 11.4 11.0 33 4.9 11.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) TMPIT PF07851.13 PIK42115.1 - 0.35 10.1 6.2 0.47 9.6 6.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 PIK42115.1 - 0.39 10.5 7.9 3.4 7.5 6.0 2.5 1 1 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 PIK42115.1 - 0.43 10.7 10.6 3.2 7.8 12.3 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Sec34 PF04136.15 PIK42115.1 - 0.59 10.0 6.5 3.5 7.5 0.3 2.2 1 1 1 2 2 2 0 Sec34-like family TolA_bind_tri PF16331.5 PIK42115.1 - 0.6 10.2 6.8 3.7 7.7 0.5 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF3450 PF11932.8 PIK42115.1 - 0.86 8.9 7.8 1.2 8.4 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Csm1_N PF18504.1 PIK42115.1 - 0.95 9.8 8.8 4 7.9 0.7 2.7 2 1 1 3 3 2 0 Csm1 N-terminal domain OmpH PF03938.14 PIK42115.1 - 1.1 9.6 7.5 2.3 8.6 7.5 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 PIK42115.1 - 1.5 9.4 13.5 3.8 8.0 13.5 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Spc24 PF08286.11 PIK42115.1 - 1.8 8.9 8.8 24 5.2 8.8 2.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Spc7 PF08317.11 PIK42115.1 - 1.8 7.4 11.5 1.5 7.6 9.7 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein CENP-H PF05837.12 PIK42115.1 - 6.9 7.1 11.3 0.55 10.7 6.1 1.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Filament PF00038.21 PIK42116.1 - 6.6e-09 35.8 13.1 5.5e-08 32.8 12.7 1.9 1 1 0 1 1 1 1 Intermediate filament protein Cast PF10174.9 PIK42116.1 - 0.00073 17.9 7.7 0.00091 17.6 7.7 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Tropomyosin PF00261.20 PIK42116.1 - 0.006 16.0 14.2 0.0093 15.4 14.2 1.3 1 1 0 1 1 1 1 Tropomyosin FPP PF05911.11 PIK42116.1 - 0.0062 14.8 9.1 0.0076 14.5 9.1 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Cortex-I_coil PF09304.10 PIK42116.1 - 0.011 16.0 12.4 0.022 15.0 12.4 1.5 1 1 0 1 1 1 0 Cortexillin I, coiled coil SlyX PF04102.12 PIK42116.1 - 0.011 16.4 5.3 1.5 9.5 2.1 2.3 2 0 0 2 2 2 0 SlyX ATG16 PF08614.11 PIK42116.1 - 0.017 15.4 14.6 0.048 13.9 13.5 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 PIK42116.1 - 0.022 14.3 7.4 0.028 13.9 7.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 APG6_N PF17675.1 PIK42116.1 - 0.023 15.2 12.0 0.029 14.9 12.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Mut7-C PF01927.16 PIK42116.1 - 0.028 14.5 3.6 0.086 12.9 3.6 1.8 1 1 0 1 1 1 0 Mut7-C RNAse domain HIP1_clath_bdg PF16515.5 PIK42116.1 - 0.036 14.7 11.6 3.3 8.4 9.1 2.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cnn_1N PF07989.11 PIK42116.1 - 0.038 14.1 13.8 0.042 14.0 6.1 2.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 BST2 PF16716.5 PIK42116.1 - 0.056 14.0 2.2 0.056 14.0 2.2 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 HAUS5 PF14817.6 PIK42116.1 - 0.065 12.0 6.5 0.071 11.9 6.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 Tropomyosin_1 PF12718.7 PIK42116.1 - 0.066 13.4 13.9 0.094 12.9 13.9 1.2 1 0 0 1 1 1 0 Tropomyosin like Baculo_F PF12259.8 PIK42116.1 - 0.069 11.7 2.1 0.072 11.6 2.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein SNCAIP_SNCA_bd PF16700.5 PIK42116.1 - 0.078 12.7 1.5 0.18 11.6 0.7 2.1 2 0 0 2 2 1 0 Synphilin-1 alpha-Synuclein-binding domain CENP-F_leu_zip PF10473.9 PIK42116.1 - 0.081 13.0 15.1 1 9.4 15.3 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HOOK PF05622.12 PIK42116.1 - 0.081 11.1 11.5 0.094 10.8 11.5 1.0 1 0 0 1 1 1 0 HOOK protein Spc7 PF08317.11 PIK42116.1 - 0.12 11.2 10.8 0.16 10.8 10.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Phlebovirus_NSM PF07246.11 PIK42116.1 - 0.13 11.6 5.8 0.15 11.5 5.8 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M HrpB7 PF09486.10 PIK42116.1 - 0.14 12.5 5.8 0.3 11.5 4.0 2.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) MPS2 PF17060.5 PIK42116.1 - 0.14 11.4 11.7 1.2 8.3 1.7 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 PEARLI-4 PF05278.12 PIK42116.1 - 0.15 11.6 9.0 0.19 11.3 9.0 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF1664 PF07889.12 PIK42116.1 - 0.16 12.0 4.5 1.4 8.9 3.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 PIK42116.1 - 0.23 12.1 9.5 1.5 9.5 9.5 2.0 1 1 0 1 1 1 0 Initiation control protein YabA Uso1_p115_C PF04871.13 PIK42116.1 - 0.26 11.7 13.6 0.37 11.2 13.6 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region BRE1 PF08647.11 PIK42116.1 - 0.27 11.3 12.9 0.21 11.7 8.1 2.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Nup54 PF13874.6 PIK42116.1 - 0.29 11.2 6.7 1.7 8.8 6.7 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 FAM76 PF16046.5 PIK42116.1 - 0.34 10.2 10.3 0.56 9.5 10.3 1.5 1 1 0 1 1 1 0 FAM76 protein HSP70 PF00012.20 PIK42116.1 - 0.38 8.9 5.1 0.4 8.8 5.1 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF1844 PF08899.11 PIK42116.1 - 0.5 10.7 3.5 0.37 11.1 1.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1844) DUF4349 PF14257.6 PIK42116.1 - 0.55 9.7 4.6 2.4 7.6 3.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) Lebercilin PF15619.6 PIK42116.1 - 0.64 9.7 16.8 12 5.5 14.1 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Macoilin PF09726.9 PIK42116.1 - 0.74 8.3 10.1 0.88 8.1 10.1 1.0 1 0 0 1 1 1 0 Macoilin family FlxA PF14282.6 PIK42116.1 - 0.88 9.6 6.8 0.53 10.3 2.5 1.9 1 1 1 2 2 2 0 FlxA-like protein Spc24 PF08286.11 PIK42116.1 - 0.97 9.7 12.4 8.3 6.7 12.4 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 NuA4 PF09340.10 PIK42116.1 - 1.1 9.2 8.5 19 5.2 0.6 3.0 1 1 2 3 3 3 0 Histone acetyltransferase subunit NuA4 FlaC_arch PF05377.11 PIK42116.1 - 1.3 9.5 8.8 9.3 6.7 0.0 3.2 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Fmp27_WPPW PF10359.9 PIK42116.1 - 1.3 7.7 7.9 2 7.2 7.9 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF641 PF04859.12 PIK42116.1 - 1.4 9.2 8.4 37 4.7 6.9 2.4 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Cep57_CLD_2 PF14197.6 PIK42116.1 - 1.6 8.9 15.7 1 9.5 0.3 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 OmpH PF03938.14 PIK42116.1 - 1.7 8.9 11.4 2.9 8.2 11.4 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CCDC-167 PF15188.6 PIK42116.1 - 2 8.8 13.1 0.98 9.8 5.9 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Swi5 PF07061.11 PIK42116.1 - 3.7 7.7 9.6 43 4.3 7.5 2.8 1 1 1 2 2 2 0 Swi5 DUF4407 PF14362.6 PIK42116.1 - 5.6 6.2 7.1 8.5 5.6 7.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4140 PF13600.6 PIK42116.1 - 8.6 6.9 10.3 4.2e+02 1.5 10.3 2.8 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TMPIT PF07851.13 PIK42116.1 - 8.6 5.5 6.9 34 3.5 6.8 1.8 1 1 0 1 1 1 0 TMPIT-like protein FemAB PF02388.16 PIK42116.1 - 9.1 5.0 8.1 2.6 6.8 3.9 1.7 1 1 1 2 2 2 0 FemAB family Med9 PF07544.13 PIK42116.1 - 9.7 6.4 14.0 5.1 7.3 6.3 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Filament PF00038.21 PIK42117.1 - 5.2e-26 92.0 6.9 6.1e-26 91.7 6.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Fungal_TACC PF12709.7 PIK42117.1 - 0.015 15.7 2.2 0.66 10.5 1.0 3.0 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF5384 PF17358.2 PIK42117.1 - 0.017 15.1 2.0 0.017 15.1 2.0 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5384) HD_2 PF12917.7 PIK42117.1 - 0.033 14.0 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme YabA PF06156.13 PIK42117.1 - 0.035 14.7 3.8 0.59 10.8 2.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA PMC2NT PF08066.12 PIK42117.1 - 0.12 13.0 1.5 0.18 12.5 1.5 1.3 1 0 0 1 1 1 0 PMC2NT (NUC016) domain DHR10 PF18595.1 PIK42117.1 - 0.8 9.8 14.2 0.08 13.0 2.8 2.4 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain BRCT_3 PF18428.1 PIK42118.1 - 3.5e-28 97.6 0.2 3.9e-28 97.5 0.2 1.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 PIK42118.1 - 0.0033 17.8 0.0 0.0039 17.6 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK42118.1 - 0.019 15.3 0.1 0.022 15.1 0.1 1.2 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 PIK42118.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.6 1 1 0 1 1 1 0 DNA ligase 3 BRCT domain TMEM251 PF15190.6 PIK42119.1 - 0.36 10.8 1.2 0.81 9.6 1.2 1.5 1 0 0 1 1 1 0 Transmembrane protein 251 TRP PF06011.12 PIK42119.1 - 2 7.0 5.0 0.6 8.8 1.3 1.9 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel CENP-H PF05837.12 PIK42120.1 - 1.2e-18 67.5 8.3 2.2e-16 60.3 0.6 3.3 3 1 0 3 3 3 2 Centromere protein H (CENP-H) Taxilin PF09728.9 PIK42120.1 - 0.0033 16.7 7.1 0.0033 16.7 7.1 1.6 2 0 0 2 2 2 1 Myosin-like coiled-coil protein Mto2_bdg PF12808.7 PIK42120.1 - 0.012 15.9 1.9 0.35 11.2 0.1 2.7 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1184 PF06683.11 PIK42120.1 - 0.026 14.1 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) TetR_C_37 PF18665.1 PIK42120.1 - 0.12 12.9 2.8 0.18 12.4 0.2 2.3 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain APG6_N PF17675.1 PIK42120.1 - 2 9.0 17.1 0.39 11.2 1.4 3.1 3 0 0 3 3 3 0 Apg6 coiled-coil region RNA_polI_A14 PF08203.11 PIK42120.1 - 2 9.2 5.5 0.28 12.0 0.7 2.1 2 1 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Ig_3 PF13927.6 PIK42121.1 - 0.0018 18.8 4.6 0.42 11.3 0.5 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK42122.1 - 4.1e-45 154.1 1.2 5.3e-45 153.7 1.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42122.1 - 2e-10 40.5 0.2 3.3e-10 39.8 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain EzrA PF06160.12 PIK42122.1 - 0.016 13.4 1.3 0.018 13.3 0.2 1.5 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Ykof PF07615.11 PIK42122.1 - 0.16 12.4 0.3 0.89 10.1 0.1 2.2 2 0 0 2 2 2 0 YKOF-related Family PAF-AH_p_II PF03403.13 PIK42123.1 - 3.9e-103 344.9 0.0 4.5e-103 344.7 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 PIK42123.1 - 7.4e-10 38.2 0.0 1.2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 PIK42123.1 - 1.1e-06 27.9 0.0 0.0023 17.0 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase DLH PF01738.18 PIK42123.1 - 1.7e-06 27.8 0.0 3.6e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 PIK42123.1 - 0.00047 19.5 0.0 0.19 10.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 PIK42123.1 - 0.0005 19.6 0.0 0.001 18.6 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 PIK42123.1 - 0.0045 15.7 0.0 0.074 11.7 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 PIK42123.1 - 0.024 15.2 0.0 0.033 14.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 PIK42123.1 - 0.083 12.5 0.0 0.46 10.1 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold C2-set_2 PF08205.12 PIK42125.1 - 0.0019 18.2 0.1 0.0036 17.4 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF4458 PF14660.6 PIK42125.1 - 0.002 18.3 0.3 0.23 11.7 0.1 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4458) Ig_3 PF13927.6 PIK42126.1 - 4e-06 27.3 1.0 0.0035 17.9 0.2 3.0 2 1 1 3 3 3 2 Immunoglobulin domain Herpes_gp2 PF05955.11 PIK42126.1 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Equine herpesvirus glycoprotein gp2 C1-set PF07654.15 PIK42126.1 - 0.0051 17.2 3.1 0.012 16.0 0.3 2.8 2 2 1 3 3 3 1 Immunoglobulin C1-set domain Marek_A PF02124.15 PIK42126.1 - 0.011 15.6 0.1 0.019 14.8 0.0 1.6 1 1 0 1 1 1 0 Marek's disease glycoprotein A ig PF00047.25 PIK42126.1 - 0.053 13.7 0.5 0.14 12.4 0.3 1.7 2 0 0 2 2 2 0 Immunoglobulin domain NACHT PF05729.12 PIK42127.1 - 3e-12 46.8 0.0 6.8e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain TMEM154 PF15102.6 PIK42127.1 - 0.0002 21.3 0.4 0.00063 19.7 0.4 1.9 1 0 0 1 1 1 1 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK42127.1 - 0.0062 16.1 1.6 0.045 13.3 0.1 2.6 2 0 0 2 2 2 1 Baculovirus 11 kDa family Shisa PF13908.6 PIK42127.1 - 0.0064 16.8 0.1 0.0064 16.8 0.1 2.1 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator C2-set_2 PF08205.12 PIK42127.1 - 0.012 15.7 0.7 0.036 14.1 0.7 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain TMIE PF16038.5 PIK42127.1 - 0.019 14.8 0.1 0.058 13.2 0.1 1.8 1 0 0 1 1 1 0 TMIE protein EphA2_TM PF14575.6 PIK42127.1 - 0.029 15.2 0.1 0.1 13.5 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Claudin_2 PF13903.6 PIK42127.1 - 0.17 11.6 0.7 0.33 10.7 0.3 1.6 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction ig PF00047.25 PIK42128.1 - 0.0015 18.7 1.0 1.3 9.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK42128.1 - 0.0033 17.8 4.6 0.03 14.7 0.2 2.9 3 1 0 3 3 3 1 Immunoglobulin C1-set domain Marek_A PF02124.15 PIK42128.1 - 0.1 12.4 0.0 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 Marek's disease glycoprotein A APP_E2 PF12925.7 PIK42129.1 - 1.6e-32 112.7 12.3 3.3e-32 111.7 12.3 1.5 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_amyloid PF10515.9 PIK42129.1 - 2.1e-22 79.4 0.5 9.3e-22 77.3 0.5 2.2 1 0 0 1 1 1 1 Beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.7 PIK42129.1 - 4e-20 72.3 3.7 4e-20 72.3 3.7 2.5 3 0 0 3 3 3 1 Copper-binding of amyloid precursor, CuBD APP_N PF02177.16 PIK42129.1 - 4.9e-16 58.9 1.6 1.1e-15 57.9 0.1 2.3 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Fib_alpha PF08702.10 PIK42129.1 - 1.9 8.7 13.4 0.3 11.3 0.4 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 PIK42129.1 - 4.5 6.8 14.1 8.4 5.9 14.0 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit LSM14 PF12701.7 PIK42131.1 - 0.14 12.2 0.4 0.89 9.7 0.0 2.4 2 1 0 2 2 2 0 Scd6-like Sm domain ACP_syn_III_C PF08541.10 PIK42131.1 - 0.15 12.3 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Spaetzle PF16077.5 PIK42131.1 - 0.23 12.0 1.1 0.64 10.6 0.3 2.0 1 1 1 2 2 2 0 Spaetzle Neur_chan_LBD PF02931.23 PIK42133.1 - 1.9e-30 106.0 0.0 2.2e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK42133.1 - 1e-23 84.7 10.8 1.4e-23 84.2 10.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK42134.1 - 7.9e-61 205.2 0.0 1.1e-60 204.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK42134.1 - 1.7e-52 178.8 0.4 2.4e-52 178.4 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2417 PF10329.9 PIK42134.1 - 0.49 9.8 7.2 0.48 9.8 2.6 2.3 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF2304 PF10066.9 PIK42134.1 - 7.9 6.8 13.1 3.4 7.9 5.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Neur_chan_LBD PF02931.23 PIK42135.1 - 1.1e-61 208.1 0.1 1.7e-61 207.5 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK42135.1 - 1.2e-32 113.9 0.0 2e-32 113.2 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3232 PF11554.8 PIK42135.1 - 0.15 12.4 0.4 2 8.8 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3232) PTH2 PF01981.16 PIK42136.1 - 4.5e-33 114.0 0.0 6.1e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF2000 PF09391.10 PIK42136.1 - 0.046 13.6 0.3 9.7 6.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2000) DUF3862 PF12978.7 PIK42136.1 - 0.14 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) CHGN PF05679.16 PIK42138.1 - 6.5e-155 516.9 0.1 7.4e-155 516.7 0.1 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 PIK42138.1 - 2.8e-10 39.7 0.0 6.8e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK42138.1 - 6.6e-06 25.8 0.2 0.047 13.2 0.0 3.3 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Fringe PF02434.16 PIK42139.1 - 2.2e-18 66.6 0.0 3.3e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Fringe-like CHGN PF05679.16 PIK42139.1 - 6.5e-10 38.5 0.4 8.3e-10 38.1 0.4 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Galactosyl_T PF01762.21 PIK42139.1 - 0.0041 17.0 0.1 0.03 14.2 0.1 2.0 1 1 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 PIK42139.1 - 0.17 11.3 0.0 0.74 9.3 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferase family 21 RNA_pol_Rpc82 PF05645.13 PIK42140.1 - 6.5e-24 85.1 0.9 2.7e-23 83.0 0.2 2.4 2 1 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 PIK42140.1 - 3e-19 68.9 1.8 1.6e-16 60.1 0.0 3.5 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 PIK42140.1 - 5.1e-08 32.7 1.1 0.0042 16.9 0.1 3.4 4 0 0 4 4 4 2 TFIIE alpha subunit TrmB PF01978.19 PIK42140.1 - 7.3e-06 25.8 0.1 0.044 13.7 0.0 3.2 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB Dpoe2NT PF12213.8 PIK42140.1 - 0.089 13.1 0.0 0.4 11.0 0.0 2.1 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal MutS_I PF01624.20 PIK42141.1 - 0.1 12.9 0.2 2.4 8.4 0.0 2.0 1 1 1 2 2 2 0 MutS domain I Acyl_transf_2 PF02273.15 PIK42141.1 - 0.1 11.8 0.0 0.12 11.6 0.0 1.0 1 0 0 1 1 1 0 Acyl transferase FMN_dh PF01070.18 PIK42142.1 - 1.5e-52 178.7 1.2 1.9e-52 178.5 1.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK42142.1 - 3.8e-09 36.0 2.1 5e-08 32.3 0.7 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK42142.1 - 3e-06 26.6 0.1 3.7e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK42142.1 - 0.0018 17.8 0.5 0.002 17.6 0.5 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK42142.1 - 0.0022 17.5 0.1 0.0034 16.9 0.1 1.4 1 1 0 1 1 1 1 Histidine biosynthesis protein DHO_dh PF01180.21 PIK42142.1 - 0.033 13.4 0.2 0.039 13.2 0.2 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase TPR_MLP1_2 PF07926.12 PIK42143.1 - 0.0056 16.7 4.5 0.0056 16.7 4.5 2.0 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein GIT_CC PF16559.5 PIK42143.1 - 0.27 11.1 4.2 1.1 9.1 4.1 2.1 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3475 PF11961.8 PIK42143.1 - 0.28 11.3 3.2 17 5.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) DUF1664 PF07889.12 PIK42143.1 - 0.96 9.5 4.3 2.5 8.2 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 PIK42143.1 - 5.8 6.4 9.4 7.6 6.0 8.9 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit RVT_1 PF00078.27 PIK42144.1 - 3.3e-21 75.8 0.2 5.3e-21 75.1 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1080 PF06439.11 PIK42146.1 - 0.015 15.4 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) MbeB_N PF04837.12 PIK42147.1 - 0.0088 16.3 1.2 0.021 15.1 1.2 1.6 1 0 0 1 1 1 1 MbeB-like, N-term conserved region Thr_synth_N PF14821.6 PIK42148.1 - 1.6e-23 82.7 0.0 4.4e-23 81.3 0.0 1.7 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 PIK42148.1 - 0.0016 17.9 0.0 0.0019 17.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glyco_transf_56 PF07429.11 PIK42148.1 - 0.2 10.7 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 PALP PF00291.25 PIK42149.1 - 0.0031 17.0 0.0 0.0097 15.3 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ROK PF00480.20 PIK42150.1 - 7.4e-27 94.6 0.2 9.1e-27 94.3 0.2 1.0 1 0 0 1 1 1 1 ROK family Epimerase_2 PF02350.19 PIK42151.1 - 2.9e-57 194.1 0.2 1e-56 192.3 0.1 1.7 1 1 1 2 2 2 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.20 PIK42151.1 - 1.4e-05 24.8 0.0 2.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 ROK family DRTGG PF07085.12 PIK42151.1 - 0.005 16.6 0.2 0.011 15.5 0.2 1.6 1 0 0 1 1 1 1 DRTGG domain Hexokinase_1 PF00349.21 PIK42151.1 - 0.023 14.6 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 Hexokinase FGGY_N PF00370.21 PIK42151.1 - 0.023 14.2 0.0 0.079 12.5 0.0 1.9 2 1 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain Sulfotransfer_1 PF00685.27 PIK42152.1 - 2.1e-44 152.0 0.2 8.3e-38 130.4 0.1 2.1 1 1 1 2 2 2 2 Sulfotransferase domain BNR_2 PF13088.6 PIK42153.1 - 1e-15 57.8 0.0 2.4e-15 56.6 0.0 1.5 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK42153.1 - 2.3e-05 23.7 0.8 0.021 14.7 0.2 2.7 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_6 PF15899.5 PIK42153.1 - 0.13 12.4 1.7 5.5 7.3 0.0 2.6 2 0 0 2 2 2 0 BNR-Asp box repeat LEA_1 PF03760.15 PIK42155.1 - 0.24 12.1 6.9 3.3 8.4 0.2 2.7 2 1 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 CCSAP PF15748.5 PIK42155.1 - 2.7 8.1 22.1 2.3 8.4 9.7 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated OTU PF02338.19 PIK42156.1 - 8.8e-10 39.2 0.0 2.4e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease ubiquitin PF00240.23 PIK42157.1 - 0.00033 20.3 0.1 0.0009 18.9 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin family UDPGP PF01704.18 PIK42160.1 - 0.0081 14.8 0.0 0.0094 14.6 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Ribosomal_S17_N PF16205.5 PIK42161.1 - 4.1e-32 110.4 1.1 7.7e-32 109.5 0.6 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 PIK42161.1 - 3.8e-27 94.2 0.6 6.8e-27 93.4 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S21 PF01165.20 PIK42162.1 - 8.3e-11 41.4 0.7 8.3e-11 41.4 0.7 1.5 2 0 0 2 2 2 1 Ribosomal protein S21 WD40 PF00400.32 PIK42164.1 - 7.5e-60 197.5 32.9 2.9e-09 37.4 0.1 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK42164.1 - 3.8e-24 84.8 7.5 6.2e-05 23.2 0.7 6.4 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK42164.1 - 3.5e-08 32.8 0.4 0.013 14.4 0.0 4.3 3 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 PIK42164.1 - 1.2e-05 23.9 0.0 0.1 10.9 0.0 3.1 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 PIK42164.1 - 2.2e-05 23.4 3.0 1.8 7.1 0.0 4.6 3 2 2 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK42164.1 - 5e-05 23.3 0.0 1.6 8.6 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 PIK42164.1 - 0.00035 20.4 0.9 16 5.6 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 PIK42164.1 - 0.0023 17.3 0.0 2.1 7.6 0.0 3.3 3 0 0 3 3 3 1 WD40-like domain TRAP-delta PF05404.12 PIK42164.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.7 1 0 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) eRF1_1 PF03463.15 PIK42165.1 - 2.9e-45 153.4 0.0 4.8e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 PIK42165.1 - 3.4e-32 111.5 0.2 5.8e-32 110.8 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 PIK42165.1 - 1.1e-16 61.4 0.0 2.9e-16 59.9 0.0 1.8 1 1 1 2 2 2 1 eRF1 domain 3 Ion_trans PF00520.31 PIK42166.1 - 6.6e-16 58.3 1.3 7.9e-16 58.0 1.3 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK42166.1 - 0.0066 16.4 4.0 0.0066 16.4 4.0 2.6 2 2 0 2 2 2 1 Ion channel DUF1445 PF07286.12 PIK42168.1 - 9.2e-38 129.4 0.0 3.2e-37 127.7 0.0 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1445) DUF5044 PF16447.5 PIK42168.1 - 0.0097 15.7 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5044) V-set PF07686.17 PIK42169.1 - 0.00095 19.3 0.1 0.0019 18.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42169.1 - 0.013 16.1 0.1 0.013 16.1 0.1 2.5 3 0 0 3 3 3 0 Immunoglobulin domain Arena_ncap_C PF17290.2 PIK42169.1 - 0.14 11.5 0.1 13 5.0 0.0 2.4 2 1 0 2 2 2 0 Arenavirus nucleocapsid C-terminal domain Tme5_EGF_like PF09064.10 PIK42169.1 - 0.35 10.8 10.3 2.7 7.9 1.7 3.0 2 2 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Fibrinogen_C PF00147.18 PIK42170.1 - 2.9e-31 109.0 1.3 3.4e-31 108.8 1.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42171.1 - 9.7e-63 211.9 3.7 1.2e-62 211.7 3.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42172.1 - 8.2e-38 130.4 1.2 1.2e-37 129.8 1.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIR PF01582.20 PIK42173.1 - 1.4e-19 70.6 1.0 1.7e-19 70.3 1.0 1.1 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK42173.1 - 7.5e-13 49.1 0.1 9.4e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 PIK42173.1 - 7.9e-07 29.4 0.3 1.2e-06 28.9 0.3 1.2 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Fibrinogen_C PF00147.18 PIK42174.1 - 8.9e-19 68.2 2.9 1.1e-18 67.9 2.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42175.1 - 8.7e-56 189.2 3.3 2.9e-50 171.1 3.8 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42176.1 - 8.9e-103 342.8 11.1 4.2e-67 226.2 4.2 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK42176.1 - 0.00013 21.4 1.0 0.25 10.6 0.1 2.2 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain Fibrinogen_C PF00147.18 PIK42177.1 - 4.8e-61 206.4 4.8 6.4e-61 206.0 4.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK42177.1 - 0.00019 21.6 5.4 0.00019 21.6 5.4 2.1 2 0 0 2 2 2 1 EGF domain EGF PF00008.27 PIK42177.1 - 1.7 9.0 6.5 6.8 7.1 6.5 2.1 1 1 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK42178.1 - 1.6e-22 80.4 0.2 2.6e-22 79.7 0.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK42178.1 - 0.006 16.8 3.7 0.006 16.8 3.7 2.8 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK42178.1 - 0.012 15.6 6.9 0.031 14.2 6.9 1.8 1 0 0 1 1 1 0 TILa domain EGF_2 PF07974.13 PIK42178.1 - 0.28 11.6 13.3 0.055 13.8 7.1 2.7 2 1 0 2 2 2 0 EGF-like domain EGF PF00008.27 PIK42178.1 - 2.4 8.5 9.2 2.1 8.7 6.2 2.5 2 1 0 2 2 2 0 EGF-like domain EGF_CA PF07645.15 PIK42178.1 - 4.1 7.7 11.7 1.9 8.8 3.7 2.8 2 0 0 2 2 2 0 Calcium-binding EGF domain Fibrinogen_C PF00147.18 PIK42179.1 - 1.7e-36 126.1 10.8 2.1e-36 125.8 10.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Phage_holin_3_6 PF07332.11 PIK42180.1 - 0.001 19.1 0.2 0.0016 18.5 0.2 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III OAD_gamma PF04277.13 PIK42180.1 - 0.0026 18.3 0.3 0.0047 17.5 0.3 1.4 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain OSTbeta PF15048.6 PIK42180.1 - 0.026 14.7 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Ig_3 PF13927.6 PIK42180.1 - 0.044 14.4 4.7 8.6 7.0 0.0 4.0 4 1 1 5 5 5 0 Immunoglobulin domain DUF1218 PF06749.12 PIK42180.1 - 0.057 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) RSN1_TM PF13967.6 PIK42180.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Baculo_11_kDa PF06143.11 PIK42180.1 - 0.072 12.7 1.0 0.15 11.6 1.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family I-set PF07679.16 PIK42180.1 - 0.085 12.9 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin I-set domain EphA2_TM PF14575.6 PIK42180.1 - 0.1 13.5 0.0 0.21 12.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TM_helix PF05552.12 PIK42180.1 - 2.2 8.3 7.0 4.1 7.5 7.0 1.4 1 0 0 1 1 1 0 Conserved TM helix zf-Di19 PF05605.12 PIK42181.1 - 0.016 15.5 0.2 0.026 14.8 0.2 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.14 PIK42181.1 - 0.029 14.3 0.4 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-C2H2_12 PF18112.1 PIK42181.1 - 0.056 13.9 0.2 0.1 13.0 0.2 1.4 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain Shisa PF13908.6 PIK42182.1 - 0.00018 21.8 1.7 0.00023 21.5 0.2 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator OAD_gamma PF04277.13 PIK42182.1 - 0.00047 20.7 0.2 0.00081 19.9 0.2 1.4 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain Phage_holin_3_6 PF07332.11 PIK42182.1 - 0.00072 19.6 0.1 0.0011 18.9 0.1 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III C2-set_2 PF08205.12 PIK42182.1 - 0.0017 18.4 5.3 0.0024 17.9 0.1 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK42182.1 - 0.0023 18.5 11.3 0.4 11.3 0.1 4.5 4 1 1 5 5 5 2 Immunoglobulin domain OSTbeta PF15048.6 PIK42182.1 - 0.0029 17.7 0.0 0.005 17.0 0.0 1.3 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein EphA2_TM PF14575.6 PIK42182.1 - 0.0091 16.9 0.1 0.019 15.8 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain I-set PF07679.16 PIK42182.1 - 0.034 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF3619 PF12279.8 PIK42182.1 - 0.044 14.1 0.1 0.077 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Baculo_11_kDa PF06143.11 PIK42182.1 - 0.063 12.8 2.6 0.13 11.9 2.6 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF3357 PF11837.8 PIK42182.1 - 0.097 13.1 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Vpu PF00558.19 PIK42182.1 - 0.12 12.2 0.2 0.22 11.3 0.2 1.4 1 0 0 1 1 1 0 Vpu protein RIFIN PF02009.16 PIK42182.1 - 2.6 7.9 4.8 3.1 7.6 3.6 1.7 2 0 0 2 2 2 0 Rifin DUF1180 PF06679.12 PIK42182.1 - 6.1 7.2 6.9 3.2 8.1 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) DUF4686 PF15742.5 PIK42183.1 - 1.9e-15 56.9 71.5 1.9e-15 56.9 71.5 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4686) Spc7 PF08317.11 PIK42183.1 - 0.0037 16.2 10.6 0.0037 16.2 10.6 4.7 1 1 4 5 5 5 2 Spc7 kinetochore protein Toprim PF01751.22 PIK42183.1 - 0.32 11.3 1.9 2 8.7 0.1 2.9 3 0 0 3 3 3 0 Toprim domain Acyl-CoA_dh_2 PF08028.11 PIK42183.1 - 0.57 10.5 8.0 2.4 8.5 1.5 3.1 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain Phage_int_SAM_1 PF02899.17 PIK42185.1 - 8.1e-05 22.9 1.0 0.0002 21.6 0.1 1.9 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK42185.1 - 0.00031 21.2 0.0 0.00053 20.4 0.0 1.3 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain RT_RNaseH PF17917.1 PIK42186.1 - 4.7e-05 23.6 0.1 0.00032 20.9 0.1 2.0 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK42186.1 - 0.024 14.7 0.0 0.27 11.3 0.0 2.1 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase AAA_11 PF13086.6 PIK42188.1 - 6.6e-27 94.9 0.0 1.2e-26 94.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK42188.1 - 1.9e-12 47.3 0.0 3.5e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK42188.1 - 8.2e-09 36.0 0.0 1.6e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK42188.1 - 1.2e-05 25.6 0.0 0.00017 21.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK42188.1 - 0.00013 22.4 0.1 0.00044 20.7 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain Flavi_DEAD PF07652.14 PIK42188.1 - 0.0003 20.8 0.1 0.00057 19.9 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA PF00004.29 PIK42188.1 - 0.00042 20.7 0.0 0.001 19.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 PIK42188.1 - 0.00075 18.6 0.0 0.002 17.2 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein PhoH PF02562.16 PIK42188.1 - 0.001 18.6 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DnaB_C PF03796.15 PIK42188.1 - 0.0016 17.9 0.0 0.0071 15.7 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Helicase_RecD PF05127.14 PIK42188.1 - 0.0021 17.9 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 Helicase IstB_IS21 PF01695.17 PIK42188.1 - 0.0024 17.6 0.0 0.0057 16.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 PIK42188.1 - 0.0057 16.7 0.0 0.0099 15.9 0.0 1.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK42188.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase cobW PF02492.19 PIK42188.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 PIK42188.1 - 0.013 15.5 0.1 0.063 13.2 0.0 1.9 1 1 1 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 PIK42188.1 - 0.015 15.2 1.9 0.027 14.4 0.4 2.2 2 1 1 3 3 3 0 NTPase AAA_33 PF13671.6 PIK42188.1 - 0.018 15.2 0.0 0.056 13.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 PIK42188.1 - 0.019 14.7 0.2 0.036 13.8 0.1 1.5 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 PIK42188.1 - 0.02 15.4 0.0 0.46 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 PIK42188.1 - 0.021 14.6 0.0 0.059 13.1 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Zot PF05707.12 PIK42188.1 - 0.021 14.5 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_25 PF13481.6 PIK42188.1 - 0.026 14.1 0.0 0.05 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 PIK42188.1 - 0.027 13.7 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 PIK42188.1 - 0.03 14.3 0.0 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Herpes_Helicase PF02689.14 PIK42188.1 - 0.032 12.2 0.0 0.042 11.8 0.0 1.1 1 0 0 1 1 1 0 Helicase CbiA PF01656.23 PIK42188.1 - 0.032 14.3 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Herpes_ori_bp PF02399.15 PIK42188.1 - 0.032 12.3 0.0 0.044 11.8 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein UvrD-helicase PF00580.21 PIK42188.1 - 0.043 13.3 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ATPase PF06745.13 PIK42188.1 - 0.047 13.0 0.0 0.11 11.8 0.0 1.5 2 0 0 2 2 2 0 KaiC HEM4 PF02602.15 PIK42188.1 - 0.073 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD DAP3 PF10236.9 PIK42188.1 - 0.074 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.13 PIK42188.1 - 0.094 11.9 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_6 PF12774.7 PIK42188.1 - 0.098 11.6 0.1 0.22 10.5 0.0 1.5 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region ABC_tran PF00005.27 PIK42188.1 - 0.099 13.2 0.0 0.25 11.8 0.0 1.6 2 0 0 2 2 1 0 ABC transporter AAA_7 PF12775.7 PIK42188.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 PIK42188.1 - 0.17 11.6 0.0 0.8 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 PIK42188.1 - 0.18 12.1 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ephrin PF00812.17 PIK42189.1 - 0.0034 17.4 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 Ephrin E3_UbLigase_RBR PF18091.1 PIK42189.1 - 0.1 12.7 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 E3 Ubiquitin Ligase RBR C-terminal domain VWC PF00093.18 PIK42190.1 - 3.3e-06 27.3 13.9 3.3e-06 27.3 13.9 2.2 4 0 0 4 4 4 1 von Willebrand factor type C domain VWC PF00093.18 PIK42191.1 - 2.5e-05 24.5 13.1 2.5e-05 24.5 13.1 2.3 2 0 0 2 2 2 1 von Willebrand factor type C domain TILa PF12714.7 PIK42191.1 - 9 6.3 17.2 11 6.1 12.6 2.6 2 0 0 2 2 2 0 TILa domain VWC PF00093.18 PIK42192.1 - 3.4e-06 27.3 13.1 3.4e-06 27.3 13.1 3.2 3 0 0 3 3 3 1 von Willebrand factor type C domain TILa PF12714.7 PIK42192.1 - 0.12 12.3 13.9 0.072 13.1 5.8 3.1 3 0 0 3 3 3 0 TILa domain Adeno_IVa2 PF02456.15 PIK42193.1 - 8.1e-07 28.2 0.0 2e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 Adenovirus IVa2 protein Pox_A32 PF04665.12 PIK42193.1 - 1.6e-06 27.7 0.0 0.022 14.2 0.0 2.1 2 0 0 2 2 2 2 Poxvirus A32 protein AAA_14 PF13173.6 PIK42193.1 - 6.5e-05 23.0 0.0 0.00019 21.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain NB-ARC PF00931.22 PIK42193.1 - 0.0031 16.7 0.0 0.048 12.9 0.0 2.0 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK42193.1 - 0.0083 16.4 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 PIK42193.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 PIK42193.1 - 0.015 15.7 0.0 0.035 14.5 0.0 1.7 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 PIK42193.1 - 0.021 14.7 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 PIK42193.1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.5 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 PIK42193.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PRTase_3 PF15610.6 PIK42193.1 - 0.033 13.4 0.2 0.073 12.3 0.2 1.5 1 1 0 1 1 1 0 PRTase ComF-like AAA_19 PF13245.6 PIK42193.1 - 0.034 14.5 0.0 0.037 14.4 0.0 1.3 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK42193.1 - 0.034 14.5 0.0 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 PIK42193.1 - 0.041 13.4 0.1 0.073 12.6 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 PIK42193.1 - 0.054 13.9 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 PIK42193.1 - 0.06 12.8 0.0 0.088 12.3 0.0 1.4 1 1 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 PIK42193.1 - 0.084 13.4 0.1 0.12 12.9 0.1 1.6 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 PIK42193.1 - 0.13 11.1 0.0 0.41 9.5 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 PIK42193.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 PIK42193.1 - 0.15 11.3 0.0 0.34 10.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.18 PIK42193.1 - 0.16 11.3 0.0 1.4 8.2 0.0 2.2 2 1 1 3 3 3 0 FtsK/SpoIIIE family BTB PF00651.31 PIK42194.1 - 3.1e-17 62.8 0.0 1.5e-16 60.6 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain CID_GANP PF16766.5 PIK42194.1 - 0.048 13.9 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Binding region of GANP to ENY2 BACK PF07707.15 PIK42194.1 - 0.12 12.5 0.5 9.5 6.4 0.1 3.4 3 0 0 3 3 3 0 BTB And C-terminal Kelch Endosulfine PF04667.17 PIK42195.1 - 1.4e-12 47.5 0.8 2.4e-12 46.8 0.6 1.5 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region TraT PF05818.12 PIK42196.1 - 3.3 7.3 9.7 0.15 11.7 2.5 2.0 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein EGF PF00008.27 PIK42197.1 - 7.6e-61 202.0 196.5 1.4e-08 34.9 1.7 13.3 13 0 0 13 13 12 12 EGF-like domain hEGF PF12661.7 PIK42197.1 - 8.9e-29 99.1 165.4 0.00059 20.4 6.4 14.0 13 0 0 13 13 12 10 Human growth factor-like EGF EGF_CA PF07645.15 PIK42197.1 - 6.1e-16 58.3 228.6 2.2e-05 24.5 4.6 14.4 8 4 6 14 14 13 11 Calcium-binding EGF domain ShK PF01549.24 PIK42197.1 - 3e-09 37.3 18.3 8.8e-06 26.2 4.9 9.1 8 2 1 9 9 3 2 ShK domain-like EGF_2 PF07974.13 PIK42197.1 - 2.1e-08 34.4 230.1 0.025 15.0 12.5 13.3 13 1 0 13 13 12 9 EGF-like domain EGF_3 PF12947.7 PIK42197.1 - 0.00069 19.8 22.6 0.0019 18.4 12.2 13.5 10 1 3 13 13 13 5 EGF domain DUF2207 PF09972.9 PIK42197.1 - 0.0036 16.1 3.7 0.0053 15.6 3.7 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 PIK42197.1 - 0.0076 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 Orf78 (ac78) Endomucin PF07010.12 PIK42197.1 - 0.024 14.6 45.7 0.038 14.0 45.7 1.2 1 0 0 1 1 1 0 Endomucin DUF2970 PF11174.8 PIK42197.1 - 0.078 12.8 0.8 0.13 12.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) DUF975 PF06161.11 PIK42197.1 - 0.097 12.4 0.6 0.15 11.8 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF975) ABC2_membrane_3 PF12698.7 PIK42197.1 - 0.53 9.3 4.3 0.84 8.7 4.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein MAM PF00629.23 PIK42198.1 - 9.4e-28 97.2 0.0 5.1e-13 49.3 0.0 2.0 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu NUDIX PF00293.28 PIK42199.1 - 1.1e-07 32.0 0.6 1.7e-07 31.4 0.6 1.2 1 0 0 1 1 1 1 NUDIX domain TRPM_tetra PF16519.5 PIK42200.1 - 9.7e-09 35.2 0.9 2.9e-08 33.7 0.9 1.9 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 PIK42200.1 - 0.00042 19.6 0.7 0.00075 18.8 0.7 1.3 1 0 0 1 1 1 1 Ion transport protein Collagen PF01391.18 PIK42201.1 - 6.2e-06 25.9 13.4 6.2e-06 25.9 13.4 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK42202.1 - 3.2e-06 26.8 13.4 6.5e-06 25.8 13.4 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) GP38 PF05268.11 PIK42202.1 - 0.034 13.8 1.9 0.056 13.1 1.9 1.3 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 LSDAT_euk PF18139.1 PIK42203.1 - 5.1e-86 288.4 0.0 8e-86 287.7 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 PIK42203.1 - 6.1e-18 64.8 0.0 1.2e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ank_2 PF12796.7 PIK42203.1 - 0.019 15.6 0.3 10 6.8 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) S-antigen PF05756.11 PIK42203.1 - 6.9 7.1 6.2 8.1 6.9 0.2 2.8 3 0 0 3 3 3 0 S-antigen protein UQ_con PF00179.26 PIK42204.1 - 1.8e-11 43.9 0.0 3e-10 39.9 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Cnd2 PF05786.14 PIK42204.1 - 0.061 12.0 8.5 0.082 11.6 8.5 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Josephin PF02099.17 PIK42204.1 - 0.084 13.0 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Josephin zf-B_box PF00643.24 PIK42205.1 - 1.9e-10 40.7 5.9 3.4e-10 39.9 5.9 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF424 PF04242.13 PIK42205.1 - 0.0035 17.6 1.3 0.0052 17.0 0.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF424) DUF4456 PF14644.6 PIK42205.1 - 0.017 14.8 2.5 0.1 12.3 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) DUF349 PF03993.12 PIK42205.1 - 5.2 7.4 6.8 12 6.3 1.3 2.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) PapD-like PF14874.6 PIK42206.1 - 1.8e-13 50.5 0.0 3.3e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 Flagellar-associated PapD-like ERAP1_C PF11838.8 PIK42207.1 - 1.7e-46 159.3 0.3 7.5e-44 150.5 0.1 2.3 1 1 1 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 PIK42207.1 - 1.4e-20 73.9 0.1 2.9e-20 72.8 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain Folliculin PF11704.8 PIK42209.1 - 3.1e-06 27.2 1.0 6.9e-06 26.1 1.0 1.8 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Cbl_N PF02262.16 PIK42209.1 - 0.024 14.6 0.3 0.23 11.5 0.1 2.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 Cnn_1N PF07989.11 PIK42210.1 - 4 7.7 17.1 0.14 12.4 8.2 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Taxilin PF09728.9 PIK42211.1 - 1.5e-96 323.2 66.7 1.3e-63 215.1 39.9 2.9 2 1 1 3 3 3 2 Myosin-like coiled-coil protein PIN_10 PF18478.1 PIK42211.1 - 0.097 12.9 0.4 2 8.7 0.0 2.5 2 0 0 2 2 2 0 PIN like domain DUF4342 PF14242.6 PIK42211.1 - 5 7.2 5.5 1.6 8.8 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) PNISR PF15996.5 PIK42212.1 - 2.3e-40 139.0 15.6 2.3e-40 139.0 15.6 6.2 3 1 3 6 6 6 1 Arginine/serine-rich protein PNISR Methyltransf_23 PF13489.6 PIK42213.1 - 7.4e-22 77.9 0.0 9.9e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK42213.1 - 5.2e-21 75.1 0.1 7.8e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK42213.1 - 7e-17 61.9 0.1 1.6e-16 60.8 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK42213.1 - 2.4e-15 57.1 0.0 4e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK42213.1 - 1.3e-13 51.0 0.0 1.7e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK42213.1 - 2.5e-09 36.9 0.0 3.5e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 PIK42213.1 - 3.2e-08 33.2 0.0 4.2e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 PIK42213.1 - 7.5e-07 28.7 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 PIK42213.1 - 0.00011 22.3 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 PIK42213.1 - 0.00027 20.6 0.0 0.00051 19.7 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 PIK42213.1 - 0.0024 17.4 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 PIK42213.1 - 0.011 15.4 0.2 0.022 14.4 0.2 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW TehB PF03848.14 PIK42213.1 - 0.022 14.2 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 PIK42213.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 PIK42213.1 - 0.083 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) RrnaAD PF00398.20 PIK42213.1 - 0.098 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Rossmann-like PF10727.9 PIK42213.1 - 0.17 11.7 0.7 0.28 11.1 0.7 1.4 1 1 0 1 1 1 0 Rossmann-like domain CMS1 PF14617.6 PIK42214.1 - 3.2e-29 102.0 2.1 4.2e-29 101.6 2.1 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 PIK42214.1 - 5.3e-05 23.0 0.0 8.3e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Nop14 PF04147.12 PIK42214.1 - 0.00043 18.7 2.2 0.00051 18.4 2.2 1.0 1 0 0 1 1 1 1 Nop14-like family Pkinase_Tyr PF07714.17 PIK42215.1 - 3.2e-35 121.7 0.0 4.2e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42215.1 - 5.6e-13 48.9 0.0 7e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TPR_1 PF00515.28 PIK42216.1 - 1.7e-41 138.3 9.4 1.6e-06 27.7 0.1 11.9 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_2 PF07719.17 PIK42216.1 - 3.4e-40 132.9 0.1 0.00017 21.5 0.0 12.0 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_12 PF13424.6 PIK42216.1 - 9.8e-30 102.7 0.1 4.2e-08 33.4 0.0 8.7 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 PIK42216.1 - 2.8e-24 84.1 4.6 0.0024 18.4 0.0 10.7 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK42216.1 - 9.3e-22 75.4 8.4 0.0031 17.4 0.0 11.1 13 0 0 13 13 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42216.1 - 2.2e-21 74.2 24.4 0.0023 18.0 0.0 12.7 14 0 0 14 14 13 5 Tetratricopeptide repeat TPR_19 PF14559.6 PIK42216.1 - 2.1e-18 66.5 0.0 0.0052 17.3 0.0 7.2 6 2 2 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK42216.1 - 1.1e-13 51.2 13.0 0.00087 19.5 0.2 6.3 4 1 1 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 PIK42216.1 - 6.4e-13 49.1 0.0 0.01 16.5 0.0 6.7 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK42216.1 - 1e-11 44.3 2.0 0.08 12.6 0.1 7.8 6 2 3 9 9 9 2 TPR repeat TPR_14 PF13428.6 PIK42216.1 - 1.3e-11 44.3 0.0 0.6 11.1 0.0 9.0 5 3 4 10 10 8 1 Tetratricopeptide repeat SNAP PF14938.6 PIK42216.1 - 1.7e-09 37.6 13.9 7.2e-08 32.2 0.2 5.1 2 2 2 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 PIK42216.1 - 4.9e-08 32.8 2.5 7.2 7.2 0.0 7.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK42216.1 - 9e-07 29.0 0.0 0.33 11.1 0.0 5.1 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK42216.1 - 1.8e-06 27.6 2.9 0.44 10.5 0.0 7.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK42216.1 - 2.6e-05 24.0 4.2 0.0039 16.9 0.4 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 PIK42216.1 - 0.00023 20.5 1.7 0.019 14.2 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK42216.1 - 0.00085 19.3 4.7 16 5.6 0.1 6.3 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 PIK42216.1 - 0.0088 16.7 4.3 6.9 7.5 0.1 4.7 4 0 0 4 4 4 1 Sel1 repeat TPR_MalT PF17874.1 PIK42216.1 - 0.039 13.3 0.1 7.3 5.9 0.0 4.0 3 1 2 6 6 6 0 MalT-like TPR region Wzy_C_2 PF11846.8 PIK42216.1 - 0.075 12.9 0.1 11 5.9 0.0 3.5 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal Lipin_mid PF16876.5 PIK42216.1 - 0.15 12.2 0.4 0.47 10.6 0.4 1.9 1 0 0 1 1 1 0 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF2225 PF09986.9 PIK42216.1 - 0.39 10.4 12.1 0.84 9.3 1.7 4.1 2 2 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 PIK42216.1 - 4.2 7.4 15.9 7 6.8 0.1 6.5 7 1 1 8 8 7 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK42216.1 - 4.8 6.9 14.5 0.07 12.8 1.2 4.4 5 2 1 6 6 6 0 26S proteasome subunit RPN7 Pkinase_Tyr PF07714.17 PIK42217.1 - 2.9e-58 197.2 0.0 3.6e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42217.1 - 1.6e-55 188.4 0.0 2.2e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 PIK42217.1 - 0.033 14.1 0.0 0.12 12.2 0.0 1.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family TauD PF02668.16 PIK42218.1 - 1.6e-31 110.1 0.0 3.9e-30 105.5 0.0 2.0 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK42218.1 - 8.6e-09 35.9 0.2 8.5e-08 32.7 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF971) CsiD PF08943.10 PIK42218.1 - 0.0042 16.3 0.0 0.006 15.7 0.0 1.3 1 0 0 1 1 1 1 CsiD Fibrinogen_C PF00147.18 PIK42219.1 - 2.5e-26 92.9 2.7 2.8e-26 92.7 2.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42220.1 - 6.4e-67 225.6 6.2 7.6e-67 225.3 6.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK42220.1 - 0.00017 21.0 0.1 0.00029 20.2 0.1 1.5 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain p450 PF00067.22 PIK42221.1 - 2.8e-82 276.9 0.8 3.6e-82 276.6 0.8 1.0 1 0 0 1 1 1 1 Cytochrome P450 CheZ PF04344.13 PIK42221.1 - 0.11 12.4 0.4 0.19 11.6 0.4 1.3 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ p450 PF00067.22 PIK42222.1 - 6.2e-41 140.6 0.1 7.4e-41 140.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lectin_C PF00059.21 PIK42223.1 - 1e-12 48.7 0.5 3.5e-12 47.0 0.5 1.7 1 1 0 1 1 1 1 Lectin C-type domain Sec23_trunk PF04811.15 PIK42224.1 - 8e-78 261.4 0.0 1.1e-77 260.9 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 PIK42224.1 - 2.5e-32 111.5 0.1 6.2e-32 110.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 PIK42224.1 - 2.2e-25 88.5 0.1 5.3e-25 87.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 PIK42224.1 - 2.8e-16 59.3 7.8 5.7e-16 58.3 7.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 PIK42224.1 - 3.6e-14 52.4 0.1 9e-14 51.1 0.1 1.7 1 0 0 1 1 1 1 Gelsolin repeat Spc7 PF08317.11 PIK42225.1 - 0.00093 18.2 23.8 0.00093 18.2 23.8 7.8 1 1 7 8 8 8 5 Spc7 kinetochore protein AAA_13 PF13166.6 PIK42225.1 - 0.0013 17.5 30.4 0.0013 17.5 30.4 4.8 1 1 2 4 4 4 1 AAA domain DUF3584 PF12128.8 PIK42225.1 - 0.38 8.2 149.9 0.024 12.2 57.2 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF3584) KAR9 PF08580.10 PIK42226.1 - 0.07 11.7 3.1 0.077 11.5 3.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 FKBP_C PF00254.28 PIK42227.1 - 5.3e-33 113.2 0.0 1.1e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RVT_1 PF00078.27 PIK42227.1 - 3.1e-31 108.6 0.8 6.1e-31 107.7 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK42227.1 - 6.5e-10 38.4 0.0 1.5e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) ASFV_J13L PF05568.11 PIK42227.1 - 0.27 11.0 0.4 0.4 10.4 0.4 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein FA_desaturase PF00487.24 PIK42228.1 - 1.2e-10 41.7 3.7 1.4e-10 41.4 3.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase PH PF00169.29 PIK42229.1 - 7.7e-16 58.5 1.7 7.7e-16 58.5 1.7 1.6 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 PIK42229.1 - 1e-06 28.9 0.8 1.5e-06 28.4 0.8 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 PIK42229.1 - 1.8e-06 28.0 0.2 2.7e-06 27.4 0.2 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK42229.1 - 3.5e-05 24.2 9.6 0.00029 21.2 7.0 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 PIK42229.1 - 0.025 14.9 0.4 0.04 14.3 0.4 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_6 PF15406.6 PIK42229.1 - 0.028 14.7 0.1 0.059 13.7 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain MyTH4 PF00784.17 PIK42230.1 - 4.4e-31 107.6 1.1 8.9e-31 106.6 1.1 1.5 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 PIK42230.1 - 1.3e-15 57.8 0.2 2.2e-14 53.9 0.0 2.7 3 0 0 3 3 3 1 FERM central domain PH PF00169.29 PIK42230.1 - 1.1e-09 38.7 0.2 3.5e-09 37.1 0.2 1.9 1 0 0 1 1 1 1 PH domain MoCF_biosynth PF00994.24 PIK42231.1 - 6.4e-49 165.3 0.4 3.5e-32 111.1 0.0 3.0 3 0 0 3 3 3 2 Probable molybdopterin binding domain MoeA_N PF03453.17 PIK42231.1 - 3.6e-46 156.8 0.7 6.6e-46 155.9 0.7 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 PIK42231.1 - 1.6e-10 41.0 0.0 3.3e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) YBD PF17725.1 PIK42231.1 - 0.072 13.0 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 YAP binding domain Sec23_BS PF08033.12 PIK42232.1 - 1e-05 26.2 0.6 2.7e-05 24.8 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_trunk PF04811.15 PIK42232.1 - 0.0014 18.3 0.2 2.3 7.7 0.0 2.9 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain VWA PF00092.28 PIK42232.1 - 0.0094 16.2 0.0 0.048 13.9 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain Ras PF00071.22 PIK42233.1 - 2.3e-13 50.1 0.9 7.2e-09 35.5 0.0 2.6 3 0 0 3 3 3 2 Ras family zf-Sec23_Sec24 PF04810.15 PIK42233.1 - 1.3e-06 28.3 0.8 2.6e-06 27.4 0.8 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Roc PF08477.13 PIK42233.1 - 1.6e-06 28.3 0.0 3.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 PIK42233.1 - 0.00041 20.6 0.0 0.00067 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.17 PIK42233.1 - 0.013 15.6 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 PIK42233.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 PIK42233.1 - 0.077 13.1 0.1 0.15 12.2 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase PHD PF00628.29 PIK42233.1 - 0.3 11.0 4.7 0.085 12.8 1.6 1.7 2 0 0 2 2 2 0 PHD-finger Ras PF00071.22 PIK42234.1 - 7.6e-15 54.9 0.0 7.9e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK42234.1 - 4.8e-08 33.3 0.0 4.8e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK42235.1 - 1.5e-20 73.4 0.0 1.9e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Ras family VWA_2 PF13519.6 PIK42236.1 - 1.5e-05 25.5 0.0 0.07 13.8 0.0 3.5 2 1 1 3 3 3 2 von Willebrand factor type A domain Sec23_BS PF08033.12 PIK42236.1 - 2.9e-05 24.7 0.6 6.8e-05 23.5 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 PIK42236.1 - 8.6e-05 22.5 0.5 0.00024 21.1 0.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.15 PIK42236.1 - 0.00066 19.3 0.2 1.3 8.5 0.0 2.7 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain VWA PF00092.28 PIK42236.1 - 0.00095 19.5 0.5 0.012 15.9 0.0 2.6 2 1 1 3 3 3 1 von Willebrand factor type A domain ANF_receptor PF01094.28 PIK42237.1 - 8.8e-07 28.3 0.0 1.2e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region ANF_receptor PF01094.28 PIK42238.1 - 1.6e-14 53.8 0.0 2.4e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lectin_C PF00059.21 PIK42238.1 - 0.0016 19.1 0.0 0.0031 18.2 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain 7tm_3 PF00003.22 PIK42239.1 - 1.9e-17 63.8 19.6 1.2e-07 31.8 5.1 3.1 1 1 2 3 3 3 3 7 transmembrane sweet-taste receptor of 3 GCPR Peptidase_C14 PF00656.22 PIK42240.1 - 2.8e-51 174.9 0.0 3.2e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Caspase domain GST_C_3 PF14497.6 PIK42242.1 - 1.5e-07 31.5 0.0 2.3e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK42242.1 - 5.1e-06 26.6 0.0 7.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK42242.1 - 0.00052 20.3 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK42242.1 - 0.013 15.5 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 PIK42242.1 - 0.029 15.1 0.0 0.072 13.8 0.0 1.7 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain Xpo1 PF08389.12 PIK42242.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 Exportin 1-like protein GST_N_3 PF13417.6 PIK42242.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GPS PF01825.21 PIK42244.1 - 2.4e-13 50.4 3.1 4.1e-13 49.6 3.1 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK42244.1 - 9.3e-06 25.2 0.6 1.4e-05 24.7 0.6 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain rve PF00665.26 PIK42245.1 - 2.9e-16 59.7 0.0 5e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK42246.1 - 2.9e-17 63.0 0.0 4.4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK42247.1 - 0.00099 19.1 13.7 0.002 18.1 5.0 2.7 2 0 0 2 2 2 2 Zinc knuckle Zn_ribbon_recom PF13408.6 PIK42247.1 - 6 7.5 16.3 1.8 9.1 13.2 1.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Peptidase_C14 PF00656.22 PIK42248.1 - 1.3e-47 162.9 0.1 1.6e-47 162.6 0.1 1.1 1 0 0 1 1 1 1 Caspase domain DUF2120 PF09893.9 PIK42248.1 - 0.0062 16.7 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2120) HYR PF02494.16 PIK42249.1 - 4.8e-33 113.3 2.2 2.1e-12 47.2 1.9 3.4 3 0 0 3 3 3 3 HYR domain Sushi PF00084.20 PIK42249.1 - 6.2e-11 42.7 34.1 8.7e-06 26.2 6.8 3.7 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) DUF5011 PF16403.5 PIK42249.1 - 0.0012 18.9 1.6 0.23 11.6 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF5011) BclA_C PF18573.1 PIK42249.1 - 1.6 8.7 3.3 5.9 6.8 1.3 2.2 2 0 0 2 2 2 0 BclA C-terminal domain HYR PF02494.16 PIK42250.1 - 4.9e-39 132.5 0.7 1.9e-18 66.5 0.0 3.4 3 0 0 3 3 3 3 HYR domain Sushi PF00084.20 PIK42250.1 - 3e-17 62.9 31.8 3.2e-05 24.4 2.5 4.5 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) Antistasin PF02822.14 PIK42250.1 - 0.19 12.4 15.9 3.9 8.2 0.6 5.3 4 1 0 4 4 4 0 Antistasin family NDK PF00334.19 PIK42251.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Nucleoside diphosphate kinase DNA_gyraseB_C PF00986.21 PIK42251.1 - 0.11 12.8 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 DNA gyrase B subunit, carboxyl terminus SDA1 PF05285.12 PIK42251.1 - 0.26 10.7 11.0 0.35 10.3 11.0 1.1 1 0 0 1 1 1 0 SDA1 Pes-10 PF07149.11 PIK42251.1 - 0.51 9.3 5.9 0.85 8.6 5.9 1.3 1 0 0 1 1 1 0 Pes-10 CDC45 PF02724.14 PIK42251.1 - 0.82 7.9 10.1 1.1 7.5 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 PIK42251.1 - 1.7 8.3 6.9 3 7.5 6.9 1.4 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 PIK42251.1 - 8.7 4.3 12.6 12 3.8 12.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi adh_short PF00106.25 PIK42252.1 - 7.8e-23 81.0 0.0 8.7e-22 77.5 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK42252.1 - 2.8e-08 33.6 0.0 0.00035 20.2 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK42252.1 - 0.0012 18.8 0.0 0.0056 16.6 0.0 1.8 2 0 0 2 2 2 1 KR domain TPR_2 PF07719.17 PIK42254.1 - 0.0026 17.8 0.1 0.013 15.6 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42254.1 - 0.0036 17.1 0.0 0.0064 16.3 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42254.1 - 0.0096 16.1 0.1 0.05 13.8 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK42254.1 - 0.048 13.1 0.2 0.08 12.4 0.2 1.4 1 0 0 1 1 1 0 SHNi-TPR TPR_12 PF13424.6 PIK42254.1 - 0.074 13.4 0.4 0.17 12.2 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK42254.1 - 0.14 13.0 0.2 0.45 11.5 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42255.1 - 8.3e-18 63.1 19.5 0.0064 16.6 0.2 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 PIK42255.1 - 8.1e-15 53.7 18.8 0.0014 18.6 0.1 8.8 10 1 0 10 10 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42255.1 - 2.8e-14 52.2 29.0 9.2e-05 22.1 0.4 8.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 PIK42255.1 - 4.9e-14 52.4 18.4 0.00016 21.9 0.1 6.4 3 1 2 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK42255.1 - 2.2e-09 37.2 0.4 0.00017 21.1 0.3 3.2 1 1 2 3 3 3 2 MalT-like TPR region TPR_14 PF13428.6 PIK42255.1 - 1.1e-06 29.0 4.2 8.1 7.6 0.0 7.5 8 1 2 10 10 9 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK42255.1 - 1.7e-06 27.6 18.3 1.3 9.2 0.0 7.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK42255.1 - 1.1e-05 25.9 0.0 0.27 11.9 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK42255.1 - 0.0014 19.2 22.7 0.22 12.3 0.0 8.1 10 0 0 10 10 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK42255.1 - 0.038 14.2 0.8 0.038 14.2 0.8 5.4 4 3 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK42255.1 - 0.052 13.7 1.7 3.5 7.9 0.0 4.2 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK42255.1 - 0.052 13.2 6.4 1.8 8.3 0.1 4.7 5 1 0 5 5 5 0 TPR repeat PHA_synth_III_E PF09712.10 PIK42255.1 - 0.098 11.7 0.1 0.098 11.7 0.1 1.7 2 0 0 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) CHAT PF12770.7 PIK42256.1 - 1.2e-31 110.2 0.0 3.7e-29 102.0 0.0 2.3 1 1 0 1 1 1 1 CHAT domain Caskin-Pro-rich PF16907.5 PIK42256.1 - 0.34 11.5 7.4 1 10.0 7.4 1.8 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Ribosomal_S2 PF00318.20 PIK42257.1 - 1.7e-34 119.0 0.0 4.3e-18 65.3 0.0 2.1 1 1 0 2 2 2 2 Ribosomal protein S2 Clr2 PF10383.9 PIK42258.1 - 1.3 9.8 6.4 4.4 8.1 6.3 2.1 1 1 0 1 1 1 0 Transcription-silencing protein Clr2 DUF390 PF04094.14 PIK42258.1 - 6.3 5.0 32.4 8.6 4.5 32.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Laminin_EGF PF00053.24 PIK42259.1 - 2.6e-57 190.8 159.6 9.4e-11 41.7 15.2 8.8 9 0 0 9 9 9 8 Laminin EGF domain Laminin_B PF00052.18 PIK42259.1 - 2.9e-14 53.1 0.0 4.1e-07 30.0 0.0 2.4 1 1 1 2 2 2 2 Laminin B (Domain IV) Halogen_Hydrol PF10112.9 PIK42259.1 - 0.23 11.5 7.7 0.14 12.2 0.5 2.2 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein HJURP_mid PF12346.8 PIK42260.1 - 0.65 10.5 3.1 0.98 9.9 2.1 1.8 1 1 1 2 2 2 0 Holliday junction recognition protein-associated repeat Ank_2 PF12796.7 PIK42261.1 - 1.4e-36 125.0 0.1 1.3e-14 54.5 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK42261.1 - 6.5e-27 93.6 2.9 2.7e-09 37.4 0.0 5.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 PIK42261.1 - 7e-23 80.0 0.3 0.00064 20.1 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 PIK42261.1 - 5.9e-21 72.3 1.3 0.0036 17.7 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 PIK42261.1 - 1.9e-18 66.3 10.2 1.3e-05 25.3 0.0 5.6 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Pre-SET PF05033.16 PIK42261.1 - 8.3e-16 58.6 10.4 8.3e-16 58.6 10.4 2.5 2 0 0 2 2 2 1 Pre-SET motif SET PF00856.28 PIK42261.1 - 0.0098 16.3 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 SET domain HECT PF00632.25 PIK42263.1 - 1.4e-50 172.6 0.0 2.2e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ANAPC10 PF03256.16 PIK42263.1 - 6.5e-07 29.2 0.2 1.2e-06 28.3 0.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK42263.1 - 0.00079 19.6 0.0 0.0026 17.9 0.0 1.8 1 0 0 1 1 1 1 F5/8 type C domain Pkinase_Tyr PF07714.17 PIK42264.1 - 6.5e-87 291.1 0.0 1.3e-86 290.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42264.1 - 1.6e-38 132.6 0.0 2.3e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 PIK42264.1 - 8.2e-19 67.7 7.3 2.1e-18 66.4 7.3 1.8 1 0 0 1 1 1 1 Kringle domain Ig_3 PF13927.6 PIK42264.1 - 1.4e-17 64.1 3.5 2.2e-13 50.6 0.1 3.3 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK42264.1 - 5.3e-17 61.7 0.1 9e-12 44.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42264.1 - 2.8e-13 50.0 0.6 9.8e-11 41.8 0.0 3.2 2 1 0 2 2 2 1 Immunoglobulin domain Fz PF01392.22 PIK42264.1 - 1.3e-08 35.4 2.2 1.3e-08 35.4 2.2 2.1 2 0 0 2 2 1 1 Fz domain ig PF00047.25 PIK42264.1 - 4.3e-08 33.2 0.4 7.1e-07 29.3 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK42264.1 - 3.1e-06 27.3 0.0 0.00013 22.1 0.0 2.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK42264.1 - 7.7e-06 25.9 0.4 0.011 15.8 0.0 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 PIK42264.1 - 0.00018 21.7 0.0 0.00047 20.4 0.0 1.7 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK42264.1 - 0.055 13.9 3.9 0.072 13.5 0.0 3.0 3 1 0 3 3 3 0 Immunoglobulin C1-set domain FANCL_C PF11793.8 PIK42264.1 - 2.3 8.4 5.2 0.96 9.7 1.5 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain Phosphodiest PF01663.22 PIK42265.1 - 2.1e-11 44.0 0.0 8.1e-09 35.5 0.0 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 PIK42265.1 - 0.00042 19.8 0.0 0.00067 19.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 PIK42265.1 - 0.0037 16.7 0.0 0.0057 16.1 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Zf_RING PF16744.5 PIK42266.1 - 1.2e-16 60.5 2.5 2e-16 59.8 2.5 1.3 1 0 0 1 1 1 1 KIAA1045 RING finger EF-hand_7 PF13499.6 PIK42266.1 - 3.5e-11 43.4 17.4 2.3e-07 31.2 3.9 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 PIK42266.1 - 1.1e-07 30.8 10.3 0.00033 20.0 0.3 2.9 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK42266.1 - 1.2e-07 31.1 6.3 0.0022 17.8 0.1 2.7 2 1 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK42266.1 - 3.6e-05 23.1 7.8 0.0019 17.6 0.1 3.0 2 1 1 3 3 3 2 EF hand PHD_4 PF16866.5 PIK42266.1 - 0.00039 20.4 3.5 0.0015 18.5 3.5 2.1 1 1 0 1 1 1 1 PHD-finger EF-hand_8 PF13833.6 PIK42266.1 - 0.00043 20.1 6.2 0.0035 17.2 0.1 2.5 2 1 0 2 2 2 1 EF-hand domain pair PHD PF00628.29 PIK42266.1 - 0.00058 19.7 5.3 0.0034 17.2 5.3 2.0 1 1 0 1 1 1 1 PHD-finger Zn_ribbon_17 PF17120.5 PIK42266.1 - 0.0023 17.5 0.7 0.0023 17.5 0.7 1.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-4CXXC_R1 PF10497.9 PIK42266.1 - 0.006 16.8 1.4 0.011 16.0 1.4 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 PHD_Oberon PF07227.11 PIK42266.1 - 0.0089 15.9 1.2 0.014 15.3 1.2 1.3 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein zf-HC5HC2H PF13771.6 PIK42266.1 - 0.015 15.5 2.7 0.031 14.5 2.7 1.6 1 1 0 1 1 1 0 PHD-like zinc-binding domain DUF2430 PF10353.9 PIK42266.1 - 0.052 13.9 0.2 0.11 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) zf-MIZ PF02891.20 PIK42266.1 - 0.056 13.2 1.6 0.17 11.7 1.6 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger C1_1 PF00130.22 PIK42266.1 - 0.06 13.2 4.8 0.092 12.6 1.2 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 PIK42266.1 - 0.94 9.9 4.9 1.9 8.9 4.9 1.6 1 1 0 1 1 1 0 Ring finger domain SSF PF00474.17 PIK42268.1 - 1e-27 97.1 22.0 1.7e-27 96.4 22.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family FixQ PF05545.11 PIK42269.1 - 0.065 13.2 0.4 0.065 13.2 0.4 3.1 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ LRR_8 PF13855.6 PIK42270.1 - 1.9e-23 82.0 14.2 1.2e-07 31.4 1.0 5.0 3 1 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK42270.1 - 4.3e-14 52.6 6.9 3.4e-07 30.3 0.3 3.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 PIK42270.1 - 2.1e-06 27.2 6.0 3.9e-06 26.4 2.9 3.2 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 PIK42270.1 - 2.2e-06 27.9 29.2 0.042 14.3 0.1 7.0 3 2 7 10 10 10 7 Leucine Rich repeats (2 copies) Ephrin_rec_like PF07699.13 PIK42270.1 - 0.00018 21.2 4.0 0.00018 21.2 4.0 5.0 3 1 2 5 5 5 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK42270.1 - 0.0012 18.7 19.6 0.063 13.3 1.3 4.1 3 0 0 3 3 3 3 Nine Cysteines Domain of family 3 GPCR PRA1 PF03208.19 PIK42270.1 - 0.092 12.4 0.1 0.092 12.4 0.1 2.6 3 0 0 3 3 3 0 PRA1 family protein LRR_9 PF14580.6 PIK42270.1 - 0.11 12.0 3.2 0.2 11.2 0.2 2.3 1 1 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK42270.1 - 0.13 12.4 0.0 0.13 12.4 0.0 6.2 7 0 0 7 7 7 0 Leucine Rich repeat THAP PF05485.12 PIK42271.1 - 1.9e-13 51.1 0.0 3.8e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 THAP domain LRRNT PF01462.18 PIK42273.1 - 2.9e-07 30.0 1.8 6.6e-07 28.8 1.8 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain fn3 PF00041.21 PIK42274.1 - 1.4e-35 121.4 10.9 2.6e-09 37.3 0.2 4.5 4 0 0 4 4 4 4 Fibronectin type III domain EGF_2 PF07974.13 PIK42274.1 - 9.7e-07 29.1 49.9 0.00012 22.3 7.7 4.9 3 2 1 4 4 4 2 EGF-like domain Pur_ac_phosph_N PF16656.5 PIK42274.1 - 1.8e-05 25.2 6.2 1.5 9.5 0.2 4.5 3 1 1 4 4 4 3 Purple acid Phosphatase, N-terminal domain I-set PF07679.16 PIK42274.1 - 0.00014 21.8 0.0 0.00049 20.1 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain hEGF PF12661.7 PIK42274.1 - 0.00016 22.2 6.3 0.00016 22.2 6.3 4.8 4 1 0 4 4 4 1 Human growth factor-like EGF Ig_3 PF13927.6 PIK42274.1 - 0.0079 16.8 0.0 0.053 14.1 0.0 2.5 1 0 0 1 1 1 1 Immunoglobulin domain DSL PF01414.19 PIK42274.1 - 0.91 9.8 48.5 0.63 10.4 13.1 3.8 3 0 0 3 3 3 0 Delta serrate ligand Laminin_EGF PF00053.24 PIK42274.1 - 1 9.5 48.2 8.1 6.7 13.4 5.0 1 1 5 6 6 6 0 Laminin EGF domain Pkinase_Tyr PF07714.17 PIK42275.1 - 2.1e-62 210.8 0.0 2.4e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42275.1 - 6.3e-25 88.0 0.0 9.2e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 PIK42275.1 - 0.017 13.9 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 PIK42275.1 - 0.14 12.1 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 PIK42275.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Fis1_TPR_N PF14852.6 PIK42278.1 - 0.0055 16.3 0.1 0.009 15.7 0.1 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat EGF PF00008.27 PIK42279.1 - 2.8e-06 27.5 3.9 8.5e-06 26.0 3.9 1.9 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK42279.1 - 7.1e-05 23.3 3.9 7.1e-05 23.3 3.9 2.0 2 0 0 2 2 2 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK42279.1 - 0.028 14.8 4.7 0.097 13.1 4.7 1.9 1 1 0 1 1 1 0 EGF-like domain Comm PF15957.5 PIK42280.1 - 0.079 13.3 0.9 0.14 12.6 0.9 1.3 1 0 0 1 1 1 0 Commissureless Nodulin_late PF07127.11 PIK42281.1 - 0.018 15.4 4.6 0.018 15.4 4.6 2.2 2 0 0 2 2 2 0 Late nodulin protein WAP PF00095.21 PIK42281.1 - 9 6.8 13.4 3.3e+02 1.8 13.4 2.3 1 1 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' PIP49_C PF12260.8 PIK42282.1 - 4.2e-10 39.6 0.0 7.5e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Pkinase PF00069.25 PIK42282.1 - 0.0041 16.5 0.0 0.024 14.0 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK42282.1 - 0.0075 15.6 0.2 0.016 14.5 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42283.1 - 8.6e-06 25.3 1.2 1.3e-05 24.8 1.2 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK42283.1 - 9.4e-06 25.1 0.8 1.5e-05 24.4 0.8 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase PIP49_C PF12260.8 PIK42283.1 - 7.1e-05 22.5 0.1 0.00013 21.7 0.0 1.4 1 1 0 1 1 1 1 Protein-kinase domain of FAM69 ubiquitin PF00240.23 PIK42284.1 - 4.3e-10 39.2 2.4 6.9e-10 38.5 0.0 2.4 3 0 0 3 3 3 1 Ubiquitin family BAG PF02179.16 PIK42284.1 - 3.9e-08 33.6 3.3 7.2e-08 32.7 3.3 1.5 1 0 0 1 1 1 1 BAG domain Ubiquitin_2 PF14560.6 PIK42284.1 - 0.00021 21.7 0.6 0.00078 19.8 0.0 2.3 3 1 0 3 3 3 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK42284.1 - 0.0043 17.4 0.0 0.014 15.7 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-like domain Nsp1_C PF05064.13 PIK42284.1 - 0.29 10.9 3.6 0.56 10.0 3.6 1.5 1 0 0 1 1 1 0 Nsp1-like C-terminal region NYD-SP28 PF14772.6 PIK42284.1 - 0.3 11.2 7.0 0.2 11.7 0.8 2.2 2 0 0 2 2 2 0 Sperm tail ABC_tran_CTD PF16326.5 PIK42284.1 - 0.54 10.5 6.7 1.1 9.6 6.7 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain APG6_N PF17675.1 PIK42284.1 - 1.2 9.7 10.3 1.1 9.8 7.2 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region FliT PF05400.13 PIK42284.1 - 3.4 8.5 6.8 1.1 10.2 2.0 2.1 1 1 1 2 2 2 0 Flagellar protein FliT Thioredoxin PF00085.20 PIK42285.1 - 1.4e-05 25.0 0.0 1.6e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Fer4_20 PF14691.6 PIK42286.1 - 3.4e-33 113.8 0.2 6.2e-33 112.9 0.2 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster DHO_dh PF01180.21 PIK42286.1 - 2.8e-17 62.9 0.0 1.4e-16 60.5 0.0 2.0 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Pyr_redox_2 PF07992.14 PIK42286.1 - 9.4e-14 51.3 0.0 2.1e-13 50.2 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Dus PF01207.17 PIK42286.1 - 5.9e-07 28.9 0.4 1e-06 28.1 0.4 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) NAD_binding_8 PF13450.6 PIK42286.1 - 1.6e-06 28.2 0.0 5.3e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK42286.1 - 2.7e-06 26.9 0.0 0.0018 17.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK42286.1 - 0.0002 21.8 0.1 0.12 12.9 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 PIK42286.1 - 0.052 13.6 0.0 9.3 6.3 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 PIK42286.1 - 0.068 12.7 0.1 0.7 9.4 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK42286.1 - 0.13 11.3 0.6 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Fer4_10 PF13237.6 PIK42286.1 - 2.7 8.2 12.2 0.56 10.4 6.8 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 PIK42287.1 - 1.3e-24 86.1 12.8 2.8e-24 85.0 12.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 PIK42287.1 - 1e-07 31.4 14.6 0.00078 19.2 4.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 PIK42287.1 - 2.2e-07 30.6 13.5 0.00077 19.4 2.5 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 PIK42287.1 - 2.9e-06 27.3 21.5 1.7e-05 24.8 11.3 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 PIK42287.1 - 6.2e-06 26.7 23.0 3.2e-05 24.4 12.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 PIK42287.1 - 7e-06 26.5 4.5 0.023 15.2 0.4 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 PIK42287.1 - 1e-05 25.9 4.0 0.0081 16.6 0.1 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 PIK42287.1 - 1.3e-05 25.1 17.8 0.00024 21.0 2.6 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 PIK42287.1 - 5.7e-05 23.2 10.7 0.00014 21.9 10.7 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain DHO_dh PF01180.21 PIK42287.1 - 9.2e-05 21.8 0.1 0.00015 21.1 0.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Fer4_22 PF17179.4 PIK42287.1 - 0.0019 19.0 7.5 0.39 11.6 1.3 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 PIK42287.1 - 0.0034 17.8 17.9 0.038 14.5 2.9 2.8 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 PIK42287.1 - 0.021 15.3 14.1 0.37 11.4 3.1 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 PIK42287.1 - 0.038 14.9 4.0 0.038 14.9 4.0 3.3 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_16 PF13484.6 PIK42287.1 - 0.17 12.9 14.7 0.19 12.7 2.5 2.6 1 1 2 3 3 3 0 4Fe-4S double cluster binding domain Fer4_15 PF13459.6 PIK42287.1 - 3.9 8.3 10.4 13 6.6 0.4 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 PIK42287.1 - 8 6.7 15.5 2.1 8.6 5.3 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain NACHT PF05729.12 PIK42288.1 - 1.6e-16 60.7 0.0 3e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK42288.1 - 0.00038 20.1 0.0 0.00087 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK42288.1 - 0.0034 17.7 0.0 0.016 15.4 0.0 2.2 1 1 1 2 2 2 1 AAA domain DAP3 PF10236.9 PIK42288.1 - 0.018 14.3 0.1 0.73 8.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK42288.1 - 0.072 13.5 0.1 1.4 9.3 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain V-set PF07686.17 PIK42289.1 - 1.5e-09 38.0 0.2 1.1e-05 25.5 0.0 2.9 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42289.1 - 1.7e-08 34.9 0.2 7.4e-05 23.3 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK42289.1 - 2.1e-06 27.8 0.0 0.058 13.6 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain tRNA_synt_1c_R2 PF04557.15 PIK42289.1 - 0.012 16.5 0.2 0.02 15.8 0.2 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF5122 PF17164.4 PIK42289.1 - 0.028 14.7 0.4 1.4 9.3 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Calici_coat_C PF08435.11 PIK42289.1 - 0.07 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal V-set PF07686.17 PIK42291.1 - 1.8e-09 37.7 0.4 7e-05 23.0 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42291.1 - 3.2e-08 34.1 5.3 0.00098 19.7 0.1 4.4 3 2 1 4 4 4 2 Immunoglobulin domain NACHT PF05729.12 PIK42291.1 - 2.7e-05 24.2 0.1 6.4e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 NACHT domain ig PF00047.25 PIK42291.1 - 0.00082 19.5 4.9 0.43 10.8 0.0 4.4 4 2 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK42291.1 - 0.0011 19.0 1.8 2.4 8.3 0.0 3.8 3 2 1 4 4 4 2 Immunoglobulin I-set domain AAA_25 PF13481.6 PIK42291.1 - 0.0037 16.9 0.0 0.0057 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain C2-set_2 PF08205.12 PIK42291.1 - 0.016 15.2 1.5 2.6 8.2 0.2 2.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain AAA_22 PF13401.6 PIK42291.1 - 0.079 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain C2-set_2 PF08205.12 PIK42292.1 - 1.1e-08 35.0 1.8 1.9e-05 24.6 0.5 3.7 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK42292.1 - 0.0014 19.0 2.6 0.18 12.2 0.1 3.2 3 0 0 3 3 3 1 Immunoglobulin C1-set domain DUF2207 PF09972.9 PIK42292.1 - 0.0071 15.2 14.4 0.23 10.2 2.3 3.3 3 1 0 3 3 3 2 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 PIK42292.1 - 0.032 15.1 18.1 1.1 10.2 0.8 5.7 5 2 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain DMT_YdcZ PF04657.13 PIK42292.1 - 0.17 12.1 10.5 0.33 11.2 0.3 2.9 2 1 0 2 2 2 0 Putative inner membrane exporter, YdcZ NMN_transporter PF04973.12 PIK42292.1 - 0.35 10.8 19.7 0.34 10.8 1.4 2.8 3 0 0 3 3 3 0 Nicotinamide mononucleotide transporter AA_permease_2 PF13520.6 PIK42292.1 - 0.43 9.3 35.0 0.3 9.9 8.7 3.2 2 1 0 3 3 3 0 Amino acid permease ig PF00047.25 PIK42292.1 - 1.5 9.0 7.1 4.9 7.4 1.1 4.0 5 0 0 5 5 5 0 Immunoglobulin domain DUF4199 PF13858.6 PIK42292.1 - 9.4 6.6 33.9 2.3 8.6 12.6 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF4199) Peptidase_S8 PF00082.22 PIK42293.1 - 7.5e-22 77.9 14.2 1.6e-21 76.9 14.2 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK42293.1 - 1.9e-08 34.9 0.0 6e-08 33.2 0.0 1.9 1 1 0 1 1 1 1 Peptidase inhibitor I9 NDUFV3 PF15880.5 PIK42294.1 - 3e-13 49.5 0.6 4.7e-13 48.9 0.6 1.3 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial CwfJ_C_1 PF04677.15 PIK42295.1 - 5.2e-35 120.0 0.1 1.3e-34 118.7 0.1 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 PIK42295.1 - 1.2e-17 64.5 0.1 3.4e-17 63.1 0.1 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 tRNA_m1G_MT PF01746.21 PIK42296.1 - 8.7e-16 58.2 0.1 5.5e-09 36.0 0.0 3.0 2 1 1 3 3 3 2 tRNA (Guanine-1)-methyltransferase Hce2 PF14856.6 PIK42296.1 - 0.12 12.7 1.9 0.37 11.1 1.2 1.9 2 0 0 2 2 2 0 Pathogen effector; putative necrosis-inducing factor DUF4407 PF14362.6 PIK42296.1 - 0.48 9.7 3.7 0.72 9.2 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 5_nucleotid PF05761.14 PIK42296.1 - 1.9 7.3 6.0 2.6 6.8 6.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family WSC PF01822.19 PIK42298.1 - 3e-08 33.8 3.8 3e-08 33.8 3.8 2.3 2 0 0 2 2 2 1 WSC domain PKD PF00801.20 PIK42298.1 - 0.0023 17.7 0.5 0.015 15.2 0.0 2.6 2 0 0 2 2 2 1 PKD domain PKD PF00801.20 PIK42299.1 - 4.4e-18 64.9 10.2 4.4e-08 32.8 1.3 5.8 6 0 0 6 6 6 4 PKD domain REJ PF02010.15 PIK42299.1 - 3.7e-15 55.7 0.0 4.2e-11 42.3 0.0 3.2 2 1 1 3 3 3 2 REJ domain P2_Phage_GpR PF06891.11 PIK42299.1 - 0.16 12.1 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 P2 phage tail completion protein R (GpR) PLAT PF01477.23 PIK42300.1 - 3.7e-18 66.2 0.0 8.3e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain GPS PF01825.21 PIK42300.1 - 5.6e-06 26.8 6.2 1.2e-05 25.7 6.2 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD_channel PF08016.12 PIK42301.1 - 6.5e-25 87.7 8.5 2e-24 86.1 0.1 2.6 3 0 0 3 3 3 2 Polycystin cation channel Pepdidase_M14_N PF18027.1 PIK42301.1 - 0.047 14.1 0.2 2 8.8 0.1 2.3 2 0 0 2 2 2 0 Cytosolic carboxypeptidase N-terminal domain DUF3899 PF13038.6 PIK42301.1 - 3.2 8.3 6.6 7.3 7.2 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) Sigma_reg_N PF13800.6 PIK42301.1 - 7.3 6.9 5.7 17 5.8 1.0 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Homeodomain PF00046.29 PIK42302.1 - 1.3e-23 82.6 4.4 2.3e-23 81.8 4.4 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 PIK42302.1 - 0.031 14.1 0.3 0.063 13.1 0.3 1.5 1 0 0 1 1 1 0 OAR domain TPR_19 PF14559.6 PIK42303.1 - 4.8e-08 33.4 4.0 0.068 13.7 0.1 4.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42303.1 - 5.7e-08 32.3 6.1 0.013 15.3 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK42303.1 - 7.1e-08 32.3 0.3 0.011 16.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK42303.1 - 8.8e-07 28.5 0.8 0.022 14.4 0.0 3.9 4 0 0 4 4 4 2 TPR repeat TPR_8 PF13181.6 PIK42303.1 - 2.3e-06 27.4 9.3 0.043 14.0 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK42303.1 - 1.3e-05 24.9 9.1 0.11 12.6 0.2 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK42303.1 - 0.00034 21.2 6.5 1.9 9.5 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK42303.1 - 0.0016 18.4 21.1 0.053 13.7 0.5 5.9 6 1 0 6 6 6 2 Tetratricopeptide repeat DUF3856 PF12968.7 PIK42303.1 - 0.0088 16.1 0.2 4.5 7.3 0.0 2.5 2 0 0 2 2 2 2 Domain of Unknown Function (DUF3856) TPR_16 PF13432.6 PIK42303.1 - 0.02 15.5 5.2 0.3 11.8 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK42303.1 - 0.062 14.0 4.1 2 9.3 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK42303.1 - 0.12 12.7 12.8 6.2 7.2 0.2 5.1 4 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK42303.1 - 0.35 11.1 6.0 39 4.6 0.0 4.4 2 1 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 RCC1 PF00415.18 PIK42304.1 - 3.1e-15 56.5 4.0 1.2e-08 35.4 0.1 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK42304.1 - 2.7e-11 43.0 4.4 1e-06 28.4 0.0 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 PIK42305.1 - 4.7e-27 94.3 6.2 5.1e-11 43.0 0.1 4.4 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK42305.1 - 1.2e-16 60.0 11.5 3.3e-06 26.7 0.1 4.7 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 PIK42305.1 - 1.7e-16 60.4 0.3 9.7e-14 51.6 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain Pox_polyA_pol_C PF12629.7 PIK42305.1 - 0.11 12.3 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain BACK PF07707.15 PIK42305.1 - 0.21 11.7 0.4 2.3 8.4 0.1 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch RCC1 PF00415.18 PIK42306.1 - 1.4e-41 140.8 19.0 3.6e-11 43.5 0.2 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK42306.1 - 3.3e-28 96.9 24.6 7.9e-11 41.5 0.2 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 PIK42306.1 - 7.4e-26 90.6 1.3 3.2e-23 82.1 0.2 2.3 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 PIK42306.1 - 0.24 11.5 0.5 1.5 9.0 0.1 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch Ras PF00071.22 PIK42307.1 - 8.4e-57 191.3 0.0 1e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK42307.1 - 8.3e-36 122.8 0.0 1.1e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK42307.1 - 9.5e-14 51.2 0.0 1.1e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK42307.1 - 1.1e-07 31.5 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK42307.1 - 5.1e-06 26.6 0.0 8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK42307.1 - 9e-06 25.7 0.2 0.035 14.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 PIK42307.1 - 0.00064 19.3 0.0 0.009 15.6 0.0 2.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 PIK42307.1 - 0.0012 18.6 0.0 0.0027 17.5 0.0 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 PIK42307.1 - 0.0017 17.9 0.5 0.028 14.0 0.5 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 PIK42307.1 - 0.0044 16.5 0.0 0.0062 16.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 PIK42307.1 - 0.011 16.1 0.0 0.016 15.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 PIK42307.1 - 0.011 15.5 0.1 2.9 7.6 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 PIK42307.1 - 0.014 15.7 0.4 0.049 13.9 0.1 2.0 1 1 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK42307.1 - 0.015 15.2 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 PIK42307.1 - 0.04 13.9 0.1 0.092 12.7 0.1 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 PIK42307.1 - 0.042 13.6 0.1 0.1 12.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK42307.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DLIC PF05783.11 PIK42307.1 - 0.063 12.1 0.0 0.078 11.8 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_7 PF12775.7 PIK42307.1 - 0.081 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 PIK42307.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 PIK42307.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FSA_C PF10479.9 PIK42308.1 - 1.5e-87 294.4 7.5 8.8e-32 110.1 1.5 3.5 2 1 1 3 3 3 3 Fragile site-associated protein C-terminus Abhydro_lipase PF04083.16 PIK42308.1 - 0.056 13.0 0.1 9.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DUF4878 PF12870.7 PIK42310.1 - 0.037 14.3 1.9 0.076 13.3 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4878) FAM76 PF16046.5 PIK42310.1 - 0.55 9.5 6.4 0.93 8.8 6.4 1.3 1 0 0 1 1 1 0 FAM76 protein Sarcoglycan_1 PF04790.13 PIK42313.1 - 0.029 13.7 0.0 0.037 13.4 0.0 1.1 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein DUF2177 PF09945.9 PIK42315.1 - 0.0025 17.9 0.2 0.0036 17.4 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2177) PMI_typeI PF01238.21 PIK42316.1 - 2.9e-115 385.5 0.0 3.3e-115 385.3 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 PIK42316.1 - 0.015 15.2 0.0 6.8 6.6 0.0 2.7 2 1 1 3 3 3 0 AraC-like ligand binding domain Retrotran_gag_2 PF14223.6 PIK42316.1 - 0.11 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type ZapB PF06005.12 PIK42316.1 - 0.14 12.7 0.2 0.27 11.7 0.2 1.5 1 0 0 1 1 1 0 Cell division protein ZapB C4 PF01413.19 PIK42317.1 - 2.5e-82 272.5 2.0 2.6e-42 143.7 0.1 2.0 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 PIK42317.1 - 4.1e-16 58.5 55.9 1.2e-09 37.8 25.9 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK42318.1 - 4.1e-28 96.9 95.7 1.6e-09 37.3 34.4 4.5 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Ipi1_N PF12333.8 PIK42319.1 - 0.029 15.0 0.8 0.3 11.7 0.2 2.8 1 1 1 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation dsrm PF00035.26 PIK42320.1 - 0.091 13.5 0.0 0.18 12.6 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif cNMP_binding PF00027.29 PIK42321.1 - 2.7e-16 59.4 0.1 3.9e-16 58.9 0.1 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK42322.1 - 0.031 14.2 1.1 0.031 14.2 1.1 2.6 2 0 0 2 2 2 0 Ion channel Sigma70_ECF PF07638.11 PIK42322.1 - 0.048 13.5 0.3 0.075 12.9 0.3 1.2 1 0 0 1 1 1 0 ECF sigma factor Ion_trans PF00520.31 PIK42323.1 - 2.1e-16 59.9 8.3 3.2e-16 59.3 8.3 1.3 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK42323.1 - 2.5e-16 59.5 0.1 4.4e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK42323.1 - 1.8e-05 24.6 3.2 4.4e-05 23.4 3.2 1.6 1 0 0 1 1 1 1 Ion channel Glyco_transf_10 PF00852.19 PIK42324.1 - 9.3e-51 172.0 0.1 1.5e-50 171.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK42324.1 - 2e-11 44.3 0.4 3.7e-11 43.4 0.4 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal MFS_1 PF07690.16 PIK42325.1 - 2.8e-23 82.4 30.2 4.6e-15 55.4 11.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK42325.1 - 2.2e-15 56.5 26.7 4.7e-15 55.4 8.5 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter CUB PF00431.20 PIK42326.1 - 5.2e-43 145.9 0.2 1.3e-28 99.5 0.1 2.0 2 0 0 2 2 2 2 CUB domain Peptidase_S8 PF00082.22 PIK42327.1 - 5.1e-15 55.5 6.3 3.5e-13 49.5 4.9 2.2 2 0 0 2 2 2 2 Subtilase family Inhibitor_I9 PF05922.16 PIK42327.1 - 1.6e-08 35.0 0.1 3.7e-08 33.9 0.1 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I9 cNMP_binding PF00027.29 PIK42328.1 - 1.9e-15 56.7 0.1 3.5e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Rad60-SLD PF11976.8 PIK42330.1 - 9.7e-13 47.8 1.8 4.5e-08 32.8 0.1 3.1 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 PIK42330.1 - 0.0043 16.8 0.1 0.47 10.3 0.0 3.0 3 0 0 3 3 3 1 Ubiquitin family DUF4663 PF15668.5 PIK42330.1 - 0.84 8.6 5.2 1.3 8.0 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) LIN37 PF15306.6 PIK42330.1 - 1.1 9.5 5.8 2.6 8.3 5.8 1.6 1 0 0 1 1 1 0 LIN37 PRIMA1 PF16101.5 PIK42330.1 - 2.2 8.4 5.9 2 8.5 3.1 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 FAM91_N PF14647.6 PIK42331.1 - 5.7e-68 229.5 5.1 6.8e-68 229.2 5.1 1.0 1 0 0 1 1 1 1 FAM91 N-terminus Fibrinogen_C PF00147.18 PIK42332.1 - 1.8e-40 139.1 0.7 2.5e-40 138.7 0.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK42332.1 - 7.5e-05 22.6 2.9 7.5e-05 22.6 2.9 3.6 2 1 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK42332.1 - 0.0025 18.0 12.0 0.0025 18.0 12.0 3.5 3 1 0 3 3 3 1 EGF domain Pyr_redox_2 PF07992.14 PIK42333.1 - 1.3e-24 86.9 1.3 1.6e-24 86.7 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK42333.1 - 7.5e-13 48.9 2.3 1.4e-09 38.4 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK42333.1 - 9e-07 28.4 1.1 0.00073 18.9 0.6 2.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK42333.1 - 1.3e-06 27.8 1.5 5.9e-05 22.4 0.2 2.3 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 PIK42333.1 - 2.1e-05 23.8 0.2 0.015 14.4 0.0 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 PIK42333.1 - 2.7e-05 24.5 2.2 0.11 12.9 0.2 2.4 2 2 0 2 2 2 2 Putative NAD(P)-binding Trp_halogenase PF04820.14 PIK42333.1 - 5.1e-05 22.3 0.8 0.45 9.3 0.1 3.0 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_8 PF13450.6 PIK42333.1 - 0.00011 22.4 1.0 0.26 11.6 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 PIK42333.1 - 0.00018 21.8 2.2 0.1 12.9 0.1 3.0 3 0 0 3 3 3 2 TrkA-N domain AlaDh_PNT_C PF01262.21 PIK42333.1 - 0.00029 20.2 1.1 0.23 10.7 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 PIK42333.1 - 0.00059 19.8 0.2 0.87 9.6 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding GIDA PF01134.22 PIK42333.1 - 0.00086 18.5 3.2 1.1 8.2 0.0 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A Shikimate_DH PF01488.20 PIK42333.1 - 0.0029 17.7 0.7 7.6 6.6 0.2 3.1 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 PIK42333.1 - 0.0039 15.9 1.2 0.14 10.8 0.1 2.8 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 PIK42333.1 - 0.005 16.5 8.4 0.19 11.3 0.5 3.0 2 1 0 3 3 3 2 FAD dependent oxidoreductase Semialdhyde_dh PF01118.24 PIK42333.1 - 0.016 15.7 0.8 2.7 8.5 0.1 2.4 3 0 0 3 3 2 0 Semialdehyde dehydrogenase, NAD binding domain Peptidase_S28 PF05577.12 PIK42333.1 - 0.018 13.8 0.0 1.3 7.8 0.0 2.0 2 0 0 2 2 2 0 Serine carboxypeptidase S28 ThiF PF00899.21 PIK42333.1 - 0.027 13.8 0.8 2.2 7.6 0.0 2.1 2 0 0 2 2 2 0 ThiF family DUF1188 PF06690.11 PIK42333.1 - 0.05 13.2 0.1 0.64 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) DUF3883 PF13020.6 PIK42333.1 - 0.099 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) UDPG_MGDP_dh_N PF03721.14 PIK42333.1 - 0.11 12.1 2.5 2.5 7.6 0.1 2.6 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 PIK42333.1 - 0.11 11.7 1.2 0.91 8.7 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 PIK42333.1 - 0.34 11.2 2.2 0.52 10.6 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 PIK42333.1 - 0.34 10.1 3.9 1.2 8.3 0.2 2.6 2 1 0 2 2 2 0 Thi4 family gag-asp_proteas PF13975.6 PIK42334.1 - 3.7e-09 37.0 0.0 8.1e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK42334.1 - 7.3e-09 36.2 0.0 1.5e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK42334.1 - 0.0006 20.1 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK42334.1 - 0.0034 17.2 0.0 0.0073 16.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK42334.1 - 0.023 14.7 5.9 0.023 14.7 5.9 2.4 3 0 0 3 3 3 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK42335.1 - 6.9e-29 99.8 0.0 1.3e-28 98.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42335.1 - 2e-28 98.7 0.0 6.6e-28 97.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42335.1 - 3e-16 59.6 0.1 4.5e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK42335.1 - 0.00018 21.5 0.0 0.00034 20.7 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Peptidase_A17 PF05380.13 PIK42335.1 - 0.035 14.1 0.0 0.079 13.0 0.0 1.6 2 0 0 2 2 2 0 Pao retrotransposon peptidase Fibrinogen_C PF00147.18 PIK42336.1 - 1.9e-49 168.5 23.4 2.6e-45 154.9 15.4 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42337.1 - 6.7e-28 98.0 0.6 7e-28 97.9 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42338.1 - 1.6e-35 122.9 1.1 1.6e-35 122.9 1.1 1.6 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK42338.1 - 3e-05 23.9 3.9 3e-05 23.9 3.9 2.8 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK42338.1 - 0.0004 20.5 10.2 0.0004 20.5 10.2 3.1 2 2 2 4 4 4 1 EGF domain EGF_MSP1_1 PF12946.7 PIK42338.1 - 4 7.6 10.5 0.84 9.7 4.2 2.7 2 0 0 2 2 2 0 MSP1 EGF domain 1 Pyr_redox_2 PF07992.14 PIK42339.1 - 7.3e-16 58.2 3.8 1.1e-15 57.6 3.8 1.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 PIK42339.1 - 0.00014 21.3 0.9 0.033 13.6 0.0 2.1 2 0 0 2 2 2 2 ThiF family K_oxygenase PF13434.6 PIK42339.1 - 0.00024 20.4 0.9 0.017 14.3 0.1 2.3 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 PIK42339.1 - 0.0003 20.2 0.7 0.17 11.1 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 PIK42339.1 - 0.00086 18.6 2.5 0.091 12.0 0.0 2.1 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK42339.1 - 0.00089 19.8 6.2 0.37 11.4 1.5 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK42339.1 - 0.0016 18.4 1.0 0.81 9.7 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 PIK42339.1 - 0.0018 18.3 1.0 7.6 6.6 0.0 3.0 2 1 1 3 3 3 2 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 PIK42339.1 - 0.013 15.8 2.5 5.4 7.3 0.2 2.9 3 0 0 3 3 3 0 TrkA-N domain FAD_binding_4 PF01565.23 PIK42339.1 - 0.022 14.5 0.9 0.99 9.1 0.1 2.8 3 0 0 3 3 3 0 FAD binding domain GIDA PF01134.22 PIK42339.1 - 0.041 13.0 7.9 0.83 8.7 0.0 3.0 3 0 0 3 3 3 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 PIK42339.1 - 0.049 12.5 1.7 1.8 7.3 0.2 2.6 2 1 1 3 3 3 0 Tryptophan halogenase NAD_binding_7 PF13241.6 PIK42339.1 - 0.067 13.6 0.2 0.067 13.6 0.2 2.4 1 1 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 PIK42339.1 - 0.083 11.9 1.9 6.5 5.7 0.3 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein Ldh_1_N PF00056.23 PIK42339.1 - 0.15 12.2 0.3 5.6 7.1 0.2 2.4 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain MTS_N PF08468.11 PIK42339.1 - 0.16 12.0 0.5 2 8.5 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase small domain N-terminal NAD_binding_8 PF13450.6 PIK42339.1 - 0.34 11.2 5.8 1.9 8.8 0.7 2.5 3 0 0 3 3 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK42339.1 - 0.35 10.4 9.9 5.6 6.4 0.7 2.9 2 1 1 3 3 3 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 PIK42339.1 - 0.74 9.7 3.0 1.7 8.5 0.3 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 PIK42339.1 - 1.1 8.4 3.6 15 4.7 0.4 2.6 2 1 1 3 3 3 0 Thi4 family FAD_binding_3 PF01494.19 PIK42339.1 - 1.9 7.7 4.4 0.71 9.1 0.2 2.0 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 PIK42339.1 - 2.1 8.0 5.2 3 7.5 0.6 2.4 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 PIK42339.1 - 6.6 6.3 6.3 15 5.1 0.2 2.6 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TILa PF12714.7 PIK42340.1 - 2.2e-05 24.3 1.7 2.2e-05 24.3 1.7 3.6 4 0 0 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK42340.1 - 3.8e-05 23.8 4.0 3.8e-05 23.8 4.0 3.4 2 2 1 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK42341.1 - 3.7e-07 30.2 0.1 6.1e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK42341.1 - 4.4e-06 26.5 1.3 4.4e-06 26.5 1.3 2.3 2 0 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK42341.1 - 6e-05 23.1 4.0 6e-05 23.1 4.0 3.2 3 1 1 4 4 4 1 EGF domain SRCR PF00530.18 PIK42345.1 - 8.2e-20 71.2 0.3 1.1e-19 70.8 0.3 1.2 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42345.1 - 4.8e-05 23.8 0.0 7.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK42345.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.5 1 1 0 1 1 1 0 Hepsin, SRCR domain Trypsin PF00089.26 PIK42346.1 - 2e-56 191.3 0.0 2.2e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK42346.1 - 1.4e-06 28.7 0.0 2.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK42346.1 - 0.0033 18.3 0.0 0.0057 17.6 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 PIK42347.1 - 8.7e-30 104.2 0.0 1.4e-29 103.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK42347.1 - 5.7e-09 36.4 0.0 1.4e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ig_2 PF13895.6 PIK42347.1 - 4.6e-06 26.9 0.0 1.1e-05 25.7 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK42347.1 - 5.5e-06 26.4 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42347.1 - 1.8e-05 25.3 0.0 8.8e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Trypsin_2 PF13365.6 PIK42347.1 - 0.00041 21.3 0.1 0.012 16.5 0.0 2.3 1 1 1 2 2 2 1 Trypsin-like peptidase domain ig PF00047.25 PIK42347.1 - 0.008 16.3 0.0 0.037 14.2 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin domain SRCR PF00530.18 PIK42348.1 - 1e-89 295.5 17.9 1.2e-30 105.9 2.5 3.3 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42348.1 - 2.4e-18 66.5 1.3 0.00011 22.7 0.0 3.5 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain I-set PF07679.16 PIK42348.1 - 2e-15 56.6 0.3 5.5e-09 36.0 0.0 3.4 4 0 0 4 4 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42348.1 - 3.7e-13 49.9 0.1 5.6e-07 30.1 0.0 2.9 3 0 0 3 3 2 2 Immunoglobulin domain Hepsin-SRCR PF09272.10 PIK42348.1 - 1.2e-10 41.8 0.3 0.096 13.2 0.0 4.1 4 0 0 4 4 4 3 Hepsin, SRCR domain ig PF00047.25 PIK42348.1 - 1.4e-09 38.0 0.0 0.00026 21.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK42348.1 - 1.2e-08 35.1 0.0 6.3e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK42348.1 - 6.8e-07 29.4 0.3 0.74 10.0 0.0 4.7 4 1 1 5 5 5 2 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK42348.1 - 0.0014 19.0 0.1 0.013 15.9 0.0 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Bac_chlorC PF02043.17 PIK42348.1 - 0.0064 16.5 1.2 3.3 7.8 0.0 3.2 3 0 0 3 3 3 1 Bacteriochlorophyll C binding protein RNA_pol_Rpb2_4 PF04566.13 PIK42348.1 - 0.028 14.7 0.1 11 6.4 0.0 4.0 4 0 0 4 4 4 0 RNA polymerase Rpb2, domain 4 PEP-utilizers PF00391.23 PIK42348.1 - 0.065 13.0 0.3 14 5.5 0.0 3.6 4 0 0 4 4 4 0 PEP-utilising enzyme, mobile domain EutK_C PF16365.5 PIK42348.1 - 0.097 12.7 0.0 66 3.6 0.0 3.3 3 0 0 3 3 3 0 Ethanolamine utilization protein EutK C-terminus AMIN PF11741.8 PIK42348.1 - 0.13 12.4 0.0 20 5.4 0.0 3.2 3 0 0 3 3 3 0 AMIN domain Troponin-I_N PF11636.8 PIK42348.1 - 9.9 6.2 9.2 42 4.2 0.3 3.2 3 0 0 3 3 3 0 Troponin I residues 1-32 BEN PF10523.9 PIK42349.1 - 1.7e-05 25.0 0.0 6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 BEN domain Ribosomal_L1 PF00687.21 PIK42349.1 - 0.0063 16.3 0.1 0.008 15.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family ZapB PF06005.12 PIK42349.1 - 0.019 15.4 3.8 0.034 14.6 3.8 1.4 1 0 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 PIK42349.1 - 0.06 14.0 2.6 0.11 13.1 2.6 1.5 1 1 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 PIK42349.1 - 0.094 12.5 1.2 0.19 11.5 1.2 1.6 1 0 0 1 1 1 0 Septum formation initiator TSC22 PF01166.18 PIK42349.1 - 0.25 11.7 3.9 0.74 10.2 2.7 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF2205 PF10224.9 PIK42349.1 - 0.47 10.5 3.6 3.3 7.8 1.0 2.2 1 1 1 2 2 2 0 Short coiled-coil protein Trypsin PF00089.26 PIK42350.1 - 2.8e-61 207.2 0.0 3.1e-61 207.0 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK42350.1 - 1.2e-07 32.1 0.0 2.2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK42350.1 - 0.0024 18.8 0.0 0.0044 17.9 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain RVT_2 PF07727.14 PIK42351.1 - 4.4e-22 78.9 0.0 5.6e-22 78.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Crr6 PF08847.11 PIK42351.1 - 0.082 12.6 0.0 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 Chlororespiratory reduction 6 Trypsin PF00089.26 PIK42352.1 - 2.7e-62 210.5 0.0 5.2e-62 209.5 0.0 1.5 1 0 0 1 1 1 1 Trypsin I-set PF07679.16 PIK42352.1 - 1.4e-18 66.8 0.0 8.5e-09 35.4 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42352.1 - 3.8e-16 59.5 0.0 1.9e-05 25.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK42352.1 - 2.2e-15 56.7 0.0 0.00011 22.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK42352.1 - 2.3e-09 37.3 0.1 0.074 13.2 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain DUF1986 PF09342.11 PIK42352.1 - 3.7e-08 33.7 0.0 1.1e-07 32.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ig_6 PF18452.1 PIK42352.1 - 2.8e-07 30.0 0.0 0.59 9.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK42352.1 - 0.00092 19.4 0.0 4.7 7.4 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain Trypsin_2 PF13365.6 PIK42352.1 - 0.0078 17.1 0.0 0.07 14.0 0.0 2.6 2 1 0 2 2 2 1 Trypsin-like peptidase domain Izumo-Ig PF16706.5 PIK42352.1 - 0.064 13.3 0.0 3 8.0 0.0 2.9 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain FXa_inhibition PF14670.6 PIK42352.1 - 2.5 8.4 31.1 1.2 9.5 9.2 3.7 3 0 0 3 3 3 0 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK42352.1 - 4.3 8.1 21.9 2.2 9.0 3.9 4.5 4 0 0 4 4 3 0 Human growth factor-like EGF EGF PF00008.27 PIK42352.1 - 6.1 7.3 16.8 8.6 6.8 4.2 3.3 2 0 0 2 2 2 0 EGF-like domain EGF_CA PF07645.15 PIK42352.1 - 6.4 7.1 32.9 2.5 8.4 7.8 5.0 5 1 0 5 5 5 0 Calcium-binding EGF domain SRCR PF00530.18 PIK42353.1 - 2.8e-27 95.1 0.9 3.5e-27 94.8 0.9 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42353.1 - 5.2e-05 23.7 0.2 9.2e-05 22.9 0.0 1.4 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK42353.1 - 0.011 16.3 0.1 0.027 15.0 0.1 1.7 1 1 0 1 1 1 0 Hepsin, SRCR domain SRCR PF00530.18 PIK42354.1 - 0 1194.8 97.3 3.8e-31 107.6 1.3 12.3 12 0 0 12 12 12 12 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK42354.1 - 1.3e-65 218.0 41.3 0.00028 21.4 0.1 12.4 12 0 0 12 12 12 12 Scavenger receptor cysteine-rich domain Trypsin PF00089.26 PIK42354.1 - 7.5e-61 205.8 0.0 3.7e-60 203.5 0.0 2.3 2 0 0 2 2 2 1 Trypsin Hepsin-SRCR PF09272.10 PIK42354.1 - 4.7e-38 130.1 7.6 0.38 11.3 0.0 12.9 12 1 0 12 12 12 12 Hepsin, SRCR domain I-set PF07679.16 PIK42354.1 - 5.4e-24 84.1 0.0 1.6e-08 34.5 0.0 4.1 2 1 1 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42354.1 - 6.8e-21 74.7 0.0 8.1e-07 29.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK42354.1 - 1.2e-14 54.2 0.0 2e-05 24.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK42354.1 - 1.9e-14 53.7 0.0 0.00088 19.6 0.0 3.4 2 1 1 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK42354.1 - 4.5e-12 46.1 0.5 2.2 8.5 0.0 8.6 8 1 0 8 8 8 3 Immunoglobulin V-set domain EutK_C PF16365.5 PIK42354.1 - 2.9e-08 33.6 0.0 51 4.0 0.0 8.2 10 0 0 10 10 9 0 Ethanolamine utilization protein EutK C-terminus Bac_chlorC PF02043.17 PIK42354.1 - 2.7e-06 27.3 25.9 35 4.5 0.0 11.5 12 0 0 12 12 12 0 Bacteriochlorophyll C binding protein DUF1986 PF09342.11 PIK42354.1 - 4.1e-06 27.2 0.7 1.3e-05 25.5 0.0 2.4 2 0 0 2 2 1 1 Domain of unknown function (DUF1986) AMIN PF11741.8 PIK42354.1 - 4.8e-06 26.6 0.0 1.5e+02 2.6 0.0 8.9 11 0 0 11 11 11 0 AMIN domain RNA_pol_Rpb2_4 PF04566.13 PIK42354.1 - 1.3e-05 25.4 14.2 57 4.1 0.0 11.3 12 0 0 12 12 12 0 RNA polymerase Rpb2, domain 4 PSCyt2 PF07583.11 PIK42354.1 - 2e-05 24.6 0.0 62 3.4 0.0 8.7 11 0 0 11 11 11 0 Protein of unknown function (DUF1549) Ig_6 PF18452.1 PIK42354.1 - 0.00012 21.5 0.0 5.5 6.6 0.0 4.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 PIK42354.1 - 0.00058 20.1 0.0 3.5 8.0 0.0 3.7 2 1 1 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK42354.1 - 0.053 13.6 0.1 21 5.2 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain TBCC_N PF16752.5 PIK42355.1 - 0.16 12.5 19.2 0.26 11.7 4.6 3.2 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain Striatin PF08232.12 PIK42355.1 - 0.25 11.9 19.2 4.3 7.9 14.3 2.3 2 0 0 2 2 2 0 Striatin family zf-C4H2 PF10146.9 PIK42355.1 - 0.58 10.4 15.4 0.11 12.7 11.5 1.7 2 0 0 2 2 2 0 Zinc finger-containing protein SlyX PF04102.12 PIK42355.1 - 0.66 10.6 7.3 4.6 7.9 5.0 2.7 2 0 0 2 2 2 0 SlyX TPR_MLP1_2 PF07926.12 PIK42355.1 - 2.3 8.3 19.7 0.062 13.4 7.7 3.0 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 PIK42355.1 - 3.2 7.8 17.1 0.38 10.8 5.8 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding ERM PF00769.19 PIK42355.1 - 4 7.2 28.1 1.1 9.1 21.1 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family SKA1 PF07160.12 PIK42355.1 - 4.4 7.1 17.1 1.1 9.1 11.6 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 HEAT PF02985.22 PIK42356.1 - 2.3e-05 24.2 0.9 0.19 12.1 0.0 3.1 4 0 0 4 4 4 2 HEAT repeat MOR2-PAG1_N PF14222.6 PIK42356.1 - 0.094 11.7 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal HEAT PF02985.22 PIK42357.1 - 0.00033 20.7 0.3 0.0077 16.4 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 PIK42357.1 - 0.038 14.5 1.1 2.3 8.8 0.0 4.0 4 1 1 5 5 5 0 HEAT-like repeat CLASP_N PF12348.8 PIK42357.1 - 0.066 12.8 0.3 15 5.0 0.0 2.5 2 1 0 2 2 2 0 CLASP N terminal Cnd1 PF12717.7 PIK42357.1 - 0.13 12.3 0.1 1.3 9.0 0.0 2.4 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 UPF0183 PF03676.14 PIK42358.1 - 6.5e-146 486.6 1.3 7.4e-146 486.4 1.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) EVC2_like PF12297.8 PIK42359.1 - 1.2e-28 100.0 11.8 1.2e-28 100.0 11.8 3.6 1 1 2 3 3 3 1 Ellis van Creveld protein 2 like protein DUF1493 PF07377.12 PIK42359.1 - 0.052 14.0 0.9 0.052 14.0 0.9 4.6 4 1 0 4 4 4 0 Protein of unknown function (DUF1493) TFIIA_gamma_N PF02268.16 PIK42359.1 - 8 6.6 9.1 30 4.7 0.1 4.7 4 0 0 4 4 4 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF1181 PF06680.11 PIK42361.1 - 0.00021 21.1 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1181) PHO4 PF01384.20 PIK42361.1 - 0.0098 15.0 0.0 0.016 14.2 0.0 1.3 1 1 0 1 1 1 1 Phosphate transporter family LapA_dom PF06305.11 PIK42361.1 - 0.56 10.1 3.4 0.37 10.7 0.7 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF1741 PF08427.10 PIK42363.1 - 4.3e-80 268.7 2.3 4.3e-80 268.7 2.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1741) Kdo_hydroxy PF11004.8 PIK42363.1 - 0.098 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase DUF4653 PF15546.6 PIK42363.1 - 6.5 6.3 5.1 1.8 8.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4653) COPIIcoated_ERV PF07970.12 PIK42364.1 - 1.2e-35 123.4 0.2 2e-35 122.6 0.2 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 PIK42364.1 - 1e-27 96.3 1.0 1.4e-27 95.9 0.0 1.6 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Ferritin PF00210.24 PIK42366.1 - 9.8e-24 83.9 1.8 1.2e-23 83.7 1.8 1.1 1 0 0 1 1 1 1 Ferritin-like domain ADP_ribosyl_GH PF03747.14 PIK42367.1 - 2.5e-62 211.3 0.1 3e-62 211.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Not3 PF04065.15 PIK42367.1 - 0.011 15.1 1.1 0.017 14.5 1.1 1.2 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Mito_carr PF00153.27 PIK42368.1 - 2.6e-32 110.6 2.0 4.6e-21 74.5 0.3 2.1 1 1 1 2 2 2 2 Mitochondrial carrier protein Serine_protease PF18405.1 PIK42368.1 - 0.00099 18.3 0.1 0.0013 18.0 0.1 1.1 1 0 0 1 1 1 1 Gammaproteobacterial serine protease Mito_carr PF00153.27 PIK42369.1 - 3.1e-23 81.5 0.4 2.1e-20 72.4 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Ig_3 PF13927.6 PIK42370.1 - 8.3e-05 23.1 4.5 0.011 16.3 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK42370.1 - 0.00012 22.1 0.5 0.0023 18.0 0.1 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK42370.1 - 0.00037 20.6 0.2 0.0072 16.5 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK42370.1 - 0.00099 19.2 1.8 0.23 11.7 0.2 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK42370.1 - 0.0021 18.3 4.2 0.081 13.3 0.1 3.1 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK42370.1 - 0.0036 17.3 0.0 0.76 9.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Il13Ra_Ig PF18001.1 PIK42370.1 - 0.065 13.3 0.2 0.22 11.6 0.2 1.9 2 0 0 2 2 2 0 Interleukin-13 receptor subunit alpha Ig-like domain DAG1 PF05454.11 PIK42371.1 - 5.7e-06 25.9 0.2 7.4e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.6 PIK42371.1 - 0.00038 20.4 0.3 0.00049 20.0 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 PIK42371.1 - 0.005 17.1 0.5 0.006 16.8 0.5 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator PRIMA1 PF16101.5 PIK42371.1 - 0.011 15.8 0.5 0.017 15.1 0.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 PIK42371.1 - 0.012 16.5 0.2 0.019 15.8 0.2 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Neur_chan_memb PF02932.16 PIK42371.1 - 0.017 15.2 0.1 0.021 14.9 0.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SIT PF15330.6 PIK42371.1 - 0.033 14.6 0.0 0.072 13.5 0.0 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Protocadherin PF08374.11 PIK42371.1 - 0.043 13.8 0.1 0.047 13.7 0.1 1.2 1 0 0 1 1 1 0 Protocadherin GOLD_2 PF13897.6 PIK42371.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking CD34_antigen PF06365.12 PIK42371.1 - 0.32 10.5 2.8 0.62 9.6 2.3 1.6 1 1 1 2 2 2 0 CD34/Podocalyxin family Adeno_E3_CR2 PF02439.15 PIK42371.1 - 0.7 9.7 10.0 1.3 8.8 10.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF5518 PF17647.1 PIK42372.1 - 2e-09 37.6 51.7 0.00056 20.0 14.2 4.3 1 1 1 2 2 2 2 Family of unknown function (DUF5518) Yae1_N PF09811.9 PIK42372.1 - 0.0078 15.9 38.6 1.6 8.5 2.3 4.6 2 1 0 2 2 2 1 Essential protein Yae1, N terminal Thia_YuaJ PF09515.10 PIK42372.1 - 0.028 14.5 36.2 1.3 9.0 1.8 4.9 1 1 1 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) DUF2798 PF11391.8 PIK42372.1 - 0.085 12.9 32.5 3.1 7.9 0.4 3.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2798) DUF2717 PF10911.8 PIK42372.1 - 0.72 9.6 39.6 17 5.2 2.2 8.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2717) ABC2_membrane_3 PF12698.7 PIK42372.1 - 0.83 8.7 20.5 1.1 8.2 20.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF373 PF04123.13 PIK42372.1 - 1.9 7.9 6.1 3.2 7.1 6.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF373) ECF-ribofla_trS PF07155.12 PIK42372.1 - 2.6 8.0 55.2 3.3 7.7 21.4 3.3 1 1 2 3 3 3 0 ECF-type riboflavin transporter, S component SH3_1 PF00018.28 PIK42373.1 - 5.2e-28 96.4 0.0 7e-15 54.4 0.0 2.1 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 PIK42373.1 - 2.1e-24 85.1 0.0 2.1e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 PIK42373.1 - 4.2e-22 77.6 0.0 1.2e-11 44.1 0.0 2.0 2 0 0 2 2 2 2 Variant SH3 domain Mucin_bdg PF03272.13 PIK42373.1 - 0.15 12.1 0.0 1.8 8.6 0.0 2.0 2 0 0 2 2 2 0 Putative mucin or carbohydrate-binding module MaoC_dehydrat_N PF13452.6 PIK42373.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase RhoGEF PF00621.20 PIK42374.1 - 2.4e-18 67.0 0.8 2.4e-18 67.0 0.8 1.5 2 0 0 2 2 2 1 RhoGEF domain DUF4349 PF14257.6 PIK42374.1 - 0.0025 17.3 5.4 0.0037 16.7 4.7 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4349) FapA PF03961.13 PIK42374.1 - 0.0027 16.4 5.2 0.0038 15.9 5.2 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Atg14 PF10186.9 PIK42374.1 - 0.0056 15.8 2.4 0.0097 15.0 2.4 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc24 PF08286.11 PIK42374.1 - 0.015 15.6 5.9 0.015 15.6 5.9 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF1129 PF06570.11 PIK42374.1 - 0.046 13.2 0.1 0.068 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Prefoldin_2 PF01920.20 PIK42374.1 - 0.052 13.5 9.0 0.39 10.7 2.1 3.2 3 1 1 4 4 3 0 Prefoldin subunit CLZ PF16526.5 PIK42374.1 - 0.19 12.1 7.6 0.3 11.5 6.1 2.1 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels V_ATPase_I PF01496.19 PIK42374.1 - 0.22 9.4 4.1 0.26 9.2 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PhaP_Bmeg PF09602.10 PIK42374.1 - 0.25 11.3 8.5 0.6 10.0 8.5 1.6 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1664 PF07889.12 PIK42374.1 - 0.25 11.4 2.0 0.57 10.2 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) GAS PF13851.6 PIK42374.1 - 0.27 10.6 11.7 0.46 9.8 11.3 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Syntaxin-6_N PF09177.11 PIK42374.1 - 0.28 11.8 3.1 0.83 10.2 3.1 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal APG6_N PF17675.1 PIK42374.1 - 0.47 11.0 12.9 1.1 9.8 12.9 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region FlaC_arch PF05377.11 PIK42374.1 - 0.89 10.0 6.2 0.58 10.6 1.7 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TolA_bind_tri PF16331.5 PIK42374.1 - 1.1 9.3 12.9 0.83 9.8 9.5 2.2 1 1 1 2 2 2 0 TolA binding protein trimerisation ABC_tran_CTD PF16326.5 PIK42374.1 - 1.9 8.8 12.2 0.98 9.7 5.4 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain NPV_P10 PF05531.12 PIK42374.1 - 2 9.0 5.5 3.8 8.0 2.6 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein OmpH PF03938.14 PIK42374.1 - 2 8.8 12.4 4 7.8 12.3 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GIT_CC PF16559.5 PIK42374.1 - 2.8 7.9 9.8 1.8 8.5 6.4 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 PF16888.5 PIK42374.1 - 3.8 7.8 12.3 20 5.5 1.5 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) DivIC PF04977.15 PIK42374.1 - 4 7.3 9.8 12 5.8 2.7 2.5 1 1 1 2 2 2 0 Septum formation initiator YabA PF06156.13 PIK42374.1 - 4.8 7.9 9.8 2.6 8.7 6.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 PIK42374.1 - 5.9 7.0 14.5 16 5.5 14.5 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BAR PF03114.18 PIK42375.1 - 2.3e-10 40.5 0.3 2.5e-10 40.4 0.3 1.0 1 0 0 1 1 1 1 BAR domain KapB PF08810.10 PIK42375.1 - 0.03 14.5 0.5 0.28 11.4 0.2 2.0 1 1 1 2 2 2 0 Kinase associated protein B DUF3507 PF12015.8 PIK42375.1 - 0.063 13.0 0.2 0.069 12.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Fib_alpha PF08702.10 PIK42375.1 - 0.11 12.7 0.6 0.11 12.7 0.6 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family SH3_2 PF07653.17 PIK42376.1 - 4.8e-16 58.2 0.0 1.7e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 PIK42376.1 - 3.3e-15 55.7 0.1 1.9e-08 34.0 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK42376.1 - 5.7e-10 38.7 0.2 0.00021 20.8 0.1 2.6 2 0 0 2 2 2 2 SH3 domain BAR PF03114.18 PIK42376.1 - 7e-05 22.6 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 BAR domain HMG14_17 PF01101.18 PIK42376.1 - 0.068 14.1 2.3 0.12 13.3 2.3 1.3 1 0 0 1 1 1 0 HMG14 and HMG17 Ricin_B_lectin PF00652.22 PIK42376.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain GGACT PF06094.12 PIK42377.1 - 1.1e-17 64.7 0.3 1.3e-17 64.5 0.3 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK42377.1 - 0.0093 16.3 0.2 0.016 15.6 0.2 1.4 1 0 0 1 1 1 1 AIG2-like family FlgN PF05130.12 PIK42378.1 - 0.017 15.6 0.1 0.024 15.2 0.1 1.2 1 0 0 1 1 1 0 FlgN protein ig PF00047.25 PIK42379.1 - 4.3e-06 26.8 0.5 0.049 13.8 0.5 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK42379.1 - 3.2e-05 24.4 0.9 1.5 9.5 0.7 3.7 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK42379.1 - 3.6e-05 23.9 2.0 0.53 10.5 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK42379.1 - 0.00044 20.3 0.8 0.0014 18.6 0.8 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK42379.1 - 0.0013 19.1 5.9 2.4 8.5 0.5 4.4 3 2 2 5 5 5 2 Immunoglobulin domain C1-set PF07654.15 PIK42379.1 - 0.007 16.7 4.3 0.01 16.2 0.6 2.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain RT_RNaseH_2 PF17919.1 PIK42380.1 - 8.4e-36 122.0 0.0 1.5e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42380.1 - 2.6e-32 111.2 0.0 5.5e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42380.1 - 2.9e-30 105.4 0.0 5.1e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK42380.1 - 0.067 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) TTC5_OB PF16669.5 PIK42380.1 - 0.11 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain zf-CCHC PF00098.23 PIK42381.1 - 1.7e-07 31.0 4.7 3.4e-07 30.0 4.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK42381.1 - 0.00044 20.1 0.4 0.00088 19.2 0.4 1.5 1 0 0 1 1 1 1 Zinc knuckle Coagulin PF02035.15 PIK42381.1 - 0.11 12.4 0.3 0.17 11.8 0.2 1.5 1 1 0 1 1 1 0 Coagulin zf-CCHC_4 PF14392.6 PIK42381.1 - 0.14 11.9 1.2 0.23 11.2 1.2 1.3 1 0 0 1 1 1 0 Zinc knuckle Shugoshin_C PF07557.11 PIK42381.1 - 0.3 10.9 0.1 0.3 10.9 0.1 2.3 3 0 0 3 3 3 0 Shugoshin C terminus LLC1 PF14945.6 PIK42383.1 - 4.9e-39 133.6 0.1 5.4e-39 133.5 0.1 1.0 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein LLC1 PF14945.6 PIK42384.1 - 2.5e-26 92.6 0.2 2.6e-26 92.5 0.2 1.0 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein CUB PF00431.20 PIK42385.1 - 1.2e-05 25.6 0.0 1.9e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 CUB domain DUF1979 PF09322.10 PIK42386.1 - 3.4e-06 26.9 3.8 5.4 7.0 0.1 5.5 1 1 3 4 4 4 2 Domain of unknown function (DUF1979) CutC PF03932.14 PIK42386.1 - 0.00012 21.7 0.7 0.007 15.9 0.7 2.2 1 1 0 1 1 1 1 CutC family DUF4260 PF14079.6 PIK42386.1 - 0.15 12.0 12.5 11 6.0 1.8 4.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4260) T3SS_ExsE PF18286.1 PIK42386.1 - 0.17 11.9 6.3 30 4.7 0.7 4.0 1 1 4 5 5 5 0 Type III secretion system ExsE AAA_lid_4 PF17864.1 PIK42386.1 - 0.84 9.4 12.8 42 4.0 5.0 4.4 1 1 2 3 3 3 0 RuvB AAA lid domain DUF4129 PF13559.6 PIK42386.1 - 2.4 8.5 5.9 35 4.8 2.9 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4129) ANAPC4_WD40 PF12894.7 PIK42387.1 - 9.3e-13 48.3 1.6 0.0098 16.2 0.2 6.4 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK42387.1 - 1.1e-09 38.7 15.4 0.016 16.0 0.2 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat Frtz PF11768.8 PIK42387.1 - 0.0067 14.8 0.0 0.015 13.6 0.0 1.5 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 PIK42387.1 - 0.035 13.1 0.1 3.3 6.6 0.0 3.6 4 2 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ctf8 PF09696.10 PIK42388.1 - 4.4e-16 59.5 2.0 1.8e-13 51.1 2.0 2.1 1 1 0 1 1 1 1 Ctf8 SBF PF01758.16 PIK42389.1 - 5.2e-29 101.3 14.0 5.2e-29 101.3 14.0 1.6 1 1 0 1 1 1 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK42389.1 - 1.1 7.6 16.7 1.4 7.2 0.4 3.2 1 1 2 3 3 3 0 Membrane transport protein SBF PF01758.16 PIK42390.1 - 1.9e-33 115.8 12.3 3.4e-33 115.0 12.3 1.3 1 0 0 1 1 1 1 Sodium Bile acid symporter family SBF_like PF13593.6 PIK42390.1 - 3.9e-07 29.7 9.4 6.1e-07 29.1 9.4 1.2 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 PIK42391.1 - 2.9e-33 115.2 11.2 2.9e-33 115.2 11.2 2.2 1 1 1 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK42391.1 - 0.023 13.1 7.4 0.063 11.7 2.6 2.5 2 1 0 2 2 2 0 Membrane transport protein VCBS PF13517.6 PIK42392.1 - 3.5e-15 56.3 22.4 3e-08 34.1 0.4 5.5 3 2 3 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK42392.1 - 1.2e-09 38.1 11.9 0.00026 21.0 0.2 5.1 5 0 0 5 5 5 4 FG-GAP repeat Sulfatase PF00884.23 PIK42393.1 - 1.2e-67 228.5 0.0 1.5e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK42393.1 - 2.2e-07 30.8 0.0 1e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK42393.1 - 0.21 10.1 0.0 0.27 9.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Sulfatase_C PF14707.6 PIK42394.1 - 4.3e-26 92.1 0.0 8e-26 91.2 0.0 1.4 1 1 0 1 1 1 1 C-terminal region of aryl-sulfatase Copine PF07002.16 PIK42395.1 - 1.2e-25 90.3 0.0 2.5e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 Copine C2 PF00168.30 PIK42395.1 - 1.2e-05 25.5 0.0 2.4e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK42396.1 - 6.1e-15 55.4 0.5 9e-15 54.8 0.5 1.2 1 0 0 1 1 1 1 C2 domain Kelch_1 PF01344.25 PIK42396.1 - 0.14 11.8 0.7 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 Kelch motif Peptidase_M19 PF01244.21 PIK42397.1 - 1.5e-106 356.2 0.0 1.9e-106 355.9 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) p450 PF00067.22 PIK42398.1 - 1.1e-36 126.7 0.0 1.4e-36 126.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK42399.1 - 6.5e-13 48.2 0.0 6.8e-13 48.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FA_hydroxylase PF04116.13 PIK42401.1 - 5.3e-25 88.3 19.5 5.3e-25 88.3 19.5 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily FA_hydroxylase PF04116.13 PIK42402.1 - 8.8e-26 90.8 19.3 8.8e-26 90.8 19.3 2.1 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily ORF45 PF17620.2 PIK42403.1 - 0.054 13.6 0.1 0.087 12.9 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function Peptidase_C54 PF03416.19 PIK42403.1 - 0.095 12.1 0.4 0.17 11.3 0.4 1.4 1 1 0 1 1 1 0 Peptidase family C54 TrwB_AAD_bind PF10412.9 PIK42403.1 - 0.13 11.2 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ATG16 PF08614.11 PIK42404.1 - 0.00079 19.7 17.5 0.00079 19.7 17.5 1.6 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 PIK42404.1 - 0.0013 18.3 12.1 0.0016 18.0 12.1 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF812 PF05667.11 PIK42404.1 - 0.013 14.5 11.4 0.015 14.2 11.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HK97-gp10_like PF04883.12 PIK42404.1 - 0.013 16.4 1.0 0.036 15.1 0.6 1.9 1 1 1 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component HALZ PF02183.18 PIK42404.1 - 0.016 15.4 4.4 1.5 9.1 0.1 3.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF1390 PF07150.11 PIK42404.1 - 0.017 14.8 1.5 0.022 14.5 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) FUSC PF04632.12 PIK42404.1 - 0.039 12.5 5.4 0.044 12.3 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family IF-2B PF01008.17 PIK42404.1 - 0.04 13.1 3.7 0.049 12.8 3.7 1.1 1 0 0 1 1 1 0 Initiation factor 2 subunit family DivIC PF04977.15 PIK42404.1 - 0.046 13.5 10.2 0.17 11.7 1.4 2.4 1 1 1 2 2 2 0 Septum formation initiator V_ATPase_I PF01496.19 PIK42404.1 - 0.061 11.2 6.8 0.068 11.1 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2031 PF09592.10 PIK42404.1 - 0.066 12.7 7.7 0.087 12.3 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) DUF4763 PF15960.5 PIK42404.1 - 0.074 12.4 8.2 0.065 12.5 2.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Jnk-SapK_ap_N PF09744.9 PIK42404.1 - 0.093 13.0 17.1 0.1 12.8 16.0 1.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 YabA PF06156.13 PIK42404.1 - 0.14 12.8 12.2 0.33 11.6 4.5 2.4 1 1 0 2 2 2 0 Initiation control protein YabA DUF4200 PF13863.6 PIK42404.1 - 0.17 12.3 17.7 0.14 12.5 16.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) ZapB PF06005.12 PIK42404.1 - 0.24 11.8 17.8 0.055 13.9 4.8 2.5 1 1 1 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 PIK42404.1 - 0.36 9.7 11.0 0.48 9.3 11.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF932 PF06067.11 PIK42404.1 - 0.56 9.9 6.4 0.63 9.8 5.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF932) Exonuc_VII_L PF02601.15 PIK42404.1 - 0.78 9.2 8.7 0.99 8.9 8.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Herpes_UL25 PF01499.16 PIK42404.1 - 1.2 7.6 9.8 1.8 7.0 9.6 1.4 1 1 0 1 1 1 0 Herpesvirus UL25 family PRKG1_interact PF15898.5 PIK42404.1 - 1.4 9.9 17.4 0.6 11.0 14.1 1.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Ubiquitin_3 PF14836.6 PIK42404.1 - 1.4 8.9 5.2 3.1 7.9 1.2 2.3 1 1 0 2 2 2 0 Ubiquitin-like domain FlaC_arch PF05377.11 PIK42404.1 - 1.7 9.1 7.7 12 6.4 0.2 2.9 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) JIP_LZII PF16471.5 PIK42404.1 - 1.7 8.9 12.3 0.55 10.4 1.3 3.3 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II LMBR1 PF04791.16 PIK42404.1 - 1.8 7.4 5.9 2 7.2 5.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C4H2 PF10146.9 PIK42404.1 - 1.8 8.8 11.0 4.3 7.6 10.6 1.8 1 1 0 1 1 1 0 Zinc finger-containing protein TMF_TATA_bd PF12325.8 PIK42404.1 - 2 8.7 17.7 0.2 11.9 9.1 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding BST2 PF16716.5 PIK42404.1 - 2.6 8.7 11.4 1.2 9.7 6.9 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Syntaxin_2 PF14523.6 PIK42404.1 - 2.9 8.3 10.4 0.14 12.5 1.6 2.4 1 1 1 2 2 2 0 Syntaxin-like protein Fez1 PF06818.15 PIK42404.1 - 2.9 8.3 15.6 9.9 6.6 15.7 1.7 1 1 0 1 1 1 0 Fez1 TSNAXIP1_N PF15739.5 PIK42404.1 - 3.1 8.2 14.2 0.29 11.5 4.1 2.5 2 1 1 3 3 2 0 Translin-associated factor X-interacting N-terminus APG6_N PF17675.1 PIK42404.1 - 4.3 7.9 19.7 17 5.9 6.5 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region PTB PF08416.13 PIK42405.1 - 9.4e-24 84.0 0.2 1.1e-23 83.9 0.2 1.0 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Ubiquitin_3 PF14836.6 PIK42405.1 - 0.025 14.6 0.1 0.059 13.4 0.1 1.7 2 1 0 2 2 2 0 Ubiquitin-like domain SH3_1 PF00018.28 PIK42406.1 - 2e-13 49.7 0.0 3.2e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK42406.1 - 1.8e-08 34.1 0.0 3e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK42406.1 - 1.9e-07 30.7 0.0 2.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 PIK42406.1 - 4.4e-05 23.5 0.0 6.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 PIK42406.1 - 0.00032 20.9 0.0 0.00069 19.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.6 PIK42406.1 - 0.019 15.4 0.0 0.03 14.7 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain SH3_4 PF06347.13 PIK42406.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain SAM_3 PF18016.1 PIK42407.1 - 3.7e-23 81.1 0.0 5.4e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DinI PF06183.13 PIK42407.1 - 0.025 14.9 0.0 0.067 13.5 0.0 1.7 2 0 0 2 2 2 0 DinI-like family SAM_PNT PF02198.16 PIK42407.1 - 0.048 13.6 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_1 PF00536.30 PIK42407.1 - 0.1 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Anophelin PF10731.9 PIK42408.1 - 0.45 10.4 1.4 2.7 7.9 1.4 2.0 1 1 0 1 1 1 0 Thrombin inhibitor from mosquito DUF3504 PF12012.8 PIK42410.1 - 0.071 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) DUF615 PF04751.14 PIK42410.1 - 0.081 12.9 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Ependymin PF00811.18 PIK42410.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.5 1 1 0 1 1 1 0 Ependymin Hydrolase_6 PF13344.6 PIK42411.1 - 8.5e-21 74.0 0.0 2.9e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase RtcB PF01139.17 PIK42412.1 - 5.5e-36 124.6 0.1 6e-36 124.5 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB RtcB PF01139.17 PIK42413.1 - 3.2e-66 224.2 1.5 3.7e-66 224.0 1.5 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB CorA PF01544.18 PIK42413.1 - 0.096 12.0 0.7 0.13 11.6 0.7 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein RtcB PF01139.17 PIK42414.1 - 5.7e-20 71.9 0.0 6.7e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB GON PF08685.11 PIK42415.1 - 1e-73 247.5 0.2 1.8e-73 246.7 0.2 1.4 1 0 0 1 1 1 1 GON domain TSP_1 PF00090.19 PIK42415.1 - 2.6e-16 59.6 49.0 1.5e-05 25.1 6.6 5.7 5 0 0 5 5 5 4 Thrombospondin type 1 domain DUF4808 PF16066.5 PIK42415.1 - 0.1 13.1 0.0 0.43 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) FOP_dimer PF09398.10 PIK42416.1 - 3.6e-19 68.8 0.1 5.2e-19 68.3 0.1 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 PIK42416.1 - 1.8e-06 26.8 0.1 2.9e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 LisH Pur_DNA_glyco PF02245.16 PIK42417.1 - 3.9e-59 199.0 0.0 5.1e-59 198.6 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) DUF241 PF03087.14 PIK42417.1 - 0.0057 16.5 2.3 0.0088 15.9 2.3 1.2 1 0 0 1 1 1 1 Arabidopsis protein of unknown function zf-C4H2 PF10146.9 PIK42418.1 - 2.4e-60 204.5 11.0 2.8e-60 204.3 11.0 1.0 1 0 0 1 1 1 1 Zinc finger-containing protein DZR PF12773.7 PIK42418.1 - 0.0078 16.2 1.6 0.017 15.1 1.0 1.8 2 0 0 2 2 2 1 Double zinc ribbon zf-C3HC4_3 PF13920.6 PIK42418.1 - 0.013 15.3 2.2 0.022 14.6 2.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_15 PF17032.5 PIK42418.1 - 0.029 15.1 1.2 0.043 14.6 0.4 1.7 2 0 0 2 2 2 0 zinc-ribbon family GST_C_3 PF14497.6 PIK42419.1 - 7.2e-18 64.6 0.0 1.2e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK42419.1 - 1.3e-08 34.9 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK42419.1 - 7.4e-06 26.2 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK42419.1 - 0.00055 19.9 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF2518 PF10726.9 PIK42422.1 - 0.64 9.7 2.5 17 5.0 0.2 2.6 2 0 0 2 2 2 0 Protein of function (DUF2518) YuiB PF14068.6 PIK42423.1 - 6.2 7.5 12.6 4.5 7.9 0.5 3.1 3 0 0 3 3 3 0 Putative membrane protein YuiB PF14068.6 PIK42426.1 - 6 7.5 13.1 2.6 8.7 0.7 3.1 3 0 0 3 3 3 0 Putative membrane protein SCAMP PF04144.13 PIK42428.1 - 0.0075 16.6 4.3 0.0075 16.6 4.3 1.6 2 0 0 2 2 2 1 SCAMP family DUF4728 PF15860.5 PIK42428.1 - 0.099 13.3 6.0 0.057 14.1 3.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) DUF2070 PF09843.9 PIK42431.1 - 0.018 13.4 1.5 0.025 12.9 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4079 PF13301.6 PIK42431.1 - 0.27 11.4 1.9 2.3 8.4 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF1284 PF06935.11 PIK42431.1 - 0.42 11.1 4.9 1 9.8 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) Cluap1 PF10234.9 PIK42433.1 - 2.6e-120 400.8 12.1 4e-120 400.2 12.1 1.3 1 0 0 1 1 1 1 Clusterin-associated protein-1 Lebercilin PF15619.6 PIK42433.1 - 0.00043 20.0 17.2 0.00081 19.1 17.2 1.4 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Glyco_hydro_4C PF11975.8 PIK42433.1 - 0.01 15.9 2.2 0.019 15.0 2.2 1.5 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain NPV_P10 PF05531.12 PIK42433.1 - 0.027 15.0 5.8 0.2 12.1 0.7 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF489 PF04356.12 PIK42433.1 - 0.26 11.3 4.0 0.16 11.9 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Fez1 PF06818.15 PIK42433.1 - 0.34 11.3 20.4 0.38 11.2 19.1 1.8 1 1 0 1 1 1 0 Fez1 GP41 PF00517.17 PIK42433.1 - 0.71 9.7 2.9 18 5.2 0.5 2.6 2 1 0 2 2 2 0 Retroviral envelope protein Exonuc_VII_L PF02601.15 PIK42433.1 - 0.92 9.0 15.6 1.6 8.3 15.6 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Tweety PF04906.13 PIK42433.1 - 1 8.0 7.0 0.23 10.1 0.8 2.1 1 1 1 2 2 2 0 Tweety Bacillus_HBL PF05791.11 PIK42433.1 - 1.1 9.0 10.8 1.9 8.3 3.5 2.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1043 PF06295.12 PIK42433.1 - 1.4 8.9 11.6 1.1 9.3 2.7 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) SLATT_5 PF18160.1 PIK42433.1 - 2.2 7.6 6.8 4.1 6.7 6.8 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 FliD_N PF02465.18 PIK42433.1 - 2.8 8.7 17.3 21 5.9 0.7 3.4 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus FadA PF09403.10 PIK42433.1 - 2.9 8.5 23.1 0.3 11.6 5.5 3.2 1 1 2 3 3 3 0 Adhesion protein FadA Noelin-1 PF12308.8 PIK42433.1 - 3.1 7.8 7.0 1.9 8.5 1.1 2.5 2 0 0 2 2 2 0 Neurogenesis glycoprotein OmpH PF03938.14 PIK42433.1 - 4.8 7.5 23.8 2.6 8.4 10.3 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HAUS-augmin3 PF14932.6 PIK42433.1 - 5.2 6.6 18.6 2 7.9 14.8 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF948 PF06103.11 PIK42433.1 - 6 7.2 5.6 8.7 6.7 0.6 2.6 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 PIK42433.1 - 7.1 5.4 23.6 5.1 5.9 8.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein WD40 PF00400.32 PIK42434.1 - 7.8e-05 23.4 0.7 0.25 12.3 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 PIK42434.1 - 0.0072 15.1 0.1 0.014 14.2 0.1 1.7 1 1 0 1 1 1 1 Nup133 N terminal like UvrD_C PF13361.6 PIK42436.1 - 1.8e-14 53.9 0.0 5.4e-14 52.3 0.1 1.6 1 1 1 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 PIK42436.1 - 8.2e-13 48.9 0.0 2e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 PIK42436.1 - 9.8e-12 45.0 0.2 2e-08 34.1 0.1 2.5 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 PIK42436.1 - 4e-11 43.1 1.0 0.0019 18.0 0.0 3.9 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 PIK42436.1 - 1.8e-10 40.5 1.1 8.2e-09 35.2 0.0 3.5 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain F-box-like PF12937.7 PIK42436.1 - 2.1e-07 30.7 2.8 5.6e-07 29.3 1.6 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK42436.1 - 1.1e-05 25.2 1.0 1.1e-05 25.2 1.0 2.5 3 0 0 3 3 3 1 F-box domain AAA_30 PF13604.6 PIK42436.1 - 0.00022 21.0 0.0 0.0017 18.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK42436.1 - 0.00065 20.0 0.1 0.0038 17.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain DUF4428 PF14471.6 PIK42436.1 - 0.057 13.3 0.1 4.6 7.2 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) PhoH PF02562.16 PIK42436.1 - 0.058 12.8 0.1 6.6 6.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Fringe PF02434.16 PIK42437.1 - 0.086 12.3 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Fringe-like Ig_3 PF13927.6 PIK42438.1 - 1e-05 26.0 0.0 1.7e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK42438.1 - 8.6e-05 22.5 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42438.1 - 0.00058 20.2 0.0 0.00099 19.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK42438.1 - 0.043 14.0 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK42438.1 - 0.1 12.8 0.1 0.22 11.7 0.0 1.7 1 1 1 2 2 2 0 Immunoglobulin V-set domain I-set PF07679.16 PIK42439.1 - 1.6e-34 117.8 0.7 5.2e-13 48.9 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42439.1 - 6.8e-31 106.7 2.6 1.7e-12 47.7 0.0 4.7 4 1 1 5 5 5 3 Immunoglobulin domain ig PF00047.25 PIK42439.1 - 4.1e-22 78.1 0.7 9e-09 35.4 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK42439.1 - 2.1e-18 66.4 0.6 8e-07 29.3 0.0 4.6 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK42439.1 - 1.4e-13 50.9 0.8 6.3e-05 23.1 0.0 5.3 4 2 0 4 4 4 2 Immunoglobulin V-set domain C2-set PF05790.15 PIK42439.1 - 1.3e-06 28.5 0.0 0.36 11.1 0.0 4.5 4 1 1 5 5 5 2 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 PIK42439.1 - 0.00018 21.5 0.5 1.4 9.1 0.1 3.8 4 1 0 4 4 4 2 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK42439.1 - 0.00041 20.7 0.1 6.7 7.2 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK42439.1 - 0.0011 19.0 0.0 0.46 10.6 0.0 3.6 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK42439.1 - 0.0015 18.0 0.0 0.64 9.6 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK42439.1 - 0.026 14.6 0.1 3.8 7.6 0.0 3.8 4 1 0 4 4 4 0 C17orf99 Ig domain Plk4_PB1 PF18190.1 PIK42439.1 - 0.19 11.9 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 1 fn3 PF00041.21 PIK42440.1 - 2.1e-29 101.7 6.5 7.3e-12 45.5 0.0 5.3 5 0 0 5 5 5 4 Fibronectin type III domain Bravo_FIGEY PF13882.6 PIK42440.1 - 3.4e-16 60.4 10.2 9.2e-16 59.0 10.2 1.8 1 0 0 1 1 1 1 Bravo-like intracellular region DAG1 PF05454.11 PIK42440.1 - 0.037 13.4 0.0 0.39 10.1 0.0 2.2 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SCIMP PF15050.6 PIK42440.1 - 0.06 13.8 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 SCIMP protein LRR19-TM PF15176.6 PIK42440.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain SIT PF15330.6 PIK42440.1 - 0.086 13.3 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT fn3_4 PF16794.5 PIK42440.1 - 0.09 12.7 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 Fibronectin-III type domain Baculo_11_kDa PF06143.11 PIK42440.1 - 0.1 12.2 0.2 0.2 11.3 0.2 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family ATP-synt_8 PF00895.20 PIK42440.1 - 0.2 12.2 0.1 0.57 10.7 0.1 1.8 1 0 0 1 1 1 0 ATP synthase protein 8 Big_4 PF07532.11 PIK42440.1 - 2.4 8.0 8.7 3.5 7.5 0.1 4.3 4 1 1 5 5 5 0 Bacterial Ig-like domain (group 4) RVT_1 PF00078.27 PIK42441.1 - 1.7e-14 53.9 0.0 3.5e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MukB PF04310.12 PIK42441.1 - 0.00071 19.4 0.0 0.37 10.6 0.0 2.3 2 0 0 2 2 2 2 MukB N-terminal gag-asp_proteas PF13975.6 PIK42441.1 - 0.0018 18.8 0.0 0.0043 17.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK42441.1 - 0.031 14.4 1.4 0.031 14.4 1.4 2.6 2 0 0 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 PIK42441.1 - 0.048 14.3 0.0 0.098 13.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 PIK42441.1 - 0.17 12.2 0.0 0.48 10.8 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease Integrase_H2C2 PF17921.1 PIK42442.1 - 9.2e-18 64.1 1.3 1.2e-17 63.7 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK42442.1 - 1.3e-17 64.0 0.1 2.2e-17 63.2 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK42442.1 - 5.9e-12 45.5 0.0 1.3e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK42442.1 - 0.0028 17.8 0.0 0.0054 16.9 0.0 1.4 1 0 0 1 1 1 1 H2C2 zinc finger RVT_3 PF13456.6 PIK42442.1 - 0.12 12.2 0.1 0.38 10.6 0.0 1.8 3 0 0 3 3 3 0 Reverse transcriptase-like Rpp20 PF12328.8 PIK42442.1 - 0.15 12.0 0.3 0.39 10.7 0.0 1.8 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P RecR PF02132.15 PIK42442.1 - 0.16 11.6 1.1 0.41 10.2 0.3 2.1 2 0 0 2 2 2 0 RecR protein COesterase PF00135.28 PIK42443.1 - 5.4e-59 200.4 0.0 6.1e-59 200.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family I-set PF07679.16 PIK42445.1 - 2.4e-17 62.8 0.1 9.5e-13 48.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK42445.1 - 9.1e-16 58.2 1.4 1.6e-09 38.3 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK42445.1 - 1.7e-10 40.9 0.4 3.2e-05 24.0 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK42445.1 - 1.7e-10 41.1 0.3 3.4e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK42445.1 - 1.7e-05 24.8 0.4 0.0003 20.8 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK42445.1 - 0.0015 18.7 2.6 1.8 8.8 0.1 3.7 2 2 2 4 4 4 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK42445.1 - 0.0054 17.1 0.2 0.31 11.5 0.0 2.5 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 PIK42445.1 - 0.05 14.0 1.5 0.39 11.1 0.1 2.9 3 1 0 3 3 3 0 Immunoglobulin C1-set domain DUF3465 PF11948.8 PIK42445.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) PKD_3 PF16820.5 PIK42445.1 - 0.13 12.1 0.1 0.53 10.1 0.0 2.1 3 0 0 3 3 3 0 PKD-like domain Dynein_light PF01221.18 PIK42445.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Dynein light chain type 1 I-set PF07679.16 PIK42446.1 - 3.1e-19 68.8 0.0 1.2e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42446.1 - 5e-18 65.2 0.1 2.5e-10 40.5 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK42446.1 - 5.1e-18 65.5 0.0 7.8e-10 39.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK42446.1 - 1.5e-13 50.7 0.2 4e-07 30.1 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK42446.1 - 1.6e-10 41.1 0.7 6.8e-05 23.0 0.1 3.1 2 1 1 3 3 3 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK42446.1 - 2.3e-05 24.3 0.1 0.022 14.8 0.1 2.6 2 1 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK42446.1 - 0.00011 22.4 0.1 0.0034 17.6 0.1 2.4 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK42446.1 - 0.00013 21.5 0.0 0.13 11.9 0.0 2.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 PIK42446.1 - 0.0012 19.2 0.0 0.39 11.2 0.0 2.2 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ank_4 PF13637.6 PIK42447.1 - 6.2e-45 151.0 14.7 1e-11 45.1 0.0 4.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK42447.1 - 1e-39 135.0 10.8 6.3e-17 61.9 0.1 3.8 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 PIK42447.1 - 5.5e-33 112.0 15.2 1.7e-07 31.4 0.1 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 PIK42447.1 - 3.3e-27 94.2 5.3 1.6e-07 31.5 0.2 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK42447.1 - 2.5e-25 85.8 6.4 0.001 19.4 0.1 6.5 7 0 0 7 7 7 6 Ankyrin repeat MRP-S32 PF10210.9 PIK42448.1 - 4.6e-21 75.2 0.7 7.3e-21 74.5 0.7 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 XAP5 PF04921.14 PIK42449.1 - 2.8e-89 299.2 16.8 2.8e-89 299.2 16.8 1.8 1 1 1 2 2 2 1 XAP5, circadian clock regulator RhoGEF PF00621.20 PIK42450.1 - 8.8e-33 114.1 0.7 2.4e-32 112.7 0.1 2.0 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 PIK42450.1 - 2.6e-19 69.7 2.9 3e-09 37.3 0.0 3.0 2 1 0 2 2 2 2 PH domain FYVE PF01363.21 PIK42450.1 - 4.5e-19 68.4 8.9 8e-19 67.6 8.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH_11 PF15413.6 PIK42450.1 - 2.9e-06 27.7 12.9 0.00046 20.6 3.5 4.1 3 1 0 4 4 4 2 Pleckstrin homology domain PH_3 PF14593.6 PIK42450.1 - 7.2e-05 22.8 0.8 0.0053 16.8 0.0 2.8 2 1 0 2 2 2 1 PH domain FYVE_2 PF02318.16 PIK42450.1 - 0.00022 21.4 4.9 0.00049 20.3 4.9 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PH_8 PF15409.6 PIK42450.1 - 0.0004 20.6 0.4 0.17 12.2 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 PIK42450.1 - 0.00068 19.5 0.4 0.00068 19.5 0.4 3.8 3 2 0 4 4 4 1 Pleckstrin homology domain PH_6 PF15406.6 PIK42450.1 - 0.007 16.6 0.1 0.25 11.6 0.0 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 PIK42450.1 - 0.025 14.9 4.2 0.64 10.4 0.3 3.2 2 1 1 3 3 3 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 PIK42450.1 - 0.038 14.0 0.1 0.096 12.7 0.1 1.6 1 0 0 1 1 1 0 PH domain SpoVT_C PF15714.5 PIK42450.1 - 0.042 13.9 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor RNR_Alpha PF17975.1 PIK42450.1 - 0.088 13.3 0.2 0.28 11.7 0.2 1.8 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain Prok-RING_2 PF14445.6 PIK42450.1 - 0.13 12.5 3.5 0.29 11.3 3.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_2 PF13639.6 PIK42450.1 - 1.2 9.6 10.1 2.2 8.7 10.1 1.4 1 0 0 1 1 1 0 Ring finger domain DZR PF12773.7 PIK42450.1 - 1.7 8.7 7.3 16 5.6 0.4 2.4 1 1 1 2 2 2 0 Double zinc ribbon Aldedh PF00171.22 PIK42451.1 - 5.1e-163 542.9 0.2 5.7e-163 542.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Mod_r PF07200.13 PIK42452.1 - 0.011 15.8 1.2 0.019 15.0 1.2 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein YgaB PF14182.6 PIK42452.1 - 0.12 12.8 3.4 0.31 11.5 3.4 1.6 1 0 0 1 1 1 0 YgaB-like protein SLH PF00395.20 PIK42453.1 - 0.042 13.8 0.0 0.28 11.2 0.0 2.3 3 0 0 3 3 3 0 S-layer homology domain RXT2_N PF08595.11 PIK42453.1 - 0.043 13.8 7.6 0.12 12.4 7.6 1.8 1 1 0 1 1 1 0 RXT2-like, N-terminal DUF5614 PF18474.1 PIK42453.1 - 0.37 10.1 3.4 0.52 9.6 1.8 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5614) DUF1840 PF08895.11 PIK42453.1 - 2.2 8.7 10.6 8 6.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) NOA36 PF06524.12 PIK42453.1 - 3.8 6.8 13.1 5.7 6.2 13.1 1.3 1 0 0 1 1 1 0 NOA36 protein RNase_H2_suC PF08615.11 PIK42453.1 - 8.1 6.6 8.3 39 4.4 8.3 2.2 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DNA_pol_phi PF04931.13 PIK42453.1 - 9.1 4.2 17.8 0.9 7.6 12.7 1.9 2 1 0 2 2 2 0 DNA polymerase phi KDZ PF18758.1 PIK42454.1 - 7.9e-40 136.8 0.2 7.9e-40 136.8 0.2 1.6 2 0 0 2 2 2 1 Kyakuja-Dileera-Zisupton transposase CxC1 PF18802.1 PIK42454.1 - 5.2e-07 29.8 2.7 6.6e-07 29.4 0.2 2.3 1 1 1 2 2 2 1 CxC1 like cysteine cluster associated with KDZ transposases CxC2 PF18803.1 PIK42454.1 - 1.7e-06 28.1 0.2 4.9e-06 26.6 0.2 1.8 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK42454.1 - 0.001 18.9 1.6 0.0025 17.7 1.6 1.6 1 0 0 1 1 1 1 CxC3 like cysteine cluster associated with KDZ transposases OTT_1508_deam PF14441.6 PIK42454.1 - 0.017 15.1 0.2 0.051 13.6 0.2 1.8 1 0 0 1 1 1 0 OTT_1508-like deaminase Ac81 PF05820.11 PIK42454.1 - 0.33 10.5 2.3 2.8 7.5 0.1 2.2 2 0 0 2 2 2 0 Baculoviridae AC81 Glyco_transf_10 PF00852.19 PIK42455.1 - 5.5e-33 114.2 0.2 7.9e-33 113.6 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK42456.1 - 6.7e-12 45.8 0.1 1.1e-11 45.2 0.1 1.3 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK42456.1 - 4.8e-06 26.4 0.0 7.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 PIK42457.1 - 8.9e-44 149.3 0.8 1.1e-43 149.0 0.8 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term PIF1 PF05970.14 PIK42458.1 - 0.002 17.4 0.6 0.0041 16.3 0.1 1.7 2 0 0 2 2 2 1 PIF1-like helicase Herpes_Helicase PF02689.14 PIK42458.1 - 0.016 13.2 0.0 0.031 12.2 0.0 1.4 1 1 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 PIK42458.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Tnp_P_element PF12017.8 PIK42459.1 - 7.3e-06 25.6 0.0 1.1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Transposase protein BHD_1 PF10403.9 PIK42459.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 PIF1 PF05970.14 PIK42460.1 - 5.1e-16 58.8 0.4 1.3e-15 57.4 0.1 1.7 1 1 1 2 2 2 1 PIF1-like helicase AAA_19 PF13245.6 PIK42460.1 - 0.025 14.9 0.0 0.046 14.0 0.0 1.5 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 PIK42460.1 - 0.23 11.2 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Glyco_transf_10 PF00852.19 PIK42461.1 - 3.5e-35 121.3 0.1 3.8e-35 121.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term 7tm_1 PF00001.21 PIK42463.1 - 6.4e-13 48.6 5.0 7.5e-13 48.4 5.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK42463.1 - 2.4e-06 27.5 5.8 3e-06 27.2 5.8 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK42463.1 - 0.00033 20.1 6.4 0.00043 19.8 6.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK42463.1 - 0.0019 17.9 8.8 0.0025 17.5 8.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 PIK42463.1 - 0.0029 17.6 4.1 0.0045 17.0 4.1 1.4 1 0 0 1 1 1 1 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srv PF10323.9 PIK42463.1 - 0.034 13.5 8.4 0.15 11.4 5.8 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.9 PIK42463.1 - 0.092 12.2 10.4 0.13 11.8 10.4 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc TMEM72 PF16054.5 PIK42463.1 - 6.4 6.4 8.4 7 6.3 6.1 2.4 1 1 1 2 2 2 0 Transmembrane protein family 72 Myb_DNA-binding PF00249.31 PIK42464.1 - 1e-06 28.8 0.6 4.2e-06 26.9 0.3 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK42464.1 - 0.0087 16.3 1.4 0.025 14.8 0.0 2.3 2 1 1 3 3 3 1 Myb-like DNA-binding domain Macro_2 PF14519.6 PIK42464.1 - 0.02 14.2 1.4 0.034 13.5 1.2 1.3 1 1 0 1 1 1 0 Macro-like domain SANT_DAMP1_like PF16282.5 PIK42464.1 - 0.05 13.8 0.4 0.12 12.6 0.1 1.9 2 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 DUF3870 PF12986.7 PIK42464.1 - 0.067 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) AAA PF00004.29 PIK42465.1 - 2.7e-38 131.4 0.2 6.5e-38 130.1 0.1 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 PIK42465.1 - 6.6e-11 41.8 1.1 1.1e-09 37.9 0.2 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 PIK42465.1 - 1.8e-06 28.2 0.0 4.2e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK42465.1 - 5.6e-06 26.7 0.4 0.00057 20.2 0.2 2.6 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 PIK42465.1 - 0.00014 21.9 0.3 0.00055 19.9 0.1 2.2 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 PIK42465.1 - 0.0013 18.1 0.1 0.0024 17.3 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 PIK42465.1 - 0.0019 17.4 0.0 0.0035 16.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase PF06745.13 PIK42465.1 - 0.0026 17.1 0.1 0.006 15.9 0.1 1.6 1 0 0 1 1 1 1 KaiC RuvB_N PF05496.12 PIK42465.1 - 0.0029 17.4 0.0 0.0079 16.0 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 PIK42465.1 - 0.0054 16.5 0.0 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 PIK42465.1 - 0.0061 17.0 0.0 0.02 15.3 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 PIK42465.1 - 0.0092 16.5 0.0 0.021 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK42465.1 - 0.012 15.3 0.0 0.031 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK42465.1 - 0.013 15.1 0.0 0.03 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 PIK42465.1 - 0.016 15.7 1.2 0.03 14.8 0.1 1.9 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 PIK42465.1 - 0.017 15.5 0.0 0.054 13.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 PIK42465.1 - 0.026 14.7 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK42465.1 - 0.028 14.1 0.0 0.07 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 PIK42465.1 - 0.037 13.9 0.0 0.093 12.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Lipocalin_2 PF08212.12 PIK42465.1 - 0.043 13.7 0.4 0.18 11.7 0.4 1.8 2 0 0 2 2 2 0 Lipocalin-like domain TsaE PF02367.17 PIK42465.1 - 0.052 13.5 0.0 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 PIK42465.1 - 0.069 13.5 0.4 0.31 11.4 0.1 2.0 1 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 PIK42465.1 - 0.075 12.8 1.9 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 PIK42465.1 - 0.14 12.4 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Exo_endo_phos PF03372.23 PIK42466.1 - 1.2e-05 25.0 0.0 1.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK42466.1 - 0.0007 19.4 0.0 0.0019 18.1 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HCO3_cotransp PF00955.21 PIK42467.1 - 5e-185 616.1 3.4 6.3e-185 615.8 3.4 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 PIK42467.1 - 9.1e-64 215.9 0.0 1.8e-63 214.8 0.0 1.5 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Merozoite_SPAM PF07133.11 PIK42467.1 - 0.27 11.2 11.8 0.63 10.0 11.8 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) TSP_1 PF00090.19 PIK42468.1 - 1.8e-10 40.9 34.0 0.0014 18.8 6.0 3.8 3 2 0 3 3 3 3 Thrombospondin type 1 domain Tau95_N PF17682.1 PIK42469.1 - 2.2e-32 111.9 0.0 4.1e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 Tau95 Triple barrel domain Tau95 PF09734.9 PIK42469.1 - 0.0029 18.4 0.1 0.007 17.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain ATG27 PF09451.10 PIK42470.1 - 2.7e-05 24.2 0.0 0.05 13.5 0.1 2.5 2 0 0 2 2 2 2 Autophagy-related protein 27 LYRIC PF15686.5 PIK42470.1 - 4.4e-05 23.2 8.6 0.0047 16.5 0.9 2.7 2 1 1 3 3 3 2 Lysine-rich CEACAM1 co-isolated protein family TMEM52 PF14979.6 PIK42470.1 - 0.00017 21.5 0.0 0.098 12.6 0.0 2.6 2 0 0 2 2 2 2 Transmembrane 52 TMEM154 PF15102.6 PIK42470.1 - 0.021 14.7 0.0 6.3 6.7 0.0 2.4 2 0 0 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 PIK42470.1 - 0.065 14.1 0.0 21 6.1 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Phage_holin_3_6 PF07332.11 PIK42470.1 - 0.46 10.5 1.9 23 5.1 0.1 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Fibrinogen_C PF00147.18 PIK42471.1 - 8.6e-34 117.3 9.9 9.6e-34 117.1 9.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RhoGAP PF00620.27 PIK42472.1 - 3e-41 140.8 0.0 1.2e-40 138.8 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain BAR PF03114.18 PIK42472.1 - 4.1e-30 105.2 9.6 6.3e-30 104.6 9.6 1.2 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 PIK42472.1 - 0.00017 20.8 2.4 0.00026 20.3 2.4 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Atg14 PF10186.9 PIK42472.1 - 0.015 14.4 1.6 0.031 13.4 1.6 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BPL_N PF09825.9 PIK42472.1 - 0.087 11.9 1.6 3.8 6.5 1.1 2.1 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal ATPase PF06745.13 PIK42472.1 - 0.13 11.6 1.0 0.32 10.3 1.0 1.6 1 0 0 1 1 1 0 KaiC ADIP PF11559.8 PIK42472.1 - 0.36 10.9 6.1 1.9 8.5 4.0 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4398 PF14346.6 PIK42472.1 - 0.54 10.9 3.3 1 10.1 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) BAR_3 PF16746.5 PIK42472.1 - 0.6 9.8 10.6 0.14 11.8 7.5 1.5 2 0 0 2 2 2 0 BAR domain of APPL family DUF2203 PF09969.9 PIK42472.1 - 2.2 9.0 4.1 32 5.3 1.4 3.1 3 1 2 5 5 5 0 Uncharacterized conserved protein (DUF2203) OST-HTH PF12872.7 PIK42475.1 - 1.5e-36 124.0 0.2 3.3e-09 36.4 0.0 8.2 8 0 0 8 8 8 5 OST-HTH/LOTUS domain NYN PF01936.18 PIK42475.1 - 6.2e-19 68.9 0.1 1.4e-18 67.8 0.1 1.6 1 0 0 1 1 1 1 NYN domain Limkain-b1 PF11608.8 PIK42475.1 - 0.0014 18.7 0.1 0.091 12.8 0.0 3.5 3 1 1 4 4 4 1 Limkain b1 RRM_1 PF00076.22 PIK42475.1 - 0.0096 15.7 0.0 0.041 13.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hid1 PF12722.7 PIK42476.1 - 0.03 12.5 1.4 0.036 12.2 1.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein tRNA_int_end_N2 PF12928.7 PIK42477.1 - 5.5e-10 39.3 0.2 1.7e-09 37.7 0.1 1.9 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term Zn-ribbon_8 PF09723.10 PIK42479.1 - 0.56 10.4 0.1 0.56 10.4 0.1 2.7 3 1 0 3 3 3 0 Zinc ribbon domain DUF4722 PF15849.5 PIK42480.1 - 0.0098 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4722) DUF1068 PF06364.12 PIK42481.1 - 0.26 11.1 2.5 5.9 6.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1068) RVT_1 PF00078.27 PIK42482.1 - 2.9e-20 72.7 0.0 3.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_19 PF13245.6 PIK42483.1 - 1.1e-05 25.9 0.8 2.5e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain PIF1 PF05970.14 PIK42483.1 - 0.00046 19.5 0.4 0.00046 19.5 0.4 1.9 1 1 1 2 2 2 1 PIF1-like helicase AAA_30 PF13604.6 PIK42483.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 PIK42483.1 - 0.017 14.6 5.0 0.029 13.9 0.2 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain AAT PF03417.16 PIK42484.1 - 0.051 13.3 0.2 0.068 12.9 0.2 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Fil_haemagg PF05594.14 PIK42486.1 - 0.11 13.1 4.4 2.9 8.5 0.1 2.6 2 0 0 2 2 2 0 Haemagluttinin repeat GIDA_assoc PF13932.6 PIK42486.1 - 0.67 10.1 12.0 2.2 8.4 1.2 2.9 3 0 0 3 3 3 0 GidA associated domain DEAD PF00270.29 PIK42487.1 - 3.4e-35 121.4 0.2 7.5e-35 120.3 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK42487.1 - 2.6e-17 63.2 0.1 1.6e-16 60.6 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK42487.1 - 9.1e-07 29.0 0.0 2.3e-06 27.7 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 PIK42487.1 - 0.00049 19.5 0.0 0.00094 18.6 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 PIK42487.1 - 0.0007 19.4 0.1 0.0017 18.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK42487.1 - 0.0016 18.8 0.1 0.0062 16.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 PIK42487.1 - 0.0089 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Helicase Mito_fiss_reg PF05308.11 PIK42487.1 - 0.012 15.7 4.0 0.02 15.0 4.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Flavi_DEAD PF07652.14 PIK42487.1 - 0.016 15.2 0.0 0.14 12.1 0.0 2.3 1 1 0 1 1 1 0 Flavivirus DEAD domain UvrD-helicase PF00580.21 PIK42487.1 - 0.052 13.1 0.0 0.066 12.7 0.0 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Thioredoxin_3 PF13192.6 PIK42487.1 - 0.065 13.3 0.1 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin domain AAA_22 PF13401.6 PIK42487.1 - 0.14 12.4 0.1 0.61 10.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain CAP_N PF01213.19 PIK42487.1 - 1.7 8.1 9.0 3 7.2 9.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 PIK42487.1 - 2.5 8.2 12.8 5.2 7.1 12.8 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-H2C2_2 PF13465.6 PIK42488.1 - 6.2e-70 228.7 104.0 3.9e-10 39.7 2.1 14.3 15 0 0 15 15 15 10 Zinc-finger double domain zf-C2H2 PF00096.26 PIK42488.1 - 2.1e-42 141.3 87.9 2.2e-05 24.6 1.5 12.0 12 1 0 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42488.1 - 3.6e-30 102.0 80.2 0.001 19.7 0.9 11.1 12 0 0 12 12 11 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK42488.1 - 1.2e-12 47.7 55.2 0.027 14.8 0.5 10.5 10 0 0 10 10 9 7 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK42488.1 - 8.4e-08 32.0 50.8 0.54 10.2 1.3 9.4 8 1 1 9 9 9 7 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK42488.1 - 1.2e-07 31.3 30.1 0.024 14.4 0.1 8.7 8 0 0 8 8 8 2 zinc-finger C2H2-type zf-met PF12874.7 PIK42488.1 - 3.6e-06 27.2 61.0 0.0028 18.0 2.0 10.5 11 0 0 11 11 11 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK42488.1 - 0.00026 20.9 66.2 0.5 10.4 0.2 10.0 9 1 0 9 9 9 6 C2H2-type zinc finger GAGA PF09237.11 PIK42488.1 - 0.0009 19.0 8.7 5.3 6.9 0.0 5.5 1 1 5 7 7 7 1 GAGA factor C1_4 PF07975.12 PIK42488.1 - 0.0054 16.9 42.3 0.35 11.2 0.1 7.2 1 1 6 8 8 8 4 TFIIH C1-like domain zf-Di19 PF05605.12 PIK42488.1 - 0.061 13.6 48.3 0.35 11.2 2.8 6.0 1 1 7 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.8 PIK42488.1 - 1.6 9.1 36.6 0.47 10.8 1.3 5.3 2 1 5 8 8 8 0 zinc-finger-containing domain zf-C2HE PF16278.5 PIK42488.1 - 6.7 7.2 59.6 8.1 7.0 1.0 9.2 1 1 6 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger BolA PF01722.18 PIK42488.1 - 6.8 7.0 9.6 6.7 7.1 0.1 4.0 4 0 0 4 4 4 0 BolA-like protein zf-met PF12874.7 PIK42489.1 - 0.00016 21.9 0.2 0.00028 21.2 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 PIK42489.1 - 0.00055 20.6 0.9 0.00095 19.8 0.9 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK42489.1 - 0.0021 18.4 1.2 0.0034 17.7 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 PIK42489.1 - 0.01 15.5 0.6 0.018 14.8 0.6 1.3 1 0 0 1 1 1 0 zinc-finger C2H2-type DNA_pol_A_exo1 PF01612.20 PIK42490.1 - 2.6e-05 24.0 0.0 4.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease DDT PF02791.17 PIK42490.1 - 0.092 13.1 0.1 2.3 8.6 0.0 2.4 1 1 1 2 2 2 0 DDT domain Collagen PF01391.18 PIK42491.1 - 5.9e-31 106.0 106.8 1.6e-07 31.0 20.6 6.4 3 1 3 6 6 6 6 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK42492.1 - 3.4e-42 142.0 162.0 1.3e-08 34.5 28.0 8.6 2 2 3 5 5 5 4 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK42494.1 - 7e-34 115.4 111.8 6.7e-09 35.4 22.3 5.4 3 2 2 5 5 5 5 Collagen triple helix repeat (20 copies) Vps62 PF06101.11 PIK42495.1 - 3.2e-11 42.2 0.0 4.3e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 ETX_MTX2 PF03318.13 PIK42495.1 - 1.1e-06 28.6 3.5 1.7e-06 28.0 3.5 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK42495.1 - 1.5e-05 24.5 1.4 2.2e-05 23.9 1.4 1.2 1 0 0 1 1 1 1 Aerolysin toxin tRNA-synt_1g PF09334.11 PIK42496.1 - 3.8e-102 342.0 0.1 1.5e-101 340.0 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 PIK42496.1 - 1.8e-17 62.8 8.2 1.2e-07 30.4 0.1 3.5 1 1 2 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 PIK42496.1 - 1.1e-08 34.8 0.0 0.00063 19.2 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain IDO PF01231.18 PIK42496.1 - 0.13 11.0 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase DUF4520 PF15016.6 PIK42497.1 - 8.2e-13 48.3 0.0 9.3e-12 44.9 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4520) IFT20 PF14931.6 PIK42499.1 - 0.035 14.3 0.3 0.16 12.1 0.1 2.0 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Ribosomal_S21 PF01165.20 PIK42501.1 - 2.6 7.8 14.8 61 3.4 0.1 5.5 5 0 0 5 5 5 0 Ribosomal protein S21 TPR_2 PF07719.17 PIK42502.1 - 1.1e-18 65.7 11.4 0.002 18.1 1.1 5.9 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42502.1 - 5e-15 54.6 5.8 0.00078 19.2 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK42502.1 - 3e-13 50.2 1.0 9.4e-05 23.0 0.3 4.1 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42502.1 - 3.5e-12 45.5 5.4 0.0056 16.8 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK42502.1 - 3.8e-10 39.9 10.7 0.002 18.4 2.2 4.8 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK42502.1 - 4.3e-09 36.8 2.7 0.023 15.2 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK42502.1 - 2e-07 31.3 6.0 0.28 12.1 0.0 5.0 2 1 4 6 6 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK42502.1 - 9e-06 25.8 6.4 0.0098 16.1 1.2 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK42502.1 - 1.1e-05 25.1 14.5 0.0083 16.1 0.5 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_21 PF09976.9 PIK42502.1 - 1.2e-05 25.1 0.6 0.0014 18.4 0.2 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 PIK42502.1 - 2.2e-05 23.8 0.5 0.00012 21.4 0.4 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK42502.1 - 5.4e-05 22.7 3.1 0.0017 17.8 2.2 2.7 1 1 1 2 2 2 1 MalT-like TPR region TPR_11 PF13414.6 PIK42502.1 - 0.00013 21.5 8.2 0.016 14.9 0.3 4.3 2 2 2 4 4 4 2 TPR repeat Coatomer_E PF04733.14 PIK42502.1 - 0.00052 19.5 0.2 0.62 9.4 0.1 2.2 1 1 1 2 2 2 2 Coatomer epsilon subunit TPR_6 PF13174.6 PIK42502.1 - 0.00086 19.8 3.2 7.9 7.4 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK42502.1 - 0.001 19.2 4.3 0.0071 16.5 1.3 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK42502.1 - 0.0017 18.6 1.2 17 6.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK42502.1 - 0.0047 16.9 4.0 10 6.3 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK42502.1 - 0.021 15.4 2.2 42 5.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK42502.1 - 0.056 13.5 3.7 6 7.0 0.0 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 PIK42502.1 - 0.082 13.3 0.4 0.23 11.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional activator domain DUF3808 PF10300.9 PIK42502.1 - 0.096 11.4 0.1 0.13 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Coatomer_WDAD PF04053.14 PIK42502.1 - 0.11 11.5 0.3 1.3 8.0 0.1 2.1 2 0 0 2 2 2 0 Coatomer WD associated region TPR_10 PF13374.6 PIK42502.1 - 0.14 12.0 8.6 5.3 7.1 0.4 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK42503.1 - 2e-06 28.3 0.0 0.042 14.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK42503.1 - 0.0081 16.9 0.0 12 7.0 0.0 3.5 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK42503.1 - 0.022 14.9 1.8 3 8.2 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK42503.1 - 0.042 14.2 0.0 6 7.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42503.1 - 0.063 13.1 2.7 1.7 8.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42503.1 - 0.17 12.2 2.5 24 5.5 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DAO PF01266.24 PIK42504.1 - 3.1e-65 221.1 0.0 4e-65 220.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 PIK42504.1 - 8e-05 21.4 0.0 0.21 10.1 0.0 2.3 2 1 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.17 PIK42504.1 - 0.0028 16.9 0.0 0.0054 16.0 0.0 1.5 1 1 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 PIK42504.1 - 0.016 14.5 0.1 0.12 11.6 0.1 2.0 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK42504.1 - 0.019 15.2 0.7 0.043 14.1 0.1 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 PIK42504.1 - 0.042 13.1 0.0 0.074 12.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 PIK42504.1 - 0.085 11.9 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 PIK42504.1 - 0.089 11.8 0.1 0.31 10.1 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein zf-B_box PF00643.24 PIK42505.1 - 2.3e-08 34.1 22.6 3.3e-07 30.3 4.6 3.8 5 0 0 5 5 5 2 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK42505.1 - 0.00011 21.9 2.2 0.00011 21.9 2.2 4.4 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK42505.1 - 0.0023 18.1 2.3 0.0023 18.1 2.3 4.5 4 2 2 6 6 6 1 zinc finger of C3HC4-type, RING CEBP_ZZ PF16366.5 PIK42505.1 - 0.0031 17.7 8.7 0.0031 17.7 8.7 2.9 3 0 0 3 3 3 1 Cytoplasmic polyadenylation element-binding protein ZZ domain Prok-RING_4 PF14447.6 PIK42505.1 - 0.0043 16.9 3.3 0.0043 16.9 3.3 4.2 4 1 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK42505.1 - 0.0087 16.1 2.4 0.0087 16.1 2.4 2.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK42505.1 - 0.029 14.3 2.4 0.029 14.3 2.4 4.4 4 0 0 4 4 4 0 zinc-RING finger domain COMP PF11598.8 PIK42505.1 - 0.25 11.8 0.2 0.25 11.8 0.2 3.5 5 0 0 5 5 5 0 Cartilage oligomeric matrix protein Syntaxin-6_N PF09177.11 PIK42505.1 - 1.1 9.8 4.0 3.3 8.3 0.9 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal SPRY PF00622.28 PIK42506.1 - 1.6e-16 60.5 0.1 5.9e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 SPRY domain fn3 PF00041.21 PIK42506.1 - 0.0041 17.4 0.0 0.023 15.0 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain PRY PF13765.6 PIK42506.1 - 0.027 14.1 0.4 0.14 11.8 0.1 2.3 2 1 1 3 3 3 0 SPRY-associated domain GSHPx PF00255.19 PIK42507.1 - 1.1e-22 79.6 0.3 1.5e-22 79.2 0.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase CytochromB561_N PF09786.9 PIK42508.1 - 0.012 14.6 4.0 0.015 14.4 4.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Sporozoite_P67 PF05642.11 PIK42508.1 - 0.039 12.1 1.1 0.045 11.8 1.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tub_N PF16322.5 PIK42508.1 - 0.11 12.9 5.2 0.15 12.4 5.2 1.2 1 0 0 1 1 1 0 Tubby N-terminal DBC1 PF14443.6 PIK42508.1 - 0.16 12.0 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 DBC1 Bclx_interact PF08945.10 PIK42509.1 - 7.2e-07 28.9 0.3 1.7e-06 27.7 0.3 1.6 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain Bcl-2_BAD PF10514.9 PIK42509.1 - 1.9e-06 28.4 0.8 2.5e-06 28.1 0.7 1.3 1 1 0 1 1 1 1 Pro-apoptotic Bcl-2 protein, BAD C5-epim_C PF06662.13 PIK42510.1 - 3.6e-72 241.8 0.1 5.6e-72 241.2 0.1 1.3 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Pec_lyase PF09492.10 PIK42510.1 - 0.037 13.4 0.2 3.1 7.1 0.1 2.2 2 0 0 2 2 2 0 Pectic acid lyase Glyco_hydro_56 PF01630.18 PIK42511.1 - 3e-101 338.8 0.1 2.1e-81 273.5 0.0 2.1 1 1 1 2 2 2 2 Hyaluronidase EGF_alliinase PF04863.13 PIK42511.1 - 2 8.9 14.1 9.2e+02 0.3 14.1 2.6 1 1 0 1 1 1 0 Alliinase EGF-like domain EGF_2 PF07974.13 PIK42511.1 - 2.8 8.4 20.2 3.1 8.2 7.4 2.5 2 0 0 2 2 2 0 EGF-like domain Glyco_hydro_56 PF01630.18 PIK42512.1 - 2.4e-50 171.4 0.1 2.8e-50 171.2 0.1 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF_2 PF07974.13 PIK42512.1 - 4.7 7.7 19.2 1.1 9.7 4.8 3.1 3 0 0 3 3 3 0 EGF-like domain Glyco_hydro_56 PF01630.18 PIK42513.1 - 1.7e-37 129.2 0.0 2.7e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 Hyaluronidase DUF5522 PF17653.1 PIK42514.1 - 0.15 12.0 0.2 8.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5522) EF-hand_1 PF00036.32 PIK42515.1 - 3.4e-05 23.1 0.2 0.0001 21.6 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 PIK42515.1 - 0.027 14.9 0.1 0.048 14.1 0.1 1.6 1 1 0 1 1 1 0 EF-hand domain pair DUF4468 PF14730.6 PIK42515.1 - 0.027 14.8 0.3 0.048 13.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold EF-hand_5 PF13202.6 PIK42515.1 - 0.033 13.7 0.1 0.093 12.3 0.1 1.8 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 PIK42515.1 - 0.092 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Pkinase PF00069.25 PIK42516.1 - 2.6e-22 79.5 0.0 3.8e-21 75.6 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK42516.1 - 6.4e-11 42.0 0.0 1.2e-07 31.3 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK42516.1 - 0.0015 17.9 0.0 0.0056 16.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK42516.1 - 0.0037 17.2 0.1 0.0067 16.4 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family ASC PF00858.24 PIK42517.1 - 2.7e-62 211.2 4.4 3.3e-62 210.9 4.4 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Condensation PF00668.20 PIK42518.1 - 0.078 11.6 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Condensation domain Glyco_transf_29 PF00777.18 PIK42519.1 - 1.1e-40 139.7 1.4 2.1e-40 138.8 0.1 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) NACHT PF05729.12 PIK42520.1 - 1.2e-12 48.1 0.0 4.9e-12 46.1 0.0 2.0 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 PIK42520.1 - 0.0062 15.8 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK42520.1 - 0.019 14.5 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 PIK42520.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IL17 PF06083.11 PIK42521.1 - 7.4e-10 39.2 1.3 7.4e-10 39.2 1.3 1.7 2 0 0 2 2 2 1 Interleukin-17 MAT1 PF06391.13 PIK42521.1 - 0.0089 15.9 0.2 0.011 15.6 0.2 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 Dehyd-heme_bind PF09098.10 PIK42521.1 - 0.027 14.1 0.2 0.11 12.1 0.0 1.7 1 1 1 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Methyltransf_4 PF02390.17 PIK42523.1 - 5.1e-61 205.1 0.0 6e-61 204.9 0.0 1.0 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 PIK42523.1 - 0.0015 18.1 0.0 0.0083 15.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 PIK42523.1 - 0.0085 16.8 0.0 0.016 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK42523.1 - 0.011 15.5 0.1 0.025 14.4 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK42523.1 - 0.15 11.9 0.0 0.19 11.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain RIC3 PF15361.6 PIK42524.1 - 1.8e-18 67.3 4.4 1.9e-18 67.3 1.3 2.2 2 1 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 DUF948 PF06103.11 PIK42524.1 - 0.38 11.0 1.2 0.7 10.2 1.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) TMEM101 PF15111.6 PIK42525.1 - 2e-12 47.2 0.2 2.4e-12 47.0 0.2 1.0 1 0 0 1 1 1 1 TMEM101 protein family RVT_1 PF00078.27 PIK42526.1 - 1.7e-10 40.8 0.0 2.9e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pep_M12B_propep PF01562.19 PIK42527.1 - 8.4e-39 133.0 1.1 1e-38 132.8 1.1 1.1 1 0 0 1 1 1 1 Reprolysin family propeptide TRAPP PF04051.16 PIK42528.1 - 1.2e-23 83.5 0.1 1.4e-23 83.3 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SelP_N PF04592.14 PIK42530.1 - 2.5e-35 122.0 0.0 3.5e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region EF-hand_7 PF13499.6 PIK42531.1 - 4.1e-05 23.9 0.0 0.025 15.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK42531.1 - 4.4e-05 23.1 0.0 0.027 14.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK42531.1 - 6.7e-05 22.2 0.0 0.15 11.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 PIK42531.1 - 0.00018 20.8 0.0 0.51 9.9 0.0 2.3 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 PIK42531.1 - 0.076 13.3 0.0 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Sushi PF00084.20 PIK42532.1 - 5.1e-42 142.3 14.4 5.5e-11 42.9 0.5 4.6 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) HRM PF02793.22 PIK42532.1 - 2.7e-09 37.2 12.6 0.047 14.0 0.1 4.4 3 1 1 4 4 4 4 Hormone receptor domain DUF281 PF03436.13 PIK42532.1 - 0.01 16.2 6.8 3.1 8.3 1.5 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF281) EGF PF00008.27 PIK42532.1 - 0.048 14.0 8.2 0.048 14.0 8.2 5.1 7 0 0 7 7 7 0 EGF-like domain BslA PF17735.1 PIK42532.1 - 0.071 13.1 0.1 3.9 7.5 0.0 2.6 2 1 1 3 3 3 0 Biofilm surface layer A Diphtheria_R PF01324.19 PIK42532.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Diphtheria toxin, R domain Sushi PF00084.20 PIK42533.1 - 8.2e-153 497.1 107.3 6e-11 42.8 1.7 17.1 17 0 0 17 17 17 17 Sushi repeat (SCR repeat) PPR_1 PF12854.7 PIK42533.1 - 0.093 12.5 0.0 0.48 10.2 0.0 2.2 1 0 0 1 1 1 0 PPR repeat HRM PF02793.22 PIK42533.1 - 0.19 12.0 70.3 2.2 8.6 0.8 13.5 13 1 0 13 13 13 0 Hormone receptor domain EGF_MSP1_1 PF12946.7 PIK42533.1 - 4.5 7.4 6.9 5 7.3 0.1 4.7 4 0 0 4 4 4 0 MSP1 EGF domain 1 Ephrin_rec_like PF07699.13 PIK42534.1 - 4.8e-41 138.3 66.9 1.2e-12 47.4 6.9 7.4 5 2 2 7 7 7 4 Putative ephrin-receptor like Sushi PF00084.20 PIK42534.1 - 3.2e-32 110.9 58.3 2.2e-08 34.6 0.3 9.5 8 1 1 9 9 8 6 Sushi repeat (SCR repeat) HYR PF02494.16 PIK42534.1 - 1.8e-30 105.0 2.3 2e-16 60.1 0.1 2.7 2 0 0 2 2 2 2 HYR domain EGF PF00008.27 PIK42534.1 - 3.7e-23 81.5 104.6 6.7e-07 29.5 4.0 9.7 10 0 0 10 10 8 5 EGF-like domain hEGF PF12661.7 PIK42534.1 - 8.9e-14 51.5 97.4 0.00013 22.5 2.4 10.7 11 0 0 11 11 10 6 Human growth factor-like EGF VWA PF00092.28 PIK42534.1 - 5.9e-13 49.4 0.0 1e-12 48.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Pentaxin PF00354.17 PIK42534.1 - 2.8e-07 30.4 0.3 6.4e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Pentaxin family Laminin_G_3 PF13385.6 PIK42534.1 - 2.6e-06 27.7 0.1 5.5e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_CA PF07645.15 PIK42534.1 - 0.0011 19.1 11.9 0.0011 19.1 11.9 13.5 11 3 3 14 14 12 5 Calcium-binding EGF domain EGF_2 PF07974.13 PIK42534.1 - 0.14 12.6 104.7 0.12 12.8 5.4 9.6 7 0 0 7 7 6 0 EGF-like domain EGF_3 PF12947.7 PIK42534.1 - 0.8 10.0 96.8 0.052 13.8 6.8 9.7 9 2 1 10 10 10 0 EGF domain Kinesin PF00225.23 PIK42535.1 - 5.9e-97 324.6 0.4 5.9e-97 324.6 0.4 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK42535.1 - 6.2e-17 61.9 1.6 9.9e-17 61.3 0.1 2.2 2 0 0 2 2 2 1 Microtubule binding Type2_restr_D3 PF16902.5 PIK42535.1 - 0.01 15.7 4.4 0.062 13.2 0.1 3.6 4 0 0 4 4 4 0 Type-2 restriction enzyme D3 domain PIN_4 PF13638.6 PIK42535.1 - 0.84 9.9 5.9 0.11 12.8 0.8 2.0 2 0 0 2 2 2 0 PIN domain DFF-C PF09033.10 PIK42535.1 - 3 7.7 9.3 0.48 10.3 4.1 2.2 2 1 0 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain LRAT PF04970.13 PIK42536.1 - 0.00087 19.6 5.4 0.00087 19.6 5.4 1.7 1 1 1 2 2 2 1 Lecithin retinol acyltransferase WSD PF15613.6 PIK42536.1 - 0.061 13.8 0.3 0.14 12.6 0.2 1.6 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Antimicrobial24 PF16049.5 PIK42537.1 - 0.0067 16.4 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Frog antimicrobial peptide LRAT PF04970.13 PIK42537.1 - 0.041 14.2 1.2 0.23 11.8 0.1 2.2 1 1 1 2 2 2 0 Lecithin retinol acyltransferase LRAT PF04970.13 PIK42538.1 - 4.4e-08 33.5 1.9 0.00025 21.3 0.6 2.4 2 0 0 2 2 2 2 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK42538.1 - 0.00027 20.8 0.7 0.35 10.7 0.0 2.5 2 0 0 2 2 2 2 PPPDE putative peptidase domain DUF778 PF05608.12 PIK42538.1 - 0.0012 19.2 0.4 0.046 14.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF778) DUF5634_N PF18672.1 PIK42538.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5634) Pam17 PF08566.10 PIK42538.1 - 2.1 8.2 6.0 0.23 11.3 0.4 2.2 2 1 1 3 3 3 0 Mitochondrial import protein Pam17 DUF1943 PF09172.11 PIK42539.1 - 2.1e-54 184.9 0.0 5.7e-54 183.5 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) SSF PF00474.17 PIK42541.1 - 1.4e-29 103.2 15.3 1.8e-29 102.8 15.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Vps5 PF09325.10 PIK42543.1 - 0.0043 16.6 4.7 0.21 11.1 4.7 2.2 1 1 0 1 1 1 1 Vps5 C terminal like GrpE PF01025.19 PIK42543.1 - 0.01 15.5 0.6 0.018 14.7 0.6 1.4 1 0 0 1 1 1 1 GrpE DUF4140 PF13600.6 PIK42543.1 - 0.027 14.9 0.0 0.043 14.3 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CLZ PF16526.5 PIK42543.1 - 0.048 14.0 0.2 0.23 11.8 0.1 2.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ceramidase_alk PF04734.13 PIK42544.1 - 1e-194 647.9 0.0 1.2e-194 647.7 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 PIK42544.1 - 1.2e-15 57.8 0.0 2.3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Ceramidase_alk PF04734.13 PIK42545.1 - 1.4e-207 690.3 0.0 1.7e-207 690.1 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 PIK42545.1 - 5.8e-28 97.9 0.0 8.7e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal HLH PF00010.26 PIK42546.1 - 1e-15 57.4 0.1 2.1e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Anth_Ig PF05587.13 PIK42547.1 - 5.1e-27 94.2 1.2 9.3e-27 93.3 1.2 1.4 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.28 PIK42547.1 - 1.1e-23 84.3 0.4 2.3e-23 83.3 0.5 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain Ant_C PF05586.11 PIK42547.1 - 2e-16 60.3 0.7 2.7e-14 53.5 0.7 2.3 1 1 0 1 1 1 1 Anthrax receptor C-terminus region VWA_2 PF13519.6 PIK42547.1 - 5.5e-14 52.7 0.0 1.3e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK42547.1 - 1.3e-05 24.7 0.2 2.3e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein TIG PF01833.24 PIK42547.1 - 0.00034 20.6 2.4 0.00079 19.5 2.4 1.7 1 0 0 1 1 1 1 IPT/TIG domain vWA-TerF-like PF10138.9 PIK42547.1 - 0.05 13.7 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus Anth_Ig PF05587.13 PIK42548.1 - 2.3e-21 76.0 2.8 4.4e-21 75.1 2.8 1.5 1 0 0 1 1 1 1 Anthrax receptor extracellular domain Ant_C PF05586.11 PIK42548.1 - 3.3e-09 37.2 0.0 8.1e-09 36.0 0.0 1.7 1 1 0 1 1 1 1 Anthrax receptor C-terminus region VWA PF00092.28 PIK42548.1 - 1.2e-07 32.1 0.0 1.8e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK42548.1 - 0.041 14.5 0.0 0.078 13.6 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK42548.1 - 0.089 12.2 0.2 0.16 11.3 0.2 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein BK_channel_a PF03493.18 PIK42549.1 - 5.7e-33 113.0 0.0 1.3e-32 111.8 0.0 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 PIK42549.1 - 2.6e-07 30.9 0.0 0.00013 22.2 0.0 3.0 3 0 0 3 3 3 2 TrkA-N domain NOD2_WH PF17779.1 PIK42549.1 - 0.41 11.0 2.0 38 4.7 0.0 3.3 4 0 0 4 4 4 0 NOD2 winged helix domain GTA_holin_3TM PF11351.8 PIK42550.1 - 0.098 13.2 0.0 3.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release T3SS_TC PF06511.11 PIK42550.1 - 9.4 5.5 7.1 26 4.1 0.3 2.9 2 1 1 3 3 3 0 Type III secretion systems tip complex components E1_dh PF00676.20 PIK42551.1 - 4.7e-55 186.7 0.1 5.3e-49 166.8 0.7 2.3 2 0 0 2 2 2 2 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 PIK42551.1 - 5.2e-52 175.6 0.0 9.2e-52 174.8 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal Transket_pyr PF02779.24 PIK42551.1 - 2.2e-47 161.0 0.0 9.1e-39 133.0 0.0 2.4 1 1 1 2 2 2 2 Transketolase, pyrimidine binding domain WD40 PF00400.32 PIK42552.1 - 3.5e-41 138.4 24.5 3e-08 34.2 0.2 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK42552.1 - 1e-05 25.8 0.3 1.3 9.3 0.0 4.1 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK42552.1 - 0.00036 19.3 6.3 0.022 13.5 0.1 3.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK42552.1 - 0.0045 16.4 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Metallophos PF00149.28 PIK42553.1 - 9.5e-35 121.0 1.1 1.4e-34 120.4 1.0 1.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 PIK42553.1 - 0.0077 15.9 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain AhpC-TSA_2 PF13911.6 PIK42554.1 - 7.6e-08 32.5 0.1 1.2e-07 31.9 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 PIK42554.1 - 0.043 13.7 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family WW PF00397.26 PIK42555.1 - 0.3 11.2 10.6 0.05 13.7 4.4 2.5 2 0 0 2 2 2 0 WW domain PfkB PF00294.24 PIK42558.1 - 8.6e-14 51.5 0.0 1e-13 51.3 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase PfkB PF00294.24 PIK42559.1 - 4.8e-30 104.9 0.4 6.1e-30 104.6 0.4 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Endostatin PF06482.11 PIK42559.1 - 0.15 11.5 11.2 0.17 11.3 11.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Carb_anhydrase PF00194.21 PIK42560.1 - 5e-28 98.3 0.0 5.5e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase SRCR PF00530.18 PIK42561.1 - 1.7e-08 34.9 0.4 1.7e-08 34.9 0.4 1.7 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Somatomedin_B PF01033.17 PIK42561.1 - 7.2e-07 29.5 18.3 7.2e-07 29.5 18.3 2.0 2 0 0 2 2 2 1 Somatomedin B domain SRCR_2 PF15494.6 PIK42561.1 - 8.7e-05 23.0 0.1 0.00018 22.0 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain 7tm_2 PF00002.24 PIK42563.1 - 2.4e-09 36.9 21.1 3.8e-09 36.2 21.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) SRCR PF00530.18 PIK42563.1 - 1.7e-06 28.4 1.5 3.8e-06 27.3 0.3 2.4 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Somatomedin_B PF01033.17 PIK42563.1 - 6e-06 26.6 18.1 6e-06 26.6 18.1 3.7 4 0 0 4 4 4 1 Somatomedin B domain Methyltransf_23 PF13489.6 PIK42564.1 - 4.1e-05 23.5 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK42564.1 - 0.0072 17.0 0.0 0.016 15.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 PIK42564.1 - 0.0079 15.9 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Trimer_CC PF08954.11 PIK42565.1 - 0.37 10.4 3.6 3.7 7.2 0.1 3.2 3 0 0 3 3 3 0 Trimerisation motif Ifi-6-16 PF06140.13 PIK42566.1 - 4e-18 65.1 29.7 4.9e-18 64.8 29.7 1.1 1 0 0 1 1 1 1 Interferon-induced 6-16 family DctA-YdbH PF11739.8 PIK42566.1 - 0.15 11.7 0.3 0.17 11.6 0.3 1.1 1 0 0 1 1 1 0 Dicarboxylate transport zf-H2C2_2 PF13465.6 PIK42568.1 - 1e-07 32.0 20.5 0.0012 19.2 0.6 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK42568.1 - 1.8e-06 28.3 21.3 0.014 16.2 6.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK42568.1 - 2.7e-06 27.5 26.8 0.015 15.7 0.1 3.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type PyrI_C PF02748.15 PIK42568.1 - 0.0072 16.2 3.9 0.76 9.7 0.3 2.4 2 0 0 2 2 2 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF3268 PF11672.8 PIK42568.1 - 0.097 13.0 0.5 0.097 13.0 0.5 2.9 2 2 1 3 3 3 0 zinc-finger-containing domain zf-BED PF02892.15 PIK42568.1 - 0.45 10.6 11.4 1.5 8.9 0.6 2.7 2 0 0 2 2 2 0 BED zinc finger zf-Di19 PF05605.12 PIK42568.1 - 0.5 10.7 4.8 3.6 7.9 0.6 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 PIK42569.1 - 2.6e-11 43.3 30.7 0.0011 19.3 1.0 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42569.1 - 1.2e-09 38.1 31.0 0.024 15.5 0.7 5.3 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 PIK42569.1 - 2.9e-09 37.0 15.6 0.0033 17.8 0.2 5.0 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK42569.1 - 2.7e-06 27.5 18.8 0.013 15.8 0.2 5.2 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK42569.1 - 1.4e-05 25.3 29.5 0.016 15.6 1.0 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK42569.1 - 1.9e-05 24.5 25.1 0.31 11.1 0.5 5.3 4 1 1 5 5 5 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK42569.1 - 0.01 15.6 0.1 0.01 15.6 0.1 3.5 5 0 0 5 5 5 0 zinc-finger C2H2-type PyrI_C PF02748.15 PIK42569.1 - 0.041 13.8 0.1 0.041 13.8 0.1 4.3 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF629 PF04780.12 PIK42569.1 - 1.1 7.7 16.9 0.14 10.6 0.4 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF629) Ogr_Delta PF04606.12 PIK42569.1 - 1.4 9.0 7.5 12 6.0 0.3 3.2 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2_3rep PF18868.1 PIK42569.1 - 1.4 9.6 11.9 0.41 11.3 2.6 2.6 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 PIK42569.1 - 1.5 9.5 12.1 4.7 7.9 1.4 3.7 2 1 2 4 4 4 0 FOXP coiled-coil domain Elf1 PF05129.13 PIK42569.1 - 5.6 7.1 20.3 0.24 11.5 3.3 3.7 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like Bcl-2_BAD PF10514.9 PIK42570.1 - 0.15 12.5 2.7 0.17 12.3 1.3 1.7 1 1 1 2 2 2 0 Pro-apoptotic Bcl-2 protein, BAD CDC45 PF02724.14 PIK42570.1 - 3.3 5.9 9.7 4.2 5.5 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.7 PIK42570.1 - 4.8 7.9 19.6 0.59 10.8 15.5 1.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Proteasome PF00227.26 PIK42571.1 - 2.6e-39 134.7 1.1 2.9e-39 134.5 1.1 1.0 1 0 0 1 1 1 1 Proteasome subunit RT_RNaseH_2 PF17919.1 PIK42574.1 - 7.2e-27 93.4 0.0 1.4e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42574.1 - 1.1e-23 83.6 0.0 2e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK42574.1 - 1e-16 60.7 0.8 1.8e-16 59.9 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Patched PF02460.18 PIK42575.1 - 1.2e-19 69.9 34.4 7.2e-18 64.1 2.1 2.7 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 PIK42575.1 - 1.2e-12 47.9 11.7 1.2e-12 47.9 11.7 2.6 2 1 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK42575.1 - 0.0066 15.4 42.4 0.011 14.7 21.5 2.5 2 1 0 2 2 2 2 MMPL family LRR_6 PF13516.6 PIK42576.1 - 1.7e-21 74.4 4.2 7.1e-05 22.5 0.0 5.4 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 PIK42576.1 - 2.7e-08 34.0 1.0 0.011 16.2 0.1 3.9 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK42576.1 - 1.4e-05 24.7 3.8 0.033 14.0 0.0 4.4 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 PIK42576.1 - 2.8e-05 24.1 0.2 11 7.0 0.0 5.0 5 0 0 5 5 5 1 Leucine Rich Repeat Baculo_gp41 PF04700.12 PIK42576.1 - 0.073 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region LRR_6 PF13516.6 PIK42577.1 - 3.9e-08 32.7 0.8 0.00064 19.6 0.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeat TPR_2 PF07719.17 PIK42578.1 - 2.8e-11 42.6 0.0 0.0092 16.0 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK42578.1 - 2.2e-09 36.7 0.0 0.012 15.4 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK42578.1 - 2.9e-07 30.2 0.0 0.1 12.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK42578.1 - 1.5e-05 25.4 0.0 0.00014 22.3 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK42578.1 - 2.6e-05 24.3 0.0 0.01 16.2 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK42578.1 - 3e-05 23.7 0.0 0.34 11.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK42578.1 - 0.00018 21.1 0.0 0.0015 18.2 0.0 2.5 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 PIK42578.1 - 0.0018 18.5 0.0 1.5 9.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK42578.1 - 0.0076 16.9 0.0 0.05 14.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK42578.1 - 0.018 15.8 0.0 1.9 9.5 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 PIK42578.1 - 0.028 14.4 0.1 2.4 8.2 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF627) TPR_10 PF13374.6 PIK42578.1 - 0.038 13.9 0.2 1.3 9.0 0.2 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK42578.1 - 0.042 14.0 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat KH_1 PF00013.29 PIK42579.1 - 7.5e-138 448.5 47.2 1.6e-13 50.3 0.6 14.7 13 1 1 14 14 14 14 KH domain KH_2 PF07650.17 PIK42579.1 - 2e-14 53.2 25.7 0.072 12.9 0.2 9.1 9 1 0 9 9 9 5 KH domain SLS PF14611.6 PIK42579.1 - 1e-11 45.1 16.0 7.4e-05 22.7 0.1 7.1 5 2 2 8 8 8 5 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 PIK42579.1 - 0.00044 20.1 18.8 0.23 11.3 0.0 7.8 8 1 0 8 8 8 2 KH domain SH3_15 PF18346.1 PIK42579.1 - 0.035 14.4 0.2 1.9 8.9 0.0 3.6 4 0 0 4 4 4 0 Mind bomb SH3 repeat domain KH_5 PF13184.6 PIK42579.1 - 0.085 13.0 29.7 3.2 7.9 0.1 8.7 8 1 1 9 9 9 0 NusA-like KH domain Ku_C PF03730.14 PIK42579.1 - 0.87 10.3 5.4 1.1 10.0 0.1 4.0 5 0 0 5 5 5 0 Ku70/Ku80 C-terminal arm rve PF00665.26 PIK42582.1 - 1.6e-15 57.3 0.1 5.5e-15 55.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK42582.1 - 0.0039 17.4 0.5 0.011 16.0 0.5 1.8 1 0 0 1 1 1 1 DDE domain Glyco_hydro_18 PF00704.28 PIK42583.1 - 0.12 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 DNA_pol_B_2 PF03175.13 PIK42584.1 - 4.5e-07 29.1 3.2 6.9e-07 28.5 3.2 1.2 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral MULE PF10551.9 PIK42585.1 - 5.7e-13 49.1 0.3 1.6e-12 47.7 0.3 1.8 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 PIK42585.1 - 1.7e-07 31.3 0.8 4e-07 30.1 0.8 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain PHD PF00628.29 PIK42585.1 - 2.1e-05 24.3 6.0 2.1e-05 24.3 6.0 1.9 2 0 0 2 2 2 1 PHD-finger DDE_Tnp_ISL3 PF01610.17 PIK42585.1 - 0.017 14.9 0.6 0.045 13.5 0.3 1.8 1 1 0 1 1 1 0 Transposase Prok-RING_1 PF14446.6 PIK42585.1 - 0.069 13.1 3.1 0.17 11.8 3.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Peptidase_C48 PF02902.19 PIK42586.1 - 2.9e-15 56.7 0.5 6.4e-15 55.6 0.5 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain MULE PF10551.9 PIK42586.1 - 1.1e-10 41.8 0.4 3.9e-10 40.0 0.3 2.1 2 0 0 2 2 2 1 MULE transposase domain PHD PF00628.29 PIK42586.1 - 0.00042 20.2 8.4 0.00042 20.2 8.4 2.3 2 0 0 2 2 2 1 PHD-finger PFK PF00365.20 PIK42587.1 - 1e-11 44.7 0.2 1.2e-11 44.5 0.2 1.0 1 0 0 1 1 1 1 Phosphofructokinase SAC3 PF12209.8 PIK42588.1 - 0.019 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Leucine permease transcriptional regulator helical domain AAA_16 PF13191.6 PIK42590.1 - 0.00052 20.4 0.0 0.00092 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK42590.1 - 0.0016 18.7 0.0 0.0038 17.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK42590.1 - 0.0048 16.8 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 PIK42590.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF4056 PF13265.6 PIK42590.1 - 0.033 13.5 0.1 0.045 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) AAA_5 PF07728.14 PIK42590.1 - 0.045 13.8 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF853 PF05872.12 PIK42590.1 - 0.049 12.2 0.0 0.068 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DAP3 PF10236.9 PIK42590.1 - 0.057 12.6 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 IstB_IS21 PF01695.17 PIK42590.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein SWIB PF02201.18 PIK42590.1 - 0.081 12.8 0.2 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 SWIB/MDM2 domain ABC_tran PF00005.27 PIK42590.1 - 0.1 13.1 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 PIK42590.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 PIK42590.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2791 PF10923.8 PIK42590.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Cytokin_check_N PF10407.9 PIK42590.1 - 0.16 12.0 0.3 31 4.6 0.1 3.3 2 1 1 3 3 3 0 Cdc14 phosphatase binding protein N-terminus DUF2075 PF09848.9 PIK42590.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) EzrA PF06160.12 PIK42591.1 - 0.00085 17.6 10.0 0.00095 17.5 10.0 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA GIT_CC PF16559.5 PIK42591.1 - 0.019 14.8 0.9 0.019 14.8 0.9 2.6 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0242 PF06785.11 PIK42591.1 - 0.022 14.9 13.7 0.029 14.5 13.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1699 PF08004.11 PIK42591.1 - 0.026 14.2 2.7 0.027 14.2 1.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1699) Exonuc_VII_L PF02601.15 PIK42591.1 - 0.091 12.3 6.6 0.1 12.1 6.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit IFT57 PF10498.9 PIK42591.1 - 0.14 11.1 14.4 0.28 10.1 14.4 1.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 AbiH PF14253.6 PIK42591.1 - 0.2 11.5 4.4 0.24 11.2 4.4 1.1 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Moulting_cycle PF04870.16 PIK42591.1 - 0.24 10.6 9.0 0.31 10.3 9.0 1.1 1 0 0 1 1 1 0 Moulting cycle HSCB_C PF07743.13 PIK42591.1 - 0.48 10.9 11.4 0.052 14.0 4.4 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain kleA_kleC PF17383.2 PIK42591.1 - 0.73 10.2 4.6 0.82 10.0 2.8 2.1 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A Cauli_AT PF03233.13 PIK42591.1 - 1.3 9.0 9.8 0.27 11.2 0.9 2.2 1 1 1 2 2 2 0 Aphid transmission protein SlyX PF04102.12 PIK42591.1 - 1.4 9.6 16.7 0.89 10.2 4.0 3.3 1 1 2 3 3 3 0 SlyX BORCS7 PF16088.5 PIK42591.1 - 1.6 9.0 9.2 0.45 10.8 1.6 2.2 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 7 TMF_TATA_bd PF12325.8 PIK42591.1 - 1.8 8.8 14.5 1 9.6 11.4 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding AAA_23 PF13476.6 PIK42591.1 - 3 8.3 11.5 4.1 7.9 11.5 1.3 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 PIK42591.1 - 6.3 6.9 9.6 2.6 8.1 2.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Med9 PF07544.13 PIK42591.1 - 6.6 6.9 16.2 0.46 10.6 4.1 2.9 1 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Pkinase_Tyr PF07714.17 PIK42593.1 - 6.2e-14 51.9 2.1 4.3e-06 26.2 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK42593.1 - 4.1e-10 39.5 1.3 7.8e-05 22.2 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain C2-set_2 PF08205.12 PIK42593.1 - 4.9e-09 36.1 0.7 1.7e-08 34.4 0.7 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK42593.1 - 8.3e-05 23.1 0.9 8.3e-05 23.1 0.9 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK42593.1 - 0.0044 17.3 0.3 0.015 15.6 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK42593.1 - 0.046 13.9 0.4 0.11 12.6 0.4 1.7 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK42593.1 - 0.054 13.6 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK42594.1 - 6e-10 39.1 0.7 8.1e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Pentaxin PF00354.17 PIK42594.1 - 0.018 14.7 0.1 0.027 14.1 0.1 1.2 1 0 0 1 1 1 0 Pentaxin family Sulfotransfer_1 PF00685.27 PIK42595.1 - 1.3e-09 37.9 0.1 1.6e-09 37.7 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain TSP_C PF05735.12 PIK42596.1 - 1.3e-31 110.1 0.0 2e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Thrombospondin C-terminal region Laminin_G_3 PF13385.6 PIK42596.1 - 2.2e-24 86.3 0.2 4.4e-24 85.4 0.2 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Fumarate_red_C PF02300.17 PIK42596.1 - 0.23 11.6 0.2 0.38 10.8 0.2 1.3 1 0 0 1 1 1 0 Fumarate reductase subunit C LRR_8 PF13855.6 PIK42597.1 - 4.1e-32 109.7 51.8 7.3e-10 38.5 7.7 5.8 3 2 3 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 PIK42597.1 - 7.3e-19 68.0 25.7 3e-10 40.1 2.0 2.9 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK42597.1 - 3e-09 37.0 36.8 7.5e-06 26.2 2.5 7.0 3 3 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK42597.1 - 6.3e-06 25.8 9.8 0.008 15.7 0.8 3.4 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 PIK42597.1 - 0.031 14.8 24.6 13 6.8 0.1 9.0 8 2 1 9 9 9 0 Leucine Rich Repeat Macscav_rec PF03523.13 PIK42597.1 - 0.15 12.0 1.9 1.4 8.9 0.8 2.5 2 0 0 2 2 2 0 Macrophage scavenger receptor LRR_6 PF13516.6 PIK42597.1 - 0.76 10.0 21.2 5.5 7.3 0.0 6.7 7 0 0 7 7 7 0 Leucine Rich repeat Ephrin PF00812.17 PIK42598.1 - 2.1e-29 102.3 0.0 2.9e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Ephrin E3_UbLigase_RBR PF18091.1 PIK42598.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 E3 Ubiquitin Ligase RBR C-terminal domain AAA_11 PF13086.6 PIK42599.1 - 6.3e-58 196.6 0.2 9.4e-57 192.8 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 PIK42599.1 - 7.6e-55 185.6 0.0 1.3e-54 184.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain R3H PF01424.22 PIK42599.1 - 7.8e-14 51.4 0.1 2.1e-13 50.0 0.1 1.7 1 0 0 1 1 1 1 R3H domain AAA_30 PF13604.6 PIK42599.1 - 8.4e-14 51.7 0.1 1.8e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK42599.1 - 7.7e-09 36.0 0.2 5.1e-08 33.4 0.1 2.4 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 PIK42599.1 - 3.8e-08 33.4 1.1 0.13 12.0 0.1 4.2 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 PIK42599.1 - 7.3e-05 23.2 0.2 0.00019 21.8 0.2 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK42599.1 - 0.00011 22.5 0.1 0.00051 20.3 0.0 2.3 2 1 0 2 2 1 1 AAA domain ResIII PF04851.15 PIK42599.1 - 0.00025 21.1 0.0 0.00063 19.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 PIK42599.1 - 0.00039 20.8 1.5 0.0012 19.3 0.8 2.2 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.14 PIK42599.1 - 0.0011 19.0 0.1 0.0022 18.0 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain Helicase_RecD PF05127.14 PIK42599.1 - 0.0019 18.1 0.0 0.012 15.5 0.0 2.3 3 0 0 3 3 3 1 Helicase PhoH PF02562.16 PIK42599.1 - 0.0024 17.3 0.0 0.006 16.1 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein T2SSE PF00437.20 PIK42599.1 - 0.003 16.6 0.0 0.007 15.5 0.0 1.5 2 0 0 2 2 1 1 Type II/IV secretion system protein Rad17 PF03215.15 PIK42599.1 - 0.014 15.3 0.0 0.068 13.1 0.0 2.0 1 1 0 1 1 1 0 Rad17 P-loop domain IstB_IS21 PF01695.17 PIK42599.1 - 0.016 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DnaB_C PF03796.15 PIK42599.1 - 0.016 14.6 0.0 0.032 13.6 0.0 1.5 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain NTPase_1 PF03266.15 PIK42599.1 - 0.025 14.5 0.1 0.06 13.3 0.1 1.7 1 0 0 1 1 1 0 NTPase UvrD-helicase PF00580.21 PIK42599.1 - 0.03 13.8 0.1 0.08 12.4 0.1 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain cobW PF02492.19 PIK42599.1 - 0.031 13.8 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 PIK42599.1 - 0.039 14.5 0.2 4.1 7.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 PIK42599.1 - 0.045 13.5 0.2 0.11 12.3 0.2 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_33 PF13671.6 PIK42599.1 - 0.05 13.8 0.1 0.12 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 PIK42599.1 - 0.054 12.7 0.5 0.17 11.1 0.2 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.6 PIK42599.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain MeaB PF03308.16 PIK42599.1 - 0.063 12.3 0.0 1 8.3 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 PIK42599.1 - 0.076 13.5 0.7 0.53 10.8 0.0 2.7 2 2 0 2 2 2 0 ABC transporter Zot PF05707.12 PIK42599.1 - 0.077 12.6 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_25 PF13481.6 PIK42599.1 - 0.086 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Herpes_ori_bp PF02399.15 PIK42599.1 - 0.1 10.6 0.0 0.15 10.1 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein Herpes_Helicase PF02689.14 PIK42599.1 - 0.11 10.4 0.0 0.15 10.0 0.0 1.2 1 0 0 1 1 1 0 Helicase ATPase PF06745.13 PIK42599.1 - 0.11 11.9 0.0 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 KaiC CbiA PF01656.23 PIK42599.1 - 0.12 12.4 0.1 0.25 11.4 0.1 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RuvB_N PF05496.12 PIK42599.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MIF PF01187.18 PIK42600.1 - 0.0049 17.1 0.0 0.0057 16.9 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Haemocyan_bet_s PF14830.6 PIK42600.1 - 0.052 13.5 0.0 0.062 13.3 0.0 1.2 1 0 0 1 1 1 0 Haemocyanin beta-sandwich zf-C3HC4 PF00097.25 PIK42601.1 - 7.6e-05 22.5 19.4 7.6e-05 22.5 19.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK42601.1 - 0.00046 20.0 14.6 0.00046 20.0 14.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK42601.1 - 0.0011 19.1 11.6 0.0011 19.1 11.6 2.9 4 0 0 4 4 4 1 B-box zinc finger zf-RING_UBOX PF13445.6 PIK42601.1 - 0.0019 18.2 24.0 0.002 18.1 10.0 3.8 3 2 0 3 3 3 2 RING-type zinc-finger zf-RING_5 PF14634.6 PIK42601.1 - 0.0025 17.8 16.3 0.0025 17.8 16.3 2.5 2 1 0 2 2 2 1 zinc-RING finger domain Herpes_UL92 PF03048.14 PIK42601.1 - 0.027 14.3 0.6 0.027 14.3 0.6 1.7 2 0 0 2 2 2 0 UL92 family DivIVA PF05103.13 PIK42601.1 - 0.58 10.2 6.3 0.22 11.6 3.7 1.6 2 0 0 2 2 2 0 DivIVA protein zf-C3HC4_4 PF15227.6 PIK42601.1 - 0.88 9.8 26.2 0.16 12.1 18.2 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK42602.1 - 3.3e-06 26.9 9.6 3.3e-06 26.9 9.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK42602.1 - 9.9e-06 25.3 13.1 9.9e-06 25.3 13.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK42602.1 - 5.9e-05 23.0 11.0 5.9e-05 23.0 11.0 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK42602.1 - 0.00014 21.9 5.7 0.00014 21.9 5.7 3.4 3 1 0 3 3 3 1 RING-type zinc-finger HAP1_N PF04849.13 PIK42602.1 - 0.00032 20.0 1.0 0.00032 20.0 1.0 2.0 1 1 1 2 2 2 1 HAP1 N-terminal conserved region zf-C3HC4_4 PF15227.6 PIK42602.1 - 0.00058 20.0 13.2 0.00058 20.0 13.2 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK42602.1 - 0.0008 19.5 9.7 0.0008 19.5 9.7 2.7 3 0 0 3 3 2 1 B-box zinc finger Tup_N PF08581.10 PIK42602.1 - 0.004 17.4 0.2 0.013 15.8 0.2 1.9 1 0 0 1 1 1 1 Tup N-terminal BLOC1_2 PF10046.9 PIK42602.1 - 0.0082 16.4 1.0 0.068 13.5 0.0 2.4 2 1 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prok-RING_4 PF14447.6 PIK42602.1 - 0.0099 15.7 10.8 0.0099 15.7 10.8 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 SMG1 PF15785.5 PIK42602.1 - 0.059 11.8 0.4 0.089 11.2 0.4 1.2 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 Syntaxin PF00804.25 PIK42602.1 - 0.076 12.7 4.2 0.14 11.8 4.2 1.4 1 1 0 1 1 1 0 Syntaxin RPW8 PF05659.11 PIK42602.1 - 0.08 12.6 4.4 0.059 13.1 1.3 2.3 2 1 0 2 2 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 KxDL PF10241.9 PIK42602.1 - 0.083 13.2 0.0 1.7 9.0 0.0 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein CEP63 PF17045.5 PIK42602.1 - 0.12 12.3 4.7 0.3 11.0 4.9 1.6 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa TPR_MLP1_2 PF07926.12 PIK42602.1 - 0.12 12.4 3.4 0.099 12.7 1.5 1.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.11 PIK42602.1 - 0.28 11.5 1.3 37 4.7 0.6 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 PIK42602.1 - 1.1 9.5 9.1 0.66 10.2 3.2 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spectrin PF00435.21 PIK42602.1 - 2.4 8.7 5.0 5.6 7.5 0.2 2.6 2 1 1 3 3 2 0 Spectrin repeat p450 PF00067.22 PIK42604.1 - 1.5e-85 287.7 0.0 1.8e-85 287.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sulfotransfer_2 PF03567.14 PIK42605.1 - 1.4e-15 57.9 4.2 1.8e-15 57.5 4.2 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK42605.1 - 3.6e-06 26.6 0.3 1.2e-05 25.0 0.1 1.8 1 1 0 2 2 2 1 Sulfotransferase domain Gal-3-0_sulfotr PF06990.11 PIK42605.1 - 0.00079 18.4 0.4 0.0015 17.5 0.4 1.4 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase HYR PF02494.16 PIK42606.1 - 8.9e-113 368.8 42.4 1.1e-19 70.6 0.1 8.1 8 0 0 8 8 8 8 HYR domain DUF5011 PF16403.5 PIK42606.1 - 0.0012 18.9 1.0 68 3.7 0.0 5.6 6 0 0 6 6 6 1 Domain of unknown function (DUF5011) MgsA_C PF12002.8 PIK42607.1 - 6.1e-36 123.9 0.0 9.9e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 PIK42607.1 - 3.9e-27 94.4 0.2 8.7e-27 93.3 0.2 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 PIK42607.1 - 1.7e-14 54.4 0.8 4.2e-14 53.1 0.1 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 PIK42607.1 - 1.2e-13 51.1 0.0 2.2e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK42607.1 - 6.4e-09 35.9 0.0 1.3e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 PIK42607.1 - 4.1e-06 26.3 0.4 0.0021 17.5 0.1 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 PIK42607.1 - 4.2e-06 26.6 0.2 0.0031 17.2 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain TIP49 PF06068.13 PIK42607.1 - 1.7e-05 24.2 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 PIK42607.1 - 3.4e-05 23.9 0.0 6.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK42607.1 - 0.00015 22.3 0.0 0.00044 20.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK42607.1 - 0.00031 20.5 0.0 0.00065 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK42607.1 - 0.00047 20.6 0.5 0.0079 16.6 0.2 2.4 1 1 1 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 PIK42607.1 - 0.00047 19.4 0.3 0.0027 16.9 0.1 2.0 1 1 1 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 PIK42607.1 - 0.00089 19.5 0.9 0.014 15.7 0.2 2.4 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK42607.1 - 0.00092 19.4 0.1 0.002 18.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 PIK42607.1 - 0.0016 18.2 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein RNF220 PF15926.5 PIK42607.1 - 0.0028 17.3 1.3 0.0028 17.3 1.3 2.5 2 1 1 3 3 3 1 E3 ubiquitin-protein ligase RNF220 AAA_33 PF13671.6 PIK42607.1 - 0.0041 17.3 0.0 0.014 15.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 PIK42607.1 - 0.0042 17.0 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DnaB_C PF03796.15 PIK42607.1 - 0.0091 15.4 0.1 0.017 14.5 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Rad17 PF03215.15 PIK42607.1 - 0.011 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_19 PF13245.6 PIK42607.1 - 0.012 15.9 0.3 0.032 14.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 PIK42607.1 - 0.014 14.5 0.0 0.023 13.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 PIK42607.1 - 0.014 14.9 0.1 0.025 14.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 PIK42607.1 - 0.016 14.7 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 PIK42607.1 - 0.019 15.3 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 PIK42607.1 - 0.022 14.7 0.4 0.12 12.3 0.2 2.1 1 1 1 2 2 2 0 NTPase Sigma54_activ_2 PF14532.6 PIK42607.1 - 0.025 14.7 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 PIK42607.1 - 0.026 13.8 0.1 0.065 12.5 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin KTI12 PF08433.10 PIK42607.1 - 0.03 13.8 0.1 0.081 12.4 0.1 1.7 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.12 PIK42607.1 - 0.034 14.1 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 PIK42607.1 - 0.036 14.5 0.3 0.32 11.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 PIK42607.1 - 0.041 14.4 1.4 0.058 13.9 0.1 1.9 2 0 0 2 2 1 0 ABC transporter Helicase_RecD PF05127.14 PIK42607.1 - 0.049 13.5 0.2 0.1 12.4 0.2 1.6 1 1 0 1 1 1 0 Helicase zf-WRNIP1_ubi PF18279.1 PIK42607.1 - 0.053 14.2 0.0 0.053 14.2 0.0 2.3 3 0 0 3 3 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf_UBZ PF18439.1 PIK42607.1 - 0.14 11.8 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger Macoilin PF09726.9 PIK42607.1 - 0.35 9.4 4.8 0.51 8.8 4.8 1.2 1 0 0 1 1 1 0 Macoilin family zf-H2C2_2 PF13465.6 PIK42610.1 - 2.4e-88 286.9 103.6 1.8e-09 37.6 0.9 11.0 11 0 0 11 11 11 11 Zinc-finger double domain zf-C2H2 PF00096.26 PIK42610.1 - 4.4e-50 165.4 99.7 1.4e-05 25.3 3.7 11.1 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42610.1 - 1e-40 134.8 89.9 0.00028 21.5 0.9 11.1 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK42610.1 - 2.9e-20 72.0 78.6 0.0089 16.3 0.7 11.1 10 1 1 11 11 11 9 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK42610.1 - 3.6e-17 62.0 70.6 0.076 12.9 0.5 11.2 10 1 1 11 11 11 10 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK42610.1 - 2.2e-15 56.1 49.2 0.00017 21.3 0.2 10.4 11 0 0 11 11 11 7 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 PIK42610.1 - 6.8e-15 54.5 50.1 0.032 14.2 0.1 11.4 11 0 0 11 11 11 7 zinc-finger of a C2HC-type zf-AN1 PF01428.16 PIK42610.1 - 2.9e-07 30.6 63.4 3.6 7.8 0.3 11.2 9 1 2 11 11 11 4 AN1-like Zinc finger zf-C2H2_6 PF13912.6 PIK42610.1 - 9.5e-07 28.7 87.3 1 9.4 2.1 11.8 11 0 0 11 11 11 7 C2H2-type zinc finger zf-BED PF02892.15 PIK42610.1 - 0.00014 21.8 76.7 2 8.5 3.6 11.1 1 1 10 11 11 11 6 BED zinc finger zf-Di19 PF05605.12 PIK42610.1 - 0.00023 21.4 65.6 0.36 11.1 3.1 8.2 1 1 9 10 10 10 6 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.12 PIK42610.1 - 0.00055 20.1 62.0 0.051 13.8 3.5 7.5 1 1 6 8 8 8 5 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 PIK42610.1 - 0.0017 19.1 59.7 0.4 11.4 3.0 6.0 3 1 5 8 8 8 5 zinc-ribbon family zf-C2HE PF16278.5 PIK42610.1 - 0.0095 16.4 77.7 0.66 10.5 2.4 10.9 1 1 10 11 11 11 4 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 PIK42610.1 - 0.0098 15.5 59.4 2.7 7.7 0.2 10.9 11 0 0 11 11 11 3 Ubiquitin-Binding Zinc Finger Glyco_hydro_2_C PF02836.17 PIK42610.1 - 0.011 14.9 27.8 0.09 11.9 4.9 4.6 1 1 4 5 5 5 0 Glycosyl hydrolases family 2, TIM barrel domain zf-CHCC PF10276.9 PIK42610.1 - 0.03 14.4 76.6 2.6 8.1 0.6 11.1 11 0 0 11 11 11 0 Zinc-finger domain GAGA PF09237.11 PIK42610.1 - 0.06 13.2 28.3 0.44 10.4 0.6 7.3 2 2 7 9 9 9 0 GAGA factor AsiA PF09010.10 PIK42610.1 - 0.073 13.2 1.9 35 4.6 0.0 4.1 3 2 3 6 6 4 0 Anti-Sigma Factor A zf-Dof PF02701.15 PIK42610.1 - 0.085 13.0 52.5 1.2 9.3 0.3 9.9 1 1 7 9 9 9 0 Dof domain, zinc finger EKAL PF17986.1 PIK42610.1 - 0.17 11.9 31.7 7.1 6.7 0.1 8.1 3 3 5 8 8 8 0 EMP3-KAHRP-like N-terminal domain BolA PF01722.18 PIK42610.1 - 0.21 11.9 18.1 3.1 8.2 0.2 5.3 3 3 2 5 5 5 0 BolA-like protein Yippee-Mis18 PF03226.14 PIK42610.1 - 0.37 11.0 40.9 0.86 9.8 3.7 7.3 2 1 5 7 7 7 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly BHD_1 PF10403.9 PIK42610.1 - 0.48 10.3 5.1 9 6.2 0.1 4.0 3 3 0 3 3 3 0 Rad4 beta-hairpin domain 1 zf-met PF12874.7 PIK42610.1 - 0.54 10.7 86.7 1.4 9.4 1.3 11.2 11 0 0 11 11 11 0 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 PIK42610.1 - 2.2 9.0 38.1 1.3 9.7 8.3 6.7 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats Scramblase PF03803.15 PIK42610.1 - 3.3 6.9 10.9 2.4 7.4 0.4 3.1 2 1 1 3 3 3 0 Scramblase Baculo_IE-1 PF05290.11 PIK42610.1 - 4.1 7.3 45.6 16 5.4 0.4 9.2 1 1 9 10 10 10 0 Baculovirus immediate-early protein (IE-0) DUF3268 PF11672.8 PIK42610.1 - 5.1 7.4 55.3 0.81 10.0 3.9 5.9 2 1 4 7 7 7 0 zinc-finger-containing domain zf-H2C2_2 PF13465.6 PIK42611.1 - 3.1e-49 163.3 53.1 6.9e-10 38.9 2.7 6.1 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK42611.1 - 1.3e-33 113.6 45.5 7.1e-07 29.3 1.2 6.0 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42611.1 - 9.2e-23 79.0 40.7 0.0007 20.2 0.9 6.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK42611.1 - 1.3e-15 57.2 36.4 0.0066 16.7 0.8 6.1 6 0 0 6 6 6 6 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK42611.1 - 9.5e-12 44.5 19.5 0.022 14.6 0.2 6.2 6 0 0 6 6 6 4 zinc-finger of a C2HC-type PyrI_C PF02748.15 PIK42611.1 - 7.4e-11 41.8 40.8 0.068 13.1 1.6 6.1 3 3 3 6 6 6 6 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK42611.1 - 3e-09 36.5 13.6 0.96 9.3 0.0 6.1 6 0 0 6 6 6 2 zinc-finger C2H2-type DUF3268 PF11672.8 PIK42611.1 - 3.9e-08 33.6 19.9 0.0056 17.0 1.7 3.1 3 0 0 3 3 3 3 zinc-finger-containing domain zf-met PF12874.7 PIK42611.1 - 2e-07 31.2 41.0 0.089 13.2 1.0 6.3 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2HE PF16278.5 PIK42611.1 - 5.7e-07 29.9 32.3 0.22 12.0 0.8 6.1 1 1 5 6 6 6 3 C2HE / C2H2 / C2HC zinc-binding finger zf-CHCC PF10276.9 PIK42611.1 - 1.9e-06 27.8 40.6 0.55 10.3 1.5 6.2 6 0 0 6 6 6 5 Zinc-finger domain zf-AN1 PF01428.16 PIK42611.1 - 2.7e-05 24.2 33.1 2.7 8.2 0.3 6.2 5 1 1 6 6 6 2 AN1-like Zinc finger zf-BED PF02892.15 PIK42611.1 - 3.2e-05 23.8 33.1 0.53 10.4 0.7 6.2 1 1 5 6 6 6 2 BED zinc finger C1_1 PF00130.22 PIK42611.1 - 4.3e-05 23.3 22.6 0.44 10.5 1.6 5.4 1 1 5 6 6 6 5 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_4 PF07975.12 PIK42611.1 - 0.0001 22.5 29.5 0.046 14.0 3.4 4.7 1 1 4 5 5 5 4 TFIIH C1-like domain zf-C2H2_6 PF13912.6 PIK42611.1 - 0.0008 19.3 49.7 0.28 11.2 0.9 7.5 7 1 0 7 7 7 3 C2H2-type zinc finger EKAL PF17986.1 PIK42611.1 - 0.0018 18.3 14.1 9.5 6.3 0.0 5.6 3 1 3 6 6 6 0 EMP3-KAHRP-like N-terminal domain zf_C2HC_14 PF18574.1 PIK42611.1 - 0.0022 17.8 25.6 0.25 11.2 0.1 6.5 6 1 0 6 6 6 1 C2HC Zing finger domain DUF1294 PF06961.13 PIK42611.1 - 0.003 17.7 0.7 5.7 7.3 0.0 4.1 5 0 0 5 5 4 0 Protein of unknown function (DUF1294) Glyco_hydro_2_C PF02836.17 PIK42611.1 - 0.0037 16.4 7.7 0.093 11.8 0.7 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 2, TIM barrel domain zf_UBZ PF18439.1 PIK42611.1 - 0.0044 16.6 22.2 0.3 10.7 0.1 5.9 6 0 0 6 6 6 2 Ubiquitin-Binding Zinc Finger YyzF PF14116.6 PIK42611.1 - 0.0047 16.9 24.4 10 6.2 0.2 6.0 6 0 0 6 6 6 0 YyzF-like protein PHF5 PF03660.14 PIK42611.1 - 0.012 15.7 12.2 1.2 9.4 0.4 3.1 1 1 2 3 3 3 0 PHF5-like protein CpXC PF14353.6 PIK42611.1 - 0.018 15.1 22.4 5.1 7.2 0.2 5.8 6 0 0 6 6 6 0 CpXC protein zf-Di19 PF05605.12 PIK42611.1 - 0.043 14.1 30.5 0.36 11.2 4.7 4.7 1 1 4 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 PIK42611.1 - 0.046 14.0 14.0 42 4.5 0.0 5.8 5 1 1 6 6 6 0 zinc-ribbon zinc_ribbon_15 PF17032.5 PIK42611.1 - 0.049 14.4 25.2 1.2 10.0 2.6 3.2 1 1 1 3 3 3 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 PIK42611.1 - 0.052 13.3 18.1 9.6 6.1 0.0 5.9 6 0 0 6 6 6 0 zinc-ribbon domain Zf_RING PF16744.5 PIK42611.1 - 0.054 13.6 22.5 7.1 6.8 0.4 5.9 1 1 5 6 6 6 0 KIAA1045 RING finger HNH PF01844.23 PIK42611.1 - 0.095 12.9 24.7 6 7.1 0.2 6.0 6 0 0 6 6 6 0 HNH endonuclease zinc-ribbons_6 PF07191.12 PIK42611.1 - 0.11 12.5 28.8 16 5.6 5.0 5.5 1 1 3 4 4 4 0 zinc-ribbons DUF3280 PF11684.8 PIK42611.1 - 0.12 12.7 13.5 28 5.1 0.1 5.4 1 1 5 6 6 6 0 Protein of unknown function (DUF2380) Yippee-Mis18 PF03226.14 PIK42611.1 - 0.23 11.7 18.3 4.4 7.6 5.0 4.6 1 1 3 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-U1 PF06220.12 PIK42611.1 - 0.29 11.0 0.3 0.29 11.0 0.3 6.6 5 1 1 6 6 6 0 U1 zinc finger Baculo_IE-1 PF05290.11 PIK42611.1 - 0.33 10.9 20.3 17 5.3 0.1 5.5 1 1 5 6 6 6 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_2 PF12756.7 PIK42611.1 - 0.47 10.8 32.5 6.4 7.2 0.6 5.9 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 PIK42611.1 - 0.48 10.2 66.3 0.17 11.6 1.4 7.5 6 3 0 6 6 6 0 C2H2-type zinc-finger domain zf-Dof PF02701.15 PIK42611.1 - 0.7 10.1 23.1 1.2 9.3 3.0 5.4 1 1 3 4 4 4 0 Dof domain, zinc finger C1-set PF07654.15 PIK42611.1 - 2.8 8.4 10.3 12 6.4 0.2 3.5 1 1 2 4 4 4 0 Immunoglobulin C1-set domain PHD PF00628.29 PIK42611.1 - 5.3 7.0 31.6 2.9 7.9 4.9 4.7 2 1 2 4 4 4 0 PHD-finger zf-H2C2_2 PF13465.6 PIK42612.1 - 3.5e-88 286.4 107.1 6.6e-09 35.8 0.9 11.1 11 0 0 11 11 11 11 Zinc-finger double domain zf-C2H2 PF00096.26 PIK42612.1 - 4.8e-52 171.6 95.4 1e-05 25.7 4.3 10.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42612.1 - 1.2e-37 125.3 85.1 0.0015 19.2 1.5 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK42612.1 - 4.2e-18 65.1 73.7 0.0034 17.6 2.8 10.2 10 0 0 10 10 10 9 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK42612.1 - 3.6e-15 55.4 41.3 0.2 11.6 0.1 10.6 10 0 0 10 10 10 7 zinc-finger of a C2HC-type PyrI_C PF02748.15 PIK42612.1 - 1e-12 47.7 69.9 0.11 12.4 0.4 10.5 9 2 2 11 11 11 9 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK42612.1 - 2e-09 37.0 35.7 0.27 11.0 0.0 9.9 10 0 0 10 10 10 4 zinc-finger C2H2-type C1_4 PF07975.12 PIK42612.1 - 2.1e-09 37.5 50.7 0.0024 18.1 2.1 7.3 1 1 4 7 7 7 3 TFIIH C1-like domain zf-C2HE PF16278.5 PIK42612.1 - 1.9e-07 31.4 67.7 0.065 13.7 0.6 10.0 1 1 8 9 9 9 3 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 PIK42612.1 - 2.4e-07 30.9 79.9 0.064 13.7 3.1 10.3 10 0 0 10 10 10 6 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK42612.1 - 3.8e-07 30.0 68.8 0.83 9.7 3.9 10.3 1 1 9 10 10 10 5 BED zinc finger zf-AN1 PF01428.16 PIK42612.1 - 6.4e-06 26.2 61.3 2.7 8.2 0.2 10.4 7 1 3 10 10 10 2 AN1-like Zinc finger Yippee-Mis18 PF03226.14 PIK42612.1 - 0.0001 22.4 30.9 2 8.7 4.3 8.1 3 1 5 8 8 8 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly GAGA PF09237.11 PIK42612.1 - 0.00012 21.8 17.9 0.035 13.9 0.1 6.1 2 2 6 8 8 8 2 GAGA factor Glyco_hydro_2_C PF02836.17 PIK42612.1 - 0.00023 20.4 21.7 0.11 11.6 3.5 3.7 1 1 2 3 3 3 2 Glycosyl hydrolases family 2, TIM barrel domain EKAL PF17986.1 PIK42612.1 - 0.00042 20.3 36.9 1.8 8.7 0.9 9.0 4 3 5 9 9 9 2 EMP3-KAHRP-like N-terminal domain zf-C2H2_6 PF13912.6 PIK42612.1 - 0.00043 20.2 92.5 0.092 12.8 0.9 11.7 10 2 0 10 10 10 5 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 PIK42612.1 - 0.00068 20.3 49.5 0.96 10.2 2.8 5.4 1 1 1 5 5 5 4 zinc-ribbon family DUF3268 PF11672.8 PIK42612.1 - 0.00069 19.9 46.9 0.5 10.7 3.0 5.4 2 1 1 5 5 5 4 zinc-finger-containing domain FYDLN_acid PF09538.10 PIK42612.1 - 0.011 16.4 27.5 15 6.3 0.2 8.3 2 2 6 8 8 8 0 Protein of unknown function (FYDLN_acid) Zf_RING PF16744.5 PIK42612.1 - 0.012 15.7 44.0 12 6.1 0.2 9.7 1 1 9 10 10 10 0 KIAA1045 RING finger zf-Di19 PF05605.12 PIK42612.1 - 0.057 13.7 63.5 3 8.2 4.3 8.2 1 1 7 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding Baculo_IE-1 PF05290.11 PIK42612.1 - 0.13 12.2 41.3 6.9 6.6 0.6 8.8 1 1 9 10 10 10 0 Baculovirus immediate-early protein (IE-0) XPA_N PF01286.18 PIK42612.1 - 0.14 12.2 31.6 22 5.2 0.1 9.5 10 0 0 10 10 10 0 XPA protein N-terminal zf-U1 PF06220.12 PIK42612.1 - 0.2 11.5 66.4 0.42 10.4 0.9 10.5 9 1 1 10 10 10 0 U1 zinc finger zf_UBZ PF18439.1 PIK42612.1 - 0.5 10.0 45.5 3.4 7.4 0.7 9.6 10 0 0 10 10 10 0 Ubiquitin-Binding Zinc Finger zf-CHCC PF10276.9 PIK42612.1 - 1.5 9.0 69.2 1.4 9.1 1.2 10.3 10 0 0 10 10 10 0 Zinc-finger domain BolA PF01722.18 PIK42612.1 - 1.7 9.0 17.7 31 4.9 5.4 4.6 3 2 1 4 4 4 0 BolA-like protein zinc-ribbons_6 PF07191.12 PIK42612.1 - 4.3 7.4 53.1 28 4.8 0.4 9.0 1 1 6 7 7 6 0 zinc-ribbons zf-C2H2_2 PF12756.7 PIK42612.1 - 9.2 6.7 66.1 3.2 8.1 0.8 9.5 1 1 9 10 10 10 0 C2H2 type zinc-finger (2 copies) zf-Dof PF02701.15 PIK42612.1 - 10 6.4 46.9 3.6 7.8 2.6 8.3 1 1 6 7 7 7 0 Dof domain, zinc finger MULE PF10551.9 PIK42613.1 - 1e-08 35.4 0.1 1e-08 35.4 0.1 2.0 2 0 0 2 2 2 1 MULE transposase domain SWIM PF04434.17 PIK42613.1 - 0.032 13.9 0.5 0.076 12.7 0.5 1.7 1 0 0 1 1 1 0 SWIM zinc finger TIR PF01582.20 PIK42613.1 - 0.052 13.3 0.9 0.18 11.6 0.3 2.1 2 0 0 2 2 2 0 TIR domain HTH_Tnp_4 PF13613.6 PIK42613.1 - 0.19 11.5 0.5 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease Peptidase_C48 PF02902.19 PIK42614.1 - 7.4e-18 65.2 1.4 7.4e-18 65.2 1.4 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain PHD PF00628.29 PIK42614.1 - 2.2e-05 24.2 9.2 5e-05 23.1 9.2 1.6 1 0 0 1 1 1 1 PHD-finger MULE PF10551.9 PIK42615.1 - 2.4e-17 63.1 0.1 2.4e-17 63.1 0.1 1.9 2 0 0 2 2 2 1 MULE transposase domain DUF1247 PF06851.11 PIK42615.1 - 0.025 14.5 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) SWIM PF04434.17 PIK42615.1 - 0.034 13.8 0.5 0.062 13.0 0.5 1.5 1 0 0 1 1 1 0 SWIM zinc finger Orbi_VP2 PF00898.17 PIK42615.1 - 0.046 11.5 0.1 0.054 11.3 0.1 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP2 DDE_Tnp_IS240 PF13610.6 PIK42615.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 DDE domain Bacillus_HBL PF05791.11 PIK42615.1 - 0.11 12.4 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Trigger_C PF05698.14 PIK42616.1 - 0.13 12.3 0.0 13 5.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus NACHT PF05729.12 PIK42617.1 - 8.4e-18 64.8 0.0 2.1e-17 63.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK42617.1 - 0.00013 21.3 0.0 0.00025 20.3 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK42617.1 - 0.0022 17.6 0.0 0.0051 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK42617.1 - 0.0053 17.0 0.0 0.015 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Shisa PF13908.6 PIK42617.1 - 0.11 12.7 0.4 0.22 11.7 0.4 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Adeno_E3_CR2 PF02439.15 PIK42617.1 - 1.2 8.9 10.0 3 7.7 10.0 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 GPI2 PF06432.11 PIK42617.1 - 5.2 6.4 7.3 1.8 7.9 0.5 2.5 2 1 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase NTP_transf_2 PF01909.23 PIK42618.1 - 3.1e-09 37.0 0.0 6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 PIK42618.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DUF5601 PF18151.1 PIK42618.1 - 0.11 12.8 0.0 0.38 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) FixS PF03597.15 PIK42619.1 - 6.7 6.5 5.6 0.76 9.5 1.2 1.7 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type SPRY PF00622.28 PIK42620.1 - 5.2e-20 71.8 0.4 1e-19 70.8 0.4 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 PIK42620.1 - 1.2e-09 37.9 13.5 1.7e-09 37.3 11.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK42620.1 - 0.00044 20.1 11.4 0.00094 19.0 11.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4541 PF15074.6 PIK42621.1 - 1.1e-35 122.0 0.5 1.6e-35 121.6 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4541) HD-ZIP_N PF04618.12 PIK42621.1 - 0.064 13.8 0.1 0.091 13.3 0.1 1.2 1 0 0 1 1 1 0 HD-ZIP protein N terminus Raftlin PF15250.6 PIK42624.1 - 2.2e-07 30.0 0.0 0.00035 19.4 0.0 2.1 2 0 0 2 2 2 2 Raftlin DUF4177 PF13783.6 PIK42624.1 - 1.6e-05 25.1 0.0 0.16 12.2 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4177) OLF PF02191.16 PIK42625.1 - 9.6e-35 120.3 0.4 1.5e-34 119.6 0.4 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Flagellin_N PF00669.20 PIK42625.1 - 0.094 12.8 5.9 0.093 12.8 4.1 1.9 2 1 0 2 2 2 0 Bacterial flagellin N-terminal helical region FlxA PF14282.6 PIK42625.1 - 0.96 9.5 4.7 0.91 9.5 0.7 2.6 2 1 0 2 2 2 0 FlxA-like protein PX PF00787.24 PIK42626.1 - 4e-13 49.3 1.5 6.5e-13 48.7 1.5 1.3 1 0 0 1 1 1 1 PX domain TPR_12 PF13424.6 PIK42626.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Vps51 PF08700.11 PIK42626.1 - 0.19 11.8 0.0 0.49 10.5 0.0 1.6 1 0 0 1 1 1 0 Vps51/Vps67 EGF PF00008.27 PIK42627.1 - 4.3e-07 30.1 23.5 5.1e-05 23.5 8.7 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 PIK42627.1 - 0.0003 20.9 17.9 0.0054 16.9 5.2 2.9 1 1 1 2 2 2 2 EGF domain hEGF PF12661.7 PIK42627.1 - 0.0012 19.4 6.2 0.0012 19.4 6.2 4.1 4 1 0 4 4 4 2 Human growth factor-like EGF zf-C3H1 PF10650.9 PIK42627.1 - 0.17 11.7 0.5 0.17 11.7 0.5 3.4 4 1 0 4 4 4 0 Putative zinc-finger domain EGF PF00008.27 PIK42628.1 - 9.6e-09 35.4 27.5 5.9e-07 29.7 6.3 3.0 3 0 0 3 3 3 2 EGF-like domain Laminin_G_2 PF02210.24 PIK42628.1 - 1.6e-06 28.8 0.2 2.3e-06 28.2 0.2 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK42628.1 - 5.7e-05 23.3 0.0 7.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 PIK42628.1 - 0.00012 22.6 25.6 0.0018 18.8 3.8 4.4 3 1 0 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK42628.1 - 0.011 16.0 8.8 0.011 16.0 8.8 3.5 4 1 0 4 4 4 0 EGF-like domain EGF_CA PF07645.15 PIK42628.1 - 0.027 14.7 12.4 0.027 14.7 12.4 3.6 2 1 1 3 3 3 0 Calcium-binding EGF domain EGF_3 PF12947.7 PIK42628.1 - 0.038 14.2 5.7 0.038 14.2 5.7 3.1 2 1 0 2 2 2 0 EGF domain Laminin_G_2 PF02210.24 PIK42629.1 - 4.3e-11 43.5 0.1 1.9e-08 34.9 0.1 2.2 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 PIK42629.1 - 9.7e-11 41.8 30.8 2.1e-06 27.9 9.7 3.5 3 1 0 3 3 3 2 EGF-like domain Laminin_G_1 PF00054.23 PIK42629.1 - 5.5e-10 39.6 0.0 1.4e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF_2 PF07974.13 PIK42629.1 - 0.00029 21.2 34.7 0.037 14.4 14.0 3.0 2 1 0 2 2 2 2 EGF-like domain EGF_alliinase PF04863.13 PIK42629.1 - 0.26 11.7 20.0 0.084 13.3 4.0 2.7 2 1 0 2 2 2 0 Alliinase EGF-like domain EGF_3 PF12947.7 PIK42629.1 - 0.7 10.1 33.4 1.6 9.0 7.5 4.3 3 2 1 4 4 4 0 EGF domain Laminin_EGF PF00053.24 PIK42629.1 - 3 8.0 28.8 5.3 7.3 8.3 2.7 2 1 0 2 2 2 0 Laminin EGF domain EGF PF00008.27 PIK42630.1 - 1.5e-32 111.5 67.9 2.5e-07 30.9 8.3 6.3 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK42630.1 - 1.5e-19 69.9 59.9 2.2e-07 31.3 4.8 7.9 6 2 0 6 6 6 6 Human growth factor-like EGF EGF_2 PF07974.13 PIK42630.1 - 4.9e-09 36.4 72.2 0.021 15.2 4.3 6.4 5 1 1 6 6 6 6 EGF-like domain EGF_3 PF12947.7 PIK42630.1 - 1.5e-08 34.7 58.7 0.053 13.7 8.1 7.0 5 3 2 7 7 7 5 EGF domain FXa_inhibition PF14670.6 PIK42630.1 - 7.4e-07 29.3 66.5 0.58 10.5 3.6 6.6 2 2 4 6 6 6 4 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK42630.1 - 0.018 15.2 77.2 0.76 10.0 0.1 6.7 4 2 2 6 6 6 0 Calcium-binding EGF domain Laminin_EGF PF00053.24 PIK42630.1 - 0.13 12.4 67.6 2.5 8.3 9.1 6.5 2 2 4 6 6 6 0 Laminin EGF domain zf-CCCH PF00642.24 PIK42630.1 - 4.4 7.3 17.5 4.6 7.3 0.2 5.4 5 0 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EGF PF00008.27 PIK42631.1 - 8.5e-23 80.3 83.3 1.9e-06 28.1 7.1 6.3 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 PIK42631.1 - 2.8e-07 30.9 83.7 0.0025 18.4 4.6 8.7 10 1 0 10 10 10 5 Human growth factor-like EGF EGF_CA PF07645.15 PIK42631.1 - 0.00015 21.9 8.0 0.00015 21.9 8.0 6.5 2 2 4 6 6 6 3 Calcium-binding EGF domain EGF_2 PF07974.13 PIK42631.1 - 0.0086 16.4 92.0 0.032 14.6 11.2 6.3 6 0 0 6 6 6 3 EGF-like domain Syndecan PF01034.20 PIK42631.1 - 0.017 15.0 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Syndecan domain DUF3185 PF11381.8 PIK42631.1 - 0.031 14.3 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) TMEM154 PF15102.6 PIK42631.1 - 0.033 14.1 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 PIK42631.1 - 0.11 13.4 0.1 0.19 12.6 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PEMT PF04191.13 PIK42631.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Phospholipid methyltransferase Stevor PF17410.2 PIK42631.1 - 6.5 6.2 4.9 4.8 6.6 3.2 1.5 1 1 0 2 2 2 0 Subtelomeric Variable Open Reading frame AAA_5 PF07728.14 PIK42632.1 - 8e-121 398.4 0.0 7.5e-23 81.0 0.0 8.5 8 0 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 PIK42632.1 - 7.5e-43 145.1 0.2 1.1e-16 60.9 0.1 6.0 5 0 0 5 5 5 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 PIK42632.1 - 4.3e-30 103.9 0.1 7.6e-29 99.9 0.0 3.1 3 0 0 3 3 2 1 Midasin AAA lid domain AAA_3 PF07726.11 PIK42632.1 - 3.3e-28 98.2 0.0 1.1e-09 38.3 0.0 6.9 6 1 0 6 6 6 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK42632.1 - 1.2e-27 97.4 13.3 8.9e-06 26.2 0.1 7.8 6 1 1 7 7 7 6 AAA ATPase domain AAA_7 PF12775.7 PIK42632.1 - 3.5e-27 95.1 2.5 2.1e-05 24.1 0.0 6.6 6 0 0 6 6 6 5 P-loop containing dynein motor region AAA PF00004.29 PIK42632.1 - 5.3e-27 94.8 1.6 2.3e-05 24.8 0.0 7.2 6 1 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 PIK42632.1 - 2.7e-19 69.4 0.0 6.5e-05 23.0 0.0 6.6 7 0 0 7 7 6 4 Dynein heavy chain region D6 P-loop domain AAA_18 PF13238.6 PIK42632.1 - 8.6e-18 65.1 6.8 0.0039 17.7 0.0 7.2 7 0 0 7 7 6 3 AAA domain Sigma54_activat PF00158.26 PIK42632.1 - 3.6e-17 62.6 0.4 0.037 13.7 0.0 6.8 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_22 PF13401.6 PIK42632.1 - 3.9e-17 62.8 8.2 0.0011 19.2 0.0 7.5 7 1 0 7 7 6 3 AAA domain AAA_14 PF13173.6 PIK42632.1 - 1e-16 61.1 0.0 0.02 14.9 0.0 6.9 7 0 0 7 7 6 3 AAA domain ABC_tran PF00005.27 PIK42632.1 - 4.5e-16 59.6 4.4 0.0081 16.7 0.0 7.2 7 0 0 7 7 6 3 ABC transporter Sigma54_activ_2 PF14532.6 PIK42632.1 - 1.1e-15 57.9 2.3 0.00096 19.3 0.0 6.7 6 0 0 6 6 6 2 Sigma-54 interaction domain TsaE PF02367.17 PIK42632.1 - 1.4e-15 57.4 4.9 0.27 11.3 0.0 6.4 6 0 0 6 6 6 5 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_6 PF12774.7 PIK42632.1 - 7.2e-15 54.8 0.2 0.023 13.7 0.0 7.7 8 0 0 8 8 8 2 Hydrolytic ATP binding site of dynein motor region AAA_30 PF13604.6 PIK42632.1 - 7.8e-15 55.1 0.0 0.0095 15.7 0.0 7.0 7 0 0 7 7 7 2 AAA domain NACHT PF05729.12 PIK42632.1 - 4e-12 46.4 3.9 0.18 11.7 0.0 6.4 6 0 0 6 6 6 3 NACHT domain RsgA_GTPase PF03193.16 PIK42632.1 - 2.9e-11 43.6 4.2 0.094 12.6 0.0 6.4 6 0 0 6 6 6 2 RsgA GTPase RNA_helicase PF00910.22 PIK42632.1 - 8e-11 42.3 1.3 1.7 9.0 0.0 6.7 6 0 0 6 6 6 1 RNA helicase AAA_33 PF13671.6 PIK42632.1 - 1.3e-10 41.6 0.5 0.26 11.4 0.0 6.6 6 0 0 6 6 6 1 AAA domain Zeta_toxin PF06414.12 PIK42632.1 - 1.5e-10 40.7 0.8 0.00088 18.6 0.0 5.9 6 0 0 6 6 6 1 Zeta toxin AAA_8 PF12780.7 PIK42632.1 - 1.6e-10 40.8 0.1 0.16 11.3 0.0 5.7 5 0 0 5 5 5 2 P-loop containing dynein motor region D4 DUF815 PF05673.13 PIK42632.1 - 6.4e-10 38.6 2.8 0.048 12.8 0.0 5.9 6 0 0 6 6 6 2 Protein of unknown function (DUF815) PduV-EutP PF10662.9 PIK42632.1 - 9.3e-09 35.2 3.8 0.13 12.0 0.0 6.3 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 PIK42632.1 - 2.3e-08 34.0 4.0 0.5 10.1 0.0 7.8 9 0 0 9 9 8 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 PIK42632.1 - 6e-07 29.1 0.0 2.2 7.6 0.0 5.7 6 0 0 6 6 5 1 Bacterial TniB protein Roc PF08477.13 PIK42632.1 - 9.8e-07 29.0 5.1 11 6.3 0.0 6.3 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 PIK42632.1 - 1.3e-06 27.7 0.0 0.071 12.2 0.0 4.5 4 0 0 4 4 4 1 MCM P-loop domain AAA_25 PF13481.6 PIK42632.1 - 1.4e-06 28.0 8.3 0.59 9.7 0.0 5.7 6 0 0 6 6 6 2 AAA domain IstB_IS21 PF01695.17 PIK42632.1 - 1.6e-06 28.0 1.2 0.46 10.2 0.0 5.9 6 0 0 6 6 5 1 IstB-like ATP binding protein MMR_HSR1 PF01926.23 PIK42632.1 - 1.8e-06 28.0 1.2 3.9 7.6 0.0 5.5 5 0 0 5 5 5 0 50S ribosome-binding GTPase Mg_chelatase PF01078.21 PIK42632.1 - 2e-06 27.3 5.6 6.1 6.2 0.0 8.1 8 1 1 9 9 8 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 PIK42632.1 - 2e-06 27.4 3.4 28 4.6 0.0 6.5 6 0 0 6 6 6 0 P-loop containing region of AAA domain AAA_28 PF13521.6 PIK42632.1 - 3.3e-05 24.2 8.7 1.5 9.0 0.0 6.3 6 0 0 6 6 6 1 AAA domain SRP54 PF00448.22 PIK42632.1 - 7.7e-05 22.4 7.9 1.2 8.7 0.2 5.7 6 0 0 6 6 5 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 PIK42632.1 - 8.6e-05 22.9 12.2 1.3 9.3 0.3 6.1 7 1 0 7 7 4 1 AAA domain DEAD PF00270.29 PIK42632.1 - 9.2e-05 22.3 2.0 10 5.9 0.0 5.3 5 0 0 5 5 5 0 DEAD/DEAH box helicase Rad17 PF03215.15 PIK42632.1 - 0.00023 21.2 9.5 4 7.3 0.1 5.7 6 1 0 6 6 5 0 Rad17 P-loop domain CPT PF07931.12 PIK42632.1 - 0.00029 20.7 4.8 15 5.4 0.0 6.6 7 1 0 7 7 5 0 Chloramphenicol phosphotransferase-like protein ATPase PF06745.13 PIK42632.1 - 0.00047 19.6 0.2 3 7.1 0.0 4.1 4 0 0 4 4 4 0 KaiC TIP49 PF06068.13 PIK42632.1 - 0.0012 18.2 3.4 0.25 10.5 0.1 4.5 5 0 0 5 5 4 1 TIP49 P-loop domain ATP_bind_1 PF03029.17 PIK42632.1 - 0.0025 17.6 5.4 8.2 6.1 0.1 5.0 5 0 0 5 5 4 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.18 PIK42632.1 - 0.0032 17.2 0.4 12 5.5 0.0 4.3 5 0 0 5 5 4 0 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 PIK42632.1 - 0.0049 16.9 2.2 7.1 6.6 0.0 5.0 5 1 0 5 5 5 0 Type III restriction enzyme, res subunit dNK PF01712.19 PIK42632.1 - 0.0049 16.8 5.6 32 4.3 0.1 5.7 6 0 0 6 6 6 0 Deoxynucleoside kinase PhoH PF02562.16 PIK42632.1 - 0.0061 16.0 0.7 37 3.7 0.0 4.7 5 0 0 5 5 5 0 PhoH-like protein AAA_24 PF13479.6 PIK42632.1 - 0.0077 16.0 8.2 7.6 6.2 0.2 5.7 7 1 0 7 7 7 0 AAA domain NTPase_1 PF03266.15 PIK42632.1 - 0.013 15.5 4.3 19 5.1 0.0 5.1 5 0 0 5 5 5 0 NTPase cobW PF02492.19 PIK42632.1 - 0.017 14.7 8.0 6.1 6.4 0.0 4.6 5 0 0 5 5 4 0 CobW/HypB/UreG, nucleotide-binding domain HEAT_EZ PF13513.6 PIK42632.1 - 0.026 15.0 2.2 8.8 7.0 0.2 3.3 3 0 0 3 3 2 0 HEAT-like repeat IPT PF01745.16 PIK42632.1 - 0.035 13.5 1.6 38 3.6 0.0 4.3 4 0 0 4 4 4 0 Isopentenyl transferase KAP_NTPase PF07693.14 PIK42632.1 - 0.048 12.9 0.0 8 5.6 0.0 4.0 5 1 0 5 5 5 0 KAP family P-loop domain AAA_21 PF13304.6 PIK42632.1 - 0.048 13.5 0.0 10 5.8 0.0 3.9 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system CbiA PF01656.23 PIK42632.1 - 0.05 13.7 2.3 15 5.7 0.0 4.3 5 0 0 5 5 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Adaptin_N PF01602.20 PIK42632.1 - 0.09 11.3 0.3 0.16 10.5 0.3 1.3 1 0 0 1 1 1 0 Adaptin N terminal region AAA_23 PF13476.6 PIK42632.1 - 0.2 12.1 22.5 4.6 7.7 0.0 7.2 6 2 0 6 6 4 0 AAA domain Ras PF00071.22 PIK42632.1 - 0.25 10.9 4.1 60 3.2 0.0 4.8 5 0 0 5 5 5 0 Ras family DnaB_C PF03796.15 PIK42632.1 - 0.34 10.2 5.4 11 5.3 0.0 4.2 4 1 0 5 5 4 0 DnaB-like helicase C terminal domain DUF87 PF01935.17 PIK42632.1 - 0.63 10.1 5.5 8.3 6.4 0.1 4.4 5 0 0 5 5 3 0 Helicase HerA, central domain FeoB_N PF02421.18 PIK42632.1 - 0.7 9.4 4.5 49 3.4 0.1 4.5 5 0 0 5 5 5 0 Ferrous iron transport protein B AAA_11 PF13086.6 PIK42632.1 - 3 7.5 14.6 8.7 6.0 0.0 5.3 5 1 0 5 5 4 0 AAA domain ApoLp-III PF07464.11 PIK42632.1 - 3.7 7.6 7.3 2.2 8.4 1.6 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Sigma70_r3 PF04539.16 PIK42633.1 - 0.053 13.6 1.4 0.14 12.2 1.4 1.7 1 0 0 1 1 1 0 Sigma-70 region 3 DUF2314 PF10077.9 PIK42635.1 - 0.16 12.0 1.3 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2314) YcbB PF08664.10 PIK42636.1 - 0.2 11.7 0.0 0.2 11.7 0.0 2.6 3 0 0 3 3 3 0 YcbB domain VWA PF00092.28 PIK42637.1 - 1.6e-07 31.8 0.3 3.8e-07 30.5 0.1 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK42637.1 - 4.6e-05 24.0 0.1 0.00011 22.8 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK42637.1 - 0.1 12.0 0.9 0.45 9.9 0.9 2.0 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein Takusan PF04822.13 PIK42637.1 - 8 6.4 10.2 0.09 12.7 0.8 2.6 3 0 0 3 3 3 0 Takusan RIBIOP_C PF04950.12 PIK42638.1 - 2.4e-89 299.6 0.0 1.3e-88 297.2 0.0 2.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 PIK42638.1 - 1.1e-32 111.9 0.0 5.9e-32 109.6 0.0 2.4 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 PIK42638.1 - 0.00017 21.2 0.0 0.00017 21.2 0.0 3.7 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 PIK42638.1 - 0.0015 18.8 0.0 0.0042 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK42638.1 - 0.0026 18.2 0.0 0.0068 16.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 PIK42638.1 - 0.011 15.9 0.2 0.076 13.1 0.2 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK42638.1 - 0.019 15.3 0.0 0.059 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 PIK42638.1 - 0.18 11.9 0.0 0.18 11.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain Antistasin PF02822.14 PIK42639.1 - 7.8e-91 298.2 166.9 1.3e-09 38.6 9.9 10.2 10 0 0 10 10 10 10 Antistasin family dsrm PF00035.26 PIK42641.1 - 5.4e-38 129.5 3.5 2.8e-13 50.4 0.0 5.0 4 1 0 4 4 4 4 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK42641.1 - 6e-07 29.6 0.2 0.033 14.4 0.0 4.0 3 1 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 F-box PF00646.33 PIK42642.1 - 1.1e-09 37.9 0.6 1.4e-08 34.4 0.6 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 PIK42642.1 - 3.9e-09 36.3 4.4 3.9e-09 36.3 4.4 1.8 2 0 0 2 2 2 1 F-box-like DNA_pol3_delt_C PF14840.6 PIK42642.1 - 0.041 14.2 1.1 0.63 10.4 0.7 2.1 1 1 1 2 2 2 0 Processivity clamp loader gamma complex DNA pol III C-term CD20 PF04103.15 PIK42643.1 - 0.0016 18.5 11.6 0.0034 17.5 8.5 2.3 2 1 0 2 2 2 1 CD20-like family TauE PF01925.19 PIK42643.1 - 0.062 12.9 8.9 0.036 13.7 6.0 1.5 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE PhoQ_Sensor PF08918.10 PIK42644.1 - 0.036 13.9 1.1 0.058 13.2 1.1 1.3 1 0 0 1 1 1 0 PhoQ Sensor DUF308 PF03729.13 PIK42644.1 - 0.07 13.5 13.9 0.17 12.2 13.9 1.7 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) CD20 PF04103.15 PIK42645.1 - 0.0002 21.5 17.4 0.00048 20.3 17.4 1.6 1 1 0 1 1 1 1 CD20-like family Polysacc_synt PF01943.17 PIK42645.1 - 0.003 17.0 3.9 0.0038 16.6 3.9 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF373 PF04123.13 PIK42645.1 - 0.019 14.4 1.8 0.024 14.1 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF308 PF03729.13 PIK42645.1 - 1 9.8 13.6 3.4 8.0 13.3 2.1 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) CD20 PF04103.15 PIK42646.1 - 3.7e-05 23.9 17.0 0.00012 22.2 16.8 1.8 1 1 0 1 1 1 1 CD20-like family DEAD PF00270.29 PIK42647.1 - 6.8e-36 123.7 0.1 2.3e-34 118.7 0.1 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK42647.1 - 3.1e-18 66.1 0.0 2.6e-17 63.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK42647.1 - 0.00047 20.2 0.3 0.01 15.8 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 PIK42647.1 - 0.0079 16.2 0.8 0.69 9.9 0.1 3.1 2 2 0 2 2 2 1 Flavivirus DEAD domain DBP10CT PF08147.12 PIK42648.1 - 3.5e-15 56.0 7.4 3.5e-15 56.0 7.4 3.0 3 0 0 3 3 3 1 DBP10CT (NUC160) domain Phtf-FEM1B_bdg PF12129.8 PIK42650.1 - 2.2e-51 173.7 0.6 2.9e-51 173.4 0.6 1.1 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor Neur_chan_memb PF02932.16 PIK42650.1 - 0.057 13.5 0.6 0.098 12.7 0.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3169 PF11368.8 PIK42650.1 - 2 7.9 5.8 0.75 9.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) 2-oxoacid_dh PF00198.23 PIK42651.1 - 1e-54 185.5 0.0 1.2e-54 185.3 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 PIK42651.1 - 8e-17 61.3 0.1 1.6e-16 60.3 0.1 1.6 1 0 0 1 1 1 1 e3 binding domain RRM_1 PF00076.22 PIK42652.1 - 3.2e-16 58.9 0.0 5.9e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK42652.1 - 4.7e-06 26.2 0.0 5.7e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3791 PF12668.7 PIK42652.1 - 0.034 14.2 0.1 1.6 8.8 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3791) 7tm_1 PF00001.21 PIK42653.1 - 2.3e-16 59.9 21.0 2.3e-16 59.9 21.0 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK42653.1 - 0.0017 18.2 17.7 0.0039 17.0 17.7 1.7 1 1 0 1 1 1 1 Olfactory receptor CYYR1 PF10873.8 PIK42653.1 - 5.4 7.5 6.1 2.6 8.5 0.3 2.5 3 0 0 3 3 3 0 Cysteine and tyrosine-rich protein 1 DUF4231 PF14015.6 PIK42653.1 - 5.8 7.4 12.1 0.55 10.7 1.6 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4231) HYR PF02494.16 PIK42654.1 - 4.5e-88 289.7 44.1 1.3e-20 73.5 5.6 7.1 7 0 0 7 7 7 7 HYR domain DUF5011 PF16403.5 PIK42654.1 - 0.82 9.8 5.4 56 4.0 0.1 5.2 6 0 0 6 6 6 0 Domain of unknown function (DUF5011) ILEI PF15711.5 PIK42655.1 - 2e-19 69.8 0.1 2.2e-19 69.7 0.1 1.0 1 0 0 1 1 1 1 Interleukin-like EMT inducer Ras PF00071.22 PIK42656.1 - 2.1e-62 209.5 1.8 2.6e-62 209.2 1.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK42656.1 - 1.1e-33 115.9 0.9 2.1e-33 115.1 0.9 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK42656.1 - 6.4e-15 55.0 0.3 8.6e-15 54.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK42656.1 - 3.9e-05 23.2 0.2 0.00031 20.2 0.0 1.9 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK42656.1 - 0.00013 22.1 0.1 0.00078 19.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK42656.1 - 0.00053 19.6 0.1 0.0016 18.0 0.1 1.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK42656.1 - 0.00067 19.1 0.3 0.00099 18.5 0.3 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 PIK42656.1 - 0.0011 18.5 0.0 0.89 9.1 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK42656.1 - 0.0026 17.7 0.1 0.67 9.8 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 PIK42656.1 - 0.0031 16.7 1.3 1.1 8.3 0.0 3.0 1 1 1 2 2 2 1 G-protein alpha subunit DUF3873 PF12989.7 PIK42656.1 - 0.025 14.9 0.1 0.05 14.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Septin PF00735.18 PIK42656.1 - 0.067 12.4 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Septin DUF2757 PF10955.8 PIK42656.1 - 0.11 12.7 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) DUF4787 PF16029.5 PIK42657.1 - 6e-10 39.1 1.5 8.8e-10 38.5 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4787) CDP-OH_P_transf PF01066.21 PIK42657.1 - 0.00027 21.6 0.0 0.00045 20.9 0.0 1.3 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase SMC_N PF02463.19 PIK42658.1 - 5.3e-50 169.9 61.5 1.7e-48 165.0 61.5 3.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK42658.1 - 1.1e-20 74.1 0.9 3e-20 72.7 0.9 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 PIK42658.1 - 1.5e-11 44.7 3.7 2.6e-05 24.2 0.6 2.9 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 PIK42658.1 - 9.6e-08 32.1 29.8 9.6e-08 32.1 29.8 4.7 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 PIK42658.1 - 4.8e-05 23.0 0.0 0.00015 21.4 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Diphthamide_syn PF01866.17 PIK42659.1 - 2.1e-102 342.7 0.3 3e-102 342.1 0.3 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Ribosomal_L10 PF00466.20 PIK42659.1 - 0.061 13.5 2.0 4.7 7.4 0.1 3.0 3 0 0 3 3 3 0 Ribosomal protein L10 DUF5578 PF17741.1 PIK42660.1 - 1.8e-90 303.0 6.1 2.5e-90 302.6 6.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5578) Arm PF00514.23 PIK42660.1 - 2.4e-06 27.4 0.1 0.027 14.5 0.0 3.7 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK42660.1 - 0.0001 22.6 0.3 0.006 16.9 0.0 3.0 2 1 1 3 3 3 1 HEAT repeats Drf_GBD PF06371.13 PIK42660.1 - 0.014 15.0 2.3 0.028 14.0 0.3 2.2 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain Arm_2 PF04826.13 PIK42660.1 - 0.035 13.6 0.1 0.3 10.5 0.1 2.3 1 1 0 1 1 1 0 Armadillo-like Sec20 PF03908.13 PIK42661.1 - 0.00016 21.5 1.4 0.00016 21.5 1.4 1.8 2 0 0 2 2 2 1 Sec20 HMMR_N PF15905.5 PIK42661.1 - 0.098 12.1 20.6 0.14 11.6 20.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF745 PF05335.13 PIK42661.1 - 0.91 9.2 11.0 1.4 8.6 11.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF724 PF05266.14 PIK42661.1 - 1.7 8.4 19.5 1.6 8.5 8.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ALMT PF11744.8 PIK42661.1 - 2.8 6.7 7.6 3.6 6.3 7.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter C1_1 PF00130.22 PIK42662.1 - 0.019 14.9 1.1 0.036 14.0 1.1 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.21 PIK42662.1 - 0.038 14.1 1.4 0.088 13.0 1.4 1.5 1 0 0 1 1 1 0 FYVE zinc finger Homeodomain PF00046.29 PIK42663.1 - 1.3e-21 76.1 4.6 1.9e-21 75.7 4.6 1.2 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 PIK42664.1 - 1.8e-21 75.7 4.6 2.6e-21 75.2 4.6 1.2 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 PIK42665.1 - 2e-10 40.3 0.5 2.4e-10 40.1 0.5 1.1 1 0 0 1 1 1 1 Homeodomain Fibrinogen_C PF00147.18 PIK42667.1 - 9.1e-30 104.1 1.9 1e-29 103.9 1.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DED PF01335.21 PIK42668.1 - 0.00077 19.7 0.2 0.0011 19.2 0.2 1.2 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 PIK42668.1 - 0.019 15.1 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 Death domain DUF2095 PF09868.9 PIK42668.1 - 0.067 13.2 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) Cucumopine_C PF18631.1 PIK42669.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.0 1 0 0 1 1 1 0 Cucumopine synthase C-terminal helical bundle domain TEX19 PF15553.6 PIK42670.1 - 0.096 12.6 1.1 0.14 12.1 1.1 1.2 1 0 0 1 1 1 0 Testis-expressed protein 19 Presenilin PF01080.17 PIK42670.1 - 0.56 8.9 2.7 0.69 8.6 2.7 1.0 1 0 0 1 1 1 0 Presenilin Helitron_like_N PF14214.6 PIK42671.1 - 2.2e-29 103.1 0.1 3.8e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus QIL1 PF15884.5 PIK42673.1 - 0.044 14.4 0.1 0.1 13.2 0.1 1.6 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 RVT_1 PF00078.27 PIK42674.1 - 5e-16 58.9 0.0 7.2e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PKD_2 PF16407.5 PIK42675.1 - 0.023 14.9 0.4 0.033 14.4 0.3 1.4 1 1 0 1 1 1 0 PKD-like family DUF3127 PF11325.8 PIK42675.1 - 0.05 13.8 0.3 0.25 11.6 0.0 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3127) DUF4371 PF14291.6 PIK42676.1 - 6.8e-29 101.2 0.7 1.1e-17 64.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4371) RVT_1 PF00078.27 PIK42677.1 - 3.5e-34 118.3 0.0 4.5e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK42678.1 - 7.1e-06 25.9 16.2 0.0015 18.5 0.2 4.2 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK42678.1 - 0.0061 16.4 9.2 0.24 11.3 3.8 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK42678.1 - 0.044 13.7 12.4 0.69 9.9 1.4 3.4 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42678.1 - 0.05 13.4 0.2 0.05 13.4 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK42678.1 - 0.19 11.5 10.2 0.052 13.3 0.8 3.2 2 1 1 3 3 3 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK42678.1 - 0.29 10.9 11.0 11 5.8 0.3 3.6 2 1 1 3 3 3 0 Zinc knuckle Peptidase_S66 PF02016.15 PIK42679.1 - 0.023 14.8 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain NACHT PF05729.12 PIK42680.1 - 1.2e-16 61.1 0.0 3.4e-16 59.6 0.0 1.8 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK42680.1 - 9.9e-07 28.7 2.8 0.0035 17.4 0.2 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK42680.1 - 2.1e-05 24.7 2.4 0.083 13.2 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK42680.1 - 5.2e-05 23.8 5.1 0.082 13.5 0.0 4.5 3 1 1 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK42680.1 - 0.0011 19.2 0.1 0.016 15.3 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK42680.1 - 0.0082 15.7 0.0 0.026 14.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK42680.1 - 0.012 15.9 0.0 0.04 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain I-set PF07679.16 PIK42680.1 - 0.099 12.7 2.9 3.3 7.8 0.0 3.5 4 0 0 4 4 4 0 Immunoglobulin I-set domain ig PF00047.25 PIK42680.1 - 0.24 11.6 3.1 2.2 8.5 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin domain V-set PF07686.17 PIK42681.1 - 0.00026 21.2 0.0 0.00034 20.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain PP_kinase_C_1 PF17941.1 PIK42682.1 - 0.04 13.5 0.1 0.068 12.7 0.1 1.3 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 Ig_2 PF13895.6 PIK42683.1 - 6.2e-05 23.3 0.2 0.06 13.7 0.1 2.8 2 2 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK42683.1 - 0.00025 21.6 1.5 0.085 13.5 0.0 3.2 2 1 1 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK42683.1 - 0.0025 18.0 0.0 0.0062 16.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK42683.1 - 0.0054 16.3 0.0 0.0087 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK42683.1 - 0.033 13.4 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK42683.1 - 0.05 14.0 0.0 0.083 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Il13Ra_Ig PF18001.1 PIK42683.1 - 0.061 13.4 0.2 0.14 12.3 0.2 1.6 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain NACHT PF05729.12 PIK42683.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RVT_1 PF00078.27 PIK42685.1 - 9.1e-14 51.5 0.0 1.1e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 PIK42686.1 - 0.036 14.4 0.1 0.079 13.3 0.1 1.6 1 0 0 1 1 1 0 PRANC domain CDC73_N PF16050.5 PIK42688.1 - 6.2e-120 400.0 9.7 8.3e-120 399.6 9.7 1.2 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 PIK42688.1 - 6.8e-26 90.8 0.6 5.2e-13 49.0 0.0 2.8 1 1 1 2 2 2 2 RNA pol II accessory factor, Cdc73 family, C-terminal DUF563 PF04577.14 PIK42689.1 - 8.8e-11 42.3 0.0 1.3e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) FtsL PF04999.13 PIK42689.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Cell division protein FtsL Peptidase_A17 PF05380.13 PIK42690.1 - 4.4e-54 182.8 0.0 6.8e-54 182.2 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK42690.1 - 2.4e-10 40.5 0.0 4.3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) NACHT PF05729.12 PIK42691.1 - 3e-12 46.8 0.0 3.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK42691.1 - 0.00017 21.3 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF3368 PF11848.8 PIK42691.1 - 0.0091 15.8 0.5 0.017 14.9 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3368) DAP3 PF10236.9 PIK42691.1 - 0.01 15.1 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK42691.1 - 0.017 15.4 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 PIK42691.1 - 0.089 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KDZ PF18758.1 PIK42692.1 - 3.1e-45 154.5 0.0 5.9e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase GTF2I PF02946.14 PIK42693.1 - 5e-12 45.7 0.0 9.6e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 GTF2I-like repeat HMG_box_2 PF09011.10 PIK42693.1 - 0.014 16.0 0.4 0.034 14.7 0.4 1.8 1 0 0 1 1 1 0 HMG-box domain DnaJ PF00226.31 PIK42698.1 - 6.9e-13 48.5 0.8 3.2e-12 46.4 0.0 2.5 3 0 0 3 3 3 1 DnaJ domain GYF_2 PF14237.6 PIK42698.1 - 1.7e-09 37.3 0.4 3.4e-06 26.7 0.1 2.7 2 0 0 2 2 2 2 GYF domain 2 DUF913 PF06025.12 PIK42698.1 - 0.0007 18.7 0.4 0.13 11.3 0.1 2.6 2 0 0 2 2 2 2 Domain of Unknown Function (DUF913) Arm PF00514.23 PIK42698.1 - 0.0017 18.3 0.4 5.8 7.1 0.0 5.3 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat zf-H2C2_2 PF13465.6 PIK42699.1 - 7.1e-14 51.5 8.5 1.9e-08 34.4 1.5 5.0 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK42699.1 - 1.1e-11 44.5 32.6 5.3e-06 26.6 1.0 4.4 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK42699.1 - 5.4e-08 33.0 26.5 0.00045 20.8 1.8 4.8 5 0 0 5 5 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK42699.1 - 0.0018 18.5 2.6 0.92 9.9 0.3 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK42699.1 - 0.024 15.0 5.7 0.7 10.4 0.8 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK42699.1 - 0.026 14.5 14.5 0.25 11.4 1.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 PIK42699.1 - 0.029 14.5 4.7 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 Aberrant zinc-finger zf-Di19 PF05605.12 PIK42699.1 - 0.11 12.8 0.5 0.042 14.2 2.9 4.6 3 1 3 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 PIK42699.1 - 0.11 12.3 0.4 0.72 9.7 0.2 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) FOXP-CC PF16159.5 PIK42699.1 - 0.16 12.6 19.9 4.3 8.0 0.2 5.1 4 1 1 5 5 5 0 FOXP coiled-coil domain zf-C2H2_3rep PF18868.1 PIK42699.1 - 0.4 11.4 7.8 1.7 9.4 1.3 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Elf1 PF05129.13 PIK42699.1 - 3.5 7.7 6.5 3.2 7.8 0.4 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zf-H2C2_5 PF13909.6 PIK42699.1 - 6.8 6.5 17.2 0.22 11.3 0.3 4.0 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-BED PF02892.15 PIK42699.1 - 7.9 6.6 14.4 19 5.4 2.0 3.9 1 1 2 3 3 3 0 BED zinc finger Sod_Fe_C PF02777.18 PIK42700.1 - 1.1e-35 121.8 0.1 2.1e-35 121.0 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 PIK42700.1 - 2.2e-18 66.5 0.3 5.4e-18 65.3 0.0 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain BEN PF10523.9 PIK42701.1 - 2.4e-07 30.9 0.1 6.2e-07 29.6 0.1 1.8 1 1 0 1 1 1 1 BEN domain MIP-T3 PF10243.9 PIK42701.1 - 0.043 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CH-like domain Transposase_21 PF02992.14 PIK42702.1 - 1.8e-05 24.1 0.2 4.7e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Transposase family tnp2 DUF4218 PF13960.6 PIK42702.1 - 0.00013 21.5 0.1 0.0021 17.6 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) TIR_2 PF13676.6 PIK42703.1 - 1.7e-08 35.1 0.0 2.1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 TIR domain HEAT_2 PF13646.6 PIK42704.1 - 4.1e-20 72.0 0.5 4.7e-10 39.7 0.2 2.2 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 PIK42704.1 - 1.5e-10 40.4 0.2 0.021 15.0 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 PIK42704.1 - 3.2e-07 30.7 1.6 0.005 17.3 0.1 3.7 3 1 0 3 3 3 2 HEAT-like repeat HEAT_PBS PF03130.16 PIK42704.1 - 2e-06 27.9 0.1 0.94 10.3 0.0 4.1 4 0 0 4 4 4 2 PBS lyase HEAT-like repeat Cnd1 PF12717.7 PIK42704.1 - 2.7e-05 24.3 0.8 0.00047 20.2 0.6 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK42704.1 - 0.018 13.6 0.5 0.026 13.1 0.5 1.4 1 1 0 1 1 1 0 Adaptin N terminal region Arm PF00514.23 PIK42704.1 - 0.035 14.2 0.5 22 5.2 0.0 3.4 2 1 1 3 3 3 0 Armadillo/beta-catenin-like repeat PC_rep PF01851.22 PIK42704.1 - 0.063 13.8 1.0 14 6.3 0.0 3.1 3 0 0 3 3 3 0 Proteasome/cyclosome repeat Cohesin_HEAT PF12765.7 PIK42704.1 - 0.16 12.3 2.0 2.4 8.6 0.1 3.1 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Myotub-related PF06602.14 PIK42706.1 - 1e-128 429.2 0.0 2.2e-128 428.1 0.0 1.5 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain FYVE PF01363.21 PIK42706.1 - 6.3e-18 64.7 9.9 2.1e-17 63.0 9.9 2.0 1 0 0 1 1 1 1 FYVE zinc finger DSPc PF00782.20 PIK42706.1 - 0.025 14.4 0.0 0.07 12.9 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK42706.1 - 0.026 14.1 0.0 0.066 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK42706.1 - 0.049 13.6 0.1 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family 7tm_1 PF00001.21 PIK42707.1 - 3.2e-42 144.7 0.3 4.3e-42 144.2 0.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK42707.1 - 4.8e-12 46.1 12.6 7.1e-12 45.5 12.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK42707.1 - 4.5e-09 36.1 12.8 6.2e-09 35.6 12.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK42707.1 - 0.17 11.6 8.8 0.25 11.1 8.8 1.3 1 0 0 1 1 1 0 Olfactory receptor DUF4834 PF16118.5 PIK42707.1 - 1.1 10.3 7.1 4.9 8.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) VKOR PF07884.14 PIK42708.1 - 4.3e-28 98.0 10.1 5.8e-28 97.6 10.1 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family SatRNA_48 PF17485.2 PIK42708.1 - 0.16 11.1 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Satellite RNA 48 kDa protein Aldo_ket_red PF00248.21 PIK42709.1 - 1.6e-50 172.0 0.0 2.2e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family RICTOR_M PF14666.6 PIK42709.1 - 0.16 11.7 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain BTB_2 PF02214.22 PIK42710.1 - 5.8e-20 71.5 0.0 9.5e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK42710.1 - 0.00071 19.8 0.1 0.0083 16.3 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain YqaJ PF09588.10 PIK42711.1 - 2.5e-14 53.7 0.0 4.7e-14 52.8 0.0 1.4 1 1 0 1 1 1 1 YqaJ-like viral recombinase domain Viral_alk_exo PF01771.17 PIK42711.1 - 1.9e-08 33.6 0.4 7.4e-08 31.7 0.0 1.8 2 0 0 2 2 2 1 Viral alkaline exonuclease zf-CCCH_7 PF18586.1 PIK42711.1 - 0.028 14.7 0.5 0.08 13.3 0.5 1.7 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Vma12 PF11712.8 PIK42712.1 - 2.2e-21 76.4 0.0 3.1e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF525 PF04379.14 PIK42713.1 - 3.9e-21 75.1 0.1 8e-21 74.1 0.1 1.5 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.11 PIK42713.1 - 4.4e-08 33.5 0.2 1.6e-07 31.8 0.0 2.0 2 1 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like 7tm_2 PF00002.24 PIK42714.1 - 8.1e-30 103.9 22.0 1.2e-29 103.3 22.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) ubiquitin PF00240.23 PIK42715.1 - 1.1e-05 25.1 0.1 0.02 14.6 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin family Ank_4 PF13637.6 PIK42715.1 - 1.5e-05 25.5 0.7 0.013 16.1 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK42715.1 - 0.00015 22.3 0.3 0.051 14.2 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK42715.1 - 0.0062 16.9 0.2 45 5.1 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeat Rogdi_lz PF10259.9 PIK42716.1 - 6.3e-27 94.7 0.1 1.3e-26 93.6 0.1 1.5 1 1 0 1 1 1 1 Rogdi leucine zipper containing protein SNF5 PF04855.12 PIK42717.1 - 2.1e-58 197.9 0.6 2.3e-30 106.1 0.0 2.0 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 EMG1 PF03587.14 PIK42718.1 - 1.9e-23 83.2 0.1 2e-23 83.0 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Ig_3 PF13927.6 PIK42720.1 - 1.9e-08 34.8 0.4 0.0058 17.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK42720.1 - 5.3e-06 26.4 0.3 0.035 14.2 0.0 2.8 1 1 2 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK42720.1 - 2e-05 24.7 0.3 0.062 13.5 0.0 3.0 1 1 2 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK42720.1 - 0.00061 20.1 1.1 0.11 12.8 0.6 2.7 2 2 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK42720.1 - 0.002 18.2 0.9 2.3 8.5 0.4 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK42720.1 - 0.062 13.4 0.3 0.14 12.2 0.3 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Microtub_bd PF16796.5 PIK42721.1 - 1.2e-08 35.0 1.1 1.8e-08 34.4 0.2 1.8 2 0 0 2 2 2 1 Microtubule binding Kinesin PF00225.23 PIK42721.1 - 4.4e-07 29.2 0.1 9e-07 28.1 0.1 1.6 1 1 0 1 1 1 1 Kinesin motor domain tRNA_m1G_MT PF01746.21 PIK42722.1 - 0.018 14.7 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase TetR_C_8 PF14278.6 PIK42722.1 - 0.11 12.7 0.2 4.6 7.4 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region FoP_duplication PF13865.6 PIK42723.1 - 0.5 11.0 6.7 6.8 7.3 0.2 2.3 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 AAA_12 PF13087.6 PIK42724.1 - 4.6e-26 91.7 0.0 7.4e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.10 PIK42725.1 - 1.3e-71 239.5 0.8 4.6e-71 237.7 0.5 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.6 PIK42725.1 - 8.3e-51 173.3 1.1 2.3e-29 103.0 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 PIK42725.1 - 2.4e-17 62.9 0.0 4.7e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_12 PF13087.6 PIK42725.1 - 5.3e-16 58.8 0.0 9.5e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK42725.1 - 3.9e-14 52.8 0.0 9.3e-13 48.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK42725.1 - 1.2e-10 41.9 0.0 7.7e-10 39.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 PIK42725.1 - 3.7e-06 27.0 0.0 6.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 PIK42725.1 - 0.0002 21.3 0.0 0.00094 19.1 0.0 2.1 2 0 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 PIK42725.1 - 0.00098 18.7 0.0 0.034 13.7 0.0 2.4 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 PIK42725.1 - 0.0022 17.3 0.0 0.0047 16.2 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK42725.1 - 0.0057 17.1 0.1 0.013 15.9 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 PIK42725.1 - 0.0077 15.9 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain NACHT PF05729.12 PIK42725.1 - 0.027 14.4 0.1 0.056 13.4 0.1 1.6 1 1 0 1 1 1 0 NACHT domain ATPase PF06745.13 PIK42725.1 - 0.031 13.6 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 KaiC PIF1 PF05970.14 PIK42725.1 - 0.037 13.2 0.0 3.9 6.5 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase VirE1 PF12189.8 PIK42725.1 - 0.068 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Single-strand DNA-binding protein AAA PF00004.29 PIK42725.1 - 0.076 13.4 0.2 0.15 12.5 0.2 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 PIK42725.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 PIK42725.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF269 PF03270.13 PIK42725.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF269 IMS PF00817.20 PIK42727.1 - 2.4e-33 115.3 0.2 9e-33 113.4 0.0 1.8 2 0 0 2 2 2 1 impB/mucB/samB family HEPN_Apea PF18739.1 PIK42727.1 - 0.063 13.7 0.5 0.12 12.8 0.5 1.5 1 0 0 1 1 1 0 Apea-like HEPN IMS_C PF11799.8 PIK42728.1 - 1.6e-17 64.3 0.3 3.1e-17 63.4 0.3 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 PIK42728.1 - 2.4e-05 24.4 0.0 5.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif IMS PF00817.20 PIK42728.1 - 6e-05 23.1 0.1 0.00015 21.7 0.0 1.8 2 0 0 2 2 2 1 impB/mucB/samB family RNF220 PF15926.5 PIK42728.1 - 0.017 14.7 3.3 0.02 14.5 1.9 1.9 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Vps36-NZF-N PF16988.5 PIK42728.1 - 0.089 12.2 0.1 0.24 10.8 0.1 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain ZZ PF00569.17 PIK42728.1 - 0.17 11.7 1.0 0.42 10.5 1.0 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF2181 PF10223.9 PIK42730.1 - 2.8e-40 138.3 0.0 3.5e-40 138.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) Mito_carr PF00153.27 PIK42731.1 - 9.8e-66 217.7 3.1 7.6e-25 86.7 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein VanW PF04294.13 PIK42731.1 - 0.09 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 VanW like protein FOG_N PF15888.5 PIK42731.1 - 0.21 11.9 0.7 0.67 10.3 0.1 2.0 3 0 0 3 3 3 0 Folded gastrulation N-terminus adh_short PF00106.25 PIK42732.1 - 3e-30 105.2 0.3 6e-18 65.0 0.0 2.8 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK42732.1 - 2.3e-20 73.1 0.0 5.6e-12 45.7 0.0 2.9 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK42732.1 - 2.9e-08 33.8 0.0 4.6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 PIK42732.1 - 0.004 17.1 0.2 0.0085 16.0 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TBP PF00352.21 PIK42732.1 - 0.008 16.1 1.6 2.6 8.0 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) Sacchrp_dh_NADP PF03435.18 PIK42732.1 - 0.012 15.9 0.1 0.02 15.2 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain LDcluster4 PF18306.1 PIK42732.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster4 family F420_oxidored PF03807.17 PIK42732.1 - 0.047 14.3 0.1 0.094 13.3 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 PIK42732.1 - 0.061 12.8 0.0 0.18 11.2 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TetR_C_23 PF17931.1 PIK42732.1 - 0.069 13.3 1.2 0.51 10.5 0.0 2.5 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GHMP_kinases_C PF08544.13 PIK42732.1 - 0.094 13.1 0.2 0.42 11.0 0.1 2.0 2 0 0 2 2 2 0 GHMP kinases C terminal DUF1515 PF07439.11 PIK42732.1 - 0.18 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Adaptin_N PF01602.20 PIK42733.1 - 3.9e-101 339.2 8.8 7.3e-101 338.3 8.8 1.4 1 1 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 PIK42733.1 - 3.3e-57 192.3 0.8 7.6e-57 191.1 0.8 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 PIK42733.1 - 1e-56 190.4 0.0 3.1e-56 188.8 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT PF02985.22 PIK42733.1 - 7.1e-08 32.1 1.7 0.3 11.5 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 PIK42733.1 - 1.4e-07 31.7 3.8 2.9e-05 24.2 0.1 3.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK42733.1 - 9e-07 29.2 0.2 0.42 11.0 0.0 5.4 4 3 2 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 PIK42733.1 - 7.2e-05 23.2 1.7 2.4 8.8 0.0 5.0 5 0 0 5 5 5 2 HEAT-like repeat MMS19_N PF14500.6 PIK42733.1 - 0.0047 16.5 0.5 0.022 14.3 0.0 2.3 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 PIK42733.1 - 0.03 14.4 0.0 25 5.1 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat SH3_9 PF14604.6 PIK42734.1 - 3.8e-11 42.7 0.1 8.4e-11 41.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.23 PIK42734.1 - 0.03 14.4 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) SH3_1 PF00018.28 PIK42734.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 SH3 domain CARD PF00619.21 PIK42735.1 - 4.9e-11 42.5 2.1 1.4e-05 25.1 0.1 3.8 3 0 0 3 3 3 2 Caspase recruitment domain CARD_2 PF16739.5 PIK42735.1 - 6e-05 23.0 4.3 0.1 12.6 0.2 3.3 3 0 0 3 3 3 2 Caspase recruitment domain Phage_CI_repr PF07022.13 PIK42735.1 - 0.048 13.7 0.3 0.45 10.6 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain partial_CstF PF15861.5 PIK42735.1 - 0.065 13.0 0.3 0.16 11.8 0.3 1.6 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain DUF1892 PF08987.10 PIK42735.1 - 0.13 12.4 2.7 7 6.9 1.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) DotA PF11388.8 PIK42735.1 - 0.16 12.2 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Phagosome trafficking protein DotA DED PF01335.21 PIK42736.1 - 1.3e-05 25.3 0.3 3.1e-05 24.2 0.1 1.7 2 0 0 2 2 2 1 Death effector domain Aldo_ket_red PF00248.21 PIK42737.1 - 7.9e-26 90.9 0.0 9.5e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_8 PF13855.6 PIK42738.1 - 2e-32 110.7 10.8 5.6e-12 45.2 1.2 3.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK42738.1 - 8.3e-13 48.3 3.0 0.00017 21.9 1.6 3.3 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK42738.1 - 7.5e-10 38.9 0.0 1.3e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK42738.1 - 1.9e-06 27.5 2.2 0.0097 15.4 0.3 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK42738.1 - 6.8e-05 22.9 3.2 1.7 9.5 0.2 5.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRRNT PF01462.18 PIK42738.1 - 0.12 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain zf-C3H1 PF10650.9 PIK42740.1 - 2.9e-06 26.9 4.7 6.4e-06 25.8 4.7 1.5 1 0 0 1 1 1 1 Putative zinc-finger domain TPR_14 PF13428.6 PIK42740.1 - 0.00038 21.0 0.1 0.62 11.0 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Chitin_synth_1 PF01644.17 PIK42740.1 - 0.068 13.2 1.5 1.8 8.5 0.0 2.8 2 0 0 2 2 2 0 Chitin synthase TED_complement PF07678.14 PIK42741.1 - 2.4e-88 296.2 0.0 5.4e-88 295.0 0.0 1.5 2 0 0 2 2 2 1 A-macroglobulin TED domain A2M PF00207.22 PIK42741.1 - 2.6e-27 94.5 0.1 5.8e-27 93.4 0.1 1.6 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 PIK42741.1 - 1.5e-16 60.8 1.6 3.2e-16 59.8 1.1 1.9 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain SVA PF05326.11 PIK42741.1 - 0.094 12.7 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 Seminal vesicle autoantigen (SVA) RVT_1 PF00078.27 PIK42742.1 - 4.7e-14 52.4 0.0 7.8e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CD20 PF04103.15 PIK42743.1 - 0.0011 19.1 2.3 0.0014 18.8 2.3 1.1 1 0 0 1 1 1 1 CD20-like family LIN37 PF15306.6 PIK42744.1 - 8e-20 71.6 0.2 8e-20 71.6 0.2 1.9 1 1 1 2 2 2 1 LIN37 adh_short PF00106.25 PIK42745.1 - 4.4e-42 143.8 0.1 5.8e-42 143.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK42745.1 - 1.3e-38 132.9 0.1 1.6e-38 132.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK42745.1 - 2.5e-06 27.5 1.5 8.3e-06 25.8 1.5 1.8 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 PIK42745.1 - 0.1 12.5 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain EGF_CA PF07645.15 PIK42746.1 - 7.7e-79 259.7 183.3 8.4e-11 41.9 5.4 12.8 13 1 0 13 13 13 11 Calcium-binding EGF domain cEGF PF12662.7 PIK42746.1 - 2e-38 129.9 79.2 1.4e-07 31.3 3.9 12.0 11 0 0 11 11 11 9 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK42746.1 - 4.6e-08 33.1 142.8 4.9e-05 23.4 7.4 13.3 12 2 0 12 12 12 9 EGF domain FXa_inhibition PF14670.6 PIK42746.1 - 3.1e-06 27.3 41.7 0.00017 21.8 11.7 13.8 10 4 3 13 13 13 6 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK42746.1 - 0.0002 21.6 18.6 0.00081 19.6 4.8 14.0 13 2 1 14 14 14 5 EGF-like domain SMC_N PF02463.19 PIK42747.1 - 1.2e-38 132.8 51.8 2.4e-34 118.7 1.0 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK42747.1 - 1.4e-10 41.5 1.2 9.3e-07 29.2 0.1 4.0 3 1 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 PIK42747.1 - 2.5e-08 34.1 15.9 3.1e-05 23.9 0.0 4.8 5 0 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 PIK42747.1 - 0.0035 17.1 15.7 0.0035 17.1 15.7 4.4 1 1 2 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 PIK42747.1 - 0.043 14.1 0.0 0.2 11.9 0.0 2.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Baculo_PEP_C PF04513.12 PIK42747.1 - 3.5 7.7 24.7 6.5 6.8 5.7 5.2 5 1 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mito_carr PF00153.27 PIK42748.1 - 1.3e-64 214.1 1.6 1.3e-21 76.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK42748.1 - 8.1e-05 21.9 1.9 0.82 8.8 0.1 3.5 2 1 1 3 3 3 3 Gammaproteobacterial serine protease RP853 PF17542.2 PIK42748.1 - 0.19 10.8 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized RP853 ComZ PF10815.8 PIK42749.1 - 1.5e-07 31.3 5.4 2.3 8.3 0.1 6.6 2 2 0 5 5 5 1 ComZ PRE_C2HC PF07530.11 PIK42749.1 - 4.8e-07 29.8 9.1 0.95 9.6 0.3 5.6 1 1 3 5 5 5 2 Associated with zinc fingers TAL_effector PF03377.13 PIK42749.1 - 0.00017 21.8 3.8 2.9e+02 1.9 0.0 9.2 12 0 0 12 12 12 0 TAL effector repeat Pox_A3L PF05288.11 PIK42749.1 - 0.00022 21.2 2.7 18 5.4 0.0 4.7 1 1 4 6 6 6 0 Poxvirus A3L Protein Multi_ubiq PF14452.6 PIK42749.1 - 0.00038 20.6 0.7 62 3.9 0.0 5.3 1 1 6 7 7 7 0 Multiubiquitin DUF1966 PF09260.11 PIK42749.1 - 0.00079 19.7 1.5 6.5 7.1 0.1 4.9 1 1 4 5 5 5 1 Domain of unknown function (DUF1966) Flagellin_N PF00669.20 PIK42749.1 - 0.0032 17.6 2.4 42 4.2 0.1 4.6 4 1 1 5 5 5 0 Bacterial flagellin N-terminal helical region Uricase PF01014.18 PIK42749.1 - 0.0089 16.3 0.0 2.6 8.3 0.0 3.0 1 1 0 1 1 1 1 Uricase Coq4 PF05019.13 PIK42749.1 - 0.025 13.9 3.2 22 4.3 0.1 3.6 1 1 4 5 5 5 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF3718 PF12514.8 PIK42749.1 - 0.028 14.6 0.0 1.1e+02 3.0 0.0 5.2 2 1 5 7 7 7 0 Protein of unknown function (DUF3718) TYW3 PF02676.14 PIK42749.1 - 0.072 12.4 2.0 44 3.3 0.1 3.9 1 1 1 3 3 3 0 Methyltransferase TYW3 Peptidase_U32_C PF16325.5 PIK42749.1 - 0.074 13.3 3.2 54 4.2 0.5 4.9 1 1 1 2 2 2 0 Peptidase family U32 C-terminal domain Cerato-platanin PF07249.12 PIK42749.1 - 0.18 12.0 1.9 32 4.7 0.2 3.2 1 1 2 3 3 3 0 Cerato-platanin ALF PF03752.13 PIK42749.1 - 1.3 9.0 5.6 43 4.2 0.0 5.4 7 2 0 7 7 7 0 Short repeats of unknown function HTH_OrfB_IS605 PF12323.8 PIK42749.1 - 2.5 7.6 13.1 1e+02 2.5 0.0 6.9 2 2 8 10 10 10 0 Helix-turn-helix domain Sortilin_C PF15901.5 PIK42750.1 - 5.6e-32 111.4 3.8 7.4e-32 111.0 3.8 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 PIK42751.1 - 1e-76 258.6 0.0 1.4e-76 258.1 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 PIK42751.1 - 0.00025 20.6 17.6 3.5 8.0 0.3 5.9 5 0 0 5 5 5 4 BNR/Asp-box repeat DUF5050 PF16472.5 PIK42751.1 - 0.034 13.4 0.1 0.059 12.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) F5_F8_type_C PF00754.25 PIK42751.1 - 0.045 13.9 2.5 0.24 11.5 1.2 2.8 2 1 1 3 3 3 0 F5/8 type C domain BNR_6 PF15899.5 PIK42751.1 - 0.066 13.3 0.6 0.066 13.3 0.6 3.4 4 0 0 4 4 4 0 BNR-Asp box repeat Pkinase_Tyr PF07714.17 PIK42752.1 - 3e-82 275.8 0.0 4.8e-82 275.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42752.1 - 1.1e-33 116.8 0.0 1.6e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 PIK42752.1 - 0.004 16.1 0.0 0.0053 15.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain TIG PF01833.24 PIK42753.1 - 1.7e-18 66.5 14.3 2.4e-06 27.5 0.8 4.7 3 1 0 3 3 3 3 IPT/TIG domain PSI PF01437.25 PIK42753.1 - 1.4e-05 25.5 16.3 3e-05 24.4 16.3 1.6 1 0 0 1 1 1 1 Plexin repeat Sema PF01403.19 PIK42753.1 - 0.0027 16.6 0.4 0.0043 15.9 0.0 1.5 2 0 0 2 2 2 1 Sema domain Syndecan PF01034.20 PIK42753.1 - 0.0039 17.1 0.0 0.0073 16.2 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain TMEM154 PF15102.6 PIK42753.1 - 0.036 14.0 0.3 0.064 13.2 0.3 1.3 1 0 0 1 1 1 0 TMEM154 protein family SH2 PF00017.24 PIK42753.1 - 0.16 12.1 0.0 0.49 10.5 0.0 1.8 1 0 0 1 1 1 0 SH2 domain QRPTase_C PF01729.19 PIK42754.1 - 0.0031 17.3 2.6 0.0031 17.3 1.3 1.7 1 1 1 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain DUF4407 PF14362.6 PIK42754.1 - 0.49 9.7 5.6 0.88 8.9 5.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_23 PF13476.6 PIK42754.1 - 1.2 9.6 12.0 2.2 8.8 12.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_pol_Rbc25 PF08292.12 PIK42755.1 - 1.6e-40 138.3 0.0 2.8e-40 137.5 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 PIK42755.1 - 5.3e-20 71.6 0.6 1.3e-19 70.3 0.1 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 BTB PF00651.31 PIK42756.1 - 4.6e-19 68.7 0.0 6.2e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK42757.1 - 4.8e-10 39.5 0.2 1.1e-09 38.3 0.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 PIK42757.1 - 7.7e-10 39.0 0.1 1.9e-08 34.5 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain MutL_C PF08676.11 PIK42758.1 - 2.6e-31 108.4 0.0 5.4e-31 107.3 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain Evr1_Alr PF04777.13 PIK42758.1 - 2.5e-29 101.7 1.6 9.4e-29 99.8 1.6 2.1 1 0 0 1 1 1 1 Erv1 / Alr family DNA_mis_repair PF01119.19 PIK42758.1 - 5.1e-23 81.0 0.0 1.2e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 PIK42758.1 - 8.7e-15 54.8 0.1 2.5e-14 53.2 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK42758.1 - 2.6e-06 27.9 0.1 8.9e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Galactosyl_T PF01762.21 PIK42759.1 - 5.7e-47 160.1 0.2 8.4e-47 159.5 0.2 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK42759.1 - 1.3e-07 31.3 0.2 2.6e-07 30.3 0.2 1.4 1 1 0 1 1 1 1 Fringe-like RAI16-like PF10257.9 PIK42762.1 - 6.6e-72 242.4 2.3 1e-71 241.7 2.3 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Alpha-amylase PF00128.24 PIK42763.1 - 0.00015 21.4 0.0 0.00021 20.9 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain VQ PF05678.14 PIK42763.1 - 0.13 11.8 0.2 0.23 11.0 0.2 1.5 1 0 0 1 1 1 0 VQ motif Alpha-amylase_C PF02806.18 PIK42764.1 - 5.4e-15 55.6 0.1 2.1e-14 53.7 0.1 2.1 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 PIK42764.1 - 1.4e-07 31.4 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase PF00128.24 PIK42765.1 - 6.7e-15 55.5 0.0 2.5e-14 53.6 0.0 1.8 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 PIK42765.1 - 9.8e-15 54.8 0.8 2.5e-14 53.5 0.1 2.1 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain DED PF01335.21 PIK42766.1 - 0.00043 20.5 1.4 0.00072 19.8 1.4 1.4 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 PIK42766.1 - 0.0029 17.7 0.2 0.0049 17.0 0.2 1.4 1 0 0 1 1 1 1 Death domain DUF5102 PF17104.5 PIK42766.1 - 4.8 7.1 8.4 0.24 11.4 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) Spore_III_AB PF09548.10 PIK42767.1 - 1.2 9.3 6.2 0.92 9.6 3.8 2.0 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF4218 PF13960.6 PIK42768.1 - 0.0046 16.6 0.0 0.009 15.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) ELL PF10390.9 PIK42768.1 - 0.051 13.1 0.2 0.079 12.5 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL Hairy_orange PF07527.13 PIK42769.1 - 0.0053 16.9 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 Hairy Orange ER PF01133.17 PIK42769.1 - 0.063 13.3 0.9 0.42 10.7 0.1 2.6 2 0 0 2 2 2 0 Enhancer of rudimentary OmpH PF03938.14 PIK42771.1 - 0.015 15.7 9.6 0.021 15.2 9.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Flu_NS2 PF00601.19 PIK42771.1 - 0.016 15.5 1.9 0.016 15.5 1.9 2.0 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) YsaB PF13983.6 PIK42771.1 - 0.061 13.6 0.5 0.13 12.6 0.0 1.8 2 0 0 2 2 2 0 YsaB-like lipoprotein DUF641 PF04859.12 PIK42771.1 - 0.69 10.3 9.1 0.4 11.0 6.9 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) TMPIT PF07851.13 PIK42771.1 - 1.2 8.3 4.6 1.8 7.8 4.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein ERG4_ERG24 PF01222.17 PIK42772.1 - 7.8e-19 67.7 1.2 9.4e-19 67.5 1.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF443 PF04276.12 PIK42772.1 - 0.14 12.0 5.8 0.24 11.2 5.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF443) DUF2721 PF11026.8 PIK42772.1 - 0.18 11.7 4.7 4.1 7.3 0.2 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF2721) PGG PF13962.6 PIK42772.1 - 0.93 9.3 5.3 0.075 12.8 0.9 1.4 2 0 0 2 2 2 0 Domain of unknown function COX7a PF02238.15 PIK42772.1 - 1.6 9.1 6.5 0.82 10.1 1.1 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII ABC2_membrane_3 PF12698.7 PIK42772.1 - 5.1 6.1 10.1 6.5 5.8 10.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Ninjurin PF04923.12 PIK42772.1 - 7.1 6.6 7.8 2.6 8.0 1.4 2.4 1 1 2 3 3 3 0 Ninjurin DUF2614 PF11023.8 PIK42772.1 - 7.8 6.6 8.9 0.69 10.0 3.3 1.8 2 0 0 2 2 2 0 Zinc-ribbon containing domain LBR_tudor PF09465.10 PIK42773.1 - 9e-14 51.0 0.1 1.6e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain Myb_DNA-bind_5 PF13873.6 PIK42773.1 - 3.6e-12 46.2 4.5 1.4e-11 44.3 3.3 2.5 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Tudor_3 PF18115.1 PIK42773.1 - 4e-05 23.4 0.0 8.5e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Myb_DNA-bind_4 PF13837.6 PIK42773.1 - 8.4e-05 22.9 0.4 0.00037 20.8 0.4 2.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF1325 PF07039.11 PIK42773.1 - 0.0015 18.6 0.0 0.0083 16.2 0.0 2.2 2 0 0 2 2 2 1 SGF29 tudor-like domain Corona_nucleoca PF00937.18 PIK42773.1 - 0.0045 16.1 11.5 0.0045 16.1 11.5 1.5 2 0 0 2 2 2 1 Coronavirus nucleocapsid protein 53-BP1_Tudor PF09038.10 PIK42773.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor Agenet PF05641.12 PIK42773.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Agenet domain SOBP PF15279.6 PIK42773.1 - 0.43 11.1 13.9 0.65 10.6 13.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein VASP_tetra PF08776.11 PIK42774.1 - 3.3e-15 55.4 5.7 4.6e-15 54.9 5.7 1.2 1 0 0 1 1 1 1 VASP tetramerisation domain WH1 PF00568.23 PIK42775.1 - 6.1e-31 106.6 0.2 7.1e-31 106.4 0.2 1.1 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.18 PIK42775.1 - 8.2e-05 22.9 0.1 0.00016 21.9 0.1 1.5 1 1 0 1 1 1 1 RanBP1 domain DCP1 PF06058.13 PIK42775.1 - 0.0048 16.8 0.1 0.007 16.3 0.1 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family AMIN PF11741.8 PIK42775.1 - 0.012 15.7 0.1 0.031 14.4 0.1 1.7 2 0 0 2 2 2 0 AMIN domain Kelch_1 PF01344.25 PIK42775.1 - 0.19 11.4 0.3 0.6 9.7 0.0 1.9 2 0 0 2 2 2 0 Kelch motif TRAPP PF04051.16 PIK42776.1 - 2.5e-34 118.1 0.0 2.8e-34 118.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component zf-CCHC PF00098.23 PIK42777.1 - 1.1e-05 25.3 0.9 0.00032 20.7 0.2 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42777.1 - 0.0065 16.3 0.2 0.011 15.6 0.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK42777.1 - 0.015 15.3 2.4 0.21 11.6 0.2 2.9 2 1 1 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK42777.1 - 0.25 11.1 9.2 0.33 10.7 0.0 3.1 2 1 1 3 3 3 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK42777.1 - 0.27 11.0 2.9 2.5 7.9 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK42778.1 - 3e-07 30.2 0.2 8.9e-06 25.4 0.2 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DEC-1_N PF04625.13 PIK42779.1 - 0.33 9.9 3.4 0.36 9.8 3.4 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Tail_spike_N PF18668.1 PIK42780.1 - 0.06 13.2 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain RVT_1 PF00078.27 PIK42781.1 - 3.8e-27 95.2 0.0 6.4e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK42781.1 - 1.3e-23 82.9 0.0 2.4e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42781.1 - 5.5e-14 52.3 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TrmB PF01978.19 PIK42781.1 - 0.17 11.8 0.0 0.63 10.0 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB zf-CCHC PF00098.23 PIK42782.1 - 1.5e-08 34.3 15.1 0.00026 20.9 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK42782.1 - 0.00051 19.8 10.6 0.21 11.5 6.2 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK42782.1 - 0.0011 18.9 14.7 0.073 13.1 0.9 3.6 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42782.1 - 0.0028 17.4 11.1 2 8.2 0.3 3.2 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK42782.1 - 0.0088 15.8 0.2 0.0088 15.8 0.2 3.6 4 0 0 4 4 4 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK42782.1 - 0.0089 15.7 0.8 0.0089 15.7 0.8 2.7 1 1 1 2 2 2 1 C2H2 zinc-finger DDE_Tnp_4 PF13359.6 PIK42784.1 - 2.9e-19 69.3 0.0 4.1e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK42784.1 - 8e-06 25.6 0.0 3.2e-05 23.6 0.0 1.7 1 1 1 2 2 2 1 Plant transposon protein zf-CCHC PF00098.23 PIK42786.1 - 0.0031 17.5 3.3 0.0031 17.5 3.3 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK42786.1 - 0.0048 16.6 7.4 0.46 10.3 1.1 2.5 1 1 1 2 2 2 2 Zinc knuckle DEC-1_N PF04625.13 PIK42786.1 - 1.6 7.7 4.8 2.3 7.1 4.8 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Gemini_AL1 PF00799.20 PIK42787.1 - 0.017 15.5 0.5 0.051 13.9 0.1 2.0 2 0 0 2 2 2 0 Geminivirus Rep catalytic domain ATPase_2 PF01637.18 PIK42787.1 - 0.065 13.1 0.0 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 PIK42787.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TMEM154 PF15102.6 PIK42788.1 - 0.011 15.7 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.8 PIK42788.1 - 0.04 13.8 0.4 0.23 11.4 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Glycophorin_A PF01102.18 PIK42788.1 - 0.11 12.7 1.5 0.12 12.6 0.1 1.7 2 0 0 2 2 2 0 Glycophorin A SKG6 PF08693.10 PIK42788.1 - 1.6 8.2 6.7 1.9 8.0 5.6 1.6 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Y_phosphatase PF00102.27 PIK42789.1 - 1.5e-20 73.8 0.7 1.7e-20 73.6 0.7 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase PF00102.27 PIK42791.1 - 2.2e-18 66.7 0.0 3.6e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Fibrinogen_C PF00147.18 PIK42792.1 - 2.1e-15 57.1 1.7 2.6e-15 56.9 1.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Beta-Casp PF10996.8 PIK42792.1 - 0.092 13.1 0.0 0.16 12.3 0.0 1.4 1 1 0 1 1 1 0 Beta-Casp domain Fibrinogen_C PF00147.18 PIK42793.1 - 9.3e-40 136.8 0.8 1.1e-39 136.5 0.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK42793.1 - 3e-06 27.4 9.3 3e-06 27.4 9.3 1.8 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK42794.1 - 8.9e-32 110.7 13.1 1.2e-31 110.3 13.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK42795.1 - 1.7e-31 109.8 1.1 2e-31 109.5 1.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK42795.1 - 0.043 14.0 6.1 0.043 14.0 6.1 2.0 2 0 0 2 2 2 0 EGF domain EGF_MSP1_1 PF12946.7 PIK42795.1 - 0.37 10.9 5.9 0.81 9.8 5.9 1.6 1 0 0 1 1 1 0 MSP1 EGF domain 1 Tme5_EGF_like PF09064.10 PIK42795.1 - 1.7 8.6 8.4 0.21 11.5 4.3 1.7 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Ig_3 PF13927.6 PIK42797.1 - 2.2e-08 34.6 3.8 0.0033 18.0 0.1 3.9 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK42797.1 - 8.6e-06 25.7 0.1 0.15 12.1 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK42797.1 - 5e-05 23.4 1.4 0.2 11.8 0.0 3.0 3 1 0 3 3 3 2 Immunoglobulin V-set domain DUF4489 PF14879.6 PIK42797.1 - 0.0002 21.5 1.3 0.00058 20.0 1.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4489) Ig_2 PF13895.6 PIK42797.1 - 0.0019 18.5 7.9 0.55 10.6 0.1 3.9 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK42797.1 - 0.047 13.9 0.0 10 6.4 0.0 3.2 2 0 0 2 2 2 0 Immunoglobulin domain TFIIA_gamma_N PF02268.16 PIK42797.1 - 0.13 12.3 0.1 0.82 9.7 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain Lipocalin_4 PF13648.6 PIK42797.1 - 0.28 12.2 3.1 0.33 11.9 0.5 2.5 2 0 0 2 2 2 0 Lipocalin-like domain C2-set_2 PF08205.12 PIK42797.1 - 0.34 11.0 4.6 2.1 8.5 0.7 2.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Pkinase_Tyr PF07714.17 PIK42798.1 - 7.4e-18 64.8 0.0 1e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42798.1 - 1e-09 38.2 0.1 1.4e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain preSET_CXC PF18264.1 PIK42799.1 - 0.13 12.7 10.1 0.25 11.8 10.1 1.5 1 0 0 1 1 1 0 CXC domain AZUL PF16558.5 PIK42799.1 - 0.21 11.9 4.0 0.28 11.5 2.1 2.1 2 0 0 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A RVT_1 PF00078.27 PIK42800.1 - 1.7e-05 24.4 0.0 2.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 PIK42801.1 - 1.9e-07 31.6 5.4 0.0092 16.6 0.1 4.5 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK42801.1 - 3.4e-06 27.3 4.7 0.001 19.4 0.1 4.4 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK42801.1 - 1.3e-05 25.2 0.0 0.015 15.4 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK42801.1 - 5.7e-05 23.2 0.2 0.25 11.5 0.0 3.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK42801.1 - 0.00069 19.6 5.0 0.0086 16.1 0.4 3.3 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain DUF4083 PF13314.6 PIK42801.1 - 0.00096 19.0 2.7 0.0035 17.2 2.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4083) ig PF00047.25 PIK42801.1 - 0.0011 19.1 0.1 11 6.3 0.0 4.4 3 0 0 3 3 3 1 Immunoglobulin domain C1-set PF07654.15 PIK42801.1 - 0.0044 17.4 7.3 0.0047 17.3 0.8 3.4 3 0 0 3 3 3 1 Immunoglobulin C1-set domain EphA2_TM PF14575.6 PIK42801.1 - 0.0084 17.0 0.4 0.0084 17.0 0.4 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 PIK42801.1 - 0.026 14.8 0.2 0.085 13.1 0.2 1.8 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SP_C-Propep PF08999.10 PIK42801.1 - 0.029 14.2 1.0 0.075 12.8 1.0 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide DUF3377 PF11857.8 PIK42801.1 - 0.047 13.6 8.0 0.019 14.9 3.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) Insulin_TMD PF17870.1 PIK42801.1 - 0.051 13.6 5.1 0.13 12.3 5.1 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Flp1_like PF16982.5 PIK42801.1 - 0.055 12.9 3.8 0.25 10.8 3.8 2.3 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain V-set PF07686.17 PIK42802.1 - 0.00058 20.0 0.0 0.0028 17.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Big_3_2 PF12245.8 PIK42802.1 - 0.073 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain B-block_TFIIIC PF04182.12 PIK42802.1 - 0.086 13.0 2.4 14 5.9 0.1 3.8 2 1 1 3 3 3 0 B-block binding subunit of TFIIIC DUF3377 PF11857.8 PIK42802.1 - 0.32 11.0 1.6 0.42 10.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Pkinase_Tyr PF07714.17 PIK42803.1 - 2.5e-35 122.0 0.0 5e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42803.1 - 1e-16 61.1 0.0 1.8e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ig PF00047.25 PIK42803.1 - 7.7e-11 42.0 0.4 5.6e-10 39.3 0.5 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK42803.1 - 3.8e-09 37.0 2.0 1.3e-06 28.9 1.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK42803.1 - 8e-06 25.8 0.0 0.00015 21.8 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42803.1 - 5.5e-05 23.4 1.1 0.0023 18.3 0.2 3.0 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK42803.1 - 0.0055 16.9 2.3 0.059 13.5 0.3 3.6 3 2 0 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK42803.1 - 0.04 14.0 0.0 0.14 12.3 0.0 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF2929 PF11151.8 PIK42803.1 - 0.67 10.3 2.3 0.79 10.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) Lep_receptor_Ig PF06328.11 PIK42803.1 - 1.4 8.9 10.7 1.9 8.5 0.1 4.0 4 1 0 4 4 4 0 Ig-like C2-type domain Pkinase_Tyr PF07714.17 PIK42804.1 - 1.1e-20 74.0 0.0 7.1e-20 71.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42804.1 - 1.3e-09 37.8 0.0 1.5e-08 34.4 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain DUF4770 PF15994.5 PIK42804.1 - 0.058 13.6 0.9 0.095 12.9 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) 7tm_1 PF00001.21 PIK42805.1 - 7e-78 261.6 17.0 8.6e-78 261.3 17.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK42805.1 - 8.7e-15 54.8 13.2 1.4e-14 54.1 13.2 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK42805.1 - 8.3e-05 22.3 17.1 8.3e-05 22.3 17.1 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Exo_endo_phos PF03372.23 PIK42807.1 - 8.8e-08 32.0 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Metallophos PF00149.28 PIK42808.1 - 9e-12 45.9 3.3 2.9e-11 44.2 3.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK42808.1 - 2.3e-08 34.4 0.2 0.00022 21.5 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain ParcG PF10274.9 PIK42809.1 - 9.6e-17 61.7 0.0 2.3e-09 37.6 0.0 2.3 1 1 1 2 2 2 2 Parkin co-regulated protein HEAT_EZ PF13513.6 PIK42809.1 - 0.092 13.3 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 HEAT-like repeat RA PF00788.23 PIK42810.1 - 7.1e-10 39.4 0.0 0.00014 22.4 0.0 2.8 1 1 1 2 2 2 2 Ras association (RalGDS/AF-6) domain C2 PF00168.30 PIK42810.1 - 1.5e-08 34.8 0.0 3.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain PI-PLC-Y PF00387.19 PIK42810.1 - 1.1e-05 25.8 1.9 1.4e-05 25.4 0.1 2.2 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain PI-PLC-X PF00388.19 PIK42811.1 - 0.0038 16.8 0.1 0.0073 15.9 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 PIK42811.1 - 0.017 15.5 0.3 0.07 13.5 0.3 2.1 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, Y domain TauD PF02668.16 PIK42812.1 - 2.4e-08 34.1 0.0 2.5e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 PIK42812.1 - 0.0022 17.2 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 CsiD GH97_N PF14508.6 PIK42812.1 - 0.029 13.9 0.1 0.037 13.5 0.1 1.0 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 N-terminal zf-TRAF PF02176.18 PIK42813.1 - 3.6e-15 56.4 8.2 7.8e-07 29.7 3.8 2.4 1 1 1 2 2 2 2 TRAF-type zinc finger zf-TRAF_2 PF15965.5 PIK42813.1 - 4.3e-05 23.9 6.8 0.095 13.2 0.1 3.0 2 1 1 3 3 3 2 TRAF-like zinc-finger Spectrin PF00435.21 PIK42813.1 - 0.027 14.9 6.4 0.029 14.9 0.2 2.5 1 1 1 2 2 2 0 Spectrin repeat BLOC1_2 PF10046.9 PIK42813.1 - 0.04 14.2 9.0 0.64 10.4 5.2 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4677 PF15726.5 PIK42813.1 - 0.063 13.4 0.1 9.4 6.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) KASH_CCD PF14662.6 PIK42813.1 - 0.063 13.1 5.6 0.12 12.1 5.6 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH COG5 PF10392.9 PIK42813.1 - 0.065 13.4 0.7 0.14 12.3 0.5 1.7 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Fib_alpha PF08702.10 PIK42813.1 - 0.065 13.4 4.9 0.15 12.3 4.9 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Sina PF03145.16 PIK42813.1 - 0.068 13.1 9.1 0.26 11.2 2.4 2.6 1 1 1 2 2 2 0 Seven in absentia protein family TRAF6_Z2 PF18048.1 PIK42813.1 - 0.11 12.6 2.2 1.9 8.7 0.0 3.2 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 Trimer_CC PF08954.11 PIK42813.1 - 0.13 11.9 0.2 0.13 11.9 0.2 3.6 3 2 2 5 5 5 0 Trimerisation motif zf-CCHC PF00098.23 PIK42813.1 - 0.13 12.4 1.3 20 5.5 0.1 2.8 2 0 0 2 2 2 0 Zinc knuckle Laminin_II PF06009.12 PIK42813.1 - 0.13 12.2 4.3 0.23 11.5 4.3 1.3 1 0 0 1 1 1 0 Laminin Domain II TSC22 PF01166.18 PIK42813.1 - 0.26 11.6 2.7 5.1 7.5 0.0 3.2 2 1 0 3 3 3 0 TSC-22/dip/bun family AATF-Che1 PF13339.6 PIK42813.1 - 0.29 11.8 4.4 0.53 11.0 4.4 1.4 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor MIF4G_like_2 PF09090.11 PIK42813.1 - 0.41 10.1 3.5 0.65 9.4 3.5 1.3 1 0 0 1 1 1 0 MIF4G like DUF1690 PF07956.11 PIK42813.1 - 0.76 10.2 9.9 0.14 12.6 0.5 2.4 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Allexi_40kDa PF05549.11 PIK42813.1 - 1.6 8.2 5.2 2.2 7.7 3.1 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein FlaC_arch PF05377.11 PIK42813.1 - 3.2 8.2 5.9 67 4.0 0.7 3.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 PIK42813.1 - 4.1 6.7 8.8 6.1 6.1 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 PIK42813.1 - 4.9 6.3 5.4 7.1 5.8 5.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein Spc7 PF08317.11 PIK42813.1 - 4.9 5.9 9.3 7.2 5.4 9.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF948 PF06103.11 PIK42813.1 - 5.4 7.3 10.6 4.7 7.5 6.0 2.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) COG6 PF06419.11 PIK42813.1 - 5.6 5.0 8.5 0.57 8.3 0.2 2.0 1 1 1 2 2 2 0 Conserved oligomeric complex COG6 DUF16 PF01519.16 PIK42813.1 - 5.8 7.5 8.7 50 4.5 8.4 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 PIK42813.1 - 5.9 6.9 7.6 9.1 6.3 5.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2428 PF10350.9 PIK42815.1 - 4.2e-47 160.7 5.9 1.1e-46 159.3 5.9 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 PIK42815.1 - 0.0092 16.2 0.9 1.5 9.3 0.0 4.8 4 1 1 5 5 5 1 HEAT repeat Peptidase_C65 PF10275.9 PIK42816.1 - 1.3e-80 270.4 0.2 1.6e-80 270.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 PIK42816.1 - 1.5e-05 25.4 0.1 0.00052 20.5 0.1 2.3 1 1 0 1 1 1 1 OTU-like cysteine protease Methyltransf_16 PF10294.9 PIK42817.1 - 2.9e-05 23.9 0.1 4.8e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase ACI44 PF15270.6 PIK42817.1 - 0.072 13.3 0.0 0.65 10.2 0.0 2.4 2 0 0 2 2 2 0 Metallo-carboxypeptidase inhibitor EF-hand_1 PF00036.32 PIK42818.1 - 2.5e-25 86.1 18.3 8.6e-07 28.1 0.1 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 PIK42818.1 - 2.2e-23 82.5 6.1 3.7e-13 49.7 0.8 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK42818.1 - 1.6e-21 74.3 7.6 4.1e-05 23.2 0.4 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK42818.1 - 2.9e-19 67.6 10.1 0.00012 21.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 PIK42818.1 - 1.3e-14 53.8 11.1 0.00092 19.0 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK42818.1 - 2.3e-07 31.1 0.3 0.0049 17.2 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK42818.1 - 1.5e-06 28.1 5.9 0.002 18.1 0.2 3.6 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 PIK42818.1 - 0.0055 17.0 0.2 0.14 12.5 0.0 2.5 2 1 1 3 3 3 1 EF-hand domain Caleosin PF05042.13 PIK42818.1 - 0.013 15.5 3.0 10 6.0 0.1 3.7 2 2 2 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.18 PIK42818.1 - 4.2 7.6 5.6 4.6 7.5 1.1 2.7 3 1 0 3 3 3 0 Dockerin type I domain APC1_C PF18122.1 PIK42819.1 - 3.9e-15 56.2 0.4 8.6e-15 55.1 0.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 PIK42819.1 - 7e-10 38.8 15.8 0.0011 19.3 0.1 6.5 6 0 0 6 6 6 4 Proteasome/cyclosome repeat ANAPC1 PF12859.7 PIK42819.1 - 1.2e-07 32.4 10.8 0.00023 21.7 0.0 3.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 1 DUF5600 PF18150.1 PIK42820.1 - 2.8e-43 146.8 0.5 5.5e-43 145.9 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 PIK42820.1 - 6.6e-17 61.4 0.3 2.8e-16 59.3 0.1 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 PIK42820.1 - 7.3e-05 22.9 0.0 0.00028 21.0 0.0 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 PIK42820.1 - 0.00014 21.9 0.0 0.00041 20.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 PIK42820.1 - 0.0003 20.1 0.0 0.0018 17.7 0.0 2.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK42820.1 - 0.013 15.4 0.4 0.23 11.5 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 PIK42820.1 - 0.015 15.7 0.2 0.17 12.3 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 PIK42820.1 - 0.046 13.2 0.1 0.046 13.2 0.1 2.3 2 0 0 2 2 2 0 EF hand GTP_EFTU PF00009.27 PIK42820.1 - 0.17 11.4 0.3 0.65 9.5 0.2 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Dynein_C PF18199.1 PIK42821.1 - 9.5e-95 317.3 0.0 5.1e-94 314.9 0.0 2.3 2 1 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 PIK42821.1 - 5.1e-91 304.6 0.0 1.1e-90 303.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK42821.1 - 7.5e-86 286.8 0.0 2.8e-84 281.6 0.1 2.7 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK42821.1 - 7.1e-53 178.8 0.0 1.4e-52 177.8 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 PIK42821.1 - 1.1e-46 159.5 5.8 2e-46 158.6 5.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 PIK42821.1 - 6.6e-43 145.6 0.0 9.1e-39 132.2 0.0 3.0 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 PIK42821.1 - 0.081 13.2 1.2 0.66 10.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain GAS PF13851.6 PIK42821.1 - 0.71 9.2 24.1 0.28 10.5 11.1 2.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding LUC7 PF03194.15 PIK42821.1 - 2.5 7.7 13.4 1.3 8.6 3.5 3.0 3 0 0 3 3 3 0 LUC7 N_terminus DUF148 PF02520.17 PIK42821.1 - 2.6 8.2 8.1 10 6.3 3.0 3.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF745 PF05335.13 PIK42821.1 - 7.2 6.3 13.3 13 5.5 2.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) 7tm_1 PF00001.21 PIK42823.1 - 1.9e-67 227.3 18.2 3.1e-67 226.7 18.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK42823.1 - 1.4e-08 34.5 22.4 2.2e-08 33.8 22.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK42823.1 - 8.6e-06 25.6 19.2 8.6e-06 25.6 19.2 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Sec62 PF03839.16 PIK42823.1 - 6.6 6.2 5.9 8.3 5.9 1.9 2.7 1 1 0 2 2 2 0 Translocation protein Sec62 Ank_2 PF12796.7 PIK42824.1 - 4.9e-16 59.1 0.0 4e-07 30.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK42824.1 - 2.1e-14 52.2 0.1 0.0017 18.6 0.0 6.0 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 PIK42824.1 - 3.6e-14 52.5 0.3 0.00039 20.8 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 PIK42824.1 - 9.7e-10 38.8 0.1 0.084 13.5 0.1 5.5 2 2 5 7 7 7 5 Ankyrin repeats (many copies) zf-MYND PF01753.18 PIK42824.1 - 1.2e-08 34.9 13.1 2.1e-08 34.1 13.1 1.4 1 0 0 1 1 1 1 MYND finger Ank_5 PF13857.6 PIK42824.1 - 5.8e-05 23.3 0.0 0.12 12.8 0.0 4.9 4 1 0 4 4 4 1 Ankyrin repeats (many copies) DUF2256 PF10013.9 PIK42824.1 - 0.43 10.7 5.6 0.79 9.9 5.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) MORN PF02493.20 PIK42825.1 - 2.4e-26 90.0 25.6 1.1e-05 25.1 1.6 6.5 6 0 0 6 6 6 6 MORN repeat Ank_2 PF12796.7 PIK42825.1 - 0.12 12.9 0.0 0.25 12.0 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) DUF4611 PF15387.6 PIK42825.1 - 8.1 6.7 11.4 0.59 10.4 5.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Glyco_transf_10 PF00852.19 PIK42826.1 - 7.4e-47 159.3 0.4 1.2e-46 158.6 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK42826.1 - 3.2e-08 34.0 0.1 6.8e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal ADH_zinc_N PF00107.26 PIK42827.1 - 3.3e-21 75.6 0.1 5.3e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK42827.1 - 6.7e-14 53.1 0.0 1.3e-13 52.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK42827.1 - 4.3e-12 45.9 0.0 9.3e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 PIK42827.1 - 0.011 15.0 0.3 0.019 14.3 0.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 PIK42827.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Sulfotransfer_1 PF00685.27 PIK42828.1 - 8.3e-12 45.1 0.0 1.2e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK42828.1 - 6.9e-08 33.1 0.0 9.1e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK42828.1 - 0.021 14.7 0.3 0.028 14.3 0.3 1.6 1 1 0 1 1 1 0 Sulfotransferase family SH2 PF00017.24 PIK42830.1 - 4.3e-13 49.2 0.1 1e-12 48.0 0.1 1.7 1 0 0 1 1 1 1 SH2 domain Death PF00531.22 PIK42830.1 - 0.12 12.5 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Death domain SH2 PF00017.24 PIK42831.1 - 2.2e-15 56.5 0.1 5.2e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 PIK42831.1 - 1.7e-06 27.6 0.7 0.00014 21.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK42831.1 - 0.071 12.7 0.1 8.9 6.0 0.0 3.5 2 1 0 2 2 2 0 SH3 domain Exo_endo_phos_2 PF14529.6 PIK42832.1 - 4.1e-13 49.2 0.2 1.7e-12 47.2 0.0 2.2 3 1 1 4 4 4 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK42832.1 - 0.00056 19.5 0.1 0.0016 18.0 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK42833.1 - 3.6e-42 144.4 0.2 9.5e-42 143.0 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RIC3 PF15361.6 PIK42833.1 - 0.038 14.4 0.1 0.094 13.1 0.1 1.7 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Toxin_36 PF10550.9 PIK42833.1 - 5.4 8.6 6.4 2.9 9.5 2.3 2.7 2 0 0 2 2 2 0 Conantokin-G mollusc-toxin ZU5 PF00791.20 PIK42834.1 - 1.1e-23 83.4 0.1 5.3e-12 45.9 0.0 3.1 2 0 0 2 2 2 2 ZU5 domain DED PF01335.21 PIK42834.1 - 1.9e-06 28.1 3.1 0.01 16.1 0.8 2.7 2 0 0 2 2 2 2 Death effector domain PqqD PF05402.12 PIK42834.1 - 0.12 12.7 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Golgin_A5 PF09787.9 PIK42835.1 - 0.017 14.6 19.3 0.029 13.8 19.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Atg14 PF10186.9 PIK42835.1 - 0.27 10.3 14.0 0.44 9.6 14.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Aldedh PF00171.22 PIK42836.1 - 1.3e-86 291.0 0.0 1.7e-86 290.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 PIK42837.1 - 4.1e-85 286.0 0.0 3.4e-60 203.9 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Isochorismatase PF00857.20 PIK42838.1 - 1.2e-30 107.0 0.0 2.9e-30 105.7 0.0 1.6 1 1 0 1 1 1 1 Isochorismatase family G6PD_C PF02781.16 PIK42839.1 - 2.4e-57 194.4 0.0 7.2e-51 173.1 0.0 2.3 2 0 0 2 2 2 2 Glucose-6-phosphate dehydrogenase, C-terminal domain Glucosamine_iso PF01182.20 PIK42839.1 - 7.2e-52 176.5 0.0 1e-51 176.0 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_N PF00479.22 PIK42839.1 - 4.8e-29 102.2 0.0 2.4e-28 100.0 0.0 2.1 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF4078 PF13300.6 PIK42840.1 - 6.2e-25 87.3 9.1 6.2e-25 87.3 9.1 3.6 3 1 0 3 3 3 1 Domain of unknown function (DUF4078) Poty_PP PF08440.10 PIK42840.1 - 0.14 11.2 1.6 0.11 11.5 0.2 1.5 2 0 0 2 2 2 0 Potyviridae polyprotein KfrA_N PF11740.8 PIK42840.1 - 0.18 12.5 0.4 0.18 12.5 0.4 4.2 4 1 0 4 4 4 0 Plasmid replication region DNA-binding N-term DivIC PF04977.15 PIK42840.1 - 2.4 8.0 10.6 0.21 11.4 0.6 2.9 2 0 0 2 2 2 0 Septum formation initiator THAP PF05485.12 PIK42841.1 - 1.9e-07 31.9 0.1 5.2e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 THAP domain AKAP2_C PF15304.6 PIK42841.1 - 0.062 12.6 0.7 0.081 12.2 0.7 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus DUF4614 PF15391.6 PIK42841.1 - 0.067 13.2 2.2 0.099 12.6 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Ras PF00071.22 PIK42842.1 - 1.4e-14 54.0 0.1 2.8e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK42842.1 - 9.8e-05 22.6 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RhoGAP-FF1 PF16512.5 PIK42842.1 - 0.00015 22.4 0.1 0.00052 20.6 0.1 1.9 1 0 0 1 1 1 1 p190-A and -B Rho GAPs FF domain NOG1 PF06858.14 PIK42842.1 - 0.00047 19.9 0.1 0.001 18.8 0.1 1.5 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) TPP_enzyme_M PF00205.22 PIK42842.1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain cobW PF02492.19 PIK42842.1 - 0.015 14.9 0.0 0.48 10.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 PIK42842.1 - 0.018 14.6 0.0 0.043 13.4 0.1 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK42842.1 - 0.064 13.3 0.0 0.7 10.0 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK42842.1 - 0.071 13.0 0.1 6 6.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 PIK42842.1 - 0.084 13.1 0.0 0.82 9.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 PIK42842.1 - 0.13 12.4 0.0 2.1 8.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain DUF5121 PF17165.4 PIK42842.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5121) FF PF01846.19 PIK42843.1 - 1.1e-05 25.5 0.2 0.25 11.5 0.0 2.7 2 0 0 2 2 2 2 FF domain OSK PF17182.4 PIK42845.1 - 2.8e-07 30.0 0.1 3.4e-07 29.7 0.1 1.1 1 0 0 1 1 1 1 OSK domain DUF4550 PF15084.6 PIK42845.1 - 0.078 13.4 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4550) rve_3 PF13683.6 PIK42846.1 - 2.2e-05 24.1 0.1 4.6e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 PIK42846.1 - 3.3e-05 24.1 0.1 9.5e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK42847.1 - 4e-28 97.4 0.0 1.1e-27 96.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42847.1 - 1.8e-24 86.0 0.0 5.3e-24 84.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK42847.1 - 2.6e-19 69.0 1.4 4.6e-19 68.3 1.4 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK42847.1 - 3.3e-06 27.3 0.0 8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK42847.1 - 0.00014 22.0 0.7 0.00036 20.7 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Gifsy-2 PF13856.6 PIK42847.1 - 0.11 12.8 0.0 0.44 10.9 0.0 2.0 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage DbpA PF03880.15 PIK42848.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 DbpA RNA binding domain RVT_1 PF00078.27 PIK42849.1 - 3.2e-38 131.4 0.0 4.8e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_5 PF13909.6 PIK42850.1 - 6.2e-11 41.9 7.0 2.8e-08 33.4 2.4 2.4 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-Di19 PF05605.12 PIK42850.1 - 0.00012 22.3 0.5 0.00012 22.3 0.5 1.7 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK42850.1 - 0.01 16.2 4.3 0.062 13.8 3.2 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK42850.1 - 0.68 10.9 3.9 11 7.2 0.6 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger NACHT PF05729.12 PIK42853.1 - 2.9e-11 43.6 0.1 4.9e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK42853.1 - 3.2e-10 40.2 0.4 0.00021 21.4 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42853.1 - 5.9e-08 33.2 0.9 0.068 13.8 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK42853.1 - 0.0015 18.5 1.0 0.0038 17.3 0.2 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain AAA_25 PF13481.6 PIK42853.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK42853.1 - 0.018 15.3 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ig PF00047.25 PIK42853.1 - 0.023 14.9 0.0 0.89 9.8 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin domain UL45 PF05473.12 PIK42853.1 - 0.029 14.0 0.2 0.11 12.2 0.3 1.8 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DAP3 PF10236.9 PIK42853.1 - 0.065 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Marek_A PF02124.15 PIK42854.1 - 0.004 17.0 1.2 0.0059 16.5 1.2 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A 7TM_GPCR_Str PF10326.9 PIK42854.1 - 0.037 13.4 0.1 0.048 13.0 0.1 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str DUF4446 PF14584.6 PIK42854.1 - 0.14 12.1 0.7 0.22 11.5 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) C2-set_2 PF08205.12 PIK42854.1 - 0.17 12.0 1.0 0.26 11.4 0.1 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain TMEM154 PF15102.6 PIK42854.1 - 0.23 11.4 1.6 0.34 10.8 1.6 1.4 1 1 0 1 1 1 0 TMEM154 protein family Phage_integrase PF00589.22 PIK42855.1 - 0.00011 22.1 0.1 0.036 13.8 0.0 2.4 1 1 1 2 2 2 2 Phage integrase family Integrase_1 PF12835.7 PIK42855.1 - 0.044 13.9 0.3 0.16 12.0 0.1 2.0 3 0 0 3 3 3 0 Integrase ARA70 PF12489.8 PIK42859.1 - 3.3e-08 33.8 10.4 4.2e-06 27.0 10.3 2.8 1 1 0 1 1 1 1 Nuclear coactivator DpnI_C PF17726.1 PIK42859.1 - 0.019 15.1 0.4 0.039 14.1 0.4 1.5 1 0 0 1 1 1 0 Dam-replacing HTH domain DUF1394 PF07159.12 PIK42859.1 - 0.091 12.0 1.1 0.13 11.5 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1394) DUF3873 PF12989.7 PIK42859.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) RE_NgoPII PF09521.10 PIK42859.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 NgoPII restriction endonuclease Nup54 PF13874.6 PIK42859.1 - 0.12 12.4 4.2 0.18 11.9 4.2 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 EPO_TPO PF00758.18 PIK42859.1 - 0.74 9.8 6.4 0.71 9.9 0.4 3.0 2 1 2 4 4 4 0 Erythropoietin/thrombopoietin ZapB PF06005.12 PIK42859.1 - 3.4 8.2 10.1 24 5.4 7.3 3.1 2 1 0 2 2 2 0 Cell division protein ZapB FA_desaturase PF00487.24 PIK42861.1 - 6.1e-16 59.0 21.1 6.1e-16 59.0 21.1 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Peptidase_A17 PF05380.13 PIK42862.1 - 2.8e-41 141.2 0.0 5.7e-41 140.2 0.0 1.5 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF5641 PF18701.1 PIK42862.1 - 1e-34 118.6 2.1 1e-34 118.6 2.1 2.6 3 0 0 3 3 3 1 Family of unknown function (DUF5641) rve PF00665.26 PIK42862.1 - 0.0061 16.7 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RAP1 PF07218.11 PIK42862.1 - 0.021 13.1 0.2 0.032 12.6 0.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RPN7 PF10602.9 PIK42862.1 - 0.095 12.4 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Phage_integrase PF00589.22 PIK42863.1 - 0.006 16.4 0.0 0.019 14.8 0.0 1.7 1 1 0 1 1 1 1 Phage integrase family RVT_3 PF13456.6 PIK42864.1 - 9.4e-06 25.4 0.2 1.2e-05 25.1 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH PF17917.1 PIK42864.1 - 0.00044 20.5 0.2 0.0058 16.9 0.2 2.2 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 PIK42864.1 - 0.03 14.5 0.4 0.063 13.5 0.4 1.5 1 1 0 1 1 1 0 RNase H RT_RNaseH_2 PF17919.1 PIK42864.1 - 0.047 13.7 0.3 0.54 10.3 0.3 2.3 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK42865.1 - 0.0057 16.2 0.0 0.0073 15.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2304 PF10066.9 PIK42867.1 - 0.11 12.8 3.5 0.17 12.2 3.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) TGF_beta PF00019.20 PIK42868.1 - 1e-29 103.6 0.6 2.4e-29 102.4 0.6 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain DUF3370 PF11850.8 PIK42869.1 - 0.014 14.3 0.0 0.019 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3370) Sulfotransfer_3 PF13469.6 PIK42870.1 - 0.0051 17.2 0.0 0.014 15.8 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family zf-Mss51 PF13824.6 PIK42870.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Sulfotransfer_1 PF00685.27 PIK42870.1 - 0.06 12.8 0.1 0.12 11.9 0.1 1.5 1 1 0 1 1 1 0 Sulfotransferase domain Ceramidase_alk PF04734.13 PIK42871.1 - 7.9e-34 117.2 0.1 1.1e-33 116.7 0.1 1.3 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal RVT_1 PF00078.27 PIK42871.1 - 4.3e-10 39.5 0.0 6.1e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Colicin PF01024.19 PIK42871.1 - 0.069 13.0 0.1 1.3 8.9 0.0 2.0 1 1 0 2 2 2 0 Colicin pore forming domain D_CNTX PF17492.2 PIK42871.1 - 0.26 11.5 3.7 0.47 10.7 3.7 1.4 1 0 0 1 1 1 0 Delta Ctenitoxins Ceramidase_alk PF04734.13 PIK42872.1 - 4.2e-223 741.6 0.9 5.1e-223 741.3 0.9 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 PIK42872.1 - 6.4e-51 172.6 0.1 1.1e-50 171.8 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Histone PF00125.24 PIK42873.1 - 1.4e-14 54.6 0.1 1.7e-14 54.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 PIK42873.1 - 1.5e-13 50.2 0.5 3e-13 49.3 0.5 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A RTP801_C PF07809.11 PIK42874.1 - 8e-31 106.4 0.1 1.1e-30 106.0 0.1 1.1 1 0 0 1 1 1 1 RTP801 C-terminal region RRM_1 PF00076.22 PIK42875.1 - 2.4e-16 59.3 0.3 5.4e-10 38.9 0.0 2.0 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK42875.1 - 0.00014 22.0 0.1 0.045 13.9 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK42875.1 - 0.036 14.1 0.1 6.6 6.8 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif NCBP3 PF10309.9 PIK42875.1 - 0.086 12.7 0.2 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 Nup35_RRM_2 PF14605.6 PIK42875.1 - 0.096 12.7 0.1 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif 7tm_2 PF00002.24 PIK42876.1 - 0.0016 17.7 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) PEN-2 PF10251.9 PIK42876.1 - 0.0078 16.6 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Sulfotransfer_2 PF03567.14 PIK42877.1 - 6.2e-14 52.5 0.9 1.5e-13 51.3 0.9 1.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK42877.1 - 0.00021 20.8 0.3 0.00065 19.3 0.3 1.7 1 1 0 1 1 1 1 Sulfotransferase domain 7tm_1 PF00001.21 PIK42878.1 - 0.00068 19.0 6.4 0.00088 18.7 6.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK42879.1 - 0.0021 17.4 11.2 0.0037 16.6 11.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RDD PF06271.12 PIK42879.1 - 0.025 14.8 3.9 0.025 14.8 3.9 2.5 2 1 0 2 2 2 0 RDD family FA_desaturase PF00487.24 PIK42879.1 - 3.2 7.5 14.1 44 3.8 14.1 2.1 1 1 0 1 1 1 0 Fatty acid desaturase Urate_ox_N PF06181.11 PIK42880.1 - 0.0042 16.5 4.5 0.006 16.0 4.5 1.3 1 0 0 1 1 1 1 Urate oxidase N-terminal Prominin PF05478.11 PIK42880.1 - 0.053 11.5 0.1 0.075 11.0 0.1 1.1 1 0 0 1 1 1 0 Prominin Peptidase_S10 PF00450.22 PIK42881.1 - 7.2e-96 322.1 2.1 9.4e-96 321.8 2.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase CDO_I PF05995.12 PIK42881.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Cysteine dioxygenase type I COesterase PF00135.28 PIK42883.1 - 1.5e-39 136.3 0.0 1.7e-39 136.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family ASH PF15780.5 PIK42884.1 - 5e-22 77.9 3.3 0.0086 16.3 0.0 11.8 12 1 0 12 12 12 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 PIK42884.1 - 2.4e-08 33.9 0.0 4.2 7.5 0.0 6.6 6 0 0 6 6 6 2 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 PIK42884.1 - 1.5e-07 31.6 0.0 0.25 11.6 0.0 5.2 6 0 0 6 6 6 3 Transmembrane protein 131-like PapD-like PF14874.6 PIK42884.1 - 2.6e-06 27.5 2.6 5.5 7.2 0.0 5.5 6 0 0 6 6 6 3 Flagellar-associated PapD-like Motile_Sperm PF00635.26 PIK42884.1 - 2.9e-06 27.1 0.6 34 4.3 0.0 7.2 8 0 0 8 8 8 1 MSP (Major sperm protein) domain AAA PF00004.29 PIK42885.1 - 1.1e-40 139.1 0.0 1.6e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 PIK42885.1 - 1.4e-07 31.4 0.0 2.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK42885.1 - 5.8e-07 29.9 0.2 0.0016 18.7 0.1 3.1 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 PIK42885.1 - 1e-06 28.8 0.5 2.6e-05 24.3 0.5 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 PIK42885.1 - 3.9e-06 26.6 0.0 7.9e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 PIK42885.1 - 1.2e-05 24.7 0.2 9.9e-05 21.7 0.0 2.0 1 1 1 2 2 2 1 TIP49 P-loop domain TniB PF05621.11 PIK42885.1 - 1.9e-05 24.1 0.1 0.17 11.2 0.0 3.1 2 1 1 3 3 3 2 Bacterial TniB protein AAA_2 PF07724.14 PIK42885.1 - 3.9e-05 23.8 0.0 6.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 PIK42885.1 - 8.2e-05 22.4 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 PIK42885.1 - 0.00031 21.2 0.4 0.011 16.1 0.2 2.6 1 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 PIK42885.1 - 0.0016 17.9 0.0 0.003 17.0 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 PIK42885.1 - 0.0025 17.9 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK42885.1 - 0.0037 17.2 0.0 0.023 14.6 0.0 2.2 1 1 0 1 1 1 1 NACHT domain Bac_DnaA PF00308.18 PIK42885.1 - 0.0045 16.9 0.0 0.0086 15.9 0.0 1.4 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_25 PF13481.6 PIK42885.1 - 0.0048 16.5 0.5 0.46 10.0 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 PIK42885.1 - 0.011 16.2 0.1 0.13 12.7 0.0 2.2 1 1 1 2 2 2 0 AAA domain DUF815 PF05673.13 PIK42885.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF4368 PF14287.6 PIK42885.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) Guanylate_kin PF00625.21 PIK42885.1 - 0.022 14.5 0.0 0.57 9.8 0.0 2.5 2 1 1 3 3 3 0 Guanylate kinase RNA_helicase PF00910.22 PIK42885.1 - 0.024 15.0 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 PIK42885.1 - 0.025 14.7 0.0 0.065 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 PIK42885.1 - 0.031 14.8 0.0 0.058 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK42885.1 - 0.04 13.9 0.0 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_10 PF12846.7 PIK42885.1 - 0.041 12.8 0.0 0.089 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain ATPase PF06745.13 PIK42885.1 - 0.042 13.2 0.2 5.3 6.3 0.0 2.4 1 1 1 2 2 2 0 KaiC AAA_24 PF13479.6 PIK42885.1 - 0.055 13.2 0.0 0.099 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK42885.1 - 0.072 13.6 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 PIK42885.1 - 0.14 11.2 0.0 0.27 10.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 PIK42885.1 - 0.16 11.6 0.1 0.97 9.1 0.1 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 PIK42885.1 - 0.17 11.4 0.1 0.48 9.9 0.0 1.9 2 1 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 PIK42885.1 - 0.17 10.9 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 p450 PF00067.22 PIK42886.1 - 7.6e-100 334.8 0.2 1.5e-99 333.9 0.2 1.4 1 1 0 1 1 1 1 Cytochrome P450 PsbT PF01405.17 PIK42886.1 - 0.25 11.2 0.7 0.57 10.0 0.7 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre T protein p450 PF00067.22 PIK42887.1 - 2.4e-95 320.0 0.8 4.4e-95 319.1 0.8 1.4 1 1 0 1 1 1 1 Cytochrome P450 NUDIX PF00293.28 PIK42888.1 - 5.3e-05 23.3 0.0 0.00021 21.4 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain Aha1_N PF09229.11 PIK42889.1 - 3.7e-38 130.8 4.5 8e-38 129.7 4.5 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 PIK42889.1 - 5e-26 91.4 2.2 3e-25 88.9 1.2 2.2 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein SVA PF05326.11 PIK42889.1 - 0.11 12.4 0.3 0.61 10.1 0.0 2.1 1 1 1 2 2 2 0 Seminal vesicle autoantigen (SVA) Spectrin PF00435.21 PIK42890.1 - 3.6e-87 287.8 278.6 3e-10 40.5 4.0 26.9 25 1 3 28 28 28 21 Spectrin repeat Syntaxin_2 PF14523.6 PIK42890.1 - 0.063 13.7 0.1 0.063 13.7 0.1 15.9 16 2 2 19 19 19 0 Syntaxin-like protein Tfb5 PF06331.12 PIK42890.1 - 0.86 9.6 6.3 8.2 6.5 1.3 4.6 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Zmiz1_N PF18028.1 PIK42890.1 - 0.95 9.8 9.3 5.6 7.3 0.4 5.7 5 0 0 5 5 5 0 Zmiz1 N-terminal tetratricopeptide repeat domain FlaG PF03646.15 PIK42891.1 - 0.095 12.9 0.0 0.22 11.7 0.0 1.5 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK42893.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK42895.1 - 0.07 13.3 0.1 0.17 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK42896.1 - 0.071 13.3 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK42897.1 - 0.074 13.2 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein Spectrin PF00435.21 PIK42899.1 - 1.3e-07 32.1 29.0 1e-06 29.2 1.3 4.5 3 1 0 4 4 4 3 Spectrin repeat LprI PF07007.12 PIK42899.1 - 0.51 11.0 7.7 0.82 10.4 3.7 2.8 2 0 0 2 2 2 0 Lysozyme inhibitor LprI Flagellin_N PF00669.20 PIK42899.1 - 1.5 8.9 7.5 11 6.1 0.9 3.2 3 0 0 3 3 3 0 Bacterial flagellin N-terminal helical region Cytochrom_B562 PF07361.11 PIK42899.1 - 1.8 9.3 15.9 0.43 11.3 3.3 3.9 3 2 0 3 3 3 0 Cytochrome b562 T3SSipB PF16535.5 PIK42899.1 - 4.2 7.8 21.7 1.7 9.1 6.2 3.3 3 0 0 3 3 3 0 Type III cell invasion protein SipB CSN5_C PF18323.1 PIK42899.1 - 7.7 7.5 13.9 3.3 8.7 2.0 3.2 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain Spectrin PF00435.21 PIK42900.1 - 1.4e-22 80.1 85.1 5.4e-09 36.5 2.2 10.9 7 2 2 11 11 11 8 Spectrin repeat Gp-FAR-1 PF05823.12 PIK42900.1 - 0.012 15.9 1.3 0.012 15.9 1.3 6.7 5 2 2 7 7 7 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ExoD PF06055.12 PIK42900.1 - 0.13 11.6 0.2 1.3 8.4 0.1 2.5 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD ATP-synt_DE PF00401.20 PIK42900.1 - 0.19 12.0 7.3 19 5.6 0.3 4.6 4 0 0 4 4 4 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF948 PF06103.11 PIK42900.1 - 0.72 10.1 40.3 9.1 6.6 0.1 10.7 8 2 0 9 9 9 0 Bacterial protein of unknown function (DUF948) DUF5611 PF18446.1 PIK42900.1 - 3.2 8.7 8.4 7.6 7.5 0.0 5.1 3 2 1 4 4 4 0 Domain of unknown function (DUF5611) FANCF PF11107.8 PIK42901.1 - 0.0087 15.3 0.2 0.012 14.9 0.2 1.2 1 0 0 1 1 1 1 Fanconi anemia group F protein (FANCF) PXT1 PF15214.6 PIK42901.1 - 0.058 13.8 0.1 0.27 11.6 0.1 2.0 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 RT_RNaseH_2 PF17919.1 PIK42902.1 - 6.7e-36 122.3 0.0 9.9e-36 121.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK42902.1 - 1.8e-30 105.3 0.0 2.4e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase UNC-93 PF05978.16 PIK42903.1 - 1.4e-11 44.4 10.9 1.4e-11 44.4 10.9 2.7 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 PIK42903.1 - 4.1e-06 25.9 36.3 0.0019 17.2 9.2 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK42905.1 - 7.3e-24 84.4 5.2 1e-23 83.9 5.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK42905.1 - 6.3e-23 81.3 16.3 6.3e-23 81.3 16.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily IncD PF17628.2 PIK42905.1 - 0.09 12.6 1.1 0.26 11.1 1.1 1.8 1 0 0 1 1 1 0 Inclusion membrane protein D 7tm_1 PF00001.21 PIK42906.1 - 2.9e-14 53.0 5.9 3.8e-14 52.7 5.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK42906.1 - 0.0025 17.2 5.9 0.0045 16.3 5.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK42906.1 - 0.097 12.0 9.6 0.9 8.9 3.8 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx PAN_1 PF00024.26 PIK42907.1 - 2.9e-10 39.9 12.1 3.2e-06 27.0 2.9 2.5 2 0 0 2 2 2 2 PAN domain SR-25 PF10500.9 PIK42907.1 - 6.4 6.3 7.5 11 5.6 7.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAN_1 PF00024.26 PIK42908.1 - 2.9e-10 40.0 11.6 3.8e-06 26.8 0.8 2.2 2 0 0 2 2 2 2 PAN domain Cript PF10235.9 PIK42908.1 - 1.3 9.6 8.1 4.6 7.9 3.5 2.3 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT DUF3614 PF12267.8 PIK42910.1 - 0.013 16.0 3.9 17 5.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3614) UPF0731 PF14982.6 PIK42910.1 - 0.066 13.4 9.2 14 6.0 0.2 3.7 4 0 0 4 4 4 0 UPF0731 family FtsK_gamma PF09397.10 PIK42910.1 - 0.077 12.8 0.0 89 3.0 0.0 3.1 3 0 0 3 3 3 0 Ftsk gamma domain Plasmo_rep PF12135.8 PIK42910.1 - 0.11 12.0 7.2 26 4.5 0.1 3.8 4 0 0 4 4 4 0 Plasmodium repeat family DNA_methylase PF00145.17 PIK42911.1 - 5e-23 82.0 0.6 1.5e-10 41.0 0.5 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase NACHT PF05729.12 PIK42912.1 - 5.6e-17 62.2 0.0 2.1e-16 60.3 0.0 2.0 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK42912.1 - 5.5e-09 36.2 1.7 0.0052 16.9 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42912.1 - 8.9e-06 26.2 9.6 0.51 11.0 0.1 5.4 4 1 1 5 5 5 2 Immunoglobulin domain ig PF00047.25 PIK42912.1 - 9.1e-06 25.8 1.9 0.72 10.1 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK42912.1 - 1.2e-05 25.3 2.0 0.018 15.1 0.3 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK42912.1 - 5.8e-05 23.3 6.1 0.096 13.0 0.0 4.9 4 1 1 5 5 5 2 Immunoglobulin domain DAG1 PF05454.11 PIK42912.1 - 0.0045 16.4 0.1 0.0081 15.6 0.1 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) AAA_25 PF13481.6 PIK42912.1 - 0.0074 15.9 0.1 0.02 14.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK42912.1 - 0.047 14.1 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain RVT_1 PF00078.27 PIK42913.1 - 5.1e-20 71.9 0.0 1.2e-18 67.4 0.0 2.3 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK42913.1 - 1.3e-05 25.1 0.1 2.3e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase EcoEI_R_C PF08463.10 PIK42913.1 - 0.014 15.5 0.1 0.028 14.5 0.1 1.5 1 0 0 1 1 1 0 EcoEI R protein C-terminal SNF2_assoc PF08455.10 PIK42913.1 - 0.062 12.3 0.1 0.1 11.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated Pkinase_Tyr PF07714.17 PIK42915.1 - 2.3e-26 92.6 0.5 3.3e-26 92.1 0.5 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42915.1 - 8.9e-18 64.6 0.5 1.3e-17 64.0 0.5 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK42915.1 - 2.9e-09 36.9 0.5 1.6e-08 34.5 0.3 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK42915.1 - 0.00033 21.2 0.4 0.00033 21.2 0.4 2.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK42915.1 - 0.0094 16.3 2.2 0.023 15.0 0.6 2.5 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK42915.1 - 0.3 11.3 2.5 0.6 10.3 0.3 2.6 3 1 0 3 3 3 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK42916.1 - 2e-08 34.2 0.8 0.00024 21.1 0.0 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK42916.1 - 5.7e-06 26.9 0.5 0.017 15.7 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Pentaxin PF00354.17 PIK42916.1 - 0.013 15.2 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Pentaxin family RVT_1 PF00078.27 PIK42917.1 - 2.6e-05 23.8 0.0 3.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ExbD PF02472.16 PIK42917.1 - 0.079 13.1 0.1 0.14 12.3 0.1 1.3 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF1857 PF08982.11 PIK42918.1 - 0.0038 17.1 0.1 0.0058 16.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) NACHT PF05729.12 PIK42919.1 - 3.2e-20 72.7 0.1 1.7e-19 70.4 0.0 2.1 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 PIK42919.1 - 0.00026 20.3 0.1 0.00061 19.1 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 PIK42919.1 - 0.00043 20.7 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 PIK42919.1 - 0.00051 19.7 0.0 0.0022 17.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK42919.1 - 0.0029 17.9 0.1 0.021 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK42919.1 - 0.0037 16.5 0.0 0.0061 15.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 PIK42919.1 - 0.0053 16.8 0.8 0.028 14.5 0.1 2.5 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 PIK42919.1 - 0.0058 16.0 0.0 0.018 14.4 0.0 1.8 1 0 0 1 1 1 1 KaiC AAA PF00004.29 PIK42919.1 - 0.013 15.9 0.0 0.064 13.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 PIK42919.1 - 0.022 14.5 0.0 0.065 13.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 PIK42919.1 - 0.045 14.3 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 PIK42919.1 - 0.12 12.9 0.7 0.66 10.5 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK42919.1 - 0.15 12.2 0.0 0.69 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK42921.1 - 1.3e-20 74.0 0.0 2.3e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK42921.1 - 2e-06 28.0 0.0 0.047 13.9 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK42921.1 - 2.9e-06 27.8 1.0 0.009 16.6 0.0 4.6 5 0 0 5 5 5 1 Immunoglobulin domain NB-ARC PF00931.22 PIK42921.1 - 0.00014 21.1 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain DUF1857 PF08982.11 PIK42921.1 - 0.00036 20.4 0.1 0.026 14.4 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1857) AAA_16 PF13191.6 PIK42921.1 - 0.0027 18.1 0.0 0.0049 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 PIK42921.1 - 0.0098 15.5 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain ig PF00047.25 PIK42921.1 - 0.013 15.6 0.3 2.1 8.6 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin domain ATPase PF06745.13 PIK42921.1 - 0.014 14.8 0.0 0.037 13.4 0.0 1.6 1 0 0 1 1 1 0 KaiC TniB PF05621.11 PIK42921.1 - 0.015 14.7 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 PIK42921.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 PIK42921.1 - 0.021 14.1 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 PIK42921.1 - 0.026 14.8 0.0 0.067 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 PIK42921.1 - 0.03 14.9 0.8 0.81 10.2 0.2 2.8 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 PIK42921.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK42921.1 - 0.07 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain C2-set_2 PF08205.12 PIK42922.1 - 2.2e-18 66.1 7.2 3.4e-10 39.8 0.8 3.6 2 1 1 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK42922.1 - 2.9e-10 40.6 11.3 1.1e-05 25.9 0.8 3.9 3 1 1 4 4 4 3 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK42922.1 - 2e-08 33.8 0.2 4.8e-08 32.6 0.1 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42922.1 - 9.6e-08 31.7 0.0 1.8e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK42922.1 - 5.9e-07 29.7 6.6 0.0016 18.8 1.1 4.3 1 1 3 4 4 4 2 Immunoglobulin domain C1-set PF07654.15 PIK42922.1 - 0.00021 21.6 1.8 0.053 13.9 0.1 4.0 3 1 1 4 4 4 1 Immunoglobulin C1-set domain I-set PF07679.16 PIK42922.1 - 0.00077 19.5 0.4 0.13 12.4 0.2 3.0 2 1 1 3 3 3 1 Immunoglobulin I-set domain ig PF00047.25 PIK42922.1 - 0.49 10.6 9.4 0.49 10.6 0.4 3.8 4 2 2 6 6 6 0 Immunoglobulin domain Asparaginase PF00710.20 PIK42923.1 - 8e-46 156.0 0.1 1.6e-45 155.0 0.0 1.5 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 PIK42923.1 - 4.4e-25 88.1 0.0 7.7e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Kinesin PF00225.23 PIK42924.1 - 2.7e-107 358.6 0.4 2.7e-107 358.6 0.4 3.0 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 PIK42924.1 - 2.9e-23 82.5 0.2 3.6e-22 78.9 0.0 3.0 3 0 0 3 3 3 1 Microtubule binding V_ATPase_I PF01496.19 PIK42925.1 - 2.5e-05 22.4 0.9 3.1e-05 22.1 0.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family NHL PF01436.21 PIK42925.1 - 0.015 15.4 0.0 16 5.8 0.0 4.0 4 0 0 4 4 4 0 NHL repeat TBCC_N PF16752.5 PIK42925.1 - 0.073 13.5 0.9 0.18 12.3 0.9 1.8 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Sipho_Gp157 PF05565.11 PIK42926.1 - 0.0016 18.5 1.2 0.0032 17.5 1.2 1.5 1 0 0 1 1 1 1 Siphovirus Gp157 TSC22 PF01166.18 PIK42926.1 - 0.0043 17.3 0.3 0.054 13.8 0.3 2.6 1 1 1 2 2 2 1 TSC-22/dip/bun family MIS13 PF08202.11 PIK42926.1 - 0.0053 16.1 4.3 0.0086 15.4 4.3 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF4140 PF13600.6 PIK42926.1 - 0.0098 16.3 3.6 0.2 12.1 1.2 2.4 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.12 PIK42926.1 - 0.033 14.2 7.2 0.03 14.4 4.8 2.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 PIK42926.1 - 0.044 13.3 3.0 0.087 12.4 3.0 1.6 1 0 0 1 1 1 0 fzo-like conserved region DivIC PF04977.15 PIK42926.1 - 0.048 13.4 2.0 0.19 11.5 2.0 2.1 1 0 0 1 1 1 0 Septum formation initiator RPW8 PF05659.11 PIK42926.1 - 0.066 12.9 1.1 0.15 11.7 1.1 1.6 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 bZIP_1 PF00170.21 PIK42926.1 - 0.07 13.2 1.1 0.07 13.2 1.1 2.9 3 1 1 4 4 3 0 bZIP transcription factor Hrs_helical PF12210.8 PIK42926.1 - 0.12 12.9 4.9 4.4 7.9 0.6 3.2 3 2 1 4 4 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate CENP-F_leu_zip PF10473.9 PIK42926.1 - 0.16 12.0 10.4 0.16 12.0 7.6 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MbeD_MobD PF04899.12 PIK42926.1 - 0.16 12.1 2.6 0.17 12.0 0.7 2.1 2 0 0 2 2 1 0 MbeD/MobD like ATG16 PF08614.11 PIK42926.1 - 0.26 11.5 8.0 0.067 13.4 4.8 1.6 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) YabA PF06156.13 PIK42926.1 - 0.27 11.9 5.3 0.18 12.5 2.6 2.1 2 0 0 2 2 2 0 Initiation control protein YabA Snapin_Pallidin PF14712.6 PIK42926.1 - 0.33 11.4 10.1 0.086 13.3 2.0 3.0 2 1 1 3 3 3 0 Snapin/Pallidin ZapB PF06005.12 PIK42926.1 - 0.33 11.4 10.5 0.11 13.0 5.1 2.8 2 2 1 3 3 3 0 Cell division protein ZapB HALZ PF02183.18 PIK42926.1 - 0.42 10.9 6.5 1 9.7 0.7 3.5 2 1 1 3 3 3 0 Homeobox associated leucine zipper Prominin PF05478.11 PIK42926.1 - 0.57 8.1 5.3 0.77 7.6 5.3 1.1 1 0 0 1 1 1 0 Prominin Cortex-I_coil PF09304.10 PIK42926.1 - 0.58 10.4 7.4 0.7 10.1 6.1 1.8 1 1 0 1 1 1 0 Cortexillin I, coiled coil BLOC1_2 PF10046.9 PIK42926.1 - 0.58 10.5 5.8 0.12 12.6 1.8 1.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4047 PF13256.6 PIK42926.1 - 0.65 10.2 5.4 0.14 12.4 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) SlyX PF04102.12 PIK42926.1 - 0.78 10.4 3.2 1.1 9.9 1.9 2.0 1 1 0 1 1 1 0 SlyX Lectin_N PF03954.14 PIK42926.1 - 0.92 9.3 8.3 0.43 10.3 5.3 1.9 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain NRBF2 PF08961.10 PIK42926.1 - 1.2 8.7 5.5 2.6 7.6 5.1 1.8 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Syntaxin-6_N PF09177.11 PIK42926.1 - 1.4 9.5 6.5 0.6 10.7 3.5 2.0 2 0 0 2 2 1 0 Syntaxin 6, N-terminal DUF4200 PF13863.6 PIK42926.1 - 1.5 9.2 9.9 12 6.4 5.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 PIK42926.1 - 1.9 8.7 12.1 0.47 10.7 7.0 2.2 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 PIK42926.1 - 4.9 7.4 8.7 1.6 9.0 1.5 3.2 2 2 1 3 3 3 0 JNK-interacting protein leucine zipper II HAUS6_N PF14661.6 PIK42926.1 - 8.1 6.0 9.8 0.83 9.2 5.2 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Ig_2 PF13895.6 PIK42929.1 - 2.1e-09 37.6 1.7 5.8e-07 29.8 0.5 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK42929.1 - 4.3e-08 33.6 3.9 0.0017 18.9 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK42929.1 - 2.8e-07 30.7 0.7 6.6e-06 26.3 0.0 2.6 2 1 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK42929.1 - 5.6e-07 29.5 0.2 0.003 17.6 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK42929.1 - 1.6e-05 25.0 0.5 0.2 11.8 0.0 3.3 3 1 1 4 4 4 2 Immunoglobulin domain Mcl1_mid PF12341.8 PIK42929.1 - 0.0098 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region Ig_3 PF13927.6 PIK42930.1 - 2.5e-07 31.2 4.6 0.0034 17.9 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK42930.1 - 1.8e-06 28.2 1.9 0.00081 19.7 0.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK42930.1 - 8.6e-06 25.9 1.5 0.00012 22.2 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK42930.1 - 6.3e-05 23.0 0.5 0.0036 17.3 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK42930.1 - 0.00024 21.2 4.4 0.007 16.5 0.2 3.3 2 1 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.6 PIK42930.1 - 0.034 14.1 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family TMEM51 PF15345.6 PIK42930.1 - 0.049 13.5 0.1 0.084 12.7 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 PRIMA1 PF16101.5 PIK42930.1 - 0.088 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Sel1 PF08238.12 PIK42931.1 - 1.4e-22 79.6 43.2 6.3e-05 23.5 1.4 10.2 10 0 0 10 10 10 6 Sel1 repeat TPR_17 PF13431.6 PIK42931.1 - 0.0017 18.6 0.6 0.31 11.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat Laminin_G_3 PF13385.6 PIK42931.1 - 0.043 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily TPR_14 PF13428.6 PIK42931.1 - 4.7 8.3 5.9 10 7.2 0.0 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK42931.1 - 7.3 7.2 11.3 6.9 7.3 0.2 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 PIK42932.1 - 2.1e-43 148.5 0.0 2.9e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42932.1 - 6e-17 61.9 0.0 1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK42932.1 - 0.0016 18.4 0.2 0.0036 17.3 0.2 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Rax2 PF12768.7 PIK42932.1 - 0.0058 16.1 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity TMEM154 PF15102.6 PIK42932.1 - 0.021 14.7 0.2 0.035 14.0 0.2 1.3 1 0 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 PIK42932.1 - 0.052 13.9 0.1 0.094 13.0 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) CD34_antigen PF06365.12 PIK42932.1 - 0.094 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family C1-set PF07654.15 PIK42932.1 - 0.11 12.9 2.6 0.18 12.2 0.6 2.2 2 0 0 2 2 2 0 Immunoglobulin C1-set domain zf-C2H2_jaz PF12171.8 PIK42933.1 - 5.9e-06 26.4 8.2 0.096 13.0 0.1 4.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zinc_ribbon_10 PF10058.9 PIK42933.1 - 0.014 15.1 1.5 0.014 15.1 1.5 2.6 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein PHD_2 PF13831.6 PIK42933.1 - 0.018 14.6 2.2 0.018 14.6 2.2 2.7 3 0 0 3 3 3 0 PHD-finger zf_C2H2_ZHX PF18387.1 PIK42933.1 - 0.025 14.2 12.9 0.048 13.3 0.2 3.7 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF629 PF04780.12 PIK42933.1 - 0.058 11.9 5.2 2.9 6.3 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF629) Not1 PF04054.15 PIK42933.1 - 0.11 11.4 0.2 0.27 10.1 0.2 1.6 1 1 0 1 1 1 0 CCR4-Not complex component, Not1 zf-C2H2_4 PF13894.6 PIK42933.1 - 0.64 11.0 25.8 0.17 12.8 1.1 5.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK42933.1 - 1.8 9.1 22.8 0.19 12.3 0.7 4.9 4 1 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK42933.1 - 2.9 8.5 18.6 0.97 10.0 1.0 6.0 5 1 0 5 5 5 0 Zinc-finger double domain zf-RING_6 PF14835.6 PIK42934.1 - 0.055 13.4 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C2H2_jaz PF12171.8 PIK42936.1 - 1.2e-05 25.5 11.0 0.27 11.6 0.1 5.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK42936.1 - 0.0073 17.1 21.5 0.18 12.7 1.2 5.9 5 0 0 5 5 5 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 PIK42936.1 - 0.11 12.2 0.2 0.11 12.2 0.2 4.5 4 1 1 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF629 PF04780.12 PIK42936.1 - 0.12 10.9 6.2 1.6 7.1 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 PIK42936.1 - 0.63 10.6 27.4 0.18 12.3 0.7 5.7 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-met PF12874.7 PIK42936.1 - 1.4 9.4 17.8 14 6.2 0.0 5.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK42937.1 - 8.2e-05 22.8 7.7 0.5 10.7 0.1 4.6 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 PIK42937.1 - 0.38 10.4 11.1 0.28 10.8 0.2 3.6 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_10 PF10058.9 PIK42937.1 - 0.98 9.2 7.7 0.09 12.5 1.6 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein PHD_2 PF13831.6 PIK42937.1 - 1.8 8.2 9.2 0.097 12.2 2.2 2.6 2 0 0 2 2 2 0 PHD-finger DUF629 PF04780.12 PIK42937.1 - 1.9 6.9 5.0 18 3.7 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 PIK42937.1 - 2.5 9.2 21.6 0.93 10.5 1.1 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.7 PIK42937.1 - 5.4 7.6 11.0 1.2e+02 3.2 0.1 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type NACHT PF05729.12 PIK42938.1 - 2.9e-10 40.3 0.1 4.7e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK42938.1 - 0.00011 21.5 2.7 0.00033 19.9 0.1 2.6 3 1 0 3 3 3 1 NB-ARC domain ABC_tran PF00005.27 PIK42938.1 - 0.0006 20.3 0.9 0.0006 20.3 0.9 2.3 2 2 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 PIK42938.1 - 0.0027 18.0 0.0 0.0063 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK42938.1 - 0.0032 17.9 0.0 0.0087 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK42938.1 - 0.01 16.2 0.1 0.017 15.5 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 PIK42938.1 - 0.02 14.3 0.3 0.053 12.9 0.0 1.9 2 1 0 2 2 2 0 Bacterial TniB protein AAA_29 PF13555.6 PIK42938.1 - 0.026 14.3 0.0 0.074 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 PIK42938.1 - 0.035 14.3 0.0 0.12 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 PIK42938.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 PIK42938.1 - 0.056 13.3 0.0 0.15 11.9 0.0 1.7 1 1 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 PIK42938.1 - 0.076 13.4 0.1 0.28 11.6 0.1 2.3 1 1 0 1 1 1 0 RNA helicase NACHT PF05729.12 PIK42939.1 - 3.1e-10 40.2 0.1 6.8e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK42939.1 - 1.9e-05 24.8 0.4 7.3e-05 22.9 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain AAA_16 PF13191.6 PIK42939.1 - 5e-05 23.8 0.0 9.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 PIK42939.1 - 0.0024 18.4 1.5 0.0071 16.9 1.4 2.0 1 1 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 PIK42939.1 - 0.0035 16.6 1.3 0.091 11.9 1.3 2.4 1 1 0 1 1 1 1 NB-ARC domain C1-set PF07654.15 PIK42939.1 - 0.01 16.2 0.4 0.039 14.3 0.4 2.0 1 0 0 1 1 1 0 Immunoglobulin C1-set domain DUF815 PF05673.13 PIK42939.1 - 0.017 14.3 0.0 0.049 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 PIK42939.1 - 0.025 14.1 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 PIK42939.1 - 0.047 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK42939.1 - 0.048 13.9 0.1 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 PIK42941.1 - 0.0021 18.1 0.3 0.0021 18.1 0.3 4.3 5 1 0 5 5 5 1 Dynamin family MMR_HSR1 PF01926.23 PIK42941.1 - 0.0052 16.8 0.1 0.027 14.6 0.1 2.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RPW8 PF05659.11 PIK42941.1 - 0.055 13.2 3.3 0.8 9.4 0.2 3.4 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Ig_3 PF13927.6 PIK42942.1 - 6.6e-05 23.4 0.1 0.0003 21.3 0.1 2.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK42942.1 - 0.00061 19.9 0.0 0.0029 17.7 0.0 2.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK42942.1 - 0.0029 17.8 0.0 0.0091 16.2 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK42942.1 - 0.0034 17.7 0.1 0.017 15.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain DUF5050 PF16472.5 PIK42942.1 - 0.0069 15.7 0.1 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5050) Ig_4 PF16680.5 PIK42942.1 - 0.025 14.8 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK42942.1 - 0.031 14.3 0.0 0.083 13.0 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain Adeno_E3_CR1 PF02440.15 PIK42942.1 - 0.069 12.9 0.3 1.2 8.9 0.3 2.4 1 1 0 1 1 1 0 Adenovirus E3 region protein CR1 Ig_5 PF16681.5 PIK42942.1 - 0.13 12.7 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain OATP PF03137.20 PIK42943.1 - 7.5e-118 394.2 12.6 8.3e-98 328.0 7.4 2.1 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK42943.1 - 5.9e-13 48.5 21.6 5.9e-13 48.5 21.6 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK42943.1 - 0.0064 15.4 5.5 0.68 8.7 1.5 2.9 3 0 0 3 3 3 2 MFS_1 like family UNC-93 PF05978.16 PIK42943.1 - 1.4 8.6 7.3 0.079 12.7 0.8 2.2 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 OATP PF03137.20 PIK42944.1 - 1.7e-72 244.4 8.4 2.4e-72 244.0 8.4 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK42944.1 - 1e-06 28.0 10.0 4.3e-06 25.9 0.2 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK42944.1 - 4.2e-05 23.6 13.1 9.9e-05 22.4 13.1 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK42944.1 - 0.0067 16.4 6.3 0.015 15.3 6.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.7 PIK42944.1 - 0.015 14.2 1.2 0.43 9.4 0.2 2.5 2 0 0 2 2 2 0 MFS_1 like family DUF2207 PF09972.9 PIK42944.1 - 0.51 9.0 2.3 0.25 10.0 0.2 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) OATP PF03137.20 PIK42945.1 - 3.4e-51 174.2 6.6 3.9e-51 174.0 6.6 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK42945.1 - 9.6e-07 28.0 21.4 7.7e-06 25.1 21.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily PSI PF01437.25 PIK42945.1 - 0.19 12.3 0.7 0.39 11.3 0.2 1.7 2 0 0 2 2 2 0 Plexin repeat cNMP_binding PF00027.29 PIK42946.1 - 0.0017 18.4 0.0 0.097 12.8 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pilin_PilA PF14245.6 PIK42946.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Type IV pilin PilA HMG_box PF00505.19 PIK42947.1 - 5e-27 94.1 75.3 1.5e-12 47.7 7.7 7.5 6 1 1 7 7 7 4 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK42947.1 - 2.6e-08 34.3 55.6 0.0021 18.6 8.8 6.6 6 1 1 7 7 7 4 HMG-box domain HMG_box_5 PF14887.6 PIK42947.1 - 0.0025 17.8 1.7 0.0025 17.8 1.7 5.1 4 1 1 5 5 5 2 HMG (high mobility group) box 5 7tm_1 PF00001.21 PIK42948.1 - 7.9e-29 100.8 17.2 1.2e-28 100.2 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) EamA PF00892.20 PIK42949.1 - 2.3e-13 50.5 31.2 2.8e-08 34.0 13.8 2.4 2 1 0 2 2 2 2 EamA-like transporter family DUF2768 PF10966.8 PIK42949.1 - 0.16 12.4 4.4 0.26 11.7 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2768) Multi_Drug_Res PF00893.19 PIK42949.1 - 3.5 8.4 18.3 1.4 9.6 2.0 3.6 3 1 1 4 4 4 0 Small Multidrug Resistance protein zf-CCHC PF00098.23 PIK42950.1 - 0.0023 17.9 3.3 0.0023 17.9 3.3 3.3 4 0 0 4 4 4 1 Zinc knuckle zf-RING_UBOX PF13445.6 PIK42951.1 - 9.5e-10 38.3 7.3 9.5e-10 38.3 7.3 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK42951.1 - 1.7e-09 37.4 10.5 1.7e-09 37.4 10.5 3.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK42951.1 - 1e-08 34.9 7.3 1e-08 34.9 7.3 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK42951.1 - 2.1e-07 31.2 9.0 2.1e-07 31.2 9.0 3.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK42951.1 - 3.7e-07 29.9 11.0 3.7e-07 29.9 11.0 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK42951.1 - 7.5e-07 29.2 9.5 7.5e-07 29.2 9.5 3.8 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK42951.1 - 4.8e-05 23.2 9.2 4.8e-05 23.2 9.2 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK42951.1 - 0.00011 22.3 29.4 0.00056 20.0 13.8 4.3 5 0 0 5 5 4 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK42951.1 - 0.00081 19.2 7.6 0.00081 19.2 7.6 3.8 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 Nucleoporin2 PF04096.14 PIK42951.1 - 0.082 13.0 3.1 3 7.9 2.4 2.6 2 0 0 2 2 2 0 Nucleoporin autopeptidase Methyltransf_12 PF08242.12 PIK42951.1 - 0.14 13.0 0.5 1.2 10.0 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_L17 PF01196.19 PIK42951.1 - 0.28 12.1 4.2 0.37 11.7 1.7 2.3 2 0 0 2 2 2 0 Ribosomal protein L17 zinc-ribbons_6 PF07191.12 PIK42951.1 - 0.4 10.7 32.4 0.15 12.1 6.1 4.2 3 1 1 4 4 4 0 zinc-ribbons CENP-C_mid PF15620.6 PIK42951.1 - 0.94 9.4 12.5 1.6 8.7 12.5 1.3 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region DUF3552 PF12072.8 PIK42951.1 - 8.6 5.7 20.3 3.2 7.1 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) RVT_1 PF00078.27 PIK42952.1 - 2.9e-24 85.8 0.0 1e-23 84.1 0.0 2.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK42952.1 - 1.1e-12 47.8 0.2 3.4e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK42952.1 - 1.9e-05 24.8 0.0 3.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain AphA_like PF14557.6 PIK42952.1 - 0.026 14.2 0.0 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 Putative AphA-like transcriptional regulator zf-H2C2 PF09337.10 PIK42952.1 - 0.068 13.4 0.1 0.32 11.3 0.1 2.1 2 0 0 2 2 2 0 H2C2 zinc finger zf-C3HC4 PF00097.25 PIK42953.1 - 2.4e-09 36.9 11.6 2.4e-09 36.9 11.6 3.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK42953.1 - 7.1e-09 35.6 8.2 7.1e-09 35.6 8.2 2.8 3 0 0 3 3 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK42953.1 - 3e-07 30.7 9.1 3e-07 30.7 9.1 4.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK42953.1 - 7.7e-07 28.9 10.6 7.7e-07 28.9 10.6 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK42953.1 - 3.1e-06 26.9 11.5 3.1e-06 26.9 11.5 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK42953.1 - 3.7e-06 27.0 10.6 3.7e-06 27.0 10.6 3.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK42953.1 - 6.6e-05 22.8 10.3 6.6e-05 22.8 10.3 3.9 3 0 0 3 3 2 1 zinc-RING finger domain zf-B_box PF00643.24 PIK42953.1 - 0.00044 20.3 9.5 0.00044 20.3 9.5 4.4 4 0 0 4 4 4 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK42953.1 - 0.0044 16.9 11.7 0.0044 16.9 11.7 3.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 Myb_DNA-bind_5 PF13873.6 PIK42953.1 - 0.027 14.5 0.7 0.13 12.4 0.1 2.5 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain MOR2-PAG1_C PF14225.6 PIK42953.1 - 0.04 13.8 0.3 0.088 12.7 0.3 1.6 1 0 0 1 1 1 0 Cell morphogenesis C-terminal HTH_26 PF13443.6 PIK42953.1 - 0.067 13.6 0.5 0.25 11.8 0.2 2.1 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Fzo_mitofusin PF04799.13 PIK42953.1 - 6.6 6.3 7.7 9 5.8 4.5 2.5 1 1 1 2 2 2 0 fzo-like conserved region WD40 PF00400.32 PIK42954.1 - 0.095 13.6 0.6 21 6.2 0.0 2.8 2 0 0 2 2 2 0 WD domain, G-beta repeat IGR PF09597.10 PIK42955.1 - 0.02 15.0 2.4 9.6 6.4 0.2 3.6 4 0 0 4 4 4 0 IGR protein motif Peptidase_U49 PF10463.9 PIK42955.1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase U49 DUF2783 PF10932.8 PIK42955.1 - 0.19 11.4 0.0 0.44 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) ubiquitin PF00240.23 PIK42957.1 - 8.8e-06 25.4 0.0 8.8e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family DUF4207 PF13904.6 PIK42957.1 - 3.9e-05 23.5 12.6 5.8e-05 22.9 12.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Ubiquitin_2 PF14560.6 PIK42957.1 - 0.0043 17.5 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain Pal1 PF08316.11 PIK42957.1 - 0.32 11.7 2.7 2.7 8.7 3.6 2.0 2 0 0 2 2 2 0 Pal1 cell morphology protein PA26 PF04636.13 PIK42957.1 - 1.4 7.7 4.4 2.1 7.2 4.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RR_TM4-6 PF06459.12 PIK42957.1 - 2.2 8.0 9.4 2.9 7.7 9.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RVT_1 PF00078.27 PIK42958.1 - 3.8e-07 29.8 0.1 6.2e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cullin_Nedd8 PF10557.9 PIK42958.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Cullin protein neddylation domain MIP PF00230.20 PIK42959.1 - 2e-45 155.2 6.7 2.7e-45 154.8 6.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein tRNA-synt_2_TM PF16995.5 PIK42959.1 - 0.58 9.8 9.3 0.052 13.2 4.9 1.5 2 0 0 2 2 2 0 Transmembrane region of lysyl-tRNA synthetase MFS_1 PF07690.16 PIK42961.1 - 6.7e-27 94.3 30.1 1.2e-14 54.0 10.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4229 PF14012.6 PIK42961.1 - 0.14 12.3 0.1 0.14 12.3 0.1 4.0 5 1 0 5 5 5 0 Protein of unknown function (DUF4229) DUF5534 PF17686.1 PIK42961.1 - 4.3 7.5 4.8 0.78 10.0 0.1 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5534) MFS_1 PF07690.16 PIK42963.1 - 1.1e-05 24.6 10.0 1.5e-05 24.1 10.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily YrpD PF15493.6 PIK42963.1 - 0.083 12.7 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, YrpD DUF5534 PF17686.1 PIK42963.1 - 0.098 12.9 0.3 0.26 11.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5534) MFS_1 PF07690.16 PIK42964.1 - 8.1e-05 21.7 3.2 0.054 12.4 1.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NUP PF06516.11 PIK42964.1 - 0.13 11.4 0.1 0.18 11.0 0.1 1.2 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) DUF4229 PF14012.6 PIK42964.1 - 0.29 11.2 6.7 0.57 10.3 5.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4229) HEPN PF05168.14 PIK42965.1 - 1.8e-07 31.3 1.2 1.1e-06 28.7 0.0 2.7 3 0 0 3 3 3 1 HEPN domain DnaJ PF00226.31 PIK42965.1 - 9.2e-05 22.5 0.1 0.00041 20.4 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain LMP PF04778.12 PIK42965.1 - 0.2 11.6 0.1 0.5 10.3 0.1 1.6 1 0 0 1 1 1 0 LMP repeated region Fibrinogen_C PF00147.18 PIK42966.1 - 4.2e-64 216.4 10.9 4.8e-64 216.2 10.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK42966.1 - 0.21 11.5 1.7 0.66 9.9 1.7 1.8 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) C2-set_2 PF08205.12 PIK42967.1 - 0.00014 21.8 6.3 0.035 14.2 0.6 3.7 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK42967.1 - 0.0011 19.1 0.5 0.089 13.0 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK42967.1 - 0.0029 18.0 1.4 0.7 10.3 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin C1-set domain AAA_25 PF13481.6 PIK42967.1 - 0.07 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 PIK42967.1 - 0.24 11.3 2.6 0.14 12.1 0.2 1.8 2 0 0 2 2 2 0 TMEM154 protein family Pkinase_Tyr PF07714.17 PIK42969.1 - 3e-27 95.5 0.0 4.7e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK42969.1 - 1.8e-19 70.2 0.0 3.5e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK42969.1 - 5.5e-12 46.1 1.8 0.0045 17.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK42969.1 - 1.1e-08 35.0 0.6 0.00039 20.4 0.1 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK42969.1 - 0.00033 21.0 0.2 0.14 12.6 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin C1-set domain I-set PF07679.16 PIK42969.1 - 0.00036 20.5 0.6 2 8.6 0.2 3.4 3 2 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK42969.1 - 0.00054 20.2 2.4 0.29 11.5 0.3 3.9 3 1 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK42969.1 - 0.011 15.9 5.4 1.5 9.0 0.0 3.5 3 1 0 3 3 3 0 Immunoglobulin domain V-set PF07686.17 PIK42969.1 - 0.017 15.3 0.1 0.17 12.0 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin V-set domain NACHT PF05729.12 PIK42970.1 - 8.2e-16 58.4 0.0 1.6e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK42970.1 - 0.0042 16.7 0.0 0.009 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain V-set PF07686.17 PIK42970.1 - 0.012 15.8 3.2 0.65 10.2 0.3 4.0 4 0 0 4 4 4 0 Immunoglobulin V-set domain DAP3 PF10236.9 PIK42970.1 - 0.045 12.9 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 zf-H3C2 PF16721.5 PIK42970.1 - 0.067 13.6 0.1 1.8 8.9 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger like, probable DNA-binding AAA PF00004.29 PIK42970.1 - 0.068 13.6 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GPI2 PF06432.11 PIK42970.1 - 0.088 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Izumo-Ig PF16706.5 PIK42970.1 - 0.1 12.7 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain AAA_22 PF13401.6 PIK42970.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_L5_C PF00673.21 PIK42971.1 - 5.2e-21 74.6 0.0 7e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 PIK42971.1 - 6.1e-14 52.1 0.0 3.1e-12 46.6 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L5 PMEI PF04043.15 PIK42971.1 - 0.17 12.2 0.0 0.21 11.9 0.0 1.1 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor MIR PF02815.19 PIK42972.1 - 2.4e-12 47.1 0.2 2.6e-09 37.2 0.1 2.1 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.11 PIK42972.1 - 0.059 12.5 0.1 9.2 5.4 0.0 2.1 1 1 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor CAMSAP_CH PF11971.8 PIK42973.1 - 3.2e-30 103.8 0.6 8e-30 102.5 0.6 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.31 PIK42973.1 - 4.9e-05 23.5 0.6 0.00022 21.4 0.1 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 PIK42973.1 - 0.0065 16.6 0.0 0.027 14.6 0.0 2.1 2 0 0 2 2 2 1 CH-like domain in sperm protein DUF4698 PF15769.5 PIK42974.1 - 0.00023 20.3 0.9 0.00023 20.3 0.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4698) Mito_carr PF00153.27 PIK42975.1 - 4.3e-33 113.1 1.8 8.9e-11 41.6 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein LPD30 PF18850.1 PIK42976.1 - 0.044 13.5 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 FAD_binding_2 PF00890.24 PIK42978.1 - 8.1e-130 433.6 3.0 9.3e-130 433.4 2.3 1.5 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.20 PIK42978.1 - 1.6e-39 134.8 0.1 2.6e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 PIK42978.1 - 3.9e-06 26.3 0.5 0.00064 19.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK42978.1 - 1.5e-05 24.3 0.2 0.026 13.8 0.0 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 PIK42978.1 - 8.3e-05 21.8 1.5 0.03 13.4 2.3 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 PIK42978.1 - 0.026 13.8 0.2 0.047 12.9 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain AAA_22 PF13401.6 PIK42979.1 - 4.4e-05 23.8 0.1 0.0021 18.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK42979.1 - 0.032 14.6 0.0 0.12 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activat PF00158.26 PIK42979.1 - 0.039 13.7 0.0 0.094 12.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Polo_box_3 PF18544.1 PIK42979.1 - 0.067 13.8 1.2 0.97 10.1 0.0 2.8 2 0 0 2 2 2 0 Polo box domain YvbH_ext PF11724.8 PIK42979.1 - 0.09 13.1 0.9 8.1 6.9 0.0 3.6 3 0 0 3 3 3 0 YvbH-like oligomerisation region T2SSE PF00437.20 PIK42979.1 - 0.15 11.1 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein CBFD_NFYB_HMF PF00808.23 PIK42980.1 - 1.3e-20 73.4 0.4 3e-20 72.2 0.4 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 PIK42980.1 - 1.7e-05 24.9 0.2 3.5e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 CENP-W protein Histone PF00125.24 PIK42980.1 - 0.0028 18.0 1.8 0.0036 17.6 0.0 2.0 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 Nup188 PF10487.9 PIK42981.1 - 3e-83 280.3 1.9 2.7e-58 197.7 0.1 2.9 3 0 0 3 3 3 2 Nucleoporin subcomplex protein binding to Pom34 CBM_10 PF02013.16 PIK42982.1 - 0.074 13.5 0.7 0.074 13.5 0.7 2.5 2 0 0 2 2 2 0 Cellulose or protein binding domain PSP94 PF05825.11 PIK42982.1 - 1.6 9.3 12.7 4.5 7.9 12.7 1.7 1 1 0 1 1 1 0 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42983.1 - 0.0081 16.7 10.9 0.099 13.2 9.4 2.1 1 1 1 2 2 2 2 Beta-microseminoprotein (PSP-94) Metallothio_6 PF05522.11 PIK42983.1 - 0.26 11.8 9.3 0.68 10.5 9.3 1.8 1 1 0 1 1 1 0 Metallothionein PSP94 PF05825.11 PIK42984.1 - 7.1e-05 23.3 6.3 9.6e-05 22.9 6.3 1.2 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42985.1 - 0.00016 22.2 6.9 0.00021 21.8 6.9 1.3 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42986.1 - 0.00049 20.6 7.7 0.00064 20.2 7.7 1.2 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) DUF5488 PF17590.2 PIK42987.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5488) PSP94 PF05825.11 PIK42987.1 - 0.025 15.1 5.5 0.04 14.5 5.5 1.3 1 0 0 1 1 1 0 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42988.1 - 0.0041 17.6 7.1 0.0062 17.1 7.1 1.4 1 1 0 1 1 1 1 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42989.1 - 0.77 10.4 10.8 0.32 11.6 8.7 1.4 1 1 0 1 1 1 0 Beta-microseminoprotein (PSP-94) PRKCSH-like PF12999.7 PIK42989.1 - 3.6 7.4 10.3 13 5.6 9.8 1.9 1 1 1 2 2 2 0 Glucosidase II beta subunit-like PSP94 PF05825.11 PIK42990.1 - 0.0021 18.6 8.3 0.0027 18.2 8.3 1.3 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) PSP94 PF05825.11 PIK42991.1 - 0.036 14.6 26.8 0.15 12.6 10.2 2.5 2 1 0 2 2 2 0 Beta-microseminoprotein (PSP-94) Fungus-induced PF10917.8 PIK42991.1 - 0.36 11.2 1.0 19 5.7 0.1 2.4 2 0 0 2 2 2 0 Fungus-induced protein PSP94 PF05825.11 PIK42993.1 - 0.00076 20.0 9.5 0.00076 20.0 9.5 1.6 1 1 1 2 2 2 1 Beta-microseminoprotein (PSP-94) 7tm_1 PF00001.21 PIK42994.1 - 7e-14 51.8 0.5 9.9e-14 51.3 0.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sigma_reg_N PF13800.6 PIK42994.1 - 0.012 15.9 4.9 0.017 15.4 1.0 2.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Put_Phosphatase PF06888.12 PIK42995.1 - 6.7e-54 182.8 0.4 8e-54 182.5 0.4 1.1 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 PIK42995.1 - 1.7e-06 28.6 0.0 4.7e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_tranf_2_4 PF13704.6 PIK42995.1 - 0.0097 16.4 0.0 0.33 11.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF3524 PF12038.8 PIK42996.1 - 2.7e-66 222.5 0.7 3.8e-66 222.1 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3524) Citrate_bind PF16114.5 PIK42997.1 - 5.3e-92 306.2 0.2 9.5e-92 305.4 0.2 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 PIK42997.1 - 1.5e-21 76.9 0.0 8.8e-20 71.1 0.0 2.6 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 PIK42997.1 - 4.9e-14 52.4 0.0 9.8e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 PIK42997.1 - 1.1e-13 51.7 0.0 2.5e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 PIK42997.1 - 1.1e-08 34.9 0.0 5.2e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 PIK42997.1 - 0.00069 19.4 0.0 0.003 17.4 0.0 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Patatin PF01734.22 PIK42998.1 - 2.7e-24 86.5 0.0 5.3e-24 85.5 0.0 1.5 1 1 0 1 1 1 1 Patatin-like phospholipase DUF5028 PF16431.5 PIK42998.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) EF-hand_6 PF13405.6 PIK42999.1 - 7.2e-07 28.6 2.7 0.00061 19.5 0.1 3.0 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK42999.1 - 8.3e-07 28.1 1.3 0.00055 19.3 0.2 3.6 3 1 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 PIK42999.1 - 9.9e-06 25.9 2.3 3.2e-05 24.3 1.7 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK42999.1 - 5.9e-05 22.4 0.5 0.00072 18.9 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 PIK42999.1 - 0.0064 16.3 0.9 0.029 14.2 0.5 2.4 2 1 0 2 2 2 1 EF-hand domain pair 7tm_1 PF00001.21 PIK43000.1 - 9.2e-56 189.1 24.5 1.1e-55 188.8 24.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK43000.1 - 7.6e-11 41.9 0.4 7.6e-11 41.9 0.4 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 PIK43000.1 - 2.4e-08 33.7 19.7 3.3e-08 33.2 19.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK43000.1 - 2.3e-07 30.5 21.0 9.2e-07 28.5 19.6 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK43000.1 - 7.7e-06 25.8 14.8 1.5e-05 24.9 6.7 2.1 2 0 0 2 2 2 2 Olfactory receptor P34-Arc PF04045.14 PIK43001.1 - 4e-100 334.5 0.5 4.7e-100 334.2 0.5 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc DUF2737 PF10930.8 PIK43001.1 - 0.081 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Coq4 PF05019.13 PIK43001.1 - 0.24 10.7 0.0 0.24 10.7 0.0 1.5 2 0 0 2 2 2 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 RT_RNaseH_2 PF17919.1 PIK43002.1 - 3.4e-36 123.3 0.0 6.6e-36 122.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK43002.1 - 4e-34 117.1 0.0 7.5e-34 116.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK43002.1 - 1.1e-15 57.5 2.7 1.1e-15 57.5 2.7 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK43002.1 - 1.2e-10 41.3 0.0 2.5e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK43002.1 - 2.6e-05 24.4 0.0 8.4e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.6 PIK43002.1 - 4.6e-05 23.9 0.1 0.00013 22.5 0.0 1.8 2 0 0 2 2 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK43002.1 - 0.00033 21.2 0.1 0.00087 19.9 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK43002.1 - 0.00051 20.3 0.1 0.0014 18.9 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 PIK43002.1 - 0.0016 18.6 0.0 0.078 13.1 0.0 2.6 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) MLVIN_C PF18697.1 PIK43002.1 - 0.0082 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease PF09668.10 PIK43002.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease C2-set_2 PF08205.12 PIK43003.1 - 1.7e-06 28.0 1.1 0.0066 16.5 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK43003.1 - 2.8e-06 27.6 1.1 0.078 13.3 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK43003.1 - 6.9e-06 26.6 3.5 0.041 14.5 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK43003.1 - 0.00091 19.4 0.3 0.016 15.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK43003.1 - 0.0049 17.0 2.6 0.36 11.0 0.0 3.1 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK43003.1 - 0.0062 16.6 0.1 2.5 8.2 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain GOLD_2 PF13897.6 PIK43003.1 - 0.085 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking ATG101 PF07855.12 PIK43004.1 - 0.0023 17.9 0.1 0.0036 17.3 0.1 1.3 1 0 0 1 1 1 1 Autophagy-related protein 101 NACHT PF05729.12 PIK43007.1 - 1.5e-08 34.7 0.0 2.5e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain DUF3657 PF12394.8 PIK43008.1 - 1.6e-13 51.0 0.8 2.8e-13 50.2 0.8 1.4 1 0 0 1 1 1 1 Protein FAM135 DUF676 PF05057.14 PIK43011.1 - 1.7e-54 184.7 0.0 2.1e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 PIK43011.1 - 7.1e-10 39.1 0.0 8.2e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 PIK43011.1 - 2.6e-06 27.3 0.0 3.7e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 PIK43011.1 - 0.00034 19.9 0.0 0.00047 19.5 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.20 PIK43011.1 - 0.0065 16.1 0.3 0.23 11.0 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK43011.1 - 0.059 14.0 0.0 0.077 13.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Exo_endo_phos_2 PF14529.6 PIK43012.1 - 1.4e-10 41.1 0.0 2.7e-10 40.1 0.0 1.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK43012.1 - 1.1e-07 31.7 0.0 1.8e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fibrinogen_C PF00147.18 PIK43014.1 - 1.7e-42 145.8 1.7 3.2e-42 144.8 1.7 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK43014.1 - 1.3e-06 28.4 7.0 1.3e-06 28.4 7.0 4.6 5 1 0 5 5 5 1 EGF domain TILa PF12714.7 PIK43014.1 - 0.00036 20.4 5.8 0.00036 20.4 5.8 2.4 1 1 0 1 1 1 1 TILa domain EGF_Tenascin PF18720.1 PIK43014.1 - 0.15 12.1 4.4 3.4 7.8 0.1 3.2 1 1 1 2 2 2 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK43015.1 - 5.2e-30 104.9 0.7 1.3e-29 103.6 0.7 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK43015.1 - 9.1e-07 29.0 7.6 9.1e-07 29.0 7.6 3.6 4 0 0 4 4 4 1 EGF domain TILa PF12714.7 PIK43015.1 - 0.00036 20.4 6.6 0.00036 20.4 6.6 2.3 1 1 1 2 2 2 1 TILa domain NUDIX PF00293.28 PIK43016.1 - 2.7e-14 53.4 0.0 3.7e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain CortBP2 PF09727.9 PIK43017.1 - 1.2e-35 123.2 18.7 1.2e-35 123.2 18.7 2.6 3 0 0 3 3 3 1 Cortactin-binding protein-2 Ank_2 PF12796.7 PIK43017.1 - 2.4e-32 111.4 1.0 5.3e-16 59.0 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43017.1 - 7.8e-27 93.3 2.0 8.2e-11 42.2 0.0 4.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK43017.1 - 7e-23 80.4 5.2 2.9e-06 27.4 0.0 6.5 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK43017.1 - 1.3e-17 63.4 3.8 7.1e-07 29.4 0.1 6.2 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 PIK43017.1 - 1.5e-16 58.8 2.3 0.012 16.1 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat AAA_5 PF07728.14 PIK43017.1 - 5.2e-06 26.5 0.0 3e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 PIK43017.1 - 0.0077 16.7 0.4 0.057 13.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 PIK43017.1 - 0.051 13.1 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 PIK43017.1 - 0.089 12.7 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 PIK43017.1 - 0.11 12.9 0.0 0.11 12.9 0.0 3.4 3 1 0 3 3 2 0 AAA ATPase domain ATPase_2 PF01637.18 PIK43017.1 - 0.63 9.9 0.0 0.63 9.9 0.0 3.0 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea ERM PF00769.19 PIK43017.1 - 0.99 9.2 43.0 0.058 13.2 19.0 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family EF-hand_7 PF13499.6 PIK43018.1 - 1.1e-06 29.0 2.9 2.3e-05 24.7 0.8 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK43018.1 - 1.4e-06 27.8 3.6 0.0061 16.4 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK43018.1 - 4.8e-05 22.6 4.8 0.083 12.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 PIK43018.1 - 0.02 14.3 0.0 0.074 12.6 0.0 2.0 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 PIK43018.1 - 0.058 13.2 0.8 0.19 11.6 0.4 2.0 2 0 0 2 2 2 0 EF-hand domain pair RRT14 PF17075.5 PIK43018.1 - 0.077 13.1 0.4 0.49 10.5 0.0 2.1 2 0 0 2 2 2 0 Regular of rDNA transcription protein 14 tRNA_m1G_MT PF01746.21 PIK43019.1 - 2e-24 86.4 0.0 3.4e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Kelch_6 PF13964.6 PIK43019.1 - 0.17 12.2 0.0 0.44 10.9 0.0 1.7 1 0 0 1 1 1 0 Kelch motif BicD PF09730.9 PIK43020.1 - 8.7e-44 150.1 27.0 1.1e-43 149.7 27.0 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D HALZ PF02183.18 PIK43020.1 - 0.0011 19.1 20.6 0.0037 17.5 0.3 4.8 4 1 1 5 5 5 3 Homeobox associated leucine zipper DUF4164 PF13747.6 PIK43020.1 - 0.033 14.5 19.1 0.076 13.3 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF4407 PF14362.6 PIK43020.1 - 0.19 11.0 7.1 0.23 10.8 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 PIK43020.1 - 0.32 9.8 23.1 0.29 10.0 22.0 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 PIK43020.1 - 0.48 10.5 19.3 0.2 11.7 6.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 PIK43020.1 - 0.91 10.0 21.8 0.84 10.1 1.2 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) LMBR1 PF04791.16 PIK43020.1 - 1 8.2 13.6 1.2 7.9 13.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein UvsY PF11056.8 PIK43020.1 - 1.6 9.1 10.5 0.17 12.2 1.0 2.4 1 1 1 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Ribosomal_S13 PF00416.22 PIK43020.1 - 2.4 8.6 8.7 0.86 10.0 5.2 2.0 1 1 1 2 2 2 0 Ribosomal protein S13/S18 DUF4201 PF13870.6 PIK43020.1 - 2.4 7.8 30.6 0.27 10.9 9.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) PI_PP_I PF18363.1 PIK43020.1 - 2.6 8.3 9.1 0.47 10.7 1.5 2.6 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain Occludin_ELL PF07303.13 PIK43020.1 - 9 7.1 18.5 6.1 7.6 0.5 2.8 1 1 3 4 4 4 0 Occludin homology domain BicD PF09730.9 PIK43021.1 - 3e-90 303.7 19.1 3.6e-90 303.4 19.1 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D DUF1759 PF03564.15 PIK43021.1 - 0.0012 18.8 7.9 0.002 18.1 6.3 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF1759) Rab5-bind PF09311.11 PIK43021.1 - 0.023 14.1 15.5 0.042 13.3 15.5 1.4 1 0 0 1 1 1 0 Rabaptin-like protein GAS PF13851.6 PIK43021.1 - 0.11 11.9 21.9 1.2 8.4 10.7 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK43021.1 - 0.15 10.9 17.5 0.12 11.2 13.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1779 PF08680.10 PIK43021.1 - 0.34 11.1 6.0 0.6 10.3 6.0 1.3 1 0 0 1 1 1 0 TATA-box binding FlgN PF05130.12 PIK43021.1 - 0.73 10.3 18.0 0.085 13.4 4.8 2.4 1 1 1 2 2 2 0 FlgN protein GLTP PF08718.11 PIK43021.1 - 1.1 9.5 8.2 3 8.1 2.6 2.6 1 1 2 3 3 3 0 Glycolipid transfer protein (GLTP) FUSC PF04632.12 PIK43021.1 - 1.8 7.0 8.9 2.7 6.4 8.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ank_2 PF12796.7 PIK43023.1 - 2.6e-11 44.0 0.0 1.5e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK43023.1 - 4.2e-09 36.5 0.5 5.8e-06 26.5 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK43023.1 - 9.2e-09 35.7 0.2 0.00018 22.0 0.0 2.7 2 1 1 3 3 2 2 Ankyrin repeats (many copies) ubiquitin PF00240.23 PIK43023.1 - 1.3e-05 24.8 0.0 1.3e-05 24.8 0.0 1.8 2 0 0 2 2 1 1 Ubiquitin family DUF4207 PF13904.6 PIK43023.1 - 2.6e-05 24.0 13.0 4.3e-05 23.3 13.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Ank PF00023.30 PIK43023.1 - 0.00021 21.6 0.0 1.6 9.3 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 PIK43023.1 - 0.0038 17.6 0.4 8.9 7.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ubiquitin_2 PF14560.6 PIK43023.1 - 0.0048 17.3 0.0 0.014 15.8 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain DotA PF11388.8 PIK43023.1 - 0.031 14.5 0.2 1.1 9.5 0.0 2.6 2 0 0 2 2 2 0 Phagosome trafficking protein DotA Pal1 PF08316.11 PIK43023.1 - 0.26 12.0 2.2 1.8 9.3 3.0 1.9 2 0 0 2 2 2 0 Pal1 cell morphology protein RR_TM4-6 PF06459.12 PIK43023.1 - 2 8.2 8.1 3 7.6 8.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PDZ PF00595.24 PIK43024.1 - 1.8e-09 37.8 0.0 2.7e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PB1 PF00564.24 PIK43024.1 - 4.2e-09 36.2 0.0 6.4e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 PB1 domain PDZ_6 PF17820.1 PIK43024.1 - 1.7e-05 24.6 0.0 2.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain G-alpha PF00503.20 PIK43025.1 - 8.4e-90 301.5 3.3 1e-89 301.2 3.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK43025.1 - 1.3e-13 50.8 0.8 2.8e-13 49.7 0.8 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK43025.1 - 0.00011 21.6 0.1 0.00018 20.9 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK43025.1 - 0.0072 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 PIK43025.1 - 0.016 15.4 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase EF-hand_5 PF13202.6 PIK43026.1 - 8.1e-11 40.9 0.0 0.00057 19.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 PIK43026.1 - 4.7e-09 35.1 0.4 0.003 17.0 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK43026.1 - 2.1e-07 31.3 0.3 1.4e-06 28.7 0.3 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK43026.1 - 8e-07 28.5 0.4 0.054 13.5 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain RGM_N PF06535.12 PIK43026.1 - 0.00076 19.7 8.5 0.15 12.2 0.3 2.3 1 1 0 2 2 2 2 Repulsive guidance molecule (RGM) N-terminus EF-hand_8 PF13833.6 PIK43026.1 - 0.0023 17.7 0.1 0.87 9.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair DUF1397 PF07165.11 PIK43026.1 - 0.02 14.3 0.7 0.02 14.3 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1397) CPG4 PF15481.6 PIK43026.1 - 0.034 14.7 7.4 0.21 12.3 2.8 2.4 2 0 0 2 2 2 0 Chondroitin proteoglycan 4 SPARC_Ca_bdg PF10591.9 PIK43026.1 - 0.039 14.3 0.5 0.29 11.5 0.0 2.4 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Colicin PF01024.19 PIK43026.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Colicin pore forming domain PhoLip_ATPase_C PF16212.5 PIK43027.1 - 1.6e-49 169.0 23.4 1.6e-49 169.0 23.4 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 PIK43027.1 - 6.3e-15 54.6 4.3 6.3e-15 54.6 4.3 1.9 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 PIK43027.1 - 1.3e-13 51.8 0.5 3.9e-08 33.8 0.2 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK43027.1 - 7.4e-10 38.8 0.0 1.2e-08 34.9 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 PIK43027.1 - 0.009 15.8 0.1 0.03 14.1 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 PIK43027.1 - 0.035 13.6 0.1 0.035 13.6 0.1 3.3 3 0 0 3 3 3 0 E1-E2 ATPase rve PF00665.26 PIK43029.1 - 6.6e-07 29.5 0.0 3.4e-06 27.2 0.0 2.0 2 1 0 2 2 2 1 Integrase core domain GerE PF00196.19 PIK43029.1 - 0.009 15.5 0.1 0.018 14.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_23 PF13384.6 PIK43029.1 - 0.0092 15.8 0.1 0.034 14.0 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 PIK43029.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Glyco_transf_7N PF13733.6 PIK43030.1 - 1.3e-35 121.9 0.2 2e-35 121.4 0.2 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 PIK43030.1 - 2.3e-15 56.0 0.8 6.5e-15 54.5 0.4 1.9 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase PDE6_gamma PF04868.12 PIK43032.1 - 0.14 12.4 0.9 0.25 11.6 0.1 1.8 2 0 0 2 2 2 0 Retinal cGMP phosphodiesterase, gamma subunit Ion_trans PF00520.31 PIK43033.1 - 5.3e-60 202.7 9.3 6.2e-60 202.5 9.3 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK43033.1 - 0.00038 19.3 15.9 0.0043 15.8 1.4 3.0 3 0 0 3 3 3 3 Polycystin cation channel SLATT_6 PF18169.1 PIK43033.1 - 0.1 12.2 2.8 0.42 10.2 0.1 2.3 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 HTH_25 PF13413.6 PIK43034.1 - 0.049 13.5 0.8 0.076 12.9 0.8 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain TMEM141 PF15110.6 PIK43035.1 - 1.2e-17 64.2 0.1 1.7e-17 63.7 0.1 1.2 1 0 0 1 1 1 1 TMEM141 protein family Ank_2 PF12796.7 PIK43037.1 - 4.3e-09 36.8 0.0 7.1e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43037.1 - 6.7e-09 36.1 1.2 5.3e-05 23.7 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK43037.1 - 5.4e-08 32.9 0.2 6e-05 23.3 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK43037.1 - 3.6e-07 30.0 0.1 0.00065 20.0 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 PIK43037.1 - 1.5e-05 25.2 0.4 6e-05 23.3 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 PIK43038.1 - 8e-61 202.6 12.0 3e-11 43.7 0.3 6.5 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43038.1 - 1.1e-56 188.5 14.4 3.5e-13 49.8 0.0 8.2 4 3 5 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK43038.1 - 3.5e-49 159.0 10.7 0.00078 19.7 0.0 12.0 11 0 0 11 11 11 10 Ankyrin repeat Ank PF00023.30 PIK43038.1 - 1.3e-47 158.2 13.4 5.7e-06 26.5 0.0 10.6 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.6 PIK43038.1 - 4.5e-46 154.3 12.8 3.3e-08 33.6 0.0 8.9 2 2 8 10 10 10 9 Ankyrin repeats (many copies) Ion_trans PF00520.31 PIK43038.1 - 1.3e-11 44.3 20.7 2e-11 43.6 20.7 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3447 PF11929.8 PIK43038.1 - 0.00013 21.8 0.1 0.02 14.8 0.0 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3447) Nucleos_tra2_C PF07662.13 PIK43038.1 - 0.1 12.4 1.0 0.23 11.3 0.3 1.9 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus Osmo_CC PF08946.10 PIK43038.1 - 0.16 12.2 0.3 0.81 10.0 0.3 2.3 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Death PF00531.22 PIK43039.1 - 8.6e-16 57.9 1.1 6.5e-06 26.2 0.0 3.4 3 0 0 3 3 3 3 Death domain CPT_N PF16484.5 PIK43039.1 - 0.018 15.0 0.1 0.062 13.3 0.0 1.9 2 0 0 2 2 2 0 Carnitine O-palmitoyltransferase N-terminus CAP_GLY PF01302.25 PIK43040.1 - 1.2e-12 47.6 0.2 3.4e-12 46.2 0.2 1.8 1 0 0 1 1 1 1 CAP-Gly domain DUF4687 PF15747.5 PIK43040.1 - 2.6 8.5 4.5 42 4.7 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4687) Neuralized PF07177.12 PIK43041.1 - 1.8e-13 50.7 0.0 2.7e-11 43.7 0.0 2.6 1 1 0 1 1 1 1 Neuralized SOCS_box PF07525.16 PIK43041.1 - 1.8e-09 37.8 2.0 3.4e-09 36.9 2.0 1.4 1 0 0 1 1 1 1 SOCS box WD40 PF00400.32 PIK43042.1 - 3.8e-20 71.8 12.1 3.8e-07 30.7 0.0 7.3 6 1 1 7 7 7 4 WD domain, G-beta repeat HPS3_N PF14761.6 PIK43042.1 - 0.092 12.3 0.0 25 4.3 0.0 3.1 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 Fucokinase PF07959.12 PIK43044.1 - 2.2e-76 257.4 0.0 4.3e-76 256.4 0.0 1.4 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.13 PIK43044.1 - 1.1e-05 25.7 0.0 3e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 PIK43044.1 - 5.1e-05 23.4 1.7 0.0001 22.5 0.2 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain DnaJ PF00226.31 PIK43045.1 - 1.5e-24 85.9 0.6 1.5e-24 85.9 0.6 2.1 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 PIK43045.1 - 2.5e-10 40.3 10.9 6.4e-10 39.1 2.8 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK43045.1 - 2.6e-07 30.9 2.9 0.0093 16.3 0.4 3.0 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK43045.1 - 1.3e-06 28.6 1.7 1.3e-06 28.6 1.7 2.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 PIK43045.1 - 0.00025 21.6 4.3 0.4 11.6 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK43045.1 - 0.0046 17.3 8.0 0.51 10.9 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-DBF PF07535.12 PIK43045.1 - 1.1 9.5 3.7 20 5.4 0.5 2.6 2 0 0 2 2 2 0 DBF zinc finger zf-C2H2_6 PF13912.6 PIK43045.1 - 1.7 8.7 4.5 12 6.1 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger 2OG-FeII_Oxy_2 PF13532.6 PIK43046.1 - 2.7e-09 37.5 0.0 3.2e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 PIK43047.1 - 2e-20 72.7 8.9 0.0005 20.8 0.2 9.6 12 0 0 12 12 12 4 WD domain, G-beta repeat WD40_like PF17005.5 PIK43047.1 - 9.6e-06 25.1 0.1 0.0012 18.2 0.0 3.4 2 1 0 3 3 3 1 WD40-like domain ANAPC4_WD40 PF12894.7 PIK43047.1 - 2.3e-05 24.6 3.9 2.7 8.3 0.1 7.1 4 3 3 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 PIK43047.1 - 0.00011 22.6 0.3 1.6 9.3 0.0 4.3 5 0 0 5 5 5 2 PQQ-like domain Nup160 PF11715.8 PIK43047.1 - 0.043 12.5 0.0 0.99 8.0 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Lactonase PF10282.9 PIK43047.1 - 0.051 12.8 0.5 0.42 9.8 0.0 2.7 3 1 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Nucleoporin_N PF08801.11 PIK43047.1 - 0.72 8.5 5.4 2.3 6.9 0.2 3.5 3 2 0 3 3 3 0 Nup133 N terminal like ATG16 PF08614.11 PIK43048.1 - 2.4e-07 31.2 64.1 2.4e-05 24.7 27.5 3.9 1 1 1 3 3 3 2 Autophagy protein 16 (ATG16) FPP PF05911.11 PIK43048.1 - 7.1e-05 21.2 20.4 7.1e-05 21.2 20.4 3.1 1 1 2 3 3 3 1 Filament-like plant protein, long coiled-coil ADIP PF11559.8 PIK43048.1 - 0.0028 17.8 35.6 0.0076 16.3 12.8 5.4 2 2 2 5 5 3 2 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 PIK43048.1 - 0.0064 16.5 10.5 0.0064 16.5 10.5 7.2 4 2 3 8 8 6 3 TATA element modulatory factor 1 DNA binding Trans_reg_C PF00486.28 PIK43048.1 - 0.0065 16.5 5.1 3.3 7.8 0.3 4.3 2 1 1 3 3 3 2 Transcriptional regulatory protein, C terminal DUF1664 PF07889.12 PIK43048.1 - 0.008 16.2 5.9 0.008 16.2 5.9 5.3 2 2 3 5 5 5 2 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 PIK43048.1 - 0.012 15.8 8.5 0.012 15.8 8.5 5.3 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 PIK43048.1 - 0.013 15.5 8.0 0.013 15.5 8.0 4.8 1 1 5 6 6 6 0 Laminin Domain II Filament PF00038.21 PIK43048.1 - 0.017 14.7 70.8 0.025 14.2 23.4 4.5 1 1 2 4 4 4 0 Intermediate filament protein Bap31_Bap29_C PF18035.1 PIK43048.1 - 0.022 14.8 4.6 0.022 14.8 4.6 8.5 8 3 0 8 8 6 0 Bap31/Bap29 cytoplasmic coiled-coil domain OmpH PF03938.14 PIK43048.1 - 0.023 15.0 14.0 0.023 15.0 14.0 4.9 2 2 2 4 4 3 0 Outer membrane protein (OmpH-like) CCDC144C PF14915.6 PIK43048.1 - 0.086 11.9 69.0 0.099 11.7 24.6 3.4 1 1 1 3 3 3 0 CCDC144C protein coiled-coil region Golgin_A5 PF09787.9 PIK43048.1 - 0.3 10.5 69.2 0.34 10.3 29.2 3.5 1 1 2 3 3 3 0 Golgin subfamily A member 5 DASH_Dam1 PF08653.10 PIK43048.1 - 0.84 9.5 8.5 3.1 7.7 0.0 4.4 3 2 2 5 5 4 0 DASH complex subunit Dam1 ERM PF00769.19 PIK43048.1 - 1 9.2 70.9 2 8.2 35.8 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family G-gamma PF00631.22 PIK43048.1 - 1.2 9.2 0.0 1.2 9.2 0.0 5.1 6 1 1 7 7 5 0 GGL domain Cnn_1N PF07989.11 PIK43048.1 - 2 8.6 72.9 0.081 13.1 1.2 7.3 2 1 5 7 7 6 0 Centrosomin N-terminal motif 1 Fez1 PF06818.15 PIK43048.1 - 2.1 8.8 65.3 4.6 7.7 24.4 4.3 1 1 2 3 3 2 0 Fez1 Mod_r PF07200.13 PIK43048.1 - 3 8.0 63.7 0.62 10.2 4.1 5.1 1 1 5 6 6 6 0 Modifier of rudimentary (Mod(r)) protein TMCO5 PF14992.6 PIK43048.1 - 3.3 7.2 65.7 0.039 13.5 11.7 4.7 1 1 3 4 4 4 0 TMCO5 family YabA PF06156.13 PIK43048.1 - 5.1 7.8 58.0 0.92 10.2 16.9 5.6 2 2 3 5 5 5 0 Initiation control protein YabA Prominin PF05478.11 PIK43048.1 - 6.4 4.6 41.3 0.13 10.2 16.5 2.3 1 1 1 2 2 2 0 Prominin DUF3584 PF12128.8 PIK43048.1 - 7.2 4.0 62.5 0.091 10.3 16.0 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3584) EzrA PF06160.12 PIK43048.1 - 7.6 4.6 61.8 0.013 13.7 15.3 3.5 2 1 2 4 4 4 0 Septation ring formation regulator, EzrA AAA_13 PF13166.6 PIK43048.1 - 9.5 4.7 58.6 0.16 10.6 41.4 2.4 1 1 1 2 2 2 0 AAA domain Steroid_dh PF02544.16 PIK43049.1 - 1.4e-17 64.0 2.1 3.2e-17 62.9 2.1 1.6 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 PIK43049.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Spc7 PF08317.11 PIK43051.1 - 0.041 12.8 90.3 0.14 11.0 8.6 4.4 2 1 2 4 4 4 0 Spc7 kinetochore protein APG6_N PF17675.1 PIK43051.1 - 1.9 9.1 101.4 0.24 11.9 20.6 5.4 1 1 4 5 5 5 0 Apg6 coiled-coil region EF-hand_2 PF09068.11 PIK43053.1 - 6.9e-27 94.0 1.1 6.9e-27 94.0 1.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.11 PIK43053.1 - 1.9e-23 82.7 0.1 1.6e-21 76.5 0.0 2.7 3 0 0 3 3 3 1 EF-hand ZZ PF00569.17 PIK43053.1 - 3e-13 49.4 11.2 6.3e-13 48.3 11.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type NARG2_C PF10505.9 PIK43055.1 - 3.6e-30 105.1 0.0 5.9e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus DUF5376 PF17346.2 PIK43058.1 - 0.053 13.9 0.0 0.28 11.5 0.0 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5376) MutS_IV PF05190.18 PIK43058.1 - 0.08 13.3 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 MutS family domain IV PCRF PF03462.18 PIK43060.1 - 1.2 8.9 8.0 1.7 8.5 7.8 1.3 1 1 0 1 1 1 0 PCRF domain Sulfotransfer_2 PF03567.14 PIK43061.1 - 5.4e-10 39.6 0.3 8.5e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Sulfotransferase family OSK PF17182.4 PIK43061.1 - 0.035 13.4 0.1 0.07 12.4 0.1 1.4 1 0 0 1 1 1 0 OSK domain TCR PF03638.15 PIK43063.1 - 0.0048 17.2 16.3 0.012 15.9 16.3 1.6 1 0 0 1 1 1 1 Tesmin/TSO1-like CXC domain, cysteine-rich domain TMEM154 PF15102.6 PIK43064.1 - 0.00023 21.1 0.7 0.00051 20.0 0.7 1.5 1 0 0 1 1 1 1 TMEM154 protein family Ig_2 PF13895.6 PIK43064.1 - 0.0015 18.8 0.1 0.0015 18.8 0.1 2.2 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK43064.1 - 0.021 15.4 1.3 0.041 14.5 0.1 2.2 2 0 0 2 2 2 0 Immunoglobulin domain EphA2_TM PF14575.6 PIK43064.1 - 0.039 14.8 0.0 0.11 13.4 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain V-set PF07686.17 PIK43064.1 - 0.091 12.9 1.4 0.47 10.7 0.4 2.6 2 1 1 3 3 3 0 Immunoglobulin V-set domain Phageshock_PspG PF09583.10 PIK43064.1 - 1.2 9.5 6.3 2 8.7 6.3 1.3 1 0 0 1 1 1 0 Phage shock protein G (Phageshock_PspG) TMEM154 PF15102.6 PIK43065.1 - 0.00039 20.4 2.4 0.00045 20.1 0.7 2.0 2 0 0 2 2 2 1 TMEM154 protein family Syndecan PF01034.20 PIK43065.1 - 0.0004 20.2 0.1 0.00079 19.3 0.1 1.5 1 0 0 1 1 1 1 Syndecan domain Ig_2 PF13895.6 PIK43065.1 - 0.00061 20.1 0.0 0.0018 18.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Cadherin_C_2 PF16492.5 PIK43065.1 - 0.003 18.3 0.0 0.009 16.7 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Mid2 PF04478.12 PIK43065.1 - 0.0036 17.2 0.1 0.0075 16.1 0.1 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Tmemb_9 PF05434.11 PIK43065.1 - 0.0042 17.0 0.1 0.009 15.9 0.1 1.6 1 0 0 1 1 1 1 TMEM9 EphA2_TM PF14575.6 PIK43065.1 - 0.011 16.6 0.1 0.025 15.5 0.1 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_3 PF13927.6 PIK43065.1 - 0.015 15.9 0.2 0.085 13.5 0.0 2.4 2 0 0 2 2 1 0 Immunoglobulin domain DUF4834 PF16118.5 PIK43065.1 - 0.032 15.2 0.5 0.093 13.7 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Rax2 PF12768.7 PIK43065.1 - 0.039 13.4 0.1 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Sigma_reg_N PF13800.6 PIK43065.1 - 0.16 12.3 4.0 3.3 8.1 0.4 3.8 4 1 0 4 4 4 0 Sigma factor regulator N-terminal MAP17 PF15807.5 PIK43065.1 - 0.22 11.7 0.4 0.45 10.8 0.1 1.7 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 I-set PF07679.16 PIK43065.1 - 0.56 10.3 4.4 1.1 9.3 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK43066.1 - 0.00061 20.1 0.1 0.00061 20.1 0.1 2.3 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK43066.1 - 0.0023 18.5 0.7 0.014 16.0 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.6 PIK43066.1 - 0.012 15.5 5.0 0.021 14.7 4.6 1.7 1 1 0 1 1 1 0 TMEM154 protein family RIFIN PF02009.16 PIK43066.1 - 0.03 14.2 0.4 0.056 13.3 0.4 1.5 1 0 0 1 1 1 0 Rifin EphA2_TM PF14575.6 PIK43066.1 - 0.081 13.8 0.0 0.22 12.4 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 PIK43066.1 - 0.21 12.6 1.2 0.72 10.9 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Shisa PF13908.6 PIK43066.1 - 0.26 11.5 6.8 0.037 14.3 2.6 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator PAG PF15347.6 PIK43067.1 - 0.0063 15.6 0.3 0.0063 15.6 0.3 2.1 2 0 0 2 2 2 1 Phosphoprotein associated with glycosphingolipid-enriched DUF5527 PF17665.1 PIK43067.1 - 0.042 13.4 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5527) TMEM154 PF15102.6 PIK43067.1 - 0.11 12.4 0.2 0.29 11.0 0.2 1.7 1 0 0 1 1 1 0 TMEM154 protein family Shisa PF13908.6 PIK43068.1 - 0.00028 21.2 1.0 0.00055 20.2 1.0 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Stevor PF17410.2 PIK43068.1 - 0.0084 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame ODV-E18 PF10717.9 PIK43068.1 - 0.011 15.6 0.9 0.028 14.3 0.9 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 RIFIN PF02009.16 PIK43068.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Rifin DUF3169 PF11368.8 PIK43068.1 - 0.019 14.5 0.1 0.066 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Tmemb_9 PF05434.11 PIK43068.1 - 0.021 14.7 2.2 0.034 14.1 0.7 2.2 2 1 0 2 2 2 0 TMEM9 Ig_2 PF13895.6 PIK43068.1 - 0.038 14.3 1.3 0.22 11.9 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain EphA2_TM PF14575.6 PIK43068.1 - 0.048 14.5 0.0 0.1 13.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK43068.1 - 0.11 12.4 5.2 0.058 13.3 1.8 2.1 1 1 1 2 2 2 0 TMEM154 protein family DUF4834 PF16118.5 PIK43068.1 - 0.11 13.4 0.4 0.24 12.4 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM132D_C PF15706.5 PIK43068.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ig_3 PF13927.6 PIK43068.1 - 0.15 12.6 2.4 0.25 12.0 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin domain Shisa PF13908.6 PIK43069.1 - 4.4e-05 23.8 0.2 9.4e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK43069.1 - 0.00025 21.0 0.4 0.00025 21.0 0.4 2.2 1 1 1 2 2 2 1 TMEM154 protein family RIFIN PF02009.16 PIK43069.1 - 0.0094 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Rifin Ig_3 PF13927.6 PIK43069.1 - 0.016 15.8 0.7 0.41 11.3 0.0 3.2 2 0 0 2 2 2 0 Immunoglobulin domain EphA2_TM PF14575.6 PIK43069.1 - 0.047 14.6 0.0 0.13 13.1 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 PIK43069.1 - 0.049 13.5 1.8 0.068 13.0 0.1 1.9 1 1 0 2 2 2 0 Transmembrane protein 51 Tmemb_9 PF05434.11 PIK43069.1 - 0.095 12.6 1.8 0.14 12.0 0.0 2.2 3 0 0 3 3 3 0 TMEM9 DUF3377 PF11857.8 PIK43069.1 - 0.13 12.2 1.2 0.45 10.5 1.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Orf78 PF06024.12 PIK43069.1 - 0.15 12.3 0.3 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 Orf78 (ac78) RCR PF12273.8 PIK43069.1 - 0.17 12.6 0.0 0.41 11.3 0.0 1.7 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red NB PF04159.13 PIK43069.1 - 0.21 11.7 3.4 0.48 10.5 3.4 1.5 1 0 0 1 1 1 0 NB glycoprotein DUF4834 PF16118.5 PIK43069.1 - 0.21 12.5 0.0 0.21 12.5 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Insulin_TMD PF17870.1 PIK43069.1 - 0.61 10.2 4.7 1.5 9.0 4.7 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment TMEM164 PF14808.6 PIK43070.1 - 7.8e-102 340.0 9.0 9.3e-102 339.7 9.0 1.0 1 0 0 1 1 1 1 TMEM164 family NHL PF01436.21 PIK43071.1 - 8.6e-17 60.2 1.1 2.8e-06 27.1 0.1 3.7 3 0 0 3 3 3 2 NHL repeat zf-B_box PF00643.24 PIK43071.1 - 5.9e-15 55.1 27.3 4.1e-10 39.7 3.1 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-C3HC4_2 PF13923.6 PIK43071.1 - 3.8e-08 33.0 9.4 3.8e-08 33.0 9.4 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK43071.1 - 3.8e-08 33.5 8.2 3.8e-08 33.5 8.2 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 PIK43071.1 - 6.6e-08 32.3 7.3 6.6e-08 32.3 7.3 3.2 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK43071.1 - 8.4e-08 32.1 7.0 8.4e-08 32.1 7.0 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK43071.1 - 8.5e-08 32.2 8.6 8.5e-08 32.2 8.6 3.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK43071.1 - 2.3e-07 30.5 4.8 2.3e-07 30.5 4.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK43071.1 - 3.3e-07 30.1 6.3 3.3e-07 30.1 6.3 3.4 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 SGL PF08450.12 PIK43071.1 - 4.7e-07 29.6 0.0 0.004 16.8 0.0 2.4 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Filamin PF00630.19 PIK43071.1 - 6.7e-05 23.6 0.0 0.00019 22.2 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-RING_5 PF14634.6 PIK43071.1 - 7.5e-05 22.6 7.5 7.5e-05 22.6 7.5 3.8 3 1 0 3 3 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK43071.1 - 0.0015 18.5 2.7 0.0055 16.7 2.7 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 PIK43071.1 - 0.0033 17.7 4.6 0.0033 17.7 4.6 3.3 3 0 0 3 3 2 1 RING-H2 zinc finger domain DUF5128 PF17170.4 PIK43071.1 - 0.015 14.5 0.0 0.17 11.0 0.0 2.4 2 0 0 2 2 2 0 6-bladed beta-propeller zf-RING_6 PF14835.6 PIK43071.1 - 0.017 15.0 2.0 0.08 12.8 2.0 2.2 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Arylesterase PF01731.20 PIK43071.1 - 0.069 13.3 0.0 6.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Arylesterase Invasin_D3 PF09134.10 PIK43071.1 - 0.08 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Invasin, domain 3 Phage_Mu_Gam PF07352.12 PIK43071.1 - 0.15 12.0 1.6 0.42 10.5 1.6 1.8 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein zf-UDP PF14569.6 PIK43071.1 - 1 9.5 11.2 1.1 9.4 0.2 3.3 3 0 0 3 3 3 0 Zinc-binding RING-finger CENP-F_leu_zip PF10473.9 PIK43071.1 - 2.5 8.1 8.7 4.6 7.3 8.7 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Trm112p PF03966.16 PIK43071.1 - 5.4 7.7 8.2 31 5.3 2.4 3.2 4 0 0 4 4 2 0 Trm112p-like protein DUF4690 PF15756.5 PIK43072.1 - 0.37 11.4 2.0 0.4 11.3 0.4 1.8 2 0 0 2 2 2 0 Small Novel Rich in Cartilage DUF4994 PF16385.5 PIK43073.1 - 2.9e-06 27.1 1.3 7.4 6.6 0.0 6.6 1 1 6 8 8 8 2 Domain of unknown function Reductase_C PF14759.6 PIK43073.1 - 7.1e-05 23.3 1.8 1.2e+02 3.3 0.0 7.5 1 1 6 9 9 9 0 Reductase C-terminal TTL PF03133.15 PIK43073.1 - 2.8 7.0 7.9 5.9 5.9 0.3 4.0 3 3 2 5 5 5 0 Tubulin-tyrosine ligase family Mucin-like PF16058.5 PIK43073.1 - 5.3 7.2 55.9 1.2e+02 2.8 16.4 4.8 1 1 2 3 3 3 0 Mucin-like Jiraiya PF15038.6 PIK43074.1 - 0.0062 16.0 0.5 0.009 15.5 0.5 1.2 1 0 0 1 1 1 1 Jiraiya C12orf66_like PF09404.10 PIK43075.1 - 7.7e-113 377.6 7.1 2.9e-112 375.7 7.1 1.7 1 1 0 1 1 1 1 KICSTOR complex C12orf66 like Prominin PF05478.11 PIK43076.1 - 0.0047 15.0 5.1 0.0067 14.5 5.1 1.1 1 0 0 1 1 1 1 Prominin DUF5344 PF17279.2 PIK43076.1 - 0.028 15.0 1.3 0.05 14.2 0.7 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5344) APG6_N PF17675.1 PIK43076.1 - 0.058 13.9 13.6 0.13 12.8 13.6 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF643 PF04867.12 PIK43076.1 - 0.47 11.1 5.1 1.2 9.7 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF643) ERM PF00769.19 PIK43076.1 - 0.57 10.0 13.2 0.14 12.0 10.0 1.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Gluconate_2-dh3 PF13618.6 PIK43076.1 - 0.73 10.1 2.7 0.88 9.8 2.6 1.3 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 TFR_dimer PF04253.15 PIK43076.1 - 2.6 8.2 6.9 1.3 9.2 1.2 2.6 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain VPS13_mid_rpt PF16910.5 PIK43077.1 - 0.083 12.3 0.3 1.5 8.2 0.0 2.7 3 0 0 3 3 3 0 Repeating coiled region of VPS13 MAP17 PF15807.5 PIK43077.1 - 8.1 6.7 7.6 1.3 9.3 0.2 2.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 VPS13_mid_rpt PF16910.5 PIK43078.1 - 2.5e-61 207.1 0.2 8.3e-60 202.1 0.0 2.9 3 0 0 3 3 3 1 Repeating coiled region of VPS13 REC1 PF18501.1 PIK43078.1 - 0.064 13.1 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Alpha helical recognition lobe domain BUD22 PF09073.10 PIK43078.1 - 0.29 10.4 20.6 0.69 9.2 20.6 1.7 1 0 0 1 1 1 0 BUD22 Nucleo_P87 PF07267.11 PIK43078.1 - 7.2 5.3 11.5 12 4.6 11.5 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 VPS13 PF16908.5 PIK43079.1 - 4.9e-72 242.5 3.0 4.9e-72 242.5 3.0 1.5 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal DUF2076 PF09849.9 PIK43079.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Gemini_AL3 PF01407.17 PIK43079.1 - 0.16 11.8 0.7 0.42 10.5 0.0 2.0 3 0 0 3 3 3 0 Geminivirus AL3 protein DUF5629 PF18629.1 PIK43079.1 - 0.87 10.2 3.0 0.62 10.6 0.9 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5629) Ras PF00071.22 PIK43080.1 - 1.1e-42 145.5 0.7 1.2e-42 145.2 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK43080.1 - 7.8e-13 48.7 0.1 1.4e-12 47.8 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43080.1 - 7.9e-06 25.4 0.1 9.4e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK43080.1 - 3.1e-05 23.6 0.3 5.7e-05 22.7 0.3 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 PIK43080.1 - 8.1e-05 22.5 0.1 0.0001 22.2 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 PIK43080.1 - 0.0031 17.4 0.1 0.0055 16.6 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 PIK43080.1 - 0.01 15.3 0.3 0.09 12.3 0.3 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF1160 PF06648.11 PIK43081.1 - 0.08 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) Lectin_C PF00059.21 PIK43084.1 - 2.8e-16 60.2 1.6 6.1e-16 59.1 1.6 1.5 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK43084.1 - 0.074 12.7 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like YL1 PF05764.13 PIK43085.1 - 3.8e-41 141.8 26.1 3.8e-41 141.8 26.1 1.5 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 PIK43085.1 - 3.7e-12 45.8 1.7 7.4e-12 44.8 1.7 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Acyl-CoA_dh_1 PF00441.24 PIK43086.1 - 1.1e-43 149.1 0.0 2.2e-43 148.0 0.0 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK43086.1 - 1.9e-27 96.1 0.0 3.6e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK43086.1 - 1.1e-22 80.0 0.1 1.8e-22 79.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK43086.1 - 8.6e-14 52.0 0.0 1.9e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 PIK43086.1 - 0.022 14.4 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 PIK43087.1 - 4.8e-37 127.5 0.0 2.3e-36 125.3 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK43087.1 - 1.4e-21 77.3 0.0 3.7e-21 75.9 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK43087.1 - 4e-12 46.6 0.0 4.9e-11 43.0 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK43087.1 - 4.2e-09 36.5 0.0 6.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain EGF PF00008.27 PIK43090.1 - 8e-88 288.2 213.4 1.4e-09 38.1 3.4 15.3 15 0 0 15 15 15 14 EGF-like domain hEGF PF12661.7 PIK43090.1 - 3.7e-54 179.6 194.3 6.4e-06 26.6 4.8 17.1 17 0 0 17 17 17 14 Human growth factor-like EGF EGF_CA PF07645.15 PIK43090.1 - 7.1e-34 115.7 202.6 5.1e-07 29.8 8.5 15.4 12 3 3 15 15 15 12 Calcium-binding EGF domain EGF_2 PF07974.13 PIK43090.1 - 1.6e-12 47.6 233.8 0.0014 19.0 4.6 15.0 14 1 1 15 15 15 11 EGF-like domain FXa_inhibition PF14670.6 PIK43090.1 - 4.8e-05 23.6 185.8 0.21 11.9 3.7 15.4 8 4 7 15 15 15 8 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK43090.1 - 0.39 10.9 199.5 0.054 13.7 3.6 15.9 15 1 0 15 15 15 0 EGF domain EGF PF00008.27 PIK43091.1 - 2.7e-28 97.9 44.3 5.8e-08 32.9 3.3 4.3 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK43091.1 - 3.3e-20 71.9 48.9 4.2e-07 30.4 3.1 5.9 6 1 1 7 7 7 4 Human growth factor-like EGF EGF_3 PF12947.7 PIK43091.1 - 8.3e-14 51.5 45.6 0.0001 22.4 5.9 4.7 2 1 2 4 4 4 4 EGF domain EGF_CA PF07645.15 PIK43091.1 - 2e-11 43.9 51.6 8.3e-05 22.7 5.4 4.2 3 1 1 4 4 4 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK43091.1 - 1.1e-09 38.4 52.4 0.00041 20.7 6.8 4.2 4 0 0 4 4 4 4 EGF-like domain FXa_inhibition PF14670.6 PIK43091.1 - 2.1e-08 34.3 40.6 0.015 15.6 5.5 4.5 2 1 2 4 4 4 4 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 PIK43091.1 - 0.0012 18.9 44.1 1.1 9.4 5.2 4.3 1 1 3 4 4 4 2 Laminin EGF domain EGF_MSP1_1 PF12946.7 PIK43091.1 - 0.0027 17.7 7.6 0.0027 17.7 7.6 4.4 4 1 0 4 4 4 2 MSP1 EGF domain 1 EGF PF00008.27 PIK43092.1 - 1.7e-21 76.2 50.3 1.6e-09 37.9 6.5 5.7 4 1 0 4 4 4 3 EGF-like domain hEGF PF12661.7 PIK43092.1 - 3e-15 56.2 40.3 5.4e-06 26.8 3.4 5.8 5 0 0 5 5 5 3 Human growth factor-like EGF DSL PF01414.19 PIK43092.1 - 6.2e-14 52.0 7.8 6.2e-14 52.0 7.8 3.9 3 1 2 5 5 5 1 Delta serrate ligand MNNL PF07657.13 PIK43092.1 - 1.3e-08 34.8 1.4 1.3e-08 34.8 1.4 4.2 3 1 2 5 5 5 1 N terminus of Notch ligand EGF_CA PF07645.15 PIK43092.1 - 1.8e-05 24.9 17.8 0.00011 22.3 1.9 5.4 5 1 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.7 PIK43092.1 - 0.00016 21.5 30.6 0.018 15.0 2.3 5.8 5 0 0 5 5 5 4 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK43092.1 - 0.013 15.9 59.5 0.53 10.7 10.8 6.2 5 0 0 5 5 5 0 EGF-like domain Totivirus_coat PF05518.11 PIK43093.1 - 0.086 10.9 2.8 0.1 10.6 2.8 1.1 1 0 0 1 1 1 0 Totivirus coat protein Peptidase_S49_N PF08496.10 PIK43093.1 - 5.2 7.1 6.1 2 8.5 3.5 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PKD PF00801.20 PIK43095.1 - 7.6e-51 169.9 45.2 3.3e-11 42.9 2.0 10.0 10 2 0 10 10 10 6 PKD domain REJ PF02010.15 PIK43095.1 - 4.2e-37 128.0 1.0 4.2e-37 128.0 1.0 2.3 2 0 0 2 2 2 1 REJ domain PKD PF00801.20 PIK43096.1 - 6.3e-11 42.0 2.2 3e-05 23.8 0.1 2.4 2 0 0 2 2 2 2 PKD domain PKD_3 PF16820.5 PIK43096.1 - 0.15 11.8 0.1 5.8 6.7 0.0 2.3 2 0 0 2 2 2 0 PKD-like domain Fringe PF02434.16 PIK43097.1 - 3.4e-12 46.3 0.1 1.6e-11 44.1 0.1 2.1 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 PIK43097.1 - 0.0023 17.8 0.5 0.045 13.6 0.0 2.7 2 1 0 2 2 2 1 Galactosyltransferase RNA_polI_A34 PF08208.11 PIK43097.1 - 0.068 13.3 8.9 0.13 12.3 8.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Ras PF00071.22 PIK43098.1 - 1.7e-41 141.5 0.1 3.5e-32 111.2 0.0 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK43098.1 - 1.6e-29 102.5 0.0 2.1e-29 102.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43098.1 - 8.9e-12 44.8 0.1 4e-10 39.4 0.0 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK43098.1 - 2.2e-06 27.7 0.0 2.6e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK43098.1 - 0.00014 21.3 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK43098.1 - 0.00021 20.9 0.1 0.0058 16.2 0.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 PIK43098.1 - 0.00068 19.4 0.1 0.0012 18.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK43098.1 - 0.0013 19.0 0.0 0.0044 17.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 PIK43098.1 - 0.0014 18.1 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 PIK43098.1 - 0.0035 17.7 0.1 0.0059 17.0 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 PIK43098.1 - 0.0068 16.3 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 PIK43098.1 - 0.016 14.9 0.3 0.037 13.8 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 PIK43098.1 - 0.026 15.1 0.1 0.031 14.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 PIK43098.1 - 0.03 13.8 0.0 0.058 12.9 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 PIK43098.1 - 0.038 13.8 0.1 0.37 10.5 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 PIK43098.1 - 0.053 12.8 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 Septin Hpr_kinase_C PF07475.12 PIK43098.1 - 0.063 12.8 0.2 0.21 11.1 0.1 1.8 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain NACHT PF05729.12 PIK43098.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 NACHT domain MCM PF00493.23 PIK43098.1 - 0.088 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain TniB PF05621.11 PIK43098.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_5 PF07728.14 PIK43098.1 - 0.17 11.9 0.0 0.23 11.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 PIK43098.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain HLH PF00010.26 PIK43099.1 - 4.9e-19 68.0 0.3 8.9e-19 67.2 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF716 PF04819.12 PIK43100.1 - 1.4e-08 34.4 2.1 3e-08 33.4 2.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) SPC12 PF06645.13 PIK43100.1 - 3.3 7.8 7.3 1.4 9.0 0.1 2.7 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) SQHop_cyclase_C PF13243.6 PIK43101.1 - 6.2e-45 153.7 0.3 1.1e-44 152.9 0.3 1.3 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 PIK43101.1 - 5.2e-36 124.2 0.3 7.6e-30 104.0 0.0 4.2 4 1 1 5 5 5 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 PIK43101.1 - 2.7e-24 84.6 7.2 7.4e-12 44.8 0.4 5.2 5 1 0 5 5 5 2 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 PIK43101.1 - 0.0069 15.5 0.0 1.7 7.6 0.0 3.0 3 1 1 4 4 4 2 A-macroglobulin TED domain Pec_lyase PF09492.10 PIK43101.1 - 0.015 14.6 0.1 15 4.8 0.0 4.0 3 1 1 4 4 4 0 Pectic acid lyase SQHop_cyclase_C PF13243.6 PIK43102.1 - 3.8e-35 121.5 0.1 6.5e-35 120.8 0.1 1.3 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 PIK43102.1 - 5e-21 74.1 6.3 1.3e-09 37.6 1.0 3.6 3 1 0 3 3 3 2 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 PIK43102.1 - 0.0054 15.9 0.0 0.77 8.8 0.0 3.0 3 0 0 3 3 3 2 Squalene-hopene cyclase N-terminal domain GIY-YIG PF01541.24 PIK43103.1 - 5e-05 23.5 0.1 0.00011 22.4 0.1 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK43103.1 - 0.00046 19.8 0.0 0.00082 19.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK43104.1 - 4.3e-16 59.0 3.4 4.8e-16 58.9 3.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43104.1 - 0.006 16.0 3.2 0.0076 15.7 3.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK43104.1 - 0.0077 15.6 2.4 0.0096 15.3 2.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Sulf_transp PF04143.14 PIK43104.1 - 0.095 12.2 0.2 0.11 12.1 0.2 1.1 1 0 0 1 1 1 0 Sulphur transport 7tm_1 PF00001.21 PIK43105.1 - 1.3e-16 60.8 3.5 1.5e-16 60.6 3.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43105.1 - 0.004 16.6 2.7 0.0051 16.2 2.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_7 PF08395.12 PIK43105.1 - 0.067 12.4 4.5 0.081 12.1 4.0 1.3 1 1 0 1 1 1 0 7tm Chemosensory receptor Sulf_transp PF04143.14 PIK43105.1 - 0.11 12.0 0.2 0.12 11.9 0.2 1.1 1 0 0 1 1 1 0 Sulphur transport 7tm_1 PF00001.21 PIK43106.1 - 9.9e-40 136.5 19.9 9.9e-40 136.5 19.9 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK43106.1 - 3.8e-11 43.1 19.5 3.8e-11 43.1 19.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK43106.1 - 4.2e-10 39.4 20.7 5.9e-10 39.0 20.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK43106.1 - 4.3e-06 26.7 13.9 6.8e-05 22.7 13.9 2.1 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK43106.1 - 9.9e-06 25.3 14.9 9.9e-06 25.3 14.9 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc zf-CCHC PF00098.23 PIK43108.1 - 4.7e-07 29.6 1.9 8.5e-07 28.8 1.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43108.1 - 0.00035 20.3 0.5 0.00071 19.3 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 PIK43108.1 - 0.00051 20.4 0.2 0.00074 19.9 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G GAGA PF09237.11 PIK43108.1 - 0.023 14.5 0.6 0.054 13.3 0.1 2.0 2 0 0 2 2 2 0 GAGA factor zf-CCHC_3 PF13917.6 PIK43108.1 - 0.062 13.3 1.0 0.062 13.3 1.0 2.1 1 1 1 2 2 2 0 Zinc knuckle 7tm_1 PF00001.21 PIK43109.1 - 8.4e-26 90.9 10.0 9.6e-26 90.7 10.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK43109.1 - 6.4e-07 29.3 5.8 6.4e-07 29.3 5.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK43109.1 - 8.6e-07 28.6 10.4 1.1e-06 28.2 10.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK43109.1 - 2.9e-06 26.9 8.2 3.7e-06 26.5 8.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK43109.1 - 3.6e-06 26.9 5.0 0.00016 21.5 5.0 2.1 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK43109.1 - 0.017 14.6 1.3 0.017 14.6 1.3 1.9 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_1 PF00001.21 PIK43110.1 - 1.4e-40 139.3 19.2 1.4e-40 139.3 19.2 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43110.1 - 7.4e-11 41.9 20.4 1.1e-10 41.4 20.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK43110.1 - 3.8e-09 36.5 19.3 3.8e-09 36.5 19.3 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK43110.1 - 8.3e-08 32.3 12.2 6.7e-05 22.8 5.7 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK43110.1 - 3.9e-05 23.3 14.4 3.9e-05 23.3 14.4 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc Yip1 PF04893.17 PIK43110.1 - 1.8 8.2 15.1 0.095 12.4 7.4 2.3 1 1 1 2 2 2 0 Yip1 domain Sm_multidrug_ex PF06695.11 PIK43110.1 - 6.6 7.4 8.8 4.3 8.0 2.2 2.9 2 1 1 3 3 3 0 Putative small multi-drug export protein ELYS-bb PF16687.5 PIK43112.1 - 1.4e-58 198.7 1.7 8.7e-31 107.1 0.3 2.5 1 1 1 2 2 2 2 beta-propeller of ELYS nucleoporin ELYS PF13934.6 PIK43112.1 - 1.4e-23 84.0 0.1 4.5e-23 82.4 0.1 1.8 1 1 1 2 2 2 1 Nuclear pore complex assembly CesT PF05932.13 PIK43112.1 - 0.14 12.3 0.7 0.41 10.8 0.0 2.2 2 0 0 2 2 2 0 Tir chaperone protein (CesT) family Optomotor-blind PF11078.8 PIK43112.1 - 0.3 11.7 1.4 0.73 10.4 1.4 1.6 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region PH PF00169.29 PIK43116.1 - 3.1e-05 24.4 0.1 3.1e-05 24.4 0.1 3.3 3 2 0 3 3 3 2 PH domain PH_9 PF15410.6 PIK43116.1 - 0.066 13.6 0.4 7.2 7.0 0.0 3.6 3 1 0 3 3 3 0 Pleckstrin homology domain DUF2570 PF10828.8 PIK43116.1 - 0.21 11.4 1.8 0.53 10.1 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) CCDC50_N PF15295.6 PIK43117.1 - 9.6e-12 45.2 44.0 6.3e-11 42.5 24.9 3.3 2 1 1 3 3 3 2 Coiled-coil domain-containing protein 50 N-terminus Pantoate_ligase PF02569.15 PIK43117.1 - 0.03 13.5 7.2 0.044 13.0 7.2 1.4 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase DUF3500 PF12006.8 PIK43117.1 - 0.86 9.0 6.7 1.4 8.4 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) Trehalase PF01204.18 PIK43117.1 - 2.5 6.8 11.0 3.8 6.2 11.0 1.3 1 0 0 1 1 1 0 Trehalase PH PF00169.29 PIK43118.1 - 1.3e-20 73.9 2.1 5.3e-09 36.5 0.0 3.0 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 PIK43118.1 - 0.00028 20.7 0.6 0.43 10.4 0.3 2.8 2 0 0 2 2 2 2 Pleckstrin homology domain DUF4485 PF14846.6 PIK43118.1 - 0.054 13.6 0.4 0.17 12.0 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Pox_A_type_inc PF04508.12 PIK43118.1 - 1 9.4 3.4 0.97 9.4 0.2 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat GHMP_kinases_N PF00288.26 PIK43119.1 - 7.4e-07 29.3 0.0 1.4e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 PIK43119.1 - 2.4e-06 27.8 0.0 4.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal NTP_transferase PF00483.23 PIK43119.1 - 0.0005 19.7 0.0 0.71 9.4 0.0 2.3 1 1 1 2 2 2 2 Nucleotidyl transferase TPR_1 PF00515.28 PIK43120.1 - 1.2e-17 62.9 0.4 3.4e-08 32.9 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43120.1 - 7.2e-15 53.8 0.6 7.2e-06 25.7 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43120.1 - 5.5e-11 42.8 7.5 2.1e-05 25.0 0.3 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43120.1 - 7.5e-09 35.1 2.3 0.00023 21.1 0.0 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43120.1 - 9.5e-08 32.3 0.1 0.29 12.1 0.0 4.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43120.1 - 3.5e-06 27.6 0.8 0.0022 18.6 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43120.1 - 3.5e-06 26.6 1.4 0.14 11.8 0.1 3.5 1 1 2 3 3 3 2 TPR repeat TPR_12 PF13424.6 PIK43120.1 - 1e-05 25.7 4.6 0.034 14.4 2.2 3.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43120.1 - 1.7e-05 24.5 0.9 0.24 11.5 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43120.1 - 4.5e-05 23.6 4.2 0.0004 20.5 2.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 PIK43120.1 - 0.0004 20.0 0.1 0.0016 18.1 0.1 2.0 2 0 0 2 2 1 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_17 PF13431.6 PIK43120.1 - 0.00042 20.5 0.6 0.66 10.5 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 PIK43120.1 - 0.0014 18.7 5.5 0.039 14.0 0.2 4.2 4 1 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 PIK43120.1 - 0.0036 17.9 2.6 1 10.1 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK43120.1 - 0.026 14.4 1.4 0.68 9.9 0.5 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43120.1 - 0.029 14.5 0.0 0.087 13.0 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat HemY_N PF07219.13 PIK43120.1 - 0.047 13.9 0.5 0.13 12.4 0.5 1.7 1 0 0 1 1 1 0 HemY protein N-terminus Rnk_N PF14760.6 PIK43120.1 - 0.052 14.0 0.3 23 5.6 0.0 3.3 3 0 0 3 3 3 0 Rnk N-terminus CvfB_WH PF17783.1 PIK43120.1 - 0.069 13.0 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 CvfB-like winged helix domain Egg_lysin PF01303.17 PIK43120.1 - 0.12 12.6 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) Homeodomain PF00046.29 PIK43121.1 - 1.4e-16 60.1 1.0 2.2e-16 59.4 1.0 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 PIK43121.1 - 0.028 13.9 0.3 0.065 12.7 0.3 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 PIK43121.1 - 0.033 14.1 0.1 0.056 13.4 0.1 1.4 1 0 0 1 1 1 0 Homeobox KN domain WD40 PF00400.32 PIK43122.1 - 8.5e-22 77.1 29.0 0.00028 21.6 0.6 9.7 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43122.1 - 0.021 15.1 1.0 6.2 7.2 0.0 4.4 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Pentaxin PF00354.17 PIK43122.1 - 0.14 11.8 0.6 0.33 10.6 0.1 1.9 2 0 0 2 2 2 0 Pentaxin family IQ PF00612.27 PIK43123.1 - 3.5e-17 60.5 6.3 1.7e-05 24.2 0.1 3.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif RIIa PF02197.17 PIK43123.1 - 6.7e-12 44.9 0.1 1.1e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit RsbRD_N PF14361.6 PIK43123.1 - 0.068 13.9 1.0 0.26 12.0 0.0 2.2 2 1 1 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain EBV-NA3 PF05009.12 PIK43123.1 - 0.17 11.4 3.2 0.23 11.0 3.2 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF4661 PF15576.6 PIK43123.1 - 0.45 10.4 5.2 0.6 10.0 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) IQ PF00612.27 PIK43124.1 - 2.8e-13 48.4 2.4 0.00013 21.4 0.0 3.2 3 0 0 3 3 3 3 IQ calmodulin-binding motif Ig_2 PF13895.6 PIK43125.1 - 4.8e-05 23.6 0.3 0.0013 19.0 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Shisa PF13908.6 PIK43125.1 - 4.9e-05 23.6 0.1 9.6e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FAM176 PF14851.6 PIK43125.1 - 7.7e-05 22.4 0.0 0.076 12.7 0.0 2.3 2 0 0 2 2 2 2 FAM176 family TMEM154 PF15102.6 PIK43125.1 - 0.0008 19.3 0.2 0.0021 18.0 0.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK43125.1 - 0.0014 18.2 0.2 0.0025 17.3 0.2 1.4 1 0 0 1 1 1 1 Baculovirus 11 kDa family ig PF00047.25 PIK43125.1 - 0.0023 18.1 1.9 0.082 13.1 0.7 2.9 2 0 0 2 2 2 1 Immunoglobulin domain Cadherin_C_2 PF16492.5 PIK43125.1 - 0.018 15.7 0.0 0.044 14.5 0.0 1.7 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal CEND1 PF15677.5 PIK43125.1 - 0.031 14.8 0.0 0.074 13.6 0.0 1.6 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 RIFIN PF02009.16 PIK43125.1 - 0.035 14.0 0.0 0.065 13.1 0.0 1.5 1 1 0 1 1 1 0 Rifin EphA2_TM PF14575.6 PIK43125.1 - 0.045 14.6 0.0 0.14 13.1 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Orthoreo_P10 PF07204.11 PIK43125.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 C2-set_2 PF08205.12 PIK43125.1 - 1.3 9.1 5.7 0.45 10.6 0.2 3.0 3 1 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Pkinase PF00069.25 PIK43126.1 - 9e-74 248.2 0.0 1.2e-73 247.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43126.1 - 3.3e-35 121.6 0.0 5.2e-35 121.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Anoct_dimer PF16178.5 PIK43126.1 - 0.0022 17.8 0.5 0.0044 16.8 0.5 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Kinase-like PF14531.6 PIK43126.1 - 0.017 14.4 0.0 0.033 13.5 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 PIK43126.1 - 0.021 13.8 0.1 0.049 12.6 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Ntox3 PF15536.6 PIK43126.1 - 0.13 12.3 0.0 0.64 10.1 0.0 2.1 2 1 0 2 2 2 0 Bacterial toxin 3 MBT PF02820.18 PIK43127.1 - 1.2e-22 80.1 4.3 2.8e-17 62.8 1.0 2.6 2 0 0 2 2 2 2 mbt repeat zf-C2HC PF01530.18 PIK43127.1 - 2e-16 59.9 22.8 3.9e-13 49.3 10.3 2.7 3 0 0 3 3 3 2 Zinc finger, C2HC type MBT PF02820.18 PIK43128.1 - 3.9e-21 75.2 0.0 6.5e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 mbt repeat zf-FCS PF06467.14 PIK43128.1 - 0.21 11.6 4.9 2.6 8.1 4.9 2.5 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif PCMT PF01135.19 PIK43129.1 - 1.8e-16 60.5 0.0 3.2e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 PIK43129.1 - 6.3e-06 26.1 0.0 2e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 PIK43129.1 - 0.00063 19.3 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 SOCS_box PF07525.16 PIK43129.1 - 0.055 13.8 6.6 0.97 9.8 0.6 2.4 2 0 0 2 2 2 0 SOCS box zf-C2HC PF01530.18 PIK43130.1 - 1.1e-80 265.3 82.3 7.4e-15 54.8 6.6 6.5 6 0 0 6 6 6 6 Zinc finger, C2HC type MYT1 PF08474.11 PIK43130.1 - 5.9e-08 32.9 0.7 7.3e-06 26.1 0.7 2.4 1 1 0 1 1 1 1 Myelin transcription factor 1 WD40 PF00400.32 PIK43131.1 - 1.3e-11 44.8 3.9 1.1e-05 26.0 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat WD40 PF00400.32 PIK43132.1 - 2.1e-11 44.1 20.8 0.00017 22.3 0.0 7.0 8 0 0 8 8 8 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 PIK43132.1 - 4.2e-06 25.8 0.7 0.038 12.7 0.0 3.5 3 1 0 3 3 3 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 PIK43132.1 - 0.0016 18.7 0.5 0.44 10.9 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2052 PF09747.9 PIK43132.1 - 0.0089 16.2 18.7 0.0089 16.2 18.7 2.9 2 1 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) PRP38_assoc PF12871.7 PIK43132.1 - 7.1 7.3 67.5 1.3 9.6 6.4 4.3 4 0 0 4 4 4 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Utp12 PF04003.12 PIK43134.1 - 6e-16 58.7 2.0 1.3e-15 57.7 2.0 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 PIK43134.1 - 6.4e-08 33.1 5.1 0.0047 17.8 0.3 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43134.1 - 0.0044 17.3 0.0 0.028 14.7 0.0 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain PPP4R2 PF09184.11 PIK43134.1 - 2.6 7.6 16.7 6.6 6.2 16.7 1.7 1 0 0 1 1 1 0 PPP4R2 CIA30 PF08547.12 PIK43136.1 - 1e-43 149.2 0.1 1.4e-43 148.7 0.1 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.13 PIK43136.1 - 0.0011 18.9 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain (family 11) TauD PF02668.16 PIK43137.1 - 3.4e-34 118.8 0.1 4.5e-34 118.5 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 PIK43137.1 - 0.013 14.7 0.0 0.021 13.9 0.0 1.5 1 1 0 1 1 1 0 CsiD PIP49_C PF12260.8 PIK43139.1 - 0.023 14.3 0.0 0.05 13.2 0.0 1.5 1 1 0 1 1 1 0 Protein-kinase domain of FAM69 PH PF00169.29 PIK43140.1 - 6.3e-27 94.1 0.3 1.7e-13 50.9 0.0 2.5 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 PIK43140.1 - 1.5e-13 50.9 0.0 9.6e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 PIK43140.1 - 4.4e-12 46.0 0.2 2.2e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 PH domain ArfGap PF01412.18 PIK43140.1 - 2.1e-10 40.7 7.6 1.9e-08 34.4 6.2 3.3 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf PH_11 PF15413.6 PIK43140.1 - 5.9e-08 33.1 3.0 0.031 14.7 0.0 4.2 2 1 0 2 2 2 2 Pleckstrin homology domain UPA PF17217.3 PIK43140.1 - 0.0027 17.6 0.3 0.009 15.9 0.1 2.0 2 0 0 2 2 2 1 UPA domain PH_16 PF17838.1 PIK43140.1 - 0.023 14.5 0.0 4.8 7.0 0.0 2.5 2 0 0 2 2 2 0 PH domain FYVE_2 PF02318.16 PIK43140.1 - 0.032 14.4 3.9 0.097 12.9 3.9 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger PH_2 PF08458.10 PIK43140.1 - 0.14 12.6 0.0 0.79 10.1 0.0 2.1 2 0 0 2 2 2 0 Plant pleckstrin homology-like region Pkinase PF00069.25 PIK43142.1 - 4.2e-37 127.9 3.1 2.1e-36 125.6 0.1 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43142.1 - 6.5e-28 97.7 0.6 9.8e-28 97.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DED PF01335.21 PIK43142.1 - 1.9e-05 24.9 0.7 8.3e-05 22.8 0.7 2.2 1 0 0 1 1 1 1 Death effector domain Pkinase_fungal PF17667.1 PIK43142.1 - 2.5e-05 23.3 0.0 4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase ResIII PF04851.15 PIK43142.1 - 0.00023 21.2 0.0 0.00076 19.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-U1 PF06220.12 PIK43142.1 - 0.0011 18.7 0.7 0.0029 17.3 0.7 1.7 1 0 0 1 1 1 1 U1 zinc finger AAA_11 PF13086.6 PIK43142.1 - 0.0014 18.5 0.0 0.0041 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Kinase-like PF14531.6 PIK43142.1 - 0.013 14.8 0.1 0.16 11.2 0.0 2.2 2 0 0 2 2 2 0 Kinase-like AAA_19 PF13245.6 PIK43142.1 - 0.016 15.6 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Kdo PF06293.14 PIK43142.1 - 0.057 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sipho_Gp157 PF05565.11 PIK43142.1 - 0.25 11.4 4.4 0.81 9.7 0.4 3.3 3 0 0 3 3 3 0 Siphovirus Gp157 UvrD-helicase PF00580.21 PIK43142.1 - 0.32 10.5 0.0 0.32 10.5 0.0 2.8 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_11 PF13086.6 PIK43143.1 - 2e-13 50.8 0.5 3.9e-13 49.8 0.1 1.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK43143.1 - 4.7e-06 26.4 0.0 6.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK43143.1 - 0.00021 21.7 0.1 0.00033 21.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 PIK43143.1 - 0.0017 18.1 0.1 0.0027 17.5 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK43143.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 PIK43143.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.21 PIK43143.1 - 0.026 13.9 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK43143.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_12 PF13087.6 PIK43144.1 - 2.9e-25 89.0 0.4 1.8e-23 83.2 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.6 PIK43144.1 - 9.6e-25 87.8 2.5 1.1e-24 87.6 0.9 1.9 2 1 0 2 2 2 1 AAA domain UvrD_C PF13361.6 PIK43144.1 - 2.6e-08 33.6 0.5 6.6e-08 32.3 0.5 1.8 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 PIK43144.1 - 5e-05 23.1 0.0 0.00014 21.6 0.0 1.6 1 1 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 PIK43144.1 - 0.00032 20.5 0.0 0.0043 16.8 0.0 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain YscO-like PF16789.5 PIK43144.1 - 0.017 15.2 1.0 0.044 13.8 0.3 1.9 2 0 0 2 2 2 0 YscO-like protein HMG_box PF00505.19 PIK43144.1 - 0.082 13.3 0.2 0.35 11.3 0.1 2.1 2 0 0 2 2 2 0 HMG (high mobility group) box CHDNT PF08073.12 PIK43144.1 - 0.2 11.7 0.8 0.4 10.7 0.1 1.9 2 0 0 2 2 2 0 CHDNT (NUC034) domain V-set PF07686.17 PIK43145.1 - 1.4e-13 50.9 4.1 3.2e-07 30.5 0.5 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK43145.1 - 2.8e-10 40.6 6.6 3.1e-06 27.7 0.9 4.4 3 1 1 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK43145.1 - 3.9e-08 33.4 5.7 0.00033 20.8 0.2 4.0 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK43145.1 - 3.1e-06 27.4 10.0 0.00017 21.8 3.3 3.9 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK43145.1 - 7.5e-06 25.9 0.7 7.5e-06 25.9 0.7 2.8 3 1 1 4 4 4 1 Immunoglobulin I-set domain ICAM_N PF03921.14 PIK43145.1 - 0.0097 15.6 0.6 0.46 10.2 0.0 3.5 3 0 0 3 3 3 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_6 PF18452.1 PIK43145.1 - 0.021 14.4 0.0 0.17 11.5 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Amidohydro_1 PF01979.20 PIK43147.1 - 5.4e-18 65.4 1.0 9.7e-18 64.6 1.0 1.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK43147.1 - 7.6e-06 25.7 0.0 1.7e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 Amidohydrolase family Motile_Sperm PF00635.26 PIK43147.1 - 0.038 13.8 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Actin PF00022.19 PIK43148.1 - 1.2e-113 379.8 0.0 3.4e-87 292.7 0.0 2.0 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 PIK43148.1 - 0.00032 19.6 0.0 0.056 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein NACHT PF05729.12 PIK43149.1 - 1.3e-10 41.4 0.0 3.3e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK43149.1 - 0.00033 20.3 0.0 0.0016 18.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK43149.1 - 0.0035 17.7 0.1 1.2 9.5 0.0 3.3 4 0 0 4 4 4 1 RNA helicase Hairy_orange PF07527.13 PIK43149.1 - 0.053 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Hairy Orange DAP3 PF10236.9 PIK43149.1 - 0.083 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RVT_1 PF00078.27 PIK43150.1 - 0.013 15.0 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) MliC PF09864.9 PIK43154.1 - 0.18 11.8 1.3 0.33 10.9 0.2 1.8 1 1 1 2 2 2 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme RL10P_insert PF17777.1 PIK43155.1 - 7.8e-11 41.8 0.1 1.9e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 PIK43155.1 - 1.3e-06 28.5 0.0 2.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 BNIP3 PF06553.12 PIK43155.1 - 0.051 13.2 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 BNIP3 Ribosomal_60s PF00428.19 PIK43155.1 - 0.071 13.7 2.0 1.1 9.9 0.0 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein TIP120 PF08623.10 PIK43156.1 - 2.4e-65 219.4 0.9 2.4e-65 219.4 0.9 1.8 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 PIK43156.1 - 3e-08 33.3 0.1 1.7 9.1 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 PIK43156.1 - 1.6e-07 31.5 3.5 8.9e-05 22.6 0.2 3.0 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK43156.1 - 5.8e-07 29.8 0.0 0.0045 17.3 0.0 3.9 3 1 1 4 4 4 1 HEAT repeats Adaptin_N PF01602.20 PIK43156.1 - 3e-06 26.1 3.1 6.8e-05 21.6 0.5 2.4 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_EZ PF13513.6 PIK43156.1 - 0.0023 18.4 0.0 17 6.1 0.0 4.2 4 1 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 PIK43157.1 - 8.8e-15 54.9 0.1 0.0013 19.1 0.0 5.8 5 1 1 6 6 5 2 HEAT repeats HEAT PF02985.22 PIK43157.1 - 7.9e-11 41.3 5.7 0.04 14.2 0.0 6.6 7 0 0 7 7 6 3 HEAT repeat HEAT_EZ PF13513.6 PIK43157.1 - 1.4e-10 41.4 2.2 0.0079 16.7 0.1 7.7 8 1 1 9 9 9 2 HEAT-like repeat UME PF08064.13 PIK43157.1 - 1.5e-08 34.5 1.0 0.16 11.9 0.0 5.4 4 2 1 5 5 5 2 UME (NUC010) domain Cnd1 PF12717.7 PIK43157.1 - 3e-07 30.6 9.6 0.0092 16.0 1.1 4.8 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK43157.1 - 3.7e-07 29.1 7.1 0.044 12.4 0.2 4.4 3 1 0 5 5 5 3 Adaptin N terminal region TAF6_C PF07571.13 PIK43157.1 - 3e-06 27.5 1.8 0.028 14.7 0.3 4.9 3 2 1 4 4 4 1 TAF6 C-terminal HEAT repeat domain Telomere_reg-2 PF10193.9 PIK43157.1 - 4.6e-06 27.0 1.4 0.068 13.6 0.0 4.2 4 0 0 4 4 4 2 Telomere length regulation protein Cnd3 PF12719.7 PIK43157.1 - 1.6e-05 24.3 6.4 0.062 12.5 0.2 4.2 3 1 2 5 5 5 2 Nuclear condensing complex subunits, C-term domain DUF3385 PF11865.8 PIK43157.1 - 9.5e-05 22.4 2.8 0.0006 19.8 0.0 3.5 4 0 0 4 4 3 1 Domain of unknown function (DUF3385) DRIM PF07539.12 PIK43157.1 - 0.00013 20.5 1.8 0.45 8.8 0.2 4.1 1 1 1 3 3 3 2 Down-regulated in metastasis RTP1_C1 PF10363.9 PIK43157.1 - 0.00055 20.1 1.9 2.4 8.4 0.2 4.0 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 PIK43157.1 - 0.0017 17.7 5.3 1.3 8.2 0.2 3.6 3 1 0 4 4 4 1 V-ATPase subunit H MIEAP PF16026.5 PIK43157.1 - 0.025 14.8 0.6 3.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Mitochondria-eating protein B56 PF01603.20 PIK43157.1 - 0.041 12.9 0.2 0.14 11.1 0.1 1.9 1 1 1 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) MOR2-PAG1_N PF14222.6 PIK43157.1 - 0.049 12.6 0.4 0.3 10.0 0.0 2.4 3 0 0 3 3 3 0 Cell morphogenesis N-terminal DUF4787 PF16029.5 PIK43157.1 - 0.061 13.4 1.9 0.24 11.5 1.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) Arm PF00514.23 PIK43157.1 - 0.081 13.0 3.2 25 5.1 0.1 5.5 8 0 0 8 8 5 0 Armadillo/beta-catenin-like repeat VHS PF00790.19 PIK43157.1 - 0.1 12.4 0.5 2.1 8.2 0.1 3.2 3 0 0 3 3 3 0 VHS domain Sec7_N PF12783.7 PIK43157.1 - 0.11 12.4 2.6 2.1 8.3 0.3 3.8 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal GhoS PF11080.8 PIK43157.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Endoribonuclease GhoS API5 PF05918.11 PIK43157.1 - 0.2 10.4 2.2 7.9 5.2 0.6 3.0 3 0 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) V-ATPase_H_C PF11698.8 PIK43157.1 - 0.29 11.3 5.0 13 6.0 0.2 4.2 3 1 1 4 4 4 0 V-ATPase subunit H DUF3361 PF11841.8 PIK43157.1 - 0.29 11.1 6.1 30 4.5 0.1 4.8 6 0 0 6 6 5 0 Domain of unknown function (DUF3361) RIX1 PF08167.12 PIK43157.1 - 0.57 9.9 12.2 0.73 9.5 0.1 5.1 4 3 0 4 4 4 0 rRNA processing/ribosome biogenesis CUB PF00431.20 PIK43158.1 - 1.2e-58 196.1 5.5 6.3e-27 94.1 0.2 3.3 3 0 0 3 3 3 3 CUB domain Ldl_recept_a PF00057.18 PIK43158.1 - 8.1e-08 32.4 9.3 2.1e-07 31.1 9.3 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Shisa PF13908.6 PIK43158.1 - 0.0092 16.2 1.2 0.017 15.4 1.2 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Comm PF15957.5 PIK43158.1 - 0.039 14.3 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 Commissureless Glyco_transf_49 PF13896.6 PIK43159.1 - 5.1e-59 200.3 3.2 4.6e-46 157.7 3.4 2.2 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 PIK43159.1 - 1.7e-17 63.8 0.7 3.6e-17 62.8 0.7 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 PIK43159.1 - 1.9e-05 24.3 2.5 3.3e-05 23.4 2.5 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Nucleotid_trans PF03407.16 PIK43159.1 - 0.016 15.2 0.2 1.9 8.4 0.3 2.5 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase PRAS PF15798.5 PIK43161.1 - 2.1e-27 96.2 5.0 2.1e-27 96.2 5.0 2.3 4 0 0 4 4 4 1 Proline-rich AKT1 substrate 1 TPR_1 PF00515.28 PIK43162.1 - 2.1e-35 119.1 21.1 9e-07 28.5 0.1 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43162.1 - 2.3e-34 114.7 16.2 9.4e-08 31.6 0.0 8.5 8 0 0 8 8 8 5 Tetratricopeptide repeat DnaJ PF00226.31 PIK43162.1 - 4.2e-23 81.3 5.2 4.2e-23 81.3 5.2 2.8 2 0 0 2 2 2 1 DnaJ domain TPR_19 PF14559.6 PIK43162.1 - 6e-21 74.7 6.7 1.4e-06 28.7 0.1 5.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43162.1 - 2.8e-18 64.5 23.5 0.0076 16.4 0.2 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43162.1 - 1.2e-17 63.3 17.1 0.00021 20.9 0.2 7.6 4 2 4 8 8 8 5 TPR repeat TPR_12 PF13424.6 PIK43162.1 - 9.2e-16 57.9 15.0 1.9e-05 24.8 0.2 6.0 4 2 1 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43162.1 - 1.9e-14 54.0 1.3 0.042 14.5 0.0 5.3 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43162.1 - 1e-09 38.5 19.0 0.00076 19.7 0.2 4.9 2 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 PIK43162.1 - 2.6e-09 37.1 4.8 0.31 12.0 0.0 7.2 4 2 4 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43162.1 - 2.3e-08 33.9 7.2 0.009 16.3 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43162.1 - 3.3e-08 33.0 8.2 0.2 11.7 0.0 6.2 5 1 0 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43162.1 - 8.5e-08 32.4 11.9 0.0033 17.9 0.0 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK43162.1 - 2e-05 24.0 0.3 0.49 9.9 0.0 4.5 4 0 0 4 4 4 2 SHNi-TPR TPR_9 PF13371.6 PIK43162.1 - 9.5e-05 22.5 5.3 5.3 7.3 0.0 5.5 5 2 1 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.17 PIK43162.1 - 0.00091 19.7 6.5 1.5 9.2 0.1 4.2 2 2 2 4 4 4 1 Bacterial transcriptional activator domain PknG_TPR PF16918.5 PIK43162.1 - 0.0012 17.7 0.7 0.075 11.7 0.1 2.6 2 1 1 3 3 3 1 Protein kinase G tetratricopeptide repeat TPR_10 PF13374.6 PIK43162.1 - 0.0028 17.5 10.4 1.8 8.6 0.1 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat MIT PF04212.18 PIK43162.1 - 0.01 15.9 16.8 0.26 11.4 0.1 6.0 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain Rapsyn_N PF10579.9 PIK43162.1 - 0.12 12.5 4.0 3 8.0 0.1 4.1 3 2 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region HemY_N PF07219.13 PIK43162.1 - 0.22 11.7 6.3 32 4.8 0.1 4.2 2 2 3 5 5 5 0 HemY protein N-terminus TPR_3 PF07720.12 PIK43162.1 - 0.23 11.5 14.7 0.39 10.8 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF5344 PF17279.2 PIK43162.1 - 0.61 10.7 7.4 0.52 10.9 0.2 3.3 4 0 0 4 4 3 0 Family of unknown function (DUF5344) DUF357 PF04010.13 PIK43162.1 - 3 8.0 11.0 28 4.9 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF357) Ldl_recept_a PF00057.18 PIK43163.1 - 1.5e-17 63.5 46.6 1.5e-10 41.1 8.3 4.4 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK43163.1 - 1.3e-13 51.2 13.3 6e-08 33.0 0.0 7.8 9 0 0 9 9 9 2 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK43163.1 - 1.5e-11 44.4 61.7 1.1e-08 35.2 9.3 4.5 4 1 0 4 4 4 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK43163.1 - 5.9e-06 26.4 11.8 5.9e-06 26.4 11.8 6.4 3 1 1 4 4 4 1 Calcium-binding EGF domain cEGF PF12662.7 PIK43163.1 - 0.00025 20.9 27.3 0.027 14.4 2.2 4.5 4 0 0 4 4 4 3 Complement Clr-like EGF-like SBBP PF06739.11 PIK43163.1 - 0.017 15.1 0.1 0.68 10.0 0.0 2.7 2 0 0 2 2 2 0 Beta-propeller repeat Ldl_recept_b PF00058.17 PIK43164.1 - 9.7e-27 93.2 8.7 5.8e-08 33.1 0.2 6.4 6 0 0 6 6 6 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK43164.1 - 4.6e-15 55.6 21.9 4.1e-11 43.0 7.3 2.4 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 PIK43164.1 - 8.5e-06 25.2 0.0 0.012 14.9 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF5050) cEGF PF12662.7 PIK43164.1 - 0.00011 22.1 0.4 0.00011 22.1 0.4 2.6 2 1 0 2 2 2 1 Complement Clr-like EGF-like SGL PF08450.12 PIK43164.1 - 0.0033 17.1 1.3 1.1 8.8 0.2 3.9 2 2 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 PIK43164.1 - 3.7 7.9 15.7 0.98 9.8 3.2 2.6 2 0 0 2 2 2 0 EGF-like domain Pkinase_Tyr PF07714.17 PIK43166.1 - 9.1e-81 270.9 0.0 1.3e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43166.1 - 3.2e-34 118.5 0.0 4.8e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK43166.1 - 0.024 15.0 0.1 0.055 13.8 0.1 1.6 1 0 0 1 1 1 0 Fibronectin type III domain Kinase-like PF14531.6 PIK43166.1 - 0.047 13.0 0.0 0.12 11.6 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Acetyltransf_2 PF00797.17 PIK43167.1 - 2.3e-05 24.3 0.0 3.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase SGTA_dimer PF16546.5 PIK43168.1 - 0.11 12.3 0.5 0.11 12.3 0.5 1.6 2 0 0 2 2 2 0 Homodimerisation domain of SGTA DUF2012 PF09430.10 PIK43169.1 - 7.3e-13 48.7 0.0 1.4e-12 47.8 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2012) DUF3552 PF12072.8 PIK43169.1 - 0.21 11.0 0.1 0.29 10.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Pex24p PF06398.11 PIK43170.1 - 0.062 12.3 0.1 0.067 12.2 0.1 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2012 PF09430.10 PIK43171.1 - 2.3e-19 69.7 0.0 3.8e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 PIK43171.1 - 0.072 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DUF2436 PF10365.9 PIK43171.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) AAA_23 PF13476.6 PIK43172.1 - 2.6e-30 106.4 9.3 2.6e-30 106.4 9.3 8.3 2 1 4 6 6 6 1 AAA domain Rad50_zn_hook PF04423.14 PIK43172.1 - 4.2e-10 39.3 0.1 4.2e-10 39.3 0.1 5.8 6 0 0 6 6 6 1 Rad50 zinc hook motif AAA_21 PF13304.6 PIK43172.1 - 4.5e-09 36.5 1.3 0.0013 18.7 0.0 3.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 PIK43172.1 - 3.6e-08 33.5 4.6 3.6e-08 33.5 4.6 5.1 1 1 3 4 4 4 2 AAA ATPase domain SbcCD_C PF13558.6 PIK43172.1 - 1.9e-05 24.8 0.0 0.00016 21.8 0.0 2.5 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 PIK43172.1 - 0.0085 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 PIK43172.1 - 0.07 11.8 0.0 0.07 11.8 0.0 7.5 2 1 4 6 6 6 0 AAA domain ABC_tran PF00005.27 PIK43172.1 - 0.08 13.5 0.0 0.08 13.5 0.0 8.4 3 1 1 4 4 4 0 ABC transporter AAA_16 PF13191.6 PIK43172.1 - 0.33 11.3 0.0 0.33 11.3 0.0 3.9 5 1 0 5 5 5 0 AAA ATPase domain RsgA_GTPase PF03193.16 PIK43172.1 - 0.65 9.9 0.0 0.65 9.9 0.0 4.6 5 2 1 6 6 6 0 RsgA GTPase 3HCDH_N PF02737.18 PIK43173.1 - 6.1e-63 212.0 0.0 9.6e-63 211.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 PIK43173.1 - 1.5e-40 139.1 0.2 4.2e-40 137.6 0.2 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 PIK43173.1 - 4.4e-31 107.4 0.0 3.3e-24 85.3 0.0 3.0 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 PIK43173.1 - 2.2e-27 96.5 0.0 4.4e-27 95.5 0.0 1.6 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pyr_redox_2 PF07992.14 PIK43173.1 - 0.0031 16.8 0.0 0.0069 15.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 PIK43173.1 - 0.0075 16.3 0.0 0.041 13.9 0.0 2.1 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 PIK43173.1 - 0.017 14.7 0.1 0.036 13.6 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 PIK43173.1 - 0.038 14.5 0.2 0.16 12.6 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 PIK43173.1 - 0.083 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ldl_recept_a PF00057.18 PIK43174.1 - 1.1e-35 121.5 106.7 1.4e-08 34.8 3.3 7.3 7 0 0 7 7 7 6 Low-density lipoprotein receptor domain class A DUF5023 PF16426.5 PIK43174.1 - 0.086 12.5 0.2 0.14 11.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5023) Vta1 PF04652.16 PIK43174.1 - 0.39 10.7 3.9 0.6 10.1 3.3 1.5 2 0 0 2 2 2 0 Vta1 like Ldl_recept_a PF00057.18 PIK43175.1 - 7.6e-44 147.6 138.1 7.6e-05 22.8 6.4 10.3 10 0 0 10 10 10 10 Low-density lipoprotein receptor domain class A RMI2 PF16100.5 PIK43175.1 - 2.5e-08 33.8 0.0 61 3.4 0.0 7.8 8 0 0 8 8 8 0 RecQ-mediated genome instability protein 2 Glyco_hydro_30C PF17189.4 PIK43175.1 - 0.0023 18.1 3.4 1.6e+02 2.6 0.0 6.8 7 0 0 7 7 7 0 Glycosyl hydrolase family 30 beta sandwich domain Ada_Zn_binding PF02805.16 PIK43175.1 - 0.0041 17.1 60.8 1.6 8.8 0.9 8.3 8 0 0 8 8 8 8 Metal binding domain of Ada ACBP PF00887.19 PIK43176.1 - 1.9e-10 40.8 0.0 3.6e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein ACBP PF00887.19 PIK43177.1 - 1.7e-31 108.3 0.8 2e-31 108.0 0.8 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Xan_ur_permease PF00860.20 PIK43178.1 - 1.4e-71 241.2 25.7 3.6e-52 177.4 9.6 2.1 1 1 1 2 2 2 2 Permease family Xan_ur_permease PF00860.20 PIK43179.1 - 3.3e-48 164.3 10.4 4.4e-48 163.9 10.4 1.2 1 0 0 1 1 1 1 Permease family Integrin_alpha2 PF08441.12 PIK43180.1 - 9.2e-61 206.1 0.7 1.2e-60 205.8 0.7 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK43180.1 - 7.9e-13 48.3 30.1 2.6e-09 37.0 0.8 5.0 5 0 0 5 5 5 2 FG-GAP repeat VCBS PF13517.6 PIK43180.1 - 8.3e-06 26.3 12.7 0.00011 22.8 6.1 4.0 1 1 3 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK43180.1 - 9.1e-05 22.6 15.2 0.031 14.5 0.2 3.7 3 0 0 3 3 3 3 FG-GAP repeat CARDB PF07705.11 PIK43180.1 - 0.052 13.8 1.4 4 7.8 0.1 3.5 3 0 0 3 3 3 0 CARDB HisK_sensor PF18698.1 PIK43180.1 - 0.097 13.0 0.4 27 5.1 0.0 3.2 3 0 0 3 3 3 0 Histidine kinase sensor domain PNK3P PF08645.11 PIK43181.1 - 5.5e-54 182.2 0.0 1.2e-53 181.1 0.0 1.6 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase FHA_2 PF17913.1 PIK43181.1 - 4.1e-15 55.8 0.3 1.4e-14 54.1 0.3 1.9 1 0 0 1 1 1 1 FHA domain AAA_33 PF13671.6 PIK43181.1 - 8e-14 52.0 3.5 3.8e-12 46.6 0.2 2.9 2 1 0 2 2 2 1 AAA domain FHA PF00498.26 PIK43181.1 - 1.1e-05 25.7 1.7 1.8e-05 25.0 0.6 1.9 2 0 0 2 2 2 1 FHA domain Hydrolase_6 PF13344.6 PIK43181.1 - 0.007 16.5 0.0 0.028 14.5 0.0 2.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase GCV_T_C PF08669.11 PIK43181.1 - 0.076 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Macoilin PF09726.9 PIK43181.1 - 1.3 7.5 15.2 1.7 7.1 15.2 1.1 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 PIK43181.1 - 8.5 4.1 8.4 12 3.6 8.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family adh_short PF00106.25 PIK43182.1 - 1.3e-28 99.8 0.0 7.5e-19 67.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK43182.1 - 3.3e-25 89.0 0.0 2.3e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 PIK43182.1 - 5.4e-06 26.0 0.0 7.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 PIK43182.1 - 7.9e-06 25.9 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 PIK43182.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 PIK43182.1 - 0.025 14.8 0.1 0.22 11.8 0.1 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Glycos_transf_3 PF00591.21 PIK43182.1 - 0.11 12.1 0.1 1.9 8.0 0.0 2.0 1 1 1 2 2 2 0 Glycosyl transferase family, a/b domain DUF2783 PF10932.8 PIK43183.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) TRAP_alpha PF03896.16 PIK43183.1 - 0.25 10.5 1.1 0.4 9.8 1.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Ldl_recept_a PF00057.18 PIK43184.1 - 1.7e-09 37.7 9.0 1.7e-09 37.7 9.0 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A RVT_1 PF00078.27 PIK43184.1 - 4e-08 33.0 0.0 6.1e-07 29.2 0.0 2.6 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK43184.1 - 4.2e-05 23.7 0.7 9.6e-05 22.6 0.7 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain 7tm_2 PF00002.24 PIK43185.1 - 1.2e-07 31.3 4.3 1.6e-07 30.9 4.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 PIK43185.1 - 1.5e-06 27.8 6.5 5.4e-06 26.0 6.5 1.8 1 1 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 PIK43185.1 - 5e-05 23.7 0.1 0.00011 22.6 0.1 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Filo_VP35 PF02097.15 PIK43185.1 - 0.038 13.1 0.2 0.057 12.5 0.2 1.2 1 0 0 1 1 1 0 Filoviridae VP35 TraL PF07178.11 PIK43185.1 - 0.069 13.6 0.3 0.16 12.5 0.3 1.5 1 0 0 1 1 1 0 TraL protein GOLGA2L5 PF15070.6 PIK43185.1 - 0.13 10.9 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 7tm_2 PF00002.24 PIK43186.1 - 2.8e-17 62.8 8.9 3.3e-17 62.6 8.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF3687 PF12459.8 PIK43186.1 - 0.044 13.3 0.2 0.044 13.3 0.2 2.6 3 1 0 3 3 3 0 D-Ala-teichoic acid biosynthesis protein Epiglycanin_C PF14654.6 PIK43186.1 - 1.7 8.7 6.8 2.8 8.1 0.3 2.5 2 1 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region UPF0182 PF03699.13 PIK43186.1 - 2.1 6.4 4.5 2.7 6.0 4.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) FA_desaturase PF00487.24 PIK43186.1 - 5.8 6.7 9.0 0.86 9.4 4.8 1.6 1 1 1 2 2 2 0 Fatty acid desaturase Pkinase_Tyr PF07714.17 PIK43187.1 - 6.7e-50 169.8 0.0 7.2e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43187.1 - 1.6e-11 44.1 0.0 1.9e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43188.1 - 6.8e-22 78.0 0.0 1e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43188.1 - 7.2e-08 32.1 0.0 9.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Adeno_E3_CR2 PF02439.15 PIK43188.1 - 0.033 14.0 5.5 0.072 12.9 5.5 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Tweety PF04906.13 PIK43188.1 - 0.065 11.9 0.1 0.09 11.4 0.1 1.1 1 0 0 1 1 1 0 Tweety TMEM52 PF14979.6 PIK43188.1 - 0.081 12.8 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Transmembrane 52 VirB3 PF05101.13 PIK43188.1 - 0.096 12.9 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Baculo_F PF12259.8 PIK43188.1 - 0.32 9.5 2.2 0.41 9.1 2.2 1.1 1 0 0 1 1 1 0 Baculovirus F protein DUF148 PF02520.17 PIK43189.1 - 0.011 15.8 1.6 0.029 14.5 1.0 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF4618 PF15397.6 PIK43189.1 - 0.013 14.9 0.7 0.013 14.9 0.7 1.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) KxDL PF10241.9 PIK43189.1 - 0.018 15.3 1.3 0.057 13.7 0.8 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein SPATA24 PF15175.6 PIK43189.1 - 0.018 14.9 4.2 0.029 14.3 4.2 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 Transposase_22 PF02994.14 PIK43189.1 - 0.082 13.1 0.5 0.62 10.3 0.5 2.3 1 1 0 1 1 1 0 L1 transposable element RBD-like domain HIP1_clath_bdg PF16515.5 PIK43189.1 - 0.1 13.2 1.7 0.27 11.8 1.7 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1664 PF07889.12 PIK43189.1 - 0.13 12.3 0.3 0.3 11.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FAM184 PF15665.5 PIK43189.1 - 0.23 11.2 5.6 0.097 12.4 3.3 1.5 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B BTD PF09270.10 PIK43190.1 - 3e-73 245.1 0.2 7.6e-73 243.8 0.0 1.8 2 0 0 2 2 2 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 PIK43190.1 - 2.1e-46 158.3 1.0 4.1e-46 157.3 1.0 1.5 1 0 0 1 1 1 1 LAG1, DNA binding TIG PF01833.24 PIK43190.1 - 0.067 13.3 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 IPT/TIG domain COMM_domain PF07258.14 PIK43193.1 - 1.3e-16 60.4 0.3 2.9e-16 59.4 0.3 1.6 1 0 0 1 1 1 1 COMM domain AbiGi PF10899.8 PIK43193.1 - 0.0026 17.6 0.0 0.0039 17.0 0.0 1.3 1 1 0 1 1 1 1 Putative abortive phage resistance protein AbiGi, antitoxin SufE PF02657.15 PIK43193.1 - 0.056 13.3 0.1 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Fe-S metabolism associated domain LRR_8 PF13855.6 PIK43194.1 - 6e-41 138.0 39.9 1e-14 54.0 6.3 5.2 2 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 PIK43194.1 - 4.6e-17 61.9 32.5 4.7e-05 23.7 0.6 5.1 4 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK43194.1 - 8.7e-17 61.3 3.0 1.5e-11 44.4 0.1 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK43194.1 - 2.5e-05 24.2 27.4 1.6 9.6 0.1 8.1 7 2 1 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK43194.1 - 0.00026 20.5 9.3 0.033 13.7 0.5 3.1 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 PIK43194.1 - 0.0011 18.8 15.5 0.64 10.2 0.3 5.7 5 0 0 5 5 5 2 Leucine Rich repeat DUF4280 PF14107.6 PIK43194.1 - 0.039 14.8 0.4 0.68 10.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4280) LRR_8 PF13855.6 PIK43195.1 - 4.3e-31 106.5 33.7 4.8e-13 48.7 8.1 5.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK43195.1 - 2.9e-12 46.7 1.0 2.1e-07 30.9 0.0 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK43195.1 - 9.3e-12 45.0 34.1 2e-05 24.8 0.4 5.8 2 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK43195.1 - 8.1e-06 25.4 9.4 0.026 14.0 1.7 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK43195.1 - 6.8e-05 22.9 30.9 1.1 10.1 0.9 8.5 8 1 0 8 8 8 4 Leucine Rich Repeat LRR_8 PF13855.6 PIK43196.1 - 1.6e-31 107.8 44.2 3.6e-12 45.9 10.5 5.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK43196.1 - 3.8e-12 46.3 8.0 1.6e-08 34.6 0.1 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK43196.1 - 3.1e-10 40.1 43.1 2e-05 24.9 0.5 6.0 2 1 6 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK43196.1 - 1.4e-05 24.7 9.8 0.061 12.8 0.2 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK43196.1 - 0.036 14.6 36.1 0.91 10.3 0.9 8.6 9 1 0 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK43196.1 - 2.3 8.5 29.8 2.2 8.6 0.1 6.6 7 0 0 7 7 7 0 Leucine Rich repeat Ras PF00071.22 PIK43197.1 - 3.5e-21 75.5 0.4 7e-21 74.5 0.1 1.6 2 0 0 2 2 2 1 Ras family VWA_2 PF13519.6 PIK43197.1 - 7.7e-07 29.7 0.0 0.00063 20.4 0.0 2.8 2 1 0 2 2 2 1 von Willebrand factor type A domain zf-Sec23_Sec24 PF04810.15 PIK43197.1 - 8.6e-06 25.7 0.9 2.2e-05 24.4 0.9 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.15 PIK43197.1 - 2.3e-05 24.1 0.0 0.011 15.4 0.0 2.5 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain VWA PF00092.28 PIK43197.1 - 0.00012 22.4 0.6 0.0021 18.3 0.2 3.1 2 2 0 2 2 2 1 von Willebrand factor type A domain PHD PF00628.29 PIK43197.1 - 0.076 12.9 1.7 0.23 11.4 1.7 1.8 1 0 0 1 1 1 0 PHD-finger GPP34 PF05719.11 PIK43198.1 - 1.1e-54 185.5 0.3 1.3e-54 185.3 0.3 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) FAST_1 PF06743.15 PIK43200.1 - 9.2e-13 48.0 0.1 1.5e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 PIK43200.1 - 2.7e-11 44.1 0.0 5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 VraX PF17412.2 PIK43200.1 - 0.014 15.1 0.5 0.029 14.0 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function Bac_chlorC PF02043.17 PIK43200.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein p450 PF00067.22 PIK43202.1 - 4.1e-42 144.5 0.0 5.7e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LPD26 PF18842.1 PIK43202.1 - 0.17 11.9 0.1 0.42 10.6 0.1 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 DUF3311 PF11755.8 PIK43202.1 - 5 7.1 5.3 7.9 6.5 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3311) Fibrinogen_C PF00147.18 PIK43203.1 - 1.3e-80 270.4 8.1 1.5e-80 270.2 8.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain AAA_30 PF13604.6 PIK43205.1 - 1.3e-21 77.2 0.0 2.2e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK43205.1 - 9.3e-14 52.0 0.0 1.9e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK43205.1 - 0.0038 17.1 1.5 0.0066 16.3 0.2 2.0 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 PIK43205.1 - 0.0067 16.3 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Helicase RRM_1 PF00076.22 PIK43206.1 - 1.7e-11 43.8 0.0 3.6e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK43206.1 - 0.0062 16.6 0.0 0.015 15.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif DUF3791 PF12668.7 PIK43206.1 - 0.18 11.9 0.2 0.5 10.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) 7tm_1 PF00001.21 PIK43208.1 - 5.6e-13 48.8 0.1 5.9e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK43208.1 - 0.0003 20.2 2.4 0.00034 20.0 2.4 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw HDNR PF15115.6 PIK43209.1 - 4e-31 108.6 4.5 5.3e-31 108.2 4.5 1.2 1 0 0 1 1 1 1 Domain of unknown function with conserved HDNR motif CLTH PF10607.9 PIK43210.1 - 4.6e-28 98.0 0.1 9.6e-28 96.9 0.1 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain ARL2_Bind_BART PF11527.8 PIK43210.1 - 0.12 12.5 0.4 0.64 10.1 0.0 2.3 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART RhoGAP PF00620.27 PIK43211.1 - 3e-31 108.3 0.2 5.8e-31 107.4 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain ER-remodelling PF14755.6 PIK43211.1 - 0.15 12.4 8.3 0.028 14.7 3.7 2.2 2 1 0 2 2 2 0 Intracellular membrane remodeller RNase_HII PF01351.18 PIK43212.1 - 7.9e-30 104.2 0.0 1.2e-29 103.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII Aminotran_1_2 PF00155.21 PIK43213.1 - 5.1e-83 279.2 0.0 6.8e-83 278.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_28 PF17937.1 PIK43213.1 - 0.1 13.1 0.1 4.8 7.7 0.1 2.9 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Daxx PF03344.15 PIK43214.1 - 0.088 12.9 0.0 8.3 6.6 0.0 2.8 2 0 0 2 2 2 0 Daxx N-terminal Rassf1C-interacting domain Cation_ATPase_C PF00689.21 PIK43215.1 - 5.1 6.8 11.9 1 9.1 2.6 2.3 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus Ag332 PF04671.12 PIK43216.1 - 2.2 8.3 4.6 0.88 9.6 1.6 2.0 2 0 0 2 2 2 0 Erythrocyte membrane-associated giant protein antigen 332 Integrase_H2C2 PF17921.1 PIK43218.1 - 2.3e-16 59.6 5.0 4.3e-16 58.8 5.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK43219.1 - 1.2e-09 38.0 0.0 1.4e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Myb_DNA-bind_5 PF13873.6 PIK43220.1 - 3.3e-14 52.7 0.6 1.1e-13 51.1 0.6 1.9 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain RNase_E_G PF10150.9 PIK43220.1 - 0.055 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease E/G family DDE_Tnp_4 PF13359.6 PIK43221.1 - 8.9e-15 54.7 0.1 2.8e-08 33.6 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease UIM PF02809.20 PIK43223.1 - 0.027 14.4 0.8 0.054 13.4 0.8 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif zf-CCHC PF00098.23 PIK43224.1 - 0.00012 21.9 2.9 0.00021 21.2 2.9 1.4 1 0 0 1 1 1 1 Zinc knuckle Activator-TraM PF11657.8 PIK43224.1 - 0.083 12.7 0.1 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 Transcriptional activator TraM RVT_2 PF07727.14 PIK43224.1 - 0.13 11.9 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK43225.1 - 5.5e-11 42.4 0.0 7.7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK43226.1 - 7e-32 110.7 0.0 1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK43226.1 - 6.5e-10 38.9 0.1 1.1e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MULE PF10551.9 PIK43227.1 - 0.097 13.1 0.0 0.41 11.1 0.0 1.9 2 0 0 2 2 2 0 MULE transposase domain DUF1759 PF03564.15 PIK43228.1 - 1.4e-08 34.8 0.0 1.5e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) zf-CCHC PF00098.23 PIK43229.1 - 0.00022 21.1 0.2 0.00046 20.1 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43229.1 - 0.0074 16.1 0.2 0.016 15.1 0.2 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF4198 PF10670.9 PIK43229.1 - 0.13 12.6 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) zf-CCHC_3 PF13917.6 PIK43229.1 - 0.18 11.8 0.3 0.32 11.0 0.3 1.4 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 PIK43231.1 - 9.5e-17 61.2 0.0 1.3e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) THAP PF05485.12 PIK43232.1 - 5e-16 59.4 0.0 8.4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 THAP domain Corona_NSP4_C PF16348.5 PIK43233.1 - 0.038 14.8 0.0 0.055 14.3 0.0 1.2 1 0 0 1 1 1 0 Coronavirus nonstructural protein 4 C-terminus THAP PF05485.12 PIK43235.1 - 5.2e-13 49.7 0.4 8.4e-13 49.1 0.4 1.3 1 0 0 1 1 1 1 THAP domain SAM_2 PF07647.17 PIK43235.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HECT PF00632.25 PIK43236.1 - 1.1e-08 35.0 0.1 0.00064 19.3 0.1 2.3 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Peptidase_C3G PF12381.8 PIK43236.1 - 0.038 13.5 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase ToxS PF17323.2 PIK43236.1 - 0.048 13.3 1.0 0.54 9.9 0.6 2.1 2 0 0 2 2 2 0 Trans-membrane regulatory protein ToxS Mannitol_dh_C PF08125.13 PIK43236.1 - 0.073 12.5 0.3 0.12 11.8 0.3 1.3 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain rve PF00665.26 PIK43237.1 - 1.5e-05 25.2 0.1 3.5e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain TPR_1 PF00515.28 PIK43239.1 - 4.2e-20 70.6 18.8 0.0034 17.1 0.1 8.4 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43239.1 - 6.8e-20 70.5 3.0 3.2e-07 29.9 0.1 5.6 4 1 1 5 5 5 3 TPR repeat TPR_2 PF07719.17 PIK43239.1 - 3e-18 64.4 14.3 0.047 13.8 0.0 8.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43239.1 - 7.8e-18 63.1 16.0 0.0053 16.9 0.0 8.2 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43239.1 - 5.7e-14 51.6 8.4 0.0021 18.7 0.0 7.4 2 1 6 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43239.1 - 2.8e-12 46.8 13.5 0.0017 18.6 0.1 5.1 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43239.1 - 1.4e-11 44.8 5.4 0.00013 22.5 0.4 4.7 5 1 0 6 6 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43239.1 - 1.5e-11 43.8 7.2 0.054 13.9 0.0 6.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43239.1 - 3e-08 33.7 5.9 0.0039 17.3 0.1 4.4 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43239.1 - 3.5e-07 30.6 15.8 0.058 13.9 0.2 6.1 3 1 4 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43239.1 - 4.1e-07 30.2 10.6 0.99 10.2 0.2 8.1 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43239.1 - 0.00028 21.0 2.7 4.5 7.6 0.0 5.3 2 2 3 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK43239.1 - 0.00079 19.3 0.2 40 4.5 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 PIK43239.1 - 0.00087 18.6 1.8 0.46 9.6 0.1 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF5569 PF17729.1 PIK43239.1 - 0.0025 17.7 0.1 0.041 13.8 0.0 2.6 2 1 0 3 3 3 1 Family of unknown function (DUF5569) TPR_21 PF09976.9 PIK43239.1 - 0.0097 15.6 8.0 0.1 12.3 0.5 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat-like domain ST7 PF04184.12 PIK43239.1 - 0.016 13.7 1.0 0.022 13.3 0.2 1.6 2 0 0 2 2 2 0 ST7 protein TPR_MalT PF17874.1 PIK43239.1 - 0.095 12.0 4.7 0.37 10.1 2.5 2.8 2 1 2 4 4 4 0 MalT-like TPR region TPR_10 PF13374.6 PIK43239.1 - 0.17 11.8 10.5 5 7.1 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat COG2 PF06148.11 PIK43239.1 - 0.7 10.0 3.3 0.38 10.9 0.4 2.1 2 0 0 2 2 1 0 COG (conserved oligomeric Golgi) complex component, COG2 ANAPC5 PF12862.7 PIK43239.1 - 0.72 10.0 4.8 3.2 7.9 0.6 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 SHNi-TPR PF10516.9 PIK43239.1 - 0.96 9.0 3.0 11 5.5 0.0 3.5 4 0 0 4 4 4 0 SHNi-TPR Y_phosphatase PF00102.27 PIK43241.1 - 8.2e-74 248.1 2.3 1.1e-43 149.5 0.2 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK43241.1 - 0.0006 19.6 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK43241.1 - 0.00073 19.7 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Stevor PF17410.2 PIK43242.1 - 0.0068 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Herpes_gE PF02480.16 PIK43242.1 - 0.016 13.9 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Vpu PF00558.19 PIK43242.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Vpu protein DUF5385 PF17359.2 PIK43242.1 - 0.2 11.2 0.0 0.41 10.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) RVT_1 PF00078.27 PIK43243.1 - 8.2e-17 61.5 0.0 1.1e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK43243.1 - 0.00019 21.4 0.1 0.00057 19.9 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF2789 PF10982.8 PIK43243.1 - 0.051 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) Ldl_recept_a PF00057.18 PIK43244.1 - 1.1e-68 227.2 153.0 1.7e-11 44.1 11.4 9.3 9 1 1 10 10 10 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK43244.1 - 2.4e-27 95.1 10.6 1.5e-10 41.4 0.2 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.15 PIK43244.1 - 1.3e-06 28.5 10.3 1.3e-06 28.5 10.3 9.0 5 3 5 10 10 10 1 Calcium-binding EGF domain SL4P PF17618.2 PIK43244.1 - 0.00063 19.7 0.0 0.52 10.4 0.0 3.6 4 0 0 4 4 4 1 Uncharacterized Strongylid L4 protein SGL PF08450.12 PIK43244.1 - 0.0031 17.2 2.8 0.17 11.4 0.3 3.3 1 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 PIK43244.1 - 0.0035 17.6 7.7 0.0035 17.6 7.7 6.6 7 1 0 7 7 7 2 Coagulation Factor Xa inhibitory site Orf78 PF06024.12 PIK43244.1 - 0.045 14.1 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) MFS_Mycoplasma PF07672.13 PIK43244.1 - 0.062 12.6 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter LMBR1 PF04791.16 PIK43245.1 - 1.3e-94 318.0 20.9 4.2e-82 276.7 6.6 2.4 2 1 1 3 3 3 2 LMBR1-like membrane protein DUF3119 PF11317.8 PIK43245.1 - 0.36 11.1 1.9 0.43 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3119) DUF872 PF05915.12 PIK43245.1 - 1.1 9.5 6.2 0.84 9.8 2.4 2.6 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) RNase_T PF00929.24 PIK43246.1 - 4.6e-32 111.8 0.1 5.3e-32 111.6 0.1 1.0 1 0 0 1 1 1 1 Exonuclease Tim17 PF02466.19 PIK43247.1 - 5.3e-20 71.9 5.0 7.3e-20 71.4 5.0 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Calici_PP_N PF08405.11 PIK43247.1 - 0.034 13.0 0.0 0.036 12.9 0.0 1.1 1 0 0 1 1 1 0 Viral polyprotein N-terminal GHMP_kinases_N PF00288.26 PIK43247.1 - 0.091 13.0 2.6 0.29 11.4 0.3 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain Gar1 PF04410.14 PIK43248.1 - 1.5e-42 145.0 0.0 4.7e-42 143.4 0.0 1.9 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region RR_TM4-6 PF06459.12 PIK43249.1 - 1.9 8.2 5.6 3 7.6 5.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cohesin_HEAT PF12765.7 PIK43250.1 - 9.6e-13 48.2 0.5 7.5e-11 42.1 0.1 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion SDA1 PF05285.12 PIK43250.1 - 0.00045 19.7 35.3 0.0024 17.4 13.2 2.3 2 0 0 2 2 2 2 SDA1 HEAT PF02985.22 PIK43250.1 - 0.0016 18.5 6.1 2.6 8.5 0.0 6.7 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.7 PIK43250.1 - 0.0072 16.4 5.2 0.26 11.3 0.5 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RNase_H2_suC PF08615.11 PIK43250.1 - 0.077 13.2 2.1 4.6 7.4 0.1 2.6 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) GAGA_bind PF06217.12 PIK43250.1 - 0.23 11.7 5.7 0.85 9.8 5.7 1.9 1 0 0 1 1 1 0 GAGA binding protein-like family CNOT11 PF10155.9 PIK43250.1 - 0.26 11.4 3.9 32 4.7 0.0 5.0 4 2 1 5 5 5 0 CCR4-NOT transcription complex subunit 11 BUD22 PF09073.10 PIK43250.1 - 1.2 8.4 38.4 0.51 9.6 18.2 2.6 2 1 0 2 2 2 0 BUD22 DUF913 PF06025.12 PIK43250.1 - 1.8 7.4 11.1 0.12 11.3 1.8 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF2052 PF09747.9 PIK43250.1 - 4.9 7.2 37.1 0.15 12.2 11.9 3.3 2 1 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF866 PF05907.13 PIK43251.1 - 6.1e-53 178.9 1.5 6.7e-53 178.8 1.5 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) RT_RNaseH_2 PF17919.1 PIK43252.1 - 1.2e-37 127.9 0.0 2.1e-37 127.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK43252.1 - 8.8e-36 122.4 0.0 1.8e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK43253.1 - 8.1e-19 67.5 0.1 2.3e-18 66.0 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK43253.1 - 1.1e-16 61.1 0.0 3e-16 59.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK43253.1 - 4.2e-13 48.9 0.0 1.3e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK43253.1 - 2.8e-06 27.1 2.0 6.8e-06 25.9 2.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 PIK43253.1 - 0.0012 19.0 2.9 0.0012 19.0 0.0 2.5 3 0 0 3 3 3 1 H2C2 zinc finger zf-CCHC_2 PF13696.6 PIK43253.1 - 0.0064 16.3 1.4 0.013 15.3 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK43253.1 - 0.0087 15.8 0.2 0.055 13.3 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain YqaJ PF09588.10 PIK43254.1 - 1.9e-12 47.6 0.0 5.1e-12 46.2 0.0 1.7 1 1 0 1 1 1 1 YqaJ-like viral recombinase domain Viral_alk_exo PF01771.17 PIK43254.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Viral alkaline exonuclease EamA PF00892.20 PIK43255.1 - 5.3e-17 62.3 40.5 2e-09 37.8 14.0 2.0 2 0 0 2 2 2 2 EamA-like transporter family Acetyltransf_2 PF00797.17 PIK43256.1 - 2.7e-08 33.9 0.8 7.6e-08 32.4 0.8 1.7 1 1 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 PIK43257.1 - 7e-05 22.7 0.1 0.00013 21.8 0.1 1.5 1 1 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 PIK43258.1 - 7.4e-08 32.5 0.3 1.6e-07 31.4 0.1 1.7 2 0 0 2 2 2 1 N-acetyltransferase CUE PF02845.16 PIK43258.1 - 0.11 12.2 0.1 0.72 9.6 0.0 2.2 2 0 0 2 2 2 0 CUE domain EamA PF00892.20 PIK43259.1 - 1.8e-14 54.1 39.4 3.4e-09 37.0 13.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family Arrestin_C PF02752.22 PIK43261.1 - 2.6e-16 60.3 0.3 2e-15 57.4 0.1 2.4 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 PIK43261.1 - 3.7e-16 59.5 0.0 2e-14 53.9 0.0 2.8 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Acetyltransf_2 PF00797.17 PIK43262.1 - 1.8e-10 41.0 0.0 2.5e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase PC-Esterase PF13839.6 PIK43263.1 - 0.014 15.2 0.0 0.95 9.1 0.1 2.3 2 0 0 2 2 2 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Lipase_GDSL_2 PF13472.6 PIK43263.1 - 0.066 13.6 0.0 0.1 13.0 0.0 1.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Neurexophilin PF06312.12 PIK43263.1 - 0.074 12.5 0.0 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 Neurexophilin DUF1280 PF06918.14 PIK43264.1 - 9.4e-05 22.1 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1280) Neur_chan_LBD PF02931.23 PIK43265.1 - 7.8e-18 64.7 0.0 8.7e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK43266.1 - 8.6e-47 160.2 0.1 1e-46 159.9 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SE PF08491.10 PIK43266.1 - 0.09 11.8 0.2 0.16 10.9 0.2 1.3 1 0 0 1 1 1 0 Squalene epoxidase STN1_2 PF09170.10 PIK43267.1 - 1.2e-24 87.5 0.9 2.5e-24 86.4 0.6 1.6 2 0 0 2 2 2 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 tRNA_anti-codon PF01336.25 PIK43267.1 - 6.6e-07 29.2 0.0 2.4e-06 27.4 0.0 2.0 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain Cdc6_C PF09079.11 PIK43267.1 - 0.031 14.3 0.2 0.095 12.7 0.2 1.9 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Ank_4 PF13637.6 PIK43268.1 - 4.5e-08 33.5 0.3 9.4e-07 29.3 0.2 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK43268.1 - 6.4e-08 32.7 0.0 5.1e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK43268.1 - 8.9e-08 32.6 0.1 0.00025 21.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK43268.1 - 3e-05 24.3 0.1 0.012 16.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 PIK43268.1 - 0.0044 17.4 0.2 0.29 11.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat SAND PF01342.21 PIK43269.1 - 5.4e-24 83.7 0.0 1.2e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 SAND domain zf-MYND PF01753.18 PIK43269.1 - 1.9e-08 34.2 15.8 1.9e-08 34.2 15.8 2.2 2 0 0 2 2 2 1 MYND finger SBDS_C PF09377.10 PIK43269.1 - 0.029 14.4 0.6 0.061 13.3 0.6 1.5 1 0 0 1 1 1 0 SBDS protein C-terminal domain Metal_resist PF13801.6 PIK43269.1 - 0.039 14.1 5.8 0.065 13.4 5.8 1.3 1 0 0 1 1 1 0 Heavy-metal resistance vATP-synt_E PF01991.18 PIK43269.1 - 0.13 11.7 6.3 0.2 11.1 6.3 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF1839 PF08893.10 PIK43269.1 - 2.6 7.2 5.3 3.5 6.7 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) NPL PF17800.1 PIK43270.1 - 1.4e-18 67.3 0.3 3.2e-18 66.2 0.1 1.6 2 0 0 2 2 2 1 Nucleoplasmin-like domain Sulfotransfer_1 PF00685.27 PIK43271.1 - 1.8e-11 44.0 0.1 2.7e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain DUF1676 PF07898.13 PIK43271.1 - 0.018 15.1 0.0 0.018 15.1 0.0 3.6 5 2 0 5 5 5 0 Protein of unknown function (DUF1676) Orf78 PF06024.12 PIK43271.1 - 0.019 15.3 4.3 0.019 15.3 4.3 7.9 4 2 1 5 5 5 0 Orf78 (ac78) SARAF PF06682.12 PIK43271.1 - 0.14 11.8 0.0 0.14 11.8 0.0 2.1 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis ABC2_membrane_3 PF12698.7 PIK43271.1 - 0.15 11.1 0.4 0.25 10.4 0.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Sugar_tr PF00083.24 PIK43272.1 - 1.3e-24 86.9 8.0 2e-24 86.3 8.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK43272.1 - 6.1e-20 71.4 48.6 4.8e-17 61.9 25.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CLCA PF08434.11 PIK43273.1 - 5.3e-17 62.0 0.0 9.2e-16 58.0 0.0 2.0 1 1 0 1 1 1 1 Calcium-activated chloride channel N terminal YtkA PF13115.6 PIK43274.1 - 0.0013 19.3 2.1 0.0028 18.2 0.1 2.6 2 1 0 2 2 2 1 YtkA-like ChapFlgA_N PF17656.1 PIK43274.1 - 0.043 14.0 0.1 0.71 10.1 0.1 2.8 3 0 0 3 3 3 0 FlgA N-terminal domain TMEM154 PF15102.6 PIK43274.1 - 0.074 13.0 0.2 0.22 11.4 0.0 1.9 1 1 1 2 2 2 0 TMEM154 protein family SIT PF15330.6 PIK43275.1 - 0.013 15.9 0.1 0.04 14.4 0.1 1.8 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.6 PIK43275.1 - 0.027 14.4 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Tmemb_9 PF05434.11 PIK43275.1 - 0.047 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 TMEM9 EphA2_TM PF14575.6 PIK43275.1 - 0.051 14.5 0.1 0.088 13.7 0.1 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4577 PF15145.6 PIK43275.1 - 0.13 12.3 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) NACHT PF05729.12 PIK43276.1 - 6.3e-08 32.7 0.0 1.3e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain GPI2 PF06432.11 PIK43276.1 - 0.0013 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_25 PF13481.6 PIK43276.1 - 0.016 14.8 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain fn3 PF00041.21 PIK43277.1 - 3.1e-90 296.6 39.3 1.5e-09 38.1 0.3 14.2 14 0 0 14 14 14 14 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK43277.1 - 5.9e-11 42.8 23.6 0.66 10.6 0.0 10.7 9 3 1 10 10 10 5 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK43277.1 - 1.2e-08 35.1 3.5 0.054 13.8 0.0 6.3 6 1 1 7 7 7 3 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 PIK43277.1 - 1.4 9.4 7.2 53 4.3 0.0 5.5 7 0 0 7 7 7 0 Uncharacterised conserved protein (DUF2369) rve PF00665.26 PIK43278.1 - 4.4e-15 55.9 0.0 7.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DNA_pol_B_2 PF03175.13 PIK43279.1 - 2.4e-26 92.6 1.5 4.6e-19 68.6 0.1 2.1 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral Plus-3 PF03126.18 PIK43279.1 - 0.25 11.9 1.8 0.34 11.4 0.0 2.1 3 0 0 3 3 3 0 Plus-3 domain DNA_pol_B_2 PF03175.13 PIK43280.1 - 1.6e-21 76.7 0.9 2.8e-21 76.0 0.9 1.3 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DUF4082 PF13313.6 PIK43280.1 - 0.033 14.2 0.2 0.081 13.0 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) WW PF00397.26 PIK43280.1 - 0.071 13.2 1.4 0.29 11.2 1.4 2.1 1 0 0 1 1 1 0 WW domain PC4 PF02229.16 PIK43281.1 - 1.6e-16 59.6 0.0 2.8e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) WW PF00397.26 PIK43281.1 - 0.026 14.6 1.5 0.05 13.7 0.3 2.1 2 0 0 2 2 2 0 WW domain zf-CCHC PF00098.23 PIK43283.1 - 7.3e-10 38.5 16.6 0.0018 18.3 2.2 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43283.1 - 0.00057 19.7 13.2 0.00097 18.9 1.2 3.2 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43283.1 - 0.0035 17.1 10.7 0.056 13.3 0.2 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43283.1 - 0.033 13.9 0.4 0.033 13.9 0.4 3.2 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK43283.1 - 0.25 11.3 12.1 0.057 13.4 3.5 2.9 1 1 1 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK43283.1 - 2.2 8.1 11.5 0.51 10.1 1.5 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger MGC-24 PF05283.11 PIK43283.1 - 9 6.7 16.0 22 5.5 16.0 1.7 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin fn3 PF00041.21 PIK43284.1 - 2.7e-23 82.1 1.0 2e-10 40.9 0.0 3.2 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK43284.1 - 0.0098 16.4 1.3 3.1 8.4 0.0 3.3 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Glyco_hydro_36C PF16874.5 PIK43284.1 - 0.07 13.6 0.0 3.2 8.3 0.0 2.7 3 0 0 3 3 3 0 Glycosyl hydrolase family 36 C-terminal domain DUF3261 PF11659.8 PIK43284.1 - 0.096 12.5 0.0 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3261) DUF4945 PF16303.5 PIK43284.1 - 0.14 12.0 0.0 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4945) fn3 PF00041.21 PIK43285.1 - 1.2e-19 70.4 0.3 1.3e-08 35.1 0.0 3.1 3 0 0 3 3 3 3 Fibronectin type III domain fn3 PF00041.21 PIK43286.1 - 1e-52 176.4 25.5 4.1e-07 30.3 0.0 9.2 8 1 1 9 9 9 9 Fibronectin type III domain Interfer-bind PF09294.10 PIK43286.1 - 1.9e-07 31.3 0.3 0.03 14.6 0.0 4.9 7 0 0 7 7 7 2 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 PIK43286.1 - 7.6e-05 23.2 16.2 3.1 8.4 0.0 7.5 6 4 0 6 6 6 3 Purple acid Phosphatase, N-terminal domain Arylsulfotran_N PF17425.2 PIK43286.1 - 0.016 15.2 0.3 0.18 11.8 0.0 3.0 4 0 0 4 4 4 0 Arylsulfotransferase Ig-like domain DUF4959 PF16323.5 PIK43286.1 - 0.021 15.2 0.0 0.23 11.8 0.0 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4959) PTP_tm PF18861.1 PIK43286.1 - 0.025 14.6 0.2 0.074 13.0 0.1 1.9 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Y_phosphatase PF00102.27 PIK43287.1 - 3e-53 180.8 0.0 4.1e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF1870 PF08965.10 PIK43287.1 - 0.035 14.1 0.5 0.11 12.5 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1870) FAD_binding_7 PF03441.14 PIK43288.1 - 1.1e-60 204.6 0.1 2e-60 203.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 PIK43288.1 - 4.1e-36 124.5 0.0 6.4e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Pkinase PF00069.25 PIK43289.1 - 2.8e-51 174.4 0.0 3.2e-51 174.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43289.1 - 1.4e-34 119.6 0.0 1.7e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK43289.1 - 7.8e-05 22.1 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK43289.1 - 0.0011 18.0 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK43289.1 - 0.048 12.7 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.32 PIK43290.1 - 4.9e-56 185.4 27.0 2e-08 34.7 0.1 11.4 11 0 0 11 11 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43290.1 - 6.1e-21 74.5 7.6 0.00025 21.3 0.0 8.1 3 2 6 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain Utp13 PF08625.11 PIK43290.1 - 1.8e-18 66.8 0.0 3.6e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nucleoporin_N PF08801.11 PIK43290.1 - 9.5e-09 34.5 10.0 0.026 13.3 0.1 5.3 2 2 3 5 5 5 4 Nup133 N terminal like Ge1_WD40 PF16529.5 PIK43290.1 - 1.5e-06 27.4 9.1 0.38 9.7 0.0 6.5 2 2 5 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK43290.1 - 3e-06 26.2 16.4 0.071 11.8 0.0 5.9 3 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK43290.1 - 6.1e-05 22.5 1.3 0.053 12.8 0.0 4.4 3 2 2 5 5 5 2 WD40-like domain ELYS-bb PF16687.5 PIK43290.1 - 0.018 13.7 0.2 11 4.5 0.0 4.0 3 1 2 5 5 5 0 beta-propeller of ELYS nucleoporin DUF839 PF05787.13 PIK43290.1 - 0.019 14.1 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) Pox_TAP PF03355.14 PIK43290.1 - 0.074 12.6 0.4 0.8 9.2 0.0 2.4 2 0 0 2 2 2 0 Viral Trans-Activator Protein Mcl1_mid PF12341.8 PIK43290.1 - 0.12 11.7 2.6 0.39 10.0 0.1 2.9 1 1 1 2 2 2 0 Minichromosome loss protein, Mcl1, middle region MraZ PF02381.18 PIK43290.1 - 0.15 12.0 0.3 1.8 8.6 0.2 2.7 3 0 0 3 3 3 0 MraZ protein, putative antitoxin-like Mito_carr PF00153.27 PIK43291.1 - 2e-63 210.3 0.9 2.8e-20 72.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK43291.1 - 0.1 11.7 0.4 2 7.5 0.0 2.9 3 1 0 3 3 3 0 Gammaproteobacterial serine protease FPP PF05911.11 PIK43292.1 - 0.0016 16.7 0.2 0.0028 15.9 0.2 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Syntaxin-6_N PF09177.11 PIK43292.1 - 0.0034 17.9 1.3 0.011 16.3 0.2 2.1 2 0 0 2 2 2 1 Syntaxin 6, N-terminal BST2 PF16716.5 PIK43292.1 - 0.023 15.3 1.6 0.023 15.3 1.6 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF4559 PF15112.6 PIK43292.1 - 0.054 13.2 0.3 1.7 8.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) VBS PF08913.10 PIK43292.1 - 0.14 12.6 0.4 0.27 11.7 0.1 1.6 2 0 0 2 2 2 0 Vinculin Binding Site HIP1_clath_bdg PF16515.5 PIK43292.1 - 0.27 11.9 7.5 3.5 8.3 2.8 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMPIT PF07851.13 PIK43292.1 - 5.2 6.2 6.8 3.9 6.6 1.7 2.0 1 1 1 2 2 2 0 TMPIT-like protein Laminin_N PF00055.17 PIK43293.1 - 5.2e-72 242.2 0.6 5.2e-72 242.2 0.6 1.7 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 PIK43293.1 - 2.5e-08 33.9 14.0 2.5e-08 33.9 14.0 2.1 2 0 0 2 2 2 1 Laminin EGF domain BNR_2 PF13088.6 PIK43293.1 - 0.051 12.9 0.0 0.074 12.3 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-like domain BNR PF02012.20 PIK43293.1 - 0.88 9.8 2.8 0.79 10.0 0.1 2.5 2 0 0 2 2 2 0 BNR/Asp-box repeat SPG48 PF14764.6 PIK43296.1 - 4.1e-34 117.6 7.4 2.1e-33 115.3 1.5 2.9 3 0 0 3 3 3 2 AP-5 complex subunit, vesicle trafficking Adaptin_N PF01602.20 PIK43296.1 - 0.014 14.0 1.0 0.03 12.9 0.6 1.7 2 1 0 2 2 2 0 Adaptin N terminal region cNMP_binding PF00027.29 PIK43297.1 - 4.8e-39 132.3 0.3 3e-19 68.9 0.1 2.1 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase PF00069.25 PIK43298.1 - 3.3e-18 66.0 0.0 6.9e-18 65.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43298.1 - 9.5e-09 34.9 0.0 3.7e-08 33.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK43298.1 - 0.0017 17.7 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MoCF_biosynth PF00994.24 PIK43299.1 - 2.8e-27 95.2 0.0 4.7e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain PAPS_reduct PF01507.19 PIK43299.1 - 9.2e-26 90.9 0.0 3e-24 86.0 0.0 2.3 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family GTF2I PF02946.14 PIK43300.1 - 3.9e-12 46.1 0.0 7.4e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 GTF2I-like repeat HMG_box_2 PF09011.10 PIK43300.1 - 0.097 13.3 0.4 0.18 12.4 0.4 1.4 1 0 0 1 1 1 0 HMG-box domain Syntaxin-18_N PF10496.9 PIK43300.1 - 0.13 12.5 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus KDZ PF18758.1 PIK43301.1 - 3.7e-36 124.8 0.0 8.8e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase DUF5132 PF17195.4 PIK43302.1 - 0.059 13.5 0.6 0.098 12.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF5132) SAM_1 PF00536.30 PIK43303.1 - 5.4e-31 106.8 4.1 7.9e-17 61.5 0.1 3.3 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK43303.1 - 1.1e-17 63.9 3.8 6e-13 48.7 0.0 4.2 4 0 0 4 4 4 2 SAM domain (Sterile alpha motif) ADIP PF11559.8 PIK43303.1 - 0.016 15.3 30.7 0.87 9.7 5.9 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding SAP PF02037.27 PIK43303.1 - 0.074 12.8 0.1 0.17 11.7 0.1 1.7 1 0 0 1 1 1 0 SAP domain Dna2 PF08696.11 PIK43303.1 - 1.7 8.4 8.3 0.66 9.8 1.9 2.3 1 1 1 2 2 2 0 DNA replication factor Dna2 Spc7 PF08317.11 PIK43303.1 - 7.9 5.3 30.7 0.25 10.2 20.3 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein STN1_2 PF09170.10 PIK43305.1 - 0.00066 19.9 0.1 0.0015 18.8 0.0 1.6 2 0 0 2 2 2 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF1647 PF07801.11 PIK43306.1 - 5.9e-20 71.5 0.4 1.3e-19 70.3 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) Pkinase_Tyr PF07714.17 PIK43307.1 - 3.7e-05 23.1 0.0 5.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43307.1 - 0.005 16.2 0.0 0.0084 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Comm PF15957.5 PIK43307.1 - 0.0056 17.0 0.0 0.022 15.1 0.0 2.0 2 0 0 2 2 2 1 Commissureless GPR15L PF15854.5 PIK43308.1 - 0.71 10.2 17.6 34 4.8 0.4 5.9 5 1 1 6 6 6 0 G-protein coupled receptor ligand 15 GETHR PF05671.11 PIK43309.1 - 0.16 11.3 0.0 62 3.1 0.0 4.4 5 0 0 5 5 5 0 GETHR pentapeptide repeat (5 copies) DUF1647 PF07801.11 PIK43310.1 - 1.4e-18 67.0 0.1 3e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) Shisa PF13908.6 PIK43312.1 - 0.013 15.8 1.4 0.013 15.8 1.4 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF3357 PF11837.8 PIK43312.1 - 0.039 14.4 0.3 0.082 13.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) Ig_3 PF13927.6 PIK43313.1 - 0.00068 20.2 3.9 0.0086 16.7 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain DUF3827 PF12877.7 PIK43313.1 - 0.0014 17.1 0.6 0.002 16.6 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) I-set PF07679.16 PIK43313.1 - 0.018 15.1 0.2 0.059 13.4 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.17 PIK43313.1 - 0.019 15.1 0.4 0.019 15.1 0.4 2.3 2 1 0 2 2 2 0 Immunoglobulin V-set domain NB PF04159.13 PIK43313.1 - 0.15 12.1 6.6 0.12 12.5 1.6 2.6 2 0 0 2 2 2 0 NB glycoprotein Syndecan PF01034.20 PIK43313.1 - 0.23 11.4 3.9 0.59 10.1 3.9 1.7 1 0 0 1 1 1 0 Syndecan domain Retrotrans_gag PF03732.17 PIK43314.1 - 7.5e-05 22.9 0.0 0.00018 21.7 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon gag protein pEK499_p136 PF18736.1 PIK43314.1 - 0.035 13.7 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 HEPN pEK499 p136 Urocanase_N PF17391.2 PIK43314.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Urocanase N-terminal domain RVT_1 PF00078.27 PIK43315.1 - 7.1e-24 84.6 0.1 1.1e-23 83.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK43315.1 - 0.045 14.1 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease TMEM51 PF15345.6 PIK43317.1 - 0.00066 19.6 0.3 0.00066 19.6 0.3 2.0 1 1 1 2 2 2 1 Transmembrane protein 51 KH_9 PF17904.1 PIK43317.1 - 0.084 13.3 1.5 15 6.0 0.1 3.2 1 1 2 3 3 3 0 FMRP KH0 domain PRKCSH PF07915.13 PIK43317.1 - 0.2 12.7 2.9 0.2 12.7 0.2 2.3 2 1 0 2 2 2 0 Glucosidase II beta subunit-like protein DUF4949 PF16307.5 PIK43318.1 - 0.13 12.4 0.1 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4949) DKCLD PF08068.12 PIK43319.1 - 1.7e-32 111.2 0.4 4.2e-32 110.0 0.4 1.7 1 0 0 1 1 1 1 DKCLD (NUC011) domain TruB_N PF01509.18 PIK43319.1 - 3.7e-23 82.5 0.4 2.7e-20 73.3 0.4 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 PIK43319.1 - 4.2e-21 74.9 0.6 9.5e-21 73.7 0.3 1.8 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 PIK43319.1 - 6.4e-19 67.7 0.6 1.2e-18 66.8 0.6 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 PIK43319.1 - 0.0018 18.5 0.0 0.0046 17.2 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain CLZ PF16526.5 PIK43319.1 - 1.9 8.9 4.3 35 4.9 0.0 3.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PIP49_C PF12260.8 PIK43320.1 - 4.1e-40 137.4 0.0 7.1e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 DUF4135 PF13575.6 PIK43320.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) FAM124 PF15067.6 PIK43321.1 - 3.8e-46 157.6 0.0 5.4e-25 88.4 0.0 2.1 1 1 1 2 2 2 2 FAM124 family Abhydrolase_3 PF07859.13 PIK43322.1 - 4.3e-58 196.6 0.0 1e-40 139.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK43322.1 - 2.1e-09 36.8 0.1 7.4e-09 35.0 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK43322.1 - 0.0013 18.3 0.0 0.021 14.3 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK43322.1 - 0.03 13.2 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase Ank_2 PF12796.7 PIK43323.1 - 3e-39 133.5 0.2 3.3e-13 50.0 0.0 5.2 5 1 1 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK43323.1 - 1.3e-29 98.9 4.4 0.00074 19.8 0.0 9.4 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 PIK43323.1 - 8.4e-25 86.5 2.9 0.001 19.4 0.0 8.2 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK43323.1 - 2.4e-23 82.2 4.3 3.7e-05 24.2 0.0 8.2 3 3 5 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 PIK43323.1 - 4.4e-19 68.0 4.5 0.0062 16.9 0.0 8.7 9 0 0 9 9 9 4 Ankyrin repeat SOCS_box PF07525.16 PIK43323.1 - 2.8e-10 40.4 0.5 8.4e-10 38.8 0.5 1.9 1 0 0 1 1 1 1 SOCS box Death PF00531.22 PIK43324.1 - 1.2e-07 31.8 0.0 3.6e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Death domain APP_E2 PF12925.7 PIK43324.1 - 0.021 14.5 0.6 3 7.5 0.2 2.2 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Cep57_CLD_2 PF14197.6 PIK43324.1 - 0.035 14.2 0.3 0.25 11.5 0.3 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Helo_like_N PF17111.5 PIK43324.1 - 0.038 13.3 0.0 0.097 12.0 0.0 1.6 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins APC_N_CC PF16689.5 PIK43324.1 - 0.04 14.0 0.7 0.12 12.5 0.7 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain PRKG1_interact PF15898.5 PIK43324.1 - 0.11 13.4 0.3 0.11 13.4 0.3 2.6 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain PDZ PF00595.24 PIK43325.1 - 3.5e-05 24.1 0.0 9.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK43325.1 - 0.00032 20.5 0.0 0.00091 19.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK43325.1 - 0.042 14.2 0.0 0.12 12.7 0.0 1.7 1 1 0 1 1 1 0 PDZ domain IL1 PF00340.19 PIK43325.1 - 0.097 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Interleukin-1 / 18 DUF3972 PF13118.6 PIK43325.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) PDZ_6 PF17820.1 PIK43326.1 - 8.6e-06 25.5 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK43326.1 - 0.00021 21.6 0.0 0.0004 20.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK43326.1 - 0.0025 18.1 0.1 0.021 15.1 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK43327.1 - 3.4e-06 27.3 0.0 6.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain RVT_1 PF00078.27 PIK43327.1 - 6.4e-05 22.6 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDZ PF00595.24 PIK43327.1 - 0.00015 22.0 0.0 0.00028 21.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Caldesmon PF02029.15 PIK43327.1 - 0.019 13.7 1.6 0.9 8.2 0.0 2.1 2 0 0 2 2 2 0 Caldesmon COesterase PF00135.28 PIK43328.1 - 2.8e-150 501.6 0.0 3.2e-150 501.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK43328.1 - 3.9e-07 30.1 0.1 6.7e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2642 PF10842.8 PIK43328.1 - 0.034 14.0 0.1 0.064 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) zf-C3HC4 PF00097.25 PIK43329.1 - 5.7e-10 38.9 10.3 5.7e-10 38.9 10.3 4.0 5 0 0 5 5 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK43329.1 - 1.7e-08 34.4 7.3 1.7e-08 34.4 7.3 3.7 3 1 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK43329.1 - 8.4e-08 32.2 9.7 8.4e-08 32.2 9.7 4.0 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK43329.1 - 9.8e-08 31.7 10.4 9.8e-08 31.7 10.4 4.6 4 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK43329.1 - 1.5e-07 31.2 7.1 1.5e-07 31.2 7.1 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK43329.1 - 3.4e-07 30.3 7.5 3.4e-07 30.3 7.5 4.5 6 0 0 6 6 6 2 B-box zinc finger zf-RING_2 PF13639.6 PIK43329.1 - 5.4e-07 29.8 8.8 5.4e-07 29.8 8.8 4.1 4 0 0 4 4 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK43329.1 - 1.2e-05 25.2 8.1 1.2e-05 25.2 8.1 4.5 4 1 0 4 4 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK43329.1 - 0.00087 19.1 8.1 0.00087 19.1 8.1 3.7 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 PIK43329.1 - 0.0086 15.9 3.2 0.0086 15.9 3.2 2.8 3 0 0 3 3 2 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 PIK43329.1 - 0.01 15.6 4.7 0.067 12.9 4.7 2.6 1 0 0 1 1 1 0 RING-like zinc finger DUF2524 PF10732.9 PIK43329.1 - 0.096 13.0 3.2 0.092 13.1 1.4 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2524) CREPT PF16566.5 PIK43329.1 - 0.19 11.9 6.9 28 4.9 0.0 3.3 4 0 0 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour Apolipoprotein PF01442.18 PIK43329.1 - 0.3 10.9 6.2 1.5 8.6 6.2 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain zf-ANAPC11 PF12861.7 PIK43329.1 - 5.1 7.2 9.4 0.66 10.1 1.5 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4303 PF14136.6 PIK43329.1 - 8.4 6.1 7.4 1.6 8.4 2.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4303) ShK PF01549.24 PIK43331.1 - 2.7e-51 171.8 110.3 7.6e-09 36.0 8.3 8.4 8 0 0 8 8 8 8 ShK domain-like Astacin PF01400.24 PIK43331.1 - 2.2e-43 148.1 0.7 4.6e-43 147.1 0.7 1.5 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) EamA PF00892.20 PIK43332.1 - 0.00019 21.6 14.6 0.00047 20.3 14.6 1.6 1 1 0 1 1 1 1 EamA-like transporter family DUF3566 PF12089.8 PIK43332.1 - 0.026 14.9 2.7 0.026 14.9 2.7 1.5 2 0 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) DUF4094 PF13334.6 PIK43332.1 - 0.34 11.4 5.0 0.28 11.6 0.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) GTP1_OBG PF01018.22 PIK43333.1 - 4e-49 166.2 9.8 5.3e-49 165.8 9.8 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 PIK43333.1 - 1.8e-23 82.8 0.0 4e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK43333.1 - 3.1e-11 43.1 0.0 3.4e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK43333.1 - 0.057 13.5 0.0 8.2 6.4 0.0 2.6 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 PIK43333.1 - 0.093 13.0 0.0 14 5.9 0.0 2.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Adaptin_N PF01602.20 PIK43334.1 - 3.6e-137 458.1 10.3 4.2e-137 457.9 10.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 PIK43334.1 - 5.1e-29 100.8 0.2 1.4e-28 99.4 0.2 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 PIK43334.1 - 1.8e-11 44.3 6.3 3e-07 30.6 0.3 3.0 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK43334.1 - 0.0018 18.6 0.0 5 7.6 0.0 3.9 2 1 1 3 3 3 2 HEAT repeats IL13 PF03487.13 PIK43334.1 - 0.0031 17.3 0.5 0.029 14.1 0.4 2.6 2 1 0 2 2 2 1 Interleukin-13 HEAT PF02985.22 PIK43334.1 - 0.04 14.2 4.4 3.7 8.1 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat Vac14_Fab1_bd PF12755.7 PIK43334.1 - 0.26 11.9 2.4 4.1 8.1 0.1 3.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region DUF5578 PF17741.1 PIK43334.1 - 1.1 8.6 6.4 0.29 10.5 0.1 2.9 3 1 0 3 3 3 0 Family of unknown function (DUF5578) PAP_assoc PF03828.19 PIK43335.1 - 5.1e-11 42.6 0.4 1e-10 41.7 0.4 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase FAM219A PF15260.6 PIK43335.1 - 0.011 16.1 3.3 0.019 15.3 3.3 1.3 1 0 0 1 1 1 0 Protein family FAM219A AF-4 PF05110.13 PIK43335.1 - 1.5 6.8 11.8 2 6.4 11.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein GFO_IDH_MocA PF01408.22 PIK43337.1 - 2.3e-18 67.2 0.0 4e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK43337.1 - 6.2e-06 26.2 0.0 1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 PIK43337.1 - 0.00089 19.8 0.0 0.0016 19.0 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 PIK43337.1 - 0.0069 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_3 PF03447.16 PIK43337.1 - 0.0094 16.6 0.0 0.014 16.0 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain adh_short PF00106.25 PIK43340.1 - 7.3e-50 169.1 0.0 8.8e-50 168.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK43340.1 - 1.7e-34 119.4 0.0 2.4e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK43340.1 - 9.8e-18 64.7 0.0 1.3e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK43340.1 - 0.034 13.6 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 PIK43340.1 - 0.23 10.5 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain zf-CCCH_4 PF18044.1 PIK43341.1 - 3.9e-07 29.7 3.4 8.2e-07 28.7 3.4 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 PIK43341.1 - 1.9e-06 27.7 5.4 1.9e-06 27.7 5.4 1.9 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 PIK43341.1 - 7e-06 25.8 1.7 1.4e-05 24.9 1.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 PIK43341.1 - 0.56 10.8 7.4 0.24 11.9 4.8 1.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Nucleoporin_FG PF13634.6 PIK43341.1 - 3.4 8.6 65.9 6.2e+03 -1.9 45.6 4.5 2 2 0 2 2 2 0 Nucleoporin FG repeat region Y_Y_Y PF07495.13 PIK43342.1 - 5e-08 32.8 0.0 0.16 12.0 0.0 3.4 3 0 0 3 3 3 2 Y_Y_Y domain MANEC PF07502.14 PIK43342.1 - 7e-05 23.0 4.1 0.00019 21.6 4.1 1.7 1 0 0 1 1 1 1 MANEC domain DUF5013 PF16405.5 PIK43342.1 - 0.0016 18.7 0.0 6.1 7.1 0.0 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF5013) TcfC PF16967.5 PIK43342.1 - 0.02 14.3 0.1 1.5 8.4 0.0 3.2 3 0 0 3 3 3 0 E-set like domain He_PIG PF05345.12 PIK43342.1 - 0.023 14.9 0.1 61 3.9 0.0 3.6 3 0 0 3 3 3 0 Putative Ig domain DUF4998 PF16389.5 PIK43342.1 - 0.057 13.0 0.0 8.6 5.9 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function Cupredoxin_1 PF13473.6 PIK43342.1 - 0.11 12.7 2.4 13 5.9 0.0 4.0 2 2 0 3 3 3 0 Cupredoxin-like domain UPF0506 PF11703.8 PIK43342.1 - 0.59 10.6 5.3 1.1 9.7 5.3 1.3 1 0 0 1 1 1 0 UPF0506 REJ PF02010.15 PIK43343.1 - 9.1e-05 21.4 0.7 0.00033 19.6 0.7 1.7 1 1 0 1 1 1 1 REJ domain Y_Y_Y PF07495.13 PIK43343.1 - 0.00013 21.8 0.0 0.025 14.5 0.0 2.5 2 0 0 2 2 2 1 Y_Y_Y domain Cadherin_5 PF17892.1 PIK43343.1 - 0.0008 19.3 1.6 0.21 11.6 0.2 2.6 2 0 0 2 2 2 2 Cadherin-like domain DUF4998 PF16389.5 PIK43343.1 - 0.0055 16.3 0.2 1.2 8.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function EGF_2 PF07974.13 PIK43343.1 - 0.02 15.3 7.8 0.054 13.9 7.8 1.7 1 0 0 1 1 1 0 EGF-like domain He_PIG PF05345.12 PIK43343.1 - 0.03 14.5 4.8 1.5 9.0 2.7 2.5 2 0 0 2 2 2 0 Putative Ig domain DUF4625 PF15418.6 PIK43343.1 - 0.055 13.7 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) PKD PF00801.20 PIK43343.1 - 0.065 13.1 1.9 7.4 6.5 0.1 2.6 2 1 0 2 2 2 0 PKD domain Gamma-thionin PF00304.20 PIK43343.1 - 0.13 12.5 6.5 0.27 11.5 6.5 1.5 1 0 0 1 1 1 0 Gamma-thionin family Big_9 PF17963.1 PIK43343.1 - 0.84 10.4 12.1 1.4 9.7 0.4 3.0 4 0 0 4 4 3 0 Bacterial Ig domain DUF5011 PF16403.5 PIK43343.1 - 1.1 9.4 4.1 5.1 7.3 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) HYR PF02494.16 PIK43344.1 - 3.1e-44 149.2 9.8 2.9e-15 56.4 0.2 3.4 3 0 0 3 3 3 3 HYR domain EGF PF00008.27 PIK43344.1 - 0.00015 22.0 4.8 0.00036 20.8 4.8 1.6 1 0 0 1 1 1 1 EGF-like domain DUF5011 PF16403.5 PIK43344.1 - 0.018 15.2 0.4 12 6.1 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) SEA PF01390.20 PIK43344.1 - 0.025 14.6 0.0 8.7 6.5 0.0 2.6 2 0 0 2 2 2 0 SEA domain EGF_2 PF07974.13 PIK43344.1 - 0.026 14.9 8.5 0.059 13.7 8.5 1.6 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 PIK43344.1 - 0.058 14.0 4.0 0.19 12.4 4.0 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK43344.1 - 0.095 13.0 6.7 0.36 11.2 6.7 1.9 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 PIK43344.1 - 0.47 10.6 8.0 1.1 9.4 8.0 1.6 1 0 0 1 1 1 0 Laminin EGF domain HYR PF02494.16 PIK43345.1 - 2.5e-67 223.2 25.5 5e-22 78.0 1.0 4.0 4 0 0 4 4 4 4 HYR domain DUF5011 PF16403.5 PIK43345.1 - 7.6e-08 32.4 6.0 0.062 13.4 1.1 4.3 4 0 0 4 4 4 3 Domain of unknown function (DUF5011) Big_9 PF17963.1 PIK43345.1 - 0.021 15.5 10.7 0.021 15.5 10.7 4.3 1 1 3 4 4 4 0 Bacterial Ig domain DUF4426 PF14467.6 PIK43345.1 - 0.052 13.5 0.0 0.73 9.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4426) DUF1833 PF08875.11 PIK43345.1 - 0.14 11.7 2.3 2.4 7.7 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1833) Spindle_Spc25 PF08234.12 PIK43345.1 - 0.16 12.2 0.0 3.5 7.9 0.0 2.7 3 0 0 3 3 3 0 Chromosome segregation protein Spc25 DUF756 PF05506.12 PIK43345.1 - 0.16 12.9 0.4 9 7.3 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF756) Cadherin_5 PF17892.1 PIK43345.1 - 0.69 9.9 14.7 0.33 10.9 1.9 4.0 4 0 0 4 4 4 0 Cadherin-like domain HYR PF02494.16 PIK43346.1 - 8.1e-44 147.9 16.2 5.2e-17 61.9 2.2 3.0 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK43346.1 - 0.015 15.4 0.7 7.8 6.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) zf-RING_UBOX PF13445.6 PIK43347.1 - 3.7e-09 36.5 11.9 6.3e-09 35.7 6.3 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK43347.1 - 3.4e-07 30.3 9.8 3.4e-07 30.3 9.8 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK43347.1 - 4.2e-07 29.7 7.4 4.2e-07 29.7 7.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK43347.1 - 6.4e-07 29.1 7.8 6.4e-07 29.1 7.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK43347.1 - 6e-05 23.3 7.3 6e-05 23.3 7.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK43347.1 - 0.00039 20.2 6.1 0.00039 20.2 6.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK43347.1 - 0.00062 19.9 7.1 0.00062 19.9 7.1 2.6 4 0 0 4 4 4 1 B-box zinc finger zf-RING_5 PF14634.6 PIK43347.1 - 0.0016 18.4 6.8 0.0016 18.4 6.8 2.9 2 1 0 2 2 2 1 zinc-RING finger domain IBR PF01485.21 PIK43347.1 - 4.5 7.6 19.1 0.4 10.9 5.9 2.9 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain DAGK_acc PF00609.19 PIK43348.1 - 2.8e-53 180.5 0.0 4.7e-53 179.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 PIK43348.1 - 1.3e-24 86.2 0.0 2.6e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.23 PIK43348.1 - 1.7e-11 44.6 0.0 4.9e-11 43.1 0.0 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Methyltransf_16 PF10294.9 PIK43349.1 - 2.1e-09 37.4 0.0 2.5e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_16 PF10294.9 PIK43350.1 - 4.6e-16 59.0 0.2 5.1e-16 58.9 0.2 1.1 1 0 0 1 1 1 1 Lysine methyltransferase GutM PF06923.11 PIK43350.1 - 0.042 14.0 0.0 0.058 13.5 0.0 1.2 1 0 0 1 1 1 0 Glucitol operon activator protein (GutM) MTS PF05175.14 PIK43350.1 - 0.063 12.8 0.1 0.1 12.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Ku PF02735.16 PIK43351.1 - 1.3e-42 145.8 0.0 2.5e-42 144.9 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 PIK43351.1 - 2.1e-33 115.0 3.7 2.1e-33 115.0 3.7 1.9 2 0 0 2 2 2 1 Ku C terminal domain like Ku_N PF03731.15 PIK43351.1 - 3.5e-23 82.5 0.0 1.2e-22 80.8 0.0 1.9 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 PIK43351.1 - 2.1e-11 44.3 2.5 9.6e-11 42.2 0.1 3.0 3 0 0 3 3 3 1 Ku70/Ku80 C-terminal arm Pkinase_Tyr PF07714.17 PIK43352.1 - 1.2e-52 178.8 0.0 1.3e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43352.1 - 1e-22 80.8 0.0 1.3e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 PIK43352.1 - 0.0035 16.3 0.0 0.0044 16.0 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK43352.1 - 0.0059 16.0 0.0 0.0073 15.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Peptidase_M15_3 PF08291.11 PIK43354.1 - 0.0054 16.8 0.1 0.0096 16.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase M15 Phage_int_SAM_4 PF13495.6 PIK43356.1 - 3.4e-06 27.4 0.0 6.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK43356.1 - 0.0027 18.0 0.3 0.0083 16.4 0.0 1.9 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK43357.1 - 0.00017 22.0 0.0 0.00039 20.8 0.0 1.7 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK43357.1 - 0.00019 21.6 0.6 0.00039 20.7 0.5 1.6 1 1 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain ISP3_C PF18045.1 PIK43358.1 - 0.019 14.8 0.1 0.055 13.3 0.1 1.8 1 0 0 1 1 1 0 ISP3 C-terminal ZU5 PF00791.20 PIK43360.1 - 6.3e-13 48.9 0.1 1.2e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain RVT_1 PF00078.27 PIK43361.1 - 6.4e-28 97.8 0.5 8.9e-28 97.3 0.5 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TraT PF05818.12 PIK43361.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF4767 PF15983.5 PIK43362.1 - 0.073 13.3 0.8 0.11 12.7 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4767) adh_short PF00106.25 PIK43363.1 - 9e-51 172.1 0.7 1.1e-50 171.8 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK43363.1 - 1.9e-32 112.7 0.3 2.3e-32 112.4 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK43363.1 - 2.4e-12 47.1 0.2 3.5e-12 46.6 0.2 1.1 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 PIK43363.1 - 0.0044 16.4 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 PIK43363.1 - 0.0055 16.2 0.1 0.0095 15.4 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK43363.1 - 0.0065 15.6 0.3 0.013 14.6 0.2 1.7 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein ApbA PF02558.16 PIK43363.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF1776 PF08643.10 PIK43363.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF2525 PF10733.9 PIK43363.1 - 0.15 12.3 0.1 1.1 9.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2525) Pecanex_C PF05041.15 PIK43364.1 - 1.4e-28 100.0 0.0 1.8e-28 99.7 0.0 1.0 1 0 0 1 1 1 1 Pecanex protein (C-terminus) Rad51 PF08423.11 PIK43366.1 - 8e-130 431.6 0.1 9.6e-130 431.4 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 PIK43366.1 - 6.3e-11 42.2 0.0 9.1e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 PIK43366.1 - 2.2e-10 40.5 0.1 4.2e-10 39.5 0.1 1.3 1 1 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 PIK43366.1 - 4.6e-08 33.6 0.0 1.2e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 PIK43366.1 - 1.8e-05 24.2 1.9 0.00032 20.1 1.9 2.3 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 PIK43366.1 - 0.0031 16.9 0.1 0.2 10.9 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_28 PF13521.6 PIK43366.1 - 0.0031 17.8 1.0 0.012 15.9 0.1 2.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 PIK43366.1 - 0.0065 16.7 0.0 0.018 15.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain HHH PF00633.23 PIK43366.1 - 0.04 13.8 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif ssDNA_TraI_N PF18272.1 PIK43366.1 - 0.076 13.0 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain ATP-synt_ab PF00006.25 PIK43366.1 - 0.1 12.2 0.1 0.22 11.1 0.1 1.7 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain E1_dh PF00676.20 PIK43367.1 - 9.2e-100 333.4 0.1 1.1e-99 333.1 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 PIK43367.1 - 0.00055 19.0 0.0 0.00074 18.6 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain TPP_enzyme_C PF02775.21 PIK43367.1 - 0.0019 18.0 0.5 0.015 15.0 0.4 2.1 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 PIK43367.1 - 0.0066 15.7 0.0 0.037 13.2 0.0 1.9 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Tmem26 PF09772.9 PIK43368.1 - 4.4e-71 239.6 2.9 5.2e-71 239.3 2.9 1.0 1 0 0 1 1 1 1 Transmembrane protein 26 GWT1 PF06423.12 PIK43368.1 - 0.026 14.6 0.0 0.11 12.6 0.0 2.1 1 1 0 1 1 1 0 GWT1 Flp_N PF03930.14 PIK43368.1 - 0.16 12.0 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus Cystatin PF00031.21 PIK43369.1 - 4.4e-19 68.5 0.8 5.5e-19 68.2 0.8 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 PIK43369.1 - 1e-11 45.0 1.4 4e-07 30.3 0.2 2.2 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor Dodecin PF07311.12 PIK43369.1 - 0.014 15.6 0.3 0.025 14.8 0.3 1.3 1 0 0 1 1 1 0 Dodecin RNA_pol_Rpc34 PF05158.12 PIK43370.1 - 3.1e-82 276.7 0.0 6e-82 275.7 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_24 PF13412.6 PIK43370.1 - 0.00041 19.8 0.1 0.0019 17.7 0.1 2.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF4821 PF16092.5 PIK43371.1 - 5.9e-50 170.3 0.6 4e-44 151.2 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4821) FOP_dimer PF09398.10 PIK43371.1 - 0.12 12.6 1.6 0.18 12.0 0.3 2.0 2 0 0 2 2 2 0 FOP N terminal dimerisation domain Ricin_B_lectin PF00652.22 PIK43372.1 - 3.3e-19 69.4 2.0 5.5e-19 68.7 2.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Exo_endo_phos PF03372.23 PIK43373.1 - 3.5e-18 66.0 0.1 7.6e-18 64.9 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Sulfotransfer_1 PF00685.27 PIK43374.1 - 3.5e-12 46.4 0.1 6e-12 45.6 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK43374.1 - 3.6e-07 30.8 0.3 0.0039 17.6 0.1 3.2 1 1 1 2 2 2 2 Sulfotransferase family Tetraspanin PF00335.20 PIK43375.1 - 5e-34 118.0 14.1 9.8e-34 117.0 14.1 1.5 1 1 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 PIK43375.1 - 0.012 15.7 5.7 0.012 15.7 5.7 2.4 2 1 0 2 2 2 0 CD20-like family Phage_holin_3_6 PF07332.11 PIK43375.1 - 0.02 14.9 3.1 0.97 9.5 0.5 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Rax2 PF12768.7 PIK43375.1 - 0.023 14.1 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 Cortical protein marker for cell polarity NAD_binding_4 PF07993.12 PIK43376.1 - 1.3e-76 257.2 0.0 1.8e-76 256.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 PIK43376.1 - 8.4e-23 80.4 3.4 1.5e-22 79.6 0.1 2.7 3 0 0 3 3 3 1 Male sterility protein Epimerase PF01370.21 PIK43376.1 - 7.9e-06 25.5 0.0 6.2e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK43376.1 - 0.00079 18.6 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 PIK43376.1 - 0.0025 16.9 1.3 0.045 12.7 0.7 2.7 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 PIK43376.1 - 0.0035 16.8 0.6 0.054 12.9 0.5 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK43377.1 - 7.7e-78 261.2 0.0 1e-77 260.8 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 PIK43377.1 - 3.5e-27 94.5 0.2 9.9e-27 93.0 0.2 1.8 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 PIK43377.1 - 0.00086 18.5 0.0 0.002 17.3 0.0 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 PIK43377.1 - 0.0027 16.8 0.8 0.049 12.6 0.3 2.8 2 2 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK43377.1 - 0.014 14.8 0.1 0.15 11.5 0.1 2.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK43377.1 - 0.13 11.6 0.0 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase RNA_pol_N PF01194.17 PIK43378.1 - 3.9e-34 116.7 0.2 4.4e-34 116.6 0.2 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 PIK43378.1 - 0.035 14.4 0.2 0.048 13.9 0.2 1.3 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) DUF2838 PF10998.8 PIK43379.1 - 0.049 13.9 1.8 0.049 13.9 1.8 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2838) Fun_ATP-synt_8 PF05933.13 PIK43379.1 - 0.15 12.2 0.2 0.15 12.2 0.2 2.5 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) Reticulon PF02453.17 PIK43379.1 - 1.2 9.1 9.5 21 5.1 9.5 2.2 1 1 0 1 1 1 0 Reticulon DUF3099 PF11298.8 PIK43379.1 - 2.8 8.1 4.8 1.5 9.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) Ets PF00178.22 PIK43380.1 - 5.7e-37 126.0 1.1 1.1e-36 125.1 1.1 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 PIK43380.1 - 3.2e-28 97.5 0.1 6e-28 96.7 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain HSF_DNA-bind PF00447.17 PIK43380.1 - 0.11 13.2 0.0 0.29 11.8 0.0 1.8 1 0 0 1 1 1 0 HSF-type DNA-binding Ets PF00178.22 PIK43381.1 - 6.1e-22 77.9 0.8 9.2e-22 77.3 0.8 1.3 1 0 0 1 1 1 1 Ets-domain Cu-oxidase_2 PF07731.14 PIK43384.1 - 7.1e-27 93.8 0.4 9.9e-27 93.3 0.4 1.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK43385.1 - 1.1e-36 125.4 0.1 2e-36 124.6 0.1 1.3 1 0 0 1 1 1 1 Multicopper oxidase SRCR PF00530.18 PIK43385.1 - 1.1e-33 115.7 2.2 5.5e-27 94.2 3.2 2.4 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Cu-oxidase_2 PF07731.14 PIK43385.1 - 2.3e-06 27.4 0.6 1.1e-05 25.2 0.6 2.0 1 1 0 1 1 1 1 Multicopper oxidase SRCR_2 PF15494.6 PIK43385.1 - 3.4e-05 24.3 0.5 7.6e-05 23.2 0.5 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Peptidase_S74 PF13884.6 PIK43385.1 - 0.18 12.1 0.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 Chaperone of endosialidase SRCR PF00530.18 PIK43386.1 - 1.3e-49 166.9 12.0 1.5e-26 92.8 4.2 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK43386.1 - 2.9e-11 43.8 6.5 4.2e-05 24.0 0.2 2.4 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK43386.1 - 8.3e-06 26.3 0.1 0.14 12.6 0.0 2.3 2 0 0 2 2 2 2 Hepsin, SRCR domain YecR PF13992.6 PIK43386.1 - 0.00035 20.8 2.1 0.65 10.3 0.2 2.5 2 0 0 2 2 2 2 YecR-like lipoprotein SDH_alpha PF03313.15 PIK43386.1 - 0.0026 17.5 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 2 Serine dehydratase alpha chain PRKCSH-like PF12999.7 PIK43386.1 - 0.02 14.7 2.7 0.55 10.0 1.5 2.3 2 0 0 2 2 2 0 Glucosidase II beta subunit-like PapJ PF14855.6 PIK43386.1 - 0.12 12.1 0.0 5.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Pilus-assembly fibrillin subunit, chaperone SRCR PF00530.18 PIK43387.1 - 1.9e-53 179.1 10.2 2.9e-29 101.5 3.0 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK43387.1 - 8.7e-11 42.2 3.2 3.5e-05 24.3 0.4 2.7 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK43387.1 - 0.00059 20.3 0.1 0.76 10.3 0.1 3.0 2 1 0 2 2 2 2 Hepsin, SRCR domain Gly_rich_SFCGS PF14272.6 PIK43387.1 - 0.086 12.9 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Glycine-rich SFCGS SRCR PF00530.18 PIK43388.1 - 1.3e-20 73.7 0.7 1.4e-20 73.6 0.7 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK43388.1 - 7.4e-06 26.4 1.2 9e-06 26.2 0.3 1.6 1 1 1 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK43388.1 - 0.041 14.4 0.1 0.074 13.6 0.0 1.5 1 1 1 2 2 2 0 Hepsin, SRCR domain SRCR PF00530.18 PIK43389.1 - 4.9e-86 283.7 17.2 2.7e-29 101.6 2.5 4.0 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK43389.1 - 2.1e-17 63.4 1.3 1.9e-05 25.1 0.1 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK43389.1 - 4.9e-07 30.3 0.0 0.49 10.9 0.0 3.3 3 0 0 3 3 3 2 Hepsin, SRCR domain YecR PF13992.6 PIK43389.1 - 5.8e-05 23.3 2.1 0.25 11.7 0.4 3.0 2 0 0 2 2 2 2 YecR-like lipoprotein C9orf72-like PF15019.6 PIK43390.1 - 0.022 14.3 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 C9orf72-like protein family PSRP-3_Ycf65 PF04839.13 PIK43390.1 - 0.38 11.0 2.6 8.7 6.6 0.3 2.4 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) TIMP PF00965.17 PIK43391.1 - 1.3e-25 90.3 9.5 3.2e-25 89.0 9.5 1.6 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK43391.1 - 0.00047 19.9 0.0 0.15 11.9 0.0 2.5 2 0 0 2 2 2 2 UNC-6/NTR/C345C module Kunitz_BPTI PF00014.23 PIK43392.1 - 2.4e-118 386.3 82.7 1.9e-18 66.4 5.9 8.7 7 0 0 7 7 7 7 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3265 PF11665.8 PIK43392.1 - 0.0049 17.1 15.9 60 4.0 0.0 7.5 7 0 0 7 7 7 0 Protein of unknown function (DUF3265) CDI PF02234.19 PIK43392.1 - 0.14 12.4 0.0 53 4.1 0.0 3.3 3 0 0 3 3 3 0 Cyclin-dependent kinase inhibitor zf-RING_2 PF13639.6 PIK43394.1 - 3.8e-10 39.9 12.7 1e-09 38.6 12.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 PIK43394.1 - 2e-09 37.6 9.8 5.8e-09 36.1 9.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK43394.1 - 2.9e-06 27.1 13.0 5.9e-06 26.0 13.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK43394.1 - 5.2e-06 26.2 12.0 1.1e-05 25.2 12.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK43394.1 - 9.9e-06 25.5 8.1 2.3e-05 24.3 8.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK43394.1 - 8.4e-05 22.3 9.4 0.00021 21.1 9.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 PIK43394.1 - 9.8e-05 21.9 5.9 9.8e-05 21.9 5.9 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 PIK43394.1 - 0.00045 20.1 11.4 0.0012 18.8 11.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK43394.1 - 0.0026 17.8 8.8 0.077 13.1 8.8 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.6 PIK43394.1 - 0.0028 17.9 3.3 0.007 16.6 3.3 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain Prok-RING_4 PF14447.6 PIK43394.1 - 0.0034 17.2 8.4 0.0064 16.3 8.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK43394.1 - 0.0047 16.6 7.5 0.0047 16.6 7.5 1.9 2 0 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.8 PIK43394.1 - 0.0063 16.7 5.5 0.015 15.4 5.5 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING-like PF08746.11 PIK43394.1 - 0.18 12.1 11.4 0.41 11.0 11.4 1.6 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 PIK43394.1 - 0.28 11.3 4.5 0.64 10.2 4.5 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger RINGv PF12906.7 PIK43394.1 - 1.8 8.8 11.0 4.6 7.5 11.0 1.6 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 PIK43394.1 - 3.5 7.8 10.5 0.89 9.6 6.9 2.0 2 0 0 2 2 2 0 Zinc-finger Laminin_G_2 PF02210.24 PIK43395.1 - 1e-68 229.7 8.6 2.6e-25 89.5 0.1 3.2 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 PIK43395.1 - 1.2e-59 200.2 1.8 6.4e-21 74.9 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.6 PIK43395.1 - 1.6e-10 41.3 2.4 0.0032 17.6 0.1 3.4 3 1 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.11 PIK43395.1 - 1e-05 25.8 0.7 0.14 12.3 0.0 3.3 3 1 1 4 4 4 2 Domain of Unknown Function (DUF1080) EGF PF00008.27 PIK43395.1 - 7e-05 23.1 5.6 0.00013 22.2 5.6 1.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK43395.1 - 0.0082 16.8 3.2 0.029 15.0 3.2 2.0 1 0 0 1 1 1 1 Human growth factor-like EGF Laminin_G_2 PF02210.24 PIK43396.1 - 1.7e-47 161.1 0.1 7.7e-23 81.4 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK43396.1 - 4.3e-31 107.9 0.0 8e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 PIK43396.1 - 9.2e-05 22.7 3.0 0.00018 21.7 3.0 1.5 1 0 0 1 1 1 1 EGF-like domain Guanylate_cyc PF00211.20 PIK43397.1 - 1e-06 28.5 0.0 1.4e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain GAS PF13851.6 PIK43398.1 - 1.2e-85 285.9 28.9 1.2e-85 285.9 28.9 3.0 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK43398.1 - 0.0071 15.3 20.1 0.0071 15.3 20.1 3.9 1 1 3 4 4 4 2 Spc7 kinetochore protein DUF724 PF05266.14 PIK43398.1 - 0.0097 15.7 15.2 0.0097 15.7 15.2 4.9 2 2 3 5 5 5 1 Protein of unknown function (DUF724) Baculo_PEP_C PF04513.12 PIK43398.1 - 0.18 11.9 14.7 0.63 10.1 2.1 4.0 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 PIK43398.1 - 0.53 10.6 12.1 4.8 7.5 0.1 4.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GCV_H PF01597.19 PIK43399.1 - 2.7e-44 149.9 0.1 3.3e-44 149.7 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 PIK43399.1 - 0.00045 20.0 0.3 0.00073 19.3 0.3 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 PIK43399.1 - 0.0098 15.8 0.1 0.014 15.3 0.1 1.2 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Chromo PF00385.24 PIK43400.1 - 3.7e-15 55.6 0.2 5.6e-15 55.0 0.2 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 PIK43400.1 - 0.0031 17.4 0.0 0.0067 16.3 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF5305 PF17231.2 PIK43400.1 - 0.053 12.9 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) WD40 PF00400.32 PIK43401.1 - 3e-43 145.0 29.1 7.4e-09 36.1 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43401.1 - 1.8e-10 40.9 4.7 0.023 15.0 0.0 5.4 1 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK43401.1 - 2.1e-05 24.0 2.4 0.19 11.0 0.1 3.1 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 PIK43401.1 - 7.6e-05 21.8 1.3 2.4 7.0 0.1 4.1 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Me-amine-dh_H PF06433.11 PIK43401.1 - 0.028 13.3 0.1 0.11 11.4 0.0 2.0 2 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) IBN_N PF03810.19 PIK43402.1 - 4.9e-15 55.2 6.3 3.1e-14 52.6 0.9 4.5 4 0 0 4 4 4 1 Importin-beta N-terminal domain HEAT PF02985.22 PIK43402.1 - 9.5e-13 47.2 5.8 0.015 15.5 0.0 9.0 10 0 0 10 10 9 2 HEAT repeat HEAT_EZ PF13513.6 PIK43402.1 - 2.5e-12 47.0 13.8 4.2e-05 24.0 0.0 9.3 10 3 3 13 13 12 3 HEAT-like repeat RIX1 PF08167.12 PIK43402.1 - 6.2e-11 42.4 3.6 0.016 14.9 0.1 5.9 4 3 1 5 5 5 3 rRNA processing/ribosome biogenesis HEAT_2 PF13646.6 PIK43402.1 - 2.8e-08 34.1 0.3 3.5 8.1 0.0 7.4 7 2 1 9 9 9 2 HEAT repeats RTP1_C1 PF10363.9 PIK43402.1 - 1.1e-06 28.8 1.8 1 9.6 0.0 6.6 6 2 2 8 8 8 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 PIK43402.1 - 1.6e-05 24.9 8.0 0.41 10.5 0.0 6.2 3 3 1 4 4 4 2 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 PIK43402.1 - 7.3e-05 23.3 2.4 7.7 7.2 0.0 6.7 6 2 1 9 9 9 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK43402.1 - 0.00031 20.4 3.3 3.3 7.2 0.0 5.5 4 2 1 5 5 5 1 CLASP N terminal Xpo1 PF08389.12 PIK43402.1 - 0.00076 19.6 6.5 0.78 9.8 0.0 5.5 5 1 0 5 5 5 1 Exportin 1-like protein TAF6_C PF07571.13 PIK43402.1 - 0.01 16.1 0.4 11 6.5 0.0 4.3 4 1 1 5 5 5 0 TAF6 C-terminal HEAT repeat domain DUF3361 PF11841.8 PIK43402.1 - 0.45 10.4 4.2 12 5.8 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) PX PF00787.24 PIK43403.1 - 1.8e-18 66.5 0.0 3e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 PX domain DUF641 PF04859.12 PIK43403.1 - 0.0035 17.7 0.0 0.0048 17.2 0.0 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) DHR10 PF18595.1 PIK43403.1 - 0.017 15.2 2.6 0.026 14.6 2.6 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain SlyX PF04102.12 PIK43403.1 - 0.019 15.5 0.3 0.08 13.6 0.4 2.0 2 0 0 2 2 2 0 SlyX RVT_1 PF00078.27 PIK43404.1 - 9.9e-38 129.9 0.1 1.5e-37 129.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YidD PF01809.18 PIK43404.1 - 0.014 15.3 0.3 0.032 14.1 0.3 1.6 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor RVT_1 PF00078.27 PIK43405.1 - 6.1e-30 104.4 0.1 7.5e-30 104.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4868 PF16162.5 PIK43405.1 - 0.05 13.6 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4868) CTNNBL PF08216.11 PIK43406.1 - 3.7e-37 126.7 2.2 3.7e-37 126.7 2.2 2.0 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 PIK43406.1 - 0.00058 19.8 0.4 1 9.5 0.0 3.5 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF913 PF06025.12 PIK43406.1 - 0.042 12.8 0.8 5.9 5.8 0.0 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) HAND PF09110.11 PIK43406.1 - 0.084 13.6 5.2 0.06 14.1 2.4 2.2 2 0 0 2 2 2 0 HAND GSH_synth_ATP PF03917.17 PIK43407.1 - 6.2e-101 337.9 0.1 1.2e-100 336.9 0.1 1.4 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 PIK43407.1 - 1.1e-14 54.8 0.1 2.7e-14 53.4 0.1 1.7 1 0 0 1 1 1 1 Eukaryotic glutathione synthase F-box-like PF12937.7 PIK43408.1 - 2e-09 37.2 0.2 2e-09 37.2 0.2 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK43408.1 - 1.4e-06 28.0 0.2 1.4e-06 28.0 0.2 2.1 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 PIK43408.1 - 0.019 15.4 2.3 0.33 11.4 0.4 3.3 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK43409.1 - 5.3e-09 35.8 0.1 1.2e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK43409.1 - 2.1e-08 33.8 0.0 8.2e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 F-box domain DUF956 PF06115.11 PIK43409.1 - 0.17 11.6 0.0 0.29 10.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF956) HECT PF00632.25 PIK43410.1 - 5.5e-10 39.2 0.2 6.6e-09 35.7 0.2 2.1 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DZR PF12773.7 PIK43410.1 - 0.012 15.6 3.1 0.034 14.2 3.1 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 PIK43410.1 - 0.038 13.3 3.0 0.073 12.4 3.0 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Spt4 PF06093.13 PIK43410.1 - 0.085 13.0 0.6 0.18 11.9 0.6 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger RecR PF02132.15 PIK43410.1 - 0.29 10.7 2.6 0.76 9.4 2.6 1.6 1 0 0 1 1 1 0 RecR protein RVT_1 PF00078.27 PIK43412.1 - 0.00014 21.5 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_10 PF16588.5 PIK43413.1 - 0.004 16.8 0.6 0.0097 15.6 0.6 1.7 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 PIK43413.1 - 0.035 14.2 11.5 0.069 13.2 0.5 2.9 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43413.1 - 0.049 13.5 3.8 0.049 13.5 3.8 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK43413.1 - 0.061 13.3 1.2 0.061 13.3 1.2 2.8 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43413.1 - 0.063 13.0 4.7 2.5 7.9 0.3 2.4 1 1 1 2 2 2 0 Zinc knuckle MULE PF10551.9 PIK43414.1 - 0.011 16.1 0.1 0.023 15.1 0.1 1.5 1 0 0 1 1 1 0 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 PIK43414.1 - 0.027 14.2 0.8 0.047 13.4 0.3 1.7 2 0 0 2 2 2 0 Transposase Arabinose_Iso_C PF11762.8 PIK43414.1 - 0.081 12.7 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain RVT_1 PF00078.27 PIK43416.1 - 1e-22 80.8 0.0 1.8e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.14 PIK43416.1 - 0.071 13.0 0.0 0.96 9.3 0.0 2.4 2 0 0 2 2 2 0 Reverse transcriptase thumb domain gag-asp_proteas PF13975.6 PIK43416.1 - 0.14 12.7 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF5338 PF17273.2 PIK43417.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5338) Mucin2_WxxW PF13330.6 PIK43418.1 - 3.3e-15 56.7 3.8 8.2e-15 55.4 3.8 1.7 1 0 0 1 1 1 1 Mucin-2 protein WxxW repeating region Mucin2_WxxW PF13330.6 PIK43419.1 - 2.5e-06 28.2 0.4 7.4e-06 26.7 0.4 1.8 1 0 0 1 1 1 1 Mucin-2 protein WxxW repeating region Mucin2_WxxW PF13330.6 PIK43420.1 - 5.2e-45 152.2 21.7 5.9e-13 49.5 2.3 5.0 4 0 0 4 4 4 4 Mucin-2 protein WxxW repeating region MAT1-1-2 PF17043.5 PIK43421.1 - 0.06 13.2 0.7 1.4e+02 2.2 0.0 4.5 2 2 3 5 5 5 0 Mating type protein 1-1-2 of unknown function DUF3583 PF12126.8 PIK43423.1 - 0.42 10.0 6.5 0.68 9.3 6.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) VWD PF00094.25 PIK43426.1 - 1.8e-19 70.5 0.2 2.8e-19 69.9 0.0 1.4 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 PIK43426.1 - 2.8e-15 56.5 8.7 2.8e-15 56.5 8.7 1.8 2 0 0 2 2 2 1 C8 domain VWD PF00094.25 PIK43427.1 - 9.9e-17 61.6 0.0 1.5e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK43427.1 - 8.4e-12 45.4 11.2 8.4e-12 45.4 11.2 2.1 3 0 0 3 3 3 1 C8 domain TIL PF01826.17 PIK43427.1 - 0.004 17.4 12.3 0.004 17.4 12.3 3.8 1 1 1 2 2 2 1 Trypsin Inhibitor like cysteine rich domain HlyD PF00529.20 PIK43428.1 - 9.8 6.1 7.7 5.8 6.9 0.3 3.0 2 1 0 2 2 2 0 HlyD membrane-fusion protein of T1SS Peptidase_M55 PF04951.13 PIK43429.1 - 0.04 13.3 1.1 0.77 9.1 0.3 2.0 1 1 1 2 2 2 0 D-aminopeptidase VWD PF00094.25 PIK43430.1 - 2.4e-79 265.1 5.2 4e-32 111.7 0.9 3.4 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 PIK43430.1 - 4.6e-39 132.7 39.6 8.3e-17 61.4 11.4 8.1 7 3 2 9 9 9 3 C8 domain TIL PF01826.17 PIK43430.1 - 1.2e-18 67.0 88.0 3.2e-09 36.9 16.1 9.5 10 0 0 10 10 10 4 Trypsin Inhibitor like cysteine rich domain Pacifastin_I PF05375.13 PIK43430.1 - 0.0066 16.2 10.6 0.0066 16.2 10.6 7.1 7 0 0 7 7 7 2 Pacifastin inhibitor (LCMII) Forkhead PF00250.18 PIK43431.1 - 2e-38 130.5 0.1 3.9e-38 129.6 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 PIK43431.1 - 0.19 12.1 0.4 0.44 10.9 0.2 1.7 2 0 0 2 2 2 0 linker histone H1 and H5 family DUF4663 PF15668.5 PIK43431.1 - 0.5 9.4 4.7 0.71 8.9 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) DEAD PF00270.29 PIK43432.1 - 2.4e-14 53.5 0.1 5.1e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK43432.1 - 4.9e-11 43.0 0.0 2.2e-09 37.7 0.0 2.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK43432.1 - 1.5e-07 31.6 0.1 4.5e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HHH_5 PF14520.6 PIK43432.1 - 0.00058 20.4 0.2 0.0015 19.1 0.2 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 PIK43432.1 - 0.13 12.5 0.6 0.32 11.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) zf-B_box PF00643.24 PIK43433.1 - 6.8e-08 32.5 6.4 6.8e-08 32.5 6.4 2.3 2 0 0 2 2 2 1 B-box zinc finger NHL PF01436.21 PIK43433.1 - 0.00013 21.8 0.3 0.00073 19.5 0.0 2.5 2 0 0 2 2 2 1 NHL repeat Filamin PF00630.19 PIK43433.1 - 0.00061 20.6 1.2 0.0011 19.8 1.2 1.6 1 1 0 1 1 1 1 Filamin/ABP280 repeat A2L_zn_ribbon PF08792.10 PIK43433.1 - 0.3 10.9 0.1 0.3 10.9 0.1 2.6 2 1 0 2 2 2 0 A2L zinc ribbon domain RNase_P_p30 PF01876.16 PIK43434.1 - 2.2e-52 177.6 0.0 3.1e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 ArAE_1 PF06081.11 PIK43434.1 - 0.16 12.1 0.0 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 SIR2 PF02146.17 PIK43435.1 - 3.5e-12 46.6 0.0 4.6e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Sir2 family PNTB PF02233.16 PIK43435.1 - 0.19 10.6 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit DUF4207 PF13904.6 PIK43438.1 - 0.006 16.3 62.2 0.006 16.3 62.2 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4207) zf-LYAR PF08790.11 PIK43439.1 - 5.9e-15 54.9 9.2 9.1e-15 54.3 2.9 2.6 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-ACC PF17848.1 PIK43439.1 - 0.015 15.4 2.1 0.043 13.9 0.1 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain IBR PF01485.21 PIK43439.1 - 0.2 11.9 7.9 0.61 10.3 7.9 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2 PF00096.26 PIK43439.1 - 0.48 11.0 2.3 18 6.1 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Prok-RING_1 PF14446.6 PIK43439.1 - 0.67 9.9 8.8 2.4 8.1 8.8 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-TRAF PF02176.18 PIK43439.1 - 1.7 9.4 8.0 0.7 10.6 5.1 1.9 2 0 0 2 2 2 0 TRAF-type zinc finger DUF5584 PF17822.1 PIK43439.1 - 2.9 7.3 6.7 3.2 7.1 0.3 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5584) Ank_2 PF12796.7 PIK43440.1 - 6.8e-40 135.5 13.7 1.2e-13 51.4 0.1 4.4 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43440.1 - 6.3e-34 115.9 5.4 2.2e-10 40.8 0.1 6.5 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK43440.1 - 6.4e-32 106.0 7.2 0.00025 21.2 0.0 9.2 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 PIK43440.1 - 9.7e-30 101.7 17.4 6e-06 26.5 0.0 8.4 8 1 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 PIK43440.1 - 4.1e-19 68.4 7.2 2.4e-07 30.9 0.1 6.0 4 2 2 6 6 6 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 PIK43440.1 - 6.3e-07 29.7 1.5 1.7e-06 28.3 1.5 1.7 1 0 0 1 1 1 1 SOCS box Kazal_1 PF00050.21 PIK43441.1 - 3.8e-08 33.2 0.6 7.4e-08 32.3 0.6 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK43441.1 - 9.6e-08 32.0 0.3 9.6e-08 32.0 0.3 2.1 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain 7tm_1 PF00001.21 PIK43442.1 - 1.3e-16 60.7 18.2 2e-16 60.1 18.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FAS_meander PF17951.1 PIK43442.1 - 0.13 12.1 0.3 0.24 11.2 0.3 1.4 1 0 0 1 1 1 0 Fatty acid synthase meander beta sheet domain AAA_25 PF13481.6 PIK43443.1 - 0.00053 19.6 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK43443.1 - 0.0014 18.6 0.0 0.0034 17.3 0.0 1.6 2 0 0 2 2 2 1 NACHT domain DAP3 PF10236.9 PIK43443.1 - 0.035 13.3 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Ploopntkinase3 PF18751.1 PIK43443.1 - 0.089 12.7 1.9 1.3 8.9 0.0 2.7 2 1 1 3 3 3 0 P-loop Nucleotide Kinase3 ASD2 PF08687.11 PIK43443.1 - 0.77 9.3 7.9 1 8.9 7.9 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 ASC PF00858.24 PIK43444.1 - 8.5e-54 183.2 2.7 9.8e-54 183.0 2.7 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel DUF3657 PF12394.8 PIK43444.1 - 0.17 12.5 2.8 0.49 11.0 0.5 2.6 3 0 0 3 3 3 0 Protein FAM135 DDE_Tnp_4 PF13359.6 PIK43445.1 - 1.2e-10 41.3 0.1 1.4e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK43445.1 - 0.00045 19.9 0.0 0.00054 19.6 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein Myb_DNA-bind_5 PF13873.6 PIK43446.1 - 0.0018 18.3 2.0 0.24 11.5 0.1 2.4 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain RVP PF00077.20 PIK43447.1 - 1.6e-06 28.3 0.0 3.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK43447.1 - 0.00068 20.1 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease DUF3666 PF12408.8 PIK43448.1 - 0.094 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribose-5-phosphate isomerase GlutR_dimer PF00745.20 PIK43449.1 - 0.00092 19.6 0.0 0.0034 17.8 0.0 1.9 2 0 0 2 2 2 1 Glutamyl-tRNAGlu reductase, dimerisation domain ORMDL PF04061.14 PIK43449.1 - 0.12 12.2 2.0 0.19 11.6 0.1 2.2 2 1 1 3 3 3 0 ORMDL family JHD PF17811.1 PIK43449.1 - 0.14 12.7 0.4 0.77 10.3 0.0 2.5 3 1 0 3 3 3 0 Jumonji helical domain RT_RNaseH_2 PF17919.1 PIK43450.1 - 4.5e-38 129.3 0.0 6.8e-38 128.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK43450.1 - 1.1e-35 122.0 0.0 2e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK43451.1 - 0.0001 21.9 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YqaJ PF09588.10 PIK43452.1 - 5.7e-14 52.5 0.0 1.1e-13 51.6 0.0 1.5 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Viral_alk_exo PF01771.17 PIK43452.1 - 5.4e-08 32.1 0.3 1.6e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Viral alkaline exonuclease zf-CCCH_7 PF18586.1 PIK43452.1 - 0.049 14.0 0.5 0.13 12.6 0.5 1.7 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 NACHT PF05729.12 PIK43453.1 - 1e-13 51.6 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK43453.1 - 0.0039 16.4 0.1 0.0057 15.9 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK43453.1 - 0.0086 15.7 0.0 0.025 14.2 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 PIK43453.1 - 0.069 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK43453.1 - 0.098 13.2 0.0 0.23 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK43453.1 - 0.19 12.1 0.1 0.44 10.9 0.1 1.7 1 1 1 2 2 2 0 AAA domain Asp_protease_2 PF13650.6 PIK43455.1 - 6.2e-06 26.8 0.2 2.7e-05 24.7 0.1 2.0 1 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK43455.1 - 9.3e-06 26.1 0.2 3.1e-05 24.5 0.1 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease DUF1759 PF03564.15 PIK43455.1 - 9.1e-05 22.4 0.0 0.00035 20.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 PIK43455.1 - 0.00035 20.4 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF1758) CLIP1_ZNF PF16641.5 PIK43455.1 - 0.19 11.6 3.2 0.38 10.7 3.2 1.5 1 0 0 1 1 1 0 CLIP1 zinc knuckle Peptidase_A17 PF05380.13 PIK43456.1 - 1.3e-57 194.3 0.0 1.9e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK43456.1 - 0.0036 16.8 0.0 0.0055 16.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GlutR_dimer PF00745.20 PIK43457.1 - 0.0082 16.6 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain ORMDL PF04061.14 PIK43457.1 - 0.1 12.4 0.1 0.26 11.1 0.1 1.7 1 0 0 1 1 1 0 ORMDL family SMG1_N PF17229.2 PIK43458.1 - 0.05 14.3 0.0 0.053 14.3 0.0 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase SMG1 N-terminal RVT_1 PF00078.27 PIK43459.1 - 1.6e-24 86.7 0.0 2.2e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DPCD PF14913.6 PIK43460.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 DPCD protein family zf-CCHC PF00098.23 PIK43462.1 - 8.9e-09 35.0 9.6 0.00058 19.8 0.2 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43462.1 - 0.001 18.9 9.7 0.15 11.9 4.4 3.2 3 0 0 3 3 3 2 Zinc knuckle zf-C2H2_10 PF16588.5 PIK43462.1 - 0.0021 17.7 4.6 0.021 14.5 0.7 2.6 2 0 0 2 2 2 1 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK43462.1 - 0.005 16.8 12.2 0.42 10.6 1.0 3.4 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43462.1 - 0.02 14.7 0.2 0.02 14.7 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43462.1 - 0.033 13.9 12.2 4.4 7.1 0.4 3.6 2 1 1 3 3 3 0 Zinc knuckle Fibrinogen_C PF00147.18 PIK43463.1 - 1.3e-45 155.9 6.7 1.9e-45 155.4 6.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK43463.1 - 9.3e-05 22.5 4.8 9.3e-05 22.5 4.8 2.2 2 0 0 2 2 2 1 EGF domain EGF_MSP1_1 PF12946.7 PIK43463.1 - 0.0042 17.1 2.8 0.01 15.9 2.8 1.7 1 0 0 1 1 1 1 MSP1 EGF domain 1 Tme5_EGF_like PF09064.10 PIK43463.1 - 0.025 14.4 4.0 0.075 12.9 4.0 1.8 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like COLFI PF01410.18 PIK43463.1 - 0.058 12.7 0.2 0.058 12.7 0.2 1.5 2 0 0 2 2 2 0 Fibrillar collagen C-terminal domain EGF_2 PF07974.13 PIK43463.1 - 0.13 12.6 10.3 0.63 10.5 5.3 3.2 2 0 0 2 2 2 0 EGF-like domain EGF_CA PF07645.15 PIK43463.1 - 1.1 9.5 10.3 1.6 9.0 4.9 2.7 2 0 0 2 2 2 0 Calcium-binding EGF domain Fibrinogen_C PF00147.18 PIK43465.1 - 5.7e-20 72.1 7.1 8.8e-20 71.5 7.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK43465.1 - 2.5e-07 30.8 15.3 2.5e-07 30.8 15.3 1.7 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Glyco_transf_10 PF00852.19 PIK43466.1 - 6e-46 156.4 0.0 9.9e-46 155.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK43466.1 - 2.6e-10 40.7 0.0 5.7e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal NHL PF01436.21 PIK43467.1 - 8.4e-06 25.6 0.3 11 6.3 0.1 5.2 6 0 0 6 6 6 3 NHL repeat SBBP PF06739.11 PIK43467.1 - 0.0046 16.9 0.7 0.016 15.2 0.1 2.2 2 0 0 2 2 2 1 Beta-propeller repeat DUF5128 PF17170.4 PIK43467.1 - 0.057 12.6 6.8 0.2 10.8 0.2 2.6 3 0 0 3 3 3 0 6-bladed beta-propeller NUMOD1 PF07453.13 PIK43467.1 - 0.092 13.0 1.0 12 6.2 0.0 3.2 3 0 0 3 3 3 0 NUMOD1 domain SBBP PF06739.11 PIK43468.1 - 0.0037 17.2 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 Beta-propeller repeat NHL PF01436.21 PIK43468.1 - 0.091 12.8 0.0 15 5.9 0.0 3.8 5 0 0 5 5 5 0 NHL repeat Glyco_transf_10 PF00852.19 PIK43469.1 - 1.8e-41 141.8 0.0 1.9e-41 141.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 PIK43470.1 - 4.9e-47 159.9 0.0 7.6e-47 159.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term p450 PF00067.22 PIK43471.1 - 2.3e-62 211.2 0.0 2.7e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Med25 PF11232.8 PIK43472.1 - 8.1e-35 120.0 0.6 8.1e-35 120.0 0.6 5.4 5 1 0 5 5 5 1 Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_VWA PF11265.8 PIK43473.1 - 7.6e-58 195.8 0.0 1.3e-57 195.1 0.0 1.3 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A P2X_receptor PF00864.19 PIK43474.1 - 4.1e-65 220.3 0.4 4.6e-65 220.1 0.4 1.0 1 0 0 1 1 1 1 ATP P2X receptor P2X_receptor PF00864.19 PIK43475.1 - 7.3e-20 71.4 1.3 2.5e-19 69.6 0.2 1.9 2 0 0 2 2 2 1 ATP P2X receptor Pep3_Vps18 PF05131.14 PIK43476.1 - 9.7e-39 132.6 4.4 1.3e-36 125.7 1.6 3.1 2 1 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 PIK43476.1 - 3.1e-11 43.3 16.8 8.2e-11 42.0 4.3 3.9 4 1 0 4 4 4 2 Region in Clathrin and VPS Vps39_2 PF10367.9 PIK43476.1 - 5.1e-06 26.9 0.3 5.1e-06 26.9 0.3 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 PIK43476.1 - 0.0021 18.0 0.8 0.0066 16.4 0.8 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 PIK43476.1 - 0.0026 17.4 0.8 0.0077 16.0 0.8 1.9 1 0 0 1 1 1 1 RING-like zinc finger Ephrin_lbd PF01404.19 PIK43476.1 - 0.0063 16.6 0.2 0.016 15.3 0.2 1.6 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain zf-C3HC4_2 PF13923.6 PIK43476.1 - 0.0075 16.1 3.8 0.0079 16.0 1.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK43476.1 - 0.031 14.6 1.5 0.031 14.6 1.5 2.2 2 0 0 2 2 1 0 Ring finger domain DUF3788 PF12663.7 PIK43476.1 - 0.087 12.8 0.3 0.27 11.2 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) zf-RING_UBOX PF13445.6 PIK43476.1 - 0.089 12.8 1.3 0.28 11.3 1.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger DUF1664 PF07889.12 PIK43476.1 - 0.091 12.8 0.2 0.39 10.8 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Zn_ribbon_17 PF17120.5 PIK43476.1 - 0.2 11.3 4.5 0.073 12.7 1.1 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 PIK43476.1 - 0.23 11.5 2.4 0.62 10.1 2.4 1.7 1 0 0 1 1 1 0 Zinc-finger zf-rbx1 PF12678.7 PIK43476.1 - 0.29 11.5 1.0 1.1 9.6 1.0 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain FlaC_arch PF05377.11 PIK43476.1 - 1.8 9.0 3.9 2.2 8.8 0.1 3.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TRAM_LAG1_CLN8 PF03798.16 PIK43477.1 - 2.1e-05 24.3 9.2 0.0041 16.9 0.0 2.1 2 0 0 2 2 2 2 TLC domain SAICAR_synt PF01259.18 PIK43479.1 - 1.3e-17 64.3 0.0 1.7e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.20 PIK43480.1 - 8.6e-39 132.5 0.0 1.2e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 AIR carboxylase SAICAR_synt PF01259.18 PIK43480.1 - 9.6e-19 68.0 0.2 1.3e-18 67.5 0.2 1.1 1 0 0 1 1 1 1 SAICAR synthetase NOA36 PF06524.12 PIK43481.1 - 2.9e-149 496.5 45.1 3.4e-149 496.3 45.1 1.0 1 0 0 1 1 1 1 NOA36 protein DUF4598 PF15370.6 PIK43481.1 - 0.23 11.9 4.3 0.46 11.0 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) CDC45 PF02724.14 PIK43481.1 - 0.35 9.1 7.8 0.49 8.6 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 PIK43481.1 - 1.5 7.3 8.6 2.2 6.7 8.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM176 PF14851.6 PIK43481.1 - 2 8.1 8.0 6.4 6.4 6.1 2.3 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 PIK43481.1 - 2.9 7.2 12.5 5.3 6.3 12.5 1.4 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 PIK43481.1 - 7.6 4.5 18.4 13 3.7 18.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 PIK43481.1 - 8 4.5 14.9 11 4.0 14.9 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 PIK43481.1 - 8.2 6.3 11.7 1.1 9.1 7.5 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Mucin2_WxxW PF13330.6 PIK43482.1 - 2e-13 51.0 14.6 3.5e-12 47.0 0.6 4.0 3 2 0 3 3 3 2 Mucin-2 protein WxxW repeating region WSC PF01822.19 PIK43482.1 - 8.4e-10 38.7 3.0 8.4e-10 38.7 3.0 2.4 2 0 0 2 2 2 1 WSC domain Sushi PF00084.20 PIK43484.1 - 9.4e-38 128.6 19.1 4e-10 40.1 0.3 5.3 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) HRM PF02793.22 PIK43484.1 - 0.00074 19.8 19.8 0.046 14.0 0.2 4.7 4 1 1 5 5 5 3 Hormone receptor domain DUF2016 PF09436.10 PIK43484.1 - 0.19 11.5 0.0 15 5.5 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF2016) cEGF PF12662.7 PIK43484.1 - 0.86 9.6 13.7 1.2 9.2 0.3 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK43486.1 - 1.3e-18 67.3 37.0 1e-07 32.4 0.5 7.0 7 0 0 7 7 7 6 Sushi repeat (SCR repeat) p450 PF00067.22 PIK43488.1 - 4.2e-59 200.5 0.0 4.8e-59 200.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK43489.1 - 1.4e-80 271.3 0.0 1.5e-49 169.1 0.1 2.0 1 1 1 2 2 2 2 Cytochrome P450 ERCC4 PF02732.15 PIK43490.1 - 5.7e-22 78.6 0.0 1.4e-21 77.3 0.0 1.7 1 0 0 1 1 1 1 ERCC4 domain Vpu PF00558.19 PIK43490.1 - 5.9 6.7 5.4 26 4.7 5.4 2.1 1 0 0 1 1 1 0 Vpu protein SNF2_N PF00176.23 PIK43491.1 - 6.1e-72 242.2 1.2 1.3e-71 241.1 1.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Bromodomain PF00439.25 PIK43491.1 - 1.3e-22 79.7 0.5 5.6e-22 77.6 0.4 2.2 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.31 PIK43491.1 - 1.4e-20 73.6 0.0 5e-20 71.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 PIK43491.1 - 9.4e-16 58.2 6.7 9.4e-16 58.2 6.7 4.5 4 2 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 PIK43491.1 - 8e-09 35.7 1.4 2.9e-08 33.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SNAP-25 PF00835.19 PIK43491.1 - 0.016 15.5 0.0 0.049 13.9 0.0 1.9 1 0 0 1 1 1 0 SNAP-25 family BRK PF07533.16 PIK43492.1 - 3.6e-18 64.9 0.0 6.9e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 BRK domain HSA PF07529.13 PIK43492.1 - 7.9e-17 61.4 21.4 7.9e-17 61.4 21.4 2.5 2 0 0 2 2 2 1 HSA QLQ PF08880.11 PIK43492.1 - 3e-11 42.8 4.8 8.8e-11 41.4 4.1 2.3 2 0 0 2 2 2 1 QLQ NUP214 PF16755.5 PIK43492.1 - 5.8 6.1 8.7 0.49 9.6 0.5 2.1 1 1 1 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 DUF2009 PF09418.10 PIK43492.1 - 6.6 5.7 17.0 3 6.8 14.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2009) CPSase_L_D3 PF02787.19 PIK43492.1 - 8.3 6.8 10.9 0.74 10.2 2.8 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain SRCR PF00530.18 PIK43494.1 - 1e-28 99.8 13.1 3.6e-11 43.5 0.0 4.2 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Somatomedin_B PF01033.17 PIK43494.1 - 2.6e-07 30.9 18.4 1.9e-06 28.2 18.4 2.7 1 0 0 1 1 1 1 Somatomedin B domain ECF_trnsprt PF12822.7 PIK43494.1 - 7.1 6.7 7.1 2.2 8.4 2.9 2.1 1 1 0 2 2 2 0 ECF transporter, substrate-specific component Fanconi_C PF02106.15 PIK43495.1 - 2.2e-46 158.7 4.6 3.2e-46 158.2 4.6 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein RhoGAP PF00620.27 PIK43496.1 - 1.8e-41 141.5 0.0 3.2e-41 140.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PDZ PF00595.24 PIK43497.1 - 2.2e-10 40.7 0.2 5e-10 39.6 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK43497.1 - 5.8e-05 22.9 0.0 0.00016 21.5 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK43497.1 - 0.044 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 PDZ domain SAS-6_N PF16531.5 PIK43498.1 - 8e-15 55.2 1.0 8e-15 55.2 1.0 2.4 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal Sas6_CC PF18594.1 PIK43498.1 - 7.7e-07 28.8 0.7 7.7e-07 28.8 0.7 4.3 5 0 0 5 5 5 1 Sas6/XLF/XRCC4 coiled-coil domain AalphaY_MDB PF04611.12 PIK43498.1 - 0.028 14.5 0.4 0.028 14.5 0.4 2.7 2 1 1 3 3 3 0 Mating type protein A alpha Y mating type dependent binding region Spc7 PF08317.11 PIK43498.1 - 0.87 8.4 77.2 5.3 5.8 22.6 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein Pro_isomerase PF00160.21 PIK43499.1 - 1.5e-49 168.3 0.1 3.1e-49 167.3 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 PIK43499.1 - 5.4e-08 33.4 1.7 0.26 12.2 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat RBB1NT PF08169.11 PIK43499.1 - 0.021 15.0 0.4 3.9 7.7 0.1 2.7 2 0 0 2 2 2 0 RBB1NT (NUC162) domain ANAPC4_WD40 PF12894.7 PIK43499.1 - 0.14 12.5 0.0 2.1 8.7 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RNF220 PF15926.5 PIK43500.1 - 1.2e-46 159.3 10.9 1.2e-46 159.3 10.9 2.5 2 1 0 2 2 2 1 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 PIK43500.1 - 7.2e-14 51.4 8.5 7.2e-14 51.4 8.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK43500.1 - 7.6e-07 28.9 19.2 3.3e-06 26.8 7.6 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 PIK43500.1 - 2e-06 27.6 8.0 0.0009 19.1 1.4 2.9 3 0 0 3 3 3 2 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 PIK43500.1 - 3.4e-06 26.9 6.0 3.4e-06 26.9 6.0 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK43500.1 - 1.1e-05 25.6 8.3 1.1e-05 25.6 8.3 3.4 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 PIK43500.1 - 5.5e-05 23.0 6.8 5.5e-05 23.0 6.8 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK43500.1 - 0.00033 20.5 14.7 0.0012 18.7 5.6 3.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK43500.1 - 0.00034 20.6 5.7 0.00034 20.6 5.7 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-Nse PF11789.8 PIK43500.1 - 0.0011 18.7 1.3 0.0011 18.7 1.3 3.0 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 PIK43500.1 - 0.015 15.4 8.1 0.015 15.4 8.1 2.9 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-C2H2_9 PF16293.5 PIK43500.1 - 0.031 14.1 3.1 9.3 6.2 0.1 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Rad50_zn_hook PF04423.14 PIK43500.1 - 0.051 13.4 5.2 3.4 7.6 0.4 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif PRP21_like_P PF12230.8 PIK43500.1 - 0.09 12.6 2.8 0.74 9.6 0.3 2.3 1 1 1 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Spore_YhaL PF14147.6 PIK43500.1 - 0.28 10.9 2.0 0.31 10.7 0.0 2.1 3 0 0 3 3 2 0 Sporulation protein YhaL DNA_ligase_ZBD PF03119.16 PIK43500.1 - 1.1 9.4 10.0 3.4 7.8 0.2 3.8 5 0 0 5 5 5 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C2H2_3 PF13878.6 PIK43500.1 - 1.5 8.7 13.5 11 5.9 0.8 4.1 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO zf-RING_10 PF16685.5 PIK43500.1 - 3.5 7.8 11.8 0.4 10.9 6.9 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 ZU5 PF00791.20 PIK43501.1 - 3e-11 43.5 0.1 1.5e-10 41.3 0.0 2.3 2 0 0 2 2 2 1 ZU5 domain DED PF01335.21 PIK43501.1 - 0.0095 16.2 11.7 1.6 9.1 0.2 4.1 4 0 0 4 4 4 3 Death effector domain RVT_1 PF00078.27 PIK43502.1 - 1.2e-20 74.0 0.0 1.4e-20 73.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK43503.1 - 9.2e-26 90.8 0.0 2.2e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF5641 PF18701.1 PIK43503.1 - 8.7e-25 86.7 3.7 8.7e-25 86.7 3.7 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5641) rve PF00665.26 PIK43503.1 - 5.7e-09 36.2 0.0 1.4e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK43503.1 - 1.6e-08 34.5 0.1 6.7e-08 32.5 0.1 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK43503.1 - 4.2e-05 23.2 0.0 0.013 15.1 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) T3SSipB PF16535.5 PIK43504.1 - 0.035 14.6 33.2 0.12 12.8 2.2 4.2 1 1 2 4 4 4 0 Type III cell invasion protein SipB Lebercilin PF15619.6 PIK43504.1 - 0.038 13.7 71.7 0.36 10.5 27.5 3.4 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 PIK43504.1 - 0.53 10.3 41.4 0.21 11.6 0.8 6.4 1 1 6 7 7 7 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 PIK43504.1 - 0.72 10.3 58.1 2 8.8 13.8 3.6 1 1 2 3 3 3 0 Fez1 DUF4191 PF13829.6 PIK43504.1 - 1.5 8.1 6.3 2.4 7.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) DUF1192 PF06698.11 PIK43504.1 - 1.9 8.6 15.5 7 6.8 0.6 6.1 6 0 0 6 6 6 0 Protein of unknown function (DUF1192) Lectin_N PF03954.14 PIK43504.1 - 2.8 7.7 22.8 0.59 9.9 2.4 4.3 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain DUF948 PF06103.11 PIK43504.1 - 3.7 7.9 18.4 3.6 7.9 1.9 5.0 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.8 PIK43504.1 - 3.9 4.9 54.4 2.5 5.5 20.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Syntaxin-6_N PF09177.11 PIK43504.1 - 4.4 7.9 31.9 0.11 13.1 1.5 4.5 1 1 2 4 4 4 0 Syntaxin 6, N-terminal HrpB7 PF09486.10 PIK43504.1 - 7.9 6.8 43.3 11 6.3 4.8 4.7 1 1 4 5 5 5 0 Bacterial type III secretion protein (HrpB7) HMG_box PF00505.19 PIK43505.1 - 8.1e-28 96.6 3.0 1.1e-27 96.2 3.0 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK43505.1 - 5.3e-12 46.1 2.1 9.1e-12 45.4 2.1 1.4 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.8 PIK43505.1 - 0.00035 21.6 0.6 0.00035 21.6 0.6 1.8 2 0 0 2 2 2 1 SOX transcription factor Sushi PF00084.20 PIK43506.1 - 1.2e-21 77.1 10.1 1.9e-10 41.2 0.4 4.2 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK43506.1 - 1.8e-07 31.7 1.4 0.00015 22.3 0.1 3.5 3 2 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 PIK43506.1 - 4.5e-07 30.0 0.1 0.018 15.3 0.0 2.6 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK43506.1 - 5.4e-07 29.6 0.2 0.17 12.0 0.0 4.6 4 1 1 5 5 5 2 Immunoglobulin I-set domain ig PF00047.25 PIK43506.1 - 8.2e-06 25.9 1.7 0.072 13.3 0.5 4.0 4 1 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK43506.1 - 0.00097 19.3 1.0 1.5 9.0 0.0 3.3 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK43506.1 - 0.0013 19.0 0.2 0.017 15.4 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK43506.1 - 0.0033 17.8 0.4 0.046 14.1 0.0 2.6 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK43506.1 - 0.0082 15.7 0.3 0.35 10.5 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin domain Kunitz_BPTI PF00014.23 PIK43507.1 - 8e-18 64.4 2.3 8e-18 64.4 2.3 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain AMOP PF03782.17 PIK43508.1 - 1.3e-14 54.6 0.7 3.3e-14 53.2 0.7 1.7 1 1 0 1 1 1 1 AMOP domain Yip1 PF04893.17 PIK43508.1 - 0.059 13.1 0.5 0.079 12.7 0.5 1.2 1 0 0 1 1 1 0 Yip1 domain Arylesterase PF01731.20 PIK43509.1 - 4.1e-14 52.5 0.1 1.3e-13 51.0 0.1 1.9 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 PIK43509.1 - 0.0052 16.4 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 PIK43509.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Str_synth PF03088.16 PIK43509.1 - 0.023 14.8 0.1 1.1 9.5 0.1 2.8 3 0 0 3 3 3 0 Strictosidine synthase TPR_2 PF07719.17 PIK43510.1 - 1.4e-15 56.1 0.1 0.00061 19.7 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK43510.1 - 1.7e-14 52.9 0.2 3.9e-06 26.4 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43510.1 - 1e-10 41.7 0.9 0.00016 21.9 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43510.1 - 1.3e-07 31.1 0.1 0.07 12.8 0.0 4.3 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 PIK43510.1 - 2.1e-07 31.5 0.2 0.027 15.1 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43510.1 - 3.2e-06 27.6 0.1 0.075 13.6 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43510.1 - 2.7e-05 24.2 4.0 0.085 13.0 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43510.1 - 0.00019 21.4 0.0 0.42 10.9 0.0 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43510.1 - 0.00019 21.2 0.3 0.49 10.5 0.1 3.8 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43510.1 - 0.00024 21.3 0.1 1.5 9.4 0.0 4.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43510.1 - 0.00032 21.3 1.0 23 6.1 0.0 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43510.1 - 0.082 13.1 1.2 9.6 6.5 0.0 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 PIK43510.1 - 0.15 12.7 0.0 4.2 8.2 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43511.1 - 2e-15 55.6 0.1 0.0041 17.1 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43511.1 - 2.4e-14 52.7 0.7 8.5e-06 25.4 0.0 5.1 5 1 0 5 5 5 2 TPR repeat TPR_1 PF00515.28 PIK43511.1 - 1.9e-11 43.3 0.1 0.0052 16.5 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43511.1 - 1.1e-08 34.6 0.0 0.013 15.6 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43511.1 - 3.4e-07 30.3 3.1 0.044 13.9 1.5 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43511.1 - 8e-07 29.4 1.7 0.95 10.5 0.0 5.1 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43511.1 - 3.2e-06 27.1 0.2 0.14 12.6 0.0 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43511.1 - 0.00019 21.7 2.4 2 8.8 0.1 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43511.1 - 0.00029 21.4 0.1 1 10.1 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43511.1 - 0.13 13.0 0.6 25 5.8 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43511.1 - 0.49 10.6 3.4 1 9.7 0.4 2.6 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2201_N PF13203.6 PIK43511.1 - 8.6 5.9 13.7 0.53 9.8 6.6 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain IU_nuc_hydro PF01156.19 PIK43512.1 - 6.2e-22 78.5 0.0 6.5e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DNA_photolyase PF00875.18 PIK43513.1 - 2.7e-45 154.3 0.0 4e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.14 PIK43513.1 - 8.2e-34 116.8 1.5 1.3e-33 116.2 1.5 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase 7tm_1 PF00001.21 PIK43514.1 - 2.7e-39 135.1 19.5 3.6e-39 134.7 19.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43514.1 - 2.2e-10 40.4 18.6 2.9e-10 39.9 18.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK43514.1 - 3.2e-08 33.5 17.9 5.1e-08 32.9 17.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK43514.1 - 3e-05 23.7 14.8 6.1e-05 22.7 14.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 PIK43514.1 - 7.5e-05 22.6 14.2 0.00047 20.0 14.2 2.0 1 1 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 PIK43515.1 - 4.9e-39 134.2 18.5 6.2e-39 133.9 18.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK43515.1 - 2.6e-08 33.8 16.5 2.6e-08 33.8 16.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK43515.1 - 6e-06 25.8 17.2 1.1e-05 25.0 17.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 PIK43515.1 - 4.1e-05 23.2 12.7 4.1e-05 23.2 12.7 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 PIK43515.1 - 0.00083 19.2 15.6 0.011 15.5 15.6 2.1 1 1 0 1 1 1 1 Olfactory receptor Yip1 PF04893.17 PIK43515.1 - 0.13 12.0 12.5 0.0071 16.1 6.3 2.0 1 1 1 2 2 2 0 Yip1 domain DHHC PF01529.20 PIK43515.1 - 3.7 7.7 21.4 0.29 11.2 3.0 3.3 2 2 1 3 3 3 0 DHHC palmitoyltransferase PDEase_I PF00233.19 PIK43516.1 - 1.4e-82 277.0 2.1 1.4e-82 277.0 2.1 1.5 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 PIK43516.1 - 0.014 15.6 0.1 0.047 13.9 0.0 1.9 2 0 0 2 2 2 0 HD domain CAP PF00188.26 PIK43517.1 - 1.3e-21 77.8 5.4 1.6e-21 77.4 5.4 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Terminase_6 PF03237.15 PIK43517.1 - 0.0093 15.7 0.2 0.023 14.4 0.2 1.6 1 1 0 1 1 1 1 Terminase-like family FMN_bind PF04205.14 PIK43517.1 - 0.089 13.4 0.0 0.16 12.6 0.0 1.6 2 0 0 2 2 2 0 FMN-binding domain zf-C2H2 PF00096.26 PIK43518.1 - 2.1e-10 40.4 75.2 0.00047 20.5 1.9 10.2 11 0 0 11 11 11 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK43518.1 - 6.5e-09 35.8 56.8 0.0055 17.1 0.5 8.7 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK43518.1 - 1.2e-08 35.1 72.6 0.002 18.8 1.4 9.6 10 0 0 10 10 10 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK43518.1 - 3.4e-07 30.4 22.5 0.00032 20.9 1.9 5.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK43518.1 - 0.0013 19.1 1.4 0.0013 19.1 1.4 5.8 6 0 0 6 6 6 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 PIK43518.1 - 0.0048 17.5 52.7 0.95 10.1 0.4 8.6 5 2 3 8 8 8 4 FOXP coiled-coil domain zf-BED PF02892.15 PIK43518.1 - 0.021 14.8 6.2 0.021 14.8 6.2 5.8 2 2 3 5 5 5 0 BED zinc finger zf-Dof PF02701.15 PIK43518.1 - 0.029 14.5 0.3 0.029 14.5 0.3 3.3 3 1 0 3 3 3 0 Dof domain, zinc finger Zap1_zf2 PF18217.1 PIK43518.1 - 0.4 10.7 30.1 0.87 9.6 0.0 6.4 6 0 0 6 6 6 0 Zap1 zinc finger 2 zf_PR_Knuckle PF18445.1 PIK43519.1 - 0.022 14.6 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 PR zinc knuckle motif zf-C2H2_4 PF13894.6 PIK43520.1 - 1.8e-19 68.8 46.7 0.002 18.8 0.1 7.3 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK43520.1 - 1.5e-16 59.8 45.3 0.00035 20.9 0.1 7.4 7 1 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK43520.1 - 1.3e-09 38.0 43.8 1.2e-05 25.5 0.4 7.9 8 1 0 8 8 8 3 Zinc-finger double domain zf-MYST PF17772.1 PIK43520.1 - 8.4e-09 34.9 16.8 0.35 10.5 0.0 5.6 3 1 2 5 5 5 4 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 PIK43520.1 - 1.8e-05 24.9 24.5 0.021 15.1 0.1 6.4 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK43520.1 - 0.0012 19.1 33.8 0.068 13.5 1.3 5.1 3 1 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 PIK43520.1 - 0.0016 18.3 0.1 0.0053 16.6 0.1 1.9 1 0 0 1 1 1 1 Rad50 zinc hook motif zf-C2H2_2 PF12756.7 PIK43520.1 - 0.0024 18.1 35.5 1.7 9.0 3.4 6.2 1 1 5 6 6 6 2 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 PIK43520.1 - 0.006 16.2 12.2 3.8 7.2 0.1 5.0 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 PIK43520.1 - 0.023 15.4 25.3 0.66 10.8 0.7 3.8 2 2 1 3 3 3 0 zinc-ribbon family zf-C2HE PF16278.5 PIK43520.1 - 0.027 14.9 0.7 0.027 14.9 0.7 6.0 4 1 2 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 PIK43520.1 - 0.041 14.3 27.0 1 9.8 0.4 6.6 7 0 0 7 7 6 0 Zinc-finger of C2H2 type GAGA PF09237.11 PIK43520.1 - 0.047 13.5 3.6 48 3.9 0.1 4.4 3 1 1 4 4 4 0 GAGA factor zf-C2H2_8 PF15909.5 PIK43520.1 - 0.079 13.3 24.1 0.12 12.7 4.4 3.8 1 1 3 4 4 4 0 C2H2-type zinc ribbon zf-FPG_IleRS PF06827.14 PIK43520.1 - 0.13 12.1 10.2 0.27 11.2 2.4 3.7 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Elf1 PF05129.13 PIK43520.1 - 0.17 12.0 25.0 0.16 12.1 0.7 4.6 2 2 2 4 4 4 0 Transcription elongation factor Elf1 like zf_C2H2_13 PF18508.1 PIK43520.1 - 0.17 11.5 9.3 0.89 9.2 0.0 4.0 4 1 0 4 4 4 0 Zinc finger domain zf-C2H2_6 PF13912.6 PIK43520.1 - 0.26 11.3 0.3 0.26 11.3 0.3 6.0 6 0 0 6 6 5 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 PIK43520.1 - 0.66 10.5 0.1 0.66 10.5 0.1 5.5 6 0 0 6 6 6 0 Autophagy receptor zinc finger-C2H2 domain zf-C2HC_2 PF13913.6 PIK43520.1 - 3 7.9 37.7 0.96 9.4 0.1 7.0 8 1 0 8 8 6 0 zinc-finger of a C2HC-type HNH_5 PF14279.6 PIK43520.1 - 3.4 7.6 20.5 7.6 6.5 0.1 5.7 6 0 0 6 6 6 0 HNH endonuclease zf-trcl PF13451.6 PIK43520.1 - 8.3 6.4 16.6 10 6.1 0.2 4.8 5 0 0 5 5 5 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.10 PIK43520.1 - 8.8 6.5 19.8 16 5.7 3.9 5.0 4 1 0 4 4 4 0 Zinc ribbon domain zf-CCCH PF00642.24 PIK43521.1 - 6.1e-14 51.5 16.3 6.1e-07 29.2 2.6 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 PIK43521.1 - 1.9e-06 27.6 0.0 3.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 PIK43521.1 - 9.2e-06 26.3 5.2 0.028 15.1 0.2 2.6 3 0 0 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 PIK43521.1 - 4.2e-05 23.5 14.4 0.015 15.3 2.9 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_3 PF15663.5 PIK43521.1 - 0.01 16.0 4.5 0.55 10.5 0.1 2.4 2 1 0 2 2 2 0 Zinc-finger containing family Nup35_RRM_2 PF14605.6 PIK43521.1 - 0.029 14.3 0.4 0.071 13.1 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PRP38_assoc PF12871.7 PIK43521.1 - 0.32 11.6 22.4 0.67 10.6 22.4 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Transformer PF06495.11 PIK43521.1 - 6.6 6.8 15.4 11 6.0 15.4 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein PEN-2 PF10251.9 PIK43522.1 - 1.3e-38 131.3 3.9 1.4e-38 131.2 3.9 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase MpPF26 PF07666.11 PIK43522.1 - 0.0064 16.6 0.9 0.39 10.8 0.1 2.0 2 0 0 2 2 2 2 M penetrans paralogue family 26 Histone_H2A_C PF16211.5 PIK43523.1 - 2.8e-21 75.0 1.8 4.4e-21 74.3 1.8 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 PIK43523.1 - 6.7e-17 62.1 0.0 9.2e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK43523.1 - 5.4e-05 23.4 0.0 7.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Apc13p PF05839.11 PIK43524.1 - 3.8e-10 39.8 5.3 9.3e-09 35.4 5.3 2.0 1 1 0 1 1 1 1 Apc13p protein Peptidase_S8 PF00082.22 PIK43525.1 - 4.5e-41 141.1 1.3 7.2e-41 140.4 1.3 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 PIK43525.1 - 3.9e-28 97.3 0.1 1.2e-27 95.8 0.1 1.9 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 PIK43525.1 - 8e-12 45.8 0.3 1.8e-11 44.6 0.3 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 PIK43525.1 - 0.0034 17.9 0.2 0.0094 16.4 0.2 1.7 1 0 0 1 1 1 1 N-terminal of Subtilase family E1_DerP2_DerF2 PF02221.15 PIK43528.1 - 0.014 15.9 0.0 0.26 11.7 0.0 2.2 1 1 0 1 1 1 0 ML domain Lectin_C PF00059.21 PIK43529.1 - 2e-18 67.1 5.3 1.8e-12 47.9 0.1 2.8 2 1 0 2 2 2 2 Lectin C-type domain Viral_cys_rich PF08008.12 PIK43529.1 - 0.046 13.8 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 Viral cysteine rich zf-4CXXC_R1 PF10497.9 PIK43530.1 - 7.6e-39 131.9 9.7 1.3e-38 131.2 9.7 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Fibrinogen_C PF00147.18 PIK43531.1 - 3.9e-59 200.1 8.0 4.7e-59 199.8 8.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK43531.1 - 0.2 11.5 2.7 0.37 10.7 2.7 1.4 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) VCBS PF13517.6 PIK43531.1 - 2.3 8.9 8.0 5.9 7.6 0.8 2.8 1 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-CCHC PF00098.23 PIK43532.1 - 1e-07 31.7 1.9 2.3e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43532.1 - 0.00036 20.3 0.1 0.00036 20.3 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK43532.1 - 0.13 12.0 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK43532.1 - 0.19 11.8 0.3 0.45 10.6 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK43532.1 - 0.24 11.2 0.5 0.5 10.1 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK43533.1 - 3e-37 126.6 0.1 6.6e-37 125.6 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK43533.1 - 1.3e-33 115.4 0.1 3.5e-33 114.0 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK43533.1 - 5.4e-31 107.8 0.0 9.1e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK43533.1 - 2.5e-23 82.5 0.1 8.7e-23 80.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK43533.1 - 1.2e-17 63.8 1.0 1.2e-17 63.8 1.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK43533.1 - 0.0037 17.4 0.6 0.0037 17.4 0.6 3.3 4 0 0 4 4 4 1 H2C2 zinc finger rve_3 PF13683.6 PIK43533.1 - 0.016 15.0 0.0 0.042 13.6 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MycE_N PF17843.1 PIK43533.1 - 0.063 13.8 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 MycE methyltransferase N-terminal 7tm_1 PF00001.21 PIK43534.1 - 2.9e-15 56.3 1.1 3.6e-15 56.0 1.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK43534.1 - 3.9e-05 23.1 0.5 4.8e-05 22.8 0.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF2304 PF10066.9 PIK43534.1 - 0.1 12.9 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Peptidase_A17 PF05380.13 PIK43537.1 - 3.6e-12 46.6 0.0 7.1e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase HTH_Tnp_Tc5 PF03221.16 PIK43537.1 - 0.022 14.8 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Sec1 PF00995.23 PIK43538.1 - 9e-17 61.5 0.0 9e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.23 PIK43539.1 - 6.1e-62 210.6 0.2 6.9e-62 210.5 0.2 1.0 1 0 0 1 1 1 1 Sec1 family Urm1 PF09138.11 PIK43540.1 - 1.5e-39 134.3 0.2 1.7e-39 134.1 0.2 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 PIK43540.1 - 0.00035 21.1 0.0 0.00045 20.8 0.0 1.2 1 0 0 1 1 1 1 ThiS family FMO-like PF00743.19 PIK43541.1 - 4.6e-102 342.2 0.4 5.5e-82 275.9 0.1 2.8 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK43541.1 - 7e-11 41.9 0.2 3e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK43541.1 - 2e-06 27.3 0.0 0.012 14.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK43541.1 - 6.4e-06 25.5 0.8 0.00024 20.4 0.1 2.4 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DUF2914 PF11141.8 PIK43541.1 - 0.12 12.2 0.2 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) Tnp_P_element PF12017.8 PIK43542.1 - 0.0057 16.1 0.0 0.041 13.3 0.0 2.1 2 0 0 2 2 2 1 Transposase protein FMO-like PF00743.19 PIK43543.1 - 5.3e-35 120.8 0.0 1.7e-31 109.3 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK43543.1 - 0.073 12.3 0.4 3.5 6.8 0.0 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cullin PF00888.22 PIK43544.1 - 8.2e-26 90.8 3.0 1.8e-25 89.7 3.0 1.5 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 PIK43544.1 - 3.3e-24 85.2 1.7 1.4e-23 83.2 0.2 2.8 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 HTH_DeoR PF08220.12 PIK43544.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DUF1912 PF08930.10 PIK43544.1 - 0.11 12.7 0.4 0.44 10.7 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1912) Ribosomal_L28 PF00830.19 PIK43544.1 - 0.13 12.5 0.0 0.4 10.9 0.0 1.8 1 1 1 2 2 2 0 Ribosomal L28 family BSP_II PF05432.11 PIK43544.1 - 4 7.1 14.4 0.064 13.0 1.7 2.9 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) Kinetochor_Ybp2 PF08568.10 PIK43545.1 - 1.6e-24 86.4 0.1 1.8e-24 86.2 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin HSP70 PF00012.20 PIK43546.1 - 1.2e-122 410.1 8.1 4.2e-119 398.4 1.1 2.3 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK43546.1 - 6.2e-11 41.7 0.2 2.6e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Spore_YhaL PF14147.6 PIK43546.1 - 0.45 10.2 2.2 0.47 10.2 0.0 2.2 2 0 0 2 2 2 0 Sporulation protein YhaL DUF1542 PF07564.11 PIK43546.1 - 0.79 9.9 5.7 1.9 8.7 5.7 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) MMtag PF10159.9 PIK43546.1 - 3.4 8.0 0.0 3.4 8.0 0.0 3.4 3 1 1 4 4 4 0 Multiple myeloma tumor-associated SH2 PF00017.24 PIK43547.1 - 6.9e-16 58.1 0.1 1.8e-15 56.8 0.1 1.7 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 PIK43547.1 - 1.6e-14 53.5 0.0 2.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK43547.1 - 1.8e-13 49.8 0.0 3.3e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK43547.1 - 2.1e-11 43.3 0.0 5.1e-11 42.1 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain C1_1 PF00130.22 PIK43547.1 - 9.7e-09 35.0 6.9 1.6e-08 34.3 6.9 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Rho_RNA_bind PF07497.12 PIK43547.1 - 0.0003 20.6 0.0 0.00064 19.6 0.0 1.6 1 0 0 1 1 1 1 Rho termination factor, RNA-binding domain C1_2 PF03107.16 PIK43547.1 - 0.0013 19.0 4.9 0.0028 17.9 4.9 1.5 1 0 0 1 1 1 1 C1 domain PH PF00169.29 PIK43547.1 - 0.0022 18.5 0.0 0.0052 17.3 0.0 1.7 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 PIK43547.1 - 0.0041 17.3 2.3 0.0065 16.7 2.3 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger zf-RING-like PF08746.11 PIK43547.1 - 0.038 14.3 5.2 0.069 13.5 5.2 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 PIK43547.1 - 0.095 12.6 4.6 0.18 11.7 4.6 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.6 PIK43547.1 - 0.12 12.4 7.3 0.23 11.4 6.7 1.8 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon Prok-RING_1 PF14446.6 PIK43547.1 - 0.45 10.5 4.3 0.85 9.6 4.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 PIK43547.1 - 4.8 6.8 8.7 0.17 11.5 2.5 1.8 2 0 0 2 2 2 0 PHD-finger RhoGEF PF00621.20 PIK43548.1 - 1.8e-40 139.2 5.3 3.2e-40 138.3 5.3 1.4 1 0 0 1 1 1 1 RhoGEF domain P22_CoatProtein PF11651.8 PIK43548.1 - 0.11 11.1 0.0 0.21 10.1 0.0 1.4 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 CR6_interact PF10147.9 PIK43549.1 - 5.5e-29 101.4 15.5 6.8e-29 101.0 15.5 1.1 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 SET PF00856.28 PIK43549.1 - 0.023 15.1 0.4 0.026 14.9 0.4 1.2 1 0 0 1 1 1 0 SET domain AbiH PF14253.6 PIK43549.1 - 0.24 11.2 1.4 0.32 10.8 1.4 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Death PF00531.22 PIK43550.1 - 1.5e-12 47.5 0.6 2.5e-12 46.8 0.6 1.4 1 0 0 1 1 1 1 Death domain PolC_DP2 PF03833.13 PIK43550.1 - 0.079 10.8 0.1 0.096 10.5 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Ank PF00023.30 PIK43551.1 - 2.7e-25 87.6 1.6 5.7e-08 32.9 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 PIK43551.1 - 7.3e-25 87.4 1.2 1.1e-17 64.3 0.1 2.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK43551.1 - 1.4e-22 79.4 2.9 5.7e-10 39.3 0.1 3.8 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK43551.1 - 2.6e-21 75.7 2.3 3.7e-12 46.5 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK43551.1 - 3e-21 73.2 0.5 1.1e-05 25.4 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat DUF3498 PF12004.8 PIK43551.1 - 0.083 12.1 4.7 0.11 11.7 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) NAM-associated PF14303.6 PIK43551.1 - 0.13 13.0 4.7 0.3 11.8 4.7 1.6 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain SR-25 PF10500.9 PIK43551.1 - 0.37 10.4 10.7 0.61 9.7 10.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein KN_motif PF12075.8 PIK43552.1 - 9.4e-08 31.7 0.0 3.2e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 KN motif DUF3552 PF12072.8 PIK43552.1 - 0.0057 16.1 23.2 0.0057 16.1 23.2 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) COG4 PF08318.12 PIK43555.1 - 1.2e-69 235.0 1.5 2.1e-69 234.2 1.5 1.4 1 0 0 1 1 1 1 COG4 transport protein Sec10 PF07393.11 PIK43555.1 - 7.1e-06 24.7 2.1 7.8e-06 24.6 0.5 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec10 DIL PF01843.19 PIK43555.1 - 0.00099 19.3 0.2 3.2 8.1 0.0 2.9 2 0 0 2 2 2 2 DIL domain NapD PF03927.13 PIK43557.1 - 0.11 12.6 1.0 0.19 11.8 1.0 1.4 1 0 0 1 1 1 0 NapD protein zf-C2H2 PF00096.26 PIK43558.1 - 5.4e-23 80.1 28.4 8.1e-06 26.0 1.1 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK43558.1 - 3.9e-15 55.3 23.4 0.00034 21.2 0.6 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK43558.1 - 0.0018 18.6 37.4 0.3 11.6 2.9 7.5 8 0 0 8 8 8 3 Zinc-finger double domain zf-met PF12874.7 PIK43558.1 - 0.0025 18.1 9.1 0.6 10.6 0.3 4.6 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK43558.1 - 0.0076 16.6 11.7 6.8 7.1 2.6 4.8 3 2 1 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 PIK43558.1 - 0.0087 16.3 0.2 0.018 15.3 0.2 5.1 6 0 0 6 6 5 2 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 PIK43558.1 - 0.057 13.1 0.5 3.1 7.5 0.0 3.4 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_8 PF15909.5 PIK43558.1 - 0.1 12.9 9.4 2.8 8.3 0.4 3.5 2 1 1 3 3 3 0 C2H2-type zinc ribbon Actin_micro PF17003.5 PIK43558.1 - 2.3 7.3 4.6 5.5 6.1 0.6 2.5 2 1 0 2 2 2 0 Putative actin-like family C1_4 PF07975.12 PIK43558.1 - 4.9 7.5 8.1 15 5.9 0.8 2.9 2 0 0 2 2 2 0 TFIIH C1-like domain zf-C2H2_6 PF13912.6 PIK43558.1 - 6.7 6.8 22.0 0.11 12.5 0.3 4.0 5 0 0 5 5 5 0 C2H2-type zinc finger RRM_1 PF00076.22 PIK43559.1 - 7.6e-12 44.9 0.0 1.2e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK43559.1 - 0.15 12.0 0.1 0.27 11.3 0.1 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Rsm22 PF09243.10 PIK43560.1 - 8e-58 195.9 0.0 1.3e-57 195.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 PIK43560.1 - 2.2e-05 24.4 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK43560.1 - 0.0044 17.7 0.0 0.014 16.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF1319 PF07028.11 PIK43560.1 - 0.099 12.9 0.3 0.37 11.0 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Methyltransf_12 PF08242.12 PIK43560.1 - 0.15 12.8 0.0 0.56 11.0 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 PIK43561.1 - 2.5e-12 46.4 0.0 5.9e-12 45.2 0.0 1.7 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK43561.1 - 8.6e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK43562.1 - 1.6e-13 50.3 0.1 2.7e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK43562.1 - 0.00015 21.3 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNAP PF14938.6 PIK43563.1 - 1.3e-07 31.4 8.2 3e-06 26.9 1.7 3.0 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 PIK43563.1 - 0.027 14.8 0.4 0.027 14.8 0.4 2.8 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43563.1 - 0.043 14.5 7.3 1.3 9.7 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.9 PIK43563.1 - 0.17 11.6 7.0 0.39 10.4 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain DUF4810 PF16068.5 PIK43563.1 - 0.23 12.0 2.8 1.1 9.9 1.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4810) TPR_8 PF13181.6 PIK43563.1 - 8.6 6.9 8.4 1.3 9.4 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43563.1 - 9.7 6.6 13.1 2.1 8.7 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DLIC PF05783.11 PIK43564.1 - 8.9e-171 568.8 3.5 7e-170 565.9 3.7 2.0 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 PIK43564.1 - 0.00096 18.4 0.0 0.0028 16.9 0.0 1.7 1 1 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 PIK43564.1 - 0.00097 19.4 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43564.1 - 0.0091 15.5 0.0 0.028 13.9 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family PduV-EutP PF10662.9 PIK43564.1 - 0.0098 15.6 0.1 0.23 11.2 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 PIK43564.1 - 0.017 15.7 0.4 0.08 13.5 0.0 2.2 3 0 0 3 3 3 0 ABC transporter AAA_16 PF13191.6 PIK43564.1 - 0.078 13.3 0.0 0.29 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 PIK43565.1 - 8.3e-53 178.3 0.0 1.1e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK43565.1 - 8.8e-30 103.4 0.0 1.5e-29 102.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43565.1 - 1.2e-12 47.7 0.0 1.9e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK43565.1 - 0.00097 19.1 0.0 0.78 9.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 PIK43565.1 - 0.0016 17.8 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK43565.1 - 0.0094 16.0 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK43565.1 - 0.02 14.5 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Na_H_Exchanger PF00999.21 PIK43566.1 - 2.9e-81 273.2 43.7 3.7e-81 272.9 43.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 PIK43567.1 - 0.012 15.9 0.1 0.022 15.0 0.1 1.4 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin UQ_con PF00179.26 PIK43568.1 - 8.1e-23 80.6 0.0 1.2e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Dus PF01207.17 PIK43569.1 - 4.3e-51 173.9 0.7 2.1e-50 171.6 0.7 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) dsrm PF00035.26 PIK43569.1 - 8.6e-10 39.2 0.0 1.8e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif His_biosynth PF00977.21 PIK43569.1 - 0.0054 16.2 0.0 0.0088 15.5 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein DND1_DSRM PF14709.7 PIK43569.1 - 0.0099 16.1 0.3 0.069 13.4 0.3 2.3 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 ORC6 PF05460.13 PIK43571.1 - 4.2e-09 36.1 0.8 4.3e-06 26.2 0.0 2.6 2 1 1 3 3 3 2 Origin recognition complex subunit 6 (ORC6) FeoC PF09012.10 PIK43571.1 - 0.074 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator Laminin_G_3 PF13385.6 PIK43572.1 - 6.7e-56 188.7 34.1 3.1e-10 40.4 0.1 8.2 8 1 0 8 8 8 6 Concanavalin A-like lectin/glucanases superfamily 7tm_2 PF00002.24 PIK43572.1 - 3.5e-38 131.3 17.8 5.5e-38 130.6 17.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 PIK43572.1 - 8.2e-16 58.1 2.2 8.2e-16 58.1 2.2 1.6 2 0 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 PIK43572.1 - 3.1e-11 43.6 4.8 3.1e-11 43.6 4.8 3.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF_CA PF07645.15 PIK43572.1 - 1.2e-08 35.0 5.2 1.2e-08 35.0 5.2 4.0 2 1 1 3 3 3 2 Calcium-binding EGF domain Toxin_R_bind_N PF07953.12 PIK43572.1 - 1.7e-07 31.2 11.7 0.0024 17.6 0.0 6.1 6 0 0 6 6 6 2 Clostridium neurotoxin, N-terminal receptor binding EGF PF00008.27 PIK43572.1 - 0.0004 20.6 45.5 0.00044 20.5 8.6 4.9 5 0 0 5 5 5 3 EGF-like domain FXa_inhibition PF14670.6 PIK43572.1 - 6.9 7.0 33.3 2.7 8.4 7.9 4.0 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site AA_permease_2 PF13520.6 PIK43573.1 - 1.8e-54 185.2 45.6 2.2e-54 184.9 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK43573.1 - 4.4e-28 98.1 40.0 7.3e-28 97.4 40.0 1.3 1 1 0 1 1 1 1 Amino acid permease SirB PF04247.12 PIK43573.1 - 1 9.5 9.5 0.072 13.2 0.8 3.1 3 0 0 3 3 3 0 Invasion gene expression up-regulator, SirB DUF563 PF04577.14 PIK43574.1 - 4.8e-20 72.6 0.1 7.7e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) adh_short_C2 PF13561.6 PIK43575.1 - 5.9e-44 150.4 0.0 7.9e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK43575.1 - 4.2e-36 124.2 0.1 6.5e-36 123.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK43575.1 - 1.7e-09 37.8 0.1 3.2e-09 37.0 0.0 1.4 2 0 0 2 2 2 1 KR domain F420_oxidored PF03807.17 PIK43575.1 - 0.013 16.1 0.4 0.029 14.9 0.4 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 PIK43575.1 - 0.025 14.4 0.3 0.046 13.6 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 PIK43575.1 - 0.035 13.3 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sas10_Utp3 PF04000.15 PIK43576.1 - 1.1e-16 61.2 3.0 1.9e-16 60.4 0.5 2.5 2 0 0 2 2 2 1 Sas10/Utp3/C1D family FATC PF02260.20 PIK43576.1 - 0.026 14.3 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 0 FATC domain Spidroin_MaSp PF11260.8 PIK43576.1 - 0.18 12.1 0.7 0.33 11.3 0.7 1.4 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 Retrotrans_gag PF03732.17 PIK43577.1 - 3.6e-07 30.4 0.8 4.9e-07 29.9 0.1 1.5 2 0 0 2 2 2 1 Retrotransposon gag protein RT_RNaseH_2 PF17919.1 PIK43578.1 - 5.4e-34 116.2 0.0 8.4e-34 115.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK43578.1 - 2.6e-27 95.8 0.1 5e-27 94.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK43578.1 - 4.1e-23 81.7 0.0 6.7e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pkinase PF00069.25 PIK43579.1 - 7.2e-34 117.3 0.4 6.9e-22 78.1 0.3 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43579.1 - 1.9e-29 102.7 0.4 2.3e-19 69.7 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase ACOX PF01756.19 PIK43579.1 - 0.003 17.2 0.0 0.0055 16.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Kdo PF06293.14 PIK43579.1 - 0.0034 16.8 0.2 0.0057 16.0 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK43579.1 - 0.18 11.4 0.1 0.18 11.4 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 PIK43579.1 - 0.3 9.8 0.0 0.3 9.8 0.0 3.0 2 1 0 2 2 2 0 Fungal protein kinase SWI-SNF_Ssr4 PF08549.10 PIK43579.1 - 2.3 6.7 19.5 3.3 6.2 19.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CARD PF00619.21 PIK43580.1 - 1.6e-14 53.7 1.0 3e-14 52.8 0.3 1.9 3 0 0 3 3 3 1 Caspase recruitment domain Death PF00531.22 PIK43580.1 - 3.4e-11 43.2 0.9 1.8e-10 40.8 0.0 2.3 2 1 0 2 2 2 1 Death domain CARD_2 PF16739.5 PIK43580.1 - 1.4e-05 25.0 0.3 3.1e-05 23.9 0.3 1.6 1 0 0 1 1 1 1 Caspase recruitment domain CEP19 PF14933.6 PIK43580.1 - 0.056 13.8 0.4 0.11 12.8 0.4 1.5 1 1 0 1 1 1 0 CEP19-like protein RRM_1 PF00076.22 PIK43582.1 - 2.1e-11 43.5 0.0 3e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 PIK43582.1 - 2.8e-06 27.2 1.3 2.8e-06 27.2 1.3 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK43582.1 - 0.0088 16.0 2.1 0.018 15.0 2.1 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK43582.1 - 0.06 13.1 3.8 0.13 12.0 3.8 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 PIK43582.1 - 0.16 11.7 1.2 0.28 11.0 0.4 1.8 2 0 0 2 2 2 0 Zinc knuckle RRM_1 PF00076.22 PIK43583.1 - 2.2e-14 53.0 0.0 3e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK43583.1 - 0.0012 18.5 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RHINO PF15319.6 PIK43584.1 - 1.1e-15 58.4 5.3 1.8e-15 57.7 5.3 1.3 1 1 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein Forkhead PF00250.18 PIK43585.1 - 8.7e-29 99.6 0.0 1.6e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain CBFB_NFYA PF02045.15 PIK43586.1 - 8.6e-28 96.7 7.9 1.7e-27 95.8 7.9 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DHQS PF01959.16 PIK43586.1 - 0.028 13.3 0.4 0.042 12.8 0.4 1.2 1 0 0 1 1 1 0 3-dehydroquinate synthase II DUF4520 PF15016.6 PIK43586.1 - 0.29 11.2 5.7 0.74 9.9 0.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4520) RCC1 PF00415.18 PIK43587.1 - 3.6e-60 200.4 15.9 9.2e-12 45.4 0.1 6.1 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK43587.1 - 3.8e-41 138.1 34.2 7e-10 38.4 2.1 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Na_H_Exchanger PF00999.21 PIK43588.1 - 6.2e-59 199.7 41.9 9.4e-59 199.1 41.9 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Ion_trans PF00520.31 PIK43588.1 - 7.1e-13 48.3 8.0 7.1e-13 48.3 8.0 2.8 2 1 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.29 PIK43588.1 - 8e-13 48.3 0.0 2.1e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain IQ PF00612.27 PIK43589.1 - 6.8e-54 174.6 187.5 1.4e-05 24.5 0.2 27.2 27 0 0 27 27 27 23 IQ calmodulin-binding motif NtA PF03146.15 PIK43589.1 - 0.68 9.8 14.7 1.3 8.9 0.3 4.4 5 0 0 5 5 5 0 Agrin NtA domain IQ PF00612.27 PIK43590.1 - 2.9e-90 287.7 254.3 0.00018 21.0 2.4 36.9 37 0 0 37 37 37 35 IQ calmodulin-binding motif QslA_E PF18226.1 PIK43590.1 - 0.23 11.4 4.7 19 5.3 0.1 4.2 3 0 0 3 3 3 0 LasR-specific antiactivator QslA chain E CH PF00307.31 PIK43592.1 - 5.3e-07 29.8 0.1 3.9e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain Ferritin PF00210.24 PIK43594.1 - 1.8e-40 138.2 3.0 2.1e-40 137.9 3.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 PIK43594.1 - 0.012 16.0 1.9 0.017 15.5 1.9 1.5 1 1 0 1 1 1 0 Rubrerythrin FCH PF00611.23 PIK43594.1 - 0.018 15.3 0.7 0.031 14.5 0.7 1.4 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Cu-oxidase_2 PF07731.14 PIK43595.1 - 1e-29 103.0 0.0 1.8e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK43596.1 - 2.7e-39 133.9 2.7 3.6e-39 133.5 0.5 2.2 2 1 1 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 PIK43596.1 - 7.7e-28 97.6 0.2 6.6e-27 94.6 0.0 2.2 2 1 0 2 2 2 1 Multicopper oxidase CPSF_A PF03178.15 PIK43597.1 - 8.7e-70 235.6 0.0 2.1e-69 234.3 0.0 1.6 2 0 0 2 2 2 1 CPSF A subunit region Ephrin_rec_like PF07699.13 PIK43599.1 - 0.0015 18.3 1.1 0.0015 18.3 1.1 5.0 4 1 0 4 4 4 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK43599.1 - 6 6.9 24.6 1 9.4 0.5 4.0 4 0 0 4 4 4 0 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 PIK43600.1 - 1.3e-06 28.0 2.4 1.3e-06 28.0 2.4 3.8 1 1 2 3 3 3 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK43600.1 - 0.059 13.3 6.0 1.9 8.5 1.0 2.9 1 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR DUF764 PF05561.11 PIK43600.1 - 0.09 12.6 0.7 0.19 11.5 0.7 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) Pacifastin_I PF05375.13 PIK43603.1 - 0.24 11.2 8.4 0.88 9.3 6.3 2.1 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) RVT_1 PF00078.27 PIK43604.1 - 0.0056 16.2 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) XRCC4 PF06632.12 PIK43605.1 - 2e-08 33.5 0.3 2.1e-08 33.4 0.3 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 PAXX PF15384.6 PIK43605.1 - 0.057 13.1 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Myb_DNA-bind_4 PF13837.6 PIK43606.1 - 0.00043 20.6 1.2 0.00043 20.6 1.2 2.4 2 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain UPF0242 PF06785.11 PIK43606.1 - 0.58 10.2 27.0 0.032 14.3 14.7 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_C_Rb_bdg PF10490.9 PIK43608.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Rb-binding domain of kinetochore protein Cenp-F/LEK1 LIM_bind PF01803.16 PIK43608.1 - 0.18 11.3 3.5 0.25 10.9 3.5 1.2 1 0 0 1 1 1 0 LIM-domain binding protein MREG PF15812.5 PIK43609.1 - 4.4e-37 127.7 0.5 5.5e-37 127.4 0.5 1.1 1 0 0 1 1 1 1 Melanoregulin AAA_16 PF13191.6 PIK43609.1 - 0.00019 21.9 0.0 0.00026 21.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain CortBP2 PF09727.9 PIK43609.1 - 0.017 15.1 0.5 0.023 14.6 0.5 1.2 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF4362 PF14275.6 PIK43609.1 - 0.057 13.7 0.3 0.081 13.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) CUB PF00431.20 PIK43610.1 - 6.2e-08 33.0 0.2 9.2e-08 32.4 0.2 1.3 1 0 0 1 1 1 1 CUB domain CW_binding_1 PF01473.20 PIK43610.1 - 0.036 14.4 0.2 0.11 12.9 0.2 1.8 1 0 0 1 1 1 0 Putative cell wall binding repeat EGF PF00008.27 PIK43610.1 - 0.55 10.6 5.7 2.1 8.8 5.7 2.0 1 0 0 1 1 1 0 EGF-like domain CX PF01705.19 PIK43610.1 - 2 9.0 6.3 0.61 10.7 0.7 2.7 3 0 0 3 3 3 0 CX module HYR PF02494.16 PIK43611.1 - 1.4e-13 50.9 0.2 2.5e-13 50.2 0.2 1.4 1 0 0 1 1 1 1 HYR domain P_C PF06640.11 PIK43611.1 - 0.9 9.6 5.0 1.3 9.1 5.0 1.1 1 0 0 1 1 1 0 P protein C-terminus Nucleotid_trans PF03407.16 PIK43612.1 - 4.6e-36 124.8 0.5 6.4e-36 124.3 0.5 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Na_Pi_cotrans PF02690.15 PIK43613.1 - 6.5e-12 45.7 16.5 8.9e-12 45.3 14.8 2.2 1 1 1 2 2 2 1 Na+/Pi-cotransporter DUF2207 PF09972.9 PIK43613.1 - 0.012 14.4 10.6 0.017 13.9 1.8 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) WAP PF00095.21 PIK43614.1 - 2.1e-05 24.8 10.1 3.4e-05 24.1 10.1 1.3 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' fn3 PF00041.21 PIK43615.1 - 4.5e-83 273.7 16.7 1.5e-17 63.7 0.1 9.9 10 0 0 10 10 10 8 Fibronectin type III domain DUF2369 PF10179.9 PIK43615.1 - 1.3e-12 47.9 0.0 2.4 8.6 0.0 7.3 7 0 0 7 7 7 3 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 PIK43615.1 - 2.3e-12 47.3 20.4 0.17 12.4 0.2 10.1 7 4 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK43615.1 - 5.5e-09 36.3 0.0 0.18 12.2 0.0 6.7 6 1 0 6 6 6 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 PIK43615.1 - 0.0017 18.5 6.5 0.091 12.9 0.0 5.0 6 0 0 6 6 6 1 Fibronectin type III domain DUF1410 PF07198.11 PIK43615.1 - 0.0053 17.2 1.3 28 5.3 0.0 4.9 6 0 0 6 6 6 2 Protein of unknown function (DUF1410) SRP19 PF01922.17 PIK43616.1 - 3.3e-29 101.7 0.1 4.1e-29 101.4 0.1 1.1 1 0 0 1 1 1 1 SRP19 protein Cdc6_C PF09079.11 PIK43616.1 - 0.047 13.7 0.0 0.093 12.7 0.0 1.5 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain COesterase PF00135.28 PIK43617.1 - 4.2e-139 464.7 0.0 4.7e-139 464.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK43617.1 - 8.8e-09 35.5 0.6 3e-08 33.8 0.6 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK43617.1 - 0.0006 19.5 3.7 0.0012 18.5 3.7 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Ig_3 PF13927.6 PIK43618.1 - 1.3e-43 147.5 0.4 2.1e-13 50.6 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 PIK43618.1 - 3e-41 139.4 0.0 1.2e-13 50.9 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK43618.1 - 3.3e-32 110.6 0.3 6.2e-09 36.1 0.0 4.2 3 1 1 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK43618.1 - 2.3e-26 91.8 0.0 1.4e-06 28.4 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK43618.1 - 2.9e-16 59.6 7.9 0.0011 19.1 0.1 7.4 4 4 2 6 6 6 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK43618.1 - 4.2e-08 32.6 1.0 0.16 11.6 0.0 4.3 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK43618.1 - 1.3e-07 31.6 0.2 0.0013 18.7 0.0 3.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK43618.1 - 4.6e-07 30.2 0.3 0.021 15.2 0.0 4.2 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK43618.1 - 6.6e-05 23.1 0.3 0.0057 16.9 0.0 3.5 4 1 0 4 4 3 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK43618.1 - 0.00039 20.4 0.0 20 5.4 0.0 4.3 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK43618.1 - 0.0043 16.8 0.9 23 4.9 0.0 4.5 4 1 0 4 4 4 0 Adenovirus E3 region protein CR1 Kelch_4 PF13418.6 PIK43618.1 - 0.25 11.4 1.3 0.51 10.4 0.0 2.2 3 0 0 3 3 3 0 Galactose oxidase, central domain fn3 PF00041.21 PIK43619.1 - 2e-40 137.0 8.0 1e-11 45.0 0.2 5.3 5 0 0 5 5 5 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK43619.1 - 1.7e-10 41.3 8.0 0.039 14.5 0.1 4.7 4 1 0 4 4 4 4 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 PIK43619.1 - 0.038 13.8 5.8 1.3 8.9 0.2 3.6 2 1 0 3 3 3 0 Tissue factor zf-A20 PF01754.16 PIK43623.1 - 5.1e-12 45.5 9.3 5.1e-12 45.5 9.3 2.4 2 0 0 2 2 2 1 A20-like zinc finger zf-AN1 PF01428.16 PIK43623.1 - 2.6e-09 37.1 9.9 2.6e-09 37.1 9.9 2.3 2 0 0 2 2 2 1 AN1-like Zinc finger Zn-C2H2_12 PF18112.1 PIK43624.1 - 0.0021 18.5 2.0 0.0055 17.1 2.0 1.7 1 0 0 1 1 1 1 Autophagy receptor zinc finger-C2H2 domain DUF3039 PF11238.8 PIK43624.1 - 0.071 12.9 0.6 0.2 11.4 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) HSP70 PF00012.20 PIK43625.1 - 2.2e-143 478.6 0.4 2.7e-143 478.3 0.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK43625.1 - 1.1e-12 47.5 0.2 3.6e-11 42.4 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 PIK43625.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 StbA protein Hydantoinase_A PF01968.18 PIK43625.1 - 0.013 14.7 0.5 0.047 12.9 0.1 2.1 1 1 2 3 3 3 0 Hydantoinase/oxoprolinase Ppx-GppA PF02541.16 PIK43625.1 - 0.058 12.8 0.1 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 Ppx/GppA phosphatase family DUF1631 PF07793.11 PIK43625.1 - 0.2 10.0 1.2 0.29 9.5 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) FtsA PF14450.6 PIK43625.1 - 1.6 9.2 3.6 18 5.8 0.1 2.8 2 2 0 2 2 2 0 Cell division protein FtsA HSP70 PF00012.20 PIK43626.1 - 3.5e-57 193.9 5.5 3.9e-57 193.8 5.5 1.0 1 0 0 1 1 1 1 Hsp70 protein SQS_PSY PF00494.19 PIK43626.1 - 0.065 12.7 0.0 0.087 12.3 0.0 1.2 1 0 0 1 1 1 0 Squalene/phytoene synthase HEPN PF05168.14 PIK43626.1 - 0.069 13.3 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 HEPN domain SHS2_FTSA PF02491.20 PIK43626.1 - 0.49 10.8 2.9 2.1 8.8 0.2 2.5 1 1 1 2 2 2 0 SHS2 domain inserted in FTSA COesterase PF00135.28 PIK43627.1 - 4.1e-10 39.2 0.1 4.7e-10 39.0 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK43627.1 - 0.00014 21.5 4.1 0.00014 21.5 4.1 1.9 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Patched PF02460.18 PIK43628.1 - 1.1e-186 622.5 11.8 1.2e-186 622.3 11.8 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK43628.1 - 1.4e-40 138.6 8.9 1.4e-40 138.6 8.9 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Phage_C PF12025.8 PIK43628.1 - 0.02 14.8 0.2 0.049 13.5 0.2 1.6 1 0 0 1 1 1 0 Phage protein C MMPL PF03176.15 PIK43628.1 - 0.049 12.6 18.8 0.045 12.7 7.0 2.6 2 1 0 2 2 2 0 MMPL family XendoU PF09412.10 PIK43629.1 - 4.6e-61 206.3 3.0 6e-61 206.0 3.0 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK43629.1 - 0.0017 18.7 13.4 0.0031 17.9 13.4 1.4 1 0 0 1 1 1 1 Somatomedin B domain EndoU_bacteria PF14436.6 PIK43629.1 - 0.0043 17.4 0.0 0.0086 16.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial EndoU nuclease Reprolysin PF01421.19 PIK43630.1 - 4.5e-56 189.9 0.0 4.5e-56 189.9 0.0 1.5 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 PIK43630.1 - 4.2e-25 88.4 9.8 4.2e-25 88.4 9.8 2.7 2 1 0 2 2 1 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 PIK43630.1 - 5.7e-14 52.7 0.8 1.4e-13 51.4 0.8 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK43630.1 - 2.7e-13 50.5 0.3 4.8e-13 49.7 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK43630.1 - 3.9e-07 30.2 0.6 7e-07 29.3 0.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK43630.1 - 8.4e-07 28.8 0.1 1.5e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK43630.1 - 0.012 15.4 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 PIK43630.1 - 0.057 12.4 0.5 0.1 11.5 0.5 1.3 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 PIK43630.1 - 0.089 11.4 0.8 0.14 10.7 0.3 1.4 2 0 0 2 2 2 0 Putative peptidase family Pep_M12B_propep PF01562.19 PIK43630.1 - 0.12 12.6 0.1 0.29 11.3 0.1 1.7 1 0 0 1 1 1 0 Reprolysin family propeptide DUF3810 PF12725.7 PIK43630.1 - 0.4 10.0 1.3 0.71 9.2 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF716 PF04819.12 PIK43631.1 - 9.6e-25 86.8 5.8 1.8e-24 85.9 5.8 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF716) TRP PF06011.12 PIK43632.1 - 0.00064 18.6 14.7 0.0017 17.2 14.7 1.6 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel NIPSNAP PF07978.13 PIK43633.1 - 1.3e-30 105.7 2.2 5.3e-22 78.0 0.2 2.2 2 0 0 2 2 2 2 NIPSNAP GIY-YIG PF01541.24 PIK43634.1 - 6.3e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.9 PIK43634.1 - 0.0048 17.4 0.1 0.01 16.4 0.1 1.6 1 1 0 1 1 1 1 T5orf172 domain UCR_UQCRX_QCR9 PF05365.12 PIK43635.1 - 6.4e-21 74.1 0.3 7.1e-21 73.9 0.3 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GPCR_chapero_1 PF11904.8 PIK43636.1 - 2.2e-77 260.5 0.1 3e-77 260.1 0.1 1.1 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 PIK43636.1 - 1.9e-10 41.2 0.0 3.3e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43636.1 - 7.4e-09 36.0 0.0 1.4e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK43636.1 - 1.5e-08 34.7 0.0 1.8e-07 31.3 0.0 2.6 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK43636.1 - 7.3e-08 32.5 0.0 7e-07 29.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 PIK43636.1 - 7.6e-08 32.0 0.0 2.6e-05 24.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat TBD PF12845.7 PIK43636.1 - 0.13 12.2 3.1 0.28 11.1 0.0 2.9 3 0 0 3 3 3 0 TBD domain Pkinase PF00069.25 PIK43637.1 - 3.6e-45 154.4 0.1 4.4e-45 154.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43637.1 - 2.7e-28 99.0 0.1 3.2e-28 98.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK43637.1 - 3.4e-08 33.2 0.0 5.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK43637.1 - 0.00022 20.1 0.2 0.00032 19.6 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK43637.1 - 0.0012 17.9 0.1 0.002 17.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK43637.1 - 0.055 12.8 0.1 0.095 12.0 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IF-2B PF01008.17 PIK43638.1 - 3.2e-71 239.8 0.0 3.6e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ribosomal_L50 PF10501.9 PIK43639.1 - 1.9e-12 47.3 0.8 3.4e-12 46.5 0.8 1.4 1 0 0 1 1 1 1 Ribosomal subunit 39S RVT_1 PF00078.27 PIK43640.1 - 8.4e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zw10 PF06248.13 PIK43641.1 - 8.3e-21 74.1 5.9 1.4e-20 73.4 5.9 1.2 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Zw10 PF06248.13 PIK43642.1 - 4.6e-41 141.0 3.0 6.8e-35 120.6 0.4 3.2 3 0 0 3 3 3 3 Centromere/kinetochore Zw10 Focal_AT PF03623.13 PIK43642.1 - 0.074 13.0 0.0 2.5 8.1 0.4 2.6 2 1 0 2 2 2 0 Focal adhesion targeting region ZU5 PF00791.20 PIK43643.1 - 0.045 14.1 0.0 0.086 13.2 0.0 1.5 1 0 0 1 1 1 0 ZU5 domain ZU5 PF00791.20 PIK43644.1 - 3.7e-13 49.7 0.0 7.1e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK43644.1 - 3.1e-07 30.5 0.1 5.4e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Death domain UPA PF17217.3 PIK43644.1 - 0.00087 19.2 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 UPA domain NACHT PF05729.12 PIK43645.1 - 3.2e-13 50.0 0.0 8.6e-13 48.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK43645.1 - 0.00022 21.5 0.2 0.036 14.4 0.1 3.0 2 0 0 2 2 2 1 Death effector domain AAA PF00004.29 PIK43645.1 - 0.00079 19.9 0.0 0.0019 18.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 PIK43645.1 - 0.002 17.8 0.0 0.0059 16.2 0.0 1.8 1 1 1 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK43645.1 - 0.0037 16.6 0.0 0.0066 15.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 PIK43645.1 - 0.015 14.7 0.1 0.04 13.3 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 PIK43645.1 - 0.021 15.4 0.0 0.1 13.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK43645.1 - 0.045 14.0 0.0 0.17 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK43645.1 - 0.059 12.5 0.0 0.24 10.5 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.15 PIK43645.1 - 0.086 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Death PF00531.22 PIK43645.1 - 0.1 12.8 0.1 0.32 11.2 0.1 1.9 1 0 0 1 1 1 0 Death domain GAS PF13851.6 PIK43647.1 - 0.00025 20.5 53.4 0.00078 18.8 22.8 3.1 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK43647.1 - 0.00079 20.0 64.6 0.0052 17.3 23.1 3.8 2 1 2 4 4 4 3 Apg6 coiled-coil region Fez1 PF06818.15 PIK43647.1 - 0.0046 17.4 44.4 0.046 14.2 16.2 2.2 1 1 1 2 2 2 2 Fez1 KASH_CCD PF14662.6 PIK43647.1 - 0.0047 16.8 55.2 0.011 15.6 13.1 3.9 2 1 2 4 4 4 3 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 PIK43647.1 - 0.031 14.1 64.1 0.025 14.4 29.8 3.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family T3SSipB PF16535.5 PIK43647.1 - 0.052 14.0 26.1 0.18 12.3 15.3 3.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF4472 PF14739.6 PIK43647.1 - 0.076 13.7 46.2 0.2 12.4 6.5 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4472) Mei5 PF10376.9 PIK43647.1 - 0.17 11.7 33.1 1.8 8.3 20.1 2.5 1 1 1 2 2 2 0 Double-strand recombination repair protein PilA4 PF18682.1 PIK43647.1 - 0.18 12.2 14.1 11 6.5 0.1 4.7 1 1 4 5 5 5 0 Pilin A4 Sipho_Gp157 PF05565.11 PIK43647.1 - 0.28 11.2 37.8 0.4 10.7 3.7 5.0 2 2 2 4 4 4 0 Siphovirus Gp157 Caldesmon PF02029.15 PIK43647.1 - 0.62 8.8 37.9 1.1 8.0 37.9 1.4 1 0 0 1 1 1 0 Caldesmon GD_N PF16030.5 PIK43647.1 - 1.1 9.6 11.7 3.5 8.0 1.1 3.2 2 1 0 3 3 3 0 Serine protease gd N-terminus DUF1664 PF07889.12 PIK43647.1 - 1.5 8.9 25.2 0.44 10.6 5.5 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) FmiP_Thoc5 PF09766.9 PIK43647.1 - 1.5 8.0 46.6 0.81 8.9 17.5 2.9 2 1 1 3 3 3 0 Fms-interacting protein/Thoc5 DUF150_C PF17384.2 PIK43647.1 - 2.3 8.4 19.8 35 4.6 0.4 5.3 1 1 3 5 5 5 0 RimP C-terminal SH3 domain Nsp1_C PF05064.13 PIK43647.1 - 2.7 7.8 30.6 2 8.2 5.8 3.5 1 1 2 3 3 3 0 Nsp1-like C-terminal region Sulfotransfer_2 PF03567.14 PIK43647.1 - 3.4 7.5 15.0 0.31 10.9 1.3 2.3 1 1 1 2 2 2 0 Sulfotransferase family T2SSN PF01203.19 PIK43647.1 - 3.7 7.7 13.3 19 5.4 2.7 3.0 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein N DUF4600 PF15372.6 PIK43647.1 - 6.5 7.2 35.6 22 5.5 13.0 4.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4600) PfkB PF00294.24 PIK43647.1 - 6.9 5.9 7.7 45 3.2 0.3 3.4 1 1 3 4 4 4 0 pfkB family carbohydrate kinase DUF4172 PF13776.6 PIK43647.1 - 7.1 7.0 17.1 18 5.8 1.5 4.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4172) YkuI_C PF10388.9 PIK43647.1 - 8.9 6.1 15.2 2.9 7.7 3.2 2.7 1 1 1 2 2 2 0 EAL-domain associated signalling protein domain Mvb12 PF09452.10 PIK43647.1 - 9.3 6.8 10.0 11 6.5 1.2 3.2 1 1 2 3 3 3 0 ESCRT-I subunit Mvb12 Mito_carr PF00153.27 PIK43648.1 - 1.4e-25 89.0 0.0 1.1e-17 63.7 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein zf-B_box PF00643.24 PIK43649.1 - 1.5e-12 47.5 21.0 2.1e-09 37.4 4.9 3.5 3 0 0 3 3 3 2 B-box zinc finger fn3 PF00041.21 PIK43649.1 - 4.9e-08 33.2 0.2 1.2e-07 32.0 0.2 1.7 1 0 0 1 1 1 1 Fibronectin type III domain SPRY PF00622.28 PIK43649.1 - 0.042 14.0 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 SPRY domain fn3_2 PF16893.5 PIK43649.1 - 0.15 12.2 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III domain FYVE_2 PF02318.16 PIK43649.1 - 1 9.6 9.8 5.5 7.2 1.1 3.2 3 0 0 3 3 3 0 FYVE-type zinc finger IBR PF01485.21 PIK43649.1 - 2 8.7 24.5 0.03 14.5 2.9 3.7 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain zf-piccolo PF05715.13 PIK43649.1 - 9.4 6.5 15.7 5.3 7.3 2.1 3.2 3 0 0 3 3 3 0 Piccolo Zn-finger NHL PF01436.21 PIK43651.1 - 0.00014 21.7 0.0 0.0035 17.3 0.0 3.2 3 0 0 3 3 3 1 NHL repeat SdiA-regulated PF06977.11 PIK43651.1 - 0.012 14.8 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 SdiA-regulated Ldl_recept_b PF00058.17 PIK43652.1 - 4.9e-25 87.7 3.7 3.8e-14 52.9 0.1 3.6 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK43652.1 - 0.0069 16.0 0.1 0.33 10.5 0.1 2.2 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 PIK43653.1 - 3.7e-18 65.7 3.5 2e-12 47.4 0.1 3.4 3 0 0 3 3 3 2 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.15 PIK43653.1 - 4.5e-09 36.4 6.5 4.5e-09 36.4 6.5 3.3 2 1 1 3 3 3 1 Calcium-binding EGF domain Ldl_recept_a PF00057.18 PIK43653.1 - 2.8e-06 27.4 4.4 2.8e-06 27.4 4.4 3.1 2 1 1 3 3 3 1 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK43653.1 - 3e-05 23.8 8.8 0.00017 21.4 0.8 3.9 4 0 0 4 4 4 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK43653.1 - 0.0029 17.9 5.4 0.0029 17.9 5.4 3.6 2 1 1 3 3 3 1 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK43653.1 - 0.017 14.7 0.1 0.48 10.0 0.0 2.3 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region EGF_3 PF12947.7 PIK43653.1 - 0.035 14.3 1.8 0.035 14.3 1.8 3.4 3 2 1 4 4 4 0 EGF domain EGF_MSP1_1 PF12946.7 PIK43653.1 - 0.041 13.9 1.0 0.041 13.9 1.0 3.0 3 0 0 3 3 3 0 MSP1 EGF domain 1 Ldl_recept_a PF00057.18 PIK43654.1 - 2.6e-30 104.3 48.8 5.6e-12 45.7 15.8 3.2 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 PIK43654.1 - 0.0039 17.0 34.3 0.17 11.7 18.5 2.3 1 1 1 2 2 2 2 Glucosidase II beta subunit-like Helicase_C PF00271.31 PIK43655.1 - 0.002 18.5 0.1 0.002 18.5 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SecA_PP_bind PF01043.20 PIK43655.1 - 0.027 15.1 0.0 0.12 13.0 0.0 2.2 1 0 0 1 1 1 0 SecA preprotein cross-linking domain DUF2172 PF09940.9 PIK43655.1 - 0.033 14.6 0.6 1.4 9.4 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2172) HSBP1 PF06825.12 PIK43655.1 - 0.052 13.4 0.2 4.9 7.1 0.0 2.7 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Phage_TAC_3 PF06896.11 PIK43655.1 - 4.5 7.9 9.2 0.15 12.6 0.4 3.0 4 0 0 4 4 4 0 Phage tail assembly chaperone proteins, TAC Fibrinogen_C PF00147.18 PIK43656.1 - 1.6e-36 126.2 2.3 2.2e-36 125.7 2.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK43656.1 - 9.3e-05 22.5 14.3 0.00011 22.3 9.9 2.7 1 1 1 2 2 2 1 EGF domain COLFI PF01410.18 PIK43656.1 - 0.012 15.0 0.2 0.017 14.4 0.2 1.3 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain EGF PF00008.27 PIK43656.1 - 0.017 15.4 5.1 0.017 15.4 5.1 2.6 2 1 1 3 3 3 0 EGF-like domain cEGF PF12662.7 PIK43656.1 - 0.024 14.6 3.0 0.024 14.6 3.0 2.3 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK43656.1 - 0.036 14.3 13.6 0.12 12.6 9.4 2.5 2 0 0 2 2 2 0 Calcium-binding EGF domain EGF_2 PF07974.13 PIK43656.1 - 0.3 11.5 13.5 0.42 11.0 9.5 2.5 2 0 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK43656.1 - 0.83 9.8 8.2 3.4 7.8 8.2 2.1 1 1 0 1 1 1 0 MSP1 EGF domain 1 hEGF PF12661.7 PIK43656.1 - 1.3 9.8 7.9 0.78 10.5 4.6 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK43656.1 - 3.8 7.9 13.4 17 5.8 13.4 2.2 1 1 0 1 1 1 0 Coagulation Factor Xa inhibitory site Glyco_transf_64 PF09258.10 PIK43657.1 - 4.9e-96 320.8 0.6 7.7e-96 320.1 0.6 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 PIK43657.1 - 6.4e-53 179.9 0.0 8.7e-53 179.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Glyco_tranf_2_3 PF13641.6 PIK43657.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Biopterin_H PF00351.21 PIK43658.1 - 7.8e-168 557.7 1.8 1e-167 557.3 1.8 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 PIK43658.1 - 0.017 14.9 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 ACT domain DUF1251 PF06856.11 PIK43658.1 - 0.047 13.4 0.2 15 5.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1251) Neur_chan_LBD PF02931.23 PIK43659.1 - 4.8e-85 284.4 12.0 9.9e-44 149.4 2.0 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK43659.1 - 1.2e-29 104.1 19.5 1.5e-20 74.3 0.1 3.2 3 0 0 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region DUF3519 PF12033.8 PIK43660.1 - 6 7.3 9.7 4 7.9 2.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3519) Zona_pellucida PF00100.23 PIK43662.1 - 1.9e-19 70.5 0.5 2.5e-19 70.1 0.5 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain COX2_TM PF02790.15 PIK43662.1 - 0.018 15.2 0.2 0.037 14.2 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain Zona_pellucida PF00100.23 PIK43663.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Zona pellucida-like domain TFIIS_M PF07500.14 PIK43664.1 - 2.3e-25 89.2 0.5 3.4e-25 88.7 0.5 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 PIK43664.1 - 2.6e-18 65.6 7.5 3.8e-18 65.0 7.5 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) zf-ribbon_3 PF13248.6 PIK43664.1 - 0.074 12.5 3.3 4 7.0 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 PIK43664.1 - 0.26 10.9 3.6 0.67 9.5 3.6 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 PIK43664.1 - 1 9.1 10.9 2.4 8.0 0.8 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 PIK43664.1 - 1.4 8.7 4.7 0.64 9.7 0.4 2.2 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_13 PF09855.9 PIK43664.1 - 8.7 6.6 13.3 2.1e+02 2.2 0.1 3.5 2 2 1 3 3 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Med26 PF08711.11 PIK43665.1 - 5.1e-07 29.6 1.3 1.1e-06 28.5 1.3 1.8 1 1 0 1 1 1 1 TFIIS helical bundle-like domain TFIIS_M PF07500.14 PIK43665.1 - 0.00047 20.6 0.8 0.0012 19.3 0.0 1.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Smg8_Smg9 PF10220.9 PIK43665.1 - 0.038 12.3 0.5 0.042 12.2 0.5 1.1 1 0 0 1 1 1 0 Smg8_Smg9 ICAP-1_inte_bdg PF10480.9 PIK43666.1 - 3e-11 43.7 0.0 3.6e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.23 PIK43666.1 - 0.12 12.4 0.3 0.3 11.1 0.3 1.7 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Ig_3 PF13927.6 PIK43667.1 - 1.1e-22 80.4 13.2 0.00036 21.1 0.0 8.5 9 0 0 9 9 9 6 Immunoglobulin domain I-set PF07679.16 PIK43667.1 - 7.7e-19 67.6 0.1 0.018 15.1 0.0 6.8 7 0 0 7 7 7 5 Immunoglobulin I-set domain Laminin_G_3 PF13385.6 PIK43667.1 - 3.4e-16 59.7 0.9 3.4e-16 59.7 0.9 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Mucin2_WxxW PF13330.6 PIK43667.1 - 1.3e-15 58.0 6.6 2.2e-11 44.4 2.3 3.0 2 0 0 2 2 2 2 Mucin-2 protein WxxW repeating region Ig_2 PF13895.6 PIK43667.1 - 5.3e-10 39.5 6.4 0.16 12.3 0.0 7.4 6 1 0 6 6 6 3 Immunoglobulin domain ig PF00047.25 PIK43667.1 - 3.1e-07 30.5 12.9 0.045 13.9 0.0 7.1 7 2 0 7 7 7 3 Immunoglobulin domain F5_F8_type_C PF00754.25 PIK43667.1 - 1.2e-05 25.4 0.0 4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 F5/8 type C domain zf-RRN7 PF11781.8 PIK43667.1 - 0.68 9.7 3.4 21 4.9 0.4 3.4 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Mucin2_WxxW PF13330.6 PIK43668.1 - 1e-13 51.9 7.2 1.7e-13 51.2 7.2 1.3 1 0 0 1 1 1 1 Mucin-2 protein WxxW repeating region UPF0506 PF11703.8 PIK43668.1 - 2.6 8.5 6.5 6.2 7.3 6.5 1.8 1 0 0 1 1 1 0 UPF0506 Mucin2_WxxW PF13330.6 PIK43669.1 - 2.9e-35 121.0 12.1 7.2e-21 74.8 1.9 2.8 2 0 0 2 2 2 2 Mucin-2 protein WxxW repeating region I-set PF07679.16 PIK43669.1 - 5.3e-32 109.8 0.7 0.00075 19.5 0.0 10.3 10 0 0 10 10 10 6 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK43669.1 - 7.1e-28 97.0 34.7 0.00039 21.0 0.0 12.2 12 0 0 12 12 12 7 Immunoglobulin domain Laminin_G_3 PF13385.6 PIK43669.1 - 8.7e-25 87.6 3.0 9.3e-16 58.3 1.5 3.6 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily V-set PF07686.17 PIK43669.1 - 2.8e-10 40.3 3.1 2 8.6 0.0 7.6 7 1 0 7 7 7 4 Immunoglobulin V-set domain ig PF00047.25 PIK43669.1 - 3.2e-06 27.2 19.5 1.1 9.5 0.4 8.5 9 1 0 9 9 9 4 Immunoglobulin domain F5_F8_type_C PF00754.25 PIK43669.1 - 5.9e-05 23.2 1.3 0.00018 21.7 0.0 2.5 3 0 0 3 3 3 1 F5/8 type C domain Ig_2 PF13895.6 PIK43669.1 - 0.001 19.3 13.3 0.48 10.8 0.0 8.3 9 0 0 9 9 9 1 Immunoglobulin domain Protocadherin PF08374.11 PIK43669.1 - 0.0062 16.5 1.0 32 4.4 0.0 3.4 3 0 0 3 3 3 0 Protocadherin Spatacsin_C PF14649.6 PIK43671.1 - 1e-85 287.6 4.6 1e-85 287.6 4.6 1.8 2 0 0 2 2 2 1 Spatacsin C-terminus FmdE PF02663.14 PIK43673.1 - 0.14 12.2 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon MFS_1 PF07690.16 PIK43674.1 - 1.9e-12 46.8 27.2 1.9e-12 46.8 27.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 PIK43674.1 - 0.069 13.0 0.4 2 8.3 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 LRR_8 PF13855.6 PIK43675.1 - 1e-63 211.0 53.9 8.4e-12 44.7 7.4 10.7 3 1 8 11 11 11 11 Leucine rich repeat LRR_5 PF13306.6 PIK43675.1 - 2.9e-45 153.4 47.7 6.5e-16 58.5 2.0 5.3 1 1 5 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK43675.1 - 3.5e-24 84.5 56.8 7.3e-05 23.1 4.5 11.1 5 3 6 13 13 13 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK43675.1 - 1.8e-09 37.3 25.4 0.031 13.8 2.9 7.0 1 1 4 6 6 6 4 Leucine-rich repeat T6SS_VipA PF05591.12 PIK43675.1 - 0.066 13.0 3.0 16 5.2 0.0 3.4 3 0 0 3 3 3 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 NCD3G PF07562.14 PIK43675.1 - 0.32 11.0 19.9 0.44 10.6 1.7 3.5 2 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Pkinase PF00069.25 PIK43676.1 - 3.8e-42 144.5 0.0 5.9e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43676.1 - 4.9e-20 71.9 0.0 7.4e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK43676.1 - 0.0059 15.9 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF4834 PF16118.5 PIK43676.1 - 0.15 13.1 0.2 1.8 9.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) NACHT PF05729.12 PIK43677.1 - 1.9e-08 34.4 0.0 3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK43677.1 - 3.4e-05 23.5 0.0 6.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK43677.1 - 0.0015 18.8 0.0 0.0027 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK43677.1 - 0.14 12.2 0.0 0.54 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK43677.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Aldo_ket_red PF00248.21 PIK43678.1 - 0.14 11.4 0.0 0.29 10.3 0.0 1.6 1 0 0 1 1 1 0 Aldo/keto reductase family Kelch_4 PF13418.6 PIK43678.1 - 0.15 12.1 0.1 1.2 9.2 0.0 2.5 3 0 0 3 3 3 0 Galactose oxidase, central domain NACHT PF05729.12 PIK43679.1 - 7.1e-12 45.6 0.0 1.3e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK43679.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK43679.1 - 0.034 14.4 0.0 0.089 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Reeler PF02014.16 PIK43680.1 - 0.058 14.2 0.0 4.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Reeler domain Ten1 PF12658.7 PIK43680.1 - 0.061 13.3 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Telomere capping, CST complex subunit Ig_3 PF13927.6 PIK43681.1 - 1.3e-07 32.2 0.5 0.0021 18.6 0.3 3.4 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK43681.1 - 2.3e-06 27.8 0.4 0.14 12.5 0.2 3.1 2 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK43681.1 - 1.9e-05 24.6 0.2 5.6e-05 23.1 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK43681.1 - 0.00016 21.8 0.2 3 8.0 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin V-set domain ig PF00047.25 PIK43681.1 - 0.00027 21.1 0.2 0.23 11.7 0.5 3.3 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK43681.1 - 0.0021 18.1 0.1 1.1 9.3 0.0 3.0 3 1 0 3 3 3 2 Immunoglobulin I-set domain adh_short PF00106.25 PIK43682.1 - 1.2e-45 155.4 0.2 1.6e-45 155.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK43682.1 - 6.8e-36 124.0 0.1 9.2e-36 123.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK43682.1 - 9.6e-09 35.4 0.3 1.8e-08 34.5 0.3 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK43682.1 - 6e-06 25.6 0.6 2.5e-05 23.6 0.2 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK43682.1 - 6.9e-05 22.4 0.1 0.00017 21.1 0.1 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK43682.1 - 0.00012 21.6 0.0 0.00018 21.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 PIK43682.1 - 0.0021 17.1 0.3 0.0029 16.7 0.3 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK43682.1 - 0.063 13.2 0.1 0.87 9.5 0.0 2.3 2 0 0 2 2 2 0 NAD(P)H-binding Ldl_recept_b PF00058.17 PIK43683.1 - 1.6e-35 121.3 7.0 3.2e-10 40.3 0.1 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B HYR PF02494.16 PIK43683.1 - 8e-12 45.3 4.7 4.4e-05 23.7 0.2 2.6 2 0 0 2 2 2 2 HYR domain SGL PF08450.12 PIK43683.1 - 9.1e-08 32.0 0.9 0.00068 19.3 0.1 2.7 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 PIK43683.1 - 2.2e-05 23.8 0.0 0.00031 20.1 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF5050) FXa_inhibition PF14670.6 PIK43683.1 - 0.0014 18.9 2.8 0.0014 18.9 2.8 2.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site Arylesterase PF01731.20 PIK43683.1 - 0.029 14.5 0.1 35 4.7 0.0 3.6 3 1 1 4 4 4 0 Arylesterase Cadherin PF00028.17 PIK43683.1 - 0.14 12.6 0.1 11 6.6 0.0 2.8 3 0 0 3 3 3 0 Cadherin domain Acyl_transf_3 PF01757.22 PIK43684.1 - 6.3e-07 28.8 54.6 2.4e-06 26.9 49.2 2.9 2 1 0 2 2 2 1 Acyltransferase family Acyl_transf_3 PF01757.22 PIK43685.1 - 1.7e-19 70.1 46.6 1.7e-19 70.1 46.6 1.8 2 0 0 2 2 2 1 Acyltransferase family DUF418 PF04235.12 PIK43685.1 - 0.0066 16.4 1.3 0.0066 16.4 1.3 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF418) AAA PF00004.29 PIK43686.1 - 1.2e-42 145.5 0.0 1.8e-42 144.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 PIK43686.1 - 3.7e-10 40.1 0.1 1.8e-09 37.9 0.0 2.2 3 0 0 3 3 3 1 FtsH Extracellular AAA_5 PF07728.14 PIK43686.1 - 0.0022 18.0 0.0 0.0051 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 PIK43686.1 - 0.0022 18.1 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK43686.1 - 0.0031 17.8 0.1 0.13 12.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 PIK43686.1 - 0.0045 16.2 0.0 0.0069 15.6 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 PIK43686.1 - 0.017 14.9 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK43686.1 - 0.018 15.4 0.1 0.12 12.8 0.1 2.0 1 1 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 PIK43686.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 PIK43686.1 - 0.13 11.6 0.6 0.28 10.5 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 PIK43686.1 - 0.17 11.2 0.1 0.46 9.7 0.0 1.7 1 1 1 2 2 2 0 Zeta toxin AAA_33 PF13671.6 PIK43686.1 - 0.18 11.9 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Peptidase_M41 PF01434.18 PIK43687.1 - 2.2e-67 226.6 0.0 3.3e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA_lid_3 PF17862.1 PIK43687.1 - 6.3e-12 45.1 0.0 1.4e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Sec7 PF01369.20 PIK43687.1 - 0.037 13.7 0.2 0.065 12.9 0.1 1.5 2 0 0 2 2 2 0 Sec7 domain zf-H2C2_5 PF13909.6 PIK43688.1 - 1.7e-20 72.5 62.0 8.8e-07 28.6 1.9 8.4 8 1 0 8 8 8 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK43688.1 - 3.2e-18 65.1 66.3 0.0037 17.6 2.7 9.2 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK43688.1 - 4.7e-12 45.8 51.6 0.00011 22.5 2.4 9.5 10 0 0 10 10 10 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK43688.1 - 4.2e-10 39.6 59.5 0.2 12.6 0.0 9.5 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK43688.1 - 0.007 16.3 0.0 0.007 16.3 0.0 6.2 8 1 0 8 8 8 1 C2H2-type zinc finger zf-Di19 PF05605.12 PIK43688.1 - 0.041 14.2 37.2 0.041 14.2 2.6 5.4 5 1 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding DUF809 PF05663.11 PIK43688.1 - 0.51 10.5 4.2 1.4 9.1 4.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF809) OrsD PF12013.8 PIK43688.1 - 7.5 7.0 37.0 6.4 7.3 1.6 6.1 3 1 2 5 5 5 0 Orsellinic acid/F9775 biosynthesis cluster protein D ARID PF01388.21 PIK43689.1 - 9.5e-10 39.0 0.0 1.3e-08 35.4 0.0 2.5 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain JmjC PF02373.22 PIK43689.1 - 1.2e-07 32.2 0.0 8.5e-07 29.4 0.1 2.5 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 PIK43689.1 - 6.5e-07 29.2 0.0 1.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 jmjN domain ATG16 PF08614.11 PIK43690.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-C5HC2 PF02928.16 PIK43691.1 - 1.1e-05 25.7 0.0 1.6e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 C5HC2 zinc finger TcpS PF17456.2 PIK43691.1 - 0.15 12.1 1.9 0.63 10.1 1.6 1.8 1 1 1 2 2 2 0 Toxin-coregulated pilus protein S SPT16 PF08644.11 PIK43692.1 - 6.3e-59 198.5 0.1 6.3e-59 198.5 0.1 2.6 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 PIK43692.1 - 4.1e-48 163.2 1.2 4.1e-48 163.2 1.2 2.1 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 PIK43692.1 - 2.8e-18 66.4 0.0 5.1e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 PIK43692.1 - 8.6e-18 64.6 0.0 2.2e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like eIF-5a PF01287.20 PIK43692.1 - 0.016 15.3 0.2 2.1 8.5 0.1 3.2 3 0 0 3 3 3 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold SRCR PF00530.18 PIK43693.1 - 5.5e-18 65.3 0.0 1.8e-07 31.6 0.0 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain DUF4841 PF16129.5 PIK43693.1 - 0.044 14.0 0.0 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4841) DUF4223 PF13978.6 PIK43693.1 - 0.28 11.2 1.1 0.75 9.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4223) DUF4764 PF15961.5 PIK43694.1 - 0.034 12.8 0.1 0.054 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) COG4 PF08318.12 PIK43695.1 - 1.4e-91 307.1 2.4 2.3e-91 306.4 2.4 1.4 1 0 0 1 1 1 1 COG4 transport protein Sec10 PF07393.11 PIK43695.1 - 7.9e-06 24.6 0.3 2.5e-05 22.9 0.3 1.9 1 0 0 1 1 1 1 Exocyst complex component Sec10 DIL PF01843.19 PIK43695.1 - 0.0012 19.0 0.3 3.8 7.8 0.0 3.1 2 0 0 2 2 2 2 DIL domain Seryl_tRNA_N PF02403.22 PIK43695.1 - 0.022 15.0 1.0 0.22 11.8 0.4 2.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4268 PF14088.6 PIK43695.1 - 0.033 14.1 0.1 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4268) DUF4795 PF16043.5 PIK43695.1 - 0.037 13.6 1.7 0.11 12.1 1.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Ribosomal_L22 PF00237.19 PIK43695.1 - 0.091 13.0 0.4 15 5.9 0.1 3.0 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e Sec34 PF04136.15 PIK43695.1 - 0.12 12.3 3.1 2.7 7.9 0.6 3.0 2 1 0 2 2 2 0 Sec34-like family Baculo_PEP_C PF04513.12 PIK43695.1 - 3 7.9 6.7 1.7 8.7 0.1 3.4 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PhnA_Zn_Ribbon PF08274.12 PIK43697.1 - 0.00045 20.1 0.4 0.00084 19.2 0.4 1.3 1 0 0 1 1 1 1 PhnA Zinc-Ribbon Aph-1 PF06105.12 PIK43698.1 - 5.5e-79 264.8 13.9 6.3e-79 264.6 13.9 1.0 1 0 0 1 1 1 1 Aph-1 protein Baculo_PEP_C PF04513.12 PIK43699.1 - 0.0028 17.7 25.0 0.94 9.5 1.1 4.4 1 1 3 4 4 4 4 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1319 PF07028.11 PIK43699.1 - 6.2 7.1 26.6 3.5 7.9 3.7 4.4 2 2 1 4 4 4 0 Protein of unknown function (DUF1319) Tetraspanin PF00335.20 PIK43700.1 - 5.2e-32 111.4 13.1 5.2e-32 111.4 13.1 1.4 2 0 0 2 2 2 1 Tetraspanin family Phage_holin_3_6 PF07332.11 PIK43700.1 - 0.024 14.7 7.2 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4131 PF13567.6 PIK43700.1 - 0.89 9.2 3.2 1.1 8.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Baculo_11_kDa PF06143.11 PIK43700.1 - 1.6 8.4 4.3 18 5.0 0.1 3.2 3 1 1 4 4 4 0 Baculovirus 11 kDa family Tim44 PF04280.15 PIK43701.1 - 2.9e-44 150.7 0.0 2.9e-44 150.7 0.0 2.2 4 0 0 4 4 4 1 Tim44-like domain AKNA PF12443.8 PIK43701.1 - 0.45 11.2 8.6 0.39 11.4 3.7 2.9 3 0 0 3 3 3 0 AT-hook-containing transcription factor DUF2937 PF11157.8 PIK43701.1 - 1.9 8.2 4.7 2.9 7.6 3.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) Neur_chan_memb PF02932.16 PIK43701.1 - 7.9 6.5 8.5 13 5.7 8.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2039 PF10217.9 PIK43702.1 - 4.3e-31 107.1 23.6 7e-31 106.4 23.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) CRA PF06589.11 PIK43702.1 - 0.41 10.7 10.8 0.11 12.6 5.1 2.2 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) zinc-ribbons_6 PF07191.12 PIK43702.1 - 1.5 8.8 13.5 0.89 9.6 7.9 2.0 1 1 0 1 1 1 0 zinc-ribbons Cript PF10235.9 PIK43702.1 - 4 8.1 24.6 40 4.9 24.6 2.2 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT SIR2 PF02146.17 PIK43703.1 - 1e-28 100.4 0.1 1.2e-20 74.1 0.0 2.2 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 PIK43703.1 - 0.0013 18.5 0.0 0.0076 16.0 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Toxin_6 PF05453.12 PIK43703.1 - 0.028 14.8 0.2 0.12 12.8 0.2 2.2 1 0 0 1 1 1 0 BmTXKS1/BmP02 toxin family RBP_receptor PF14752.6 PIK43704.1 - 1.1e-97 328.1 8.5 4.7e-81 273.2 2.6 2.1 1 1 1 2 2 2 2 Retinol binding protein receptor DUF243 PF03103.17 PIK43704.1 - 0.013 15.8 4.4 0.013 15.8 4.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF243) 7tm_1 PF00001.21 PIK43705.1 - 1.4e-48 165.6 22.7 1.9e-48 165.1 22.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43705.1 - 6.9e-10 38.7 22.7 9.6e-10 38.3 22.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3810 PF12725.7 PIK43705.1 - 2.5 7.3 12.1 0.07 12.5 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Frataxin_Cyay PF01491.16 PIK43706.1 - 5.3e-37 126.2 0.1 8e-37 125.6 0.1 1.3 1 0 0 1 1 1 1 Frataxin-like domain Nro1 PF12753.7 PIK43706.1 - 0.051 12.5 0.1 0.066 12.2 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 PAP_assoc PF03828.19 PIK43707.1 - 5e-07 29.8 0.9 2.4e-06 27.7 0.9 2.2 1 1 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 PIK43707.1 - 8.1e-07 29.3 1.4 0.0087 16.3 0.0 3.5 2 1 1 3 3 3 2 Nucleotidyltransferase domain Polbeta PF18765.1 PIK43707.1 - 0.05 13.7 0.3 14 5.8 0.1 2.6 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase CENP-H PF05837.12 PIK43709.1 - 2.1e-23 82.9 6.2 2.4e-23 82.7 6.2 1.0 1 0 0 1 1 1 1 Centromere protein H (CENP-H) Taxilin PF09728.9 PIK43709.1 - 1.2e-05 24.7 7.7 1.4e-05 24.5 7.7 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein TMPIT PF07851.13 PIK43709.1 - 0.0046 16.2 5.8 0.0055 16.0 5.8 1.0 1 0 0 1 1 1 1 TMPIT-like protein HAUS-augmin3 PF14932.6 PIK43709.1 - 0.017 14.7 5.5 0.017 14.7 5.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF3450 PF11932.8 PIK43709.1 - 0.02 14.2 6.4 0.024 13.9 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Mto2_bdg PF12808.7 PIK43709.1 - 0.021 15.1 5.0 0.15 12.4 0.1 2.5 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Spc7 PF08317.11 PIK43709.1 - 0.046 12.6 7.6 0.055 12.3 7.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RNA_polI_A14 PF08203.11 PIK43709.1 - 0.054 14.2 2.0 0.09 13.5 2.0 1.4 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 OmpH PF03938.14 PIK43709.1 - 0.061 13.7 9.3 0.08 13.3 9.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 PIK43709.1 - 0.061 12.7 2.8 0.074 12.4 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 PIK43709.1 - 0.11 11.1 3.7 0.12 10.9 3.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 PIK43709.1 - 0.12 13.1 6.3 0.15 12.7 6.3 1.2 1 0 0 1 1 1 0 Initiation control protein YabA JIP_LZII PF16471.5 PIK43709.1 - 0.21 11.8 7.3 0.24 11.6 5.8 2.0 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II BRX_N PF13713.6 PIK43709.1 - 0.24 11.2 2.2 3.8 7.4 0.1 2.3 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain Tho2 PF11262.8 PIK43709.1 - 0.27 10.4 4.8 0.32 10.1 4.8 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Dicty_REP PF05086.12 PIK43709.1 - 0.34 8.8 3.7 0.38 8.7 3.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TMF_TATA_bd PF12325.8 PIK43709.1 - 0.41 10.9 12.4 1 9.6 12.3 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 PIK43709.1 - 0.42 8.5 2.8 0.45 8.4 2.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 PIK43709.1 - 0.6 10.6 16.4 2.9 8.4 6.5 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region UPF0242 PF06785.11 PIK43709.1 - 0.63 10.1 9.7 0.87 9.7 9.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SKA2 PF16740.5 PIK43709.1 - 0.66 9.8 9.2 1.3 8.9 9.3 1.5 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF2968 PF11180.8 PIK43709.1 - 2.6 7.7 12.7 3.9 7.1 12.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) CENP-B_dimeris PF09026.10 PIK43710.1 - 0.0015 18.9 2.9 0.0015 18.9 2.9 2.6 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Cylicin_N PF15241.6 PIK43711.1 - 0.29 11.3 5.9 3.7 7.7 0.2 2.2 2 0 0 2 2 2 0 Cylicin N-terminus BRCT_3 PF18428.1 PIK43713.1 - 3.7e-30 104.0 0.0 8.5e-27 93.2 0.2 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 PIK43713.1 - 4.3e-07 30.2 0.0 0.0092 16.3 0.0 2.8 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK43713.1 - 1.3e-06 28.8 0.0 0.0077 16.6 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DUF1325 PF07039.11 PIK43713.1 - 1.6e-06 28.3 0.1 1.8e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 SGF29 tudor-like domain RTT107_BRCT_5 PF16770.5 PIK43713.1 - 6.7e-05 22.7 0.0 0.00021 21.1 0.0 1.9 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain DUF4537 PF15057.6 PIK43713.1 - 0.0001 22.3 0.1 0.00029 20.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.10 PIK43713.1 - 0.00029 20.8 0.1 0.00062 19.7 0.1 1.5 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor LBR_tudor PF09465.10 PIK43713.1 - 0.0038 17.0 0.1 0.0094 15.7 0.1 1.6 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain PTCB-BRCT PF12738.7 PIK43713.1 - 0.0057 16.6 0.1 0.76 9.8 0.0 2.6 2 0 0 2 2 2 1 twin BRCT domain Tudor_2 PF18104.1 PIK43713.1 - 0.018 14.7 0.1 0.086 12.5 0.0 2.1 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain Filament PF00038.21 PIK43714.1 - 6.7e-28 98.2 23.9 1.6e-26 93.6 23.9 2.1 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 PIK43714.1 - 4.1e-05 23.9 0.0 0.0001 22.6 0.0 1.6 1 0 0 1 1 1 1 Lamin Tail Domain Transposase_1 PF01359.18 PIK43714.1 - 0.019 14.8 0.7 0.33 10.8 0.1 2.7 2 0 0 2 2 2 0 Transposase (partial DDE domain) Antimicrobial23 PF16048.5 PIK43714.1 - 0.24 11.1 3.6 0.43 10.3 3.6 1.4 1 0 0 1 1 1 0 Frog antimicrobial peptide Tmemb_cc2 PF10267.9 PIK43714.1 - 0.25 10.4 13.1 0.36 9.9 12.4 1.5 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 PIK43714.1 - 0.55 9.1 6.8 0.72 8.7 6.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2408 PF10303.9 PIK43714.1 - 1.2 9.7 12.5 3.2 8.3 12.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Troponin PF00992.20 PIK43714.1 - 1.8 8.9 17.9 0.059 13.7 2.2 2.4 2 1 0 2 2 2 0 Troponin Ribosomal_S11 PF00411.19 PIK43715.1 - 7.9e-05 23.0 0.3 9e-05 22.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 RhoGEF67_u2 PF16614.5 PIK43715.1 - 0.0067 16.5 0.0 0.0083 16.2 0.0 1.0 1 0 0 1 1 1 1 Unstructured region two on RhoGEF 6 and 7 Il13Ra_Ig PF18001.1 PIK43716.1 - 0.042 13.9 0.0 0.07 13.2 0.0 1.3 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain BTB_2 PF02214.22 PIK43717.1 - 4.2e-18 65.5 0.1 6.5e-18 64.9 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK43717.1 - 0.054 13.7 0.1 0.091 13.0 0.1 1.4 1 0 0 1 1 1 0 BTB/POZ domain OTU PF02338.19 PIK43718.1 - 1.7e-30 106.1 1.2 4.6e-30 104.7 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 PIK43718.1 - 2.2e-08 33.9 9.3 1.5e-05 24.6 0.0 3.0 1 1 2 3 3 3 2 Peptidase C65 Otubain dCache_1 PF02743.18 PIK43718.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Cache domain Hid1 PF12722.7 PIK43718.1 - 1.3 7.0 10.9 2 6.5 10.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 PIK43718.1 - 4.4 5.1 18.0 5 4.9 18.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPTA PF01239.22 PIK43719.1 - 1.7e-36 122.9 15.8 2.9e-09 36.3 0.3 5.7 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat RabGGT_insert PF07711.11 PIK43719.1 - 0.00023 21.6 1.6 0.00052 20.5 0.5 2.2 3 0 0 3 3 3 1 Rab geranylgeranyl transferase alpha-subunit, insert domain XhlA PF10779.9 PIK43719.1 - 0.19 11.9 3.5 0.32 11.2 0.2 2.4 2 0 0 2 2 2 0 Haemolysin XhlA CBF_beta PF02312.17 PIK43720.1 - 1.4e-14 54.1 2.0 1.5e-14 54.0 2.0 1.0 1 0 0 1 1 1 1 Core binding factor beta subunit TPR_17 PF13431.6 PIK43722.1 - 1.8e-10 40.4 0.1 0.056 13.8 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK43722.1 - 3.1e-09 36.3 5.6 0.17 11.8 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43722.1 - 3.4e-08 33.0 6.5 0.42 10.8 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43722.1 - 5e-06 26.1 0.7 0.37 10.5 0.0 4.2 4 1 0 4 4 4 2 TPR repeat TPR_8 PF13181.6 PIK43722.1 - 5.4e-05 23.1 4.6 0.34 11.2 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43722.1 - 8.4e-05 23.0 0.5 1.4 9.5 0.0 4.1 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43722.1 - 0.00018 21.7 0.2 1.3 9.4 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43722.1 - 0.0062 16.7 5.1 1.4 9.2 0.3 3.5 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 PIK43722.1 - 0.03 15.1 0.2 32 5.7 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43722.1 - 0.033 14.2 0.2 1.5 9.0 0.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat AXH PF08517.12 PIK43723.1 - 3.4e-10 40.5 1.3 5.3e-10 39.9 0.2 1.9 2 0 0 2 2 2 1 Ataxin-1 and HBP1 module (AXH) zf-CCCH_4 PF18044.1 PIK43725.1 - 2.9e-10 39.7 3.3 4.3e-10 39.2 3.3 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 PIK43725.1 - 9.3e-07 28.7 5.2 1.4e-06 28.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 PIK43725.1 - 9.2e-06 26.3 2.8 1.8e-05 25.4 0.0 2.6 3 0 0 3 3 3 1 Torus domain zf-CCCH PF00642.24 PIK43725.1 - 1.1e-05 25.2 1.8 1.9e-05 24.4 1.8 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 PIK43725.1 - 0.043 14.3 4.6 0.072 13.6 4.6 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Macoilin PF09726.9 PIK43725.1 - 1.3 7.5 6.2 1.7 7.1 6.2 1.2 1 0 0 1 1 1 0 Macoilin family UCR_TM PF02921.14 PIK43726.1 - 8.7e-26 90.2 0.3 1.6e-25 89.3 0.3 1.5 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Ubiq-Cytc-red_N PF09165.10 PIK43726.1 - 8.1e-15 55.5 4.9 1.3e-14 54.8 4.9 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal Rieske PF00355.26 PIK43726.1 - 4.5e-13 49.0 0.0 9.8e-13 47.9 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Nop10p PF04135.12 PIK43727.1 - 4.4e-21 74.7 0.3 4.4e-21 74.7 0.3 1.4 2 0 0 2 2 2 1 Nucleolar RNA-binding protein, Nop10p family MIP PF00230.20 PIK43728.1 - 0.0091 15.7 10.1 0.26 10.9 2.8 3.4 1 1 0 2 2 2 2 Major intrinsic protein DASH_Dam1 PF08653.10 PIK43728.1 - 0.11 12.3 0.0 0.3 10.9 0.0 1.8 1 0 0 1 1 1 0 DASH complex subunit Dam1 AA_permease_2 PF13520.6 PIK43730.1 - 4.8e-12 45.4 4.3 5.5e-12 45.2 4.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK43730.1 - 1.1e-06 27.5 5.0 1.7e-06 26.9 5.0 1.4 1 1 0 1 1 1 1 Amino acid permease SirB PF04247.12 PIK43730.1 - 0.0025 17.9 4.6 0.0032 17.5 4.6 1.4 1 0 0 1 1 1 1 Invasion gene expression up-regulator, SirB HSCB_C PF07743.13 PIK43731.1 - 0.13 12.7 0.3 0.31 11.5 0.3 1.6 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain DUF640 PF04852.12 PIK43732.1 - 0.13 12.5 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF640) HEAT PF02985.22 PIK43733.1 - 3.5e-17 61.0 10.2 0.03 14.6 0.2 8.0 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.6 PIK43733.1 - 1.1e-09 38.6 0.0 0.0025 18.2 0.0 5.4 4 2 1 5 5 5 3 HEAT repeats HEAT_EZ PF13513.6 PIK43733.1 - 1.8e-08 34.7 4.5 0.0027 18.2 0.3 5.9 5 2 2 7 7 7 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK43733.1 - 6.3e-06 26.7 0.0 0.0087 16.6 0.0 3.7 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK43733.1 - 4.4e-05 23.6 0.0 1.1 9.3 0.0 4.8 4 2 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 PIK43733.1 - 0.00011 22.4 0.0 11 6.4 0.0 4.6 4 1 0 4 4 4 2 TAF6 C-terminal HEAT repeat domain CLASP_N PF12348.8 PIK43733.1 - 0.0013 18.4 0.0 7.4 6.1 0.0 4.4 4 1 0 4 4 4 1 CLASP N terminal Adaptin_N PF01602.20 PIK43733.1 - 0.091 11.3 0.0 1.8 7.0 0.0 2.9 3 1 0 3 3 3 0 Adaptin N terminal region Plasmodium_HRP PF05403.11 PIK43734.1 - 0.014 15.2 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) BDM PF10684.9 PIK43734.1 - 0.063 13.6 1.8 0.13 12.6 0.2 2.3 1 1 1 2 2 2 0 Putative biofilm-dependent modulation protein PSCyt3 PF07627.11 PIK43734.1 - 0.071 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) Dsh_C PF12316.8 PIK43734.1 - 2.3 8.6 5.6 3.7 7.9 5.6 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal PhnJ PF06007.11 PIK43734.1 - 2.9 6.8 7.1 0.94 8.4 0.9 2.2 1 1 1 2 2 2 0 Phosphonate metabolism protein PhnJ DUF1350 PF07082.11 PIK43734.1 - 7.3 5.8 7.5 20 4.3 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1350) zf-B_box PF00643.24 PIK43735.1 - 0.02 15.0 10.8 0.028 14.5 10.8 1.2 1 0 0 1 1 1 0 B-box zinc finger ACBP PF00887.19 PIK43735.1 - 0.047 13.9 0.6 0.1 12.8 0.6 1.7 1 1 0 1 1 1 0 Acyl CoA binding protein SRP19 PF01922.17 PIK43735.1 - 0.11 13.4 0.0 0.23 12.4 0.0 1.5 1 0 0 1 1 1 0 SRP19 protein FYVE PF01363.21 PIK43736.1 - 6.4e-06 26.2 2.9 9.7e-06 25.6 2.9 1.3 1 0 0 1 1 1 1 FYVE zinc finger DUF4428 PF14471.6 PIK43736.1 - 0.0007 19.5 1.7 0.11 12.5 0.3 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4428) NMD3 PF04981.13 PIK43736.1 - 0.0061 16.1 0.2 0.0065 16.0 0.2 1.1 1 0 0 1 1 1 1 NMD3 family zf-SNAP50_C PF12251.8 PIK43736.1 - 0.054 13.2 1.7 0.88 9.2 0.1 2.1 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal FYVE_2 PF02318.16 PIK43736.1 - 0.14 12.4 2.1 0.28 11.4 2.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_5 PF14634.6 PIK43736.1 - 7.4 6.6 8.4 3.3 7.8 0.2 2.9 2 1 0 2 2 2 0 zinc-RING finger domain Mcl1_mid PF12341.8 PIK43737.1 - 7.7e-91 304.5 0.3 3.2e-90 302.5 0.1 2.1 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 PIK43737.1 - 1.7e-09 38.1 15.2 0.0014 19.4 0.0 6.1 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43737.1 - 3.6e-09 36.8 1.8 2.3e-05 24.6 0.1 5.1 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain HMG_box PF00505.19 PIK43737.1 - 1.4e-07 31.8 2.1 1.4e-07 31.8 2.1 2.5 2 0 0 2 2 2 1 HMG (high mobility group) box Pkinase PF00069.25 PIK43738.1 - 2.4e-24 86.1 0.0 4.7e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43738.1 - 3.4e-09 36.4 0.0 6.2e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 PIK43738.1 - 0.32 9.9 0.2 0.49 9.3 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase 7tm_1 PF00001.21 PIK43739.1 - 3.5e-37 128.2 17.1 4.2e-37 127.9 17.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43739.1 - 8.6e-11 41.7 12.7 1.1e-10 41.3 12.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK43739.1 - 2e-09 37.5 10.7 2e-09 37.5 10.7 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Gaa1 PF04114.14 PIK43739.1 - 1.6 7.7 7.4 0.031 13.3 0.5 1.5 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component TPR_MLP1_2 PF07926.12 PIK43740.1 - 0.0011 19.0 17.2 0.0011 19.0 17.2 8.0 2 1 4 7 7 7 4 TPR/MLP1/MLP2-like protein Synaphin PF05835.12 PIK43741.1 - 2.1e-19 70.2 23.3 2.8e-19 69.8 23.3 1.1 1 0 0 1 1 1 1 Synaphin protein PhageMin_Tail PF10145.9 PIK43742.1 - 0.06 13.2 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 Phage-related minor tail protein Peptidase_M13 PF01431.21 PIK43744.1 - 1.3e-47 162.0 0.5 7.6e-38 130.2 0.0 2.0 1 1 1 2 2 2 2 Peptidase family M13 Peptidase_M13_N PF05649.13 PIK43745.1 - 2.7e-112 376.3 0.2 3.6e-112 375.8 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK43745.1 - 1.7e-69 233.5 0.0 3e-69 232.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 Herpes_UL73 PF03554.13 PIK43745.1 - 0.43 10.6 6.0 0.9 9.6 0.5 2.8 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein RVT_1 PF00078.27 PIK43746.1 - 1.9e-27 96.2 0.1 4.5e-27 95.0 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK43746.1 - 4e-19 68.5 0.0 6.7e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK43746.1 - 3.9e-07 30.3 0.0 7.1e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK43747.1 - 1.3e-23 82.9 0.1 2.5e-23 81.9 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK43747.1 - 2.1e-12 47.3 0.0 3.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK43747.1 - 0.00026 21.1 0.0 0.00068 19.8 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger Copine PF07002.16 PIK43748.1 - 2e-57 194.2 0.0 2.4e-57 193.9 0.0 1.0 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 PIK43748.1 - 1.1e-09 38.7 0.1 1.8e-09 38.0 0.1 1.4 1 1 0 1 1 1 1 vWA found in TerF C terminus Mito_carr PF00153.27 PIK43749.1 - 3.7e-40 135.7 3.2 7.5e-15 54.6 0.1 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein DUF4371 PF14291.6 PIK43751.1 - 7.4e-27 94.5 0.0 1.6e-26 93.4 0.0 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4371) UBM PF14377.6 PIK43751.1 - 0.013 14.9 0.9 0.023 14.1 0.9 1.3 1 0 0 1 1 1 0 Ubiquitin binding region T4BSS_DotI_IcmL PF11393.8 PIK43751.1 - 0.061 12.8 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component rve PF00665.26 PIK43752.1 - 6.4e-09 36.0 0.0 8.3e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 PIK43754.1 - 7.3e-06 25.8 16.1 0.0026 17.8 3.3 3.9 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43754.1 - 3.5e-05 23.5 6.2 0.0023 17.7 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43754.1 - 0.00014 21.5 14.3 0.38 10.5 1.1 3.3 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK43754.1 - 2.2 8.5 14.3 0.47 10.7 7.0 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK43754.1 - 8.7 6.2 11.9 0.7 9.7 0.3 3.2 3 0 0 3 3 3 0 C2H2 zinc-finger DUF5104 PF17117.5 PIK43755.1 - 0.045 14.2 0.1 0.078 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) zf-CCHC PF00098.23 PIK43756.1 - 1.3e-06 28.2 16.2 0.00079 19.4 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43756.1 - 0.00098 18.9 8.2 0.12 12.2 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK43756.1 - 0.0074 16.2 12.8 0.28 11.2 1.2 3.6 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43756.1 - 0.026 14.3 0.2 0.026 14.3 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK43756.1 - 0.027 14.2 0.8 0.027 14.2 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK43756.1 - 0.059 13.1 11.1 5.9 6.7 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle Cys_rich_VLP PF14194.6 PIK43758.1 - 0.35 11.0 3.3 0.58 10.3 2.3 1.8 1 1 1 2 2 2 0 Cysteine-rich VLP HYR PF02494.16 PIK43760.1 - 2.2e-40 136.8 27.2 1.2e-12 48.0 0.5 6.1 5 1 0 5 5 5 5 HYR domain Sushi PF00084.20 PIK43760.1 - 8.8e-28 96.7 66.3 8.7e-07 29.5 3.1 8.5 9 0 0 9 9 9 6 Sushi repeat (SCR repeat) DUF5011 PF16403.5 PIK43760.1 - 0.0022 18.1 0.6 1.9 8.7 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF5011) Big_3_2 PF12245.8 PIK43760.1 - 0.0053 17.0 0.7 3.2 8.0 0.0 4.0 4 0 0 4 4 4 1 Bacterial Ig-like domain Big_3_4 PF13754.6 PIK43760.1 - 0.013 15.2 0.0 30 4.4 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function DUF4625 PF15418.6 PIK43760.1 - 0.014 15.6 0.0 13 6.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4625) SusE PF14292.6 PIK43760.1 - 0.034 14.4 1.0 0.1 12.9 1.0 1.8 1 0 0 1 1 1 0 SusE outer membrane protein FlgD_ig PF13860.6 PIK43760.1 - 0.13 12.2 0.5 23 5.0 0.0 3.5 3 0 0 3 3 3 0 FlgD Ig-like domain Big_5 PF13205.6 PIK43760.1 - 3.6 8.3 5.4 19 6.0 0.4 3.5 3 0 0 3 3 3 0 Bacterial Ig-like domain EGF PF00008.27 PIK43761.1 - 1e-35 121.6 96.6 1.4e-07 31.7 8.4 8.0 8 0 0 8 8 8 6 EGF-like domain Ephrin_rec_like PF07699.13 PIK43761.1 - 2.3e-18 65.6 10.1 1.7e-11 43.7 2.0 4.0 2 0 0 2 2 2 2 Putative ephrin-receptor like hEGF PF12661.7 PIK43761.1 - 1.4e-12 47.7 84.9 0.00045 20.8 6.2 9.0 9 1 0 9 9 9 6 Human growth factor-like EGF EGF_2 PF07974.13 PIK43761.1 - 6.4e-06 26.4 106.6 0.013 15.8 10.7 8.0 8 1 0 8 8 8 5 EGF-like domain EGF_3 PF12947.7 PIK43761.1 - 7.6e-05 22.8 80.8 0.038 14.2 5.7 7.7 4 2 3 7 7 7 6 EGF domain EGF PF00008.27 PIK43762.1 - 1.2e-21 76.6 31.3 3.4e-07 30.5 3.9 4.6 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK43762.1 - 4.5e-11 42.9 27.6 0.00047 20.7 1.9 5.2 4 0 0 4 4 4 4 Human growth factor-like EGF EGF_CA PF07645.15 PIK43762.1 - 0.00039 20.6 38.2 0.0065 16.7 5.4 4.9 3 1 2 5 5 5 4 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK43762.1 - 2.7 8.4 36.0 2.3 8.6 2.7 4.2 3 1 1 4 4 4 0 Coagulation Factor Xa inhibitory site EamA PF00892.20 PIK43763.1 - 7e-24 84.5 37.1 1.8e-14 54.0 12.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family zf_Rg PF17915.1 PIK43763.1 - 0.042 13.3 0.4 0.079 12.4 0.4 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger YibE_F PF07907.11 PIK43763.1 - 0.73 9.3 29.8 0.16 11.4 5.4 3.1 3 0 0 3 3 3 0 YibE/F-like protein 7tm_1 PF00001.21 PIK43764.1 - 1.8e-19 70.1 5.0 2.2e-19 69.8 5.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK43764.1 - 1.7e-08 34.4 7.7 1.8e-08 34.3 7.7 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK43764.1 - 0.00096 18.6 4.7 0.0014 18.0 4.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx HlyIII PF03006.20 PIK43764.1 - 0.27 10.9 6.8 0.17 11.6 1.2 2.1 1 1 1 2 2 2 0 Haemolysin-III related Myco_arth_vir_N PF09610.10 PIK43764.1 - 7.4 6.8 11.7 0.9 9.7 1.9 3.0 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimerisation PF08100.11 PIK43765.1 - 9.5e-06 25.5 0.0 3.9 7.6 0.0 4.8 4 1 1 5 5 5 2 Dimerisation domain DUF2682 PF10909.8 PIK43765.1 - 0.0032 17.9 6.3 17 6.0 0.1 5.2 3 2 3 6 6 6 1 Protein of unknown function (DUF2682) GPAT_N PF14829.6 PIK43765.1 - 0.01 15.8 0.0 14 5.8 0.0 3.4 2 1 0 3 3 3 0 Glycerol-3-phosphate acyltransferase N-terminal RecR PF02132.15 PIK43765.1 - 0.014 15.0 3.5 25 4.5 0.0 4.8 4 1 1 5 5 5 0 RecR protein NifU_N PF01592.16 PIK43765.1 - 0.036 14.2 0.2 15 5.8 0.0 2.9 2 1 1 3 3 3 0 NifU-like N terminal domain QslA_E PF18226.1 PIK43765.1 - 0.055 13.4 1.8 1.7 8.6 0.2 2.5 1 1 1 2 2 2 0 LasR-specific antiactivator QslA chain E FAA_hydro_N_2 PF18288.1 PIK43765.1 - 0.12 12.8 0.5 12 6.3 0.0 3.2 2 1 1 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 DUF1571 PF07608.11 PIK43765.1 - 2.7 7.4 8.1 0.55 9.6 3.4 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1571) LEAP-2 PF07359.11 PIK43766.1 - 0.084 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Pkinase PF00069.25 PIK43767.1 - 1.7e-59 201.4 0.0 2.1e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43767.1 - 2.2e-36 125.5 0.0 2.7e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK43767.1 - 0.0003 19.7 0.0 0.00043 19.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK43767.1 - 0.00072 19.0 0.0 0.0015 18.0 0.0 1.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK43767.1 - 0.0013 18.8 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK43767.1 - 0.025 13.5 0.1 0.058 12.3 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 PIK43767.1 - 0.028 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 PIK43768.1 - 1.6e-15 56.7 0.1 2.6e-15 56.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-synt_G PF04718.15 PIK43769.1 - 2e-22 79.9 0.0 5e-22 78.6 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit MATH PF00917.26 PIK43770.1 - 0.023 14.9 0.5 1.9 8.7 0.0 2.9 1 1 1 2 2 2 0 MATH domain DUF4200 PF13863.6 PIK43770.1 - 0.042 14.2 1.6 0.082 13.3 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) FUSC PF04632.12 PIK43770.1 - 0.14 10.6 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Kinesin PF00225.23 PIK43771.1 - 2.1e-108 362.2 1.2 2.1e-108 362.2 1.2 2.1 2 0 0 2 2 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK43771.1 - 5.6e-60 201.6 6.9 1.9e-55 186.9 0.0 3.5 3 0 0 3 3 3 3 Microtubule binding KASH_CCD PF14662.6 PIK43771.1 - 7e-06 26.0 44.7 0.00035 20.5 15.3 3.8 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH Myosin_tail_1 PF01576.19 PIK43771.1 - 9.6e-06 23.7 37.1 1.5e-05 23.1 37.1 1.2 1 0 0 1 1 1 1 Myosin tail BST2 PF16716.5 PIK43771.1 - 0.00029 21.4 21.4 0.0026 18.3 5.6 5.3 4 2 2 6 6 5 3 Bone marrow stromal antigen 2 MPS2 PF17060.5 PIK43771.1 - 0.00045 19.6 30.4 0.028 13.7 14.1 3.5 2 1 2 4 4 4 2 Monopolar spindle protein 2 AAA_13 PF13166.6 PIK43771.1 - 0.018 13.7 29.2 0.013 14.1 27.3 1.8 2 0 0 2 2 2 0 AAA domain BRE1 PF08647.11 PIK43771.1 - 0.019 15.0 43.8 0.14 12.3 4.1 5.2 2 1 3 5 5 5 0 BRE1 E3 ubiquitin ligase MAD PF05557.13 PIK43771.1 - 0.044 12.2 41.8 0.054 11.8 11.9 2.9 1 1 2 3 3 3 0 Mitotic checkpoint protein ATG16 PF08614.11 PIK43771.1 - 0.045 14.0 45.2 2.1 8.5 6.8 3.4 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Filament PF00038.21 PIK43771.1 - 0.055 13.1 38.9 0.14 11.7 38.1 1.9 1 1 1 2 2 2 0 Intermediate filament protein Atg14 PF10186.9 PIK43771.1 - 0.073 12.1 32.7 0.11 11.6 8.5 3.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 PIK43771.1 - 0.091 11.6 40.1 0.29 10.0 21.1 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 PIK43771.1 - 0.14 12.6 40.4 1.2 9.6 22.2 3.0 1 1 2 3 3 3 0 Fez1 DNAPolymera_Pol PF11590.8 PIK43771.1 - 0.15 11.9 3.9 0.49 10.3 0.3 3.0 3 0 0 3 3 3 0 DNA polymerase catalytic subunit Pol DUF4407 PF14362.6 PIK43771.1 - 0.19 11.0 24.2 0.46 9.8 10.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YtxH PF12732.7 PIK43771.1 - 0.35 11.4 10.8 3.5 8.2 0.6 4.6 1 1 3 4 4 4 0 YtxH-like protein Laminin_II PF06009.12 PIK43771.1 - 0.47 10.5 27.5 0.26 11.3 9.2 3.9 1 1 2 3 3 3 0 Laminin Domain II Bacillus_HBL PF05791.11 PIK43771.1 - 0.53 10.1 16.9 4 7.2 3.6 3.5 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) YusW PF14039.6 PIK43771.1 - 0.61 10.6 18.3 0.39 11.2 4.5 3.9 1 1 3 4 4 4 0 YusW-like protein Lebercilin PF15619.6 PIK43771.1 - 2.6 7.7 44.6 11 5.7 24.5 3.6 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Baculo_PEP_C PF04513.12 PIK43771.1 - 3.3 7.8 19.4 1.1 9.3 5.1 3.9 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HU-CCDC81_bac_2 PF18175.1 PIK43771.1 - 4.9 7.1 15.3 3 7.8 0.4 4.7 4 2 2 6 6 5 0 CCDC81-like prokaryotic HU domain 2 Goodbye PF17109.5 PIK43771.1 - 8.1 6.9 11.7 20 5.7 0.8 3.8 1 1 2 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF1664 PF07889.12 PIK43771.1 - 8.3 6.5 32.3 0.79 9.8 7.3 4.3 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 PIK43771.1 - 8.3 5.5 22.1 2.4 7.3 10.0 2.5 1 1 1 2 2 2 0 TMPIT-like protein zf-NOSIP PF15906.5 PIK43772.1 - 6.2e-39 132.0 0.5 1.5e-38 130.8 0.5 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 PIK43772.1 - 3.2e-09 36.8 0.2 0.0029 17.8 0.0 3.1 3 0 0 3 3 3 2 U-box domain Rtf2 PF04641.12 PIK43772.1 - 2.4e-08 33.7 2.4 2.1e-05 24.0 0.4 3.1 2 1 1 3 3 3 2 Rtf2 RING-finger zf-Nse PF11789.8 PIK43772.1 - 0.0026 17.6 0.2 0.042 13.7 0.1 3.0 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit INCA1 PF15142.6 PIK43772.1 - 0.023 14.7 0.4 0.037 14.1 0.4 1.3 1 0 0 1 1 1 0 INCA1 Phage_Gp23 PF10669.9 PIK43772.1 - 0.037 14.4 4.2 0.065 13.6 4.2 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) EVE PF01878.18 PIK43773.1 - 1.8e-49 167.5 0.2 2.3e-49 167.1 0.2 1.2 1 0 0 1 1 1 1 EVE domain HORMA PF02301.18 PIK43774.1 - 3.1e-39 134.8 0.1 3.1e-39 134.8 0.1 3.9 3 2 0 3 3 3 1 HORMA domain PHD PF00628.29 PIK43774.1 - 1.1e-06 28.4 8.6 2.9e-06 27.1 8.6 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK43774.1 - 0.0025 17.3 3.5 0.0048 16.4 3.5 1.5 1 0 0 1 1 1 1 PHD-finger Tetraspanin PF00335.20 PIK43775.1 - 7.9e-33 114.1 13.7 1.4e-32 113.3 13.7 1.4 1 1 0 1 1 1 1 Tetraspanin family SCIMP PF15050.6 PIK43775.1 - 0.44 11.0 0.1 0.44 11.0 0.1 1.8 2 0 0 2 2 2 0 SCIMP protein DUF2556 PF10831.8 PIK43776.1 - 0.0091 15.9 1.2 21 5.2 0.1 3.4 4 0 0 4 4 4 2 Protein of unknown function (DUF2556) Thyroglob_assoc PF16597.5 PIK43776.1 - 0.7 10.2 11.4 10 6.5 0.4 4.4 2 2 1 3 3 3 0 Thyroglobulin_1 repeat associated disordered domain RHIM PF12721.7 PIK43776.1 - 3.9 8.0 6.7 20 5.7 0.9 4.1 1 1 2 3 3 3 0 RIP homotypic interaction motif Thyroglob_assoc PF16597.5 PIK43777.1 - 1.1 9.7 12.8 18 5.8 0.2 4.7 3 1 2 5 5 5 0 Thyroglobulin_1 repeat associated disordered domain zf-CCHC PF00098.23 PIK43781.1 - 1.9e-05 24.5 16.1 0.0031 17.5 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43781.1 - 5.9e-05 22.8 6.2 0.0028 17.4 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43781.1 - 0.0002 21.0 14.2 0.44 10.3 1.0 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK43781.1 - 1.6 9.0 12.4 0.54 10.5 6.9 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK43781.1 - 5 7.0 12.9 0.86 9.4 0.3 3.9 4 0 0 4 4 4 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK43783.1 - 0.00047 19.8 15.0 0.39 10.5 1.1 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 PIK43783.1 - 0.0026 17.8 3.3 0.0026 17.8 3.3 4.1 4 0 0 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43783.1 - 0.0053 16.6 8.4 0.11 12.3 0.7 2.8 2 0 0 2 2 2 2 Zinc knuckle IBR PF01485.21 PIK43783.1 - 1.1 9.6 12.4 0.45 10.8 6.9 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK43783.1 - 1.9 8.3 12.5 0.69 9.7 0.2 4.1 4 0 0 4 4 4 0 C2H2 zinc-finger Peptidase_A17 PF05380.13 PIK43784.1 - 2.7e-17 63.3 1.3 3.8e-17 62.8 0.0 1.9 2 0 0 2 2 2 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK43784.1 - 1.2e-05 25.4 0.8 1.2e-05 25.4 0.8 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain Tis11B_N PF04553.12 PIK43785.1 - 0.041 14.4 0.1 0.064 13.8 0.1 1.2 1 0 0 1 1 1 0 Tis11B like protein, N terminus Peptidase_U57 PF05582.12 PIK43785.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 YabG peptidase U57 HECT PF00632.25 PIK43786.1 - 1.4e-16 60.9 0.0 1.5e-15 57.5 0.0 2.2 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF1456 PF07308.13 PIK43787.1 - 0.079 13.3 0.1 14 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) RWP-RK PF02042.15 PIK43787.1 - 0.4 10.7 0.2 0.4 10.7 0.2 2.0 2 0 0 2 2 2 0 RWP-RK domain HHH_6 PF14579.6 PIK43788.1 - 0.13 12.5 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif zf-CCHC PF00098.23 PIK43790.1 - 4.6e-09 35.9 9.1 0.00041 20.3 0.2 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK43790.1 - 0.00023 20.9 7.8 0.064 13.1 3.5 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK43790.1 - 0.0029 17.3 11.1 1.3 8.8 0.3 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK43790.1 - 0.0046 16.9 12.8 0.22 11.5 1.7 3.2 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43790.1 - 0.014 15.2 0.2 0.014 15.2 0.2 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK43790.1 - 0.014 15.1 0.8 0.014 15.1 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger RVT_1 PF00078.27 PIK43792.1 - 7.5e-15 55.0 0.0 5.8e-07 29.3 0.0 3.1 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK43792.1 - 7.5e-06 26.6 0.5 1.9e-05 25.3 0.5 1.7 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase LRV_FeS PF05484.11 PIK43793.1 - 8.9 6.4 9.0 2.1 8.4 0.6 2.8 3 0 0 3 3 3 0 LRV protein FeS4 cluster HSR PF03172.13 PIK43794.1 - 0.076 13.2 0.0 0.87 9.8 0.0 2.3 2 1 0 2 2 2 0 HSR domain SMK-1 PF04802.15 PIK43795.1 - 0.056 13.3 0.0 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 zf-CCHC PF00098.23 PIK43796.1 - 0.0024 17.9 0.6 0.0072 16.4 0.6 1.9 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.27 PIK43797.1 - 3.6e-05 23.4 0.0 5.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Carbam_trans_C PF16861.5 PIK43797.1 - 0.088 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus RVT_1 PF00078.27 PIK43798.1 - 3.4e-30 105.2 0.1 4.3e-30 104.9 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TCR PF03638.15 PIK43800.1 - 6.7 7.1 25.4 52 4.3 25.1 2.4 1 1 1 2 2 2 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Exo_endo_phos PF03372.23 PIK43803.1 - 0.00061 19.4 0.0 0.00065 19.3 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF553 PF04473.12 PIK43804.1 - 0.17 11.4 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain DUF553 PF04473.12 PIK43805.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain Milton PF12448.8 PIK43806.1 - 5.4e-06 26.6 3.4 5.4e-06 26.6 3.4 4.7 3 3 1 4 4 4 1 Kinesin associated protein HAP1_N PF04849.13 PIK43807.1 - 1.8e-91 306.6 37.0 2.2e-91 306.3 37.0 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region YabA PF06156.13 PIK43807.1 - 0.12 13.0 30.6 0.86 10.3 2.0 4.0 2 1 1 3 3 3 0 Initiation control protein YabA DUF1615 PF07759.12 PIK43807.1 - 0.14 11.3 3.8 0.22 10.7 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) GIT_CC PF16559.5 PIK43807.1 - 0.16 11.8 0.1 0.16 11.8 0.1 5.1 5 1 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor ATG16 PF08614.11 PIK43807.1 - 0.29 11.3 34.0 2.5 8.3 1.5 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK43807.1 - 0.39 11.1 31.9 0.9 10.0 24.0 2.3 1 1 1 2 2 2 0 Fez1 Leu_zip PF15294.6 PIK43807.1 - 0.59 9.6 33.2 0.59 9.6 3.7 3.1 1 1 0 2 2 2 0 Leucine zipper BLOC1_2 PF10046.9 PIK43807.1 - 0.72 10.2 30.3 0.61 10.4 5.1 4.1 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_TATA_bd PF12325.8 PIK43807.1 - 0.9 9.8 37.7 0.25 11.6 14.8 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding PspB PF06667.12 PIK43807.1 - 3.9 7.6 7.2 0.63 10.1 0.3 3.1 3 1 1 4 4 4 0 Phage shock protein B HMMR_N PF15905.5 PIK43807.1 - 4.2 6.8 36.5 1.7 8.1 4.7 2.2 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal FUSC PF04632.12 PIK43807.1 - 4.4 5.7 4.6 7.6 4.9 4.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family XPG_I PF00867.18 PIK43808.1 - 1e-23 83.5 0.0 2.2e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 PIK43808.1 - 7.6e-08 32.8 0.0 2.1e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 PIK43808.1 - 0.00059 19.4 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing Pkinase PF00069.25 PIK43809.1 - 2.4e-12 46.8 0.0 1.4e-11 44.3 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43809.1 - 0.00012 21.5 0.0 0.0003 20.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase SLS PF14611.6 PIK43809.1 - 0.021 14.6 0.8 0.046 13.6 0.0 1.9 3 0 0 3 3 3 0 Mitochondrial inner-membrane-bound regulator Kdo PF06293.14 PIK43809.1 - 0.076 12.4 0.1 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK43809.1 - 0.12 12.3 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SNARE PF05739.19 PIK43810.1 - 0.013 15.4 0.4 0.038 14.0 0.4 1.8 1 0 0 1 1 1 0 SNARE domain Laminin_II PF06009.12 PIK43810.1 - 0.031 14.3 1.9 0.031 14.3 1.9 2.5 2 1 0 2 2 2 0 Laminin Domain II RseC_MucC PF04246.12 PIK43810.1 - 0.068 13.1 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC TMPIT PF07851.13 PIK43810.1 - 0.17 11.1 7.8 0.1 11.8 2.0 2.2 2 0 0 2 2 2 0 TMPIT-like protein SQHop_cyclase_N PF13249.6 PIK43810.1 - 0.27 10.3 1.7 1.5 7.9 0.1 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain DUF4349 PF14257.6 PIK43810.1 - 0.27 10.6 5.4 0.66 9.4 5.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF1664 PF07889.12 PIK43810.1 - 0.46 10.5 9.0 0.24 11.4 2.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 PIK43810.1 - 0.77 10.1 5.7 0.85 9.9 2.9 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PEP-utilisers_N PF05524.13 PIK43810.1 - 0.82 9.9 9.3 0.062 13.5 2.2 2.4 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal Miga PF10265.9 PIK43810.1 - 0.91 8.4 6.6 0.47 9.4 3.5 1.8 2 1 0 2 2 2 0 Mitoguardin Gly-zipper_Omp PF13488.6 PIK43810.1 - 1.4 9.0 14.9 10 6.2 15.1 2.0 1 1 0 1 1 1 0 Glycine zipper DUF3450 PF11932.8 PIK43810.1 - 2.5 7.4 11.7 0.34 10.2 4.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Rx_N PF18052.1 PIK43810.1 - 2.5 8.4 9.2 0.51 10.7 3.8 2.7 2 1 0 2 2 2 0 Rx N-terminal domain Glyco_transf_18 PF15024.6 PIK43811.1 - 6.4e-229 761.2 0.1 7.3e-229 761.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 18 DUF4525 PF15027.6 PIK43811.1 - 0.0018 18.0 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) TSP_1 PF00090.19 PIK43813.1 - 3.1e-24 84.9 50.2 7.4e-06 26.1 1.5 6.5 5 1 1 6 6 6 6 Thrombospondin type 1 domain MFS_MOT1 PF16983.5 PIK43813.1 - 4.4 7.8 6.5 11 6.5 0.7 2.4 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily RVT_1 PF00078.27 PIK43814.1 - 9e-19 67.9 0.1 1.9e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ADAM_spacer1 PF05986.14 PIK43814.1 - 7e-08 32.5 0.0 1.7e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 PIK43815.1 - 1.5e-09 37.9 5.5 1.5e-09 37.9 5.5 2.4 3 0 0 3 3 3 1 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 PIK43815.1 - 7.2e-06 26.4 2.9 7.2e-06 26.4 2.9 3.0 4 0 0 4 4 4 1 ADAM cysteine-rich domain DHR-2 PF06920.13 PIK43816.1 - 5.9e-31 107.7 0.3 6.5e-31 107.6 0.3 1.0 1 0 0 1 1 1 1 Dock homology region 2 HHH_7 PF14635.6 PIK43816.1 - 0.037 14.4 0.1 0.078 13.3 0.0 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif Pkinase PF00069.25 PIK43817.1 - 7.5e-28 97.6 0.0 1.2e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43817.1 - 6.9e-27 94.4 0.0 1.1e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kunitz_BPTI PF00014.23 PIK43817.1 - 2.3e-16 59.8 12.7 2.3e-16 59.8 12.7 2.6 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Pkinase_fungal PF17667.1 PIK43817.1 - 0.0016 17.3 0.0 0.0025 16.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK43817.1 - 0.007 16.3 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Activin_recp PF01064.23 PIK43817.1 - 2 9.6 28.9 0.18 12.9 16.6 3.5 2 1 1 3 3 3 0 Activin types I and II receptor domain LRR_8 PF13855.6 PIK43818.1 - 2.3e-20 72.1 4.0 1.5e-09 37.4 3.1 3.1 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK43818.1 - 1e-18 67.1 23.6 1.5e-07 31.6 2.3 3.8 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK43818.1 - 1.2e-06 28.3 6.1 1.2 9.9 0.3 5.0 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK43818.1 - 5.6e-06 26.0 11.3 0.56 10.4 0.3 5.2 5 0 0 5 5 5 3 Leucine Rich repeat Beta_helix PF13229.6 PIK43818.1 - 0.058 13.2 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Right handed beta helix region WD40 PF00400.32 PIK43819.1 - 7.1e-11 42.5 5.1 1.4e-05 25.8 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat PQQ_3 PF13570.6 PIK43819.1 - 0.00026 21.4 0.0 0.05 14.1 0.0 2.4 2 0 0 2 2 2 1 PQQ-like domain FAM76 PF16046.5 PIK43819.1 - 0.021 14.2 13.7 0.028 13.8 13.7 1.1 1 0 0 1 1 1 0 FAM76 protein CCDC71L PF15374.6 PIK43819.1 - 0.031 13.6 7.3 0.031 13.6 7.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DDHD PF02862.17 PIK43819.1 - 0.082 13.1 3.9 0.1 12.7 3.9 1.3 1 0 0 1 1 1 0 DDHD domain LptF_LptG PF03739.14 PIK43819.1 - 0.25 10.1 0.7 0.29 9.9 0.7 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG NARP1 PF12569.8 PIK43819.1 - 0.36 9.7 20.6 0.5 9.2 20.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 PIK43819.1 - 0.36 9.0 23.4 0.5 8.6 23.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Gti1_Pac2 PF09729.9 PIK43819.1 - 0.37 10.9 11.7 0.57 10.2 11.7 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Neur_chan_memb PF02932.16 PIK43819.1 - 0.45 10.5 5.4 0.47 10.5 5.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cwf_Cwc_15 PF04889.12 PIK43819.1 - 0.48 10.1 31.5 0.6 9.8 31.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein LRIF1 PF15741.5 PIK43819.1 - 0.57 8.6 14.6 0.66 8.4 14.6 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 AP-5_subunit_s1 PF15001.6 PIK43819.1 - 0.64 10.0 6.5 0.95 9.4 6.5 1.5 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Cellulose_synt PF03552.14 PIK43819.1 - 0.74 8.2 3.9 0.83 8.1 3.9 1.2 1 0 0 1 1 1 0 Cellulose synthase EOS1 PF12326.8 PIK43819.1 - 0.89 9.5 3.6 1.2 9.1 3.6 1.4 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.17 PIK43819.1 - 1.5 7.5 16.0 1.8 7.2 16.0 1.1 1 0 0 1 1 1 0 Presenilin Rtf2 PF04641.12 PIK43819.1 - 1.5 8.1 21.1 2 7.7 21.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SprA-related PF12118.8 PIK43819.1 - 1.8 7.6 16.3 2.3 7.2 16.3 1.2 1 0 0 1 1 1 0 SprA-related family Hid1 PF12722.7 PIK43819.1 - 2.1 6.3 11.1 2.3 6.2 11.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FGF-BP1 PF06473.12 PIK43819.1 - 2.3 8.0 18.5 3.3 7.5 18.5 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) TMEM214 PF10151.9 PIK43819.1 - 3.7 5.9 14.3 4.7 5.6 14.3 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Thioredoxin_6 PF13848.6 PIK43820.1 - 5.4e-36 124.2 0.2 4.5e-30 104.9 0.1 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 PIK43820.1 - 1.2e-22 79.9 0.0 2.8e-22 78.7 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 PIK43820.1 - 5e-06 26.6 0.0 0.02 15.1 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK43820.1 - 3.9e-05 24.1 0.1 9e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK43820.1 - 0.0024 18.2 0.1 0.0076 16.6 0.1 1.9 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 PIK43820.1 - 0.0033 16.8 0.2 0.0049 16.3 0.2 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 PIK43820.1 - 0.0042 16.2 0.0 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 Calsequestrin HyaE PF07449.11 PIK43820.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TPR_2 PF07719.17 PIK43821.1 - 1e-24 84.6 15.1 1.5e-06 27.8 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43821.1 - 2.4e-20 72.6 11.5 7.1e-11 42.2 0.7 5.4 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK43821.1 - 3e-19 67.9 17.6 7e-07 28.8 0.0 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat PLAT PF01477.23 PIK43821.1 - 7.7e-19 68.4 0.1 2.1e-18 67.0 0.1 1.8 1 0 0 1 1 1 1 PLAT/LH2 domain TPR_8 PF13181.6 PIK43821.1 - 1.9e-15 55.7 15.8 3.3e-05 23.7 0.0 7.3 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43821.1 - 3.2e-14 51.8 6.3 0.0051 16.7 0.0 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43821.1 - 1.1e-12 48.4 7.8 4.4e-06 27.2 0.0 5.8 5 1 1 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43821.1 - 2e-12 47.1 4.8 0.0013 18.9 0.2 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK43821.1 - 5.3e-12 45.2 0.5 3.5e-07 29.8 0.0 4.7 3 1 0 4 4 4 1 TPR repeat TPR_19 PF14559.6 PIK43821.1 - 1.5e-09 38.2 11.3 0.00058 20.3 0.0 5.1 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK43821.1 - 2.7e-07 30.3 2.6 6.9e-05 22.4 3.2 3.0 2 2 1 3 3 3 1 MalT-like TPR region TPR_14 PF13428.6 PIK43821.1 - 2.8e-07 30.8 9.3 0.61 11.0 0.0 6.3 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43821.1 - 5.1e-06 26.5 0.9 0.18 12.2 0.1 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43821.1 - 1.8e-05 25.1 8.1 2.6 8.9 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43821.1 - 9.6e-05 22.5 1.9 1.2 9.3 0.1 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK43821.1 - 0.00013 21.7 6.9 9.8 6.2 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF2225 PF09986.9 PIK43821.1 - 0.001 18.8 2.9 0.0037 17.0 0.1 2.7 3 0 0 3 3 2 1 Uncharacterized protein conserved in bacteria (DUF2225) Fis1_TPR_C PF14853.6 PIK43821.1 - 0.0023 18.0 1.0 0.12 12.5 0.0 3.9 3 1 2 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 PIK43821.1 - 0.019 15.4 4.5 0.23 11.9 0.1 3.6 3 1 1 4 4 4 0 Bacterial transcriptional activator domain SMBP PF16785.5 PIK43821.1 - 0.059 13.6 6.5 0.45 10.8 0.3 3.6 3 0 0 3 3 3 0 Small metal-binding protein TPR_3 PF07720.12 PIK43821.1 - 0.068 13.2 2.0 26 5.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DDE_Tnp_1_3 PF13612.6 PIK43821.1 - 0.081 12.9 0.6 0.32 11.0 0.2 2.1 2 0 0 2 2 2 0 Transposase DDE domain FUSC PF04632.12 PIK43821.1 - 0.25 9.9 1.6 4.3 5.7 0.1 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family RNA_pol_Rpc4 PF05132.14 PIK43821.1 - 0.75 10.2 24.0 0.11 12.9 0.9 3.9 3 0 0 3 3 3 0 RNA polymerase III RPC4 MIT PF04212.18 PIK43821.1 - 0.78 9.9 6.4 4.7 7.4 0.2 4.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 PIK43821.1 - 0.84 9.3 10.2 0.53 10.0 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain CUB PF00431.20 PIK43822.1 - 2.8e-65 217.5 3.6 2.3e-32 111.6 0.2 2.2 2 0 0 2 2 2 2 CUB domain Peptidase_S8 PF00082.22 PIK43822.1 - 6.4e-23 81.4 4.3 6.4e-23 81.4 4.3 1.7 2 0 0 2 2 2 1 Subtilase family CUB_2 PF02408.20 PIK43822.1 - 4.9e-05 23.1 1.4 0.0024 17.6 0.5 2.5 2 0 0 2 2 2 2 CUB-like domain Inhibitor_I9 PF05922.16 PIK43823.1 - 1.2e-09 38.7 0.3 2.9e-09 37.5 0.3 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 PIK43823.1 - 1.1e-08 34.7 4.8 3.9e-08 32.9 4.8 1.7 1 1 0 1 1 1 1 Subtilase family AdoMet_MTase PF07757.13 PIK43823.1 - 0.025 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase WD40 PF00400.32 PIK43824.1 - 5e-23 80.9 18.7 1.7e-05 25.5 1.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43824.1 - 1.5e-13 50.8 0.0 0.0088 16.3 0.0 5.4 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 PIK43824.1 - 8.8e-06 25.5 2.6 0.089 12.8 0.5 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 PIK43824.1 - 0.00028 20.1 0.1 0.0016 17.6 0.0 2.2 2 1 2 4 4 4 1 Coatomer WD associated region eIF2A PF08662.11 PIK43824.1 - 0.00037 20.4 0.2 1.3 8.8 0.1 3.5 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK43824.1 - 0.001 18.1 0.1 0.41 9.6 0.0 2.8 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hormone_recep PF00104.30 PIK43825.1 - 3.5e-14 52.9 1.2 1.2e-13 51.2 1.1 1.9 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor rve PF00665.26 PIK43826.1 - 4.2e-16 59.2 0.3 8.8e-16 58.2 0.3 1.5 1 0 0 1 1 1 1 Integrase core domain RBD PF02196.15 PIK43827.1 - 9.3e-25 86.5 0.0 2.5e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 PIK43827.1 - 3.8e-08 33.1 7.3 7.7e-08 32.1 7.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3452 PF11934.8 PIK43827.1 - 0.11 12.0 1.0 0.45 10.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) zf-RING-like PF08746.11 PIK43827.1 - 0.13 12.5 4.6 0.32 11.3 4.6 1.6 1 0 0 1 1 1 0 RING-like domain Adaptin_binding PF10199.9 PIK43827.1 - 0.25 11.9 3.7 7.9 7.1 0.1 3.1 2 1 1 3 3 3 0 Alpha and gamma adaptin binding protein p34 DUF1258 PF06869.12 PIK43827.1 - 0.29 10.6 2.4 0.49 9.8 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) C1_2 PF03107.16 PIK43827.1 - 1.6 9.1 7.2 3.5 8.0 5.9 2.3 2 0 0 2 2 2 0 C1 domain Pkinase_Tyr PF07714.17 PIK43828.1 - 4.6e-60 203.1 0.0 6e-60 202.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43828.1 - 6.1e-57 193.0 0.0 7.8e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK43828.1 - 8.5e-08 31.8 0.0 1.2e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK43828.1 - 0.00075 18.4 0.6 0.0016 17.3 0.6 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK43828.1 - 0.019 14.3 0.1 0.033 13.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK43828.1 - 0.052 13.5 0.1 0.76 9.7 0.1 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family Peptidase_M76 PF09768.9 PIK43829.1 - 2.6e-53 180.3 6.2 3.1e-53 180.0 6.2 1.1 1 0 0 1 1 1 1 Peptidase M76 family wnt PF00110.19 PIK43830.1 - 7.1e-47 160.5 0.2 8.2e-47 160.3 0.2 1.0 1 0 0 1 1 1 1 wnt family DUF4785 PF16024.5 PIK43830.1 - 0.1 11.4 0.0 0.12 11.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4785) DUF2264 PF10022.9 PIK43830.1 - 0.21 10.7 0.0 0.25 10.4 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) wnt PF00110.19 PIK43831.1 - 4.5e-60 203.8 23.7 5.2e-60 203.6 23.7 1.0 1 0 0 1 1 1 1 wnt family ST7 PF04184.12 PIK43832.1 - 1.3e-274 911.7 3.4 2.1e-274 911.0 3.4 1.3 1 1 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 PIK43832.1 - 0.00013 22.4 0.2 0.0014 19.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43832.1 - 0.00096 19.8 1.1 0.29 12.0 0.0 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43832.1 - 0.069 13.3 0.0 2.1 8.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4227 PF14004.6 PIK43832.1 - 0.08 12.9 0.3 0.43 10.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) TPR_19 PF14559.6 PIK43832.1 - 0.081 13.5 0.5 1.4 9.5 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat Clathrin PF00637.20 PIK43832.1 - 0.1 12.5 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS 5_3_exonuc_N PF02739.16 PIK43837.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HCV_NS4b PF01001.19 PIK43837.1 - 0.19 11.3 0.0 0.43 10.1 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4b MAPEG PF01124.18 PIK43838.1 - 2e-09 37.5 0.0 2.3e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 MAPEG family Ig_3 PF13927.6 PIK43839.1 - 2.9e-05 24.6 6.7 0.00011 22.7 2.6 3.6 3 1 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK43839.1 - 7.2e-05 22.9 3.2 7.2e-05 22.9 3.2 3.0 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK43839.1 - 0.00032 20.7 0.3 0.48 10.5 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK43839.1 - 0.018 15.2 1.4 0.34 11.1 1.6 2.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain YL1 PF05764.13 PIK43840.1 - 0.013 15.6 4.3 0.013 15.6 4.3 1.9 2 0 0 2 2 2 0 YL1 nuclear protein DUF3290 PF11694.8 PIK43840.1 - 0.49 10.4 1.6 0.81 9.6 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) GAPT PF11770.8 PIK43840.1 - 0.83 9.5 5.2 1.1 9.2 1.3 2.6 2 1 0 2 2 2 0 GRB2-binding adapter (GAPT) Ig_3 PF13927.6 PIK43841.1 - 1.2e-10 41.8 1.1 7.4e-10 39.3 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK43841.1 - 8.3e-08 32.2 0.0 2.5e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK43841.1 - 0.014 15.6 0.1 0.11 12.7 0.1 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK43842.1 - 4.6e-09 36.7 5.1 2.9e-05 24.6 0.0 4.0 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK43842.1 - 1.3e-08 34.8 0.0 0.0028 17.7 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain SID-1_RNA_chan PF13965.6 PIK43842.1 - 0.00085 17.9 0.1 0.0012 17.4 0.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Ig_2 PF13895.6 PIK43842.1 - 0.0049 17.2 3.5 15 6.0 0.1 3.5 3 0 0 3 3 3 0 Immunoglobulin domain Orf78 PF06024.12 PIK43842.1 - 0.0061 16.8 2.5 0.0094 16.2 0.0 2.3 2 0 0 2 2 2 1 Orf78 (ac78) TMEM154 PF15102.6 PIK43842.1 - 0.0088 16.0 2.1 0.0088 16.0 2.1 2.0 2 0 0 2 2 2 1 TMEM154 protein family DUF5383 PF17355.2 PIK43842.1 - 0.045 14.1 1.1 0.045 14.1 1.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5383) DUF5305 PF17231.2 PIK43842.1 - 0.082 12.3 0.2 0.082 12.3 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5305) DUF3377 PF11857.8 PIK43842.1 - 0.087 12.8 1.6 0.16 11.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Calcyon PF06387.11 PIK43842.1 - 0.11 12.5 0.4 0.22 11.5 0.4 1.4 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Renin_r PF07850.14 PIK43842.1 - 0.17 12.5 0.2 0.17 12.5 0.2 2.3 3 0 0 3 3 3 0 Renin receptor-like protein Shisa PF13908.6 PIK43842.1 - 0.22 11.7 1.0 0.56 10.4 0.0 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator V-set PF07686.17 PIK43842.1 - 1 9.6 4.5 1.5 9.0 0.2 3.4 4 0 0 4 4 3 0 Immunoglobulin V-set domain RIFIN PF02009.16 PIK43842.1 - 3.3 7.5 5.8 0.48 10.3 1.0 1.8 2 0 0 2 2 2 0 Rifin Ig_3 PF13927.6 PIK43843.1 - 6.3e-20 71.6 0.8 2.2e-06 28.2 0.0 3.9 3 1 1 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK43843.1 - 3.5e-14 52.9 0.1 2e-12 47.2 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK43843.1 - 1e-13 51.1 0.1 4.3e-05 23.5 0.1 3.9 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK43843.1 - 2.3e-13 50.3 4.2 5.8e-05 23.4 0.2 3.9 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK43843.1 - 3.6e-06 27.1 0.1 0.0051 17.0 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK43843.1 - 0.0029 17.6 0.0 0.075 13.1 0.1 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Herpes_gE PF02480.16 PIK43843.1 - 0.012 14.4 0.0 0.42 9.3 0.0 2.2 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Receptor_2B4 PF11465.8 PIK43843.1 - 0.02 15.1 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 RMI1_N PF08585.12 PIK43843.1 - 0.48 10.1 3.3 0.54 10.0 0.2 1.9 1 1 0 2 2 2 0 RecQ mediated genome instability protein Com_YlbF PF06133.11 PIK43844.1 - 2.6 8.7 7.2 0.87 10.2 1.0 2.5 1 1 1 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA E3_UFM1_ligase PF09743.9 PIK43845.1 - 2.5e-112 374.9 1.1 3.4e-112 374.5 1.1 1.2 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 FancD2 PF14631.6 PIK43845.1 - 0.0069 13.9 0.1 0.0088 13.5 0.1 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease Tn7_Tnp_TnsA_C PF08721.11 PIK43845.1 - 0.021 15.4 0.3 0.15 12.7 0.0 2.4 2 0 0 2 2 2 0 TnsA endonuclease C terminal SelB-wing_2 PF09106.11 PIK43845.1 - 0.048 13.9 0.0 0.63 10.3 0.0 2.6 2 0 0 2 2 2 0 Elongation factor SelB, winged helix HTH_53 PF18606.1 PIK43845.1 - 0.11 12.2 0.0 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 Zap helix turn helix N-terminal domain BLOC1S3 PF15753.5 PIK43846.1 - 0.062 13.4 0.6 0.098 12.8 0.6 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 V-set PF07686.17 PIK43848.1 - 0.00032 20.8 0.2 0.53 10.5 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin V-set domain DUF4528 PF15031.6 PIK43848.1 - 0.053 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) C2-set_2 PF08205.12 PIK43848.1 - 0.1 12.7 1.6 0.14 12.3 0.5 1.9 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Integrase_H2C2 PF17921.1 PIK43849.1 - 2.2e-16 59.7 3.1 4.4e-16 58.7 3.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK43849.1 - 0.0024 18.1 0.0 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain ASXH PF13919.6 PIK43851.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Asx homology domain C1-set PF07654.15 PIK43852.1 - 2.6e-06 27.7 0.4 0.0034 17.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK43852.1 - 6.3e-05 23.5 0.3 0.068 13.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK43852.1 - 6.7e-05 22.9 0.2 0.00021 21.3 0.1 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK43852.1 - 0.00013 22.3 0.5 0.23 11.8 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK43852.1 - 0.00015 21.8 0.0 0.4 10.8 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK43852.1 - 0.0039 17.3 0.1 0.031 14.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK43852.1 - 0.051 13.7 0.6 3.8 7.7 0.1 2.4 2 1 0 2 2 2 0 Immunoglobulin domain NACHT PF05729.12 PIK43853.1 - 5.3e-19 68.7 0.0 7.4e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK43853.1 - 8.8e-05 22.2 0.0 0.00019 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK43853.1 - 0.00014 22.2 0.0 0.0039 17.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain DAP3 PF10236.9 PIK43853.1 - 0.13 11.4 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 PIK43853.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Glyco_hydro_59 PF02057.15 PIK43854.1 - 0.11 11.7 0.1 1.5 8.0 0.0 2.1 1 1 1 2 2 2 0 Glycosyl hydrolase family 59 V-set PF07686.17 PIK43855.1 - 0.00016 21.8 0.0 0.00022 21.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain RVT_1 PF00078.27 PIK43856.1 - 5.9e-17 61.9 0.0 7.8e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LAMTOR PF15454.6 PIK43856.1 - 0.0034 18.0 0.1 0.01 16.4 0.1 1.8 1 1 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator RVT_1 PF00078.27 PIK43857.1 - 0.044 13.3 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SPATA1_C PF15743.5 PIK43859.1 - 2.1e-30 105.8 18.0 2.8e-30 105.4 18.0 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated C-terminus SpoVIF PF14069.6 PIK43859.1 - 0.14 12.0 8.7 0.64 9.8 0.9 2.6 3 0 0 3 3 3 0 Stage VI sporulation protein F Filament PF00038.21 PIK43859.1 - 0.91 9.1 16.0 0.071 12.7 2.4 2.2 2 0 0 2 2 2 0 Intermediate filament protein DUF4407 PF14362.6 PIK43859.1 - 2.3 7.5 9.3 3.9 6.7 8.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) EHN PF06441.12 PIK43859.1 - 2.5 8.5 6.0 7.7 6.9 0.0 2.8 2 1 1 3 3 3 0 Epoxide hydrolase N terminus eIF3g PF12353.8 PIK43859.1 - 7 7.1 9.9 28 5.1 9.7 2.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G DM PF00751.18 PIK43860.1 - 8.7e-13 48.0 3.4 8.7e-13 48.0 3.4 1.9 2 0 0 2 2 2 1 DM DNA binding domain DUF241 PF03087.14 PIK43860.1 - 0.021 14.7 2.1 0.031 14.1 2.1 1.2 1 0 0 1 1 1 0 Arabidopsis protein of unknown function Ank PF00023.30 PIK43862.1 - 3.7e-23 80.9 0.5 4.1e-08 33.3 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 PIK43862.1 - 2.1e-22 79.5 0.6 5.8e-15 55.6 0.0 2.3 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK43862.1 - 1.1e-21 76.9 1.0 2.5e-12 47.1 0.0 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK43862.1 - 5.4e-20 71.2 2.4 2.3e-09 37.3 0.0 3.9 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK43862.1 - 5.3e-19 66.3 0.2 1.1e-05 25.4 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ras PF00071.22 PIK43864.1 - 3.7e-41 140.4 0.0 4.7e-41 140.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK43864.1 - 2.1e-18 66.7 0.0 3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43864.1 - 7e-08 32.1 0.0 9e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK43864.1 - 0.0027 17.3 0.0 0.0048 16.4 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK43864.1 - 0.037 13.9 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase Kunitz_BPTI PF00014.23 PIK43865.1 - 8.8e-239 771.9 208.4 1.3e-17 63.8 1.4 18.1 18 0 0 18 18 18 18 Kunitz/Bovine pancreatic trypsin inhibitor domain MAAL_N PF05034.13 PIK43865.1 - 9.3 5.9 12.8 31 4.1 0.1 5.5 6 1 1 7 7 7 0 Methylaspartate ammonia-lyase N-terminus Kunitz_BPTI PF00014.23 PIK43866.1 - 1.3e-190 617.7 123.2 5.2e-17 61.8 2.5 13.1 13 0 0 13 13 13 13 Kunitz/Bovine pancreatic trypsin inhibitor domain Ras PF00071.22 PIK43867.1 - 1.6e-30 105.8 0.0 2.2e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK43867.1 - 7.9e-09 35.8 0.0 1.5e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43867.1 - 1.1e-07 31.5 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK43867.1 - 0.0066 16.4 0.0 3.8 7.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 PIK43867.1 - 0.071 12.3 0.0 7.7 5.6 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit TDH PF03347.13 PIK43867.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin Mito_carr PF00153.27 PIK43868.1 - 5.4e-11 42.3 0.0 7.5e-11 41.8 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.27 PIK43869.1 - 4.8e-24 84.1 0.1 5.2e-24 84.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Astacin PF01400.24 PIK43870.1 - 9.3e-73 243.9 0.0 1.4e-72 243.4 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 PIK43870.1 - 7.6e-57 190.4 0.0 2.9e-22 79.1 0.0 3.3 3 0 0 3 3 3 3 CUB domain FXa_inhibition PF14670.6 PIK43870.1 - 1.1e-10 41.6 9.4 3.3e-10 40.1 9.4 1.9 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK43870.1 - 1.2e-06 28.6 9.6 3.4e-06 27.1 9.6 1.8 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.7 PIK43870.1 - 1.7e-05 24.7 0.9 6e-05 22.9 0.9 2.1 1 0 0 1 1 1 1 Complement Clr-like EGF-like EGF PF00008.27 PIK43870.1 - 0.00019 21.6 7.2 0.00058 20.1 7.2 1.8 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK43870.1 - 0.00053 20.5 5.1 0.0017 18.9 5.1 2.0 1 0 0 1 1 1 1 Human growth factor-like EGF Peptidase_M10 PF00413.24 PIK43870.1 - 0.00054 19.8 0.0 0.03 14.2 0.0 2.2 2 0 0 2 2 2 1 Matrixin EGF_3 PF12947.7 PIK43870.1 - 0.0022 18.2 8.5 0.0022 18.2 8.5 2.1 2 0 0 2 2 1 1 EGF domain Reprolysin_4 PF13583.6 PIK43870.1 - 0.008 15.8 0.1 0.014 15.1 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Plasmod_Pvs28 PF06247.11 PIK43870.1 - 0.022 15.1 2.3 0.057 13.7 2.3 1.7 1 0 0 1 1 1 0 Pvs28 EGF domain CUB PF00431.20 PIK43871.1 - 2.5e-64 214.5 0.0 2.5e-36 124.4 0.0 2.2 2 0 0 2 2 2 2 CUB domain CUB_2 PF02408.20 PIK43871.1 - 0.0077 16.0 0.1 0.32 10.8 0.0 2.5 2 0 0 2 2 2 1 CUB-like domain POPLD PF08170.12 PIK43871.1 - 0.051 13.9 0.5 0.87 10.0 0.2 2.4 2 0 0 2 2 2 0 POPLD (NUC188) domain EMP70 PF02990.16 PIK43872.1 - 2.9e-157 524.5 23.3 3.6e-157 524.2 23.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Collar PF07484.12 PIK43872.1 - 0.067 13.2 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Phage Tail Collar Domain EVC2_like PF12297.8 PIK43872.1 - 1.9 7.1 3.7 32 3.1 0.0 2.1 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein p450 PF00067.22 PIK43873.1 - 4.4e-110 368.6 0.0 5e-110 368.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sulf_coat_C PF12193.8 PIK43873.1 - 0.05 13.7 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 Sulfolobus virus coat protein C terminal PRP1_N PF06424.12 PIK43874.1 - 0.033 14.6 1.0 0.04 14.3 1.0 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Keratin_B2 PF01500.17 PIK43876.1 - 0.94 9.5 4.8 11 5.9 0.2 2.5 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein UNC119_bdg PF15435.6 PIK43877.1 - 0.039 13.5 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 UNC119-binding protein C5orf30 homologue Phage_B PF02304.15 PIK43878.1 - 0.016 15.6 0.2 0.031 14.6 0.2 1.4 1 0 0 1 1 1 0 Scaffold protein B FYVE PF01363.21 PIK43878.1 - 0.048 13.8 1.4 0.082 13.1 1.4 1.5 1 1 0 1 1 1 0 FYVE zinc finger XAF1_C PF18608.1 PIK43878.1 - 0.059 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain TRAF6_Z2 PF18048.1 PIK43878.1 - 0.15 12.2 6.7 0.28 11.3 6.7 1.3 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 rve PF00665.26 PIK43879.1 - 3.1e-05 24.1 0.0 4.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MMR_HSR1 PF01926.23 PIK43881.1 - 0.00012 22.2 1.8 0.0013 18.8 0.0 3.6 3 1 0 3 3 3 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK43881.1 - 0.00026 21.1 0.1 0.00026 21.1 0.1 4.3 5 1 0 6 6 6 1 Dynamin family Csm2_III-A PF03750.13 PIK43881.1 - 0.03 15.2 3.8 0.084 13.7 0.5 3.2 2 0 0 2 2 2 0 Csm2 Type III-A TLE_N PF03920.15 PIK43881.1 - 4.8 7.3 10.7 6.3 6.9 0.2 3.9 4 0 0 4 4 4 0 Groucho/TLE N-terminal Q-rich domain BIV_Env PF05858.12 PIK43883.1 - 0.015 13.5 0.1 0.022 13.0 0.1 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) Flu_B_NS1 PF02942.14 PIK43883.1 - 0.033 13.3 0.3 0.1 11.7 0.0 1.8 2 0 0 2 2 2 0 Influenza B non-structural protein (NS1) ATP-synt_F PF01990.17 PIK43883.1 - 0.034 14.5 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit TetR_C_37 PF18665.1 PIK43883.1 - 0.049 14.2 0.8 0.1 13.2 0.8 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain UPF0180 PF03698.13 PIK43883.1 - 0.055 13.6 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) Glyco_hydro_79C PF16862.5 PIK43883.1 - 0.061 14.2 0.0 2.5 9.0 0.0 2.4 2 1 0 2 2 2 0 Glycosyl hydrolase family 79 C-terminal beta domain Fer2_2 PF01799.20 PIK43884.1 - 7.9e-20 70.7 0.0 8.5e-20 70.6 0.0 1.0 1 0 0 1 1 1 1 [2Fe-2S] binding domain Thioredoxin PF00085.20 PIK43885.1 - 4.8e-07 29.7 0.0 1.5e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 PIK43885.1 - 0.00091 19.2 0.0 0.049 13.5 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin-like domain TBP PF00352.21 PIK43885.1 - 0.018 15.0 0.0 0.23 11.4 0.0 2.5 2 1 1 3 3 3 0 Transcription factor TFIID (or TATA-binding protein, TBP) Mitoc_L55 PF09776.9 PIK43886.1 - 1.9e-34 117.9 0.4 2.5e-34 117.4 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Pox_C7_F8A PF03287.14 PIK43886.1 - 0.067 13.2 0.1 0.082 12.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus C7/F8A protein GILT PF03227.16 PIK43887.1 - 3.9e-33 113.9 1.4 9e-33 112.7 1.4 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SapA PF02199.15 PIK43887.1 - 0.0012 19.1 4.2 0.0012 19.1 4.2 2.2 2 0 0 2 2 2 1 Saposin A-type domain Thioredoxin_4 PF13462.6 PIK43887.1 - 0.044 13.9 0.1 0.25 11.5 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin Y_phosphatase PF00102.27 PIK43888.1 - 1.1e-147 489.8 3.5 1.8e-82 276.5 0.7 3.3 2 1 1 3 3 3 3 Protein-tyrosine phosphatase fn3 PF00041.21 PIK43888.1 - 6.2e-90 295.7 34.8 1.5e-13 50.9 0.1 10.6 10 0 0 10 10 10 9 Fibronectin type III domain Ig_3 PF13927.6 PIK43888.1 - 5.3e-33 113.5 5.8 6.6e-13 49.1 0.2 5.4 5 0 0 5 5 5 3 Immunoglobulin domain I-set PF07679.16 PIK43888.1 - 2.4e-31 107.6 0.9 1.5e-13 50.6 0.0 4.8 5 0 0 5 5 4 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK43888.1 - 1.3e-22 79.9 1.9 6.1e-12 45.7 0.2 4.6 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK43888.1 - 1.8e-15 56.8 0.3 0.0026 17.9 0.0 4.5 4 0 0 4 4 3 3 Immunoglobulin domain Interfer-bind PF09294.10 PIK43888.1 - 2e-13 50.6 1.6 0.056 13.8 0.1 7.1 7 0 0 7 7 7 3 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.17 PIK43888.1 - 5e-08 33.1 0.3 0.012 15.8 0.1 4.5 3 1 0 3 3 3 2 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 PIK43888.1 - 5.5e-08 33.3 31.9 0.27 11.8 0.6 7.7 7 1 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 PIK43888.1 - 1.4e-07 31.4 0.5 0.043 13.7 0.0 5.1 5 0 0 5 5 5 2 Fibronectin-III type domain DSPc PF00782.20 PIK43888.1 - 1.2e-06 28.4 0.0 0.011 15.6 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK43888.1 - 6.5e-06 26.3 0.0 0.045 13.7 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK43888.1 - 7.1e-05 23.0 0.0 0.067 13.3 0.0 2.9 2 0 0 2 2 2 2 Inositol hexakisphosphate C2-set_2 PF08205.12 PIK43888.1 - 0.00011 22.2 0.8 0.04 14.0 0.1 4.0 3 1 1 4 4 4 1 CD80-like C2-set immunoglobulin domain DUF2369 PF10179.9 PIK43888.1 - 0.0093 16.3 0.2 17 5.9 0.0 4.4 5 0 0 5 5 3 0 Uncharacterised conserved protein (DUF2369) Tissue_fac PF01108.17 PIK43888.1 - 0.054 13.4 4.2 3.6 7.5 0.0 4.7 5 0 0 5 5 4 0 Tissue factor fn3_2 PF16893.5 PIK43888.1 - 0.51 10.5 7.2 6.5 7.0 0.0 5.5 7 0 0 7 7 6 0 Fibronectin type III domain Syndecan PF01034.20 PIK43888.1 - 0.9 9.5 2.2 81 3.2 3.4 2.4 2 0 0 2 2 2 0 Syndecan domain PHD PF00628.29 PIK43889.1 - 0.00021 21.1 6.7 0.00035 20.4 6.7 1.3 1 0 0 1 1 1 1 PHD-finger FANCL_C PF11793.8 PIK43889.1 - 0.22 11.7 3.5 0.42 10.8 3.5 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Acetyltransf_7 PF13508.7 PIK43890.1 - 6.2e-10 39.4 0.0 7.1e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK43890.1 - 1e-09 38.6 0.0 1.1e-09 38.5 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK43890.1 - 2.2e-09 37.3 0.0 2.5e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK43890.1 - 0.00014 21.8 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 PIK43890.1 - 0.0027 17.8 0.0 0.0033 17.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 PIK43890.1 - 0.021 14.4 0.0 0.022 14.4 0.0 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase DUF4201 PF13870.6 PIK43891.1 - 2.4e-05 24.2 11.1 4.1e-05 23.4 11.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF4515 PF14988.6 PIK43891.1 - 0.0014 18.5 10.6 0.003 17.4 4.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4515) Atg14 PF10186.9 PIK43891.1 - 0.011 14.9 9.5 0.015 14.4 9.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATF7IP_BD PF16788.5 PIK43891.1 - 0.012 15.7 3.2 0.018 15.1 3.2 1.3 1 0 0 1 1 1 0 ATF-interacting protein binding domain Fer4_24 PF18109.1 PIK43891.1 - 0.23 11.8 0.1 0.23 11.8 0.1 2.2 3 0 0 3 3 3 0 Ferredoxin I 4Fe-4S cluster domain LPP PF04728.13 PIK43891.1 - 0.33 11.4 5.7 3.6 8.1 0.7 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Ribosomal_L29 PF00831.23 PIK43891.1 - 0.45 10.5 4.1 1.7 8.7 0.7 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein V_ATPase_I PF01496.19 PIK43891.1 - 1.7 6.5 5.5 1.9 6.3 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 PIK43891.1 - 1.9 7.8 6.1 2.6 7.3 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 PIK43891.1 - 3 8.3 5.2 3 8.3 1.6 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Remorin_C PF03763.13 PIK43891.1 - 4.5 7.2 13.6 2.5 8.0 9.0 2.2 1 1 1 2 2 2 0 Remorin, C-terminal region DUF1043 PF06295.12 PIK43891.1 - 7.1 6.7 12.4 2.5 8.1 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF4201 PF13870.6 PIK43892.1 - 2.4e-05 24.2 11.1 4.1e-05 23.4 11.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF4515 PF14988.6 PIK43892.1 - 0.0016 18.3 10.8 0.003 17.4 4.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4515) Atg14 PF10186.9 PIK43892.1 - 0.011 14.9 9.5 0.015 14.4 9.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATF7IP_BD PF16788.5 PIK43892.1 - 0.012 15.7 3.2 0.018 15.1 3.2 1.3 1 0 0 1 1 1 0 ATF-interacting protein binding domain Fer4_24 PF18109.1 PIK43892.1 - 0.23 11.8 0.1 0.23 11.8 0.1 2.3 3 0 0 3 3 3 0 Ferredoxin I 4Fe-4S cluster domain LPP PF04728.13 PIK43892.1 - 0.33 11.4 5.7 3.6 8.1 0.7 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Ribosomal_L29 PF00831.23 PIK43892.1 - 0.45 10.5 4.1 1.7 8.7 0.7 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein DUF4407 PF14362.6 PIK43892.1 - 1.5 8.1 5.8 2.2 7.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 PIK43892.1 - 1.7 6.5 5.5 1.9 6.3 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 PIK43892.1 - 2.9 8.3 5.2 3 8.3 1.6 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Remorin_C PF03763.13 PIK43892.1 - 4.6 7.2 13.6 2.5 8.0 9.0 2.2 1 1 1 2 2 2 0 Remorin, C-terminal region DUF1043 PF06295.12 PIK43892.1 - 7.1 6.6 12.4 2.5 8.1 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) TM2 PF05154.16 PIK43893.1 - 3.5e-16 59.3 5.1 5.1e-16 58.7 5.1 1.2 1 0 0 1 1 1 1 TM2 domain EF-hand_1 PF00036.32 PIK43894.1 - 2.1e-20 70.6 8.5 1e-06 27.9 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK43894.1 - 2.1e-19 67.7 9.4 2.1e-06 27.2 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK43894.1 - 2.5e-15 55.2 9.3 6.6e-05 22.2 0.1 4.0 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 PIK43894.1 - 3.5e-14 53.0 7.9 2.4e-11 43.9 1.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK43894.1 - 7.6e-11 41.7 3.2 0.00013 21.7 0.0 3.9 3 1 1 4 4 4 3 EF-hand domain pair Ferric_reduct PF01794.19 PIK43894.1 - 1.7e-06 28.2 2.7 3.9e-06 27.0 2.7 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_9 PF14658.6 PIK43894.1 - 8.5e-06 26.0 0.2 0.00098 19.4 0.0 3.2 3 1 1 4 4 4 2 EF-hand domain EF-hand_4 PF12763.7 PIK43894.1 - 0.0033 17.3 3.1 0.23 11.5 0.0 3.4 1 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK43894.1 - 0.11 12.8 1.9 8.8 6.7 0.2 3.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Shal-type PF11601.8 PIK43894.1 - 1.4 8.5 3.9 0.4 10.3 0.7 1.8 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels, N-terminal NAD_binding_6 PF08030.12 PIK43895.1 - 4.8e-30 104.8 0.6 1.4e-29 103.2 0.0 1.8 2 0 0 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 PIK43895.1 - 0.0013 19.3 0.0 0.012 16.2 0.0 2.5 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain LOR PF04525.12 PIK43895.1 - 0.053 13.1 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 LURP-one-related CCDC24 PF15669.5 PIK43896.1 - 4.1e-53 180.3 7.4 4.1e-53 180.3 7.4 2.6 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 24 family betaPIX_CC PF16523.5 PIK43896.1 - 2 8.3 7.2 0.57 10.1 0.4 3.0 2 2 0 2 2 2 0 betaPIX coiled coil RVT_1 PF00078.27 PIK43897.1 - 6.7e-20 71.6 0.0 1.2e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPR_14 PF13428.6 PIK43897.1 - 0.0053 17.5 0.0 0.26 12.2 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43897.1 - 0.042 14.4 0.4 0.31 11.6 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43897.1 - 0.12 12.8 0.0 0.41 11.1 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1891 PF09004.10 PIK43898.1 - 7.4e-07 28.7 0.0 1.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) TPR_19 PF14559.6 PIK43898.1 - 2.5e-05 24.7 2.8 0.026 15.0 0.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2659 PF10858.8 PIK43898.1 - 0.021 14.5 0.2 0.051 13.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) TPR_8 PF13181.6 PIK43898.1 - 0.041 14.1 3.8 9.1 6.8 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43898.1 - 0.4 11.4 1.5 1e+02 3.9 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Ran_BP1 PF00638.18 PIK43899.1 - 2.6e-07 30.9 0.1 6.9e-07 29.6 0.1 1.7 1 0 0 1 1 1 1 RanBP1 domain Kelch_1 PF01344.25 PIK43900.1 - 2.7e-50 167.7 2.6 8.6e-10 38.1 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK43900.1 - 9e-39 130.5 2.8 1.6e-08 34.5 0.1 6.9 5 2 2 7 7 7 5 Kelch motif BACK PF07707.15 PIK43900.1 - 4.1e-31 107.1 1.9 2.6e-30 104.5 0.8 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 PIK43900.1 - 6.7e-26 90.0 1.2 9e-06 25.6 0.1 5.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK43900.1 - 4.5e-25 86.6 3.5 2.8e-06 27.1 0.1 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 PIK43900.1 - 5.1e-25 87.2 0.3 6.4e-06 26.3 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK43900.1 - 1.1e-12 47.7 5.1 9.2e-05 22.3 0.0 5.8 6 0 0 6 6 6 3 Kelch motif BTB PF00651.31 PIK43900.1 - 0.00054 20.2 0.1 0.0023 18.1 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain SID-1_RNA_chan PF13965.6 PIK43901.1 - 0.0086 14.5 0.2 0.0086 14.5 0.2 1.7 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 Nucleoside_tran PF01733.18 PIK43901.1 - 0.051 13.0 0.1 0.077 12.4 0.1 1.2 1 0 0 1 1 1 0 Nucleoside transporter DUF4834 PF16118.5 PIK43901.1 - 0.29 12.1 0.0 0.29 12.1 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3377 PF11857.8 PIK43901.1 - 0.42 10.6 4.8 1.1 9.2 3.2 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3377) Presenilin PF01080.17 PIK43901.1 - 5.7 5.6 6.2 7.6 5.2 0.1 2.3 2 0 0 2 2 2 0 Presenilin Zip PF02535.22 PIK43901.1 - 7.8 5.6 6.4 44 3.1 0.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter RVT_1 PF00078.27 PIK43902.1 - 1.1e-35 123.2 0.1 1.7e-35 122.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Scramblase PF03803.15 PIK43903.1 - 0.00083 18.7 0.0 0.078 12.3 0.0 2.2 1 1 0 1 1 1 1 Scramblase Pkinase_Tyr PF07714.17 PIK43904.1 - 1e-28 100.3 0.0 1.6e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43904.1 - 8.1e-20 71.3 0.0 1.3e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain O-antigen_lig PF13425.6 PIK43904.1 - 0.026 13.3 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ig_2 PF13895.6 PIK43904.1 - 0.047 14.0 0.3 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain PBP1_TM PF14812.6 PIK43904.1 - 0.25 11.7 3.0 0.5 10.8 3.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GFO_IDH_MocA PF01408.22 PIK43905.1 - 6.8e-16 59.2 0.0 1.3e-15 58.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK43905.1 - 6.3e-06 26.2 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain HECT PF00632.25 PIK43906.1 - 1.3e-32 113.5 0.1 1.5e-32 113.3 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ANAPC10 PF03256.16 PIK43907.1 - 1.4e-07 31.4 0.1 2.5e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK43907.1 - 0.0004 20.5 0.4 0.0014 18.8 0.0 2.1 2 0 0 2 2 2 1 F5/8 type C domain DUF1636 PF07845.11 PIK43908.1 - 0.021 15.3 0.1 0.028 14.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1636) DUF1174 PF06671.11 PIK43908.1 - 0.093 12.5 0.9 0.2 11.4 0.9 1.5 1 0 0 1 1 1 0 Repeat of unknown function (DUF1174) Kringle PF00051.18 PIK43909.1 - 2.1e-19 69.6 7.3 3.5e-19 68.9 7.3 1.4 1 0 0 1 1 1 1 Kringle domain Pkinase_Tyr PF07714.17 PIK43909.1 - 3.6e-13 49.4 0.0 4.7e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43909.1 - 7e-07 28.9 0.0 9.3e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43910.1 - 5e-36 124.3 0.0 6.2e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43910.1 - 1.6e-17 63.7 0.0 1.7e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 PIK43910.1 - 0.16 10.9 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain AIG1 PF04548.16 PIK43912.1 - 7.9e-42 143.0 1.9 7.9e-36 123.4 0.6 2.3 1 1 1 2 2 2 2 AIG1 family MMR_HSR1 PF01926.23 PIK43912.1 - 8.4e-09 35.5 0.2 2.3e-08 34.1 0.1 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 PIK43912.1 - 0.00097 19.5 0.1 0.0044 17.4 0.0 2.1 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.23 PIK43912.1 - 0.0011 19.0 3.6 0.3 11.1 0.0 2.8 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK43912.1 - 0.0013 18.6 0.2 0.003 17.5 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK43912.1 - 0.0014 19.1 0.8 0.015 15.8 0.8 2.4 1 1 0 1 1 1 1 ABC transporter Med10 PF09748.9 PIK43912.1 - 0.0046 16.9 0.8 0.0094 15.9 0.4 1.7 1 1 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex ATPase PF06745.13 PIK43912.1 - 0.0092 15.4 0.8 0.048 13.0 0.2 2.0 2 0 0 2 2 2 1 KaiC IIGP PF05049.13 PIK43912.1 - 0.011 14.8 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF87 PF01935.17 PIK43912.1 - 0.028 14.5 0.3 0.27 11.3 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain FeoB_N PF02421.18 PIK43912.1 - 0.031 13.8 0.0 0.088 12.3 0.0 1.9 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_10 PF12846.7 PIK43912.1 - 0.035 13.0 0.0 0.066 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain TadF PF16964.5 PIK43913.1 - 0.0052 16.6 0.3 0.009 15.8 0.3 1.3 1 0 0 1 1 1 1 Putative tight adherence pilin protein F Serpin PF00079.20 PIK43914.1 - 5.7e-79 266.1 1.5 7e-79 265.8 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LRR_4 PF12799.7 PIK43914.1 - 0.22 12.0 1.5 1.5 9.4 0.2 2.5 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) OST-HTH PF12872.7 PIK43916.1 - 1.1e-11 44.3 0.1 1.6e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 OST-HTH/LOTUS domain RRM_1 PF00076.22 PIK43917.1 - 0.15 11.9 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sugar_tr PF00083.24 PIK43918.1 - 1.1e-27 97.0 18.8 1.5e-27 96.6 18.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK43918.1 - 1.4e-21 76.8 42.9 7.9e-16 57.9 13.1 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily Glyco_transf_21 PF13506.6 PIK43918.1 - 0.084 12.3 0.0 13 5.2 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 21 DUF2567 PF10821.8 PIK43918.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2567) DENN PF02141.21 PIK43919.1 - 4e-58 196.5 2.9 6.2e-58 195.8 2.9 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 PIK43919.1 - 2.7e-14 53.6 0.1 7.4e-14 52.3 0.1 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 PIK43919.1 - 1.6e-06 28.0 2.9 3.3e-06 27.0 2.9 1.6 1 0 0 1 1 1 1 dDENN domain DUF2464 PF10240.9 PIK43919.1 - 0.075 12.6 0.0 0.59 9.7 0.0 2.1 2 0 0 2 2 2 0 Multivesicular body subunit 12 PPR_2 PF13041.6 PIK43920.1 - 1.2e-05 25.4 0.1 2.7e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 PIK43920.1 - 0.044 14.0 0.0 0.14 12.5 0.0 1.9 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 PIK43920.1 - 0.15 12.2 0.3 0.29 11.2 0.3 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain TPR_16 PF13432.6 PIK43922.1 - 5.5e-21 74.9 0.8 0.0016 19.0 0.0 7.7 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43922.1 - 1.3e-18 65.5 32.0 0.0031 17.5 0.0 13.9 14 1 0 14 14 12 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43922.1 - 1.3e-17 62.9 9.3 0.00092 19.8 0.0 12.0 9 4 4 13 13 12 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK43922.1 - 2.9e-17 61.6 28.3 0.00078 19.2 0.0 12.2 11 1 0 11 11 11 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43922.1 - 1.5e-15 57.5 23.8 0.017 15.6 0.0 10.7 10 2 1 12 12 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43922.1 - 2.3e-11 43.0 24.8 0.062 13.5 0.0 13.1 13 1 0 13 13 12 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43922.1 - 5.1e-11 42.5 19.1 2.7 8.8 0.0 13.1 14 1 0 14 14 12 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43922.1 - 2.5e-09 37.3 12.9 0.037 14.3 0.0 8.9 8 2 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43922.1 - 3.7e-07 29.7 18.9 0.019 14.6 0.0 9.1 11 1 0 11 11 11 2 TPR repeat TPR_7 PF13176.6 PIK43922.1 - 7.8e-07 28.7 9.3 0.35 11.0 0.0 7.8 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43922.1 - 1.8e-06 27.9 2.7 0.069 13.6 0.0 7.1 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK43922.1 - 2.2e-06 27.7 2.0 15 5.8 0.1 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK43922.1 - 2.8e-05 24.2 30.4 0.0047 17.1 0.7 8.8 8 1 1 10 10 9 2 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 PIK43922.1 - 0.00052 19.7 0.0 1.9 8.1 0.0 3.5 2 0 0 2 2 2 2 Bacterial type III secretion protein (HrpB1_HrpK) LppC PF04348.13 PIK43922.1 - 0.013 14.4 0.9 0.022 13.6 0.9 1.3 1 0 0 1 1 1 0 LppC putative lipoprotein TPR_4 PF07721.14 PIK43922.1 - 0.048 14.3 0.7 39 5.3 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4363 PF14276.6 PIK43922.1 - 7.4 6.7 6.4 5.2 7.2 0.9 3.2 3 0 0 3 3 2 0 Domain of unknown function (DUF4363) 7tm_1 PF00001.21 PIK43923.1 - 1.7e-57 194.7 9.8 2.2e-57 194.4 9.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK43923.1 - 2e-08 34.3 16.7 1.3e-07 31.7 11.3 2.4 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK43923.1 - 1.4e-07 31.2 20.8 7.3e-06 25.5 14.9 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK43923.1 - 3e-05 23.8 19.8 3e-05 23.8 19.8 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx RVT_1 PF00078.27 PIK43924.1 - 1.7e-19 70.2 0.0 2.1e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CotJB PF12652.7 PIK43924.1 - 0.03 14.5 0.1 0.052 13.8 0.1 1.4 1 0 0 1 1 1 0 CotJB protein Integrase_H2C2 PF17921.1 PIK43925.1 - 7.2e-09 35.6 0.2 1.6e-08 34.5 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK43925.1 - 0.0018 18.4 0.1 0.0041 17.3 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger CGI-121 PF08617.10 PIK43925.1 - 0.008 16.3 0.3 0.012 15.8 0.3 1.4 1 1 0 1 1 1 1 Kinase binding protein CGI-121 ESAG1 PF03238.13 PIK43926.1 - 0.00015 21.3 17.6 29 4.0 0.3 8.2 1 1 8 11 11 11 6 ESAG protein NDUF_C2 PF06374.11 PIK43926.1 - 0.036 14.2 6.5 26 5.0 0.0 5.4 1 1 8 9 9 9 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) DUF3180 PF11377.8 PIK43926.1 - 2.5 8.2 25.2 15 5.7 0.8 6.1 3 3 5 8 8 8 0 Protein of unknown function (DUF3180) ADH_zinc_N PF00107.26 PIK43927.1 - 3.6e-20 72.2 0.0 5.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK43927.1 - 9.1e-13 49.4 0.0 1.5e-12 48.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 PIK43927.1 - 9.9e-08 31.8 0.1 3.1e-07 30.3 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase Fibrinogen_C PF00147.18 PIK43928.1 - 1.8e-39 135.8 0.0 2.8e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Methyltransf_FA PF12248.8 PIK43928.1 - 8.6e-24 83.8 0.0 1.6e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase TRAF_BIRC3_bd PF16673.5 PIK43929.1 - 0.21 11.4 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Stealth_CR2 PF11380.8 PIK43929.1 - 3 8.1 5.4 55 4.0 5.4 2.7 1 1 0 1 1 1 0 Stealth protein CR2, conserved region 2 AMP-binding PF00501.28 PIK43930.1 - 3.7e-77 259.7 0.3 1.7e-75 254.3 0.3 2.5 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK43930.1 - 1e-20 74.5 0.2 2.1e-20 73.4 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_transf_49 PF13896.6 PIK43931.1 - 3.5e-52 177.8 0.0 4.3e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_tranf_2_2 PF10111.9 PIK43931.1 - 0.063 12.8 0.0 0.09 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 HlyIII PF03006.20 PIK43932.1 - 5.5e-34 117.8 18.2 8.3e-34 117.3 18.2 1.3 1 0 0 1 1 1 1 Haemolysin-III related Vpu PF00558.19 PIK43932.1 - 0.075 12.8 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Vpu protein UL45 PF05473.12 PIK43933.1 - 0.13 11.9 6.0 0.084 12.5 0.8 2.2 1 1 1 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like VPS13_C PF16909.5 PIK43934.1 - 6.6e-26 91.2 0.1 6.6e-26 91.2 0.1 2.5 3 0 0 3 3 3 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 PIK43934.1 - 0.0032 16.9 0.7 6.8 6.0 0.1 4.0 2 1 1 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 PIK43934.1 - 0.0036 17.6 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 PIK43937.1 - 3.7e-25 88.3 0.1 1.8e-24 86.1 0.1 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 PIK43937.1 - 2.2e-05 24.4 2.9 0.00016 21.6 1.0 3.0 2 2 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Acyl_transf_3 PF01757.22 PIK43938.1 - 5e-21 75.1 38.4 5e-21 75.1 38.4 1.9 3 0 0 3 3 3 1 Acyltransferase family Abhydrolase_1 PF00561.20 PIK43939.1 - 3.7e-10 39.9 0.0 5.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK43939.1 - 6.1e-08 33.5 0.0 8e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK43939.1 - 5.1e-07 29.2 0.0 8.8e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 RCC1 PF00415.18 PIK43940.1 - 1.3e-58 195.4 19.3 7.6e-11 42.5 0.6 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK43940.1 - 3.7e-29 99.9 34.0 5.5e-09 35.6 1.1 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 PIK43940.1 - 0.22 11.8 2.8 5.4 7.3 0.0 4.0 4 1 0 4 4 4 0 Putative heavy-metal chelation MH2 PF03166.14 PIK43941.1 - 1.6e-19 70.9 0.3 3.7e-19 69.7 0.3 1.6 1 0 0 1 1 1 1 MH2 domain IRF-3 PF10401.9 PIK43941.1 - 0.0058 16.4 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IQ PF00612.27 PIK43941.1 - 0.053 13.3 2.3 0.2 11.5 2.3 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Myosin_head PF00063.21 PIK43942.1 - 7e-136 454.2 8.3 3e-100 336.4 3.1 2.0 1 1 1 2 2 2 2 Myosin head (motor domain) RNR_N PF08343.10 PIK43942.1 - 0.0094 16.0 0.9 1 9.4 0.2 2.7 2 0 0 2 2 2 2 Ribonucleotide reductase N-terminal RNase_PH PF01138.21 PIK43943.1 - 1.5e-35 122.6 0.0 2.3e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK43943.1 - 0.017 15.2 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 7tm_2 PF00002.24 PIK43944.1 - 1.1e-22 80.6 21.7 1.7e-22 79.9 21.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK43944.1 - 4.4e-07 30.2 18.1 2.7e-06 27.7 18.1 2.5 1 0 0 1 1 1 1 Somatomedin B domain SRCR PF00530.18 PIK43945.1 - 5e-16 59.0 7.2 7.2e-13 48.9 1.9 4.0 4 1 0 4 4 4 2 Scavenger receptor cysteine-rich domain Somatomedin_B PF01033.17 PIK43945.1 - 7.4e-08 32.7 18.3 7.4e-08 32.7 18.3 2.8 2 0 0 2 2 2 1 Somatomedin B domain SRCR_2 PF15494.6 PIK43945.1 - 0.001 19.5 1.2 0.0036 17.8 1.2 1.9 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain zf-U11-48K PF05253.12 PIK43946.1 - 8.7e-08 31.9 0.1 1.2e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger RINGv PF12906.7 PIK43947.1 - 7.1e-14 51.7 13.6 1.1e-13 51.1 13.6 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 PIK43947.1 - 0.012 16.0 10.4 0.021 15.2 10.3 1.5 1 1 0 1 1 1 0 Ring finger domain PHD_4 PF16866.5 PIK43947.1 - 0.15 12.2 9.8 2.7 8.1 1.3 2.6 1 1 1 2 2 2 0 PHD-finger PHD PF00628.29 PIK43947.1 - 1.7 8.6 11.8 39 4.3 8.7 2.3 1 1 1 2 2 2 0 PHD-finger FANCL_C PF11793.8 PIK43947.1 - 2 8.7 9.7 7.1 6.9 9.4 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Choline_kinase PF01633.20 PIK43948.1 - 0.045 13.3 0.3 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase PseudoU_synth_2 PF00849.22 PIK43949.1 - 6.5e-13 49.1 0.0 9.2e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase zf-RING_UBOX PF13445.6 PIK43950.1 - 5e-09 36.0 7.1 5e-09 36.0 7.1 3.3 4 1 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK43950.1 - 5.3e-09 35.8 8.9 5.3e-09 35.8 8.9 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK43950.1 - 2.9e-07 30.2 9.7 2.9e-07 30.2 9.7 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK43950.1 - 4.8e-07 30.0 8.8 4.8e-07 30.0 8.8 3.8 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK43950.1 - 1.4e-06 28.4 9.2 1.4e-06 28.4 9.2 4.0 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK43950.1 - 0.00016 21.6 8.5 0.00016 21.6 8.5 3.7 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK43950.1 - 0.00019 21.3 14.0 0.00019 21.3 14.0 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK43950.1 - 0.036 13.9 14.2 0.036 13.9 14.2 3.8 3 2 1 4 4 4 0 Prokaryotic RING finger family 4 zf-B_box PF00643.24 PIK43950.1 - 0.045 13.9 8.8 0.045 13.9 8.8 4.7 4 1 0 5 5 5 0 B-box zinc finger Peptidase_M1 PF01433.20 PIK43951.1 - 5.4e-49 166.7 0.2 8.5e-49 166.1 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 PIK43951.1 - 3.3e-31 107.7 0.0 6.7e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 PIK43951.1 - 1.3e-27 97.2 0.0 2e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 PIK43951.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase MA superfamily Pkinase PF00069.25 PIK43953.1 - 8.4e-16 58.1 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43953.1 - 1.1e-10 41.3 0.0 1.5e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SMP_LBD PF17047.5 PIK43953.1 - 0.068 12.6 0.0 0.24 10.8 0.0 1.9 1 1 1 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain Kdo PF06293.14 PIK43953.1 - 0.11 11.8 0.0 5.3 6.3 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RVT_1 PF00078.27 PIK43954.1 - 1.1e-37 129.7 0.1 2e-37 128.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.29 PIK43954.1 - 1.3e-09 37.8 6.2 3.2e-09 36.5 6.2 1.7 1 0 0 1 1 1 1 PHD-finger Exo_endo_phos_2 PF14529.6 PIK43954.1 - 2.6e-08 33.7 0.3 8.3e-08 32.1 0.3 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK43954.1 - 0.00042 19.9 0.0 0.00094 18.8 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family C1_1 PF00130.22 PIK43954.1 - 0.004 17.0 1.8 0.004 17.0 1.8 2.4 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK43954.1 - 0.019 15.3 2.8 0.051 13.9 0.6 2.7 2 0 0 2 2 2 0 C1 domain YidD PF01809.18 PIK43954.1 - 0.027 14.4 0.3 0.079 12.8 0.3 1.8 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor zf-HC5HC2H PF13771.6 PIK43954.1 - 0.036 14.3 0.9 0.13 12.5 0.9 2.0 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RRPl_C4 PF17026.5 PIK43954.1 - 0.036 14.2 1.7 0.15 12.2 1.7 2.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF4844 PF16133.5 PIK43954.1 - 0.06 13.9 0.0 0.2 12.2 0.0 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4844) PHD_2 PF13831.6 PIK43954.1 - 0.27 10.8 6.1 1.1 8.9 6.1 2.1 1 1 0 1 1 1 0 PHD-finger DNA_RNApol_7kD PF03604.13 PIK43954.1 - 0.34 10.6 2.6 1.1 9.1 2.6 1.8 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit 7tm_1 PF00001.21 PIK43955.1 - 4.5e-40 137.6 7.5 4.5e-40 137.6 7.5 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK43955.1 - 6.7e-08 32.5 23.7 6.7e-08 32.5 23.7 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK43955.1 - 0.00048 19.6 23.6 0.0016 17.9 11.7 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Nup96 PF12110.8 PIK43955.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Nuclear protein 96 DEAD PF00270.29 PIK43956.1 - 2.1e-19 70.0 0.0 1.8e-18 67.0 0.1 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase RIG-I_C PF18119.1 PIK43956.1 - 1.2e-17 64.3 0.2 1.2e-17 64.3 0.2 2.8 3 0 0 3 3 3 1 RIG-I receptor C-terminal domain ResIII PF04851.15 PIK43956.1 - 3.8e-16 59.6 2.0 5.4e-16 59.1 0.1 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK43956.1 - 6.2e-14 52.3 0.1 2.5e-13 50.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 PIK43956.1 - 0.0012 19.1 0.1 0.0061 16.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK43956.1 - 0.0016 18.3 0.0 0.0016 18.3 0.0 3.0 3 1 1 4 4 4 1 AAA domain AAA_19 PF13245.6 PIK43956.1 - 0.0025 18.2 0.4 0.19 12.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain DUF735 PF05246.11 PIK43956.1 - 0.028 14.4 0.1 0.32 11.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF735) TniB PF05621.11 PIK43956.1 - 0.063 12.7 0.2 3 7.2 0.2 2.7 1 1 0 1 1 1 0 Bacterial TniB protein IstB_IS21 PF01695.17 PIK43956.1 - 0.067 12.9 0.0 0.22 11.3 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein Pkinase PF00069.25 PIK43957.1 - 2.4e-06 27.1 0.0 0.00012 21.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43957.1 - 0.018 14.3 0.0 0.11 11.8 0.0 1.8 1 1 1 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.25 PIK43958.1 - 5.4e-18 65.3 0.0 3.3e-17 62.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43958.1 - 3.8e-12 46.0 0.0 8e-11 41.7 0.0 2.5 1 1 2 3 3 3 1 Protein tyrosine kinase Kdo PF06293.14 PIK43958.1 - 2.9e-05 23.5 0.0 5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK43958.1 - 0.026 14.1 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 PIK43958.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK43958.1 - 0.078 12.5 0.0 4 6.9 0.0 2.4 2 0 0 2 2 2 0 Choline/ethanolamine kinase HypA PF01155.19 PIK43959.1 - 0.012 15.6 0.6 3.3 7.8 0.3 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_2 PF13639.6 PIK43959.1 - 0.021 15.2 0.9 0.021 15.2 0.9 2.3 2 0 0 2 2 2 0 Ring finger domain zinc_ribbon_9 PF14369.6 PIK43959.1 - 0.03 14.6 10.4 0.99 9.7 1.7 3.3 3 0 0 3 3 3 0 zinc-ribbon zf-C3HC4_3 PF13920.6 PIK43959.1 - 0.052 13.4 8.9 0.35 10.8 1.4 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 PIK43959.1 - 0.054 13.7 1.6 2.6 8.3 0.2 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Isy1 PF06246.12 PIK43959.1 - 0.074 12.6 0.0 0.2 11.2 0.0 1.6 2 0 0 2 2 2 0 Isy1-like splicing family FYVE PF01363.21 PIK43959.1 - 0.14 12.3 8.1 0.26 11.4 0.5 2.6 2 1 0 2 2 2 0 FYVE zinc finger DZR PF12773.7 PIK43959.1 - 1.3 9.1 8.1 6.7 6.8 0.9 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-C2HC5 PF06221.13 PIK43959.1 - 1.5 8.9 10.7 0.24 11.4 0.5 3.0 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-RING_4 PF14570.6 PIK43959.1 - 1.7 8.5 9.7 8.3 6.3 2.0 3.3 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain ADK_lid PF05191.14 PIK43959.1 - 3.3 7.8 9.1 0.097 12.7 1.0 2.5 3 0 0 3 3 3 0 Adenylate kinase, active site lid WD40 PF00400.32 PIK43960.1 - 2.9e-15 56.4 5.3 1.8e-06 28.5 0.0 6.4 6 1 1 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43960.1 - 3.9e-13 49.5 0.1 0.0083 16.4 0.0 5.0 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 PIK43960.1 - 0.00061 19.7 0.5 4 7.3 0.0 3.4 1 1 2 3 3 3 2 Region in Clathrin and VPS eIF2A PF08662.11 PIK43960.1 - 0.0009 19.2 0.3 0.089 12.7 0.1 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK43960.1 - 0.0013 17.9 2.7 1.9 7.5 0.0 5.0 4 1 1 6 6 6 1 Coatomer WD associated region NARP1 PF12569.8 PIK43960.1 - 0.0044 16.0 0.9 0.01 14.8 0.1 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_7 PF13176.6 PIK43960.1 - 0.005 16.8 0.2 0.32 11.1 0.1 3.3 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43960.1 - 0.29 11.5 1.3 1.4 9.3 0.3 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43960.1 - 0.36 11.0 4.1 0.65 10.3 0.8 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK43960.1 - 0.65 10.7 3.0 5.4 7.7 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43960.1 - 5.3 8.1 5.9 5.3 8.1 0.1 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat MBD PF01429.19 PIK43963.1 - 7e-15 54.5 0.0 1.6e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain HhH-GPD PF00730.25 PIK43963.1 - 0.007 16.8 0.0 0.021 15.3 0.0 1.8 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein Clr2_transil PF16761.5 PIK43963.1 - 0.025 15.4 0.0 0.062 14.1 0.0 1.6 1 0 0 1 1 1 0 Transcription-silencing protein, cryptic loci regulator Clr2 TPR_1 PF00515.28 PIK43964.1 - 2.3e-20 71.5 0.0 6e-06 25.8 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK43964.1 - 1.6e-16 59.0 0.2 3.3e-05 23.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK43964.1 - 2.9e-12 45.8 0.5 0.0015 18.6 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK43964.1 - 1.2e-11 44.1 0.1 8e-06 25.4 0.0 2.6 2 1 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 PIK43964.1 - 4.9e-07 30.3 0.0 0.0072 16.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK43964.1 - 3.1e-06 27.5 0.0 0.17 12.8 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK43964.1 - 6.7e-06 26.1 0.2 0.0052 16.8 0.1 3.3 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 PIK43964.1 - 8.4e-06 25.8 0.0 0.00084 19.4 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK43964.1 - 1.6e-05 25.1 0.2 0.21 11.9 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK43964.1 - 1.7e-05 24.5 0.0 0.0026 17.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK43964.1 - 1.9e-05 25.1 0.1 0.0071 16.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK43964.1 - 0.00012 22.2 0.0 0.25 11.8 0.0 3.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK43964.1 - 0.00062 20.2 0.1 0.059 14.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK43964.1 - 0.0011 18.7 1.1 0.73 9.5 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 PIK43964.1 - 0.0045 16.8 0.2 7.4 6.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 PIK43964.1 - 0.034 14.6 0.5 6.9 7.1 0.0 2.4 1 1 0 2 2 2 0 Bacterial transcriptional activator domain RPAP3_C PF13877.6 PIK43965.1 - 2.9e-23 82.2 0.3 3.9e-23 81.8 0.3 1.2 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 RhoGEF PF00621.20 PIK43966.1 - 1.2e-07 32.2 0.7 1.2e-07 32.2 0.7 1.6 2 0 0 2 2 2 1 RhoGEF domain C2-set_2 PF08205.12 PIK43967.1 - 0.00013 22.0 0.1 0.00019 21.4 0.1 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF5001 PF16392.5 PIK43967.1 - 0.077 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Ig-like domain Pkinase_Tyr PF07714.17 PIK43968.1 - 4.4e-21 75.3 0.0 7.3e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK43968.1 - 2.1e-13 50.2 0.0 3.5e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK43968.1 - 3.8e-09 36.5 1.6 8.3e-06 25.8 0.1 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK43968.1 - 0.0025 18.1 1.7 0.21 11.9 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Kinase-like PF14531.6 PIK43968.1 - 0.071 12.4 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Exo_endo_phos_2 PF14529.6 PIK43970.1 - 4.4e-05 23.3 0.1 7.3e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase SPAN PF02510.14 PIK43970.1 - 0.041 13.1 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Surface presentation of antigens protein Imm26 PF15428.6 PIK43970.1 - 0.096 12.9 0.1 0.24 11.7 0.0 1.7 1 1 1 2 2 2 0 Immunity protein 26 Potex_coat PF06184.11 PIK43970.1 - 0.1 12.2 0.0 0.86 9.2 0.0 2.0 1 1 1 2 2 2 0 Potexvirus coat protein Pkinase PF00069.25 PIK43971.1 - 3.5e-29 102.0 0.0 4.7e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK43971.1 - 6.5e-20 71.5 0.0 7.2e-20 71.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK43971.1 - 0.00054 19.4 0.0 0.00056 19.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK43971.1 - 0.01 14.7 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 PIK43971.1 - 0.055 13.4 0.1 0.44 10.4 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 PIK43971.1 - 0.16 11.0 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Ig_3 PF13927.6 PIK43972.1 - 7.1e-08 32.9 2.0 0.16 12.6 0.0 5.1 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK43972.1 - 1.6e-07 31.4 0.2 0.037 14.2 0.0 3.1 4 0 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK43972.1 - 1.3e-05 25.2 0.9 0.052 13.6 0.1 3.3 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK43972.1 - 5.1e-05 23.5 2.4 0.26 11.7 0.0 5.1 4 2 1 5 5 5 1 Immunoglobulin domain ig PF00047.25 PIK43972.1 - 0.00092 19.3 0.1 1.3 9.2 0.0 4.0 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK43972.1 - 0.0036 17.3 0.5 6.1 7.0 0.0 4.4 5 0 0 5 5 5 1 Immunoglobulin I-set domain Ribosomal_S21 PF01165.20 PIK43973.1 - 2.5e-16 59.1 0.3 2.5e-16 59.1 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein S21 TED_complement PF07678.14 PIK43974.1 - 2.2e-24 86.1 0.4 4.1e-24 85.2 0.1 1.6 2 0 0 2 2 2 1 A-macroglobulin TED domain A2M_recep PF07677.14 PIK43974.1 - 4.1e-20 72.3 0.1 8.7e-20 71.2 0.1 1.6 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain NTR PF01759.21 PIK43974.1 - 1e-08 34.9 0.0 2.4e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Exo_endo_phos_2 PF14529.6 PIK43974.1 - 3.5e-07 30.1 0.7 3.5e-06 26.9 0.3 2.4 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK43974.1 - 0.00037 20.1 0.1 0.0037 16.8 0.0 2.3 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family TED_complement PF07678.14 PIK43975.1 - 2.7e-49 167.9 0.0 4e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK43975.1 - 1.5e-27 96.7 1.8 1.7e-23 83.6 0.0 3.7 4 0 0 4 4 4 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK43975.1 - 6.6e-22 77.2 0.0 2.6e-21 75.3 0.0 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG2 PF01835.19 PIK43975.1 - 3.2e-18 66.0 0.2 7.9e-16 58.3 0.1 3.1 2 0 0 2 2 2 1 MG2 domain MG3 PF17791.1 PIK43975.1 - 3.7e-13 49.6 0.0 7.5e-12 45.4 0.0 2.6 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK43975.1 - 6.4e-11 42.3 0.4 1.6e-09 37.8 0.1 2.5 2 0 0 2 2 2 1 Macroglobulin domain MG4 MG1 PF17790.1 PIK43975.1 - 3.1e-05 24.3 0.1 8.4e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 Macroglobulin domain MG1 YL1 PF05764.13 PIK43976.1 - 1.3 9.1 6.1 1.6 8.8 5.7 1.3 1 1 0 1 1 1 0 YL1 nuclear protein BAF250_C PF12031.8 PIK43979.1 - 2e-88 296.0 0.1 3.5e-88 295.2 0.1 1.4 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.21 PIK43979.1 - 2.7e-19 69.6 0.1 9.1e-19 67.9 0.1 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Ras PF00071.22 PIK43980.1 - 9.8e-22 77.3 0.1 1.5e-20 73.4 0.1 2.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK43980.1 - 1.6e-16 60.6 0.1 8.5e-16 58.3 0.0 2.3 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK43980.1 - 2e-09 37.2 0.1 3e-08 33.3 0.0 2.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK43980.1 - 3.7e-07 30.2 0.3 2.1e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK43980.1 - 0.00057 19.4 0.0 0.0019 17.7 0.0 1.9 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK43980.1 - 0.00065 19.1 0.0 0.0018 17.7 0.0 1.8 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 PIK43980.1 - 0.033 13.7 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 PIK43980.1 - 0.041 13.3 0.0 0.17 11.3 0.0 2.0 1 0 0 1 1 1 0 Bacterial TniB protein RMI1_C PF16099.5 PIK43980.1 - 0.35 10.7 3.2 2.6 7.9 0.5 2.4 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold RVT_1 PF00078.27 PIK43981.1 - 0.011 15.3 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C2 PF00648.21 PIK43982.1 - 1.3e-09 37.5 0.2 1.5e-06 27.5 0.0 2.7 3 0 0 3 3 3 2 Calpain family cysteine protease Globin PF00042.22 PIK43982.1 - 4.3e-08 33.7 0.0 3.7e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Globin RseA_N PF03872.13 PIK43982.1 - 0.038 14.5 0.1 0.2 12.2 0.1 2.2 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain WDCP PF15390.6 PIK43983.1 - 9.9e-28 96.9 6.3 2.8e-16 59.1 3.0 2.3 2 1 0 2 2 2 2 WD repeat and coiled-coil-containing protein family Got1 PF04178.12 PIK43984.1 - 1.3e-33 115.8 18.8 2.4e-33 114.9 18.7 1.5 1 1 0 1 1 1 1 Got1/Sft2-like family DUF5466 PF17554.2 PIK43984.1 - 0.019 15.1 0.5 0.053 13.7 0.5 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5466) EI24 PF07264.11 PIK43984.1 - 0.25 11.6 15.8 0.33 11.2 15.8 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) TT_ORF1 PF02956.14 PIK43985.1 - 6 5.4 9.8 5.8 5.5 9.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 zf-CCHC PF00098.23 PIK43986.1 - 6.7e-12 44.9 12.6 4.8e-08 32.7 2.8 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK43986.1 - 0.00067 19.4 10.2 0.097 12.5 2.2 2.4 2 0 0 2 2 2 2 Zinc knuckle CSD PF00313.22 PIK43986.1 - 0.0013 18.6 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC_4 PF14392.6 PIK43986.1 - 0.037 13.8 0.3 0.037 13.8 0.3 2.1 2 0 0 2 2 2 0 Zinc knuckle eIF3g PF12353.8 PIK43986.1 - 0.34 11.3 13.2 0.35 11.3 2.2 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G 7tm_1 PF00001.21 PIK43987.1 - 2.5e-21 76.2 8.0 3.7e-21 75.6 8.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pox_A11 PF05061.13 PIK43987.1 - 0.61 9.3 3.2 0.6 9.4 1.6 1.6 2 0 0 2 2 2 0 Poxvirus A11 Protein TMEM132D_C PF15706.5 PIK43987.1 - 1.6 8.6 4.2 0.38 10.6 0.2 2.0 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term 7TM_GPCR_Srab PF10292.9 PIK43987.1 - 2 7.2 11.6 0.092 11.7 3.8 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Vta1 PF04652.16 PIK43988.1 - 5.3e-33 114.0 5.1 6.6e-33 113.7 5.1 1.1 1 0 0 1 1 1 1 Vta1 like CIMR PF00878.18 PIK43989.1 - 1.3e-140 463.1 29.8 9.1e-34 116.6 0.8 6.4 6 0 0 6 6 6 6 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 PIK43989.1 - 1.1e-35 123.8 24.4 1.4e-08 35.0 0.5 7.0 1 1 5 6 6 6 6 Autophagy-related protein 27 Man-6-P_recep PF02157.15 PIK43989.1 - 3.6e-19 68.9 2.9 2.5e-07 30.1 0.2 5.6 3 2 3 6 6 6 4 Mannose-6-phosphate receptor CIMR PF00878.18 PIK43990.1 - 2.4e-145 478.4 36.0 3.2e-29 101.9 0.1 8.1 8 0 0 8 8 8 8 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 PIK43990.1 - 2.6e-36 125.8 37.0 6.6e-12 45.8 0.8 9.9 2 2 6 8 8 8 7 Autophagy-related protein 27 Man-6-P_recep PF02157.15 PIK43990.1 - 2.2e-32 112.1 8.2 4.5e-06 26.0 0.2 7.2 3 2 3 8 8 8 6 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 PIK43990.1 - 8.3e-16 58.1 14.6 0.00024 20.8 0.1 6.9 7 0 0 7 7 7 5 Glucosidase II beta subunit-like protein PI3K_p85B PF02192.16 PIK43990.1 - 0.12 12.1 0.1 0.7 9.7 0.0 2.2 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain PI3_PI4_kinase PF00454.27 PIK43991.1 - 8.5e-26 91.3 0.0 4.9e-13 49.5 0.1 2.3 2 0 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 PIK43991.1 - 1.4e-14 53.6 0.0 3.5e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 FATC domain fn3 PF00041.21 PIK43992.1 - 0.00022 21.5 3.0 2 8.8 0.3 5.4 5 1 0 5 5 5 2 Fibronectin type III domain BetaGal_dom4_5 PF13364.6 PIK43992.1 - 0.13 12.9 0.0 36 5.0 0.0 2.7 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain NACHT PF05729.12 PIK43993.1 - 3e-09 37.0 0.0 6.1e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain WD40 PF00400.32 PIK43993.1 - 8.8e-09 35.9 16.8 2.1e-06 28.3 0.2 5.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK43993.1 - 3.1e-06 27.4 1.3 0.00091 19.5 0.2 3.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 PIK43993.1 - 1.8e-05 25.2 0.1 0.00021 21.7 0.0 2.7 3 1 0 3 3 3 1 AAA ATPase domain DUF4062 PF13271.6 PIK43993.1 - 0.00013 22.3 0.0 0.0013 19.1 0.0 2.7 3 0 0 3 3 2 1 Domain of unknown function (DUF4062) AAA_22 PF13401.6 PIK43993.1 - 0.00025 21.3 0.0 0.0015 18.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 PIK43993.1 - 0.00066 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Nup160 PF11715.8 PIK43993.1 - 0.00076 18.3 0.2 0.0015 17.2 0.2 1.5 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Hira PF07569.11 PIK43993.1 - 0.0028 17.4 0.5 0.16 11.7 0.3 2.8 1 1 1 2 2 2 1 TUP1-like enhancer of split NB-ARC PF00931.22 PIK43993.1 - 0.015 14.5 0.0 0.037 13.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain DUF533 PF04391.12 PIK43993.1 - 0.015 14.8 0.1 0.042 13.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF533) AAA_24 PF13479.6 PIK43993.1 - 0.016 15.0 0.0 0.05 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK43993.1 - 0.016 14.7 0.1 0.035 13.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 PIK43993.1 - 0.02 14.5 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 PIK43993.1 - 0.03 14.0 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Nucleoporin_N PF08801.11 PIK43993.1 - 0.048 12.4 11.5 0.17 10.6 0.2 4.1 2 1 3 5 5 5 0 Nup133 N terminal like ResIII PF04851.15 PIK43993.1 - 0.076 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 PIK43993.1 - 0.089 13.3 0.0 0.24 11.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 PIK43993.1 - 0.11 12.9 0.0 0.32 11.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 PIK43993.1 - 0.11 12.7 0.1 0.63 10.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 PIK43993.1 - 0.12 12.8 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ANAPC4_WD40 PF12894.7 PIK43994.1 - 3.4e-06 27.3 0.0 0.039 14.2 0.0 3.9 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK43994.1 - 0.00059 20.6 0.1 0.012 16.4 0.0 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40_like PF17005.5 PIK43994.1 - 0.0034 16.8 0.6 0.069 12.5 0.1 2.5 2 1 0 2 2 2 1 WD40-like domain SGL PF08450.12 PIK43994.1 - 0.019 14.6 0.0 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Nup160 PF11715.8 PIK43994.1 - 0.031 12.9 0.0 0.57 8.8 0.0 2.2 2 1 0 2 2 2 0 Nucleoporin Nup120/160 DUF4891 PF16232.5 PIK43994.1 - 0.11 13.0 0.1 0.48 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) COesterase PF00135.28 PIK43995.1 - 6.1e-98 328.9 0.0 9.7e-98 328.2 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK43995.1 - 7.8e-08 32.4 0.4 0.0058 16.5 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK43995.1 - 0.0028 17.2 0.0 0.0048 16.4 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Laminin_N PF00055.17 PIK43996.1 - 1.3e-41 142.7 0.0 1.6e-41 142.4 0.0 1.0 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) 7tm_1 PF00001.21 PIK43997.1 - 2e-27 96.2 2.3 2.4e-27 95.9 2.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK43997.1 - 5.3e-07 29.3 4.8 8.1e-07 28.7 4.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK43997.1 - 0.00051 19.5 5.3 0.00082 18.8 5.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.9 PIK43997.1 - 0.006 16.1 6.7 0.0069 15.9 5.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srab PF10292.9 PIK43997.1 - 0.015 14.3 1.1 0.066 12.1 0.4 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor DUF2852 PF11014.8 PIK43997.1 - 0.033 14.3 2.1 0.062 13.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) 7TM_GPCR_Srx PF10328.9 PIK43997.1 - 1.4 8.5 14.3 0.65 9.6 11.0 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Cse1 PF08506.10 PIK43998.1 - 2.6e-137 457.6 11.8 8.7e-134 446.0 9.2 2.4 1 1 1 2 2 2 2 Cse1 CAS_CSE1 PF03378.15 PIK43998.1 - 5.2e-67 226.3 5.5 1.4e-48 165.5 0.0 3.4 4 0 0 4 4 4 2 CAS/CSE protein, C-terminus IBN_N PF03810.19 PIK43998.1 - 6e-12 45.3 0.0 2.5e-11 43.3 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT PF02985.22 PIK43998.1 - 0.055 13.7 0.7 28 5.3 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat UME PF08064.13 PIK43998.1 - 0.071 13.0 0.2 0.87 9.5 0.0 2.8 3 0 0 3 3 3 0 UME (NUC010) domain zf-RanBP PF00641.18 PIK44000.1 - 1.6e-46 155.2 42.9 3.5e-11 42.2 3.3 5.4 5 0 0 5 5 5 5 Zn-finger in Ran binding protein and others Nup153 PF08604.10 PIK44000.1 - 2.4e-19 69.5 31.4 2.2e-15 56.5 18.3 4.9 3 2 0 4 4 4 2 Nucleoporin Nup153-like DUF5537 PF17690.1 PIK44002.1 - 1e-06 28.5 0.0 1.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5537) Integrase_H2C2 PF17921.1 PIK44003.1 - 6.2e-08 32.6 0.6 6.2e-08 32.6 0.6 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK44003.1 - 1.7e-07 31.5 0.1 2.9e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK44003.1 - 0.0023 18.1 0.4 0.0062 16.7 0.4 1.8 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC_6 PF15288.6 PIK44003.1 - 0.09 12.6 0.3 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Zinc knuckle Peptidase_A17 PF05380.13 PIK44004.1 - 4.9e-58 195.7 0.0 1.9e-57 193.8 0.0 1.9 2 0 0 2 2 2 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK44004.1 - 5.3e-05 22.8 0.0 0.00016 21.3 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44004.1 - 0.00012 22.0 0.0 0.0005 20.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44004.1 - 0.00034 20.8 0.0 0.00084 19.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF1759 PF03564.15 PIK44005.1 - 0.03 14.3 0.0 0.09 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) Cyclase_polyket PF04673.12 PIK44005.1 - 0.066 13.5 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 0 Polyketide synthesis cyclase SWIRM PF04433.17 PIK44006.1 - 2.9e-34 117.3 1.0 9.9e-16 57.9 0.1 2.9 2 0 0 2 2 2 2 SWIRM domain Myb_DNA-binding PF00249.31 PIK44006.1 - 2e-15 56.7 0.3 6.7e-15 55.0 0.3 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain JAB PF01398.21 PIK44006.1 - 2.4e-10 40.4 0.0 1.1e-09 38.3 0.0 2.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 PIK44006.1 - 2.8e-08 33.5 0.1 6.2e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_6 PF13921.6 PIK44006.1 - 1e-07 32.1 0.5 3.4e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK44006.1 - 3.1e-05 23.8 0.2 0.00018 21.3 0.2 2.3 1 0 0 1 1 1 1 Myb DNA-binding like PHA_synth_III_E PF09712.10 PIK44006.1 - 0.033 13.3 0.4 0.076 12.1 0.4 1.5 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) MFS_1 PF07690.16 PIK44007.1 - 3.2e-32 111.8 30.9 7.1e-21 74.5 26.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK44007.1 - 2.5e-12 46.4 21.5 5.6e-10 38.6 7.0 3.3 1 1 2 3 3 3 3 MFS_1 like family SOCS_box PF07525.16 PIK44008.1 - 1e-05 25.7 1.0 2.7e-05 24.4 1.0 1.7 1 0 0 1 1 1 1 SOCS box WD40 PF00400.32 PIK44008.1 - 0.0004 21.1 7.7 0.032 15.1 0.1 5.0 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44008.1 - 0.0066 16.7 0.0 0.57 10.5 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 PIK44009.1 - 9.8e-40 136.6 0.0 1.4e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44009.1 - 4.1e-23 82.0 0.0 5.5e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK44009.1 - 7.8e-11 41.8 0.0 9.4e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Importin_rep_3 PF18806.1 PIK44010.1 - 2.9e-25 88.1 0.0 8.2e-25 86.7 0.0 1.9 1 0 0 1 1 1 1 Importin 13 repeat Importin_rep PF18773.1 PIK44010.1 - 8.1e-24 83.0 1.2 1.6e-23 82.1 1.2 1.5 1 0 0 1 1 1 1 Importin 13 repeat Xpo1 PF08389.12 PIK44010.1 - 1e-18 67.8 0.4 1e-18 67.8 0.4 4.8 3 2 2 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 PIK44010.1 - 2.2e-06 27.5 1.4 3.3e-05 23.7 0.1 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain HBS1_N PF08938.10 PIK44010.1 - 0.00056 20.2 0.0 0.003 17.8 0.0 2.2 2 0 0 2 2 2 1 HBS1 N-terminus CLASP_N PF12348.8 PIK44010.1 - 0.04 13.5 0.4 3.5 7.1 0.1 3.0 3 0 0 3 3 3 0 CLASP N terminal DUF1943 PF09172.11 PIK44011.1 - 2.8e-58 197.6 0.1 4.1e-58 197.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.22 PIK44011.1 - 2.5e-32 112.1 1.2 4.4e-32 111.3 1.2 1.4 1 0 0 1 1 1 1 Lipoprotein amino terminal region VWD PF00094.25 PIK44012.1 - 1.3e-11 45.0 1.3 1.3e-10 41.8 0.1 3.7 2 0 0 2 2 2 1 von Willebrand factor type D domain DUF1081 PF06448.11 PIK44012.1 - 6.2e-11 42.7 0.7 3.9e-09 36.9 0.0 3.9 4 0 0 4 4 4 1 Domain of Unknown Function (DUF1081) Apolipoprotein PF01442.18 PIK44012.1 - 2.4e-05 24.3 5.2 2.4e-05 24.3 5.2 4.5 3 1 0 3 3 3 2 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 PIK44012.1 - 0.044 13.9 0.1 0.044 13.9 0.1 7.2 7 2 2 9 9 9 0 Apolipophorin-III precursor (apoLp-III) VWA_2 PF13519.6 PIK44012.1 - 0.055 14.1 1.8 2.9 8.6 0.0 4.2 3 0 0 3 3 3 0 von Willebrand factor type A domain ParE_toxin PF05016.15 PIK44012.1 - 0.14 12.8 0.0 0.81 10.3 0.0 2.3 1 0 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE DUF883 PF05957.13 PIK44012.1 - 1.8 9.2 9.2 20 5.9 0.1 4.7 4 1 0 5 5 5 0 Bacterial protein of unknown function (DUF883) Med9 PF07544.13 PIK44012.1 - 5.9 7.1 8.9 0.35 11.0 0.1 3.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Sulfotransfer_3 PF13469.6 PIK44013.1 - 0.031 14.6 0.0 0.06 13.7 0.0 1.4 1 1 0 1 1 1 0 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK44014.1 - 0.032 14.6 0.0 0.085 13.2 0.0 1.5 1 1 0 1 1 1 0 Sulfotransferase family WD40 PF00400.32 PIK44016.1 - 8.3e-29 99.2 12.5 2.3e-06 28.2 0.2 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44016.1 - 5.2e-22 78.0 3.2 7.1e-08 32.6 0.1 4.6 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK44016.1 - 1.8e-06 27.1 0.7 0.077 11.9 0.4 3.8 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK44016.1 - 1.9e-05 24.6 0.1 0.13 12.1 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK44016.1 - 0.00038 19.2 0.5 0.36 9.4 0.1 2.6 3 0 0 3 3 3 2 Nucleoporin Nup120/160 ELYS-bb PF16687.5 PIK44016.1 - 0.013 14.1 0.0 0.022 13.4 0.0 1.2 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin Ig_3 PF13927.6 PIK44017.1 - 0.00028 21.4 0.0 68 4.2 0.0 4.8 3 2 2 5 5 5 2 Immunoglobulin domain Form-deh_trans PF09163.11 PIK44017.1 - 0.0042 16.8 9.6 75 3.2 0.0 7.1 6 2 2 8 8 8 3 Formate dehydrogenase N, transmembrane zf-B_box PF00643.24 PIK44018.1 - 0.00047 20.2 2.2 0.0013 18.9 2.2 1.7 1 0 0 1 1 1 1 B-box zinc finger DED PF01335.21 PIK44019.1 - 9.7e-05 22.6 1.1 0.00026 21.2 1.1 1.8 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 PIK44019.1 - 0.019 15.1 0.1 0.042 14.0 0.1 1.6 1 0 0 1 1 1 0 Death domain Snapin_Pallidin PF14712.6 PIK44019.1 - 0.11 13.0 0.6 0.22 12.0 0.6 1.4 1 0 0 1 1 1 0 Snapin/Pallidin GIY-YIG PF01541.24 PIK44020.1 - 1.7e-05 25.0 0.0 3.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain C2 PF00168.30 PIK44021.1 - 4.3e-25 88.0 0.1 5.7e-25 87.6 0.1 1.2 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK44022.1 - 2.2e-22 79.3 0.2 2.7e-22 79.0 0.2 1.1 1 0 0 1 1 1 1 C2 domain Ldl_recept_a PF00057.18 PIK44024.1 - 7.9e-171 554.0 357.1 7.3e-11 42.1 13.9 21.6 21 0 0 21 21 21 20 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK44024.1 - 1.2e-24 86.5 11.6 0.00034 21.0 0.0 9.7 8 2 0 8 8 8 6 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.15 PIK44024.1 - 5.7e-11 42.4 40.7 2.3e-07 30.9 4.8 20.0 11 6 9 21 21 21 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK44024.1 - 2.2e-08 34.2 41.1 1.4e-05 25.2 9.8 9.4 9 1 1 10 10 10 4 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 PIK44024.1 - 2.7e-07 30.1 0.0 0.16 11.1 0.0 4.1 4 0 0 4 4 4 2 Domain of unknown function (DUF5050) cEGF PF12662.7 PIK44024.1 - 2.6e-06 27.3 3.7 2.6e-06 27.3 3.7 7.7 7 0 0 7 7 7 3 Complement Clr-like EGF-like EGF PF00008.27 PIK44024.1 - 0.0029 17.9 3.1 0.0029 17.9 3.1 18.6 22 0 0 22 22 22 2 EGF-like domain hEGF PF12661.7 PIK44024.1 - 0.03 14.9 0.6 0.03 14.9 0.6 16.5 20 0 0 20 20 20 0 Human growth factor-like EGF NHL PF01436.21 PIK44024.1 - 0.15 12.1 8.0 27 5.0 0.2 5.7 5 0 0 5 5 5 0 NHL repeat DUF3844 PF12955.7 PIK44025.1 - 0.018 15.2 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) OAD_gamma PF04277.13 PIK44025.1 - 0.024 15.2 0.1 0.039 14.5 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain EGF PF00008.27 PIK44025.1 - 0.036 14.4 1.9 0.25 11.7 0.4 2.3 2 0 0 2 2 2 0 EGF-like domain DUF3357 PF11837.8 PIK44025.1 - 0.076 13.5 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF2207 PF09972.9 PIK44025.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 PIK44026.1 - 2.4e-27 95.6 11.2 2.9e-27 95.4 6.3 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Comm PF15957.5 PIK44026.1 - 0.025 14.9 0.0 0.035 14.4 0.0 1.4 1 1 0 1 1 1 0 Commissureless FAM176 PF14851.6 PIK44026.1 - 0.028 14.1 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 FAM176 family Sushi PF00084.20 PIK44027.1 - 5.4e-13 49.3 5.6 1.2e-08 35.4 1.4 3.0 3 1 0 3 3 3 2 Sushi repeat (SCR repeat) I-EGF_1 PF18372.1 PIK44027.1 - 0.26 11.4 3.5 2.5 8.3 0.1 3.3 3 0 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 Sushi PF00084.20 PIK44029.1 - 3.1e-25 88.5 19.3 1.2e-09 38.6 0.9 5.0 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) MVL PF12151.8 PIK44029.1 - 0.0056 16.5 1.0 0.055 13.3 0.2 2.7 2 0 0 2 2 2 1 Mannan-binding protein DUF5450 PF17529.2 PIK44029.1 - 0.06 13.5 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5450) cEGF PF12662.7 PIK44029.1 - 0.34 10.9 7.2 2.4 8.2 0.4 3.6 3 0 0 3 3 3 0 Complement Clr-like EGF-like ig PF00047.25 PIK44030.1 - 0.0001 22.4 0.1 0.00033 20.8 0.1 1.9 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK44030.1 - 0.00011 22.8 0.0 0.00049 20.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK44030.1 - 0.0055 16.9 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK44030.1 - 0.048 14.0 0.0 0.11 12.8 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Exo_endo_phos_2 PF14529.6 PIK44031.1 - 5.7e-06 26.2 0.1 1.1e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK44031.1 - 0.0012 18.4 0.4 0.0021 17.6 0.4 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sushi PF00084.20 PIK44031.1 - 0.0016 19.0 0.5 0.0059 17.2 0.5 2.0 1 1 0 1 1 1 1 Sushi repeat (SCR repeat) RT_RNaseH_2 PF17919.1 PIK44032.1 - 1.4e-33 114.9 0.0 3.2e-33 113.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44032.1 - 2.3e-21 76.0 0.0 6e-21 74.7 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44032.1 - 0.013 15.0 0.1 0.025 14.1 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Sushi PF00084.20 PIK44033.1 - 2.8e-21 75.9 5.8 2.1e-10 41.0 1.1 2.2 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.22 PIK44033.1 - 0.0044 17.3 2.8 0.59 10.5 0.2 2.4 2 0 0 2 2 2 2 Hormone receptor domain Rft-1 PF04506.13 PIK44034.1 - 3.4e-119 398.9 19.7 2.1e-118 396.3 19.7 1.9 1 1 0 1 1 1 1 Rft protein RRM_1 PF00076.22 PIK44035.1 - 3.7e-08 33.1 0.1 8e-08 32.0 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK44035.1 - 0.0031 17.6 0.0 0.0051 16.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif SMRP1 PF15181.6 PIK44035.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 Adeno_PV PF03910.13 PIK44036.1 - 1 8.0 9.3 0.12 11.1 4.4 1.9 2 0 0 2 2 2 0 Adenovirus minor core protein PV FXa_inhibition PF14670.6 PIK44037.1 - 7.8e-103 336.4 281.7 2e-09 37.6 8.7 17.8 15 2 2 17 17 17 17 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK44037.1 - 1.4e-87 287.7 309.2 8.1e-09 35.5 9.4 17.9 16 2 1 17 17 17 15 Calcium-binding EGF domain cEGF PF12662.7 PIK44037.1 - 3.4e-85 279.4 160.6 8e-11 41.7 1.7 18.2 17 0 0 17 17 17 15 Complement Clr-like EGF-like CUB PF00431.20 PIK44037.1 - 1.7e-65 218.2 4.6 5.4e-32 110.4 0.0 3.5 3 0 0 3 3 3 2 CUB domain EGF_3 PF12947.7 PIK44037.1 - 1.5e-28 98.6 249.5 0.00014 22.0 10.1 19.0 16 2 2 18 18 18 16 EGF domain EGF PF00008.27 PIK44037.1 - 4.3e-17 62.1 256.9 0.0075 16.6 1.9 18.9 18 1 0 18 18 18 14 EGF-like domain hEGF PF12661.7 PIK44037.1 - 0.0014 19.2 2.4 0.0014 19.2 2.4 20.4 18 2 0 18 18 18 9 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK44037.1 - 0.0056 17.0 2.7 0.0056 17.0 2.7 17.4 15 2 1 16 16 16 4 Pvs28 EGF domain DUF4375 PF14300.6 PIK44037.1 - 0.053 13.8 1.1 42 4.4 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4375) Ins_P5_2-kin PF06090.12 PIK44038.1 - 6.7e-60 203.3 0.5 8e-60 203.0 0.5 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase GARP PF16731.5 PIK44038.1 - 0.065 12.9 0.4 0.11 12.1 0.4 1.3 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Fn3-like PF14310.6 PIK44038.1 - 0.077 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III-like domain Packaging_FI PF14000.6 PIK44038.1 - 0.45 11.0 1.6 1.3 9.5 0.7 2.1 2 0 0 2 2 2 0 DNA packaging protein FI Pkinase PF00069.25 PIK44039.1 - 4.3e-08 32.8 0.0 1.8e-07 30.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44039.1 - 3.1e-05 23.4 0.0 0.021 14.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase PEHE PF15275.6 PIK44039.1 - 0.084 13.5 4.1 0.15 12.7 4.1 1.3 1 0 0 1 1 1 0 PEHE domain FTCD_C PF04961.12 PIK44039.1 - 0.17 11.6 2.2 0.28 10.9 2.2 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase NPR3 PF03666.13 PIK44039.1 - 0.56 8.9 6.0 0.81 8.4 6.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4551 PF15087.6 PIK44039.1 - 2.7 6.7 7.2 3.8 6.2 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) LRR_8 PF13855.6 PIK44040.1 - 1.6e-11 43.8 9.9 1.7e-07 30.9 1.1 3.5 1 1 2 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK44040.1 - 8.5e-08 32.4 15.3 0.00048 20.4 0.1 4.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44040.1 - 6.3e-06 25.8 6.0 0.00036 20.1 1.6 2.0 1 1 1 2 2 2 2 Leucine-rich repeat Adeno_E3_CR2 PF02439.15 PIK44040.1 - 0.034 13.9 1.4 0.034 13.9 1.4 1.6 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DUF4448 PF14610.6 PIK44040.1 - 0.039 13.7 0.1 0.066 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LRRC37AB_C PF14914.6 PIK44040.1 - 0.051 13.5 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF5527 PF17665.1 PIK44040.1 - 0.065 12.8 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DUF3377 PF11857.8 PIK44040.1 - 0.12 12.3 2.0 0.25 11.3 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Insulin_TMD PF17870.1 PIK44040.1 - 5.4 7.2 9.2 0.24 11.5 3.1 1.9 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment HYR PF02494.16 PIK44041.1 - 4.3e-42 142.3 8.3 9.1e-15 54.8 0.1 3.5 3 1 1 4 4 4 3 HYR domain Shisa PF13908.6 PIK44041.1 - 0.031 14.5 1.1 0.047 13.9 1.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK44041.1 - 0.29 11.0 4.3 0.23 11.4 2.0 1.8 1 1 1 2 2 2 0 TMEM154 protein family ITI_HC_C PF06668.12 PIK44042.1 - 1.1e-30 106.7 0.0 2.1e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA PF00092.28 PIK44042.1 - 6.3e-22 78.7 0.2 1e-21 77.9 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 PIK44042.1 - 1.7e-17 63.8 0.0 3e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK44042.1 - 3.7e-11 43.6 0.4 7e-11 42.7 0.4 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF3213 PF11491.8 PIK44043.1 - 0.0084 16.3 0.2 0.022 14.9 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3213) NACHT PF05729.12 PIK44045.1 - 9.6e-07 28.9 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF4723 PF15851.5 PIK44045.1 - 0.02 15.0 0.4 0.057 13.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4723) AAA_25 PF13481.6 PIK44045.1 - 0.027 14.0 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain BLYB PF05289.11 PIK44045.1 - 0.096 12.9 1.4 0.36 11.1 1.4 2.0 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein DUF3800 PF12686.7 PIK44045.1 - 0.44 11.2 2.0 19 5.9 2.0 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) NACHT PF05729.12 PIK44047.1 - 1.6e-08 34.6 0.0 4e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK44047.1 - 0.026 14.1 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain BLYB PF05289.11 PIK44047.1 - 0.032 14.5 0.5 0.1 12.8 0.5 1.9 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein PNMA PF14893.6 PIK44050.1 - 0.00017 21.1 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK44050.1 - 0.0024 18.1 0.0 0.0063 16.8 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein Retrotran_gag_2 PF14223.6 PIK44050.1 - 0.1 12.3 0.0 0.39 10.4 0.0 2.0 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type gag-asp_proteas PF13975.6 PIK44051.1 - 9.8e-09 35.7 0.0 4.5e-08 33.6 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK44051.1 - 2.1e-07 31.5 0.1 2.6e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 PIK44051.1 - 0.00022 21.5 0.1 0.00067 19.9 0.1 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease SlyX PF04102.12 PIK44051.1 - 0.068 13.8 0.2 0.23 12.1 0.2 1.8 1 0 0 1 1 1 0 SlyX RT_RNaseH_2 PF17919.1 PIK44052.1 - 4.3e-17 62.0 0.0 6.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44052.1 - 2.5e-05 24.5 0.0 0.00081 19.7 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK44053.1 - 8.5e-26 90.5 0.1 1.4e-25 89.8 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44053.1 - 1.6e-19 69.7 1.4 3.3e-19 68.7 1.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK44053.1 - 0.0001 22.4 0.7 0.00027 21.1 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK44053.1 - 0.00032 20.4 0.1 0.00091 19.0 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Gifsy-2 PF13856.6 PIK44053.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage NDK PF00334.19 PIK44055.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Nucleoside diphosphate kinase CDC45 PF02724.14 PIK44055.1 - 2.7 6.2 10.0 4 5.6 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 PIK44055.1 - 4.5 6.9 6.9 10 5.8 6.9 1.5 1 0 0 1 1 1 0 FAM176 family Methyltransf_23 PF13489.6 PIK44056.1 - 4.5e-07 29.8 0.0 7.8e-07 29.1 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK44056.1 - 0.0013 19.3 0.0 0.002 18.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK44056.1 - 0.0031 18.2 0.0 0.0048 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DM PF00751.18 PIK44057.1 - 3.8e-22 77.9 13.0 3.8e-22 77.9 13.0 1.7 2 0 0 2 2 2 1 DM DNA binding domain Arf PF00025.21 PIK44058.1 - 7.6e-28 97.1 0.0 9e-28 96.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK44058.1 - 0.0063 16.0 0.2 0.0074 15.7 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK44058.1 - 0.089 11.9 0.1 0.11 11.6 0.1 1.0 1 0 0 1 1 1 0 G-protein alpha subunit Endonuclease_7 PF02945.15 PIK44058.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Recombination endonuclease VII zf-B_box PF00643.24 PIK44059.1 - 3.8e-08 33.4 7.3 3.8e-08 33.4 7.3 4.4 4 0 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK44059.1 - 1.2e-06 28.4 9.4 1.2e-06 28.4 9.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK44059.1 - 1e-05 25.8 7.9 1e-05 25.8 7.9 3.7 3 1 1 4 4 4 1 Ring finger domain Arf PF00025.21 PIK44059.1 - 2.4e-05 23.9 0.0 5.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family zf-RING_5 PF14634.6 PIK44059.1 - 2.9e-05 23.9 8.4 2.9e-05 23.9 8.4 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK44059.1 - 0.00023 20.9 8.0 0.00023 20.9 8.0 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK44059.1 - 0.0016 18.6 5.5 0.0016 18.6 5.5 3.5 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK44059.1 - 0.0019 18.0 9.0 0.0019 18.0 9.0 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK44059.1 - 0.014 15.3 6.4 0.014 15.3 6.4 2.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 DUF948 PF06103.11 PIK44059.1 - 0.17 12.1 1.6 0.48 10.7 0.5 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Pro_CA PF00484.19 PIK44059.1 - 0.91 9.8 0.0 0.91 9.8 0.0 2.9 3 1 0 3 3 3 0 Carbonic anhydrase DUF974 PF06159.13 PIK44060.1 - 3.1e-47 161.4 0.0 3.9e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) DUF974 PF06159.13 PIK44061.1 - 2.3e-15 57.1 0.1 3.7e-15 56.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.7 PIK44061.1 - 0.00083 18.9 0.0 0.0032 17.0 0.0 1.9 2 0 0 2 2 2 1 TRAPP trafficking subunit Trs65 DNA_pol_B_palm PF14792.6 PIK44061.1 - 0.036 14.3 0.0 0.18 12.1 0.0 1.9 1 1 0 2 2 2 0 DNA polymerase beta palm Lectin_leg-like PF03388.13 PIK44062.1 - 3.2e-74 249.1 0.0 4.6e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 PIK44062.1 - 9.5e-09 35.6 0.2 3e-08 33.9 0.2 1.8 1 1 0 1 1 1 1 Bacterial lectin AA_permease_C PF13906.6 PIK44062.1 - 0.11 12.5 0.4 0.22 11.7 0.4 1.5 1 0 0 1 1 1 0 C-terminus of AA_permease DUF1664 PF07889.12 PIK44062.1 - 0.4 10.7 3.4 2.7 8.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) T3SS_HrpK1 PF16937.5 PIK44062.1 - 0.42 10.2 2.0 0.43 10.2 0.8 1.5 2 0 0 2 2 2 0 Type III secretion system translocator protein, HrpF DUF677 PF05055.12 PIK44062.1 - 2 7.2 6.7 0.63 8.9 3.4 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF677) Fib_alpha PF08702.10 PIK44062.1 - 5.3 7.2 6.5 50 4.1 0.1 3.6 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family rve PF00665.26 PIK44063.1 - 1e-20 74.1 0.0 2.2e-20 73.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK44063.1 - 0.001 18.8 0.0 0.0026 17.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK44063.1 - 0.046 14.0 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 DDE domain DUF4042 PF13251.6 PIK44063.1 - 0.053 13.2 0.0 0.49 10.1 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) DUF4070 PF13282.6 PIK44063.1 - 0.14 12.3 0.0 0.57 10.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4070) DUF1180 PF06679.12 PIK44065.1 - 0.0042 17.5 0.9 0.0076 16.7 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1180) TMEM154 PF15102.6 PIK44065.1 - 0.023 14.6 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family OAD_gamma PF04277.13 PIK44065.1 - 0.025 15.2 0.0 0.037 14.6 0.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain LapA_dom PF06305.11 PIK44065.1 - 0.038 13.8 0.1 0.071 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain WBP-1 PF11669.8 PIK44065.1 - 0.068 13.8 0.0 0.2 12.3 0.0 1.8 2 0 0 2 2 2 0 WW domain-binding protein 1 RIFIN PF02009.16 PIK44065.1 - 0.077 12.9 0.1 0.099 12.5 0.1 1.2 1 0 0 1 1 1 0 Rifin Viral_Beta_CD PF04530.12 PIK44065.1 - 0.24 11.7 2.7 0.52 10.6 0.7 2.3 2 1 0 2 2 2 0 Viral Beta C/D like family CRF-BP PF05428.11 PIK44066.1 - 1.8e-53 181.4 0.0 2.3e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) Rad1 PF02144.16 PIK44066.1 - 0.057 12.5 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 Repair protein Rad1/Rec1/Rad17 Glyco_hydr_30_2 PF14587.6 PIK44066.1 - 0.15 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 NPL PF17800.1 PIK44067.1 - 8.4e-16 58.4 0.3 3.2e-15 56.6 0.3 1.9 1 0 0 1 1 1 1 Nucleoplasmin-like domain ZIP4_domain PF18292.1 PIK44068.1 - 1.2e-07 31.8 0.9 1.8e-07 31.3 0.9 1.2 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain PEX11 PF05648.14 PIK44070.1 - 1.2e-37 129.5 0.1 1.4e-37 129.3 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Isochorismatase PF00857.20 PIK44071.1 - 6.1e-31 107.9 0.4 9.9e-31 107.2 0.4 1.3 1 0 0 1 1 1 1 Isochorismatase family Glyco_trans_4_4 PF13579.6 PIK44071.1 - 0.15 12.5 0.0 0.41 11.1 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Ldl_recept_a PF00057.18 PIK44072.1 - 1.9e-12 47.2 34.8 2.7e-06 27.5 14.5 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 PIK44072.1 - 2.7e-07 30.6 20.7 1e-05 25.4 20.7 2.0 1 1 0 1 1 1 1 Glucosidase II beta subunit-like Vps51 PF08700.11 PIK44073.1 - 1.7e-25 88.9 2.5 1.7e-25 88.9 2.5 2.5 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.6 PIK44073.1 - 8.8e-20 71.3 1.6 2.5e-19 69.9 1.6 1.8 1 0 0 1 1 1 1 Exocyst complex component Sec5 Dor1 PF04124.12 PIK44073.1 - 1.9e-09 36.7 4.3 1.9e-09 36.7 4.3 2.0 2 0 0 2 2 2 1 Dor1-like family Vps54_N PF10475.9 PIK44073.1 - 7.7e-09 35.2 5.8 7.7e-09 35.2 5.8 2.3 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 PIK44073.1 - 8.9e-07 29.1 1.1 8.9e-07 29.1 1.1 3.9 5 1 0 5 5 5 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 PIK44073.1 - 7.5e-05 22.9 3.3 0.00025 21.2 1.7 2.8 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps53_N PF04100.12 PIK44073.1 - 0.0018 17.3 2.6 0.0018 17.3 2.6 2.4 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF1804 PF08822.11 PIK44073.1 - 0.0026 17.7 6.2 0.23 11.5 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1804) ACP_PD PF04336.12 PIK44073.1 - 0.052 14.0 5.4 0.14 12.5 0.1 4.2 4 1 0 4 4 4 0 Acyl carrier protein phosphodiesterase Occludin_ELL PF07303.13 PIK44073.1 - 0.13 13.0 0.3 0.13 13.0 0.3 3.4 3 1 0 3 3 3 0 Occludin homology domain FliJ PF02050.16 PIK44073.1 - 0.16 12.2 2.8 11 6.2 0.3 3.2 2 1 0 2 2 2 0 Flagellar FliJ protein DUF3375 PF11855.8 PIK44073.1 - 0.29 10.0 5.2 0.39 9.6 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) RPW8 PF05659.11 PIK44073.1 - 0.91 9.2 4.4 6.4 6.5 1.0 3.1 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fib_alpha PF08702.10 PIK44073.1 - 0.94 9.7 0.0 0.94 9.7 0.0 4.0 5 0 0 5 5 5 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 PIK44073.1 - 2.1 8.4 9.7 0.66 10.0 0.1 4.0 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCPsignal PF00015.21 PIK44073.1 - 3.7 7.3 5.3 0.96 9.2 0.5 2.4 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ApoLp-III PF07464.11 PIK44073.1 - 4.7 7.3 9.3 44 4.2 0.3 4.8 5 1 0 5 5 5 0 Apolipophorin-III precursor (apoLp-III) CENP-F_leu_zip PF10473.9 PIK44073.1 - 7.2 6.6 11.8 0.37 10.8 5.0 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HIG_1_N PF04588.13 PIK44074.1 - 3.5e-22 78.4 2.5 4.7e-22 78.0 2.5 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Arf PF00025.21 PIK44075.1 - 2.1e-25 89.1 0.1 2.4e-25 89.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK44075.1 - 8.7e-05 22.0 0.0 9.7e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK44075.1 - 0.022 14.4 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Ras family Roc PF08477.13 PIK44075.1 - 0.026 14.8 0.0 0.048 13.9 0.0 1.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK44075.1 - 0.039 13.9 0.1 0.048 13.6 0.1 1.1 1 0 0 1 1 1 0 RsgA GTPase GTP_EFTU PF00009.27 PIK44075.1 - 0.049 13.2 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 PIK44075.1 - 0.073 12.2 0.0 0.16 11.1 0.0 1.7 1 1 0 1 1 1 0 G-protein alpha subunit ATP-synt_E PF05680.12 PIK44076.1 - 1.1e-16 60.9 0.3 1.3e-16 60.7 0.3 1.1 1 0 0 1 1 1 1 ATP synthase E chain Acyltransferase PF01553.21 PIK44077.1 - 1.3e-12 47.4 0.1 2.7e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase CAS_C PF12026.8 PIK44077.1 - 0.017 15.2 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain 7tm_1 PF00001.21 PIK44079.1 - 4.2e-68 229.5 8.1 5.2e-68 229.2 8.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK44079.1 - 3.1e-10 40.1 5.1 3.1e-10 40.1 5.1 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK44079.1 - 2.5e-07 30.3 14.3 3.2e-07 30.0 4.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Cullin PF00888.22 PIK44080.1 - 7.3e-11 41.4 0.0 9.4e-11 41.0 0.0 1.2 1 0 0 1 1 1 1 Cullin family SPG48 PF14764.6 PIK44080.1 - 0.01 16.3 0.2 2.1 8.8 0.1 2.5 2 1 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking Mon1 PF03164.14 PIK44081.1 - 0.28 10.2 5.7 1.5 7.8 0.3 2.5 2 1 0 2 2 2 0 Trafficking protein Mon1 HEAT PF02985.22 PIK44082.1 - 4.6e-07 29.6 0.3 1.7 9.1 0.0 5.1 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 PIK44082.1 - 2.7e-06 27.7 0.7 3.5 8.2 0.0 4.9 4 1 1 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.6 PIK44082.1 - 0.0019 18.6 0.2 15 6.0 0.1 4.5 4 2 1 5 5 5 2 HEAT repeats DUF3535 PF12054.8 PIK44082.1 - 0.0035 16.6 2.2 0.049 12.9 0.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF3535) Mit_KHE1 PF10173.9 PIK44082.1 - 0.051 13.7 1.4 0.17 12.0 0.1 2.5 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related DUF1444 PF07285.11 PIK44082.1 - 0.078 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1444) X PF00739.19 PIK44083.1 - 0.12 12.5 0.9 0.17 12.0 0.9 1.3 1 0 0 1 1 1 0 Trans-activation protein X DUF3652 PF12372.8 PIK44084.1 - 9.5e-15 54.2 0.2 2.5e-14 52.9 0.2 1.8 1 0 0 1 1 1 1 Huntingtin protein region DUF4745 PF15923.5 PIK44084.1 - 0.11 12.5 0.5 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) Uso1_p115_C PF04871.13 PIK44084.1 - 0.3 11.4 1.2 0.71 10.2 1.2 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Acetyltransf_16 PF05301.11 PIK44085.1 - 0.13 12.0 10.3 4.8 6.9 0.2 4.2 2 1 2 4 4 4 0 GNAT acetyltransferase, Mec-17 Dynactin_p22 PF07426.11 PIK44085.1 - 0.33 10.8 7.6 0.34 10.7 0.7 3.2 1 1 1 2 2 2 0 Dynactin subunit p22 DUF1773 PF08593.10 PIK44085.1 - 1.5 9.9 16.7 4.9e+02 1.8 0.1 8.4 9 0 0 9 9 9 0 Domain of unknown function PLU-1 PF08429.11 PIK44085.1 - 1.6 7.8 6.4 8.5 5.4 6.0 2.1 1 1 0 1 1 1 0 PLU-1-like protein Kunitz_BPTI PF00014.23 PIK44086.1 - 1.2e-66 220.8 55.7 1.5e-17 63.5 8.5 5.3 4 0 0 4 4 4 4 Kunitz/Bovine pancreatic trypsin inhibitor domain I-set PF07679.16 PIK44086.1 - 2.6e-44 149.2 0.0 2.9e-14 52.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK44086.1 - 5.3e-43 145.5 4.3 6.3e-13 49.1 0.0 5.1 6 0 0 6 6 6 3 Immunoglobulin domain Ig_2 PF13895.6 PIK44086.1 - 2.2e-30 104.8 0.0 1.6e-10 41.1 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK44086.1 - 3e-24 85.0 0.0 5.5e-09 36.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain TSP_1 PF00090.19 PIK44086.1 - 1.9e-16 60.0 83.1 2.4e-05 24.4 4.7 8.8 8 1 0 8 8 8 6 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 PIK44086.1 - 2.9e-14 53.1 0.0 1.1e-13 51.2 0.0 2.0 3 0 0 3 3 3 1 ADAM-TS Spacer 1 Thyroglobulin_1 PF00086.18 PIK44086.1 - 2.2e-12 46.4 1.7 9.2e-12 44.5 1.7 2.1 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat V-set PF07686.17 PIK44086.1 - 3.9e-10 39.9 7.7 0.023 14.9 0.0 5.9 5 1 0 5 5 5 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK44086.1 - 1.1e-07 31.2 0.0 0.1 12.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Transket_pyr PF02779.24 PIK44087.1 - 1.2e-58 197.8 0.0 3e-58 196.4 0.0 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 PIK44087.1 - 8.4e-46 155.4 0.0 1.3e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 PIK44087.1 - 3.9e-38 131.1 0.0 8.7e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 Dehydrogenase E1 component Paf1 PF03985.13 PIK44088.1 - 1.9e-103 346.7 7.1 2.3e-103 346.4 7.1 1.0 1 0 0 1 1 1 1 Paf1 Paf1 PF03985.13 PIK44089.1 - 2e-32 112.7 18.6 2e-32 112.7 18.6 2.1 1 1 1 2 2 2 1 Paf1 Glyco_transf_49 PF13896.6 PIK44090.1 - 2.8e-46 158.4 0.4 3.6e-46 158.1 0.4 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_tranf_2_2 PF10111.9 PIK44090.1 - 0.0062 16.0 0.0 0.021 14.3 0.0 1.8 1 1 0 2 2 2 1 Glycosyltransferase like family 2 Sec1 PF00995.23 PIK44091.1 - 1.2e-111 374.8 3.6 1.4e-107 361.3 2.4 2.0 2 0 0 2 2 2 2 Sec1 family GlutR_dimer PF00745.20 PIK44091.1 - 0.14 12.6 0.1 43 4.6 0.1 2.8 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain LRR_6 PF13516.6 PIK44093.1 - 0.17 12.0 0.4 16 5.9 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeat zf-C2H2 PF00096.26 PIK44094.1 - 3e-18 65.2 70.4 0.00051 20.3 2.0 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44094.1 - 8.8e-14 51.0 64.5 0.058 14.3 1.7 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK44094.1 - 1.3e-12 47.6 71.2 3.2e-06 27.3 0.2 9.3 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK44094.1 - 0.0014 18.5 49.4 0.76 9.8 0.7 8.3 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK44094.1 - 0.0047 17.2 32.4 0.04 14.2 4.9 4.5 1 1 3 4 4 4 2 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 PIK44094.1 - 0.019 15.1 1.2 0.019 15.1 1.2 5.8 5 1 0 5 5 5 0 Zinc ribbon domain zf-FLZ PF04570.14 PIK44094.1 - 3.5 7.2 8.6 0.39 10.2 0.2 3.3 4 0 0 4 4 4 0 zinc-finger of the FCS-type, C2-C2 zf-C2H2_jaz PF12171.8 PIK44094.1 - 3.7 8.0 28.7 0.33 11.3 1.0 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding 7tm_1 PF00001.21 PIK44095.1 - 5.1e-19 68.6 13.9 6.2e-19 68.3 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YkyA PF10368.9 PIK44096.1 - 0.034 13.8 2.1 0.068 12.8 0.5 1.9 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Lipase_GDSL PF00657.22 PIK44097.1 - 2.7e-13 50.3 0.0 7.9e-13 48.8 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK44097.1 - 2.4e-06 28.1 0.0 3.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK44098.1 - 6.2e-20 72.0 0.0 8.3e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK44098.1 - 9.8e-07 29.3 0.1 2.4e-06 28.0 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK44099.1 - 1.7e-17 64.1 0.0 2.3e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK44099.1 - 4.7e-09 36.9 0.0 2.5e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Radical_SAM PF04055.21 PIK44099.1 - 0.075 13.4 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily Ion_trans_2 PF07885.16 PIK44100.1 - 2.5e-21 75.4 12.5 8.2e-14 51.3 4.4 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 PIK44100.1 - 0.0038 16.5 3.9 0.0087 15.3 4.0 1.5 1 1 0 1 1 1 1 Ion transport protein LMF1 PF06762.14 PIK44100.1 - 0.042 12.9 0.1 0.051 12.7 0.1 1.1 1 0 0 1 1 1 0 Lipase maturation factor Sigma_reg_N PF13800.6 PIK44100.1 - 0.12 12.7 3.4 4.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF5379 PF17350.2 PIK44100.1 - 0.24 11.7 2.2 0.21 11.9 0.5 1.9 2 1 0 2 2 2 0 Family of unknown function (DUF5379) Sulfotransfer_3 PF13469.6 PIK44101.1 - 0.0049 17.3 0.0 0.0081 16.6 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family CcmE PF03100.15 PIK44101.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 CcmE Aminotran_5 PF00266.19 PIK44102.1 - 3.4e-22 78.9 0.0 4.6e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK44102.1 - 0.0037 16.5 0.0 0.0061 15.8 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II PPR_2 PF13041.6 PIK44103.1 - 6.6e-22 77.4 22.5 7e-08 32.5 0.0 12.1 11 2 3 14 14 14 5 PPR repeat family PPR PF01535.20 PIK44103.1 - 1.4e-20 72.0 22.2 0.0074 16.5 0.0 14.2 17 0 0 17 17 17 6 PPR repeat PPR_3 PF13812.6 PIK44103.1 - 1.9e-20 72.7 11.3 1.6e-06 28.1 0.1 8.9 9 1 2 11 11 11 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 PIK44103.1 - 2.9e-15 55.7 1.1 9.4e-06 25.2 0.0 7.3 8 0 0 8 8 8 3 PPR repeat PPR_long PF17177.4 PIK44103.1 - 3.8e-14 52.5 4.8 2.1e-05 24.0 0.1 7.0 6 1 1 7 7 7 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 PIK44103.1 - 3.2e-06 27.0 0.2 0.036 13.9 0.0 5.3 4 1 1 5 5 5 2 Mitochondrial ATPase expression DUF4936 PF16290.5 PIK44103.1 - 0.00011 22.8 0.3 0.0071 17.0 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4936) CCDC85 PF10226.9 PIK44104.1 - 2.5e-54 183.9 11.2 3.4e-54 183.5 11.2 1.2 1 0 0 1 1 1 1 CCDC85 family DUF5082 PF16888.5 PIK44104.1 - 0.098 12.9 6.3 7.5 6.8 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) DivIC PF04977.15 PIK44104.1 - 0.14 12.0 6.8 0.49 10.2 1.8 2.5 2 0 0 2 2 2 0 Septum formation initiator DivIVA PF05103.13 PIK44104.1 - 0.15 12.2 0.3 0.15 12.2 0.3 2.2 2 0 0 2 2 2 0 DivIVA protein AMH_N PF04709.12 PIK44104.1 - 0.29 10.0 4.4 0.38 9.6 0.7 2.1 2 0 0 2 2 2 0 Anti-Mullerian hormone, N terminal region YabA PF06156.13 PIK44104.1 - 0.44 11.2 9.0 1.1 9.9 2.2 2.5 1 1 1 2 2 2 0 Initiation control protein YabA BRE1 PF08647.11 PIK44104.1 - 0.49 10.5 9.9 1.3 9.1 1.0 2.9 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase ATG11 PF10377.9 PIK44104.1 - 0.56 10.3 2.7 0.7 10.0 0.3 2.0 1 1 1 2 2 2 0 Autophagy-related protein 11 YkyA PF10368.9 PIK44104.1 - 0.8 9.3 8.5 1.5 8.5 1.2 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein bZIP_1 PF00170.21 PIK44104.1 - 1.3 9.2 15.4 2.4 8.3 3.2 3.9 3 1 1 4 4 4 0 bZIP transcription factor EMC3_TMCO1 PF01956.16 PIK44104.1 - 1.3 8.7 3.1 11 5.7 0.4 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CENP-H PF05837.12 PIK44104.1 - 2.9 8.3 8.4 2 8.9 0.7 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Exonuc_VII_L PF02601.15 PIK44104.1 - 3.1 7.3 5.5 3.7 7.0 4.8 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Shugoshin_N PF07558.11 PIK44104.1 - 3.2 7.7 7.1 0.19 11.7 1.6 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region ZapB PF06005.12 PIK44104.1 - 3.2 8.2 10.0 2.4 8.6 0.4 3.1 3 1 0 3 3 3 0 Cell division protein ZapB Sec34 PF04136.15 PIK44104.1 - 3.2 7.6 8.2 3 7.7 0.7 2.4 1 1 1 2 2 2 0 Sec34-like family TSC22 PF01166.18 PIK44104.1 - 5.6 7.3 10.9 0.33 11.3 2.5 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family IPK PF03770.16 PIK44105.1 - 9.8e-39 133.3 1.1 2.4e-38 132.0 1.1 1.7 1 1 0 1 1 1 1 Inositol polyphosphate kinase Zeta_toxin PF06414.12 PIK44105.1 - 0.017 14.4 0.1 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin DUF2448 PF10476.9 PIK44106.1 - 0.1 12.5 0.9 0.21 11.5 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Na_trans_assoc PF06512.13 PIK44106.1 - 5.2 7.3 9.6 0.88 9.8 5.6 1.8 2 0 0 2 2 2 0 Sodium ion transport-associated Sulfotransfer_3 PF13469.6 PIK44107.1 - 1.3e-08 35.6 0.1 3.4e-07 30.9 0.1 2.3 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK44107.1 - 2.7e-05 23.8 0.4 6.8e-05 22.5 0.4 1.6 1 1 0 1 1 1 1 Sulfotransferase domain DUF3390 PF11870.8 PIK44107.1 - 0.078 13.4 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3390) Pkinase PF00069.25 PIK44108.1 - 5.2e-10 39.1 0.1 9.8e-06 25.1 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44108.1 - 0.0018 17.6 0.3 0.012 14.9 0.3 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase CPBP PF02517.16 PIK44109.1 - 8.8e-18 64.5 4.6 8.8e-18 64.5 4.6 2.2 3 0 0 3 3 3 1 CPBP intramembrane metalloprotease FAM181 PF15238.6 PIK44110.1 - 1.3e-09 38.4 0.9 1.9e-09 37.8 0.9 1.4 1 0 0 1 1 1 1 FAM181 Pox_A12 PF04651.13 PIK44110.1 - 0.1 12.6 0.2 0.17 12.0 0.2 1.3 1 0 0 1 1 1 0 Poxvirus A12 protein bZIP_2 PF07716.15 PIK44111.1 - 4e-13 49.2 13.6 4e-13 49.2 13.6 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK44111.1 - 4.4e-08 33.1 9.4 4.4e-08 33.1 9.4 1.8 2 0 0 2 2 2 1 bZIP transcription factor HALZ PF02183.18 PIK44111.1 - 0.042 14.1 0.5 0.096 12.9 0.5 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_Maf PF03131.17 PIK44111.1 - 0.13 12.8 7.3 0.33 11.5 7.3 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF2340 PF10209.9 PIK44112.1 - 0.063 13.7 0.8 0.22 12.0 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2340) Ribosom_S12_S23 PF00164.25 PIK44113.1 - 5.6e-29 100.1 2.7 7.2e-29 99.7 2.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF4513 PF14983.6 PIK44114.1 - 2.6e-15 56.7 0.0 3.2e-15 56.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4513) Ribosomal_S20p PF01649.18 PIK44115.1 - 0.14 12.8 2.8 0.69 10.6 2.8 2.3 1 0 0 1 1 1 0 Ribosomal protein S20 Presenilin PF01080.17 PIK44116.1 - 1.2e-145 485.3 4.2 1.2e-145 485.3 4.2 2.2 2 1 0 2 2 2 1 Presenilin Acyl_transf_3 PF01757.22 PIK44116.1 - 5.9e-05 22.3 11.3 5.9e-05 22.3 11.3 2.1 2 0 0 2 2 2 1 Acyltransferase family Orf78 PF06024.12 PIK44116.1 - 1.5 9.2 9.7 3.1 8.2 0.0 3.8 2 1 1 3 3 3 0 Orf78 (ac78) SSF PF00474.17 PIK44117.1 - 7.1e-35 120.6 25.7 2.5e-34 118.8 25.7 1.8 1 1 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK44119.1 - 8.2e-10 38.1 5.6 1.2e-09 37.5 0.5 2.1 1 1 1 2 2 2 2 Sodium:solute symporter family Homeodomain PF00046.29 PIK44120.1 - 2.4e-19 68.9 2.7 4.8e-19 68.0 2.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 PIK44121.1 - 9.8e-22 76.6 4.6 1.3e-21 76.2 4.6 1.1 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 PIK44121.1 - 0.18 11.3 0.2 0.29 10.6 0.2 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 PIK44122.1 - 6e-21 74.0 5.1 9.9e-21 73.4 5.1 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK44122.1 - 0.019 14.8 0.3 0.019 14.8 0.3 2.5 4 0 0 4 4 4 0 Homeobox KN domain Homez PF11569.8 PIK44122.1 - 0.41 10.2 3.5 0.33 10.4 0.2 2.2 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez zf-C4 PF00105.18 PIK44123.1 - 2.6e-27 95.0 13.2 2.6e-27 95.0 13.2 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK44123.1 - 0.00019 21.1 0.0 0.00068 19.3 0.0 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Slu7 PF11708.8 PIK44124.1 - 1.4e-106 356.2 12.7 1.4e-106 356.2 12.7 2.2 2 0 0 2 2 2 2 Pre-mRNA splicing Prp18-interacting factor Cwf_Cwc_15 PF04889.12 PIK44124.1 - 0.56 9.9 34.3 0.063 13.0 23.5 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein LMBR1 PF04791.16 PIK44124.1 - 3.2 6.6 4.2 5 5.9 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Vfa1 PF08432.10 PIK44124.1 - 3.9 7.8 33.7 0.053 13.9 18.7 3.0 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 PIK44124.1 - 5 7.2 10.4 1.5 8.9 6.4 2.1 2 0 0 2 2 2 0 DDHD domain C1-set PF07654.15 PIK44125.1 - 1.2e-05 25.5 4.6 2.4e-05 24.6 4.6 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK44125.1 - 0.00052 20.0 1.8 0.00084 19.4 1.8 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF1857 PF08982.11 PIK44125.1 - 0.0057 16.5 0.1 0.014 15.3 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF1857) Ig_3 PF13927.6 PIK44125.1 - 0.015 15.9 3.2 0.049 14.2 3.4 1.9 1 1 1 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK44125.1 - 0.045 13.9 6.0 0.034 14.3 3.9 1.9 2 1 0 2 2 2 0 Immunoglobulin domain MtrG PF04210.13 PIK44126.1 - 0.069 13.0 0.2 0.14 12.0 0.1 1.5 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Ig_3 PF13927.6 PIK44127.1 - 0.043 14.4 0.2 0.18 12.4 0.1 2.1 1 1 1 2 2 2 0 Immunoglobulin domain Got1 PF04178.12 PIK44127.1 - 0.047 14.1 0.7 0.09 13.2 0.7 1.4 1 0 0 1 1 1 0 Got1/Sft2-like family C2-set_2 PF08205.12 PIK44127.1 - 0.078 13.1 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain SDA1 PF05285.12 PIK44127.1 - 0.86 9.0 64.8 1.4 8.3 64.8 1.2 1 0 0 1 1 1 0 SDA1 OpcA_G6PD_assem PF10128.9 PIK44128.1 - 0.11 12.0 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit NACHT PF05729.12 PIK44129.1 - 2.8e-05 24.1 0.0 4.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK44129.1 - 0.0018 18.6 0.0 0.0034 17.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 PIK44129.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 PIK44129.1 - 0.019 15.4 0.0 0.028 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ig PF00047.25 PIK44129.1 - 0.025 14.8 0.3 0.057 13.6 0.3 1.6 1 1 0 1 1 1 0 Immunoglobulin domain AAA_7 PF12775.7 PIK44129.1 - 0.041 13.4 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Ig_3 PF13927.6 PIK44129.1 - 0.054 14.1 0.2 0.14 12.7 0.2 1.7 1 1 0 1 1 1 0 Immunoglobulin domain TsaE PF02367.17 PIK44129.1 - 0.06 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 PIK44129.1 - 0.068 13.7 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter I-set PF07679.16 PIK44129.1 - 0.11 12.6 0.1 0.4 10.8 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin I-set domain RVT_1 PF00078.27 PIK44130.1 - 6.7e-31 107.5 0.3 1.9e-30 106.1 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44130.1 - 0.02 14.9 0.0 0.048 13.7 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase V-set PF07686.17 PIK44131.1 - 4.6e-08 33.2 0.2 1.4e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK44131.1 - 3.6e-06 27.0 0.1 6e-05 23.0 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK44131.1 - 5.8e-06 26.8 0.9 6.9e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK44131.1 - 5.8e-06 26.4 1.3 0.00026 21.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain MULE PF10551.9 PIK44132.1 - 7.8e-12 45.5 0.0 1.5e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Exotox-A_target PF09102.10 PIK44133.1 - 0.041 13.9 1.0 0.86 9.6 0.4 2.3 1 1 1 2 2 2 0 Exotoxin A, targeting FLYWCH_u PF16662.5 PIK44135.1 - 0.15 12.1 0.2 13 5.9 0.1 2.7 2 1 0 2 2 2 0 FLYWCH-type zinc finger-containing protein 1 HYR PF02494.16 PIK44136.1 - 9.5e-46 154.0 8.3 1.5e-22 79.7 0.8 2.5 2 0 0 2 2 2 2 HYR domain HYR PF02494.16 PIK44137.1 - 3.2e-12 46.6 4.3 3.2e-12 46.6 4.3 3.3 2 1 1 3 3 3 3 HYR domain Big_7 PF17957.1 PIK44137.1 - 0.12 13.2 0.2 0.12 13.2 0.2 3.3 1 1 2 3 3 3 0 Bacterial Ig domain Metallothio_Cad PF07846.11 PIK44137.1 - 2.1 8.5 13.7 3.3 7.9 0.7 3.8 3 0 0 3 3 3 0 Metallothionein family 7tm_2 PF00002.24 PIK44138.1 - 2.6e-07 30.2 1.2 3.2e-07 29.9 1.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) WD40 PF00400.32 PIK44139.1 - 2.1e-30 104.3 7.6 4.9e-07 30.4 0.8 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44139.1 - 1.4e-25 89.4 0.4 0.0024 18.1 0.0 6.8 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK44139.1 - 3.1e-11 43.5 0.1 3.3e-06 27.1 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK44139.1 - 9.5e-09 34.8 0.8 0.00051 19.2 0.4 3.1 1 1 1 3 3 3 3 Coatomer WD associated region PD40 PF07676.12 PIK44139.1 - 1.1e-05 25.3 0.0 0.0048 16.8 0.0 3.7 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 PIK44139.1 - 2e-05 22.8 0.5 0.00034 18.8 0.1 2.2 1 1 1 2 2 2 2 IKI3 family Cytochrom_D1 PF02239.16 PIK44139.1 - 0.00054 18.6 0.0 0.19 10.2 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain WDCP PF15390.6 PIK44139.1 - 0.0017 16.8 1.5 0.0034 15.8 0.4 1.8 2 0 0 2 2 2 1 WD repeat and coiled-coil-containing protein family RAB3GAP2_N PF14655.6 PIK44139.1 - 0.066 12.5 0.0 6.4 5.9 0.0 2.6 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF5397 PF17375.2 PIK44139.1 - 0.2 11.4 0.3 0.58 9.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5397) Zn-C2H2_12 PF18112.1 PIK44140.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain UIM PF02809.20 PIK44141.1 - 0.0046 16.8 3.2 0.0046 16.8 3.2 3.8 3 0 0 3 3 3 1 Ubiquitin interaction motif WD40 PF00400.32 PIK44142.1 - 7.8e-36 121.5 20.7 4.4e-08 33.7 0.1 11.4 10 1 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44142.1 - 2.7e-26 91.7 0.5 0.0013 19.0 0.0 8.2 3 3 5 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK44142.1 - 3.3e-09 36.9 0.1 0.2 11.5 0.1 4.8 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK44142.1 - 1.7e-08 33.8 1.6 0.26 10.2 0.0 5.0 4 2 2 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 PIK44142.1 - 6e-06 26.0 0.4 1 9.4 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 PIK44142.1 - 0.011 15.0 0.4 0.86 8.9 0.0 3.8 3 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal HPS3_N PF14761.6 PIK44142.1 - 0.014 14.9 0.0 5.5 6.5 0.0 2.7 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 DUF839 PF05787.13 PIK44142.1 - 0.036 13.2 0.1 0.21 10.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF839) GspH PF12019.8 PIK44142.1 - 0.053 13.9 0.0 1.8 9.0 0.0 2.8 2 1 0 2 2 2 0 Type II transport protein GspH Kelch_6 PF13964.6 PIK44142.1 - 0.058 13.7 2.4 20 5.6 0.0 4.0 5 0 0 5 5 4 0 Kelch motif Nup160 PF11715.8 PIK44142.1 - 0.16 10.6 0.0 3.8 6.0 0.0 2.4 2 0 0 2 2 2 0 Nucleoporin Nup120/160 VID27 PF08553.10 PIK44142.1 - 0.17 10.9 0.1 4.4 6.2 0.0 2.5 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain PQQ PF01011.21 PIK44142.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.5 4 0 0 4 4 4 0 PQQ enzyme repeat zf-C2H2_4 PF13894.6 PIK44143.1 - 2.7e-11 43.3 29.6 0.03 15.1 0.1 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK44143.1 - 2.7e-10 40.1 34.0 0.075 13.5 1.0 7.3 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK44143.1 - 2.7e-05 23.8 29.0 0.034 13.9 1.2 6.2 6 0 0 6 6 6 3 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK44143.1 - 0.0048 17.3 42.4 0.15 12.6 1.2 8.5 9 1 0 9 9 8 3 Zinc-finger double domain zf-C2H2_2 PF12756.7 PIK44143.1 - 0.013 15.8 34.7 0.042 14.2 2.9 6.6 2 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 PIK44143.1 - 0.015 14.9 34.3 0.3 10.8 0.6 7.1 4 3 3 7 7 7 0 Zinc-fingers and homeoboxes C2H2 finger domain RNHCP PF12647.7 PIK44143.1 - 0.028 14.4 2.4 0.028 14.4 2.4 4.9 3 2 1 4 4 4 0 RNHCP domain OrfB_Zn_ribbon PF07282.11 PIK44143.1 - 0.034 14.1 0.3 0.034 14.1 0.3 5.0 4 1 1 5 5 5 0 Putative transposase DNA-binding domain zf-C2HE PF16278.5 PIK44143.1 - 0.035 14.6 2.8 0.035 14.6 2.8 5.5 3 2 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-ACC PF17848.1 PIK44143.1 - 0.39 10.8 0.0 0.39 10.8 0.0 4.3 6 0 0 6 6 4 0 Acetyl-coA carboxylase zinc finger domain zn-ribbon_14 PF16503.5 PIK44143.1 - 0.56 9.8 0.1 0.56 9.8 0.1 5.2 7 0 0 7 7 7 0 Zinc-ribbon zf-C2H2_11 PF16622.5 PIK44143.1 - 1.1 9.0 0.0 0.54 10.1 0.9 6.5 8 0 0 8 8 8 0 zinc-finger C2H2-type YokU PF14122.6 PIK44143.1 - 1.2 9.2 11.3 7.8 6.6 0.1 4.5 3 2 1 4 4 4 0 YokU-like protein, putative antitoxin zf-C2H2_jaz PF12171.8 PIK44143.1 - 2 8.8 22.0 13 6.3 0.6 6.4 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding RNA_POL_M_15KD PF02150.16 PIK44143.1 - 2.9 7.8 18.0 0.69 9.8 0.2 5.6 7 0 0 7 7 7 0 RNA polymerases M/15 Kd subunit zf-MYST PF17772.1 PIK44143.1 - 3.1 7.5 12.7 2.3 7.9 0.7 4.5 5 1 0 5 5 5 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 PIK44143.1 - 5.6 7.8 24.4 0.59 10.9 1.5 4.2 2 2 2 4 4 4 0 zinc-ribbon family Rubredoxin_2 PF18073.1 PIK44143.1 - 9.6 6.0 26.2 19 5.1 0.0 6.7 7 0 0 7 7 7 0 Rubredoxin metal binding domain RabGAP-TBC PF00566.18 PIK44144.1 - 7.4e-50 169.6 0.1 1.2e-49 168.9 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AAA PF00004.29 PIK44146.1 - 1.7e-37 128.8 0.0 3.3e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK44146.1 - 1.4e-08 34.3 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 PIK44146.1 - 0.00066 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK44146.1 - 0.0012 18.8 0.0 0.0058 16.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK44146.1 - 0.0014 18.9 0.8 0.069 13.4 0.2 2.7 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK44146.1 - 0.0029 17.8 0.0 0.0088 16.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 PIK44146.1 - 0.0048 17.3 0.5 0.026 14.9 0.5 2.1 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 PIK44146.1 - 0.057 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 PIK44146.1 - 0.081 12.3 0.1 0.19 11.1 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI BBIP10 PF14777.6 PIK44147.1 - 8.9e-31 105.3 6.8 1.1e-30 105.0 6.8 1.0 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 DUF2098 PF09871.9 PIK44147.1 - 0.021 15.1 0.1 0.023 15.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) FAM178 PF14816.6 PIK44148.1 - 1.8e-28 99.6 0.6 3.9e-28 98.5 0.0 1.9 2 0 0 2 2 2 1 Family of unknown function, FAM178 FYVE PF01363.21 PIK44149.1 - 2.7e-21 75.5 9.2 2.7e-21 75.5 9.2 2.1 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 PIK44149.1 - 0.0016 18.6 6.0 0.0016 18.6 6.0 1.7 2 0 0 2 2 2 1 FYVE-type zinc finger IBR PF01485.21 PIK44149.1 - 0.52 10.6 10.1 0.082 13.1 4.6 2.2 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Zn-ribbon_8 PF09723.10 PIK44149.1 - 3.6 7.8 8.8 2 8.6 2.2 2.7 1 1 1 2 2 2 0 Zinc ribbon domain DUF1230 PF06799.11 PIK44150.1 - 0.022 14.9 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Conserved in the green lineage and diatoms 27 Pentapeptide_4 PF13599.6 PIK44151.1 - 1.2e-09 38.2 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 PIK44151.1 - 5.8e-08 32.2 0.0 0.0074 15.9 0.0 2.2 1 1 0 2 2 2 2 Pentapeptide repeats (8 copies) gag-asp_proteas PF13975.6 PIK44151.1 - 0.0085 16.6 2.0 1.5 9.4 2.0 2.5 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Thia_YuaJ PF09515.10 PIK44151.1 - 0.086 12.9 0.2 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) Amino_oxidase PF01593.24 PIK44152.1 - 6.5e-11 42.2 0.9 9.1e-10 38.4 0.9 2.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK44152.1 - 1.9e-09 37.6 0.1 5.5e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 PIK44152.1 - 1.5e-06 27.7 0.1 0.0047 16.2 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK44152.1 - 2.6e-06 26.9 0.2 2.5e-05 23.7 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 PIK44152.1 - 1.1e-05 24.8 0.1 5.1e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 PIK44152.1 - 1.5e-05 24.8 3.1 0.00079 19.1 3.2 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK44152.1 - 3.6e-05 23.0 6.8 0.0029 16.7 1.7 2.5 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 PIK44152.1 - 4.1e-05 23.1 0.0 0.00041 19.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK44152.1 - 0.00026 20.2 2.5 0.063 12.4 0.9 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A GDI PF00996.18 PIK44152.1 - 0.00027 19.6 0.1 0.11 11.0 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Pyr_redox PF00070.27 PIK44152.1 - 0.0047 17.5 1.6 3.9 8.1 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK44152.1 - 0.018 13.8 1.1 0.03 13.0 0.3 1.7 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 PIK44152.1 - 0.043 13.1 0.7 0.075 12.3 0.7 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 PIK44152.1 - 0.24 10.2 0.6 1.2 7.9 0.2 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Ribosomal_L26 PF16906.5 PIK44153.1 - 1.9e-40 137.2 5.0 2.6e-40 136.7 5.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 PIK44153.1 - 8.7e-07 28.7 7.0 8.7e-07 28.7 7.0 2.5 2 1 0 2 2 2 1 KOW motif DarT PF14487.6 PIK44153.1 - 0.071 12.9 0.3 0.095 12.5 0.3 1.1 1 0 0 1 1 1 0 ssDNA thymidine ADP-ribosyltransferase, DarT Acyl-CoA_dh_N PF02771.16 PIK44154.1 - 3.4e-26 92.1 0.0 4.6e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK44154.1 - 1.2e-12 47.8 0.0 2.1e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Ig_3 PF13927.6 PIK44155.1 - 1.3e-08 35.3 0.2 6e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK44155.1 - 0.0013 19.0 2.1 0.12 12.7 0.1 3.1 3 1 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK44155.1 - 0.0018 18.4 0.7 0.15 12.3 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK44155.1 - 0.0043 17.2 0.1 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK44155.1 - 0.04 14.0 0.0 0.46 10.6 0.0 2.3 2 1 0 2 2 2 0 Immunoglobulin I-set domain Pkinase_Tyr PF07714.17 PIK44156.1 - 3.6e-25 88.7 0.0 7.5e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44156.1 - 6.2e-11 42.1 0.0 1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK44156.1 - 0.00081 19.9 0.3 2.6 8.7 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK44156.1 - 0.0073 16.4 0.1 0.19 11.8 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_4 PF16680.5 PIK44156.1 - 0.016 15.5 2.0 0.03 14.6 0.1 2.6 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain ig PF00047.25 PIK44156.1 - 0.033 14.3 0.8 12 6.2 0.1 3.2 4 0 0 4 4 4 0 Immunoglobulin domain Ig_2 PF13895.6 PIK44156.1 - 0.21 11.9 1.2 2.6 8.4 0.1 2.7 3 0 0 3 3 3 0 Immunoglobulin domain V-set PF07686.17 PIK44157.1 - 5e-07 29.9 2.0 2.7e-05 24.3 0.1 3.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK44157.1 - 8e-06 26.4 2.6 0.24 12.0 0.1 4.5 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK44157.1 - 1.1e-05 25.4 0.1 0.071 13.2 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DUF768 PF05589.11 PIK44157.1 - 0.28 11.2 1.2 40 4.3 0.0 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF768) C2-set_2 PF08205.12 PIK44158.1 - 0.00019 21.4 0.2 0.0037 17.3 0.0 2.6 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain BatD PF13584.6 PIK44158.1 - 0.0084 15.0 0.0 3 6.6 0.0 2.7 3 0 0 3 3 3 2 Oxygen tolerance Ig_3 PF13927.6 PIK44158.1 - 0.058 14.0 9.0 0.81 10.3 0.2 4.5 4 3 2 6 6 6 0 Immunoglobulin domain Trp_oprn_chp PF09534.10 PIK44158.1 - 0.14 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ig PF00047.25 PIK44158.1 - 0.32 11.2 2.7 2 8.7 0.1 3.3 5 0 0 5 5 5 0 Immunoglobulin domain MA3 PF02847.17 PIK44159.1 - 0.25 11.3 7.6 4.5 7.3 1.0 3.4 3 1 1 4 4 4 0 MA3 domain Popeye PF04831.13 PIK44159.1 - 1.2 9.3 5.4 0.51 10.5 0.2 2.4 2 1 0 2 2 2 0 Popeye protein conserved region Ig_3 PF13927.6 PIK44160.1 - 5.4e-12 46.1 0.1 5.6e-05 23.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK44160.1 - 2.4e-08 34.0 2.3 1.3e-05 25.2 0.3 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK44160.1 - 5.2e-06 26.4 0.1 0.041 13.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK44160.1 - 2.4e-05 24.6 1.8 0.093 13.1 0.3 2.6 1 1 1 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 PIK44160.1 - 0.00015 21.3 0.0 0.36 10.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK44160.1 - 0.00032 20.9 2.1 0.06 13.5 0.2 2.8 2 2 0 2 2 2 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK44160.1 - 0.0021 18.1 0.0 2 8.5 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK44160.1 - 0.036 14.3 1.2 8.5 6.7 0.1 3.0 2 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain CARDB PF07705.11 PIK44161.1 - 5.7e-13 49.0 11.4 5.6e-11 42.6 0.3 4.2 4 0 0 4 4 4 3 CARDB CARDB PF07705.11 PIK44162.1 - 4.5e-14 52.5 0.7 5.5e-10 39.4 0.0 4.9 4 0 0 4 4 4 1 CARDB RHS_repeat PF05593.14 PIK44162.1 - 0.00032 21.1 26.7 0.0054 17.2 2.5 6.8 4 1 3 7 7 7 3 RHS Repeat DUF4832 PF16116.5 PIK44162.1 - 0.017 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4832) DUF4412 PF14371.6 PIK44162.1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4412) 7tm_1 PF00001.21 PIK44163.1 - 1.3e-23 83.7 9.6 1.6e-23 83.4 9.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK44163.1 - 2.4e-07 30.6 12.1 3.1e-07 30.3 12.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK44163.1 - 3.8e-05 23.2 4.9 5e-05 22.8 4.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK44163.1 - 7.6e-05 22.2 8.0 0.00011 21.7 8.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0542 PF15086.6 PIK44163.1 - 0.17 11.8 0.1 0.17 11.8 0.1 2.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 Frag1 PF10277.9 PIK44163.1 - 0.18 11.3 10.3 2.3 7.7 0.3 2.4 2 1 0 2 2 2 0 Frag1/DRAM/Sfk1 family VWD PF00094.25 PIK44164.1 - 1.3e-80 269.2 17.3 7.7e-35 120.5 1.9 4.8 4 0 0 4 4 4 3 von Willebrand factor type D domain C8 PF08742.11 PIK44164.1 - 1.4e-46 156.8 35.8 3.6e-18 65.7 9.6 7.5 7 0 0 7 7 7 3 C8 domain TIL PF01826.17 PIK44164.1 - 6.3e-25 87.2 81.6 7.1e-10 39.0 18.5 12.7 12 1 0 12 12 12 4 Trypsin Inhibitor like cysteine rich domain Ldl_recept_a PF00057.18 PIK44164.1 - 6.8e-25 87.0 67.5 1.9e-09 37.6 9.9 11.7 11 0 0 11 11 11 5 Low-density lipoprotein receptor domain class A VWC PF00093.18 PIK44164.1 - 0.00056 20.2 5.9 0.00056 20.2 5.9 12.4 10 3 3 13 13 13 4 von Willebrand factor type C domain Pacifastin_I PF05375.13 PIK44164.1 - 0.00061 19.5 10.1 0.00061 19.5 10.1 8.4 9 0 0 9 9 9 2 Pacifastin inhibitor (LCMII) Ldl_recept_a PF00057.18 PIK44165.1 - 1.1e-06 28.7 5.4 1.8e-06 28.1 5.4 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.19 PIK44166.1 - 7.5e-25 86.9 34.0 4.4e-13 49.2 8.4 6.2 6 0 0 6 6 6 3 Thrombospondin type 1 domain F5_F8_type_C PF00754.25 PIK44166.1 - 4e-14 52.8 0.0 2.2e-13 50.5 0.0 2.4 2 0 0 2 2 2 1 F5/8 type C domain TIL PF01826.17 PIK44166.1 - 1.3e-09 38.2 20.4 1.3e-09 38.2 20.4 9.0 5 3 4 9 9 9 2 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 PIK44166.1 - 2.4e-07 30.9 13.8 2.4e-07 30.9 13.8 7.9 5 1 0 6 6 6 2 von Willebrand factor type C domain Utp11 PF03998.13 PIK44167.1 - 2.6e-66 224.0 27.9 3e-66 223.9 27.9 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 PIK44167.1 - 0.042 13.2 2.3 0.078 12.3 0.2 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 CRM1_C PF08767.11 PIK44168.1 - 0.042 13.0 0.0 0.042 13.0 0.0 2.7 3 0 0 3 3 3 0 CRM1 C terminal SRCR PF00530.18 PIK44169.1 - 2.3e-68 227.0 29.5 4.2e-29 101.0 4.7 4.8 2 1 1 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44169.1 - 5.5e-15 55.7 5.3 5.4e-06 26.9 0.4 3.5 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44169.1 - 5.7e-06 26.8 0.0 0.17 12.4 0.0 2.7 2 0 0 2 2 2 2 Hepsin, SRCR domain Pectate_lyase_3 PF12708.7 PIK44169.1 - 0.035 13.9 2.6 1.1 9.0 0.3 2.8 1 1 2 3 3 3 0 Pectate lyase superfamily protein TcfC PF16967.5 PIK44169.1 - 0.097 12.2 0.7 0.95 9.0 0.2 2.6 2 1 0 2 2 2 0 E-set like domain SRCR PF00530.18 PIK44170.1 - 3.5e-31 107.7 2.5 4e-31 107.5 2.5 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44170.1 - 5.7e-07 30.0 0.4 9e-07 29.4 0.2 1.3 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44170.1 - 0.0077 16.7 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Hepsin, SRCR domain SRCR PF00530.18 PIK44171.1 - 1.2e-21 77.1 0.2 1.4e-21 76.8 0.2 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44171.1 - 3e-07 30.9 0.5 4.1e-07 30.4 0.5 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44171.1 - 0.023 15.2 0.0 0.03 14.8 0.0 1.2 1 0 0 1 1 1 0 Hepsin, SRCR domain DUF5370 PF17340.2 PIK44171.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5370) SRCR PF00530.18 PIK44172.1 - 3.2e-72 239.4 20.3 6.5e-31 106.8 5.0 3.0 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44172.1 - 1.1e-14 54.8 2.7 2.4e-06 28.0 0.5 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44172.1 - 2.9e-06 27.8 0.0 0.12 12.9 0.0 2.5 2 0 0 2 2 2 2 Hepsin, SRCR domain TcfC PF16967.5 PIK44172.1 - 0.23 11.0 0.1 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 E-set like domain SRCR PF00530.18 PIK44173.1 - 2.4e-288 932.9 108.5 8.3e-30 103.2 4.9 10.0 10 0 0 10 10 10 10 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44173.1 - 3.7e-65 216.6 53.6 7.1e-06 26.5 0.5 10.6 10 0 0 10 10 10 10 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44173.1 - 1.7e-31 109.0 0.5 0.44 11.1 0.0 10.7 10 0 0 10 10 10 10 Hepsin, SRCR domain DUF333 PF03891.15 PIK44173.1 - 3.1e-07 30.5 0.6 2.2e+02 2.2 0.0 9.5 10 0 0 10 10 10 0 Domain of unknown function (DUF333) TcfC PF16967.5 PIK44173.1 - 5.5e-05 22.6 12.0 48 3.5 0.0 9.3 10 0 0 10 10 10 0 E-set like domain phage_tail_N PF08400.10 PIK44173.1 - 0.014 15.4 9.3 51 3.8 0.0 7.5 9 0 0 9 9 9 0 Prophage tail fibre N-terminal REGB_T4 PF10715.9 PIK44173.1 - 0.062 13.5 9.7 48 4.1 0.1 6.5 7 0 0 7 7 7 0 T4-page Endoribonuclease RegB SRCR PF00530.18 PIK44174.1 - 6e-221 716.6 75.5 7.8e-31 106.5 3.8 9.1 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44174.1 - 3.8e-60 200.5 34.3 1.3e-06 28.9 0.1 9.5 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44174.1 - 1.7e-25 89.6 1.6 0.32 11.5 0.0 9.4 9 0 0 9 9 9 7 Hepsin, SRCR domain Fibrinogen_C PF00147.18 PIK44174.1 - 4.7e-21 75.6 4.4 2e-20 73.5 4.4 2.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF333 PF03891.15 PIK44174.1 - 0.00015 21.9 3.8 1.2e+02 3.0 0.0 7.7 9 0 0 9 9 9 0 Domain of unknown function (DUF333) TcfC PF16967.5 PIK44174.1 - 0.00073 19.0 0.6 13 5.3 0.0 5.7 7 0 0 7 7 7 1 E-set like domain Prot_ATP_OB_N PF17758.1 PIK44174.1 - 0.13 11.9 8.6 96 2.7 0.0 7.7 11 0 0 11 11 11 0 Proteasomal ATPase OB N-terminal domain CreA PF05981.12 PIK44174.1 - 0.53 10.3 5.1 83 3.2 0.0 5.8 8 0 0 8 8 8 0 CreA protein DUF4601 PF15373.6 PIK44175.1 - 7.7e-19 68.0 10.4 1.1e-18 67.5 10.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4601) PH PF00169.29 PIK44176.1 - 8.4e-07 29.5 0.4 2.6e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 PH domain CCD48 PF15799.5 PIK44176.1 - 0.0039 15.6 3.7 0.0088 14.4 3.7 1.5 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 48 PH_11 PF15413.6 PIK44176.1 - 0.0069 16.8 0.1 0.0069 16.8 0.1 2.7 3 1 0 3 3 3 1 Pleckstrin homology domain START PF01852.19 PIK44176.1 - 0.042 13.2 0.9 0.12 11.7 0.1 2.0 2 0 0 2 2 2 0 START domain PH_8 PF15409.6 PIK44176.1 - 0.063 13.6 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4541 PF15074.6 PIK44176.1 - 0.92 10.2 4.9 14 6.3 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4541) DuoxA PF10204.9 PIK44177.1 - 8.9e-75 251.3 3.3 1.1e-74 250.9 3.3 1.1 1 0 0 1 1 1 1 Dual oxidase maturation factor An_peroxidase PF03098.15 PIK44178.1 - 6.2e-131 437.6 0.0 1.1e-130 436.8 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.12 PIK44178.1 - 9e-30 103.9 0.0 1.7e-29 103.0 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 PIK44178.1 - 8.2e-16 58.1 0.0 2.2e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 PIK44178.1 - 2.5e-13 50.2 15.9 5.2e-13 49.2 15.9 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_1 PF00036.32 PIK44178.1 - 1.3e-10 40.0 14.8 8.7e-07 28.1 0.4 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 PIK44178.1 - 4.1e-09 35.6 6.8 7.2e-05 22.4 0.6 4.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 PIK44178.1 - 8.2e-08 32.6 13.3 3e-05 24.4 2.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK44178.1 - 1.7e-06 27.2 13.1 0.00065 19.1 0.1 3.7 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 PIK44178.1 - 0.00013 21.7 12.5 0.08 12.8 0.1 3.9 3 1 0 3 3 3 2 EF-hand domain pair NAD_binding_1 PF00175.21 PIK44178.1 - 0.00034 21.2 0.0 0.013 16.1 0.0 2.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain EF-hand_4 PF12763.7 PIK44178.1 - 0.25 11.3 2.5 0.88 9.6 0.3 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ski_Sno PF02437.17 PIK44179.1 - 4e-34 116.6 0.3 9.5e-34 115.4 0.3 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 PIK44179.1 - 1.1e-33 115.3 2.0 1.1e-33 115.3 2.0 2.1 2 0 0 2 2 2 1 c-SKI Smad4 binding domain MF_alpha PF04648.12 PIK44179.1 - 0.043 14.1 0.2 0.1 12.9 0.2 1.7 1 0 0 1 1 1 0 Yeast mating factor alpha hormone Ank_5 PF13857.6 PIK44180.1 - 9.2e-24 83.2 0.7 2.1e-09 37.4 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK44180.1 - 4.3e-23 81.4 0.4 4.5e-12 46.2 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK44180.1 - 1.4e-19 70.5 0.1 2.1e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK44180.1 - 2.4e-15 56.2 0.2 7.2e-06 26.2 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 PIK44180.1 - 2.1e-11 43.0 0.0 0.032 14.8 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat 7tm_1 PF00001.21 PIK44181.1 - 1.7e-12 47.3 0.1 2.6e-12 46.7 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK44181.1 - 0.0089 15.4 0.3 0.012 15.0 0.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srt PF10321.9 PIK44181.1 - 0.02 13.9 0.6 0.029 13.4 0.6 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srt Coatomer_E PF04733.14 PIK44182.1 - 1.4e-103 346.3 6.1 1.6e-103 346.1 6.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 PIK44182.1 - 5.1e-10 39.7 8.2 5e-06 26.9 0.9 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK44182.1 - 1e-08 35.3 1.6 0.00082 20.0 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK44182.1 - 1.8e-07 31.3 4.7 0.0077 16.4 0.2 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 PIK44182.1 - 3.1e-07 30.6 3.7 4.4e-05 23.7 0.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK44182.1 - 8.9e-07 28.6 5.1 0.0008 19.3 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK44182.1 - 1.9e-06 27.4 3.5 0.0018 18.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK44182.1 - 5e-06 27.1 1.7 0.00031 21.3 0.1 3.2 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK44182.1 - 2.8e-05 23.7 1.1 0.00024 20.7 0.2 2.6 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 PIK44182.1 - 0.00021 21.3 4.9 0.22 11.8 0.1 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK44182.1 - 0.00026 20.8 3.1 0.034 14.2 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK44182.1 - 0.007 16.7 0.4 14 6.3 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK44182.1 - 0.027 13.9 1.9 0.39 10.0 0.2 2.2 1 1 1 2 2 2 0 MalT-like TPR region PPR PF01535.20 PIK44182.1 - 0.035 14.4 0.5 0.72 10.2 0.0 3.1 4 0 0 4 4 4 0 PPR repeat DUF4919 PF16266.5 PIK44182.1 - 0.042 13.8 0.3 0.071 13.1 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) TPR_4 PF07721.14 PIK44182.1 - 0.044 14.4 0.4 2.3 9.1 0.1 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK44182.1 - 0.075 12.9 3.0 0.18 11.7 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat CysG_dimeriser PF10414.9 PIK44182.1 - 0.093 12.5 0.3 0.19 11.5 0.3 1.5 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region TPR_6 PF13174.6 PIK44182.1 - 0.13 13.0 6.9 1.9 9.3 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 PIK44182.1 - 0.15 12.0 3.7 0.31 11.1 0.5 2.4 1 1 1 2 2 2 0 Putative TPR-like repeat Com_YlbF PF06133.11 PIK44182.1 - 0.37 11.4 4.5 1.1 9.9 3.3 2.5 2 1 0 2 2 1 0 Control of competence regulator ComK, YlbF/YmcA TPR_9 PF13371.6 PIK44182.1 - 1.2 9.3 3.7 27 5.0 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat Glyco_hydro_31 PF01055.26 PIK44183.1 - 4.4e-13 49.2 0.0 9.1e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 zf-met PF12874.7 PIK44185.1 - 6.3e-16 58.2 14.0 6.6e-07 29.5 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK44185.1 - 1.4e-11 44.3 13.5 0.00018 21.7 0.1 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding DUF2428 PF10350.9 PIK44185.1 - 0.025 13.8 0.1 0.041 13.1 0.1 1.4 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) zf-C2H2_2 PF12756.7 PIK44185.1 - 0.61 10.5 15.4 1.1 9.6 0.2 4.2 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 PIK44185.1 - 1.5 9.9 14.8 11 7.1 0.1 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger DZF PF07528.14 PIK44186.1 - 4.3e-54 183.8 0.0 5.2e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 DZF domain Tropomyosin PF00261.20 PIK44187.1 - 1.5e-51 175.0 69.2 6.5e-47 159.9 49.5 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 PIK44187.1 - 2.8e-20 72.9 71.2 1.7e-19 70.4 39.4 2.9 1 1 2 3 3 3 2 Tropomyosin like ATG16 PF08614.11 PIK44187.1 - 3.7e-06 27.3 62.9 9.9e-05 22.7 31.0 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) DUF724 PF05266.14 PIK44187.1 - 4.2e-05 23.5 55.1 0.041 13.7 16.0 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF724) CALCOCO1 PF07888.11 PIK44187.1 - 7.4e-05 21.8 42.3 7.4e-05 21.8 42.3 2.0 1 1 1 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like CLZ PF16526.5 PIK44187.1 - 0.0019 18.5 7.8 0.0019 18.5 7.8 5.9 1 1 4 5 5 5 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 PIK44187.1 - 0.0023 18.0 53.8 0.12 12.4 16.6 3.6 1 1 2 3 3 3 2 Afadin- and alpha -actinin-Binding DUF3584 PF12128.8 PIK44187.1 - 0.017 12.7 49.6 0.03 11.9 49.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) XhlA PF10779.9 PIK44187.1 - 0.024 14.8 3.7 0.024 14.8 3.7 6.3 3 2 3 6 6 6 0 Haemolysin XhlA Golgin_A5 PF09787.9 PIK44187.1 - 0.026 14.0 59.6 0.16 11.4 17.2 2.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 ERM PF00769.19 PIK44187.1 - 0.028 14.3 70.4 0.79 9.5 25.9 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family DUF4795 PF16043.5 PIK44187.1 - 0.033 13.8 53.3 0.067 12.8 28.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) UPF0242 PF06785.11 PIK44187.1 - 0.048 13.8 59.6 0.24 11.5 20.2 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 PIK44187.1 - 0.097 12.7 36.9 0.36 10.9 4.9 4.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CHASE3 PF05227.13 PIK44187.1 - 0.12 12.3 32.2 0.38 10.7 3.7 3.9 2 1 2 4 4 4 0 CHASE3 domain DASH_Hsk3 PF08227.11 PIK44187.1 - 0.16 12.3 15.5 0.26 11.7 0.1 4.6 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like PspA_IM30 PF04012.12 PIK44187.1 - 0.2 11.2 52.1 0.15 11.6 24.1 3.3 1 1 2 3 3 3 0 PspA/IM30 family Prominin PF05478.11 PIK44187.1 - 0.22 9.4 30.7 0.39 8.6 25.5 2.1 1 1 1 2 2 2 0 Prominin FlaC_arch PF05377.11 PIK44187.1 - 0.26 11.7 44.4 0.15 12.5 1.5 6.9 3 2 4 7 7 7 0 Flagella accessory protein C (FlaC) DUF1978 PF09321.10 PIK44187.1 - 0.29 10.4 53.4 4.4 6.5 35.8 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1978) BicD PF09730.9 PIK44187.1 - 0.36 9.2 49.3 0.42 9.0 16.9 2.9 1 1 2 3 3 3 0 Microtubule-associated protein Bicaudal-D Lebercilin PF15619.6 PIK44187.1 - 0.39 10.3 61.7 3.5 7.2 27.9 3.3 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Laminin_II PF06009.12 PIK44187.1 - 0.41 10.6 38.5 1.1 9.2 14.5 3.6 1 1 2 3 3 3 0 Laminin Domain II DUF4201 PF13870.6 PIK44187.1 - 0.58 9.9 50.6 6.2 6.5 25.4 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) Cep57_CLD PF14073.6 PIK44187.1 - 0.59 10.1 59.6 0.013 15.5 36.3 3.0 1 1 2 3 3 3 0 Centrosome localisation domain of Cep57 Fez1 PF06818.15 PIK44187.1 - 0.71 10.3 55.7 8.6 6.8 26.4 2.7 1 1 2 3 3 3 0 Fez1 Phage_GP20 PF06810.11 PIK44187.1 - 0.73 9.6 51.1 0.48 10.2 12.7 4.3 1 1 3 4 4 4 0 Phage minor structural protein GP20 MscS_porin PF12795.7 PIK44187.1 - 0.74 9.3 51.6 1.3 8.5 10.2 2.8 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF16 PF01519.16 PIK44187.1 - 0.83 10.2 43.7 0.76 10.3 10.1 3.7 1 1 2 3 3 3 0 Protein of unknown function DUF16 FH2 PF02181.23 PIK44187.1 - 1.2 8.1 37.9 0.68 9.0 7.5 3.4 1 1 2 3 3 3 0 Formin Homology 2 Domain DUF4686 PF15742.5 PIK44187.1 - 1.8 7.6 57.2 2.9 6.9 53.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) Spc7 PF08317.11 PIK44187.1 - 2.1 7.2 62.9 0.6 8.9 25.1 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein Fib_alpha PF08702.10 PIK44187.1 - 2.2 8.5 41.8 5.9 7.1 8.8 3.6 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF812 PF05667.11 PIK44187.1 - 2.3 7.0 61.9 4.1 6.2 22.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF812) Spectrin PF00435.21 PIK44187.1 - 2.4 8.7 43.5 2.5 8.7 8.4 4.3 1 1 3 4 4 4 0 Spectrin repeat EzrA PF06160.12 PIK44187.1 - 2.5 6.2 53.5 1.4 7.0 40.4 2.6 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Snapin_Pallidin PF14712.6 PIK44187.1 - 2.7 8.5 38.7 0.073 13.5 12.2 4.8 2 1 4 6 6 6 0 Snapin/Pallidin HOOK PF05622.12 PIK44187.1 - 2.8 6.0 58.2 1.3 7.1 22.8 2.7 1 1 1 2 2 2 0 HOOK protein MAD PF05557.13 PIK44187.1 - 3.2 6.0 57.2 5.4 5.3 57.2 1.4 1 0 0 1 1 1 0 Mitotic checkpoint protein AAA_13 PF13166.6 PIK44187.1 - 3.3 6.2 48.8 9.8 4.7 13.5 2.7 1 1 1 2 2 2 0 AAA domain GAS PF13851.6 PIK44187.1 - 4.6 6.5 59.3 5.5 6.3 15.8 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DivIVA PF05103.13 PIK44187.1 - 5.2 7.2 47.4 0.018 15.1 21.2 3.7 1 1 2 3 3 3 0 DivIVA protein Exonuc_VII_L PF02601.15 PIK44187.1 - 5.6 6.4 41.5 1.2 8.7 13.9 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit CC2-LZ PF16516.5 PIK44187.1 - 6.6 7.2 51.6 0.69 10.3 5.1 4.9 1 1 4 5 5 5 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Uds1 PF15456.6 PIK44187.1 - 6.8 6.9 49.9 18 5.5 9.4 4.5 1 1 2 3 3 2 0 Up-regulated During Septation Filament PF00038.21 PIK44187.1 - 6.8 6.2 54.3 3.8e+02 0.4 45.9 3.0 1 1 1 2 2 2 0 Intermediate filament protein CtIP_N PF10482.9 PIK44187.1 - 7.2 6.7 42.6 2.1 8.4 17.6 3.7 1 1 2 3 3 2 0 Tumour-suppressor protein CtIP N-terminal domain DUF745 PF05335.13 PIK44187.1 - 7.7 6.2 42.2 2.1 8.0 12.7 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF4200 PF13863.6 PIK44187.1 - 9.2 6.7 65.8 1.3 9.4 12.2 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.12 PIK44187.1 - 9.5 6.3 23.5 15 5.6 1.8 4.1 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CAF1A PF12253.8 PIK44188.1 - 1.3e-24 86.2 7.2 1.3e-24 86.2 7.2 5.2 4 2 1 5 5 5 1 Chromatin assembly factor 1 subunit A CAF1-p150_C2 PF15539.6 PIK44188.1 - 1.8e-17 63.8 19.3 4.3e-11 42.8 0.4 5.3 3 1 1 4 4 4 3 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF-1_p150 PF11600.8 PIK44188.1 - 1.9e-07 30.9 35.2 1.9e-07 30.9 35.2 1.9 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Tecti-min-caps PF09300.10 PIK44188.1 - 0.033 14.2 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Tectiviridae, minor capsid Glyco_hydro_30 PF02055.16 PIK44189.1 - 3.3e-140 467.0 0.2 4.5e-140 466.6 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 PIK44189.1 - 1.5e-12 47.5 0.0 2.5e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 PIK44189.1 - 8.4e-07 28.5 0.0 1.6e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 GTP_EFTU_D2 PF03144.25 PIK44190.1 - 1.3e-11 44.8 0.0 4.8e-11 42.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.24 PIK44190.1 - 4e-11 42.8 0.0 1.2e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 PIK44190.1 - 2.8e-06 27.3 0.0 7.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 PIK44190.1 - 0.0071 16.1 0.4 0.9 9.3 0.0 3.4 4 0 0 4 4 4 1 Elongation factor G, domain IV JmjC PF02373.22 PIK44190.1 - 0.19 12.2 0.0 0.86 10.1 0.0 2.1 2 0 0 2 2 2 0 JmjC domain, hydroxylase GTP_EFTU PF00009.27 PIK44191.1 - 7.6e-35 120.2 0.0 9.1e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK44191.1 - 0.011 15.7 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK44191.1 - 0.047 13.6 0.3 0.15 12.0 0.1 1.8 1 1 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 PIK44191.1 - 0.083 12.3 0.1 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK44191.1 - 0.1 11.7 0.1 0.2 10.8 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit Ras PF00071.22 PIK44191.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Ras family MFS_1 PF07690.16 PIK44192.1 - 2.6e-37 128.6 53.2 2.8e-24 85.7 21.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK44192.1 - 1.7e-08 33.8 32.7 0.00012 21.0 3.3 4.2 3 1 1 4 4 4 4 MFS_1 like family Phage_holin_2_4 PF16082.5 PIK44192.1 - 1.6 8.6 3.1 1 9.2 0.2 2.1 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like GCOM2 PF15328.6 PIK44193.1 - 1.3e-15 58.3 3.9 2.1e-15 57.7 3.6 1.4 1 1 0 1 1 1 1 Putative GRINL1B complex locus protein 2 NICE-3 PF07406.11 PIK44194.1 - 1.4e-45 155.5 0.8 1.9e-45 155.1 0.8 1.1 1 0 0 1 1 1 1 NICE-3 protein SCAN PF02023.17 PIK44195.1 - 2.5e-10 40.0 0.0 4e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 SCAN domain Integrase_H2C2 PF17921.1 PIK44196.1 - 3.3e-19 68.7 1.3 7.5e-19 67.6 1.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK44196.1 - 6.1e-19 68.4 0.0 1.8e-18 66.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK44196.1 - 0.0005 20.2 0.6 0.0017 18.6 0.6 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK44196.1 - 0.0044 16.8 0.2 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain rve PF00665.26 PIK44197.1 - 1.7e-21 76.6 0.0 3.3e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44197.1 - 5.9e-19 67.9 2.1 1.5e-18 66.6 2.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44197.1 - 0.0011 18.8 0.1 0.0027 17.4 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK44197.1 - 0.004 17.3 1.6 0.014 15.6 1.6 2.0 1 0 0 1 1 1 1 H2C2 zinc finger SOAR PF16533.5 PIK44197.1 - 0.063 13.3 0.1 18 5.3 0.0 2.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region Fibrinogen_C PF00147.18 PIK44198.1 - 2.4e-29 102.7 0.1 4.6e-26 92.0 0.2 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Calcyon PF06387.11 PIK44198.1 - 0.033 14.2 0.1 0.055 13.4 0.1 1.3 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) CRR7 PF12095.8 PIK44199.1 - 0.83 10.1 5.4 0.87 10.1 0.3 3.0 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Peptidase_C48 PF02902.19 PIK44200.1 - 2.7e-05 24.1 0.1 6.1e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PHD PF00628.29 PIK44200.1 - 3.2e-05 23.7 6.0 6.7e-05 22.7 6.0 1.6 1 0 0 1 1 1 1 PHD-finger SprT-like PF10263.9 PIK44200.1 - 0.00014 21.6 0.1 0.00026 20.8 0.1 1.5 1 0 0 1 1 1 1 SprT-like family C1_1 PF00130.22 PIK44200.1 - 0.14 12.1 6.0 0.091 12.7 1.2 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC24_OB3 PF17244.2 PIK44200.1 - 0.17 11.6 2.9 0.91 9.2 2.9 2.0 1 1 0 1 1 1 0 Cell division control protein 24, OB domain 3 Vps39_2 PF10367.9 PIK44200.1 - 0.29 11.6 1.8 0.79 10.2 1.8 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Ribosomal_L44 PF00935.19 PIK44201.1 - 0.00044 20.7 0.4 0.0011 19.5 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L44 zf-ACC PF17848.1 PIK44201.1 - 0.019 15.0 0.3 0.056 13.5 0.3 1.9 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2 PF00096.26 PIK44201.1 - 0.046 14.2 1.0 0.046 14.2 1.0 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK44201.1 - 0.083 12.7 0.5 0.083 12.7 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF951 PF06107.11 PIK44201.1 - 0.83 9.6 5.1 3.9 7.5 0.6 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) SDA1 PF05285.12 PIK44202.1 - 0.06 12.8 10.9 0.081 12.3 10.9 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 PIK44202.1 - 0.39 9.0 10.0 0.55 8.5 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 PIK44202.1 - 4.8 5.3 16.6 7.2 4.7 16.6 1.2 1 0 0 1 1 1 0 Nop14-like family zf-CCHC PF00098.23 PIK44203.1 - 1.4e-07 31.3 15.8 0.00043 20.2 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK44203.1 - 0.0002 21.1 7.7 0.064 13.1 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK44203.1 - 0.01 15.8 15.9 0.16 11.9 1.3 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK44203.1 - 0.011 15.5 11.1 3.2 7.6 0.4 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK44203.1 - 0.014 15.2 0.2 0.014 15.2 0.2 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK44203.1 - 0.014 15.1 0.8 0.014 15.1 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger THAP PF05485.12 PIK44204.1 - 3.2e-16 60.0 2.4 1e-15 58.4 0.1 2.9 3 0 0 3 3 3 1 THAP domain Ogr_Delta PF04606.12 PIK44204.1 - 0.53 10.3 2.8 23 5.1 0.3 2.9 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Phage_integrase PF00589.22 PIK44206.1 - 0.014 15.1 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Phage integrase family RVT_1 PF00078.27 PIK44207.1 - 5.2e-32 111.1 0.0 6.6e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ADAM_CR_2 PF17771.1 PIK44209.1 - 2.5e-14 53.5 21.2 5.4e-10 39.6 6.4 3.3 3 1 0 3 3 3 2 ADAM cysteine-rich domain Reprolysin PF01421.19 PIK44209.1 - 0.0059 16.5 1.0 0.031 14.2 0.6 2.1 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Cupin_8 PF13621.6 PIK44210.1 - 1.3e-32 113.5 0.1 1.4e-30 106.9 0.1 2.3 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK44210.1 - 1.1e-08 34.9 0.2 2.4e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.11 PIK44210.1 - 0.0075 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Zn_ribbon_2 PF12674.7 PIK44210.1 - 0.018 15.7 0.1 0.065 13.9 0.1 1.9 1 0 0 1 1 1 0 Putative zinc ribbon domain JmjC PF02373.22 PIK44210.1 - 0.025 15.0 0.0 0.12 12.8 0.0 2.3 1 1 0 1 1 1 0 JmjC domain, hydroxylase ParBc PF02195.18 PIK44211.1 - 7.3e-08 32.6 0.0 7.7e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain eIF3g PF12353.8 PIK44212.1 - 2e-37 128.4 1.1 3.8e-37 127.5 1.1 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 PIK44212.1 - 1.3e-19 69.8 0.0 2.3e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK44212.1 - 0.033 14.0 0.0 0.099 12.5 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 PIK44212.1 - 0.7 10.1 7.1 7.4 6.8 0.4 3.2 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter LRR_8 PF13855.6 PIK44214.1 - 1.5e-51 172.0 50.1 1.2e-12 47.4 0.8 8.2 2 2 5 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 PIK44214.1 - 6.6e-26 90.8 34.6 8.4e-11 41.9 3.2 4.6 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44214.1 - 6.8e-22 77.2 51.1 0.0024 18.3 0.3 9.6 4 1 4 10 10 10 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44214.1 - 4e-08 33.0 18.7 0.019 14.4 8.5 4.4 1 1 3 4 4 4 3 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK44214.1 - 0.00015 21.4 6.4 0.00015 21.4 6.4 4.6 3 1 2 5 5 5 3 Putative ephrin-receptor like LRR_1 PF00560.33 PIK44214.1 - 0.022 15.2 38.5 9.9 7.2 0.0 12.1 12 2 2 14 14 14 0 Leucine Rich Repeat T6SS_VipA PF05591.12 PIK44214.1 - 0.029 14.2 1.2 0.18 11.6 1.3 2.1 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 NCD3G PF07562.14 PIK44214.1 - 0.13 12.2 21.1 0.43 10.6 0.4 3.8 3 0 0 3 3 3 0 Nine Cysteines Domain of family 3 GPCR LRR_6 PF13516.6 PIK44214.1 - 2 8.7 31.5 2.8 8.2 0.1 8.5 10 0 0 10 10 10 0 Leucine Rich repeat PMP1_2 PF08114.11 PIK44215.1 - 0.0071 16.1 0.7 0.03 14.1 0.7 2.1 1 0 0 1 1 1 1 ATPase proteolipid family Cytochrom_C_asm PF01578.20 PIK44215.1 - 0.075 12.8 11.4 0.8 9.4 6.5 3.1 2 2 0 2 2 2 0 Cytochrome C assembly protein RVT_1 PF00078.27 PIK44216.1 - 1.6e-22 80.1 0.0 1.7e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipase PF00151.19 PIK44216.1 - 0.078 12.3 0.1 0.095 12.0 0.1 1.1 1 0 0 1 1 1 0 Lipase Exo_endo_phos_2 PF14529.6 PIK44217.1 - 0.0051 16.6 1.3 0.028 14.2 0.0 2.6 2 1 1 3 3 3 1 Endonuclease-reverse transcriptase Apolipoprotein PF01442.18 PIK44217.1 - 0.013 15.4 0.2 0.04 13.8 0.7 1.5 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF5582 PF17819.1 PIK44217.1 - 0.075 13.5 0.3 0.12 12.8 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5582) DUF883 PF05957.13 PIK44217.1 - 0.12 13.0 1.2 0.27 11.9 1.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) BEN PF10523.9 PIK44217.1 - 0.13 12.5 0.2 0.33 11.2 0.2 1.7 1 0 0 1 1 1 0 BEN domain Exo_endo_phos PF03372.23 PIK44217.1 - 0.15 11.6 0.0 0.18 11.3 0.0 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family zf-met PF12874.7 PIK44219.1 - 0.021 15.2 0.9 0.059 13.8 0.9 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK44219.1 - 0.028 14.9 0.6 0.028 14.9 0.6 3.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44219.1 - 0.036 14.9 0.5 0.036 14.9 0.5 3.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK44219.1 - 0.48 10.2 5.2 0.27 11.0 1.2 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type ER PF01133.17 PIK44220.1 - 0.016 15.2 0.4 0.038 14.0 0.2 1.8 2 0 0 2 2 2 0 Enhancer of rudimentary CARD_2 PF16739.5 PIK44220.1 - 0.17 11.9 0.7 0.23 11.4 0.1 1.6 2 0 0 2 2 2 0 Caspase recruitment domain Sulfotransfer_1 PF00685.27 PIK44221.1 - 2.1e-08 34.0 0.2 3.9e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK44221.1 - 7.9e-07 29.7 0.0 4.1e-05 24.1 0.0 2.6 1 1 0 1 1 1 1 Sulfotransferase family BACK PF07707.15 PIK44221.1 - 0.078 13.1 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch Sulfotransfer_2 PF03567.14 PIK44221.1 - 0.1 12.5 1.4 0.44 10.4 1.5 1.8 1 1 0 1 1 1 0 Sulfotransferase family MBOAT PF03062.19 PIK44222.1 - 4.1e-08 33.0 11.8 1.2e-05 24.9 0.7 2.4 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family AP3D1 PF06375.11 PIK44222.1 - 0.22 11.7 4.8 0.1 12.9 2.4 1.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 TTC5_OB PF16669.5 PIK44223.1 - 1.3e-38 131.2 0.1 1.9e-38 130.7 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_11 PF13414.6 PIK44224.1 - 6.6e-10 38.5 0.2 1.9e-06 27.5 0.0 4.7 4 1 1 5 5 5 1 TPR repeat TPR_8 PF13181.6 PIK44224.1 - 1.6e-08 34.1 1.9 2.7e-05 24.0 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK44224.1 - 1.7e-07 30.7 6.6 0.00075 19.2 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK44224.1 - 2.7e-07 30.2 7.1 0.00018 21.4 0.1 4.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK44224.1 - 2.2e-05 24.5 0.5 0.015 15.6 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK44224.1 - 5.2e-05 23.8 0.0 0.00017 22.2 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK44224.1 - 9.4e-05 22.6 0.1 0.015 15.6 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK44224.1 - 0.00035 21.0 0.0 0.0012 19.3 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK44224.1 - 0.00044 20.8 0.0 0.03 15.1 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK44224.1 - 0.0025 16.9 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) FAT PF02259.23 PIK44224.1 - 0.0041 16.4 0.1 0.0056 15.9 0.1 1.2 1 0 0 1 1 1 1 FAT domain TPR_7 PF13176.6 PIK44224.1 - 0.088 12.9 0.0 0.56 10.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1186 PF06685.11 PIK44224.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) FeS_assembly_P PF01883.19 PIK44225.1 - 1.3e-14 54.1 0.0 2.8e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Robl_LC7 PF03259.17 PIK44226.1 - 5.6e-22 77.3 0.0 7.3e-22 76.9 0.0 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain UPF0176_N PF17773.1 PIK44226.1 - 0.06 13.7 0.0 0.082 13.3 0.0 1.2 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain Robl_LC7 PF03259.17 PIK44227.1 - 9.8e-26 89.4 0.0 1.1e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 PIK44227.1 - 0.0015 18.4 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 UPF0176_N PF17773.1 PIK44227.1 - 0.081 13.3 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain vATP-synt_AC39 PF01992.16 PIK44228.1 - 5.3e-94 315.5 0.1 3.5e-89 299.6 0.2 2.0 1 1 1 2 2 2 2 ATP synthase (C/AC39) subunit Nab2p_Zf1 PF18260.1 PIK44228.1 - 0.063 13.2 0.7 0.3 11.0 0.0 2.1 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 AdoHcyase PF05221.17 PIK44229.1 - 2.3e-34 118.9 0.0 2.6e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 PIK44230.1 - 5.7e-39 133.8 0.3 7.7e-39 133.4 0.3 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 PIK44230.1 - 1.4e-36 126.2 0.0 1.6e-36 126.0 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase SRCR PF00530.18 PIK44232.1 - 2.4e-30 105.0 2.8 4.8e-18 65.5 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44232.1 - 1.5e-05 25.5 14.1 4.8e-05 23.8 2.1 3.1 2 2 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44232.1 - 0.028 14.9 0.8 0.64 10.6 0.1 2.4 2 0 0 2 2 2 0 Hepsin, SRCR domain NicO PF03824.16 PIK44233.1 - 0.0011 18.4 0.1 0.0014 18.0 0.1 1.1 1 0 0 1 1 1 1 High-affinity nickel-transport protein O-antigen_lig PF13425.6 PIK44233.1 - 0.11 11.3 0.0 0.13 11.1 0.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2207 PF09972.9 PIK44233.1 - 0.14 10.9 0.2 0.19 10.5 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1129 PF06570.11 PIK44233.1 - 0.19 11.2 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) cNMP_binding PF00027.29 PIK44234.1 - 4.5e-08 33.0 0.0 9.3e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain LRR_11 PF18831.1 PIK44235.1 - 0.12 12.0 0.1 0.35 10.5 0.1 1.8 1 0 0 1 1 1 0 Leucine-rich repeat ECH_1 PF00378.20 PIK44236.1 - 7.6e-37 127.0 0.0 9e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK44236.1 - 4.8e-15 55.9 0.0 6.1e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase MIT_C PF16565.5 PIK44236.1 - 0.014 15.3 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT Chromo PF00385.24 PIK44237.1 - 1.9e-16 59.7 1.0 3.1e-16 59.0 1.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 PIK44237.1 - 7.7e-06 26.0 0.5 1.4e-05 25.2 0.5 1.4 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 GCIP PF13324.6 PIK44238.1 - 4.7e-60 203.4 0.2 7.5e-60 202.7 0.2 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF2096 PF09869.9 PIK44238.1 - 0.02 15.0 0.1 0.088 12.9 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) MYEOV2 PF15004.6 PIK44239.1 - 8.1e-32 109.5 6.9 8.9e-32 109.3 6.9 1.0 1 0 0 1 1 1 1 Myeloma-overexpressed-like SLIDE PF09111.10 PIK44240.1 - 1.1e-38 131.8 0.2 1.4e-38 131.4 0.2 1.2 1 0 0 1 1 1 1 SLIDE Myb_DNA-binding PF00249.31 PIK44240.1 - 0.00054 20.1 0.1 0.00094 19.3 0.1 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain SNF2_N PF00176.23 PIK44241.1 - 8e-61 205.7 0.1 1.8e-59 201.2 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain HAND PF09110.11 PIK44241.1 - 1.2e-29 103.3 0.1 1.2e-29 103.3 0.1 3.1 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 PIK44241.1 - 6.5e-19 68.3 0.0 2.1e-18 66.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK44241.1 - 2e-08 34.4 0.0 5.6e-07 29.7 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DBINO PF13892.6 PIK44241.1 - 2.2e-05 24.8 0.4 2.2e-05 24.8 0.4 2.8 2 0 0 2 2 2 1 DNA-binding domain DEAD PF00270.29 PIK44241.1 - 5.1e-05 23.1 0.0 0.00027 20.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 PIK44241.1 - 0.0037 17.0 0.0 0.012 15.3 0.0 1.9 1 1 0 1 1 1 1 SWI2/SNF2 ATPase HDA2-3 PF11496.8 PIK44241.1 - 0.0098 15.1 0.0 0.03 13.5 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 PIK44241.1 - 0.01 15.1 0.0 0.023 13.9 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Myb_DNA-binding PF00249.31 PIK44241.1 - 0.069 13.4 0.0 0.069 13.4 0.0 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain DHC_N2 PF08393.13 PIK44243.1 - 5.2e-25 88.4 2.2 6.6e-25 88.1 2.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DHC_N2 PF08393.13 PIK44244.1 - 1.2e-27 97.0 0.1 1.5e-27 96.8 0.1 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DUF600 PF04634.12 PIK44244.1 - 0.046 13.8 0.1 0.063 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF600 SesA PF17107.5 PIK44244.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.5 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases AAA_6 PF12774.7 PIK44245.1 - 9.2e-20 70.9 0.0 6.9e-17 61.4 0.0 3.0 3 0 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 PIK44245.1 - 0.087 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Myc-LZ PF02344.15 PIK44245.1 - 0.092 12.9 3.6 0.95 9.6 0.7 2.6 2 0 0 2 2 2 0 Myc leucine zipper domain Transformer PF06495.11 PIK44245.1 - 0.15 12.2 2.6 0.29 11.2 2.6 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein AAA_8 PF12780.7 PIK44246.1 - 1.7e-41 142.3 0.0 2.7e-40 138.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.7 PIK44246.1 - 5.7e-26 91.4 1.2 9.1e-26 90.7 1.2 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 PIK44246.1 - 9e-20 70.9 0.0 6.6e-15 55.1 0.0 2.8 3 0 0 3 3 2 2 P-loop containing dynein motor region AAA_9 PF12781.7 PIK44246.1 - 2.2e-18 66.2 0.1 1.9e-16 59.9 0.1 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_heavy PF03028.15 PIK44246.1 - 3.7e-16 59.3 0.1 2.4e-15 56.7 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 PIK44246.1 - 2.2e-11 43.9 0.0 7e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 PIK44246.1 - 7e-11 42.3 0.0 2.9e-10 40.3 0.0 2.2 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 PIK44246.1 - 8.1e-07 29.4 0.1 0.046 14.0 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 PIK44246.1 - 4.1e-06 26.8 0.1 1.1 9.2 0.0 4.3 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) Dynein_C PF18199.1 PIK44246.1 - 5.9e-06 25.7 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_16 PF13191.6 PIK44246.1 - 7.5e-06 26.4 0.0 0.18 12.1 0.0 3.7 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 PIK44246.1 - 2.4e-05 24.5 0.0 0.12 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 PIK44246.1 - 8.8e-05 22.9 2.3 2.4 8.6 0.0 4.1 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK44246.1 - 0.00056 20.5 0.0 0.23 12.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK44246.1 - 0.0021 18.0 0.1 3.2 7.6 0.0 3.2 3 0 0 3 3 2 1 NACHT domain AAA_lid_1 PF17857.1 PIK44246.1 - 0.0038 17.4 0.1 0.074 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain RsgA_GTPase PF03193.16 PIK44246.1 - 0.0052 16.7 0.0 0.25 11.2 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 PIK44246.1 - 0.0075 16.6 0.0 4.9 7.6 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_19 PF13245.6 PIK44246.1 - 0.0097 16.3 0.0 1.4 9.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 PIK44246.1 - 0.0098 15.3 3.3 0.46 9.8 0.0 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 PIK44246.1 - 0.012 15.3 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_6 PF12774.7 PIK44246.1 - 0.054 12.4 0.1 0.14 11.1 0.1 1.7 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 PIK44246.1 - 0.058 13.4 0.0 7.2 6.6 0.0 2.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 PIK44246.1 - 0.065 13.7 0.7 23 5.5 0.0 3.7 4 0 0 4 4 3 0 ABC transporter FtsK_SpoIIIE PF01580.18 PIK44246.1 - 0.083 12.2 0.0 8.2 5.7 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 PIK44246.1 - 0.093 12.4 0.0 7.4 6.3 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 PIK44246.1 - 0.2 11.6 0.1 21 5.0 0.0 3.1 3 0 0 3 3 3 0 NTPase ALMT PF11744.8 PIK44246.1 - 0.23 10.2 2.0 0.51 9.1 2.0 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Fez1 PF06818.15 PIK44246.1 - 6.5 7.2 13.3 9 6.7 1.0 3.6 3 0 0 3 3 3 0 Fez1 Dynein_C PF18199.1 PIK44247.1 - 1.1e-20 74.1 0.1 1.2e-20 74.0 0.1 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Exo_endo_phos_2 PF14529.6 PIK44248.1 - 2.2e-08 34.0 0.2 3.1e-08 33.5 0.2 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK44248.1 - 0.016 14.7 0.0 0.021 14.4 0.0 1.3 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Raffinose_syn PF05691.12 PIK44249.1 - 0.37 8.5 1.6 0.49 8.1 1.6 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 RVT_1 PF00078.27 PIK44251.1 - 4.2e-10 39.5 0.0 6.7e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44252.1 - 2e-32 111.2 0.0 3.5e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44252.1 - 2.6e-25 88.7 0.0 4.6e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Spermine_synth PF01564.17 PIK44253.1 - 1.2e-19 70.5 0.0 1.7e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synth PF01564.17 PIK44254.1 - 1.8e-07 30.8 0.0 2.2e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 PIK44254.1 - 0.0006 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain RVT_1 PF00078.27 PIK44256.1 - 2.6e-22 79.5 0.0 4.1e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SET PF00856.28 PIK44257.1 - 5.7e-08 33.3 0.0 3.1e-07 30.9 0.0 1.9 1 1 0 1 1 1 1 SET domain Mito_carr PF00153.27 PIK44258.1 - 4.6e-14 52.1 0.1 1e-05 25.4 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Pkinase PF00069.25 PIK44259.1 - 0.0013 18.2 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44259.1 - 0.0022 17.3 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3261 PF11659.8 PIK44259.1 - 0.067 13.1 4.2 4.5 7.1 0.0 5.3 1 1 4 6 6 6 0 Protein of unknown function (DUF3261) UPF1_Zn_bind PF09416.10 PIK44259.1 - 0.12 12.3 3.8 2.8 7.9 1.0 2.6 1 1 1 2 2 2 0 RNA helicase (UPF2 interacting domain) 3HCDH_N PF02737.18 PIK44260.1 - 5e-50 169.9 0.0 8.4e-50 169.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 PIK44260.1 - 7.4e-15 55.3 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 PIK44260.1 - 1.6e-06 28.4 0.0 3.9e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 PIK44260.1 - 5.9e-05 22.5 0.0 9.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 PIK44260.1 - 0.00041 20.0 0.1 0.0007 19.2 0.1 1.6 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 PIK44260.1 - 0.0025 17.8 0.0 0.0063 16.5 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_2 PF07992.14 PIK44260.1 - 0.044 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 PIK44260.1 - 0.12 13.0 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 PIK44260.1 - 0.18 11.4 0.1 0.33 10.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 7tm_1 PF00001.21 PIK44261.1 - 3.6e-27 95.4 12.0 4.4e-27 95.1 12.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK44261.1 - 0.0019 17.9 19.5 0.0032 17.1 19.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK44261.1 - 0.0039 16.6 11.9 0.0059 16.0 11.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PID_2 PF14719.6 PIK44261.1 - 0.064 13.1 0.1 0.093 12.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF5381 PF17353.2 PIK44261.1 - 1.6 8.5 5.2 0.18 11.6 0.9 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5381) ANF_receptor PF01094.28 PIK44262.1 - 7.5e-47 160.1 0.0 3.5e-39 134.9 0.1 2.0 1 1 1 2 2 2 2 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK44262.1 - 0.0014 18.4 0.0 0.0019 17.9 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 PIK44263.1 - 1.2e-28 100.3 0.0 1.6e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 PIK44263.1 - 8.1e-20 71.6 9.5 6.6e-16 58.8 7.5 2.2 1 1 1 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK44263.1 - 9.8e-09 35.1 10.0 2.5e-08 33.8 10.0 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 PIK44263.1 - 0.00025 20.8 0.1 0.00038 20.2 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Cation_efflux PF01545.21 PIK44263.1 - 0.027 14.2 1.1 0.046 13.4 1.1 1.3 1 0 0 1 1 1 0 Cation efflux family Pneumo_NS1 PF03438.13 PIK44263.1 - 0.1 12.8 0.3 0.24 11.5 0.3 1.7 1 0 0 1 1 1 0 Pneumovirus NS1 protein DUF485 PF04341.12 PIK44263.1 - 0.18 11.8 1.8 4 7.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF485 COX2_TM PF02790.15 PIK44263.1 - 4 7.7 5.6 2 8.6 2.3 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DNA_pol_B PF00136.21 PIK44264.1 - 7.8e-99 331.4 0.1 1.1e-98 331.0 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 PIK44264.1 - 2.3e-17 63.1 0.0 5.5e-17 61.9 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 PIK44264.1 - 3.8e-10 40.1 7.8 8.5e-10 39.0 7.8 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta BIR PF00653.21 PIK44269.1 - 3.6e-57 190.9 5.1 1.8e-19 70.2 0.3 3.5 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 PIK44270.1 - 3.9e-15 55.4 7.3 5.9e-15 54.9 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DED PF01335.21 PIK44270.1 - 3.4e-11 43.3 0.1 0.00023 21.4 0.0 3.2 2 1 0 3 3 3 2 Death effector domain Prok-RING_4 PF14447.6 PIK44270.1 - 1.1e-07 31.6 7.3 1.9e-07 30.8 7.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 PIK44270.1 - 0.00019 21.2 5.5 0.0035 17.2 6.2 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK44270.1 - 0.0018 18.6 9.8 0.0044 17.3 9.8 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK44270.1 - 0.0025 17.6 8.2 0.005 16.7 8.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PCM1_C PF15717.5 PIK44270.1 - 0.019 13.7 3.5 0.024 13.4 3.5 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus zf-RING_5 PF14634.6 PIK44270.1 - 0.035 14.1 8.3 0.067 13.2 8.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF1323 PF07037.11 PIK44270.1 - 0.43 11.0 2.7 0.77 10.1 0.8 2.0 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) zf-C3H2C3 PF17122.5 PIK44270.1 - 0.84 9.7 7.9 1.4 9.1 7.9 1.3 1 0 0 1 1 1 0 Zinc-finger BIR PF00653.21 PIK44271.1 - 3.1e-56 188.0 3.6 1.8e-18 66.9 0.3 3.6 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain Sfi1 PF08457.10 PIK44272.1 - 1.4e-07 30.5 95.6 2.7e-05 22.9 36.5 5.3 1 1 4 5 5 5 5 Sfi1 spindle body protein Solute_trans_a PF03619.16 PIK44273.1 - 2.5e-36 125.6 13.2 3.4e-36 125.1 13.2 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Proton_antipo_N PF00662.20 PIK44273.1 - 5.2 7.2 7.5 2.1 8.5 1.6 2.7 2 1 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DUF1647 PF07801.11 PIK44274.1 - 1.9e-07 30.9 0.0 3.8e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) LPMO_10 PF03067.15 PIK44275.1 - 0.00035 21.3 0.1 0.00065 20.4 0.1 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading MBG_2 PF18676.1 PIK44275.1 - 0.33 11.6 2.9 4.1 8.1 0.2 3.0 3 0 0 3 3 3 0 MBG domain (YGX type) ANF_receptor PF01094.28 PIK44276.1 - 6.6e-46 157.0 0.0 7.1e-23 81.3 0.0 2.2 1 1 1 2 2 2 2 Receptor family ligand binding region 7tm_3 PF00003.22 PIK44276.1 - 2.6e-15 56.8 16.7 9.2e-15 55.0 16.7 1.9 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK44276.1 - 2.6e-10 40.1 12.9 5.9e-10 39.0 12.9 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 PIK44276.1 - 0.021 14.5 0.2 6 6.4 0.0 2.2 1 1 1 2 2 2 0 Periplasmic binding protein OTU PF02338.19 PIK44277.1 - 1e-18 68.1 0.0 2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.16 PIK44277.1 - 1.5e-05 24.8 6.6 0.0012 18.7 0.7 6.7 7 1 0 7 7 7 2 A20-like zinc finger TGFb_propeptide PF00688.18 PIK44277.1 - 0.84 9.3 6.5 1.3 8.7 5.5 1.7 1 1 1 2 2 2 0 TGF-beta propeptide DUF4570 PF15134.6 PIK44277.1 - 1.3 9.1 4.7 8.3 6.5 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) WD40 PF00400.32 PIK44278.1 - 1.6e-06 28.7 0.4 0.054 14.4 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 PIK44279.1 - 0.026 15.4 0.1 13 6.8 0.0 2.9 3 0 0 3 3 3 0 WD domain, G-beta repeat PBP PF01161.20 PIK44280.1 - 3e-21 76.1 0.1 4e-21 75.7 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein 7tm_3 PF00003.22 PIK44281.1 - 2.3e-54 184.7 25.7 3.3e-54 184.1 25.7 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK44281.1 - 3.1e-12 46.3 11.9 3.1e-12 46.3 11.9 2.0 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR NACHT PF05729.12 PIK44282.1 - 3.8e-16 59.4 0.2 6.1e-16 58.8 0.2 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK44282.1 - 3e-07 30.8 0.0 5.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK44282.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.9 PIK44282.1 - 0.02 14.1 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK44282.1 - 0.02 15.3 0.0 0.047 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_11 PF13086.6 PIK44282.1 - 0.022 14.6 0.0 0.07 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 PIK44282.1 - 0.027 13.6 0.1 0.15 11.3 0.1 2.0 1 1 0 1 1 1 0 NB-ARC domain CDRN PF05174.12 PIK44282.1 - 0.072 12.8 0.0 0.83 9.4 0.0 2.6 3 0 0 3 3 3 0 Cysteine-rich D. radiodurans N terminus AAA_5 PF07728.14 PIK44282.1 - 0.093 12.7 0.4 0.32 11.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 PIK44282.1 - 0.12 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK44282.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain HYR PF02494.16 PIK44284.1 - 1.3e-05 25.4 0.3 3.6e-05 24.0 0.2 1.9 2 0 0 2 2 2 1 HYR domain Sigma_reg_N PF13800.6 PIK44284.1 - 0.19 12.1 1.0 0.45 10.8 1.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal SRCR PF00530.18 PIK44285.1 - 4.5e-26 91.3 0.1 5.9e-26 90.9 0.1 1.2 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44285.1 - 9.1e-05 22.9 0.0 0.00015 22.2 0.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF3304 PF11745.8 PIK44286.1 - 0.91 9.9 7.2 1.2 9.6 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3304) CwfJ_C_2 PF04676.14 PIK44287.1 - 3.2e-17 63.2 0.1 7.7e-17 62.0 0.1 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Inhibitor_I9 PF05922.16 PIK44289.1 - 9e-06 26.3 0.0 1.3e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 PIK44289.1 - 6.7e-05 22.3 1.8 0.00017 21.0 1.8 1.6 1 1 0 1 1 1 1 Subtilase family Peptidase_S8 PF00082.22 PIK44290.1 - 1.1e-20 74.1 8.7 1.3e-20 73.9 8.7 1.0 1 0 0 1 1 1 1 Subtilase family Pkinase_Tyr PF07714.17 PIK44291.1 - 2.8e-11 43.2 0.1 4.9e-11 42.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK44291.1 - 2.5e-06 28.0 4.8 0.023 15.3 0.2 5.2 4 0 0 4 4 4 1 Immunoglobulin domain Pkinase PF00069.25 PIK44291.1 - 3.3e-06 26.7 0.0 7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK44291.1 - 5.2e-06 26.4 12.0 1.6e-05 24.9 0.4 3.9 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK44291.1 - 9.8e-05 22.6 4.4 1.1 9.6 0.1 4.6 4 0 0 4 4 4 2 Immunoglobulin domain C1-set PF07654.15 PIK44291.1 - 0.0013 19.1 2.2 0.37 11.2 0.1 3.6 3 0 0 3 3 3 1 Immunoglobulin C1-set domain DUF2371 PF10177.9 PIK44291.1 - 0.25 11.5 0.0 0.25 11.5 0.0 3.7 3 2 2 5 5 5 0 Uncharacterised conserved protein (DUF2371) V-set PF07686.17 PIK44292.1 - 1.3e-08 35.0 1.2 0.00022 21.4 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin V-set domain NACHT PF05729.12 PIK44292.1 - 2.3e-07 30.9 0.0 4.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK44292.1 - 1.1e-06 29.2 11.0 0.0023 18.5 0.1 5.4 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK44292.1 - 0.0067 16.5 2.2 2.7 8.1 0.1 3.9 3 1 0 3 3 3 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK44292.1 - 0.081 13.0 1.7 6.9 6.8 0.1 2.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK44292.1 - 0.54 10.5 13.1 1.4 9.2 0.0 5.2 7 0 0 7 7 7 0 Immunoglobulin domain NACHT PF05729.12 PIK44293.1 - 4.7e-16 59.1 0.0 9.2e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK44293.1 - 0.00049 19.7 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK44293.1 - 0.00069 19.9 0.0 0.0036 17.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain DAP3 PF10236.9 PIK44293.1 - 0.016 14.4 0.2 0.61 9.2 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK44293.1 - 0.13 12.7 0.0 1 9.7 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain WD40 PF00400.32 PIK44295.1 - 2.6e-61 202.1 14.3 5.5e-10 39.7 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44295.1 - 7.9e-18 64.6 1.5 0.0058 16.9 0.0 7.0 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK44295.1 - 3.7e-09 35.8 8.6 0.0041 15.8 0.1 6.0 1 1 6 7 7 7 3 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK44295.1 - 7.5e-08 32.1 1.2 0.056 12.8 0.0 4.6 2 2 2 5 5 5 3 WD40-like domain CEP19 PF14933.6 PIK44295.1 - 0.00011 22.6 0.1 0.00019 21.7 0.1 1.4 1 0 0 1 1 1 1 CEP19-like protein Ge1_WD40 PF16529.5 PIK44295.1 - 0.00038 19.5 8.5 0.4 9.6 1.0 4.6 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 PIK44295.1 - 0.0029 17.6 0.3 0.5 10.4 0.0 3.6 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF1258 PF06869.12 PIK44295.1 - 0.011 15.3 0.1 0.032 13.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) CEP19 PF14933.6 PIK44296.1 - 7.9e-48 162.9 0.5 8.9e-48 162.7 0.5 1.0 1 0 0 1 1 1 1 CEP19-like protein Peptidase_M3 PF01432.20 PIK44297.1 - 2e-134 449.3 0.2 3e-134 448.7 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M3 HTH_OrfB_IS605 PF12323.8 PIK44297.1 - 0.0016 17.9 0.0 0.0034 16.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain CAP_GLY PF01302.25 PIK44299.1 - 1.8e-16 59.9 0.6 2.9e-16 59.3 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain RITA PF17066.5 PIK44299.1 - 0.0036 16.9 1.9 0.0042 16.7 0.4 1.8 1 1 1 2 2 2 1 RBPJ-interacting and tubulin associated protein SPC25 PF06703.11 PIK44300.1 - 3.5e-18 65.9 0.0 3.9e-18 65.8 0.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) SPC25 PF06703.11 PIK44301.1 - 6.1e-20 71.6 0.4 1.1e-19 70.8 0.4 1.4 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) UPF0257 PF06788.13 PIK44301.1 - 0.021 14.7 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) HEAT_2 PF13646.6 PIK44302.1 - 1.6e-12 47.6 5.9 1.3e-06 28.7 0.0 5.2 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 PIK44302.1 - 3.4e-12 45.5 2.1 0.057 13.7 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.7 PIK44302.1 - 1e-07 32.2 7.2 0.084 12.9 0.5 5.4 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 PIK44302.1 - 0.014 15.6 2.0 5.8 7.1 0.0 4.3 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 PIK44302.1 - 0.031 12.8 6.6 1.1 7.7 1.0 3.1 3 0 0 3 3 3 0 Adaptin N terminal region OHCU_decarbox PF09349.10 PIK44302.1 - 0.13 12.8 0.3 0.42 11.1 0.3 1.8 1 0 0 1 1 1 0 OHCU decarboxylase Sterol_MT_C PF08498.10 PIK44302.1 - 0.16 12.3 0.0 0.45 10.9 0.0 1.7 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal DUF4498 PF14926.6 PIK44303.1 - 3.2e-56 190.4 0.8 3.3e-56 190.4 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) TLD PF07534.16 PIK44304.1 - 8.9e-27 94.0 0.1 5.5e-26 91.4 0.0 2.1 2 0 0 2 2 2 1 TLD RabGAP-TBC PF00566.18 PIK44304.1 - 7.8e-21 74.7 1.4 1.2e-20 74.1 1.4 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4407 PF14362.6 PIK44305.1 - 0.13 11.6 0.9 0.15 11.4 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 5_nucleotid PF05761.14 PIK44306.1 - 1.6e-107 360.3 0.0 1.9e-107 360.0 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 PIK44306.1 - 0.082 13.0 0.0 0.35 10.9 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Arylesterase PF01731.20 PIK44307.1 - 2.8e-14 53.1 0.0 7.9e-14 51.6 0.0 1.8 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 PIK44307.1 - 1.1e-05 25.2 0.0 2.2e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 PIK44307.1 - 0.04 13.2 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.20 PIK44308.1 - 0.0003 20.9 0.0 0.00062 19.9 0.0 1.6 1 0 0 1 1 1 1 Arylesterase Afaf PF15339.6 PIK44309.1 - 0.055 13.2 9.0 0.12 12.1 9.0 1.5 1 0 0 1 1 1 0 Acrosome formation-associated factor LMBR1 PF04791.16 PIK44309.1 - 2.5 6.9 10.3 2.7 6.8 10.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SPT2 PF08243.11 PIK44310.1 - 4.4e-14 53.0 3.8 6.8e-14 52.3 3.8 1.3 1 0 0 1 1 1 1 SPT2 chromatin protein Sigma70_r3 PF04539.16 PIK44310.1 - 0.038 14.1 0.1 0.073 13.2 0.1 1.4 1 0 0 1 1 1 0 Sigma-70 region 3 FAM47 PF14642.6 PIK44312.1 - 5.4e-11 42.5 0.2 7.3e-11 42.1 0.2 1.2 1 0 0 1 1 1 1 FAM47 family CENP-F_leu_zip PF10473.9 PIK44313.1 - 2.4e-06 27.6 99.9 0.0061 16.6 11.4 5.7 1 1 4 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Takusan PF04822.13 PIK44313.1 - 2.8e-05 23.9 4.4 2.8e-05 23.9 4.4 6.1 4 2 2 6 6 5 2 Takusan ATG16 PF08614.11 PIK44313.1 - 0.00015 22.1 105.6 0.19 11.9 19.7 5.9 1 1 4 5 5 5 2 Autophagy protein 16 (ATG16) IFT57 PF10498.9 PIK44313.1 - 0.00037 19.6 15.6 0.00037 19.6 15.6 5.0 1 1 4 5 5 5 1 Intra-flagellar transport protein 57 DUF1664 PF07889.12 PIK44313.1 - 0.0032 17.5 49.5 0.25 11.4 3.3 6.5 4 1 2 6 6 6 3 Protein of unknown function (DUF1664) Fez1 PF06818.15 PIK44313.1 - 0.019 15.4 86.8 0.14 12.6 29.2 5.2 1 1 4 5 5 5 0 Fez1 GAS PF13851.6 PIK44313.1 - 0.035 13.5 92.2 0.013 14.8 11.2 6.2 1 1 6 7 7 7 0 Growth-arrest specific micro-tubule binding DUF4732 PF15876.5 PIK44313.1 - 0.044 13.9 1.3 0.33 11.0 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4732) Prp19 PF08606.11 PIK44313.1 - 0.049 13.6 0.5 0.049 13.6 0.5 5.9 6 3 2 8 8 8 0 Prp19/Pso4-like Fungal_TACC PF12709.7 PIK44313.1 - 0.066 13.7 0.3 0.066 13.7 0.3 10.0 4 3 9 13 13 13 0 Fungal Transforming acidic coiled-coil (TACC) proteins ADIP PF11559.8 PIK44313.1 - 0.07 13.2 95.1 0.72 9.9 4.7 7.4 1 1 6 7 7 7 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 PIK44313.1 - 0.2 11.7 92.9 0.14 12.3 9.0 6.2 1 1 4 5 5 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF4618 PF15397.6 PIK44313.1 - 0.31 10.4 71.7 0.011 15.1 20.5 4.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4618) Tropomyosin_1 PF12718.7 PIK44313.1 - 0.34 11.1 86.6 1.4 9.1 14.3 6.3 1 1 3 5 5 5 0 Tropomyosin like HMMR_N PF15905.5 PIK44313.1 - 0.7 9.3 89.9 0.36 10.3 19.5 5.5 1 1 3 5 5 5 0 Hyaluronan mediated motility receptor N-terminal FPP PF05911.11 PIK44313.1 - 0.97 7.5 86.6 0.073 11.3 19.5 4.0 1 1 3 4 4 4 0 Filament-like plant protein, long coiled-coil SCVP PF17619.2 PIK44313.1 - 1.2 10.0 4.5 0.95 10.4 0.3 3.1 3 0 0 3 3 2 0 Secreted clade V proteins Bacillus_HBL PF05791.11 PIK44313.1 - 1.7 8.5 39.5 0.33 10.8 5.7 5.5 3 2 1 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.9 PIK44313.1 - 2.1 7.3 84.3 0.12 11.4 18.8 4.5 1 1 2 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 PIK44313.1 - 2.8 8.0 97.3 0.45 10.6 16.9 7.0 1 1 7 8 8 8 0 TPR/MLP1/MLP2-like protein Filament PF00038.21 PIK44313.1 - 3.1 7.3 88.3 1.4 8.4 33.8 5.2 1 1 2 3 3 3 0 Intermediate filament protein APG6_N PF17675.1 PIK44313.1 - 6.4 7.3 105.8 0.41 11.2 13.6 7.0 1 1 5 6 6 5 0 Apg6 coiled-coil region DASH_Dam1 PF08653.10 PIK44313.1 - 8.9 6.2 10.9 0.91 9.4 0.5 4.6 4 1 1 5 5 5 0 DASH complex subunit Dam1 DUF5407 PF17401.2 PIK44313.1 - 9.1 6.6 8.4 11 6.4 0.5 3.8 2 2 2 4 4 4 0 Family of unknown function (DUF5407) Zip PF02535.22 PIK44314.1 - 3.3e-54 184.3 9.6 4e-54 184.1 9.6 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Phage_holin_3_6 PF07332.11 PIK44314.1 - 0.0063 16.5 7.4 1.3 9.1 0.0 4.1 3 2 1 4 4 4 2 Putative Actinobacterial Holin-X, holin superfamily III Carb_kinase PF01256.17 PIK44315.1 - 3.2e-49 167.6 0.0 3.9e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 PIK44315.1 - 0.0097 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Kelch_4 PF13418.6 PIK44315.1 - 0.042 13.9 0.1 11 6.1 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Phos_pyr_kin PF08543.12 PIK44315.1 - 0.047 13.1 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Pan3_PK PF18101.1 PIK44316.1 - 7.9e-38 129.6 0.0 1.3e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 PIK44316.1 - 0.00024 20.6 0.0 0.0076 15.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain 3Beta_HSD PF01073.19 PIK44317.1 - 2.7e-65 220.2 0.0 3.3e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK44317.1 - 1.1e-35 123.3 0.0 1.3e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK44317.1 - 1.8e-17 63.8 0.0 8.6e-17 61.5 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 PIK44317.1 - 1.6e-13 51.0 0.0 2.1e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 PIK44317.1 - 4.3e-09 35.9 0.0 6.2e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 PIK44317.1 - 4.6e-08 32.6 0.1 3.4e-05 23.1 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein NmrA PF05368.13 PIK44317.1 - 3.3e-06 26.8 0.0 7.7e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 PIK44317.1 - 0.00025 20.3 0.0 0.0005 19.3 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK44317.1 - 0.033 14.1 0.0 5.1 7.0 0.0 2.3 2 0 0 2 2 2 0 KR domain BEN PF10523.9 PIK44318.1 - 1.6e-11 44.2 0.2 4.5e-11 42.8 0.2 1.8 1 0 0 1 1 1 1 BEN domain HTH_32 PF13565.6 PIK44318.1 - 2.1e-06 28.3 0.8 2.3e-05 24.9 0.0 2.8 2 1 1 3 3 3 1 Homeodomain-like domain PAX PF00292.18 PIK44318.1 - 0.046 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 'Paired box' domain Ribosomal_L30 PF00327.20 PIK44319.1 - 2e-12 46.8 1.1 3.7e-12 46.0 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ASC PF00858.24 PIK44320.1 - 3.3e-51 174.7 0.1 4.1e-51 174.3 0.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel GATase_5 PF13507.6 PIK44321.1 - 2.2e-95 318.7 1.7 4.2e-94 314.5 1.7 2.2 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 PIK44321.1 - 1.6e-39 135.5 2.1 5.1e-22 78.7 0.2 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 PIK44321.1 - 3.6e-15 55.9 0.0 7.7e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 PIK44321.1 - 1.1e-11 45.0 0.0 4.5e-11 43.1 0.0 2.1 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain zf-MYND PF01753.18 PIK44323.1 - 9.4e-10 38.4 10.3 1.9e-09 37.5 10.3 1.5 1 0 0 1 1 1 1 MYND finger ubiquitin PF00240.23 PIK44323.1 - 0.012 15.3 0.1 0.024 14.4 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin family Ubiquitin_5 PF18037.1 PIK44323.1 - 0.023 15.1 0.6 0.057 13.8 0.6 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain zf-C6H2 PF15801.5 PIK44323.1 - 0.45 10.9 8.7 1.1 9.6 8.7 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding MAT1 PF06391.13 PIK44324.1 - 0.32 10.8 6.6 2.3 8.0 4.6 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 LIM PF00412.22 PIK44324.1 - 0.57 10.5 3.7 8.3 6.7 3.4 2.3 1 1 0 1 1 1 0 LIM domain SNF2_N PF00176.23 PIK44326.1 - 2.5e-28 98.8 0.0 4.4e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HARP PF07443.13 PIK44326.1 - 1.4e-17 63.1 0.1 3.5e-17 61.8 0.1 1.7 1 0 0 1 1 1 1 HepA-related protein (HARP) Helicase_C PF00271.31 PIK44326.1 - 2.8e-14 53.4 0.1 5.4e-13 49.2 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK44326.1 - 3.6e-05 23.8 0.0 0.00082 19.4 0.0 3.0 2 2 0 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 PIK44326.1 - 0.023 14.7 0.0 0.083 12.9 0.0 1.9 1 0 0 1 1 1 0 Flavivirus DEAD domain CmlA_N PF18456.1 PIK44326.1 - 0.25 10.6 0.9 0.69 9.2 0.0 2.1 3 0 0 3 3 3 0 Diiron non-heme beta-hydroxylase N-terminal domain Acetyltransf_2 PF00797.17 PIK44327.1 - 0.0026 17.6 0.1 0.055 13.2 0.0 2.5 2 1 0 2 2 2 1 N-acetyltransferase Sulfotransfer_1 PF00685.27 PIK44327.1 - 0.055 12.9 0.6 0.3 10.5 0.1 2.0 2 0 0 2 2 2 0 Sulfotransferase domain Acetyltransf_2 PF00797.17 PIK44329.1 - 1.1e-05 25.4 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase RT_RNaseH_2 PF17919.1 PIK44330.1 - 4.7e-32 110.0 0.0 1.1e-31 108.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44330.1 - 1.2e-29 102.6 0.0 9.5e-29 99.8 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK44330.1 - 4.3e-10 39.6 0.0 9.3e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK44330.1 - 0.042 14.1 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger RVT_1 PF00078.27 PIK44331.1 - 9.5e-25 87.4 0.0 1.4e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_6 PF15288.6 PIK44333.1 - 0.00083 19.2 1.1 0.0017 18.1 1.1 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK44333.1 - 0.0027 17.7 2.9 0.0044 17.0 2.9 1.4 1 0 0 1 1 1 1 Zinc knuckle DUF86 PF01934.17 PIK44333.1 - 0.014 15.2 0.3 0.032 14.1 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF86 RT_RNaseH_2 PF17919.1 PIK44334.1 - 9.2e-10 38.5 0.1 2.2e-09 37.3 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK44335.1 - 1.8e-10 40.8 1.5 2.4e-10 40.4 0.0 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK44336.1 - 1.9e-05 24.5 1.2 2.7e-05 24.0 1.2 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK44336.1 - 0.0017 18.0 1.6 0.0034 17.1 1.6 1.5 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK44336.1 - 0.011 15.7 0.4 0.02 14.8 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle BAR_3 PF16746.5 PIK44336.1 - 0.03 14.0 0.1 0.036 13.8 0.1 1.2 1 0 0 1 1 1 0 BAR domain of APPL family zf-CCHC_2 PF13696.6 PIK44336.1 - 0.058 13.2 3.2 0.087 12.7 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-C2HE PF16278.5 PIK44336.1 - 0.075 13.5 0.3 0.15 12.5 0.3 1.7 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger RVT_1 PF00078.27 PIK44337.1 - 4.2e-15 55.9 0.0 4.5e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Radical_SAM PF04055.21 PIK44337.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily rve PF00665.26 PIK44338.1 - 1.2e-24 86.8 0.0 1.6e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44338.1 - 3.2e-19 68.8 3.2 5.3e-19 68.1 3.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44338.1 - 7.9e-06 25.6 0.1 2e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK44338.1 - 0.00018 21.6 0.8 0.00036 20.7 0.8 1.5 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK44339.1 - 2.2e-32 112.4 0.2 2.9e-32 112.0 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ADAM_CR_2 PF17771.1 PIK44340.1 - 4.4e-19 68.8 24.4 1.2e-18 67.4 5.6 4.6 6 1 0 6 6 6 2 ADAM cysteine-rich domain ADAM_spacer1 PF05986.14 PIK44340.1 - 1e-18 67.4 0.0 2.3e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 PIK44340.1 - 9.8e-11 41.7 50.0 5.9e-10 39.2 7.5 5.8 5 1 0 5 5 5 3 Thrombospondin type 1 domain Reprolysin PF01421.19 PIK44340.1 - 1.1e-07 31.9 0.0 2.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 PIK44340.1 - 7.2e-05 23.0 0.1 0.00019 21.7 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 PIK44340.1 - 0.0017 18.2 0.1 0.0035 17.2 0.1 1.4 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 PIK44340.1 - 0.0059 16.3 0.0 0.018 14.7 0.0 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK44340.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK44340.1 - 0.28 10.4 0.4 0.45 9.7 0.4 1.2 1 0 0 1 1 1 0 Met-zincin Pep_M12B_propep PF01562.19 PIK44341.1 - 6.3e-28 97.8 0.2 1.8e-27 96.3 0.1 1.7 2 0 0 2 2 2 1 Reprolysin family propeptide AAA_16 PF13191.6 PIK44342.1 - 0.12 12.7 0.0 0.42 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Sulfotransfer_2 PF03567.14 PIK44343.1 - 5.3e-14 52.7 0.6 6.9e-14 52.4 0.6 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK44343.1 - 6.4e-07 29.1 0.1 1.3e-06 28.1 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 PIK44344.1 - 0.013 15.4 0.1 0.014 15.3 0.1 1.1 1 0 0 1 1 1 0 Sulfotransferase family Ribophorin_I PF04597.14 PIK44347.1 - 1.9e-134 449.2 0.8 2.8e-134 448.7 0.8 1.2 1 0 0 1 1 1 1 Ribophorin I FAD-SLDH PF12318.8 PIK44347.1 - 0.058 13.5 0.8 0.11 12.5 0.8 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase COG2 PF06148.11 PIK44347.1 - 0.095 12.8 1.5 0.65 10.1 0.6 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Bax1-I PF01027.20 PIK44348.1 - 6.7e-49 166.5 27.0 7.6e-49 166.3 27.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 PIK44348.1 - 1.7e-05 24.5 20.8 3e-05 23.7 20.8 1.3 1 1 0 1 1 1 1 Bax inhibitor 1 like DUF2070 PF09843.9 PIK44348.1 - 4.7 5.4 20.8 6.2 5.0 20.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2306 PF10067.9 PIK44348.1 - 7 6.8 12.2 0.84 9.8 5.7 2.4 1 1 2 3 3 3 0 Predicted membrane protein (DUF2306) Peptidase_U4 PF03419.13 PIK44348.1 - 7.6 5.7 17.2 5.1 6.3 15.1 1.7 1 1 1 2 2 2 0 Sporulation factor SpoIIGA PX PF00787.24 PIK44349.1 - 4.1e-18 65.4 0.4 1.2e-17 63.9 0.1 2.0 2 0 0 2 2 2 1 PX domain LRR_4 PF12799.7 PIK44349.1 - 0.0028 18.0 0.3 0.059 13.8 0.0 3.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44349.1 - 0.016 14.7 0.1 0.042 13.3 0.0 1.7 1 1 0 1 1 1 0 Leucine-rich repeat LRR_8 PF13855.6 PIK44349.1 - 0.057 13.2 1.9 0.18 11.6 0.1 2.8 2 1 0 2 2 2 0 Leucine rich repeat Exo_endo_phos PF03372.23 PIK44350.1 - 0.0041 16.7 0.0 3.7 7.0 0.0 2.8 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family WH1 PF00568.23 PIK44351.1 - 9.6e-21 73.8 2.3 9.6e-21 73.8 2.3 2.0 2 0 0 2 2 2 1 WH1 domain WH2 PF02205.20 PIK44351.1 - 6e-11 41.8 0.2 0.00045 19.9 0.0 2.5 2 0 0 2 2 2 2 WH2 motif PBD PF00786.28 PIK44351.1 - 0.015 15.7 1.7 0.015 15.6 0.0 1.9 2 0 0 2 2 2 0 P21-Rho-binding domain Glyco_transf_10 PF00852.19 PIK44352.1 - 7.2e-44 149.6 2.2 9.2e-44 149.2 2.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK44352.1 - 0.00014 22.2 0.1 0.00049 20.5 0.0 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal SecY PF00344.20 PIK44353.1 - 4.3e-32 111.6 0.2 5.3e-32 111.3 0.2 1.1 1 0 0 1 1 1 1 SecY translocase Fumarate_red_C PF02300.17 PIK44353.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Fumarate reductase subunit C SecY PF00344.20 PIK44354.1 - 2e-33 115.9 4.1 3.1e-33 115.4 4.1 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 PIK44354.1 - 1e-18 66.8 2.2 1.1e-18 66.7 0.2 2.1 2 0 0 2 2 2 1 Plug domain of Sec61p DUF2975 PF11188.8 PIK44354.1 - 0.53 10.2 5.5 0.54 10.1 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2975) SdpI PF13630.6 PIK44354.1 - 8.6 6.6 7.4 1.4 9.1 0.2 3.2 2 1 1 3 3 3 0 SdpI/YhfL protein family CLP1_P PF16575.5 PIK44355.1 - 3.1e-25 89.1 0.0 5.8e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop FAM76 PF16046.5 PIK44357.1 - 0.00071 19.0 9.1 0.00071 19.0 9.1 2.6 1 1 1 2 2 2 1 FAM76 protein Myosin_tail_1 PF01576.19 PIK44357.1 - 0.032 12.0 33.6 0.15 9.9 33.6 1.9 1 1 0 1 1 1 0 Myosin tail PKcGMP_CC PF16808.5 PIK44357.1 - 0.13 12.1 11.9 3.9 7.4 0.4 4.4 2 1 2 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YjbH PF06082.11 PIK44357.1 - 0.2 10.4 9.1 0.26 10.1 9.1 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH MAD PF05557.13 PIK44357.1 - 0.42 8.9 33.0 0.065 11.6 13.6 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF641 PF04859.12 PIK44357.1 - 0.64 10.4 28.7 0.17 12.2 1.3 4.2 1 1 3 4 4 4 0 Plant protein of unknown function (DUF641) HMMR_N PF15905.5 PIK44357.1 - 0.98 8.8 37.1 1.3 8.4 21.6 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal UPF0242 PF06785.11 PIK44357.1 - 1.4 9.0 37.5 11 6.0 26.9 3.2 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF5082 PF16888.5 PIK44357.1 - 2.1 8.6 24.2 0.31 11.3 15.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 PIK44357.1 - 2.2 8.3 15.8 0.053 13.5 4.0 2.6 2 1 0 2 2 2 0 Laminin Domain II SlyX PF04102.12 PIK44357.1 - 2.4 8.8 20.6 9.6 6.9 3.2 4.3 1 1 3 4 4 4 0 SlyX Spc29 PF17082.5 PIK44357.1 - 2.6 7.8 17.5 0.11 12.3 4.5 3.0 1 1 2 3 3 3 0 Spindle Pole Component 29 Nup54_57_C PF18570.1 PIK44357.1 - 3.1 7.5 7.2 1.6 8.4 0.2 3.5 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain TMF_DNA_bd PF12329.8 PIK44357.1 - 3.1 7.8 37.7 0.91 9.6 0.3 5.0 2 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding SRCR PF00530.18 PIK44358.1 - 1.9e-25 89.3 21.2 1.6e-11 44.5 0.1 4.8 5 0 0 5 5 5 3 Scavenger receptor cysteine-rich domain Somatomedin_B PF01033.17 PIK44358.1 - 5.7e-11 42.6 41.3 3.9e-07 30.3 14.9 4.4 4 0 0 4 4 4 2 Somatomedin B domain zf_CCCH_5 PF18384.1 PIK44358.1 - 0.58 10.3 5.7 0.24 11.5 0.6 3.2 2 0 0 2 2 2 0 Unkempt Zinc finger domain 1 (Znf1) SLAIN PF15301.6 PIK44359.1 - 0.0036 16.6 24.4 0.0067 15.7 24.4 1.5 1 1 0 1 1 1 1 SLAIN motif-containing family DUF3827 PF12877.7 PIK44359.1 - 3.5 5.9 5.4 4.7 5.5 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) ALG11_N PF15924.5 PIK44360.1 - 2.2e-66 223.9 0.1 2.7e-66 223.6 0.1 1.1 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 PIK44360.1 - 9.3e-10 38.3 0.1 1.7e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 PIK44360.1 - 0.0088 16.0 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Aminotran_1_2 PF00155.21 PIK44361.1 - 9e-12 44.8 0.0 4.5e-09 35.9 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 PIK44361.1 - 0.012 14.1 0.0 0.022 13.3 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme LEM PF03020.15 PIK44362.1 - 7e-13 47.9 0.0 1.3e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 LEM domain Ank_4 PF13637.6 PIK44362.1 - 3.3e-12 46.6 0.0 4e-06 27.3 0.0 2.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK44362.1 - 2.6e-08 34.3 0.0 2.7e-06 27.8 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK44362.1 - 6.4e-07 29.5 0.0 1.8e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK44362.1 - 1.1e-05 25.5 0.1 0.00019 21.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 PIK44362.1 - 0.0019 18.6 0.0 0.016 15.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Cauli_VI PF01693.16 PIK44362.1 - 0.0065 16.8 0.1 0.015 15.6 0.1 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin UvsW PF11637.8 PIK44362.1 - 0.13 12.3 0.7 0.36 10.9 0.7 1.7 1 0 0 1 1 1 0 ATP-dependant DNA helicase UvsW LRRC37 PF15779.5 PIK44362.1 - 0.35 11.3 1.8 0.55 10.6 0.5 1.9 2 0 0 2 2 2 0 Leucine-rich repeat-containing protein 37 family COesterase PF00135.28 PIK44363.1 - 4.2e-79 266.8 0.0 8.5e-79 265.7 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family RhoGAP PF00620.27 PIK44364.1 - 1.3e-42 145.2 0.0 3.2e-42 143.9 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 PIK44364.1 - 1.3e-41 141.3 9.6 1.2e-13 51.4 0.0 6.0 5 0 0 5 5 5 4 PH domain ArfGap PF01412.18 PIK44364.1 - 3.2e-35 120.7 1.9 9.1e-35 119.3 1.9 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SAM_1 PF00536.30 PIK44364.1 - 6.5e-11 42.5 0.0 1.7e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 PIK44364.1 - 1.2e-10 41.8 15.2 0.0011 19.4 0.1 6.4 5 2 0 5 5 5 2 Pleckstrin homology domain SAM_2 PF07647.17 PIK44364.1 - 1e-09 38.4 0.1 2.4e-09 37.1 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 PIK44364.1 - 4.4e-06 27.2 0.0 1.9e-05 25.2 0.0 2.1 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH_9 PF15410.6 PIK44364.1 - 2e-05 25.0 1.7 0.06 13.7 0.0 4.9 4 1 0 4 4 4 1 Pleckstrin homology domain PH_6 PF15406.6 PIK44364.1 - 0.15 12.4 0.1 2.9 8.2 0.0 3.0 4 0 0 4 4 4 0 Pleckstrin homology domain DUF4606 PF15379.6 PIK44365.1 - 2.6e-18 66.1 0.8 2.6e-18 66.1 0.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4606) Peptidase_M24 PF00557.24 PIK44366.1 - 1.9e-56 191.1 0.0 2.5e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 dsrm PF00035.26 PIK44367.1 - 2.6e-19 69.7 0.0 4.4e-09 36.9 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif Helicase_C PF00271.31 PIK44367.1 - 8.6e-15 55.0 0.0 3.1e-14 53.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 PIK44367.1 - 3.6e-14 52.9 0.9 7.1e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK44367.1 - 3.3e-12 46.6 0.0 7.1e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK44367.1 - 0.00062 19.6 0.1 0.0024 17.7 0.1 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase DND1_DSRM PF14709.7 PIK44367.1 - 0.067 13.5 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 Dicer_dimer PF03368.14 PIK44367.1 - 0.17 12.1 0.0 0.56 10.4 0.0 1.9 1 0 0 1 1 1 0 Dicer dimerisation domain PhoH PF02562.16 PIK44367.1 - 0.18 11.2 0.0 0.53 9.7 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein ETF_QO PF05187.13 PIK44369.1 - 7.5e-48 161.0 0.1 1.3e-47 160.2 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 PIK44369.1 - 1.6e-08 34.6 0.6 4.1e-05 23.3 0.2 2.5 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK44369.1 - 1.2e-06 27.9 0.4 0.00044 19.5 0.5 2.2 1 1 1 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 PIK44369.1 - 5.4e-06 26.9 0.1 1.9e-05 25.1 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK44369.1 - 1e-05 25.6 0.0 9e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK44369.1 - 1.1e-05 24.8 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 PIK44369.1 - 5e-05 22.7 0.1 7.4e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK44369.1 - 0.0001 22.3 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 PIK44369.1 - 0.00025 20.2 0.1 0.00036 19.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 PIK44369.1 - 0.00048 19.5 0.1 0.00083 18.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 PIK44369.1 - 0.0015 17.3 0.1 0.0027 16.5 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 PIK44369.1 - 0.0016 17.7 0.1 0.0024 17.2 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 PIK44369.1 - 0.015 14.2 1.1 0.11 11.3 0.2 2.5 2 1 1 3 3 3 0 Tryptophan halogenase K_oxygenase PF13434.6 PIK44369.1 - 0.024 13.8 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Fer4_7 PF12838.7 PIK44369.1 - 0.044 14.4 1.1 0.11 13.2 1.1 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fibrillarin_2 PF10113.9 PIK44370.1 - 0.13 10.8 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein SNF PF00209.18 PIK44372.1 - 2.4e-43 148.6 29.6 3e-43 148.3 29.6 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF1449 PF07290.11 PIK44372.1 - 5.3 6.6 7.9 22 4.6 7.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1449) CLASP_N PF12348.8 PIK44373.1 - 0.0089 15.6 0.0 0.034 13.7 0.0 1.8 1 1 0 1 1 1 1 CLASP N terminal Soyouz_module PF14313.6 PIK44373.1 - 0.03 14.1 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) zf_UBZ PF18439.1 PIK44373.1 - 0.15 11.6 3.1 0.4 10.3 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 PIK44373.1 - 0.25 11.7 3.7 0.72 10.2 3.7 1.8 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-ACC PF17848.1 PIK44373.1 - 0.96 9.6 5.3 23 5.2 1.5 2.9 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-TFIIB PF13453.6 PIK44373.1 - 4.4 6.7 6.5 16 4.9 0.7 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger End3 PF12761.7 PIK44373.1 - 9.4 6.3 10.6 2 8.5 2.8 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 FimH_man-bind PF09160.10 PIK44374.1 - 0.00019 21.1 10.1 0.84 9.3 0.1 4.3 2 2 1 3 3 3 3 FimH, mannose binding C2-set_2 PF08205.12 PIK44375.1 - 0.016 15.3 0.4 0.81 9.8 0.0 2.9 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK44375.1 - 0.017 15.2 0.3 0.077 13.1 0.0 2.3 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK44375.1 - 0.25 12.0 6.8 1.8 9.2 0.0 3.8 3 1 0 3 3 3 0 Immunoglobulin domain EamA PF00892.20 PIK44376.1 - 6.8e-24 84.6 27.8 4.1e-15 56.2 9.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family LRR19-TM PF15176.6 PIK44376.1 - 0.27 11.2 1.5 0.6 10.1 1.5 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain MNE1 PF13762.6 PIK44376.1 - 0.3 11.1 4.5 0.19 11.7 0.9 2.2 2 1 0 2 2 2 0 Mitochondrial splicing apparatus component ZU5 PF00791.20 PIK44377.1 - 2.8e-14 53.2 0.1 6.2e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain L_protein_N PF15518.6 PIK44378.1 - 3.5e-06 26.8 0.1 0.24 11.3 0.0 5.1 2 2 4 6 6 6 2 L protein N-terminus Protamine_P2 PF00841.19 PIK44378.1 - 0.28 11.7 2.4 94 3.6 0.1 3.8 2 2 2 4 4 4 0 Sperm histone P2 PHD_4 PF16866.5 PIK44379.1 - 0.012 15.7 0.3 0.22 11.6 0.1 2.8 2 0 0 2 2 2 0 PHD-finger RGS PF00615.19 PIK44379.1 - 0.022 15.0 0.4 1.6 9.0 0.1 2.7 2 0 0 2 2 2 0 Regulator of G protein signaling domain CopG_antitoxin PF12441.8 PIK44379.1 - 0.12 12.9 0.0 0.46 11.1 0.0 2.0 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system fn3 PF00041.21 PIK44380.1 - 1.2e-30 105.7 13.7 7.5e-11 42.2 0.1 4.8 3 1 1 4 4 4 4 Fibronectin type III domain I-set PF07679.16 PIK44380.1 - 9.2e-11 41.7 0.7 0.00073 19.5 0.0 3.8 3 1 1 4 4 4 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK44380.1 - 9.5e-08 32.5 1.8 0.024 15.2 0.0 3.6 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK44380.1 - 4e-06 26.9 0.4 0.032 14.4 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK44380.1 - 2.5e-05 24.8 8.9 0.16 12.6 0.1 4.6 2 2 1 3 3 3 2 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 PIK44380.1 - 4.4e-05 23.8 56.1 9.5e-05 22.7 7.7 4.7 5 0 0 5 5 5 2 EGF-like domain hEGF PF12661.7 PIK44380.1 - 0.00013 22.5 6.3 0.00013 22.5 6.3 4.5 3 1 0 3 3 3 1 Human growth factor-like EGF V-set PF07686.17 PIK44380.1 - 0.0036 17.5 0.3 24 5.2 0.0 4.3 3 1 1 4 4 4 0 Immunoglobulin V-set domain DSL PF01414.19 PIK44380.1 - 0.25 11.6 47.7 0.3 11.4 13.6 3.8 3 0 0 3 3 3 0 Delta serrate ligand Laminin_EGF PF00053.24 PIK44380.1 - 0.47 10.6 43.3 27 5.0 15.2 4.0 1 1 2 3 3 3 0 Laminin EGF domain EGF PF00008.27 PIK44380.1 - 1 9.7 47.7 0.038 14.3 8.3 4.2 4 1 0 4 4 4 0 EGF-like domain Tnp_P_element PF12017.8 PIK44382.1 - 6.8e-13 48.6 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Transposase protein DUF3496 PF12001.8 PIK44382.1 - 0.11 12.9 3.5 0.2 12.0 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) Ephrin_rec_like PF07699.13 PIK44384.1 - 4.4e-07 29.6 10.4 4.5e-05 23.1 4.2 3.6 2 1 1 3 3 3 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK44384.1 - 0.013 15.4 5.5 0.018 15.0 0.5 2.8 2 1 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 PIK44384.1 - 2.4 8.6 7.3 4.1 7.9 0.0 3.3 3 1 1 4 4 4 0 TNFR/NGFR cysteine-rich region Pkinase_Tyr PF07714.17 PIK44385.1 - 7e-28 97.6 0.0 8.7e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44385.1 - 1.4e-09 37.7 0.0 1.9e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 PIK44386.1 - 3.6e-05 23.7 0.1 0.0074 16.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK44386.1 - 0.00015 22.3 2.4 0.35 11.5 0.3 2.9 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK44386.1 - 0.0052 17.1 0.1 5 7.5 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK44386.1 - 0.007 16.5 0.1 0.15 12.3 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK44386.1 - 0.0084 16.2 0.4 0.22 11.6 0.2 2.6 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF4834 PF16118.5 PIK44387.1 - 0.02 15.8 0.0 0.052 14.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ECSCR PF15820.5 PIK44387.1 - 0.028 14.2 0.1 0.08 12.8 0.1 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Shisa PF13908.6 PIK44387.1 - 0.084 13.1 0.7 0.2 11.9 0.2 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator G6B PF15096.6 PIK44387.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 G6B family Ig_3 PF13927.6 PIK44388.1 - 1.5e-09 38.3 6.1 0.0004 20.9 0.1 4.5 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK44388.1 - 2.3e-07 31.0 0.2 0.018 15.2 0.1 3.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK44388.1 - 1.5e-06 28.1 0.0 0.0052 16.8 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK44388.1 - 2.6e-05 24.5 5.1 0.023 15.0 0.1 3.9 4 0 0 4 4 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK44388.1 - 0.00018 21.5 2.0 0.03 14.4 0.3 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK44388.1 - 0.00051 20.2 0.2 0.16 12.2 0.1 3.6 3 0 0 3 3 3 1 Immunoglobulin domain DUF4834 PF16118.5 PIK44388.1 - 0.01 16.8 0.7 0.01 16.8 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Marek_A PF02124.15 PIK44388.1 - 0.011 15.6 2.0 0.72 9.7 0.1 2.5 2 0 0 2 2 2 0 Marek's disease glycoprotein A EphA2_TM PF14575.6 PIK44388.1 - 0.021 15.7 1.0 0.056 14.3 0.1 2.1 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Connexin PF00029.19 PIK44388.1 - 0.025 14.3 0.4 0.025 14.3 0.4 2.3 2 0 0 2 2 2 0 Connexin Chordopox_A13L PF05961.11 PIK44388.1 - 0.027 14.7 1.5 0.12 12.6 1.5 2.2 1 0 0 1 1 1 0 Chordopoxvirus A13L protein NB PF04159.13 PIK44388.1 - 0.03 14.4 3.7 0.032 14.3 0.7 2.5 2 0 0 2 2 2 0 NB glycoprotein Sigma_reg_N PF13800.6 PIK44388.1 - 0.081 13.2 0.5 0.27 11.5 0.5 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ECSCR PF15820.5 PIK44388.1 - 0.35 10.7 4.3 0.1 12.4 0.5 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator BUD22 PF09073.10 PIK44388.1 - 4.3 6.6 30.0 8.7 5.6 0.1 2.3 2 0 0 2 2 2 0 BUD22 HTH_Tnp_IS630 PF01710.16 PIK44388.1 - 4.4 7.4 11.7 1.8 8.6 2.8 3.1 2 1 0 2 2 2 0 Transposase V_ATPase_I PF01496.19 PIK44388.1 - 5 4.9 13.7 0.6 8.0 0.6 2.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Phage_holin_6_1 PF09682.10 PIK44388.1 - 7.7 7.0 11.5 0.48 10.9 4.7 2.6 2 0 0 2 2 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) PDDEXK_2 PF12784.7 PIK44389.1 - 0.065 12.8 6.7 0.69 9.4 1.0 2.3 2 0 0 2 2 2 0 PD-(D/E)XK nuclease family transposase Bromo_TP PF07524.13 PIK44389.1 - 0.12 12.3 0.0 3.1 7.9 0.0 2.4 2 1 0 2 2 2 0 Bromodomain associated APG17 PF04108.12 PIK44389.1 - 0.16 11.1 7.2 0.26 10.3 1.1 2.3 1 1 1 2 2 2 0 Autophagy protein Apg17 CobT PF06213.12 PIK44389.1 - 3 7.1 8.5 5.5 6.3 8.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ig_3 PF13927.6 PIK44390.1 - 1.4e-07 32.0 8.4 0.0014 19.2 0.1 4.3 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK44390.1 - 1.3e-06 28.4 0.1 0.021 14.9 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK44390.1 - 5.6e-05 23.3 1.0 0.3 11.3 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin V-set domain DUF4489 PF14879.6 PIK44390.1 - 0.00011 22.4 1.6 0.00035 20.7 1.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4489) C2-set_2 PF08205.12 PIK44390.1 - 0.0037 17.3 2.8 0.86 9.7 0.4 2.9 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK44390.1 - 0.046 13.9 1.0 9.6 6.5 0.0 3.6 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK44390.1 - 0.11 12.9 12.4 0.14 12.5 0.2 4.0 4 1 1 5 5 5 0 Immunoglobulin domain DUF1040 PF06288.13 PIK44390.1 - 0.38 11.2 2.6 0.44 11.0 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1040) SCAN PF02023.17 PIK44391.1 - 2.2e-08 33.8 0.1 6.5e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 SCAN domain Pkinase_Tyr PF07714.17 PIK44392.1 - 4e-06 26.3 0.0 4.7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44392.1 - 0.0072 15.7 0.1 0.014 14.7 0.1 1.5 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44393.1 - 3e-25 89.0 0.0 4.5e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44393.1 - 8.5e-15 54.8 0.0 1.3e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK44393.1 - 1.2e-06 29.0 1.3 0.0007 20.1 0.2 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK44393.1 - 0.0027 17.7 0.1 0.011 15.8 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK44393.1 - 0.0055 16.9 0.6 0.019 15.1 0.6 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRC37AB_C PF14914.6 PIK44393.1 - 0.022 14.7 0.1 0.048 13.6 0.1 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain ig PF00047.25 PIK44393.1 - 0.037 14.2 0.5 0.11 12.7 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain DUF1751 PF08551.10 PIK44394.1 - 1.5e-24 86.4 7.4 1.5e-24 86.4 7.4 1.8 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 PIK44394.1 - 0.00028 20.9 12.5 0.00059 19.9 12.5 1.5 1 0 0 1 1 1 1 Rhomboid family AIRS_C PF02769.22 PIK44395.1 - 5.3e-24 85.1 0.0 7.7e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 PIK44395.1 - 2.3e-10 41.0 0.4 1e-09 38.9 0.1 2.2 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 PIK44396.1 - 2.1e-15 57.2 0.0 2.4e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 PIK44397.1 - 9e-05 23.1 0.0 0.00011 22.7 0.0 1.1 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain MARVEL PF01284.23 PIK44398.1 - 9.9e-29 100.2 13.0 1.2e-28 99.9 13.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain DHHC PF01529.20 PIK44398.1 - 0.45 10.6 10.8 0.17 12.0 6.2 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase YqzM PF14141.6 PIK44398.1 - 8.1 6.6 9.8 2.4 8.2 1.7 2.7 2 0 0 2 2 2 0 YqzM-like protein E1_dh PF00676.20 PIK44399.1 - 3.5e-121 403.8 0.2 4.3e-121 403.5 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 PIK44399.1 - 5.3e-05 22.6 0.5 9.6e-05 21.7 0.0 1.6 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 PIK44399.1 - 0.0023 17.7 0.8 0.0023 17.7 0.8 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain G-alpha PF00503.20 PIK44400.1 - 6.4e-104 347.9 12.0 7.4e-104 347.7 12.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK44400.1 - 4.1e-17 62.2 1.3 4.1e-12 45.9 0.2 2.7 2 1 1 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK44400.1 - 0.00018 21.0 2.5 0.0074 15.7 0.8 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 PIK44400.1 - 0.0011 19.1 0.9 2.3 8.4 0.0 3.2 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK44400.1 - 0.0015 18.6 0.0 0.57 10.3 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase SRPRB PF09439.10 PIK44400.1 - 0.017 14.6 0.5 0.46 9.9 0.1 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 PIK44400.1 - 0.036 13.8 0.0 0.091 12.5 0.0 1.6 1 1 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 PIK44400.1 - 0.041 13.2 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ras PF00071.22 PIK44400.1 - 0.1 12.2 0.8 9.3 5.8 0.1 2.6 2 1 0 2 2 2 0 Ras family Sigma54_activat PF00158.26 PIK44400.1 - 0.11 12.2 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 PIK44400.1 - 0.15 12.0 0.2 12 5.8 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase DDDD PF10161.9 PIK44401.1 - 6.5e-26 89.9 0.0 7.6e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 Putative mitochondrial precursor protein Peptidase_M3 PF01432.20 PIK44402.1 - 7.7e-119 397.9 0.2 1.1e-118 397.4 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M3 Sipho_Gp157 PF05565.11 PIK44402.1 - 0.0055 16.7 0.3 1.9 8.5 0.0 2.5 2 0 0 2 2 2 2 Siphovirus Gp157 Peptidase_M50B PF13398.6 PIK44402.1 - 0.09 12.4 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like Shugoshin_C PF07557.11 PIK44402.1 - 1.3 8.9 5.1 0.2 11.5 0.5 2.1 3 0 0 3 3 3 0 Shugoshin C terminus BEN PF10523.9 PIK44403.1 - 1.7e-06 28.1 0.0 5.6e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 BEN domain Macoilin PF09726.9 PIK44403.1 - 0.0015 17.2 6.4 0.0019 16.8 6.4 1.1 1 0 0 1 1 1 1 Macoilin family FlaC_arch PF05377.11 PIK44403.1 - 0.0016 18.8 2.7 0.0055 17.1 2.7 2.0 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) Ferritin PF00210.24 PIK44403.1 - 0.0022 17.9 5.0 0.0038 17.2 4.3 1.6 2 0 0 2 2 2 1 Ferritin-like domain UPF0242 PF06785.11 PIK44403.1 - 0.011 15.8 9.1 0.017 15.2 9.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mce4_CUP1 PF11887.8 PIK44403.1 - 0.014 14.9 2.9 0.022 14.2 2.9 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative zf-C4H2 PF10146.9 PIK44403.1 - 0.016 15.5 3.4 0.027 14.8 3.4 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein OmpH PF03938.14 PIK44403.1 - 0.023 15.0 5.3 0.059 13.7 5.3 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3287 PF11690.8 PIK44403.1 - 0.042 13.6 0.4 0.1 12.3 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) P4Ha_N PF08336.11 PIK44403.1 - 0.51 10.3 6.9 0.32 11.0 4.4 1.9 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Csm2_III-A PF03750.13 PIK44403.1 - 1.7 9.5 5.6 0.65 10.9 0.8 2.5 2 1 1 3 3 2 0 Csm2 Type III-A CSN5_C PF18323.1 PIK44403.1 - 5.6 8.0 10.9 3.2 8.7 0.7 2.4 1 1 1 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain EMP24_GP25L PF01105.24 PIK44403.1 - 6.5 6.7 8.8 0.78 9.6 3.0 2.3 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD MAD PF05557.13 PIK44404.1 - 3.8e-78 263.5 62.0 9.9e-61 206.0 14.8 2.1 1 1 1 2 2 2 2 Mitotic checkpoint protein Rab5-bind PF09311.11 PIK44404.1 - 0.028 13.8 50.9 0.036 13.5 20.1 3.3 2 1 1 3 3 3 0 Rabaptin-like protein Wbp11 PF09429.10 PIK44405.1 - 1.9e-19 69.9 13.2 1.9e-19 69.9 13.2 3.3 3 1 0 3 3 3 2 WW domain binding protein 11 Forkhead PF00250.18 PIK44406.1 - 1.2e-36 124.8 0.6 2.1e-36 124.0 0.6 1.4 1 0 0 1 1 1 1 Forkhead domain AP3D1 PF06375.11 PIK44406.1 - 0.21 11.8 6.5 0.46 10.7 6.5 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Annexin PF00191.20 PIK44407.1 - 2.4e-78 258.2 7.2 4.2e-26 90.8 0.3 4.0 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 PIK44407.1 - 0.026 14.4 0.3 11 6.0 0.1 2.8 3 0 0 3 3 3 0 Myb DNA-binding like MU117 PF15474.6 PIK44407.1 - 0.043 14.6 0.5 0.081 13.7 0.5 1.5 1 0 0 1 1 1 0 Meiotically up-regulated gene family C2 PF00168.30 PIK44409.1 - 3.5e-16 59.4 1.9 2.9e-14 53.2 0.7 3.6 2 1 0 2 2 2 1 C2 domain C2 PF00168.30 PIK44410.1 - 2.2e-17 63.2 0.0 6.1e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 PIK44410.1 - 1.3e-10 41.6 3.6 0.00022 21.4 1.3 2.8 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain PhoPQ_related PF10142.9 PIK44411.1 - 9.4e-104 347.0 2.5 1.1e-103 346.7 2.5 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein PhoPQ_related PF10142.9 PIK44412.1 - 7.2e-75 251.9 0.2 8.9e-75 251.6 0.2 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein PhoPQ_related PF10142.9 PIK44413.1 - 1.2e-101 340.1 0.1 1.4e-101 339.8 0.1 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein AXE1 PF05448.12 PIK44413.1 - 0.0058 15.3 0.0 0.009 14.7 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) PhoPQ_related PF10142.9 PIK44414.1 - 3.3e-92 309.0 0.1 3.9e-92 308.7 0.1 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein AXE1 PF05448.12 PIK44414.1 - 0.00078 18.2 0.0 0.0012 17.6 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Glycos_transf_1 PF00534.20 PIK44415.1 - 1.5e-12 47.4 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK44415.1 - 3.3e-10 40.5 0.0 4.7e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 PIK44415.1 - 0.00011 22.5 0.0 0.00021 21.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 PIK44415.1 - 0.0018 18.7 0.0 0.0029 18.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 PIK44415.1 - 0.0058 16.6 0.1 0.0096 15.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Mito_carr PF00153.27 PIK44416.1 - 9e-42 140.9 0.8 3.7e-19 68.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IBR PF01485.21 PIK44417.1 - 8.7e-06 25.9 29.4 0.00011 22.3 8.9 4.5 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain HlyIII PF03006.20 PIK44419.1 - 5.3e-17 62.3 15.7 6.6e-17 62.0 15.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related NapE PF06796.11 PIK44419.1 - 0.0025 17.3 5.5 0.3 10.6 3.3 3.0 2 0 0 2 2 2 2 Periplasmic nitrate reductase protein NapE Ceramidase PF05875.12 PIK44419.1 - 0.14 11.5 10.6 1.7 8.0 0.6 2.2 2 0 0 2 2 2 0 Ceramidase RA PF00788.23 PIK44420.1 - 0.0008 20.0 0.0 0.071 13.8 0.0 2.3 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain Thioredoxin_8 PF13905.6 PIK44421.1 - 1.3e-23 83.1 0.0 1.6e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 PIK44421.1 - 1.8e-07 31.1 0.0 2.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 PIK44421.1 - 4.2e-06 26.7 0.0 4.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 PIK44421.1 - 3.7e-05 23.5 0.0 4.3e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 PIK44421.1 - 0.015 15.7 0.0 0.018 15.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF4200 PF13863.6 PIK44422.1 - 2.1e-35 121.7 24.7 2.1e-35 121.7 24.7 3.3 2 1 0 3 3 3 1 Domain of unknown function (DUF4200) bZIP_1 PF00170.21 PIK44422.1 - 0.64 10.2 16.3 1.8 8.7 2.2 3.7 3 0 0 3 3 3 0 bZIP transcription factor CCP_MauG PF03150.14 PIK44422.1 - 0.65 10.6 3.8 1 10.0 0.2 2.4 1 1 2 3 3 3 0 Di-haem cytochrome c peroxidase GIDA_assoc PF13932.6 PIK44422.1 - 1.2 9.3 23.5 1.5 8.9 13.1 2.2 1 1 0 2 2 2 0 GidA associated domain DUF3450 PF11932.8 PIK44422.1 - 2 7.7 27.2 0.36 10.1 2.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 PIK44422.1 - 2 8.5 32.3 0.12 12.4 12.2 3.1 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein YnfE PF17452.2 PIK44422.1 - 2.9 8.2 13.7 6.2 7.2 0.4 3.5 2 1 1 4 4 4 0 Uncharacterized YnfE-like Prefoldin_2 PF01920.20 PIK44422.1 - 5.7 7.0 31.4 0.71 9.9 6.8 4.6 3 1 0 4 4 4 0 Prefoldin subunit C8 PF08742.11 PIK44423.1 - 3.1e-31 107.6 12.8 1.3e-17 64.0 2.5 4.4 4 0 0 4 4 4 2 C8 domain Methyltransf_FA PF12248.8 PIK44423.1 - 9.2e-30 103.0 0.0 3.1e-27 94.9 0.0 2.4 2 0 0 2 2 2 1 Farnesoic acid 0-methyl transferase VWD PF00094.25 PIK44423.1 - 4.3e-29 101.8 0.7 1.3e-28 100.3 0.4 1.9 2 0 0 2 2 2 1 von Willebrand factor type D domain IgGFc_binding PF17517.2 PIK44423.1 - 3.5e-24 85.6 0.1 1e-23 84.1 0.0 1.8 2 0 0 2 2 2 1 IgGFc binding protein TIL PF01826.17 PIK44423.1 - 3.4e-18 65.6 40.1 3.1e-11 43.3 16.2 7.1 5 2 2 7 7 7 2 Trypsin Inhibitor like cysteine rich domain Lectin_C PF00059.21 PIK44423.1 - 4.3e-14 53.1 0.4 2.5e-06 28.2 0.0 2.7 2 0 0 2 2 2 2 Lectin C-type domain TILa PF12714.7 PIK44423.1 - 1.3e-08 34.7 21.9 4.2e-06 26.6 7.1 5.1 2 2 2 4 4 4 2 TILa domain EGF_3 PF12947.7 PIK44423.1 - 4.2e-05 23.7 24.2 0.00055 20.1 10.4 6.4 5 1 1 6 6 6 2 EGF domain cEGF PF12662.7 PIK44423.1 - 0.025 14.5 0.5 0.025 14.5 0.5 7.1 8 0 0 8 8 8 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK44423.1 - 0.087 12.9 40.1 0.16 12.1 9.0 5.0 4 0 0 4 4 4 0 MSP1 EGF domain 1 Rep_fac_C PF08542.11 PIK44424.1 - 1.2e-25 89.7 0.0 2.9e-25 88.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 PIK44424.1 - 6.3e-14 52.5 0.2 1.3e-13 51.5 0.1 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 PIK44424.1 - 2e-12 47.2 0.0 3.9e-11 43.0 0.1 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 PIK44424.1 - 2.4e-06 27.6 0.0 8.7e-06 25.8 0.0 1.8 1 1 1 2 2 2 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 PIK44424.1 - 4.2e-06 26.7 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 PIK44424.1 - 7.3e-06 26.3 0.1 0.029 14.6 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.6 PIK44424.1 - 9e-06 25.8 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK44424.1 - 9.8e-06 26.0 0.0 0.00055 20.4 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 PIK44424.1 - 1.5e-05 24.5 0.0 0.00045 19.7 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 PIK44424.1 - 0.00014 21.7 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK44424.1 - 0.0002 21.7 0.0 0.00034 21.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 PIK44424.1 - 0.0004 20.2 0.0 0.00075 19.3 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 PIK44424.1 - 0.00063 20.3 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK44424.1 - 0.001 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 PIK44424.1 - 0.0021 17.5 0.1 2 7.8 0.1 2.4 1 1 0 2 2 2 2 Bacterial TniB protein AAA_assoc_2 PF16193.5 PIK44424.1 - 0.0045 17.3 0.0 0.014 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain AAA_25 PF13481.6 PIK44424.1 - 0.0052 16.4 0.3 0.025 14.2 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.11 PIK44424.1 - 0.006 16.4 0.0 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 PIK44424.1 - 0.0067 16.2 0.2 0.017 14.9 0.2 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK44424.1 - 0.0077 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DNA_pol3_delta PF06144.13 PIK44424.1 - 0.0081 15.9 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 PIK44424.1 - 0.012 15.7 0.1 0.026 14.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 PIK44424.1 - 0.018 15.4 0.0 0.047 14.1 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 PIK44424.1 - 0.024 15.1 0.1 0.085 13.4 0.1 1.9 1 1 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 PIK44424.1 - 0.026 14.5 0.5 0.18 11.7 0.1 2.3 1 1 0 2 2 2 0 NTPase AAA_28 PF13521.6 PIK44424.1 - 0.035 14.4 0.0 0.056 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 PIK44424.1 - 0.046 12.7 0.1 0.097 11.6 0.1 1.6 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 PIK44424.1 - 0.074 13.0 0.0 0.16 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 PIK44424.1 - 0.085 12.2 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 PIK44424.1 - 0.13 12.0 0.1 0.31 10.7 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_23 PF13476.6 PIK44424.1 - 0.13 12.8 0.1 0.28 11.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 PIK44424.1 - 0.16 11.2 2.4 0.26 10.5 0.2 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CDC45 PF02724.14 PIK44426.1 - 1.3 7.2 5.3 1.4 7.1 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SDP_N PF12278.8 PIK44427.1 - 0.0044 17.2 2.7 0.0046 17.1 2.7 1.2 1 0 0 1 1 1 1 Sex determination protein N terminal DUF3464 PF11947.8 PIK44427.1 - 0.061 13.1 1.3 0.064 13.0 1.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 cwf21 PF08312.12 PIK44428.1 - 1.8e-15 56.8 6.7 3.5e-15 55.9 4.7 2.2 2 0 0 2 2 2 1 cwf21 domain DUF5641 PF18701.1 PIK44429.1 - 1.2e-27 95.9 2.0 3.7e-27 94.3 2.0 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Mpv17_PMP22 PF04117.12 PIK44429.1 - 4.8e-20 71.6 3.8 9.4e-20 70.6 2.8 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family PCB_OB PF17092.5 PIK44429.1 - 0.13 13.1 0.1 0.3 11.9 0.1 1.6 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain Peptidase_A17 PF05380.13 PIK44430.1 - 8.4e-58 195.0 0.0 1.5e-57 194.2 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase RAP1 PF07218.11 PIK44430.1 - 0.014 13.7 0.2 0.021 13.1 0.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DNA_pol_viral_C PF00336.18 PIK44430.1 - 0.099 12.0 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RPN7 PF10602.9 PIK44430.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 gag-asp_proteas PF13975.6 PIK44432.1 - 0.0006 20.3 0.0 0.0019 18.7 0.0 1.9 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK44432.1 - 0.00087 19.9 0.0 0.002 18.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 PIK44432.1 - 0.0086 15.9 0.0 0.018 14.8 0.0 1.6 1 1 0 1 1 1 1 Putative peptidase (DUF1758) zf-CCHC_5 PF14787.6 PIK44432.1 - 0.046 13.4 0.9 0.046 13.4 0.9 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF1759 PF03564.15 PIK44433.1 - 9.5e-06 25.6 0.1 3e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) CDK2AP PF09806.9 PIK44434.1 - 8.5e-11 42.4 11.0 1.2e-10 41.9 0.1 2.2 1 1 0 2 2 2 1 Cyclin-dependent kinase 2-associated protein THAP PF05485.12 PIK44434.1 - 0.0034 18.3 1.1 0.0074 17.2 0.2 1.9 1 1 0 2 2 2 1 THAP domain LIM PF00412.22 PIK44435.1 - 1.1e-35 121.7 26.6 7.9e-18 64.4 4.8 3.6 3 1 0 3 3 3 3 LIM domain Sgf11 PF08209.11 PIK44435.1 - 0.36 10.4 8.0 5.8 6.6 0.1 4.1 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) DUF4428 PF14471.6 PIK44435.1 - 4.7 7.2 13.3 26 4.8 2.5 3.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4428) zf-TRAF PF02176.18 PIK44436.1 - 3.5e-35 120.5 46.7 2.9e-13 50.3 7.9 5.0 2 1 3 5 5 5 4 TRAF-type zinc finger zf-TRAF_2 PF15965.5 PIK44436.1 - 0.00016 22.1 28.7 0.16 12.5 10.0 4.6 1 1 2 3 3 3 3 TRAF-like zinc-finger Sina PF03145.16 PIK44436.1 - 0.016 15.2 5.5 0.016 15.2 5.5 4.1 1 1 3 4 4 4 0 Seven in absentia protein family DM PF00751.18 PIK44436.1 - 0.027 14.4 1.9 0.027 14.4 1.9 4.4 4 0 0 4 4 4 0 DM DNA binding domain DUF3418 PF11898.8 PIK44436.1 - 0.087 11.5 0.0 1.1 7.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3418) DUF2024 PF09630.10 PIK44436.1 - 0.34 10.8 9.3 0.36 10.7 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) TRAF6_Z2 PF18048.1 PIK44436.1 - 0.66 10.1 0.0 0.66 10.1 0.0 4.1 6 0 0 6 6 6 0 TNF receptor-associated factor 6 zinc finger 2 zf-ACC PF17848.1 PIK44436.1 - 0.77 9.9 0.1 0.77 9.9 0.1 3.8 5 0 0 5 5 5 0 Acetyl-coA carboxylase zinc finger domain zf-BED PF02892.15 PIK44436.1 - 4.7 7.3 19.8 9.2 6.4 0.6 5.1 2 1 2 4 4 4 0 BED zinc finger zf_C2HC_14 PF18574.1 PIK44436.1 - 5.3 6.9 18.1 4.3 7.2 0.6 5.0 5 0 0 5 5 5 0 C2HC Zing finger domain DUF1907 PF08925.11 PIK44437.1 - 7.8e-64 215.8 0.0 9.1e-64 215.6 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) DUF1907 PF08925.11 PIK44438.1 - 2.8e-33 115.6 0.0 3.9e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Rad51 PF08423.11 PIK44439.1 - 3.2e-28 98.7 0.1 4.2e-28 98.3 0.1 1.1 1 0 0 1 1 1 1 Rad51 DnaB_C PF03796.15 PIK44439.1 - 2.1e-06 27.2 0.0 7.3e-05 22.2 0.0 2.1 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 PIK44439.1 - 9.9e-06 25.1 0.1 2.1e-05 24.0 0.1 1.6 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 PIK44439.1 - 0.049 13.4 0.0 0.08 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 PIK44439.1 - 0.11 13.1 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain B9-C2 PF07162.11 PIK44440.1 - 4e-37 128.0 0.0 8.9e-37 126.9 0.0 1.6 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein PTS_2-RNA PF01885.16 PIK44441.1 - 5.7e-14 52.6 0.0 6.4e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family LRR_4 PF12799.7 PIK44441.1 - 0.0004 20.7 1.7 0.021 15.3 1.9 2.6 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK44441.1 - 0.01 16.3 1.8 0.5 11.1 0.9 3.3 2 1 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK44441.1 - 0.38 10.9 3.5 5.3 7.4 0.2 3.5 3 1 1 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 PIK44441.1 - 2.3 8.0 5.9 11 5.8 1.8 3.4 3 1 1 4 4 4 0 Leucine rich repeat RRM_1 PF00076.22 PIK44442.1 - 9.3e-41 137.5 0.1 2.7e-19 68.8 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK44442.1 - 4e-11 42.6 0.0 1.3e-05 25.0 0.0 2.7 2 0 0 2 2 2 2 Occluded RNA-recognition motif LSM_int_assoc PF16605.5 PIK44442.1 - 5.1e-09 36.1 0.7 2.1e-08 34.1 0.7 2.2 1 0 0 1 1 1 1 LSM-interacting associated unstructured Lsm_interact PF05391.11 PIK44442.1 - 5.4e-05 22.5 1.7 0.00014 21.3 1.7 1.7 1 0 0 1 1 1 1 Lsm interaction motif TPR_14 PF13428.6 PIK44442.1 - 0.00042 20.9 0.1 20 6.4 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RRM_7 PF16367.5 PIK44442.1 - 0.0017 18.4 0.0 1.3 9.1 0.0 3.2 2 0 0 2 2 2 1 RNA recognition motif RL PF17797.1 PIK44442.1 - 0.0093 15.9 0.1 0.76 9.8 0.1 2.5 2 0 0 2 2 2 1 RL domain RRM_5 PF13893.6 PIK44442.1 - 0.011 15.4 0.0 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 PIK44442.1 - 0.018 15.1 0.0 0.086 12.9 0.0 2.2 1 0 0 1 1 1 0 Limkain b1 RPW8 PF05659.11 PIK44442.1 - 0.067 12.9 0.1 0.49 10.1 0.1 2.5 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Nup35_RRM_2 PF14605.6 PIK44442.1 - 0.18 11.8 0.1 4.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Spem1 PF15670.5 PIK44442.1 - 1.8 8.0 6.9 4.8 6.7 6.9 1.6 1 0 0 1 1 1 0 Spermatid maturation protein 1 mit_SMPDase PF14724.6 PIK44443.1 - 1.9e-28 99.0 0.0 2.2e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase DUF3687 PF12459.8 PIK44443.1 - 0.009 15.5 1.2 0.022 14.3 1.2 1.6 1 0 0 1 1 1 1 D-Ala-teichoic acid biosynthesis protein RVT_1 PF00078.27 PIK44444.1 - 1.4e-05 24.7 0.0 2.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) mit_SMPDase PF14724.6 PIK44445.1 - 2.2e-95 320.3 21.0 1.4e-62 211.8 3.4 4.3 2 1 1 3 3 3 3 Mitochondrial-associated sphingomyelin phosphodiesterase NikR_C PF08753.11 PIK44445.1 - 0.12 12.5 0.1 0.36 11.0 0.1 1.8 1 0 0 1 1 1 0 NikR C terminal nickel binding domain V-set PF07686.17 PIK44446.1 - 0.016 15.4 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain NACHT PF05729.12 PIK44447.1 - 6.2e-05 23.0 0.0 0.00013 21.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK44447.1 - 0.0002 20.6 1.2 0.00073 18.8 0.2 2.1 2 0 0 2 2 2 1 NB-ARC domain ABC_tran PF00005.27 PIK44447.1 - 0.013 16.0 0.0 0.06 13.9 0.0 2.1 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 PIK44447.1 - 0.025 15.0 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 PIK44447.1 - 0.075 13.6 0.1 0.19 12.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.17 PIK44448.1 - 2.2e-08 33.7 0.0 4.1e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase MtrG PF04210.13 PIK44449.1 - 0.026 14.4 0.1 0.068 13.0 0.1 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Cas6b_C PF17262.2 PIK44449.1 - 0.98 9.5 0.0 0.98 9.5 0.0 2.7 3 0 0 3 3 3 0 Cas6b C-terminal domain NACHT PF05729.12 PIK44450.1 - 2.9e-06 27.3 0.0 5.5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK44450.1 - 0.00014 21.1 0.4 0.00034 19.9 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain AAA_14 PF13173.6 PIK44450.1 - 0.00024 21.1 0.2 0.00061 19.8 0.2 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK44450.1 - 0.018 15.4 0.0 0.046 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 PIK44450.1 - 0.022 15.0 0.0 0.046 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK44450.1 - 0.023 15.2 0.2 0.06 13.9 0.2 1.8 1 1 0 1 1 1 0 ABC transporter TRA-1_regulated PF02343.16 PIK44450.1 - 0.024 14.7 0.1 0.093 12.8 0.0 1.9 2 0 0 2 2 2 0 TRA-1 regulated protein R03H10.4 AAA_7 PF12775.7 PIK44450.1 - 0.027 14.0 0.0 0.063 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 PIK44450.1 - 0.039 13.4 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_18 PF13238.6 PIK44450.1 - 0.054 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK44450.1 - 0.054 13.9 0.0 0.17 12.3 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 PIK44450.1 - 0.079 13.0 0.0 0.22 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 PIK44451.1 - 5.9e-10 39.3 0.1 8.3e-10 38.8 0.1 1.2 1 0 0 1 1 1 1 NACHT domain HisK_sensor PF18698.1 PIK44451.1 - 0.0041 17.5 1.6 0.0052 17.2 0.7 1.6 1 1 0 1 1 1 1 Histidine kinase sensor domain AAA PF00004.29 PIK44451.1 - 0.0064 16.9 0.1 0.013 15.9 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF3818 PF12825.7 PIK44451.1 - 0.0068 15.5 2.2 0.011 14.8 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) AAA_22 PF13401.6 PIK44451.1 - 0.023 14.9 0.4 0.15 12.4 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK44451.1 - 0.025 14.2 0.1 0.068 12.7 0.0 1.7 1 1 1 2 2 2 0 AAA domain CobA_CobO_BtuR PF02572.15 PIK44451.1 - 0.028 14.7 0.1 0.051 13.8 0.1 1.4 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP baeRF_family8 PF18851.1 PIK44451.1 - 0.043 13.9 0.1 0.16 12.0 0.1 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 DEAD PF00270.29 PIK44451.1 - 0.13 12.1 0.4 1.4 8.7 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase Lar_N PF09861.9 PIK44451.1 - 0.17 11.0 0.2 1.2 8.3 0.5 2.2 2 1 0 2 2 2 0 Lactate racemase N-terminal domain SPATIAL PF15256.6 PIK44451.1 - 0.27 11.5 2.3 1.2 9.4 0.3 2.2 1 1 1 2 2 2 0 SPATIAL Mito_fiss_reg PF05308.11 PIK44452.1 - 0.066 13.3 3.5 0.074 13.1 3.5 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 PIK44452.1 - 1.1 8.7 4.3 1.4 8.4 4.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal V-set PF07686.17 PIK44454.1 - 3e-18 66.0 0.1 3.5e-08 33.6 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK44454.1 - 1.3e-13 51.4 0.4 0.00092 19.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK44454.1 - 5e-11 42.5 0.4 0.0048 16.9 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK44454.1 - 3.2e-08 33.8 0.4 0.064 13.6 0.0 3.5 2 1 1 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK44454.1 - 3e-07 30.5 0.4 0.021 15.0 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain BPL_C PF02237.17 PIK44454.1 - 0.064 13.2 0.2 17 5.4 0.0 3.1 3 1 0 3 3 3 0 Biotin protein ligase C terminal domain DUF5590 PF17881.1 PIK44454.1 - 0.1 12.7 0.1 6.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5590) V-set PF07686.17 PIK44455.1 - 4.8e-35 120.0 7.8 1.4e-06 28.4 0.0 6.2 6 1 0 6 6 6 5 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK44455.1 - 9.4e-24 83.8 10.1 0.00088 19.8 0.1 6.4 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.25 PIK44455.1 - 2.1e-22 79.1 7.0 4.6e-05 23.5 0.0 6.4 6 1 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 PIK44455.1 - 1e-19 70.4 9.2 0.0049 16.9 0.1 6.1 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK44455.1 - 2.4e-07 31.0 8.5 1.8 8.9 0.2 6.6 5 2 1 6 6 6 3 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK44455.1 - 4.1e-07 29.7 15.2 0.039 13.7 0.5 5.7 6 0 0 6 6 6 2 Adenovirus E3 region protein CR1 DUF4333 PF14230.6 PIK44455.1 - 0.0067 16.6 2.3 21 5.5 0.1 4.7 5 0 0 5 5 5 1 Domain of unknown function (DUF4333) DUF5640 PF18692.1 PIK44455.1 - 0.056 13.5 5.5 6.2 6.9 0.0 4.5 5 0 0 5 5 5 0 Family of unknown function (DUF5640) Pkinase PF00069.25 PIK44456.1 - 1.7e-50 171.9 0.0 7e-50 169.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44456.1 - 3.3e-24 85.6 0.2 4.6e-15 55.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK44456.1 - 7.1e-06 25.2 0.0 9.5e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK44456.1 - 8.2e-05 22.0 0.0 0.0023 17.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK44456.1 - 0.0016 17.8 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK44456.1 - 0.028 14.3 0.4 0.15 12.0 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK44456.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 PIK44456.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_C PF00433.24 PIK44456.1 - 0.16 12.7 1.8 0.28 11.9 0.7 2.0 2 0 0 2 2 2 0 Protein kinase C terminal domain Sulfotransfer_1 PF00685.27 PIK44458.1 - 3.5e-24 85.7 0.0 5.3e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK44458.1 - 3.4e-12 47.2 0.0 1.8e-11 44.9 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase family Orn_Arg_deC_N PF02784.16 PIK44459.1 - 4.2e-50 170.4 0.0 5.6e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 PIK44459.1 - 3.4e-10 40.0 0.0 4.5e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Sec7 PF01369.20 PIK44460.1 - 2.5e-37 128.4 0.2 3.7e-37 127.8 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain DUF5082 PF16888.5 PIK44460.1 - 0.096 13.0 0.4 0.25 11.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) PH_9 PF15410.6 PIK44461.1 - 2.9e-19 69.6 0.4 9e-19 68.0 0.4 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 PIK44461.1 - 6.2e-09 36.3 0.0 1.5e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 PIK44461.1 - 0.13 12.1 0.8 0.56 10.0 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain 60KD_IMP PF02096.20 PIK44462.1 - 1.2e-06 28.5 0.3 2.4e-06 27.6 0.3 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein HU-CCDC81_bac_2 PF18175.1 PIK44462.1 - 0.35 10.8 1.1 14 5.7 0.1 2.5 1 1 1 2 2 2 0 CCDC81-like prokaryotic HU domain 2 DUF3719 PF12516.8 PIK44463.1 - 0.024 14.3 0.0 7.1 6.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) AbiJ_NTD5 PF18865.1 PIK44463.1 - 0.082 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 ERAP1_C PF11838.8 PIK44464.1 - 1.4e-82 277.7 1.4 2.5e-82 277.0 1.4 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 PIK44464.1 - 1.8e-81 272.9 2.1 3.2e-81 272.1 2.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 PIK44464.1 - 5.3e-35 121.3 0.0 1.1e-34 120.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain BSP PF04450.12 PIK44464.1 - 0.0066 16.3 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase of plants and bacteria PRT_C PF08372.10 PIK44464.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal LRR_9 PF14580.6 PIK44465.1 - 2.7e-05 23.8 0.3 4.5e-05 23.0 0.3 1.5 1 1 0 1 1 1 1 Leucine-rich repeat Rab3-GTPase_cat PF13890.6 PIK44467.1 - 0.035 13.7 4.8 0.81 9.3 0.6 2.2 1 1 1 2 2 2 0 Rab3 GTPase-activating protein catalytic subunit Vpu PF00558.19 PIK44467.1 - 0.15 11.9 3.6 6.6 6.6 0.4 2.9 3 0 0 3 3 3 0 Vpu protein TMEM173 PF15009.6 PIK44467.1 - 0.18 11.0 4.8 3.3 6.8 0.5 2.3 1 1 1 2 2 2 0 Transmembrane protein 173 Carbpep_Y_N PF05388.11 PIK44467.1 - 0.18 12.4 1.1 4 8.0 0.2 2.5 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide LsmAD PF06741.13 PIK44467.1 - 0.23 12.1 1.8 4.4 7.9 0.1 2.5 1 1 1 2 2 2 0 LsmAD domain Ald_deCOase PF11266.8 PIK44467.1 - 0.39 10.4 2.1 18 5.0 0.1 2.3 2 0 0 2 2 2 0 Long-chain fatty aldehyde decarbonylase DUF5446 PF17522.2 PIK44467.1 - 0.53 10.5 3.2 20 5.4 0.2 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5446) E2F_CC-MB PF16421.5 PIK44467.1 - 0.58 10.5 5.6 7.9 6.9 0.7 2.5 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain Hist_deacetyl PF00850.19 PIK44467.1 - 1.5 8.2 5.3 11 5.4 1.8 2.0 1 1 1 2 2 2 0 Histone deacetylase domain DUF4298 PF14131.6 PIK44467.1 - 1.5 8.8 5.1 6.8 6.7 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) DUF997 PF06196.12 PIK44468.1 - 0.0012 18.8 0.1 0.0026 17.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF997) TMEM119 PF15724.5 PIK44468.1 - 0.13 12.4 0.3 0.19 11.8 0.3 1.2 1 0 0 1 1 1 0 TMEM119 family VWA_2 PF13519.6 PIK44469.1 - 4e-12 46.7 0.0 8.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK44469.1 - 6e-11 42.9 0.0 8.7e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK44469.1 - 3.5e-07 29.8 0.2 5.4e-07 29.2 0.2 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1194 PF06707.11 PIK44469.1 - 0.037 13.2 0.0 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) vWA-TerF-like PF10138.9 PIK44469.1 - 0.097 12.8 0.0 0.18 11.9 0.0 1.5 1 1 0 1 1 1 0 vWA found in TerF C terminus ParA PF10609.9 PIK44469.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase VWA_3 PF13768.6 PIK44469.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain RVT_1 PF00078.27 PIK44470.1 - 2.9e-29 102.2 0.1 7.8e-29 100.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK44470.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Med18 protein CLCA PF08434.11 PIK44471.1 - 3.1e-57 193.9 0.0 3.8e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Peptidase_M64 PF09471.10 PIK44471.1 - 0.12 11.9 0.1 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 IgA Peptidase M64 Cep57_CLD_2 PF14197.6 PIK44472.1 - 0.038 14.1 4.0 0.12 12.5 4.0 1.9 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 SAS4 PF15460.6 PIK44472.1 - 0.24 11.5 7.7 1.9 8.6 5.0 3.2 2 1 1 3 3 3 0 Something about silencing, SAS, complex subunit 4 Death PF00531.22 PIK44472.1 - 0.3 11.3 0.2 0.3 11.3 0.2 2.8 2 1 1 3 3 3 0 Death domain TipAS PF07739.13 PIK44472.1 - 0.4 11.2 5.8 3 8.4 0.1 2.6 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain TBCA PF02970.16 PIK44472.1 - 0.67 10.3 13.8 0.094 13.1 6.7 2.9 1 1 1 2 2 2 0 Tubulin binding cofactor A Spc24 PF08286.11 PIK44472.1 - 0.86 9.9 9.9 0.47 10.7 6.2 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF3892 PF13031.6 PIK44472.1 - 0.9 10.2 4.4 1.9 9.2 1.3 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3892) DUF883 PF05957.13 PIK44472.1 - 1 10.0 4.5 0.88 10.2 1.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DivIC PF04977.15 PIK44472.1 - 1.2 9.0 11.8 0.93 9.3 9.2 2.2 1 1 1 2 2 2 0 Septum formation initiator zf-Di19 PF05605.12 PIK44473.1 - 0.016 15.5 0.2 0.027 14.8 0.2 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 PIK44473.1 - 0.057 13.9 0.2 0.12 12.9 0.2 1.5 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain DUF728 PF05304.12 PIK44476.1 - 0.017 14.9 0.6 0.017 14.9 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF728) Calici_MSP PF05752.11 PIK44476.1 - 0.34 10.7 3.0 0.68 9.7 2.3 1.8 1 1 0 1 1 1 0 Calicivirus minor structural protein DUF4962 PF16332.5 PIK44476.1 - 0.35 9.3 7.2 0.47 8.9 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) DUF3584 PF12128.8 PIK44476.1 - 0.44 8.0 25.6 0.62 7.5 25.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tmemb_cc2 PF10267.9 PIK44476.1 - 0.45 9.6 24.9 0.082 12.0 3.7 2.4 2 1 1 3 3 3 0 Predicted transmembrane and coiled-coil 2 protein NPV_P10 PF05531.12 PIK44476.1 - 2.9 8.4 7.8 21 5.7 0.3 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4349 PF14257.6 PIK44477.1 - 0.013 14.9 0.4 0.052 13.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Yippee-Mis18 PF03226.14 PIK44478.1 - 0.0032 17.7 0.3 0.0032 17.7 0.3 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Jas PF16135.5 PIK44478.1 - 0.0085 16.2 0.2 0.0092 16.1 0.2 1.1 1 0 0 1 1 1 1 TPL-binding domain in jasmonate signalling PP2C PF00481.21 PIK44479.1 - 1.1e-54 185.8 0.0 1.6e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK44479.1 - 0.012 15.2 0.4 0.065 12.9 0.4 2.2 1 1 0 1 1 1 0 Protein phosphatase 2C WW_FCH_linker PF16623.5 PIK44479.1 - 0.66 10.8 3.4 1.7 9.4 0.1 2.8 3 0 0 3 3 3 0 Unstructured linker region between on GAS7 protein Rep_fac_C PF08542.11 PIK44480.1 - 3.9e-24 84.9 0.1 1.5e-23 83.0 0.0 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 PIK44480.1 - 2.2e-15 57.3 0.0 5.8e-15 55.9 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 PIK44480.1 - 4.6e-15 55.8 0.0 2.5e-10 40.4 0.0 2.5 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 PIK44480.1 - 7.7e-08 32.5 0.1 5.2e-07 29.8 0.0 2.2 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_11 PF13086.6 PIK44480.1 - 9.3e-06 25.6 0.3 0.00022 21.1 0.0 2.4 2 1 1 3 3 2 1 AAA domain AAA_assoc_2 PF16193.5 PIK44480.1 - 9.3e-06 25.9 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 PIK44480.1 - 1.1e-05 25.7 0.4 0.094 13.0 0.0 3.2 1 1 2 3 3 3 2 AAA domain RuvB_N PF05496.12 PIK44480.1 - 5.3e-05 23.0 0.0 0.00012 21.8 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK44480.1 - 0.00016 22.1 0.0 0.00032 21.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.15 PIK44480.1 - 0.00017 21.7 0.0 0.026 14.5 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_24 PF13479.6 PIK44480.1 - 0.00021 21.1 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 PIK44480.1 - 0.00029 20.7 0.1 0.00073 19.4 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 PIK44480.1 - 0.00054 20.0 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK44480.1 - 0.00088 19.6 0.2 0.012 15.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 PIK44480.1 - 0.0015 18.0 0.0 0.12 11.8 0.0 2.7 1 1 1 2 2 2 1 PhoH-like protein DUF815 PF05673.13 PIK44480.1 - 0.0017 17.5 0.0 0.0035 16.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DEAD PF00270.29 PIK44480.1 - 0.0022 17.8 0.1 0.033 14.0 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_7 PF12775.7 PIK44480.1 - 0.0027 17.2 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 PIK44480.1 - 0.0067 16.4 0.1 0.033 14.2 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TniB PF05621.11 PIK44480.1 - 0.0072 15.7 0.0 0.18 11.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_30 PF13604.6 PIK44480.1 - 0.009 15.7 0.7 0.065 12.9 0.0 2.5 3 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 PIK44480.1 - 0.011 15.0 0.0 0.034 13.4 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain Mg_chelatase PF01078.21 PIK44480.1 - 0.032 13.6 0.0 0.38 10.1 0.0 2.4 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI SMC_ScpB PF04079.16 PIK44480.1 - 0.032 13.8 0.1 0.079 12.6 0.1 1.6 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB Thioredoxin_6 PF13848.6 PIK44480.1 - 0.033 14.1 0.1 0.2 11.6 0.0 2.2 3 0 0 3 3 2 0 Thioredoxin-like domain SNF2_N PF00176.23 PIK44480.1 - 0.037 12.8 0.1 0.12 11.1 0.1 1.9 1 1 0 1 1 1 0 SNF2 family N-terminal domain ATPase_2 PF01637.18 PIK44480.1 - 0.047 13.6 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF3802 PF12290.8 PIK44480.1 - 0.067 13.7 0.1 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3802) BSP_II PF05432.11 PIK44481.1 - 0.00064 19.5 2.1 0.00078 19.2 2.1 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) GST_C_2 PF13410.6 PIK44482.1 - 6.2e-09 35.8 0.0 1e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK44482.1 - 7.8e-09 35.6 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK44482.1 - 2e-08 34.5 0.0 9.2e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK44482.1 - 9.8e-06 25.7 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK44482.1 - 5e-05 23.6 0.0 8.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK44482.1 - 0.00064 20.0 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain AAA_assoc_C PF09821.9 PIK44482.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 C-terminal AAA-associated domain Pkinase PF00069.25 PIK44483.1 - 1.4e-73 247.5 0.0 1.9e-73 247.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44483.1 - 1.2e-33 116.5 0.0 1.8e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 PIK44483.1 - 1.2e-14 54.4 0.1 3.2e-14 53.0 0.0 1.8 2 0 0 2 2 2 1 FHA domain Kdo PF06293.14 PIK44483.1 - 0.00066 19.1 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK44483.1 - 0.0011 17.9 0.3 0.0016 17.4 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Yop-YscD_cpl PF16697.5 PIK44483.1 - 0.018 15.4 0.0 0.23 11.8 0.0 2.6 2 1 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 PIK44483.1 - 0.019 13.7 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 PIK44483.1 - 0.029 13.7 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RNA_pol_Rpb4 PF03874.16 PIK44484.1 - 3.3e-20 72.6 2.1 3.3e-20 72.6 2.1 1.9 1 1 1 2 2 2 1 RNA polymerase Rpb4 RNA_pol_3_Rpc31 PF11705.8 PIK44484.1 - 0.028 14.7 7.5 0.03 14.6 7.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DARPP-32 PF05395.12 PIK44484.1 - 0.12 12.5 7.8 0.19 12.0 7.8 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 DUF2076 PF09849.9 PIK44485.1 - 0.0019 18.3 1.0 0.0023 18.0 1.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Mod_r PF07200.13 PIK44486.1 - 9.2e-26 90.7 17.6 1.2e-25 90.3 17.6 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GIT1_C PF12205.8 PIK44486.1 - 0.043 13.9 3.7 0.083 13.0 3.7 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term IMS PF00817.20 PIK44486.1 - 0.065 13.2 0.2 0.086 12.8 0.2 1.3 1 0 0 1 1 1 0 impB/mucB/samB family Par3_HAL_N_term PF12053.8 PIK44486.1 - 0.084 13.1 0.4 0.25 11.6 0.4 1.8 2 0 0 2 2 2 0 N-terminal of Par3 and HAL proteins CTNNB1_binding PF08347.11 PIK44486.1 - 0.55 10.4 4.4 0.7 10.0 4.1 1.4 1 1 0 1 1 1 0 N-terminal CTNNB1 binding DnaJ PF00226.31 PIK44487.1 - 4.8e-23 81.1 0.3 4.8e-23 81.1 0.3 2.3 2 0 0 2 2 2 1 DnaJ domain PUB PF09409.10 PIK44487.1 - 0.09 12.7 0.6 0.2 11.6 0.2 1.9 2 1 0 2 2 2 0 PUB domain ETRAMP PF09716.10 PIK44488.1 - 3.2 7.9 4.8 0.72 10.0 0.8 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) AA_permease_2 PF13520.6 PIK44489.1 - 2.9e-61 207.6 43.2 3.8e-61 207.2 43.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK44489.1 - 6.5e-25 87.7 43.6 1.6e-24 86.4 43.6 1.6 1 1 0 1 1 1 1 Amino acid permease MIP PF00230.20 PIK44490.1 - 4.1e-44 151.0 5.1 5.1e-44 150.7 5.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF3927 PF13064.6 PIK44490.1 - 0.3 11.1 2.2 4.2 7.4 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3927) C2-C2_1 PF11618.8 PIK44491.1 - 2.6e-64 215.5 0.1 1.5e-54 183.9 0.3 3.8 3 0 0 3 3 3 2 First C2 domain of RPGR-interacting protein 1 RPGR1_C PF18111.1 PIK44491.1 - 4.7e-47 160.0 1.8 4.6e-45 153.5 0.0 3.2 3 0 0 3 3 3 2 Retinitis pigmentosa G-protein regulator interacting C-terminal C2 PF00168.30 PIK44491.1 - 3e-08 33.9 0.0 4.8e-07 30.0 0.0 2.6 2 0 0 2 2 2 1 C2 domain Filament PF00038.21 PIK44491.1 - 0.48 10.0 92.5 0.044 13.4 47.4 5.3 2 2 2 5 5 5 0 Intermediate filament protein Pox_A_type_inc PF04508.12 PIK44491.1 - 8.6 6.4 11.0 16 5.5 0.6 4.4 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat HYR PF02494.16 PIK44492.1 - 1.2e-13 51.2 1.3 2.2e-13 50.3 1.3 1.4 1 0 0 1 1 1 1 HYR domain RIFIN PF02009.16 PIK44492.1 - 0.00012 22.0 2.2 0.00016 21.7 2.2 1.1 1 0 0 1 1 1 1 Rifin TMEM154 PF15102.6 PIK44492.1 - 0.0059 16.5 14.4 0.0059 16.5 14.4 1.9 1 1 1 2 2 2 1 TMEM154 protein family DUF4448 PF14610.6 PIK44492.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Amnionless PF14828.6 PIK44492.1 - 0.022 13.6 1.9 0.032 13.1 1.9 1.2 1 0 0 1 1 1 0 Amnionless DUF3675 PF12428.8 PIK44492.1 - 0.023 15.3 2.0 0.039 14.5 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DUF4577 PF15145.6 PIK44492.1 - 0.042 13.9 0.8 0.066 13.2 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) FAM76 PF16046.5 PIK44492.1 - 0.043 13.2 4.3 0.059 12.7 4.3 1.2 1 0 0 1 1 1 0 FAM76 protein Orf78 PF06024.12 PIK44492.1 - 0.045 14.1 8.9 0.14 12.4 8.9 1.8 1 1 0 1 1 1 0 Orf78 (ac78) DUF1180 PF06679.12 PIK44492.1 - 0.054 13.9 3.6 0.11 12.8 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SelP_N PF04592.14 PIK44492.1 - 0.058 12.8 27.3 0.099 12.0 27.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SPX PF03105.19 PIK44492.1 - 0.078 12.9 19.7 0.12 12.3 19.7 1.3 1 1 0 1 1 1 0 SPX domain RAMP PF04901.13 PIK44492.1 - 0.36 10.8 6.0 0.72 9.9 6.0 1.4 1 0 0 1 1 1 0 Receptor activity modifying family Pox_EPC_I2-L1 PF12575.8 PIK44492.1 - 0.49 10.7 3.9 1.3 9.3 3.9 1.7 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF3112 PF11309.8 PIK44492.1 - 0.88 9.0 12.6 1.8 7.9 12.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Plasmodium_Vir PF05795.11 PIK44492.1 - 2.2 7.6 7.0 3.2 7.1 7.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF5383 PF17355.2 PIK44492.1 - 6 7.2 11.7 11 6.5 10.7 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5383) ASFV_J13L PF05568.11 PIK44492.1 - 6.3 6.5 13.1 14 5.3 13.1 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein adh_short PF00106.25 PIK44494.1 - 1.4e-19 70.3 0.1 2.8e-19 69.4 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK44494.1 - 2.9e-10 40.1 0.0 4.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK44494.1 - 0.011 15.7 0.4 0.055 13.4 0.3 2.0 2 0 0 2 2 2 0 KR domain MDD_C PF18376.1 PIK44495.1 - 3.6e-76 255.1 0.3 5e-76 254.6 0.3 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 PIK44495.1 - 8.3e-07 29.2 0.9 1.9e-06 28.0 0.9 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain ATG19_autophagy PF12744.7 PIK44496.1 - 0.011 15.0 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding PrmA PF06325.13 PIK44497.1 - 1.4e-06 28.0 0.0 2.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK44497.1 - 0.00015 21.8 0.1 0.00024 21.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK44497.1 - 0.00035 21.2 0.1 0.001 19.8 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK44497.1 - 0.0028 17.5 0.1 0.0054 16.5 0.1 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 PIK44497.1 - 0.005 16.7 0.0 0.007 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK44497.1 - 0.0059 16.2 0.1 0.011 15.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 PIK44497.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 PIK44497.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Fanconi_A_N PF15865.5 PIK44498.1 - 1.5e-64 218.6 6.4 1.5e-64 218.6 6.4 2.7 3 1 0 3 3 3 1 Fanconi anaemia group A protein N terminus Phage_int_SAM_4 PF13495.6 PIK44499.1 - 0.00039 20.8 0.1 0.00085 19.8 0.1 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK44499.1 - 0.001 19.3 0.2 0.0027 17.9 0.2 1.7 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK44499.1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phage integrase family DUF4687 PF15747.5 PIK44500.1 - 0.067 13.7 1.7 0.12 12.8 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4687) fn3 PF00041.21 PIK44501.1 - 0.00069 19.9 0.1 0.0013 19.0 0.1 1.5 1 1 0 1 1 1 1 Fibronectin type III domain LRR_8 PF13855.6 PIK44503.1 - 7.9e-21 73.6 11.9 1.8e-11 43.7 1.6 3.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_5 PF13306.6 PIK44503.1 - 6.1e-08 32.7 0.4 9.8e-08 32.0 0.4 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44503.1 - 1.9e-05 24.9 12.8 0.0012 19.2 3.0 4.1 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44503.1 - 0.00089 18.8 2.9 0.048 13.2 0.4 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK44503.1 - 0.25 12.0 8.0 60 4.8 0.1 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK44503.1 - 6 7.2 11.1 48 4.4 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 PIK44504.1 - 2.2e-26 91.4 3.6 3.8e-09 36.2 1.8 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 PIK44504.1 - 3e-12 46.6 1.6 6.6e-11 42.3 1.2 2.1 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44504.1 - 2.3e-09 37.4 8.0 0.0058 17.0 3.1 4.6 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44504.1 - 4.7e-07 29.5 1.3 0.00082 18.9 1.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK44504.1 - 0.0035 17.7 7.4 12 6.9 0.4 6.0 7 0 0 7 7 7 1 Leucine Rich Repeat Bcl-2 PF00452.19 PIK44505.1 - 2.7e-05 24.8 0.0 0.00013 22.6 0.0 2.0 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family BID PF06393.11 PIK44505.1 - 0.018 14.6 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 BH3 interacting domain (BID) zf-H2C2_2 PF13465.6 PIK44507.1 - 1.5e-43 145.3 91.3 1.6e-07 31.4 0.6 13.6 13 1 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.26 PIK44507.1 - 5e-39 130.6 114.5 2.1e-05 24.7 2.1 13.4 14 0 0 14 14 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44507.1 - 3.7e-30 102.0 102.7 0.00021 21.8 1.1 13.3 13 0 0 13 13 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK44507.1 - 8.8e-12 44.7 98.2 7.6e-05 22.6 0.4 13.2 13 1 0 13 13 12 8 C2H2-type zinc finger zf-met PF12874.7 PIK44507.1 - 9.8e-11 41.7 92.1 0.00074 19.8 0.2 13.4 14 0 0 14 14 13 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK44507.1 - 3.1e-09 36.9 97.5 0.0015 18.7 0.3 13.1 14 1 0 14 14 13 7 Zinc-finger double-stranded RNA-binding zf-RING_11 PF17123.5 PIK44507.1 - 0.0034 17.1 14.2 12 5.7 0.1 7.2 7 0 0 7 7 7 0 RING-like zinc finger Cys_rich_KTR PF14205.6 PIK44507.1 - 0.022 14.6 0.2 0.11 12.3 0.2 2.4 1 0 0 1 1 1 0 Cysteine-rich KTR RLAN PF14401.6 PIK44507.1 - 0.071 12.8 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain PyrI_C PF02748.15 PIK44507.1 - 0.16 11.9 0.2 0.16 11.9 0.2 8.9 9 2 2 11 11 10 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 PIK44507.1 - 0.27 12.0 49.3 3.8 8.3 1.0 6.8 2 2 4 7 7 7 0 zinc-ribbon family Zn-C2H2_12 PF18112.1 PIK44507.1 - 0.29 11.7 0.0 0.29 11.7 0.0 8.0 9 0 0 9 9 7 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_8 PF15909.5 PIK44507.1 - 1.7 9.0 55.8 0.073 13.4 3.8 6.9 1 1 6 7 7 7 0 C2H2-type zinc ribbon C1_4 PF07975.12 PIK44507.1 - 1.8 8.8 63.3 2.1 8.6 3.7 8.2 4 3 5 9 9 9 0 TFIIH C1-like domain zf-C2H2_9 PF16293.5 PIK44507.1 - 5 7.1 22.8 2.1 8.3 0.1 6.5 7 1 0 7 7 7 0 C2H2 type zinc-finger (1 copy) UPF0728 PF15092.6 PIK44507.1 - 9.2 6.2 7.6 7.8 6.4 0.1 4.1 3 1 1 4 4 4 0 Uncharacterised protein family UPF0728 Linker_histone PF00538.19 PIK44508.1 - 7.3e-21 74.3 0.6 7.3e-21 74.3 0.6 2.7 2 1 1 3 3 3 1 linker histone H1 and H5 family SLC12 PF03522.15 PIK44508.1 - 1.4 7.9 14.4 1.5 7.7 14.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2486 PF10667.9 PIK44508.1 - 2.1 8.5 17.3 2.9 8.0 17.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) SAPS PF04499.15 PIK44508.1 - 2.2 7.0 8.0 2.5 6.8 8.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Atg14 PF10186.9 PIK44508.1 - 7 5.6 15.4 7.5 5.5 15.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_L23 PF00276.20 PIK44509.1 - 1.2e-13 51.2 0.1 1.8e-13 50.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 WD40 PF00400.32 PIK44511.1 - 5.2e-07 30.3 1.7 0.00074 20.3 0.4 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat Linker_histone PF00538.19 PIK44512.1 - 2.9e-21 75.6 0.6 2.9e-21 75.6 0.6 2.7 2 1 1 3 3 3 1 linker histone H1 and H5 family DUF2486 PF10667.9 PIK44512.1 - 0.38 10.9 17.4 0.52 10.5 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) SLC12 PF03522.15 PIK44512.1 - 0.39 9.7 13.6 0.43 9.5 13.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 PIK44512.1 - 2.6 6.7 8.2 3.1 6.5 8.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CUB PF00431.20 PIK44513.1 - 4.8e-56 187.8 0.1 5.5e-25 87.9 0.0 3.4 3 0 0 3 3 3 3 CUB domain FXa_inhibition PF14670.6 PIK44513.1 - 1.6e-08 34.7 13.5 1.6e-08 34.7 13.5 1.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK44513.1 - 2.3e-05 24.5 16.5 6.1e-05 23.1 16.5 1.8 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.7 PIK44513.1 - 4.2e-05 23.4 2.1 8.6e-05 22.4 1.1 2.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF PF00008.27 PIK44513.1 - 0.0006 20.1 11.6 0.00088 19.5 9.0 2.4 2 0 0 2 2 2 1 EGF-like domain EGF_3 PF12947.7 PIK44513.1 - 0.00093 19.3 10.4 0.00093 19.3 10.4 2.1 1 1 0 1 1 1 1 EGF domain CUB_2 PF02408.20 PIK44513.1 - 0.013 15.3 0.1 0.4 10.5 0.0 2.6 2 0 0 2 2 2 0 CUB-like domain hEGF PF12661.7 PIK44513.1 - 0.016 15.8 11.9 0.16 12.6 7.5 3.6 2 1 0 2 2 2 0 Human growth factor-like EGF POPLD PF08170.12 PIK44513.1 - 0.073 13.4 0.4 1.1 9.7 0.2 2.3 2 0 0 2 2 2 0 POPLD (NUC188) domain CUB PF00431.20 PIK44515.1 - 6.4e-33 113.4 0.1 8e-33 113.1 0.1 1.1 1 0 0 1 1 1 1 CUB domain CUB PF00431.20 PIK44516.1 - 1.1e-59 199.5 0.1 3.8e-34 117.3 0.1 2.2 2 0 0 2 2 2 2 CUB domain Astacin PF01400.24 PIK44516.1 - 7e-50 169.3 0.0 1.1e-49 168.7 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 PIK44516.1 - 0.0077 15.9 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK44516.1 - 0.0097 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Matrixin AMP-binding PF00501.28 PIK44518.1 - 8.2e-92 308.0 0.0 1e-91 307.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK44518.1 - 0.012 16.6 0.0 0.043 14.8 0.0 2.0 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Death PF00531.22 PIK44519.1 - 1.8e-08 34.4 0.1 2.8e-08 33.8 0.1 1.3 1 0 0 1 1 1 1 Death domain DASH_Dad3 PF08656.10 PIK44519.1 - 0.15 12.2 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad3 Ank_2 PF12796.7 PIK44520.1 - 3.5e-28 98.0 0.8 4e-13 49.8 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 PIK44520.1 - 3.4e-24 84.2 1.5 0.00049 20.4 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 PIK44520.1 - 2.9e-23 79.4 0.4 0.0017 18.7 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 PIK44520.1 - 9.8e-23 80.2 0.4 8.1e-08 32.7 0.0 4.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK44520.1 - 3.7e-20 71.7 6.2 8.8e-06 25.9 0.0 5.2 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Spt20 PF12090.8 PIK44520.1 - 2.3 7.7 12.4 3.9 7.0 12.4 1.3 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 PIK44520.1 - 3.8 6.3 9.6 5.3 5.8 9.6 1.2 1 0 0 1 1 1 0 Androgen receptor RHD_dimer PF16179.5 PIK44521.1 - 8.3e-40 135.0 0.0 1.1e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 PIK44522.1 - 9.6e-41 139.5 0.1 1.2e-40 139.3 0.1 1.1 1 0 0 1 1 1 1 Rel homology DNA-binding domain Death PF00531.22 PIK44523.1 - 4.6e-07 29.9 0.0 7.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Death domain RHD_DNA_bind PF00554.22 PIK44524.1 - 2.7e-60 203.2 1.0 6.8e-60 201.9 0.0 2.0 2 0 0 2 2 2 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 PIK44524.1 - 2e-37 127.3 3.2 2.1e-37 127.2 0.0 2.2 2 0 0 2 2 2 1 Rel homology dimerisation domain Ank_2 PF12796.7 PIK44524.1 - 1e-33 115.7 7.4 6.8e-11 42.6 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK44524.1 - 2.4e-22 78.7 4.9 3.4e-06 27.2 0.1 5.4 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK44524.1 - 5.1e-21 72.5 4.6 0.00058 20.1 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 PIK44524.1 - 1.7e-20 73.1 1.9 0.00053 20.5 0.0 5.5 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK44524.1 - 1.4e-19 69.6 9.8 0.0001 22.6 0.1 6.3 6 0 0 6 6 6 4 Ankyrin repeat rve PF00665.26 PIK44525.1 - 1.4e-20 73.7 0.1 2.5e-20 72.9 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44525.1 - 2.1e-17 63.0 0.9 5.2e-17 61.7 0.9 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44525.1 - 0.00044 20.0 0.0 0.0011 18.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK44525.1 - 0.0011 19.2 0.0 0.0028 17.8 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK44526.1 - 2.1e-11 43.7 0.0 4e-11 42.8 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) GCV_H PF01597.19 PIK44526.1 - 0.032 14.1 0.2 0.072 13.0 0.2 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein 7tm_1 PF00001.21 PIK44527.1 - 3.3e-54 184.0 17.8 4e-54 183.7 17.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK44527.1 - 1.7e-06 27.6 17.4 2.5e-06 27.1 17.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK44527.1 - 1.8e-06 27.9 13.8 4.3e-06 26.7 13.8 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK44527.1 - 2.1e-05 24.3 15.6 2.1e-05 24.3 15.6 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TMEM52 PF14979.6 PIK44527.1 - 0.53 10.2 2.5 0.48 10.3 0.1 2.3 2 0 0 2 2 2 0 Transmembrane 52 Band_7 PF01145.25 PIK44528.1 - 6.1e-20 72.0 0.2 1.5e-19 70.7 0.0 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family ThiI PF02568.14 PIK44528.1 - 0.0027 17.3 2.5 0.004 16.8 1.4 1.8 1 1 1 2 2 2 1 Thiamine biosynthesis protein (ThiI) Catalase-rel PF06628.12 PIK44528.1 - 0.026 14.7 0.2 0.078 13.2 0.0 1.9 2 0 0 2 2 2 0 Catalase-related immune-responsive DUF2083 PF09856.9 PIK44528.1 - 0.096 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) Herpes_UL52 PF03121.15 PIK44529.1 - 1.1e-12 47.7 0.1 2.8e-12 46.4 0.1 1.7 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase PTEN_C2 PF10409.9 PIK44530.1 - 5.3e-31 107.2 5.1 8e-31 106.6 5.1 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 PIK44530.1 - 8.8e-07 28.8 0.1 4.6e-06 26.5 0.1 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK44530.1 - 1.3e-05 24.9 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK44530.1 - 0.00041 20.4 0.0 0.00059 19.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK44530.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate BolA PF01722.18 PIK44531.1 - 3.7e-29 100.8 0.3 4.5e-29 100.5 0.3 1.1 1 0 0 1 1 1 1 BolA-like protein RasGEF PF00617.19 PIK44532.1 - 3.1e-48 164.3 0.5 6.9e-48 163.2 0.5 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 PIK44532.1 - 1.9e-12 47.3 0.2 1.9e-12 47.3 0.2 2.7 3 1 0 3 3 3 1 RasGEF N-terminal motif Retrotrans_gag PF03732.17 PIK44532.1 - 0.0031 17.7 2.2 0.029 14.7 0.1 2.9 3 0 0 3 3 3 1 Retrotransposon gag protein DED PF01335.21 PIK44534.1 - 0.00023 21.4 0.1 0.00039 20.7 0.1 1.3 1 0 0 1 1 1 1 Death effector domain Sucrose_synth PF00862.19 PIK44534.1 - 0.061 11.6 0.0 0.078 11.3 0.0 1.1 1 0 0 1 1 1 0 Sucrose synthase zf-B_box PF00643.24 PIK44536.1 - 0.037 14.2 27.0 0.1 12.7 10.9 2.7 2 0 0 2 2 2 0 B-box zinc finger DUF4680 PF15730.5 PIK44536.1 - 0.14 12.5 0.9 0.33 11.3 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) Prominin PF05478.11 PIK44536.1 - 3.1 5.6 17.8 6 4.7 17.8 1.4 1 1 0 1 1 1 0 Prominin PCI PF01399.27 PIK44537.1 - 2.4e-13 50.5 0.0 7e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 PCI domain Exo_endo_phos PF03372.23 PIK44538.1 - 4.1e-10 39.6 0.0 5.5e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2207 PF09972.9 PIK44538.1 - 0.037 12.8 0.1 0.059 12.1 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2567 PF10821.8 PIK44538.1 - 0.22 11.6 0.6 0.37 10.9 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2567) Sugar_tr PF00083.24 PIK44539.1 - 3.2e-22 79.0 19.2 2.4e-20 72.8 3.3 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK44539.1 - 6.7e-21 74.6 18.2 2.4e-18 66.2 7.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_8 PF13181.6 PIK44540.1 - 2.3e-28 96.0 8.2 4.6e-05 23.3 0.0 8.0 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK44540.1 - 7e-28 95.3 15.4 6.6e-05 22.6 0.1 9.0 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 PIK44540.1 - 7.2e-27 91.3 8.4 0.00026 20.9 0.1 8.7 9 0 0 9 9 8 5 Tetratricopeptide repeat DUF1736 PF08409.11 PIK44540.1 - 3.6e-25 87.7 1.2 3.6e-25 87.7 1.2 2.1 2 0 0 2 2 1 1 Domain of unknown function (DUF1736) TPR_19 PF14559.6 PIK44540.1 - 9.3e-25 86.9 3.7 1.5e-08 35.0 0.2 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK44540.1 - 1e-22 79.5 5.7 2.6e-05 23.8 0.4 7.8 3 2 5 8 8 8 4 TPR repeat TPR_12 PF13424.6 PIK44540.1 - 1.4e-22 79.8 15.4 1.3e-07 31.7 0.3 6.7 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 PIK44540.1 - 9.7e-21 72.6 6.3 0.0069 16.7 0.5 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 PIK44540.1 - 7.6e-18 64.9 1.6 1.3e-06 29.0 0.0 5.2 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK44540.1 - 2.2e-17 61.7 10.0 0.0047 16.9 0.0 7.6 7 1 1 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK44540.1 - 3.7e-15 55.3 3.9 0.021 15.6 0.0 6.9 3 2 4 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 PIK44540.1 - 4.9e-15 55.1 3.9 0.00077 19.9 0.0 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK44540.1 - 9.7e-12 44.4 8.6 0.16 11.8 0.1 6.5 7 0 0 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK44540.1 - 3.8e-10 39.9 6.1 5.6e-06 26.5 0.6 4.1 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK44540.1 - 2.4e-08 34.0 0.1 0.0013 18.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK44540.1 - 8.7e-05 22.0 4.1 0.022 14.2 0.2 3.3 1 1 1 3 3 3 1 MalT-like TPR region TPR_15 PF13429.6 PIK44540.1 - 0.0001 21.6 4.1 0.074 12.2 0.1 3.5 1 1 2 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 PIK44540.1 - 0.00016 21.4 3.2 0.0044 16.7 0.2 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.10 PIK44540.1 - 0.00077 19.1 0.1 0.19 11.4 0.0 2.8 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) NARP1 PF12569.8 PIK44540.1 - 0.00092 18.2 2.5 0.2 10.5 0.3 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 SNAP PF14938.6 PIK44540.1 - 0.001 18.6 3.0 0.056 12.9 0.2 2.8 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP RPN6_N PF18055.1 PIK44540.1 - 0.0027 18.1 0.5 2.9 8.3 0.1 2.9 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain ANAPC5 PF12862.7 PIK44540.1 - 0.011 15.8 1.1 0.79 9.8 0.2 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 Fis1_TPR_C PF14853.6 PIK44540.1 - 0.032 14.3 4.4 3.5 7.8 0.1 5.0 5 1 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 PIK44540.1 - 0.043 14.4 0.0 8.6 7.3 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 PIK44540.1 - 0.11 12.6 5.6 0.21 11.7 0.1 4.2 6 0 0 6 6 3 0 MIT (microtubule interacting and transport) domain TPR_20 PF14561.6 PIK44540.1 - 0.3 11.5 3.4 1.9 8.9 0.1 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 PIK44540.1 - 0.57 10.2 2.2 26 4.9 0.0 3.8 4 2 3 7 7 6 0 Protein of unknown function (DUF627) FGFR3_TM PF18123.1 PIK44540.1 - 1.5 8.4 4.2 0.35 10.4 0.4 1.9 2 0 0 2 2 1 0 Fibroblast growth factor receptor 3 transmembrane domain DUF4246 PF14033.6 PIK44542.1 - 0.0016 17.6 5.3 0.27 10.3 5.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF4246) TPR_2 PF07719.17 PIK44543.1 - 8.1e-20 69.3 1.2 5.9e-07 29.1 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK44543.1 - 1.7e-16 60.2 3.7 7.3e-08 32.6 0.2 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK44543.1 - 2.1e-16 59.0 2.2 9.9e-07 28.3 0.2 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK44543.1 - 5e-14 51.6 6.1 0.27 11.7 0.0 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 PIK44543.1 - 5e-14 51.3 1.9 0.00042 20.3 0.1 5.2 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK44543.1 - 7.6e-14 51.2 0.1 0.00051 20.6 0.1 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK44543.1 - 4.3e-11 42.3 9.3 1e-05 25.1 0.0 4.9 3 2 2 5 5 5 2 TPR repeat TPR_19 PF14559.6 PIK44543.1 - 1.5e-10 41.5 0.9 0.1 13.1 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK44543.1 - 1.5e-10 40.3 2.1 9.7e-05 22.1 0.0 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK44543.1 - 4.1e-10 39.6 2.1 0.13 12.9 0.0 5.0 6 1 0 6 6 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK44543.1 - 6.3e-08 33.1 0.0 6.7e-06 26.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK44543.1 - 6.7e-08 32.6 0.1 0.0012 19.0 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK44543.1 - 1.5e-07 31.0 3.2 0.48 10.4 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK44543.1 - 9.9e-07 28.7 0.4 0.24 11.5 0.1 3.7 4 0 0 4 4 3 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 PIK44543.1 - 1.4e-05 25.2 4.9 0.015 15.5 0.2 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 PIK44543.1 - 5.2e-05 22.6 0.1 0.01 15.1 0.0 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 PIK44543.1 - 0.0013 18.4 0.5 0.0042 16.8 0.1 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 Clathrin PF00637.20 PIK44543.1 - 0.0019 18.1 1.1 0.003 17.4 1.1 1.3 1 0 0 1 1 1 1 Region in Clathrin and VPS SNAP PF14938.6 PIK44543.1 - 0.0032 17.0 0.4 0.0083 15.6 0.4 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 PIK44543.1 - 0.0038 17.8 0.8 9.1 7.1 0.0 3.9 4 0 0 4 4 4 0 Sel1 repeat MIT PF04212.18 PIK44543.1 - 0.0055 16.8 4.2 0.16 12.1 0.3 3.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TAF1_subA PF14929.6 PIK44543.1 - 0.018 14.5 0.2 0.25 10.7 0.2 1.9 1 1 1 2 2 2 0 TAF RNA Polymerase I subunit A USP8_dimer PF08969.11 PIK44543.1 - 0.026 14.7 0.1 0.055 13.7 0.1 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain LAS2 PF15792.5 PIK44543.1 - 0.13 12.8 0.1 0.23 12.0 0.1 1.4 1 0 0 1 1 1 0 Lung adenoma susceptibility protein 2 Aldo_ket_red PF00248.21 PIK44545.1 - 1.4e-49 168.9 0.0 2e-49 168.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PQ-loop PF04193.14 PIK44546.1 - 8.8e-16 57.4 0.6 8.8e-16 57.4 0.6 2.2 2 0 0 2 2 2 1 PQ loop repeat ER_lumen_recept PF00810.18 PIK44546.1 - 0.046 14.5 5.5 0.078 13.8 5.5 1.4 1 1 0 1 1 1 0 ER lumen protein retaining receptor SNARE_assoc PF09335.11 PIK44547.1 - 6.9e-15 55.6 7.1 6.9e-15 55.6 7.1 1.8 2 0 0 2 2 2 1 SNARE associated Golgi protein UPF0016 PF01169.19 PIK44547.1 - 0.017 15.5 0.7 5 7.5 0.2 2.7 2 1 0 2 2 2 0 Uncharacterized protein family UPF0016 Antimicrobial_4 PF08024.11 PIK44547.1 - 0.055 13.5 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Ant antimicrobial peptide Inhibitor_I9 PF05922.16 PIK44548.1 - 8.5e-08 32.8 0.2 6.3e-07 30.0 0.2 1.9 1 1 0 1 1 1 1 Peptidase inhibitor I9 Vps35 PF03635.17 PIK44549.1 - 1.3e-126 424.0 9.2 1.2e-93 315.0 2.2 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 35 Vps35 PF03635.17 PIK44550.1 - 1.3e-82 278.5 6.3 3.2e-64 217.7 2.3 2.7 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 35 Cas9_PI PF16595.5 PIK44550.1 - 0.086 12.7 2.7 1.8 8.4 0.1 2.9 3 0 0 3 3 3 0 PAM-interacting domain of CRISPR-associated endonuclease Cas9 Urb2 PF10441.9 PIK44550.1 - 0.9 9.4 3.1 3.1 7.7 0.2 3.1 2 1 1 3 3 3 0 Urb2/Npa2 family TIM21 PF08294.11 PIK44551.1 - 1.2e-36 125.8 0.4 2.4e-36 124.8 0.4 1.5 1 1 0 1 1 1 1 TIM21 Coa1 PF08695.10 PIK44551.1 - 0.00013 21.7 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Katanin_con80 PF13925.6 PIK44552.1 - 5.8e-48 162.9 1.3 6.5e-48 162.8 1.3 1.0 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.32 PIK44553.1 - 5.2e-52 172.7 10.3 8.7e-13 48.5 0.4 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44553.1 - 3.3e-20 72.2 0.0 7.1e-05 23.0 0.1 5.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK44553.1 - 2.4e-07 30.8 0.0 0.00077 19.4 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK44553.1 - 0.00085 18.1 0.1 0.41 9.2 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 PIK44553.1 - 0.0025 16.8 2.6 0.24 10.3 0.1 3.6 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 PIK44553.1 - 0.14 10.6 0.0 0.44 9.0 0.0 1.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain RINT1_TIP1 PF04437.13 PIK44554.1 - 0.0089 15.0 0.0 0.043 12.7 0.0 1.9 2 0 0 2 2 2 1 RINT-1 / TIP-1 family B56 PF01603.20 PIK44554.1 - 0.026 13.5 2.2 0.037 13.0 0.1 2.3 4 0 0 4 4 4 0 Protein phosphatase 2A regulatory B subunit (B56 family) MIF4G PF02854.19 PIK44554.1 - 0.064 12.9 3.0 0.41 10.2 0.3 2.9 3 0 0 3 3 3 0 MIF4G domain Ras PF00071.22 PIK44555.1 - 6.8e-59 198.1 0.1 8.6e-59 197.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK44555.1 - 5.9e-30 104.0 0.1 1.6e-29 102.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK44555.1 - 2.9e-11 43.2 0.0 3.5e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK44555.1 - 0.0025 17.4 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK44555.1 - 0.0037 16.6 0.0 0.0054 16.1 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK44555.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase SNF2_N PF00176.23 PIK44556.1 - 1.4e-66 224.6 0.1 2.9e-66 223.6 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 PIK44556.1 - 1.1e-19 70.0 3.4 1.1e-11 44.4 0.3 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 PIK44556.1 - 7.3e-18 64.9 0.1 3.4e-17 62.8 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK44556.1 - 1e-08 35.4 0.8 7e-08 32.7 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit BRK PF07533.16 PIK44557.1 - 5.8e-07 29.0 0.0 1.2e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 BRK domain DHHC PF01529.20 PIK44558.1 - 5.6e-35 120.4 16.5 5.6e-35 120.4 16.5 2.1 2 1 0 2 2 2 1 DHHC palmitoyltransferase CaMBD PF02888.16 PIK44559.1 - 0.031 14.5 0.1 0.054 13.7 0.1 1.3 1 0 0 1 1 1 0 Calmodulin binding domain TetR_C_36 PF18598.1 PIK44559.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FH2 PF02181.23 PIK44561.1 - 1.5e-64 218.5 0.4 1.5e-64 218.5 0.4 2.1 3 0 0 3 3 3 1 Formin Homology 2 Domain PH PF00169.29 PIK44561.1 - 1e-14 54.9 8.0 3.3e-07 30.8 0.7 3.3 3 0 0 3 3 3 2 PH domain PH_3 PF14593.6 PIK44561.1 - 1.3e-05 25.2 3.2 0.11 12.6 0.1 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 PIK44561.1 - 2.2e-05 24.8 7.3 0.0053 17.2 0.4 3.3 2 1 1 3 3 3 2 Pleckstrin homology domain Mito_fiss_reg PF05308.11 PIK44561.1 - 0.094 12.8 1.5 0.23 11.5 1.5 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-C3HC4_3 PF13920.6 PIK44562.1 - 3.8e-05 23.5 7.3 7.3e-05 22.6 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TBCC_N PF16752.5 PIK44562.1 - 7.1e-05 23.2 1.5 9.7e-05 22.8 1.5 1.2 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain zf-RING_5 PF14634.6 PIK44562.1 - 0.00034 20.5 2.0 0.00034 20.5 2.0 2.4 1 1 1 2 2 2 1 zinc-RING finger domain Mitofilin PF09731.9 PIK44562.1 - 0.00041 19.3 1.8 0.00046 19.2 1.8 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein zf-C3HC4_2 PF13923.6 PIK44562.1 - 0.0005 19.8 8.8 0.0011 18.8 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK44562.1 - 0.00073 19.3 6.6 0.0018 18.1 6.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Laminin_II PF06009.12 PIK44562.1 - 0.0017 18.4 4.0 0.0021 18.1 4.0 1.0 1 0 0 1 1 1 1 Laminin Domain II Plant_NMP1 PF06694.11 PIK44562.1 - 0.0068 15.6 0.5 0.0083 15.3 0.5 1.0 1 0 0 1 1 1 1 Plant nuclear matrix protein 1 (NMP1) Spc7 PF08317.11 PIK44562.1 - 0.012 14.5 9.3 0.015 14.2 9.3 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-RING_UBOX PF13445.6 PIK44562.1 - 0.015 15.3 7.9 0.031 14.3 7.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger OmpH PF03938.14 PIK44562.1 - 0.034 14.5 4.6 0.043 14.1 4.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MnmE_helical PF12631.7 PIK44562.1 - 0.044 13.9 3.0 0.052 13.7 3.0 1.1 1 0 0 1 1 1 0 MnmE helical domain YkyA PF10368.9 PIK44562.1 - 0.051 13.2 10.1 0.064 12.9 10.1 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Prok-RING_4 PF14447.6 PIK44562.1 - 0.052 13.4 7.6 0.15 12.0 7.7 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 PIK44562.1 - 0.055 13.3 2.5 0.099 12.5 2.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FYTT PF07078.11 PIK44562.1 - 0.078 12.3 0.6 0.075 12.3 0.6 1.1 1 0 0 1 1 1 0 Forty-two-three protein DUF1474 PF07342.11 PIK44562.1 - 0.079 13.5 1.5 1.1 9.8 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1474) DUF724 PF05266.14 PIK44562.1 - 0.087 12.6 6.8 0.11 12.3 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Helo_like_N PF17111.5 PIK44562.1 - 0.093 12.1 6.8 0.11 11.8 6.0 1.5 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins ACCA PF03255.14 PIK44562.1 - 0.27 11.1 5.2 0.32 10.9 5.2 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ran-binding PF05508.11 PIK44562.1 - 0.28 10.1 3.3 0.37 9.7 3.3 1.1 1 0 0 1 1 1 0 RanGTP-binding protein Remorin_C PF03763.13 PIK44562.1 - 0.32 10.9 9.8 0.45 10.4 9.8 1.2 1 0 0 1 1 1 0 Remorin, C-terminal region FemAB PF02388.16 PIK44562.1 - 0.33 9.8 6.5 0.39 9.5 6.5 1.0 1 0 0 1 1 1 0 FemAB family DUF1664 PF07889.12 PIK44562.1 - 0.36 10.9 4.5 0.41 10.7 3.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Cnn_1N PF07989.11 PIK44562.1 - 0.39 10.9 10.5 0.34 11.1 9.3 1.6 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 TMPIT PF07851.13 PIK44562.1 - 0.45 9.7 5.7 0.5 9.6 5.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein End3 PF12761.7 PIK44562.1 - 0.48 10.6 8.2 0.6 10.3 8.2 1.1 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF4407 PF14362.6 PIK44562.1 - 0.54 9.6 3.2 0.59 9.4 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_2 PF13639.6 PIK44562.1 - 0.58 10.5 14.1 0.46 10.9 11.5 2.2 2 1 1 3 3 2 0 Ring finger domain DUF5082 PF16888.5 PIK44562.1 - 0.74 10.1 9.2 5.9 7.2 9.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Syntaxin-6_N PF09177.11 PIK44562.1 - 0.74 10.4 7.1 0.63 10.6 4.4 1.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Med9 PF07544.13 PIK44562.1 - 0.79 9.9 8.3 0.9 9.7 7.0 1.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 zf-rbx1 PF12678.7 PIK44562.1 - 1.2 9.4 9.8 0.64 10.3 7.1 2.0 2 1 0 2 2 2 0 RING-H2 zinc finger domain SlyX PF04102.12 PIK44562.1 - 1.4 9.5 5.8 2.3 8.9 5.6 1.5 1 1 0 1 1 1 0 SlyX Pinin_SDK_memA PF04696.13 PIK44562.1 - 1.5 8.9 12.6 2.1 8.4 12.6 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region UPF0242 PF06785.11 PIK44562.1 - 1.8 8.7 9.4 2.3 8.3 9.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus KIP1 PF07765.12 PIK44562.1 - 2.9 8.1 7.0 4.1 7.6 6.5 1.6 1 1 1 2 2 2 0 KIP1-like protein zf-C3HC4_4 PF15227.6 PIK44562.1 - 3.9 7.7 11.4 25 5.1 11.5 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DivIC PF04977.15 PIK44562.1 - 4.6 7.1 11.4 8.2 6.3 4.2 2.2 1 1 1 2 2 2 0 Septum formation initiator FmiP_Thoc5 PF09766.9 PIK44563.1 - 8.3e-121 403.7 7.3 8.3e-121 403.7 7.3 1.8 2 0 0 2 2 2 1 Fms-interacting protein/Thoc5 BLOC1_2 PF10046.9 PIK44563.1 - 0.17 12.2 14.1 0.062 13.6 1.8 3.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RWD PF05773.22 PIK44563.1 - 0.28 11.5 2.6 0.52 10.6 0.1 2.7 3 0 0 3 3 3 0 RWD domain Csm2_III-A PF03750.13 PIK44563.1 - 3.3 8.6 7.5 2.9 8.7 0.6 2.8 1 1 1 2 2 2 0 Csm2 Type III-A Capsule_synth PF05159.14 PIK44564.1 - 0.0043 16.5 0.1 0.005 16.3 0.1 1.1 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein RFXA_RFXANK_bdg PF15289.6 PIK44564.1 - 4.7 7.6 8.9 0.16 12.3 2.9 1.6 2 0 0 2 2 2 0 Regulatory factor X-associated C-terminal binding domain MMR_HSR1_Xtn PF16897.5 PIK44565.1 - 8e-44 148.0 1.0 2.1e-43 146.7 1.0 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 PIK44565.1 - 3.5e-23 81.4 0.0 6e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 PIK44565.1 - 1.7e-19 70.0 0.0 4e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK44565.1 - 1.7e-10 40.6 0.0 1.5e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK44565.1 - 0.0025 17.9 0.1 3.1 7.8 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 PIK44565.1 - 0.007 15.4 0.2 0.02 13.9 0.1 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 PIK44565.1 - 0.013 15.1 0.0 5.4 6.5 0.0 3.5 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 PIK44565.1 - 0.14 12.7 0.1 0.75 10.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Pkinase PF00069.25 PIK44566.1 - 1.5e-40 139.2 0.0 1.9e-40 138.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44566.1 - 4.8e-21 75.2 0.0 5.9e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK44566.1 - 8e-07 28.6 0.1 1e-06 28.3 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK44566.1 - 4.5e-05 22.9 0.0 5.1e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 PIK44566.1 - 0.00041 20.0 0.0 0.0005 19.7 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 PIK44566.1 - 0.00055 18.8 0.0 0.00065 18.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK44566.1 - 0.0013 17.7 0.3 0.0015 17.6 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK44566.1 - 0.0077 16.2 0.0 0.0097 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.9 PIK44566.1 - 0.015 14.1 0.1 0.02 13.8 0.1 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Pox_ser-thr_kin PF05445.11 PIK44566.1 - 0.027 13.4 0.1 0.074 12.0 0.1 1.6 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 PIK44566.1 - 0.085 12.5 0.0 0.095 12.3 0.0 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase PF00069.25 PIK44567.1 - 4.1e-08 32.9 0.0 5.8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-B_box PF00643.24 PIK44568.1 - 8.7e-07 29.0 30.8 0.00028 20.9 5.6 3.4 3 0 0 3 3 3 2 B-box zinc finger FYVE_2 PF02318.16 PIK44568.1 - 0.034 14.4 3.8 0.034 14.4 3.8 2.9 2 1 1 3 3 3 0 FYVE-type zinc finger Peptidase_A17 PF05380.13 PIK44569.1 - 8.6e-56 188.4 0.0 1.5e-55 187.6 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK44569.1 - 1.8e-11 44.2 0.0 8.4e-11 42.0 0.0 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1759) rve PF00665.26 PIK44569.1 - 2.4e-07 31.0 0.0 6.6e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 PIK44569.1 - 0.00025 21.6 0.1 0.00059 20.4 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK44569.1 - 0.034 14.7 0.1 0.078 13.5 0.1 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF1758 PF05585.12 PIK44569.1 - 0.034 13.9 0.0 0.098 12.4 0.0 1.8 1 0 0 1 1 1 0 Putative peptidase (DUF1758) RVT_1 PF00078.27 PIK44569.1 - 0.034 13.7 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) FHA PF00498.26 PIK44570.1 - 1.2e-13 51.2 0.0 3.1e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-CRD PF17979.1 PIK44570.1 - 1.1e-11 45.0 11.7 1.1e-11 45.0 11.7 4.1 3 1 0 4 4 4 1 Cysteine rich domain with multizinc binding regions zf-C3HC4_2 PF13923.6 PIK44570.1 - 5.1e-09 35.8 15.1 5.1e-09 35.8 15.1 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK44570.1 - 7.5e-08 32.6 14.9 7.5e-08 32.6 14.9 3.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.25 PIK44570.1 - 3.3e-06 26.9 13.7 3.3e-06 26.9 13.7 3.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK44570.1 - 5.1e-06 26.2 15.8 5.1e-06 26.2 15.8 4.1 4 1 1 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK44570.1 - 5.9e-05 23.0 10.0 5.9e-05 23.0 10.0 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-CCHH PF10283.9 PIK44570.1 - 0.00013 21.9 2.7 0.00013 21.9 2.7 2.3 2 0 0 2 2 1 1 PBZ domain zf-RING_6 PF14835.6 PIK44570.1 - 0.00019 21.2 7.4 0.00019 21.2 7.4 2.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 PIK44570.1 - 0.00069 19.9 10.6 0.00069 19.9 10.6 3.5 4 0 0 4 4 3 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 PIK44570.1 - 0.00078 19.4 13.3 0.00078 19.4 13.3 3.4 2 0 0 2 2 1 1 zinc-RING finger domain Yop-YscD_cpl PF16697.5 PIK44570.1 - 0.0019 18.5 0.0 0.0038 17.5 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Prok-RING_4 PF14447.6 PIK44570.1 - 0.0029 17.4 15.8 0.0029 17.4 15.8 4.1 3 1 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 PIK44570.1 - 0.017 15.2 12.0 0.017 15.2 12.0 3.1 3 1 0 3 3 2 0 zinc RING finger of MSL2 OrfA PF17495.2 PIK44570.1 - 0.067 13.4 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Vpr-like OrfA SNAPc19 PF15497.6 PIK44571.1 - 0.0048 17.3 6.5 0.0048 17.3 6.5 3.9 2 2 1 3 3 3 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 ATG16 PF08614.11 PIK44571.1 - 0.018 15.3 52.3 0.033 14.4 12.1 3.0 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) DUF1866 PF08952.11 PIK44571.1 - 0.12 12.2 3.4 0.13 12.1 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) DUF3349 PF11829.8 PIK44571.1 - 3.9 8.3 9.8 0.26 12.1 2.3 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF3349) HIP1_clath_bdg PF16515.5 PIK44572.1 - 0.015 15.9 10.7 0.015 15.9 10.7 4.9 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2673 PF10880.8 PIK44573.1 - 0.12 12.5 0.1 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) Nop14 PF04147.12 PIK44574.1 - 0.055 11.7 12.8 0.063 11.5 12.8 1.1 1 0 0 1 1 1 0 Nop14-like family GvpL_GvpF PF06386.11 PIK44574.1 - 0.21 11.5 2.9 0.26 11.2 2.9 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF NPR3 PF03666.13 PIK44574.1 - 2.2 7.0 4.4 3 6.5 4.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_transf_10 PF00852.19 PIK44575.1 - 6.2e-51 172.6 6.2 6.6e-51 172.5 5.1 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK44575.1 - 1.4e-08 35.2 2.0 1.5e-08 35.1 0.1 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal S_locus_glycop PF00954.20 PIK44575.1 - 0.0075 16.8 2.2 0.061 13.8 0.7 2.7 2 0 0 2 2 2 1 S-locus glycoprotein domain GTP_EFTU PF00009.27 PIK44576.1 - 7.6e-97 322.5 8.4 1.4e-54 184.6 1.2 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK44576.1 - 2.5e-11 43.7 0.5 0.00018 21.6 0.1 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 PIK44576.1 - 3e-08 34.0 0.0 7.7e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 PIK44576.1 - 0.00077 19.8 0.0 0.0017 18.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 ABC_tran PF00005.27 PIK44576.1 - 0.005 17.3 0.1 5 7.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 PIK44576.1 - 0.0051 16.5 1.3 3.4 7.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain PduV-EutP PF10662.9 PIK44576.1 - 0.014 15.2 0.6 15 5.3 0.0 3.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Cas9_b_hairpin PF17893.1 PIK44576.1 - 0.034 14.0 0.1 13 5.7 0.0 2.5 2 0 0 2 2 2 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain MobB PF03205.14 PIK44576.1 - 0.068 13.1 1.4 15 5.5 0.1 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF4611 PF15387.6 PIK44576.1 - 0.085 13.1 0.0 27 5.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Ependymin PF00811.18 PIK44576.1 - 0.092 13.0 0.1 15 5.8 0.0 2.5 2 0 0 2 2 2 0 Ependymin Parvo_NS1 PF01057.17 PIK44576.1 - 0.16 11.0 0.4 15 4.5 0.1 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 CbiA PF01656.23 PIK44576.1 - 5.4 7.1 5.0 49 4.0 0.1 2.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain RT_RNaseH_2 PF17919.1 PIK44577.1 - 4.3e-28 97.3 0.0 8.1e-28 96.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44577.1 - 1.3e-25 90.3 0.0 3.3e-25 88.9 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK44577.1 - 1.4e-15 57.5 0.0 2.4e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GTP_EFTU_D3 PF03143.17 PIK44578.1 - 2.6e-23 82.4 0.0 3.6e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Peptidase_M14 PF00246.24 PIK44580.1 - 1.2e-121 406.0 0.0 2.8e-78 263.6 0.0 5.1 4 1 0 4 4 4 4 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 PIK44580.1 - 2.3e-27 95.1 0.6 4.8e-14 52.4 0.0 3.7 4 0 0 4 4 4 2 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 PIK44580.1 - 1.6e-18 66.5 0.1 3e-07 30.3 0.0 3.5 3 0 0 3 3 3 3 CarboxypepD_reg-like domain PEGA PF08308.11 PIK44580.1 - 2.9e-07 30.3 0.0 0.07 13.0 0.0 3.5 3 0 0 3 3 3 3 PEGA domain AstE_AspA PF04952.14 PIK44580.1 - 8e-05 21.8 0.0 0.00018 20.7 0.0 1.5 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 PIK44580.1 - 0.056 12.8 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Transmemb_17 PF09799.9 PIK44581.1 - 4.8e-26 91.4 13.0 6.8e-26 90.9 13.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein TMEM251 PF15190.6 PIK44581.1 - 0.067 13.1 0.2 0.067 13.1 0.2 2.2 1 1 0 2 2 2 0 Transmembrane protein 251 RseC_MucC PF04246.12 PIK44581.1 - 2.4 8.1 11.7 1.2 9.1 1.0 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF5090 PF17009.5 PIK44581.1 - 6.3 6.7 10.0 16 5.4 3.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5090) DEAD_2 PF06733.15 PIK44582.1 - 2.2e-34 118.6 4.0 3.3e-34 118.0 0.1 2.6 2 1 1 3 3 3 1 DEAD_2 SNF2_N PF00176.23 PIK44582.1 - 0.0016 17.3 0.0 0.0025 16.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HBB PF06777.11 PIK44582.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Helical and beta-bridge domain Helicase_C_2 PF13307.6 PIK44583.1 - 1.5e-42 145.7 0.0 3.1e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain FtsK_SpoIIIE_N PF12538.8 PIK44583.1 - 0.11 12.7 3.8 0.23 11.6 3.8 1.5 1 0 0 1 1 1 0 DNA transporter Glu_cyclase_2 PF05096.12 PIK44584.1 - 0.0046 16.4 0.0 0.0076 15.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine cyclotransferase NHL PF01436.21 PIK44584.1 - 0.059 13.4 1.9 7.4 6.8 0.0 4.6 4 1 1 5 5 5 0 NHL repeat GAS PF13851.6 PIK44585.1 - 8.1e-09 35.1 97.4 0.0015 17.9 28.1 4.8 1 1 3 4 4 4 4 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK44585.1 - 1.3e-07 31.7 106.2 7.8e-05 22.6 33.1 3.3 1 1 2 3 3 3 3 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK44585.1 - 3e-06 27.8 110.7 0.00038 21.0 33.4 4.9 1 1 4 5 5 5 4 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 PIK44585.1 - 3.2e-06 27.7 101.4 0.0047 17.5 19.5 5.3 2 1 3 5 5 5 3 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4472 PF14739.6 PIK44585.1 - 0.011 16.5 83.6 0.25 12.1 13.8 6.2 1 1 5 6 6 6 0 Domain of unknown function (DUF4472) TACC_C PF05010.14 PIK44585.1 - 0.04 13.7 81.1 0.31 10.8 26.0 3.2 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 PIK44585.1 - 0.076 13.1 55.1 0.15 12.1 8.7 5.3 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) HBM PF16591.5 PIK44585.1 - 0.18 11.2 64.6 0.57 9.6 37.3 4.1 1 1 2 3 3 3 0 Helical bimodular sensor domain Fez1 PF06818.15 PIK44585.1 - 0.37 11.2 86.8 5 7.5 37.0 3.6 1 1 2 3 3 3 0 Fez1 HMMR_N PF15905.5 PIK44585.1 - 0.43 10.0 91.0 0.044 13.3 42.1 2.9 1 1 1 2 2 1 0 Hyaluronan mediated motility receptor N-terminal P_proprotein PF01483.20 PIK44585.1 - 0.63 10.1 6.2 3.3 7.8 1.5 2.8 2 0 0 2 2 2 0 Proprotein convertase P-domain PilA4 PF18682.1 PIK44585.1 - 0.75 10.2 27.1 22 5.5 0.3 8.2 2 1 5 8 8 8 0 Pilin A4 Peptidase_S21 PF00716.17 PIK44585.1 - 1.5 8.4 7.6 7.3 6.2 0.8 2.6 2 0 0 2 2 2 0 Assemblin (Peptidase family S21) Spc7 PF08317.11 PIK44585.1 - 1.8 7.4 91.4 0.7 8.7 25.5 4.2 1 1 4 5 5 5 0 Spc7 kinetochore protein KASH_CCD PF14662.6 PIK44585.1 - 1.9 8.2 97.5 0.66 9.8 14.7 5.3 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH T2SSN PF01203.19 PIK44585.1 - 9 6.4 24.8 6.9 6.8 3.0 4.6 1 1 1 4 4 4 0 Type II secretion system (T2SS), protein N TPD52 PF04201.15 PIK44585.1 - 9 5.9 74.5 1.2 8.7 8.4 7.1 1 1 6 7 7 7 0 Tumour protein D52 family ZU5 PF00791.20 PIK44586.1 - 1.1e-07 32.1 0.8 2.5e-07 31.0 0.1 1.9 2 0 0 2 2 2 1 ZU5 domain DED PF01335.21 PIK44587.1 - 0.003 17.8 1.3 0.0067 16.7 1.3 1.6 1 0 0 1 1 1 1 Death effector domain DUF4800 PF16057.5 PIK44589.1 - 0.0034 16.7 0.3 0.0055 16.0 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) DUF724 PF05266.14 PIK44589.1 - 0.049 13.5 4.8 0.094 12.5 4.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3450 PF11932.8 PIK44589.1 - 0.089 12.1 4.1 0.16 11.3 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1690 PF07956.11 PIK44589.1 - 0.17 12.3 10.7 0.42 11.0 6.8 2.3 1 1 0 2 2 2 0 Protein of Unknown function (DUF1690) TMPIT PF07851.13 PIK44589.1 - 0.23 10.7 2.0 0.34 10.1 2.0 1.4 1 0 0 1 1 1 0 TMPIT-like protein KxDL PF10241.9 PIK44589.1 - 0.4 11.0 9.5 0.24 11.7 6.0 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein Phage_int_SAM_6 PF18644.1 PIK44589.1 - 0.77 9.8 6.1 0.51 10.4 1.3 2.7 2 1 1 3 3 3 0 Phage integrase SAM-like domain XhlA PF10779.9 PIK44589.1 - 1.4 9.2 6.0 23 5.3 0.4 2.9 1 1 1 2 2 2 0 Haemolysin XhlA Fib_alpha PF08702.10 PIK44589.1 - 3.9 7.7 9.8 6.5 6.9 5.7 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Med4 PF10018.9 PIK44589.1 - 4.4 6.9 8.2 4.2 7.0 6.3 1.9 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 AAA_25 PF13481.6 PIK44590.1 - 0.0084 15.7 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain bZIP_1 PF00170.21 PIK44591.1 - 2.7e-05 24.2 11.5 4.5e-05 23.5 11.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK44591.1 - 0.00085 19.4 10.7 0.00085 19.4 10.7 1.5 2 0 0 2 2 2 1 Basic region leucine zipper Jnk-SapK_ap_N PF09744.9 PIK44591.1 - 0.012 15.9 4.7 0.013 15.7 4.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PCRF PF03462.18 PIK44591.1 - 0.024 14.5 0.4 0.031 14.2 0.4 1.1 1 0 0 1 1 1 0 PCRF domain Peptidase_A17 PF05380.13 PIK44593.1 - 6.5e-09 36.0 0.0 1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK44593.1 - 0.0024 18.0 0.0 0.0042 17.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DNA_pol_viral_C PF00336.18 PIK44593.1 - 0.017 14.6 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain ParD_antitoxin PF03693.14 PIK44594.1 - 9.5 6.7 7.8 5.3 7.5 0.5 4.0 3 0 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Comm PF15957.5 PIK44595.1 - 0.017 15.5 0.0 0.046 14.1 0.0 1.7 1 1 0 1 1 1 0 Commissureless DUF5527 PF17665.1 PIK44595.1 - 0.13 11.8 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DUF4191 PF13829.6 PIK44595.1 - 0.33 10.3 1.8 0.56 9.5 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SieB PF14163.6 PIK44595.1 - 0.41 10.1 1.4 0.58 9.6 1.4 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B Peptidase_M16 PF00675.20 PIK44596.1 - 3.9e-26 91.8 0.0 6.3e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 PIK44596.1 - 1e-20 74.6 0.0 5.2e-20 72.2 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Glyco_hydro_20 PF00728.22 PIK44597.1 - 6.8e-12 45.4 0.0 1.8e-11 44.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain DUF4838 PF16126.5 PIK44597.1 - 2.4e-05 23.9 0.1 3.7e-05 23.2 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4838) Ank_4 PF13637.6 PIK44598.1 - 6.3e-11 42.6 0.1 1.4e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK44598.1 - 8.4e-11 41.1 0.0 2e-06 27.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 PIK44598.1 - 1.1e-10 41.5 0.4 1.1e-05 25.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 PIK44598.1 - 1e-09 38.8 0.0 1.6e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK44598.1 - 4.1e-05 23.8 0.1 0.00026 21.2 0.1 2.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ribosomal_L1 PF00687.21 PIK44599.1 - 2.6e-44 151.4 0.6 2.6e-44 151.4 0.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Beta-lactamase PF00144.24 PIK44600.1 - 3.4e-51 174.5 0.0 5.2e-51 173.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase AAA_11 PF13086.6 PIK44601.1 - 1.6e-07 31.4 1.6 4.7e-07 29.9 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 PIK44601.1 - 6e-05 22.8 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK44601.1 - 0.00021 21.7 0.0 0.00055 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain TPR_1 PF00515.28 PIK44601.1 - 0.0025 17.5 0.3 0.64 9.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-CCCH_4 PF18044.1 PIK44601.1 - 0.0038 17.0 0.2 0.011 15.5 0.2 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C2H2_jaz PF12171.8 PIK44601.1 - 0.0073 16.6 4.2 0.018 15.3 4.2 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding UvrD-helicase PF00580.21 PIK44601.1 - 0.0074 15.8 0.4 0.057 12.9 0.0 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 PIK44601.1 - 0.0084 15.6 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein TPR_14 PF13428.6 PIK44601.1 - 0.0085 16.8 0.2 0.34 11.8 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat zf-CCCH PF00642.24 PIK44601.1 - 0.012 15.5 0.3 0.034 14.1 0.3 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ResIII PF04851.15 PIK44601.1 - 0.013 15.5 0.2 0.041 13.9 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 PIK44601.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK44601.1 - 0.016 15.5 0.0 0.067 13.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain TPR_19 PF14559.6 PIK44601.1 - 0.021 15.3 0.3 0.054 14.0 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_16 PF13191.6 PIK44601.1 - 0.027 14.9 0.0 0.57 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain zf-C2H2_2 PF12756.7 PIK44601.1 - 0.049 14.0 2.2 0.16 12.3 2.2 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) AAA_7 PF12775.7 PIK44601.1 - 0.089 12.3 0.1 0.37 10.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PIF1 PF05970.14 PIK44601.1 - 0.098 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase Helicase_RecD PF05127.14 PIK44601.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Helicase ANAPC3 PF12895.7 PIK44601.1 - 0.11 12.8 0.3 0.31 11.3 0.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Bac_DnaA PF00308.18 PIK44601.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein zf-met PF12874.7 PIK44601.1 - 0.28 11.7 7.8 0.7 10.4 7.8 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type TPR_2 PF07719.17 PIK44601.1 - 0.33 11.2 4.9 11 6.5 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4187 PF13821.6 PIK44601.1 - 1 9.2 6.2 0.55 10.1 3.4 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4187) AAA_12 PF13087.6 PIK44602.1 - 5.9e-27 94.6 0.0 7.8e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain PAM2 PF07145.15 PIK44602.1 - 4.9e-06 25.9 0.2 1.2e-05 24.6 0.2 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Ssu72 PF04722.13 PIK44602.1 - 0.04 13.5 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Ssu72-like protein UvrD_C_2 PF13538.6 PIK44602.1 - 0.085 12.7 0.1 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Josephin PF02099.17 PIK44604.1 - 6.3e-27 94.7 3.3 6.6e-25 88.1 3.3 2.0 1 1 0 1 1 1 1 Josephin Pkinase_Tyr PF07714.17 PIK44605.1 - 1.1e-29 103.5 0.0 1.6e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44605.1 - 1.5e-18 67.1 0.0 2.4e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK44605.1 - 1.2e-07 31.7 4.4 4.7e-06 26.6 0.1 3.0 3 1 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK44605.1 - 0.00052 20.6 2.2 1.4 9.6 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Kinase-like PF14531.6 PIK44605.1 - 0.018 14.4 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like ig PF00047.25 PIK44605.1 - 0.023 14.9 0.9 3.1 8.1 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain MFS_1 PF07690.16 PIK44606.1 - 5.6e-37 127.5 24.9 7.1e-37 127.1 24.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Helicase_C PF00271.31 PIK44607.1 - 2.1e-15 57.0 0.0 7.5e-15 55.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK44607.1 - 6.3e-12 45.6 0.0 1.1e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK44607.1 - 0.0044 17.0 0.0 0.0094 16.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 PIK44607.1 - 0.12 13.2 1.4 0.16 12.7 0.0 2.0 2 0 0 2 2 2 0 RecQ zinc-binding 7tm_1 PF00001.21 PIK44608.1 - 1.5e-37 129.3 18.2 1.9e-37 129.0 18.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK44608.1 - 1.1e-13 51.4 12.3 1.1e-13 51.4 12.3 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK44608.1 - 7.6e-05 22.2 11.0 0.00012 21.6 10.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK44608.1 - 0.00075 19.0 17.1 0.0019 17.6 17.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 PIK44608.1 - 0.0052 16.6 10.8 0.0052 16.6 10.8 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Shisa PF13908.6 PIK44608.1 - 0.6 10.3 3.9 1 9.6 3.2 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator RVT_1 PF00078.27 PIK44609.1 - 5.6e-05 22.8 0.0 0.00012 21.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UFD1 PF03152.14 PIK44610.1 - 7.2e-78 260.0 0.1 8.7e-78 259.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 PIK44610.1 - 0.045 13.5 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.18 PIK44610.1 - 0.058 13.6 0.0 2.4 8.4 0.0 2.4 1 1 0 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain GatD_N PF18195.1 PIK44610.1 - 0.14 11.5 0.0 2.7 7.4 0.0 2.5 3 0 0 3 3 3 0 GatD N-terminal domain TPMT PF05724.11 PIK44611.1 - 1.1e-36 126.6 0.0 1.2e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 PIK44611.1 - 0.0017 18.2 0.0 0.0024 17.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK44611.1 - 0.03 15.0 0.0 0.19 12.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK44611.1 - 0.098 13.3 0.0 0.28 11.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain CUB PF00431.20 PIK44612.1 - 4.2e-79 262.0 1.5 5.7e-26 91.0 0.1 3.3 3 0 0 3 3 3 3 CUB domain Peptidase_S8 PF00082.22 PIK44612.1 - 8.6e-27 94.2 18.5 4e-18 65.7 0.5 3.5 3 1 1 4 4 4 2 Subtilase family Inhibitor_I9 PF05922.16 PIK44612.1 - 1.2e-09 38.6 0.0 2.1e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 adh_short PF00106.25 PIK44613.1 - 9.3e-34 116.6 0.2 1.1e-33 116.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK44613.1 - 2.5e-25 89.4 0.1 3e-25 89.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK44613.1 - 3.2e-10 40.2 0.1 4.3e-10 39.8 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 PIK44613.1 - 0.00021 21.2 0.4 0.00036 20.5 0.4 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Arm_vescicular PF18770.1 PIK44613.1 - 0.0082 16.1 0.1 0.032 14.2 0.0 1.9 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor 3Beta_HSD PF01073.19 PIK44613.1 - 0.039 13.0 0.1 0.05 12.6 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family CAF1 PF04857.20 PIK44614.1 - 1.2e-74 251.4 0.3 1.6e-74 251.0 0.3 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.11 PIK44614.1 - 0.03 14.3 0.2 0.3 11.1 0.0 2.5 2 1 0 2 2 2 0 RNA binding domain An_peroxidase PF03098.15 PIK44615.1 - 3.5e-47 161.2 0.0 3.7e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 PIK44616.1 - 1.5e-59 202.0 0.0 1.7e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase zf-Mss51 PF13824.6 PIK44616.1 - 0.078 13.1 0.0 0.42 10.8 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 BCL_N PF04714.13 PIK44617.1 - 2.6e-27 94.6 5.9 2.6e-27 94.6 5.9 2.2 3 0 0 3 3 3 1 BCL7, N-terminal conserver region BUD22 PF09073.10 PIK44617.1 - 0.071 12.5 36.1 0.089 12.1 36.1 1.1 1 0 0 1 1 1 0 BUD22 DUF4770 PF15994.5 PIK44617.1 - 9.6 6.4 11.5 0.32 11.2 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) HEAT_2 PF13646.6 PIK44618.1 - 0.13 12.7 3.6 24 5.4 0.0 4.7 5 0 0 5 5 5 0 HEAT repeats HEAT_EZ PF13513.6 PIK44618.1 - 0.16 12.5 0.7 7.9 7.1 0.2 3.4 2 0 0 2 2 2 0 HEAT-like repeat HEAT PF02985.22 PIK44618.1 - 0.95 9.9 2.8 8.5 6.9 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat HEAT PF02985.22 PIK44619.1 - 1.8e-40 133.5 25.6 0.028 14.6 0.0 21.6 23 0 0 23 23 21 8 HEAT repeat HEAT_EZ PF13513.6 PIK44619.1 - 6.5e-35 119.1 20.2 0.00086 19.8 0.0 16.6 15 1 2 17 17 15 6 HEAT-like repeat HEAT_2 PF13646.6 PIK44619.1 - 1.2e-31 109.0 24.6 0.0011 19.3 0.0 13.0 7 5 9 16 16 15 8 HEAT repeats Cnd1 PF12717.7 PIK44619.1 - 8.3e-17 61.7 8.5 0.018 15.1 0.0 9.5 7 3 3 11 11 11 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK44619.1 - 1.2e-15 57.9 0.2 0.16 12.6 0.0 9.1 7 3 4 11 11 10 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 PIK44619.1 - 8.9e-12 44.3 6.6 0.0026 16.4 0.1 7.2 7 3 1 8 8 8 3 Adaptin N terminal region CLASP_N PF12348.8 PIK44619.1 - 1.4e-11 44.5 1.8 0.0022 17.6 0.0 6.2 6 1 1 7 7 7 2 CLASP N terminal MMS19_C PF12460.8 PIK44619.1 - 2e-07 30.5 17.6 0.0091 15.2 0.0 8.3 9 2 0 9 9 9 3 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 PIK44619.1 - 3e-05 23.3 6.9 3 6.9 0.4 6.4 6 1 0 6 6 6 1 Dopey, N-terminal ParcG PF10274.9 PIK44619.1 - 4.3e-05 23.7 4.5 1.2 9.2 0.0 6.6 6 1 1 7 7 7 1 Parkin co-regulated protein DUF3535 PF12054.8 PIK44619.1 - 0.0003 20.2 5.8 0.46 9.7 0.0 5.7 7 0 0 7 7 7 1 Domain of unknown function (DUF3535) DUF3385 PF11865.8 PIK44619.1 - 0.00043 20.2 9.0 1.6 8.7 0.0 6.8 7 2 0 8 8 7 1 Domain of unknown function (DUF3385) RTP1_C1 PF10363.9 PIK44619.1 - 0.00074 19.7 5.7 2.9 8.1 0.1 6.2 5 3 2 7 7 6 2 Required for nuclear transport of RNA pol II C-terminus 1 RICTOR_N PF14664.6 PIK44619.1 - 0.017 14.1 0.4 0.58 9.1 0.0 3.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term CAAP1 PF15335.6 PIK44619.1 - 0.021 15.3 0.0 8 7.1 0.0 2.8 2 0 0 2 2 2 0 Caspase activity and apoptosis inhibitor 1 Cnd3 PF12719.7 PIK44619.1 - 0.037 13.2 0.4 13 4.9 0.2 4.0 4 0 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain DUF4042 PF13251.6 PIK44619.1 - 0.041 13.6 0.3 16 5.2 0.0 4.9 4 1 0 4 4 3 0 Domain of unknown function (DUF4042) RIX1 PF08167.12 PIK44619.1 - 0.087 12.6 9.9 2.3 7.9 0.1 6.6 7 2 1 8 8 7 0 rRNA processing/ribosome biogenesis Ecm29 PF13001.7 PIK44619.1 - 0.19 10.4 7.5 0.69 8.5 0.0 5.4 8 1 1 9 9 9 0 Proteasome stabiliser DUF1678 PF07913.11 PIK44619.1 - 0.19 11.5 0.5 2.3 8.0 0.0 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF1678) Arm PF00514.23 PIK44619.1 - 0.42 10.7 24.6 0.87 9.7 0.5 9.6 11 1 1 12 12 10 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 PIK44619.1 - 3.9 6.5 20.6 22 4.0 0.1 7.3 6 2 2 8 8 8 0 Interferon-related developmental regulator (IFRD) PIP49_C PF12260.8 PIK44621.1 - 1.7e-08 34.3 0.4 3.7e-08 33.2 0.4 1.5 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Pkinase_Tyr PF07714.17 PIK44621.1 - 3.4e-06 26.6 1.2 8.5e-06 25.2 1.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44621.1 - 0.00026 20.4 0.1 0.00045 19.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pyr_redox_2 PF07992.14 PIK44622.1 - 3.2e-46 157.9 0.0 3.7e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK44622.1 - 8.4e-07 29.5 0.3 2.5e-05 24.8 0.2 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mito_fiss_Elm1 PF06258.11 PIK44622.1 - 0.038 13.1 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial fission ELM1 NAD_binding_9 PF13454.6 PIK44622.1 - 0.073 13.0 0.2 9.6 6.2 0.0 2.6 1 1 1 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 PIK44622.1 - 0.18 11.0 0.0 0.41 9.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Na_Ca_ex PF01699.24 PIK44623.1 - 2.7e-50 170.3 43.2 7.4e-28 97.4 13.1 3.1 3 0 0 3 3 3 2 Sodium/calcium exchanger protein rve PF00665.26 PIK44625.1 - 2.2e-19 69.8 0.0 4.6e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44625.1 - 4.4e-17 61.9 2.4 1.1e-16 60.7 2.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK44625.1 - 5.8e-05 23.2 0.4 5.8e-05 23.2 0.4 1.9 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK44625.1 - 0.0014 18.4 0.4 0.051 13.3 0.0 2.7 2 1 1 3 3 3 1 Integrase core domain DCX PF03607.17 PIK44626.1 - 0.0012 18.9 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Doublecortin Ig_3 PF13927.6 PIK44628.1 - 5.6e-13 49.3 2.9 5.4e-05 23.7 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK44628.1 - 1.5e-11 44.5 4.0 0.002 18.4 0.1 3.9 3 2 1 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK44628.1 - 1.4e-08 34.8 2.2 0.0024 18.0 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK44628.1 - 9.3e-06 25.6 1.1 0.18 11.9 0.1 3.0 2 1 1 3 3 3 2 Immunoglobulin I-set domain Izumo-Ig PF16706.5 PIK44628.1 - 0.0024 17.9 0.1 0.02 15.0 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain V-set PF07686.17 PIK44628.1 - 0.0035 17.5 2.6 0.42 10.8 0.0 3.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK44628.1 - 0.0045 17.4 4.5 0.63 10.5 0.5 3.5 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 PIK44628.1 - 0.0045 17.0 0.1 0.016 15.2 0.0 2.0 2 0 0 2 2 2 1 C17orf99 Ig domain RT_RNaseH_2 PF17919.1 PIK44629.1 - 1.8e-35 120.9 0.1 4e-35 119.9 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44629.1 - 3.9e-28 97.8 0.0 8.2e-28 96.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MucB_RseB_C PF17188.4 PIK44630.1 - 0.046 14.0 0.0 0.069 13.4 0.0 1.4 1 0 0 1 1 1 0 MucB/RseB C-terminal domain DSPc PF00782.20 PIK44631.1 - 2.9e-17 62.7 0.0 4.2e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK44631.1 - 8.9e-06 25.9 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPn PF14671.6 PIK44631.1 - 0.00034 21.1 0.1 0.0045 17.4 0.0 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.27 PIK44631.1 - 0.0025 17.4 0.2 0.018 14.6 0.1 1.9 1 1 0 2 2 2 1 Protein-tyrosine phosphatase Sec34 PF04136.15 PIK44631.1 - 0.022 14.6 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Sec34-like family V-set PF07686.17 PIK44632.1 - 2.7e-05 24.3 0.0 6.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF2615 PF11027.8 PIK44632.1 - 0.013 15.7 0.1 0.027 14.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) FtsX PF02687.21 PIK44632.1 - 0.031 14.7 0.4 0.073 13.5 0.4 1.5 1 0 0 1 1 1 0 FtsX-like permease family Mod_r PF07200.13 PIK44633.1 - 0.0094 16.1 1.5 0.017 15.2 1.5 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein KfrA_N PF11740.8 PIK44633.1 - 0.17 12.5 1.8 0.33 11.7 1.3 1.7 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term Pkinase_Tyr PF07714.17 PIK44634.1 - 1.9e-27 96.2 0.1 4.3e-27 95.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK44634.1 - 6.3e-27 94.0 0.5 3e-07 31.0 0.0 6.4 6 0 0 6 6 6 4 Immunoglobulin domain Pkinase PF00069.25 PIK44634.1 - 2.1e-22 79.7 0.0 4.6e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK44634.1 - 8.9e-18 64.4 0.3 7.8e-07 29.3 0.0 5.8 5 1 1 6 6 6 2 Immunoglobulin domain I-set PF07679.16 PIK44634.1 - 3.2e-17 62.3 0.0 2.9e-07 30.5 0.0 4.9 5 0 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.25 PIK44634.1 - 5.9e-12 45.6 0.0 0.0035 17.5 0.0 5.8 6 1 0 6 6 6 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK44634.1 - 1.2e-08 34.9 0.0 0.13 12.3 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK44634.1 - 7.1e-08 32.6 0.1 1.2 9.3 0.0 5.2 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_C17orf99 PF17736.1 PIK44634.1 - 0.01 15.8 0.0 0.052 13.6 0.0 2.2 2 0 0 2 2 2 0 C17orf99 Ig domain DUF1943 PF09172.11 PIK44635.1 - 2.7e-09 36.7 0.0 3.8e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) VWD PF00094.25 PIK44636.1 - 5e-13 49.6 1.6 1.3e-06 28.8 0.4 2.4 2 0 0 2 2 2 2 von Willebrand factor type D domain WDCP PF15390.6 PIK44637.1 - 0.15 10.4 3.5 0.17 10.2 3.5 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF5320 PF17253.2 PIK44637.1 - 0.28 12.3 0.4 0.28 12.3 0.4 2.2 2 1 0 3 3 3 0 Family of unknown function (DUF5320) Y_phosphatase PF00102.27 PIK44639.1 - 9.6e-21 74.4 1.3 2e-20 73.4 1.3 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK44639.1 - 1.8e-13 50.6 2.4 2.4e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Syndecan PF01034.20 PIK44639.1 - 0.045 13.7 0.9 0.1 12.5 0.9 1.6 1 0 0 1 1 1 0 Syndecan domain TMEM154 PF15102.6 PIK44639.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 TMEM154 protein family FGGY_C PF02782.16 PIK44640.1 - 1.2e-34 119.8 0.3 5.3e-34 117.7 0.3 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 PIK44640.1 - 1.1e-19 71.0 2.9 1e-14 54.7 0.0 4.0 3 1 0 3 3 3 2 FGGY family of carbohydrate kinases, N-terminal domain ALS2CR8 PF15299.6 PIK44640.1 - 2.5e-14 53.7 0.2 4.1e-14 53.0 0.2 1.3 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 FAR1 PF03101.15 PIK44640.1 - 0.014 16.0 0.3 0.041 14.6 0.3 1.7 1 0 0 1 1 1 0 FAR1 DNA-binding domain DUF92 PF01940.16 PIK44642.1 - 8.8e-07 28.6 0.0 6.5e-06 25.7 0.0 2.0 1 1 0 1 1 1 1 Integral membrane protein DUF92 DUF92 PF01940.16 PIK44643.1 - 1.7e-28 99.6 1.2 2e-28 99.4 1.2 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 CD99L2 PF12301.8 PIK44643.1 - 0.028 14.7 0.3 0.028 14.7 0.3 1.5 2 0 0 2 2 2 0 CD99 antigen like protein 2 DSPc PF00782.20 PIK44645.1 - 3e-42 143.6 0.0 7.1e-42 142.4 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK44645.1 - 1.5e-12 48.0 0.0 8.6e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 PIK44645.1 - 0.00012 21.7 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK44645.1 - 0.037 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1387 PF07139.11 PIK44645.1 - 1.6 8.4 11.3 2.7 7.7 11.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF1410 PF07198.11 PIK44646.1 - 0.72 10.4 7.8 0.7 10.4 5.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) DUF2207 PF09972.9 PIK44646.1 - 5 5.8 8.9 1.5 7.5 5.3 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) ATG16 PF08614.11 PIK44646.1 - 5.3 7.2 30.0 0.059 13.6 18.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PX PF00787.24 PIK44648.1 - 5.3e-14 52.2 1.5 1.2e-13 51.1 1.5 1.6 1 0 0 1 1 1 1 PX domain PH PF00169.29 PIK44648.1 - 2.7e-07 31.0 0.9 6.1e-07 29.9 0.2 2.0 2 1 0 2 2 2 1 PH domain Kinesin PF00225.23 PIK44649.1 - 1.7e-109 365.8 0.1 2.7e-109 365.1 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK44649.1 - 1.1e-22 80.6 0.0 2.3e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 PIK44649.1 - 9.2e-06 25.9 6.4 0.00012 22.3 1.0 3.1 2 1 1 3 3 3 2 Kinesin-associated FHA PF00498.26 PIK44649.1 - 0.00049 20.4 0.0 0.008 16.5 0.0 2.6 2 0 0 2 2 2 1 FHA domain GAS PF13851.6 PIK44649.1 - 0.0062 15.9 0.7 0.012 15.0 0.7 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Chorein_N PF12624.7 PIK44650.1 - 1.2e-17 64.1 0.0 6e-17 61.8 0.0 2.1 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 PIK44650.1 - 0.00034 20.4 0.4 0.0022 17.7 0.4 2.3 1 1 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13 PF16908.5 PIK44650.1 - 0.016 15.0 0.0 0.061 13.1 0.0 2.0 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal Rap1-DNA-bind PF09197.10 PIK44650.1 - 0.21 12.2 3.8 11 6.6 0.7 3.3 2 1 0 2 2 2 0 Rap1, DNA-binding Lipocalin_7 PF14651.6 PIK44651.1 - 3.8e-07 30.1 0.4 4.2e-07 29.9 0.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 PIK44653.1 - 8.6e-08 32.5 0.1 1e-07 32.2 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 PIK44654.1 - 1.1e-10 41.8 0.0 1.2e-10 41.7 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK44654.1 - 0.0069 16.3 0.0 0.008 16.1 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Auxin_resp PF06507.13 PIK44654.1 - 0.034 14.4 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 Auxin response factor Myosin_N PF02736.19 PIK44654.1 - 0.18 11.6 0.5 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Lipocalin PF00061.23 PIK44655.1 - 2e-10 41.1 0.0 2.3e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK44655.1 - 0.00061 19.7 0.0 0.00078 19.4 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 PIK44656.1 - 2.2e-06 27.9 0.0 2.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK44656.1 - 0.0028 17.6 0.0 0.0042 17.0 0.0 1.3 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family TF_Zn_Ribbon PF08271.12 PIK44657.1 - 1.1e-13 50.5 3.1 1.6e-13 50.0 3.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding TFIIB PF00382.19 PIK44657.1 - 6.1e-11 42.2 0.2 8.4e-11 41.8 0.2 1.2 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Cyclin_N PF00134.23 PIK44657.1 - 7.4e-07 29.0 0.1 1e-06 28.5 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain RB_B PF01857.20 PIK44657.1 - 0.00034 20.6 0.3 0.00047 20.2 0.3 1.1 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Prim_Zn_Ribbon PF08273.12 PIK44657.1 - 0.0016 18.7 4.0 0.0044 17.3 4.0 1.8 1 1 0 1 1 1 1 Zinc-binding domain of primase-helicase zf-ribbon_3 PF13248.6 PIK44657.1 - 0.0025 17.2 3.2 0.32 10.5 0.5 2.4 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.6 PIK44657.1 - 0.0079 15.9 1.3 2.2 8.1 0.4 2.5 2 0 0 2 2 2 2 zinc-ribbon domain Auto_anti-p27 PF06677.12 PIK44657.1 - 0.023 14.8 1.3 0.051 13.7 1.3 1.6 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 PIK44657.1 - 0.026 14.5 0.3 0.062 13.3 0.3 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf_Rg PF17915.1 PIK44657.1 - 0.095 12.1 1.1 0.2 11.1 1.1 1.5 1 0 0 1 1 1 0 Reverse gyrase zinc finger Zn-ribbon_8 PF09723.10 PIK44657.1 - 0.57 10.3 3.1 3.5 7.8 0.5 2.3 1 1 2 3 3 3 0 Zinc ribbon domain DUF1610 PF07754.11 PIK44657.1 - 1.1 9.2 9.0 7.6 6.6 2.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) BTB PF00651.31 PIK44658.1 - 4.4e-25 88.1 0.4 1.5e-24 86.4 0.1 2.1 3 0 0 3 3 3 1 BTB/POZ domain PHR PF08005.12 PIK44658.1 - 4.7e-15 56.6 0.0 1.8e-14 54.7 0.1 1.9 2 0 0 2 2 2 1 PHR domain BACK PF07707.15 PIK44658.1 - 4.6e-09 36.3 5.0 3.6e-08 33.4 2.9 2.8 1 1 1 2 2 2 1 BTB And C-terminal Kelch PriCT_1 PF08708.11 PIK44658.1 - 0.22 11.3 2.6 15 5.4 0.1 3.0 3 0 0 3 3 3 0 Primase C terminal 1 (PriCT-1) BRF1 PF07741.13 PIK44659.1 - 3.4e-24 85.1 16.8 3.4e-24 85.1 16.8 1.7 2 0 0 2 2 2 1 Brf1-like TBP-binding domain CAS_C PF12026.8 PIK44659.1 - 0.25 11.4 5.4 0.36 10.9 5.4 1.2 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Presenilin PF01080.17 PIK44659.1 - 1.9 7.2 3.4 2.1 7.0 3.4 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 PIK44660.1 - 0.27 9.6 7.6 0.24 9.7 6.8 1.2 1 1 0 1 1 1 0 Menin NESP55 PF06390.12 PIK44660.1 - 5.1 6.6 18.7 0.8 9.3 14.4 1.8 1 1 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Adenylsucc_synt PF00709.21 PIK44661.1 - 2.4e-129 431.9 0.3 2.7e-129 431.8 0.3 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF3584 PF12128.8 PIK44662.1 - 0.072 10.6 16.2 0.1 10.1 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ERM PF00769.19 PIK44662.1 - 0.18 11.6 18.5 0.024 14.4 14.1 1.8 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Lebercilin PF15619.6 PIK44662.1 - 0.22 11.2 22.3 0.37 10.4 22.0 1.6 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease PP_M1 PF03012.14 PIK44662.1 - 7.5 6.0 13.4 5 6.6 3.4 2.4 2 0 0 2 2 2 0 Phosphoprotein Siva PF05458.12 PIK44663.1 - 1.1e-28 100.1 7.7 1.3e-28 99.8 7.7 1.1 1 0 0 1 1 1 1 Cd27 binding protein (Siva) Peptidase_M28 PF04389.17 PIK44667.1 - 3.1e-26 92.3 0.0 4.5e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 PIK44667.1 - 4.8e-07 29.7 0.0 1.6e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 T4BSS_DotH_IcmK PF12293.8 PIK44667.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion COX16 PF14138.6 PIK44668.1 - 8.6e-24 83.9 0.1 8.6e-24 83.9 0.1 1.4 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein COX16 SART-1 PF03343.13 PIK44669.1 - 1.4e-139 466.5 54.1 1.4e-139 466.5 54.1 2.1 2 0 0 2 2 2 1 SART-1 family RTBV_P12 PF06361.11 PIK44670.1 - 0.072 13.5 0.1 0.13 12.7 0.1 1.3 1 0 0 1 1 1 0 Rice tungro bacilliform virus P12 protein AAA_33 PF13671.6 PIK44671.1 - 4.5e-08 33.4 0.0 3.5e-07 30.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 PIK44671.1 - 0.00051 19.6 0.3 0.00051 19.6 0.3 1.9 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 PIK44671.1 - 0.00066 19.0 5.9 0.0049 16.2 1.1 3.2 2 1 0 2 2 2 1 Zeta toxin CPT PF07931.12 PIK44671.1 - 0.00079 19.3 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 PIK44671.1 - 0.012 15.9 0.2 0.045 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK44671.1 - 0.013 15.9 0.1 0.058 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 PIK44671.1 - 0.034 14.7 0.0 0.034 14.7 0.0 2.3 2 0 0 2 2 1 0 AAA domain KAP_NTPase PF07693.14 PIK44671.1 - 0.059 12.6 0.1 0.059 12.6 0.1 1.7 2 0 0 2 2 2 0 KAP family P-loop domain AAA PF00004.29 PIK44671.1 - 0.071 13.5 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 PIK44671.1 - 0.21 11.7 0.0 0.43 10.7 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_17 PF13207.6 PIK44671.1 - 0.22 12.0 0.0 0.22 12.0 0.0 3.5 4 0 0 4 4 3 0 AAA domain LETM1 PF07766.13 PIK44671.1 - 3.4 6.9 8.2 0.053 12.9 0.5 1.8 2 0 0 2 2 2 0 LETM1-like protein Homeodomain PF00046.29 PIK44672.1 - 8.8e-21 73.5 2.5 8.8e-21 73.5 2.5 1.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 PIK44672.1 - 0.0032 17.3 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK44672.1 - 0.019 14.5 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Porphobil_deam PF01379.20 PIK44672.1 - 0.05 13.1 0.2 0.07 12.6 0.2 1.3 1 1 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain YdaS_antitoxin PF15943.5 PIK44672.1 - 0.054 13.4 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT NACHT PF05729.12 PIK44673.1 - 1.8e-15 57.3 0.0 1.3e-14 54.5 0.0 2.2 2 0 0 2 2 2 1 NACHT domain ZZ PF00569.17 PIK44673.1 - 0.00073 19.3 8.8 0.00073 19.3 8.8 2.1 2 0 0 2 2 2 1 Zinc finger, ZZ type AAA_25 PF13481.6 PIK44673.1 - 0.0033 17.0 0.0 0.0084 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK44673.1 - 0.0043 16.3 0.0 0.0081 15.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 PIK44673.1 - 0.012 14.8 0.1 0.073 12.2 0.1 2.0 1 1 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 PIK44673.1 - 0.041 14.3 0.0 0.093 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 PIK44673.1 - 0.069 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) zf-UBR PF02207.20 PIK44673.1 - 0.076 13.2 4.0 0.27 11.4 4.0 2.0 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) AAA_18 PF13238.6 PIK44673.1 - 0.088 13.3 0.0 0.22 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK44673.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 PIK44673.1 - 0.1 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain CEBP_ZZ PF16366.5 PIK44673.1 - 0.11 12.7 4.5 0.35 11.1 4.5 1.8 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain AAA PF00004.29 PIK44673.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 PIK44673.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 PIK44673.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PDDEXK_1 PF12705.7 PIK44674.1 - 5.1e-05 23.3 0.9 7.4e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily Cadherin_tail PF15974.5 PIK44674.1 - 0.027 14.8 0.7 0.07 13.5 0.7 1.6 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Methyltransf_11 PF08241.12 PIK44675.1 - 8.1e-15 55.3 0.0 2.8e-14 53.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK44675.1 - 1.6e-13 50.7 0.0 2.7e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK44675.1 - 2.5e-13 50.5 0.0 4.7e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK44675.1 - 8.4e-10 39.3 0.0 1.6e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK44675.1 - 4.9e-09 35.9 0.0 6.8e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPMT PF05724.11 PIK44675.1 - 7.3e-05 22.5 0.0 0.00013 21.8 0.0 1.4 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 PIK44675.1 - 0.00016 21.6 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK44675.1 - 0.00033 20.3 0.0 0.00049 19.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK44675.1 - 0.013 15.0 0.0 0.04 13.4 0.0 1.9 1 1 0 1 1 1 0 Putative methyltransferase PCMT PF01135.19 PIK44675.1 - 0.017 14.9 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Rap_GAP PF02145.15 PIK44677.1 - 1.7e-12 47.3 0.0 3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP MOZ_SAS PF01853.18 PIK44677.1 - 0.007 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family Rap_GAP PF02145.15 PIK44678.1 - 2.9e-31 108.5 0.1 4.6e-31 107.8 0.1 1.2 1 0 0 1 1 1 1 Rap/ran-GAP PDZ_6 PF17820.1 PIK44678.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 PIK44678.1 - 0.046 14.1 0.0 0.088 13.2 0.0 1.5 1 0 0 1 1 1 0 PDZ domain MDFI PF15316.6 PIK44679.1 - 0.057 13.5 3.9 0.075 13.1 3.9 1.2 1 0 0 1 1 1 0 MyoD family inhibitor NST1 PF13945.6 PIK44679.1 - 0.061 13.4 7.7 0.082 13.0 7.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SPAR_C PF11881.8 PIK44680.1 - 8.6e-19 68.4 2.5 8.6e-19 68.4 2.5 2.6 2 1 0 2 2 2 1 C-terminal domain of SPAR protein Lzipper-MIP1 PF14389.6 PIK44680.1 - 0.0032 17.7 4.1 0.01 16.1 4.1 1.8 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 Ribosomal_L29 PF00831.23 PIK44680.1 - 0.047 13.7 3.2 0.14 12.2 3.2 1.9 1 0 0 1 1 1 0 Ribosomal L29 protein OmpH PF03938.14 PIK44680.1 - 1.3 9.3 8.5 3 8.2 8.5 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 PIK44680.1 - 1.7 8.9 11.3 0.34 11.1 6.8 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) IFP_35_N PF07334.13 PIK44680.1 - 2.6 8.2 6.5 9.9 6.3 4.6 2.6 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Alba PF01918.21 PIK44681.1 - 2.6e-09 36.8 0.0 3.7e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 PIK44681.1 - 2.9e-08 33.7 0.1 0.00017 21.5 0.0 2.1 1 1 1 2 2 2 2 Rpp20 subunit of nuclear RNase MRP and P Pkinase PF00069.25 PIK44682.1 - 2.7e-64 217.1 8.7 5.7e-36 124.2 0.0 4.3 4 1 1 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44682.1 - 1.3e-35 123.0 8.6 1.2e-13 50.9 0.0 4.9 4 1 1 5 5 5 4 Protein tyrosine kinase tRNA-synt_His PF13393.6 PIK44682.1 - 9.1e-17 61.3 5.0 2.8e-16 59.7 0.0 2.8 3 0 0 3 3 3 1 Histidyl-tRNA synthetase RWD PF05773.22 PIK44682.1 - 9.3e-16 58.2 0.0 5.7e-15 55.6 0.0 2.5 1 0 0 1 1 1 1 RWD domain HGTP_anticodon2 PF12745.7 PIK44682.1 - 4.1e-12 46.2 0.1 4.1e-12 46.2 0.1 2.6 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Kinase-like PF14531.6 PIK44682.1 - 0.00024 20.5 0.0 0.38 10.0 0.0 3.1 2 1 0 2 2 2 2 Kinase-like Elf4 PF07011.11 PIK44682.1 - 0.02 14.8 0.1 0.055 13.4 0.1 1.7 1 0 0 1 1 1 0 Early Flowering 4 domain FTA2 PF13095.6 PIK44682.1 - 0.032 13.9 4.6 0.14 11.8 0.0 3.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF3340 PF11818.8 PIK44682.1 - 0.17 12.1 13.0 0.58 10.3 13.0 1.9 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) DUF5401 PF17380.2 PIK44682.1 - 0.22 9.5 16.9 0.39 8.7 16.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Plasmodium_Vir PF05795.11 PIK44682.1 - 0.56 9.6 8.9 1.6 8.0 8.9 1.7 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Auto_anti-p27 PF06677.12 PIK44683.1 - 6e-08 32.7 1.3 1e-07 31.9 1.3 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.17 PIK44683.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Vasculin PF15337.6 PIK44683.1 - 0.44 11.4 0.1 0.44 11.4 0.1 2.6 2 1 1 3 3 3 0 Vascular protein family Vasculin-like 1 PH PF00169.29 PIK44684.1 - 9.3e-15 55.0 0.6 1.2e-14 54.6 0.6 1.2 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 PIK44684.1 - 0.0069 16.8 1.0 0.18 12.2 0.0 2.1 1 1 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 PIK44684.1 - 0.019 15.4 3.8 0.56 10.6 3.8 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain Mis14 PF08641.12 PIK44685.1 - 1.8e-07 31.5 0.5 5.3e-07 30.0 0.5 1.8 1 0 0 1 1 1 1 Kinetochore protein Mis14 like BTB PF00651.31 PIK44686.1 - 2.8e-31 108.0 0.8 8.6e-31 106.5 0.5 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK44686.1 - 3.9e-25 87.9 4.4 3.9e-25 87.9 4.4 2.6 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.8 PIK44686.1 - 6.1e-05 23.1 1.3 0.12 12.5 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3342) Acetyltransf_2 PF00797.17 PIK44687.1 - 2.1e-05 24.4 0.7 4e-05 23.5 0.7 1.4 1 1 0 1 1 1 1 N-acetyltransferase Ecm29 PF13001.7 PIK44688.1 - 6.6e-106 354.9 4.8 1.1e-56 192.6 0.3 4.6 4 1 1 5 5 5 2 Proteasome stabiliser Vac14_Fab1_bd PF12755.7 PIK44688.1 - 9.1e-13 48.6 0.0 0.0034 17.9 0.2 8.0 8 1 1 9 9 9 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 PIK44688.1 - 5.1e-11 42.8 14.6 0.013 16.0 0.0 11.1 13 0 0 13 13 13 2 HEAT-like repeat HEAT PF02985.22 PIK44688.1 - 2.9e-09 36.4 15.5 0.16 12.3 0.1 10.4 9 0 0 9 9 9 2 HEAT repeat HEAT_2 PF13646.6 PIK44688.1 - 8.2e-08 32.5 8.5 0.34 11.3 0.0 9.5 10 2 1 11 11 11 1 HEAT repeats SAM_KSR1 PF13543.6 PIK44688.1 - 0.044 13.9 0.1 0.19 11.9 0.1 2.1 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 VHS PF00790.19 PIK44688.1 - 0.05 13.4 1.6 9.9 6.0 0.0 4.2 4 1 0 4 4 4 0 VHS domain MMS19_N PF14500.6 PIK44688.1 - 0.61 9.6 3.3 72 2.8 0.0 5.2 5 1 0 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 PIK44688.1 - 1.2 8.2 16.5 4.9 6.1 1.7 5.5 6 0 0 6 6 6 0 RNAPII transcription regulator C-terminal 7tm_1 PF00001.21 PIK44689.1 - 2.4e-11 43.5 4.5 5.3e-11 42.3 4.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK44689.1 - 3.7e-05 23.5 0.3 3.7e-05 23.5 0.3 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK44689.1 - 0.0026 17.3 1.1 0.0094 15.5 0.1 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srsx PF10320.9 PIK44689.1 - 0.0058 16.0 3.6 0.012 15.0 0.6 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx HydF_tetramer PF18133.1 PIK44689.1 - 0.029 14.1 0.1 0.089 12.5 0.0 1.8 1 1 1 2 2 2 0 Hydrogen maturase F tetramerization domain 7TM_GPCR_Srab PF10292.9 PIK44689.1 - 0.061 12.2 1.0 0.085 11.8 1.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Membralin PF09746.9 PIK44690.1 - 5.7e-127 423.9 4.4 2.5e-126 421.8 4.4 1.8 1 1 0 1 1 1 1 Tumour-associated protein YXWGXW PF12779.7 PIK44690.1 - 0.15 12.2 2.1 1 9.5 0.1 2.6 2 0 0 2 2 2 0 YXWGXW repeat (2 copies) zf-GRF PF06839.12 PIK44691.1 - 3.5e-30 103.8 13.0 3.1e-17 62.4 2.8 3.4 4 0 0 4 4 4 2 GRF zinc finger Topoisom_bac PF01131.20 PIK44691.1 - 1.2e-25 90.4 0.0 1.6e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-C4_Topoisom PF01396.19 PIK44691.1 - 9.3e-09 34.9 0.8 9.3e-09 34.9 0.8 3.0 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.5 PIK44691.1 - 0.12 12.1 1.7 0.33 10.7 1.7 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 PIK44691.1 - 3.2 7.7 6.1 0.37 10.7 0.9 2.2 2 0 0 2 2 2 0 Zinc knuckle TMF_TATA_bd PF12325.8 PIK44693.1 - 9.2e-22 77.4 9.3 1.1e-21 77.2 9.3 1.0 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 PIK44693.1 - 0.0035 17.4 2.0 0.004 17.2 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) SPATA24 PF15175.6 PIK44693.1 - 0.0055 16.6 2.0 0.0062 16.5 2.0 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 Dynactin_p22 PF07426.11 PIK44693.1 - 0.0086 16.0 5.0 0.015 15.1 5.0 1.4 1 1 0 1 1 1 1 Dynactin subunit p22 SLATT_5 PF18160.1 PIK44693.1 - 0.031 13.6 1.2 0.06 12.7 1.2 1.6 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Cse1 PF08506.10 PIK44693.1 - 0.031 13.1 1.5 0.035 12.9 1.5 1.0 1 0 0 1 1 1 0 Cse1 Ran-binding PF05508.11 PIK44693.1 - 0.064 12.2 2.5 0.07 12.1 2.5 1.0 1 0 0 1 1 1 0 RanGTP-binding protein DUF948 PF06103.11 PIK44693.1 - 0.084 13.1 1.4 0.24 11.7 0.4 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 PIK44693.1 - 0.41 10.0 2.8 0.43 9.9 2.8 1.0 1 0 0 1 1 1 0 FAM76 protein zf-C4H2 PF10146.9 PIK44693.1 - 0.42 10.9 4.8 0.45 10.8 4.8 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein Lung_7-TM_R PF06814.13 PIK44694.1 - 1.2e-12 47.7 7.8 1.5e-12 47.4 7.8 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Spo7 PF03907.13 PIK44694.1 - 0.059 12.8 2.1 0.076 12.5 2.1 1.1 1 0 0 1 1 1 0 Spo7-like protein Ribonuclease_T2 PF00445.18 PIK44695.1 - 7.5e-50 169.7 8.5 1.2e-49 169.1 8.5 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family Spec3 PF15795.5 PIK44696.1 - 3e-25 88.6 13.2 4e-25 88.2 13.2 1.2 1 0 0 1 1 1 1 Ectodermal ciliogenesis protein DUF4233 PF14017.6 PIK44696.1 - 0.64 10.4 7.8 0.9 9.9 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4233) IgGFc_binding PF17517.2 PIK44697.1 - 2e-65 221.0 0.7 3e-65 220.4 0.7 1.3 1 0 0 1 1 1 1 IgGFc binding protein Orf78 PF06024.12 PIK44697.1 - 0.12 12.7 0.3 0.21 11.9 0.3 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Complex1_LYR PF05347.15 PIK44698.1 - 1e-08 35.1 0.6 3.4e-08 33.4 0.6 1.8 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Glyoxalase PF00903.25 PIK44699.1 - 3e-20 72.7 0.0 3.7e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 PIK44699.1 - 0.0001 22.5 0.0 0.00087 19.5 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 PIK44699.1 - 0.02 15.7 0.0 0.042 14.6 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase-like domain FAD_binding_3 PF01494.19 PIK44700.1 - 5.4e-19 68.6 0.3 9.9e-09 34.9 0.0 2.6 2 1 0 2 2 2 2 FAD binding domain SE PF08491.10 PIK44700.1 - 0.00025 20.2 0.0 0.00045 19.4 0.0 1.4 1 0 0 1 1 1 1 Squalene epoxidase NAD_binding_8 PF13450.6 PIK44700.1 - 0.00052 20.2 0.1 0.0014 18.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 PIK44700.1 - 0.0086 15.3 0.1 0.017 14.3 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK44700.1 - 0.009 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF5550 PF17704.1 PIK44700.1 - 0.019 15.1 0.0 0.068 13.3 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5550) Trp_halogenase PF04820.14 PIK44700.1 - 0.052 12.4 0.0 3.4 6.4 0.1 2.4 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 PIK44700.1 - 0.16 11.0 1.1 0.75 8.8 0.1 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein SpoU_methylase PF00588.19 PIK44701.1 - 2.8e-27 95.6 0.0 6.4e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family Cofilin_ADF PF00241.20 PIK44703.1 - 6.9e-30 103.3 0.1 8.2e-30 103.1 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein KilA-N PF04383.13 PIK44703.1 - 0.39 10.6 1.7 8 6.3 0.0 2.6 2 1 0 3 3 3 0 KilA-N domain DDE_Tnp_ISAZ013 PF07592.11 PIK44704.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.3 1 1 0 1 1 1 0 Rhodopirellula transposase DDE domain Patatin PF01734.22 PIK44706.1 - 1e-14 55.2 3.5 6.7e-14 52.6 3.5 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase EZH2_WD-Binding PF11616.8 PIK44707.1 - 0.2 11.8 1.0 11 6.2 0.2 2.3 2 0 0 2 2 2 0 WD repeat binding protein EZH2 zf-H2C2_2 PF13465.6 PIK44708.1 - 4.7e-42 140.6 44.8 9.8e-11 41.6 1.9 6.5 7 0 0 7 7 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK44708.1 - 4.4e-15 55.2 50.2 6.7e-05 23.1 1.7 7.0 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44708.1 - 5e-15 54.9 46.7 0.00065 20.3 1.2 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK44708.1 - 0.00019 21.3 37.8 0.0048 16.9 3.8 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger Siva PF05458.12 PIK44708.1 - 0.00095 18.9 4.8 0.19 11.4 0.1 3.1 1 1 2 3 3 3 2 Cd27 binding protein (Siva) zf-AN1 PF01428.16 PIK44708.1 - 0.0015 18.6 25.5 0.055 13.6 0.9 5.5 4 1 1 5 5 5 2 AN1-like Zinc finger zf-C2H2_jaz PF12171.8 PIK44708.1 - 0.005 17.1 40.9 0.12 12.7 0.9 6.2 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK44708.1 - 0.026 14.8 2.3 0.026 14.8 2.3 3.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.8 PIK44708.1 - 0.062 13.6 22.2 0.16 12.3 3.1 3.7 1 1 4 5 5 5 0 zinc-finger-containing domain zinc_ribbon_9 PF14369.6 PIK44708.1 - 0.083 13.2 7.6 34 4.8 0.1 4.5 3 1 1 4 4 4 0 zinc-ribbon PyrI_C PF02748.15 PIK44708.1 - 0.15 12.0 27.3 0.82 9.6 0.4 5.8 6 0 0 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_4 PF07975.12 PIK44708.1 - 0.25 11.6 28.6 0.057 13.7 3.4 4.6 1 1 5 6 6 6 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 PIK44708.1 - 2.4 8.1 18.4 16 5.5 0.1 5.3 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Peptidase_M14 PF00246.24 PIK44709.1 - 1.6e-19 70.8 0.0 3.8e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 PIK44709.1 - 9.9e-18 64.5 1.1 3.1e-17 62.9 1.1 1.9 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 PIK44709.1 - 0.0045 16.1 0.0 0.0088 15.1 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Tetraspanin PF00335.20 PIK44710.1 - 8.3e-40 136.9 15.6 9.6e-40 136.7 15.6 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF3367 PF11847.8 PIK44710.1 - 0.056 11.3 0.7 0.084 10.7 0.7 1.2 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase DUF3139 PF11337.8 PIK44710.1 - 0.39 11.4 0.1 0.39 11.4 0.1 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) Prion_bPrPp PF11587.8 PIK44710.1 - 0.43 10.4 2.6 0.6 10.0 0.9 2.2 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal Stealth_CR2 PF11380.8 PIK44711.1 - 9.9e-45 151.2 0.0 1.8e-44 150.3 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Notch PF00066.17 PIK44711.1 - 7.6e-15 55.1 35.5 7.6e-09 35.9 13.4 2.4 2 0 0 2 2 2 2 LNR domain Stealth_CR1 PF17101.5 PIK44711.1 - 2e-12 46.6 0.0 3.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 PIK44712.1 - 2.8e-22 78.3 0.5 6.7e-22 77.1 0.5 1.7 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 FGE-sulfatase PF03781.16 PIK44713.1 - 4.8e-68 229.6 3.8 5.2e-68 229.4 3.8 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 SET PF00856.28 PIK44714.1 - 3.1e-23 83.0 0.1 4.8e-22 79.1 0.1 2.1 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 PIK44714.1 - 1.6e-08 35.2 11.2 1.1e-07 32.5 8.5 2.3 2 0 0 2 2 2 1 Pre-SET motif AWS PF17907.1 PIK44714.1 - 0.014 15.5 4.4 0.014 15.5 4.4 3.1 3 0 0 3 3 3 0 AWS domain Metallothio_Euk PF12749.7 PIK44714.1 - 0.59 10.3 15.1 4.4 7.5 0.5 3.3 3 0 0 3 3 3 0 Eukaryotic metallothionein LRR_8 PF13855.6 PIK44716.1 - 2.3e-26 91.3 32.8 6.4e-11 41.9 2.5 5.4 2 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 PIK44716.1 - 6.5e-18 64.5 44.0 0.00054 20.3 1.7 7.4 5 2 4 9 9 9 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44716.1 - 3.8e-05 23.3 16.3 0.031 13.8 2.1 4.2 1 1 4 5 5 5 4 Leucine-rich repeat SCAN PF02023.17 PIK44716.1 - 0.13 12.1 0.1 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 SCAN domain LRR_5 PF13306.6 PIK44716.1 - 0.21 11.5 0.2 31 4.5 0.1 2.6 1 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) PDZ PF00595.24 PIK44717.1 - 5e-70 231.9 8.4 6.9e-18 64.8 0.0 4.9 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK44717.1 - 1.2e-28 98.7 10.4 2e-07 30.8 0.0 5.3 5 0 0 5 5 5 4 PDZ domain PDZ_2 PF13180.6 PIK44717.1 - 3.2e-17 62.6 8.2 1.5e-05 25.2 0.3 5.4 6 1 1 7 7 7 4 PDZ domain PUF PF00806.19 PIK44718.1 - 3e-53 174.6 4.3 6.8e-12 44.4 0.0 5.2 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat sCache_2 PF17200.4 PIK44718.1 - 0.0054 16.6 0.1 7.9 6.3 0.0 3.1 3 0 0 3 3 3 1 Single Cache domain 2 CPL PF08144.11 PIK44718.1 - 0.025 14.9 0.0 3.6 7.9 0.0 3.3 1 1 1 2 2 2 0 CPL (NUC119) domain DUF4821 PF16092.5 PIK44718.1 - 0.064 12.9 0.1 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4821) AdoMet_MTase PF07757.13 PIK44718.1 - 0.12 12.7 0.1 25 5.3 0.0 2.7 3 0 0 3 3 3 0 Predicted AdoMet-dependent methyltransferase Importin_rep_3 PF18806.1 PIK44718.1 - 0.14 12.2 0.3 1.4 9.0 0.0 2.5 1 1 1 2 2 2 0 Importin 13 repeat Mt_ATP-synt_B PF05405.14 PIK44718.1 - 0.16 11.6 2.6 7.1 6.2 0.0 3.1 3 1 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF445 PF04286.12 PIK44718.1 - 0.17 11.6 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AAA_18 PF13238.6 PIK44721.1 - 0.024 15.2 0.0 0.031 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 PIK44721.1 - 0.032 13.2 0.1 0.036 13.0 0.1 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 PIK44721.1 - 0.035 14.5 0.0 0.039 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.22 PIK44721.1 - 0.053 13.1 0.2 0.079 12.5 0.2 1.3 1 0 0 1 1 1 0 Ras family DAP3 PF10236.9 PIK44721.1 - 0.071 12.3 0.0 0.077 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 PIK44721.1 - 0.12 11.9 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 PIK44721.1 - 0.14 12.4 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ACOX PF01756.19 PIK44722.1 - 1.8e-33 115.6 0.0 3.1e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 PIK44722.1 - 2.5e-28 99.1 1.5 5.2e-28 98.1 1.5 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 PIK44722.1 - 5.9e-12 45.6 0.0 1.4e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 PIK44722.1 - 0.022 15.0 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain ECR1_N PF14382.6 PIK44722.1 - 0.22 11.4 1.9 0.62 9.9 1.9 1.8 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region SOGA PF11365.8 PIK44723.1 - 7.2e-17 62.3 88.3 1.2e-10 42.4 3.9 9.8 6 4 1 9 9 9 6 Protein SOGA SSF PF00474.17 PIK44724.1 - 1.8e-35 122.6 13.3 7.6e-25 87.6 10.7 2.1 1 1 1 2 2 2 2 Sodium:solute symporter family LKAAEAR PF15478.6 PIK44725.1 - 1e-43 148.9 9.4 1.2e-43 148.6 9.4 1.0 1 0 0 1 1 1 1 Family of unknown function with LKAAEAR motif DUF1204 PF06721.11 PIK44725.1 - 0.0083 15.6 4.4 0.011 15.2 4.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1204) DUF4790 PF16037.5 PIK44725.1 - 0.085 13.3 0.4 0.085 13.3 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4790) SPATIAL PF15256.6 PIK44725.1 - 1.1 9.6 6.1 0.99 9.7 4.1 1.7 1 1 1 2 2 2 0 SPATIAL Ubiquitin_4 PF18036.1 PIK44726.1 - 2.7e-27 94.7 0.8 4.1e-27 94.1 0.8 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 PIK44726.1 - 0.014 15.1 0.0 4.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin family Lipase PF00151.19 PIK44729.1 - 1.4e-50 172.5 0.0 1.7e-50 172.3 0.0 1.0 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 PIK44729.1 - 0.056 14.1 0.2 0.095 13.3 0.2 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 PIK44729.1 - 0.059 13.2 0.0 1.4 8.7 0.0 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase PF00151.19 PIK44730.1 - 2.3e-74 250.7 0.0 2.9e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 Lipase zf-C2HC_2 PF13913.6 PIK44731.1 - 1.9e-16 59.5 10.7 8.5e-09 35.1 2.3 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type YacG PF03884.14 PIK44731.1 - 0.011 15.5 1.8 0.011 15.5 1.8 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG XAF1_C PF18608.1 PIK44731.1 - 0.023 14.2 0.4 0.063 12.8 0.4 1.7 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain Rad50_zn_hook PF04423.14 PIK44731.1 - 0.035 13.9 3.6 2.3 8.2 0.8 2.8 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C2H2 PF00096.26 PIK44731.1 - 0.037 14.5 3.1 6.6 7.4 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44731.1 - 0.039 14.8 9.3 1.3 10.1 1.6 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-CpG_bind_C PF12269.8 PIK44731.1 - 0.047 13.5 3.8 0.81 9.4 0.1 2.1 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain FYDLN_acid PF09538.10 PIK44731.1 - 0.099 13.3 4.8 2.3 8.9 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.12 PIK44731.1 - 0.12 12.6 6.8 1.5 9.2 0.9 2.5 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 PIK44731.1 - 0.17 12.2 5.5 4.6 7.6 0.9 2.6 2 0 0 2 2 2 0 zinc-ribbon GcpE PF04551.14 PIK44731.1 - 0.41 9.7 2.5 6 5.9 0.1 2.2 2 0 0 2 2 2 0 GcpE protein Sgf11 PF08209.11 PIK44731.1 - 1.5 8.4 6.3 0.76 9.4 0.2 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Cys_rich_CPCC PF14206.6 PIK44731.1 - 3.5 7.5 7.1 0.53 10.1 0.9 2.4 2 1 0 2 2 2 0 Cysteine-rich CPCC zf-RING_7 PF02591.15 PIK44731.1 - 4.4 7.6 7.0 9.1 6.6 0.4 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf-B_box PF00643.24 PIK44733.1 - 0.0019 18.3 14.2 0.002 18.2 9.1 2.6 2 0 0 2 2 2 1 B-box zinc finger BBS1 PF14779.6 PIK44733.1 - 0.037 13.5 4.3 0.46 9.9 0.0 2.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 Alpha-amylase PF00128.24 PIK44733.1 - 0.51 9.8 5.6 0.86 9.1 5.6 1.3 1 0 0 1 1 1 0 Alpha amylase, catalytic domain DUF1664 PF07889.12 PIK44733.1 - 0.51 10.4 5.9 0.62 10.1 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 PIK44733.1 - 1.5 9.2 4.5 0.55 10.7 0.9 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 PIK44733.1 - 2.2 7.6 11.1 3.2 7.0 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 PIK44733.1 - 3 7.3 8.2 5 6.6 8.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fibrinogen_C PF00147.18 PIK44734.1 - 4.7e-43 147.6 11.3 7.8e-43 146.8 11.3 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK44734.1 - 1e-07 31.8 11.5 1e-07 31.8 11.5 4.5 3 2 2 5 5 5 1 TILa domain TIL PF01826.17 PIK44734.1 - 2.8e-07 30.7 15.8 2.8e-07 30.7 15.8 5.2 4 2 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK44734.1 - 0.0021 18.2 13.8 0.0021 18.2 13.8 5.0 4 2 0 4 4 4 1 EGF domain Tubulin_C PF03953.17 PIK44735.1 - 2.5e-28 98.8 0.0 3.7e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Suv3_N PF18114.1 PIK44735.1 - 0.01 15.9 0.1 0.024 14.8 0.1 1.5 1 0 0 1 1 1 0 Suv3 helical N-terminal domain Tubulin PF00091.25 PIK44736.1 - 1.6e-44 152.5 0.0 2.3e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 PIK44736.1 - 0.02 14.1 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 Tubulin like Antimicrobial12 PF08107.11 PIK44736.1 - 2.7 7.8 26.1 17 5.3 0.3 7.2 7 0 0 7 7 7 0 Pleurocidin family GCD14 PF08704.10 PIK44737.1 - 0.072 12.8 0.2 0.09 12.4 0.2 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit zf-H2C2_2 PF13465.6 PIK44738.1 - 3e-39 131.7 64.8 6.8e-08 32.6 0.3 10.5 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK44738.1 - 4.5e-38 127.6 70.7 4.5e-06 26.8 1.5 9.5 10 0 0 10 10 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44738.1 - 9.4e-17 60.3 76.5 0.0033 18.1 1.6 9.8 11 0 0 11 11 8 7 C2H2-type zinc finger zf-met PF12874.7 PIK44738.1 - 1.2e-11 44.6 37.5 0.077 13.4 0.3 7.9 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 PIK44738.1 - 1.1e-10 41.1 32.8 0.039 13.9 0.3 8.5 8 0 0 8 8 8 4 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK44738.1 - 6.9e-10 38.5 39.2 0.00028 20.6 0.3 8.4 8 0 0 8 8 8 4 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 PIK44738.1 - 1.3e-09 37.9 70.8 0.0044 17.0 1.1 10.9 9 3 0 9 9 9 6 C2H2-type zinc finger SET PF00856.28 PIK44738.1 - 2.1e-06 28.2 0.4 4.4e-05 23.9 0.4 2.4 1 1 0 1 1 1 1 SET domain Zn-ribbon_8 PF09723.10 PIK44738.1 - 2.1e-06 27.7 34.7 0.11 12.7 3.1 7.4 3 1 5 8 8 8 6 Zinc ribbon domain zf_UBZ PF18439.1 PIK44738.1 - 2.5e-06 26.9 29.6 3.2 7.4 0.1 8.2 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 PIK44738.1 - 2.7e-06 27.5 25.8 0.58 10.5 0.4 7.8 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding DUF2688 PF10892.8 PIK44738.1 - 4.2e-05 22.9 16.2 9.8 5.7 0.1 6.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2688) C1_4 PF07975.12 PIK44738.1 - 0.00057 20.1 31.4 0.082 13.2 1.1 6.8 4 1 5 9 9 8 4 TFIIH C1-like domain zf-trcl PF13451.6 PIK44738.1 - 0.00057 19.7 35.4 3.7 7.5 0.1 8.3 9 0 0 9 9 8 5 Probable zinc-ribbon domain ADK_lid PF05191.14 PIK44738.1 - 0.00062 19.7 24.2 5.8 7.0 0.2 7.2 5 2 2 7 7 7 2 Adenylate kinase, active site lid DUF3268 PF11672.8 PIK44738.1 - 0.019 15.3 14.9 1.3 9.3 1.2 4.8 4 1 0 5 5 4 0 zinc-finger-containing domain zf-C2H2_3rep PF18868.1 PIK44738.1 - 0.033 14.9 30.9 0.63 10.7 3.7 6.5 3 1 0 4 4 4 0 Zinc finger C2H2-type, 3 repeats CpXC PF14353.6 PIK44738.1 - 0.034 14.2 24.9 6 6.9 0.1 7.4 6 1 2 8 8 8 0 CpXC protein zf-C4_ClpX PF06689.13 PIK44738.1 - 0.044 13.7 18.4 7.3 6.6 0.1 7.2 8 0 0 8 8 7 0 ClpX C4-type zinc finger zinc_ribbon_15 PF17032.5 PIK44738.1 - 0.67 10.7 35.5 0.42 11.4 1.8 5.4 5 1 1 6 6 6 0 zinc-ribbon family zinc_ribbon_4 PF13717.6 PIK44738.1 - 0.75 9.8 31.2 1.6 8.7 3.0 7.2 6 2 0 6 6 6 0 zinc-ribbon domain FYVE PF01363.21 PIK44738.1 - 2.2 8.5 34.1 0.37 11.0 0.8 5.3 3 1 2 5 5 5 0 FYVE zinc finger zf_ZIC PF18366.1 PIK44738.1 - 5.7 7.1 27.6 24 5.2 0.1 6.8 2 1 5 7 7 7 0 Zic proteins zinc finger domain Phosducin PF02114.16 PIK44739.1 - 1.3e-16 60.4 0.1 1.6e-16 60.0 0.1 1.1 1 0 0 1 1 1 1 Phosducin Aminotran_5 PF00266.19 PIK44740.1 - 1.5e-07 30.8 0.0 2.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 PIK44740.1 - 0.099 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1356 PF07092.12 PIK44741.1 - 0.0086 15.4 0.7 0.012 14.9 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) BRICHOS PF04089.14 PIK44743.1 - 0.0063 16.7 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain ETRAMP PF09716.10 PIK44743.1 - 2.3 8.4 4.5 0.55 10.3 0.2 2.1 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RVT_1 PF00078.27 PIK44744.1 - 2.4e-29 102.4 0.1 2.7e-29 102.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CoxIIa PF08113.11 PIK44745.1 - 0.0023 17.7 2.4 0.004 16.9 2.4 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IIa family BRICHOS PF04089.14 PIK44745.1 - 0.017 15.3 0.0 0.052 13.8 0.0 1.9 1 1 0 1 1 1 0 BRICHOS domain RT_RNaseH_2 PF17919.1 PIK44746.1 - 2.1e-11 43.7 0.0 6.9e-10 38.9 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44746.1 - 1.3e-10 41.2 0.2 4.1e-10 39.6 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK44746.1 - 0.1 12.9 0.1 4.8 7.5 0.0 2.3 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK44747.1 - 7.4e-19 68.1 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44747.1 - 6.6e-06 26.1 0.0 1.4e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44747.1 - 0.00015 21.4 0.4 0.00051 19.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK44747.1 - 0.027 14.7 0.0 0.051 13.8 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger IgGFc_binding PF17517.2 PIK44748.1 - 4.6e-37 127.9 2.5 7e-37 127.3 2.5 1.2 1 0 0 1 1 1 1 IgGFc binding protein PH PF00169.29 PIK44750.1 - 5.4e-16 59.0 0.3 1.3e-15 57.8 0.0 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 PIK44750.1 - 0.011 16.2 0.7 0.011 16.2 0.7 2.3 2 2 0 2 2 2 0 Pleckstrin homology domain DUF896 PF05979.12 PIK44750.1 - 0.76 9.7 10.9 0.28 11.1 7.8 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF896) Pkinase PF00069.25 PIK44752.1 - 3.6e-65 220.0 0.0 4.2e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44752.1 - 3.8e-24 85.4 0.0 5.2e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK44752.1 - 1.5e-06 27.7 0.0 3.7e-05 23.2 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 PIK44752.1 - 0.00079 19.4 0.0 0.0054 16.7 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK44752.1 - 0.0039 16.6 0.0 0.0059 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK44752.1 - 0.027 14.1 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC1 PF03109.16 PIK44752.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Annexin_like PF18411.1 PIK44752.1 - 0.11 12.8 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Annexin-like domain Gal-3-0_sulfotr PF06990.11 PIK44753.1 - 9.2e-52 176.3 1.4 1.1e-51 176.0 1.4 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase PA28_beta PF02252.18 PIK44753.1 - 0.037 13.7 0.3 0.097 12.3 0.1 1.7 2 0 0 2 2 2 0 Proteasome activator pa28 beta subunit HSP70 PF00012.20 PIK44755.1 - 5.5e-86 289.1 24.3 5.5e-86 289.1 24.3 3.9 2 1 2 4 4 4 2 Hsp70 protein MreB_Mbl PF06723.13 PIK44755.1 - 0.00017 20.5 0.9 0.0034 16.3 0.1 2.3 2 0 0 2 2 2 2 MreB/Mbl protein XRCC1_N PF01834.16 PIK44756.1 - 9.7e-66 220.3 0.2 2.2e-65 219.2 0.2 1.6 1 0 0 1 1 1 1 XRCC1 N terminal domain BRCT_2 PF16589.5 PIK44756.1 - 1.4e-10 41.4 2.0 6.8e-05 23.2 0.0 3.3 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK44756.1 - 7.2e-10 39.1 0.0 1.4e-07 31.8 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 PIK44756.1 - 4.2e-08 33.0 0.0 9.7e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain ZU5 PF00791.20 PIK44757.1 - 1.2e-11 44.8 0.0 2.8e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK44757.1 - 3.6e-10 39.9 0.3 1.3e-09 38.0 0.5 1.9 2 0 0 2 2 2 1 Death domain LprI PF07007.12 PIK44757.1 - 0.097 13.3 1.0 10 6.9 0.1 2.5 2 0 0 2 2 2 0 Lysozyme inhibitor LprI PapC_C PF13953.6 PIK44757.1 - 1.4 8.8 3.5 27 4.7 0.3 2.4 2 0 0 2 2 2 0 PapC C-terminal domain DUF1891 PF09004.10 PIK44758.1 - 0.017 14.7 0.0 0.11 12.1 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1891) DUF1256 PF06866.11 PIK44758.1 - 0.066 12.6 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) RNA_pol_Rpb2_7 PF04560.20 PIK44759.1 - 3.3e-22 78.7 0.1 4.3e-22 78.3 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_6 PF00562.28 PIK44760.1 - 2.4e-54 184.9 0.0 2.9e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_5 PF04567.17 PIK44760.1 - 4.1e-10 40.1 4.1 4.1e-10 40.1 4.1 2.8 2 2 0 2 2 2 1 RNA polymerase Rpb2, domain 5 DUF2213 PF09979.9 PIK44760.1 - 0.071 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2213) RNA_pol_Rpb2_2 PF04561.14 PIK44761.1 - 3.7e-23 82.1 0.0 5e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.15 PIK44761.1 - 0.0038 16.8 0.0 0.0039 16.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_1 PF04563.15 PIK44762.1 - 1e-49 168.8 0.0 1.2e-49 168.6 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase beta subunit THAP PF05485.12 PIK44765.1 - 1.5e-15 57.9 2.5 3.4e-15 56.7 2.5 1.6 1 0 0 1 1 1 1 THAP domain HTH_Tnp_4 PF13613.6 PIK44765.1 - 0.009 15.7 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease betaPIX_CC PF16523.5 PIK44766.1 - 0.021 14.6 1.9 0.05 13.4 1.9 1.6 1 0 0 1 1 1 0 betaPIX coiled coil SPX PF03105.19 PIK44766.1 - 0.022 14.7 7.8 0.037 14.0 7.8 1.4 1 1 0 1 1 1 0 SPX domain Swi5 PF07061.11 PIK44766.1 - 0.028 14.5 2.7 0.072 13.2 2.7 1.7 1 0 0 1 1 1 0 Swi5 Peptidase_S46 PF10459.9 PIK44766.1 - 0.056 12.1 1.1 0.069 11.8 1.1 1.2 1 0 0 1 1 1 0 Peptidase S46 Lzipper-MIP1 PF14389.6 PIK44766.1 - 0.068 13.5 3.6 0.22 11.9 3.6 2.0 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 PRP1_N PF06424.12 PIK44766.1 - 0.094 13.1 3.0 0.13 12.6 3.0 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4988 PF16378.5 PIK44766.1 - 0.12 12.0 1.0 0.19 11.4 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function WD40_alt PF14077.6 PIK44766.1 - 0.23 11.4 3.2 0.31 10.9 0.8 2.2 2 0 0 2 2 2 0 Alternative WD40 repeat motif FlaC_arch PF05377.11 PIK44766.1 - 0.6 10.5 4.1 1.7 9.1 4.1 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 PIK44766.1 - 0.67 9.8 5.2 2.9 7.7 5.1 2.0 1 1 0 1 1 1 0 Septum formation initiator IFP_35_N PF07334.13 PIK44766.1 - 0.99 9.5 6.6 3.1 7.9 6.6 2.0 1 1 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus PNMA PF14893.6 PIK44767.1 - 2.9e-11 43.3 0.1 3.5e-11 43.1 0.1 1.0 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK44767.1 - 0.00075 19.7 0.1 0.0027 17.9 0.0 2.0 1 1 1 2 2 2 1 Retrotransposon gag protein RVT_1 PF00078.27 PIK44768.1 - 1.6e-27 96.5 0.0 3.4e-27 95.4 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44768.1 - 2.1e-27 95.1 0.0 3.9e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44768.1 - 2.2e-22 79.3 0.0 4.5e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK44769.1 - 8.8e-17 61.4 0.0 1.3e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK44769.1 - 0.00054 19.7 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 PIK44770.1 - 7e-16 58.5 0.0 9e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK44770.1 - 0.0018 18.0 0.0 0.0037 17.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK44772.1 - 7.2e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK44772.1 - 1.2e-12 48.2 1.4 2.2e-10 40.9 0.1 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK44772.1 - 3.5e-11 43.6 1.5 5.6e-08 33.3 0.3 2.4 2 0 0 2 2 2 2 Aspartyl protease Asp_protease PF09668.10 PIK44772.1 - 0.0039 17.0 0.0 0.019 14.7 0.0 2.0 1 1 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK44772.1 - 0.0057 16.9 0.0 0.02 15.2 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 PIK44772.1 - 0.056 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RT_RNaseH_2 PF17919.1 PIK44773.1 - 8.7e-36 122.0 0.1 1.4e-35 121.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44773.1 - 4.9e-34 116.8 0.1 9.2e-34 115.9 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 PIK44773.1 - 0.018 15.0 0.1 0.038 14.0 0.1 1.5 1 0 0 1 1 1 0 Pao retrotransposon peptidase Glyco_transf_29 PF00777.18 PIK44778.1 - 2.1e-43 148.7 0.2 3.1e-43 148.1 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DUF2251 PF10008.9 PIK44778.1 - 0.08 13.0 0.2 0.2 11.8 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) Jiv90 PF14901.6 PIK44778.1 - 0.089 13.0 0.9 0.2 11.8 0.9 1.6 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone RET_CLD3 PF17812.1 PIK44778.1 - 0.14 12.4 0.8 0.35 11.1 0.1 1.9 2 0 0 2 2 2 0 RET Cadherin like domain 3 Forkhead PF00250.18 PIK44779.1 - 1.6e-37 127.6 0.0 3e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain Eryth_link_C PF16915.5 PIK44779.1 - 0.0036 17.3 0.0 0.0069 16.4 0.0 1.5 1 0 0 1 1 1 1 Annelid erythrocruorin linker subunit C-terminus cobW PF02492.19 PIK44780.1 - 6.3e-44 149.7 0.5 8.8e-44 149.2 0.5 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 PIK44780.1 - 0.00051 19.6 2.7 0.012 15.2 1.6 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK44780.1 - 0.0015 18.4 3.9 0.24 11.3 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase ABC_tran PF00005.27 PIK44780.1 - 0.11 13.0 0.3 0.31 11.6 0.0 1.8 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 PIK44780.1 - 0.12 12.4 0.3 0.87 9.7 0.2 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase SPX PF03105.19 PIK44781.1 - 0.0061 16.5 4.0 0.0082 16.1 4.0 1.1 1 0 0 1 1 1 1 SPX domain PAXIP1_C PF15364.6 PIK44781.1 - 0.0071 16.7 0.7 4 7.7 0.0 2.7 3 0 0 3 3 3 2 PAXIP1-associated-protein-1 C term PTIP binding protein Aft1_HRA PF11786.8 PIK44781.1 - 0.34 11.3 6.6 17 5.8 0.0 3.9 3 1 0 3 3 3 0 Aft1 HRA domain Peptidase_A17 PF05380.13 PIK44782.1 - 2.7e-57 193.3 0.0 4.7e-57 192.5 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase gag-asp_proteas PF13975.6 PIK44782.1 - 4.6e-07 30.3 0.0 1.6e-06 28.6 0.0 2.0 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK44782.1 - 3.9e-06 27.4 0.0 1.3e-05 25.7 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease DUF1759 PF03564.15 PIK44782.1 - 1.2e-05 25.3 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) RVT_1 PF00078.27 PIK44782.1 - 0.00018 21.1 0.0 0.0004 20.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44782.1 - 0.00021 21.3 0.0 0.0011 19.0 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44782.1 - 0.00053 20.2 0.1 0.0018 18.5 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44783.1 - 2.3e-19 69.8 0.0 6.3e-19 68.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK44783.1 - 0.026 14.4 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Med18 protein HYR PF02494.16 PIK44784.1 - 2.8e-41 139.7 16.9 8.9e-15 54.8 2.7 3.0 3 0 0 3 3 3 3 HYR domain HYR PF02494.16 PIK44785.1 - 1.9e-28 98.6 25.9 2.6e-19 69.3 6.2 2.8 3 0 0 3 3 3 2 HYR domain Big_8 PF17961.1 PIK44785.1 - 0.013 15.6 2.2 0.027 14.6 0.9 2.0 2 0 0 2 2 2 0 Bacterial Ig domain Big_3_3 PF13750.6 PIK44785.1 - 0.021 14.5 5.6 1.6 8.3 0.3 3.2 1 1 2 3 3 3 0 Bacterial Ig-like domain (group 3) HYR PF02494.16 PIK44786.1 - 8.3e-81 266.4 72.1 1.7e-18 66.7 6.1 7.0 7 0 0 7 7 7 7 HYR domain Big_3_4 PF13754.6 PIK44786.1 - 2.5e-07 30.4 1.6 4.9 7.0 0.0 4.8 4 0 0 4 4 4 4 Domain of unknown function MucBP PF06458.12 PIK44786.1 - 0.00052 21.0 6.6 0.51 11.4 0.2 3.7 3 0 0 3 3 3 2 MucBP domain DUF4609 PF15382.6 PIK44786.1 - 0.00081 19.2 8.0 21 5.1 0.1 5.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4609) Big_8 PF17961.1 PIK44786.1 - 0.0014 18.7 12.3 0.12 12.6 0.6 4.3 7 0 0 7 7 7 2 Bacterial Ig domain Omp28 PF11551.8 PIK44786.1 - 0.0018 18.2 1.5 2.2 8.1 0.1 3.1 2 0 0 2 2 2 2 Outer membrane protein Omp28 Band_7 PF01145.25 PIK44786.1 - 0.15 12.0 0.8 23 5.0 0.1 2.5 2 0 0 2 2 2 0 SPFH domain / Band 7 family Big_3_3 PF13750.6 PIK44786.1 - 0.32 10.6 24.6 9.2 5.9 0.3 7.6 2 2 6 8 8 8 0 Bacterial Ig-like domain (group 3) MBF2 PF15868.5 PIK44786.1 - 3.2 8.3 5.3 39 4.9 0.1 4.3 4 1 0 4 4 4 0 Transcription activator MBF2 HYR PF02494.16 PIK44787.1 - 4.2e-37 126.3 13.1 2.7e-16 59.7 4.9 3.0 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK44787.1 - 0.00076 19.6 0.5 0.38 10.9 0.3 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF5011) Big_3_3 PF13750.6 PIK44787.1 - 0.0081 15.8 4.1 0.045 13.4 1.1 2.7 2 1 1 3 3 3 1 Bacterial Ig-like domain (group 3) DOMON PF03351.17 PIK44787.1 - 0.02 15.1 0.4 0.73 10.0 0.2 2.2 2 0 0 2 2 2 0 DOMON domain Hce2 PF14856.6 PIK44787.1 - 0.033 14.5 2.4 1.1 9.6 0.5 3.0 2 1 1 3 3 3 0 Pathogen effector; putative necrosis-inducing factor ComGG PF14173.6 PIK44787.1 - 0.23 11.9 0.6 0.75 10.2 0.4 1.9 1 1 2 3 3 3 0 ComG operon protein 7 Cadherin_5 PF17892.1 PIK44787.1 - 0.32 11.0 9.7 0.37 10.8 1.1 2.9 3 0 0 3 3 3 0 Cadherin-like domain Big_9 PF17963.1 PIK44787.1 - 0.84 10.4 23.7 0.62 10.9 14.0 3.1 2 1 1 3 3 3 0 Bacterial Ig domain Pur_ac_phosph_N PF16656.5 PIK44787.1 - 0.87 10.2 6.6 1.4 9.5 4.3 2.0 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain DUF1522 PF07482.11 PIK44787.1 - 5.4 7.4 13.8 0.49 10.7 7.4 2.3 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1522) CCDC-167 PF15188.6 PIK44789.1 - 0.1 13.0 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 PRESAN PF09687.10 PIK44790.1 - 0.093 13.3 0.0 0.12 13.0 0.0 1.1 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Sel1 PF08238.12 PIK44791.1 - 1.4e-11 44.6 0.6 2.1e-08 34.6 0.1 2.6 2 0 0 2 2 2 2 Sel1 repeat LMBR1 PF04791.16 PIK44791.1 - 0.043 12.7 0.1 0.061 12.2 0.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Pyr_redox_3 PF13738.6 PIK44792.1 - 1.2e-06 28.1 1.3 0.00026 20.4 0.0 2.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK44792.1 - 5.6e-05 22.5 0.0 0.0018 17.5 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Imm47 PF15573.6 PIK44792.1 - 0.0082 15.7 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 Immunity protein 47 K_oxygenase PF13434.6 PIK44792.1 - 0.021 14.0 0.0 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NIBRIN_BRCT_II PF16508.5 PIK44793.1 - 8.4e-22 77.7 0.0 3e-21 76.0 0.0 2.0 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein Nbs1_C PF08599.10 PIK44793.1 - 5.7e-15 55.2 0.0 5.7e-15 55.2 0.0 2.0 2 0 0 2 2 2 1 DNA damage repair protein Nbs1 FHA PF00498.26 PIK44793.1 - 6.3e-11 42.5 0.1 1.6e-10 41.2 0.1 1.7 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 PIK44793.1 - 1.3e-07 31.9 0.1 0.00082 19.7 0.0 3.1 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 PIK44793.1 - 1.1e-06 28.4 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 PIK44793.1 - 8.1e-06 26.2 0.2 0.00044 20.6 0.0 3.0 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 PIK44793.1 - 0.00014 21.7 0.0 0.00034 20.5 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain Aa_trans PF01490.18 PIK44794.1 - 1e-49 169.4 19.9 1.4e-49 169.0 19.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF5554 PF17709.1 PIK44794.1 - 0.51 10.5 4.9 0.47 10.6 0.1 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5554) DUF2095 PF09868.9 PIK44795.1 - 0.00048 20.1 0.1 0.002 18.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2095) DED PF01335.21 PIK44795.1 - 0.071 13.4 1.8 0.17 12.2 0.1 2.4 2 0 0 2 2 2 0 Death effector domain Toprim_Crpt PF13342.6 PIK44795.1 - 0.53 10.3 4.3 53 3.9 0.0 3.5 3 0 0 3 3 3 0 C-terminal repeat of topoisomerase TIMP PF00965.17 PIK44796.1 - 1e-22 80.8 7.3 2.6e-22 79.5 7.3 1.6 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK44796.1 - 0.00022 21.0 0.1 0.017 14.9 0.0 2.4 2 0 0 2 2 2 2 UNC-6/NTR/C345C module Fer4_4 PF12800.7 PIK44796.1 - 0.75 10.5 5.3 1.5 9.5 3.5 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain DNA_methylase PF00145.17 PIK44797.1 - 2.6e-22 79.6 0.5 3.4e-22 79.3 0.5 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase SRCR PF00530.18 PIK44798.1 - 2.5e-79 262.2 11.5 1.5e-26 92.8 0.4 3.0 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK44798.1 - 2.9e-18 66.2 17.1 9.9e-06 26.0 0.9 3.7 3 2 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK44798.1 - 1.3e-09 38.6 0.0 0.2 12.2 0.0 3.6 3 0 0 3 3 3 3 Hepsin, SRCR domain SBP56 PF05694.11 PIK44798.1 - 1.1e-07 31.1 1.5 0.065 12.0 0.0 3.1 3 0 0 3 3 3 3 56kDa selenium binding protein (SBP56) YecR PF13992.6 PIK44798.1 - 2.5e-05 24.5 4.9 0.68 10.3 0.1 3.6 3 1 0 3 3 3 3 YecR-like lipoprotein GPS PF01825.21 PIK44798.1 - 0.073 13.6 27.5 1.1 9.9 3.1 3.7 3 0 0 3 3 3 0 GPCR proteolysis site, GPS, motif DUF4062 PF13271.6 PIK44799.1 - 3.9e-11 43.2 0.0 9.8e-11 41.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) AAA_22 PF13401.6 PIK44800.1 - 0.027 14.7 0.0 0.05 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain WSD PF15613.6 PIK44800.1 - 0.04 14.4 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif AAA_16 PF13191.6 PIK44800.1 - 0.087 13.2 0.0 0.2 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain zf-H2C2_2 PF13465.6 PIK44802.1 - 4.2e-21 74.4 23.2 5.5e-07 29.7 1.4 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK44802.1 - 7.1e-17 60.8 35.6 7.9e-05 22.9 2.0 4.9 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44802.1 - 1.6e-09 37.8 33.6 0.005 17.6 1.9 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK44802.1 - 5.1e-06 26.7 15.0 0.0039 17.5 5.2 2.6 1 1 1 2 2 2 2 C2H2-type zinc ribbon SET PF00856.28 PIK44802.1 - 1.1e-05 25.9 0.0 2.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 SET domain zf-met PF12874.7 PIK44802.1 - 0.00084 19.6 24.7 0.031 14.7 1.2 4.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK44802.1 - 0.0056 16.9 0.1 0.0056 16.9 0.1 4.4 5 0 0 5 5 4 1 Zinc-finger double-stranded RNA-binding BolA PF01722.18 PIK44802.1 - 0.012 15.9 0.5 1.3 9.4 0.1 3.0 1 1 1 2 2 2 0 BolA-like protein zf-C2H2_6 PF13912.6 PIK44802.1 - 0.03 14.3 29.5 0.25 11.4 2.2 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2HE PF16278.5 PIK44802.1 - 0.52 10.8 20.6 0.94 10.0 0.3 4.8 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 PIK44802.1 - 3.4 7.4 6.9 16 5.2 0.6 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 PIK44802.1 - 4.5 7.3 5.2 46 4.1 5.2 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 PIK44802.1 - 7.6 7.4 7.4 6.7 7.5 1.1 2.5 1 1 1 2 2 2 0 zinc-ribbon family Cep57_CLD PF14073.6 PIK44803.1 - 2.1e-34 119.1 26.2 2.5e-34 118.9 26.2 1.0 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 TMF_TATA_bd PF12325.8 PIK44803.1 - 0.0011 19.2 25.4 0.062 13.5 14.3 2.6 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding Spectrin PF00435.21 PIK44803.1 - 0.048 14.2 19.2 0.78 10.2 5.7 2.1 1 1 1 2 2 2 0 Spectrin repeat DUF1515 PF07439.11 PIK44803.1 - 0.061 13.4 4.1 0.065 13.3 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF4407 PF14362.6 PIK44803.1 - 0.095 12.0 16.4 0.12 11.7 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 PIK44803.1 - 0.24 10.9 16.2 0.31 10.5 16.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.11 PIK44803.1 - 0.26 11.5 26.4 0.54 10.5 14.6 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4140 PF13600.6 PIK44803.1 - 0.33 11.4 19.9 2.1 8.9 1.4 3.2 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Prefoldin_2 PF01920.20 PIK44803.1 - 0.72 9.8 20.2 0.13 12.2 3.4 3.0 2 1 0 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.11 PIK44803.1 - 0.82 10.1 9.2 5 7.6 0.1 3.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Fmp27_WPPW PF10359.9 PIK44803.1 - 0.89 8.3 15.6 1.4 7.7 15.6 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain APG6_N PF17675.1 PIK44803.1 - 1.2 9.6 24.9 1.5 9.3 6.8 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region LMBR1 PF04791.16 PIK44803.1 - 2.2 7.1 10.7 2.7 6.8 10.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Cep57_CLD_2 PF14197.6 PIK44803.1 - 2.7 8.2 24.3 0.62 10.2 3.4 3.2 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 ALMT PF11744.8 PIK44803.1 - 3.2 6.5 10.1 3.7 6.3 10.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1664 PF07889.12 PIK44803.1 - 5.6 7.0 9.5 4.2 7.4 3.1 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 PIK44803.1 - 5.7 7.0 20.2 4.6 7.3 1.7 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 PIK44803.1 - 7.7 6.6 9.1 27 4.8 7.3 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_CTD PF16326.5 PIK44803.1 - 7.8 6.8 19.1 2.5 8.4 8.6 3.1 2 2 0 2 2 2 0 ABC transporter C-terminal domain NYD-SP28_assoc PF14775.6 PIK44803.1 - 8.2 6.6 10.6 0.33 11.1 3.3 2.4 2 1 1 3 3 3 0 Sperm tail C-terminal domain Syntaxin-6_N PF09177.11 PIK44803.1 - 8.4 7.0 16.5 57 4.4 13.9 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.18 PIK44803.1 - 8.5 5.6 13.1 38 3.4 13.2 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein V_ATPase_I PF01496.19 PIK44803.1 - 9.6 4.0 14.3 12 3.7 14.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.25 PIK44804.1 - 1.4e-14 54.1 0.0 2.1e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44804.1 - 1.3e-07 31.2 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase K1 PF02960.14 PIK44804.1 - 0.23 11.6 0.3 0.56 10.3 0.3 1.6 1 0 0 1 1 1 0 K1 glycoprotein HAGH_C PF16123.5 PIK44805.1 - 1e-21 77.2 0.0 2e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 PIK44805.1 - 1.9e-11 44.4 1.1 2.2e-09 37.6 1.1 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK44805.1 - 7.6e-05 22.3 0.0 0.00018 21.1 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK44805.1 - 0.0027 17.6 0.0 0.04 13.8 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain HECT PF00632.25 PIK44806.1 - 5.7e-86 288.8 0.0 6.1e-48 163.9 0.0 2.3 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) HECW1_helix PF18436.1 PIK44806.1 - 3.9e-30 103.7 2.1 9e-30 102.6 1.1 2.2 2 0 0 2 2 2 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 WW PF00397.26 PIK44806.1 - 1.2e-08 34.9 0.1 3.5e-07 30.2 0.0 2.6 2 0 0 2 2 2 1 WW domain HECW_N PF16562.5 PIK44807.1 - 1.3e-44 150.8 0.0 3e-44 149.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 PIK44807.1 - 0.002 18.7 0.0 0.0062 17.1 0.0 1.9 2 0 0 2 2 2 1 SKICH domain Mfa_like_1 PF13149.6 PIK44807.1 - 0.094 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Fimbrillin-like Myosin_head PF00063.21 PIK44809.1 - 4.4e-209 696.1 11.9 2.5e-122 409.4 1.2 2.9 2 1 0 2 2 2 2 Myosin head (motor domain) Myosin_TH1 PF06017.13 PIK44809.1 - 4.6e-33 114.5 0.1 5.5e-27 94.7 0.0 2.4 2 0 0 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 PIK44809.1 - 0.0076 16.0 1.5 0.0076 16.0 1.5 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif Zeta_toxin PF06414.12 PIK44809.1 - 0.069 12.4 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 PIK44809.1 - 0.085 13.2 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 PIK44809.1 - 0.11 12.8 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain CDK5_activator PF03261.15 PIK44810.1 - 2.3e-107 359.7 13.6 2.9e-107 359.4 13.6 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein PCI PF01399.27 PIK44811.1 - 6.9e-19 68.3 0.4 1.2e-18 67.5 0.4 1.4 1 0 0 1 1 1 1 PCI domain RPN6_C_helix PF18503.1 PIK44811.1 - 1.4e-14 53.5 0.1 3.4e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain PEP-utilisers_N PF05524.13 PIK44811.1 - 0.13 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal SapB_2 PF03489.17 PIK44812.1 - 5.8e-199 643.7 173.7 2.3e-12 46.8 0.8 25.2 24 0 0 24 24 23 22 Saposin-like type B, region 2 SapB_1 PF05184.15 PIK44812.1 - 3.8e-159 515.7 167.0 4.6e-13 48.9 2.1 23.7 22 0 0 22 22 22 21 Saposin-like type B, region 1 SapA PF02199.15 PIK44812.1 - 6.7e-23 80.7 23.7 6.5e-13 48.7 4.9 5.1 3 0 0 3 3 2 2 Saposin A-type domain P22_AR_C PF10548.9 PIK44812.1 - 1.1e-11 44.7 2.6 6.7 7.0 0.0 8.6 9 0 0 9 9 9 2 P22AR C-terminal domain Importin_rep_3 PF18806.1 PIK44812.1 - 0.0017 18.3 0.0 12 6.0 0.0 6.7 8 0 0 8 8 7 1 Importin 13 repeat DUF5073 PF16817.5 PIK44812.1 - 0.0018 18.3 0.0 58 3.8 0.0 6.0 6 0 0 6 6 6 0 Domain of unknown function (DUF5073) TetR_C_20 PF17925.1 PIK44812.1 - 0.016 15.5 0.2 76 3.7 0.0 4.3 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain YdjO PF14169.6 PIK44812.1 - 0.032 14.0 16.9 3 7.6 0.5 6.2 6 0 0 6 6 6 0 Cold-inducible protein YdjO CF222 PF15661.5 PIK44812.1 - 0.059 12.3 0.0 9.2 5.0 0.0 3.6 5 0 0 5 5 5 0 C6orf222, uncharacterised family Histidinol_dh PF00815.20 PIK44812.1 - 0.27 10.2 0.7 68 2.3 0.0 3.7 3 1 1 4 4 4 0 Histidinol dehydrogenase MqsA_antitoxin PF15731.5 PIK44812.1 - 0.3 11.2 3.5 32 4.6 1.0 4.2 3 0 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DYW_deaminase PF14432.6 PIK44812.1 - 1.7 8.6 28.4 2.7 7.9 0.1 9.6 11 0 0 11 11 11 0 DYW family of nucleic acid deaminases zf-HIT PF04438.16 PIK44812.1 - 1.8 8.5 7.1 9.7 6.2 0.2 5.7 3 0 0 3 3 3 0 HIT zinc finger RPAP1_N PF08621.10 PIK44812.1 - 4.2 7.2 8.5 74 3.2 0.0 5.5 6 0 0 6 6 6 0 RPAP1-like, N-terminal Peptidase_M10 PF00413.24 PIK44813.1 - 2.2e-49 167.3 0.1 3.2e-49 166.8 0.1 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK44813.1 - 9.4e-17 60.7 11.1 3.5e-05 23.6 0.2 4.5 4 0 0 4 4 4 4 Hemopexin Metallopep PF12044.8 PIK44813.1 - 0.00056 18.6 0.2 0.00096 17.9 0.2 1.3 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 PIK44813.1 - 0.0013 17.8 0.2 0.0026 16.8 0.2 1.4 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 PIK44813.1 - 0.0038 17.7 0.2 0.0073 16.8 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 PIK44813.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Astacin PF01400.24 PIK44813.1 - 0.013 15.1 2.6 2.8 7.5 0.2 2.5 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) DUF4953 PF16313.5 PIK44813.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.6 PIK44813.1 - 0.27 11.3 2.1 0.32 11.1 0.1 2.0 2 1 0 2 2 2 0 Metallo-peptidase family M12 SCP2 PF02036.17 PIK44814.1 - 6.9e-18 65.0 0.0 1.3e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family Band_7 PF01145.25 PIK44814.1 - 8.2e-16 58.5 0.1 1.3e-15 57.9 0.1 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Alkyl_sulf_C PF14864.6 PIK44814.1 - 0.028 14.7 0.0 0.069 13.4 0.0 1.6 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal Sulfotransfer_2 PF03567.14 PIK44815.1 - 7.2e-10 39.2 11.5 8.1e-06 25.9 0.0 3.3 2 2 1 3 3 3 2 Sulfotransferase family DUF1776 PF08643.10 PIK44815.1 - 0.055 12.8 0.1 0.087 12.2 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DDHD PF02862.17 PIK44815.1 - 0.15 12.2 4.8 0.22 11.7 4.8 1.4 1 0 0 1 1 1 0 DDHD domain FeoB_Cyto PF17910.1 PIK44815.1 - 0.4 11.3 5.2 2.9 8.5 5.2 2.3 1 1 0 1 1 1 0 FeoB cytosolic helical domain Presenilin PF01080.17 PIK44815.1 - 0.44 9.3 10.2 0.54 9.0 10.2 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 PIK44815.1 - 0.48 9.4 12.3 0.63 9.0 12.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 PIK44815.1 - 0.69 9.9 5.8 0.92 9.5 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 PIK44815.1 - 0.69 8.9 6.7 0.98 8.4 6.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein NPAT_C PF15712.5 PIK44815.1 - 0.72 8.4 16.7 0.92 8.1 16.7 1.1 1 0 0 1 1 1 0 NPAT C terminus ALMT PF11744.8 PIK44815.1 - 0.95 8.2 8.0 1.1 8.0 8.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 PIK44815.1 - 0.97 7.7 13.0 1.2 7.4 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 PIK44815.1 - 1.2 9.3 17.2 1.8 8.7 17.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) GREB1 PF15782.5 PIK44815.1 - 1.2 6.2 8.5 1.4 6.0 8.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 PIK44815.1 - 1.7 6.7 10.0 2 6.4 10.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 PIK44815.1 - 4.9 6.9 18.7 7.4 6.3 18.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 PIK44815.1 - 5.9 6.0 7.4 7.6 5.6 7.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 PIK44815.1 - 6 4.7 9.6 7.6 4.3 9.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HMG_box PF00505.19 PIK44816.1 - 3.4e-17 62.6 6.7 2.4e-09 37.5 2.7 4.5 4 2 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK44816.1 - 3.6e-14 53.1 5.7 1.4e-08 35.2 1.4 4.1 3 1 1 4 4 4 2 HMG-box domain TraH_2 PF06871.11 PIK44816.1 - 0.18 11.5 4.5 0.081 12.6 2.0 1.6 1 1 1 2 2 2 0 TraH_2 Ferlin_C PF16165.5 PIK44816.1 - 0.19 11.6 0.2 0.19 11.6 0.2 2.4 2 0 0 2 2 2 0 Ferlin C-terminus AP3D1 PF06375.11 PIK44816.1 - 0.25 11.6 20.7 0.11 12.7 9.0 2.1 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 PPL5 PF18168.1 PIK44816.1 - 1.3 8.2 12.4 1.6 7.9 5.3 2.0 2 0 0 2 2 2 0 Prim-pol family 5 Glyco_tran_10_N PF17039.5 PIK44817.1 - 1.2e-13 51.4 0.2 1.6e-13 51.0 0.2 1.1 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Collagen_bind_2 PF12904.7 PIK44817.1 - 0.0049 16.8 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative collagen-binding domain of a collagenase Glyco_transf_10 PF00852.19 PIK44818.1 - 2.9e-30 105.3 0.1 3.3e-30 105.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_trans_1_2 PF13524.6 PIK44818.1 - 0.00026 21.3 0.0 0.00042 20.7 0.0 1.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 YfdX PF10938.8 PIK44818.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 YfdX protein SNF PF00209.18 PIK44819.1 - 3e-51 174.7 6.1 3.5e-51 174.5 6.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF2046 PF09755.9 PIK44820.1 - 5.7e-94 314.8 60.4 2.2e-91 306.3 60.4 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 PIK44820.1 - 1.4 9.1 47.0 0.041 14.1 26.1 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) zf-C2H2 PF00096.26 PIK44821.1 - 4.7e-14 52.0 19.2 8.9e-06 25.9 3.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK44821.1 - 1.5e-12 47.4 17.7 2.3e-07 30.9 0.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK44821.1 - 2.6e-12 46.5 18.9 5.4e-05 23.7 2.4 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK44821.1 - 1.3e-05 25.1 20.6 0.023 14.7 1.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 PIK44821.1 - 0.00032 21.0 12.5 0.002 18.5 1.7 3.0 3 0 0 3 3 2 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK44821.1 - 0.00054 20.0 4.4 0.37 11.0 0.7 2.5 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_jaz PF12171.8 PIK44821.1 - 0.0026 18.0 24.2 0.0039 17.4 0.2 4.2 5 0 0 5 5 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK44821.1 - 0.0029 17.5 4.5 7.9 6.5 0.1 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 PIK44821.1 - 0.006 17.0 6.7 0.006 17.0 6.7 3.4 1 1 2 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger Endonuclease_7 PF02945.15 PIK44821.1 - 0.0073 16.2 1.6 0.0073 16.2 1.6 2.2 1 1 1 2 2 2 1 Recombination endonuclease VII zf_ZIC PF18366.1 PIK44821.1 - 0.015 15.4 3.6 0.28 11.3 0.2 2.6 2 0 0 2 2 2 0 Zic proteins zinc finger domain C1_1 PF00130.22 PIK44821.1 - 0.016 15.1 9.3 1.1 9.1 0.3 3.2 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_3rep PF18868.1 PIK44821.1 - 0.028 15.1 2.8 0.028 15.1 2.8 2.9 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK44821.1 - 0.037 14.3 6.6 0.061 13.6 5.0 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon YppG PF14179.6 PIK44821.1 - 0.043 14.5 0.6 0.043 14.5 0.6 2.2 2 0 0 2 2 2 0 YppG-like protein ADK_lid PF05191.14 PIK44821.1 - 0.045 13.8 0.9 0.045 13.8 0.9 2.0 2 0 0 2 2 1 0 Adenylate kinase, active site lid zf-C2H2_2 PF12756.7 PIK44821.1 - 0.051 13.9 14.8 0.43 10.9 1.2 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-FCS PF06467.14 PIK44821.1 - 0.057 13.4 7.6 0.23 11.5 4.2 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-MYST PF17772.1 PIK44821.1 - 0.16 11.6 0.3 0.16 11.6 0.3 3.2 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2H2_9 PF16293.5 PIK44821.1 - 0.24 11.3 2.0 2.4 8.1 0.1 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-CCHC_2 PF13696.6 PIK44821.1 - 0.27 11.1 7.8 1.5 8.7 1.7 2.6 2 0 0 2 2 2 0 Zinc knuckle zinc_ribbon_9 PF14369.6 PIK44821.1 - 0.34 11.2 8.2 0.56 10.5 0.1 2.9 2 1 0 2 2 2 0 zinc-ribbon BolA PF01722.18 PIK44821.1 - 0.42 10.9 4.6 3.5 8.0 0.2 3.2 2 1 1 3 3 3 0 BolA-like protein zf-BED PF02892.15 PIK44821.1 - 0.55 10.3 14.1 0.088 12.9 2.7 3.3 1 1 2 3 3 3 0 BED zinc finger zf_UBZ PF18439.1 PIK44821.1 - 0.68 9.6 6.3 1.2 8.8 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 PIK44821.1 - 1.1 9.3 6.4 16 5.7 0.2 3.1 3 0 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_15 PF17032.5 PIK44821.1 - 1.3 9.8 8.0 1.8 9.4 4.4 2.3 1 1 1 2 2 2 0 zinc-ribbon family HHV6-IE PF03753.13 PIK44821.1 - 1.5 6.2 4.2 1.9 5.9 4.2 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein zinc-ribbons_6 PF07191.12 PIK44821.1 - 3.7 7.6 7.8 1.3e+02 2.7 7.5 2.9 1 1 1 2 2 2 0 zinc-ribbons zf-C2H2_11 PF16622.5 PIK44821.1 - 4 7.3 10.0 0.36 10.6 1.2 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 PIK44821.1 - 7.2 6.5 18.4 0.083 12.7 1.7 3.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK44822.1 - 3.2e-23 81.0 24.8 1.2e-09 38.1 1.7 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK44822.1 - 4.6e-07 29.9 26.8 0.00098 19.5 4.4 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44822.1 - 1.5e-05 25.5 20.3 0.026 15.3 0.9 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK44822.1 - 0.0047 17.2 8.0 0.079 13.3 0.2 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK44822.1 - 0.024 14.5 8.7 1.7 8.6 0.5 3.3 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC5 PF06221.13 PIK44822.1 - 0.025 14.6 7.7 8.5 6.5 2.8 3.2 1 1 2 3 3 3 0 Putative zinc finger motif, C2HC5-type zf-CHCC PF10276.9 PIK44822.1 - 0.064 13.3 8.4 0.26 11.4 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger domain zf-BED PF02892.15 PIK44822.1 - 0.066 13.2 0.7 0.066 13.2 0.7 3.2 2 1 1 3 3 3 0 BED zinc finger FYDLN_acid PF09538.10 PIK44822.1 - 0.083 13.6 7.6 4.6 8.0 2.6 2.8 1 1 2 3 3 3 0 Protein of unknown function (FYDLN_acid) FYVE PF01363.21 PIK44822.1 - 0.1 12.7 12.7 2.1 8.6 12.7 2.4 1 1 0 1 1 1 0 FYVE zinc finger DUF2072 PF09845.9 PIK44822.1 - 0.12 12.6 8.8 0.12 12.7 5.3 2.1 2 0 0 2 2 2 0 Zn-ribbon containing protein zf-C2H2_6 PF13912.6 PIK44822.1 - 0.15 12.1 16.1 0.42 10.7 2.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK44822.1 - 0.26 12.0 11.6 1.2 9.8 3.2 2.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf_C2H2_6 PF18450.1 PIK44822.1 - 0.31 10.8 7.3 1.7 8.4 0.1 3.0 3 0 0 3 3 3 0 Zinc Finger domain Zf_RING PF16744.5 PIK44822.1 - 0.58 10.3 8.3 5.2 7.3 0.5 3.1 1 1 2 3 3 3 0 KIAA1045 RING finger zf-met PF12874.7 PIK44822.1 - 0.73 10.3 7.9 1.1 9.7 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type C1_4 PF07975.12 PIK44822.1 - 0.82 10.0 0.1 0.82 10.0 0.1 2.9 2 1 1 3 3 3 0 TFIIH C1-like domain XPA_N PF01286.18 PIK44822.1 - 1.2 9.3 0.1 1.2 9.3 0.1 2.6 3 0 0 3 3 3 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 PIK44822.1 - 1.9 8.7 9.1 0.27 11.4 2.1 2.8 1 1 2 3 3 3 0 Zinc ribbon domain zf-AN1 PF01428.16 PIK44822.1 - 4.1 7.7 15.6 3.3 8.0 0.3 3.5 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2HC_2 PF13913.6 PIK44822.1 - 6.6 6.8 12.7 5.9 6.9 0.9 3.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DUF4674 PF15719.5 PIK44822.1 - 8.3 6.4 15.5 3.8 7.5 7.2 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4674) NOT2_3_5 PF04153.18 PIK44823.1 - 2.5e-10 40.5 0.4 7.8e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family DUF2095 PF09868.9 PIK44825.1 - 0.12 12.4 0.0 0.24 11.3 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) HECT PF00632.25 PIK44826.1 - 1.8e-05 24.4 0.6 0.00083 18.9 0.2 2.5 2 1 0 2 2 2 2 HECT-domain (ubiquitin-transferase) rve PF00665.26 PIK44828.1 - 9e-22 77.5 0.0 1.3e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK44828.1 - 8.6e-06 25.5 0.2 1.4e-05 24.8 0.2 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44828.1 - 0.00026 21.0 0.1 0.00049 20.1 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain DUF3703 PF12487.8 PIK44828.1 - 0.066 13.0 0.2 2.3 8.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3703) RT_RNaseH PF17917.1 PIK44829.1 - 1.3e-26 92.9 0.0 2.5e-26 92.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK44829.1 - 3.1e-26 91.3 0.0 6.2e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44829.1 - 2.4e-07 30.5 0.1 4.2e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 PIK44829.1 - 0.0016 17.9 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain DUF4201 PF13870.6 PIK44829.1 - 0.057 13.2 0.1 0.095 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) THAP PF05485.12 PIK44832.1 - 2.3e-11 44.5 2.6 4e-11 43.7 2.6 1.4 1 0 0 1 1 1 1 THAP domain SAM_2 PF07647.17 PIK44832.1 - 0.058 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2064 PF09837.9 PIK44834.1 - 0.02 14.7 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) BEN PF10523.9 PIK44835.1 - 0.00019 21.6 0.0 0.00041 20.5 0.0 1.5 1 0 0 1 1 1 1 BEN domain bZIP_1 PF00170.21 PIK44835.1 - 0.023 14.8 0.8 0.078 13.1 0.8 1.9 1 0 0 1 1 1 0 bZIP transcription factor Shugoshin_N PF07558.11 PIK44835.1 - 0.12 12.2 0.5 0.24 11.3 0.5 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region ZapB PF06005.12 PIK44835.1 - 1.3 9.5 4.8 4.1 7.9 4.8 1.9 1 1 0 1 1 1 0 Cell division protein ZapB RVT_1 PF00078.27 PIK44838.1 - 2.2e-22 79.7 0.0 1.6e-21 76.9 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44840.1 - 2.7e-30 104.3 0.0 4.1e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44840.1 - 5.9e-24 84.4 0.0 9.5e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK44840.1 - 8.9e-20 71.2 0.0 1.4e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) KDZ PF18758.1 PIK44841.1 - 4.8e-30 104.8 0.2 7.5e-30 104.2 0.2 1.2 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK44841.1 - 2.6e-14 53.3 0.1 7.5e-14 51.8 0.1 1.8 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC1 PF18802.1 PIK44841.1 - 4.2e-12 46.1 0.2 1.1e-11 44.8 0.2 1.7 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK44841.1 - 4.4e-05 23.3 2.2 8.2e-05 22.4 0.2 2.5 2 1 0 3 3 3 1 CxC3 like cysteine cluster associated with KDZ transposases Death PF00531.22 PIK44842.1 - 1.3e-10 41.3 0.3 2e-10 40.7 0.3 1.3 1 0 0 1 1 1 1 Death domain HAUS5 PF14817.6 PIK44842.1 - 0.042 12.6 0.1 0.053 12.3 0.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 LRR_4 PF12799.7 PIK44844.1 - 9.4e-33 111.7 45.8 1.8e-08 34.5 7.0 7.2 3 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44844.1 - 3.6e-21 75.4 25.1 5.1e-08 32.6 8.6 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 PIK44844.1 - 4.9e-17 61.4 38.3 1.3e-06 28.1 4.2 6.0 1 1 5 6 6 6 6 Leucine rich repeat LRR_6 PF13516.6 PIK44844.1 - 0.00011 22.0 20.1 0.36 11.0 0.0 7.1 8 0 0 8 8 8 3 Leucine Rich repeat Phage_rep_org_N PF09681.10 PIK44844.1 - 0.011 15.6 6.6 3.6 7.5 0.2 3.5 1 1 2 3 3 3 0 N-terminal phage replisome organiser (Phage_rep_org_N) Ribosomal_L50 PF10501.9 PIK44844.1 - 0.02 15.1 0.4 5.4 7.2 0.1 2.9 1 1 1 3 3 3 0 Ribosomal subunit 39S MannoseP_isomer PF01050.18 PIK44844.1 - 0.067 13.1 0.1 0.21 11.5 0.0 1.9 1 1 0 1 1 1 0 Mannose-6-phosphate isomerase Orthopox_F6 PF06601.12 PIK44844.1 - 1.1 9.5 5.2 0.54 10.4 1.9 2.3 2 1 0 2 2 2 0 Orthopoxvirus F6 protein LRR_1 PF00560.33 PIK44844.1 - 1.1 10.0 30.0 5.3 8.0 0.2 8.8 9 1 0 9 9 9 0 Leucine Rich Repeat GMP_synt_C PF00958.22 PIK44845.1 - 6.9e-18 64.5 0.0 1.6e-11 44.1 0.0 2.6 2 0 0 2 2 2 2 GMP synthase C terminal domain NPV_P10 PF05531.12 PIK44845.1 - 0.087 13.3 0.1 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein GATase PF00117.28 PIK44846.1 - 1.5e-36 126.0 0.0 1.8e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 PIK44846.1 - 3.6e-13 49.8 0.0 8.6e-13 48.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 RVT_1 PF00078.27 PIK44847.1 - 1.5e-07 31.1 0.0 2.2e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mt_ATP_synt PF15704.5 PIK44847.1 - 0.051 13.5 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit gag-asp_proteas PF13975.6 PIK44848.1 - 2.1e-12 47.4 1.4 3.1e-10 40.5 0.1 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK44848.1 - 5.7e-11 42.9 1.4 7.7e-08 32.9 0.3 2.5 2 0 0 2 2 2 2 Aspartyl protease PNMA PF14893.6 PIK44848.1 - 0.0032 16.9 0.2 0.0053 16.2 0.2 1.3 1 0 0 1 1 1 1 PNMA Asp_protease PF09668.10 PIK44848.1 - 0.006 16.4 0.0 0.027 14.3 0.0 2.0 1 1 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK44848.1 - 0.0082 16.4 0.0 0.026 14.8 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 PIK44848.1 - 0.082 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) rve PF00665.26 PIK44849.1 - 8e-22 77.7 0.0 1.3e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44849.1 - 3.5e-10 39.8 0.6 3.5e-10 39.8 0.6 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44849.1 - 0.0075 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF5332 PF17266.2 PIK44849.1 - 0.075 12.7 0.0 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5332) RVT_1 PF00078.27 PIK44850.1 - 1.6e-11 44.2 0.0 2.5e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RPE65 PF03055.15 PIK44851.1 - 1.7e-121 406.6 0.0 2e-121 406.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein RPE65 PF03055.15 PIK44852.1 - 6.1e-77 259.8 0.1 1.7e-37 129.7 0.2 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein DUF3195 PF11424.8 PIK44852.1 - 0.15 12.1 0.2 0.73 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3195) Transglut_core PF01841.19 PIK44854.1 - 0.014 15.9 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF2299 PF10061.9 PIK44854.1 - 0.11 12.2 2.2 0.3 10.8 0.7 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2299) SNARE PF05739.19 PIK44854.1 - 1.1 9.3 3.8 3.4 7.8 0.4 2.6 2 0 0 2 2 2 0 SNARE domain RVT_1 PF00078.27 PIK44855.1 - 9.9e-34 116.8 0.0 1.3e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3449 PF11931.8 PIK44856.1 - 1.3e-76 256.6 0.6 1.3e-76 256.6 0.6 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3449) Telomere_Sde2_2 PF13297.6 PIK44856.1 - 5.1e-26 90.1 0.9 5.1e-26 90.1 0.9 2.0 2 0 0 2 2 2 1 Telomere stability C-terminal SF3A3 PF16837.5 PIK44856.1 - 4.5e-23 81.5 2.9 1.1e-22 80.3 2.9 1.7 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 PIK44856.1 - 2.3e-14 52.9 0.3 5.4e-14 51.8 0.3 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_4 PF13894.6 PIK44856.1 - 0.12 13.3 0.1 0.36 11.8 0.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.7 PIK44856.1 - 0.15 12.5 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Trypsin PF00089.26 PIK44857.1 - 1.2e-57 195.3 0.1 2.9e-56 190.8 0.1 2.1 1 1 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK44857.1 - 1.8e-06 28.3 0.0 3.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CUB PF00431.20 PIK44857.1 - 7.3e-06 26.3 0.0 1.7e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 CUB domain Trypsin_2 PF13365.6 PIK44857.1 - 1.6e-05 25.8 0.1 6.5e-05 23.9 0.1 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Fz PF01392.22 PIK44857.1 - 0.00017 22.1 5.5 0.00035 21.2 4.8 1.9 1 1 0 1 1 1 1 Fz domain Glypican PF01153.19 PIK44857.1 - 0.02 13.8 3.1 0.027 13.3 3.1 1.1 1 0 0 1 1 1 0 Glypican Trypsin PF00089.26 PIK44858.1 - 1.8e-64 217.6 0.0 2.4e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK44858.1 - 5.1e-08 33.3 0.0 8.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK44858.1 - 1.9e-06 28.8 0.0 3.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ldl_recept_a PF00057.18 PIK44859.1 - 2.9e-35 120.2 60.7 7.4e-10 38.9 13.2 4.1 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A DUF1629 PF07791.11 PIK44859.1 - 0.00053 20.1 0.5 2.7 8.1 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1629) SpuA_C PF18033.1 PIK44859.1 - 0.018 15.1 2.3 4.5 7.4 0.1 2.6 2 0 0 2 2 2 0 SpuA C-terminal Cys_rich_CWC PF14375.6 PIK44859.1 - 0.024 15.0 6.7 1.7 9.1 0.1 3.4 2 0 0 2 2 2 0 Cysteine-rich CWC DUF1307 PF06998.11 PIK44859.1 - 0.046 13.7 0.2 59 3.7 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1307) Colicin_K PF17500.2 PIK44859.1 - 0.2 12.3 0.3 43 4.8 0.0 2.7 2 1 1 3 3 3 0 Colicin-K Eaf7 PF07904.13 PIK44859.1 - 0.48 10.8 7.3 36 4.8 0.1 4.0 2 2 2 4 4 4 0 Chromatin modification-related protein EAF7 Toxin_27 PF08099.11 PIK44859.1 - 6.6 6.9 9.6 13 6.0 0.3 3.3 3 0 0 3 3 3 0 Scorpion calcine family Ribonuc_2-5A PF06479.12 PIK44860.1 - 0.007 16.5 1.5 0.014 15.6 1.5 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A CheR_N PF03705.15 PIK44860.1 - 0.035 13.8 0.1 0.07 12.9 0.1 1.5 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain T4-Gluco-transf PF09198.10 PIK44860.1 - 0.044 13.4 0.2 0.12 12.0 0.2 1.6 1 0 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase RNase_Zc3h12a PF11977.8 PIK44861.1 - 4.8e-25 88.2 0.0 7.4e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Regnase_1_C PF18561.1 PIK44861.1 - 4.6e-05 23.1 0.1 0.0001 22.0 0.1 1.5 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain zf-CCCH_4 PF18044.1 PIK44861.1 - 0.00097 18.9 5.3 0.0017 18.1 5.3 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 PIK44861.1 - 0.0068 16.3 4.9 0.074 13.0 1.6 2.4 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK44861.1 - 0.039 14.0 5.5 0.16 12.1 2.4 2.3 1 1 1 2 2 2 0 Zinc finger domain zf-CCCH_2 PF14608.6 PIK44861.1 - 0.16 12.5 4.6 0.32 11.5 4.6 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Ribosomal_S9 PF00380.19 PIK44862.1 - 4.1e-23 82.2 0.7 1.8e-22 80.1 0.7 2.0 1 1 0 1 1 1 1 Ribosomal protein S9/S16 SDF PF00375.18 PIK44863.1 - 4.1e-66 223.6 7.2 4.7e-66 223.4 7.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family GDC-P PF02347.16 PIK44864.1 - 9e-122 407.0 0.1 3.9e-121 404.9 0.1 1.7 1 1 0 1 1 1 1 Glycine cleavage system P-protein GDC-P PF02347.16 PIK44865.1 - 1.8e-42 145.7 0.0 1e-26 93.8 0.0 2.9 3 0 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 PIK44865.1 - 6.5e-05 22.3 0.1 0.00016 21.1 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 PIK44865.1 - 0.0002 20.5 0.0 0.00034 19.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V zf-C2H2_4 PF13894.6 PIK44866.1 - 9.6e-11 41.6 39.8 0.0059 17.3 3.2 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger PRP21_like_P PF12230.8 PIK44866.1 - 0.00042 20.3 7.7 0.0048 16.8 0.1 2.2 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein zf-C2H2 PF00096.26 PIK44866.1 - 0.00091 19.6 42.8 0.024 15.1 4.6 5.6 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-BED PF02892.15 PIK44866.1 - 0.0012 18.9 1.9 0.0012 18.9 1.9 5.4 3 2 2 5 5 5 1 BED zinc finger zf-C2H2_6 PF13912.6 PIK44866.1 - 0.014 15.3 3.7 0.014 15.3 3.7 6.3 7 0 0 7 7 7 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK44866.1 - 0.06 13.8 38.2 0.13 12.7 1.1 6.8 5 2 1 6 6 6 0 Zinc-finger double domain Actin_micro PF17003.5 PIK44866.1 - 0.26 10.4 17.9 0.053 12.7 7.2 3.0 1 1 0 2 2 2 0 Putative actin-like family Zn-C2H2_12 PF18112.1 PIK44866.1 - 0.27 11.7 12.6 0.21 12.1 0.6 4.2 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 PIK44866.1 - 0.89 9.9 33.2 0.086 13.1 2.0 4.1 3 1 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding FYVE PF01363.21 PIK44866.1 - 1.9 8.7 34.1 0.48 10.6 3.9 3.8 1 1 2 3 3 3 0 FYVE zinc finger C1_4 PF07975.12 PIK44866.1 - 5.3 7.4 22.6 3 8.1 4.3 3.5 2 1 1 3 3 3 0 TFIIH C1-like domain GAGA PF09237.11 PIK44866.1 - 6.2 6.7 13.5 12 5.7 0.6 4.0 2 2 2 4 4 4 0 GAGA factor Elf1 PF05129.13 PIK44866.1 - 6.2 6.9 21.6 10 6.3 7.3 3.8 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like zf-C2H2_jaz PF12171.8 PIK44866.1 - 7.1 7.0 21.6 16 6.0 0.3 5.0 5 0 0 5 5 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK44866.1 - 8.8 6.9 35.3 0.6 10.6 0.3 6.0 6 1 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK44867.1 - 3.1e-10 39.9 24.6 0.0046 17.3 0.7 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44867.1 - 2e-09 37.5 21.5 0.056 14.3 0.5 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-Di19 PF05605.12 PIK44867.1 - 0.0087 16.3 0.6 0.0087 16.3 0.6 3.1 2 1 0 2 2 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK44867.1 - 0.022 15.2 24.4 0.88 10.1 0.6 4.9 5 0 0 5 5 4 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 PIK44867.1 - 0.1 13.3 0.5 0.1 13.3 0.5 5.7 3 2 3 6 6 6 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 PIK44867.1 - 0.16 11.9 9.0 0.69 9.9 0.3 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 PIK44867.1 - 0.36 11.6 8.5 2.8 8.8 1.1 2.6 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_6 PF13912.6 PIK44867.1 - 0.4 10.8 16.1 7 6.8 0.5 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger vWF_A PF12450.8 PIK44867.1 - 0.52 10.3 5.1 17 5.4 0.1 3.1 1 1 3 4 4 4 0 von Willebrand factor HalOD2 PF18547.1 PIK44867.1 - 0.57 10.1 2.6 2.1 8.3 0.1 2.6 3 0 0 3 3 2 0 Halobacterial output domain 2 zf-U1 PF06220.12 PIK44867.1 - 0.62 9.9 7.1 0.15 11.8 0.3 2.6 2 0 0 2 2 2 0 U1 zinc finger DZR PF12773.7 PIK44867.1 - 0.86 9.7 9.4 2.3e+02 1.9 9.4 2.7 1 1 0 1 1 1 0 Double zinc ribbon zf-met PF12874.7 PIK44867.1 - 0.93 10.0 0.1 0.93 10.0 0.1 3.0 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf_C2H2_6 PF18450.1 PIK44867.1 - 1.4 8.7 4.5 16 5.3 0.1 3.2 3 0 0 3 3 3 0 Zinc Finger domain zf_UBZ PF18439.1 PIK44867.1 - 4.8 6.9 10.5 18 5.1 0.0 3.8 4 0 0 4 4 3 0 Ubiquitin-Binding Zinc Finger Catalase-rel PF06628.12 PIK44867.1 - 5.3 7.3 6.7 47 4.3 0.1 3.5 3 1 1 4 4 3 0 Catalase-related immune-responsive zf-ribbon_3 PF13248.6 PIK44867.1 - 6.7 6.3 10.1 26 4.4 0.0 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-RRN7 PF11781.8 PIK44867.1 - 7.9 6.3 7.6 2.2 8.0 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2H2 PF00096.26 PIK44868.1 - 2.9e-21 74.6 56.0 0.0059 17.0 1.5 8.8 8 1 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK44868.1 - 9.1e-18 63.4 53.5 0.0014 19.3 0.5 8.6 8 0 0 8 8 8 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK44868.1 - 5.8e-15 55.0 48.6 0.0014 19.0 3.3 9.5 9 1 0 9 9 9 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK44868.1 - 0.0061 16.5 0.2 0.0061 16.5 0.2 9.0 9 1 0 9 9 8 3 C2H2-type zinc finger zf-met PF12874.7 PIK44868.1 - 0.0098 16.3 32.6 1.6 9.2 0.6 7.6 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-TRAF PF02176.18 PIK44868.1 - 0.012 16.3 1.7 0.012 16.3 1.7 4.3 4 1 1 5 5 4 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.8 PIK44868.1 - 0.012 15.9 40.7 0.092 13.1 0.8 8.1 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK44868.1 - 0.012 15.9 26.5 0.42 10.9 5.7 4.2 2 2 2 4 4 4 0 C2H2-type zinc ribbon zf_C2H2_13 PF18508.1 PIK44868.1 - 0.014 15.0 6.9 1.3 8.7 0.2 3.8 3 0 0 3 3 3 0 Zinc finger domain zf-Di19 PF05605.12 PIK44868.1 - 0.21 11.9 36.1 0.93 9.8 1.3 6.1 5 1 0 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf_ZIC PF18366.1 PIK44868.1 - 0.22 11.6 3.1 14 5.9 0.5 3.5 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_11 PF16622.5 PIK44868.1 - 1.6 8.5 15.9 1.8 8.4 2.4 4.4 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 PIK44868.1 - 4 7.8 36.8 4.1 7.8 2.0 6.5 2 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 PIK44869.1 - 3.5e-25 87.3 57.9 7.5e-08 32.5 0.3 10.0 10 0 0 10 10 10 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK44869.1 - 1.9e-24 84.2 59.9 0.00019 22.0 1.6 9.4 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK44869.1 - 1.1e-20 72.8 63.6 0.00017 21.9 0.6 9.7 8 1 1 9 9 9 8 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK44869.1 - 0.00044 20.5 37.0 0.014 15.7 4.2 6.0 2 2 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK44869.1 - 0.00064 19.7 1.1 0.00064 19.7 1.1 9.6 10 0 0 10 10 10 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK44869.1 - 0.0063 16.8 0.4 0.0063 16.8 0.4 8.9 9 2 1 10 10 9 1 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 PIK44869.1 - 0.01 15.6 8.1 1.8 8.4 0.0 4.4 3 1 1 4 4 4 0 GAGA factor zf-met PF12874.7 PIK44869.1 - 0.025 15.0 34.5 0.082 13.3 0.9 7.2 8 0 0 8 8 7 0 Zinc-finger of C2H2 type HypA PF01155.19 PIK44869.1 - 0.059 13.4 25.8 0.15 12.1 0.6 5.2 2 2 2 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PyrI_C PF02748.15 PIK44869.1 - 0.15 12.0 0.3 0.15 12.0 0.3 6.3 5 2 3 8 8 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 PIK44869.1 - 0.16 12.8 28.7 4.5 8.1 0.8 5.3 2 1 3 5 5 5 0 zinc-ribbon family zf_C2H2_ZHX PF18387.1 PIK44869.1 - 0.9 9.2 0.0 0.9 9.2 0.0 4.3 4 1 1 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain C1_1 PF00130.22 PIK44869.1 - 1.5 8.7 35.2 0.45 10.4 1.2 5.9 5 1 1 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rad50_zn_hook PF04423.14 PIK44869.1 - 2.6 7.9 11.4 4 7.3 0.1 4.2 4 0 0 4 4 4 0 Rad50 zinc hook motif DUF2310 PF10071.9 PIK44869.1 - 4.5 6.5 9.7 2.5 7.3 0.9 3.4 3 0 0 3 3 3 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) zf-C2H2_9 PF16293.5 PIK44869.1 - 8.2 6.4 8.8 24 4.9 0.1 4.4 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf_UBZ PF18439.1 PIK44869.1 - 8.8 6.0 26.7 17 5.1 0.1 7.4 7 0 0 7 7 7 0 Ubiquitin-Binding Zinc Finger DUF21 PF01595.20 PIK44870.1 - 0.01 15.5 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain PAF-AH_p_II PF03403.13 PIK44870.1 - 0.24 9.9 3.0 0.34 9.4 3.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II HMG_box_2 PF09011.10 PIK44870.1 - 0.39 11.3 7.6 0.16 12.6 4.9 1.7 2 0 0 2 2 2 0 HMG-box domain ATP-synt_C PF00137.21 PIK44871.1 - 4.8e-13 49.2 14.8 4.8e-13 49.2 14.8 3.4 3 1 1 4 4 4 2 ATP synthase subunit C DUF5433 PF17498.2 PIK44871.1 - 0.032 14.4 0.7 0.082 13.1 0.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5433) Zn_Tnp_IS91 PF14319.6 PIK44872.1 - 0.014 15.4 5.0 0.031 14.3 0.2 3.8 5 0 0 5 5 5 0 Transposase zinc-binding domain zf-TFIIB PF13453.6 PIK44872.1 - 0.032 13.5 0.6 0.21 11.0 0.6 2.3 1 1 0 1 1 1 0 Transcription factor zinc-finger GA-like PF17573.2 PIK44872.1 - 0.12 12.4 2.0 0.13 12.3 0.2 2.0 2 0 0 2 2 2 0 GA-like domain SSF PF00474.17 PIK44874.1 - 1e-20 74.0 11.7 1.5e-20 73.4 11.7 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family RGP PF03214.13 PIK44874.1 - 0.048 12.8 0.1 0.061 12.5 0.1 1.1 1 0 0 1 1 1 0 Reversibly glycosylated polypeptide SSF PF00474.17 PIK44875.1 - 9.7e-17 60.9 6.5 1.1e-16 60.7 6.5 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK44876.1 - 4.8e-43 147.6 25.2 2.2e-42 145.4 25.2 2.0 1 1 0 1 1 1 1 Sodium:solute symporter family DUF4083 PF13314.6 PIK44876.1 - 0.054 13.4 0.7 0.054 13.4 0.7 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4083) SSF PF00474.17 PIK44877.1 - 1.1e-28 100.2 18.5 2.1e-28 99.3 18.5 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family RTC PF01137.21 PIK44878.1 - 3.4e-55 186.6 0.0 4e-54 183.2 0.0 2.0 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 PIK44878.1 - 1e-26 93.5 0.2 1.8e-26 92.6 0.2 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain 2-oxoacid_dh PF00198.23 PIK44879.1 - 5.8e-76 255.0 0.0 8.7e-76 254.4 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 PIK44879.1 - 9.8e-19 67.0 0.5 1.8e-18 66.1 0.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 PIK44879.1 - 4e-14 52.7 1.1 6.9e-14 51.9 0.2 1.9 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 PIK44879.1 - 0.0042 16.9 2.4 1.7 8.5 0.1 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like MCPVI PF02993.14 PIK44879.1 - 0.16 11.8 3.3 0.5 10.2 0.3 2.2 2 0 0 2 2 2 0 Minor capsid protein VI TPR_2 PF07719.17 PIK44880.1 - 1.2e-08 34.4 0.0 0.032 14.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK44880.1 - 1.1e-05 25.0 0.0 0.2 11.5 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK44880.1 - 0.0022 18.2 0.0 0.6 10.6 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK44880.1 - 0.0034 17.5 0.0 0.13 12.6 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK44880.1 - 0.0039 17.8 0.1 0.5 11.1 0.0 2.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK44880.1 - 0.0046 17.4 0.2 0.97 10.0 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK44880.1 - 0.005 16.5 0.0 0.023 14.4 0.0 2.1 2 1 1 3 3 3 1 TPR repeat TPR_14 PF13428.6 PIK44880.1 - 0.0068 17.1 0.4 0.43 11.5 0.0 2.6 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK44880.1 - 0.02 15.0 0.0 0.069 13.2 0.0 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) BTAD PF03704.17 PIK44880.1 - 0.083 13.3 1.2 0.34 11.3 1.2 2.0 1 1 0 1 1 1 0 Bacterial transcriptional activator domain PIF1 PF05970.14 PIK44881.1 - 2.4e-66 224.4 1.2 3e-64 217.5 1.2 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 PIK44881.1 - 1.9e-20 73.4 0.0 4.1e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK44881.1 - 3.9e-09 37.0 0.0 1.8e-08 34.9 0.0 2.1 2 1 0 2 2 1 1 AAA domain Herpes_Helicase PF02689.14 PIK44881.1 - 1.3e-05 23.4 0.1 0.00027 19.0 0.0 2.1 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 PIK44881.1 - 0.00017 21.8 0.0 0.00065 20.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK44881.1 - 0.0017 17.9 0.0 0.004 16.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region UvrD_C_2 PF13538.6 PIK44881.1 - 0.0019 18.0 0.0 0.0053 16.5 0.0 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Mg_chelatase PF01078.21 PIK44881.1 - 0.0025 17.2 0.1 0.009 15.4 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 PIK44881.1 - 0.0086 15.5 0.1 0.018 14.5 0.1 1.5 1 0 0 1 1 1 1 PhoH-like protein RsgA_GTPase PF03193.16 PIK44881.1 - 0.011 15.7 0.2 0.053 13.4 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 PIK44881.1 - 0.014 15.8 0.1 0.04 14.3 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK44881.1 - 0.025 14.9 0.0 0.054 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK44881.1 - 0.044 14.3 0.1 0.14 12.6 0.1 1.8 1 1 0 1 1 1 0 ABC transporter DEAD PF00270.29 PIK44881.1 - 0.05 13.4 0.1 4.6 7.0 0.1 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.6 PIK44881.1 - 0.056 13.2 2.8 1.2 8.9 0.2 3.0 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 PIK44881.1 - 0.11 12.2 0.0 0.33 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 PIK44881.1 - 0.13 11.4 0.0 0.36 10.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.6 PIK44881.1 - 0.19 11.5 0.8 0.49 10.2 0.3 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain RVT_1 PF00078.27 PIK44882.1 - 6.4e-46 156.6 0.1 9.9e-46 156.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YidD PF01809.18 PIK44882.1 - 0.016 15.1 0.3 0.041 13.8 0.3 1.7 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor NDUF_B6 PF09782.9 PIK44883.1 - 0.00057 20.1 0.3 0.00057 20.1 0.3 1.7 1 1 0 2 2 2 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Phage_Gp23 PF10669.9 PIK44883.1 - 0.14 12.5 1.7 0.17 12.2 1.7 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Lipase PF00151.19 PIK44884.1 - 3.3e-90 302.8 0.0 3.9e-90 302.6 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_1 PF00561.20 PIK44884.1 - 0.0029 17.3 0.9 0.011 15.4 0.9 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK44884.1 - 0.0033 16.7 0.3 0.0054 16.0 0.3 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK44884.1 - 0.0077 16.8 0.7 0.015 15.9 0.7 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family HCBP_related PF06594.11 PIK44884.1 - 0.054 13.4 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain CBFD_NFYB_HMF PF00808.23 PIK44885.1 - 4.5e-16 58.9 0.0 7.9e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK44885.1 - 7.1e-10 39.3 0.4 9.5e-10 38.9 0.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 fn3 PF00041.21 PIK44886.1 - 2e-14 53.7 0.1 3.3e-13 49.8 0.0 2.5 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK44886.1 - 0.0011 19.5 0.1 0.0027 18.2 0.1 1.7 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK44886.1 - 0.076 13.2 0.0 0.28 11.4 0.0 1.9 1 1 0 1 1 1 0 Fibronectin type III domain fn3 PF00041.21 PIK44887.1 - 3.4e-32 110.6 6.5 1.8e-13 50.7 0.1 3.7 4 0 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK44887.1 - 7.8e-11 42.4 2.2 0.00028 21.4 0.0 3.9 2 1 1 3 3 3 3 Purple acid Phosphatase, N-terminal domain SusE PF14292.6 PIK44887.1 - 0.00035 20.8 0.4 0.41 10.9 0.0 3.3 3 1 0 3 3 3 2 SusE outer membrane protein fn3_2 PF16893.5 PIK44887.1 - 0.001 19.2 1.0 0.061 13.5 0.7 3.2 2 1 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 PIK44887.1 - 0.0054 17.0 2.8 4.3 7.7 0.2 3.9 3 1 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III Reeler PF02014.16 PIK44887.1 - 0.026 15.3 2.0 11 6.7 0.0 4.4 3 2 1 5 5 5 0 Reeler domain Big_4 PF07532.11 PIK44887.1 - 0.71 9.7 5.0 3 7.6 0.8 3.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 4) Y_phosphatase PF00102.27 PIK44888.1 - 1.5e-66 224.3 0.2 2.5e-66 223.6 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK44888.1 - 4.1e-05 23.4 0.0 0.00012 21.9 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain TMEM154 PF15102.6 PIK44888.1 - 0.0063 16.4 0.1 0.016 15.1 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family Y_phosphatase3 PF13350.6 PIK44888.1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK44888.1 - 0.014 15.5 0.0 0.033 14.3 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF4006 PF13179.6 PIK44888.1 - 0.043 13.7 0.6 0.22 11.5 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Mycobact_memb PF05423.13 PIK44888.1 - 0.052 13.5 1.2 1.9 8.4 0.2 2.2 2 0 0 2 2 2 0 Mycobacterium membrane protein EphA2_TM PF14575.6 PIK44888.1 - 0.062 14.2 0.0 0.17 12.8 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.5 PIK44888.1 - 0.27 11.1 2.1 0.28 11.0 0.4 1.9 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator DUF2970 PF11174.8 PIK44888.1 - 0.99 9.3 9.4 2.8 7.8 7.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) SARAF PF06682.12 PIK44890.1 - 6.5e-68 229.8 0.5 8.5e-68 229.4 0.5 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Chordopox_A13L PF05961.11 PIK44890.1 - 0.068 13.4 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 Chordopoxvirus A13L protein RVT_1 PF00078.27 PIK44891.1 - 1.9e-26 93.0 0.0 3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK44891.1 - 1.2e-07 31.7 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK44892.1 - 8.5e-23 80.8 0.0 3.2e-22 79.0 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK44892.1 - 6e-15 55.1 3.1 3.7e-14 52.5 1.5 2.6 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK44892.1 - 5e-05 23.0 0.6 0.00013 21.7 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK44892.1 - 0.092 13.0 1.6 0.093 13.0 0.1 1.7 2 0 0 2 2 2 0 DDE domain SSF PF00474.17 PIK44893.1 - 4e-26 91.8 14.6 1.5e-25 89.9 14.6 1.7 1 1 0 1 1 1 1 Sodium:solute symporter family Integrase_H2C2 PF17921.1 PIK44894.1 - 7.2e-24 83.7 0.0 1.5e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK44894.1 - 1.5e-15 57.3 0.0 2.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK44894.1 - 8.2e-08 32.5 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK44894.1 - 2.5e-05 24.4 0.0 5.6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger WD40 PF00400.32 PIK44895.1 - 2e-38 129.7 7.1 3.1e-06 27.8 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44895.1 - 1.5e-17 63.7 0.2 6.3e-05 23.2 0.0 5.6 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK44895.1 - 1.6e-14 53.6 0.6 0.0011 18.0 0.1 3.9 3 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH_TPL PF17814.1 PIK44895.1 - 1.7e-12 46.8 0.2 3.6e-12 45.7 0.2 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain Nup160 PF11715.8 PIK44895.1 - 1.3e-08 34.0 0.2 0.029 13.0 0.2 3.8 2 1 0 4 4 4 3 Nucleoporin Nup120/160 Hira PF07569.11 PIK44895.1 - 0.011 15.4 2.9 3.6 7.2 0.1 4.3 5 0 0 5 5 5 0 TUP1-like enhancer of split PD40 PF07676.12 PIK44895.1 - 0.02 14.8 0.0 1 9.4 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RT_RNaseH_2 PF17919.1 PIK44896.1 - 9.8e-27 92.9 0.0 2.3e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK44896.1 - 5.8e-21 74.8 0.0 1.2e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK44896.1 - 1.7e-16 60.5 0.0 3.1e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK44896.1 - 4e-15 55.9 0.0 9e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK44896.1 - 6.4e-15 55.0 0.1 6.4e-15 55.0 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK44896.1 - 0.13 12.5 0.1 0.34 11.2 0.1 1.8 1 0 0 1 1 1 0 H2C2 zinc finger Form_Nir_trans PF01226.17 PIK44897.1 - 0.0029 17.0 0.9 0.0038 16.6 0.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter DUF973 PF06157.11 PIK44897.1 - 0.0062 15.6 0.7 0.0081 15.3 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF973) DUF996 PF06195.13 PIK44897.1 - 0.01 16.1 3.3 0.016 15.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF996) DUF3742 PF12553.8 PIK44897.1 - 0.019 15.1 0.3 0.035 14.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) SUR7 PF06687.12 PIK44897.1 - 0.021 14.5 2.6 0.031 13.9 2.6 1.3 1 0 0 1 1 1 0 SUR7/PalI family Frag1 PF10277.9 PIK44897.1 - 0.037 13.5 4.9 0.055 13.0 4.9 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Orf78 PF06024.12 PIK44897.1 - 0.31 11.3 1.3 1.2 9.4 0.9 2.0 2 0 0 2 2 2 0 Orf78 (ac78) COX6C PF02937.15 PIK44897.1 - 0.35 11.0 1.4 0.63 10.2 0.5 1.8 1 1 1 2 2 2 0 Cytochrome c oxidase subunit VIc DUF1218 PF06749.12 PIK44897.1 - 0.66 10.5 8.3 0.4 11.2 4.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) DUF4190 PF13828.6 PIK44897.1 - 1.6 8.6 11.3 4.2 7.2 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) UPF0258 PF06789.12 PIK44897.1 - 1.8 8.7 4.1 4.1 7.5 4.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) TMEM132D_C PF15706.5 PIK44897.1 - 6 6.7 6.6 7.9 6.3 1.3 2.3 1 1 1 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3593 PF12159.8 PIK44897.1 - 6.8 6.8 7.4 0.84 9.7 1.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3593) ATP_synt_H PF05493.13 PIK44897.1 - 8.7 6.9 10.9 1 9.9 4.1 2.3 1 1 1 2 2 2 0 ATP synthase subunit H DUF2530 PF10745.9 PIK44897.1 - 9.7 6.5 7.5 25 5.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) ADH_N_2 PF16884.5 PIK44898.1 - 3.4e-22 78.4 0.0 7e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 PIK44898.1 - 6.9e-15 55.2 0.0 1.1e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK44898.1 - 5.3e-11 43.7 0.0 1.6e-10 42.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase BofA PF07441.11 PIK44898.1 - 0.13 12.5 0.5 0.29 11.3 0.5 1.5 1 0 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA ASD2 PF08687.11 PIK44900.1 - 2.2e-45 155.4 14.7 2.2e-45 155.4 14.7 2.1 1 1 1 2 2 2 1 Apx/Shroom domain ASD2 Serine_rich PF08824.10 PIK44900.1 - 0.015 15.3 2.4 0.034 14.2 2.4 1.5 1 0 0 1 1 1 0 Serine rich protein interaction domain RhoGEF PF00621.20 PIK44900.1 - 0.066 13.4 4.7 0.059 13.6 2.8 1.8 1 1 1 2 2 2 0 RhoGEF domain Atg14 PF10186.9 PIK44900.1 - 0.15 11.1 23.4 0.037 13.1 14.9 2.6 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GLTP PF08718.11 PIK44900.1 - 0.26 11.6 2.8 0.68 10.2 2.8 1.7 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) NPV_P10 PF05531.12 PIK44900.1 - 3.3 8.2 9.3 17 6.0 2.0 3.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 PIK44900.1 - 3.4 7.7 15.6 2.9 7.9 1.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) COG2 PF06148.11 PIK44900.1 - 8.9 6.4 14.4 10 6.2 1.1 3.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 LRR_8 PF13855.6 PIK44901.1 - 1.7e-94 309.6 91.9 7.8e-15 54.4 3.1 7.7 2 2 10 12 12 12 12 Leucine rich repeat LRR_5 PF13306.6 PIK44901.1 - 4.8e-23 81.5 11.8 2.8e-08 33.8 0.0 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44901.1 - 5.4e-16 58.4 35.0 0.00029 21.2 4.3 8.0 4 3 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44901.1 - 7.9e-10 38.5 9.5 0.0022 17.5 0.5 4.1 1 1 3 4 4 4 4 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK44901.1 - 0.0021 17.8 26.3 0.31 10.8 6.1 3.9 3 0 0 3 3 3 3 Putative ephrin-receptor like LRR_1 PF00560.33 PIK44901.1 - 2.3 9.1 32.8 6.5 7.7 0.7 10.8 12 1 0 12 12 12 0 Leucine Rich Repeat GIT_SHD PF08518.11 PIK44901.1 - 8.4 6.1 5.9 41 3.9 0.2 3.2 3 0 0 3 3 3 0 Spa2 homology domain (SHD) of GIT LRR_8 PF13855.6 PIK44902.1 - 1.7e-38 130.2 47.8 1.5e-15 56.7 6.3 5.6 2 1 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK44902.1 - 1.2e-15 57.6 1.2 1.1e-08 35.1 0.3 3.3 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44902.1 - 7.6e-10 38.9 31.2 0.0065 16.9 1.5 6.0 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK44902.1 - 0.0025 18.1 21.2 0.18 12.5 0.1 8.1 7 2 0 7 7 7 1 Leucine Rich Repeat LRR_9 PF14580.6 PIK44902.1 - 0.019 14.5 5.8 0.017 14.6 2.5 2.4 2 1 0 2 2 2 0 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK44902.1 - 0.12 12.1 27.7 0.27 11.0 3.9 4.4 4 0 0 4 4 4 0 Putative ephrin-receptor like TRP PF06011.12 PIK44902.1 - 0.17 10.6 1.9 0.16 10.7 0.5 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel TNFR_c6 PF00020.18 PIK44902.1 - 0.46 10.9 0.1 0.46 10.9 0.1 5.2 4 1 1 6 6 6 0 TNFR/NGFR cysteine-rich region LRR_8 PF13855.6 PIK44903.1 - 5.6e-125 407.2 168.4 3.1e-14 52.5 4.5 9.1 1 1 15 16 16 16 16 Leucine rich repeat LRR_5 PF13306.6 PIK44903.1 - 1.4e-26 92.9 18.4 6e-13 48.9 0.5 4.6 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK44903.1 - 2.6e-21 75.3 61.4 7e-06 26.3 0.6 10.4 3 2 10 14 14 14 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK44903.1 - 3.4e-08 33.2 25.4 0.0061 16.1 0.3 5.3 1 1 4 5 5 5 5 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK44903.1 - 0.0044 16.7 21.8 0.2 11.5 3.1 4.0 3 1 0 3 3 3 2 Putative ephrin-receptor like LRR_1 PF00560.33 PIK44903.1 - 0.046 14.3 52.8 2 9.3 0.0 15.2 17 0 0 17 17 17 0 Leucine Rich Repeat DUF697 PF05128.12 PIK44903.1 - 0.091 12.5 0.1 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF697) TNFR_c6 PF00020.18 PIK44903.1 - 1.4 9.4 12.2 0.69 10.4 0.2 3.8 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK44904.1 - 0.00062 19.5 9.2 0.025 14.4 3.8 2.8 1 1 1 2 2 2 2 Putative ephrin-receptor like AC_N PF16214.5 PIK44904.1 - 3 6.9 5.5 0.57 9.2 1.3 1.7 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region TNFR_c6 PF00020.18 PIK44904.1 - 8.2 6.9 8.0 14 6.1 0.9 3.1 1 1 1 2 2 2 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK44905.1 - 0.00016 21.4 27.5 0.0002 21.0 3.1 4.3 4 1 0 4 4 4 3 Putative ephrin-receptor like Nodulin-like PF06813.13 PIK44905.1 - 0.018 14.6 0.0 0.051 13.1 0.0 1.7 1 0 0 1 1 1 0 Nodulin-like TMEM131_like PF12371.8 PIK44908.1 - 2.4e-25 88.6 16.0 2.7e-21 75.6 0.4 6.5 7 0 0 7 7 7 3 Transmembrane protein 131-like ASH PF15780.5 PIK44908.1 - 5.6e-14 52.1 9.7 4.1e-06 26.9 0.0 7.6 8 0 0 8 8 8 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin ELMO_CED12 PF04727.13 PIK44909.1 - 4.8e-42 144.1 0.2 6.1e-42 143.7 0.2 1.1 1 0 0 1 1 1 1 ELMO/CED-12 family DUF2575 PF10837.8 PIK44909.1 - 0.046 14.0 0.2 3.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2575) DUF2277 PF10041.9 PIK44909.1 - 0.2 12.0 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) Pkinase_Tyr PF07714.17 PIK44910.1 - 3e-97 324.9 0.0 3.6e-97 324.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44910.1 - 2.5e-46 158.2 0.0 3e-46 157.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK44910.1 - 1.6e-21 76.1 0.0 4.2e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 PIK44910.1 - 0.019 14.9 0.1 1.6 8.6 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK44910.1 - 0.096 11.6 0.0 0.18 10.7 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Tmemb_14 PF03647.13 PIK44911.1 - 1.8e-23 83.1 12.3 2e-23 83.0 12.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2613 PF11021.8 PIK44911.1 - 2.8 8.1 6.3 0.46 10.6 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2613) SMC_Nse1 PF07574.13 PIK44912.1 - 8.3e-18 65.0 0.4 4e-15 56.2 0.4 2.6 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 PIK44912.1 - 6.6e-06 26.3 9.2 6.6e-06 26.3 9.2 2.3 3 0 0 3 3 3 1 RING-like domain HU-CCDC81_bac_2 PF18175.1 PIK44912.1 - 0.032 14.1 0.1 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 FAM196 PF15265.6 PIK44913.1 - 3.6 7.0 30.9 4.6 6.6 30.9 1.1 1 0 0 1 1 1 0 FAM196 family Fibrinogen_C PF00147.18 PIK44914.1 - 2.3e-46 158.4 5.0 2.7e-46 158.1 5.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Herpes_UL25 PF01499.16 PIK44915.1 - 0.083 11.4 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Fibrinogen_C PF00147.18 PIK44916.1 - 1.2e-62 211.7 12.8 9.2e-62 208.7 10.5 2.1 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK44916.1 - 0.00014 22.0 15.7 0.00014 22.0 15.7 2.4 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK44916.1 - 0.0065 16.4 3.5 0.0065 16.4 3.5 3.3 2 1 1 3 3 3 2 TILa domain EGF_Tenascin PF18720.1 PIK44916.1 - 0.0066 16.5 0.4 0.0066 16.5 0.4 3.3 2 1 0 2 2 2 1 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK44917.1 - 3.9e-71 239.4 9.2 1.9e-41 142.3 5.0 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK44917.1 - 1.6e-06 28.3 16.2 3.5e-06 27.2 16.2 1.6 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK44918.1 - 5.5e-84 281.4 7.7 6.1e-45 153.7 2.3 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK44918.1 - 9.9e-06 25.7 5.5 9.9e-06 25.7 5.5 3.3 3 0 0 3 3 3 1 EGF domain COLFI PF01410.18 PIK44918.1 - 0.00048 19.5 1.1 0.11 11.8 0.1 2.3 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK44918.1 - 0.0013 18.6 1.5 0.0013 18.6 1.5 3.2 1 1 1 2 2 2 1 TILa domain TIL PF01826.17 PIK44918.1 - 0.0037 17.5 11.7 0.0037 17.5 11.7 2.6 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EB PF01683.18 PIK44918.1 - 2.3 8.6 22.6 0.18 12.1 6.2 2.9 2 1 0 2 2 2 0 EB module EGF_MSP1_1 PF12946.7 PIK44918.1 - 5.6 7.1 11.6 1.5 9.0 2.7 2.9 2 1 0 2 2 2 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK44919.1 - 2.2e-95 318.6 12.0 1.2e-64 218.1 9.3 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK44919.1 - 2.4e-06 27.7 19.9 2.4e-06 27.7 19.9 2.3 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_Tenascin PF18720.1 PIK44919.1 - 0.0077 16.3 0.3 0.0077 16.3 0.3 3.2 2 1 0 2 2 2 1 Tenascin EGF domain TILa PF12714.7 PIK44919.1 - 0.009 15.9 3.1 0.009 15.9 3.1 3.1 2 1 1 3 3 3 2 TILa domain Fibrinogen_C PF00147.18 PIK44921.1 - 2e-49 168.4 4.0 2.3e-49 168.2 4.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SMC_Nse1 PF07574.13 PIK44922.1 - 6.2e-25 88.2 0.7 1.6e-22 80.4 0.7 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 PIK44922.1 - 3.9e-09 36.7 6.1 3.9e-09 36.7 6.1 1.8 2 0 0 2 2 2 1 RING-like domain zf-RING_2 PF13639.6 PIK44922.1 - 0.0064 16.8 6.5 0.013 15.8 6.5 1.6 1 0 0 1 1 1 1 Ring finger domain HU-CCDC81_bac_2 PF18175.1 PIK44922.1 - 0.033 14.1 0.1 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 DUF327 PF03885.13 PIK44922.1 - 0.055 13.4 0.7 0.13 12.2 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF327) Zn_ribbon_17 PF17120.5 PIK44922.1 - 0.64 9.7 7.2 0.18 11.4 3.4 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zn-ribbon_8 PF09723.10 PIK44922.1 - 0.77 9.9 6.1 2.7 8.2 3.2 2.7 2 1 0 2 2 2 0 Zinc ribbon domain zf-C3HC4 PF00097.25 PIK44922.1 - 1.3 9.0 6.6 3 7.8 6.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-CHY PF05495.12 PIK44922.1 - 3.3 8.3 8.1 13 6.4 5.8 2.6 2 1 0 2 2 2 0 CHY zinc finger Tmemb_14 PF03647.13 PIK44923.1 - 1.5e-24 86.5 11.8 1.7e-24 86.4 11.8 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2613 PF11021.8 PIK44923.1 - 0.23 11.6 0.4 0.23 11.6 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2613) TssN PF17555.2 PIK44923.1 - 0.29 10.5 0.8 0.33 10.3 0.8 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN Pkinase_Tyr PF07714.17 PIK44924.1 - 6.3e-97 323.9 0.0 8.1e-97 323.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK44924.1 - 5.2e-46 157.1 0.0 6.8e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK44924.1 - 2.9e-21 75.3 0.0 6.7e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK44924.1 - 2.4e-16 59.0 0.2 1.7e-15 56.3 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK44924.1 - 6.8e-10 38.6 0.3 2.2e-09 37.0 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK44924.1 - 1.4e-06 27.9 0.0 5.1e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain APH PF01636.23 PIK44924.1 - 0.04 13.8 0.1 2.8 7.8 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK44924.1 - 0.17 10.8 0.0 0.3 10.0 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain SH3_3 PF08239.11 PIK44924.1 - 0.23 11.8 1.0 0.48 10.8 0.1 2.0 2 0 0 2 2 2 0 Bacterial SH3 domain DUSP PF06337.12 PIK44926.1 - 2e-18 66.8 0.0 2.2e-08 34.6 0.0 2.2 2 0 0 2 2 2 2 DUSP domain DUSP PF06337.12 PIK44927.1 - 3.5e-11 43.6 0.1 2.2e-09 37.8 0.2 2.6 2 1 0 2 2 2 2 DUSP domain UCH PF00443.29 PIK44928.1 - 3.4e-24 85.7 1.3 5.8e-24 85.0 1.3 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 PIK44928.1 - 1.6e-10 41.2 2.2 1.6e-10 41.2 2.2 3.0 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 PIK44928.1 - 4.7e-07 29.7 1.8 0.0063 16.2 0.0 3.2 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Defensin_3 PF08131.11 PIK44929.1 - 0.85 9.9 6.6 46 4.3 0.2 3.3 3 0 0 3 3 3 0 Defensin-like peptide family RasGAP PF00616.19 PIK44930.1 - 8.8e-15 55.0 0.1 6.3e-11 42.4 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 PIK44930.1 - 2.6e-09 37.3 0.0 4.7e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain PH PF00169.29 PIK44930.1 - 0.0058 17.1 0.1 0.031 14.8 0.0 2.2 3 0 0 3 3 3 1 PH domain PH_2 PF08458.10 PIK44930.1 - 0.097 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region DUF3498 PF12004.8 PIK44931.1 - 1.5e-11 44.2 16.1 1.5e-11 44.2 16.1 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3498) DUF16 PF01519.16 PIK44931.1 - 0.02 15.3 2.5 0.02 15.3 2.5 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 CDC37_N PF03234.14 PIK44931.1 - 0.06 14.3 0.7 0.06 14.3 0.7 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding SlyX PF04102.12 PIK44931.1 - 0.13 12.9 0.3 0.13 12.9 0.3 3.0 3 1 0 3 3 2 0 SlyX PKcGMP_CC PF16808.5 PIK44931.1 - 0.16 11.8 0.2 0.16 11.8 0.2 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FlaC_arch PF05377.11 PIK44931.1 - 0.38 11.2 6.3 7.7 7.0 0.2 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF848 PF05852.11 PIK44931.1 - 0.57 10.3 7.3 0.38 10.9 0.4 2.3 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) GAS PF13851.6 PIK44931.1 - 0.82 9.0 21.8 0.45 9.8 4.2 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 PIK44931.1 - 1.3 9.4 14.3 0.16 12.4 0.8 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ATG16 PF08614.11 PIK44931.1 - 1.5 9.0 21.0 0.5 10.6 7.2 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) OrfB_IS605 PF01385.19 PIK44931.1 - 3.5 7.9 7.3 0.29 11.4 2.2 1.8 2 0 0 2 2 2 0 Probable transposase KOG2701 PF09762.9 PIK44931.1 - 5.5 7.2 8.9 0.19 12.0 1.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein (DUF2037) VWC PF00093.18 PIK44932.1 - 4.8e-08 33.2 17.5 4.8e-08 33.2 17.5 3.9 4 0 0 4 4 4 1 von Willebrand factor type C domain CFC PF09443.10 PIK44932.1 - 0.025 14.4 3.1 0.1 12.5 3.1 2.0 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) WD40 PF00400.32 PIK44933.1 - 2.7e-28 97.6 1.9 1.4e-09 38.4 0.0 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44933.1 - 6.4e-09 36.0 0.0 0.13 12.6 0.0 3.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK44933.1 - 0.00037 19.6 0.0 0.17 10.8 0.0 3.0 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK44933.1 - 0.0045 16.4 0.0 0.027 13.8 0.0 2.1 2 1 0 2 2 2 1 WD40-like domain Peptidase_S9_N PF02897.15 PIK44933.1 - 0.012 14.4 0.0 0.23 10.2 0.1 2.4 1 1 1 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Thioredoxin PF00085.20 PIK44935.1 - 7.2e-73 241.1 0.2 6.3e-24 83.9 0.1 5.2 5 0 0 5 5 5 4 Thioredoxin Thioredoxin_8 PF13905.6 PIK44935.1 - 1.7e-11 44.2 0.1 0.013 15.8 0.0 4.7 3 1 1 4 4 4 3 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK44935.1 - 2e-10 41.1 4.0 0.14 12.6 0.1 5.5 4 2 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_6 PF13848.6 PIK44935.1 - 3e-10 40.3 0.0 0.019 14.9 0.0 4.5 3 2 2 5 5 5 3 Thioredoxin-like domain OST3_OST6 PF04756.13 PIK44935.1 - 1.4e-09 37.7 0.1 0.081 12.3 0.1 4.1 3 1 1 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 PIK44935.1 - 4.4e-07 29.7 1.4 0.11 12.2 0.0 3.7 3 0 0 3 3 3 3 Thioredoxin AhpC-TSA PF00578.21 PIK44935.1 - 1.1e-06 28.6 1.4 0.028 14.3 0.0 4.2 4 0 0 4 4 4 1 AhpC/TSA family Redoxin PF08534.10 PIK44935.1 - 3.1e-05 23.7 1.0 0.043 13.5 0.0 3.4 2 1 1 3 3 3 1 Redoxin Thioredoxin_7 PF13899.6 PIK44935.1 - 3.4e-05 23.9 0.3 0.074 13.2 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 PIK44935.1 - 0.00086 19.3 0.5 1.4 9.0 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin domain HlyC PF02794.16 PIK44935.1 - 0.026 14.4 0.0 11 5.9 0.0 3.0 3 0 0 3 3 3 0 RTX toxin acyltransferase family Thioredoxin_5 PF13743.6 PIK44935.1 - 0.036 13.7 0.5 22 4.7 0.0 3.6 3 1 0 4 4 4 0 Thioredoxin TraF PF13728.6 PIK44935.1 - 0.091 12.6 1.1 9.6 6.0 0.0 3.1 3 0 0 3 3 3 0 F plasmid transfer operon protein DnaJ PF00226.31 PIK44936.1 - 6.3e-24 83.9 2.9 9.2e-24 83.3 2.9 1.3 1 0 0 1 1 1 1 DnaJ domain DZR PF12773.7 PIK44937.1 - 0.043 13.9 3.1 0.081 13.0 3.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon NOB1_Zn_bind PF08772.11 PIK44937.1 - 0.19 11.9 3.8 0.49 10.6 3.8 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 PIK44937.1 - 0.67 9.8 7.4 1.2 8.9 7.4 1.4 1 0 0 1 1 1 0 zinc-ribbon domain WHIM1 PF15612.6 PIK44938.1 - 2.1e-09 36.7 0.8 4.4 7.0 0.0 8.4 6 2 4 10 10 10 3 WSTF, HB1, Itc1p, MBD9 motif 1 DUF551 PF04448.12 PIK44938.1 - 7.7e-06 26.8 0.3 41 5.2 0.1 4.9 1 1 6 7 7 7 0 Protein of unknown function (DUF551) Inhibitor_I78 PF11720.8 PIK44938.1 - 2.9e-05 24.0 0.1 61 3.8 0.0 6.2 1 1 6 8 8 8 0 Peptidase inhibitor I78 family COX4_pro_2 PF07835.12 PIK44938.1 - 0.00022 21.3 0.0 28 4.9 0.0 5.2 8 2 1 9 9 9 2 Bacterial aa3 type cytochrome c oxidase subunit IV DUF2807 PF10988.8 PIK44938.1 - 0.044 13.6 0.0 4.8 6.9 0.0 2.3 1 1 1 2 2 2 0 Putative auto-transporter adhesin, head GIN domain DUF4333 PF14230.6 PIK44938.1 - 0.072 13.3 0.3 7.9 6.8 0.1 3.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4333) Peptidase_M14 PF00246.24 PIK44939.1 - 5.3e-74 249.6 0.1 6.3e-74 249.4 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK44939.1 - 3.9e-09 36.8 0.0 9.7e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide WD40 PF00400.32 PIK44940.1 - 6.3e-28 96.5 33.4 0.024 15.5 0.0 13.7 14 0 0 14 14 14 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK44940.1 - 5.1e-11 42.7 0.0 0.078 13.3 0.0 7.1 3 3 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK44940.1 - 1.6e-08 33.7 5.3 0.0044 15.7 0.0 4.8 6 0 0 6 6 6 3 Nucleoporin Nup120/160 PQQ_3 PF13570.6 PIK44940.1 - 0.0035 17.8 0.1 8.3 7.0 0.0 4.9 5 0 0 5 5 5 1 PQQ-like domain Cytochrom_D1 PF02239.16 PIK44940.1 - 0.0036 15.9 0.0 0.61 8.6 0.0 2.7 3 0 0 3 3 3 2 Cytochrome D1 heme domain DUF4062 PF13271.6 PIK44941.1 - 6.7e-13 48.8 0.0 4e-12 46.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) AAA_16 PF13191.6 PIK44941.1 - 2.2e-09 37.9 0.0 1e-08 35.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 PIK44941.1 - 1.1e-08 35.2 0.1 4e-08 33.4 0.1 1.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK44941.1 - 0.00012 22.3 0.0 0.00081 19.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 PIK44941.1 - 0.00086 19.3 0.1 10 6.2 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 PIK44941.1 - 0.0027 18.2 0.0 0.42 11.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 PIK44941.1 - 0.0095 16.4 0.1 0.075 13.5 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RVT_3 PF13456.6 PIK44941.1 - 0.051 13.4 0.1 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase-like ATPase_2 PF01637.18 PIK44941.1 - 0.11 12.4 0.1 0.53 10.2 0.0 2.3 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea ClpB_D2-small PF10431.9 PIK44941.1 - 0.13 12.4 0.0 2.7 8.1 0.0 2.9 3 0 0 3 3 3 0 C-terminal, D2-small domain, of ClpB protein DUF5601 PF18151.1 PIK44941.1 - 0.48 10.8 4.6 0.59 10.5 1.2 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF5601) G-alpha PF00503.20 PIK44941.1 - 0.97 8.5 5.3 1.4 8.0 0.7 2.8 2 1 1 3 3 3 0 G-protein alpha subunit Lipase_GDSL_2 PF13472.6 PIK44943.1 - 7.5e-14 52.5 0.0 1.3e-13 51.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.6 PIK44943.1 - 2.3e-06 27.9 0.0 3.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK44943.1 - 2.9e-05 24.1 0.0 9e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase EOS1 PF12326.8 PIK44944.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein Urb2 PF10441.9 PIK44945.1 - 0.00014 21.9 0.1 0.00014 21.9 0.1 4.0 4 1 1 5 5 5 1 Urb2/Npa2 family SKA1 PF07160.12 PIK44945.1 - 0.029 14.2 0.8 0.09 12.6 0.3 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF4508 PF14969.6 PIK44945.1 - 0.18 12.1 2.8 0.24 11.7 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) zf-C4 PF00105.18 PIK44946.1 - 2.5e-30 104.7 19.5 4.9e-30 103.8 19.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK44946.1 - 2.6e-17 63.1 2.9 4.3e-17 62.4 2.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor RVT_1 PF00078.27 PIK44947.1 - 1.4e-20 73.8 0.1 2e-20 73.3 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FYVE_2 PF02318.16 PIK44949.1 - 1e-30 106.4 17.6 1.5e-30 105.8 17.6 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger Stm1_N PF09598.10 PIK44949.1 - 0.023 15.5 2.3 0.071 14.0 2.3 1.8 1 0 0 1 1 1 0 Stm1 FYVE PF01363.21 PIK44949.1 - 0.32 11.2 16.7 0.18 12.0 13.8 2.0 2 0 0 2 2 2 0 FYVE zinc finger Apt1 PF10351.9 PIK44949.1 - 1.9 7.3 7.8 3.6 6.4 7.8 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM104 PF15434.6 PIK44949.1 - 4.7 7.8 13.4 1.9 9.1 8.8 2.3 2 0 0 2 2 2 0 Family 104 DUF4349 PF14257.6 PIK44950.1 - 0.0045 16.5 0.1 0.01 15.3 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4349) MtrB PF05440.12 PIK44950.1 - 0.049 14.0 0.1 0.095 13.1 0.1 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF3452 PF11934.8 PIK44950.1 - 0.11 12.1 2.0 2.5 7.7 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) BLOC1_2 PF10046.9 PIK44950.1 - 0.15 12.4 3.7 0.13 12.5 1.7 1.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 PIK44950.1 - 0.69 10.1 7.3 0.31 11.2 2.0 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family zf-Di19 PF05605.12 PIK44953.1 - 0.0015 18.7 0.9 0.0031 17.8 0.9 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 PIK44953.1 - 0.017 15.0 6.0 1.8 8.5 0.3 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 TMEM95 PF15203.6 PIK44953.1 - 0.02 14.6 1.1 0.025 14.2 1.1 1.1 1 0 0 1 1 1 0 TMEM95 family zf-ACC PF17848.1 PIK44953.1 - 0.034 14.2 0.7 3.4 7.8 0.1 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF3797 PF12677.7 PIK44953.1 - 0.14 12.1 0.7 19 5.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zf-CHY PF05495.12 PIK44953.1 - 0.23 12.0 4.5 0.33 11.5 4.5 1.3 1 0 0 1 1 1 0 CHY zinc finger Mut7-C PF01927.16 PIK44953.1 - 0.43 10.7 3.5 0.53 10.4 3.5 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain zf-C3HC4_3 PF13920.6 PIK44953.1 - 1.6 8.6 6.4 8.8 6.3 0.4 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) CLASP_N PF12348.8 PIK44954.1 - 0.015 14.8 0.0 0.038 13.6 0.0 1.6 2 0 0 2 2 2 0 CLASP N terminal DUF4371 PF14291.6 PIK44957.1 - 9.2e-32 110.6 0.2 1.3e-31 110.1 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Integrase_H2C2 PF17921.1 PIK44958.1 - 1.2e-15 57.3 0.7 1.2e-15 57.3 0.7 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK44958.1 - 1.5e-08 34.8 0.1 2.9e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK44959.1 - 2.6e-25 89.3 0.0 3.1e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YmgB PF10798.8 PIK44960.1 - 0.084 12.7 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Peptidase_A17 PF05380.13 PIK44961.1 - 1e-09 38.6 0.0 4e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 Pao retrotransposon peptidase EGF PF00008.27 PIK44962.1 - 2.8e-172 558.2 401.9 1.4e-08 34.9 5.3 28.3 28 0 0 28 28 28 28 EGF-like domain hEGF PF12661.7 PIK44962.1 - 1.9e-94 307.4 343.6 2.4e-06 28.0 3.9 30.1 28 0 0 28 28 28 26 Human growth factor-like EGF EGF_CA PF07645.15 PIK44962.1 - 4.7e-67 222.0 416.2 1.6e-07 31.4 8.1 28.3 19 7 9 28 28 28 25 Calcium-binding EGF domain EGF_2 PF07974.13 PIK44962.1 - 1.1e-27 96.0 470.7 0.0021 18.4 9.8 28.5 28 0 0 28 28 28 21 EGF-like domain EGF_3 PF12947.7 PIK44962.1 - 3.6e-10 39.9 360.9 0.014 15.6 5.3 28.9 24 5 4 28 28 28 18 EGF domain FXa_inhibition PF14670.6 PIK44962.1 - 8.5e-05 22.7 370.8 0.041 14.2 9.0 28.6 9 6 19 28 28 28 15 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK44963.1 - 5.7e-75 247.1 252.5 3.2e-07 30.5 5.0 18.7 18 0 0 18 18 18 17 EGF-like domain hEGF PF12661.7 PIK44963.1 - 3.6e-33 113.0 225.3 6e-06 26.7 4.6 19.8 19 1 0 19 19 19 14 Human growth factor-like EGF Laminin_G_2 PF02210.24 PIK44963.1 - 6.7e-32 110.7 0.0 2.3e-15 57.3 0.1 3.9 4 0 0 4 4 4 3 Laminin G domain Laminin_G_1 PF00054.23 PIK44963.1 - 1.8e-23 83.2 0.0 7e-12 45.7 0.0 3.8 4 0 0 4 4 4 3 Laminin G domain EGF_CA PF07645.15 PIK44963.1 - 1e-17 64.0 37.2 8.5e-10 38.7 4.9 18.7 10 6 8 18 18 18 6 Calcium-binding EGF domain EGF_3 PF12947.7 PIK44963.1 - 4.6e-05 23.5 3.2 4.6e-05 23.5 3.2 18.9 15 2 3 18 18 18 13 EGF domain FXa_inhibition PF14670.6 PIK44963.1 - 0.0033 17.7 9.1 0.0033 17.7 9.1 18.5 10 5 8 18 18 18 7 Coagulation Factor Xa inhibitory site DUF3169 PF11368.8 PIK44963.1 - 0.045 13.3 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Ribosomal_S18 PF01084.20 PIK44964.1 - 1.9e-14 53.6 0.0 3.8e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 DUF5318 PF17249.2 PIK44964.1 - 0.097 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5318) TF_Zn_Ribbon PF08271.12 PIK44964.1 - 0.1 12.1 0.1 0.23 11.0 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Med26 PF08711.11 PIK44965.1 - 0.00019 21.4 0.4 0.00056 19.9 0.4 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain TDH PF03347.13 PIK44965.1 - 0.023 14.2 0.0 0.058 13.0 0.0 1.6 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin ABC_tran PF00005.27 PIK44967.1 - 5.4e-28 98.2 0.0 1e-27 97.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK44967.1 - 1.1e-15 57.7 23.2 2.9e-15 56.2 23.2 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 PIK44967.1 - 6.1e-09 36.1 0.1 7.8e-06 25.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4231 PF14015.6 PIK44967.1 - 0.033 14.7 0.9 0.033 14.7 0.9 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF4231) AAA_23 PF13476.6 PIK44967.1 - 0.092 13.2 0.8 0.13 12.7 0.1 1.6 2 0 0 2 2 2 0 AAA domain BPD_transp_1 PF00528.22 PIK44967.1 - 4.3 7.0 12.8 0.046 13.5 1.7 2.4 1 1 1 2 2 2 0 Binding-protein-dependent transport system inner membrane component ECH_1 PF00378.20 PIK44968.1 - 9.1e-30 103.8 0.0 1.2e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK44968.1 - 2.4e-08 33.9 0.0 3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK44968.1 - 0.0018 18.3 0.0 0.016 15.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase family S49 7tm_2 PF00002.24 PIK44969.1 - 1.2e-39 136.1 22.0 1.7e-39 135.6 22.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) IgGFc_binding PF17517.2 PIK44969.1 - 2.5e-30 105.8 0.6 2.5e-30 105.8 0.6 2.0 2 0 0 2 2 2 1 IgGFc binding protein GPS PF01825.21 PIK44969.1 - 5.1e-16 58.9 4.9 1.1e-15 57.8 4.9 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TraL PF07178.11 PIK44969.1 - 0.01 16.2 0.8 0.066 13.7 0.3 2.6 2 1 0 2 2 2 0 TraL protein Aconitase_2_N PF06434.13 PIK44969.1 - 0.015 14.9 0.2 0.036 13.7 0.2 1.6 1 0 0 1 1 1 0 Aconitate hydratase 2 N-terminus TMP_2 PF06791.13 PIK44969.1 - 0.052 13.2 1.4 0.088 12.5 0.6 1.7 2 0 0 2 2 2 0 Prophage tail length tape measure protein TNFR_16_TM PF18422.1 PIK44969.1 - 0.069 13.1 0.3 0.72 9.9 0.1 2.6 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF4131 PF13567.6 PIK44969.1 - 0.53 9.9 5.0 6.4 6.4 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ABC2_membrane PF01061.24 PIK44970.1 - 4.6e-35 121.0 15.2 6.5e-35 120.5 15.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 PIK44970.1 - 5.1e-23 82.1 0.0 9.5e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK44970.1 - 8.7e-05 21.8 12.4 8.7e-05 21.8 12.4 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein SMC_N PF02463.19 PIK44970.1 - 0.0031 17.0 0.0 0.013 15.0 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 PIK44970.1 - 0.0052 16.7 0.1 0.009 15.9 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 PIK44970.1 - 0.0061 16.4 1.2 0.73 9.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 PIK44970.1 - 0.008 16.5 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 PIK44970.1 - 0.027 14.2 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 PIK44970.1 - 0.027 14.9 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 PIK44970.1 - 0.031 14.0 0.1 0.063 13.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 PIK44970.1 - 0.051 13.5 0.1 2.2 8.2 0.1 2.2 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 PIK44970.1 - 0.056 14.0 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 PIK44970.1 - 0.058 13.6 0.3 0.13 12.5 0.3 1.5 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 PIK44970.1 - 0.1 11.4 0.2 0.15 10.8 0.2 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class cobW PF02492.19 PIK44970.1 - 0.12 12.0 0.4 0.21 11.2 0.4 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 PIK44970.1 - 0.13 11.8 0.1 0.25 10.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK44970.1 - 0.16 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 PIK44970.1 - 0.2 10.9 0.1 1 8.6 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 PIK44970.1 - 0.21 12.1 0.8 0.44 11.0 0.8 1.4 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.8 PIK44971.1 - 0.0018 18.3 30.9 0.012 15.6 2.9 3.3 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 PIK44971.1 - 0.11 12.7 29.9 1.5 9.0 21.8 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.11 PIK44971.1 - 0.17 10.7 31.1 0.23 10.3 31.1 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Med21 PF11221.8 PIK44971.1 - 0.2 11.9 19.8 0.039 14.2 9.8 2.6 1 1 2 3 3 3 0 Subunit 21 of Mediator complex DUF812 PF05667.11 PIK44971.1 - 0.22 10.4 29.1 0.75 8.6 29.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Fez1 PF06818.15 PIK44971.1 - 0.27 11.7 30.1 0.33 11.4 16.2 2.2 1 1 1 2 2 2 0 Fez1 Cob_adeno_trans PF01923.18 PIK44971.1 - 0.62 10.2 12.2 3.5 7.8 1.4 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase FAM76 PF16046.5 PIK44971.1 - 0.82 9.0 30.3 6.2 6.1 13.9 2.6 1 1 1 2 2 2 0 FAM76 protein UPF0242 PF06785.11 PIK44971.1 - 1.2 9.2 29.5 0.23 11.6 13.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Mod_r PF07200.13 PIK44971.1 - 1.3 9.1 28.5 3.5 7.7 17.6 2.8 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 PIK44971.1 - 1.3 7.8 32.9 4.8 6.0 23.4 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein MCC-bdg_PDZ PF10506.9 PIK44971.1 - 1.6 8.8 9.2 0.26 11.3 1.7 3.0 2 2 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF4407 PF14362.6 PIK44971.1 - 1.7 7.9 15.3 0.33 10.2 8.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Tropomyosin_1 PF12718.7 PIK44971.1 - 1.8 8.7 36.7 4.8 7.3 22.0 2.2 1 1 1 2 2 2 0 Tropomyosin like Syntaxin_2 PF14523.6 PIK44971.1 - 2.9 8.3 19.9 1.6 9.2 9.7 2.6 1 1 1 2 2 2 0 Syntaxin-like protein APG6_N PF17675.1 PIK44971.1 - 3 8.4 33.6 16 6.0 16.5 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region Adaptin_binding PF10199.9 PIK44971.1 - 3.6 8.2 20.6 4.1 8.0 7.2 2.3 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 zf-C4H2 PF10146.9 PIK44971.1 - 5.2 7.3 31.2 2.4 8.4 16.9 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein DivIC PF04977.15 PIK44971.1 - 5.5 6.8 27.4 2.7 7.8 1.5 4.3 2 2 1 4 4 4 0 Septum formation initiator DUF641 PF04859.12 PIK44971.1 - 7.6 6.9 28.1 4.4 7.6 9.2 3.4 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF4797 PF16051.5 PIK44972.1 - 0.12 12.3 0.4 0.3 11.1 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4797) Filament PF00038.21 PIK44974.1 - 0.0013 18.4 61.4 0.044 13.4 10.1 3.9 1 1 3 4 4 4 4 Intermediate filament protein Lectin_N PF03954.14 PIK44974.1 - 0.021 14.6 2.5 0.021 14.6 2.5 4.9 3 2 1 4 4 4 0 Hepatic lectin, N-terminal domain Golgin_A5 PF09787.9 PIK44974.1 - 1.9 7.9 65.1 3.8 6.9 16.3 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 Spc7 PF08317.11 PIK44974.1 - 4.1 6.2 62.6 0.051 12.5 20.5 4.9 1 1 4 5 5 5 0 Spc7 kinetochore protein DUF3584 PF12128.8 PIK44974.1 - 8.2 3.8 50.0 1.4e+02 -0.3 50.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 PIK44975.1 - 0.0029 16.5 18.3 0.0029 16.5 18.3 4.7 1 1 1 4 4 4 3 Spc7 kinetochore protein Lectin_N PF03954.14 PIK44975.1 - 0.0037 17.0 3.5 0.0037 17.0 3.5 5.5 4 2 1 6 6 6 1 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 PIK44975.1 - 0.025 14.6 1.9 0.025 14.6 1.9 6.3 1 1 4 6 6 6 0 Protein of unknown function (DUF1664) DivIC PF04977.15 PIK44975.1 - 0.027 14.2 1.1 0.027 14.2 1.1 7.4 7 2 1 8 8 8 0 Septum formation initiator Filament PF00038.21 PIK44975.1 - 0.15 11.6 80.9 0.018 14.6 10.9 4.8 2 1 2 4 4 4 0 Intermediate filament protein MM_CoA_mutase PF01642.22 PIK44976.1 - 6e-117 391.3 0.0 7.3e-117 391.0 0.0 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase Soc PF16855.5 PIK44976.1 - 0.13 12.8 0.0 0.75 10.3 0.0 2.3 2 0 0 2 2 2 0 Small outer capsid protein MM_CoA_mutase PF01642.22 PIK44977.1 - 2.6e-79 267.1 0.7 4.2e-79 266.5 0.7 1.3 1 1 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 PIK44977.1 - 1.7e-14 53.9 0.1 3.9e-14 52.7 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain Arm PF00514.23 PIK44978.1 - 0.22 11.6 2.6 0.77 9.9 0.3 2.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Pkinase PF00069.25 PIK44979.1 - 1.5e-55 188.4 0.0 2.7e-55 187.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44979.1 - 8e-38 130.2 0.0 1.1e-37 129.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK44979.1 - 7.4e-09 35.0 0.0 1.6e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK44979.1 - 2.1e-06 27.3 0.1 1e-05 25.0 0.0 2.2 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 PIK44979.1 - 2.2e-05 24.5 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK44979.1 - 3.2e-05 23.6 0.6 8.3e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 PIK44979.1 - 4.5e-05 22.4 0.0 9.4e-05 21.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF4692 PF15763.5 PIK44979.1 - 0.027 15.0 1.5 0.063 13.7 1.2 1.8 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Fe_bilin_red PF05996.12 PIK44979.1 - 0.24 11.1 1.2 1.1 8.8 0.0 2.3 2 1 1 3 3 3 0 Ferredoxin-dependent bilin reductase Peptidase_C48 PF02902.19 PIK44981.1 - 1.7e-44 152.3 0.2 3e-44 151.4 0.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 PIK44981.1 - 0.0073 15.1 0.1 2.6 6.7 0.0 2.2 2 0 0 2 2 2 2 Vaccinia virus I7 processing peptidase Integrin_alpha2 PF08441.12 PIK44982.1 - 2.8e-64 217.7 2.1 4.1e-64 217.2 2.1 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK44982.1 - 1.4e-21 76.2 26.0 9.4e-09 35.2 1.3 5.1 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.6 PIK44982.1 - 2.7e-12 47.1 11.2 1.3e-05 25.7 3.7 4.2 2 1 3 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 PIK44982.1 - 0.0015 17.9 1.1 3.4 7.0 0.1 3.7 2 1 2 4 4 4 2 Insecticide toxin TcdB middle/N-terminal region Piwi PF02171.17 PIK44982.1 - 0.018 14.3 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Piwi domain FG-GAP_2 PF14312.6 PIK44982.1 - 0.049 13.9 5.9 2.6 8.4 0.2 4.0 4 0 0 4 4 4 0 FG-GAP repeat Arm PF00514.23 PIK44983.1 - 1.3e-39 133.0 20.2 3.3e-09 36.5 0.0 9.3 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK44983.1 - 6.3e-15 55.3 13.0 0.0011 19.3 0.1 5.3 1 1 2 5 5 5 4 HEAT repeats HEAT PF02985.22 PIK44983.1 - 2.6e-14 52.1 9.4 0.001 19.2 0.0 7.6 8 0 0 8 8 8 4 HEAT repeat Cnd1 PF12717.7 PIK44983.1 - 1.5e-12 47.9 1.6 0.011 15.8 0.1 5.1 1 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK44983.1 - 8.7e-11 42.1 14.8 0.002 18.6 0.4 6.3 4 2 2 6 6 6 5 HEAT-like repeat DNA_alkylation PF08713.11 PIK44983.1 - 1.4e-08 34.7 0.1 0.16 11.7 0.0 4.0 2 1 1 4 4 4 2 DNA alkylation repair enzyme CHASE6_C PF17150.4 PIK44983.1 - 3.8e-07 30.7 0.5 1 10.1 0.1 6.4 4 2 1 6 6 6 1 C-terminal domain of two-partite extracellular sensor domain Adaptin_N PF01602.20 PIK44983.1 - 3.4e-06 25.9 6.5 0.0038 15.9 0.7 3.9 1 1 0 3 3 3 3 Adaptin N terminal region Proteasom_PSMB PF10508.9 PIK44983.1 - 3.9e-05 22.4 6.3 0.0016 17.0 0.4 2.9 1 1 2 3 3 3 3 Proteasome non-ATPase 26S subunit HEAT_PBS PF03130.16 PIK44983.1 - 4.2e-05 23.8 7.4 0.091 13.5 0.3 4.6 3 0 0 3 3 3 2 PBS lyase HEAT-like repeat RTP1_C1 PF10363.9 PIK44983.1 - 0.00023 21.3 0.5 0.13 12.5 0.1 3.0 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 API5 PF05918.11 PIK44983.1 - 0.00089 18.2 4.2 0.83 8.4 0.9 3.6 2 1 1 4 4 4 2 Apoptosis inhibitory protein 5 (API5) V-ATPase_H_C PF11698.8 PIK44983.1 - 0.016 15.3 0.9 19 5.4 0.0 3.9 4 0 0 4 4 4 0 V-ATPase subunit H CLASP_N PF12348.8 PIK44983.1 - 0.029 13.9 0.1 2.5 7.6 0.0 2.7 2 0 0 2 2 2 0 CLASP N terminal DUF3731 PF12531.8 PIK44983.1 - 0.054 13.3 6.2 6.5 6.5 0.2 3.4 3 1 0 3 3 3 0 DNA-K related protein Mo25 PF08569.11 PIK44983.1 - 0.066 12.6 0.4 2.8 7.2 0.1 2.6 1 1 1 2 2 2 0 Mo25-like Vac14_Fab1_bd PF12755.7 PIK44983.1 - 0.089 13.4 1.0 1.3 9.7 0.1 3.4 4 2 0 4 4 4 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 PIK44983.1 - 0.089 11.9 5.4 4.4 6.3 0.1 3.4 3 1 1 4 4 4 0 RNAPII transcription regulator C-terminal TPR_16 PF13432.6 PIK44983.1 - 0.21 12.2 8.9 2.7 8.7 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3361 PF11841.8 PIK44983.1 - 3.6 7.5 8.2 5.2 7.0 0.3 3.8 3 2 1 4 4 4 0 Domain of unknown function (DUF3361) Proteasome PF00227.26 PIK44984.1 - 1e-38 132.8 0.0 1.1e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit 2OG-FeII_Oxy_3 PF13640.6 PIK44985.1 - 1.9e-12 47.9 0.0 4e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Rota_NSP3 PF01665.16 PIK44985.1 - 0.12 11.5 3.3 0.16 11.1 3.3 1.2 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 Peptidase_A17 PF05380.13 PIK44986.1 - 5.7e-51 172.7 0.0 9.9e-51 172.0 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF5641 PF18701.1 PIK44986.1 - 1.4e-25 89.3 4.8 3.7e-25 87.9 4.8 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 PIK44986.1 - 1.4e-06 28.3 2.4 4.8e-06 26.6 2.4 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK44986.1 - 0.0044 17.0 2.2 0.037 14.1 0.3 3.1 2 0 0 2 2 2 1 Zinc knuckle DUF1759 PF03564.15 PIK44986.1 - 0.09 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DNA_pol_viral_C PF00336.18 PIK44986.1 - 0.096 12.1 0.0 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain DUF3104 PF11302.8 PIK44986.1 - 0.13 12.1 0.1 3.1 7.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) DUF1841 PF08897.11 PIK44986.1 - 0.13 12.3 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) zf-H2C2 PF09337.10 PIK44986.1 - 0.52 10.6 4.5 1.4 9.2 1.7 3.1 3 0 0 3 3 3 0 H2C2 zinc finger AAA_6 PF12774.7 PIK44988.1 - 5.3e-63 213.0 0.0 5e-32 111.2 0.0 3.3 2 1 1 3 3 3 3 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK44988.1 - 7.7e-20 71.4 1.9 1.2e-13 50.9 0.0 2.8 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 2 AAA_22 PF13401.6 PIK44988.1 - 3.2e-06 27.5 0.9 0.13 12.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 PIK44988.1 - 4.4e-06 26.3 0.2 0.016 14.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 PIK44988.1 - 0.00014 22.3 0.1 1.3 9.5 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK44988.1 - 0.00023 21.2 0.0 0.42 10.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) T2SSE PF00437.20 PIK44988.1 - 0.00037 19.6 0.0 0.028 13.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 PIK44988.1 - 0.00043 20.7 0.5 1.1 9.6 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 PIK44988.1 - 0.0087 15.8 0.1 0.88 9.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 PIK44988.1 - 0.0088 15.4 0.1 0.13 11.6 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 PIK44988.1 - 0.014 15.6 0.2 0.52 10.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 PIK44988.1 - 0.016 15.6 0.6 0.53 10.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 PIK44988.1 - 0.027 14.5 0.2 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 PIK44988.1 - 0.056 14.0 0.0 9.5 6.8 0.0 3.1 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 PIK44988.1 - 0.11 12.3 0.1 17 5.1 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PIN_8 PF18476.1 PIK44988.1 - 0.14 12.0 0.9 4.9 7.0 0.2 3.0 3 0 0 3 3 3 0 PIN like domain L27 PF02828.16 PIK44988.1 - 0.15 11.9 0.9 12 5.7 0.1 3.2 2 0 0 2 2 2 0 L27 domain SRP54 PF00448.22 PIK44988.1 - 0.16 11.6 0.0 4.5 6.8 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 PIK44988.1 - 0.17 12.3 0.0 5.2 7.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 PIK44988.1 - 0.24 11.3 1.5 2.7 7.9 0.0 3.2 3 0 0 3 3 3 0 NACHT domain Transformer PF06495.11 PIK44988.1 - 0.56 10.3 4.7 1.4 9.0 4.7 1.6 1 0 0 1 1 1 0 Fruit fly transformer protein AAA_28 PF13521.6 PIK44988.1 - 0.75 10.0 3.1 18 5.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain Myc-LZ PF02344.15 PIK44988.1 - 1 9.5 5.0 2 8.6 1.1 2.7 2 0 0 2 2 2 0 Myc leucine zipper domain Dynein_AAA_lid PF17852.1 PIK44989.1 - 2.2e-11 44.0 0.0 9.9e-11 41.8 0.0 2.1 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 PIK44989.1 - 7.4e-11 41.9 0.0 5.7e-09 35.7 0.0 2.2 1 1 1 2 2 2 2 P-loop containing dynein motor region Pkinase PF00069.25 PIK44990.1 - 3.1e-61 207.0 0.2 1.4e-60 204.9 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK44990.1 - 3.4e-43 147.8 0.0 7.3e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK44990.1 - 1.2e-05 24.8 0.0 0.008 15.5 0.0 2.9 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 PIK44990.1 - 0.23 11.3 0.0 0.58 10.0 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Ank_5 PF13857.6 PIK44991.1 - 3.2e-32 110.2 1.1 5.8e-11 42.4 0.3 5.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK44991.1 - 1.7e-30 105.4 0.1 3.7e-10 40.3 0.0 4.4 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK44991.1 - 2.6e-30 104.4 0.2 2.5e-06 27.9 0.0 6.2 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK44991.1 - 7.7e-28 95.7 7.9 5.5e-09 36.1 0.1 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 PIK44991.1 - 3.7e-24 82.2 2.6 4.5e-06 26.6 0.0 7.9 8 1 0 8 8 8 4 Ankyrin repeat Shigella_OspC PF06128.11 PIK44991.1 - 0.065 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Shigella flexneri OspC protein SH3_1 PF00018.28 PIK44992.1 - 1e-11 44.2 0.0 1.7e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK44992.1 - 2.7e-09 36.6 0.0 3.3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK44992.1 - 2.2e-08 33.8 0.0 2.9e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain Kinesin PF00225.23 PIK44994.1 - 1.2e-64 218.4 0.4 1.2e-64 218.4 0.4 1.7 2 0 0 2 2 2 1 Kinesin motor domain Filament PF00038.21 PIK44994.1 - 0.00086 19.0 5.8 0.00086 19.0 5.8 1.9 2 0 0 2 2 2 1 Intermediate filament protein FAM184 PF15665.5 PIK44994.1 - 0.0011 18.8 7.6 0.0014 18.4 3.0 2.2 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B DUF4515 PF14988.6 PIK44994.1 - 0.012 15.5 7.9 0.012 15.5 7.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) Kinesin_assoc PF16183.5 PIK44994.1 - 0.021 15.0 2.9 0.086 13.0 2.9 2.0 1 1 0 1 1 1 0 Kinesin-associated PSI_PsaF PF02507.15 PIK44994.1 - 0.068 13.0 0.3 0.12 12.2 0.3 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III DUF3304 PF11745.8 PIK44994.1 - 0.12 12.8 0.3 0.24 11.8 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3304) Phage_Mu_Gam PF07352.12 PIK44994.1 - 0.42 10.5 15.8 0.37 10.7 10.4 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Tup_N PF08581.10 PIK44994.1 - 0.51 10.7 16.4 13 6.2 0.1 2.8 2 1 0 2 2 2 0 Tup N-terminal HIP1_clath_bdg PF16515.5 PIK44994.1 - 0.54 10.9 10.6 0.2 12.3 6.9 2.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Swi5 PF07061.11 PIK44994.1 - 3.2 7.9 9.6 1.4 9.1 5.2 2.3 2 0 0 2 2 2 0 Swi5 Kinesin PF00225.23 PIK44995.1 - 2.1e-42 145.2 0.0 2.6e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK44995.1 - 1.4e-23 83.5 0.0 1.9e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.6 PIK44995.1 - 0.02 15.2 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK44995.1 - 0.038 14.4 0.0 0.042 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF2791 PF10923.8 PIK44995.1 - 0.2 10.5 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) zf-C3HC4 PF00097.25 PIK44996.1 - 5.9e-09 35.7 9.0 5.9e-09 35.7 9.0 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK44996.1 - 1e-08 35.0 7.0 1e-08 35.0 7.0 2.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK44996.1 - 4.1e-07 29.7 9.6 4.1e-07 29.7 9.6 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK44996.1 - 6.7e-07 29.5 8.7 6.7e-07 29.5 8.7 3.7 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK44996.1 - 2.7e-06 27.4 8.8 2.7e-06 27.4 8.8 3.8 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK44996.1 - 2.4e-05 24.4 9.4 2.4e-05 24.4 9.4 4.8 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK44996.1 - 6.4e-05 22.7 13.7 6.4e-05 22.7 13.7 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK44996.1 - 0.00022 21.1 8.4 0.00022 21.1 8.4 3.5 3 0 0 3 3 3 1 zinc-RING finger domain DDE_Tnp_4 PF13359.6 PIK44997.1 - 3.3e-29 101.6 0.0 4.7e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK44997.1 - 6.5e-12 45.5 0.1 1.4e-11 44.4 0.1 1.5 1 1 0 1 1 1 1 Plant transposon protein MADF_DNA_bdg PF10545.9 PIK44999.1 - 0.00011 22.4 2.2 0.00011 22.4 2.2 2.4 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like G10 PF01125.17 PIK44999.1 - 0.025 14.4 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 G10 protein Ndc1_Nup PF09531.10 PIK44999.1 - 3.8 6.1 9.8 5 5.7 9.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.16 PIK45000.1 - 9.8e-12 44.5 0.0 1.1e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 PIK45001.1 - 2.6e-14 52.9 25.1 1.3e-12 47.4 9.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK45001.1 - 0.00061 18.8 11.6 0.0014 17.6 11.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter LapA_dom PF06305.11 PIK45001.1 - 4.5 7.2 5.6 2.3 8.1 2.4 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RT_RNaseH_2 PF17919.1 PIK45002.1 - 3.7e-37 126.4 0.0 5.6e-37 125.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45002.1 - 6.5e-31 106.7 0.0 9.6e-31 106.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK45002.1 - 0.00018 21.1 0.1 0.00051 19.6 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trp_dioxygenase PF03301.13 PIK45003.1 - 2.2e-55 188.4 0.2 2.7e-55 188.1 0.2 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase LRR_8 PF13855.6 PIK45004.1 - 6.3e-17 61.1 8.8 9.7e-11 41.3 3.5 4.1 2 2 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK45004.1 - 9.3e-09 35.3 0.2 0.0004 20.3 0.1 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK45004.1 - 1.6e-05 24.5 3.4 0.00038 20.0 0.8 2.3 1 1 0 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 PIK45004.1 - 0.00015 22.0 11.8 0.0063 16.9 2.6 4.7 2 2 4 6 6 6 3 Leucine Rich repeats (2 copies) LRRNT PF01462.18 PIK45004.1 - 0.19 11.4 7.5 0.046 13.4 3.9 1.9 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK45004.1 - 0.47 11.2 3.8 9.7 7.2 0.2 4.3 5 0 0 5 5 5 0 Leucine Rich Repeat ACC_central PF08326.12 PIK45005.1 - 1.2e-112 377.5 0.6 1.4e-112 377.3 0.6 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 PIK45005.1 - 6.9e-54 182.5 0.1 1.6e-53 181.4 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 PIK45005.1 - 5.8e-33 113.7 0.2 1.2e-32 112.7 0.2 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 PIK45005.1 - 1.5e-14 53.5 0.7 4.3e-13 48.9 0.2 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_carb_C PF02785.19 PIK45005.1 - 2.7e-14 53.2 0.0 1.7e-10 41.0 0.0 2.8 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 PIK45005.1 - 0.00025 20.7 0.0 0.00055 19.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 PIK45005.1 - 0.00072 19.6 0.1 0.002 18.2 0.1 1.8 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 PIK45005.1 - 0.003 17.3 0.1 0.023 14.5 0.0 2.5 3 0 0 3 3 3 1 Biotin-lipoyl like ATP-grasp PF02222.22 PIK45005.1 - 0.0035 16.9 0.1 0.007 16.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 PIK45005.1 - 0.011 15.5 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ACC_central PF08326.12 PIK45006.1 - 2e-120 403.2 1.6 2.4e-120 403.0 1.6 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 PIK45006.1 - 5.2e-13 48.5 0.0 7.1e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain DUF3767 PF12597.8 PIK45006.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) Carboxyl_trans PF01039.22 PIK45007.1 - 9.7e-131 436.8 0.0 1.5e-129 432.9 0.0 2.0 1 1 0 1 1 1 1 Carboxyl transferase domain Ephrin_rec_like PF07699.13 PIK45008.1 - 3e-13 49.3 8.1 3e-13 49.3 8.1 2.2 1 1 1 2 2 2 2 Putative ephrin-receptor like TNFR_c6 PF00020.18 PIK45008.1 - 0.017 15.5 5.7 0.26 11.7 0.8 2.8 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region Opy2 PF09463.10 PIK45008.1 - 1.5 9.2 6.9 0.6 10.5 1.1 2.3 2 0 0 2 2 2 0 Opy2 protein JAMP PF05571.12 PIK45008.1 - 1.8 8.1 5.8 4.7 6.8 5.8 1.7 1 1 0 1 1 1 0 JNK1/MAPK8-associated membrane protein Peptidase_C1 PF00112.23 PIK45009.1 - 1.2e-54 185.7 5.6 1.7e-54 185.2 5.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK45009.1 - 2.7e-10 40.5 3.3 2.7e-10 40.5 3.3 1.8 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK45009.1 - 5.5e-07 28.7 0.2 0.01 14.7 0.1 2.5 2 0 0 2 2 2 2 Peptidase C1-like family DUF1202 PF06717.11 PIK45009.1 - 0.14 11.5 1.1 0.23 10.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1202) Sulfotransfer_2 PF03567.14 PIK45010.1 - 3.8e-18 66.3 1.4 5.4e-18 65.8 1.3 1.4 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK45010.1 - 5.3e-05 22.8 0.1 7.7e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Sulfotransferase domain RT_RNaseH PF17917.1 PIK45011.1 - 8.7e-07 29.2 0.6 5.5e-06 26.6 0.6 2.0 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK45011.1 - 0.00067 19.6 0.4 0.0059 16.6 0.4 2.2 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PIP49_C PF12260.8 PIK45012.1 - 9.1e-29 100.4 0.0 1.2e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 DUF4647 PF15504.6 PIK45013.1 - 6.4e-16 58.5 5.4 9.4e-15 54.7 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4647) Transposase_20 PF02371.16 PIK45013.1 - 4.8 7.6 5.8 0.32 11.3 0.6 1.6 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family RT_RNaseH_2 PF17919.1 PIK45015.1 - 3.5e-33 113.6 0.0 8.6e-33 112.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45015.1 - 1.6e-32 111.9 0.0 2.9e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK45015.1 - 2.6e-24 86.0 0.1 5.7e-24 84.9 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3896 PF13035.6 PIK45015.1 - 0.068 13.3 0.8 0.18 12.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Hormone_recep PF00104.30 PIK45016.1 - 9e-07 28.7 0.0 9.5e-07 28.6 0.0 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor MSL2-CXC PF16682.5 PIK45017.1 - 3.7e-15 55.8 13.6 1.1e-14 54.3 13.6 1.8 1 0 0 1 1 1 1 CXC domain of E3 ubiquitin-protein ligase MSL2 TCR PF03638.15 PIK45017.1 - 0.18 12.2 18.2 0.69 10.3 18.2 1.9 1 1 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Metallothio PF00131.20 PIK45017.1 - 1.1 9.4 17.7 0.28 11.4 14.6 1.6 2 0 0 2 2 2 0 Metallothionein Carboxyl_trans PF01039.22 PIK45018.1 - 4.6e-155 517.0 0.0 5.6e-155 516.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Tctex-1 PF03645.13 PIK45019.1 - 5.7e-28 97.2 0.3 6.3e-28 97.0 0.3 1.0 1 0 0 1 1 1 1 Tctex-1 family zf-C3HC4 PF00097.25 PIK45020.1 - 1.8e-05 24.5 16.9 4e-05 23.4 16.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK45020.1 - 7e-05 22.6 16.8 0.00015 21.5 16.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK45020.1 - 0.00056 19.7 15.9 0.001 18.9 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK45020.1 - 0.00059 19.8 12.9 0.0015 18.5 12.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK45020.1 - 0.00097 19.3 16.7 0.0021 18.2 16.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 PIK45020.1 - 0.0037 17.0 4.8 0.0037 17.0 4.8 2.4 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 PIK45020.1 - 0.0054 16.7 13.4 0.012 15.5 13.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK45020.1 - 0.033 14.5 19.2 0.079 13.3 19.2 1.7 1 0 0 1 1 1 0 Ring finger domain CCDC50_N PF15295.6 PIK45020.1 - 0.035 14.3 34.6 0.68 10.1 27.5 3.1 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus Prok-RING_4 PF14447.6 PIK45020.1 - 0.12 12.2 18.0 0.21 11.4 15.1 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 SPOUT_MTase PF02590.17 PIK45020.1 - 1.7 8.6 7.4 7.6 6.5 7.4 2.1 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase MMR_HSR1_C PF08438.10 PIK45020.1 - 2 9.0 6.4 9.9 6.8 6.4 2.3 1 0 0 1 1 1 0 GTPase of unknown function C-terminal EF-hand_13 PF17958.1 PIK45021.1 - 1.6e-37 127.2 0.0 5.2e-37 125.5 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 PIK45021.1 - 5.8e-19 68.3 3.1 6.5e-18 64.9 0.1 3.9 4 3 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK45021.1 - 4.8e-05 22.7 0.3 0.001 18.5 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK45021.1 - 0.00018 21.2 6.3 0.0012 18.6 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 PIK45021.1 - 0.0014 18.0 0.1 0.0014 18.0 0.1 4.6 6 0 0 6 6 6 1 EF hand EF-hand_8 PF13833.6 PIK45021.1 - 0.018 14.9 3.2 0.61 10.0 0.0 3.7 3 0 0 3 3 3 0 EF-hand domain pair DUF4187 PF13821.6 PIK45021.1 - 0.065 13.0 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) SPARC_Ca_bdg PF10591.9 PIK45021.1 - 0.076 13.3 0.7 6.3 7.1 0.1 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Thiolase_N PF00108.23 PIK45022.1 - 8.7e-68 228.5 1.0 1.2e-67 228.0 1.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK45022.1 - 4.4e-44 149.1 1.0 1e-43 147.9 1.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 PIK45022.1 - 9.6e-06 25.4 1.1 3.3e-05 23.6 0.6 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain DAGAT PF03982.13 PIK45023.1 - 1e-67 228.1 0.0 1.3e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase ITAM_Cys-rich PF10538.9 PIK45023.1 - 2.9 7.7 6.5 2.1 8.1 0.4 3.0 3 0 0 3 3 3 0 Immunoreceptor tyrosine-based activation motif DAGAT PF03982.13 PIK45024.1 - 4.4e-103 344.3 0.1 5.2e-103 344.0 0.1 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Ig_2 PF13895.6 PIK45025.1 - 2.8e-06 27.6 0.1 0.00036 20.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK45025.1 - 8.8e-05 23.0 0.1 0.00085 19.9 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK45025.1 - 0.035 14.3 0.1 0.23 11.7 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK45025.1 - 0.092 12.9 0.1 0.56 10.4 0.1 2.3 1 1 1 2 2 2 0 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK45026.1 - 2.1e-05 24.5 0.2 3.7e-05 23.7 0.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 PIK45026.1 - 0.0019 18.8 0.2 0.0019 18.8 0.2 2.3 2 1 1 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK45026.1 - 0.002 18.4 0.1 0.0049 17.2 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK45026.1 - 0.0039 17.4 0.6 0.2 11.8 0.2 3.1 2 1 1 3 3 3 1 Immunoglobulin V-set domain DUF5305 PF17231.2 PIK45026.1 - 0.018 14.5 0.1 0.03 13.7 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF4448 PF14610.6 PIK45026.1 - 0.026 14.3 0.1 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 PIK45026.1 - 0.031 15.1 0.0 0.065 14.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_2 PF13895.6 PIK45027.1 - 9.3e-05 22.7 0.1 0.00035 20.9 0.1 2.0 1 0 0 1 1 1 1 Immunoglobulin domain TMEM154 PF15102.6 PIK45027.1 - 0.00016 21.6 0.6 0.00036 20.4 0.6 1.6 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.12 PIK45027.1 - 0.00036 20.4 0.3 0.0008 19.3 0.3 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Ig_3 PF13927.6 PIK45027.1 - 0.0053 17.3 0.2 0.0053 17.3 0.2 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Sigma_reg_N PF13800.6 PIK45027.1 - 0.015 15.6 2.3 0.016 15.5 0.2 2.3 2 1 0 2 2 1 0 Sigma factor regulator N-terminal Tmemb_9 PF05434.11 PIK45027.1 - 0.037 13.9 0.1 0.079 12.9 0.1 1.6 1 0 0 1 1 1 0 TMEM9 DUF2615 PF11027.8 PIK45027.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Syndecan PF01034.20 PIK45027.1 - 0.07 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain Cadherin_C_2 PF16492.5 PIK45027.1 - 0.088 13.6 0.0 0.24 12.2 0.0 1.7 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal I-set PF07679.16 PIK45027.1 - 0.3 11.2 4.4 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.17 PIK45027.1 - 0.39 10.9 5.6 0.3 11.3 0.3 2.9 2 1 0 3 3 3 0 Immunoglobulin V-set domain ATAD4 PF15321.6 PIK45027.1 - 1.9 9.9 6.6 12 7.3 6.6 2.2 1 1 0 1 1 1 0 ATPase family AAA domain containing 4 Orf78 PF06024.12 PIK45027.1 - 2.9 8.2 5.0 1.1 9.6 1.5 2.1 1 1 1 2 2 2 0 Orf78 (ac78) TMEM154 PF15102.6 PIK45028.1 - 0.00017 21.5 2.2 0.00038 20.4 2.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family Ig_2 PF13895.6 PIK45028.1 - 0.0062 16.8 0.1 0.017 15.5 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain STAC2_u1 PF16664.5 PIK45028.1 - 0.032 14.7 1.1 0.091 13.2 1.1 1.7 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Shisa PF13908.6 PIK45028.1 - 0.033 14.4 1.8 0.066 13.4 1.7 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 PIK45028.1 - 0.035 15.1 0.1 0.13 13.2 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 PIK45028.1 - 0.061 14.2 0.0 0.15 12.9 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 PIK45028.1 - 0.081 12.5 1.2 0.19 11.3 1.2 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family Insulin_TMD PF17870.1 PIK45028.1 - 0.15 12.1 2.8 0.31 11.1 2.8 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RVT_1 PF00078.27 PIK45030.1 - 7.4e-18 64.9 0.6 3.1e-17 62.8 0.4 2.1 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SET PF00856.28 PIK45032.1 - 9.4e-05 22.9 2.6 0.0076 16.7 0.0 2.3 2 0 0 2 2 2 2 SET domain TylF PF05711.11 PIK45032.1 - 0.088 12.1 0.3 0.17 11.2 0.2 1.4 1 1 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) PPO1_DWL PF12142.8 PIK45032.1 - 0.15 11.9 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Polyphenol oxidase middle domain Ribosomal_S7e PF01251.18 PIK45033.1 - 2e-84 281.9 8.7 2.3e-84 281.7 8.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e AlbA_2 PF04326.14 PIK45033.1 - 0.1 12.9 2.7 2 8.7 0.4 2.2 1 1 1 2 2 2 0 Putative DNA-binding domain RNase_H PF00075.24 PIK45034.1 - 3.9e-44 150.3 0.2 5.4e-44 149.8 0.2 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 PIK45034.1 - 4.3e-08 33.0 0.1 1.2e-07 31.6 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase-like Skp1_POZ PF03931.15 PIK45035.1 - 6.3e-11 42.3 0.0 1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain PTAC PF06130.12 PIK45035.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphate propanoyltransferase MFS_2 PF13347.6 PIK45037.1 - 3.1e-91 306.1 24.2 2.3e-63 214.3 9.9 2.0 1 1 1 2 2 2 2 MFS/sugar transport protein E1-E2_ATPase PF00122.20 PIK45037.1 - 0.099 12.2 4.6 2.5 7.6 0.2 2.6 1 1 0 2 2 2 0 E1-E2 ATPase Fibrinogen_C PF00147.18 PIK45038.1 - 3.4e-60 203.6 3.6 8e-60 202.4 3.6 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK45038.1 - 0.00026 21.1 7.1 0.00026 21.1 7.1 2.4 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK45038.1 - 0.0011 18.9 4.5 0.0038 17.1 4.5 2.0 1 0 0 1 1 1 1 TILa domain EGF_MSP1_1 PF12946.7 PIK45038.1 - 0.11 12.6 5.0 0.3 11.2 5.0 1.8 1 0 0 1 1 1 0 MSP1 EGF domain 1 Macoilin PF09726.9 PIK45038.1 - 0.63 8.5 20.2 0.8 8.2 20.2 1.1 1 0 0 1 1 1 0 Macoilin family Sushi PF00084.20 PIK45039.1 - 3e-14 53.3 6.4 1.1e-08 35.5 0.6 2.9 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) Lectin_C PF00059.21 PIK45039.1 - 3.7e-05 24.4 0.9 0.00011 22.9 0.0 2.2 2 1 1 3 3 3 1 Lectin C-type domain 7tm_1 PF00001.21 PIK45041.1 - 2e-28 99.4 7.2 2.7e-28 99.0 7.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK45041.1 - 1.9e-08 34.3 22.5 1.9e-08 34.3 22.5 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ASFV_J13L PF05568.11 PIK45041.1 - 0.26 11.0 4.3 0.61 9.8 4.3 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein FixQ PF05545.11 PIK45041.1 - 3 7.9 4.9 0.77 9.8 0.4 2.4 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ SNARE PF05739.19 PIK45042.1 - 9.1e-07 28.8 0.2 1.8e-06 27.8 0.2 1.4 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 PIK45043.1 - 0.00056 19.6 4.7 0.00081 19.1 4.7 1.3 1 0 0 1 1 1 1 Syntaxin Laminin_II PF06009.12 PIK45043.1 - 0.022 14.8 0.6 0.032 14.3 0.6 1.2 1 0 0 1 1 1 0 Laminin Domain II DUF4239 PF14023.6 PIK45043.1 - 0.052 13.3 0.4 0.061 13.1 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) BLOC1_2 PF10046.9 PIK45043.1 - 0.13 12.5 6.2 3.1 8.1 4.3 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 PIK45043.1 - 0.37 10.8 3.2 0.58 10.2 3.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.8 PIK45043.1 - 1 8.5 4.9 1.2 8.3 4.9 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein SNARE PF05739.19 PIK45043.1 - 9.7 6.3 7.6 3.7 7.6 0.2 2.5 3 0 0 3 3 3 0 SNARE domain SNARE PF05739.19 PIK45044.1 - 1e-19 70.2 1.5 3e-19 68.8 1.5 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 PIK45044.1 - 2.6e-19 69.4 7.1 6.9e-18 64.9 0.9 2.1 2 0 0 2 2 2 2 Syntaxin-like protein Syntaxin PF00804.25 PIK45044.1 - 4e-09 36.5 8.0 1.2e-05 25.1 0.9 2.4 2 0 0 2 2 2 2 Syntaxin Synaptobrevin PF00957.21 PIK45044.1 - 0.0014 18.3 3.3 0.0039 16.9 3.3 1.7 1 0 0 1 1 1 1 Synaptobrevin FliJ PF02050.16 PIK45044.1 - 0.019 15.2 4.4 0.019 15.2 4.4 2.2 2 1 0 2 2 2 0 Flagellar FliJ protein Herpes_US9 PF06072.11 PIK45044.1 - 0.034 14.0 0.3 0.069 13.0 0.3 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 TMCO5 PF14992.6 PIK45044.1 - 0.14 11.7 8.7 0.4 10.2 8.7 1.7 1 1 0 1 1 1 0 TMCO5 family DUF5345 PF17280.2 PIK45044.1 - 0.17 11.9 0.3 0.17 11.9 0.3 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5345) DUF2207 PF09972.9 PIK45044.1 - 0.22 10.3 2.2 0.35 9.6 2.2 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Prominin PF05478.11 PIK45044.1 - 0.42 8.5 8.8 0.88 7.4 8.8 1.4 1 1 0 1 1 1 0 Prominin Hamartin PF04388.12 PIK45044.1 - 0.5 9.0 8.4 0.59 8.7 8.4 1.0 1 0 0 1 1 1 0 Hamartin protein MCU PF04678.13 PIK45044.1 - 1.2 9.2 7.5 1.7 8.8 1.4 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Vma12 PF11712.8 PIK45044.1 - 1.3 9.1 3.9 5.3 7.1 3.9 2.1 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1043 PF06295.12 PIK45044.1 - 3 7.9 7.7 6 6.9 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) THOC7 PF05615.13 PIK45044.1 - 4.4 7.6 11.5 1.1 9.5 3.5 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 Orf78 PF06024.12 PIK45044.1 - 5.9 7.2 6.9 0.73 10.2 1.4 2.2 2 1 0 2 2 2 0 Orf78 (ac78) Wzz PF02706.15 PIK45044.1 - 7.5 6.9 10.2 9 6.7 0.3 2.9 3 1 0 3 3 3 0 Chain length determinant protein Stathmin PF00836.19 PIK45045.1 - 2e-14 53.7 24.9 2e-14 53.7 24.9 1.9 2 0 0 2 2 2 1 Stathmin family DUF1081 PF06448.11 PIK45045.1 - 0.93 9.9 6.9 2.6 8.4 6.9 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1081) Pox_VLTF3 PF04947.14 PIK45045.1 - 7.9 6.2 10.2 1.6 8.4 4.6 2.1 1 1 1 2 2 2 0 Poxvirus Late Transcription Factor VLTF3 like WSC PF01822.19 PIK45046.1 - 8.4e-16 57.9 9.4 8.4e-16 57.9 9.4 2.9 3 1 0 3 3 3 1 WSC domain SRCR_2 PF15494.6 PIK45046.1 - 0.0023 18.4 0.6 0.0045 17.5 0.6 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK45046.1 - 0.0024 18.3 1.3 0.0065 17.0 1.3 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK45046.1 - 0.079 13.5 1.0 0.3 11.6 0.7 2.1 1 1 1 2 2 2 0 Hepsin, SRCR domain YecR PF13992.6 PIK45046.1 - 0.2 11.9 0.1 0.2 11.9 0.1 3.2 1 1 3 4 4 4 0 YecR-like lipoprotein WSC PF01822.19 PIK45047.1 - 1.7e-16 60.2 9.4 3.8e-16 59.1 9.4 1.6 1 0 0 1 1 1 1 WSC domain SRCR PF00530.18 PIK45047.1 - 8.1e-05 23.1 0.4 0.00022 21.7 0.4 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain CUB PF00431.20 PIK45047.1 - 0.00064 20.0 0.1 0.0026 18.1 0.0 2.0 2 0 0 2 2 2 1 CUB domain SRCR_2 PF15494.6 PIK45047.1 - 0.1 13.2 0.9 0.24 11.9 0.0 2.0 2 0 0 2 2 2 0 Scavenger receptor cysteine-rich domain BSD PF03909.17 PIK45048.1 - 8.2e-17 61.0 0.1 1.6e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 BSD domain PHTB1_C PF14728.6 PIK45049.1 - 3.2e-134 447.8 0.0 4e-134 447.4 0.0 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus PHTB1_N PF14727.6 PIK45049.1 - 6.9e-77 259.5 0.0 1.1e-76 258.8 0.0 1.3 1 0 0 1 1 1 1 PTHB1 N-terminus SAM_2 PF07647.17 PIK45050.1 - 5.2e-07 29.7 0.1 9.1e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK45050.1 - 9.4e-07 29.2 0.1 1.5e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CobN-Mg_chel PF02514.16 PIK45051.1 - 0.0032 15.3 0.3 0.0035 15.2 0.3 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase OEP PF02321.18 PIK45051.1 - 0.78 9.5 10.8 0.93 9.3 10.8 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein PDZ PF00595.24 PIK45052.1 - 1.9e-12 47.3 0.3 3.8e-12 46.4 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK45052.1 - 0.00011 22.0 0.8 0.00017 21.4 0.1 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK45052.1 - 0.0029 17.9 0.1 0.0054 17.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Glyco_transf_54 PF04666.13 PIK45052.1 - 0.19 10.6 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region 7tm_1 PF00001.21 PIK45053.1 - 1.8e-21 76.7 6.7 2.4e-21 76.3 6.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ApoL PF05461.11 PIK45054.1 - 1.5e-06 27.8 0.1 2.3e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Apolipoprotein L DUF4781 PF16013.5 PIK45054.1 - 0.037 12.8 0.7 0.1 11.4 0.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4781) DUF1445 PF07286.12 PIK45055.1 - 6.9e-50 168.7 0.0 1.1e-49 168.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) DUF4392 PF14336.6 PIK45055.1 - 0.0032 17.0 0.0 0.33 10.4 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4392) 7tm_1 PF00001.21 PIK45056.1 - 2e-32 112.6 15.6 3.1e-32 111.9 15.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK45057.1 - 6.3e-33 114.2 14.9 8.7e-33 113.7 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Acyl-CoA_dh_1 PF00441.24 PIK45058.1 - 3.1e-44 150.8 0.9 3.2e-38 131.3 0.2 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK45058.1 - 6.6e-27 93.6 0.1 1.4e-26 92.5 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK45058.1 - 1.7e-20 73.7 0.0 4.6e-20 72.4 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK45058.1 - 1.4e-16 61.0 0.0 7.9e-14 52.1 0.0 3.1 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1974 PF09317.11 PIK45058.1 - 0.074 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) Ribosomal_L18A PF01775.17 PIK45059.1 - 8.3e-56 187.3 0.8 9.4e-56 187.1 0.8 1.0 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A PAS PF00989.25 PIK45059.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold Xpo1 PF08389.12 PIK45060.1 - 2.1e-41 141.5 0.9 2.1e-41 141.5 0.9 3.4 4 0 0 4 4 4 1 Exportin 1-like protein BP28CT PF08146.12 PIK45060.1 - 0.00025 20.9 0.1 0.13 12.1 0.0 3.0 2 0 0 2 2 2 2 BP28CT (NUC211) domain AAA_lid_7 PF17867.1 PIK45060.1 - 0.014 15.6 0.4 23 5.3 0.2 4.0 3 1 0 3 3 3 0 Midasin AAA lid domain HEAT PF02985.22 PIK45060.1 - 0.088 13.1 0.1 9 6.9 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat IBN_N PF03810.19 PIK45060.1 - 1.4 8.8 4.5 1.7 8.6 0.2 3.4 4 0 0 4 4 4 0 Importin-beta N-terminal domain Pkinase PF00069.25 PIK45062.1 - 6.2e-38 130.7 0.0 1.2e-37 129.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45062.1 - 1.4e-27 96.7 0.1 3.6e-27 95.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase TBK1_CCD1 PF18394.1 PIK45062.1 - 4.3e-19 69.1 8.7 4.6e-18 65.7 5.5 2.4 1 1 1 2 2 2 2 TANK-binding kinase 1 coiled-coil domain 1 TBK1_ULD PF18396.1 PIK45062.1 - 5.6e-17 61.5 0.1 1.3e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_fungal PF17667.1 PIK45062.1 - 3.4e-05 22.8 0.0 8.9e-05 21.4 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK45062.1 - 4.5e-05 22.9 0.0 0.00013 21.3 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 PIK45062.1 - 0.011 15.7 0.2 4.7 7.1 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family B PF02216.16 PIK45063.1 - 1.3e-11 44.3 0.0 0.32 11.0 0.0 9.4 1 1 9 10 10 10 2 B domain Neuropeptide_S PF14993.6 PIK45063.1 - 1.4e-08 34.4 18.4 25 4.8 0.0 9.7 1 1 9 10 10 10 8 Neuropeptide S precursor protein VP_N-CPKC PF11475.8 PIK45063.1 - 0.12 12.3 40.0 57 3.8 0.2 10.0 10 0 0 10 10 10 0 Virion protein N terminal domain Sigma_1s PF02454.16 PIK45063.1 - 0.61 10.1 3.4 10 6.1 0.4 3.4 2 1 1 3 3 3 0 Sigma 1s protein ANF_receptor PF01094.28 PIK45064.1 - 3.6e-13 49.3 0.1 4.4e-13 49.1 0.1 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region SSF PF00474.17 PIK45065.1 - 7.1e-20 71.2 15.3 9.5e-20 70.8 15.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family OAD_gamma PF04277.13 PIK45065.1 - 1.8 9.2 7.6 7.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain LapA_dom PF06305.11 PIK45065.1 - 2.6 7.9 5.1 3.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain NdhL PF10716.9 PIK45065.1 - 5.6 7.0 9.6 0.16 12.0 1.1 2.6 2 1 0 3 3 3 0 NADH dehydrogenase transmembrane subunit SSF PF00474.17 PIK45066.1 - 3.4e-16 59.1 4.1 3.4e-16 59.1 4.1 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family DUF3792 PF12670.7 PIK45066.1 - 0.00033 20.8 6.4 0.00033 20.8 6.4 3.7 5 0 0 5 5 5 1 Protein of unknown function (DUF3792) DUF2207 PF09972.9 PIK45066.1 - 0.012 14.4 3.4 1.3 7.7 1.1 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Colicin_V PF02674.16 PIK45066.1 - 0.83 9.6 13.9 0.047 13.7 4.0 3.3 2 1 1 3 3 3 0 Colicin V production protein DUF4233 PF14017.6 PIK45066.1 - 1.2 9.5 9.0 3.7 8.0 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4233) 5TM-5TMR_LYT PF07694.12 PIK45066.1 - 7.9 6.0 20.3 0.094 12.2 10.7 2.6 3 1 0 3 3 3 0 5TMR of 5TMR-LYT SSF PF00474.17 PIK45067.1 - 9.7e-22 77.4 15.5 1.3e-21 77.0 15.5 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family OAD_gamma PF04277.13 PIK45067.1 - 2.8 8.6 8.3 8 7.1 0.1 2.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NdhL PF10716.9 PIK45067.1 - 8.3 6.4 10.3 0.27 11.2 1.8 2.7 2 1 0 3 3 3 0 NADH dehydrogenase transmembrane subunit TPR_1 PF00515.28 PIK45068.1 - 1.2e-17 62.9 0.0 3.5e-09 36.1 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45068.1 - 1.1e-15 56.3 0.3 2.4e-05 24.1 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45068.1 - 1.5e-13 49.8 0.0 1.1e-05 25.3 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45068.1 - 5.8e-12 45.1 0.0 0.0043 16.7 0.0 3.2 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.6 PIK45068.1 - 7.3e-10 39.3 0.1 1.2e-05 25.8 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK45068.1 - 1.4e-09 38.1 0.1 5.5e-07 29.8 0.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK45068.1 - 2.2e-08 33.9 0.0 0.018 15.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK45068.1 - 5.5e-08 33.2 0.0 3.8e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK45068.1 - 2.8e-06 27.7 0.2 0.68 10.9 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK45068.1 - 0.00036 20.0 0.1 0.052 12.9 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 PIK45068.1 - 0.00065 19.5 0.1 0.33 11.1 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK45068.1 - 0.003 17.8 0.0 0.065 13.5 0.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 PIK45068.1 - 0.0036 17.1 0.9 3 7.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK45068.1 - 0.037 14.2 0.0 0.64 10.2 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF1736 PF08409.11 PIK45069.1 - 1.9e-31 107.8 2.6 5.4e-31 106.4 2.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_11 PF13414.6 PIK45069.1 - 6.9e-20 70.4 7.8 0.00019 21.0 0.2 4.3 1 1 3 4 4 4 4 TPR repeat TPR_17 PF13431.6 PIK45069.1 - 1.7e-16 59.3 10.6 0.00073 19.7 0.2 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK45069.1 - 4.6e-15 54.7 13.3 1.5e-06 27.7 0.2 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45069.1 - 2.7e-14 52.0 12.8 9.7e-05 22.2 0.4 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45069.1 - 1.7e-10 40.2 9.3 0.01 16.0 0.4 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK45069.1 - 2.3e-09 37.7 6.0 0.0012 19.5 1.0 3.4 2 1 1 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK45069.1 - 6.3e-09 36.0 7.7 0.00017 21.8 4.5 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK45069.1 - 1.4e-08 34.8 2.6 0.0087 16.8 0.2 4.2 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK45069.1 - 1.7e-07 31.6 10.9 7.8e-05 23.1 2.9 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK45069.1 - 3.4e-05 23.5 14.3 0.056 13.3 3.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK45069.1 - 0.0019 17.5 1.2 0.0028 16.9 1.2 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK45069.1 - 0.0022 18.1 1.0 0.0087 16.2 0.2 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK45069.1 - 0.027 14.5 0.9 0.079 13.0 0.7 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_7 PF13176.6 PIK45069.1 - 0.032 14.3 7.4 4.9 7.4 0.1 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK45069.1 - 0.049 14.3 1.6 7.2 7.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 PIK45069.1 - 1.2 9.3 5.1 20 5.3 0.2 3.1 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain YfhO PF09586.10 PIK45069.1 - 6.6 4.8 14.5 0.1 10.8 7.1 1.6 2 0 0 2 2 2 0 Bacterial membrane protein YfhO Thioredoxin_7 PF13899.6 PIK45070.1 - 1e-16 60.8 0.0 2.2e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 PIK45070.1 - 6.7e-14 51.9 0.1 1.6e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 UBX domain Thioredoxin_2 PF13098.6 PIK45070.1 - 3.8e-05 24.1 0.3 0.00013 22.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain UIM PF02809.20 PIK45070.1 - 1.2 9.2 3.2 3 7.9 3.2 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4551 PF15087.6 PIK45070.1 - 1.9 7.2 6.7 0.16 10.8 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Pyrid_oxidase_2 PF13883.6 PIK45071.1 - 2.3e-34 118.8 0.0 2.6e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Lamp PF01299.17 PIK45072.1 - 0.15 11.9 0.0 0.22 11.4 0.0 1.4 1 1 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) rve PF00665.26 PIK45073.1 - 3e-24 85.5 0.0 4.7e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK45073.1 - 6.9e-09 35.4 0.1 2.1e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK45073.1 - 0.0017 18.4 0.0 0.0037 17.3 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Methyltransf_25 PF13649.6 PIK45074.1 - 1.1e-10 42.1 0.0 1.8e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK45074.1 - 1e-08 35.7 0.0 1.6e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK45074.1 - 1.4e-06 27.9 0.0 1.8e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 PIK45074.1 - 3.5e-06 27.7 0.1 6.5e-06 26.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK45074.1 - 3.7e-06 26.8 0.1 5.3e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK45074.1 - 9.2e-06 25.6 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK45074.1 - 3.2e-05 23.5 0.0 4.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 PIK45074.1 - 0.00096 18.6 1.6 0.0015 18.0 0.1 1.8 1 1 1 2 2 2 1 Tellurite resistance protein TehB MetW PF07021.12 PIK45074.1 - 0.0039 16.8 0.1 0.0051 16.4 0.1 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 PIK45074.1 - 0.1 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain PAD_M PF08527.10 PIK45075.1 - 0.12 12.0 0.5 0.44 10.2 0.1 1.8 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain Ig_3 PF13927.6 PIK45076.1 - 3.7e-10 40.3 6.5 4e-07 30.6 0.3 3.5 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK45076.1 - 3.9e-09 36.4 1.5 8.2e-05 22.6 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK45076.1 - 7.6e-07 29.2 5.0 2.1e-05 24.6 0.2 3.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK45076.1 - 9.1e-05 22.7 0.3 9.1e-05 22.7 0.3 3.9 3 2 1 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK45076.1 - 0.00029 20.9 0.9 0.0062 16.6 0.1 2.9 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK45076.1 - 0.00071 19.7 1.1 0.006 16.7 0.3 2.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK45076.1 - 0.012 16.0 6.4 0.034 14.5 0.4 3.4 3 1 0 3 3 3 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK45076.1 - 0.13 12.3 0.0 0.37 10.9 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Invasin_D3 PF09134.10 PIK45077.1 - 0.002 18.4 0.1 0.44 10.9 0.0 2.6 2 0 0 2 2 2 2 Invasin, domain 3 I-set PF07679.16 PIK45077.1 - 0.015 15.3 0.1 3 8.0 0.0 3.4 4 0 0 4 4 4 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK45077.1 - 0.037 14.6 2.2 78 4.0 0.0 4.3 3 2 2 5 5 5 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK45077.1 - 0.052 13.6 0.5 0.72 10.0 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain rve PF00665.26 PIK45078.1 - 2.7e-15 56.6 0.0 5.5e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK45078.1 - 1.3e-05 24.9 0.1 2.9e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DTHCT PF08070.11 PIK45078.1 - 0.054 14.2 0.9 0.054 14.2 0.9 1.8 2 0 0 2 2 2 0 DTHCT (NUC029) region DUF3347 PF11827.8 PIK45079.1 - 0.62 10.2 4.2 1.4 9.1 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) HEAT PF02985.22 PIK45081.1 - 5.2e-08 32.5 2.0 0.002 18.2 0.1 4.0 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 PIK45081.1 - 3.8e-06 27.2 0.0 0.12 12.8 0.0 2.9 2 0 0 2 2 2 2 HEAT repeats Cohesin_HEAT PF12765.7 PIK45081.1 - 1e-05 25.7 0.4 0.45 10.9 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 PIK45081.1 - 0.0012 18.9 5.4 0.26 11.3 0.2 4.0 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HBS1_N PF08938.10 PIK45081.1 - 0.035 14.4 1.0 0.09 13.1 1.0 1.6 1 0 0 1 1 1 0 HBS1 N-terminus Cnd3 PF12719.7 PIK45081.1 - 0.043 13.0 1.1 25 3.9 0.1 3.3 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 PIK45081.1 - 0.15 12.2 2.9 19 5.5 0.0 3.8 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 RhoGAP PF00620.27 PIK45082.1 - 1.2e-13 51.1 0.0 1.3e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain RhoGAP-FF1 PF16512.5 PIK45083.1 - 1.8e-20 73.4 6.0 1.8e-20 73.4 6.0 2.7 2 0 0 2 2 2 1 p190-A and -B Rho GAPs FF domain FF PF01846.19 PIK45083.1 - 8.3e-09 35.5 1.7 0.079 13.2 0.2 3.8 3 0 0 3 3 3 3 FF domain Ras PF00071.22 PIK45083.1 - 1e-07 31.7 0.1 1.1e-06 28.3 0.1 2.4 2 0 0 2 2 2 1 Ras family NOG1 PF06858.14 PIK45083.1 - 0.0012 18.6 0.1 0.0054 16.5 0.1 2.2 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) DUF1818 PF08848.11 PIK45083.1 - 0.002 18.2 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1818) rve PF00665.26 PIK45084.1 - 2.5e-16 59.9 0.1 1e-14 54.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK45084.1 - 0.0001 22.0 0.1 0.001 18.8 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK45085.1 - 1.4e-25 89.3 0.0 1.7e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45085.1 - 1.4e-14 54.2 0.0 1.9e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK45086.1 - 1.1e-07 31.6 0.0 2.1e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NAD_binding_8 PF13450.6 PIK45087.1 - 8e-13 48.4 0.4 1.2e-12 47.9 0.4 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK45087.1 - 1.1e-05 25.2 0.4 1.2e-05 25.1 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK45087.1 - 0.00027 20.3 0.1 0.0003 20.1 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 PIK45087.1 - 0.00066 19.1 0.0 0.00079 18.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 PIK45087.1 - 0.023 14.7 0.2 0.035 14.1 0.2 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 PIK45087.1 - 0.11 11.3 0.1 0.14 11.0 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 PIK45087.1 - 0.18 12.4 0.7 0.5 11.0 0.5 1.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase LRR_9 PF14580.6 PIK45088.1 - 7.7e-19 67.9 2.0 5.1e-14 52.2 0.2 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 PIK45088.1 - 1.4e-12 47.6 18.2 6.3e-05 23.3 0.3 5.8 2 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK45088.1 - 4.1e-11 42.5 9.0 8.6e-06 25.4 0.5 3.6 2 1 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 PIK45088.1 - 0.0012 18.7 9.4 0.22 11.7 0.0 5.9 6 0 0 6 6 6 1 Leucine Rich repeat G-gamma PF00631.22 PIK45089.1 - 2.6e-14 53.0 1.3 5.3e-14 52.0 0.0 2.2 2 0 0 2 2 2 1 GGL domain Wbp11 PF09429.10 PIK45089.1 - 0.056 13.8 1.3 0.056 13.8 1.3 2.6 3 0 0 3 3 3 0 WW domain binding protein 11 FCH PF00611.23 PIK45089.1 - 0.099 12.9 2.1 0.11 12.8 0.3 1.9 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain CP12 PF02672.15 PIK45089.1 - 0.52 11.1 6.4 0.51 11.1 0.3 2.5 3 0 0 3 3 3 0 CP12 domain HIP1_clath_bdg PF16515.5 PIK45089.1 - 0.8 10.4 13.0 2.9 8.6 7.7 2.5 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exostosin PF03016.15 PIK45090.1 - 2e-12 46.9 0.0 2.5e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Integrase_H2C2 PF17921.1 PIK45091.1 - 9.8e-11 41.6 0.6 1.8e-10 40.7 0.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK45091.1 - 1.9e-08 34.5 0.0 3.5e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK45091.1 - 0.0042 16.8 0.0 0.0097 15.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK45091.1 - 0.097 12.9 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger RVT_1 PF00078.27 PIK45092.1 - 3e-15 56.4 0.0 5.3e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK45092.1 - 0.034 14.3 0.0 0.053 13.7 0.0 1.3 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Exo_endo_phos_2 PF14529.6 PIK45093.1 - 8.2e-09 35.3 0.0 1.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK45093.1 - 0.081 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family HTH_33 PF13592.6 PIK45094.1 - 0.035 13.7 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_C28 PF05408.11 PIK45094.1 - 0.15 11.7 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Foot-and-mouth virus L-proteinase DNA_gyraseA_C PF03989.13 PIK45094.1 - 0.16 11.5 0.5 3.2 7.3 0.1 2.6 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller RT_RNaseH_2 PF17919.1 PIK45095.1 - 5.8e-29 100.1 0.1 1.2e-28 99.1 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45095.1 - 5.7e-25 87.6 0.1 1.2e-24 86.5 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK45095.1 - 2.9e-19 68.9 0.0 7.7e-19 67.6 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK45095.1 - 3.4e-19 69.2 0.0 7.8e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK45095.1 - 3.3e-16 59.5 0.5 4.4e-11 42.7 0.0 2.8 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK45095.1 - 1.7e-08 34.9 1.0 5.4e-08 33.3 0.0 2.4 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK45095.1 - 1.3e-05 25.8 0.0 3.2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 PIK45095.1 - 0.00072 19.3 0.1 0.0019 18.0 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK45095.1 - 0.047 13.9 1.1 0.11 12.8 0.0 2.3 2 0 0 2 2 2 0 H2C2 zinc finger HisG PF01634.18 PIK45096.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 ATP phosphoribosyltransferase PrmA PF06325.13 PIK45097.1 - 2.6e-09 36.9 0.1 3.7e-09 36.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 PIK45097.1 - 7e-08 33.1 0.1 1.5e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK45097.1 - 9.2e-06 25.3 0.1 1.5e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 PIK45097.1 - 8.8e-05 22.3 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_18 PF12847.7 PIK45097.1 - 9.6e-05 22.4 0.1 0.00015 21.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK45097.1 - 0.0002 21.0 0.0 0.00031 20.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TPR_14 PF13428.6 PIK45097.1 - 0.00025 21.6 0.0 0.028 15.2 0.0 3.1 3 1 1 4 4 2 1 Tetratricopeptide repeat Methyltransf_11 PF08241.12 PIK45097.1 - 0.00027 21.5 0.0 0.00057 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK45097.1 - 0.00042 20.1 0.0 0.00079 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TPR_2 PF07719.17 PIK45097.1 - 0.00046 20.1 0.0 0.078 13.1 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat Methyltransf_23 PF13489.6 PIK45097.1 - 0.00098 19.0 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 PIK45097.1 - 0.0015 18.6 0.1 0.0028 17.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK45097.1 - 0.0016 19.1 0.0 0.0049 17.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain TPR_7 PF13176.6 PIK45097.1 - 0.0019 18.1 0.0 1.4 9.1 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45097.1 - 0.0024 17.9 0.0 1 9.8 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45097.1 - 0.004 16.8 0.0 1.4 8.6 0.0 2.8 1 1 1 2 2 2 1 TPR repeat RrnaAD PF00398.20 PIK45097.1 - 0.0054 15.8 0.0 0.0073 15.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TPR_1 PF00515.28 PIK45097.1 - 0.0069 16.2 0.0 1.1 9.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK45097.1 - 0.007 16.6 0.0 0.048 13.9 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 CMAS PF02353.20 PIK45097.1 - 0.017 14.5 0.3 0.054 12.8 0.0 1.8 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase TPR_12 PF13424.6 PIK45097.1 - 0.037 14.3 0.1 1.6 9.1 0.0 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat DOT1 PF08123.13 PIK45097.1 - 0.045 13.3 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 TPR_9 PF13371.6 PIK45097.1 - 0.053 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat PCMT PF01135.19 PIK45097.1 - 0.08 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 PIK45097.1 - 0.092 12.5 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF938) Methyltransf_3 PF01596.17 PIK45097.1 - 0.13 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase ANAPC5 PF12862.7 PIK45097.1 - 0.39 10.8 3.4 1.3 9.1 1.5 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 MIEAP PF16026.5 PIK45098.1 - 1.7e-48 165.5 0.2 4.5e-48 164.1 0.0 1.7 2 0 0 2 2 2 1 Mitochondria-eating protein DUF4378 PF14309.6 PIK45098.1 - 0.006 17.0 0.4 0.014 15.7 0.1 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4378) MbeD_MobD PF04899.12 PIK45098.1 - 0.075 13.2 0.2 0.27 11.4 0.2 2.0 1 0 0 1 1 1 0 MbeD/MobD like zf-C4H2 PF10146.9 PIK45098.1 - 0.11 12.8 0.7 0.23 11.8 0.6 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein DHR10 PF18595.1 PIK45098.1 - 1.1 9.3 6.9 0.82 9.7 4.8 1.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Myb_DNA-bind_2 PF08914.11 PIK45099.1 - 5.4e-19 68.1 0.5 1.4e-18 66.8 0.5 1.8 1 0 0 1 1 1 1 Rap1 Myb domain BRCT_2 PF16589.5 PIK45099.1 - 1.5e-13 50.9 0.0 4e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 PIK45099.1 - 0.00022 21.4 0.2 0.016 15.4 0.0 2.7 2 1 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.8 PIK45099.1 - 0.00027 21.0 0.0 0.0032 17.5 0.0 2.4 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 PIK45099.1 - 0.00044 20.3 0.4 0.0066 16.5 0.0 2.8 2 1 2 4 4 4 1 SLIDE Myb_DNA-bind_6 PF13921.6 PIK45099.1 - 0.055 13.7 0.6 5.2 7.4 0.2 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain ASC PF00858.24 PIK45100.1 - 2.8e-35 122.2 0.7 3.4e-35 121.9 0.7 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.24 PIK45102.1 - 5.7e-83 279.3 12.3 6.7e-83 279.1 12.3 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel SUI1 PF01253.22 PIK45103.1 - 0.065 13.8 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor SUI1 OATP PF03137.20 PIK45105.1 - 1.1e-59 202.2 10.0 1.3e-59 202.0 10.0 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK45105.1 - 3.3e-08 33.5 8.6 9.5e-08 32.0 8.6 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Glucos_trans_II PF14264.6 PIK45105.1 - 0.0013 18.1 0.1 0.0013 18.1 0.1 1.9 2 0 0 2 2 2 1 Glucosyl transferase GtrII Kazal_1 PF00050.21 PIK45105.1 - 0.0048 16.9 10.4 0.012 15.6 10.4 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Peptidase_S66 PF02016.15 PIK45106.1 - 0.013 15.6 0.0 0.035 14.2 0.0 1.8 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain RT_RNaseH_2 PF17919.1 PIK45107.1 - 5.8e-05 23.1 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK45107.1 - 8e-05 22.4 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH PF17917.1 PIK45107.1 - 0.00032 20.9 0.0 0.0007 19.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 PIK45107.1 - 0.0055 16.9 0.0 0.0099 16.1 0.0 1.3 1 0 0 1 1 1 1 RNase H Dak1 PF02733.17 PIK45107.1 - 0.19 10.6 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Dak1 domain OATP PF03137.20 PIK45108.1 - 6.1e-88 295.5 16.3 1.7e-45 155.3 11.1 2.2 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK45108.1 - 6.7e-07 29.3 10.5 1.3e-06 28.4 10.5 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 PIK45108.1 - 2.8e-05 23.2 34.1 0.00011 21.2 4.3 3.9 5 0 0 5 5 5 3 Major Facilitator Superfamily Kazal_1 PF00050.21 PIK45108.1 - 0.0051 16.8 9.3 0.011 15.7 9.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF4386 PF14329.6 PIK45108.1 - 4.1 7.2 13.4 0.068 13.0 0.7 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4386) Proteasome PF00227.26 PIK45109.1 - 8e-53 178.8 0.2 1e-52 178.4 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 PIK45109.1 - 5.4e-14 51.5 0.2 9.4e-14 50.8 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature WD40 PF00400.32 PIK45110.1 - 1.3e-10 41.7 1.1 0.0034 18.2 0.0 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK45110.1 - 0.0083 16.4 0.0 8.2 6.8 0.0 3.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 PIK45110.1 - 0.025 14.6 0.0 0.45 10.6 0.0 2.7 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region IKI3 PF04762.12 PIK45110.1 - 0.028 12.4 0.0 0.31 9.0 0.0 2.0 1 1 1 2 2 2 0 IKI3 family Helicase_Sgs1 PF11408.8 PIK45110.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Sgs1 RecQ helicase Lyase_1 PF00206.20 PIK45111.1 - 1.2e-95 320.5 0.1 6.1e-69 232.8 0.1 2.2 1 1 1 2 2 2 2 Lyase FumaraseC_C PF10415.9 PIK45111.1 - 5.2e-22 78.0 0.2 1.2e-21 76.9 0.2 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus DUF4288 PF14119.6 PIK45111.1 - 0.0052 17.2 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4288) tRNA-synt_2b PF00587.25 PIK45113.1 - 4.5e-26 91.9 0.0 8.3e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 PIK45113.1 - 0.0011 19.2 0.5 0.0011 19.2 0.5 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain KLRAQ PF10205.9 PIK45114.1 - 6.8e-22 77.6 14.2 7.7e-22 77.4 14.2 1.0 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Csm1_N PF18504.1 PIK45114.1 - 0.002 18.4 4.6 0.002 18.4 4.6 2.2 1 1 1 2 2 2 1 Csm1 N-terminal domain Tropomyosin_1 PF12718.7 PIK45114.1 - 0.004 17.3 7.3 0.004 17.3 7.3 2.0 1 1 1 2 2 2 1 Tropomyosin like TMCO5 PF14992.6 PIK45114.1 - 0.02 14.5 14.0 0.021 14.4 14.0 1.0 1 0 0 1 1 1 0 TMCO5 family DivIC PF04977.15 PIK45114.1 - 0.024 14.4 18.8 0.24 11.2 5.6 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF4559 PF15112.6 PIK45114.1 - 0.034 13.8 6.5 0.04 13.6 6.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) ZapB PF06005.12 PIK45114.1 - 0.047 14.1 20.0 1 9.8 7.2 2.1 1 1 1 2 2 2 0 Cell division protein ZapB Glyco_hydro_106 PF17132.4 PIK45114.1 - 0.087 11.1 1.9 0.096 10.9 1.9 1.0 1 0 0 1 1 1 0 alpha-L-rhamnosidase Spc7 PF08317.11 PIK45114.1 - 0.13 11.1 14.8 0.15 11.0 14.8 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein bZIP_1 PF00170.21 PIK45114.1 - 0.28 11.3 13.5 0.18 11.9 3.3 2.3 1 1 1 2 2 2 0 bZIP transcription factor FapA PF03961.13 PIK45114.1 - 0.34 9.5 13.9 0.35 9.4 13.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 PIK45114.1 - 0.36 11.3 6.6 1.1 9.7 1.0 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) YabA PF06156.13 PIK45114.1 - 0.44 11.2 13.1 3.3 8.4 4.0 2.0 1 1 1 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 PIK45114.1 - 0.64 10.3 13.3 1.1 9.5 1.9 2.5 2 1 0 2 2 2 0 Homeobox associated leucine zipper CREPT PF16566.5 PIK45114.1 - 0.65 10.2 10.0 0.74 10.0 9.4 1.3 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TSNAXIP1_N PF15739.5 PIK45114.1 - 0.75 10.2 11.6 0.49 10.8 10.1 1.4 1 1 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DHR10 PF18595.1 PIK45114.1 - 0.83 9.7 18.4 1.4 9.0 7.3 2.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Prominin PF05478.11 PIK45114.1 - 0.89 7.4 9.5 0.98 7.3 9.5 1.0 1 0 0 1 1 1 0 Prominin PCRF PF03462.18 PIK45114.1 - 0.9 9.4 8.3 0.9 9.4 8.3 1.0 1 0 0 1 1 1 0 PCRF domain Atg14 PF10186.9 PIK45114.1 - 0.99 8.4 13.8 1.1 8.2 13.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIVA PF05103.13 PIK45114.1 - 1.3 9.1 14.5 2.7 8.1 14.4 1.5 1 1 0 1 1 1 0 DivIVA protein V_ATPase_I PF01496.19 PIK45114.1 - 1.6 6.5 8.9 1.7 6.4 8.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 PIK45114.1 - 1.8 9.0 13.4 2.8 8.4 6.6 2.0 1 1 0 1 1 1 0 Centromere protein H (CENP-H) MbeD_MobD PF04899.12 PIK45114.1 - 2 8.6 9.9 1.2e+02 2.9 9.9 2.3 1 1 0 1 1 1 0 MbeD/MobD like DUF4472 PF14739.6 PIK45114.1 - 2.6 8.8 17.3 1.2 10.0 6.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) TSC22 PF01166.18 PIK45114.1 - 3 8.2 11.6 3.7 7.9 1.6 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF724 PF05266.14 PIK45114.1 - 3.6 7.4 11.7 4.1 7.2 11.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) USP8_interact PF08941.10 PIK45114.1 - 5.5 6.8 8.6 5.3 6.8 1.0 2.0 1 1 1 2 2 2 0 USP8 interacting UPF0242 PF06785.11 PIK45114.1 - 6.7 6.8 16.5 31 4.6 16.5 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 PIK45114.1 - 7.4 5.8 14.5 0.57 9.4 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FAM76 PF16046.5 PIK45115.1 - 0.00041 19.8 9.5 0.00041 19.8 9.5 2.2 1 1 1 2 2 2 1 FAM76 protein TMF_DNA_bd PF12329.8 PIK45115.1 - 0.57 10.2 47.6 1 9.4 4.3 6.3 3 2 3 6 6 6 0 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 PIK45115.1 - 0.69 10.3 46.6 3.9 7.9 22.2 2.3 1 1 1 2 2 2 0 Fez1 CEP63 PF17045.5 PIK45115.1 - 1 9.2 50.0 0.73 9.7 16.8 3.8 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa DUF4430 PF14478.6 PIK45119.1 - 0.066 13.8 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) DCAF17 PF15802.5 PIK45120.1 - 7.6e-80 268.9 5.5 1.3e-79 268.2 5.5 1.3 1 1 0 1 1 1 1 DDB1- and CUL4-associated factor 17 MIB_HERC2 PF06701.13 PIK45122.1 - 3.6e-49 164.9 28.3 1.8e-25 88.9 4.5 4.1 4 1 0 5 5 5 2 Mib_herc2 Ank_2 PF12796.7 PIK45122.1 - 4.2e-37 126.6 2.6 1.8e-10 41.3 1.2 5.8 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK45122.1 - 7.2e-33 112.5 6.5 6.7e-08 32.9 0.0 8.1 5 1 3 8 8 8 6 Ankyrin repeats (many copies) SH3_15 PF18346.1 PIK45122.1 - 6e-32 109.8 6.0 2.9e-18 65.9 0.4 4.1 5 0 0 5 5 5 2 Mind bomb SH3 repeat domain Ank_5 PF13857.6 PIK45122.1 - 8.1e-32 108.9 5.6 3e-10 40.1 0.1 7.2 3 1 5 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK45122.1 - 1.6e-31 107.4 7.3 3.5e-07 30.4 0.2 8.4 9 1 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 PIK45122.1 - 2.4e-23 79.6 0.9 0.00075 19.8 0.0 8.8 9 0 0 9 9 9 4 Ankyrin repeat ZZ PF00569.17 PIK45122.1 - 5.6e-09 35.7 10.1 1.5e-08 34.3 10.1 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type NfeD PF01957.18 PIK45122.1 - 0.00025 21.4 1.4 0.29 11.5 0.1 3.3 1 1 2 3 3 3 2 NfeD-like C-terminal, partner-binding Asp_protease PF09668.10 PIK45123.1 - 2.3e-59 198.6 1.4 3.4e-59 198.1 1.4 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK45123.1 - 4.6e-26 91.2 0.0 1e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK45123.1 - 3.3e-10 40.5 0.0 8.3e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 PIK45123.1 - 2.9e-07 30.1 0.0 5.7e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family RVP_2 PF08284.11 PIK45123.1 - 5.8e-06 26.1 0.1 1.2e-05 25.0 0.1 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 PIK45123.1 - 1.2e-05 25.5 0.1 2.5e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 PIK45123.1 - 0.075 12.9 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like CHASE3 PF05227.13 PIK45123.1 - 0.15 12.0 4.0 0.27 11.1 4.0 1.4 1 0 0 1 1 1 0 CHASE3 domain Sas10 PF09368.10 PIK45124.1 - 4.2e-28 97.6 11.4 4.2e-28 97.6 11.4 3.5 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 PIK45124.1 - 2.3e-14 53.8 0.1 2.3e-14 53.8 0.1 3.7 4 1 0 4 4 4 1 Sas10/Utp3/C1D family Pex2_Pex12 PF04757.14 PIK45125.1 - 1.3e-34 119.8 10.1 1.7e-34 119.4 10.1 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Gal_mutarotas_2 PF13802.6 PIK45128.1 - 5.2e-05 23.5 1.5 0.0002 21.6 1.1 2.4 2 1 1 3 3 3 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 PIK45129.1 - 6.7e-21 75.0 1.4 8.1e-21 74.7 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 C2-set_2 PF08205.12 PIK45130.1 - 5.7e-07 29.5 1.3 0.046 13.8 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK45130.1 - 4.5e-05 23.7 0.9 1.6 9.1 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK45130.1 - 0.00011 22.7 3.1 0.83 10.3 0.0 4.2 2 1 2 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK45130.1 - 0.00044 20.4 0.1 0.0031 17.7 0.1 2.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK45130.1 - 0.006 16.7 3.1 7.4 6.8 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin domain DUP PF00674.18 PIK45130.1 - 0.081 13.1 0.2 0.48 10.6 0.0 2.3 3 0 0 3 3 3 0 DUP family Glyco_hydro_31 PF01055.26 PIK45131.1 - 4.3e-43 148.1 0.4 6.5e-43 147.5 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 PIK45131.1 - 0.00019 21.7 0.7 0.00052 20.3 0.6 1.9 1 1 0 1 1 1 1 Galactose mutarotase-like MFS_1 PF07690.16 PIK45133.1 - 6.9e-09 35.1 0.5 7.8e-09 34.9 0.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK45133.1 - 0.00021 20.3 1.0 0.00026 20.0 1.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1440 PF07274.12 PIK45133.1 - 0.012 16.0 0.3 0.023 15.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) KRE1 PF17056.5 PIK45133.1 - 0.54 10.0 2.1 1.3 8.8 2.1 1.7 1 1 0 1 1 1 0 Killer toxin-resistance protein 1 Prefoldin PF02996.17 PIK45134.1 - 4e-32 110.6 0.2 4e-32 110.6 0.2 1.4 2 0 0 2 2 2 1 Prefoldin subunit zf-C4H2 PF10146.9 PIK45134.1 - 0.12 12.6 1.4 0.18 12.1 1.4 1.3 1 1 0 1 1 1 0 Zinc finger-containing protein MFS_1 PF07690.16 PIK45135.1 - 9.9e-07 28.0 5.3 9.9e-07 28.0 5.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK45135.1 - 1e-05 24.6 3.1 1.9e-05 23.8 3.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter PH_16 PF17838.1 PIK45136.1 - 1.7e-37 128.0 0.4 3.5e-37 127.0 0.4 1.6 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 PIK45136.1 - 9.1e-27 94.5 1.0 2.5e-26 93.0 1.0 1.8 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 PIK45136.1 - 0.001 19.6 0.1 0.0042 17.6 0.1 2.1 1 0 0 1 1 1 1 PH domain 7tm_1 PF00001.21 PIK45137.1 - 2.2e-56 191.1 0.0 2.3e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK45137.1 - 1.1e-08 35.2 6.0 1.1e-08 35.2 6.0 2.0 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK45137.1 - 1.5e-08 34.4 13.0 1.5e-08 34.4 13.0 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK45137.1 - 2.8e-06 27.2 16.1 5.1e-06 26.3 16.1 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK45137.1 - 4.9e-05 22.8 15.6 8e-05 22.1 15.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 PIK45137.1 - 0.0013 18.2 15.0 0.0018 17.7 15.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Hydrolase_4 PF12146.8 PIK45138.1 - 4.5e-38 130.9 0.0 5.1e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 PIK45138.1 - 0.0063 16.3 0.0 0.0096 15.7 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 PIK45138.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 PIK45138.1 - 0.023 14.3 0.0 1.9 8.0 0.0 2.3 2 1 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK45138.1 - 0.039 13.4 0.0 0.55 9.7 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family PGAP1 PF07819.13 PIK45138.1 - 0.076 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 PIK45138.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative esterase DUF4260 PF14079.6 PIK45139.1 - 0.17 11.9 0.0 0.48 10.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4260) DUF2072 PF09845.9 PIK45140.1 - 3.1 8.1 7.8 0.79 10.0 2.6 2.0 2 0 0 2 2 2 0 Zn-ribbon containing protein Ras PF00071.22 PIK45141.1 - 1.5e-40 138.4 0.0 1.8e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK45141.1 - 1e-26 93.5 0.0 1.5e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK45141.1 - 4e-13 49.2 0.0 4.8e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK45141.1 - 0.00078 18.9 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK45141.1 - 0.0022 18.1 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NPCBM PF08305.11 PIK45141.1 - 0.016 15.4 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 NPCBM/NEW2 domain Bap31 PF05529.12 PIK45142.1 - 4.6e-42 143.1 6.4 8.4e-42 142.2 6.4 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 PIK45142.1 - 2e-11 43.7 13.2 2e-11 43.7 13.2 1.8 2 1 0 2 2 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain APG6_N PF17675.1 PIK45142.1 - 0.0031 18.1 15.4 0.0046 17.5 15.4 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region UPF0242 PF06785.11 PIK45142.1 - 0.0038 17.4 5.3 0.0063 16.6 5.3 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 PIK45142.1 - 0.0063 15.4 10.5 0.0082 15.1 10.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 PIK45142.1 - 0.049 13.7 13.3 0.045 13.8 12.2 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PIG-U PF06728.13 PIK45142.1 - 0.061 12.4 3.2 0.09 11.8 3.2 1.2 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U FapA PF03961.13 PIK45142.1 - 0.062 11.9 5.7 0.075 11.6 5.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Wtap PF17098.5 PIK45142.1 - 0.062 13.2 9.2 0.1 12.5 9.2 1.5 1 1 0 1 1 1 0 WTAP/Mum2p family DUF4201 PF13870.6 PIK45142.1 - 0.16 11.7 12.4 0.052 13.3 7.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Cluap1 PF10234.9 PIK45142.1 - 0.2 11.0 12.2 0.63 9.4 10.7 1.8 1 1 1 2 2 2 0 Clusterin-associated protein-1 Renin_r PF07850.14 PIK45142.1 - 0.38 11.4 0.2 0.38 11.4 0.2 3.3 2 1 1 3 3 3 0 Renin receptor-like protein Cep57_CLD_2 PF14197.6 PIK45142.1 - 0.58 10.3 8.1 5.6 7.1 0.1 2.9 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 MCPsignal PF00015.21 PIK45142.1 - 0.66 9.8 6.4 0.26 11.1 2.7 1.9 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMF_TATA_bd PF12325.8 PIK45142.1 - 1.4 9.2 13.5 2.5 8.3 7.4 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.11 PIK45142.1 - 1.5 9.2 11.8 1.9 8.8 0.6 3.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3450 PF11932.8 PIK45142.1 - 1.8 7.8 11.6 0.51 9.6 5.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) KxDL PF10241.9 PIK45142.1 - 1.8 8.9 7.5 0.78 10.1 1.6 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein COG2 PF06148.11 PIK45142.1 - 1.9 8.6 8.4 0.5 10.5 4.6 1.8 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 PIK45142.1 - 2.1 9.0 6.9 1.6 9.4 4.5 2.0 2 0 0 2 2 2 0 Initiation control protein YabA DUF4337 PF14235.6 PIK45142.1 - 3 7.9 10.7 22 5.1 9.8 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) ATP-synt_E PF05680.12 PIK45142.1 - 3.6 8.0 7.5 1.2 9.5 4.2 1.9 1 1 1 2 2 2 0 ATP synthase E chain Sec34 PF04136.15 PIK45142.1 - 4 7.3 10.5 1.4 8.8 6.3 2.0 2 0 0 2 2 2 0 Sec34-like family CENP-H PF05837.12 PIK45142.1 - 4 7.9 13.2 5.9 7.4 0.4 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) RNA_POL_M_15KD PF02150.16 PIK45143.1 - 0.037 13.9 0.3 0.081 12.8 0.3 1.6 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit XPG_I_2 PF12813.7 PIK45143.1 - 0.078 12.4 0.0 0.75 9.2 0.0 2.1 2 0 0 2 2 2 0 XPG domain containing T2SSF PF00482.23 PIK45144.1 - 0.016 15.2 0.2 0.039 13.9 0.2 1.7 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF507 PF04368.13 PIK45144.1 - 0.035 14.0 2.3 0.036 14.0 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF507) CCDC-167 PF15188.6 PIK45144.1 - 0.35 11.2 8.5 1.7 9.0 4.4 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Pkinase_Tyr PF07714.17 PIK45145.1 - 5.3e-22 78.3 0.0 6.7e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45145.1 - 8.7e-22 77.7 0.0 1.2e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 PIK45146.1 - 2.5e-10 40.8 0.0 4.5e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 PIK45146.1 - 1.7e-09 37.8 0.0 3.2e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 PIK45146.1 - 0.0031 17.9 0.1 0.13 12.7 0.1 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 PIK45146.1 - 0.02 15.2 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SCHIP-1 PF10148.9 PIK45146.1 - 0.023 14.3 0.1 0.036 13.7 0.1 1.3 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 PH_16 PF17838.1 PIK45146.1 - 0.066 13.1 0.0 0.86 9.5 0.0 2.2 2 0 0 2 2 2 0 PH domain PH_13 PF16652.5 PIK45146.1 - 0.086 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 PIK45146.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Oxysterol_BP PF01237.18 PIK45147.1 - 2.3e-37 128.7 11.0 2.6e-34 118.7 0.1 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein CD20 PF04103.15 PIK45148.1 - 5.9e-08 33.0 13.4 5.9e-08 33.0 13.4 1.8 1 1 1 2 2 2 1 CD20-like family DUF2427 PF10348.9 PIK45148.1 - 0.0044 16.8 2.6 0.0044 16.8 2.6 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2427) Ost5 PF05251.12 PIK45148.1 - 0.075 13.3 1.3 0.075 13.3 1.3 2.9 2 1 1 3 3 3 0 Oligosaccharyltransferase subunit 5 DUF2754 PF10953.8 PIK45148.1 - 0.39 11.0 2.9 0.4 10.9 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2754) EMP70 PF02990.16 PIK45148.1 - 0.4 9.3 9.1 0.5 9.0 9.1 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 MAM PF00629.23 PIK45149.1 - 0 1122.3 6.9 1.2e-41 142.3 0.1 12.3 11 1 1 12 12 12 12 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK45149.1 - 1.1e-28 99.1 106.4 1e-08 35.2 10.8 7.1 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A PKD PF00801.20 PIK45149.1 - 9.7 6.1 11.9 19 5.2 0.0 5.1 5 0 0 5 5 5 0 PKD domain MAM PF00629.23 PIK45150.1 - 5.5e-22 78.4 0.1 2.6e-19 69.7 0.1 2.1 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu MAM PF00629.23 PIK45151.1 - 0 1283.8 5.3 7.5e-43 146.2 0.1 13.0 12 1 1 13 13 13 13 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK45151.1 - 2.8e-19 69.0 45.6 1.2e-09 38.2 9.4 3.9 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Exonuc_VIII PF06630.11 PIK45151.1 - 0.28 11.0 4.7 0.93 9.3 0.1 3.0 4 0 0 4 4 4 0 Enterobacterial exodeoxyribonuclease VIII MAM PF00629.23 PIK45152.1 - 7e-10 39.1 0.0 1.5e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu PRKCSH-like PF12999.7 PIK45152.1 - 0.051 13.4 3.5 0.089 12.6 3.5 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 PIK45153.1 - 1.2e-10 41.4 12.3 2e-10 40.7 12.3 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK45153.1 - 1.5e-08 34.8 2.4 2.6e-07 30.7 0.0 2.3 3 0 0 3 3 3 2 MAM domain, meprin/A5/mu MAM PF00629.23 PIK45154.1 - 3.5e-20 72.6 0.0 3.4e-15 56.3 0.0 2.5 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK45154.1 - 0.0081 16.4 0.7 0.016 15.4 0.7 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK45155.1 - 4e-31 108.1 0.1 3.8e-30 104.9 0.1 2.2 2 1 0 2 2 2 1 MAM domain, meprin/A5/mu TFR_dimer PF04253.15 PIK45156.1 - 4.2e-18 65.6 0.0 6.5e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 PIK45156.1 - 1e-10 41.6 0.0 4.7e-10 39.5 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 PIK45156.1 - 0.0021 17.8 0.0 0.0032 17.2 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 TFR_dimer PF04253.15 PIK45157.1 - 3e-29 101.6 0.0 5.9e-29 100.6 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 PIK45157.1 - 8.6e-22 77.8 0.0 2e-21 76.6 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 PIK45157.1 - 2.8e-10 40.1 0.0 6e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 PIK45157.1 - 0.00014 21.6 0.0 0.00025 20.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Nicastrin PF05450.15 PIK45157.1 - 0.0031 17.0 0.0 0.0079 15.7 0.0 1.6 1 0 0 1 1 1 1 Nicastrin DUF2371 PF10177.9 PIK45157.1 - 0.19 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Hist_deacetyl PF00850.19 PIK45158.1 - 8.4e-168 557.5 0.0 3.3e-87 292.8 0.0 2.2 2 0 0 2 2 2 2 Histone deacetylase domain TatC PF00902.18 PIK45158.1 - 0.2 11.4 3.7 0.43 10.4 3.7 1.4 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) CENP-N PF05238.13 PIK45158.1 - 0.35 10.1 3.6 0.51 9.6 3.6 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like SVIP PF15811.5 PIK45159.1 - 4.5e-14 52.7 9.9 6.2e-14 52.2 9.9 1.2 1 0 0 1 1 1 1 Small VCP/p97-interacting protein MDM10 PF12519.8 PIK45159.1 - 0.023 13.6 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Biopterin_H PF00351.21 PIK45160.1 - 6.3e-141 469.2 0.1 7.7e-141 468.9 0.1 1.0 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ABC_tran PF00005.27 PIK45162.1 - 1.6e-20 74.0 0.0 4.7e-20 72.5 0.0 1.8 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 PIK45162.1 - 1.1e-09 38.3 0.1 2e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 PIK45162.1 - 0.00014 21.8 0.1 0.00031 20.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 PIK45162.1 - 0.0007 19.1 0.2 0.069 12.6 0.1 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 PIK45162.1 - 0.0099 16.4 3.0 0.17 12.4 3.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK45162.1 - 0.017 15.5 0.1 0.046 14.1 0.0 1.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_11 PF13086.6 PIK45162.1 - 0.031 14.1 0.5 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 PIK45162.1 - 0.031 14.2 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 PIK45162.1 - 0.047 14.1 0.0 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 PIK45162.1 - 0.068 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK45162.1 - 0.075 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 PIK45162.1 - 0.077 12.7 0.0 0.077 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 PIK45162.1 - 0.1 12.5 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 PIK45162.1 - 0.14 12.1 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 PIK45162.1 - 0.16 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TYW3 PF02676.14 PIK45163.1 - 6.8e-34 117.1 0.8 1e-33 116.5 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase TYW3 zf-H2C2_2 PF13465.6 PIK45164.1 - 2.2e-14 53.1 17.9 5.1e-07 29.8 1.0 3.8 4 0 0 4 4 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK45164.1 - 1e-13 50.9 20.1 2.8e-05 24.3 0.9 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK45164.1 - 9.4e-11 41.6 16.0 0.00085 20.0 3.9 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK45164.1 - 5.6e-08 32.9 5.2 0.011 16.0 0.0 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK45164.1 - 1.6e-07 31.5 8.2 0.067 13.5 0.1 3.6 1 1 2 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK45164.1 - 3.7e-06 27.1 14.6 0.0002 21.6 0.2 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type SET PF00856.28 PIK45164.1 - 5.3e-06 26.9 0.0 0.00013 22.4 0.0 2.4 1 1 0 1 1 1 1 SET domain zf-C2H2_6 PF13912.6 PIK45164.1 - 9e-06 25.6 10.9 0.13 12.3 0.5 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HE PF16278.5 PIK45164.1 - 4.1e-05 23.9 4.8 1.1 9.8 0.8 3.6 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 PIK45164.1 - 0.041 14.2 4.8 0.31 11.4 2.3 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 PIK45164.1 - 0.11 12.5 15.4 0.34 11.0 2.0 3.4 1 1 2 3 3 3 0 BED zinc finger Spt46 PF17734.1 PIK45164.1 - 0.13 12.0 3.6 0.51 10.1 0.3 2.3 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 HypA PF01155.19 PIK45164.1 - 0.22 11.6 1.6 0.62 10.1 1.6 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_C7 PF14522.6 PIK45164.1 - 0.31 11.1 7.2 2.5 8.1 6.2 2.3 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 PIK45164.1 - 0.41 11.1 5.7 0.74 10.3 3.3 2.1 1 1 1 2 2 2 0 Cytochrome c3 Zn_ribbon_SprT PF17283.2 PIK45164.1 - 0.71 9.8 12.1 3.2 7.8 6.0 2.5 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Elf1 PF05129.13 PIK45164.1 - 0.9 9.6 4.3 1.3 9.1 0.9 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-H2C2_5 PF13909.6 PIK45164.1 - 1.3 8.9 16.5 0.74 9.6 1.9 3.1 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 PIK45164.1 - 3.2 7.8 7.1 2.6 8.1 0.9 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-CHY PF05495.12 PIK45164.1 - 5.4 7.6 12.1 6.2 7.4 0.9 2.8 1 1 2 3 3 3 0 CHY zinc finger DUF2256 PF10013.9 PIK45164.1 - 6.9 6.9 7.3 13 5.9 0.1 3.1 4 0 0 4 4 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Aminotran_1_2 PF00155.21 PIK45165.1 - 4.3e-05 22.9 0.0 7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II SRCR PF00530.18 PIK45167.1 - 0 1177.5 101.4 2.6e-31 108.1 2.7 13.0 13 0 0 13 13 13 13 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK45167.1 - 3.3e-68 226.3 35.9 5.7e-06 26.8 0.1 12.6 12 0 0 12 12 12 12 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK45167.1 - 4.8e-34 117.2 14.3 0.036 14.6 0.2 12.6 12 0 0 12 12 12 11 Hepsin, SRCR domain DUF2997 PF11211.8 PIK45167.1 - 1.5e-06 27.9 9.9 4.5 7.1 0.0 8.1 8 0 0 8 8 8 3 Protein of unknown function (DUF2997) NB PF04159.13 PIK45167.1 - 0.0019 18.2 14.6 6 7.0 0.1 5.0 5 0 0 5 5 5 3 NB glycoprotein Bac_chlorC PF02043.17 PIK45167.1 - 0.74 9.9 28.8 40 4.3 0.0 10.0 12 0 0 12 12 12 0 Bacteriochlorophyll C binding protein PheRS_DBD2 PF18554.1 PIK45167.1 - 0.82 9.7 5.3 1.2e+02 2.8 0.1 4.5 4 0 0 4 4 4 0 PheRS DNA binding domain 2 SRCR PF00530.18 PIK45168.1 - 1.8e-31 108.6 3.3 1.8e-31 108.6 3.3 2.0 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 PIK45168.1 - 9.8e-13 48.1 6.8 9.8e-13 48.1 6.8 3.2 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A SRCR_2 PF15494.6 PIK45168.1 - 0.00048 20.6 1.2 0.00085 19.8 0.1 2.0 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Sulfatase PF00884.23 PIK45169.1 - 7.6e-37 127.3 0.1 1.6e-34 119.7 0.0 2.0 1 1 1 2 2 2 2 Sulfatase Phosphodiest PF01663.22 PIK45169.1 - 0.029 14.0 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase CAP PF00188.26 PIK45170.1 - 5.3e-10 40.2 2.1 7e-10 39.8 2.1 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Pro_isomerase PF00160.21 PIK45171.1 - 3.8e-46 157.3 0.0 3.8e-46 157.3 0.0 2.5 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HLH PF00010.26 PIK45172.1 - 7.9e-17 61.0 1.1 1.8e-16 59.8 1.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RRM_5 PF13893.6 PIK45173.1 - 1.9e-45 153.5 5.0 7.6e-33 112.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK45173.1 - 6.8e-20 70.7 0.0 3.6e-09 36.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 PIK45173.1 - 1.4e-10 41.2 0.2 4.2e-10 39.7 0.0 1.8 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 PIK45173.1 - 6.2e-09 35.6 1.3 0.22 11.4 0.0 4.0 4 0 0 4 4 4 3 Occluded RNA-recognition motif 2OG-FeII_Oxy_3 PF13640.6 PIK45174.1 - 7.2e-15 55.7 0.2 1.8e-14 54.4 0.2 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.6 PIK45174.1 - 8.2e-05 23.0 1.6 0.0003 21.2 1.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK45174.1 - 0.0011 18.8 3.0 0.26 11.3 0.0 3.4 4 0 0 4 4 4 2 EF-hand domain SPARC_Ca_bdg PF10591.9 PIK45174.1 - 0.0018 18.6 0.3 0.0072 16.6 0.1 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.32 PIK45174.1 - 0.041 13.4 0.3 0.51 10.0 0.0 2.8 3 0 0 3 3 3 0 EF hand HTH_48 PF17906.1 PIK45174.1 - 0.072 13.2 0.1 11 6.2 0.0 3.1 3 0 0 3 3 3 0 HTH domain in Mos1 transposase Rib_5-P_isom_A PF06026.14 PIK45174.1 - 0.16 11.6 0.1 8.3 6.0 0.0 2.5 2 0 0 2 2 2 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) EF-hand_7 PF13499.6 PIK45175.1 - 2e-06 28.2 0.8 4.8e-06 26.9 0.8 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK45175.1 - 9.5e-06 24.8 0.0 0.0062 16.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK45175.1 - 1.8e-05 24.3 0.5 0.004 17.0 0.3 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 PIK45175.1 - 0.018 14.5 0.3 0.047 13.2 0.3 1.7 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 PIK45175.1 - 0.021 14.7 0.7 0.34 10.8 0.2 2.5 3 0 0 3 3 3 0 EF-hand domain pair 2OG-FeII_Oxy_3 PF13640.6 PIK45176.1 - 2.3e-12 47.6 2.6 1.1e-11 45.5 2.6 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HEAT_2 PF13646.6 PIK45177.1 - 7.7e-25 87.1 0.9 1.3e-12 47.9 0.1 2.6 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 PIK45177.1 - 4.3e-20 70.3 0.3 0.0009 19.7 0.0 5.5 5 0 0 5 5 5 5 PBS lyase HEAT-like repeat HEAT PF02985.22 PIK45177.1 - 4.2e-08 32.8 0.3 0.064 13.5 0.0 4.7 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 PIK45177.1 - 0.00021 21.2 0.1 1.9 8.6 0.0 3.9 2 2 2 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK45177.1 - 0.00092 19.7 0.0 2.3 8.8 0.0 3.4 3 1 0 3 3 3 2 HEAT-like repeat DUF438 PF04282.13 PIK45177.1 - 0.06 13.3 0.7 21 5.1 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF438) C9orf72-like PF15019.6 PIK45178.1 - 9.3e-13 48.3 0.5 1.3e-12 47.8 0.5 1.2 1 0 0 1 1 1 1 C9orf72-like protein family DUF4635 PF15466.6 PIK45178.1 - 0.044 13.3 0.2 0.044 13.3 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) 7tm_1 PF00001.21 PIK45179.1 - 1e-52 179.1 11.6 1.3e-52 178.8 11.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK45179.1 - 6.5e-06 25.7 9.3 6.5e-06 25.7 9.3 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK45179.1 - 0.0013 18.4 16.4 0.0013 18.4 16.4 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK45179.1 - 0.006 16.3 9.0 0.006 16.3 9.0 1.8 2 0 0 2 2 2 1 Olfactory receptor RVT_1 PF00078.27 PIK45180.1 - 1.1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 PIK45181.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like Sulfatase PF00884.23 PIK45183.1 - 1.7e-37 129.5 0.0 2e-37 129.3 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK45183.1 - 0.018 14.7 0.1 0.025 14.2 0.1 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 PIK45184.1 - 1.2e-29 103.6 3.3 1.5e-29 103.3 3.3 1.1 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK45184.1 - 2.2e-08 33.9 0.1 8.4e-08 32.0 0.0 1.8 2 0 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 PIK45184.1 - 0.00031 21.0 2.6 0.026 14.8 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4976) 7tm_2 PF00002.24 PIK45185.1 - 1.6e-32 112.8 15.1 2.1e-32 112.4 15.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK45185.1 - 6.2e-17 61.9 2.5 1.1e-16 61.1 2.5 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK45185.1 - 0.075 12.4 0.3 0.17 11.3 0.1 1.8 2 0 0 2 2 2 0 GPCR-Autoproteolysis INducing (GAIN) domain CrgA PF06781.12 PIK45185.1 - 0.081 13.0 6.6 0.27 11.3 0.2 2.9 3 0 0 3 3 3 0 Cell division protein CrgA 7tm_1 PF00001.21 PIK45185.1 - 0.76 9.1 9.6 1.6 8.0 9.6 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2663 PF10864.8 PIK45185.1 - 5.7 7.3 7.3 1.5 9.2 0.2 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF2663) Peptidase_M36 PF02128.15 PIK45187.1 - 5.1e-06 25.9 4.9 2.1 7.4 0.0 4.3 1 1 4 5 5 5 4 Fungalysin metallopeptidase (M36) AAA_assoc_2 PF16193.5 PIK45187.1 - 0.00043 20.6 3.8 11 6.4 0.1 4.4 1 1 1 4 4 4 1 AAA C-terminal domain Neuropep_like PF15161.6 PIK45187.1 - 0.0016 18.0 0.0 66 3.3 0.0 4.7 4 2 0 4 4 4 0 Neuropeptide-like DUF4325 PF14213.6 PIK45187.1 - 0.0062 16.2 0.2 31 4.4 0.0 3.8 4 0 0 4 4 4 0 STAS-like domain of unknown function (DUF4325) BolA PF01722.18 PIK45187.1 - 0.025 14.8 2.1 38 4.7 0.0 4.7 3 1 0 3 3 3 0 BolA-like protein RnaseA PF00074.20 PIK45187.1 - 0.028 14.9 1.0 19 5.7 0.0 3.9 3 1 1 4 4 4 0 Pancreatic ribonuclease PSD3 PF07626.11 PIK45187.1 - 0.031 14.8 6.9 24 5.5 0.2 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1587) STAT_bind PF02864.15 PIK45187.1 - 0.036 14.6 0.1 2.8 8.5 0.0 2.4 2 0 0 2 2 2 0 STAT protein, DNA binding domain Ig_6 PF18452.1 PIK45187.1 - 0.085 12.4 1.4 63 3.2 0.0 3.5 4 0 0 4 4 4 0 Immunoglobulin domain Tobravirus_2B PF05271.11 PIK45187.1 - 0.12 12.3 5.9 77 3.2 0.0 4.5 4 1 0 5 5 5 0 Tobravirus 2B protein DUF3519 PF12033.8 PIK45187.1 - 0.14 12.5 6.2 35 4.8 0.2 3.6 1 1 2 4 4 4 0 Protein of unknown function (DUF3519) bMG10 PF17973.1 PIK45187.1 - 0.14 12.3 2.7 20 5.4 0.0 3.9 2 2 0 4 4 4 0 Bacterial Alpha-2-macroglobulin MG10 domain VGCC_alpha2 PF08473.11 PIK45189.1 - 1.6e-13 50.2 0.0 2e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd dCache_1 PF02743.18 PIK45189.1 - 0.013 15.3 0.1 0.021 14.6 0.1 1.3 1 1 0 1 1 1 0 Cache domain VWA_N PF08399.11 PIK45190.1 - 1.5e-25 90.1 0.9 4.7e-25 88.4 0.9 1.9 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.28 PIK45190.1 - 5.9e-10 39.7 2.9 6.3e-10 39.6 1.8 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK45190.1 - 6.5e-09 36.4 0.4 1.4e-08 35.3 0.4 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 PIK45190.1 - 0.00038 20.3 5.6 0.02 14.7 0.0 2.5 2 1 0 2 2 2 2 Cache domain TMEM187 PF15100.6 PIK45191.1 - 3.5e-80 269.1 16.7 3.9e-80 268.9 16.7 1.0 1 0 0 1 1 1 1 TMEM187 protein family Sulfate_transp PF00916.20 PIK45192.1 - 4e-44 150.9 10.7 9.8e-43 146.3 1.6 2.8 1 1 1 2 2 2 2 Sulfate permease family CbtA PF09490.10 PIK45192.1 - 0.11 12.3 0.5 0.21 11.3 0.5 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Sulfate_transp PF00916.20 PIK45193.1 - 6.4e-100 334.5 15.9 8.1e-100 334.2 15.9 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 PIK45193.1 - 1.2e-17 63.6 0.0 2.3e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain DnaJ PF00226.31 PIK45194.1 - 5.8e-17 61.6 1.7 1.6e-16 60.2 0.5 2.5 2 0 0 2 2 2 1 DnaJ domain RAC_head PF16717.5 PIK45194.1 - 2.6e-16 60.4 15.0 2.6e-16 60.4 15.0 3.6 4 1 1 5 5 5 1 Ribosome-associated complex head domain Myb_DNA-binding PF00249.31 PIK45194.1 - 2.8e-16 59.5 6.5 5.4e-11 42.5 0.3 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK45194.1 - 5.1e-10 39.5 0.7 1.1e-05 25.5 0.3 3.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain cNMP_binding PF00027.29 PIK45195.1 - 4.5e-17 61.9 0.0 1.5e-05 25.0 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Rft-1 PF04506.13 PIK45196.1 - 8.3e-135 450.4 23.7 6.9e-134 447.4 23.7 1.9 1 1 0 1 1 1 1 Rft protein Deltameth_res PF16020.5 PIK45196.1 - 1.8 8.5 8.2 0.35 10.8 0.1 3.7 3 0 0 3 3 3 0 Deltamethrin resistance Btz PF09405.10 PIK45197.1 - 0.0053 17.0 3.3 0.008 16.4 3.3 1.2 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding YMF19 PF02326.15 PIK45197.1 - 0.015 16.0 0.0 0.037 14.8 0.0 1.7 1 0 0 1 1 1 0 Plant ATP synthase F0 FAM176 PF14851.6 PIK45197.1 - 0.029 14.0 0.1 0.043 13.5 0.1 1.4 1 0 0 1 1 1 0 FAM176 family VIR_N PF15912.5 PIK45198.1 - 0.083 12.5 0.7 0.096 12.3 0.7 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal CUB PF00431.20 PIK45199.1 - 2e-66 221.2 4.7 2.1e-32 111.7 0.0 3.2 3 0 0 3 3 3 2 CUB domain cEGF PF12662.7 PIK45199.1 - 1.9e-34 117.2 49.5 3.8e-11 42.7 1.7 7.3 6 0 0 6 6 6 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK45199.1 - 1.1e-33 115.2 88.2 6.6e-09 35.9 9.2 7.3 6 1 0 6 6 6 5 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK45199.1 - 2.1e-26 91.8 90.5 4.5e-08 33.2 9.3 7.1 6 1 0 6 6 6 5 Calcium-binding EGF domain EGF PF00008.27 PIK45199.1 - 8.6e-05 22.7 85.0 0.019 15.2 5.8 7.0 6 2 0 6 6 6 5 EGF-like domain EGF_3 PF12947.7 PIK45199.1 - 0.014 15.6 82.1 0.044 14.0 10.9 7.0 5 2 2 7 7 7 0 EGF domain ZoocinA_TRD PF16775.5 PIK45199.1 - 0.19 11.9 0.5 45 4.3 0.0 3.6 5 0 0 5 5 5 0 Target recognition domain of lytic exoenzyme Baculo_VP91_N PF08475.10 PIK45199.1 - 0.23 11.1 3.3 0.55 9.9 3.3 1.5 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal 7tm_1 PF00001.21 PIK45200.1 - 1.5e-42 145.7 14.5 1.9e-42 145.4 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK45200.1 - 7.3e-06 25.5 14.4 1.6e-05 24.5 14.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK45200.1 - 4.7e-05 23.2 10.1 4.7e-05 23.2 10.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Peroxin-13_N PF04088.13 PIK45200.1 - 0.0013 19.0 0.2 0.23 11.7 0.0 2.5 1 1 1 2 2 2 2 Peroxin 13, N-terminal region 7TM_GPCR_Srw PF10324.9 PIK45200.1 - 0.0021 17.4 16.9 0.056 12.7 10.5 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw PS-DH PF14765.6 PIK45200.1 - 0.14 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Polyketide synthase dehydratase ArfGap PF01412.18 PIK45202.1 - 2.9e-31 108.0 0.3 2.9e-31 108.0 0.3 2.6 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf DUF572 PF04502.13 PIK45203.1 - 3.4e-50 171.6 9.1 3.4e-50 171.6 9.1 2.8 2 1 1 3 3 3 1 Family of unknown function (DUF572) ZZ PF00569.17 PIK45203.1 - 2.5 8.0 5.6 11 6.0 0.5 3.0 3 0 0 3 3 3 0 Zinc finger, ZZ type DUF3429 PF11911.8 PIK45204.1 - 1.4e-37 129.1 11.2 1.9e-37 128.8 11.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF2909 PF11137.8 PIK45204.1 - 0.32 11.0 1.8 0.71 9.8 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Vasculin PF15337.6 PIK45206.1 - 2.7e-29 101.9 3.9 2.7e-29 101.9 3.9 2.8 2 1 1 3 3 3 1 Vascular protein family Vasculin-like 1 DOT1 PF08123.13 PIK45207.1 - 3e-71 239.2 0.0 6.7e-71 238.1 0.0 1.6 1 0 0 1 1 1 1 Histone methylation protein DOT1 DUF1192 PF06698.11 PIK45207.1 - 0.14 12.2 1.9 0.46 10.6 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DASH_Dad3 PF08656.10 PIK45207.1 - 6.3 7.0 13.3 0.27 11.3 1.2 3.8 3 1 1 4 4 4 0 DASH complex subunit Dad3 Choline_transpo PF04515.12 PIK45209.1 - 1.1e-93 314.1 40.0 1.1e-93 314.1 40.0 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter HCMV_UL139 PF12507.8 PIK45209.1 - 0.62 10.4 2.5 12 6.3 0.4 2.4 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein SNF PF00209.18 PIK45210.1 - 4e-30 105.0 3.6 4.3e-30 104.9 3.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 PIK45211.1 - 6.9e-130 434.2 19.1 8.3e-130 433.9 19.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family NfI_DNAbd_pre-N PF10524.9 PIK45213.1 - 4.2e-26 90.5 4.2 7.3e-26 89.8 4.2 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.16 PIK45213.1 - 2.9e-12 46.7 2.1 8.9e-12 45.1 2.1 1.8 1 1 0 1 1 1 1 MH1 domain DUF2270 PF10028.9 PIK45213.1 - 0.01 15.4 0.4 0.015 14.9 0.4 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) Dehyd-heme_bind PF09098.10 PIK45213.1 - 0.042 13.5 0.2 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Rotamase_2 PF13145.6 PIK45213.1 - 0.29 12.0 3.4 0.44 11.4 3.4 1.2 1 0 0 1 1 1 0 PPIC-type PPIASE domain Pet100 PF09803.9 PIK45213.1 - 0.47 11.0 3.1 0.69 10.5 2.4 1.6 2 0 0 2 2 2 0 Pet100 DHHC PF01529.20 PIK45214.1 - 5.8e-27 94.4 12.8 5.8e-27 94.4 12.8 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF1272 PF06906.11 PIK45214.1 - 0.63 10.2 6.4 2.8 8.1 6.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) IGFBP PF00219.18 PIK45214.1 - 3.1 8.5 10.9 0.6 10.8 6.8 1.9 2 0 0 2 2 2 0 Insulin-like growth factor binding protein WD40 PF00400.32 PIK45215.1 - 0.012 16.5 0.2 3.1 8.8 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF3276 PF11680.8 PIK45215.1 - 0.026 14.6 5.9 0.083 13.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) CCT PF06203.14 PIK45215.1 - 0.19 11.8 4.5 0.41 10.7 4.5 1.5 1 0 0 1 1 1 0 CCT motif Spore_III_AB PF09548.10 PIK45215.1 - 0.6 10.2 3.7 1.1 9.4 3.7 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) PIP5K PF01504.18 PIK45215.1 - 1.2 8.4 8.7 0.083 12.1 2.6 2.1 2 1 1 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2992 PF11208.8 PIK45215.1 - 4 7.7 16.3 0.11 12.8 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) DUF5128 PF17170.4 PIK45216.1 - 0.012 14.7 0.1 0.018 14.2 0.1 1.3 1 1 0 1 1 1 0 6-bladed beta-propeller DED PF01335.21 PIK45217.1 - 0.0036 17.6 0.1 0.011 16.0 0.1 1.9 1 0 0 1 1 1 1 Death effector domain Fic_N PF13784.6 PIK45217.1 - 0.0068 16.4 0.7 0.014 15.4 0.1 1.9 2 0 0 2 2 2 1 Fic/DOC family N-terminal DUF5304 PF17230.2 PIK45217.1 - 0.0087 16.3 0.3 0.014 15.7 0.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5304) Baculo_PEP_C PF04513.12 PIK45217.1 - 0.013 15.6 0.1 0.035 14.1 0.0 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FmiP_Thoc5 PF09766.9 PIK45217.1 - 0.014 14.7 1.2 0.02 14.2 1.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF29 PF01724.16 PIK45217.1 - 0.46 10.7 4.4 0.11 12.7 1.1 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF29 Apolipoprotein PF01442.18 PIK45217.1 - 0.82 9.5 10.0 0.29 11.0 6.6 2.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain EamA PF00892.20 PIK45218.1 - 1.2e-11 44.9 34.6 6.7e-08 32.8 12.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family Zip PF02535.22 PIK45219.1 - 8.9e-59 199.4 12.5 8.9e-59 199.4 12.5 3.2 3 1 0 3 3 3 1 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK45219.1 - 3.4e-16 59.6 9.1 6.8e-15 55.4 1.7 2.5 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain SDA1 PF05285.12 PIK45219.1 - 0.03 13.8 0.6 0.05 13.0 0.6 1.2 1 0 0 1 1 1 0 SDA1 DUF5332 PF17266.2 PIK45219.1 - 0.29 10.8 2.3 0.66 9.6 0.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5332) DUF3188 PF11384.8 PIK45219.1 - 0.95 9.2 3.5 16 5.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) V-set PF07686.17 PIK45220.1 - 3.6e-11 43.2 1.4 5.7e-05 23.3 0.3 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK45220.1 - 1.3e-05 25.3 0.2 0.024 14.8 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK45220.1 - 1.3e-05 25.7 2.0 0.047 14.3 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK45220.1 - 0.03 14.4 0.1 4.5 7.4 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain A2M_recep PF07677.14 PIK45221.1 - 1.6e-17 64.0 2.8 2.2e-17 63.6 0.8 2.1 2 1 1 3 3 3 1 A-macroglobulin receptor binding domain TED_complement PF07678.14 PIK45221.1 - 1.1e-16 60.7 0.1 2.2e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 A-macroglobulin TED domain SQHop_cyclase_C PF13243.6 PIK45221.1 - 0.089 11.9 0.0 5.2 6.1 0.0 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain A2M_BRD PF07703.14 PIK45223.1 - 2.7e-13 50.4 0.0 6.2e-13 49.3 0.0 1.6 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain TED_complement PF07678.14 PIK45224.1 - 3.5e-85 285.8 0.0 4.6e-85 285.4 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_recep PF07677.14 PIK45224.1 - 5.1e-17 62.4 1.0 1.4e-16 60.9 1.0 1.8 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG3 PF17791.1 PIK45225.1 - 9.2e-19 67.5 0.0 2.9e-17 62.7 0.0 2.9 3 0 0 3 3 3 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK45225.1 - 1.2e-08 34.9 0.0 2.4e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Macroglobulin domain MG4 MG2 PF01835.19 PIK45225.1 - 0.0021 18.5 0.0 4.7 7.7 0.0 3.0 3 0 0 3 3 3 2 MG2 domain LIM PF00412.22 PIK45227.1 - 1.9e-32 111.2 21.1 1.2e-16 60.7 6.4 2.4 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 PIK45227.1 - 6.4e-11 41.9 0.5 1.3e-10 41.0 0.5 1.5 1 0 0 1 1 1 1 Homeodomain Furin-like_2 PF15913.5 PIK45227.1 - 0.021 15.0 8.2 0.021 15.0 8.2 2.0 1 1 0 1 1 1 0 Furin-like repeat, cysteine-rich Vps39_2 PF10367.9 PIK45227.1 - 7.8 7.0 9.1 2.8 8.4 2.9 2.9 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 2 zf-CDGSH PF09360.10 PIK45228.1 - 1.6e-16 60.2 8.9 1.7e-09 37.7 0.5 2.6 2 1 0 2 2 2 2 Iron-binding zinc finger CDGSH type CS PF04969.16 PIK45229.1 - 5.7e-13 49.7 0.5 1e-12 48.9 0.5 1.4 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.11 PIK45229.1 - 3.4e-07 30.5 1.7 3.4e-07 30.5 1.7 2.0 2 0 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.15 PIK45229.1 - 0.00034 20.6 0.1 0.00093 19.3 0.1 1.7 1 0 0 1 1 1 1 SGS domain DUF872 PF05915.12 PIK45231.1 - 0.8 9.9 6.3 0.14 12.4 0.6 2.4 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) FAD_SOX PF18371.1 PIK45232.1 - 1.9e-27 95.7 0.0 3.6e-26 91.6 0.0 2.4 2 1 0 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 PIK45232.1 - 4.2e-24 84.9 0.0 5.2e-23 81.4 0.1 2.6 2 0 0 2 2 2 1 Erv1 / Alr family QSOX_Trx1 PF18108.1 PIK45232.1 - 6.4e-09 36.0 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 QSOX Trx-like domain zf-LYAR PF08790.11 PIK45232.1 - 0.12 12.3 2.3 0.96 9.4 0.2 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger DUF2358 PF10184.9 PIK45232.1 - 0.16 12.3 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) CENP-Q PF13094.6 PIK45233.1 - 0.049 13.8 4.4 0.069 13.4 4.4 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DCB PF16213.5 PIK45233.1 - 0.072 12.8 0.1 0.1 12.2 0.1 1.3 1 1 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF2408 PF10303.9 PIK45233.1 - 0.08 13.5 1.1 0.13 12.8 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Luteo_P1-P2 PF08467.10 PIK45233.1 - 0.093 12.0 0.4 0.11 11.7 0.4 1.0 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase DUF1690 PF07956.11 PIK45233.1 - 0.66 10.4 4.1 0.55 10.7 1.1 1.9 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Fam20C PF06702.12 PIK45234.1 - 4.2e-83 278.5 1.1 5.7e-83 278.0 0.1 1.7 2 0 0 2 2 2 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK45234.1 - 0.03 13.2 0.0 0.069 12.0 0.0 1.5 1 0 0 1 1 1 0 FAM198 protein Cpn10 PF00166.21 PIK45234.1 - 0.031 14.3 0.1 0.071 13.2 0.1 1.6 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit WD40 PF00400.32 PIK45235.1 - 8.4e-39 130.9 8.2 5.7e-09 36.5 0.0 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK45235.1 - 1.2e-09 38.3 0.1 0.0045 17.3 0.0 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK45235.1 - 0.00056 19.0 0.0 1.6 7.6 0.0 3.1 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK45235.1 - 0.068 12.5 0.0 4.4 6.5 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain P_C10 PF14974.6 PIK45236.1 - 1.4e-34 118.3 0.3 1.6e-34 118.1 0.3 1.0 1 0 0 1 1 1 1 Protein C10 Activator-TraM PF11657.8 PIK45236.1 - 0.011 15.6 0.6 0.023 14.5 0.1 1.7 2 0 0 2 2 2 0 Transcriptional activator TraM TFCD_C PF12612.8 PIK45236.1 - 0.066 13.0 0.0 0.073 12.9 0.0 1.2 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal AMP-binding PF00501.28 PIK45237.1 - 4.1e-69 233.2 0.0 5.2e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK45237.1 - 8.8e-05 23.4 0.0 0.00023 22.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sulfotransfer_2 PF03567.14 PIK45238.1 - 2.2e-07 31.1 1.9 3.5e-07 30.4 1.9 1.3 1 1 0 1 1 1 1 Sulfotransferase family EF1G PF00647.19 PIK45238.1 - 0.032 14.3 0.2 0.053 13.6 0.2 1.5 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain Arc_C PF18162.1 PIK45238.1 - 0.064 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Arc C-lobe GH3 PF03321.13 PIK45239.1 - 7.5e-126 421.1 3.4 8.5e-126 420.9 3.4 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter GH3 PF03321.13 PIK45240.1 - 2.7e-62 211.4 0.0 3.1e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Cerato-platanin PF07249.12 PIK45240.1 - 0.047 13.8 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Cerato-platanin Nre_N PF04894.12 PIK45240.1 - 0.16 11.8 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Archaeal Nre, N-terminal GH3 PF03321.13 PIK45241.1 - 8.9e-37 127.1 0.0 1.1e-36 126.8 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Amnionless PF14828.6 PIK45241.1 - 0.15 10.8 2.1 0.51 9.1 0.0 2.0 2 0 0 2 2 2 0 Amnionless DUF2070 PF09843.9 PIK45241.1 - 0.57 8.4 6.5 0.78 7.9 6.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) GH3 PF03321.13 PIK45242.1 - 1.8e-72 244.9 1.8 2e-72 244.8 1.8 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter CM_2 PF01817.21 PIK45243.1 - 0.04 14.3 0.1 0.5 10.7 0.0 2.5 1 1 1 2 2 2 0 Chorismate mutase type II HATPase_c_3 PF13589.6 PIK45244.1 - 8.4e-14 51.6 0.0 1.9e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SMC_hinge PF06470.13 PIK45244.1 - 1.1e-08 35.4 0.0 2.8e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain HATPase_c PF02518.26 PIK45244.1 - 0.00052 20.5 0.0 0.0025 18.3 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 PIK45244.1 - 0.14 12.1 0.0 0.96 9.4 0.0 2.2 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Cep57_MT_bd PF06657.13 PIK45244.1 - 4.5 7.8 7.2 2.2 8.8 3.2 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 APG6_N PF17675.1 PIK45244.1 - 7.7 7.1 10.2 6.2 7.4 0.4 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region Vps5 PF09325.10 PIK45244.1 - 8.8 5.8 8.4 0.19 11.2 1.2 1.8 2 0 0 2 2 2 0 Vps5 C terminal like SAM_1 PF00536.30 PIK45245.1 - 1.3e-05 25.5 0.1 2.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK45245.1 - 3e-05 24.0 0.1 5.9e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FKBP_C PF00254.28 PIK45246.1 - 3.7e-24 84.9 0.0 5e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF2046 PF09755.9 PIK45249.1 - 0.0013 18.0 2.1 0.0013 18.0 2.1 1.4 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) SKA1 PF07160.12 PIK45249.1 - 0.0043 16.9 7.2 0.0066 16.3 7.2 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 TACC_C PF05010.14 PIK45249.1 - 0.0045 16.8 2.9 0.0071 16.2 2.9 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TSC22 PF01166.18 PIK45249.1 - 0.036 14.4 1.5 8.4 6.8 0.1 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family SHE3 PF17078.5 PIK45249.1 - 0.052 13.3 4.5 0.089 12.5 4.5 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 CtIP_N PF10482.9 PIK45249.1 - 0.33 11.0 8.3 0.82 9.7 8.3 1.7 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain ALMT PF11744.8 PIK45249.1 - 4.5 6.0 5.9 6.3 5.5 5.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CENP-H PF05837.12 PIK45249.1 - 4.8 7.6 7.1 1.5 9.3 3.4 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) SAE2 PF08573.10 PIK45250.1 - 4.4e-08 34.2 11.6 5.8e-05 24.2 0.6 3.5 2 1 1 3 3 3 2 DNA repair protein endonuclease SAE2/CtIP C-terminus Serpin PF00079.20 PIK45251.1 - 1.7e-87 294.2 0.2 2.1e-87 293.9 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Speriolin_C PF15059.6 PIK45252.1 - 0.01 16.0 1.5 0.063 13.4 0.2 2.4 2 0 0 2 2 2 0 Speriolin C-terminus CARD PF00619.21 PIK45252.1 - 0.036 14.1 0.5 0.036 14.1 0.5 2.8 3 0 0 3 3 3 0 Caspase recruitment domain RNase_T PF00929.24 PIK45252.1 - 0.04 14.5 0.3 5.6 7.5 0.0 3.1 4 0 0 4 4 4 0 Exonuclease Asp_protease_2 PF13650.6 PIK45255.1 - 0.00084 19.9 0.0 0.0031 18.1 0.0 2.0 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK45255.1 - 0.0016 18.4 3.0 0.0043 17.1 3.0 1.8 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK45255.1 - 0.0017 18.9 0.0 0.0088 16.6 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.6 PIK45255.1 - 0.0028 17.3 2.1 0.0028 17.3 2.1 2.0 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger TFB6 PF17110.5 PIK45255.1 - 1.2 8.9 4.4 0.91 9.2 2.1 1.9 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4198 PF10670.9 PIK45256.1 - 0.2 12.0 0.0 0.26 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) RVT_1 PF00078.27 PIK45257.1 - 2.2e-05 24.1 0.0 0.00011 21.8 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK45257.1 - 0.00016 21.5 16.1 0.0065 16.5 3.3 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45257.1 - 0.00027 20.7 6.3 0.0058 16.4 0.2 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45257.1 - 0.002 17.8 14.2 0.99 9.2 1.1 3.4 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK45257.1 - 2.6 8.3 11.7 0.99 9.7 6.6 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 PIK45258.1 - 5.4e-39 134.0 0.0 6.8e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SH3_4 PF06347.13 PIK45258.1 - 0.13 12.1 0.4 0.25 11.2 0.4 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain BEN PF10523.9 PIK45259.1 - 4.6e-08 33.2 0.0 1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 BEN domain DUF4806 PF16064.5 PIK45259.1 - 0.026 14.8 0.0 0.055 13.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) RVT_1 PF00078.27 PIK45260.1 - 5.8e-25 88.1 0.0 9.2e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5641 PF18701.1 PIK45261.1 - 5e-27 93.9 4.2 1e-26 92.9 4.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) 4HB_MCP_1 PF12729.7 PIK45261.1 - 0.062 12.8 0.2 0.096 12.2 0.2 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction BDV_P24 PF06595.11 PIK45262.1 - 0.003 17.5 0.0 0.0038 17.2 0.0 1.1 1 0 0 1 1 1 1 Borna disease virus P24 protein SAM_1 PF00536.30 PIK45262.1 - 0.029 14.8 0.0 0.092 13.2 0.0 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) RVT_1 PF00078.27 PIK45263.1 - 5.1e-35 121.0 0.0 6.5e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK45265.1 - 6.7e-06 26.7 0.8 6.7e-06 26.7 0.8 2.0 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase PIF1 PF05970.14 PIK45268.1 - 4.1e-20 72.3 0.0 4.6e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 PIK45268.1 - 9.7e-17 61.3 0.0 1.4e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK45268.1 - 5.5e-11 43.0 0.0 7.1e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK45268.1 - 0.071 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain RVT_1 PF00078.27 PIK45270.1 - 7.6e-25 87.7 0.1 8.3e-25 87.6 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK45271.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK45273.1 - 3.4e-11 43.1 0.0 9e-10 38.4 0.0 2.8 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK45274.1 - 1.3e-15 57.2 0.5 2.4e-15 56.4 0.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK45274.1 - 1.4e-12 47.9 0.0 2.2e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK45274.1 - 8.6e-07 29.1 0.2 1.6e-06 28.2 0.2 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Ferrochelatase PF00762.19 PIK45274.1 - 0.012 14.7 0.0 0.6 9.1 0.0 2.1 2 0 0 2 2 2 0 Ferrochelatase Agenet PF05641.12 PIK45274.1 - 0.038 14.5 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 Agenet domain DUF4537 PF15057.6 PIK45274.1 - 0.045 13.8 0.0 0.075 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) NOPS PF08075.11 PIK45274.1 - 0.14 12.3 0.0 2.2 8.6 0.0 2.3 2 0 0 2 2 2 0 NOPS (NUC059) domain RVT_1 PF00078.27 PIK45275.1 - 9.7e-07 28.5 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 PIK45276.1 - 1.3e-118 387.7 5.7 1.3e-17 64.2 0.0 8.3 8 0 0 8 8 8 8 Immunoglobulin domain I-set PF07679.16 PIK45276.1 - 1e-108 355.6 0.0 1.4e-16 60.3 0.0 8.4 8 0 0 8 8 8 8 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK45276.1 - 4.8e-80 263.9 0.0 3e-10 40.3 0.0 8.3 8 0 0 8 8 8 8 Immunoglobulin domain ig PF00047.25 PIK45276.1 - 3.4e-73 241.9 0.0 3.1e-10 40.1 0.0 8.6 8 0 0 8 8 8 8 Immunoglobulin domain Laminin_G_1 PF00054.23 PIK45276.1 - 3.8e-39 133.9 0.0 6.2e-22 78.2 0.0 2.7 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 PIK45276.1 - 1e-38 132.8 0.0 1.3e-23 83.9 0.0 2.5 2 0 0 2 2 2 2 Laminin G domain V-set PF07686.17 PIK45276.1 - 3.9e-37 126.8 10.2 0.0091 16.2 0.0 14.3 9 6 5 14 14 14 10 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK45276.1 - 9.2e-22 76.9 1.9 0.0042 17.1 0.0 7.5 7 0 0 7 7 7 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK45276.1 - 7.7e-20 70.2 0.0 0.099 12.2 0.0 8.5 8 0 0 8 8 8 4 Immunoglobulin domain Ig_5 PF16681.5 PIK45276.1 - 1.5e-14 54.1 0.0 0.29 11.6 0.0 8.2 8 0 0 8 8 8 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK45276.1 - 3.9e-13 49.3 0.1 0.68 10.0 0.0 7.8 8 0 0 8 8 8 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK45276.1 - 7.4e-12 45.4 0.0 0.16 12.2 0.0 7.7 8 0 0 8 8 8 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 PIK45276.1 - 3e-07 30.1 1.4 0.89 9.4 0.1 6.3 6 1 0 6 6 6 2 Adenovirus E3 region protein CR1 C2-set PF05790.15 PIK45276.1 - 5.9e-07 29.6 0.0 1.7 8.9 0.0 6.5 7 0 0 7 7 6 1 Immunoglobulin C2-set domain EGF PF00008.27 PIK45276.1 - 1.1e-06 28.9 20.7 0.00068 19.9 8.7 2.9 2 0 0 2 2 2 2 EGF-like domain Ig_C17orf99 PF17736.1 PIK45276.1 - 2e-06 27.7 1.6 23 5.1 0.0 7.9 8 2 0 8 8 7 0 C17orf99 Ig domain Laminin_G_3 PF13385.6 PIK45276.1 - 0.00019 21.6 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Receptor_2B4 PF11465.8 PIK45276.1 - 0.00021 21.4 0.7 1.8 8.8 0.0 5.0 5 1 1 6 6 5 1 Natural killer cell receptor 2B4 hEGF PF12661.7 PIK45276.1 - 0.04 14.6 16.4 0.3 11.8 4.3 3.6 2 0 0 2 2 2 0 Human growth factor-like EGF Herpes_gE PF02480.16 PIK45276.1 - 0.084 11.6 0.0 7.1 5.3 0.0 3.7 4 1 0 5 5 5 0 Alphaherpesvirus glycoprotein E cEGF PF12662.7 PIK45276.1 - 1.2 9.1 11.2 8 6.5 1.1 3.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Ig_3 PF13927.6 PIK45277.1 - 1.2e-17 64.2 0.5 5e-11 43.0 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK45277.1 - 4.3e-16 58.8 0.0 5.8e-11 42.3 0.0 2.3 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK45277.1 - 6.7e-13 48.8 0.0 1.3e-10 41.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK45277.1 - 1.3e-12 47.7 0.1 5.4e-09 36.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK45277.1 - 0.0003 20.9 0.4 1.1 9.4 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK45277.1 - 0.0014 18.6 0.3 0.04 14.0 0.0 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 PIK45277.1 - 0.032 14.2 0.0 0.094 12.8 0.0 1.7 2 0 0 2 2 2 0 C17orf99 Ig domain Laminin_B PF00052.18 PIK45278.1 - 8.8e-89 294.4 2.2 1.1e-33 116.1 0.0 3.9 3 1 1 4 4 4 3 Laminin B (Domain IV) Laminin_EGF PF00053.24 PIK45278.1 - 6e-50 167.2 176.8 6.1e-08 32.7 18.1 12.0 11 1 1 12 12 12 11 Laminin EGF domain I-set PF07679.16 PIK45278.1 - 1.3e-14 54.0 0.2 1.7e-05 24.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK45278.1 - 2.2e-14 53.8 2.1 0.00037 21.0 0.0 4.0 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK45278.1 - 1e-11 44.8 0.4 0.00017 21.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK45278.1 - 4.7e-11 42.8 1.6 0.0024 18.1 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK45278.1 - 1.2e-08 35.2 0.2 0.24 11.8 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 PIK45278.1 - 0.00049 19.6 0.0 0.11 12.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain zf-H2C2_2 PF13465.6 PIK45280.1 - 3.8e-30 102.9 36.6 9.4e-09 35.3 1.0 7.3 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK45280.1 - 3.3e-25 87.1 41.4 3.2e-05 24.2 5.0 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK45280.1 - 8.6e-18 63.5 38.9 0.0068 17.2 3.0 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK45280.1 - 6.1e-06 26.4 25.9 0.087 13.1 1.8 6.1 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK45280.1 - 0.00015 22.0 23.7 0.00068 19.9 3.1 4.8 1 1 3 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 PIK45280.1 - 0.00048 20.4 35.3 0.05 14.0 0.5 6.7 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-met2 PF12907.7 PIK45280.1 - 0.02 15.0 11.9 0.65 10.2 0.0 4.7 5 0 0 5 5 5 0 Zinc-binding zf-C2HE PF16278.5 PIK45280.1 - 0.033 14.7 24.8 3.7 8.1 8.9 5.1 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 PIK45280.1 - 0.036 14.4 23.2 0.83 10.0 1.1 5.7 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 PIK45280.1 - 0.083 13.6 13.8 7.5 7.2 0.9 4.2 1 1 4 5 5 5 0 Zinc finger C2H2-type, 3 repeats Spt46 PF17734.1 PIK45280.1 - 0.088 12.6 9.7 1.3 8.8 0.4 2.9 1 1 1 3 3 3 0 Spermatogenesis-associated protein 46 C1_4 PF07975.12 PIK45280.1 - 0.11 12.8 16.3 8.7 6.7 0.8 4.4 2 1 1 4 4 4 0 TFIIH C1-like domain DUF1999 PF09390.10 PIK45280.1 - 0.15 11.7 0.0 0.37 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1999) FdhD-NarQ PF02634.15 PIK45280.1 - 0.32 10.6 0.8 1.2 8.8 0.2 1.9 1 1 1 2 2 2 0 FdhD/NarQ family zf-C2H2_9 PF16293.5 PIK45280.1 - 0.42 10.5 3.1 4.4 7.2 0.0 3.7 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) BolA PF01722.18 PIK45280.1 - 0.47 10.8 3.4 2.5 8.4 0.1 3.1 2 1 2 4 4 4 0 BolA-like protein zf-C2H2_6 PF13912.6 PIK45280.1 - 1.6 8.8 42.9 0.11 12.5 3.3 6.6 7 0 0 7 7 7 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 PIK45280.1 - 2.1 8.5 21.4 5.9 7.1 1.0 4.9 2 2 4 6 6 6 0 Zinc ribbon domain zf_C2HC_14 PF18574.1 PIK45280.1 - 2.4 8.1 6.6 0.41 10.5 0.2 2.9 3 0 0 3 3 3 0 C2HC Zing finger domain zf-LYAR PF08790.11 PIK45280.1 - 2.4 8.1 15.9 9 6.3 0.1 5.3 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger C1_1 PF00130.22 PIK45280.1 - 3.1 7.7 17.1 5.6 6.9 1.6 4.3 2 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FOXP-CC PF16159.5 PIK45280.1 - 3.3 8.4 11.6 8.3 7.1 3.1 3.5 1 1 2 3 3 3 0 FOXP coiled-coil domain ATG7_N PF16420.5 PIK45281.1 - 2.6e-53 181.6 0.0 1.9e-51 175.5 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 PIK45281.1 - 7.9e-44 149.8 0.0 1.2e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 PIK45281.1 - 0.035 14.2 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 PIK45281.1 - 0.039 13.3 0.0 1.2 8.4 0.0 2.7 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FERM_M PF00373.18 PIK45283.1 - 2.2e-15 57.1 0.1 3.7e-15 56.4 0.1 1.3 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 PIK45283.1 - 8e-14 51.3 0.2 1.7e-13 50.3 0.2 1.5 1 0 0 1 1 1 1 FERM N-terminal domain DUF3338 PF11819.8 PIK45284.1 - 6.4e-23 81.2 7.9 4.2e-18 65.6 0.1 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF3338) DUF5446 PF17522.2 PIK45284.1 - 0.14 12.4 0.0 0.14 12.4 0.0 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5446) Lactamase_B_2 PF12706.7 PIK45285.1 - 6.5e-34 117.2 0.0 9.5e-34 116.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK45285.1 - 3.8e-12 46.4 0.0 4.9e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 PIK45285.1 - 0.15 12.1 2.9 0.41 10.6 2.9 1.8 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Peptidase_M16 PF00675.20 PIK45286.1 - 2.9e-55 186.3 0.1 4.5e-55 185.7 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 PIK45286.1 - 1.5e-35 122.9 0.0 8e-35 120.5 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Isy1 PF06246.12 PIK45287.1 - 1.4e-84 283.7 3.6 1.8e-84 283.3 3.6 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DUF4637 PF15470.6 PIK45287.1 - 1.3 8.8 4.8 2 8.1 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Ras PF00071.22 PIK45289.1 - 3e-58 196.0 1.2 3.5e-58 195.8 1.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK45289.1 - 3.5e-36 124.1 1.2 5.2e-36 123.5 1.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK45289.1 - 3.3e-16 59.2 0.4 4.2e-16 58.9 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK45289.1 - 0.0001 21.7 0.4 0.00013 21.4 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK45289.1 - 0.0023 17.4 0.1 0.003 17.0 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK45289.1 - 0.0053 16.8 0.1 0.0074 16.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 PIK45289.1 - 0.014 15.2 0.5 0.043 13.5 0.5 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK45289.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 PIK45289.1 - 0.021 15.1 0.5 0.043 14.1 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 PIK45289.1 - 0.058 13.4 0.1 0.098 12.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 PIK45289.1 - 0.063 13.0 0.3 0.16 11.7 0.3 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 PIK45289.1 - 0.07 13.5 0.1 0.1 13.0 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 PIK45289.1 - 0.074 12.9 0.8 3.3 7.6 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 PIK45289.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain GTP_EFTU PF00009.27 PIK45289.1 - 0.16 11.5 1.0 0.64 9.5 1.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain G6PD_C PF02781.16 PIK45290.1 - 8.6e-108 359.9 0.0 1.2e-107 359.5 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 PIK45290.1 - 1.5e-47 162.5 0.0 2.7e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glyco_transf_64 PF09258.10 PIK45293.1 - 2.6e-85 285.6 0.2 3e-85 285.4 0.2 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain ANAPC4_WD40 PF12894.7 PIK45294.1 - 2.4e-13 50.2 5.0 6.2e-05 23.2 0.0 5.8 2 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK45294.1 - 7.2e-07 29.8 4.5 0.6 11.1 0.0 5.9 7 0 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 PIK45294.1 - 7e-05 22.8 0.8 0.015 15.2 0.3 2.9 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 PIK45294.1 - 0.13 12.2 0.1 7.7 6.6 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ribosomal_L7Ae PF01248.26 PIK45295.1 - 1.7e-25 88.6 0.0 2e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HAD_2 PF13419.6 PIK45295.1 - 0.15 12.1 0.3 0.18 11.9 0.3 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.6 PIK45297.1 - 4e-12 46.3 0.0 6e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK45297.1 - 7.5e-06 26.6 0.0 1.4e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK45297.1 - 0.00017 21.4 0.0 0.00039 20.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK45297.1 - 0.0078 16.9 0.0 0.028 15.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK45297.1 - 0.12 13.1 0.0 0.53 11.0 0.0 2.2 2 2 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK45298.1 - 1.4e-07 31.5 0.1 3.1e-07 30.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK45298.1 - 0.00091 19.9 0.1 0.0026 18.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK45298.1 - 0.099 13.3 0.1 9.5 7.0 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain GPR_Gpa2_C PF11970.8 PIK45299.1 - 0.026 14.6 0.1 22 5.2 0.0 3.3 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF1218 PF06749.12 PIK45299.1 - 1.4 9.5 7.8 0.77 10.3 0.3 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1218) MtN3_slv PF03083.16 PIK45300.1 - 2.5e-36 123.6 11.4 2.5e-25 88.3 1.7 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 PIK45300.1 - 0.014 15.5 3.7 0.14 12.2 0.1 3.0 2 1 1 3 3 3 0 Lipid A Biosynthesis N-terminal domain PQ-loop PF04193.14 PIK45300.1 - 0.2 11.5 0.1 0.2 11.5 0.1 3.1 4 0 0 4 4 4 0 PQ loop repeat TRAM1 PF08390.11 PIK45301.1 - 6e-20 70.7 1.2 1.3e-19 69.6 0.0 2.3 2 0 0 2 2 2 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 PIK45301.1 - 2.9e-09 37.0 18.5 5.3e-08 32.8 1.9 2.7 3 1 1 4 4 4 2 TLC domain zf-rbx1 PF12678.7 PIK45302.1 - 0.00074 19.8 0.8 0.0019 18.4 0.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-PHD-like PF15446.6 PIK45302.1 - 0.012 15.2 7.6 0.23 11.1 0.4 2.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain PHD PF00628.29 PIK45302.1 - 0.016 15.1 2.4 0.016 15.1 2.4 1.7 2 0 0 2 2 2 0 PHD-finger CCDC117 PF15810.5 PIK45302.1 - 0.026 14.8 0.1 0.056 13.8 0.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 Zf_RING PF16744.5 PIK45302.1 - 0.07 13.2 1.7 0.07 13.2 1.7 1.8 2 0 0 2 2 2 0 KIAA1045 RING finger Bromodomain PF00439.25 PIK45303.1 - 1.8e-16 59.9 0.2 2.6e-15 56.2 0.1 2.3 2 0 0 2 2 2 1 Bromodomain PWWP PF00855.17 PIK45303.1 - 6.4e-08 32.9 0.2 4.7e-07 30.1 0.2 2.4 2 1 0 2 2 2 1 PWWP domain Zn_Tnp_IS91 PF14319.6 PIK45303.1 - 0.066 13.3 4.5 2.5 8.2 1.1 2.3 2 0 0 2 2 2 0 Transposase zinc-binding domain Fucose_iso_N2 PF07882.12 PIK45303.1 - 0.087 12.4 0.8 0.65 9.5 0.0 2.0 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain LMBR1 PF04791.16 PIK45304.1 - 0.0012 17.9 3.1 0.0015 17.5 3.1 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein zf-MYND PF01753.18 PIK45304.1 - 0.003 17.6 18.5 0.0056 16.7 18.5 1.5 1 0 0 1 1 1 1 MYND finger SlyX PF04102.12 PIK45304.1 - 0.17 12.5 4.2 0.6 10.8 3.2 2.4 2 0 0 2 2 2 0 SlyX GPS2_interact PF15784.5 PIK45304.1 - 7.3 7.1 11.3 1.3 9.6 6.1 2.4 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain zf-H2C2_2 PF13465.6 PIK45305.1 - 1.2e-26 91.9 50.3 1.2e-06 28.6 0.2 7.2 8 0 0 8 8 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK45305.1 - 1.7e-25 88.0 44.1 4.2e-07 30.1 2.0 6.5 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK45305.1 - 8.2e-18 63.6 37.7 0.00042 20.9 1.3 6.3 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK45305.1 - 1.1e-10 41.2 32.9 0.00042 20.2 1.9 5.5 5 0 0 5 5 5 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 PIK45305.1 - 2.5e-05 24.3 12.7 0.086 13.0 1.6 3.9 2 1 2 4 4 4 4 Zinc ribbon domain zf-C2H2_jaz PF12171.8 PIK45305.1 - 0.0004 20.6 27.9 0.039 14.2 0.1 5.8 6 0 0 6 6 5 2 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.14 PIK45305.1 - 0.0023 17.9 14.2 2.9 8.0 2.5 4.6 2 1 3 5 5 5 2 Adenylate kinase, active site lid zf_UBZ PF18439.1 PIK45305.1 - 0.015 14.9 11.1 1.8 8.2 0.1 4.9 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 PIK45305.1 - 0.056 13.5 14.1 4.2e+02 1.1 14.1 3.2 1 1 0 1 1 1 0 Double zinc ribbon zf-MYST PF17772.1 PIK45305.1 - 0.066 12.8 9.8 5.4 6.7 0.0 4.5 2 1 3 5 5 5 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 PIK45305.1 - 0.074 13.8 9.9 0.42 11.4 0.8 3.2 1 1 2 3 3 3 0 zinc-ribbon family DUF3268 PF11672.8 PIK45305.1 - 0.086 13.2 8.5 0.43 10.9 0.4 3.0 2 1 1 3 3 3 0 zinc-finger-containing domain zf-AN1 PF01428.16 PIK45305.1 - 0.34 11.1 15.9 13 6.1 0.3 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger zf-trcl PF13451.6 PIK45305.1 - 0.44 10.5 14.2 32 4.5 0.1 5.1 5 0 0 5 5 5 0 Probable zinc-ribbon domain HypA PF01155.19 PIK45305.1 - 0.52 10.3 8.7 7 6.7 2.9 2.8 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 PIK45305.1 - 0.52 10.4 13.3 9.7 6.3 0.6 4.5 2 1 3 5 5 5 0 CpXC protein zf-C2HC_2 PF13913.6 PIK45305.1 - 0.71 9.9 23.3 1.3 9.0 1.0 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Rpr2 PF04032.16 PIK45305.1 - 1.6 9.1 12.5 8.1 6.8 6.0 3.3 1 1 2 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-BED PF02892.15 PIK45305.1 - 2.1 8.4 27.8 1.8 8.7 0.2 5.0 1 1 4 5 5 5 0 BED zinc finger Zn_ribbon_SprT PF17283.2 PIK45305.1 - 2.2 8.3 16.4 1 9.3 2.0 3.9 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf-C2H2_3rep PF18868.1 PIK45305.1 - 2.2 9.0 18.7 8.4 7.1 0.6 5.3 2 1 4 6 6 5 0 Zinc finger C2H2-type, 3 repeats XPA_N PF01286.18 PIK45305.1 - 2.3 8.3 15.7 22 5.2 0.1 5.1 5 0 0 5 5 5 0 XPA protein N-terminal zf-met PF12874.7 PIK45305.1 - 2.5 8.6 20.9 0.74 10.3 0.2 5.0 6 0 0 6 6 5 0 Zinc-finger of C2H2 type Cript PF10235.9 PIK45305.1 - 3.3 8.3 15.5 2.1 8.9 2.0 4.1 1 1 3 4 4 3 0 Microtubule-associated protein CRIPT DUF2180 PF09947.9 PIK45305.1 - 6 6.9 9.8 9.9 6.2 1.6 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2HE PF16278.5 PIK45305.1 - 6.5 7.3 23.0 1.3 9.6 0.8 4.8 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf_ZIC PF18366.1 PIK45305.1 - 7.5 6.8 12.4 17 5.6 0.0 4.3 4 1 1 5 5 5 0 Zic proteins zinc finger domain RE_BstXI PF09552.10 PIK45306.1 - 0.053 12.7 0.0 0.073 12.3 0.0 1.2 1 0 0 1 1 1 0 BstXI restriction endonuclease SET PF00856.28 PIK45307.1 - 1.8e-06 28.4 0.0 2.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 SET domain zf-C2H2_6 PF13912.6 PIK45307.1 - 9.9e-05 22.2 15.4 0.061 13.3 1.4 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK45307.1 - 0.0001 22.5 25.3 0.025 15.0 0.5 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK45307.1 - 0.0019 18.6 19.5 0.0044 17.4 3.5 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK45307.1 - 0.0092 16.7 26.9 0.16 12.9 5.8 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger DUF2256 PF10013.9 PIK45307.1 - 0.015 15.4 6.7 7 6.8 0.2 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2HC_2 PF13913.6 PIK45307.1 - 0.025 14.5 3.0 0.025 14.5 3.0 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 PIK45307.1 - 0.073 12.7 6.4 0.11 12.2 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger PH_3 PF14593.6 PIK45307.1 - 0.081 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 PH domain Zn-ribbon_8 PF09723.10 PIK45307.1 - 1.1 9.4 8.4 11 6.2 3.1 2.9 1 1 1 2 2 2 0 Zinc ribbon domain zf-RING_UBOX PF13445.6 PIK45312.1 - 1.7e-09 37.6 5.0 1.7e-09 37.6 5.0 3.1 4 1 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK45312.1 - 2.9e-09 36.7 8.7 2.9e-09 36.7 8.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK45312.1 - 1.1e-07 31.9 9.6 1.1e-07 31.9 9.6 3.9 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK45312.1 - 2.5e-07 30.4 10.0 2.5e-07 30.4 10.0 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK45312.1 - 3.4e-07 30.5 8.8 3.4e-07 30.5 8.8 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK45312.1 - 0.00017 21.4 14.4 0.00017 21.4 14.4 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK45312.1 - 0.028 14.6 6.7 0.028 14.6 6.7 4.5 3 1 1 4 4 4 0 B-box zinc finger Zn-C2H2_12 PF18112.1 PIK45312.1 - 0.85 10.1 13.0 17 6.0 0.6 3.7 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain SelK_SelG PF10961.8 PIK45314.1 - 1.4e-23 83.3 0.4 1.7e-23 83.0 0.4 1.0 1 0 0 1 1 1 1 Selenoprotein SelK_SelG Actin PF00022.19 PIK45315.1 - 9.1e-37 126.6 0.0 5e-17 61.6 0.0 3.6 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 PIK45315.1 - 3.3e-10 39.7 0.0 0.0007 18.9 0.0 2.4 2 0 0 2 2 2 2 Putative actin-like family Laps PF10169.9 PIK45315.1 - 6.5e-10 39.7 8.4 1.6e-09 38.4 8.4 1.6 1 0 0 1 1 1 1 Learning-associated protein Proteasome PF00227.26 PIK45316.1 - 1.3e-44 152.0 0.0 1.8e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit PI3K_P85_iSH2 PF16454.5 PIK45316.1 - 0.024 14.2 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Proteasome PF00227.26 PIK45317.1 - 2.5e-48 164.1 0.7 2.5e-24 85.8 0.0 2.1 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 PIK45317.1 - 7.6e-14 51.1 0.0 1.5e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PI3K_P85_iSH2 PF16454.5 PIK45317.1 - 0.00073 19.2 0.0 0.00096 18.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain NAPRTase PF04095.16 PIK45318.1 - 9.6e-68 228.4 0.0 1.3e-67 228.0 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family zf-C2H2 PF00096.26 PIK45319.1 - 0.0014 19.0 2.7 0.0032 17.8 2.7 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK45319.1 - 0.099 13.5 1.5 0.29 12.1 1.5 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Aldedh PF00171.22 PIK45320.1 - 3.4e-179 596.2 0.0 3.2e-139 464.4 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Gal-3-0_sulfotr PF06990.11 PIK45321.1 - 4e-34 118.2 0.6 4.5e-34 118.0 0.6 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK45321.1 - 0.0065 16.0 0.2 0.01 15.3 0.2 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 PIK45321.1 - 0.0078 16.1 0.5 0.011 15.7 0.5 1.2 1 0 0 1 1 1 1 Sulfotransferase family TraD_N PF12615.8 PIK45321.1 - 0.097 13.4 0.0 0.19 12.5 0.0 1.6 1 1 0 1 1 1 0 F sex factor protein N terminal Ldl_recept_a PF00057.18 PIK45322.1 - 2.1e-20 72.6 40.8 1.2e-07 31.8 6.3 3.5 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK45322.1 - 1.9e-15 57.1 0.1 3.4e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 PIK45323.1 - 4e-21 74.9 61.0 1.3e-10 41.3 14.6 4.4 5 0 0 5 5 5 3 Low-density lipoprotein receptor domain class A DUF1128 PF06569.11 PIK45323.1 - 0.2 11.6 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Neur_chan_memb PF02932.16 PIK45324.1 - 4.3e-07 30.2 2.4 4.7e-05 23.6 0.0 2.1 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK45325.1 - 1.3e-23 83.6 0.3 1.8e-23 83.1 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK45325.1 - 2e-20 73.9 5.2 7.3e-19 68.8 1.8 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 PIK45326.1 - 1.5e-17 64.5 8.9 3.1e-15 56.9 4.2 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF4806 PF16064.5 PIK45328.1 - 3.1e-07 30.6 0.0 5.9e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4806) Matrilin_ccoil PF10393.9 PIK45328.1 - 0.041 13.7 0.6 0.076 12.9 0.6 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF659 PF04937.15 PIK45330.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF 659) DUF4371 PF14291.6 PIK45330.1 - 0.05 13.2 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 PIK45331.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region LMBR1 PF04791.16 PIK45332.1 - 0.73 8.7 4.5 0.87 8.4 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PIF1 PF05970.14 PIK45333.1 - 4.8e-08 32.6 0.0 6.7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.6 PIK45333.1 - 3.8e-07 30.5 0.0 6.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK45333.1 - 3.1e-05 23.8 0.0 4.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain zf-C2H2_10 PF16588.5 PIK45333.1 - 0.013 15.3 0.6 0.025 14.3 0.6 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK45333.1 - 0.1 12.6 6.6 0.15 12.1 1.0 2.9 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 PIK45333.1 - 0.18 12.0 11.0 0.18 11.9 0.5 2.9 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45333.1 - 0.32 10.8 4.8 6.5 6.6 0.4 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK45333.1 - 0.43 10.4 7.5 0.14 12.1 3.8 2.1 2 0 0 2 2 2 0 Zinc knuckle Exo_endo_phos_2 PF14529.6 PIK45336.1 - 3.1e-06 27.0 4.0 3.8e-06 26.7 1.9 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK45336.1 - 0.0008 19.0 0.0 0.0023 17.5 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UvrD_C_2 PF13538.6 PIK45336.1 - 0.086 12.7 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain MtrA PF04208.14 PIK45336.1 - 0.087 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A UPF0020 PF01170.18 PIK45336.1 - 0.15 11.7 0.5 11 5.7 0.0 2.8 2 1 1 3 3 3 0 Putative RNA methylase family UPF0020 AAA_30 PF13604.6 PIK45336.1 - 0.19 11.4 0.2 0.4 10.4 0.2 1.5 1 0 0 1 1 1 0 AAA domain RVT_1 PF00078.27 PIK45337.1 - 7.8e-14 51.7 0.0 4.8e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK45337.1 - 5.2e-08 32.7 0.3 9e-08 31.9 0.3 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK45337.1 - 0.056 13.3 0.0 0.14 12.0 0.0 1.7 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF4218 PF13960.6 PIK45338.1 - 0.00017 21.2 0.0 0.00031 20.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) RVT_1 PF00078.27 PIK45340.1 - 1.7e-06 27.7 0.0 6.1e-06 25.9 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4874 PF16173.5 PIK45341.1 - 0.066 12.9 0.2 0.11 12.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) PIF1 PF05970.14 PIK45342.1 - 0.0019 17.5 1.6 0.13 11.5 0.1 2.0 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 PIK45342.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain NCKAP5 PF15246.6 PIK45342.1 - 0.2 11.3 0.4 6 6.4 0.0 2.0 2 0 0 2 2 2 0 Nck-associated protein 5, Peripheral clock protein gag-asp_proteas PF13975.6 PIK45343.1 - 0.033 14.7 0.0 0.08 13.5 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK45343.1 - 0.057 14.1 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Presenilin PF01080.17 PIK45344.1 - 3.3 6.4 6.1 3.5 6.3 6.1 1.1 1 0 0 1 1 1 0 Presenilin LRR_8 PF13855.6 PIK45345.1 - 5.8e-30 102.9 46.6 6.3e-12 45.1 10.2 3.6 1 1 3 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK45345.1 - 5.4e-12 45.8 4.2 7.9e-08 32.3 1.4 1.8 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK45345.1 - 4.1e-11 42.9 34.6 1.5e-05 25.2 3.2 4.4 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK45345.1 - 0.00011 22.2 26.5 0.1 13.2 1.4 5.6 5 1 1 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK45345.1 - 0.00027 20.5 10.6 0.036 13.6 3.7 2.0 1 1 1 2 2 2 2 Leucine-rich repeat DDE_Tnp_IS1595 PF12762.7 PIK45347.1 - 5.3e-15 55.7 0.0 7.1e-15 55.3 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Vault PF01505.18 PIK45349.1 - 0.13 12.5 0.7 6.7 7.0 0.1 2.9 2 2 0 2 2 2 0 Major Vault Protein repeat domain OTU PF02338.19 PIK45350.1 - 1.6e-11 44.7 0.4 2.2e-11 44.3 0.4 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease FokI_C PF02980.16 PIK45350.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain Chromo PF00385.24 PIK45351.1 - 0.00015 21.6 0.2 0.00015 21.6 0.2 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 PIK45351.1 - 0.0087 16.2 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 MethyltransfD12 PF02086.15 PIK45351.1 - 0.043 13.5 0.1 0.049 13.3 0.1 1.0 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase U3_snoRNA_assoc PF08297.11 PIK45351.1 - 0.044 14.5 0.3 0.049 14.3 0.3 1.0 1 0 0 1 1 1 0 U3 snoRNA associated Tudor-knot PF11717.8 PIK45351.1 - 0.098 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Myc_N PF01056.18 PIK45351.1 - 0.11 12.4 1.3 0.12 12.3 1.3 1.0 1 0 0 1 1 1 0 Myc amino-terminal region MRVI1 PF05781.12 PIK45353.1 - 3.6e-33 115.1 5.7 3.6e-33 115.1 5.7 1.9 2 0 0 2 2 2 1 MRVI1 protein HAUS4 PF14735.6 PIK45353.1 - 5.4 6.7 14.0 0.7 9.6 2.7 2.6 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 4 TipAS PF07739.13 PIK45355.1 - 0.087 13.4 1.6 0.43 11.1 0.6 2.4 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain ALMT PF11744.8 PIK45355.1 - 1.6 7.5 6.2 2.3 7.0 6.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Atg14 PF10186.9 PIK45355.1 - 4.3 6.3 17.1 2.2 7.3 14.1 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Herpes_UL6 PF01763.16 PIK45355.1 - 6 5.2 11.1 1 7.8 6.2 1.8 1 1 1 2 2 2 0 Herpesvirus UL6 like Gal-3-0_sulfotr PF06990.11 PIK45356.1 - 7.7e-49 166.6 1.1 1e-48 166.2 1.1 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK45356.1 - 2.8e-06 27.4 1.2 2.1e-05 24.5 1.2 2.2 1 1 0 1 1 1 1 Sulfotransferase family DUF354 PF04007.12 PIK45356.1 - 0.0042 16.2 0.4 0.0081 15.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF354) Gelsolin PF00626.22 PIK45358.1 - 1e-53 179.1 1.0 1.1e-14 54.1 0.0 6.7 6 0 0 6 6 6 5 Gelsolin repeat LRR_8 PF13855.6 PIK45358.1 - 1.2e-37 127.5 40.8 2.9e-10 39.7 8.8 7.0 3 2 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 PIK45358.1 - 1.1e-23 82.9 50.9 4.5e-05 23.7 5.0 8.5 7 2 3 10 10 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK45358.1 - 3.3e-06 26.9 36.2 7.6 7.5 0.1 11.6 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK45358.1 - 0.0002 21.3 4.1 0.67 9.9 0.3 3.5 3 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) U1snRNP70_N PF12220.8 PIK45358.1 - 0.01 16.5 2.6 0.058 14.0 0.1 3.3 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LRR_6 PF13516.6 PIK45358.1 - 0.014 15.4 50.2 0.057 13.5 0.1 11.4 13 0 0 13 13 12 0 Leucine Rich repeat TSGP1 PF07771.11 PIK45358.1 - 0.033 14.3 0.5 0.091 12.9 0.5 1.7 1 0 0 1 1 1 0 Tick salivary peptide group 1 WD40_4 PF16300.5 PIK45358.1 - 0.062 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Type of WD40 repeat CopB PF05275.11 PIK45358.1 - 0.083 12.4 0.4 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 Copper resistance protein B precursor (CopB) LEDGF PF11467.8 PIK45358.1 - 0.14 11.8 0.4 0.52 9.9 0.4 2.0 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) REV PF00424.18 PIK45358.1 - 1.2 9.2 11.2 2.7 8.1 0.1 3.4 3 0 0 3 3 3 0 REV protein (anti-repression trans-activator protein) FXR_C1 PF16096.5 PIK45358.1 - 3 8.1 5.8 8.7 6.6 1.1 2.5 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 SPT6_acidic PF14632.6 PIK45358.1 - 3.1 8.5 9.8 0.46 11.1 3.8 2.7 2 0 0 2 2 2 0 Acidic N-terminal SPT6 TMEM52 PF14979.6 PIK45359.1 - 0.00023 21.1 4.3 0.18 11.7 0.7 2.4 1 1 1 2 2 2 2 Transmembrane 52 WBP-1 PF11669.8 PIK45359.1 - 0.028 15.1 0.1 5 7.8 0.0 2.4 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF2207 PF09972.9 PIK45359.1 - 0.096 11.4 0.1 0.12 11.2 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2633 PF11119.8 PIK45359.1 - 1.9 8.4 3.7 3.2 7.7 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2633) p450 PF00067.22 PIK45360.1 - 2e-63 214.8 0.1 3.6e-62 210.6 0.1 1.9 1 1 0 1 1 1 1 Cytochrome P450 UDPG_MGDP_dh PF00984.19 PIK45360.1 - 0.15 12.3 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain p450 PF00067.22 PIK45361.1 - 2.4e-15 56.2 0.0 2.9e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK45362.1 - 4.9e-83 279.4 0.0 1.5e-64 218.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 AAA PF00004.29 PIK45363.1 - 1.1e-07 32.3 0.1 6.7e-06 26.6 0.1 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK45363.1 - 0.00021 21.3 0.0 0.69 10.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 PIK45363.1 - 0.0018 18.3 0.1 0.061 13.2 0.0 3.0 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 PIK45363.1 - 0.0079 16.6 0.1 0.028 14.8 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 PIK45363.1 - 0.012 15.5 1.6 0.2 11.6 0.1 2.6 3 0 0 3 3 3 0 NTPase AAA_22 PF13401.6 PIK45363.1 - 0.018 15.3 0.0 0.26 11.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain AT_hook PF02178.19 PIK45363.1 - 0.036 13.9 16.9 0.39 10.8 4.1 4.4 3 0 0 3 3 3 0 AT hook motif AAA_lid_9 PF17871.1 PIK45364.1 - 0.028 14.3 0.8 0.11 12.4 0.2 1.9 2 0 0 2 2 2 0 AAA lid domain Peptidase_C26 PF07722.13 PIK45365.1 - 5.5e-20 72.0 0.0 9.5e-19 68.0 0.0 2.2 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 PIK45365.1 - 5.5e-14 52.4 0.0 9.3e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GalKase_gal_bdg PF10509.9 PIK45366.1 - 3.9e-22 77.6 0.0 6.9e-22 76.8 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 PIK45366.1 - 7.4e-11 42.3 0.0 1.3e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 PIK45366.1 - 8.5e-08 32.3 0.0 1.8e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain RVT_1 PF00078.27 PIK45367.1 - 1.2e-19 70.8 0.1 1.5e-19 70.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK45368.1 - 6.9e-20 71.5 0.1 1.4e-19 70.5 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK45368.1 - 0.00062 20.4 1.9 0.0025 18.5 1.9 2.1 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase TK PF00265.18 PIK45369.1 - 1.9e-64 216.8 0.3 2.4e-64 216.5 0.3 1.1 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.6 PIK45369.1 - 0.00028 20.9 0.0 0.00044 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 PIK45369.1 - 0.0043 17.0 0.0 0.0055 16.7 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF892 PF05974.12 PIK45369.1 - 0.13 12.3 1.2 0.27 11.3 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF892) RVT_1 PF00078.27 PIK45370.1 - 4.1e-20 72.2 0.0 6.2e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ig PF00047.25 PIK45371.1 - 4.1e-12 46.1 0.2 1.7e-08 34.5 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK45371.1 - 2.3e-09 37.7 0.3 2.6e-05 24.7 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK45371.1 - 3.6e-08 33.6 0.2 1.2e-06 28.6 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK45371.1 - 1.9e-07 31.3 0.9 0.02 15.2 0.2 3.5 2 2 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK45371.1 - 4.3e-07 29.9 0.1 5.1e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_6 PF18452.1 PIK45371.1 - 0.00034 20.1 1.0 0.00058 19.4 0.2 1.8 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK45371.1 - 0.0013 18.8 0.1 0.0022 18.0 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK45371.1 - 0.039 14.0 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain 7tm_1 PF00001.21 PIK45372.1 - 7.1e-55 186.2 2.0 9e-55 185.8 2.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK45372.1 - 3.7e-05 23.5 4.5 3.7e-05 23.5 4.5 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK45372.1 - 0.00094 18.6 13.1 0.0029 17.0 5.0 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0220 PF05255.11 PIK45372.1 - 0.041 13.4 6.7 0.034 13.7 1.5 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0220) DUF996 PF06195.13 PIK45372.1 - 1.2 9.4 7.7 0.26 11.6 3.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) MMR_HSR1 PF01926.23 PIK45373.1 - 1.6e-17 63.7 0.0 2.3e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK45373.1 - 1.2e-06 28.1 0.0 1.7e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK45373.1 - 1.3e-05 25.2 0.0 2.8e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 PIK45373.1 - 0.0011 18.6 0.0 0.21 11.1 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK45373.1 - 0.0031 17.0 0.0 0.0057 16.1 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 PIK45373.1 - 0.034 13.9 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 PIK45373.1 - 0.045 13.8 0.0 1.8 8.6 0.2 2.1 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 PIK45373.1 - 0.046 13.9 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 PIK45373.1 - 0.17 12.3 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 PIK45373.1 - 0.19 11.1 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Meckelin PF09773.9 PIK45374.1 - 0.41 8.7 4.4 0.45 8.5 4.4 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) DUF3242 PF11586.8 PIK45375.1 - 0.091 12.5 0.1 0.54 10.0 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3242) Cnd1 PF12717.7 PIK45376.1 - 0.0052 16.8 3.7 0.94 9.5 0.2 3.1 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK45376.1 - 0.0064 16.9 0.3 0.054 13.9 0.2 2.4 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 PIK45376.1 - 0.02 15.1 0.2 34 5.1 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat RPAP3_C PF13877.6 PIK45376.1 - 0.41 11.2 5.1 63 4.2 0.0 4.0 4 0 0 4 4 4 0 Potential Monad-binding region of RPAP3 Macro PF01661.21 PIK45377.1 - 0.19 11.8 5.3 0.48 10.5 0.1 3.1 3 0 0 3 3 3 0 Macro domain UQ_con PF00179.26 PIK45379.1 - 2.4e-43 147.2 0.1 3.1e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK45379.1 - 1.7e-07 31.0 0.0 3.3e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B UBA PF00627.31 PIK45379.1 - 1.1e-05 25.2 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain RWD PF05773.22 PIK45379.1 - 0.011 16.1 0.1 0.022 15.0 0.0 1.7 1 1 1 2 2 2 0 RWD domain UBA_4 PF14555.6 PIK45379.1 - 0.048 13.5 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain UEV PF05743.13 PIK45379.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 UEV domain Myelin_PLP PF01275.19 PIK45380.1 - 0.0032 17.4 0.1 0.0033 17.3 0.1 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) ARA70 PF12489.8 PIK45380.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Nuclear coactivator NADHdh_A3 PF14987.6 PIK45381.1 - 2.4e-07 31.0 0.1 3.1e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 alpha subcomplex subunit 3 OST-HTH PF12872.7 PIK45382.1 - 1.7e-07 30.9 0.1 0.0027 17.5 0.0 2.8 3 0 0 3 3 3 2 OST-HTH/LOTUS domain Limkain-b1 PF11608.8 PIK45383.1 - 3.6e-26 91.0 0.6 1.5e-24 85.9 0.1 3.0 3 0 0 3 3 3 1 Limkain b1 NYN PF01936.18 PIK45383.1 - 5.5e-19 69.1 0.1 1.2e-18 68.0 0.1 1.5 1 0 0 1 1 1 1 NYN domain OST-HTH PF12872.7 PIK45383.1 - 1.3e-15 57.0 0.0 5.3e-06 26.2 0.1 4.4 4 0 0 4 4 4 2 OST-HTH/LOTUS domain RRM_1 PF00076.22 PIK45383.1 - 5.4e-08 32.5 0.0 0.015 15.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGA2 PF07543.12 PIK45384.1 - 0.41 10.6 4.5 0.5 10.3 2.0 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 Alpha-2-MRAP_C PF06401.11 PIK45385.1 - 0.35 10.8 2.7 0.22 11.5 0.5 1.7 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain HYR PF02494.16 PIK45386.1 - 5.3e-37 126.0 85.8 1.5e-06 28.4 3.8 9.7 8 2 2 10 10 10 8 HYR domain TACI-CRD2 PF09305.10 PIK45386.1 - 0.021 14.8 13.9 59 3.8 0.1 7.2 7 0 0 7 7 7 0 TACI, cysteine-rich domain LNS2 PF08235.13 PIK45386.1 - 0.044 13.3 4.1 57 3.1 0.0 4.9 6 0 0 6 6 6 0 LNS2 (Lipin/Ned1/Smp2) Phage_fiber_2 PF03406.13 PIK45386.1 - 0.063 12.8 11.4 29 4.3 0.0 7.7 10 0 0 10 10 10 0 Phage tail fibre repeat DUF1583 PF07622.11 PIK45386.1 - 0.13 11.0 0.3 38 2.9 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF1583) Reg_prop PF07494.11 PIK45386.1 - 0.29 11.5 4.0 1.1e+03 0.6 0.0 7.2 7 0 0 7 7 7 0 Two component regulator propeller DUF1471 PF07338.13 PIK45386.1 - 0.65 10.0 15.7 1.5e+02 2.5 0.1 6.7 7 0 0 7 7 7 0 Protein of unknown function (DUF1471) NACHT PF05729.12 PIK45387.1 - 1.3e-08 35.0 0.0 2.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain DUF1786 PF08735.10 PIK45387.1 - 0.0045 16.3 0.0 0.34 10.2 0.0 2.2 2 0 0 2 2 2 2 Putative pyruvate format-lyase activating enzyme (DUF1786) ResIII PF04851.15 PIK45387.1 - 0.1 12.6 1.0 0.29 11.1 0.7 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit VapB_antitoxin PF09957.9 PIK45388.1 - 0.055 13.4 0.2 0.22 11.5 0.0 2.1 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB SAM_1 PF00536.30 PIK45388.1 - 0.13 12.8 0.1 0.43 11.1 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) zf-CCHC_4 PF14392.6 PIK45389.1 - 8.1e-07 28.7 12.3 0.0079 15.9 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 PIK45389.1 - 4.9e-06 26.4 16.1 0.002 18.1 3.3 3.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45389.1 - 0.0019 18.0 0.2 0.0019 18.0 0.2 2.8 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK45389.1 - 0.94 9.8 13.0 0.33 11.2 6.9 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK45389.1 - 1.1 9.0 12.9 0.57 10.0 0.3 4.1 4 0 0 4 4 4 0 C2H2 zinc-finger Transposase_21 PF02992.14 PIK45390.1 - 0.00031 20.0 0.0 0.00068 18.9 0.0 1.5 1 0 0 1 1 1 1 Transposase family tnp2 zf-C2H2_aberr PF17017.5 PIK45390.1 - 0.15 12.2 1.4 0.46 10.6 0.4 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger RVT_1 PF00078.27 PIK45393.1 - 1.3e-18 67.3 0.0 2e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4665 PF15679.5 PIK45393.1 - 0.048 14.3 0.3 0.12 13.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) TPR_MLP1_2 PF07926.12 PIK45395.1 - 0.0011 19.1 3.4 0.0014 18.7 2.4 1.7 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 PIK45395.1 - 0.0016 17.8 0.8 0.0023 17.3 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) TSC22 PF01166.18 PIK45395.1 - 0.0022 18.3 1.9 0.0044 17.3 1.9 1.5 1 0 0 1 1 1 1 TSC-22/dip/bun family EzrA PF06160.12 PIK45395.1 - 0.0024 16.2 0.5 0.0027 15.9 0.5 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Tropomyosin PF00261.20 PIK45395.1 - 0.017 14.5 1.1 0.021 14.2 1.1 1.1 1 0 0 1 1 1 0 Tropomyosin Nnf1 PF03980.14 PIK45395.1 - 0.034 14.5 2.2 0.039 14.3 1.2 1.7 2 1 0 2 2 1 0 Nnf1 ADIP PF11559.8 PIK45395.1 - 0.034 14.2 3.3 0.05 13.7 3.3 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.15 PIK45395.1 - 0.037 13.8 1.1 0.31 10.8 2.3 1.9 2 1 0 2 2 2 0 Septum formation initiator Spc7 PF08317.11 PIK45395.1 - 0.042 12.7 1.8 0.055 12.4 1.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Pox_A_type_inc PF04508.12 PIK45395.1 - 0.065 13.1 0.4 0.065 13.1 0.4 1.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Csm1_N PF18504.1 PIK45395.1 - 0.14 12.5 2.6 0.38 11.1 1.5 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain Chibby PF14645.6 PIK45395.1 - 0.15 12.4 1.2 0.24 11.8 1.2 1.4 1 0 0 1 1 1 0 Chibby family Herpes_UL6 PF01763.16 PIK45395.1 - 0.16 10.4 0.2 0.19 10.2 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like SlyX PF04102.12 PIK45395.1 - 0.23 12.1 4.9 0.21 12.2 2.2 2.3 2 1 0 2 2 2 0 SlyX DASH_Dam1 PF08653.10 PIK45395.1 - 0.37 10.6 1.4 11 5.9 0.4 2.4 1 1 1 2 2 2 0 DASH complex subunit Dam1 FAM76 PF16046.5 PIK45395.1 - 0.44 9.9 0.8 0.63 9.3 0.8 1.2 1 0 0 1 1 1 0 FAM76 protein bZIP_1 PF00170.21 PIK45395.1 - 0.51 10.5 2.7 1.2 9.2 2.7 1.6 1 1 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 PIK45395.1 - 0.62 10.2 3.9 2.4 8.3 3.9 2.0 1 1 0 1 1 1 0 Basic region leucine zipper ZapB PF06005.12 PIK45395.1 - 0.71 10.3 5.8 2.3 8.7 4.5 2.3 2 1 0 2 2 2 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 PIK45395.1 - 2.1 8.4 7.8 0.73 9.9 1.9 2.8 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding zf-RVT PF13966.6 PIK45396.1 - 4.4e-06 27.3 3.1 4.4e-06 27.3 3.1 1.8 2 1 0 2 2 2 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK45397.1 - 1.1e-37 129.7 0.1 1.4e-37 129.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK45398.1 - 1.1e-05 25.3 9.4 0.019 15.0 0.1 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45398.1 - 0.00052 19.7 11.0 0.36 10.6 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45398.1 - 0.012 15.4 1.6 0.012 15.4 1.6 2.9 3 0 0 3 3 3 0 Zinc knuckle zf-RVT PF13966.6 PIK45399.1 - 1.6e-06 28.7 0.8 1.6e-06 28.7 0.8 2.3 3 1 0 3 3 3 1 zinc-binding in reverse transcriptase LssY_C PF14067.6 PIK45399.1 - 0.21 11.1 2.8 0.34 10.4 2.8 1.2 1 0 0 1 1 1 0 LssY C-terminus RVT_1 PF00078.27 PIK45400.1 - 1.1e-37 129.7 0.1 1.4e-37 129.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK45401.1 - 9.5e-14 51.5 0.1 1.4e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK45401.1 - 0.068 13.0 0.1 0.22 11.4 0.0 2.0 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase Peptidase_S3 PF00944.19 PIK45401.1 - 0.16 11.8 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 Alphavirus core protein zf-CCHC PF00098.23 PIK45402.1 - 3.4e-06 26.9 9.4 0.011 15.7 0.1 3.3 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45402.1 - 0.00012 21.8 10.9 0.22 11.3 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45402.1 - 0.0075 16.1 1.5 0.0075 16.1 1.5 3.0 3 0 0 3 3 3 2 Zinc knuckle bZIP_Maf PF03131.17 PIK45403.1 - 0.0019 18.7 3.8 0.0019 18.7 3.8 2.3 2 0 0 2 2 2 1 bZIP Maf transcription factor RVT_1 PF00078.27 PIK45404.1 - 4.4e-34 117.9 0.0 7.8e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK45404.1 - 3.4e-10 40.5 0.8 1.4e-09 38.5 0.8 2.1 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK45405.1 - 4.2e-41 140.9 0.0 6.8e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRA-CH PF01502.18 PIK45405.1 - 0.12 12.3 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosyl-AMP cyclohydrolase zf-CCHC PF00098.23 PIK45406.1 - 1.3e-06 28.1 25.7 0.0042 17.1 1.8 4.7 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45406.1 - 0.0011 18.7 1.9 0.0011 18.7 1.9 3.7 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45406.1 - 0.0099 15.6 22.3 0.24 11.2 0.5 3.8 3 1 1 4 4 4 3 Zinc knuckle zf-CCHC PF00098.23 PIK45407.1 - 1.5e-07 31.1 12.7 0.019 15.0 0.3 3.4 3 0 0 3 3 3 3 Zinc knuckle DUF4258 PF14076.6 PIK45407.1 - 0.094 13.1 0.6 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4258) zf-CCHC_4 PF14392.6 PIK45407.1 - 0.36 10.6 15.0 1.1 9.0 1.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK45407.1 - 4.3 7.4 16.9 8.4 6.4 2.9 3.5 1 1 2 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK45408.1 - 5.8e-25 88.1 0.1 7.6e-24 84.5 0.1 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK45409.1 - 1.9e-40 138.7 0.1 3.3e-40 138.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK45409.1 - 9e-07 29.5 0.7 3.4e-06 27.7 0.7 2.1 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-CCHC PF00098.23 PIK45411.1 - 4.2e-11 42.4 20.0 1.6e-05 24.8 0.4 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45411.1 - 0.00016 21.4 14.2 0.17 11.7 2.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45411.1 - 6.4 6.7 17.1 0.62 9.9 0.8 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC PF00098.23 PIK45412.1 - 1.5e-11 43.8 16.4 1.3e-05 25.1 0.8 3.8 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45412.1 - 0.0016 18.1 16.5 0.029 14.1 0.9 3.5 2 1 1 3 3 3 3 Zinc knuckle RRM_3 PF08777.11 PIK45412.1 - 0.0082 16.2 0.0 0.36 10.9 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif zf-CCHC_5 PF14787.6 PIK45412.1 - 0.54 10.0 10.8 0.37 10.5 0.4 3.1 1 1 2 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK45412.1 - 0.69 9.9 16.4 0.83 9.7 0.8 3.5 1 1 2 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK45413.1 - 6.6e-35 120.6 0.0 9.7e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK45414.1 - 5.8e-41 140.4 0.1 7.6e-41 140.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK45415.1 - 1.1e-05 25.3 9.4 0.019 15.0 0.1 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45415.1 - 0.00052 19.7 11.0 0.36 10.6 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45415.1 - 0.012 15.4 1.6 0.012 15.4 1.6 2.9 3 0 0 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK45416.1 - 8.2e-41 139.9 0.1 1.1e-40 139.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK45417.1 - 0.00086 18.9 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 PIK45418.1 - 9.3e-08 31.8 25.7 0.0019 18.2 1.8 4.5 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45418.1 - 0.00046 19.9 21.7 0.11 12.3 0.5 3.9 3 1 1 4 4 4 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45418.1 - 0.00051 19.8 1.9 0.00051 19.8 1.9 3.4 3 0 0 3 3 3 1 Zinc knuckle Phage_tail_3 PF08813.11 PIK45418.1 - 0.056 13.1 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Phage tail tube protein, TTP RVT_1 PF00078.27 PIK45419.1 - 7.2e-41 140.1 0.1 9.5e-41 139.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK45420.1 - 1.1e-06 29.3 1.7 1.1e-06 29.3 1.7 2.1 2 1 0 2 2 2 1 zinc-binding in reverse transcriptase LssY_C PF14067.6 PIK45420.1 - 0.044 13.3 2.3 0.068 12.7 2.3 1.2 1 0 0 1 1 1 0 LssY C-terminus Exo_endo_phos PF03372.23 PIK45421.1 - 0.00027 20.5 0.1 0.00043 19.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK45421.1 - 0.053 13.4 0.2 0.17 11.8 0.0 2.0 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase Peptidase_S3 PF00944.19 PIK45421.1 - 0.17 11.7 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Alphavirus core protein zf-CCHC PF00098.23 PIK45422.1 - 4.4e-06 26.5 9.4 0.013 15.5 0.1 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45422.1 - 0.00017 21.3 10.9 0.25 11.1 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45422.1 - 0.0087 15.9 1.5 0.0087 15.9 1.5 3.0 3 0 0 3 3 3 2 Zinc knuckle SRCR PF00530.18 PIK45423.1 - 1.5e-58 195.5 7.8 1.6e-30 105.6 1.6 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK45423.1 - 1.7e-15 57.3 3.4 3.4e-07 30.7 0.2 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK45423.1 - 3.4e-09 37.2 0.5 0.0043 17.5 0.0 2.6 2 1 0 2 2 2 2 Hepsin, SRCR domain RRF PF01765.19 PIK45424.1 - 2.2e-45 154.5 4.6 3.9e-45 153.7 4.6 1.4 1 0 0 1 1 1 1 Ribosome recycling factor Spectrin_like PF18373.1 PIK45424.1 - 0.07 13.2 0.2 5 7.3 0.1 2.6 2 0 0 2 2 2 0 Spectrin like domain UNC-79 PF14776.6 PIK45426.1 - 3.1e-176 587.2 2.5 3.8e-176 586.9 2.5 1.0 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 ADAM_spacer1 PF05986.14 PIK45427.1 - 7e-11 42.2 0.0 0.00046 20.2 0.0 2.4 1 1 1 2 2 2 2 ADAM-TS Spacer 1 TSP_1 PF00090.19 PIK45427.1 - 1.8e-09 37.6 5.6 5e-09 36.3 5.6 1.7 1 0 0 1 1 1 1 Thrombospondin type 1 domain ATP-grasp_5 PF13549.6 PIK45427.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain PLAC PF08686.11 PIK45428.1 - 1.4e-09 38.5 14.7 2.6e-09 37.6 13.3 2.3 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain TSP_1 PF00090.19 PIK45428.1 - 4e-05 23.7 15.9 0.0018 18.5 0.4 6.6 6 1 0 6 6 6 3 Thrombospondin type 1 domain zf-MYND PF01753.18 PIK45429.1 - 0.00044 20.3 15.8 0.0011 19.0 15.8 1.7 1 0 0 1 1 1 1 MYND finger DUF3268 PF11672.8 PIK45429.1 - 0.3 11.4 6.8 0.65 10.3 6.8 1.5 1 0 0 1 1 1 0 zinc-finger-containing domain MFS_1 PF07690.16 PIK45432.1 - 1.2e-33 116.5 21.4 1.2e-33 116.5 21.4 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK45432.1 - 3.2e-19 69.1 10.2 2.9e-18 66.0 3.1 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 PIK45432.1 - 1.7 6.8 17.5 9.4 4.4 12.1 3.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DS PF01916.17 PIK45433.1 - 2e-38 132.3 0.1 2.3e-38 132.1 0.1 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase DS PF01916.17 PIK45434.1 - 1.4e-55 188.6 0.0 1.7e-55 188.3 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase Synaptobrevin PF00957.21 PIK45435.1 - 4.1e-30 103.4 0.2 5.7e-30 103.0 0.2 1.2 1 0 0 1 1 1 1 Synaptobrevin Ferlin_C PF16165.5 PIK45435.1 - 0.017 15.1 0.0 0.017 15.1 0.0 1.5 2 0 0 2 2 2 0 Ferlin C-terminus EMC3_TMCO1 PF01956.16 PIK45436.1 - 2.6e-36 124.9 2.1 2.9e-36 124.8 2.1 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DivIC PF04977.15 PIK45436.1 - 0.0027 17.4 0.9 0.0046 16.7 0.9 1.4 1 0 0 1 1 1 1 Septum formation initiator MIF4G_like_2 PF09090.11 PIK45436.1 - 0.013 15.0 0.4 0.016 14.7 0.4 1.1 1 0 0 1 1 1 0 MIF4G like Nucleoside_tran PF01733.18 PIK45436.1 - 0.046 13.1 4.2 0.032 13.6 2.1 1.6 1 1 1 2 2 2 0 Nucleoside transporter GWT1 PF06423.12 PIK45436.1 - 0.055 13.6 0.8 0.096 12.8 0.8 1.5 1 1 0 1 1 1 0 GWT1 Stevor PF17410.2 PIK45436.1 - 0.079 12.5 1.8 0.11 12.0 1.8 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame XhlA PF10779.9 PIK45436.1 - 7.8 6.8 6.1 3.9 7.8 0.5 2.4 1 1 1 2 2 2 0 Haemolysin XhlA Prenyltrans PF00432.21 PIK45437.1 - 1.7e-12 46.9 0.0 1.4e-09 37.5 0.0 3.1 3 0 0 3 3 3 2 Prenyltransferase and squalene oxidase repeat Adenine_deam_C PF13382.6 PIK45437.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain Prenyltrans PF00432.21 PIK45438.1 - 2.4e-47 158.3 1.9 2.4e-13 49.5 0.0 4.1 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat V_ATPase_I PF01496.19 PIK45439.1 - 9e-78 262.1 0.3 3e-77 260.3 0.2 1.6 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family CheZ PF04344.13 PIK45439.1 - 0.08 12.8 0.5 0.18 11.7 0.1 1.6 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ V_ATPase_I PF01496.19 PIK45440.1 - 2.4e-66 224.3 0.0 2.7e-66 224.1 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family KASH_CCD PF14662.6 PIK45440.1 - 0.0066 16.3 1.1 0.011 15.6 0.6 1.6 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH Spore_III_AB PF09548.10 PIK45440.1 - 0.01 16.0 1.0 0.018 15.1 1.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Occludin_ELL PF07303.13 PIK45440.1 - 0.18 12.5 2.2 18 6.1 0.3 2.3 2 0 0 2 2 2 0 Occludin homology domain DHR10 PF18595.1 PIK45440.1 - 0.27 11.3 5.2 0.97 9.5 2.7 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Filament PF00038.21 PIK45440.1 - 0.34 10.4 5.4 1.4 8.4 0.8 2.0 1 1 1 2 2 2 0 Intermediate filament protein ERM PF00769.19 PIK45441.1 - 1e-05 25.5 79.3 6.1e-05 23.0 37.4 2.0 1 1 1 2 2 2 2 Ezrin/radixin/moesin family GAS PF13851.6 PIK45441.1 - 8.4e-05 22.0 42.7 0.00059 19.2 40.2 2.7 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK45441.1 - 0.00018 22.0 51.4 0.04 14.4 31.6 2.8 1 1 2 3 3 3 3 Apg6 coiled-coil region DUF4472 PF14739.6 PIK45441.1 - 0.0084 16.8 36.2 0.25 12.1 13.6 3.8 1 1 3 4 4 4 2 Domain of unknown function (DUF4472) CDH PF02611.15 PIK45441.1 - 0.016 14.8 1.0 0.016 14.8 1.0 2.0 1 1 1 2 2 2 0 CDP-diacylglycerol pyrophosphatase KASH_CCD PF14662.6 PIK45441.1 - 0.03 14.2 46.1 0.61 9.9 26.7 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Suppressor_APC PF11414.8 PIK45441.1 - 0.047 13.8 28.2 0.036 14.1 6.8 3.4 1 1 2 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Myosin_tail_1 PF01576.19 PIK45441.1 - 0.083 10.7 41.9 0.1 10.4 41.9 1.1 1 0 0 1 1 1 0 Myosin tail TACC_C PF05010.14 PIK45441.1 - 0.11 12.2 35.5 0.19 11.5 35.5 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Cep57_MT_bd PF06657.13 PIK45441.1 - 0.11 12.9 29.7 0.61 10.6 5.7 4.2 1 1 3 4 4 4 0 Centrosome microtubule-binding domain of Cep57 DUF4164 PF13747.6 PIK45441.1 - 0.12 12.6 29.5 0.29 11.4 7.6 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) CALCOCO1 PF07888.11 PIK45441.1 - 0.15 10.9 41.5 0.19 10.6 41.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like EzrA PF06160.12 PIK45441.1 - 0.19 9.9 30.4 0.23 9.6 30.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Caldesmon PF02029.15 PIK45441.1 - 0.3 9.8 33.8 0.37 9.5 33.8 1.1 1 0 0 1 1 1 0 Caldesmon SKA2 PF16740.5 PIK45441.1 - 0.35 10.7 30.5 0.17 11.7 8.0 3.2 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 Spc7 PF08317.11 PIK45441.1 - 0.36 9.7 42.2 0.19 10.6 30.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein T2SSN PF01203.19 PIK45441.1 - 0.4 10.9 4.5 0.52 10.5 2.7 1.9 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein N CENP-F_leu_zip PF10473.9 PIK45441.1 - 0.49 10.4 44.7 5.8 6.9 26.7 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 PIK45441.1 - 0.71 10.1 47.7 0.2 11.8 23.7 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Sec20 PF03908.13 PIK45441.1 - 1.1 9.2 19.4 3.7 7.5 1.5 3.7 1 1 2 3 3 3 0 Sec20 FlgN PF05130.12 PIK45441.1 - 1.2 9.6 40.7 5.9 7.4 18.3 3.2 1 1 1 2 2 2 0 FlgN protein Sipho_Gp157 PF05565.11 PIK45441.1 - 2.3 8.2 28.8 0.98 9.4 9.4 3.0 1 1 1 2 2 2 0 Siphovirus Gp157 Mce4_CUP1 PF11887.8 PIK45441.1 - 2.9 7.3 10.0 2.1 7.7 5.5 2.2 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Fez1 PF06818.15 PIK45441.1 - 4.2 7.8 41.6 2.6 8.5 28.5 2.1 1 1 1 2 2 2 0 Fez1 ADIP PF11559.8 PIK45441.1 - 4.9 7.2 46.0 4.9 7.2 18.4 2.7 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.8 PIK45441.1 - 5.7 4.3 40.7 13 3.1 40.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) SAM_KSR1 PF13543.6 PIK45441.1 - 6.5 6.9 17.9 1.5 9.0 2.4 3.1 1 1 3 4 4 4 0 SAM like domain present in kinase suppressor RAS 1 HIP1_clath_bdg PF16515.5 PIK45441.1 - 6.8 7.4 46.8 2.9 8.6 14.2 3.2 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPD52 PF04201.15 PIK45441.1 - 7.1 6.2 39.5 1.5 8.4 11.3 3.2 1 1 2 3 3 3 0 Tumour protein D52 family FPP PF05911.11 PIK45441.1 - 7.6 4.6 40.4 38 2.3 40.4 1.9 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Fib_alpha PF08702.10 PIK45441.1 - 8.5 6.5 27.3 0.47 10.6 4.0 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Occludin_ELL PF07303.13 PIK45441.1 - 9.1 7.1 23.2 5.9 7.7 11.8 2.6 1 1 1 2 2 2 0 Occludin homology domain Golgin_A5 PF09787.9 PIK45441.1 - 9.5 5.6 42.7 7.3 6.0 22.5 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 ZU5 PF00791.20 PIK45442.1 - 2.7e-10 40.5 0.1 9.2e-10 38.8 0.1 1.9 1 0 0 1 1 1 1 ZU5 domain bPH_5 PF10882.8 PIK45442.1 - 0.0044 17.1 0.0 0.0087 16.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial PH domain DED PF01335.21 PIK45442.1 - 0.022 15.1 0.3 0.053 13.8 0.3 1.7 1 0 0 1 1 1 0 Death effector domain APG6_N PF17675.1 PIK45443.1 - 2.4e-11 44.3 114.0 0.0026 18.3 19.9 5.3 1 1 3 4 4 4 3 Apg6 coiled-coil region ERM PF00769.19 PIK45443.1 - 1.7e-09 37.9 112.7 0.00055 19.8 35.6 4.0 1 1 3 4 4 4 4 Ezrin/radixin/moesin family GAS PF13851.6 PIK45443.1 - 2.2e-08 33.7 97.4 0.0014 18.0 21.2 4.6 1 1 4 5 5 5 5 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 PIK45443.1 - 8.5e-05 23.1 99.4 0.043 14.4 16.4 5.5 2 1 2 5 5 5 3 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4472 PF14739.6 PIK45443.1 - 0.00046 20.9 84.9 0.59 10.9 14.2 5.9 1 1 6 7 7 7 4 Domain of unknown function (DUF4472) PilA4 PF18682.1 PIK45443.1 - 0.0025 18.2 25.6 7.8 6.9 0.2 7.7 2 1 3 7 7 7 1 Pilin A4 KASH_CCD PF14662.6 PIK45443.1 - 0.0026 17.6 102.4 0.0062 16.4 10.9 6.1 1 1 4 6 6 6 4 Coiled-coil region of CCDC155 or KASH DUF1495 PF07381.11 PIK45443.1 - 0.076 12.8 2.4 20 5.1 0.0 4.4 3 2 2 6 6 6 0 Winged helix DNA-binding domain (DUF1495) DUF150_C PF17384.2 PIK45443.1 - 0.089 12.9 42.4 5.6 7.2 0.2 9.2 2 2 7 9 9 9 0 RimP C-terminal SH3 domain FliT PF05400.13 PIK45443.1 - 0.11 13.3 73.2 0.2 12.5 9.6 8.6 1 1 4 6 6 5 0 Flagellar protein FliT Fez1 PF06818.15 PIK45443.1 - 0.12 12.8 90.8 12 6.3 37.8 3.8 1 1 2 3 3 3 0 Fez1 SOGA PF11365.8 PIK45443.1 - 0.14 13.3 76.8 2 9.6 15.4 4.8 1 1 4 5 5 5 0 Protein SOGA Lebercilin PF15619.6 PIK45443.1 - 0.52 9.9 96.9 9.5 5.8 11.0 5.1 1 1 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease T3SSipB PF16535.5 PIK45443.1 - 1.1 9.8 54.9 2.2 8.8 11.0 4.6 1 1 3 4 4 4 0 Type III cell invasion protein SipB CALCOCO1 PF07888.11 PIK45443.1 - 1.2 7.9 100.6 0.18 10.6 15.2 3.2 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 PIK45443.1 - 2.4 8.2 101.7 0.51 10.3 11.5 4.7 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rab5-bind PF09311.11 PIK45443.1 - 2.6 7.4 76.2 4.9 6.5 21.5 3.5 1 1 2 3 3 3 0 Rabaptin-like protein DUF1664 PF07889.12 PIK45443.1 - 3.2 7.8 51.8 2 8.5 5.6 5.3 1 1 6 7 7 7 0 Protein of unknown function (DUF1664) GD_N PF16030.5 PIK45443.1 - 3.7 7.9 26.5 6.2 7.2 0.9 5.4 1 1 4 6 6 6 0 Serine protease gd N-terminus FmiP_Thoc5 PF09766.9 PIK45443.1 - 7.7 5.7 90.5 1.6 8.0 18.7 5.1 1 1 5 6 6 6 0 Fms-interacting protein/Thoc5 TACC_C PF05010.14 PIK45443.1 - 10 5.9 80.4 1.4 8.6 26.3 3.7 1 1 3 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal NSP2_assoc PF14758.6 PIK45444.1 - 0.059 13.7 0.1 0.072 13.4 0.1 1.1 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein ZU5 PF00791.20 PIK45445.1 - 5.2e-11 42.7 0.1 1.6e-10 41.2 0.1 1.8 1 0 0 1 1 1 1 ZU5 domain Noggin PF05806.12 PIK45446.1 - 7.8e-34 117.5 17.5 3.2e-33 115.5 17.5 1.8 1 1 0 1 1 1 1 Noggin Coilin_N PF15862.5 PIK45447.1 - 6.2e-18 64.9 9.5 6.2e-18 64.9 9.5 3.5 3 1 1 4 4 4 2 Coilin N-terminus SNF2_N PF00176.23 PIK45448.1 - 6.6e-70 235.6 0.1 1.1e-69 234.8 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK45448.1 - 3.8e-20 72.3 0.0 3.3e-19 69.3 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Allexi_40kDa PF05549.11 PIK45449.1 - 2 7.8 7.7 0.15 11.6 2.5 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein COX6B PF02297.17 PIK45450.1 - 1.4e-18 66.8 8.0 1.7e-18 66.6 8.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 PIK45450.1 - 0.56 10.2 3.2 0.51 10.3 2.4 1.4 1 1 0 1 1 1 0 APOBEC-like C-terminal domain DUF4457 PF14652.6 PIK45451.1 - 4.7e-210 696.5 0.3 9.2e-143 475.4 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4457) Sad1_UNC PF07738.13 PIK45451.1 - 3.1e-05 24.0 0.0 28 4.7 0.0 5.6 5 0 0 5 5 5 3 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 PIK45451.1 - 0.034 14.3 0.2 0.44 10.7 0.1 2.9 3 0 0 3 3 3 0 F5/8 type C domain LRR_8 PF13855.6 PIK45452.1 - 1.1e-52 175.6 39.3 5.1e-15 55.0 2.7 7.8 3 3 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK45452.1 - 3.4e-25 87.7 45.1 1.2e-05 25.5 1.4 8.1 5 3 3 9 9 9 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK45452.1 - 1.9e-21 76.3 2.7 2e-08 34.2 0.1 3.3 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK45452.1 - 1.8e-12 46.0 33.3 0.071 13.7 0.8 11.6 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK45452.1 - 2.1e-10 40.4 15.5 0.00038 20.0 0.2 4.9 1 1 4 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 PIK45452.1 - 1.3e-07 31.1 26.9 0.78 10.0 0.1 9.3 9 0 0 9 9 9 4 Leucine Rich repeat LRRNT PF01462.18 PIK45452.1 - 3e-05 23.6 0.2 6.4e-05 22.5 0.2 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain CRT10 PF08728.10 PIK45452.1 - 0.011 13.9 0.1 0.017 13.3 0.1 1.2 1 0 0 1 1 1 0 CRT10 LRR_8 PF13855.6 PIK45453.1 - 4.9e-24 83.9 17.6 7.9e-13 48.0 4.1 3.5 2 1 1 3 3 3 3 Leucine rich repeat TIR PF01582.20 PIK45453.1 - 1.4e-17 64.0 0.0 2.1e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK45453.1 - 9.7e-16 58.4 0.0 2.2e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 PIK45453.1 - 2.2e-11 43.8 16.6 1e-05 25.8 2.9 3.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK45453.1 - 3.3e-07 30.3 0.2 6.8e-06 26.1 0.2 2.4 3 0 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK45453.1 - 8.4e-06 25.4 2.9 0.0064 16.0 0.2 2.2 1 1 1 2 2 2 2 Leucine-rich repeat DUF1863 PF08937.11 PIK45453.1 - 7.8e-05 23.0 0.1 0.00017 21.9 0.1 1.6 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) LRR_1 PF00560.33 PIK45453.1 - 0.00037 20.6 18.3 0.39 11.4 0.4 6.5 4 2 0 4 4 4 1 Leucine Rich Repeat LRR_3 PF07725.12 PIK45453.1 - 0.14 12.1 0.2 0.14 12.1 0.2 2.8 3 0 0 3 3 3 0 Leucine Rich Repeat ECSIT PF06239.11 PIK45454.1 - 3.3e-75 252.0 3.8 8.3e-75 250.8 2.7 1.8 2 0 0 2 2 2 1 Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C PF14784.6 PIK45454.1 - 8.2e-32 110.3 0.1 3.9e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 C-terminal domain of the ECSIT protein PPR_3 PF13812.6 PIK45454.1 - 0.048 13.7 0.1 4.4 7.5 0.0 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Transglut_i_TM PF14400.6 PIK45454.1 - 0.063 13.3 0.9 0.14 12.2 0.9 1.5 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices Metallophos PF00149.28 PIK45455.1 - 2.1e-18 67.5 1.0 1.3e-17 65.0 1.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK45455.1 - 1.8e-05 25.0 0.0 0.079 13.2 1.5 2.2 1 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain BTB PF00651.31 PIK45456.1 - 2.2e-23 82.6 0.0 5.1e-14 52.4 0.0 3.2 2 1 0 2 2 2 2 BTB/POZ domain HBS1_N PF08938.10 PIK45456.1 - 0.0057 16.9 0.2 0.029 14.7 0.0 2.3 2 0 0 2 2 2 1 HBS1 N-terminus RXLR_WY PF18634.1 PIK45456.1 - 0.018 15.0 0.3 0.43 10.6 0.1 2.6 2 0 0 2 2 2 0 RXLR phytopathogen effector protein WY-domain Dna2 PF08696.11 PIK45456.1 - 0.1 12.4 3.0 0.42 10.4 2.3 2.2 2 1 0 2 2 2 0 DNA replication factor Dna2 UBA_4 PF14555.6 PIK45456.1 - 0.14 12.0 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 UBA-like domain tRNA-synt_1b PF00579.25 PIK45457.1 - 8.2e-52 176.3 0.0 4.4e-28 98.5 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) FAD_binding_1 PF00667.20 PIK45457.1 - 0.027 14.1 0.3 0.045 13.3 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain MethyltransfD12 PF02086.15 PIK45457.1 - 0.042 13.5 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase S4 PF01479.25 PIK45457.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 S4 domain BRE1 PF08647.11 PIK45458.1 - 1.1e-16 60.7 18.1 1.1e-16 60.7 18.1 9.5 3 2 8 11 11 11 4 BRE1 E3 ubiquitin ligase Yqai PF09466.10 PIK45458.1 - 0.044 14.1 0.0 0.16 12.3 0.0 2.1 1 1 0 1 1 1 0 Hypothetical protein Yqai Filament PF00038.21 PIK45459.1 - 0.00025 20.7 42.9 0.00034 20.3 42.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Atg14 PF10186.9 PIK45459.1 - 0.014 14.5 38.5 0.083 12.0 17.8 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pox_F11 PF04943.12 PIK45459.1 - 0.24 10.4 11.2 0.34 9.9 11.2 1.2 1 0 0 1 1 1 0 Poxvirus F11 protein Phage_HK97_TLTM PF06120.11 PIK45459.1 - 0.62 9.2 33.6 0.44 9.7 7.8 3.2 1 1 1 3 3 3 0 Tail length tape measure protein UPF0242 PF06785.11 PIK45459.1 - 0.89 9.6 51.1 0.71 9.9 23.2 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 PIK45459.1 - 1.4 8.2 53.0 1.1 8.6 21.6 3.6 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK45459.1 - 1.6 9.3 53.1 0.075 13.6 12.7 3.6 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF1664 PF07889.12 PIK45459.1 - 2.4 8.2 28.5 1.8 8.6 3.8 4.1 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 PIK45459.1 - 2.9 8.3 44.6 2.9 8.3 21.7 2.5 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 PIK45459.1 - 3.9 6.3 50.0 18 4.1 23.6 3.7 1 1 2 3 3 3 0 Spc7 kinetochore protein MAD PF05557.13 PIK45459.1 - 3.9 5.7 50.5 11 4.2 48.9 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein RVT_1 PF00078.27 PIK45461.1 - 3.1e-08 33.4 0.1 4.3e-08 32.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HLH PF00010.26 PIK45463.1 - 1.1e-13 50.9 3.5 1.8e-13 50.2 3.5 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ribonuclease_P PF00825.18 PIK45463.1 - 0.0028 17.7 0.1 0.0044 17.1 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease P Dysbindin PF04440.16 PIK45463.1 - 0.034 14.3 1.7 0.076 13.2 1.7 1.5 1 0 0 1 1 1 0 Dysbindin (Dystrobrevin binding protein 1) Calpain_inhib PF00748.19 PIK45463.1 - 0.15 12.6 2.1 0.54 10.8 0.4 2.2 1 1 1 2 2 2 0 Calpain inhibitor EGF PF00008.27 PIK45464.1 - 8.2e-65 214.6 117.7 6.4e-09 35.9 9.3 9.3 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 PIK45464.1 - 2.6e-40 135.7 108.4 8.9e-08 32.5 8.6 10.6 10 0 0 10 10 10 9 Human growth factor-like EGF EGF_CA PF07645.15 PIK45464.1 - 2.7e-22 78.7 130.1 1.2e-05 25.3 7.9 9.2 6 1 3 9 9 9 7 Calcium-binding EGF domain EGF_2 PF07974.13 PIK45464.1 - 2.7e-10 40.4 143.7 0.0031 17.8 12.5 9.2 9 0 0 9 9 9 8 EGF-like domain FXa_inhibition PF14670.6 PIK45464.1 - 6.5e-07 29.5 108.5 0.025 14.8 8.7 9.8 6 3 3 9 9 9 8 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK45464.1 - 0.014 15.6 118.4 0.018 15.2 6.1 10.0 8 1 1 9 9 9 0 EGF domain EGF PF00008.27 PIK45465.1 - 1.5e-25 89.1 53.3 1.5e-10 41.2 7.7 5.2 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.7 PIK45465.1 - 1.9e-15 56.8 42.6 5.6e-06 26.8 6.3 5.8 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_CA PF07645.15 PIK45465.1 - 2.5e-11 43.6 57.0 2.4e-07 30.8 9.0 5.1 3 2 2 5 5 5 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK45465.1 - 1.1e-09 38.5 61.5 0.00033 21.0 10.6 5.2 5 0 0 5 5 5 5 EGF-like domain EGF_3 PF12947.7 PIK45465.1 - 0.00036 20.7 49.8 0.054 13.7 5.5 5.8 3 2 2 5 5 5 4 EGF domain FXa_inhibition PF14670.6 PIK45465.1 - 0.00097 19.4 47.5 0.0048 17.1 5.4 5.2 3 2 2 5 5 5 4 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 PIK45465.1 - 0.0031 17.8 7.1 0.0031 17.8 7.1 5.0 5 0 0 5 5 5 2 Pvs28 EGF domain cEGF PF12662.7 PIK45465.1 - 0.032 14.2 38.6 0.037 13.9 4.9 5.5 5 1 0 5 5 5 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK45465.1 - 2 8.6 47.0 0.52 10.5 1.8 4.6 1 1 3 4 4 4 0 Laminin EGF domain Calx-beta PF03160.14 PIK45466.1 - 1.8e-11 44.1 12.5 8.7e-07 29.0 5.8 2.7 3 0 0 3 3 3 2 Calx-beta domain GH101_N PF17995.1 PIK45466.1 - 0.0028 17.3 0.3 0.017 14.7 0.1 2.1 2 0 0 2 2 2 1 Endo-alpha-N-acetylgalactosaminidase N-terminal Pyridox_ox_2 PF12900.7 PIK45466.1 - 0.057 13.4 0.1 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase GUCT PF08152.12 PIK45467.1 - 1.8e-06 28.2 0.1 2.7e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 GUCT (NUC152) domain TRCF PF03461.15 PIK45467.1 - 0.095 13.1 0.0 0.33 11.3 0.0 1.8 1 1 0 1 1 1 0 TRCF domain DUF4907 PF16250.5 PIK45469.1 - 0.083 12.8 0.7 0.17 11.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4907) WW_FCH_linker PF16623.5 PIK45469.1 - 0.094 13.5 0.2 0.094 13.5 0.2 1.9 2 0 0 2 2 2 0 Unstructured linker region between on GAS7 protein CLCA PF08434.11 PIK45470.1 - 8.6e-29 100.7 0.1 9.4e-29 100.5 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal DnaJ PF00226.31 PIK45470.1 - 0.045 13.9 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 DnaJ domain CLCA PF08434.11 PIK45471.1 - 7.4e-14 51.7 0.3 1.5e-13 50.7 0.1 1.5 2 0 0 2 2 2 1 Calcium-activated chloride channel N terminal VWA_2 PF13519.6 PIK45471.1 - 4.8e-06 27.2 0.0 1.3e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain 1-cysPrx_C PF10417.9 PIK45471.1 - 0.016 15.1 1.1 0.029 14.2 0.1 1.9 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin DUF1194 PF06707.11 PIK45471.1 - 0.033 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) VWA_2 PF13519.6 PIK45473.1 - 4.9e-12 46.4 0.2 9.1e-12 45.6 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK45473.1 - 8.6e-12 45.6 0.3 1.7e-11 44.7 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK45473.1 - 4e-10 39.5 0.2 6.9e-10 38.7 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CLCA PF08434.11 PIK45473.1 - 1.3e-06 28.0 0.1 2.1e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal DUF1194 PF06707.11 PIK45473.1 - 0.00034 19.9 0.3 0.00077 18.7 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1194) vWA-TerF-like PF10138.9 PIK45473.1 - 0.021 14.9 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus DUF4625 PF15418.6 PIK45473.1 - 0.042 14.1 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) TMEM154 PF15102.6 PIK45473.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Podoplanin PF05808.11 PIK45473.1 - 0.065 13.3 3.0 0.2 11.7 3.0 1.8 1 0 0 1 1 1 0 Podoplanin RE_BsaWI PF18643.1 PIK45473.1 - 0.16 11.9 0.0 0.52 10.2 0.0 1.8 2 0 0 2 2 2 0 BsaWI restriction endonuclease type 2 MGC-24 PF05283.11 PIK45473.1 - 0.29 11.6 2.8 0.23 11.9 1.1 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin EamA PF00892.20 PIK45474.1 - 8.4e-19 68.1 34.9 2.2e-12 47.3 15.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family PDZ_6 PF17820.1 PIK45475.1 - 6.9e-09 35.4 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK45475.1 - 2.9e-07 30.7 0.1 4.8e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_1 PF12812.7 PIK45475.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 PDZ-like domain SH3_9 PF14604.6 PIK45476.1 - 9.5e-35 118.2 1.3 2.1e-16 59.5 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 PIK45476.1 - 1.3e-34 117.5 4.2 2.3e-11 43.1 0.0 3.7 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.17 PIK45476.1 - 2.5e-25 87.9 0.0 2.3e-08 33.6 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.16 PIK45476.1 - 1.4e-20 72.8 0.9 4e-20 71.4 0.9 1.8 1 0 0 1 1 1 1 Sorbin homologous domain AvrPphF-ORF-2 PF09143.10 PIK45477.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 AvrPphF-ORF-2 Peptidase_M14 PF00246.24 PIK45478.1 - 2.1e-74 250.9 0.0 4.3e-74 249.9 0.0 1.5 2 0 0 2 2 2 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 PIK45478.1 - 5.2e-14 52.3 0.1 1.1e-13 51.2 0.0 1.6 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 PIK45478.1 - 2.5e-07 30.6 0.0 6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 PIK45478.1 - 0.045 12.8 0.3 0.12 11.4 0.3 1.6 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family FancD2 PF14631.6 PIK45479.1 - 4.5e-176 587.8 6.0 5.5e-176 587.5 6.0 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease DUF913 PF06025.12 PIK45479.1 - 0.18 10.7 11.4 0.18 10.7 0.7 2.8 2 1 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 PIK45479.1 - 0.24 10.8 6.1 2.3 7.6 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Cytomega_UL84 PF06284.11 PIK45479.1 - 1.3 7.4 5.1 2.5 6.4 5.1 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PPP4R2 PF09184.11 PIK45479.1 - 1.4 8.4 13.4 1 8.9 4.9 2.3 2 0 0 2 2 2 0 PPP4R2 FAM176 PF14851.6 PIK45479.1 - 2.1 8.0 12.7 4.9 6.8 3.6 2.5 2 0 0 2 2 2 0 FAM176 family FYDLN_acid PF09538.10 PIK45479.1 - 6.1 7.6 14.6 10 6.9 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 PIK45479.1 - 6.4 7.2 7.8 24 5.3 0.3 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 PIK45479.1 - 6.4 5.9 9.0 1.2 8.3 2.4 2.4 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Sigma70_ner PF04546.13 PIK45479.1 - 8.2 6.2 13.5 16 5.3 0.3 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Sacchrp_dh_C PF16653.5 PIK45480.1 - 5.8e-26 92.2 0.0 6.3e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 PIK45481.1 - 1.7e-08 34.8 0.0 3.5e-05 24.1 0.0 2.2 1 1 1 2 2 2 2 Saccharopine dehydrogenase NADP binding domain Sacchrp_dh_C PF16653.5 PIK45481.1 - 2.7e-06 27.7 0.0 0.0016 18.6 0.0 2.2 1 1 1 2 2 2 2 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_C PF01262.21 PIK45481.1 - 0.00015 21.2 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 PIK45481.1 - 0.035 14.2 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_N PF05222.15 PIK45482.1 - 7.9e-27 94.2 0.0 1.3e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Trypsin PF00089.26 PIK45483.1 - 4e-64 216.4 0.1 7.4e-64 215.6 0.1 1.5 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK45483.1 - 7.3e-08 33.4 0.0 1.3e-07 32.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 PIK45483.1 - 8.4e-06 26.2 0.0 1.7e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CUB PF00431.20 PIK45483.1 - 9e-06 26.0 0.0 1.7e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 CUB domain Fz PF01392.22 PIK45483.1 - 0.00038 21.0 8.8 0.0024 18.5 8.8 2.3 1 1 0 1 1 1 1 Fz domain rve PF00665.26 PIK45484.1 - 2e-23 82.8 0.0 5.2e-23 81.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain SCAN PF02023.17 PIK45484.1 - 1.8e-13 50.1 0.4 6.2e-13 48.4 0.1 2.1 2 0 0 2 2 2 1 SCAN domain rve_3 PF13683.6 PIK45484.1 - 9.1e-06 25.4 0.1 3.2e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_3 PF13917.6 PIK45484.1 - 0.0083 16.1 1.1 0.0083 16.1 1.1 1.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 PIK45484.1 - 0.01 15.9 0.5 0.019 15.1 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.6 PIK45484.1 - 0.042 14.5 0.0 0.077 13.6 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease ROS_MUCR PF05443.11 PIK45484.1 - 0.054 13.5 0.1 2.5 8.1 0.1 2.4 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein gag-asp_proteas PF13975.6 PIK45484.1 - 0.12 12.9 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease THOC7 PF05615.13 PIK45485.1 - 1.1e-34 119.5 9.8 1.3e-34 119.3 9.8 1.1 1 0 0 1 1 1 1 Tho complex subunit 7 Sec8_exocyst PF04048.14 PIK45485.1 - 0.047 13.6 2.8 0.74 9.7 0.2 2.5 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF4239 PF14023.6 PIK45485.1 - 0.27 11.0 4.3 0.21 11.3 2.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) DUF4407 PF14362.6 PIK45485.1 - 0.44 9.8 4.0 0.57 9.5 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 PIK45485.1 - 3.9 6.3 5.0 4.4 6.1 5.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.25 PIK45486.1 - 2.4e-44 151.7 0.0 3.1e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45486.1 - 1.1e-18 67.5 0.0 1.4e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK45486.1 - 1.6e-08 34.2 0.0 2.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK45486.1 - 0.0012 17.7 0.0 0.0015 17.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK45486.1 - 0.0059 16.0 0.0 0.0082 15.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK45486.1 - 0.02 14.8 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TetR_C_27 PF17935.1 PIK45486.1 - 0.067 13.3 0.1 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ESSS PF10183.9 PIK45487.1 - 5.3e-18 65.2 0.0 6.3e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) YIF1 PF03878.15 PIK45489.1 - 0.14 11.6 0.1 0.22 11.0 0.1 1.2 1 0 0 1 1 1 0 YIF1 PAD PF03068.15 PIK45489.1 - 0.2 10.6 1.3 0.32 9.9 1.3 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Arginase PF00491.21 PIK45490.1 - 2.4e-54 184.7 0.0 2.8e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Arginase family AAA PF00004.29 PIK45491.1 - 8.4e-09 35.9 0.0 2e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.27 PIK45491.1 - 0.00088 18.9 0.8 0.0022 17.6 0.8 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 PIK45491.1 - 0.0069 16.8 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 PIK45491.1 - 0.019 14.1 0.1 0.035 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Presenilin PF01080.17 PIK45491.1 - 0.19 10.4 8.6 0.11 11.2 0.6 2.2 2 0 0 2 2 2 0 Presenilin Ribosomal_L27 PF01016.19 PIK45492.1 - 1.2e-10 41.2 0.6 1.5e-10 40.9 0.6 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein SSF PF00474.17 PIK45493.1 - 1.3e-13 50.6 4.3 1.8e-13 50.2 4.3 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK45494.1 - 1.1e-21 77.3 11.1 4.7e-21 75.1 11.1 1.8 1 1 0 1 1 1 1 Sodium:solute symporter family Guanylate_cyc PF00211.20 PIK45495.1 - 1.3e-64 217.2 0.0 2.1e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 PIK45495.1 - 1e-42 146.3 0.0 1.7e-42 145.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45495.1 - 3.6e-33 115.0 0.0 5.9e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 PIK45495.1 - 1.4e-05 24.7 0.5 2.3e-05 23.9 0.5 1.3 1 0 0 1 1 1 1 Heme NO binding associated ANF_receptor PF01094.28 PIK45496.1 - 1.6e-45 155.7 0.0 2.1e-45 155.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Pyr_redox_2 PF07992.14 PIK45497.1 - 1.5e-12 47.4 0.0 1.8e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 PIK45497.1 - 0.00014 22.3 0.0 0.09 13.2 0.0 2.3 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 PIK45497.1 - 0.00032 20.9 0.0 0.00071 19.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK45497.1 - 0.014 14.7 0.0 0.042 13.1 0.0 1.7 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 PIK45497.1 - 0.017 13.8 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 PIK45497.1 - 0.021 14.8 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 PIK45497.1 - 0.024 15.2 0.0 1.8 9.2 0.1 2.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK45497.1 - 0.026 13.8 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 PIK45497.1 - 0.028 14.5 0.0 13 5.9 0.0 3.0 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase GRAM PF02893.20 PIK45498.1 - 1.1e-05 25.2 0.0 2.2e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 GRAM domain HEAT PF02985.22 PIK45499.1 - 1.2e-14 53.1 21.9 0.034 14.4 0.0 11.6 12 0 0 12 12 11 4 HEAT repeat HEAT_2 PF13646.6 PIK45499.1 - 2e-12 47.3 2.4 6.4e-06 26.5 0.0 5.8 6 1 0 6 6 6 2 HEAT repeats Cnd1 PF12717.7 PIK45499.1 - 2.7e-10 40.5 7.3 1e-05 25.7 0.0 5.7 3 2 3 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK45499.1 - 6.3e-08 33.1 1.8 12 6.6 0.0 6.7 5 2 2 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 PIK45499.1 - 7.8e-07 29.5 13.5 1.2 9.7 0.0 8.4 8 1 1 9 9 9 2 HEAT-like repeat Adaptin_N PF01602.20 PIK45499.1 - 8.2e-06 24.7 2.1 0.00045 18.9 0.0 2.9 2 1 0 2 2 2 1 Adaptin N terminal region CLASP_N PF12348.8 PIK45499.1 - 2.5e-05 24.0 6.2 0.018 14.6 0.3 4.7 5 1 0 5 5 5 2 CLASP N terminal Nipped-B_C PF12830.7 PIK45499.1 - 0.0037 17.2 0.9 12 5.7 0.1 4.8 5 0 0 5 5 5 0 Sister chromatid cohesion C-terminus Imm51 PF15595.6 PIK45499.1 - 0.015 15.3 0.1 0.047 13.6 0.1 1.9 1 0 0 1 1 1 0 Immunity protein 51 DUF3437 PF11919.8 PIK45499.1 - 0.024 14.6 0.0 5.6 6.9 0.0 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Cohesin_HEAT PF12765.7 PIK45499.1 - 0.053 13.8 0.2 0.43 10.9 0.1 2.7 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion MAP65_ASE1 PF03999.12 PIK45499.1 - 0.059 12.1 0.4 0.24 10.0 0.0 1.9 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) RTP1_C1 PF10363.9 PIK45499.1 - 0.06 13.5 0.1 11 6.2 0.0 4.1 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 PIK45499.1 - 0.53 9.8 6.0 24 4.3 0.0 4.6 4 1 1 5 5 5 0 Tti2 family Sec7_N PF12783.7 PIK45499.1 - 2.1 8.2 9.6 16 5.4 1.6 4.5 5 2 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal LUC7 PF03194.15 PIK45500.1 - 9.7e-46 156.5 0.5 1.1e-45 156.3 0.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus ERM PF00769.19 PIK45500.1 - 0.0037 17.1 2.5 0.0046 16.8 2.5 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Spc7 PF08317.11 PIK45500.1 - 0.046 12.6 1.2 0.06 12.2 1.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Globin PF00042.22 PIK45501.1 - 2.5e-12 47.3 0.2 6.6e-12 46.0 0.1 1.7 2 0 0 2 2 2 1 Globin Rax2 PF12768.7 PIK45502.1 - 0.014 14.9 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity GCV_H PF01597.19 PIK45502.1 - 0.031 14.2 0.1 0.065 13.1 0.1 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein TMEM52 PF14979.6 PIK45502.1 - 0.038 13.9 0.9 3.8 7.4 0.0 2.2 2 0 0 2 2 2 0 Transmembrane 52 RVT_1 PF00078.27 PIK45503.1 - 2.3e-30 105.8 0.2 2.8e-30 105.5 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Thiamine_BP PF01910.17 PIK45503.1 - 0.066 13.1 0.1 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Thiamine-binding protein Peptidase_C50 PF03568.17 PIK45505.1 - 7e-93 311.9 0.3 7e-93 311.9 0.3 2.1 2 0 0 2 2 2 1 Peptidase family C50 TPR_MalT PF17874.1 PIK45505.1 - 0.004 16.6 1.7 0.21 10.9 0.2 2.6 2 0 0 2 2 2 2 MalT-like TPR region CHAT PF12770.7 PIK45505.1 - 0.0064 15.9 0.0 0.017 14.6 0.0 1.7 1 0 0 1 1 1 1 CHAT domain MLD PF11647.8 PIK45506.1 - 0.0027 17.9 1.7 0.081 13.2 0.0 2.9 3 0 0 3 3 3 1 Membrane Localization Domain DIT1_PvcA PF05141.12 PIK45506.1 - 0.44 10.0 3.6 1.6 8.2 0.2 2.9 2 1 0 3 3 3 0 Pyoverdine/dityrosine biosynthesis protein DUF2284 PF10050.9 PIK45507.1 - 0.016 15.0 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) zf-CCCH_2 PF14608.6 PIK45507.1 - 0.08 13.5 1.7 0.091 13.3 0.5 1.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TMEM126 PF07114.11 PIK45508.1 - 3.4e-34 117.8 1.7 4e-34 117.6 1.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 126 zf-CCCH PF00642.24 PIK45509.1 - 1e-08 34.8 1.3 1.7e-08 34.2 1.3 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK45509.1 - 1.6e-06 27.9 4.5 2.5e-06 27.4 4.5 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 PIK45509.1 - 0.0019 17.9 1.6 0.0028 17.4 1.6 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger SR-25 PF10500.9 PIK45509.1 - 0.0055 16.3 33.1 0.0055 16.3 33.1 3.5 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein Torus PF16131.5 PIK45509.1 - 0.039 14.7 0.2 0.039 14.7 0.2 3.4 3 2 2 5 5 5 0 Torus domain zf-CCCH_2 PF14608.6 PIK45509.1 - 0.19 12.3 2.8 0.3 11.6 2.8 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Ribosomal_L35Ae PF01247.18 PIK45511.1 - 5.5e-41 138.7 1.3 6.3e-41 138.5 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 PIK45511.1 - 0.011 15.9 0.1 2.8 8.2 0.1 2.2 2 0 0 2 2 2 0 RimM N-terminal domain RVT_1 PF00078.27 PIK45512.1 - 1.9e-07 30.8 0.0 2.3e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAS_3 PF08447.12 PIK45512.1 - 0.042 14.1 0.0 0.095 13.0 0.0 1.6 2 0 0 2 2 2 0 PAS fold UxuA PF03786.13 PIK45512.1 - 0.1 11.4 0.0 0.19 10.5 0.0 1.4 2 0 0 2 2 2 0 D-mannonate dehydratase (UxuA) PaRep2a PF07903.11 PIK45513.1 - 0.061 13.2 0.2 4.1 7.3 0.0 2.2 1 1 1 2 2 2 0 PaRep2a protein IQ PF00612.27 PIK45514.1 - 4e-05 23.0 0.5 0.00013 21.5 0.5 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif PhosphMutase PF10143.9 PIK45514.1 - 0.16 11.8 5.6 0.14 12.0 2.8 2.2 2 0 0 2 2 2 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Lectin_N PF03954.14 PIK45514.1 - 6.4 6.5 11.2 3.4 7.4 2.5 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain MFS_1_like PF12832.7 PIK45515.1 - 7.1e-71 239.1 11.9 8.5e-71 238.8 11.9 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK45515.1 - 7.8e-17 61.2 26.4 1.3e-16 60.5 26.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 PIK45515.1 - 1.3e-09 37.3 13.1 1.5e-05 24.0 5.4 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter Nuc_H_symport PF03825.16 PIK45515.1 - 2.2e-07 30.2 10.9 1.7e-06 27.3 5.9 2.1 2 0 0 2 2 2 2 Nucleoside H+ symporter MFS_3 PF05977.13 PIK45515.1 - 0.1 11.0 1.6 6 5.1 0.0 2.8 3 0 0 3 3 3 0 Transmembrane secretion effector EXS PF03124.14 PIK45515.1 - 0.18 11.1 9.1 0.061 12.6 1.5 2.2 1 1 1 2 2 2 0 EXS family DUF4131 PF13567.6 PIK45515.1 - 0.76 9.4 4.0 11 5.7 0.3 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) EF-hand_7 PF13499.6 PIK45516.1 - 1.3e-12 47.9 8.2 4.6e-07 30.2 0.2 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK45516.1 - 1.5e-12 46.1 14.2 5e-07 28.8 2.1 4.6 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 PIK45516.1 - 4.5e-12 44.9 11.5 8.9e-08 31.5 1.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 PIK45516.1 - 2.5e-07 30.4 7.6 0.0071 16.2 0.2 4.6 1 1 4 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK45516.1 - 6.2e-05 22.3 2.2 6.2e-05 22.3 2.2 3.1 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 PIK45516.1 - 8.8e-05 22.8 0.0 0.43 11.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain DUF2666 PF10869.8 PIK45516.1 - 0.00074 19.7 0.2 0.1 12.8 0.1 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2666) UPF0154 PF03672.13 PIK45516.1 - 0.0033 17.4 0.0 3.4 7.8 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) Syntaxin PF00804.25 PIK45516.1 - 0.0035 17.1 0.4 0.33 10.6 0.1 2.0 2 0 0 2 2 2 1 Syntaxin EF-hand_14 PF17959.1 PIK45516.1 - 0.03 14.7 0.2 7.7 6.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 PIK45516.1 - 0.049 13.9 0.2 0.11 12.8 0.2 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region HrpJ PF07201.11 PIK45516.1 - 0.079 13.3 0.7 0.24 11.7 0.2 2.0 2 1 1 3 3 3 0 HrpJ-like domain EF-hand_11 PF08976.11 PIK45516.1 - 0.11 13.3 0.4 0.5 11.3 0.1 2.0 1 1 1 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 PIK45517.1 - 8.3e-12 45.4 1.3 8.2e-08 32.6 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK45517.1 - 1.4e-11 43.3 3.4 7.3e-08 31.7 0.8 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK45517.1 - 1.9e-09 36.4 9.8 1.7e-07 30.3 1.3 4.1 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 PIK45517.1 - 3.9e-06 26.6 4.8 0.011 15.5 0.2 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK45517.1 - 2.2e-05 23.7 1.6 2.2e-05 23.7 1.6 2.9 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 PIK45517.1 - 0.00085 19.6 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain DUF2666 PF10869.8 PIK45517.1 - 0.0059 16.8 0.1 0.028 14.6 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2666) Syntaxin PF00804.25 PIK45517.1 - 0.029 14.0 0.1 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Syntaxin SPARC_Ca_bdg PF10591.9 PIK45517.1 - 0.031 14.6 0.3 0.058 13.7 0.3 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 PIK45517.1 - 0.13 12.4 0.8 1.8 8.7 0.0 2.4 2 1 0 2 2 2 0 Ca2+ insensitive EF hand Pkinase_Tyr PF07714.17 PIK45518.1 - 7.9e-63 212.1 0.0 1.1e-62 211.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45518.1 - 1.3e-38 132.9 0.0 1.8e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK45518.1 - 6.6e-14 51.8 0.0 1.2e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RIO1 PF01163.22 PIK45518.1 - 1.4e-05 24.7 0.1 2.4e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 PIK45518.1 - 0.0077 15.2 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK45518.1 - 0.015 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK45518.1 - 0.037 13.4 0.1 0.071 12.5 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_transpo PF04515.12 PIK45519.1 - 6.6e-74 249.0 47.4 1.4e-66 224.9 23.7 4.4 3 1 1 4 4 4 4 Plasma-membrane choline transporter Fibrinogen_C PF00147.18 PIK45520.1 - 4.8e-47 160.6 1.4 1.9e-44 152.1 1.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK45520.1 - 0.00012 22.2 7.4 0.00012 22.2 7.4 3.4 3 1 0 3 3 3 1 EGF domain TIL PF01826.17 PIK45520.1 - 0.00015 21.9 12.8 0.00015 21.9 12.8 2.7 1 1 1 2 2 2 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK45520.1 - 0.0044 16.9 2.0 0.0044 16.9 2.0 2.5 2 0 0 2 2 2 1 TILa domain COLFI PF01410.18 PIK45520.1 - 0.025 13.9 0.6 0.025 13.9 0.6 1.9 1 1 1 2 2 2 0 Fibrillar collagen C-terminal domain TP6A_N PF04406.14 PIK45521.1 - 4.7e-12 45.7 0.0 9.1e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF5351 PF17302.2 PIK45521.1 - 0.21 11.8 12.1 8.4 6.7 0.3 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5351) Actin PF00022.19 PIK45522.1 - 9e-69 232.0 0.0 1e-68 231.8 0.0 1.0 1 0 0 1 1 1 1 Actin FCH PF00611.23 PIK45523.1 - 3.9e-15 55.9 2.0 9.2e-15 54.7 1.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 PIK45523.1 - 2.1e-13 49.9 0.2 3.7e-13 49.1 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK45523.1 - 8.2e-13 47.7 0.2 1.7e-12 46.8 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK45523.1 - 3.4e-11 42.6 0.0 1.1e-10 41.0 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain DNMT1-RFD PF12047.8 PIK45523.1 - 0.033 14.2 1.2 0.072 13.1 0.1 2.2 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain DUF2993 PF11209.8 PIK45525.1 - 0.0067 16.7 0.2 1.9 8.7 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF2993) DAD PF02109.16 PIK45526.1 - 2.9e-48 162.7 3.5 3.2e-48 162.6 3.5 1.0 1 0 0 1 1 1 1 DAD family Exostosin PF03016.15 PIK45527.1 - 2.2e-12 46.8 0.0 2.8e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DUF1640 PF07798.11 PIK45528.1 - 8e-46 156.3 12.3 9.7e-46 156.0 12.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DUF5043 PF16446.5 PIK45528.1 - 0.061 13.3 0.6 0.27 11.2 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5043) Spore_GerAC PF05504.11 PIK45528.1 - 0.13 12.4 2.4 0.21 11.8 2.4 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal G-gamma PF00631.22 PIK45528.1 - 0.22 11.5 1.2 0.6 10.1 0.3 2.2 1 1 0 2 2 2 0 GGL domain CRR7 PF12095.8 PIK45528.1 - 0.92 10.0 4.3 1 9.9 2.4 2.0 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 UQ_con PF00179.26 PIK45529.1 - 3e-46 156.6 0.0 3.6e-46 156.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK45529.1 - 7.7e-05 23.0 0.0 0.00014 22.1 0.0 1.6 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 PIK45529.1 - 0.00051 19.9 0.0 0.00077 19.3 0.0 1.4 1 0 0 1 1 1 1 UEV domain CLTH PF10607.9 PIK45530.1 - 9.5e-43 145.6 0.1 1.4e-42 145.1 0.1 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 PIK45530.1 - 2.5e-21 76.0 1.7 5.3e-21 75.0 0.1 2.1 2 0 0 2 2 2 1 SPRY domain LisH PF08513.11 PIK45530.1 - 7.9e-06 25.6 0.0 2.1e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 LisH MCC-bdg_PDZ PF10506.9 PIK45530.1 - 0.0032 17.5 0.1 0.008 16.2 0.1 1.6 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome ROK PF00480.20 PIK45530.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 ROK family TSNAXIP1_N PF15739.5 PIK45531.1 - 8.9e-32 109.8 8.8 1.8e-31 108.8 8.8 1.5 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus TPR_MLP1_2 PF07926.12 PIK45531.1 - 0.00074 19.6 9.0 0.0015 18.5 8.9 1.6 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 PIK45531.1 - 0.043 13.2 5.7 0.032 13.6 1.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DivIC PF04977.15 PIK45531.1 - 1.6 8.6 7.8 0.38 10.5 4.2 1.8 2 0 0 2 2 2 0 Septum formation initiator JAKMIP_CC3 PF16034.5 PIK45531.1 - 7 6.5 18.2 1.2e+02 2.6 18.2 2.2 1 1 0 1 1 1 0 JAKMIP CC3 domain Kinesin PF00225.23 PIK45533.1 - 2.1e-76 257.0 4.1 1.4e-59 201.7 0.5 2.6 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 PIK45533.1 - 7.1e-10 39.0 0.0 2.8e-09 37.1 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 PIK45533.1 - 4.2e-07 30.3 17.2 7.8e-07 29.4 2.2 4.3 3 2 2 5 5 5 2 Kinesin-associated FHA PF00498.26 PIK45533.1 - 2.3e-06 27.9 0.0 1.5e-05 25.2 0.0 2.5 3 0 0 3 3 3 1 FHA domain KIF1B PF12423.8 PIK45533.1 - 0.00018 21.8 2.7 0.00041 20.7 0.1 3.0 3 0 0 3 3 3 1 Kinesin protein 1B Yop-YscD_cpl PF16697.5 PIK45533.1 - 0.06 13.7 0.0 0.2 12.0 0.0 2.0 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain SKA2 PF16740.5 PIK45533.1 - 0.22 11.3 9.7 0.14 12.0 3.5 2.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 SPK PF04435.18 PIK45533.1 - 0.82 10.1 4.1 0.8 10.1 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF545) E2F_CC-MB PF16421.5 PIK45534.1 - 2.1e-30 104.9 0.2 3.6e-30 104.2 0.2 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 PIK45534.1 - 6.4e-25 87.0 1.9 1.9e-24 85.5 0.1 2.2 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain CLZ PF16526.5 PIK45534.1 - 0.038 14.3 0.7 5.2 7.5 0.0 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TrmB PF01978.19 PIK45534.1 - 0.042 13.7 0.4 2.1 8.3 0.0 2.7 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB VCX_VCY PF15231.6 PIK45534.1 - 0.044 14.5 1.2 0.11 13.2 1.2 1.6 1 0 0 1 1 1 0 Variable charge X/Y family B-block_TFIIIC PF04182.12 PIK45534.1 - 0.17 12.1 0.0 0.45 10.7 0.0 1.7 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC ZapB PF06005.12 PIK45534.1 - 1.1 9.7 6.0 2.4 8.6 6.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 PIK45535.1 - 4.3e-15 55.5 9.0 6.4e-15 55.0 9.0 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK45535.1 - 8.7e-05 22.5 7.5 0.00016 21.7 7.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor ZapB PF06005.12 PIK45535.1 - 0.014 15.9 0.8 0.021 15.3 0.0 1.7 2 0 0 2 2 2 0 Cell division protein ZapB tRNA-synt_1b PF00579.25 PIK45535.1 - 0.32 10.3 2.1 0.47 9.7 2.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) DivIC PF04977.15 PIK45535.1 - 1.4 8.7 4.1 0.51 10.2 1.1 1.9 2 1 0 2 2 2 0 Septum formation initiator RVT_1 PF00078.27 PIK45536.1 - 2.6e-27 95.8 0.8 2.9e-27 95.6 0.8 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK45537.1 - 5.7e-11 42.3 0.2 1.4e-08 34.5 0.1 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Spore_GerAC PF05504.11 PIK45538.1 - 0.01 16.0 2.4 0.9 9.7 2.4 2.2 1 1 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal LBP_BPI_CETP_C PF02886.17 PIK45539.1 - 1e-32 113.5 0.0 1.5e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK45539.1 - 9.7e-07 28.5 0.0 3.8e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain 7tm_1 PF00001.21 PIK45540.1 - 1.1e-26 93.8 7.6 1.4e-26 93.4 7.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK45540.1 - 1.2e-07 31.4 2.9 1.6e-07 31.0 2.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK45540.1 - 3.6e-06 26.9 5.0 4.4e-06 26.6 4.6 1.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK45540.1 - 2.2e-05 24.2 4.9 3.6e-05 23.5 4.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK45540.1 - 0.0072 15.7 11.3 0.004 16.6 8.4 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx TM2 PF05154.16 PIK45541.1 - 1.1e-08 35.3 0.8 2.1e-08 34.4 0.8 1.5 1 0 0 1 1 1 1 TM2 domain DEAD PF00270.29 PIK45542.1 - 4e-47 160.2 0.0 1.2e-46 158.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK45542.1 - 5.6e-24 84.6 0.4 4.1e-23 81.8 0.0 2.5 3 1 1 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK45542.1 - 7.6e-07 29.3 0.0 1.9e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Phage_integrase PF00589.22 PIK45542.1 - 0.01 15.7 0.3 0.02 14.7 0.0 1.6 2 0 0 2 2 2 0 Phage integrase family AAA_22 PF13401.6 PIK45542.1 - 0.22 11.8 0.9 2.7 8.3 0.9 2.4 1 1 0 1 1 1 0 AAA domain PGBA_C PF15437.6 PIK45542.1 - 0.34 11.3 9.7 0.63 10.4 9.7 1.3 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal ubiquitin PF00240.23 PIK45543.1 - 3e-54 180.7 18.5 1.2e-11 44.2 0.4 5.1 4 1 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 PIK45543.1 - 1.8e-23 82.2 11.2 7.3e-05 22.5 0.2 5.1 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK45543.1 - 4.1e-12 46.4 7.3 0.061 13.8 0.1 4.7 4 1 0 4 4 4 4 Ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK45543.1 - 0.0036 17.3 5.7 26 4.9 0.1 4.7 5 1 0 5 5 5 0 Ubiquitin-like domain Bromo_TP_like PF17027.5 PIK45543.1 - 0.01 16.0 3.3 16 5.7 0.2 3.5 4 0 0 4 4 4 0 Histone-fold protein USP7_C2 PF14533.6 PIK45543.1 - 0.012 15.3 1.1 26 4.4 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-specific protease C-terminal DUF5119 PF17145.4 PIK45543.1 - 0.019 14.9 1.3 16 5.4 0.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF5119) APG12 PF04110.13 PIK45543.1 - 0.041 14.3 0.5 63 4.1 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-like autophagy protein Apg12 Spore-coat_CotD PF11122.8 PIK45543.1 - 0.044 14.6 3.3 85 4.1 0.0 4.1 3 2 2 5 5 5 0 Inner spore coat protein D YcgR_2 PF12945.7 PIK45543.1 - 0.058 13.5 3.1 51 4.1 0.1 3.6 3 0 0 3 3 3 0 Flagellar protein YcgR GDYXXLXY PF14345.6 PIK45543.1 - 0.092 12.5 0.1 78 3.1 0.0 3.3 3 0 0 3 3 3 0 GDYXXLXY protein UDP-g_GGTase PF06427.11 PIK45543.1 - 0.094 12.8 0.3 5.6 7.1 0.0 2.9 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase TBK1_ULD PF18396.1 PIK45543.1 - 0.19 11.7 1.1 2.2 8.3 0.0 3.2 3 2 1 4 4 4 0 TANK binding kinase 1 ubiquitin-like domain ubiquitin PF00240.23 PIK45544.1 - 1.8e-81 267.9 12.2 5.1e-34 115.9 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 PIK45544.1 - 9.6e-41 137.5 9.9 1.5e-16 60.0 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK45544.1 - 2.2e-15 56.9 4.6 5.2e-05 23.6 0.1 4.1 3 2 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK45544.1 - 3.3e-08 33.4 1.3 0.0088 16.0 0.0 2.7 3 0 0 3 3 3 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK45544.1 - 4.8e-08 33.1 0.8 0.037 14.1 0.0 3.6 3 2 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 PIK45544.1 - 6.6e-08 32.8 0.7 0.015 15.6 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 PIK45544.1 - 6.1e-06 26.7 0.2 0.11 13.1 0.1 2.3 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK45544.1 - 1.2e-05 25.3 9.9 13 5.9 0.1 5.0 5 0 0 5 5 5 0 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 PIK45544.1 - 1.5e-05 24.9 0.3 0.65 9.8 0.0 3.0 1 1 2 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain UDP-g_GGTase PF06427.11 PIK45544.1 - 0.0011 19.1 1.3 2.9 8.1 0.0 2.9 3 0 0 3 3 3 2 UDP-glucose:Glycoprotein Glucosyltransferase RBD PF02196.15 PIK45544.1 - 0.0026 17.8 0.0 15 5.7 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain Methyltrans_RNA PF04452.14 PIK45544.1 - 0.0029 17.0 0.1 1.8 7.8 0.0 2.2 2 0 0 2 2 2 2 RNA methyltransferase DUF3861 PF12977.7 PIK45544.1 - 0.0061 16.7 0.0 20 5.5 0.0 3.1 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) UN_NPL4 PF11543.8 PIK45544.1 - 0.0094 16.4 1.1 23 5.5 0.0 3.3 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 YcgR_2 PF12945.7 PIK45544.1 - 0.012 15.8 2.5 30 4.8 0.0 3.3 3 0 0 3 3 3 0 Flagellar protein YcgR DUF2870 PF11069.8 PIK45544.1 - 0.03 14.7 0.0 17 5.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) GDYXXLXY PF14345.6 PIK45544.1 - 0.034 13.9 0.1 63 3.3 0.0 3.3 3 0 0 3 3 3 0 GDYXXLXY protein Big_7 PF17957.1 PIK45544.1 - 0.039 14.7 0.2 82 4.1 0.1 3.1 3 0 0 3 3 3 0 Bacterial Ig domain TraK PF06586.11 PIK45544.1 - 0.047 13.4 0.2 50 3.5 0.0 3.0 3 0 0 3 3 3 0 TraK protein DUF969 PF06149.12 PIK45544.1 - 0.066 12.6 0.0 12 5.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF969) YfmQ PF10787.9 PIK45544.1 - 0.1 12.4 0.1 17 5.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein from bacillus cereus group DUF5119 PF17145.4 PIK45544.1 - 0.17 11.8 0.5 4.8 7.1 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5119) ProRS-C_2 PF09181.10 PIK45544.1 - 0.24 11.6 1.3 1.2e+02 3.0 0.0 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal FlgD_ig PF13860.6 PIK45544.1 - 0.83 9.6 3.0 95 3.0 0.1 3.2 3 0 0 3 3 3 0 FlgD Ig-like domain PI3K_p85B PF02192.16 PIK45544.1 - 1.2 9.0 3.9 93 2.9 0.1 3.2 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Myosin_N PF02736.19 PIK45544.1 - 1.2 9.0 5.8 64 3.5 0.0 4.2 5 0 0 5 5 3 0 Myosin N-terminal SH3-like domain DUF1059 PF06348.11 PIK45544.1 - 1.6 9.0 3.1 1.5e+02 2.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) MnmE_helical PF12631.7 PIK45545.1 - 1.2e-49 169.3 1.0 1.9e-49 168.7 1.0 1.3 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 PIK45545.1 - 7.3e-36 123.0 0.0 2e-35 121.6 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 PIK45545.1 - 1.2e-21 76.9 0.6 3.9e-21 75.3 0.6 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK45545.1 - 5.9e-11 42.1 0.4 2.4e-10 40.2 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK45545.1 - 4.1e-07 30.1 0.3 0.0035 17.3 0.0 2.6 2 1 0 2 2 2 2 RsgA GTPase cobW PF02492.19 PIK45545.1 - 0.00017 21.2 0.2 0.0035 17.0 0.1 2.4 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 PIK45545.1 - 0.00035 20.7 0.0 0.00074 19.6 0.0 1.7 1 1 0 1 1 1 1 Dynamin family ABC_tran PF00005.27 PIK45545.1 - 0.0021 18.6 0.8 0.007 16.9 0.8 2.1 1 1 0 1 1 1 1 ABC transporter GTP_EFTU PF00009.27 PIK45545.1 - 0.0032 17.1 1.0 2.5 7.6 0.6 3.0 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain MCM PF00493.23 PIK45545.1 - 0.0037 16.4 0.0 0.0076 15.4 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain Adeno_PIX PF03955.14 PIK45545.1 - 0.034 14.3 0.3 0.058 13.6 0.3 1.3 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Mer2 PF09074.10 PIK45545.1 - 0.054 13.3 1.0 8.1 6.2 0.3 2.2 2 0 0 2 2 2 0 Mer2 Gtr1_RagA PF04670.12 PIK45545.1 - 0.064 12.6 0.1 0.2 10.9 0.1 1.9 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 PIK45545.1 - 0.11 12.2 0.0 0.83 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain UPF0242 PF06785.11 PIK45546.1 - 0.0027 17.8 12.7 0.0042 17.2 11.6 1.8 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 PIK45546.1 - 0.014 15.4 22.2 12 6.0 21.5 2.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1043 PF06295.12 PIK45546.1 - 0.045 13.7 7.3 0.28 11.2 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Tnp_22_trimer PF17489.2 PIK45546.1 - 0.1 12.5 5.5 0.059 13.4 2.0 2.4 2 0 0 2 2 2 0 L1 transposable element trimerization domain AAA_13 PF13166.6 PIK45546.1 - 0.15 10.7 10.3 0.22 10.1 10.3 1.2 1 0 0 1 1 1 0 AAA domain ADIP PF11559.8 PIK45546.1 - 0.16 12.1 18.0 0.069 13.2 5.2 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 PIK45546.1 - 0.5 10.6 23.5 3.6 7.8 10.4 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 PIK45546.1 - 0.5 10.4 8.5 1.1 9.3 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PspB PF06667.12 PIK45546.1 - 0.63 10.1 3.5 0.7 10.0 0.1 2.3 2 0 0 2 2 2 0 Phage shock protein B DUF4094 PF13334.6 PIK45546.1 - 1.5 9.3 4.3 18 5.9 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) NBP1 PF08537.10 PIK45546.1 - 1.9 7.9 13.0 3.4 7.0 13.0 1.4 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 GAS PF13851.6 PIK45546.1 - 2.1 7.6 19.5 72 2.6 19.6 2.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 PIK45546.1 - 3.8 7.1 21.3 20 4.8 21.3 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.16 PIK45546.1 - 4.2 7.9 10.3 1.1 9.8 5.3 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 PIK45546.1 - 4.6 7.4 20.9 12 6.1 5.8 2.6 1 1 1 2 2 2 0 Tropomyosin like APG6_N PF17675.1 PIK45546.1 - 4.9 7.7 25.1 0.11 13.0 6.2 2.6 2 1 1 3 3 3 0 Apg6 coiled-coil region Ly49 PF08391.10 PIK45546.1 - 5.5 7.4 8.8 1.2 9.6 2.6 2.5 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region DivIC PF04977.15 PIK45546.1 - 5.7 6.8 13.7 0.15 11.8 0.5 3.3 2 1 1 3 3 3 0 Septum formation initiator Cep57_CLD_2 PF14197.6 PIK45546.1 - 9.2 6.4 17.2 1.8 8.7 4.8 3.3 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 HSP20 PF00011.21 PIK45547.1 - 4.8e-06 26.6 0.0 1.3e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Macoilin PF09726.9 PIK45547.1 - 1.4 7.4 14.3 1.7 7.1 14.3 1.1 1 0 0 1 1 1 0 Macoilin family YL1 PF05764.13 PIK45548.1 - 0.0033 17.6 3.8 0.0043 17.2 3.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein ORC_WH_C PF18137.1 PIK45548.1 - 0.0065 16.6 2.2 0.0065 16.5 1.1 1.4 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal FAM91_C PF14648.6 PIK45548.1 - 0.079 11.8 0.2 0.092 11.6 0.2 1.1 1 0 0 1 1 1 0 FAM91 C-terminus SET PF00856.28 PIK45549.1 - 6.1e-09 36.5 0.2 4.4e-08 33.7 0.0 2.6 2 1 0 2 2 2 1 SET domain PPO1_DWL PF12142.8 PIK45549.1 - 0.038 13.8 0.0 0.086 12.6 0.0 1.6 1 0 0 1 1 1 0 Polyphenol oxidase middle domain DUF4187 PF13821.6 PIK45549.1 - 0.059 13.2 0.4 0.18 11.6 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) BUD22 PF09073.10 PIK45549.1 - 0.13 11.6 13.3 0.22 10.8 13.3 1.4 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 PIK45549.1 - 1.9 7.9 15.0 3.3 7.0 15.0 1.4 1 0 0 1 1 1 0 SDA1 NACHT PF05729.12 PIK45550.1 - 2.4e-14 53.6 1.0 2.6e-13 50.2 0.0 2.4 2 0 0 2 2 2 1 NACHT domain Ig_3 PF13927.6 PIK45550.1 - 1.4e-07 32.0 7.4 0.018 15.7 0.1 4.8 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK45550.1 - 1.3e-06 28.5 0.3 0.00016 21.8 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK45550.1 - 1.9e-05 24.6 0.1 0.00011 22.1 0.4 2.2 2 0 0 2 2 2 1 TMEM154 protein family I-set PF07679.16 PIK45550.1 - 3.8e-05 23.7 1.3 0.61 10.2 0.0 3.7 4 0 0 4 4 4 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK45550.1 - 5.1e-05 23.3 1.0 0.33 11.0 0.1 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK45550.1 - 0.00014 22.1 1.8 0.4 11.0 0.0 4.6 4 0 0 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK45550.1 - 0.00071 19.7 1.4 0.47 10.7 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin domain NB-ARC PF00931.22 PIK45550.1 - 0.0013 18.0 0.0 0.0029 16.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Cadherin_C_2 PF16492.5 PIK45550.1 - 0.0024 18.6 0.1 0.0082 16.9 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal AAA_25 PF13481.6 PIK45550.1 - 0.067 12.8 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Orf78 PF06024.12 PIK45550.1 - 0.38 11.1 4.3 0.79 10.1 0.1 3.0 3 0 0 3 3 3 0 Orf78 (ac78) NACHT PF05729.12 PIK45551.1 - 7.2e-15 55.3 0.0 1.6e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK45551.1 - 8.4e-08 32.2 4.1 0.00086 19.3 0.5 2.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK45551.1 - 3.9e-07 30.2 0.4 0.031 14.4 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK45551.1 - 3e-06 27.8 8.0 0.88 10.2 0.0 5.4 5 1 0 5 5 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK45551.1 - 9.9e-05 22.6 2.0 1.9 8.9 0.1 4.7 4 0 0 4 4 4 1 Immunoglobulin domain AAA_22 PF13401.6 PIK45551.1 - 0.026 14.8 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK45551.1 - 0.034 13.7 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain EphA2_TM PF14575.6 PIK45551.1 - 0.079 13.9 0.2 0.41 11.6 0.1 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CobA_CobO_BtuR PF02572.15 PIK45551.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP I-set PF07679.16 PIK45551.1 - 0.18 11.9 3.4 3.7 7.7 0.0 4.1 4 1 1 5 5 5 0 Immunoglobulin I-set domain ig PF00047.25 PIK45551.1 - 4.9 7.4 10.7 23 5.2 0.0 4.7 5 1 1 6 6 5 0 Immunoglobulin domain DUF4083 PF13314.6 PIK45551.1 - 7.8 6.5 9.3 0.52 10.3 1.9 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) NACHT PF05729.12 PIK45552.1 - 6.2e-07 29.5 0.1 1.3e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK45552.1 - 0.04 13.5 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4248 PF14053.6 PIK45552.1 - 0.053 13.6 0.0 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) NB-ARC PF00931.22 PIK45552.1 - 0.094 11.9 0.3 0.23 10.6 0.3 1.6 1 0 0 1 1 1 0 NB-ARC domain Pkinase_Tyr PF07714.17 PIK45553.1 - 4.5e-30 104.8 0.0 7.1e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45553.1 - 1.6e-20 73.6 0.0 2.4e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK45553.1 - 0.079 13.0 0.0 0.33 11.0 0.0 2.1 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK45554.1 - 5.9e-14 52.3 0.0 2.1e-13 50.5 0.0 2.0 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK45554.1 - 6.4e-05 23.5 0.8 9.2 6.9 0.0 3.6 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK45554.1 - 0.00016 22.0 0.3 0.057 13.8 0.1 2.9 2 1 0 2 2 2 1 Immunoglobulin domain MAP17 PF15807.5 PIK45554.1 - 0.00034 20.8 0.0 0.00078 19.7 0.0 1.5 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Marek_A PF02124.15 PIK45554.1 - 0.0015 18.4 1.8 0.0025 17.7 0.4 2.0 2 1 1 3 3 3 1 Marek's disease glycoprotein A V-set PF07686.17 PIK45554.1 - 0.0031 17.7 0.2 0.032 14.4 0.0 2.7 3 1 0 3 3 3 1 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK45554.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2207 PF09972.9 PIK45554.1 - 0.076 11.8 0.1 0.18 10.6 0.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) NACHT PF05729.12 PIK45555.1 - 6.4e-10 39.2 0.0 2.1e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK45555.1 - 0.00024 20.8 0.0 0.01 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain GDE_N PF12439.8 PIK45555.1 - 0.00073 19.0 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 Glycogen debranching enzyme N terminal V-set PF07686.17 PIK45555.1 - 0.0087 16.2 0.3 1.5 9.0 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain AAA_22 PF13401.6 PIK45555.1 - 0.009 16.3 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ig_2 PF13895.6 PIK45555.1 - 0.027 14.8 1.4 8.1 6.9 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin domain Bacteriocin_IId PF09221.10 PIK45555.1 - 0.04 14.1 1.7 1.5 9.0 1.0 2.6 2 0 0 2 2 2 0 Bacteriocin class IId cyclical uberolysin-like GNVR PF13807.6 PIK45555.1 - 0.39 10.7 1.3 1.2 9.1 0.6 2.2 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Pkinase_Tyr PF07714.17 PIK45556.1 - 1.2e-29 103.4 0.1 1.9e-29 102.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45556.1 - 2.6e-23 82.8 0.1 4.2e-23 82.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK45556.1 - 4.1e-13 49.2 6.2 1.5e-06 28.2 0.1 3.3 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK45556.1 - 0.00055 20.5 3.9 0.037 14.6 0.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain YccF PF03733.13 PIK45556.1 - 0.24 12.2 1.9 0.83 10.4 1.9 1.9 1 0 0 1 1 1 0 Inner membrane component domain DUF4307 PF14155.6 PIK45556.1 - 4.9 7.0 9.0 1.1 9.1 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4307) NACHT PF05729.12 PIK45557.1 - 2.7e-06 27.4 0.0 9.2e-06 25.7 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK45557.1 - 0.018 14.7 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Patatin PF01734.22 PIK45558.1 - 2e-28 100.0 0.0 3.7e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase fn3 PF00041.21 PIK45559.1 - 6.2e-33 113.0 6.4 2.3e-12 47.1 0.1 4.5 4 0 0 4 4 4 4 Fibronectin type III domain I-set PF07679.16 PIK45559.1 - 1.6e-24 85.8 0.5 1.8e-07 31.1 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK45559.1 - 1.8e-21 76.5 4.3 6.1e-07 29.9 0.0 5.0 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 PIK45559.1 - 7.9e-18 64.6 1.2 1.5e-06 28.5 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK45559.1 - 1.6e-17 63.5 0.0 1.1e-06 28.8 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK45559.1 - 1.2e-10 41.5 2.9 0.083 13.1 0.0 5.7 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK45559.1 - 2.1e-07 30.4 0.0 0.077 12.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Izumo-Ig PF16706.5 PIK45559.1 - 8e-05 22.6 0.3 0.71 10.0 0.0 3.7 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Tissue_fac PF01108.17 PIK45559.1 - 0.00027 20.8 0.4 3 7.8 0.1 3.7 3 0 0 3 3 3 1 Tissue factor Ig_5 PF16681.5 PIK45559.1 - 0.0038 17.6 0.4 0.47 10.9 0.0 3.0 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK45559.1 - 0.18 12.1 0.2 4.6 7.6 0.0 2.8 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 PIK45559.1 - 0.22 11.5 0.6 5.8 6.9 0.0 3.0 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain Reprolysin PF01421.19 PIK45560.1 - 2.1e-38 132.2 0.0 4.3e-38 131.2 0.0 1.5 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Disintegrin PF00200.23 PIK45560.1 - 0.00018 22.2 8.8 0.00018 22.2 8.8 1.7 2 0 0 2 2 2 1 Disintegrin Reprolysin_5 PF13688.6 PIK45560.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Ig_3 PF13927.6 PIK45560.1 - 0.081 13.5 0.2 0.17 12.5 0.2 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Hap4_Hap_bind PF10297.9 PIK45561.1 - 0.63 10.2 8.8 16 5.8 0.0 4.8 5 2 0 4 4 4 0 Minimal binding motif of Hap4 for binding to Hap2/3/5 Mating_N PF12731.7 PIK45562.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 rve PF00665.26 PIK45563.1 - 8e-20 71.2 0.0 1.1e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK45563.1 - 1e-16 60.8 0.1 1.7e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK45563.1 - 0.0011 19.2 0.0 0.0022 18.2 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK45563.1 - 0.0027 17.4 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK45564.1 - 1.6e-21 76.8 0.0 2e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK45565.1 - 3.3e-15 56.3 0.0 6.6e-15 55.3 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK45565.1 - 0.00047 19.9 0.6 0.029 14.2 0.0 2.7 2 1 1 3 3 3 1 Integrase core domain PIN_5 PF08745.11 PIK45565.1 - 0.17 11.3 0.1 0.43 10.0 0.0 1.7 2 0 0 2 2 2 0 PINc domain ribonuclease RVT_1 PF00078.27 PIK45566.1 - 1.1e-10 41.5 0.1 1.8e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Guanylate_cyc PF00211.20 PIK45567.1 - 1.9e-68 229.7 0.1 2.8e-68 229.2 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK45567.1 - 5.1e-44 150.3 13.2 2.4e-43 148.1 9.1 2.6 2 1 0 2 2 2 1 Heme NO binding associated AMP-binding PF00501.28 PIK45567.1 - 0.051 12.2 0.0 0.089 11.4 0.0 1.3 1 0 0 1 1 1 0 AMP-binding enzyme MctB PF11382.8 PIK45567.1 - 0.37 10.5 3.0 0.2 11.3 1.1 1.5 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB Smg4_UPF3 PF03467.15 PIK45568.1 - 6.1e-51 172.9 0.2 6.1e-51 172.9 0.2 3.3 2 1 1 3 3 3 1 Smg-4/UPF3 family SID-1_RNA_chan PF13965.6 PIK45568.1 - 0.2 10.0 3.9 0.35 9.2 3.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FYVE PF01363.21 PIK45569.1 - 6.3e-16 58.3 25.6 1.1e-09 38.2 15.1 2.6 2 0 0 2 2 2 2 FYVE zinc finger MADF_DNA_bdg PF10545.9 PIK45569.1 - 0.048 14.0 19.6 2.1 8.7 0.6 5.5 5 0 0 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Scramblase PF03803.15 PIK45570.1 - 7.8e-45 152.9 0.1 1.7e-28 99.5 0.0 2.4 3 0 0 3 3 3 2 Scramblase GRP PF07172.11 PIK45572.1 - 0.33 11.7 40.4 1 10.1 33.1 2.2 2 0 0 2 2 2 0 Glycine rich protein family Prp18 PF02840.15 PIK45573.1 - 1.7e-45 154.6 0.0 4e-45 153.4 0.0 1.5 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.11 PIK45573.1 - 6.3e-11 41.6 2.8 1.3e-10 40.6 2.8 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DUF5371 PF17341.2 PIK45573.1 - 0.073 13.3 0.0 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5371) Nop16 PF09420.10 PIK45573.1 - 0.093 12.7 2.8 0.19 11.7 0.3 2.2 1 1 1 2 2 2 0 Ribosome biogenesis protein Nop16 DUF4252 PF14060.6 PIK45573.1 - 0.16 11.9 1.1 0.26 11.2 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4252) zf-RING_6 PF14835.6 PIK45574.1 - 8.5e-10 38.4 5.8 1.9e-07 30.8 5.4 2.8 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 PIK45574.1 - 4.2e-08 32.9 12.6 4.2e-08 32.9 12.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 PIK45574.1 - 2e-07 30.6 0.4 4.4e-07 29.5 0.4 1.6 1 0 0 1 1 1 1 SAP domain zf-C3HC4_3 PF13920.6 PIK45574.1 - 5.9e-06 26.1 15.5 5.8e-05 22.9 11.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK45574.1 - 8.2e-06 25.6 15.0 8.2e-06 25.6 15.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK45574.1 - 1.3e-05 25.5 12.4 1.3e-05 25.5 12.4 2.8 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK45574.1 - 2.8e-05 24.0 17.6 5e-05 23.2 13.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK45574.1 - 0.00029 20.8 9.6 0.00029 20.8 9.6 2.3 2 0 0 2 2 2 1 RING-type zinc-finger RNF220 PF15926.5 PIK45574.1 - 0.00081 19.1 0.4 0.00081 19.1 0.4 2.5 3 0 0 3 3 3 1 E3 ubiquitin-protein ligase RNF220 zf-RING_10 PF16685.5 PIK45574.1 - 0.0013 18.8 10.5 0.0018 18.3 9.3 1.9 1 1 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 PIK45574.1 - 0.0078 16.5 9.9 0.0078 16.5 9.9 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain DNA_ligase_ZBD PF03119.16 PIK45574.1 - 0.2 11.7 4.2 4.1 7.5 1.0 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-ANAPC11 PF12861.7 PIK45574.1 - 0.35 11.0 5.6 0.3 11.2 2.3 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 PIK45574.1 - 0.36 10.7 13.8 3.7 7.5 9.8 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF3123 PF11321.8 PIK45574.1 - 0.77 10.5 2.9 27 5.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) zf-C3HC4_4 PF15227.6 PIK45574.1 - 1.7 8.9 19.1 0.47 10.6 14.7 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-WRNIP1_ubi PF18279.1 PIK45574.1 - 1.8 9.4 5.0 3.4 8.5 0.6 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-Mss51 PF13824.6 PIK45574.1 - 3.5 7.8 6.4 1.4 9.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DZR PF12773.7 PIK45574.1 - 8.6 6.5 12.3 25 5.0 0.1 2.6 2 0 0 2 2 2 0 Double zinc ribbon C2-set_2 PF08205.12 PIK45575.1 - 9.4e-05 22.4 3.3 0.31 11.1 1.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK45575.1 - 0.00054 20.5 6.3 8.8 7.0 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin domain RHH_4 PF13467.6 PIK45575.1 - 0.0094 15.8 0.1 0.7 9.8 0.0 4.4 5 0 0 5 5 5 1 Ribbon-helix-helix domain DnaB_2 PF07261.11 PIK45575.1 - 0.015 15.1 7.4 0.29 10.9 0.0 4.3 4 0 0 4 4 4 0 Replication initiation and membrane attachment FeoB_associated PF12669.7 PIK45575.1 - 0.085 13.3 3.2 0.25 11.8 3.2 1.8 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Syndecan PF01034.20 PIK45575.1 - 0.19 11.6 2.0 0.48 10.4 2.0 1.6 1 0 0 1 1 1 0 Syndecan domain Zip PF02535.22 PIK45575.1 - 0.28 10.4 2.6 0.48 9.6 2.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RST PF12174.8 PIK45575.1 - 0.74 9.8 26.7 2 8.4 0.0 9.0 8 2 0 9 9 9 0 RCD1-SRO-TAF4 (RST) plant domain C2-set_2 PF08205.12 PIK45576.1 - 0.02 14.9 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Abhydro_lipase PF04083.16 PIK45576.1 - 0.06 12.9 0.0 2.2 7.9 0.0 2.3 1 1 1 2 2 2 0 Partial alpha/beta-hydrolase lipase region Pkinase_Tyr PF07714.17 PIK45577.1 - 1.4e-37 129.4 0.0 1.7e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45577.1 - 4.1e-16 59.1 0.0 5.9e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CH_2 PF06294.11 PIK45577.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein RVT_1 PF00078.27 PIK45578.1 - 2.4e-12 46.9 0.2 3.6e-12 46.3 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CPSase_L_D3 PF02787.19 PIK45578.1 - 0.031 14.6 0.2 0.068 13.5 0.1 1.6 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Tcell_CD4_C PF12104.8 PIK45578.1 - 0.21 11.5 0.5 0.42 10.6 0.5 1.5 1 0 0 1 1 1 0 T cell CD4 receptor C terminal region ABC_tran PF00005.27 PIK45579.1 - 9.2e-29 100.7 0.0 1.6e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK45579.1 - 2.6e-06 27.1 0.1 0.00039 19.9 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 PIK45579.1 - 0.01 15.5 0.4 0.014 15.0 0.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_24 PF13479.6 PIK45579.1 - 0.02 14.6 0.5 0.044 13.5 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 PIK45579.1 - 0.028 14.2 1.0 1.5 8.6 0.2 2.6 1 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 PIK45579.1 - 0.073 13.1 0.8 0.23 11.5 0.2 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_29 PF13555.6 PIK45579.1 - 0.095 12.5 0.1 0.29 10.9 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane PF00664.23 PIK45580.1 - 1.4e-29 103.6 19.0 8.8e-26 91.2 10.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 PIK45580.1 - 4.5e-18 66.1 1.3 1.9e-17 64.1 0.0 2.4 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 PIK45580.1 - 2e-06 27.4 1.0 0.00093 18.7 1.0 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 PIK45580.1 - 0.002 18.2 4.6 0.013 15.6 4.8 2.3 1 1 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 PIK45580.1 - 0.0091 15.9 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 PIK45580.1 - 0.03 13.9 0.0 0.067 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 PIK45580.1 - 0.09 11.4 0.0 0.09 11.4 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_21 PF13304.6 PIK45580.1 - 0.55 10.0 2.5 5.5 6.7 0.1 2.5 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system TraD_N PF12615.8 PIK45580.1 - 6 7.7 8.2 0.55 11.0 1.5 2.5 2 1 0 2 2 2 0 F sex factor protein N terminal DUF2157 PF09925.9 PIK45581.1 - 0.79 9.5 7.7 0.11 12.3 2.4 2.3 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) DUF1229 PF06797.11 PIK45581.1 - 3.1 8.0 7.6 0.16 12.2 1.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1229) Urocanase_C PF17392.2 PIK45582.1 - 2e-88 295.0 3.6 2.4e-88 294.7 3.6 1.0 1 0 0 1 1 1 1 Urocanase C-terminal domain zf-CCHC PF00098.23 PIK45583.1 - 1.1e-06 28.5 6.6 0.0079 16.2 0.2 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK45583.1 - 0.0077 16.2 5.9 0.19 11.7 0.9 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK45583.1 - 0.14 11.9 12.4 0.066 12.9 3.8 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Asp_protease_2 PF13650.6 PIK45583.1 - 0.16 12.6 0.1 0.37 11.5 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Urocanase PF01175.18 PIK45584.1 - 3.6e-61 206.5 0.0 4e-61 206.3 0.0 1.0 1 0 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_N PF17391.2 PIK45585.1 - 4.4e-61 204.2 0.2 6.1e-61 203.7 0.2 1.2 1 0 0 1 1 1 1 Urocanase N-terminal domain RhoGEF PF00621.20 PIK45586.1 - 2.2e-30 106.3 3.2 2.2e-30 106.3 3.2 2.0 2 1 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 PIK45586.1 - 0.0022 18.1 0.0 0.0047 17.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PWI PF01480.17 PIK45586.1 - 0.023 15.0 0.1 0.056 13.8 0.1 1.6 1 0 0 1 1 1 0 PWI domain IQ_SEC7_PH PF16453.5 PIK45586.1 - 0.027 14.4 0.1 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 PH domain PAD_M PF08527.10 PIK45586.1 - 0.15 11.7 0.1 20 4.8 0.0 2.3 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain E1-E2_ATPase PF00122.20 PIK45587.1 - 1.3e-35 122.5 11.6 1.4e-27 96.4 0.6 3.0 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 PIK45587.1 - 5.8e-21 75.0 1.7 5.8e-21 75.0 1.7 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 PIK45587.1 - 2.8e-18 65.8 0.0 5.7e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 PIK45587.1 - 1e-14 55.3 0.2 3.3e-13 50.4 0.2 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 PIK45587.1 - 5.8e-12 45.1 0.0 1.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 PIK45587.1 - 7.5e-07 29.1 0.1 7.4e-06 25.9 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Borrelia_REV PF03978.13 PIK45587.1 - 0.17 11.8 0.2 0.71 9.8 0.0 2.1 3 0 0 3 3 3 0 Borrelia burgdorferi REV protein Cadherin_C_2 PF16492.5 PIK45587.1 - 0.48 11.2 2.6 18 6.2 0.0 2.8 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Cyclin_N PF00134.23 PIK45588.1 - 1.7e-24 86.0 1.3 2.9e-24 85.2 0.5 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK45588.1 - 3.9e-08 33.4 1.1 1.3e-07 31.7 0.0 2.4 4 0 0 4 4 4 1 Cyclin, C-terminal domain SHQ1 PF04925.15 PIK45589.1 - 2.2e-38 131.6 2.3 8.2e-24 84.1 0.4 2.3 1 1 1 2 2 2 2 SHQ1 protein Hist_deacetyl PF00850.19 PIK45590.1 - 1.2e-48 166.2 0.0 1.6e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF4883 PF16224.5 PIK45590.1 - 0.021 15.0 0.1 0.043 14.1 0.1 1.5 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) Glyco_transf_29 PF00777.18 PIK45591.1 - 1.5e-65 221.3 0.9 2.1e-65 220.8 0.4 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Pkinase PF00069.25 PIK45592.1 - 5.3e-53 180.1 0.0 8.9e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45592.1 - 2.9e-49 167.7 0.0 3.9e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 PIK45592.1 - 0.033 13.8 0.1 2.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PQQ_3 PF13570.6 PIK45592.1 - 0.036 14.6 0.1 17 6.1 0.0 3.6 4 0 0 4 4 4 0 PQQ-like domain Kdo PF06293.14 PIK45592.1 - 0.065 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RSN1_7TM PF02714.15 PIK45593.1 - 2.8e-48 164.6 25.6 2.8e-48 164.6 25.6 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 PIK45593.1 - 1.7e-38 132.6 0.0 2.4e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF4810 PF16068.5 PIK45593.1 - 0.1 13.2 0.0 0.34 11.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) Pkinase PF00069.25 PIK45594.1 - 1.8e-23 83.3 0.1 2.9e-21 76.0 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45594.1 - 8e-18 64.6 0.0 2.9e-15 56.3 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.22 PIK45594.1 - 0.021 14.4 0.2 0.033 13.8 0.2 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK45594.1 - 0.068 12.5 0.1 0.15 11.4 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK45594.1 - 0.078 11.7 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FemAB_like PF04339.12 PIK45594.1 - 0.083 12.0 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition APH PF01636.23 PIK45594.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Golgin_A5 PF09787.9 PIK45595.1 - 3e-85 286.4 35.0 3e-85 286.4 35.0 3.1 1 1 2 3 3 3 1 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 PIK45595.1 - 0.0013 18.8 20.0 0.0013 18.8 20.0 5.4 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 PIK45595.1 - 0.011 15.5 15.0 0.011 15.5 15.0 5.0 1 1 2 4 4 4 0 Domain of unknown function (DUF4201) PKcGMP_CC PF16808.5 PIK45595.1 - 0.059 13.2 0.4 0.059 13.2 0.4 5.1 7 0 0 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Atg14 PF10186.9 PIK45595.1 - 7.5 5.5 77.3 8.1 5.4 17.6 4.4 1 1 3 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_12 PF13424.6 PIK45596.1 - 4.1e-11 43.0 0.1 2.6e-05 24.4 0.1 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45596.1 - 2.8e-09 36.4 2.1 0.096 12.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45596.1 - 1.1e-08 34.6 4.8 0.13 12.5 0.3 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK45596.1 - 5e-08 32.4 6.8 0.0029 17.4 0.8 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK45596.1 - 6.4e-07 29.0 0.2 1.9 8.7 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK45596.1 - 0.00025 20.8 0.1 0.034 14.0 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Consortin_C PF15281.6 PIK45596.1 - 0.00064 19.7 5.7 0.00064 19.7 5.7 2.8 2 1 0 2 2 2 1 Consortin C-terminus TPR_11 PF13414.6 PIK45596.1 - 0.0025 17.4 0.3 2.5 7.8 0.1 2.8 3 0 0 3 3 3 2 TPR repeat TPR_MalT PF17874.1 PIK45596.1 - 0.18 11.1 0.0 5.5 6.3 0.0 2.0 1 1 1 2 2 2 0 MalT-like TPR region BIRC6 PF12356.8 PIK45596.1 - 0.36 10.2 4.6 0.13 11.7 0.8 2.0 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 FMN_dh PF01070.18 PIK45597.1 - 8.5e-135 449.3 0.0 9.6e-135 449.1 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK45597.1 - 2.3e-08 33.5 0.9 4.5e-08 32.5 0.9 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK45597.1 - 6.9e-05 22.1 0.3 0.00011 21.5 0.3 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase TMP-TENI PF02581.17 PIK45597.1 - 0.076 12.3 0.0 0.69 9.2 0.0 2.5 3 0 0 3 3 3 0 Thiamine monophosphate synthase LRR_4 PF12799.7 PIK45598.1 - 0.0008 19.7 0.1 0.18 12.3 0.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK45598.1 - 0.0029 17.9 1.2 11 7.0 0.1 3.6 3 0 0 3 3 3 2 Leucine Rich Repeat SNAP PF14938.6 PIK45599.1 - 2.2e-109 365.2 26.9 2.5e-109 365.1 26.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 PIK45599.1 - 7.6e-07 29.3 13.9 0.038 14.3 0.5 4.6 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK45599.1 - 3.4e-05 23.6 6.3 6.2 7.1 0.1 6.2 4 1 1 5 5 5 1 Tetratricopeptide repeat NSF PF02071.20 PIK45599.1 - 3.7e-05 23.7 32.7 0.47 11.4 1.0 8.3 8 1 1 9 9 9 2 Aromatic-di-Alanine (AdAR) repeat Sel1 PF08238.12 PIK45599.1 - 5.6e-05 23.7 4.8 1.4 9.7 0.0 4.3 4 0 0 4 4 4 2 Sel1 repeat TPR_6 PF13174.6 PIK45599.1 - 0.0002 21.8 12.2 0.62 10.8 0.2 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45599.1 - 0.00022 21.2 14.2 1.1 9.6 0.2 5.9 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45599.1 - 0.00043 20.2 16.6 0.2 11.9 0.1 6.1 5 2 1 6 6 6 2 Tetratricopeptide repeat DUF2076 PF09849.9 PIK45599.1 - 0.001 19.1 1.5 0.0021 18.2 1.5 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF4368 PF14287.6 PIK45599.1 - 0.011 16.0 0.2 0.84 10.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) Spatacsin_C PF14649.6 PIK45599.1 - 0.011 14.8 16.7 0.013 14.7 1.1 3.2 1 1 2 3 3 3 0 Spatacsin C-terminus TPR_10 PF13374.6 PIK45599.1 - 0.015 15.1 6.2 39 4.3 0.0 5.1 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK45599.1 - 0.038 13.8 16.4 0.59 10.0 0.2 5.6 3 2 2 5 5 5 0 Tetratricopeptide repeat NRBF2_MIT PF17169.4 PIK45599.1 - 0.88 9.8 6.8 0.78 10.0 0.6 3.3 1 1 2 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 Exonuc_VII_S PF02609.16 PIK45599.1 - 0.91 9.6 6.7 11 6.1 0.0 3.7 4 0 0 4 4 4 0 Exonuclease VII small subunit TPR_11 PF13414.6 PIK45599.1 - 5 6.9 16.6 3.8 7.3 0.1 5.1 5 1 1 6 6 5 0 TPR repeat Y_phosphatase PF00102.27 PIK45600.1 - 4.8e-60 203.0 0.1 9.9e-60 202.0 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.18 PIK45600.1 - 5.2e-19 68.8 2.1 1.1e-18 67.7 0.9 2.3 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 PIK45600.1 - 1.3e-12 47.9 0.2 3.7e-12 46.5 0.1 1.8 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.10 PIK45600.1 - 0.00098 19.0 0.2 0.0023 17.8 0.2 1.7 1 0 0 1 1 1 1 FERM N-terminal domain DSPc PF00782.20 PIK45600.1 - 0.022 14.6 0.0 0.054 13.3 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK45600.1 - 0.039 13.9 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family GAS PF13851.6 PIK45601.1 - 7e-05 22.3 38.0 7e-05 22.3 38.0 23.6 2 1 18 24 24 24 7 Growth-arrest specific micro-tubule binding SlyX PF04102.12 PIK45601.1 - 0.00017 22.1 5.9 0.00017 22.1 5.9 36.0 20 11 18 40 40 40 4 SlyX Lebercilin PF15619.6 PIK45601.1 - 0.0025 17.5 51.2 0.0025 17.5 51.2 24.1 4 3 16 23 23 23 7 Ciliary protein causing Leber congenital amaurosis disease PKcGMP_CC PF16808.5 PIK45601.1 - 0.0045 16.8 2.5 0.0045 16.8 2.5 27.7 30 4 3 33 33 33 4 Coiled-coil N-terminus of cGMP-dependent protein kinase CENP-F_N PF10481.9 PIK45602.1 - 3.7e-35 122.1 25.7 3.7e-35 122.1 25.7 6.9 2 2 4 6 6 6 2 Cenp-F N-terminal domain ADIP PF11559.8 PIK45602.1 - 0.014 15.5 16.6 0.014 15.5 16.6 9.9 3 2 7 10 10 10 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 PIK45602.1 - 0.44 10.8 169.9 0.36 11.0 18.7 8.0 2 2 6 8 8 8 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK45602.1 - 8.3 6.8 165.6 0.3 11.5 17.4 6.7 2 2 4 6 6 6 0 Fez1 Exo_endo_phos PF03372.23 PIK45603.1 - 0.00048 19.7 0.0 0.00085 18.9 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK45604.1 - 1.1e-09 38.1 0.1 1.4e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK45605.1 - 0.00031 20.3 0.0 0.00037 20.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK45606.1 - 1.3e-18 67.4 1.4 4.4e-05 23.1 0.0 6.4 5 1 0 5 5 5 5 Endonuclease/Exonuclease/phosphatase family M157 PF11624.8 PIK45606.1 - 0.037 13.4 0.0 19 4.5 0.0 3.9 4 0 0 4 4 4 0 MHC class I-like protein M157 Exo_endo_phos PF03372.23 PIK45607.1 - 4.4e-09 36.2 0.0 7.2e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK45608.1 - 0.0021 17.6 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Toprim_4 PF13662.6 PIK45608.1 - 0.18 12.3 0.0 0.33 11.5 0.0 1.4 1 0 0 1 1 1 0 Toprim domain WD40 PF00400.32 PIK45609.1 - 1.8e-38 129.8 29.6 1.1e-07 32.5 0.5 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 PIK45609.1 - 1.1e-11 44.4 0.6 6.1e-11 42.0 0.2 2.4 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 PIK45609.1 - 3.7e-08 33.5 3.2 0.0022 18.3 0.0 5.1 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK45609.1 - 4.8e-08 32.7 5.0 0.0018 17.7 1.4 2.2 1 1 1 2 2 2 2 WD40-like domain F-box PF00646.33 PIK45609.1 - 2.4e-07 30.5 0.5 1.1e-06 28.4 0.2 2.1 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 PIK45609.1 - 3.4e-05 22.7 2.2 0.043 12.5 0.1 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 PIK45609.1 - 9.2e-05 21.5 4.2 0.018 13.9 0.1 3.2 2 1 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain SH3_15 PF18346.1 PIK45609.1 - 0.064 13.6 0.1 0.18 12.2 0.1 1.8 1 0 0 1 1 1 0 Mind bomb SH3 repeat domain RVT_1 PF00078.27 PIK45610.1 - 1.2e-23 83.8 0.0 1.5e-23 83.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK45611.1 - 2.5e-13 50.0 8.3 3.4e-13 49.5 8.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK45611.1 - 0.001 18.5 0.7 0.0015 17.9 0.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 PIK45612.1 - 1.7e-40 139.0 11.3 2.2e-40 138.6 11.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK45612.1 - 1.7e-11 44.2 12.4 2.3e-11 43.8 12.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK45612.1 - 2.9e-08 33.4 4.1 2.9e-08 33.4 4.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK45612.1 - 7.1e-08 32.1 10.4 9.8e-08 31.7 10.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CbtA PF09490.10 PIK45612.1 - 0.061 13.1 1.3 0.28 10.9 0.1 2.2 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) 7tm_1 PF00001.21 PIK45613.1 - 2.5e-15 56.5 7.7 3.4e-15 56.1 7.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK45613.1 - 0.00025 20.5 0.6 0.00039 19.9 0.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK45613.1 - 0.001 18.5 0.4 0.0013 18.2 0.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TMEM82 PF15816.5 PIK45613.1 - 0.047 12.7 0.0 0.06 12.3 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 82 PRT_C PF08372.10 PIK45613.1 - 1.8 8.3 4.7 4.1 7.2 3.4 2.1 1 1 1 2 2 2 0 Plant phosphoribosyltransferase C-terminal FAST_1 PF06743.15 PIK45614.1 - 0.075 13.0 1.4 15 5.6 0.1 3.3 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 DUF547 PF04784.14 PIK45615.1 - 1.6e-16 60.5 0.0 3.6e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF547 GTP_EFTU PF00009.27 PIK45617.1 - 8.2e-23 81.0 0.0 1.4e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 PIK45617.1 - 0.0024 18.2 0.0 0.0095 16.3 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Dynamin_N PF00350.23 PIK45617.1 - 0.0096 16.0 0.3 0.42 10.7 0.3 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 PIK45617.1 - 0.05 13.7 0.1 0.15 12.2 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase zf-CCCH_2 PF14608.6 PIK45618.1 - 3.7e-16 58.9 53.9 4.4e-05 23.8 6.2 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.17 PIK45618.1 - 0.00016 21.9 0.2 0.00035 20.8 0.2 1.5 1 0 0 1 1 1 1 PWI domain zf-CCCH_4 PF18044.1 PIK45618.1 - 0.0017 18.1 13.3 0.0026 17.5 2.9 4.7 4 1 1 5 5 4 2 CCCH-type zinc finger zf-CCCH PF00642.24 PIK45618.1 - 0.0081 16.1 10.3 0.014 15.3 1.7 4.9 5 1 1 6 6 6 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK45618.1 - 0.04 14.0 0.9 0.04 14.0 0.9 5.8 8 0 0 8 8 8 0 Zinc finger domain EST1 PF10374.9 PIK45618.1 - 0.55 10.9 7.1 0.072 13.7 1.2 2.6 2 0 0 2 2 2 0 Telomerase activating protein Est1 CSG2 PF16965.5 PIK45618.1 - 1.8 7.4 4.7 0.32 9.9 0.8 1.7 2 0 0 2 2 2 0 Ceramide synthase regulator Disintegrin PF00200.23 PIK45618.1 - 2 9.3 18.8 1.4 9.7 1.8 2.9 2 0 0 2 2 2 0 Disintegrin zf-C3H1 PF10650.9 PIK45618.1 - 7.4 6.4 8.5 31 4.4 0.2 3.6 3 0 0 3 3 3 0 Putative zinc-finger domain Opy2 PF09463.10 PIK45618.1 - 8.6 6.8 11.7 22 5.5 1.5 3.1 1 1 1 2 2 2 0 Opy2 protein 7tm_1 PF00001.21 PIK45620.1 - 4.8e-14 52.3 0.5 6.5e-14 51.9 0.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK45620.1 - 0.0015 17.9 0.7 0.0023 17.4 0.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK45620.1 - 0.075 12.6 6.3 0.1 12.2 6.3 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 2-Hacid_dh_C PF02826.19 PIK45621.1 - 1.6e-08 34.1 0.0 1.8e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain V-set PF07686.17 PIK45622.1 - 3e-10 40.2 1.0 0.0042 17.2 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin V-set domain EGF PF00008.27 PIK45622.1 - 9.7e-09 35.4 9.4 2.1e-08 34.3 9.4 1.6 1 0 0 1 1 1 1 EGF-like domain ig PF00047.25 PIK45622.1 - 6.6e-08 32.6 2.4 0.0059 16.7 0.0 4.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_3 PF13927.6 PIK45622.1 - 4.6e-06 27.1 3.1 0.074 13.7 0.0 4.8 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.6 PIK45622.1 - 0.00088 19.6 1.6 0.16 12.4 0.0 3.8 3 1 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK45622.1 - 0.012 15.6 0.1 2.8 8.1 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin I-set domain DUF3844 PF12955.7 PIK45622.1 - 0.017 15.3 0.7 0.055 13.6 0.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) EphA2_TM PF14575.6 PIK45622.1 - 0.036 15.0 0.0 0.17 12.8 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEMspv1-c74-12 PF11044.8 PIK45622.1 - 0.062 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Big_11 PF18200.1 PIK45622.1 - 0.079 12.9 0.3 9.8 6.2 0.0 3.4 4 0 0 4 4 4 0 Bacterial Ig-like domain cEGF PF12662.7 PIK45622.1 - 0.3 11.1 5.6 0.43 10.6 3.8 2.3 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK45622.1 - 0.79 10.1 10.5 2.3 8.7 10.5 1.9 1 0 0 1 1 1 0 EGF-like domain Sema PF01403.19 PIK45623.1 - 1.8e-17 63.3 0.0 2.9e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Sema domain UCH PF00443.29 PIK45625.1 - 1e-15 57.9 1.7 1e-15 57.9 1.7 2.3 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 PIK45626.1 - 3.7e-38 131.5 0.1 4.8e-38 131.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK45626.1 - 2.3e-14 53.8 7.0 5.3e-11 42.7 4.4 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 PIK45626.1 - 0.0017 18.1 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal Rhomboid PF01694.22 PIK45627.1 - 1e-27 97.0 9.4 1e-27 97.0 9.4 1.8 3 0 0 3 3 3 1 Rhomboid family Rhomboid_SP PF12595.8 PIK45627.1 - 1.9e-15 56.8 8.4 1e-11 44.7 2.0 2.6 1 1 1 2 2 2 2 Rhomboid serine protease RNA_polI_A34 PF08208.11 PIK45627.1 - 0.036 14.2 6.0 0.063 13.4 6.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 tRNA_synt_1c_R2 PF04557.15 PIK45627.1 - 0.05 14.5 3.9 8.9 7.3 3.8 2.3 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 GtrA PF04138.14 PIK45627.1 - 0.081 13.2 1.6 0.2 11.9 1.6 1.6 1 0 0 1 1 1 0 GtrA-like protein AIM3 PF17096.5 PIK45627.1 - 2.8 8.9 6.1 25 5.9 3.5 2.5 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 RA PF00788.23 PIK45628.1 - 2e-08 34.8 0.5 1.7e-07 31.7 0.5 2.4 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain CemA PF03040.14 PIK45628.1 - 0.052 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 CemA family fn3 PF00041.21 PIK45629.1 - 5e-11 42.8 0.2 9.6e-11 41.9 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ank_4 PF13637.6 PIK45629.1 - 5.4e-06 26.9 0.0 1.1e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Interfer-bind PF09294.10 PIK45629.1 - 0.0022 18.3 0.0 0.0094 16.3 0.0 2.0 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Ank_2 PF12796.7 PIK45629.1 - 0.006 17.2 0.0 0.016 15.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Pur_ac_phosph_N PF16656.5 PIK45629.1 - 0.0073 16.9 0.8 0.025 15.2 0.8 1.9 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ank_5 PF13857.6 PIK45629.1 - 0.0086 16.4 1.0 0.19 12.1 0.2 2.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK45629.1 - 0.16 12.6 0.0 1.2 9.9 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat TPMT PF05724.11 PIK45631.1 - 0.015 15.0 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) RVT_1 PF00078.27 PIK45632.1 - 1.5e-06 27.9 0.0 3.9e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK45632.1 - 4.6e-06 26.9 0.1 2.6e-05 24.5 0.1 2.2 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK45632.1 - 0.00035 20.4 0.2 0.00063 19.6 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK45632.1 - 0.014 15.4 0.0 0.084 12.9 0.0 2.2 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK45634.1 - 1.5e-06 27.9 0.0 2.8e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-DBF PF07535.12 PIK45635.1 - 2e-16 59.8 1.4 3.8e-16 58.9 1.4 1.5 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 PIK45635.1 - 0.02 15.2 0.0 0.055 13.8 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain HrpB7 PF09486.10 PIK45635.1 - 0.029 14.7 5.9 0.069 13.5 5.9 1.6 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF4167 PF13763.6 PIK45635.1 - 0.29 11.3 2.1 10 6.3 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4167) DNA_pol3_a_NII PF11490.8 PIK45635.1 - 0.72 9.8 7.8 1.9 8.4 7.8 1.7 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Pheromone PF08015.11 PIK45635.1 - 0.91 10.6 5.1 3.3 8.8 0.9 4.0 2 0 0 2 2 2 0 Fungal mating-type pheromone Fibrinogen_C PF00147.18 PIK45636.1 - 1.3e-55 188.6 0.5 2.1e-55 187.9 0.5 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kazal_1 PF00050.21 PIK45636.1 - 2.2e-21 75.6 42.2 5.7e-09 35.8 2.5 4.7 4 1 1 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK45636.1 - 1.3e-18 66.9 25.7 4.4e-08 33.1 3.7 5.7 6 0 0 6 6 6 3 Kazal-type serine protease inhibitor domain VWC PF00093.18 PIK45636.1 - 0.028 14.7 7.9 0.028 14.7 7.9 4.8 2 1 1 3 3 3 0 von Willebrand factor type C domain MOZART1 PF12554.8 PIK45636.1 - 0.16 11.8 1.5 56 3.6 0.0 3.3 3 0 0 3 3 3 0 Mitotic-spindle organizing gamma-tubulin ring associated Fibrinogen_C PF00147.18 PIK45637.1 - 8.7e-55 185.9 0.1 1.3e-54 185.3 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kazal_1 PF00050.21 PIK45637.1 - 5.1e-11 42.4 3.5 5.1e-11 42.4 3.5 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK45637.1 - 1.5e-10 41.0 3.8 1.5e-10 41.0 3.8 2.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain fn3 PF00041.21 PIK45637.1 - 0.00052 20.3 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF1682 PF07946.14 PIK45638.1 - 7.6e-47 160.1 0.0 7.6e-47 160.1 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) Cupin_8 PF13621.6 PIK45638.1 - 0.036 13.8 1.3 0.59 9.8 1.3 2.2 1 1 0 1 1 1 0 Cupin-like domain NCD1 PF04904.13 PIK45638.1 - 0.12 12.3 0.1 0.85 9.7 0.1 2.1 2 0 0 2 2 2 0 NAB conserved region 1 (NCD1) SDA1 PF05285.12 PIK45638.1 - 3.1 7.2 13.3 4 6.8 13.3 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 PIK45638.1 - 4 5.6 7.3 4.9 5.3 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1682 PF07946.14 PIK45639.1 - 3.8e-23 82.2 11.6 4.5e-23 82.0 11.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) PBP_sp32 PF07222.12 PIK45639.1 - 0.011 15.3 2.4 0.012 15.1 2.4 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Methyltransf_2 PF00891.18 PIK45639.1 - 0.02 14.2 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Presenilin PF01080.17 PIK45639.1 - 5.8 5.6 4.8 6.5 5.4 4.8 1.1 1 0 0 1 1 1 0 Presenilin Integrin_alpha2 PF08441.12 PIK45641.1 - 5.3e-46 157.5 0.0 6.4e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK45641.1 - 3.1e-15 56.0 15.3 8.8e-08 32.1 0.1 3.7 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 PIK45641.1 - 1.3e-06 28.9 14.0 0.00016 22.2 8.0 3.5 3 1 1 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK45641.1 - 0.00024 21.3 5.3 1.2 9.4 0.0 3.5 3 0 0 3 3 3 2 FG-GAP repeat MAP17 PF15807.5 PIK45642.1 - 0.0013 19.0 0.1 0.0019 18.4 0.1 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4834 PF16118.5 PIK45642.1 - 0.0017 19.3 0.2 0.0025 18.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Integrin_alpha PF00357.20 PIK45642.1 - 0.0028 17.5 0.9 0.0083 16.0 0.9 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FAM176 PF14851.6 PIK45642.1 - 0.0036 17.0 0.0 0.0054 16.4 0.0 1.2 1 0 0 1 1 1 1 FAM176 family LYRIC PF15686.5 PIK45642.1 - 0.0061 16.2 0.0 0.0079 15.8 0.0 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family MMM1 PF10296.9 PIK45642.1 - 0.01 14.9 0.1 0.013 14.6 0.1 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 PBP1_TM PF14812.6 PIK45642.1 - 0.014 15.7 0.8 0.014 15.7 0.8 1.7 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SID-1_RNA_chan PF13965.6 PIK45642.1 - 0.016 13.7 0.1 0.018 13.5 0.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Collectrin PF16959.5 PIK45642.1 - 0.02 14.6 1.1 0.031 14.1 1.1 1.4 1 0 0 1 1 1 0 Renal amino acid transporter Adeno_E3_CR2 PF02439.15 PIK45642.1 - 0.021 14.6 1.7 0.035 13.8 1.7 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Protocadherin PF08374.11 PIK45642.1 - 0.026 14.5 0.1 0.034 14.1 0.1 1.2 1 0 0 1 1 1 0 Protocadherin Tmemb_9 PF05434.11 PIK45642.1 - 0.042 13.7 0.2 0.061 13.2 0.2 1.2 1 0 0 1 1 1 0 TMEM9 DUF3899 PF13038.6 PIK45642.1 - 0.042 14.3 1.3 0.27 11.8 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) Shisa PF13908.6 PIK45642.1 - 0.043 14.0 0.0 0.047 13.9 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator LRR19-TM PF15176.6 PIK45642.1 - 0.046 13.7 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF997 PF06196.12 PIK45642.1 - 0.076 13.0 1.4 0.11 12.5 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF997) EphA2_TM PF14575.6 PIK45642.1 - 0.082 13.8 0.0 0.14 13.1 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3328 PF11807.8 PIK45642.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) ASFV_J13L PF05568.11 PIK45642.1 - 0.14 11.9 0.3 0.18 11.5 0.3 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein ODV-E18 PF10717.9 PIK45642.1 - 0.5 10.3 3.3 0.79 9.6 3.3 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 CO_deh_flav_C PF03450.17 PIK45643.1 - 4.5e-22 78.2 0.0 8.2e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain FAD_binding_5 PF00941.21 PIK45643.1 - 3.5e-17 62.7 0.0 4.9e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 PIK45643.1 - 1.2e-15 57.8 0.0 2.4e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 PIK45644.1 - 5.6e-13 48.7 1.5 6.3e-13 48.5 0.1 1.8 2 0 0 2 2 2 1 [2Fe-2S] binding domain HN PF00423.19 PIK45645.1 - 0.023 13.5 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase wnt PF00110.19 PIK45647.1 - 1.2e-115 386.4 14.0 1.3e-115 386.2 14.0 1.0 1 0 0 1 1 1 1 wnt family Arm PF00514.23 PIK45648.1 - 4.1e-39 131.4 24.6 1.2e-06 28.4 0.2 11.1 12 0 0 12 12 12 7 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 PIK45648.1 - 2.7e-09 36.1 5.1 2.5e-07 29.6 2.5 3.3 3 1 0 3 3 3 1 Adaptin N terminal region HEAT_2 PF13646.6 PIK45648.1 - 8.4e-07 29.3 2.9 0.0017 18.7 0.6 4.6 3 1 1 4 4 4 1 HEAT repeats KAP PF05804.12 PIK45648.1 - 8.8e-07 27.5 5.4 0.051 11.7 2.6 4.0 2 1 0 4 4 4 2 Kinesin-associated protein (KAP) Cnd1 PF12717.7 PIK45648.1 - 2.4e-06 27.7 2.8 0.0095 16.0 0.6 4.0 3 2 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK45648.1 - 3.3e-05 24.3 3.1 2.8 8.5 0.0 5.1 3 1 1 4 4 4 2 HEAT-like repeat Atx10homo_assoc PF09759.9 PIK45648.1 - 0.00015 21.7 2.6 0.0091 16.0 0.5 4.0 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 PIK45648.1 - 0.0005 20.1 4.3 6 7.4 0.0 5.8 6 0 0 6 6 6 1 HEAT repeat Pes-10 PF07149.11 PIK45648.1 - 0.0039 16.3 0.7 2.1 7.3 0.1 2.6 2 1 1 3 3 3 2 Pes-10 DUF3361 PF11841.8 PIK45648.1 - 0.0039 17.1 5.7 3.7 7.5 0.0 4.1 4 1 1 5 5 5 2 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 PIK45648.1 - 0.011 15.8 2.6 9.3 6.4 0.0 4.2 3 1 2 5 5 5 0 V-ATPase subunit H RasGEF_N_2 PF14663.6 PIK45648.1 - 1.4 9.4 9.8 41 4.6 0.1 5.5 5 2 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TEX19 PF15553.6 PIK45649.1 - 0.036 14.0 0.1 0.057 13.4 0.1 1.4 1 1 0 1 1 1 0 Testis-expressed protein 19 KRAP_IP3R_bind PF14722.6 PIK45650.1 - 7.1e-11 42.0 0.0 2.1e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Raffinose_syn PF05691.12 PIK45651.1 - 0.04 11.7 0.2 0.041 11.7 0.2 1.0 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 ArenaCapSnatch PF17296.2 PIK45651.1 - 0.074 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Arenavirus cap snatching domain P21-Arc PF04062.14 PIK45652.1 - 6e-43 146.9 0.0 6.8e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit BP28CT PF08146.12 PIK45653.1 - 0.072 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 BP28CT (NUC211) domain Fez1 PF06818.15 PIK45654.1 - 4.3e-06 27.3 37.6 1.1e-05 25.9 15.2 3.2 1 1 2 3 3 3 2 Fez1 ALIX_LYPXL_bnd PF13949.6 PIK45654.1 - 0.0023 17.3 42.0 0.0036 16.6 27.9 2.2 1 1 1 2 2 2 1 ALIX V-shaped domain binding to HIV TPR_MLP1_2 PF07926.12 PIK45654.1 - 0.0038 17.3 52.4 0.11 12.6 11.7 4.4 2 1 2 4 4 4 3 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 PIK45654.1 - 0.0063 14.1 39.3 0.0097 13.5 39.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) COG5 PF10392.9 PIK45654.1 - 0.0074 16.5 7.0 0.0074 16.5 7.0 3.5 2 1 0 3 3 3 1 Golgi transport complex subunit 5 SOGA PF11365.8 PIK45654.1 - 0.033 15.3 44.1 0.79 10.9 6.8 4.8 2 1 3 5 5 5 0 Protein SOGA Spc7 PF08317.11 PIK45654.1 - 0.042 12.7 57.1 0.016 14.1 29.8 3.4 2 1 2 4 4 4 0 Spc7 kinetochore protein Rootletin PF15035.6 PIK45654.1 - 0.078 13.0 52.6 0.32 11.0 22.5 3.7 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion UPF0242 PF06785.11 PIK45654.1 - 0.11 12.6 0.2 0.11 12.6 0.2 4.4 1 1 2 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 PIK45654.1 - 0.13 11.6 62.3 0.046 13.1 18.1 4.3 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 PIK45654.1 - 0.2 11.3 60.9 0.01 15.5 33.1 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease FliJ PF02050.16 PIK45654.1 - 0.4 10.9 36.7 0.27 11.4 12.7 3.8 2 1 0 3 3 3 0 Flagellar FliJ protein Rab5-bind PF09311.11 PIK45654.1 - 0.4 10.0 48.8 56 3.0 48.5 3.3 1 1 0 1 1 1 0 Rabaptin-like protein HAP1_N PF04849.13 PIK45654.1 - 0.47 9.6 58.1 3.3 6.8 0.3 3.4 2 1 1 3 3 3 0 HAP1 N-terminal conserved region Fib_alpha PF08702.10 PIK45654.1 - 0.49 10.6 46.8 0.023 14.9 9.4 4.1 2 1 1 4 4 4 0 Fibrinogen alpha/beta chain family FPP PF05911.11 PIK45654.1 - 1 7.5 47.6 0.4 8.8 42.4 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil ERM PF00769.19 PIK45654.1 - 1 9.1 50.7 3.1 7.6 28.9 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family DUF2935 PF11155.8 PIK45654.1 - 1.5 9.2 8.8 23 5.3 0.0 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Myosin_tail_1 PF01576.19 PIK45654.1 - 1.6 6.4 63.1 0.026 12.3 18.1 2.8 2 1 1 3 3 3 0 Myosin tail ATG16 PF08614.11 PIK45654.1 - 2.2 8.4 55.6 1.4 9.1 36.3 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.11 PIK45654.1 - 3.3 8.3 32.7 6.7 7.3 3.1 4.6 2 1 2 4 4 4 0 Syntaxin 6, N-terminal WD40_alt PF14077.6 PIK45654.1 - 3.5 7.6 6.0 3.5 7.6 0.7 3.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif FUSC PF04632.12 PIK45654.1 - 4.4 5.7 10.1 0.77 8.2 4.3 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein family CALCOCO1 PF07888.11 PIK45654.1 - 5.6 5.7 54.7 0.22 10.4 36.2 2.5 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.8 PIK45654.1 - 6.7 6.8 58.0 0.1 12.7 13.2 4.7 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding SET PF00856.28 PIK45655.1 - 8.4e-19 68.6 4.8 2e-18 67.4 0.0 3.0 2 2 0 2 2 2 1 SET domain DUF836 PF05768.14 PIK45655.1 - 0.15 12.5 0.3 9.1 6.8 0.0 3.1 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) LAP1C PF05609.12 PIK45655.1 - 0.88 8.6 12.5 1.1 8.2 12.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MazG-like PF12643.7 PIK45656.1 - 1.2e-09 38.3 0.3 2.1e-09 37.5 0.3 1.4 1 0 0 1 1 1 1 MazG-like family MazG PF03819.17 PIK45656.1 - 0.00096 19.3 0.1 0.0018 18.4 0.1 1.4 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain Fer4 PF00037.27 PIK45657.1 - 6.8e-13 47.9 21.2 2.1e-08 33.7 4.5 2.6 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 PIK45657.1 - 1.2e-12 48.2 10.5 2.3e-12 47.3 10.5 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 PIK45657.1 - 9.4e-11 42.5 6.5 4.3e-05 24.4 0.2 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 PIK45657.1 - 1.8e-08 34.4 10.3 3.4e-08 33.5 10.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 PIK45657.1 - 2.5e-08 33.9 20.9 5.9e-06 26.3 12.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 PIK45657.1 - 7.9e-08 32.3 34.0 1.7e-05 24.8 12.8 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 PIK45657.1 - 4.3e-07 29.7 17.8 0.00046 20.1 5.4 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 PIK45657.1 - 5.8e-07 29.9 18.4 0.00027 21.3 11.4 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 PIK45657.1 - 2.4e-06 27.3 12.5 0.0032 17.5 2.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 PIK45657.1 - 1.5e-05 25.2 12.0 0.00059 20.1 2.5 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 PIK45657.1 - 0.0028 18.2 13.2 0.043 14.3 12.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 PIK45657.1 - 0.022 15.3 14.8 0.86 10.2 4.3 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 PIK45657.1 - 0.2 12.7 16.3 0.4 11.7 4.1 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 PIK45657.1 - 0.25 11.5 10.1 2.6 8.2 1.2 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 PIK45657.1 - 0.53 10.4 6.2 1.5 9.0 0.8 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S c-SKI_SMAD_bind PF08782.10 PIK45657.1 - 1.2 9.4 8.5 2.5 8.4 0.5 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_22 PF17179.4 PIK45657.1 - 1.4 9.8 12.2 3 8.8 1.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain EPF PF17181.4 PIK45657.1 - 3.5 7.7 8.5 3.2 7.8 2.6 2.5 2 0 0 2 2 2 0 Epidermal patterning factor proteins Ran_BP1 PF00638.18 PIK45658.1 - 2.7e-48 163.3 0.6 2.7e-48 163.3 0.6 2.0 2 0 0 2 2 2 1 RanBP1 domain Lig_C PF18330.1 PIK45658.1 - 0.04 13.9 0.3 0.04 13.9 0.3 1.9 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region CDC45 PF02724.14 PIK45658.1 - 2.5 6.3 14.5 2.9 6.1 14.5 1.2 1 0 0 1 1 1 0 CDC45-like protein 7tm_1 PF00001.21 PIK45659.1 - 1.5e-36 126.1 14.6 2e-36 125.7 14.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK45659.1 - 1.2e-11 44.5 11.0 3.5e-11 43.0 11.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK45659.1 - 1.3e-06 28.3 22.7 1.6e-06 27.9 20.1 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK45659.1 - 7e-06 25.6 13.3 7.2e-06 25.6 12.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srd PF10317.9 PIK45659.1 - 7.4e-05 22.1 17.2 0.00024 20.4 17.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srd DUF5305 PF17231.2 PIK45659.1 - 0.044 13.2 0.1 0.076 12.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) BCDHK_Adom3 PF10436.9 PIK45660.1 - 1.9e-40 138.3 0.2 3.1e-40 137.7 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 PIK45660.1 - 2.8e-15 56.8 0.2 3.8e-13 49.9 0.2 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 PIK45660.1 - 6.2e-06 26.1 0.0 9.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PTR2 PF00854.21 PIK45662.1 - 5.9e-36 124.1 7.0 9.1e-36 123.5 7.0 1.2 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 PIK45662.1 - 0.016 14.2 26.7 0.036 13.0 26.7 1.7 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF2556 PF10831.8 PIK45662.1 - 0.04 13.9 1.7 0.39 10.7 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2556) YpmT PF17431.2 PIK45662.1 - 3.9 7.6 9.5 1.3e+02 2.7 9.0 3.0 1 1 0 1 1 1 0 Uncharacterized YmpT-like PTR2 PF00854.21 PIK45663.1 - 5.5e-44 150.6 4.1 1e-43 149.7 4.1 1.4 1 0 0 1 1 1 1 POT family Myb_DNA-bind_4 PF13837.6 PIK45664.1 - 0.00042 20.6 1.2 0.00042 20.6 1.2 2.4 2 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain UPF0242 PF06785.11 PIK45664.1 - 0.011 15.9 13.2 0.011 15.9 13.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spt20 PF12090.8 PIK45664.1 - 7.7 6.1 24.0 15 5.1 17.8 2.1 2 0 0 2 2 2 0 Spt20 family MAPEG PF01124.18 PIK45665.1 - 2.2e-24 85.8 0.4 2.7e-24 85.5 0.4 1.1 1 0 0 1 1 1 1 MAPEG family Cadherin PF00028.17 PIK45666.1 - 7.5e-21 74.4 0.9 3e-07 30.8 0.0 4.0 4 0 0 4 4 4 3 Cadherin domain Laminin_G_1 PF00054.23 PIK45666.1 - 7.6e-21 74.7 0.0 2.9e-20 72.8 0.0 2.1 2 0 0 2 2 2 1 Laminin G domain Laminin_G_2 PF02210.24 PIK45666.1 - 2.8e-19 69.9 0.0 7.6e-19 68.5 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain Cadherin_4 PF17803.1 PIK45666.1 - 0.017 15.8 0.9 10 6.8 0.0 3.0 2 0 0 2 2 2 0 Bacterial cadherin-like domain BRD4_CDT PF17105.5 PIK45667.1 - 7.4e-18 63.9 9.5 7.4e-18 63.9 9.5 3.4 1 1 1 2 2 1 1 C-terminal domain of bromodomain protein 4 SprA-related PF12118.8 PIK45667.1 - 0.018 14.2 20.2 0.022 13.9 20.2 1.1 1 0 0 1 1 1 0 SprA-related family FapA PF03961.13 PIK45667.1 - 0.12 11.0 10.8 0.14 10.8 10.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A eIF-3_zeta PF05091.12 PIK45667.1 - 0.27 10.1 16.0 0.31 10.0 16.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_11 PF13086.6 PIK45667.1 - 1.1 8.9 17.4 1.6 8.5 17.4 1.3 1 0 0 1 1 1 0 AAA domain DDHD PF02862.17 PIK45667.1 - 1.2 9.3 11.3 1.6 8.8 11.3 1.3 1 0 0 1 1 1 0 DDHD domain BAF1_ABF1 PF04684.13 PIK45667.1 - 2.7 7.0 18.0 3.2 6.7 18.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Dsh_C PF12316.8 PIK45667.1 - 2.7 8.3 14.2 6.8 7.0 11.5 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal V_ATPase_I PF01496.19 PIK45667.1 - 5.3 4.8 14.9 5.6 4.8 14.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 PIK45667.1 - 5.5 6.7 19.0 7.3 6.3 19.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 PIK45667.1 - 6.1 5.8 5.7 6.6 5.7 5.7 1.3 1 0 0 1 1 1 0 CLN3 protein Bromodomain PF00439.25 PIK45668.1 - 1.3e-41 140.6 1.7 1.1e-19 70.3 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 PIK45668.1 - 7.5e-29 99.7 0.2 7.5e-29 99.7 0.2 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation WD40 PF00400.32 PIK45669.1 - 5.4e-62 204.3 22.2 1.7e-09 38.1 0.2 7.5 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK45669.1 - 3.5e-27 94.5 1.6 3.9e-05 23.9 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK45669.1 - 6.3e-14 51.5 5.2 0.0052 15.5 0.0 4.8 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK45669.1 - 5.3e-13 49.3 0.8 2.5e-06 27.5 0.1 3.7 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 PIK45669.1 - 1.3e-07 31.2 0.2 0.00025 20.5 0.0 3.1 1 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 PIK45669.1 - 8.1e-06 25.0 5.8 0.31 10.0 0.8 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 PIK45669.1 - 9.1e-06 24.8 1.4 6.2 5.6 0.0 4.2 1 1 1 4 4 4 3 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 PIK45669.1 - 0.001 17.5 0.0 0.042 12.2 0.0 2.5 1 1 2 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 PIK45669.1 - 0.0044 16.1 0.0 0.21 10.6 0.0 2.7 1 1 1 3 3 3 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 PIK45669.1 - 0.014 14.0 0.0 0.62 8.5 0.0 2.4 1 1 0 1 1 1 0 Cytochrome D1 heme domain Kelch_6 PF13964.6 PIK45669.1 - 0.2 12.0 0.9 4.6 7.7 0.1 3.0 2 1 0 2 2 2 0 Kelch motif PD40 PF07676.12 PIK45669.1 - 0.3 11.1 1.1 90 3.2 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Palm_thioest PF02089.15 PIK45671.1 - 4e-64 216.8 0.1 4.7e-64 216.5 0.1 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 PIK45671.1 - 4.3e-08 32.9 0.0 6.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_2 PF01674.18 PIK45671.1 - 6.5e-05 22.6 0.0 0.00048 19.7 0.0 2.2 1 1 0 1 1 1 1 Lipase (class 2) PGAP1 PF07819.13 PIK45671.1 - 0.019 14.7 0.3 0.11 12.2 0.0 2.2 2 1 1 3 3 3 0 PGAP1-like protein ODR4-like PF14778.6 PIK45672.1 - 6.7e-92 308.3 0.0 7.9e-92 308.1 0.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 4-like PABP PF00658.18 PIK45673.1 - 6e-42 141.7 5.8 6.1e-15 55.2 0.3 3.1 3 0 0 3 3 3 3 Poly-adenylate binding protein, unique domain Exo84_C PF16528.5 PIK45673.1 - 0.079 12.8 1.4 0.24 11.2 0.3 1.8 1 1 1 2 2 2 0 Exocyst component 84 C-terminal Borrelia_orfA PF02414.15 PIK45673.1 - 0.17 11.5 0.4 0.22 11.1 0.4 1.1 1 0 0 1 1 1 0 Borrelia ORF-A T-box_assoc PF16176.5 PIK45674.1 - 0.038 14.1 1.7 0.05 13.7 1.7 1.1 1 0 0 1 1 1 0 T-box transcription factor-associated SPC25 PF06703.11 PIK45674.1 - 0.13 12.0 1.6 0.22 11.3 1.6 1.5 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Sushi PF00084.20 PIK45675.1 - 1.8e-12 47.6 21.0 6.9e-08 33.0 2.0 4.5 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) HYR PF02494.16 PIK45675.1 - 0.018 15.3 0.5 0.059 13.7 0.3 2.2 1 1 0 1 1 1 0 HYR domain EGF PF00008.27 PIK45676.1 - 4.9e-34 116.3 68.9 6e-09 36.0 10.5 6.6 6 1 0 6 6 6 5 EGF-like domain hEGF PF12661.7 PIK45676.1 - 2.2e-19 69.3 63.2 2.1e-07 31.3 7.6 7.8 6 1 0 6 6 6 5 Human growth factor-like EGF EGF_2 PF07974.13 PIK45676.1 - 1.1e-08 35.2 82.9 0.0038 17.6 4.9 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_3 PF12947.7 PIK45676.1 - 4e-07 30.1 54.9 0.0055 16.9 1.9 5.8 4 1 1 5 5 5 4 EGF domain EGF_CA PF07645.15 PIK45676.1 - 3.2e-05 24.0 80.0 0.00031 20.9 12.3 6.9 3 2 3 6 6 6 3 Calcium-binding EGF domain cEGF PF12662.7 PIK45676.1 - 0.00022 21.1 0.5 0.00022 21.1 0.5 8.0 6 2 0 6 6 6 2 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK45676.1 - 0.019 15.0 5.0 0.019 15.0 5.0 6.3 7 1 0 7 7 7 0 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK45676.1 - 0.044 14.1 4.7 0.044 14.1 4.7 5.6 5 0 0 5 5 5 0 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK45676.1 - 0.17 12.2 61.1 0.99 9.7 11.3 6.2 2 2 4 6 6 6 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 PIK45676.1 - 3.7 7.7 65.2 11 6.3 4.9 5.5 2 2 3 5 5 5 0 Laminin EGF domain Chibby PF14645.6 PIK45677.1 - 0.0037 17.7 0.1 1.4 9.3 0.2 2.3 1 1 1 2 2 2 2 Chibby family EGF PF00008.27 PIK45678.1 - 4.1e-42 142.1 97.1 2.1e-06 27.9 6.1 8.3 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK45678.1 - 1.5e-16 60.4 96.7 0.00048 20.7 4.5 10.7 9 1 0 9 9 9 7 Human growth factor-like EGF EGF_2 PF07974.13 PIK45678.1 - 0.00012 22.4 112.2 0.0035 17.7 8.3 8.0 8 0 0 8 8 8 6 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK45678.1 - 0.00041 20.6 2.1 0.00041 20.6 2.1 7.0 5 1 2 7 7 7 2 Pvs28 EGF domain EGF_CA PF07645.15 PIK45678.1 - 0.0014 18.8 8.6 0.0014 18.8 8.6 8.3 3 1 5 8 8 8 4 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK45678.1 - 0.0016 18.7 80.1 0.66 10.3 6.8 8.1 2 2 5 7 7 7 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK45678.1 - 3.4 7.9 80.1 0.45 10.8 5.0 9.0 8 6 0 8 8 8 0 EGF domain Skp1_POZ PF03931.15 PIK45679.1 - 0.053 13.7 0.1 0.29 11.3 0.0 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain DUF4218 PF13960.6 PIK45680.1 - 0.088 12.4 0.3 0.2 11.3 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Ephrin_rec_like PF07699.13 PIK45681.1 - 2.7e-11 43.0 7.2 6.7e-08 32.2 2.9 2.7 1 1 1 2 2 2 2 Putative ephrin-receptor like AMP-binding PF00501.28 PIK45682.1 - 6.2e-106 354.5 0.0 8.4e-106 354.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK45682.1 - 1.1e-10 42.4 0.0 2.8e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 PIK45682.1 - 0.065 13.6 0.0 0.59 10.5 0.0 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain LXG PF04740.12 PIK45683.1 - 0.0099 15.6 2.2 0.017 14.8 0.4 2.0 1 1 1 2 2 2 2 LXG domain of WXG superfamily Sec20 PF03908.13 PIK45683.1 - 0.018 15.0 0.8 0.018 15.0 0.8 2.0 2 0 0 2 2 2 0 Sec20 SLATT_6 PF18169.1 PIK45683.1 - 0.04 13.5 0.8 0.059 13.0 0.8 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF334 PF03904.13 PIK45683.1 - 0.068 12.7 5.4 0.1 12.1 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) ECH_2 PF16113.5 PIK45683.1 - 0.11 11.9 3.2 0.16 11.4 1.2 1.7 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase ALMT PF11744.8 PIK45683.1 - 0.12 11.1 2.2 0.16 10.8 2.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec34 PF04136.15 PIK45683.1 - 0.73 9.7 5.5 0.23 11.4 1.1 1.9 2 1 1 3 3 3 0 Sec34-like family hEGF PF12661.7 PIK45684.1 - 0.0002 21.9 8.1 0.00068 20.2 8.1 2.0 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK45684.1 - 0.00021 21.6 14.0 0.00021 21.6 14.0 2.2 2 1 0 2 2 2 1 EGF-like domain Laminin_EGF PF00053.24 PIK45684.1 - 0.11 12.7 9.7 0.19 11.9 8.7 2.0 1 1 0 1 1 1 0 Laminin EGF domain DSL PF01414.19 PIK45684.1 - 0.73 10.2 9.3 0.33 11.3 6.9 1.6 2 0 0 2 2 2 0 Delta serrate ligand EGF PF00008.27 PIK45684.1 - 2.7 8.4 17.9 0.19 12.1 12.5 2.0 2 0 0 2 2 2 0 EGF-like domain fn3 PF00041.21 PIK45685.1 - 2.1e-10 40.8 0.6 1.8e-06 28.2 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK45685.1 - 0.012 16.2 0.2 0.58 10.8 0.0 2.5 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain DUF4945 PF16303.5 PIK45685.1 - 0.069 13.1 0.1 3.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4945) Y_phosphatase PF00102.27 PIK45686.1 - 1.9e-71 240.3 0.5 2.8e-48 164.5 0.0 2.0 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 PIK45686.1 - 0.00065 19.3 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 PIK45686.1 - 0.049 13.4 0.1 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK45686.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family ArgoN PF16486.5 PIK45686.1 - 0.12 12.9 0.2 0.28 11.8 0.2 1.5 1 0 0 1 1 1 0 N-terminal domain of argonaute RT_RNaseH PF17917.1 PIK45687.1 - 2e-20 73.0 0.0 4.7e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK45687.1 - 5.8e-17 61.6 0.0 1.6e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK45687.1 - 1.1e-15 57.8 0.0 2.4e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK45687.1 - 6.6e-15 55.0 0.1 6.6e-15 55.0 0.1 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK45687.1 - 7.4e-15 55.1 0.0 1.8e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK45687.1 - 9.3e-05 22.7 0.0 0.00039 20.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK45687.1 - 0.0064 17.0 0.0 0.02 15.5 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK45687.1 - 6.4 7.0 9.6 0.11 12.7 2.0 2.2 2 0 0 2 2 2 0 Zinc knuckle Y_phosphatase PF00102.27 PIK45688.1 - 2.4e-29 102.5 0.1 3e-29 102.3 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK45688.1 - 0.12 12.2 0.1 0.18 11.6 0.1 1.5 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK45689.1 - 1.5e-153 509.1 5.7 7.6e-81 271.1 0.3 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK45689.1 - 1.1e-08 35.0 0.6 0.0013 18.5 0.0 3.0 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK45689.1 - 7.2e-07 29.5 0.1 0.0033 17.6 0.0 3.5 4 0 0 4 4 4 2 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK45689.1 - 0.0025 17.8 0.1 0.12 12.3 0.0 2.4 2 0 0 2 2 2 1 Tyrosine phosphatase family DUF5385 PF17359.2 PIK45689.1 - 0.0031 17.1 4.0 0.0036 16.9 1.0 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5385) DUF5305 PF17231.2 PIK45689.1 - 0.005 16.3 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF4448 PF14610.6 PIK45689.1 - 0.014 15.2 0.0 0.045 13.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF3377 PF11857.8 PIK45689.1 - 0.02 14.8 0.0 0.057 13.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CD34_antigen PF06365.12 PIK45689.1 - 0.032 13.8 0.0 0.082 12.5 0.0 1.6 1 0 0 1 1 1 0 CD34/Podocalyxin family Methyltransf_PK PF05891.12 PIK45689.1 - 0.037 13.5 0.0 7.1 6.1 0.0 2.3 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase DUF5383 PF17355.2 PIK45689.1 - 0.038 14.4 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5383) TMEM154 PF15102.6 PIK45689.1 - 0.04 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 PIK45689.1 - 0.046 14.6 0.0 0.21 12.5 0.0 2.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Insulin_TMD PF17870.1 PIK45689.1 - 0.062 13.4 1.3 0.13 12.3 1.3 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Orf78 PF06024.12 PIK45689.1 - 0.065 13.5 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 Orf78 (ac78) LapA_dom PF06305.11 PIK45689.1 - 0.089 12.6 0.3 0.23 11.3 0.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PAC4 PF16093.5 PIK45690.1 - 4.1e-12 46.1 0.0 5.2e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 DUF1296 PF06972.11 PIK45690.1 - 0.12 12.5 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Patched PF02460.18 PIK45691.1 - 2.6e-70 237.5 23.8 7.6e-45 153.3 0.8 3.0 2 1 1 3 3 3 2 Patched family NPC1_N PF16414.5 PIK45691.1 - 4.3e-61 206.6 6.1 6.2e-61 206.0 6.1 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 PIK45691.1 - 6.2e-53 178.8 2.8 6.2e-53 178.8 2.8 3.5 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK45691.1 - 9.5e-07 28.0 4.4 9.5e-07 28.0 4.4 3.1 3 0 0 3 3 3 1 MMPL family SecE PF00584.20 PIK45691.1 - 0.41 10.6 0.0 0.41 10.6 0.0 3.4 3 0 0 3 3 3 0 SecE/Sec61-gamma subunits of protein translocation complex ACR_tran PF00873.19 PIK45691.1 - 9 3.8 15.9 0.077 10.6 7.2 1.7 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Sulfotransfer_3 PF13469.6 PIK45692.1 - 0.012 16.0 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family zf-C2H2 PF00096.26 PIK45693.1 - 1.8e-11 43.8 5.5 2.1e-07 31.0 1.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK45693.1 - 8.5e-10 38.6 4.8 4e-05 24.1 0.7 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK45693.1 - 6.5e-09 35.6 2.3 4.1e-05 23.4 1.4 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK45693.1 - 3.8e-07 30.2 0.5 0.0073 16.6 0.1 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK45693.1 - 3.3e-06 26.8 2.2 0.0064 16.2 0.8 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 PIK45693.1 - 1.8e-05 24.9 8.0 0.0022 18.3 0.8 2.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 PIK45693.1 - 0.0016 18.8 2.7 1.1 9.7 0.1 2.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK45693.1 - 0.0029 17.7 3.6 0.007 16.5 3.6 1.6 1 1 0 1 1 1 1 Zinc ribbon domain Spt46 PF17734.1 PIK45693.1 - 0.014 15.3 2.7 0.21 11.3 0.2 2.0 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 zf-Di19 PF05605.12 PIK45693.1 - 0.018 15.3 3.0 0.19 12.0 3.0 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 PIK45693.1 - 0.02 15.6 0.7 0.024 15.4 0.7 1.3 1 0 0 1 1 1 0 zinc-ribbon family zf_UBZ PF18439.1 PIK45693.1 - 0.025 14.2 0.8 0.77 9.4 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 PIK45693.1 - 0.028 14.4 0.2 0.035 14.1 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 PIK45693.1 - 0.051 13.6 3.1 0.24 11.4 0.2 2.2 1 1 1 2 2 2 0 CpXC protein zinc_ribbon_2 PF13240.6 PIK45693.1 - 0.085 12.6 3.0 5.1 6.9 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF35_N PF12172.8 PIK45693.1 - 0.13 12.2 1.3 5.1 7.1 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-C2HE PF16278.5 PIK45693.1 - 0.14 12.7 2.2 4.5 7.8 0.1 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Mut7-C PF01927.16 PIK45693.1 - 0.16 12.1 1.9 0.56 10.3 2.0 1.8 1 1 0 1 1 1 0 Mut7-C RNAse domain zinc_ribbon_4 PF13717.6 PIK45693.1 - 0.25 11.3 3.7 5.9 6.9 0.3 2.4 1 1 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 PIK45693.1 - 0.34 11.0 4.2 1.3 9.2 4.2 1.9 1 1 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS91 PF14319.6 PIK45693.1 - 0.7 10.0 5.9 16 5.6 5.9 2.2 1 1 0 1 1 1 0 Transposase zinc-binding domain zf-C2H2_3 PF13878.6 PIK45693.1 - 0.94 9.4 9.5 6.2 6.7 4.0 2.6 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-H2C2_5 PF13909.6 PIK45693.1 - 1.2 8.9 10.7 3.2 7.6 0.4 2.9 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-BED PF02892.15 PIK45693.1 - 1.6 8.8 9.3 2 8.5 1.1 2.5 2 1 1 3 3 3 0 BED zinc finger zf-Mss51 PF13824.6 PIK45693.1 - 2.7 8.1 6.8 0.48 10.6 0.8 2.1 1 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Zn_Tnp_IS1595 PF12760.7 PIK45693.1 - 4.9 7.2 7.4 8.6 6.4 1.6 2.2 1 1 0 2 2 2 0 Transposase zinc-ribbon domain Nefa_Nip30_N PF10187.9 PIK45695.1 - 1.5e-27 96.0 20.5 1.5e-27 96.0 20.5 1.9 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 CemA PF03040.14 PIK45695.1 - 0.53 10.2 2.6 0.8 9.6 2.6 1.2 1 0 0 1 1 1 0 CemA family Voltage_CLC PF00654.20 PIK45697.1 - 1.2e-81 274.7 15.1 4.5e-46 157.7 1.9 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 PIK45697.1 - 2.6e-10 40.6 0.0 0.0002 21.8 0.0 2.6 2 0 0 2 2 2 2 CBS domain TAT_signal PF10518.9 PIK45697.1 - 0.82 9.6 6.9 0.1 12.5 2.1 2.0 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Ets PF00178.22 PIK45698.1 - 6.1e-31 106.7 1.6 1.1e-30 105.9 1.6 1.4 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 PIK45698.1 - 1.8e-19 69.5 0.5 4.1e-19 68.3 0.0 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SUIM_assoc PF16619.5 PIK45698.1 - 0.0081 16.2 1.9 0.028 14.5 1.9 2.2 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 HMG_box PF00505.19 PIK45699.1 - 2.3e-24 85.6 6.1 5.6e-24 84.3 6.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK45699.1 - 3.1e-11 43.7 1.8 3.1e-11 43.7 1.8 1.8 2 0 0 2 2 2 1 HMG-box domain DUF3915 PF13054.6 PIK45701.1 - 0.053 13.5 4.5 0.16 11.9 4.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Activator_LAG-3 PF11498.8 PIK45701.1 - 1.1 8.2 23.7 1.5 7.7 23.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FAM76 PF16046.5 PIK45701.1 - 1.2 8.4 10.7 1.5 8.1 10.7 1.2 1 0 0 1 1 1 0 FAM76 protein DUF3347 PF11827.8 PIK45701.1 - 2.6 8.2 10.1 0.63 10.2 7.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) Atrophin-1 PF03154.15 PIK45701.1 - 7.4 4.7 21.6 0.025 12.9 11.7 1.7 2 0 0 2 2 2 0 Atrophin-1 family Got1 PF04178.12 PIK45702.1 - 5.4e-19 68.7 14.3 6.7e-19 68.4 14.3 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF202 PF02656.15 PIK45702.1 - 1.2 9.7 7.4 2.1 8.8 3.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) API5 PF05918.11 PIK45703.1 - 1.8e-110 370.2 3.4 1.8e-110 370.2 3.4 1.8 1 1 1 2 2 2 1 Apoptosis inhibitory protein 5 (API5) Adaptin_N PF01602.20 PIK45703.1 - 0.0011 17.7 0.4 0.0018 16.9 0.4 1.5 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 PIK45703.1 - 0.0013 19.0 0.3 0.035 14.5 0.2 2.6 2 1 1 3 3 3 2 HEAT repeats MMS19_N PF14500.6 PIK45703.1 - 0.0027 17.3 0.7 0.2 11.2 0.1 2.4 1 1 1 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II V_ATPase_I PF01496.19 PIK45703.1 - 0.013 13.4 0.9 0.017 13.1 0.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnd1 PF12717.7 PIK45703.1 - 0.053 13.6 1.2 1.7 8.7 0.8 2.7 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Telomere_reg-2 PF10193.9 PIK45703.1 - 0.099 13.1 0.2 0.61 10.5 0.1 2.3 2 1 0 2 2 2 0 Telomere length regulation protein RR_TM4-6 PF06459.12 PIK45703.1 - 1.9 8.3 9.6 3 7.6 9.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 API5 PF05918.11 PIK45704.1 - 3.4e-38 131.8 2.0 4.5e-38 131.4 2.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Dak2 PF02734.17 PIK45705.1 - 0.097 12.6 4.2 29 4.5 0.1 4.0 4 0 0 4 4 4 0 DAK2 domain YccF PF03733.13 PIK45706.1 - 5.6e-11 43.0 19.9 1.3e-10 41.8 5.2 2.5 2 0 0 2 2 2 2 Inner membrane component domain Na_Ca_ex PF01699.24 PIK45707.1 - 0.0031 17.5 4.9 0.0031 17.5 4.9 1.0 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DNA_pol_B PF00136.21 PIK45708.1 - 3.7e-148 494.0 0.1 5.7e-148 493.4 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 PIK45708.1 - 7.5e-67 225.8 0.1 1.2e-66 225.2 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 PIK45708.1 - 1.7e-08 34.8 7.6 3.8e-08 33.7 7.6 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 PIK45708.1 - 1.8e-05 23.8 1.6 0.00018 20.6 0.2 2.2 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 PIK45708.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zf-C4H2 PF10146.9 PIK45708.1 - 0.28 11.5 0.0 0.28 11.5 0.0 1.9 2 0 0 2 2 1 0 Zinc finger-containing protein OrfB_Zn_ribbon PF07282.11 PIK45708.1 - 0.31 11.0 3.1 54 3.8 0.0 3.2 3 1 0 3 3 3 0 Putative transposase DNA-binding domain DZR PF12773.7 PIK45708.1 - 0.99 9.5 6.5 3.5 7.7 6.4 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-CXXC PF02008.20 PIK45708.1 - 3.5 7.7 6.3 2.3 8.3 1.3 2.5 2 0 0 2 2 2 0 CXXC zinc finger domain Prok-RING_1 PF14446.6 PIK45708.1 - 5.4 7.0 9.2 0.35 10.8 1.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-ACC PF17848.1 PIK45708.1 - 5.8 7.1 9.4 2.5 8.2 0.2 3.4 2 1 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Sugar_tr PF00083.24 PIK45709.1 - 4.7e-32 111.4 17.1 6.4e-32 111.0 17.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK45709.1 - 4.8e-22 78.4 23.7 6.9e-22 77.8 23.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Popeye PF04831.13 PIK45710.1 - 2.8e-33 115.1 0.3 3.4e-33 114.8 0.3 1.1 1 0 0 1 1 1 1 Popeye protein conserved region Popeye PF04831.13 PIK45711.1 - 5e-32 111.0 3.6 5.9e-32 110.7 3.6 1.1 1 0 0 1 1 1 1 Popeye protein conserved region LANC_like PF05147.13 PIK45712.1 - 8.1e-70 235.1 0.2 6e-69 232.3 0.1 1.6 1 1 1 2 2 2 2 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.12 PIK45712.1 - 0.11 11.0 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 Pkinase_Tyr PF07714.17 PIK45713.1 - 3.2e-30 105.3 0.0 4e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45713.1 - 1.3e-08 34.6 0.0 1.7e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Neur_chan_LBD PF02931.23 PIK45714.1 - 4.7e-53 179.8 0.1 7.8e-53 179.1 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK45714.1 - 4.2e-31 108.8 1.6 5.8e-31 108.4 1.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_L24e PF01246.20 PIK45715.1 - 6.2e-30 103.2 1.9 6.2e-30 103.2 1.9 2.3 2 1 0 2 2 2 1 Ribosomal protein L24e DUF2785 PF10978.8 PIK45715.1 - 0.008 16.0 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2785) Band_3_cyto PF07565.13 PIK45715.1 - 0.87 9.3 7.8 1.1 9.0 7.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DDHD PF02862.17 PIK45715.1 - 2.3 8.3 6.5 2.9 8.0 6.5 1.1 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 PIK45715.1 - 3.9 7.2 11.4 4.9 6.9 11.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 PIK45715.1 - 9.9 6.1 6.7 12 5.8 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DoxX_2 PF13564.6 PIK45716.1 - 6.5e-06 26.2 9.2 2e-05 24.6 9.2 1.7 1 1 0 1 1 1 1 DoxX-like family PAC1 PF16094.5 PIK45717.1 - 3.4e-57 193.8 1.0 1.5e-56 191.7 1.0 1.8 1 1 0 1 1 1 1 Proteasome assembly chaperone 4 PAC2 PF09754.9 PIK45717.1 - 0.0023 18.0 0.0 0.0029 17.6 0.0 1.2 1 0 0 1 1 1 1 PAC2 family Dynein_C PF18199.1 PIK45718.1 - 2.7e-99 332.3 5.4 6.3e-99 331.1 0.0 3.1 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 PIK45718.1 - 6.8e-86 286.9 2.5 6.8e-86 286.9 2.5 3.3 4 0 0 4 4 4 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK45718.1 - 1.3e-56 191.0 0.1 2.2e-56 190.2 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 PIK45718.1 - 1.2e-45 156.1 6.4 1.2e-45 156.1 6.4 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 PIK45718.1 - 1.1e-43 148.1 0.6 7.8e-43 145.4 0.0 2.7 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MIX PF18529.1 PIK45718.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial membrane-anchored proteins UPF0242 PF06785.11 PIK45718.1 - 0.34 11.0 14.4 0.71 9.9 0.1 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Borrelia_P83 PF05262.11 PIK45718.1 - 4 5.8 17.7 3.4 6.1 7.3 2.4 2 0 0 2 2 2 0 Borrelia P83/100 protein DUF4407 PF14362.6 PIK45718.1 - 7.4 5.8 17.0 2.1 7.6 1.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) AAA_6 PF12774.7 PIK45719.1 - 7.4e-147 488.6 0.0 1e-145 484.8 0.0 2.5 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK45719.1 - 4e-125 418.0 4.0 4e-125 418.0 4.0 2.3 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK45719.1 - 1.3e-83 280.3 0.0 3.4e-83 279.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 PIK45719.1 - 3.5e-69 231.9 3.1 8.2e-64 214.4 0.2 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 PIK45719.1 - 2.1e-24 86.1 0.8 7.8e-22 77.7 0.1 3.4 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK45719.1 - 1e-22 80.6 0.0 2.7e-07 30.7 0.0 5.2 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 PIK45719.1 - 3.3e-14 52.9 0.0 1.5e-13 50.8 0.0 2.2 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 PIK45719.1 - 2.3e-07 31.3 0.2 0.3 11.5 0.0 4.4 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK45719.1 - 1.7e-05 25.3 0.1 4.7 7.6 0.0 5.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 PIK45719.1 - 9.5e-05 22.7 1.2 6.5 7.0 0.0 4.8 5 0 0 5 5 4 1 AAA domain AAA_18 PF13238.6 PIK45719.1 - 0.013 16.0 0.5 6.6 7.3 0.0 4.1 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.6 PIK45719.1 - 0.052 13.3 3.1 55 3.6 0.0 4.2 4 0 0 4 4 4 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 PIK45719.1 - 0.083 13.3 0.9 18 5.8 0.0 3.4 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 PIK45719.1 - 0.11 12.2 5.6 34 4.1 0.0 3.9 4 0 0 4 4 4 0 AAA domain DUF815 PF05673.13 PIK45719.1 - 0.12 11.5 0.1 10 5.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 PIK45719.1 - 0.15 11.7 1.6 9.8 5.8 0.0 3.5 4 0 0 4 4 4 0 Sigma-54 interaction domain AAA_19 PF13245.6 PIK45719.1 - 0.26 11.6 3.4 62 3.9 0.0 3.8 3 0 0 3 3 3 0 AAA domain Csm2_III-A PF03750.13 PIK45719.1 - 0.49 11.2 1.8 1.1 10.2 0.1 2.5 2 0 0 2 2 1 0 Csm2 Type III-A ABC_tran PF00005.27 PIK45719.1 - 0.7 10.4 3.4 12 6.4 0.0 4.1 5 0 0 5 5 4 0 ABC transporter AAA_33 PF13671.6 PIK45719.1 - 1.1 9.4 2.8 47 4.1 0.0 3.6 4 0 0 4 4 3 0 AAA domain DHC_N1 PF08385.12 PIK45720.1 - 8.2e-186 619.0 5.2 1.1e-185 618.5 5.2 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 GIDA_assoc PF13932.6 PIK45720.1 - 0.076 13.2 0.1 0.076 13.2 0.1 2.4 3 0 0 3 3 3 0 GidA associated domain Elf4 PF07011.11 PIK45720.1 - 0.14 12.1 1.2 5.4 7.0 0.0 3.3 3 0 0 3 3 3 0 Early Flowering 4 domain Imm3 PF14425.6 PIK45720.1 - 0.18 11.9 2.2 15 5.7 0.1 3.9 3 1 0 3 3 3 0 Immunity protein Imm3 MBT PF02820.18 PIK45721.1 - 1.3e-49 166.4 0.0 7.5e-27 93.5 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.8 PIK45721.1 - 6.4e-27 94.3 0.1 1e-26 93.6 0.1 1.3 1 0 0 1 1 1 1 SLED domain gpW PF02831.15 PIK45721.1 - 0.031 14.2 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 gpW S-methyl_trans PF02574.16 PIK45722.1 - 1e-16 61.6 0.2 1.4e-16 61.1 0.2 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase ADH_zinc_N PF00107.26 PIK45722.1 - 0.099 12.6 0.1 1.2 9.1 0.1 2.1 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Glyco_transf_10 PF00852.19 PIK45723.1 - 3.6e-44 150.6 0.6 4.5e-44 150.3 0.6 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term AMP-binding PF00501.28 PIK45724.1 - 2.4e-37 128.6 0.1 2.3e-27 95.6 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 PIK45724.1 - 8.3e-09 36.3 0.0 1.5e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK45725.1 - 4.6e-49 167.2 0.0 5.9e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK45725.1 - 1.6e-09 38.6 0.0 4.2e-09 37.2 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain C2 PF00168.30 PIK45727.1 - 1.5e-29 102.3 0.0 1.1e-21 77.1 0.0 2.2 2 0 0 2 2 2 2 C2 domain GAD PF02938.14 PIK45727.1 - 0.074 13.3 0.0 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 GAD domain SoxZ PF08770.11 PIK45727.1 - 0.094 12.5 0.0 6.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Sulphur oxidation protein SoxZ C2 PF00168.30 PIK45728.1 - 2.2e-22 79.3 0.0 5.4e-22 78.0 0.0 1.6 2 0 0 2 2 2 1 C2 domain Caudo_bapla_RBP PF08931.10 PIK45728.1 - 0.066 12.7 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head PRT_C PF08372.10 PIK45729.1 - 0.0083 15.9 0.4 0.01 15.6 0.4 1.1 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal BatA PF07584.11 PIK45729.1 - 0.87 10.0 8.3 6 7.3 3.8 2.2 1 1 1 2 2 2 0 Aerotolerance regulator N-terminal Ribosomal_L36e PF01158.18 PIK45730.1 - 9.4e-36 121.9 8.3 1.1e-35 121.7 8.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e RQC PF09382.10 PIK45732.1 - 1.2e-19 70.2 0.0 2.4e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 PIK45732.1 - 2.1e-17 63.6 3.4 7.7e-17 61.8 3.4 2.1 1 0 0 1 1 1 1 RecQ zinc-binding DEAD PF00270.29 PIK45732.1 - 2.6e-17 63.1 0.0 4.8e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.23 PIK45732.1 - 6.5e-16 58.1 0.0 1.4e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Helicase_C PF00271.31 PIK45732.1 - 1.8e-14 54.0 0.0 1.1e-13 51.5 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK45732.1 - 0.0058 16.7 0.0 0.016 15.2 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_Sgs1 PF11408.8 PIK45732.1 - 0.08 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase RNA_pol_Rpc4 PF05132.14 PIK45732.1 - 0.084 13.3 4.6 0.16 12.4 4.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Pkinase_Tyr PF07714.17 PIK45733.1 - 3.3e-92 308.4 0.0 4.5e-92 308.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45733.1 - 8.1e-42 143.4 0.0 1.2e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK45733.1 - 2.2e-14 53.6 3.3 0.00012 22.3 0.1 4.6 4 0 0 4 4 4 3 Fibronectin type III domain Recep_L_domain PF01030.24 PIK45733.1 - 5.9e-12 45.7 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Receptor L domain Kinase-like PF14531.6 PIK45733.1 - 0.0043 16.4 0.0 0.0097 15.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK45733.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Furin-like PF00757.20 PIK45734.1 - 7.7e-22 77.8 34.9 9.2e-22 77.5 34.9 1.1 1 0 0 1 1 1 1 Furin-like cysteine rich region GF_recep_IV PF14843.6 PIK45734.1 - 0.00087 19.1 32.4 0.0019 18.0 18.5 2.5 1 1 1 2 2 2 2 Growth factor receptor domain IV TIL PF01826.17 PIK45734.1 - 0.59 10.4 39.3 1.3 9.3 2.2 4.0 2 2 1 3 3 3 0 Trypsin Inhibitor like cysteine rich domain Arfaptin PF06456.13 PIK45735.1 - 3.3e-71 239.5 2.6 5.6e-71 238.7 2.6 1.4 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 PIK45735.1 - 4.1e-11 43.1 0.0 7.3e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK45735.1 - 2e-09 37.1 0.0 4.4e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK45735.1 - 3.6e-08 33.6 0.0 7.7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF2202 PF09968.9 PIK45735.1 - 0.0025 17.7 0.3 0.0046 16.8 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized protein domain (DUF2202) LMBR1 PF04791.16 PIK45735.1 - 0.15 10.9 0.1 0.22 10.4 0.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Ras PF00071.22 PIK45736.1 - 8.6e-10 38.4 0.0 1e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 PIK45736.1 - 0.039 13.5 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF89 PF01937.19 PIK45736.1 - 0.078 11.9 0.0 0.082 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF89 Ras PF00071.22 PIK45738.1 - 1.4e-16 60.5 0.0 1.7e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK45738.1 - 2.4e-10 40.6 0.0 3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK45738.1 - 0.0042 16.5 0.0 0.005 16.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 PIK45738.1 - 0.014 14.9 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK45738.1 - 0.026 14.6 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 PIK45738.1 - 0.03 13.9 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 PIK45738.1 - 0.034 13.6 0.0 0.042 13.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein S19 PF06756.11 PIK45740.1 - 0.064 13.2 0.3 0.27 11.2 0.1 2.0 1 1 1 2 2 2 0 Chorion protein S19 C-terminal SMYLE_N PF18615.1 PIK45741.1 - 7.3 6.0 9.1 7.8 5.9 8.2 1.3 1 1 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain ETF PF01012.21 PIK45742.1 - 1e-35 123.3 0.1 1.2e-35 123.1 0.1 1.0 1 0 0 1 1 1 1 Electron transfer flavoprotein domain DUF2103 PF09876.9 PIK45742.1 - 0.14 12.2 0.0 0.36 10.8 0.0 1.7 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2103) ETF_alpha PF00766.19 PIK45743.1 - 1.1e-37 127.9 0.2 1.6e-37 127.4 0.2 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain PP28 PF10252.9 PIK45744.1 - 1.1e-25 89.8 20.4 1.1e-25 89.8 20.4 2.3 2 0 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 Dehydrin PF00257.19 PIK45744.1 - 2.4 8.7 13.4 4.3 7.9 13.3 1.7 1 1 0 1 1 1 0 Dehydrin MFS_1 PF07690.16 PIK45745.1 - 9.3e-31 107.0 28.1 9.3e-31 107.0 28.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK45745.1 - 2.7e-29 102.3 18.2 3.9e-29 101.8 18.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 PIK45745.1 - 0.00052 18.7 6.0 0.00052 18.7 6.0 2.8 3 0 0 3 3 3 1 MFS/sugar transport protein SH2 PF00017.24 PIK45747.1 - 1.2e-16 60.6 0.0 1.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 PIK45748.1 - 8.4e-36 123.6 0.1 1.2e-35 123.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK45748.1 - 8.8e-17 61.3 0.0 1.2e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain B2 PF11473.8 PIK45748.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA binding protein B2 RT_RNaseH PF17917.1 PIK45755.1 - 1.3e-36 125.0 0.0 2e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK45755.1 - 2.6e-33 114.0 0.0 4e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK45756.1 - 6.5e-17 61.8 0.0 1.8e-16 60.4 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK45756.1 - 7.7e-17 61.1 2.4 1.5e-16 60.2 2.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK45756.1 - 0.00032 20.9 0.4 0.00064 19.9 0.4 1.5 1 0 0 1 1 1 1 H2C2 zinc finger MULE PF10551.9 PIK45758.1 - 1.9e-06 28.2 0.0 3.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain SsgA PF04686.12 PIK45758.1 - 0.086 12.8 0.2 0.43 10.6 0.0 2.2 3 0 0 3 3 3 0 Streptomyces sporulation and cell division protein, SsgA RVT_1 PF00078.27 PIK45759.1 - 1.5e-05 24.6 0.1 4.6e-05 23.0 0.0 2.0 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L40e PF01020.17 PIK45759.1 - 0.073 13.0 0.2 0.23 11.3 0.2 1.9 1 1 0 1 1 1 0 Ribosomal L40e family Helitron_like_N PF14214.6 PIK45760.1 - 8.5e-16 58.7 0.2 5.6e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus RVT_1 PF00078.27 PIK45760.1 - 0.036 13.6 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 PIK45761.1 - 1.8e-12 47.2 0.2 2e-12 47.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45761.1 - 3.3e-08 33.1 0.1 3.8e-08 32.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L27A PF00828.19 PIK45761.1 - 0.071 13.8 0.2 0.085 13.5 0.2 1.1 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Lectin_C PF00059.21 PIK45762.1 - 1.3e-06 29.1 0.6 5.3e-06 27.1 0.1 2.0 1 1 1 2 2 2 1 Lectin C-type domain UL45 PF05473.12 PIK45762.1 - 0.0044 16.7 0.3 0.0084 15.8 0.1 1.6 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like IQ PF00612.27 PIK45763.1 - 7.7e-29 96.8 16.4 4.4e-05 22.9 0.1 6.2 6 0 0 6 6 6 6 IQ calmodulin-binding motif Yop-YscD_cpl PF16697.5 PIK45763.1 - 4.2e-05 23.8 1.0 6.6 7.1 0.0 4.3 4 0 0 4 4 4 3 Inner membrane component of T3SS, cytoplasmic domain WD40 PF00400.32 PIK45764.1 - 1.6e-12 47.7 19.4 0.0002 22.1 1.0 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat TPR_1 PF00515.28 PIK45765.1 - 1.3e-17 62.8 0.4 3.5e-08 32.9 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45765.1 - 7.7e-15 53.7 0.6 7.4e-06 25.7 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK45765.1 - 5.7e-11 42.8 7.4 2.1e-05 24.9 0.3 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45765.1 - 7.9e-09 35.0 2.3 0.00024 21.1 0.0 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK45765.1 - 7.6e-08 32.6 0.1 0.3 12.0 0.0 4.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45765.1 - 3.4e-06 26.6 1.4 0.15 11.8 0.1 3.6 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.6 PIK45765.1 - 3.8e-06 27.4 0.8 0.0022 18.6 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK45765.1 - 1.9e-05 24.4 0.9 0.24 11.5 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK45765.1 - 2.8e-05 24.3 6.6 0.034 14.4 2.2 4.2 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK45765.1 - 4.3e-05 23.7 4.2 0.00037 20.7 1.8 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 PIK45765.1 - 0.00039 20.1 0.1 0.0017 18.0 0.1 2.1 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_17 PF13431.6 PIK45765.1 - 0.00045 20.4 0.6 0.68 10.4 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK45765.1 - 0.0046 17.5 2.9 1 10.1 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat MIT PF04212.18 PIK45765.1 - 0.019 15.0 9.3 0.042 13.9 0.2 4.4 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 PIK45765.1 - 0.029 14.5 0.0 0.091 12.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat HemY_N PF07219.13 PIK45765.1 - 0.049 13.8 0.5 0.14 12.4 0.5 1.7 1 0 0 1 1 1 0 HemY protein N-terminus Egg_lysin PF01303.17 PIK45765.1 - 0.11 12.7 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) TPR_10 PF13374.6 PIK45765.1 - 0.11 12.4 2.6 0.69 9.9 0.5 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2672 PF10878.8 PIK45765.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2672) NTP_transferase PF00483.23 PIK45766.1 - 8.7e-12 45.1 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 PIK45766.1 - 1e-05 26.0 0.0 1.2e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain EVE PF01878.18 PIK45766.1 - 0.052 13.6 0.1 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 EVE domain CT_C_D PF02682.16 PIK45766.1 - 0.06 13.1 0.0 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D GHMP_kinases_N PF00288.26 PIK45767.1 - 1.5e-07 31.6 0.0 2.9e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 PIK45767.1 - 3.2e-07 30.6 0.1 7.2e-07 29.5 0.0 1.6 2 0 0 2 2 2 1 GHMP kinases C terminal BTG PF07742.12 PIK45768.1 - 9.6e-40 135.1 0.0 1.5e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 BTG family LRR_8 PF13855.6 PIK45769.1 - 1.7e-32 111.0 32.9 2.9e-10 39.7 1.6 5.3 2 1 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK45769.1 - 3.5e-16 59.3 14.6 3.1e-06 27.2 0.9 3.2 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK45769.1 - 1.8e-12 47.3 34.7 0.00021 21.6 2.5 6.2 3 1 5 8 8 8 7 Leucine Rich repeats (2 copies) LRRNT PF01462.18 PIK45769.1 - 2.1e-06 27.2 3.8 8.4e-06 25.3 3.8 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK45769.1 - 2.7e-06 27.1 23.2 0.17 12.6 0.2 7.6 7 0 0 7 7 7 3 Leucine Rich Repeat BRICHOS PF04089.14 PIK45769.1 - 0.0025 18.0 0.4 0.2 11.9 0.1 2.5 2 0 0 2 2 2 1 BRICHOS domain Toxin_11 PF07473.11 PIK45769.1 - 0.015 15.3 1.7 0.075 13.1 1.7 2.2 1 0 0 1 1 1 0 Spasmodic peptide gm9a; conotoxin from Conus species LRR_9 PF14580.6 PIK45769.1 - 0.038 13.5 13.1 1.1 8.7 3.2 2.7 1 1 1 2 2 2 0 Leucine-rich repeat Cadherin_C_2 PF16492.5 PIK45769.1 - 0.097 13.4 1.2 0.29 11.9 1.2 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal SRCR PF00530.18 PIK45770.1 - 2.4e-137 448.4 33.3 2.9e-29 101.5 3.1 6.0 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK45770.1 - 1.2e-27 96.3 15.1 3.3e-05 24.3 0.1 6.4 6 0 0 6 6 6 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK45770.1 - 8.8e-13 48.7 0.5 0.47 11.0 0.0 5.5 5 0 0 5 5 5 4 Hepsin, SRCR domain YecR PF13992.6 PIK45770.1 - 0.0032 17.7 9.2 1.6 9.1 0.1 4.8 4 0 0 4 4 4 2 YecR-like lipoprotein CreA PF05981.12 PIK45770.1 - 0.18 11.8 0.2 20 5.2 0.0 3.6 4 0 0 4 4 4 0 CreA protein DUF2961 PF11175.8 PIK45770.1 - 3.4 7.2 12.5 13 5.4 0.1 5.0 4 3 1 6 6 6 0 Protein of unknown function (DUF2961) Cu-oxidase_3 PF07732.15 PIK45771.1 - 3.7e-40 136.7 1.3 1.2e-37 128.6 0.1 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 PIK45771.1 - 2.8e-20 73.1 0.2 8.2e-20 71.5 0.1 1.8 2 0 0 2 2 2 1 Multicopper oxidase SRCR PF00530.18 PIK45771.1 - 1.4e-16 60.8 0.0 2.4e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Cu-oxidase_2 PF07731.14 PIK45771.1 - 4.1e-07 29.8 1.0 1.1e-05 25.2 0.4 2.9 2 1 0 2 2 2 1 Multicopper oxidase SRCR_2 PF15494.6 PIK45771.1 - 0.013 16.0 0.1 0.027 15.0 0.1 1.5 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain HYR PF02494.16 PIK45773.1 - 2.8e-15 56.4 1.1 7.6e-15 55.0 1.1 1.8 1 0 0 1 1 1 1 HYR domain CUB PF00431.20 PIK45773.1 - 1.6e-06 28.4 0.0 3.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 CUB domain EGF PF00008.27 PIK45773.1 - 0.00062 20.0 7.2 0.0014 18.9 7.2 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK45773.1 - 0.0068 17.0 3.6 0.0068 17.0 3.6 2.6 2 0 0 2 2 2 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK45773.1 - 1.2 9.6 12.2 2.4 8.6 12.2 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_CA PF07645.15 PIK45773.1 - 1.3 9.3 8.2 3.2 8.1 8.2 1.6 1 0 0 1 1 1 0 Calcium-binding EGF domain HYR PF02494.16 PIK45774.1 - 1.5e-12 47.6 16.5 2.3e-12 47.0 5.2 2.2 2 0 0 2 2 2 2 HYR domain DUF723 PF05265.13 PIK45774.1 - 1.4 8.9 6.8 1.1 9.2 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF723) EGF_3 PF12947.7 PIK45774.1 - 1.4 9.1 9.9 1.9 8.7 1.2 3.0 2 1 0 2 2 2 0 EGF domain HYR PF02494.16 PIK45775.1 - 1.9e-12 47.3 13.2 4.2e-12 46.2 4.9 2.1 2 0 0 2 2 2 2 HYR domain Ustilago_mating PF05722.12 PIK45775.1 - 0.032 13.8 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein GBP_PSP PF02425.15 PIK45777.1 - 0.11 12.2 0.1 1.7 8.3 0.2 2.3 2 0 0 2 2 2 0 Paralytic/GBP/PSP peptide LRRC37AB_C PF14914.6 PIK45777.1 - 0.44 10.5 2.1 14 5.5 0.6 2.2 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain BAR PF03114.18 PIK45778.1 - 9.2e-15 54.9 1.0 9.8e-15 54.8 1.0 1.0 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 PIK45778.1 - 0.012 15.3 0.9 0.013 15.2 0.9 1.0 1 0 0 1 1 1 0 BAR domain of APPL family Amino_oxidase PF01593.24 PIK45779.1 - 2.1e-14 53.7 0.0 2.4e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK45779.1 - 2.5e-13 50.0 0.0 4e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK45779.1 - 1.3e-07 31.1 0.0 2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 PIK45779.1 - 1.3e-06 28.2 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 PIK45779.1 - 5.7e-06 25.6 0.0 7.6e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 PIK45779.1 - 1.5e-05 24.3 0.0 1.8e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK45779.1 - 6.7e-05 22.3 0.0 8.3e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK45779.1 - 0.00019 21.5 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 PIK45779.1 - 0.0013 17.5 0.3 0.0023 16.7 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 PIK45779.1 - 0.0036 16.7 0.0 0.0043 16.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK45779.1 - 0.0044 17.6 0.1 0.0086 16.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MtrD PF04207.12 PIK45779.1 - 0.024 14.3 0.0 0.03 14.0 0.0 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D FAD_binding_3 PF01494.19 PIK45779.1 - 0.029 13.6 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 PIK45779.1 - 0.044 12.9 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 PIK45779.1 - 0.11 11.6 0.2 0.18 10.9 0.1 1.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 PIK45780.1 - 2e-11 43.9 0.0 2.2e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NitrOD2 PF18550.1 PIK45780.1 - 0.049 13.8 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Nitrososphaera output domain 2 DUF4366 PF14283.6 PIK45780.1 - 0.078 13.0 0.4 0.11 12.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CAP PF00188.26 PIK45781.1 - 2.2e-53 180.4 8.7 9.3e-20 71.7 0.4 3.2 3 0 0 3 3 3 3 Cysteine-rich secretory protein family Cytochrom_D1 PF02239.16 PIK45781.1 - 0.0023 16.5 0.0 0.34 9.4 0.0 2.9 3 0 0 3 3 3 2 Cytochrome D1 heme domain DUF4942 PF13708.6 PIK45781.1 - 0.11 12.5 6.5 0.24 11.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4942) DNase_II PF03265.15 PIK45782.1 - 3.7e-95 318.9 7.9 4.5e-95 318.6 7.9 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Wza_C PF18412.1 PIK45782.1 - 0.47 10.2 1.8 5.5 6.8 0.1 2.4 2 0 0 2 2 2 0 Outer-membrane lipoprotein Wza C-terminal domain Transferrin PF00405.17 PIK45783.1 - 3.8e-08 32.9 0.0 7.5e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Transferrin Cys_knot PF00007.22 PIK45783.1 - 0.0029 17.9 5.9 0.0059 16.9 5.9 1.5 1 0 0 1 1 1 1 Cystine-knot domain Pantoate_ligase PF02569.15 PIK45783.1 - 0.02 14.2 0.1 0.034 13.4 0.1 1.3 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Transferrin PF00405.17 PIK45784.1 - 1.8e-33 116.1 1.5 1e-20 74.2 0.6 2.1 2 0 0 2 2 2 2 Transferrin Mg296 PF09644.10 PIK45784.1 - 0.1 12.8 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Mg296 protein Transferrin PF00405.17 PIK45785.1 - 3.4e-43 148.1 0.4 9.9e-20 70.9 0.7 3.4 3 1 0 3 3 3 3 Transferrin WAP PF00095.21 PIK45785.1 - 7.2e-06 26.3 12.1 7.2e-06 26.3 12.1 2.6 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Phosphonate-bd PF12974.7 PIK45785.1 - 0.0025 17.4 0.0 0.0058 16.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Sushi PF00084.20 PIK45786.1 - 6.5e-09 36.2 4.0 1.1e-08 35.6 2.1 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK45786.1 - 0.0019 18.7 0.2 0.069 13.8 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK45786.1 - 0.022 15.1 0.9 0.11 12.8 0.0 2.4 1 1 2 3 3 3 0 Immunoglobulin domain Ig_4 PF16680.5 PIK45786.1 - 0.023 15.0 0.1 0.35 11.1 0.0 2.3 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain HRM PF02793.22 PIK45786.1 - 0.08 13.2 0.2 0.2 12.0 0.2 1.7 1 0 0 1 1 1 0 Hormone receptor domain ig PF00047.25 PIK45786.1 - 0.11 12.7 0.4 2.1 8.6 0.1 2.7 2 1 0 2 2 2 0 Immunoglobulin domain DUF3432 PF11914.8 PIK45788.1 - 0.079 13.2 0.6 0.58 10.4 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3432) PTEN_C2 PF10409.9 PIK45789.1 - 6e-31 107.0 1.5 8.4e-31 106.5 1.5 1.2 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 PIK45789.1 - 6.3e-06 26.0 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK45789.1 - 0.0015 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK45789.1 - 0.0033 17.4 0.0 0.0049 16.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK45789.1 - 0.0083 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Kelch_1 PF01344.25 PIK45790.1 - 1e-86 284.3 19.3 6.5e-16 57.6 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK45790.1 - 1.7e-44 148.7 2.4 1.8e-07 31.2 0.0 6.5 2 2 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 PIK45790.1 - 6.6e-30 101.9 5.4 1.1e-05 25.2 0.0 6.4 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 PIK45790.1 - 5.4e-29 100.3 6.2 8.5e-18 64.4 1.4 2.7 2 0 0 2 2 2 2 BTB And C-terminal Kelch Kelch_4 PF13418.6 PIK45790.1 - 6.8e-29 99.6 3.6 8.4e-05 22.5 0.0 6.3 4 1 2 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 PIK45790.1 - 3.2e-27 94.9 0.1 8e-27 93.7 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 PIK45790.1 - 2.6e-26 91.3 12.8 0.00012 22.2 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK45790.1 - 6.6e-05 22.8 15.0 0.5 10.4 0.2 5.4 5 0 0 5 5 5 3 Kelch motif PQQ_3 PF13570.6 PIK45790.1 - 0.0085 16.6 16.6 4.2 8.0 0.2 5.4 5 0 0 5 5 5 1 PQQ-like domain UQ_con PF00179.26 PIK45791.1 - 1.3e-37 128.5 0.0 1.5e-37 128.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK45791.1 - 0.0043 17.3 0.0 0.0043 17.3 0.0 1.1 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK45791.1 - 0.21 11.3 0.0 0.24 11.1 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B NACHT PF05729.12 PIK45792.1 - 3.1e-17 63.0 0.1 8.3e-17 61.6 0.1 1.8 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK45792.1 - 1.1e-06 28.8 4.0 1.1e-06 28.8 4.0 2.8 2 0 0 2 2 2 1 Death effector domain ABC_tran PF00005.27 PIK45792.1 - 0.0021 18.6 0.6 0.013 16.0 0.0 2.7 3 0 0 3 3 3 1 ABC transporter NB-ARC PF00931.22 PIK45792.1 - 0.012 14.8 0.1 0.012 14.8 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain DAP3 PF10236.9 PIK45792.1 - 0.024 13.8 4.2 0.26 10.4 0.1 3.5 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Arf PF00025.21 PIK45792.1 - 0.035 13.6 0.6 0.17 11.3 0.1 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family LRR_4 PF12799.7 PIK45792.1 - 0.048 14.1 25.3 0.33 11.4 0.1 6.2 6 1 0 6 6 5 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK45792.1 - 0.22 11.7 14.5 2.8 8.2 0.0 6.4 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 PIK45792.1 - 0.71 10.6 17.0 27 5.9 0.7 6.2 5 0 0 5 5 5 0 Leucine Rich Repeat DUF1843 PF08898.10 PIK45792.1 - 2.7 8.6 4.5 7.5 7.1 0.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) LRR_8 PF13855.6 PIK45792.1 - 7.8 6.4 17.8 2.9 7.7 1.3 5.1 5 1 0 5 5 5 0 Leucine rich repeat Ion_trans PF00520.31 PIK45793.1 - 9.9e-42 142.8 19.5 1.3e-41 142.4 19.5 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK45793.1 - 9.2e-06 24.6 15.5 0.00031 19.5 4.7 2.2 2 0 0 2 2 2 2 Polycystin cation channel DUF2976 PF11190.8 PIK45793.1 - 0.14 11.9 1.2 0.27 11.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) DUF4538 PF15061.6 PIK45793.1 - 0.22 11.3 1.4 0.63 9.8 1.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Solute_trans_a PF03619.16 PIK45793.1 - 2.3 7.7 10.1 1.3 8.5 1.0 2.6 2 1 1 3 3 3 0 Organic solute transporter Ostalpha Tet_JBP PF12851.7 PIK45794.1 - 4.3e-98 328.7 0.7 7.6e-98 327.9 0.7 1.4 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily GRAM PF02893.20 PIK45796.1 - 2.1e-09 37.2 0.0 1.3e-08 34.7 0.0 2.0 1 1 1 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.8 PIK45796.1 - 9.2e-05 22.6 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 PIK45796.1 - 0.039 14.3 0.0 0.063 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain DUF4205 PF13898.6 PIK45796.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) DUF2076 PF09849.9 PIK45796.1 - 3.3 7.7 10.6 4.3 7.3 10.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) HEAT PF02985.22 PIK45797.1 - 1.2e-10 40.7 16.1 0.84 10.1 0.0 9.9 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.6 PIK45797.1 - 5.1e-09 36.4 6.5 0.0016 18.8 0.0 5.7 6 1 0 6 6 6 2 HEAT repeats Cnd1 PF12717.7 PIK45797.1 - 1.4e-07 31.7 4.7 0.0068 16.5 0.0 4.7 3 3 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK45797.1 - 9.6e-06 26.0 11.2 2.8 8.5 0.0 7.3 6 1 1 7 7 7 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK45797.1 - 3.1e-05 24.5 1.7 12 6.5 0.0 5.4 4 2 1 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK45797.1 - 0.0055 16.3 4.6 0.025 14.2 0.3 3.6 3 1 0 3 3 3 1 CLASP N terminal Nipped-B_C PF12830.7 PIK45797.1 - 0.018 15.0 0.6 10 6.0 0.1 4.1 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus Imm51 PF15595.6 PIK45797.1 - 0.033 14.1 0.1 0.14 12.1 0.1 2.1 1 0 0 1 1 1 0 Immunity protein 51 Cohesin_HEAT PF12765.7 PIK45797.1 - 0.054 13.8 0.1 0.24 11.7 0.1 2.2 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion MAP65_ASE1 PF03999.12 PIK45797.1 - 0.092 11.4 0.1 0.18 10.5 0.1 1.4 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ERAP1_C PF11838.8 PIK45797.1 - 0.94 9.0 3.5 3.4 7.1 0.2 3.3 3 1 0 3 3 3 0 ERAP1-like C-terminal domain Globin PF00042.22 PIK45798.1 - 7e-35 119.9 1.5 3.8e-18 66.1 0.1 2.5 2 0 0 2 2 2 2 Globin FdsD PF11390.8 PIK45798.1 - 0.0044 17.3 0.3 8.9 6.7 0.0 4.2 4 1 0 4 4 4 1 NADH-dependant formate dehydrogenase delta subunit FdsD LuxT_C PF18285.1 PIK45798.1 - 0.0078 16.7 1.3 40 4.9 0.0 4.1 4 0 0 4 4 4 1 Tetracycline repressor LuxT C-terminal domain G_glu_transpept PF01019.21 PIK45801.1 - 0.076 11.8 0.0 0.081 11.7 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase RVT_1 PF00078.27 PIK45802.1 - 2e-32 112.5 0.5 1.6e-31 109.6 0.2 2.5 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK45802.1 - 2.1e-15 56.6 3.1 5e-15 55.3 3.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK45802.1 - 0.036 14.2 0.0 0.087 13.0 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.10 PIK45802.1 - 0.12 12.7 1.5 0.46 10.8 1.4 2.1 2 0 0 2 2 2 0 H2C2 zinc finger G_glu_transpept PF01019.21 PIK45803.1 - 3.7e-88 296.5 0.0 5.1e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RVT_1 PF00078.27 PIK45803.1 - 8.7e-33 113.7 0.0 1.4e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_6 PF13516.6 PIK45804.1 - 6.9e-09 35.1 2.1 0.00034 20.4 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 PIK45804.1 - 7.3e-05 23.1 3.0 0.21 12.1 0.1 3.4 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK45804.1 - 0.00035 20.4 0.4 0.00035 20.4 0.4 1.9 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 PIK45804.1 - 0.06 13.9 7.8 11 7.0 0.0 5.7 6 2 0 6 6 6 0 Leucine Rich Repeat Actin PF00022.19 PIK45805.1 - 5.3e-40 137.3 0.0 1.2e-38 132.9 0.0 2.1 1 1 0 1 1 1 1 Actin BORCS6 PF10157.9 PIK45805.1 - 0.025 14.8 1.4 0.031 14.5 0.0 1.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 PRK PF00485.18 PIK45806.1 - 7.4e-12 45.4 0.0 9.4e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CedA PF10729.9 PIK45806.1 - 0.17 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Cell division activator CedA Pkinase PF00069.25 PIK45807.1 - 2.5e-14 53.3 1.3 9.1e-08 31.8 0.5 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45807.1 - 0.011 15.0 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Taeniidae_ag PF05596.11 PIK45807.1 - 0.41 10.6 2.8 10 6.2 0.2 3.1 3 0 0 3 3 3 0 Taeniidae antigen DED PF01335.21 PIK45808.1 - 8.3e-06 26.0 2.0 1.7e-05 25.0 2.0 1.4 1 0 0 1 1 1 1 Death effector domain Peptidase_C14 PF00656.22 PIK45808.1 - 1.5e-05 25.1 0.0 2.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Trehalase PF01204.18 PIK45808.1 - 0.68 8.7 2.6 10 4.8 0.1 2.2 1 1 1 2 2 2 0 Trehalase TFIIB PF00382.19 PIK45809.1 - 9.1e-12 44.9 0.3 1.3e-11 44.4 0.3 1.2 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Sigma70_r4 PF04545.16 PIK45809.1 - 0.023 14.2 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 Snapin_Pallidin PF14712.6 PIK45810.1 - 1.2e-22 80.1 1.4 1.6e-22 79.8 1.4 1.1 1 0 0 1 1 1 1 Snapin/Pallidin Spc7 PF08317.11 PIK45810.1 - 0.004 16.1 3.1 0.0049 15.8 3.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Gag_p15 PF08723.10 PIK45810.1 - 0.0047 17.1 0.1 0.0058 16.8 0.1 1.1 1 0 0 1 1 1 1 Gag protein p15 Eisosome1 PF12757.7 PIK45810.1 - 0.021 15.1 2.6 0.071 13.4 0.3 2.1 2 0 0 2 2 2 0 Eisosome protein 1 PspA_IM30 PF04012.12 PIK45810.1 - 0.12 12.0 5.8 1.7 8.2 0.6 2.0 1 1 1 2 2 2 0 PspA/IM30 family DUF1664 PF07889.12 PIK45810.1 - 0.12 12.4 2.2 0.16 12.0 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 PIK45810.1 - 0.12 12.4 3.9 2.1 8.4 0.5 2.1 1 1 1 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 PIK45810.1 - 0.26 11.6 3.6 0.28 11.5 1.5 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FYVE_2 PF02318.16 PIK45810.1 - 0.27 11.4 1.7 0.34 11.1 0.1 1.8 1 1 1 2 2 2 0 FYVE-type zinc finger DivIC PF04977.15 PIK45810.1 - 0.98 9.2 5.8 1.7 8.4 2.3 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF16 PF01519.16 PIK45810.1 - 1.1 9.7 5.4 1.1 9.7 3.1 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 EURL PF06937.11 PIK45810.1 - 1.9 7.8 6.2 10 5.4 2.0 2.0 1 1 1 2 2 2 0 EURL protein Ham1p_like PF01725.16 PIK45811.1 - 7.6e-49 166.2 0.0 8.4e-48 162.8 0.0 2.1 1 1 0 1 1 1 1 Ham1 family FA_desaturase PF00487.24 PIK45812.1 - 0.0023 17.8 3.1 0.0032 17.3 3.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF1211 PF06736.11 PIK45812.1 - 0.076 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) FA_desaturase PF00487.24 PIK45813.1 - 9.3e-20 71.5 18.0 9.3e-20 71.5 18.0 1.4 2 0 0 2 2 2 1 Fatty acid desaturase DUF1761 PF08570.10 PIK45813.1 - 0.0021 18.3 2.1 0.098 12.9 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1761) TDP43_N PF18694.1 PIK45813.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Transactive response DNA-binding protein N-terminal domain DUF962 PF06127.11 PIK45813.1 - 1.5 9.0 8.7 1.3 9.2 3.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF962) RIC3 PF15361.6 PIK45814.1 - 0.021 15.2 1.1 0.053 13.9 1.0 1.7 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 FA_desaturase PF00487.24 PIK45815.1 - 1.4e-13 51.3 17.7 1.4e-13 51.3 17.7 1.6 1 1 1 2 2 2 1 Fatty acid desaturase FA_desaturase PF00487.24 PIK45816.1 - 1e-05 25.5 6.7 1.3e-05 25.1 6.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase PBP1_TM PF14812.6 PIK45817.1 - 0.0042 17.4 4.5 0.016 15.6 4.5 2.0 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 PIK45817.1 - 4.1 6.7 9.0 7 5.9 9.0 1.3 1 0 0 1 1 1 0 NOA36 protein EST1_DNA_bind PF10373.9 PIK45818.1 - 2.4e-22 79.7 3.0 3.7e-22 79.1 0.3 2.1 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 PIK45818.1 - 6.3e-20 72.2 1.5 8.4e-20 71.8 0.3 1.9 2 0 0 2 2 2 1 Telomerase activating protein Est1 DUF2278 PF10042.9 PIK45818.1 - 0.017 15.1 0.1 0.03 14.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) SPX PF03105.19 PIK45819.1 - 9.8e-22 78.4 17.8 1.9e-13 51.1 6.6 2.1 1 1 1 2 2 2 2 SPX domain EXS PF03124.14 PIK45819.1 - 0.013 14.9 0.5 0.039 13.3 0.1 1.8 2 0 0 2 2 2 0 EXS family TMEM135_C_rich PF15982.5 PIK45819.1 - 0.033 14.8 0.6 3.4 8.3 0.0 2.6 3 0 0 3 3 3 0 N-terminal cysteine-rich region of Transmembrane protein 135 EXS PF03124.14 PIK45820.1 - 6.3e-85 285.4 29.1 8e-85 285.1 29.1 1.0 1 0 0 1 1 1 1 EXS family MotB_plug PF13677.6 PIK45820.1 - 0.45 10.1 2.0 9.2 5.9 0.5 2.6 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB Med22 PF06179.12 PIK45821.1 - 1.6e-29 102.2 1.4 2.5e-29 101.6 1.4 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PKK PF12474.8 PIK45821.1 - 0.044 13.9 6.9 0.11 12.6 3.7 2.1 2 0 0 2 2 2 0 Polo kinase kinase Ribosomal_L29 PF00831.23 PIK45822.1 - 4.9e-21 74.5 3.0 4.9e-21 74.5 3.0 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein LURAP PF14854.6 PIK45822.1 - 0.029 14.3 0.3 0.046 13.7 0.3 1.4 1 0 0 1 1 1 0 Leucine rich adaptor protein Cytochrom_B561 PF03188.16 PIK45823.1 - 2.9e-42 144.0 11.9 4.1e-42 143.6 11.9 1.2 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 SUR7 PF06687.12 PIK45823.1 - 0.34 10.5 10.0 0.093 12.3 6.9 1.6 1 1 0 1 1 1 0 SUR7/PalI family ABC_trans_CmpB PF06541.11 PIK45823.1 - 2.6 8.3 12.7 0.046 14.0 3.8 2.2 2 1 0 2 2 2 0 Putative ABC-transporter type IV Ni_hydr_CYTB PF01292.20 PIK45823.1 - 7 6.2 22.5 4.7 6.8 2.8 2.6 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Rad51 PF08423.11 PIK45824.1 - 9.3e-12 44.7 0.0 0.00012 21.4 0.0 2.4 2 1 0 2 2 2 2 Rad51 Med16 PF11635.8 PIK45825.1 - 1.1e-22 79.8 0.0 2.4e-22 78.7 0.0 1.4 1 1 0 1 1 1 1 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 PIK45825.1 - 0.006 16.9 0.1 0.45 10.9 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK45825.1 - 0.64 11.0 2.3 46 5.1 0.0 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat Med16 PF11635.8 PIK45826.1 - 2.7e-14 52.1 0.5 1.4e-13 49.8 0.2 2.0 2 1 0 2 2 2 1 Mediator complex subunit 16 BAMBI PF06211.12 PIK45827.1 - 6.8e-09 35.9 10.6 3.8e-08 33.5 10.6 2.0 1 1 0 1 1 1 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Peptidase_C11 PF03415.14 PIK45828.1 - 0.03 13.8 0.2 0.037 13.4 0.2 1.2 1 0 0 1 1 1 0 Clostripain family Gal-3-0_sulfotr PF06990.11 PIK45830.1 - 1.3e-48 165.9 1.8 1.7e-48 165.5 1.8 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK45830.1 - 3.8e-05 23.3 0.0 6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase domain Enterotoxin_a PF01375.17 PIK45831.1 - 0.076 12.6 0.6 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 Heat-labile enterotoxin alpha chain BicD PF09730.9 PIK45831.1 - 0.26 9.6 0.0 0.34 9.3 0.0 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D Inhibitor_I53 PF11714.8 PIK45832.1 - 0.038 14.2 1.1 0.092 13.0 1.1 1.6 1 0 0 1 1 1 0 Thrombin inhibitor Madanin NARG2_C PF10505.9 PIK45834.1 - 4.4e-30 104.8 0.0 5.6e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus Mem_trans PF03547.18 PIK45835.1 - 4.2e-12 45.2 25.0 5.9e-09 34.8 6.9 2.5 2 1 0 3 3 3 2 Membrane transport protein IncE PF17627.2 PIK45835.1 - 1 9.4 8.9 0.55 10.3 1.6 2.5 2 0 0 2 2 2 0 Inclusion membrane protein E SOAR PF16533.5 PIK45837.1 - 1.2e-35 121.5 19.2 3.4e-35 120.0 3.2 2.9 2 1 0 2 2 2 2 STIM1 Orai1-activating region SAM_2 PF07647.17 PIK45837.1 - 1.2e-10 41.3 0.0 4e-10 39.7 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK45837.1 - 3e-09 37.2 0.0 1.3e-08 35.2 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) TraX PF05857.11 PIK45837.1 - 0.091 12.8 0.4 13 5.8 0.0 2.2 2 0 0 2 2 2 0 TraX protein SAM_Ste50p PF09235.10 PIK45837.1 - 0.12 12.6 0.1 0.59 10.4 0.0 2.1 2 0 0 2 2 2 0 Ste50p, sterile alpha motif Halogen_Hydrol PF10112.9 PIK45837.1 - 0.4 10.7 10.6 0.077 13.0 0.4 3.2 3 1 1 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein PI3K_P85_iSH2 PF16454.5 PIK45837.1 - 2 8.0 20.2 0.35 10.4 7.8 3.4 3 1 1 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain COG5 PF10392.9 PIK45837.1 - 2.1 8.6 7.1 0.41 10.8 0.6 2.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 DUF4407 PF14362.6 PIK45837.1 - 7.2 5.9 8.9 13 5.1 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DZR PF12773.7 PIK45839.1 - 0.0005 20.0 8.6 0.0095 15.9 6.6 2.5 2 0 0 2 2 2 1 Double zinc ribbon zf-ribbon_3 PF13248.6 PIK45839.1 - 0.0032 16.8 8.3 0.31 10.5 1.8 3.4 3 0 0 3 3 3 2 zinc-ribbon domain DUF5371 PF17341.2 PIK45839.1 - 0.03 14.5 0.1 3.9 7.7 0.1 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5371) zinc_ribbon_2 PF13240.6 PIK45839.1 - 0.031 14.0 8.0 1.5 8.6 2.8 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING_4 PF14570.6 PIK45839.1 - 0.071 12.9 10.5 0.27 11.1 6.4 2.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.12 PIK45839.1 - 0.075 13.3 16.8 0.41 11.0 7.2 3.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF4428 PF14471.6 PIK45839.1 - 0.24 11.4 5.6 1.8 8.6 0.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) zinc_ribbon_9 PF14369.6 PIK45839.1 - 0.56 10.5 12.7 8.1 6.8 3.4 3.7 3 1 0 3 3 3 0 zinc-ribbon Prok-RING_1 PF14446.6 PIK45839.1 - 4.5 7.3 11.9 21 5.2 2.0 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf_UBZ PF18439.1 PIK45839.1 - 5.6 6.6 11.5 3.8 7.2 1.8 3.7 3 1 0 3 3 3 0 Ubiquitin-Binding Zinc Finger WD40_3 PF15911.5 PIK45840.1 - 3.2e-26 91.1 0.8 5.8e-26 90.3 0.2 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Clathrin PF00637.20 PIK45840.1 - 2.8e-08 33.8 5.8 0.0047 16.8 0.0 4.2 3 1 2 5 5 5 2 Region in Clathrin and VPS TPR_14 PF13428.6 PIK45840.1 - 6.7e-05 23.4 0.3 1.2 10.2 0.4 5.2 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK45840.1 - 7.4e-05 22.5 2.9 3.5 7.9 0.1 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45840.1 - 0.0003 20.7 10.4 1.2 9.4 0.5 6.4 7 1 1 8 8 8 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 PIK45840.1 - 0.00054 19.1 4.5 0.13 11.3 0.2 3.0 3 0 0 3 3 3 2 Coatomer WD associated region TPR_1 PF00515.28 PIK45840.1 - 0.0011 18.6 10.6 2.6 8.0 0.0 6.5 7 1 0 7 7 7 1 Tetratricopeptide repeat Nic96 PF04097.14 PIK45840.1 - 0.002 16.7 1.2 0.018 13.5 0.2 2.1 1 1 0 2 2 2 1 Nup93/Nic96 TPR_8 PF13181.6 PIK45840.1 - 0.0047 17.0 7.2 2.7 8.4 0.4 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45840.1 - 0.0087 15.7 2.6 2.1 8.1 0.2 3.4 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 PIK45840.1 - 0.009 16.3 0.3 7.3 7.0 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK45840.1 - 0.023 15.2 0.4 3.4 8.3 0.0 3.7 3 1 1 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK45840.1 - 0.16 12.2 2.7 15 5.9 0.2 4.1 3 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 PIK45840.1 - 0.28 11.3 9.4 1.9 8.6 0.3 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Sarcoglycan_1 PF04790.13 PIK45841.1 - 8.3e-52 176.1 0.0 9.3e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 PIK45841.1 - 0.13 12.2 0.0 1.4 8.8 0.0 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) Myb_DNA-bind_7 PF15963.5 PIK45842.1 - 0.00039 20.3 1.0 0.001 18.9 0.1 2.2 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 PIK45842.1 - 0.017 15.3 0.0 0.055 13.7 0.0 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain FAM60A PF15396.6 PIK45844.1 - 1.3 8.9 11.3 1.6 8.7 11.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A OmpH PF03938.14 PIK45844.1 - 4.6 7.6 19.4 6 7.2 19.4 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PVL_ORF50 PF07768.11 PIK45844.1 - 9.1 6.6 22.9 13 6.1 22.5 1.4 1 1 0 1 1 1 0 PVL ORF-50-like family DUF5327 PF17261.2 PIK45845.1 - 0.99 10.2 7.7 3 8.7 7.7 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5327) SPT16 PF08644.11 PIK45845.1 - 1.2 9.3 15.2 0.74 10.0 13.1 1.6 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) Atg14 PF10186.9 PIK45845.1 - 1.3 8.1 15.5 1.5 7.8 15.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 La PF05383.17 PIK45846.1 - 3.1e-21 75.2 0.3 5.4e-21 74.4 0.3 1.4 1 0 0 1 1 1 1 La domain Sel1 PF08238.12 PIK45848.1 - 1.9e-31 107.8 20.1 7.6e-10 39.1 0.5 6.1 6 0 0 6 6 6 4 Sel1 repeat TPR_6 PF13174.6 PIK45848.1 - 7.1e-06 26.3 12.6 0.18 12.5 0.1 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK45848.1 - 1.6e-05 25.4 12.2 0.35 11.5 0.2 5.0 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK45848.1 - 0.03 15.1 7.4 41 5.4 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK45848.1 - 0.038 14.0 10.2 2.9 8.1 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK45848.1 - 0.081 12.8 0.0 2.7 8.0 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK45848.1 - 0.89 9.5 0.0 0.89 9.5 0.0 6.1 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45848.1 - 1 9.8 8.2 32 5.1 0.0 5.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45848.1 - 1.7 8.9 0.0 1.7 8.9 0.0 7.0 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45848.1 - 2.8 7.7 11.0 7.2 6.4 0.2 4.2 4 1 0 4 4 4 0 TPR repeat Pkinase PF00069.25 PIK45849.1 - 1.2e-70 237.9 0.0 1.7e-70 237.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK45849.1 - 2.7e-34 118.6 0.0 7.8e-34 117.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK45849.1 - 0.0017 18.3 0.6 0.12 12.3 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK45849.1 - 0.0022 17.6 0.2 0.0053 16.4 0.2 1.6 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 PIK45849.1 - 0.0065 16.1 0.1 0.93 9.1 0.0 2.4 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 PIK45849.1 - 0.022 13.7 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 PIK45849.1 - 0.022 14.1 0.0 0.093 12.0 0.0 1.8 1 1 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 PIK45849.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pro_isomerase PF00160.21 PIK45851.1 - 1.3e-48 165.3 0.3 2e-48 164.7 0.3 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 PIK45851.1 - 9.3e-16 56.9 8.2 1.1e-05 25.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK45851.1 - 2.1e-11 43.0 13.3 0.00032 20.6 0.8 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK45851.1 - 3.6e-06 27.5 5.4 0.18 12.5 1.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK45851.1 - 2.4e-05 24.2 9.4 0.068 13.4 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK45851.1 - 3.5e-05 23.9 2.9 7.2e-05 22.9 1.5 2.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK45851.1 - 0.00028 21.3 10.7 0.00072 20.0 1.8 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK45851.1 - 0.00074 19.8 6.6 3 8.2 0.2 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK45851.1 - 0.00089 18.9 2.3 0.025 14.3 0.0 3.2 2 1 1 3 3 3 1 TPR repeat TPR_6 PF13174.6 PIK45851.1 - 0.0018 18.8 5.0 8.1 7.3 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK45851.1 - 0.0088 16.8 5.9 1.4 9.9 1.4 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK45851.1 - 0.026 14.4 3.3 6 6.9 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 PIK45851.1 - 0.036 14.1 4.9 0.27 11.3 1.4 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 PIK45851.1 - 0.036 14.1 6.8 8.8 6.6 0.4 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4623 PF15416.6 PIK45851.1 - 0.066 11.8 0.0 0.095 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4623) ANAPC3 PF12895.7 PIK45851.1 - 0.11 12.7 3.6 0.4 10.9 3.6 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 PIK45851.1 - 0.17 12.3 4.3 13 6.5 0.6 3.4 3 1 0 3 3 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK45851.1 - 0.35 11.0 6.2 19 5.4 0.1 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat CLCA PF08434.11 PIK45852.1 - 3.1e-53 180.8 0.0 4.6e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA_2 PF13519.6 PIK45852.1 - 1.1e-11 45.4 0.0 2e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK45852.1 - 5.3e-11 43.1 0.0 8.5e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK45852.1 - 4.8e-06 26.1 0.0 1e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK45852.1 - 7.9e-06 25.9 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 PIK45852.1 - 0.096 12.8 0.1 0.84 9.7 0.1 2.2 1 1 0 1 1 1 0 vWA found in TerF C terminus Peptidase_M10 PF00413.24 PIK45853.1 - 1.8e-42 144.8 0.0 2.6e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 PIK45853.1 - 2.1e-08 34.2 0.0 6.2e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Astacin PF01400.24 PIK45853.1 - 0.00053 19.6 0.1 0.012 15.2 0.3 2.2 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 PIK45853.1 - 0.0049 16.5 0.0 0.0087 15.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 PIK45853.1 - 0.0053 15.4 0.0 0.0082 14.8 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 PIK45853.1 - 0.048 12.6 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 PIK45853.1 - 0.13 12.7 0.2 0.29 11.6 0.2 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK45853.1 - 0.14 11.4 0.5 0.24 10.6 0.5 1.3 1 0 0 1 1 1 0 Met-zincin HhH-GPD PF00730.25 PIK45854.1 - 3.9e-13 49.8 0.0 6e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 PIK45854.1 - 0.0083 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif G10 PF01125.17 PIK45855.1 - 2e-67 225.5 5.4 2.2e-67 225.4 5.4 1.0 1 0 0 1 1 1 1 G10 protein FPL PF09758.9 PIK45856.1 - 2.3e-15 56.9 0.2 2.7e-15 56.7 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Ig_6 PF18452.1 PIK45856.1 - 0.018 14.6 0.0 0.038 13.6 0.0 1.5 2 0 0 2 2 2 0 Immunoglobulin domain FPL PF09758.9 PIK45857.1 - 1.9e-09 37.7 0.2 4.1e-09 36.6 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein SOCS_box PF07525.16 PIK45859.1 - 4.7e-14 52.5 0.3 7.3e-14 51.8 0.3 1.3 1 0 0 1 1 1 1 SOCS box SH2 PF00017.24 PIK45859.1 - 1.9e-08 34.3 0.0 3.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Ras PF00071.22 PIK45861.1 - 2.3e-17 63.1 0.0 8.5e-17 61.2 0.0 1.9 2 1 1 3 3 3 1 Ras family Roc PF08477.13 PIK45861.1 - 0.0029 17.8 0.0 0.0047 17.1 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FAM167 PF11652.8 PIK45862.1 - 4.5e-14 52.7 7.0 5.2e-14 52.5 3.9 2.3 2 0 0 2 2 2 1 FAM167 Caps_synth_GfcC PF06251.11 PIK45862.1 - 0.036 13.7 3.7 0.044 13.4 3.7 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC DUF4404 PF14357.6 PIK45862.1 - 0.049 14.3 2.5 0.049 14.3 2.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Dapper PF15268.6 PIK45862.1 - 0.052 12.4 4.5 0.051 12.5 4.5 1.1 1 0 0 1 1 1 0 Dapper LURAP PF14854.6 PIK45862.1 - 0.23 11.4 5.8 0.13 12.2 2.6 2.1 1 1 2 3 3 3 0 Leucine rich adaptor protein AMP-binding PF00501.28 PIK45863.1 - 1.8e-92 310.1 0.0 2.3e-92 309.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF2956 PF11169.8 PIK45863.1 - 0.00019 21.5 1.3 0.00039 20.6 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) DUF2675 PF11247.8 PIK45863.1 - 0.096 12.8 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) NAD_binding_2 PF03446.15 PIK45864.1 - 0.075 13.2 2.1 0.079 13.1 2.1 1.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PARP PF00644.20 PIK45865.1 - 5.5e-29 101.2 0.0 7.9e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain COMM_domain PF07258.14 PIK45865.1 - 1.9e-10 40.7 0.1 4.8e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 COMM domain PARP_reg PF02877.14 PIK45865.1 - 4.8e-05 23.5 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain UPF0669 PF17065.5 PIK45866.1 - 5.3e-41 140.4 0.8 1.4e-40 139.0 0.8 1.5 1 1 0 1 1 1 1 Putative cytokine, C6ORF120 PPC PF04151.15 PIK45866.1 - 0.019 16.1 0.6 0.034 15.2 0.2 1.5 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain EGF_CA PF07645.15 PIK45867.1 - 3.7e-147 478.3 343.2 3.6e-10 39.9 7.4 23.2 22 1 1 23 23 23 22 Calcium-binding EGF domain cEGF PF12662.7 PIK45867.1 - 2.7e-71 235.0 187.4 6.1e-07 29.3 1.3 23.8 23 1 0 23 23 23 22 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK45867.1 - 6.3e-44 147.9 264.0 7.5e-05 22.8 4.7 23.8 22 2 0 23 23 23 18 EGF domain EGF PF00008.27 PIK45867.1 - 1.4e-43 146.8 306.1 1.2e-05 25.5 6.5 23.7 23 0 0 23 23 23 19 EGF-like domain FXa_inhibition PF14670.6 PIK45867.1 - 6.3e-42 141.6 305.6 0.00045 20.4 4.5 22.9 20 3 3 23 23 23 21 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK45867.1 - 1e-28 98.9 318.4 0.00079 20.0 8.8 25.7 26 0 0 26 26 26 18 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK45867.1 - 1.3e-07 31.8 244.1 0.0037 17.5 2.7 22.1 20 1 2 22 22 22 12 Pvs28 EGF domain EGF_2 PF07974.13 PIK45867.1 - 0.0036 17.7 23.2 0.0066 16.8 8.2 24.9 22 3 3 25 25 25 12 EGF-like domain DNA_ligase_OB_2 PF14743.6 PIK45867.1 - 0.84 9.7 4.8 17 5.5 0.0 4.4 6 0 0 6 6 6 0 DNA ligase OB-like domain TB PF00683.17 PIK45868.1 - 6.9e-12 44.9 6.4 6.9e-12 44.9 6.4 2.2 2 0 0 2 2 2 1 TB domain EGF_CA PF07645.15 PIK45868.1 - 7.4e-08 32.5 9.3 7.4e-08 32.5 9.3 4.4 4 1 0 4 4 4 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK45868.1 - 0.0007 19.8 7.1 0.0007 19.8 7.1 4.1 4 1 0 4 4 4 3 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK45868.1 - 0.0034 17.6 34.4 0.1 13.0 5.0 4.1 3 0 0 3 3 3 2 EGF-like domain EGF_3 PF12947.7 PIK45868.1 - 0.017 15.3 3.2 0.017 15.3 3.2 4.4 4 0 0 4 4 4 0 EGF domain hEGF PF12661.7 PIK45868.1 - 0.027 15.1 36.9 0.11 13.2 5.5 4.4 4 0 0 4 4 4 0 Human growth factor-like EGF cEGF PF12662.7 PIK45868.1 - 0.03 14.2 1.2 0.03 14.2 1.2 4.4 4 0 0 4 4 4 0 Complement Clr-like EGF-like Mito_carr PF00153.27 PIK45870.1 - 3.8e-26 90.8 1.1 1.1e-13 50.9 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein GrpE PF01025.19 PIK45871.1 - 0.0053 16.4 17.0 0.14 11.8 2.4 2.2 2 0 0 2 2 2 2 GrpE UPF0242 PF06785.11 PIK45871.1 - 0.0083 16.3 10.7 0.0083 16.3 10.7 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 PIK45871.1 - 0.017 15.4 19.9 1.3 9.4 2.9 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.6 PIK45871.1 - 0.018 13.7 14.0 0.034 12.8 1.9 2.1 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 PIK45871.1 - 0.029 13.9 13.9 0.072 12.6 2.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit ERM PF00769.19 PIK45871.1 - 0.076 12.8 28.0 0.1 12.4 7.2 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family YlqD PF11068.8 PIK45871.1 - 0.16 12.4 20.6 0.93 9.9 7.0 2.5 2 0 0 2 2 2 0 YlqD protein Atg14 PF10186.9 PIK45871.1 - 0.16 11.0 24.2 0.63 9.1 7.7 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 PIK45871.1 - 0.48 10.5 19.3 0.19 11.8 4.8 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Tho2 PF11262.8 PIK45871.1 - 0.83 8.8 16.0 1.1 8.4 5.1 2.4 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Phage_Mu_Gam PF07352.12 PIK45871.1 - 0.84 9.5 21.2 0.3 11.0 2.2 2.7 2 1 0 2 2 2 0 Bacteriophage Mu Gam like protein Phage_Orf51 PF06194.11 PIK45871.1 - 1 9.4 0.0 1 9.4 0.0 2.6 2 1 0 2 2 2 0 Phage Conserved Open Reading Frame 51 DUF4337 PF14235.6 PIK45871.1 - 2.2 8.4 16.5 1.3 9.1 4.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) TMPIT PF07851.13 PIK45871.1 - 3.5 6.8 19.9 1.5 8.0 7.1 2.2 2 0 0 2 2 2 0 TMPIT-like protein Hira PF07569.11 PIK45871.1 - 3.9 7.1 8.7 0.22 11.2 2.4 1.9 2 0 0 2 2 2 0 TUP1-like enhancer of split DLP_helical PF18709.1 PIK45871.1 - 4.8 6.3 16.4 2.2 7.4 7.3 2.8 2 1 0 2 2 2 0 Dynamin-like helical domain GLE1 PF07817.13 PIK45871.1 - 5.9 6.0 8.7 10 5.2 2.1 2.2 2 0 0 2 2 2 0 GLE1-like protein Spc7 PF08317.11 PIK45871.1 - 6.2 5.6 31.1 1.1 8.0 8.7 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein SH3_9 PF14604.6 PIK45872.1 - 2.5e-10 40.1 0.0 5.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain O-FucT PF10250.9 PIK45872.1 - 0.0015 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SH3_1 PF00018.28 PIK45872.1 - 0.0046 16.5 0.1 0.025 14.2 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 PIK45872.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain HGTP_anticodon2 PF12745.7 PIK45872.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs WD40_like PF17005.5 PIK45874.1 - 0.0037 16.6 0.8 0.36 10.1 0.2 2.3 1 1 1 2 2 2 2 WD40-like domain Frtz PF11768.8 PIK45875.1 - 0.061 11.6 0.0 0.07 11.4 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz MULE PF10551.9 PIK45876.1 - 4.1e-05 23.9 0.0 0.00014 22.2 0.0 2.0 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 PIK45876.1 - 0.018 13.9 0.2 0.027 13.4 0.2 1.1 1 0 0 1 1 1 0 Transposase, Mutator family zf-RING_UBOX PF13445.6 PIK45877.1 - 1.8e-09 37.5 6.4 1.8e-09 37.5 6.4 3.6 5 0 0 5 5 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK45877.1 - 9.5e-09 35.0 8.8 9.5e-09 35.0 8.8 3.8 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK45877.1 - 5.3e-07 29.9 7.6 5.3e-07 29.9 7.6 4.2 4 0 0 4 4 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK45877.1 - 8.2e-07 29.1 8.7 8.2e-07 29.1 8.7 4.3 4 2 0 4 4 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK45877.1 - 9.6e-07 28.6 6.6 9.6e-07 28.6 6.6 4.1 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK45877.1 - 1e-06 28.5 9.9 1e-06 28.5 9.9 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK45877.1 - 1.8e-05 24.8 27.8 0.00013 22.1 12.2 4.6 5 0 0 5 5 4 2 B-box zinc finger zf-RING_5 PF14634.6 PIK45877.1 - 0.00013 21.9 7.8 0.00013 21.9 7.8 3.9 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK45877.1 - 0.002 18.0 6.9 0.002 18.0 6.9 3.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 DUF885 PF05960.11 PIK45877.1 - 0.01 15.5 5.0 0.015 15.0 5.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF2315 PF10231.9 PIK45877.1 - 0.2 11.8 3.2 18 5.4 0.0 2.6 2 0 0 2 2 2 0 Apoptogenic protein 1 DUF948 PF06103.11 PIK45877.1 - 0.96 9.8 4.2 20 5.5 0.9 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PCRF PF03462.18 PIK45877.1 - 3.3 7.5 16.7 0.039 13.8 2.1 3.1 1 1 2 3 3 3 0 PCRF domain Cor1 PF04803.12 PIK45877.1 - 6.5 7.0 21.4 0.12 12.6 8.2 2.7 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF4407 PF14362.6 PIK45877.1 - 8.1 5.7 15.1 5.3 6.3 12.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) zf-C3HC4 PF00097.25 PIK45879.1 - 6e-07 29.2 4.1 6e-07 29.2 4.1 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK45879.1 - 2.7e-06 27.4 39.6 1.4e-05 25.1 9.1 4.8 5 0 0 5 5 5 2 B-box zinc finger zf-RING_2 PF13639.6 PIK45879.1 - 3.7e-06 27.2 3.9 3.7e-06 27.2 3.9 3.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK45879.1 - 8.8e-06 25.6 2.0 8.8e-06 25.6 2.0 2.9 4 0 0 4 4 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK45879.1 - 8.8e-05 22.3 4.6 8.8e-05 22.3 4.6 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK45879.1 - 0.00014 21.7 4.2 0.00014 21.7 4.2 3.9 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK45879.1 - 0.00065 19.8 3.8 0.00065 19.8 3.8 4.0 4 2 0 4 4 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 PIK45879.1 - 0.022 14.5 0.7 0.078 12.7 0.7 2.0 1 0 0 1 1 1 0 RING-like zinc finger BshC PF10079.9 PIK45879.1 - 0.031 13.0 4.2 0.056 12.2 4.2 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC DUF885 PF05960.11 PIK45879.1 - 0.12 12.0 1.2 0.18 11.4 1.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Siva PF05458.12 PIK45879.1 - 0.25 11.0 18.3 0.07 12.8 2.0 3.7 3 0 0 3 3 3 0 Cd27 binding protein (Siva) PCRF PF03462.18 PIK45879.1 - 0.45 10.4 9.4 0.039 13.8 1.6 2.4 1 1 2 3 3 3 0 PCRF domain Exonuc_VII_L PF02601.15 PIK45879.1 - 0.47 10.0 7.2 0.89 9.1 7.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cor1 PF04803.12 PIK45879.1 - 0.87 9.8 12.6 0.021 15.1 3.1 2.4 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF4407 PF14362.6 PIK45879.1 - 0.92 8.8 11.7 0.38 10.1 9.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Apolipoprotein PF01442.18 PIK45879.1 - 1.2 9.0 7.9 2.2 8.1 7.9 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain zf-C3HC4 PF00097.25 PIK45880.1 - 7.4e-09 35.3 7.5 7.4e-09 35.3 7.5 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK45880.1 - 8.2e-09 35.3 6.3 8.2e-09 35.3 6.3 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK45880.1 - 2.5e-06 27.7 6.9 2.5e-06 27.7 6.9 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK45880.1 - 6.5e-06 25.9 6.1 6.5e-06 25.9 6.1 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK45880.1 - 7.5e-06 26.0 8.8 7.5e-06 26.0 8.8 4.0 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK45880.1 - 8.6e-06 25.5 8.4 8.6e-06 25.5 8.4 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK45880.1 - 2.3e-05 24.4 39.3 0.00039 20.5 11.6 4.3 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 PIK45880.1 - 0.00028 20.8 7.9 0.00028 20.8 7.9 3.7 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK45880.1 - 0.0023 17.8 6.3 0.0023 17.8 6.3 3.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 Trm112p PF03966.16 PIK45880.1 - 4 8.1 12.5 2.3 8.9 1.9 4.3 3 1 1 4 4 4 0 Trm112p-like protein Glyco_transf_29 PF00777.18 PIK45883.1 - 1.3e-29 103.5 0.0 1.7e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK45884.1 - 8e-36 123.8 0.2 1.4e-35 123.0 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Rap_GAP PF02145.15 PIK45885.1 - 9.2e-39 132.9 0.0 1.4e-38 132.3 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 PIK45886.1 - 2e-118 395.6 4.7 4.2e-118 394.5 4.7 1.6 1 0 0 1 1 1 1 Tuberin DUF3384 PF11864.8 PIK45886.1 - 9.6e-79 265.5 2.3 3.3e-78 263.7 2.3 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) HEAT PF02985.22 PIK45886.1 - 0.00077 19.5 0.4 0.13 12.6 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat Axin_b-cat_bind PF08833.10 PIK45887.1 - 2.4e-08 33.9 2.2 2.4e-08 33.9 2.2 2.2 2 0 0 2 2 2 1 Axin beta-catenin binding domain Caskin-tail PF16632.5 PIK45887.1 - 0.46 10.9 3.5 0.26 11.7 0.4 2.2 2 0 0 2 2 2 0 C-terminal region of Caskin ALMT PF11744.8 PIK45887.1 - 0.47 9.2 7.1 0.71 8.6 7.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SYCP2_SLD PF18584.1 PIK45888.1 - 0.033 14.4 0.7 71 3.7 0.1 5.0 6 0 0 6 6 6 0 Synaptonemal complex 2 Spt16M-like domain Cucumo_2B PF03263.13 PIK45889.1 - 0.033 14.7 0.0 11 6.5 0.0 2.5 2 0 0 2 2 2 0 Cucumovirus protein 2B Aminotran_5 PF00266.19 PIK45890.1 - 2.5e-53 181.4 0.0 2.8e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V HemeBinding_Shp PF11545.8 PIK45890.1 - 0.029 14.3 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Cell surface heme-binding protein Shp HD_4 PF13328.6 PIK45891.1 - 5.9e-16 58.6 0.0 8.5e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 HD domain HD PF01966.22 PIK45891.1 - 5.5e-06 26.6 0.5 1.9e-05 24.9 0.5 1.8 1 1 0 1 1 1 1 HD domain SAM_PNT PF02198.16 PIK45891.1 - 0.036 14.0 0.7 0.11 12.5 0.6 1.9 1 1 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Mnd1 PF03962.15 PIK45891.1 - 0.11 12.8 0.6 6.3 7.2 0.0 3.0 3 0 0 3 3 3 0 Mnd1 HTH domain DUF1899 PF08953.11 PIK45892.1 - 9.8e-29 99.0 0.5 2.5e-28 97.7 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 PIK45892.1 - 2.7e-18 65.6 0.0 5.2e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 PIK45892.1 - 1.5e-11 44.7 0.7 0.00064 20.5 0.2 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK45892.1 - 1.8e-05 24.9 0.0 0.037 14.3 0.0 2.9 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK45892.1 - 0.026 13.5 0.0 0.11 11.4 0.0 2.0 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 PIK45892.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain WSD PF15613.6 PIK45892.1 - 1.1 9.7 4.9 0.24 11.9 0.4 2.2 2 0 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif UPF0449 PF15136.6 PIK45892.1 - 1.5 9.3 7.5 2.3 8.7 4.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DivIC PF04977.15 PIK45892.1 - 1.6 8.6 4.8 7.9 6.3 4.4 2.3 2 0 0 2 2 2 0 Septum formation initiator LRR_9 PF14580.6 PIK45894.1 - 8.7e-17 61.2 1.6 1.7e-16 60.3 1.6 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK45894.1 - 9.3e-15 54.5 14.2 1.4e-08 34.9 4.3 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK45894.1 - 1.5e-07 31.1 12.2 0.00019 21.1 3.2 3.1 1 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 PIK45894.1 - 1.6e-05 24.5 9.8 0.45 10.7 2.0 4.3 3 0 0 3 3 3 3 Leucine Rich repeat LRR_2 PF07723.13 PIK45894.1 - 0.01 16.5 5.6 2.4 9.0 0.1 4.2 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_1 PF00560.33 PIK45894.1 - 0.021 15.3 14.2 4.1 8.3 0.6 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_5 PF13306.6 PIK45894.1 - 0.047 13.7 0.3 0.077 13.0 0.3 1.4 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) Cwf_Cwc_15 PF04889.12 PIK45894.1 - 0.076 12.7 10.9 0.094 12.4 10.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CobT PF06213.12 PIK45894.1 - 0.18 11.2 7.9 0.24 10.7 7.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 PIK45894.1 - 0.26 11.0 3.7 0.44 10.2 3.7 1.4 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 PIK45894.1 - 0.34 10.3 13.3 0.53 9.7 13.3 1.2 1 0 0 1 1 1 0 SDA1 DUF2722 PF10846.8 PIK45894.1 - 0.4 9.6 5.4 0.51 9.2 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 PIK45894.1 - 1 9.3 12.1 1.1 9.2 12.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_3_Rpc31 PF11705.8 PIK45894.1 - 1.2 9.3 13.7 1.5 9.1 13.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 PIK45894.1 - 1.4 7.0 13.5 1.8 6.7 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 PIK45894.1 - 2.1 6.5 8.9 2.7 6.2 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Abhydrolase_1 PF00561.20 PIK45895.1 - 4.5e-14 52.7 0.0 1.1e-13 51.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 PIK45895.1 - 1.3e-12 47.4 0.0 1.8e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 PIK45895.1 - 2.9e-10 41.1 0.0 4.2e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK45895.1 - 6.5e-10 38.7 0.0 3.7e-09 36.2 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 PIK45895.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_5 PF12695.7 PIK45895.1 - 0.14 11.9 0.0 2.9 7.6 0.1 2.7 2 1 0 2 2 2 0 Alpha/beta hydrolase family NAC PF01849.18 PIK45896.1 - 1.3e-22 79.5 0.0 3.1e-22 78.3 0.0 1.7 1 0 0 1 1 1 1 NAC domain SEEEED PF14797.6 PIK45896.1 - 0.07 13.3 8.8 0.11 12.7 8.8 1.2 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex UBA_4 PF14555.6 PIK45896.1 - 0.13 12.1 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain NCD1 PF04904.13 PIK45898.1 - 4.6e-37 125.9 0.2 8.2e-37 125.1 0.2 1.4 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) NCD2 PF04905.13 PIK45898.1 - 1.3e-20 73.6 0.2 2.8e-20 72.5 0.1 1.6 2 0 0 2 2 2 1 NAB conserved region 2 (NCD2) RT_RNaseH_2 PF17919.1 PIK45899.1 - 4e-28 97.4 0.0 9.5e-28 96.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45899.1 - 3.1e-24 85.3 0.0 1.5e-23 83.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK45899.1 - 5.6e-24 84.6 0.1 1.1e-23 83.7 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK45899.1 - 5.8e-20 71.2 0.7 1.3e-19 70.0 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK45899.1 - 4.1e-16 59.2 0.1 9.2e-16 58.0 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK45899.1 - 7.8e-05 22.4 0.2 0.00092 18.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK45899.1 - 0.065 13.5 0.7 0.14 12.4 0.7 1.6 1 0 0 1 1 1 0 H2C2 zinc finger gag-asp_proteas PF13975.6 PIK45900.1 - 8.5e-08 32.7 0.0 1.6e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK45900.1 - 0.00035 21.2 0.1 0.00067 20.2 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK45900.1 - 0.017 15.4 0.0 0.038 14.3 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease SQAPI PF16845.5 PIK45900.1 - 0.095 13.1 0.1 0.18 12.2 0.1 1.4 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Ribosomal_L14 PF00238.19 PIK45901.1 - 3e-36 124.2 0.7 3.8e-36 123.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e LMBR1 PF04791.16 PIK45902.1 - 3.7e-79 267.0 28.3 7.1e-49 167.1 10.0 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein APG6_N PF17675.1 PIK45902.1 - 0.0099 16.4 2.3 0.016 15.7 2.3 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region Otopetrin PF03189.13 PIK45902.1 - 0.014 14.2 4.1 1.1 8.0 0.1 2.3 1 1 1 2 2 2 0 Otopetrin DUF3671 PF12420.8 PIK45902.1 - 0.51 10.4 6.6 3.4 7.8 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function PAP2 PF01569.21 PIK45903.1 - 7.3e-15 54.9 0.8 7.3e-15 54.9 0.8 2.1 2 0 0 2 2 2 1 PAP2 superfamily ddrB-ParB PF18763.1 PIK45904.1 - 0.47 10.6 6.6 45 4.2 0.0 4.2 4 0 0 4 4 4 0 ddrB-like ParB superfamily domain Glycohydro_20b2 PF14845.6 PIK45904.1 - 0.64 10.7 6.0 0.76 10.4 0.7 2.5 2 0 0 2 2 2 0 beta-acetyl hexosaminidase like DUF4178 PF13785.6 PIK45905.1 - 0.094 12.8 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) Nup54_57_C PF18570.1 PIK45906.1 - 0.0099 15.4 0.9 0.058 13.0 0.1 2.5 2 0 0 2 2 2 1 NUP57/Nup54 C-terminal domain HIP1_clath_bdg PF16515.5 PIK45906.1 - 0.034 14.8 1.3 0.034 14.8 1.3 4.1 3 1 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NPV_P10 PF05531.12 PIK45906.1 - 0.035 14.6 7.0 1 9.8 0.3 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein NAPRTase_N PF17767.1 PIK45906.1 - 0.075 13.4 1.5 1.5 9.3 0.5 2.6 2 1 1 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain FUSC PF04632.12 PIK45906.1 - 0.49 8.9 7.3 0.93 8.0 7.0 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family Fez1 PF06818.15 PIK45906.1 - 1.8 9.0 33.9 25 5.2 29.8 2.7 2 1 0 2 2 2 0 Fez1 JIP_LZII PF16471.5 PIK45906.1 - 3.6 7.8 27.6 0.63 10.2 2.9 4.6 4 1 0 4 4 4 0 JNK-interacting protein leucine zipper II ERM PF00769.19 PIK45906.1 - 5.4 6.8 44.1 0.47 10.2 34.1 2.6 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DUF3450 PF11932.8 PIK45906.1 - 6.7 5.9 31.8 0.43 9.9 9.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) KH_1 PF00013.29 PIK45907.1 - 4.4e-25 87.3 3.6 4.2e-19 68.1 1.2 2.3 2 0 0 2 2 2 2 KH domain Alba PF01918.21 PIK45907.1 - 0.0016 18.2 0.0 0.16 11.8 0.0 2.5 2 1 0 2 2 2 1 Alba KH_2 PF07650.17 PIK45907.1 - 0.0042 16.9 1.3 0.0082 15.9 1.3 1.5 1 1 0 1 1 1 1 KH domain MOEP19 PF16005.5 PIK45907.1 - 0.012 15.6 0.0 0.035 14.1 0.0 1.7 2 0 0 2 2 2 0 KH-like RNA-binding domain KH_1 PF00013.29 PIK45908.1 - 2.1e-11 43.5 0.1 2.8e-11 43.1 0.1 1.2 1 0 0 1 1 1 1 KH domain RabGAP-TBC PF00566.18 PIK45909.1 - 8.4e-54 182.5 0.8 8.4e-54 182.5 0.8 1.8 2 1 0 2 2 2 1 Rab-GTPase-TBC domain bZIP_2 PF07716.15 PIK45909.1 - 0.12 12.4 5.4 0.42 10.7 5.4 2.0 1 0 0 1 1 1 0 Basic region leucine zipper CDO_I PF05995.12 PIK45910.1 - 0.013 14.9 0.4 0.024 14.0 0.4 1.4 1 0 0 1 1 1 0 Cysteine dioxygenase type I RR_TM4-6 PF06459.12 PIK45910.1 - 4.9 6.9 15.4 7.1 6.4 15.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Myb_DNA-binding PF00249.31 PIK45912.1 - 2e-40 136.8 23.9 1.6e-10 41.0 0.2 6.0 6 1 0 6 6 6 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK45912.1 - 1.3e-30 105.4 11.0 4.7e-10 39.6 0.3 6.2 3 1 3 6 6 6 5 Myb-like DNA-binding domain SLIDE PF09111.10 PIK45912.1 - 2.8e-06 27.3 5.0 0.0087 16.1 0.0 4.2 4 1 1 5 5 5 2 SLIDE Myb_DNA-bind_5 PF13873.6 PIK45912.1 - 5.1 7.2 10.1 67 3.7 0.0 5.4 6 0 0 6 6 6 0 Myb/SANT-like DNA-binding domain PRKCSH-like PF12999.7 PIK45912.1 - 8.6 6.1 8.0 4.3 7.1 0.4 3.2 3 0 0 3 3 3 0 Glucosidase II beta subunit-like V-ATPase_G PF03179.15 PIK45913.1 - 1.8e-33 115.2 20.0 2e-33 115.0 20.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 PIK45913.1 - 0.0033 17.8 18.4 0.0044 17.4 18.4 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 PIK45913.1 - 0.024 14.1 19.9 0.034 13.6 19.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) vATP-synt_E PF01991.18 PIK45913.1 - 0.077 12.4 17.2 0.11 11.9 17.2 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF3347 PF11827.8 PIK45913.1 - 0.2 11.8 6.3 0.25 11.5 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Con-6 PF10346.9 PIK45913.1 - 0.2 11.7 3.3 0.67 10.0 3.3 1.8 1 0 0 1 1 1 0 Conidiation protein 6 RRF PF01765.19 PIK45913.1 - 0.31 11.0 17.0 0.4 10.6 17.0 1.2 1 0 0 1 1 1 0 Ribosome recycling factor DUF4378 PF14309.6 PIK45913.1 - 0.45 10.9 5.3 0.51 10.7 4.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4378) Exonuc_VII_L PF02601.15 PIK45913.1 - 0.6 9.6 9.8 0.7 9.4 9.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit HrpE PF06188.12 PIK45913.1 - 0.61 9.9 9.4 0.81 9.5 9.4 1.2 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF3584 PF12128.8 PIK45913.1 - 0.83 7.1 17.8 0.9 7.0 17.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 PIK45913.1 - 1.3 8.3 8.9 1.6 8.0 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mitoc_mL59 PF18126.1 PIK45913.1 - 1.4 9.3 9.5 1.9 8.8 9.5 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein mL59 FAM60A PF15396.6 PIK45913.1 - 1.5 8.8 6.8 1.7 8.6 6.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A ATP-synt_B PF00430.18 PIK45913.1 - 2.8 8.0 23.9 7.2 6.7 23.8 1.7 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) ZYG-11_interact PF05884.12 PIK45913.1 - 3 7.2 3.9 4.1 6.7 3.9 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 OmpH PF03938.14 PIK45913.1 - 3.3 8.1 23.4 4.7 7.6 23.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MtaB PF12176.8 PIK45913.1 - 3.7 6.2 6.8 4.1 6.1 6.8 1.1 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit Sds3 PF08598.11 PIK45913.1 - 3.7 7.5 18.6 4 7.4 0.7 2.0 1 1 1 2 2 2 0 Sds3-like HSP70 PF00012.20 PIK45913.1 - 4.2 5.4 12.8 4.9 5.2 12.8 1.0 1 0 0 1 1 1 0 Hsp70 protein TMPIT PF07851.13 PIK45913.1 - 4.9 6.3 9.2 5.9 6.0 9.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.9 PIK45913.1 - 5 6.1 14.4 6 5.9 14.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4375 PF14300.6 PIK45913.1 - 5.5 7.3 10.6 25 5.2 6.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) DUF883 PF05957.13 PIK45913.1 - 6.9 7.4 13.7 54 4.5 13.7 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) LMBR1 PF04791.16 PIK45913.1 - 6.9 5.5 7.4 7.8 5.3 7.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Sushi PF00084.20 PIK45914.1 - 2.4e-70 233.0 55.3 9.2e-12 45.4 0.5 9.5 9 0 0 9 9 9 8 Sushi repeat (SCR repeat) HRM PF02793.22 PIK45914.1 - 0.025 14.9 0.5 0.025 14.9 0.5 7.1 6 1 1 7 7 7 0 Hormone receptor domain DUF281 PF03436.13 PIK45914.1 - 0.75 10.2 24.8 0.54 10.7 0.5 6.1 6 2 1 7 7 7 0 Domain of unknown function (DUF281) cEGF PF12662.7 PIK45914.1 - 4.8 7.2 36.3 3.9 7.5 0.3 8.5 8 0 0 8 8 8 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK45915.1 - 6.6e-22 77.9 4.1 4.1e-11 43.3 0.3 2.0 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.22 PIK45915.1 - 0.0095 16.2 2.8 0.21 11.9 0.2 2.2 2 0 0 2 2 2 2 Hormone receptor domain cEGF PF12662.7 PIK45915.1 - 8.1 6.5 7.6 12 5.9 0.2 2.8 3 0 0 3 3 3 0 Complement Clr-like EGF-like Chromo PF00385.24 PIK45916.1 - 2.8e-08 33.5 0.0 6.4e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 PIK45916.1 - 0.084 12.8 0.8 0.42 10.5 0.2 2.1 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain G8 PF10162.9 PIK45917.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 G8 domain THAP PF05485.12 PIK45918.1 - 4.3e-13 50.0 2.5 4.6e-13 49.9 0.7 2.1 2 0 0 2 2 2 1 THAP domain NOG1 PF06858.14 PIK45919.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) PDGF PF00341.17 PIK45920.1 - 7.7e-09 35.7 4.2 7.7e-09 35.7 4.2 2.9 2 1 1 3 3 3 1 PDGF/VEGF domain Phage_int_SAM_4 PF13495.6 PIK45921.1 - 0.01 16.3 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK45921.1 - 0.015 15.6 1.3 0.026 14.8 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain V-set PF07686.17 PIK45922.1 - 0.00021 21.4 0.0 0.00029 21.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Na_H_Exchanger PF00999.21 PIK45923.1 - 4.4e-13 48.8 14.5 5.6e-13 48.4 14.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RVT_1 PF00078.27 PIK45924.1 - 1.5e-54 184.8 0.1 1.5e-54 184.8 0.1 2.1 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK45924.1 - 5e-14 52.2 1.5 2.6e-12 46.6 0.3 3.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK45924.1 - 0.01 15.4 0.0 0.031 13.8 0.0 1.8 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family DUF1101 PF06503.11 PIK45924.1 - 0.057 12.7 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1101) Dmrt1 PF12374.8 PIK45925.1 - 0.19 12.2 5.1 2.4 8.7 0.4 2.8 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 TGF_beta PF00019.20 PIK45926.1 - 8.1e-26 91.0 0.5 1.4e-25 90.2 0.5 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 PIK45926.1 - 4e-10 39.9 0.0 1.2e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 TGF-beta propeptide Hormone_6 PF00236.18 PIK45926.1 - 0.084 12.9 0.5 0.17 11.9 0.5 1.5 1 0 0 1 1 1 0 Glycoprotein hormone CHCH PF06747.13 PIK45927.1 - 1.9e-08 34.2 3.3 2.7e-08 33.7 3.3 1.2 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 PIK45927.1 - 0.068 13.2 2.1 0.25 11.4 2.2 1.8 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, MTCP1 PF08991.10 PIK45927.1 - 0.072 13.3 1.5 0.12 12.7 1.5 1.4 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type NDUF_B7 PF05676.13 PIK45927.1 - 0.086 12.6 1.2 0.15 11.8 1.2 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) OAR PF03826.17 PIK45928.1 - 0.00097 18.9 1.3 0.0018 18.0 1.3 1.4 1 0 0 1 1 1 1 OAR domain Homeodomain PF00046.29 PIK45928.1 - 0.06 13.2 7.3 0.12 12.2 7.3 1.5 1 0 0 1 1 1 0 Homeodomain HEAT PF02985.22 PIK45929.1 - 0.25 11.7 1.4 3.5 8.1 0.4 2.7 2 0 0 2 2 2 0 HEAT repeat Sec7 PF01369.20 PIK45931.1 - 6.2e-64 215.1 0.5 1.1e-63 214.2 0.5 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 PIK45931.1 - 2.1e-30 105.7 4.0 2.1e-30 105.7 4.0 3.5 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Nop14 PF04147.12 PIK45931.1 - 5 5.2 18.6 7.9 4.6 18.6 1.2 1 0 0 1 1 1 0 Nop14-like family BTB PF00651.31 PIK45933.1 - 2.4e-14 53.5 0.0 3.3e-13 49.8 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK45933.1 - 0.0022 18.1 0.1 0.018 15.2 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Prefoldin_2 PF01920.20 PIK45934.1 - 8.7e-18 64.2 2.0 1.1e-17 63.9 2.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Med9 PF07544.13 PIK45934.1 - 0.0011 19.0 1.9 0.0018 18.3 1.9 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 OmpH PF03938.14 PIK45934.1 - 0.0012 19.1 0.4 0.0016 18.8 0.4 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Prefoldin PF02996.17 PIK45934.1 - 0.0031 17.4 0.5 0.0041 17.0 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit DegS PF05384.11 PIK45934.1 - 0.027 14.0 1.5 0.032 13.7 1.0 1.4 2 0 0 2 2 2 0 Sensor protein DegS APG6_N PF17675.1 PIK45934.1 - 0.062 13.8 1.8 0.091 13.3 1.8 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region RNA_GG_bind PF10258.9 PIK45934.1 - 0.066 13.3 1.0 0.21 11.6 0.4 1.9 1 1 1 2 2 2 0 PHAX RNA-binding domain Flp1_like PF16982.5 PIK45934.1 - 0.16 11.4 0.6 0.39 10.2 0.6 1.6 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain Homeodomain PF00046.29 PIK45935.1 - 0.17 11.8 3.3 0.41 10.5 3.3 1.6 1 0 0 1 1 1 0 Homeodomain Homeodomain PF00046.29 PIK45936.1 - 1.1e-13 50.9 0.1 1.9e-13 50.0 0.1 1.4 1 0 0 1 1 1 1 Homeodomain WD40 PF00400.32 PIK45937.1 - 5.4e-10 39.7 6.6 0.063 14.2 0.0 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK45937.1 - 8.2e-06 26.0 0.1 0.0046 17.2 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 PIK45938.1 - 1.7e-06 28.0 1.0 0.00086 19.0 1.0 2.6 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Nic96 PF04097.14 PIK45938.1 - 0.038 12.5 0.1 0.23 9.9 0.1 2.0 2 1 0 2 2 2 0 Nup93/Nic96 C2-set_2 PF08205.12 PIK45939.1 - 0.003 17.6 1.8 0.024 14.7 0.0 2.9 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK45939.1 - 0.0071 16.7 1.9 0.17 12.3 0.1 3.1 3 1 1 4 4 4 1 Immunoglobulin C1-set domain Invasin_D3 PF09134.10 PIK45939.1 - 0.027 14.8 0.2 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Invasin, domain 3 Marek_A PF02124.15 PIK45939.1 - 0.04 13.7 0.1 0.48 10.2 0.0 2.3 2 0 0 2 2 2 0 Marek's disease glycoprotein A S-layer PF07752.11 PIK45939.1 - 0.056 12.5 0.2 0.1 11.6 0.2 1.3 1 0 0 1 1 1 0 S-layer protein Ig_3 PF13927.6 PIK45939.1 - 0.54 10.9 4.3 80 3.9 0.1 4.4 4 2 1 5 5 5 0 Immunoglobulin domain Peptidase_S8 PF00082.22 PIK45940.1 - 1.3e-18 67.3 22.0 2.3e-18 66.5 20.3 2.0 2 1 0 2 2 2 1 Subtilase family Ecm29 PF13001.7 PIK45941.1 - 0.011 14.4 0.0 2.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Proteasome stabiliser Capsid_NCLDV PF04451.12 PIK45941.1 - 0.12 12.2 0.0 0.97 9.2 0.0 2.1 2 0 0 2 2 2 0 Large eukaryotic DNA virus major capsid protein Calycin_like PF13944.6 PIK45941.1 - 0.13 12.5 0.1 1.3 9.3 0.2 2.6 2 1 0 2 2 2 0 Calycin-like beta-barrel domain Myb_DNA-bind_4 PF13837.6 PIK45943.1 - 8.7e-09 35.6 0.1 1.5e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain RelA_SpoT PF04607.17 PIK45943.1 - 0.016 15.4 0.1 0.026 14.8 0.1 1.4 1 0 0 1 1 1 0 Region found in RelA / SpoT proteins MADF_DNA_bdg PF10545.9 PIK45943.1 - 0.11 12.8 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like C2-set_2 PF08205.12 PIK45944.1 - 2.2e-06 27.7 1.4 0.0032 17.5 0.1 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK45944.1 - 3.4e-06 27.5 2.6 0.032 14.8 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK45944.1 - 4.8e-05 23.7 2.4 0.0064 16.8 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin C1-set domain I-set PF07679.16 PIK45944.1 - 0.00094 19.2 0.2 0.11 12.6 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain RVT_1 PF00078.27 PIK45946.1 - 3.3e-19 69.3 0.1 7.3e-19 68.2 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK45946.1 - 7.3e-18 64.5 0.0 1.9e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45946.1 - 2.8e-08 34.0 0.0 7e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 PIK45946.1 - 0.0055 16.7 1.5 0.0055 16.7 1.5 2.7 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 PIK45946.1 - 0.011 16.1 0.4 0.011 16.1 0.4 2.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCCH_7 PF18586.1 PIK45946.1 - 0.089 13.1 3.3 0.11 12.9 0.7 2.5 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 zf-CCHC_5 PF14787.6 PIK45946.1 - 2.6 7.8 13.4 0.2 11.4 3.9 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Invasin_D3 PF09134.10 PIK45947.1 - 0.00047 20.4 0.5 0.16 12.3 0.0 2.6 2 1 0 2 2 2 2 Invasin, domain 3 PA-IIL PF07472.11 PIK45947.1 - 0.039 14.3 0.4 6 7.2 0.0 3.0 1 1 2 3 3 3 0 Fucose-binding lectin II (PA-IIL) DUF3678 PF12435.8 PIK45947.1 - 0.18 11.2 0.1 0.18 11.2 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3678) Rota_VP4_MID PF17477.2 PIK45948.1 - 0.034 13.5 0.7 0.048 13.0 0.7 1.2 1 0 0 1 1 1 0 Rotavirus VP4 membrane interaction domain zf-CCHC PF00098.23 PIK45950.1 - 0.0072 16.4 3.3 0.0072 16.4 3.3 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45950.1 - 0.013 15.2 12.1 0.62 9.8 0.4 3.7 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45950.1 - 0.063 13.1 6.9 1.1 9.1 0.3 2.8 2 0 0 2 2 2 0 Zinc knuckle IBR PF01485.21 PIK45950.1 - 2.3 8.5 10.0 0.84 9.9 5.0 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Stimulus_sens_1 PF13756.6 PIK45952.1 - 0.029 15.0 0.4 0.14 12.8 0.3 2.0 1 1 0 1 1 1 0 Stimulus-sensing domain rve PF00665.26 PIK45954.1 - 1.5e-26 92.9 0.0 2.4e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK45954.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 PIK45955.1 - 1.5e-11 44.3 0.1 1.9e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5520 PF17658.1 PIK45955.1 - 0.092 11.8 0.1 0.12 11.4 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) MAM33 PF02330.16 PIK45955.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial glycoprotein zf-CCHC PF00098.23 PIK45956.1 - 0.00016 21.6 22.2 0.021 14.9 0.1 4.4 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45956.1 - 0.0053 16.5 9.4 2.2 8.1 0.2 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK45956.1 - 0.0059 16.3 0.9 0.0059 16.3 0.9 2.7 1 1 1 2 2 2 1 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK45956.1 - 0.19 11.7 17.8 0.35 10.9 2.1 3.9 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK45956.1 - 8.2 6.4 17.8 0.14 12.0 4.4 2.9 3 0 0 3 3 3 0 Zinc knuckle Dimer_Tnp_hAT PF05699.14 PIK45957.1 - 2.3e-06 27.3 0.0 3e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF659 PF04937.15 PIK45958.1 - 0.14 12.1 0.1 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) zf-CCHC PF00098.23 PIK45959.1 - 6.2e-07 29.2 15.8 0.00068 19.6 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK45959.1 - 0.00084 19.1 8.2 0.11 12.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45959.1 - 0.023 14.5 0.2 0.023 14.5 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK45959.1 - 0.023 14.4 0.8 0.023 14.4 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK45959.1 - 0.041 13.6 11.1 5.1 6.9 0.3 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK45959.1 - 0.064 13.2 16.5 0.25 11.3 1.2 3.6 2 1 2 4 4 4 0 Zinc knuckle Caskin1-CID PF16600.5 PIK45960.1 - 0.88 10.2 5.6 2.9 8.5 5.6 1.9 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain zf-CCHC PF00098.23 PIK45962.1 - 2.6e-05 24.1 16.1 0.0034 17.4 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45962.1 - 7.2e-05 22.5 6.2 0.0031 17.3 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45962.1 - 0.00027 20.6 14.2 0.51 10.1 1.1 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK45962.1 - 2 8.7 12.3 0.81 10.0 7.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK45962.1 - 7.1 6.5 12.9 0.94 9.3 0.3 3.8 4 0 0 4 4 4 0 C2H2 zinc-finger zf-CCHC PF00098.23 PIK45963.1 - 0.0059 16.6 0.6 0.0059 16.6 0.6 2.8 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45963.1 - 2.8 7.8 4.5 3 7.7 0.0 2.8 3 0 0 3 3 3 0 Zinc knuckle Dimer_Tnp_hAT PF05699.14 PIK45964.1 - 3.3e-13 49.2 0.1 6.8e-13 48.2 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DDE_Tnp_1_7 PF13843.6 PIK45965.1 - 8.3e-59 199.6 1.0 2e-46 158.9 0.8 2.0 2 0 0 2 2 2 2 Transposase IS4 rve PF00665.26 PIK45966.1 - 3.7e-21 75.5 0.0 1.6e-20 73.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK45966.1 - 4.1e-15 55.9 0.1 1.1e-14 54.5 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK45966.1 - 2.1e-14 53.3 5.3 2.3e-14 53.2 3.8 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK45966.1 - 8.2e-08 32.2 0.6 1.3e-06 28.4 0.1 2.8 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK45966.1 - 0.00027 21.1 5.6 0.017 15.3 4.8 3.2 3 0 0 3 3 3 1 H2C2 zinc finger zf-H3C2 PF16721.5 PIK45966.1 - 0.0013 19.1 0.5 0.0036 17.6 0.1 1.9 2 0 0 2 2 2 1 Zinc-finger like, probable DNA-binding rve_3 PF13683.6 PIK45966.1 - 0.014 15.2 0.0 0.041 13.6 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK45966.1 - 0.015 15.5 0.0 0.031 14.5 0.0 1.5 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK45967.1 - 2.9e-10 40.1 0.0 5.4e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1736 PF08409.11 PIK45969.1 - 0.0063 16.5 23.7 90 3.2 0.1 9.2 1 1 9 10 10 10 0 Domain of unknown function (DUF1736) FAM150 PF15129.6 PIK45969.1 - 0.038 14.2 13.6 41 4.3 0.5 5.2 1 1 6 7 7 7 0 FAM150 family Myf5 PF12232.8 PIK45969.1 - 0.043 14.6 18.8 4.2e+02 1.8 0.0 9.2 11 0 0 11 11 11 0 Myogenic determination factor 5 CBM32 PF18344.1 PIK45970.1 - 3.6e-13 49.1 0.0 94 3.0 0.0 12.3 1 1 15 16 16 16 0 Carbohydrate binding module family 32 VQ PF05678.14 PIK45970.1 - 2.3e-08 33.4 30.2 1.1e+02 2.3 0.0 15.8 17 0 0 17 17 17 0 VQ motif HTH_23 PF13384.6 PIK45972.1 - 3.2e-05 23.6 0.0 0.00011 21.9 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 PIK45972.1 - 0.0049 16.2 0.0 0.073 12.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_18 PF12833.7 PIK45972.1 - 0.0066 16.7 0.2 1.4 9.3 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 PIK45972.1 - 0.0079 16.4 0.5 6.6 7.1 0.0 2.7 2 1 0 2 2 2 2 Transposase HTH_11 PF08279.12 PIK45972.1 - 0.0084 16.0 0.0 0.021 14.7 0.0 1.7 1 0 0 1 1 1 1 HTH domain HTH_28 PF13518.6 PIK45972.1 - 0.011 15.8 0.0 0.056 13.6 0.0 2.2 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 PIK45972.1 - 0.027 14.3 0.0 0.12 12.3 0.0 2.2 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Sigma70_r4_2 PF08281.12 PIK45972.1 - 0.032 13.9 0.1 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_24 PF13412.6 PIK45972.1 - 0.033 13.8 0.0 0.08 12.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_30 PF13556.6 PIK45972.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_Crp_2 PF13545.6 PIK45972.1 - 0.077 13.0 1.5 0.17 11.9 0.0 2.5 3 2 0 3 3 3 0 Crp-like helix-turn-helix domain HECT PF00632.25 PIK45973.1 - 1.5e-05 24.7 0.0 0.00022 20.9 0.0 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) HSBP1 PF06825.12 PIK45974.1 - 0.021 14.6 2.3 0.042 13.7 0.6 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Retrotran_gag_2 PF14223.6 PIK45974.1 - 0.054 13.2 0.1 0.24 11.1 0.0 2.1 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type Snapin_Pallidin PF14712.6 PIK45974.1 - 0.073 13.5 2.6 0.94 9.9 0.6 2.8 2 0 0 2 2 2 0 Snapin/Pallidin MutS_IV PF05190.18 PIK45974.1 - 0.097 13.0 0.4 1.3 9.4 0.1 2.8 3 0 0 3 3 3 0 MutS family domain IV YebO PF13974.6 PIK45974.1 - 0.33 11.0 3.9 18 5.5 0.0 2.9 3 0 0 3 3 3 0 YebO-like protein RVT_1 PF00078.27 PIK45975.1 - 2e-29 102.7 0.0 3.9e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK45975.1 - 5.2e-29 100.2 0.0 1e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45975.1 - 2.3e-23 82.5 0.0 4.8e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK45976.1 - 9.6e-25 87.1 0.0 1.6e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK45976.1 - 6.8e-23 80.5 0.7 1.4e-22 79.5 0.7 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK45976.1 - 8.5e-05 22.3 0.1 0.0002 21.1 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK45976.1 - 0.0027 17.9 0.3 0.0081 16.4 0.3 1.9 1 0 0 1 1 1 1 H2C2 zinc finger Cnd1 PF12717.7 PIK45977.1 - 0.041 13.9 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 RT_RNaseH_2 PF17919.1 PIK45978.1 - 1.9e-34 117.7 0.0 2.7e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK45978.1 - 2.2e-27 95.4 0.0 3.5e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 PIK45979.1 - 1.8e-05 24.6 16.1 0.0032 17.5 3.3 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK45979.1 - 4.9e-05 23.1 6.2 0.0029 17.4 0.2 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK45979.1 - 0.00017 21.2 14.2 0.48 10.2 1.1 3.7 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK45979.1 - 1.5 9.1 12.3 0.53 10.6 6.8 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK45979.1 - 5.1 6.9 12.9 0.88 9.4 0.3 4.0 4 0 0 4 4 4 0 C2H2 zinc-finger SAM_1 PF00536.30 PIK45980.1 - 1.4e-14 54.3 0.1 4.7e-14 52.6 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK45980.1 - 2.3e-12 46.8 0.0 2e-11 43.8 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) GOLD_2 PF13897.6 PIK45981.1 - 2.2e-46 157.8 1.4 2.2e-46 157.8 1.4 2.5 3 0 0 3 3 3 1 Golgi-dynamics membrane-trafficking ACBP PF00887.19 PIK45981.1 - 3.1e-09 36.9 0.0 7.3e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein U79_P34 PF03064.16 PIK45981.1 - 0.01 15.2 7.2 0.02 14.2 7.2 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MAP7 PF05672.11 PIK45981.1 - 0.012 15.3 28.0 0.028 14.1 28.0 1.5 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Casc1_N PF15927.5 PIK45981.1 - 0.067 12.9 22.8 0.14 11.8 22.8 1.5 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus GvpL_GvpF PF06386.11 PIK45981.1 - 0.27 11.1 7.4 0.45 10.4 7.4 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF TMEM247 PF15444.6 PIK45981.1 - 1.7 8.7 9.7 3.1 7.8 9.7 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 AAA_23 PF13476.6 PIK45981.1 - 2.4 8.6 9.4 3.9 7.9 9.4 1.4 1 0 0 1 1 1 0 AAA domain FmdE PF02663.14 PIK45981.1 - 3.3 7.8 5.5 48 4.0 2.9 2.4 1 1 1 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon PIH1_CS PF18201.1 PIK45982.1 - 3.2e-28 98.0 0.0 1.7e-27 95.7 0.0 2.2 2 0 0 2 2 2 1 PIH1 CS-like domain PIH1 PF08190.12 PIK45982.1 - 1.9e-19 69.8 1.0 1.2e-18 67.1 0.4 2.5 2 0 0 2 2 2 1 PIH1 N-terminal domain RT_RNaseH PF17917.1 PIK45983.1 - 2.7e-31 108.0 0.0 5.4e-31 107.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK45983.1 - 5.7e-22 77.6 0.0 1.3e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK45983.1 - 3e-13 49.8 0.1 4.8e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK45984.1 - 3.4e-20 71.9 0.0 4.9e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK45984.1 - 0.00013 22.1 0.0 0.00013 22.1 0.0 2.0 3 0 0 3 3 3 1 H2C2 zinc finger Laminin_EGF PF00053.24 PIK45986.1 - 2.8e-25 88.2 239.9 0.0013 18.8 11.2 13.5 3 3 10 13 13 13 12 Laminin EGF domain hEGF PF12661.7 PIK45986.1 - 5e-05 23.8 39.8 0.00086 19.9 3.3 17.0 17 3 1 18 18 18 9 Human growth factor-like EGF EGF_2 PF07974.13 PIK45986.1 - 0.0049 17.2 15.8 0.0049 17.2 15.8 17.2 11 9 1 12 12 12 7 EGF-like domain Laminin_EGF PF00053.24 PIK45987.1 - 2.6e-26 91.5 235.8 0.036 14.2 18.3 13.6 4 3 9 13 13 13 11 Laminin EGF domain hEGF PF12661.7 PIK45987.1 - 1.1e-05 25.9 61.2 0.0055 17.3 6.2 18.2 16 4 3 19 19 19 10 Human growth factor-like EGF EGF PF00008.27 PIK45987.1 - 0.025 14.9 11.1 0.025 14.9 11.1 16.8 16 4 0 16 16 16 0 EGF-like domain EGF_2 PF07974.13 PIK45987.1 - 2.4 8.6 273.4 0.036 14.4 17.6 21.2 14 11 2 16 16 16 0 EGF-like domain Laminin_EGF PF00053.24 PIK45988.1 - 1.7e-37 127.3 285.8 0.0015 18.6 19.6 16.5 4 2 12 16 16 16 13 Laminin EGF domain hEGF PF12661.7 PIK45988.1 - 0.00029 21.3 36.1 0.0029 18.2 6.4 21.3 22 3 1 23 23 23 12 Human growth factor-like EGF EGF_2 PF07974.13 PIK45988.1 - 0.011 16.0 12.0 0.011 16.0 12.0 24.8 18 9 3 21 21 21 0 EGF-like domain EphA2_TM PF14575.6 PIK45988.1 - 0.027 15.4 0.0 0.056 14.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain YajC PF02699.15 PIK45988.1 - 0.12 12.2 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit DUF5385 PF17359.2 PIK45988.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Adaptin_N PF01602.20 PIK45989.1 - 2.4e-82 277.2 16.1 3.3e-82 276.8 16.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.6 PIK45989.1 - 3.6e-16 59.3 0.0 1.2e-15 57.6 0.0 2.0 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 PIK45989.1 - 3.7e-13 49.8 1.6 5.8e-09 36.2 0.0 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 PIK45989.1 - 1.6e-06 27.8 0.1 0.25 11.7 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 PIK45989.1 - 2.2e-05 24.8 0.0 1.3 9.4 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 PIK45989.1 - 0.0002 21.8 0.1 2.4 8.8 0.0 4.6 4 1 1 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK45989.1 - 0.013 16.1 0.7 11 6.7 0.0 4.2 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region Glyco_hydro_18 PF00704.28 PIK45990.1 - 5.4e-21 75.6 0.0 6.7e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 TMEM169 PF15052.6 PIK45991.1 - 4.1e-45 153.1 6.8 5e-45 152.8 6.8 1.0 1 0 0 1 1 1 1 TMEM169 protein family Ephrin_rec_like PF07699.13 PIK45992.1 - 0.00012 21.8 26.3 0.014 15.2 2.5 4.5 3 1 1 4 4 4 3 Putative ephrin-receptor like LRR_8 PF13855.6 PIK45992.1 - 0.00099 18.8 1.6 0.053 13.3 0.0 2.5 2 0 0 2 2 2 2 Leucine rich repeat SLATT_5 PF18160.1 PIK45992.1 - 0.22 10.8 4.2 0.25 10.6 1.0 2.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 NCD3G PF07562.14 PIK45993.1 - 0.0082 16.1 1.8 0.0082 16.1 1.8 4.5 3 1 1 4 4 4 2 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 PIK45993.1 - 0.19 11.5 32.3 0.033 14.0 5.6 4.3 3 2 1 4 4 4 0 Putative ephrin-receptor like SLATT_5 PF18160.1 PIK45993.1 - 0.24 10.7 6.7 0.029 13.7 0.8 2.6 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 TRP PF06011.12 PIK45993.1 - 0.27 9.9 12.6 0.1 11.3 3.5 2.8 2 1 1 3 3 3 0 Transient receptor potential (TRP) ion channel Syndecan PF01034.20 PIK45993.1 - 2.7 8.0 0.0 2.7 8.0 0.0 3.2 4 0 0 4 4 4 0 Syndecan domain Lyase_aromatic PF00221.19 PIK45994.1 - 4.9e-183 609.0 0.1 5.8e-183 608.8 0.1 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase RVT_1 PF00078.27 PIK45995.1 - 0.0058 16.2 0.1 0.014 14.9 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MTS PF05175.14 PIK45995.1 - 0.023 14.2 0.2 0.051 13.1 0.2 1.5 1 0 0 1 1 1 0 Methyltransferase small domain TraB PF01963.17 PIK45996.1 - 4.6e-29 102.1 0.0 6.1e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 TraB family EB PF01683.18 PIK45997.1 - 0.00017 21.8 2.2 0.00034 20.8 2.2 1.5 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 PIK45997.1 - 0.00062 20.1 11.6 0.0015 18.8 11.5 1.7 1 1 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK45997.1 - 0.019 15.6 8.0 0.019 15.6 8.0 2.9 3 0 0 3 3 3 0 Human growth factor-like EGF I-EGF_1 PF18372.1 PIK45997.1 - 0.11 12.7 7.6 0.28 11.3 7.6 1.8 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 PIK45997.1 - 0.48 10.5 6.2 1.1 9.4 5.7 1.9 1 1 1 2 2 2 0 Tenascin EGF domain BNR PF02012.20 PIK45998.1 - 3.4e-14 50.5 30.4 1.7 8.9 0.1 12.0 11 0 0 11 11 11 6 BNR/Asp-box repeat EGF_2 PF07974.13 PIK45998.1 - 7.1e-14 51.9 121.9 0.0067 16.8 14.1 8.0 7 0 0 7 7 7 6 EGF-like domain EGF_Tenascin PF18720.1 PIK45998.1 - 0.0019 18.2 87.2 0.21 11.7 5.0 7.5 7 0 0 7 7 7 6 Tenascin EGF domain EB PF01683.18 PIK45998.1 - 0.0023 18.2 54.8 0.093 13.0 2.8 6.9 6 0 0 6 6 6 5 EB module Reeler PF02014.16 PIK45998.1 - 0.0089 16.8 0.0 0.031 15.0 0.0 2.0 1 0 0 1 1 1 1 Reeler domain hEGF PF12661.7 PIK45998.1 - 0.034 14.8 96.2 0.11 13.2 7.1 8.4 9 0 0 9 9 9 0 Human growth factor-like EGF EGF PF00008.27 PIK45998.1 - 0.5 10.7 103.3 0.11 12.8 12.8 7.5 7 0 0 7 7 7 0 EGF-like domain ORC5_C PF14630.6 PIK45999.1 - 1.9e-67 227.8 1.8 2.4e-67 227.4 1.8 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 PIK45999.1 - 6.4e-09 36.4 0.0 1.7e-08 35.0 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK45999.1 - 2.8e-07 30.9 0.0 7.4e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 PIK45999.1 - 0.054 13.9 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 PIK45999.1 - 0.11 12.2 0.0 2.8 7.6 0.1 2.7 1 1 1 2 2 2 0 AAA domain 7tm_1 PF00001.21 PIK46000.1 - 2.5e-27 95.9 13.8 3.3e-27 95.5 13.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46000.1 - 3.7e-08 33.3 15.8 3.7e-08 33.3 15.8 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx RCR PF12273.8 PIK46000.1 - 0.099 13.3 3.3 0.68 10.6 0.1 3.0 2 1 1 3 3 3 0 Chitin synthesis regulation, resistance to Congo red 7tm_4 PF13853.6 PIK46000.1 - 0.84 9.3 11.8 0.041 13.6 1.5 3.0 3 1 1 4 4 4 0 Olfactory receptor GTSE1_N PF15259.6 PIK46002.1 - 3.9e-23 82.2 10.7 3.5e-16 59.7 1.7 2.6 1 1 1 2 2 2 2 G-2 and S-phase expressed 1 TFIIE-A_C PF11521.8 PIK46002.1 - 0.097 13.0 3.1 0.17 12.2 3.1 1.5 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha UPF0239 PF06783.11 PIK46003.1 - 2e-12 47.1 0.0 2.3e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0239) SKICH PF17751.1 PIK46004.1 - 5.7e-17 62.2 0.4 5.7e-17 62.2 0.4 2.7 2 0 0 2 2 2 1 SKICH domain DUF5082 PF16888.5 PIK46004.1 - 0.00024 21.4 11.6 0.00024 21.4 11.6 5.6 2 1 3 5 5 5 1 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 PIK46004.1 - 0.0066 16.7 11.8 0.0066 16.7 11.8 6.6 2 2 1 5 5 5 2 TATA element modulatory factor 1 TATA binding GAS PF13851.6 PIK46004.1 - 0.0095 15.3 6.3 0.0095 15.3 6.3 5.4 2 1 2 5 5 5 2 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK46004.1 - 0.23 10.3 96.6 0.07 12.0 20.7 4.5 2 1 3 5 5 5 0 Spc7 kinetochore protein zf-C2H2_4 PF13894.6 PIK46005.1 - 0.00036 21.1 14.9 0.8 10.7 0.4 3.7 3 1 0 3 3 3 3 C2H2-type zinc finger DZR PF12773.7 PIK46005.1 - 0.067 13.2 2.6 0.9 9.6 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-Di19 PF05605.12 PIK46005.1 - 0.1 12.9 8.9 0.12 12.7 4.4 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK46005.1 - 0.13 12.7 10.3 0.81 10.2 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zinc_ribbon_15 PF17032.5 PIK46005.1 - 0.2 12.4 5.4 0.7 10.7 1.8 2.2 1 1 2 3 3 3 0 zinc-ribbon family zf-U1 PF06220.12 PIK46005.1 - 0.23 11.3 0.3 0.23 11.3 0.3 2.2 3 0 0 3 3 3 0 U1 zinc finger zf-C2H2 PF00096.26 PIK46005.1 - 0.27 11.8 0.3 0.27 11.8 0.3 4.6 3 2 0 3 3 3 0 Zinc finger, C2H2 type zf-C4 PF00105.18 PIK46005.1 - 1.9 9.0 5.2 2.2 8.8 1.9 2.1 1 1 1 2 2 2 0 Zinc finger, C4 type (two domains) OrfB_Zn_ribbon PF07282.11 PIK46005.1 - 8.7 6.3 6.5 4.1 7.4 3.4 2.1 2 1 0 2 2 2 0 Putative transposase DNA-binding domain TPR_19 PF14559.6 PIK46006.1 - 2.7e-15 56.6 1.3 0.00014 22.3 0.0 4.5 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK46006.1 - 3.4e-13 48.6 2.6 0.012 15.7 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46006.1 - 5.5e-10 39.2 0.0 0.016 16.0 0.0 6.0 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46006.1 - 7.4e-08 31.9 7.0 0.086 12.7 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK46006.1 - 6.4e-07 29.6 0.2 0.57 10.5 0.2 4.7 5 2 1 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK46006.1 - 1.7e-06 28.2 3.9 0.036 14.3 0.4 3.5 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 PIK46006.1 - 3.3e-06 27.1 8.2 0.19 12.1 1.1 5.4 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 PIK46006.1 - 6.8e-06 26.3 0.2 2.8 8.3 0.0 4.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK46006.1 - 0.0005 20.5 5.2 0.72 10.6 0.1 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46006.1 - 0.0011 19.0 0.1 0.0011 19.0 0.1 3.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK46006.1 - 0.0058 16.1 0.0 0.081 12.3 0.0 2.6 2 1 0 2 2 2 1 MalT-like TPR region PPR PF01535.20 PIK46006.1 - 0.0075 16.5 0.8 6.1 7.3 0.0 4.1 4 0 0 4 4 4 1 PPR repeat Fis1_TPR_C PF14853.6 PIK46006.1 - 0.016 15.2 0.6 6.7 6.9 0.1 3.0 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 PIK46006.1 - 0.042 13.9 0.3 0.64 10.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK46006.1 - 0.064 13.0 3.4 0.86 9.3 0.1 3.3 2 1 1 3 3 3 0 TPR repeat TPR_10 PF13374.6 PIK46006.1 - 0.071 13.0 0.1 23 5.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK46007.1 - 9.4e-21 74.1 16.7 1.5e-07 31.8 1.5 7.1 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK46007.1 - 7.9e-16 56.8 6.6 0.12 12.5 0.0 8.4 10 0 0 10 10 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK46007.1 - 5.8e-15 55.7 0.3 0.013 16.2 0.0 6.8 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46007.1 - 8.6e-14 51.1 8.5 0.0087 16.8 0.1 9.1 4 2 7 11 11 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46007.1 - 1.3e-13 50.2 4.7 0.077 12.9 0.0 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK46007.1 - 4.8e-13 48.5 0.6 0.0015 18.8 0.3 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK46007.1 - 9.1e-13 48.3 6.5 0.00015 21.9 0.1 6.2 4 3 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 PIK46007.1 - 2.8e-12 45.8 6.8 0.0095 16.1 0.0 6.8 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK46007.1 - 1.5e-10 41.2 11.1 0.019 15.3 0.7 7.8 5 3 2 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK46007.1 - 1.8e-10 40.3 3.5 0.0005 19.7 0.2 4.8 4 1 0 4 4 4 3 TPR repeat TPR_6 PF13174.6 PIK46007.1 - 6.2e-08 32.8 13.2 0.035 14.8 0.1 8.7 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK46007.1 - 2.6e-07 30.7 2.9 0.005 17.0 0.1 4.9 4 1 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK46007.1 - 1.9e-06 27.1 0.7 0.23 10.3 0.0 3.8 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 Coatomer_E PF04733.14 PIK46007.1 - 0.00015 21.3 5.6 0.045 13.2 1.2 4.3 3 1 0 3 3 3 1 Coatomer epsilon subunit TPR_20 PF14561.6 PIK46007.1 - 0.0079 16.5 4.7 54 4.2 0.2 5.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK46007.1 - 0.009 15.4 9.6 1.7 7.9 0.0 4.2 2 1 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 PIK46007.1 - 0.024 15.2 11.5 2.1 9.2 0.0 6.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK46007.1 - 0.027 14.5 7.8 4.4 7.6 0.1 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK46007.1 - 0.062 13.2 8.9 1.8 8.5 0.0 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat TPPII_N PF12583.8 PIK46007.1 - 0.075 13.6 0.1 13 6.3 0.0 2.5 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal AP_endonuc_2 PF01261.24 PIK46007.1 - 0.11 12.0 0.0 7.9 5.9 0.0 2.6 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel RT_RNaseH PF17917.1 PIK46008.1 - 1.9e-38 130.9 0.0 5e-38 129.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46008.1 - 3.3e-37 126.5 0.0 7.6e-37 125.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46008.1 - 1.7e-28 99.7 0.0 2.9e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46008.1 - 1.7e-23 83.0 0.0 3.4e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46008.1 - 2.6e-18 65.9 0.1 5.7e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46008.1 - 2.5e-05 24.0 0.2 7.3e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK46008.1 - 8.5e-05 22.7 0.0 0.0003 20.9 0.0 2.0 1 0 0 1 1 1 1 H2C2 zinc finger LMBR1 PF04791.16 PIK46010.1 - 2.6e-21 76.2 2.2 8.9e-17 61.2 0.0 2.1 1 1 1 2 2 2 2 LMBR1-like membrane protein TssO PF17561.2 PIK46010.1 - 0.69 10.0 0.0 0.69 10.0 0.0 3.3 4 0 0 4 4 4 0 Type VI secretion system, TssO DUF2615 PF11027.8 PIK46010.1 - 2.9 8.1 7.4 2 8.6 0.3 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2615) Ribosomal_L27A PF00828.19 PIK46011.1 - 2.8e-19 70.1 0.0 4.5e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Neur_chan_memb PF02932.16 PIK46013.1 - 9.4e-18 65.1 8.0 2.1e-17 64.0 3.4 2.4 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK46013.1 - 7.6e-06 25.5 0.0 0.054 12.9 0.0 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK46014.1 - 2.8e-19 70.1 6.7 6.4e-17 62.4 2.2 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK46014.1 - 2.1e-08 33.9 0.1 3.7e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Pex24p PF06398.11 PIK46014.1 - 0.14 11.1 0.1 0.14 11.1 0.1 1.9 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin Neur_chan_LBD PF02931.23 PIK46015.1 - 4.5e-30 104.7 0.2 5.8e-30 104.4 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK46015.1 - 1.9e-07 31.4 0.0 2.6e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DNA_pol_E_B PF04042.16 PIK46017.1 - 1.6e-42 145.2 0.1 2.3e-42 144.7 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 PIK46017.1 - 1.8e-08 34.6 0.4 1.5e-05 25.1 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase alpha subunit B N-terminal HOOK PF05622.12 PIK46018.1 - 1e-06 27.3 39.6 3.8e-06 25.4 20.1 4.8 2 2 4 6 6 6 3 HOOK protein Tropomyosin_1 PF12718.7 PIK46018.1 - 0.0084 16.3 3.3 0.0084 16.3 3.3 7.7 5 2 1 7 7 7 4 Tropomyosin like DUF4144 PF13642.6 PIK46018.1 - 0.94 10.1 6.1 0.76 10.4 0.1 3.5 3 1 0 3 3 3 0 protein structure with unknown function Patched PF02460.18 PIK46018.1 - 1.5 6.8 6.7 0.36 8.9 0.3 2.2 2 0 0 2 2 2 0 Patched family BCL9 PF11502.8 PIK46018.1 - 2.9 7.8 11.1 3 7.7 2.7 3.0 2 0 0 2 2 2 0 B-cell lymphoma 9 protein COX7a PF02238.15 PIK46019.1 - 7.4e-07 29.5 0.3 7.4e-07 29.5 0.3 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase subunit VII COX7a PF02238.15 PIK46020.1 - 3.2e-05 24.2 0.0 4.1e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Ank_2 PF12796.7 PIK46021.1 - 4.1e-35 120.2 8.2 1.6e-11 44.6 0.2 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK46021.1 - 2.3e-31 107.8 0.4 6.9e-10 39.3 0.0 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46021.1 - 3.6e-23 79.1 1.0 0.00032 20.9 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 PIK46021.1 - 3.2e-18 65.3 3.3 0.0029 18.0 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 PIK46021.1 - 2.7e-17 62.6 2.2 7.5e-05 22.9 0.0 5.2 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK46022.1 - 1.8e-35 121.4 0.0 2.3e-16 60.1 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK46022.1 - 2e-33 114.4 1.7 6.3e-14 52.2 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK46022.1 - 1.3e-27 95.5 0.8 2.5e-11 43.6 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46022.1 - 1.1e-22 77.7 0.0 1.4e-07 31.2 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 PIK46022.1 - 1.3e-21 76.0 0.0 2.9e-06 27.5 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Menin PF05053.13 PIK46023.1 - 1.9e-61 208.3 0.6 8.2e-52 176.5 0.1 2.0 2 0 0 2 2 2 2 Menin Menin PF05053.13 PIK46024.1 - 7.8e-99 331.9 0.0 9.8e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 Menin DUF499 PF04465.12 PIK46024.1 - 0.0099 13.7 0.0 0.013 13.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF499) E1_DerP2_DerF2 PF02221.15 PIK46025.1 - 5.5e-20 72.2 4.9 7.5e-20 71.7 4.9 1.1 1 0 0 1 1 1 1 ML domain PDDEXK_10 PF07788.11 PIK46025.1 - 0.055 13.4 0.9 0.096 12.6 0.9 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Ion_trans PF00520.31 PIK46026.1 - 2.6e-48 164.4 61.7 8.5e-34 116.9 26.5 2.2 2 0 0 2 2 2 2 Ion transport protein EF-hand_7 PF13499.6 PIK46027.1 - 2.6e-05 24.6 0.1 0.45 11.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair DUF5580 PF17743.1 PIK46027.1 - 3e-05 22.8 7.6 0.0022 16.6 0.1 3.4 3 0 0 3 3 3 2 Family of unknown function (DUF5580) EF-hand_6 PF13405.6 PIK46027.1 - 0.0029 17.4 0.0 5.4 7.2 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK46027.1 - 0.1 12.2 0.0 13 5.6 0.0 3.2 3 0 0 3 3 3 0 EF hand TPR_2 PF07719.17 PIK46028.1 - 2.1e-24 83.6 0.5 0.023 14.8 0.0 11.0 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46028.1 - 3.3e-20 70.6 0.3 0.037 14.3 0.0 9.4 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK46028.1 - 7.8e-20 71.2 4.5 0.026 15.0 0.0 7.4 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46028.1 - 9.5e-19 66.4 0.7 0.0026 17.5 0.0 9.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46028.1 - 4.1e-18 64.5 2.1 0.002 18.8 0.0 10.5 7 2 5 12 12 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK46028.1 - 1.2e-17 64.2 0.0 0.00024 21.7 0.0 7.6 8 1 1 9 9 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 PIK46028.1 - 1.9e-12 47.2 0.7 0.00031 20.8 0.0 6.2 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK46028.1 - 3.7e-10 39.3 0.0 0.032 13.9 0.0 6.4 5 1 2 7 7 7 2 TPR repeat TPR_17 PF13431.6 PIK46028.1 - 7.1e-10 38.6 12.2 0.0036 17.6 0.0 7.5 10 0 0 10 10 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK46028.1 - 3.2e-07 29.9 8.1 0.5 10.5 0.0 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK46028.1 - 3.7e-07 30.3 18.7 0.00086 19.5 0.1 6.2 4 3 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 PIK46028.1 - 1.7e-06 28.2 18.0 0.0087 16.3 0.1 7.9 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK46028.1 - 0.00012 22.5 7.0 61 4.6 0.0 8.3 11 0 0 11 11 10 0 Tetratricopeptide repeat TPR_20 PF14561.6 PIK46028.1 - 0.00063 20.0 1.0 0.39 11.1 0.0 4.1 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK46028.1 - 0.0029 17.3 0.6 15 5.2 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 PIK46028.1 - 0.012 15.6 0.1 25 5.0 0.0 4.7 3 1 1 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 PIK46028.1 - 0.013 14.5 0.6 1 8.3 0.0 2.8 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_E PF04733.14 PIK46028.1 - 0.015 14.8 1.1 3.5 6.9 0.1 3.5 3 0 0 3 3 3 0 Coatomer epsilon subunit ANAPC5 PF12862.7 PIK46028.1 - 0.037 14.1 1.1 3 8.0 0.0 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.14 PIK46028.1 - 0.093 13.4 4.0 14 6.7 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK46028.1 - 7.7 6.5 7.1 30 4.7 0.0 5.2 7 0 0 7 7 6 0 Tetratricopeptide repeat Collagen PF01391.18 PIK46029.1 - 0.0039 16.9 3.9 0.0039 16.9 3.9 1.8 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) zf-CCHC_2 PF13696.6 PIK46030.1 - 9.8e-05 22.1 5.9 0.00022 21.0 5.9 1.6 1 0 0 1 1 1 1 Zinc knuckle PNMA PF14893.6 PIK46030.1 - 0.0037 16.7 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC_3 PF13917.6 PIK46030.1 - 0.0041 17.0 1.7 0.0078 16.2 1.7 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 PIK46030.1 - 0.007 16.8 0.4 0.015 15.7 0.4 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.23 PIK46030.1 - 0.029 14.5 5.8 0.044 13.9 5.8 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK46030.1 - 0.085 12.6 3.8 0.18 11.5 3.8 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Fez1 PF06818.15 PIK46030.1 - 0.16 12.4 1.4 8.2 6.8 0.1 2.6 2 1 0 2 2 2 0 Fez1 DUF2717 PF10911.8 PIK46030.1 - 0.17 11.6 0.0 0.49 10.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) RT_RNaseH_2 PF17919.1 PIK46031.1 - 3.5e-29 100.8 0.0 6.9e-29 99.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46031.1 - 4.1e-26 91.3 0.0 1.1e-25 89.9 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK46031.1 - 6.5e-23 81.2 0.0 1.6e-22 79.9 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46031.1 - 1.2e-19 70.2 1.8 3.9e-19 68.5 1.8 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK46031.1 - 2.7e-14 53.3 0.1 3.8e-07 29.9 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK46031.1 - 0.00026 21.1 1.0 0.0012 19.0 0.9 2.1 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK46031.1 - 0.0067 16.2 0.1 0.023 14.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain SprT-like PF10263.9 PIK46031.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 SprT-like family Collagen PF01391.18 PIK46032.1 - 8.6e-06 25.4 15.6 0.014 15.2 3.9 2.5 2 0 0 2 2 2 2 Collagen triple helix repeat (20 copies) DUF1157 PF06636.11 PIK46032.1 - 0.00043 19.2 0.0 0.64 8.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1157) Vasohibin PF14822.6 PIK46032.1 - 0.073 12.3 0.0 9.7 5.3 0.0 2.1 2 0 0 2 2 2 0 Vasohibin Collagen PF01391.18 PIK46033.1 - 0.0011 18.6 5.4 0.0012 18.6 3.9 1.6 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) NPL PF17800.1 PIK46034.1 - 9.2e-18 64.7 0.4 3e-17 63.1 0.0 2.0 2 0 0 2 2 2 1 Nucleoplasmin-like domain HMG_box PF00505.19 PIK46035.1 - 1.4e-19 70.2 0.2 3.6e-19 68.9 0.2 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK46035.1 - 5.2e-13 49.4 3.9 6e-13 49.2 0.5 2.5 1 1 1 2 2 2 1 HMG-box domain DUF812 PF05667.11 PIK46035.1 - 0.0025 16.8 10.5 0.0035 16.3 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Tho2 PF11262.8 PIK46035.1 - 0.011 15.0 0.4 0.011 15.0 0.4 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 BST2 PF16716.5 PIK46035.1 - 0.019 15.5 2.1 0.019 15.5 2.1 2.1 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 Protamine_like PF06382.11 PIK46035.1 - 0.022 15.0 0.3 0.038 14.2 0.3 1.4 1 0 0 1 1 1 0 Protamine and protamine like COG5 PF10392.9 PIK46035.1 - 0.026 14.7 2.4 0.048 13.8 2.4 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Jnk-SapK_ap_N PF09744.9 PIK46035.1 - 1.4 9.1 14.0 0.057 13.6 3.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1043 PF06295.12 PIK46035.1 - 1.4 8.9 8.3 0.063 13.3 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF16 PF01519.16 PIK46035.1 - 1.6 9.2 9.7 0.08 13.4 2.7 2.3 3 0 0 3 3 2 0 Protein of unknown function DUF16 SOGA PF11365.8 PIK46035.1 - 1.7 9.8 12.5 0.2 12.8 5.0 2.3 2 0 0 2 2 2 0 Protein SOGA TMCO5 PF14992.6 PIK46035.1 - 3.3 7.2 13.9 0.081 12.5 6.4 1.8 2 0 0 2 2 2 0 TMCO5 family DUF4763 PF15960.5 PIK46035.1 - 3.4 6.9 13.2 9.9 5.4 13.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) TssO PF17561.2 PIK46035.1 - 4.9 7.2 9.3 6 7.0 3.2 2.3 2 0 0 2 2 2 0 Type VI secretion system, TssO YABBY PF04690.13 PIK46035.1 - 7.3 7.1 6.8 1.2 9.7 0.1 2.5 2 1 1 3 3 3 0 YABBY protein TMPIT PF07851.13 PIK46035.1 - 8.4 5.5 7.1 0.65 9.2 1.3 1.8 2 0 0 2 2 2 0 TMPIT-like protein LRR_6 PF13516.6 PIK46036.1 - 3.8e-11 42.1 17.5 0.028 14.5 0.0 5.7 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 PIK46036.1 - 0.03 14.7 14.1 4.1 8.0 1.7 5.4 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) DNApol_Exo PF18136.1 PIK46036.1 - 0.49 9.5 2.8 0.84 8.7 2.8 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Sulfotransfer_1 PF00685.27 PIK46037.1 - 3.7e-11 43.0 2.6 2.3e-09 37.1 2.6 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK46037.1 - 1.3e-08 35.5 0.1 8.7e-06 26.3 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase family Acyl-CoA_dh_1 PF00441.24 PIK46038.1 - 1.3e-37 129.3 0.1 1.9e-37 128.8 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46038.1 - 1.9e-28 98.5 0.0 3.5e-28 97.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK46038.1 - 1.8e-20 73.7 0.1 4.2e-20 72.5 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK46038.1 - 6.4e-07 29.7 0.0 1.2e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Aerolysin PF01117.20 PIK46038.1 - 0.029 13.6 0.0 0.045 13.0 0.0 1.2 1 0 0 1 1 1 0 Aerolysin toxin HpaB_N PF11794.8 PIK46038.1 - 0.049 13.3 1.2 0.063 12.9 0.0 1.9 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 PIK46039.1 - 3.6e-37 127.9 0.1 5e-37 127.4 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46039.1 - 2.2e-28 98.3 0.0 3.9e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK46039.1 - 5.6e-20 72.1 0.2 1.4e-19 70.8 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK46039.1 - 6.4e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Aerolysin PF01117.20 PIK46039.1 - 0.013 14.7 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Aerolysin toxin HpaB_N PF11794.8 PIK46039.1 - 0.15 11.7 0.8 0.44 10.2 0.0 2.1 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 PIK46040.1 - 1.6e-37 129.0 0.2 2.4e-37 128.5 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46040.1 - 2.2e-28 98.3 0.0 4.1e-28 97.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK46040.1 - 7.5e-20 71.7 0.1 1.8e-19 70.4 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK46040.1 - 2e-06 28.1 0.0 4.4e-06 27.0 0.0 1.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Aerolysin PF01117.20 PIK46040.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Aerolysin toxin HpaB_N PF11794.8 PIK46040.1 - 0.12 12.1 1.4 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_N PF02771.16 PIK46042.1 - 3.3e-30 105.1 0.0 5.5e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46042.1 - 2.5e-27 94.9 0.0 5.3e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 PIK46042.1 - 1.3e-17 64.4 0.0 2.3e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK46042.1 - 0.033 14.4 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_1 PF00441.24 PIK46043.1 - 1.1e-41 142.5 0.0 1.6e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK46043.1 - 1.1e-30 106.5 0.0 2.1e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46043.1 - 8.9e-28 96.4 0.0 1.9e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK46043.1 - 1.2e-07 32.0 0.0 3.5e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Sulfotransfer_1 PF00685.27 PIK46044.1 - 8.1e-08 32.1 5.3 1e-06 28.4 5.3 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK46044.1 - 1.8e-05 25.2 0.6 0.00095 19.6 0.2 2.4 1 1 0 2 2 2 1 Sulfotransferase family DUF2645 PF10840.8 PIK46044.1 - 0.039 14.6 0.5 13 6.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2645) MFS_1_like PF12832.7 PIK46045.1 - 2.5e-45 155.0 0.0 3.1e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK46045.1 - 1.5e-12 47.1 0.3 7.4e-07 28.4 0.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 PIK46045.1 - 6.3e-06 25.2 5.2 0.012 14.4 2.2 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter MFS_2 PF13347.6 PIK46045.1 - 0.0003 19.5 1.9 0.31 9.5 0.0 2.1 2 0 0 2 2 2 2 MFS/sugar transport protein Nuc_H_symport PF03825.16 PIK46045.1 - 0.049 12.6 4.4 0.53 9.2 0.2 2.1 2 0 0 2 2 2 0 Nucleoside H+ symporter MFS_1_like PF12832.7 PIK46046.1 - 3.6e-18 65.6 5.8 4.3e-18 65.4 5.8 1.0 1 0 0 1 1 1 1 MFS_1 like family DUF1072 PF06380.11 PIK46046.1 - 0.041 13.7 1.0 0.1 12.5 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1072) CP2 PF04516.15 PIK46047.1 - 3.3e-53 180.3 0.7 4.9e-53 179.8 0.7 1.2 1 0 0 1 1 1 1 CP2 transcription factor SARS_X4 PF08779.10 PIK46047.1 - 0.056 13.6 0.2 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 SARS coronavirus X4 like SH3_9 PF14604.6 PIK46048.1 - 2.1e-13 49.9 0.0 3.4e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Nebulin PF00880.18 PIK46048.1 - 2.3e-13 49.7 1.5 1.8e-05 24.6 0.2 2.3 2 0 0 2 2 2 2 Nebulin repeat SH3_1 PF00018.28 PIK46048.1 - 5.2e-13 48.4 0.0 9.9e-13 47.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain LIM PF00412.22 PIK46048.1 - 1.4e-11 44.5 7.5 2.3e-11 43.7 7.5 1.4 1 0 0 1 1 1 1 LIM domain SH3_2 PF07653.17 PIK46048.1 - 1.1e-06 28.2 0.0 4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Rpn3_C PF08375.11 PIK46049.1 - 6.2e-27 93.8 3.8 6.2e-27 93.8 3.8 2.5 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 PIK46049.1 - 2.6e-11 44.0 3.9 2.9e-08 34.2 0.0 4.0 3 1 1 4 4 4 2 PCI domain TPR_2 PF07719.17 PIK46049.1 - 0.014 15.5 2.5 0.019 15.1 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46049.1 - 0.2 11.5 2.4 0.23 11.3 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NACHT PF05729.12 PIK46050.1 - 2e-10 40.9 0.0 5.7e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK46050.1 - 3.2e-06 27.3 9.5 1.2e-05 25.5 0.0 5.3 6 0 0 6 6 6 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK46050.1 - 0.00039 21.0 0.0 0.002 18.7 0.0 2.3 1 0 0 1 1 1 1 Immunoglobulin domain AAA_25 PF13481.6 PIK46050.1 - 0.0013 18.3 0.0 0.003 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain I-set PF07679.16 PIK46050.1 - 0.0088 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain AAA_29 PF13555.6 PIK46050.1 - 0.019 14.7 0.2 0.044 13.5 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma_reg_N PF13800.6 PIK46050.1 - 0.04 14.2 0.2 0.13 12.5 0.2 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMEM100 PF16311.5 PIK46050.1 - 0.092 12.3 0.2 0.22 11.1 0.2 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 AAA_16 PF13191.6 PIK46050.1 - 0.16 12.4 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_F PF01990.17 PIK46051.1 - 6e-31 106.6 0.0 6.9e-31 106.4 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF5572 PF17733.1 PIK46051.1 - 0.14 12.0 0.1 0.32 10.9 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5572) FA_hydroxylase PF04116.13 PIK46052.1 - 4.8e-12 46.4 6.9 5.4e-12 46.2 6.9 1.0 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily DUF4886 PF16227.5 PIK46052.1 - 0.029 13.6 0.1 0.035 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) Activin_recp PF01064.23 PIK46053.1 - 5e-08 33.9 7.9 6.3e-08 33.6 7.9 1.1 1 0 0 1 1 1 1 Activin types I and II receptor domain ecTbetaR2 PF08917.10 PIK46053.1 - 0.074 13.0 6.8 0.12 12.3 6.8 1.4 1 1 0 1 1 1 0 Transforming growth factor beta receptor 2 ectodomain Toxin_TOLIP PF00087.21 PIK46053.1 - 3.5 8.0 12.7 67 3.8 12.7 2.1 1 1 0 1 1 1 0 Snake toxin and toxin-like protein Pkinase PF00069.25 PIK46054.1 - 1.1e-18 67.6 0.0 2.2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46054.1 - 1.1e-17 64.2 0.0 4.3e-17 62.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK46054.1 - 0.011 15.7 0.2 0.028 14.3 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK46054.1 - 0.016 14.0 2.2 0.064 12.0 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 PIK46054.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Vps16_C PF04840.12 PIK46056.1 - 1.2e-99 333.4 10.4 1.2e-99 333.4 10.4 1.6 2 0 0 2 2 2 1 Vps16, C-terminal region Vps16_N PF04841.13 PIK46056.1 - 3.6e-37 128.1 0.1 5.9e-37 127.4 0.1 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region DUF4443 PF14544.6 PIK46056.1 - 0.058 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4443) Vps16_N PF04841.13 PIK46057.1 - 4.5e-65 220.0 0.0 5.3e-65 219.8 0.0 1.0 1 0 0 1 1 1 1 Vps16, N-terminal region WD40_like PF17005.5 PIK46057.1 - 0.059 12.7 0.1 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 WD40-like domain Ras PF00071.22 PIK46058.1 - 1.6e-51 174.1 0.1 2.1e-51 173.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK46058.1 - 2.6e-35 121.2 0.1 3.6e-35 120.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK46058.1 - 2.2e-12 46.8 0.2 2.7e-12 46.5 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK46058.1 - 1.5e-07 31.5 0.1 2.2e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 PIK46058.1 - 3e-05 24.3 0.0 0.00027 21.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 PIK46058.1 - 0.00056 19.9 0.2 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 PIK46058.1 - 0.0014 18.0 0.1 0.0018 17.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK46058.1 - 0.0017 17.9 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 PIK46058.1 - 0.0029 17.2 0.1 0.0084 15.7 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 PIK46058.1 - 0.0066 16.8 0.0 0.01 16.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 PIK46058.1 - 0.014 15.1 0.2 0.043 13.5 0.2 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK46058.1 - 0.015 15.8 0.1 0.022 15.3 0.1 1.4 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 PIK46058.1 - 0.019 14.7 0.0 0.029 14.1 0.0 1.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 PIK46058.1 - 0.04 13.3 0.0 0.16 11.4 0.0 1.8 1 1 1 2 2 2 0 Bacterial TniB protein AAA_14 PF13173.6 PIK46058.1 - 0.055 13.5 0.1 0.12 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 PIK46058.1 - 0.059 12.9 0.1 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B FAD-SLDH PF12318.8 PIK46058.1 - 0.084 12.9 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase MCM PF00493.23 PIK46058.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_5 PF07728.14 PIK46058.1 - 0.092 12.7 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 PIK46058.1 - 0.1 12.4 0.6 0.2 11.4 0.5 1.5 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 PIK46058.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region VapB_antitoxin PF09957.9 PIK46059.1 - 0.059 13.3 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB Cut8 PF08559.10 PIK46060.1 - 0.0051 16.5 0.4 0.0059 16.3 0.4 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Sulfotransfer_1 PF00685.27 PIK46061.1 - 4.3e-23 82.2 0.0 4.9e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK46061.1 - 5.1e-10 40.1 0.0 1.2e-09 38.8 0.0 1.6 2 0 0 2 2 2 1 Sulfotransferase family DUF4795 PF16043.5 PIK46062.1 - 3.7e-56 190.0 0.5 5e-56 189.6 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) SYCE1 PF15233.6 PIK46062.1 - 0.065 13.3 2.1 0.13 12.3 2.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Atg14 PF10186.9 PIK46062.1 - 0.075 12.1 2.3 0.1 11.6 0.6 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4164 PF13747.6 PIK46062.1 - 0.2 11.9 6.1 0.26 11.6 2.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) BRE1 PF08647.11 PIK46062.1 - 0.33 11.0 5.4 1.7 8.8 5.4 2.1 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase Laminin_II PF06009.12 PIK46063.1 - 4.4e-05 23.5 11.2 0.017 15.1 5.5 2.5 2 0 0 2 2 2 2 Laminin Domain II ABC_tran_CTD PF16326.5 PIK46063.1 - 0.00011 22.3 10.4 0.0062 16.8 2.3 3.6 2 2 1 3 3 3 1 ABC transporter C-terminal domain TMF_TATA_bd PF12325.8 PIK46063.1 - 0.00032 20.9 17.5 0.037 14.2 9.8 3.0 2 1 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 PIK46063.1 - 0.001 18.0 15.6 0.0014 17.6 15.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) FlaC_arch PF05377.11 PIK46063.1 - 0.0017 18.7 17.2 0.53 10.7 0.2 4.4 3 1 1 4 4 4 1 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 PIK46063.1 - 0.0017 18.6 13.4 0.12 12.6 5.9 3.3 2 1 1 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 PIK46063.1 - 0.0018 18.7 9.1 1.2 9.6 0.5 3.3 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein Cast PF10174.9 PIK46063.1 - 0.0028 16.0 14.5 0.0046 15.3 13.7 1.6 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone ATG16 PF08614.11 PIK46063.1 - 0.0029 17.9 14.3 56 3.9 0.7 2.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) LPP PF04728.13 PIK46063.1 - 0.0033 17.8 11.9 7.5 7.0 2.6 4.4 3 1 1 4 4 4 0 Lipoprotein leucine-zipper TMPIT PF07851.13 PIK46063.1 - 0.0039 16.5 6.4 0.0039 16.5 6.4 2.1 1 1 0 2 2 2 1 TMPIT-like protein Seryl_tRNA_N PF02403.22 PIK46063.1 - 0.0045 17.2 18.5 0.0088 16.3 3.8 3.6 1 1 2 3 3 3 1 Seryl-tRNA synthetase N-terminal domain DHR10 PF18595.1 PIK46063.1 - 0.009 16.1 15.6 0.099 12.7 5.4 3.3 3 1 0 3 3 2 1 Designed helical repeat protein 10 domain ZapB PF06005.12 PIK46063.1 - 0.014 15.8 3.1 0.014 15.8 3.1 3.2 1 1 2 3 3 3 0 Cell division protein ZapB SlyX PF04102.12 PIK46063.1 - 0.017 15.7 9.2 5.6 7.7 5.5 3.9 2 1 1 3 3 3 0 SlyX Baculo_PEP_C PF04513.12 PIK46063.1 - 0.017 15.1 7.8 0.075 13.1 4.2 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 PIK46063.1 - 0.02 14.5 11.1 0.11 12.0 3.4 2.2 1 1 0 2 2 2 0 PspA/IM30 family XhlA PF10779.9 PIK46063.1 - 0.021 15.0 11.1 0.099 12.9 0.8 3.9 2 1 2 4 4 4 0 Haemolysin XhlA DUF1664 PF07889.12 PIK46063.1 - 0.021 14.8 14.1 0.25 11.4 6.5 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 PIK46063.1 - 0.022 15.1 16.7 0.52 10.7 3.6 2.5 1 1 1 2 2 2 0 Syntaxin-like protein Spc7 PF08317.11 PIK46063.1 - 0.028 13.3 16.6 0.32 9.8 15.3 2.2 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 PIK46063.1 - 0.029 13.7 3.4 0.15 11.4 3.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lebercilin PF15619.6 PIK46063.1 - 0.036 13.7 18.7 0.51 10.0 6.7 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease FAM76 PF16046.5 PIK46063.1 - 0.037 13.4 11.8 0.054 12.8 11.8 1.2 1 0 0 1 1 1 0 FAM76 protein CLZ PF16526.5 PIK46063.1 - 0.042 14.2 13.4 1.3 9.4 0.1 4.0 2 1 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HOOK PF05622.12 PIK46063.1 - 0.045 11.9 18.1 0.0066 14.7 12.8 1.8 1 1 1 2 2 2 0 HOOK protein SKA1 PF07160.12 PIK46063.1 - 0.049 13.5 15.3 0.012 15.5 9.7 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 IFT57 PF10498.9 PIK46063.1 - 0.053 12.5 17.4 0.098 11.6 17.4 1.5 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 DUF2730 PF10805.8 PIK46063.1 - 0.055 13.6 14.7 0.47 10.6 2.9 3.9 2 1 2 4 4 3 0 Protein of unknown function (DUF2730) CENP-F_leu_zip PF10473.9 PIK46063.1 - 0.055 13.5 20.3 0.023 14.7 12.8 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BST2 PF16716.5 PIK46063.1 - 0.067 13.8 15.1 0.78 10.4 3.1 3.2 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Occludin_ELL PF07303.13 PIK46063.1 - 0.07 13.9 11.9 0.088 13.5 4.3 3.0 1 1 3 4 4 4 0 Occludin homology domain AAA_13 PF13166.6 PIK46063.1 - 0.075 11.7 12.5 0.11 11.2 12.4 1.3 1 1 0 1 1 1 0 AAA domain DUF4988 PF16378.5 PIK46063.1 - 0.075 12.7 7.3 3.5 7.2 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function Prominin PF05478.11 PIK46063.1 - 0.079 10.9 10.0 0.031 12.2 6.6 1.7 1 1 0 1 1 1 0 Prominin MAD PF05557.13 PIK46063.1 - 0.083 11.2 17.0 0.13 10.7 16.9 1.3 1 1 0 1 1 1 0 Mitotic checkpoint protein ApoO PF09769.9 PIK46063.1 - 0.091 12.7 0.8 2.3 8.2 0.1 2.4 2 1 0 2 2 2 0 Apolipoprotein O TPR_MLP1_2 PF07926.12 PIK46063.1 - 0.093 12.8 13.2 0.12 12.4 5.3 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein RmuC PF02646.16 PIK46063.1 - 0.094 11.8 10.3 0.044 12.9 5.1 2.5 1 1 1 2 2 2 0 RmuC family DASH_Dad3 PF08656.10 PIK46063.1 - 0.12 12.5 6.5 4.6 7.4 0.3 3.3 3 0 0 3 3 3 0 DASH complex subunit Dad3 Prefoldin PF02996.17 PIK46063.1 - 0.12 12.3 10.5 0.15 12.0 1.0 3.4 3 1 0 3 3 3 0 Prefoldin subunit MtrG PF04210.13 PIK46063.1 - 0.13 12.1 3.0 10 6.0 0.3 3.4 2 1 2 4 4 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G TMF_DNA_bd PF12329.8 PIK46063.1 - 0.14 12.2 20.6 0.23 11.5 6.3 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding CREPT PF16566.5 PIK46063.1 - 0.19 11.9 13.1 0.28 11.4 7.4 3.0 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2802 PF10975.8 PIK46063.1 - 0.19 11.8 9.3 3.4 7.9 0.2 3.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) End3 PF12761.7 PIK46063.1 - 0.2 11.8 14.0 0.031 14.4 8.5 2.0 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 TolA_bind_tri PF16331.5 PIK46063.1 - 0.21 11.7 20.8 0.39 10.8 0.6 4.0 1 1 3 4 4 4 0 TolA binding protein trimerisation DUF4140 PF13600.6 PIK46063.1 - 0.21 12.0 4.0 12 6.4 0.8 3.0 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) HemX PF04375.14 PIK46063.1 - 0.21 10.8 13.7 0.049 12.9 9.2 1.9 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Sec34 PF04136.15 PIK46063.1 - 0.22 11.4 10.6 0.057 13.3 5.4 2.3 1 1 1 2 2 2 0 Sec34-like family DUF948 PF06103.11 PIK46063.1 - 0.22 11.8 7.5 2.2 8.6 4.8 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 PIK46063.1 - 0.22 11.9 18.0 2.3 8.6 18.0 2.1 1 1 0 1 1 1 0 Fez1 Leu_zip PF15294.6 PIK46063.1 - 0.23 11.0 17.5 0.55 9.7 12.7 2.1 1 1 1 2 2 2 0 Leucine zipper Csm1_N PF18504.1 PIK46063.1 - 0.27 11.6 13.1 0.3 11.4 1.8 3.9 2 1 2 4 4 4 0 Csm1 N-terminal domain ZYG-11_interact PF05884.12 PIK46063.1 - 0.29 10.5 8.1 0.098 12.1 4.6 1.7 1 1 1 2 2 2 0 Interactor of ZYG-11 Snapin_Pallidin PF14712.6 PIK46063.1 - 0.29 11.6 18.5 1.5 9.3 6.7 3.5 3 1 1 4 4 3 0 Snapin/Pallidin DUF4349 PF14257.6 PIK46063.1 - 0.33 10.4 6.5 0.75 9.2 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) FliD_N PF02465.18 PIK46063.1 - 0.36 11.6 15.3 64 4.3 9.9 3.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus T3SSipB PF16535.5 PIK46063.1 - 0.36 11.3 9.2 10 6.6 6.1 2.7 1 1 1 2 2 2 0 Type III cell invasion protein SipB APG6_N PF17675.1 PIK46063.1 - 0.42 11.2 14.9 6.7 7.3 13.5 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region EzrA PF06160.12 PIK46063.1 - 0.42 8.7 13.7 0.16 10.1 9.0 1.9 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Fib_alpha PF08702.10 PIK46063.1 - 0.46 10.7 19.1 1.9 8.7 5.3 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4201 PF13870.6 PIK46063.1 - 0.47 10.2 13.7 1.7 8.3 10.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Phage_GP20 PF06810.11 PIK46063.1 - 0.48 10.2 15.6 0.53 10.1 8.1 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 ATP-synt_D PF01813.17 PIK46063.1 - 0.5 10.2 7.5 0.37 10.6 4.6 2.0 2 1 0 2 2 2 0 ATP synthase subunit D OmpH PF03938.14 PIK46063.1 - 0.51 10.7 15.4 0.095 13.0 7.3 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Bap31_Bap29_C PF18035.1 PIK46063.1 - 0.61 10.1 5.3 0.59 10.2 1.6 2.8 2 1 0 2 2 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain TACC_C PF05010.14 PIK46063.1 - 0.61 9.8 16.4 1.1 8.9 11.1 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal COG2 PF06148.11 PIK46063.1 - 0.62 10.2 13.3 0.2 11.7 8.0 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PI3K_P85_iSH2 PF16454.5 PIK46063.1 - 0.64 9.6 16.8 0.74 9.4 12.0 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BRE1 PF08647.11 PIK46063.1 - 0.66 10.1 18.8 0.086 12.9 9.2 3.0 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase PRKG1_interact PF15898.5 PIK46063.1 - 0.67 10.9 19.8 0.71 10.8 7.6 2.8 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Tropomyosin PF00261.20 PIK46063.1 - 0.69 9.2 13.9 2.1 7.7 7.7 2.6 1 1 0 2 2 2 0 Tropomyosin GAS PF13851.6 PIK46063.1 - 0.71 9.2 16.8 0.73 9.2 12.5 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4094 PF13334.6 PIK46063.1 - 0.75 10.3 7.9 2.8 8.4 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) Peptidase_C65 PF10275.9 PIK46063.1 - 0.9 8.9 6.8 0.12 11.8 2.3 1.7 2 0 0 2 2 2 0 Peptidase C65 Otubain DivIC PF04977.15 PIK46063.1 - 0.92 9.3 11.1 1.4 8.7 1.5 3.4 2 1 2 4 4 3 0 Septum formation initiator LemA PF04011.12 PIK46063.1 - 1.1 9.2 8.1 0.75 9.6 5.5 2.0 2 0 0 2 2 2 0 LemA family bZIP_1 PF00170.21 PIK46063.1 - 1.1 9.4 16.3 8.2 6.6 1.7 4.1 2 1 2 4 4 4 0 bZIP transcription factor Spectrin PF00435.21 PIK46063.1 - 1.1 9.8 12.7 0.39 11.2 4.6 2.8 1 1 2 3 3 3 0 Spectrin repeat Phage_GPO PF05929.11 PIK46063.1 - 1.1 8.8 13.2 0.89 9.1 8.4 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Tho2 PF11262.8 PIK46063.1 - 1.1 8.3 10.1 0.21 10.7 6.8 1.5 2 0 0 2 2 1 0 Transcription factor/nuclear export subunit protein 2 AKNA PF12443.8 PIK46063.1 - 1.2 9.8 11.7 12 6.6 3.4 3.3 2 1 1 3 3 2 0 AT-hook-containing transcription factor Fzo_mitofusin PF04799.13 PIK46063.1 - 1.3 8.5 9.9 7.7 6.0 5.0 2.9 2 1 1 3 3 3 0 fzo-like conserved region ACCA PF03255.14 PIK46063.1 - 1.3 8.9 9.9 2 8.3 0.8 2.7 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Swi5 PF07061.11 PIK46063.1 - 1.3 9.1 10.9 1.5 8.9 2.5 3.0 1 1 2 3 3 3 0 Swi5 PIN_8 PF18476.1 PIK46063.1 - 1.3 8.8 9.3 0.49 10.2 5.1 1.9 1 1 1 2 2 2 0 PIN like domain TSC22 PF01166.18 PIK46063.1 - 1.4 9.3 9.0 9 6.7 2.2 3.1 2 1 0 2 2 2 0 TSC-22/dip/bun family WXG100 PF06013.12 PIK46063.1 - 1.4 9.2 10.3 4.3 7.6 3.8 3.4 2 2 1 3 3 3 0 Proteins of 100 residues with WXG DUF724 PF05266.14 PIK46063.1 - 1.6 8.5 17.7 1.1 9.0 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Het-C PF07217.11 PIK46063.1 - 1.6 7.2 11.7 0.96 7.9 10.0 1.5 1 1 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF4047 PF13256.6 PIK46063.1 - 1.6 8.9 6.8 2.1 8.5 5.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) YabA PF06156.13 PIK46063.1 - 1.6 9.4 16.6 0.27 11.9 7.6 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Cluap1 PF10234.9 PIK46063.1 - 1.8 7.9 13.3 3.6 6.9 13.3 1.6 1 1 0 1 1 1 0 Clusterin-associated protein-1 CENP-H PF05837.12 PIK46063.1 - 1.9 8.9 19.0 0.83 10.1 6.7 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) AATF-Che1 PF13339.6 PIK46063.1 - 1.9 9.1 16.6 25 5.5 13.9 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor SOAR PF16533.5 PIK46063.1 - 2.2 8.3 8.3 1.3 9.1 4.8 2.3 2 0 0 2 2 2 0 STIM1 Orai1-activating region STAT_alpha PF01017.20 PIK46063.1 - 2.5 8.0 17.2 2.3 8.1 12.4 2.5 1 1 1 2 2 2 0 STAT protein, all-alpha domain FapA PF03961.13 PIK46063.1 - 2.6 6.6 12.4 0.34 9.5 6.4 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 PIK46063.1 - 3 8.0 18.4 2.8 8.2 11.3 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 THOC7 PF05615.13 PIK46063.1 - 3.2 8.0 11.3 18 5.6 11.3 2.3 1 1 0 1 1 1 0 Tho complex subunit 7 DUF641 PF04859.12 PIK46063.1 - 3.3 8.1 10.9 0.49 10.7 3.5 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Vps51 PF08700.11 PIK46063.1 - 3.7 7.7 13.8 15 5.7 3.6 3.9 2 1 1 3 3 3 0 Vps51/Vps67 DUF3450 PF11932.8 PIK46063.1 - 3.7 6.8 13.5 2.9 7.1 10.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 PIK46063.1 - 3.7 5.3 16.8 4.1 5.2 9.7 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF3782 PF12644.7 PIK46063.1 - 4.2 7.6 7.4 3.1e+02 1.6 0.0 3.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3782) DUF2203 PF09969.9 PIK46063.1 - 4.2 8.1 8.7 4.2 8.1 3.4 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FliJ PF02050.16 PIK46063.1 - 5 7.4 13.3 0.8 9.9 4.8 2.7 1 1 1 2 2 2 0 Flagellar FliJ protein DUF16 PF01519.16 PIK46063.1 - 5.3 7.6 17.4 0.9 10.1 7.4 3.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 Spc24 PF08286.11 PIK46063.1 - 5.9 7.2 18.7 27 5.1 0.3 3.4 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Exonuc_VII_L PF02601.15 PIK46063.1 - 6.3 6.3 14.1 19 4.7 14.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit LUC7 PF03194.15 PIK46063.1 - 6.7 6.3 15.0 18 4.9 12.0 2.4 1 1 2 3 3 3 0 LUC7 N_terminus UPF0242 PF06785.11 PIK46063.1 - 7.5 6.6 18.1 1.1 9.3 11.8 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4200 PF13863.6 PIK46063.1 - 7.7 6.9 13.3 99 3.4 9.4 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF3967 PF13152.6 PIK46064.1 - 0.12 12.2 0.1 0.35 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) Ank_5 PF13857.6 PIK46065.1 - 2.1e-27 94.8 10.1 3.8e-11 43.0 0.2 6.9 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK46065.1 - 2.7e-27 95.2 10.7 3.2e-10 40.5 0.2 4.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK46065.1 - 2e-25 88.8 6.6 2e-05 25.0 0.0 5.6 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46065.1 - 7.8e-21 71.9 7.7 0.00015 21.9 0.1 7.8 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 PIK46065.1 - 5e-20 71.0 16.0 3.6e-05 24.0 0.2 8.0 7 1 1 8 8 8 5 Ankyrin repeat Patatin PF01734.22 PIK46065.1 - 0.00038 20.7 0.0 0.00077 19.7 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase EGF PF00008.27 PIK46066.1 - 3.7e-128 417.2 403.0 4e-07 30.2 5.6 28.5 28 0 0 28 28 28 28 EGF-like domain hEGF PF12661.7 PIK46066.1 - 2e-55 183.6 385.8 1.2e-06 28.9 3.0 29.7 28 0 0 28 28 28 28 Human growth factor-like EGF EGF_2 PF07974.13 PIK46066.1 - 1.5e-24 86.0 480.6 0.00079 19.7 7.1 28.4 28 0 0 28 28 28 25 EGF-like domain EGF_CA PF07645.15 PIK46066.1 - 2e-18 66.3 419.0 6.9e-06 26.2 10.9 28.3 12 12 16 28 28 28 14 Calcium-binding EGF domain Smg8_Smg9 PF10220.9 PIK46067.1 - 7.5e-34 117.2 0.2 8.8e-34 117.0 0.2 1.0 1 0 0 1 1 1 1 Smg8_Smg9 Smg8_Smg9 PF10220.9 PIK46068.1 - 9.2e-18 64.0 0.0 2e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Smg8_Smg9 RVT_1 PF00078.27 PIK46068.1 - 0.00027 20.5 0.0 0.00048 19.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lebercilin PF15619.6 PIK46068.1 - 0.11 12.1 0.1 0.11 12.1 0.1 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Smg8_Smg9 PF10220.9 PIK46069.1 - 1.7e-127 427.1 0.3 2.1e-127 426.8 0.3 1.0 1 0 0 1 1 1 1 Smg8_Smg9 R3H PF01424.22 PIK46070.1 - 0.012 15.5 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 R3H domain TMA7 PF09072.10 PIK46070.1 - 0.65 10.9 10.0 0.4 11.5 2.3 2.3 2 0 0 2 2 2 0 Translation machinery associated TMA7 WD40 PF00400.32 PIK46072.1 - 0.0026 18.6 0.3 4.4 8.3 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 PIK46072.1 - 0.026 14.6 0.0 0.096 12.7 0.0 1.9 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region zf-rbx1 PF12678.7 PIK46072.1 - 0.03 14.6 0.6 0.12 12.7 0.6 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 PIK46072.1 - 0.84 10.0 3.6 0.41 11.0 0.5 2.1 2 0 0 2 2 2 0 Ring finger domain Ig_mannosidase PF17753.1 PIK46073.1 - 2.4e-17 62.4 1.1 4.1e-17 61.7 1.1 1.4 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 PIK46073.1 - 0.0002 21.9 0.3 0.00069 20.2 0.0 2.0 3 0 0 3 3 3 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 PIK46074.1 - 1.2e-05 26.0 0.0 2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 PIK46074.1 - 0.00062 19.7 0.1 0.0015 18.5 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 PIK46074.1 - 0.017 14.2 0.1 0.087 11.9 0.1 2.0 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain SAND PF01342.21 PIK46075.1 - 2.7e-22 78.2 0.1 4.5e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 SAND domain SAM_1 PF00536.30 PIK46076.1 - 1.9e-11 44.2 0.0 3.2e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK46076.1 - 2.1e-11 43.7 0.0 3.6e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 PIK46076.1 - 0.002 18.3 0.0 0.0041 17.3 0.0 1.5 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 PIK46076.1 - 0.022 14.7 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain YesK PF14150.6 PIK46076.1 - 1.4 9.2 2.5 3 8.1 2.5 1.5 1 0 0 1 1 1 0 YesK-like protein Noc2 PF03715.13 PIK46077.1 - 1.2e-102 343.2 0.5 2e-102 342.5 0.5 1.3 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 PIK46077.1 - 0.063 11.5 26.9 0.33 9.1 0.0 2.0 2 0 0 2 2 2 0 Nop14-like family TPR_MLP1_2 PF07926.12 PIK46078.1 - 0.0019 18.2 7.3 0.0019 18.2 7.3 4.7 3 1 2 5 5 5 3 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 PIK46078.1 - 0.11 12.9 35.6 0.078 13.4 4.5 3.5 1 1 2 3 3 3 0 Fez1 DUF99 PF01949.16 PIK46078.1 - 0.85 9.0 3.6 2.7 7.4 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF99 GLE1 PF07817.13 PIK46078.1 - 1.1 8.5 7.5 0.32 10.2 3.7 1.9 1 1 1 2 2 2 0 GLE1-like protein APG6_N PF17675.1 PIK46078.1 - 1.5 9.3 50.6 12 6.4 9.6 4.3 3 1 1 4 4 4 0 Apg6 coiled-coil region DUF1664 PF07889.12 PIK46078.1 - 2.4 8.2 19.9 6.2 6.9 6.0 3.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF3416 PF11896.8 PIK46078.1 - 3.5 7.9 6.2 4.3 7.6 2.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3416) Fib_alpha PF08702.10 PIK46078.1 - 3.8 7.7 24.7 0.026 14.7 8.3 3.9 2 1 3 5 5 5 0 Fibrinogen alpha/beta chain family Flagellin_N PF00669.20 PIK46078.1 - 6 7.0 8.8 10 6.2 2.5 2.9 3 0 0 3 3 3 0 Bacterial flagellin N-terminal helical region RTP PF02334.16 PIK46078.1 - 7.5 7.2 8.3 13 6.5 0.9 3.0 2 1 1 3 3 3 0 Replication terminator protein HIP1_clath_bdg PF16515.5 PIK46079.1 - 0.0016 19.0 15.9 0.0016 19.0 15.9 6.5 2 1 4 6 6 6 2 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 PIK46079.1 - 0.021 15.4 5.7 0.021 15.4 5.7 5.2 2 1 3 5 5 5 0 Apg6 coiled-coil region ATG16 PF08614.11 PIK46079.1 - 0.058 13.6 76.8 0.041 14.1 10.1 4.8 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK46079.1 - 0.08 13.4 68.5 0.11 13.0 19.2 4.0 1 1 1 3 3 3 0 Fez1 SpoIIID PF12116.8 PIK46079.1 - 1.6 8.9 6.8 0.2 11.8 1.3 2.3 2 0 0 2 2 2 0 Stage III sporulation protein D DUF1664 PF07889.12 PIK46079.1 - 1.7 8.7 33.0 0.63 10.1 8.1 4.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Guanylate_cyc PF00211.20 PIK46081.1 - 8.2e-35 120.1 0.0 1.7e-34 119.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NIT PF08376.10 PIK46081.1 - 6.6e-17 62.7 0.0 1e-16 62.1 0.0 1.3 1 0 0 1 1 1 1 Nitrate and nitrite sensing HNOBA PF07701.14 PIK46081.1 - 6.3e-07 29.0 0.1 1.3e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Heme NO binding associated CECR6_TMEM121 PF14997.6 PIK46081.1 - 0.0023 17.8 0.1 0.025 14.4 0.4 2.1 2 0 0 2 2 2 1 CECR6/TMEM121 family DUF2681 PF10883.8 PIK46081.1 - 0.028 14.8 0.3 0.64 10.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF3180 PF11377.8 PIK46081.1 - 0.088 13.0 0.2 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) V-set PF07686.17 PIK46082.1 - 0.00026 21.1 0.6 0.0032 17.6 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain FtsX PF02687.21 PIK46082.1 - 0.041 14.4 0.0 0.066 13.7 0.0 1.2 1 0 0 1 1 1 0 FtsX-like permease family SpoIIIAH PF12685.7 PIK46082.1 - 0.043 13.7 2.6 0.065 13.1 2.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein PhoR PF11808.8 PIK46082.1 - 0.21 12.0 0.0 0.34 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR V-set PF07686.17 PIK46083.1 - 0.031 14.5 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 Immunoglobulin V-set domain DUF4983 PF16356.5 PIK46086.1 - 6e-10 39.8 0.0 7.9 7.4 0.0 7.4 1 1 11 12 12 12 3 Domain of unknown function (DUF4983) DUF1573 PF07610.11 PIK46086.1 - 9.2e-08 32.0 0.0 0.87 9.7 0.0 5.2 1 1 6 7 7 7 6 Protein of unknown function (DUF1573) Dr_adhesin PF12393.8 PIK46086.1 - 6.2e-07 29.4 18.5 13 6.3 0.1 9.8 11 0 0 11 11 11 4 Dr family adhesin SAP PF02037.27 PIK46087.1 - 2.2e-06 27.3 1.2 2.2e-06 27.3 1.2 1.9 2 0 0 2 2 2 1 SAP domain Ish1 PF10281.9 PIK46087.1 - 0.022 15.0 0.2 0.045 14.0 0.2 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Telomere_Sde2_2 PF13297.6 PIK46087.1 - 0.048 13.3 0.1 0.12 12.0 0.1 1.6 2 0 0 2 2 2 0 Telomere stability C-terminal UCH PF00443.29 PIK46088.1 - 1e-46 159.5 0.3 1.3e-46 159.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK46088.1 - 1.5e-21 77.3 3.4 8.7e-17 61.7 1.2 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CFIA_Pcf11 PF11526.8 PIK46088.1 - 0.26 11.8 3.0 14 6.3 0.4 2.8 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 TRM PF02005.16 PIK46090.1 - 7.4e-131 436.8 0.1 9.1e-131 436.5 0.1 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 PIK46090.1 - 8.5e-05 22.4 0.1 0.00016 21.5 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 PIK46090.1 - 0.018 15.7 0.0 0.052 14.3 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 PIK46090.1 - 0.038 13.8 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK46090.1 - 0.066 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 PIK46090.1 - 0.071 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 PIK46090.1 - 0.14 11.5 0.2 0.24 10.7 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ribosomal_L16 PF00252.18 PIK46091.1 - 5.3e-43 146.2 0.1 6.4e-43 145.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Malate_DH PF12434.8 PIK46091.1 - 0.035 14.1 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme Ribosomal_L16 PF00252.18 PIK46092.1 - 3.5e-14 52.9 0.1 3.8e-14 52.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Malate_DH PF12434.8 PIK46092.1 - 0.02 14.9 1.1 0.022 14.8 0.0 1.6 2 0 0 2 2 2 0 Malate dehydrogenase enzyme Pkinase_Tyr PF07714.17 PIK46093.1 - 2.2e-31 109.1 0.0 3.6e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46093.1 - 3e-20 72.7 0.0 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK46093.1 - 0.021 14.2 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ephrin_rec_like PF07699.13 PIK46094.1 - 4e-06 26.5 3.4 4e-06 26.5 3.4 4.8 3 2 2 5 5 5 3 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 PIK46095.1 - 1.5e-15 56.7 25.7 8e-11 41.5 4.9 4.7 3 1 1 4 4 4 3 Putative ephrin-receptor like Sushi PF00084.20 PIK46095.1 - 5.6e-07 30.1 2.3 5.6e-07 30.1 2.3 5.2 6 1 0 6 6 6 1 Sushi repeat (SCR repeat) HYR PF02494.16 PIK46095.1 - 2.8e-05 24.3 0.4 8.3e-05 22.8 0.4 1.8 1 0 0 1 1 1 1 HYR domain Pkinase_Tyr PF07714.17 PIK46096.1 - 6.8e-19 68.2 0.0 1.3e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46096.1 - 9.2e-10 38.3 0.0 1.7e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Marek_A PF02124.15 PIK46096.1 - 0.00052 19.9 0.3 0.00094 19.1 0.3 1.4 1 0 0 1 1 1 1 Marek's disease glycoprotein A Kinase-like PF14531.6 PIK46096.1 - 0.012 14.9 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like C2-set_2 PF08205.12 PIK46096.1 - 0.018 15.1 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain C2-set_2 PF08205.12 PIK46097.1 - 0.00092 19.2 0.0 0.0054 16.8 0.0 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK46098.1 - 4.8e-14 52.6 0.0 1.2e-13 51.3 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD PF17889.1 PIK46098.1 - 0.0036 17.6 0.2 0.016 15.5 0.2 2.2 1 0 0 1 1 1 1 NLRC4 helical domain AAA_22 PF13401.6 PIK46098.1 - 0.0065 16.7 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain TMEM154 PF15102.6 PIK46098.1 - 0.008 16.1 1.2 0.017 15.1 1.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family AAA_25 PF13481.6 PIK46098.1 - 0.034 13.7 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4446 PF14584.6 PIK46098.1 - 0.12 12.4 0.6 0.33 10.9 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) WD-3 PF09765.9 PIK46099.1 - 0.011 15.0 0.0 0.014 14.7 0.0 1.1 1 0 0 1 1 1 0 WD-repeat region NLE PF08154.12 PIK46100.1 - 1.4e-17 64.0 0.3 1.9e-17 63.5 0.3 1.2 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 PIK46100.1 - 0.022 15.6 0.7 0.057 14.3 0.7 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat DNA_mis_repair PF01119.19 PIK46101.1 - 2.1e-17 62.9 0.5 2.1e-16 59.6 0.0 2.5 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 PIK46101.1 - 2.1e-11 43.8 0.1 4.5e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK46101.1 - 1.6e-06 28.6 0.1 4.1e-06 27.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CLN5 PF15014.6 PIK46101.1 - 0.18 11.5 0.0 0.66 9.6 0.0 1.8 1 1 1 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 5 EamA PF00892.20 PIK46102.1 - 3.2e-26 92.2 30.6 1.2e-16 61.1 9.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family GST_C_3 PF14497.6 PIK46104.1 - 2.1e-20 72.7 0.0 4.2e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK46104.1 - 4.6e-10 39.6 0.0 8e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK46104.1 - 4.8e-05 23.3 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK46104.1 - 5.5e-05 23.4 0.0 9.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PduV-EutP PF10662.9 PIK46105.1 - 0.12 12.1 0.5 11 5.7 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MatE PF01554.18 PIK46106.1 - 0.093 12.4 13.5 0.033 13.9 1.7 2.8 2 1 1 3 3 3 0 MatE FtsX PF02687.21 PIK46108.1 - 0.0056 17.1 0.5 0.0056 17.1 0.5 2.4 3 1 0 3 3 3 1 FtsX-like permease family SRP1_TIP1 PF00660.17 PIK46108.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Seripauperin and TIP1 family TIR_2 PF13676.6 PIK46109.1 - 3.2e-40 137.4 0.9 2.9e-16 60.2 0.1 3.4 3 0 0 3 3 3 3 TIR domain TIR PF01582.20 PIK46109.1 - 9.3e-20 71.1 0.3 2e-06 27.7 0.0 3.9 4 1 1 5 5 5 3 TIR domain DUF1863 PF08937.11 PIK46109.1 - 0.041 14.2 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Mer2 PF09074.10 PIK46109.1 - 0.2 11.5 3.4 4.1 7.2 1.6 2.6 2 0 0 2 2 2 0 Mer2 DUF5582 PF17819.1 PIK46109.1 - 0.4 11.1 3.2 1.2 9.5 0.8 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5582) Glyco_transf_10 PF00852.19 PIK46110.1 - 2.5e-43 147.9 0.1 4.1e-43 147.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK46110.1 - 2.3e-06 28.0 0.1 6.9e-06 26.5 0.1 1.9 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Herpes_UL4 PF03277.13 PIK46110.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL4 family RVT_1 PF00078.27 PIK46111.1 - 5.2e-12 45.8 0.3 8.6e-12 45.0 0.1 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2498 PF10692.9 PIK46111.1 - 0.14 12.1 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) SelR PF01641.18 PIK46113.1 - 4e-17 62.4 0.1 4.2e-17 62.4 0.1 1.0 1 0 0 1 1 1 1 SelR domain TFIIS_C PF01096.18 PIK46113.1 - 0.024 14.5 0.1 6.6 6.7 0.0 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_ribbon_SprT PF17283.2 PIK46113.1 - 0.064 13.2 0.2 6 6.9 0.0 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-Mss51 PF13824.6 PIK46113.1 - 0.094 12.8 2.8 0.54 10.4 0.2 2.1 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Fam20C PF06702.12 PIK46114.1 - 2.4e-82 276.0 0.0 3e-82 275.7 0.0 1.0 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 PI3_PI4_kinase PF00454.27 PIK46114.1 - 0.043 13.6 0.8 0.1 12.4 0.5 1.8 2 1 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase Lectin_C PF00059.21 PIK46115.1 - 3.5e-18 66.3 0.4 5.7e-18 65.6 0.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK46115.1 - 8e-05 22.4 0.0 0.00015 21.4 0.0 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Intimin_C PF07979.11 PIK46115.1 - 0.071 13.5 0.5 0.15 12.5 0.2 1.6 2 0 0 2 2 2 0 Intimin C-type lectin domain Nucleopor_Nup85 PF07575.13 PIK46116.1 - 6.9e-142 473.9 17.8 1.1e-94 318.1 7.4 2.0 2 0 0 2 2 2 2 Nup85 Nucleoporin Chromo PF00385.24 PIK46117.1 - 4.1e-11 42.6 0.2 9.6e-11 41.4 0.2 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.3 PIK46117.1 - 4.8e-10 39.0 2.3 1.3e-09 37.6 2.3 1.7 1 0 0 1 1 1 1 CBX family C-terminal motif CDC45 PF02724.14 PIK46117.1 - 0.36 9.1 13.3 0.49 8.6 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CBX7_C PF17218.3 PIK46118.1 - 1.5e-08 34.2 0.6 3.9e-08 32.9 0.6 1.7 1 0 0 1 1 1 1 CBX family C-terminal motif zf-C2H2_4 PF13894.6 PIK46119.1 - 5.5e-11 42.3 103.7 0.017 15.9 0.3 15.3 15 0 0 15 15 15 8 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK46119.1 - 2.1e-05 24.7 106.4 0.0031 17.9 0.4 14.0 14 2 0 14 14 14 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK46119.1 - 4.4e-05 23.7 103.0 0.00039 20.7 0.1 15.9 17 1 0 17 17 17 7 Zinc-finger double domain zf-H2C2_5 PF13909.6 PIK46119.1 - 0.00023 20.8 0.4 0.00023 20.8 0.4 11.5 14 0 0 14 14 14 4 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 PIK46119.1 - 0.0058 16.4 0.0 0.0058 16.4 0.0 7.8 9 0 0 9 9 9 3 zinc-finger C2H2-type zf-Di19 PF05605.12 PIK46119.1 - 0.014 15.6 60.9 0.091 13.1 2.1 8.6 7 1 3 10 10 10 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 PIK46119.1 - 0.031 15.0 0.1 0.031 15.0 0.1 6.8 3 2 3 6 6 6 0 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 PIK46119.1 - 2 8.9 0.0 2 8.9 0.0 10.4 7 4 4 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 PIK46120.1 - 0.028 14.3 0.7 0.073 13.0 0.7 1.7 1 0 0 1 1 1 0 zinc-finger of a C2HC-type ING PF12998.7 PIK46121.1 - 2.1e-24 86.1 3.6 2.1e-24 86.1 3.6 2.1 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 PIK46121.1 - 2.3e-05 24.2 7.0 4.7e-05 23.2 7.0 1.6 1 0 0 1 1 1 1 PHD-finger Endostatin PF06482.11 PIK46121.1 - 0.3 10.5 4.8 0.34 10.3 4.8 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin zf-HC5HC2H PF13771.6 PIK46121.1 - 0.33 11.2 3.8 0.99 9.7 3.4 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain RRN3 PF05327.11 PIK46121.1 - 0.58 8.6 11.4 0.4 9.2 9.7 1.5 1 1 1 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 MCM_bind PF09739.9 PIK46121.1 - 1 7.7 11.3 1.7 7.0 11.3 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 PIK46121.1 - 1.9 8.2 13.9 2.4 7.9 13.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 PIK46121.1 - 8 5.1 11.0 12 4.5 11.0 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 PIK46121.1 - 8.7 4.5 13.0 12 4.1 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 PIK46121.1 - 9.3 5.4 7.2 11 5.1 7.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Arfaptin PF06456.13 PIK46122.1 - 1.1e-54 185.4 3.1 1.3e-54 185.2 3.1 1.0 1 0 0 1 1 1 1 Arfaptin-like domain BAR_3 PF16746.5 PIK46122.1 - 0.18 11.5 6.2 0.27 10.9 6.2 1.3 1 1 0 1 1 1 0 BAR domain of APPL family TNFR_c6 PF00020.18 PIK46123.1 - 4.9e-18 65.2 38.0 1.1e-07 32.1 5.7 3.5 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region TMEM154 PF15102.6 PIK46123.1 - 0.034 14.1 0.4 0.06 13.3 0.4 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF1771 PF08590.10 PIK46124.1 - 5.4e-21 74.7 11.6 5.4e-21 74.7 11.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 PIK46124.1 - 2.8e-10 40.4 0.0 6.5e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Smr domain AntA PF08346.12 PIK46124.1 - 0.46 11.1 2.3 0.39 11.3 0.3 1.8 2 0 0 2 2 2 0 AntA/AntB antirepressor DpaA_N PF16924.5 PIK46125.1 - 0.11 12.6 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain AAA_33 PF13671.6 PIK46126.1 - 1e-17 64.6 0.0 2.8e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK46126.1 - 1.3e-05 25.7 0.0 2.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 PIK46126.1 - 1.4e-05 24.7 0.0 3.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 PIK46126.1 - 2.1e-05 25.0 0.1 4.8e-05 23.8 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK46126.1 - 0.0085 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 PIK46126.1 - 0.0089 15.6 0.0 0.037 13.6 0.0 1.9 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 PIK46126.1 - 0.0098 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Zeta_toxin PF06414.12 PIK46126.1 - 0.012 14.9 0.0 0.038 13.3 0.0 1.8 1 1 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 PIK46126.1 - 0.033 14.5 0.0 0.078 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 PIK46126.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SCIMP PF15050.6 PIK46127.1 - 6.6 7.2 5.6 0.62 10.5 0.7 1.7 2 0 0 2 2 2 0 SCIMP protein TMEM144 PF07857.12 PIK46128.1 - 2.3e-90 303.0 6.9 3e-90 302.6 6.9 1.1 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 PIK46128.1 - 6.4e-10 38.8 10.5 2.1e-08 33.9 6.1 2.3 2 0 0 2 2 2 2 Sugar transport protein UNC-50 PF05216.13 PIK46129.1 - 3.4e-72 242.6 19.2 3.9e-72 242.4 19.2 1.0 1 0 0 1 1 1 1 UNC-50 family Peptidase_M10 PF00413.24 PIK46130.1 - 1e-43 149.0 0.0 1.6e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK46130.1 - 2.8e-06 27.2 0.1 7.4e-06 25.8 0.1 1.8 1 0 0 1 1 1 1 Hemopexin PG_binding_1 PF01471.18 PIK46130.1 - 3.5e-05 23.9 0.0 9.1e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 PIK46130.1 - 0.0024 17.5 0.1 0.0041 16.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK46130.1 - 0.013 16.0 0.4 0.025 15.1 0.4 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 PIK46130.1 - 0.025 13.2 0.0 0.038 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 PIK46130.1 - 0.035 14.3 0.1 0.062 13.4 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.5 PIK46130.1 - 0.037 13.3 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Abhydrolase_1 PF00561.20 PIK46131.1 - 3e-18 66.4 0.3 3.2e-16 59.7 0.3 3.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK46131.1 - 4.2e-13 50.4 0.0 5.8e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family HAD_2 PF13419.6 PIK46131.1 - 6.5e-13 49.2 0.0 1.3e-12 48.2 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK46131.1 - 1.4e-11 45.1 0.0 3.7e-11 43.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK46131.1 - 4.8e-07 29.8 0.0 9.5e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_4 PF12146.8 PIK46131.1 - 0.0065 15.8 0.0 0.34 10.2 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF3231 PF11553.8 PIK46131.1 - 0.047 13.3 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3231) T4BSS_DotI_IcmL PF11393.8 PIK46131.1 - 0.14 11.6 0.0 16 4.9 0.0 2.3 2 0 0 2 2 2 0 Type-IV b secretion system, inner-membrane complex component RVT_1 PF00078.27 PIK46134.1 - 1.6e-37 129.2 1.0 2.3e-37 128.6 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HYR PF02494.16 PIK46136.1 - 7.4e-37 125.5 7.8 5e-18 65.2 0.2 2.2 2 0 0 2 2 2 2 HYR domain GIY-YIG PF01541.24 PIK46137.1 - 6.6e-05 23.1 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK46137.1 - 0.008 15.7 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Calx-beta PF03160.14 PIK46138.1 - 1.1e-08 35.1 4.5 1.3e-08 34.9 2.3 1.8 2 0 0 2 2 2 1 Calx-beta domain Cadherin-like PF12733.7 PIK46138.1 - 0.0038 17.7 5.7 0.0063 17.0 2.1 2.0 1 1 1 2 2 2 2 Cadherin-like beta sandwich domain FAD_binding_8 PF08022.12 PIK46140.1 - 9e-24 83.7 0.6 3.6e-20 72.1 0.0 2.9 3 0 0 3 3 3 2 FAD-binding domain NAD_binding_6 PF08030.12 PIK46140.1 - 3.1e-19 69.6 0.0 8.5e-19 68.2 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 PIK46140.1 - 1.1e-14 54.7 14.0 1.1e-14 54.7 14.0 1.7 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 PIK46140.1 - 0.0036 17.9 0.0 0.013 16.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 PIK46140.1 - 0.011 16.1 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain DUF373 PF04123.13 PIK46140.1 - 9 5.6 6.8 34 3.7 6.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Hus1 PF04005.12 PIK46141.1 - 8e-69 232.0 0.3 9.3e-69 231.8 0.3 1.0 1 0 0 1 1 1 1 Hus1-like protein UAA PF08449.11 PIK46142.1 - 2e-60 204.5 12.6 2.5e-60 204.3 12.6 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 PIK46142.1 - 1.6e-13 50.7 11.0 2.7e-13 49.9 11.0 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 PIK46142.1 - 1.5e-12 47.9 23.8 1e-08 35.4 9.9 2.9 2 1 1 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 PIK46142.1 - 2.5e-06 26.9 6.1 0.00013 21.3 1.2 2.2 1 1 1 2 2 2 2 Nucleotide-sugar transporter CRT-like PF08627.10 PIK46142.1 - 0.0018 17.3 1.0 0.0018 17.3 1.0 2.3 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like DUF1335 PF07056.11 PIK46142.1 - 0.12 12.4 2.4 0.13 12.4 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1335) SLC35F PF06027.12 PIK46142.1 - 0.13 11.8 7.8 0.2 11.1 7.8 1.3 1 0 0 1 1 1 0 Solute carrier family 35 ISK_Channel PF02060.15 PIK46142.1 - 0.16 11.7 0.6 1.3 8.8 0.0 2.5 3 0 0 3 3 3 0 Slow voltage-gated potassium channel TMEM234 PF10639.9 PIK46142.1 - 0.47 10.5 6.2 1.5 8.8 1.6 2.6 2 1 0 2 2 2 0 Putative transmembrane family 234 LRR_6 PF13516.6 PIK46143.1 - 2.7e-07 30.1 25.3 1.8 8.8 0.1 11.3 13 0 0 13 13 13 3 Leucine Rich repeat LRR_4 PF12799.7 PIK46143.1 - 0.00059 20.2 13.9 1.5 9.4 0.0 7.8 6 2 3 9 9 9 1 Leucine Rich repeats (2 copies) Preseq_ALAS PF09029.10 PIK46143.1 - 0.081 13.4 0.7 0.54 10.8 0.0 2.8 3 0 0 3 3 3 0 5-aminolevulinate synthase presequence LRR_2 PF07723.13 PIK46143.1 - 0.86 10.4 4.4 15 6.4 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_1 PF00560.33 PIK46143.1 - 5.8 7.9 20.5 24 6.0 0.8 8.0 9 2 0 9 9 9 0 Leucine Rich Repeat UPF0184 PF03670.13 PIK46143.1 - 7.5 7.0 9.5 12 6.4 0.1 4.4 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0184) Mito_carr PF00153.27 PIK46144.1 - 6.1e-52 173.5 5.9 1.9e-18 66.1 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK46144.1 - 0.1 11.7 3.0 20 4.2 0.0 3.9 2 2 1 4 4 4 0 Gammaproteobacterial serine protease Ank_2 PF12796.7 PIK46145.1 - 2.7e-19 69.5 2.2 5.6e-12 46.1 0.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK46145.1 - 2.9e-19 69.2 0.0 7.1e-07 29.7 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK46145.1 - 8.2e-17 61.1 0.1 1.8e-09 37.7 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK46145.1 - 3.1e-15 55.8 0.2 2.7e-05 24.4 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK46145.1 - 3.2e-12 45.5 0.0 0.015 15.8 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeat SIS PF01380.22 PIK46145.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 SIS domain zf-RING_2 PF13639.6 PIK46146.1 - 2.3e-09 37.5 4.8 3.3e-09 36.9 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 PIK46146.1 - 5.2e-07 29.5 5.6 7.6e-07 29.0 5.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK46146.1 - 8.2e-07 28.9 5.6 1.6e-06 28.0 5.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK46146.1 - 3.9e-06 26.6 3.4 5.5e-06 26.1 3.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK46146.1 - 5.3e-06 26.6 4.6 1.3e-05 25.4 4.6 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK46146.1 - 8.2e-06 25.8 1.4 1.5e-05 25.0 1.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 PIK46146.1 - 9.5e-06 25.3 3.6 1.9e-05 24.3 3.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 PIK46146.1 - 1.9e-05 24.4 4.9 3.1e-05 23.8 4.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK46146.1 - 7.6e-05 22.5 6.5 0.00012 21.8 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK46146.1 - 7.7e-05 22.5 4.3 0.00012 21.8 4.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-HC5HC2H_2 PF13832.6 PIK46146.1 - 0.0032 17.6 1.9 0.005 17.0 0.1 1.8 1 1 1 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 PIK46146.1 - 0.0077 16.5 2.0 0.031 14.5 2.0 1.9 1 1 0 1 1 1 1 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 PIK46146.1 - 0.011 15.3 2.0 0.02 14.5 2.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Pellino PF04710.14 PIK46146.1 - 0.041 12.6 0.2 0.07 11.8 0.2 1.3 1 0 0 1 1 1 0 Pellino zf-Nse PF11789.8 PIK46146.1 - 0.056 13.3 1.5 0.1 12.4 1.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.11 PIK46146.1 - 0.089 13.1 4.2 0.17 12.2 4.2 1.5 1 1 0 1 1 1 0 RING-like domain zf-UDP PF14569.6 PIK46146.1 - 0.13 12.4 0.9 0.24 11.5 0.9 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_9 PF13901.6 PIK46146.1 - 0.16 11.9 3.5 0.27 11.2 2.3 1.8 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 PIK46146.1 - 0.16 11.9 3.8 0.33 10.9 3.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_6 PF14835.6 PIK46146.1 - 0.17 11.8 1.1 0.29 11.0 1.1 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zf_RING PF16744.5 PIK46146.1 - 0.17 12.0 2.8 1.9 8.6 3.6 2.1 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C3HC4_4 PF15227.6 PIK46146.1 - 0.37 11.0 4.1 1.6 8.9 4.5 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 PIK46146.1 - 0.41 10.5 2.7 0.75 9.6 2.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 PIK46146.1 - 1.7 8.7 7.1 5.1 7.2 7.1 1.9 1 1 0 1 1 1 0 Zinc-finger zf-RING_2 PF13639.6 PIK46147.1 - 5.2e-07 29.9 3.0 5.1e-05 23.5 0.6 2.4 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 PIK46147.1 - 7.3e-07 29.0 2.2 4.3e-05 23.3 0.3 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK46147.1 - 2.8e-06 27.2 4.3 4.1e-05 23.4 4.8 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK46147.1 - 4e-06 26.6 3.1 0.00013 21.7 0.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK46147.1 - 1.9e-05 24.6 2.1 0.00038 20.4 0.2 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 PIK46147.1 - 2.4e-05 24.5 2.5 0.0001 22.5 2.6 2.0 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 PIK46147.1 - 5.7e-05 22.8 2.0 0.0037 17.0 0.1 2.9 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_4 PF14570.6 PIK46147.1 - 0.00096 18.9 0.7 0.018 14.8 0.1 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 PIK46147.1 - 0.0011 18.8 4.8 0.033 14.0 1.5 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) IQ PF00612.27 PIK46147.1 - 0.0022 17.7 3.4 0.0022 17.7 3.4 1.9 2 0 0 2 2 1 1 IQ calmodulin-binding motif zf-C3HC4 PF00097.25 PIK46147.1 - 0.0024 17.7 5.8 0.04 13.8 6.8 2.4 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 PIK46147.1 - 0.0031 17.5 1.4 0.0083 16.2 1.4 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 PIK46147.1 - 0.068 12.8 5.3 0.15 11.7 0.1 2.5 2 0 0 2 2 2 0 P-11 zinc finger Zn-ribbon_8 PF09723.10 PIK46147.1 - 0.08 13.1 5.3 0.67 10.1 0.7 2.9 2 1 0 2 2 2 0 Zinc ribbon domain TMEM214 PF10151.9 PIK46147.1 - 0.097 11.1 0.1 0.11 10.9 0.1 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Zn_ribbon_17 PF17120.5 PIK46147.1 - 0.12 12.0 2.7 0.33 10.6 1.1 2.3 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type zinc-ribbons_6 PF07191.12 PIK46147.1 - 0.15 12.1 3.5 9.9 6.2 0.8 2.5 2 1 0 2 2 2 0 zinc-ribbons zf-C3HC4_4 PF15227.6 PIK46147.1 - 1.7 8.9 5.8 3.9 7.7 2.4 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn-C2H2_12 PF18112.1 PIK46147.1 - 2.2 8.8 6.9 1.1 9.7 0.6 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain EGF_2 PF07974.13 PIK46148.1 - 4.5e-09 36.5 78.7 0.00029 21.2 10.4 5.7 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 PIK46148.1 - 6.8e-08 32.9 66.7 0.00041 20.9 8.4 7.0 7 0 0 7 7 7 4 Human growth factor-like EGF EGF PF00008.27 PIK46148.1 - 3e-05 24.2 73.7 0.00051 20.3 9.1 6.1 6 1 0 6 6 6 4 EGF-like domain Pro_dh PF01619.18 PIK46149.1 - 9.6e-80 268.3 0.0 1.9e-79 267.3 0.0 1.5 1 1 0 1 1 1 1 Proline dehydrogenase EF-hand_7 PF13499.6 PIK46149.1 - 0.091 13.2 0.8 3.9 8.0 0.2 2.9 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK46149.1 - 0.091 12.7 0.0 0.86 9.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain MR_MLE_C PF13378.6 PIK46149.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Enolase C-terminal domain-like T-box PF00907.22 PIK46150.1 - 1.9e-71 240.1 1.6 2.7e-71 239.6 1.6 1.2 1 0 0 1 1 1 1 T-box zf-CCHC PF00098.23 PIK46151.1 - 2.7e-06 27.2 1.4 6e-06 26.1 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK46151.1 - 0.00097 19.4 0.0 0.0038 17.4 0.0 2.0 2 0 0 2 2 2 1 Retrotransposon gag protein Cluap1 PF10234.9 PIK46151.1 - 0.017 14.5 0.4 0.029 13.8 0.4 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 Herpes_UL6 PF01763.16 PIK46151.1 - 0.073 11.6 0.2 0.1 11.1 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like FliD_N PF02465.18 PIK46151.1 - 0.1 13.3 0.0 0.21 12.3 0.0 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus bZIP_1 PF00170.21 PIK46151.1 - 1.9 8.6 4.2 11 6.2 0.4 2.5 2 0 0 2 2 2 0 bZIP transcription factor GCV_H PF01597.19 PIK46152.1 - 0.011 15.6 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein Spuma_A9PTase PF03539.14 PIK46152.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) RT_RNaseH_2 PF17919.1 PIK46153.1 - 3.9e-36 123.1 0.0 6.9e-36 122.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46153.1 - 8.7e-25 87.0 0.0 1.8e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK46153.1 - 4.8e-24 84.8 0.0 1e-23 83.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46153.1 - 2.5e-17 62.7 0.9 7.4e-17 61.2 0.9 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46153.1 - 0.00055 19.7 0.0 0.0016 18.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK46153.1 - 0.0017 18.5 0.0 0.0038 17.4 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger FtsK_SpoIIIE_N PF12538.8 PIK46154.1 - 0.03 14.5 2.7 0.063 13.5 2.7 1.5 1 0 0 1 1 1 0 DNA transporter DEAD_2 PF06733.15 PIK46155.1 - 1.5e-53 181.0 0.5 7.1e-53 178.8 0.2 2.2 1 1 1 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.6 PIK46155.1 - 3.5e-42 144.5 0.0 1.7e-41 142.3 0.0 2.1 1 1 1 2 2 2 1 Helicase C-terminal domain SNF2_N PF00176.23 PIK46155.1 - 0.0031 16.3 0.0 0.0052 15.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HBB PF06777.11 PIK46155.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Helical and beta-bridge domain Transmemb_17 PF09799.9 PIK46156.1 - 1.4e-26 93.1 11.8 1.8e-26 92.8 11.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein TMEM251 PF15190.6 PIK46156.1 - 0.051 13.5 0.2 0.051 13.5 0.2 2.2 1 1 0 2 2 2 0 Transmembrane protein 251 DUF5090 PF17009.5 PIK46156.1 - 5.4 6.9 8.3 10 6.0 3.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF5090) 7tm_1 PF00001.21 PIK46157.1 - 6.7e-17 61.7 6.3 9.1e-17 61.2 6.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46157.1 - 2.3e-11 43.8 8.8 2.8e-11 43.5 8.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK46157.1 - 1.6e-09 37.5 4.0 2.2e-09 37.1 4.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK46157.1 - 6.5e-08 32.3 5.5 6.5e-08 32.3 5.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.9 PIK46157.1 - 0.01 15.4 10.9 0.017 14.7 10.9 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc Sugar_tr PF00083.24 PIK46158.1 - 1.3e-24 86.9 1.1 1.3e-24 86.9 1.1 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK46158.1 - 4.1e-20 72.0 6.2 4.1e-20 72.0 6.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK46158.1 - 0.0004 19.1 2.0 0.00097 17.8 2.0 1.6 1 0 0 1 1 1 1 MFS/sugar transport protein ATPase_gene1 PF09527.10 PIK46158.1 - 0.0015 18.7 1.0 0.0015 18.7 1.0 2.6 2 2 1 3 3 3 1 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter TRI12 PF06609.13 PIK46158.1 - 0.013 14.0 0.1 0.017 13.5 0.1 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 PIK46159.1 - 3.3e-05 23.0 0.1 3.7e-05 22.8 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK46159.1 - 0.0035 16.3 4.0 0.0043 16.0 4.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Gp45_2 PF17470.2 PIK46159.1 - 0.061 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Phage gene product 45.2 DNA_pol_B_2 PF03175.13 PIK46161.1 - 9e-13 47.9 0.2 3e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral 7tm_1 PF00001.21 PIK46163.1 - 4.8e-37 127.7 6.1 4.8e-37 127.7 6.1 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK46163.1 - 4.9e-11 42.5 13.0 2.6e-10 40.1 13.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK46163.1 - 1.6e-10 41.1 8.4 1.6e-10 41.1 8.4 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Srg PF02118.21 PIK46163.1 - 0.0024 17.6 6.2 0.0024 17.6 6.2 2.7 3 0 0 3 3 3 1 Srg family chemoreceptor DUF4577 PF15145.6 PIK46163.1 - 0.11 12.5 0.4 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) 7tm_1 PF00001.21 PIK46164.1 - 1.3e-27 96.8 8.8 1.6e-27 96.5 8.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46164.1 - 4.8e-10 39.5 10.4 5.8e-10 39.2 10.4 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK46164.1 - 6.6e-07 29.0 8.8 8e-07 28.7 8.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK46164.1 - 7.4e-05 22.2 11.3 9.8e-05 21.9 11.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2207 PF09972.9 PIK46164.1 - 1.3 7.7 3.5 0.36 9.6 0.6 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) 7tm_1 PF00001.21 PIK46165.1 - 7.8e-29 100.8 10.2 9.6e-29 100.5 10.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46165.1 - 1e-11 45.0 11.9 1.2e-11 44.7 11.9 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK46165.1 - 4.3e-07 29.6 11.0 5.2e-07 29.3 11.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK46165.1 - 0.00019 20.9 14.0 0.00025 20.5 14.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2207 PF09972.9 PIK46165.1 - 4 6.1 4.7 0.63 8.7 0.8 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) ubiquitin PF00240.23 PIK46166.1 - 3.1e-170 552.3 35.8 2.5e-33 113.6 0.4 9.0 8 1 1 9 9 9 8 Ubiquitin family Rad60-SLD PF11976.8 PIK46166.1 - 5.2e-79 260.1 28.3 7.2e-16 57.8 0.4 8.1 7 1 1 8 8 8 8 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK46166.1 - 1.7e-33 114.9 12.0 5.4e-06 26.8 0.1 7.3 5 3 1 6 6 6 6 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK46166.1 - 1.1e-19 70.1 2.3 0.025 14.5 0.0 6.6 5 2 2 7 7 7 5 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK46166.1 - 3.4e-15 56.1 1.5 0.06 13.5 0.0 6.0 5 2 0 5 5 5 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 PIK46166.1 - 4.6e-14 52.6 1.9 0.072 13.4 0.1 4.6 4 0 0 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 PIK46166.1 - 1.3e-11 45.0 1.8 0.45 11.1 0.0 4.8 2 2 2 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 PIK46166.1 - 1.3e-08 34.9 6.1 0.45 10.3 0.8 5.9 1 1 4 5 5 5 3 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 PIK46166.1 - 3.2e-08 33.2 0.8 4 6.7 0.0 5.0 5 0 0 5 5 5 2 RNA methyltransferase RBD PF02196.15 PIK46166.1 - 6.7e-07 29.3 0.1 24 5.1 0.0 6.4 6 1 0 7 7 6 0 Raf-like Ras-binding domain Ubiquitin_4 PF18036.1 PIK46166.1 - 4.1e-06 26.8 24.7 0.6 10.2 0.0 8.9 10 1 0 10 10 8 1 Ubiquitin-like domain UDP-g_GGTase PF06427.11 PIK46166.1 - 4.5e-06 26.7 6.6 12 6.1 0.0 5.5 6 0 0 6 6 6 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF2870 PF11069.8 PIK46166.1 - 6.3e-05 23.3 0.0 55 4.2 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) GDYXXLXY PF14345.6 PIK46166.1 - 0.0008 19.2 1.2 2e+02 1.7 0.0 5.9 6 0 0 6 6 6 0 GDYXXLXY protein TraK PF06586.11 PIK46166.1 - 0.0012 18.6 1.1 1.6e+02 1.8 0.0 5.6 6 0 0 6 6 6 0 TraK protein DUF3861 PF12977.7 PIK46166.1 - 0.0023 18.1 2.7 90 3.3 0.0 5.7 5 1 1 6 6 6 0 Domain of Unknown Function with PDB structure (DUF3861) Big_3_3 PF13750.6 PIK46166.1 - 0.0032 17.1 1.7 20 4.8 0.0 5.5 4 2 3 7 7 7 0 Bacterial Ig-like domain (group 3) DUF969 PF06149.12 PIK46166.1 - 0.0034 16.8 0.0 48 3.3 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF969) CorA PF01544.18 PIK46166.1 - 0.0047 16.3 2.3 13 5.0 0.0 4.9 5 1 0 5 5 5 0 CorA-like Mg2+ transporter protein ORF11CD3 PF10549.9 PIK46166.1 - 0.0052 16.9 0.0 1.7e+02 2.4 0.0 4.8 4 0 0 4 4 4 0 ORF11CD3 domain EstA_Ig_like PF18435.1 PIK46166.1 - 0.0095 16.1 4.8 23 5.2 0.1 5.4 6 0 0 6 6 6 0 Esterase Ig-like N-terminal domain YcgR_2 PF12945.7 PIK46166.1 - 0.017 15.3 10.1 1e+02 3.2 0.0 6.1 6 0 0 6 6 6 0 Flagellar protein YcgR Baculo_p48 PF04878.13 PIK46166.1 - 0.2 10.5 0.0 1.1e+02 1.6 0.0 3.8 4 0 0 4 4 4 0 Baculovirus P48 protein DUF5450 PF17529.2 PIK46166.1 - 0.34 11.0 1.3 1.1e+02 2.9 0.0 4.3 3 1 1 5 5 5 0 Family of unknown function (DUF5450) HAMP_N3 PF18575.1 PIK46166.1 - 1.4 8.5 6.8 3.5e+02 0.9 0.0 5.4 6 0 0 6 6 6 0 HAMP N-terminal domain 3 ProRS-C_2 PF09181.10 PIK46166.1 - 1.4 9.1 8.9 2.8e+02 1.7 0.0 5.6 6 0 0 6 6 6 0 Prolyl-tRNA synthetase, C-terminal LCM PF04072.14 PIK46166.1 - 2.7 7.9 3.9 3.4 7.6 0.1 2.9 4 1 0 4 4 4 0 Leucine carboxyl methyltransferase DUF1059 PF06348.11 PIK46166.1 - 3.5 7.9 13.5 17 5.7 0.1 5.6 6 0 0 6 6 6 0 Protein of unknown function (DUF1059) ubiquitin PF00240.23 PIK46167.1 - 3.6e-49 164.4 3.5 3.2e-34 116.5 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK46167.1 - 1.2e-24 85.9 2.1 9.3e-17 60.6 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK46167.1 - 9.6e-12 45.2 0.5 3.4e-05 24.2 0.1 2.7 2 1 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK46167.1 - 0.00032 20.6 0.1 0.0062 16.4 0.0 2.3 2 1 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 PIK46167.1 - 0.0014 18.6 3.2 10 6.3 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK46167.1 - 0.0016 18.5 0.1 0.027 14.6 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Sde2_N_Ubi PF13019.6 PIK46167.1 - 0.0026 17.6 0.5 0.43 10.4 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_5 PF18037.1 PIK46167.1 - 0.0052 17.1 0.1 0.01 16.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain RBD PF02196.15 PIK46167.1 - 0.01 15.9 0.0 4.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain DUF2407 PF10302.9 PIK46167.1 - 0.041 14.4 0.1 0.082 13.5 0.1 1.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain YcgR_2 PF12945.7 PIK46167.1 - 0.11 12.6 0.8 20 5.4 0.1 2.5 2 1 0 2 2 2 0 Flagellar protein YcgR DEAD PF00270.29 PIK46168.1 - 4.1e-39 134.1 0.0 1.1e-38 132.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK46168.1 - 8.8e-24 84.0 0.1 5.3e-23 81.5 0.0 2.3 2 1 1 3 3 3 1 Helicase conserved C-terminal domain Phage_integrase PF00589.22 PIK46168.1 - 0.011 15.5 0.1 0.027 14.3 0.0 1.6 2 0 0 2 2 2 0 Phage integrase family ResIII PF04851.15 PIK46168.1 - 0.018 15.0 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TM2 PF05154.16 PIK46169.1 - 3.7e-15 56.0 9.3 7.6e-15 55.0 9.3 1.5 1 0 0 1 1 1 1 TM2 domain ErmC PF06308.11 PIK46169.1 - 3.4 8.1 5.0 6.9 7.1 5.0 1.5 1 0 0 1 1 1 0 23S rRNA methylastransferase leader peptide (ErmCL) mRNA_cap_enzyme PF01331.19 PIK46170.1 - 0.18 11.6 0.0 0.27 11.0 0.0 1.3 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain Ig_3 PF13927.6 PIK46172.1 - 1.3e-17 64.1 6.6 6.7e-05 23.4 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK46172.1 - 2e-16 59.8 0.2 5.8e-07 29.5 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.25 PIK46172.1 - 2.3e-13 50.1 3.4 3.6e-06 27.1 0.0 4.3 4 1 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK46172.1 - 4e-10 39.9 0.1 0.009 16.3 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK46172.1 - 4.3e-10 39.7 0.1 3e-07 30.6 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK46172.1 - 1.6e-05 24.9 0.4 0.005 16.9 0.0 3.2 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Chordopox_A13L PF05961.11 PIK46172.1 - 0.15 12.3 2.9 0.41 10.9 2.9 1.8 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Orf78 PF06024.12 PIK46172.1 - 0.17 12.2 0.1 0.54 10.6 0.1 1.8 1 0 0 1 1 1 0 Orf78 (ac78) p47_phox_C PF08944.11 PIK46172.1 - 1.5 8.3 7.2 4.9 6.6 7.2 1.9 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain CBP_BcsF PF11120.8 PIK46172.1 - 6.2 7.0 6.7 11 6.2 6.7 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF ECSCR PF15820.5 PIK46173.1 - 0.055 13.3 0.5 0.12 12.2 0.1 1.7 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Myosin_head PF00063.21 PIK46174.1 - 1.1e-247 823.7 5.2 1.3e-247 823.4 5.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 PIK46174.1 - 1.9e-25 89.7 0.4 4.3e-25 88.5 0.4 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 PIK46174.1 - 1.7e-06 27.5 0.4 3.8e-06 26.4 0.4 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK46174.1 - 0.00019 21.2 0.1 0.00045 20.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK46174.1 - 0.0013 18.4 0.0 0.0029 17.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.6 PIK46174.1 - 0.026 14.9 0.0 0.16 12.3 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain AAA_23 PF13476.6 PIK46174.1 - 0.036 14.6 2.2 0.18 12.3 2.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK46174.1 - 0.076 13.3 0.1 0.23 11.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 PIK46174.1 - 0.1 12.3 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.12 PIK46174.1 - 0.13 11.8 0.2 12 5.4 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain CbiA PF01656.23 PIK46174.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain EGF PF00008.27 PIK46175.1 - 1.6e-26 92.3 56.0 4.2e-07 30.2 5.9 4.8 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK46175.1 - 5.1e-23 80.8 45.0 1.7e-05 25.2 6.8 5.2 4 0 0 4 4 4 4 Human growth factor-like EGF SRCR PF00530.18 PIK46175.1 - 9.1e-18 64.6 3.2 9.1e-18 64.6 3.2 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain EGF_2 PF07974.13 PIK46175.1 - 4.4e-07 30.2 71.3 0.0056 17.0 13.4 5.3 4 1 0 4 4 4 3 EGF-like domain FXa_inhibition PF14670.6 PIK46175.1 - 0.0027 18.0 47.9 0.088 13.1 5.3 4.8 1 1 3 4 4 4 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK46175.1 - 0.086 13.1 49.8 0.92 9.8 7.8 5.4 3 1 1 4 4 4 0 EGF domain EGF_CA PF07645.15 PIK46175.1 - 0.5 10.6 57.5 1.5 9.1 4.2 5.2 1 1 4 5 5 5 0 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 PIK46175.1 - 3.2 7.9 51.8 0.7 10.0 5.8 4.6 4 0 0 4 4 4 0 MSP1 EGF domain 1 SRCR PF00530.18 PIK46176.1 - 8.9e-24 83.9 4.4 1.1e-23 83.6 4.4 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK46176.1 - 0.0043 17.6 0.5 0.0043 17.6 0.5 1.8 1 1 1 2 2 2 1 Scavenger receptor cysteine-rich domain RT_RNaseH PF17917.1 PIK46177.1 - 2.1e-23 82.6 0.0 3.1e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46177.1 - 9.8e-15 54.4 0.0 1.7e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK46177.1 - 0.00026 21.0 0.0 0.00051 20.1 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain ALMT PF11744.8 PIK46178.1 - 1.1 8.0 5.5 1.3 7.7 5.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ig_3 PF13927.6 PIK46179.1 - 4.5e-05 24.0 0.1 0.00056 20.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK46179.1 - 0.00021 21.5 0.5 0.0012 19.1 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK46179.1 - 0.0021 18.2 0.1 0.0043 17.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK46179.1 - 0.0026 17.9 0.2 0.0098 16.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK46179.1 - 0.031 14.7 1.4 0.14 12.5 0.2 2.5 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.11 PIK46179.1 - 0.032 14.2 0.7 3.4 7.7 0.1 2.4 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Cu-oxidase PF00394.22 PIK46181.1 - 1.7e-23 83.5 0.0 1.5e-22 80.5 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK46181.1 - 2.1e-12 47.1 0.1 1.7e-11 44.1 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 PIK46182.1 - 1.8e-32 112.0 4.5 2e-27 95.6 0.1 3.3 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK46182.1 - 3.1e-29 101.4 2.2 2e-28 98.8 0.3 3.1 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 PIK46182.1 - 9.1e-22 77.9 0.0 2.8e-21 76.3 0.0 1.9 1 0 0 1 1 1 1 Multicopper oxidase IFT20 PF14931.6 PIK46183.1 - 5.8e-50 168.4 10.2 6.5e-50 168.3 10.2 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 AAA_13 PF13166.6 PIK46183.1 - 0.014 14.1 5.4 0.017 13.8 5.4 1.0 1 0 0 1 1 1 0 AAA domain DUF1045 PF06299.12 PIK46183.1 - 0.016 15.2 0.9 0.069 13.1 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1045) TACC_C PF05010.14 PIK46183.1 - 0.035 13.9 10.9 0.062 13.1 10.9 1.4 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Syntaxin-6_N PF09177.11 PIK46183.1 - 0.054 14.1 3.3 0.45 11.1 3.3 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF3846 PF12957.7 PIK46183.1 - 0.06 13.7 0.1 0.11 12.9 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3846) MethyTransf_Reg PF10119.9 PIK46183.1 - 0.079 13.7 0.5 0.19 12.5 0.5 1.6 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain PepX_N PF09168.10 PIK46183.1 - 0.26 11.7 5.3 0.55 10.6 1.4 2.1 1 1 0 2 2 2 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal YabA PF06156.13 PIK46183.1 - 0.32 11.6 4.8 0.44 11.2 4.3 1.5 1 1 0 1 1 1 0 Initiation control protein YabA DUF2781 PF10914.8 PIK46184.1 - 2.3e-11 44.3 0.4 3.1e-11 43.9 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF2781 PF10914.8 PIK46185.1 - 9e-23 81.3 4.9 9.9e-23 81.2 4.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Ifi-6-16 PF06140.13 PIK46186.1 - 2.7e-12 46.4 24.9 1.6e-11 43.9 25.6 1.7 1 1 1 2 2 2 2 Interferon-induced 6-16 family GH3 PF03321.13 PIK46187.1 - 3.9e-35 121.7 0.5 3.1e-21 75.8 0.7 2.0 2 0 0 2 2 2 2 GH3 auxin-responsive promoter LRR_8 PF13855.6 PIK46188.1 - 3.3e-39 132.5 23.5 2.9e-13 49.3 7.1 5.9 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK46188.1 - 3e-19 68.8 35.8 0.00011 22.5 1.2 8.1 6 1 0 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK46188.1 - 3e-13 49.8 2.7 7.5e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK46188.1 - 9.9e-08 31.7 10.3 0.0001 21.8 0.3 4.3 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 PIK46188.1 - 6.2e-06 26.1 28.8 4.2 8.3 0.0 10.7 10 1 0 10 10 10 2 Leucine Rich Repeat Reeler PF02014.16 PIK46189.1 - 8.9e-18 65.3 0.1 9.9e-18 65.1 0.1 1.0 1 0 0 1 1 1 1 Reeler domain PMR5N PF14416.6 PIK46189.1 - 0.16 12.3 0.1 0.31 11.4 0.0 1.4 2 0 0 2 2 2 0 PMR5 N terminal Domain EGF PF00008.27 PIK46190.1 - 2.2e-24 85.4 34.8 1.2e-09 38.3 6.0 3.2 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK46190.1 - 1.1e-14 54.5 35.8 4.4e-06 27.1 3.0 4.5 5 0 0 5 5 5 3 Human growth factor-like EGF EGF_3 PF12947.7 PIK46190.1 - 1e-07 32.0 27.5 0.031 14.5 3.4 3.9 2 2 1 3 3 3 3 EGF domain EGF_2 PF07974.13 PIK46190.1 - 9.7e-06 25.8 38.8 0.0073 16.7 8.5 3.3 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 PIK46190.1 - 1.3e-05 25.3 35.0 0.0025 18.0 13.2 3.4 2 1 1 3 3 3 2 Calcium-binding EGF domain Laminin_EGF PF00053.24 PIK46190.1 - 3.6e-05 23.8 29.9 0.043 14.0 3.5 3.4 2 1 1 3 3 3 3 Laminin EGF domain FXa_inhibition PF14670.6 PIK46190.1 - 0.0027 17.9 28.9 0.12 12.6 5.5 3.4 1 1 2 3 3 3 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK46190.1 - 0.086 12.8 37.4 0.27 11.2 0.2 5.3 4 2 0 4 4 4 0 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 PIK46190.1 - 0.13 12.5 24.3 0.57 10.5 1.4 3.4 3 0 0 3 3 3 0 Pvs28 EGF domain EGF PF00008.27 PIK46191.1 - 4.4e-52 173.9 189.1 2.1e-07 31.1 8.5 13.5 13 0 0 13 13 13 12 EGF-like domain hEGF PF12661.7 PIK46191.1 - 3.6e-24 84.5 171.7 8.3e-06 26.2 7.3 15.2 15 0 0 15 15 15 11 Human growth factor-like EGF EGF_2 PF07974.13 PIK46191.1 - 9.3e-15 54.7 201.6 0.006 16.9 10.0 13.2 13 1 0 13 13 13 11 EGF-like domain CUB PF00431.20 PIK46191.1 - 2.3e-14 53.6 0.0 5.4e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 CUB domain EGF_CA PF07645.15 PIK46191.1 - 0.0076 16.4 11.8 0.0076 16.4 11.8 14.0 5 3 8 13 13 13 4 Calcium-binding EGF domain LEA_2 PF03168.13 PIK46192.1 - 4.8 7.8 7.8 14 6.3 3.6 2.8 2 1 1 3 3 3 0 Late embryogenesis abundant protein SUR7 PF06687.12 PIK46194.1 - 1.8e-06 27.7 0.0 0.0015 18.2 0.0 2.3 2 0 0 2 2 2 2 SUR7/PalI family Claudin_2 PF13903.6 PIK46194.1 - 2.8e-06 27.2 2.9 0.0057 16.4 0.0 2.2 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction PHO4 PF01384.20 PIK46194.1 - 1.5e-05 24.3 0.0 0.008 15.3 0.0 2.0 2 0 0 2 2 2 2 Phosphate transporter family Gaa1 PF04114.14 PIK46194.1 - 3.3e-05 23.1 2.0 0.0071 15.4 0.0 2.1 2 0 0 2 2 2 2 Gaa1-like, GPI transamidase component OATP PF03137.20 PIK46194.1 - 9e-05 21.0 0.0 0.35 9.1 0.0 2.4 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Pex24p PF06398.11 PIK46194.1 - 0.00026 20.1 0.0 0.3 10.0 0.0 2.3 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin DUF2207 PF09972.9 PIK46194.1 - 0.0023 16.8 0.0 0.26 10.0 0.0 2.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) 7tm_1 PF00001.21 PIK46194.1 - 0.0061 15.9 7.0 0.3 10.4 0.0 2.2 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Tetraspanin PF00335.20 PIK46194.1 - 0.0076 16.0 0.0 0.95 9.1 0.0 2.6 2 0 0 2 2 2 1 Tetraspanin family CBP_BcsG PF11658.8 PIK46194.1 - 0.015 13.7 7.7 0.61 8.4 0.3 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Wzy_C PF04932.15 PIK46194.1 - 0.024 14.3 0.0 2.2 7.9 0.0 2.2 2 0 0 2 2 2 0 O-Antigen ligase Shisa PF13908.6 PIK46194.1 - 0.025 14.8 1.0 0.14 12.4 0.2 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator S_4TM PF18159.1 PIK46194.1 - 0.074 12.4 3.8 3.5 6.9 1.5 2.3 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain TctB PF07331.11 PIK46194.1 - 0.21 11.9 7.4 0.082 13.2 0.3 2.2 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family MgtE PF01769.16 PIK46194.1 - 0.66 10.4 31.8 0.21 12.0 6.5 2.1 2 0 0 2 2 2 0 Divalent cation transporter DUF4448 PF14610.6 PIK46194.1 - 5.3 6.8 6.6 2.8 7.7 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4448) PhoLip_ATPase_C PF16212.5 PIK46194.1 - 5.6 6.6 25.1 2 8.1 10.2 2.1 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Pkinase PF00069.25 PIK46195.1 - 2.7e-59 200.7 0.0 7.2e-59 199.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46195.1 - 2.7e-21 76.0 0.0 6e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK46195.1 - 1.9e-06 27.4 0.0 4.9e-06 26.1 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK46195.1 - 7e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 PIK46195.1 - 0.0011 18.6 0.3 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase FTA2 PF13095.6 PIK46195.1 - 0.0058 16.3 0.1 0.49 10.0 0.0 2.6 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Ku_N PF03731.15 PIK46195.1 - 0.034 13.9 2.2 0.11 12.2 2.5 1.7 2 0 0 2 2 2 0 Ku70/Ku80 N-terminal alpha/beta domain APH PF01636.23 PIK46195.1 - 0.086 12.7 0.1 0.29 11.0 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family EF-hand_9 PF14658.6 PIK46195.1 - 0.15 12.4 1.9 1.4 9.3 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain Glyoxalase PF00903.25 PIK46196.1 - 8.7e-25 87.4 1.6 7.3e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 PIK46196.1 - 1.1e-14 54.7 0.3 6.6e-09 36.0 0.3 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 PIK46196.1 - 3.2e-06 27.4 0.2 0.059 13.5 0.1 2.9 3 1 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 PIK46196.1 - 0.0063 16.7 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal ACOX PF01756.19 PIK46197.1 - 8.5e-47 159.0 0.5 4.4e-45 153.4 0.0 2.6 2 1 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 PIK46197.1 - 2.5e-06 27.8 0.0 3.2e-05 24.2 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK46197.1 - 5.3e-05 23.3 0.2 0.039 14.2 0.1 2.5 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, middle domain Neur_chan_LBD PF02931.23 PIK46198.1 - 1.4e-55 188.0 4.4 2.2e-55 187.5 4.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK46198.1 - 8.4e-33 114.4 4.8 1.1e-32 114.0 4.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 PIK46199.1 - 1.1e-08 35.5 0.0 1.3e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region RT_RNaseH_2 PF17919.1 PIK46200.1 - 7.4e-34 115.8 0.0 1.4e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46200.1 - 1.1e-32 112.4 0.0 2e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46201.1 - 7.7e-16 58.3 0.0 1.5e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK46201.1 - 0.0034 17.5 0.0 0.0054 16.9 0.0 1.3 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) Rad1 PF02144.16 PIK46202.1 - 1.7e-79 266.7 3.5 2.1e-79 266.4 3.5 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 KR PF08659.10 PIK46202.1 - 0.14 12.0 0.1 0.22 11.4 0.1 1.2 1 0 0 1 1 1 0 KR domain CUE PF02845.16 PIK46203.1 - 2.1e-09 36.9 0.1 5.9e-09 35.5 0.1 1.7 2 0 0 2 2 2 1 CUE domain DMA PF03474.14 PIK46203.1 - 0.036 13.7 0.0 0.088 12.4 0.0 1.6 1 0 0 1 1 1 0 DMRTA motif U3_snoRNA_assoc PF08297.11 PIK46203.1 - 6.5 7.5 11.3 1 10.1 2.9 3.0 3 0 0 3 3 3 0 U3 snoRNA associated ERM PF00769.19 PIK46204.1 - 1.8e-30 106.5 32.6 1.8e-30 106.5 32.6 2.0 2 0 0 2 2 2 1 Ezrin/radixin/moesin family ChapFlgA PF13144.6 PIK46204.1 - 0.35 10.9 4.9 0.94 9.6 0.5 2.5 2 0 0 2 2 2 0 Chaperone for flagella basal body P-ring formation FERM_M PF00373.18 PIK46205.1 - 3.7e-26 91.9 4.2 5.3e-26 91.3 4.2 1.3 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 PIK46205.1 - 2.3e-13 50.3 0.1 3.4e-12 46.6 0.0 2.4 2 1 0 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.10 PIK46205.1 - 5.3e-13 48.7 1.7 7.9e-13 48.2 0.2 2.1 3 0 0 3 3 3 1 FERM N-terminal domain Rep_fac-A_C PF08646.10 PIK46206.1 - 2.9e-37 127.7 9.6 1.6e-35 122.0 5.3 3.3 2 2 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 PIK46206.1 - 2e-32 111.0 2.4 4.7e-32 109.8 0.9 2.2 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 PIK46206.1 - 4.7e-12 45.8 0.0 1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 PIK46206.1 - 7.2e-12 45.1 0.7 1e-10 41.4 0.1 2.6 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain POT1 PF02765.17 PIK46206.1 - 0.0039 17.0 1.0 0.2 11.5 0.0 2.7 3 0 0 3 3 3 1 Telomeric single stranded DNA binding POT1/CDC13 DUF223 PF02721.14 PIK46206.1 - 0.04 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF223 IBR PF01485.21 PIK46206.1 - 0.05 13.8 2.7 0.11 12.7 1.5 2.1 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DUF4539 PF15072.6 PIK46206.1 - 0.077 13.0 0.0 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) EGF_CA PF07645.15 PIK46206.1 - 0.28 11.4 3.3 0.86 9.9 3.3 1.8 1 0 0 1 1 1 0 Calcium-binding EGF domain zf-AN1 PF01428.16 PIK46206.1 - 1.9 8.7 7.7 0.16 12.1 2.3 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger ZNRF_3_ecto PF18212.1 PIK46207.1 - 1.8e-14 53.6 0.1 4.1e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 ZNRF-3 Ectodomain zf-RING_2 PF13639.6 PIK46207.1 - 6.9e-14 51.9 6.8 6.9e-14 51.9 6.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 PIK46207.1 - 8e-11 41.5 4.3 2.6e-10 39.9 4.3 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK46207.1 - 1.2e-10 41.0 5.5 2.8e-10 39.9 5.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK46207.1 - 1e-08 34.9 4.8 2.4e-08 33.7 4.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK46207.1 - 3.5e-08 33.6 10.3 1.7e-07 31.4 8.8 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK46207.1 - 1.1e-05 25.3 3.7 3.4e-05 23.8 3.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK46207.1 - 2e-05 24.4 3.7 5.4e-05 23.1 3.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK46207.1 - 0.00015 21.6 2.1 0.00032 20.5 2.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK46207.1 - 0.00016 21.4 6.3 0.00018 21.3 4.7 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 PIK46207.1 - 0.0054 16.8 4.3 0.015 15.4 4.3 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4381 PF14316.6 PIK46207.1 - 0.016 15.5 0.3 0.029 14.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) BatD PF13584.6 PIK46207.1 - 0.06 12.1 0.1 0.086 11.6 0.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance FANCL_C PF11793.8 PIK46207.1 - 0.068 13.3 4.9 0.064 13.4 3.0 2.1 2 1 0 2 2 1 0 FANCL C-terminal domain DUF2500 PF10694.9 PIK46207.1 - 0.11 13.0 0.2 0.23 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) RINGv PF12906.7 PIK46207.1 - 0.12 12.6 3.6 0.32 11.1 3.6 1.8 1 1 0 1 1 1 0 RING-variant domain EphA2_TM PF14575.6 PIK46207.1 - 0.12 13.2 0.1 0.27 12.2 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 PIK46207.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TRAP_alpha PF03896.16 PIK46207.1 - 0.13 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RSN1_TM PF13967.6 PIK46207.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport NicO PF03824.16 PIK46207.1 - 0.24 10.7 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein YajC PF02699.15 PIK46207.1 - 0.36 10.7 1.4 0.88 9.5 1.4 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit PHD PF00628.29 PIK46207.1 - 0.54 10.2 4.4 1 9.3 4.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.5 PIK46207.1 - 0.77 9.8 4.9 2.1 8.4 4.9 1.8 1 0 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 PIK46207.1 - 0.94 9.5 5.0 0.93 9.5 1.7 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 PIK46207.1 - 1.3 9.4 4.3 3.1 8.2 4.3 1.6 1 0 0 1 1 1 0 RING-like domain FAD_binding_1 PF00667.20 PIK46209.1 - 1.2e-49 168.9 0.0 2e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 PIK46209.1 - 4e-11 43.5 0.0 1.1e-10 42.1 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 PIK46211.1 - 5.8e-30 104.4 0.0 7.6e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin NO_synthase PF02898.15 PIK46211.1 - 0.0011 18.0 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain NO_synthase PF02898.15 PIK46212.1 - 7.1e-30 104.3 0.0 8.2e-30 104.1 0.0 1.0 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain Pkinase PF00069.25 PIK46213.1 - 1e-64 218.4 0.0 1.8e-64 217.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46213.1 - 3.6e-36 124.8 0.0 6.2e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK46213.1 - 0.00039 19.8 0.0 0.00074 18.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK46213.1 - 0.0017 17.2 2.4 0.0023 16.8 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 PIK46213.1 - 0.0024 17.8 0.1 0.013 15.4 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK46213.1 - 0.024 13.6 0.0 0.049 12.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK46213.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Filament PF00038.21 PIK46213.1 - 2.5 7.6 10.2 0.093 12.3 1.6 2.2 2 0 0 2 2 2 0 Intermediate filament protein Arm PF00514.23 PIK46215.1 - 2e-06 27.7 1.2 0.1 12.7 0.0 4.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK46215.1 - 2e-06 28.2 1.1 0.002 18.6 0.1 3.5 2 1 1 3 3 3 2 HEAT-like repeat HEAT PF02985.22 PIK46215.1 - 5e-06 26.3 0.4 0.053 13.8 0.1 4.0 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 PIK46215.1 - 3.2e-05 24.2 0.2 0.0023 18.3 0.1 3.1 1 1 1 2 2 2 1 HEAT repeats F-box-like PF12937.7 PIK46216.1 - 0.012 15.5 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 F-box-like LRR_6 PF13516.6 PIK46216.1 - 0.098 12.8 0.2 2.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 PIK46216.1 - 0.17 12.4 0.8 1 9.9 0.1 2.2 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) WD40 PF00400.32 PIK46217.1 - 2.3e-09 37.7 3.1 0.015 16.2 0.1 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK46217.1 - 1.9e-06 28.1 0.1 1.4 9.3 0.0 5.5 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain ELYS-bb PF16687.5 PIK46217.1 - 0.066 11.8 0.0 1.5 7.3 0.0 2.1 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin ELM2 PF01448.24 PIK46218.1 - 1.2e-06 29.2 2.1 2.7e-06 28.1 0.0 2.6 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 PIK46218.1 - 0.00071 19.7 0.4 0.0024 18.0 0.4 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK46218.1 - 0.041 13.8 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Myb DNA-binding like RrnaAD PF00398.20 PIK46219.1 - 3.2e-63 213.3 0.0 4.1e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 PIK46219.1 - 5.3e-08 33.5 0.0 1.1e-07 32.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK46219.1 - 4e-06 27.4 0.0 8.5e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK46219.1 - 2.7e-05 24.0 0.0 3.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 PIK46219.1 - 4.1e-05 24.3 0.0 7.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK46219.1 - 0.0014 18.2 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 PIK46219.1 - 0.0019 17.9 0.0 0.0045 16.6 0.0 1.6 2 0 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_18 PF12847.7 PIK46219.1 - 0.0065 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK46219.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 PIK46219.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK46219.1 - 0.019 14.8 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 PIK46219.1 - 0.03 13.8 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.6 PIK46219.1 - 0.039 13.8 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 PIK46219.1 - 0.041 13.6 0.1 0.069 12.9 0.1 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DREV PF05219.12 PIK46219.1 - 0.046 12.8 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase HCNGP PF07818.13 PIK46219.1 - 0.069 13.8 0.0 0.21 12.2 0.0 1.8 2 0 0 2 2 1 0 HCNGP-like protein PRMT5 PF05185.16 PIK46219.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase 7tm_1 PF00001.21 PIK46220.1 - 1.8e-32 112.7 21.2 2.2e-32 112.5 21.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK46220.1 - 3.5e-10 39.7 19.8 4.7e-10 39.3 19.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK46220.1 - 3.3e-05 23.7 15.8 3.3e-05 23.7 15.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Bac_export_2 PF01312.19 PIK46220.1 - 3.4e-05 23.2 2.5 6.8e-05 22.2 2.5 1.4 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family Adeno_E3_CR2 PF02439.15 PIK46220.1 - 0.0056 16.4 0.2 0.0056 16.4 0.2 2.3 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 7tm_4 PF13853.6 PIK46220.1 - 0.018 14.8 19.1 0.17 11.6 0.3 3.1 2 1 0 2 2 2 0 Olfactory receptor fn3 PF00041.21 PIK46221.1 - 0.004 17.5 1.0 0.0087 16.4 0.3 1.9 2 0 0 2 2 2 1 Fibronectin type III domain DNase_II PF03265.15 PIK46222.1 - 7.2e-66 222.7 5.2 8.9e-66 222.4 5.2 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Retrotrans_gag PF03732.17 PIK46223.1 - 0.073 13.3 0.5 0.073 13.3 0.5 2.7 2 1 1 3 3 3 0 Retrotransposon gag protein RVT_1 PF00078.27 PIK46224.1 - 1.5e-10 41.0 0.0 0.00045 19.8 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK46224.1 - 0.0026 17.9 0.0 0.1 12.8 0.0 2.3 1 1 1 2 2 2 1 Spumavirus aspartic protease (A9) RT_RNaseH PF17917.1 PIK46225.1 - 5.6e-20 71.6 0.4 1.2e-19 70.5 0.4 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46225.1 - 3e-09 36.8 0.2 5e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK46226.1 - 6.2e-24 84.5 0.0 1.3e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK46226.1 - 0.012 15.3 2.1 0.012 15.3 0.0 2.2 3 0 0 3 3 3 0 Integrase core domain Transferrin PF00405.17 PIK46227.1 - 1.3e-23 83.7 1.6 1e-09 38.1 0.8 3.2 2 1 1 3 3 3 3 Transferrin WAP PF00095.21 PIK46227.1 - 4.7e-05 23.7 12.6 4.7e-05 23.7 12.6 3.2 2 1 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Phosphonate-bd PF12974.7 PIK46227.1 - 0.016 14.8 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF1833 PF08875.11 PIK46227.1 - 0.065 12.8 0.0 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) IFT57 PF10498.9 PIK46227.1 - 0.073 12.0 0.0 0.17 10.8 0.0 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Transferrin PF00405.17 PIK46228.1 - 2.2e-06 27.1 0.0 3.5e-06 26.4 0.0 1.3 1 1 0 1 1 1 1 Transferrin DUF4562 PF15123.6 PIK46230.1 - 4.2e-32 110.5 0.7 2.3e-30 104.9 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4562) Annexin PF00191.20 PIK46231.1 - 2e-96 316.1 14.2 3.9e-26 90.9 0.1 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 PIK46231.1 - 0.036 14.0 2.5 3.7 7.5 0.1 3.5 3 1 0 4 4 4 0 Myb DNA-binding like DUF2661 PF10860.8 PIK46231.1 - 0.26 11.4 0.5 9 6.5 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2661) SASA PF03629.18 PIK46232.1 - 8.8e-14 51.7 0.0 2.5e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 Carbohydrate esterase, sialic acid-specific acetylesterase SCAI PF12070.8 PIK46232.1 - 0.16 10.8 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein SCAI DegT_DnrJ_EryC1 PF01041.17 PIK46233.1 - 2.6e-15 56.6 0.1 6.5e-14 52.0 0.1 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 PIK46233.1 - 0.085 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Zein PF01559.16 PIK46234.1 - 2.9e-22 79.4 15.4 3.2e-11 43.3 4.1 2.8 1 1 0 2 2 2 2 Zein seed storage protein Adeno_E1B_55K PF01696.17 PIK46234.1 - 2.1e-13 49.8 3.6 0.25 10.0 0.0 6.6 1 1 6 7 7 7 7 Adenovirus EB1 55K protein / large t-antigen DUF3859 PF12975.7 PIK46234.1 - 0.067 13.2 11.4 6.4 6.8 0.1 5.3 1 1 5 6 6 6 0 Domain of unknown function (DUF3859) PG_binding_4 PF12229.8 PIK46234.1 - 2.6 8.4 25.3 8.8 6.6 0.4 6.1 2 1 3 7 7 7 0 Putative peptidoglycan binding domain Fil_haemagg PF05594.14 PIK46234.1 - 2.9 8.5 6.9 1.9e+02 2.7 2.5 4.6 2 2 0 2 2 2 0 Haemagluttinin repeat Smim3 PF17307.2 PIK46234.1 - 7.3 6.2 6.4 44 3.7 0.7 3.4 1 1 1 2 2 2 0 Small integral membrane protein 3 Ank_2 PF12796.7 PIK46235.1 - 1.1e-21 77.2 4.4 2.7e-07 31.1 0.5 4.0 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) DHHC PF01529.20 PIK46235.1 - 1.7e-21 76.8 9.9 1.7e-21 76.8 9.9 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 PIK46235.1 - 4.8e-19 68.2 0.9 4.7e-08 33.1 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK46235.1 - 1.5e-16 60.6 1.6 8.1e-10 39.0 0.0 3.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK46235.1 - 3.5e-15 55.7 2.1 0.00055 20.3 0.7 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 PIK46235.1 - 2.1e-12 46.1 6.3 0.0013 19.0 0.1 7.0 8 1 1 9 9 9 3 Ankyrin repeat GST_N PF02798.20 PIK46236.1 - 1.7e-10 41.1 0.0 2e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK46236.1 - 0.00046 20.5 0.0 0.00049 20.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GTP-bdg_M PF16360.5 PIK46236.1 - 0.014 16.0 0.0 0.014 16.0 0.0 1.1 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region GST_N_2 PF13409.6 PIK46236.1 - 0.037 14.3 0.0 0.045 14.1 0.0 1.1 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK46237.1 - 5e-18 65.1 0.0 6.9e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK46237.1 - 6.8e-10 39.0 0.0 1.1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK46237.1 - 2.1e-08 34.4 0.0 1.4e-07 31.8 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK46237.1 - 3.2e-06 27.0 0.0 4.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK46237.1 - 0.00057 20.3 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK46237.1 - 0.0019 17.9 0.0 0.0037 17.0 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK46237.1 - 0.002 18.4 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK46238.1 - 1.1e-14 54.5 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK46238.1 - 6.5e-07 29.6 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK46238.1 - 3.2e-05 24.1 0.0 5.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK46238.1 - 0.0012 18.9 0.0 0.0029 17.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK46238.1 - 0.1 12.4 0.1 0.32 10.8 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK46238.1 - 0.11 13.0 0.0 0.28 11.6 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK46239.1 - 7.7e-18 64.5 0.0 1.2e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK46239.1 - 1.9e-08 34.5 0.0 4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK46239.1 - 2.6e-07 30.8 0.0 3.7e-07 30.3 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK46239.1 - 0.00057 20.2 0.0 0.00094 19.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK46239.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 PIK46239.1 - 0.11 13.2 0.0 0.21 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain PTPLA PF04387.14 PIK46240.1 - 0.05 13.3 0.6 0.05 13.3 0.6 2.3 3 0 0 3 3 3 0 Protein tyrosine phosphatase-like protein, PTPLA Tetraspanin PF00335.20 PIK46241.1 - 5.8e-47 160.3 9.8 7.2e-47 160.0 9.8 1.0 1 0 0 1 1 1 1 Tetraspanin family Med18 PF09637.10 PIK46242.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Med18 protein GCFC PF07842.12 PIK46242.1 - 0.063 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein zf-CDGSH PF09360.10 PIK46243.1 - 7.6e-11 42.1 0.6 1.1e-10 41.5 0.6 1.3 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type zf-C2H2_4 PF13894.6 PIK46244.1 - 1.9e-14 53.1 63.7 0.0018 18.9 2.0 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK46244.1 - 2.1e-13 49.9 67.2 4.1e-05 23.8 4.0 8.5 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK46244.1 - 4e-13 49.1 67.7 2.5e-06 27.7 1.4 9.4 9 0 0 9 9 9 4 Zinc-finger double domain NPL PF17800.1 PIK46244.1 - 1.2e-10 41.9 0.2 5.4e-10 39.8 0.0 2.3 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-C2H2_6 PF13912.6 PIK46244.1 - 0.00031 20.7 2.8 0.00031 20.7 2.8 7.1 7 0 0 7 7 7 2 C2H2-type zinc finger DUF3268 PF11672.8 PIK46244.1 - 0.044 14.1 16.9 0.23 11.8 1.1 3.5 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.8 PIK46244.1 - 0.48 10.8 52.7 0.34 11.2 0.8 8.1 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-CHCC PF10276.9 PIK46244.1 - 0.53 10.4 8.4 0.48 10.5 0.4 3.8 3 0 0 3 3 3 0 Zinc-finger domain BolA PF01722.18 PIK46244.1 - 0.98 9.7 5.1 2.6 8.4 0.1 3.0 3 0 0 3 3 3 0 BolA-like protein Peptidase_M10 PF00413.24 PIK46245.1 - 4.3e-44 150.2 0.0 8.3e-44 149.2 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK46245.1 - 4.3e-29 100.2 20.1 1.4e-10 41.0 2.1 4.6 4 0 0 4 4 4 4 Hemopexin Peptidase_M66 PF10462.9 PIK46245.1 - 0.0011 18.0 0.1 0.0017 17.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase M66 PG_binding_1 PF01471.18 PIK46245.1 - 0.0018 18.5 0.1 0.0049 17.1 0.1 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Metallopep PF12044.8 PIK46245.1 - 0.0044 15.7 0.0 0.0064 15.1 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family DUF4953 PF16313.5 PIK46245.1 - 0.006 15.8 0.1 0.0091 15.2 0.1 1.2 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.6 PIK46245.1 - 0.019 15.4 0.4 0.036 14.6 0.4 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK46245.1 - 0.032 13.9 0.1 0.06 13.0 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK46245.1 - 0.032 14.4 0.2 0.06 13.5 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 PIK46245.1 - 0.2 11.6 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Astacin PF01400.24 PIK46245.1 - 0.27 10.8 0.3 0.97 9.0 0.0 1.9 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) zf-H2C2_2 PF13465.6 PIK46246.1 - 3e-68 223.4 109.8 9.8e-09 35.3 2.3 13.7 14 0 0 14 14 13 12 Zinc-finger double domain zf-C2H2 PF00096.26 PIK46246.1 - 4.4e-44 146.5 113.7 1.1e-05 25.6 0.4 13.3 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK46246.1 - 6.8e-33 110.5 106.8 0.0019 18.9 0.2 13.2 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK46246.1 - 2.6e-17 62.6 74.6 0.0029 17.8 1.4 12.7 12 1 0 12 12 12 8 Zinc-finger double-stranded RNA-binding C1_1 PF00130.22 PIK46246.1 - 6.7e-07 29.1 58.9 0.0052 16.6 2.5 8.3 1 1 7 9 9 9 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.7 PIK46246.1 - 0.0004 20.7 82.7 0.11 12.9 2.0 13.1 13 0 0 13 13 13 6 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK46246.1 - 0.0024 18.6 53.4 3.9 8.3 0.7 7.1 5 1 1 7 7 7 5 zinc-ribbon family DUF2180 PF09947.9 PIK46246.1 - 0.003 17.5 1.6 0.003 17.5 1.6 5.1 4 4 1 5 5 4 1 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_11 PF16622.5 PIK46246.1 - 0.0051 16.5 0.0 0.0051 16.5 0.0 10.5 13 0 0 13 13 12 4 zinc-finger C2H2-type Elf1 PF05129.13 PIK46246.1 - 0.0081 16.2 3.3 0.0081 16.2 3.3 8.3 1 1 8 9 9 9 2 Transcription elongation factor Elf1 like PyrI_C PF02748.15 PIK46246.1 - 0.013 15.3 57.3 0.5 10.3 0.2 11.2 10 3 3 13 13 13 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-DNA_Pol PF08996.10 PIK46246.1 - 0.014 15.1 0.7 0.014 15.1 0.7 6.2 1 1 3 5 5 5 0 DNA Polymerase alpha zinc finger zf-Di19 PF05605.12 PIK46246.1 - 0.017 15.4 72.3 0.11 12.9 1.0 9.6 4 1 3 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 PIK46246.1 - 0.048 13.8 67.4 0.79 9.9 1.8 10.0 5 4 7 12 12 12 0 Zinc ribbon domain XPA_N PF01286.18 PIK46246.1 - 0.39 10.8 0.0 0.39 10.8 0.0 11.6 13 0 0 13 13 13 0 XPA protein N-terminal zf_UBZ PF18439.1 PIK46246.1 - 0.72 9.5 40.6 4.9 6.8 0.1 10.2 10 0 0 10 10 10 0 Ubiquitin-Binding Zinc Finger DUF4524 PF15025.6 PIK46246.1 - 1.3 8.7 9.1 0.39 10.4 2.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4524) DUF3268 PF11672.8 PIK46246.1 - 1.6 9.1 38.3 0.095 13.0 1.3 6.7 2 1 3 8 8 8 0 zinc-finger-containing domain FYDLN_acid PF09538.10 PIK46246.1 - 5.6 7.7 25.8 23 5.7 0.1 8.1 3 3 7 10 10 10 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_9 PF14369.6 PIK46246.1 - 6.2 7.2 37.0 16 5.9 0.1 9.9 11 0 0 11 11 11 0 zinc-ribbon Peptidase_M2 PF01401.18 PIK46247.1 - 1e-84 285.2 0.0 1.3e-84 284.9 0.0 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme PHB_acc_N PF07879.11 PIK46247.1 - 0.14 12.3 0.1 0.45 10.6 0.1 1.8 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain COesterase PF00135.28 PIK46248.1 - 1e-27 97.2 0.2 1.2e-27 97.0 0.2 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK46248.1 - 0.028 14.1 3.4 0.028 14.1 3.4 2.8 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK46249.1 - 6.7e-70 236.4 0.1 7.7e-70 236.2 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK46249.1 - 4.8e-09 36.4 1.0 2.8e-08 33.9 1.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK46249.1 - 0.0047 17.5 0.2 0.0064 17.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Fasciclin PF02469.22 PIK46250.1 - 8e-56 187.7 1.1 1.6e-27 96.2 0.5 2.1 2 0 0 2 2 2 2 Fasciclin domain Exo_endo_phos PF03372.23 PIK46251.1 - 6.8e-05 22.5 0.0 0.00012 21.7 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MOSC_N PF03476.16 PIK46252.1 - 2.1e-25 89.0 0.0 1.5e-21 76.5 0.0 2.5 2 0 0 2 2 2 2 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 PIK46252.1 - 5.9e-25 88.0 0.0 5.5e-15 55.2 0.0 2.6 2 1 0 2 2 2 2 Aminotransferase class-V MOSC PF03473.17 PIK46252.1 - 3.7e-19 69.1 0.0 9.2e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 MOSC domain PNP_UDP_1 PF01048.20 PIK46253.1 - 5.8e-26 91.2 0.1 7.2e-26 90.9 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Cyclin_C_2 PF16899.5 PIK46254.1 - 8.2e-24 84.0 0.0 1.5e-22 79.9 0.0 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 PIK46254.1 - 2.1e-10 40.5 0.1 4.2e-10 39.4 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain RB_B PF01857.20 PIK46254.1 - 0.002 18.2 0.1 0.0042 17.1 0.1 1.7 1 1 0 1 1 1 1 Retinoblastoma-associated protein B domain TFIIB PF00382.19 PIK46254.1 - 0.004 17.2 0.0 0.012 15.6 0.0 1.8 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Aminotran_5 PF00266.19 PIK46255.1 - 4.4e-46 157.5 0.0 5.9e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK46255.1 - 9.9e-09 34.8 0.0 6.7e-08 32.1 0.1 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II Peptidase_M2 PF01401.18 PIK46256.1 - 1.8e-214 713.6 2.3 3.2e-214 712.8 2.3 1.4 1 1 0 1 1 1 1 Angiotensin-converting enzyme hEGF PF12661.7 PIK46257.1 - 4.2e-07 30.3 9.5 0.0029 18.2 3.0 3.7 2 1 0 2 2 2 2 Human growth factor-like EGF EGF_CA PF07645.15 PIK46257.1 - 5.7e-07 29.6 11.1 5.7e-07 29.6 11.1 3.3 2 1 0 2 2 2 1 Calcium-binding EGF domain EGF PF00008.27 PIK46257.1 - 1.6e-05 25.1 18.7 0.00019 21.6 4.7 3.1 3 0 0 3 3 3 2 EGF-like domain EGF_3 PF12947.7 PIK46257.1 - 0.043 14.0 21.5 0.055 13.7 5.1 2.7 2 0 0 2 2 2 0 EGF domain SEA PF01390.20 PIK46257.1 - 0.054 13.6 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 SEA domain RVT_1 PF00078.27 PIK46259.1 - 7.5e-09 35.4 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2590 PF10761.9 PIK46260.1 - 5.2e-12 45.8 0.1 0.14 12.3 0.0 5.2 1 1 3 5 5 5 4 Protein of unknown function (DUF2590) DUF4884 PF16225.5 PIK46260.1 - 7.5e-06 25.9 10.3 63 3.7 0.0 8.6 8 1 1 9 9 9 0 Domain of unknown function (DUF4884) DUF4624 PF15417.6 PIK46260.1 - 0.0054 16.5 1.7 11 5.9 0.1 4.0 1 1 2 4 4 4 2 Domain of unknown function (DUF4624) DUF2880 PF11082.8 PIK46260.1 - 0.022 15.1 17.9 15 6.0 0.4 6.0 1 1 7 8 8 8 0 Protein of unknown function (DUF2880) UPF0253 PF06786.12 PIK46260.1 - 0.24 11.7 3.7 75 3.7 0.1 4.5 1 1 5 6 6 6 0 Uncharacterised protein family (UPF0253) Fibrinogen_C PF00147.18 PIK46261.1 - 4.1e-44 151.0 2.1 6.3e-44 150.4 2.1 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46261.1 - 1.5e-05 25.1 16.5 3.9e-05 23.7 14.0 2.4 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK46261.1 - 1.5e-05 24.9 4.0 2.9e-05 23.9 4.0 1.5 1 0 0 1 1 1 1 TILa domain EGF_MSP1_1 PF12946.7 PIK46261.1 - 0.003 17.6 3.3 0.003 17.6 3.3 1.8 2 0 0 2 2 2 1 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK46261.1 - 0.0093 16.3 7.5 0.026 14.9 7.5 1.9 1 1 0 1 1 1 1 EGF-like domain Fibrinogen_C PF00147.18 PIK46262.1 - 1.2e-31 110.3 2.0 1.7e-31 109.7 2.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK46262.1 - 4.3e-07 29.8 14.4 4.3e-07 29.8 14.4 2.7 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK46262.1 - 0.00012 22.1 13.7 0.00012 22.1 13.7 2.8 2 0 0 2 2 2 1 EGF domain VWC PF00093.18 PIK46262.1 - 0.3 11.4 18.0 3.3 8.1 18.0 2.2 1 1 0 1 1 1 0 von Willebrand factor type C domain Fibrinogen_C PF00147.18 PIK46263.1 - 2.4e-30 106.0 1.3 4.5e-30 105.1 1.3 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK46263.1 - 2e-07 31.2 11.7 2e-07 31.2 11.7 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK46263.1 - 3.4e-06 26.9 12.5 3.4e-06 26.9 12.5 3.8 2 2 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK46263.1 - 1.6e-05 25.0 12.3 1.6e-05 25.0 12.3 4.1 3 1 1 4 4 4 1 EGF domain hEGF PF12661.7 PIK46263.1 - 0.0049 17.5 1.9 0.0049 17.5 1.9 5.2 5 1 0 5 5 5 1 Human growth factor-like EGF EGF PF00008.27 PIK46263.1 - 0.03 14.6 9.9 0.03 14.6 9.9 4.4 4 1 0 4 4 4 0 EGF-like domain Tme5_EGF_like PF09064.10 PIK46263.1 - 0.031 14.2 8.1 0.031 14.2 8.1 3.6 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Calcyon PF06387.11 PIK46263.1 - 2.3 8.1 5.0 0.29 11.1 0.7 1.6 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) Fibrinogen_C PF00147.18 PIK46264.1 - 1.4e-32 113.3 9.6 1.9e-32 112.8 9.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46264.1 - 1.9e-06 27.9 14.0 1.9e-06 27.9 14.0 3.1 3 0 0 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK46264.1 - 5.3e-05 23.2 8.3 5.3e-05 23.2 8.3 2.1 2 0 0 2 2 2 1 MSP1 EGF domain 1 TILa PF12714.7 PIK46264.1 - 0.00013 21.9 12.9 0.00013 21.9 12.9 2.6 2 0 0 2 2 2 1 TILa domain IGR PF09597.10 PIK46265.1 - 0.023 14.8 0.9 7.8 6.7 0.2 3.0 3 0 0 3 3 3 0 IGR protein motif Peptidase_U49 PF10463.9 PIK46265.1 - 0.076 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Peptidase U49 DUF2783 PF10932.8 PIK46265.1 - 0.16 11.7 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) C2-set_2 PF08205.12 PIK46266.1 - 1.1e-05 25.4 0.7 0.011 15.8 0.2 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ly49 PF08391.10 PIK46266.1 - 0.00055 20.3 0.3 0.011 16.1 0.0 3.0 2 0 0 2 2 2 1 Ly49-like protein, N-terminal region DUF2561 PF10812.8 PIK46266.1 - 0.021 14.9 0.0 0.034 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) ACDC PF14733.6 PIK46266.1 - 0.043 14.1 0.9 0.26 11.6 0.1 2.6 2 0 0 2 2 2 0 AP2-coincident C-terminal TMEM154 PF15102.6 PIK46266.1 - 0.061 13.2 0.2 0.17 11.8 0.2 1.7 1 0 0 1 1 1 0 TMEM154 protein family AveC_like PF17198.4 PIK46266.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Spirocyclase AveC-like ig PF00047.25 PIK46266.1 - 0.081 13.1 3.5 17 5.7 0.0 4.9 5 0 0 5 5 5 0 Immunoglobulin domain EF-hand_1 PF00036.32 PIK46267.1 - 5.1e-12 44.4 1.7 1.3e-05 24.4 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK46267.1 - 5.4e-11 41.5 1.1 8.7e-05 22.1 0.2 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK46267.1 - 5.6e-11 41.4 2.0 1.6e-06 27.3 0.8 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK46267.1 - 5.7e-10 39.5 1.2 5.7e-10 39.5 1.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK46267.1 - 3.5e-05 23.6 3.6 0.00017 21.4 1.6 2.7 2 1 1 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 PIK46267.1 - 0.038 14.2 0.5 0.14 12.4 0.0 2.2 2 0 0 2 2 1 0 Dockerin type I domain DUF641 PF04859.12 PIK46267.1 - 0.043 14.1 29.0 0.19 12.1 1.1 3.8 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) PikAIV_N PF18605.1 PIK46267.1 - 0.22 11.1 6.0 0.071 12.7 1.0 2.5 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain KASH_CCD PF14662.6 PIK46267.1 - 0.41 10.4 39.0 1.8 8.4 4.5 2.9 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH CENP-Q PF13094.6 PIK46267.1 - 0.59 10.3 31.2 3.4 7.9 20.6 2.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.11 PIK46267.1 - 3.2 6.5 41.6 2.4 6.9 22.4 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein FUSC PF04632.12 PIK46267.1 - 4.5 5.7 16.2 7.1 5.0 16.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 PIK46267.1 - 5.2 7.1 17.7 1.5 8.9 5.4 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 PIK46267.1 - 5.8 6.6 38.8 0.083 12.6 22.1 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 PIK46267.1 - 5.8 7.3 39.5 1.4 9.3 8.5 4.0 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.9 PIK46267.1 - 7.1 6.8 48.2 0.64 10.2 15.8 3.6 2 1 2 4 4 3 0 JNK_SAPK-associated protein-1 DUF4795 PF16043.5 PIK46267.1 - 7.7 6.1 31.3 10 5.6 19.2 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4795) DUF4472 PF14739.6 PIK46267.1 - 8.9 7.1 38.9 3.4 8.4 14.9 4.4 2 1 3 5 5 5 0 Domain of unknown function (DUF4472) DASH_Dam1 PF08653.10 PIK46267.1 - 8.9 6.2 14.0 41 4.1 0.0 4.9 5 0 0 5 5 5 0 DASH complex subunit Dam1 DASH_Duo1 PF08651.10 PIK46267.1 - 9.7 6.1 16.0 0.41 10.5 1.2 4.0 4 0 0 4 4 4 0 DASH complex subunit Duo1 Death PF00531.22 PIK46268.1 - 1.4e-15 57.2 2.8 2.5e-15 56.4 2.8 1.4 1 0 0 1 1 1 1 Death domain DUF87 PF01935.17 PIK46268.1 - 0.012 15.7 1.6 0.29 11.2 0.1 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain Rab5-bind PF09311.11 PIK46268.1 - 0.039 13.3 1.5 0.058 12.8 1.5 1.3 1 0 0 1 1 1 0 Rabaptin-like protein CARD_2 PF16739.5 PIK46268.1 - 0.14 12.2 1.1 0.26 11.3 1.1 1.4 1 0 0 1 1 1 0 Caspase recruitment domain RE_AlwI PF09491.10 PIK46269.1 - 0.0079 15.0 1.0 0.013 14.4 1.0 1.2 1 0 0 1 1 1 1 AlwI restriction endonuclease zf-C2HC_2 PF13913.6 PIK46269.1 - 0.014 15.3 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 PIK46269.1 - 0.16 12.5 0.9 2.1 8.9 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK46269.1 - 1.1 10.3 3.2 1.4 9.9 0.6 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger CCDC50_N PF15295.6 PIK46270.1 - 0.0034 17.5 0.6 0.0054 16.9 0.6 1.4 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 50 N-terminus DUF728 PF05304.12 PIK46270.1 - 8 6.3 7.1 18 5.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF728) rve PF00665.26 PIK46271.1 - 2.1e-21 76.3 0.0 8.1e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK46271.1 - 0.0088 16.3 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve_3 PF13683.6 PIK46271.1 - 0.0089 15.8 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK46272.1 - 4.6e-15 55.8 0.1 8.2e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46272.1 - 7e-08 32.4 0.2 1.8e-06 27.9 0.0 2.4 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase YgaB PF14182.6 PIK46273.1 - 0.19 12.1 0.0 73 3.9 0.0 3.0 3 0 0 3 3 3 0 YgaB-like protein Bowman-Birk_leg PF00228.20 PIK46273.1 - 3.8 8.0 6.0 40 4.7 0.1 3.3 3 0 0 3 3 3 0 Bowman-Birk serine protease inhibitor family PXA PF02194.15 PIK46274.1 - 1.4e-26 93.6 0.3 3.7e-26 92.2 0.3 1.7 1 0 0 1 1 1 1 PXA domain PX PF00787.24 PIK46274.1 - 1.1e-13 51.2 2.3 4.3e-13 49.2 2.3 2.1 1 0 0 1 1 1 1 PX domain Nexin_C PF08628.12 PIK46274.1 - 6.1e-13 49.3 0.0 1.4e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 Sorting nexin C terminal RGS PF00615.19 PIK46274.1 - 1.8e-11 44.3 2.0 5e-11 42.9 2.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain bMG5 PF17972.1 PIK46274.1 - 0.054 13.9 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG5 domain PXA PF02194.15 PIK46275.1 - 0.025 14.5 0.1 0.04 13.9 0.1 1.3 1 0 0 1 1 1 0 PXA domain PMM PF03332.13 PIK46276.1 - 2.7e-61 207.2 0.4 3e-61 207.0 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase CD20 PF04103.15 PIK46277.1 - 1.8e-12 47.6 7.5 2.3e-12 47.3 7.5 1.2 1 0 0 1 1 1 1 CD20-like family Tetraspanin PF00335.20 PIK46277.1 - 9e-05 22.3 3.4 9e-05 22.3 3.4 1.9 1 1 1 2 2 2 1 Tetraspanin family DHHC PF01529.20 PIK46277.1 - 0.0063 16.6 3.6 0.0071 16.5 0.4 2.0 1 1 2 3 3 3 1 DHHC palmitoyltransferase Ninjurin PF04923.12 PIK46277.1 - 0.063 13.2 1.9 0.08 12.9 0.1 2.0 2 0 0 2 2 2 0 Ninjurin TMEM52 PF14979.6 PIK46277.1 - 0.1 12.5 4.5 1 9.3 0.0 2.9 3 0 0 3 3 3 0 Transmembrane 52 L6_membrane PF05805.12 PIK46277.1 - 0.11 12.0 14.0 0.3 10.7 0.1 2.7 2 1 1 3 3 3 0 L6 membrane protein DUF3112 PF11309.8 PIK46277.1 - 0.25 10.8 4.3 0.59 9.5 2.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3112) DUF4173 PF13777.6 PIK46277.1 - 0.51 9.7 5.4 0.26 10.7 2.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4173) Neurensin PF14927.6 PIK46277.1 - 0.55 9.9 8.8 0.87 9.3 0.3 2.5 1 1 1 2 2 2 0 Neurensin Cytochrom_B558a PF05038.13 PIK46277.1 - 0.84 9.2 6.7 0.71 9.4 0.8 2.6 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit Sigma_reg_N PF13800.6 PIK46277.1 - 2.4 8.5 6.5 4.5 7.6 0.5 2.9 2 1 1 3 3 3 0 Sigma factor regulator N-terminal DUF3899 PF13038.6 PIK46277.1 - 2.8 8.5 5.6 18 5.9 0.8 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF3899) CSD PF00313.22 PIK46278.1 - 1.8e-08 34.1 0.0 2.4e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 PIK46278.1 - 0.033 13.9 0.1 0.065 12.9 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain RVT_1 PF00078.27 PIK46281.1 - 7.3e-30 104.1 0.0 1.2e-29 103.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46281.1 - 4.9e-21 75.1 0.0 9.6e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46281.1 - 4.5e-19 68.3 0.1 8.4e-19 67.4 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46281.1 - 0.00026 20.7 0.0 0.00083 19.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.6 PIK46281.1 - 0.0054 17.3 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 PIK46281.1 - 0.012 15.9 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 PIK46281.1 - 0.021 15.4 0.0 0.048 14.3 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Elongin_A PF06881.11 PIK46281.1 - 0.074 13.6 0.2 6.4 7.4 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A HSP70 PF00012.20 PIK46282.1 - 2.4e-10 39.2 7.0 2.7e-10 39.1 7.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Lon_2 PF13337.6 PIK46282.1 - 0.024 13.2 0.5 0.026 13.1 0.5 1.0 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease Z1 PF10593.9 PIK46282.1 - 0.22 11.0 3.0 0.24 10.9 3.0 1.0 1 0 0 1 1 1 0 Z1 domain HSP70 PF00012.20 PIK46283.1 - 1.3e-104 350.5 0.1 1.5e-104 350.4 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK46283.1 - 2.1e-05 23.5 0.0 2.7e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 MreB/Mbl protein Pox_D5 PF03288.16 PIK46283.1 - 0.16 12.4 0.0 1.4 9.5 0.1 2.1 2 0 0 2 2 2 0 Poxvirus D5 protein-like Exo_endo_phos_2 PF14529.6 PIK46284.1 - 6.8e-07 29.2 0.1 1.2e-06 28.3 0.1 1.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK46284.1 - 0.024 14.2 0.0 0.042 13.4 0.0 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family CSN7a_helixI PF18392.1 PIK46284.1 - 0.27 11.2 2.9 0.65 9.9 0.1 2.4 2 0 0 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain HSP70 PF00012.20 PIK46285.1 - 2.4e-241 802.1 16.3 2.8e-241 801.9 16.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK46285.1 - 1.7e-17 63.3 0.2 4e-16 58.8 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 PIK46285.1 - 0.0012 18.7 0.0 0.0063 16.3 0.0 2.2 3 0 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 PIK46285.1 - 0.0025 18.2 4.6 0.78 10.2 0.0 3.3 3 1 0 3 3 3 2 Cell division protein FtsA MetOD2 PF18548.1 PIK46285.1 - 0.041 14.0 0.1 0.041 14.0 0.1 2.8 3 0 0 3 3 3 0 Metanogen output domain 2 DUF3535 PF12054.8 PIK46285.1 - 0.079 12.2 2.3 1.4 8.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3535) Z1 PF10593.9 PIK46285.1 - 0.44 10.0 8.0 1.2 8.6 5.8 2.3 2 0 0 2 2 2 0 Z1 domain HSP70 PF00012.20 PIK46286.1 - 1.7e-06 26.5 3.7 1.9e-06 26.4 3.7 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF4294 PF14127.6 PIK46286.1 - 0.055 13.4 1.1 0.063 13.2 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) V_ATPase_I PF01496.19 PIK46287.1 - 3.5e-270 898.5 2.3 4.7e-199 663.2 1.5 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family Cyt_bd_oxida_II PF02322.15 PIK46287.1 - 1.3 8.3 16.3 0.34 10.2 5.3 3.1 3 0 0 3 3 3 0 Cytochrome bd terminal oxidase subunit II LRR_4 PF12799.7 PIK46288.1 - 5.1e-05 23.5 0.0 0.0014 18.9 0.0 2.4 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK46288.1 - 5.7e-05 22.9 0.7 0.16 12.1 0.0 3.5 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 PIK46288.1 - 0.0068 16.8 0.0 22 6.1 0.0 3.9 4 0 0 4 4 4 1 Leucine Rich Repeat Adenine_deam_C PF13382.6 PIK46288.1 - 0.034 13.5 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain DUF1699 PF08004.11 PIK46288.1 - 0.06 13.0 0.2 0.65 9.7 0.1 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1699) Mito_carr PF00153.27 PIK46289.1 - 1.9e-38 130.3 1.6 1e-20 73.4 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Ras PF00071.22 PIK46290.1 - 5.5e-21 74.9 0.0 7.3e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK46290.1 - 0.0054 17.0 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK46290.1 - 0.0054 16.2 0.0 0.0066 15.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Kunitz_BPTI PF00014.23 PIK46291.1 - 4.2e-16 58.9 9.2 4.4e-16 58.8 9.2 1.0 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Membralin PF09746.9 PIK46293.1 - 1.1e-160 534.9 0.1 1.6e-160 534.3 0.1 1.2 1 0 0 1 1 1 1 Tumour-associated protein VWA_2 PF13519.6 PIK46294.1 - 0.035 14.7 0.0 0.069 13.8 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Sulfotransfer_3 PF13469.6 PIK46295.1 - 0.026 14.9 0.0 0.037 14.4 0.0 1.3 1 1 0 1 1 1 0 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK46296.1 - 0.049 14.0 0.0 0.078 13.3 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family RVT_1 PF00078.27 PIK46298.1 - 2.1e-17 63.4 0.0 3.4e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Toprim_N PF08275.11 PIK46298.1 - 0.086 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 DNA primase catalytic core, N-terminal domain Y_phosphatase PF00102.27 PIK46299.1 - 7.8e-43 146.7 0.9 1.1e-42 146.2 0.9 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK46299.1 - 0.01 15.9 0.1 0.029 14.5 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate DSPc PF00782.20 PIK46299.1 - 0.022 14.5 0.1 0.063 13.1 0.1 1.8 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK46300.1 - 5.4e-16 58.7 3.9 1.9e-07 31.3 0.5 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK46300.1 - 4.1e-05 24.1 6.6 0.041 14.4 0.3 2.7 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK46300.1 - 0.0012 19.2 0.0 0.28 11.5 0.0 2.3 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III Y_phosphatase PF00102.27 PIK46301.1 - 3.1e-20 72.8 0.8 3.8e-20 72.5 0.8 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK46302.1 - 1.7e-16 60.3 3.7 4.7e-08 33.3 0.6 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK46302.1 - 1e-05 26.0 4.9 0.025 15.2 0.3 2.8 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK46302.1 - 0.0093 16.3 0.0 1.9 8.9 0.0 2.4 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III DUF4989 PF16379.5 PIK46302.1 - 0.058 12.7 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4989) Y_phosphatase PF00102.27 PIK46303.1 - 1.3e-20 74.0 0.6 2.1e-19 70.0 0.6 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DUF3504 PF12012.8 PIK46305.1 - 2.3e-19 69.9 0.3 3.7e-19 69.2 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) Y_phosphatase PF00102.27 PIK46306.1 - 4.2e-86 288.3 4.0 1.5e-53 181.8 0.6 2.0 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK46306.1 - 1.2e-14 54.3 0.4 5.1e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK46306.1 - 1.9e-07 31.3 0.0 0.002 18.1 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK46306.1 - 3.3e-07 30.6 0.1 0.00045 20.4 0.0 3.2 3 1 0 3 3 3 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK46306.1 - 0.00013 21.6 0.9 0.0019 17.8 0.1 2.7 3 0 0 3 3 3 1 Tyrosine phosphatase family CDKN3 PF05706.12 PIK46306.1 - 0.05 13.3 0.0 4.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) fn3 PF00041.21 PIK46307.1 - 1.1e-12 48.1 1.3 3e-08 33.9 0.4 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK46307.1 - 7.5e-05 23.2 0.9 0.025 15.1 0.4 2.4 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain CHB_HEX_C_1 PF13290.6 PIK46307.1 - 0.2 11.7 5.3 0.9 9.6 5.3 2.1 1 1 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Y_phosphatase PF00102.27 PIK46308.1 - 1.6e-40 139.1 0.0 3.3e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase NTPase_P4 PF11602.8 PIK46308.1 - 0.052 12.8 0.0 0.11 11.6 0.0 1.5 2 0 0 2 2 2 0 ATPase P4 of dsRNA bacteriophage phi-12 Ig_3 PF13927.6 PIK46309.1 - 0.00057 20.4 1.3 0.036 14.7 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK46309.1 - 0.0096 16.2 0.6 0.039 14.3 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK46309.1 - 0.011 16.1 0.9 0.071 13.5 0.0 2.5 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK46309.1 - 0.029 14.4 0.0 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain V-set PF07686.17 PIK46309.1 - 0.033 14.4 1.3 0.13 12.5 0.0 2.4 2 2 0 2 2 2 0 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK46309.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Y_phosphatase PF00102.27 PIK46311.1 - 7.2e-51 173.0 2.3 1.5e-50 172.0 2.3 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK46311.1 - 1.9e-29 101.8 16.7 5.2e-07 29.9 0.1 5.4 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK46311.1 - 2.1e-11 44.2 18.8 0.00027 21.4 0.0 6.1 5 2 0 5 5 5 5 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK46311.1 - 0.00019 21.7 0.1 11 6.4 0.1 5.1 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III fn3_4 PF16794.5 PIK46311.1 - 0.0075 16.2 0.7 1.6 8.7 0.0 4.5 5 1 0 5 5 5 1 Fibronectin-III type domain RVT_1 PF00078.27 PIK46311.1 - 0.023 14.2 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) fn3_2 PF16893.5 PIK46311.1 - 0.073 13.2 0.3 2.1 8.6 0.1 3.1 3 0 0 3 3 3 0 Fibronectin type III domain EGF_CA PF07645.15 PIK46312.1 - 2.4e-19 69.3 40.6 9.5e-07 28.9 4.0 4.3 3 1 1 4 4 4 3 Calcium-binding EGF domain cEGF PF12662.7 PIK46312.1 - 6.5e-11 42.0 20.1 7.2e-06 25.8 1.7 4.4 3 1 1 4 4 4 2 Complement Clr-like EGF-like Lectin_C PF00059.21 PIK46312.1 - 7.7e-08 33.0 0.0 1.4e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain FXa_inhibition PF14670.6 PIK46312.1 - 1.2e-05 25.5 32.8 0.016 15.4 5.4 4.5 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK46312.1 - 0.0061 16.7 35.8 0.011 15.9 4.2 5.0 3 2 1 4 4 4 3 EGF domain EGF PF00008.27 PIK46312.1 - 0.0086 16.4 5.3 0.0086 16.4 5.3 4.6 4 1 0 4 4 4 3 EGF-like domain hEGF PF12661.7 PIK46312.1 - 0.079 13.6 36.4 0.27 11.9 2.7 6.1 5 1 0 5 5 5 0 Human growth factor-like EGF Fis1_TPR_C PF14853.6 PIK46313.1 - 0.00021 21.3 0.5 0.0004 20.4 0.5 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat DARPP-32 PF05395.12 PIK46313.1 - 0.047 13.9 19.9 0.27 11.5 0.3 2.4 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 FAS_N PF17828.1 PIK46313.1 - 0.13 12.3 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta SGT1 PF07093.11 PIK46313.1 - 0.66 8.4 14.0 0.94 7.8 14.0 1.3 1 0 0 1 1 1 0 SGT1 protein Nop14 PF04147.12 PIK46313.1 - 4 5.5 30.8 5.5 5.1 30.8 1.2 1 0 0 1 1 1 0 Nop14-like family GGACT PF06094.12 PIK46314.1 - 6e-06 26.9 0.0 6.9e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like CDV3 PF15359.6 PIK46315.1 - 5.4e-26 91.6 7.9 5.4e-26 91.6 7.9 1.7 2 0 0 2 2 2 1 Carnitine deficiency-associated protein 3 GGACT PF06094.12 PIK46316.1 - 1e-18 68.1 0.0 1.2e-18 67.8 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK46316.1 - 0.0038 17.6 0.1 0.011 16.1 0.1 1.8 1 1 0 1 1 1 1 AIG2-like family MH1 PF03165.16 PIK46317.1 - 3.5e-39 133.1 2.9 4.7e-39 132.7 2.9 1.2 1 0 0 1 1 1 1 MH1 domain DUF2458 PF10454.9 PIK46317.1 - 0.035 13.7 0.1 0.045 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF5054 PF16477.5 PIK46317.1 - 0.071 12.9 0.0 0.09 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5054) MIP-T3_C PF17749.1 PIK46318.1 - 1.4e-47 161.5 12.4 1.4e-47 161.5 12.4 3.1 2 1 1 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region MIP-T3 PF10243.9 PIK46318.1 - 2.3e-47 159.6 0.4 2.3e-47 159.6 0.4 1.9 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 CH-like domain Tup_N PF08581.10 PIK46318.1 - 4.5 7.6 11.4 1.1 9.6 3.2 3.0 2 1 0 2 2 2 0 Tup N-terminal SAC3_GANP PF03399.16 PIK46319.1 - 2.6e-80 270.0 5.1 3.6e-80 269.5 5.1 1.2 1 0 0 1 1 1 1 SAC3/GANP family FoP_duplication PF13865.6 PIK46320.1 - 5.1e-12 46.2 55.6 1.6e-05 25.4 55.6 4.1 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 HMG_box PF00505.19 PIK46321.1 - 4.8e-18 65.3 0.6 4.8e-18 65.3 0.6 2.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK46321.1 - 5.7e-06 26.8 0.2 5.7e-06 26.8 0.2 2.2 2 0 0 2 2 2 1 HMG-box domain Vps5 PF09325.10 PIK46321.1 - 0.12 11.9 6.4 0.25 10.9 6.4 1.4 1 0 0 1 1 1 0 Vps5 C terminal like FapA PF03961.13 PIK46321.1 - 1.1 7.8 3.2 2.6 6.5 1.5 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Staphylokinase PF02821.16 PIK46323.1 - 0.015 15.7 0.1 0.036 14.5 0.1 1.6 1 0 0 1 1 1 0 Staphylokinase/Streptokinase family Binary_toxB_2 PF17475.2 PIK46323.1 - 0.55 9.9 8.9 1.9 8.1 1.3 2.2 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA domain 2 EGF_CA PF07645.15 PIK46326.1 - 1.2e-108 355.1 361.5 1.6e-09 37.8 8.5 24.3 20 3 4 24 24 24 21 Calcium-binding EGF domain EGF_3 PF12947.7 PIK46326.1 - 8.1e-68 224.3 322.0 6.1e-09 35.9 7.6 24.1 21 2 3 24 24 24 16 EGF domain cEGF PF12662.7 PIK46326.1 - 6e-59 195.5 242.9 1.1e-09 38.1 2.5 25.0 25 0 0 25 25 25 17 Complement Clr-like EGF-like EGF PF00008.27 PIK46326.1 - 1.5e-25 89.2 303.3 1.4e-05 25.3 4.0 26.1 23 2 1 24 24 24 18 EGF-like domain FXa_inhibition PF14670.6 PIK46326.1 - 4.7e-19 68.4 307.1 1.2e-07 31.8 5.0 24.9 16 6 8 24 24 24 12 Coagulation Factor Xa inhibitory site NIDO PF06119.14 PIK46326.1 - 6.9e-15 55.8 2.5 2.8e-14 53.8 0.5 3.1 3 0 0 3 3 3 1 Nidogen-like hEGF PF12661.7 PIK46326.1 - 1.5e-13 50.8 259.0 0.00047 20.7 2.1 29.1 28 2 0 28 28 28 15 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK46326.1 - 5.2e-10 39.2 236.8 7.8e-06 25.8 6.0 20.5 20 1 1 21 21 21 10 MSP1 EGF domain 1 Ldl_recept_a PF00057.18 PIK46326.1 - 0.001 19.2 4.6 0.001 19.2 4.6 15.4 18 0 0 18 18 18 2 Low-density lipoprotein receptor domain class A DUF4064 PF13273.6 PIK46327.1 - 0.0014 18.9 0.1 0.0027 18.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF1514 PF07438.11 PIK46327.1 - 0.064 13.1 0.4 0.17 11.8 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) Ly49 PF08391.10 PIK46327.1 - 0.1 12.9 1.2 0.28 11.5 0.9 1.8 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region EphA2_TM PF14575.6 PIK46327.1 - 0.13 13.1 0.0 0.28 12.1 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Tmemb_9 PF05434.11 PIK46327.1 - 0.14 12.0 0.4 0.67 9.8 0.0 2.2 2 0 0 2 2 2 0 TMEM9 Smim3 PF17307.2 PIK46327.1 - 0.21 11.1 1.5 0.35 10.4 1.5 1.3 1 0 0 1 1 1 0 Small integral membrane protein 3 Exo_endo_phos_2 PF14529.6 PIK46328.1 - 0.057 13.3 3.4 0.2 11.5 0.0 3.1 3 1 1 4 4 4 0 Endonuclease-reverse transcriptase IspD PF01128.19 PIK46329.1 - 8.9e-25 87.7 0.0 2.1e-24 86.5 0.0 1.5 1 1 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_3 PF12804.7 PIK46329.1 - 3.3e-06 27.5 0.0 5.3e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 PIK46329.1 - 0.0023 17.6 0.0 0.0023 17.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase CTP_transf_3 PF02348.19 PIK46329.1 - 0.0037 17.2 0.0 0.005 16.8 0.0 1.3 1 1 0 1 1 1 1 Cytidylyltransferase Gal-3-0_sulfotr PF06990.11 PIK46330.1 - 2.8e-26 92.4 0.9 3.5e-26 92.0 0.9 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK46330.1 - 0.0013 19.1 0.2 0.0088 16.4 0.1 2.2 1 1 1 2 2 2 1 Sulfotransferase family MFS_1 PF07690.16 PIK46331.1 - 2.3e-09 36.6 8.4 4e-09 35.9 0.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2198 PF09964.9 PIK46331.1 - 0.85 9.7 6.2 0.31 11.1 2.6 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) MFS_1 PF07690.16 PIK46332.1 - 3.1e-18 65.8 8.8 3.1e-18 65.8 8.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2198 PF09964.9 PIK46332.1 - 0.13 12.4 2.1 0.52 10.4 2.1 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) DUF543 PF04418.12 PIK46332.1 - 0.8 9.7 4.2 0.99 9.4 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF543) PITH PF06201.13 PIK46333.1 - 1.2e-40 139.2 1.3 1.8e-40 138.6 1.3 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 PIK46333.1 - 9e-20 70.6 0.6 1.6e-19 69.8 0.6 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 PIK46333.1 - 0.00014 21.4 0.1 0.00019 20.9 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 PIK46333.1 - 0.031 14.6 0.1 1.1 9.6 0.1 2.4 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK46333.1 - 0.033 14.6 0.1 0.074 13.5 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain TFA2_Winged_2 PF18121.1 PIK46334.1 - 1.8e-08 33.9 0.0 3.4e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 PIK46334.1 - 0.014 15.7 0.3 0.034 14.4 0.2 1.7 1 1 0 1 1 1 0 TFIIE beta subunit core domain AWPM-19 PF05512.11 PIK46334.1 - 0.022 15.0 0.2 0.035 14.3 0.2 1.2 1 0 0 1 1 1 0 AWPM-19-like family Methyltransf_25 PF13649.6 PIK46335.1 - 1.6e-11 44.7 0.1 4.6e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 PIK46335.1 - 9e-10 38.4 0.0 1.3e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 PIK46335.1 - 9.1e-09 35.9 0.2 3.6e-08 33.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK46335.1 - 3.6e-08 33.3 0.0 5.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK46335.1 - 8.3e-06 25.4 0.1 1.3e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 PIK46335.1 - 1.3e-05 25.8 0.0 0.00011 22.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 PIK46335.1 - 4.3e-05 22.6 0.1 5.5e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 PIK46335.1 - 5.5e-05 23.1 0.0 0.00015 21.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 PIK46335.1 - 0.00016 21.6 0.1 0.00023 21.2 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 PIK46335.1 - 0.0039 16.5 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain TehB PF03848.14 PIK46335.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_24 PF13578.6 PIK46335.1 - 0.026 15.5 0.0 0.047 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 PIK46335.1 - 0.033 13.9 0.1 0.054 13.2 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PRMT5 PF05185.16 PIK46335.1 - 0.039 13.8 0.1 0.063 13.1 0.1 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 PIK46335.1 - 0.06 13.2 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Cons_hypoth95 PF03602.15 PIK46335.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CMAS PF02353.20 PIK46335.1 - 0.084 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK46335.1 - 0.088 12.6 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 PIK46335.1 - 0.099 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 PIK46335.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein AAA_9 PF12781.7 PIK46336.1 - 2.1e-61 206.8 7.4 3.9e-60 202.7 3.8 3.2 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK46336.1 - 6.2e-38 130.2 0.0 1.4e-37 129.0 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK46336.1 - 6.3e-37 126.3 0.0 1e-34 119.2 0.1 2.6 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain Dynein_C PF18199.1 PIK46336.1 - 6.7e-20 71.5 0.2 6.7e-20 71.5 0.2 1.8 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_6 PF12774.7 PIK46337.1 - 1.1e-100 336.8 0.0 3.2e-100 335.3 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK46337.1 - 8.7e-86 288.5 1.6 2.2e-64 218.1 0.0 5.4 5 1 1 6 6 6 2 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK46337.1 - 6.5e-39 133.8 0.7 1.3e-36 126.3 0.0 4.1 4 1 1 5 5 4 1 P-loop containing dynein motor region D4 DHC_N1 PF08385.12 PIK46337.1 - 3.4e-36 125.0 1.0 3.4e-36 125.0 1.0 3.5 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 PIK46337.1 - 1.3e-32 112.6 0.0 2.1e-14 53.7 0.0 5.8 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK46337.1 - 1.3e-27 96.5 0.7 3e-23 82.3 0.0 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_16 PF13191.6 PIK46337.1 - 2.8e-11 44.1 4.7 0.028 14.8 0.0 6.1 5 1 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 PIK46337.1 - 2.1e-10 41.0 1.3 0.0016 18.7 0.0 5.1 4 0 0 4 4 4 2 AAA domain AAA PF00004.29 PIK46337.1 - 1.9e-05 25.1 1.1 1.1 9.6 0.0 5.1 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 PIK46337.1 - 8.6e-05 23.1 7.2 0.0077 16.7 0.0 4.3 5 0 0 5 5 3 2 ABC transporter AAA_24 PF13479.6 PIK46337.1 - 0.00013 21.8 1.0 0.032 13.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 PIK46337.1 - 0.00016 21.4 0.4 0.14 11.8 0.1 3.6 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 PIK46337.1 - 0.00022 21.2 0.2 0.054 13.4 0.0 3.8 4 0 0 4 4 4 1 RsgA GTPase Rad17 PF03215.15 PIK46337.1 - 0.00072 19.5 0.3 0.39 10.6 0.0 3.9 4 0 0 4 4 4 1 Rad17 P-loop domain MT PF12777.7 PIK46337.1 - 0.0016 17.6 6.2 0.021 13.9 0.4 2.3 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_18 PF13238.6 PIK46337.1 - 0.0024 18.4 1.7 0.46 11.0 0.0 4.3 4 0 0 4 4 2 1 AAA domain T2SSE PF00437.20 PIK46337.1 - 0.0045 16.1 0.0 0.04 13.0 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Sigma54_activat PF00158.26 PIK46337.1 - 0.005 16.6 0.0 9.7 5.9 0.0 3.4 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 PIK46337.1 - 0.0081 15.9 0.0 0.3 10.8 0.0 3.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_19 PF13245.6 PIK46337.1 - 0.017 15.4 0.8 23 5.3 0.0 4.1 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 PIK46337.1 - 0.019 15.4 0.4 3 8.3 0.0 3.6 3 0 0 3 3 3 0 RNA helicase YqzH PF14164.6 PIK46337.1 - 0.037 14.1 1.3 12 6.0 0.0 4.4 3 0 0 3 3 3 0 YqzH-like protein AAA_lid_1 PF17857.1 PIK46337.1 - 0.04 14.1 0.2 0.15 12.3 0.0 2.1 2 0 0 2 2 1 0 AAA+ lid domain ATPase_2 PF01637.18 PIK46337.1 - 0.068 13.1 2.7 2.5 7.9 0.0 3.6 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 PIK46337.1 - 0.11 11.7 0.0 2.1 7.6 0.1 2.9 3 0 0 3 3 3 0 Zeta toxin Arg_decarbox_C PF17944.1 PIK46337.1 - 0.25 11.9 3.1 0.51 10.9 0.2 3.3 2 0 0 2 2 1 0 Arginine decarboxylase C-terminal helical extension Fusion_gly PF00523.18 PIK46337.1 - 0.27 9.5 1.3 8.9 4.4 0.0 2.3 2 0 0 2 2 2 0 Fusion glycoprotein F0 AAA_33 PF13671.6 PIK46337.1 - 5 7.3 6.4 1.9 8.6 0.1 3.5 4 0 0 4 4 4 0 AAA domain Glyco_hydro_31 PF01055.26 PIK46338.1 - 1.4e-144 482.6 6.0 2e-144 482.0 6.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK46338.1 - 1.2e-31 109.3 0.1 2.2e-31 108.4 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase CCDC106 PF15794.5 PIK46339.1 - 1.9 8.2 6.8 3.4 7.3 6.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Macoilin PF09726.9 PIK46339.1 - 9.9 4.6 7.5 9 4.7 7.5 1.1 1 0 0 1 1 1 0 Macoilin family PBP1_TM PF14812.6 PIK46340.1 - 0.25 11.8 5.4 2.6 8.5 1.8 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AF-4 PF05110.13 PIK46342.1 - 3.5e-69 234.1 5.4 5.1e-69 233.6 5.4 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF1180 PF06679.12 PIK46342.1 - 0.03 14.7 0.8 0.043 14.2 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) NUDIX PF00293.28 PIK46343.1 - 1.9e-18 66.8 0.0 2.4e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain UPF0016 PF01169.19 PIK46345.1 - 2.5e-43 146.3 25.1 2.8e-22 78.8 5.4 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 PIK46345.1 - 0.0061 16.3 10.6 0.075 12.8 0.2 2.5 2 1 0 2 2 2 2 Putative manganese efflux pump Merozoite_SPAM PF07133.11 PIK46345.1 - 7.3 6.6 12.1 0.12 12.3 1.8 2.0 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) E1_DerP2_DerF2 PF02221.15 PIK46346.1 - 1.9e-15 57.5 1.5 2.7e-15 57.0 1.5 1.3 1 0 0 1 1 1 1 ML domain DUF1091 PF06477.13 PIK46346.1 - 1.2e-05 25.7 0.3 2.6e-05 24.6 0.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1091) RVT_1 PF00078.27 PIK46347.1 - 2.3e-27 96.0 0.0 5e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK46347.1 - 0.0034 17.0 0.0 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) NUDE_C PF04880.13 PIK46348.1 - 0.22 12.0 4.0 0.42 11.1 4.0 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Metallophos PF00149.28 PIK46349.1 - 2.1e-15 57.8 0.0 2.2e-15 57.7 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_7 PF13499.6 PIK46350.1 - 2.2e-19 69.7 0.6 3.4e-14 53.0 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK46350.1 - 2e-18 64.5 0.8 1.3e-05 24.4 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK46350.1 - 2.5e-16 58.1 0.2 0.00011 21.8 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 PIK46350.1 - 4.7e-12 45.6 0.8 2.8e-06 27.1 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK46350.1 - 2.7e-09 36.1 1.1 0.00023 20.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 PIK46350.1 - 0.00088 19.2 0.8 0.16 11.9 0.2 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Mpp10 PF04006.12 PIK46351.1 - 1.4e-10 40.3 20.6 1.8e-10 39.9 20.6 1.1 1 0 0 1 1 1 1 Mpp10 protein XRN_N PF03159.18 PIK46351.1 - 0.23 10.9 7.8 0.33 10.3 7.8 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus RVT_1 PF00078.27 PIK46352.1 - 1.2e-08 34.7 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK46353.1 - 9.8e-39 133.1 0.0 1.5e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIM5 PF17050.5 PIK46353.1 - 0.091 13.6 0.0 0.24 12.3 0.0 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria 5 Exo_endo_phos_2 PF14529.6 PIK46354.1 - 0.00074 19.3 1.0 0.19 11.6 0.0 2.8 2 1 1 3 3 3 2 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK46354.1 - 0.083 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF1770 PF08589.10 PIK46354.1 - 0.16 13.0 0.5 0.58 11.2 0.1 2.0 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1770) Alk_phosphatase PF00245.20 PIK46355.1 - 5e-100 335.4 0.0 5.6e-100 335.2 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 PIK46355.1 - 5.2e-08 32.5 0.2 9.8e-08 31.7 0.2 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 PIK46355.1 - 7.6e-05 22.4 0.1 0.0001 22.0 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK46355.1 - 0.00064 19.2 0.1 0.0041 16.6 0.1 2.1 1 1 0 1 1 1 1 Sulfatase AAA_5 PF07728.14 PIK46355.1 - 0.04 13.9 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Alk_phosphatase PF00245.20 PIK46356.1 - 2.1e-26 92.9 0.1 2.7e-26 92.5 0.1 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Mito_carr PF00153.27 PIK46358.1 - 1.9e-17 62.9 0.1 2.8e-17 62.4 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein Kunitz_legume PF00197.18 PIK46358.1 - 0.1 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Trypsin and protease inhibitor EF-hand_1 PF00036.32 PIK46359.1 - 1.4e-13 49.3 11.5 8e-08 31.3 0.6 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK46359.1 - 1.1e-10 40.6 1.9 0.00021 21.0 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK46359.1 - 1.3e-08 35.2 3.0 1.3e-08 35.2 3.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK46359.1 - 6.4e-06 25.4 5.4 0.00086 18.7 0.7 2.9 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 PIK46359.1 - 3e-05 24.3 0.5 3e-05 24.3 0.5 1.9 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 PIK46359.1 - 0.00022 21.0 7.5 0.00024 20.9 0.4 2.5 1 1 0 2 2 2 1 EF-hand domain pair Caleosin PF05042.13 PIK46359.1 - 0.0078 16.2 1.3 0.047 13.6 0.5 2.0 1 1 1 2 2 2 1 Caleosin related protein EF-hand_4 PF12763.7 PIK46359.1 - 0.051 13.5 2.3 2.9 7.9 0.1 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand FHA PF00498.26 PIK46360.1 - 2.6e-10 40.5 0.0 8.9e-10 38.8 0.0 2.0 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK46360.1 - 0.00014 22.1 1.2 0.0011 19.2 0.0 3.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain RVT_N PF13655.6 PIK46360.1 - 0.015 15.5 3.4 0.028 14.7 0.3 3.2 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase S6OS1 PF15676.5 PIK46361.1 - 2.1e-06 26.5 21.0 2.1e-06 26.5 21.0 2.0 2 0 0 2 2 2 1 Six6 opposite strand transcript 1 family DUF1759 PF03564.15 PIK46361.1 - 0.00056 19.9 9.9 0.00057 19.8 1.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1759) Neur_chan_memb PF02932.16 PIK46362.1 - 1.6e-34 120.0 0.1 2e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK46363.1 - 4.5e-47 160.3 5.0 5e-47 160.1 5.0 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain BTB_2 PF02214.22 PIK46364.1 - 6.6e-18 64.9 0.6 6.8e-17 61.6 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain SAM_Exu PF18609.1 PIK46364.1 - 0.084 13.0 0.0 0.6 10.2 0.0 2.1 2 0 0 2 2 2 0 Exuperantia SAM-like domain BTB_2 PF02214.22 PIK46365.1 - 1.1e-16 61.0 0.0 1.9e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK46365.1 - 0.02 15.1 0.0 0.028 14.6 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain BTB_2 PF02214.22 PIK46366.1 - 2.9e-18 66.0 0.0 5.1e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK46366.1 - 0.00021 21.5 0.0 0.00032 20.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 PIK46367.1 - 4.8e-17 62.1 0.1 1.2e-16 60.8 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Cupin_8 PF13621.6 PIK46368.1 - 8.4e-54 182.9 0.2 9.7e-54 182.7 0.2 1.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 PIK46368.1 - 0.026 14.9 0.0 0.064 13.7 0.0 1.7 2 0 0 2 2 2 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 PIK46368.1 - 0.062 12.8 0.2 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 Cupin superfamily protein Arrestin_N PF00339.29 PIK46369.1 - 3.3e-22 79.1 0.0 7.4e-21 74.7 0.0 2.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 PIK46369.1 - 2.8e-21 76.4 0.0 4.9e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain MoaF PF10703.9 PIK46369.1 - 0.079 12.9 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 MoaF N-terminal domain 7tm_1 PF00001.21 PIK46370.1 - 3.3e-41 141.4 7.3 4.2e-41 141.0 7.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK46370.1 - 3.3e-12 46.4 9.6 1.3e-07 31.2 2.8 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK46370.1 - 0.071 12.8 2.8 0.13 12.0 2.8 1.5 1 1 0 1 1 1 0 Olfactory receptor DUF3398 PF11878.8 PIK46370.1 - 0.17 12.3 0.4 0.47 10.9 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) Abhydrolase_1 PF00561.20 PIK46371.1 - 5.5e-15 55.7 0.0 6e-13 49.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK46371.1 - 3.6e-07 31.0 0.0 4.7e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK46371.1 - 0.066 12.5 0.0 0.14 11.4 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 LINES_N PF14694.6 PIK46372.1 - 7e-28 98.1 15.9 5e-27 95.3 7.9 2.5 1 1 2 3 3 3 2 Lines N-terminus LINES_C PF14695.6 PIK46372.1 - 5.4e-12 44.9 1.6 5.4e-12 44.9 1.6 2.6 3 0 0 3 3 3 1 Lines C-terminus CactinC_cactus PF09732.9 PIK46373.1 - 4.9e-58 194.5 8.8 9.3e-58 193.6 8.8 1.5 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 PIK46373.1 - 5e-40 137.4 11.6 2.4e-38 131.9 6.7 3.7 3 1 1 4 4 4 2 Conserved mid region of cactin SET PF00856.28 PIK46376.1 - 2.8e-22 79.9 0.4 7.1e-22 78.6 0.4 1.7 1 1 0 1 1 1 1 SET domain AWS PF17907.1 PIK46376.1 - 4.1e-17 61.9 9.2 4.1e-17 61.9 9.2 2.1 2 0 0 2 2 2 1 AWS domain RNA_pol_I_A49 PF06870.12 PIK46377.1 - 3.1e-32 111.9 0.8 3.6e-32 111.7 0.8 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor RNA_pol_I_A49 PF06870.12 PIK46378.1 - 1.2e-07 31.0 0.2 1.4e-07 30.8 0.2 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor IgGFc_binding PF17517.2 PIK46379.1 - 4.7e-12 45.8 0.1 1.5e-11 44.1 0.0 1.8 1 1 1 2 2 2 1 IgGFc binding protein IgGFc_binding PF17517.2 PIK46380.1 - 7.7e-11 41.8 0.3 4.4e-10 39.3 0.0 2.1 1 1 1 2 2 2 1 IgGFc binding protein Suppressor_P21 PF11479.8 PIK46380.1 - 0.11 12.8 0.1 9.8 6.5 0.0 2.7 2 0 0 2 2 2 0 RNA silencing suppressor P21 C-terminal domain 7tm_1 PF00001.21 PIK46381.1 - 1.1e-21 77.3 13.0 1.4e-21 77.0 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK46381.1 - 3.2e-08 33.3 13.3 4.9e-08 32.7 13.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 PIK46381.1 - 0.0058 16.4 1.3 0.0058 16.4 1.3 1.7 1 1 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 TauE PF01925.19 PIK46381.1 - 0.0077 15.9 0.2 0.018 14.7 0.2 1.6 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE TMEM154 PF15102.6 PIK46382.1 - 0.0024 17.8 0.1 0.0024 17.8 0.1 2.0 2 1 0 2 2 2 1 TMEM154 protein family Isy1 PF06246.12 PIK46382.1 - 0.013 15.0 3.6 0.013 15.0 3.6 1.8 2 0 0 2 2 2 0 Isy1-like splicing family DUF4064 PF13273.6 PIK46382.1 - 0.13 12.6 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) CSRNP_N PF16019.5 PIK46382.1 - 2.6 7.9 5.9 0.92 9.4 2.0 1.9 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus LRR_9 PF14580.6 PIK46383.1 - 1.3e-13 50.9 0.0 2e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 PIK46383.1 - 2.8e-05 23.8 0.9 0.0026 17.5 0.2 3.0 2 1 2 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 PIK46383.1 - 3.3e-05 24.1 10.1 0.0024 18.2 0.2 3.6 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK46383.1 - 2.7 8.3 0.0 2.7 8.3 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeat Circo_capsid PF02443.15 PIK46383.1 - 8.7 5.8 16.4 0.0094 15.6 3.7 2.1 2 0 0 2 2 2 0 Circovirus capsid protein CEP63 PF17045.5 PIK46384.1 - 0.00053 20.0 14.3 0.00061 19.8 14.3 1.1 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa DUF5082 PF16888.5 PIK46384.1 - 0.0058 16.9 10.1 0.0091 16.3 10.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) MukF_M PF17192.4 PIK46384.1 - 0.0064 16.3 5.3 0.0096 15.7 5.3 1.4 1 1 0 1 1 1 1 MukF middle domain GAS PF13851.6 PIK46384.1 - 0.0065 15.8 17.0 0.0073 15.7 17.0 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK46384.1 - 0.03 14.1 16.6 0.037 13.9 16.6 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3251 PF11622.8 PIK46384.1 - 0.031 13.9 2.5 0.036 13.7 1.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3251) PspA_IM30 PF04012.12 PIK46384.1 - 0.032 13.8 13.5 0.26 10.8 13.5 2.0 1 1 0 1 1 1 0 PspA/IM30 family Lip_prot_lig_C PF10437.9 PIK46384.1 - 0.035 14.1 0.2 0.067 13.2 0.2 1.6 1 1 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus TPR_MLP1_2 PF07926.12 PIK46384.1 - 0.035 14.2 17.9 0.046 13.8 17.9 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SlyX PF04102.12 PIK46384.1 - 0.042 14.5 2.6 0.042 14.5 2.6 2.8 1 1 1 2 2 2 0 SlyX LPP PF04728.13 PIK46384.1 - 0.058 13.8 7.3 0.39 11.1 2.5 2.7 2 1 1 3 3 2 0 Lipoprotein leucine-zipper SKA2 PF16740.5 PIK46384.1 - 0.073 12.9 9.9 0.44 10.3 3.5 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Prefoldin PF02996.17 PIK46384.1 - 0.079 12.9 0.9 0.079 12.9 0.9 2.4 1 1 0 2 2 2 0 Prefoldin subunit DivIC PF04977.15 PIK46384.1 - 0.084 12.7 13.0 0.17 11.6 3.4 2.2 1 1 0 2 2 2 0 Septum formation initiator FPP PF05911.11 PIK46384.1 - 0.09 11.0 15.1 0.098 10.8 15.1 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil ISG65-75 PF11727.8 PIK46384.1 - 0.1 11.8 7.2 0.11 11.7 7.2 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Fungal_TACC PF12709.7 PIK46384.1 - 0.11 12.9 9.3 0.13 12.8 2.8 2.2 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins SYCE1 PF15233.6 PIK46384.1 - 0.15 12.1 14.8 0.18 11.8 14.8 1.1 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 FlaC_arch PF05377.11 PIK46384.1 - 0.16 12.4 8.8 0.19 12.2 2.9 2.5 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 PIK46384.1 - 0.2 10.9 15.4 0.85 8.9 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 PIK46384.1 - 0.24 10.3 15.9 0.26 10.1 15.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ADIP PF11559.8 PIK46384.1 - 0.4 10.7 18.1 0.13 12.4 10.7 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DLP_helical PF18709.1 PIK46384.1 - 0.41 9.8 12.0 0.11 11.7 2.6 2.0 1 1 1 2 2 2 0 Dynamin-like helical domain Baculo_PEP_C PF04513.12 PIK46384.1 - 0.43 10.6 7.3 1.9 8.5 4.1 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 PIK46384.1 - 0.51 10.4 8.8 0.24 11.4 3.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1635 PF07795.11 PIK46384.1 - 0.53 10.1 11.1 0.64 9.9 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF4404 PF14357.6 PIK46384.1 - 0.54 10.9 14.4 1.2 9.8 0.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Phi-29_GP16_7 PF06720.11 PIK46384.1 - 0.58 10.0 5.7 0.94 9.3 5.7 1.5 1 1 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Fib_alpha PF08702.10 PIK46384.1 - 0.58 10.3 11.2 1.3 9.3 11.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 PIK46384.1 - 0.59 9.9 13.0 8.3 6.2 13.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FapA PF03961.13 PIK46384.1 - 0.61 8.6 7.2 0.72 8.4 7.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Golgin_A5 PF09787.9 PIK46384.1 - 0.61 9.5 18.6 1.3 8.4 18.6 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 5 TMF_DNA_bd PF12329.8 PIK46384.1 - 0.68 10.0 15.4 0.51 10.4 4.6 2.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 PIK46384.1 - 0.69 10.2 4.6 0.55 10.5 1.5 2.0 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.13 PIK46384.1 - 0.7 9.1 9.5 0.79 8.9 9.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4140 PF13600.6 PIK46384.1 - 0.72 10.3 11.4 2.9 8.4 2.5 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.19 PIK46384.1 - 0.89 7.4 11.3 1 7.2 11.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 PIK46384.1 - 1 9.9 19.6 58 4.2 7.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Bcr-Abl_Oligo PF09036.10 PIK46384.1 - 1.1 9.3 6.0 1.6 8.8 0.9 2.3 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Prominin PF05478.11 PIK46384.1 - 1.2 7.0 9.6 6.4 4.6 9.6 1.8 1 1 0 1 1 1 0 Prominin H-kinase_dim PF02895.14 PIK46384.1 - 1.7 9.1 8.6 0.25 11.8 1.6 2.2 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain DUF641 PF04859.12 PIK46384.1 - 1.9 8.9 11.4 0.38 11.1 2.4 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) LMBR1 PF04791.16 PIK46384.1 - 1.9 7.3 9.0 2.1 7.2 9.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 PIK46384.1 - 2.4 7.1 11.3 2.8 6.9 11.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 PIK46384.1 - 2.8 8.2 11.4 4.9 7.4 2.0 2.2 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II NPV_P10 PF05531.12 PIK46384.1 - 2.8 8.5 7.5 8.4 6.9 7.5 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 PIK46384.1 - 4.7 7.9 12.5 35 5.1 12.5 1.9 1 1 0 1 1 1 0 Initiation control protein YabA Spc24 PF08286.11 PIK46384.1 - 5.6 7.3 15.1 1.1 9.6 6.0 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Exonuc_VII_L PF02601.15 PIK46384.1 - 8.9 5.8 11.5 9.2 5.7 11.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ApoLp-III PF07464.11 PIK46385.1 - 0.00023 21.3 9.8 0.00023 21.3 9.8 2.2 1 1 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) RHH_8 PF17723.1 PIK46385.1 - 0.022 15.0 0.6 0.022 15.0 0.6 2.2 2 0 0 2 2 2 0 Ribbon-Helix-Helix transcriptional regulator family HMMR_N PF15905.5 PIK46385.1 - 0.061 12.8 37.9 0.67 9.4 11.2 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.11 PIK46385.1 - 0.17 10.7 39.4 0.21 10.4 39.4 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Baculo_PEP_C PF04513.12 PIK46385.1 - 0.47 10.5 5.6 2.9 7.9 0.1 3.0 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 PIK46385.1 - 1.2 9.6 7.4 16 6.1 1.6 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ApoO PF09769.9 PIK46385.1 - 1.7 8.6 8.6 0.7 9.9 0.2 3.0 1 1 2 3 3 3 0 Apolipoprotein O FAP206 PF12018.8 PIK46385.1 - 1.8 8.0 12.6 0.1 12.1 5.3 2.3 1 1 2 3 3 3 0 Domain of unknown function Lectin_N PF03954.14 PIK46385.1 - 2.2 8.0 14.5 1 9.1 2.9 2.8 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 PIK46385.1 - 2.7 8.0 20.9 1 9.4 6.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 PIK46385.1 - 4 7.5 36.1 3.5 7.7 17.9 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 PIK46385.1 - 5.7 6.7 11.4 1.1 9.1 2.7 2.8 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF948 PF06103.11 PIK46385.1 - 7.5 6.9 6.8 5.7 7.3 0.9 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Relaxase PF03432.14 PIK46385.1 - 8.5 5.9 22.7 0.049 13.2 7.7 2.0 1 1 1 2 2 2 0 Relaxase/Mobilisation nuclease domain Prominin PF05478.11 PIK46385.1 - 9.2 4.1 14.4 1.4 6.7 8.6 1.9 1 1 1 2 2 2 0 Prominin FokI_N PF02981.15 PIK46386.1 - 6.1 7.0 6.2 1 9.5 0.3 2.7 2 1 0 2 2 2 0 Restriction endonuclease FokI, recognition domain TAFII55_N PF04658.13 PIK46387.1 - 1.5e-12 47.5 0.9 1.5e-12 47.5 0.9 2.2 2 1 0 2 2 2 1 TAFII55 protein conserved region C2-set_2 PF08205.12 PIK46388.1 - 1.4e-06 28.3 1.6 0.0012 18.8 0.2 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK46388.1 - 8.7e-05 23.0 2.1 1 10.0 0.0 4.3 3 2 1 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK46388.1 - 9.8e-05 22.6 1.1 2.1 8.7 0.0 4.3 3 2 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK46388.1 - 0.01 16.0 0.0 0.74 10.0 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK46388.1 - 0.048 13.8 0.5 6.2 7.1 0.0 3.2 3 1 0 3 3 3 0 Immunoglobulin domain GOLD_2 PF13897.6 PIK46388.1 - 0.099 13.1 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Fibrinogen_C PF00147.18 PIK46389.1 - 4.2e-41 141.2 5.4 5.4e-41 140.8 5.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46389.1 - 7.4e-06 26.1 6.5 7.4e-06 26.1 6.5 3.1 2 1 0 2 2 2 1 EGF domain TIL PF01826.17 PIK46389.1 - 0.00022 21.4 26.1 0.0003 21.0 13.2 2.4 2 0 0 2 2 2 2 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.7 PIK46389.1 - 0.019 15.6 0.4 0.019 15.6 0.4 4.9 5 1 0 5 5 5 0 Human growth factor-like EGF cEGF PF12662.7 PIK46389.1 - 0.02 14.8 24.3 0.026 14.4 0.8 3.9 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF PF00008.27 PIK46389.1 - 3.7 7.9 28.4 1.3 9.4 4.6 3.7 2 1 0 2 2 2 0 EGF-like domain Fibrinogen_C PF00147.18 PIK46390.1 - 1.4e-46 159.1 14.7 6.5e-46 156.9 14.7 1.8 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK46391.1 - 2.7e-21 76.4 0.3 3.7e-21 76.0 0.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK46392.1 - 4.2e-60 203.3 18.3 3.7e-51 174.0 14.9 3.1 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46392.1 - 1.8e-05 24.8 10.8 2.6e-05 24.3 9.0 2.4 1 1 1 2 2 2 1 EGF domain COLFI PF01410.18 PIK46392.1 - 0.0004 19.8 3.6 0.00046 19.6 0.1 2.2 2 0 0 2 2 2 1 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK46392.1 - 0.00059 19.7 3.7 0.0019 18.1 3.7 1.9 1 0 0 1 1 1 1 TILa domain Fibrinogen_C PF00147.18 PIK46393.1 - 5.7e-42 144.0 1.9 8.4e-42 143.5 1.9 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46393.1 - 5.1e-07 29.8 5.5 5.1e-07 29.8 5.5 2.9 2 2 2 4 4 4 1 EGF domain COLFI PF01410.18 PIK46393.1 - 6.2e-05 22.4 0.9 7.9e-05 22.1 0.3 1.4 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK46393.1 - 0.00018 21.4 5.1 0.00018 21.4 5.1 2.2 1 1 1 2 2 2 1 TILa domain EB PF01683.18 PIK46393.1 - 0.33 11.3 14.0 6.3 7.2 14.0 2.3 1 1 0 1 1 1 0 EB module Fibrinogen_C PF00147.18 PIK46394.1 - 9e-48 163.0 17.5 3.8e-46 157.6 17.5 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain XendoU PF09412.10 PIK46395.1 - 8.5e-90 300.6 2.7 7.6e-89 297.4 2.7 1.9 1 1 0 1 1 1 1 Endoribonuclease XendoU Peptidase_M14 PF00246.24 PIK46396.1 - 1.4e-13 51.3 0.0 2.6e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 PIK46396.1 - 1.4e-09 38.3 0.0 5.4e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain zf-C2HC PF01530.18 PIK46396.1 - 0.019 15.1 0.5 0.056 13.7 0.0 2.0 2 0 0 2 2 2 0 Zinc finger, C2HC type AstE_AspA PF04952.14 PIK46396.1 - 0.12 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family TBP PF00352.21 PIK46398.1 - 1e-11 44.6 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor TFIID (or TATA-binding protein, TBP) Pkinase PF00069.25 PIK46399.1 - 6.7e-74 248.6 0.0 8.6e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46399.1 - 1.5e-35 122.8 0.1 2.6e-35 122.0 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Anoct_dimer PF16178.5 PIK46399.1 - 0.0014 18.4 0.5 0.0029 17.4 0.5 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Kinase-like PF14531.6 PIK46399.1 - 0.01 15.2 0.0 0.028 13.7 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 PIK46399.1 - 0.02 13.8 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain MBT PF02820.18 PIK46400.1 - 8.6e-87 285.5 4.5 4.1e-32 110.3 0.5 3.5 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.18 PIK46400.1 - 1.4e-27 95.6 25.2 2.8e-14 53.0 6.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2HC type SAM_1 PF00536.30 PIK46400.1 - 5.6e-13 49.1 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK46400.1 - 2.6e-05 24.2 0.0 5.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AIM5 PF17050.5 PIK46400.1 - 0.059 14.2 0.7 0.46 11.3 0.1 2.6 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 DUF5131 PF07505.11 PIK46400.1 - 0.074 12.5 0.8 10 5.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) Cas_Cas1 PF01867.16 PIK46400.1 - 0.16 11.1 0.2 0.25 10.4 0.2 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas1 AT_hook PF02178.19 PIK46400.1 - 2 8.5 11.6 10 6.4 2.6 3.0 2 0 0 2 2 2 0 AT hook motif RVT_1 PF00078.27 PIK46401.1 - 1.5e-20 73.7 0.0 1.7e-20 73.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-FCS PF06467.14 PIK46402.1 - 0.15 12.0 5.0 2.1 8.4 5.0 2.4 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif FAM198 PF15051.6 PIK46403.1 - 1.1e-22 80.3 0.5 1.2e-22 80.2 0.5 1.0 1 0 0 1 1 1 1 FAM198 protein Sec6 PF06046.13 PIK46405.1 - 2.9e-82 276.9 6.5 5.9e-82 275.9 6.5 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec6 SET PF00856.28 PIK46405.1 - 0.00095 19.6 0.1 0.00095 19.6 0.1 3.3 2 1 0 2 2 2 1 SET domain Exo84_C PF16528.5 PIK46405.1 - 0.032 14.1 1.7 0.081 12.7 0.1 2.6 2 0 0 2 2 2 0 Exocyst component 84 C-terminal Integrase_1 PF12835.7 PIK46405.1 - 0.23 11.5 2.0 0.81 9.8 0.1 2.5 2 0 0 2 2 2 0 Integrase Sushi PF00084.20 PIK46407.1 - 7.5e-18 64.9 30.3 2.3e-07 31.3 0.5 6.4 6 0 0 6 6 6 5 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK46408.1 - 0.00048 20.7 0.2 0.0049 17.4 0.1 2.4 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Ig_2 PF13895.6 PIK46408.1 - 0.0028 17.9 0.2 0.008 16.5 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK46408.1 - 0.0065 17.0 0.1 0.033 14.8 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set_CD47 PF08204.11 PIK46408.1 - 0.067 13.2 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain I-set PF07679.16 PIK46408.1 - 0.16 12.0 0.1 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain Sushi PF00084.20 PIK46409.1 - 4.5e-29 100.8 14.0 9.3e-10 39.0 1.1 3.2 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 PIK46409.1 - 0.73 10.2 11.5 3.4 8.0 0.8 3.8 2 1 1 3 3 3 0 Hormone receptor domain cEGF PF12662.7 PIK46409.1 - 3 7.9 11.9 0.79 9.7 0.6 3.4 4 0 0 4 4 4 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK46410.1 - 2.2e-12 47.4 10.1 6.1e-09 36.3 2.8 2.7 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) I-EGF_1 PF18372.1 PIK46410.1 - 0.34 11.0 4.9 1.6 8.9 0.1 3.1 3 0 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 Sushi PF00084.20 PIK46411.1 - 1.7e-16 60.6 19.0 5.5e-09 36.5 0.4 5.2 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK46412.1 - 5.8e-12 46.0 6.4 4.3e-10 40.0 1.2 2.7 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK46413.1 - 3.3e-28 98.0 14.4 3.6e-10 40.3 1.1 3.2 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 PIK46413.1 - 0.02 15.2 7.0 0.83 10.0 0.2 3.4 3 0 0 3 3 3 0 Hormone receptor domain cEGF PF12662.7 PIK46413.1 - 0.84 9.6 11.7 0.52 10.3 0.6 3.6 3 1 0 3 3 3 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK46414.1 - 9.4e-23 80.6 19.9 1.4e-08 35.2 1.8 5.6 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK46414.1 - 0.00054 20.5 0.5 0.0039 17.7 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK46414.1 - 0.0008 19.5 0.2 0.0038 17.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK46414.1 - 0.026 14.7 0.3 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK46414.1 - 0.081 13.3 0.0 0.081 13.3 0.0 3.1 4 0 0 4 4 4 0 Immunoglobulin domain HRM PF02793.22 PIK46414.1 - 0.7 10.2 8.6 2.8 8.3 0.3 3.2 3 0 0 3 3 3 0 Hormone receptor domain Patatin PF01734.22 PIK46415.1 - 8.5e-05 22.8 0.0 0.00013 22.3 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase DUF4487 PF14868.6 PIK46415.1 - 0.03 13.2 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) Ig_3 PF13927.6 PIK46416.1 - 0.00014 22.4 0.3 0.00028 21.4 0.3 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Sushi PF00084.20 PIK46416.1 - 0.00015 22.3 4.0 0.064 13.9 1.2 3.2 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) ig PF00047.25 PIK46416.1 - 0.00059 20.0 0.2 0.0012 18.9 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK46416.1 - 0.0018 18.6 0.1 0.0018 18.6 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK46416.1 - 0.17 12.1 0.1 0.17 12.1 0.1 1.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain Prok-RING_1 PF14446.6 PIK46417.1 - 0.0075 16.2 0.4 3.9 7.5 0.1 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 RVT_1 PF00078.27 PIK46418.1 - 2.1e-34 119.0 0.1 3.6e-34 118.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.29 PIK46418.1 - 1.2e-09 37.9 6.2 2.5e-09 36.9 6.2 1.6 1 0 0 1 1 1 1 PHD-finger Exo_endo_phos_2 PF14529.6 PIK46418.1 - 1.9e-08 34.1 0.5 6.3e-08 32.5 0.5 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK46418.1 - 0.0023 17.5 0.0 0.0055 16.3 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family C1_1 PF00130.22 PIK46418.1 - 0.0032 17.3 1.8 0.0032 17.3 1.8 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK46418.1 - 0.013 15.8 2.8 0.04 14.2 0.6 2.7 2 0 0 2 2 2 0 C1 domain zf-HC5HC2H PF13771.6 PIK46418.1 - 0.039 14.2 0.9 0.1 12.9 0.9 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RRPl_C4 PF17026.5 PIK46418.1 - 0.047 13.8 1.9 0.13 12.4 1.9 1.8 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type DNA_RNApol_7kD PF03604.13 PIK46418.1 - 0.26 11.0 2.6 0.84 9.4 2.6 1.9 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit PHD_2 PF13831.6 PIK46418.1 - 0.29 10.7 6.4 1.1 8.9 6.4 2.0 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 PIK46418.1 - 3.2 8.1 5.7 13 6.2 5.7 2.2 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 PIK46418.1 - 5.8 6.9 6.2 1.9 8.5 2.7 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 CUE PF02845.16 PIK46419.1 - 7.9e-06 25.5 0.0 3e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 CUE domain DUF4404 PF14357.6 PIK46419.1 - 0.052 14.2 0.1 0.23 12.1 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Ig_3 PF13927.6 PIK46421.1 - 5.6e-35 119.8 11.2 7.5e-12 45.7 0.1 5.5 6 0 0 6 6 6 4 Immunoglobulin domain I-set PF07679.16 PIK46421.1 - 7.7e-35 118.8 0.3 1.1e-14 54.2 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK46421.1 - 2.3e-24 85.5 6.9 1.4e-06 28.6 0.0 6.0 6 0 0 6 6 6 3 Immunoglobulin domain fn3 PF00041.21 PIK46421.1 - 4.8e-22 78.1 3.1 1.5e-12 47.7 1.4 3.1 3 0 0 3 3 2 2 Fibronectin type III domain ig PF00047.25 PIK46421.1 - 1.9e-20 72.8 4.2 1.7e-08 34.5 0.0 5.1 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 PIK46421.1 - 3.1e-12 46.6 0.8 0.023 14.9 0.0 5.3 4 1 1 5 5 5 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK46421.1 - 8.6e-06 25.2 0.0 0.6 9.7 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 PIK46421.1 - 0.00053 20.2 0.0 1.5 9.1 0.0 3.4 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK46421.1 - 0.00075 19.5 1.5 2.3 8.3 0.0 3.8 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK46421.1 - 0.0011 19.5 0.6 0.11 13.0 0.4 3.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 PIK46421.1 - 0.0029 17.4 0.5 0.31 10.9 0.4 2.6 1 1 1 2 2 2 1 Tissue factor 7TM_GPCR_Srz PF10325.9 PIK46421.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz 7tm_1 PF00001.21 PIK46422.1 - 5.3e-31 107.9 11.7 6.7e-31 107.6 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK46422.1 - 0.0082 15.6 19.5 0.51 9.7 11.7 2.9 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK46423.1 - 1.8e-34 119.3 2.8 2.4e-34 118.9 2.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46423.1 - 1.4e-13 51.1 6.3 1.7e-13 50.8 6.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK46423.1 - 0.00018 21.0 3.4 0.00025 20.5 3.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ISK_Channel PF02060.15 PIK46423.1 - 0.00095 18.9 0.2 0.37 10.5 0.1 2.3 2 0 0 2 2 2 2 Slow voltage-gated potassium channel 7TM_GPCR_Srv PF10323.9 PIK46423.1 - 0.0059 16.0 5.6 0.0052 16.2 4.9 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv FUSC-like PF12805.7 PIK46423.1 - 0.57 9.2 8.3 0.059 12.4 1.8 2.2 1 1 1 2 2 2 0 FUSC-like inner membrane protein yccS 7tm_1 PF00001.21 PIK46424.1 - 4.8e-34 117.9 2.8 6.5e-34 117.5 2.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK46424.1 - 6.9e-13 48.8 8.1 9.1e-13 48.4 8.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK46424.1 - 0.00053 19.4 3.6 0.00076 18.9 3.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ISK_Channel PF02060.15 PIK46424.1 - 0.0034 17.1 0.2 1.2 8.8 0.1 2.3 2 0 0 2 2 2 2 Slow voltage-gated potassium channel Mre11_DNA_bind PF04152.14 PIK46425.1 - 2.2e-16 60.7 0.3 3.9e-16 59.8 0.3 1.4 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 PIK46425.1 - 6.7e-16 59.4 0.2 1.6e-15 58.2 0.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK46425.1 - 2.8e-06 27.6 0.0 2.3e-05 24.6 0.0 2.5 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain TBSV_P22 PF03558.13 PIK46425.1 - 0.029 13.8 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 TBSV core protein P21/P22 Autophagy_act_C PF03987.15 PIK46425.1 - 0.041 14.5 0.0 6.7 7.4 0.0 2.9 2 1 0 2 2 2 0 Autophagocytosis associated protein, active-site domain DCP2 PF05026.13 PIK46425.1 - 0.056 13.8 0.0 0.99 9.8 0.0 2.6 2 0 0 2 2 2 0 Dcp2, box A domain Mre11_DNA_bind PF04152.14 PIK46426.1 - 6.9e-38 130.6 0.0 1e-37 130.0 0.0 1.3 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 PIK46426.1 - 3.5e-06 27.7 0.2 1e-05 26.1 0.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Inhibitor_I53 PF11714.8 PIK46427.1 - 0.13 12.5 1.4 0.31 11.3 0.7 1.9 2 0 0 2 2 2 0 Thrombin inhibitor Madanin FAM76 PF16046.5 PIK46428.1 - 0.49 9.7 17.2 0.71 9.2 17.2 1.2 1 0 0 1 1 1 0 FAM76 protein Hid1 PF12722.7 PIK46428.1 - 0.78 7.8 16.4 0.73 7.9 16.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RVT_1 PF00078.27 PIK46429.1 - 2.4e-32 112.2 0.2 4.1e-32 111.5 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DED PF01335.21 PIK46430.1 - 4.4e-05 23.7 0.0 0.1 12.9 0.0 2.3 2 0 0 2 2 2 2 Death effector domain ZU5 PF00791.20 PIK46431.1 - 1.2e-13 51.3 0.0 3.5e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain RVT_1 PF00078.27 PIK46434.1 - 4.8e-16 58.9 0.0 6.5e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK46435.1 - 4e-11 42.8 0.0 6e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tnp_P_element PF12017.8 PIK46436.1 - 7.4e-07 28.8 0.3 6.4e-06 25.8 0.2 2.3 1 1 0 1 1 1 1 Transposase protein FtsA PF14450.6 PIK46437.1 - 0.13 12.7 0.6 0.42 11.1 0.1 1.9 1 1 1 2 2 2 0 Cell division protein FtsA LMBR1 PF04791.16 PIK46437.1 - 0.16 10.8 2.5 0.17 10.7 2.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C2H2_10 PF16588.5 PIK46439.1 - 0.0027 17.4 0.6 0.0076 15.9 0.6 1.8 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 PIK46439.1 - 0.0038 17.2 10.0 0.055 13.6 0.5 3.2 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK46439.1 - 0.036 13.8 4.8 2 8.2 0.4 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46439.1 - 0.037 14.0 1.0 0.037 14.0 1.0 2.8 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46439.1 - 0.74 9.7 10.3 0.21 11.4 6.2 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 PIK46441.1 - 5.1e-07 29.5 15.8 0.00065 19.7 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46441.1 - 0.00053 19.8 7.8 0.1 12.5 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46441.1 - 0.022 14.6 0.2 0.022 14.6 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK46441.1 - 0.022 14.5 0.8 0.022 14.5 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK46441.1 - 0.037 13.8 11.1 4.9 7.0 0.3 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46441.1 - 0.058 13.4 16.5 0.25 11.4 1.2 3.7 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC PF00098.23 PIK46442.1 - 7.1e-08 32.2 15.1 0.00041 20.3 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46442.1 - 0.0002 21.1 7.7 0.061 13.2 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46442.1 - 0.0012 18.7 12.6 0.16 12.0 1.3 3.4 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK46442.1 - 0.0091 15.7 11.1 3.1 7.6 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46442.1 - 0.014 15.2 0.2 0.014 15.2 0.2 3.4 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK46442.1 - 0.014 15.1 0.8 0.014 15.1 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC PF00098.23 PIK46444.1 - 1.5e-07 31.2 18.9 0.00029 20.8 0.2 4.6 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46444.1 - 0.00012 21.9 8.1 0.042 13.7 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK46444.1 - 0.0031 17.2 11.3 2.2 8.1 0.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46444.1 - 0.0065 16.4 17.4 0.15 12.1 1.6 3.9 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46444.1 - 0.0098 15.7 0.2 0.0098 15.7 0.2 4.0 4 0 0 4 4 4 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK46444.1 - 0.0099 15.6 0.8 0.0099 15.6 0.8 2.8 1 1 1 2 2 2 1 C2H2 zinc-finger Integrase_H2C2 PF17921.1 PIK46445.1 - 3.5e-17 62.2 0.1 9.1e-17 60.9 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46445.1 - 0.00012 21.8 0.1 0.00051 19.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain UCH PF00443.29 PIK46445.1 - 0.00013 21.5 7.4 0.003 17.1 0.4 3.3 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-H2C2 PF09337.10 PIK46445.1 - 0.00018 21.6 0.0 0.00053 20.1 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 PIK46445.1 - 0.0014 18.8 0.0 0.0027 17.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain CutA1 PF03091.15 PIK46445.1 - 0.0015 18.4 0.1 0.0053 16.6 0.1 1.9 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein UCH PF00443.29 PIK46446.1 - 5.5e-12 45.7 0.1 6.9e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK46446.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase NDK PF00334.19 PIK46447.1 - 0.047 13.7 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Nucleoside diphosphate kinase ATHILA PF03078.15 PIK46448.1 - 0.033 13.0 2.2 0.05 12.4 2.2 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family zf-Di19 PF05605.12 PIK46448.1 - 1.3 9.4 4.2 24 5.3 0.4 2.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding tRNA_anti-codon PF01336.25 PIK46449.1 - 0.0015 18.5 2.6 0.0068 16.4 0.1 3.0 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 PIK46449.1 - 0.032 13.9 1.8 0.74 9.5 0.0 2.6 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 UvrD_C_2 PF13538.6 PIK46449.1 - 0.081 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain zf-CCHC_5 PF14787.6 PIK46452.1 - 0.25 11.1 8.6 0.88 9.3 0.2 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 PIK46452.1 - 1.2 8.9 14.2 1.4 8.7 0.5 3.6 2 1 1 3 3 3 0 Zinc knuckle IBR PF01485.21 PIK46452.1 - 1.7 8.9 13.0 0.77 10.0 7.6 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-CCHC PF00098.23 PIK46452.1 - 7.1 6.9 11.5 4.4 7.5 2.6 3.4 3 0 0 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK46453.1 - 1.3e-23 83.7 0.0 3.6e-17 62.6 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK46454.1 - 2.6e-34 118.7 0.0 3.3e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HBM PF16591.5 PIK46457.1 - 0.046 13.1 0.1 0.05 13.0 0.1 1.1 1 0 0 1 1 1 0 Helical bimodular sensor domain DUF2175 PF09943.9 PIK46457.1 - 0.12 12.7 0.3 0.15 12.3 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Fea1 PF07692.11 PIK46458.1 - 0.026 13.6 0.1 0.039 13.0 0.1 1.2 1 0 0 1 1 1 0 Low iron-inducible periplasmic protein Promethin PF16015.5 PIK46458.1 - 0.063 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Promethin PspB PF06667.12 PIK46458.1 - 0.079 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Phage shock protein B Ig_3 PF13927.6 PIK46459.1 - 0.0001 22.8 5.3 0.49 11.0 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK46459.1 - 0.00016 21.6 0.9 0.008 16.2 0.1 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK46459.1 - 0.003 17.7 1.9 2.8 8.2 0.0 3.7 3 1 1 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK46459.1 - 0.028 14.5 0.4 6 7.0 0.0 3.5 3 1 0 3 3 3 0 Immunoglobulin I-set domain DUF2204 PF09970.9 PIK46459.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) RVT_1 PF00078.27 PIK46460.1 - 7.4e-05 22.4 0.1 9.3e-05 22.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAS_3 PF08447.12 PIK46460.1 - 0.13 12.6 0.0 0.36 11.1 0.0 1.7 2 0 0 2 2 2 0 PAS fold RVT_1 PF00078.27 PIK46461.1 - 1.1e-11 44.7 0.0 2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HxlR PF01638.17 PIK46461.1 - 0.019 14.8 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 HxlR-like helix-turn-helix NRD1_2 PF01995.16 PIK46461.1 - 0.17 11.1 0.0 0.73 9.1 0.0 1.8 2 0 0 2 2 2 0 NrpR regulatory domains NRD1 and 2 ig PF00047.25 PIK46462.1 - 0.00037 20.6 6.4 0.015 15.5 0.5 3.4 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK46462.1 - 0.0024 17.9 2.4 0.12 12.5 0.3 3.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK46462.1 - 0.0062 17.1 11.8 0.099 13.3 1.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain Ig_5 PF16681.5 PIK46462.1 - 0.017 15.5 0.1 0.26 11.7 0.0 2.5 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 PIK46462.1 - 0.038 14.3 8.1 0.075 13.4 0.4 3.9 3 1 0 4 4 4 0 Immunoglobulin domain JAKMIP_CC3 PF16034.5 PIK46462.1 - 0.067 13.1 0.3 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 JAKMIP CC3 domain DUF2840 PF11000.8 PIK46462.1 - 0.085 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) TssO PF17561.2 PIK46463.1 - 0.028 14.5 1.3 0.054 13.6 1.3 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssO Sarcoglycan_2 PF05510.13 PIK46463.1 - 0.1 11.3 0.1 0.16 10.7 0.1 1.2 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Sigma_reg_N PF13800.6 PIK46463.1 - 0.14 12.4 2.6 0.68 10.3 2.5 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Tir_receptor_M PF03549.14 PIK46463.1 - 0.21 11.9 1.1 5.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) intimin-binding domain DUF5641 PF18701.1 PIK46464.1 - 1.9e-31 108.1 2.9 1.9e-31 108.1 2.9 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5641) Peptidase_A17 PF05380.13 PIK46464.1 - 3.9e-26 92.0 0.0 9.9e-26 90.7 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK46464.1 - 1.5e-08 34.6 0.7 5.4e-08 32.8 0.1 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK46464.1 - 2.3e-08 34.2 0.0 5.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain TssO PF17561.2 PIK46465.1 - 0.011 15.8 1.8 0.02 15.0 1.8 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO ig PF00047.25 PIK46465.1 - 0.086 13.0 0.7 0.59 10.3 0.4 2.4 2 0 0 2 2 2 0 Immunoglobulin domain TMEM154 PF15102.6 PIK46465.1 - 0.092 12.7 1.0 0.16 11.9 0.2 1.8 2 0 0 2 2 2 0 TMEM154 protein family Sigma_reg_N PF13800.6 PIK46465.1 - 0.19 12.1 3.3 0.69 10.2 2.4 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Ig_3 PF13927.6 PIK46466.1 - 0.00027 21.5 8.0 0.36 11.5 0.7 3.8 2 2 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK46466.1 - 0.00088 19.4 5.6 0.33 11.2 0.6 4.0 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK46466.1 - 0.0026 18.0 10.3 0.13 12.7 1.2 4.1 3 1 1 4 4 4 2 Immunoglobulin domain Protocadherin PF08374.11 PIK46466.1 - 0.013 15.5 0.3 0.034 14.1 0.0 1.9 2 0 0 2 2 2 0 Protocadherin V-set PF07686.17 PIK46466.1 - 0.024 14.8 0.1 1.3 9.2 0.1 2.9 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK46466.1 - 0.024 15.0 1.1 0.86 10.1 0.0 3.7 4 0 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK46466.1 - 0.082 13.0 0.1 2.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Immunoglobulin I-set domain DUF2204 PF09970.9 PIK46467.1 - 0.00052 19.7 0.1 0.00086 19.0 0.1 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF2204) SRP-alpha_N PF04086.13 PIK46468.1 - 6.2 6.6 44.5 7.5 6.4 44.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal tRNA-synt_2c PF01411.19 PIK46469.1 - 2.2e-176 587.7 0.0 2.4e-174 580.9 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 PIK46469.1 - 4.4e-08 33.1 0.2 1.2e-07 31.7 0.2 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 PIK46469.1 - 0.00069 20.1 0.0 0.0014 19.1 0.0 1.6 1 0 0 1 1 1 1 DHHA1 domain DUF2682 PF10909.8 PIK46469.1 - 0.16 12.5 0.6 0.36 11.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) bZIP_2 PF07716.15 PIK46472.1 - 1.4e-08 34.7 17.3 3.7e-08 33.3 17.3 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK46472.1 - 2.2e-05 24.5 18.8 5.5e-05 23.2 18.8 1.6 1 0 0 1 1 1 1 bZIP transcription factor TMCO5 PF14992.6 PIK46472.1 - 0.033 13.8 9.3 0.052 13.1 9.3 1.2 1 0 0 1 1 1 0 TMCO5 family FlaC_arch PF05377.11 PIK46472.1 - 0.059 13.8 3.6 0.4 11.1 2.9 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) L31 PF09784.9 PIK46472.1 - 0.15 12.5 8.1 0.078 13.4 3.6 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 Ax_dynein_light PF10211.9 PIK46472.1 - 0.23 11.4 9.2 0.42 10.5 9.2 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain Bcr-Abl_Oligo PF09036.10 PIK46472.1 - 0.32 11.0 3.2 0.75 9.8 3.2 1.7 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain YabA PF06156.13 PIK46472.1 - 1 10.1 7.1 2.9 8.6 7.1 1.8 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 PIK46472.1 - 1.4 8.8 7.2 2.3 8.0 6.4 1.8 1 1 0 1 1 1 0 Septum formation initiator Tho2 PF11262.8 PIK46472.1 - 2 7.6 9.8 2.9 7.0 9.8 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4407 PF14362.6 PIK46472.1 - 3.3 7.0 6.2 5.4 6.3 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4094 PF13334.6 PIK46472.1 - 5.2 7.6 8.1 7.6 7.0 6.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) FA_hydroxylase PF04116.13 PIK46473.1 - 1.8e-26 93.0 11.0 1.8e-26 93.0 11.0 2.5 3 1 0 3 3 3 1 Fatty acid hydroxylase superfamily Na_Pi_cotrans PF02690.15 PIK46474.1 - 1.5e-40 138.5 23.6 9.4e-27 93.8 6.3 2.6 2 1 0 2 2 2 2 Na+/Pi-cotransporter Ion_trans PF00520.31 PIK46475.1 - 1.3e-16 60.5 18.2 2.2e-16 59.8 18.2 1.2 1 0 0 1 1 1 1 Ion transport protein LSDAT_euk PF18139.1 PIK46476.1 - 6.6e-48 163.4 0.0 8.8e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 PIK46476.1 - 5.9e-17 61.6 0.0 2.5e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 SLOG in TRPM, prokaryote Peptidase_C1 PF00112.23 PIK46477.1 - 4.1e-82 275.5 4.5 6.7e-82 274.8 4.5 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK46477.1 - 4.9e-13 49.3 0.0 9.4e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK46477.1 - 2e-05 23.5 2.0 0.026 13.3 0.7 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 PIK46478.1 - 2e-07 31.3 0.1 2.7e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF3685 PF12452.8 PIK46478.1 - 0.073 12.8 0.5 0.087 12.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) COesterase PF00135.28 PIK46479.1 - 1.7e-135 452.8 0.0 2e-135 452.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK46479.1 - 3.1e-12 46.8 0.1 1.4e-11 44.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK46479.1 - 0.0041 16.6 0.8 0.011 15.3 0.8 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family AChE_tetra PF08674.10 PIK46479.1 - 4.9 6.9 15.8 0.046 13.4 3.7 3.2 3 0 0 3 3 3 0 Acetylcholinesterase tetramerisation domain Cation_efflux PF01545.21 PIK46480.1 - 4.6e-47 160.3 20.0 5.6e-47 160.1 20.0 1.1 1 0 0 1 1 1 1 Cation efflux family DUF3343 PF11823.8 PIK46480.1 - 0.095 12.2 0.3 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) HECT PF00632.25 PIK46481.1 - 2.8e-58 197.8 0.0 3.7e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RVT_1 PF00078.27 PIK46482.1 - 3e-10 40.0 0.0 4.5e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5362 PF17319.2 PIK46482.1 - 0.17 11.7 0.0 4.9 7.1 0.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5362) Tnp_P_element PF12017.8 PIK46483.1 - 2e-14 53.6 2.1 4.4e-14 52.4 2.1 1.6 1 1 0 1 1 1 1 Transposase protein TcA_TcB_BD PF18276.1 PIK46483.1 - 0.02 14.0 0.2 0.032 13.3 0.2 1.3 1 0 0 1 1 1 0 Tc toxin complex TcA C-terminal TcB-binding domain KLRAQ PF10205.9 PIK46483.1 - 0.72 10.1 5.3 0.31 11.3 1.3 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Rx_N PF18052.1 PIK46483.1 - 4.8 7.5 8.6 1.9 8.8 2.4 2.6 2 1 0 2 2 2 0 Rx N-terminal domain RT_RNaseH PF17917.1 PIK46484.1 - 1.4e-30 105.7 0.1 2.3e-30 105.0 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46484.1 - 2.1e-25 88.7 0.1 3.8e-25 87.8 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46484.1 - 1.1e-08 34.9 0.0 1.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TrmB PF01978.19 PIK46485.1 - 0.016 15.1 0.0 0.099 12.5 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB PqqD PF05402.12 PIK46485.1 - 0.16 12.3 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) DnaJ PF00226.31 PIK46486.1 - 5.6e-22 77.6 0.9 1.3e-21 76.4 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain Sec61_beta PF03911.16 PIK46486.1 - 0.04 14.0 0.3 0.076 13.1 0.3 1.4 1 0 0 1 1 1 0 Sec61beta family polyprenyl_synt PF00348.17 PIK46487.1 - 6.9e-90 300.6 0.2 9.6e-90 300.1 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase BRICHOS PF04089.14 PIK46488.1 - 1.9e-08 34.4 0.0 4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain THAP PF05485.12 PIK46489.1 - 5.8e-15 56.0 4.9 4.4e-14 53.2 2.2 2.6 2 0 0 2 2 2 1 THAP domain Trans_coact PF16805.5 PIK46489.1 - 0.26 11.4 2.7 1.4 9.1 0.6 2.4 2 0 0 2 2 2 0 Phage late-transcription coactivator MFS_1 PF07690.16 PIK46490.1 - 7.2e-16 58.0 42.8 2.5e-09 36.5 26.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipase_GDSL_2 PF13472.6 PIK46491.1 - 0.17 12.3 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pkinase PF00069.25 PIK46492.1 - 8.8e-45 153.1 0.0 1.4e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46492.1 - 3.6e-30 105.1 0.1 7.6e-30 104.0 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK46492.1 - 4.7e-06 25.6 3.4 1.6e-05 23.9 0.0 2.6 2 1 1 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 PIK46492.1 - 0.00014 21.3 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 PIK46492.1 - 0.015 15.2 0.0 0.048 13.6 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 PIK46492.1 - 0.053 12.6 0.1 0.093 11.8 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 SH3_1 PF00018.28 PIK46493.1 - 2.8e-08 33.2 0.1 4.6e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK46493.1 - 0.0038 16.9 0.0 0.0046 16.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK46493.1 - 0.015 15.2 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain tRNA-synt_2 PF00152.20 PIK46494.1 - 2.4e-09 36.7 0.0 3.1e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 PIK46495.1 - 1.9e-07 30.9 0.0 4.6e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain TIR_2 PF13676.6 PIK46496.1 - 5e-14 52.9 0.0 9.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 PIK46496.1 - 4.8e-05 23.2 0.3 0.00015 21.6 0.1 1.9 2 0 0 2 2 2 1 TIR domain DED PF01335.21 PIK46496.1 - 0.006 16.9 0.1 0.017 15.4 0.1 1.9 1 0 0 1 1 1 1 Death effector domain DUF3052 PF11253.8 PIK46496.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Actin PF00022.19 PIK46497.1 - 2.4e-43 148.3 0.0 4.9e-42 144.0 0.0 2.1 1 1 0 1 1 1 1 Actin BORCS6 PF10157.9 PIK46497.1 - 0.026 14.7 1.4 0.032 14.5 0.0 1.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 PRK PF00485.18 PIK46498.1 - 1.5e-32 112.9 1.0 1.5e-32 112.9 1.0 2.2 2 1 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Pkinase PF00069.25 PIK46499.1 - 1.1e-72 244.6 0.0 1.4e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46499.1 - 9.3e-34 116.9 0.0 1.2e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK46499.1 - 1.7e-07 30.5 0.0 2.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK46499.1 - 3.8e-07 29.7 0.2 5.3e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 PIK46499.1 - 0.013 15.1 0.3 0.048 13.2 0.3 1.8 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 PIK46499.1 - 0.014 15.3 0.0 0.81 9.6 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK46499.1 - 0.015 14.1 0.0 0.03 13.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Taeniidae_ag PF05596.11 PIK46499.1 - 1.2 9.2 3.7 14 5.7 0.2 3.4 4 0 0 4 4 4 0 Taeniidae antigen DED PF01335.21 PIK46500.1 - 0.00037 20.7 0.3 0.0005 20.3 0.3 1.1 1 0 0 1 1 1 1 Death effector domain CARD PF00619.21 PIK46500.1 - 0.11 12.5 0.3 0.16 12.0 0.3 1.2 1 0 0 1 1 1 0 Caspase recruitment domain Peptidase_C14 PF00656.22 PIK46501.1 - 7.1e-25 88.4 0.0 1.2e-24 87.7 0.0 1.3 1 0 0 1 1 1 1 Caspase domain VCX_VCY PF15231.6 PIK46501.1 - 0.003 18.3 0.1 16 6.2 0.0 3.4 1 1 2 3 3 3 3 Variable charge X/Y family TFIIB PF00382.19 PIK46502.1 - 6.7e-50 167.0 2.2 7.3e-24 83.6 0.3 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 PIK46502.1 - 3.6e-12 45.6 0.4 6.9e-12 44.7 0.4 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 PIK46502.1 - 2.8e-07 30.3 0.1 1.7e-05 24.5 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK46502.1 - 0.00032 20.8 0.0 0.061 13.4 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.20 PIK46502.1 - 0.009 16.0 0.1 0.025 14.6 0.1 1.8 1 1 0 1 1 1 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.16 PIK46502.1 - 0.022 14.3 0.0 0.31 10.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 TFIIB_C_1 PF18542.1 PIK46502.1 - 0.054 13.5 0.5 1.3 9.0 0.1 2.4 2 1 0 2 2 2 0 Transcription factor IIB C-terminal module 1 DUF2039 PF10217.9 PIK46502.1 - 3.1 8.2 8.4 0.41 11.0 2.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Snapin_Pallidin PF14712.6 PIK46503.1 - 1.2e-22 80.1 1.4 1.6e-22 79.8 1.4 1.1 1 0 0 1 1 1 1 Snapin/Pallidin Spc7 PF08317.11 PIK46503.1 - 0.0039 16.1 3.1 0.0049 15.8 3.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Gag_p15 PF08723.10 PIK46503.1 - 0.0047 17.1 0.1 0.0058 16.8 0.1 1.1 1 0 0 1 1 1 1 Gag protein p15 Eisosome1 PF12757.7 PIK46503.1 - 0.021 15.1 2.6 0.071 13.4 0.3 2.1 2 0 0 2 2 2 0 Eisosome protein 1 PspA_IM30 PF04012.12 PIK46503.1 - 0.12 12.0 5.8 1.7 8.2 0.6 2.0 1 1 1 2 2 2 0 PspA/IM30 family DUF1664 PF07889.12 PIK46503.1 - 0.12 12.4 2.2 0.16 12.0 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 PIK46503.1 - 0.12 12.4 3.9 2.1 8.4 0.5 2.1 1 1 1 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 PIK46503.1 - 0.26 11.6 3.6 0.28 11.5 1.5 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FYVE_2 PF02318.16 PIK46503.1 - 0.27 11.5 1.6 0.35 11.1 0.1 1.8 1 1 1 2 2 2 0 FYVE-type zinc finger DivIC PF04977.15 PIK46503.1 - 0.79 9.5 5.8 1.6 8.5 2.2 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF16 PF01519.16 PIK46503.1 - 1.2 9.7 5.4 1.1 9.7 3.1 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 EURL PF06937.11 PIK46503.1 - 1.9 7.8 6.2 10 5.4 2.0 2.0 1 1 1 2 2 2 0 EURL protein Ham1p_like PF01725.16 PIK46504.1 - 1.9e-54 184.4 0.0 2.6e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 Ham1 family FA_desaturase PF00487.24 PIK46505.1 - 0.0023 17.8 3.1 0.0032 17.3 3.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF1211 PF06736.11 PIK46505.1 - 0.076 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) FA_desaturase PF00487.24 PIK46506.1 - 2.6e-18 66.8 18.6 3.4e-18 66.4 18.6 1.1 1 0 0 1 1 1 1 Fatty acid desaturase TDP43_N PF18694.1 PIK46506.1 - 0.049 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Transactive response DNA-binding protein N-terminal domain RVT_1 PF00078.27 PIK46507.1 - 3.7e-29 101.8 0.4 8.5e-29 100.6 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RIC3 PF15361.6 PIK46507.1 - 0.1 13.0 0.4 0.19 12.1 0.0 1.6 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 FA_desaturase PF00487.24 PIK46508.1 - 3.6e-05 23.7 4.1 4.5e-05 23.4 4.1 1.1 1 0 0 1 1 1 1 Fatty acid desaturase FA_desaturase PF00487.24 PIK46509.1 - 0.037 13.9 0.5 0.038 13.8 0.5 1.2 1 0 0 1 1 1 0 Fatty acid desaturase FA_desaturase PF00487.24 PIK46510.1 - 5.1e-11 42.9 12.1 5.1e-11 42.9 12.1 1.4 2 0 0 2 2 2 1 Fatty acid desaturase PBP1_TM PF14812.6 PIK46512.1 - 0.00064 20.0 3.3 0.001 19.4 3.3 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.12 PIK46512.1 - 0.35 9.0 2.3 0.41 8.8 2.3 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK46512.1 - 0.57 9.6 4.7 0.69 9.3 4.7 1.0 1 0 0 1 1 1 0 SDA1 RXT2_N PF08595.11 PIK46512.1 - 0.67 10.0 2.9 0.93 9.5 2.9 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 PIK46512.1 - 1.5 8.5 7.5 2.1 8.0 7.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 PIK46512.1 - 8.2 5.6 13.2 5.7 6.2 10.8 1.7 2 0 0 2 2 2 0 NOA36 protein EST1_DNA_bind PF10373.9 PIK46513.1 - 1.7e-09 37.6 1.2 2.1e-09 37.3 0.3 1.5 1 1 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 PIK46514.1 - 1.3e-20 74.4 0.3 2.9e-20 73.3 0.3 1.6 1 0 0 1 1 1 1 Telomerase activating protein Est1 EST1_DNA_bind PF10373.9 PIK46514.1 - 4.6e-12 46.0 5.3 5.2e-12 45.8 1.2 2.1 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain FliT PF05400.13 PIK46514.1 - 0.18 12.6 1.7 0.62 10.9 0.2 2.1 2 0 0 2 2 2 0 Flagellar protein FliT FAM199X PF15814.5 PIK46515.1 - 4.9e-06 25.8 4.7 1.2e-05 24.5 4.7 1.7 1 1 0 1 1 1 1 Protein family FAM199X MRP-S25 PF13741.6 PIK46515.1 - 6.2 6.3 8.6 4.2 6.9 0.2 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal protein S25 CD225 PF04505.12 PIK46516.1 - 1.2e-24 86.3 2.3 1.2e-24 86.3 2.3 1.8 1 1 1 2 2 2 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 PIK46516.1 - 0.032 14.0 0.3 0.032 14.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) DUF2852 PF11014.8 PIK46516.1 - 0.1 12.8 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) RVT_1 PF00078.27 PIK46517.1 - 1.6e-44 152.1 0.2 2.4e-44 151.5 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CD225 PF04505.12 PIK46518.1 - 1.6e-18 66.5 1.8 2.4e-18 66.0 1.8 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF3153 PF11353.8 PIK46518.1 - 0.078 12.5 0.5 0.12 11.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) Lectin_N PF03954.14 PIK46518.1 - 0.17 11.7 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain UL45 PF05473.12 PIK46518.1 - 0.39 10.3 5.2 36 3.9 5.2 2.1 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like MttA_Hcf106 PF02416.16 PIK46518.1 - 1.1 8.6 2.6 2 7.8 2.6 1.4 1 0 0 1 1 1 0 mttA/Hcf106 family BRICHOS PF04089.14 PIK46519.1 - 4.4e-13 49.3 0.2 1.1e-12 48.0 0.2 1.6 1 0 0 1 1 1 1 BRICHOS domain Zip PF02535.22 PIK46520.1 - 0.0048 16.2 0.2 0.0053 16.0 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter OAD_gamma PF04277.13 PIK46520.1 - 0.089 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Nop14 PF04147.12 PIK46520.1 - 0.41 8.8 8.3 0.46 8.6 8.3 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 PIK46520.1 - 1.1 7.4 12.4 1.3 7.2 12.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 PIK46521.1 - 0.13 10.4 6.4 0.14 10.3 6.4 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 PIK46521.1 - 0.43 8.8 11.2 0.55 8.5 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 PIK46521.1 - 6.9 6.7 10.9 12 5.9 10.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein GTP-bdg_M PF16360.5 PIK46523.1 - 1.7e-18 67.0 5.9 3.6e-18 65.9 5.9 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 PIK46523.1 - 1e-14 54.6 0.1 2.6e-14 53.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.6 PIK46523.1 - 4e-14 53.0 0.0 8.9e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal cobW PF02492.19 PIK46523.1 - 0.00022 20.9 0.7 0.13 11.8 0.0 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 PIK46523.1 - 0.012 15.1 0.1 0.031 13.8 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK46523.1 - 0.022 14.8 0.1 0.72 9.9 0.0 2.3 1 1 1 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 PIK46523.1 - 0.033 14.1 0.1 0.52 10.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 PIK46524.1 - 2.2e-40 138.3 0.0 5.1e-40 137.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK46524.1 - 3.7e-22 78.7 0.0 1.6e-20 73.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK46524.1 - 3.7e-07 30.3 3.1 1.5e-06 28.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 PIK46524.1 - 0.00041 20.2 0.3 0.025 14.4 0.0 2.5 2 0 0 2 2 2 1 Helicase Helicase_C_2 PF13307.6 PIK46524.1 - 0.36 11.0 3.0 6.3 6.9 0.0 3.0 3 0 0 3 3 3 0 Helicase C-terminal domain WD40 PF00400.32 PIK46525.1 - 2.7e-27 94.5 9.7 0.00039 21.2 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.11 PIK46525.1 - 0.00081 19.3 0.0 0.45 10.4 0.0 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 PIK46525.1 - 0.0021 18.3 0.3 3.5 8.0 0.0 3.8 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK46525.1 - 0.0062 15.2 10.1 2.8 6.5 0.1 4.2 3 2 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK46525.1 - 0.043 13.1 0.0 7.6 5.8 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain RVT_1 PF00078.27 PIK46526.1 - 1.8e-34 119.2 0.5 2.7e-34 118.6 0.5 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK46527.1 - 6.7e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF812 PF05667.11 PIK46527.1 - 2.1 7.1 66.1 0.29 9.9 1.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF812) EKAL PF17986.1 PIK46527.1 - 6.2 6.9 6.9 1.8 8.7 1.5 2.6 2 0 0 2 2 2 0 EMP3-KAHRP-like N-terminal domain C2 PF00168.30 PIK46528.1 - 1.9e-31 108.4 0.9 1.3e-15 57.6 0.1 3.0 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.19 PIK46528.1 - 7.7e-24 84.6 0.4 5.6e-13 49.1 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase BTK PF00779.19 PIK46528.1 - 4e-11 42.5 1.2 7.1e-11 41.7 1.2 1.4 1 0 0 1 1 1 1 BTK motif PH PF00169.29 PIK46528.1 - 1.8e-08 34.8 3.7 3.1e-08 34.1 0.5 2.5 2 0 0 2 2 2 1 PH domain Bromodomain PF00439.25 PIK46529.1 - 6e-21 74.3 0.4 5.4e-20 71.3 0.0 2.2 2 0 0 2 2 2 1 Bromodomain Ribos_L4_asso_C PF14374.6 PIK46529.1 - 0.076 13.1 1.6 14 5.8 0.6 3.0 1 1 2 3 3 3 0 60S ribosomal protein L4 C-terminal domain ENT PF03735.14 PIK46530.1 - 1.8e-22 79.1 0.2 3.2e-22 78.4 0.2 1.4 1 0 0 1 1 1 1 ENT domain DUF4707 PF15806.5 PIK46531.1 - 7.8e-12 44.9 4.2 1.1e-11 44.3 4.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4707) CTX_RstB PF07459.11 PIK46531.1 - 0.085 13.1 1.5 0.99 9.7 0.0 2.2 2 0 0 2 2 2 0 CTX phage RstB protein KIAA1430 PF13879.6 PIK46532.1 - 1.2e-26 93.4 8.6 1.2e-26 93.4 8.6 2.6 2 1 0 2 2 2 1 KIAA1430 homologue FancD2 PF14631.6 PIK46532.1 - 0.93 6.8 12.8 1.3 6.3 12.8 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RB_A PF01858.17 PIK46533.1 - 1.2e-55 188.5 1.7 1.2e-55 188.4 0.3 1.8 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 PIK46533.1 - 1.1e-30 106.3 1.7 2.2e-30 105.4 0.0 2.4 3 0 0 3 3 3 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 PIK46533.1 - 5.3e-10 39.0 0.5 2.3e-07 30.5 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3452) TFIIB PF00382.19 PIK46533.1 - 0.035 14.2 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Transcription factor TFIIB repeat F1F0-ATPsyn_F PF10791.9 PIK46533.1 - 0.058 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi fn3 PF00041.21 PIK46534.1 - 8e-25 87.0 5.7 4.7e-09 36.5 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK46534.1 - 0.0021 18.6 0.3 0.27 11.8 0.0 3.6 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain Cullin PF00888.22 PIK46535.1 - 6.8e-205 682.3 18.7 8.3e-205 682.0 18.7 1.1 1 0 0 1 1 1 1 Cullin family Peptidase_C48 PF02902.19 PIK46536.1 - 1.9e-15 57.3 1.2 4.5e-15 56.1 1.2 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain TFIID-31kDa PF02291.15 PIK46537.1 - 1.3e-32 112.4 0.0 1.7e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 PIK46537.1 - 1.2e-05 25.4 0.1 1.9e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 PIK46537.1 - 0.00081 19.7 0.1 0.0012 19.1 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 PIK46537.1 - 0.0024 18.2 0.0 0.0024 18.2 0.0 2.3 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK46537.1 - 0.021 15.1 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 PIK46537.1 - 0.22 11.6 0.0 0.45 10.6 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated Na_K-ATPase PF00287.18 PIK46538.1 - 1.4e-20 73.7 0.6 5.7e-12 45.4 0.8 2.0 2 0 0 2 2 2 2 Sodium / potassium ATPase beta chain Pyr_redox_dim PF02852.22 PIK46539.1 - 1.7e-25 89.4 0.1 2e-25 89.2 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 PIK46540.1 - 1.1e-63 215.2 0.7 1.4e-63 214.9 0.7 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK46540.1 - 1.6e-21 76.6 2.9 2e-19 69.9 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK46540.1 - 5.8e-17 61.9 0.0 7e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 PIK46540.1 - 8.9e-05 21.7 0.2 0.0014 17.8 0.1 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 PIK46540.1 - 0.00024 20.4 1.4 0.18 11.1 0.3 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 PIK46540.1 - 0.00029 20.3 0.1 0.00046 19.7 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 PIK46540.1 - 0.00051 20.0 3.2 0.0018 18.2 0.1 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 PIK46540.1 - 0.0025 17.2 0.4 1.6 8.1 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 PIK46540.1 - 0.011 16.2 0.1 3.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.17 PIK46540.1 - 0.014 14.6 0.3 0.034 13.4 0.3 1.6 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 PIK46540.1 - 0.018 14.1 2.4 0.038 13.1 1.1 1.9 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.6 PIK46540.1 - 0.028 14.6 1.4 0.27 11.5 0.7 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 PIK46540.1 - 0.029 13.1 1.4 0.65 8.6 0.3 2.8 3 0 0 3 3 3 0 HI0933-like protein DAO PF01266.24 PIK46540.1 - 0.09 12.3 0.8 0.61 9.6 0.4 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase K_oxygenase PF13434.6 PIK46540.1 - 0.094 11.8 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) UDPG_MGDP_dh_N PF03721.14 PIK46540.1 - 0.11 12.1 0.6 0.45 10.1 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain XdhC_C PF13478.6 PIK46540.1 - 0.18 12.3 0.0 6.6 7.3 0.0 2.2 2 0 0 2 2 2 0 XdhC Rossmann domain FAD_binding_3 PF01494.19 PIK46540.1 - 0.25 10.5 0.5 6.1 6.0 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain UNC80 PF15778.5 PIK46541.1 - 6.3e-60 202.0 0.0 2.7e-59 199.9 0.0 1.8 2 0 0 2 2 2 1 Cation channel complex component UNC80 Blt1 PF12754.7 PIK46541.1 - 0.16 12.3 0.7 0.47 10.8 0.0 2.0 2 0 0 2 2 2 0 Blt1 N-terminal domain PHD PF00628.29 PIK46546.1 - 3.8e-11 42.7 10.7 3.8e-11 42.7 10.7 2.4 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 PIK46546.1 - 3e-09 37.0 4.7 3e-09 37.0 4.7 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK46546.1 - 3e-06 27.1 5.7 3e-06 27.1 5.7 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK46546.1 - 4.5e-06 26.4 4.0 4.5e-06 26.4 4.0 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK46546.1 - 1.4e-05 24.8 5.2 1.4e-05 24.8 5.2 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK46546.1 - 2.7e-05 24.0 2.7 2.7e-05 24.0 2.7 2.6 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK46546.1 - 7.7e-05 22.5 3.9 7.7e-05 22.5 3.9 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK46546.1 - 0.00043 20.5 5.5 0.00043 20.5 5.5 3.1 2 2 0 2 2 2 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 PIK46546.1 - 0.0092 15.6 2.1 0.0092 15.6 2.1 3.1 2 1 0 2 2 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 PIK46546.1 - 0.016 15.0 7.4 0.016 15.0 7.4 3.4 3 1 1 4 4 3 0 Prokaryotic RING finger family 4 Nop14 PF04147.12 PIK46546.1 - 1.2 7.3 25.9 0.027 12.7 16.7 2.2 2 0 0 2 2 2 0 Nop14-like family FANCL_C PF11793.8 PIK46546.1 - 4.2 7.6 17.6 0.12 12.5 3.9 2.6 2 0 0 2 2 2 0 FANCL C-terminal domain Rieske PF00355.26 PIK46547.1 - 1.4e-11 44.2 0.1 2e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 PIK46547.1 - 3.1e-09 36.7 0.0 4.2e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Bac_DNA_binding PF00216.21 PIK46547.1 - 0.03 14.5 0.2 0.045 13.9 0.2 1.2 1 0 0 1 1 1 0 Bacterial DNA-binding protein KH_8 PF17903.1 PIK46548.1 - 2.4e-30 104.5 1.7 5.2e-30 103.4 0.0 2.4 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 PIK46548.1 - 0.00094 19.0 0.0 0.0024 17.6 0.0 1.7 1 0 0 1 1 1 1 KH domain TMEM132D_C PF15706.5 PIK46550.1 - 0.06 13.1 0.1 0.21 11.4 0.1 1.9 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term CrgA PF06781.12 PIK46552.1 - 1 9.5 4.7 1.2 9.2 3.0 2.2 1 1 0 1 1 1 0 Cell division protein CrgA CAF1 PF04857.20 PIK46553.1 - 1.6e-46 158.9 0.1 2e-46 158.7 0.1 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease R3H PF01424.22 PIK46553.1 - 0.0076 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 R3H domain DUF3784 PF12650.7 PIK46553.1 - 0.016 15.4 0.1 0.028 14.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) RNA_bind PF08675.11 PIK46554.1 - 7.4e-24 83.6 0.0 1.2e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 RNA binding domain CAF1 PF04857.20 PIK46554.1 - 0.0004 19.7 0.3 0.00065 19.0 0.0 1.5 2 0 0 2 2 2 1 CAF1 family ribonuclease RRM_1 PF00076.22 PIK46554.1 - 0.22 11.4 0.0 0.46 10.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trypsin PF00089.26 PIK46555.1 - 1.2e-22 80.8 0.0 1.5e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK46555.1 - 0.002 18.5 1.2 0.0034 17.8 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) CobT PF06213.12 PIK46556.1 - 1 8.7 8.3 1.1 8.5 8.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 PIK46556.1 - 2 6.6 9.0 2.1 6.5 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 PIK46556.1 - 2.7 6.0 14.7 2.6 6.1 14.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi SGT1 PF07093.11 PIK46556.1 - 4.4 5.6 6.5 4.8 5.5 6.5 1.0 1 0 0 1 1 1 0 SGT1 protein Utp14 PF04615.13 PIK46556.1 - 4.6 5.7 7.9 4.9 5.6 7.9 1.0 1 0 0 1 1 1 0 Utp14 protein DUF2457 PF10446.9 PIK46556.1 - 6.7 5.7 20.9 6.4 5.8 20.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 PIK46556.1 - 8.9 4.4 11.4 9.5 4.3 11.4 1.0 1 0 0 1 1 1 0 Nop14-like family SWIM PF04434.17 PIK46557.1 - 0.028 14.1 0.5 0.028 14.1 0.5 1.7 2 0 0 2 2 2 0 SWIM zinc finger HTH_Tnp_4 PF13613.6 PIK46557.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease DUF4776 PF16003.5 PIK46557.1 - 0.32 10.0 6.2 0.018 14.0 0.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) AAA_25 PF13481.6 PIK46559.1 - 0.0015 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK46559.1 - 0.0034 17.3 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Marek_A PF02124.15 PIK46559.1 - 0.014 15.2 0.6 0.022 14.6 0.6 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A DAP3 PF10236.9 PIK46559.1 - 0.044 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 C1-set PF07654.15 PIK46559.1 - 0.049 14.0 0.3 0.097 13.1 0.3 1.4 1 0 0 1 1 1 0 Immunoglobulin C1-set domain DUF4364 PF14277.6 PIK46559.1 - 0.049 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) GOLD_2 PF13897.6 PIK46559.1 - 0.075 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking AAA_16 PF13191.6 PIK46559.1 - 0.1 13.0 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Adeno_E3_CR2 PF02439.15 PIK46559.1 - 0.38 10.5 9.0 0.72 9.7 9.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NACHT PF05729.12 PIK46560.1 - 2.5e-09 37.3 0.1 2.5e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain GPI2 PF06432.11 PIK46560.1 - 0.094 12.1 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase RVT_1 PF00078.27 PIK46561.1 - 5.3e-16 58.8 0.1 6.4e-16 58.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK46561.1 - 0.088 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) RT_RNaseH_2 PF17919.1 PIK46562.1 - 5.1e-37 125.9 0.0 8.1e-37 125.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46562.1 - 3.6e-36 123.6 0.0 4.8e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MULE PF10551.9 PIK46563.1 - 8.1e-07 29.4 0.0 1.9e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Bacillus_HBL PF05791.11 PIK46563.1 - 0.053 13.3 1.5 0.16 11.8 0.2 2.3 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DDE_Tnp_IS240 PF13610.6 PIK46563.1 - 0.067 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 DDE domain HTH_Tnp_4 PF13613.6 PIK46563.1 - 0.078 12.7 0.2 0.32 10.8 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease RVT_1 PF00078.27 PIK46566.1 - 2e-20 73.3 0.1 3.2e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAIM1 PF06905.13 PIK46566.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Fas apoptotic inhibitory molecule (FAIM1) ArgoMid PF16487.5 PIK46566.1 - 0.055 13.7 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 Mid domain of argonaute RVT_1 PF00078.27 PIK46567.1 - 0.00062 19.4 0.6 0.0034 16.9 0.3 2.3 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK46567.1 - 0.057 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Med18 protein TMEM154 PF15102.6 PIK46567.1 - 0.084 12.8 0.4 0.13 12.1 0.4 1.3 1 0 0 1 1 1 0 TMEM154 protein family RT_RNaseH_2 PF17919.1 PIK46568.1 - 4.8e-34 116.4 0.0 9e-34 115.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46568.1 - 4.9e-32 110.3 0.0 1e-31 109.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46568.1 - 5.8e-24 84.8 0.1 8.6e-24 84.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 3HCDH_N PF02737.18 PIK46570.1 - 1.6e-38 132.4 0.5 1.1e-28 100.3 0.4 2.1 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 PIK46570.1 - 4.7e-17 62.4 0.1 2.5e-16 60.1 0.0 2.3 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain AlaDh_PNT_C PF01262.21 PIK46570.1 - 2e-07 30.5 2.9 3.1e-07 29.9 2.9 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 PIK46570.1 - 1.9e-06 28.3 0.4 5.1e-06 27.0 0.4 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK46570.1 - 3.3e-06 26.6 0.9 4.8e-06 26.0 0.9 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 PIK46570.1 - 8.4e-05 23.0 0.8 0.00015 22.2 0.8 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 PIK46570.1 - 0.00018 21.8 0.8 0.00038 20.7 0.8 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 PIK46570.1 - 0.00029 21.0 1.8 0.0011 19.2 1.8 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 PIK46570.1 - 0.00036 21.1 3.7 0.0029 18.1 3.7 2.1 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 PIK46570.1 - 0.00051 20.1 0.8 0.0014 18.7 0.8 1.7 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 PIK46570.1 - 0.00051 19.4 0.4 0.00076 18.8 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 PIK46570.1 - 0.00079 19.1 3.0 0.0023 17.5 3.0 1.7 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain YjeF_N PF03853.15 PIK46570.1 - 0.0013 18.7 0.3 0.0045 16.9 0.3 1.8 1 1 0 1 1 1 1 YjeF-related protein N-terminus DAO PF01266.24 PIK46570.1 - 0.0015 18.2 2.0 0.0027 17.3 2.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK46570.1 - 0.0033 17.6 0.3 0.0065 16.7 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK46570.1 - 0.0043 16.4 1.3 0.0061 15.8 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.6 PIK46570.1 - 0.014 15.9 0.0 0.022 15.3 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain HI0933_like PF03486.14 PIK46570.1 - 0.021 13.6 0.5 0.032 12.9 0.5 1.3 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 PIK46570.1 - 0.03 14.6 0.6 0.054 13.8 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain DFP PF04127.15 PIK46570.1 - 0.036 13.9 1.4 0.081 12.8 1.4 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein GIDA PF01134.22 PIK46570.1 - 0.041 12.9 1.7 0.058 12.5 1.4 1.4 1 1 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 PIK46570.1 - 0.053 12.6 0.1 0.059 12.4 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 PIK46570.1 - 0.19 11.8 3.1 0.73 9.9 0.6 2.3 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 PIK46570.1 - 0.79 9.0 4.7 0.22 10.8 2.0 1.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase Bax1-I PF01027.20 PIK46571.1 - 3.4e-28 98.9 15.2 5.4e-28 98.3 15.2 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ASC PF00858.24 PIK46572.1 - 6.8e-23 81.3 0.2 8.8e-23 81.0 0.2 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.24 PIK46573.1 - 8.1e-25 87.7 1.1 9.8e-25 87.4 1.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Cadherin PF00028.17 PIK46574.1 - 3.8e-17 62.5 5.2 1.3e-06 28.8 0.0 3.5 4 0 0 4 4 4 3 Cadherin domain Minor_capsid_3 PF12691.7 PIK46574.1 - 0.014 15.8 2.3 0.043 14.2 0.7 2.2 1 1 1 2 2 2 0 Minor capsid protein from bacteriophage Cadherin PF00028.17 PIK46575.1 - 2.4e-33 114.4 0.1 8.9e-16 58.1 0.0 2.1 2 0 0 2 2 2 2 Cadherin domain Cadherin_3 PF16184.5 PIK46575.1 - 0.00025 21.0 0.2 0.33 11.0 0.0 3.4 3 1 0 3 3 3 2 Cadherin-like Cadherin_4 PF17803.1 PIK46575.1 - 0.0014 19.2 11.3 0.004 17.7 1.9 3.4 3 1 0 3 3 3 2 Bacterial cadherin-like domain Cadherin_2 PF08266.12 PIK46575.1 - 0.0024 17.7 0.2 0.33 10.8 0.1 3.1 3 1 0 3 3 3 1 Cadherin-like Big_9 PF17963.1 PIK46575.1 - 0.033 14.9 10.2 0.17 12.7 2.1 3.3 3 0 0 3 3 3 0 Bacterial Ig domain Cadherin_pro PF08758.11 PIK46575.1 - 0.075 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Cadherin prodomain like Cadherin PF00028.17 PIK46576.1 - 2.3e-58 194.7 14.5 3.6e-17 62.6 0.0 4.2 4 0 0 4 4 4 4 Cadherin domain Cadherin_2 PF08266.12 PIK46576.1 - 1.1e-07 31.5 0.1 0.027 14.3 0.0 4.1 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 PIK46576.1 - 1.2e-07 31.7 8.8 0.055 13.5 0.1 4.0 4 0 0 4 4 4 3 Cadherin-like Pertactin PF03212.14 PIK46576.1 - 0.00077 19.4 0.5 0.0027 17.6 0.2 2.1 1 1 1 2 2 2 1 Pertactin RET_CLD1 PF17756.1 PIK46576.1 - 0.0036 17.6 0.0 1.1 9.5 0.0 3.7 4 0 0 4 4 4 1 RET Cadherin like domain 1 Pox_M2 PF04887.12 PIK46576.1 - 0.095 12.2 0.2 0.095 12.2 0.2 1.9 2 1 0 2 2 2 0 Poxvirus M2 protein He_PIG PF05345.12 PIK46576.1 - 5.9 7.2 12.9 15 5.9 0.0 4.8 6 0 0 6 6 6 0 Putative Ig domain Cadherin PF00028.17 PIK46577.1 - 1.2e-15 57.7 3.3 4.3e-09 36.7 0.1 2.9 2 0 0 2 2 2 2 Cadherin domain CaM_bdg_C0 PF10562.9 PIK46577.1 - 0.032 14.3 0.6 0.065 13.3 0.6 1.4 1 0 0 1 1 1 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit UPF0728 PF15092.6 PIK46578.1 - 8.5e-37 124.9 0.0 9.5e-37 124.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0728 F-box-like PF12937.7 PIK46579.1 - 5.3e-06 26.2 0.1 1.8e-05 24.5 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK46579.1 - 0.00035 20.4 2.2 0.015 15.2 0.4 3.0 2 0 0 2 2 2 2 F-box domain DUF3091 PF11291.8 PIK46580.1 - 0.015 15.4 1.9 0.071 13.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) CC2-LZ PF16516.5 PIK46581.1 - 1.6e-07 31.6 2.2 1.6e-07 31.6 2.2 5.0 3 1 3 6 6 6 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Death PF00531.22 PIK46581.1 - 0.0021 18.2 0.1 0.011 15.9 0.1 2.2 1 0 0 1 1 1 1 Death domain RNA_helicase PF00910.22 PIK46581.1 - 0.077 13.4 0.2 4.8 7.6 0.0 3.3 3 0 0 3 3 3 0 RNA helicase CHDCT2 PF08074.11 PIK46581.1 - 0.41 10.8 9.5 1.5 9.0 9.5 2.0 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Speriolin_N PF15058.6 PIK46581.1 - 1.6 8.8 8.0 0.5 10.4 0.5 2.8 2 1 1 3 3 3 0 Speriolin N terminus Lipase_GDSL_2 PF13472.6 PIK46582.1 - 3.5e-05 24.3 0.0 4.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Ribosomal_S27e PF01667.17 PIK46583.1 - 7.8e-27 92.8 2.0 1.3e-26 92.1 2.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S27 RAMPs PF03787.15 PIK46583.1 - 0.022 14.8 0.0 0.026 14.6 0.0 1.1 1 0 0 1 1 1 0 RAMP superfamily Aminotran_5 PF00266.19 PIK46584.1 - 4.8e-41 140.9 0.0 1.2e-40 139.6 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK46584.1 - 0.00023 20.5 0.0 0.00039 19.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4162 PF13732.6 PIK46585.1 - 3.6 8.4 7.2 26 5.6 0.2 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4162) R3H PF01424.22 PIK46586.1 - 1.1e-11 44.5 0.5 2.5e-11 43.4 0.1 1.9 2 0 0 2 2 2 1 R3H domain Ras PF00071.22 PIK46587.1 - 7.5e-39 132.9 0.5 1e-38 132.5 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK46587.1 - 1.3e-12 48.0 0.1 2.6e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK46587.1 - 1.3e-05 24.8 0.5 1.9e-05 24.2 0.5 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Phage_holin_6_1 PF09682.10 PIK46587.1 - 0.053 13.9 0.1 0.096 13.1 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF3963 PF13124.6 PIK46587.1 - 0.68 10.0 4.4 0.5 10.4 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) WSC PF01822.19 PIK46588.1 - 8.4e-21 74.0 24.2 1.2e-10 41.4 8.8 2.1 2 0 0 2 2 2 2 WSC domain DUF4953 PF16313.5 PIK46588.1 - 0.25 10.5 0.0 0.37 10.0 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Bee_toxin PF17454.2 PIK46588.1 - 2 8.5 6.2 1.8 8.6 0.2 3.2 2 1 1 3 3 3 0 Honey bee toxin WSC PF01822.19 PIK46589.1 - 8.8e-17 61.1 32.0 4.6e-09 36.3 9.9 2.9 3 0 0 3 3 3 2 WSC domain RNA_pol_Rpb1_R PF05001.13 PIK46589.1 - 0.00052 20.2 24.2 1.7 9.1 0.2 8.1 8 1 1 9 9 9 3 RNA polymerase Rpb1 C-terminal repeat WSC PF01822.19 PIK46590.1 - 1.1e-17 64.0 28.3 1.4e-09 38.0 8.8 2.8 3 0 0 3 3 3 2 WSC domain RNA_pol_Rpb1_R PF05001.13 PIK46590.1 - 2.5e-07 30.7 63.1 2.5 8.6 0.2 18.8 16 6 4 20 20 20 9 RNA polymerase Rpb1 C-terminal repeat BH3 PF15285.6 PIK46590.1 - 0.00026 20.7 58.3 70 3.3 0.1 19.9 21 0 0 21 21 21 0 Beclin-1 BH3 domain, Bcl-2-interacting DUF2529 PF10740.9 PIK46591.1 - 0.02 14.5 0.2 0.095 12.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2529) SET PF00856.28 PIK46592.1 - 1.4e-08 35.3 3.0 3.3e-07 30.9 0.0 3.2 4 0 0 4 4 4 1 SET domain RXT2_N PF08595.11 PIK46592.1 - 8 6.5 12.7 8.8 6.3 3.8 3.1 3 0 0 3 3 3 0 RXT2-like, N-terminal SH3_15 PF18346.1 PIK46593.1 - 1.5e-43 147.0 9.4 1.2e-22 80.0 0.0 3.4 4 0 0 4 4 4 2 Mind bomb SH3 repeat domain MIB_HERC2 PF06701.13 PIK46593.1 - 3.1e-31 107.4 15.2 7.1e-26 90.3 4.6 3.4 3 0 0 3 3 3 2 Mib_herc2 ZZ PF00569.17 PIK46593.1 - 1.6e-10 40.7 7.7 2.9e-10 39.8 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Ank_4 PF13637.6 PIK46594.1 - 1.8e-25 89.0 1.4 7e-11 42.4 0.3 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK46594.1 - 5.4e-24 84.6 0.7 2e-14 54.0 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK46594.1 - 2e-22 78.9 3.2 1.6e-10 41.0 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK46594.1 - 9e-21 73.3 3.3 0.00013 22.2 0.2 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 PIK46594.1 - 8e-18 62.7 0.5 0.042 14.4 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Peptidase_M43 PF05572.13 PIK46594.1 - 0.077 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M16 PF00675.20 PIK46594.1 - 0.084 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) Laminin_G_2 PF02210.24 PIK46595.1 - 2.7e-23 82.9 0.0 5.4e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK46595.1 - 8.7e-14 51.9 0.0 1.6e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Syndecan PF01034.20 PIK46595.1 - 2.3e-05 24.2 0.0 4.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain TGF_beta_GS PF08515.12 PIK46595.1 - 0.033 13.7 1.5 3 7.4 1.0 2.4 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif AAA_16 PF13191.6 PIK46596.1 - 0.13 12.7 0.1 0.27 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain TPR_12 PF13424.6 PIK46597.1 - 4.6e-05 23.6 8.4 0.32 11.3 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46597.1 - 0.00083 19.4 0.0 0.18 12.1 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK46597.1 - 0.001 19.0 1.4 0.28 11.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46597.1 - 0.0017 18.1 0.1 0.02 14.7 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46597.1 - 0.01 16.6 2.1 32 5.7 0.4 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK46597.1 - 0.63 10.7 2.7 51 4.6 1.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3504 PF12012.8 PIK46599.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) zf-C2H2_jaz PF12171.8 PIK46600.1 - 0.011 16.0 3.3 0.018 15.3 0.1 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 PIK46600.1 - 0.012 16.0 5.0 0.097 13.2 1.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK46600.1 - 0.095 13.6 9.3 0.13 13.2 0.8 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-ribbon_3 PF13248.6 PIK46600.1 - 0.14 11.6 1.7 1.1 8.7 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zf-ACC PF17848.1 PIK46600.1 - 0.2 11.8 1.6 1.5 9.0 0.1 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn_ribbon_recom PF13408.6 PIK46600.1 - 0.75 10.4 3.7 0.6 10.7 0.4 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn-ribbon_8 PF09723.10 PIK46600.1 - 1.2 9.3 7.7 1.2 9.3 0.8 2.6 1 1 1 2 2 2 0 Zinc ribbon domain RT_RNaseH_2 PF17919.1 PIK46601.1 - 1e-36 124.9 0.0 1.8e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46601.1 - 5.6e-33 113.4 0.0 1.1e-32 112.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46601.1 - 5.8e-29 101.2 0.0 1e-28 100.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46601.1 - 5.4e-22 78.2 0.0 1.4e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46601.1 - 8.5e-17 61.0 2.4 1.7e-16 60.1 2.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46601.1 - 0.024 14.4 0.0 0.068 13.0 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Ldh_2 PF02615.14 PIK46601.1 - 0.19 10.8 0.0 0.36 9.9 0.0 1.4 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase gag-asp_proteas PF13975.6 PIK46602.1 - 1.7e-09 38.1 0.0 2.8e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK46602.1 - 8.1e-07 29.6 0.0 1.6e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK46602.1 - 0.0013 19.0 0.1 0.0045 17.3 0.1 1.9 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 PIK46602.1 - 0.01 15.6 0.4 0.05 13.4 0.4 1.9 1 1 0 1 1 1 0 Aspartyl protease DUF5062 PF16691.5 PIK46602.1 - 0.064 13.4 0.0 0.16 12.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5062) Asp PF00026.23 PIK46602.1 - 0.065 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic aspartyl protease Sulfotransfer_1 PF00685.27 PIK46606.1 - 2e-21 76.7 1.7 2.2e-21 76.5 1.7 1.0 1 0 0 1 1 1 1 Sulfotransferase domain B56 PF01603.20 PIK46607.1 - 5e-199 661.5 9.7 6e-199 661.2 9.7 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) IMD PF08397.11 PIK46607.1 - 0.027 13.8 2.8 0.053 12.9 2.8 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain ER PF01133.17 PIK46608.1 - 0.0025 17.8 1.6 0.016 15.2 0.3 2.6 2 1 0 2 2 2 1 Enhancer of rudimentary Hairy_orange PF07527.13 PIK46608.1 - 0.092 13.0 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 Hairy Orange RVT_1 PF00078.27 PIK46609.1 - 1.5e-07 31.1 0.0 1.9e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HEPN_Swt1 PF18731.1 PIK46610.1 - 0.021 15.2 0.3 0.025 14.9 0.3 1.1 1 0 0 1 1 1 0 Swt1-like HEPN RNA_pol_I_TF PF04090.12 PIK46610.1 - 0.085 12.3 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific initiation factor DnaJ_CXXCXGXG PF00684.19 PIK46611.1 - 0.28 11.6 40.2 0.93 9.9 5.0 4.1 2 1 2 4 4 4 0 DnaJ central domain zf-H2C2_2 PF13465.6 PIK46612.1 - 2.9e-29 100.2 61.4 1.1e-07 32.0 4.8 9.6 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK46612.1 - 1.2e-27 94.8 84.7 6e-05 23.3 2.8 9.8 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK46612.1 - 5.6e-17 61.0 80.8 0.0099 16.7 1.3 9.8 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK46612.1 - 3.1e-06 27.3 55.3 0.0019 18.5 0.7 9.1 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding Homeodomain PF00046.29 PIK46612.1 - 8.2e-06 25.6 0.4 2.8e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 Homeodomain zf-met PF12874.7 PIK46612.1 - 0.00048 20.4 1.9 0.00048 20.4 1.9 9.1 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK46612.1 - 0.001 18.8 1.7 0.001 18.8 1.7 5.5 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 PIK46612.1 - 0.0078 16.2 0.5 0.0078 16.2 0.5 8.7 8 1 0 8 8 8 1 C2H2-type zinc finger 7tm_1 PF00001.21 PIK46613.1 - 3.4e-09 36.4 0.0 4.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Laminin_EGF PF00053.24 PIK46614.1 - 4e-05 23.7 14.8 4e-05 23.7 14.8 7.6 2 1 5 7 7 7 2 Laminin EGF domain TMEM51 PF15345.6 PIK46614.1 - 0.017 14.9 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM154 PF15102.6 PIK46614.1 - 0.041 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family EGF_2 PF07974.13 PIK46614.1 - 0.89 10.0 114.0 0.086 13.2 15.7 11.4 6 6 2 8 8 8 0 EGF-like domain TCR PF03638.15 PIK46615.1 - 0.00032 20.9 24.6 0.00078 19.7 24.6 1.7 1 0 0 1 1 1 1 Tesmin/TSO1-like CXC domain, cysteine-rich domain GPCR_chapero_1 PF11904.8 PIK46616.1 - 1.3e-54 185.8 3.0 1.1e-53 182.7 3.0 2.0 1 1 0 1 1 1 1 GPCR-chaperone Ank PF00023.30 PIK46616.1 - 4.9e-09 36.2 1.9 3.6e-07 30.4 1.3 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 PIK46616.1 - 1.5e-08 35.1 0.1 2.9e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK46616.1 - 3.2e-08 34.0 0.2 6.9e-08 32.9 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46616.1 - 4.7e-08 32.7 0.2 0.00066 19.9 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 PIK46616.1 - 5.9e-05 23.3 0.2 0.00011 22.4 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Cys_Met_Meta_PP PF01053.20 PIK46617.1 - 2.3e-102 342.4 0.0 2.7e-102 342.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Cys_Met_Meta_PP PF01053.20 PIK46618.1 - 5.9e-39 133.7 0.0 7.1e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PGM_PMM_II PF02879.16 PIK46618.1 - 0.15 12.7 0.0 0.32 11.6 0.0 1.6 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Sulfotransfer_2 PF03567.14 PIK46620.1 - 9.6e-05 22.4 0.9 0.00052 20.0 0.0 2.4 3 1 0 3 3 3 1 Sulfotransferase family EGF_MSP1_1 PF12946.7 PIK46620.1 - 0.0053 16.8 0.5 0.032 14.3 0.3 2.3 2 0 0 2 2 2 1 MSP1 EGF domain 1 Adaptin_N PF01602.20 PIK46621.1 - 8.2e-141 470.1 12.9 1.1e-140 469.7 12.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3D1 PF06375.11 PIK46621.1 - 1.7e-38 132.4 13.8 1.7e-38 132.4 13.8 4.0 2 1 2 4 4 4 1 AP-3 complex subunit delta-1 Cnd1 PF12717.7 PIK46621.1 - 5e-15 55.9 7.1 2.8e-10 40.5 0.0 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK46621.1 - 3.1e-05 24.3 0.4 0.26 11.7 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 PIK46621.1 - 5.9e-05 23.0 0.4 1.4 9.3 0.0 4.3 3 0 0 3 3 3 2 HEAT repeat RTP1_C1 PF10363.9 PIK46621.1 - 0.00071 19.7 1.7 1.1 9.5 0.8 3.2 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 PIK46621.1 - 0.017 15.5 1.5 0.71 10.3 0.2 3.1 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.7 PIK46621.1 - 0.091 13.4 0.1 0.97 10.1 0.1 2.7 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region BTB_2 PF02214.22 PIK46623.1 - 3.1e-08 33.9 0.3 7.8e-08 32.6 0.3 1.7 1 1 0 1 1 1 1 BTB/POZ domain DUF5487 PF17589.2 PIK46623.1 - 0.0057 16.9 0.1 0.0092 16.2 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5487) BTB_2 PF02214.22 PIK46624.1 - 1.5e-08 34.9 0.2 7e-08 32.7 0.2 2.2 1 1 0 1 1 1 1 BTB/POZ domain DUF5487 PF17589.2 PIK46624.1 - 0.019 15.2 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5487) DUF3808 PF10300.9 PIK46625.1 - 2.5e-88 296.9 0.3 3.1e-88 296.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) MIT PF04212.18 PIK46625.1 - 0.073 13.2 0.2 6.7 6.9 0.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Rib_hydrolayse PF02267.17 PIK46627.1 - 4.6e-59 199.7 0.0 5.6e-59 199.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase DUF3775 PF12616.8 PIK46627.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) DUF2252 PF10009.9 PIK46628.1 - 0.19 10.7 5.0 0.25 10.4 5.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF5401 PF17380.2 PIK46628.1 - 0.5 8.4 27.3 0.62 8.1 27.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) V_ATPase_I PF01496.19 PIK46628.1 - 1.9 6.3 11.0 2.1 6.2 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 PIK46628.1 - 4 6.9 12.5 5.5 6.5 12.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit z-alpha PF02295.17 PIK46628.1 - 5.3 7.2 8.2 0.98 9.5 3.2 2.3 2 1 1 3 3 3 0 Adenosine deaminase z-alpha domain Lectin_N PF03954.14 PIK46628.1 - 5.8 6.7 11.1 0.77 9.5 3.9 2.3 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain XPG_N PF00752.17 PIK46630.1 - 1.7e-28 99.0 0.0 4.4e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 PIK46630.1 - 7.4e-24 83.9 1.5 2.9e-23 82.0 0.0 2.8 2 0 0 2 2 2 1 XPG I-region MFS_1 PF07690.16 PIK46631.1 - 1.5e-31 109.7 27.6 1.5e-31 109.7 27.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 PIK46631.1 - 7.4e-12 44.3 20.2 3.2e-05 22.4 0.4 4.1 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 PIK46631.1 - 3.5e-11 42.6 8.8 3.5e-11 42.6 8.8 2.3 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 PIK46631.1 - 9.8e-07 27.7 19.8 0.0014 17.2 1.7 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein SPW PF03779.14 PIK46631.1 - 0.44 10.2 0.0 0.44 10.2 0.0 3.8 5 0 0 5 5 5 0 SPW repeat Ribosomal_L16 PF00252.18 PIK46632.1 - 4.7e-30 104.3 0.5 6.1e-30 103.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Thioredoxin_8 PF13905.6 PIK46632.1 - 0.008 16.5 0.3 0.02 15.2 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like ERM PF00769.19 PIK46633.1 - 1.2e-06 28.5 59.9 2e-05 24.5 41.3 2.0 1 1 1 2 2 2 2 Ezrin/radixin/moesin family GAS PF13851.6 PIK46633.1 - 1e-05 25.0 51.4 0.0053 16.1 34.6 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK46633.1 - 0.00052 20.5 58.9 3.1e+03 -1.4 58.9 2.5 1 1 0 1 1 1 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 PIK46633.1 - 0.0026 18.3 53.2 0.013 16.0 20.6 3.1 1 1 2 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 TPD52 PF04201.15 PIK46633.1 - 0.0042 16.7 39.0 0.46 10.1 10.5 3.6 1 1 3 4 4 4 2 Tumour protein D52 family PilA4 PF18682.1 PIK46633.1 - 0.012 16.0 10.2 5.3 7.5 0.1 5.0 2 1 3 5 5 5 0 Pilin A4 DUF4472 PF14739.6 PIK46633.1 - 0.013 16.2 43.7 0.76 10.5 15.3 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) AAA_13 PF13166.6 PIK46633.1 - 0.042 12.5 28.5 0.059 12.0 28.5 1.3 1 0 0 1 1 1 0 AAA domain T3SSipB PF16535.5 PIK46633.1 - 0.088 13.3 29.7 0.16 12.4 6.7 2.9 1 1 1 2 2 2 0 Type III cell invasion protein SipB Fez1 PF06818.15 PIK46633.1 - 0.092 13.2 46.1 0.45 10.9 45.0 2.0 1 1 0 1 1 1 0 Fez1 Flp_C PF05202.12 PIK46633.1 - 0.12 11.9 0.2 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 Recombinase Flp protein DUF4743 PF15916.5 PIK46633.1 - 0.3 11.1 9.8 1.8 8.5 1.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4743) Lebercilin PF15619.6 PIK46633.1 - 0.39 10.3 51.6 0.31 10.7 17.2 2.9 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SOGA PF11365.8 PIK46633.1 - 0.63 11.2 38.8 1.7 9.8 2.7 4.1 1 1 3 4 4 4 0 Protein SOGA ATG16 PF08614.11 PIK46633.1 - 0.97 9.6 53.0 0.17 12.1 34.3 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4600 PF15372.6 PIK46633.1 - 0.98 9.9 39.1 1.2 9.5 10.8 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) DUF1664 PF07889.12 PIK46633.1 - 1 9.4 24.2 2 8.5 10.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Nsp1_C PF05064.13 PIK46633.1 - 1.1 9.1 39.4 0.76 9.6 6.7 3.7 1 1 3 4 4 4 0 Nsp1-like C-terminal region TACC_C PF05010.14 PIK46633.1 - 1.8 8.3 43.3 1.5 8.6 21.5 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FPP PF05911.11 PIK46633.1 - 2.3 6.3 42.6 3.8 5.6 6.0 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil JIP_LZII PF16471.5 PIK46633.1 - 2.5 8.3 40.3 0.53 10.5 7.9 4.4 2 2 3 5 5 5 0 JNK-interacting protein leucine zipper II T2SSN PF01203.19 PIK46633.1 - 2.8 8.1 9.8 5.9 7.1 1.1 3.0 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein N KASH_CCD PF14662.6 PIK46633.1 - 2.8 7.7 50.7 3.9 7.3 24.7 2.8 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Nmad4 PF18756.1 PIK46633.1 - 3.3 8.1 8.4 25 5.3 0.3 3.7 1 1 3 4 4 4 0 Nucleotide modification associated domain 4 DUF3450 PF11932.8 PIK46633.1 - 8.9 5.5 43.8 5.5 6.2 21.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FapA PF03961.13 PIK46633.1 - 9.9 4.6 36.2 3.8 6.0 14.2 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A ZU5 PF00791.20 PIK46634.1 - 0.097 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 ZU5 domain Scytalone_dh PF02982.14 PIK46635.1 - 0.019 14.8 0.1 0.073 12.9 0.0 1.9 2 0 0 2 2 2 0 Scytalone dehydratase TRAP_beta PF05753.14 PIK46635.1 - 0.045 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) Homez PF11569.8 PIK46635.1 - 0.066 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez ZU5 PF00791.20 PIK46636.1 - 5.3e-09 36.3 0.0 1.5e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 ZU5 domain DUF2054 PF10218.9 PIK46637.1 - 8.1e-24 84.2 12.9 1e-23 83.9 12.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) Ctr PF04145.15 PIK46638.1 - 4e-18 66.4 3.3 5.6e-18 66.0 3.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF2897 PF11446.8 PIK46638.1 - 0.043 13.7 1.3 0.1 12.5 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) DUF5592 PF17332.2 PIK46638.1 - 0.25 11.9 0.2 0.25 11.9 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5592) MFS_1 PF07690.16 PIK46639.1 - 2.7e-15 56.1 26.5 1.5e-10 40.6 13.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HalOD2 PF18547.1 PIK46639.1 - 0.11 12.4 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 Halobacterial output domain 2 DUF2198 PF09964.9 PIK46639.1 - 3.4 7.8 13.6 5.7 7.1 3.3 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2198) ZU5 PF00791.20 PIK46640.1 - 1.3e-14 54.4 0.0 6.8e-09 36.0 0.0 2.9 2 0 0 2 2 2 2 ZU5 domain CSN5_C PF18323.1 PIK46640.1 - 0.091 13.7 0.5 1.2 10.0 0.1 2.3 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain WD40 PF00400.32 PIK46642.1 - 1.3e-12 48.0 8.5 1.9e-06 28.5 0.1 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK46642.1 - 0.00067 19.9 0.2 0.76 10.1 0.0 3.8 2 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK46642.1 - 0.0049 15.9 4.8 0.026 13.5 0.7 3.3 2 2 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2140 PF09911.9 PIK46642.1 - 0.01 15.4 0.2 0.022 14.3 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2140) LapA_dom PF06305.11 PIK46642.1 - 0.015 15.1 0.6 0.036 13.9 0.6 1.6 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain eIF2A PF08662.11 PIK46642.1 - 0.021 14.7 0.1 0.35 10.7 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 PIK46642.1 - 0.72 7.8 5.8 2 6.3 0.0 2.8 2 1 1 3 3 3 0 IKI3 family Neur_chan_memb PF02932.16 PIK46643.1 - 3e-66 223.9 0.2 3.9e-66 223.5 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK46643.1 - 5.1e-53 179.7 3.2 8.7e-53 179.0 3.2 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF417 PF04224.12 PIK46643.1 - 0.33 10.5 4.7 0.89 9.1 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF417 MFS_1 PF07690.16 PIK46643.1 - 1.9 7.3 12.3 1.4 7.7 9.5 1.8 2 0 0 2 2 2 0 Major Facilitator Superfamily DUF2417 PF10329.9 PIK46643.1 - 6.3 6.2 9.7 9.5 5.6 8.2 2.0 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Neur_chan_memb PF02932.16 PIK46644.1 - 5.4e-70 236.1 4.8 6.9e-70 235.8 4.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK46644.1 - 1.3e-32 113.0 0.1 2.1e-32 112.3 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Cauli_AT PF03233.13 PIK46644.1 - 0.0043 17.0 1.2 0.0068 16.3 1.2 1.2 1 0 0 1 1 1 1 Aphid transmission protein DUF417 PF04224.12 PIK46644.1 - 0.028 14.0 3.9 0.05 13.2 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF417 PHO4 PF01384.20 PIK46644.1 - 2 7.4 4.8 2.7 6.9 4.6 1.4 1 1 0 1 1 1 0 Phosphate transporter family Amidinotransf PF02274.17 PIK46645.1 - 0.066 12.3 0.1 0.34 10.0 0.0 1.8 2 0 0 2 2 2 0 Amidinotransferase 5HT_transport_N PF03491.13 PIK46645.1 - 0.34 11.2 1.7 0.6 10.4 1.7 1.3 1 0 0 1 1 1 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus V-set PF07686.17 PIK46646.1 - 0.00015 21.9 0.0 0.00042 20.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK46646.1 - 0.003 17.7 0.2 0.016 15.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK46646.1 - 0.0031 18.1 0.4 0.033 14.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Herpes_gE PF02480.16 PIK46646.1 - 0.051 12.3 0.1 0.057 12.2 0.1 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E V-set PF07686.17 PIK46647.1 - 3.7e-13 49.6 5.1 4.5e-06 26.8 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK46647.1 - 1.6e-09 38.2 5.8 0.00081 19.9 0.0 4.4 4 1 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK46647.1 - 1.1e-05 25.4 2.0 0.0035 17.4 0.0 3.8 3 1 1 4 4 4 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK46647.1 - 0.0015 18.5 1.0 2.6 8.2 0.0 3.5 3 1 1 4 4 4 2 Immunoglobulin I-set domain ig PF00047.25 PIK46647.1 - 0.0092 16.1 4.9 0.023 14.9 0.3 3.4 4 0 0 4 4 4 1 Immunoglobulin domain Receptor_2B4 PF11465.8 PIK46647.1 - 0.024 14.8 0.1 0.2 11.8 0.0 2.3 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Ig_6 PF18452.1 PIK46647.1 - 0.062 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK46648.1 - 1.2e-08 34.6 0.3 1.2e-08 34.6 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46648.1 - 0.00083 18.8 0.1 0.00083 18.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF2507 PF10702.9 PIK46648.1 - 0.047 13.6 0.0 0.054 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2507) Pkinase_Tyr PF07714.17 PIK46649.1 - 3e-30 105.4 0.0 7.3e-30 104.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46649.1 - 6.4e-14 52.0 0.0 1.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK46649.1 - 1.1e-05 25.9 0.3 0.09 13.4 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK46649.1 - 5.2e-05 23.2 0.0 0.00036 20.5 0.0 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK46649.1 - 0.00099 19.4 0.5 0.21 11.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK46649.1 - 0.0019 18.2 0.4 0.48 10.5 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.15 PIK46649.1 - 0.024 15.0 1.0 0.051 13.9 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK46649.1 - 0.081 12.5 0.3 0.47 10.1 0.1 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Ig_4 PF16680.5 PIK46649.1 - 1.1 9.6 3.9 9 6.6 2.3 2.8 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK46650.1 - 4.3e-11 42.9 0.1 0.0053 16.9 0.0 3.4 2 1 1 3 3 3 3 Immunoglobulin V-set domain I-set PF07679.16 PIK46650.1 - 2.6e-06 27.4 0.0 0.22 11.6 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin I-set domain ig PF00047.25 PIK46650.1 - 6e-05 23.2 0.1 2 8.7 0.0 4.4 4 0 0 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK46650.1 - 0.00034 21.2 2.3 7.9 7.2 0.0 5.0 4 1 1 5 5 5 1 Immunoglobulin domain Herpes_gE PF02480.16 PIK46650.1 - 0.014 14.1 1.2 2.6 6.7 0.1 2.9 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E XPG_I_2 PF12813.7 PIK46651.1 - 1.9e-12 47.2 0.0 2.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 PIK46651.1 - 4.9e-09 36.6 0.0 8.2e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 XPG N-terminal domain F-box-like PF12937.7 PIK46652.1 - 2e-10 40.4 3.1 6e-10 38.9 3.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK46652.1 - 1.5e-09 37.4 0.3 3.5e-09 36.3 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 PIK46652.1 - 9.8e-06 25.4 0.1 2.3e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 F-box Arf PF00025.21 PIK46652.1 - 0.0014 18.1 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Elongin_A PF06881.11 PIK46652.1 - 0.025 15.1 0.1 0.053 14.0 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pkinase PF00069.25 PIK46654.1 - 5.3e-76 255.5 0.0 8.6e-76 254.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46654.1 - 7.9e-43 146.6 0.0 1.2e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 PIK46654.1 - 1.5e-13 51.2 0.6 6.1e-13 49.3 0.3 2.2 2 1 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 PIK46654.1 - 7.3e-09 35.4 0.0 1.3e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 PIK46654.1 - 2.8e-05 23.8 0.7 6e-05 22.7 0.7 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 PIK46654.1 - 0.0002 20.4 1.0 0.00039 19.5 1.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Shikimate_DH PF01488.20 PIK46654.1 - 0.012 15.7 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase YukC PF10140.9 PIK46654.1 - 0.014 14.2 0.1 0.031 13.1 0.0 1.4 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 PIK46654.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family YfkD PF14167.6 PIK46655.1 - 0.03 13.5 0.1 0.052 12.7 0.1 1.4 1 0 0 1 1 1 0 YfkD-like protein CdvA PF18822.1 PIK46656.1 - 0.038 13.8 3.5 1.9 8.4 0.2 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain PAS_6 PF08348.11 PIK46656.1 - 0.057 13.3 0.8 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 YheO-like PAS domain RVT_1 PF00078.27 PIK46657.1 - 6.1e-12 45.5 0.1 7.8e-12 45.2 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Smoothelin PF12510.8 PIK46659.1 - 3.3e-15 55.9 9.2 7.1e-15 54.8 9.2 1.6 1 0 0 1 1 1 1 Smoothelin cytoskeleton protein Integrase_H2C2 PF17921.1 PIK46661.1 - 0.093 12.9 0.6 0.093 12.9 0.6 1.9 2 0 0 2 2 2 0 Integrase zinc binding domain Peptidase_A17 PF05380.13 PIK46662.1 - 1.3e-41 142.3 0.1 1.5e-41 142.1 0.1 1.0 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK46663.1 - 2.2e-07 31.0 0.9 3.1e-07 30.4 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK46663.1 - 0.074 13.6 0.5 0.42 11.2 0.1 2.3 2 0 0 2 2 2 0 Tis11B like protein, N terminus NUDE_C PF04880.13 PIK46663.1 - 2.8 8.4 9.1 0.8 10.2 5.3 2.1 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region DUF753 PF05444.12 PIK46663.1 - 8 6.4 8.2 1.5 8.8 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF753) adh_short PF00106.25 PIK46665.1 - 8.6e-25 87.3 0.0 1.6e-24 86.4 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK46665.1 - 9e-19 67.9 0.0 1.1e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK46665.1 - 1.4e-06 28.4 0.1 2e-06 27.9 0.1 1.3 1 1 0 1 1 1 1 KR domain LptE PF04390.12 PIK46665.1 - 0.045 14.4 0.0 0.13 13.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide-assembly Glyco_transf_8 PF01501.20 PIK46666.1 - 2.3e-21 76.5 0.0 4.8e-12 46.0 0.0 2.2 1 1 1 2 2 2 2 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 PIK46666.1 - 0.019 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.8 PIK46666.1 - 0.028 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative QRPTase_C PF01729.19 PIK46667.1 - 2.2e-44 151.2 0.1 2.7e-44 150.9 0.1 1.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Pantoate_transf PF02548.15 PIK46667.1 - 0.02 14.3 0.1 0.025 14.0 0.1 1.1 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase QRPTase_N PF02749.16 PIK46668.1 - 3.1e-09 36.8 0.0 6.7e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain FLYWCH PF04500.16 PIK46668.1 - 1.8e-05 24.8 0.2 9.2e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 FLYWCH zinc finger domain HTH_23 PF13384.6 PIK46670.1 - 0.003 17.3 0.2 0.74 9.7 0.0 3.1 3 0 0 3 3 3 2 Homeodomain-like domain DUF2635 PF10948.8 PIK46670.1 - 0.033 13.9 0.0 0.18 11.5 0.0 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) HTH_29 PF13551.6 PIK46670.1 - 0.35 10.9 11.8 3.9 7.6 0.0 4.8 5 0 0 5 5 5 0 Winged helix-turn helix SUIM_assoc PF16619.5 PIK46671.1 - 0.014 15.5 0.7 0.014 15.5 0.7 3.5 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2635 PF10948.8 PIK46671.1 - 0.057 13.1 0.0 0.2 11.4 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) Sugar_tr PF00083.24 PIK46672.1 - 6.3e-38 130.8 33.0 1.3e-37 129.8 33.0 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK46672.1 - 3.2e-31 108.5 45.6 1.7e-21 76.6 25.4 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF2208 PF09973.9 PIK46672.1 - 0.021 14.4 0.2 0.021 14.4 0.2 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2208) SBDS_C PF09377.10 PIK46673.1 - 1.7e-36 124.7 4.8 1.8e-36 124.6 1.7 2.0 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 PIK46673.1 - 4e-33 113.3 1.9 6.6e-33 112.6 1.9 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SUV3_C PF12513.8 PIK46673.1 - 0.17 11.8 0.0 0.48 10.4 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal Myb_DNA-binding PF00249.31 PIK46676.1 - 3.2e-10 40.0 0.5 5.1e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK46676.1 - 0.00028 21.1 3.9 0.11 12.8 0.1 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Phosducin PF02114.16 PIK46676.1 - 0.015 14.3 1.6 0.032 13.2 1.6 1.5 1 0 0 1 1 1 0 Phosducin Myb_DNA-bind_7 PF15963.5 PIK46676.1 - 0.7 9.8 9.3 0.22 11.5 6.1 1.9 2 0 0 2 2 2 0 Myb DNA-binding like GPS2_interact PF15784.5 PIK46677.1 - 9.6e-24 83.6 6.9 9.6e-24 83.6 6.9 3.0 4 1 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain UNC-79 PF14776.6 PIK46677.1 - 0.0028 16.5 1.4 0.0038 16.1 1.4 1.2 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 ATG_C PF09333.11 PIK46677.1 - 0.059 13.7 0.1 0.2 12.0 0.1 1.9 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain DivIC PF04977.15 PIK46677.1 - 0.15 11.8 5.7 0.51 10.2 3.8 2.7 2 0 0 2 2 2 0 Septum formation initiator SR-25 PF10500.9 PIK46678.1 - 4.4e-36 124.6 30.2 4.4e-36 124.6 30.2 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein DUF4538 PF15061.6 PIK46678.1 - 0.041 13.6 0.1 0.14 11.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) CDC45 PF02724.14 PIK46678.1 - 1.6 6.9 24.3 1.8 6.8 24.3 1.2 1 0 0 1 1 1 0 CDC45-like protein AF-4 PF05110.13 PIK46678.1 - 2.3 6.2 27.1 2.4 6.1 27.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4775 PF16001.5 PIK46678.1 - 2.7 7.3 29.4 3.1 7.1 29.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) NPR3 PF03666.13 PIK46678.1 - 4.2 6.1 20.8 4.9 5.8 20.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BTK PF00779.19 PIK46680.1 - 0.23 11.3 2.0 0.48 10.3 2.0 1.5 1 0 0 1 1 1 0 BTK motif VWD PF00094.25 PIK46682.1 - 4.7e-50 169.9 1.5 8.3e-26 91.1 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 PIK46682.1 - 8.5e-29 99.8 21.8 5.6e-16 58.7 1.4 4.3 3 0 0 3 3 3 2 C8 domain Lectin_C PF00059.21 PIK46682.1 - 5.1e-17 62.6 0.2 4.8e-08 33.7 0.0 3.1 2 0 0 2 2 2 2 Lectin C-type domain Methyltransf_FA PF12248.8 PIK46682.1 - 2.4e-12 47.1 0.0 8.2e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Farnesoic acid 0-methyl transferase TILa PF12714.7 PIK46682.1 - 1.8e-08 34.2 6.6 1.8e-08 34.2 6.6 4.0 3 1 1 4 4 4 1 TILa domain TIL PF01826.17 PIK46682.1 - 6.7e-08 32.7 9.5 6.7e-08 32.7 9.5 4.7 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain RGM_N PF06535.12 PIK46682.1 - 0.0015 18.7 9.7 0.13 12.4 1.9 3.5 4 0 0 4 4 4 2 Repulsive guidance molecule (RGM) N-terminus EGF_3 PF12947.7 PIK46682.1 - 2.6 8.3 25.3 0.058 13.6 8.1 3.6 3 0 0 3 3 3 0 EGF domain EGF_MSP1_1 PF12946.7 PIK46682.1 - 6.1 7.0 12.8 1.3 9.1 6.1 3.2 2 0 0 2 2 2 0 MSP1 EGF domain 1 Pax7 PF12360.8 PIK46683.1 - 0.075 13.2 4.5 5.1 7.4 0.4 2.4 2 0 0 2 2 2 0 Paired box protein 7 HYR PF02494.16 PIK46685.1 - 1.4e-09 38.1 0.1 2.8e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 HYR domain TILa PF12714.7 PIK46685.1 - 6.4e-09 35.6 11.5 1.9e-08 34.1 11.5 1.9 1 0 0 1 1 1 1 TILa domain Lectin_C PF00059.21 PIK46685.1 - 0.00014 22.5 3.5 0.00014 22.5 3.5 2.1 1 1 0 1 1 1 1 Lectin C-type domain TPH PF13868.6 PIK46686.1 - 7.3e-10 37.9 59.3 7.3e-10 37.9 59.3 4.3 4 0 0 4 4 4 3 Trichohyalin-plectin-homology domain VWD PF00094.25 PIK46687.1 - 2.6e-56 190.3 0.0 2.6e-30 105.8 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type D domain TILa PF12714.7 PIK46687.1 - 5.8e-27 93.4 119.4 3.5e-10 39.7 9.3 9.0 8 1 1 9 9 9 4 TILa domain TIL PF01826.17 PIK46687.1 - 1.5e-24 86.0 72.6 1.7e-11 44.2 19.1 11.6 8 4 2 10 10 10 3 Trypsin Inhibitor like cysteine rich domain C8 PF08742.11 PIK46687.1 - 1.5e-17 63.8 15.1 3.2e-10 40.3 4.0 6.8 8 0 0 8 8 8 2 C8 domain Methyltransf_FA PF12248.8 PIK46687.1 - 2.4e-14 53.5 0.0 4.1e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase HYR PF02494.16 PIK46687.1 - 1.4e-12 47.8 0.0 3.8e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 HYR domain Lectin_C PF00059.21 PIK46687.1 - 8.3e-10 39.4 0.2 0.00028 21.6 0.0 3.5 3 0 0 3 3 3 2 Lectin C-type domain EGF_3 PF12947.7 PIK46687.1 - 1.2e-07 31.8 41.6 9.5e-05 22.5 10.3 10.2 10 0 0 10 10 10 4 EGF domain EGF_MSP1_1 PF12946.7 PIK46687.1 - 0.00059 19.8 23.2 0.00072 19.6 6.5 9.4 10 0 0 10 10 10 4 MSP1 EGF domain 1 VWD PF00094.25 PIK46688.1 - 1e-32 113.6 0.6 1.5e-32 113.1 0.6 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK46688.1 - 2.7e-11 43.7 0.3 2.7e-11 43.7 0.3 2.6 2 0 0 2 2 2 1 C8 domain TIL PF01826.17 PIK46688.1 - 4.9e-11 42.7 16.4 4.9e-11 42.7 16.4 3.7 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK46688.1 - 2e-08 34.0 11.5 2e-08 34.0 11.5 3.1 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK46688.1 - 0.017 15.3 12.1 0.017 15.3 12.1 3.4 3 0 0 3 3 3 0 EGF domain DUF1521 PF07481.11 PIK46688.1 - 0.13 12.3 0.1 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1521) EGF_MSP1_1 PF12946.7 PIK46688.1 - 1.7 8.8 17.2 0.16 12.1 9.2 3.1 3 0 0 3 3 3 0 MSP1 EGF domain 1 Glyco_transf_10 PF00852.19 PIK46689.1 - 5.7e-42 143.4 2.5 9.5e-42 142.7 2.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK46689.1 - 1.3e-07 32.0 0.6 5.2e-07 30.1 0.2 2.2 1 1 1 2 2 2 1 Fucosyltransferase, N-terminal Tmemb_9 PF05434.11 PIK46689.1 - 0.11 12.4 0.3 0.21 11.4 0.3 1.4 1 0 0 1 1 1 0 TMEM9 COesterase PF00135.28 PIK46690.1 - 0.017 14.1 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Carboxylesterase family RVT_1 PF00078.27 PIK46691.1 - 2.6e-41 141.6 0.9 3.8e-41 141.0 0.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_4 PF02056.16 PIK46692.1 - 0.11 12.0 0.2 0.23 11.0 0.2 1.5 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Barstar PF01337.18 PIK46692.1 - 0.11 12.5 0.1 0.48 10.5 0.1 2.1 1 1 1 2 2 2 0 Barstar (barnase inhibitor) Pkinase_Tyr PF07714.17 PIK46693.1 - 1.5e-23 83.4 0.0 3.9e-13 49.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK46693.1 - 4.2e-07 29.6 0.0 8.9e-07 28.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain McyA_C PF12593.8 PIK46693.1 - 0.0038 17.0 0.0 0.008 15.9 0.0 1.5 1 0 0 1 1 1 1 Microcystin synthetase C terminal KN17_SH3 PF18131.1 PIK46693.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 KN17 SH3-like C-terminal domain Pkinase_Tyr PF07714.17 PIK46694.1 - 2.4e-41 141.7 0.0 3e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46694.1 - 2.3e-16 59.9 0.0 3.8e-16 59.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK46694.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like zf-CCHC PF00098.23 PIK46695.1 - 9.1e-07 28.7 2.4 1.6e-06 27.9 2.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK46695.1 - 0.037 13.8 0.3 0.07 12.9 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46695.1 - 7.2 6.7 7.2 1.1 9.3 3.1 1.8 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 PIK46696.1 - 5e-16 59.0 0.0 9e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK46696.1 - 2.8e-12 46.6 0.1 4.3e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK46697.1 - 4.7e-37 126.0 0.0 8.6e-37 125.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46697.1 - 8.4e-36 122.4 0.0 1.2e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MATalpha_HMGbox PF04769.12 PIK46697.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Ig_3 PF13927.6 PIK46698.1 - 1.3e-06 28.9 8.1 0.13 12.9 0.3 4.2 3 2 1 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK46698.1 - 1.9e-05 24.6 0.5 0.062 13.4 0.0 4.0 3 2 0 3 3 3 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK46698.1 - 2.5e-05 24.5 7.7 0.19 12.1 0.2 4.1 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK46698.1 - 0.003 17.7 1.3 0.017 15.3 0.0 2.8 4 1 0 4 4 4 1 Immunoglobulin V-set domain Adeno_E3_CR1 PF02440.15 PIK46698.1 - 0.042 13.6 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 ig PF00047.25 PIK46698.1 - 0.12 12.6 5.5 5.6 7.2 0.0 3.8 4 1 0 4 4 4 0 Immunoglobulin domain RVT_1 PF00078.27 PIK46699.1 - 4.9e-11 42.6 0.0 6.9e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HBS1_N PF08938.10 PIK46699.1 - 0.026 14.8 0.0 0.058 13.7 0.0 1.6 1 0 0 1 1 1 0 HBS1 N-terminus IRF PF00605.17 PIK46699.1 - 0.041 14.2 1.3 0.49 10.7 0.3 2.4 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor Inhibitor_I36 PF03995.13 PIK46699.1 - 0.17 11.9 0.6 0.38 10.7 0.1 1.8 2 0 0 2 2 2 0 Peptidase inhibitor family I36 W2 PF02020.18 PIK46699.1 - 0.19 11.9 1.2 0.29 11.3 0.1 1.8 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon Pkinase_Tyr PF07714.17 PIK46700.1 - 1e-45 156.0 0.0 1.5e-45 155.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46700.1 - 5.8e-18 65.2 0.0 1.1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RIFIN PF02009.16 PIK46700.1 - 3.7e-06 27.0 0.8 6.7e-06 26.2 0.8 1.4 1 0 0 1 1 1 1 Rifin TMEM154 PF15102.6 PIK46700.1 - 0.00038 20.4 0.3 0.00079 19.4 0.3 1.5 1 0 0 1 1 1 1 TMEM154 protein family Ig_2 PF13895.6 PIK46700.1 - 0.0032 17.8 1.5 0.0058 16.9 0.4 2.0 2 0 0 2 2 2 1 Immunoglobulin domain DUF4834 PF16118.5 PIK46700.1 - 0.012 16.6 0.0 0.039 14.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MGC-24 PF05283.11 PIK46700.1 - 0.017 15.6 4.5 0.017 15.6 4.5 1.7 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Orf78 PF06024.12 PIK46700.1 - 0.044 14.1 2.4 0.047 14.0 0.2 2.1 1 1 1 2 2 2 0 Orf78 (ac78) ECSCR PF15820.5 PIK46700.1 - 0.081 12.8 0.1 0.87 9.4 0.0 2.3 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Mucin PF01456.17 PIK46700.1 - 0.46 10.5 14.3 0.82 9.6 14.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Syndecan PF01034.20 PIK46700.1 - 0.49 10.3 1.8 1 9.3 1.8 1.5 1 0 0 1 1 1 0 Syndecan domain Pkinase_Tyr PF07714.17 PIK46701.1 - 1.6e-38 132.5 0.0 2.2e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK46701.1 - 3.8e-18 65.8 0.0 5.9e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK46701.1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Exo_endo_phos_2 PF14529.6 PIK46702.1 - 1.2e-13 50.9 0.1 1.9e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK46702.1 - 1.9e-06 27.6 0.0 2.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK46703.1 - 2.5e-08 33.7 0.1 8e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) ODV-E18 PF10717.9 PIK46704.1 - 0.0078 16.1 0.2 0.012 15.5 0.0 1.4 2 0 0 2 2 2 1 Occlusion-derived virus envelope protein ODV-E18 DUF2615 PF11027.8 PIK46704.1 - 0.03 14.4 0.3 0.12 12.6 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) DUF4330 PF14221.6 PIK46704.1 - 0.034 14.4 0.0 0.039 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) SARAF PF06682.12 PIK46704.1 - 0.055 13.1 0.0 0.065 12.9 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 PIK46704.1 - 0.13 13.1 0.0 0.16 12.8 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SCIMP PF15050.6 PIK46704.1 - 7.6 7.0 5.5 18 5.8 0.1 2.1 1 1 1 2 2 2 0 SCIMP protein SAM_1 PF00536.30 PIK46705.1 - 6.3e-14 52.2 0.0 9e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK46705.1 - 1.2e-09 38.1 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHC2_SAM_assoc PF16616.5 PIK46705.1 - 3e-05 24.8 1.4 6.5e-05 23.7 1.4 1.6 1 1 0 1 1 1 1 Unstructured region on Polyhomeotic-like protein 1 and 2 SAM_PNT PF02198.16 PIK46705.1 - 0.00023 21.1 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-C6H2 PF15801.5 PIK46705.1 - 0.053 13.8 0.9 0.11 12.8 0.9 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-CGNR PF11706.8 PIK46705.1 - 0.15 11.9 3.7 0.3 11.0 3.7 1.5 1 0 0 1 1 1 0 CGNR zinc finger zf-FCS PF06467.14 PIK46705.1 - 0.2 11.6 3.9 5.8 6.9 3.9 2.4 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif RBR PF17208.3 PIK46706.1 - 0.001 19.7 3.5 0.001 19.7 3.5 4.6 3 1 0 3 3 3 1 RNA binding Region CDC48_2 PF02933.17 PIK46706.1 - 0.23 11.3 5.1 0.52 10.1 0.2 3.7 5 0 0 5 5 5 0 Cell division protein 48 (CDC48), domain 2 RIBIOP_C PF04950.12 PIK46707.1 - 9.6e-89 297.7 2.1 1.6e-88 296.9 0.0 2.4 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 PIK46707.1 - 1.1e-32 111.9 0.0 6e-32 109.6 0.0 2.4 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 PIK46707.1 - 1.7e-06 27.7 1.6 0.00019 21.0 0.0 3.3 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 PIK46707.1 - 0.0018 18.5 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK46707.1 - 0.0024 18.3 0.3 0.0068 16.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 PIK46707.1 - 0.014 15.5 0.2 0.077 13.1 0.2 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK46707.1 - 0.037 14.4 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 PIK46707.1 - 0.044 13.9 0.0 0.18 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain Antistasin PF02822.14 PIK46708.1 - 6.7e-67 221.7 149.6 2.4e-09 37.6 9.8 9.6 9 1 0 9 9 9 8 Antistasin family Antistasin PF02822.14 PIK46709.1 - 2e-150 488.8 502.0 2.6e-09 37.5 11.8 28.3 29 3 0 29 29 29 22 Antistasin family WAP PF00095.21 PIK46709.1 - 5.2e-80 263.6 210.6 5.3e-12 45.9 15.2 19.4 15 3 1 16 16 16 10 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 PIK46710.1 - 5.3e-83 273.2 239.1 2e-11 44.1 11.9 11.7 13 0 0 13 13 13 9 WAP-type (Whey Acidic Protein) 'four-disulfide core' Antistasin PF02822.14 PIK46710.1 - 3.8e-14 53.0 57.9 6.6e-08 33.1 8.9 12.1 14 3 0 14 14 14 4 Antistasin family Kelch_1 PF01344.25 PIK46711.1 - 9.7e-73 239.6 13.5 1.4e-15 56.5 0.5 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK46711.1 - 6.9e-43 143.6 4.0 8.8e-08 32.2 0.1 6.3 2 1 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 PIK46711.1 - 1e-26 91.8 4.7 4.3e-05 23.3 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 PIK46711.1 - 1.1e-23 83.0 14.0 0.0001 22.5 0.0 6.5 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK46711.1 - 5.3e-19 68.0 7.6 4.8e-05 23.3 0.2 6.3 4 2 2 6 6 6 4 Galactose oxidase, central domain BACK PF07707.15 PIK46711.1 - 7.9e-13 48.4 0.1 1.3e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 PIK46711.1 - 1.3e-12 47.4 8.7 0.0053 16.7 0.4 5.5 5 0 0 5 5 5 4 Kelch motif BTB PF00651.31 PIK46712.1 - 2.4e-32 111.5 1.6 3.2e-32 111.1 1.6 1.2 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK46712.1 - 0.0076 16.3 0.1 0.04 14.0 0.0 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch Sulfotransfer_3 PF13469.6 PIK46713.1 - 4.5e-06 27.2 0.0 6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family 2-oxogl_dehyd_N PF16078.5 PIK46713.1 - 0.17 11.5 3.6 0.75 9.4 0.4 2.4 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus YEATS PF03366.16 PIK46715.1 - 7.1e-33 112.4 1.8 1.5e-32 111.4 1.8 1.5 1 0 0 1 1 1 1 YEATS family DUF1664 PF07889.12 PIK46715.1 - 0.14 12.2 0.9 0.25 11.4 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.15 PIK46715.1 - 0.39 10.5 2.3 0.82 9.5 2.3 1.5 1 0 0 1 1 1 0 Septum formation initiator Swi5 PF07061.11 PIK46715.1 - 2.8 8.1 5.0 0.84 9.8 2.0 1.6 2 0 0 2 2 2 0 Swi5 Peptidase_M13_N PF05649.13 PIK46716.1 - 1.2e-23 84.4 0.1 1.4e-23 84.2 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK46717.1 - 3.6e-14 52.9 0.9 1.3e-13 51.0 0.2 2.1 2 1 0 2 2 2 1 Peptidase family M13 Peptidase_M13_N PF05649.13 PIK46717.1 - 1.3e-08 35.0 0.2 2.7e-08 33.9 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M13 Neur_chan_LBD PF02931.23 PIK46718.1 - 8.9e-27 93.9 5.2 9.5e-27 93.8 5.2 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain V-set PF07686.17 PIK46719.1 - 1.3e-07 31.7 0.2 1.2e-05 25.5 0.1 2.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK46719.1 - 9.6e-07 29.3 0.2 0.017 15.7 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK46719.1 - 4.8e-06 26.5 0.0 0.0042 17.1 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK46719.1 - 2.4e-05 24.4 0.1 0.034 14.3 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK46719.1 - 0.00019 21.7 1.6 0.064 13.6 0.0 2.9 3 1 0 3 3 3 2 Immunoglobulin domain ICAM_N PF03921.14 PIK46719.1 - 0.0015 18.2 2.0 0.47 10.2 0.1 2.4 1 1 1 2 2 2 2 Intercellular adhesion molecule (ICAM), N-terminal domain Death PF00531.22 PIK46720.1 - 4.3e-15 55.6 0.9 6.1e-15 55.2 0.9 1.2 1 0 0 1 1 1 1 Death domain RNA_pol_Rpb2_3 PF04565.16 PIK46721.1 - 1.3e-21 76.6 0.0 2e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 PIK46721.1 - 2.8e-06 27.1 0.0 7.9e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.15 PIK46721.1 - 0.01 15.3 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase beta subunit RNA_pol_Rpb2_6 PF00562.28 PIK46722.1 - 7.7e-52 176.7 0.1 3.7e-51 174.4 0.1 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 SCAN PF02023.17 PIK46722.1 - 4.9e-13 48.7 0.0 1.2e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 SCAN domain RNA_pol_Rpb2_5 PF04567.17 PIK46722.1 - 7.6e-11 42.4 2.8 7.2e-10 39.3 2.8 2.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Integrase_H2C2 PF17921.1 PIK46722.1 - 2.8e-10 40.1 0.0 8.3e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK46722.1 - 3.2e-06 27.0 2.0 6.4e-06 26.0 2.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46722.1 - 0.0053 16.6 1.4 0.012 15.4 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle DUF4407 PF14362.6 PIK46722.1 - 0.43 9.9 6.0 1.2 8.5 6.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.27 PIK46723.1 - 3.9e-08 33.1 0.0 7.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 PIK46723.1 - 0.083 13.2 0.3 0.26 11.6 0.1 1.9 2 0 0 2 2 2 0 PRANC domain Glyco_transf_11 PF01531.16 PIK46723.1 - 0.084 12.1 0.1 0.18 11.0 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 11 RNA_pol_Rpb2_7 PF04560.20 PIK46724.1 - 3.4e-32 110.7 0.1 6.8e-32 109.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_6 PF00562.28 PIK46724.1 - 0.0039 16.3 0.0 0.0056 15.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 TIP120 PF08623.10 PIK46725.1 - 0.22 11.3 1.3 0.51 10.1 0.1 2.0 2 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) rve PF00665.26 PIK46726.1 - 3.7e-15 56.2 0.0 4.8e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46726.1 - 5.5e-14 52.0 0.7 1.3e-13 50.9 0.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46726.1 - 0.0029 17.3 0.0 0.0065 16.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.6 PIK46727.1 - 1.6e-09 38.2 0.0 9.7e-09 35.7 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK46727.1 - 5.9e-08 33.2 0.1 1.5e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 PIK46727.1 - 0.0029 17.4 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal RVP PF00077.20 PIK46727.1 - 0.0049 17.1 0.1 0.024 14.9 0.1 2.1 1 1 0 1 1 1 1 Retroviral aspartyl protease EGF PF00008.27 PIK46728.1 - 3.2e-05 24.1 5.7 5.3e-05 23.4 5.7 1.4 1 0 0 1 1 1 1 EGF-like domain SEA PF01390.20 PIK46728.1 - 0.0018 18.3 0.2 0.0032 17.5 0.2 1.4 1 1 0 1 1 1 1 SEA domain hEGF PF12661.7 PIK46728.1 - 0.012 16.2 3.0 0.047 14.3 3.0 2.1 1 1 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK46728.1 - 0.044 14.1 8.0 0.092 13.1 8.0 1.5 1 0 0 1 1 1 0 EGF-like domain FXa_inhibition PF14670.6 PIK46728.1 - 0.89 9.9 6.3 2 8.8 6.3 1.6 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK46729.1 - 6.4e-100 327.1 256.9 2e-10 40.7 4.6 19.0 17 2 2 19 19 19 15 Calcium-binding EGF domain cEGF PF12662.7 PIK46729.1 - 1.4e-55 184.8 172.1 2.3e-10 40.2 1.3 19.6 19 0 0 19 19 19 14 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK46729.1 - 1.1e-39 134.3 222.3 5.6e-09 36.0 8.4 18.6 18 1 0 18 18 18 13 EGF domain hEGF PF12661.7 PIK46729.1 - 2.3e-20 72.4 184.3 0.0049 17.4 2.7 21.3 22 0 0 22 22 22 13 Human growth factor-like EGF EGF PF00008.27 PIK46729.1 - 2.8e-20 72.3 253.9 0.00024 21.3 9.1 21.4 20 2 0 20 20 20 12 EGF-like domain FXa_inhibition PF14670.6 PIK46729.1 - 7.7e-13 48.5 241.3 8.6e-07 29.1 6.0 18.9 15 4 3 18 18 18 13 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 PIK46729.1 - 1.7e-10 41.0 151.4 0.0011 19.3 1.1 15.6 15 1 1 16 16 16 10 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 PIK46729.1 - 3.2e-10 39.9 179.0 9.8e-05 22.3 4.7 16.8 17 0 0 17 17 17 11 MSP1 EGF domain 1 NIDO PF06119.14 PIK46730.1 - 1e-08 36.0 0.0 2e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Nidogen-like AMOP PF03782.17 PIK46730.1 - 0.025 14.7 2.7 0.038 14.1 2.7 1.3 1 0 0 1 1 1 0 AMOP domain DUF764 PF05561.11 PIK46730.1 - 0.11 12.2 0.3 0.21 11.4 0.3 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) Chromosome_seg PF13889.6 PIK46731.1 - 2.8e-20 72.2 0.7 8.1e-20 70.7 0.7 1.9 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 PIK46731.1 - 4.6e-14 52.8 0.1 1.2e-13 51.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) RhlB PF12300.8 PIK46731.1 - 0.043 14.0 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB DUF1797 PF08796.10 PIK46731.1 - 0.18 11.9 0.3 0.4 10.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) DnaJ_C PF01556.18 PIK46732.1 - 1.1e-39 135.9 0.6 1.5e-39 135.4 0.6 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 PIK46732.1 - 2.2e-25 88.6 2.7 4.5e-25 87.5 2.7 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 PIK46732.1 - 7e-15 55.1 17.2 1.2e-14 54.4 17.2 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF2614 PF11023.8 PIK46732.1 - 1.7 8.7 6.2 6.1 7.0 0.8 2.3 1 1 1 2 2 2 0 Zinc-ribbon containing domain HypA PF01155.19 PIK46732.1 - 2.7 8.0 10.5 11 6.1 3.0 2.5 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA A2L_zn_ribbon PF08792.10 PIK46732.1 - 4 7.3 10.7 4.7 7.1 0.1 3.7 3 1 1 4 4 4 0 A2L zinc ribbon domain DZR PF12773.7 PIK46732.1 - 4.3 7.5 6.8 13 6.0 1.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon Cytochrome_C7 PF14522.6 PIK46732.1 - 8.8 6.4 9.0 1.5e+02 2.5 9.0 2.5 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c TRAM_LAG1_CLN8 PF03798.16 PIK46733.1 - 1.1e-31 110.2 18.5 1.3e-31 109.9 18.5 1.1 1 0 0 1 1 1 1 TLC domain Kinesin PF00225.23 PIK46734.1 - 1.2e-98 330.1 0.0 2.3e-98 329.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK46734.1 - 1.6e-19 70.4 0.0 7e-19 68.2 0.0 2.2 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 PIK46734.1 - 1.9e-07 31.4 0.7 1.9e-07 31.4 0.7 2.7 2 0 0 2 2 2 1 Kinesin protein 1B Kinesin_assoc PF16183.5 PIK46734.1 - 2.1e-07 31.3 2.1 2.1e-07 31.3 2.1 3.9 3 1 1 4 4 4 2 Kinesin-associated FHA PF00498.26 PIK46734.1 - 1.5e-06 28.4 0.0 3.6e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK46734.1 - 4.1e-06 27.0 0.0 1.6e-05 25.1 0.0 2.0 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain EF-hand_6 PF13405.6 PIK46735.1 - 1.6e-05 24.5 0.7 0.007 16.2 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK46735.1 - 0.0006 19.2 3.3 0.027 14.0 0.2 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 PIK46735.1 - 0.00091 19.6 0.9 0.048 14.1 0.1 2.8 2 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK46735.1 - 0.0018 18.1 1.1 2.2 8.2 0.1 3.4 3 0 0 3 3 3 1 EF-hand domain pair zf-RRPl_C4 PF17026.5 PIK46735.1 - 0.0051 16.9 0.4 0.011 15.9 0.2 1.6 2 1 0 2 2 2 1 Putative ribonucleoprotein zinc-finger pf C4 type EF-hand_9 PF14658.6 PIK46735.1 - 0.066 13.5 0.1 0.23 11.8 0.0 1.9 3 0 0 3 3 3 0 EF-hand domain Laminin_G_2 PF02210.24 PIK46736.1 - 4.7e-71 237.3 9.1 4.7e-22 78.9 0.3 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 PIK46736.1 - 3.2e-48 163.3 1.8 8.8e-17 61.5 0.1 4.4 4 0 0 4 4 4 4 Laminin G domain Laminin_G_3 PF13385.6 PIK46736.1 - 1.7e-19 70.4 2.6 2e-06 28.1 0.1 4.5 4 0 0 4 4 4 3 Concanavalin A-like lectin/glucanases superfamily F5_F8_type_C PF00754.25 PIK46736.1 - 6.6e-13 48.9 1.7 2.8e-12 46.9 0.5 2.7 3 0 0 3 3 3 1 F5/8 type C domain EGF PF00008.27 PIK46736.1 - 3.4e-05 24.1 32.4 6.5e-05 23.1 10.3 3.1 3 0 0 3 3 3 2 EGF-like domain Sigma_reg_N PF13800.6 PIK46736.1 - 0.061 13.6 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TPR_12 PF13424.6 PIK46737.1 - 1.2e-13 51.1 3.3 5e-05 23.5 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK46737.1 - 0.0038 17.0 1.7 0.63 10.0 0.1 3.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK46737.1 - 0.026 15.0 1.5 0.18 12.3 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46737.1 - 0.034 14.4 4.8 1.4 9.3 0.1 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK46737.1 - 0.11 13.2 4.5 19 6.2 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK46737.1 - 0.4 10.9 5.8 7.1 7.0 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Bax1-I PF01027.20 PIK46739.1 - 1.1e-23 84.2 13.5 1.1e-23 84.1 13.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 PIK46739.1 - 0.007 16.0 11.2 0.01 15.4 11.2 1.2 1 0 0 1 1 1 1 Bax inhibitor 1 like TSP_1 PF00090.19 PIK46740.1 - 1.5e-05 25.1 10.3 2.7e-05 24.3 10.3 1.4 1 0 0 1 1 1 1 Thrombospondin type 1 domain hEGF PF12661.7 PIK46741.1 - 2.2e-06 28.1 88.7 0.0017 18.9 8.4 8.7 8 0 0 8 8 8 5 Human growth factor-like EGF TSP_1 PF00090.19 PIK46741.1 - 2.8e-05 24.2 21.0 0.00038 20.6 6.6 4.9 6 1 1 7 7 7 2 Thrombospondin type 1 domain EGF_2 PF07974.13 PIK46741.1 - 7.4e-05 23.0 29.1 0.0012 19.1 10.4 8.1 8 0 0 8 8 8 4 EGF-like domain EGF PF00008.27 PIK46741.1 - 0.0022 18.3 9.1 0.0022 18.3 9.1 7.7 7 1 0 7 7 7 5 EGF-like domain Glyco_tran_28_C PF04101.16 PIK46742.1 - 1.6e-30 106.3 0.0 1.7e-30 106.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Dala_Dala_lig_N PF01820.21 PIK46742.1 - 0.036 14.5 0.0 0.12 12.9 0.0 1.8 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus Csm1_N PF18504.1 PIK46742.1 - 0.043 14.2 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain RE_HindVP PF09519.10 PIK46742.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 HindVP restriction endonuclease Mito_carr PF00153.27 PIK46743.1 - 2.1e-39 133.3 0.1 3.2e-20 71.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LapA_dom PF06305.11 PIK46743.1 - 0.084 12.7 0.1 6.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain ASFV_L11L PF05293.11 PIK46743.1 - 0.11 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 African swine fever virus (ASFV) L11L protein 7tm_1 PF00001.21 PIK46744.1 - 4.5e-23 81.9 11.7 5.4e-23 81.7 11.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK46744.1 - 8.3e-06 25.3 3.8 0.0023 17.3 1.5 2.0 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw DUF2298 PF10060.9 PIK46744.1 - 0.00016 20.6 2.7 0.00021 20.2 2.7 1.1 1 0 0 1 1 1 1 Uncharacterized membrane protein (DUF2298) 7TM_GPCR_Srx PF10328.9 PIK46744.1 - 0.0016 18.1 8.1 0.0027 17.4 8.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx E1-E2_ATPase PF00122.20 PIK46744.1 - 0.0072 15.9 0.9 0.0072 15.9 0.9 1.6 2 0 0 2 2 2 1 E1-E2 ATPase TctB PF07331.11 PIK46744.1 - 0.0091 16.3 7.9 0.074 13.3 6.8 2.1 1 1 1 2 2 2 1 Tripartite tricarboxylate transporter TctB family Voltage_CLC PF00654.20 PIK46744.1 - 0.017 14.4 2.8 0.022 14.0 2.8 1.2 1 0 0 1 1 1 0 Voltage gated chloride channel CobD_Cbib PF03186.13 PIK46744.1 - 0.024 13.8 0.2 0.035 13.3 0.2 1.3 1 0 0 1 1 1 0 CobD/Cbib protein DUF2207 PF09972.9 PIK46744.1 - 0.2 10.4 3.2 4.5 5.9 0.0 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4131 PF13567.6 PIK46744.1 - 0.22 11.2 6.7 1 9.0 2.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Glucan_synthase PF02364.15 PIK46744.1 - 0.34 9.0 1.9 0.47 8.6 0.3 1.7 1 1 1 2 2 2 0 1,3-beta-glucan synthase component PIG-F PF06699.11 PIK46744.1 - 0.37 10.9 5.7 5.2 7.2 0.7 2.1 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F PMT_4TMC PF16192.5 PIK46744.1 - 0.49 10.0 6.1 0.5 9.9 1.0 2.2 1 1 1 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase PRA1 PF03208.19 PIK46744.1 - 1.9 8.1 13.0 1.2 8.8 3.9 2.2 2 0 0 2 2 2 0 PRA1 family protein DUF2391 PF09622.10 PIK46744.1 - 6.8 5.9 6.6 1.6 8.0 0.5 2.5 2 1 2 4 4 4 0 Putative integral membrane protein (DUF2391) ketoacyl-synt PF00109.26 PIK46745.1 - 2.4e-83 279.6 0.0 4e-83 278.9 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 PIK46745.1 - 6.1e-37 126.3 0.3 1.2e-36 125.3 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 PIK46745.1 - 2.1e-18 66.9 0.0 2.2e-13 50.4 0.0 2.3 2 0 0 2 2 2 2 Acyl transferase domain KAsynt_C_assoc PF16197.5 PIK46745.1 - 6.3e-15 55.6 0.0 1.4e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 PIK46745.1 - 9e-07 28.5 0.1 1.8e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 PIK46745.1 - 0.021 14.7 1.2 0.05 13.5 0.4 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PDZ PF00595.24 PIK46746.1 - 3.9e-28 97.6 4.3 2.2e-15 56.8 0.3 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK46746.1 - 8.7e-13 47.9 0.3 2.2e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK46746.1 - 9.3e-09 35.5 0.4 0.00057 20.1 0.1 2.3 2 0 0 2 2 2 2 PDZ domain ubiquitin PF00240.23 PIK46747.1 - 1.1e-45 153.2 0.3 1.7e-22 78.9 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK46747.1 - 6e-13 48.4 0.4 2.2e-05 24.2 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK46747.1 - 4.2e-06 27.1 0.5 0.14 12.7 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK46747.1 - 0.0024 17.8 0.1 1.9 8.4 0.0 2.8 2 1 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Big_7 PF17957.1 PIK46747.1 - 0.0043 17.8 0.1 1.5 9.6 0.0 2.3 2 0 0 2 2 2 2 Bacterial Ig domain Ubiquitin_5 PF18037.1 PIK46747.1 - 0.0096 16.3 0.1 4.6 7.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK46747.1 - 0.032 14.4 0.0 4.6 7.4 0.0 2.7 2 2 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF3978 PF13123.6 PIK46747.1 - 0.052 13.3 0.1 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3978) Ubiquitin_4 PF18036.1 PIK46747.1 - 0.13 12.3 1.0 16 5.6 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-like domain Acetyltransf_15 PF17013.5 PIK46747.1 - 0.13 11.7 0.2 4.9 6.5 0.0 2.2 1 1 1 2 2 2 0 Putative acetyl-transferase FlgD_ig PF13860.6 PIK46747.1 - 0.15 11.9 0.1 19 5.2 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain IL17 PF06083.11 PIK46748.1 - 3.2e-16 59.5 1.5 5.9e-16 58.7 1.5 1.4 1 0 0 1 1 1 1 Interleukin-17 Ald_Xan_dh_C2 PF02738.18 PIK46749.1 - 8.6e-49 166.4 0.0 9.5e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C2 PF02738.18 PIK46750.1 - 3e-64 217.5 0.5 4e-64 217.0 0.5 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 PIK46750.1 - 3e-47 160.5 0.0 5e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 PIK46750.1 - 5.8e-31 107.1 0.1 1.2e-30 106.1 0.1 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 PIK46750.1 - 1.5e-28 99.0 0.0 4.1e-28 97.6 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain FH2 PF02181.23 PIK46752.1 - 9.4e-83 278.4 17.3 2.8e-82 276.8 17.3 1.8 1 0 0 1 1 1 1 Formin Homology 2 Domain Phasin PF05597.11 PIK46752.1 - 0.4 10.7 6.6 1.9 8.5 0.4 3.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Drf_FH3 PF06367.16 PIK46753.1 - 3.8e-09 36.5 0.1 6.5e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain G_glu_transpept PF01019.21 PIK46753.1 - 0.019 13.8 0.0 0.023 13.5 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Pox_L3_FP4 PF03339.14 PIK46753.1 - 0.2 10.6 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein EGF_2 PF07974.13 PIK46757.1 - 1.9e-10 40.9 109.4 0.00018 21.8 10.0 8.0 8 0 0 8 8 8 6 EGF-like domain NHL PF01436.21 PIK46757.1 - 4e-05 23.4 0.0 1.3 9.2 0.0 4.3 4 0 0 4 4 4 2 NHL repeat EGF_Tenascin PF18720.1 PIK46757.1 - 0.00077 19.4 12.7 0.0054 16.8 6.0 8.3 9 0 0 9 9 9 4 Tenascin EGF domain CarboxypepD_reg PF13620.6 PIK46757.1 - 0.053 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain V-set PF07686.17 PIK46758.1 - 4.1e-16 59.1 0.4 5.2e-05 23.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK46758.1 - 2.4e-08 34.4 0.3 0.016 15.8 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK46758.1 - 1.3e-06 28.3 0.0 0.18 11.9 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Sushi PF00084.20 PIK46758.1 - 0.002 18.7 0.3 0.011 16.3 0.3 2.3 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) PIP5K PF01504.18 PIK46758.1 - 0.09 12.0 0.3 0.15 11.2 0.0 1.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF1533 PF07550.11 PIK46758.1 - 0.13 12.2 1.0 1.5 8.7 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1533) DUF3439 PF11921.8 PIK46758.1 - 2 8.4 11.0 4.2 7.3 11.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 PIK46758.1 - 9.4 6.2 18.3 17 5.3 18.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein WSC PF01822.19 PIK46759.1 - 1.1e-07 31.9 4.1 1.1e-07 31.9 4.1 2.1 2 0 0 2 2 2 1 WSC domain Sushi PF00084.20 PIK46759.1 - 0.00035 21.1 0.4 0.00082 19.9 0.4 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) WSC PF01822.19 PIK46760.1 - 3.1e-13 49.7 7.9 6.6e-13 48.7 7.9 1.6 1 0 0 1 1 1 1 WSC domain Sushi PF00084.20 PIK46760.1 - 0.003 18.1 1.4 0.0075 16.8 0.8 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) AROS PF15684.5 PIK46761.1 - 1.2e-18 67.9 11.2 1.5e-18 67.6 11.2 1.1 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 Sulfotransfer_3 PF13469.6 PIK46762.1 - 2.5e-09 37.9 0.0 1.3e-07 32.2 0.0 2.3 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK46762.1 - 1.1e-06 28.3 0.4 2.4e-05 24.0 0.3 2.5 2 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 PIK46762.1 - 0.023 14.6 0.3 0.15 11.9 0.3 2.1 1 1 0 1 1 1 0 Sulfotransferase family TPR_19 PF14559.6 PIK46763.1 - 8.6e-24 83.8 9.2 8.9e-06 26.1 1.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK46763.1 - 1.5e-13 50.7 21.8 1.9e-07 31.2 0.1 5.6 4 2 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 PIK46763.1 - 1.8e-09 37.0 29.9 0.007 16.4 0.1 8.7 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46763.1 - 4.2e-09 36.5 6.0 0.09 13.6 0.0 7.1 7 2 1 8 8 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46763.1 - 1.3e-08 34.4 11.1 0.00051 20.0 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK46763.1 - 5.6e-07 30.1 0.5 0.077 13.7 0.0 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK46763.1 - 1e-06 28.8 1.0 0.0086 16.2 0.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK46763.1 - 1.2e-06 28.1 4.3 0.22 11.6 0.4 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK46763.1 - 2.7e-06 27.7 8.0 3.7 8.4 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK46763.1 - 0.00084 19.6 11.2 0.0033 17.7 0.1 4.8 6 0 0 6 6 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46763.1 - 0.0014 18.4 29.3 0.0017 18.1 0.1 6.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK46763.1 - 0.0036 17.5 16.8 1.8 8.9 0.5 6.7 5 3 0 6 6 6 2 Tetratricopeptide repeat PPR_2 PF13041.6 PIK46763.1 - 0.0063 16.7 3.2 10 6.4 0.1 4.0 3 1 1 4 4 4 0 PPR repeat family Coatomer_E PF04733.14 PIK46763.1 - 0.011 15.2 2.6 0.023 14.1 0.4 2.7 2 1 1 3 3 3 0 Coatomer epsilon subunit TPR_11 PF13414.6 PIK46763.1 - 0.023 14.4 1.0 0.34 10.6 0.0 3.2 3 0 0 3 3 3 0 TPR repeat Fis1_TPR_C PF14853.6 PIK46763.1 - 0.038 14.1 1.3 1.7 8.7 0.3 3.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 PIK46763.1 - 0.05 14.2 0.0 42 5.2 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat FMN_red PF03358.15 PIK46763.1 - 0.17 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 NADPH-dependent FMN reductase PPR PF01535.20 PIK46763.1 - 0.44 10.9 10.0 7.9 7.0 0.1 5.7 7 0 0 7 7 6 0 PPR repeat TMC PF07810.13 PIK46764.1 - 7.7e-19 68.3 5.9 7.5e-08 32.9 0.3 4.2 2 1 0 3 3 3 2 TMC domain FA_desaturase PF00487.24 PIK46764.1 - 0.22 11.3 4.0 4 7.2 0.0 2.6 3 0 0 3 3 3 0 Fatty acid desaturase COX2_TM PF02790.15 PIK46764.1 - 3.4 7.9 6.9 6.8 6.9 0.4 3.7 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain TMC PF07810.13 PIK46765.1 - 1.6e-40 138.1 3.6 1.6e-40 138.1 3.6 3.5 3 0 0 3 3 3 1 TMC domain Vma12 PF11712.8 PIK46765.1 - 0.072 13.1 0.1 0.31 11.1 0.1 2.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3456 PF11938.8 PIK46766.1 - 3.1e-32 112.2 1.4 4.4e-32 111.8 1.4 1.2 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Ank_4 PF13637.6 PIK46767.1 - 0.002 18.6 0.0 0.0025 18.4 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK46767.1 - 0.0094 16.3 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK46767.1 - 0.02 15.3 0.0 0.079 13.4 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 PIK46768.1 - 1.6e-25 89.5 0.0 3.2e-14 53.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK46768.1 - 5.4e-18 64.6 0.0 1.1e-06 28.8 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK46768.1 - 2.6e-17 62.6 0.1 1.4e-08 34.8 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK46768.1 - 3e-17 62.7 0.0 1.9e-08 34.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46768.1 - 1.2e-15 56.0 0.0 2.8e-05 24.1 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat CclA_1 PF16942.5 PIK46768.1 - 0.017 15.4 0.1 0.021 15.1 0.1 1.1 1 0 0 1 1 1 0 Putative cyclic bacteriocin Dimer_Tnp_hAT PF05699.14 PIK46772.1 - 0.00046 19.9 0.2 0.0011 18.7 0.2 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region FH2 PF02181.23 PIK46773.1 - 2.8e-65 220.8 1.5 2.8e-65 220.8 1.5 3.9 4 1 1 5 5 5 3 Formin Homology 2 Domain Drf_FH3 PF06367.16 PIK46773.1 - 9.1e-08 31.9 0.3 9.1e-08 31.9 0.3 2.6 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 PIK46773.1 - 4.1e-06 26.5 0.1 4.1e-06 26.5 0.1 2.2 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain DUF2433 PF10360.9 PIK46773.1 - 0.071 13.2 2.9 1.6 8.8 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) PPR_3 PF13812.6 PIK46773.1 - 0.09 12.9 0.1 6.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PP_kinase_N PF13089.6 PIK46773.1 - 0.1 13.0 2.2 1.5 9.2 0.1 3.6 3 1 0 3 3 3 0 Polyphosphate kinase N-terminal domain Filo_glycop PF01611.16 PIK46773.1 - 0.52 9.2 3.4 0.83 8.5 3.4 1.2 1 0 0 1 1 1 0 Filovirus glycoprotein TPR_8 PF13181.6 PIK46775.1 - 8.5e-10 38.1 1.3 0.02 15.0 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46775.1 - 0.00026 20.7 4.0 1.2 9.1 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK46775.1 - 0.0014 18.6 4.9 2.3 8.5 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK46775.1 - 0.0016 18.7 1.5 0.0098 16.2 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK46775.1 - 0.0045 17.1 0.3 0.0088 16.1 0.1 1.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_12 PF13424.6 PIK46775.1 - 0.0069 16.7 0.8 1.4 9.2 0.1 2.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK46775.1 - 0.0086 16.8 0.3 2.3 9.3 0.3 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK46775.1 - 0.012 15.8 1.3 4.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK46775.1 - 0.051 14.1 0.3 0.72 10.4 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK46775.1 - 0.1 12.5 1.0 0.6 10.1 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK46775.1 - 0.26 12.0 2.5 0.84 10.3 0.3 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK46775.1 - 0.43 11.3 2.6 41 5.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4363 PF14276.6 PIK46776.1 - 0.11 12.6 4.7 2.6 8.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) KxDL PF10241.9 PIK46777.1 - 0.0097 16.2 3.8 0.0097 16.2 3.8 7.5 4 3 3 7 7 7 2 Uncharacterized conserved protein DUF4485 PF14846.6 PIK46778.1 - 4e-30 103.7 1.1 8.4e-30 102.7 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4485) DLP_helical PF18709.1 PIK46778.1 - 0.0015 17.8 15.2 0.0022 17.3 15.2 1.2 1 0 0 1 1 1 1 Dynamin-like helical domain Luteo_PO PF04662.13 PIK46778.1 - 0.055 13.1 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 Luteovirus P0 protein DUF2935 PF11155.8 PIK46778.1 - 3.6 7.9 13.8 11 6.3 0.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) zf-RING_9 PF13901.6 PIK46778.1 - 5.1 7.0 8.6 11 5.9 8.4 1.6 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon DUF4407 PF14362.6 PIK46778.1 - 9.4 5.5 14.7 15 4.8 14.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pox_A51 PF04948.13 PIK46779.1 - 0.067 12.0 0.0 0.31 9.9 0.0 1.9 2 0 0 2 2 2 0 Poxvirus A51 protein DTHCT PF08070.11 PIK46780.1 - 1.4e-05 25.7 6.8 2e-05 25.3 6.8 1.2 1 0 0 1 1 1 1 DTHCT (NUC029) region DNA_gyraseB PF00204.25 PIK46781.1 - 1.8e-27 95.9 0.5 3.2e-27 95.1 0.5 1.4 1 0 0 1 1 1 1 DNA gyrase B TOPRIM_C PF16898.5 PIK46781.1 - 5e-24 85.0 6.5 5e-24 85.0 6.5 2.2 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_topoisoIV PF00521.20 PIK46781.1 - 1e-17 64.2 0.0 9.5e-12 44.5 0.0 2.5 2 0 0 2 2 2 2 DNA gyrase/topoisomerase IV, subunit A HATPase_c PF02518.26 PIK46781.1 - 4.9e-14 52.8 0.0 1.3e-13 51.5 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 PIK46781.1 - 3.9e-05 23.8 0.5 0.00018 21.7 0.5 2.2 1 1 0 1 1 1 1 Toprim domain UQ_con PF00179.26 PIK46782.1 - 6.9e-40 135.9 0.0 7.8e-40 135.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Sulfotransfer_2 PF03567.14 PIK46783.1 - 3.5e-29 102.5 0.8 4.4e-29 102.2 0.8 1.1 1 0 0 1 1 1 1 Sulfotransferase family TSP_1 PF00090.19 PIK46784.1 - 1.1e-15 57.6 70.0 9.4e-06 25.8 7.4 6.0 6 0 0 6 6 6 5 Thrombospondin type 1 domain VP7 PF00434.18 PIK46784.1 - 0.0047 16.1 19.8 0.22 10.6 5.1 3.2 1 1 2 3 3 3 3 Glycoprotein VP7 HTH_ABP1_N PF18107.1 PIK46784.1 - 0.039 13.7 0.0 74 3.2 0.0 3.3 3 0 0 3 3 3 0 Fission yeast centromere protein N-terminal domain Meiotic_rec114 PF03525.14 PIK46784.1 - 0.14 11.1 1.4 2.9 6.8 0.0 2.7 3 0 0 3 3 3 0 Meiotic recombination protein rec114 Cadherin_tail PF15974.5 PIK46784.1 - 0.21 11.9 3.1 3.9 7.8 0.1 3.4 1 1 3 4 4 4 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region DUF5027 PF16430.5 PIK46784.1 - 1.4 8.7 4.5 30 4.3 0.3 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5027) Ras PF00071.22 PIK46785.1 - 3.3e-13 49.5 0.8 4.3e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK46785.1 - 8.5e-05 22.8 0.1 0.00016 21.8 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 PIK46785.1 - 0.027 14.0 0.1 0.069 12.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 PIK46785.1 - 0.037 13.6 0.1 0.095 12.2 0.1 1.7 1 1 1 2 2 2 0 Ferrous iron transport protein B NB-ARC PF00931.22 PIK46785.1 - 0.053 12.7 0.8 1.9 7.6 0.1 2.1 1 1 1 2 2 2 0 NB-ARC domain TniB PF05621.11 PIK46785.1 - 0.066 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Arf PF00025.21 PIK46785.1 - 0.12 11.8 0.0 18 4.7 0.0 2.4 2 1 0 2 2 2 0 ADP-ribosylation factor family DnaJ PF00226.31 PIK46787.1 - 4.5e-20 71.5 1.4 7.9e-20 70.7 1.4 1.4 1 0 0 1 1 1 1 DnaJ domain TM2 PF05154.16 PIK46787.1 - 1.1e-12 48.0 10.6 1.1e-12 48.0 10.6 2.1 2 0 0 2 2 2 1 TM2 domain Phage_holin_5_2 PF16079.5 PIK46787.1 - 0.93 9.9 3.7 1.6 9.1 0.0 2.7 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V WD40 PF00400.32 PIK46788.1 - 1.8e-19 69.7 18.3 4.5e-08 33.6 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat HEAT_2 PF13646.6 PIK46788.1 - 0.0035 17.7 0.1 0.0094 16.3 0.1 1.7 1 0 0 1 1 1 1 HEAT repeats Astro_capsid_p PF12226.8 PIK46788.1 - 5.3 6.1 12.1 13 4.8 12.1 1.6 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Peptidase_A17 PF05380.13 PIK46791.1 - 2.8e-55 186.8 0.0 3.6e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 Pao retrotransposon peptidase DNA_pol_viral_C PF00336.18 PIK46791.1 - 0.023 14.1 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain DUF1803 PF08820.10 PIK46791.1 - 0.044 13.8 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) BBIP10 PF14777.6 PIK46791.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RVT_1 PF00078.27 PIK46792.1 - 0.031 13.8 0.0 0.067 12.7 0.0 1.5 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LEA_6 PF10714.9 PIK46792.1 - 0.15 12.2 0.2 0.57 10.3 0.0 1.9 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 DUF4834 PF16118.5 PIK46793.1 - 0.00014 22.8 7.2 0.00014 22.8 7.2 14.2 3 3 7 10 10 3 1 Domain of unknown function (DUF4834) DUF2207 PF09972.9 PIK46793.1 - 0.00077 18.3 8.1 0.00077 18.3 8.1 6.9 4 2 1 6 6 3 1 Predicted membrane protein (DUF2207) TraG_N PF07916.11 PIK46793.1 - 0.0029 16.5 7.0 0.0029 16.5 7.0 6.1 3 2 3 6 6 3 1 TraG-like protein, N-terminal region OPT PF03169.15 PIK46793.1 - 0.0038 15.9 4.8 0.0038 15.9 4.8 6.1 4 1 2 6 6 4 1 OPT oligopeptide transporter protein LAP1C PF05609.12 PIK46793.1 - 0.004 16.3 4.5 0.004 16.3 4.5 4.7 2 1 3 5 5 5 2 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 PIK46793.1 - 0.006 16.9 1.6 0.006 16.9 1.6 13.1 4 4 5 9 9 4 3 Orf78 (ac78) EphA2_TM PF14575.6 PIK46793.1 - 0.0063 17.4 1.8 0.0063 17.4 1.8 15.4 4 4 8 12 12 3 2 Ephrin type-A receptor 2 transmembrane domain MARVEL PF01284.23 PIK46793.1 - 0.0068 16.4 4.0 0.0068 16.4 4.0 6.1 1 1 4 5 5 3 2 Membrane-associating domain Tmemb_9 PF05434.11 PIK46793.1 - 0.0082 16.0 1.6 0.0082 16.0 1.6 12.9 4 3 5 9 9 2 1 TMEM9 Pex14_N PF04695.13 PIK46793.1 - 0.034 14.8 1.2 0.034 14.8 1.2 5.2 4 1 1 5 5 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3671 PF12420.8 PIK46793.1 - 0.075 13.1 0.3 0.075 13.1 0.3 11.2 3 2 3 6 6 3 0 Protein of unknown function PBP1_TM PF14812.6 PIK46793.1 - 0.12 12.8 0.2 0.12 12.8 0.2 6.0 6 3 0 6 6 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3043 PF11241.8 PIK46793.1 - 0.39 10.7 0.0 0.39 10.7 0.0 7.1 5 2 1 6 6 1 0 Protein of unknown function (DUF3043) DUF1676 PF07898.13 PIK46793.1 - 1.7 8.7 0.0 1.7 8.7 0.0 7.1 4 3 2 6 6 3 0 Protein of unknown function (DUF1676) DUF737 PF05300.11 PIK46793.1 - 2.2 8.6 0.0 2.2 8.6 0.0 4.3 2 1 0 2 2 1 0 Protein of unknown function (DUF737) PALP PF00291.25 PIK46794.1 - 2.9e-64 217.3 0.5 3.4e-64 217.1 0.5 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SNARE_assoc PF09335.11 PIK46795.1 - 2.1e-20 73.4 4.5 2.1e-20 73.4 4.5 1.9 3 0 0 3 3 3 1 SNARE associated Golgi protein DctQ PF04290.12 PIK46795.1 - 0.00092 19.1 1.2 0.00092 19.1 1.2 2.7 2 1 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component Vps53_N PF04100.12 PIK46795.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal UPF0016 PF01169.19 PIK46795.1 - 0.15 12.4 6.1 7 7.1 1.5 2.8 3 0 0 3 3 3 0 Uncharacterized protein family UPF0016 DUF2007 PF09413.10 PIK46796.1 - 0.2 11.8 0.0 0.59 10.3 0.0 1.7 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein SEFIR PF08357.11 PIK46797.1 - 0.022 15.1 0.0 0.03 14.6 0.0 1.1 1 0 0 1 1 1 0 SEFIR domain TIR_2 PF13676.6 PIK46797.1 - 0.024 15.2 0.0 0.026 15.1 0.0 1.1 1 0 0 1 1 1 0 TIR domain DUF727 PF05303.12 PIK46797.1 - 0.089 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF727) Dimer_Tnp_hAT PF05699.14 PIK46798.1 - 2.4e-10 40.0 0.0 6.1e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK46798.1 - 1.1e-06 28.4 0.1 2.4e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK46798.1 - 2.2e-05 24.3 0.7 5.2e-05 23.2 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Neur_chan_LBD PF02931.23 PIK46799.1 - 9.5e-17 61.2 0.0 1.4e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK46799.1 - 8.1e-09 35.9 1.1 1.2e-08 35.3 1.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region LMF1 PF06762.14 PIK46800.1 - 6.8e-133 444.0 14.6 2e-99 333.7 1.2 2.1 1 1 1 2 2 2 2 Lipase maturation factor Pro-kuma_activ PF09286.11 PIK46800.1 - 0.024 14.9 0.3 0.058 13.7 0.3 1.6 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain SPARC_Ca_bdg PF10591.9 PIK46800.1 - 0.14 12.5 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MBF2 PF15868.5 PIK46801.1 - 7.4e-21 74.5 0.1 1.3e-20 73.7 0.1 1.4 1 1 0 1 1 1 1 Transcription activator MBF2 Bromodomain PF00439.25 PIK46803.1 - 6.3e-22 77.4 0.1 1.2e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Glyco_trans_1_2 PF13524.6 PIK46803.1 - 0.42 11.0 9.0 3.7 8.0 4.8 3.0 2 1 1 3 3 3 0 Glycosyl transferases group 1 zf-C4 PF00105.18 PIK46804.1 - 2.1e-32 111.4 14.6 5e-32 110.2 14.6 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK46804.1 - 7.4e-14 51.8 2.8 2e-13 50.4 2.8 1.7 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor HAND PF09110.11 PIK46805.1 - 0.057 14.2 0.6 0.1 13.3 0.6 1.4 1 0 0 1 1 1 0 HAND zf-CCHC_4 PF14392.6 PIK46805.1 - 0.088 12.6 0.6 0.088 12.6 0.6 2.4 1 1 1 2 2 2 0 Zinc knuckle Myticin-prepro PF10690.9 PIK46805.1 - 0.26 11.5 3.6 0.49 10.7 3.6 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel zf-CCHC_3 PF13917.6 PIK46805.1 - 1.2 9.2 15.3 1.2 9.2 8.9 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 PIK46805.1 - 3 8.1 18.6 1 9.5 5.6 2.8 3 0 0 3 3 3 0 Zinc knuckle DNA_pol_B_2 PF03175.13 PIK46807.1 - 0.089 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral MRG PF05712.13 PIK46807.1 - 0.12 11.6 0.1 1.1 8.5 0.0 1.9 1 1 1 2 2 2 0 MRG Ribonuc_2-5A PF06479.12 PIK46808.1 - 0.091 12.9 0.7 0.15 12.2 0.2 1.6 2 0 0 2 2 2 0 Ribonuclease 2-5A HECT PF00632.25 PIK46809.1 - 1.2e-05 25.0 0.5 0.00018 21.1 0.2 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) UBX PF00789.20 PIK46810.1 - 1.9e-06 28.0 0.0 6e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 UBX domain Ribosomal_L6e PF01159.19 PIK46810.1 - 0.18 12.3 0.7 17 6.0 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein L6e Dimer_Tnp_hAT PF05699.14 PIK46812.1 - 1.5e-08 34.3 0.6 3.6e-08 33.1 0.6 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK46813.1 - 6.8e-29 101.2 0.7 1.3e-28 100.3 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK46813.1 - 0.0026 17.6 0.5 0.01 15.7 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) rve PF00665.26 PIK46814.1 - 4.4e-21 75.3 0.0 5.4e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK46814.1 - 0.0051 16.6 0.0 0.0059 16.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.27 PIK46815.1 - 4.5e-09 36.1 0.0 1.2e-08 34.7 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46816.1 - 5e-23 81.6 0.0 9.3e-23 80.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46816.1 - 1.2e-19 70.1 1.9 2.4e-19 69.2 1.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK46816.1 - 7e-10 39.1 0.0 2.4e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK46816.1 - 0.00022 21.3 0.9 0.00074 19.7 0.9 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK46816.1 - 0.00029 20.5 0.2 0.0012 18.6 0.2 2.1 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK46816.1 - 0.0037 17.3 0.0 0.0077 16.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SprT-like PF10263.9 PIK46816.1 - 0.095 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 SprT-like family RVP PF00077.20 PIK46818.1 - 0.051 13.9 0.0 0.13 12.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 PIK46818.1 - 0.14 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK46819.1 - 2.6e-06 27.3 16.2 0.001 19.0 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46819.1 - 0.0018 18.1 8.2 0.17 11.8 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46819.1 - 0.014 15.3 12.6 0.37 10.8 1.2 3.6 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46819.1 - 0.035 13.9 0.2 0.035 13.9 0.2 3.8 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK46819.1 - 0.036 13.8 0.8 0.036 13.8 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK46819.1 - 0.11 12.2 11.1 7.8 6.3 0.4 3.5 2 1 1 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK46820.1 - 3.9e-09 36.4 0.1 1.1e-05 25.0 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) UBX PF00789.20 PIK46821.1 - 0.004 17.3 0.0 0.0096 16.1 0.0 1.6 1 0 0 1 1 1 1 UBX domain YfkB PF08756.10 PIK46822.1 - 0.096 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 YfkB-like domain zf-CCHC PF00098.23 PIK46823.1 - 2e-05 24.5 16.1 0.0032 17.5 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK46823.1 - 6e-05 22.8 6.2 0.0029 17.4 0.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK46823.1 - 0.00021 20.9 14.2 0.47 10.2 1.1 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK46823.1 - 1.7 8.9 12.4 0.55 10.5 6.9 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK46823.1 - 5.5 6.8 12.9 0.87 9.4 0.3 3.8 4 0 0 4 4 4 0 C2H2 zinc-finger RVT_1 PF00078.27 PIK46824.1 - 4.9e-35 121.0 0.0 6.1e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK46826.1 - 6.9e-06 25.9 16.8 4.8e-05 23.3 1.6 3.4 3 0 0 3 3 3 2 Zinc knuckle Exo_endo_phos_2 PF14529.6 PIK46826.1 - 0.0005 19.9 0.0 0.0015 18.4 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-CCHC_6 PF15288.6 PIK46826.1 - 0.0089 15.8 7.0 0.27 11.1 0.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Mt_ATP-synt_B PF05405.14 PIK46826.1 - 0.028 14.1 2.2 0.066 12.8 2.2 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) zf-CCHC_4 PF14392.6 PIK46826.1 - 1.1 9.0 15.2 0.52 10.1 0.5 3.6 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK46826.1 - 1.7 8.7 19.4 1.4 8.9 2.7 4.2 2 1 1 3 3 3 0 Zinc knuckle FMO-like PF00743.19 PIK46827.1 - 6.8e-55 186.5 0.1 6.9e-30 104.0 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 PIK46827.1 - 0.074 12.3 0.1 0.1 11.8 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RST PF12174.8 PIK46827.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain FMO-like PF00743.19 PIK46828.1 - 3.7e-132 441.5 0.1 7.3e-71 239.2 0.1 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK46828.1 - 1.7e-13 50.5 2.6 2.8e-11 43.2 0.1 2.5 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK46828.1 - 1.9e-10 40.5 0.0 4.4e-07 29.4 0.0 2.1 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK46828.1 - 2.5e-08 33.4 3.1 7.8e-07 28.6 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK46828.1 - 2.4e-05 24.5 0.0 5.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 PIK46828.1 - 0.00052 20.0 0.0 5.3 7.0 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 PIK46828.1 - 0.011 15.0 0.3 0.044 13.1 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 PIK46828.1 - 0.012 15.2 1.2 6.9 6.1 0.0 3.1 2 1 0 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK46828.1 - 0.082 11.6 0.2 0.18 10.4 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein Cullin PF00888.22 PIK46829.1 - 1.2e-25 90.2 3.0 1.2e-25 90.2 3.0 1.7 2 0 0 2 2 2 1 Cullin family HTH_DeoR PF08220.12 PIK46829.1 - 0.081 12.7 0.0 0.25 11.1 0.0 1.9 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Ribosomal_L28 PF00830.19 PIK46829.1 - 0.14 12.3 1.4 0.32 11.2 0.0 2.3 2 1 1 3 3 3 0 Ribosomal L28 family BSP_II PF05432.11 PIK46829.1 - 0.26 11.0 8.5 0.043 13.5 1.5 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TMEM108 PF15759.5 PIK46829.1 - 0.41 9.6 2.9 0.65 8.9 2.9 1.2 1 0 0 1 1 1 0 TMEM108 family Kinetochor_Ybp2 PF08568.10 PIK46830.1 - 3.6e-31 108.4 12.4 2.3e-29 102.4 12.4 2.4 1 1 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin FAM209 PF15206.6 PIK46830.1 - 0.067 13.0 0.2 1.3 8.8 0.0 2.6 2 1 1 3 3 3 0 FAM209 family HSP70 PF00012.20 PIK46831.1 - 3.2e-190 633.3 17.4 1.6e-184 614.5 6.1 2.8 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK46831.1 - 9.1e-13 47.7 0.1 1.6e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 PIK46831.1 - 0.0095 15.2 0.1 0.021 14.1 0.1 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Spore_GerAC PF05504.11 PIK46831.1 - 0.54 10.5 0.0 0.54 10.5 0.0 3.0 4 0 0 4 4 4 0 Spore germination B3/ GerAC like, C-terminal MMtag PF10159.9 PIK46831.1 - 4.1 7.8 0.0 4.1 7.8 0.0 3.4 3 1 0 3 3 3 0 Multiple myeloma tumor-associated DUF1542 PF07564.11 PIK46831.1 - 9.4 6.4 10.0 2.3 8.4 5.7 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) TrbI PF03743.14 PIK46833.1 - 0.022 14.6 0.2 0.033 14.0 0.2 1.2 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein RT_RNaseH_2 PF17919.1 PIK46835.1 - 3.8e-33 113.5 0.1 9.9e-33 112.2 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46835.1 - 4.9e-28 97.5 0.0 1.3e-27 96.1 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK46835.1 - 1.3e-18 67.4 0.0 2.6e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46835.1 - 3.4e-17 62.7 0.0 8.4e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46835.1 - 7.2e-16 58.0 0.2 6.6e-15 55.0 0.5 2.7 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 PIK46835.1 - 0.0015 19.1 0.0 0.0039 17.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 PIK46835.1 - 0.0029 17.8 0.0 0.013 15.7 0.0 2.3 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 PIK46835.1 - 0.0038 17.2 2.6 0.0038 17.2 2.6 2.3 2 0 0 2 2 2 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK46835.1 - 0.033 14.5 0.1 0.12 12.7 0.1 2.0 1 0 0 1 1 1 0 Retrotransposon gag protein Asp_protease_2 PF13650.6 PIK46835.1 - 0.037 14.7 0.0 0.083 13.5 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease EGF_2 PF07974.13 PIK46836.1 - 0.00017 21.9 12.2 0.00017 21.9 12.2 4.5 3 2 0 3 3 3 2 EGF-like domain hEGF PF12661.7 PIK46836.1 - 0.0018 18.8 4.9 0.0018 18.8 4.9 5.4 6 0 0 6 6 6 1 Human growth factor-like EGF EGF PF00008.27 PIK46836.1 - 0.013 15.8 11.6 0.013 15.8 11.6 5.1 6 1 0 6 6 6 0 EGF-like domain Laminin_EGF PF00053.24 PIK46836.1 - 0.43 10.7 37.8 0.19 11.9 9.2 3.8 3 1 1 4 4 4 0 Laminin EGF domain LRR_10 PF18805.1 PIK46838.1 - 0.1 12.3 0.9 1.4 8.6 0.6 2.3 1 1 1 2 2 2 0 Leucine-rich repeat Y_phosphatase PF00102.27 PIK46839.1 - 1.4e-106 355.4 4.8 1.1e-65 221.5 0.2 3.5 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK46839.1 - 0.007 16.2 1.2 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK46839.1 - 0.018 15.2 0.6 0.085 13.0 0.0 2.4 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK46839.1 - 0.058 13.4 0.0 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family Cnd1 PF12717.7 PIK46839.1 - 0.074 13.1 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Tk-SP_N-pro PF18237.1 PIK46839.1 - 0.12 12.4 0.0 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Tk-SP N-propeptide domain RT_RNaseH PF17917.1 PIK46840.1 - 1.1e-31 109.2 0.2 6.7e-31 106.7 0.1 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46840.1 - 1.3e-23 83.0 0.2 3.3e-23 81.6 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK46840.1 - 1.6e-22 79.9 0.0 3.9e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46840.1 - 9.9e-15 54.4 3.1 4.4e-14 52.3 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK46840.1 - 4.9e-05 23.0 0.1 0.00014 21.6 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain bVLRF1 PF18826.1 PIK46840.1 - 0.18 11.6 1.7 4.5 7.1 0.0 2.6 2 0 0 2 2 2 0 bacteroidetes VLRF1 release factor RVT_1 PF00078.27 PIK46841.1 - 5.3e-27 94.8 0.0 7.8e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IMPDH PF00478.25 PIK46842.1 - 1.2e-124 415.8 4.9 1.5e-124 415.5 4.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 PIK46842.1 - 4.4e-13 49.3 0.3 4.9e-10 39.3 0.5 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase CBS PF00571.28 PIK46842.1 - 8.6e-12 45.3 0.2 0.00013 22.4 0.0 3.0 3 0 0 3 3 3 2 CBS domain FMN_dh PF01070.18 PIK46842.1 - 1.9e-09 37.0 0.5 4.9e-09 35.7 0.6 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 PIK46842.1 - 2.8e-08 33.5 3.5 9.8e-06 25.2 0.6 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein NanE PF04131.14 PIK46842.1 - 0.00095 18.4 1.8 0.0016 17.7 0.4 2.0 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Aldolase PF01081.19 PIK46842.1 - 0.001 18.5 0.7 0.0062 16.0 0.2 2.1 2 0 0 2 2 2 1 KDPG and KHG aldolase ThiG PF05690.14 PIK46842.1 - 0.0047 16.3 2.2 0.0061 15.9 1.1 1.6 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 PIK46842.1 - 0.0065 15.7 3.1 0.012 14.8 3.1 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.21 PIK46842.1 - 0.0089 15.3 4.1 0.032 13.5 0.4 2.5 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase BATS PF06968.13 PIK46842.1 - 0.021 14.9 0.1 0.62 10.2 0.0 2.9 2 1 1 3 3 3 0 Biotin and Thiamin Synthesis associated domain G3P_antiterm PF04309.12 PIK46842.1 - 0.051 13.0 0.9 1.8 7.9 0.1 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator ADH_zinc_N PF00107.26 PIK46842.1 - 0.08 12.9 1.3 0.3 11.1 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding dehydrogenase PcrB PF01884.17 PIK46842.1 - 1.3 8.5 3.8 51 3.2 0.0 3.8 3 1 0 5 5 5 0 PcrB family HYR PF02494.16 PIK46844.1 - 4.8e-12 46.0 5.6 2.6e-07 30.9 0.8 2.6 2 1 0 2 2 2 2 HYR domain SEA PF01390.20 PIK46844.1 - 1.9e-08 34.3 0.7 4e-08 33.3 0.7 1.4 1 0 0 1 1 1 1 SEA domain DUF1735 PF08522.10 PIK46844.1 - 0.014 16.0 2.3 0.3 11.7 0.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1735) AAR2 PF05282.11 PIK46844.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 AAR2 protein Carboxyl_trans PF01039.22 PIK46845.1 - 2.2e-36 125.5 0.1 2.5e-36 125.4 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 PIK46845.1 - 0.0041 16.6 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) RRM_1 PF00076.22 PIK46846.1 - 1.7e-51 171.9 0.2 8.4e-18 64.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK46846.1 - 1.2e-08 34.9 0.1 0.2 11.8 0.1 4.2 3 3 1 4 4 4 3 RNA recognition motif RRM_3 PF08777.11 PIK46846.1 - 0.046 13.8 0.2 0.4 10.7 0.1 2.5 2 1 1 3 3 3 0 RNA binding motif KIAA1328 PF15369.6 PIK46847.1 - 4.3e-16 59.6 17.5 4.3e-16 59.6 17.5 2.0 1 1 1 2 2 2 1 Uncharacterised protein KIAA1328 APG6_N PF17675.1 PIK46847.1 - 0.06 13.9 17.5 0.11 13.0 17.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF3287 PF11690.8 PIK46847.1 - 0.069 12.9 2.5 0.12 12.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF3734 PF12536.8 PIK46847.1 - 0.15 12.4 7.5 0.09 13.1 2.2 2.6 1 1 2 3 3 3 0 Patatin phospholipase FAD-oxidase_C PF02913.19 PIK46848.1 - 3.9e-42 144.6 0.0 1.2e-41 143.1 0.0 1.7 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 PIK46848.1 - 3.5e-38 130.5 0.0 5.8e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 PIK46848.1 - 0.00049 20.1 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like Thioredoxin PF00085.20 PIK46849.1 - 2.4e-74 245.9 4.4 3.1e-24 84.9 0.0 4.3 4 0 0 4 4 4 4 Thioredoxin Thioredoxin_7 PF13899.6 PIK46849.1 - 3.8e-21 75.1 0.2 1e-07 32.0 0.0 4.1 4 0 0 4 4 4 3 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK46849.1 - 8.8e-20 71.2 3.1 2.8e-06 27.7 0.1 4.3 4 1 0 4 4 4 3 Thioredoxin-like domain AhpC-TSA PF00578.21 PIK46849.1 - 4e-18 65.5 1.8 1.5e-05 24.9 0.0 4.2 4 0 0 4 4 4 3 AhpC/TSA family Thioredoxin_8 PF13905.6 PIK46849.1 - 7e-16 58.3 0.7 0.006 16.9 0.0 5.1 4 1 1 5 5 5 3 Thioredoxin-like Redoxin PF08534.10 PIK46849.1 - 2.8e-10 40.1 0.4 0.029 14.1 0.0 3.6 3 0 0 3 3 3 3 Redoxin OST3_OST6 PF04756.13 PIK46849.1 - 3.6e-08 33.1 0.0 0.021 14.2 0.0 3.4 4 0 0 4 4 4 2 OST3 / OST6 family, transporter family TraF PF13728.6 PIK46849.1 - 6.1e-08 32.8 0.5 0.031 14.1 0.0 4.0 3 1 1 4 4 4 3 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 PIK46849.1 - 1.3e-06 28.4 0.3 0.14 12.1 0.1 4.2 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_9 PF14595.6 PIK46849.1 - 1.9e-05 24.4 0.6 0.38 10.5 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Glutaredoxin PF00462.24 PIK46849.1 - 0.0054 16.9 11.6 3 8.1 1.3 4.4 4 1 0 4 4 4 3 Glutaredoxin DUF836 PF05768.14 PIK46849.1 - 0.079 13.4 0.1 7.7 7.0 0.0 3.3 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) Thioredoxin PF00085.20 PIK46850.1 - 2.5e-35 120.6 0.0 2.9e-28 97.9 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 PIK46850.1 - 4.9e-09 36.6 0.1 1.7e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 PIK46850.1 - 8.3e-06 25.4 0.3 0.0036 16.7 0.1 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 PIK46850.1 - 1.6e-05 25.2 0.0 0.013 15.8 0.0 3.0 2 1 1 3 3 3 1 Thioredoxin-like HTH_6 PF01418.17 PIK46850.1 - 0.00027 20.8 0.0 0.19 11.8 0.0 2.6 3 0 0 3 3 3 2 Helix-turn-helix domain, rpiR family Thioredoxin_6 PF13848.6 PIK46850.1 - 0.0013 18.6 0.0 0.021 14.7 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 PIK46850.1 - 0.0027 17.6 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 PIK46850.1 - 0.005 17.0 0.0 0.0091 16.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 PIK46850.1 - 0.013 15.6 0.0 0.035 14.1 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin domain Redoxin PF08534.10 PIK46850.1 - 0.028 14.2 0.1 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Redoxin Glutaredoxin PF00462.24 PIK46850.1 - 0.029 14.6 0.1 0.49 10.7 0.1 2.4 2 0 0 2 2 2 0 Glutaredoxin TraF PF13728.6 PIK46850.1 - 0.061 13.1 0.1 5.7 6.7 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Abi_HHR PF07815.14 PIK46851.1 - 3.6e-30 103.9 0.3 6.4e-30 103.1 0.3 1.4 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.6 PIK46851.1 - 3.8e-15 55.5 0.2 7.3e-15 54.6 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK46851.1 - 9e-14 50.8 0.1 1.4e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK46851.1 - 9.6e-12 44.4 0.0 1.8e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain LRR_6 PF13516.6 PIK46852.1 - 1.5e-09 37.1 0.1 0.018 15.1 0.0 3.3 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.7 PIK46852.1 - 0.00023 21.5 0.2 0.16 12.4 0.1 2.7 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK46852.1 - 0.00039 20.6 2.0 0.4 11.4 0.5 3.4 2 1 0 2 2 2 2 Leucine Rich Repeat RE_XamI PF09572.10 PIK46852.1 - 0.14 11.8 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 XamI restriction endonuclease Helicase_C PF00271.31 PIK46853.1 - 2.4e-16 60.1 0.0 6.8e-16 58.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK46853.1 - 3e-07 30.4 0.0 6.8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-met PF12874.7 PIK46853.1 - 9.5e-05 22.7 1.3 0.0012 19.2 0.6 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type AAA_19 PF13245.6 PIK46853.1 - 0.002 18.4 0.0 0.0062 16.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 PIK46853.1 - 0.0061 16.8 1.3 0.018 15.3 0.2 2.3 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK46853.1 - 0.0099 15.8 0.1 0.57 10.1 0.0 2.4 2 0 0 2 2 2 1 NACHT domain ATPase PF06745.13 PIK46853.1 - 0.017 14.5 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 PIK46853.1 - 0.017 14.6 0.0 0.06 12.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 PIK46853.1 - 0.023 14.3 0.1 2.8 7.5 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain dsrm PF00035.26 PIK46853.1 - 0.033 14.9 0.1 0.14 12.9 0.0 2.2 2 0 0 2 2 1 0 Double-stranded RNA binding motif RsgA_GTPase PF03193.16 PIK46853.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PhoH PF02562.16 PIK46853.1 - 0.082 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 PIK46853.1 - 0.091 12.8 0.0 2.7 8.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain zf-C2H2_jaz PF12171.8 PIK46853.1 - 0.11 12.8 1.3 0.17 12.2 0.3 1.9 2 0 0 2 2 1 0 Zinc-finger double-stranded RNA-binding Dicer_dimer PF03368.14 PIK46853.1 - 0.11 12.6 0.0 6.1 7.1 0.0 2.8 2 0 0 2 2 2 0 Dicer dimerisation domain SRP54 PF00448.22 PIK46853.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 PIK46853.1 - 0.12 11.4 0.1 1.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein BTB_2 PF02214.22 PIK46854.1 - 6.3e-66 218.8 10.0 1.3e-18 67.1 0.0 5.1 4 1 1 5 5 5 5 BTB/POZ domain BTB_3 PF16017.5 PIK46854.1 - 1e-19 70.6 0.0 0.00097 19.2 0.0 4.7 5 0 0 5 5 5 4 BTB/POZ domain BTB PF00651.31 PIK46854.1 - 3.7e-18 65.8 2.1 0.003 17.8 0.0 5.2 4 1 1 5 5 5 5 BTB/POZ domain DUF4110 PF13422.6 PIK46854.1 - 0.0041 17.2 0.1 5.3 7.2 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4110) Reprolysin_3 PF13582.6 PIK46854.1 - 0.092 13.3 0.2 14 6.2 0.0 2.8 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like Siah-Interact_N PF09032.11 PIK46854.1 - 0.26 11.6 0.6 26 5.2 0.0 2.7 2 0 0 2 2 2 0 Siah interacting protein, N terminal OB_NTP_bind PF07717.16 PIK46855.1 - 9.4e-07 29.1 0.0 1.6e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 PIK46855.1 - 0.024 14.9 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) Pkinase PF00069.25 PIK46856.1 - 1.3e-77 260.7 0.0 1.5e-77 260.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK46856.1 - 3.8e-36 124.7 0.0 4.6e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK46856.1 - 7.8e-05 22.1 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK46856.1 - 0.0002 20.8 0.1 0.00035 20.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 PIK46856.1 - 0.0013 18.3 0.1 0.0022 17.6 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 PIK46856.1 - 0.0014 17.4 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK46856.1 - 0.021 14.8 0.1 1.1 9.2 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK46856.1 - 0.03 13.9 0.2 0.045 13.4 0.2 1.2 1 0 0 1 1 1 0 RIO1 family DCX PF03607.17 PIK46857.1 - 5.3e-22 77.7 0.0 8.3e-22 77.1 0.0 1.3 1 0 0 1 1 1 1 Doublecortin COesterase PF00135.28 PIK46858.1 - 1.5e-116 390.3 0.0 2.3e-116 389.7 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family RVT_1 PF00078.27 PIK46858.1 - 3.2e-33 115.1 0.1 5.5e-33 114.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Abhydrolase_3 PF07859.13 PIK46858.1 - 1.7e-06 28.1 1.5 1.3e-05 25.1 1.5 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Nt_Gln_amidase PF09764.9 PIK46859.1 - 4.2e-51 173.2 1.9 4.6e-51 173.1 1.9 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase BRO1 PF03097.18 PIK46860.1 - 5.4e-25 88.0 0.2 6.1e-25 87.8 0.2 1.0 1 0 0 1 1 1 1 BRO1-like domain EDS1_EP PF18117.1 PIK46861.1 - 0.013 16.0 1.0 0.041 14.3 1.3 1.7 2 0 0 2 2 2 0 Enhanced disease susceptibility 1 protein EP domain TnpV PF14198.6 PIK46861.1 - 0.023 14.7 1.8 0.035 14.1 1.8 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV RVT_1 PF00078.27 PIK46862.1 - 2.8e-23 82.6 0.1 3.4e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK46862.1 - 5.9e-22 77.6 0.0 8.9e-22 77.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46862.1 - 2.5e-20 72.7 0.0 5e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4441 PF14536.6 PIK46862.1 - 0.062 13.5 0.1 1.6 9.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) Integrase_H2C2 PF17921.1 PIK46863.1 - 9e-20 70.5 0.0 1.6e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK46863.1 - 0.00017 21.7 0.0 0.00035 20.7 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger BRO1 PF03097.18 PIK46864.1 - 1.2e-29 103.3 3.3 1.4e-15 57.0 0.4 2.3 1 1 1 2 2 2 2 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 PIK46864.1 - 3.1e-23 82.5 2.4 3.1e-23 82.5 2.4 1.8 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Ribosomal_L20 PF00453.18 PIK46864.1 - 0.013 15.5 2.0 0.61 10.2 0.4 2.6 2 1 0 2 2 2 0 Ribosomal protein L20 UPF0184 PF03670.13 PIK46864.1 - 0.14 12.6 1.3 0.94 9.9 0.7 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) ALIX_LYPXL_bnd PF13949.6 PIK46865.1 - 1.5e-43 149.2 3.4 2.1e-43 148.7 3.4 1.1 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV HEXIM PF15313.6 PIK46866.1 - 8.5e-24 84.4 10.7 1.8e-22 80.1 10.7 2.2 1 1 0 1 1 1 1 Hexamethylene bis-acetamide-inducible protein Mad3_BUB1_II PF08171.11 PIK46866.1 - 0.088 13.0 0.6 0.16 12.1 0.6 1.5 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 RRM_1 PF00076.22 PIK46867.1 - 3.9e-08 33.0 0.0 7.5e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK46867.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Ribul_P_3_epim PF00834.19 PIK46869.1 - 1.5e-47 161.6 0.3 1.7e-47 161.4 0.3 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 PIK46869.1 - 0.0008 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 PIK46869.1 - 0.0075 15.9 0.1 0.012 15.2 0.0 1.3 1 1 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family His_biosynth PF00977.21 PIK46869.1 - 0.02 14.4 0.1 0.045 13.2 0.0 1.6 1 1 0 1 1 1 0 Histidine biosynthesis protein Aldolase PF01081.19 PIK46869.1 - 0.026 13.9 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 KDPG and KHG aldolase TMP-TENI PF02581.17 PIK46869.1 - 0.027 13.8 0.1 0.069 12.5 0.1 1.6 1 1 0 1 1 1 0 Thiamine monophosphate synthase Radical_SAM PF04055.21 PIK46869.1 - 0.045 14.1 0.0 2.8 8.3 0.0 2.6 1 1 1 2 2 2 0 Radical SAM superfamily Ribul_P_3_epim PF00834.19 PIK46870.1 - 1.3e-16 60.6 0.0 1.4e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Myosin_head PF00063.21 PIK46871.1 - 9.1e-28 96.9 0.0 1.1e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_head PF00063.21 PIK46872.1 - 3.9e-63 213.8 0.4 5.1e-63 213.4 0.4 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF3137 PF11335.8 PIK46872.1 - 0.11 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3137) Myosin_head PF00063.21 PIK46873.1 - 3e-133 445.5 4.3 3e-133 445.5 4.3 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) IQ PF00612.27 PIK46873.1 - 7.7e-16 56.3 27.2 7.9e-06 25.2 4.4 5.5 5 0 0 5 5 5 4 IQ calmodulin-binding motif FlaC_arch PF05377.11 PIK46873.1 - 0.051 14.0 0.4 0.051 14.0 0.4 5.9 7 0 0 7 7 7 0 Flagella accessory protein C (FlaC) PhoU PF01895.19 PIK46873.1 - 3.8 8.0 14.2 0.95 10.0 2.4 4.5 2 1 3 5 5 5 0 PhoU domain ANF_receptor PF01094.28 PIK46874.1 - 3.2e-29 102.1 0.0 3.9e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Hamartin PF04388.12 PIK46875.1 - 0.74 8.4 7.1 0.87 8.2 7.1 1.1 1 0 0 1 1 1 0 Hamartin protein Acetyltransf_13 PF13880.6 PIK46876.1 - 1.5e-25 88.9 0.0 3.1e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 PIK46876.1 - 1.5e-17 63.1 0.2 2.7e-17 62.3 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 PIK46876.1 - 0.0073 16.5 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK46876.1 - 0.14 12.6 0.0 0.35 11.3 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Proteasome PF00227.26 PIK46879.1 - 7.3e-31 107.1 0.0 8.1e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit C2 PF00168.30 PIK46880.1 - 7e-07 29.5 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 C2 domain Paramecium_SA PF01508.16 PIK46880.1 - 0.62 10.5 7.0 3.1e+02 1.9 7.0 3.5 1 1 0 1 1 1 0 Paramecium surface antigen domain FerB PF08150.12 PIK46881.1 - 4.6e-31 107.3 0.0 8e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 FerB (NUC096) domain C2 PF00168.30 PIK46881.1 - 1.5e-09 38.1 0.0 3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK46882.1 - 2.8e-14 53.3 0.0 1.5e-13 50.9 0.0 2.0 2 0 0 2 2 2 1 C2 domain DND1_DSRM PF14709.7 PIK46882.1 - 0.18 12.1 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 Ferlin_C PF16165.5 PIK46883.1 - 1.1e-16 61.2 3.2 3.4e-10 40.1 0.1 2.1 1 1 1 2 2 2 2 Ferlin C-terminus XendoU PF09412.10 PIK46884.1 - 8e-42 143.3 4.2 6e-41 140.4 4.2 1.9 1 1 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK46884.1 - 8.7e-07 29.2 15.2 1.3e-06 28.7 15.2 1.3 1 0 0 1 1 1 1 Somatomedin B domain DUF2644 PF10841.8 PIK46884.1 - 0.095 12.9 0.1 0.26 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) WSC PF01822.19 PIK46885.1 - 4.3e-06 26.8 3.1 1e-05 25.7 3.1 1.6 1 0 0 1 1 1 1 WSC domain Endomucin PF07010.12 PIK46885.1 - 0.084 12.8 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Endomucin Laminin_EGF PF00053.24 PIK46886.1 - 1.3e-77 255.7 225.1 1.3e-11 44.4 13.4 12.9 11 1 1 12 12 12 12 Laminin EGF domain Laminin_N PF00055.17 PIK46886.1 - 1.5e-67 227.6 0.0 1.5e-67 227.6 0.0 3.5 4 0 0 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK46886.1 - 2.5e-19 69.5 0.0 5.5e-18 65.2 0.0 2.2 2 0 0 2 2 2 1 Laminin B (Domain IV) DUF295 PF03478.18 PIK46886.1 - 0.022 14.3 3.0 6.1 6.5 0.4 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF295) RE_MamI PF09567.10 PIK46886.1 - 0.041 13.5 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 MamI restriction endonuclease Laminin_G_2 PF02210.24 PIK46887.1 - 3e-87 289.6 0.2 2.1e-23 83.3 0.0 6.5 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.23 PIK46887.1 - 5.5e-84 278.9 0.0 3.4e-27 95.2 0.0 6.5 6 0 0 6 6 6 6 Laminin G domain Laminin_EGF PF00053.24 PIK46887.1 - 2.6e-23 81.9 71.4 2.4e-07 30.8 16.7 5.3 5 0 0 5 5 5 4 Laminin EGF domain Laminin_B PF00052.18 PIK46887.1 - 6.2e-11 42.3 0.0 2.1e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_G_3 PF13385.6 PIK46887.1 - 3.6e-10 40.2 0.0 0.025 14.7 0.0 5.2 5 0 0 5 5 5 3 Concanavalin A-like lectin/glucanases superfamily Laminin_II PF06009.12 PIK46887.1 - 4.8e-07 29.9 0.6 4.8e-07 29.9 0.6 3.8 4 0 0 4 4 4 1 Laminin Domain II E2R135 PF11570.8 PIK46887.1 - 0.063 13.6 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 PT PF04886.12 PIK46887.1 - 0.11 12.1 5.3 0.22 11.1 5.3 1.5 1 0 0 1 1 1 0 PT repeat DUF16 PF01519.16 PIK46887.1 - 0.32 11.5 2.2 1.8 9.1 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 Exonuc_VII_L PF02601.15 PIK46887.1 - 3.6 7.1 16.1 0.34 10.5 1.6 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit GIDA_assoc PF13932.6 PIK46887.1 - 8.7 6.5 11.0 0.12 12.5 1.6 2.3 2 1 0 2 2 2 0 GidA associated domain TPR_MLP1_2 PF07926.12 PIK46887.1 - 9.2 6.3 14.7 0.84 9.7 1.2 3.2 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DEAD PF00270.29 PIK46888.1 - 1.2e-44 152.2 0.0 2.9e-44 150.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK46888.1 - 2e-29 102.2 0.0 2.6e-28 98.6 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK46888.1 - 2.3e-06 27.7 0.9 1.6e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GUCT PF08152.12 PIK46888.1 - 6.4e-06 26.4 0.1 1.7e-05 25.0 0.1 1.8 1 0 0 1 1 1 1 GUCT (NUC152) domain CMS1 PF14617.6 PIK46888.1 - 0.00072 19.0 0.0 0.00072 19.0 0.0 3.2 2 1 1 3 3 3 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 PIK46888.1 - 0.0047 16.2 0.0 0.011 15.0 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase NACHT PF05729.12 PIK46890.1 - 1.3e-10 41.4 0.0 3.4e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK46890.1 - 0.00054 19.6 0.0 0.0015 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK46890.1 - 0.0021 18.3 0.0 0.0081 16.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK46890.1 - 0.11 12.9 0.0 0.54 10.7 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 PIK46890.1 - 0.17 11.9 0.0 0.61 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 PIK46892.1 - 1.2e-15 57.9 0.0 3.3e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK46892.1 - 0.0068 16.0 0.1 0.074 12.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK46892.1 - 0.033 14.6 0.0 0.89 10.0 0.0 2.9 3 0 0 3 3 3 0 RNA helicase RVT_1 PF00078.27 PIK46893.1 - 3.3e-08 33.3 0.0 4.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK46894.1 - 2.6e-30 104.4 0.0 3.8e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK46894.1 - 3.1e-27 94.9 0.0 4.3e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PSI_PsaJ PF01701.18 PIK46894.1 - 0.045 14.3 0.1 0.12 12.9 0.1 1.8 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ V-set PF07686.17 PIK46895.1 - 2.9e-10 40.3 1.4 0.0008 19.6 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK46895.1 - 2.2e-06 27.7 1.4 0.033 14.4 0.1 3.6 4 0 0 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK46895.1 - 2.6e-05 24.7 2.0 0.53 10.9 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK46895.1 - 0.0071 16.4 0.3 0.026 14.6 0.3 2.0 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK46895.1 - 0.012 15.9 2.2 5.8 7.3 0.0 3.8 2 2 3 5 5 5 0 Immunoglobulin domain C1-set PF07654.15 PIK46895.1 - 0.03 14.7 1.4 0.17 12.3 0.5 2.7 3 0 0 3 3 3 0 Immunoglobulin C1-set domain RVT_1 PF00078.27 PIK46897.1 - 3.7e-29 101.8 0.0 4.7e-29 101.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HeH PF12949.7 PIK46897.1 - 0.038 13.7 0.2 0.07 12.9 0.2 1.5 1 0 0 1 1 1 0 HeH/LEM domain NACHT PF05729.12 PIK46898.1 - 1.3e-10 41.5 0.0 2.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TPR_12 PF13424.6 PIK46898.1 - 2.3e-06 27.8 6.1 0.00019 21.7 0.2 4.8 5 1 1 6 6 6 2 Tetratricopeptide repeat AAA_16 PF13191.6 PIK46898.1 - 5.4e-06 26.9 0.0 5.1e-05 23.7 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 PIK46898.1 - 0.0051 16.5 0.1 0.009 15.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK46898.1 - 0.015 15.6 0.0 0.061 13.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 PIK46898.1 - 0.036 14.2 0.0 0.085 13.0 0.0 1.6 1 0 0 1 1 1 0 Torsin TPR_2 PF07719.17 PIK46898.1 - 0.037 14.1 2.3 2.3 8.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 PIK46898.1 - 0.038 14.2 0.0 28 5.2 0.0 3.8 3 0 0 3 3 3 0 PPR repeat AAA_19 PF13245.6 PIK46898.1 - 0.04 14.2 0.7 0.082 13.2 0.1 1.7 2 0 0 2 2 2 0 AAA domain TPR_10 PF13374.6 PIK46898.1 - 0.042 13.7 1.1 54 3.8 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK46898.1 - 0.084 12.7 6.6 0.52 10.2 0.1 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4062 PF13271.6 PIK46899.1 - 1.5e-12 47.7 0.0 5.1e-12 46.0 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4062) DUF3322 PF11795.8 PIK46899.1 - 0.06 13.4 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) MTES_1575 PF18741.1 PIK46899.1 - 0.13 12.5 0.1 0.36 11.0 0.1 1.8 2 0 0 2 2 2 0 REase_MTES_1575 Ig_3 PF13927.6 PIK46900.1 - 0.0005 20.6 0.1 0.11 13.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain hEGF PF12661.7 PIK46900.1 - 0.025 15.2 8.1 0.025 15.2 8.1 5.6 5 1 0 5 5 5 0 Human growth factor-like EGF ig PF00047.25 PIK46900.1 - 0.045 13.9 1.3 1.9 8.7 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin domain m04gp34like PF12216.8 PIK46900.1 - 0.047 13.3 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 Immune evasion protein Get5_bdg PF16843.5 PIK46902.1 - 0.17 11.4 0.4 0.92 9.1 0.0 2.3 3 0 0 3 3 3 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein Reprolysin PF01421.19 PIK46903.1 - 2.3e-56 190.9 0.0 2.3e-56 190.9 0.0 2.3 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 PIK46903.1 - 6.2e-24 84.8 0.1 1.4e-23 83.7 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.12 PIK46903.1 - 8.2e-21 74.6 5.6 8.2e-21 74.6 5.6 2.7 2 0 0 2 2 1 1 ADAM cysteine-rich Disintegrin PF00200.23 PIK46903.1 - 4.3e-18 65.9 29.3 4.3e-18 65.9 29.3 3.3 3 1 0 3 3 2 1 Disintegrin Reprolysin_5 PF13688.6 PIK46903.1 - 5.6e-17 62.5 0.6 1.3e-16 61.4 0.6 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK46903.1 - 3.3e-15 56.7 0.1 7e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK46903.1 - 1.6e-10 40.9 0.2 2.8e-10 40.2 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK46903.1 - 3.6e-10 40.0 0.7 7.2e-10 39.1 0.7 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK46903.1 - 0.0012 18.8 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Peptidase_M54 PF07998.11 PIK46903.1 - 0.019 15.0 1.4 0.038 14.0 1.4 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 PIK46903.1 - 0.027 13.4 0.5 0.051 12.5 0.5 1.3 1 0 0 1 1 1 0 Peptidase M66 DUF2268 PF10026.9 PIK46903.1 - 0.23 11.0 0.9 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Predicted Zn-dependent protease (DUF2268) zf-RING_2 PF13639.6 PIK46904.1 - 4.5e-09 36.5 12.9 4.5e-09 36.5 12.9 3.3 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 PIK46904.1 - 9.4e-08 31.7 5.6 9.4e-08 31.7 5.6 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK46904.1 - 0.0017 18.1 13.6 0.0017 18.1 13.6 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK46904.1 - 0.004 17.0 11.5 0.004 17.0 11.5 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK46904.1 - 0.0046 17.2 11.8 0.0046 17.2 11.8 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain NOA36 PF06524.12 PIK46906.1 - 7.8 5.7 7.0 11 5.3 7.0 1.1 1 0 0 1 1 1 0 NOA36 protein PP1_bind PF15276.6 PIK46907.1 - 3.5e-12 46.4 3.7 3.5e-12 46.4 3.7 4.8 2 1 0 2 2 2 1 Protein phosphatase 1 binding Transferrin PF00405.17 PIK46909.1 - 2.2e-115 385.4 4.9 2.1e-70 237.5 0.2 3.0 2 1 1 3 3 3 3 Transferrin Phosphonate-bd PF12974.7 PIK46909.1 - 2.1e-07 30.8 0.0 6.8e-06 25.9 0.0 2.9 2 1 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF247 PF03140.15 PIK46909.1 - 0.0057 15.9 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Plant protein of unknown function Transferrin PF00405.17 PIK46910.1 - 1.3e-40 139.6 5.2 8.6e-40 136.9 1.9 2.8 2 1 0 2 2 2 1 Transferrin Phosphonate-bd PF12974.7 PIK46910.1 - 0.00028 20.5 0.0 0.00044 19.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Fibrinogen_C PF00147.18 PIK46911.1 - 3e-57 194.0 6.9 3.7e-57 193.7 6.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK46912.1 - 1.5e-50 172.0 5.5 1.8e-50 171.8 5.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK46913.1 - 1.4e-55 188.5 3.3 1.9e-55 188.1 3.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Sec7 PF01369.20 PIK46914.1 - 6.2e-66 221.6 1.0 1.2e-65 220.7 1.0 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 PIK46914.1 - 3e-48 163.7 5.2 1.1e-47 161.9 4.8 2.2 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 PIK46914.1 - 2.1e-22 79.6 7.8 8.8e-15 54.8 1.8 2.8 1 1 1 2 2 2 2 Dimerisation and cyclophilin-binding domain of Mon2 FAM176 PF14851.6 PIK46914.1 - 0.051 13.2 3.7 3.6 7.3 2.1 2.5 2 0 0 2 2 2 0 FAM176 family MscS_TM PF12794.7 PIK46914.1 - 0.21 10.4 1.7 0.41 9.5 1.7 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 LRR_8 PF13855.6 PIK46915.1 - 7.5e-11 41.6 3.3 1.1e-10 41.1 3.3 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_5 PF13306.6 PIK46915.1 - 6.6e-05 22.9 0.4 0.00012 22.0 0.4 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK46915.1 - 0.0015 18.9 3.1 0.0015 18.9 3.1 2.4 2 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK46915.1 - 0.013 16.0 1.2 0.13 12.9 0.4 3.0 2 1 0 2 2 2 0 Leucine Rich Repeat BRCA2 PF00634.18 PIK46915.1 - 0.16 11.7 0.6 14 5.5 0.2 2.3 2 0 0 2 2 2 0 BRCA2 repeat SH2 PF00017.24 PIK46916.1 - 1.9e-06 27.9 0.1 5e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 SH2 domain Death PF00531.22 PIK46916.1 - 2.4e-06 27.6 0.1 6.1e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Death domain SAM_1 PF00536.30 PIK46918.1 - 1.1e-20 73.8 0.1 2.2e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK46918.1 - 5.5e-18 64.8 0.0 1.8e-17 63.2 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 PIK46918.1 - 5.9e-11 42.1 0.0 1.2e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Ank_2 PF12796.7 PIK46918.1 - 9.5e-08 32.5 0.0 2.6e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PDZ PF00595.24 PIK46918.1 - 1.8e-07 31.4 0.1 8.7e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Ank_4 PF13637.6 PIK46918.1 - 3.8e-07 30.5 0.2 1.8e-06 28.4 0.2 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK46918.1 - 4e-06 26.7 0.3 0.02 15.4 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 PIK46918.1 - 2.3e-05 24.6 0.6 0.012 16.0 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 PIK46918.1 - 7.1e-05 23.0 0.3 0.00022 21.5 0.3 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PDZ_2 PF13180.6 PIK46918.1 - 0.00026 21.2 0.0 0.00076 19.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain SAM_4 PF18017.1 PIK46918.1 - 0.00039 20.3 0.0 0.00076 19.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK46918.1 - 0.0042 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 PIK46918.1 - 0.0068 16.2 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 PIK46918.1 - 0.034 13.8 0.0 0.08 12.6 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 PIK46918.1 - 0.1 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 SH3 domain SAM_Ste50p PF09235.10 PIK46918.1 - 0.11 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif FERM_f0 PF16511.5 PIK46919.1 - 0.00012 22.3 0.0 0.00019 21.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM rve PF00665.26 PIK46921.1 - 6e-24 84.5 0.0 9.5e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46921.1 - 8.8e-11 41.8 0.9 1.7e-10 40.9 0.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK46921.1 - 0.0041 17.3 0.9 0.0081 16.4 0.9 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK46921.1 - 0.0044 16.8 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK46921.1 - 0.016 15.7 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal QueC PF06508.13 PIK46921.1 - 0.18 11.3 0.6 0.33 10.4 0.6 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC RVT_1 PF00078.27 PIK46922.1 - 8.7e-10 38.5 0.0 1.1e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WSK PF03832.13 PIK46922.1 - 8.3 6.2 5.7 1.7 8.4 0.4 2.2 2 0 0 2 2 2 0 WSK motif zf-CCHC PF00098.23 PIK46923.1 - 1e-07 31.7 1.9 2.3e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK46923.1 - 0.00036 20.3 0.1 0.00036 20.3 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK46923.1 - 0.13 12.0 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK46923.1 - 0.19 11.8 0.3 0.45 10.6 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK46923.1 - 0.24 11.2 0.5 0.5 10.1 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle NGF PF00243.18 PIK46925.1 - 0.0012 19.1 0.2 0.0019 18.4 0.2 1.4 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 PIK46925.1 - 0.0044 17.5 0.2 0.0067 16.9 0.2 1.4 1 0 0 1 1 1 1 Spaetzle Nucleos_tra2_C PF07662.13 PIK46926.1 - 1.9e-81 272.8 3.5 2.8e-81 272.3 3.5 1.2 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus CTK3_C PF12350.8 PIK46927.1 - 0.11 12.6 1.5 0.3 11.3 1.5 1.7 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 C-terminus RVT_1 PF00078.27 PIK46928.1 - 5e-30 104.7 0.0 1.1e-29 103.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK46928.1 - 7.3e-23 81.0 0.0 1.8e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK46928.1 - 1.5e-19 69.8 1.8 4.2e-19 68.4 1.8 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK46928.1 - 1.1e-11 45.0 0.0 3.2e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK46928.1 - 0.00016 21.6 0.1 0.00037 20.5 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK46928.1 - 0.00021 21.4 1.0 0.0013 18.9 0.9 2.3 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK46928.1 - 0.00069 19.3 0.7 0.002 17.8 0.2 2.2 2 0 0 2 2 2 1 Integrase core domain SprT-like PF10263.9 PIK46928.1 - 0.15 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 SprT-like family zf-CCHC_2 PF13696.6 PIK46929.1 - 9.8e-05 22.1 5.9 0.00022 21.0 5.9 1.6 1 0 0 1 1 1 1 Zinc knuckle PNMA PF14893.6 PIK46929.1 - 0.0037 16.7 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC_3 PF13917.6 PIK46929.1 - 0.0041 17.0 1.7 0.0078 16.2 1.7 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 PIK46929.1 - 0.007 16.8 0.4 0.015 15.7 0.4 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.23 PIK46929.1 - 0.029 14.5 5.8 0.044 13.9 5.8 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK46929.1 - 0.085 12.6 3.8 0.18 11.5 3.8 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Fez1 PF06818.15 PIK46929.1 - 0.16 12.4 1.4 8.2 6.8 0.1 2.6 2 1 0 2 2 2 0 Fez1 DUF2717 PF10911.8 PIK46929.1 - 0.17 11.6 0.0 0.49 10.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) VWA_3 PF13768.6 PIK46930.1 - 2.1e-14 53.7 0.0 3.4e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK46930.1 - 4e-09 37.0 0.0 8.2e-09 35.9 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK46930.1 - 0.00073 20.2 0.0 0.0019 18.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain SPT2 PF08243.11 PIK46931.1 - 1.2e-23 83.8 13.2 1.6e-23 83.3 13.2 1.2 1 0 0 1 1 1 1 SPT2 chromatin protein Sigma70_r3 PF04539.16 PIK46931.1 - 0.025 14.7 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 Sigma-70 region 3 SOTI PF17079.5 PIK46932.1 - 0.031 14.7 0.3 0.093 13.1 0.3 1.9 1 0 0 1 1 1 0 Male-specific protein scotti DUF2045 PF09741.9 PIK46933.1 - 1.1e-75 254.0 0.2 1.8e-75 253.3 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) Guanylate_cyc PF00211.20 PIK46935.1 - 1.5e-56 191.0 0.0 2.1e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 PIK46935.1 - 6.1e-15 55.3 0.6 6.1e-15 55.3 0.6 2.9 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 PIK46935.1 - 7.6e-08 32.8 0.3 5.4e-07 30.1 0.3 2.2 1 1 0 1 1 1 1 Domain of Unknown Function (DUF1053) Phage_coat PF09063.10 PIK46935.1 - 0.17 11.9 0.1 0.37 10.8 0.1 1.5 1 0 0 1 1 1 0 Phage PP7 coat protein MscS_TM PF12794.7 PIK46935.1 - 0.88 8.4 10.3 0.18 10.6 0.3 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Guanylate_cyc PF00211.20 PIK46936.1 - 6.7e-38 130.1 0.3 7.4e-38 130.0 0.3 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain UPF0086 PF01868.16 PIK46937.1 - 7.7e-26 89.8 0.1 1.2e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Molybdop_Fe4S4 PF04879.16 PIK46937.1 - 0.084 12.9 0.5 0.15 12.0 0.5 1.5 1 1 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain Metallophos PF00149.28 PIK46938.1 - 8.2e-19 68.9 3.0 1.3e-18 68.2 0.2 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 PIK46938.1 - 1.6e-18 67.1 0.0 3.1e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 PIK46938.1 - 5.3e-15 56.0 0.0 1.6e-14 54.5 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD_N PF16655.5 PIK46938.1 - 0.0034 17.9 0.1 0.0098 16.4 0.0 1.8 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain Metallophos_2 PF12850.7 PIK46938.1 - 0.0062 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain IRF PF00605.17 PIK46939.1 - 9.3e-38 128.7 0.1 1.9e-37 127.7 0.1 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IRF-3 PF10401.9 PIK46939.1 - 1.7e-19 70.3 0.0 3e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MH2 PF03166.14 PIK46939.1 - 0.052 13.8 0.1 0.095 12.9 0.1 1.4 1 0 0 1 1 1 0 MH2 domain DUF4638 PF15472.6 PIK46940.1 - 4.6e-10 39.7 0.1 9.8e-10 38.6 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4638) EamA PF00892.20 PIK46942.1 - 1.7e-17 63.8 22.3 1.5e-13 51.1 11.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF1129 PF06570.11 PIK46942.1 - 1.2 8.6 4.4 1.2 8.6 3.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Acyl_transf_3 PF01757.22 PIK46943.1 - 7.2e-18 64.7 35.2 1.1e-17 64.1 35.2 1.2 1 0 0 1 1 1 1 Acyltransferase family Piezo_RRas_bdg PF12166.8 PIK46945.1 - 9.9e-86 288.7 0.0 1.3e-47 163.1 0.1 2.6 1 1 1 2 2 2 2 Piezo non-specific cation channel, R-Ras-binding domain SpoIIIAH PF12685.7 PIK46945.1 - 0.0011 18.8 16.8 0.0011 18.8 16.8 2.9 3 0 0 3 3 3 1 SpoIIIAH-like protein Zip PF02535.22 PIK46945.1 - 0.0025 17.1 0.5 0.0025 17.1 0.5 2.0 2 0 0 2 2 2 1 ZIP Zinc transporter PIEZO PF15917.5 PIK46945.1 - 0.015 14.8 0.0 0.015 14.8 0.0 3.6 3 1 0 3 3 3 0 Piezo TMEM247 PF15444.6 PIK46945.1 - 0.075 13.1 7.8 0.21 11.6 7.8 1.7 1 0 0 1 1 1 0 Transmembrane protein 247 DUF4407 PF14362.6 PIK46945.1 - 3.3 7.0 12.6 9.3 5.5 12.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) tRNA-synt_1b PF00579.25 PIK46946.1 - 1.5e-67 228.0 0.1 2.8e-67 227.1 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.20 PIK46946.1 - 9.9e-30 102.5 0.0 3e-29 101.0 0.0 1.9 2 0 0 2 2 2 1 Putative tRNA binding domain Phage_TAC_5 PF08890.11 PIK46947.1 - 0.015 15.3 0.6 0.015 15.3 0.6 2.9 3 0 0 3 3 3 0 Phage XkdN-like tail assembly chaperone protein, TAC LisH_TPL PF17814.1 PIK46947.1 - 0.091 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 LisH-like dimerisation domain Forkhead PF00250.18 PIK46948.1 - 5.7e-26 90.6 0.0 1.2e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain FOXO-TAD PF16676.5 PIK46948.1 - 0.061 13.7 0.2 0.13 12.7 0.2 1.5 1 0 0 1 1 1 0 Transactivation domain of FOXO protein family MFS_1 PF07690.16 PIK46949.1 - 7.6e-06 25.1 5.7 9.9e-06 24.7 5.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3429 PF11911.8 PIK46949.1 - 0.0095 16.2 0.6 0.016 15.5 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) PRA1 PF03208.19 PIK46949.1 - 5 6.7 7.5 12 5.5 7.5 1.9 1 1 0 1 1 1 0 PRA1 family protein MFS_1 PF07690.16 PIK46950.1 - 8.5e-10 38.1 10.4 9.7e-10 37.9 10.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Hormone_2 PF00123.20 PIK46953.1 - 0.23 11.4 0.5 7 6.6 0.1 2.5 2 0 0 2 2 2 0 Peptide hormone MFS_1 PF07690.16 PIK46954.1 - 5.1e-10 38.8 3.2 6.1e-10 38.5 3.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK46954.1 - 1.7e-09 37.1 6.1 2.2e-09 36.7 6.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Aa_trans PF01490.18 PIK46954.1 - 0.0017 17.1 1.8 0.0017 17.1 1.8 1.5 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Peptidase_U4 PF03419.13 PIK46954.1 - 1.1 8.5 6.3 1.5 8.1 6.3 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA LSM PF01423.22 PIK46956.1 - 1.2e-12 47.3 0.2 1.9e-12 46.7 0.2 1.3 1 0 0 1 1 1 1 LSM domain DUF5101 PF17031.5 PIK46956.1 - 0.031 14.4 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) SM-ATX PF14438.6 PIK46956.1 - 0.095 12.9 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain TPR_2 PF07719.17 PIK46957.1 - 0.0017 18.3 0.3 13 6.2 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK46957.1 - 0.094 13.0 0.3 5.9 7.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 PIK46958.1 - 7.6e-08 31.7 2.8 8.8e-08 31.4 2.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK46958.1 - 0.00071 18.6 0.7 0.00082 18.3 0.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter VHS PF00790.19 PIK46959.1 - 3.6e-38 130.6 0.7 7.8e-38 129.5 0.0 1.8 2 0 0 2 2 2 1 VHS domain GGA_N-GAT PF18308.1 PIK46959.1 - 3.8e-20 71.2 7.1 1.4e-19 69.4 7.1 2.1 1 0 0 1 1 1 1 GGA N-GAT domain GAT PF03127.14 PIK46959.1 - 2.9e-17 62.7 0.2 2.9e-17 62.7 0.2 2.5 2 0 0 2 2 2 1 GAT domain Alpha_adaptinC2 PF02883.20 PIK46959.1 - 9e-16 58.2 1.0 4.6e-15 55.9 0.3 2.2 2 0 0 2 2 2 1 Adaptin C-terminal domain FliT PF05400.13 PIK46959.1 - 0.87 10.4 4.0 2.8 8.8 0.1 3.0 3 1 0 3 3 3 0 Flagellar protein FliT SHMT PF00464.19 PIK46960.1 - 1.1e-193 643.3 0.0 1.3e-193 643.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 PIK46960.1 - 0.00076 18.8 0.0 0.0014 17.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Gp-FAR-1 PF05823.12 PIK46960.1 - 0.073 13.4 0.5 16 5.9 0.1 2.5 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1104 PF06518.11 PIK46960.1 - 0.12 12.7 1.5 0.46 10.9 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) DUF1759 PF03564.15 PIK46961.1 - 3.5e-06 27.0 0.4 8.6e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Paired_CXXCH_1 PF09699.10 PIK46964.1 - 0.052 13.3 0.1 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 PIK46964.1 - 3.2 7.8 5.7 14 5.8 5.7 1.9 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c TMEM100 PF16311.5 PIK46966.1 - 0.012 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 100 CtaG_Cox11 PF04442.14 PIK46968.1 - 9.7e-49 165.3 1.1 1.1e-48 165.1 1.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Thioredoxin PF00085.20 PIK46969.1 - 2.2e-29 101.5 0.1 2.6e-29 101.3 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 PIK46969.1 - 1.4e-09 38.3 0.0 6.3e-08 33.0 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK46969.1 - 3.8e-07 30.3 0.1 1.7e-05 25.1 0.0 2.4 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 PIK46969.1 - 1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 PIK46969.1 - 2.2e-05 24.2 0.0 2.7e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 PIK46969.1 - 2.9e-05 23.8 0.1 3.7e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 AhpC-TSA PF00578.21 PIK46969.1 - 3.7e-05 23.6 0.1 4.5e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_3 PF13192.6 PIK46969.1 - 0.00013 21.9 0.0 0.00022 21.2 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin domain OST3_OST6 PF04756.13 PIK46969.1 - 0.00026 20.4 0.1 0.00054 19.4 0.0 1.5 1 1 1 2 2 2 1 OST3 / OST6 family, transporter family HyaE PF07449.11 PIK46969.1 - 0.0012 18.8 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE DUF836 PF05768.14 PIK46969.1 - 0.0022 18.4 0.0 0.0033 17.8 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DUF953 PF06110.11 PIK46969.1 - 0.01 15.5 0.1 0.029 14.0 0.1 1.9 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) DSBA PF01323.20 PIK46969.1 - 0.015 15.1 0.0 0.36 10.6 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Glutaredoxin PF00462.24 PIK46969.1 - 0.017 15.3 0.1 0.034 14.4 0.1 1.5 1 1 0 1 1 1 0 Glutaredoxin Thioredoxin_6 PF13848.6 PIK46969.1 - 0.024 14.5 0.1 0.21 11.5 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_5 PF13743.6 PIK46969.1 - 0.068 12.8 0.3 0.86 9.3 0.1 2.3 2 1 1 3 3 3 0 Thioredoxin Xan_ur_permease PF00860.20 PIK46970.1 - 3.6e-19 68.7 4.1 7.5e-18 64.4 4.5 2.0 2 0 0 2 2 2 2 Permease family DUF2157 PF09925.9 PIK46970.1 - 0.4 10.5 2.3 0.72 9.6 2.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) MFS_MOT1 PF16983.5 PIK46970.1 - 0.7 10.3 4.4 0.41 11.1 2.0 1.8 1 1 1 2 2 2 0 Molybdate transporter of MFS superfamily Xan_ur_permease PF00860.20 PIK46971.1 - 3.8e-39 134.5 9.7 5.1e-39 134.1 9.7 1.2 1 0 0 1 1 1 1 Permease family DUF2232 PF09991.9 PIK46971.1 - 2.8e-05 23.4 2.7 3.9e-05 23.0 2.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) Peptidase_M50 PF02163.22 PIK46971.1 - 0.09 12.0 0.7 0.14 11.4 0.5 1.3 1 1 0 1 1 1 0 Peptidase family M50 Macoilin PF09726.9 PIK46972.1 - 0.14 10.7 1.4 0.21 10.1 1.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF755 PF05501.11 PIK46972.1 - 2.3 8.5 8.8 6.6 7.0 8.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SelP_N PF04592.14 PIK46972.1 - 5.5 6.3 11.0 10 5.5 11.0 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Hexapep PF00132.24 PIK46973.1 - 1e-13 50.4 17.4 1.5e-06 27.6 0.8 4.7 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 PIK46973.1 - 2.3e-07 30.4 15.0 0.00019 21.1 0.8 4.0 4 0 0 4 4 4 3 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 PIK46973.1 - 0.0065 14.7 1.2 0.012 13.8 0.5 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 PIK46973.1 - 0.14 11.0 2.8 0.51 9.2 2.8 1.8 1 1 0 1 1 1 0 L-fucokinase ParA PF10609.9 PIK46974.1 - 4.3e-100 334.2 0.0 5.1e-100 334.0 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 PIK46974.1 - 2.5e-10 40.5 0.0 3.3e-09 36.9 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 PIK46974.1 - 3.2e-07 30.4 0.5 4.2e-06 26.8 0.5 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 PIK46974.1 - 0.00019 20.7 1.6 0.0012 18.1 0.1 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 PIK46974.1 - 0.0042 17.0 0.3 0.011 15.6 0.1 1.7 2 0 0 2 2 2 1 RsgA GTPase Fer4_NifH PF00142.18 PIK46974.1 - 0.0064 16.0 0.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.15 PIK46974.1 - 0.0085 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_26 PF13500.6 PIK46974.1 - 0.0088 15.9 0.2 1.7 8.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 PIK46974.1 - 0.011 15.0 0.2 0.033 13.5 0.2 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.6 PIK46974.1 - 0.014 15.8 0.1 0.027 14.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 PIK46974.1 - 0.019 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 PIK46974.1 - 0.053 12.7 0.1 0.084 12.0 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 PIK46974.1 - 0.055 14.0 0.0 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain CLP1_P PF16575.5 PIK46974.1 - 0.067 13.0 0.7 0.75 9.6 0.1 2.4 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop TsaE PF02367.17 PIK46974.1 - 0.083 12.9 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CBP_BcsQ PF06564.12 PIK46974.1 - 0.089 12.3 0.1 0.37 10.2 0.1 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 PIK46974.1 - 0.14 11.1 0.2 0.21 10.6 0.2 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 PIK46974.1 - 0.2 10.9 0.0 0.33 10.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 PIK46974.1 - 0.27 11.3 0.6 0.48 10.5 0.6 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain DUF846 PF05832.12 PIK46975.1 - 5.1e-36 123.8 0.8 7.7e-36 123.2 0.8 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF2079 PF09852.9 PIK46975.1 - 0.003 16.5 0.2 0.0035 16.2 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2079) DUF1601 PF07671.11 PIK46975.1 - 0.07 13.0 0.1 0.21 11.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1601) DNA_ligase_A_M PF01068.21 PIK46976.1 - 6.5e-64 215.3 1.7 1.1e-63 214.6 0.5 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 PIK46976.1 - 4.3e-38 131.3 0.2 9.7e-38 130.2 0.0 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 PIK46976.1 - 5.6e-16 59.0 0.0 2.5e-15 56.8 0.0 2.2 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 PIK46976.1 - 0.00011 22.6 0.1 0.00044 20.6 0.1 2.0 2 0 0 2 2 2 1 RNA ligase PuR_N PF09182.10 PIK46976.1 - 0.14 12.2 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal BTG PF07742.12 PIK46977.1 - 1.4e-35 121.6 0.0 2e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 BTG family BTG PF07742.12 PIK46978.1 - 2.8e-35 120.6 0.0 4.4e-35 120.0 0.0 1.3 1 0 0 1 1 1 1 BTG family Baculo_PEP_C PF04513.12 PIK46979.1 - 0.0033 17.5 2.5 0.0034 17.4 1.4 1.4 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus MIS13 PF08202.11 PIK46979.1 - 0.0066 15.8 5.8 0.0081 15.5 5.8 1.1 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Spc29 PF17082.5 PIK46979.1 - 0.0096 15.8 5.1 0.013 15.4 5.1 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 MbeD_MobD PF04899.12 PIK46979.1 - 0.015 15.4 1.0 0.047 13.8 0.0 2.1 2 0 0 2 2 2 0 MbeD/MobD like Fib_alpha PF08702.10 PIK46979.1 - 0.019 15.1 1.9 0.019 15.1 1.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 PIK46979.1 - 0.024 14.7 5.3 0.064 13.3 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 PIK46979.1 - 0.026 14.5 7.9 0.041 13.9 7.9 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 PIK46979.1 - 0.035 13.9 2.0 0.069 12.9 2.0 1.6 1 0 0 1 1 1 0 Septum formation initiator Laminin_II PF06009.12 PIK46979.1 - 0.043 13.8 5.6 0.025 14.6 3.5 1.6 1 1 1 2 2 2 0 Laminin Domain II Prominin PF05478.11 PIK46979.1 - 0.054 11.5 5.5 0.067 11.1 5.5 1.0 1 0 0 1 1 1 0 Prominin Jnk-SapK_ap_N PF09744.9 PIK46979.1 - 0.054 13.7 8.1 0.049 13.9 6.9 1.5 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 PIK46979.1 - 0.074 11.9 7.0 0.11 11.4 7.0 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Hemagglutinin PF00509.18 PIK46979.1 - 0.11 10.8 2.7 0.13 10.6 2.7 1.1 1 0 0 1 1 1 0 Haemagglutinin TSNAXIP1_N PF15739.5 PIK46979.1 - 0.14 12.5 5.1 0.13 12.6 3.8 1.6 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus Syntaxin-6_N PF09177.11 PIK46979.1 - 0.16 12.6 11.1 5.8 7.5 11.1 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Phage_GPO PF05929.11 PIK46979.1 - 0.16 11.5 5.6 0.21 11.1 5.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase SlyX PF04102.12 PIK46979.1 - 0.17 12.6 3.0 0.23 12.1 0.6 2.4 1 1 2 3 3 3 0 SlyX Sipho_Gp157 PF05565.11 PIK46979.1 - 0.19 11.7 5.0 0.21 11.6 4.1 1.4 1 1 0 1 1 1 0 Siphovirus Gp157 DUF948 PF06103.11 PIK46979.1 - 0.23 11.7 1.3 0.52 10.6 1.3 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Snapin_Pallidin PF14712.6 PIK46979.1 - 0.32 11.4 9.6 2.2 8.7 1.9 2.1 1 1 1 2 2 2 0 Snapin/Pallidin Fzo_mitofusin PF04799.13 PIK46979.1 - 0.37 10.3 5.2 0.33 10.5 3.1 1.7 1 1 0 1 1 1 0 fzo-like conserved region Cortex-I_coil PF09304.10 PIK46979.1 - 0.61 10.3 9.2 1.9 8.7 2.6 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil Exonuc_VII_L PF02601.15 PIK46979.1 - 0.91 9.0 8.6 1.2 8.6 8.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3450 PF11932.8 PIK46979.1 - 1 8.6 7.9 0.27 10.5 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HAUS6_N PF14661.6 PIK46979.1 - 1.8 8.1 7.1 2.4 7.7 7.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CENP-H PF05837.12 PIK46979.1 - 2 8.8 11.3 3.8 8.0 4.4 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) XhlA PF10779.9 PIK46979.1 - 3.3 8.0 9.6 1.9 8.8 2.4 2.6 1 1 3 4 4 4 0 Haemolysin XhlA WD40 PF00400.32 PIK46980.1 - 1.8e-13 50.7 1.8 9.9e-05 23.0 0.0 5.9 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK46980.1 - 2.6e-09 37.2 0.1 0.44 10.9 0.0 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Kelch_1 PF01344.25 PIK46980.1 - 0.28 10.8 2.2 22 4.7 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Aminotran_1_2 PF00155.21 PIK46981.1 - 8.5e-27 94.3 0.0 1e-26 94.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 PIK46981.1 - 0.00038 19.8 0.0 0.0007 19.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 PIK46981.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme RGM_N PF06535.12 PIK46983.1 - 9.7e-06 25.9 9.7 0.0091 16.2 2.2 2.2 1 1 1 2 2 2 2 Repulsive guidance molecule (RGM) N-terminus EF-hand_6 PF13405.6 PIK46983.1 - 1e-05 25.1 1.5 0.019 14.9 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK46983.1 - 0.00039 19.8 0.5 0.53 10.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK46983.1 - 0.00054 20.4 2.3 0.011 16.1 1.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair CPG4 PF15481.6 PIK46983.1 - 0.00061 20.4 9.5 0.062 13.9 1.2 2.5 2 0 0 2 2 2 2 Chondroitin proteoglycan 4 EF-hand_5 PF13202.6 PIK46983.1 - 0.0016 17.8 0.9 0.26 10.8 0.0 2.4 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 PIK46983.1 - 0.069 13.5 6.7 0.086 13.2 3.0 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF627 PF04781.12 PIK46983.1 - 0.16 12.0 1.8 12 6.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF627) NRN1 PF15056.6 PIK46983.1 - 0.21 11.7 6.8 3.4 7.8 0.5 2.8 2 1 1 3 3 3 0 Neuritin protein family ABC_tran_2 PF16949.5 PIK46984.1 - 0.1 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-binding cassette WSC PF01822.19 PIK46984.1 - 2.7 8.2 8.5 1.4 9.2 2.2 2.9 3 0 0 3 3 3 0 WSC domain WSC PF01822.19 PIK46986.1 - 3e-16 59.4 19.5 3.6e-09 36.7 7.1 2.3 2 0 0 2 2 2 2 WSC domain ABC_tran_2 PF16949.5 PIK46986.1 - 0.087 11.6 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Putative ATP-binding cassette Rubredoxin PF00301.20 PIK46987.1 - 0.031 14.3 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin Gly_radical PF01228.21 PIK46987.1 - 0.045 14.3 0.0 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 Glycine radical Peptidase_S9_N PF02897.15 PIK46987.1 - 0.13 11.0 0.0 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain AvrD PF05655.11 PIK46988.1 - 0.022 14.1 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) QueH PF02677.14 PIK46989.1 - 0.0005 20.2 1.2 0.00061 19.9 1.2 1.1 1 0 0 1 1 1 1 Epoxyqueuosine reductase QueH Ribosomal_L34e PF01199.18 PIK46989.1 - 0.029 14.7 3.6 0.084 13.2 3.9 1.6 2 0 0 2 2 2 0 Ribosomal protein L34e Trp_repressor PF01371.19 PIK46989.1 - 0.091 12.9 0.1 0.24 11.6 0.1 1.7 1 0 0 1 1 1 0 Trp repressor protein ADH_N_2 PF16884.5 PIK46990.1 - 3.1e-30 104.3 0.1 5.1e-30 103.6 0.1 1.4 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase Fibrinogen_C PF00147.18 PIK46991.1 - 6e-48 163.6 9.9 7.6e-48 163.2 9.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46991.1 - 0.00042 20.4 6.3 0.00042 20.4 6.3 2.9 3 0 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK46992.1 - 1e-56 192.2 11.3 1.3e-56 191.8 11.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK46992.1 - 0.06 13.6 3.0 0.06 13.6 3.0 3.0 3 0 0 3 3 3 0 EGF domain Pep1_7 PF17232.2 PIK46993.1 - 0.045 14.2 2.4 0.045 14.2 2.4 1.9 2 0 0 2 2 2 0 Elicitor peptide 1-7 Exotox-A_target PF09102.10 PIK46993.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Exotoxin A, targeting Pep1_7 PF17232.2 PIK46994.1 - 0.006 17.0 1.2 0.013 15.9 1.2 1.5 1 0 0 1 1 1 1 Elicitor peptide 1-7 Exotox-A_target PF09102.10 PIK46994.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A, targeting ABC_tran_2 PF16949.5 PIK46994.1 - 0.11 11.2 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-binding cassette Fibrinogen_C PF00147.18 PIK46995.1 - 1e-42 146.4 5.5 1.4e-42 146.0 5.5 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK46995.1 - 0.0022 17.9 0.2 0.0022 17.9 0.2 2.1 2 0 0 2 2 2 1 TILa domain Hex_IIIa PF02455.16 PIK46995.1 - 3.2 6.4 7.3 28 3.3 0.1 3.6 1 1 3 4 4 4 0 Hexon-associated protein (IIIa) RVT_1 PF00078.27 PIK46996.1 - 5.3e-19 68.6 0.1 7.5e-19 68.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exotox-A_target PF09102.10 PIK46996.1 - 0.1 12.6 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 Exotoxin A, targeting Fibrinogen_C PF00147.18 PIK46997.1 - 2.5e-36 125.5 2.7 3e-36 125.3 2.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain p450 PF00067.22 PIK46998.1 - 1.6e-115 386.5 0.0 2e-115 386.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C2 PF00648.21 PIK46999.1 - 3.2e-104 348.1 0.2 3.9e-104 347.8 0.2 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease DUF677 PF05055.12 PIK46999.1 - 0.031 13.2 0.2 0.041 12.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) BCS1_N PF08740.11 PIK47000.1 - 1.2e-44 152.6 1.3 1.7e-44 152.1 1.3 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 PIK47000.1 - 1e-19 71.3 0.0 1.9e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK47000.1 - 0.00035 20.9 0.0 0.0011 19.3 0.0 1.9 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 PIK47000.1 - 0.00055 19.9 0.0 0.0014 18.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 PIK47000.1 - 0.001 19.0 0.2 0.027 14.4 0.0 2.2 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 PIK47000.1 - 0.0018 18.7 0.0 0.013 15.9 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 PIK47000.1 - 0.0044 17.5 0.0 0.012 16.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 PIK47000.1 - 0.0046 17.1 0.0 0.016 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK47000.1 - 0.006 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 PIK47000.1 - 0.0077 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 PIK47000.1 - 0.036 13.8 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK47000.1 - 0.07 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 PIK47000.1 - 0.12 12.4 0.0 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK47000.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Glyco_transf_22 PF03901.17 PIK47001.1 - 9.3e-17 61.3 4.0 1.2e-16 61.0 4.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.17 PIK47002.1 - 5.2e-14 52.3 0.5 5.4e-14 52.2 0.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Methyltransf_3 PF01596.17 PIK47003.1 - 3.9e-32 111.1 0.0 4.4e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 PIK47003.1 - 1.7e-09 38.6 0.0 2.4e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK47003.1 - 1e-07 32.5 0.0 1.6e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK47003.1 - 1.8e-07 31.1 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK47003.1 - 0.00047 20.0 0.0 0.00064 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 PIK47003.1 - 0.00071 20.2 0.0 0.00098 19.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 PIK47003.1 - 0.00076 19.2 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Cons_hypoth95 PF03602.15 PIK47003.1 - 0.0028 17.3 0.0 0.0036 17.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Spermine_synth PF01564.17 PIK47003.1 - 0.0065 15.9 0.1 0.0077 15.7 0.1 1.3 1 1 0 1 1 1 1 Spermine/spermidine synthase domain DUF1188 PF06690.11 PIK47003.1 - 0.0077 15.8 0.0 0.0087 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) Methyltransf_32 PF13679.6 PIK47003.1 - 0.013 15.5 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 PIK47003.1 - 0.014 16.2 0.0 0.021 15.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 PIK47003.1 - 0.071 12.4 0.1 0.071 12.4 0.1 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 PIK47003.1 - 0.11 11.4 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GTP_EFTU PF00009.27 PIK47004.1 - 1.7e-62 210.4 0.2 4.1e-62 209.2 0.2 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 PIK47004.1 - 1.9e-30 104.7 0.0 3.7e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 PIK47004.1 - 1e-15 57.6 0.0 2.2e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 PIK47004.1 - 1.8e-14 53.8 0.0 4.6e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 PIK47004.1 - 4.3e-08 33.1 0.0 1.9e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 PIK47004.1 - 0.0018 18.7 0.0 0.22 12.1 0.0 2.6 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 PIK47004.1 - 0.0048 17.0 0.1 0.0097 16.0 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Sex_peptide PF08138.11 PIK47004.1 - 0.031 14.4 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 Sex peptide (SP) family AIG1 PF04548.16 PIK47004.1 - 0.039 13.3 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 AIG1 family DUF442 PF04273.13 PIK47004.1 - 0.068 13.3 0.0 12 6.1 0.0 2.4 2 0 0 2 2 2 0 Putative phosphatase (DUF442) FeoB_N PF02421.18 PIK47004.1 - 0.13 11.8 0.2 0.67 9.5 0.1 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B DUF3752 PF12572.8 PIK47005.1 - 3.5e-26 92.5 18.9 3.5e-26 92.5 18.9 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3752) ig PF00047.25 PIK47008.1 - 0.0013 18.8 0.2 0.0057 16.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.6 PIK47008.1 - 0.0034 17.3 2.1 0.0076 16.2 2.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 PIK47008.1 - 0.0085 16.7 0.0 0.055 14.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK47008.1 - 0.017 15.4 0.1 0.098 13.0 0.0 2.3 3 1 0 3 3 3 0 Immunoglobulin domain TMEM154 PF15102.6 PIK47009.1 - 0.004 17.1 1.3 0.0075 16.2 1.3 1.5 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 PIK47009.1 - 0.03 14.6 0.1 0.051 13.8 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ig PF00047.25 PIK47010.1 - 9.9e-05 22.5 0.1 0.00029 20.9 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK47010.1 - 0.0014 19.2 0.1 0.0074 16.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK47010.1 - 0.0034 17.7 0.0 0.015 15.6 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain TMEM154 PF15102.6 PIK47010.1 - 0.0037 17.2 2.4 0.0087 16.0 2.4 1.7 1 0 0 1 1 1 1 TMEM154 protein family I-set PF07679.16 PIK47010.1 - 0.011 15.8 0.1 0.059 13.4 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin I-set domain EGF PF00008.27 PIK47011.1 - 5.4e-06 26.6 20.4 8.9e-05 22.7 4.9 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.15 PIK47011.1 - 0.0013 18.9 5.3 0.0013 18.9 5.3 3.0 3 0 0 3 3 3 1 Calcium-binding EGF domain EGF_3 PF12947.7 PIK47011.1 - 0.0028 17.8 19.0 0.034 14.3 4.3 2.6 2 0 0 2 2 2 2 EGF domain cEGF PF12662.7 PIK47011.1 - 0.0069 16.3 12.4 0.45 10.5 2.7 3.2 2 0 0 2 2 2 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK47011.1 - 0.25 11.7 19.6 0.19 12.0 8.3 2.7 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site DUF3844 PF12955.7 PIK47011.1 - 0.71 10.0 8.3 3 8.0 7.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) SRCR PF00530.18 PIK47012.1 - 4.9e-17 62.3 0.2 8.8e-17 61.5 0.2 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47012.1 - 0.00057 20.4 0.1 0.0016 19.0 0.1 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Sybindin PF04099.12 PIK47013.1 - 7.4e-57 191.3 0.0 8.5e-57 191.1 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 PIK47013.1 - 5.2e-09 36.3 0.0 8.5e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PDZ_6 PF17820.1 PIK47013.1 - 0.0002 21.1 0.3 0.00036 20.3 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK47013.1 - 0.013 15.8 0.1 0.029 14.7 0.1 1.5 1 0 0 1 1 1 0 PDZ domain WD40 PF00400.32 PIK47014.1 - 7.9e-07 29.7 4.0 0.015 16.2 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat A_deamin PF02137.18 PIK47015.1 - 2e-49 168.8 0.7 1.8e-34 119.7 0.0 2.1 1 1 1 2 2 2 2 Adenosine-deaminase (editase) domain EF-hand_8 PF13833.6 PIK47016.1 - 2.8e-10 39.9 0.7 8.7e-05 22.3 0.4 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK47016.1 - 4.4e-10 38.4 0.4 0.0013 18.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK47016.1 - 1.1e-09 38.7 7.3 4.1e-08 33.5 0.7 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK47016.1 - 1e-08 34.4 0.5 0.0027 17.5 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK47016.1 - 5.3e-07 28.8 1.3 0.039 13.5 1.0 2.8 2 0 0 2 2 2 2 EF hand DUF641 PF04859.12 PIK47016.1 - 0.051 13.9 30.7 0.2 12.0 2.2 4.0 1 1 0 3 3 3 0 Plant protein of unknown function (DUF641) SPARC_Ca_bdg PF10591.9 PIK47016.1 - 0.66 10.3 0.1 0.66 10.3 0.1 3.8 2 1 0 2 2 1 0 Secreted protein acidic and rich in cysteine Ca binding region Spc7 PF08317.11 PIK47016.1 - 0.96 8.3 43.0 2.1 7.2 21.7 2.8 1 1 2 3 3 3 0 Spc7 kinetochore protein CENP-Q PF13094.6 PIK47016.1 - 1 9.5 31.1 2.6 8.2 20.7 2.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DASH_Dam1 PF08653.10 PIK47016.1 - 1.2 9.0 11.6 34 4.3 0.0 4.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 Jnk-SapK_ap_N PF09744.9 PIK47016.1 - 2.4 8.3 48.0 0.53 10.5 15.9 3.7 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 PXA PF02194.15 PIK47016.1 - 3.3 7.7 18.5 9.9e+02 -0.4 18.4 2.7 1 1 0 1 1 1 0 PXA domain KASH_CCD PF14662.6 PIK47016.1 - 3.5 7.4 44.3 1.1 9.0 5.2 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 PIK47016.1 - 5.5 6.7 45.9 8.7 6.1 42.2 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4201 PF13870.6 PIK47016.1 - 6.2 6.5 40.4 0.043 13.5 21.5 3.5 1 1 1 3 3 3 0 Domain of unknown function (DUF4201) DASH_Duo1 PF08651.10 PIK47016.1 - 7.2 6.5 16.7 0.38 10.6 1.4 4.1 4 0 0 4 4 4 0 DASH complex subunit Duo1 Ras PF00071.22 PIK47017.1 - 1.4e-25 89.8 0.0 1.5e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK47017.1 - 2.2e-17 63.4 0.0 2.5e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK47017.1 - 5e-10 39.1 0.0 5.5e-10 39.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK47017.1 - 9.2e-05 22.1 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK47017.1 - 0.014 15.4 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 PIK47018.1 - 1e-15 58.1 0.0 2.2e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK47018.1 - 9.4e-06 25.6 0.9 0.032 14.3 0.1 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK47018.1 - 1.7e-05 24.9 1.9 0.082 13.1 0.2 3.7 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK47018.1 - 0.00096 19.3 7.2 2.9 8.1 0.1 5.5 6 0 0 6 6 5 2 Immunoglobulin domain DUF2075 PF09848.9 PIK47018.1 - 0.0095 15.2 0.0 0.041 13.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 PIK47018.1 - 0.022 14.4 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 PIK47018.1 - 0.033 14.1 0.1 0.089 12.7 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family DnaB_C PF03796.15 PIK47018.1 - 0.039 13.3 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 PIK47018.1 - 0.048 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 PIK47018.1 - 0.091 12.1 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 PIK47018.1 - 0.11 12.7 0.0 21 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain PCO_ADO PF07847.12 PIK47018.1 - 0.13 11.7 0.1 0.26 10.7 0.1 1.4 1 0 0 1 1 1 0 PCO_ADO Ig_3 PF13927.6 PIK47018.1 - 0.17 12.5 10.4 5.4 7.7 0.1 5.1 5 1 1 6 6 5 0 Immunoglobulin domain ACDC PF14733.6 PIK47018.1 - 0.27 11.6 2.4 0.65 10.4 0.4 2.5 2 0 0 2 2 2 0 AP2-coincident C-terminal zf-CCHC PF00098.23 PIK47019.1 - 0.0019 18.2 3.3 0.0019 18.2 3.3 3.1 2 0 0 2 2 2 1 Zinc knuckle NACHT PF05729.12 PIK47020.1 - 2.5e-10 40.5 0.0 1.8e-09 37.8 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK47020.1 - 4e-05 23.3 0.1 0.0092 15.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 PIK47020.1 - 0.026 14.9 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK47020.1 - 0.077 13.4 0.3 0.97 9.9 0.0 3.1 2 1 1 3 3 3 0 RNA helicase DED PF01335.21 PIK47022.1 - 3.3e-06 27.3 0.2 0.041 14.2 0.0 2.3 2 0 0 2 2 2 2 Death effector domain BORA_N PF15280.6 PIK47022.1 - 0.024 14.3 0.0 0.076 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein aurora borealis N-terminus WRNPLPNID PF15017.6 PIK47023.1 - 0.44 11.5 4.1 0.58 11.1 2.4 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box RecR PF02132.15 PIK47023.1 - 9.6 5.9 10.0 0.46 10.1 4.4 1.7 2 0 0 2 2 2 0 RecR protein ZU5 PF00791.20 PIK47024.1 - 1.4e-06 28.5 0.0 3.5e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain DUF3899 PF13038.6 PIK47024.1 - 0.029 14.9 0.4 0.16 12.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Death PF00531.22 PIK47025.1 - 9e-13 48.2 0.2 1.6e-12 47.4 0.2 1.4 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK47025.1 - 1.4e-12 47.7 0.1 2.7e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 ZU5 domain Mononeg_mRNAcap PF14318.6 PIK47025.1 - 0.072 12.3 0.3 0.15 11.3 0.3 1.5 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V NACHT PF05729.12 PIK47026.1 - 1.2e-16 61.1 0.0 2.4e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK47026.1 - 0.00016 21.9 3.1 0.23 11.8 0.2 3.1 2 0 0 2 2 2 2 Death effector domain AAA_25 PF13481.6 PIK47026.1 - 0.00023 20.8 0.0 0.00059 19.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 PIK47026.1 - 0.011 16.2 0.1 0.039 14.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DAP3 PF10236.9 PIK47026.1 - 0.064 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.21 PIK47026.1 - 0.11 11.8 0.0 0.39 10.1 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 PIK47026.1 - 0.14 11.4 0.0 0.5 9.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.14 PIK47026.1 - 0.15 12.1 0.0 0.43 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RVT_1 PF00078.27 PIK47028.1 - 6e-16 58.6 0.0 9.4e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DED PF01335.21 PIK47029.1 - 0.00042 20.6 0.5 0.072 13.4 0.2 2.4 2 0 0 2 2 2 2 Death effector domain DUF5334 PF17268.2 PIK47029.1 - 0.47 10.8 2.1 20 5.6 0.0 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5334) Sacchrp_dh_NADP PF03435.18 PIK47030.1 - 3.6e-21 75.8 0.1 2.3e-20 73.2 0.0 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 PIK47030.1 - 0.0022 17.1 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 PIK47030.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase CE2_N PF17996.1 PIK47030.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal RRM_5 PF13893.6 PIK47031.1 - 1.1e-43 147.8 0.0 2.1e-36 124.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK47031.1 - 5.9e-18 64.5 0.0 9.6e-06 25.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 PIK47031.1 - 1.2e-08 35.0 0.0 3.3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 RRM-like domain RRM_occluded PF16842.5 PIK47031.1 - 1.1e-06 28.4 0.0 0.028 14.3 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RL PF17797.1 PIK47031.1 - 0.0012 18.7 0.0 18 5.3 0.0 3.5 3 0 0 3 3 3 1 RL domain RRM_3 PF08777.11 PIK47031.1 - 0.027 14.5 0.0 0.38 10.8 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif Limkain-b1 PF11608.8 PIK47031.1 - 0.031 14.3 0.0 0.39 10.8 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 SRCR PF00530.18 PIK47032.1 - 2.9e-252 817.1 49.0 4e-28 97.8 0.2 14.0 13 1 0 13 13 13 13 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47032.1 - 5.3e-46 155.1 26.6 6e-05 23.5 0.1 12.5 13 0 0 13 13 13 11 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47032.1 - 4.4e-23 81.9 23.6 0.19 12.3 0.0 12.7 13 0 0 13 13 13 8 Hepsin, SRCR domain YecR PF13992.6 PIK47032.1 - 5.8e-16 58.6 4.3 1.9 8.9 0.1 10.9 11 0 0 11 11 11 6 YecR-like lipoprotein DUF2997 PF11211.8 PIK47032.1 - 1.4 8.8 3.7 4.9 7.0 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2997) Frag1 PF10277.9 PIK47033.1 - 4.1e-39 134.4 15.3 4.7e-39 134.2 15.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family OmpH PF03938.14 PIK47034.1 - 0.0043 17.4 3.5 0.0062 16.9 3.5 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Tup_N PF08581.10 PIK47034.1 - 0.024 14.9 4.3 0.024 14.9 4.3 1.8 2 1 0 2 2 2 0 Tup N-terminal LOH1CR12 PF10158.9 PIK47034.1 - 0.044 13.8 0.5 0.073 13.1 0.5 1.4 1 0 0 1 1 1 0 Tumour suppressor protein Virul_Fac PF10139.9 PIK47034.1 - 0.068 11.4 2.8 0.073 11.3 2.8 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor UPF0242 PF06785.11 PIK47034.1 - 0.37 10.9 8.1 0.45 10.6 8.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 PIK47034.1 - 0.93 10.2 7.9 0.66 10.6 6.2 1.6 1 1 1 2 2 2 0 Initiation control protein YabA TMPIT PF07851.13 PIK47034.1 - 2 7.6 4.8 2.2 7.5 4.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1043 PF06295.12 PIK47034.1 - 5.7 7.0 8.0 9.1 6.3 5.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) TUDOR_5 PF18359.1 PIK47035.1 - 9.6e-22 76.4 0.1 5.2e-21 74.1 0.1 2.4 3 0 0 3 3 3 1 Histone methyltransferase Tudor domain 1 Tudor_4 PF18358.1 PIK47035.1 - 1.2e-21 76.0 0.1 4e-21 74.3 0.1 1.9 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain Pre-SET PF05033.16 PIK47035.1 - 3.7e-17 62.9 9.3 1e-16 61.5 9.3 1.8 1 0 0 1 1 1 1 Pre-SET motif MBD PF01429.19 PIK47035.1 - 2.2e-07 30.5 0.0 5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain SET PF00856.28 PIK47035.1 - 8.2e-06 26.3 0.0 8.2e-06 26.3 0.0 2.8 2 1 0 2 2 2 1 SET domain Agenet PF05641.12 PIK47035.1 - 7.6e-05 23.1 3.2 0.19 12.2 0.1 4.9 4 1 0 4 4 4 1 Agenet domain Arrestin_C PF02752.22 PIK47035.1 - 0.88 10.0 2.8 1 9.8 0.2 2.2 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain SET PF00856.28 PIK47036.1 - 9e-13 49.0 0.0 1.4e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 SET domain zf-RING_2 PF13639.6 PIK47037.1 - 1.4e-13 50.9 6.5 2e-13 50.4 6.5 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 PIK47037.1 - 2.2e-09 36.9 1.5 2.2e-09 36.9 1.5 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK47037.1 - 5.2e-09 35.8 5.6 7.6e-09 35.3 5.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK47037.1 - 3.6e-08 33.6 8.0 9.3e-08 32.2 8.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK47037.1 - 5.7e-07 29.3 6.4 8.3e-07 28.8 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47037.1 - 6.4e-07 29.2 5.2 9.2e-07 28.7 5.2 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK47037.1 - 9.9e-06 25.3 4.1 1.6e-05 24.7 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK47037.1 - 1.1e-05 25.4 0.5 1.1e-05 25.4 0.5 1.8 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK47037.1 - 0.0002 21.1 3.7 0.00038 20.2 3.7 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 PIK47037.1 - 0.0016 18.5 4.9 0.0075 16.3 5.0 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 PIK47037.1 - 0.0044 16.6 5.9 0.0095 15.5 5.9 1.6 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 PIK47037.1 - 0.0066 16.6 5.2 0.02 15.0 5.2 1.7 1 1 0 1 1 1 1 RING-variant domain zinc_ribbon_16 PF17034.5 PIK47037.1 - 0.021 15.0 0.4 0.032 14.5 0.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 PIK47037.1 - 0.1 12.7 3.4 0.27 11.3 3.4 1.7 1 1 0 1 1 1 0 Zinc-finger DUF2310 PF10071.9 PIK47037.1 - 0.17 11.1 1.5 0.15 11.3 0.3 1.5 1 1 1 2 2 2 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Zf_RING PF16744.5 PIK47037.1 - 0.22 11.6 5.1 0.15 12.2 2.7 1.8 1 1 1 2 2 2 0 KIAA1045 RING finger FANCL_C PF11793.8 PIK47037.1 - 0.55 10.5 7.2 3.6 7.8 7.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 PIK47037.1 - 0.69 9.8 4.9 1.2 8.9 4.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 PIK47037.1 - 0.95 9.4 5.6 3.5 7.6 5.6 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 PIK47037.1 - 7.5 6.9 7.8 19 5.7 7.8 1.7 1 1 0 1 1 1 0 RING-like domain Fibrinogen_C PF00147.18 PIK47039.1 - 8.9e-57 192.4 17.2 8.9e-57 192.4 17.2 2.2 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain PAN_1 PF00024.26 PIK47039.1 - 7.4e-07 29.0 8.7 1.3e-06 28.2 0.1 2.7 2 1 0 2 2 2 1 PAN domain NOA36 PF06524.12 PIK47039.1 - 0.00056 19.3 17.8 0.0011 18.4 17.8 1.5 1 0 0 1 1 1 1 NOA36 protein Orf78 PF06024.12 PIK47039.1 - 0.0042 17.4 2.0 0.008 16.5 2.0 1.4 1 0 0 1 1 1 1 Orf78 (ac78) DUF2722 PF10846.8 PIK47039.1 - 0.0069 15.4 4.8 0.0093 14.9 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) FAM176 PF14851.6 PIK47039.1 - 0.19 11.4 5.1 0.18 11.4 3.4 1.9 2 0 0 2 2 2 0 FAM176 family Cwf_Cwc_15 PF04889.12 PIK47039.1 - 0.2 11.4 22.2 0.37 10.5 22.2 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 PIK47039.1 - 0.8 9.7 11.5 1.4 8.9 11.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal GCIP PF13324.6 PIK47039.1 - 1.8 8.1 13.8 3.2 7.3 13.8 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DNA_pol_phi PF04931.13 PIK47039.1 - 4.2 5.3 25.0 5.9 4.9 25.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 PIK47039.1 - 7.5 6.0 13.6 11 5.4 13.6 1.2 1 0 0 1 1 1 0 PPP4R2 Sigma70_ner PF04546.13 PIK47039.1 - 7.7 6.3 12.3 12 5.7 12.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 PIK47039.1 - 8.4 4.5 15.3 11 4.0 15.3 1.0 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.13 PIK47039.1 - 9.2 6.1 18.4 13 5.7 18.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TNFR_c6 PF00020.18 PIK47040.1 - 0.00044 20.6 10.9 0.0024 18.2 11.0 2.4 1 1 1 2 2 2 1 TNFR/NGFR cysteine-rich region Pep1_7 PF17232.2 PIK47040.1 - 0.13 12.7 0.2 0.3 11.6 0.2 1.6 1 0 0 1 1 1 0 Elicitor peptide 1-7 PI3_PI4_kinase PF00454.27 PIK47041.1 - 3.7e-33 115.4 1.5 1.5e-32 113.4 1.5 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 PIK47041.1 - 5.1e-32 110.8 0.8 1.1e-31 109.7 0.8 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 PIK47041.1 - 2.8e-18 66.2 0.2 1e-17 64.4 0.0 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 PX PF00787.24 PIK47041.1 - 5.8e-18 64.9 0.1 2.3e-17 63.0 0.1 2.2 1 0 0 1 1 1 1 PX domain C2 PF00168.30 PIK47041.1 - 4.8e-14 52.5 0.0 2e-13 50.5 0.1 2.0 2 0 0 2 2 2 1 C2 domain PI3K_rbd PF00794.18 PIK47041.1 - 1.5e-08 34.8 0.0 4.4e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 PIK47041.1 - 0.00092 18.6 0.0 0.0025 17.2 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4135) GH3 PF03321.13 PIK47042.1 - 3.4e-54 184.6 0.9 5.9e-54 183.8 0.3 1.5 1 1 0 2 2 2 1 GH3 auxin-responsive promoter Ost5 PF05251.12 PIK47042.1 - 0.6 10.4 9.3 1.3 9.3 9.3 1.6 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Ribosomal_S9 PF00380.19 PIK47043.1 - 4.3e-15 56.3 0.2 1.9e-08 34.8 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S9/S16 OAR PF03826.17 PIK47044.1 - 2.4e-05 24.0 1.4 4.4e-05 23.1 1.4 1.5 1 0 0 1 1 1 1 OAR domain Homeodomain PF00046.29 PIK47045.1 - 4e-15 55.4 0.5 7.5e-15 54.5 0.5 1.4 1 0 0 1 1 1 1 Homeodomain FmiP_Thoc5 PF09766.9 PIK47045.1 - 0.0065 15.8 2.1 0.0078 15.5 2.1 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 CDC45 PF02724.14 PIK47045.1 - 0.43 8.8 11.6 0.47 8.7 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 PIK47045.1 - 0.94 9.1 7.6 1.2 8.8 7.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 PIK47045.1 - 1.2 7.8 5.6 1.2 7.8 5.6 1.1 1 0 0 1 1 1 0 Presenilin Metallophos PF00149.28 PIK47046.1 - 2.1e-19 70.8 0.2 3.9e-19 70.0 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 PIK47046.1 - 3.1e-18 66.1 0.0 7.4e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 PIK47046.1 - 0.0022 18.2 0.0 0.005 17.0 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD_N PF16655.5 PIK47046.1 - 0.0042 17.6 0.1 0.012 16.2 0.0 1.9 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain PhoD PF09423.10 PIK47046.1 - 0.059 12.4 0.2 0.75 8.7 0.1 2.3 2 1 0 2 2 2 0 PhoD-like phosphatase UPF0086 PF01868.16 PIK47047.1 - 7.3e-26 89.9 0.1 1.2e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Molybdop_Fe4S4 PF04879.16 PIK47047.1 - 0.077 13.0 0.3 0.16 12.0 0.3 1.6 1 1 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain Guanylate_cyc PF00211.20 PIK47048.1 - 4.3e-59 199.2 0.1 5.9e-59 198.8 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Guanylate_cyc PF00211.20 PIK47049.1 - 4.7e-20 72.0 0.0 6.8e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.14 PIK47049.1 - 0.043 14.4 0.2 0.71 10.5 0.2 2.4 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1053) Phage_coat PF09063.10 PIK47049.1 - 0.083 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Phage PP7 coat protein zf-AN1 PF01428.16 PIK47051.1 - 1.8e-22 79.2 20.1 4e-11 42.9 10.4 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger MAT1 PF06391.13 PIK47051.1 - 0.011 15.5 1.9 0.021 14.7 1.9 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 IBR PF01485.21 PIK47051.1 - 0.036 14.3 21.8 0.043 14.0 8.3 2.7 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain zf-C5HC2 PF02928.16 PIK47051.1 - 0.25 11.7 12.0 0.32 11.4 3.7 2.5 2 0 0 2 2 2 0 C5HC2 zinc finger zf-C3HC PF07967.13 PIK47051.1 - 4 7.5 10.6 5.5 7.0 1.9 2.4 1 1 1 2 2 2 0 C3HC zinc finger-like Transp_Tc5_C PF04236.15 PIK47051.1 - 5.6 7.4 14.7 3.9 7.9 4.4 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Mito_carr PF00153.27 PIK47052.1 - 1.5e-54 181.9 3.9 1.5e-24 85.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Helicase_C PF00271.31 PIK47053.1 - 3.9e-06 27.2 0.1 0.031 14.6 0.0 2.4 1 1 1 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 PIK47053.1 - 0.00016 21.5 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RVT_2 PF07727.14 PIK47053.1 - 0.0078 15.9 0.0 0.079 12.6 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2066 PF09839.9 PIK47053.1 - 0.21 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2066) SPRY PF00622.28 PIK47054.1 - 1.2e-20 73.8 0.3 2.2e-20 73.0 0.3 1.5 1 0 0 1 1 1 1 SPRY domain DEAD PF00270.29 PIK47054.1 - 2.9e-14 53.2 0.0 4.2e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase NIF PF03031.18 PIK47055.1 - 2.3e-26 92.4 0.0 4.7e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 PIK47055.1 - 6.8e-07 29.6 0.0 2.5e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain FCP1_C PF09309.10 PIK47055.1 - 5.2e-06 26.5 23.0 5.2e-06 26.5 23.0 4.5 2 2 1 4 4 4 2 FCP1, C-terminal PTCB-BRCT PF12738.7 PIK47055.1 - 0.0016 18.4 0.9 0.006 16.5 0.9 2.1 1 1 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 PIK47055.1 - 0.0034 17.2 0.2 1.7 8.5 0.0 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 PIK47055.1 - 0.038 13.8 0.3 14 5.6 0.0 2.7 2 0 0 2 2 2 0 Biotin-requiring enzyme LIG3_BRCT PF16759.5 PIK47055.1 - 0.063 13.6 2.0 0.24 11.7 2.0 2.0 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Ribosomal_S17 PF00366.20 PIK47056.1 - 7.7e-06 25.9 0.6 1.2e-05 25.3 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF3104 PF11302.8 PIK47056.1 - 0.099 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) PIN_6 PF17146.4 PIK47057.1 - 5.2e-31 107.0 2.3 1.5e-30 105.5 0.0 2.6 3 0 0 3 3 3 1 PIN domain of ribonuclease BT1 PF03092.16 PIK47057.1 - 1.6 6.9 3.1 2.3 6.4 3.1 1.2 1 0 0 1 1 1 0 BT1 family Macoilin PF09726.9 PIK47057.1 - 2.1 6.8 11.9 2.7 6.4 11.9 1.1 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 PIK47057.1 - 3.6 7.7 14.6 5.4 7.1 14.6 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated NOB1_Zn_bind PF08772.11 PIK47058.1 - 1.9e-25 88.8 2.6 2.8e-25 88.3 2.6 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.7 PIK47058.1 - 0.013 15.5 0.5 0.027 14.5 0.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 PIK47058.1 - 0.017 14.8 0.3 0.039 13.7 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-TFIIIC PF12660.7 PIK47058.1 - 0.029 14.3 0.5 0.046 13.7 0.5 1.3 1 1 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex DUF2321 PF10083.9 PIK47058.1 - 0.07 12.8 0.3 0.12 12.0 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) HypA PF01155.19 PIK47058.1 - 0.077 13.0 0.3 0.13 12.3 0.3 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RNA_POL_M_15KD PF02150.16 PIK47058.1 - 0.59 10.0 5.8 0.24 11.3 1.7 2.4 3 1 0 3 3 3 0 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 PIK47058.1 - 0.74 9.8 3.9 1.8 8.6 0.9 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain DUF4201 PF13870.6 PIK47059.1 - 1.8e-51 174.4 27.8 1.8e-51 174.4 27.8 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4201) TolA_bind_tri PF16331.5 PIK47059.1 - 0.00081 19.4 2.7 0.00081 19.4 2.7 4.4 3 1 1 4 4 4 1 TolA binding protein trimerisation DUF2937 PF11157.8 PIK47059.1 - 0.15 11.7 3.3 1 9.1 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF948 PF06103.11 PIK47059.1 - 2 8.7 7.8 0.94 9.8 0.2 3.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phage_GP20 PF06810.11 PIK47059.1 - 2.2 8.1 38.4 0.11 12.2 3.2 5.0 1 1 4 5 5 5 0 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.12 PIK47059.1 - 6 7.0 43.1 0.93 9.6 3.8 3.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.25 PIK47060.1 - 1.6e-05 24.4 0.1 1.8e-05 24.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47060.1 - 0.11 11.8 0.1 0.11 11.7 0.1 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 PIK47061.1 - 1.3e-44 152.5 0.1 1.6e-44 152.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47061.1 - 5.3e-08 32.5 0.0 7.2e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK47061.1 - 1.1e-06 28.8 0.1 2.2e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK47061.1 - 0.0043 15.9 0.0 0.012 14.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 PIK47061.1 - 0.017 14.5 0.3 0.027 13.8 0.3 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK47061.1 - 0.025 14.2 0.1 0.048 13.2 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 PIK47061.1 - 0.073 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF667 PF05018.13 PIK47062.1 - 4.5e-66 222.1 1.8 6.2e-66 221.6 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) SGBP_B_XBD PF18329.1 PIK47062.1 - 0.071 13.1 0.0 0.088 12.8 0.0 1.2 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain LSM PF01423.22 PIK47063.1 - 1.1e-16 60.3 0.6 1.4e-16 59.9 0.6 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 PIK47063.1 - 0.05 13.3 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Hfq protein API5 PF05918.11 PIK47063.1 - 0.5 9.1 4.0 0.61 8.8 4.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) 5_nucleotid_C PF02872.18 PIK47064.1 - 3.1e-35 121.7 0.0 4.8e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK47064.1 - 5.5e-06 27.0 0.0 1e-05 26.2 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Cir_N PF10197.9 PIK47065.1 - 4.2e-07 30.0 7.8 4.2e-07 30.0 7.8 4.5 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR EGF_3 PF12947.7 PIK47066.1 - 1.4e-19 69.9 73.9 3e-06 27.3 7.8 6.5 6 1 1 7 7 7 4 EGF domain TILa PF12714.7 PIK47066.1 - 2.2e-16 59.5 41.8 1.4e-06 28.1 3.6 4.9 5 0 0 5 5 5 4 TILa domain EGF_MSP1_1 PF12946.7 PIK47066.1 - 0.028 14.5 4.9 0.028 14.5 4.9 5.5 5 0 0 5 5 5 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK47066.1 - 0.14 12.6 58.9 0.35 11.3 8.1 5.3 4 2 0 4 4 4 0 EGF-like domain Baculo_PEP_C PF04513.12 PIK47067.1 - 0.00024 21.2 0.6 0.00044 20.3 0.6 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus IFT57 PF10498.9 PIK47067.1 - 0.015 14.2 2.6 0.022 13.8 2.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 PIK47067.1 - 0.21 11.6 1.7 0.67 10.0 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) BshC PF10079.9 PIK47067.1 - 0.28 9.9 2.5 0.38 9.4 2.5 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC XhlA PF10779.9 PIK47067.1 - 0.37 11.0 2.8 0.5 10.6 1.5 1.8 1 1 1 2 2 2 0 Haemolysin XhlA TIL PF01826.17 PIK47068.1 - 0.44 10.8 15.3 0.21 11.9 12.4 1.9 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK47069.1 - 9.4e-11 41.9 0.6 1.3e-10 41.5 0.0 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47069.1 - 2.4e-06 27.4 5.2 8e-06 25.7 3.5 2.3 2 0 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK47069.1 - 6e-05 23.1 9.7 0.00032 20.8 8.5 2.3 1 1 1 2 2 2 1 EGF domain Fibrinogen_C PF00147.18 PIK47070.1 - 1.7e-10 41.1 6.0 1.2e-05 25.2 0.1 2.6 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK47070.1 - 4.1e-05 23.7 5.8 4.1e-05 23.7 5.8 2.5 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK47070.1 - 0.001 19.0 4.2 0.001 19.0 4.2 2.3 1 1 1 2 2 2 1 TILa domain DUF1799 PF08809.11 PIK47070.1 - 0.012 15.8 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Phage related hypothetical protein (DUF1799) DUF3043 PF11241.8 PIK47070.1 - 2.5 8.1 5.8 2.9 7.9 4.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Fibrinogen_C PF00147.18 PIK47071.1 - 9.8e-53 179.2 11.4 1.7e-50 171.9 11.4 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47072.1 - 3.2e-36 125.2 0.8 3.7e-36 125.0 0.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK47072.1 - 0.8 10.0 17.1 0.076 13.3 12.4 1.7 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain Pyr_redox_2 PF07992.14 PIK47073.1 - 1.3e-30 106.6 4.6 5.9e-29 101.2 4.6 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK47073.1 - 1.8e-14 54.0 1.5 2.9e-11 43.8 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK47073.1 - 2.2e-06 27.5 4.0 0.27 10.7 0.0 3.1 3 0 0 3 3 3 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK47073.1 - 3.2e-06 26.6 0.0 0.00039 19.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 PIK47073.1 - 1e-05 25.9 0.6 0.15 12.6 0.0 2.6 2 1 0 2 2 2 2 Putative NAD(P)-binding K_oxygenase PF13434.6 PIK47073.1 - 2.3e-05 23.7 0.9 0.0025 17.0 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK47073.1 - 0.00055 20.1 1.3 0.39 11.0 0.0 2.4 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 PIK47073.1 - 0.0011 17.8 3.2 0.34 9.6 0.2 3.0 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.21 PIK47073.1 - 0.0011 18.3 0.6 0.53 9.5 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 PIK47073.1 - 0.0015 18.8 1.6 0.27 11.5 0.1 2.7 2 0 0 2 2 2 1 TrkA-N domain Lycopene_cycl PF05834.12 PIK47073.1 - 0.0072 15.4 3.8 0.036 13.1 0.1 2.5 2 1 1 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 PIK47073.1 - 0.011 15.8 1.1 2.1 8.3 0.0 2.9 2 1 1 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 PIK47073.1 - 0.012 14.5 4.9 1.5 7.6 0.3 3.1 3 0 0 3 3 3 0 Tryptophan halogenase Semialdhyde_dh PF01118.24 PIK47073.1 - 0.038 14.4 2.5 4.7 7.7 0.2 3.1 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Amino_oxidase PF01593.24 PIK47073.1 - 0.041 13.2 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase IlvN PF07991.12 PIK47073.1 - 0.088 12.4 2.9 1.4 8.5 0.0 3.1 3 1 1 4 4 4 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 PIK47073.1 - 0.17 11.2 0.5 10 5.4 0.0 2.3 2 0 0 2 2 2 0 ThiF family UDPG_MGDP_dh_N PF03721.14 PIK47073.1 - 0.27 10.8 2.2 2.8 7.5 0.1 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 PIK47073.1 - 0.39 9.9 1.8 2.1 7.5 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 PIK47073.1 - 2.9 6.9 10.2 8.1 5.4 0.0 3.2 2 1 1 3 3 3 0 Glucose inhibited division protein A Fibrinogen_C PF00147.18 PIK47074.1 - 2.5e-39 135.4 3.4 3.6e-39 134.8 3.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK47074.1 - 4.2e-05 23.0 0.8 5.7e-05 22.5 0.3 1.4 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain EGF_3 PF12947.7 PIK47074.1 - 0.00011 22.3 9.9 0.00011 22.3 9.9 2.6 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK47074.1 - 0.00033 20.5 1.9 0.00075 19.4 1.9 1.6 1 0 0 1 1 1 1 TILa domain EGF_Tenascin PF18720.1 PIK47074.1 - 0.012 15.6 8.5 0.1 12.7 0.1 2.6 2 0 0 2 2 2 0 Tenascin EGF domain Pkinase_Tyr PF07714.17 PIK47075.1 - 1.8e-98 328.9 0.0 2.3e-98 328.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47075.1 - 1.6e-47 162.1 0.0 3e-47 161.2 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 PIK47075.1 - 2.5e-26 91.6 0.2 5e-26 90.6 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK47075.1 - 1.2e-14 53.7 0.0 2.6e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK47075.1 - 1.5e-11 44.0 0.1 5e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK47075.1 - 4.8e-09 35.8 0.0 1.5e-08 34.2 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Haspin_kinase PF12330.8 PIK47075.1 - 0.00016 20.7 0.1 0.00042 19.4 0.1 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK47075.1 - 0.0041 16.5 0.0 0.0069 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK47075.1 - 0.017 14.5 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK47075.1 - 0.037 13.9 0.0 0.11 12.4 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family SRCR PF00530.18 PIK47076.1 - 6.3e-178 578.6 68.7 8.9e-28 96.7 3.5 9.3 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47076.1 - 2.7e-34 117.6 42.8 5.3e-05 23.7 7.6 9.2 8 0 0 8 8 8 8 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47076.1 - 5e-12 46.3 18.0 1 9.9 0.3 8.0 7 1 1 8 8 8 5 Hepsin, SRCR domain Sushi PF00084.20 PIK47076.1 - 1.2e-10 41.8 5.6 1.4e-10 41.6 2.6 3.0 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Arena_nucleocap PF00843.17 PIK47076.1 - 0.18 10.7 1.9 25 3.7 0.1 3.5 4 0 0 4 4 4 0 Arenavirus nucleocapsid N-terminal domain PNMA PF14893.6 PIK47077.1 - 4.5e-12 46.0 0.7 7.4e-12 45.3 0.7 1.3 1 0 0 1 1 1 1 PNMA Blo-t-5 PF11642.8 PIK47077.1 - 0.0022 17.9 0.5 0.018 15.0 0.1 2.2 2 0 0 2 2 2 1 Mite allergen Blo t 5 NACHT PF05729.12 PIK47078.1 - 8.5e-10 38.8 0.0 1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK47078.1 - 0.014 15.0 0.0 0.029 13.9 0.0 1.5 2 0 0 2 2 2 0 AAA domain VWA_3 PF13768.6 PIK47079.1 - 1.1e-18 67.6 0.0 1.9e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain ITI_HC_C PF06668.12 PIK47079.1 - 4.5e-18 65.6 0.0 8.5e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA PF00092.28 PIK47079.1 - 1.8e-13 51.1 0.1 2.8e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK47079.1 - 8.6e-10 39.2 0.0 2.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Kelch_6 PF13964.6 PIK47080.1 - 0.13 12.6 0.1 0.39 11.1 0.1 1.8 2 0 0 2 2 2 0 Kelch motif NACHT PF05729.12 PIK47081.1 - 7.9e-12 45.4 0.0 2.2e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK47081.1 - 0.0012 18.5 0.0 0.004 16.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 PIK47081.1 - 0.072 13.1 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DAP3 PF10236.9 PIK47081.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mito_fiss_reg PF05308.11 PIK47081.1 - 2.7 8.0 6.9 5 7.1 6.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 PIK47081.1 - 5.6 7.0 10.6 11 6.1 10.6 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NACHT PF05729.12 PIK47082.1 - 0.013 15.4 0.0 0.048 13.6 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Peptidase_M73 PF12389.8 PIK47082.1 - 0.016 15.1 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Camelysin metallo-endopeptidase C2 PF00168.30 PIK47083.1 - 2.5e-20 72.7 0.0 5.5e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ketoacyl-synt_C PF02801.22 PIK47089.1 - 9.9e-08 32.0 0.0 2.2e-07 30.9 0.1 1.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 PIK47089.1 - 0.053 14.0 0.1 0.07 13.6 0.1 1.2 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension ketoacyl-synt PF00109.26 PIK47090.1 - 2.5e-27 96.0 0.0 8.6e-27 94.3 0.0 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 PIK47090.1 - 4.6e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 PIK47090.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain IreB PF06135.12 PIK47090.1 - 0.21 11.8 0.0 0.77 10.0 0.0 1.9 2 0 0 2 2 2 0 IreB regulatory phosphoprotein Pkinase PF00069.25 PIK47091.1 - 7.7e-40 136.9 0.0 8.9e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47091.1 - 5.9e-29 101.1 0.0 7.2e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PT PF04886.12 PIK47091.1 - 1.5e-06 27.6 1.7 0.0081 15.7 1.7 2.8 1 1 0 1 1 1 1 PT repeat Kinase-like PF14531.6 PIK47091.1 - 7.2e-05 22.2 0.0 9.7e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Clathrin_bdg PF15045.6 PIK47092.1 - 0.035 14.1 0.1 0.067 13.2 0.1 1.5 1 1 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking Kelch_6 PF13964.6 PIK47092.1 - 0.14 12.5 0.2 0.6 10.5 0.1 2.0 1 1 1 2 2 2 0 Kelch motif NACHT PF05729.12 PIK47093.1 - 4.4e-09 36.5 0.0 6e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK47093.1 - 0.097 12.9 0.0 0.23 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain ig PF00047.25 PIK47094.1 - 0.00071 19.7 0.3 0.11 12.7 0.1 2.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK47094.1 - 0.0016 19.0 0.0 1 10.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK47094.1 - 0.0089 16.3 0.1 2 8.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK47094.1 - 0.0095 16.0 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Pkinase_Tyr PF07714.17 PIK47095.1 - 1.3e-44 152.5 0.0 1.6e-44 152.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47095.1 - 7.2e-11 41.9 0.0 1.2e-10 41.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Nicastrin PF05450.15 PIK47096.1 - 1.5e-43 149.0 0.0 2.8e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 PIK47096.1 - 4.2e-25 88.7 0.0 7.6e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Nicastrin small lobe HSP70 PF00012.20 PIK47097.1 - 2.6e-118 395.8 1.0 3.1e-118 395.6 1.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK47097.1 - 1.1e-14 54.1 0.8 1e-13 50.9 0.2 2.4 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 PIK47097.1 - 4.4e-05 23.9 0.2 0.43 11.0 0.0 2.6 2 1 0 2 2 2 2 Cell division protein FtsA StbA PF06406.11 PIK47097.1 - 9.2e-05 21.8 0.0 0.00019 20.8 0.0 1.5 1 1 0 1 1 1 1 StbA protein BRCT PF00533.26 PIK47097.1 - 0.046 14.1 0.0 0.15 12.5 0.0 1.9 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Histidinol_dh PF00815.20 PIK47097.1 - 0.076 12.0 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Histidinol dehydrogenase TPP_enzyme_N PF02776.18 PIK47097.1 - 0.089 12.4 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Hydantoinase_A PF01968.18 PIK47097.1 - 0.1 11.9 0.1 0.39 9.9 0.1 2.0 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DUF1143 PF06608.11 PIK47098.1 - 1.5e-36 125.7 0.5 1.8e-36 125.4 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1143) Sdh_cyt PF01127.22 PIK47100.1 - 2.6e-10 40.4 0.2 3.1e-10 40.1 0.2 1.0 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit CBFD_NFYB_HMF PF00808.23 PIK47101.1 - 1.9e-21 76.1 1.0 5.7e-21 74.6 0.9 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK47101.1 - 5.3e-16 59.2 0.8 1.2e-15 58.0 0.8 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 PIK47101.1 - 0.11 12.9 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 CENP-S associating Centromere protein X RVT_1 PF00078.27 PIK47102.1 - 1e-16 61.2 0.0 2.1e-16 60.2 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 PIK47103.1 - 0.0013 18.5 0.0 0.0031 17.3 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family 4_1_CTD PF05902.13 PIK47104.1 - 4.8e-26 90.9 15.9 7e-18 64.7 1.9 3.9 3 0 0 3 3 3 3 4.1 protein C-terminal domain (CTD) FERM_C PF09380.10 PIK47104.1 - 6.1e-24 84.2 0.0 1.6e-23 82.9 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK47104.1 - 3.2e-20 72.7 0.0 6.3e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 PIK47104.1 - 2.4e-11 43.5 0.3 8.5e-11 41.8 0.1 2.1 2 0 0 2 2 2 1 FERM adjacent (FA) DAO PF01266.24 PIK47105.1 - 3.3e-10 40.1 0.0 3.6e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 PIK47105.1 - 0.011 15.0 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Ldh_1_N PF00056.23 PIK47105.1 - 0.068 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 PIK47105.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 PIK47105.1 - 0.17 12.1 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 PIK47105.1 - 0.18 11.7 0.1 0.24 11.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 PIK47105.1 - 0.23 10.6 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fibrinogen_C PF00147.18 PIK47106.1 - 5.9e-39 134.2 4.6 1.9e-38 132.5 4.6 1.8 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain 7tm_1 PF00001.21 PIK47107.1 - 2.9e-17 62.9 5.4 3.6e-17 62.5 5.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YbgT_YccB PF08173.11 PIK47107.1 - 0.13 12.4 1.8 0.34 11.1 1.8 1.6 1 0 0 1 1 1 0 Membrane bound YbgT-like protein SNF PF00209.18 PIK47108.1 - 2.6e-39 135.3 5.5 2.9e-39 135.1 5.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF3311 PF11755.8 PIK47108.1 - 3.2e-05 23.8 6.1 3.2e-05 23.8 6.1 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3311) DUF2339 PF10101.9 PIK47108.1 - 0.0046 15.6 4.3 0.0057 15.3 4.3 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) SNF PF00209.18 PIK47109.1 - 1.9e-191 637.3 28.9 2e-190 633.9 28.9 1.9 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF3311 PF11755.8 PIK47109.1 - 0.0045 16.9 4.5 0.0045 16.9 4.5 4.0 4 0 0 4 4 4 1 Protein of unknown function (DUF3311) GNVR PF13807.6 PIK47109.1 - 0.14 12.1 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase BNR_2 PF13088.6 PIK47110.1 - 2.7e-25 89.2 0.0 8e-25 87.7 0.0 1.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK47110.1 - 1.9e-05 24.0 11.7 0.32 11.2 0.1 4.7 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_3 PF13859.6 PIK47110.1 - 0.0001 21.7 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Suppressor_APC PF11414.8 PIK47111.1 - 8.7e-18 64.2 8.7 2.2e-17 62.9 6.0 2.5 2 0 0 2 2 2 1 Adenomatous polyposis coli tumour suppressor protein Cep57_CLD_2 PF14197.6 PIK47111.1 - 0.086 12.9 0.5 0.086 12.9 0.5 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Csm1_N PF18504.1 PIK47111.1 - 0.91 9.9 4.8 0.39 11.1 0.5 2.5 2 1 1 3 3 3 0 Csm1 N-terminal domain V_ATPase_I PF01496.19 PIK47111.1 - 5.4 4.8 7.9 0.29 9.0 2.4 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 PIK47111.1 - 9.8 6.2 12.8 1.9 8.6 2.2 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Miga PF10265.9 PIK47112.1 - 1.8e-102 344.1 7.1 2.8e-102 343.5 4.0 2.3 1 1 1 2 2 2 1 Mitoguardin Glyoxalase PF00903.25 PIK47112.1 - 0.047 13.9 0.0 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily rve PF00665.26 PIK47113.1 - 1.4e-06 28.5 0.0 3.1e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Integrase core domain HECT PF00632.25 PIK47114.1 - 0.00068 19.2 0.0 0.0014 18.1 0.0 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) COBRA1 PF06209.13 PIK47115.1 - 9.5e-136 453.4 1.3 1.4e-135 452.9 1.3 1.2 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) FbpA PF05833.11 PIK47115.1 - 0.023 13.4 0.4 0.038 12.8 0.4 1.3 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Fibrinogen_C PF00147.18 PIK47116.1 - 3.3e-33 115.3 2.3 3.7e-33 115.2 2.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47117.1 - 3.6e-48 164.3 6.1 6.4e-46 156.9 3.8 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK47117.1 - 6.4e-06 26.3 9.1 6.4e-06 26.3 9.1 3.4 2 1 1 3 3 3 1 EGF domain TILa PF12714.7 PIK47117.1 - 0.00035 20.5 2.7 0.00035 20.5 2.7 3.0 2 1 0 2 2 2 1 TILa domain EGF_2 PF07974.13 PIK47117.1 - 2.8 8.4 15.4 1.7 9.1 8.5 3.1 2 2 0 2 2 2 0 EGF-like domain EB PF01683.18 PIK47117.1 - 7.4 6.9 26.5 7.5 6.9 11.6 3.0 2 1 0 2 2 2 0 EB module Fibrinogen_C PF00147.18 PIK47118.1 - 1.1e-34 120.2 0.9 2e-34 119.4 0.9 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47118.1 - 0.0011 18.9 1.2 0.0011 18.9 1.2 3.3 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK47118.1 - 0.0022 18.2 12.6 0.0022 18.2 12.6 2.5 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain CBX7_C PF17218.3 PIK47120.1 - 0.3 10.8 1.0 0.52 10.1 0.3 1.7 2 0 0 2 2 2 0 CBX family C-terminal motif FAM91_N PF14647.6 PIK47121.1 - 1.4e-140 468.0 2.3 1.8e-140 467.6 2.3 1.2 1 0 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.6 PIK47121.1 - 2e-139 465.1 0.7 1.1e-126 423.2 0.0 2.2 1 1 1 2 2 2 2 FAM91 C-terminus Fibrinogen_C PF00147.18 PIK47122.1 - 1e-41 143.2 0.3 1.3e-41 142.8 0.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK47122.1 - 9.6e-05 22.5 11.6 0.00014 22.0 9.9 2.1 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK47122.1 - 0.00031 20.6 2.1 0.00074 19.4 2.1 1.6 1 0 0 1 1 1 1 TILa domain GldH_lipo PF14109.6 PIK47122.1 - 0.075 13.8 0.5 0.14 13.0 0.5 1.4 1 0 0 1 1 1 0 GldH lipoprotein EGF_CA PF07645.15 PIK47122.1 - 0.41 10.9 10.0 0.26 11.5 3.1 2.6 2 0 0 2 2 2 0 Calcium-binding EGF domain EGF_2 PF07974.13 PIK47122.1 - 1.3 9.5 8.5 5.7 7.4 8.5 2.2 1 1 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK47123.1 - 8.3e-35 120.6 0.2 2.3e-33 115.9 0.2 2.2 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47123.1 - 8.2e-06 25.7 3.4 8.2e-06 25.7 3.4 3.7 3 1 1 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK47123.1 - 9.3e-05 22.5 3.7 9.3e-05 22.5 3.7 4.4 2 2 2 4 4 4 1 EGF domain RVT_1 PF00078.27 PIK47124.1 - 2.2e-05 24.1 0.0 3.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK47125.1 - 5.6e-15 55.5 0.2 7.1e-15 55.1 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1836 PF08876.11 PIK47125.1 - 0.021 14.8 0.6 0.12 12.5 0.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1836) DUF1071 PF06378.11 PIK47125.1 - 0.087 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Fibrinogen_C PF00147.18 PIK47126.1 - 1.2e-35 123.3 2.3 1.8e-35 122.7 2.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK47126.1 - 5.7e-06 26.4 4.2 1.6e-05 25.0 4.2 1.8 1 0 0 1 1 1 1 EGF domain Fibrinogen_C PF00147.18 PIK47127.1 - 7e-08 32.5 15.7 0.00095 19.0 10.7 2.5 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47128.1 - 8.4e-43 146.7 5.2 1.2e-34 120.0 0.8 2.5 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47128.1 - 4.3e-09 36.2 18.2 8.1e-06 25.7 6.1 4.2 3 1 1 4 4 4 2 TILa domain EGF_3 PF12947.7 PIK47128.1 - 8.3e-09 35.5 26.0 5.7e-06 26.4 5.0 4.9 4 2 1 5 5 5 2 EGF domain EGF_2 PF07974.13 PIK47128.1 - 0.021 15.2 9.0 0.021 15.2 9.0 4.9 4 2 0 4 4 4 0 EGF-like domain Crystall PF00030.19 PIK47128.1 - 0.084 13.1 0.5 9.3 6.5 0.1 3.4 3 0 0 3 3 3 0 Beta/Gamma crystallin EGF_3 PF12947.7 PIK47129.1 - 7.6e-10 38.8 22.5 6.9e-07 29.4 9.6 5.9 5 2 1 6 6 6 2 EGF domain TILa PF12714.7 PIK47129.1 - 1.3e-07 31.4 16.2 7e-06 25.9 5.5 5.2 3 1 2 5 5 5 3 TILa domain Fibrinogen_C PF00147.18 PIK47129.1 - 1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47130.1 - 3.2e-19 68.6 80.8 2.6e-05 24.1 4.3 6.9 6 1 1 7 7 7 5 TILa domain EGF_3 PF12947.7 PIK47130.1 - 4.3e-11 42.8 46.2 2.9e-05 24.2 4.8 9.3 7 5 4 11 11 11 4 EGF domain Pkinase PF00069.25 PIK47131.1 - 0.0004 19.8 0.0 0.00056 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47131.1 - 0.00068 19.0 0.0 0.00091 18.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2095 PF09868.9 PIK47133.1 - 0.00052 20.0 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2095) DED PF01335.21 PIK47133.1 - 0.081 13.2 0.3 0.17 12.2 0.3 1.5 1 0 0 1 1 1 0 Death effector domain zf-CCHC PF00098.23 PIK47134.1 - 0.00029 20.7 4.9 0.00045 20.2 4.9 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK47134.1 - 0.0043 16.7 0.8 0.01 15.5 0.8 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK47134.1 - 0.0064 16.4 0.2 0.011 15.7 0.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK47134.1 - 0.0071 16.1 3.3 0.011 15.5 3.3 1.3 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 PIK47134.1 - 0.043 14.2 2.6 0.078 13.4 2.6 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Carla_C4 PF01623.17 PIK47134.1 - 0.064 13.2 0.1 0.19 11.7 0.1 1.7 2 0 0 2 2 2 0 Carlavirus putative nucleic acid binding protein RVT_1 PF00078.27 PIK47135.1 - 2e-12 47.1 0.0 3.3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Per1 PF04080.13 PIK47136.1 - 1.1e-87 294.0 8.8 1.4e-87 293.7 8.8 1.1 1 0 0 1 1 1 1 Per1-like family TPH PF13868.6 PIK47137.1 - 3.1e-14 52.2 118.7 3.1e-14 52.2 118.7 2.0 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain CoA_transf_3 PF02515.17 PIK47138.1 - 2.4e-123 411.9 0.0 2.8e-123 411.7 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III GRIP PF01465.20 PIK47138.1 - 0.028 14.3 0.0 0.48 10.4 0.0 2.3 2 0 0 2 2 2 0 GRIP domain RVT_1 PF00078.27 PIK47139.1 - 1.5e-30 106.4 0.1 1.6e-30 106.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) adh_short PF00106.25 PIK47140.1 - 4.3e-30 104.6 0.0 1.8e-21 76.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK47140.1 - 6.8e-26 91.2 0.0 2.4e-19 69.8 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK47140.1 - 1.1e-05 25.5 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK47140.1 - 0.052 13.0 0.0 0.087 12.3 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK47140.1 - 0.12 12.7 0.1 1.1 9.5 0.0 2.1 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Integrin_alpha2 PF08441.12 PIK47141.1 - 5.4e-42 144.3 0.0 3.1e-35 122.0 0.0 2.7 1 1 1 2 2 2 2 Integrin alpha FG-GAP PF01839.23 PIK47141.1 - 2.4e-12 46.7 3.7 5.9e-08 32.7 0.0 4.0 3 0 0 3 3 3 2 FG-GAP repeat FG-GAP_2 PF14312.6 PIK47141.1 - 4.1e-09 36.5 8.9 0.0046 17.2 0.1 5.2 5 0 0 5 5 5 3 FG-GAP repeat VCBS PF13517.6 PIK47141.1 - 1.3e-05 25.6 0.6 0.00097 19.7 0.0 3.2 2 1 1 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1682 PF07946.14 PIK47142.1 - 1.7e-06 27.5 16.8 2.2e-06 27.1 16.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Connexin PF00029.19 PIK47142.1 - 0.025 14.4 0.9 0.03 14.1 0.9 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 PIK47142.1 - 0.13 11.0 0.3 0.14 10.9 0.3 1.2 1 0 0 1 1 1 0 Presenilin Borrelia_P83 PF05262.11 PIK47142.1 - 0.36 9.3 5.6 0.39 9.2 5.6 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein zf-RING_UBOX PF13445.6 PIK47143.1 - 5.7e-10 39.0 5.3 2.5e-09 37.0 5.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47143.1 - 7.2e-09 35.4 7.4 7.2e-09 35.4 7.4 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK47143.1 - 1e-07 31.9 7.9 1e-07 31.9 7.9 3.3 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK47143.1 - 6.8e-07 29.5 6.5 6.8e-07 29.5 6.5 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK47143.1 - 7.4e-07 28.9 9.3 7.4e-07 28.9 9.3 2.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK47143.1 - 1.4e-05 24.8 6.9 1.4e-05 24.8 6.9 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK47143.1 - 2.2e-05 24.5 25.7 0.00023 21.2 10.1 4.0 4 0 0 4 4 3 2 B-box zinc finger zf-RING_5 PF14634.6 PIK47143.1 - 0.00023 21.1 7.8 0.00023 21.1 7.8 3.8 3 0 0 3 3 3 1 zinc-RING finger domain Peptidase_S46 PF10459.9 PIK47143.1 - 0.014 14.1 6.0 0.019 13.6 6.0 1.1 1 0 0 1 1 1 0 Peptidase S46 Baculo_PEP_C PF04513.12 PIK47143.1 - 0.22 11.6 10.7 0.54 10.3 1.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spectrin PF00435.21 PIK47143.1 - 0.35 11.4 14.2 0.035 14.6 2.9 2.9 2 1 0 2 2 2 0 Spectrin repeat NHL PF01436.21 PIK47143.1 - 0.46 10.6 1.9 12 6.2 0.0 3.7 3 1 1 4 4 4 0 NHL repeat Med26 PF08711.11 PIK47143.1 - 1.4 9.0 4.1 27 4.9 2.7 3.1 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Exonuc_VII_L PF02601.15 PIK47143.1 - 1.5 8.4 9.2 2.7 7.5 9.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit YtxH PF12732.7 PIK47143.1 - 1.5 9.4 8.9 1.7 9.2 1.7 2.7 2 1 0 2 2 2 0 YtxH-like protein PCRF PF03462.18 PIK47143.1 - 1.8 8.4 12.3 0.066 13.1 3.7 2.3 1 1 2 3 3 3 0 PCRF domain Occludin_ELL PF07303.13 PIK47143.1 - 1.9 9.2 10.8 0.16 12.7 2.3 2.6 2 0 0 2 2 2 0 Occludin homology domain NPV_P10 PF05531.12 PIK47143.1 - 2 8.9 13.1 3.7 8.1 2.1 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 PIK47143.1 - 2.5 9.1 7.0 1.1 10.2 0.2 3.8 4 0 0 4 4 3 0 WD domain, G-beta repeat Noelin-1 PF12308.8 PIK47143.1 - 4.3 7.4 9.8 3.3 7.7 0.8 2.9 2 0 0 2 2 2 0 Neurogenesis glycoprotein FlaC_arch PF05377.11 PIK47143.1 - 8.4 6.9 10.3 6.1 7.3 2.1 3.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) RVT_1 PF00078.27 PIK47144.1 - 7.4e-08 32.2 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK47144.1 - 1.6e-05 25.1 0.0 0.00015 22.0 0.0 2.3 2 0 0 2 2 2 1 GIY-YIG catalytic domain zf-B_box PF00643.24 PIK47145.1 - 1.3e-05 25.3 9.0 4.6e-05 23.5 9.0 2.0 1 0 0 1 1 1 1 B-box zinc finger Baculo_PEP_C PF04513.12 PIK47145.1 - 0.073 13.1 3.1 4.7 7.2 0.1 2.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 PIK47145.1 - 0.14 12.7 8.3 0.78 10.3 3.2 3.1 2 1 0 2 2 2 0 YtxH-like protein Prominin PF05478.11 PIK47145.1 - 0.24 9.3 16.4 0.39 8.6 5.4 2.1 1 1 1 2 2 2 0 Prominin DUF1351 PF07083.11 PIK47145.1 - 0.34 10.6 20.3 0.019 14.8 6.2 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1351) UPF0242 PF06785.11 PIK47145.1 - 0.48 10.5 16.0 2.2 8.4 15.7 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Apolipoprotein PF01442.18 PIK47145.1 - 0.7 9.7 10.1 1.5 8.7 10.1 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Noelin-1 PF12308.8 PIK47145.1 - 1.2 9.2 11.7 0.74 9.8 1.0 3.2 1 1 2 3 3 3 0 Neurogenesis glycoprotein DUF3086 PF11285.8 PIK47145.1 - 1.9 7.5 7.7 0.087 11.9 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) DUF4407 PF14362.6 PIK47145.1 - 2.5 7.4 5.9 3.9 6.7 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) M11L PF11099.8 PIK47145.1 - 3.6 7.8 10.0 0.84 9.9 1.4 3.1 1 1 1 3 3 3 0 Apoptosis regulator M11L like DUF349 PF03993.12 PIK47145.1 - 4.1 7.8 13.1 1.1 9.6 1.9 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) MCM_N PF14551.6 PIK47145.1 - 4.6 7.9 7.0 0.94 10.1 1.9 2.2 1 1 1 2 2 2 0 MCM N-terminal domain TMPIT PF07851.13 PIK47145.1 - 9.5 5.4 17.0 8.9 5.5 5.3 2.3 2 0 0 2 2 2 0 TMPIT-like protein zf-RING_UBOX PF13445.6 PIK47146.1 - 1.4e-10 41.0 5.9 5.7e-10 39.1 5.9 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47146.1 - 2.9e-09 36.6 7.1 2.9e-09 36.6 7.1 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK47146.1 - 1.7e-07 31.3 8.2 1.7e-07 31.3 8.2 3.3 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK47146.1 - 8.9e-07 28.6 8.9 8.9e-07 28.6 8.9 2.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47146.1 - 1.2e-06 28.8 6.3 1.2e-06 28.8 6.3 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK47146.1 - 2.7e-06 27.1 6.1 2.7e-06 27.1 6.1 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK47146.1 - 6.3e-05 23.1 26.5 0.00029 20.9 9.8 4.4 5 0 0 5 5 5 2 B-box zinc finger zf-RING_5 PF14634.6 PIK47146.1 - 0.00015 21.6 6.5 0.00015 21.6 6.5 3.8 3 0 0 3 3 3 1 zinc-RING finger domain Myb_DNA-bind_5 PF13873.6 PIK47146.1 - 0.0031 17.5 2.1 0.05 13.7 0.6 3.2 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain DUF1351 PF07083.11 PIK47146.1 - 0.083 12.7 19.6 0.018 14.8 10.6 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1351) UAE_UbL PF14732.6 PIK47146.1 - 0.26 11.9 3.5 1.4 9.5 2.8 2.8 1 1 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Spectrin PF00435.21 PIK47146.1 - 0.53 10.8 11.1 4.8 7.7 0.9 2.7 1 1 1 2 2 2 0 Spectrin repeat Exonuc_VII_L PF02601.15 PIK47146.1 - 0.81 9.2 9.2 1.4 8.4 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit YtxH PF12732.7 PIK47146.1 - 5.5 7.6 11.3 8.5 7.0 0.9 3.3 2 1 0 2 2 2 0 YtxH-like protein DDE_Tnp_4 PF13359.6 PIK47147.1 - 1e-26 93.5 0.0 1.4e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK47147.1 - 0.0038 16.9 0.2 0.045 13.3 0.2 2.0 1 1 0 1 1 1 1 Plant transposon protein zf-RING_UBOX PF13445.6 PIK47148.1 - 1.5e-11 44.1 5.1 1.5e-11 44.1 5.1 3.3 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47148.1 - 2.7e-10 39.9 8.9 2.7e-10 39.9 8.9 3.7 3 2 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK47148.1 - 2.5e-08 34.0 9.6 2.5e-08 34.0 9.6 3.6 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK47148.1 - 3.6e-08 33.1 6.7 3.6e-08 33.1 6.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK47148.1 - 7.2e-08 32.2 10.5 7.2e-08 32.2 10.5 3.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47148.1 - 1.6e-07 31.5 9.1 1.6e-07 31.5 9.1 3.6 3 1 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK47148.1 - 1.4e-05 24.9 8.6 1.4e-05 24.9 8.6 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK47148.1 - 2.7e-05 24.2 28.3 0.00055 20.0 10.5 4.1 4 1 0 4 4 4 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK47148.1 - 0.00024 20.9 6.7 0.00024 20.9 6.7 4.5 3 2 2 5 5 3 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 PIK47148.1 - 0.0022 17.7 7.7 0.0022 17.7 7.7 4.1 3 2 1 4 4 3 1 RING/Ubox like zinc-binding domain ApbA_C PF08546.11 PIK47148.1 - 0.011 16.0 0.0 0.046 13.9 0.1 2.1 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal zf-RING_UBOX PF13445.6 PIK47149.1 - 1.9e-11 43.8 5.3 1.9e-11 43.8 5.3 3.0 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47149.1 - 1.3e-10 41.0 8.9 1.3e-10 41.0 8.9 3.6 3 2 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK47149.1 - 9.7e-09 35.3 9.4 9.7e-09 35.3 9.4 3.5 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK47149.1 - 5.1e-08 32.7 6.7 5.1e-08 32.7 6.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47149.1 - 7.5e-08 32.6 9.1 7.5e-08 32.6 9.1 3.7 3 1 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK47149.1 - 7.6e-08 32.1 10.7 7.6e-08 32.1 10.7 3.1 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47149.1 - 2.3e-05 24.3 8.8 2.3e-05 24.3 8.8 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK47149.1 - 0.00012 22.2 27.9 0.00048 20.2 10.1 4.1 4 1 0 4 4 3 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK47149.1 - 0.00015 21.5 6.0 0.00015 21.5 6.0 4.4 3 2 1 4 4 2 1 Prokaryotic RING finger family 4 Noelin-1 PF12308.8 PIK47149.1 - 0.00091 19.2 3.0 0.066 13.2 0.2 2.9 2 0 0 2 2 2 1 Neurogenesis glycoprotein Muted PF14942.6 PIK47149.1 - 0.011 16.1 8.4 0.011 16.1 8.4 2.5 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Apolipoprotein PF01442.18 PIK47149.1 - 0.017 15.0 14.8 0.029 14.2 14.8 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF5082 PF16888.5 PIK47149.1 - 0.023 15.0 11.4 0.49 10.7 3.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 PIK47149.1 - 0.12 12.5 5.8 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2935 PF11155.8 PIK47149.1 - 0.15 12.4 6.1 0.11 12.8 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) ApoLp-III PF07464.11 PIK47149.1 - 0.17 12.0 6.7 0.33 11.0 1.2 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Syntaxin-6_N PF09177.11 PIK47149.1 - 0.2 12.3 7.5 2 9.0 1.4 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Piezo_RRas_bdg PF12166.8 PIK47149.1 - 0.83 8.9 4.5 5 6.3 4.5 1.9 1 1 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DUF1664 PF07889.12 PIK47149.1 - 0.9 9.6 6.8 9.5 6.3 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FliD_N PF02465.18 PIK47149.1 - 1.5 9.5 6.4 4.3 8.1 1.1 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus YtxH PF12732.7 PIK47149.1 - 1.6 9.3 6.3 12 6.5 0.8 2.8 2 1 0 2 2 2 0 YtxH-like protein ACCA PF03255.14 PIK47149.1 - 3.1 7.7 11.4 3.6 7.4 2.4 2.6 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TMPIT PF07851.13 PIK47149.1 - 6.9 5.8 11.7 2 7.6 1.5 2.2 2 0 0 2 2 2 0 TMPIT-like protein DUF2408 PF10303.9 PIK47149.1 - 7.3 7.2 14.6 0.81 10.2 4.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF1640 PF07798.11 PIK47149.1 - 7.5 6.6 19.0 0.079 13.0 7.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Prominin PF05478.11 PIK47149.1 - 7.8 4.3 21.4 3.9 5.3 12.6 2.7 2 1 0 2 2 2 0 Prominin DUF1351 PF07083.11 PIK47149.1 - 9.9 5.9 15.7 0.6 9.8 3.4 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1351) zf-RING_UBOX PF13445.6 PIK47150.1 - 2.2e-10 40.4 7.4 8.3e-10 38.5 7.4 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47150.1 - 3e-10 39.8 9.7 3e-10 39.8 9.7 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47150.1 - 3.7e-07 30.4 9.2 3.7e-07 30.4 9.2 3.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK47150.1 - 7.1e-07 29.3 9.0 7.1e-07 29.3 9.0 3.5 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK47150.1 - 2.5e-06 27.2 11.6 2.5e-06 27.2 11.6 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK47150.1 - 4.7e-06 26.3 9.9 4.7e-06 26.3 9.9 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47150.1 - 5.8e-05 23.0 9.9 5.8e-05 23.0 9.9 3.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK47150.1 - 0.0018 18.4 13.1 0.0018 18.4 13.1 3.9 3 1 0 3 3 3 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK47150.1 - 0.0041 17.0 12.1 0.0041 17.0 12.1 3.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 DUF1640 PF07798.11 PIK47150.1 - 3.8 7.5 22.4 0.15 12.1 8.9 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1640) RVT_1 PF00078.27 PIK47151.1 - 3.4e-47 160.8 2.6 5.1e-47 160.2 0.3 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAIM1 PF06905.13 PIK47151.1 - 0.074 12.8 1.5 0.7 9.6 0.0 2.3 2 0 0 2 2 2 0 Fas apoptotic inhibitory molecule (FAIM1) HU-CCDC81_bac_2 PF18175.1 PIK47151.1 - 0.082 12.8 1.6 0.43 10.5 0.2 2.7 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Thiamine_BP PF01910.17 PIK47151.1 - 0.16 11.9 0.1 0.79 9.7 0.0 2.1 2 0 0 2 2 2 0 Thiamine-binding protein zf-C3HC4 PF00097.25 PIK47152.1 - 4.3e-08 32.9 9.6 4.3e-08 32.9 9.6 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK47152.1 - 1.4e-07 31.5 8.7 1.4e-07 31.5 8.7 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK47152.1 - 1.8e-07 31.2 8.0 1.8e-07 31.2 8.0 4.0 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK47152.1 - 0.0085 16.2 13.5 0.0085 16.2 13.5 4.3 3 1 1 4 4 4 2 B-box zinc finger NPV_P10 PF05531.12 PIK47152.1 - 1.7 9.2 5.3 4.8 7.7 0.1 3.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Muted PF14942.6 PIK47152.1 - 3.6 7.9 25.9 1.5 9.2 15.2 2.8 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein Fam20C PF06702.12 PIK47153.1 - 5.5e-41 140.8 0.1 6.1e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 IgGFc_binding PF17517.2 PIK47154.1 - 6.5e-33 114.3 1.7 6.5e-33 114.3 1.7 2.1 1 1 1 2 2 2 1 IgGFc binding protein DUF5001 PF16392.5 PIK47154.1 - 0.024 14.5 0.3 6.1 6.8 0.0 3.8 3 0 0 3 3 3 0 Ig-like domain UCR_UQCRX_QCR9 PF05365.12 PIK47154.1 - 0.1 12.5 0.1 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RVT_1 PF00078.27 PIK47155.1 - 9.6e-22 77.6 0.0 1.6e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK47155.1 - 5.5e-16 58.4 0.0 8.8e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47155.1 - 4.3e-05 23.8 0.0 7.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PAD PF03068.15 PIK47155.1 - 0.0099 14.9 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK47155.1 - 0.048 13.0 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Retrotrans_gag PF03732.17 PIK47156.1 - 0.028 14.7 0.0 3 8.2 0.0 2.5 1 1 1 2 2 2 0 Retrotransposon gag protein RT_RNaseH PF17917.1 PIK47157.1 - 2.9e-37 127.1 0.0 5.4e-37 126.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK47157.1 - 1.8e-36 124.2 0.0 3.3e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47157.1 - 4.4e-23 82.0 0.0 7.6e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK47157.1 - 0.026 13.5 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK47157.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SCAN PF02023.17 PIK47158.1 - 2.6e-11 43.2 0.0 4.9e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK47158.1 - 7.2e-06 25.8 3.0 1.4e-05 24.9 3.0 1.5 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 PIK47158.1 - 0.02 15.5 0.0 0.047 14.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Retrotrans_gag PF03732.17 PIK47158.1 - 0.051 13.9 0.0 1.6 9.0 0.0 2.5 1 1 1 2 2 2 0 Retrotransposon gag protein His_Phos_1 PF00300.22 PIK47158.1 - 0.075 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) RT_RNaseH PF17917.1 PIK47159.1 - 2.9e-37 127.1 0.0 5.4e-37 126.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK47159.1 - 1.8e-36 124.2 0.0 3.3e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47159.1 - 4.4e-23 82.0 0.0 7.6e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK47159.1 - 0.026 13.5 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK47159.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SCAN PF02023.17 PIK47160.1 - 1.4e-11 44.1 0.0 2.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK47160.1 - 5.1e-06 26.3 3.0 9.4e-06 25.5 3.0 1.5 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK47160.1 - 0.024 14.9 0.5 0.94 9.8 0.0 2.7 2 1 1 3 3 3 0 Retrotransposon gag protein His_Phos_1 PF00300.22 PIK47160.1 - 0.041 13.6 0.0 0.098 12.3 0.0 1.6 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) RT_RNaseH_2 PF17919.1 PIK47161.1 - 7.5e-37 125.4 0.0 1.1e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47161.1 - 1.3e-34 118.6 0.0 1.8e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47162.1 - 1e-23 84.0 0.0 1.4e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK47162.1 - 0.0097 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) Retrotrans_gag PF03732.17 PIK47163.1 - 0.029 14.6 0.0 3 8.2 0.0 2.5 1 1 1 2 2 2 0 Retrotransposon gag protein BRCT PF00533.26 PIK47164.1 - 0.0023 18.2 0.0 0.01 16.2 0.0 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 PIK47164.1 - 0.0047 16.8 0.0 0.015 15.1 0.0 1.9 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 PIK47164.1 - 0.087 13.2 0.0 0.27 11.7 0.0 1.8 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain CDC45 PF02724.14 PIK47165.1 - 0.0027 16.1 13.3 0.0026 16.1 13.3 1.1 1 0 0 1 1 1 1 CDC45-like protein Mpp10 PF04006.12 PIK47165.1 - 0.0039 15.7 16.6 0.0047 15.4 16.6 1.0 1 0 0 1 1 1 1 Mpp10 protein SDA1 PF05285.12 PIK47165.1 - 0.033 13.6 21.2 0.037 13.4 21.2 1.1 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 PIK47165.1 - 0.083 12.3 15.7 0.095 12.1 15.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 PIK47165.1 - 0.21 9.8 22.9 0.27 9.4 22.9 1.2 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 PIK47165.1 - 0.47 9.2 9.5 0.51 9.1 9.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein YL1 PF05764.13 PIK47165.1 - 1.1 9.3 21.9 1.6 8.8 21.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.13 PIK47165.1 - 2.3 6.2 32.1 2.9 5.9 32.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 PIK47165.1 - 2.4 7.4 21.0 2.8 7.2 21.0 1.1 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.11 PIK47165.1 - 7.5 5.0 19.2 9.4 4.6 19.2 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Calx-beta PF03160.14 PIK47166.1 - 2.8e-71 236.0 13.2 7.2e-16 58.2 0.1 6.0 5 1 0 5 5 5 5 Calx-beta domain Cadherin_3 PF16184.5 PIK47167.1 - 1.7e-223 726.7 35.9 2.2e-26 92.0 0.4 12.4 11 2 1 12 12 12 12 Cadherin-like Big_9 PF17963.1 PIK47167.1 - 2.8e-10 40.8 44.4 1e-05 26.2 0.8 11.2 10 1 0 11 11 11 3 Bacterial Ig domain Cadherin_4 PF17803.1 PIK47167.1 - 6e-07 30.0 39.0 0.28 11.8 0.0 10.1 10 2 2 12 12 12 5 Bacterial cadherin-like domain Big_5 PF13205.6 PIK47167.1 - 0.19 12.4 2.1 8 7.2 0.2 3.3 2 0 0 2 2 2 0 Bacterial Ig-like domain Asp_protease_2 PF13650.6 PIK47168.1 - 0.0012 19.4 0.0 0.0021 18.7 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease C2 PF00168.30 PIK47169.1 - 2.8e-07 30.8 0.0 5.1e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK47170.1 - 1.2e-07 31.9 0.0 0.12 12.6 0.0 4.2 3 1 0 3 3 3 2 C2 domain DUF1670 PF07900.11 PIK47170.1 - 0.12 11.7 0.2 0.21 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) zf-H2C2_2 PF13465.6 PIK47172.1 - 3.2e-62 204.3 69.9 1.8e-08 34.4 0.3 11.1 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.26 PIK47172.1 - 1.3e-45 151.4 83.1 6e-06 26.4 1.4 11.3 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK47172.1 - 2.3e-31 105.7 81.4 0.0011 19.6 3.1 11.2 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK47172.1 - 1.2e-10 41.4 64.9 0.00082 19.6 0.5 10.9 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK47172.1 - 9.3e-08 31.9 76.5 0.0015 18.5 3.1 10.3 10 0 0 10 10 10 7 C2H2-type zinc finger Elf1 PF05129.13 PIK47172.1 - 0.00016 21.6 45.7 0.12 12.4 2.0 6.7 1 1 6 7 7 7 4 Transcription elongation factor Elf1 like zf-H2C2_5 PF13909.6 PIK47172.1 - 0.00044 19.9 0.7 0.00044 19.9 0.7 10.3 12 2 0 12 12 11 2 C2H2-type zinc-finger domain PyrI_C PF02748.15 PIK47172.1 - 0.0005 19.9 32.4 11 6.0 0.1 10.2 10 1 1 11 11 11 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 PIK47172.1 - 0.001 19.8 35.1 0.22 12.3 1.9 6.2 1 1 4 5 5 5 2 zinc-ribbon family DUF3268 PF11672.8 PIK47172.1 - 0.012 16.0 28.2 0.091 13.1 0.2 5.6 2 2 4 7 7 7 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.10 PIK47172.1 - 0.037 14.2 0.4 0.037 14.2 0.4 8.2 6 2 1 8 8 8 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 PIK47172.1 - 0.11 12.5 53.6 0.19 11.7 0.2 11.1 11 0 0 11 11 11 0 zinc-finger of a C2HC-type Zf_RING PF16744.5 PIK47172.1 - 0.15 12.2 40.3 8.1 6.6 0.1 9.3 1 1 10 11 11 11 0 KIAA1045 RING finger zf-met PF12874.7 PIK47172.1 - 0.18 12.3 62.9 0.39 11.2 0.6 9.9 11 0 0 11 11 11 0 Zinc-finger of C2H2 type zf_PR_Knuckle PF18445.1 PIK47172.1 - 0.74 9.7 4.9 34 4.4 0.0 4.7 5 0 0 5 5 5 0 PR zinc knuckle motif zinc_ribbon_9 PF14369.6 PIK47172.1 - 0.86 9.9 23.4 6.6 7.1 1.3 7.5 6 1 2 8 8 8 0 zinc-ribbon BolA PF01722.18 PIK47172.1 - 1 9.6 17.1 7.1 7.0 1.2 5.4 3 2 1 4 4 4 0 BolA-like protein zinc_ribbon_12 PF11331.8 PIK47172.1 - 1.3 8.8 0.0 1.3 8.8 0.0 6.2 7 0 0 7 7 7 0 Probable zinc-ribbon domain Yippee-Mis18 PF03226.14 PIK47172.1 - 3.6 7.9 32.9 0.51 10.6 7.9 5.7 2 2 4 6 6 6 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PHF5 PF03660.14 PIK47172.1 - 4.7 7.5 24.3 5.2 7.3 0.3 4.9 1 1 3 5 5 5 0 PHF5-like protein DUF1360 PF07098.11 PIK47172.1 - 8.3 6.4 10.0 1.2 9.1 0.3 4.0 3 2 2 5 5 5 0 Protein of unknown function (DUF1360) NPL PF17800.1 PIK47173.1 - 1.8e-16 60.6 0.2 3.3e-16 59.8 0.2 1.3 1 0 0 1 1 1 1 Nucleoplasmin-like domain Acyl-CoA_dh_M PF02770.19 PIK47174.1 - 0.062 13.5 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Hemerythrin PF01814.23 PIK47175.1 - 0.42 11.2 9.6 0.22 12.1 6.1 2.0 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain FUSC PF04632.12 PIK47175.1 - 2 6.8 10.4 2.3 6.6 10.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3584 PF12128.8 PIK47175.1 - 7.4 3.9 37.3 9.7 3.5 37.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Kelch_1 PF01344.25 PIK47176.1 - 1.9e-38 129.8 7.0 9.4e-08 31.5 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK47176.1 - 2.5e-38 129.1 10.0 9e-07 29.0 0.0 6.2 3 2 3 6 6 6 5 Kelch motif Kelch_5 PF13854.6 PIK47176.1 - 1.3e-33 114.4 8.7 4.5e-08 32.9 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 PIK47176.1 - 1.2e-30 105.3 6.3 2e-06 27.7 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK47176.1 - 1.4e-23 82.6 14.3 7.2e-07 29.4 0.0 7.3 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK47176.1 - 1.5e-23 81.8 10.7 0.0055 16.6 0.0 6.6 6 1 0 6 6 6 6 Kelch motif KDZ PF18758.1 PIK47177.1 - 1.9e-28 99.6 0.9 2.5e-27 96.0 0.3 2.2 2 0 0 2 2 2 1 Kyakuja-Dileera-Zisupton transposase SF-assemblin PF06705.11 PIK47177.1 - 0.096 12.0 0.1 0.61 9.4 0.1 2.2 3 0 0 3 3 3 0 SF-assemblin/beta giardin GTF2I PF02946.14 PIK47178.1 - 2.1e-12 46.9 0.0 4.8e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 GTF2I-like repeat DUF3106 PF11304.8 PIK47178.1 - 0.059 13.8 5.1 0.12 12.9 4.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) PAS_3 PF08447.12 PIK47179.1 - 4e-14 52.7 0.0 1.6e-07 31.5 0.0 2.6 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.6 PIK47179.1 - 2.7e-13 50.0 0.3 8.9e-13 48.4 0.2 1.9 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 PIK47179.1 - 0.00038 20.4 0.1 0.0064 16.5 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 PIK47179.1 - 0.004 17.4 0.0 0.31 11.3 0.0 2.4 2 1 0 2 2 2 1 PAS domain dDENN PF03455.19 PIK47179.1 - 0.063 13.3 0.3 0.79 9.8 0.0 2.6 3 0 0 3 3 3 0 dDENN domain UPF0492 PF15744.5 PIK47180.1 - 3.5e-08 33.1 2.5 4.4e-05 22.9 0.1 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0492 RTC4 PF14474.6 PIK47181.1 - 0.0012 19.0 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain Vps16_C PF04840.12 PIK47182.1 - 6.3e-06 25.5 5.9 0.0064 15.6 0.0 3.2 4 0 0 4 4 4 2 Vps16, C-terminal region RT_RNaseH PF17917.1 PIK47183.1 - 4.6e-36 123.3 0.0 8.1e-36 122.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK47183.1 - 9.6e-36 121.8 0.0 1.6e-35 121.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47183.1 - 5.5e-12 45.7 0.1 8.1e-12 45.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 PIK47183.1 - 0.0017 17.8 0.0 0.0025 17.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain zf-CCHC PF00098.23 PIK47184.1 - 0.025 14.7 1.8 0.025 14.7 1.8 2.9 2 1 0 2 2 2 0 Zinc knuckle RVP PF00077.20 PIK47184.1 - 0.032 14.5 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Retrotrans_gag PF03732.17 PIK47184.1 - 0.081 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein eIF3g PF12353.8 PIK47184.1 - 2.3 8.6 7.3 0.13 12.6 1.7 1.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G DM PF00751.18 PIK47184.1 - 2.7 8.0 13.6 45 4.1 0.0 2.7 2 1 0 2 2 2 0 DM DNA binding domain DUF2318 PF10080.9 PIK47184.1 - 2.9 8.1 5.8 55 4.0 0.0 2.7 2 1 0 2 2 2 0 Predicted membrane protein (DUF2318) zf-CCHC_2 PF13696.6 PIK47184.1 - 8.8 6.3 12.6 0.87 9.5 3.8 2.7 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 PIK47185.1 - 1.3e-136 454.2 0.0 9.3e-68 228.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47185.1 - 4e-64 216.4 0.0 2.1e-33 115.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK47185.1 - 4.2e-13 49.3 0.1 4.9e-07 29.3 0.0 2.5 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 PIK47185.1 - 7.7e-11 41.7 0.9 1.2e-05 24.8 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK47185.1 - 2.2e-08 34.3 0.5 0.0013 18.7 0.0 3.3 2 2 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK47185.1 - 2.6e-08 33.2 2.2 0.003 16.6 0.3 2.3 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_fungal PF17667.1 PIK47185.1 - 4.2e-08 32.4 1.9 4.2e-05 22.5 0.1 2.7 3 0 0 3 3 3 2 Fungal protein kinase Pkinase_C PF00433.24 PIK47185.1 - 3e-07 31.0 0.6 1.9e-06 28.5 0.1 2.6 2 1 0 2 2 2 1 Protein kinase C terminal domain FTA2 PF13095.6 PIK47185.1 - 6.8e-07 29.1 1.0 0.6 9.7 0.0 3.4 3 0 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 PIK47185.1 - 0.00025 20.7 1.7 0.006 16.2 0.1 2.7 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 PIK47185.1 - 0.00073 19.1 0.1 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 PIK47185.1 - 0.052 13.1 0.5 0.4 10.2 0.0 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase SPT_ssu-like PF11779.8 PIK47186.1 - 4.4e-05 23.0 0.8 6.3e-05 22.5 0.8 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like TbpB_C PF17483.2 PIK47187.1 - 0.29 11.5 2.6 1.1 9.7 0.1 2.7 2 1 1 3 3 3 0 C-lobe handle domain of Tf-binding protein B RVT_1 PF00078.27 PIK47188.1 - 1.9e-19 70.1 0.1 2.5e-19 69.7 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_47 PF01532.20 PIK47189.1 - 2.3e-105 353.1 0.0 6.9e-105 351.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 PIK47189.1 - 3.5e-09 36.6 0.0 7.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 PA domain Lung_7-TM_R PF06814.13 PIK47190.1 - 4.3e-33 114.8 6.1 6.3e-32 111.0 5.6 2.2 2 1 0 2 2 2 1 Lung seven transmembrane receptor TatC PF00902.18 PIK47190.1 - 1.6 8.5 6.9 3.6 7.4 6.9 1.6 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) MIF PF01187.18 PIK47191.1 - 3.4e-06 27.3 0.0 4.4e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Peptidase_A17 PF05380.13 PIK47193.1 - 6.1e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK47193.1 - 0.027 14.0 0.0 0.092 12.3 0.0 1.8 1 1 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK47194.1 - 9.1e-31 107.0 0.0 1.2e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase RT_RNaseH_2 PF17919.1 PIK47194.1 - 0.0054 16.7 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47194.1 - 0.014 15.6 0.0 0.028 14.7 0.0 1.6 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DUF5641 PF18701.1 PIK47195.1 - 4.3e-30 103.7 2.5 6.4e-30 103.2 2.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK47195.1 - 3.8e-07 30.3 0.0 6.8e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain GCR1_C PF12550.8 PIK47195.1 - 0.06 13.7 0.9 0.11 12.8 0.9 1.4 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes Calx-beta PF03160.14 PIK47199.1 - 2.1e-22 79.1 0.1 2.9e-12 46.6 0.1 3.3 3 0 0 3 3 3 3 Calx-beta domain PAN_1 PF00024.26 PIK47199.1 - 0.0011 18.9 0.1 0.0019 18.1 0.1 1.3 1 0 0 1 1 1 1 PAN domain PAN_2 PF08276.11 PIK47199.1 - 0.037 14.2 0.3 0.072 13.2 0.3 1.4 1 0 0 1 1 1 0 PAN-like domain PAN_4 PF14295.6 PIK47199.1 - 0.066 13.1 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 PAN domain Couple_hipA PF13657.6 PIK47199.1 - 0.17 12.6 0.0 0.33 11.6 0.0 1.4 1 0 0 1 1 1 0 HipA N-terminal domain EPTP PF03736.17 PIK47200.1 - 7.4e-36 121.9 11.9 1.5e-07 31.2 0.1 7.1 6 1 0 6 6 6 6 EPTP domain Calx-beta PF03160.14 PIK47200.1 - 7.7e-29 99.8 12.8 4.5e-11 42.8 1.1 5.3 5 0 0 5 5 5 3 Calx-beta domain Calx-beta PF03160.14 PIK47201.1 - 0.0052 16.9 0.0 0.011 15.9 0.0 1.5 2 0 0 2 2 2 1 Calx-beta domain Calx-beta PF03160.14 PIK47202.1 - 3.9e-13 49.4 1.8 3.1e-07 30.5 0.1 3.6 4 0 0 4 4 4 2 Calx-beta domain DUF1081 PF06448.11 PIK47202.1 - 0.079 13.4 0.1 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1081) Calx-beta PF03160.14 PIK47203.1 - 1.3e-21 76.7 1.7 3.3e-15 56.1 0.2 3.8 4 0 0 4 4 4 3 Calx-beta domain Calx-beta PF03160.14 PIK47204.1 - 6.3e-21 74.4 10.0 7.3e-09 35.7 0.2 6.1 5 1 1 6 6 6 3 Calx-beta domain DUF4843 PF16132.5 PIK47204.1 - 0.033 13.8 0.0 0.94 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) Exo_endo_phos_2 PF14529.6 PIK47205.1 - 0.018 14.9 0.2 0.17 11.8 0.1 2.5 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase Spore_GerAC PF05504.11 PIK47205.1 - 0.08 13.2 2.1 4.6 7.5 2.1 2.3 1 1 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal 7tm_2 PF00002.24 PIK47206.1 - 1.7e-12 47.1 30.5 2.9e-12 46.4 30.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK47206.1 - 7.2e-08 32.8 2.5 2.2e-07 31.3 2.5 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF4083 PF13314.6 PIK47206.1 - 0.077 12.9 0.0 0.33 10.9 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) fn3 PF00041.21 PIK47207.1 - 2.7e-13 50.1 1.2 5.9e-13 49.0 0.1 2.1 3 0 0 3 3 3 1 Fibronectin type III domain LapA_dom PF06305.11 PIK47207.1 - 0.067 13.0 1.7 0.082 12.7 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 PIK47207.1 - 0.11 13.4 0.0 0.63 11.0 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM132D_C PF15706.5 PIK47207.1 - 0.18 11.6 0.6 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SIT PF15330.6 PIK47207.1 - 0.33 11.4 2.0 0.92 10.0 0.0 2.4 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT CRA PF06589.11 PIK47207.1 - 9.3 6.4 16.2 9.8 6.3 3.1 2.7 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) fn3 PF00041.21 PIK47208.1 - 7.8e-30 103.1 15.4 9.9e-10 38.6 0.4 7.4 7 1 0 7 7 7 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK47208.1 - 1.6e-09 38.2 7.1 0.019 15.5 0.7 5.6 5 2 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK47208.1 - 1.3e-05 25.5 4.1 1.3 9.4 0.0 5.2 5 0 0 5 5 5 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 PIK47208.1 - 0.00021 21.5 0.0 2.4 8.5 0.0 4.6 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III Y_Y_Y PF07495.13 PIK47208.1 - 0.033 14.2 0.1 0.17 11.9 0.0 2.4 2 0 0 2 2 2 0 Y_Y_Y domain Big_5 PF13205.6 PIK47208.1 - 0.15 12.8 4.2 1e+02 3.6 0.0 4.7 5 0 0 5 5 5 0 Bacterial Ig-like domain fn3 PF00041.21 PIK47209.1 - 7.4e-32 109.6 10.5 1.3e-12 47.8 0.1 4.4 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK47209.1 - 1.3e-08 35.3 6.4 0.0023 18.5 0.0 3.6 3 0 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 PIK47209.1 - 0.0061 16.5 0.0 0.13 12.2 0.1 2.7 2 0 0 2 2 2 1 Y_Y_Y domain Glyco_hydro_49 PF03718.13 PIK47209.1 - 0.098 12.7 0.4 21 5.1 0.0 2.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 DUF2369 PF10179.9 PIK47209.1 - 0.12 12.8 0.0 0.62 10.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 PIK47210.1 - 2.5e-20 72.6 2.4 3.2e-08 33.8 0.4 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK47210.1 - 1.3e-05 25.7 3.2 0.063 13.8 1.6 4.1 3 2 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK47210.1 - 3.1e-05 24.0 0.1 0.083 13.0 0.0 2.9 3 0 0 3 3 3 2 Fibronectin type III domain DUF4440 PF14534.6 PIK47211.1 - 1.8e-11 44.4 0.0 2.1e-11 44.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 PIK47211.1 - 4e-07 30.6 0.0 4.7e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 PIK47211.1 - 0.0014 18.7 0.0 0.0018 18.4 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 PIK47211.1 - 0.0094 15.8 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_3 PF13474.6 PIK47211.1 - 0.031 14.5 0.0 0.049 13.9 0.0 1.3 1 1 0 1 1 1 0 SnoaL-like domain NTF2 PF02136.20 PIK47211.1 - 0.059 13.9 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain ASCH PF04266.14 PIK47212.1 - 7.9e-17 61.8 0.0 2.1e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.13 PIK47212.1 - 2.9e-11 43.2 11.6 5.2e-11 42.4 11.6 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-UBP PF02148.19 PIK47212.1 - 2 8.8 8.3 38 4.7 4.5 3.1 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein DUF3668 PF12416.8 PIK47213.1 - 1e-67 228.3 0.0 7e-67 225.5 0.0 2.5 2 0 0 2 2 2 1 Cep120 protein C2 PF00168.30 PIK47213.1 - 0.00024 21.3 0.0 1.8 8.9 0.0 3.7 3 0 0 3 3 3 2 C2 domain DUF4497 PF14924.6 PIK47213.1 - 0.0036 17.7 0.1 0.11 12.9 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF4497) UN_NPL4 PF11543.8 PIK47213.1 - 0.48 10.9 3.3 0.57 10.7 0.9 2.5 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 Arf PF00025.21 PIK47214.1 - 4.8e-19 68.5 0.0 6e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK47214.1 - 3.4e-08 33.7 0.0 3.9e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK47214.1 - 2.2e-07 30.6 0.0 2.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 PIK47214.1 - 1.6e-05 24.5 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK47214.1 - 0.0091 16.1 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 PIK47214.1 - 0.013 14.7 0.1 0.5 9.5 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Gtr1_RagA PF04670.12 PIK47214.1 - 0.039 13.3 0.0 0.047 13.0 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DLIC PF05783.11 PIK47214.1 - 0.042 12.7 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AIF_C PF14721.6 PIK47214.1 - 0.08 13.3 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HAUS2 PF15003.6 PIK47215.1 - 1.2e-32 113.2 3.3 1.3e-32 113.1 3.3 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 Cortex-I_coil PF09304.10 PIK47215.1 - 0.11 12.7 5.4 0.36 11.1 0.1 2.3 2 0 0 2 2 2 0 Cortexillin I, coiled coil ENTH PF01417.20 PIK47215.1 - 0.12 12.5 3.3 2.6 8.1 1.0 2.5 2 1 0 2 2 2 0 ENTH domain NPV_P10 PF05531.12 PIK47215.1 - 0.14 12.6 11.0 5 7.7 0.7 3.8 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 PIK47215.1 - 0.28 11.5 3.7 1.1 9.6 0.1 2.7 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 PIK47215.1 - 0.53 10.3 11.2 0.66 10.0 2.2 3.1 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 H-kinase_dim PF02895.14 PIK47215.1 - 0.56 10.6 0.1 0.56 10.6 0.1 2.8 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain MerR-DNA-bind PF09278.11 PIK47215.1 - 1.2 9.8 8.3 0.36 11.4 0.8 3.5 3 2 0 3 3 3 0 MerR, DNA binding Snapin_Pallidin PF14712.6 PIK47215.1 - 3.4 8.2 13.4 3.4 8.1 2.7 3.6 2 2 1 3 3 3 0 Snapin/Pallidin Syntaxin_2 PF14523.6 PIK47215.1 - 6.3 7.2 16.5 0.56 10.6 0.8 2.9 1 1 2 3 3 3 0 Syntaxin-like protein PseudoU_synth_2 PF00849.22 PIK47216.1 - 4.7e-26 91.8 0.4 7e-26 91.2 0.1 1.4 2 0 0 2 2 2 1 RNA pseudouridylate synthase Lipase_3 PF01764.25 PIK47216.1 - 0.048 13.5 0.0 0.57 10.1 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) AMP-binding_C_2 PF14535.6 PIK47216.1 - 0.13 12.6 0.3 1.3 9.4 0.1 2.2 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain Lectin_C PF00059.21 PIK47217.1 - 0.00057 20.6 0.1 0.0018 19.0 0.1 1.9 1 0 0 1 1 1 1 Lectin C-type domain Stk19 PF10494.9 PIK47218.1 - 1.1e-37 130.1 0.0 1.6e-37 129.6 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 DUF3764 PF12594.8 PIK47219.1 - 0.024 14.7 0.1 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) PH PF00169.29 PIK47219.1 - 0.031 14.8 0.1 0.04 14.4 0.1 1.2 1 0 0 1 1 1 0 PH domain 3-dmu-9_3-mt PF06983.13 PIK47219.1 - 0.047 14.2 0.1 0.075 13.6 0.1 1.3 1 1 0 1 1 1 0 3-demethylubiquinone-9 3-methyltransferase EamA PF00892.20 PIK47220.1 - 1.9e-21 76.6 47.3 2.7e-16 60.0 15.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family RRM_1 PF00076.22 PIK47221.1 - 1.4e-33 114.5 1.9 4.1e-16 58.6 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK47221.1 - 1.5e-05 24.8 0.0 1.5 8.7 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 PIK47221.1 - 3.9e-05 23.7 0.0 0.0098 16.0 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_9 PF18444.1 PIK47221.1 - 0.038 13.9 0.2 0.5 10.3 0.0 2.5 3 0 0 3 3 3 0 RNA recognition motif RabGAP-TBC PF00566.18 PIK47222.1 - 4.8e-49 166.9 0.7 7.4e-49 166.3 0.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 PIK47222.1 - 1.6e-29 102.6 0.3 1.3e-28 99.7 0.2 2.4 3 1 0 3 3 3 1 RUN domain SH3_1 PF00018.28 PIK47222.1 - 1.5e-11 43.7 0.1 3e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK47222.1 - 1.8e-09 37.3 0.0 4.6e-09 36.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK47222.1 - 3.8e-09 36.1 0.0 8.7e-09 34.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain HSBP1 PF06825.12 PIK47222.1 - 0.086 12.7 0.1 0.21 11.5 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Sulfatase PF00884.23 PIK47223.1 - 5.5e-24 85.1 0.1 5.9e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 Sulfatase DUF1501 PF07394.12 PIK47223.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Sulfatase PF00884.23 PIK47224.1 - 1.4e-50 172.4 0.0 2e-49 168.7 0.0 2.5 2 1 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 PIK47224.1 - 2.9e-07 30.7 7.0 1.6e-06 28.3 3.5 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 PIK47224.1 - 6.4e-06 26.0 0.0 0.0074 15.9 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 PIK47224.1 - 0.041 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) HEAT PF02985.22 PIK47225.1 - 2e-09 36.9 0.6 0.026 14.8 0.0 5.7 6 0 0 6 6 6 3 HEAT repeat RasGEF_N_2 PF14663.6 PIK47225.1 - 3.2e-05 24.3 1.9 0.083 13.3 0.0 4.0 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cnd1 PF12717.7 PIK47225.1 - 0.0001 22.4 7.4 0.16 12.0 0.0 4.7 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK47225.1 - 0.00025 21.3 0.0 2.9 8.4 0.0 3.9 3 1 0 3 3 3 2 HEAT repeats Proteasom_PSMB PF10508.9 PIK47225.1 - 0.0022 16.6 1.0 0.27 9.7 0.1 2.8 2 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.8 PIK47225.1 - 0.012 15.7 1.1 3.2 7.9 0.1 3.3 2 0 0 2 2 2 0 V-ATPase subunit H RTP1_C1 PF10363.9 PIK47225.1 - 0.03 14.5 6.1 0.12 12.6 0.1 3.8 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 UNC45-central PF11701.8 PIK47225.1 - 0.27 11.2 3.1 23 4.9 0.0 3.5 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central EF-hand_1 PF00036.32 PIK47226.1 - 3.3e-24 82.6 5.6 2.9e-06 26.4 0.1 5.3 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 PIK47226.1 - 9.9e-21 71.9 9.0 8.4e-06 25.3 0.1 5.2 4 1 1 5 5 5 5 EF-hand domain EF-hand_7 PF13499.6 PIK47226.1 - 2.1e-20 72.9 2.4 1.9e-08 34.6 0.3 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK47226.1 - 7.3e-18 64.2 1.6 2.4e-07 30.5 0.2 3.4 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK47226.1 - 4.6e-14 51.2 3.7 4.8e-05 22.7 0.1 4.5 5 0 0 5 5 5 3 EF hand Scytalone_dh PF02982.14 PIK47226.1 - 0.047 13.5 0.0 0.7 9.7 0.0 2.1 2 0 0 2 2 2 0 Scytalone dehydratase REPA_OB_2 PF16900.5 PIK47227.1 - 1.8e-07 31.0 0.1 6.3e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 Replication protein A OB domain CDC24_OB3 PF17244.2 PIK47228.1 - 2.6e-05 24.0 0.6 3.6e-05 23.6 0.6 1.1 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 VHP PF02209.19 PIK47228.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Villin headpiece domain RMI1_C PF16099.5 PIK47228.1 - 0.066 13.1 0.1 0.13 12.1 0.0 1.5 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold Utp12 PF04003.12 PIK47229.1 - 3.4e-05 24.1 3.3 0.0012 19.1 0.2 3.3 3 0 0 3 3 3 1 Dip2/Utp12 Family DUF4564 PF15169.6 PIK47230.1 - 1.5e-23 83.5 0.0 1.9e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) Peptidase_M50 PF02163.22 PIK47230.1 - 0.1 11.9 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M50 zf-FCS PF06467.14 PIK47231.1 - 0.0038 17.1 6.4 0.14 12.1 0.9 2.4 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif zf-C2H2_jaz PF12171.8 PIK47231.1 - 0.053 13.8 0.3 0.053 13.8 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK47231.1 - 0.13 12.3 4.5 9 6.4 0.0 2.6 1 1 1 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 PIK47231.1 - 0.15 13.0 8.7 1.2 10.1 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger DUF4402 PF14352.6 PIK47232.1 - 0.11 13.2 1.0 0.15 12.8 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4402) PQQ_2 PF13360.6 PIK47233.1 - 0.05 13.2 0.0 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 PQQ-like domain ANAPC4_WD40 PF12894.7 PIK47233.1 - 0.097 13.0 0.0 0.5 10.7 0.0 2.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 PIK47234.1 - 3e-30 104.6 0.1 1.1e-17 64.4 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK47234.1 - 1.6e-20 72.9 2.0 8.5e-09 35.5 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK47234.1 - 1.3e-19 68.2 0.4 2.1e-05 24.5 0.1 4.3 4 0 0 4 4 3 3 Ankyrin repeat Ank PF00023.30 PIK47234.1 - 3e-18 65.4 1.1 6.3e-05 23.2 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 PIK47234.1 - 6.1e-18 64.9 0.1 5.9e-11 42.7 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeats (many copies) BRCT PF00533.26 PIK47234.1 - 1.5e-17 63.7 0.1 2.3e-11 43.9 0.0 3.4 3 1 0 3 3 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_6 PF14835.6 PIK47234.1 - 9.5e-17 60.6 6.5 2.5e-16 59.3 6.5 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.5 PIK47234.1 - 1.8e-15 57.1 0.0 2.8e-08 34.1 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK47234.1 - 1.9e-07 30.9 0.0 7.4e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain zf-RING_10 PF16685.5 PIK47234.1 - 0.00024 21.2 9.4 0.00073 19.6 9.4 1.9 1 0 0 1 1 1 1 zinc RING finger of MSL2 PTCB-BRCT PF12738.7 PIK47234.1 - 0.00061 19.7 0.0 0.0016 18.3 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain zf-C3HC4_2 PF13923.6 PIK47234.1 - 0.0043 16.9 17.1 0.0043 16.9 17.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK47234.1 - 0.0071 16.2 17.5 0.022 14.6 17.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47234.1 - 0.072 13.1 16.5 0.17 11.9 16.5 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK47234.1 - 0.55 10.4 16.1 1.6 8.9 16.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK47234.1 - 0.99 9.8 16.8 3.2 8.2 16.8 2.0 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 PIK47234.1 - 1.3 9.1 14.8 4.1 7.5 14.8 1.9 1 0 0 1 1 1 0 RING-type zinc-finger IHABP4_N PF16174.5 PIK47234.1 - 1.7 9.2 29.7 0.025 15.2 17.6 2.3 1 1 1 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Prok-RING_4 PF14447.6 PIK47234.1 - 2 8.3 14.3 5.5 6.9 14.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 MCRS_N PF13325.6 PIK47235.1 - 5.7e-83 277.8 6.5 9.3e-83 277.1 6.5 1.3 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein FHA PF00498.26 PIK47235.1 - 3.4e-06 27.3 0.0 6.8e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain Myb_DNA-binding PF00249.31 PIK47235.1 - 0.0027 17.9 1.0 1.2 9.4 0.0 3.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain Y_phosphatase PF00102.27 PIK47236.1 - 1e-69 234.7 0.0 1.6e-69 234.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK47236.1 - 1.3e-44 150.5 13.8 5.7e-10 39.4 0.0 7.0 6 1 0 6 6 6 6 Fibronectin type III domain DSPc PF00782.20 PIK47236.1 - 0.00036 20.4 0.1 0.0043 16.9 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK47236.1 - 0.00048 20.2 0.0 0.00086 19.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Orthoreo_P10 PF07204.11 PIK47236.1 - 0.002 18.0 0.1 0.0062 16.5 0.1 1.7 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 Shisa PF13908.6 PIK47236.1 - 0.015 15.6 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DOMON PF03351.17 PIK47236.1 - 0.051 13.8 1.4 0.19 12.0 1.4 2.0 1 0 0 1 1 1 0 DOMON domain Myotub-related PF06602.14 PIK47236.1 - 0.14 11.0 0.1 0.24 10.3 0.1 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain TPR_1 PF00515.28 PIK47242.1 - 4.2e-39 130.8 14.5 8.8e-10 38.0 0.5 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 PIK47242.1 - 3e-34 114.4 14.6 3.7e-07 29.8 0.2 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_8 PF13181.6 PIK47242.1 - 2.2e-27 92.9 11.1 3.6e-05 23.6 0.0 9.2 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 PIK47242.1 - 1.7e-23 82.0 2.1 1.4e-06 27.9 0.0 7.2 3 2 4 7 7 7 4 TPR repeat TPR_17 PF13431.6 PIK47242.1 - 8.8e-22 75.9 10.0 0.016 15.6 0.0 10.1 11 0 0 11 11 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 PIK47242.1 - 5.8e-21 74.6 7.7 0.00069 19.9 0.1 8.0 6 4 1 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK47242.1 - 6.5e-21 74.3 18.8 3.8e-13 49.5 0.3 5.5 5 1 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK47242.1 - 2.5e-20 72.7 2.1 0.00024 21.6 0.0 7.1 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 PIK47242.1 - 5.8e-19 67.2 1.4 0.04 14.7 0.0 8.7 4 1 5 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK47242.1 - 4.1e-14 53.0 0.0 2.3e-07 31.3 0.0 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK47242.1 - 1.1e-10 41.5 0.0 0.01 16.0 0.0 6.0 3 3 3 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK47242.1 - 1.4e-07 31.0 0.4 0.0047 16.2 1.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK47242.1 - 9.1e-07 29.1 12.9 6.4 7.6 0.0 8.6 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK47242.1 - 3.1e-06 26.8 10.6 0.81 9.9 0.2 7.8 9 0 0 9 9 9 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK47242.1 - 7.5e-05 21.9 1.0 0.048 12.7 0.1 2.5 1 1 2 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 PIK47242.1 - 0.018 14.9 10.7 1.5 8.8 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK47242.1 - 0.068 12.5 1.8 0.38 10.1 0.1 2.9 2 1 0 3 3 3 0 MalT-like TPR region DUF3726 PF12525.8 PIK47242.1 - 0.079 13.1 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3726) TPR_21 PF09976.9 PIK47242.1 - 0.085 12.6 0.9 9.3 5.9 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 PIK47242.1 - 0.62 9.7 4.6 5.4 6.7 0.2 3.6 2 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Ubiquitin_5 PF18037.1 PIK47243.1 - 2.2e-16 60.0 0.6 9.4e-16 58.0 0.6 2.1 1 0 0 1 1 1 1 Ubiquitin-like domain UBA PF00627.31 PIK47243.1 - 2.6e-16 59.1 0.3 5.9e-05 22.9 0.0 3.8 3 0 0 3 3 3 3 UBA/TS-N domain ubiquitin PF00240.23 PIK47243.1 - 2.4e-05 24.0 0.2 6.5e-05 22.6 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin family HOIP-UBA PF16678.5 PIK47243.1 - 0.00072 19.6 7.5 0.39 10.7 1.2 4.0 4 0 0 4 4 4 2 HOIP UBA domain pair Rad60-SLD_2 PF13881.6 PIK47243.1 - 0.028 14.5 0.7 0.078 13.1 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like TPR_2 PF07719.17 PIK47243.1 - 0.065 13.4 0.4 4.3 7.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2407 PF10302.9 PIK47243.1 - 0.08 13.5 0.1 0.08 13.5 0.1 3.1 4 0 0 4 4 4 0 DUF2407 ubiquitin-like domain YfdX PF10938.8 PIK47243.1 - 0.41 10.6 4.6 2.8 7.8 0.2 3.7 3 1 0 3 3 3 0 YfdX protein Tetraspanin PF00335.20 PIK47244.1 - 2.7e-34 118.9 6.4 3.4e-34 118.5 6.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2892 PF11127.8 PIK47244.1 - 0.012 15.7 1.3 0.012 15.7 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) DUF202 PF02656.15 PIK47244.1 - 3.6 8.1 6.4 1.5 9.3 4.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Arch_flagellin PF01917.16 PIK47244.1 - 6.2 7.0 6.5 6.5 6.9 5.3 1.6 2 0 0 2 2 2 0 Archaebacterial flagellin Consortin_C PF15281.6 PIK47245.1 - 0.1 12.6 0.2 0.25 11.4 0.2 1.6 1 0 0 1 1 1 0 Consortin C-terminus G2F PF07474.12 PIK47245.1 - 0.4 10.4 3.1 6.9 6.4 0.1 2.2 2 0 0 2 2 2 0 G2F domain SpoIIIAH PF12685.7 PIK47246.1 - 0.037 13.8 7.2 0.046 13.6 7.2 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Lin-8 PF03353.15 PIK47246.1 - 0.078 12.5 11.6 0.097 12.2 11.6 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MPM1 PF17234.2 PIK47246.1 - 0.08 13.2 11.4 0.1 12.8 11.4 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF3537 PF12056.8 PIK47246.1 - 0.14 11.0 3.2 0.16 10.8 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Presenilin PF01080.17 PIK47246.1 - 0.25 10.1 8.7 0.26 10.0 8.7 1.0 1 0 0 1 1 1 0 Presenilin Pes-10 PF07149.11 PIK47246.1 - 0.3 10.1 9.6 0.37 9.8 9.6 1.1 1 0 0 1 1 1 0 Pes-10 PPL5 PF18168.1 PIK47246.1 - 0.36 10.1 6.7 0.47 9.7 6.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 FAM60A PF15396.6 PIK47246.1 - 0.37 10.8 8.1 0.43 10.5 8.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2201_N PF13203.6 PIK47246.1 - 0.52 9.9 5.9 0.59 9.7 5.9 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF755 PF05501.11 PIK47246.1 - 0.63 10.3 15.6 1.1 9.6 15.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF755) DUF913 PF06025.12 PIK47246.1 - 0.65 8.9 5.0 0.71 8.8 5.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Paramyxo_ncap PF00973.19 PIK47246.1 - 0.77 8.6 6.8 0.85 8.5 6.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MMU163 PF17119.5 PIK47246.1 - 0.8 8.8 5.5 0.99 8.5 5.5 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis YABBY PF04690.13 PIK47246.1 - 1 9.9 5.0 1.3 9.6 5.0 1.2 1 0 0 1 1 1 0 YABBY protein Connexin PF00029.19 PIK47246.1 - 1.2 8.9 4.7 1.5 8.5 4.7 1.3 1 0 0 1 1 1 0 Connexin Hid1 PF12722.7 PIK47246.1 - 1.4 6.9 10.2 1.5 6.9 10.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 PIK47246.1 - 1.6 6.9 12.2 1.8 6.8 12.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.11 PIK47246.1 - 1.7 7.4 9.1 2 7.2 9.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NPR3 PF03666.13 PIK47246.1 - 2 7.1 10.0 2 7.1 10.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 PIK47246.1 - 2.1 8.4 4.4 2.1 8.3 4.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Vfa1 PF08432.10 PIK47246.1 - 3.5 7.9 15.9 4.4 7.6 15.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1168 PF06658.12 PIK47246.1 - 5.8 6.7 21.4 7.8 6.3 21.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) ALMT PF11744.8 PIK47246.1 - 6.7 5.4 7.9 7.3 5.3 7.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 PIK47246.1 - 7.6 5.3 5.6 8.1 5.2 5.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Arm PF00514.23 PIK47247.1 - 3.2e-57 188.9 10.8 5.5e-06 26.2 0.0 10.2 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK47247.1 - 2.3e-24 85.6 7.8 2.9e-07 30.8 0.4 7.2 2 2 4 7 7 7 6 HEAT repeats HEAT_EZ PF13513.6 PIK47247.1 - 2.7e-12 46.9 11.1 0.14 12.7 0.1 8.8 9 1 1 10 10 10 4 HEAT-like repeat HEAT PF02985.22 PIK47247.1 - 9.5e-10 37.9 18.7 0.73 10.3 0.0 8.9 10 0 0 10 10 10 3 HEAT repeat Adaptin_N PF01602.20 PIK47247.1 - 2.3e-08 33.1 0.0 7e-08 31.5 0.0 2.0 1 1 0 1 1 1 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 PIK47247.1 - 2.6e-08 34.0 0.6 2.8 8.1 0.0 5.7 1 1 4 6 6 6 3 V-ATPase subunit H Cnd1 PF12717.7 PIK47247.1 - 3.8e-07 30.3 1.0 0.4 10.7 0.1 4.2 1 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 PIK47247.1 - 7.5e-06 25.6 0.1 0.94 8.9 0.0 4.5 3 1 2 5 5 5 1 Armadillo-like UNC45-central PF11701.8 PIK47247.1 - 5e-05 23.3 0.9 1 9.3 0.2 3.8 3 1 1 4 4 4 2 Myosin-binding striated muscle assembly central WAPL PF07814.13 PIK47247.1 - 6.4e-05 21.9 0.0 0.28 9.9 0.1 2.9 2 1 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin RasGEF_N_2 PF14663.6 PIK47247.1 - 0.00041 20.7 1.9 4.9 7.6 0.0 5.0 4 1 0 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.7 PIK47247.1 - 0.0018 18.8 0.0 4.2 8.0 0.0 3.5 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region KAP PF05804.12 PIK47247.1 - 0.0082 14.3 0.0 2.9 5.9 0.0 2.4 1 1 0 2 2 2 2 Kinesin-associated protein (KAP) RICTOR_N PF14664.6 PIK47247.1 - 0.016 14.2 1.0 2.1 7.3 0.1 3.7 3 3 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term RTP1_C1 PF10363.9 PIK47247.1 - 0.023 14.9 0.0 11 6.2 0.1 4.2 2 2 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Spo0A_C PF08769.11 PIK47247.1 - 0.14 12.3 0.0 0.75 9.9 0.0 2.2 3 0 0 3 3 3 0 Sporulation initiation factor Spo0A C terminal UQ_con PF00179.26 PIK47248.1 - 2.4e-47 160.1 0.0 3e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK47248.1 - 0.0056 16.4 0.0 0.0078 15.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 PIK47248.1 - 0.016 15.5 0.1 0.024 14.9 0.1 1.5 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 PIK47248.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 UEV domain Pkinase_Tyr PF07714.17 PIK47249.1 - 9e-66 221.8 0.1 2.6e-65 220.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47249.1 - 2.3e-59 200.9 0.0 4.3e-59 200.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain YkyA PF10368.9 PIK47249.1 - 0.072 12.8 4.4 0.15 11.7 4.4 1.4 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DinB PF05163.12 PIK47249.1 - 0.094 12.6 1.4 0.19 11.7 1.4 1.4 1 0 0 1 1 1 0 DinB family Kinase-like PF14531.6 PIK47249.1 - 0.11 11.8 0.0 0.41 9.9 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Mod_r PF07200.13 PIK47250.1 - 0.13 12.4 3.2 12 6.0 0.4 3.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein EGF_2 PF07974.13 PIK47250.1 - 0.31 11.4 8.6 0.77 10.2 8.6 1.7 1 0 0 1 1 1 0 EGF-like domain Ldl_recept_a PF00057.18 PIK47251.1 - 4.9e-176 570.6 396.0 8.6e-11 41.9 13.9 22.5 22 0 0 22 22 22 20 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 PIK47251.1 - 2.3e-14 53.4 72.3 9.7e-09 35.4 9.2 13.4 14 2 0 14 14 14 7 Coagulation Factor Xa inhibitory site Ldl_recept_b PF00058.17 PIK47251.1 - 1.3e-13 51.1 0.8 0.0049 17.3 0.0 5.4 4 1 0 4 4 4 3 Low-density lipoprotein receptor repeat class B DUF5050 PF16472.5 PIK47251.1 - 7.3e-12 45.1 0.0 0.00046 19.5 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF5050) EGF_CA PF07645.15 PIK47251.1 - 1.3e-10 41.3 40.7 2.7e-07 30.7 4.8 23.9 17 5 9 27 27 27 3 Calcium-binding EGF domain cEGF PF12662.7 PIK47251.1 - 8.8e-09 35.1 13.5 3e-06 27.0 3.7 11.7 11 1 0 11 11 11 4 Complement Clr-like EGF-like EGF PF00008.27 PIK47251.1 - 0.0034 17.6 3.1 0.0034 17.6 3.1 22.8 26 0 0 26 26 26 5 EGF-like domain hEGF PF12661.7 PIK47251.1 - 0.036 14.7 0.6 0.036 14.7 0.6 20.2 23 0 0 23 23 23 0 Human growth factor-like EGF OAD_gamma PF04277.13 PIK47251.1 - 0.18 12.4 0.1 0.31 11.7 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain NHL PF01436.21 PIK47251.1 - 9.9 6.4 9.7 58 4.0 0.0 5.8 6 0 0 6 6 6 0 NHL repeat Ldl_recept_b PF00058.17 PIK47252.1 - 2.3e-10 40.7 2.3 4.8e-07 30.1 0.0 4.2 4 0 0 4 4 4 2 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK47252.1 - 6e-05 23.2 7.9 0.0014 18.8 6.6 2.4 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK47252.1 - 0.13 11.8 0.2 0.93 9.0 0.2 2.3 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 PIK47253.1 - 4.9e-19 68.5 0.2 2.5e-06 27.8 0.0 3.6 3 0 0 3 3 3 3 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK47253.1 - 8.7e-13 48.3 20.7 3.4e-06 27.2 6.7 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK47253.1 - 1.7e-08 34.3 4.3 0.00012 21.9 0.9 3.6 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK47253.1 - 2e-07 31.1 6.7 2e-07 31.1 6.7 3.9 2 1 2 4 4 4 1 Calcium-binding EGF domain Ldl_recept_a PF00057.18 PIK47253.1 - 3.7e-07 30.3 5.9 3.7e-07 30.3 5.9 3.7 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A hEGF PF12661.7 PIK47253.1 - 0.016 15.8 2.2 0.016 15.8 2.2 4.1 4 0 0 4 4 4 0 Human growth factor-like EGF zf-CCHC PF00098.23 PIK47255.1 - 3.7e-10 39.4 17.4 4.1e-05 23.5 2.7 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK47255.1 - 3.6e-05 23.4 18.1 0.057 13.2 1.2 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK47255.1 - 4.6e-05 23.2 13.8 0.12 12.2 1.5 3.5 3 0 0 3 3 3 3 Zinc knuckle CLIP1_ZNF PF16641.5 PIK47255.1 - 0.1 12.5 18.1 0.47 10.4 0.2 3.6 3 0 0 3 3 3 0 CLIP1 zinc knuckle MRNIP PF15749.5 PIK47255.1 - 1.3 9.8 8.7 3.7 8.3 8.8 1.8 1 1 0 1 1 1 0 MRN-interacting protein Ldl_recept_a PF00057.18 PIK47256.1 - 6.5e-21 74.3 63.6 3.6e-09 36.7 9.0 5.2 4 1 1 5 5 5 5 Low-density lipoprotein receptor domain class A EHN PF06441.12 PIK47257.1 - 7.6e-33 113.1 1.0 1e-32 112.7 1.0 1.2 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 PIK47257.1 - 1.1e-06 28.5 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK47257.1 - 0.069 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Nexin_C PF08628.12 PIK47260.1 - 7.3e-15 55.5 0.1 7.3e-15 55.5 0.1 2.5 4 0 0 4 4 4 1 Sorting nexin C terminal PX PF00787.24 PIK47260.1 - 1.3e-11 44.5 1.1 4.3e-11 42.8 0.8 2.1 2 0 0 2 2 2 1 PX domain PXA PF02194.15 PIK47260.1 - 2.4e-08 34.2 1.0 1.2e-07 31.9 1.0 2.3 1 0 0 1 1 1 1 PXA domain D123 PF07065.14 PIK47260.1 - 0.11 11.7 4.7 0.93 8.6 0.1 2.8 2 1 0 2 2 2 0 D123 Lactamase_B_6 PF16661.5 PIK47261.1 - 1.8e-15 56.9 0.0 3.6e-13 49.4 0.0 2.9 3 0 0 3 3 3 2 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 PIK47261.1 - 2.6e-05 24.5 0.0 5.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.5 PIK47261.1 - 0.0056 15.9 0.0 0.017 14.4 0.0 1.8 1 1 0 1 1 1 1 Putative beta-lactamase-like family DNA_RNApol_7kD PF03604.13 PIK47262.1 - 9.7e-16 57.2 9.4 1.2e-15 56.8 9.4 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 PIK47262.1 - 0.0093 16.0 0.5 0.012 15.6 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_13 PF09855.9 PIK47262.1 - 0.018 15.2 0.9 0.025 14.7 0.1 1.5 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) A2L_zn_ribbon PF08792.10 PIK47262.1 - 0.02 14.6 0.4 0.031 14.0 0.4 1.3 1 0 0 1 1 1 0 A2L zinc ribbon domain MCM_OB PF17207.3 PIK47262.1 - 0.022 14.6 0.5 0.024 14.5 0.5 1.1 1 0 0 1 1 1 0 MCM OB domain Zn_ribbon_recom PF13408.6 PIK47262.1 - 0.06 13.9 3.1 0.57 10.7 1.0 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain NinD PF17466.2 PIK47262.1 - 0.08 13.0 3.4 0.11 12.6 3.4 1.4 1 1 0 1 1 1 0 Family of unknown function Rubredoxin_2 PF18073.1 PIK47262.1 - 2.3 8.0 6.1 2.9 7.7 0.4 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain Spectrin PF00435.21 PIK47263.1 - 3.5e-18 66.0 38.9 7.5e-10 39.2 3.1 5.5 4 2 1 5 5 5 3 Spectrin repeat SIKE PF05769.11 PIK47264.1 - 0.0027 17.6 0.2 0.0035 17.3 0.2 1.1 1 0 0 1 1 1 1 SIKE family DUF1664 PF07889.12 PIK47264.1 - 0.031 14.3 2.2 0.57 10.2 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3226 PF11536.8 PIK47264.1 - 0.052 13.2 1.3 2 8.0 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3226) Phage_lambda_P PF06992.11 PIK47264.1 - 0.073 12.8 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 Replication protein P DUF4618 PF15397.6 PIK47264.1 - 0.075 12.4 2.7 0.36 10.2 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) APG6_N PF17675.1 PIK47264.1 - 0.085 13.4 1.8 0.12 12.9 1.8 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region HDV_ag PF01517.18 PIK47264.1 - 2 8.2 7.9 0.37 10.6 1.3 2.0 1 1 1 2 2 2 0 Hepatitis delta virus delta antigen DUF433 PF04255.14 PIK47265.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Spectrin PF00435.21 PIK47266.1 - 1.8e-05 25.2 11.7 0.00012 22.5 2.0 2.3 2 0 0 2 2 2 2 Spectrin repeat LOH1CR12 PF10158.9 PIK47266.1 - 0.016 15.3 1.3 0.026 14.5 1.3 1.5 1 0 0 1 1 1 0 Tumour suppressor protein TraF_2 PF13729.6 PIK47266.1 - 0.35 10.2 7.8 6 6.1 0.5 2.9 2 1 1 3 3 3 0 F plasmid transfer operon, TraF, protein Phage_GP20 PF06810.11 PIK47266.1 - 0.43 10.4 11.8 0.81 9.5 8.0 2.1 1 1 0 2 2 2 0 Phage minor structural protein GP20 Prominin PF05478.11 PIK47266.1 - 0.69 7.8 5.8 0.86 7.5 5.3 1.5 1 1 0 1 1 1 0 Prominin 5_nucleotid PF05761.14 PIK47266.1 - 1.7 7.5 6.6 1.2 8.0 5.0 1.5 1 1 1 2 2 2 0 5' nucleotidase family Fib_alpha PF08702.10 PIK47266.1 - 3.8 7.7 8.5 4.9 7.3 5.3 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FapA PF03961.13 PIK47266.1 - 4.1 5.9 7.8 11 4.5 6.6 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A Atg14 PF10186.9 PIK47266.1 - 4.4 6.3 10.5 5.4 6.0 10.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Wbp11 PF09429.10 PIK47266.1 - 6.9 7.2 12.1 0.37 11.2 0.9 2.7 3 1 0 3 3 3 0 WW domain binding protein 11 FAM76 PF16046.5 PIK47266.1 - 8.1 5.7 7.9 11 5.3 7.9 1.3 1 0 0 1 1 1 0 FAM76 protein Spectrin PF00435.21 PIK47267.1 - 4.3e-60 200.7 79.6 4.6e-12 46.4 2.3 7.1 7 0 0 7 7 7 7 Spectrin repeat PilJ PF13675.6 PIK47267.1 - 0.00013 21.9 31.5 0.088 12.8 0.5 6.7 4 2 0 6 6 6 4 Type IV pili methyl-accepting chemotaxis transducer N-term Tup_N PF08581.10 PIK47267.1 - 0.058 13.7 0.3 0.058 13.7 0.3 7.7 7 2 1 8 8 8 0 Tup N-terminal NAAA-beta PF15508.6 PIK47267.1 - 0.1 12.9 2.0 18 5.7 0.0 4.8 4 0 0 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Baculo_PEP_C PF04513.12 PIK47267.1 - 0.12 12.4 35.0 0.76 9.8 0.6 6.4 3 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pilin_GH PF16734.5 PIK47267.1 - 1.1 9.6 3.9 0.88 9.9 0.1 2.7 3 0 0 3 3 3 0 Type IV pilin-like G and H, putative DASH_Dam1 PF08653.10 PIK47267.1 - 8.5 6.3 12.8 14 5.6 0.2 5.6 4 1 1 5 5 5 0 DASH complex subunit Dam1 Mce4_CUP1 PF11887.8 PIK47267.1 - 10 5.5 7.8 5.8 6.3 0.8 3.2 3 1 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative Spectrin PF00435.21 PIK47268.1 - 6.4e-07 29.8 8.1 5.4e-05 23.6 1.1 3.1 2 1 0 3 3 3 2 Spectrin repeat EZH2_WD-Binding PF11616.8 PIK47268.1 - 0.022 14.8 0.1 0.051 13.7 0.1 1.5 1 0 0 1 1 1 0 WD repeat binding protein EZH2 CH PF00307.31 PIK47269.1 - 0.00034 20.8 0.0 0.0004 20.5 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain Apolipoprotein PF01442.18 PIK47270.1 - 4e-17 62.7 13.0 5.9e-17 62.2 13.0 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Gp58 PF07902.11 PIK47270.1 - 6.3e-09 34.7 16.2 7.8e-09 34.4 16.2 1.1 1 0 0 1 1 1 1 gp58-like protein DUF1103 PF06513.11 PIK47270.1 - 2e-07 30.9 24.2 2.4e-07 30.6 24.2 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) YtxH PF12732.7 PIK47270.1 - 5.7e-07 30.0 30.6 0.84 10.2 1.3 4.2 1 1 1 2 2 2 1 YtxH-like protein SF-assemblin PF06705.11 PIK47270.1 - 0.00011 21.6 14.2 0.0015 17.9 8.3 2.1 1 1 1 2 2 2 2 SF-assemblin/beta giardin OmpH PF03938.14 PIK47270.1 - 0.0003 21.1 22.9 0.006 16.9 4.7 3.0 1 1 1 3 3 3 2 Outer membrane protein (OmpH-like) TGS PF02824.21 PIK47270.1 - 0.00043 20.3 3.3 4.6 7.4 0.2 5.2 1 1 3 4 4 4 0 TGS domain AKAP7_NLS PF10469.9 PIK47270.1 - 0.0024 17.8 6.6 0.66 9.8 0.1 3.8 2 1 2 4 4 4 1 AKAP7 2'5' RNA ligase-like domain ZYG-11_interact PF05884.12 PIK47270.1 - 0.0025 17.3 7.7 4 6.8 7.7 3.1 1 1 0 1 1 1 0 Interactor of ZYG-11 HATPase_c_2 PF13581.6 PIK47270.1 - 0.0032 17.4 1.9 4.7 7.2 1.9 3.5 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Mer2 PF09074.10 PIK47270.1 - 0.0056 16.5 19.7 0.012 15.4 17.0 2.2 1 1 1 2 2 2 2 Mer2 DUF883 PF05957.13 PIK47270.1 - 0.0095 16.5 15.1 0.24 12.0 5.5 3.1 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 PIK47270.1 - 0.0098 15.5 7.9 0.012 15.2 7.9 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit ApoC-I PF04691.12 PIK47270.1 - 0.013 15.4 26.7 0.65 10.0 0.5 6.7 1 1 6 7 7 7 0 Apolipoprotein C-I (ApoC-1) Myb_CC_LHEQLE PF14379.6 PIK47270.1 - 0.014 15.1 4.6 13 5.6 0.0 4.7 1 1 3 4 4 4 0 MYB-CC type transfactor, LHEQLE motif Baculo_PEP_C PF04513.12 PIK47270.1 - 0.023 14.7 10.9 24 5.0 10.9 2.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF842 PF05811.13 PIK47270.1 - 0.034 13.9 7.5 0.24 11.1 2.2 2.4 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Prominin PF05478.11 PIK47270.1 - 0.049 11.6 10.8 0.081 10.9 10.0 1.4 1 1 0 1 1 1 0 Prominin DUF4510 PF14971.6 PIK47270.1 - 0.056 13.8 5.6 1.8 8.9 1.6 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4510) Focal_AT PF03623.13 PIK47270.1 - 0.058 13.4 8.7 0.2 11.6 4.8 2.5 1 1 2 3 3 3 0 Focal adhesion targeting region PLC-beta_C PF08703.10 PIK47270.1 - 0.085 12.8 19.0 0.089 12.8 4.9 3.3 1 1 1 2 2 2 0 PLC-beta C terminal ApoLp-III PF07464.11 PIK47270.1 - 0.098 12.7 24.3 4.4 7.4 24.1 2.4 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Mt_ATP-synt_B PF05405.14 PIK47270.1 - 0.11 12.1 14.4 1.3 8.6 1.9 3.2 1 1 2 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Utp12 PF04003.12 PIK47270.1 - 0.13 12.6 2.6 20 5.5 0.2 3.5 1 1 2 3 3 3 0 Dip2/Utp12 Family Peptidase_M75 PF09375.10 PIK47270.1 - 0.13 11.7 11.4 7.4 6.0 9.7 2.6 1 1 0 1 1 1 0 Imelysin Mitofilin PF09731.9 PIK47270.1 - 0.14 11.0 20.7 0.081 11.8 9.4 1.8 1 1 1 2 2 2 0 Mitochondrial inner membrane protein DUF4709 PF15821.5 PIK47270.1 - 0.18 12.1 9.9 0.49 10.7 3.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) Remorin_C PF03763.13 PIK47270.1 - 0.21 11.5 15.4 11 5.9 2.1 3.5 1 1 2 3 3 3 0 Remorin, C-terminal region CsgF PF10614.9 PIK47270.1 - 0.25 11.6 9.9 6.4 7.0 1.0 3.7 1 1 2 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein Transposase_24 PF03004.14 PIK47270.1 - 0.27 11.3 15.3 1.4 9.0 3.0 3.1 1 1 2 3 3 3 0 Plant transposase (Ptta/En/Spm family) REF PF05755.12 PIK47270.1 - 0.31 10.8 6.1 0.36 10.6 1.7 2.3 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) TOPRIM_C PF16898.5 PIK47270.1 - 0.47 10.7 7.7 16 5.8 0.5 3.4 1 1 3 4 4 4 0 C-terminal associated domain of TOPRIM V-ATPase_G_2 PF16999.5 PIK47270.1 - 0.54 10.7 11.7 5.2 7.5 2.2 2.8 1 1 2 3 3 3 0 Vacuolar (H+)-ATPase G subunit Fzo_mitofusin PF04799.13 PIK47270.1 - 0.73 9.4 14.8 1 8.9 5.5 2.6 1 1 2 3 3 3 0 fzo-like conserved region DFF40 PF09230.10 PIK47270.1 - 0.75 9.4 10.8 29 4.2 8.9 2.1 1 1 0 1 1 1 0 DNA fragmentation factor 40 kDa Mit_KHE1 PF10173.9 PIK47270.1 - 0.76 9.8 11.2 38 4.3 11.2 2.4 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Dynamin_M PF01031.20 PIK47270.1 - 0.79 8.9 13.9 0.66 9.1 5.8 2.0 1 1 1 2 2 2 0 Dynamin central region DUF4407 PF14362.6 PIK47270.1 - 0.89 8.8 14.0 1.2 8.4 14.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 PIK47270.1 - 1.1 8.0 11.3 1.3 7.7 11.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4854 PF16146.5 PIK47270.1 - 1.1 9.6 11.4 0.14 12.5 1.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4854) DUF4363 PF14276.6 PIK47270.1 - 1.2 9.3 9.2 0.94 9.6 3.0 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4363) FlaG PF03646.15 PIK47270.1 - 1.2 9.3 18.8 46 4.3 9.3 3.0 1 1 1 2 2 2 0 FlaG protein Tweety PF04906.13 PIK47270.1 - 1.4 7.5 9.7 3.1 6.4 2.9 2.3 1 1 1 2 2 2 0 Tweety Pepsin-I3 PF06394.13 PIK47270.1 - 1.4 9.1 9.7 28 5.0 0.1 4.4 3 1 2 5 5 4 0 Pepsin inhibitor-3-like repeated domain DUF445 PF04286.12 PIK47270.1 - 1.9 8.2 12.3 4.4 7.0 12.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) T3SS_needle_F PF09392.10 PIK47270.1 - 3.5 7.9 15.3 68 3.8 0.3 4.8 1 1 2 4 4 4 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Spectrin PF00435.21 PIK47270.1 - 3.6 8.1 18.0 5.2 7.6 12.2 2.5 1 1 1 2 2 2 0 Spectrin repeat RB_A PF01858.17 PIK47270.1 - 3.6 7.4 11.0 2 8.2 3.6 2.1 1 1 1 2 2 2 0 Retinoblastoma-associated protein A domain PIN_8 PF18476.1 PIK47270.1 - 5.8 6.7 15.0 4.1e+02 0.7 15.0 2.2 1 1 0 1 1 1 0 PIN like domain Ig_3 PF13927.6 PIK47271.1 - 4.7e-12 46.3 1.2 2.6e-07 31.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK47271.1 - 7.8e-10 39.0 0.5 0.0004 20.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK47271.1 - 8.8e-10 38.5 0.1 0.0002 21.4 0.0 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK47271.1 - 2.6e-08 34.1 0.2 0.0023 18.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin C1-set domain I-set PF07679.16 PIK47271.1 - 4.1e-07 30.0 0.0 0.00031 20.7 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK47271.1 - 4.1e-07 30.1 0.2 0.0096 16.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain zf-H2C2_2 PF13465.6 PIK47272.1 - 7.1e-38 127.4 77.9 4.7e-06 26.8 2.7 12.6 13 0 0 13 13 12 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK47272.1 - 3.4e-32 109.1 76.6 1.7e-05 25.0 0.3 11.3 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK47272.1 - 8.4e-23 79.1 76.2 0.0032 18.2 0.8 11.3 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK47272.1 - 6.7e-13 48.6 40.3 0.052 13.9 0.0 10.4 10 1 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK47272.1 - 2.8e-10 40.2 47.4 0.018 15.4 0.2 10.1 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK47272.1 - 8.8e-05 22.7 12.9 0.0012 19.1 2.8 7.3 7 1 0 8 8 8 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 PIK47272.1 - 0.089 12.6 0.1 0.089 12.6 0.1 8.0 10 0 0 10 10 10 0 zinc-finger C2H2-type DAG_kinase_N PF14513.6 PIK47272.1 - 0.17 12.1 0.1 0.17 12.1 0.1 2.6 3 1 0 3 3 3 0 Diacylglycerol kinase N-terminus zf-C2H2_3rep PF18868.1 PIK47272.1 - 0.37 11.5 32.7 8.5 7.1 8.9 6.7 3 2 3 6 6 5 0 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 PIK47272.1 - 0.51 10.0 0.0 0.51 10.0 0.0 6.0 4 1 2 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-trcl PF13451.6 PIK47272.1 - 0.8 9.7 0.0 0.8 9.7 0.0 8.0 8 1 0 8 8 7 0 Probable zinc-ribbon domain AT_hook PF02178.19 PIK47272.1 - 1.7 8.8 9.0 0.069 13.1 2.6 2.2 2 0 0 2 2 1 0 AT hook motif zf-C2H2_4 PF13894.6 PIK47273.1 - 6.6e-08 32.7 14.4 0.0096 16.7 1.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK47273.1 - 0.0034 17.8 19.8 0.013 16.0 0.1 4.1 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK47273.1 - 0.0055 17.1 22.3 0.14 12.7 1.2 4.1 4 0 0 4 4 4 3 Zinc-finger double domain CXCL17 PF15211.6 PIK47273.1 - 0.0063 17.2 9.6 0.016 15.9 9.6 1.7 1 0 0 1 1 1 1 VEGF co-regulated chemokine 1 zf-met PF12874.7 PIK47273.1 - 0.03 14.7 0.1 0.03 14.7 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Elf1 PF05129.13 PIK47273.1 - 0.039 14.0 14.1 0.85 9.7 8.0 3.3 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like ADK_lid PF05191.14 PIK47273.1 - 0.074 13.0 1.8 0.26 11.3 1.8 2.1 1 0 0 1 1 1 0 Adenylate kinase, active site lid PyrI_C PF02748.15 PIK47273.1 - 0.16 11.9 4.4 0.83 9.6 0.9 2.7 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PHD PF00628.29 PIK47273.1 - 0.25 11.3 7.3 0.32 10.9 1.4 2.7 2 0 0 2 2 2 0 PHD-finger zf_C2H2_ZHX PF18387.1 PIK47273.1 - 0.41 10.3 0.0 0.41 10.3 0.0 2.4 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_10 PF10058.9 PIK47273.1 - 0.46 10.3 2.8 7.2 6.4 0.0 3.1 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_2 PF12756.7 PIK47273.1 - 0.68 10.3 9.0 51 4.3 7.6 3.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) C1_2 PF03107.16 PIK47273.1 - 0.96 9.8 10.1 10 6.6 1.3 3.5 2 1 1 3 3 3 0 C1 domain zf-Di19 PF05605.12 PIK47273.1 - 2.6 8.4 13.3 1 9.7 4.9 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_4 PF13717.6 PIK47273.1 - 2.7 8.0 7.3 2.6 8.0 0.2 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_8 PF15909.5 PIK47273.1 - 2.8 8.3 8.9 5.2 7.4 1.6 2.7 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 PIK47274.1 - 1.7e-17 63.0 26.8 6.4e-07 29.5 0.6 4.3 5 0 0 5 5 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK47274.1 - 4.9e-12 45.6 24.7 9.2e-05 22.7 2.4 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK47274.1 - 2.3e-08 34.2 25.0 0.0035 18.1 1.8 4.4 5 0 0 5 5 4 3 C2H2-type zinc finger zf-met PF12874.7 PIK47274.1 - 4.7e-06 26.8 14.0 0.093 13.2 0.0 4.1 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK47274.1 - 5.5e-06 26.6 6.0 0.0017 18.6 2.4 2.4 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK47274.1 - 1.1e-05 25.5 7.4 2.5 8.5 0.8 4.4 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 PIK47274.1 - 6.4e-05 22.8 8.1 0.0012 18.7 2.5 2.4 2 0 0 2 2 2 1 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 PIK47274.1 - 0.00054 19.9 19.1 1 9.5 0.8 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK47274.1 - 0.0013 19.1 6.6 0.083 13.2 0.1 3.3 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) DZR PF12773.7 PIK47274.1 - 0.0063 16.5 5.7 0.12 12.5 5.7 2.2 1 1 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.10 PIK47274.1 - 0.0067 16.5 6.9 0.068 13.3 2.2 2.5 2 0 0 2 2 2 1 Zinc ribbon domain zf-BED PF02892.15 PIK47274.1 - 0.0088 16.0 11.3 0.52 10.4 3.5 3.3 1 1 2 3 3 3 1 BED zinc finger Zn_Tnp_IS1595 PF12760.7 PIK47274.1 - 0.0099 15.8 4.1 0.0099 15.8 4.1 2.1 2 0 0 2 2 2 1 Transposase zinc-ribbon domain DUF3268 PF11672.8 PIK47274.1 - 0.033 14.5 1.4 0.31 11.4 0.1 2.2 1 1 2 3 3 3 0 zinc-finger-containing domain Rtf2 PF04641.12 PIK47274.1 - 0.07 12.5 1.6 0.3 10.4 1.7 2.0 1 1 0 1 1 1 0 Rtf2 RING-finger zf-C2H2_3rep PF18868.1 PIK47274.1 - 0.081 13.6 4.7 4 8.1 1.6 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF629 PF04780.12 PIK47274.1 - 0.084 11.4 7.8 0.24 9.9 0.6 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF629) Actin_micro PF17003.5 PIK47274.1 - 0.085 12.0 5.4 0.056 12.6 2.0 2.0 1 1 1 2 2 2 0 Putative actin-like family Zn-C2H2_12 PF18112.1 PIK47274.1 - 0.097 13.2 1.9 0.33 11.4 0.1 2.7 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain Zf_RING PF16744.5 PIK47274.1 - 0.11 12.6 3.8 5.2 7.3 0.2 2.8 2 1 1 3 3 3 0 KIAA1045 RING finger zf-AN1 PF01428.16 PIK47274.1 - 0.12 12.5 5.8 4.5 7.5 0.2 3.3 3 0 0 3 3 3 0 AN1-like Zinc finger Ogr_Delta PF04606.12 PIK47274.1 - 0.19 11.7 8.0 1.3 9.1 1.5 2.5 1 1 1 2 2 2 0 Ogr/Delta-like zinc finger Evr1_Alr PF04777.13 PIK47274.1 - 0.27 11.7 5.8 2.6 8.6 1.2 2.5 1 1 1 2 2 2 0 Erv1 / Alr family zf-H2C2_5 PF13909.6 PIK47274.1 - 0.35 10.7 9.7 0.17 11.7 3.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain GAGA PF09237.11 PIK47274.1 - 0.36 10.7 6.1 1 9.2 0.3 3.0 1 1 2 3 3 3 0 GAGA factor zinc-ribbons_6 PF07191.12 PIK47274.1 - 0.41 10.6 5.4 2.6 8.1 0.8 2.6 1 1 2 3 3 3 0 zinc-ribbons FYDLN_acid PF09538.10 PIK47274.1 - 0.53 11.0 4.1 2.6 8.8 0.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-C2HE PF16278.5 PIK47274.1 - 0.8 10.2 9.4 10 6.6 0.5 3.2 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 PIK47274.1 - 1 9.0 3.9 2.3 7.9 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-trcl PF13451.6 PIK47274.1 - 1.1 9.2 5.5 5.9 6.9 3.4 2.7 2 1 0 2 2 2 0 Probable zinc-ribbon domain zf-C2HC_2 PF13913.6 PIK47274.1 - 1.6 8.7 10.4 0.15 12.0 1.2 2.8 3 0 0 3 3 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK47274.1 - 2.5 7.9 7.5 8.2 6.3 0.6 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type Rad50_zn_hook PF04423.14 PIK47274.1 - 2.9 7.8 5.8 1.4 8.8 0.4 2.6 2 1 1 3 3 3 0 Rad50 zinc hook motif FYVE PF01363.21 PIK47274.1 - 3.1 8.0 10.3 7.7 6.7 0.8 2.8 1 1 0 2 2 2 0 FYVE zinc finger zf-RING_5 PF14634.6 PIK47274.1 - 3.2 7.8 7.2 18 5.4 0.1 3.1 2 1 0 3 3 3 0 zinc-RING finger domain C1_4 PF07975.12 PIK47274.1 - 3.4 8.0 7.1 6.6 7.1 1.3 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain zf-CHY PF05495.12 PIK47274.1 - 6.1 7.4 10.4 10 6.7 5.8 2.4 1 1 0 2 2 2 0 CHY zinc finger zf-H2C2_2 PF13465.6 PIK47275.1 - 2e-42 141.8 97.7 1e-08 35.2 2.2 12.6 13 0 0 13 13 13 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK47275.1 - 7.8e-34 114.2 99.5 5.9e-06 26.5 0.7 11.7 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK47275.1 - 7.1e-29 98.0 94.6 4.7e-05 23.9 0.8 12.1 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK47275.1 - 1.8e-15 56.8 59.7 0.00072 19.8 0.1 10.4 10 0 0 10 10 10 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK47275.1 - 0.00073 19.5 0.4 0.00073 19.5 0.4 11.6 12 0 0 12 12 12 4 C2H2-type zinc finger TRAF6_Z2 PF18048.1 PIK47275.1 - 0.0055 16.8 1.7 0.0055 16.8 1.7 4.5 5 0 0 5 5 5 1 TNF receptor-associated factor 6 zinc finger 2 zf-H2C2_5 PF13909.6 PIK47275.1 - 0.0066 16.2 1.8 0.0066 16.2 1.8 10.4 10 3 0 10 10 10 4 C2H2-type zinc-finger domain zf-met PF12874.7 PIK47275.1 - 0.013 15.9 69.7 0.053 13.9 0.3 10.3 11 0 0 11 11 11 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK47275.1 - 0.71 10.7 46.8 0.76 10.6 2.9 6.8 4 2 2 6 6 6 0 zinc-ribbon family Ank_2 PF12796.7 PIK47276.1 - 2.4e-32 111.3 1.3 5e-13 49.4 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK47276.1 - 2.8e-32 110.7 0.9 1.4e-09 38.3 0.1 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK47276.1 - 1e-25 89.0 3.4 0.00011 22.5 0.0 6.1 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 PIK47276.1 - 1.4e-25 86.5 1.0 0.00071 19.8 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK47276.1 - 5.7e-25 87.1 5.1 3.2e-07 30.5 0.0 5.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Phage_tube PF04985.14 PIK47276.1 - 0.009 15.7 0.3 0.023 14.4 0.3 1.6 1 0 0 1 1 1 1 Phage tail tube protein FII Selenoprotein_S PF06936.11 PIK47277.1 - 8.7e-41 139.9 6.0 9.6e-41 139.7 6.0 1.0 1 0 0 1 1 1 1 Selenoprotein S (SelS) Methyltrn_RNA_4 PF09936.9 PIK47277.1 - 0.049 13.5 2.1 0.065 13.1 2.1 1.1 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase FxsA PF04186.13 PIK47277.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 1 1 2 2 2 0 FxsA cytoplasmic membrane protein EOS1 PF12326.8 PIK47277.1 - 0.2 11.6 1.2 0.26 11.2 1.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.17 PIK47277.1 - 1.9 7.1 6.7 2.4 6.9 6.7 1.1 1 0 0 1 1 1 0 Presenilin CCDC71L PF15374.6 PIK47277.1 - 2.5 7.3 10.4 3.1 7.0 10.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L MAP17 PF15807.5 PIK47277.1 - 2.7 8.3 8.0 1.5 9.0 5.9 1.6 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DEAD PF00270.29 PIK47278.1 - 2.8e-45 154.2 0.1 4.1e-45 153.7 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK47278.1 - 3.5e-29 101.4 2.2 2.3e-28 98.7 0.6 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK47278.1 - 7e-06 26.1 0.0 7.7e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UFC1 PF08694.11 PIK47279.1 - 2.3e-83 277.4 0.1 2.6e-83 277.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 PIK47279.1 - 0.032 13.9 0.0 0.05 13.2 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK47279.1 - 0.09 13.1 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 RWD domain Glyoxalase_3 PF13468.6 PIK47279.1 - 0.18 11.9 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain Fibrillarin PF01269.17 PIK47280.1 - 2.8e-107 357.0 0.0 3.5e-107 356.7 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 PIK47280.1 - 1.2e-05 25.2 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 PIK47280.1 - 0.012 15.2 0.0 0.03 13.9 0.0 1.6 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 PIK47280.1 - 0.015 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pkinase PF00069.25 PIK47282.1 - 5.5e-49 166.9 0.0 7.1e-49 166.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47282.1 - 2e-22 79.8 0.0 2.7e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 PIK47282.1 - 0.042 13.4 1.0 0.15 11.6 0.0 2.2 2 1 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 PIK47282.1 - 0.14 12.0 0.0 0.8 9.6 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family ORC6 PF05460.13 PIK47282.1 - 7.8 5.7 13.0 16 4.6 13.0 1.5 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ig_3 PF13927.6 PIK47283.1 - 9.1e-09 35.8 1.4 8.2e-05 23.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK47283.1 - 1.6e-06 28.2 0.6 9.6e-06 25.7 0.1 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK47283.1 - 2e-05 24.7 0.2 0.0097 16.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK47283.1 - 0.0011 19.2 8.6 0.31 11.4 0.1 4.1 3 2 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK47283.1 - 0.097 12.8 0.1 0.45 10.6 0.0 2.2 2 1 0 2 2 2 0 Immunoglobulin I-set domain EGF_3 PF12947.7 PIK47283.1 - 6.1 7.1 10.1 6.7 7.0 1.7 3.2 3 0 0 3 3 3 0 EGF domain Pkinase_Tyr PF07714.17 PIK47284.1 - 2.7e-45 154.7 0.0 3.3e-45 154.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47284.1 - 1.3e-19 70.6 0.0 2e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain EamA PF00892.20 PIK47285.1 - 0.00029 21.0 18.7 0.00029 21.0 18.7 2.0 2 0 0 2 2 2 1 EamA-like transporter family Macro_2 PF14519.6 PIK47287.1 - 8.7e-10 38.4 0.0 1.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Macro-like domain Macro PF01661.21 PIK47287.1 - 0.00012 22.1 0.0 0.0011 19.0 0.0 2.2 1 1 0 1 1 1 1 Macro domain F5_F8_type_C PF00754.25 PIK47288.1 - 4e-24 85.1 0.0 2.6e-08 34.1 0.0 3.5 3 0 0 3 3 3 3 F5/8 type C domain Kringle PF00051.18 PIK47288.1 - 1.6e-09 37.9 2.7 9.1e-09 35.5 2.7 2.4 1 0 0 1 1 1 1 Kringle domain FXa_inhibition PF14670.6 PIK47288.1 - 1.2e-08 35.1 9.1 3.8e-08 33.5 9.1 2.0 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK47288.1 - 3.8e-08 33.4 9.6 3.8e-08 33.4 9.6 2.7 2 0 0 2 2 2 1 Calcium-binding EGF domain EGF PF00008.27 PIK47288.1 - 0.00026 21.2 9.1 0.00026 21.2 9.1 3.1 3 0 0 3 3 3 1 EGF-like domain Lectin_C PF00059.21 PIK47288.1 - 0.011 16.5 5.3 0.61 10.8 0.3 3.7 2 1 1 3 3 3 0 Lectin C-type domain cEGF PF12662.7 PIK47288.1 - 0.011 15.7 8.2 0.014 15.3 2.2 3.5 3 0 0 3 3 3 0 Complement Clr-like EGF-like SIP PF04954.13 PIK47288.1 - 0.072 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting protein Plasmod_Pvs28 PF06247.11 PIK47288.1 - 0.15 12.4 4.8 0.74 10.2 4.8 2.3 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_3 PF12947.7 PIK47288.1 - 0.2 11.9 5.5 1.2 9.3 5.5 2.5 1 0 0 1 1 1 0 EGF domain CUB PF00431.20 PIK47289.1 - 5.3e-25 87.9 1.0 1.1e-08 35.4 0.0 3.3 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.20 PIK47289.1 - 3.4e-06 26.8 1.2 0.0025 17.6 0.1 3.3 3 0 0 3 3 3 2 CUB-like domain Lectin_C PF00059.21 PIK47289.1 - 0.0063 17.2 0.0 0.022 15.5 0.0 1.9 1 0 0 1 1 1 1 Lectin C-type domain NaeI PF09126.10 PIK47290.1 - 0.059 12.6 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease NaeI 7tm_2 PF00002.24 PIK47292.1 - 7.8e-36 123.6 16.3 1.1e-35 123.1 16.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HYR PF02494.16 PIK47292.1 - 6.3e-15 55.3 18.5 3.8e-08 33.6 4.4 3.0 2 0 0 2 2 2 2 HYR domain MIEAP PF16026.5 PIK47292.1 - 0.16 12.2 0.8 0.49 10.6 0.2 2.1 2 0 0 2 2 2 0 Mitochondria-eating protein Peptidase_M18 PF02127.15 PIK47293.1 - 7.6e-126 420.4 0.2 1.5e-89 300.8 0.0 2.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 PIK47293.1 - 2.3e-08 33.4 0.1 0.00019 20.6 0.1 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Condensin2nSMC PF12422.8 PIK47294.1 - 1.7e-42 145.1 0.7 7.3e-36 123.6 0.0 3.0 3 0 0 3 3 3 2 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 PIK47294.1 - 2.8e-08 33.3 0.5 0.027 14.7 0.1 4.0 3 0 0 3 3 3 3 HEAT repeat Cnd1 PF12717.7 PIK47294.1 - 0.0024 17.9 2.2 0.0094 16.0 0.0 2.8 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK47294.1 - 0.0069 16.8 0.1 0.13 12.7 0.1 2.9 2 1 2 4 4 4 2 HEAT repeats CLASP_N PF12348.8 PIK47294.1 - 0.039 13.5 0.1 1.5 8.4 0.0 2.9 2 1 0 2 2 2 0 CLASP N terminal Adaptin_N PF01602.20 PIK47294.1 - 0.095 11.2 1.1 0.53 8.8 0.1 2.3 2 1 1 3 3 3 0 Adaptin N terminal region HEAT_EZ PF13513.6 PIK47294.1 - 0.11 13.1 0.2 0.45 11.1 0.1 2.2 2 0 0 2 2 2 0 HEAT-like repeat Big_4 PF07532.11 PIK47296.1 - 0.061 13.1 1.7 4.6 7.1 0.0 3.5 3 1 1 4 4 4 0 Bacterial Ig-like domain (group 4) Tsi6 PF18660.1 PIK47297.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Tsi6 fn3 PF00041.21 PIK47298.1 - 7e-07 29.5 1.0 1.5e-06 28.4 0.6 1.7 2 0 0 2 2 2 1 Fibronectin type III domain LRR_8 PF13855.6 PIK47299.1 - 9.2e-37 124.6 21.7 6.2e-08 32.3 0.0 7.4 3 2 6 9 9 9 8 Leucine rich repeat LRR_5 PF13306.6 PIK47299.1 - 2.3e-26 92.3 4.6 3.9e-08 33.3 0.7 4.1 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK47299.1 - 4.4e-13 49.2 21.3 0.00013 22.3 0.1 8.2 5 2 3 8 8 8 4 Leucine Rich repeats (2 copies) Ephrin_rec_like PF07699.13 PIK47299.1 - 0.002 17.9 2.9 0.002 17.9 2.9 4.7 2 1 1 4 4 4 2 Putative ephrin-receptor like TRP PF06011.12 PIK47299.1 - 0.0096 14.7 17.5 0.019 13.7 17.5 1.5 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel LRR_9 PF14580.6 PIK47299.1 - 0.0097 15.4 6.9 0.2 11.1 0.0 3.8 2 2 3 5 5 5 1 Leucine-rich repeat LRR_6 PF13516.6 PIK47299.1 - 0.025 14.6 0.6 24 5.3 0.0 4.9 3 0 0 3 3 3 0 Leucine Rich repeat DUF3302 PF11742.8 PIK47299.1 - 0.14 12.3 1.2 0.36 11.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) DUF2700 PF10912.8 PIK47299.1 - 0.62 10.1 10.1 0.18 11.8 4.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2700) LRR_1 PF00560.33 PIK47299.1 - 0.72 10.6 16.1 45 5.2 0.1 8.6 9 1 0 9 9 9 0 Leucine Rich Repeat fn3 PF00041.21 PIK47300.1 - 4.4e-14 52.6 0.9 2.7e-07 30.8 0.0 3.2 3 0 0 3 3 3 2 Fibronectin type III domain fn3 PF00041.21 PIK47301.1 - 1.2e-15 57.6 0.6 1.4e-09 38.1 0.2 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 PIK47301.1 - 0.013 15.8 0.1 0.82 10.0 0.1 2.8 2 1 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF4330 PF14221.6 PIK47301.1 - 0.092 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) CarboxypepD_reg PF13620.6 PIK47301.1 - 0.098 12.9 0.2 0.21 11.9 0.2 1.5 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DUF2500 PF10694.9 PIK47301.1 - 0.13 12.8 0.1 0.73 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) DUF3522 PF12036.8 PIK47303.1 - 2.7e-53 181.1 21.2 4.2e-53 180.4 21.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) TssN PF17555.2 PIK47303.1 - 0.021 14.2 0.5 0.021 14.2 0.5 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN DUF3671 PF12420.8 PIK47303.1 - 2 8.5 4.7 9.3 6.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF4491 PF14898.6 PIK47303.1 - 3.5 8.1 7.1 0.43 11.1 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) WD40 PF00400.32 PIK47304.1 - 5.6e-12 46.0 20.1 0.028 15.3 3.7 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat F-box-like PF12937.7 PIK47304.1 - 6.6e-09 35.5 0.5 1.3e-08 34.5 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK47304.1 - 1.2e-07 31.4 0.3 3.5e-07 29.9 0.3 1.8 1 0 0 1 1 1 1 F-box domain PQQ_3 PF13570.6 PIK47304.1 - 0.0021 18.5 0.0 0.022 15.3 0.0 2.5 3 0 0 3 3 3 1 PQQ-like domain F-box_4 PF15966.5 PIK47304.1 - 0.0026 17.7 0.7 0.026 14.4 0.0 2.4 2 0 0 2 2 2 1 F-box HEAT PF02985.22 PIK47305.1 - 5.1e-27 91.6 10.9 0.0021 18.2 0.0 11.2 11 0 0 11 11 11 6 HEAT repeat HEAT_EZ PF13513.6 PIK47305.1 - 2.7e-26 91.6 4.8 1.7e-07 31.6 0.0 11.2 9 3 3 12 12 11 5 HEAT-like repeat HEAT_2 PF13646.6 PIK47305.1 - 4e-16 59.2 0.0 0.02 15.3 0.1 7.3 5 3 1 6 6 6 4 HEAT repeats Arm PF00514.23 PIK47305.1 - 1.6e-12 47.0 5.8 0.02 14.9 0.0 7.0 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 PIK47305.1 - 6.9e-11 42.5 0.2 0.032 14.3 0.0 4.7 4 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK47305.1 - 1.3e-10 41.8 0.3 0.044 14.4 0.0 6.3 5 2 2 7 7 7 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 PIK47305.1 - 3.4e-06 26.9 0.0 3.3e-05 23.7 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain MMS19_C PF12460.8 PIK47305.1 - 2.1e-05 23.8 4.0 4.6 6.3 0.1 5.8 5 2 0 6 6 6 1 RNAPII transcription regulator C-terminal Xpo1 PF08389.12 PIK47305.1 - 0.0005 20.2 1.3 1.1 9.3 0.0 4.0 4 0 0 4 4 4 1 Exportin 1-like protein DUF3689 PF12463.8 PIK47305.1 - 0.0035 16.7 0.1 0.028 13.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3689) DUF3437 PF11919.8 PIK47305.1 - 0.056 13.4 0.1 0.6 10.1 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) TAFH PF07531.14 PIK47305.1 - 0.07 13.2 1.9 28 4.9 0.0 4.3 4 1 1 5 5 5 0 NHR1 homology to TAF GOLD_2 PF13897.6 PIK47306.1 - 0.0009 19.7 0.4 0.0017 18.9 0.2 1.4 1 1 0 1 1 1 1 Golgi-dynamics membrane-trafficking D_CNTX PF17492.2 PIK47306.1 - 0.02 15.1 2.3 0.021 15.0 0.1 2.0 2 0 0 2 2 2 0 Delta Ctenitoxins I_LWEQ PF01608.17 PIK47307.1 - 1e-52 178.5 8.8 1e-52 178.5 8.8 3.3 3 1 1 4 4 4 1 I/LWEQ domain HIP1_clath_bdg PF16515.5 PIK47307.1 - 0.00011 22.8 7.8 0.00011 22.8 7.8 3.5 4 0 0 4 4 4 2 Clathrin-binding domain of Huntingtin-interacting protein 1 Acyl-CoA_dh_2 PF08028.11 PIK47307.1 - 0.65 10.3 8.6 4.7 7.5 0.7 2.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain ANTH PF07651.16 PIK47308.1 - 4.7e-09 35.6 0.1 9e-09 34.7 0.1 1.3 1 0 0 1 1 1 1 ANTH domain PHINT_rpt PF14882.6 PIK47308.1 - 0.17 12.2 0.2 0.31 11.4 0.2 1.4 1 0 0 1 1 1 0 Phage-integrase repeat unit Spc29 PF17082.5 PIK47308.1 - 0.84 9.4 6.2 0.47 10.2 4.2 1.5 2 0 0 2 2 2 0 Spindle Pole Component 29 HYR PF02494.16 PIK47309.1 - 1.3e-210 682.4 60.6 2.3e-23 82.3 1.1 11.5 11 0 0 11 11 11 11 HYR domain EGF PF00008.27 PIK47309.1 - 2.1e-43 146.2 209.3 5.8e-08 32.9 7.2 15.6 14 1 0 14 14 14 13 EGF-like domain hEGF PF12661.7 PIK47309.1 - 2e-17 63.1 175.7 0.00049 20.6 9.5 16.5 15 0 0 15 15 15 9 Human growth factor-like EGF PA_decarbox PF05870.11 PIK47309.1 - 4.9e-05 23.0 2.0 5.8 6.5 0.0 5.7 8 0 0 8 8 8 1 Phenolic acid decarboxylase (PAD) PhnG PF06754.12 PIK47309.1 - 0.067 13.1 0.1 32 4.5 0.0 4.1 5 0 0 5 5 5 0 Phosphonate metabolism protein PhnG PASTA PF03793.19 PIK47309.1 - 0.21 11.5 2.0 13 5.7 0.1 2.9 2 0 0 2 2 2 0 PASTA domain Cadherin_3 PF16184.5 PIK47309.1 - 6.3 6.8 8.1 9.8 6.2 0.1 4.2 5 0 0 5 5 5 0 Cadherin-like Tcf25 PF04910.14 PIK47310.1 - 2.7e-112 375.3 2.8 3.5e-112 374.9 2.8 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Stm1_N PF09598.10 PIK47310.1 - 0.0018 19.0 3.7 0.0058 17.5 3.7 1.8 1 0 0 1 1 1 1 Stm1 HSF_DNA-bind PF00447.17 PIK47311.1 - 1.4e-22 80.1 0.4 3.3e-22 78.9 0.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding EMP24_GP25L PF01105.24 PIK47311.1 - 0.14 12.0 0.9 1.1 9.1 0.3 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD p450 PF00067.22 PIK47312.1 - 3e-92 309.8 0.0 3.3e-92 309.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HVSL PF09749.9 PIK47313.1 - 1.6e-48 165.3 0.0 1.9e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 PIK47313.1 - 4.7e-05 23.4 0.0 0.018 14.9 0.0 2.1 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily DUF913 PF06025.12 PIK47314.1 - 0.051 12.6 14.4 0.34 9.8 5.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) LAP1C PF05609.12 PIK47314.1 - 0.1 11.7 21.7 0.13 11.3 21.7 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Fmp27_SW PF10305.9 PIK47314.1 - 0.32 11.7 0.2 0.32 11.7 0.2 3.0 3 0 0 3 3 1 0 RNA pol II promoter Fmp27 protein domain Orf78 PF06024.12 PIK47314.1 - 0.64 10.4 8.8 2.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Orf78 (ac78) MecA PF05389.12 PIK47314.1 - 1 8.9 19.3 0.49 10.0 1.5 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF2370 PF10176.9 PIK47314.1 - 1.6 8.3 3.5 42 3.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) CSG2 PF16965.5 PIK47314.1 - 2.4 7.0 9.0 5.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator DUF868 PF05910.12 PIK47314.1 - 4.5 6.8 10.5 1 8.9 0.4 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF868) TRAP_alpha PF03896.16 PIK47314.1 - 6.6 5.8 22.1 0.31 10.2 1.5 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PIP5K PF01504.18 PIK47314.1 - 7.3 5.7 21.4 0.22 10.7 1.7 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 PIK47314.1 - 7.4 5.5 18.6 0.27 10.2 0.6 2.0 2 0 0 2 2 2 0 CLN3 protein HYR PF02494.16 PIK47315.1 - 1.1e-47 160.2 11.7 1.2e-22 80.0 0.2 3.3 3 0 0 3 3 3 3 HYR domain HYR PF02494.16 PIK47316.1 - 3.7e-34 116.9 9.8 2e-17 63.3 0.5 3.2 3 0 0 3 3 3 2 HYR domain Big_8 PF17961.1 PIK47316.1 - 0.0013 18.9 0.2 1.2 9.3 0.0 2.5 2 0 0 2 2 2 2 Bacterial Ig domain DUF5011 PF16403.5 PIK47316.1 - 0.015 15.4 0.1 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Peptidase_S10 PF00450.22 PIK47317.1 - 6.1e-111 371.8 0.1 7.3e-111 371.5 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase ACP53EA PF06313.11 PIK47317.1 - 0.03 14.5 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Drosophila ACP53EA protein SAP PF02037.27 PIK47318.1 - 1.8e-12 46.7 2.0 3.1e-12 45.9 2.0 1.5 1 0 0 1 1 1 1 SAP domain CFAP91 PF14738.6 PIK47318.1 - 0.015 15.4 8.1 0.032 14.3 8.1 1.5 1 1 0 1 1 1 0 Cilia- and flagella-associated protein 91 Telomere_Sde2_2 PF13297.6 PIK47318.1 - 0.066 12.9 1.2 0.17 11.5 1.2 1.7 1 1 0 1 1 1 0 Telomere stability C-terminal RSB_motif PF16294.5 PIK47319.1 - 8.8e-19 67.7 21.8 8.8e-19 67.7 21.8 12.1 3 3 8 11 11 11 1 RNSP1-SAP18 binding (RSB) motif RRM_1 PF00076.22 PIK47319.1 - 0.016 15.0 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DASH_Dad1 PF08649.10 PIK47320.1 - 0.95 9.7 0.0 0.95 9.7 0.0 3.4 4 0 0 4 4 4 0 DASH complex subunit Dad1 DUF3361 PF11841.8 PIK47323.1 - 1.7e-45 154.7 0.9 4e-45 153.5 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 PIK47323.1 - 7.3e-39 133.7 1.6 1.5e-38 132.6 1.6 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 PIK47323.1 - 3.1e-29 102.2 0.0 7.1e-29 101.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Mcp5_PH PF12814.7 PIK47323.1 - 0.042 14.0 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology IBN_N PF03810.19 PIK47323.1 - 0.095 12.6 0.4 0.84 9.6 0.2 2.6 2 0 0 2 2 2 0 Importin-beta N-terminal domain bZIP_Maf PF03131.17 PIK47324.1 - 2.3e-26 92.1 10.5 4.3e-26 91.2 10.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 PIK47324.1 - 0.00041 20.4 10.7 0.00041 20.4 10.7 2.7 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK47324.1 - 0.015 15.4 10.8 0.03 14.4 9.8 2.0 1 1 1 2 2 2 0 bZIP transcription factor FHA PF00498.26 PIK47325.1 - 0.025 14.9 0.0 0.033 14.5 0.0 1.4 1 1 0 1 1 1 0 FHA domain Defensin_beta PF00711.19 PIK47325.1 - 0.037 14.0 1.4 0.065 13.3 1.4 1.4 1 0 0 1 1 1 0 Beta defensin HYR PF02494.16 PIK47326.1 - 1.7e-119 390.4 29.6 9.5e-24 83.5 0.1 6.0 6 0 0 6 6 6 6 HYR domain PA_decarbox PF05870.11 PIK47326.1 - 0.0024 17.5 0.2 1.1 8.8 0.0 3.7 4 0 0 4 4 4 1 Phenolic acid decarboxylase (PAD) DUF5011 PF16403.5 PIK47326.1 - 0.11 12.7 0.2 39 4.5 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF5011) HYR PF02494.16 PIK47327.1 - 6.9e-85 279.5 22.5 2.1e-24 85.6 0.1 4.0 4 0 0 4 4 4 4 HYR domain DUF5011 PF16403.5 PIK47327.1 - 0.0015 18.7 0.1 3.8 7.7 0.0 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF5011) PA_decarbox PF05870.11 PIK47327.1 - 0.0032 17.1 0.1 0.73 9.5 0.0 3.3 3 0 0 3 3 3 1 Phenolic acid decarboxylase (PAD) HYR PF02494.16 PIK47328.1 - 1.2e-14 54.4 0.0 1.8e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 HYR domain EGF PF00008.27 PIK47328.1 - 0.00046 20.4 7.0 0.00064 20.0 5.8 1.8 2 0 0 2 2 2 1 EGF-like domain DUF3827 PF12877.7 PIK47328.1 - 0.017 13.5 0.7 0.026 12.9 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) EGF_2 PF07974.13 PIK47328.1 - 0.027 14.8 6.4 0.056 13.8 6.4 1.5 1 0 0 1 1 1 0 EGF-like domain Cys_rich_VLP PF14194.6 PIK47328.1 - 0.066 13.3 1.3 0.12 12.5 1.3 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP hEGF PF12661.7 PIK47328.1 - 0.096 13.4 3.7 0.096 13.4 3.7 3.0 3 0 0 3 3 3 0 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK47328.1 - 0.52 10.6 5.6 1.4 9.3 5.6 1.7 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site L31 PF09784.9 PIK47330.1 - 1.4 9.4 9.3 3 8.3 0.9 4.1 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L31 SCAPER_N PF16501.5 PIK47330.1 - 1.7 8.7 5.2 3.9 7.6 0.1 3.4 3 0 0 3 3 3 0 S phase cyclin A-associated protein in the endoplasmic reticulum Laminin_EGF PF00053.24 PIK47332.1 - 2.4e-05 24.4 14.8 2.4e-05 24.4 14.8 7.0 2 2 4 6 6 6 2 Laminin EGF domain EGF_2 PF07974.13 PIK47332.1 - 0.0018 18.6 99.2 0.073 13.5 16.1 10.1 5 5 3 8 8 8 5 EGF-like domain Amidohydro_3 PF07969.11 PIK47333.1 - 1.1e-06 28.4 0.0 1.3e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK47334.1 - 1.5e-19 70.9 0.0 1.7e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK47335.1 - 1.8e-17 64.0 0.0 2.6e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family AAA_10 PF12846.7 PIK47336.1 - 0.0031 16.5 0.0 0.0034 16.3 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain Pkinase_Tyr PF07714.17 PIK47339.1 - 1.1e-25 90.4 0.2 1.1e-22 80.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK47339.1 - 1.6e-07 31.0 0.1 2.5e-06 27.1 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain TK PF00265.18 PIK47339.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase NACHT PF05729.12 PIK47340.1 - 1.1e-06 28.6 0.2 3.2e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK47340.1 - 0.023 14.7 1.3 0.057 13.5 1.3 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF4871 PF16167.5 PIK47340.1 - 0.033 14.2 0.4 0.094 12.7 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4871) C1-set PF07654.15 PIK47340.1 - 0.042 14.2 4.7 0.05 14.0 2.7 2.2 2 0 0 2 2 2 0 Immunoglobulin C1-set domain LapA_dom PF06305.11 PIK47340.1 - 0.049 13.4 2.5 4.2 7.3 0.4 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Insulin_TMD PF17870.1 PIK47340.1 - 0.15 12.1 0.8 0.33 11.1 0.8 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4519 PF15012.6 PIK47340.1 - 8.1 6.7 6.5 32 4.8 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Pkinase_Tyr PF07714.17 PIK47341.1 - 3.8e-36 124.7 0.0 6.8e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47341.1 - 7.2e-17 61.6 0.0 2e-16 60.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Ig_3 PF13927.6 PIK47341.1 - 5.6e-09 36.5 2.3 0.0013 19.3 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain DUF5305 PF17231.2 PIK47341.1 - 0.0029 17.0 0.0 0.0029 17.0 0.0 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF5305) I-set PF07679.16 PIK47341.1 - 0.0041 17.2 0.1 0.37 10.9 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain RVT_1 PF00078.27 PIK47342.1 - 3.1e-14 53.0 0.2 1.1e-13 51.3 0.2 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK47343.1 - 4.9e-13 49.3 0.0 7.7e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK47343.1 - 0.0018 18.0 0.0 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Retrotrans_gag PF03732.17 PIK47344.1 - 0.0005 20.3 0.1 0.0051 17.1 0.0 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein SCAN PF02023.17 PIK47344.1 - 0.0038 17.0 0.0 0.0074 16.1 0.0 1.5 1 0 0 1 1 1 1 SCAN domain Ig_3 PF13927.6 PIK47345.1 - 1.7e-11 44.5 1.7 6.2e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK47345.1 - 0.00024 21.1 0.2 0.013 15.5 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK47345.1 - 0.0012 19.2 2.6 0.023 15.0 0.5 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Marek_A PF02124.15 PIK47345.1 - 0.011 15.6 0.4 0.019 14.8 0.3 1.6 1 1 0 1 1 1 0 Marek's disease glycoprotein A C1-set PF07654.15 PIK47345.1 - 0.11 12.9 2.1 0.18 12.2 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin C1-set domain zf-CCHC PF00098.23 PIK47346.1 - 7.8e-07 28.9 20.3 0.00022 21.1 3.0 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK47346.1 - 0.0056 16.6 4.0 0.0056 16.6 4.0 2.8 1 1 1 2 2 2 1 Zinc knuckle Pkinase_Tyr PF07714.17 PIK47347.1 - 2.8e-12 46.5 0.8 4e-12 46.0 0.8 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47347.1 - 2.6e-07 30.3 0.7 3.8e-07 29.7 0.7 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47349.1 - 1.1e-19 70.7 0.0 1.4e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47349.1 - 3.7e-12 46.2 0.0 4.6e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK47350.1 - 0.0014 19.2 0.1 0.11 13.1 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK47350.1 - 0.0018 18.4 0.1 0.25 11.5 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK47350.1 - 0.02 15.0 0.0 0.094 12.9 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK47350.1 - 0.059 13.4 0.0 0.75 9.9 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin I-set domain NACHT PF05729.12 PIK47351.1 - 4.4e-07 30.0 0.1 2.1e-06 27.8 0.1 1.9 1 1 1 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK47351.1 - 1.3e-05 25.5 0.0 2.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK47351.1 - 0.00012 22.1 0.1 0.00046 20.2 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 PIK47351.1 - 0.0013 19.1 0.0 0.0018 18.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK47351.1 - 0.0036 17.7 0.0 0.0072 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 PIK47351.1 - 0.004 16.9 0.0 0.0066 16.2 0.0 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein Peptidase_S41 PF03572.18 PIK47351.1 - 0.0087 15.6 0.0 0.018 14.6 0.0 1.4 1 1 0 1 1 1 1 Peptidase family S41 Bac_DnaA PF00308.18 PIK47351.1 - 0.0092 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_7 PF12775.7 PIK47351.1 - 0.0097 15.4 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 PIK47351.1 - 0.015 15.8 0.3 0.031 14.8 0.3 1.6 1 1 0 1 1 1 0 ABC transporter Aminotran_5 PF00266.19 PIK47351.1 - 0.021 13.8 0.0 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V AAA_24 PF13479.6 PIK47351.1 - 0.057 13.1 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 PIK47351.1 - 0.13 11.7 0.1 0.87 9.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein Pkinase_Tyr PF07714.17 PIK47352.1 - 5.6e-24 84.8 0.0 7.2e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47352.1 - 0.0011 18.4 0.1 0.0016 17.9 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Y_phosphatase PF00102.27 PIK47353.1 - 1.7e-06 27.8 0.0 2.7e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF5622 PF18533.1 PIK47353.1 - 0.066 13.4 0.0 0.27 11.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5622) RT_RNaseH_2 PF17919.1 PIK47355.1 - 4.1e-15 55.6 0.0 6.2e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47355.1 - 0.00028 21.1 0.0 0.00048 20.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase fn3 PF00041.21 PIK47356.1 - 4.1e-13 49.5 1.3 1.9e-07 31.3 0.9 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK47356.1 - 3e-05 24.5 2.6 0.0038 17.8 2.0 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain REJ PF02010.15 PIK47356.1 - 0.0014 17.6 0.5 0.0038 16.1 0.5 1.7 1 1 0 1 1 1 1 REJ domain TMEM154 PF15102.6 PIK47356.1 - 0.002 18.1 1.6 0.0042 17.0 1.6 1.6 1 0 0 1 1 1 1 TMEM154 protein family Amnionless PF14828.6 PIK47356.1 - 0.01 14.7 0.2 0.014 14.3 0.2 1.2 1 0 0 1 1 1 0 Amnionless GPI-anchored PF10342.9 PIK47356.1 - 0.011 16.5 4.1 0.045 14.5 2.6 2.2 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF5383 PF17355.2 PIK47356.1 - 0.016 15.6 0.9 0.028 14.8 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DUF4448 PF14610.6 PIK47356.1 - 0.019 14.8 0.1 0.027 14.3 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) RIFIN PF02009.16 PIK47356.1 - 0.025 14.5 0.3 0.025 14.5 0.3 1.2 1 0 0 1 1 1 0 Rifin DUF5305 PF17231.2 PIK47356.1 - 0.057 12.8 5.4 0.05 13.0 3.9 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5305) DUF2207 PF09972.9 PIK47356.1 - 0.12 11.1 2.4 0.44 9.2 1.2 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 PIK47356.1 - 0.14 12.5 1.7 0.26 11.6 1.7 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Podoplanin PF05808.11 PIK47356.1 - 0.29 11.2 7.3 0.44 10.6 7.3 1.3 1 0 0 1 1 1 0 Podoplanin Endomucin PF07010.12 PIK47356.1 - 0.93 9.4 8.6 1.4 8.8 8.4 1.4 1 1 0 1 1 1 0 Endomucin Y_phosphatase PF00102.27 PIK47357.1 - 4.4e-84 281.7 5.9 1e-58 198.7 2.5 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK47357.1 - 6.7e-05 22.7 0.3 0.00022 21.0 0.2 1.9 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK47357.1 - 0.0002 21.4 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK47357.1 - 0.0026 17.9 0.1 0.052 13.7 0.0 2.8 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK47357.1 - 0.013 15.1 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK47358.1 - 1.2e-29 103.6 0.4 1.3e-29 103.4 0.4 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK47358.1 - 0.027 14.3 0.1 0.046 13.5 0.1 1.6 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RVT_1 PF00078.27 PIK47359.1 - 2e-06 27.5 0.0 3.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Y_phosphatase PF00102.27 PIK47360.1 - 5.6e-94 314.1 0.5 1.8e-48 165.1 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK47360.1 - 1.1e-06 28.5 0.1 0.0038 17.0 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK47360.1 - 0.011 15.9 0.4 1.1 9.4 0.0 3.6 4 0 0 4 4 4 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 PIK47362.1 - 7.3e-83 277.7 0.6 4.8e-42 144.1 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK47362.1 - 2.8e-06 27.2 0.1 0.0057 16.5 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK47362.1 - 0.0021 18.2 0.2 0.46 10.6 0.0 3.6 4 0 0 4 4 4 1 Inositol hexakisphosphate Phage_glycop_gL PF11108.8 PIK47362.1 - 0.017 15.1 0.0 7.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Viral glycoprotein L Y_phosphatase3 PF13350.6 PIK47362.1 - 0.082 12.9 0.0 2 8.3 0.0 2.2 2 0 0 2 2 2 0 Tyrosine phosphatase family Orbi_VP5 PF00901.17 PIK47363.1 - 0.00017 20.1 0.0 0.1 11.0 0.0 2.2 1 1 1 2 2 2 2 Orbivirus outer capsid protein VP5 DUF753 PF05444.12 PIK47363.1 - 0.0012 18.8 25.5 0.088 12.8 7.2 3.1 2 1 1 3 3 3 2 Protein of unknown function (DUF753) LPD28 PF18843.1 PIK47363.1 - 0.011 15.3 0.0 5.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Large polyvalent protein associated domain 28 Plasmo_rep PF12135.8 PIK47363.1 - 0.021 14.4 0.5 61 3.3 0.0 3.8 3 0 0 3 3 3 0 Plasmodium repeat family Rota_NSP3 PF01665.16 PIK47363.1 - 0.19 10.8 0.0 20 4.2 0.0 2.5 2 2 0 2 2 2 0 Rotavirus non-structural protein NSP3 Rad50_zn_hook PF04423.14 PIK47363.1 - 0.26 11.2 4.1 11 6.0 0.3 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif motB PF17613.2 PIK47363.1 - 0.35 10.7 2.6 15 5.4 0.2 2.1 2 0 0 2 2 2 0 Modifier of transcription P22_AR_C PF10548.9 PIK47364.1 - 0.009 16.2 0.5 0.024 14.8 0.1 2.0 3 0 0 3 3 3 1 P22AR C-terminal domain CLZ PF16526.5 PIK47364.1 - 0.41 11.0 3.7 0.63 10.4 0.3 2.9 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pam16 PF03656.13 PIK47366.1 - 1.7e-41 141.2 5.0 2.2e-41 140.8 5.0 1.1 1 0 0 1 1 1 1 Pam16 EccE PF11203.8 PIK47366.1 - 0.0073 16.6 1.1 0.015 15.6 0.8 1.6 1 1 1 2 2 2 1 Putative type VII ESX secretion system translocon, EccE HTH_17 PF12728.7 PIK47366.1 - 0.022 14.9 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain PID PF00640.23 PIK47366.1 - 0.085 12.9 0.4 0.31 11.1 0.1 1.9 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) zf-C2H2 PF00096.26 PIK47367.1 - 4.9e-13 48.7 43.7 0.00023 21.5 1.2 5.8 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK47367.1 - 1.7e-10 40.8 47.7 9e-07 29.1 0.5 5.7 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK47367.1 - 1.5e-07 31.6 37.9 0.0055 17.4 0.5 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 PIK47367.1 - 4.5e-05 24.0 20.3 0.038 14.6 0.6 4.2 2 2 2 4 4 4 2 FOXP coiled-coil domain CCAP PF11105.8 PIK47367.1 - 0.021 14.8 3.6 0.53 10.3 0.2 2.3 2 0 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf-C2H2_11 PF16622.5 PIK47367.1 - 0.049 13.4 5.8 0.24 11.2 1.4 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 PIK47367.1 - 1.1 9.4 18.0 1.8 8.7 0.5 4.1 1 1 1 2 2 2 0 Aberrant zinc-finger Zap1_zf2 PF18217.1 PIK47367.1 - 2.1 8.4 12.9 1.9 8.6 6.2 3.2 2 1 0 2 2 2 0 Zap1 zinc finger 2 zf-met PF12874.7 PIK47367.1 - 2.2 8.8 16.1 3.1 8.3 0.2 3.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type WD40 PF00400.32 PIK47368.1 - 8.9e-32 108.6 20.1 1e-07 32.5 0.0 10.6 12 0 0 12 12 12 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK47368.1 - 1.7e-21 76.3 0.0 0.0027 18.0 0.0 9.1 3 2 7 10 10 10 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 PIK47368.1 - 2.4e-17 63.2 0.4 4.2e-17 62.4 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 PIK47368.1 - 3.6e-10 40.1 1.3 1.7e-05 24.8 0.1 4.8 4 1 2 6 6 6 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK47368.1 - 2.5e-08 33.3 0.4 0.11 11.5 0.0 5.2 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 PIK47368.1 - 0.00057 19.8 0.1 14 5.7 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 PIK47368.1 - 0.0056 16.0 1.0 4.2 6.6 0.0 4.4 2 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 PIK47368.1 - 0.0095 15.3 0.1 0.076 12.3 0.0 2.4 2 1 0 2 2 2 1 WD40-like domain ATHILA PF03078.15 PIK47368.1 - 0.014 14.2 0.8 0.023 13.5 0.8 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family Utp21 PF04192.12 PIK47368.1 - 0.022 14.3 0.5 0.022 14.3 0.5 1.9 2 1 0 2 2 2 0 Utp21 specific WD40 associated putative domain ATP-synt_C PF00137.21 PIK47369.1 - 1e-35 121.9 34.4 2.9e-22 78.8 13.5 2.0 2 0 0 2 2 2 2 ATP synthase subunit C DUF1035 PF06281.12 PIK47369.1 - 0.034 14.2 1.2 0.08 12.9 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) HSP90 PF00183.18 PIK47370.1 - 3.7e-93 313.2 0.2 8.3e-92 308.7 0.1 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 PIK47370.1 - 1.5e-11 44.3 0.1 3.8e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK47370.1 - 9.1e-10 39.0 0.1 1.9e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AMP-binding PF00501.28 PIK47371.1 - 2.9e-110 368.8 0.0 3.4e-110 368.5 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK47371.1 - 1.1e-17 64.8 0.0 3.6e-17 63.1 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 PIK47371.1 - 0.16 12.3 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK47372.1 - 8.8e-113 377.1 0.0 1e-112 376.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK47372.1 - 1.2e-17 64.6 0.1 3.3e-17 63.2 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 PIK47372.1 - 0.017 15.5 0.2 0.043 14.1 0.1 1.8 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain FA_hydroxylase PF04116.13 PIK47373.1 - 8.9e-22 77.9 16.8 8.9e-22 77.9 16.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily adh_short PF00106.25 PIK47374.1 - 2e-29 102.4 1.5 2.3e-29 102.3 1.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK47374.1 - 6.2e-23 81.6 0.8 1e-22 80.8 0.8 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK47374.1 - 2.4e-08 34.1 0.1 3.4e-08 33.6 0.1 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK47374.1 - 1.5e-06 27.9 0.1 1.6e-06 27.8 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK47374.1 - 4.6e-06 26.0 0.2 1e-05 24.8 0.1 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK47374.1 - 2.3e-05 24.0 0.1 3.9e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 PIK47374.1 - 0.06 12.9 0.1 0.078 12.5 0.1 1.3 1 1 0 1 1 1 0 NmrA-like family adh_short PF00106.25 PIK47375.1 - 3.6e-35 121.2 2.1 4.5e-35 120.9 2.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK47375.1 - 1.4e-28 100.1 1.7 2.4e-28 99.3 1.7 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK47375.1 - 1.1e-08 35.2 0.2 1.7e-08 34.6 0.2 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK47375.1 - 2.5e-05 23.9 0.2 3.1e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK47375.1 - 5e-05 22.6 0.1 9.1e-05 21.7 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK47375.1 - 5.5e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 PIK47375.1 - 0.00061 18.9 0.3 0.00078 18.5 0.3 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 PIK47375.1 - 0.039 14.2 1.1 0.21 11.8 0.2 2.2 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain LppC PF04348.13 PIK47375.1 - 0.069 11.9 0.0 0.069 11.9 0.0 1.1 1 0 0 1 1 1 0 LppC putative lipoprotein Exo_endo_phos PF03372.23 PIK47376.1 - 7.1e-10 38.8 0.0 9.1e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 PIK47378.1 - 5.3e-05 23.1 0.0 7.7e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain adh_short PF00106.25 PIK47379.1 - 1.4e-27 96.4 1.0 9.2e-14 51.3 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK47379.1 - 1.4e-19 70.6 0.2 6e-09 35.8 0.0 2.1 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK47379.1 - 4.6e-07 29.9 0.3 1.5e-06 28.2 0.1 1.8 1 1 1 2 2 2 1 KR domain 3Beta_HSD PF01073.19 PIK47379.1 - 3.6e-05 22.9 0.6 6.6e-05 22.1 0.1 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 PIK47379.1 - 0.00048 19.3 0.1 0.00068 18.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK47379.1 - 0.0005 19.6 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK47379.1 - 0.008 15.6 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase MG3 PF17791.1 PIK47380.1 - 1.2e-12 47.9 0.1 9.6e-12 45.0 0.0 2.2 2 1 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK47380.1 - 1.5e-12 47.5 0.1 5e-12 45.8 0.0 1.9 2 1 0 2 2 2 1 Macroglobulin domain MG4 Integrase_H2C2 PF17921.1 PIK47381.1 - 7.3e-13 48.4 0.2 3.1e-12 46.4 0.2 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK47381.1 - 1.9e-10 41.0 0.0 4e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3896 PF13035.6 PIK47381.1 - 0.041 14.0 0.6 0.24 11.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) zf-H2C2 PF09337.10 PIK47381.1 - 0.12 12.6 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger AphA_like PF14557.6 PIK47381.1 - 0.2 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator ABC_tran PF00005.27 PIK47382.1 - 4.1e-50 169.9 0.0 3.3e-26 92.4 0.0 2.9 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 PIK47382.1 - 1.4e-31 110.2 17.6 2.4e-31 109.4 17.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK47382.1 - 4.2e-11 42.7 1.0 0.027 13.9 0.1 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 PIK47382.1 - 9.5e-07 28.9 0.3 0.11 12.6 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK47382.1 - 3e-06 27.3 0.0 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 PIK47382.1 - 6.9e-05 22.8 0.5 0.36 10.6 0.0 4.2 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 PIK47382.1 - 0.0001 22.8 0.0 0.22 11.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 PIK47382.1 - 0.00012 21.7 0.4 0.4 10.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 PIK47382.1 - 0.00021 21.6 1.1 0.78 10.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 PIK47382.1 - 0.00096 19.7 0.1 1.4 9.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 PIK47382.1 - 0.0088 15.8 1.8 4.2 7.1 0.0 3.2 4 0 0 4 4 4 2 IstB-like ATP binding protein Dynamin_N PF00350.23 PIK47382.1 - 0.012 15.6 2.3 0.71 9.9 0.0 2.9 3 0 0 3 3 3 0 Dynamin family AAA_18 PF13238.6 PIK47382.1 - 0.021 15.3 0.0 3.8 8.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK47382.1 - 0.025 15.0 0.1 8.7 6.8 0.0 3.2 3 0 0 3 3 2 0 RNA helicase AAA_7 PF12775.7 PIK47382.1 - 0.038 13.5 0.1 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 PIK47382.1 - 0.083 13.1 0.6 8.4 6.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 PIK47382.1 - 0.11 12.6 0.5 0.7 9.9 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 PIK47382.1 - 0.11 12.5 0.7 9.3 6.3 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA PF00004.29 PIK47382.1 - 0.19 12.2 1.2 5.5 7.4 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 PIK47382.1 - 0.83 8.8 6.3 12 5.0 0.0 3.1 2 1 0 2 2 2 0 NB-ARC domain TMEM154 PF15102.6 PIK47383.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Comm PF15957.5 PIK47383.1 - 0.08 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Commissureless DUF4006 PF13179.6 PIK47383.1 - 0.085 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF4006) DUF5385 PF17359.2 PIK47383.1 - 0.25 10.9 0.2 0.49 9.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Sigma_reg_N PF13800.6 PIK47383.1 - 0.42 10.9 2.0 1.5 9.1 0.6 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal PA PF02225.22 PIK47384.1 - 5.2e-07 29.6 0.0 8.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 PA domain BRCT PF00533.26 PIK47385.1 - 5.4e-08 33.1 0.1 7.8e-07 29.4 0.0 3.0 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK47385.1 - 1.5e-05 25.3 0.0 0.013 15.9 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK47385.1 - 0.0083 16.0 0.0 0.032 14.1 0.0 2.1 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 PIK47385.1 - 0.027 14.4 0.1 0.086 12.8 0.1 2.0 1 0 0 1 1 1 0 twin BRCT domain CDC45 PF02724.14 PIK47385.1 - 0.73 8.1 25.9 0.02 13.2 16.6 2.3 2 0 0 2 2 2 0 CDC45-like protein Ephrin_rec_like PF07699.13 PIK47386.1 - 5e-07 29.4 9.8 3.9e-06 26.5 4.0 2.3 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK47386.1 - 0.25 11.4 7.7 0.32 11.0 1.1 2.2 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 PIK47386.1 - 1.4 9.4 12.5 0.56 10.7 2.0 3.0 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK47388.1 - 3.6e-06 26.6 3.3 3.6e-06 26.6 3.3 2.3 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 PIK47388.1 - 0.32 11.0 5.2 0.69 9.9 0.4 2.3 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 PIK47388.1 - 3 8.3 9.0 3.3e+02 1.8 9.0 2.6 1 1 0 1 1 1 0 TNFR/NGFR cysteine-rich region PADR1 PF08063.12 PIK47388.1 - 5.1 7.0 8.6 2.9 7.8 0.2 3.1 3 1 1 4 4 4 0 PADR1 (NUC008) domain Ephrin_rec_like PF07699.13 PIK47390.1 - 0.019 14.7 0.5 0.019 14.7 0.5 3.9 4 2 0 4 4 4 0 Putative ephrin-receptor like LRR_8 PF13855.6 PIK47391.1 - 4.5e-22 77.6 20.8 8.2e-11 41.5 3.5 4.4 1 1 3 4 4 4 4 Leucine rich repeat Ephrin_rec_like PF07699.13 PIK47391.1 - 3.1e-06 26.8 3.4 3.1e-06 26.8 3.4 3.4 1 1 2 3 3 3 1 Putative ephrin-receptor like LRR_4 PF12799.7 PIK47391.1 - 9.8e-06 25.8 23.1 0.012 16.0 0.4 5.5 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) DUF326 PF03860.16 PIK47391.1 - 3.2 7.9 6.9 0.73 9.9 2.6 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) TNFR_c6 PF00020.18 PIK47391.1 - 3.7 8.0 12.7 2.7 8.4 0.7 3.8 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region Cthe_2159 PF14262.6 PIK47392.1 - 0.018 14.4 0.5 37 3.5 0.0 3.9 3 1 1 4 4 4 0 Carbohydrate-binding domain-containing protein Cthe_2159 RVT_2 PF07727.14 PIK47393.1 - 9.1e-24 84.4 0.1 1.3e-23 83.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK47394.1 - 1.1e-37 130.0 0.0 1.3e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK47395.1 - 7.1e-06 25.9 1.4 1.6e-05 24.7 0.6 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK47395.1 - 0.03 14.1 0.1 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 Zinc knuckle DUF4399 PF14347.6 PIK47395.1 - 0.034 14.5 0.4 2.3 8.7 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4399) Kazal_2 PF07648.15 PIK47396.1 - 2.5e-22 78.7 40.4 1.5e-11 44.2 6.9 4.0 4 1 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK47396.1 - 7.1e-16 57.9 40.7 1.5e-07 31.3 8.3 4.8 3 2 1 4 4 4 3 Kazal-type serine protease inhibitor domain Ig_3 PF13927.6 PIK47397.1 - 1.4e-22 80.1 2.0 2.7e-07 31.1 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK47397.1 - 2.4e-20 72.4 0.0 3.9e-10 39.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 PIK47397.1 - 7.9e-20 70.8 4.2 1.9e-07 31.1 0.0 4.6 4 1 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK47397.1 - 1.6e-15 57.2 4.3 1.5e-06 28.5 0.8 4.1 3 2 1 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK47397.1 - 5.7e-13 49.0 0.1 1.9e-09 37.7 0.0 3.7 3 1 0 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK47397.1 - 4.3e-08 33.1 4.8 8.7e-07 28.9 0.2 4.1 3 2 0 3 3 2 1 CD80-like C2-set immunoglobulin domain Syndecan PF01034.20 PIK47397.1 - 0.0076 16.2 0.2 0.016 15.1 0.2 1.5 1 0 0 1 1 1 1 Syndecan domain TMEM154 PF15102.6 PIK47397.1 - 0.0078 16.1 4.9 0.018 15.0 4.9 1.6 1 1 0 1 1 1 1 TMEM154 protein family DUF4577 PF15145.6 PIK47397.1 - 0.023 14.8 0.2 0.043 13.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) DUF2207 PF09972.9 PIK47397.1 - 0.098 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Amnionless PF14828.6 PIK47397.1 - 0.14 11.0 0.1 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 Amnionless Ig_3 PF13927.6 PIK47398.1 - 6.6e-11 42.7 0.2 0.00075 20.0 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK47398.1 - 1.3e-09 38.3 1.5 0.00018 21.8 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK47398.1 - 4.8e-06 26.5 0.5 0.021 14.9 0.1 3.0 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK47398.1 - 0.00011 22.3 1.9 0.82 9.9 0.0 3.3 2 1 0 2 2 2 2 Immunoglobulin domain Amnionless PF14828.6 PIK47398.1 - 0.0066 15.3 0.4 0.013 14.4 0.4 1.5 1 0 0 1 1 1 1 Amnionless EphA2_TM PF14575.6 PIK47398.1 - 0.035 15.0 1.5 0.064 14.1 0.2 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 PIK47398.1 - 0.16 11.8 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF4690 PF15756.5 PIK47398.1 - 0.4 11.3 2.9 0.3 11.7 0.3 2.1 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Orf78 PF06024.12 PIK47398.1 - 0.97 9.8 0.0 0.97 9.8 0.0 3.5 3 1 0 3 3 3 0 Orf78 (ac78) Endomucin PF07010.12 PIK47398.1 - 2.6 8.0 10.3 0.54 10.2 0.2 2.7 1 1 0 2 2 2 0 Endomucin Syndecan PF01034.20 PIK47398.1 - 3.9 7.5 5.5 11 6.1 5.5 1.7 1 0 0 1 1 1 0 Syndecan domain DUF4440 PF14534.6 PIK47399.1 - 1.6e-08 34.9 0.0 1.9e-08 34.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 PIK47399.1 - 0.0003 21.4 0.0 0.00042 20.9 0.0 1.3 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 PIK47399.1 - 0.047 14.0 0.0 0.051 13.8 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain ADH_N PF08240.12 PIK47400.1 - 6.2e-31 106.5 1.0 1.7e-30 105.1 1.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK47400.1 - 1.5e-23 83.2 0.1 2.2e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK47400.1 - 3.3e-11 43.1 0.4 2.1e-10 40.5 0.4 2.0 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK47400.1 - 7.4e-05 22.1 0.7 0.00011 21.6 0.7 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 PIK47400.1 - 0.00068 20.7 0.0 0.0011 20.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 PIK47400.1 - 0.028 13.6 0.1 0.042 13.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RBP_receptor PF14752.6 PIK47401.1 - 5.2e-124 415.1 20.4 6e-124 414.9 20.4 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor SNF2_N PF00176.23 PIK47402.1 - 8.9e-65 218.7 0.7 2e-64 217.5 0.7 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDH1_2_SANT_HL1 PF18375.1 PIK47402.1 - 3.4e-34 117.4 4.8 2.3e-33 114.7 0.0 4.4 3 0 0 3 3 3 1 CDH1/2 SANT-Helical linker 1 Chromo PF00385.24 PIK47402.1 - 7.5e-29 99.4 10.9 3.5e-19 68.4 0.1 4.5 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 PIK47402.1 - 1.3e-21 77.0 0.0 2.9e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK47402.1 - 3.4e-09 37.0 0.0 3.9e-07 30.2 0.0 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 PIK47402.1 - 1.1e-06 28.1 0.5 1.1e-06 28.1 0.5 2.2 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SLIDE PF09111.10 PIK47403.1 - 2.5e-05 24.3 0.1 0.00011 22.1 0.1 2.0 1 1 0 1 1 1 1 SLIDE Myb_DNA-binding PF00249.31 PIK47403.1 - 0.0092 16.2 0.1 0.026 14.7 0.1 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain TssC PF17541.2 PIK47403.1 - 0.084 11.7 0.2 0.11 11.4 0.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB DUF4208 PF13907.6 PIK47404.1 - 1.8e-26 92.4 0.4 2.8e-26 91.8 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) DUF615 PF04751.14 PIK47404.1 - 0.077 13.0 0.9 0.16 12.0 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF615) UvrD-helicase PF00580.21 PIK47405.1 - 0.012 15.2 0.0 0.012 15.2 0.0 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 PIK47405.1 - 0.11 12.2 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain MSL2-CXC PF16682.5 PIK47405.1 - 0.14 12.3 0.8 0.34 11.1 0.8 1.6 1 0 0 1 1 1 0 CXC domain of E3 ubiquitin-protein ligase MSL2 ADAM_spacer1 PF05986.14 PIK47406.1 - 6.7e-21 74.5 0.1 1.2e-20 73.6 0.1 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 NTR PF01759.21 PIK47406.1 - 1.8e-10 40.5 0.1 1.8e-10 40.5 0.1 2.0 2 0 0 2 2 2 1 UNC-6/NTR/C345C module RR_TM4-6 PF06459.12 PIK47406.1 - 0.017 14.9 4.6 0.024 14.5 4.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCDC106 PF15794.5 PIK47406.1 - 0.044 13.5 7.5 0.077 12.7 7.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 YqfQ PF14181.6 PIK47406.1 - 0.064 13.4 9.4 0.11 12.8 9.4 1.3 1 0 0 1 1 1 0 YqfQ-like protein RNA_pol_Rpc4 PF05132.14 PIK47406.1 - 0.97 9.9 8.3 1.7 9.1 8.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF3464 PF11947.8 PIK47406.1 - 7.3 6.3 6.3 13 5.5 6.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PPTA PF01239.22 PIK47407.1 - 2.3e-07 30.3 16.8 0.00082 19.0 0.3 4.4 5 0 0 5 5 5 3 Protein prenyltransferase alpha subunit repeat Bcl-2 PF00452.19 PIK47408.1 - 5.6e-26 91.1 0.0 1e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Bclx_interact PF08945.10 PIK47408.1 - 0.14 12.0 0.0 0.42 10.4 0.0 1.8 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain T6PP_N PF18572.1 PIK47408.1 - 0.15 12.0 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Filamin PF00630.19 PIK47409.1 - 1.6e-100 330.8 19.9 1.2e-19 71.1 0.1 6.1 6 0 0 6 6 6 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 PIK47409.1 - 1.4e-14 54.1 10.8 7.3e-05 23.0 0.3 6.6 5 2 0 6 6 6 3 Invasin, domain 3 Big_3_5 PF16640.5 PIK47409.1 - 1.5e-13 50.7 15.0 0.0029 17.8 1.1 6.4 6 0 0 6 6 6 3 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 PIK47409.1 - 8.3e-08 32.1 3.3 0.044 13.7 0.0 5.1 6 1 0 6 6 6 2 Y_Y_Y domain YtkA PF13115.6 PIK47409.1 - 3.6e-06 27.5 12.1 0.056 14.1 1.5 6.4 5 1 0 6 6 6 1 YtkA-like DUF5060 PF16586.5 PIK47409.1 - 0.00057 20.2 0.2 1.6 9.2 0.0 5.1 6 0 0 6 6 6 1 Domain of unknown function (DUF5060) PKD PF00801.20 PIK47409.1 - 0.005 16.7 0.9 24 4.9 0.1 4.8 5 0 0 5 5 5 0 PKD domain MG2 PF01835.19 PIK47409.1 - 0.035 14.6 0.1 4.7 7.7 0.0 3.4 3 0 0 3 3 3 0 MG2 domain Big_1 PF02369.16 PIK47409.1 - 0.064 13.3 5.0 33 4.6 0.0 5.1 5 1 0 5 5 5 0 Bacterial Ig-like domain (group 1) Inhibitor_I42 PF09394.10 PIK47409.1 - 0.14 12.5 2.9 13 6.3 0.1 4.7 5 1 1 6 6 6 0 Chagasin family peptidase inhibitor I42 PEGA PF08308.11 PIK47409.1 - 0.78 9.7 13.1 1.3e+02 2.6 0.0 6.4 5 2 0 5 5 5 0 PEGA domain Filamin PF00630.19 PIK47410.1 - 3.5e-79 262.3 3.3 1.8e-17 64.0 0.0 5.1 5 0 0 5 5 5 5 Filamin/ABP280 repeat Y_Y_Y PF07495.13 PIK47410.1 - 4.2e-10 39.4 3.6 0.13 12.3 0.1 4.3 4 0 0 4 4 4 3 Y_Y_Y domain YtkA PF13115.6 PIK47410.1 - 1.9e-06 28.4 0.0 0.058 14.0 0.0 4.3 4 0 0 4 4 4 1 YtkA-like Big_1 PF02369.16 PIK47410.1 - 1e-05 25.4 0.0 0.95 9.5 0.0 4.6 4 1 0 4 4 4 2 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 PIK47410.1 - 2.1e-05 24.7 2.2 0.23 11.8 0.1 4.7 4 2 0 4 4 4 1 Invasin, domain 3 CarboxypepD_reg PF13620.6 PIK47410.1 - 3.3e-05 24.1 1.8 2.1 8.7 0.0 3.8 3 0 0 3 3 3 2 Carboxypeptidase regulatory-like domain Big_3_5 PF16640.5 PIK47410.1 - 0.00098 19.3 10.7 1.5 9.1 1.3 4.2 5 0 0 5 5 4 2 Bacterial Ig-like domain (group 3) DUF5060 PF16586.5 PIK47410.1 - 0.0018 18.6 0.0 18 5.8 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF5060) PPC PF04151.15 PIK47410.1 - 0.0057 17.7 4.6 13 7.0 0.1 4.5 4 1 0 4 4 4 1 Bacterial pre-peptidase C-terminal domain fn3_3 PF14686.6 PIK47410.1 - 0.13 12.1 0.4 0.39 10.5 0.1 2.0 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain II SH2 PF00017.24 PIK47410.1 - 0.2 11.8 0.0 6.6 6.9 0.0 2.4 2 0 0 2 2 2 0 SH2 domain PapC_N PF13954.6 PIK47410.1 - 0.24 11.4 0.7 12 5.9 0.0 3.5 4 0 0 4 4 4 0 PapC N-terminal domain PKD PF00801.20 PIK47410.1 - 2.6 7.9 6.2 45 4.0 0.0 4.6 6 0 0 6 6 5 0 PKD domain MutS_V PF00488.21 PIK47411.1 - 8.4e-69 231.4 0.9 1.4e-68 230.7 0.1 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 PIK47411.1 - 1e-31 110.7 1.5 1e-31 110.7 1.5 1.7 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 PIK47411.1 - 1.7e-12 47.5 0.0 8.7e-12 45.2 0.0 2.3 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 PIK47411.1 - 3.3e-11 43.6 3.0 6.6e-11 42.6 0.0 2.9 4 0 0 4 4 4 1 MutS domain II AAA_14 PF13173.6 PIK47411.1 - 0.023 14.7 0.0 0.18 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK47411.1 - 0.06 13.6 0.0 0.24 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK47411.1 - 0.068 13.1 0.6 5.9 6.7 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 PIK47411.1 - 0.072 12.9 0.1 3.7 7.4 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 PIK47411.1 - 0.22 12.0 1.2 6.5 7.2 0.1 2.7 2 0 0 2 2 2 0 AAA domain RhoGAP PF00620.27 PIK47412.1 - 2.4e-18 66.4 0.0 3.4e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 PIK47412.1 - 6.1e-06 25.7 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK47412.1 - 0.0028 17.3 0.0 0.0052 16.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK47412.1 - 0.027 14.3 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain DUF1298 PF06974.13 PIK47413.1 - 0.1 12.6 1.6 0.17 11.8 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1298) XisH PF08814.10 PIK47413.1 - 0.11 12.6 0.2 0.42 10.8 0.0 1.8 2 0 0 2 2 2 0 XisH protein CorA PF01544.18 PIK47413.1 - 2 7.7 5.9 4.3 6.6 5.9 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein FAM72 PF14976.6 PIK47414.1 - 5.5e-23 81.7 1.5 5.6e-23 81.7 1.5 1.0 1 0 0 1 1 1 1 FAM72 protein Exostosin PF03016.15 PIK47415.1 - 0.018 14.3 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 Exostosin family ATP-synt PF00231.19 PIK47416.1 - 1.6e-62 211.8 0.1 1.9e-62 211.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase Glyco_transf_29 PF00777.18 PIK47417.1 - 4.3e-49 167.3 0.6 5.1e-49 167.1 0.6 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Rhodanese PF00581.20 PIK47419.1 - 5.1e-10 39.8 0.0 8.6e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Bromo_TP PF07524.13 PIK47420.1 - 9.1e-14 51.2 0.0 2.2e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 PIK47420.1 - 0.034 14.3 0.0 0.092 12.9 0.0 1.7 1 0 0 1 1 1 0 Histone-fold protein TFIID-31kDa PF02291.15 PIK47420.1 - 0.071 13.2 0.2 0.44 10.6 0.0 2.2 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit WGG PF10273.9 PIK47421.1 - 5.2e-27 94.3 0.1 1.2e-26 93.2 0.1 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 ThiF PF00899.21 PIK47422.1 - 2e-62 210.7 0.0 3.7e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 PIK47422.1 - 7.8e-23 80.4 0.4 1.1e-22 79.9 0.4 1.2 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 PIK47422.1 - 2.4e-05 24.8 0.1 5.4e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.20 PIK47422.1 - 0.0066 16.5 0.0 0.019 15.0 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FeoA PF04023.14 PIK47422.1 - 0.013 15.7 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 FeoA domain PRA1 PF03208.19 PIK47423.1 - 3.6e-27 94.7 2.8 4.4e-27 94.5 2.8 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF3784 PF12650.7 PIK47423.1 - 0.00084 19.5 4.2 0.0011 19.1 1.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3784) ABC2_membrane_5 PF13346.6 PIK47423.1 - 0.006 16.2 4.2 0.0078 15.8 4.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein TrbC PF04956.13 PIK47423.1 - 0.014 15.6 0.2 0.19 12.0 0.3 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF4131 PF13567.6 PIK47423.1 - 0.26 10.9 4.9 0.092 12.4 1.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Pam17 PF08566.10 PIK47423.1 - 0.28 11.0 1.3 1.8 8.4 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 DUF2681 PF10883.8 PIK47423.1 - 0.29 11.6 0.9 0.52 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ABC_membrane PF00664.23 PIK47423.1 - 1.6 8.3 7.5 0.12 12.0 1.8 1.8 1 1 0 2 2 2 0 ABC transporter transmembrane region DUF3302 PF11742.8 PIK47423.1 - 2.1 8.6 6.8 0.15 12.2 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3302) SdpI PF13630.6 PIK47423.1 - 2.5 8.3 6.0 4.6 7.4 2.4 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family Pkinase PF00069.25 PIK47424.1 - 3.7e-48 164.2 0.4 2.3e-34 119.0 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47424.1 - 1.3e-26 93.5 0.0 6.6e-15 55.1 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK47424.1 - 0.00035 20.0 0.0 0.00063 19.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK47424.1 - 0.0068 15.4 0.1 0.022 13.7 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Emaravirus_P4 PF16505.5 PIK47425.1 - 0.074 12.1 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily DUF4490 PF14892.6 PIK47426.1 - 5.8e-33 113.0 2.9 7.2e-33 112.7 2.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) RNA_capsid PF03035.14 PIK47426.1 - 0.056 13.5 2.3 0.076 13.0 1.6 1.5 1 1 1 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein Pr_beta_C PF12465.8 PIK47426.1 - 0.082 12.3 0.2 0.17 11.3 0.2 1.6 1 1 0 1 1 1 0 Proteasome beta subunits C terminal RabGAP-TBC PF00566.18 PIK47427.1 - 5.9e-41 140.5 4.0 2.3e-40 138.6 1.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TP2 PF01254.18 PIK47427.1 - 0.66 10.6 11.5 0.69 10.5 10.3 1.6 1 1 0 1 1 1 0 Nuclear transition protein 2 F-actin_cap_A PF01267.17 PIK47428.1 - 3.5e-97 325.0 0.2 3.9e-97 324.8 0.2 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF520 PF04461.13 PIK47428.1 - 0.014 15.5 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF520) DSPc PF00782.20 PIK47430.1 - 1.5e-12 47.5 0.1 3.7e-12 46.2 0.0 1.7 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK47430.1 - 8.2e-06 25.5 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK47430.1 - 0.00017 21.6 1.1 0.00039 20.5 0.1 2.0 2 1 0 2 2 2 1 Tyrosine phosphatase family CDKN3 PF05706.12 PIK47430.1 - 0.00085 19.0 0.0 0.0019 17.9 0.0 1.5 1 1 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPn PF14671.6 PIK47430.1 - 0.039 14.4 0.3 0.095 13.1 0.0 1.7 2 0 0 2 2 2 0 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 PIK47430.1 - 0.064 13.4 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF2151 PF10221.9 PIK47431.1 - 7.5e-134 447.9 0.0 7.4e-70 236.4 0.0 2.0 1 1 1 2 2 2 2 Cell cycle and development regulator DUF3220 PF11516.8 PIK47431.1 - 0.15 12.3 0.0 0.56 10.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) WhiA_N PF10298.9 PIK47431.1 - 0.18 11.9 0.1 2.6 8.1 0.2 2.3 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain Hist_deacetyl PF00850.19 PIK47432.1 - 1.7e-69 234.6 0.0 2.8e-69 233.9 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain zf-UBP PF02148.19 PIK47432.1 - 3.6e-17 62.4 10.8 3.6e-17 62.4 10.8 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 PIK47432.1 - 0.0002 21.1 0.2 0.00091 18.9 0.4 2.0 2 0 0 2 2 2 1 Variant UBP zinc finger FERM_M PF00373.18 PIK47433.1 - 1.9e-09 38.0 0.1 4.1e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 FERM central domain Metallophos PF00149.28 PIK47434.1 - 8.7e-24 85.2 2.4 1.2e-23 84.7 2.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK47434.1 - 1.1e-13 51.3 3.0 2e-13 50.5 3.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain LytTR PF04397.15 PIK47435.1 - 0.21 11.8 1.0 10 6.4 0.0 2.9 3 0 0 3 3 3 0 LytTr DNA-binding domain Acetyltransf_1 PF00583.25 PIK47436.1 - 4.6e-12 46.2 0.0 8.4e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK47436.1 - 1.5e-07 31.4 0.0 8.3e-07 29.0 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK47436.1 - 8.2e-06 26.2 0.0 1.4e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK47436.1 - 0.00016 21.5 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 PIK47436.1 - 0.0019 17.7 1.2 0.003 17.1 1.2 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 PIK47436.1 - 0.0071 16.4 0.0 0.068 13.2 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 PIK47436.1 - 0.042 13.5 0.0 0.072 12.8 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 PIK47436.1 - 0.051 14.2 0.0 0.14 12.9 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase_Tyr PF07714.17 PIK47437.1 - 2.6e-51 174.4 0.1 4.6e-51 173.6 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47437.1 - 5.4e-28 98.1 0.1 9.5e-28 97.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK47437.1 - 1.8e-16 60.0 0.1 7e-16 58.1 0.0 2.0 2 0 0 2 2 2 1 SH2 domain UPF0193 PF05250.11 PIK47438.1 - 1.6e-73 247.1 6.9 1.8e-73 247.0 6.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) DUF3585 PF12130.8 PIK47439.1 - 1.9e-36 125.2 29.2 2.3e-36 124.9 29.2 1.1 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain Thg1C PF14413.6 PIK47439.1 - 0.14 12.3 5.3 0.27 11.4 5.3 1.6 1 1 0 1 1 1 0 Thg1 C terminal domain DUF4936 PF16290.5 PIK47439.1 - 0.18 12.5 2.6 0.24 12.1 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4936) CH PF00307.31 PIK47440.1 - 1.1e-06 28.7 0.0 1.5e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain Nudc_N PF14050.6 PIK47441.1 - 5.7e-21 74.3 0.2 1e-20 73.4 0.2 1.4 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 PIK47441.1 - 4e-14 53.4 0.5 9.2e-14 52.2 0.5 1.6 1 0 0 1 1 1 1 CS domain Pyr_redox_3 PF13738.6 PIK47442.1 - 1.9e-14 53.7 0.0 1.6e-12 47.3 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 PIK47442.1 - 0.26 9.7 0.0 0.57 8.5 0.0 1.5 1 1 1 2 2 2 0 Flavin-binding monooxygenase-like EGF PF00008.27 PIK47443.1 - 2.2e-57 190.9 103.1 2.4e-10 40.5 5.9 8.4 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK47443.1 - 5e-34 115.8 100.6 1.2e-07 32.1 8.7 9.8 9 1 1 10 10 10 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK47443.1 - 8.6e-24 83.5 113.9 3e-07 30.5 9.9 8.2 6 2 2 8 8 8 8 Calcium-binding EGF domain EGF_2 PF07974.13 PIK47443.1 - 5.1e-21 74.7 123.9 0.00019 21.7 10.6 8.3 8 0 0 8 8 8 6 EGF-like domain cEGF PF12662.7 PIK47443.1 - 1.7e-06 27.8 6.9 4.1e-05 23.4 1.2 8.7 8 2 0 8 8 8 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK47443.1 - 1.2e-05 25.5 90.2 0.46 10.8 7.0 8.6 2 2 6 8 8 8 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK47443.1 - 6.8e-05 23.0 89.6 0.056 13.7 7.0 8.9 5 3 3 8 8 8 6 EGF domain EGF PF00008.27 PIK47444.1 - 2e-30 104.7 73.4 5.8e-08 32.9 6.7 6.5 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK47444.1 - 9.2e-19 67.3 72.0 1.4e-07 31.8 4.2 7.6 6 1 1 7 7 7 6 Human growth factor-like EGF EGF_2 PF07974.13 PIK47444.1 - 1.8e-08 34.6 91.6 0.00064 20.0 9.7 6.3 6 0 0 6 6 6 6 EGF-like domain FXa_inhibition PF14670.6 PIK47444.1 - 0.0087 16.3 70.3 1 9.7 8.7 6.5 3 2 3 6 6 6 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK47444.1 - 0.058 13.3 0.4 0.058 13.3 0.4 7.3 6 1 0 6 6 6 0 Complement Clr-like EGF-like EGF PF00008.27 PIK47445.1 - 3.7e-23 81.5 54.6 3.5e-06 27.2 2.7 5.5 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.7 PIK47445.1 - 1e-17 64.0 48.2 6.2e-06 26.6 4.9 6.2 5 0 0 5 5 5 5 Human growth factor-like EGF EGF_CA PF07645.15 PIK47445.1 - 2.4e-10 40.5 61.2 5.2e-07 29.8 8.9 5.5 2 2 2 5 5 5 5 Calcium-binding EGF domain EGF_2 PF07974.13 PIK47445.1 - 9.8e-08 32.2 67.3 0.00024 21.4 8.2 5.4 5 0 0 5 5 5 4 EGF-like domain EGF_3 PF12947.7 PIK47445.1 - 0.022 15.0 5.2 0.022 15.0 5.2 5.6 5 0 0 5 5 5 0 EGF domain MAP17 PF15807.5 PIK47445.1 - 0.18 12.1 0.0 0.26 11.5 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Laminin_EGF PF00053.24 PIK47445.1 - 0.52 10.5 50.8 3.5 7.8 6.1 5.4 1 1 4 5 5 5 0 Laminin EGF domain FXa_inhibition PF14670.6 PIK47445.1 - 0.68 10.3 56.6 0.14 12.5 5.3 5.8 5 1 1 6 6 6 0 Coagulation Factor Xa inhibitory site Ank_2 PF12796.7 PIK47446.1 - 8.3e-29 100.0 11.2 3.6e-10 40.3 0.2 4.8 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK47446.1 - 4.1e-28 97.1 10.9 4.8e-12 45.9 0.1 7.6 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK47446.1 - 1.5e-25 89.2 7.8 4.3e-05 24.0 0.0 6.3 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK47446.1 - 4.3e-21 72.7 7.8 6.7e-05 23.0 0.1 8.7 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 PIK47446.1 - 2.7e-18 65.5 14.7 0.0001 22.6 0.1 8.0 7 1 1 8 8 8 5 Ankyrin repeat Patatin PF01734.22 PIK47446.1 - 7.1e-18 65.5 0.3 2.7e-17 63.6 0.3 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3967 PF13152.6 PIK47447.1 - 0.11 12.3 0.1 0.11 12.3 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3967) Cast PF10174.9 PIK47448.1 - 3e-05 22.5 4.7 3.1e-05 22.5 4.7 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone TMPIT PF07851.13 PIK47448.1 - 8.5e-05 22.0 2.6 0.00012 21.4 2.6 1.2 1 0 0 1 1 1 1 TMPIT-like protein HOOK PF05622.12 PIK47448.1 - 0.00058 18.2 10.0 0.00072 17.8 10.0 1.1 1 0 0 1 1 1 1 HOOK protein ATG16 PF08614.11 PIK47448.1 - 0.00061 20.1 3.3 0.00061 20.1 3.3 1.9 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) IFT57 PF10498.9 PIK47448.1 - 0.00094 18.2 11.3 0.0014 17.7 11.3 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 TMF_TATA_bd PF12325.8 PIK47448.1 - 0.0015 18.8 9.6 0.011 16.0 9.4 2.0 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding SKA1 PF07160.12 PIK47448.1 - 0.0015 18.4 6.4 0.0016 18.4 6.4 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 ZapB PF06005.12 PIK47448.1 - 0.0018 18.6 1.3 0.0018 18.6 1.3 2.1 1 1 1 2 2 2 1 Cell division protein ZapB Filament PF00038.21 PIK47448.1 - 0.0019 17.8 3.4 0.0024 17.5 3.4 1.2 1 0 0 1 1 1 1 Intermediate filament protein EzrA PF06160.12 PIK47448.1 - 0.0027 15.9 4.6 0.004 15.4 4.6 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA FPP PF05911.11 PIK47448.1 - 0.0028 16.0 8.6 0.0035 15.6 8.6 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil MAD PF05557.13 PIK47448.1 - 0.0028 16.1 6.1 0.0034 15.8 6.1 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein LPP PF04728.13 PIK47448.1 - 0.0032 17.8 5.1 3.7 8.0 2.4 3.4 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Fez1 PF06818.15 PIK47448.1 - 0.0033 17.9 7.6 0.0051 17.3 7.6 1.2 1 0 0 1 1 1 1 Fez1 ABC_tran_CTD PF16326.5 PIK47448.1 - 0.0035 17.6 7.1 0.0043 17.3 3.1 2.6 2 1 0 2 2 1 1 ABC transporter C-terminal domain CENP-F_leu_zip PF10473.9 PIK47448.1 - 0.0037 17.3 12.2 0.0068 16.4 12.2 1.4 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SHE3 PF17078.5 PIK47448.1 - 0.004 16.9 5.6 0.0058 16.4 5.6 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 ERM PF00769.19 PIK47448.1 - 0.004 17.0 3.9 0.0043 16.9 3.9 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family FAM184 PF15665.5 PIK47448.1 - 0.004 17.0 6.2 0.0061 16.4 6.2 1.2 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B Spc7 PF08317.11 PIK47448.1 - 0.0041 16.0 7.3 0.0041 16.0 7.3 1.5 1 1 1 2 2 2 2 Spc7 kinetochore protein Sec3_C PF09763.9 PIK47448.1 - 0.0048 15.4 6.6 0.0056 15.1 6.6 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 ZYG-11_interact PF05884.12 PIK47448.1 - 0.0048 16.3 2.9 0.0073 15.8 2.9 1.2 1 0 0 1 1 1 1 Interactor of ZYG-11 AAA_13 PF13166.6 PIK47448.1 - 0.0049 15.6 4.0 0.0052 15.5 4.0 1.1 1 0 0 1 1 1 1 AAA domain Laminin_II PF06009.12 PIK47448.1 - 0.0052 16.8 5.5 0.0097 15.9 5.5 1.5 1 0 0 1 1 1 1 Laminin Domain II DUF812 PF05667.11 PIK47448.1 - 0.0069 15.3 11.8 0.0092 14.9 11.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Nup88 PF10168.9 PIK47448.1 - 0.007 14.2 1.8 0.0071 14.2 1.8 1.1 1 0 0 1 1 1 1 Nuclear pore component CREPT PF16566.5 PIK47448.1 - 0.0073 16.5 6.3 0.055 13.6 6.3 2.2 1 1 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour HemX PF04375.14 PIK47448.1 - 0.0089 15.4 7.5 0.011 15.0 7.5 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Baculo_PEP_C PF04513.12 PIK47448.1 - 0.0091 16.0 4.7 0.029 14.4 4.7 1.8 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.9 PIK47448.1 - 0.0093 16.2 9.7 0.075 13.3 6.4 2.3 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec34 PF04136.15 PIK47448.1 - 0.0099 15.8 5.3 0.02 14.8 5.3 1.6 1 1 0 1 1 1 1 Sec34-like family FlaC_arch PF05377.11 PIK47448.1 - 0.01 16.2 12.3 0.28 11.6 0.2 3.4 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 PIK47448.1 - 0.011 15.1 1.0 0.012 15.0 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 PIK47448.1 - 0.013 14.1 3.3 0.014 14.0 3.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Laminin_I PF06008.14 PIK47448.1 - 0.014 15.2 7.7 0.024 14.4 7.7 1.4 1 0 0 1 1 1 0 Laminin Domain I NPV_P10 PF05531.12 PIK47448.1 - 0.014 15.8 6.4 0.64 10.5 0.7 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein PIN_8 PF18476.1 PIK47448.1 - 0.016 15.1 2.0 0.019 14.8 2.0 1.1 1 0 0 1 1 1 0 PIN like domain RmuC PF02646.16 PIK47448.1 - 0.02 14.1 5.7 0.022 13.9 4.7 1.7 1 1 0 1 1 1 0 RmuC family Seryl_tRNA_N PF02403.22 PIK47448.1 - 0.02 15.1 10.2 0.039 14.2 0.9 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 PIK47448.1 - 0.02 14.9 8.8 0.1 12.6 6.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Leu_zip PF15294.6 PIK47448.1 - 0.021 14.4 9.6 0.03 13.9 9.6 1.2 1 0 0 1 1 1 0 Leucine zipper Mer2 PF09074.10 PIK47448.1 - 0.022 14.6 10.7 0.036 13.9 10.7 1.3 1 0 0 1 1 1 0 Mer2 DUF1759 PF03564.15 PIK47448.1 - 0.023 14.6 1.9 0.023 14.6 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) APG6_N PF17675.1 PIK47448.1 - 0.025 15.1 6.6 0.046 14.2 6.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 PIK47448.1 - 0.026 15.3 6.4 0.027 15.2 3.9 2.0 1 1 1 2 2 2 0 Occludin homology domain CK2S PF15011.6 PIK47448.1 - 0.029 14.3 5.0 0.11 12.4 5.0 2.0 1 1 0 1 1 1 0 Casein Kinase 2 substrate DHR10 PF18595.1 PIK47448.1 - 0.029 14.4 8.7 0.14 12.2 8.8 2.0 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain BST2 PF16716.5 PIK47448.1 - 0.03 14.9 11.4 0.44 11.2 3.4 2.2 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 COG2 PF06148.11 PIK47448.1 - 0.035 14.2 7.3 0.066 13.3 7.3 1.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Peptidase_C65 PF10275.9 PIK47448.1 - 0.038 13.4 2.4 0.058 12.8 2.4 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain HAUS-augmin3 PF14932.6 PIK47448.1 - 0.039 13.5 7.0 0.057 13.0 7.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2730 PF10805.8 PIK47448.1 - 0.043 13.9 8.4 0.25 11.4 2.6 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF2730) TolA_bind_tri PF16331.5 PIK47448.1 - 0.045 13.8 13.7 0.27 11.4 2.2 3.0 1 1 2 3 3 3 0 TolA binding protein trimerisation FliD_N PF02465.18 PIK47448.1 - 0.046 14.4 8.7 14 6.4 8.7 2.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Swi5 PF07061.11 PIK47448.1 - 0.046 13.8 3.7 0.32 11.1 3.7 2.2 1 1 0 1 1 1 0 Swi5 TACC_C PF05010.14 PIK47448.1 - 0.052 13.3 9.8 0.12 12.2 9.8 1.5 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Tho2 PF11262.8 PIK47448.1 - 0.053 12.7 7.0 0.074 12.2 7.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 XhlA PF10779.9 PIK47448.1 - 0.056 13.7 0.7 0.056 13.7 0.7 3.0 1 1 2 3 3 3 0 Haemolysin XhlA Phage_GPO PF05929.11 PIK47448.1 - 0.057 13.0 5.0 0.085 12.5 5.0 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HMMR_N PF15905.5 PIK47448.1 - 0.058 12.9 9.0 0.081 12.4 9.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Nsp1_C PF05064.13 PIK47448.1 - 0.06 13.2 6.3 0.1 12.4 6.3 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region Golgin_A5 PF09787.9 PIK47448.1 - 0.064 12.7 8.1 0.11 12.0 8.1 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 OmpH PF03938.14 PIK47448.1 - 0.069 13.5 10.1 0.17 12.2 10.1 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Bap31_Bap29_C PF18035.1 PIK47448.1 - 0.073 13.1 2.1 0.41 10.7 2.1 2.3 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain AATF-Che1 PF13339.6 PIK47448.1 - 0.078 13.7 6.1 0.15 12.7 6.1 1.5 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Tropomyosin_1 PF12718.7 PIK47448.1 - 0.082 13.1 6.9 0.14 12.3 6.9 1.4 1 0 0 1 1 1 0 Tropomyosin like GAS PF13851.6 PIK47448.1 - 0.083 12.2 12.4 0.34 10.2 12.5 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 PIK47448.1 - 0.087 12.8 11.2 0.14 12.1 6.8 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Exonuc_VII_L PF02601.15 PIK47448.1 - 0.094 12.3 4.8 0.12 11.9 4.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PI3K_P85_iSH2 PF16454.5 PIK47448.1 - 0.1 12.2 10.7 0.16 11.5 10.7 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ATP-synt_D PF01813.17 PIK47448.1 - 0.11 12.4 5.7 0.14 12.0 5.2 1.5 1 1 0 1 1 1 0 ATP synthase subunit D KASH_CCD PF14662.6 PIK47448.1 - 0.13 12.1 10.8 0.61 9.9 10.8 2.0 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CASP_C PF08172.12 PIK47448.1 - 0.14 11.5 5.1 0.1 11.9 3.0 1.7 1 1 0 1 1 1 0 CASP C terminal Cluap1 PF10234.9 PIK47448.1 - 0.14 11.5 6.8 0.22 10.9 6.8 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 TPR_MLP1_2 PF07926.12 PIK47448.1 - 0.14 12.2 8.6 0.08 13.0 4.8 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Syntaxin_2 PF14523.6 PIK47448.1 - 0.14 12.5 10.0 0.51 10.7 7.9 2.2 1 1 1 2 2 2 0 Syntaxin-like protein Csm1_N PF18504.1 PIK47448.1 - 0.15 12.4 8.6 0.13 12.6 1.5 3.1 1 1 2 3 3 3 0 Csm1 N-terminal domain LXG PF04740.12 PIK47448.1 - 0.16 11.7 11.2 0.56 9.9 10.6 2.1 1 1 0 1 1 1 0 LXG domain of WXG superfamily Spectrin PF00435.21 PIK47448.1 - 0.16 12.5 6.9 0.57 10.7 6.9 1.9 1 1 0 1 1 1 0 Spectrin repeat YabA PF06156.13 PIK47448.1 - 0.16 12.6 10.0 0.52 11.0 10.0 2.0 1 1 0 1 1 1 0 Initiation control protein YabA Het-C PF07217.11 PIK47448.1 - 0.16 10.4 4.9 0.19 10.2 4.9 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF948 PF06103.11 PIK47448.1 - 0.18 12.1 6.9 1.7 8.9 5.3 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Lebercilin PF15619.6 PIK47448.1 - 0.18 11.5 11.1 1.4e+02 2.0 0.2 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease SlyX PF04102.12 PIK47448.1 - 0.18 12.4 6.4 0.9 10.2 3.5 2.8 1 1 1 2 2 2 0 SlyX Prefoldin PF02996.17 PIK47448.1 - 0.19 11.7 9.7 0.088 12.7 1.2 2.5 2 1 1 3 3 2 0 Prefoldin subunit Sec8_exocyst PF04048.14 PIK47448.1 - 0.2 11.5 5.9 0.4 10.6 4.9 1.7 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Fib_alpha PF08702.10 PIK47448.1 - 0.21 11.7 12.1 0.81 9.9 12.1 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family STAT_alpha PF01017.20 PIK47448.1 - 0.22 11.4 12.1 0.97 9.3 12.2 1.8 1 1 1 2 2 2 0 STAT protein, all-alpha domain PRKG1_interact PF15898.5 PIK47448.1 - 0.23 12.4 8.6 0.24 12.3 7.3 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain BRE1 PF08647.11 PIK47448.1 - 0.24 11.5 14.6 0.04 14.0 8.9 2.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase LemA PF04011.12 PIK47448.1 - 0.24 11.3 5.7 0.45 10.3 5.7 1.4 1 0 0 1 1 1 0 LemA family DUF3450 PF11932.8 PIK47448.1 - 0.25 10.6 9.6 0.77 9.0 9.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 PIK47448.1 - 0.25 11.4 10.5 0.35 11.0 10.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SOAR PF16533.5 PIK47448.1 - 0.26 11.3 4.3 0.33 10.9 3.5 1.6 1 1 0 1 1 1 0 STIM1 Orai1-activating region TEX13 PF15186.6 PIK47448.1 - 0.27 10.9 6.3 1.4 8.6 3.2 2.5 2 1 1 3 3 3 0 Testis-expressed sequence 13 protein family DUF2203 PF09969.9 PIK47448.1 - 0.29 11.9 2.5 0.71 10.6 2.2 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DASH_Duo1 PF08651.10 PIK47448.1 - 0.31 10.8 5.1 5.5 6.9 0.1 2.5 1 1 1 2 2 2 0 DASH complex subunit Duo1 Phage_GP20 PF06810.11 PIK47448.1 - 0.32 10.8 9.8 0.22 11.3 8.3 1.5 1 1 0 1 1 1 0 Phage minor structural protein GP20 COG5 PF10392.9 PIK47448.1 - 0.33 11.1 4.4 1.6 8.9 0.3 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 THOC7 PF05615.13 PIK47448.1 - 0.33 11.2 6.2 0.7 10.2 6.1 1.6 1 1 0 1 1 1 0 Tho complex subunit 7 FliJ PF02050.16 PIK47448.1 - 0.33 11.2 9.2 0.26 11.5 4.7 2.0 1 1 0 1 1 1 0 Flagellar FliJ protein DUF641 PF04859.12 PIK47448.1 - 0.35 11.2 5.4 0.39 11.1 2.8 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) WXG100 PF06013.12 PIK47448.1 - 0.37 11.1 7.9 2.3 8.5 4.0 2.7 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Jnk-SapK_ap_N PF09744.9 PIK47448.1 - 0.41 10.9 9.4 0.66 10.2 9.4 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4404 PF14357.6 PIK47448.1 - 0.42 11.3 5.9 3.5 8.3 0.8 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) MBR1 PF17058.5 PIK47448.1 - 0.46 10.8 6.0 0.81 9.9 6.0 1.4 1 1 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 Snapin_Pallidin PF14712.6 PIK47448.1 - 0.49 10.9 13.8 0.73 10.3 6.7 2.6 2 1 1 3 3 2 0 Snapin/Pallidin bZIP_1 PF00170.21 PIK47448.1 - 0.52 10.4 10.0 3.3 7.9 0.2 3.1 1 1 2 3 3 3 0 bZIP transcription factor USP8_interact PF08941.10 PIK47448.1 - 0.53 10.1 5.6 0.62 9.9 4.6 1.6 1 1 0 1 1 1 0 USP8 interacting SseC PF04888.12 PIK47448.1 - 0.76 9.3 9.7 0.23 11.0 5.7 1.9 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family DUF2408 PF10303.9 PIK47448.1 - 0.82 10.2 5.9 1.3 9.5 5.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF16 PF01519.16 PIK47448.1 - 0.94 10.0 12.8 0.53 10.8 7.8 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4795 PF16043.5 PIK47448.1 - 0.94 9.0 15.1 4.6 6.8 15.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) LUC7 PF03194.15 PIK47448.1 - 0.99 9.0 9.8 3.2 7.3 6.3 1.8 1 1 1 2 2 2 0 LUC7 N_terminus Fzo_mitofusin PF04799.13 PIK47448.1 - 1 8.9 6.0 5.3 6.6 6.0 2.2 1 1 0 1 1 1 0 fzo-like conserved region MtrG PF04210.13 PIK47448.1 - 1.1 9.2 2.7 6.1 6.8 0.3 2.6 1 1 2 3 3 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF4460 PF14687.6 PIK47448.1 - 1.2 9.3 5.7 25 5.0 6.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4460) zf-C4H2 PF10146.9 PIK47448.1 - 1.2 9.4 7.9 2 8.7 7.9 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein CENP-H PF05837.12 PIK47448.1 - 1.2 9.5 10.2 0.5 10.8 7.1 1.8 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Uso1_p115_C PF04871.13 PIK47448.1 - 1.4 9.3 11.3 2 8.8 11.3 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF724 PF05266.14 PIK47448.1 - 1.5 8.6 11.4 12 5.7 11.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FAM76 PF16046.5 PIK47448.1 - 1.5 8.1 9.1 2.2 7.5 9.1 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4200 PF13863.6 PIK47448.1 - 1.6 9.1 10.4 4.1 7.8 5.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) HIP1_clath_bdg PF16515.5 PIK47448.1 - 2 9.1 10.8 2.3 8.9 7.4 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3782 PF12644.7 PIK47448.1 - 2.8 8.2 5.2 2.1e+02 2.2 5.2 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) Spc24 PF08286.11 PIK47448.1 - 3.8 7.8 12.8 22 5.4 0.7 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Ly49 PF08391.10 PIK47448.1 - 4.2 7.7 7.8 8.4 6.8 7.8 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Ax_dynein_light PF10211.9 PIK47448.1 - 4.3 7.2 10.4 16 5.4 10.4 1.8 1 1 0 1 1 1 0 Axonemal dynein light chain DivIC PF04977.15 PIK47448.1 - 4.9 7.0 8.6 0.98 9.2 2.0 2.5 1 1 2 3 3 3 0 Septum formation initiator YlbD_coat PF14071.6 PIK47448.1 - 5.2 7.3 14.8 4.1 7.7 8.8 2.3 1 1 1 2 2 2 0 Putative coat protein DASH_Dam1 PF08653.10 PIK47448.1 - 6.4 6.7 10.1 18 5.2 1.8 3.0 1 1 1 2 2 2 0 DASH complex subunit Dam1 Fungal_TACC PF12709.7 PIK47448.1 - 6.4 7.3 9.2 1 9.8 3.0 2.5 1 1 3 4 4 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins FlxA PF14282.6 PIK47448.1 - 6.8 6.7 14.1 6.5 6.8 9.4 2.7 1 1 1 2 2 2 0 FlxA-like protein Com_YlbF PF06133.11 PIK47448.1 - 8.2 7.1 14.3 35 5.1 14.3 2.0 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DUF4795 PF16043.5 PIK47449.1 - 2.6e-19 69.6 0.0 3.6e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) PARM PF17061.5 PIK47449.1 - 0.12 12.5 5.7 0.079 13.1 4.1 1.5 1 1 0 1 1 1 0 PARM Sulfotransfer_1 PF00685.27 PIK47450.1 - 1.7e-05 24.5 0.1 0.0031 17.0 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK47450.1 - 0.033 14.6 0.1 0.063 13.6 0.0 1.6 2 1 0 2 2 2 0 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK47450.1 - 0.05 13.5 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family tRNA-synt_1 PF00133.22 PIK47451.1 - 1.1e-28 99.9 0.1 1.3e-28 99.6 0.1 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 PIK47451.1 - 7.6e-14 51.3 0.0 1e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 PIK47451.1 - 0.0036 16.7 0.2 0.0055 16.1 0.1 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain TspO_MBR PF03073.15 PIK47452.1 - 1.3e-41 141.8 11.3 1.5e-41 141.6 11.3 1.0 1 0 0 1 1 1 1 TspO/MBR family Phage_int_SAM_4 PF13495.6 PIK47453.1 - 0.015 15.8 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK47453.1 - 0.022 15.0 1.5 0.04 14.2 0.1 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain PDEase_I PF00233.19 PIK47455.1 - 2.5e-33 115.8 0.1 2.6e-33 115.7 0.1 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I PF00233.19 PIK47456.1 - 3.4e-18 66.2 0.0 3.9e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Peptidase_C14 PF00656.22 PIK47457.1 - 1.3e-39 136.7 0.1 1.7e-39 136.3 0.1 1.1 1 0 0 1 1 1 1 Caspase domain WSC PF01822.19 PIK47458.1 - 2.2e-19 69.4 13.8 6.4e-11 42.3 2.5 2.1 2 0 0 2 2 2 2 WSC domain Peptidase_C14 PF00656.22 PIK47459.1 - 8.3e-15 55.4 0.0 1e-14 55.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 PIK47460.1 - 8.7e-17 61.9 0.0 1.1e-16 61.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Aldo_ket_red PF00248.21 PIK47461.1 - 0.00059 19.1 0.4 0.0014 17.9 0.2 1.8 1 1 1 2 2 2 1 Aldo/keto reductase family 7tm_2 PF00002.24 PIK47462.1 - 7.2e-21 74.6 21.5 1.6e-17 63.7 16.6 2.3 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) WSC PF01822.19 PIK47462.1 - 9.9e-16 57.7 15.8 5.6e-08 32.9 2.3 2.7 2 0 0 2 2 2 2 WSC domain GPS PF01825.21 PIK47462.1 - 2e-08 34.6 0.7 6.1e-08 33.1 0.7 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Transcrip_act PF04949.13 PIK47462.1 - 0.093 12.6 0.7 0.21 11.5 0.7 1.5 1 0 0 1 1 1 0 Transcriptional activator DUF4396 PF14342.6 PIK47462.1 - 0.74 10.2 11.8 5.1 7.4 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4396) Aldo_ket_red PF00248.21 PIK47463.1 - 7.2e-10 38.5 0.0 7.2e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AAA_12 PF13087.6 PIK47464.1 - 6.9e-44 149.8 0.0 1.2e-43 149.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK47464.1 - 1.2e-17 64.6 0.5 2.4e-12 47.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain S1-like PF14444.6 PIK47464.1 - 3.7e-17 62.0 2.8 1.6e-09 37.5 0.0 3.8 4 0 0 4 4 4 2 S1-like AAA_30 PF13604.6 PIK47464.1 - 2.8e-11 43.5 0.0 4.8e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK47464.1 - 3.1e-07 30.8 0.0 6.7e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK47464.1 - 0.001 19.1 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 PIK47464.1 - 0.0055 16.2 0.0 0.5 9.8 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 PIK47464.1 - 0.022 15.1 0.0 0.058 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Fip1 PF05182.13 PIK47464.1 - 0.057 12.9 0.1 3.7 7.1 0.0 2.5 2 0 0 2 2 2 0 Fip1 motif DUF1375 PF07119.12 PIK47464.1 - 0.074 13.5 0.2 0.23 11.9 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) AAA PF00004.29 PIK47464.1 - 0.077 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 PIK47464.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 PIK47464.1 - 0.15 11.4 0.0 7.3 5.8 0.0 2.9 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain IBR PF01485.21 PIK47465.1 - 3.1e-19 68.9 51.4 1.1e-12 48.0 11.0 3.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 PIK47465.1 - 0.0065 16.4 9.5 0.0065 16.4 9.5 4.3 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK47465.1 - 0.011 16.0 6.3 0.011 16.0 6.3 4.2 2 1 1 3 3 3 0 Ring finger domain ADIP PF11559.8 PIK47465.1 - 0.65 10.1 5.3 0.5 10.4 1.0 2.6 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Fibrinogen_C PF00147.18 PIK47467.1 - 6e-50 170.1 7.2 8.2e-50 169.6 7.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK47467.1 - 1.3e-43 147.1 185.4 1.6e-06 28.2 18.0 8.4 8 0 0 8 8 8 7 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 PIK47467.1 - 3.1e-10 39.8 58.1 0.41 10.6 4.7 9.8 8 0 0 8 8 8 8 Complement Clr-like EGF-like Tme5_EGF_like PF09064.10 PIK47467.1 - 2.2e-07 30.6 105.2 0.089 12.7 6.3 10.9 8 7 0 8 8 8 7 Thrombomodulin like fifth domain, EGF-like EGF_3 PF12947.7 PIK47467.1 - 9.9e-05 22.5 6.1 9.9e-05 22.5 6.1 9.9 8 0 0 8 8 8 1 EGF domain RICTOR_V PF14668.6 PIK47467.1 - 0.00011 22.4 0.1 19 5.6 0.0 6.1 7 0 0 7 7 7 0 Rapamycin-insensitive companion of mTOR, domain 5 Ribosomal_S5_C PF03719.15 PIK47467.1 - 0.00034 20.0 0.0 49 3.5 0.0 5.6 6 0 0 6 6 6 0 Ribosomal protein S5, C-terminal domain EGF_2 PF07974.13 PIK47467.1 - 0.0018 18.6 6.1 0.0018 18.6 6.1 13.2 9 7 0 9 9 9 1 EGF-like domain EGF_MSP1_1 PF12946.7 PIK47467.1 - 0.0067 16.5 2.6 0.0067 16.5 2.6 9.2 8 0 0 8 8 8 1 MSP1 EGF domain 1 EGF PF00008.27 PIK47467.1 - 0.15 12.4 101.6 0.3 11.4 4.5 11.3 8 0 0 8 8 8 0 EGF-like domain Peptidase_M24 PF00557.24 PIK47468.1 - 3.4e-44 151.0 0.2 4.9e-44 150.5 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PI3K_1B_p101 PF10486.9 PIK47468.1 - 0.63 7.7 9.4 0.77 7.5 9.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SRP-alpha_N PF04086.13 PIK47468.1 - 5.5 6.8 22.0 8.5 6.2 22.0 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal LZ_Tnp_IS66 PF13007.7 PIK47468.1 - 6.2 7.7 14.2 9.5 7.1 3.0 2.6 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain SRP72 PF08492.12 PIK47468.1 - 7.5 7.1 20.7 12 6.4 5.9 2.7 2 0 0 2 2 2 0 SRP72 RNA-binding domain Drc1-Sld2 PF11719.8 PIK47468.1 - 8.5 5.8 25.8 14 5.0 25.8 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Peptidase_C1 PF00112.23 PIK47469.1 - 2.6e-52 178.1 1.5 4.7e-52 177.2 1.5 1.4 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 PIK47469.1 - 2.4e-41 140.8 0.5 4.9e-41 139.8 0.5 1.5 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 PIK47469.1 - 4.6e-06 25.7 0.7 5e-05 22.3 0.1 2.1 2 0 0 2 2 2 1 Peptidase C1-like family Propeptide_C1 PF08127.13 PIK47469.1 - 0.035 14.0 0.3 0.073 13.0 0.3 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide DUF1690 PF07956.11 PIK47470.1 - 7e-05 23.3 9.5 0.0003 21.2 9.5 1.8 1 1 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF737 PF05300.11 PIK47470.1 - 0.00024 21.5 7.2 0.0012 19.3 3.9 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF737) CX9C PF16860.5 PIK47470.1 - 0.0053 16.7 2.2 0.83 9.7 0.1 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 PIK47470.1 - 0.0071 16.5 2.8 0.0071 16.5 2.8 1.6 2 0 0 2 2 2 1 CHCH domain RNase_HII PF01351.18 PIK47470.1 - 0.018 14.9 0.4 0.021 14.7 0.4 1.1 1 0 0 1 1 1 0 Ribonuclease HII C_GCAxxG_C_C PF09719.10 PIK47470.1 - 0.04 14.2 2.5 0.057 13.7 2.5 1.2 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) Cmc1 PF08583.10 PIK47470.1 - 0.19 11.7 2.9 5.4 7.1 0.1 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like RabGAP-TBC PF00566.18 PIK47471.1 - 6.4e-37 127.3 2.5 1.2e-36 126.5 0.3 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF4682 PF15733.5 PIK47471.1 - 4e-08 33.9 19.5 4.2e-07 30.6 19.5 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4682) Peptidase_S49_N PF08496.10 PIK47471.1 - 2.8 8.0 4.4 1.9 8.5 0.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NTR PF01759.21 PIK47472.1 - 0.0016 18.2 0.0 0.0021 17.8 0.0 1.1 1 0 0 1 1 1 1 UNC-6/NTR/C345C module SpoIISA_toxin PF14171.6 PIK47472.1 - 0.0091 15.7 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Toxin SpoIISA, type II toxin-antitoxin system TIMP PF00965.17 PIK47472.1 - 0.029 14.2 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase DUF2890 PF11081.8 PIK47472.1 - 0.14 12.2 0.1 0.17 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) UPF0239 PF06783.11 PIK47474.1 - 4e-12 46.1 0.0 4.7e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0239) GTSE1_N PF15259.6 PIK47475.1 - 1.4e-19 70.8 13.0 2e-14 54.0 1.8 3.0 2 1 1 3 3 3 2 G-2 and S-phase expressed 1 7tm_1 PF00001.21 PIK47476.1 - 1.4e-21 77.0 10.4 1.8e-21 76.6 10.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK47476.1 - 1.7e-07 31.2 16.8 2.1e-07 30.8 16.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK47476.1 - 0.00045 20.0 2.4 0.011 15.5 0.4 2.5 1 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK47476.1 - 0.016 14.6 10.3 0.021 14.2 10.3 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx ORC5_C PF14630.6 PIK47477.1 - 5.2e-67 226.3 2.0 6.9e-67 226.0 2.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 PIK47477.1 - 1.2e-08 35.6 0.0 3.5e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK47477.1 - 1.4e-05 25.4 0.1 0.00019 21.7 0.1 2.5 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 PIK47477.1 - 0.00073 19.5 0.0 0.018 14.9 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea PIF1 PF05970.14 PIK47477.1 - 0.0032 16.7 0.0 0.014 14.5 0.0 1.9 2 0 0 2 2 2 1 PIF1-like helicase Sigma54_activat PF00158.26 PIK47477.1 - 0.05 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain EGF_2 PF07974.13 PIK47479.1 - 1.1e-10 41.7 55.6 0.00019 21.7 15.6 3.9 3 0 0 3 3 3 3 EGF-like domain BNR PF02012.20 PIK47479.1 - 6e-05 22.4 6.5 6.8 7.1 0.0 5.2 4 0 0 4 4 4 2 BNR/Asp-box repeat EGF_Tenascin PF18720.1 PIK47479.1 - 0.00021 21.3 31.9 0.25 11.4 8.4 4.1 3 0 0 3 3 3 3 Tenascin EGF domain EB PF01683.18 PIK47479.1 - 0.00063 20.0 27.6 0.19 12.1 4.3 4.0 4 0 0 4 4 4 3 EB module hEGF PF12661.7 PIK47479.1 - 0.0042 17.7 38.9 0.14 12.8 9.6 4.2 3 0 0 3 3 3 2 Human growth factor-like EGF EGF PF00008.27 PIK47479.1 - 0.043 14.1 46.2 0.83 10.0 12.7 3.7 3 0 0 3 3 3 0 EGF-like domain CHB_HEX_C PF03174.13 PIK47479.1 - 0.13 12.3 0.1 28 4.8 0.0 4.1 5 0 0 5 5 5 0 Chitobiase/beta-hexosaminidase C-terminal domain EGF_2 PF07974.13 PIK47481.1 - 5.7e-14 52.2 91.7 0.00045 20.5 9.3 5.9 5 0 0 5 5 5 5 EGF-like domain BNR PF02012.20 PIK47481.1 - 1.1e-12 45.9 22.3 0.083 12.9 0.1 9.2 9 0 0 9 9 9 6 BNR/Asp-box repeat EGF_Tenascin PF18720.1 PIK47481.1 - 3.7e-06 26.9 72.6 0.02 14.9 6.5 6.5 6 0 0 6 6 6 5 Tenascin EGF domain hEGF PF12661.7 PIK47481.1 - 3.3e-05 24.3 77.5 0.063 13.9 7.1 7.4 7 0 0 7 7 7 5 Human growth factor-like EGF EB PF01683.18 PIK47481.1 - 4.4e-05 23.7 44.9 0.00081 19.6 3.8 5.9 5 0 0 5 5 5 4 EB module Sortilin-Vps10 PF15902.5 PIK47481.1 - 0.13 11.0 1.0 40 2.8 0.0 4.5 6 0 0 6 6 6 0 Sortilin, neurotensin receptor 3, EGF PF00008.27 PIK47481.1 - 0.14 12.5 85.0 0.062 13.6 12.8 6.6 6 1 0 6 6 6 0 EGF-like domain TraB PF01963.17 PIK47482.1 - 2.4e-22 80.1 0.0 8.2e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 TraB family Lyase_aromatic PF00221.19 PIK47483.1 - 1.2e-174 581.4 0.9 1.6e-173 577.7 0.9 1.9 1 1 0 1 1 1 1 Aromatic amino acid lyase 7tm_1 PF00001.21 PIK47484.1 - 4.5e-30 104.9 14.1 5.4e-30 104.6 14.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK47484.1 - 6.8e-07 28.9 12.9 1.3e-06 28.0 12.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK47484.1 - 0.00084 19.2 9.0 0.0052 16.6 5.6 2.2 2 0 0 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 PIK47485.1 - 3.3e-30 105.3 12.5 3.9e-30 105.0 12.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK47485.1 - 6.1e-07 29.1 13.9 1.5e-06 27.8 13.9 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RVT_1 PF00078.27 PIK47487.1 - 2.3e-14 53.5 0.0 3.8e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2207 PF09972.9 PIK47487.1 - 5.9e-05 22.0 6.6 7e-05 21.8 6.6 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) AA_permease_2 PF13520.6 PIK47487.1 - 0.00059 18.8 18.2 0.00072 18.5 18.2 1.1 1 0 0 1 1 1 1 Amino acid permease Wzy_C PF04932.15 PIK47487.1 - 0.21 11.2 9.8 0.43 10.2 9.8 1.7 1 0 0 1 1 1 0 O-Antigen ligase TraG_N PF07916.11 PIK47487.1 - 6 5.6 10.0 8.5 5.1 10.0 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region MFS_1 PF07690.16 PIK47488.1 - 1.3e-18 67.1 8.1 1.3e-18 67.1 8.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 PIK47489.1 - 8.4e-05 21.6 0.0 8.6e-05 21.6 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DOCK-C2 PF14429.6 PIK47490.1 - 1.9e-24 86.5 0.1 3.7e-24 85.6 0.1 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins RIH_assoc PF08454.11 PIK47491.1 - 0.029 14.2 0.4 0.25 11.2 0.0 2.7 3 1 0 3 3 3 0 RyR and IP3R Homology associated ECM11 PF15463.6 PIK47491.1 - 0.045 14.3 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Extracellular mutant protein 11 DHR-2 PF06920.13 PIK47492.1 - 6.5e-18 64.7 0.0 8.4e-18 64.3 0.0 1.0 1 0 0 1 1 1 1 Dock homology region 2 CENP-K PF11802.8 PIK47494.1 - 2.6e-38 132.1 11.5 3.1e-38 131.9 11.5 1.0 1 0 0 1 1 1 1 Centromere-associated protein K DivIVA PF05103.13 PIK47494.1 - 0.00053 20.1 6.9 0.0012 18.9 6.9 1.6 1 0 0 1 1 1 1 DivIVA protein SKA1 PF07160.12 PIK47494.1 - 0.0061 16.4 7.3 0.009 15.9 7.3 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 DUF3584 PF12128.8 PIK47494.1 - 0.019 12.5 8.9 0.024 12.2 8.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 PIK47494.1 - 0.048 13.8 15.4 0.072 13.2 15.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 PIK47494.1 - 0.051 13.6 10.5 0.12 12.4 10.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Baculo_p24 PF05073.12 PIK47494.1 - 0.13 12.0 4.9 0.21 11.4 4.9 1.4 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Macoilin PF09726.9 PIK47494.1 - 0.13 10.7 6.9 0.16 10.5 6.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF2570 PF10828.8 PIK47494.1 - 0.14 12.0 8.1 0.24 11.2 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) CENP-Q PF13094.6 PIK47494.1 - 0.18 12.0 13.8 0.13 12.5 10.1 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Muted PF14942.6 PIK47494.1 - 0.2 12.0 13.5 0.32 11.3 13.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Mst1_SARAH PF11629.8 PIK47494.1 - 0.27 11.3 3.9 2.9 8.0 0.1 2.7 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Exonuc_VII_L PF02601.15 PIK47494.1 - 0.77 9.3 6.9 0.94 9.0 6.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 PIK47494.1 - 1.2 9.3 9.5 3.1 8.0 9.5 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 PIK47494.1 - 1.3 9.0 17.6 9.9 6.2 17.5 2.4 1 1 1 2 2 2 0 Prefoldin subunit Nas2_N PF18265.1 PIK47494.1 - 1.4 8.9 7.9 14 5.7 0.0 3.4 2 1 1 3 3 3 0 Nas2 N_terminal domain ApoO PF09769.9 PIK47494.1 - 1.9 8.4 4.2 10 6.1 0.9 2.1 1 1 1 2 2 2 0 Apolipoprotein O OmpH PF03938.14 PIK47494.1 - 5 7.5 14.0 8.9 6.7 14.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MotA_ExbB PF01618.16 PIK47494.1 - 9.2 6.0 7.4 4.4 7.1 0.2 2.5 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family Lzipper-MIP1 PF14389.6 PIK47494.1 - 9.7 6.6 20.0 0.68 10.3 7.7 3.3 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Tim17 PF02466.19 PIK47495.1 - 4e-25 88.3 3.7 5.3e-25 88.0 3.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ADH_zinc_N_2 PF13602.6 PIK47496.1 - 6.6e-10 40.2 0.0 6.6e-10 40.2 0.0 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK47497.1 - 1.9e-12 47.0 0.0 7.3e-12 45.1 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain 7tm_1 PF00001.21 PIK47498.1 - 3e-34 118.6 5.2 4.3e-34 118.0 5.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK47498.1 - 0.00068 19.3 18.6 0.00068 19.3 18.6 2.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Y_phosphatase PF00102.27 PIK47499.1 - 2.6e-58 197.4 0.1 3.4e-58 197.0 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK47499.1 - 4.1e-06 26.9 0.0 6.4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK47499.1 - 0.00029 21.0 0.0 0.00074 19.7 0.0 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 PIK47499.1 - 0.0007 19.4 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Herpes_capsid PF06112.11 PIK47499.1 - 9.9 6.2 15.9 9.2 6.3 11.7 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Peptidase_C23 PF05379.11 PIK47500.1 - 0.067 13.3 2.7 16 5.7 0.0 3.8 3 0 0 3 3 3 0 Carlavirus endopeptidase DUF3316 PF11777.8 PIK47500.1 - 2.7 8.1 8.2 0.9 9.6 1.2 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3316) DUF4541 PF15074.6 PIK47501.1 - 3.6e-06 27.5 1.0 4.9e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4541) FAM183 PF14886.6 PIK47501.1 - 0.00057 20.6 4.8 0.011 16.5 4.8 2.4 1 1 0 1 1 1 1 FAM183A and FAM183B related mTERF PF02536.14 PIK47501.1 - 0.022 13.7 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 mTERF Hemerythrin PF01814.23 PIK47502.1 - 0.036 14.7 0.0 0.038 14.6 0.0 1.0 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain F-box-like PF12937.7 PIK47503.1 - 1e-17 63.7 1.8 1.9e-17 62.8 1.8 1.5 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 PIK47503.1 - 1e-10 41.6 0.4 0.00027 21.2 0.3 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) F-box PF00646.33 PIK47503.1 - 4.3e-10 39.2 0.2 1.3e-09 37.7 0.2 1.8 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 PIK47503.1 - 3.7e-08 32.8 3.8 0.0072 16.3 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 PIK47503.1 - 0.0016 18.7 2.7 10 7.1 0.1 4.5 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_8 PF13855.6 PIK47503.1 - 0.039 13.7 2.1 2.8 7.8 0.2 3.7 2 2 0 2 2 2 0 Leucine rich repeat tRNA-synt_1c PF00749.21 PIK47504.1 - 4.4e-111 370.7 0.0 4.4e-111 370.7 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 PIK47504.1 - 2.4e-50 170.7 0.3 6.3e-50 169.3 0.0 1.8 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 PIK47504.1 - 2.1e-49 167.8 0.0 4.4e-49 166.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 PIK47504.1 - 2.2e-28 99.0 10.8 4.4e-28 98.0 10.8 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Pox_Ag35 PF03286.14 PIK47504.1 - 0.053 13.3 5.0 0.094 12.5 5.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Neur_chan_LBD PF02931.23 PIK47505.1 - 2.2e-26 92.7 1.2 3e-26 92.2 1.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK47505.1 - 2.4e-05 24.5 5.5 3.5e-05 24.0 5.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_S12 PF17487.2 PIK47505.1 - 0.075 13.8 3.0 0.09 13.5 0.4 2.4 2 0 0 2 2 2 0 Ribosomal protein S12 CopD PF05425.13 PIK47505.1 - 0.1 13.0 1.2 5.4 7.5 0.0 2.2 1 1 0 2 2 2 0 Copper resistance protein D YjeJ PF15922.5 PIK47505.1 - 0.17 11.1 0.1 5.4 6.1 0.0 2.1 1 1 1 2 2 2 0 YjeJ-like Neur_chan_LBD PF02931.23 PIK47506.1 - 2.8e-17 62.9 1.8 3.8e-17 62.5 1.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK47506.1 - 5.5e-05 23.4 4.7 8.5e-05 22.7 4.7 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_S12 PF17487.2 PIK47506.1 - 0.068 13.9 0.6 0.068 13.9 0.6 2.0 2 0 0 2 2 2 0 Ribosomal protein S12 Neur_chan_LBD PF02931.23 PIK47507.1 - 4.3e-30 104.8 0.2 5.2e-30 104.5 0.2 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 PIK47508.1 - 1.3e-37 129.4 2.4 1.5e-37 129.1 2.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK47508.1 - 0.13 12.3 5.0 0.18 11.9 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region L1R_F9L PF02442.17 PIK47508.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses Neur_chan_LBD PF02931.23 PIK47509.1 - 1.3e-38 132.6 2.5 1.6e-38 132.3 2.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK47509.1 - 0.00027 21.1 3.3 0.0004 20.5 3.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_S12 PF17487.2 PIK47509.1 - 0.16 12.7 0.4 0.16 12.7 0.4 2.0 2 0 0 2 2 2 0 Ribosomal protein S12 NACHT PF05729.12 PIK47511.1 - 0.0016 18.4 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 NACHT domain DED PF01335.21 PIK47511.1 - 0.02 15.2 0.1 0.036 14.4 0.1 1.5 1 0 0 1 1 1 0 Death effector domain Ribosomal_L5 PF00281.19 PIK47511.1 - 0.16 12.3 0.2 0.55 10.6 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L5 Rotavirus_VP7 PF05868.11 PIK47512.1 - 0.00026 20.5 0.5 0.00092 18.7 0.1 1.9 2 0 0 2 2 2 1 Rotavirus major outer capsid protein VP7 ERM PF00769.19 PIK47513.1 - 3.8e-05 23.6 33.3 3.8e-05 23.6 33.3 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family GAS PF13851.6 PIK47513.1 - 9.1e-05 21.9 68.0 0.00042 19.7 28.6 2.9 1 1 2 3 3 3 3 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK47513.1 - 0.002 18.7 30.3 0.002 18.7 30.3 3.5 1 1 2 3 3 3 2 Apg6 coiled-coil region TACC_C PF05010.14 PIK47513.1 - 0.033 14.0 56.5 0.085 12.6 30.1 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 PIK47513.1 - 0.048 13.7 35.7 0.13 12.3 5.6 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Lebercilin PF15619.6 PIK47513.1 - 0.19 11.3 67.7 0.023 14.4 45.5 3.5 1 1 1 2 2 1 0 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 PIK47513.1 - 0.21 12.2 65.7 0.38 11.4 6.1 4.2 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 T3SSipB PF16535.5 PIK47513.1 - 0.25 11.8 41.1 7.8 6.9 14.4 3.2 1 1 1 2 2 2 0 Type III cell invasion protein SipB MAP65_ASE1 PF03999.12 PIK47513.1 - 0.57 8.8 47.1 0.78 8.4 47.1 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) HMMR_N PF15905.5 PIK47513.1 - 0.99 8.8 60.9 1.1 8.7 25.9 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 PIK47513.1 - 1 8.1 62.2 16 4.2 37.5 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Laminin_II PF06009.12 PIK47513.1 - 1.2 9.2 34.7 0.13 12.3 11.5 3.3 1 1 2 3 3 3 0 Laminin Domain II UPA_2 PF17809.1 PIK47513.1 - 1.2 8.9 4.4 1.8 8.4 0.1 2.8 1 1 2 3 3 3 0 UPA domain PilA4 PF18682.1 PIK47513.1 - 2.3 8.7 5.4 60 4.1 0.0 3.8 2 1 2 5 5 4 0 Pilin A4 DUF2353 PF09789.9 PIK47513.1 - 2.9 7.2 51.4 1.7 7.9 23.8 2.9 1 1 2 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) DUF4726 PF15855.5 PIK47513.1 - 3.9 7.8 12.7 8.2 6.7 0.7 4.2 1 1 3 4 4 4 0 Domain of unknown function (DUF4726) NAPRTase_N PF17767.1 PIK47513.1 - 6.7 7.1 15.1 30 5.0 2.8 3.6 1 1 2 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Fez1 PF06818.15 PIK47513.1 - 8.4 6.8 59.3 1.1 9.7 37.7 2.5 1 1 1 2 2 2 0 Fez1 DUF4472 PF14739.6 PIK47513.1 - 9.6 7.0 54.7 0.095 13.4 14.5 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4472) ZU5 PF00791.20 PIK47515.1 - 5.9e-05 23.4 0.0 0.031 14.6 0.0 3.3 2 0 0 2 2 2 2 ZU5 domain DED PF01335.21 PIK47515.1 - 0.02 15.2 0.1 0.3 11.4 0.1 2.4 2 0 0 2 2 2 0 Death effector domain HCO3_cotransp PF00955.21 PIK47516.1 - 1.9e-187 624.2 11.0 2.6e-187 623.7 11.0 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 PIK47516.1 - 4.8e-29 102.0 0.2 1e-13 51.8 0.0 2.3 1 1 1 2 2 2 2 Band 3 cytoplasmic domain CWC25 PF12542.8 PIK47519.1 - 2.2e-16 60.6 2.3 2.2e-16 60.6 2.3 4.3 2 1 0 2 2 2 1 Pre-mRNA splicing factor DUF755 PF05501.11 PIK47519.1 - 0.024 14.9 14.3 0.024 14.9 14.3 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF755) MAP17 PF15807.5 PIK47520.1 - 0.33 11.2 3.4 0.37 11.0 3.4 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PTB PF08416.13 PIK47521.1 - 7.7e-30 103.7 0.0 1.7e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PTEN_C2 PF10409.9 PIK47521.1 - 2.9e-28 98.3 0.0 7.6e-28 96.9 0.0 1.8 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH2 PF00017.24 PIK47521.1 - 4.9e-10 39.4 0.0 1.1e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 SH2 domain RVT_1 PF00078.27 PIK47522.1 - 4.3e-13 49.3 0.2 6.3e-13 48.8 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spy1 PF11357.8 PIK47522.1 - 0.031 14.6 0.0 0.089 13.1 0.0 1.7 1 1 1 2 2 2 0 Cell cycle regulatory protein NAGidase PF07555.13 PIK47522.1 - 0.041 13.2 0.0 0.051 12.9 0.0 1.1 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase GAS PF13851.6 PIK47524.1 - 4e-08 32.9 71.4 2.7e-06 26.9 34.7 3.0 1 1 2 3 3 3 2 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK47524.1 - 2.4e-07 30.9 79.1 0.00048 20.0 50.0 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK47524.1 - 0.0016 18.9 81.8 0.15 12.6 32.4 3.6 1 1 1 2 2 2 1 Apg6 coiled-coil region TPD52 PF04201.15 PIK47524.1 - 0.2 11.3 57.2 0.68 9.5 3.9 5.5 1 1 6 7 7 7 0 Tumour protein D52 family PilA4 PF18682.1 PIK47524.1 - 0.2 12.1 16.2 38 4.8 0.3 5.7 2 1 2 5 5 5 0 Pilin A4 Fez1 PF06818.15 PIK47524.1 - 0.42 11.0 65.9 0.12 12.8 47.3 2.5 1 1 1 2 2 2 0 Fez1 DUF4472 PF14739.6 PIK47524.1 - 0.45 11.3 65.1 0.39 11.5 15.7 4.8 3 1 3 6 6 5 0 Domain of unknown function (DUF4472) Cep57_MT_bd PF06657.13 PIK47524.1 - 0.59 10.6 50.7 1.3 9.6 12.3 5.3 2 1 3 6 6 6 0 Centrosome microtubule-binding domain of Cep57 bZIP_1 PF00170.21 PIK47524.1 - 0.79 9.9 57.3 0.39 10.8 7.6 5.6 4 1 1 5 5 5 0 bZIP transcription factor FmiP_Thoc5 PF09766.9 PIK47524.1 - 2.1 7.5 58.7 2.1 7.5 27.4 3.1 1 1 2 3 3 3 0 Fms-interacting protein/Thoc5 Lebercilin PF15619.6 PIK47524.1 - 2.2 7.9 76.9 0.19 11.4 16.6 3.8 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease HBM PF16591.5 PIK47524.1 - 2.8 7.3 43.8 19 4.6 40.5 2.9 1 1 1 2 2 2 0 Helical bimodular sensor domain T3SSipB PF16535.5 PIK47524.1 - 5 7.6 43.4 12 6.4 9.2 3.7 1 1 1 2 2 2 0 Type III cell invasion protein SipB FPP PF05911.11 PIK47524.1 - 5.3 5.1 56.4 16 3.5 40.8 3.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Sipho_Gp157 PF05565.11 PIK47524.1 - 6.6 6.7 47.7 1.4 8.9 6.5 4.5 1 1 3 4 4 4 0 Siphovirus Gp157 KASH_CCD PF14662.6 PIK47524.1 - 8.9 6.1 70.9 27 4.5 44.5 3.9 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH RT_RNaseH_2 PF17919.1 PIK47525.1 - 5.4e-32 109.8 0.0 1.7e-31 108.2 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47525.1 - 5.2e-28 97.4 0.0 3.2e-27 94.9 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47525.1 - 6.9e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_4 PF13359.6 PIK47526.1 - 5.3e-24 84.7 0.0 6.4e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK47526.1 - 0.001 18.7 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein zf-CCHC PF00098.23 PIK47527.1 - 7.1e-08 32.2 15.8 0.00034 20.6 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK47527.1 - 0.00017 21.4 8.1 0.049 13.5 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK47527.1 - 0.005 16.6 11.1 2.5 7.9 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK47527.1 - 0.0067 16.4 16.4 0.093 12.7 0.9 3.7 2 1 2 4 4 4 2 Zinc knuckle zf-C2H2_10 PF16588.5 PIK47527.1 - 0.011 15.4 0.8 0.011 15.4 0.8 2.7 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 PIK47527.1 - 0.011 15.5 0.2 0.011 15.5 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK47528.1 - 9.7e-35 118.6 0.1 3.2e-34 117.0 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47528.1 - 7e-30 103.4 0.0 2e-29 102.0 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47528.1 - 8.2e-19 68.0 0.0 1.6e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK47528.1 - 1.2e-16 60.9 0.0 6.2e-16 58.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK47528.1 - 2.6e-16 59.5 1.3 2.6e-16 59.5 1.3 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 PIK47528.1 - 0.0041 17.7 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK47528.1 - 0.0049 16.9 3.0 0.014 15.5 3.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK47528.1 - 0.0091 15.7 2.1 0.0091 15.7 2.1 2.1 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger gag-asp_proteas PF13975.6 PIK47528.1 - 0.011 16.2 0.0 0.036 14.6 0.0 1.9 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 PIK47528.1 - 0.015 15.5 0.2 0.061 13.6 0.2 2.2 1 0 0 1 1 1 0 H2C2 zinc finger KxDL PF10241.9 PIK47528.1 - 0.031 14.5 0.0 0.22 11.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein zinc-ribbons_6 PF07191.12 PIK47528.1 - 4.8 7.2 7.8 0.99 9.4 3.0 2.3 2 0 0 2 2 2 0 zinc-ribbons THAP PF05485.12 PIK47529.1 - 2.8e-08 34.6 0.3 2.8e-08 34.6 0.3 1.9 2 0 0 2 2 2 1 THAP domain MRG PF05712.13 PIK47529.1 - 0.089 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 MRG RVT_1 PF00078.27 PIK47530.1 - 1.3e-10 41.1 0.0 0.00016 21.2 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) NPA PF16469.5 PIK47531.1 - 0.039 14.5 0.2 0.086 13.4 0.2 1.7 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 SNX17_FERM_C PF18116.1 PIK47533.1 - 8.5e-35 119.1 0.0 1.5e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PX PF00787.24 PIK47533.1 - 3.2e-10 40.0 0.9 7.7e-09 35.5 0.2 2.5 2 0 0 2 2 2 1 PX domain RA PF00788.23 PIK47533.1 - 2.9e-05 24.6 0.0 5.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain MFS_1 PF07690.16 PIK47534.1 - 2.9e-29 102.1 45.4 1.5e-23 83.4 17.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ig_2 PF13895.6 PIK47535.1 - 2.4e-12 47.0 3.5 4.3e-06 27.0 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.6 PIK47535.1 - 4.1e-12 46.5 0.6 3e-07 30.9 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK47535.1 - 1e-10 41.6 0.5 1.7e-06 28.1 0.0 3.3 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK47535.1 - 1.9e-07 31.1 0.2 0.0034 17.4 0.0 3.3 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK47535.1 - 0.00014 22.0 0.9 0.083 13.1 0.1 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK47537.1 - 3e-35 121.8 0.0 4e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47537.1 - 4e-19 69.0 0.1 6.6e-19 68.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Peptidase_S49_N PF08496.10 PIK47537.1 - 0.19 11.8 0.1 0.46 10.5 0.1 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pkinase_Tyr PF07714.17 PIK47538.1 - 8.6e-44 149.8 0.0 1.1e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47538.1 - 6.7e-16 58.4 0.0 9.7e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ECSCR PF15820.5 PIK47538.1 - 0.046 13.5 2.6 0.26 11.1 1.0 2.6 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator Pkinase_Tyr PF07714.17 PIK47539.1 - 3.2e-37 128.2 0.0 5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47539.1 - 5.3e-15 55.5 0.0 9.1e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK47539.1 - 0.00052 20.0 0.2 0.0017 18.4 0.2 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK47539.1 - 0.0012 19.0 1.2 0.065 13.4 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK47539.1 - 0.0029 18.2 3.6 0.66 10.6 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK47539.1 - 0.014 15.5 0.5 6.4 6.9 0.0 3.4 3 0 0 3 3 3 0 Immunoglobulin I-set domain ig PF00047.25 PIK47539.1 - 0.68 10.1 5.0 7.2 6.9 1.7 3.4 2 1 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK47540.1 - 5.3e-28 98.0 0.2 7.9e-28 97.4 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47540.1 - 2e-14 53.6 0.0 3.9e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DrsE_2 PF13686.6 PIK47540.1 - 0.0082 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 DsrE/DsrF/DrsH-like family NACHT PF05729.12 PIK47541.1 - 1.1e-18 67.8 0.1 2.1e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK47541.1 - 4.9e-05 22.7 0.3 0.00011 21.5 0.3 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 PIK47541.1 - 0.015 15.7 0.0 0.22 11.9 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain DUF5615 PF18480.1 PIK47541.1 - 0.04 13.7 0.2 13 5.6 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) IstB_IS21 PF01695.17 PIK47541.1 - 0.049 13.4 0.1 0.29 10.8 0.0 2.2 2 1 0 2 2 2 0 IstB-like ATP binding protein C2-set_2 PF08205.12 PIK47541.1 - 0.05 13.7 1.0 0.13 12.4 1.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK47541.1 - 0.054 13.7 0.3 0.41 10.8 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin V-set domain DUF4403 PF14356.6 PIK47541.1 - 0.063 11.9 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) ig PF00047.25 PIK47541.1 - 0.076 13.2 1.2 0.32 11.2 0.2 2.6 3 0 0 3 3 3 0 Immunoglobulin domain AAA_14 PF13173.6 PIK47541.1 - 0.086 12.9 0.8 0.33 11.0 0.5 2.2 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 PIK47541.1 - 0.1 12.6 0.2 0.32 11.0 0.2 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK47541.1 - 0.15 11.8 0.1 1.2 8.9 0.0 2.3 2 1 0 3 3 3 0 DEAD/DEAH box helicase C2-set_2 PF08205.12 PIK47542.1 - 1e-06 28.7 0.0 3.7e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK47542.1 - 1.6e-06 28.6 5.7 0.018 15.6 0.1 3.1 3 1 0 3 3 3 2 Immunoglobulin domain TMEM154 PF15102.6 PIK47542.1 - 1.8e-05 24.7 3.0 1.8e-05 24.7 0.4 2.2 2 0 0 2 2 2 1 TMEM154 protein family ig PF00047.25 PIK47542.1 - 0.00013 22.0 7.0 0.014 15.5 0.1 3.0 3 1 0 3 3 3 2 Immunoglobulin domain DUF4448 PF14610.6 PIK47542.1 - 0.00047 20.0 0.6 0.001 18.9 0.2 1.7 2 1 0 2 2 2 1 Protein of unknown function (DUF4448) I-set PF07679.16 PIK47542.1 - 0.00048 20.1 7.0 0.19 11.8 0.3 3.4 3 1 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 PIK47542.1 - 0.0089 16.4 0.9 0.11 12.9 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Protocadherin PF08374.11 PIK47542.1 - 0.014 15.3 0.7 5.8 6.8 0.1 2.2 2 0 0 2 2 2 0 Protocadherin RGI_lyase PF18370.1 PIK47542.1 - 0.084 13.2 0.5 0.71 10.2 0.0 2.6 3 0 0 3 3 3 0 Rhamnogalacturonan I lyases beta-sheet domain rve PF00665.26 PIK47543.1 - 2.6e-25 88.9 0.0 4.3e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK47543.1 - 5.7e-23 80.8 0.7 9.8e-23 80.0 0.7 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK47543.1 - 5.6e-05 22.8 0.1 0.00014 21.6 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK47543.1 - 0.0018 18.5 0.4 0.0059 16.8 0.3 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RVT_1 PF00078.27 PIK47544.1 - 3.8e-20 72.4 0.0 6.3e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK47544.1 - 0.0019 18.2 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pkinase PF00069.25 PIK47545.1 - 1.3e-30 106.6 0.1 2.3e-30 105.9 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47545.1 - 1.8e-23 83.2 0.1 2.9e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK47545.1 - 0.00044 19.1 0.0 0.00072 18.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK47545.1 - 0.026 13.5 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase I-set PF07679.16 PIK47546.1 - 1e-51 172.9 2.3 5.7e-14 52.0 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK47546.1 - 8.1e-45 151.3 8.2 6e-12 46.0 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 PIK47546.1 - 3.9e-30 104.0 2.7 7.5e-09 35.8 0.0 5.6 6 0 0 6 6 6 4 Immunoglobulin domain ig PF00047.25 PIK47546.1 - 3.8e-25 87.9 6.4 2.2e-07 30.9 0.4 5.6 5 1 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.21 PIK47546.1 - 2.3e-22 79.1 0.1 1.6e-12 47.6 0.0 3.3 3 0 0 3 3 3 2 Fibronectin type III domain V-set PF07686.17 PIK47546.1 - 6.7e-20 71.3 10.3 3.8e-05 23.8 1.0 7.2 5 3 1 6 6 6 4 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK47546.1 - 1.5e-08 34.6 0.3 1.3 9.2 0.0 5.0 4 1 1 5 5 5 3 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK47546.1 - 2.6e-08 34.1 0.6 1.3 9.5 0.0 5.6 5 1 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK47546.1 - 9e-07 28.4 0.0 0.17 11.5 0.0 5.0 5 0 0 5 5 5 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK47546.1 - 5.1e-06 26.5 1.7 0.16 12.1 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK47546.1 - 1.3e-05 25.6 0.2 0.00028 21.4 0.2 3.2 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C2-set PF05790.15 PIK47546.1 - 0.00021 21.4 0.3 8.4 6.7 0.0 5.2 6 1 0 6 6 6 1 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 PIK47546.1 - 0.00035 20.6 0.1 2.6 8.1 0.0 4.2 5 0 0 5 5 5 1 CD47 immunoglobulin-like domain PhoD_N PF16655.5 PIK47546.1 - 0.019 15.5 0.0 0.061 13.9 0.0 1.8 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Egh16-like PF11327.8 PIK47546.1 - 0.034 14.6 0.0 5.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Egh16-like virulence factor Pou PF00157.17 PIK47548.1 - 1.1e-37 127.8 0.1 1.1e-37 127.8 0.1 3.3 4 0 0 4 4 4 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK47548.1 - 1.7e-17 63.0 1.3 1.7e-17 63.0 1.3 2.8 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 PIK47548.1 - 0.031 14.2 0.0 0.13 12.2 0.0 2.2 1 0 0 1 1 1 0 Homeobox KN domain HTH_3 PF01381.22 PIK47548.1 - 0.086 12.9 0.0 2.1 8.5 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix CBFB_NFYA PF02045.15 PIK47548.1 - 0.14 12.8 0.5 0.55 10.9 0.5 2.0 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Adenyl_cycl_N PF12633.7 PIK47548.1 - 1.3 8.9 8.5 3 7.7 8.5 1.7 1 0 0 1 1 1 0 Adenylate cyclase NT domain Aldo_ket_red PF00248.21 PIK47549.1 - 3.1e-20 72.6 0.0 3.1e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CC2-LZ PF16516.5 PIK47550.1 - 0.017 15.5 0.1 0.035 14.5 0.1 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1759 PF03564.15 PIK47550.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) RVT_1 PF00078.27 PIK47551.1 - 8.8e-35 120.2 0.0 1.1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) fn3 PF00041.21 PIK47552.1 - 1.8e-11 44.2 2.5 2.5e-05 24.6 0.0 3.2 3 0 0 3 3 3 3 Fibronectin type III domain Interfer-bind PF09294.10 PIK47552.1 - 0.014 15.7 0.0 2.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III IL17R_fnIII_D2 PF16578.5 PIK47552.1 - 0.015 15.8 0.7 2.2 8.9 0.1 2.9 2 2 1 3 3 3 0 Interleukin 17 receptor D 7tm_2 PF00002.24 PIK47553.1 - 2.4e-35 122.0 11.5 3.2e-35 121.6 11.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Plasmod_dom_1 PF09715.10 PIK47553.1 - 0.54 10.4 3.7 0.58 10.3 0.7 2.5 2 1 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) DUF3278 PF11683.8 PIK47553.1 - 1.1 9.4 6.3 0.18 11.9 0.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3278) SBF2 PF12335.8 PIK47554.1 - 9.4e-83 277.3 0.3 2e-82 276.3 0.3 1.6 1 0 0 1 1 1 1 Myotubularin protein DENN PF02141.21 PIK47554.1 - 1.1e-50 172.2 0.1 1.1e-50 172.2 0.1 2.7 3 0 0 3 3 3 1 DENN (AEX-3) domain GRAM PF02893.20 PIK47554.1 - 8.4e-14 51.4 0.0 2.2e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 GRAM domain uDENN PF03456.18 PIK47554.1 - 1e-13 51.8 0.1 3.3e-13 50.2 0.1 2.0 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 PIK47554.1 - 0.0019 18.1 0.0 0.0049 16.8 0.0 1.8 1 0 0 1 1 1 1 dDENN domain DUF1774 PF08611.10 PIK47554.1 - 0.031 14.6 0.9 0.081 13.3 0.9 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) Myotub-related PF06602.14 PIK47555.1 - 9.1e-68 228.8 1.7 1.6e-67 227.9 1.7 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain PH PF00169.29 PIK47555.1 - 7.6e-16 58.5 0.4 7.6e-16 58.5 0.4 2.3 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 PIK47555.1 - 1.6e-12 47.1 3.7 1.6e-12 47.1 3.7 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_8 PF15409.6 PIK47555.1 - 8.6e-09 35.6 0.4 3e-08 33.8 0.4 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 PIK47555.1 - 5.8e-07 29.9 4.8 8.9e-06 26.1 4.8 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 PIK47555.1 - 3.1e-06 27.2 0.7 1.1e-05 25.5 0.1 2.2 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 PIK47555.1 - 0.012 15.9 0.2 0.39 11.1 0.0 2.6 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_13 PF16652.5 PIK47555.1 - 0.18 11.6 1.7 0.25 11.1 0.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain NACHT PF05729.12 PIK47556.1 - 7.1e-06 26.0 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK47556.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF4723 PF15851.5 PIK47556.1 - 0.021 14.9 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) AAA_22 PF13401.6 PIK47556.1 - 0.079 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3802 PF12290.8 PIK47557.1 - 0.21 12.1 4.0 10 6.7 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3802) zf-Di19 PF05605.12 PIK47557.1 - 1.3 9.3 8.2 8 6.9 0.3 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF3802 PF12290.8 PIK47558.1 - 0.22 12.1 9.2 4.1 8.0 2.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3802) zf-Di19 PF05605.12 PIK47558.1 - 1.2 9.5 5.9 15 6.0 0.3 3.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ThiS PF02597.20 PIK47558.1 - 1.6 9.4 10.2 4.4e+02 1.6 7.1 4.5 2 1 0 2 2 2 0 ThiS family PAAR_motif PF05488.13 PIK47558.1 - 3.4 7.9 4.9 55 4.0 2.4 3.1 1 1 1 2 2 2 0 PAAR motif MULE PF10551.9 PIK47559.1 - 0.0045 17.4 0.6 0.0068 16.8 0.6 1.3 1 0 0 1 1 1 1 MULE transposase domain YqeY PF09424.10 PIK47560.1 - 0.17 12.0 1.4 0.25 11.4 1.4 1.2 1 0 0 1 1 1 0 Yqey-like protein 2-oxoacid_dh PF00198.23 PIK47561.1 - 1.6e-71 240.4 0.0 2.1e-71 240.0 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 PIK47561.1 - 2.6e-16 59.2 0.0 7.5e-16 57.7 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 PIK47561.1 - 1.1e-07 32.1 0.5 3e-07 30.7 0.1 2.0 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 PIK47561.1 - 0.0088 15.8 0.0 0.054 13.3 0.0 2.4 2 1 0 2 2 2 1 Biotin-lipoyl like ATP-gua_Ptrans PF00217.19 PIK47561.1 - 0.05 13.1 0.4 0.51 9.8 0.0 2.1 1 1 1 2 2 2 0 ATP:guanido phosphotransferase, C-terminal catalytic domain UDPGT PF00201.18 PIK47562.1 - 0.0001 21.3 0.0 0.00012 21.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DUF4715 PF15835.5 PIK47562.1 - 0.031 14.4 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) Integrase_H2C2 PF17921.1 PIK47564.1 - 1.1e-21 76.7 0.3 2e-21 75.9 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK47564.1 - 1.3e-18 67.3 0.0 2.7e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK47564.1 - 4.5e-07 30.0 0.0 9.3e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK47564.1 - 0.00069 19.4 0.4 0.017 14.9 0.0 2.9 3 0 0 3 3 3 1 Integrase core domain ATG11 PF10377.9 PIK47564.1 - 0.0032 17.5 0.0 0.0065 16.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 11 MLVIN_C PF18697.1 PIK47564.1 - 0.04 14.0 0.0 0.088 12.9 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_1 PF00078.27 PIK47565.1 - 9.7e-24 84.1 0.0 1.4e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK47565.1 - 2.2e-17 62.9 0.0 4e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47565.1 - 3.5e-05 24.0 0.0 6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Fibrinogen_C PF00147.18 PIK47566.1 - 1.7e-56 191.5 9.1 2.1e-56 191.2 9.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Mucin2_WxxW PF13330.6 PIK47567.1 - 4.5e-13 49.8 4.2 9.4e-13 48.8 4.2 1.6 1 0 0 1 1 1 1 Mucin-2 protein WxxW repeating region Laminin_G_3 PF13385.6 PIK47567.1 - 2.8e-12 47.0 0.0 4.9e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_transf_54 PF04666.13 PIK47568.1 - 2e-121 404.4 0.0 2.7e-121 403.9 0.0 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region GOLGA2L5 PF15070.6 PIK47568.1 - 0.062 12.0 0.1 0.094 11.4 0.1 1.2 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 FAM176 PF14851.6 PIK47569.1 - 0.063 12.9 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 FAM176 family ODV-E18 PF10717.9 PIK47569.1 - 0.15 12.0 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF4282 PF14110.6 PIK47569.1 - 0.15 12.8 0.2 0.27 12.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) Cad PF03596.13 PIK47569.1 - 0.18 11.6 0.0 0.24 11.3 0.0 1.1 1 0 0 1 1 1 0 Cadmium resistance transporter Calreticulin PF00262.18 PIK47570.1 - 1.8e-119 398.9 24.6 9e-119 396.6 24.6 1.8 1 1 0 1 1 1 1 Calreticulin family zf-AN1 PF01428.16 PIK47571.1 - 7e-17 61.3 37.9 2.4e-11 43.6 11.4 3.8 3 1 1 4 4 4 3 AN1-like Zinc finger UIM PF02809.20 PIK47571.1 - 0.034 14.1 3.7 0.034 14.1 3.7 3.4 3 1 0 3 3 3 0 Ubiquitin interaction motif CCDC50_N PF15295.6 PIK47571.1 - 0.11 12.6 4.6 0.27 11.4 4.6 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Transformer PF06495.11 PIK47571.1 - 6.8 6.8 12.6 0.66 10.0 4.4 2.2 2 0 0 2 2 2 0 Fruit fly transformer protein TPR_11 PF13414.6 PIK47572.1 - 0.0012 18.5 0.1 0.021 14.5 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_17 PF13431.6 PIK47572.1 - 0.022 15.1 0.0 0.066 13.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK47572.1 - 0.44 10.5 0.1 0.44 10.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK47572.1 - 0.98 10.0 4.3 0.7 10.4 0.1 2.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK47572.1 - 1.4 9.2 4.7 6.2 7.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RVT_1 PF00078.27 PIK47573.1 - 9.3e-09 35.1 0.0 1.5e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1758 PF05585.12 PIK47573.1 - 6.8e-06 26.0 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 PIK47573.1 - 0.00063 20.3 0.0 0.0022 18.6 0.0 1.9 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK47573.1 - 0.031 14.8 0.0 0.18 12.4 0.0 2.3 2 1 1 3 3 3 0 gag-polyprotein putative aspartyl protease TPR_17 PF13431.6 PIK47575.1 - 0.00012 22.2 0.4 0.0079 16.5 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK47575.1 - 0.00016 21.2 0.3 0.0026 17.4 0.0 3.0 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 PIK47575.1 - 0.00092 19.2 8.6 6.1 7.3 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK47575.1 - 0.0019 18.6 1.6 0.019 15.4 0.2 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK47575.1 - 0.0065 16.3 7.9 0.39 10.6 0.1 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK47575.1 - 0.019 15.0 7.9 5.5 7.4 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK47575.1 - 0.031 15.1 0.8 71 4.6 0.0 4.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 PIK47575.1 - 0.054 13.8 0.3 2.9 8.3 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK47575.1 - 0.083 13.0 0.1 9.6 6.5 0.1 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RNase_PH PF01138.21 PIK47576.1 - 2.9e-24 86.0 0.0 1e-23 84.3 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK47576.1 - 4.7e-11 42.6 0.0 8.9e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 4HBT_2 PF13279.6 PIK47576.1 - 0.025 15.1 0.0 0.032 14.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily DUF5119 PF17145.4 PIK47577.1 - 0.04 13.9 1.0 0.087 12.8 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5119) HrpB7 PF09486.10 PIK47577.1 - 0.35 11.2 24.5 0.047 14.1 7.6 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Spt20 PF12090.8 PIK47578.1 - 8.4e-29 100.8 0.6 9.7e-15 54.8 0.1 4.0 2 2 1 3 3 3 2 Spt20 family Pirin PF02678.16 PIK47579.1 - 1.9e-14 53.5 0.0 2.3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Pirin Cast PF10174.9 PIK47580.1 - 1.1e-111 374.5 116.2 8.3e-110 368.2 116.2 2.0 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Fez1 PF06818.15 PIK47580.1 - 1.5e-05 25.6 108.2 0.015 15.7 10.7 5.2 1 1 4 5 5 5 4 Fez1 HOOK PF05622.12 PIK47580.1 - 0.00046 18.5 113.3 0.001 17.3 31.7 4.0 1 1 3 4 4 4 2 HOOK protein Fib_alpha PF08702.10 PIK47580.1 - 0.0093 16.2 11.1 0.0093 16.2 11.1 5.9 2 2 4 6 6 6 2 Fibrinogen alpha/beta chain family ERM PF00769.19 PIK47580.1 - 1.4 8.7 119.3 0.12 12.1 19.8 4.3 1 1 3 4 4 4 0 Ezrin/radixin/moesin family ATG16 PF08614.11 PIK47580.1 - 1.9 8.7 122.7 2.6 8.2 11.1 6.8 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 PIK47580.1 - 2.8 7.2 115.3 0.061 12.7 44.6 5.1 1 1 4 5 5 5 0 Tropomyosin DUF4407 PF14362.6 PIK47580.1 - 4.9 6.4 90.1 0.024 14.0 14.9 5.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4407) NAM-associated PF14303.6 PIK47581.1 - 5 7.8 10.5 9.9 6.8 10.5 1.5 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DDE_1 PF03184.19 PIK47582.1 - 5.6e-19 68.5 1.3 1.5e-18 67.0 0.1 2.3 3 0 0 3 3 3 1 DDE superfamily endonuclease PHD PF00628.29 PIK47582.1 - 2.4e-08 33.7 11.5 4.7e-08 32.8 11.5 1.5 1 0 0 1 1 1 1 PHD-finger DDE_3 PF13358.6 PIK47582.1 - 6.5e-07 29.2 0.0 0.0017 18.1 0.0 2.7 2 0 0 2 2 2 2 DDE superfamily endonuclease HTH_psq PF05225.16 PIK47582.1 - 1.1e-05 25.0 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 PIK47582.1 - 9.6e-05 22.3 0.0 0.00022 21.2 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain C1_1 PF00130.22 PIK47582.1 - 0.0014 18.4 1.6 0.0014 18.4 1.6 2.4 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CENP-B_N PF04218.13 PIK47582.1 - 0.021 14.5 0.2 0.062 12.9 0.0 1.8 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Prok-RING_1 PF14446.6 PIK47582.1 - 0.026 14.4 1.7 0.05 13.5 1.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zf_RING PF16744.5 PIK47582.1 - 0.35 11.0 7.6 0.87 9.7 7.6 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_4 PF16866.5 PIK47582.1 - 2.5 8.2 10.8 8 6.6 10.8 1.9 1 0 0 1 1 1 0 PHD-finger Pkinase_Tyr PF07714.17 PIK47583.1 - 2.2e-17 63.2 0.0 3.4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47583.1 - 4.7e-13 49.1 0.0 7.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain UBA_2 PF08587.11 PIK47584.1 - 0.2 11.8 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DUF5423 PF17461.2 PIK47585.1 - 0.42 9.4 3.6 0.52 9.1 3.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Y_phosphatase PF00102.27 PIK47586.1 - 7.9e-73 244.9 0.1 1.1e-72 244.5 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK47586.1 - 6.4e-06 26.3 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK47586.1 - 0.00042 20.5 0.0 0.0012 19.0 0.0 1.8 1 1 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 PIK47586.1 - 0.0008 19.2 0.1 0.0021 17.9 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Ribosomal_L29 PF00831.23 PIK47586.1 - 0.12 12.4 0.2 0.27 11.2 0.2 1.6 1 0 0 1 1 1 0 Ribosomal L29 protein Serglycin PF04360.12 PIK47586.1 - 4.2 7.3 6.9 3.3 7.6 3.5 2.2 2 0 0 2 2 2 0 Serglycin 7tm_1 PF00001.21 PIK47587.1 - 5.4e-33 114.4 2.4 7.4e-33 114.0 2.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK47587.1 - 8.1e-08 32.0 11.4 7.3e-05 22.3 6.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK47587.1 - 6e-05 22.8 11.2 6e-05 22.8 11.2 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1980 PF09323.10 PIK47587.1 - 0.007 16.3 2.4 1.3 8.9 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1980) FYVE PF01363.21 PIK47588.1 - 2.5e-17 62.8 10.3 4.5e-17 62.0 10.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger RhoGEF PF00621.20 PIK47588.1 - 9.6e-16 58.5 0.1 2.6e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 PIK47588.1 - 8.6e-12 45.5 0.3 1.5e-05 25.4 0.0 2.8 3 0 0 3 3 3 2 PH domain FYVE_2 PF02318.16 PIK47588.1 - 6.7e-05 23.1 6.9 0.00017 21.8 6.9 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 PIK47588.1 - 0.00046 20.0 0.9 0.76 9.6 0.0 2.9 2 1 1 3 3 3 2 Pleckstrin homology domain PH_6 PF15406.6 PIK47588.1 - 0.012 15.9 0.1 0.046 14.0 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 PIK47588.1 - 0.017 15.1 0.1 0.052 13.5 0.1 1.8 1 1 0 1 1 1 0 PH domain ADH_N PF08240.12 PIK47589.1 - 1.1e-12 47.8 0.0 2.2e-12 46.8 0.0 1.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Tim17 PF02466.19 PIK47590.1 - 8.4e-28 97.0 4.3 1.1e-27 96.6 4.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CENP-K PF11802.8 PIK47591.1 - 1.4e-38 133.0 11.7 1.6e-38 132.8 11.7 1.0 1 0 0 1 1 1 1 Centromere-associated protein K DivIVA PF05103.13 PIK47591.1 - 0.0039 17.3 6.9 0.0039 17.3 6.9 1.6 2 0 0 2 2 1 1 DivIVA protein SKA1 PF07160.12 PIK47591.1 - 0.0044 16.9 6.8 0.0065 16.4 6.8 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 GLYCAM-1 PF05242.11 PIK47591.1 - 0.013 15.6 6.0 0.017 15.2 5.5 1.4 1 1 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) DUF1664 PF07889.12 PIK47591.1 - 0.028 14.5 9.9 0.068 13.2 9.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 PIK47591.1 - 0.031 11.8 9.3 0.038 11.5 9.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DNA_Packaging PF11053.8 PIK47591.1 - 0.053 13.4 1.3 0.085 12.7 1.3 1.3 1 0 0 1 1 1 0 Terminase DNA packaging enzyme UPF0242 PF06785.11 PIK47591.1 - 0.078 13.1 14.6 0.12 12.5 14.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-Q PF13094.6 PIK47591.1 - 0.082 13.1 12.8 0.056 13.7 9.4 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Muted PF14942.6 PIK47591.1 - 0.13 12.6 12.5 0.21 11.9 12.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF2570 PF10828.8 PIK47591.1 - 0.3 10.9 8.2 0.54 10.1 8.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Mst1_SARAH PF11629.8 PIK47591.1 - 0.31 11.2 3.7 2.7 8.2 0.1 2.7 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Fib_alpha PF08702.10 PIK47591.1 - 0.37 11.0 7.9 0.92 9.7 7.9 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 PIK47591.1 - 0.63 9.6 7.0 0.78 9.3 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nas2_N PF18265.1 PIK47591.1 - 0.76 9.7 7.6 13 5.8 0.0 3.4 2 1 1 3 3 3 0 Nas2 N_terminal domain ApoO PF09769.9 PIK47591.1 - 0.97 9.4 4.6 4.2 7.4 1.5 2.1 1 1 1 2 2 2 0 Apolipoprotein O Prefoldin_2 PF01920.20 PIK47591.1 - 1.5 8.8 17.5 40 4.2 9.5 2.7 1 1 1 2 2 2 0 Prefoldin subunit FapA PF03961.13 PIK47591.1 - 3.1 6.3 6.6 4.2 5.9 6.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Lzipper-MIP1 PF14389.6 PIK47591.1 - 3.4 8.0 18.5 0.29 11.5 6.4 3.3 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 MotA_ExbB PF01618.16 PIK47591.1 - 7.6 6.3 6.8 5.1 6.9 0.2 2.5 1 1 0 2 2 2 0 MotA/TolQ/ExbB proton channel family betaPIX_CC PF16523.5 PIK47591.1 - 9.4 6.1 12.7 3 7.7 4.7 2.6 1 1 1 2 2 2 0 betaPIX coiled coil DHR-2 PF06920.13 PIK47593.1 - 0.00019 20.3 0.2 0.00023 19.9 0.2 1.1 1 0 0 1 1 1 1 Dock homology region 2 Ofd1_CTDD PF10637.9 PIK47593.1 - 0.069 12.5 0.6 0.089 12.1 0.6 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term DHR-2 PF06920.13 PIK47594.1 - 1.9e-17 63.1 3.9 3.6e-14 52.3 0.4 3.3 1 1 2 3 3 3 3 Dock homology region 2 U3_assoc_6 PF08640.11 PIK47594.1 - 0.028 14.5 2.6 0.35 11.0 0.5 2.9 2 1 1 3 3 3 0 U3 small nucleolar RNA-associated protein 6 DOCK-C2 PF14429.6 PIK47595.1 - 2.6e-33 115.5 0.1 4.5e-33 114.7 0.1 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 PIK47595.1 - 8.2e-21 74.3 0.5 2.6e-19 69.4 0.0 3.4 3 1 0 3 3 3 1 DOCK N-terminus DNA_pol3_a_NII PF11490.8 PIK47595.1 - 0.087 12.7 0.1 0.37 10.7 0.1 2.1 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II RIH_assoc PF08454.11 PIK47595.1 - 0.15 11.9 8.2 0.39 10.6 0.0 4.2 3 2 1 4 4 4 0 RyR and IP3R Homology associated DOCK_N PF16172.5 PIK47596.1 - 3.4e-10 39.4 0.1 4.8e-10 38.9 0.1 1.1 1 0 0 1 1 1 1 DOCK N-terminus SH3_2 PF07653.17 PIK47596.1 - 0.00035 20.2 0.0 0.00074 19.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK47596.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain AAA_11 PF13086.6 PIK47597.1 - 2.3e-27 96.4 0.1 1.9e-13 50.8 0.0 2.6 2 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 PIK47597.1 - 1.5e-11 44.4 0.0 3.6e-11 43.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK47597.1 - 4.6e-09 36.8 0.0 9.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK47597.1 - 0.003 17.6 0.0 0.0074 16.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-met PF12874.7 PIK47597.1 - 0.003 17.9 0.4 0.0073 16.7 0.4 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AAA_16 PF13191.6 PIK47597.1 - 0.004 17.6 0.0 0.008 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain zf-C2H2_jaz PF12171.8 PIK47597.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding UvrD-helicase PF00580.21 PIK47597.1 - 0.0074 15.8 0.3 0.73 9.3 0.0 3.2 2 1 2 4 4 4 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 PIK47597.1 - 0.012 15.9 0.0 0.076 13.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK47597.1 - 0.013 15.1 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 PIK47597.1 - 0.018 15.4 0.0 0.039 14.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 PIK47598.1 - 1.6e-25 89.9 0.0 2.8e-20 72.8 0.1 2.2 1 1 1 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 PIK47598.1 - 0.19 11.6 0.2 1.9 8.4 0.2 2.2 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Cytochrom_B561 PF03188.16 PIK47599.1 - 7.2e-31 107.2 8.5 7.2e-31 107.2 8.5 1.9 1 1 1 2 2 2 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 PIK47599.1 - 0.00086 19.5 12.2 0.023 14.8 1.9 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF4079) DUF3087 PF11286.8 PIK47599.1 - 0.04 13.4 0.9 0.04 13.4 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) CbiM PF01891.16 PIK47599.1 - 0.2 11.5 13.0 0.57 10.0 0.9 3.0 1 1 2 3 3 3 0 Cobalt uptake substrate-specific transmembrane region TctA PF01970.16 PIK47599.1 - 0.44 9.2 12.0 0.5 9.0 4.5 2.1 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctA family DUF4131 PF13567.6 PIK47599.1 - 0.67 9.6 5.8 2.6 7.7 0.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Ferric_reduct PF01794.19 PIK47599.1 - 2.5 8.2 17.0 0.065 13.4 8.9 2.1 1 1 2 3 3 3 0 Ferric reductase like transmembrane component DUF2231 PF09990.9 PIK47599.1 - 3.3 8.2 12.8 2.4 8.6 0.5 3.0 1 1 1 3 3 3 0 Predicted membrane protein (DUF2231) NPR2 PF06218.11 PIK47600.1 - 1.6e-66 224.9 3.5 1.1e-62 212.3 6.2 2.9 1 1 1 2 2 2 2 Nitrogen permease regulator 2 Ribosomal_S25 PF03297.15 PIK47600.1 - 0.096 12.9 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 S25 ribosomal protein DED PF01335.21 PIK47601.1 - 0.0096 16.2 0.6 0.016 15.5 0.6 1.4 1 0 0 1 1 1 1 Death effector domain GAS PF13851.6 PIK47602.1 - 4.9e-06 26.0 55.7 0.001 18.5 43.0 2.7 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK47602.1 - 0.00051 19.9 60.2 0.01 15.7 45.3 2.2 1 1 1 2 2 2 2 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK47602.1 - 0.0084 16.6 65.2 0.013 16.0 21.0 3.2 1 1 1 2 2 2 1 Apg6 coiled-coil region Cep57_MT_bd PF06657.13 PIK47602.1 - 0.022 15.2 40.7 0.028 14.8 7.2 4.5 1 1 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 WEMBL PF05701.11 PIK47602.1 - 0.031 13.0 40.6 0.04 12.6 40.6 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light CALCOCO1 PF07888.11 PIK47602.1 - 0.036 12.9 46.6 0.051 12.4 46.6 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Lebercilin PF15619.6 PIK47602.1 - 0.078 12.6 56.5 0.024 14.3 41.5 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4806 PF16064.5 PIK47602.1 - 0.13 12.6 14.1 0.32 11.3 1.9 4.1 2 1 2 4 4 4 0 Domain of unknown function (DUF4806) HBM PF16591.5 PIK47602.1 - 0.14 11.6 35.6 0.51 9.7 35.6 2.0 1 1 0 1 1 1 0 Helical bimodular sensor domain TACC_C PF05010.14 PIK47602.1 - 0.2 11.5 45.2 0.17 11.6 17.9 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Caldesmon PF02029.15 PIK47602.1 - 0.22 10.2 37.0 0.35 9.6 37.0 1.3 1 0 0 1 1 1 0 Caldesmon DUF4472 PF14739.6 PIK47602.1 - 0.23 12.2 49.2 2.9 8.7 11.0 4.3 1 1 4 5 5 5 0 Domain of unknown function (DUF4472) Spc7 PF08317.11 PIK47602.1 - 0.27 10.1 54.1 0.15 10.9 25.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Rab5-bind PF09311.11 PIK47602.1 - 0.31 10.4 45.7 0.57 9.5 17.8 2.1 1 1 1 2 2 2 0 Rabaptin-like protein ATG16 PF08614.11 PIK47602.1 - 0.33 11.1 60.3 1.4 9.1 26.2 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SKA2 PF16740.5 PIK47602.1 - 0.4 10.5 38.2 0.18 11.6 5.4 3.9 1 1 3 4 4 4 0 Spindle and kinetochore-associated protein 2 HIP1_clath_bdg PF16515.5 PIK47602.1 - 0.92 10.2 57.0 1.5 9.5 17.8 3.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PilA4 PF18682.1 PIK47602.1 - 0.97 9.9 5.3 6.8 7.2 0.4 3.6 2 1 1 4 4 4 0 Pilin A4 KASH_CCD PF14662.6 PIK47602.1 - 0.98 9.2 54.2 0.47 10.2 25.3 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH FmiP_Thoc5 PF09766.9 PIK47602.1 - 1.2 8.4 45.2 0.47 9.7 22.6 2.2 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 COG2 PF06148.11 PIK47602.1 - 1.5 9.0 31.0 0.8 9.8 9.4 3.4 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 SCO1-SenC PF02630.14 PIK47602.1 - 1.5 8.7 8.8 1.3 8.9 1.1 2.5 1 1 1 2 2 2 0 SCO1/SenC EzrA PF06160.12 PIK47602.1 - 3.2 5.8 39.7 6.6 4.8 39.8 1.4 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Fez1 PF06818.15 PIK47602.1 - 3.8 7.9 50.9 1.5 9.2 23.3 2.3 1 1 1 2 2 2 0 Fez1 CREPT PF16566.5 PIK47602.1 - 4.2 7.5 37.0 3.6 7.8 16.2 2.8 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TPD52 PF04201.15 PIK47602.1 - 5.6 6.5 39.4 0.13 11.8 7.4 3.6 1 1 2 3 3 3 0 Tumour protein D52 family PI3K_P85_iSH2 PF16454.5 PIK47602.1 - 6 6.4 44.0 3.9 7.0 11.1 3.6 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4407 PF14362.6 PIK47602.1 - 6.7 6.0 47.5 1.1 8.5 21.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) FapA PF03961.13 PIK47602.1 - 7.5 5.0 39.5 5 5.6 11.8 2.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A T3SSipB PF16535.5 PIK47602.1 - 7.8 7.0 38.5 0.58 10.6 7.5 3.3 1 1 2 3 3 3 0 Type III cell invasion protein SipB ZU5 PF00791.20 PIK47603.1 - 3.6e-11 43.3 0.0 8.8e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain ZU5 PF00791.20 PIK47604.1 - 0.0042 17.4 0.5 0.012 16.0 0.0 2.0 3 0 0 3 3 3 1 ZU5 domain ERM PF00769.19 PIK47605.1 - 5.2e-05 23.2 28.3 7e-05 22.8 28.3 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family CALCOCO1 PF07888.11 PIK47605.1 - 0.00087 18.3 23.0 0.0011 18.0 23.0 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.11 PIK47605.1 - 0.0012 19.1 28.7 0.0014 18.9 28.7 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) GAS PF13851.6 PIK47605.1 - 0.0013 18.1 30.2 0.0028 17.0 25.5 2.4 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding HMMR_N PF15905.5 PIK47605.1 - 0.0033 16.9 24.0 0.004 16.7 24.0 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 PIK47605.1 - 0.0066 16.1 24.7 0.0086 15.7 24.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein FPP PF05911.11 PIK47605.1 - 0.008 14.4 18.2 0.0095 14.2 18.2 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil APG6_N PF17675.1 PIK47605.1 - 0.012 16.2 36.0 0.014 15.9 28.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region TTKRSYEDQ PF10212.9 PIK47605.1 - 0.012 14.6 14.6 0.23 10.4 5.2 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF812 PF05667.11 PIK47605.1 - 0.019 13.8 19.4 0.023 13.6 19.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FmiP_Thoc5 PF09766.9 PIK47605.1 - 0.028 13.7 18.4 0.035 13.4 18.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 TACC_C PF05010.14 PIK47605.1 - 0.037 13.8 22.5 0.11 12.3 22.5 1.6 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ApoO PF09769.9 PIK47605.1 - 0.042 13.8 9.5 0.6 10.1 0.7 2.3 1 1 1 2 2 2 0 Apolipoprotein O Spc7 PF08317.11 PIK47605.1 - 0.07 12.0 25.5 0.086 11.7 25.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 PIK47605.1 - 0.075 10.6 25.2 0.085 10.4 25.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 PIK47605.1 - 0.077 13.0 12.6 0.12 12.4 5.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SKA2 PF16740.5 PIK47605.1 - 0.077 12.8 15.0 0.25 11.1 6.0 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 DegS PF05384.11 PIK47605.1 - 0.082 12.4 18.7 0.066 12.7 1.2 2.4 1 1 1 2 2 2 0 Sensor protein DegS DUF4472 PF14739.6 PIK47605.1 - 0.15 12.8 23.1 0.49 11.2 11.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Lebercilin PF15619.6 PIK47605.1 - 0.15 11.7 29.9 0.042 13.5 15.5 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 PIK47605.1 - 0.2 12.3 30.9 0.049 14.2 18.6 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-F_leu_zip PF10473.9 PIK47605.1 - 0.21 11.6 30.1 3.3 7.7 10.9 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T3SSipB PF16535.5 PIK47605.1 - 0.23 12.0 14.6 1 9.8 14.6 2.1 1 1 0 1 1 1 0 Type III cell invasion protein SipB Fez1 PF06818.15 PIK47605.1 - 0.23 11.9 27.3 0.51 10.8 27.3 1.5 1 1 0 1 1 1 0 Fez1 Nsp1_C PF05064.13 PIK47605.1 - 0.25 11.2 17.3 0.053 13.3 10.2 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region PI3K_P85_iSH2 PF16454.5 PIK47605.1 - 0.28 10.8 23.9 0.51 9.9 10.6 2.8 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Syntaxin-6_N PF09177.11 PIK47605.1 - 0.32 11.6 19.8 1.3 9.6 5.6 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4164 PF13747.6 PIK47605.1 - 0.32 11.3 20.9 0.69 10.2 9.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Golgin_A5 PF09787.9 PIK47605.1 - 0.33 10.4 21.0 0.51 9.8 21.0 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 FliT PF05400.13 PIK47605.1 - 0.42 11.5 20.2 8.6 7.3 11.1 2.7 1 1 1 2 2 2 0 Flagellar protein FliT DUF3450 PF11932.8 PIK47605.1 - 0.72 9.1 22.7 0.72 9.1 21.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Oberon_cc PF16312.5 PIK47605.1 - 0.89 9.5 21.5 2.2e+03 -1.5 21.5 3.0 1 1 0 1 1 1 0 Coiled-coil region of Oberon Cep57_MT_bd PF06657.13 PIK47605.1 - 0.95 10.0 19.0 0.36 11.3 5.2 3.0 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 LXG PF04740.12 PIK47605.1 - 1 9.1 18.5 2.6 7.7 3.5 2.2 1 1 1 2 2 2 0 LXG domain of WXG superfamily Bacillus_HBL PF05791.11 PIK47605.1 - 1.3 8.8 15.2 0.71 9.7 7.2 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FlgN PF05130.12 PIK47605.1 - 1.3 9.5 23.0 7.1 7.1 18.4 2.2 1 1 1 2 2 2 0 FlgN protein DUF4726 PF15855.5 PIK47605.1 - 1.5 9.1 8.8 7.4 6.9 0.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4726) Exonuc_VII_L PF02601.15 PIK47605.1 - 1.7 8.2 14.6 2.5 7.6 14.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2072 PF09845.9 PIK47605.1 - 2.1 8.6 11.2 0.27 11.5 2.6 2.2 1 1 1 2 2 1 0 Zn-ribbon containing protein DUF4192 PF13830.6 PIK47605.1 - 2.1 8.3 5.0 2.3 8.2 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) DUF3128 PF11326.8 PIK47605.1 - 2.2 8.7 10.3 0.83 10.1 0.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) LMBR1 PF04791.16 PIK47605.1 - 3 6.7 13.2 3.6 6.4 13.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Metal_resist PF13801.6 PIK47605.1 - 3 8.0 13.3 0.65 10.2 2.0 2.3 1 1 1 2 2 2 0 Heavy-metal resistance CREPT PF16566.5 PIK47605.1 - 3.3 7.9 20.0 14 5.8 7.4 2.2 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Fib_alpha PF08702.10 PIK47605.1 - 3.3 7.9 16.7 1.9 8.7 10.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF2400 PF09674.10 PIK47605.1 - 3.4 7.6 8.1 7.5 6.5 8.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) FapA PF03961.13 PIK47605.1 - 4.8 5.7 21.4 4.7 5.7 7.0 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4407 PF14362.6 PIK47605.1 - 5 6.4 18.3 6.4 6.0 18.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 PIK47605.1 - 5.3 7.1 28.7 13 5.9 28.7 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 PIK47605.1 - 5.7 6.7 20.0 12 5.6 19.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF2252 PF10009.9 PIK47605.1 - 6.4 5.7 14.9 4.7 6.2 2.8 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) CENP-Q PF13094.6 PIK47605.1 - 6.7 6.9 25.9 9.4 6.4 25.9 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit KfrA_N PF11740.8 PIK47605.1 - 7.4 7.3 23.3 0.65 10.7 5.0 3.0 1 1 1 2 2 1 0 Plasmid replication region DNA-binding N-term bZIP_1 PF00170.21 PIK47605.1 - 8.3 6.6 22.2 1.1 9.4 2.4 3.3 1 1 2 3 3 3 0 bZIP transcription factor Sec20 PF03908.13 PIK47605.1 - 8.3 6.4 11.7 7.7 6.5 5.0 3.1 1 1 3 4 4 4 0 Sec20 Neur_chan_memb PF02932.16 PIK47605.1 - 8.8 6.3 7.2 11 6.0 7.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 PIK47605.1 - 8.8 4.1 18.2 14 3.4 18.2 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Helo_like_N PF17111.5 PIK47605.1 - 9.1 5.6 19.1 4.6 6.6 1.4 2.3 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins Pkinase PF00069.25 PIK47606.1 - 4.9e-28 98.2 0.0 7.7e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47606.1 - 1.1e-12 47.8 0.0 7.8e-12 45.0 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK47606.1 - 4.9e-05 23.4 0.0 0.00013 22.0 0.0 1.6 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK47606.1 - 0.0098 15.5 0.0 0.065 12.8 0.0 2.1 2 1 1 3 3 3 1 Choline/ethanolamine kinase Kdo PF06293.14 PIK47606.1 - 0.031 13.6 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ADH_N PF08240.12 PIK47606.1 - 0.08 12.8 0.0 5.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain DED PF01335.21 PIK47608.1 - 0.055 13.8 0.1 0.055 13.8 0.1 1.8 2 0 0 2 2 2 0 Death effector domain Caldesmon PF02029.15 PIK47609.1 - 0.0031 16.4 20.9 0.0041 16.0 20.9 1.1 1 0 0 1 1 1 1 Caldesmon CALCOCO1 PF07888.11 PIK47609.1 - 0.0051 15.7 25.5 0.0063 15.4 25.5 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 PIK47609.1 - 0.0055 16.1 22.3 0.0055 16.1 22.3 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.19 PIK47609.1 - 0.0079 14.2 7.6 0.0087 14.0 7.6 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Sipho_Gp157 PF05565.11 PIK47609.1 - 0.015 15.3 19.3 0.22 11.5 9.4 2.5 1 1 1 2 2 2 0 Siphovirus Gp157 ERM PF00769.19 PIK47609.1 - 0.076 12.8 40.6 0.19 11.5 40.7 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 PIK47609.1 - 0.22 11.0 29.5 0.33 10.4 29.5 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Beta-lactamase2 PF13354.6 PIK47609.1 - 0.23 11.1 8.4 0.13 11.8 1.5 2.9 1 1 2 3 3 3 0 Beta-lactamase enzyme family PfkB PF00294.24 PIK47609.1 - 0.31 10.3 5.2 1.4 8.1 0.3 2.6 1 1 2 3 3 3 0 pfkB family carbohydrate kinase Peptidase_S46 PF10459.9 PIK47609.1 - 0.37 9.4 14.1 0.47 9.0 14.1 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF4407 PF14362.6 PIK47609.1 - 0.49 9.7 24.6 0.63 9.3 24.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 PIK47609.1 - 0.58 10.7 44.1 0.068 13.7 26.3 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region FmiP_Thoc5 PF09766.9 PIK47609.1 - 0.79 8.9 27.5 0.095 12.0 22.8 1.7 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 T3SSipB PF16535.5 PIK47609.1 - 0.83 10.1 22.2 0.15 12.6 5.4 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB Fumble PF03630.14 PIK47609.1 - 0.84 8.8 6.5 1.1 8.3 6.5 1.1 1 0 0 1 1 1 0 Fumble HMMR_N PF15905.5 PIK47609.1 - 1.1 8.6 33.9 1.9 7.9 33.9 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal COG2 PF06148.11 PIK47609.1 - 1.4 9.0 19.0 1.7 8.7 8.5 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 KASH_CCD PF14662.6 PIK47609.1 - 1.5 8.6 35.8 4.1 7.2 35.8 1.7 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF4806 PF16064.5 PIK47609.1 - 1.5 9.2 6.6 17 5.8 1.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4806) hGDE_central PF14702.6 PIK47609.1 - 1.7 8.3 5.9 2.5 7.7 5.9 1.3 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme DUF4472 PF14739.6 PIK47609.1 - 1.9 9.3 30.7 0.4 11.4 17.8 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DUF1664 PF07889.12 PIK47609.1 - 3 7.9 18.0 2.2 8.4 8.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PilA4 PF18682.1 PIK47609.1 - 3.1 8.2 5.1 8.8 6.8 0.3 3.1 2 1 0 3 3 3 0 Pilin A4 zf-C4H2 PF10146.9 PIK47609.1 - 3.4 7.9 14.6 5.5 7.2 14.6 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein MDM10 PF12519.8 PIK47609.1 - 4.3 6.1 9.8 6 5.6 9.8 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FUSC PF04632.12 PIK47609.1 - 4.5 5.7 10.0 6.1 5.3 10.0 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2868 PF11067.8 PIK47609.1 - 5.6 6.4 10.8 7.6 5.9 10.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Macoilin PF09726.9 PIK47609.1 - 8.3 4.8 19.0 9.2 4.7 19.0 1.1 1 0 0 1 1 1 0 Macoilin family YkuI_C PF10388.9 PIK47609.1 - 9.6 6.0 10.7 4.2 7.2 7.5 1.9 1 1 1 2 2 2 0 EAL-domain associated signalling protein domain Pkinase PF00069.25 PIK47610.1 - 1.6e-13 50.7 0.0 7.9e-13 48.4 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47610.1 - 3.3e-05 23.3 0.0 7.2e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK47610.1 - 0.0011 19.0 0.0 0.0031 17.5 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK47610.1 - 0.0044 16.6 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 PIK47610.1 - 0.2 10.6 0.1 0.31 10.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF948 PF06103.11 PIK47610.1 - 0.42 10.9 5.0 1.2 9.4 0.4 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SCO1-SenC PF02630.14 PIK47610.1 - 1 9.3 4.7 1.1 9.2 0.4 2.2 1 1 1 2 2 2 0 SCO1/SenC MCPsignal PF00015.21 PIK47610.1 - 1 9.2 5.4 1.3 8.8 3.0 2.1 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain HSP70 PF00012.20 PIK47612.1 - 3e-192 640.0 17.3 4.8e-179 596.4 3.6 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK47612.1 - 3.1e-16 59.1 0.2 2.9e-14 52.6 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 PIK47612.1 - 2.7e-05 24.0 0.0 5.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 PIK47612.1 - 0.016 14.5 0.5 0.12 11.6 0.0 2.4 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase StbA PF06406.11 PIK47612.1 - 0.019 14.2 0.1 0.098 11.9 0.0 2.2 2 0 0 2 2 2 0 StbA protein DUF1464 PF07318.12 PIK47612.1 - 0.067 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) FtsA PF14450.6 PIK47612.1 - 0.14 12.6 10.8 4.7 7.7 0.4 4.0 2 2 1 3 3 3 0 Cell division protein FtsA HSP70 PF00012.20 PIK47613.1 - 5.4e-254 843.9 9.1 6.2e-254 843.7 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK47613.1 - 1.2e-16 60.4 0.3 9e-15 54.3 0.1 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 PIK47613.1 - 2.2e-05 24.3 0.0 8.7e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 PIK47613.1 - 0.0034 16.7 0.1 0.019 14.2 0.0 2.3 3 0 0 3 3 3 1 StbA protein DUF1464 PF07318.12 PIK47613.1 - 0.026 13.7 0.0 0.055 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) FtsA PF14450.6 PIK47613.1 - 0.054 13.9 8.3 6.9 7.2 0.4 4.0 3 2 0 3 3 3 0 Cell division protein FtsA CobU PF02283.16 PIK47613.1 - 0.092 12.3 0.8 0.18 11.4 0.8 1.4 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Hydantoinase_A PF01968.18 PIK47613.1 - 0.099 11.9 1.3 0.32 10.2 0.1 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase bZIP_1 PF00170.21 PIK47615.1 - 2.5e-05 24.3 11.5 4.1e-05 23.6 11.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK47615.1 - 0.00048 20.2 10.7 0.00078 19.5 10.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper PCRF PF03462.18 PIK47615.1 - 0.025 14.5 0.7 0.029 14.2 0.7 1.1 1 0 0 1 1 1 0 PCRF domain Jnk-SapK_ap_N PF09744.9 PIK47615.1 - 0.027 14.7 6.1 0.029 14.6 6.1 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HrpJ PF07201.11 PIK47615.1 - 0.06 13.7 4.9 0.08 13.3 4.9 1.1 1 0 0 1 1 1 0 HrpJ-like domain Chromo PF00385.24 PIK47616.1 - 0.075 12.9 0.3 0.12 12.3 0.3 1.5 1 1 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain SET PF00856.28 PIK47617.1 - 0.00026 21.4 0.0 0.00032 21.1 0.0 1.2 1 0 0 1 1 1 1 SET domain C2-set_2 PF08205.12 PIK47618.1 - 1.3e-06 28.4 0.9 0.0055 16.7 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK47618.1 - 1.7e-06 28.3 1.0 0.19 12.1 0.0 4.4 3 1 0 4 4 4 1 Immunoglobulin domain Ig_3 PF13927.6 PIK47618.1 - 0.00011 22.7 4.8 0.13 12.8 0.0 4.5 3 2 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK47618.1 - 0.00073 19.7 0.2 0.014 15.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain NACHT PF05729.12 PIK47618.1 - 0.0017 18.3 0.0 0.0045 16.9 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK47618.1 - 0.0066 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ig PF00047.25 PIK47618.1 - 0.011 15.8 0.3 1.2 9.4 0.0 3.1 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK47618.1 - 0.013 15.6 0.3 5.2 7.2 0.0 3.3 3 1 0 3 3 3 0 Immunoglobulin I-set domain DAP3 PF10236.9 PIK47618.1 - 0.077 12.2 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TMEM154 PF15102.6 PIK47618.1 - 0.079 12.9 0.2 0.19 11.6 0.2 1.6 1 0 0 1 1 1 0 TMEM154 protein family DAG1 PF05454.11 PIK47618.1 - 0.083 12.3 0.3 0.14 11.5 0.3 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) AAA_22 PF13401.6 PIK47618.1 - 0.095 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK47619.1 - 8.4e-09 35.5 0.0 4.2e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 NACHT domain HAGH_C PF16123.5 PIK47619.1 - 0.12 12.8 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus ig PF00047.25 PIK47620.1 - 0.0031 17.6 0.1 0.0072 16.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain NHL PF01436.21 PIK47620.1 - 0.0084 16.1 3.7 4.3 7.6 0.0 4.4 6 0 0 6 6 6 1 NHL repeat Ig_5 PF16681.5 PIK47620.1 - 0.011 16.1 0.2 0.66 10.4 0.1 2.7 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 PIK47620.1 - 0.013 15.7 0.1 0.05 13.8 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK47620.1 - 0.015 15.4 0.1 0.035 14.2 0.1 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain SBBP PF06739.11 PIK47620.1 - 0.027 14.4 0.2 0.077 13.0 0.2 1.7 1 0 0 1 1 1 0 Beta-propeller repeat Ig_6 PF18452.1 PIK47620.1 - 0.13 11.8 0.5 1.1 8.9 0.5 2.3 1 1 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 PIK47620.1 - 0.16 12.3 0.6 0.47 10.8 0.2 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK47620.1 - 0.23 12.1 0.7 0.93 10.1 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK47621.1 - 6.1e-23 81.4 0.0 7.8e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47621.1 - 8.1e-16 58.2 0.0 1e-15 57.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain RVT_1 PF00078.27 PIK47622.1 - 4.1e-22 78.8 0.0 5.4e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK47623.1 - 1.2e-09 38.4 0.0 2.9e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain GPI2 PF06432.11 PIK47623.1 - 0.0026 17.2 0.1 0.0037 16.8 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_25 PF13481.6 PIK47623.1 - 0.0059 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Albumin_I_a PF16720.5 PIK47623.1 - 0.059 13.3 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Albumin I chain a LRR_4 PF12799.7 PIK47623.1 - 0.079 13.4 0.2 0.28 11.7 0.2 2.0 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Peptidase_A17 PF05380.13 PIK47624.1 - 2.3e-12 47.2 0.0 4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase CBAH PF02275.18 PIK47625.1 - 2.7e-22 79.8 0.0 2.3e-21 76.8 0.0 1.9 1 1 1 2 2 2 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 PIK47625.1 - 9.2e-09 35.5 0.1 2.1e-08 34.3 0.1 1.7 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase SNF2_N PF00176.23 PIK47626.1 - 2.5e-60 204.1 0.4 1e-59 202.0 0.1 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 PIK47626.1 - 3.4e-08 33.7 0.0 9.7e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK47626.1 - 3.4e-05 23.7 0.0 4.9e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 PIK47626.1 - 0.00094 18.9 0.0 0.0027 17.4 0.0 1.9 1 1 0 1 1 1 1 SWI2/SNF2 ATPase SLIDE PF09111.10 PIK47627.1 - 2.5e-41 140.3 0.8 2.5e-41 140.3 0.8 2.3 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 PIK47627.1 - 1.8e-30 106.0 2.1 6.8e-30 104.1 0.1 2.8 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 PIK47627.1 - 2.1e-11 44.1 0.0 5.7e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Myb_DNA-binding PF00249.31 PIK47627.1 - 2.1e-10 40.6 0.7 0.00023 21.3 0.0 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK47627.1 - 0.035 14.4 3.5 0.57 10.5 0.1 2.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF5440 PF17509.2 PIK47627.1 - 0.043 13.4 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5440) LisH_2 PF16045.5 PIK47628.1 - 1.6e-14 52.6 0.1 2.8e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 LisH FOP_dimer PF09398.10 PIK47628.1 - 7e-05 23.0 0.5 0.00071 19.8 0.0 2.3 3 0 0 3 3 3 1 FOP N terminal dimerisation domain LisH PF08513.11 PIK47628.1 - 0.0006 19.7 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 LisH Adaptin_binding PF10199.9 PIK47630.1 - 0.61 10.7 12.1 11 6.7 8.5 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 YtxH PF12732.7 PIK47630.1 - 4.6 7.8 4.8 19 5.9 0.2 2.7 2 0 0 2 2 2 0 YtxH-like protein DUF4641 PF15483.6 PIK47632.1 - 0.0055 15.9 15.2 0.009 15.2 0.4 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4641) DUF4317 PF14199.6 PIK47632.1 - 0.01 15.1 7.0 0.015 14.5 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) PBP1_TM PF14812.6 PIK47632.1 - 0.02 15.3 5.8 0.044 14.2 5.8 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 PIK47632.1 - 0.15 10.1 7.6 0.27 9.3 7.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CwfJ_C_1 PF04677.15 PIK47633.1 - 1.4e-39 134.7 0.1 2.3e-39 134.0 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 PIK47633.1 - 1e-31 109.7 0.2 1e-31 109.7 0.2 3.2 4 0 0 4 4 4 1 Protein similar to CwfJ C-terminus 2 Pre-PUA PF17832.1 PIK47634.1 - 4.5e-23 81.7 0.0 7e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 PIK47634.1 - 2.1e-05 24.4 0.0 5.4e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 PUA domain DUF1947 PF09183.10 PIK47634.1 - 0.0014 18.9 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1947) ABC_tran PF00005.27 PIK47635.1 - 6.7e-37 127.1 0.0 1.4e-17 64.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 PIK47635.1 - 1.1e-13 50.8 5.4 3e-13 49.3 5.4 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 PIK47635.1 - 7.9e-10 38.5 1.3 0.0045 16.5 0.3 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 PIK47635.1 - 1.8e-09 37.8 2.8 0.3 10.8 1.4 4.3 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 PIK47635.1 - 2.2e-06 28.1 0.0 0.058 13.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK47635.1 - 3.7e-06 27.4 0.0 0.085 13.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain Fer4 PF00037.27 PIK47635.1 - 9.8e-06 25.2 7.0 9.8e-06 25.2 7.0 2.5 3 0 0 3 3 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 PIK47635.1 - 1.6e-05 24.9 0.0 0.063 13.2 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase NACHT PF05729.12 PIK47635.1 - 1.9e-05 24.6 0.0 0.028 14.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.6 PIK47635.1 - 7.2e-05 22.6 4.1 0.2 11.3 0.1 2.9 2 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 PIK47635.1 - 9.2e-05 22.1 0.1 0.42 10.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_6 PF12837.7 PIK47635.1 - 0.00016 21.6 1.5 0.00016 21.6 1.5 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.6 PIK47635.1 - 0.00024 21.4 0.0 0.086 13.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 PIK47635.1 - 0.00037 20.6 11.2 0.0027 17.8 0.6 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.22 PIK47635.1 - 0.00077 19.1 1.8 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 PIK47635.1 - 0.0011 19.3 0.0 1.4 9.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 PIK47635.1 - 0.0011 19.1 0.0 0.57 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 PIK47635.1 - 0.0018 18.2 0.0 0.44 10.5 0.0 2.7 2 0 0 2 2 2 1 Rad17 P-loop domain TsaE PF02367.17 PIK47635.1 - 0.0051 16.8 0.1 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_2 PF12797.7 PIK47635.1 - 0.0052 16.8 0.4 0.0052 16.8 0.4 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_24 PF13479.6 PIK47635.1 - 0.0056 16.4 2.1 0.36 10.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.6 PIK47635.1 - 0.0059 17.1 7.0 0.039 14.4 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 PIK47635.1 - 0.011 16.3 0.0 5.7 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 PIK47635.1 - 0.011 16.0 0.5 2 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 PIK47635.1 - 0.014 15.5 11.6 0.03 14.5 11.6 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain AAA_5 PF07728.14 PIK47635.1 - 0.015 15.3 0.1 1.7 8.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Fer4_21 PF14697.6 PIK47635.1 - 0.022 14.9 13.6 0.063 13.4 13.6 1.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_30 PF13604.6 PIK47635.1 - 0.028 14.1 0.1 2.5 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 PIK47635.1 - 0.029 14.1 0.4 7 6.3 0.0 2.7 3 0 0 3 3 2 0 Thymidylate kinase Fer4_16 PF13484.6 PIK47635.1 - 0.03 15.2 1.2 0.03 15.2 1.2 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 PIK47635.1 - 0.048 14.2 0.7 0.048 14.2 0.7 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain FtsK_SpoIIIE PF01580.18 PIK47635.1 - 0.068 12.5 0.2 2.6 7.3 0.0 2.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_14 PF13173.6 PIK47635.1 - 0.074 13.1 0.7 25 4.9 0.5 3.1 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK47635.1 - 0.081 12.4 0.1 2.2 7.8 0.0 2.5 3 0 0 3 3 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 PIK47635.1 - 0.087 12.1 0.0 7.5 5.8 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin DnaB_C PF03796.15 PIK47635.1 - 0.11 11.8 0.1 2 7.7 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain VirE PF05272.11 PIK47635.1 - 0.13 12.0 0.0 8.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E NTPase_1 PF03266.15 PIK47635.1 - 0.43 10.5 2.2 19 5.1 0.0 3.1 3 0 0 3 3 3 0 NTPase NB-ARC PF00931.22 PIK47635.1 - 0.44 9.7 1.8 13 4.9 0.3 2.7 2 1 1 3 3 3 0 NB-ARC domain MMR_HSR1 PF01926.23 PIK47635.1 - 0.47 10.5 4.0 9.9 6.3 0.0 3.0 3 1 0 3 3 3 0 50S ribosome-binding GTPase Fer4_4 PF12800.7 PIK47635.1 - 1.1 9.9 14.3 0.58 10.8 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 PIK47635.1 - 1.4 9.4 9.0 0.32 11.5 0.7 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 PIK47635.1 - 3.1 8.5 14.8 0.077 13.6 2.9 2.4 1 1 2 3 3 3 0 4Fe-4S dicluster domain Cyclin_N PF00134.23 PIK47636.1 - 1.9e-23 82.6 0.1 3.9e-23 81.6 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK47636.1 - 3.6e-07 30.3 0.2 1.9e-05 24.7 0.1 2.4 2 0 0 2 2 2 2 Cyclin, C-terminal domain Glycos_transf_2 PF00535.26 PIK47637.1 - 5.5e-25 88.1 0.0 7.2e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 PIK47637.1 - 8.4e-07 29.1 0.0 1.1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 PIK47637.1 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF2878 PF11086.8 PIK47637.1 - 0.18 12.0 1.1 0.26 11.5 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2878) Myotub-related PF06602.14 PIK47638.1 - 3.8e-130 433.9 0.2 4.8e-130 433.6 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 PIK47638.1 - 2.8e-10 40.2 6.4 5.9e-10 39.1 6.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger DSPc PF00782.20 PIK47638.1 - 0.0025 17.6 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK47638.1 - 0.0031 17.1 0.0 0.0067 16.0 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase GRAM PF02893.20 PIK47638.1 - 0.0087 15.9 0.0 0.033 14.1 0.0 1.9 2 0 0 2 2 2 1 GRAM domain CbiQ PF02361.16 PIK47638.1 - 0.041 13.5 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Cobalt transport protein Y_phosphatase3 PF13350.6 PIK47638.1 - 0.079 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family 7tm_3 PF00003.22 PIK47639.1 - 5.6e-25 88.5 1.3 6e-25 88.4 1.3 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR RVT_1 PF00078.27 PIK47640.1 - 0.00032 20.3 0.0 0.00052 19.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DAGK_cat PF00781.24 PIK47641.1 - 5.7e-22 77.7 0.1 8.2e-22 77.2 0.1 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Tim54 PF11711.8 PIK47641.1 - 8.7e-06 24.8 0.0 1.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 NAD_kinase PF01513.21 PIK47641.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 ATP-NAD kinase MH2 PF03166.14 PIK47643.1 - 5.4e-76 254.9 0.9 6.6e-76 254.7 0.9 1.1 1 0 0 1 1 1 1 MH2 domain IRF-3 PF10401.9 PIK47643.1 - 0.00055 19.8 0.0 0.00081 19.2 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 PIK47643.1 - 0.11 12.5 0.4 0.24 11.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) MH1 PF03165.16 PIK47644.1 - 4.8e-44 148.8 1.2 6e-44 148.5 1.2 1.1 1 0 0 1 1 1 1 MH1 domain GreA_GreB PF01272.19 PIK47644.1 - 0.045 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Transcription elongation factor, GreA/GreB, C-term cNMP_binding PF00027.29 PIK47647.1 - 1.4e-13 50.7 0.0 2.3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RIIa PF02197.17 PIK47647.1 - 7.3e-12 44.8 0.2 1.8e-11 43.5 0.1 1.7 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit Pkinase PF00069.25 PIK47648.1 - 0.0072 15.7 0.0 0.053 12.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Adeno_E3_CR2 PF02439.15 PIK47648.1 - 0.73 9.6 6.4 1.2 8.9 6.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EamA PF00892.20 PIK47649.1 - 3.9e-08 33.6 25.5 3e-05 24.2 21.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 PIK47649.1 - 0.47 9.6 14.2 1.1 8.5 13.9 1.8 1 1 0 1 1 1 0 UAA transporter family Exo_endo_phos_2 PF14529.6 PIK47650.1 - 3.1e-05 23.8 0.8 0.016 15.0 0.2 2.7 1 1 1 2 2 2 2 Endonuclease-reverse transcriptase RT_RNaseH_2 PF17919.1 PIK47652.1 - 4.3e-30 103.7 0.0 9e-30 102.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47652.1 - 1.2e-23 83.3 0.1 3.2e-23 82.0 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47653.1 - 8.4e-27 94.1 0.2 9.8e-27 93.9 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Parvo_coat PF00740.18 PIK47653.1 - 0.19 10.4 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 gag-asp_proteas PF13975.6 PIK47654.1 - 0.00011 22.7 0.0 0.00024 21.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK47654.1 - 0.00015 22.3 0.0 0.00031 21.3 0.0 1.6 1 1 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 PIK47654.1 - 0.015 15.1 0.2 1.3 8.8 0.1 2.2 1 1 1 2 2 2 0 Aspartyl protease 5_3_exonuc_N PF02739.16 PIK47656.1 - 0.075 12.9 0.3 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain RVT_1 PF00078.27 PIK47658.1 - 1.5e-32 113.0 0.5 2.1e-32 112.4 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trypan_PARP PF05887.11 PIK47659.1 - 0.0033 17.4 4.1 0.0035 17.3 4.1 1.1 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.12 PIK47659.1 - 0.14 11.8 10.9 0.16 11.6 10.9 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) SRCR PF00530.18 PIK47660.1 - 1.6e-257 834.0 62.6 7.9e-29 100.1 0.7 10.1 10 0 0 10 10 10 10 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47660.1 - 1.6e-51 172.8 25.6 1.8e-08 34.8 0.0 9.5 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47660.1 - 1.9e-29 102.4 0.1 0.52 10.9 0.0 9.6 9 0 0 9 9 9 9 Hepsin, SRCR domain PEP-utilizers PF00391.23 PIK47660.1 - 2.2e-15 56.1 1.1 1.9 8.3 0.0 7.4 7 0 0 7 7 7 6 PEP-utilising enzyme, mobile domain TcfC PF16967.5 PIK47660.1 - 2.2e-05 23.8 10.4 37 3.9 0.0 7.7 8 0 0 8 8 8 0 E-set like domain Arylsulfotran_2 PF14269.6 PIK47660.1 - 0.067 12.5 0.2 1.9e+02 1.2 0.0 5.2 7 0 0 7 7 7 0 Arylsulfotransferase (ASST) SRCR PF00530.18 PIK47661.1 - 6e-107 350.8 22.5 8.5e-28 96.8 0.7 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47661.1 - 1.2e-24 86.7 7.2 7.4e-05 23.2 0.0 4.3 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47661.1 - 4.6e-16 59.3 0.0 0.042 14.4 0.0 4.4 4 0 0 4 4 4 4 Hepsin, SRCR domain bPH_1 PF08000.11 PIK47661.1 - 0.011 15.8 0.0 17 5.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial PH domain SapB_2 PF03489.17 PIK47661.1 - 0.046 13.8 4.8 58 3.9 0.0 6.1 9 0 0 9 9 9 0 Saposin-like type B, region 2 VP4_haemagglut PF00426.18 PIK47661.1 - 0.12 12.6 0.0 22 5.2 0.0 2.3 2 0 0 2 2 2 0 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain Period_C PF12114.8 PIK47661.1 - 0.29 10.7 0.5 17 4.9 0.0 2.7 3 0 0 3 3 3 0 Period protein 2/3C-terminal region TPKR_C2 PF16920.5 PIK47661.1 - 0.47 10.6 10.1 2.2 8.5 0.2 4.2 4 0 0 4 4 4 0 Tyrosine-protein kinase receptor C2 Ig-like domain SRCR PF00530.18 PIK47662.1 - 1.5e-54 182.6 7.0 6.6e-27 93.9 1.2 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47662.1 - 1.3e-12 48.1 1.6 3.7e-05 24.2 0.1 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47662.1 - 2.2e-09 37.8 0.1 0.0028 18.2 0.1 2.4 2 1 0 2 2 2 2 Hepsin, SRCR domain YecR PF13992.6 PIK47662.1 - 0.0044 17.3 0.2 4.9 7.5 0.0 3.0 2 2 0 2 2 2 2 YecR-like lipoprotein BetaGal_dom4_5 PF13364.6 PIK47662.1 - 0.066 13.8 0.0 7 7.3 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain VP4_haemagglut PF00426.18 PIK47662.1 - 0.15 12.3 0.0 14 5.8 0.0 2.1 2 0 0 2 2 2 0 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain bPH_1 PF08000.11 PIK47662.1 - 0.16 12.1 0.0 6.9 6.8 0.0 2.1 2 0 0 2 2 2 0 Bacterial PH domain Bac_chlorC PF02043.17 PIK47662.1 - 0.17 11.9 0.2 20 5.3 0.0 2.3 2 0 0 2 2 2 0 Bacteriochlorophyll C binding protein SRCR PF00530.18 PIK47663.1 - 1.2e-27 96.3 0.4 1.4e-27 96.1 0.4 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47663.1 - 0.00015 22.3 0.3 0.00019 21.9 0.3 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK47664.1 - 3.3e-80 265.0 15.2 4.8e-29 100.8 2.1 3.1 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47664.1 - 5.1e-20 71.8 6.6 8.6e-07 29.4 0.2 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47664.1 - 8.2e-09 36.0 0.1 0.13 12.7 0.1 3.5 3 0 0 3 3 3 3 Hepsin, SRCR domain SapB_2 PF03489.17 PIK47664.1 - 0.05 13.7 0.1 1.1e+02 3.1 0.0 4.2 4 0 0 4 4 4 0 Saposin-like type B, region 2 SRCR PF00530.18 PIK47665.1 - 6.7e-54 180.6 9.8 1.6e-26 92.7 1.6 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK47665.1 - 3e-12 46.9 3.1 4.8e-05 23.8 0.3 2.4 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK47665.1 - 2.6e-07 31.1 2.8 0.018 15.5 0.1 2.9 3 2 0 3 3 3 2 Hepsin, SRCR domain Period_C PF12114.8 PIK47665.1 - 0.032 13.8 0.0 1.6 8.3 0.0 2.1 2 0 0 2 2 2 0 Period protein 2/3C-terminal region SH3_17 PF18350.1 PIK47665.1 - 0.068 13.1 0.2 20 5.2 0.0 2.6 2 0 0 2 2 2 0 Restriction endonuclease SH3 domain SapB_2 PF03489.17 PIK47665.1 - 0.083 13.0 1.0 53 4.0 0.0 3.8 4 0 0 4 4 4 0 Saposin-like type B, region 2 DUF4652 PF15525.6 PIK47665.1 - 0.14 11.9 0.5 18 5.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4652) ATP11 PF06644.11 PIK47667.1 - 1.6e-54 185.6 4.4 1.9e-54 185.3 4.4 1.1 1 0 0 1 1 1 1 ATP11 protein NuDC PF16273.5 PIK47667.1 - 0.082 13.5 6.7 0.18 12.4 5.5 2.2 2 0 0 2 2 2 0 Nuclear distribution C domain Borrelia_REV PF03978.13 PIK47667.1 - 0.2 11.6 1.2 0.34 10.8 1.2 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Peptidase_S49_N PF08496.10 PIK47667.1 - 5.7 7.0 6.8 11 6.1 6.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Nuc_sug_transp PF04142.15 PIK47668.1 - 1.3e-128 428.6 15.8 1.5e-128 428.4 15.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 PIK47668.1 - 1.4e-07 31.7 25.6 1.6e-06 28.3 3.7 2.5 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 PIK47668.1 - 0.0005 19.1 2.5 0.0005 19.1 2.5 1.6 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 PIK47668.1 - 0.003 16.8 13.4 0.0065 15.7 13.4 1.7 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.6 PIK47668.1 - 0.023 14.3 10.7 0.2 11.2 10.8 2.1 1 1 0 1 1 1 0 Putative multidrug resistance efflux transporter PUNUT PF16913.5 PIK47668.1 - 1 8.5 19.9 0.28 10.3 15.8 2.1 2 1 0 2 2 2 0 Purine nucleobase transmembrane transport Multi_Drug_Res PF00893.19 PIK47668.1 - 1.2 9.9 12.2 0.21 12.3 1.9 3.0 2 1 0 2 2 2 0 Small Multidrug Resistance protein TMEM234 PF10639.9 PIK47668.1 - 3.2 7.8 10.9 0.35 10.9 1.1 2.6 3 0 0 3 3 3 0 Putative transmembrane family 234 MerC PF03203.14 PIK47668.1 - 8.6 6.8 9.7 11 6.5 1.8 2.7 1 1 1 2 2 2 0 MerC mercury resistance protein fn3 PF00041.21 PIK47669.1 - 2.3e-42 143.2 17.9 1e-10 41.8 0.0 7.3 7 0 0 7 7 7 6 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK47669.1 - 1.3e-05 25.7 14.9 0.047 14.3 0.3 5.6 6 0 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 PIK47669.1 - 0.0002 21.5 0.1 0.00068 19.8 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin V-set domain Tissue_fac PF01108.17 PIK47669.1 - 0.00041 20.2 1.4 0.033 14.1 0.1 4.1 5 0 0 5 5 5 1 Tissue factor Lep_receptor_Ig PF06328.11 PIK47669.1 - 0.0019 18.1 0.8 0.13 12.2 0.6 3.4 2 1 0 2 2 2 1 Ig-like C2-type domain Ig_3 PF13927.6 PIK47669.1 - 0.052 14.1 0.9 0.39 11.4 0.2 3.0 2 0 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 PIK47669.1 - 0.065 13.6 0.3 0.28 11.5 0.3 2.2 1 0 0 1 1 1 0 Immunoglobulin domain TMEM154 PF15102.6 PIK47669.1 - 0.075 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family GPI-anchored PF10342.9 PIK47669.1 - 5.8 7.7 9.4 1.2 9.9 0.1 4.1 3 1 1 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NPL PF17800.1 PIK47670.1 - 7.5e-15 55.4 1.1 1.5e-14 54.4 0.1 2.0 2 0 0 2 2 2 1 Nucleoplasmin-like domain Cdc13_OB2 PF18691.1 PIK47670.1 - 0.91 9.6 3.0 3.5 7.7 3.0 1.9 1 1 0 1 1 1 0 Cell division control protein 13, OB2 domain Sulfotransfer_2 PF03567.14 PIK47671.1 - 8.4e-42 143.8 3.9 8.4e-42 143.8 3.9 1.7 2 0 0 2 2 2 1 Sulfotransferase family TetR_C_23 PF17931.1 PIK47671.1 - 0.037 14.2 0.2 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Proteasome PF00227.26 PIK47672.1 - 1.8e-60 203.7 0.0 2.7e-60 203.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 PIK47672.1 - 4.6e-10 39.0 0.0 8.1e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PBP_dimer PF03717.15 PIK47672.1 - 0.046 14.1 0.0 14 6.0 0.0 2.2 2 0 0 2 2 2 0 Penicillin-binding Protein dimerisation domain Ras PF00071.22 PIK47673.1 - 4.7e-40 136.8 0.0 6.4e-40 136.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK47673.1 - 1.6e-19 70.2 0.1 2.8e-19 69.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK47673.1 - 3.1e-09 36.5 0.0 4.7e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK47673.1 - 0.0085 15.6 0.0 0.013 15.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain KRTAP7 PF15034.6 PIK47673.1 - 0.11 13.4 1.1 0.23 12.5 1.1 1.5 1 0 0 1 1 1 0 KRTAP type 7 family zf-H2C2_2 PF13465.6 PIK47674.1 - 4.3e-15 55.3 19.4 2.3e-08 34.1 0.6 4.6 4 0 0 4 4 4 3 Zinc-finger double domain NPL PF17800.1 PIK47674.1 - 4.5e-15 56.1 0.0 1.3e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-C2H2 PF00096.26 PIK47674.1 - 2.9e-13 49.5 28.3 0.00094 19.5 0.3 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK47674.1 - 3.1e-08 33.8 25.1 0.027 15.3 0.3 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger C1_1 PF00130.22 PIK47674.1 - 0.0025 17.6 5.3 0.021 14.7 0.1 3.2 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_jaz PF12171.8 PIK47674.1 - 0.0027 17.9 16.5 0.36 11.2 0.2 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 PIK47674.1 - 0.021 15.1 1.5 0.021 15.1 1.5 2.6 2 0 0 2 2 2 0 zinc-finger-containing domain zf-met PF12874.7 PIK47674.1 - 0.043 14.2 0.8 0.043 14.2 0.8 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-AN1 PF01428.16 PIK47674.1 - 0.1 12.8 10.7 3.3 8.0 0.1 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger PyrI_C PF02748.15 PIK47674.1 - 0.17 11.8 13.0 0.43 10.5 0.1 4.2 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_4 PF07975.12 PIK47674.1 - 0.28 11.5 12.5 0.19 12.0 2.8 2.7 2 0 0 2 2 2 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 PIK47674.1 - 0.66 10.8 6.5 1.8 9.4 1.2 2.6 2 0 0 2 2 2 0 zinc-ribbon family Zn-ribbon_8 PF09723.10 PIK47674.1 - 2.1 8.5 14.2 18 5.6 0.6 4.3 3 1 1 4 4 4 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 PIK47674.1 - 2.5 8.1 7.8 1.9 8.5 0.0 3.2 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Ogr_Delta PF04606.12 PIK47674.1 - 5.2 7.1 7.0 1.9 8.5 3.5 2.1 2 0 0 2 2 1 0 Ogr/Delta-like zinc finger zf-C2H2_11 PF16622.5 PIK47674.1 - 7 6.5 16.4 1.9 8.3 0.3 4.2 4 0 0 4 4 3 0 zinc-finger C2H2-type zf-nanos PF05741.13 PIK47674.1 - 8.5 6.7 14.7 5.8 7.2 2.4 4.2 4 1 0 4 4 4 0 Nanos RNA binding domain Clat_adaptor_s PF01217.20 PIK47676.1 - 2e-26 92.7 1.1 3.1e-26 92.0 0.1 1.7 2 0 0 2 2 2 1 Clathrin adaptor complex small chain Mhr1 PF12829.7 PIK47676.1 - 1.4 9.1 5.4 98 3.1 0.1 3.7 1 1 2 3 3 3 0 Transcriptional regulation of mitochondrial recombination 2CSK_N PF08521.10 PIK47676.1 - 1.5 8.9 4.5 31 4.6 0.2 3.0 1 1 2 3 3 3 0 Two-component sensor kinase N-terminal HEAT PF02985.22 PIK47677.1 - 5.9e-09 35.4 0.0 0.031 14.5 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 PIK47677.1 - 0.00013 22.0 0.1 0.0071 16.4 0.1 2.4 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Pkinase PF00069.25 PIK47677.1 - 0.00046 19.6 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CLASP_N PF12348.8 PIK47677.1 - 0.071 12.7 0.1 0.61 9.6 0.1 2.1 1 1 0 2 2 2 0 CLASP N terminal Kinase-like PF14531.6 PIK47677.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like UBA_4 PF14555.6 PIK47678.1 - 1.3e-08 34.5 0.1 1.9e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 PIK47678.1 - 0.0017 18.0 0.1 0.0028 17.2 0.1 1.3 1 0 0 1 1 1 1 TAP C-terminal domain Clusterin PF01093.17 PIK47678.1 - 0.11 11.5 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Clusterin zf-C3HC4_3 PF13920.6 PIK47679.1 - 5.7e-15 54.9 8.1 1.1e-14 54.0 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK47679.1 - 2.3e-07 30.5 10.7 4.6e-07 29.6 10.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK47679.1 - 6.4e-06 26.4 11.8 1.4e-05 25.3 11.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 PIK47679.1 - 0.00099 19.0 9.0 0.0021 18.0 9.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK47679.1 - 0.083 12.8 11.3 0.15 12.0 11.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 PIK47679.1 - 2.5 8.0 9.1 5.7 6.8 9.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Aa_trans PF01490.18 PIK47680.1 - 1.4e-52 178.8 17.9 1.8e-52 178.4 17.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 PIK47680.1 - 4.9e-08 32.4 7.9 4.9e-08 32.4 7.9 1.9 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DUF1731 PF08338.11 PIK47681.1 - 0.045 13.6 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1731) WD40 PF00400.32 PIK47682.1 - 0.00016 22.4 0.0 4.3 8.4 0.0 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat CNH PF00780.22 PIK47682.1 - 0.0017 18.0 0.0 0.42 10.2 0.0 3.4 2 2 0 2 2 2 2 CNH domain Corazonin PF17308.2 PIK47683.1 - 0.058 13.8 0.7 0.11 12.9 0.3 1.7 1 1 0 1 1 1 0 Pro-corazonin zf-C3HC4 PF00097.25 PIK47686.1 - 3.8e-09 36.3 14.8 5.6e-09 35.7 14.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47686.1 - 1.6e-08 34.7 12.1 2.4e-08 34.1 12.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK47686.1 - 2.5e-08 33.8 14.6 3.9e-08 33.2 14.6 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK47686.1 - 3.1e-08 33.7 14.2 4.5e-08 33.1 14.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK47686.1 - 1.1e-07 31.5 13.8 1.9e-07 30.8 13.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK47686.1 - 1.2e-07 31.4 13.5 1.6e-07 31.0 13.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47686.1 - 2.3e-06 27.5 12.9 3.4e-06 26.9 12.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK47686.1 - 0.0023 17.8 14.0 0.0036 17.1 14.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK47686.1 - 0.028 14.7 10.6 0.63 10.4 10.6 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 PIK47686.1 - 0.6 9.9 14.9 0.084 12.6 10.7 1.9 2 1 0 2 2 2 0 RING-like zinc finger zf-B_box PF00643.24 PIK47687.1 - 4e-13 49.3 15.0 1.2e-08 34.9 4.6 4.3 4 0 0 4 4 3 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK47687.1 - 1.8e-07 31.1 10.4 1.8e-07 31.1 10.4 3.6 3 1 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47687.1 - 3.9e-07 29.8 14.5 3.9e-07 29.8 14.5 3.9 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK47687.1 - 1.7e-06 27.8 13.9 1.7e-06 27.8 13.9 3.8 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK47687.1 - 2.4e-06 27.6 13.6 2.4e-06 27.6 13.6 4.2 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK47687.1 - 2.9e-06 27.5 12.2 2.9e-06 27.5 12.2 3.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK47687.1 - 3.5e-05 23.5 13.7 3.5e-05 23.5 13.7 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47687.1 - 3.9e-05 23.5 12.9 3.9e-05 23.5 12.9 4.0 3 0 0 3 3 3 1 zinc-RING finger domain ZYG-11_interact PF05884.12 PIK47687.1 - 0.02 14.3 0.7 0.032 13.7 0.7 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 COQ7 PF03232.13 PIK47687.1 - 0.14 11.9 0.7 0.26 11.0 0.7 1.4 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 PspA_IM30 PF04012.12 PIK47687.1 - 0.16 11.5 4.3 0.24 11.0 4.3 1.1 1 0 0 1 1 1 0 PspA/IM30 family Helo_like_N PF17111.5 PIK47687.1 - 0.41 10.0 6.5 0.89 8.9 6.5 1.5 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Myb_DNA-bind_5 PF13873.6 PIK47687.1 - 0.51 10.4 3.0 1.5 8.9 2.7 1.9 2 0 0 2 2 1 0 Myb/SANT-like DNA-binding domain IBR PF01485.21 PIK47687.1 - 3.2 8.0 31.8 0.33 11.2 12.0 4.1 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain PP2C PF00481.21 PIK47688.1 - 1.8e-08 34.4 0.0 2e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 PIK47689.1 - 5.8e-57 193.3 3.3 7.2e-57 193.0 3.3 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK47689.1 - 1.6e-07 31.2 0.0 4e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C DNA_pol_phi PF04931.13 PIK47689.1 - 0.022 12.9 24.8 0.029 12.5 24.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 PIK47689.1 - 2.1 7.6 29.8 3.9 6.7 29.8 1.4 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 PIK47689.1 - 3.9 5.6 31.9 4.3 5.4 31.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 PIK47689.1 - 6.3 6.1 22.0 9.5 5.5 22.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CiPC PF15800.5 PIK47689.1 - 8.3 6.0 10.7 11 5.6 10.7 1.2 1 0 0 1 1 1 0 Clock interacting protein circadian Ank_2 PF12796.7 PIK47690.1 - 6.1e-26 90.8 0.0 5.9e-12 46.0 0.0 2.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK47690.1 - 6.3e-15 55.3 0.0 1e-09 38.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK47690.1 - 3.1e-11 42.5 0.0 0.0016 18.8 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK47690.1 - 8.5e-10 38.7 0.0 2.5e-06 27.7 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK47690.1 - 2.7e-06 27.6 0.1 0.0023 18.3 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeat DUF5641 PF18701.1 PIK47691.1 - 1.6e-24 85.8 2.1 3.8e-24 84.7 2.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 PIK47691.1 - 1.2e-06 28.6 0.6 3.2e-06 27.2 0.6 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK47691.1 - 2e-05 24.8 0.0 3.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF1758 PF05585.12 PIK47692.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF1758) zf-CCHC PF00098.23 PIK47692.1 - 0.069 13.3 1.9 0.069 13.3 1.9 2.7 3 0 0 3 3 3 0 Zinc knuckle Asp_protease_2 PF13650.6 PIK47692.1 - 0.15 12.7 0.1 0.4 11.3 0.0 1.7 2 0 0 2 2 2 0 Aspartyl protease FDX-ACB PF03147.14 PIK47693.1 - 1.1e-12 48.2 0.0 2.6e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain LMSTEN PF07988.12 PIK47693.1 - 0.086 12.3 0.1 2.9 7.4 0.0 2.6 2 0 0 2 2 2 0 LMSTEN motif FDX-ACB PF03147.14 PIK47694.1 - 3.7e-13 49.7 0.0 6.1e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Amidase PF01425.21 PIK47695.1 - 1.3e-98 330.9 0.0 1.6e-98 330.6 0.0 1.0 1 0 0 1 1 1 1 Amidase JmjC PF02373.22 PIK47696.1 - 0.037 14.5 0.1 0.48 10.9 0.1 2.6 2 0 0 2 2 2 0 JmjC domain, hydroxylase Use1 PF09753.9 PIK47696.1 - 4.6 6.9 10.7 6.9 6.3 2.1 2.9 2 0 0 2 2 2 0 Membrane fusion protein Use1 CLCA PF08434.11 PIK47697.1 - 1.5e-08 34.4 0.0 2.4e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal fn3 PF00041.21 PIK47697.1 - 0.0043 17.4 0.1 0.039 14.3 0.0 2.6 2 0 0 2 2 2 1 Fibronectin type III domain VWA_2 PF13519.6 PIK47697.1 - 0.024 15.3 0.0 0.057 14.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain Interfer-bind PF09294.10 PIK47697.1 - 0.1 12.9 0.0 4.3 7.7 0.0 2.6 1 1 1 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III CLCA PF08434.11 PIK47698.1 - 1.2e-20 74.0 0.0 2.1e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Swi3 PF07962.12 PIK47698.1 - 0.099 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Replication Fork Protection Component Swi3 GIY-YIG PF01541.24 PIK47699.1 - 3e-05 24.2 0.0 6.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK47699.1 - 8.4e-05 22.2 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HYR PF02494.16 PIK47700.1 - 8.7e-20 70.8 14.3 1.3e-09 38.2 4.6 2.3 2 0 0 2 2 2 2 HYR domain DUF1833 PF08875.11 PIK47700.1 - 0.027 14.0 0.9 0.98 8.9 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1833) Glyco_transf_10 PF00852.19 PIK47701.1 - 2.4e-36 125.1 0.0 2.6e-36 125.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DSBA PF01323.20 PIK47702.1 - 0.0057 16.5 0.1 0.018 14.8 0.0 1.7 2 0 0 2 2 2 1 DSBA-like thioredoxin domain Gallidermin PF02052.15 PIK47702.1 - 0.0087 16.4 0.4 0.035 14.4 0.1 2.1 2 0 0 2 2 2 1 Gallidermin Thioredoxin_4 PF13462.6 PIK47702.1 - 0.04 14.1 0.0 0.046 13.9 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin CNH PF00780.22 PIK47705.1 - 5.8e-44 150.7 0.7 2.6e-43 148.6 0.3 1.9 2 0 0 2 2 2 1 CNH domain PH PF00169.29 PIK47705.1 - 1.1e-07 32.3 0.1 9.8e-07 29.2 0.0 2.5 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 PIK47705.1 - 1.2e-05 25.1 11.2 2.3e-05 24.2 11.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 PIK47705.1 - 5.6 7.1 7.9 18 5.6 7.9 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger Filament PF00038.21 PIK47706.1 - 0.00095 18.8 14.6 0.00095 18.8 14.6 8.2 1 1 6 7 7 7 2 Intermediate filament protein BRE1 PF08647.11 PIK47706.1 - 0.0011 19.0 23.3 0.0011 19.0 23.3 10.9 4 3 7 11 11 11 3 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 PIK47706.1 - 0.0052 16.8 21.0 0.0052 16.8 21.0 9.0 1 1 7 9 9 9 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KASH_CCD PF14662.6 PIK47706.1 - 0.008 16.0 22.9 0.008 16.0 22.9 7.5 1 1 6 7 7 7 2 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 PIK47706.1 - 0.19 12.0 0.1 0.19 12.0 0.1 13.3 12 3 2 14 14 14 0 Homeobox associated leucine zipper Lebercilin PF15619.6 PIK47707.1 - 0.007 16.0 33.6 0.007 16.0 33.6 4.0 1 1 2 4 4 4 2 Ciliary protein causing Leber congenital amaurosis disease Leu_zip PF15294.6 PIK47707.1 - 1.6 8.2 66.4 0.037 13.6 19.3 3.4 1 1 2 3 3 3 0 Leucine zipper TPR_MLP1_2 PF07926.12 PIK47707.1 - 3.1 7.9 75.5 3.1 7.9 10.1 4.2 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 PIK47707.1 - 5.8 7.4 80.6 0.8 10.2 12.4 5.3 1 1 4 5 5 5 0 Apg6 coiled-coil region HAP1_N PF04849.13 PIK47708.1 - 1.1e-08 34.6 5.7 1.1e-08 34.6 5.7 2.0 1 1 0 2 2 2 1 HAP1 N-terminal conserved region CdvA PF18822.1 PIK47708.1 - 0.0094 15.8 10.3 0.015 15.1 10.3 1.4 1 0 0 1 1 1 1 CdvA-like coiled-coil domain DUF4164 PF13747.6 PIK47708.1 - 0.012 15.9 13.6 0.02 15.1 2.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Phage_lysis PF03245.13 PIK47708.1 - 0.02 15.0 6.3 0.31 11.2 1.8 2.3 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein Pedibin PF08182.11 PIK47708.1 - 0.02 14.7 6.1 0.17 11.7 0.0 3.5 3 0 0 3 3 3 0 Pedibin/Hym-346 family MPTase-PolyVal PF18818.1 PIK47708.1 - 0.023 14.8 4.8 2.1 8.4 0.5 3.0 1 1 2 3 3 3 0 Metallopeptidase superfamily domain DUF4407 PF14362.6 PIK47708.1 - 0.084 12.2 7.6 0.11 11.8 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMMR_N PF15905.5 PIK47708.1 - 0.25 10.8 16.6 0.37 10.2 16.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Exonuc_VII_L PF02601.15 PIK47708.1 - 0.67 9.5 7.6 0.8 9.2 7.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lectin_N PF03954.14 PIK47708.1 - 0.88 9.3 7.1 0.17 11.6 2.8 2.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Nas2_N PF18265.1 PIK47708.1 - 1.1 9.2 7.9 1.3 9.0 0.7 3.2 2 1 2 4 4 4 0 Nas2 N_terminal domain GvpL_GvpF PF06386.11 PIK47708.1 - 1.2 9.0 10.2 0.6 10.0 8.0 1.5 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF V_ATPase_I PF01496.19 PIK47708.1 - 2.7 5.8 6.7 3.5 5.4 6.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Med21 PF11221.8 PIK47708.1 - 7.2 6.9 21.6 0.076 13.3 4.8 3.0 2 1 1 3 3 3 0 Subunit 21 of Mediator complex DUF1664 PF07889.12 PIK47708.1 - 7.5 6.6 9.4 6.2 6.9 5.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 PIK47708.1 - 8.5 6.6 22.7 0.13 12.5 9.4 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 APG6_N PF17675.1 PIK47709.1 - 4.5e-05 24.0 25.5 0.0054 17.3 6.5 3.5 3 0 0 3 3 3 3 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 PIK47709.1 - 0.00044 20.3 24.0 0.0042 17.1 2.5 3.6 3 0 0 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.13 PIK47709.1 - 0.0051 16.6 1.6 0.0051 16.6 1.6 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.11 PIK47709.1 - 0.014 16.0 18.2 0.16 12.5 1.3 3.6 2 2 0 3 3 3 0 Syntaxin 6, N-terminal FPP PF05911.11 PIK47709.1 - 0.015 13.5 0.7 0.015 13.5 0.7 3.1 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil FliJ PF02050.16 PIK47709.1 - 0.023 14.9 1.2 0.023 14.9 1.2 4.3 3 2 2 5 5 5 0 Flagellar FliJ protein ATG16 PF08614.11 PIK47709.1 - 0.023 14.9 27.8 0.21 11.8 5.4 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF16 PF01519.16 PIK47709.1 - 0.027 15.0 0.8 0.027 15.0 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 PIK47709.1 - 0.037 14.2 18.7 0.53 10.4 1.4 3.5 3 0 0 3 3 3 0 Tropomyosin like Laminin_II PF06009.12 PIK47709.1 - 0.064 13.3 11.4 0.29 11.2 0.2 3.3 3 0 0 3 3 3 0 Laminin Domain II Mod_r PF07200.13 PIK47709.1 - 0.076 13.1 22.3 0.23 11.5 2.5 3.5 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Tropomyosin PF00261.20 PIK47709.1 - 0.11 11.8 18.9 0.56 9.5 1.6 3.2 3 0 0 3 3 3 0 Tropomyosin DUF4407 PF14362.6 PIK47709.1 - 0.17 11.2 13.4 0.77 9.0 0.5 2.7 1 1 0 3 3 3 0 Domain of unknown function (DUF4407) COG2 PF06148.11 PIK47709.1 - 0.24 11.5 9.0 0.87 9.7 0.3 3.2 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_GP20 PF06810.11 PIK47709.1 - 0.39 10.5 12.6 5.5 6.8 2.8 3.4 3 0 0 3 3 3 0 Phage minor structural protein GP20 BRE1 PF08647.11 PIK47709.1 - 0.52 10.4 15.2 0.33 11.1 0.4 3.7 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase DUF3450 PF11932.8 PIK47709.1 - 0.64 9.3 18.7 0.88 8.8 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) CENP-Q PF13094.6 PIK47709.1 - 0.66 10.2 29.3 0.14 12.4 12.6 3.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TPR_MLP1_2 PF07926.12 PIK47709.1 - 0.95 9.5 23.0 1.1 9.3 1.5 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 PIK47709.1 - 0.99 9.5 27.7 3.1 7.8 8.0 3.4 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus KELK PF15796.5 PIK47709.1 - 1 9.8 23.8 1.6 9.2 3.0 4.0 3 1 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF948 PF06103.11 PIK47709.1 - 1.2 9.4 6.1 9.4 6.6 1.2 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.6 PIK47709.1 - 1.9 8.6 33.0 1.8 8.7 4.2 5.1 4 1 0 4 4 3 0 Centrosome localisation domain of PPC89 GIT_CC PF16559.5 PIK47709.1 - 1.9 8.4 10.8 0.046 13.6 2.3 2.7 3 0 0 3 3 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Cnn_1N PF07989.11 PIK47709.1 - 2 8.6 18.9 0.22 11.7 2.6 4.0 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Swi5 PF07061.11 PIK47709.1 - 2.2 8.5 12.3 1.1 9.4 0.9 3.9 3 0 0 3 3 3 0 Swi5 DUF1664 PF07889.12 PIK47709.1 - 2.6 8.1 15.5 3.9 7.5 1.2 3.6 4 0 0 4 4 3 0 Protein of unknown function (DUF1664) PspA_IM30 PF04012.12 PIK47709.1 - 2.9 7.4 16.9 0.43 10.1 1.4 3.4 3 0 0 3 3 3 0 PspA/IM30 family HrpB7 PF09486.10 PIK47709.1 - 3.1 8.2 16.0 1.1 9.6 3.3 3.2 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) KfrA_N PF11740.8 PIK47709.1 - 4.1 8.1 16.5 0.76 10.5 1.0 3.4 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term DUF2046 PF09755.9 PIK47709.1 - 4.2 6.5 25.1 0.014 14.7 6.1 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein H4 (DUF2046) TMPIT PF07851.13 PIK47709.1 - 4.3 6.5 14.2 2.5 7.3 0.6 3.5 4 0 0 4 4 4 0 TMPIT-like protein DegS PF05384.11 PIK47709.1 - 4.8 6.7 13.5 1.6 8.2 0.4 3.1 3 0 0 3 3 3 0 Sensor protein DegS DUF3287 PF11690.8 PIK47709.1 - 7.4 6.3 8.7 0.36 10.6 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Jnk-SapK_ap_N PF09744.9 PIK47709.1 - 9.4 6.4 23.1 12 6.1 4.8 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 TRPM_tetra PF16519.5 PIK47709.1 - 9.9 6.4 10.6 1.2 9.2 1.1 3.6 3 1 0 4 4 4 0 Tetramerisation domain of TRPM Abhydrolase_1 PF00561.20 PIK47710.1 - 3.5e-21 76.0 0.0 2.9e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK47710.1 - 1.3e-14 54.0 0.0 2.5e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK47710.1 - 4.2e-14 53.7 0.0 6.8e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 PIK47710.1 - 1.3e-05 25.4 0.0 2.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 PIK47710.1 - 1.6e-05 24.8 0.2 0.00051 19.8 0.2 2.4 1 1 0 1 1 1 1 PGAP1-like protein Ribosomal_L18p PF00861.22 PIK47710.1 - 0.00014 22.2 0.0 0.00024 21.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Palm_thioest PF02089.15 PIK47710.1 - 0.0037 17.1 0.0 0.0058 16.5 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Ndr PF03096.14 PIK47710.1 - 0.0084 14.8 0.0 0.018 13.8 0.0 1.5 1 0 0 1 1 1 1 Ndr family DUF676 PF05057.14 PIK47710.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Chlorophyllase PF07224.11 PIK47710.1 - 0.038 13.0 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Torsin PF06309.11 PIK47710.1 - 0.044 13.9 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 Torsin Esterase PF00756.20 PIK47710.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Ubie_methyltran PF01209.18 PIK47711.1 - 4.6e-88 294.5 0.0 6e-88 294.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 PIK47711.1 - 5.6e-17 62.2 0.0 1.9e-16 60.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK47711.1 - 2.1e-16 60.4 0.0 2.1e-15 57.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK47711.1 - 2.9e-09 36.9 0.1 1.6e-08 34.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK47711.1 - 2.2e-07 31.5 0.0 5.3e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK47711.1 - 2.2e-05 24.4 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK47711.1 - 0.016 14.8 0.0 8.5 5.9 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.15 PIK47711.1 - 0.018 14.9 0.2 0.099 12.5 0.0 2.3 2 1 1 3 3 3 0 Hypothetical methyltransferase Methyltransf_5 PF01795.19 PIK47711.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 MraW methylase family UPF0020 PF01170.18 PIK47711.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF4042 PF13251.6 PIK47712.1 - 8.9e-61 204.8 6.0 6.1e-60 202.0 0.1 4.3 5 1 0 5 5 5 1 Domain of unknown function (DUF4042) HEAT PF02985.22 PIK47712.1 - 1.8e-18 65.0 10.3 0.0049 17.0 0.1 10.3 10 0 0 10 10 10 4 HEAT repeat HEAT_2 PF13646.6 PIK47712.1 - 1.5e-13 50.9 0.0 0.013 15.9 0.0 7.2 5 1 3 8 8 8 4 HEAT repeats HEAT_EZ PF13513.6 PIK47712.1 - 2.2e-09 37.6 10.5 0.2 12.2 0.1 8.4 8 2 0 8 8 8 3 HEAT-like repeat Arm PF00514.23 PIK47712.1 - 1.2e-05 25.2 4.4 0.075 13.1 0.1 5.8 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat DUF1981 PF09324.10 PIK47712.1 - 0.012 15.5 0.1 0.57 10.1 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) HEAT_PBS PF03130.16 PIK47712.1 - 0.033 14.8 0.8 3.1 8.7 0.0 4.3 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat UME PF08064.13 PIK47712.1 - 0.059 13.3 1.3 2.4 8.1 0.0 4.4 7 0 0 7 7 7 0 UME (NUC010) domain RIX1 PF08167.12 PIK47712.1 - 0.097 12.4 0.5 8.4 6.1 0.0 4.0 5 0 0 5 5 5 0 rRNA processing/ribosome biogenesis V-ATPase_H_C PF11698.8 PIK47712.1 - 0.1 12.7 7.3 16 5.7 0.0 5.3 6 1 0 6 6 6 0 V-ATPase subunit H Sulfotransfer_3 PF13469.6 PIK47713.1 - 4.3e-50 171.1 0.0 8.6e-50 170.1 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK47713.1 - 1.3e-05 24.9 0.1 0.00012 21.6 0.1 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Cyt-b5 PF00173.28 PIK47714.1 - 6.7e-10 39.0 0.1 1.2e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Med15 PF09606.10 PIK47715.1 - 4.4e-06 25.7 7.9 4.4e-06 25.7 7.9 2.1 1 1 1 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal KIX PF02172.16 PIK47715.1 - 0.011 15.9 0.1 0.025 14.8 0.1 1.6 1 0 0 1 1 1 0 KIX domain PAT1 PF09770.9 PIK47715.1 - 3.1 6.0 31.8 3.9 5.6 31.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 PIK47716.1 - 3.2e-54 184.9 8.0 5.3e-54 184.2 8.0 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DrrA_P4M PF14860.6 PIK47716.1 - 0.082 12.8 1.1 0.14 12.1 1.1 1.4 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain Hpt PF01627.23 PIK47716.1 - 0.096 13.0 0.8 0.18 12.1 0.4 1.7 1 1 0 1 1 1 0 Hpt domain CDC37_N PF03234.14 PIK47716.1 - 0.31 11.9 3.0 0.48 11.3 3.0 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DNA_pol_phi PF04931.13 PIK47717.1 - 1.5e-34 119.3 0.1 1.9e-34 118.9 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase phi DNA_pol_phi PF04931.13 PIK47718.1 - 4.1e-67 226.9 0.3 4.9e-67 226.7 0.3 1.0 1 0 0 1 1 1 1 DNA polymerase phi ISPD_C PF18706.1 PIK47719.1 - 0.016 14.9 1.2 0.023 14.3 1.2 1.2 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain CH PF00307.31 PIK47720.1 - 3.7e-22 78.6 0.0 4.3e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK47720.1 - 4.1e-07 29.7 0.0 6.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain RGS PF00615.19 PIK47722.1 - 4.3e-29 101.2 0.2 1.5e-15 57.5 0.3 2.4 2 0 0 2 2 2 2 Regulator of G protein signaling domain Tubulin PF00091.25 PIK47724.1 - 1e-50 172.7 0.1 1.2e-50 172.5 0.1 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 PIK47724.1 - 0.059 12.5 0.6 0.16 11.1 0.6 1.8 1 1 0 1 1 1 0 Tubulin like Misat_Tub_SegII PF10644.9 PIK47724.1 - 0.14 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain EF-hand_1 PF00036.32 PIK47725.1 - 2.6e-17 61.0 4.9 1.3e-05 24.4 1.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK47725.1 - 3.1e-15 54.7 3.3 3.4e-05 23.4 0.3 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 PIK47725.1 - 2.3e-13 48.9 5.1 7.3e-05 22.1 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 PIK47725.1 - 7.2e-13 48.8 7.0 2.9e-07 30.8 0.9 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK47725.1 - 3.7e-10 39.5 2.9 0.0042 16.9 0.4 3.2 2 1 1 3 3 3 3 EF-hand domain pair Caleosin PF05042.13 PIK47725.1 - 0.00038 20.4 0.1 0.021 14.7 0.1 2.1 1 1 1 2 2 2 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 PIK47725.1 - 0.00049 20.4 0.8 0.89 9.9 0.1 2.9 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 PIK47725.1 - 0.006 16.4 3.5 3.1 7.7 0.0 3.3 3 1 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 PIK47725.1 - 0.0086 16.3 0.3 2.5 8.4 0.1 2.6 2 1 0 2 2 2 2 Dockerin type I domain TRAPPC-Trs85 PF12739.7 PIK47727.1 - 5.1e-118 394.6 4.9 1.2e-117 393.4 4.9 1.5 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SMC_hinge PF06470.13 PIK47728.1 - 0.16 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain DUF4604 PF15377.6 PIK47729.1 - 8e-21 75.2 22.4 1.2e-20 74.6 22.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DUF4551 PF15087.6 PIK47729.1 - 0.38 9.6 7.4 0.36 9.6 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) adh_short_C2 PF13561.6 PIK47731.1 - 4.7e-56 190.0 0.0 5.5e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK47731.1 - 6.2e-48 162.9 0.1 7.3e-48 162.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK47731.1 - 1.3e-06 28.4 0.1 1.9e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK47731.1 - 0.0061 16.1 0.1 0.012 15.1 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PAX PF00292.18 PIK47732.1 - 2.3e-65 218.2 0.1 4e-65 217.4 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 PIK47732.1 - 3.2e-05 23.6 0.0 8.2e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 PIK47732.1 - 6.5e-05 23.5 0.1 0.0064 17.1 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_38 PF13936.6 PIK47732.1 - 0.12 12.2 0.4 0.62 9.9 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Ank_4 PF13637.6 PIK47733.1 - 3.9e-19 68.8 4.7 4e-13 49.6 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK47733.1 - 6.9e-15 55.4 1.9 1.7e-07 31.7 0.3 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK47733.1 - 7.4e-15 54.6 1.1 3.3e-05 24.1 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK47733.1 - 2.7e-14 53.1 4.0 3.1e-08 33.7 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK47733.1 - 3.2e-12 45.5 0.1 0.00021 21.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Hydantoinase_B PF02538.14 PIK47735.1 - 2.4e-198 659.7 1.2 3.3e-198 659.3 1.2 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 PIK47735.1 - 4.1e-108 361.0 0.0 7.7e-108 360.2 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 PIK47735.1 - 2.3e-56 190.3 0.3 2.6e-54 183.6 0.0 2.7 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region PGI PF00342.19 PIK47736.1 - 9.6e-251 832.5 0.1 1.1e-250 832.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase PASTA PF03793.19 PIK47736.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 PASTA domain Tsg PF04668.12 PIK47739.1 - 3.5e-15 56.9 0.0 6.1e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Twisted gastrulation (Tsg) protein conserved region SURNod19 PF07712.12 PIK47739.1 - 0.073 11.8 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Stress up-regulated Nod 19 Anillin PF08174.11 PIK47739.1 - 0.1 13.1 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Cell division protein anillin CREPT PF16566.5 PIK47740.1 - 9.9e-41 139.3 4.8 2.1e-27 96.1 0.4 2.8 1 1 1 2 2 2 2 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 PIK47740.1 - 2.8e-14 53.7 0.2 2.8e-14 53.7 0.2 3.0 4 0 0 4 4 4 1 RNA polymerase II-binding domain. CDPS PF16715.5 PIK47740.1 - 0.11 12.2 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 Cyclodipeptide synthase Pinin_SDK_N PF04697.13 PIK47740.1 - 0.31 11.7 7.2 3.7 8.2 0.9 2.4 2 0 0 2 2 2 0 pinin/SDK conserved region DUF16 PF01519.16 PIK47740.1 - 0.53 10.8 6.7 2 9.0 5.8 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 ApoL PF05461.11 PIK47740.1 - 0.62 9.3 3.9 1.1 8.5 3.9 1.3 1 0 0 1 1 1 0 Apolipoprotein L CTK3 PF12243.8 PIK47740.1 - 0.8 9.7 3.9 0.47 10.5 0.3 2.2 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 Swi5 PF07061.11 PIK47740.1 - 1.1 9.4 5.9 20 5.4 5.9 2.7 1 1 0 1 1 1 0 Swi5 DUF349 PF03993.12 PIK47740.1 - 3.5 8.0 8.9 1.3 9.4 0.5 3.2 4 0 0 4 4 4 0 Domain of Unknown Function (DUF349) FXR_C1 PF16096.5 PIK47740.1 - 3.9 7.8 7.9 9.1 6.6 7.9 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Spectrin PF00435.21 PIK47741.1 - 3.3e-43 146.4 57.2 6.3e-11 42.7 2.8 7.1 7 0 0 7 7 7 6 Spectrin repeat Prok-TraM PF09228.10 PIK47741.1 - 0.013 15.9 6.1 0.097 13.0 0.7 3.2 2 1 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM HECT PF00632.25 PIK47741.1 - 0.13 11.8 2.4 11 5.3 0.0 2.8 3 0 0 3 3 3 0 HECT-domain (ubiquitin-transferase) Sec20 PF03908.13 PIK47741.1 - 0.14 12.1 3.5 14 5.6 0.2 3.6 3 0 0 3 3 3 0 Sec20 PI_PP_I PF18363.1 PIK47741.1 - 0.17 12.0 18.0 0.82 9.9 0.8 5.4 5 1 0 5 5 5 0 Phosphoinositide phosphatase insertion domain BLOC1_2 PF10046.9 PIK47741.1 - 0.97 9.8 0.0 0.97 9.8 0.0 6.5 4 2 1 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 PIK47741.1 - 9.9 6.9 27.2 1.5 9.5 2.1 6.8 7 1 1 8 8 8 0 SlyX Spectrin PF00435.21 PIK47743.1 - 2.9e-07 30.9 3.5 2.9e-07 30.9 3.5 1.8 2 0 0 2 2 2 1 Spectrin repeat CLZ PF16526.5 PIK47743.1 - 0.0069 16.7 1.3 0.011 16.1 1.3 1.4 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels GrpE PF01025.19 PIK47743.1 - 0.01 15.5 2.5 0.012 15.3 2.5 1.2 1 0 0 1 1 1 0 GrpE UPF0242 PF06785.11 PIK47743.1 - 0.013 15.6 1.2 0.015 15.4 1.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus OmpH PF03938.14 PIK47743.1 - 0.019 15.3 1.1 0.024 15.0 1.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 PIK47743.1 - 0.02 14.0 0.7 0.021 13.9 0.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 PIK47743.1 - 0.03 13.9 1.1 0.039 13.5 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) MCU PF04678.13 PIK47743.1 - 0.043 13.9 0.4 0.046 13.8 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter FapA PF03961.13 PIK47743.1 - 0.06 11.9 0.2 0.066 11.8 0.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DHR10 PF18595.1 PIK47743.1 - 0.064 13.3 7.2 0.12 12.4 7.2 1.4 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain NYD-SP28 PF14772.6 PIK47743.1 - 0.61 10.2 9.0 0.7 10.0 6.4 1.9 1 1 1 2 2 2 0 Sperm tail ABC_tran_CTD PF16326.5 PIK47743.1 - 9.2 6.6 13.4 3 8.2 4.4 2.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain EF-hand_2 PF09068.11 PIK47744.1 - 4.7e-41 139.8 1.8 1e-40 138.7 1.8 1.6 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.11 PIK47744.1 - 1.9e-36 124.3 0.0 6.4e-36 122.7 0.0 2.0 1 0 0 1 1 1 1 EF-hand WW PF00397.26 PIK47744.1 - 2.6e-05 24.2 0.5 4.8e-05 23.4 0.5 1.5 1 0 0 1 1 1 1 WW domain ApoLp-III PF07464.11 PIK47744.1 - 0.056 13.5 7.5 0.16 12.0 7.5 1.9 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) BLOC1_2 PF10046.9 PIK47744.1 - 0.078 13.3 14.3 0.36 11.1 0.2 4.7 3 2 2 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 PIK47744.1 - 0.079 11.8 17.5 0.32 9.9 3.8 2.8 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF4706 PF15797.5 PIK47744.1 - 0.089 13.3 0.3 0.34 11.4 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) TPR_MLP1_2 PF07926.12 PIK47744.1 - 0.12 12.4 26.1 0.045 13.8 3.1 4.4 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF2381 PF09544.10 PIK47744.1 - 0.15 11.6 3.4 6.7 6.2 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) SOGA PF11365.8 PIK47744.1 - 0.22 12.7 20.7 0.72 11.0 3.7 3.9 2 2 1 3 3 3 0 Protein SOGA bZIP_1 PF00170.21 PIK47744.1 - 0.66 10.1 18.3 3.9 7.7 0.2 4.6 4 0 0 4 4 4 0 bZIP transcription factor Mto2_bdg PF12808.7 PIK47744.1 - 0.67 10.3 15.9 1.5 9.2 0.4 3.2 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1043 PF06295.12 PIK47744.1 - 1 9.4 10.4 1.6 8.8 5.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Jnk-SapK_ap_N PF09744.9 PIK47744.1 - 1.2 9.3 24.0 5.6 7.2 6.0 2.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 PIK47744.1 - 1.9 7.8 12.3 0.78 9.0 3.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) M PF02370.16 PIK47744.1 - 2 9.3 8.7 4.8 8.1 0.2 3.9 3 0 0 3 3 2 0 M protein repeat Spectrin PF00435.21 PIK47744.1 - 6.6 7.3 29.8 4.5 7.8 0.4 5.0 2 2 2 4 4 3 0 Spectrin repeat TSNAXIP1_N PF15739.5 PIK47744.1 - 8.7 6.8 14.7 2.8 8.3 0.6 4.1 4 1 0 5 5 4 0 Translin-associated factor X-interacting N-terminus GMC_oxred_C PF05199.13 PIK47746.1 - 6.3e-14 52.7 0.3 2e-13 51.1 0.2 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 PIK47746.1 - 3.6e-10 39.7 0.0 6.9e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Abhydrolase_6 PF12697.7 PIK47746.1 - 0.0073 16.9 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK47746.1 - 0.085 12.1 0.0 0.45 9.7 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Syja_N PF02383.18 PIK47747.1 - 7e-70 235.9 0.6 9.1e-70 235.5 0.6 1.1 1 0 0 1 1 1 1 SacI homology domain PI3K_1B_p101 PF10486.9 PIK47748.1 - 0.11 10.3 1.3 0.12 10.1 1.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Crystall_4 PF17945.1 PIK47748.1 - 0.15 12.5 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 Beta/Gamma crystallin Ank_2 PF12796.7 PIK47749.1 - 2.1e-53 178.9 4.3 1.2e-13 51.4 0.0 5.7 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK47749.1 - 1.8e-38 130.4 2.5 1e-06 29.1 0.1 8.8 5 4 3 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK47749.1 - 3.5e-36 119.1 3.9 9.6e-08 31.7 0.0 10.3 10 1 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 PIK47749.1 - 4.4e-36 121.8 11.8 1.3e-07 31.8 0.1 9.3 7 2 1 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 PIK47749.1 - 1.9e-31 107.7 0.6 1.4e-05 25.2 0.0 7.8 7 2 2 9 9 9 5 Ankyrin repeats (many copies) LRR_8 PF13855.6 PIK47750.1 - 7.2e-23 80.1 7.8 8.4e-10 38.3 0.0 4.3 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK47750.1 - 5.1e-19 68.1 17.1 0.00038 20.8 0.0 6.4 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK47750.1 - 1.1e-06 28.2 3.1 0.058 12.9 1.6 3.2 2 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK47750.1 - 4.7e-05 23.4 18.7 0.56 11.0 0.1 7.7 5 2 1 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK47750.1 - 0.0039 17.1 15.2 0.53 10.5 0.1 6.9 8 0 0 8 8 8 2 Leucine Rich repeat Roc PF08477.13 PIK47751.1 - 4.1e-25 88.3 0.1 4.7e-20 72.0 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK47751.1 - 1e-14 54.5 0.1 6.8e-12 45.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Arf PF00025.21 PIK47751.1 - 1.2e-06 28.1 0.1 0.015 14.7 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family LRR_4 PF12799.7 PIK47751.1 - 0.00012 22.4 0.6 0.00039 20.7 0.6 1.9 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK47751.1 - 0.00037 20.2 0.1 0.0011 18.7 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat TniB PF05621.11 PIK47751.1 - 0.0027 17.2 0.0 0.0058 16.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein RsgA_GTPase PF03193.16 PIK47751.1 - 0.012 15.5 0.0 0.042 13.7 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 PIK47751.1 - 0.013 14.7 0.0 0.091 11.9 0.0 2.3 3 0 0 3 3 3 0 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK47751.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 PIK47751.1 - 0.025 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK47751.1 - 0.027 14.9 0.0 0.047 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 PIK47751.1 - 0.034 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 PIK47751.1 - 0.045 13.3 0.3 0.7 9.4 0.0 2.4 3 0 0 3 3 3 0 Ferrous iron transport protein B GTP_EFTU PF00009.27 PIK47751.1 - 0.045 13.3 0.0 0.079 12.5 0.0 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK47751.1 - 0.049 13.0 0.1 0.39 10.0 0.0 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Septin PF00735.18 PIK47751.1 - 0.052 12.8 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Septin SRPRB PF09439.10 PIK47751.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Pkinase PF00069.25 PIK47752.1 - 3.1e-42 144.8 0.0 6.2e-41 140.5 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47752.1 - 1.8e-40 138.8 0.0 5.1e-35 121.0 0.0 2.7 2 0 0 2 2 2 2 Protein tyrosine kinase COR PF16095.5 PIK47752.1 - 1.9e-17 63.7 0.4 1.1e-16 61.3 0.0 2.1 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain RWD PF05773.22 PIK47753.1 - 5.7e-16 58.8 0.3 5.7e-16 58.8 0.3 1.8 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 PIK47753.1 - 5.7e-06 26.7 5.0 5.7e-06 26.7 5.0 2.0 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 MCM3AP_GANP PF16769.5 PIK47753.1 - 0.018 13.4 4.6 0.022 13.1 4.6 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP DUF445 PF04286.12 PIK47753.1 - 0.061 13.1 4.4 0.078 12.8 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF4317 PF14199.6 PIK47753.1 - 0.066 12.4 5.7 0.084 12.0 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) MIEAP PF16026.5 PIK47753.1 - 0.25 11.5 2.0 1.6 8.9 0.6 2.0 1 1 1 2 2 2 0 Mitochondria-eating protein Enkurin PF13864.6 PIK47753.1 - 6.6 7.2 13.6 25 5.4 8.0 2.8 1 1 1 2 2 2 0 Calmodulin-binding HgmA PF04209.13 PIK47754.1 - 1e-196 653.7 0.2 1.2e-196 653.5 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase End_tail_spike PF12219.8 PIK47754.1 - 0.028 14.5 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Catalytic domain of bacteriophage endosialidase Ferric_reduct PF01794.19 PIK47755.1 - 2.5e-16 59.9 9.1 4.5e-16 59.1 9.1 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 PIK47755.1 - 1.6e-13 50.7 0.0 4.2e-13 49.3 0.0 1.7 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 PIK47755.1 - 2.5e-10 40.7 0.0 1.5e-09 38.2 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 PIK47755.1 - 0.055 14.1 0.0 0.097 13.3 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Toxin_20 PF08089.11 PIK47755.1 - 4 7.6 6.7 0.19 11.9 1.0 1.8 2 0 0 2 2 2 0 Huwentoxin-II family BEN PF10523.9 PIK47756.1 - 2.6e-10 40.4 0.0 4.9e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 BEN domain Fibrinogen_C PF00147.18 PIK47757.1 - 4.5e-39 134.5 0.3 5.3e-39 134.3 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47758.1 - 2.3e-43 148.6 0.5 2.8e-43 148.3 0.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47759.1 - 1.8e-26 93.3 8.8 4.2e-19 69.2 4.8 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK47759.1 - 0.88 9.5 6.0 0.86 9.5 0.5 2.4 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) Fibrinogen_C PF00147.18 PIK47760.1 - 2.3e-43 148.6 0.4 2.8e-43 148.3 0.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47761.1 - 1.1e-43 149.6 0.4 1.4e-43 149.3 0.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47762.1 - 3.5e-35 121.8 1.1 4.8e-26 91.9 0.2 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47763.1 - 2.2e-43 148.6 0.5 2.7e-43 148.4 0.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47764.1 - 3.1e-36 125.3 0.3 3.9e-36 124.9 0.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK47765.1 - 2e-13 50.1 14.4 5.7e-07 29.4 3.1 2.5 2 0 0 2 2 2 2 TILa domain EGF_3 PF12947.7 PIK47765.1 - 1.3e-09 38.1 40.0 9.2e-06 25.8 8.7 4.2 2 2 2 4 4 4 2 EGF domain Fibrinogen_C PF00147.18 PIK47765.1 - 1.5e-09 38.0 0.8 2.5e-09 37.3 0.1 1.7 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 PIK47765.1 - 9.6e-06 25.9 27.7 0.0055 17.0 9.7 3.3 2 2 0 2 2 2 2 EGF-like domain EGF_MSP1_1 PF12946.7 PIK47765.1 - 2.7e-05 24.1 23.4 0.0016 18.4 3.6 3.1 3 0 0 3 3 3 2 MSP1 EGF domain 1 Caprin-1_C PF12287.8 PIK47765.1 - 0.079 13.1 3.8 0.41 10.8 0.7 2.1 1 1 1 2 2 2 0 Cytoplasmic activation/proliferation-associated protein-1 C term Fibrinogen_C PF00147.18 PIK47766.1 - 1.9e-10 40.9 0.1 1.9e-10 40.9 0.1 1.7 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK47766.1 - 1.3e-06 28.5 9.9 1.3e-06 28.5 9.9 3.9 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK47766.1 - 3.4e-05 23.7 5.7 3.4e-05 23.7 5.7 3.1 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK47766.1 - 0.0069 16.6 13.8 0.0069 16.6 13.8 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK47766.1 - 0.23 11.8 29.3 0.093 13.1 10.3 4.3 3 2 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK47767.1 - 2.5e-43 148.4 0.3 3.2e-43 148.1 0.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47768.1 - 3e-19 69.7 5.1 3.3e-19 69.6 5.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK47769.1 - 5e-23 82.1 1.0 5.5e-23 81.9 1.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COesterase PF00135.28 PIK47770.1 - 1.7e-29 103.1 0.0 1.8e-29 103.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK47771.1 - 7e-137 457.4 0.0 8.4e-137 457.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK47771.1 - 9e-10 38.8 0.2 5e-09 36.3 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK47771.1 - 0.0033 16.9 0.3 0.0061 16.1 0.3 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK47771.1 - 0.049 12.5 0.0 0.089 11.6 0.0 1.4 1 0 0 1 1 1 0 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 PIK47771.1 - 0.19 12.3 1.6 0.37 11.4 1.6 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family COesterase PF00135.28 PIK47772.1 - 1e-58 199.5 0.6 1.3e-39 136.5 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family AChE_tetra PF08674.10 PIK47772.1 - 0.27 11.0 9.3 0.048 13.3 3.4 2.6 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain Peptidase_M2 PF01401.18 PIK47773.1 - 1e-167 559.2 0.0 1.3e-167 558.9 0.0 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Peptidase_M2 PF01401.18 PIK47774.1 - 5.6e-86 289.4 0.0 2.9e-48 164.9 0.0 2.0 1 1 1 2 2 2 2 Angiotensin-converting enzyme DUF2250 PF10007.9 PIK47774.1 - 0.22 11.7 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) RVT_1 PF00078.27 PIK47775.1 - 1.5e-07 31.2 0.2 3.9e-07 29.8 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK47775.1 - 2.8e-05 24.3 0.0 0.00021 21.5 0.0 2.3 2 0 0 2 2 2 1 GIY-YIG catalytic domain Ferrochelatase PF00762.19 PIK47776.1 - 4.3e-110 367.7 0.0 5e-110 367.5 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Hemopexin PF00045.19 PIK47777.1 - 1.6e-101 332.0 33.8 5.6e-15 55.0 0.1 11.1 11 0 0 11 11 11 11 Hemopexin Sulfotransfer_2 PF03567.14 PIK47778.1 - 1.4e-09 38.2 0.0 3.8e-09 36.8 0.0 1.6 1 1 1 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK47778.1 - 0.015 14.8 0.1 0.25 10.8 0.1 2.2 1 1 0 1 1 1 0 Sulfotransferase domain PsbL PF02419.17 PIK47778.1 - 0.29 11.2 2.9 23 5.1 0.7 2.8 3 0 0 3 3 3 0 PsbL protein DUF1759 PF03564.15 PIK47780.1 - 7.3e-07 29.2 0.1 1.6e-06 28.2 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF4841 PF16129.5 PIK47780.1 - 0.02 15.2 0.2 0.52 10.6 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4841) Fasciclin PF02469.22 PIK47781.1 - 1.2e-25 90.2 0.9 1.5e-20 73.7 0.6 2.3 2 1 0 2 2 2 2 Fasciclin domain TetR_C_37 PF18665.1 PIK47781.1 - 0.082 13.5 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain UPF0047 PF01894.17 PIK47781.1 - 0.11 12.6 0.1 0.17 12.1 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0047 RVT_1 PF00078.27 PIK47782.1 - 2.6e-23 82.7 0.0 3.1e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Collagen PF01391.18 PIK47783.1 - 0.2 11.5 4.2 0.31 10.8 4.2 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) F-box PF00646.33 PIK47783.1 - 0.31 11.0 1.1 1 9.3 0.2 2.1 2 0 0 2 2 2 0 F-box domain Vps5 PF09325.10 PIK47785.1 - 3.4e-05 23.5 10.2 0.0083 15.7 0.8 2.2 1 1 1 2 2 2 2 Vps5 C terminal like GrpE PF01025.19 PIK47785.1 - 0.022 14.4 1.2 0.022 14.4 1.2 2.1 2 0 0 2 2 2 0 GrpE PhaP_Bmeg PF09602.10 PIK47785.1 - 0.15 12.0 5.2 0.1 12.5 0.9 2.3 2 1 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) GREB1 PF15782.5 PIK47786.1 - 4.7 4.2 33.7 6.4 3.8 33.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NACHT PF05729.12 PIK47788.1 - 3e-06 27.2 0.0 8.2e-06 25.8 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK47788.1 - 0.0077 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK47788.1 - 0.072 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Pkinase_Tyr PF07714.17 PIK47789.1 - 1.2e-09 37.9 0.1 1.4e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47789.1 - 9.8e-08 31.7 0.0 1.1e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK47790.1 - 1.2e-18 66.9 5.5 6.9e-07 29.3 0.1 3.4 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK47790.1 - 1.4e-09 38.4 9.0 0.014 15.9 0.3 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK47790.1 - 4.2e-08 33.4 7.7 0.045 14.1 0.1 4.5 4 0 0 4 4 4 3 Immunoglobulin domain C1-set PF07654.15 PIK47790.1 - 1e-07 32.3 2.1 0.14 12.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin C1-set domain I-set PF07679.16 PIK47790.1 - 0.0093 16.0 1.8 2.9 8.0 0.0 4.0 5 0 0 5 5 5 1 Immunoglobulin I-set domain ig PF00047.25 PIK47790.1 - 0.066 13.4 5.8 3.8 7.7 0.1 4.1 4 0 0 4 4 4 0 Immunoglobulin domain DUF4307 PF14155.6 PIK47790.1 - 0.069 13.0 3.1 0.34 10.7 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4307) YccF PF03733.13 PIK47790.1 - 9.9 7.0 9.0 0.44 11.3 2.1 2.4 2 0 0 2 2 2 0 Inner membrane component domain NACHT PF05729.12 PIK47792.1 - 4.4e-10 39.7 0.0 1e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK47792.1 - 0.00021 20.9 0.0 0.0089 15.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 PIK47792.1 - 0.011 16.0 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain V-set PF07686.17 PIK47792.1 - 0.052 13.7 0.2 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK47792.1 - 0.054 14.1 0.7 5.5 7.7 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK47792.1 - 0.16 12.4 0.3 18 5.8 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin domain NACHT PF05729.12 PIK47793.1 - 1.6e-13 50.9 0.0 8.7e-13 48.5 0.0 2.2 2 0 0 2 2 2 1 NACHT domain Ig_2 PF13895.6 PIK47793.1 - 1e-07 32.2 5.6 0.058 13.7 0.1 4.9 3 2 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK47793.1 - 6.5e-06 26.7 9.3 7.8 7.2 0.0 5.6 3 2 1 4 4 4 2 Immunoglobulin domain MAP17 PF15807.5 PIK47793.1 - 0.00012 22.3 0.0 0.00032 20.9 0.0 1.6 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 C2-set_2 PF08205.12 PIK47793.1 - 0.00048 20.1 4.2 0.4 10.8 0.2 3.0 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Marek_A PF02124.15 PIK47793.1 - 0.0015 18.4 0.3 0.0015 18.4 0.3 2.4 2 1 0 2 2 2 1 Marek's disease glycoprotein A V-set PF07686.17 PIK47793.1 - 0.0099 16.0 5.8 0.11 12.6 0.0 3.6 4 1 0 4 4 4 1 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK47793.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain CobA_CobO_BtuR PF02572.15 PIK47793.1 - 0.058 13.7 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP ig PF00047.25 PIK47793.1 - 3.3 8.0 8.6 22 5.3 0.2 4.4 3 1 1 4 4 4 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK47794.1 - 4e-20 72.2 0.0 2.5e-19 69.6 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK47794.1 - 2e-09 37.2 0.0 3.8e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK47794.1 - 2.6e-08 34.3 0.2 0.38 11.4 0.0 3.6 2 1 1 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK47794.1 - 3.8e-07 30.2 0.2 0.71 10.1 0.1 3.6 2 1 1 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK47794.1 - 3.1e-06 27.4 0.6 0.25 11.7 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK47794.1 - 0.0018 18.3 0.0 0.41 10.7 0.0 2.6 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK47794.1 - 0.05 13.8 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin V-set domain DUF2090 PF09863.9 PIK47794.1 - 0.098 11.7 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) NACHT PF05729.12 PIK47795.1 - 7.5e-06 26.0 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF4248 PF14053.6 PIK47795.1 - 0.049 13.7 0.0 0.23 11.5 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) C2-set_2 PF08205.12 PIK47796.1 - 1.3e-07 31.5 2.7 0.0029 17.6 0.5 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK47796.1 - 4.3e-06 26.8 0.3 0.0013 18.9 0.1 2.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK47796.1 - 6.5e-06 26.7 3.6 0.83 10.3 0.0 4.5 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK47796.1 - 0.00026 21.3 0.5 1.6 9.1 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK47796.1 - 0.023 14.8 1.4 0.6 10.2 0.0 3.4 3 1 1 4 4 4 0 Immunoglobulin I-set domain ODV-E18 PF10717.9 PIK47796.1 - 0.1 12.5 0.4 0.28 11.1 0.4 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ig PF00047.25 PIK47796.1 - 0.47 10.7 4.2 22 5.3 0.0 3.9 3 1 0 3 3 3 0 Immunoglobulin domain Presenilin PF01080.17 PIK47797.1 - 3.1 6.5 6.6 4.1 6.1 6.6 1.1 1 0 0 1 1 1 0 Presenilin RVT_1 PF00078.27 PIK47798.1 - 0.0014 18.2 1.2 0.0065 16.0 0.1 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK47799.1 - 2.6e-13 50.2 0.0 6.4e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK47799.1 - 2.4e-09 37.6 6.1 0.0002 21.9 0.1 4.7 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK47799.1 - 1.4e-07 31.6 0.2 2.4e-05 24.5 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK47799.1 - 4.8e-07 29.9 1.0 0.00087 19.4 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK47799.1 - 6.2e-06 26.5 2.4 0.019 15.3 0.0 4.7 4 1 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK47799.1 - 9.4e-06 25.6 0.6 0.06 13.4 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin I-set domain TMEM154 PF15102.6 PIK47799.1 - 2.8e-05 24.0 0.3 7.9e-05 22.6 0.3 1.7 1 0 0 1 1 1 1 TMEM154 protein family C2-set_2 PF08205.12 PIK47799.1 - 6.9e-05 22.8 2.8 0.49 10.5 0.1 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Cadherin_C_2 PF16492.5 PIK47799.1 - 0.0016 19.1 0.1 0.0062 17.3 0.1 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal NB-ARC PF00931.22 PIK47799.1 - 0.0019 17.4 0.0 0.0038 16.4 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TgMIC1 PF11476.8 PIK47799.1 - 0.012 15.3 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 AAA_25 PF13481.6 PIK47799.1 - 0.04 13.5 0.0 0.098 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF5527 PF17665.1 PIK47799.1 - 0.064 12.8 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Orf78 PF06024.12 PIK47799.1 - 0.12 12.6 5.0 0.51 10.7 0.1 3.3 3 0 0 3 3 3 0 Orf78 (ac78) Ig_5 PF16681.5 PIK47799.1 - 0.44 11.0 2.5 1.1 9.7 0.2 2.9 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain RVT_1 PF00078.27 PIK47800.1 - 1.7e-06 27.7 0.3 3.9e-06 26.5 0.0 1.7 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2498 PF10692.9 PIK47800.1 - 0.073 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) DUF2095 PF09868.9 PIK47801.1 - 0.0066 16.4 0.0 0.021 14.8 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2095) DED PF01335.21 PIK47801.1 - 0.023 15.0 0.2 0.094 13.0 0.2 2.0 1 0 0 1 1 1 0 Death effector domain MULE PF10551.9 PIK47802.1 - 6.8e-18 64.9 0.1 1.3e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain TIR PF01582.20 PIK47802.1 - 0.034 14.0 0.3 0.072 12.9 0.3 1.6 1 0 0 1 1 1 0 TIR domain HTH_Tnp_4 PF13613.6 PIK47802.1 - 0.11 12.2 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HD PF01966.22 PIK47803.1 - 7.1e-16 58.5 0.1 2.6e-15 56.7 0.1 2.0 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 PIK47803.1 - 0.0027 17.4 0.1 0.0061 16.3 0.1 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF1967 PF09269.11 PIK47803.1 - 0.088 12.8 0.1 0.29 11.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) YchF-GTPase_C PF06071.13 PIK47803.1 - 0.1 12.8 0.0 0.44 10.8 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF933) ssDBP_DBD PF18361.1 PIK47803.1 - 0.12 12.5 0.2 0.34 11.1 0.1 1.8 2 0 0 2 2 2 0 Single stranded DNA-binding protein ss DNA binding domain HD PF01966.22 PIK47805.1 - 2.3e-07 31.1 0.0 3.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 HD domain Neur_chan_memb PF02932.16 PIK47806.1 - 6e-42 144.3 0.1 1e-41 143.6 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK47806.1 - 3.3e-06 26.7 0.0 5.8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Zip PF02535.22 PIK47806.1 - 0.059 12.6 0.1 0.085 12.1 0.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Lig_chan PF00060.26 PIK47807.1 - 3.9e-43 146.9 0.0 5.1e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK47807.1 - 3.3e-19 69.2 0.3 6.1e-19 68.3 0.3 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 PIK47807.1 - 1.7e-08 34.2 0.0 5.5e-06 26.0 0.0 2.4 2 1 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 PIK47807.1 - 0.0023 17.8 0.4 0.0023 17.8 0.4 1.7 2 0 0 2 2 2 1 Ion channel 7tm_3 PF00003.22 PIK47808.1 - 2.4e-33 115.9 14.2 2.9e-25 89.4 4.8 2.2 1 1 1 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 PIK47808.1 - 0.00043 19.5 0.0 0.00075 18.7 0.0 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region DUF1418 PF07214.12 PIK47808.1 - 0.058 13.2 0.0 0.058 13.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1418) DUF5453 PF17534.2 PIK47808.1 - 0.38 10.7 8.5 1.9 8.4 5.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5453) GIT_CC PF16559.5 PIK47808.1 - 4.9 7.1 5.5 1.9 8.4 0.4 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PGK PF00162.19 PIK47809.1 - 2.6e-23 82.6 1.9 9.5e-15 54.4 1.2 2.2 1 1 0 2 2 2 2 Phosphoglycerate kinase PGK PF00162.19 PIK47810.1 - 2.4e-85 286.8 0.5 2.9e-85 286.5 0.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Bac_A_amyl_C PF18612.1 PIK47811.1 - 8.4 6.2 9.1 9.6 6.1 0.3 3.0 1 1 2 3 3 3 0 Bacterial Alpha amylase C-terminal domain RmlD_sub_bind PF04321.17 PIK47812.1 - 8.5e-61 205.5 0.0 9.7e-61 205.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 PIK47812.1 - 9.3e-22 77.7 0.0 1.7e-21 76.8 0.0 1.5 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK47812.1 - 7.8e-12 44.9 0.3 3e-09 36.5 0.3 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK47812.1 - 3.2e-11 43.2 0.0 1.7e-10 40.8 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK47812.1 - 5.8e-08 32.2 0.0 1.1e-05 24.7 0.0 2.5 2 1 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 PIK47812.1 - 5.3e-07 28.9 0.2 2.7e-06 26.6 0.2 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 PIK47812.1 - 0.00047 19.7 0.0 0.0021 17.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase DapB_N PF01113.20 PIK47812.1 - 0.0022 18.1 0.0 0.0042 17.2 0.0 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 PIK47812.1 - 0.022 14.6 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 PIK47812.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family SNF PF00209.18 PIK47813.1 - 3.6e-184 613.3 30.2 4.4e-184 613.0 30.2 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Patatin PF01734.22 PIK47814.1 - 1.1e-10 42.1 0.0 1.7e-09 38.1 0.0 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase RVT_1 PF00078.27 PIK47815.1 - 7.6e-08 32.1 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK47815.1 - 0.015 15.6 0.0 0.078 13.3 0.0 2.2 2 1 0 2 2 2 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK47815.1 - 0.016 15.7 0.0 0.045 14.3 0.0 1.8 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease PriCT_1 PF08708.11 PIK47815.1 - 0.068 12.9 0.0 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Primase C terminal 1 (PriCT-1) rve PF00665.26 PIK47816.1 - 8.4e-21 74.4 0.0 1.2e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK47816.1 - 1.2e-19 70.1 0.2 2.3e-19 69.3 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK47816.1 - 5.4e-06 26.5 0.0 1.5e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK47816.1 - 0.0028 17.4 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK47816.1 - 0.017 15.4 0.0 0.026 14.7 0.0 1.2 1 0 0 1 1 1 0 DDE domain gag_pre-integrs PF13976.6 PIK47816.1 - 0.06 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain DUF4042 PF13251.6 PIK47816.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4042) RT_RNaseH_2 PF17919.1 PIK47817.1 - 1.9e-29 101.6 0.0 4.1e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47817.1 - 7.2e-29 100.9 0.0 1.4e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK47817.1 - 2.2e-27 95.4 0.0 4.6e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK47817.1 - 6.3e-20 71.6 0.0 1.5e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK47817.1 - 5.6e-17 61.6 0.7 5.6e-17 61.6 0.7 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK47817.1 - 0.0042 16.8 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK47817.1 - 0.0053 16.9 0.2 0.0053 16.9 0.2 2.2 3 0 0 3 3 3 1 H2C2 zinc finger RVT_thumb PF06817.14 PIK47817.1 - 0.052 13.4 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase thumb domain UBA_5 PF16577.5 PIK47818.1 - 4.3e-15 55.6 0.2 1.2e-14 54.1 0.0 1.8 2 0 0 2 2 2 1 UBA domain ZZ PF00569.17 PIK47818.1 - 9.4e-11 41.4 5.3 9.4e-11 41.4 5.3 1.8 2 0 0 2 2 2 1 Zinc finger, ZZ type PB1 PF00564.24 PIK47818.1 - 5.4e-09 35.9 0.0 9.4e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 PB1 domain zf-UBR PF02207.20 PIK47818.1 - 0.1 12.8 5.2 0.22 11.7 5.2 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) YkuI_C PF10388.9 PIK47818.1 - 0.16 11.7 0.4 0.62 9.9 0.0 1.9 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain UBA2_C PF16195.5 PIK47818.1 - 0.18 12.5 8.2 0.47 11.2 8.2 1.7 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus C1_2 PF03107.16 PIK47818.1 - 1.5 9.2 6.9 3 8.2 6.9 1.5 1 0 0 1 1 1 0 C1 domain 7tm_1 PF00001.21 PIK47819.1 - 2.8e-36 125.2 19.9 3.6e-36 124.8 19.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK47819.1 - 4.7e-07 29.5 18.5 6e-07 29.1 18.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK47819.1 - 5.6e-05 23.0 11.1 5.6e-05 23.0 11.1 1.7 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK47819.1 - 0.0009 18.9 17.2 0.0009 18.9 17.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TPR_12 PF13424.6 PIK47820.1 - 6.1e-26 90.5 12.2 1.7e-08 34.6 2.6 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK47820.1 - 5.1e-14 51.4 11.7 0.0038 17.0 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK47820.1 - 9.4e-14 50.4 13.4 0.016 15.4 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK47820.1 - 1.1e-11 43.9 9.2 0.016 15.2 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK47820.1 - 1.2e-11 43.8 16.4 0.021 14.9 0.2 5.2 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 PIK47820.1 - 2e-09 37.4 7.3 0.0038 17.8 0.6 5.3 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK47820.1 - 7.7e-09 35.4 1.8 3.9e-07 29.8 0.3 2.5 1 1 0 2 2 2 1 MalT-like TPR region RPN7 PF10602.9 PIK47820.1 - 3.6e-07 30.1 10.0 0.0053 16.5 0.2 4.1 2 2 2 4 4 4 2 26S proteasome subunit RPN7 TPR_14 PF13428.6 PIK47820.1 - 5.1e-07 30.0 9.6 0.28 12.1 0.2 5.2 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK47820.1 - 3.9e-06 26.9 4.7 0.014 15.5 0.3 3.6 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK47820.1 - 7.8e-06 26.5 7.2 0.084 13.5 0.8 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK47820.1 - 0.00079 19.4 3.7 0.059 13.5 1.8 3.4 2 1 0 2 2 1 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 PIK47820.1 - 0.0018 18.1 5.5 0.56 10.2 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK47820.1 - 0.0026 18.0 10.9 0.034 14.4 5.2 4.0 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK47820.1 - 0.0027 18.2 2.4 0.12 12.9 0.6 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK47820.1 - 0.0043 17.3 1.8 19 5.9 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK47820.1 - 0.0052 16.4 2.8 13 5.5 0.0 4.5 4 0 0 4 4 4 0 TPR repeat ArnB_C PF18677.1 PIK47820.1 - 0.01 15.9 2.3 3.4 7.9 0.1 3.4 3 0 0 3 3 3 0 Archaellum regulatory network B, C-terminal domain Foie-gras_1 PF11817.8 PIK47820.1 - 0.021 14.4 3.0 0.32 10.5 0.3 3.2 1 1 2 3 3 3 0 Foie gras liver health family 1 TPR_20 PF14561.6 PIK47820.1 - 0.022 15.1 0.5 1.8 9.0 0.0 3.3 2 1 1 3 3 2 0 Tetratricopeptide repeat Clathrin PF00637.20 PIK47820.1 - 0.039 13.8 1.6 2.6 7.9 0.1 2.7 2 1 0 2 2 2 0 Region in Clathrin and VPS PPR PF01535.20 PIK47820.1 - 0.19 12.1 3.2 6.9 7.2 0.2 3.9 3 0 0 3 3 3 0 PPR repeat TPR_4 PF07721.14 PIK47820.1 - 0.26 12.0 5.9 20 6.1 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Sec3_C PF09763.9 PIK47821.1 - 4.1e-125 418.8 26.2 8.7e-95 318.6 19.0 3.1 2 1 0 2 2 2 2 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 PIK47821.1 - 3.9e-22 78.2 0.9 3.9e-22 78.2 0.9 2.3 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Snapin_Pallidin PF14712.6 PIK47821.1 - 0.00027 21.3 11.1 0.0018 18.7 3.1 3.1 1 1 0 2 2 2 2 Snapin/Pallidin Acyl_transf_1 PF00698.21 PIK47822.1 - 8.9e-57 193.0 0.0 1.7e-56 192.1 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 PIK47822.1 - 1.1e-48 165.5 0.0 2.4e-48 164.4 0.0 1.6 1 0 0 1 1 1 1 KR domain Thioesterase PF00975.20 PIK47822.1 - 2.2e-23 83.6 0.0 5.5e-23 82.3 0.0 1.8 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.6 PIK47822.1 - 4.7e-17 62.2 0.0 8.7e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 PIK47822.1 - 7.6e-09 35.3 0.1 2.4e-06 27.1 0.0 2.9 3 0 0 3 3 3 2 short chain dehydrogenase PP-binding PF00550.25 PIK47822.1 - 5.7e-08 33.0 0.3 1.2e-07 31.9 0.3 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.6 PIK47822.1 - 0.00023 22.2 0.0 0.00068 20.7 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 PIK47822.1 - 0.00037 20.5 0.0 0.001 19.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Abhydrolase_6 PF12697.7 PIK47822.1 - 0.014 16.0 0.0 0.7 10.5 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family ketoacyl-synt PF00109.26 PIK47823.1 - 1.1e-64 218.4 0.0 1.7e-64 217.8 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 PIK47823.1 - 1.3e-39 134.8 0.0 3.2e-39 133.6 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 PIK47823.1 - 1.5e-29 102.7 0.0 3.1e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 PIK47823.1 - 1.9e-08 34.2 0.0 3.4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.23 PIK47823.1 - 0.00063 19.2 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain RRM_1 PF00076.22 PIK47824.1 - 0.0027 17.5 0.2 0.01 15.7 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 PIK47825.1 - 1.7e-11 43.7 16.8 2.1e-11 43.3 16.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK47825.1 - 1.8e-05 23.5 5.8 2.5e-05 23.1 5.8 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Beta-lactamase PF00144.24 PIK47826.1 - 1.3e-40 139.6 0.0 5.5e-26 91.6 0.0 2.0 2 0 0 2 2 2 2 Beta-lactamase Peptidase_S11 PF00768.20 PIK47826.1 - 0.05 13.0 0.2 0.16 11.3 0.1 1.9 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Aconitase PF00330.20 PIK47827.1 - 3.4e-70 237.3 0.0 4.5e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 PIK47827.1 - 3.4e-45 153.6 0.0 4.2e-43 146.8 0.0 2.9 3 0 0 3 3 3 1 Aconitase C-terminal domain CSD2 PF17876.1 PIK47827.1 - 0.0092 16.1 0.0 0.33 11.2 0.0 3.0 3 0 0 3 3 3 1 Cold shock domain RVT_1 PF00078.27 PIK47829.1 - 2.1e-09 37.2 0.1 2.6e-06 27.1 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4704 PF15787.5 PIK47829.1 - 0.039 13.2 0.0 0.085 12.1 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4704) Raftlin PF15250.6 PIK47829.1 - 0.18 10.5 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Raftlin Med14 PF08638.11 PIK47830.1 - 6.2e-63 211.7 0.2 1e-62 211.0 0.2 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Glyco_transf_10 PF00852.19 PIK47832.1 - 1e-51 175.1 0.3 1.3e-51 174.9 0.3 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Rhomboid PF01694.22 PIK47833.1 - 4.6e-24 85.1 5.0 4.6e-24 85.1 5.0 1.4 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 PIK47833.1 - 0.0012 19.4 1.2 0.0012 19.4 1.2 2.0 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Kelch_1 PF01344.25 PIK47834.1 - 5.8e-33 112.2 18.4 2e-12 46.5 0.1 7.2 8 1 0 8 8 8 3 Kelch motif Kelch_6 PF13964.6 PIK47834.1 - 4.1e-25 87.2 9.2 3.3e-10 39.9 0.0 5.8 3 3 2 5 5 5 3 Kelch motif Kelch_4 PF13418.6 PIK47834.1 - 8.5e-19 67.3 4.4 3.5e-07 30.1 0.1 4.6 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK47834.1 - 1.9e-17 63.1 3.7 4.8e-08 33.1 0.1 4.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK47834.1 - 8.2e-16 57.3 5.6 2.5e-05 24.0 0.0 5.0 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 PIK47834.1 - 5.6e-12 45.4 6.8 0.00024 21.0 0.0 4.5 6 0 0 6 6 6 3 Kelch motif PQQ_3 PF13570.6 PIK47834.1 - 0.035 14.6 7.1 0.2 12.2 0.5 4.3 5 0 0 5 5 5 0 PQQ-like domain Pepsin-I3 PF06394.13 PIK47834.1 - 0.35 11.1 0.8 25 5.1 0.0 3.1 3 0 0 3 3 3 0 Pepsin inhibitor-3-like repeated domain BTB PF00651.31 PIK47835.1 - 7.8e-42 142.0 1.6 4.1e-27 94.6 0.7 2.3 2 0 0 2 2 2 2 BTB/POZ domain DUF3342 PF11822.8 PIK47835.1 - 5.3e-07 29.7 0.1 1.4e-05 25.2 0.1 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) BACK PF07707.15 PIK47835.1 - 8.3e-06 25.8 2.1 1.4e-05 25.1 0.6 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Skp1_POZ PF03931.15 PIK47835.1 - 0.13 12.4 0.0 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain UBA_4 PF14555.6 PIK47836.1 - 2.4e-09 36.9 0.0 5e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain Ion_trans PF00520.31 PIK47837.1 - 8.8e-51 172.5 5.0 1.2e-50 172.0 5.0 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 PIK47837.1 - 1.3e-26 92.8 0.0 2.3e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 PIK47837.1 - 1.6e-13 50.4 2.2 1.6e-13 50.4 2.2 2.6 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 PIK47837.1 - 0.0027 16.4 4.1 0.014 14.1 4.1 1.9 1 1 0 1 1 1 1 Polycystin cation channel zf-NOSIP PF15906.5 PIK47838.1 - 1.5e-26 92.4 0.0 3e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 PIK47838.1 - 3.3e-09 36.8 0.3 0.0028 17.8 0.0 3.1 3 0 0 3 3 3 2 U-box domain Rtf2 PF04641.12 PIK47838.1 - 5.9e-08 32.4 3.2 2.1e-05 24.0 0.4 3.2 2 2 1 3 3 3 2 Rtf2 RING-finger zf-Nse PF11789.8 PIK47838.1 - 0.0043 16.9 0.5 0.042 13.7 0.1 2.7 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit Phage_Gp23 PF10669.9 PIK47838.1 - 0.013 15.8 3.8 0.023 15.0 3.8 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) BBS2_C PF14782.6 PIK47838.1 - 0.43 9.3 4.2 0.68 8.6 3.6 1.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal KASH_CCD PF14662.6 PIK47839.1 - 1.4e-06 28.3 30.1 7.2e-05 22.7 16.3 2.2 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH Microtub_bd PF16796.5 PIK47839.1 - 0.00025 21.0 1.5 0.38 10.7 0.6 2.7 2 0 0 2 2 2 2 Microtubule binding Myosin_tail_1 PF01576.19 PIK47839.1 - 0.00026 19.0 29.1 0.00038 18.4 29.1 1.1 1 0 0 1 1 1 1 Myosin tail DUF812 PF05667.11 PIK47839.1 - 0.00044 19.3 18.5 0.00055 18.9 18.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) BRE1 PF08647.11 PIK47839.1 - 0.0011 18.9 27.0 0.07 13.2 6.0 3.2 1 1 2 3 3 3 2 BRE1 E3 ubiquitin ligase MPS2 PF17060.5 PIK47839.1 - 0.0018 17.6 12.3 0.0018 17.6 12.3 2.3 1 1 1 2 2 2 1 Monopolar spindle protein 2 MAD PF05557.13 PIK47839.1 - 0.0025 16.3 20.3 0.0025 16.3 20.3 2.0 1 1 1 2 2 2 1 Mitotic checkpoint protein Atg14 PF10186.9 PIK47839.1 - 0.018 14.2 24.2 3 6.9 24.2 2.1 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DNAPolymera_Pol PF11590.8 PIK47839.1 - 0.032 14.1 1.4 0.18 11.7 0.3 2.3 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol Fez1 PF06818.15 PIK47839.1 - 0.039 14.4 28.9 2.5 8.5 9.5 2.2 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 PIK47839.1 - 0.071 13.3 34.3 0.98 9.6 11.4 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Bacillus_HBL PF05791.11 PIK47839.1 - 0.1 12.4 11.6 1.4 8.7 3.7 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Bacteriocin_IIi PF11758.8 PIK47839.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin BST2 PF16716.5 PIK47839.1 - 0.1 13.2 27.5 0.24 12.0 7.9 3.8 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 AAA_13 PF13166.6 PIK47839.1 - 0.11 11.1 23.3 0.22 10.1 23.3 1.4 1 1 0 1 1 1 0 AAA domain Succ_DH_flav_C PF02910.20 PIK47839.1 - 0.16 11.9 5.8 0.19 11.7 4.3 1.8 1 1 0 1 1 1 0 Fumarate reductase flavoprotein C-term YtxH PF12732.7 PIK47839.1 - 0.3 11.7 6.6 1.2 9.7 0.9 3.3 1 1 1 2 2 2 0 YtxH-like protein Goodbye PF17109.5 PIK47839.1 - 0.36 11.3 5.8 6.3 7.3 1.0 2.6 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain DUF1664 PF07889.12 PIK47839.1 - 0.39 10.8 19.7 0.14 12.2 7.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 PIK47839.1 - 0.45 10.5 18.9 0.77 9.8 11.2 2.9 1 1 1 2 2 2 0 Laminin Domain II DUF5320 PF17253.2 PIK47839.1 - 0.48 11.5 0.1 0.48 11.5 0.1 3.4 2 1 0 2 2 1 0 Family of unknown function (DUF5320) DUF4407 PF14362.6 PIK47839.1 - 0.49 9.7 18.2 1.6 8.0 17.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 PIK47839.1 - 0.61 10.1 9.2 0.79 9.8 5.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5631 PF18645.1 PIK47839.1 - 0.69 10.3 2.4 1.8 9.0 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5631) Spc7 PF08317.11 PIK47839.1 - 0.7 8.7 31.0 0.2 10.5 23.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein ERM PF00769.19 PIK47839.1 - 0.93 9.3 32.3 2.4 7.9 32.3 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family LRRFIP PF09738.9 PIK47839.1 - 0.99 8.8 24.5 2.1 7.7 24.5 1.8 1 1 0 1 1 1 0 LRRFIP family Lebercilin PF15619.6 PIK47839.1 - 1 9.0 32.7 5.2 6.7 20.4 2.9 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease UPF0242 PF06785.11 PIK47839.1 - 1.1 9.3 30.1 0.53 10.4 17.0 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 PIK47839.1 - 1.2 9.7 27.2 2.5 8.6 8.7 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 ADIP PF11559.8 PIK47839.1 - 1.2 9.3 26.7 2.2 8.3 13.0 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.10 PIK47839.1 - 1.2 9.3 23.6 0.37 11.0 10.6 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family HemX PF04375.14 PIK47839.1 - 1.2 8.3 16.7 0.11 11.8 5.7 2.3 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase HrpB7 PF09486.10 PIK47839.1 - 1.6 9.1 17.7 6.5 7.1 6.2 2.9 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) COG5 PF10392.9 PIK47839.1 - 2.7 8.2 14.7 1.9 8.7 0.6 3.1 1 1 2 3 3 3 0 Golgi transport complex subunit 5 DUF724 PF05266.14 PIK47839.1 - 2.9 7.7 26.8 2.1 8.1 10.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF745 PF05335.13 PIK47839.1 - 3.8 7.2 20.3 1.1 8.9 10.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) HIP1_clath_bdg PF16515.5 PIK47839.1 - 4.4 8.0 30.2 1.9 9.1 8.2 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Lectin_N PF03954.14 PIK47839.1 - 4.5 7.0 12.0 14 5.4 4.4 2.9 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Fzo_mitofusin PF04799.13 PIK47839.1 - 4.8 6.7 15.7 5.5 6.5 0.3 2.9 2 1 1 3 3 3 0 fzo-like conserved region CEP63 PF17045.5 PIK47839.1 - 5.4 6.8 30.2 5.6 6.8 17.0 2.5 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa HU-CCDC81_bac_2 PF18175.1 PIK47839.1 - 7.5 6.5 8.2 2.8 7.9 0.4 3.4 3 1 1 4 4 3 0 CCDC81-like prokaryotic HU domain 2 Csm1_N PF18504.1 PIK47839.1 - 8.8 6.7 24.6 2.8 8.4 3.0 4.3 2 2 1 3 3 3 0 Csm1 N-terminal domain Sec2p PF06428.11 PIK47839.1 - 10 6.2 27.4 0.18 11.8 13.4 3.2 1 1 3 4 4 4 0 GDP/GTP exchange factor Sec2p MATH PF00917.26 PIK47840.1 - 0.0098 16.0 0.8 0.92 9.7 0.1 2.9 1 1 1 2 2 2 1 MATH domain DUF4200 PF13863.6 PIK47840.1 - 0.028 14.8 1.6 0.053 13.9 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) FUSC PF04632.12 PIK47840.1 - 0.085 11.4 0.0 0.11 11.0 0.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-C3HC4_2 PF13923.6 PIK47841.1 - 1.6e-10 40.6 7.7 1.6e-10 40.6 7.7 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 PIK47841.1 - 1.5e-09 38.4 14.9 4.8e-08 33.6 4.9 3.0 3 0 0 3 3 3 2 TRAF-type zinc finger zf-C3HC4_4 PF15227.6 PIK47841.1 - 2.7e-07 30.6 6.9 2.7e-07 30.6 6.9 2.4 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK47841.1 - 3.3e-07 30.1 6.2 3.3e-07 30.1 6.2 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK47841.1 - 1.2e-06 28.4 9.9 1.2e-06 28.4 9.9 2.1 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK47841.1 - 1.3e-06 28.7 7.5 1.3e-06 28.7 7.5 2.9 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK47841.1 - 3.4e-06 26.9 5.6 3.4e-06 26.9 5.6 2.9 2 1 0 2 2 2 1 zinc-RING finger domain Sina PF03145.16 PIK47841.1 - 7.1e-06 26.1 1.2 1.2e-05 25.3 1.2 1.4 1 0 0 1 1 1 1 Seven in absentia protein family zf-C3HC4_3 PF13920.6 PIK47841.1 - 7.5e-06 25.7 5.7 7.5e-06 25.7 5.7 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 PIK47841.1 - 1.6e-05 25.0 0.0 3.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 PIK47841.1 - 0.00088 19.0 3.1 0.00088 19.0 3.1 2.6 1 1 1 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 PIK47841.1 - 0.0095 15.8 2.5 0.019 14.9 2.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 PIK47841.1 - 0.013 15.3 0.7 0.013 15.3 0.7 2.6 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK47841.1 - 0.12 12.7 12.5 0.065 13.5 6.5 3.1 2 1 1 3 3 3 0 RING-H2 zinc finger domain DUF1272 PF06906.11 PIK47841.1 - 4.2 7.5 14.1 3.7 7.7 0.7 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1272) OMPdecase PF00215.24 PIK47842.1 - 8.2e-74 248.0 0.6 1.1e-73 247.5 0.6 1.2 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 PIK47842.1 - 2.5e-10 40.1 0.0 5.2e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TTL PF03133.15 PIK47843.1 - 1.2e-109 366.0 0.3 1.6e-109 365.6 0.3 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK47843.1 - 4.2e-07 29.5 0.0 0.00015 21.1 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK47843.1 - 3.6e-05 23.2 0.0 0.00055 19.3 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RVT_1 PF00078.27 PIK47844.1 - 2e-24 86.3 0.0 3.5e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ApoLp-III PF07464.11 PIK47844.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Methyltransf_23 PF13489.6 PIK47845.1 - 2.1e-05 24.4 0.0 3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK47845.1 - 0.02 15.6 0.0 0.039 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK47845.1 - 0.067 13.9 0.0 0.12 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 PIK47845.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Ets PF00178.22 PIK47846.1 - 2.9e-30 104.6 4.4 6.7e-30 103.4 4.4 1.7 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 PIK47846.1 - 1.6e-20 72.8 0.1 3.4e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain ATF7IP_BD PF16788.5 PIK47846.1 - 1.1 9.4 5.7 0.44 10.6 0.9 2.3 2 0 0 2 2 2 0 ATF-interacting protein binding domain Mob1_phocein PF03637.17 PIK47847.1 - 6.6e-56 189.0 3.3 8.2e-56 188.6 3.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family 7tm_1 PF00001.21 PIK47848.1 - 1.8e-07 30.8 8.8 2.8e-07 30.1 8.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TadE PF07811.12 PIK47848.1 - 0.21 11.9 1.1 0.59 10.5 1.1 1.8 1 0 0 1 1 1 0 TadE-like protein DIRP PF06584.13 PIK47849.1 - 5.4e-38 129.4 0.4 1.5e-37 128.0 0.4 1.8 1 0 0 1 1 1 1 DIRP Thioredoxin PF00085.20 PIK47850.1 - 2.4e-08 33.9 0.1 4.4e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 PIK47850.1 - 3.3e-05 23.0 0.4 3.4e-05 22.9 0.4 1.0 1 0 0 1 1 1 1 Phosducin Astro_capsid_p PF12226.8 PIK47852.1 - 0.25 10.5 8.6 0.42 9.7 8.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Importin_rep_4 PF18808.1 PIK47852.1 - 0.25 11.7 14.5 0.42 10.9 3.5 3.4 2 1 1 3 3 3 0 Importin repeat BUD22 PF09073.10 PIK47852.1 - 0.92 8.8 12.2 1.1 8.5 12.2 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 PIK47852.1 - 1.2 8.5 12.4 1.5 8.2 12.4 1.1 1 0 0 1 1 1 0 SDA1 Drc1-Sld2 PF11719.8 PIK47852.1 - 5.8 6.4 7.1 6.5 6.2 7.1 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Exo_endo_phos PF03372.23 PIK47853.1 - 5.4e-11 42.4 0.1 1.1e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Reeler PF02014.16 PIK47853.1 - 6.7e-11 43.1 0.1 1.5e-10 41.9 0.1 1.6 1 0 0 1 1 1 1 Reeler domain Exo_endo_phos_2 PF14529.6 PIK47853.1 - 8.1e-08 32.1 0.3 2.7e-06 27.2 0.2 2.9 2 1 1 3 3 3 1 Endonuclease-reverse transcriptase DUF4773 PF15998.5 PIK47853.1 - 0.077 13.5 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4773) HYR PF02494.16 PIK47854.1 - 1e-12 48.2 14.0 0.0018 18.5 0.4 4.4 4 0 0 4 4 4 4 HYR domain Big_7 PF17957.1 PIK47854.1 - 0.014 16.2 4.9 22 5.9 0.1 4.1 4 0 0 4 4 4 0 Bacterial Ig domain OrfB_Zn_ribbon PF07282.11 PIK47854.1 - 0.019 14.9 9.6 27 4.8 0.1 4.4 4 0 0 4 4 4 0 Putative transposase DNA-binding domain FDF PF09532.10 PIK47854.1 - 0.02 15.8 0.0 71 4.4 0.0 3.7 4 0 0 4 4 4 0 FDF domain Sipho_Gp37 PF14594.6 PIK47854.1 - 0.099 11.6 0.0 13 4.7 0.0 3.4 4 0 0 4 4 4 0 Siphovirus ReqiPepy6 Gp37-like protein DUF1331 PF07048.11 PIK47854.1 - 4.6 7.0 12.6 64 3.3 0.2 5.7 7 0 0 7 7 7 0 Protein of unknown function (DUF1331) Fmp27_WPPW PF10359.9 PIK47856.1 - 0.0077 15.1 0.2 0.01 14.7 0.2 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Transcrip_act PF04949.13 PIK47856.1 - 0.0085 16.0 1.3 0.42 10.5 0.2 2.3 2 0 0 2 2 2 1 Transcriptional activator StbA PF06406.11 PIK47856.1 - 0.025 13.9 0.1 0.047 12.9 0.0 1.5 1 1 0 1 1 1 0 StbA protein Laminin_I PF06008.14 PIK47856.1 - 0.05 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Laminin Domain I Laminin_II PF06009.12 PIK47856.1 - 0.085 12.9 0.2 0.21 11.6 0.2 1.8 1 1 0 1 1 1 0 Laminin Domain II Tropomyosin_1 PF12718.7 PIK47856.1 - 0.1 12.8 1.9 0.26 11.4 0.7 2.0 2 0 0 2 2 2 0 Tropomyosin like Snapin_Pallidin PF14712.6 PIK47856.1 - 0.1 13.0 0.1 1.2 9.6 0.1 2.3 2 0 0 2 2 2 0 Snapin/Pallidin VWD PF00094.25 PIK47857.1 - 5.9e-10 39.6 0.1 9.8e-10 38.9 0.1 1.3 1 1 0 1 1 1 1 von Willebrand factor type D domain Trehalase_Ca-bi PF07492.11 PIK47857.1 - 0.13 12.0 0.5 0.24 11.1 0.5 1.3 1 0 0 1 1 1 0 Neutral trehalase Ca2+ binding domain DUF1380 PF07128.12 PIK47858.1 - 0.13 12.5 0.1 13 5.9 0.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1380) Sugar_tr PF00083.24 PIK47859.1 - 2.2e-106 356.5 17.1 2.7e-106 356.2 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK47859.1 - 2.1e-25 89.4 21.2 1.6e-13 50.4 8.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.18 PIK47859.1 - 0.00062 18.6 0.8 0.0038 16.0 0.0 2.0 2 0 0 2 2 2 1 Reduced folate carrier MFS_1_like PF12832.7 PIK47859.1 - 0.00083 18.3 14.3 0.16 10.8 3.6 3.0 2 1 1 3 3 3 2 MFS_1 like family SNARE PF05739.19 PIK47859.1 - 0.07 13.1 0.3 0.19 11.7 0.3 1.8 1 0 0 1 1 1 0 SNARE domain Phage_holin_3_2 PF04550.12 PIK47859.1 - 4.4 7.9 6.3 1.7 9.3 2.3 2.3 2 0 0 2 2 2 0 Phage holin family 2 TssO PF17561.2 PIK47859.1 - 8.3 6.5 6.6 3.8 7.6 1.8 2.7 3 0 0 3 3 3 0 Type VI secretion system, TssO rve PF00665.26 PIK47860.1 - 8.2e-22 77.6 0.0 1.5e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK47860.1 - 4.6e-18 65.6 0.0 7.4e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_3 PF13358.6 PIK47860.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.6 PIK47860.1 - 0.00013 21.7 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 PIK47860.1 - 0.0017 18.3 15.6 0.015 15.3 3.6 2.4 2 0 0 2 2 2 2 Zinc knuckle DDE_Tnp_IS240 PF13610.6 PIK47860.1 - 0.035 14.3 0.0 0.59 10.4 0.0 2.5 2 0 0 2 2 2 0 DDE domain DUF2202 PF09968.9 PIK47860.1 - 0.22 11.3 0.0 1.7 8.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) Glypican PF01153.19 PIK47861.1 - 4e-102 342.9 0.1 5.9e-102 342.3 0.1 1.3 1 1 0 1 1 1 1 Glypican RecR PF02132.15 PIK47861.1 - 0.12 12.0 0.8 0.35 10.5 0.8 1.8 1 0 0 1 1 1 0 RecR protein Snapin_Pallidin PF14712.6 PIK47862.1 - 0.0098 16.3 0.3 0.034 14.6 0.3 1.9 1 0 0 1 1 1 1 Snapin/Pallidin AIP3 PF03915.13 PIK47862.1 - 0.025 13.7 0.1 0.047 12.8 0.1 1.4 1 0 0 1 1 1 0 Actin interacting protein 3 Death PF00531.22 PIK47862.1 - 0.065 13.4 0.0 0.44 10.8 0.0 2.4 2 0 0 2 2 2 0 Death domain DUF5588 PF17826.1 PIK47862.1 - 0.07 12.0 0.1 0.1 11.5 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) FmiP_Thoc5 PF09766.9 PIK47862.1 - 0.083 12.2 0.5 0.14 11.5 0.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 NPV_P10 PF05531.12 PIK47862.1 - 0.22 12.0 1.5 0.38 11.2 0.4 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein VID27 PF08553.10 PIK47863.1 - 0.029 13.4 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain DUF2207 PF09972.9 PIK47865.1 - 0.077 11.8 2.4 0.11 11.2 2.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Med4 PF10018.9 PIK47866.1 - 0.0026 17.5 2.4 0.0026 17.5 2.4 2.0 1 1 1 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 MCC-bdg_PDZ PF10506.9 PIK47866.1 - 0.0026 17.8 2.9 0.0041 17.1 2.0 1.7 1 1 1 2 2 2 1 PDZ domain of MCC-2 bdg protein for Usher syndrome UPF0242 PF06785.11 PIK47866.1 - 0.0031 17.7 12.7 0.0034 17.5 12.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 PIK47866.1 - 0.0054 16.7 2.9 0.0054 16.7 2.9 2.1 1 1 1 2 2 2 2 TATA element modulatory factor 1 DNA binding COG2 PF06148.11 PIK47866.1 - 0.0076 16.3 4.8 0.0097 16.0 4.8 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Med21 PF11221.8 PIK47866.1 - 0.018 15.3 7.8 0.024 14.9 7.8 1.2 1 0 0 1 1 1 0 Subunit 21 of Mediator complex DUF3552 PF12072.8 PIK47866.1 - 0.019 14.4 14.2 0.024 14.0 14.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF2730 PF10805.8 PIK47866.1 - 0.019 15.0 7.4 0.62 10.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) OmpH PF03938.14 PIK47866.1 - 0.025 14.9 14.0 0.033 14.5 14.0 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 PIK47866.1 - 0.028 14.8 18.9 0.12 12.8 18.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Myb_DNA-bind_6 PF13921.6 PIK47866.1 - 0.029 14.6 0.6 0.047 14.0 0.6 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain Ead_Ea22 PF13935.6 PIK47866.1 - 0.029 15.0 4.5 0.038 14.7 4.5 1.2 1 0 0 1 1 1 0 Ead/Ea22-like protein ATG16 PF08614.11 PIK47866.1 - 0.03 14.6 14.7 0.084 13.1 14.5 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spectrin PF00435.21 PIK47866.1 - 0.03 14.8 10.2 0.033 14.7 10.2 1.1 1 0 0 1 1 1 0 Spectrin repeat DUF812 PF05667.11 PIK47866.1 - 0.04 12.8 13.2 0.044 12.7 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) RuvB_N PF05496.12 PIK47866.1 - 0.08 12.7 0.5 0.097 12.4 0.5 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain BRE1 PF08647.11 PIK47866.1 - 0.099 12.7 15.1 0.1 12.7 13.9 1.7 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase KxDL PF10241.9 PIK47866.1 - 0.099 12.9 9.1 0.85 9.9 3.9 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein T3SSipB PF16535.5 PIK47866.1 - 0.11 13.0 6.0 0.12 12.8 6.0 1.0 1 0 0 1 1 1 0 Type III cell invasion protein SipB Laminin_II PF06009.12 PIK47866.1 - 0.11 12.5 7.0 0.13 12.3 7.0 1.1 1 0 0 1 1 1 0 Laminin Domain II Csm1_N PF18504.1 PIK47866.1 - 0.12 12.8 13.3 0.63 10.4 6.0 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain CEP63 PF17045.5 PIK47866.1 - 0.13 12.2 15.6 1.2 9.0 15.2 1.9 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa DUF641 PF04859.12 PIK47866.1 - 0.13 12.6 12.5 0.24 11.7 2.4 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc7 PF08317.11 PIK47866.1 - 0.16 10.8 15.2 0.54 9.1 15.2 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein zf-C4H2 PF10146.9 PIK47866.1 - 0.17 12.2 12.2 0.17 12.2 12.2 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein GAS PF13851.6 PIK47866.1 - 0.19 11.0 17.0 3.9 6.8 17.0 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF724 PF05266.14 PIK47866.1 - 0.21 11.4 15.0 0.29 11.0 15.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Tup_N PF08581.10 PIK47866.1 - 0.22 11.8 13.1 0.28 11.5 8.3 2.2 1 1 1 2 2 2 0 Tup N-terminal AAA_13 PF13166.6 PIK47866.1 - 0.25 10.0 9.4 0.25 10.0 9.4 1.0 1 0 0 1 1 1 0 AAA domain TMPIT PF07851.13 PIK47866.1 - 0.29 10.4 8.6 0.32 10.2 8.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein Nnf1 PF03980.14 PIK47866.1 - 0.3 11.5 12.5 0.22 11.9 2.6 2.8 1 1 2 3 3 3 0 Nnf1 SlyX PF04102.12 PIK47866.1 - 0.32 11.6 10.5 4.3 8.0 1.8 2.1 1 1 1 2 2 2 0 SlyX DUF948 PF06103.11 PIK47866.1 - 0.32 11.3 2.1 0.53 10.6 2.1 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 PIK47866.1 - 0.39 11.1 11.9 5.3 7.5 0.4 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) MMPL PF03176.15 PIK47866.1 - 0.4 9.5 1.7 0.47 9.3 1.7 1.1 1 0 0 1 1 1 0 MMPL family APG6_N PF17675.1 PIK47866.1 - 0.42 11.1 16.6 0.7 10.4 16.6 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 PIK47866.1 - 0.49 11.3 13.2 0.62 11.0 13.2 1.1 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF327 PF03885.13 PIK47866.1 - 0.64 10.0 11.4 0.29 11.1 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF327) CRA PF06589.11 PIK47866.1 - 0.9 9.7 9.6 0.42 10.7 6.9 1.7 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) Phage_GPO PF05929.11 PIK47866.1 - 0.94 9.0 7.9 0.97 9.0 7.9 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DivIC PF04977.15 PIK47866.1 - 1.1 9.1 12.3 0.29 10.9 3.9 2.2 1 1 0 2 2 2 0 Septum formation initiator BBS2_C PF14782.6 PIK47866.1 - 1.2 7.8 10.4 1.4 7.6 10.4 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal CREPT PF16566.5 PIK47866.1 - 1.4 9.1 10.1 1.8 8.8 10.1 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour KIAA1430 PF13879.6 PIK47866.1 - 1.5 9.6 13.0 0.077 13.8 5.8 2.0 1 1 0 2 2 2 0 KIAA1430 homologue GIT_CC PF16559.5 PIK47866.1 - 1.5 8.7 10.4 0.93 9.4 3.6 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FAM76 PF16046.5 PIK47866.1 - 1.5 8.1 12.5 1.7 8.0 12.5 1.1 1 0 0 1 1 1 0 FAM76 protein Fib_alpha PF08702.10 PIK47866.1 - 2.1 8.5 9.8 4.3 7.5 3.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TolA_bind_tri PF16331.5 PIK47866.1 - 2.4 8.3 11.2 0.48 10.5 3.1 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF1664 PF07889.12 PIK47866.1 - 2.5 8.2 8.1 11 6.0 8.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) EMP24_GP25L PF01105.24 PIK47866.1 - 2.5 8.0 10.5 7.5 6.4 10.4 1.7 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Atg14 PF10186.9 PIK47866.1 - 2.7 7.0 8.4 3.2 6.8 8.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 PIK47866.1 - 3 8.3 10.6 3.4 8.1 10.6 1.1 1 0 0 1 1 1 0 AAA domain YabA PF06156.13 PIK47866.1 - 3.1 8.5 12.9 0.39 11.4 5.1 2.0 1 1 0 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 PIK47866.1 - 3.5 6.9 7.5 6.1 6.1 7.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Rnk_N PF14760.6 PIK47866.1 - 4.1 8.0 9.1 3.1 8.4 4.9 2.6 2 1 0 2 2 2 0 Rnk N-terminus MRPL52 PF18699.1 PIK47866.1 - 4.6 7.5 12.6 1 9.6 7.0 2.1 1 1 1 2 2 2 0 Mitoribosomal protein mL52 V_ATPase_I PF01496.19 PIK47866.1 - 5 4.9 9.8 5.2 4.9 9.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fungal_TACC PF12709.7 PIK47866.1 - 5 7.6 14.1 3.3 8.2 5.7 2.2 1 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins GrpE PF01025.19 PIK47866.1 - 5.2 6.7 15.2 0.83 9.3 7.5 2.0 1 1 1 2 2 2 0 GrpE XhlA PF10779.9 PIK47866.1 - 6.9 7.0 10.1 3.2 8.0 7.0 1.9 1 1 1 2 2 2 0 Haemolysin XhlA Tropomyosin_1 PF12718.7 PIK47867.1 - 0.019 15.1 8.9 0.019 15.1 8.9 3.2 3 1 0 3 3 3 0 Tropomyosin like Fzo_mitofusin PF04799.13 PIK47867.1 - 0.019 14.5 9.5 0.019 14.5 9.5 2.8 2 1 1 3 3 3 0 fzo-like conserved region Atypical_Card PF18461.1 PIK47867.1 - 0.43 10.8 0.0 0.43 10.8 0.0 3.5 3 1 0 3 3 3 0 Atypical caspase recruitment domain Filament PF00038.21 PIK47869.1 - 0.046 13.3 32.8 0.35 10.4 15.3 3.6 1 1 2 3 3 3 0 Intermediate filament protein NYD-SP28 PF14772.6 PIK47869.1 - 0.089 12.9 28.5 0.083 12.9 10.5 3.4 1 1 2 3 3 3 0 Sperm tail CALCOCO1 PF07888.11 PIK47869.1 - 0.1 11.5 28.7 0.15 10.9 25.1 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like SlyX PF04102.12 PIK47869.1 - 0.72 10.5 14.2 3.5 8.3 1.0 4.0 2 1 2 4 4 4 0 SlyX DUF4407 PF14362.6 PIK47869.1 - 1 8.7 11.3 1 8.7 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 PIK47869.1 - 1.3 7.8 27.2 0.37 9.6 14.8 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF5339 PF17274.2 PIK47869.1 - 2.7 8.9 9.6 0.076 13.9 1.9 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5339) MnmE_helical PF12631.7 PIK47869.1 - 6.6 6.8 15.9 0.74 9.9 6.7 2.2 1 1 1 2 2 2 0 MnmE helical domain Lectin_N PF03954.14 PIK47869.1 - 7.6 6.3 15.8 1.3 8.8 3.7 3.5 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF4797 PF16051.5 PIK47870.1 - 0.11 12.5 0.4 0.25 11.3 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4797) Glyco_transf_7C PF02709.14 PIK47871.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Glycos_transf_2 PF00535.26 PIK47872.1 - 8.4e-24 84.3 0.0 1.9e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK47872.1 - 5.7e-06 26.6 1.6 1.1e-05 25.7 1.6 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 PIK47872.1 - 1.1e-05 24.9 0.0 3.1e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 PIK47872.1 - 0.00071 19.5 0.0 0.002 18.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 PIK47872.1 - 0.015 16.0 0.3 2.2 9.1 0.0 2.6 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Granulin PF00396.18 PIK47873.1 - 0 1363.2 994.0 8.5e-17 61.2 21.5 44.0 53 3 3 56 56 56 31 Granulin HCV_NS5a PF01506.19 PIK47873.1 - 0.082 12.8 0.1 1.8e+02 2.2 0.0 4.5 3 0 0 3 3 3 0 Hepatitis C virus non-structural 5a protein membrane anchor Granulin PF00396.18 PIK47874.1 - 1e-19 70.6 48.2 7.1e-11 42.3 10.3 3.0 2 1 1 3 3 3 3 Granulin Mcl1_mid PF12341.8 PIK47875.1 - 2.1e-91 306.4 0.0 1e-90 304.1 0.0 2.0 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 PIK47875.1 - 7.2e-12 45.6 11.4 0.00089 20.0 0.0 6.4 6 2 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK47875.1 - 6.9e-09 35.9 2.0 3.7e-05 23.9 0.1 5.1 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BIR PF00653.21 PIK47875.1 - 0.027 15.1 0.1 2.3 8.9 0.0 2.7 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain eIF2A PF08662.11 PIK47875.1 - 0.089 12.7 0.1 0.78 9.6 0.0 2.5 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 PIK47875.1 - 0.18 11.5 1.3 3.9 7.1 0.1 3.0 3 0 0 3 3 3 0 TUP1-like enhancer of split FYVE PF01363.21 PIK47876.1 - 3.5e-09 36.6 10.5 3.5e-09 36.6 10.5 2.5 2 0 0 2 2 2 1 FYVE zinc finger zf-B_box PF00643.24 PIK47876.1 - 0.49 10.6 28.0 0.081 13.1 10.8 3.5 3 0 0 3 3 3 0 B-box zinc finger Carbpep_Y_N PF05388.11 PIK47877.1 - 0.097 13.2 0.1 1.9 9.1 0.0 2.0 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide HEAT PF02985.22 PIK47878.1 - 2.9e-13 48.8 10.8 0.0074 16.5 0.5 7.0 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 PIK47878.1 - 1e-07 32.2 0.0 0.006 16.9 0.0 4.5 4 2 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 PIK47878.1 - 1.3e-05 25.6 5.3 6.6e-05 23.3 0.1 4.2 4 1 1 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 PIK47878.1 - 0.00062 19.9 0.0 1.1 9.3 0.0 4.0 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 PIK47878.1 - 0.0012 17.3 0.0 1.5 7.0 0.0 3.4 4 0 0 4 4 4 2 Down-regulated in metastasis Vac14_Fab1_bd PF12755.7 PIK47878.1 - 0.0018 18.8 0.0 1.9 9.2 0.0 3.3 3 1 0 3 3 3 2 Vacuolar 14 Fab1-binding region DUF1778 PF08681.11 PIK47880.1 - 0.053 13.5 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) Laminin_II PF06009.12 PIK47881.1 - 0.0082 16.2 4.1 0.0082 16.2 4.1 3.8 2 1 2 4 4 4 1 Laminin Domain II CALCOCO1 PF07888.11 PIK47881.1 - 4.8 5.9 51.9 0.014 14.3 16.1 2.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like FlaC_arch PF05377.11 PIK47881.1 - 7.2 7.1 16.0 5.2 7.5 2.1 5.1 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) E1-E2_ATPase PF00122.20 PIK47882.1 - 0.18 11.3 0.9 3 7.3 0.1 2.7 2 0 0 2 2 2 0 E1-E2 ATPase GST_N_4 PF17172.4 PIK47882.1 - 8.5 7.2 10.3 2.5 8.9 0.8 4.1 3 2 0 3 3 3 0 Glutathione S-transferase N-terminal domain DUF3914 PF13053.6 PIK47883.1 - 0.017 15.4 0.6 0.043 14.2 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3914) CRT10 PF08728.10 PIK47883.1 - 0.33 9.1 9.8 0.38 8.9 9.8 1.2 1 0 0 1 1 1 0 CRT10 DUF2207 PF09972.9 PIK47883.1 - 3.4 6.3 8.8 0.97 8.1 5.2 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) MCC-bdg_PDZ PF10506.9 PIK47884.1 - 0.044 13.8 0.8 0.044 13.8 0.8 4.7 5 2 2 7 7 7 0 PDZ domain of MCC-2 bdg protein for Usher syndrome GAS PF13851.6 PIK47884.1 - 0.63 9.4 73.7 0.032 13.6 12.1 5.1 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding HALZ PF02183.18 PIK47885.1 - 0.45 10.8 7.6 2.4 8.4 0.2 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper YflT PF11181.8 PIK47885.1 - 9.5 6.8 8.4 26 5.4 0.7 3.3 2 1 1 3 3 3 0 Heat induced stress protein YflT DNA_pol_B_palm PF14792.6 PIK47886.1 - 0.42 10.8 3.7 0.67 10.2 0.3 2.8 1 1 2 3 3 3 0 DNA polymerase beta palm DUF2207 PF09972.9 PIK47887.1 - 0.03 13.1 0.7 0.042 12.6 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4797 PF16051.5 PIK47887.1 - 0.15 12.0 0.2 0.38 10.7 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4797) HALZ PF02183.18 PIK47888.1 - 0.29 11.4 8.1 2.3 8.5 0.2 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper Fez1 PF06818.15 PIK47889.1 - 8.7 6.7 51.7 1.6 9.1 15.0 3.0 1 1 2 3 3 3 0 Fez1 Filament PF00038.21 PIK47890.1 - 0.0023 17.6 26.5 0.011 15.3 7.5 2.0 1 1 1 2 2 2 2 Intermediate filament protein Lectin_N PF03954.14 PIK47890.1 - 0.016 14.9 1.2 0.016 14.9 1.2 3.1 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Prominin PF05478.11 PIK47890.1 - 0.024 12.6 19.7 0.076 11.0 3.3 2.0 1 1 1 2 2 2 0 Prominin DUF1664 PF07889.12 PIK47890.1 - 0.032 14.3 2.1 0.032 14.3 2.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 PIK47890.1 - 0.062 13.0 16.3 0.099 12.3 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) TACC_C PF05010.14 PIK47890.1 - 0.16 11.7 28.5 0.034 13.9 7.3 2.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal WEMBL PF05701.11 PIK47890.1 - 0.28 9.8 22.8 0.6 8.7 22.7 1.5 1 1 0 1 1 1 0 Weak chloroplast movement under blue light SlyX PF04102.12 PIK47890.1 - 0.33 11.6 10.6 2.8 8.6 0.4 3.6 2 2 1 3 3 3 0 SlyX DivIC PF04977.15 PIK47890.1 - 0.36 10.6 12.6 0.12 12.1 0.9 3.5 2 2 0 3 3 3 0 Septum formation initiator GIT_CC PF16559.5 PIK47890.1 - 0.37 10.7 16.5 0.84 9.5 3.4 3.6 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 PIK47890.1 - 0.58 10.6 22.3 0.57 10.6 5.9 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.12 PIK47890.1 - 0.65 10.1 28.3 0.17 12.0 8.1 3.2 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2625 PF10946.8 PIK47890.1 - 0.7 8.9 4.3 0.34 9.9 0.9 2.0 2 1 0 2 2 2 0 Protein of unknown function DUF2625 CALCOCO1 PF07888.11 PIK47890.1 - 0.7 8.7 25.9 0.098 11.5 8.6 2.7 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like YabA PF06156.13 PIK47890.1 - 0.76 10.5 22.4 3.4 8.4 8.9 2.8 1 1 0 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 PIK47890.1 - 1.2 9.4 17.8 0.99 9.7 0.2 4.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper TolA_bind_tri PF16331.5 PIK47890.1 - 1.2 9.2 12.8 8.7 6.5 2.5 3.5 3 1 0 3 3 3 0 TolA binding protein trimerisation DUF5339 PF17274.2 PIK47890.1 - 1.8 9.5 9.8 0.15 12.9 0.8 3.2 2 2 0 3 3 2 0 Family of unknown function (DUF5339) DHR10 PF18595.1 PIK47890.1 - 1.9 8.6 28.6 0.066 13.3 6.7 2.5 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Synaptonemal_3 PF15191.6 PIK47890.1 - 3.9 7.3 13.2 1.8 8.4 4.0 2.6 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 DUF3450 PF11932.8 PIK47890.1 - 4.1 6.6 17.9 0.22 10.8 4.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4472 PF14739.6 PIK47890.1 - 4.2 8.1 22.4 0.83 10.4 7.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) GAS PF13851.6 PIK47890.1 - 4.3 6.6 31.5 0.13 11.6 9.3 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding YflT PF11181.8 PIK47890.1 - 4.7 7.8 10.9 17 6.0 1.1 3.1 2 1 1 3 3 3 0 Heat induced stress protein YflT ADIP PF11559.8 PIK47890.1 - 5.5 7.1 32.0 3.9 7.5 10.5 3.0 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF5320 PF17253.2 PIK47890.1 - 6.6 7.9 10.2 3.5 8.8 0.7 3.1 1 1 1 3 3 2 0 Family of unknown function (DUF5320) Laminin_II PF06009.12 PIK47890.1 - 8.2 6.4 17.6 0.29 11.1 5.2 2.4 2 1 0 2 2 2 0 Laminin Domain II BRE1 PF08647.11 PIK47890.1 - 9 6.4 29.6 0.072 13.2 9.5 2.8 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Tho1_MOS11_C PF18592.1 PIK47891.1 - 1.3 8.9 10.1 7.1 6.5 1.1 3.8 3 0 0 3 3 3 0 Tho1/MOS11 C-terminal domain DUF2207 PF09972.9 PIK47892.1 - 0.012 14.4 0.6 0.017 13.9 0.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4797 PF16051.5 PIK47892.1 - 0.2 11.6 0.4 0.43 10.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4797) DUF4201 PF13870.6 PIK47893.1 - 0.0084 15.9 7.5 0.01 15.6 7.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) YabA PF06156.13 PIK47893.1 - 0.04 14.6 3.4 0.072 13.7 3.4 1.4 1 0 0 1 1 1 0 Initiation control protein YabA DUF2625 PF10946.8 PIK47893.1 - 0.16 11.0 1.0 0.31 10.1 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2625 2OG-FeII_Oxy_2 PF13532.6 PIK47895.1 - 1.8e-20 74.0 0.1 5.6e-20 72.4 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 PIK47895.1 - 1.7e-12 47.8 0.1 3.7e-12 46.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK47895.1 - 1.5e-11 44.9 0.2 4.2e-11 43.4 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK47895.1 - 5.9e-07 29.4 0.1 1e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK47895.1 - 1.9e-05 25.3 0.0 4.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK47895.1 - 0.00041 20.2 0.0 0.00086 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 PIK47895.1 - 0.00049 19.8 0.1 0.00083 19.0 0.1 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 PIK47895.1 - 0.0015 17.9 0.1 0.004 16.5 0.1 1.7 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 PIK47895.1 - 0.0071 15.3 0.1 0.018 14.0 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 PIK47895.1 - 0.0095 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family 2OG-FeII_Oxy PF03171.20 PIK47895.1 - 0.021 15.3 0.0 0.05 14.1 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily eRF1_1 PF03463.15 PIK47895.1 - 0.049 13.6 1.7 0.066 13.2 0.9 1.6 1 1 0 1 1 1 0 eRF1 domain 1 PCMT PF01135.19 PIK47895.1 - 0.11 12.2 0.0 0.79 9.4 0.0 2.2 3 0 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) COesterase PF00135.28 PIK47896.1 - 3e-114 382.7 0.0 3.6e-114 382.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK47896.1 - 5e-08 33.1 0.5 4.8e-07 29.9 0.4 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Ribos_L4_asso_C PF14374.6 PIK47897.1 - 1.9e-22 79.1 5.7 1.9e-22 79.1 5.7 2.4 3 0 0 3 3 3 1 60S ribosomal protein L4 C-terminal domain Ribosomal_L4 PF00573.22 PIK47897.1 - 2.9e-09 36.9 0.4 6.7e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family REPA_OB_2 PF16900.5 PIK47898.1 - 3.3e-05 23.7 0.4 5.6e-05 23.0 0.4 1.4 1 0 0 1 1 1 1 Replication protein A OB domain DUF3127 PF11325.8 PIK47898.1 - 0.0017 18.6 0.1 0.0038 17.4 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3127) SMODS PF18144.1 PIK47899.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain UPF0242 PF06785.11 PIK47901.1 - 0.00016 21.9 13.3 0.00043 20.4 13.3 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 PIK47901.1 - 0.0025 18.1 16.6 0.0037 17.5 16.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK47901.1 - 0.0076 16.7 14.1 0.013 16.0 14.1 1.2 1 0 0 1 1 1 1 Fez1 Orthoreo_P10 PF07204.11 PIK47901.1 - 0.029 14.3 0.1 0.054 13.5 0.1 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Ig_3 PF13927.6 PIK47901.1 - 0.04 14.5 0.2 0.28 11.8 0.2 2.5 1 0 0 1 1 1 0 Immunoglobulin domain Hydrophobin_2 PF06766.11 PIK47901.1 - 0.084 12.8 7.0 13 5.9 0.2 3.8 3 0 0 3 3 3 0 Fungal hydrophobin ig PF00047.25 PIK47901.1 - 0.11 12.7 0.2 0.39 10.9 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain RSN1_TM PF13967.6 PIK47901.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport APG6_N PF17675.1 PIK47901.1 - 0.11 13.0 19.6 0.18 12.3 19.6 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region HMMR_N PF15905.5 PIK47901.1 - 0.15 11.5 19.4 0.22 11.0 19.4 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.9 PIK47901.1 - 0.33 10.4 14.1 0.47 9.9 14.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.11 PIK47901.1 - 0.63 8.9 17.0 0.9 8.4 17.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Nucleoside_tran PF01733.18 PIK47901.1 - 0.65 9.3 3.4 2.1 7.7 3.4 1.8 1 1 0 1 1 1 0 Nucleoside transporter BST2 PF16716.5 PIK47901.1 - 0.67 10.6 16.3 3.9 8.1 14.2 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 FAM76 PF16046.5 PIK47901.1 - 0.73 9.1 11.5 1.2 8.5 11.5 1.3 1 0 0 1 1 1 0 FAM76 protein FlaC_arch PF05377.11 PIK47901.1 - 1.6 9.2 12.5 1.6 9.1 1.3 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 PIK47901.1 - 1.9 9.2 12.2 0.87 10.2 2.8 2.3 1 1 1 2 2 2 0 SlyX Atg14 PF10186.9 PIK47901.1 - 2.3 7.2 12.3 3.7 6.5 12.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YlqD PF11068.8 PIK47901.1 - 2.3 8.6 15.1 1.1 9.7 12.1 1.8 2 0 0 2 2 2 0 YlqD protein Exonuc_VII_L PF02601.15 PIK47901.1 - 3.2 7.2 8.1 4.9 6.6 8.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3552 PF12072.8 PIK47901.1 - 5.7 6.3 20.6 12 5.2 20.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) DUF641 PF04859.12 PIK47901.1 - 6.1 7.2 15.5 1.1 9.6 5.2 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 PIK47901.1 - 6.8 5.9 10.8 12 5.1 10.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 PIK47901.1 - 9.9 6.8 18.0 38 5.0 17.3 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 V-set PF07686.17 PIK47902.1 - 0.00011 22.3 0.1 0.00018 21.7 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain HYR PF02494.16 PIK47902.1 - 0.00013 22.3 2.7 0.016 15.5 0.5 2.3 2 0 0 2 2 2 2 HYR domain TRAP-delta PF05404.12 PIK47902.1 - 0.05 13.1 0.0 0.95 9.0 0.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) Stevor PF17410.2 PIK47902.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Ig_3 PF13927.6 PIK47902.1 - 0.31 11.7 0.1 0.31 11.7 0.1 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Hydrophobin_2 PF06766.11 PIK47902.1 - 3.9 7.5 6.5 8.8 6.4 0.7 2.9 2 2 0 2 2 2 0 Fungal hydrophobin Tme5_EGF_like PF09064.10 PIK47902.1 - 9.5 6.2 14.0 5 7.1 3.2 2.8 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like GIY-YIG PF01541.24 PIK47905.1 - 3.5e-05 24.0 0.2 8.4e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 GIY-YIG catalytic domain DUF2922 PF11148.8 PIK47905.1 - 0.11 12.3 0.1 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Ig_3 PF13927.6 PIK47907.1 - 0.00092 19.8 0.1 0.0027 18.3 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK47907.1 - 0.0015 18.7 0.1 0.0025 18.0 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK47907.1 - 0.078 13.2 0.1 0.16 12.2 0.1 1.5 1 1 0 1 1 1 0 Immunoglobulin domain Integrase_H2C2 PF17921.1 PIK47908.1 - 5.6e-16 58.4 0.6 9.2e-16 57.7 0.6 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK47908.1 - 6.8e-15 55.3 0.1 1.3e-13 51.2 0.0 2.3 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK47908.1 - 7.4e-05 22.5 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK47909.1 - 1.9e-25 88.8 0.0 3.2e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK47909.1 - 1.8e-13 50.7 0.0 3.5e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK47909.1 - 6.5e-13 48.7 0.2 1.5e-12 47.5 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 PIK47909.1 - 0.018 14.5 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain DUF2362 PF10154.9 PIK47909.1 - 0.038 12.9 0.0 0.046 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) DUF5498 PF17602.2 PIK47909.1 - 0.19 12.2 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5498) zf-CCHC PF00098.23 PIK47910.1 - 0.00021 21.2 4.1 0.00021 21.2 4.1 1.9 2 0 0 2 2 2 1 Zinc knuckle TniQ PF06527.11 PIK47910.1 - 0.014 16.1 0.9 0.057 14.1 1.0 2.1 1 1 0 1 1 1 0 TniQ Allexi_40kDa PF05549.11 PIK47910.1 - 0.057 12.9 0.1 0.08 12.4 0.1 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DMAP1 PF05499.12 PIK47910.1 - 0.084 12.8 2.7 0.14 12.0 2.7 1.4 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) TackOD1 PF18551.1 PIK47910.1 - 0.23 11.1 8.8 0.4 10.3 7.4 1.9 2 1 1 3 3 3 0 Thaumarchaeal output domain 1 zf-CCHC_4 PF14392.6 PIK47910.1 - 8.3 6.2 6.8 11 5.9 5.8 1.7 2 0 0 2 2 2 0 Zinc knuckle BTB PF00651.31 PIK47911.1 - 9.8e-23 80.5 0.0 1.4e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 PIK47912.1 - 9.9e-50 165.9 2.4 7.4e-10 38.3 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK47912.1 - 2.6e-38 129.0 2.6 1.4e-08 34.7 0.1 6.9 5 2 2 7 7 7 6 Kelch motif BACK PF07707.15 PIK47912.1 - 7.2e-28 96.7 0.8 1.1e-27 96.1 0.8 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 PIK47912.1 - 3.6e-25 86.9 2.9 2.4e-06 27.3 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 PIK47912.1 - 3.8e-25 87.6 0.9 7.8e-06 25.8 0.1 5.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK47912.1 - 1.8e-24 85.4 0.2 5.5e-06 26.5 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK47912.1 - 4.3e-13 48.9 4.8 7.9e-05 22.5 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Ran_BP1 PF00638.18 PIK47913.1 - 5.1e-11 42.9 0.1 1.5e-10 41.4 0.1 1.8 1 0 0 1 1 1 1 RanBP1 domain TPR_19 PF14559.6 PIK47914.1 - 1.8e-08 34.8 6.1 0.025 15.1 0.2 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK47914.1 - 3.2e-05 24.4 3.0 0.6 11.1 0.0 6.1 6 1 1 8 8 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK47914.1 - 3.2e-05 23.5 1.0 0.34 10.6 0.0 5.4 6 0 0 6 6 6 1 TPR repeat YL1 PF05764.13 PIK47914.1 - 0.00012 22.3 11.3 0.00023 21.4 11.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 PIK47914.1 - 0.00052 18.5 8.6 0.00092 17.6 8.6 1.3 1 0 0 1 1 1 1 CDC45-like protein TPR_8 PF13181.6 PIK47914.1 - 0.0079 16.3 12.0 8.9 6.8 0.0 6.6 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK47914.1 - 0.0095 16.3 1.9 0.93 10.0 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK47914.1 - 0.016 15.3 11.5 2.2 8.6 0.2 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK47914.1 - 0.018 15.7 0.0 11 6.8 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2659 PF10858.8 PIK47914.1 - 0.021 14.5 0.2 0.049 13.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) TPR_15 PF13429.6 PIK47914.1 - 0.038 13.2 2.4 0.58 9.3 0.2 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK47914.1 - 0.1 12.5 1.2 3.1 7.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Nop14 PF04147.12 PIK47914.1 - 0.26 9.5 16.7 0.48 8.6 16.7 1.3 1 0 0 1 1 1 0 Nop14-like family Clathrin PF00637.20 PIK47914.1 - 0.31 10.9 5.7 0.2 11.5 0.4 3.1 2 1 0 3 3 3 0 Region in Clathrin and VPS TFIIF_alpha PF05793.12 PIK47914.1 - 0.5 8.9 16.7 1 7.9 16.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TPR_1 PF00515.28 PIK47914.1 - 0.89 9.5 12.2 0.31 10.9 0.7 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Vfa1 PF08432.10 PIK47914.1 - 6 7.2 10.3 26 5.1 10.3 2.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Myc_N PF01056.18 PIK47914.1 - 7.3 6.4 11.8 15 5.3 11.8 1.5 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.13 PIK47914.1 - 7.4 4.5 23.7 18 3.2 23.7 1.6 1 0 0 1 1 1 0 DNA polymerase phi ORC_WH_C PF18137.1 PIK47914.1 - 8.2 6.5 8.3 25 4.9 8.3 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Merozoite_SPAM PF07133.11 PIK47914.1 - 8.2 6.4 30.4 29 4.6 30.4 1.9 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CCDC24 PF15669.5 PIK47915.1 - 2.7e-55 187.4 6.2 5.5e-55 186.4 6.2 1.5 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family DUF2294 PF10057.9 PIK47915.1 - 0.17 12.0 1.7 0.22 11.7 0.4 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2294) betaPIX_CC PF16523.5 PIK47915.1 - 3.7 7.4 8.7 0.49 10.3 0.3 3.0 3 2 0 3 3 3 0 betaPIX coiled coil NAD_binding_6 PF08030.12 PIK47916.1 - 6.8e-29 101.0 2.0 8.7e-29 100.7 0.0 2.2 3 0 0 3 3 3 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 PIK47916.1 - 6.4e-20 71.3 0.0 1.3e-16 60.6 0.0 2.5 2 0 0 2 2 2 2 FAD-binding domain Ferric_reduct PF01794.19 PIK47916.1 - 1.3e-05 25.3 1.7 2.6e-05 24.3 1.7 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 PIK47916.1 - 0.0082 16.8 0.0 0.044 14.4 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 PIK47916.1 - 0.047 14.1 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain TM2 PF05154.16 PIK47917.1 - 3.6e-16 59.2 5.1 5.4e-16 58.7 5.1 1.2 1 0 0 1 1 1 1 TM2 domain Ribosomal_L7Ae PF01248.26 PIK47918.1 - 3.6e-08 33.0 0.0 6.4e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HopJ PF08888.11 PIK47918.1 - 0.069 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 HopJ type III effector protein NHL PF01436.21 PIK47919.1 - 0.0012 18.8 0.1 5.5 7.2 0.0 4.5 5 0 0 5 5 5 3 NHL repeat NACHT PF05729.12 PIK47921.1 - 1.1e-10 41.7 0.0 3.3e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK47921.1 - 0.00012 21.7 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF3368 PF11848.8 PIK47921.1 - 0.02 14.6 0.6 0.1 12.4 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) AAA_22 PF13401.6 PIK47921.1 - 0.024 14.9 0.0 0.079 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain GPI2 PF06432.11 PIK47921.1 - 0.049 13.1 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase DAP3 PF10236.9 PIK47921.1 - 0.067 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 PIK47921.1 - 0.13 12.7 0.1 3 8.3 0.0 2.8 3 0 0 3 3 3 0 RNA helicase LAMTOR PF15454.6 PIK47922.1 - 0.035 14.7 1.0 0.07 13.8 1.0 1.5 1 0 0 1 1 1 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator VapB_antitoxin PF09957.9 PIK47924.1 - 0.057 13.3 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB Pkinase PF00069.25 PIK47925.1 - 7.4e-43 146.8 0.1 1.3e-42 146.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47925.1 - 1e-16 61.0 1.1 1.2e-12 47.7 0.9 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 PIK47925.1 - 0.0004 20.4 0.0 0.0011 18.9 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK47925.1 - 0.0041 16.5 0.1 0.0093 15.3 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK47925.1 - 0.009 15.6 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 PIK47925.1 - 0.015 14.9 0.2 0.049 13.2 0.0 1.9 1 1 1 2 2 2 0 RIO1 family ABC1 PF03109.16 PIK47925.1 - 0.047 13.9 0.0 0.087 13.0 0.0 1.4 1 0 0 1 1 1 0 ABC1 family PCRF PF03462.18 PIK47926.1 - 0.094 12.6 7.8 0.022 14.7 3.5 2.1 2 1 1 3 3 3 0 PCRF domain Mst1_SARAH PF11629.8 PIK47926.1 - 1.1 9.4 3.6 0.77 9.9 0.9 2.2 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 CENP-H PF05837.12 PIK47926.1 - 1.8 9.0 13.6 11 6.4 7.6 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Nore1-SARAH PF16517.5 PIK47926.1 - 3.5 7.6 6.5 16 5.5 1.9 2.6 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Uso1_p115_C PF04871.13 PIK47926.1 - 8.5 6.8 13.3 3.1 8.2 9.8 1.8 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region zf-RING_UBOX PF13445.6 PIK47927.1 - 4.6e-10 39.4 2.9 4.6e-10 39.4 2.9 3.2 3 1 1 4 4 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK47927.1 - 4.2e-09 36.1 7.1 4.2e-09 36.1 7.1 3.3 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK47927.1 - 3.2e-07 30.1 6.1 3.2e-07 30.1 6.1 3.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK47927.1 - 5.7e-07 29.8 6.5 5.7e-07 29.8 6.5 3.7 3 1 1 4 4 3 1 Ring finger domain zf-B_box PF00643.24 PIK47927.1 - 6.6e-07 29.4 27.5 0.00011 22.2 7.9 4.2 5 0 0 5 5 4 2 B-box zinc finger zf-C3HC4_4 PF15227.6 PIK47927.1 - 1.3e-06 28.5 7.6 1.3e-06 28.5 7.6 3.6 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK47927.1 - 2.9e-06 27.0 7.9 2.9e-06 27.0 7.9 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK47927.1 - 0.00022 21.1 7.4 0.00022 21.1 7.4 3.7 3 0 0 3 3 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK47927.1 - 0.0017 18.2 6.1 0.0017 18.2 6.1 3.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 DUF5530 PF17670.1 PIK47927.1 - 0.019 14.7 0.6 0.57 10.0 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5530) DUF4295 PF14128.6 PIK47927.1 - 0.03 14.1 0.1 0.076 12.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) zf-RING_11 PF17123.5 PIK47927.1 - 0.22 11.3 5.6 0.49 10.2 2.7 2.9 2 0 0 2 2 2 0 RING-like zinc finger Spc7 PF08317.11 PIK47927.1 - 0.25 10.2 27.3 0.99 8.2 12.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein PIN_2 PF10130.9 PIK47927.1 - 0.26 11.5 3.4 0.28 11.4 0.8 2.4 2 0 0 2 2 2 0 PIN domain DUF3450 PF11932.8 PIK47927.1 - 0.41 9.9 10.3 1.4 8.2 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4085 PF13315.6 PIK47927.1 - 0.86 9.2 11.5 0.33 10.5 0.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF4085) DUF3584 PF12128.8 PIK47927.1 - 0.96 6.9 21.9 1.4 6.3 21.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spectrin PF00435.21 PIK47927.1 - 1.4 9.5 14.2 0.33 11.5 1.0 2.7 2 0 0 2 2 2 0 Spectrin repeat Apolipoprotein PF01442.18 PIK47927.1 - 3.8 7.4 13.3 7.5 6.4 13.3 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 PIK47927.1 - 4.6 7.3 11.7 1.1 9.4 3.4 2.8 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF1351 PF07083.11 PIK47927.1 - 5.1 6.8 25.2 2 8.1 7.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1351) DivIVA PF05103.13 PIK47927.1 - 9 6.4 17.5 2.4 8.2 9.6 3.0 1 1 0 3 3 3 0 DivIVA protein DUF1043 PF06295.12 PIK47927.1 - 9.2 6.3 13.7 1.2 9.1 8.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1043) SOBP PF15279.6 PIK47928.1 - 0.14 12.8 9.5 0.17 12.5 9.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Vir_act_alpha_C PF10400.9 PIK47928.1 - 3.6 8.3 6.1 18 6.1 4.3 2.7 1 1 1 2 2 2 0 Virulence activator alpha C-term FMO-like PF00743.19 PIK47929.1 - 1.1e-118 397.0 0.0 1.4e-118 396.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK47929.1 - 1.2e-12 47.7 0.3 1.5e-10 40.8 0.4 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK47929.1 - 1.1e-09 37.9 0.0 9.7e-07 28.2 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 PIK47929.1 - 1.4e-09 37.6 0.0 3e-09 36.5 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK47929.1 - 3.2e-05 24.1 0.4 0.00036 20.7 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 PIK47929.1 - 0.0049 17.4 0.2 2.8 8.6 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK47929.1 - 0.0071 15.6 0.6 0.37 10.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 PIK47929.1 - 0.025 14.6 0.2 0.32 11.0 0.0 2.9 3 2 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 PIK47929.1 - 0.054 12.6 0.1 5.3 6.0 0.1 2.8 2 1 1 3 3 3 0 FAD binding domain HI0933_like PF03486.14 PIK47929.1 - 0.17 10.6 0.2 0.49 9.0 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 PIK47929.1 - 0.2 11.2 0.0 16 5.0 0.0 3.1 4 0 0 4 4 4 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 PIK47929.1 - 0.26 10.6 0.2 1 8.7 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Neurexophilin PF06312.12 PIK47932.1 - 6.5e-08 32.3 0.0 1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin HMG_box_2 PF09011.10 PIK47936.1 - 9.2e-05 23.0 0.1 0.00028 21.4 0.1 1.9 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 PIK47936.1 - 0.0025 18.2 0.1 0.009 16.4 0.1 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box AnfO_nitrog PF09582.10 PIK47936.1 - 0.094 12.0 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) V-set PF07686.17 PIK47939.1 - 2.4e-05 24.5 0.4 0.29 11.3 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK47939.1 - 5e-05 23.3 0.5 0.029 14.4 0.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ubiq_cyt_C_chap PF03981.12 PIK47939.1 - 0.0049 17.0 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DUF2207 PF09972.9 PIK47939.1 - 0.046 12.5 0.9 0.086 11.6 0.9 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Imm25 PF15564.6 PIK47939.1 - 0.086 12.8 0.8 0.37 10.7 0.3 2.2 2 0 0 2 2 2 0 Immunity protein 25 Ig_3 PF13927.6 PIK47939.1 - 0.12 13.0 2.9 49 4.6 0.0 4.9 4 1 0 4 4 4 0 Immunoglobulin domain Actin PF00022.19 PIK47940.1 - 4.2e-147 490.0 0.0 1.5e-146 488.2 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 PIK47940.1 - 0.031 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain RRM_1 PF00076.22 PIK47941.1 - 9.3e-30 102.3 0.0 9.7e-14 50.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 PIK47941.1 - 0.1 12.8 0.0 0.87 9.9 0.0 2.1 2 0 0 2 2 2 0 BRCA1-associated protein 2 CXCXC PF03128.14 PIK47941.1 - 2.2 8.9 4.7 0.4 11.2 0.6 1.9 2 0 0 2 2 2 0 CXCXC repeat 7tm_1 PF00001.21 PIK47942.1 - 6.7e-31 107.6 12.6 9.7e-31 107.0 12.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK47942.1 - 6.9e-08 32.4 15.5 6.9e-08 32.4 15.5 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK47942.1 - 1.5e-05 24.5 12.5 0.00041 19.8 12.5 2.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK47942.1 - 2.2e-05 24.0 2.2 2.2e-05 24.0 2.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv CLP1_P PF16575.5 PIK47943.1 - 1.5e-72 243.3 0.0 2.1e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 PIK47943.1 - 1.1e-31 108.9 0.1 2.5e-31 107.8 0.0 1.7 2 0 0 2 2 2 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 PIK47943.1 - 1.8e-29 102.5 0.1 3.1e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CbiA PF01656.23 PIK47943.1 - 0.00018 21.5 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 PIK47943.1 - 0.002 18.2 0.0 0.0056 16.8 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 PIK47943.1 - 0.0044 16.8 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 PIK47943.1 - 0.0046 16.8 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 PIK47943.1 - 0.045 14.1 0.0 0.082 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain EAF PF09816.9 PIK47944.1 - 1.8e-21 76.4 0.0 1.8e-21 76.4 0.0 2.5 2 1 0 2 2 2 1 RNA polymerase II transcription elongation factor Cwf_Cwc_15 PF04889.12 PIK47944.1 - 0.0045 16.8 35.1 0.0045 16.8 35.1 1.8 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein GREB1 PF15782.5 PIK47944.1 - 0.18 8.9 26.9 0.21 8.7 26.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4407 PF14362.6 PIK47944.1 - 0.49 9.7 15.2 0.64 9.3 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.9 PIK47944.1 - 0.69 8.4 30.1 1.1 7.8 30.1 1.3 1 0 0 1 1 1 0 Macoilin family eIF-3_zeta PF05091.12 PIK47944.1 - 2.6 6.9 26.1 4.2 6.2 26.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ion_trans PF00520.31 PIK47946.1 - 3.4e-25 88.7 4.7 5.2e-25 88.1 4.5 1.3 1 1 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK47946.1 - 1.1e-10 41.4 0.0 2.8e-10 40.1 0.0 1.6 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain DUF2613 PF11021.8 PIK47947.1 - 0.0014 18.7 0.1 0.0029 17.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2613) LapA_dom PF06305.11 PIK47947.1 - 0.022 14.6 0.8 0.037 13.9 0.8 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SCF PF02404.15 PIK47947.1 - 0.024 14.0 0.0 0.028 13.8 0.0 1.0 1 0 0 1 1 1 0 Stem cell factor DUF4690 PF15756.5 PIK47947.1 - 0.025 15.1 0.0 0.038 14.6 0.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage TMEM119 PF15724.5 PIK47947.1 - 0.13 12.3 0.4 0.2 11.7 0.0 1.4 2 0 0 2 2 2 0 TMEM119 family Sigma_reg_N PF13800.6 PIK47947.1 - 0.15 12.3 0.4 1.9 8.8 0.5 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Syndecan PF01034.20 PIK47947.1 - 0.17 11.8 1.9 0.28 11.1 1.9 1.3 1 0 0 1 1 1 0 Syndecan domain Spore_YpjB PF09577.10 PIK47947.1 - 0.3 10.8 0.1 0.39 10.5 0.1 1.2 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) TNFR_16_TM PF18422.1 PIK47947.1 - 2.1 8.4 4.5 4.9 7.2 4.5 1.6 1 1 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain CbtB PF09489.10 PIK47947.1 - 8.4 6.6 8.3 2.5 8.3 4.1 1.9 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) Adeno_E3_CR2 PF02439.15 PIK47947.1 - 8.4 6.2 8.6 0.2 11.4 1.8 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 F5_F8_type_C PF00754.25 PIK47948.1 - 1.7e-12 47.6 0.0 2e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain Pkinase PF00069.25 PIK47949.1 - 3.9e-25 88.7 0.0 8.6e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47949.1 - 3.1e-22 79.1 0.0 5.2e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Occludin_ELL PF07303.13 PIK47949.1 - 0.028 15.1 1.9 10 6.9 0.6 2.9 1 1 1 2 2 2 0 Occludin homology domain Baculo_PEP_C PF04513.12 PIK47949.1 - 0.038 14.0 0.0 0.17 11.9 0.0 2.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pkinase_Tyr PF07714.17 PIK47950.1 - 0.0065 15.8 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase AbrB_C PF18277.1 PIK47950.1 - 0.0075 15.9 1.4 27 4.5 0.1 4.1 4 0 0 4 4 4 0 AbrB C-terminal domain DUF4482 PF14818.6 PIK47950.1 - 0.024 15.5 1.5 0.024 15.5 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) OmpH PF03938.14 PIK47950.1 - 0.024 15.0 0.6 0.024 15.0 0.6 3.0 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Vip3A_N PF12495.8 PIK47950.1 - 0.04 13.8 2.7 0.095 12.6 2.7 1.6 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal CLZ PF16526.5 PIK47950.1 - 0.22 11.9 10.0 2.2 8.7 0.1 3.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TetR_C_15 PF17918.1 PIK47950.1 - 0.36 11.6 2.2 7.1 7.4 0.1 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF1664 PF07889.12 PIK47950.1 - 0.37 10.8 6.8 2.8 8.0 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) RPEL PF02755.15 PIK47950.1 - 0.41 10.4 2.3 0.58 9.9 0.1 2.6 2 0 0 2 2 2 0 RPEL repeat ParB PF08775.10 PIK47950.1 - 0.82 10.2 8.6 10 6.6 2.3 2.7 3 0 0 3 3 3 0 ParB family Erp_C PF06780.11 PIK47950.1 - 1.6 8.7 6.5 21 5.1 0.2 3.3 2 1 1 3 3 3 0 Erp protein C-terminus KxDL PF10241.9 PIK47950.1 - 2.1 8.7 9.2 15 6.0 0.1 4.3 4 1 1 5 5 5 0 Uncharacterized conserved protein RasGEF PF00617.19 PIK47951.1 - 6.1e-57 192.7 0.6 6.1e-57 192.7 0.6 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 PIK47951.1 - 6e-15 55.4 3.2 9.7e-15 54.7 0.3 2.9 3 0 0 3 3 3 1 RasGEF N-terminal motif RA PF00788.23 PIK47951.1 - 6.7e-05 23.4 0.0 0.00034 21.2 0.0 2.2 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PI_PP_I PF18363.1 PIK47951.1 - 0.04 14.1 3.6 0.45 10.7 0.1 3.7 4 0 0 4 4 4 0 Phosphoinositide phosphatase insertion domain Choline_transpo PF04515.12 PIK47953.1 - 1.3e-98 330.2 38.7 1.3e-98 330.2 38.7 1.5 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF2244 PF10003.9 PIK47953.1 - 0.036 13.7 0.0 0.036 13.7 0.0 4.2 5 1 1 6 6 6 0 Integral membrane protein (DUF2244) Thyroglobulin_1 PF00086.18 PIK47954.1 - 1.2e-12 47.3 1.8 1.6e-12 46.9 0.2 1.9 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Triabin PF03973.13 PIK47954.1 - 1.4e-06 28.3 0.1 5.8e-06 26.2 0.1 1.9 1 1 0 1 1 1 1 Triabin Lipocalin_2 PF08212.12 PIK47954.1 - 0.0002 21.3 0.2 0.00064 19.7 0.2 1.7 1 1 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 PIK47954.1 - 0.0014 18.8 0.0 0.0045 17.2 0.0 1.9 2 0 0 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family BNR_2 PF13088.6 PIK47955.1 - 2.9e-25 89.1 0.0 3.7e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 PIK47955.1 - 1.8e-08 34.1 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK47955.1 - 2e-07 29.9 12.0 0.025 14.5 1.0 4.7 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_4 PF15892.5 PIK47955.1 - 0.0031 16.9 0.0 0.016 14.5 0.0 1.9 1 1 0 2 2 2 1 BNR repeat-containing family member CyRPA PF18638.1 PIK47955.1 - 0.026 13.7 0.9 2.4 7.2 0.0 2.9 2 1 1 3 3 3 0 Cysteine-Rich Protective Antigen 6 bladed domain Sortilin-Vps10 PF15902.5 PIK47955.1 - 0.075 11.8 0.0 0.26 10.0 0.0 1.7 1 1 1 2 2 2 0 Sortilin, neurotensin receptor 3, HEPN_AbiA_CTD PF18732.1 PIK47955.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 HEPN like, Abia C-terminal domain Rieske PF00355.26 PIK47956.1 - 3.8e-06 26.8 0.0 8.3e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2043 PF09740.9 PIK47956.1 - 0.8 10.4 3.5 3 8.6 0.4 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2043) Peptidase_M35 PF02102.15 PIK47957.1 - 0.019 13.8 1.3 0.029 13.3 1.3 1.2 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family DUF148 PF02520.17 PIK47957.1 - 0.39 10.9 4.8 0.77 9.9 2.1 2.7 2 1 1 3 3 3 0 Domain of unknown function DUF148 WW PF00397.26 PIK47958.1 - 6.1e-08 32.6 0.2 6.1e-08 32.6 0.2 1.9 2 0 0 2 2 2 1 WW domain Glyco_hyd_101C PF17451.2 PIK47958.1 - 0.074 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain PIN_4 PF13638.6 PIK47959.1 - 3.1e-27 95.4 0.0 9e-27 93.9 0.0 1.9 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 PIK47959.1 - 0.011 16.0 0.0 1.1 9.6 0.0 3.1 1 1 1 2 2 2 0 PIN like domain PIN_8 PF18476.1 PIK47959.1 - 0.033 14.1 2.4 0.11 12.4 0.0 3.0 3 1 0 3 3 3 0 PIN like domain Y2_Tnp PF04986.13 PIK47959.1 - 0.2 11.7 0.1 0.57 10.2 0.1 1.7 1 0 0 1 1 1 0 Putative transposase Galactosyl_T PF01762.21 PIK47960.1 - 1.8e-30 106.2 0.0 2.3e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Pkinase_Tyr PF07714.17 PIK47961.1 - 0.065 12.5 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase DTHCT PF08070.11 PIK47962.1 - 0.051 14.3 8.4 0.08 13.7 8.4 1.4 1 0 0 1 1 1 0 DTHCT (NUC029) region SOUL PF04832.12 PIK47963.1 - 2.1e-27 96.4 0.0 8.1e-27 94.4 0.0 1.8 2 0 0 2 2 2 1 SOUL heme-binding protein Arg_repressor PF01316.21 PIK47963.1 - 0.053 13.3 1.2 0.21 11.4 1.3 1.9 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain Ribosomal_L35Ae PF01247.18 PIK47963.1 - 0.075 13.2 0.0 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L35Ae SOUL PF04832.12 PIK47964.1 - 1.7e-18 67.4 0.0 2.6e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 SOUL heme-binding protein SOUL PF04832.12 PIK47965.1 - 2.3e-47 161.3 0.3 2.7e-47 161.1 0.3 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein TPR_14 PF13428.6 PIK47966.1 - 2.3e-20 71.5 8.5 0.062 14.2 0.0 11.7 10 3 2 12 12 11 3 Tetratricopeptide repeat Suf PF05843.14 PIK47966.1 - 8.2e-12 45.7 14.9 0.0036 17.3 0.0 6.1 4 3 2 6 6 6 3 Suppressor of forked protein (Suf) TPR_2 PF07719.17 PIK47966.1 - 3.2e-09 36.2 15.9 0.0026 17.7 0.0 7.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK47966.1 - 4.4e-09 36.7 4.0 3.4 8.2 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK47966.1 - 3.1e-08 33.2 11.3 0.0051 16.9 0.0 7.6 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK47966.1 - 3.1e-07 29.9 2.7 0.069 12.3 0.2 4.4 3 2 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK47966.1 - 3.9e-07 30.2 4.3 0.43 10.9 0.0 6.5 6 2 0 6 6 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 PIK47966.1 - 2e-06 27.2 11.8 0.042 13.0 0.3 6.7 3 2 0 3 3 3 2 NRDE-2, necessary for RNA interference Mad3_BUB1_I PF08311.12 PIK47966.1 - 3.3e-06 27.1 16.7 0.85 9.6 0.0 7.4 6 2 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_1 PF00515.28 PIK47966.1 - 6.1e-05 22.7 9.5 0.13 12.1 0.0 6.4 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK47966.1 - 0.00011 21.9 4.9 0.011 15.7 0.0 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat RPN7 PF10602.9 PIK47966.1 - 0.00038 20.2 1.5 1.5 8.5 0.0 3.4 3 0 0 3 3 3 2 26S proteasome subunit RPN7 TPR_6 PF13174.6 PIK47966.1 - 0.0009 19.7 3.4 31 5.5 0.0 6.3 5 1 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 PIK47966.1 - 0.0045 17.0 2.4 1.7 8.7 0.0 5.0 6 0 0 6 6 5 1 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 PIK47966.1 - 0.0058 16.5 5.5 0.82 9.6 0.0 5.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK47966.1 - 0.11 12.2 5.1 7.7 6.2 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 PIK47966.1 - 0.32 10.7 6.8 6.1 6.6 0.0 5.0 6 0 0 6 6 6 0 TPR repeat TPR_4 PF07721.14 PIK47966.1 - 0.4 11.5 2.3 27 5.8 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat PPR PF01535.20 PIK47966.1 - 0.46 10.8 5.0 1.2 9.6 0.0 4.3 5 0 0 5 5 2 0 PPR repeat TPR_17 PF13431.6 PIK47966.1 - 0.73 10.3 14.5 64 4.3 0.1 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat CHDCT2 PF08074.11 PIK47967.1 - 0.65 10.2 8.4 0.79 9.9 8.4 1.1 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain eIF3_subunit PF08597.10 PIK47967.1 - 2.3 8.1 8.1 2.7 7.8 8.1 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit GATA PF00320.27 PIK47968.1 - 0.014 15.0 0.2 0.036 13.7 0.2 1.7 1 0 0 1 1 1 0 GATA zinc finger DUF1324 PF07038.11 PIK47968.1 - 0.16 12.2 1.5 0.25 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) DENN PF02141.21 PIK47969.1 - 4.8e-19 69.0 0.2 9.3e-19 68.1 0.2 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 PIK47969.1 - 2.5e-08 33.8 3.7 5.2e-08 32.8 3.7 1.6 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 PIK47969.1 - 0.0039 17.9 0.1 0.01 16.6 0.1 1.7 1 0 0 1 1 1 1 uDENN domain Pyrophosphatase PF00719.19 PIK47969.1 - 0.15 11.9 0.4 1.2 8.9 0.1 2.1 2 0 0 2 2 2 0 Inorganic pyrophosphatase Amino_oxidase PF01593.24 PIK47970.1 - 3e-41 142.2 0.0 3.8e-41 141.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK47970.1 - 4.6e-08 33.2 0.0 9.8e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK47970.1 - 4.8e-08 32.5 0.1 7.7e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 PIK47970.1 - 6.9e-06 25.4 0.1 0.00095 18.3 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 PIK47970.1 - 1.1e-05 25.2 0.0 0.0015 18.2 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 PIK47970.1 - 1.3e-05 24.4 0.1 0.0057 15.8 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 PIK47970.1 - 0.00026 20.3 0.1 0.072 12.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK47970.1 - 0.0033 16.7 0.4 1.1 8.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK47970.1 - 0.034 14.1 0.2 4.7 7.2 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 PIK47970.1 - 0.075 12.2 0.0 0.64 9.1 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 PIK47970.1 - 0.081 12.2 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK47970.1 - 0.14 10.8 0.1 1.9 7.1 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 PIK47970.1 - 0.18 10.9 0.4 0.72 8.9 0.0 2.0 2 1 1 3 3 3 0 Glucose inhibited division protein A adh_short PF00106.25 PIK47971.1 - 1.3e-22 80.2 0.3 4.5e-22 78.5 0.4 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK47971.1 - 1e-14 54.7 0.0 2e-14 53.7 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 PIK47971.1 - 2.3e-07 30.5 0.0 3.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 PIK47971.1 - 2.4e-06 27.6 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 PIK47971.1 - 4.8e-05 22.9 0.2 0.00014 21.4 0.2 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Methyltransf_PK PF05891.12 PIK47973.1 - 2.6e-63 213.5 0.0 3.1e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 PIK47973.1 - 6.5e-06 25.6 0.0 9.3e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 PIK47973.1 - 9.8e-06 26.2 0.0 1.4e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK47973.1 - 3.5e-05 24.4 0.0 5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK47973.1 - 0.00025 21.7 0.0 0.00034 21.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK47973.1 - 0.015 15.1 0.0 0.053 13.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 PIK47973.1 - 0.067 12.2 0.0 0.084 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Spermine_synth PF01564.17 PIK47973.1 - 0.069 12.6 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain MTS PF05175.14 PIK47973.1 - 0.069 12.7 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain zf-H2C2_5 PF13909.6 PIK47975.1 - 2.4e-06 27.2 1.2 2.4e-06 27.2 1.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-Di19 PF05605.12 PIK47975.1 - 0.0011 19.2 1.1 0.0011 19.2 1.1 2.8 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 PIK47975.1 - 0.18 12.3 0.4 0.18 12.3 0.4 3.4 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK47976.1 - 3.2e-09 36.4 4.8 2.3e-06 27.2 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-Di19 PF05605.12 PIK47976.1 - 0.00069 19.9 0.9 0.0013 19.0 0.4 1.7 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 PIK47976.1 - 0.15 12.6 4.4 0.21 12.1 0.4 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type RVT_1 PF00078.27 PIK47977.1 - 0.00071 19.2 0.4 0.0048 16.4 0.4 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) C2-set_2 PF08205.12 PIK47978.1 - 0.0024 17.9 0.1 0.0038 17.3 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK47978.1 - 0.02 15.5 0.3 4.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain GPS PF01825.21 PIK47978.1 - 0.1 13.1 1.2 0.24 12.0 1.2 1.5 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif C2-set_2 PF08205.12 PIK47979.1 - 9.1e-06 25.7 0.2 0.057 13.5 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK47979.1 - 2e-05 24.8 0.8 0.19 12.1 0.0 4.2 3 1 1 4 4 4 1 Immunoglobulin domain Ig_3 PF13927.6 PIK47979.1 - 0.00016 22.2 3.9 0.43 11.2 0.0 4.4 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK47979.1 - 0.0086 16.1 0.0 2.5 8.2 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 PIK47979.1 - 0.014 15.6 0.1 0.097 12.8 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin V-set domain DUF1677 PF07911.13 PIK47979.1 - 0.14 12.6 0.1 0.89 10.0 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1677) ig PF00047.25 PIK47979.1 - 0.17 12.1 1.6 7.3 6.8 0.1 3.5 4 1 0 4 4 4 0 Immunoglobulin domain PQ-loop PF04193.14 PIK47980.1 - 8e-20 70.4 4.2 2e-19 69.1 4.2 1.6 1 0 0 1 1 1 1 PQ loop repeat Dynein_C PF18199.1 PIK47982.1 - 4e-30 105.1 0.0 1.3e-29 103.4 0.0 1.8 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 PIK47982.1 - 5.7e-22 78.3 0.0 1.2e-21 77.2 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK47982.1 - 3.2e-20 72.4 0.6 8.8e-20 71.0 0.1 2.1 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_9 PF12781.7 PIK47982.1 - 5.9e-17 61.5 7.8 2.3e-08 33.4 0.0 3.3 2 1 1 3 3 3 2 ATP-binding dynein motor region MT PF12777.7 PIK47982.1 - 8.5e-06 25.0 1.9 1.3e-05 24.4 0.3 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Kinesin PF00225.23 PIK47983.1 - 3.5e-24 85.3 1.1 3.8e-24 85.2 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK47984.1 - 8.3e-23 81.0 0.3 3.7e-18 65.9 0.0 2.6 1 1 1 2 2 2 2 Microtubule binding Kinesin PF00225.23 PIK47984.1 - 7.2e-17 61.3 0.2 9.7e-10 37.9 0.1 2.3 1 1 1 2 2 2 2 Kinesin motor domain Occludin_ELL PF07303.13 PIK47984.1 - 0.19 12.4 8.6 0.096 13.4 4.0 2.7 1 1 1 2 2 2 0 Occludin homology domain Cnn_1N PF07989.11 PIK47984.1 - 2.2 8.5 15.9 0.22 11.7 3.7 3.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 PIK47984.1 - 5 6.1 11.1 13 4.7 11.2 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DNA_pol_A PF00476.20 PIK47985.1 - 1.1e-102 343.9 0.0 3.2e-102 342.4 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase family A DNA_pol_P_Exo PF18049.1 PIK47985.1 - 0.017 14.5 0.0 0.039 13.4 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase nu pseudo-exo DUF4332 PF14229.6 PIK47986.1 - 0.015 15.5 0.1 0.055 13.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) DEAD PF00270.29 PIK47987.1 - 1.9e-06 27.8 0.0 3.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 PIK47987.1 - 0.014 14.4 0.0 0.041 12.9 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Pkinase_Tyr PF07714.17 PIK47988.1 - 4.3e-82 275.3 0.0 1.1e-58 198.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK47988.1 - 1.1e-33 116.7 0.0 7.3e-31 107.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK47989.1 - 1e-35 121.9 29.9 3.4e-09 36.9 0.1 9.2 8 1 0 8 8 8 7 Fibronectin type III domain Ldl_recept_b PF00058.17 PIK47989.1 - 0.00011 22.5 8.9 3.4 8.2 0.0 6.2 7 0 0 7 7 7 2 Low-density lipoprotein receptor repeat class B Interfer-bind PF09294.10 PIK47989.1 - 0.0066 16.8 0.0 0.44 10.9 0.0 3.6 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III SGL PF08450.12 PIK47989.1 - 0.011 15.4 3.2 0.054 13.1 0.0 3.4 4 1 0 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region Pur_ac_phosph_N PF16656.5 PIK47989.1 - 0.024 15.2 23.5 1.4 9.6 0.2 7.9 8 0 0 8 8 8 0 Purple acid Phosphatase, N-terminal domain Adeno_E3_CR2 PF02439.15 PIK47989.1 - 0.071 12.9 2.0 0.14 11.9 2.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 PIK47989.1 - 0.18 12.7 0.0 0.44 11.5 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 PIK47989.1 - 0.91 9.0 7.7 2.1 7.9 7.7 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sua5_yciO_yrdC PF01300.18 PIK47990.1 - 1.5e-37 128.8 0.0 2e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination Methyltransf_3 PF01596.17 PIK47990.1 - 0.081 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase SIKE PF05769.11 PIK47990.1 - 0.11 12.5 1.5 1.5 8.7 0.2 2.1 2 0 0 2 2 2 0 SIKE family Pkinase PF00069.25 PIK47991.1 - 4e-57 193.6 0.0 4.8e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK47991.1 - 2.2e-34 118.9 0.2 4.8e-34 117.8 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK47991.1 - 2.5e-08 34.2 0.2 1.7e-06 28.2 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK47991.1 - 1.5e-06 27.4 1.4 1e-05 24.7 0.3 1.9 1 1 1 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 PIK47991.1 - 1.6e-06 27.7 0.3 3.8e-06 26.4 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK47991.1 - 1.8e-05 24.2 0.0 3.6e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 PIK47991.1 - 4.8e-05 23.0 0.3 7.4e-05 22.4 0.3 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 PIK47991.1 - 0.0017 17.2 0.0 0.0025 16.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 PIK47991.1 - 0.0022 17.6 0.1 0.0037 16.9 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Death PF00531.22 PIK47993.1 - 9.2e-09 35.4 0.5 2.1e-08 34.2 0.5 1.6 1 0 0 1 1 1 1 Death domain IHABP4_N PF16174.5 PIK47993.1 - 0.00014 22.5 0.9 0.00014 22.5 0.9 1.6 2 0 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal DUF809 PF05663.11 PIK47993.1 - 7.9 6.6 7.2 16 5.6 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) NDUF_B4 PF07225.12 PIK47994.1 - 1.5e-11 44.2 0.0 1.9e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) DUF4403 PF14356.6 PIK47994.1 - 0.13 10.9 0.0 0.13 10.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) Mid2 PF04478.12 PIK47994.1 - 1.5 8.7 3.5 2 8.2 0.7 2.0 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor WD40 PF00400.32 PIK47995.1 - 1.8e-05 25.4 7.4 9.8e-05 23.1 0.0 4.7 6 0 0 6 6 6 1 WD domain, G-beta repeat Nup160 PF11715.8 PIK47995.1 - 0.011 14.4 0.2 0.028 13.1 0.1 1.8 2 0 0 2 2 2 0 Nucleoporin Nup120/160 eIF-1a PF01176.19 PIK47996.1 - 5e-11 42.2 0.0 8.2e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 zf-RING_2 PF13639.6 PIK47997.1 - 3.1e-06 27.4 11.4 3.1e-06 27.4 11.4 2.1 2 0 0 2 2 1 1 Ring finger domain zf-ANAPC11 PF12861.7 PIK47997.1 - 6.8e-05 22.8 3.9 0.00014 21.8 3.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 PIK47997.1 - 0.00012 22.2 7.8 0.00012 22.2 7.8 2.0 2 0 0 2 2 2 1 FANCL C-terminal domain zf-rbx1 PF12678.7 PIK47997.1 - 0.00099 19.3 9.7 0.0028 17.9 9.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK47997.1 - 0.042 13.7 12.6 0.13 12.2 12.6 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 PIK47997.1 - 0.16 12.1 10.7 0.34 11.1 10.7 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 PIK47997.1 - 0.18 12.1 11.0 0.42 11.0 11.0 1.7 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 PIK47997.1 - 0.18 11.9 5.6 0.56 10.3 5.6 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.6 PIK47997.1 - 0.24 11.3 11.0 0.75 9.7 11.0 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 PIK47997.1 - 1.6 8.4 12.4 0.34 10.6 8.3 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 PIK47997.1 - 1.8 8.5 9.3 4.6 7.2 9.3 1.8 1 0 0 1 1 1 0 PHD-finger Fez1 PF06818.15 PIK47998.1 - 0.0005 20.6 16.7 0.0005 20.6 16.7 3.7 2 1 1 3 3 3 1 Fez1 HAUS-augmin3 PF14932.6 PIK47998.1 - 0.0039 16.8 18.8 0.0039 16.8 18.8 3.4 2 2 1 3 3 3 1 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 PIK47998.1 - 0.041 12.8 65.3 0.29 10.0 23.3 4.2 2 1 2 4 4 4 0 Spc7 kinetochore protein HALZ PF02183.18 PIK47998.1 - 0.077 13.2 0.3 0.077 13.2 0.3 6.8 7 0 0 7 7 7 0 Homeobox associated leucine zipper KASH_CCD PF14662.6 PIK47998.1 - 0.15 11.9 0.1 0.15 11.9 0.1 4.9 4 1 0 4 4 4 0 Coiled-coil region of CCDC155 or KASH CheY-binding PF09078.11 PIK47998.1 - 0.42 10.8 0.0 0.42 10.8 0.0 4.5 3 2 2 5 5 5 0 CheY binding HMMR_N PF15905.5 PIK47998.1 - 0.43 10.0 72.7 0.058 12.9 26.1 3.8 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF1664 PF07889.12 PIK47998.1 - 4.1 7.5 43.3 0.16 12.0 0.3 5.9 5 2 2 7 7 7 0 Protein of unknown function (DUF1664) DUF2407_C PF13373.6 PIK47998.1 - 6.4 6.9 10.6 22 5.2 0.8 3.0 2 0 0 2 2 2 0 DUF2407 C-terminal domain DED PF01335.21 PIK48000.1 - 3.4e-05 24.0 0.0 9.8e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 Death effector domain DUF1664 PF07889.12 PIK48000.1 - 0.0052 16.8 2.1 0.045 13.8 0.8 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1664) DUF2400 PF09674.10 PIK48000.1 - 0.018 15.0 1.1 0.032 14.2 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) Vps51 PF08700.11 PIK48000.1 - 0.047 13.8 1.5 0.12 12.5 1.5 1.8 1 1 0 1 1 1 0 Vps51/Vps67 DUF896 PF05979.12 PIK48000.1 - 0.07 13.0 0.7 0.2 11.6 0.6 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF896) DUF2508 PF10704.9 PIK48000.1 - 0.13 12.5 2.2 0.37 11.0 1.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2508) NACHT PF05729.12 PIK48001.1 - 3e-14 53.3 0.0 6.7e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK48001.1 - 8.9e-11 41.9 0.5 0.00013 22.1 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK48001.1 - 2.6e-06 28.0 5.0 0.068 13.8 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK48001.1 - 0.00046 20.2 2.1 1 9.5 0.2 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK48001.1 - 0.0087 16.1 0.6 2.9 8.0 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain DUF4731 PF15875.5 PIK48001.1 - 0.08 13.1 0.2 0.26 11.5 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4731) TMEM52 PF14979.6 PIK48007.1 - 0.023 14.6 4.8 0.055 13.4 4.8 1.6 1 0 0 1 1 1 0 Transmembrane 52 Plant_NMP1 PF06694.11 PIK48008.1 - 3.9e-17 62.4 1.9 3.8e-11 42.7 0.2 2.3 2 1 0 2 2 2 2 Plant nuclear matrix protein 1 (NMP1) TACC_C PF05010.14 PIK48008.1 - 0.0029 17.4 0.9 1.1 9.0 0.2 2.3 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Fib_alpha PF08702.10 PIK48008.1 - 0.02 15.0 2.2 7.7 6.7 0.0 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family SesA PF17107.5 PIK48008.1 - 0.023 14.9 1.0 0.4 10.9 0.0 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases APC1_C PF18122.1 PIK48008.1 - 0.03 14.3 0.3 0.24 11.4 0.3 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain NleF_casp_inhib PF16809.5 PIK48008.1 - 0.045 13.7 0.8 0.092 12.7 0.4 1.7 2 0 0 2 2 2 0 NleF caspase inhibitor Occludin_ELL PF07303.13 PIK48008.1 - 0.055 14.2 0.8 8 7.3 0.0 2.6 2 0 0 2 2 2 0 Occludin homology domain DUF3150 PF11348.8 PIK48008.1 - 0.063 12.5 0.0 0.14 11.3 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3150) PLU-1 PF08429.11 PIK48008.1 - 0.069 12.3 2.2 0.54 9.4 1.8 2.0 1 1 1 2 2 2 0 PLU-1-like protein Sec34 PF04136.15 PIK48008.1 - 0.071 13.0 4.8 1.5 8.7 1.2 2.4 2 0 0 2 2 2 0 Sec34-like family Csm2_III-A PF03750.13 PIK48008.1 - 0.073 13.9 0.4 9.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Csm2 Type III-A DUF948 PF06103.11 PIK48008.1 - 0.093 13.0 1.2 9.2 6.6 0.0 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) LXG PF04740.12 PIK48008.1 - 0.1 12.3 3.9 0.4 10.4 0.5 2.8 2 2 0 2 2 2 0 LXG domain of WXG superfamily PDE4_UCR PF18100.1 PIK48008.1 - 0.1 13.3 0.7 0.55 10.9 0.1 2.3 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) DUF713 PF05218.14 PIK48008.1 - 0.16 11.7 2.0 0.55 9.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF713) APG17 PF04108.12 PIK48008.1 - 0.26 10.4 5.7 0.48 9.5 0.5 2.2 2 0 0 2 2 2 0 Autophagy protein Apg17 DUF3924 PF13062.6 PIK48008.1 - 1.2 9.1 3.9 0.35 10.9 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) ThiF PF00899.21 PIK48009.1 - 2.1e-64 217.2 0.0 6.6e-33 114.1 0.0 3.1 3 0 0 3 3 3 3 ThiF family UBA_e1_thiolCys PF10585.9 PIK48009.1 - 4.3e-37 128.4 6.1 2.1e-12 47.5 0.1 3.7 2 1 2 4 4 4 3 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 PIK48009.1 - 4.8e-35 120.2 0.4 1.3e-34 118.8 0.4 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 PIK48009.1 - 7.2e-22 77.4 0.1 2e-21 76.0 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_FCCH PF16190.5 PIK48009.1 - 1.6e-15 57.0 0.1 3.9e-15 55.8 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain ThiF PF00899.21 PIK48010.1 - 7.1e-13 48.5 0.7 2.3e-11 43.5 0.1 2.1 2 0 0 2 2 2 2 ThiF family Sec20 PF03908.13 PIK48011.1 - 0.5 10.3 4.8 1.2 9.1 4.8 1.6 1 0 0 1 1 1 0 Sec20 BNR PF02012.20 PIK48011.1 - 0.86 9.9 2.8 43 4.7 0.2 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat RT_RNaseH PF17917.1 PIK48013.1 - 3.6e-18 65.8 0.1 9.5e-18 64.4 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK48013.1 - 6.8e-09 35.7 0.1 3.7e-08 33.3 0.0 2.2 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48014.1 - 6.1e-18 65.2 0.0 9.8e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK48014.1 - 0.0036 17.3 4.8 0.0036 17.3 4.8 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK48014.1 - 0.033 13.9 4.4 0.08 12.7 4.4 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger PH PF00169.29 PIK48015.1 - 1.1e-36 125.5 0.1 2.1e-19 70.0 0.0 2.6 3 0 0 3 3 3 2 PH domain DEP PF00610.21 PIK48015.1 - 6.5e-10 38.9 0.0 1.6e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_11 PF15413.6 PIK48015.1 - 9.5e-10 38.8 8.4 0.00048 20.5 0.4 3.5 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 PIK48015.1 - 5.4e-08 33.2 2.7 0.0066 16.8 0.5 3.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 PIK48015.1 - 1.1e-06 28.8 0.6 0.065 13.5 0.0 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_16 PF17838.1 PIK48015.1 - 2.5e-05 24.1 0.3 0.28 11.0 0.0 3.2 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 PIK48015.1 - 2.7e-05 24.1 2.9 0.049 13.4 0.0 2.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_4 PF15404.6 PIK48015.1 - 0.0044 16.8 4.1 0.39 10.5 1.0 3.4 3 1 0 3 3 3 1 Pleckstrin homology domain PsbP PF01789.16 PIK48015.1 - 0.016 15.3 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 PsbP Slx4 PF09494.10 PIK48015.1 - 0.12 12.4 0.0 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 Slx4 endonuclease zf-MYND PF01753.18 PIK48016.1 - 1.8e-10 40.7 17.0 3.9e-10 39.7 17.0 1.6 1 0 0 1 1 1 1 MYND finger CDI PF02234.19 PIK48016.1 - 0.069 13.4 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor Bunya_nucleocap PF00952.17 PIK48016.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Bunyavirus nucleocapsid (N) protein zf-HIT PF04438.16 PIK48016.1 - 0.26 11.2 7.1 0.57 10.1 7.1 1.6 1 0 0 1 1 1 0 HIT zinc finger zf-tcix PF14952.6 PIK48016.1 - 0.52 10.0 6.2 1 9.0 6.2 1.5 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding zf-C6H2 PF15801.5 PIK48016.1 - 2.2 8.6 12.0 6 7.3 12.0 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DcpS PF05652.12 PIK48017.1 - 2.9e-20 73.0 0.0 4.7e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 PIK48017.1 - 0.00017 22.0 0.0 0.00042 20.8 0.0 1.7 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding SBF PF01758.16 PIK48018.1 - 4.2e-20 72.2 11.9 5.5e-20 71.9 11.9 1.2 1 0 0 1 1 1 1 Sodium Bile acid symporter family SBF_like PF13593.6 PIK48018.1 - 3.5e-07 29.8 7.2 5.1e-07 29.3 7.2 1.2 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) RVT_1 PF00078.27 PIK48019.1 - 2.4e-10 40.3 0.0 3.1e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TSC22 PF01166.18 PIK48020.1 - 0.0049 17.1 1.4 0.0049 17.1 1.4 7.6 7 2 1 9 9 9 2 TSC-22/dip/bun family CENP-F_leu_zip PF10473.9 PIK48020.1 - 0.47 10.5 106.9 0.67 10.0 24.3 5.9 1 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lebercilin PF15619.6 PIK48020.1 - 5.3 6.7 106.5 0.019 14.6 23.6 4.4 1 1 3 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease PRKG1_interact PF15898.5 PIK48021.1 - 0.0024 18.8 4.7 0.0024 18.8 4.7 3.1 1 1 2 3 3 3 1 cGMP-dependent protein kinase interacting domain SKA2 PF16740.5 PIK48021.1 - 0.015 15.1 16.8 0.031 14.1 8.5 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 TPR_MLP1_2 PF07926.12 PIK48021.1 - 0.026 14.6 21.2 0.32 11.1 14.9 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein HALZ PF02183.18 PIK48021.1 - 0.06 13.6 7.8 0.061 13.6 0.9 3.3 2 1 1 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 PIK48021.1 - 0.11 12.7 22.1 0.11 12.7 9.3 2.5 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 PIK48021.1 - 0.14 12.6 20.3 0.065 13.7 5.6 3.3 1 1 2 3 3 3 0 Cell division protein ZapB Plasmid_RAQPRD PF09686.10 PIK48021.1 - 0.23 11.7 4.6 0.27 11.4 0.9 2.7 2 1 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Spc7 PF08317.11 PIK48021.1 - 0.29 10.0 22.1 0.89 8.4 14.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Rootletin PF15035.6 PIK48021.1 - 0.34 10.9 21.8 0.73 9.8 12.8 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FUSC PF04632.12 PIK48021.1 - 0.36 9.3 5.4 0.42 9.1 5.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 PIK48021.1 - 0.55 10.9 20.1 1.7 9.3 1.3 2.5 1 1 2 3 3 3 0 Initiation control protein YabA ADIP PF11559.8 PIK48021.1 - 0.58 10.2 22.8 2 8.5 1.4 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding RasGAP_C PF03836.15 PIK48021.1 - 0.59 10.3 15.6 0.32 11.2 1.9 2.3 1 1 1 2 2 2 0 RasGAP C-terminus Fib_alpha PF08702.10 PIK48021.1 - 0.69 10.1 10.6 0.51 10.5 4.5 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 PIK48021.1 - 1.2 8.4 12.5 2.5 7.4 12.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 PIK48021.1 - 1.6 8.8 10.3 2.8 8.0 5.9 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 PIK48021.1 - 1.9 6.3 12.7 2.8 5.7 12.6 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1640 PF07798.11 PIK48021.1 - 2.3 8.3 22.0 0.37 10.8 11.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF724 PF05266.14 PIK48021.1 - 2.4 7.9 20.2 1 9.1 12.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF724) FliD_N PF02465.18 PIK48021.1 - 3.1 8.6 10.2 66 4.3 10.0 2.5 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Fez1 PF06818.15 PIK48021.1 - 3.2 8.2 21.8 27 5.2 21.8 2.0 1 1 0 1 1 1 0 Fez1 FapA PF03961.13 PIK48021.1 - 5.3 5.5 18.8 5.4 5.5 1.1 2.1 1 1 0 2 2 2 0 Flagellar Assembly Protein A XhlA PF10779.9 PIK48021.1 - 7.6 6.8 8.6 19 5.5 6.1 3.0 2 1 0 2 2 2 0 Haemolysin XhlA wnt PF00110.19 PIK48022.1 - 3.3e-37 128.7 0.4 4e-37 128.4 0.4 1.1 1 0 0 1 1 1 1 wnt family SipA_VBS PF17985.1 PIK48022.1 - 0.18 11.8 0.7 0.6 10.1 0.9 1.8 2 0 0 2 2 2 0 SipA vinculin binding site wnt PF00110.19 PIK48023.1 - 1.3e-37 130.0 21.9 1.5e-37 129.9 21.9 1.0 1 0 0 1 1 1 1 wnt family Atx10homo_assoc PF09759.9 PIK48024.1 - 9.4e-32 109.0 7.3 1.1e-30 105.5 1.3 2.8 2 1 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Laminin_B PF00052.18 PIK48024.1 - 0.023 14.6 0.1 1.6 8.6 0.0 2.6 2 0 0 2 2 2 0 Laminin B (Domain IV) RIH_assoc PF08454.11 PIK48024.1 - 0.29 11.0 7.5 0.069 13.0 0.7 3.0 3 1 0 3 3 3 0 RyR and IP3R Homology associated SPA PF08616.10 PIK48025.1 - 2.3e-16 59.7 0.0 4.6e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 PIK48025.1 - 3e-07 29.5 0.1 4.7e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Transport protein Avl9 DENN PF02141.21 PIK48025.1 - 4.6e-05 23.4 0.2 0.00032 20.7 0.2 2.3 1 1 0 1 1 1 1 DENN (AEX-3) domain Afi1 PF07792.12 PIK48025.1 - 0.047 14.2 0.0 0.093 13.2 0.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking YAF2_RYBP PF17219.3 PIK48026.1 - 8.7e-15 54.0 2.8 1.7e-14 53.1 2.8 1.5 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif Peripla_BP_2 PF01497.18 PIK48027.1 - 1.3 8.5 11.3 0.029 13.9 0.8 2.7 2 0 0 2 2 2 0 Periplasmic binding protein EVC2_like PF12297.8 PIK48028.1 - 1.4e-33 116.2 1.5 1.9e-33 115.8 1.5 1.1 1 0 0 1 1 1 1 Ellis van Creveld protein 2 like protein Exonuc_VII_L PF02601.15 PIK48028.1 - 1.6 8.2 5.3 2.3 7.7 5.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit EVC2_like PF12297.8 PIK48029.1 - 4.2e-06 25.7 0.9 4.2e-06 25.7 0.9 4.3 1 1 3 4 4 4 1 Ellis van Creveld protein 2 like protein Branch PF02485.21 PIK48031.1 - 2.7e-14 53.3 0.1 3.7e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Methyltransf_11 PF08241.12 PIK48033.1 - 1.3e-17 64.2 0.0 1.9e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48033.1 - 3.8e-16 59.6 0.0 5.6e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK48033.1 - 6.8e-10 38.7 0.0 8.6e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK48033.1 - 4.2e-09 36.4 0.0 5.5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK48033.1 - 5.4e-09 36.0 0.0 8.1e-09 35.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48033.1 - 4.8e-08 33.7 0.0 7.9e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 PIK48033.1 - 3.1e-06 26.0 0.0 3.4e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 PIK48033.1 - 4e-05 23.3 0.0 5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 PIK48033.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 PIK48033.1 - 0.0025 17.4 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 PIK48033.1 - 0.0058 16.1 0.0 0.0073 15.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 PIK48033.1 - 0.015 15.3 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 PIK48033.1 - 0.033 13.9 0.1 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 DNA methylase ADH_zinc_N PF00107.26 PIK48033.1 - 0.036 14.1 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_PK PF05891.12 PIK48033.1 - 0.039 13.5 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase RrnaAD PF00398.20 PIK48033.1 - 0.11 11.5 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Abhydrolase_3 PF07859.13 PIK48036.1 - 2.9e-09 37.1 0.0 3.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 PIK48037.1 - 5.3e-28 98.3 0.0 9e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK48037.1 - 0.0016 17.4 0.0 0.0052 15.7 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK48037.1 - 0.0092 15.5 0.0 0.21 11.1 0.0 2.7 3 1 1 4 4 4 1 Prolyl oligopeptidase family Esterase PF00756.20 PIK48037.1 - 0.013 15.1 0.0 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 Putative esterase DUF3290 PF11694.8 PIK48037.1 - 0.044 13.7 1.3 0.079 12.9 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3290) Abhydrolase_3 PF07859.13 PIK48038.1 - 5.5e-41 140.7 0.0 2.8e-30 105.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK48038.1 - 0.0032 16.4 0.1 0.05 12.5 0.1 2.1 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK48038.1 - 0.0043 16.6 0.0 0.011 15.2 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family HSP20 PF00011.21 PIK48041.1 - 2e-21 76.1 0.1 4e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 PIK48041.1 - 0.00015 21.3 0.0 0.00026 20.5 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA ENTH PF01417.20 PIK48042.1 - 2.1e-43 147.3 0.1 3.4e-43 146.7 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 PIK48042.1 - 0.00039 19.5 0.5 0.0014 17.7 0.0 2.0 2 0 0 2 2 2 1 ANTH domain DNA_binding_1 PF01035.20 PIK48043.1 - 6.9e-27 93.4 0.0 1.1e-26 92.7 0.0 1.4 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MRP-S26 PF14943.6 PIK48044.1 - 1.4e-44 152.0 14.4 1.4e-44 152.0 14.4 1.9 2 0 0 2 2 2 1 Mitochondrial ribosome subunit S26 Iron_permease PF04120.12 PIK48044.1 - 0.093 12.5 0.5 0.093 12.5 0.5 2.1 2 1 1 3 3 3 0 Low affinity iron permease Cpn60_TCP1 PF00118.24 PIK48045.1 - 3.7e-120 401.8 6.2 4.6e-120 401.6 6.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family hNIFK_binding PF12196.8 PIK48046.1 - 0.1 12.1 4.2 4.5 6.9 0.3 2.9 1 1 1 2 2 2 0 FHA Ki67 binding domain of hNIFK HTH_22 PF13309.6 PIK48047.1 - 0.19 11.9 0.2 0.32 11.1 0.2 1.4 1 0 0 1 1 1 0 HTH domain ZU5 PF00791.20 PIK48049.1 - 1.9e-14 53.8 0.0 5e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK48049.1 - 3.2e-12 46.5 0.7 7e-12 45.4 0.7 1.5 1 0 0 1 1 1 1 Death domain CARD_2 PF16739.5 PIK48049.1 - 0.11 12.5 0.7 0.25 11.3 0.7 1.6 1 0 0 1 1 1 0 Caspase recruitment domain ZU5 PF00791.20 PIK48050.1 - 3.3e-09 37.0 0.1 1.1e-08 35.2 0.1 1.9 1 0 0 1 1 1 1 ZU5 domain TPR_MLP1_2 PF07926.12 PIK48050.1 - 0.0011 19.0 0.6 0.0029 17.7 0.6 1.7 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.7 PIK48050.1 - 4 7.6 11.9 0.29 11.3 6.0 2.1 2 0 0 2 2 2 0 Tropomyosin like RVT_1 PF00078.27 PIK48051.1 - 1.3e-43 149.0 1.4 1.2e-42 146.0 0.0 2.7 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK48051.1 - 1.7e-09 38.3 1.1 1.7e-09 38.3 1.1 3.2 4 0 0 4 4 4 1 zinc-binding in reverse transcriptase GPHR_N PF12537.8 PIK48053.1 - 7.8e-28 96.4 0.2 1.9e-27 95.1 0.2 1.7 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal ABA_GPCR PF12430.8 PIK48053.1 - 4.6e-24 85.2 8.7 2.8e-19 69.5 3.3 2.9 2 2 1 3 3 3 2 Abscisic acid G-protein coupled receptor SAM_1 PF00536.30 PIK48054.1 - 1.2e-18 67.3 0.1 2e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK48054.1 - 1.7e-17 63.3 0.1 2.7e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 PIK48054.1 - 0.00043 20.0 0.0 0.0014 18.4 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 PIK48054.1 - 0.0024 17.8 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK48054.1 - 0.019 14.9 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 PIK48054.1 - 0.025 14.8 0.1 0.045 14.0 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif POTRA_1 PF08478.10 PIK48055.1 - 0.11 12.8 0.1 2.4 8.5 0.0 2.3 2 0 0 2 2 2 0 POTRA domain, FtsQ-type DUF2045 PF09741.9 PIK48056.1 - 1.9e-47 161.6 0.7 5.5e-39 133.9 0.2 2.1 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2045) RVT_1 PF00078.27 PIK48057.1 - 6.8e-23 81.3 0.1 1.4e-22 80.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48057.1 - 9.9e-16 57.6 0.0 2.1e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48057.1 - 2.4e-09 37.4 0.0 3.3e-08 33.8 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 PIK48057.1 - 0.00018 21.4 11.4 0.0042 17.1 2.4 2.6 2 0 0 2 2 2 2 Zinc knuckle Retrotrans_gag PF03732.17 PIK48057.1 - 0.027 14.7 0.0 0.08 13.2 0.0 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC_3 PF13917.6 PIK48057.1 - 0.029 14.3 0.8 0.029 14.3 0.8 2.3 2 0 0 2 2 2 0 Zinc knuckle Sof1 PF04158.14 PIK48057.1 - 0.37 11.1 1.3 0.78 10.0 1.3 1.5 1 0 0 1 1 1 0 Sof1-like domain rve PF00665.26 PIK48058.1 - 1.9e-20 73.2 0.0 7e-20 71.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48058.1 - 3.1e-17 62.4 0.4 6.5e-17 61.4 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK48058.1 - 0.042 13.6 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain DUF1679 PF07914.11 PIK48058.1 - 0.074 11.9 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DDE_3 PF13358.6 PIK48058.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease UQ_con PF00179.26 PIK48059.1 - 0.00057 19.5 0.0 0.0007 19.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ldl_recept_b PF00058.17 PIK48060.1 - 6.2e-39 132.2 9.1 9.2e-15 54.9 0.1 5.4 5 1 0 5 5 5 5 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK48060.1 - 0.00016 21.4 4.3 0.27 10.8 0.0 4.1 2 1 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 PIK48060.1 - 0.0011 18.3 0.0 0.018 14.3 0.0 1.8 1 1 1 2 2 2 2 Domain of unknown function (DUF5050) FXa_inhibition PF14670.6 PIK48060.1 - 0.021 15.1 0.9 0.044 14.1 0.9 1.5 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site SL4P PF17618.2 PIK48060.1 - 0.19 11.8 0.3 27 4.9 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein Ldl_recept_b PF00058.17 PIK48061.1 - 1.7e-24 86.0 3.4 8.1e-12 45.4 0.0 2.8 3 0 0 3 3 3 2 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK48061.1 - 0.00059 19.5 0.2 0.0018 17.9 0.2 1.7 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_a PF00057.18 PIK48062.1 - 1.7e-28 98.5 42.3 1.9e-10 40.8 12.4 4.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK48062.1 - 3.8e-18 65.7 10.2 0.05 14.1 0.0 6.9 6 1 0 6 6 6 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK48062.1 - 5e-14 52.3 25.2 1.2e-08 35.1 9.3 5.1 6 0 0 6 6 6 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK48062.1 - 0.01 15.8 1.5 0.01 15.8 1.5 3.5 3 0 0 3 3 3 0 Complement Clr-like EGF-like EGF PF00008.27 PIK48062.1 - 0.014 15.7 3.2 0.014 15.7 3.2 5.0 5 0 0 5 5 5 0 EGF-like domain Peptidase_M16_C PF05193.21 PIK48063.1 - 8.7e-07 29.1 0.1 0.0058 16.7 0.0 3.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain M16C_assoc PF08367.11 PIK48063.1 - 0.00058 19.1 8.4 0.17 11.0 0.1 3.5 3 0 0 3 3 3 3 Peptidase M16C associated DUF2205 PF10224.9 PIK48063.1 - 0.21 11.6 2.9 0.6 10.1 2.9 1.8 1 0 0 1 1 1 0 Short coiled-coil protein BTB_2 PF02214.22 PIK48064.1 - 2.3e-30 104.8 0.0 3.5e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 PIK48064.1 - 0.00051 20.1 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain SdpA PF17418.2 PIK48064.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Sporulation delaying protein SdpA Ion_trans PF00520.31 PIK48065.1 - 2.1e-41 141.8 3.0 2.5e-41 141.5 3.0 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK48065.1 - 9.9e-12 44.7 2.1 9.9e-12 44.7 2.1 2.3 2 1 0 2 2 2 1 Ion channel DUF3185 PF11381.8 PIK48065.1 - 0.0014 18.6 2.9 0.0032 17.5 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3185) TraG_N PF07916.11 PIK48065.1 - 0.04 12.8 1.0 0.057 12.3 0.2 1.6 1 1 1 2 2 2 0 TraG-like protein, N-terminal region PGPGW PF09656.10 PIK48065.1 - 0.53 9.8 8.6 5.5 6.6 4.6 2.5 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) SIKE PF05769.11 PIK48066.1 - 4.2e-12 46.4 6.8 4.2e-12 46.4 6.8 1.6 2 0 0 2 2 2 1 SIKE family Fib_alpha PF08702.10 PIK48066.1 - 0.074 13.2 2.8 0.15 12.3 2.8 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Muted PF14942.6 PIK48066.1 - 0.52 10.6 6.1 1.1 9.6 6.0 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Homeodomain PF00046.29 PIK48067.1 - 9.5e-21 73.4 3.5 1.7e-20 72.6 3.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK48067.1 - 0.014 15.3 0.2 0.028 14.3 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 PIK48067.1 - 0.077 12.5 0.3 0.18 11.3 0.3 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez DUF2986 PF11661.8 PIK48067.1 - 0.078 13.5 1.0 0.078 13.5 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) YdaS_antitoxin PF15943.5 PIK48067.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT WW PF00397.26 PIK48068.1 - 2.1e-13 50.1 0.5 2.7e-06 27.4 0.1 2.1 2 0 0 2 2 2 2 WW domain Peptidase_M16 PF00675.20 PIK48069.1 - 4.4e-44 150.1 0.1 6.3e-44 149.6 0.1 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 PIK48069.1 - 3.3e-14 53.3 0.0 1.1e-13 51.6 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain MCM_bind PF09739.9 PIK48070.1 - 1.8e-42 145.6 0.2 2.1e-42 145.3 0.2 1.1 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor MCM_bind PF09739.9 PIK48071.1 - 1.7e-130 436.2 3.8 6.3e-99 332.0 5.1 2.0 2 0 0 2 2 2 2 Mini-chromosome maintenance replisome factor Defensin_4 PF07936.12 PIK48071.1 - 0.036 13.9 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 Potassium-channel blocking toxin DUF3427 PF11907.8 PIK48071.1 - 0.12 11.6 2.8 1.1 8.5 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3427) ATP-cone PF03477.16 PIK48071.1 - 0.13 12.9 0.1 0.33 11.6 0.1 1.7 1 0 0 1 1 1 0 ATP cone domain Pkinase PF00069.25 PIK48072.1 - 4.8e-16 58.9 0.1 6.1e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48072.1 - 1.3e-08 34.5 0.0 1.6e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK48072.1 - 0.0023 16.8 0.0 0.0031 16.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK48072.1 - 0.026 13.5 0.1 0.037 13.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 PIK48072.1 - 0.043 13.2 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK48072.1 - 0.078 12.9 0.2 0.29 11.0 0.2 1.7 1 1 0 2 2 2 0 Phosphotransferase enzyme family SUV3_C PF12513.8 PIK48074.1 - 6.6e-16 58.0 0.1 1.3e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 PIK48074.1 - 1.1e-15 57.2 0.5 1.9e-15 56.4 0.5 1.4 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 PIK48074.1 - 1.5e-06 28.5 0.0 3.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ALMS_motif PF15309.6 PIK48079.1 - 6e-31 107.7 14.3 6e-31 107.7 14.3 3.9 4 1 0 4 4 4 1 ALMS motif DUF630 PF04783.12 PIK48079.1 - 0.1 12.8 0.3 0.28 11.4 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF630) 7tm_1 PF00001.21 PIK48080.1 - 1.9e-24 86.4 2.6 2.2e-24 86.2 2.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK48080.1 - 4.3e-05 23.0 12.5 6.6e-05 22.4 12.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK48080.1 - 0.00011 22.0 3.9 0.0002 21.2 3.9 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK48080.1 - 0.00081 19.1 16.8 0.0012 18.5 16.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_L33 PF00471.20 PIK48081.1 - 0.044 14.2 0.5 0.11 13.0 0.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L33 Tsc35 PF15079.6 PIK48081.1 - 0.45 10.1 5.2 2 7.9 0.7 2.2 2 0 0 2 2 2 0 Testis-specific protein 35 NHL PF01436.21 PIK48082.1 - 1.5e-17 62.6 5.4 2.8e-07 30.2 0.3 4.8 4 0 0 4 4 4 2 NHL repeat SGL PF08450.12 PIK48082.1 - 1.3e-06 28.2 0.5 0.00095 18.8 0.0 2.9 2 1 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 PIK48082.1 - 9.4e-06 25.5 0.4 0.14 12.2 0.3 2.5 2 0 0 2 2 2 2 Beta-propeller repeat zf-C3HC4 PF00097.25 PIK48082.1 - 2.2e-05 24.2 14.6 2.2e-05 24.2 14.6 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK48082.1 - 5.7e-05 22.9 11.6 5.7e-05 22.9 11.6 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48082.1 - 7e-05 23.1 13.7 7e-05 23.1 13.7 2.8 2 0 0 2 2 1 1 Ring finger domain DUF5128 PF17170.4 PIK48082.1 - 0.00024 20.4 0.1 0.007 15.6 0.1 2.8 3 0 0 3 3 3 1 6-bladed beta-propeller zf-RING_UBOX PF13445.6 PIK48082.1 - 0.00033 20.6 11.6 0.00033 20.6 11.6 2.2 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK48082.1 - 0.00079 19.2 14.7 0.00079 19.2 14.7 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Filamin PF00630.19 PIK48082.1 - 0.0042 17.9 0.0 0.015 16.1 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-C3HC4_4 PF15227.6 PIK48082.1 - 0.0091 16.1 14.4 0.0091 16.1 14.4 2.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING CREPT PF16566.5 PIK48082.1 - 0.019 15.1 2.0 0.043 14.0 2.0 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Myosin_TH1 PF06017.13 PIK48082.1 - 0.069 12.8 0.6 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Unconventional myosin tail, actin- and lipid-binding Baculo_PEP_C PF04513.12 PIK48082.1 - 0.11 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Arylesterase PF01731.20 PIK48082.1 - 0.12 12.6 0.0 0.45 10.8 0.0 2.0 1 0 0 1 1 1 0 Arylesterase RPN7 PF10602.9 PIK48082.1 - 0.14 11.8 3.1 0.17 11.6 0.9 2.0 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TENA_THI-4 PF03070.16 PIK48082.1 - 0.44 10.3 3.8 0.61 9.9 2.1 2.1 2 1 1 3 3 3 0 TENA/THI-4/PQQC family DUF1664 PF07889.12 PIK48082.1 - 0.48 10.5 1.8 0.96 9.5 1.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) zf-CCHC_3 PF13917.6 PIK48082.1 - 3 7.9 8.7 0.68 9.9 1.5 2.6 1 1 1 2 2 2 0 Zinc knuckle WD40 PF00400.32 PIK48083.1 - 2.7e-10 40.7 5.1 0.3 12.0 0.2 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48083.1 - 0.0037 17.5 0.0 2.1 8.7 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PALP PF00291.25 PIK48084.1 - 1e-10 41.5 0.0 1.2e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glyco_transf_56 PF07429.11 PIK48084.1 - 0.18 10.9 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 HyaE PF07449.11 PIK48085.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE PALP PF00291.25 PIK48085.1 - 0.15 11.5 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme PKK PF12474.8 PIK48086.1 - 5.6e-18 65.4 35.6 5.6e-18 65.4 35.6 2.2 1 1 1 2 2 2 1 Polo kinase kinase PKK PF12474.8 PIK48087.1 - 1.8e-17 63.8 46.6 1.8e-17 63.8 46.6 2.2 2 0 0 2 2 2 1 Polo kinase kinase DNAJ_related PF12339.8 PIK48087.1 - 0.0023 18.2 2.5 0.0023 18.2 2.5 2.2 2 0 0 2 2 2 1 DNA-J related protein ALMT PF11744.8 PIK48087.1 - 2.4 6.9 25.1 2.9 6.6 25.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MMU163 PF17119.5 PIK48087.1 - 9.7 5.3 15.4 2.6 7.1 12.2 1.6 1 1 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Pkinase PF00069.25 PIK48088.1 - 1.7e-05 24.4 0.1 2.2e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain ATF7IP_BD PF16788.5 PIK48088.1 - 0.4 10.8 3.6 0.69 10.0 3.6 1.4 1 0 0 1 1 1 0 ATF-interacting protein binding domain Pkinase PF00069.25 PIK48089.1 - 1.3e-18 67.3 0.3 1.6e-18 67.0 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48089.1 - 2.1e-12 46.9 0.2 2.4e-12 46.7 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase MA3 PF02847.17 PIK48090.1 - 2.7e-30 104.7 0.8 8.5e-19 67.6 0.0 2.3 2 0 0 2 2 2 2 MA3 domain DUF4500 PF14937.6 PIK48091.1 - 3.3e-31 107.1 0.1 4.2e-31 106.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) DUF533 PF04391.12 PIK48091.1 - 0.084 12.4 0.0 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) HHH_8 PF14716.6 PIK48092.1 - 3.7e-07 30.4 0.3 9.6e-07 29.1 0.1 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain TMEM215 PF15746.5 PIK48092.1 - 0.061 12.8 1.7 0.076 12.5 1.7 1.1 1 0 0 1 1 1 0 TMEM215 family DHH PF01368.20 PIK48092.1 - 0.074 13.3 0.2 0.093 13.0 0.2 1.3 1 0 0 1 1 1 0 DHH family DNA_pol_lambd_f PF10391.9 PIK48093.1 - 1.7e-18 66.2 0.0 2.9e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 PIK48093.1 - 4.8e-11 42.9 0.0 7.8e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase beta palm NTP_transf_2 PF01909.23 PIK48093.1 - 0.002 18.4 0.0 0.0032 17.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cdd1 PF11731.8 PIK48093.1 - 0.074 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Pathogenicity locus RCC1 PF00415.18 PIK48094.1 - 4e-32 110.6 8.6 7.2e-10 39.3 0.1 5.9 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK48094.1 - 5.4e-23 80.2 9.9 1.1e-07 31.5 0.8 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DNA_pol_lambd_f PF10391.9 PIK48095.1 - 4.7e-20 71.1 0.2 4.3e-19 68.1 0.1 2.3 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 PIK48095.1 - 3.4e-19 69.1 0.0 6.5e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 PIK48095.1 - 1.1e-18 67.4 0.1 4.2e-18 65.5 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.8 PIK48095.1 - 2.2e-05 24.6 0.0 0.0025 18.0 0.0 2.8 2 1 1 3 3 3 1 Pathogenicity locus HHH_5 PF14520.6 PIK48095.1 - 0.00081 20.0 0.0 1.5 9.5 0.0 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix domain IMS_HHH PF11798.8 PIK48095.1 - 0.0012 19.1 0.0 2.7 8.5 0.0 2.7 2 0 0 2 2 2 2 IMS family HHH motif P33MONOX PF15302.6 PIK48095.1 - 0.019 14.7 0.4 0.025 14.3 0.4 1.1 1 0 0 1 1 1 0 P33 mono-oxygenase HHH_2 PF12826.7 PIK48095.1 - 0.022 14.8 0.0 2.7 8.2 0.0 2.5 1 1 1 2 2 2 0 Helix-hairpin-helix motif HHH_3 PF12836.7 PIK48095.1 - 0.043 14.1 0.5 1.8 8.9 0.0 3.0 4 0 0 4 4 4 0 Helix-hairpin-helix motif HHH PF00633.23 PIK48095.1 - 0.057 13.3 0.1 4.1 7.4 0.1 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif zf-C2H2_2 PF12756.7 PIK48095.1 - 0.072 13.4 0.1 1 9.7 0.0 2.4 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Transketolase_C PF02780.20 PIK48095.1 - 0.18 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Transketolase, C-terminal domain Pkinase PF00069.25 PIK48096.1 - 1.5e-39 135.9 0.1 6.7e-21 74.8 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48096.1 - 6.6e-26 91.1 0.3 4.6e-16 58.9 0.2 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Sulfatase PF00884.23 PIK48097.1 - 4.7e-58 197.0 0.0 1.2e-46 159.6 0.0 2.1 1 1 1 2 2 2 2 Sulfatase Sulfatase_C PF14707.6 PIK48097.1 - 4.4e-19 69.4 0.1 1e-18 68.2 0.1 1.6 2 0 0 2 2 2 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK48097.1 - 0.0002 21.1 0.0 0.00091 18.9 0.0 1.9 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK48097.1 - 0.034 12.8 0.0 0.041 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Collagen PF01391.18 PIK48098.1 - 1.3 8.8 14.5 0.59 9.9 7.2 2.3 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) ABC_tran_CTD PF16326.5 PIK48099.1 - 0.088 13.1 0.2 0.15 12.3 0.2 1.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain Collagen PF01391.18 PIK48099.1 - 0.63 9.8 8.2 2.2 8.1 8.2 1.9 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) FH2 PF02181.23 PIK48101.1 - 7e-64 216.3 3.6 7e-64 216.3 3.6 2.0 2 0 0 2 2 2 1 Formin Homology 2 Domain UQ_con PF00179.26 PIK48102.1 - 1.1e-47 161.2 0.0 1.3e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme INTS2 PF14750.6 PIK48103.1 - 4e-76 256.5 2.0 4e-76 256.5 2.0 1.6 2 0 0 2 2 2 1 Integrator complex subunit 2 Corona_7 PF02398.16 PIK48103.1 - 0.064 13.8 0.1 0.71 10.5 0.1 2.3 2 0 0 2 2 2 0 Coronavirus protein 7 INTS2 PF14750.6 PIK48104.1 - 1.8e-281 936.3 6.6 2.5e-281 935.9 6.6 1.1 1 0 0 1 1 1 1 Integrator complex subunit 2 SK_channel PF03530.14 PIK48104.1 - 0.66 10.0 3.6 0.59 10.1 0.4 2.5 2 1 0 2 2 2 0 Calcium-activated SK potassium channel PID_2 PF14719.6 PIK48105.1 - 0.00019 21.3 0.0 0.00051 20.0 0.0 1.7 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Tcp10_C PF07202.13 PIK48106.1 - 2.4e-83 278.4 3.0 2.4e-83 278.4 3.0 2.6 2 1 1 3 3 3 1 T-complex protein 10 C-terminus bZIP_1 PF00170.21 PIK48106.1 - 0.0096 16.0 2.8 0.0096 16.0 2.8 4.0 1 1 3 4 4 2 1 bZIP transcription factor MORN_2 PF07661.13 PIK48106.1 - 0.012 15.7 0.1 77 4.0 0.0 5.3 5 0 0 5 5 5 0 MORN repeat variant DUF4520 PF15016.6 PIK48106.1 - 0.046 13.8 0.0 3.9 7.6 0.0 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4520) EndoU_bacteria PF14436.6 PIK48106.1 - 0.36 11.2 8.7 18 5.7 0.8 4.2 4 0 0 4 4 4 0 Bacterial EndoU nuclease Lyase_1 PF00206.20 PIK48106.1 - 0.41 10.0 5.6 0.59 9.5 5.6 1.1 1 0 0 1 1 1 0 Lyase Shugoshin_N PF07558.11 PIK48106.1 - 0.52 10.2 3.9 2 8.4 0.1 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region SOAR PF16533.5 PIK48106.1 - 2.1 8.4 19.0 0.053 13.5 11.5 2.2 2 1 0 2 2 2 0 STIM1 Orai1-activating region TSC22 PF01166.18 PIK48106.1 - 3.8 7.9 13.8 16 5.9 0.9 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family Exonuc_VII_L PF02601.15 PIK48106.1 - 4.5 6.7 14.4 8.2 5.9 14.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 PIK48106.1 - 4.9 4.9 15.1 9 4.1 15.1 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-K PF11802.8 PIK48106.1 - 7.5 6.0 25.9 22 4.5 25.9 1.7 1 1 0 1 1 1 0 Centromere-associated protein K MORN PF02493.20 PIK48108.1 - 8.6e-29 97.7 35.8 7e-05 22.5 1.4 7.3 7 0 0 7 7 7 6 MORN repeat PHD_4 PF16866.5 PIK48109.1 - 5.8e-18 64.7 9.0 5.8e-18 64.7 9.0 2.7 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.20 PIK48109.1 - 2e-13 50.1 23.0 2e-13 50.1 23.0 2.9 2 1 0 2 2 2 1 CXXC zinc finger domain F-box-like PF12937.7 PIK48109.1 - 1.1e-06 28.5 1.3 2.6e-06 27.2 1.3 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 PIK48109.1 - 1e-05 25.2 11.5 0.03 14.4 0.3 5.1 5 0 0 5 5 5 2 Leucine Rich repeat F-box PF00646.33 PIK48109.1 - 4.6e-05 23.2 0.1 0.00013 21.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain PHD PF00628.29 PIK48109.1 - 4.8e-05 23.2 7.7 4.8e-05 23.2 7.7 2.9 2 0 0 2 2 2 1 PHD-finger LRR_4 PF12799.7 PIK48109.1 - 0.00024 21.4 6.0 3.4 8.2 0.2 4.7 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK48109.1 - 0.021 14.6 5.7 0.067 13.0 1.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.33 PIK48109.1 - 4.5 8.2 12.1 83 4.4 0.0 6.0 6 1 0 6 6 6 0 Leucine Rich Repeat Orai-1 PF07856.12 PIK48110.1 - 1.2e-58 197.7 7.0 1.4e-58 197.5 7.0 1.0 1 0 0 1 1 1 1 Mediator of CRAC channel activity O_anti_polymase PF01901.16 PIK48110.1 - 0.009 15.3 4.9 0.011 15.0 4.9 1.1 1 0 0 1 1 1 1 Putative O-antigen polymerase TadE PF07811.12 PIK48110.1 - 0.33 11.3 0.3 0.33 11.3 0.3 2.8 3 0 0 3 3 3 0 TadE-like protein Neurensin PF14927.6 PIK48110.1 - 1.2 8.8 6.8 1.2 8.8 4.3 2.2 1 1 1 2 2 2 0 Neurensin PHO4 PF01384.20 PIK48110.1 - 4.9 6.1 5.8 7.4 5.5 5.8 1.3 1 1 0 1 1 1 0 Phosphate transporter family Ras PF00071.22 PIK48111.1 - 5e-55 185.5 0.6 6.2e-55 185.2 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK48111.1 - 9e-30 103.4 0.7 2e-29 102.3 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK48111.1 - 1.1e-14 54.3 0.3 1.6e-14 53.7 0.3 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK48111.1 - 2e-05 24.2 0.3 4.1e-05 23.2 0.3 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK48111.1 - 0.0017 18.4 0.3 0.004 17.2 0.1 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK48111.1 - 0.007 15.9 0.2 0.016 14.7 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK48111.1 - 0.036 14.0 0.3 0.15 11.9 0.1 2.0 1 1 1 2 2 2 0 RsgA GTPase SAM_2 PF07647.17 PIK48112.1 - 3.4e-17 62.3 1.4 2.9e-11 43.3 0.0 3.0 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK48112.1 - 1.5e-14 54.2 0.5 2.8e-09 37.3 0.0 2.7 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) TIR_2 PF13676.6 PIK48112.1 - 4.7e-11 43.3 0.0 8.4e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain Peptidase_M24_C PF16188.5 PIK48112.1 - 0.067 13.3 0.1 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 C-terminal region of peptidase_M24 SH3_9 PF14604.6 PIK48114.1 - 1.9e-40 136.5 0.3 2.7e-16 59.1 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 PIK48114.1 - 1.9e-37 126.7 2.8 1e-12 47.5 0.0 3.7 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.17 PIK48114.1 - 7.6e-31 105.6 0.1 7.3e-11 41.6 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.16 PIK48114.1 - 6.8e-21 73.9 1.6 1.9e-20 72.5 1.6 1.8 1 0 0 1 1 1 1 Sorbin homologous domain Peptidase_M14 PF00246.24 PIK48117.1 - 2.6e-50 171.9 0.4 5.2e-50 170.9 0.1 1.5 2 0 0 2 2 2 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 PIK48117.1 - 2.3e-13 50.2 0.0 3.8e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 PIK48117.1 - 4.1e-07 29.9 0.0 7.6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 PIK48117.1 - 0.25 10.4 0.5 0.47 9.5 0.5 1.4 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Sigma_reg_N PF13800.6 PIK48118.1 - 0.014 15.7 0.7 5.6 7.3 0.0 3.0 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Phage_TAC_4 PF08748.11 PIK48118.1 - 0.27 11.6 2.6 11 6.3 0.1 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone Alg14 PF08660.11 PIK48118.1 - 0.29 11.0 6.8 4.5 7.2 1.1 2.5 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like Methyltransf_32 PF13679.6 PIK48118.1 - 0.68 9.9 6.3 1.4 8.9 0.2 2.4 2 0 0 2 2 2 0 Methyltransferase domain RibD_C PF01872.17 PIK48118.1 - 0.72 9.6 11.6 1.7 8.4 2.2 2.3 2 0 0 2 2 2 0 RibD C-terminal domain Mcm10 PF09332.11 PIK48118.1 - 2.2 7.7 20.2 1.5 8.1 5.4 2.3 2 0 0 2 2 2 0 Mcm10 replication factor DUF5462 PF17547.2 PIK48118.1 - 2.3 7.6 8.6 0.07 12.5 0.6 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5462) XRN1_D2_D3 PF18334.1 PIK48118.1 - 4 7.7 7.8 12 6.2 0.2 3.5 4 2 1 5 5 5 0 Exoribonuclease Xrn1 D2/D3 domain 7tm_1 PF00001.21 PIK48119.1 - 2.9e-30 105.5 11.3 3.9e-30 105.1 11.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FAD_binding_8 PF08022.12 PIK48120.1 - 2.7e-17 62.8 0.0 5e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 PIK48120.1 - 5.8e-08 32.9 0.0 9.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_1 PF00036.32 PIK48121.1 - 1.1e-14 52.8 9.7 3.1e-06 26.3 0.2 4.5 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 PIK48121.1 - 8.6e-12 45.3 9.7 1.3e-07 32.0 1.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK48121.1 - 4e-11 41.9 5.2 4.2e-05 23.1 0.1 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 PIK48121.1 - 1.4e-08 33.8 3.9 0.0026 17.2 0.3 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK48121.1 - 5.7e-07 29.3 7.5 0.0044 16.9 0.9 4.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 PIK48121.1 - 0.003 17.5 2.8 1.7 8.6 0.2 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK48121.1 - 0.0036 17.6 1.4 1.3 9.4 0.1 2.7 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region SMC_Nse1 PF07574.13 PIK48121.1 - 0.013 15.4 1.3 0.023 14.6 0.3 1.8 1 1 1 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex EF-hand_9 PF14658.6 PIK48121.1 - 0.027 14.8 0.1 0.89 9.9 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain CRF PF00473.17 PIK48121.1 - 0.077 13.1 0.3 0.27 11.3 0.3 2.0 1 0 0 1 1 1 0 Corticotropin-releasing factor family An_peroxidase PF03098.15 PIK48122.1 - 1e-62 212.4 0.1 1.2e-62 212.2 0.1 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Inositol_P PF00459.25 PIK48123.1 - 6.3e-41 140.7 0.5 9.6e-41 140.1 0.5 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family Glyco_transf_10 PF00852.19 PIK48124.1 - 3.1e-47 160.6 0.1 4.9e-47 159.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK48124.1 - 3.9e-07 30.5 0.0 7e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Fibrinogen_C PF00147.18 PIK48125.1 - 1.4e-62 211.4 5.6 1.2e-38 133.2 0.2 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK48125.1 - 1.2e-06 28.6 6.0 1.2e-06 28.6 6.0 3.6 4 0 0 4 4 4 2 EGF domain TILa PF12714.7 PIK48125.1 - 0.00078 19.3 3.7 0.00078 19.3 3.7 3.5 1 1 1 2 2 2 1 TILa domain TIL PF01826.17 PIK48125.1 - 0.0026 18.0 11.7 0.0026 18.0 11.7 3.2 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF PF00008.27 PIK48125.1 - 0.036 14.4 11.7 0.39 11.1 2.4 3.7 2 1 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK48125.1 - 0.12 12.5 16.4 0.32 11.1 3.4 3.1 2 0 0 2 2 2 0 MSP1 EGF domain 1 cEGF PF12662.7 PIK48125.1 - 0.24 11.3 0.2 0.24 11.3 0.2 4.9 6 0 0 6 6 6 0 Complement Clr-like EGF-like XendoU PF09412.10 PIK48126.1 - 6.6e-103 343.5 0.4 7.5e-103 343.3 0.4 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU Pepdidase_M14_N PF18027.1 PIK48127.1 - 2e-12 47.4 0.1 4.6e-12 46.3 0.1 1.6 1 1 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 PIK48127.1 - 2.2e-10 40.8 0.0 4.2e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase zf-C2HC PF01530.18 PIK48127.1 - 0.018 15.2 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Zinc finger, C2HC type TBP PF00352.21 PIK48130.1 - 2.2e-26 91.6 0.2 3.6e-22 78.1 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) STALD PF18185.1 PIK48130.1 - 0.026 13.9 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family DUF3378 PF11858.8 PIK48130.1 - 0.037 14.1 0.3 0.079 13.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) Geminin PF07412.12 PIK48131.1 - 6.8e-18 65.1 23.7 7.4e-17 61.7 21.6 2.4 1 1 0 1 1 1 1 Geminin Nup188 PF10487.9 PIK48131.1 - 0.068 11.1 2.0 0.09 10.7 2.0 1.1 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 LMBR1 PF04791.16 PIK48131.1 - 3.8 6.3 4.6 4.2 6.2 4.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM167 PF11652.8 PIK48132.1 - 0.072 13.6 0.8 0.25 11.9 0.1 2.1 2 1 1 3 3 3 0 FAM167 ZapB PF06005.12 PIK48132.1 - 0.1 13.0 2.5 1.4 9.5 0.1 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Prefoldin_2 PF01920.20 PIK48132.1 - 0.1 12.5 0.3 3 7.9 0.0 2.1 2 0 0 2 2 2 0 Prefoldin subunit Cyclin_N PF00134.23 PIK48135.1 - 2.6e-11 43.4 0.1 3.9e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Sugar_tr PF00083.24 PIK48137.1 - 3.2e-24 85.6 1.8 3.2e-24 85.6 1.8 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK48137.1 - 3.8e-21 75.4 15.1 1.6e-20 73.3 5.7 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 PIK48137.1 - 1.7e-06 26.9 12.1 4.9e-06 25.4 4.2 3.0 3 0 0 3 3 3 2 MFS/sugar transport protein EF-hand_6 PF13405.6 PIK48138.1 - 2.8e-07 29.9 6.8 0.0015 18.3 0.2 4.4 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 PIK48138.1 - 5.9e-07 29.8 19.4 0.0004 20.8 3.3 4.6 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK48138.1 - 8.2e-07 28.8 7.8 1.2e-05 25.0 0.0 4.1 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK48138.1 - 1.1e-06 27.8 10.9 0.0017 17.7 0.4 4.7 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 PIK48138.1 - 0.00038 19.8 4.0 0.056 13.0 0.2 3.0 2 0 0 2 2 2 2 EF hand Cullin_binding PF03556.15 PIK48138.1 - 0.077 13.4 2.2 0.29 11.6 0.8 2.1 1 1 1 2 2 2 0 Cullin binding Zip PF02535.22 PIK48139.1 - 8.4e-35 120.6 3.2 1.1e-34 120.2 3.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF1240 PF06836.12 PIK48139.1 - 0.024 15.2 2.2 3.3 8.3 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) VMA21 PF09446.10 PIK48140.1 - 4.2e-12 46.0 14.3 5.8e-12 45.5 14.3 1.2 1 0 0 1 1 1 1 VMA21-like domain BCD PF15461.6 PIK48140.1 - 0.0031 17.0 0.5 0.004 16.7 0.5 1.1 1 0 0 1 1 1 1 Beta-carotene 15,15'-dioxygenase DUF1282 PF06930.12 PIK48140.1 - 0.0083 15.9 2.4 0.014 15.2 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) DUF2207 PF09972.9 PIK48140.1 - 0.027 13.2 0.5 0.03 13.1 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4282 PF14110.6 PIK48140.1 - 1.6 9.5 9.0 2.9 8.7 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) EF-hand_7 PF13499.6 PIK48141.1 - 1.9e-19 69.8 0.7 1.7e-10 41.2 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK48141.1 - 2.2e-17 61.4 1.1 2.7e-06 26.8 0.2 3.5 3 1 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 PIK48141.1 - 1.9e-14 52.0 5.2 2.6e-05 23.4 0.1 4.0 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 PIK48141.1 - 3.2e-12 46.1 2.2 0.00047 19.9 0.1 3.9 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK48141.1 - 2.9e-10 39.2 8.8 0.00067 19.0 0.0 3.6 3 1 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 PIK48141.1 - 4.8e-06 26.8 0.0 0.0053 17.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 PIK48141.1 - 0.014 15.4 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) tRNA-synt_1 PF00133.22 PIK48142.1 - 4.3e-20 71.5 0.0 2e-13 49.5 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 PIK48142.1 - 6.7e-14 52.1 0.0 1.7e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 PIK48142.1 - 1.4e-09 37.3 0.0 1.3e-08 34.0 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 PIK48142.1 - 2.4e-07 30.4 0.0 5.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 PIK48143.1 - 5.6e-05 21.6 0.1 7.2e-05 21.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 PIK48143.1 - 0.029 13.1 0.0 0.042 12.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (M) IF3_C PF00707.22 PIK48144.1 - 1.4e-10 41.0 1.3 2.9e-10 40.0 1.3 1.6 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 PIK48144.1 - 7.1e-09 35.8 0.2 2.3e-08 34.2 0.1 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain Peptidase_M10 PF00413.24 PIK48146.1 - 4.5e-49 166.3 0.2 6.4e-49 165.8 0.2 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 PIK48146.1 - 1.8e-05 24.8 0.0 4.6e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 PIK48146.1 - 0.0027 18.2 0.5 0.0057 17.2 0.5 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 PIK48146.1 - 0.0049 16.9 0.1 0.009 16.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M54 DUF4953 PF16313.5 PIK48146.1 - 0.0071 15.6 0.3 0.019 14.2 0.1 1.8 2 0 0 2 2 2 1 Met-zincin Reprolysin_5 PF13688.6 PIK48146.1 - 0.024 14.8 0.1 0.037 14.2 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 PIK48146.1 - 0.025 13.5 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 PIK48146.1 - 0.035 12.7 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Astacin PF01400.24 PIK48146.1 - 0.14 11.7 0.3 0.68 9.5 0.1 2.0 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 PIK48147.1 - 4.5e-49 166.3 0.2 6.4e-49 165.8 0.2 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 PIK48147.1 - 1.8e-05 24.8 0.0 4.6e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 PIK48147.1 - 0.0026 18.3 0.5 0.0057 17.2 0.5 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 PIK48147.1 - 0.005 16.8 0.1 0.009 16.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M54 DUF4953 PF16313.5 PIK48147.1 - 0.0072 15.6 0.3 0.019 14.2 0.1 1.8 2 0 0 2 2 2 1 Met-zincin Reprolysin_5 PF13688.6 PIK48147.1 - 0.024 14.8 0.1 0.037 14.2 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 PIK48147.1 - 0.025 13.5 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 PIK48147.1 - 0.035 12.7 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_4 PF13583.6 PIK48147.1 - 0.12 11.9 0.1 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 PIK48147.1 - 0.15 11.7 0.3 0.68 9.5 0.1 2.0 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 PIK48148.1 - 3.5e-39 134.2 0.1 9e-39 132.9 0.0 1.8 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.19 PIK48148.1 - 0.0034 17.3 7.5 0.2 11.6 0.0 4.1 5 0 0 5 5 5 2 Hemopexin Reprolysin_4 PF13583.6 PIK48148.1 - 0.0051 16.5 0.0 0.0098 15.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 PIK48148.1 - 0.0094 15.6 0.1 0.77 9.3 0.1 2.3 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Metallopep PF12044.8 PIK48148.1 - 0.026 13.2 0.0 0.038 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.9 PIK48148.1 - 0.045 12.7 0.1 0.075 12.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 PIK48148.1 - 0.045 14.3 0.0 0.099 13.2 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PG_binding_1 PF01471.18 PIK48148.1 - 0.053 13.7 0.2 0.12 12.6 0.2 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Reprolysin_5 PF13688.6 PIK48148.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 PIK48148.1 - 0.082 12.8 0.0 0.52 10.2 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M43 PF05572.13 PIK48148.1 - 0.084 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A DUF4953 PF16313.5 PIK48148.1 - 0.087 12.0 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 Met-zincin SH3_5 PF08460.10 PIK48148.1 - 0.096 12.8 0.1 20 5.4 0.0 2.6 2 0 0 2 2 2 0 Bacterial SH3 domain Peptidase_M10 PF00413.24 PIK48149.1 - 7.4e-59 198.1 0.0 1e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK48149.1 - 1.2e-33 114.8 8.5 4.9e-17 61.6 1.5 3.7 3 0 0 3 3 3 3 Hemopexin Astacin PF01400.24 PIK48149.1 - 0.00027 20.6 0.2 0.39 10.3 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.6 PIK48149.1 - 0.0032 17.7 0.4 0.0067 16.6 0.3 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK48149.1 - 0.0044 17.5 0.2 0.0077 16.7 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Trypan_PARP PF05887.11 PIK48149.1 - 0.0051 16.8 9.3 0.0079 16.2 9.3 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Peptidase_M66 PF10462.9 PIK48149.1 - 0.016 14.2 0.2 0.031 13.2 0.2 1.4 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.6 PIK48149.1 - 0.031 13.9 0.1 0.052 13.2 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK48149.1 - 0.047 12.9 0.3 0.074 12.2 0.3 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.8 PIK48149.1 - 0.07 12.7 0.7 0.11 12.0 0.7 1.4 1 1 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 PIK48149.1 - 0.13 12.2 0.0 2 8.3 0.0 2.1 2 0 0 2 2 2 0 Peptidase family M54 Metallopep PF12044.8 PIK48149.1 - 0.28 9.8 0.1 0.4 9.2 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family Tim17 PF02466.19 PIK48150.1 - 1.9e-34 118.4 1.6 2.4e-34 118.0 1.6 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Con-6 PF10346.9 PIK48150.1 - 0.1 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Conidiation protein 6 PSI PF01437.25 PIK48152.1 - 0.0014 19.1 12.4 0.0014 19.1 12.4 1.9 2 0 0 2 2 2 1 Plexin repeat Filamin PF00630.19 PIK48152.1 - 0.043 14.6 0.1 0.13 13.1 0.1 1.8 1 0 0 1 1 1 0 Filamin/ABP280 repeat PSI_integrin PF17205.3 PIK48152.1 - 0.098 12.4 11.7 0.24 11.2 11.7 1.7 1 0 0 1 1 1 0 Integrin plexin domain Apt1 PF10351.9 PIK48153.1 - 0.54 9.1 9.4 0.55 9.0 9.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 PIK48153.1 - 9.8 4.6 11.2 11 4.4 11.2 1.1 1 0 0 1 1 1 0 Macoilin family Ig_3 PF13927.6 PIK48154.1 - 0.0015 19.1 0.2 0.64 10.7 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK48154.1 - 0.14 12.3 0.1 2.7 8.1 0.0 2.7 3 0 0 3 3 3 0 Immunoglobulin I-set domain Cystatin PF00031.21 PIK48155.1 - 4.3e-08 33.3 0.1 5e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 Cystatin domain RVT_1 PF00078.27 PIK48156.1 - 0.0002 21.0 0.0 0.00024 20.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DEAD PF00270.29 PIK48158.1 - 9.9e-42 142.7 0.0 2.1e-41 141.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK48158.1 - 3.5e-22 78.8 0.1 2.6e-21 76.0 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK48158.1 - 7.1e-19 67.8 0.2 7.1e-19 67.8 0.2 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4217) ResIII PF04851.15 PIK48158.1 - 3.5e-06 27.1 0.0 6.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 PIK48158.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_22 PF13401.6 PIK48158.1 - 0.17 12.2 0.1 0.85 9.9 0.1 2.3 2 1 0 2 2 2 0 AAA domain DUF1409 PF07197.12 PIK48159.1 - 0.054 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) EMP24_GP25L PF01105.24 PIK48160.1 - 2.4e-47 161.3 0.1 3.2e-47 160.8 0.1 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DnaB_C PF03796.15 PIK48160.1 - 0.032 13.6 0.0 0.051 12.9 0.0 1.3 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain MAPEG PF01124.18 PIK48161.1 - 2.3e-06 27.5 0.3 2.3e-06 27.5 0.3 1.5 2 0 0 2 2 2 1 MAPEG family RT_RNaseH_2 PF17919.1 PIK48162.1 - 2.8e-24 85.0 0.0 7.5e-24 83.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48162.1 - 7.8e-20 71.2 0.0 1.8e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK48162.1 - 1e-18 67.6 0.0 2.4e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK48162.1 - 7.9e-16 57.9 0.4 2.6e-15 56.3 0.3 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK48162.1 - 1.9e-07 30.8 0.0 4.9e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 PIK48162.1 - 0.008 16.0 0.0 0.029 14.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase-like zf-H2C2 PF09337.10 PIK48162.1 - 0.017 15.3 0.1 0.041 14.1 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger MAPEG PF01124.18 PIK48163.1 - 4.8e-05 23.3 0.4 0.00011 22.1 0.3 1.6 2 0 0 2 2 2 1 MAPEG family BRICHOS PF04089.14 PIK48164.1 - 0.00026 21.2 0.0 0.00053 20.2 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain Hemerythrin PF01814.23 PIK48164.1 - 0.02 15.5 0.0 0.04 14.5 0.0 1.5 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain polyprenyl_synt PF00348.17 PIK48165.1 - 8.2e-90 300.3 0.2 1.1e-89 299.8 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Glyco_transf_10 PF00852.19 PIK48166.1 - 2e-44 151.4 0.3 3.1e-44 150.8 0.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK48166.1 - 7.8e-07 29.5 0.1 1.8e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal tRNA-synt_2d PF01409.20 PIK48166.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) DnaJ PF00226.31 PIK48167.1 - 1.1e-21 76.7 0.9 2.7e-21 75.5 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain Sec61_beta PF03911.16 PIK48167.1 - 0.017 15.1 0.2 0.034 14.2 0.2 1.4 1 0 0 1 1 1 0 Sec61beta family Trypan_PARP PF05887.11 PIK48168.1 - 0.0013 18.7 45.5 0.0013 18.7 45.5 4.3 1 1 2 3 3 3 1 Procyclic acidic repetitive protein (PARP) IPP-2 PF04979.14 PIK48169.1 - 1.6e-34 119.5 12.5 2.7e-34 118.8 12.5 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) THAP PF05485.12 PIK48170.1 - 3.4e-13 50.3 0.0 3.4e-13 50.3 0.0 2.4 2 1 0 2 2 2 1 THAP domain Trypsin_2 PF13365.6 PIK48171.1 - 1.3e-25 91.1 3.3 8.9e-23 81.9 0.3 3.0 2 1 0 2 2 2 2 Trypsin-like peptidase domain Nsp1_C PF05064.13 PIK48171.1 - 0.00047 19.9 0.9 0.0009 19.0 0.2 1.7 1 1 1 2 2 2 1 Nsp1-like C-terminal region Laminin_I PF06008.14 PIK48171.1 - 0.0092 15.7 3.2 0.022 14.5 0.8 1.9 1 1 1 2 2 2 1 Laminin Domain I CSN5_C PF18323.1 PIK48171.1 - 0.16 12.9 0.3 0.34 11.9 0.3 1.5 1 0 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain cNMP_binding PF00027.29 PIK48172.1 - 4.6e-36 122.8 0.0 1.3e-17 63.6 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Ion_trans PF00520.31 PIK48172.1 - 1.9e-21 76.5 52.2 5.6e-15 55.2 18.7 3.7 3 1 1 4 4 4 3 Ion transport protein Ion_trans_2 PF07885.16 PIK48172.1 - 4.3e-13 49.0 10.7 9.8e-09 35.1 2.1 4.1 5 1 0 5 5 5 2 Ion channel SPX PF03105.19 PIK48172.1 - 0.021 14.8 2.5 0.024 14.6 0.0 2.1 2 0 0 2 2 2 0 SPX domain cNMP_binding PF00027.29 PIK48173.1 - 3e-15 56.1 0.0 7e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 PIK48173.1 - 1.6e-13 50.4 15.0 2.1e-11 43.6 8.1 2.1 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 PIK48173.1 - 6.8e-07 29.2 5.4 6.8e-07 29.2 5.4 3.5 4 0 0 4 4 4 1 Ion channel DUF3410 PF11890.8 PIK48173.1 - 0.072 12.9 0.0 6.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) Ion_trans PF00520.31 PIK48174.1 - 3.1e-07 29.9 6.9 3.8e-07 29.6 6.9 1.0 1 0 0 1 1 1 1 Ion transport protein Smac_DIABLO PF09057.10 PIK48175.1 - 4.7e-16 58.8 5.3 5.7e-16 58.6 5.3 1.1 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases MafB PF06255.13 PIK48175.1 - 0.0081 15.6 0.0 0.0092 15.5 0.0 1.1 1 0 0 1 1 1 1 Neisseria toxin MafB PTPlike_phytase PF14566.6 PIK48175.1 - 0.033 14.3 0.4 0.068 13.3 0.2 1.6 1 1 0 1 1 1 0 Inositol hexakisphosphate PNMA PF14893.6 PIK48176.1 - 3.2e-09 36.7 0.1 3.4e-09 36.5 0.1 1.0 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK48176.1 - 0.016 15.5 0.0 0.17 12.2 0.0 2.3 1 1 1 2 2 2 0 Retrotransposon gag protein Bclx_interact PF08945.10 PIK48176.1 - 0.74 9.6 4.0 1.6 8.6 4.0 1.5 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain gag-asp_proteas PF13975.6 PIK48177.1 - 6.3e-05 23.5 0.0 0.00016 22.1 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK48177.1 - 0.016 15.8 0.4 0.071 13.8 0.3 2.2 2 1 0 2 2 2 0 Aspartyl protease Asp_protease PF09668.10 PIK48177.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK48178.1 - 1.9e-05 24.5 1.5 3.1e-05 23.8 1.5 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK48178.1 - 0.0071 16.0 2.6 0.013 15.2 2.6 1.4 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK48178.1 - 0.012 15.6 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK48178.1 - 0.021 14.6 2.1 0.043 13.6 2.1 1.5 1 0 0 1 1 1 0 Zinc knuckle Retrotrans_gag PF03732.17 PIK48178.1 - 0.023 15.0 0.1 0.091 13.0 0.0 2.2 3 0 0 3 3 3 0 Retrotransposon gag protein zf-C2HE PF16278.5 PIK48178.1 - 0.24 11.9 2.6 0.2 12.1 0.4 2.2 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4559 PF15112.6 PIK48178.1 - 0.3 10.7 3.9 0.44 10.2 1.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4559) BAR_3 PF16746.5 PIK48178.1 - 0.35 10.5 3.9 0.97 9.1 0.1 2.7 3 0 0 3 3 3 0 BAR domain of APPL family NPV_P10 PF05531.12 PIK48178.1 - 0.37 11.3 4.5 16 6.1 0.9 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein SKA2 PF16740.5 PIK48178.1 - 0.83 9.5 7.1 1.1 9.1 0.0 2.9 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 YabA PF06156.13 PIK48178.1 - 1.1 9.9 4.3 8.2 7.1 0.1 3.1 3 0 0 3 3 3 0 Initiation control protein YabA SlyX PF04102.12 PIK48178.1 - 1.3 9.6 11.3 5.4 7.7 1.0 3.2 3 0 0 3 3 3 0 SlyX 7tm_2 PF00002.24 PIK48180.1 - 9.9e-19 67.6 12.7 1.4e-18 67.1 12.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK48180.1 - 1.6e-14 54.2 5.3 2.8e-14 53.4 5.3 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RT_RNaseH_2 PF17919.1 PIK48181.1 - 2.5e-35 120.5 0.3 7.4e-35 119.0 0.1 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48181.1 - 1.8e-30 105.3 0.0 4e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48181.1 - 2.2e-20 73.1 0.0 3.7e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 PIK48181.1 - 0.0023 17.7 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase-like DUF5638 PF18688.1 PIK48182.1 - 2.4 8.5 13.5 20 5.5 1.7 3.3 1 1 2 3 3 3 0 Family of unknown function (DUF5638) RVT_1 PF00078.27 PIK48183.1 - 1.7e-60 204.3 0.2 4.1e-53 180.2 0.1 2.0 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) PQ-loop PF04193.14 PIK48183.1 - 0.071 12.9 0.8 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 PQ loop repeat Ribosomal_S10 PF00338.22 PIK48184.1 - 1.2e-20 73.6 0.0 1.7e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF1759 PF03564.15 PIK48185.1 - 0.001 19.0 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Peptidase_S64 PF08192.11 PIK48185.1 - 9.8 4.5 8.7 7 5.0 6.2 1.8 2 0 0 2 2 2 0 Peptidase family S64 Fibrinogen_C PF00147.18 PIK48186.1 - 5.4e-44 150.6 3.4 5.8e-44 150.5 3.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK48186.1 - 0.033 13.5 0.1 0.035 13.4 0.1 1.1 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain PPO1_KFDV PF12143.8 PIK48186.1 - 0.099 12.7 0.0 0.19 11.8 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF_B2219) eIF3_N PF09440.10 PIK48187.1 - 4e-24 85.6 1.3 1.2e-23 84.0 1.3 1.9 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 PIK48187.1 - 7.2e-12 45.7 0.0 2.5e-11 44.0 0.0 2.0 1 0 0 1 1 1 1 PCI domain TPR_3 PF07720.12 PIK48187.1 - 0.0018 18.2 1.2 0.0051 16.8 1.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat ApoLp-III PF07464.11 PIK48187.1 - 0.28 11.3 6.3 0.36 10.9 0.3 3.0 4 0 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Palm_thioest PF02089.15 PIK48188.1 - 6.7e-77 258.6 0.0 7.9e-77 258.4 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 PIK48188.1 - 0.037 13.3 0.2 4.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 PIK48188.1 - 0.04 13.6 0.0 0.061 13.0 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.22 PIK48189.1 - 2.7e-31 108.9 0.1 3.4e-31 108.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 GLTP PF08718.11 PIK48189.1 - 0.081 13.2 0.5 0.12 12.7 0.5 1.5 1 1 0 1 1 1 0 Glycolipid transfer protein (GLTP) AA_permease_2 PF13520.6 PIK48190.1 - 4.4e-24 85.1 21.1 6.9e-12 44.9 14.2 2.3 2 1 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 PIK48190.1 - 3.3e-09 35.9 11.6 5.5e-09 35.1 11.6 1.4 1 0 0 1 1 1 1 Amino acid permease MARVEL PF01284.23 PIK48190.1 - 0.0009 19.3 3.7 0.0038 17.3 1.8 2.4 2 1 0 2 2 2 1 Membrane-associating domain DUF389 PF04087.14 PIK48190.1 - 0.02 15.0 4.9 0.025 14.6 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF389) WSC PF01822.19 PIK48192.1 - 4e-07 30.1 2.8 1.2e-06 28.6 2.8 2.0 1 0 0 1 1 1 1 WSC domain Sushi PF00084.20 PIK48192.1 - 0.00074 20.1 0.4 0.0024 18.4 0.1 2.1 1 1 0 1 1 1 1 Sushi repeat (SCR repeat) 7tm_1 PF00001.21 PIK48193.1 - 1.3e-13 50.9 14.1 1.8e-13 50.4 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) OAD_gamma PF04277.13 PIK48193.1 - 0.15 12.7 0.2 0.15 12.7 0.2 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain XendoU PF09412.10 PIK48194.1 - 7.8e-78 261.3 4.8 1.1e-77 260.9 4.8 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK48194.1 - 9.1e-12 45.2 36.4 7.1e-06 26.3 12.8 2.5 2 0 0 2 2 2 2 Somatomedin B domain EndoU_bacteria PF14436.6 PIK48194.1 - 0.012 16.0 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial EndoU nuclease GREB1 PF15782.5 PIK48195.1 - 8.3e-88 295.2 2.4 2.4e-70 237.3 0.4 2.0 2 0 0 2 2 2 2 Gene regulated by oestrogen in breast cancer GREB1 PF15782.5 PIK48196.1 - 3.6e-82 276.5 2.9 7.4e-43 146.1 0.4 2.0 1 1 1 2 2 2 2 Gene regulated by oestrogen in breast cancer IFT43 PF15305.6 PIK48196.1 - 0.055 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Intraflagellar transport protein 43 RVT_1 PF00078.27 PIK48197.1 - 7.8e-42 143.3 0.2 1.9e-41 142.0 0.2 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK48197.1 - 0.006 16.5 0.3 0.22 11.4 0.0 2.3 2 0 0 2 2 2 1 Med18 protein Trep_Strep PF09605.10 PIK48197.1 - 0.78 9.7 3.2 0.35 10.8 0.7 1.7 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) GREB1 PF15782.5 PIK48198.1 - 2.2e-103 346.8 9.5 2.7e-43 147.6 0.2 3.0 1 1 1 3 3 3 3 Gene regulated by oestrogen in breast cancer GREB1 PF15782.5 PIK48199.1 - 3.4e-112 376.1 0.6 1.9e-67 227.7 0.2 2.0 1 1 1 2 2 2 2 Gene regulated by oestrogen in breast cancer Abhydrolase_1 PF00561.20 PIK48200.1 - 3.8e-29 102.1 0.0 6.8e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 PIK48200.1 - 1.3e-05 25.0 0.0 2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 PIK48200.1 - 5.6e-05 22.5 0.0 0.075 12.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 BAAT_C PF08840.11 PIK48200.1 - 0.002 18.1 0.0 0.7 9.8 0.0 2.5 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal EF-hand_1 PF00036.32 PIK48201.1 - 4.2e-25 85.4 7.2 2.7e-08 32.8 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 PIK48201.1 - 1.1e-24 86.7 1.2 3e-16 59.6 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK48201.1 - 2.7e-22 76.7 0.9 3.6e-06 26.5 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 PIK48201.1 - 5.4e-21 73.1 6.2 6e-06 25.5 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK48201.1 - 9.3e-15 54.2 6.8 1.4e-06 28.1 0.8 3.6 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK48201.1 - 3.2e-06 27.4 0.1 0.0079 16.5 0.1 3.1 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK48201.1 - 9.2e-05 22.3 1.7 0.54 10.2 0.1 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 PIK48201.1 - 0.012 15.8 1.8 0.76 10.0 0.8 2.7 1 1 2 3 3 3 0 Dockerin type I domain EF-hand_10 PF14788.6 PIK48201.1 - 0.16 11.8 0.3 23 4.9 0.0 2.6 2 0 0 2 2 2 0 EF hand Ezh2_MCSS PF18600.1 PIK48201.1 - 0.3 10.7 1.2 0.51 10.0 0.6 1.7 2 0 0 2 2 2 0 MCSS domain Hist_deacetyl PF00850.19 PIK48202.1 - 2.1e-50 172.0 0.2 2.3e-50 171.8 0.2 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Hist_deacetyl PF00850.19 PIK48203.1 - 1.3e-25 90.6 0.0 2.4e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain DUF616 PF04765.13 PIK48204.1 - 0.081 12.2 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF616) Ank_2 PF12796.7 PIK48205.1 - 1.2e-13 51.5 0.0 1.3e-05 25.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK48205.1 - 7.5e-13 47.4 0.0 5.2e-06 26.4 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 PIK48205.1 - 5.1e-12 46.1 0.0 8.3e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK48205.1 - 5.5e-12 45.6 0.1 1.8e-05 25.0 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK48205.1 - 1.1e-09 38.4 0.1 5.4e-06 26.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_10 PF17902.1 PIK48205.1 - 0.046 13.8 0.1 1.6 8.8 0.0 2.2 2 0 0 2 2 2 0 SH3 domain Sushi PF00084.20 PIK48206.1 - 6.2e-12 45.9 3.0 5.1e-07 30.2 0.5 3.2 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) WSC PF01822.19 PIK48206.1 - 0.0086 16.2 6.3 0.018 15.2 6.3 1.6 1 0 0 1 1 1 1 WSC domain Stevor PF17410.2 PIK48206.1 - 0.013 15.1 0.1 0.018 14.6 0.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 PIK48206.1 - 0.057 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Cas9_Topo PF17894.1 PIK48206.1 - 0.16 12.0 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 SRCR PF00530.18 PIK48207.1 - 7.5e-29 100.2 2.9 9e-29 99.9 2.9 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48207.1 - 1e-05 26.0 0.5 1.4e-05 25.5 0.5 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain C2 PF00168.30 PIK48208.1 - 1.8e-22 79.6 0.0 3e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain NT-C2 PF10358.9 PIK48208.1 - 0.094 12.4 0.0 2.8 7.6 0.0 2.2 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins Neurexophilin PF06312.12 PIK48212.1 - 1.2e-05 24.9 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Neurexophilin PHD_4 PF16866.5 PIK48213.1 - 0.29 11.3 3.9 6.7 6.9 0.1 3.0 3 0 0 3 3 3 0 PHD-finger RT_RNaseH PF17917.1 PIK48215.1 - 1.6e-34 118.3 0.0 2.7e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK48215.1 - 3.6e-33 113.6 0.0 7.8e-33 112.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48215.1 - 4.7e-08 32.8 0.0 1e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3896 PF13035.6 PIK48215.1 - 0.049 13.8 0.1 0.17 12.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) Lectin_C PF00059.21 PIK48216.1 - 1e-06 29.4 0.9 1.7e-05 25.5 0.9 2.1 1 1 0 1 1 1 1 Lectin C-type domain Olduvai PF06758.13 PIK48216.1 - 0.073 13.3 4.6 3.5 7.9 0.1 2.5 3 0 0 3 3 3 0 Olduvai domain 7tm_1 PF00001.21 PIK48217.1 - 7e-43 146.8 16.7 9.6e-43 146.4 16.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK48217.1 - 8.8e-11 41.7 18.4 1.2e-10 41.3 18.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK48217.1 - 8.3e-10 38.7 24.2 9.2e-10 38.6 21.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Srg PF02118.21 PIK48217.1 - 3.8 7.1 29.2 0.026 14.2 13.6 3.2 3 1 0 3 3 3 0 Srg family chemoreceptor zf-C3HC4 PF00097.25 PIK48219.1 - 4.4e-08 32.8 7.3 4.4e-08 32.8 7.3 3.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK48219.1 - 5e-07 29.6 4.4 5e-07 29.6 4.4 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK48219.1 - 1.3e-05 25.0 7.4 1.3e-05 25.0 7.4 3.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK48219.1 - 1.4e-05 25.1 7.8 1.4e-05 25.1 7.8 3.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK48219.1 - 1.5e-05 24.8 4.8 1.5e-05 24.8 4.8 3.6 3 0 0 3 3 2 2 zinc-RING finger domain zf-RING_2 PF13639.6 PIK48219.1 - 8.8e-05 22.8 5.5 8.8e-05 22.8 5.5 4.1 4 0 0 4 4 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK48219.1 - 0.0002 21.1 5.1 0.0002 21.1 5.1 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK48219.1 - 0.00025 21.1 4.4 0.00025 21.1 4.4 4.8 5 0 0 5 5 5 2 B-box zinc finger DUF5018 PF16410.5 PIK48219.1 - 0.059 12.1 0.0 0.15 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5018) TPR_22 PF18833.1 PIK48219.1 - 0.11 12.6 1.7 0.27 11.4 1.7 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat NHL PF01436.21 PIK48219.1 - 2.6 8.2 7.7 34 4.7 0.0 4.5 5 0 0 5 5 5 0 NHL repeat zf-RING_UBOX PF13445.6 PIK48220.1 - 2.2e-09 37.2 6.0 2.2e-09 37.2 6.0 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK48220.1 - 2.2e-09 37.0 9.0 2.2e-09 37.0 9.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK48220.1 - 6e-07 29.2 9.1 6e-07 29.2 9.1 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48220.1 - 3.9e-06 27.1 7.7 3.9e-06 27.1 7.7 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK48220.1 - 5.4e-06 26.2 33.7 5.5e-06 26.1 9.9 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK48220.1 - 6.8e-06 26.1 9.5 6.8e-06 26.1 9.5 3.5 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK48220.1 - 7.9e-05 22.5 7.3 7.9e-05 22.5 7.3 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK48220.1 - 0.004 17.3 7.6 0.004 17.3 7.6 4.3 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK48220.1 - 0.018 14.9 10.9 0.018 14.9 10.9 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-MYST PF17772.1 PIK48220.1 - 0.3 10.7 8.4 0.37 10.4 0.6 2.8 2 1 0 2 2 2 0 MYST family zinc finger domain zf-C3HC4 PF00097.25 PIK48221.1 - 5.3e-09 35.8 8.8 5.3e-09 35.8 8.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK48221.1 - 4.3e-08 33.1 10.6 4.3e-08 33.1 10.6 3.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK48221.1 - 2.5e-07 30.4 9.5 2.5e-07 30.4 9.5 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48221.1 - 1.6e-06 28.3 8.1 1.6e-06 28.3 8.1 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK48221.1 - 5.6e-06 26.1 10.2 5.6e-06 26.1 10.2 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK48221.1 - 1.2e-05 25.3 9.9 1.2e-05 25.3 9.9 3.6 3 1 1 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK48221.1 - 2.6e-05 24.1 8.0 2.6e-05 24.1 8.0 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK48221.1 - 0.0029 17.7 7.5 0.0029 17.7 7.5 4.0 5 0 0 5 5 5 2 B-box zinc finger zf-RING_11 PF17123.5 PIK48221.1 - 0.0076 16.0 5.9 0.022 14.5 0.4 3.4 2 1 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 PIK48221.1 - 0.0077 16.1 10.9 0.0077 16.1 10.9 3.2 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.6 PIK48221.1 - 0.53 10.8 0.1 0.53 10.8 0.1 5.8 5 1 1 6 6 5 0 Zinc-finger double domain LRAT PF04970.13 PIK48222.1 - 2.9e-11 43.8 0.5 2.6e-09 37.5 0.5 2.5 1 1 0 1 1 1 1 Lecithin retinol acyltransferase MFS_1 PF07690.16 PIK48223.1 - 2.3e-29 102.4 15.7 2.6e-29 102.3 15.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily IncE PF17627.2 PIK48223.1 - 0.13 12.3 0.9 0.29 11.1 0.9 1.6 1 0 0 1 1 1 0 Inclusion membrane protein E Retrotrans_gag PF03732.17 PIK48224.1 - 0.00094 19.4 0.5 0.0021 18.3 0.5 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 PIK48224.1 - 0.0014 18.6 2.6 0.0014 18.6 2.6 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK48224.1 - 0.014 15.1 5.9 0.014 15.1 5.9 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger EndIII_4Fe-2S PF10576.9 PIK48224.1 - 0.071 13.5 0.1 0.071 13.5 0.1 1.8 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III zf-CCHC_3 PF13917.6 PIK48224.1 - 0.44 10.6 5.6 0.085 12.8 1.2 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK48224.1 - 0.52 10.1 2.6 0.3 10.9 0.4 1.8 1 1 1 2 2 2 0 Zinc knuckle SWIM PF04434.17 PIK48225.1 - 0.0068 16.1 0.3 0.025 14.2 0.3 1.9 2 0 0 2 2 2 1 SWIM zinc finger Fibrinogen_C PF00147.18 PIK48226.1 - 1.5e-30 106.7 1.6 1.7e-30 106.5 1.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF1293 PF06950.11 PIK48226.1 - 0.14 12.3 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1293) RVT_1 PF00078.27 PIK48227.1 - 3.3e-11 43.1 0.0 5.8e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MLVIN_C PF18697.1 PIK48227.1 - 0.072 13.2 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Integrase_H2C2 PF17921.1 PIK48228.1 - 1.8e-19 69.6 1.1 3.9e-19 68.5 1.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK48228.1 - 4.6e-19 68.8 0.0 1.9e-18 66.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain SCAN PF02023.17 PIK48228.1 - 1.7e-15 56.6 0.1 3.7e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2 PF09337.10 PIK48228.1 - 5.6e-05 23.3 0.2 0.00014 22.0 0.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK48228.1 - 0.00071 19.3 0.0 0.0028 17.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.6 PIK48228.1 - 0.15 12.7 0.0 0.54 10.9 0.0 1.9 1 0 0 1 1 1 0 Aspartyl protease AhpC-TSA_2 PF13911.6 PIK48229.1 - 1.9e-16 60.2 0.0 2.6e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 PIK48229.1 - 6.7e-09 35.7 0.0 9.3e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK48229.1 - 0.097 12.4 0.0 0.44 10.3 0.0 1.8 2 0 0 2 2 2 0 Redoxin SPRY PF00622.28 PIK48230.1 - 2.1e-14 53.6 0.0 2.9e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 SPRY domain DUF4954 PF16314.5 PIK48232.1 - 8.9e-08 30.7 15.7 1.1e-05 23.9 5.9 1.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) Hexapep PF00132.24 PIK48232.1 - 2e-07 30.4 17.8 0.00047 19.8 7.7 3.9 2 1 3 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 PIK48232.1 - 5.8e-05 22.2 1.4 6.9e-05 22.0 1.4 1.2 1 0 0 1 1 1 1 L-fucokinase Urease_alpha PF00449.20 PIK48232.1 - 0.069 13.5 0.8 0.1 12.9 0.8 1.3 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain TGFb_propeptide PF00688.18 PIK48233.1 - 1.5e-14 54.3 0.0 2.4e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 PIK48233.1 - 3.3e-12 47.3 0.1 8.2e-12 46.0 0.1 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain Nha1_C PF08619.10 PIK48233.1 - 0.02 14.1 2.1 0.028 13.6 2.1 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus zf-C2H2 PF00096.26 PIK48234.1 - 1.6e-14 53.4 26.6 8.3e-05 22.8 5.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK48234.1 - 3.8e-11 42.9 11.7 1.7e-07 31.3 2.3 4.5 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK48234.1 - 8.9e-08 32.3 23.6 0.0037 18.0 4.3 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48234.1 - 0.095 13.0 5.7 3.9 7.9 0.8 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 PIK48234.1 - 0.097 13.3 5.4 3.4 8.4 0.8 3.2 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 PIK48234.1 - 0.69 10.3 7.5 0.65 10.3 5.5 2.0 2 1 0 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.7 PIK48234.1 - 2.4 8.7 8.6 11 6.6 1.2 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK48234.1 - 6.4 7.2 10.3 2.5 8.5 0.8 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Ribos_L4_asso_C PF14374.6 PIK48236.1 - 0.026 14.6 0.2 0.069 13.2 0.2 1.7 1 0 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain bHLH-MYC_N PF14215.6 PIK48236.1 - 0.089 13.1 5.3 0.16 12.2 5.3 1.4 1 1 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal Ldt_C PF17969.1 PIK48236.1 - 0.17 12.7 2.4 0.2 12.4 0.7 2.0 1 1 1 2 2 2 0 L,D-transpeptidase C-terminal domain SOCS PF12610.8 PIK48236.1 - 4 7.9 8.1 0.51 10.8 3.1 2.1 2 0 0 2 2 2 0 Suppressor of cytokine signalling RVT_1 PF00078.27 PIK48237.1 - 2.9e-12 46.6 0.0 6e-12 45.6 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK48238.1 - 2.9e-12 46.6 0.0 6e-12 45.6 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK48239.1 - 6.9e-23 81.1 0.0 1.5e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK48239.1 - 8e-07 28.8 0.2 3e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK48240.1 - 2.6e-20 72.9 0.0 4.1e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK48240.1 - 6.2e-07 29.2 1.6 1.3e-06 28.2 1.6 1.6 1 0 0 1 1 1 1 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK48240.1 - 0.00027 20.9 0.1 0.00064 19.7 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48240.1 - 0.00047 20.4 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC_3 PF13917.6 PIK48240.1 - 0.0055 16.6 0.1 0.015 15.2 0.1 1.8 1 0 0 1 1 1 1 Zinc knuckle KASH_CCD PF14662.6 PIK48240.1 - 0.027 14.3 2.7 0.56 10.0 0.1 2.9 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH zf-CCHC_2 PF13696.6 PIK48240.1 - 0.094 12.6 1.8 0.22 11.4 1.8 1.6 1 0 0 1 1 1 0 Zinc knuckle ETF_QO PF05187.13 PIK48242.1 - 4e-41 139.4 0.8 7.3e-41 138.5 0.8 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 PIK48242.1 - 7.1e-10 39.0 0.9 5e-06 26.3 0.4 2.5 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK48242.1 - 1.6e-07 30.8 0.3 7.1e-05 22.1 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 PIK48242.1 - 2.3e-06 27.0 0.0 3.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK48242.1 - 5.3e-06 26.6 0.1 4.5e-05 23.6 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK48242.1 - 6.3e-06 25.6 0.0 1.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 PIK48242.1 - 4e-05 24.1 0.1 0.31 11.6 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK48242.1 - 9.4e-05 22.5 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 PIK48242.1 - 0.00023 20.3 0.1 0.00034 19.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 PIK48242.1 - 0.00026 20.4 0.1 0.00044 19.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 PIK48242.1 - 0.00028 19.7 0.0 0.00041 19.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 PIK48242.1 - 0.0018 17.6 0.1 0.0028 17.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK48242.1 - 0.0074 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 PIK48242.1 - 0.0075 15.2 0.6 0.096 11.5 0.1 2.5 3 0 0 3 3 3 1 Tryptophan halogenase Fer4_7 PF12838.7 PIK48242.1 - 0.041 14.5 1.1 0.11 13.2 1.1 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain AlaDh_PNT_C PF01262.21 PIK48242.1 - 0.088 12.1 0.0 0.41 9.9 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 PIK48242.1 - 0.16 11.2 0.7 0.24 10.7 0.2 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase dsrm PF00035.26 PIK48243.1 - 1.5e-10 41.7 0.0 2.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK48243.1 - 0.0072 16.6 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Helicase_C PF00271.31 PIK48244.1 - 7.9e-15 55.2 0.0 2.4e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 PIK48244.1 - 2.8e-14 53.3 0.9 5.7e-14 52.3 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK48244.1 - 2.6e-12 46.9 0.0 5.8e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Peptidase_M24 PF00557.24 PIK48245.1 - 7.4e-56 189.1 0.0 8.6e-56 188.9 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 PIK48246.1 - 4e-38 129.9 0.0 5.4e-38 129.5 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Romo1 PF10247.9 PIK48246.1 - 0.13 12.7 0.5 19 5.7 0.0 2.3 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Voltage_CLC PF00654.20 PIK48248.1 - 8.5e-101 337.7 20.7 1.7e-99 333.4 21.2 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 PIK48248.1 - 4.7e-11 43.0 0.0 0.0001 22.7 0.0 2.5 2 0 0 2 2 2 2 CBS domain PDZ PF00595.24 PIK48249.1 - 2.8e-06 27.6 0.0 1.4e-05 25.4 0.0 2.0 1 1 0 1 1 1 1 PDZ domain DUF4757 PF15949.5 PIK48249.1 - 4.1e-06 27.4 14.1 4.1e-06 27.4 14.1 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4757) PDZ_6 PF17820.1 PIK48249.1 - 0.0003 20.6 0.0 0.00062 19.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PMP22_Claudin PF00822.20 PIK48252.1 - 0.0082 16.0 0.9 0.012 15.5 0.9 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family GATase_5 PF13507.6 PIK48253.1 - 8.6e-50 169.2 0.0 1.6e-49 168.4 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 PIK48253.1 - 1.6e-39 135.5 2.1 5.2e-22 78.7 0.2 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 PIK48253.1 - 3e-17 62.7 0.0 5.9e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 PIK48253.1 - 1.1e-11 45.1 0.0 4.5e-11 43.1 0.0 2.1 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain Ribosomal_L30 PF00327.20 PIK48256.1 - 1.6e-06 27.9 0.1 3.1e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e BEN PF10523.9 PIK48257.1 - 6.1e-12 45.6 0.2 1.8e-11 44.1 0.2 1.9 1 0 0 1 1 1 1 BEN domain HTH_32 PF13565.6 PIK48257.1 - 1.9e-07 31.6 1.9 1.2e-06 29.1 0.1 2.8 2 1 1 3 3 3 1 Homeodomain-like domain PAX PF00292.18 PIK48257.1 - 0.018 15.0 0.2 0.05 13.5 0.2 1.8 1 0 0 1 1 1 0 'Paired box' domain DbpA PF03880.15 PIK48257.1 - 0.13 12.3 0.3 0.29 11.2 0.3 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain Pan3_PK PF18101.1 PIK48258.1 - 1.8e-60 202.9 0.0 2.9e-60 202.2 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 PIK48258.1 - 3.3e-05 23.4 0.0 0.00013 21.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain WES_acyltransf PF03007.16 PIK48258.1 - 0.069 12.9 0.6 0.12 12.1 0.6 1.3 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain RabGAP-TBC PF00566.18 PIK48259.1 - 4e-49 167.2 4.8 5.6e-49 166.7 4.8 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HTH_Tnp_Mu_2 PF09039.11 PIK48261.1 - 0.099 12.7 0.0 0.25 11.5 0.0 1.6 1 1 0 1 1 1 0 Mu DNA binding, I gamma subdomain SNase PF00565.17 PIK48262.1 - 2.2e-63 211.5 0.0 7.8e-16 58.5 0.0 5.2 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 PIK48262.1 - 3.2e-24 85.3 0.0 6e-24 84.4 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 PIK48262.1 - 0.0062 17.0 0.1 0.042 14.3 0.1 2.4 1 0 0 1 1 1 1 Agenet domain SMN PF06003.12 PIK48262.1 - 0.1 11.8 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) RT_RNaseH_2 PF17919.1 PIK48264.1 - 2.2e-29 101.4 0.2 6.3e-29 100.0 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48264.1 - 1.1e-28 100.2 0.0 3.6e-28 98.6 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK48264.1 - 2.3e-27 95.3 0.0 4.8e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK48264.1 - 4.8e-18 65.0 2.2 1.1e-17 63.9 2.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK48264.1 - 5.3e-06 26.5 3.7 3.1e-05 24.1 1.4 3.1 3 0 0 3 3 3 1 H2C2 zinc finger RVP PF00077.20 PIK48264.1 - 0.021 15.1 0.0 0.093 13.1 0.0 2.1 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-H3C2 PF16721.5 PIK48264.1 - 0.022 15.1 0.0 0.079 13.3 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding gag-asp_proteas PF13975.6 PIK48264.1 - 0.095 13.3 0.0 0.27 11.8 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease NRBF2 PF08961.10 PIK48265.1 - 0.01 15.5 0.5 0.01 15.5 0.5 2.3 2 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator ZapB PF06005.12 PIK48265.1 - 0.067 13.6 0.8 0.067 13.6 0.8 2.5 2 0 0 2 2 2 0 Cell division protein ZapB CtIP_N PF10482.9 PIK48265.1 - 0.071 13.2 3.2 0.21 11.7 1.9 2.3 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain NYD-SP28_assoc PF14775.6 PIK48265.1 - 0.22 11.6 0.3 0.22 11.6 0.3 1.9 2 0 0 2 2 2 0 Sperm tail C-terminal domain PSI_PsaF PF02507.15 PIK48265.1 - 0.27 11.1 0.7 0.54 10.1 0.7 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Elf4 PF07011.11 PIK48265.1 - 0.49 10.3 2.7 1.1 9.3 2.7 1.5 1 0 0 1 1 1 0 Early Flowering 4 domain PikAIV_N PF18605.1 PIK48265.1 - 1.3 8.6 5.5 0.78 9.4 2.6 2.1 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain DivIC PF04977.15 PIK48265.1 - 1.7 8.5 6.0 0.86 9.4 1.5 2.5 1 1 1 2 2 2 0 Septum formation initiator PA26 PF04636.13 PIK48266.1 - 1e-99 334.5 3.2 1.2e-99 334.2 3.2 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Y_phosphatase PF00102.27 PIK48267.1 - 5.1e-70 235.7 0.4 2.6e-34 118.8 0.3 3.1 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK48267.1 - 0.004 17.0 0.7 0.0089 15.8 0.1 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CUB PF00431.20 PIK48268.1 - 2.2e-08 34.4 0.0 2.7e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 CUB domain Y_phosphatase PF00102.27 PIK48270.1 - 1.7e-64 217.6 1.0 4.5e-30 105.0 0.0 3.5 2 1 1 3 3 3 3 Protein-tyrosine phosphatase fn3 PF00041.21 PIK48270.1 - 8.6e-13 48.4 6.0 4.7e-06 26.9 0.6 3.0 2 0 0 2 2 2 2 Fibronectin type III domain DUF4448 PF14610.6 PIK48270.1 - 0.00041 20.2 0.3 0.0015 18.3 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 PIK48270.1 - 0.00089 19.2 0.5 0.0026 17.7 0.5 1.7 1 0 0 1 1 1 1 TMEM154 protein family Pur_ac_phosph_N PF16656.5 PIK48270.1 - 0.0012 19.3 13.6 0.0066 17.0 4.0 3.3 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Glycophorin_A PF01102.18 PIK48270.1 - 0.0057 16.9 0.2 0.03 14.6 0.0 2.4 2 0 0 2 2 2 1 Glycophorin A DUF2207 PF09972.9 PIK48270.1 - 0.032 13.0 0.0 0.084 11.6 0.0 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) His_biosynth PF00977.21 PIK48270.1 - 0.037 13.5 0.0 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein Herpes_gE PF02480.16 PIK48270.1 - 0.055 12.2 0.4 0.16 10.7 0.0 1.8 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E PRD PF00874.20 PIK48270.1 - 0.11 12.8 0.5 0.47 10.8 0.1 2.2 2 0 0 2 2 2 0 PRD domain SKG6 PF08693.10 PIK48270.1 - 9.6 5.7 9.3 23 4.5 9.3 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain 60KD_IMP PF02096.20 PIK48272.1 - 1.1e-16 61.1 0.1 1.1e-15 57.9 0.1 2.1 1 1 0 1 1 1 1 60Kd inner membrane protein NTF2 PF02136.20 PIK48274.1 - 7.4e-29 100.8 0.3 1.1e-28 100.2 0.3 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 PIK48274.1 - 1.6e-12 47.1 0.2 2.8e-12 46.3 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK48274.1 - 0.00015 21.8 0.0 0.00038 20.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif DNA_pol_phi PF04931.13 PIK48274.1 - 0.94 7.5 3.9 1.2 7.1 3.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pkinase PF00069.25 PIK48275.1 - 8.1e-64 215.5 0.0 8.1e-64 215.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48275.1 - 8e-32 110.5 0.1 2.3e-30 105.7 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK48275.1 - 0.00011 21.3 0.1 0.00011 21.3 0.1 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Sigma54_AID PF00309.20 PIK48275.1 - 0.055 13.3 0.1 0.055 13.3 0.1 2.8 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) APH PF01636.23 PIK48275.1 - 0.12 12.3 4.2 0.41 10.5 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4407 PF14362.6 PIK48275.1 - 2.2 7.5 6.8 3.7 6.8 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 PIK48275.1 - 3.9 7.4 22.5 1.4 8.9 8.5 2.3 2 0 0 2 2 2 0 Protein Family FAM60A RR_TM4-6 PF06459.12 PIK48275.1 - 5.4 6.8 24.2 0.14 12.0 10.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SH2 PF00017.24 PIK48276.1 - 5.4e-14 52.0 0.1 6.8e-14 51.7 0.1 1.1 1 0 0 1 1 1 1 SH2 domain I-set PF07679.16 PIK48278.1 - 4.9e-20 71.4 0.3 3.4e-11 43.1 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK48278.1 - 6.7e-17 61.9 0.0 2.8e-06 27.8 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK48278.1 - 1.2e-07 31.9 0.3 0.012 16.0 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin domain Kazal_2 PF07648.15 PIK48278.1 - 3.9e-07 30.1 5.9 4.3e-07 29.9 3.1 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain ig PF00047.25 PIK48278.1 - 1.1e-06 28.6 0.0 0.00037 20.6 0.0 2.9 2 1 0 2 2 2 1 Immunoglobulin domain Kazal_1 PF00050.21 PIK48278.1 - 5.9e-06 26.2 6.1 1.9e-05 24.6 6.1 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 PIK48278.1 - 2.7e-05 23.7 3.2 0.0022 17.8 1.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 PIK48278.1 - 0.00016 21.0 2.5 0.036 13.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 PIK48278.1 - 0.00036 19.9 4.0 0.006 16.0 0.9 2.5 2 0 0 2 2 2 1 EF hand V-set PF07686.17 PIK48278.1 - 0.00091 19.4 1.7 5.5 7.2 0.1 4.4 2 2 0 2 2 2 1 Immunoglobulin V-set domain SPARC_Ca_bdg PF10591.9 PIK48278.1 - 0.0011 19.3 0.2 0.0024 18.2 0.2 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 PIK48278.1 - 0.0081 16.6 2.6 0.023 15.1 2.6 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK48278.1 - 0.02 14.7 2.5 0.17 11.8 0.5 2.5 1 1 1 2 2 2 0 EF-hand domain pair Tnp_P_element_C PF12596.8 PIK48278.1 - 0.064 13.8 0.1 0.21 12.1 0.0 1.9 1 1 0 1 1 1 0 87kDa Transposase FOLN PF09289.10 PIK48278.1 - 0.081 13.1 2.3 0.089 13.0 0.4 2.2 2 0 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain La PF05383.17 PIK48279.1 - 7.2e-21 74.0 0.1 1.3e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 PIK48279.1 - 3.1e-12 46.1 0.0 6.6e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 PIK48280.1 - 4.9e-77 258.9 0.0 5.6e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48280.1 - 3.4e-36 124.9 0.0 4.2e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK48280.1 - 4.1e-05 22.7 0.0 0.00025 20.1 0.1 2.2 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 PIK48280.1 - 0.00082 18.8 0.0 0.0072 15.7 0.0 2.0 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 PIK48280.1 - 0.0012 18.5 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK48280.1 - 0.0037 17.2 0.0 0.013 15.4 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Vps39_2 PF10367.9 PIK48280.1 - 0.2 12.1 0.1 0.32 11.5 0.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 TolA_bind_tri PF16331.5 PIK48282.1 - 0.038 14.1 1.1 0.038 14.1 1.1 4.6 3 1 2 5 5 5 0 TolA binding protein trimerisation Thioredoxin_2 PF13098.6 PIK48282.1 - 0.16 12.4 4.1 0.18 12.3 1.2 2.6 2 1 0 2 2 2 0 Thioredoxin-like domain DUF720 PF05302.11 PIK48282.1 - 2.8 7.8 7.9 0.43 10.4 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF720) GSHPx PF00255.19 PIK48283.1 - 5.6e-27 93.5 0.0 7.8e-27 93.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase ORC4_C PF14629.6 PIK48284.1 - 0.023 14.1 0.3 0.037 13.4 0.3 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus EIAV_GP90 PF00971.18 PIK48284.1 - 0.13 10.9 0.2 0.18 10.4 0.2 1.2 1 0 0 1 1 1 0 EIAV coat protein, gp90 U1snRNP70_N PF12220.8 PIK48284.1 - 3.3 8.4 8.2 11 6.7 0.0 2.5 1 1 1 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3141 PF11339.8 PIK48285.1 - 0.092 11.2 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Guanylate_cyc PF00211.20 PIK48286.1 - 9.2e-55 185.1 0.0 1e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain SNF PF00209.18 PIK48287.1 - 3e-28 98.8 16.8 3.9e-28 98.4 16.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family RVT_1 PF00078.27 PIK48288.1 - 2.2e-19 69.9 0.1 5.1e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK48288.1 - 0.0036 17.3 1.5 0.0036 17.3 1.5 2.8 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 PIK48288.1 - 0.035 14.5 0.7 0.035 14.5 0.7 3.0 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zf-CCCH_7 PF18586.1 PIK48288.1 - 0.28 11.5 5.1 0.29 11.5 2.8 2.3 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 zf-CCHC_5 PF14787.6 PIK48288.1 - 1.2 8.9 13.7 0.14 11.9 4.0 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK48288.1 - 5 7.2 8.5 2.4 8.2 2.7 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK48288.1 - 5.6 6.9 10.3 0.084 12.7 2.0 2.3 2 0 0 2 2 2 0 Zinc knuckle p450 PF00067.22 PIK48289.1 - 2.5e-124 415.5 0.0 2.8e-124 415.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-H2C2_2 PF13465.6 PIK48291.1 - 2.3e-44 147.9 78.7 1.3e-08 34.8 1.9 10.6 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48291.1 - 3.7e-29 99.5 81.0 5.1e-05 23.5 1.9 9.6 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48291.1 - 6.5e-28 95.0 76.7 0.00029 21.4 0.8 9.9 9 0 0 9 9 9 9 C2H2-type zinc finger HipN PF18253.1 PIK48291.1 - 2e-14 53.0 0.1 3.5e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain zf-C2H2_jaz PF12171.8 PIK48291.1 - 5.1e-11 42.5 46.3 0.032 14.5 0.6 8.7 8 0 0 8 8 8 7 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 PIK48291.1 - 2.9e-08 34.0 52.1 1.1 9.8 0.2 9.5 1 1 7 8 8 8 7 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 PIK48291.1 - 0.00037 20.2 9.1 0.0021 17.8 2.1 8.1 9 0 0 9 9 7 3 zinc-finger C2H2-type PyrI_C PF02748.15 PIK48291.1 - 0.001 18.9 44.7 1.4 8.8 0.1 9.1 8 1 1 9 9 9 5 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 PIK48291.1 - 0.007 16.3 71.1 0.017 15.2 1.4 9.6 9 0 0 9 9 9 5 C2H2-type zinc finger DUF3268 PF11672.8 PIK48291.1 - 0.057 13.7 32.2 0.19 12.1 2.0 4.7 4 1 0 4 4 4 0 zinc-finger-containing domain FerB PF08150.12 PIK48291.1 - 0.46 11.1 3.1 54 4.5 0.0 4.3 2 1 2 4 4 4 0 FerB (NUC096) domain zf-C2H2_2 PF12756.7 PIK48291.1 - 2.5 8.5 54.3 0.12 12.8 0.9 8.6 2 1 6 8 8 7 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 PIK48291.1 - 9.3 6.4 63.7 0.096 12.7 1.5 9.8 3 2 7 10 10 10 0 BED zinc finger 4HBT PF03061.22 PIK48292.1 - 9.1e-06 25.9 0.1 0.031 14.6 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily BH4 PF02180.17 PIK48293.1 - 0.0064 16.3 0.3 20 5.1 0.0 3.5 3 0 0 3 3 3 2 Bcl-2 homology region 4 Alpha_TIF PF02232.15 PIK48293.1 - 0.052 12.7 2.6 3.7 6.6 0.1 2.6 2 1 1 3 3 3 0 Alpha trans-inducing protein (Alpha-TIF) Terminase_6C PF17289.2 PIK48293.1 - 0.14 12.2 0.0 15 5.7 0.0 2.7 1 1 2 3 3 3 0 Terminase RNaseH-like domain Na_H_Exchanger PF00999.21 PIK48294.1 - 0.041 12.7 17.2 17 4.0 17.0 2.4 1 1 0 1 1 1 0 Sodium/hydrogen exchanger family TMEM169 PF15052.6 PIK48294.1 - 0.23 11.6 1.9 3.3 7.8 0.2 2.3 2 0 0 2 2 2 0 TMEM169 protein family MRP-S28 PF10213.9 PIK48295.1 - 1.7e-13 51.1 0.0 3.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein ERO1 PF04137.15 PIK48295.1 - 0.04 13.1 1.0 0.061 12.5 1.0 1.3 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) 3HBOH PF10605.9 PIK48295.1 - 0.053 11.7 0.0 0.073 11.3 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) ProRS-C_1 PF09180.11 PIK48295.1 - 0.069 13.4 0.1 0.22 11.7 0.1 1.8 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal 7tm_1 PF00001.21 PIK48296.1 - 4.3e-23 82.0 9.7 5.5e-23 81.6 9.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cadherin PF00028.17 PIK48297.1 - 3.8e-15 56.1 0.2 5.7e-15 55.5 0.2 1.3 1 0 0 1 1 1 1 Cadherin domain Cadherin_3 PF16184.5 PIK48297.1 - 0.00071 19.6 0.2 0.013 15.5 0.1 2.2 2 0 0 2 2 2 1 Cadherin-like Cadherin PF00028.17 PIK48298.1 - 3.9e-99 325.3 10.3 1.5e-19 70.2 0.1 7.0 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 PIK48298.1 - 1.2e-13 50.6 0.0 0.11 12.3 0.0 5.6 6 0 0 6 6 6 5 Cadherin-like Cadherin_3 PF16184.5 PIK48298.1 - 8.4e-09 35.4 10.6 0.087 12.8 0.0 6.1 6 1 0 6 6 6 4 Cadherin-like Cadherin PF00028.17 PIK48299.1 - 7.7e-134 436.5 23.2 3.3e-19 69.1 0.1 13.9 11 2 1 12 12 12 12 Cadherin domain Cadherin_2 PF08266.12 PIK48299.1 - 1.7e-13 50.2 0.0 2.6 7.9 0.0 8.5 9 0 0 9 9 9 5 Cadherin-like PepSY PF03413.19 PIK48299.1 - 9.5e-06 26.1 4.7 17 6.1 0.0 8.3 8 0 0 8 8 8 1 Peptidase propeptide and YPEB domain RET_CLD1 PF17756.1 PIK48299.1 - 1.2e-05 25.6 0.0 0.59 10.4 0.0 5.8 7 0 0 7 7 7 2 RET Cadherin like domain 1 EF-hand_5 PF13202.6 PIK48300.1 - 0.046 13.2 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 PIK48300.1 - 0.052 13.1 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 PIK48300.1 - 0.098 13.1 0.1 0.43 11.1 0.1 2.1 1 1 0 1 1 1 0 EF-hand domain pair RRM_occluded PF16842.5 PIK48300.1 - 0.13 12.2 0.8 0.41 10.5 0.0 2.3 3 0 0 3 3 3 0 Occluded RNA-recognition motif Methuselah_N PF06652.12 PIK48301.1 - 0.065 13.1 0.2 0.6 10.0 0.0 2.4 3 0 0 3 3 3 0 Methuselah N-terminus CD34_antigen PF06365.12 PIK48301.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family RT_RNaseH_2 PF17919.1 PIK48302.1 - 1.1e-20 73.5 0.0 2.6e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48302.1 - 1.6e-08 34.8 0.0 4.5e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48302.1 - 0.0098 15.4 0.1 0.02 14.4 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ApeC PF16977.5 PIK48303.1 - 4.1e-35 121.6 0.0 4.8e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 C-terminal domain of apextrin RT_RNaseH_2 PF17919.1 PIK48304.1 - 1.5e-34 118.0 0.0 2.5e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48304.1 - 2.9e-29 101.5 0.0 4.2e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48304.1 - 0.00014 21.4 0.1 0.00021 20.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CUB PF00431.20 PIK48305.1 - 0.0025 18.1 0.0 0.0038 17.5 0.0 1.3 1 0 0 1 1 1 1 CUB domain CUB PF00431.20 PIK48306.1 - 1.4e-14 54.3 0.0 2.3e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 PIK48306.1 - 9.5e-06 25.7 6.9 0.0027 17.9 2.2 2.4 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF1672 PF07901.11 PIK48306.1 - 0.093 12.0 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) CUB PF00431.20 PIK48307.1 - 4.9e-70 232.9 0.0 5.6e-11 42.8 0.0 8.8 9 0 0 9 9 9 8 CUB domain Trypsin PF00089.26 PIK48307.1 - 5.1e-29 101.7 0.0 8.5e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK48307.1 - 2e-12 47.1 92.0 7.8e-06 26.0 12.3 8.4 8 0 0 8 8 8 6 Low-density lipoprotein receptor domain class A zf-H2C2_2 PF13465.6 PIK48308.1 - 1.1e-46 155.2 44.2 3.9e-10 39.7 1.5 6.4 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48308.1 - 8.5e-25 85.8 50.1 1.9e-06 28.0 1.9 6.8 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48308.1 - 1.5e-15 56.6 49.4 0.0001 22.8 1.3 7.0 8 0 0 8 8 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48308.1 - 6.1e-13 48.7 33.8 0.0049 17.1 0.3 6.2 7 0 0 7 7 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK48308.1 - 4e-10 39.4 39.3 0.014 15.3 2.3 5.8 5 0 0 5 5 5 4 C2H2-type zinc finger PyrI_C PF02748.15 PIK48308.1 - 3.1e-07 30.2 23.0 0.053 13.4 0.4 6.4 7 0 0 7 7 7 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.11 PIK48308.1 - 4.7e-06 26.3 1.5 0.1 12.4 0.1 4.0 1 1 3 4 4 4 2 GAGA factor zf-CHCC PF10276.9 PIK48308.1 - 0.00013 21.9 29.0 0.15 12.1 0.1 5.7 6 0 0 6 6 5 3 Zinc-finger domain zf-BED PF02892.15 PIK48308.1 - 0.0015 18.5 29.5 0.62 10.1 0.8 6.0 1 1 4 5 5 5 3 BED zinc finger C1_1 PF00130.22 PIK48308.1 - 0.027 14.4 23.3 1.2 9.0 3.1 5.3 2 1 4 6 6 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_4 PF07975.12 PIK48308.1 - 0.047 13.9 17.5 2.2 8.6 0.1 3.9 2 1 0 3 3 3 0 TFIIH C1-like domain zf-met PF12874.7 PIK48308.1 - 0.093 13.1 32.2 0.33 11.4 0.9 5.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 PIK48308.1 - 0.26 10.9 16.7 3.4 7.3 0.2 5.2 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 PIK48308.1 - 0.35 11.2 21.9 0.15 12.4 2.3 4.3 1 1 4 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 PIK48308.1 - 0.83 9.9 24.2 3.9 7.7 0.2 5.5 4 1 1 5 5 5 0 AN1-like Zinc finger zf-C2HC_2 PF13913.6 PIK48308.1 - 0.97 9.4 20.6 2.3 8.2 0.3 5.6 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 PIK48308.1 - 1 9.2 54.6 0.31 10.8 2.1 7.9 7 3 0 7 7 6 0 C2H2-type zinc-finger domain YyzF PF14116.6 PIK48308.1 - 1.6 8.8 17.9 25 5.0 0.2 5.3 6 0 0 6 6 5 0 YyzF-like protein zf_C2H2_6 PF18450.1 PIK48308.1 - 3.4 7.5 19.9 4.3 7.1 0.5 5.4 5 0 0 5 5 5 0 Zinc Finger domain zf-MYST PF17772.1 PIK48308.1 - 3.7 7.2 12.3 0.97 9.1 0.1 4.0 2 1 2 4 4 4 0 MYST family zinc finger domain HNH PF01844.23 PIK48308.1 - 5.4 7.3 17.5 25 5.1 0.3 5.3 5 0 0 5 5 5 0 HNH endonuclease zinc_ribbon_15 PF17032.5 PIK48308.1 - 7.5 7.4 24.6 0.58 11.0 2.4 3.8 1 1 3 5 5 5 0 zinc-ribbon family zf-Dof PF02701.15 PIK48308.1 - 9.3 6.5 12.2 5.2 7.3 0.1 4.0 2 1 2 4 4 4 0 Dof domain, zinc finger Yippee-Mis18 PF03226.14 PIK48308.1 - 9.5 6.5 11.6 54 4.1 0.2 3.6 2 1 1 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Methyltransf_31 PF13847.6 PIK48309.1 - 9e-25 87.2 0.0 1.2e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK48309.1 - 2.1e-15 57.1 0.0 4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48309.1 - 3.9e-15 56.3 0.0 8.7e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48309.1 - 1.7e-12 48.0 0.0 3.9e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK48309.1 - 3.2e-12 46.6 0.0 5e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK48309.1 - 2.7e-07 30.2 0.0 4.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 PIK48309.1 - 4.7e-07 29.4 0.0 7.2e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 PIK48309.1 - 5.8e-06 25.7 0.0 9.8e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 PIK48309.1 - 7e-06 25.7 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 PIK48309.1 - 0.00023 21.1 0.0 0.00047 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK48309.1 - 0.00097 18.5 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 PIK48309.1 - 0.0011 19.0 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 PIK48309.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 PIK48309.1 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 PIK48309.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 PIK48309.1 - 0.065 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RrnaAD PF00398.20 PIK48309.1 - 0.18 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 PIK48310.1 - 1.5e-25 89.8 0.0 1.8e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48310.1 - 5.1e-19 68.8 0.0 7.5e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK48310.1 - 6.1e-18 65.3 0.0 8.8e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48310.1 - 6e-15 55.8 0.0 1.1e-14 54.9 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK48310.1 - 3.7e-14 52.6 0.0 4.6e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK48310.1 - 5.5e-09 36.1 0.0 7.1e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK48310.1 - 4.4e-08 32.8 0.0 1e-07 31.6 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 PIK48310.1 - 1.6e-07 31.0 0.0 2.2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 PIK48310.1 - 4.3e-07 29.4 0.0 5.7e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_24 PF13578.6 PIK48310.1 - 3.5e-06 28.0 0.0 5.3e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK48310.1 - 1.3e-05 25.1 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 PIK48310.1 - 4.2e-05 23.2 0.0 7e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW GidB PF02527.15 PIK48310.1 - 0.00012 21.5 0.0 0.00014 21.2 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.6 PIK48310.1 - 0.00058 19.9 0.0 0.00063 19.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK48310.1 - 0.0063 15.9 0.0 0.0074 15.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK48310.1 - 0.0078 16.2 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 PIK48310.1 - 0.0095 16.1 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.15 PIK48310.1 - 0.053 13.4 0.0 1.5 8.6 0.0 2.4 2 1 0 2 2 2 0 Hypothetical methyltransferase TehB PF03848.14 PIK48310.1 - 0.056 12.9 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB CMAS PF02353.20 PIK48310.1 - 0.22 10.8 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 PIK48311.1 - 1.2e-24 86.9 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48311.1 - 1.2e-18 67.5 0.0 2.1e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK48311.1 - 1.2e-17 64.3 0.0 2.1e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48311.1 - 2.1e-14 54.0 0.0 3.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK48311.1 - 2.3e-14 53.3 0.0 3.8e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK48311.1 - 1e-08 35.2 0.0 1.4e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 PIK48311.1 - 1.4e-06 29.3 0.0 3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK48311.1 - 3e-06 26.9 0.0 4.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK48311.1 - 7.2e-06 25.6 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 PIK48311.1 - 8.2e-06 25.7 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 PIK48311.1 - 2.7e-05 23.6 0.0 4.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain MetW PF07021.12 PIK48311.1 - 5.7e-05 22.8 0.0 9.7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 PIK48311.1 - 0.00052 20.0 0.0 0.00083 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 PIK48311.1 - 0.0036 16.7 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_18 PF12847.7 PIK48311.1 - 0.0039 17.1 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK48311.1 - 0.012 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 PIK48311.1 - 0.012 15.7 0.0 0.021 15.0 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase CMAS PF02353.20 PIK48311.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TehB PF03848.14 PIK48311.1 - 0.19 11.1 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_31 PF13847.6 PIK48312.1 - 1.3e-25 90.0 0.0 1.5e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48312.1 - 5.1e-19 68.8 0.0 7.9e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK48312.1 - 1.1e-17 64.5 0.0 1.7e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48312.1 - 2.9e-15 56.8 0.0 5.5e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK48312.1 - 3.4e-14 52.7 0.0 4.8e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 PIK48312.1 - 1.2e-09 38.3 0.0 1.4e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK48312.1 - 7.1e-08 32.1 0.0 1.5e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 PIK48312.1 - 3.4e-07 30.0 0.0 4.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 PIK48312.1 - 5.5e-07 29.1 0.0 7.6e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_24 PF13578.6 PIK48312.1 - 1.2e-06 29.5 0.0 1.8e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK48312.1 - 0.00011 22.0 0.0 0.00016 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 PIK48312.1 - 0.0002 21.4 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 PIK48312.1 - 0.0008 18.8 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MetW PF07021.12 PIK48312.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.4 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 PIK48312.1 - 0.013 14.9 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK48312.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.5 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 PIK48312.1 - 0.023 14.5 0.0 0.45 10.3 0.0 2.0 1 1 0 1 1 1 0 Hypothetical methyltransferase PID PF00640.23 PIK48313.1 - 1.5e-38 132.0 0.1 3.1e-38 131.0 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 PIK48313.1 - 1.6e-10 41.2 0.1 5.5e-10 39.5 0.1 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK48313.1 - 0.00043 20.1 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK48313.1 - 0.021 15.1 0.0 0.051 13.9 0.0 1.6 1 0 0 1 1 1 0 PDZ domain SIN1_PH PF16979.5 PIK48313.1 - 0.025 14.8 0.0 2 8.7 0.1 2.6 2 0 0 2 2 2 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PDZ PF00595.24 PIK48314.1 - 5.2e-10 39.5 0.2 6.4e-10 39.3 0.2 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK48314.1 - 1.6e-08 34.3 0.1 1.9e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 PDZ domain NRho PF16733.5 PIK48314.1 - 0.0083 16.2 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Rhomboid N-terminal domain LRAT PF04970.13 PIK48315.1 - 7.2e-05 23.1 4.7 0.0053 17.1 4.7 2.8 1 1 0 1 1 1 1 Lecithin retinol acyltransferase IQ PF00612.27 PIK48317.1 - 0.00021 20.8 0.1 0.0006 19.4 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Homeodomain PF00046.29 PIK48318.1 - 0.0015 18.4 4.9 0.0034 17.2 4.9 1.6 1 0 0 1 1 1 1 Homeodomain IBN_N PF03810.19 PIK48319.1 - 4.3e-15 55.4 0.0 2.1e-14 53.2 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Sep15_SelM PF08806.11 PIK48320.1 - 0.01 16.0 0.5 0.022 14.9 0.5 1.4 1 0 0 1 1 1 0 Sep15/SelM redox domain DUF4132 PF13569.6 PIK48320.1 - 0.068 13.0 0.2 0.47 10.2 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4132) FKS1_dom1 PF14288.6 PIK48320.1 - 0.23 11.8 3.9 0.7 10.2 3.9 1.9 1 1 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Sugar_tr PF00083.24 PIK48321.1 - 0.0045 15.9 11.7 0.0054 15.6 11.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter GMC_oxred_C PF05199.13 PIK48322.1 - 5.5e-14 52.9 0.1 1.8e-13 51.3 0.0 1.9 2 0 0 2 2 2 1 GMC oxidoreductase Abhydrolase_1 PF00561.20 PIK48322.1 - 1.6e-06 28.0 0.1 2.7e-05 24.0 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK48322.1 - 0.00085 18.7 0.0 0.026 13.8 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK48322.1 - 0.0015 19.2 0.0 0.0029 18.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family GMC_oxred_N PF00732.19 PIK48322.1 - 0.021 14.2 0.0 4.5 6.6 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase HECT PF00632.25 PIK48323.1 - 3.6e-13 49.7 0.2 1.9e-12 47.3 0.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) HECT PF00632.25 PIK48324.1 - 1.1e-67 228.8 0.1 1.2e-67 228.6 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ARID PF01388.21 PIK48324.1 - 0.12 13.1 0.0 0.39 11.4 0.0 2.0 1 1 0 1 1 1 0 ARID/BRIGHT DNA binding domain adh_short PF00106.25 PIK48325.1 - 1.4e-39 135.6 0.0 1.9e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK48325.1 - 5.3e-24 85.1 0.0 7.4e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 PIK48325.1 - 1.7e-05 24.4 0.1 3.2e-05 23.5 0.1 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 PIK48325.1 - 0.00089 19.2 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF4471 PF14740.6 PIK48326.1 - 7.1e-68 229.1 0.3 1e-67 228.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) DUF4470 PF14737.6 PIK48326.1 - 2.7e-24 85.2 0.0 4.8e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) CUB PF00431.20 PIK48327.1 - 2.3e-45 153.4 0.1 4.3e-18 65.7 0.0 3.6 3 0 0 3 3 3 3 CUB domain Ldl_recept_a PF00057.18 PIK48327.1 - 3e-38 129.7 98.5 1.4e-10 41.2 10.9 9.2 9 1 1 10 10 8 7 Low-density lipoprotein receptor domain class A 7tm_1 PF00001.21 PIK48327.1 - 9.9e-33 113.6 13.0 1.5e-32 113.0 13.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK48327.1 - 4.8e-23 80.7 23.3 2.4e-12 46.4 5.1 4.1 2 1 2 4 4 3 3 Leucine rich repeat Lectin_C PF00059.21 PIK48327.1 - 3.7e-16 59.8 6.1 7.9e-14 52.3 3.3 2.8 2 0 0 2 2 2 2 Lectin C-type domain LRR_5 PF13306.6 PIK48327.1 - 2.5e-11 43.7 0.0 1e-10 41.7 0.0 2.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK48327.1 - 5e-08 33.1 20.0 0.0031 17.9 1.0 4.7 1 1 2 4 4 4 2 Leucine Rich repeats (2 copies) EGF_CA PF07645.15 PIK48327.1 - 1.6e-06 28.2 5.7 1.6e-06 28.2 5.7 6.7 5 2 1 6 6 3 1 Calcium-binding EGF domain CUB_2 PF02408.20 PIK48327.1 - 1.9e-06 27.6 0.2 0.094 12.5 0.0 3.3 3 1 0 3 3 3 2 CUB-like domain 7TM_GPCR_Srx PF10328.9 PIK48327.1 - 1.9e-05 24.4 7.0 3.5e-05 23.6 7.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx FXa_inhibition PF14670.6 PIK48327.1 - 3.1e-05 24.2 6.7 3.1e-05 24.2 6.7 3.4 3 0 0 3 3 1 1 Coagulation Factor Xa inhibitory site 7TM_GPCR_Srv PF10323.9 PIK48327.1 - 0.00011 21.7 6.9 0.00018 21.0 6.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv LRR_1 PF00560.33 PIK48327.1 - 0.00014 21.9 11.3 1.5 9.7 0.0 6.3 5 0 0 5 5 4 1 Leucine Rich Repeat cEGF PF12662.7 PIK48327.1 - 0.011 15.6 1.3 0.011 15.6 1.3 4.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like LRR_9 PF14580.6 PIK48327.1 - 0.014 14.9 1.5 0.27 10.7 0.2 2.0 1 1 1 2 2 2 0 Leucine-rich repeat Git3 PF11710.8 PIK48327.1 - 0.036 13.8 11.7 0.049 13.4 10.7 1.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Ceramidase PF05875.12 PIK48327.1 - 0.037 13.5 3.7 0.17 11.3 0.0 2.9 3 0 0 3 3 3 0 Ceramidase Serpentine_r_xa PF03383.15 PIK48327.1 - 0.05 13.6 0.7 0.13 12.2 0.7 1.6 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa LRR_6 PF13516.6 PIK48327.1 - 0.65 10.2 8.7 4 7.7 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich repeat F5_F8_type_C PF00754.25 PIK48328.1 - 5.5e-15 55.6 0.2 6e-09 36.1 0.1 3.1 3 0 0 3 3 3 3 F5/8 type C domain TIP41 PF04176.13 PIK48329.1 - 2.6e-64 215.8 0.3 3.3e-64 215.5 0.3 1.1 1 0 0 1 1 1 1 TIP41-like family Acid_PPase PF12689.7 PIK48329.1 - 0.0044 16.9 0.5 0.0064 16.3 0.1 1.5 2 0 0 2 2 2 1 Acid Phosphatase DUF3953 PF13129.6 PIK48330.1 - 1.4 8.7 5.3 0.39 10.5 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) DUF3040 PF11239.8 PIK48330.1 - 1.4 9.2 4.4 1.5 9.1 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) AA_permease_2 PF13520.6 PIK48331.1 - 3.5e-63 213.9 32.6 4.3e-63 213.6 32.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK48331.1 - 1.7e-27 96.2 34.3 2.2e-27 95.8 34.3 1.1 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.12 PIK48331.1 - 0.03 14.4 0.2 0.03 14.4 0.2 2.7 3 0 0 3 3 3 0 Invasion gene expression up-regulator, SirB NHL PF01436.21 PIK48332.1 - 8.4e-23 79.2 11.3 0.00022 21.1 2.0 6.0 5 0 0 5 5 5 5 NHL repeat DUF5128 PF17170.4 PIK48332.1 - 1.2e-13 50.9 1.0 1.5e-06 27.6 0.0 3.3 1 1 2 3 3 3 3 6-bladed beta-propeller zf-B_box PF00643.24 PIK48332.1 - 2.4e-07 30.8 12.6 2.4e-07 30.8 12.6 3.2 3 0 0 3 3 3 2 B-box zinc finger SGL PF08450.12 PIK48332.1 - 3.2e-05 23.6 0.7 0.57 9.7 0.1 3.1 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DUF4934 PF16288.5 PIK48332.1 - 0.00086 19.2 5.8 0.7 9.8 0.1 3.5 1 1 2 3 3 3 2 Domain of unknown function (DUF4934) Phytase-like PF13449.6 PIK48332.1 - 0.025 14.5 0.0 0.24 11.3 0.0 2.7 1 1 0 1 1 1 0 Esterase-like activity of phytase DUF3583 PF12126.8 PIK48332.1 - 0.2 11.1 1.6 0.29 10.6 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) PGAP1 PF07819.13 PIK48333.1 - 0.026 14.2 0.1 0.092 12.4 0.1 1.8 2 0 0 2 2 2 0 PGAP1-like protein UBD PF16455.5 PIK48334.1 - 1.1e-15 57.7 0.1 9.6e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-binding domain ubiquitin PF00240.23 PIK48334.1 - 5.3e-14 51.7 0.5 9.5e-14 50.9 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 PIK48334.1 - 1.1e-09 37.9 0.1 1.9e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 PIK48334.1 - 0.1 12.7 0.1 0.23 11.6 0.1 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like IGR PF09597.10 PIK48334.1 - 0.11 12.6 0.1 0.5 10.5 0.0 2.0 2 0 0 2 2 2 0 IGR protein motif MMS19_N PF14500.6 PIK48335.1 - 1.6e-85 286.8 2.0 4.1e-80 269.1 0.1 3.8 3 1 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 PIK48335.1 - 2.7e-75 254.1 12.8 3.2e-71 240.7 0.3 3.5 4 0 0 4 4 4 3 RNAPII transcription regulator C-terminal HEAT PF02985.22 PIK48335.1 - 3.5e-08 33.0 7.6 0.033 14.4 0.0 6.0 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.7 PIK48335.1 - 1.5e-07 31.6 3.5 0.00022 21.3 0.1 4.5 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK48335.1 - 4.6e-07 30.1 4.1 0.069 13.5 0.1 5.1 5 1 0 5 5 5 2 HEAT repeats RTP1_C1 PF10363.9 PIK48335.1 - 0.00084 19.5 4.6 0.39 10.9 0.2 4.8 6 1 1 7 7 7 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 PIK48335.1 - 0.0036 17.3 0.2 0.43 10.7 0.0 4.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK48335.1 - 0.006 17.1 13.1 0.69 10.5 0.0 6.6 5 2 2 7 7 7 2 HEAT-like repeat DUF4042 PF13251.6 PIK48335.1 - 0.06 13.1 0.3 8.6 6.0 0.2 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4042) RT_RNaseH PF17917.1 PIK48336.1 - 1.6e-29 102.3 0.0 4.5e-29 100.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48336.1 - 5.9e-26 91.3 0.0 1.3e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48336.1 - 9.2e-26 89.8 0.0 5.8e-25 87.2 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48336.1 - 3e-21 75.8 0.0 8.1e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48336.1 - 5.6e-15 55.2 1.1 2.9e-14 52.9 0.2 2.8 4 0 0 4 4 4 1 Integrase zinc binding domain rve_3 PF13683.6 PIK48336.1 - 0.00018 21.2 0.0 0.00056 19.6 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain SRCR PF00530.18 PIK48337.1 - 7.9e-98 321.5 18.8 2.5e-27 95.3 0.8 4.0 3 1 1 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48337.1 - 3.6e-23 81.9 12.1 3.1e-05 24.4 0.3 4.3 3 1 1 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48337.1 - 1.2e-18 67.6 0.0 0.0023 18.4 0.0 4.3 3 1 1 4 4 4 4 Hepsin, SRCR domain Bac_chlorC PF02043.17 PIK48337.1 - 5.5e-06 26.3 1.4 8.3 6.5 0.0 4.3 4 0 0 4 4 4 3 Bacteriochlorophyll C binding protein BetaGal_dom4_5 PF13364.6 PIK48337.1 - 0.0021 18.6 0.5 32 5.1 0.0 4.0 4 0 0 4 4 4 0 Beta-galactosidase jelly roll domain SapB_2 PF03489.17 PIK48337.1 - 0.048 13.8 0.1 2e+02 2.2 0.0 4.1 4 0 0 4 4 4 0 Saposin-like type B, region 2 DUF1759 PF03564.15 PIK48339.1 - 0.00021 21.3 0.0 0.0004 20.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DUF4358 PF14270.6 PIK48339.1 - 0.015 15.5 0.1 8.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) SRCR PF00530.18 PIK48340.1 - 1.7e-70 233.8 2.0 1.1e-27 96.5 0.5 3.1 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48340.1 - 5e-18 65.4 1.1 0.0003 21.3 0.0 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48340.1 - 1.7e-12 47.8 0.0 0.016 15.7 0.0 3.3 3 0 0 3 3 3 3 Hepsin, SRCR domain Bac_chlorC PF02043.17 PIK48340.1 - 0.0004 20.3 0.3 16 5.6 0.0 3.3 3 0 0 3 3 3 3 Bacteriochlorophyll C binding protein BetaGal_dom4_5 PF13364.6 PIK48340.1 - 0.00053 20.5 0.5 2.9 8.5 0.1 3.3 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain SapB_2 PF03489.17 PIK48340.1 - 0.099 12.8 0.0 1.1e+02 3.1 0.0 3.5 3 0 0 3 3 3 0 Saposin-like type B, region 2 DUF3195 PF11424.8 PIK48340.1 - 0.15 12.1 0.1 1.2e+02 2.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3195) Peptidase_C50 PF03568.17 PIK48340.1 - 1.3 8.1 3.8 23 4.0 0.1 2.8 3 0 0 3 3 3 0 Peptidase family C50 SRCR PF00530.18 PIK48341.1 - 1.5e-26 92.8 0.5 1.9e-26 92.5 0.5 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48341.1 - 8.5e-05 23.0 0.3 0.00012 22.5 0.3 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48341.1 - 0.0045 17.5 0.0 0.0056 17.2 0.0 1.3 1 1 0 1 1 1 1 Hepsin, SRCR domain SRCR PF00530.18 PIK48342.1 - 1.3e-150 490.9 25.6 2.2e-26 92.2 0.7 6.2 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48342.1 - 5.9e-29 100.5 10.3 0.00061 20.3 0.1 6.4 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48342.1 - 4.6e-18 65.8 1.8 0.037 14.6 0.0 7.3 7 1 0 7 7 7 5 Hepsin, SRCR domain HYR PF02494.16 PIK48342.1 - 0.033 14.5 0.0 0.08 13.3 0.0 1.6 1 0 0 1 1 1 0 HYR domain SRCR PF00530.18 PIK48343.1 - 4.1e-153 498.9 30.6 4.2e-26 91.4 0.6 6.2 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48343.1 - 7.6e-30 103.3 11.7 0.0003 21.3 0.3 6.4 6 0 0 6 6 6 6 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48343.1 - 2.2e-19 70.0 0.7 0.034 14.7 0.0 6.5 6 0 0 6 6 6 6 Hepsin, SRCR domain NeuB PF03102.14 PIK48344.1 - 2.9e-77 259.4 0.0 3.6e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 PIK48344.1 - 4.6e-06 27.2 0.1 9.8e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 SAF domain DUF2458 PF10454.9 PIK48344.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) CHAD PF05235.14 PIK48344.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.5 1 1 0 1 1 1 0 CHAD domain OFCC1 PF15680.5 PIK48345.1 - 0.047 14.2 2.9 15 6.2 0.2 3.7 1 1 2 3 3 3 0 Orofacial cleft 1 candidate gene 1 protein DUF3106 PF11304.8 PIK48345.1 - 0.099 13.1 7.4 0.18 12.3 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) Galactosyl_T PF01762.21 PIK48346.1 - 5.9e-41 140.4 0.6 7e-41 140.2 0.6 1.1 1 0 0 1 1 1 1 Galactosyltransferase Neur_chan_LBD PF02931.23 PIK48347.1 - 6e-43 146.8 1.1 7.5e-43 146.5 1.1 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 PIK48348.1 - 6.3e-40 136.9 0.3 8.4e-40 136.5 0.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain R3H PF01424.22 PIK48349.1 - 2e-08 34.1 0.2 5.2e-08 32.8 0.2 1.8 1 0 0 1 1 1 1 R3H domain RNA_bind PF08675.11 PIK48349.1 - 4.2e-05 23.5 0.0 8.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain NCBP3 PF10309.9 PIK48349.1 - 0.0014 18.4 0.1 0.0026 17.6 0.1 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 UPF0561 PF10573.9 PIK48349.1 - 0.0034 17.5 1.9 0.0034 17.5 1.9 4.0 4 1 1 5 5 5 1 Uncharacterised protein family UPF0561 RP-C_C PF11800.8 PIK48350.1 - 0.57 10.3 2.2 0.63 10.1 2.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region SPATA24 PF15175.6 PIK48351.1 - 2.9e-34 118.6 30.0 3.7e-34 118.2 30.0 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 HycH PF07450.11 PIK48351.1 - 0.75 10.2 10.3 0.19 12.1 4.8 2.1 1 1 2 3 3 3 0 Formate hydrogenlyase maturation protein HycH WD40 PF00400.32 PIK48352.1 - 6.1e-12 45.9 5.5 1.4e-06 28.9 0.2 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48352.1 - 7.2e-05 23.0 0.5 0.083 13.2 0.1 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK48352.1 - 0.00031 19.5 1.9 0.061 12.0 0.3 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK48352.1 - 0.053 13.4 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 PIK48353.1 - 6e-16 58.5 0.5 6.6e-07 29.9 0.0 2.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48353.1 - 0.0019 18.4 0.0 0.0087 16.3 0.0 1.9 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK48353.1 - 0.055 12.8 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain Nucleoporin_N PF08801.11 PIK48353.1 - 0.12 11.1 0.0 2.3 6.9 0.0 1.9 1 1 1 2 2 2 0 Nup133 N terminal like FUSC PF04632.12 PIK48354.1 - 0.054 12.0 3.7 0.078 11.5 3.7 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family KASH_CCD PF14662.6 PIK48354.1 - 0.19 11.5 77.7 0.062 13.1 20.3 3.7 2 2 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH FOXP-CC PF16159.5 PIK48354.1 - 3.2 8.5 6.9 0.79 10.4 1.2 2.8 2 0 0 2 2 2 0 FOXP coiled-coil domain RNB PF00773.19 PIK48355.1 - 8.2e-45 153.5 0.0 2.4e-39 135.6 0.1 2.1 2 0 0 2 2 2 2 RNB domain OB_Dis3 PF17849.1 PIK48355.1 - 5.2e-21 74.5 0.0 1.3e-20 73.1 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 PIK48355.1 - 1.3e-08 34.7 0.0 2.6e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 PIK48355.1 - 0.028 14.6 0.0 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Cold shock domain Integrase_H2C2 PF17921.1 PIK48356.1 - 0.0026 17.8 1.5 0.005 16.9 1.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK48356.1 - 0.016 15.4 0.5 0.031 14.5 0.5 1.5 1 0 0 1 1 1 0 H2C2 zinc finger SpecificRecomb PF10136.9 PIK48357.1 - 0.071 11.4 0.0 0.098 11.0 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase HRG PF16954.5 PIK48358.1 - 0.16 12.4 1.9 18 5.8 0.3 3.1 2 0 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Voltage_CLC PF00654.20 PIK48359.1 - 8.5e-92 308.1 29.0 1e-91 307.9 25.9 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 PIK48359.1 - 7.7e-06 26.3 0.6 0.035 14.6 0.0 3.3 3 0 0 3 3 3 2 CBS domain MAM PF00629.23 PIK48360.1 - 1.5e-21 77.0 5.9 1.1e-13 51.4 0.0 2.1 1 1 1 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK48360.1 - 7.3e-06 26.1 5.9 7.3e-06 26.1 5.9 1.7 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK48361.1 - 2.7e-23 82.7 0.0 4.8e-23 81.8 0.0 1.4 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK48361.1 - 7.9e-05 22.8 3.0 7.9e-05 22.8 3.0 1.7 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Methyltransf_5 PF01795.19 PIK48362.1 - 4.1e-24 85.6 0.0 2.3e-23 83.2 0.0 1.8 1 1 0 1 1 1 1 MraW methylase family Choline_kinase PF01633.20 PIK48363.1 - 7.6e-58 195.6 0.2 1.4e-57 194.7 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 PIK48363.1 - 2.7e-11 43.8 0.0 4.5e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family I-set PF07679.16 PIK48364.1 - 3.4e-10 39.9 3.7 1.4e-08 34.7 0.5 2.8 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK48364.1 - 5.5e-10 39.7 8.3 1.4e-08 35.2 0.3 2.9 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK48364.1 - 1.5e-09 37.9 5.3 2.7e-07 30.7 0.5 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK48364.1 - 1.7e-06 28.3 3.7 4.3e-05 23.8 0.2 2.8 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK48364.1 - 0.00052 20.0 0.3 1.6 8.8 0.0 3.0 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK48364.1 - 0.0023 18.1 0.5 0.0023 18.1 0.5 2.6 3 1 0 3 3 3 1 Immunoglobulin V-set domain CEL_III_C PF18054.1 PIK48364.1 - 0.062 13.4 0.5 0.062 13.4 0.5 1.9 2 0 0 2 2 2 0 CEL-III C-terminal DNA_ligase_ZBD PF03119.16 PIK48364.1 - 0.14 12.2 0.0 3.6 7.7 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain FmiP_Thoc5 PF09766.9 PIK48364.1 - 0.18 11.1 0.1 0.24 10.6 0.1 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Big_8 PF17961.1 PIK48365.1 - 0.007 16.5 0.8 0.016 15.3 0.8 1.6 1 0 0 1 1 1 1 Bacterial Ig domain PMP1_2 PF08114.11 PIK48365.1 - 0.029 14.1 0.5 0.051 13.3 0.5 1.3 1 0 0 1 1 1 0 ATPase proteolipid family 7tm_1 PF00001.21 PIK48366.1 - 5.9e-27 94.6 10.0 7.1e-27 94.4 10.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK48366.1 - 0.00019 21.3 6.8 0.00042 20.1 6.8 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK48366.1 - 0.017 14.8 8.9 0.029 14.0 7.4 1.9 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Sri PF10327.9 PIK48366.1 - 0.025 13.8 6.0 0.032 13.4 6.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri NPCC PF08058.11 PIK48366.1 - 0.19 11.8 1.7 0.39 10.8 0.9 1.8 2 0 0 2 2 2 0 Nuclear pore complex component zf-H2C2_2 PF13465.6 PIK48367.1 - 2.6e-13 49.7 28.8 6.5e-08 32.7 1.1 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK48367.1 - 4.9e-09 36.3 20.0 0.00018 22.0 1.5 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48367.1 - 2.3e-08 34.1 10.8 0.00046 20.4 0.1 3.8 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 PIK48367.1 - 1.6e-07 31.3 20.6 2.3e-05 24.6 1.5 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.7 PIK48367.1 - 0.0029 17.9 0.6 0.0029 17.9 0.6 3.7 4 0 0 4 4 3 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK48367.1 - 0.016 15.5 7.9 0.79 10.1 7.9 2.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.8 PIK48367.1 - 0.031 14.6 5.6 0.095 13.0 2.4 2.3 1 1 1 2 2 2 0 zinc-finger-containing domain zf-C2H2_11 PF16622.5 PIK48367.1 - 0.038 13.7 0.2 0.038 13.7 0.2 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type Rpr2 PF04032.16 PIK48367.1 - 0.15 12.3 4.5 7.7 6.9 0.0 2.3 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn-ribbon_8 PF09723.10 PIK48367.1 - 0.21 11.7 11.3 3 8.1 0.1 3.3 2 1 1 3 3 3 0 Zinc ribbon domain CDC24_OB3 PF17244.2 PIK48367.1 - 0.68 9.6 6.0 16 5.1 6.0 2.6 1 1 0 1 1 1 0 Cell division control protein 24, OB domain 3 zf-BED PF02892.15 PIK48367.1 - 0.74 9.9 14.6 1.4 9.0 0.5 3.7 2 1 2 4 4 4 0 BED zinc finger C1_4 PF07975.12 PIK48367.1 - 0.75 10.1 15.2 0.47 10.7 1.5 2.8 2 1 2 4 4 3 0 TFIIH C1-like domain Zf_RING PF16744.5 PIK48367.1 - 1.2 9.4 8.5 16 5.7 0.2 3.3 1 1 2 3 3 3 0 KIAA1045 RING finger PyrI_C PF02748.15 PIK48367.1 - 2.1 8.3 13.3 1.6 8.7 1.5 3.6 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain YyzF PF14116.6 PIK48367.1 - 2.2 8.4 9.6 15 5.7 0.2 4.1 4 1 0 4 4 4 0 YyzF-like protein zf-H2C2_2 PF13465.6 PIK48368.1 - 3.2e-12 46.3 25.2 7.5e-09 35.6 1.8 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48368.1 - 2.9e-07 30.6 16.4 0.00033 20.9 1.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48368.1 - 8.8e-07 29.2 22.3 0.0051 17.5 1.4 3.9 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48368.1 - 5.2e-06 26.6 7.2 0.011 16.0 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding C1_4 PF07975.12 PIK48368.1 - 0.0011 19.2 6.6 0.18 12.1 0.0 2.7 3 0 0 3 3 3 2 TFIIH C1-like domain DUF3268 PF11672.8 PIK48368.1 - 0.002 18.4 2.9 0.4 11.0 0.1 3.1 2 1 1 3 3 3 2 zinc-finger-containing domain PyrI_C PF02748.15 PIK48368.1 - 0.015 15.2 5.1 10 6.1 0.2 3.6 1 1 2 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 PIK48368.1 - 0.22 12.0 5.9 9 6.8 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK48368.1 - 0.43 10.9 0.2 0.43 10.9 0.2 2.5 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding C5HCH PF17982.1 PIK48368.1 - 0.74 10.0 5.6 4.6 7.5 0.2 3.3 3 0 0 3 3 3 0 NSD Cys-His rich domain Zf_RING PF16744.5 PIK48368.1 - 0.95 9.6 3.8 3.4 7.8 0.1 3.0 1 1 2 3 3 3 0 KIAA1045 RING finger zf-AN1 PF01428.16 PIK48368.1 - 1.1 9.4 13.7 12 6.2 0.2 3.6 2 1 0 3 3 3 0 AN1-like Zinc finger zf_C2H2_6 PF18450.1 PIK48368.1 - 2.3 8.0 7.2 12 5.7 0.2 3.3 3 0 0 3 3 3 0 Zinc Finger domain FYVE PF01363.21 PIK48368.1 - 4.7 7.4 11.5 9.5 6.4 8.8 2.8 2 1 1 3 3 3 0 FYVE zinc finger zf-H2C2_2 PF13465.6 PIK48369.1 - 9.3e-10 38.5 15.2 1.4e-06 28.5 4.6 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48369.1 - 0.00011 22.4 30.7 0.026 15.0 0.8 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48369.1 - 0.0011 19.7 30.0 0.22 12.5 0.9 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger PyrI_C PF02748.15 PIK48369.1 - 0.0023 17.8 8.0 0.77 9.7 1.2 3.4 2 1 1 3 3 3 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_4 PF07975.12 PIK48369.1 - 0.0091 16.2 8.7 0.51 10.6 0.0 2.6 2 1 0 2 2 2 1 TFIIH C1-like domain DUF3268 PF11672.8 PIK48369.1 - 0.22 11.9 0.3 0.22 11.9 0.3 2.2 1 1 1 2 2 2 0 zinc-finger-containing domain FYVE PF01363.21 PIK48369.1 - 1.4 9.2 15.2 1.1 9.5 13.5 1.8 1 1 0 1 1 1 0 FYVE zinc finger zf-H2C2_2 PF13465.6 PIK48370.1 - 3.7e-19 68.2 19.5 8.6e-10 38.6 1.0 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48370.1 - 1e-09 38.3 19.3 0.001 19.4 1.2 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48370.1 - 2.2e-09 37.3 18.5 0.0064 17.2 1.4 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger C1_4 PF07975.12 PIK48370.1 - 0.0013 18.9 7.8 0.053 13.8 0.4 3.2 1 1 2 3 3 3 1 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 PIK48370.1 - 0.0016 18.7 9.4 1.4 9.3 1.3 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK48370.1 - 0.037 14.0 15.3 2.1 8.4 3.1 3.9 3 1 0 3 3 3 0 C2H2-type zinc finger DUF3268 PF11672.8 PIK48370.1 - 0.048 14.0 3.8 0.06 13.7 0.3 2.1 1 1 1 2 2 2 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.10 PIK48370.1 - 0.053 13.7 10.1 0.35 11.0 2.5 2.7 1 1 2 3 3 3 0 Zinc ribbon domain zf-met PF12874.7 PIK48370.1 - 0.33 11.4 14.1 0.22 12.0 2.6 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Lar_restr_allev PF14354.6 PIK48370.1 - 0.43 11.0 6.0 4.9 7.6 3.7 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar Zf_RING PF16744.5 PIK48370.1 - 0.73 10.0 9.3 2.1 8.5 0.7 3.2 1 1 2 3 3 3 0 KIAA1045 RING finger zf-AN1 PF01428.16 PIK48370.1 - 0.77 10.0 17.3 0.45 10.7 2.1 3.4 2 2 1 3 3 3 0 AN1-like Zinc finger zinc-ribbons_6 PF07191.12 PIK48370.1 - 0.82 9.7 7.5 5.8 7.0 2.4 2.7 1 1 1 2 2 2 0 zinc-ribbons UBZ_FAAP20 PF15750.5 PIK48370.1 - 1.2 9.1 6.4 9.9 6.2 0.3 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger DNA_RNApol_7kD PF03604.13 PIK48370.1 - 1.5 8.6 7.5 8.6 6.1 1.1 2.9 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Vps39_2 PF10367.9 PIK48370.1 - 1.8 9.0 7.3 13 6.2 0.4 3.1 1 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 2 zf-Di19 PF05605.12 PIK48370.1 - 3.5 8.0 12.8 2.1 8.7 6.4 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.6 PIK48370.1 - 4 7.5 7.7 3.7 7.6 0.1 2.7 2 1 0 2 2 2 0 CpXC protein TFIIS_C PF01096.18 PIK48370.1 - 4.5 7.2 8.7 7.9 6.4 0.5 3.0 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) A2L_zn_ribbon PF08792.10 PIK48370.1 - 6.9 6.5 8.0 5.2 6.9 0.1 3.0 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-C2H2_2 PF12756.7 PIK48370.1 - 8.9 6.7 11.4 6.5 7.2 2.8 2.9 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) PHD PF00628.29 PIK48370.1 - 9.8 6.2 10.9 2.5 8.1 0.4 3.2 3 1 0 3 3 3 0 PHD-finger zf-H2C2_2 PF13465.6 PIK48371.1 - 3.5e-18 65.1 11.3 1.3e-07 31.7 4.6 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48371.1 - 8.3e-08 32.3 15.2 0.068 13.7 0.8 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48371.1 - 1.3e-06 28.7 14.7 0.079 13.8 2.9 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48371.1 - 0.00012 22.2 8.2 0.14 12.5 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK48371.1 - 0.0017 18.2 11.9 0.043 13.7 1.4 3.4 3 0 0 3 3 3 2 zinc-finger of a C2HC-type PyrI_C PF02748.15 PIK48371.1 - 0.0042 17.0 3.5 1.6 8.7 0.8 3.1 3 0 0 3 3 3 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-AN1 PF01428.16 PIK48371.1 - 0.0067 16.6 14.4 1 9.6 3.0 3.3 2 1 1 3 3 3 2 AN1-like Zinc finger C1_4 PF07975.12 PIK48371.1 - 0.0091 16.2 5.6 1.3 9.3 7.1 2.7 1 1 1 2 2 2 1 TFIIH C1-like domain zf-C2H2_6 PF13912.6 PIK48371.1 - 0.01 15.8 12.7 0.82 9.7 0.3 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.15 PIK48371.1 - 0.021 14.8 8.2 0.38 10.8 0.4 3.3 1 1 2 3 3 3 0 BED zinc finger zf-C2H2_3rep PF18868.1 PIK48371.1 - 0.043 14.5 6.2 1.1 9.9 0.3 3.0 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 PIK48371.1 - 0.057 13.8 4.2 0.079 13.3 0.4 2.2 1 1 1 2 2 2 0 zinc-finger-containing domain LIM PF00412.22 PIK48371.1 - 0.1 12.8 11.0 1.7 9.0 3.0 3.1 1 1 0 2 2 2 0 LIM domain C1_1 PF00130.22 PIK48371.1 - 0.17 11.8 8.2 1.8 8.5 1.6 2.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2256 PF10013.9 PIK48371.1 - 0.18 11.9 6.0 4.9 7.4 0.1 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-trcl PF13451.6 PIK48371.1 - 0.19 11.6 5.4 7.7 6.5 0.1 3.3 3 0 0 3 3 3 0 Probable zinc-ribbon domain Zf_RING PF16744.5 PIK48371.1 - 0.27 11.4 7.2 6.1 7.0 0.1 3.1 1 1 2 3 3 3 0 KIAA1045 RING finger zf-met PF12874.7 PIK48371.1 - 0.57 10.7 8.8 7.2 7.2 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK48371.1 - 0.61 10.4 8.9 0.5 10.7 2.0 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CHCC PF10276.9 PIK48371.1 - 0.82 9.8 8.9 17 5.6 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger domain zf-C2HE PF16278.5 PIK48371.1 - 0.97 9.9 9.0 43 4.7 0.0 3.2 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc-ribbons_6 PF07191.12 PIK48371.1 - 1 9.4 6.3 35 4.5 0.3 2.7 1 1 1 2 2 2 0 zinc-ribbons XPA_N PF01286.18 PIK48371.1 - 1.2 9.2 6.4 11 6.2 0.1 3.1 3 0 0 3 3 3 0 XPA protein N-terminal FYVE PF01363.21 PIK48371.1 - 1.2 9.3 10.2 1.6 8.9 1.8 2.4 1 1 1 2 2 2 0 FYVE zinc finger Yippee-Mis18 PF03226.14 PIK48371.1 - 1.9 8.7 5.8 1.1 9.5 0.1 2.6 1 1 1 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf_UBZ PF18439.1 PIK48371.1 - 2.9 7.6 5.1 26 4.5 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Elf1 PF05129.13 PIK48371.1 - 4.2 7.5 11.8 14 5.8 6.8 2.8 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like UBZ_FAAP20 PF15750.5 PIK48371.1 - 5 7.1 5.8 32 4.6 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger DCAF17 PF15802.5 PIK48372.1 - 1.8e-82 277.6 11.0 7.1e-63 212.9 3.6 2.3 1 1 1 2 2 2 2 DDB1- and CUL4-associated factor 17 GRAM PF02893.20 PIK48372.1 - 0.0048 16.8 0.1 7.6 6.4 0.0 3.7 4 1 0 4 4 4 2 GRAM domain MIB_HERC2 PF06701.13 PIK48373.1 - 5.1e-49 164.4 27.4 2.4e-25 88.5 4.5 3.9 4 1 0 4 4 4 2 Mib_herc2 Ank_2 PF12796.7 PIK48373.1 - 1e-38 131.8 4.6 5.5e-13 49.3 0.0 5.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK48373.1 - 1.1e-36 124.7 6.8 3.4e-10 40.3 0.0 7.4 4 1 4 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK48373.1 - 4.6e-36 121.7 8.8 4.6e-07 30.0 0.2 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 PIK48373.1 - 6.3e-34 115.6 7.1 4e-10 39.8 0.1 7.1 2 1 6 8 8 8 6 Ankyrin repeats (many copies) SH3_15 PF18346.1 PIK48373.1 - 1.2e-31 108.8 18.3 3.8e-18 65.5 0.4 3.8 4 0 0 4 4 3 2 Mind bomb SH3 repeat domain Ank_3 PF13606.6 PIK48373.1 - 1.6e-26 89.4 1.5 0.00036 20.7 0.0 8.6 9 0 0 9 9 9 4 Ankyrin repeat zf-C3HC4_3 PF13920.6 PIK48373.1 - 1.3e-15 57.0 59.0 8.4e-09 35.2 8.4 4.7 4 0 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.17 PIK48373.1 - 3.4e-08 33.1 9.2 3.4e-08 33.1 9.2 4.0 4 1 1 5 5 4 1 Zinc finger, ZZ type NfeD PF01957.18 PIK48373.1 - 0.00068 20.0 1.6 0.39 11.1 0.1 3.0 1 1 2 3 3 3 2 NfeD-like C-terminal, partner-binding zf-RING_5 PF14634.6 PIK48373.1 - 4 7.5 57.9 0.3 11.1 1.4 4.9 4 0 0 4 4 4 0 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK48373.1 - 9.9 6.1 58.6 0.022 14.6 8.8 4.5 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 Asp_protease PF09668.10 PIK48374.1 - 2.1e-59 198.7 1.4 3.1e-59 198.2 1.4 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK48374.1 - 4.3e-26 91.3 0.0 9.3e-26 90.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK48374.1 - 3.3e-10 40.5 0.0 7.6e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 PIK48374.1 - 5.6e-06 26.2 0.1 1.1e-05 25.2 0.1 1.4 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 PIK48374.1 - 1.1e-05 25.7 0.1 2.3e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA PF00627.31 PIK48374.1 - 0.00073 19.4 0.1 0.0015 18.4 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain CHASE3 PF05227.13 PIK48374.1 - 0.13 12.2 4.0 0.25 11.2 4.0 1.5 1 0 0 1 1 1 0 CHASE3 domain Sas10 PF09368.10 PIK48375.1 - 4.3e-28 97.6 11.4 4.3e-28 97.6 11.4 3.4 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 PIK48375.1 - 2.3e-14 53.8 0.1 2.3e-14 53.8 0.1 3.9 5 1 0 5 5 5 1 Sas10/Utp3/C1D family Pex2_Pex12 PF04757.14 PIK48376.1 - 2.3e-34 119.0 10.0 3e-34 118.6 10.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 PIK48376.1 - 5.4e-11 42.2 8.8 7.8e-11 41.7 8.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48376.1 - 5.9e-09 36.1 13.3 9.3e-09 35.5 13.3 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 PIK48376.1 - 6.4e-07 29.1 9.1 1e-06 28.5 9.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 PIK48376.1 - 1e-06 28.5 11.6 1.5e-06 27.9 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK48376.1 - 2.6e-06 27.2 12.5 4.2e-06 26.5 12.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK48376.1 - 0.00013 21.9 9.5 0.00021 21.2 9.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 PIK48376.1 - 0.00014 22.0 8.5 0.00025 21.3 8.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK48376.1 - 0.0034 17.4 5.6 0.0034 17.4 5.6 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.6 PIK48376.1 - 0.13 12.2 5.6 0.24 11.3 5.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 PIK48376.1 - 0.24 11.6 11.8 1.3 9.3 12.2 2.0 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FancD2 PF14631.6 PIK48376.1 - 0.28 8.5 0.1 4.8 4.5 0.0 1.9 2 0 0 2 2 2 0 Fanconi anaemia protein FancD2 nuclease zf-RING_11 PF17123.5 PIK48376.1 - 0.5 10.2 3.7 3.5 7.5 1.3 2.5 2 1 0 2 2 2 0 RING-like zinc finger zf-RING_10 PF16685.5 PIK48376.1 - 1.5 9.0 7.7 2.6 8.2 7.7 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 PIK48376.1 - 1.7 8.5 10.8 3.1 7.7 10.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain MFS_1 PF07690.16 PIK48377.1 - 2.1e-10 40.0 6.7 1e-06 27.9 1.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 PIK48377.1 - 4.9e-10 38.5 12.3 2e-09 36.5 1.8 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein TED_complement PF07678.14 PIK48378.1 - 1.5e-32 112.9 0.0 2.1e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_recep PF07677.14 PIK48378.1 - 5.2e-21 75.2 0.0 8.6e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain SPX PF03105.19 PIK48378.1 - 0.0014 18.7 0.5 0.0016 18.4 0.5 1.1 1 0 0 1 1 1 1 SPX domain DUF2615 PF11027.8 PIK48378.1 - 0.034 14.3 0.5 0.089 12.9 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) CBP_BcsG PF11658.8 PIK48378.1 - 0.077 11.4 0.9 0.43 8.9 0.2 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Prenyltrans PF00432.21 PIK48378.1 - 0.12 12.1 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat DUF3328 PF11807.8 PIK48378.1 - 0.19 11.5 3.8 0.35 10.6 3.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF4834 PF16118.5 PIK48378.1 - 0.37 11.8 13.8 0.89 10.6 13.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 PIK48378.1 - 0.49 11.3 9.8 2.1 9.3 9.9 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Pex24p PF06398.11 PIK48378.1 - 0.88 8.5 6.0 1.4 7.8 6.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Herpes_LMP1 PF05297.11 PIK48378.1 - 5.1 6.2 13.2 8.1 5.5 13.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Kazal_2 PF07648.15 PIK48379.1 - 1.7e-91 300.2 126.4 2e-10 40.6 2.2 15.2 12 0 0 12 12 12 12 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK48379.1 - 8.9e-78 256.1 146.3 1.3e-08 34.7 4.3 14.4 9 2 5 14 14 14 12 Kazal-type serine protease inhibitor domain EGF PF00008.27 PIK48379.1 - 6.3e-75 247.0 454.9 1.5e-07 31.6 6.4 31.8 29 1 1 30 30 30 24 EGF-like domain SLD5_C PF16922.5 PIK48379.1 - 2e-08 34.3 12.4 3.9 7.7 0.0 7.0 7 0 0 7 7 7 4 DNA replication complex GINS protein SLD5 C-terminus HYR PF02494.16 PIK48379.1 - 1.9e-05 24.9 3.8 8.8e-05 22.8 0.2 3.2 3 0 0 3 3 3 1 HYR domain hEGF PF12661.7 PIK48379.1 - 0.00055 20.5 25.7 0.0009 19.8 9.5 37.9 38 1 1 39 39 39 14 Human growth factor-like EGF Paramyxo_C PF01692.18 PIK48379.1 - 1.3 8.3 9.6 81 2.5 0.1 5.0 3 2 3 6 6 6 0 Paramyxovirus non-structural protein C EGF PF00008.27 PIK48380.1 - 1.2e-21 76.6 74.8 9e-06 25.9 11.2 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_2 PF07974.13 PIK48380.1 - 1.6e-06 28.3 74.5 0.01 16.2 13.6 6.0 5 1 1 6 6 6 5 EGF-like domain DUF917 PF06032.12 PIK48380.1 - 0.16 10.8 0.0 0.63 8.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF917) hEGF PF12661.7 PIK48380.1 - 2.7 8.7 68.0 0.15 12.7 9.7 8.4 7 3 0 7 7 7 0 Human growth factor-like EGF Ig_2 PF13895.6 PIK48381.1 - 0.00032 21.0 0.0 0.00038 20.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK48381.1 - 0.0007 20.2 0.0 0.00075 20.1 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK48381.1 - 0.01 15.9 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain FMN_dh PF01070.18 PIK48382.1 - 2.2e-102 342.7 0.0 2.5e-102 342.5 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK48382.1 - 5.4e-10 38.8 0.1 8.4e-10 38.2 0.1 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK48382.1 - 9.7e-05 21.7 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK48382.1 - 0.0052 16.2 0.9 0.0052 16.2 0.9 1.5 2 0 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK48382.1 - 0.0069 15.9 0.2 0.032 13.7 0.1 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 PIK48382.1 - 0.019 14.3 0.5 2.5 7.3 0.2 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 PIK48382.1 - 0.081 12.3 0.1 5.2 6.4 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator RT_RNaseH_2 PF17919.1 PIK48383.1 - 2.4e-35 120.5 0.0 4e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48383.1 - 1.3e-27 96.1 0.0 2.4e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48383.1 - 0.016 14.7 0.1 0.028 13.9 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 PIK48384.1 - 1.7e-12 47.8 18.7 0.00045 20.8 0.5 7.0 5 1 1 6 6 6 4 Immunoglobulin domain C2-set_2 PF08205.12 PIK48384.1 - 7e-12 45.2 0.4 8.2e-05 22.6 0.0 3.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK48384.1 - 3.6e-07 30.3 17.5 0.1 12.8 0.9 6.2 6 1 0 6 6 6 3 Immunoglobulin domain I-set PF07679.16 PIK48384.1 - 4.4e-07 29.9 6.6 0.59 10.2 0.2 5.9 6 0 0 6 6 6 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK48384.1 - 9.5e-07 29.1 18.9 0.62 10.4 0.2 6.7 5 1 0 6 6 6 3 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK48384.1 - 1.7e-06 27.5 0.1 3.2e-05 23.4 0.1 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase V-set PF07686.17 PIK48384.1 - 2.7e-06 27.5 7.1 0.043 14.0 0.0 5.4 4 1 0 4 4 4 2 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK48384.1 - 0.00037 20.7 4.0 4.9 7.5 0.0 5.4 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK48384.1 - 0.0011 19.3 7.6 0.2 12.1 0.2 5.1 4 1 0 4 4 4 2 Immunoglobulin C1-set domain Pkinase PF00069.25 PIK48384.1 - 0.0019 17.6 0.0 0.0047 16.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ig_6 PF18452.1 PIK48384.1 - 0.0034 16.9 0.1 0.13 11.9 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK48384.1 - 0.019 15.0 0.1 7.1 6.8 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK48384.1 - 0.22 11.3 5.9 7.1 6.5 0.3 3.1 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Pkinase PF00069.25 PIK48385.1 - 8.7e-06 25.3 0.0 1.9e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase PF00069.25 PIK48386.1 - 4e-18 65.7 0.0 8e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48386.1 - 5.9e-13 48.7 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK48386.1 - 0.0012 17.7 0.1 0.0019 17.0 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK48386.1 - 0.2 11.5 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Aminotran_3 PF00202.21 PIK48387.1 - 1.1e-68 231.8 0.1 2.2e-50 171.5 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-III PP2C PF00481.21 PIK48388.1 - 3.8e-20 72.6 0.0 7.2e-19 68.4 0.0 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C zf-CCHC_6 PF15288.6 PIK48388.1 - 0.077 12.9 0.1 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Zinc knuckle BTHB PF18410.1 PIK48388.1 - 0.17 11.7 0.0 0.39 10.6 0.0 1.6 1 0 0 1 1 1 0 Basic tilted helix bundle domain TRIQK PF15168.6 PIK48390.1 - 3.2e-23 81.4 0.4 3.6e-23 81.2 0.4 1.0 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family Orf78 PF06024.12 PIK48390.1 - 0.00012 22.3 0.0 0.00014 22.1 0.0 1.2 1 0 0 1 1 1 1 Orf78 (ac78) Wbp11 PF09429.10 PIK48390.1 - 0.00068 20.0 1.7 0.0009 19.6 1.7 1.2 1 0 0 1 1 1 1 WW domain binding protein 11 MPS-4 PF17523.2 PIK48390.1 - 0.02 15.0 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 K1377 PF15352.6 PIK48390.1 - 0.075 11.3 0.1 0.087 11.1 0.1 1.0 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy TPX2_importin PF12214.8 PIK48391.1 - 1.2e-23 84.2 70.7 1.3e-11 45.0 0.2 8.1 5 3 2 7 7 7 5 Cell cycle regulated microtubule associated protein TPX2 PF06886.11 PIK48391.1 - 2.3e-12 47.0 12.0 2.3e-12 47.0 12.0 7.4 8 0 0 8 8 8 1 Targeting protein for Xklp2 (TPX2) Aurora-A_bind PF09041.10 PIK48391.1 - 0.006 16.6 4.8 0.023 14.8 4.8 2.0 1 0 0 1 1 1 1 Aurora-A binding DUF5406 PF17400.2 PIK48391.1 - 0.12 12.8 2.6 12 6.3 1.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5406) LRR_4 PF12799.7 PIK48392.1 - 3.3e-12 46.4 1.7 0.00066 20.0 0.0 3.6 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK48392.1 - 1.5e-10 40.6 1.9 3.1e-05 23.7 0.1 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 PIK48392.1 - 0.022 15.3 9.5 42 5.3 0.1 5.9 7 0 0 7 7 7 0 Leucine Rich Repeat XPG_N PF00752.17 PIK48393.1 - 2.5e-32 111.4 0.0 4.6e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 PIK48393.1 - 1.1e-28 99.4 0.0 2.9e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 PIK48393.1 - 1e-06 29.2 0.0 3.1e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 PIK48393.1 - 0.017 15.1 0.0 0.092 12.7 0.0 2.0 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain DEAD PF00270.29 PIK48394.1 - 2.7e-46 157.6 0.2 9.1e-46 155.8 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK48394.1 - 1.8e-27 95.8 0.1 3.1e-26 91.9 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 PIK48394.1 - 0.21 11.9 4.4 0.3 11.4 0.7 3.1 3 1 0 3 3 3 0 AAA domain RVT_1 PF00078.27 PIK48395.1 - 3.5e-26 92.1 0.0 5.6e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48395.1 - 1.1e-06 28.6 0.1 2.8e-06 27.3 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_thumb PF06817.14 PIK48395.1 - 0.023 14.6 0.0 0.063 13.1 0.0 1.8 1 0 0 1 1 1 0 Reverse transcriptase thumb domain DUF4466 PF14725.6 PIK48395.1 - 0.066 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4466) CRISPR_Cse2 PF09485.10 PIK48395.1 - 0.17 12.4 1.3 2 8.9 0.1 2.3 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DnaJ_CXXCXGXG PF00684.19 PIK48396.1 - 0.018 15.4 7.7 0.44 10.9 1.6 2.9 3 0 0 3 3 3 0 DnaJ central domain SelP_N PF04592.14 PIK48396.1 - 4 6.8 12.6 6.9 6.0 12.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PRP4 PF08799.11 PIK48397.1 - 3e-11 42.6 2.8 7.3e-11 41.4 2.8 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Prp18 PF02840.15 PIK48398.1 - 1.5e-39 135.3 0.0 1.6e-39 135.2 0.0 1.0 1 0 0 1 1 1 1 Prp18 domain DUF5371 PF17341.2 PIK48398.1 - 0.045 14.0 0.0 0.072 13.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5371) zf-RING_6 PF14835.6 PIK48399.1 - 1.6e-09 37.5 5.5 2.9e-07 30.3 5.4 2.7 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 PIK48399.1 - 6e-08 32.4 12.6 6e-08 32.4 12.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 PIK48399.1 - 2.8e-07 30.1 0.4 6.1e-07 29.0 0.4 1.6 1 0 0 1 1 1 1 SAP domain zf-C3HC4 PF00097.25 PIK48399.1 - 1.2e-05 25.1 15.0 1.2e-05 25.1 15.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK48399.1 - 1.3e-05 25.0 15.8 8.3e-05 22.4 11.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48399.1 - 1.7e-05 25.0 17.5 1.8e-05 25.0 12.4 2.6 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK48399.1 - 5.6e-05 23.0 17.7 7.1e-05 22.7 13.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK48399.1 - 0.00041 20.3 9.6 0.00041 20.3 9.6 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_10 PF16685.5 PIK48399.1 - 0.0021 18.1 10.6 0.0029 17.7 9.4 1.9 1 1 0 1 1 1 1 zinc RING finger of MSL2 RNF220 PF15926.5 PIK48399.1 - 0.0023 17.6 0.6 0.0023 17.6 0.6 3.4 4 0 0 4 4 4 1 E3 ubiquitin-protein ligase RNF220 zf-rbx1 PF12678.7 PIK48399.1 - 0.0051 17.1 8.9 0.0051 17.1 8.9 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK48399.1 - 0.42 10.7 5.4 0.45 10.6 2.4 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 PIK48399.1 - 0.69 9.8 14.1 5.3 7.0 9.8 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-WRNIP1_ubi PF18279.1 PIK48399.1 - 1.1 10.1 3.8 2.9 8.7 0.3 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C3HC4_4 PF15227.6 PIK48399.1 - 3.3 8.0 19.3 0.66 10.2 14.7 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Ig_3 PF13927.6 PIK48400.1 - 1.7e-06 28.5 5.6 3.5 8.3 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK48400.1 - 6.7e-06 26.1 2.4 0.038 14.0 0.8 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK48400.1 - 6e-05 23.2 0.1 0.00071 19.7 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain ERAP1_C PF11838.8 PIK48400.1 - 0.027 14.0 0.2 3.1 7.2 0.0 2.9 2 0 0 2 2 2 0 ERAP1-like C-terminal domain PBS_linker_poly PF00427.21 PIK48400.1 - 0.05 13.6 9.5 0.22 11.6 0.1 5.5 5 0 0 5 5 5 0 Phycobilisome Linker polypeptide EF-hand_6 PF13405.6 PIK48400.1 - 0.088 12.8 1.5 45 4.3 0.1 4.6 3 0 0 3 3 3 0 EF-hand domain CUT PF02376.15 PIK48400.1 - 0.15 12.2 9.1 38 4.5 0.0 6.9 8 0 0 8 8 8 0 CUT domain FeoB_associated PF12669.7 PIK48400.1 - 0.15 12.5 2.7 0.42 11.1 2.7 1.7 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein RHH_4 PF13467.6 PIK48400.1 - 0.16 11.9 2.7 3.7 7.5 0.0 4.8 5 0 0 5 5 5 0 Ribbon-helix-helix domain EF-hand_8 PF13833.6 PIK48400.1 - 0.28 11.1 5.3 36 4.3 0.1 6.1 5 2 1 6 6 5 0 EF-hand domain pair Syndecan PF01034.20 PIK48400.1 - 0.6 10.1 2.6 1.5 8.8 2.6 1.6 1 0 0 1 1 1 0 Syndecan domain RST PF12174.8 PIK48400.1 - 1.7 8.6 32.0 1.6 8.7 0.1 10.3 9 3 1 11 11 11 0 RCD1-SRO-TAF4 (RST) plant domain FCH PF00611.23 PIK48400.1 - 5.2 7.4 17.8 8.7 6.7 1.3 5.5 4 1 1 5 5 4 0 Fes/CIP4, and EFC/F-BAR homology domain SHOCT PF09851.9 PIK48400.1 - 9.8 6.1 6.9 20 5.1 0.0 4.7 5 0 0 5 5 4 0 Short C-terminal domain Pkinase_Tyr PF07714.17 PIK48401.1 - 1.4e-29 103.2 0.0 1.7e-29 102.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48401.1 - 3.1e-11 43.1 0.0 4e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48402.1 - 4e-28 98.4 0.0 7.6e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48402.1 - 4.7e-13 49.1 0.0 9.4e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK48402.1 - 1.3e-05 25.6 1.0 3.7e-05 24.2 0.4 2.0 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK48402.1 - 2.4e-05 24.3 0.1 5.6e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 PIK48402.1 - 0.00063 19.9 1.1 0.0024 18.0 1.1 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK48402.1 - 0.0044 17.3 0.7 0.012 16.0 0.7 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK48402.1 - 0.064 13.4 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin domain DUF4770 PF15994.5 PIK48402.1 - 0.14 12.4 0.5 0.25 11.6 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Pkinase_Tyr PF07714.17 PIK48403.1 - 1.9e-20 73.2 0.0 1.5e-10 40.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK48403.1 - 7.9e-09 35.3 0.0 0.0038 16.6 0.0 2.6 2 1 1 3 3 3 2 Protein kinase domain DUF1713 PF08213.11 PIK48404.1 - 0.00088 19.1 22.7 0.00088 19.1 22.7 1.8 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) AGTRAP PF06396.11 PIK48405.1 - 9.8e-27 93.6 0.0 1.2e-26 93.3 0.0 1.0 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) LRR_4 PF12799.7 PIK48406.1 - 1.3e-23 82.7 13.8 4.2e-08 33.3 1.0 4.2 4 0 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK48406.1 - 1.6e-19 70.1 4.4 1.5e-16 60.4 1.9 2.4 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 PIK48406.1 - 1.7e-18 66.1 35.2 1.7e-09 37.3 2.1 4.0 1 1 4 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 PIK48406.1 - 3.1e-15 54.9 15.3 0.018 15.1 0.1 6.4 5 1 1 6 6 6 5 Leucine Rich repeat LRR_1 PF00560.33 PIK48406.1 - 9.4e-05 22.5 15.9 1.7 9.5 0.2 6.5 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_3 PF07725.12 PIK48406.1 - 0.019 14.8 3.4 0.27 11.1 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat Acetyltransf_11 PF13720.6 PIK48407.1 - 0.029 14.8 0.0 0.091 13.2 0.0 1.8 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SAS-6_N PF16531.5 PIK48408.1 - 7.8e-25 87.3 1.8 7.8e-25 87.3 1.8 2.3 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal Sas6_CC PF18594.1 PIK48408.1 - 1.9e-07 30.7 0.6 1.9e-07 30.7 0.6 4.1 3 0 0 3 3 3 1 Sas6/XLF/XRCC4 coiled-coil domain DUF1043 PF06295.12 PIK48408.1 - 0.012 15.6 6.5 0.012 15.6 6.5 4.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) AalphaY_MDB PF04611.12 PIK48408.1 - 0.034 14.2 0.4 0.034 14.2 0.4 2.9 3 1 1 4 4 4 0 Mating type protein A alpha Y mating type dependent binding region Spc7 PF08317.11 PIK48408.1 - 3.6 6.4 77.2 4.2 6.2 23.4 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein Pro_isomerase PF00160.21 PIK48409.1 - 2.2e-26 93.0 0.0 4.9e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 PIK48409.1 - 3.3e-08 34.1 0.3 0.24 12.3 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48409.1 - 0.13 12.6 0.0 1.9 8.8 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RNF220 PF15926.5 PIK48410.1 - 2.5e-38 132.1 11.4 7.1e-37 127.4 11.4 2.0 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 DNA_ligase_ZBD PF03119.16 PIK48410.1 - 0.0045 17.0 2.0 2.2 8.4 0.2 3.1 3 0 0 3 3 3 2 NAD-dependent DNA ligase C4 zinc finger domain zf-Mss51 PF13824.6 PIK48410.1 - 0.0046 17.0 2.7 0.19 11.8 0.4 2.5 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2_9 PF16293.5 PIK48410.1 - 0.019 14.8 0.4 5.8 6.8 0.1 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) CTU2 PF10288.9 PIK48410.1 - 0.025 14.8 9.6 0.64 10.3 1.4 2.3 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 PRP21_like_P PF12230.8 PIK48410.1 - 0.042 13.7 2.9 0.51 10.2 0.8 2.2 1 1 1 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein zf-RING_6 PF14835.6 PIK48410.1 - 0.051 13.5 0.5 0.19 11.6 0.2 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Rad50_zn_hook PF04423.14 PIK48410.1 - 0.065 13.1 5.3 2.3 8.1 0.4 2.9 3 0 0 3 3 2 0 Rad50 zinc hook motif Spore_YhaL PF14147.6 PIK48410.1 - 0.085 12.6 1.1 0.25 11.1 0.0 2.3 3 0 0 3 3 3 0 Sporulation protein YhaL zf-C2H2_4 PF13894.6 PIK48410.1 - 0.1 13.5 1.1 10 7.3 0.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 PIK48410.1 - 0.22 11.8 3.8 2.2 8.6 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3 PF13878.6 PIK48410.1 - 0.32 10.9 3.5 12 5.8 0.1 2.6 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO YhfH PF14149.6 PIK48410.1 - 0.37 10.8 2.9 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 YhfH-like protein Zn-ribbon_8 PF09723.10 PIK48410.1 - 0.5 10.5 5.3 4.6 7.4 0.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DUF3797 PF12677.7 PIK48410.1 - 0.5 10.3 3.0 14 5.6 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3797) Zn-C2H2_12 PF18112.1 PIK48410.1 - 5.5 7.5 9.7 23 5.6 2.7 3.2 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C3HC4_2 PF13923.6 PIK48411.1 - 4.3e-15 55.3 8.5 8.3e-15 54.4 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK48411.1 - 2e-07 30.7 7.5 3.1e-07 30.1 7.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK48411.1 - 2.2e-07 30.7 6.0 3.8e-07 30.0 6.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 PIK48411.1 - 1.3e-06 28.6 8.3 1.3e-06 28.6 8.3 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 PIK48411.1 - 3.5e-06 26.8 6.8 6.4e-06 25.9 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK48411.1 - 1.4e-05 25.1 4.0 1.4e-05 25.1 4.0 1.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_6 PF14835.6 PIK48411.1 - 6.2e-05 22.8 1.5 9.7e-05 22.2 1.5 1.2 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 PIK48411.1 - 6.7e-05 22.6 1.3 0.0001 22.0 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 PIK48411.1 - 7.1e-05 22.6 5.6 0.00012 21.8 5.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK48411.1 - 0.00071 19.7 8.1 0.0018 18.4 8.1 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 PIK48411.1 - 0.023 14.8 6.7 0.033 14.3 6.7 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 PIK48411.1 - 0.029 14.7 6.1 0.05 13.9 6.1 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 PIK48411.1 - 0.048 13.5 9.7 0.082 12.7 8.6 1.9 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Ran-binding PF05508.11 PIK48411.1 - 0.13 11.2 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 RanGTP-binding protein zf-C3H2C3 PF17122.5 PIK48411.1 - 0.64 10.1 9.2 0.56 10.3 7.4 1.9 2 1 0 2 2 2 0 Zinc-finger FYDLN_acid PF09538.10 PIK48411.1 - 4.4 8.0 4.6 9.2 7.0 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) Y_phosphatase PF00102.27 PIK48412.1 - 2.9e-120 400.1 9.6 3.4e-76 255.9 3.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK48412.1 - 7.4e-11 42.0 2.2 0.00013 21.8 0.2 2.9 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK48412.1 - 0.0019 18.2 0.2 0.0052 16.8 0.1 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family TMEM51 PF15345.6 PIK48412.1 - 0.049 13.5 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Shisa PF13908.6 PIK48412.1 - 0.049 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Y_phosphatase PF00102.27 PIK48413.1 - 1.8e-110 368.1 5.5 5.6e-68 229.0 1.2 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK48413.1 - 2.3e-11 43.6 1.5 4.6e-06 26.5 0.1 2.7 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK48413.1 - 0.00012 22.2 0.1 0.48 10.5 0.0 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK48413.1 - 0.00057 19.9 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family hEGF PF12661.7 PIK48414.1 - 0.0022 18.6 10.4 0.0022 18.6 10.4 6.3 7 1 0 7 7 7 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK48414.1 - 3 8.3 60.5 0.057 13.8 11.8 6.9 5 2 2 7 7 7 0 EGF-like domain Ig_3 PF13927.6 PIK48415.1 - 0.00077 20.0 0.3 0.003 18.1 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK48415.1 - 0.0095 16.0 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain EGF PF00008.27 PIK48415.1 - 2 8.8 19.5 7.6 6.9 1.8 4.6 4 0 0 4 4 4 0 EGF-like domain Y_phosphatase PF00102.27 PIK48416.1 - 5.5e-26 91.6 0.6 1.7e-16 60.5 0.0 2.3 1 1 1 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK48416.1 - 8.1e-05 22.9 1.5 0.00014 22.2 0.6 1.8 2 0 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 PIK48416.1 - 0.029 14.7 0.3 0.071 13.4 0.3 1.6 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III RINGv PF12906.7 PIK48416.1 - 0.12 12.5 0.8 21 5.3 0.0 2.9 3 0 0 3 3 3 0 RING-variant domain DUF615 PF04751.14 PIK48416.1 - 0.2 11.6 1.3 1.3 9.0 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF615) Y_Y_Y PF07495.13 PIK48416.1 - 0.53 10.3 3.3 1.4 8.9 2.3 2.2 2 0 0 2 2 2 0 Y_Y_Y domain fn3 PF00041.21 PIK48417.1 - 3e-07 30.7 0.5 5.6e-07 29.8 0.5 1.4 1 0 0 1 1 1 1 Fibronectin type III domain DUF2369 PF10179.9 PIK48417.1 - 0.013 15.9 0.1 0.024 15.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Ig_3 PF13927.6 PIK48418.1 - 7.3e-08 32.9 0.0 2.3e-06 28.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK48418.1 - 5.5e-05 23.3 0.1 0.015 15.4 0.0 2.8 1 1 1 2 2 2 1 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK48418.1 - 0.00018 21.8 0.0 0.0006 20.2 0.0 1.7 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK48418.1 - 0.00076 19.5 0.0 0.0034 17.4 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_4 PF16680.5 PIK48418.1 - 0.0055 16.9 0.0 0.016 15.5 0.0 1.7 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain ig PF00047.25 PIK48418.1 - 0.044 14.0 0.1 0.21 11.8 0.0 2.2 3 0 0 3 3 3 0 Immunoglobulin domain Y_phosphatase PF00102.27 PIK48419.1 - 2.9e-119 396.9 5.6 3.1e-75 252.8 0.6 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK48419.1 - 1.9e-10 40.7 1.4 0.00087 19.1 0.0 3.1 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK48419.1 - 2.1e-05 24.8 1.5 6.1e-05 23.3 1.5 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Y_phosphatase3 PF13350.6 PIK48419.1 - 0.00037 20.5 0.0 0.0027 17.7 0.0 2.1 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK48419.1 - 0.0016 18.6 0.0 0.026 14.7 0.0 2.4 2 0 0 2 2 2 1 Inositol hexakisphosphate Thioredoxin_13 PF18401.1 PIK48419.1 - 0.012 15.5 0.0 0.081 12.8 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Interfer-bind PF09294.10 PIK48419.1 - 0.031 14.6 1.2 0.081 13.3 1.2 1.7 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Y_phosphatase2 PF03162.13 PIK48419.1 - 0.033 13.8 0.0 0.099 12.2 0.0 1.8 1 0 0 1 1 1 0 Tyrosine phosphatase family fn3 PF00041.21 PIK48420.1 - 7.3e-09 35.9 4.2 2.2e-05 24.7 0.4 2.3 2 0 0 2 2 2 2 Fibronectin type III domain SusE PF14292.6 PIK48420.1 - 0.0046 17.2 0.9 0.038 14.2 0.1 2.4 2 0 0 2 2 2 1 SusE outer membrane protein Ig_3 PF13927.6 PIK48421.1 - 3.6e-08 33.9 0.0 2.5e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK48421.1 - 3.4e-06 27.4 0.0 1.1e-05 25.7 0.0 1.7 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 PIK48421.1 - 7e-05 23.0 0.3 0.025 14.8 0.0 2.9 1 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK48421.1 - 0.00041 20.5 0.1 0.0017 18.6 0.0 1.9 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK48421.1 - 0.00085 19.3 0.0 0.0051 16.9 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK48421.1 - 0.027 14.6 0.0 0.088 13.0 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 PIK48421.1 - 0.094 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain CLP_protease PF00574.23 PIK48422.1 - 2e-66 223.4 0.0 2.3e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 Clp protease LRR_8 PF13855.6 PIK48423.1 - 1.4e-36 124.1 34.2 1.3e-11 44.1 3.8 6.0 5 1 2 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 PIK48423.1 - 3.8e-34 116.1 40.5 3.3e-07 30.5 0.3 7.7 4 2 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK48423.1 - 1.4e-10 40.2 31.0 1.4 9.8 0.8 10.5 11 1 0 11 11 11 5 Leucine Rich Repeat LRR_9 PF14580.6 PIK48423.1 - 2.2e-09 37.1 16.4 0.00024 20.7 2.6 4.3 2 2 2 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 PIK48423.1 - 9.8e-05 22.1 38.9 3.6 7.9 0.1 10.9 12 0 0 12 12 12 3 Leucine Rich repeat CREPT PF16566.5 PIK48423.1 - 0.06 13.5 0.8 11 6.1 0.0 4.1 4 1 1 5 5 5 0 Cell-cycle alteration and expression-elevated protein in tumour EamA PF00892.20 PIK48424.1 - 2.6e-13 50.3 5.2 2.1e-12 47.4 1.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK48424.1 - 0.011 15.1 1.6 0.011 15.1 1.6 1.4 1 1 0 1 1 1 0 Triose-phosphate Transporter family Exo_endo_phos PF03372.23 PIK48425.1 - 1e-09 38.2 0.1 1.5e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 PIK48426.1 - 4.5e-07 29.6 0.0 6.7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sec16_C PF12931.7 PIK48426.1 - 0.078 12.6 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 Exo_endo_phos PF03372.23 PIK48429.1 - 8.2e-16 58.2 0.1 1.2e-07 31.5 0.0 2.6 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family M157 PF11624.8 PIK48429.1 - 0.15 11.4 0.0 9.8 5.4 0.0 2.6 3 0 0 3 3 3 0 MHC class I-like protein M157 Exo_endo_phos PF03372.23 PIK48430.1 - 3.8e-12 46.2 0.0 8e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Dynein_IC2 PF11540.8 PIK48430.1 - 0.27 11.2 1.8 13 5.8 0.2 2.7 2 0 0 2 2 2 0 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.32 PIK48431.1 - 8.3e-34 115.1 30.8 5e-06 27.1 0.4 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 PIK48431.1 - 9.9e-12 44.6 0.6 5e-11 42.3 0.2 2.3 2 0 0 2 2 2 1 F-box-like WD40_like PF17005.5 PIK48431.1 - 1e-10 41.4 2.3 8.8e-05 22.0 0.5 2.1 1 1 1 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 PIK48431.1 - 1.4e-08 34.9 4.0 0.0048 17.2 0.0 5.5 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 PIK48431.1 - 2.5e-07 30.4 0.9 9e-07 28.6 0.2 2.1 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 PIK48431.1 - 1.7e-05 23.7 3.0 0.071 11.7 0.0 3.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 PIK48431.1 - 2.8e-05 23.2 7.0 0.48 9.3 0.1 4.1 3 1 1 4 4 4 3 Partner and localizer of BRCA2 WD40 domain EF-hand_7 PF13499.6 PIK48432.1 - 3.7e-06 27.3 1.9 3.7e-06 27.3 1.9 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK48432.1 - 1.1e-05 25.0 1.4 0.02 14.8 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK48432.1 - 0.0001 21.6 0.7 0.022 14.3 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 PIK48432.1 - 0.025 14.9 3.2 0.13 12.6 3.2 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 PIK48432.1 - 0.047 13.2 0.5 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 EF hand zf-HC5HC2H PF13771.6 PIK48433.1 - 8.3e-15 54.8 2.3 8.3e-15 54.8 2.3 3.0 3 0 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 PIK48433.1 - 1.2e-05 25.4 0.8 1.2e-05 25.4 0.8 3.1 4 0 0 4 4 4 1 PHD-zinc-finger like domain Torus PF16131.5 PIK48433.1 - 0.06 14.1 0.9 0.47 11.2 0.0 3.0 2 0 0 2 2 2 0 Torus domain GST_N_3 PF13417.6 PIK48434.1 - 3.8e-09 36.8 0.0 6.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 PIK48434.1 - 2.3e-07 31.1 0.0 4e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK48434.1 - 7.4e-07 29.3 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK48434.1 - 1.8e-05 25.0 0.0 3.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK48434.1 - 0.00053 20.1 0.0 0.00099 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK48434.1 - 0.0018 18.2 0.0 0.0052 16.8 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain 7tm_1 PF00001.21 PIK48435.1 - 9.9e-23 80.8 6.3 1.3e-22 80.4 6.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK48435.1 - 7.8e-05 22.2 5.9 0.00011 21.7 5.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK48435.1 - 0.021 14.5 12.7 0.15 11.7 12.6 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF4126 PF13548.6 PIK48435.1 - 0.15 11.7 6.8 1.1 9.0 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4126) Tetraspanin PF00335.20 PIK48435.1 - 2.9 7.5 7.9 0.16 11.6 3.0 1.5 2 0 0 2 2 2 0 Tetraspanin family DUF2207 PF09972.9 PIK48435.1 - 3.2 6.4 10.7 1.6 7.4 3.1 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Methyltransf_11 PF08241.12 PIK48436.1 - 5e-19 68.7 0.0 1.2e-18 67.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK48436.1 - 1.7e-16 60.7 0.1 5.7e-16 59.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK48436.1 - 1.7e-15 57.1 0.0 2.4e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK48436.1 - 5.6e-11 43.1 0.0 1e-10 42.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK48436.1 - 1.5e-07 31.4 0.0 1.9e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK48436.1 - 6.9e-05 22.3 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 PIK48436.1 - 0.00065 19.3 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 PIK48436.1 - 0.00072 19.5 0.0 0.0029 17.5 0.0 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase TPMT PF05724.11 PIK48436.1 - 0.001 18.8 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_29 PF03141.16 PIK48436.1 - 0.0011 17.6 0.0 0.0016 17.1 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF938 PF06080.12 PIK48436.1 - 0.0017 18.1 0.0 0.0041 16.9 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_15 PF09445.10 PIK48436.1 - 0.0093 15.6 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase DUF2315 PF10231.9 PIK48436.1 - 0.018 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Apoptogenic protein 1 PrmA PF06325.13 PIK48436.1 - 0.018 14.4 0.0 0.044 13.2 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 PIK48436.1 - 0.056 12.7 0.0 0.1 11.9 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 PIK48436.1 - 0.056 12.9 0.0 0.096 12.1 0.0 1.5 1 1 0 1 1 1 0 Putative methyltransferase MetW PF07021.12 PIK48436.1 - 0.059 13.0 0.0 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TehB PF03848.14 PIK48436.1 - 0.068 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB HxlR PF01638.17 PIK48436.1 - 0.1 12.4 0.2 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 HxlR-like helix-turn-helix PCMT PF01135.19 PIK48436.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 7tm_1 PF00001.21 PIK48437.1 - 9.3e-23 80.9 2.8 1.1e-22 80.6 2.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK48437.1 - 0.00014 21.3 3.3 0.00019 20.9 3.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Tmemb_9 PF05434.11 PIK48437.1 - 0.026 14.4 3.7 1.6 8.6 0.0 3.0 3 0 0 3 3 3 0 TMEM9 Tetraspanin PF00335.20 PIK48437.1 - 0.077 12.7 3.8 0.024 14.4 0.8 1.7 2 0 0 2 2 2 0 Tetraspanin family DUF4126 PF13548.6 PIK48437.1 - 0.09 12.5 5.4 1.6 8.4 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4126) DUF2207 PF09972.9 PIK48437.1 - 0.35 9.6 8.5 2 7.1 2.6 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) FbpA PF05833.11 PIK48438.1 - 1.1e-40 139.8 8.4 1.1e-40 139.8 8.4 2.6 3 0 0 3 3 3 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 PIK48438.1 - 7e-34 116.8 3.1 1.1e-33 116.1 0.0 2.9 3 0 0 3 3 3 1 NFACT protein RNA binding domain TGF_beta PF00019.20 PIK48439.1 - 4.8e-20 72.5 2.1 8.3e-20 71.7 2.1 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain DAN PF03045.15 PIK48439.1 - 0.0011 19.0 1.2 0.0018 18.3 1.2 1.5 1 0 0 1 1 1 1 DAN domain DUF4619 PF15398.6 PIK48440.1 - 1.2e-08 34.8 1.2 1.2e-08 34.8 1.2 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4619) PIN_4 PF13638.6 PIK48440.1 - 1.1 9.6 7.6 0.46 10.8 1.2 2.3 2 1 0 2 2 2 0 PIN domain Kelch_4 PF13418.6 PIK48441.1 - 1.2e-39 134.1 5.9 2.4e-08 33.9 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK48441.1 - 5.4e-34 115.8 5.2 2.3e-06 27.7 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK48441.1 - 7.3e-28 96.1 2.6 0.00015 21.6 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 PIK48441.1 - 2e-26 91.3 4.2 1.2e-05 24.8 0.0 5.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 PIK48441.1 - 2.1e-23 81.7 6.9 8.7e-05 22.7 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 PIK48441.1 - 2e-18 65.6 11.3 0.00041 20.2 0.1 6.0 6 0 0 6 6 6 5 Kelch motif DUF4392 PF14336.6 PIK48442.1 - 1.5e-86 290.5 0.0 2e-86 290.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.12 PIK48442.1 - 1e-42 145.5 0.0 1.8e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) RVT_1 PF00078.27 PIK48443.1 - 6.6e-06 25.8 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK48444.1 - 5.9e-22 77.5 0.1 1.5e-21 76.2 0.1 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK48444.1 - 3e-17 62.5 0.0 6.1e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48444.1 - 2e-15 57.0 0.0 5.3e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK48444.1 - 8.5e-06 26.0 0.0 3.5e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK48444.1 - 5.4e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DUF2746 PF10874.8 PIK48445.1 - 0.0022 18.4 0.0 0.0046 17.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2746) PIG-H PF10181.9 PIK48446.1 - 3.6e-18 65.2 0.2 5.7e-18 64.5 0.2 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component UPF0564 PF10595.9 PIK48447.1 - 6.6e-67 226.1 57.6 1.4e-66 225.0 57.6 1.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 PRAP PF15314.6 PIK48447.1 - 0.02 15.4 1.5 0.12 12.9 0.1 3.1 2 0 0 2 2 2 0 Proline-rich acidic protein 1, pregnancy-specific uterine DUF2852 PF11014.8 PIK48447.1 - 1.5 8.9 10.5 3.3 7.9 0.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) Cpn60_TCP1 PF00118.24 PIK48448.1 - 3.9e-152 507.3 14.6 4.7e-152 507.1 14.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Peptidase_C2 PF00648.21 PIK48449.1 - 3.7e-127 423.4 0.1 5.6e-127 422.8 0.1 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 PIK48449.1 - 4.3e-47 159.9 0.0 7.9e-47 159.1 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.6 PIK48449.1 - 1.6e-14 53.4 0.9 9e-09 35.1 0.2 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK48449.1 - 2.3e-13 48.7 0.6 1.6e-05 24.1 0.0 3.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK48449.1 - 4e-13 48.1 2.8 2.9e-06 26.8 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 PIK48449.1 - 1e-07 32.3 1.4 0.017 15.6 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK48449.1 - 0.00029 20.2 1.2 0.16 11.5 0.0 2.8 2 0 0 2 2 2 2 EF hand CENP-B_dimeris PF09026.10 PIK48449.1 - 0.081 13.3 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SOUL PF04832.12 PIK48450.1 - 1.4e-26 93.6 5.0 2.3e-12 47.4 1.9 3.0 2 1 0 2 2 2 2 SOUL heme-binding protein Kelch_6 PF13964.6 PIK48450.1 - 0.05 13.9 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Kelch motif SOUL PF04832.12 PIK48451.1 - 3.2e-39 134.8 0.1 3.7e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein FYVE PF01363.21 PIK48452.1 - 3.3e-24 84.8 22.5 2.1e-14 53.4 9.0 3.7 3 1 0 3 3 3 2 FYVE zinc finger GBP PF02263.19 PIK48452.1 - 1.2e-05 24.7 0.1 1.8e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AIG1 PF04548.16 PIK48452.1 - 0.00076 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK48452.1 - 0.0012 18.9 0.0 0.0029 17.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FYVE_2 PF02318.16 PIK48452.1 - 0.031 14.5 1.1 0.031 14.5 1.1 3.6 3 0 0 3 3 3 0 FYVE-type zinc finger WD40 PF00400.32 PIK48453.1 - 6.1e-07 30.0 1.8 7.4e-05 23.4 0.0 3.5 4 0 0 4 4 4 1 WD domain, G-beta repeat Nup160 PF11715.8 PIK48453.1 - 0.00025 19.8 0.1 0.22 10.1 0.1 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 PIK48453.1 - 0.13 12.6 0.0 0.91 9.9 0.0 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Sas10_Utp3 PF04000.15 PIK48454.1 - 0.072 13.7 0.1 0.12 13.0 0.0 1.5 1 1 1 2 2 2 0 Sas10/Utp3/C1D family Bestrophin PF01062.21 PIK48456.1 - 1.5e-101 339.7 2.3 1.9e-101 339.4 2.3 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel RT_RNaseH_2 PF17919.1 PIK48458.1 - 7.7e-27 93.3 0.0 2e-26 91.9 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48458.1 - 4.6e-21 75.1 0.0 1.1e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48458.1 - 6.3e-16 58.6 0.0 1.1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK48458.1 - 0.0025 17.4 0.0 0.0081 15.7 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 PIK48459.1 - 1.6e-16 60.4 2.6 0.00012 22.7 0.2 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48459.1 - 0.00055 20.2 0.0 0.44 10.9 0.2 3.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK48459.1 - 0.028 14.3 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK48459.1 - 0.069 11.8 0.1 0.096 11.3 0.1 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 TMCO5 PF14992.6 PIK48460.1 - 0.0011 18.6 16.7 0.0022 17.6 16.7 1.4 1 0 0 1 1 1 1 TMCO5 family Spc7 PF08317.11 PIK48460.1 - 0.0045 15.9 12.8 0.0072 15.2 12.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BRCA-2_OB3 PF09104.10 PIK48460.1 - 0.056 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 Atg14 PF10186.9 PIK48460.1 - 0.078 12.0 9.8 0.16 11.1 9.8 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 PIK48460.1 - 0.12 12.5 15.0 0.25 11.4 15.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tropomyosin_1 PF12718.7 PIK48460.1 - 2.3 8.4 20.4 13 6.0 2.5 2.7 1 1 1 2 2 2 0 Tropomyosin like DUF4140 PF13600.6 PIK48460.1 - 9.8 6.7 7.6 22 5.5 0.9 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Neurexophilin PF06312.12 PIK48462.1 - 4.5e-09 36.1 0.0 8.4e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 PIK48462.1 - 4.8e-07 30.5 0.0 1.1e-06 29.4 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Invasin_D3 PF09134.10 PIK48462.1 - 0.00037 20.8 0.4 0.0006 20.1 0.4 1.3 1 0 0 1 1 1 1 Invasin, domain 3 Fibrinogen_C PF00147.18 PIK48463.1 - 5.8e-57 193.0 8.1 6.4e-57 192.9 8.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Y_Y_Y PF07495.13 PIK48463.1 - 0.064 13.2 1.8 0.92 9.5 0.1 2.5 2 0 0 2 2 2 0 Y_Y_Y domain Fibrinogen_C PF00147.18 PIK48464.1 - 3.9e-61 206.7 5.6 5.4e-61 206.2 5.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK48464.1 - 0.00061 19.9 10.5 0.00061 19.9 10.5 2.8 2 0 0 2 2 2 1 EGF domain cEGF PF12662.7 PIK48464.1 - 0.068 13.1 7.3 0.22 11.5 3.2 3.1 3 0 0 3 3 3 0 Complement Clr-like EGF-like TIL PF01826.17 PIK48464.1 - 3 8.1 9.9 30 4.9 10.3 2.2 1 1 1 2 2 2 0 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK48464.1 - 4.5 7.4 14.3 0.19 11.8 7.7 2.2 2 0 0 2 2 2 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK48464.1 - 8.5 6.9 10.2 33 5.0 10.3 2.1 1 1 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK48465.1 - 7.7e-75 251.5 19.4 3e-67 226.7 13.0 2.7 2 1 1 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK48465.1 - 0.0026 17.1 4.8 0.055 12.8 0.4 2.2 1 1 0 2 2 2 2 Fibrillar collagen C-terminal domain Phosphodiest PF01663.22 PIK48466.1 - 5.8e-57 193.9 1.0 7.7e-57 193.5 1.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK48466.1 - 5.9e-05 22.6 0.5 0.008 15.6 0.2 2.5 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 PIK48466.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 PIK48466.1 - 0.00028 21.0 0.1 0.0088 16.1 0.1 2.2 2 0 0 2 2 2 1 PglZ domain DUF229 PF02995.17 PIK48466.1 - 0.015 13.9 0.0 0.023 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF229) OTCace_N PF02729.21 PIK48467.1 - 1.5e-44 151.6 0.0 3.1e-44 150.6 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 PIK48467.1 - 5.5e-41 139.7 0.1 1.2e-40 138.7 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 PIK48467.1 - 8e-33 113.7 0.0 2.5e-32 112.1 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain CPSase_L_D2 PF02786.17 PIK48467.1 - 1.7e-24 86.5 0.0 2.9e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Amidohydro_1 PF01979.20 PIK48467.1 - 5.3e-10 39.1 0.0 1.2e-08 34.7 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase family ATP-grasp PF02222.22 PIK48467.1 - 4.9e-09 36.0 0.0 9.7e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 PIK48467.1 - 6.9e-07 29.1 0.0 1.7e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 PIK48467.1 - 7e-07 29.0 0.0 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus MGS PF02142.22 PIK48467.1 - 1.1e-05 25.5 0.0 3.7e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain PDDEXK_10 PF07788.11 PIK48467.1 - 0.44 10.5 3.9 1.7 8.6 0.6 3.0 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily CPSase_L_D2 PF02786.17 PIK48468.1 - 1.7e-83 279.3 0.0 2.5e-83 278.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 PIK48468.1 - 3.7e-43 147.5 0.1 1.9e-39 135.4 0.2 2.3 2 0 0 2 2 2 2 Glutamine amidotransferase class-I Dala_Dala_lig_C PF07478.13 PIK48468.1 - 2.2e-07 30.6 0.1 5.7e-07 29.3 0.1 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 PIK48468.1 - 1e-05 25.2 0.1 1.7e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain Peptidase_C26 PF07722.13 PIK48468.1 - 3.4e-05 23.7 0.1 0.0039 17.0 0.1 2.6 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 PIK48468.1 - 0.0058 16.4 0.0 0.73 9.6 0.0 2.6 2 0 0 2 2 2 1 DJ-1/PfpI family ATP-grasp_3 PF02655.14 PIK48468.1 - 0.15 12.1 0.2 0.53 10.3 0.1 2.0 2 0 0 2 2 2 0 ATP-grasp domain PC-Esterase PF13839.6 PIK48468.1 - 0.17 11.6 0.1 0.29 10.8 0.1 1.3 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p ATP-grasp_5 PF13549.6 PIK48468.1 - 0.17 11.3 0.1 0.33 10.4 0.1 1.4 1 0 0 1 1 1 0 ATP-grasp domain Atrophin-1 PF03154.15 PIK48468.1 - 3.9 5.6 9.8 5.3 5.2 9.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family CPSase_sm_chain PF00988.22 PIK48469.1 - 4.3e-36 123.6 0.0 5e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain ATG11 PF10377.9 PIK48470.1 - 7.6e-21 74.5 0.2 7.6e-21 74.5 0.2 3.1 2 0 0 2 2 2 1 Autophagy-related protein 11 PKcGMP_CC PF16808.5 PIK48470.1 - 0.0073 16.1 4.8 0.0073 16.1 4.8 6.9 7 0 0 7 7 7 2 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran PF00005.27 PIK48472.1 - 4.3e-24 85.6 0.1 9.1e-24 84.5 0.1 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK48472.1 - 3.6e-22 78.9 20.1 6.8e-22 78.0 20.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 PIK48472.1 - 4.2e-14 53.1 0.0 2.4e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 PIK48472.1 - 0.018 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK48472.1 - 0.054 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 PIK48472.1 - 0.059 13.1 1.6 0.078 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 PIK48472.1 - 0.077 13.5 0.1 0.077 13.5 0.1 1.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 PIK48472.1 - 0.1 12.0 0.1 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC2_membrane PF01061.24 PIK48472.1 - 7.3 5.9 31.3 0.41 10.0 25.6 1.8 2 0 0 2 2 2 0 ABC-2 type transporter GH3 PF03321.13 PIK48473.1 - 0.05 12.5 0.1 0.072 11.9 0.1 1.1 1 0 0 1 1 1 0 GH3 auxin-responsive promoter DUF2200 PF09966.9 PIK48475.1 - 4.8e-05 23.5 0.0 7.1 6.8 0.0 5.0 6 0 0 6 6 6 3 Uncharacterized protein conserved in bacteria (DUF2200) Exo70 PF03081.15 PIK48477.1 - 0.011 14.8 0.5 0.12 11.4 0.1 2.3 2 1 0 2 2 2 0 Exo70 exocyst complex subunit GrpE PF01025.19 PIK48477.1 - 0.035 13.8 0.3 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 GrpE PLU-1 PF08429.11 PIK48477.1 - 0.047 12.9 0.7 0.18 10.9 0.0 2.0 2 1 0 2 2 2 0 PLU-1-like protein Flu_M1_C PF08289.11 PIK48477.1 - 0.13 12.5 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Sushi PF00084.20 PIK48478.1 - 9.3e-42 141.4 39.8 3.7e-09 37.1 0.5 8.7 9 0 0 9 9 9 7 Sushi repeat (SCR repeat) ig PF00047.25 PIK48478.1 - 2.3e-08 34.1 0.6 3.3e-05 24.0 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK48478.1 - 3.2e-08 34.0 1.2 0.0061 17.1 0.0 4.5 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.6 PIK48478.1 - 8.5e-05 22.8 9.2 0.09 13.1 0.0 5.1 4 1 1 5 5 5 2 Immunoglobulin domain F5_F8_type_C PF00754.25 PIK48478.1 - 0.00074 19.6 0.1 0.0019 18.3 0.1 1.8 1 0 0 1 1 1 1 F5/8 type C domain V-set PF07686.17 PIK48478.1 - 0.0012 18.9 0.3 1.1 9.4 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain DUF281 PF03436.13 PIK48478.1 - 0.0013 19.1 11.3 0.094 13.1 0.5 4.2 3 1 0 3 3 3 2 Domain of unknown function (DUF281) I-set PF07679.16 PIK48478.1 - 0.0052 16.8 0.0 9.9 6.3 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain HRM PF02793.22 PIK48478.1 - 0.18 12.1 25.3 2.4 8.5 2.1 5.5 4 1 1 5 5 5 0 Hormone receptor domain cEGF PF12662.7 PIK48478.1 - 1.6 8.7 6.2 29 4.7 0.4 4.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK48479.1 - 4.5e-51 171.3 29.1 1.2e-09 38.6 0.1 6.7 7 0 0 7 7 7 6 Sushi repeat (SCR repeat) HRM PF02793.22 PIK48479.1 - 7.3e-06 26.2 26.3 0.78 10.1 0.3 6.7 6 1 0 6 6 6 5 Hormone receptor domain Ig_3 PF13927.6 PIK48479.1 - 0.0032 18.0 0.4 0.39 11.4 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin domain Ig_2 PF13895.6 PIK48479.1 - 0.039 14.3 2.4 0.43 11.0 0.2 3.7 4 1 1 5 5 5 0 Immunoglobulin domain cEGF PF12662.7 PIK48479.1 - 0.41 10.6 19.3 3 7.9 0.4 5.7 6 0 0 6 6 6 0 Complement Clr-like EGF-like GAPES4 PF17157.4 PIK48480.1 - 2.5e-07 31.0 14.3 3.2 8.2 0.3 7.4 1 1 7 9 9 9 3 Gammaproteobacterial periplasmic sensor domain ADH_N_assoc PF13823.6 PIK48480.1 - 0.051 13.5 3.6 2.2e+02 1.9 0.0 5.6 5 0 0 5 5 5 0 Alcohol dehydrogenase GroES-associated dCache_3 PF14827.6 PIK48480.1 - 0.053 13.1 0.9 77 2.8 0.0 5.0 1 1 3 4 4 4 0 Double sensory domain of two-component sensor kinase TP6A_N PF04406.14 PIK48480.1 - 0.13 12.2 18.3 34 4.5 0.0 7.1 2 1 4 6 6 6 0 Type IIB DNA topoisomerase FSH1 PF03959.13 PIK48480.1 - 0.35 10.5 3.5 15 5.2 0.2 3.5 2 2 1 3 3 3 0 Serine hydrolase (FSH1) TMEM61 PF15105.6 PIK48480.1 - 0.36 10.6 14.8 52 3.6 0.1 7.8 4 1 6 10 10 10 0 TMEM61 protein family DUF5045 PF16464.5 PIK48480.1 - 2.3 8.6 10.9 41 4.6 0.0 5.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5045) LRR_10 PF18805.1 PIK48481.1 - 0.089 12.5 0.9 2.9 7.6 0.5 2.4 1 1 1 2 2 2 0 Leucine-rich repeat Phage_Gp23 PF10669.9 PIK48482.1 - 0.092 13.1 1.5 0.11 12.8 1.5 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) WD40 PF00400.32 PIK48483.1 - 5.5e-27 93.5 10.8 6.8e-05 23.6 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48483.1 - 2.3e-10 40.7 0.0 0.015 15.6 0.0 5.4 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 PIK48483.1 - 2.2e-05 24.0 0.0 6.7e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 LisH-like dimerisation domain Nup160 PF11715.8 PIK48483.1 - 0.0082 14.8 0.0 0.022 13.4 0.0 1.7 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Lzipper-MIP1 PF14389.6 PIK48483.1 - 1.3 9.4 5.2 0.84 10.0 0.4 2.8 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 WD40 PF00400.32 PIK48484.1 - 6.6e-16 58.4 0.5 6.3e-05 23.7 0.0 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48484.1 - 1e-06 28.9 0.0 0.078 13.3 0.0 2.9 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK48484.1 - 0.00078 18.2 0.0 0.00084 18.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK48484.1 - 0.06 13.2 0.0 1.8 8.4 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A V-set PF07686.17 PIK48485.1 - 5.2e-07 29.8 0.1 0.001 19.2 0.1 3.3 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK48485.1 - 7e-06 26.6 1.5 0.28 11.8 0.0 4.6 5 2 1 6 6 6 2 Immunoglobulin domain ig PF00047.25 PIK48485.1 - 7.4e-05 22.9 1.1 1.1 9.4 0.0 4.7 5 0 0 5 5 5 2 Immunoglobulin domain TMEM154 PF15102.6 PIK48485.1 - 0.00028 20.8 0.1 0.00076 19.4 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family ZU5 PF00791.20 PIK48486.1 - 1.5e-10 41.3 0.0 4.5e-10 39.8 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain HAP1_N PF04849.13 PIK48486.1 - 0.0049 16.1 21.2 0.0049 16.1 21.2 3.0 1 1 1 2 2 2 1 HAP1 N-terminal conserved region DUF4912 PF16258.5 PIK48486.1 - 0.073 13.3 0.0 0.65 10.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4912) HrpB7 PF09486.10 PIK48486.1 - 0.23 11.8 17.7 0.39 11.1 1.0 3.3 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) AAA_19 PF13245.6 PIK48486.1 - 0.66 10.3 8.4 32 4.8 6.1 2.8 2 1 0 2 2 2 0 AAA domain DUF3450 PF11932.8 PIK48486.1 - 3 7.1 41.9 0.096 12.0 9.5 4.1 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) FPP PF05911.11 PIK48486.1 - 4.5 5.3 48.4 2.7 6.1 24.8 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil CENP-F_leu_zip PF10473.9 PIK48486.1 - 5.5 7.0 54.4 42 4.2 19.5 3.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NACHT PF05729.12 PIK48487.1 - 2.8e-18 66.4 0.5 7.5e-18 65.0 0.0 2.1 2 0 0 2 2 2 1 NACHT domain V-set PF07686.17 PIK48487.1 - 5.2e-11 42.7 0.5 6.8e-05 23.0 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 PIK48487.1 - 8e-08 32.3 3.1 0.39 10.9 0.0 5.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_3 PF13927.6 PIK48487.1 - 1.4e-06 28.8 2.2 0.023 15.3 0.0 5.3 4 1 1 5 5 5 1 Immunoglobulin domain AAA_22 PF13401.6 PIK48487.1 - 9.6e-06 25.9 0.0 3.4e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 PIK48487.1 - 0.00011 21.6 0.0 0.00023 20.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Ig_5 PF16681.5 PIK48487.1 - 0.00014 22.2 0.2 0.011 16.1 0.0 3.7 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK48487.1 - 0.00089 19.3 1.4 0.7 10.0 0.1 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain TMEM154 PF15102.6 PIK48487.1 - 0.00089 19.2 2.0 0.0014 18.5 0.9 1.9 2 0 0 2 2 2 1 TMEM154 protein family AAA_16 PF13191.6 PIK48487.1 - 0.0024 18.3 0.0 0.0059 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 PIK48487.1 - 0.0082 15.7 0.0 0.026 14.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK48487.1 - 0.015 15.7 0.0 0.075 13.4 0.0 2.3 1 0 0 1 1 1 0 RNA helicase Shisa PF13908.6 PIK48487.1 - 0.044 14.0 0.7 0.089 13.0 0.7 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator IstB_IS21 PF01695.17 PIK48487.1 - 0.1 12.3 0.6 0.82 9.4 0.0 2.5 2 1 0 3 3 3 0 IstB-like ATP binding protein EphA2_TM PF14575.6 PIK48487.1 - 0.2 12.5 0.7 0.49 11.3 0.2 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain ZU5 PF00791.20 PIK48488.1 - 0.00022 21.5 0.1 0.00044 20.5 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain DUF1818 PF08848.11 PIK48489.1 - 0.061 13.4 6.8 0.25 11.5 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1818) TSC22 PF01166.18 PIK48489.1 - 0.084 13.2 6.7 0.38 11.1 0.6 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family LapA_dom PF06305.11 PIK48489.1 - 0.6 10.0 0.1 0.6 10.0 0.1 4.2 4 1 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Prominin PF05478.11 PIK48489.1 - 3.2 5.6 9.9 4.6 5.1 9.9 1.3 1 0 0 1 1 1 0 Prominin RmuC PF02646.16 PIK48489.1 - 4.4 6.3 21.5 2.9 7.0 10.4 2.4 1 1 1 2 2 2 0 RmuC family NACHT PF05729.12 PIK48490.1 - 5.6e-10 39.4 0.0 1.1e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK48490.1 - 2.5e-06 27.5 1.5 6.4e-06 26.2 0.7 2.0 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain AAA_22 PF13401.6 PIK48490.1 - 5.5e-05 23.5 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK48490.1 - 0.013 15.0 0.0 0.03 13.9 0.0 1.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK48490.1 - 0.066 13.6 0.2 0.38 11.2 0.0 2.5 2 1 0 2 2 2 0 RNA helicase RsgA_GTPase PF03193.16 PIK48490.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Nicastrin PF05450.15 PIK48491.1 - 5.1e-43 147.2 0.0 9.7e-43 146.3 0.0 1.4 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 PIK48491.1 - 8.5e-36 123.5 0.1 1.5e-22 80.4 0.1 2.5 2 0 0 2 2 2 2 Nicastrin small lobe RT_RNaseH_2 PF17919.1 PIK48492.1 - 1.1e-31 108.8 0.1 2.4e-31 107.7 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48492.1 - 1.9e-28 98.8 0.0 3.2e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48493.1 - 4e-22 78.8 0.0 7e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK48493.1 - 0.0091 16.5 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease DUF4125 PF13526.6 PIK48493.1 - 0.017 14.7 0.0 0.044 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) Retrotrans_gag PF03732.17 PIK48493.1 - 0.05 13.9 0.2 0.12 12.7 0.2 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein Asp_protease_2 PF13650.6 PIK48493.1 - 0.092 13.4 0.0 0.18 12.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease FmdE PF02663.14 PIK48493.1 - 0.098 12.7 0.1 0.31 11.1 0.1 1.8 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon DUF1643 PF07799.12 PIK48493.1 - 0.11 12.7 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) zf-CCHC PF00098.23 PIK48493.1 - 0.8 9.9 7.1 3 8.1 7.1 2.1 1 0 0 1 1 1 0 Zinc knuckle DUF4806 PF16064.5 PIK48494.1 - 2.8e-12 46.8 0.0 1.1e-11 44.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4806) RE_XamI PF09572.10 PIK48494.1 - 0.0044 16.7 0.1 0.0064 16.2 0.1 1.2 1 0 0 1 1 1 1 XamI restriction endonuclease RVT_1 PF00078.27 PIK48496.1 - 5.7e-18 65.3 0.0 8e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48496.1 - 0.00078 19.4 0.1 0.0017 18.3 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_thumb PF06817.14 PIK48496.1 - 0.034 14.0 0.0 0.084 12.7 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase thumb domain Aconitase PF00330.20 PIK48497.1 - 1e-11 44.5 0.0 1.2e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase PF00330.20 PIK48498.1 - 9.6e-150 499.6 0.0 1.2e-149 499.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 PIK48498.1 - 8.9e-45 152.2 0.1 6.2e-43 146.3 0.0 2.8 3 0 0 3 3 3 1 Aconitase C-terminal domain CSD2 PF17876.1 PIK48498.1 - 0.013 15.7 0.3 0.45 10.7 0.0 3.2 4 0 0 4 4 4 0 Cold shock domain Med16 PF11635.8 PIK48499.1 - 7.8e-26 90.2 0.0 9.8e-13 46.9 0.0 2.0 1 1 1 2 2 2 2 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 PIK48499.1 - 4.3e-06 26.9 0.2 0.4 11.0 0.0 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK48499.1 - 0.48 11.4 2.6 42 5.2 0.0 4.1 5 0 0 5 5 5 0 WD domain, G-beta repeat Rad51 PF08423.11 PIK48500.1 - 2.2e-05 23.9 0.0 3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 Cytochrom_B561 PF03188.16 PIK48501.1 - 1.2e-43 148.5 13.8 6.9e-42 142.8 11.8 2.1 2 0 0 2 2 2 2 Eukaryotic cytochrome b561 ABC_trans_CmpB PF06541.11 PIK48501.1 - 0.26 11.5 11.0 0.19 12.0 2.6 2.2 2 0 0 2 2 2 0 Putative ABC-transporter type IV MARVEL PF01284.23 PIK48501.1 - 0.95 9.5 12.7 1.9 8.5 0.6 2.7 3 0 0 3 3 3 0 Membrane-associating domain DUF3810 PF12725.7 PIK48501.1 - 6.9 5.9 7.8 1.3 8.3 1.8 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3810) DUF4079 PF13301.6 PIK48501.1 - 9.1 6.4 16.7 2.6 8.2 9.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) SUR7 PF06687.12 PIK48501.1 - 9.1 5.8 17.1 1.3 8.6 9.8 2.2 1 1 1 2 2 2 0 SUR7/PalI family FAD_binding_1 PF00667.20 PIK48504.1 - 8.8e-43 146.4 0.0 1.3e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 PIK48504.1 - 1.8e-18 67.1 0.0 6.7e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 PIK48504.1 - 2.4e-16 60.3 0.1 4.4e-16 59.5 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF3357 PF11837.8 PIK48504.1 - 3.2 8.3 6.5 29 5.2 0.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Phage_int_SAM_4 PF13495.6 PIK48505.1 - 0.045 14.2 0.0 0.095 13.2 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK48505.1 - 0.071 12.9 0.0 0.2 11.4 0.0 1.8 1 1 0 1 1 1 0 Phage integrase family Phage_int_SAM_1 PF02899.17 PIK48505.1 - 0.082 13.2 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain DUF4064 PF13273.6 PIK48506.1 - 0.093 13.0 3.0 0.42 10.9 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SSF PF00474.17 PIK48507.1 - 1.7e-08 33.8 26.1 3.8e-08 32.6 26.1 1.5 1 1 0 1 1 1 1 Sodium:solute symporter family Ndc1_Nup PF09531.10 PIK48507.1 - 5.2 5.6 5.4 8.2 5.0 5.4 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Exo_endo_phos_2 PF14529.6 PIK48508.1 - 0.089 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Ig_C17orf99 PF17736.1 PIK48508.1 - 0.12 12.5 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 C17orf99 Ig domain zf-C2H2_4 PF13894.6 PIK48509.1 - 2.9e-10 40.1 26.3 0.0018 18.9 4.0 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK48509.1 - 7.2e-10 38.8 29.0 0.0017 18.7 2.1 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK48509.1 - 7.9e-10 38.7 20.5 0.00023 21.5 0.7 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK48509.1 - 2.1e-05 24.6 15.0 0.06 13.7 2.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK48509.1 - 3.7e-05 24.0 16.5 0.0011 19.3 1.3 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK48509.1 - 0.00056 19.8 4.4 0.045 13.6 0.5 3.2 3 0 0 3 3 3 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 PIK48509.1 - 0.001 19.0 14.8 0.47 10.5 0.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-AN1 PF01428.16 PIK48509.1 - 0.0041 17.3 19.1 0.006 16.7 2.8 3.5 1 1 2 3 3 3 1 AN1-like Zinc finger zf-Di19 PF05605.12 PIK48509.1 - 0.0066 16.7 15.2 0.17 12.2 1.9 2.6 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 PIK48509.1 - 0.0068 16.1 13.0 0.22 11.3 1.6 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type DUF629 PF04780.12 PIK48509.1 - 0.056 12.0 14.1 1.5 7.3 6.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF629) Zn-ribbon_8 PF09723.10 PIK48509.1 - 0.077 13.1 9.3 4.4 7.5 0.7 3.5 3 0 0 3 3 3 0 Zinc ribbon domain zf-Dof PF02701.15 PIK48509.1 - 0.083 13.0 12.7 0.24 11.6 0.2 3.1 1 1 2 3 3 3 0 Dof domain, zinc finger zinc_ribbon_15 PF17032.5 PIK48509.1 - 0.11 13.2 5.1 2.2 9.1 4.6 2.2 1 1 1 2 2 2 0 zinc-ribbon family zinc-ribbons_6 PF07191.12 PIK48509.1 - 0.13 12.2 8.9 1.2 9.2 3.4 2.7 1 1 2 3 3 3 0 zinc-ribbons zf-C2HC_2 PF13913.6 PIK48509.1 - 0.21 11.5 14.2 1.1 9.2 1.2 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zinc_ribbon_10 PF10058.9 PIK48509.1 - 0.22 11.3 5.1 1.5 8.6 0.1 3.1 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Rad50_zn_hook PF04423.14 PIK48509.1 - 0.23 11.3 3.5 0.52 10.2 0.1 2.5 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-C2H2_3rep PF18868.1 PIK48509.1 - 0.36 11.5 8.1 1 10.1 2.5 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats LIM PF00412.22 PIK48509.1 - 0.51 10.6 9.2 8.3 6.7 0.1 3.2 2 1 1 3 3 3 0 LIM domain Sgf11 PF08209.11 PIK48509.1 - 0.53 9.9 7.1 1.4 8.5 0.3 3.2 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-C2H2_2 PF12756.7 PIK48509.1 - 0.57 10.5 14.1 2.9 8.3 0.8 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 PIK48509.1 - 0.72 10.5 5.4 1.7 9.3 4.9 1.8 1 1 1 2 2 2 0 FOXP coiled-coil domain CpXC PF14353.6 PIK48509.1 - 0.76 9.8 7.6 8.5 6.4 2.9 2.9 1 1 2 3 3 3 0 CpXC protein DUF2256 PF10013.9 PIK48509.1 - 0.87 9.8 10.3 2.5 8.3 0.2 3.5 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Zf_RING PF16744.5 PIK48509.1 - 0.93 9.6 11.1 3.4 7.9 1.0 3.1 1 1 2 3 3 3 0 KIAA1045 RING finger ADK_lid PF05191.14 PIK48509.1 - 1.3 9.1 6.7 16 5.5 6.2 2.4 1 1 0 1 1 1 0 Adenylate kinase, active site lid GAGA PF09237.11 PIK48509.1 - 1.4 8.8 5.9 8.5 6.3 0.2 2.6 1 1 2 3 3 3 0 GAGA factor Desulfoferrod_N PF06397.12 PIK48509.1 - 1.4 8.6 5.9 1.5 8.5 0.7 2.4 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-C2HE PF16278.5 PIK48509.1 - 1.8 9.1 11.8 1.4e+02 3.0 7.4 3.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Endonuclease_7 PF02945.15 PIK48509.1 - 1.9 8.4 10.5 1.1 9.2 7.4 2.0 1 1 1 2 2 2 0 Recombination endonuclease VII zf-BED PF02892.15 PIK48509.1 - 5.3 7.2 18.4 0.7 10.0 5.0 3.2 2 1 1 3 3 3 0 BED zinc finger IBR PF01485.21 PIK48509.1 - 5.6 7.3 11.4 1.3 9.3 7.4 1.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf_UBZ PF18439.1 PIK48509.1 - 7.8 6.2 10.3 9.3 5.9 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Mut7-C PF01927.16 PIK48509.1 - 9.3 6.3 9.0 1.8 8.7 0.1 2.6 1 1 1 2 2 2 0 Mut7-C RNAse domain PBD PF00786.28 PIK48510.1 - 0.0018 18.6 0.1 0.0035 17.7 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain zf-nanos PF05741.13 PIK48510.1 - 0.14 12.4 0.1 5.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Nanos RNA binding domain FIT1_2 PF17357.2 PIK48511.1 - 9.2e-06 25.7 40.3 1.7 8.8 9.6 9.9 3 2 6 9 9 9 6 Facilitor Of iron transport 1 and 2 Hexapep PF00132.24 PIK48511.1 - 0.0063 16.2 0.1 52 3.8 0.0 5.7 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) CUB PF00431.20 PIK48512.1 - 1.1e-265 862.7 7.4 1.4e-32 112.3 0.0 9.1 9 0 0 9 9 9 9 CUB domain CUB_2 PF02408.20 PIK48512.1 - 2.6e-17 62.7 8.3 0.022 14.5 0.0 9.1 9 0 0 9 9 9 6 CUB-like domain EGF PF00008.27 PIK48512.1 - 8.1e-14 51.6 82.2 2.1e-08 34.3 7.9 7.5 6 1 0 6 6 6 4 EGF-like domain EGF_CA PF07645.15 PIK48512.1 - 3.6e-09 36.7 88.8 6.9e-05 23.0 8.0 6.8 5 1 1 6 6 6 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK48512.1 - 4e-09 36.6 76.3 9.7e-05 22.6 11.3 6.8 3 2 3 6 6 6 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK48512.1 - 2.4e-07 30.9 27.7 1.9e-05 24.8 9.5 6.9 5 1 1 6 6 6 2 EGF domain hEGF PF12661.7 PIK48512.1 - 3.3e-05 24.3 5.4 3.3e-05 24.3 5.4 8.6 7 1 0 7 7 7 1 Human growth factor-like EGF cEGF PF12662.7 PIK48512.1 - 0.00022 21.1 2.5 0.00022 21.1 2.5 8.3 8 0 0 8 8 8 3 Complement Clr-like EGF-like EGF_2 PF07974.13 PIK48512.1 - 0.01 16.2 9.5 0.01 16.2 9.5 7.6 5 1 1 6 6 6 0 EGF-like domain CUB PF00431.20 PIK48513.1 - 2.7e-265 861.4 0.1 1e-30 106.3 0.0 12.0 12 0 0 12 12 12 12 CUB domain CUB_2 PF02408.20 PIK48513.1 - 3.8e-10 39.6 9.3 0.043 13.6 0.1 8.6 9 1 0 9 9 9 4 CUB-like domain IL4Ra_N PF09238.10 PIK48513.1 - 2 8.8 5.1 1.7e+02 2.6 0.0 5.2 6 1 0 6 6 6 0 Interleukin-4 receptor alpha chain, N-terminal CUB PF00431.20 PIK48514.1 - 3.3e-115 378.2 3.8 1.8e-30 105.5 0.0 7.7 8 0 0 8 8 8 6 CUB domain 7tm_1 PF00001.21 PIK48515.1 - 1.8e-29 102.9 18.5 2.5e-29 102.4 18.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UQ_con PF00179.26 PIK48516.1 - 1.8e-11 43.8 0.3 3.4e-11 43.0 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK48516.1 - 0.02 14.7 0.0 0.053 13.4 0.0 1.6 2 0 0 2 2 2 0 UEV domain 7tm_1 PF00001.21 PIK48518.1 - 9.4e-42 143.1 24.2 1.4e-41 142.6 24.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK48518.1 - 1.8e-06 27.8 18.6 1.8e-06 27.8 18.6 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK48518.1 - 3.3e-05 23.4 23.6 4.3e-05 23.0 23.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK48518.1 - 0.00071 18.9 22.0 0.17 11.1 22.0 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF996 PF06195.13 PIK48518.1 - 3.3 8.0 15.1 0.38 11.0 3.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF996) NOG1_N PF17835.1 PIK48519.1 - 8e-41 139.7 3.5 4.8e-39 133.9 3.5 2.9 1 1 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 PIK48519.1 - 2.9e-25 87.8 0.1 5.8e-25 86.8 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 PIK48519.1 - 2.4e-17 63.0 0.0 7.9e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase NOGCT PF08155.11 PIK48519.1 - 8.1e-17 61.0 1.8 8.1e-17 61.0 1.8 2.1 2 0 0 2 2 2 1 NOGCT (NUC087) domain FeoB_N PF02421.18 PIK48519.1 - 2.3e-11 43.5 0.0 4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK48519.1 - 0.0012 18.9 2.6 0.72 9.9 0.0 3.5 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK48519.1 - 0.0015 18.5 0.1 3.4 7.5 0.0 3.0 2 1 0 2 2 2 2 RsgA GTPase Arf PF00025.21 PIK48519.1 - 0.032 13.7 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 PIK48519.1 - 0.051 13.6 0.4 0.7 9.9 0.0 2.6 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 PIK48519.1 - 0.061 13.7 0.0 0.29 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain SurA_N PF09312.11 PIK48519.1 - 0.081 13.0 0.5 0.22 11.6 0.5 1.7 1 0 0 1 1 1 0 SurA N-terminal domain Peptidase_M8 PF01457.16 PIK48520.1 - 3.7e-44 151.3 12.9 1.4e-42 146.1 9.8 4.0 2 2 1 3 3 3 1 Leishmanolysin PEX11 PF05648.14 PIK48520.1 - 2.3e-10 40.3 0.5 5e-10 39.2 0.5 1.5 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) WAP PF00095.21 PIK48520.1 - 7.2e-09 35.9 15.1 7.2e-09 35.9 15.1 2.7 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Ribosomal_L32p PF01783.23 PIK48521.1 - 3.6e-06 27.1 2.9 5.8e-06 26.5 2.9 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family DUF1248 PF06852.12 PIK48521.1 - 0.0042 16.6 0.0 0.0062 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1248) Prok-RING_1 PF14446.6 PIK48521.1 - 0.076 13.0 1.8 0.26 11.2 1.8 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 HELP PF03451.14 PIK48522.1 - 1.6e-21 75.9 0.2 3.5e-21 74.8 0.2 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 PIK48522.1 - 1.4e-16 60.5 19.0 0.028 15.3 3.0 8.7 8 1 1 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48522.1 - 1.3e-08 35.0 0.0 0.00054 20.2 0.0 4.5 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5580 PF17743.1 PIK48522.1 - 4.7e-07 28.7 0.0 4.7e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5580) Ge1_WD40 PF16529.5 PIK48522.1 - 0.00076 18.5 0.2 0.0018 17.3 0.0 1.6 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein EF-hand_8 PF13833.6 PIK48522.1 - 0.11 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair adh_short PF00106.25 PIK48524.1 - 1.2e-41 142.4 0.0 1.6e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK48524.1 - 1.9e-26 93.0 0.0 2.7e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK48524.1 - 4.2e-11 43.1 0.0 6.1e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 KR domain FMO-like PF00743.19 PIK48524.1 - 0.0051 15.3 0.0 0.0082 14.6 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like 2-Hacid_dh_C PF02826.19 PIK48524.1 - 0.039 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 PIK48524.1 - 0.045 13.1 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Tti2 PF10521.9 PIK48525.1 - 5.7e-14 52.3 0.1 4.4e-13 49.4 0.1 2.3 2 1 0 2 2 2 1 Tti2 family WD40 PF00400.32 PIK48526.1 - 3.6e-31 106.7 6.6 1.3e-06 29.0 0.0 6.9 7 0 0 7 7 6 6 WD domain, G-beta repeat SAM_1 PF00536.30 PIK48526.1 - 1.4e-20 73.5 0.1 2.3e-20 72.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK48526.1 - 1.2e-19 70.1 0.1 2e-19 69.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ANAPC4_WD40 PF12894.7 PIK48526.1 - 1.2e-07 31.9 0.0 0.069 13.5 0.0 3.7 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 PIK48526.1 - 1.5e-07 31.5 0.1 3.1e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 U-box domain Ge1_WD40 PF16529.5 PIK48526.1 - 0.00016 20.7 0.4 0.39 9.6 0.0 3.6 2 2 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SAM_3 PF18016.1 PIK48526.1 - 0.0036 17.1 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK48526.1 - 0.015 15.2 0.0 0.085 12.8 0.0 2.1 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain PD40 PF07676.12 PIK48526.1 - 0.066 13.2 0.2 2.4 8.2 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cerato-platanin PF07249.12 PIK48526.1 - 0.078 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Cerato-platanin zf-NOSIP PF15906.5 PIK48526.1 - 0.15 12.2 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein AAA_8 PF12780.7 PIK48527.1 - 4.7e-93 311.2 0.0 8.9e-93 310.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 PIK48527.1 - 6.8e-91 304.7 0.5 2.8e-90 302.7 0.1 2.3 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 PIK48527.1 - 1.2e-89 299.3 1.0 3e-87 291.4 0.5 3.1 2 1 0 2 2 2 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK48527.1 - 8.9e-57 191.5 0.1 2.1e-56 190.2 0.1 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK48527.1 - 1.4e-44 151.0 0.0 2.3e-43 147.1 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK48527.1 - 1.4e-44 152.5 13.9 6.9e-22 77.9 0.2 2.2 1 1 1 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 PIK48527.1 - 0.0031 17.5 0.0 0.024 14.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) SlyX PF04102.12 PIK48527.1 - 0.76 10.4 6.8 14 6.4 1.3 4.1 3 1 1 4 4 4 0 SlyX Spc7 PF08317.11 PIK48527.1 - 2.1 7.1 23.4 0.071 12.0 2.5 3.3 3 0 0 3 3 3 0 Spc7 kinetochore protein DHC_N2 PF08393.13 PIK48528.1 - 3.7e-136 454.4 8.3 3.7e-136 454.4 8.3 4.2 3 2 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 PIK48528.1 - 2.7e-127 425.8 14.5 5.5e-91 305.9 4.4 3.4 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 PIK48528.1 - 2e-84 283.4 14.4 1.7e-42 145.5 0.3 5.7 5 1 1 6 6 6 4 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 PIK48528.1 - 1.1e-71 240.1 3.9 2.8e-66 222.5 0.0 3.5 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_5 PF07728.14 PIK48528.1 - 1.3e-16 60.8 0.3 8.3e-09 35.6 0.0 4.3 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 PIK48528.1 - 5.5e-14 52.4 0.0 6.2e-13 49.0 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 PIK48528.1 - 1.5e-09 38.2 0.2 0.0064 16.8 0.0 4.8 4 0 0 4 4 3 2 AAA domain AAA PF00004.29 PIK48528.1 - 2.4e-08 34.5 0.1 0.34 11.3 0.0 4.5 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK48528.1 - 2.5e-07 31.2 0.0 0.22 11.9 0.0 4.3 3 0 0 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 PIK48528.1 - 0.0002 21.7 0.1 1.9 8.9 0.0 4.0 3 0 0 3 3 3 1 RNA helicase AAA_18 PF13238.6 PIK48528.1 - 0.003 18.1 0.0 0.65 10.6 0.0 3.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 PIK48528.1 - 0.0033 17.3 0.0 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase PhoH PF02562.16 PIK48528.1 - 0.0033 16.9 2.4 0.029 13.8 0.1 3.2 2 1 1 3 3 3 1 PhoH-like protein T2SSE PF00437.20 PIK48528.1 - 0.0035 16.4 0.8 0.71 8.9 0.2 3.1 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.6 PIK48528.1 - 0.0046 16.7 3.9 0.47 10.2 0.2 3.4 4 0 0 4 4 3 1 AAA domain Sigma54_activat PF00158.26 PIK48528.1 - 0.0095 15.7 0.1 2.6 7.7 0.1 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 PIK48528.1 - 0.013 15.9 4.2 3.7 7.9 0.4 3.6 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 PIK48528.1 - 0.022 14.9 0.1 19 5.4 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 PIK48528.1 - 0.034 14.4 0.4 12 6.1 0.0 3.1 2 0 0 2 2 2 0 AAA domain DUF3909 PF13077.6 PIK48528.1 - 0.074 13.2 0.1 0.29 11.3 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3909) Rad17 PF03215.15 PIK48528.1 - 0.22 11.5 5.8 38 4.1 0.0 5.1 6 0 0 6 6 5 0 Rad17 P-loop domain DUF853 PF05872.12 PIK48528.1 - 0.3 9.6 3.2 0.97 8.0 0.4 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) TsaE PF02367.17 PIK48528.1 - 0.33 11.0 1.8 56 3.7 0.1 3.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 PIK48528.1 - 0.62 8.9 4.1 9.3 5.0 0.1 2.8 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.22 PIK48528.1 - 1.6 8.3 5.6 5.8 6.5 0.6 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain SesA PF17107.5 PIK48528.1 - 5.1 7.3 6.0 6.6 6.9 0.1 4.2 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases COesterase PF00135.28 PIK48529.1 - 2.3e-110 369.9 0.0 2e-109 366.8 0.0 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK48529.1 - 1.5e-12 47.9 0.6 6.6e-12 45.7 0.2 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK48529.1 - 0.00033 20.2 1.9 0.00034 20.2 0.1 1.9 3 0 0 3 3 3 1 Prolyl oligopeptidase family AChE_tetra PF08674.10 PIK48529.1 - 0.00038 20.1 4.1 0.00074 19.2 4.1 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_6 PF12697.7 PIK48529.1 - 0.0016 19.1 0.0 0.0038 17.8 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 PIK48529.1 - 0.0045 15.9 0.0 0.037 12.9 0.0 2.0 1 1 0 1 1 1 1 Steryl acetyl hydrolase HSP70 PF00012.20 PIK48530.1 - 1.8e-127 426.1 2.6 1.6e-80 271.0 0.4 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK48530.1 - 7.7e-11 41.4 0.0 1.2e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein StbA PF06406.11 PIK48530.1 - 0.0082 15.4 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 StbA protein NMD3 PF04981.13 PIK48530.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 NMD3 family Hydantoinase_A PF01968.18 PIK48530.1 - 0.03 13.6 0.0 0.059 12.6 0.0 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Methyltransf_14 PF08484.11 PIK48530.1 - 0.043 13.6 0.1 0.12 12.2 0.0 1.7 1 1 0 1 1 1 0 C-methyltransferase C-terminal domain DUF1631 PF07793.11 PIK48530.1 - 0.2 10.1 1.3 0.27 9.6 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) DUF1843 PF08898.10 PIK48530.1 - 0.95 10.0 3.7 0.72 10.4 1.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) HSP70 PF00012.20 PIK48531.1 - 2.5e-35 121.8 0.0 2.7e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein LRR_9 PF14580.6 PIK48532.1 - 1.1e-11 44.6 1.3 1.1e-11 44.6 1.3 1.9 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 PIK48532.1 - 0.00054 20.3 12.6 0.00098 19.5 3.8 2.9 1 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK48532.1 - 0.00058 19.6 2.7 0.00058 19.6 2.7 2.7 1 1 1 2 2 2 1 Leucine rich repeat Speriolin_N PF15058.6 PIK48532.1 - 0.2 11.7 1.2 0.6 10.2 1.2 1.8 1 0 0 1 1 1 0 Speriolin N terminus LRR_6 PF13516.6 PIK48532.1 - 0.65 10.2 8.8 4.9 7.5 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeat Com_YlbF PF06133.11 PIK48532.1 - 1.8 9.2 8.8 0.85 10.3 2.3 3.0 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA eIF-5_eIF-2B PF01873.17 PIK48533.1 - 1e-40 138.3 0.3 2.9e-40 136.8 0.3 1.8 1 0 0 1 1 1 1 Domain found in IF2B/IF5 ATPase PF06745.13 PIK48533.1 - 2.7 7.3 6.6 0.34 10.2 0.7 2.3 3 1 0 3 3 3 0 KaiC EamA PF00892.20 PIK48534.1 - 1.5e-22 80.2 43.1 1.8e-13 50.8 12.7 2.0 2 0 0 2 2 2 2 EamA-like transporter family DUF5423 PF17461.2 PIK48534.1 - 0.84 8.4 4.3 1.1 8.0 3.7 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5423) Ist1 PF03398.14 PIK48535.1 - 2.9e-60 202.9 2.1 3.9e-60 202.5 2.1 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Fucokinase PF07959.12 PIK48536.1 - 1.6e-75 254.5 0.0 2.3e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.13 PIK48537.1 - 1.5e-06 28.4 0.0 3.2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal MTA_R1 PF17226.2 PIK48537.1 - 0.061 13.5 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 MTA R1 domain WD40 PF00400.32 PIK48539.1 - 6.9e-23 80.5 12.6 4.3e-07 30.5 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat UCH_1 PF13423.6 PIK48540.1 - 0.08 12.5 0.7 2 8.0 0.7 2.1 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DNA_pol_B_N PF18094.1 PIK48540.1 - 0.15 12.7 0.0 0.22 12.1 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase beta N-terminal domain zf-B_box PF00643.24 PIK48540.1 - 0.25 11.5 6.1 1.2 9.3 0.3 2.4 2 0 0 2 2 2 0 B-box zinc finger Churchill PF06573.11 PIK48540.1 - 0.99 9.8 5.7 1.3 9.4 4.9 1.5 1 1 0 1 1 1 0 Churchill protein Death PF00531.22 PIK48541.1 - 1.6e-28 98.7 27.0 4.1e-05 23.6 0.1 7.3 7 0 0 7 7 7 5 Death domain CAP_GLY PF01302.25 PIK48541.1 - 3.1e-14 52.7 1.9 8.7e-10 38.5 0.2 2.6 2 0 0 2 2 2 2 CAP-Gly domain CPT_N PF16484.5 PIK48541.1 - 0.00037 20.4 0.3 1.9 8.6 0.0 3.1 3 0 0 3 3 3 2 Carnitine O-palmitoyltransferase N-terminus Death_2 PF14786.6 PIK48541.1 - 0.12 12.4 2.3 6.7 6.6 0.0 3.8 5 0 0 5 5 5 0 Tube Death domain CAP_GLY PF01302.25 PIK48542.1 - 0.00031 20.7 0.2 0.0007 19.6 0.2 1.6 1 0 0 1 1 1 1 CAP-Gly domain Death PF00531.22 PIK48543.1 - 8.8e-29 99.5 6.9 5.2e-08 32.9 0.2 5.2 5 0 0 5 5 5 4 Death domain CPT_N PF16484.5 PIK48543.1 - 3.9e-05 23.6 0.0 0.27 11.3 0.0 3.0 2 0 0 2 2 2 2 Carnitine O-palmitoyltransferase N-terminus EcoEI_R_C PF08463.10 PIK48543.1 - 0.025 14.7 0.2 0.51 10.4 0.1 2.3 2 0 0 2 2 2 0 EcoEI R protein C-terminal IRK_C PF17655.1 PIK48544.1 - 1.9e-70 236.0 0.0 2.8e-70 235.5 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 PIK48544.1 - 1.9e-57 193.1 4.7 2.7e-57 192.6 4.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 PIK48544.1 - 0.0094 15.9 5.0 0.026 14.5 5.0 1.8 1 1 0 1 1 1 1 Ion channel PUD1_2 PF18457.1 PIK48544.1 - 0.26 11.2 0.9 1.5 8.8 0.1 2.4 2 0 0 2 2 2 0 Up-Regulated in long-lived daf-2 LMF1 PF06762.14 PIK48545.1 - 1.6e-142 475.7 10.6 1.9e-72 244.8 5.1 2.2 1 1 1 2 2 2 2 Lipase maturation factor PALP PF00291.25 PIK48546.1 - 3.1e-12 46.5 0.0 3.8e-12 46.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Homeodomain PF00046.29 PIK48547.1 - 1.1e-25 89.3 1.0 2.2e-25 88.2 1.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK48547.1 - 0.00023 21.0 0.2 0.0015 18.4 0.0 2.5 3 0 0 3 3 3 1 Homeobox KN domain DUF423 PF04241.15 PIK48548.1 - 1.4e-18 66.9 2.5 1.9e-18 66.4 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF423) HA2 PF04408.23 PIK48549.1 - 9.7e-19 67.7 0.0 2.1e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 PIK48549.1 - 5.2e-15 55.7 0.0 1.5e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 PIK48549.1 - 1.6e-12 47.6 0.0 3.4e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK48549.1 - 1.6e-09 37.8 1.2 3.2e-08 33.6 0.8 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK48549.1 - 3e-06 27.6 0.1 7.3e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK48549.1 - 0.00022 21.6 0.8 0.00047 20.5 0.8 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK48549.1 - 0.0059 16.6 0.4 0.15 12.1 0.4 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 PIK48549.1 - 0.0067 16.2 0.8 0.012 15.3 0.8 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 PIK48549.1 - 0.022 15.3 0.6 1.1 9.7 0.6 2.6 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 PIK48549.1 - 0.022 13.8 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 PIK48549.1 - 0.057 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family FeoA PF04023.14 PIK48549.1 - 0.14 12.4 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 FeoA domain zf-B_box PF00643.24 PIK48550.1 - 0.0011 19.1 3.0 0.0016 18.5 3.0 1.3 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.21 PIK48550.1 - 0.16 12.2 3.7 0.38 11.0 3.7 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CEBP_ZZ PF16366.5 PIK48550.1 - 0.29 11.4 4.2 0.71 10.2 4.2 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain ArfGap PF01412.18 PIK48550.1 - 0.96 9.5 4.2 0.36 10.9 0.7 2.1 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf RNA_pol_Rpb1_R PF05001.13 PIK48550.1 - 7.6 7.1 8.2 0.49 10.9 2.6 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat Na_Ca_ex PF01699.24 PIK48551.1 - 1.5e-49 167.8 37.0 6.2e-25 87.9 16.1 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF996 PF06195.13 PIK48551.1 - 0.028 14.7 1.2 0.028 14.7 1.2 3.9 4 1 0 4 4 4 0 Protein of unknown function (DUF996) DUF485 PF04341.12 PIK48551.1 - 0.48 10.4 0.1 0.48 10.4 0.1 4.7 5 1 0 5 5 5 0 Protein of unknown function, DUF485 ETX_MTX2 PF03318.13 PIK48552.1 - 4.5e-07 29.9 6.2 5.1e-07 29.7 6.2 1.1 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK48552.1 - 0.014 14.6 0.8 0.016 14.4 0.8 1.0 1 0 0 1 1 1 0 Aerolysin toxin Vps62 PF06101.11 PIK48553.1 - 2.6e-16 59.1 0.0 3.6e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 zf-CCHC PF00098.23 PIK48554.1 - 0.0001 22.2 2.6 0.00017 21.5 2.6 1.4 1 0 0 1 1 1 1 Zinc knuckle PHD_4 PF16866.5 PIK48554.1 - 0.015 15.4 0.3 0.042 13.9 0.3 1.8 1 0 0 1 1 1 0 PHD-finger DUF3528 PF12045.8 PIK48554.1 - 0.025 15.2 1.7 0.13 12.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3528) Drf_GBD PF06371.13 PIK48554.1 - 0.59 9.7 4.1 0.26 10.8 0.2 2.0 2 1 0 2 2 2 0 Diaphanous GTPase-binding Domain RVP PF00077.20 PIK48556.1 - 0.0024 18.1 0.4 0.033 14.5 0.0 2.5 3 0 0 3 3 3 1 Retroviral aspartyl protease vWF_A PF12450.8 PIK48556.1 - 0.063 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 von Willebrand factor RT_RNaseH_2 PF17919.1 PIK48557.1 - 4.3e-32 110.1 0.6 7.9e-32 109.3 0.3 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48557.1 - 1.3e-31 109.0 0.0 3.1e-31 107.8 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Ribosomal_S7 PF00177.21 PIK48557.1 - 0.057 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e DUF2330 PF10092.9 PIK48558.1 - 0.19 10.8 0.0 0.32 10.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2330) PHD PF00628.29 PIK48559.1 - 1.3e-09 37.8 6.1 3.3e-09 36.5 6.1 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK48559.1 - 0.043 13.4 0.8 0.087 12.4 0.8 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 PIK48559.1 - 0.11 12.4 3.3 0.31 11.0 3.3 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DZR PF12773.7 PIK48559.1 - 0.89 9.6 4.2 2 8.5 4.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon INT_SG_DDX_CT_C PF15300.6 PIK48560.1 - 3.4e-22 78.0 0.2 7.2e-22 77.0 0.2 1.6 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA_2 PF13519.6 PIK48560.1 - 2.1e-21 76.6 0.3 1.5e-20 73.8 0.0 2.6 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 PIK48560.1 - 5.4e-06 26.8 0.0 5.8e-05 23.4 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain RabGAP-TBC PF00566.18 PIK48562.1 - 2.7e-50 171.0 0.8 1.3e-49 168.7 0.8 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF2264 PF10022.9 PIK48563.1 - 0.14 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) tRNA-synt_1e PF01406.19 PIK48564.1 - 5.9e-126 419.9 1.5 9.7e-126 419.2 1.5 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 PIK48564.1 - 3.9e-09 35.8 0.7 6.4e-06 25.2 0.2 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 PIK48564.1 - 0.00048 18.5 0.1 0.0017 16.7 0.0 1.9 3 0 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) Nab2 PF11517.8 PIK48564.1 - 0.012 15.9 0.3 0.12 12.7 0.1 2.7 3 0 0 3 3 3 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) tRNA-synt_1f PF01921.18 PIK48564.1 - 0.017 14.1 0.1 0.071 12.0 0.1 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (K) tRNA-synt_1c PF00749.21 PIK48564.1 - 0.027 13.4 0.0 0.027 13.4 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Dna2 PF08696.11 PIK48564.1 - 0.14 12.0 0.6 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 DNA replication factor Dna2 DUF2870 PF11069.8 PIK48564.1 - 0.47 10.9 5.8 1.3 9.4 5.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) MscS_TM PF12794.7 PIK48564.1 - 0.52 9.1 6.4 0.78 8.5 6.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Exo_endo_phos PF03372.23 PIK48565.1 - 2.5e-08 33.7 0.0 2.3e-07 30.6 0.0 2.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK48565.1 - 0.069 13.0 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase MCM PF00493.23 PIK48566.1 - 2.6e-76 255.6 0.0 4.1e-76 255.0 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK48566.1 - 2.6e-21 75.8 1.8 5.6e-21 74.7 1.8 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK48566.1 - 5.9e-17 61.9 1.9 1.5e-16 60.6 1.9 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 PIK48566.1 - 1.3e-08 34.5 0.1 0.00017 21.0 0.0 2.7 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK48566.1 - 2.3e-08 34.2 0.0 4.3e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK48566.1 - 0.0026 17.6 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK48566.1 - 0.036 13.8 0.0 0.57 9.9 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 PIK48566.1 - 0.046 14.1 0.2 0.14 12.6 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 PIK48566.1 - 0.049 13.3 0.3 0.15 11.8 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 PIK48566.1 - 0.057 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 PIK48566.1 - 0.085 12.6 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 PIK48566.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TMEM125 PF15109.6 PIK48566.1 - 0.15 12.4 0.0 20 5.6 0.0 2.8 2 0 0 2 2 2 0 TMEM125 protein family 7tm_1 PF00001.21 PIK48567.1 - 5.2e-32 111.2 19.4 6.4e-32 110.9 19.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK48567.1 - 1.8e-10 40.9 21.1 1.8e-10 40.9 21.1 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF3810 PF12725.7 PIK48567.1 - 7 5.9 10.0 0.3 10.4 3.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Topoisom_bac PF01131.20 PIK48568.1 - 1.4e-117 393.2 0.0 1.8e-117 392.9 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 PIK48568.1 - 3.4e-14 52.9 0.0 9.3e-14 51.5 0.0 1.8 1 0 0 1 1 1 1 Toprim domain zinc_ribbon_4 PF13717.6 PIK48568.1 - 0.034 14.1 8.8 3.6 7.6 2.3 4.0 3 0 0 3 3 3 0 zinc-ribbon domain DUF4882 PF16223.5 PIK48568.1 - 0.062 12.5 0.0 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4882) Cript PF10235.9 PIK48568.1 - 0.58 10.8 4.2 0.31 11.6 0.7 2.3 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT zinc_ribbon_5 PF13719.6 PIK48568.1 - 9.7 6.1 7.4 24 4.8 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain rRNA_processing PF08524.11 PIK48569.1 - 2.7e-12 46.9 33.7 1.6e-11 44.5 33.7 2.1 1 1 0 1 1 1 1 rRNA processing DOR PF14839.6 PIK48569.1 - 8.4 6.3 13.7 7.2 6.5 12.6 1.3 1 1 0 1 1 1 0 DOR family RAD51_interact PF15696.5 PIK48570.1 - 9.8e-13 48.0 0.2 9.8e-13 48.0 0.2 2.0 2 0 0 2 2 2 1 RAD51 interacting motif GRIP PF01465.20 PIK48571.1 - 0.0028 17.5 0.5 0.0028 17.5 0.5 3.1 3 0 0 3 3 3 1 GRIP domain Sulfotransfer_2 PF03567.14 PIK48572.1 - 9.7e-40 137.1 5.9 1.5e-39 136.4 5.9 1.3 1 0 0 1 1 1 1 Sulfotransferase family DUF3827 PF12877.7 PIK48573.1 - 4.4e-15 55.1 11.1 4.7e-13 48.4 7.1 3.3 2 1 0 2 2 2 2 Domain of unknown function (DUF3827) Shisa PF13908.6 PIK48573.1 - 0.032 14.5 0.2 0.032 14.5 0.2 5.1 5 2 0 5 5 5 0 Wnt and FGF inhibitory regulator rve PF00665.26 PIK48574.1 - 1.2e-22 80.3 0.0 8.1e-22 77.6 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48574.1 - 5.6e-20 71.2 0.3 1.2e-19 70.1 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK48574.1 - 0.017 15.4 1.4 0.029 14.6 0.3 2.0 2 0 0 2 2 2 0 H2C2 zinc finger rve_3 PF13683.6 PIK48574.1 - 0.072 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain MLVIN_C PF18697.1 PIK48574.1 - 0.1 12.7 0.3 0.2 11.7 0.3 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF2362 PF10154.9 PIK48575.1 - 1.9e-138 462.6 14.0 2.8e-138 462.0 14.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) CRM1_C PF08767.11 PIK48575.1 - 0.00049 19.4 1.8 0.00077 18.7 1.8 1.3 1 0 0 1 1 1 1 CRM1 C terminal ATG13 PF10033.9 PIK48576.1 - 1.3e-16 61.1 1.1 1.4e-07 31.5 0.1 3.3 1 1 1 2 2 2 2 Autophagy-related protein 13 S10_plectin PF03501.15 PIK48577.1 - 1.3e-20 73.3 0.5 5e-20 71.4 0.5 1.7 1 1 0 1 1 1 1 Plectin/S10 domain YhhN PF07947.14 PIK48578.1 - 2.9e-44 150.9 22.7 3.6e-44 150.6 22.7 1.1 1 0 0 1 1 1 1 YhhN family Lipase_GDSL_2 PF13472.6 PIK48581.1 - 1.6e-09 38.4 0.1 3.2e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK48581.1 - 9.2e-08 32.3 0.2 1.9e-07 31.3 0.2 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase OSK PF17182.4 PIK48581.1 - 0.00045 19.5 0.1 0.00045 19.5 0.1 1.7 2 1 0 2 2 2 1 OSK domain zf-CCHC PF00098.23 PIK48581.1 - 0.0028 17.7 2.2 0.0028 17.7 2.2 2.9 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK48581.1 - 0.47 10.2 15.3 1.6 8.5 2.6 2.6 2 0 0 2 2 2 0 Zinc knuckle TMEM154 PF15102.6 PIK48582.1 - 3.2e-05 23.9 0.4 6.4e-05 22.9 0.4 1.4 1 1 0 1 1 1 1 TMEM154 protein family ECSCR PF15820.5 PIK48582.1 - 0.023 14.5 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Orthoreo_P10 PF07204.11 PIK48582.1 - 0.054 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Trp_oprn_chp PF09534.10 PIK48582.1 - 0.084 12.7 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EphA2_TM PF14575.6 PIK48582.1 - 0.13 13.2 0.0 0.26 12.2 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ABC2_membrane_3 PF12698.7 PIK48583.1 - 3.5e-36 125.0 9.2 4.7e-36 124.6 9.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 PIK48583.1 - 2.1e-30 105.7 10.8 2.8e-29 102.1 10.8 2.2 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 PIK48583.1 - 1.4e-21 77.5 0.0 2.2e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_2 PF12679.7 PIK48583.1 - 2.6e-09 36.8 3.5 4e-09 36.2 3.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 PIK48583.1 - 3.3e-09 37.0 1.5 1.3e-06 28.4 0.1 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 PIK48583.1 - 0.0088 16.4 0.0 0.018 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Mannitol_dh PF01232.23 PIK48583.1 - 0.13 12.5 0.1 7.2 6.8 0.0 2.2 2 0 0 2 2 2 0 Mannitol dehydrogenase Rossmann domain Ig_3 PF13927.6 PIK48584.1 - 3.1e-14 53.3 0.0 8.1e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK48584.1 - 8.2e-14 51.4 0.0 1.4e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK48584.1 - 3.8e-09 36.8 0.0 8.2e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK48584.1 - 3.4e-07 30.3 0.1 7.5e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 PIK48584.1 - 0.00033 20.9 0.0 0.00076 19.8 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.17 PIK48584.1 - 0.00046 20.3 0.1 0.1 12.8 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin V-set domain DUF4577 PF15145.6 PIK48584.1 - 0.0023 17.9 0.1 0.0039 17.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) DIX PF00778.17 PIK48585.1 - 1.7e-32 111.1 0.1 3.3e-32 110.1 0.1 1.5 1 0 0 1 1 1 1 DIX domain WEMBL PF05701.11 PIK48585.1 - 7.5e-05 21.6 12.3 7.5e-05 21.6 12.3 2.0 1 1 1 2 2 2 1 Weak chloroplast movement under blue light ATG16 PF08614.11 PIK48585.1 - 0.002 18.4 36.4 0.0024 18.1 22.8 2.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 PIK48585.1 - 0.012 16.1 38.0 0.023 15.2 17.7 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region AAA_13 PF13166.6 PIK48585.1 - 0.18 10.4 21.8 0.95 8.0 20.6 1.9 1 1 1 2 2 2 0 AAA domain GAS PF13851.6 PIK48585.1 - 0.3 10.4 37.5 1.4 8.3 9.3 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 PIK48585.1 - 0.66 10.4 33.0 0.57 10.6 7.1 2.4 1 1 1 2 2 2 0 Fez1 Phage_tail_APC PF16778.5 PIK48585.1 - 1.1 9.2 3.8 0.85 9.5 1.2 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Filament PF00038.21 PIK48585.1 - 1.3 8.5 32.6 79 2.7 32.6 3.0 1 1 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.11 PIK48585.1 - 1.7 7.4 35.8 2.1 7.2 5.7 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Tup_N PF08581.10 PIK48585.1 - 1.9 8.8 29.0 2 8.8 5.0 3.6 3 0 0 3 3 3 0 Tup N-terminal DUF1664 PF07889.12 PIK48585.1 - 2.4 8.2 19.7 2.8 8.0 6.1 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 PIK48585.1 - 6.6 6.9 31.8 6.1 7.0 22.8 3.0 1 1 2 3 3 3 0 Tropomyosin like Nup54 PF13874.6 PIK48585.1 - 8.1 6.6 28.1 2.4 8.3 5.8 2.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 RRF_GI PF12614.8 PIK48585.1 - 8.7 6.5 10.0 1.9 8.7 4.1 2.4 1 1 1 2 2 2 0 Ribosome recycling factor CH PF00307.31 PIK48586.1 - 1.9e-10 40.9 0.0 2.5e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK48586.1 - 1.4e-05 24.8 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 PIK48586.1 - 0.0083 16.2 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 CH-like domain in sperm protein Init_tRNA_PT PF04179.12 PIK48586.1 - 0.019 15.3 0.0 0.028 14.7 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain PDDEXK_1 PF12705.7 PIK48586.1 - 0.037 13.9 0.1 0.055 13.4 0.1 1.2 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Lectin_C PF00059.21 PIK48587.1 - 2.7e-18 66.7 1.4 3.1e-18 66.5 1.4 1.0 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK48588.1 - 8.9e-20 71.4 2.8 1e-19 71.2 2.8 1.0 1 0 0 1 1 1 1 Lectin C-type domain PAPS_reduct PF01507.19 PIK48588.1 - 0.097 12.7 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family RVT_1 PF00078.27 PIK48589.1 - 4.8e-35 121.1 0.1 1.3e-34 119.7 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AMA-1 PF02430.15 PIK48591.1 - 0.019 13.9 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Apical membrane antigen 1 HEAT PF02985.22 PIK48592.1 - 9.4e-32 106.3 16.6 0.0011 19.0 0.0 10.7 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.6 PIK48592.1 - 5.7e-31 106.7 8.5 1.8e-12 47.5 0.0 6.6 2 2 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 PIK48592.1 - 2.5e-11 43.8 8.2 0.0023 18.4 0.1 6.3 6 1 1 7 7 7 3 HEAT-like repeat Cnd1 PF12717.7 PIK48592.1 - 5.9e-11 42.7 1.9 0.0058 16.7 0.1 5.1 1 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK48592.1 - 2.8e-09 37.4 0.3 0.087 13.4 0.0 6.1 3 1 5 8 8 8 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 PIK48592.1 - 2e-08 33.3 2.1 0.0073 14.9 0.0 3.4 2 1 1 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.8 PIK48592.1 - 3.8e-05 23.4 0.6 0.023 14.3 0.1 4.2 2 2 1 4 4 4 2 CLASP N terminal TAF6_C PF07571.13 PIK48592.1 - 7.2e-05 23.0 0.2 1.6 9.1 0.0 4.0 4 1 1 5 5 4 2 TAF6 C-terminal HEAT repeat domain DRIM PF07539.12 PIK48592.1 - 0.0011 17.3 1.3 0.86 7.8 0.1 3.4 1 1 2 3 3 3 2 Down-regulated in metastasis RTP1_C1 PF10363.9 PIK48592.1 - 0.0053 16.9 1.8 1.7 8.9 0.1 4.6 5 1 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 M11L PF11099.8 PIK48592.1 - 0.0059 16.9 0.2 0.031 14.6 0.0 2.3 2 1 1 3 3 3 1 Apoptosis regulator M11L like HEAT_PBS PF03130.16 PIK48592.1 - 0.014 16.0 0.3 8.4 7.4 0.0 4.2 4 0 0 4 4 2 0 PBS lyase HEAT-like repeat IFRD PF05004.13 PIK48592.1 - 0.015 14.4 0.6 0.076 12.1 0.1 2.3 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TED_complement PF07678.14 PIK48593.1 - 1.8e-92 309.7 0.0 2.6e-92 309.2 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 PIK48593.1 - 4.5e-25 87.3 0.0 1.7e-24 85.5 0.0 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 PIK48593.1 - 6.7e-24 84.8 2.6 7.1e-23 81.5 0.0 3.6 5 0 0 5 5 5 1 Alpha-2-macroglobulin bait region domain MG3 PF17791.1 PIK48593.1 - 2.1e-18 66.3 0.1 4.7e-17 62.0 0.0 3.0 2 0 0 2 2 2 1 Macroglobulin domain MG3 A2M_recep PF07677.14 PIK48593.1 - 6.5e-13 49.2 0.1 2.4e-12 47.4 0.1 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG4 PF17789.1 PIK48593.1 - 6.4e-09 35.9 0.1 3.4e-08 33.5 0.0 2.2 2 0 0 2 2 2 1 Macroglobulin domain MG4 SVA PF05326.11 PIK48593.1 - 3.2e-05 23.9 0.0 8.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) MG2 PF01835.19 PIK48593.1 - 0.02 15.3 0.0 0.073 13.5 0.0 1.9 1 0 0 1 1 1 0 MG2 domain RRM_1 PF00076.22 PIK48594.1 - 1.3e-18 66.6 0.1 2.8e-18 65.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK48594.1 - 7.7e-06 25.9 0.2 7.7e-06 25.9 0.2 1.8 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.6 PIK48594.1 - 0.00016 21.2 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK48594.1 - 0.061 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif MTS PF05175.14 PIK48595.1 - 0.018 14.6 0.1 0.024 14.2 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RVT_2 PF07727.14 PIK48596.1 - 6.6e-38 130.7 0.0 7.4e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Homeodomain PF00046.29 PIK48598.1 - 4.5e-19 68.0 1.4 1.2e-18 66.6 1.4 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK48598.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain Cadherin-like PF12733.7 PIK48599.1 - 1.2e-05 25.7 0.0 3.4e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Cadherin-like beta sandwich domain TRAP-delta PF05404.12 PIK48600.1 - 6e-62 207.9 0.0 7.2e-62 207.7 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) FHA PF00498.26 PIK48601.1 - 4e-18 65.5 0.0 1.3e-17 63.9 0.0 2.0 1 0 0 1 1 1 1 FHA domain Golgin_A5 PF09787.9 PIK48601.1 - 0.0089 15.5 16.5 0.0089 15.5 16.5 6.2 2 2 3 6 6 6 1 Golgin subfamily A member 5 Yop-YscD_cpl PF16697.5 PIK48601.1 - 0.02 15.2 0.0 0.13 12.6 0.0 2.4 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain IFRD PF05004.13 PIK48602.1 - 1e-95 320.4 7.2 1.4e-95 320.0 7.2 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 PIK48602.1 - 1.5e-16 60.7 6.6 3.9e-16 59.4 0.1 2.9 3 0 0 3 3 3 1 Interferon-related protein conserved region PALP PF00291.25 PIK48603.1 - 1.1e-65 221.9 0.1 1.4e-65 221.7 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Abhydrolase_1 PF00561.20 PIK48604.1 - 2.8e-26 92.7 0.9 8.7e-18 64.9 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK48604.1 - 2.8e-18 67.3 0.0 6.6e-18 66.1 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK48604.1 - 4.8e-12 45.7 0.6 8.8e-07 28.4 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 PIK48604.1 - 0.016 14.8 0.7 0.082 12.5 0.7 2.0 1 1 0 1 1 1 0 Putative esterase Palm_thioest PF02089.15 PIK48604.1 - 0.017 14.9 0.0 0.076 12.8 0.0 1.8 2 0 0 2 2 2 0 Palmitoyl protein thioesterase TSP_1 PF00090.19 PIK48606.1 - 4.8e-12 45.9 9.7 4.8e-12 45.9 9.7 3.4 3 1 0 3 3 3 1 Thrombospondin type 1 domain Hid1 PF12722.7 PIK48607.1 - 2 6.4 6.6 2.4 6.2 6.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.12 PIK48607.1 - 3.2 5.8 9.1 3.9 5.6 9.1 1.0 1 0 0 1 1 1 0 Nop14-like family RhlB PF12300.8 PIK48607.1 - 5 7.2 15.2 0.43 10.7 9.0 2.0 1 1 1 2 2 2 0 ATP-dependent RNA helicase RhlB UCH PF00443.29 PIK48608.1 - 8.4e-58 195.9 0.1 8.4e-58 195.9 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK48608.1 - 9.6e-15 55.0 1.3 9.9e-09 35.2 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-MYND PF01753.18 PIK48608.1 - 2.7e-08 33.8 18.4 2.7e-08 33.8 18.4 3.1 4 0 0 4 4 4 1 MYND finger CS PF04969.16 PIK48608.1 - 6.9e-07 30.2 1.4 6.9e-07 30.2 1.4 2.0 2 0 0 2 2 2 1 CS domain zf-C6H2 PF15801.5 PIK48608.1 - 8 6.9 28.4 2.3 8.6 15.1 3.7 4 0 0 4 4 4 0 zf-MYND-like zinc finger, mRNA-binding C2 PF00168.30 PIK48609.1 - 2.9e-12 46.8 0.0 9.7e-12 45.1 0.0 1.8 1 1 0 1 1 1 1 C2 domain HECW1_helix PF18436.1 PIK48610.1 - 1.9e-32 111.2 2.6 4.5e-30 103.6 1.1 2.7 2 0 0 2 2 2 2 Helical box domain of E3 ubiquitin-protein ligase HECW1 HECT PF00632.25 PIK48610.1 - 4.3e-21 75.7 0.0 6.5e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 PIK48610.1 - 4.5e-19 68.2 1.3 6.9e-09 35.6 0.4 2.5 2 0 0 2 2 2 2 WW domain HECT PF00632.25 PIK48611.1 - 2.5e-50 171.7 0.0 2.8e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HAGH_C PF16123.5 PIK48612.1 - 8.4e-22 77.5 0.0 1.5e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 PIK48612.1 - 9.7e-12 45.3 0.7 3.8e-11 43.4 0.7 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK48612.1 - 3.4e-05 23.5 0.0 4.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK48612.1 - 0.0022 17.9 0.1 0.019 14.9 0.1 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Pkinase PF00069.25 PIK48613.1 - 3.4e-29 102.0 0.0 5.1e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48613.1 - 1.1e-20 74.0 0.0 1.6e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK48613.1 - 9.5e-05 22.4 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK48613.1 - 0.012 14.5 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 PIK48613.1 - 0.031 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK48613.1 - 0.089 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 PIK48613.1 - 0.12 11.6 0.0 0.26 10.6 0.0 1.4 1 1 0 1 1 1 0 Kinase-like AAA_22 PF13401.6 PIK48615.1 - 0.0003 21.1 0.9 0.64 10.3 0.0 3.3 3 0 0 3 3 3 2 AAA domain UPF0102 PF02021.17 PIK48615.1 - 0.015 15.5 0.0 0.24 11.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0102 NERD PF08378.11 PIK48615.1 - 0.019 15.4 0.0 0.048 14.1 0.0 1.7 1 0 0 1 1 1 0 Nuclease-related domain DUF2075 PF09848.9 PIK48615.1 - 0.027 13.7 0.3 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF4143 PF13635.6 PIK48615.1 - 0.041 14.0 0.0 0.099 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4143) HLH PF00010.26 PIK48616.1 - 4.4e-20 71.4 0.2 1.2e-19 69.9 0.2 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SH2_2 PF14633.6 PIK48618.1 - 0.13 11.6 0.9 2.2 7.6 0.2 2.2 2 0 0 2 2 2 0 SH2 domain CD20 PF04103.15 PIK48619.1 - 1.8e-06 28.1 6.8 2.4e-06 27.7 6.8 1.2 1 0 0 1 1 1 1 CD20-like family PSII PF00421.19 PIK48619.1 - 7.6e-05 21.6 1.4 8.3e-05 21.5 1.4 1.2 1 0 0 1 1 1 1 Photosystem II protein DUF2417 PF10329.9 PIK48619.1 - 0.048 13.1 1.9 0.062 12.7 1.9 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Tetraspanin PF00335.20 PIK48619.1 - 0.14 11.9 8.1 0.15 11.7 7.1 1.3 1 1 0 1 1 1 0 Tetraspanin family DUF308 PF03729.13 PIK48619.1 - 1.3 9.4 10.3 12 6.3 10.3 2.2 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) DUF5353 PF17304.2 PIK48619.1 - 3.5 7.4 6.3 4.3 7.2 0.4 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5353) Reo_sigmaC_M PF17750.1 PIK48620.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein triple beta spiral CD20 PF04103.15 PIK48620.1 - 0.39 10.8 12.8 0.86 9.7 12.8 1.6 1 1 0 1 1 1 0 CD20-like family PFK PF00365.20 PIK48621.1 - 5.7e-179 593.5 1.1 8.5e-104 346.8 0.9 2.0 2 0 0 2 2 2 2 Phosphofructokinase Fam20C PF06702.12 PIK48622.1 - 0.00019 21.3 0.1 0.00032 20.6 0.1 1.3 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK48622.1 - 0.00019 20.4 0.0 0.00027 19.9 0.0 1.3 1 0 0 1 1 1 1 FAM198 protein RhoGEF PF00621.20 PIK48623.1 - 9.8e-31 107.4 0.1 6.4e-30 104.7 0.0 2.2 2 0 0 2 2 2 1 RhoGEF domain PTCB-BRCT PF12738.7 PIK48623.1 - 8.7e-27 92.9 0.6 5.9e-20 71.0 0.1 2.8 3 0 0 3 3 3 2 twin BRCT domain BRCT PF00533.26 PIK48623.1 - 2.6e-15 56.6 0.8 2.9e-08 34.0 0.1 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK48623.1 - 5.2e-06 26.8 0.1 0.049 14.1 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 PIK48623.1 - 0.011 16.0 0.6 2.2 8.6 0.1 2.6 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain HTH_Tnp_Mu_2 PF09039.11 PIK48623.1 - 0.09 12.9 0.0 0.3 11.2 0.0 1.9 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain DUF4499 PF14934.6 PIK48624.1 - 4.8e-24 84.5 1.7 6e-24 84.2 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) TCTP PF00838.17 PIK48625.1 - 2.9e-29 102.6 0.7 3.7e-29 102.2 0.7 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein HD_3 PF13023.6 PIK48625.1 - 0.06 13.3 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 HD domain Pneumo_ncap PF03246.13 PIK48625.1 - 0.1 11.3 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein YlbE PF14003.6 PIK48625.1 - 0.12 12.9 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 YlbE-like protein Col_cuticle_N PF01484.17 PIK48626.1 - 0.94 9.6 0.0 0.94 9.6 0.0 3.4 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain IF4E PF01652.18 PIK48627.1 - 1.5e-31 109.3 0.2 1.2e-27 96.7 0.1 2.1 1 1 1 2 2 2 2 Eukaryotic initiation factor 4E Hormone_recep PF00104.30 PIK48628.1 - 1.3e-19 70.6 0.0 1.5e-19 70.4 0.0 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Thymidylate_kin PF02223.17 PIK48629.1 - 2.3e-34 118.7 0.0 2.8e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA PF00004.29 PIK48630.1 - 8.8e-60 200.9 0.0 6.2e-45 152.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 PIK48630.1 - 2.8e-27 95.0 0.3 7.7e-27 93.5 0.3 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal PEX-2N PF09263.10 PIK48630.1 - 1.7e-16 60.3 0.1 5.9e-16 58.6 0.1 2.0 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 PIK48630.1 - 9e-10 38.2 0.0 5.9e-06 26.0 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 PIK48630.1 - 1.8e-08 35.0 5.7 0.0027 18.1 0.0 4.2 2 2 2 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 PIK48630.1 - 8.2e-08 32.3 0.0 0.0038 17.2 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 PIK48630.1 - 1.3e-07 31.5 0.0 0.00044 20.0 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK48630.1 - 6.3e-07 29.7 2.8 0.011 16.0 0.1 4.3 2 2 2 4 4 4 2 AAA domain TIP49 PF06068.13 PIK48630.1 - 8.7e-07 28.5 0.0 0.028 13.6 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 PIK48630.1 - 9.1e-07 29.1 0.1 0.023 14.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 PIK48630.1 - 2.8e-06 27.7 0.0 0.0057 17.0 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 PIK48630.1 - 7.3e-06 26.6 0.0 0.15 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 PIK48630.1 - 1.3e-05 25.4 0.0 0.14 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) TsaE PF02367.17 PIK48630.1 - 0.00014 21.9 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 PIK48630.1 - 0.00026 21.0 0.0 0.09 12.8 0.0 2.9 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.21 PIK48630.1 - 0.00035 20.0 0.1 0.89 8.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 PIK48630.1 - 0.00064 19.5 0.2 0.32 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 PIK48630.1 - 0.00091 19.8 0.0 0.027 15.0 0.0 2.6 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 PIK48630.1 - 0.00091 19.2 2.3 0.038 13.9 0.1 3.7 3 1 0 3 3 3 1 NACHT domain IstB_IS21 PF01695.17 PIK48630.1 - 0.0011 18.8 0.0 0.88 9.3 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 PIK48630.1 - 0.0015 18.2 0.1 5.3 6.6 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 PIK48630.1 - 0.0021 17.6 0.0 0.57 9.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 PIK48630.1 - 0.0039 17.3 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Rad17 PF03215.15 PIK48630.1 - 0.0045 16.9 0.0 0.36 10.7 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_29 PF13555.6 PIK48630.1 - 0.0069 16.1 0.3 0.35 10.6 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 PIK48630.1 - 0.01 15.0 0.0 0.06 12.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 PIK48630.1 - 0.015 15.8 0.2 0.071 13.6 0.1 2.2 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 PIK48630.1 - 0.016 15.1 0.2 0.49 10.3 0.0 2.7 3 0 0 3 3 3 0 NTPase cNMPbd_u2 PF16643.5 PIK48630.1 - 0.018 15.5 0.6 0.058 13.9 0.6 1.9 1 0 0 1 1 1 0 Unstructured region on cNMP-binding protein Sigma54_activat PF00158.26 PIK48630.1 - 0.04 13.6 0.1 2.9 7.6 0.0 2.7 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 PIK48630.1 - 0.042 13.1 0.0 0.9 8.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.22 PIK48630.1 - 0.044 13.0 0.0 0.82 8.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Bac_DnaA PF00308.18 PIK48630.1 - 0.068 13.0 0.0 0.52 10.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_17 PF13207.6 PIK48630.1 - 0.074 13.5 0.4 12 6.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 PIK48630.1 - 0.097 12.0 0.3 6.5 6.0 0.0 2.3 2 0 0 2 2 2 0 KaiC T2SSE PF00437.20 PIK48630.1 - 0.13 11.3 0.0 2.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein ATPase_2 PF01637.18 PIK48630.1 - 0.19 11.6 0.0 4.7 7.0 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 PIK48630.1 - 0.2 12.0 0.5 23 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ribosomal_L7Ae PF01248.26 PIK48631.1 - 0.0012 18.6 0.2 0.0024 17.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 PIK48631.1 - 0.016 15.3 0.4 0.037 14.1 0.3 1.7 2 0 0 2 2 2 0 RNase P subunit Pop3 Sybindin PF04099.12 PIK48632.1 - 6.1e-42 142.9 0.7 6.8e-42 142.8 0.7 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 PIK48632.1 - 0.00079 19.6 0.4 0.0011 19.1 0.4 1.4 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Filamin PF00630.19 PIK48633.1 - 4.7e-59 197.6 1.8 1.8e-15 57.6 0.0 6.5 6 0 0 6 6 6 6 Filamin/ABP280 repeat CH PF00307.31 PIK48633.1 - 8.9e-35 119.2 0.0 7.3e-15 55.1 0.0 3.8 4 0 0 4 4 4 3 Calponin homology (CH) domain CarboxypepD_reg PF13620.6 PIK48633.1 - 1.6e-06 28.3 1.8 0.094 13.0 0.3 4.6 5 0 0 5 5 5 2 Carboxypeptidase regulatory-like domain CAMSAP_CH PF11971.8 PIK48633.1 - 1.5e-05 24.7 0.0 0.0053 16.6 0.0 2.9 3 0 0 3 3 3 1 CAMSAP CH domain CarbopepD_reg_2 PF13715.6 PIK48633.1 - 0.00038 20.4 0.5 0.9 9.6 0.0 4.5 4 0 0 4 4 4 1 CarboxypepD_reg-like domain CH_2 PF06294.11 PIK48633.1 - 0.0012 18.9 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 2 CH-like domain in sperm protein Y_Y_Y PF07495.13 PIK48633.1 - 0.03 14.3 0.1 0.48 10.4 0.0 2.9 4 0 0 4 4 4 0 Y_Y_Y domain DUF5060 PF16586.5 PIK48633.1 - 0.036 14.4 0.1 12 6.4 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) He_PIG PF05345.12 PIK48633.1 - 0.13 12.5 3.4 5.3 7.3 0.5 4.4 4 0 0 4 4 4 0 Putative Ig domain CBM_35 PF16990.5 PIK48633.1 - 0.19 12.0 0.8 32 4.8 0.0 3.9 4 1 0 4 4 4 0 Carbohydrate binding module (family 35) Big_3 PF07523.12 PIK48633.1 - 2.3 8.6 5.0 37 4.7 0.1 4.4 4 1 1 5 5 5 0 Bacterial Ig-like domain (group 3) Big_9 PF17963.1 PIK48633.1 - 2.3 9.0 7.1 6.9 7.5 0.3 3.8 3 1 0 3 3 3 0 Bacterial Ig domain Ephrin_rec_like PF07699.13 PIK48634.1 - 0.016 15.0 3.8 0.016 15.0 3.8 8.4 4 4 3 7 7 7 0 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 PIK48635.1 - 3.5e-05 23.5 26.6 0.00073 19.3 6.9 16.3 7 7 12 19 19 19 13 Putative ephrin-receptor like APC_r PF05923.12 PIK48635.1 - 0.039 13.7 0.2 0.17 11.7 0.2 2.3 1 0 0 1 1 1 0 APC repeat Ephrin_rec_like PF07699.13 PIK48636.1 - 0.00043 20.0 3.7 0.00043 20.0 3.7 9.1 6 2 3 10 10 10 5 Putative ephrin-receptor like ADIP PF11559.8 PIK48637.1 - 0.0021 18.2 14.5 0.0021 18.2 14.5 4.0 1 1 3 4 4 4 1 Afadin- and alpha -actinin-Binding DUF724 PF05266.14 PIK48637.1 - 0.013 15.3 63.0 0.15 11.9 13.0 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF724) CEP209_CC5 PF16574.5 PIK48637.1 - 0.017 15.3 10.0 0.017 15.3 10.0 4.8 2 1 2 4 4 4 0 Coiled-coil region of centrosome protein CE290 Fez1 PF06818.15 PIK48637.1 - 0.1 13.0 58.5 0.031 14.7 27.4 2.6 1 1 1 2 2 2 0 Fez1 FAM76 PF16046.5 PIK48637.1 - 0.11 11.9 58.4 5.4 6.3 5.8 4.0 1 1 2 3 3 3 0 FAM76 protein USP8_interact PF08941.10 PIK48637.1 - 6 6.6 41.0 5.3 6.8 0.9 5.2 2 2 3 5 5 5 0 USP8 interacting ATG16 PF08614.11 PIK48637.1 - 8.5 6.5 53.0 1.5 9.0 11.5 4.0 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) WHEP-TRS PF00458.20 PIK48637.1 - 8.9 6.6 28.4 2.1 8.6 0.6 5.2 4 1 2 6 6 6 0 WHEP-TRS domain HAUS-augmin3 PF14932.6 PIK48639.1 - 0.0068 16.0 1.3 0.0068 16.0 1.3 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 Val_tRNA-synt_C PF10458.9 PIK48639.1 - 0.0076 16.5 2.2 0.57 10.5 0.4 2.8 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm ANAPC4_WD40 PF12894.7 PIK48639.1 - 0.059 13.7 0.6 3.7 7.9 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Spectrin PF00435.21 PIK48639.1 - 0.097 13.2 7.3 0.032 14.7 4.4 1.7 2 0 0 2 2 2 0 Spectrin repeat CP12 PF02672.15 PIK48639.1 - 0.13 13.1 2.0 0.3 11.9 0.5 2.1 2 0 0 2 2 2 0 CP12 domain Cep57_MT_bd PF06657.13 PIK48639.1 - 0.26 11.8 4.3 1.1 9.7 0.3 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3251 PF11622.8 PIK48639.1 - 0.34 10.5 3.5 0.17 11.5 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3251) Matrilin_ccoil PF10393.9 PIK48639.1 - 0.35 10.8 4.2 2.6 8.0 0.7 3.2 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin APG6_N PF17675.1 PIK48639.1 - 0.35 11.4 8.7 0.17 12.4 4.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Spc24 PF08286.11 PIK48639.1 - 0.39 11.0 6.6 1.1 9.5 6.6 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CENP-F_leu_zip PF10473.9 PIK48639.1 - 0.47 10.5 11.3 0.049 13.7 6.5 1.8 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4140 PF13600.6 PIK48639.1 - 0.61 10.5 3.9 0.39 11.2 1.2 2.0 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4200 PF13863.6 PIK48639.1 - 0.73 10.2 15.0 0.61 10.5 7.9 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DegS PF05384.11 PIK48639.1 - 0.9 9.0 11.3 0.027 14.0 2.3 2.4 3 0 0 3 3 3 0 Sensor protein DegS BRE1 PF08647.11 PIK48639.1 - 1.4 9.0 12.9 0.75 9.9 6.6 3.0 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase FlaC_arch PF05377.11 PIK48639.1 - 1.4 9.3 9.0 0.33 11.4 2.8 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Flagellin_N PF00669.20 PIK48639.1 - 1.8 8.7 8.5 1.5 8.9 2.2 2.9 2 1 1 3 3 3 0 Bacterial flagellin N-terminal helical region DUF641 PF04859.12 PIK48639.1 - 2.7 8.4 7.1 0.54 10.6 3.3 1.8 2 1 0 2 2 1 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 PIK48639.1 - 2.7 8.5 8.2 39 4.8 8.2 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 PIK48639.1 - 3.2 8.0 9.5 0.84 9.9 3.6 2.9 2 1 1 3 3 3 0 Haemolysin XhlA DUF1664 PF07889.12 PIK48639.1 - 4.5 7.3 9.8 1.8 8.6 6.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.6 PIK48639.1 - 4.9 7.6 11.7 2.3 8.6 5.0 2.5 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 EamA PF00892.20 PIK48640.1 - 1.4e-14 54.4 13.8 1.4e-14 54.4 13.8 2.1 2 0 0 2 2 2 1 EamA-like transporter family CENP-C_C PF11699.8 PIK48640.1 - 0.087 13.1 0.0 0.96 9.7 0.0 2.3 2 0 0 2 2 2 0 Mif2/CENP-C like Pkinase_Tyr PF07714.17 PIK48641.1 - 1.6e-13 50.6 0.0 1.9e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48641.1 - 3e-07 30.1 0.0 4.8e-07 29.4 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48642.1 - 8.6e-16 58.0 0.1 9e-16 57.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48642.1 - 2e-08 34.0 0.0 2.3e-08 33.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48643.1 - 1.3e-08 34.4 0.0 1.7e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48643.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.4 1 1 0 1 1 1 0 Protein kinase domain RVT_1 PF00078.27 PIK48644.1 - 1.4e-19 70.5 0.0 2.1e-19 69.9 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sipho_Gp157 PF05565.11 PIK48645.1 - 0.0019 18.2 3.9 0.0028 17.7 3.9 1.2 1 0 0 1 1 1 1 Siphovirus Gp157 YabA PF06156.13 PIK48645.1 - 0.0031 18.1 2.2 0.0048 17.5 1.8 1.5 1 1 0 1 1 1 1 Initiation control protein YabA GAS PF13851.6 PIK48645.1 - 0.011 15.1 3.7 0.017 14.5 3.7 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HD_2 PF12917.7 PIK48645.1 - 0.011 15.5 0.8 0.018 14.8 0.8 1.3 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Wtap PF17098.5 PIK48645.1 - 0.024 14.6 2.2 0.037 14.0 2.2 1.3 1 1 0 1 1 1 0 WTAP/Mum2p family Herpes_UL6 PF01763.16 PIK48645.1 - 0.04 12.4 0.6 0.043 12.3 0.6 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF2408 PF10303.9 PIK48645.1 - 0.05 14.2 1.5 0.086 13.4 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Med9 PF07544.13 PIK48645.1 - 0.054 13.6 5.0 0.17 12.0 4.9 1.9 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Seryl_tRNA_N PF02403.22 PIK48645.1 - 0.061 13.6 7.6 0.034 14.4 5.9 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 PIK48645.1 - 0.1 12.6 3.4 0.16 12.0 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PorB PF11565.8 PIK48645.1 - 0.11 12.9 0.2 0.56 10.6 0.0 1.9 1 1 1 2 2 2 0 Alpha helical Porin B Swi5 PF07061.11 PIK48645.1 - 0.11 12.5 2.8 0.2 11.7 2.8 1.4 1 0 0 1 1 1 0 Swi5 CENP-F_leu_zip PF10473.9 PIK48645.1 - 0.25 11.4 7.3 0.34 10.9 6.5 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.6 PIK48645.1 - 0.3 11.5 5.6 0.42 11.0 4.6 1.7 1 1 1 2 2 2 0 Syntaxin-like protein DivIC PF04977.15 PIK48645.1 - 0.37 10.6 4.4 0.23 11.2 0.5 2.4 1 1 2 3 3 3 0 Septum formation initiator DUF724 PF05266.14 PIK48645.1 - 0.63 9.8 4.7 0.79 9.5 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 PIK48645.1 - 1.2 9.2 6.4 1.5 8.9 6.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Glyco_transf_10 PF00852.19 PIK48646.1 - 3.7e-35 121.2 0.1 5.3e-35 120.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK48646.1 - 4.9e-05 23.8 0.1 0.00017 22.0 0.0 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK48647.1 - 1e-48 165.4 0.0 1.5e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK48647.1 - 1.7e-16 60.7 0.2 1e-15 58.1 0.0 2.3 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK48648.1 - 1.2e-51 175.0 0.1 1.8e-51 174.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK48648.1 - 2.5e-13 50.4 1.7 4.5e-13 49.6 0.8 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal ROS_MUCR PF05443.11 PIK48648.1 - 0.18 11.8 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein SSF PF00474.17 PIK48650.1 - 5.1e-61 206.7 3.7 6.7e-61 206.4 3.7 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family CRCB PF02537.15 PIK48650.1 - 0.18 12.1 3.3 0.1 12.9 0.5 2.1 2 1 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) PAN_3 PF08277.12 PIK48650.1 - 0.21 11.4 2.3 0.45 10.4 0.3 2.2 2 0 0 2 2 2 0 PAN-like domain PAN_1 PF00024.26 PIK48650.1 - 0.25 11.4 3.3 0.37 10.8 0.4 2.1 2 0 0 2 2 2 0 PAN domain PAN_4 PF14295.6 PIK48650.1 - 3.5 7.6 7.4 0.19 11.6 0.4 2.3 3 0 0 3 3 3 0 PAN domain Toxin_2 PF00451.19 PIK48650.1 - 8.5 6.8 9.9 0.12 12.8 2.2 1.9 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 HSCB_C PF07743.13 PIK48651.1 - 1.9e-16 60.3 2.2 1.9e-16 60.3 2.2 1.7 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 PIK48651.1 - 0.00015 21.8 0.5 0.00047 20.2 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain DUF4795 PF16043.5 PIK48651.1 - 0.034 13.8 1.1 0.069 12.7 1.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF5478 PF17572.2 PIK48651.1 - 0.037 14.1 0.4 0.085 13.0 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5478) OrfB_Zn_ribbon PF07282.11 PIK48651.1 - 0.27 11.2 2.5 0.45 10.5 1.7 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain HscB_4_cys PF18256.1 PIK48651.1 - 9.5 6.1 8.2 21 5.1 8.2 1.6 1 1 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif TFIIA PF03153.13 PIK48653.1 - 0.003 17.6 8.5 0.003 17.6 8.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 PIK48653.1 - 0.011 15.4 13.1 0.012 15.3 13.1 1.1 1 0 0 1 1 1 0 Spt20 family Hydin_ADK PF17213.3 PIK48653.1 - 0.013 15.8 0.5 0.015 15.6 0.5 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain EIF4E-T PF10477.9 PIK48653.1 - 0.02 13.7 5.6 0.02 13.7 5.6 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2722 PF10846.8 PIK48653.1 - 0.025 13.6 11.2 0.028 13.4 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 PIK48653.1 - 0.032 15.2 0.7 0.043 14.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Suf PF05843.14 PIK48653.1 - 0.13 12.3 4.2 0.13 12.2 4.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) IER PF05760.12 PIK48653.1 - 0.18 12.1 6.4 0.22 11.8 6.4 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) Androgen_recep PF02166.16 PIK48653.1 - 0.73 8.6 12.8 0.82 8.4 12.8 1.2 1 0 0 1 1 1 0 Androgen receptor APC_u14 PF16635.5 PIK48653.1 - 2.1 8.9 9.7 3.5 8.2 9.7 1.3 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr Roughex PF06020.11 PIK48653.1 - 3.7 6.6 6.4 4.5 6.3 6.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein BRD4_CDT PF17105.5 PIK48655.1 - 2.8 7.6 6.0 0.39 10.4 0.9 2.2 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 MID_MedPIWI PF18296.1 PIK48656.1 - 8.3e-35 120.7 0.0 1.7e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 MID domain of medPIWI Med13_C PF06333.12 PIK48657.1 - 1.5e-51 175.6 1.0 1.8e-51 175.4 1.0 1.1 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain V-set PF07686.17 PIK48658.1 - 1.9e-08 34.4 2.4 0.0016 18.6 0.1 3.8 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK48658.1 - 2.9e-08 34.2 0.7 0.0012 19.4 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK48658.1 - 4e-05 23.9 3.5 0.0099 16.2 0.1 4.1 3 2 2 5 5 5 1 Immunoglobulin domain ig PF00047.25 PIK48658.1 - 0.00016 21.7 0.8 0.0083 16.3 0.0 3.3 4 0 0 4 4 4 1 Immunoglobulin domain Ig_5 PF16681.5 PIK48658.1 - 0.36 11.3 4.9 0.16 12.4 0.6 2.6 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ANF_receptor PF01094.28 PIK48659.1 - 4.9e-06 25.9 0.0 7.4e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lectin_C PF00059.21 PIK48659.1 - 0.0059 17.3 1.5 0.013 16.2 1.5 1.6 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK48659.1 - 0.13 11.9 0.1 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like 7tm_3 PF00003.22 PIK48660.1 - 6.1e-18 65.4 10.0 6.1e-18 65.4 10.0 1.5 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 PIK48660.1 - 2.1e-05 23.8 0.0 3.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region PAP2_3 PF14378.6 PIK48660.1 - 0.0094 15.6 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 PAP2 superfamily TMEM101 PF15111.6 PIK48660.1 - 0.067 12.7 1.1 1.4 8.4 0.0 2.2 1 1 1 2 2 2 0 TMEM101 protein family Bac_rhodopsin PF01036.18 PIK48660.1 - 0.077 12.6 0.2 0.077 12.6 0.2 2.2 2 1 0 2 2 2 0 Bacteriorhodopsin-like protein COG6 PF06419.11 PIK48660.1 - 0.1 10.8 0.1 0.15 10.2 0.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Cnn_1N PF07989.11 PIK48660.1 - 0.12 12.5 0.4 0.22 11.7 0.4 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 MgtE PF01769.16 PIK48660.1 - 1.7 9.0 9.5 0.28 11.6 1.4 2.6 3 0 0 3 3 3 0 Divalent cation transporter ANF_receptor PF01094.28 PIK48661.1 - 5.8e-14 52.0 0.1 2.6e-09 36.7 0.0 2.0 1 1 1 2 2 2 2 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK48661.1 - 0.00012 21.9 0.0 0.0082 15.8 0.0 2.0 1 1 1 2 2 2 2 Periplasmic binding protein 7tm_3 PF00003.22 PIK48662.1 - 3.5e-06 26.9 26.7 0.0014 18.4 14.2 2.1 1 1 1 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR DUF4079 PF13301.6 PIK48662.1 - 0.33 11.1 2.7 0.49 10.5 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Oxidored_q3 PF00499.20 PIK48662.1 - 0.4 10.4 10.2 0.076 12.7 4.1 2.2 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 7tm_3 PF00003.22 PIK48663.1 - 3.3e-20 72.9 13.0 3.9e-20 72.6 13.0 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR BIRC6 PF12356.8 PIK48664.1 - 9.1e-46 155.5 1.5 1.8e-45 154.5 0.1 2.3 2 0 0 2 2 2 1 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.26 PIK48664.1 - 2.6e-26 91.9 0.0 6.3e-26 90.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK48664.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 UEV domain BIR PF00653.21 PIK48665.1 - 3.8e-10 40.3 1.6 5.5e-09 36.6 1.6 2.4 1 1 0 1 1 1 1 Inhibitor of Apoptosis domain DUF3589 PF12141.8 PIK48665.1 - 0.14 10.7 0.1 0.21 10.1 0.1 1.3 1 0 0 1 1 1 0 Beta-mannosyltransferases Inositol_P PF00459.25 PIK48666.1 - 1.9e-41 142.4 0.1 2.3e-41 142.1 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family TIR_2 PF13676.6 PIK48667.1 - 6.4e-21 75.2 0.0 1.7e-20 73.7 0.0 1.8 1 0 0 1 1 1 1 TIR domain SAM_3 PF18016.1 PIK48667.1 - 0.00017 21.3 0.1 0.00035 20.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK48667.1 - 0.039 14.4 0.2 0.092 13.2 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) LRR_8 PF13855.6 PIK48668.1 - 3.4e-33 113.2 48.5 5.1e-09 35.8 2.1 3.9 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK48668.1 - 1.7e-16 60.0 18.3 2.4e-05 24.6 0.9 4.4 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK48668.1 - 9.6e-06 25.5 21.9 3.4 8.6 0.3 7.3 6 1 1 7 7 7 4 Leucine Rich Repeat LRR_6 PF13516.6 PIK48668.1 - 0.018 15.0 24.8 1.1 9.5 0.2 6.8 7 0 0 7 7 7 0 Leucine Rich repeat LRR_5 PF13306.6 PIK48668.1 - 0.085 12.8 4.5 0.15 12.1 4.0 1.6 1 1 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) LRR_3 PF07725.12 PIK48668.1 - 0.35 10.8 3.5 9.8 6.2 0.4 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat Sugar_tr PF00083.24 PIK48669.1 - 5.3e-19 68.4 4.2 7e-19 68.0 4.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK48669.1 - 3.2e-14 52.6 14.1 2.3e-13 49.8 12.3 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily TPR_2 PF07719.17 PIK48669.1 - 0.043 13.9 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Peptidase_C13 PF01650.18 PIK48670.1 - 3.6e-96 321.6 0.0 5.7e-96 320.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family MoCF_biosynth PF00994.24 PIK48671.1 - 8.5e-14 51.4 0.2 8.6e-14 51.4 0.2 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain Pkinase PF00069.25 PIK48672.1 - 4.2e-35 121.4 0.0 8.7e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48672.1 - 1.2e-24 87.0 0.0 2.5e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Death PF00531.22 PIK48672.1 - 3.4e-22 78.4 0.2 9.8e-10 38.5 0.2 2.6 2 0 0 2 2 2 2 Death domain Mt_ATP-synt_B PF05405.14 PIK48672.1 - 0.016 14.9 0.1 0.037 13.7 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HTH_31 PF13560.6 PIK48672.1 - 0.098 13.0 0.0 25 5.3 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain Adap_comp_sub PF00928.21 PIK48673.1 - 1.9e-60 204.5 0.1 2.6e-60 204.0 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK48673.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Death PF00531.22 PIK48675.1 - 0.057 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Death domain Hydrolase_6 PF13344.6 PIK48676.1 - 3.7e-28 97.6 0.0 7.9e-28 96.5 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK48676.1 - 6.3e-19 67.8 0.0 1.1e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 PIK48676.1 - 1.4e-10 41.8 0.0 2.2e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK48676.1 - 1e-08 35.5 0.1 5.1e-06 26.7 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 PIK48676.1 - 0.078 12.6 0.0 0.32 10.6 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Avl9 PF09794.9 PIK48676.1 - 0.092 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Transport protein Avl9 A_deaminase PF00962.22 PIK48678.1 - 9.8e-07 28.4 0.0 1.2e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase APOBEC_C PF05240.14 PIK48678.1 - 0.036 14.0 0.2 0.064 13.2 0.2 1.4 1 1 0 1 1 1 0 APOBEC-like C-terminal domain APOBEC2 PF18772.1 PIK48678.1 - 0.096 12.7 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 ATP-synt_Eps PF04627.13 PIK48678.1 - 1 9.4 3.1 9.1 6.4 0.5 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain RIIa PF02197.17 PIK48679.1 - 0.002 17.7 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Rib_hydrolayse PF02267.17 PIK48680.1 - 3.3e-39 134.7 5.8 4.5e-39 134.3 5.8 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase GP17 PF17420.2 PIK48680.1 - 0.05 13.8 0.0 0.087 13.0 0.0 1.3 1 0 0 1 1 1 0 Superinfection exclusion gene product 17 DHHC PF01529.20 PIK48681.1 - 2.7e-30 105.2 14.1 2.7e-30 105.2 14.1 2.9 2 1 1 3 3 3 1 DHHC palmitoyltransferase Ank_5 PF13857.6 PIK48681.1 - 1e-19 70.3 1.3 1.7e-06 28.2 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK48681.1 - 3.1e-19 69.1 0.5 3.6e-09 37.0 0.1 4.4 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK48681.1 - 9e-17 61.4 0.1 2e-08 34.7 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 PIK48681.1 - 3.3e-15 55.8 0.3 0.0016 18.8 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 PIK48681.1 - 1.2e-14 52.9 0.4 0.011 16.1 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat TMEM100 PF16311.5 PIK48681.1 - 0.59 9.7 2.0 0.88 9.2 0.3 1.9 2 0 0 2 2 2 0 Transmembrane protein 100 KH_8 PF17903.1 PIK48682.1 - 2.4e-30 104.4 1.9 4.3e-30 103.6 0.0 2.4 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 PIK48682.1 - 0.00083 19.1 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 KH domain FERM_F2 PF18377.1 PIK48682.1 - 0.1 12.5 0.2 1.9 8.4 0.1 2.4 2 1 0 2 2 2 0 FERM F2 acyl-CoA binding protein-like domain KH_4 PF13083.6 PIK48682.1 - 0.11 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 KH domain Rieske PF00355.26 PIK48683.1 - 3e-09 36.7 0.1 4.6e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 PIK48683.1 - 1.5e-06 28.1 0.0 2.5e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Bac_DNA_binding PF00216.21 PIK48683.1 - 0.039 14.2 0.2 0.058 13.6 0.2 1.3 1 0 0 1 1 1 0 Bacterial DNA-binding protein PDDEXK_1 PF12705.7 PIK48683.1 - 0.11 12.4 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily PHD PF00628.29 PIK48684.1 - 1.3e-11 44.2 9.9 1.3e-11 44.2 9.9 2.5 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 PIK48684.1 - 4.6e-10 39.7 23.8 1.5e-09 38.1 4.7 2.5 2 0 0 2 2 2 2 Ring finger domain zf-RING_UBOX PF13445.6 PIK48684.1 - 1.5e-06 28.1 5.7 1.5e-06 28.1 5.7 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK48684.1 - 2.2e-06 27.4 4.0 2.2e-06 27.4 4.0 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK48684.1 - 7.1e-06 25.8 5.2 7.1e-06 25.8 5.2 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK48684.1 - 1.3e-05 25.1 2.7 1.3e-05 25.1 2.7 2.9 2 1 1 3 3 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK48684.1 - 3.6e-05 23.5 3.9 3.6e-05 23.5 3.9 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK48684.1 - 0.0003 21.0 6.0 0.0003 21.0 6.0 3.1 2 2 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 PIK48684.1 - 0.00071 19.4 2.1 0.00071 19.4 2.1 3.7 2 2 1 3 3 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK48684.1 - 0.0019 18.3 3.1 0.0019 18.3 3.1 3.3 2 2 1 3 3 3 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 PIK48684.1 - 0.0038 16.8 1.9 0.0038 16.8 1.9 3.1 2 1 0 2 2 2 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 PIK48684.1 - 1.3 9.3 18.2 0.059 13.6 3.9 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain SpoIIIAH PF12685.7 PIK48684.1 - 2.3 8.0 9.7 0.68 9.7 3.5 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein zf-ANAPC11 PF12861.7 PIK48684.1 - 4.2 7.5 14.8 0.19 11.8 2.2 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pkinase_fungal PF17667.1 PIK48684.1 - 6.2 5.5 7.3 9.4 4.9 7.3 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ecl1 PF12855.7 PIK48686.1 - 2 9.5 16.1 0.79 10.9 13.8 1.5 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins 5_nucleotid_C PF02872.18 PIK48687.1 - 2.2e-45 154.7 0.0 2.8e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Glyco_hydro_36C PF16874.5 PIK48687.1 - 0.14 12.7 0.1 12 6.4 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 36 C-terminal domain Metallophos PF00149.28 PIK48688.1 - 5.7e-05 23.7 0.0 7.9e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RVT_1 PF00078.27 PIK48690.1 - 6.3e-17 61.8 0.0 1.3e-16 60.8 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_int_SAM_4 PF13495.6 PIK48691.1 - 0.026 15.0 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK48691.1 - 0.14 12.5 0.1 0.14 12.5 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 PIK48692.1 - 4.7e-23 81.9 0.0 7.8e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK48693.1 - 1.9e-20 73.2 0.2 3.4e-20 72.4 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK48693.1 - 9.3e-07 28.5 0.1 3.9e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-RING_UBOX PF13445.6 PIK48694.1 - 1.3e-07 31.5 6.8 1.3e-07 31.5 6.8 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK48694.1 - 2.7e-06 27.1 8.0 2.7e-06 27.1 8.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK48694.1 - 0.0002 21.5 4.3 0.0002 21.5 4.3 3.0 3 0 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.6 PIK48694.1 - 0.00038 20.7 8.6 0.00038 20.7 8.6 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK48694.1 - 0.00046 20.0 6.9 0.00046 20.0 6.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK48694.1 - 0.00067 19.5 8.8 0.00067 19.5 8.8 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK48694.1 - 0.0014 18.7 8.3 0.0014 18.7 8.3 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK48694.1 - 0.0067 16.4 8.4 0.0067 16.4 8.4 2.7 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK48694.1 - 0.022 14.6 9.0 0.022 14.6 9.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF5404 PF17397.2 PIK48694.1 - 0.19 11.8 6.6 0.47 10.6 1.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5404) zf-RING_6 PF14835.6 PIK48694.1 - 2.7 7.9 6.6 0.52 10.2 2.2 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DnaJ_C PF01556.18 PIK48695.1 - 1.3e-41 142.2 0.4 2.6e-41 141.1 0.4 1.4 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.31 PIK48695.1 - 7.3e-25 86.9 0.7 1.2e-24 86.2 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 PIK48695.1 - 9.3e-15 54.7 23.3 1.6e-14 54.0 23.3 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 PIK48695.1 - 0.021 14.8 8.9 0.78 9.8 0.2 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PKD_channel PF08016.12 PIK48696.1 - 1.1e-101 340.7 15.8 1.9e-101 339.8 15.8 1.4 1 0 0 1 1 1 1 Polycystin cation channel REJ PF02010.15 PIK48696.1 - 3.6e-76 256.8 0.1 8.7e-76 255.5 0.1 1.7 1 0 0 1 1 1 1 REJ domain PLAT PF01477.23 PIK48696.1 - 6.6e-22 78.3 0.0 1.8e-21 76.9 0.0 1.8 1 0 0 1 1 1 1 PLAT/LH2 domain GPS PF01825.21 PIK48696.1 - 1.8e-09 37.9 8.5 6.7e-09 36.1 8.5 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD PF00801.20 PIK48696.1 - 6e-05 22.8 8.0 0.23 11.4 0.3 4.5 4 0 0 4 4 4 2 PKD domain Metaviral_G PF09595.10 PIK48696.1 - 0.011 15.9 0.7 0.03 14.4 0.7 1.8 1 0 0 1 1 1 0 Metaviral_G glycoprotein Y_Y_Y PF07495.13 PIK48696.1 - 0.014 15.3 0.4 3.6 7.6 0.0 3.2 3 0 0 3 3 3 0 Y_Y_Y domain TMEM208_SND2 PF05620.11 PIK48697.1 - 7.5e-50 169.0 4.3 8.9e-50 168.8 4.3 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 PhoLip_ATPase_C PF16212.5 PIK48697.1 - 0.00017 21.4 3.8 0.0011 18.8 0.8 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal TerC PF03741.16 PIK48697.1 - 0.042 13.5 6.6 0.032 13.9 2.3 2.0 1 1 0 2 2 2 0 Integral membrane protein TerC family Phage_holin_3_6 PF07332.11 PIK48697.1 - 0.047 13.7 1.0 0.047 13.7 1.0 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Cupin_8 PF13621.6 PIK48698.1 - 2.5e-12 47.0 0.0 2.6e-10 40.4 0.0 2.2 1 1 1 2 2 2 2 Cupin-like domain JmjC PF02373.22 PIK48698.1 - 0.033 14.6 0.3 1.7 9.1 0.0 2.8 2 1 1 3 3 3 0 JmjC domain, hydroxylase Peptidase_M41 PF01434.18 PIK48699.1 - 2.9e-65 219.7 0.0 4.7e-65 219.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 PIK48699.1 - 1.4e-39 135.5 0.0 3.5e-39 134.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK48699.1 - 4.3e-10 39.2 0.0 1.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 PIK48699.1 - 4.5e-06 26.7 0.1 3e-05 24.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 PIK48699.1 - 0.00028 21.3 0.3 0.00079 19.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 PIK48699.1 - 0.00072 19.3 0.0 0.0051 16.6 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK48699.1 - 0.00074 19.9 0.2 0.004 17.5 0.2 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK48699.1 - 0.0011 19.3 0.0 0.054 13.8 0.0 2.8 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 PIK48699.1 - 0.002 17.4 0.1 0.0039 16.4 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 PIK48699.1 - 0.0021 18.2 0.0 0.0055 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 PIK48699.1 - 0.008 16.4 0.0 0.1 12.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK48699.1 - 0.0087 15.8 0.4 0.033 13.9 0.1 2.2 2 2 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 PIK48699.1 - 0.019 14.4 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 PIK48699.1 - 0.086 13.4 0.0 0.26 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK48699.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DUF1759 PF03564.15 PIK48700.1 - 4.9e-09 36.3 0.1 3.6e-08 33.5 0.0 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1759) CALCOCO1 PF07888.11 PIK48700.1 - 0.011 14.7 1.2 0.014 14.3 1.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF5641 PF18701.1 PIK48701.1 - 4.1e-29 100.6 2.3 6.2e-29 100.0 2.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) NYD-SP28_assoc PF14775.6 PIK48701.1 - 0.027 14.5 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain Peptidase_A17 PF05380.13 PIK48702.1 - 2e-24 86.4 0.1 3.7e-24 85.5 0.1 1.5 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK48702.1 - 1.1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RESP18 PF14948.6 PIK48702.1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 RESP18 domain DUF1758 PF05585.12 PIK48703.1 - 3.2e-07 30.3 0.0 4.1e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 PIK48703.1 - 7.4e-06 26.5 0.0 1.9e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK48703.1 - 7.9e-05 23.1 0.0 0.00023 21.7 0.0 1.9 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease DUF1759 PF03564.15 PIK48704.1 - 6.6e-11 42.3 0.3 3e-10 40.2 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1759) CALCOCO1 PF07888.11 PIK48704.1 - 0.017 14.0 1.2 0.024 13.5 1.2 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like SRC-1 PF08832.10 PIK48705.1 - 2.1 9.4 9.1 0.27 12.3 2.1 2.4 2 1 0 2 2 2 0 Steroid receptor coactivator PsaA_PsaB PF00223.19 PIK48706.1 - 0.13 10.4 0.0 0.18 10.0 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein PAP_assoc PF03828.19 PIK48707.1 - 8.9e-11 41.8 0.7 1.2e-10 41.4 0.7 1.3 1 0 0 1 1 1 1 Cid1 family poly A polymerase FtsH_ext PF06480.15 PIK48708.1 - 1.7e-05 25.2 0.0 3.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 FtsH Extracellular Exo5 PF09810.9 PIK48708.1 - 0.087 12.3 0.5 0.093 12.2 0.5 1.1 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease PAP_assoc PF03828.19 PIK48710.1 - 7.1e-13 48.6 0.2 1.5e-12 47.5 0.2 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase PAP_assoc PF03828.19 PIK48711.1 - 1.4e-10 41.2 0.2 3.8e-10 39.8 0.2 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase DUF4642 PF15484.6 PIK48711.1 - 0.31 11.3 3.7 0.25 11.6 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4642) FAM219A PF15260.6 PIK48711.1 - 0.34 11.3 2.6 0.73 10.2 2.6 1.5 1 0 0 1 1 1 0 Protein family FAM219A Macoilin PF09726.9 PIK48711.1 - 9.3 4.7 11.9 13 4.2 11.9 1.2 1 0 0 1 1 1 0 Macoilin family Acyl_transf_1 PF00698.21 PIK48712.1 - 0.0066 16.0 0.0 0.008 15.7 0.0 1.0 1 0 0 1 1 1 1 Acyl transferase domain PAP_assoc PF03828.19 PIK48713.1 - 3.9e-12 46.2 1.5 7e-12 45.4 0.4 2.1 2 0 0 2 2 2 1 Cid1 family poly A polymerase Pkinase PF00069.25 PIK48715.1 - 9.2e-11 41.6 0.0 9.5e-11 41.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48715.1 - 0.0011 18.4 0.0 0.0011 18.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RabGAP-TBC PF00566.18 PIK48717.1 - 8.5e-09 35.4 4.9 2.1e-08 34.1 4.9 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain EnY2 PF10163.9 PIK48718.1 - 0.089 13.2 1.0 0.36 11.2 0.4 2.2 1 1 1 2 2 2 0 Transcription factor e(y)2 Cullin_Nedd8 PF10557.9 PIK48718.1 - 0.1 12.7 2.1 4.9 7.3 0.1 2.5 1 1 1 2 2 2 0 Cullin protein neddylation domain HEPN_SAV_6107 PF18726.1 PIK48718.1 - 0.14 12.6 0.1 1.4 9.5 0.0 2.2 2 0 0 2 2 2 0 SAV_6107-like HEPN 7tm_1 PF00001.21 PIK48719.1 - 1.1e-55 188.8 15.8 1.1e-55 188.8 15.8 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK48719.1 - 2e-08 33.9 23.0 2e-08 33.9 23.0 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK48719.1 - 1e-06 28.6 17.3 1e-06 28.6 17.3 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Flavi_capsid PF01003.19 PIK48719.1 - 0.043 13.6 1.1 0.14 11.9 1.1 1.8 1 0 0 1 1 1 0 Flavivirus capsid protein C Tmemb_9 PF05434.11 PIK48719.1 - 0.53 10.2 2.7 1.6 8.7 0.4 2.5 2 1 1 3 3 3 0 TMEM9 7tm_4 PF13853.6 PIK48719.1 - 1 9.1 19.2 0.1 12.3 12.4 2.4 2 1 0 2 2 2 0 Olfactory receptor Ank_5 PF13857.6 PIK48720.1 - 7.1e-18 64.5 0.2 2.5e-09 37.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK48720.1 - 2.1e-16 60.3 0.1 3.5e-15 56.4 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK48720.1 - 1.1e-15 57.7 0.0 7.6e-08 32.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK48720.1 - 1.8e-13 49.3 0.1 3.5e-07 30.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 PIK48720.1 - 5.8e-11 42.3 0.3 7.6e-06 26.1 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat zf-NF-X1 PF01422.17 PIK48721.1 - 0.00045 20.2 37.1 0.0014 18.6 14.0 17.0 18 1 0 18 18 18 8 NF-X1 type zinc finger Vma12 PF11712.8 PIK48721.1 - 0.026 14.6 0.7 0.05 13.7 0.7 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CRA PF06589.11 PIK48721.1 - 0.033 14.3 8.6 0.56 10.3 4.1 2.4 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) DUF883 PF05957.13 PIK48721.1 - 0.13 12.9 1.7 0.28 11.8 1.7 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) EOS1 PF12326.8 PIK48721.1 - 0.23 11.4 0.3 0.45 10.4 0.3 1.4 1 0 0 1 1 1 0 N-glycosylation protein OST3_OST6 PF04756.13 PIK48722.1 - 4.4e-107 357.8 1.4 6.5e-107 357.2 1.4 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 PIK48722.1 - 2e-05 24.5 0.1 3.5e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Sigma_reg_N PF13800.6 PIK48722.1 - 0.07 13.4 1.2 44 4.4 0.0 3.4 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Gram_pos_anchor PF00746.21 PIK48722.1 - 0.19 11.7 0.2 0.19 11.7 0.2 2.5 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Wzy_C PF04932.15 PIK48722.1 - 0.29 10.8 4.2 1.3 8.6 0.0 2.9 3 0 0 3 3 3 0 O-Antigen ligase RVT_1 PF00078.27 PIK48723.1 - 2e-36 125.6 0.0 3.7e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CreA PF05981.12 PIK48723.1 - 0.051 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 CreA protein Exo_endo_phos_2 PF14529.6 PIK48723.1 - 0.079 12.8 0.3 0.27 11.1 0.3 2.0 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Sedlin_N PF04628.13 PIK48724.1 - 2.9e-28 98.6 0.3 1.2e-13 51.3 0.1 2.0 1 1 1 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.12 PIK48724.1 - 7.7e-07 29.1 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family PSI_PsaE PF02427.17 PIK48725.1 - 0.089 12.5 0.1 0.43 10.3 0.0 2.1 1 1 1 2 2 2 0 Photosystem I reaction centre subunit IV / PsaE TPR_10 PF13374.6 PIK48725.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-Tim10_DDP PF02953.15 PIK48726.1 - 8.8e-23 79.7 1.2 1e-22 79.5 1.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TPK_catalytic PF04263.16 PIK48727.1 - 5.7e-36 123.2 0.0 7.5e-36 122.8 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 PIK48727.1 - 2.3e-05 24.0 0.1 4.2e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Peptidase_C15 PF01470.17 PIK48727.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyroglutamyl peptidase LacAB_rpiB PF02502.18 PIK48727.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribose/Galactose Isomerase DUF2228 PF10228.9 PIK48729.1 - 7.4e-94 314.2 0.0 1e-93 313.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) zf-CCHH PF10283.9 PIK48729.1 - 1.8e-11 43.8 4.8 1.8e-11 43.8 4.8 2.0 2 0 0 2 2 2 1 PBZ domain zf-CCCH_2 PF14608.6 PIK48729.1 - 1.5 9.4 4.6 0.63 10.6 1.9 1.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF4910 PF16254.5 PIK48730.1 - 0.12 11.2 0.1 0.93 8.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4910) Gln-synt_C PF00120.24 PIK48731.1 - 1.3e-76 257.8 0.0 1.8e-76 257.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 PIK48731.1 - 3.4e-07 29.9 0.2 1.5e-06 27.8 0.2 2.0 1 1 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.5 PIK48731.1 - 1.4e-05 24.9 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain CDP-OH_P_transf PF01066.21 PIK48732.1 - 1.7e-18 67.1 0.1 1.7e-18 67.1 0.1 3.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase EamA PF00892.20 PIK48733.1 - 8.6e-19 68.1 37.6 3.9e-12 46.5 9.8 2.0 2 0 0 2 2 2 2 EamA-like transporter family AA_permease_C PF13906.6 PIK48733.1 - 2.8 8.1 10.7 4.2 7.5 2.8 2.9 2 0 0 2 2 2 0 C-terminus of AA_permease NDT80_PhoG PF05224.12 PIK48734.1 - 2.2e-27 96.5 1.4 3.9e-26 92.4 1.4 2.4 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 PIK48734.1 - 2.1e-16 58.8 0.6 4.6e-16 57.7 0.6 1.6 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 MRF_C2 PF13888.6 PIK48734.1 - 2e-15 56.9 0.2 5.3e-15 55.5 0.2 1.6 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 Peptidase_S74 PF13884.6 PIK48734.1 - 1.7e-10 41.1 1.4 1.8e-10 41.0 0.1 1.8 2 0 0 2 2 2 1 Chaperone of endosialidase Metallophos_2 PF12850.7 PIK48734.1 - 0.039 14.2 0.1 0.13 12.4 0.0 1.8 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain G_path_suppress PF15991.5 PIK48734.1 - 0.093 12.9 0.5 0.31 11.1 0.1 2.0 2 0 0 2 2 2 0 G-protein pathway suppressor zf-C3HC4 PF00097.25 PIK48735.1 - 7.8e-10 38.5 6.8 7.8e-10 38.5 6.8 2.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK48735.1 - 4.9e-09 36.2 7.3 4.9e-09 36.2 7.3 2.9 2 2 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 PIK48735.1 - 7.8e-09 35.4 13.5 4.7e-08 32.9 4.9 3.2 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK48735.1 - 1.3e-06 28.1 7.2 1.3e-06 28.1 7.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK48735.1 - 2e-06 27.6 9.5 2e-06 27.6 9.5 3.0 2 2 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK48735.1 - 1.5e-05 25.2 9.4 1.5e-05 25.2 9.4 2.4 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK48735.1 - 0.00029 20.7 8.6 0.00029 20.7 8.6 2.7 2 1 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK48735.1 - 0.067 13.3 3.1 0.22 11.6 3.1 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 PIK48735.1 - 0.18 11.6 4.4 0.35 10.7 4.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 PIK48735.1 - 0.43 10.4 8.6 5.4 6.9 5.2 2.8 2 1 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 PIK48735.1 - 1.2 9.1 21.1 0.22 11.4 9.7 3.7 3 2 1 4 4 4 0 Prokaryotic RING finger family 4 Trm112p PF03966.16 PIK48735.1 - 3.1 8.4 8.8 0.4 11.3 4.3 1.8 2 0 0 2 2 2 0 Trm112p-like protein Aminotran_4 PF01063.19 PIK48736.1 - 2.2e-14 53.9 0.0 1.5e-08 34.8 0.0 2.2 2 0 0 2 2 2 2 Amino-transferase class IV PH_4 PF15404.6 PIK48736.1 - 0.15 11.9 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Aminotran_4 PF01063.19 PIK48737.1 - 0.0055 16.6 0.0 0.0077 16.1 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV zf-C4 PF00105.18 PIK48739.1 - 9.8e-16 58.0 8.6 1.1e-15 57.9 8.6 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK48740.1 - 6.8e-08 32.3 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Sarcoglycan_1 PF04790.13 PIK48742.1 - 2e-37 128.9 0.0 2.4e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2807 PF10988.8 PIK48742.1 - 0.061 13.1 1.1 0.13 12.0 1.1 1.5 1 1 0 1 1 1 0 Putative auto-transporter adhesin, head GIN domain rve PF00665.26 PIK48743.1 - 7e-22 77.9 0.0 1.2e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48743.1 - 1e-19 70.3 0.8 1.8e-19 69.6 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK48743.1 - 0.006 16.3 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK48743.1 - 0.012 15.8 0.1 0.023 14.9 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger DUF5332 PF17266.2 PIK48743.1 - 0.018 14.7 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5332) Gln-synt_C PF00120.24 PIK48744.1 - 2.7e-64 217.4 0.0 3.2e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_C PF00120.24 PIK48745.1 - 9.3e-80 268.2 0.0 1.7e-73 247.6 0.0 2.1 1 1 1 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 PIK48745.1 - 0.00032 20.5 0.0 0.001 18.9 0.0 1.9 2 0 0 2 2 2 1 Glutamine synthetase N-terminal domain Gln-synt_N PF03951.19 PIK48745.1 - 0.0046 16.7 0.0 6 6.7 0.0 3.3 3 0 0 3 3 3 2 Glutamine synthetase, beta-Grasp domain RVT_1 PF00078.27 PIK48746.1 - 7.4e-06 25.6 0.0 1.8e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gln-synt_C PF00120.24 PIK48748.1 - 1.9e-78 263.9 0.0 2.2e-78 263.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Peptidase_M14 PF00246.24 PIK48749.1 - 4.7e-74 249.8 0.0 6.2e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK48749.1 - 1.8e-20 73.1 0.0 4.9e-20 71.7 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Kinesin PF00225.23 PIK48750.1 - 8.1e-121 403.0 0.0 1e-120 402.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK48750.1 - 1.7e-27 96.2 0.0 5.6e-27 94.5 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding PIF1 PF05970.14 PIK48750.1 - 0.0055 15.9 0.1 0.011 15.0 0.1 1.4 1 0 0 1 1 1 1 PIF1-like helicase Kinesin_assoc PF16183.5 PIK48750.1 - 0.016 15.4 0.3 0.039 14.1 0.0 1.8 2 0 0 2 2 2 0 Kinesin-associated Bac_DnaA PF00308.18 PIK48750.1 - 0.032 14.1 0.1 0.095 12.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_30 PF13604.6 PIK48750.1 - 0.041 13.6 0.0 0.075 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK48750.1 - 0.043 14.1 0.0 0.17 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain 7tm_1 PF00001.21 PIK48752.1 - 2.8e-23 82.6 2.9 3.6e-23 82.2 2.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Spo7 PF03907.13 PIK48752.1 - 0.0069 15.9 4.6 0.25 10.8 0.2 2.2 2 0 0 2 2 2 2 Spo7-like protein Gaa1 PF04114.14 PIK48752.1 - 0.021 13.9 1.3 0.031 13.3 1.3 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component DUF1467 PF07330.12 PIK48752.1 - 0.026 14.4 1.7 5 7.1 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1467) DUF5345 PF17280.2 PIK48752.1 - 0.58 10.2 3.6 0.41 10.6 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF1282 PF06930.12 PIK48752.1 - 1.5 8.6 7.4 1.9 8.2 0.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1282) MpPF26 PF07666.11 PIK48752.1 - 3.6 7.7 10.5 0.15 12.2 0.9 2.6 3 0 0 3 3 3 0 M penetrans paralogue family 26 7tm_1 PF00001.21 PIK48753.1 - 5.1e-20 71.9 11.8 5.9e-20 71.7 11.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK48753.1 - 2.5e-05 23.7 4.9 3.2e-05 23.4 4.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw PGG PF13962.6 PIK48753.1 - 0.0053 16.6 0.2 0.0053 16.6 0.2 2.9 3 1 0 4 4 4 1 Domain of unknown function DUF898 PF05987.13 PIK48753.1 - 0.04 13.0 2.5 0.053 12.6 2.5 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) MARVEL PF01284.23 PIK48753.1 - 0.42 10.6 7.8 2.4 8.2 0.6 2.4 1 1 0 2 2 2 0 Membrane-associating domain EamA PF00892.20 PIK48754.1 - 8.7e-14 51.9 31.6 1.9e-10 41.1 10.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family NTF2 PF02136.20 PIK48755.1 - 1.8e-09 38.2 0.0 2.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 PIK48755.1 - 0.049 13.6 0.0 0.059 13.3 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 RVT_1 PF00078.27 PIK48756.1 - 0.00055 19.5 0.0 0.019 14.5 0.0 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribonuc_red_lgC PF02867.15 PIK48757.1 - 5e-148 493.9 0.0 6.5e-148 493.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ly-6_related PF06579.12 PIK48757.1 - 0.12 12.6 0.3 0.27 11.5 0.3 1.5 1 0 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein ig PF00047.25 PIK48759.1 - 2e-06 27.9 3.4 0.042 14.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK48759.1 - 6.3e-06 26.7 2.0 0.061 13.9 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK48759.1 - 0.0003 20.9 2.2 0.00094 19.3 0.2 2.4 2 1 1 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK48759.1 - 0.012 15.7 1.1 0.024 14.7 1.1 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK48759.1 - 0.048 14.1 3.4 0.07 13.5 2.0 1.9 2 1 0 2 2 2 0 Immunoglobulin C1-set domain ig PF00047.25 PIK48760.1 - 1.4e-06 28.4 5.4 0.0086 16.2 0.6 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK48760.1 - 0.00042 20.3 2.7 0.0035 17.4 0.3 2.8 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK48760.1 - 0.026 14.7 3.0 0.12 12.5 0.4 2.9 3 2 0 3 3 3 0 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 PIK48760.1 - 0.14 12.1 6.5 1.7 8.7 0.4 3.1 2 2 1 3 3 3 0 Ig-like C2-type domain NACHT PF05729.12 PIK48761.1 - 2.1e-05 24.5 0.0 0.00012 22.0 0.0 2.2 1 1 0 1 1 1 1 NACHT domain C1-set PF07654.15 PIK48761.1 - 0.0037 17.6 0.5 0.019 15.3 0.5 2.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK48761.1 - 0.081 13.0 0.3 0.081 13.0 0.3 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Hyr1 PF15789.5 PIK48761.1 - 0.087 12.4 0.3 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Hyphally regulated cell wall GPI-anchored protein 1 NLRC4_HD2 PF17776.1 PIK48761.1 - 5.8 7.5 8.3 7.5 7.1 1.4 3.7 2 1 0 2 2 2 0 NLRC4 helical domain HD2 ATP-synt_ab PF00006.25 PIK48762.1 - 1.3e-108 361.6 0.0 1.9e-108 361.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 PIK48762.1 - 4.8e-43 145.9 0.0 1e-42 144.8 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 PIK48762.1 - 1.4e-11 44.7 1.7 3.7e-11 43.4 1.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Acetyltransf_1 PF00583.25 PIK48763.1 - 0.064 13.5 0.0 0.075 13.3 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 PIK48764.1 - 0.0084 16.3 0.4 0.011 15.9 0.3 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK48764.1 - 0.02 14.9 0.0 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.7 PIK48764.1 - 0.031 14.7 0.1 0.054 13.9 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_4C PF11975.8 PIK48764.1 - 0.061 13.4 0.5 0.061 13.4 0.5 1.0 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain Glycos_transf_4 PF00953.21 PIK48765.1 - 3.7e-36 124.5 12.0 3.7e-36 124.5 12.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 4 zf-C4 PF00105.18 PIK48766.1 - 3.3e-29 101.1 18.4 6.4e-29 100.2 18.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK48766.1 - 9.5e-29 100.5 0.4 1.7e-28 99.6 0.4 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ribosomal_60s PF00428.19 PIK48767.1 - 1.9e-26 92.4 3.7 2.3e-26 92.2 3.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 PIK48767.1 - 0.25 12.0 1.7 0.4 11.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Cytomega_UL84 PF06284.11 PIK48767.1 - 0.31 9.4 0.2 0.38 9.2 0.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein OAF PF14941.6 PIK48768.1 - 2.5e-56 190.8 0.6 3.4e-56 190.4 0.6 1.1 1 0 0 1 1 1 1 Transcriptional regulator, Out at first CENP-B_dimeris PF09026.10 PIK48768.1 - 0.032 14.6 10.5 0.057 13.8 10.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BRICHOS PF04089.14 PIK48768.1 - 0.035 14.3 0.1 0.076 13.3 0.1 1.5 1 0 0 1 1 1 0 BRICHOS domain RRN3 PF05327.11 PIK48768.1 - 0.081 11.5 8.8 0.099 11.2 8.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 PIK48768.1 - 8.9 5.3 13.4 22 4.0 13.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-C2H2 PF00096.26 PIK48769.1 - 0.00032 21.0 0.9 0.00073 19.9 0.9 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK48769.1 - 0.0018 18.5 0.6 0.0018 18.5 0.6 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK48769.1 - 0.0061 17.3 1.1 0.02 15.7 1.1 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger GREB1 PF15782.5 PIK48769.1 - 0.18 8.9 28.1 0.25 8.4 28.1 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CENP-M PF11111.8 PIK48769.1 - 1.4 8.0 6.1 3 7.0 6.1 1.5 1 0 0 1 1 1 0 Centromere protein M (CENP-M) DUF4776 PF16003.5 PIK48769.1 - 5 6.0 32.4 8.1 5.3 32.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) zf-C2H2 PF00096.26 PIK48770.1 - 4e-33 112.0 70.8 2.5e-05 24.5 0.5 10.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48770.1 - 3.2e-27 92.9 69.5 0.00043 20.9 0.5 10.4 10 0 0 10 10 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK48770.1 - 2.8e-17 62.3 70.7 0.00043 20.6 1.1 11.1 11 1 0 11 11 10 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK48770.1 - 2.9e-14 52.9 46.3 0.03 14.6 0.3 10.4 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK48770.1 - 2.5e-09 37.3 55.8 0.0037 17.5 8.2 9.1 7 1 2 9 9 8 4 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 PIK48770.1 - 3e-05 24.2 40.7 0.11 12.9 0.7 8.7 10 0 0 10 10 10 5 Zinc-finger of C2H2 type Actin_micro PF17003.5 PIK48770.1 - 3.8e-05 23.0 27.3 0.0083 15.3 0.0 7.3 3 3 3 7 7 7 2 Putative actin-like family zf-BED PF02892.15 PIK48770.1 - 0.00013 21.9 47.1 0.59 10.2 1.7 8.4 8 0 0 8 8 8 3 BED zinc finger zf-C2H2_2 PF12756.7 PIK48770.1 - 0.00062 20.1 47.7 0.85 10.0 1.6 9.3 4 3 4 9 9 9 4 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 PIK48770.1 - 0.0008 19.0 24.1 0.037 13.7 0.1 6.9 5 2 2 7 7 7 1 Zinc-fingers and homeoboxes C2H2 finger domain DUF629 PF04780.12 PIK48770.1 - 0.003 16.2 36.0 0.37 9.3 0.3 7.2 5 2 2 7 7 7 4 Protein of unknown function (DUF629) zinc_ribbon_15 PF17032.5 PIK48770.1 - 0.032 15.0 26.0 16 6.3 0.3 6.5 3 1 3 6 6 6 0 zinc-ribbon family zf-C2H2_6 PF13912.6 PIK48770.1 - 0.05 13.6 0.0 0.05 13.6 0.0 8.3 9 0 0 9 9 9 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 PIK48770.1 - 0.25 11.2 17.9 7.3 6.5 1.1 6.2 5 2 2 7 7 7 0 C2H2 type zinc-finger (1 copy) PyrI_C PF02748.15 PIK48770.1 - 0.33 10.9 27.0 3.1 7.8 0.1 7.4 8 0 0 8 8 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_UBZ PF18439.1 PIK48770.1 - 0.5 10.0 29.7 1.5 8.5 0.1 7.6 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 PIK48770.1 - 0.52 10.3 31.3 7.2 6.6 0.1 7.6 8 0 0 8 8 8 0 zinc-finger of a C2HC-type Zf_RING PF16744.5 PIK48770.1 - 9.8 6.4 27.9 0.057 13.5 0.9 5.9 6 1 1 7 7 6 0 KIAA1045 RING finger UPF0242 PF06785.11 PIK48771.1 - 0.007 16.5 1.7 0.012 15.8 1.7 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Anthrax_toxA PF03497.16 PIK48771.1 - 0.021 15.0 0.4 0.031 14.4 0.4 1.3 1 0 0 1 1 1 0 Anthrax toxin LF subunit DUF2570 PF10828.8 PIK48771.1 - 0.085 12.7 0.4 0.16 11.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) KdpA PF03814.15 PIK48771.1 - 0.13 10.5 0.8 0.17 10.0 0.8 1.1 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit Geminin PF07412.12 PIK48771.1 - 0.13 12.0 2.9 0.27 11.0 2.9 1.4 1 0 0 1 1 1 0 Geminin Gal-3-0_sulfotr PF06990.11 PIK48772.1 - 7.1e-53 179.9 1.7 1.1e-51 176.0 1.7 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Bacillus_HBL PF05791.11 PIK48772.1 - 0.0039 17.0 0.2 0.018 14.9 0.2 1.9 1 1 1 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) Gal-3-0_sulfotr PF06990.11 PIK48773.1 - 8.2e-82 275.2 5.4 5.5e-81 272.5 5.3 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK48773.1 - 9.1e-08 32.3 0.9 9.5e-07 29.0 0.9 2.3 1 1 0 1 1 1 1 Sulfotransferase family Bacillus_HBL PF05791.11 PIK48773.1 - 0.02 14.7 0.2 0.075 12.9 0.1 1.7 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HLH PF00010.26 PIK48774.1 - 1.9e-18 66.1 0.1 1.9e-18 66.1 0.1 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Ribosomal_S25 PF03297.15 PIK48775.1 - 2.3e-36 124.0 3.2 2.9e-36 123.7 3.2 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Fe_dep_repress PF01325.19 PIK48775.1 - 0.093 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain RVT_1 PF00078.27 PIK48776.1 - 3.8e-24 85.5 0.1 8e-24 84.4 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48776.1 - 3e-10 40.0 0.0 7.9e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF3896 PF13035.6 PIK48776.1 - 0.1 12.8 1.1 0.23 11.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) GPS PF01825.21 PIK48777.1 - 2.2e-19 69.7 3.1 4.7e-19 68.7 3.1 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK48777.1 - 6.6e-14 51.8 14.7 8.9e-14 51.4 14.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Arv1 PF04161.13 PIK48777.1 - 1 9.5 11.1 2 8.5 11.0 1.5 1 1 0 1 1 1 0 Arv1-like family GPS PF01825.21 PIK48778.1 - 0.008 16.7 0.6 0.015 15.9 0.6 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TOM6p PF15184.6 PIK48778.1 - 0.084 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog gag-asp_proteas PF13975.6 PIK48779.1 - 0.0011 19.5 0.0 0.0028 18.2 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK48779.1 - 0.0015 19.1 0.0 0.0033 18.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 PIK48779.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) zf-CCHC_5 PF14787.6 PIK48779.1 - 0.95 9.2 6.4 0.067 12.9 0.9 2.0 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RbpA PF13397.6 PIK48780.1 - 0.74 10.5 4.6 0.45 11.2 1.8 2.0 2 0 0 2 2 2 0 RNA polymerase-binding protein PDT PF00800.18 PIK48781.1 - 0.071 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydratase AAA_34 PF13872.6 PIK48782.1 - 2.4e-124 414.1 0.0 3.9e-124 413.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 ResIII PF04851.15 PIK48782.1 - 0.0015 18.6 0.0 0.0037 17.3 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Zot PF05707.12 PIK48782.1 - 0.046 13.4 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) Helicase_C_4 PF13871.6 PIK48783.1 - 2.8e-105 351.9 0.1 8e-90 301.2 0.2 2.6 1 1 1 2 2 2 2 C-terminal domain on Strawberry notch homologue Helicase_C PF00271.31 PIK48783.1 - 0.11 12.8 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 Helicase conserved C-terminal domain CDV3 PF15359.6 PIK48783.1 - 0.12 12.8 9.0 0.099 13.1 6.8 1.9 1 1 0 1 1 1 0 Carnitine deficiency-associated protein 3 BUD22 PF09073.10 PIK48783.1 - 0.56 9.5 29.6 0.9 8.8 29.6 1.3 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 PIK48783.1 - 1.6 7.2 38.6 2.5 6.6 38.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2655 PF10848.8 PIK48784.1 - 0.18 12.1 16.8 36 4.8 1.1 5.3 2 1 5 7 7 7 0 Protein of unknown function (DUF2655) Fer4_3 PF12798.7 PIK48784.1 - 1.6 9.8 11.3 75 4.6 0.6 4.8 3 0 0 3 3 3 0 4Fe-4S binding domain DNA_RNApol_7kD PF03604.13 PIK48784.1 - 5.5 6.8 8.5 54 3.6 0.1 4.5 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Tocopherol_cycl PF14249.6 PIK48785.1 - 1.6e-05 24.3 1.9 1.8e-05 24.0 1.9 1.0 1 0 0 1 1 1 1 Tocopherol cyclase Myosin_head PF00063.21 PIK48786.1 - 1.2e-10 40.3 0.0 1.6e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Alginate_lyase PF05426.12 PIK48786.1 - 0.061 12.9 0.4 0.094 12.3 0.1 1.4 2 0 0 2 2 2 0 Alginate lyase Myosin_head PF00063.21 PIK48787.1 - 1.7e-46 158.8 0.0 2e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_head PF00063.21 PIK48788.1 - 1.5e-24 86.3 8.7 3.8e-23 81.6 0.0 3.6 2 1 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 PIK48788.1 - 2.1e-11 42.4 128.6 2.1e-11 42.4 128.6 3.3 1 1 0 2 2 2 1 Myosin tail IQ PF00612.27 PIK48788.1 - 1.7e-06 27.3 2.9 2.5e-05 23.7 0.1 2.8 2 0 0 2 2 2 1 IQ calmodulin-binding motif Filament PF00038.21 PIK48788.1 - 0.0037 16.9 18.2 0.0037 16.9 18.2 5.5 1 1 2 3 3 3 1 Intermediate filament protein TIG_2 PF18020.1 PIK48789.1 - 1.9e-14 54.0 0.0 4.8e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 TIG domain found in plexin TIG PF01833.24 PIK48789.1 - 3e-14 52.8 10.0 6.1e-09 35.8 0.6 4.4 4 0 0 4 4 4 2 IPT/TIG domain Sema PF01403.19 PIK48789.1 - 1.5e-10 40.5 0.0 2.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 PIK48789.1 - 0.0029 18.1 5.9 0.0029 18.1 5.9 3.0 3 0 0 3 3 3 1 Plexin repeat Plexin_cytopl PF08337.12 PIK48790.1 - 6e-129 431.2 1.2 2.4e-125 419.4 0.3 2.1 1 1 1 2 2 2 2 Plexin cytoplasmic RasGAP domain Sema PF01403.19 PIK48790.1 - 2.6e-47 161.6 0.0 5.7e-47 160.5 0.0 1.7 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 PIK48790.1 - 1e-31 108.8 17.5 3.9e-08 33.3 1.2 6.3 6 0 0 6 6 6 5 IPT/TIG domain PSI PF01437.25 PIK48790.1 - 1.3e-15 57.6 54.4 5e-07 30.2 15.2 3.9 3 0 0 3 3 3 3 Plexin repeat TIG_2 PF18020.1 PIK48790.1 - 9e-13 48.7 0.0 4.2e-08 33.7 0.0 3.7 2 1 0 2 2 2 2 TIG domain found in plexin TIG_plexin PF17960.1 PIK48790.1 - 7.5e-08 32.3 1.4 2.2e-07 30.8 0.0 2.7 3 0 0 3 3 3 1 TIG domain DUF3481 PF11980.8 PIK48790.1 - 0.018 14.8 0.6 0.044 13.5 0.6 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Glycophorin_A PF01102.18 PIK48790.1 - 0.066 13.5 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Glycophorin A EphA2_TM PF14575.6 PIK48790.1 - 0.097 13.6 0.2 0.28 12.1 0.2 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 PIK48790.1 - 0.22 11.3 17.6 0.6 9.9 17.6 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Plexin_cytopl PF08337.12 PIK48791.1 - 9.8e-28 97.1 2.1 1.2e-27 96.9 2.1 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Kinesin PF00225.23 PIK48793.1 - 1e-98 330.4 0.5 1e-98 330.4 0.5 1.5 2 0 0 2 2 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK48793.1 - 2.3e-50 170.4 0.2 2.3e-50 170.4 0.2 2.0 2 0 0 2 2 1 1 Microtubule binding ERM PF00769.19 PIK48793.1 - 2.5e-07 30.8 7.0 5e-07 29.8 7.0 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK48793.1 - 9.1e-05 23.0 2.6 9.1e-05 23.0 2.6 2.5 2 0 0 2 2 2 1 Apg6 coiled-coil region HAUS-augmin3 PF14932.6 PIK48793.1 - 0.00058 19.5 5.0 0.00065 19.4 3.1 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 PIK48793.1 - 0.0018 18.4 6.3 0.0018 18.4 6.3 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Rootletin PF15035.6 PIK48793.1 - 0.0021 18.1 3.2 0.0049 16.9 3.2 1.6 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion CCDC144C PF14915.6 PIK48793.1 - 0.005 16.0 9.7 0.011 14.9 9.7 1.5 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region CENP-F_leu_zip PF10473.9 PIK48793.1 - 0.006 16.6 9.5 0.006 16.6 9.5 2.1 2 0 0 2 2 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 PIK48793.1 - 0.012 16.1 10.8 0.031 14.7 10.8 1.7 1 0 0 1 1 1 0 Fez1 NPV_P10 PF05531.12 PIK48793.1 - 0.05 14.1 1.1 0.26 11.8 1.1 2.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 PIK48793.1 - 0.068 12.0 8.9 0.16 10.8 8.9 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 PIK48793.1 - 0.076 13.0 26.6 0.049 13.6 17.0 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-C4H2 PF10146.9 PIK48793.1 - 0.089 13.1 11.2 0.25 11.6 11.2 1.7 1 0 0 1 1 1 0 Zinc finger-containing protein EMP24_GP25L PF01105.24 PIK48793.1 - 0.095 12.6 1.9 0.31 11.0 1.9 1.9 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF4686 PF15742.5 PIK48793.1 - 0.097 11.8 11.8 0.66 9.0 7.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) DUF1664 PF07889.12 PIK48793.1 - 0.13 12.3 3.5 0.42 10.6 3.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HALZ PF02183.18 PIK48793.1 - 0.14 12.4 10.0 0.023 14.9 4.6 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 PIK48793.1 - 0.16 12.4 8.4 0.68 10.4 8.4 2.1 1 0 0 1 1 1 0 Cell division protein ZapB Allexi_40kDa PF05549.11 PIK48793.1 - 0.27 10.7 4.3 0.68 9.4 4.3 1.6 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF3450 PF11932.8 PIK48793.1 - 0.28 10.4 9.2 0.095 12.0 5.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 PIK48793.1 - 0.5 8.2 4.9 0.83 7.5 4.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5082 PF16888.5 PIK48793.1 - 0.74 10.1 9.2 1.1 9.6 6.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4337 PF14235.6 PIK48793.1 - 0.92 9.6 5.0 2 8.5 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) CtIP_N PF10482.9 PIK48793.1 - 1.1 9.3 10.9 0.074 13.1 5.3 1.9 2 0 0 2 2 1 0 Tumour-suppressor protein CtIP N-terminal domain GAS PF13851.6 PIK48793.1 - 1.2 8.5 21.7 0.034 13.5 14.4 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ACCA PF03255.14 PIK48793.1 - 1.3 8.8 5.6 3.7 7.4 5.6 1.8 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit PI3K_P85_iSH2 PF16454.5 PIK48793.1 - 1.3 8.6 13.9 0.041 13.5 6.9 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain YabA PF06156.13 PIK48793.1 - 1.5 9.5 21.4 0.026 15.1 8.8 3.6 4 0 0 4 4 2 0 Initiation control protein YabA Cnn_1N PF07989.11 PIK48793.1 - 1.5 9.1 13.8 0.11 12.7 6.4 2.6 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 FlxA PF14282.6 PIK48793.1 - 1.9 8.6 8.2 1.1 9.3 5.0 2.3 2 0 0 2 2 1 0 FlxA-like protein DUF2884 PF11101.8 PIK48793.1 - 1.9 7.9 9.7 0.12 11.8 4.5 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2884) TMPIT PF07851.13 PIK48793.1 - 2.7 7.1 9.1 5.2 6.2 9.1 1.4 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 PIK48793.1 - 4.3 7.2 13.3 0.2 11.5 4.5 3.1 2 1 1 3 3 3 0 Septum formation initiator AAA_13 PF13166.6 PIK48793.1 - 4.5 5.8 10.6 9.5 4.7 10.6 1.5 1 0 0 1 1 1 0 AAA domain PIEZO PF15917.5 PIK48793.1 - 5.5 6.4 7.6 10 5.5 7.6 1.4 1 0 0 1 1 1 0 Piezo DUF724 PF05266.14 PIK48793.1 - 7.4 6.3 15.3 0.97 9.2 9.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) FapA PF03961.13 PIK48793.1 - 8.2 4.9 10.9 2.5 6.6 7.7 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A CLZ PF16526.5 PIK48793.1 - 8.8 6.8 9.5 5.7 7.4 5.0 2.6 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Sulfotransfer_1 PF00685.27 PIK48794.1 - 3.6e-15 56.2 0.0 5.3e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK48794.1 - 6.4e-08 33.3 0.0 0.00071 20.0 0.1 2.8 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK48794.1 - 0.001 19.1 0.1 0.0015 18.5 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family CARD_2 PF16739.5 PIK48795.1 - 7.8e-20 70.7 0.5 2.1e-14 53.3 0.0 2.3 2 1 0 2 2 2 2 Caspase recruitment domain CARD PF00619.21 PIK48795.1 - 0.00022 21.2 1.7 0.0064 16.5 0.0 2.9 2 1 0 2 2 2 1 Caspase recruitment domain RIG-I_C-RD PF11648.8 PIK48796.1 - 1.6e-26 92.8 2.2 1.6e-26 92.8 2.2 2.1 2 0 0 2 2 1 1 C-terminal domain of RIG-I ResIII PF04851.15 PIK48796.1 - 1.4e-20 74.0 0.9 3.9e-20 72.5 0.1 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RIG-I_C PF18119.1 PIK48796.1 - 5.5e-20 71.8 1.5 5.5e-20 71.8 1.5 2.5 3 0 0 3 3 3 1 RIG-I receptor C-terminal domain DEAD PF00270.29 PIK48796.1 - 2.4e-19 69.8 1.0 4.7e-19 68.8 0.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK48796.1 - 2.1e-14 53.8 0.1 1.6e-13 50.9 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 PIK48796.1 - 1.9e-06 27.7 0.2 4.7e-06 26.4 0.2 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_19 PF13245.6 PIK48796.1 - 2.2e-05 24.8 1.7 0.0022 18.3 0.6 3.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK48796.1 - 0.00049 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF3638 PF12340.8 PIK48796.1 - 0.0018 17.6 0.0 0.0041 16.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) AAA_22 PF13401.6 PIK48796.1 - 0.0044 17.3 0.1 0.029 14.7 0.1 2.4 1 1 0 1 1 1 1 AAA domain Yippee-Mis18 PF03226.14 PIK48796.1 - 0.0059 16.8 2.2 0.0059 16.8 2.2 1.9 2 0 0 2 2 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PhoH PF02562.16 PIK48796.1 - 0.042 13.3 0.1 0.13 11.7 0.1 1.8 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.17 PIK48796.1 - 0.088 12.5 0.0 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 PIK48796.1 - 0.11 12.0 0.5 0.54 9.8 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 PIK48796.1 - 0.15 11.8 0.1 0.15 11.8 0.1 3.4 2 2 1 3 3 2 0 AAA domain UvrD-helicase PF00580.21 PIK48796.1 - 0.5 9.8 0.0 0.5 9.8 0.0 2.7 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain Latarcin PF10279.9 PIK48796.1 - 7.2 7.1 6.4 35 4.9 6.4 2.4 1 1 0 1 1 1 0 Latarcin precursor MYT1 PF08474.11 PIK48797.1 - 0.05 13.5 5.6 1.8 8.5 1.0 2.1 1 1 1 2 2 2 0 Myelin transcription factor 1 PAX PF00292.18 PIK48798.1 - 1.6e-26 92.7 3.0 3.5e-19 69.0 0.1 2.1 1 1 1 2 2 2 2 'Paired box' domain WH1 PF00568.23 PIK48799.1 - 3.9e-28 97.6 0.5 4.8e-28 97.3 0.5 1.1 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 PIK48800.1 - 0.0025 17.6 0.0 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 WH2 motif Peptidase_C6 PF00851.18 PIK48800.1 - 0.12 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Helper component proteinase DUF2089 PF09862.9 PIK48800.1 - 0.2 11.7 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) TIMP PF00965.17 PIK48801.1 - 8.1e-09 35.5 0.0 2e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase TruD PF01142.18 PIK48802.1 - 2.2e-68 231.0 0.2 7.6e-62 209.5 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) USP8_interact PF08941.10 PIK48802.1 - 0.03 14.1 0.2 0.18 11.6 0.1 2.2 2 0 0 2 2 2 0 USP8 interacting ArfGap PF01412.18 PIK48802.1 - 0.034 14.2 0.1 0.097 12.8 0.1 1.7 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf KOW PF00467.29 PIK48802.1 - 0.15 12.1 0.4 0.35 10.9 0.4 1.7 1 0 0 1 1 1 0 KOW motif ADH_zinc_N PF00107.26 PIK48802.1 - 0.24 11.4 0.5 2.7 8.0 0.0 2.9 4 0 0 4 4 4 0 Zinc-binding dehydrogenase RT_RNaseH PF17917.1 PIK48803.1 - 3.2e-30 104.5 0.0 1.6e-29 102.3 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK48803.1 - 1.2e-26 92.6 0.0 5.9e-26 90.4 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48803.1 - 2.1e-21 76.3 0.0 4.7e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48803.1 - 1.1e-15 57.4 0.3 3e-15 56.1 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK48803.1 - 1.5e-06 27.9 0.0 3.7e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_thumb PF06817.14 PIK48803.1 - 0.00075 19.3 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain zf-H2C2 PF09337.10 PIK48803.1 - 0.091 13.0 1.2 0.95 9.7 0.0 2.7 2 0 0 2 2 2 0 H2C2 zinc finger Claudin_2 PF13903.6 PIK48804.1 - 3.3e-05 23.7 0.1 3.3e-05 23.7 0.1 1.5 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Claudin_3 PF06653.11 PIK48804.1 - 0.00042 20.3 2.2 0.00042 20.3 2.2 2.1 2 1 0 2 2 2 1 Tight junction protein, Claudin-like SUR7 PF06687.12 PIK48804.1 - 0.048 13.3 2.6 0.11 12.0 0.1 2.1 2 0 0 2 2 2 0 SUR7/PalI family DUF3169 PF11368.8 PIK48804.1 - 0.73 9.3 6.9 4.4 6.7 5.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DHHC PF01529.20 PIK48804.1 - 9.6 6.3 7.9 18 5.5 0.1 2.6 2 1 0 2 2 2 0 DHHC palmitoyltransferase Bromodomain PF00439.25 PIK48805.1 - 1.3e-19 70.1 0.1 2.8e-19 69.0 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Tae4 PF14113.6 PIK48805.1 - 0.075 13.3 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 EPO_TPO PF00758.18 PIK48805.1 - 2.7 8.0 6.0 1.4 9.0 2.4 2.2 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin WD40 PF00400.32 PIK48806.1 - 4.5e-07 30.4 2.2 0.019 15.8 0.1 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK48806.1 - 0.046 12.7 0.1 0.091 11.7 0.1 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ArAE_1_C PF11728.8 PIK48807.1 - 0.22 11.5 9.2 0.94 9.5 0.6 3.7 4 0 0 4 4 4 0 Putative aromatic acid exporter C-terminal domain MFS_1 PF07690.16 PIK48808.1 - 3.3e-08 32.8 0.0 3.5e-08 32.7 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FTR1 PF03239.14 PIK48808.1 - 0.022 14.0 0.0 0.024 13.8 0.0 1.0 1 0 0 1 1 1 0 Iron permease FTR1 family MFS_1 PF07690.16 PIK48809.1 - 5.5e-05 22.3 0.1 6.5e-05 22.0 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FAA_hydrolase PF01557.18 PIK48810.1 - 6.3e-74 248.3 0.0 8.3e-74 247.9 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Med28 PF11594.8 PIK48811.1 - 2e-07 31.1 0.6 3.3e-07 30.4 0.6 1.3 1 0 0 1 1 1 1 Mediator complex subunit 28 Med9 PF07544.13 PIK48811.1 - 0.038 14.1 1.2 0.067 13.3 1.2 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 ING PF12998.7 PIK48811.1 - 0.05 14.2 0.7 1.1 9.9 0.1 2.2 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding XLF PF09302.11 PIK48811.1 - 0.11 12.6 0.7 0.18 12.0 0.7 1.5 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Peptidase_M17 PF00883.21 PIK48812.1 - 8.9e-123 409.5 0.0 1.6e-122 408.7 0.0 1.4 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 PIK48812.1 - 2.3e-17 63.0 0.3 2.3e-17 63.0 0.3 1.6 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain PDZ PF00595.24 PIK48813.1 - 2.7e-31 107.7 3.8 8.9e-18 64.4 0.2 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK48813.1 - 1.5e-18 66.3 0.0 2.6e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK48813.1 - 7.2e-10 39.1 0.1 0.0013 19.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain CCM2_C PF16545.5 PIK48814.1 - 0.0049 17.4 0.0 0.0089 16.5 0.0 1.3 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PDZ PF00595.24 PIK48815.1 - 3.9e-08 33.5 0.0 7.6e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain AKAP95 PF04988.12 PIK48816.1 - 0.011 16.0 0.6 0.062 13.5 0.0 2.1 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 PIK48816.1 - 0.013 15.9 0.1 0.027 14.8 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_4 PF13717.6 PIK48816.1 - 0.047 13.6 1.5 0.086 12.8 1.5 1.4 1 0 0 1 1 1 0 zinc-ribbon domain CDC45 PF02724.14 PIK48816.1 - 5.3 5.2 9.4 6.8 4.9 9.4 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3_PI4_kinase PF00454.27 PIK48817.1 - 1.2e-40 139.9 0.1 1.6e-40 139.5 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase WD40 PF00400.32 PIK48818.1 - 2.7e-09 37.5 7.0 0.35 11.8 0.0 6.8 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48818.1 - 1.4e-05 25.3 0.0 0.47 10.8 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 PIK48818.1 - 0.08 11.7 0.0 5.7 5.6 0.0 2.5 2 0 0 2 2 2 0 Nup133 N terminal like Peptidase_Mx PF15887.5 PIK48818.1 - 0.082 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase DUF4506 PF14958.6 PIK48819.1 - 5.7e-26 90.7 3.6 1.2e-25 89.6 3.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) Cactin_mid PF10312.9 PIK48819.1 - 0.13 12.0 6.4 0.034 13.9 1.3 2.2 1 1 1 2 2 2 0 Conserved mid region of cactin FUSC PF04632.12 PIK48819.1 - 4.3 5.8 7.6 6.5 5.2 7.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family LPP PF04728.13 PIK48819.1 - 5.5 7.5 9.0 6.5 7.2 0.6 3.6 2 1 1 3 3 3 0 Lipoprotein leucine-zipper MCU PF04678.13 PIK48819.1 - 7.7 6.6 8.3 0.55 10.3 0.4 2.4 2 1 0 2 2 2 0 Mitochondrial calcium uniporter DUF5401 PF17380.2 PIK48821.1 - 1 7.3 9.5 1.5 6.8 9.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) C1_2 PF03107.16 PIK48822.1 - 0.016 15.5 4.1 0.034 14.5 4.1 1.6 1 0 0 1 1 1 0 C1 domain FYVE PF01363.21 PIK48822.1 - 0.027 14.6 4.4 0.074 13.2 4.4 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-C5HC2 PF02928.16 PIK48822.1 - 0.053 13.9 4.2 0.14 12.6 4.2 1.7 1 0 0 1 1 1 0 C5HC2 zinc finger Zn_ribbon_17 PF17120.5 PIK48822.1 - 0.17 11.5 5.0 0.29 10.8 2.5 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type ARF7EP_C PF14949.6 PIK48822.1 - 6.6 7.4 9.0 13 6.5 5.1 2.9 2 0 0 2 2 2 0 ARF7 effector protein C-terminus C1_2 PF03107.16 PIK48823.1 - 0.0035 17.6 2.9 0.0079 16.5 2.9 1.7 1 0 0 1 1 1 1 C1 domain FYVE PF01363.21 PIK48823.1 - 0.016 15.4 4.4 0.041 14.0 4.4 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-C5HC2 PF02928.16 PIK48823.1 - 0.034 14.5 4.2 0.082 13.3 4.2 1.6 1 0 0 1 1 1 0 C5HC2 zinc finger Zn_ribbon_17 PF17120.5 PIK48823.1 - 0.065 12.9 2.5 0.17 11.6 2.5 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 PIK48823.1 - 0.13 12.2 3.0 0.33 10.9 3.0 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-UBP PF02148.19 PIK48823.1 - 0.22 11.9 3.1 0.58 10.5 3.1 1.8 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein NMD3 PF04981.13 PIK48823.1 - 0.47 9.9 4.8 1.1 8.7 4.8 1.5 1 0 0 1 1 1 0 NMD3 family zf-B_box PF00643.24 PIK48823.1 - 1.1 9.5 5.2 3.1 8.0 5.2 1.8 1 0 0 1 1 1 0 B-box zinc finger JmjC PF02373.22 PIK48824.1 - 2.1e-13 50.7 0.0 4.9e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 PIK48824.1 - 0.023 14.4 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 Cupin domain THEG PF14912.6 PIK48825.1 - 8.4e-54 179.9 19.2 1.3e-15 57.5 2.7 6.3 5 1 1 6 6 6 6 Testicular haploid expressed repeat UPF0258 PF06789.12 PIK48825.1 - 0.06 13.5 0.7 0.31 11.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) Rad21_Rec8 PF04824.16 PIK48826.1 - 1.2e-08 34.1 0.0 2.1e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein PWWP PF00855.17 PIK48827.1 - 1.5e-11 44.5 0.0 4.1e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 PWWP domain SPRY PF00622.28 PIK48828.1 - 9.9e-20 70.9 1.5 3.9e-15 56.0 0.1 3.3 2 2 0 2 2 2 2 SPRY domain Neuralized PF07177.12 PIK48828.1 - 0.14 12.2 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Neuralized Slu7 PF11708.8 PIK48829.1 - 1.1e-106 356.5 13.4 1.1e-106 356.5 13.4 2.2 2 0 0 2 2 2 2 Pre-mRNA splicing Prp18-interacting factor Vfa1 PF08432.10 PIK48829.1 - 3 8.1 32.7 0.042 14.2 17.0 2.9 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 PIK48829.1 - 3.6 7.7 9.9 1.6 8.9 5.9 2.2 2 0 0 2 2 2 0 DDHD domain CRT10 PF08728.10 PIK48829.1 - 5.2 5.1 17.6 0.08 11.1 2.3 2.1 2 0 0 2 2 2 0 CRT10 BROMI PF14961.6 PIK48829.1 - 7.8 3.8 9.6 11 3.3 9.6 1.1 1 0 0 1 1 1 0 Broad-minded protein zf-C4 PF00105.18 PIK48830.1 - 1.9e-27 95.5 13.2 3e-27 94.9 13.2 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK48830.1 - 1.9e-15 57.0 5.1 1.9e-15 57.0 5.1 2.1 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor DUF2536 PF10750.9 PIK48830.1 - 0.45 10.5 3.3 12 5.9 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2536) Ig_3 PF13927.6 PIK48831.1 - 3.7e-12 46.7 4.0 0.0033 18.0 0.0 3.9 3 1 1 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK48831.1 - 7.3e-11 42.2 2.4 0.0017 18.6 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK48831.1 - 1e-09 38.3 0.6 0.035 14.2 0.0 3.9 4 1 0 4 4 4 3 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK48831.1 - 6.2e-09 35.8 0.6 0.00042 20.3 0.1 2.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK48831.1 - 2.2e-07 31.0 0.7 0.0043 17.2 0.0 3.8 3 1 1 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 PIK48831.1 - 3e-05 24.1 1.5 3.3 7.9 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK48831.1 - 0.0015 18.8 3.2 0.44 10.9 0.2 2.8 2 0 0 2 2 2 2 Immunoglobulin C1-set domain RT_RNaseH_2 PF17919.1 PIK48832.1 - 2.2e-32 111.1 0.0 6.2e-32 109.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48832.1 - 1.5e-25 89.5 0.0 3.3e-25 88.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48832.1 - 1.4e-20 73.8 0.0 3.1e-20 72.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK48832.1 - 1e-09 38.4 1.3 4.3e-09 36.4 0.0 2.7 3 0 0 3 3 3 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 PIK48832.1 - 0.0026 18.3 0.2 0.0073 16.8 0.2 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.6 PIK48832.1 - 0.011 15.4 2.2 0.028 14.1 2.2 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVP PF00077.20 PIK48832.1 - 0.021 15.1 0.2 0.069 13.5 0.2 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK48832.1 - 0.03 15.0 0.1 0.085 13.5 0.1 1.9 1 0 0 1 1 1 0 Aspartyl protease Anoct_dimer PF16178.5 PIK48832.1 - 0.035 13.8 0.3 0.08 12.6 0.3 1.5 1 0 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin zf-CCHC PF00098.23 PIK48832.1 - 3.3 8.0 10.4 0.039 14.1 1.4 2.3 2 0 0 2 2 2 0 Zinc knuckle TFIIE_alpha PF02002.17 PIK48832.1 - 3.6 7.5 5.7 5.4 6.9 0.3 3.4 4 0 0 4 4 4 0 TFIIE alpha subunit Ig_3 PF13927.6 PIK48834.1 - 2.6e-11 44.0 3.2 0.011 16.3 0.3 3.5 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK48834.1 - 3.3e-11 43.1 1.1 0.00019 21.5 0.4 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK48834.1 - 4e-10 39.9 1.8 0.0028 17.9 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK48834.1 - 2.2e-07 30.8 0.3 0.33 11.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 PIK48834.1 - 4.4e-07 30.0 1.0 0.23 11.6 0.1 3.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK48834.1 - 5.5e-07 29.7 0.1 0.00061 19.9 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain C1-set PF07654.15 PIK48834.1 - 0.053 13.9 4.0 0.76 10.2 1.0 3.1 2 1 1 3 3 3 0 Immunoglobulin C1-set domain Sugar_tr PF00083.24 PIK48835.1 - 1.3e-17 63.8 16.2 1.5e-17 63.6 11.9 2.3 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK48835.1 - 1.5e-07 30.6 38.9 3.6e-06 26.1 39.4 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Cation_efflux PF01545.21 PIK48836.1 - 8.3e-29 100.7 8.4 1.1e-28 100.4 8.4 1.1 1 0 0 1 1 1 1 Cation efflux family XPA_C PF05181.12 PIK48836.1 - 0.065 13.2 0.5 0.13 12.3 0.1 1.7 2 0 0 2 2 2 0 XPA protein C-terminus Ion_trans_N PF08412.10 PIK48836.1 - 0.082 12.5 0.2 0.28 10.8 0.0 1.9 2 0 0 2 2 2 0 Ion transport protein N-terminal ZT_dimer PF16916.5 PIK48836.1 - 0.11 12.6 2.1 4.2 7.6 0.1 2.4 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter DUF1514 PF07438.11 PIK48836.1 - 0.13 12.2 0.1 0.36 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) GatB_N PF02934.15 PIK48837.1 - 9.3e-103 343.3 0.0 1.6e-102 342.6 0.0 1.3 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 PIK48837.1 - 3.1e-32 111.5 0.7 5.2e-32 110.8 0.7 1.4 1 0 0 1 1 1 1 GatB domain Beach PF02138.18 PIK48838.1 - 4e-124 413.4 0.3 5.4e-124 413.0 0.3 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 PIK48838.1 - 3e-18 65.8 0.0 5.5e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 PIK48838.1 - 9.3e-06 26.3 1.4 0.85 10.6 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK48838.1 - 0.0096 16.2 0.0 0.044 14.1 0.0 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SUKH_6 PF14568.6 PIK48838.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Mab-21 PF03281.14 PIK48839.1 - 1.3e-100 336.5 0.0 1.6e-100 336.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein DUF1088 PF06469.11 PIK48840.1 - 5.4e-72 241.0 5.2 1.3e-71 239.7 5.2 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) DUF639 PF04842.12 PIK48840.1 - 0.092 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF4704 PF15787.5 PIK48841.1 - 7e-97 324.0 0.8 7e-97 324.0 0.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 PIK48841.1 - 6.6e-10 39.3 0.0 1.3e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Cytomega_gL PF01801.16 PIK48841.1 - 0.059 12.7 0.2 0.24 10.8 0.1 2.1 1 1 0 1 1 1 0 Cytomegalovirus glycoprotein L GST_C_4 PF14834.6 PIK48841.1 - 0.087 13.2 0.1 1 9.8 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Pentaxin PF00354.17 PIK48841.1 - 0.088 12.5 0.1 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Pentaxin family V-ATPase_H_N PF03224.14 PIK48841.1 - 0.15 11.3 8.3 0.049 12.9 3.8 2.2 2 1 0 2 2 2 0 V-ATPase subunit H Citrate_bind PF16114.5 PIK48842.1 - 6e-37 126.9 0.1 8.4e-37 126.4 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 PIK48842.1 - 1.1e-09 38.2 0.0 1.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Moricin PF06451.11 PIK48842.1 - 0.15 11.9 1.2 0.22 11.3 0.1 1.8 2 0 0 2 2 2 0 Moricin FMO-like PF00743.19 PIK48843.1 - 9.3e-113 377.4 0.0 1.1e-112 377.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK48843.1 - 2.9e-07 30.1 0.0 0.004 16.5 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK48843.1 - 7.6e-05 22.1 0.0 0.051 12.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK48843.1 - 0.0017 17.6 0.1 5.2 6.1 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 PIK48843.1 - 0.0021 18.0 0.1 0.49 10.4 0.1 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 PIK48843.1 - 0.0052 17.0 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK48843.1 - 0.079 12.5 0.2 4.7 6.7 0.0 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 PIK48843.1 - 0.11 11.8 0.1 0.21 10.8 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Aldo_ket_red PF00248.21 PIK48844.1 - 2.5e-08 33.5 0.1 3.6e-08 32.9 0.1 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Laminin_EGF PF00053.24 PIK48845.1 - 2.8e-97 318.7 294.4 1.5e-10 41.0 14.7 17.0 16 1 1 17 17 17 16 Laminin EGF domain Laminin_N PF00055.17 PIK48845.1 - 1.3e-29 103.4 0.0 1.3e-29 103.4 0.0 4.5 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 PIK48845.1 - 1.2e-15 57.6 0.5 1.1e-14 54.4 0.0 2.5 2 0 0 2 2 2 1 Laminin B (Domain IV) PAP2_C PF14360.6 PIK48845.1 - 0.96 10.0 2.8 2 9.0 2.8 1.5 1 0 0 1 1 1 0 PAP2 superfamily C-terminal Homeodomain PF00046.29 PIK48846.1 - 1.3e-22 79.4 5.8 1.9e-22 78.9 5.8 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK48846.1 - 0.085 12.8 0.2 0.085 12.8 0.2 2.2 3 0 0 3 3 3 0 Homeobox KN domain DEAD PF00270.29 PIK48847.1 - 4.9e-49 166.5 0.0 1.4e-48 165.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK48847.1 - 1.7e-20 73.4 0.0 4.4e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK48847.1 - 9.2e-19 67.4 1.1 1.8e-18 66.5 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 PIK48847.1 - 4.9e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mur_ligase_M PF08245.12 PIK48848.1 - 1.2e-06 28.6 0.0 3.7e-05 23.8 0.0 2.4 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 PIK48848.1 - 0.015 15.6 0.0 0.041 14.1 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DUF2921 PF11145.8 PIK48848.1 - 0.18 9.6 0.0 0.27 9.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) RabGAP-TBC PF00566.18 PIK48850.1 - 7.3e-30 104.2 0.4 2.3e-29 102.6 0.2 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF3694 PF12473.8 PIK48850.1 - 3.9e-24 86.0 0.5 2e-23 83.8 0.0 2.5 2 1 0 2 2 2 1 Kinesin protein PID PF00640.23 PIK48850.1 - 0.017 15.1 0.3 0.017 15.1 0.3 2.7 2 1 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) DivIC PF04977.15 PIK48850.1 - 0.12 12.2 21.9 0.28 11.0 3.9 4.0 3 1 1 4 4 4 0 Septum formation initiator DoxX_2 PF13564.6 PIK48851.1 - 1.2e-07 31.8 1.5 2.3e-07 30.9 1.5 1.4 1 1 0 1 1 1 1 DoxX-like family DoxX PF07681.12 PIK48851.1 - 2.2e-05 24.9 0.7 3.9e-05 24.2 0.7 1.4 1 0 0 1 1 1 1 DoxX FHIPEP PF00771.20 PIK48851.1 - 0.16 10.4 0.3 0.21 10.0 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family DUF5362 PF17319.2 PIK48851.1 - 4.4 7.2 7.4 31 4.5 0.0 3.2 3 1 0 3 3 3 0 Family of unknown function (DUF5362) DUF4383 PF14325.6 PIK48852.1 - 0.0029 17.9 1.4 0.0034 17.6 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4383) DUF3533 PF12051.8 PIK48852.1 - 0.94 8.3 3.9 1.2 8.0 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3533) zf-Di19 PF05605.12 PIK48853.1 - 5.3 7.4 6.5 31 5.0 1.0 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ion_trans PF00520.31 PIK48854.1 - 6.7e-26 91.0 8.6 3.7e-19 68.9 2.6 2.3 2 0 0 2 2 2 2 Ion transport protein TRP_2 PF08344.11 PIK48854.1 - 6.5e-13 48.7 0.2 1.9e-12 47.2 0.1 1.9 2 0 0 2 2 2 1 Transient receptor ion channel II Ank_2 PF12796.7 PIK48854.1 - 1.5e-11 44.7 0.7 1.5e-06 28.7 0.1 2.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK48854.1 - 5.4e-11 42.8 0.2 3.6e-07 30.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK48854.1 - 3.3e-09 36.2 0.8 0.023 15.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK48854.1 - 1e-08 35.2 0.4 0.00069 19.9 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK48854.1 - 1.9e-05 24.9 0.3 0.13 12.7 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat PKD_channel PF08016.12 PIK48854.1 - 0.00023 20.0 10.7 0.1 11.3 5.9 2.4 2 1 0 2 2 2 2 Polycystin cation channel ApoLp-III PF07464.11 PIK48854.1 - 0.095 12.8 0.3 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Cytochrom_B562 PF07361.11 PIK48854.1 - 0.47 11.1 1.9 3.3 8.4 0.0 2.8 2 1 1 3 3 3 0 Cytochrome b562 Atthog PF18800.1 PIK48855.1 - 1.1e-35 122.6 1.1 1.5e-35 122.2 1.1 1.1 1 0 0 1 1 1 1 Attenuator of Hedgehog DUF998 PF06197.13 PIK48855.1 - 0.0068 16.0 7.4 0.0068 16.0 7.4 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF998) Claudin_3 PF06653.11 PIK48855.1 - 0.014 15.3 2.6 0.014 15.3 2.6 2.2 2 1 0 2 2 2 0 Tight junction protein, Claudin-like Peptidase_U4 PF03419.13 PIK48855.1 - 0.55 9.5 0.0 0.55 9.5 0.0 2.1 1 1 1 2 2 2 0 Sporulation factor SpoIIGA Transferrin PF00405.17 PIK48856.1 - 5.5e-45 154.0 0.0 6.7e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Transferrin DUF2828 PF11443.8 PIK48856.1 - 4.9 5.1 11.2 6.1 4.8 11.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NPR3 PF03666.13 PIK48856.1 - 5.6 5.6 10.2 6.9 5.3 10.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Transferrin PF00405.17 PIK48857.1 - 2.4e-69 234.0 0.4 3.4e-63 213.8 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 PIK48857.1 - 1.6e-08 34.5 0.0 0.00042 20.0 0.0 2.2 2 0 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein Fibrinogen_C PF00147.18 PIK48858.1 - 2e-42 145.5 6.0 2.3e-42 145.3 6.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Arteri_env PF01606.16 PIK48859.1 - 0.083 12.7 5.4 0.12 12.2 5.4 1.2 1 0 0 1 1 1 0 Arterivirus envelope protein Mito_carr PF00153.27 PIK48860.1 - 1.4e-52 175.6 5.4 1.2e-22 79.6 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK48860.1 - 0.0019 17.4 2.4 0.37 9.9 0.1 3.2 3 1 1 4 4 4 2 Gammaproteobacterial serine protease Pro_isomerase PF00160.21 PIK48861.1 - 2.1e-48 164.6 0.1 2.5e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Transferrin PF00405.17 PIK48862.1 - 3.9e-148 493.0 0.3 2.2e-77 260.4 0.0 2.1 1 1 1 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 PIK48862.1 - 7.7e-17 61.7 0.0 2.4e-06 27.3 0.0 3.2 2 1 1 3 3 3 3 ABC transporter, phosphonate, periplasmic substrate-binding protein Peptidase_M2 PF01401.18 PIK48863.1 - 0 1162.9 18.3 7.6e-217 721.4 0.6 3.1 2 1 1 3 3 3 3 Angiotensin-converting enzyme Thg1 PF04446.12 PIK48863.1 - 0.82 9.7 5.3 2 8.4 0.3 2.5 2 0 0 2 2 2 0 tRNAHis guanylyltransferase Peptidase_M2 PF01401.18 PIK48864.1 - 2e-35 122.5 0.0 2.6e-35 122.1 0.0 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Integrase_H2C2 PF17921.1 PIK48865.1 - 4.6e-15 55.5 0.7 8e-15 54.7 0.7 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK48865.1 - 1.4e-11 44.3 0.1 2.2e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4910 PF16254.5 PIK48865.1 - 0.093 11.6 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4910) SET PF00856.28 PIK48866.1 - 3.9e-08 33.9 0.5 9.1e-07 29.4 0.0 2.6 2 1 0 2 2 2 1 SET domain CENP-B_dimeris PF09026.10 PIK48867.1 - 0.034 14.5 2.1 0.034 14.5 2.1 3.2 1 1 2 3 3 3 0 Centromere protein B dimerisation domain zf-CCHC PF00098.23 PIK48868.1 - 1.4e-06 28.0 16.2 0.00081 19.4 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK48868.1 - 0.0012 18.7 8.2 0.13 12.1 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK48868.1 - 0.0089 16.0 12.8 0.29 11.1 1.2 3.5 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK48868.1 - 0.027 14.3 0.2 0.027 14.3 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK48868.1 - 0.028 14.2 0.8 0.028 14.2 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK48868.1 - 0.064 13.0 11.1 6.1 6.7 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle DUF1736 PF08409.11 PIK48871.1 - 0.0022 17.9 14.2 12 6.0 0.3 6.5 1 1 6 7 7 7 2 Domain of unknown function (DUF1736) Myf5 PF12232.8 PIK48871.1 - 0.11 13.3 13.2 1.2e+02 3.6 0.1 6.4 7 0 0 7 7 7 0 Myogenic determination factor 5 FAM150 PF15129.6 PIK48871.1 - 1.5 9.0 6.6 46 4.2 0.3 3.7 1 1 4 5 5 5 0 FAM150 family STAT6_C PF14596.6 PIK48871.1 - 8.8 6.3 11.3 11 6.0 0.1 4.4 1 1 2 3 3 3 0 STAT6 C-terminal RVT_1 PF00078.27 PIK48872.1 - 9.5e-16 58.0 0.0 1.5e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) fn3 PF00041.21 PIK48874.1 - 2.5e-27 95.0 12.2 6.2e-11 42.5 0.0 5.2 5 0 0 5 5 5 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK48874.1 - 5.1e-06 27.0 5.6 0.022 15.3 0.2 4.1 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 PIK48874.1 - 0.00012 22.2 0.3 0.00056 20.1 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 PIK48874.1 - 0.0012 18.8 1.1 0.14 12.1 0.7 3.7 2 1 0 2 2 2 1 Ig-like C2-type domain Ig_3 PF13927.6 PIK48874.1 - 0.043 14.4 1.3 0.24 12.0 0.2 2.8 2 0 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 PIK48874.1 - 0.057 13.8 0.3 0.2 12.0 0.3 2.0 1 0 0 1 1 1 0 Immunoglobulin domain fn3 PF00041.21 PIK48875.1 - 9.5e-10 38.7 0.2 2e-09 37.7 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Tissue_fac PF01108.17 PIK48875.1 - 0.00056 19.7 2.2 0.0012 18.7 0.0 2.2 2 1 0 2 2 2 1 Tissue factor GPI-anchored PF10342.9 PIK48875.1 - 0.054 14.3 0.1 0.12 13.1 0.1 1.5 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SRCR PF00530.18 PIK48876.1 - 7.8e-30 103.3 1.4 9.1e-30 103.1 1.4 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48876.1 - 1.1e-05 25.9 0.5 1.6e-05 25.3 0.2 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK48877.1 - 2.7e-24 85.6 1.2 2.7e-24 85.6 1.2 2.1 3 0 0 3 3 3 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48877.1 - 6.5e-05 23.4 0.1 6.5e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48877.1 - 0.018 15.5 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 Hepsin, SRCR domain SRCR PF00530.18 PIK48878.1 - 5e-109 357.5 18.0 4.8e-28 97.6 0.4 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48878.1 - 1.4e-24 86.5 6.2 0.0001 22.8 0.1 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48878.1 - 5.3e-15 55.9 0.1 0.017 15.6 0.0 4.4 4 0 0 4 4 4 4 Hepsin, SRCR domain TPKR_C2 PF16920.5 PIK48878.1 - 0.0002 21.4 2.6 2.8 8.1 0.1 3.5 3 0 0 3 3 3 3 Tyrosine-protein kinase receptor C2 Ig-like domain Fz PF01392.22 PIK48878.1 - 0.0029 18.2 0.1 0.012 16.2 0.1 2.2 1 0 0 1 1 1 1 Fz domain YecR PF13992.6 PIK48878.1 - 0.25 11.7 5.7 22 5.4 0.5 4.8 4 2 0 4 4 4 0 YecR-like lipoprotein SRCR PF00530.18 PIK48879.1 - 7.7e-29 100.1 9.6 1.3e-23 83.3 0.2 2.6 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain Fz PF01392.22 PIK48879.1 - 2.6e-19 69.9 1.1 7e-19 68.5 1.1 1.8 1 0 0 1 1 1 1 Fz domain SRCR_2 PF15494.6 PIK48879.1 - 3.3e-07 30.8 0.0 1.1e-06 29.1 0.1 1.8 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48879.1 - 0.0016 18.9 0.2 0.014 15.9 0.2 2.2 1 1 1 2 2 2 1 Hepsin, SRCR domain SRCR PF00530.18 PIK48880.1 - 6.7e-54 180.6 9.9 1.4e-27 96.1 0.4 2.7 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain RVT_1 PF00078.27 PIK48880.1 - 7.9e-19 68.0 0.0 1.2e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SRCR_2 PF15494.6 PIK48880.1 - 9.6e-13 48.5 2.1 4.1e-05 24.0 0.1 2.7 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48880.1 - 5.4e-08 33.3 0.4 0.0048 17.4 0.1 2.8 2 1 0 2 2 2 2 Hepsin, SRCR domain SRCR PF00530.18 PIK48882.1 - 2.2e-30 105.1 0.5 2.5e-30 104.9 0.5 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48882.1 - 1.4e-05 25.5 0.2 1.6e-05 25.3 0.2 1.3 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48882.1 - 0.01 16.3 0.0 0.011 16.3 0.0 1.4 1 1 0 1 1 1 0 Hepsin, SRCR domain PEP-utilizers PF00391.23 PIK48882.1 - 0.029 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain TPKR_C2 PF16920.5 PIK48882.1 - 0.037 14.2 0.3 0.062 13.4 0.3 1.3 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain SRCR PF00530.18 PIK48883.1 - 0 1006.5 81.1 9.4e-29 99.9 0.7 12.0 12 0 0 12 12 12 12 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK48883.1 - 1.1e-64 215.0 26.6 9.4e-08 32.5 0.1 11.3 11 0 0 11 11 11 11 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK48883.1 - 4.4e-36 123.7 0.5 0.066 13.7 0.0 11.4 11 0 0 11 11 11 10 Hepsin, SRCR domain PEP-utilizers PF00391.23 PIK48883.1 - 4.3e-17 61.6 1.3 0.89 9.3 0.0 6.8 7 0 0 7 7 7 6 PEP-utilising enzyme, mobile domain TcfC PF16967.5 PIK48883.1 - 3.1e-06 26.6 7.2 40 3.8 0.0 7.3 7 0 0 7 7 7 0 E-set like domain CBM_6 PF03422.15 PIK48883.1 - 0.1 12.9 0.3 27 5.1 0.0 5.1 8 0 0 8 8 8 0 Carbohydrate binding module (family 6) NifQ PF04891.12 PIK48884.1 - 4.1 7.7 6.9 32 4.8 0.2 3.1 1 1 3 4 4 4 0 NifQ HTH_15 PF12324.8 PIK48885.1 - 0.00096 19.1 5.1 4.9 7.2 0.1 3.7 4 0 0 4 4 4 3 Helix-turn-helix domain of alkylmercury lyase Mrr_cat_2 PF13156.6 PIK48885.1 - 4.3 7.3 13.3 3.9 7.4 0.3 3.8 2 1 2 4 4 4 0 Restriction endonuclease SPT6_acidic PF14632.6 PIK48886.1 - 5.4 7.7 8.3 19 5.9 8.3 2.0 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Thioredoxin_7 PF13899.6 PIK48887.1 - 6e-11 42.4 0.0 7.6e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 PIK48887.1 - 0.00011 22.2 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 PIK48887.1 - 0.002 18.6 0.0 0.0023 18.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.15 PIK48887.1 - 0.0026 17.7 0.0 0.0028 17.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF255 AhpC-TSA PF00578.21 PIK48887.1 - 0.061 13.2 0.0 0.069 13.1 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 PIK48887.1 - 0.12 12.7 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 PIK48887.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin hDGE_amylase PF14701.6 PIK48888.1 - 4.2e-122 408.4 0.7 5.8e-122 408.0 0.7 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain hGDE_central PF14702.6 PIK48888.1 - 1.1e-37 130.1 0.0 2.1e-37 129.2 0.0 1.5 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme Alpha-amylase PF00128.24 PIK48888.1 - 0.0087 15.7 0.1 0.067 12.7 0.0 2.3 3 0 0 3 3 3 1 Alpha amylase, catalytic domain EF-hand_1 PF00036.32 PIK48889.1 - 8.2e-20 68.8 9.5 3.1e-06 26.3 0.0 5.4 6 0 0 6 6 6 3 EF hand EF-hand_7 PF13499.6 PIK48889.1 - 4.5e-19 68.7 4.2 9.3e-13 48.4 0.3 3.7 4 0 0 4 4 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK48889.1 - 6.1e-16 56.9 6.6 4.5e-06 26.2 0.0 5.9 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 PIK48889.1 - 3.6e-15 54.7 6.5 5e-07 28.9 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK48889.1 - 8.7e-13 47.9 10.7 5.5e-11 42.1 0.3 3.9 3 1 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK48889.1 - 3.9e-05 23.9 3.4 0.00031 21.0 0.1 3.2 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK48889.1 - 0.00016 21.5 1.7 0.067 13.1 0.0 3.2 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF_assoc_2 PF08356.12 PIK48889.1 - 0.00017 21.5 0.0 0.00056 19.8 0.0 1.8 1 0 0 1 1 1 1 EF hand associated EFhand_Ca_insen PF08726.10 PIK48889.1 - 0.00081 19.4 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_9 PF14658.6 PIK48889.1 - 0.03 14.7 0.1 0.58 10.5 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 PIK48889.1 - 0.08 13.1 0.3 1.7 8.9 0.0 2.6 1 1 1 2 2 2 0 Dockerin type I domain TMEM215 PF15746.5 PIK48889.1 - 0.35 10.3 0.0 0.35 10.3 0.0 2.4 3 1 1 4 4 4 0 TMEM215 family RNB PF00773.19 PIK48889.1 - 0.53 9.6 7.0 0.44 9.8 3.6 2.1 1 1 1 2 2 2 0 RNB domain 7tm_1 PF00001.21 PIK48890.1 - 4.5e-36 124.5 11.5 5.3e-36 124.3 11.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK48890.1 - 2.9e-06 26.9 10.1 3.7e-06 26.5 10.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK48890.1 - 2e-05 24.1 9.2 0.00035 20.0 9.2 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK48890.1 - 6.4e-05 22.4 2.5 6.4e-05 22.4 2.5 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK48890.1 - 0.0004 20.1 4.4 0.0004 20.1 4.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF3810 PF12725.7 PIK48890.1 - 1.2 8.5 6.5 0.093 12.1 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) RVT_1 PF00078.27 PIK48891.1 - 1.9e-30 106.1 0.0 2.5e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flu_PB1 PF00602.17 PIK48891.1 - 0.11 10.6 0.0 0.13 10.3 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Gemini_C4 PF01492.17 PIK48891.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Geminivirus C4 protein HYR PF02494.16 PIK48894.1 - 5.1e-28 97.2 10.3 6.6e-14 52.0 0.4 3.5 3 0 0 3 3 3 3 HYR domain Sushi PF00084.20 PIK48894.1 - 2.3e-11 44.1 15.2 1.9e-06 28.4 5.0 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) DUF982 PF06169.12 PIK48894.1 - 0.04 14.0 0.2 0.73 9.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF982) cEGF PF12662.7 PIK48894.1 - 1.8 8.6 8.4 3.8 7.5 1.0 3.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like zf-B_box PF00643.24 PIK48895.1 - 3.8e-13 49.4 18.7 1.1e-11 44.7 4.5 2.3 2 0 0 2 2 2 2 B-box zinc finger Apolipoprotein PF01442.18 PIK48895.1 - 0.00043 20.2 1.9 0.0006 19.7 1.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain JIP_LZII PF16471.5 PIK48895.1 - 0.08 13.1 5.6 0.16 12.2 1.7 2.8 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Cnn_1N PF07989.11 PIK48895.1 - 0.089 13.0 2.4 0.29 11.3 2.1 2.1 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Laminin_II PF06009.12 PIK48895.1 - 0.34 10.9 8.4 0.039 14.0 2.6 2.2 2 1 1 3 3 3 0 Laminin Domain II DUF883 PF05957.13 PIK48895.1 - 0.53 10.9 2.5 0.51 11.0 0.7 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ribosomal_S20p PF01649.18 PIK48895.1 - 1.4 9.6 6.9 4.1 8.1 3.2 2.7 2 1 1 3 3 3 0 Ribosomal protein S20 FlaC_arch PF05377.11 PIK48895.1 - 5.8 7.4 7.8 3.4 8.1 1.3 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) IBR PF01485.21 PIK48895.1 - 7.1 6.9 13.8 2.2 8.6 3.4 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain HIP1_clath_bdg PF16515.5 PIK48895.1 - 9.2 6.9 9.2 1.6 9.4 3.4 2.5 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MFS_1 PF07690.16 PIK48896.1 - 4.1e-16 58.9 16.9 6.1e-10 38.5 2.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PDZ PF00595.24 PIK48897.1 - 4.9e-58 193.5 15.6 4.8e-17 62.1 0.2 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK48897.1 - 3.5e-25 87.6 2.8 1.3e-06 28.1 0.0 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK48897.1 - 5.3e-25 87.6 8.9 3.4e-08 33.7 0.2 4.3 4 0 0 4 4 4 4 PDZ domain zf-TRAF PF02176.18 PIK48897.1 - 1.8e-07 31.7 2.4 5.5e-07 30.2 2.4 1.8 1 0 0 1 1 1 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 PIK48897.1 - 8.6e-07 28.7 8.3 8.6e-07 28.7 8.3 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK48897.1 - 6.2e-06 26.0 7.4 6.2e-06 26.0 7.4 3.6 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK48897.1 - 3.2e-05 23.8 4.6 3.2e-05 23.8 4.6 3.6 4 0 0 4 4 4 1 zinc-RING finger domain Tricorn_PDZ PF14685.6 PIK48897.1 - 3.2e-05 23.8 1.0 1.9 8.5 0.0 4.3 4 0 0 4 4 4 1 Tricorn protease PDZ domain zf-RING_2 PF13639.6 PIK48897.1 - 9.6e-05 22.6 5.9 9.6e-05 22.6 5.9 3.4 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK48897.1 - 0.00013 21.9 7.0 0.00013 21.9 7.0 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK48897.1 - 0.00027 20.7 4.0 0.00027 20.7 4.0 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) PDZ_4 PF17816.1 PIK48897.1 - 0.001 19.5 0.3 9.6 6.6 0.0 4.0 4 0 0 4 4 4 0 PDZ domain zf-C3HC4_4 PF15227.6 PIK48897.1 - 0.001 19.1 6.0 0.001 19.1 6.0 3.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING Phage_tail_APC PF16778.5 PIK48897.1 - 0.0089 15.9 0.1 12 5.8 0.0 3.3 3 0 0 3 3 3 0 Phage tail assembly chaperone protein Sina PF03145.16 PIK48897.1 - 0.011 15.6 0.9 0.025 14.6 0.9 1.5 1 0 0 1 1 1 0 Seven in absentia protein family LIME1 PF15332.6 PIK48897.1 - 0.072 12.7 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Lck-interacting transmembrane adapter 1 Lys-AminoMut_A PF09043.11 PIK48897.1 - 0.085 11.3 0.2 0.12 10.8 0.2 1.1 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit zf-rbx1 PF12678.7 PIK48897.1 - 0.14 12.5 12.0 0.036 14.4 7.1 2.7 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 PIK48897.1 - 5.8 7.1 13.0 1.8 8.8 5.4 3.2 2 1 1 3 3 3 0 zinc RING finger of MSL2 rve PF00665.26 PIK48898.1 - 1.2e-21 77.1 0.0 2.1e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK48898.1 - 0.012 15.4 0.0 0.031 14.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 PIK48899.1 - 1e-37 128.2 0.0 3.8e-37 126.3 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48899.1 - 1.8e-33 115.0 0.0 5.1e-33 113.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK48899.1 - 2.4e-32 112.3 0.0 4.2e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK48899.1 - 1.4e-05 24.9 4.0 1.4e-05 24.9 4.0 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK48899.1 - 0.12 12.2 2.2 0.32 10.9 2.2 1.8 1 0 0 1 1 1 0 Zinc knuckle Myofilin PF15929.5 PIK48900.1 - 0.0038 17.6 0.3 0.0061 17.0 0.3 1.4 1 0 0 1 1 1 1 Myofilin Retrotrans_gag PF03732.17 PIK48901.1 - 0.021 15.1 0.1 0.31 11.3 0.0 2.4 2 1 1 3 3 3 0 Retrotransposon gag protein AAA_lid_5 PF17865.1 PIK48901.1 - 0.033 14.3 0.1 0.1 12.7 0.1 1.8 1 0 0 1 1 1 0 Midasin AAA lid domain RVT_1 PF00078.27 PIK48902.1 - 0.0053 16.3 0.1 0.008 15.7 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK48903.1 - 6.7e-37 125.5 0.0 1.3e-36 124.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK48903.1 - 1.5e-33 115.2 0.0 3e-33 114.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK48903.1 - 2.1e-22 79.5 0.0 3.7e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK48903.1 - 3e-14 52.8 0.0 8e-14 51.5 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK48903.1 - 0.0018 17.8 0.0 0.0036 16.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK48903.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK48903.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 DDE domain adh_short PF00106.25 PIK48905.1 - 1.2e-34 119.4 0.1 8e-34 116.8 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK48905.1 - 1.3e-22 80.6 0.0 4e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK48905.1 - 1.1e-10 41.8 0.0 1.5e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 KR domain PARP PF00644.20 PIK48906.1 - 6.3e-72 241.3 0.0 7.4e-72 241.0 0.0 1.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain 7tm_1 PF00001.21 PIK48907.1 - 1.9e-35 122.4 22.2 2.5e-35 122.1 22.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-PARP PF00645.18 PIK48908.1 - 9.3e-39 132.2 8.4 3.3e-19 69.5 1.6 2.4 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Med27 PF11571.8 PIK48908.1 - 0.057 13.8 1.2 3.6 8.0 0.6 2.3 2 0 0 2 2 2 0 Mediator complex subunit 27 DiS_P_DiS PF06750.13 PIK48908.1 - 0.14 12.3 1.3 12 6.1 0.3 2.2 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain TRP_2 PF08344.11 PIK48908.1 - 0.47 10.7 3.8 15 5.9 0.5 2.4 2 0 0 2 2 2 0 Transient receptor ion channel II Thioredoxin_9 PF14595.6 PIK48910.1 - 0.46 10.3 8.7 55 3.5 0.0 5.2 5 0 0 5 5 5 0 Thioredoxin Annexin PF00191.20 PIK48911.1 - 1.4e-42 143.6 6.7 9.6e-17 60.8 0.0 4.5 4 0 0 4 4 4 4 Annexin KIAA1430 PF13879.6 PIK48911.1 - 9.9e-18 64.8 10.7 9.9e-18 64.8 10.7 3.8 3 1 0 3 3 3 1 KIAA1430 homologue FACT-Spt16_Nlob PF14826.6 PIK48912.1 - 0.014 15.2 0.2 0.03 14.1 0.2 1.5 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain EGF PF00008.27 PIK48914.1 - 1.9e-19 69.6 71.9 9.3e-06 25.8 3.8 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_CA PF07645.15 PIK48914.1 - 1.8e-07 31.2 8.5 1.8e-07 31.2 8.5 6.6 4 2 2 6 6 6 3 Calcium-binding EGF domain Pacifastin_I PF05375.13 PIK48914.1 - 2.3e-06 27.2 4.6 2.3e-06 27.2 4.6 5.4 6 2 0 6 6 4 1 Pacifastin inhibitor (LCMII) hEGF PF12661.7 PIK48914.1 - 5.8e-06 26.7 57.2 0.0083 16.7 4.9 6.9 6 0 0 6 6 6 4 Human growth factor-like EGF EGF_2 PF07974.13 PIK48914.1 - 1.6e-05 25.1 75.8 0.0067 16.8 8.3 6.2 5 1 1 6 6 6 4 EGF-like domain TMEM154 PF15102.6 PIK48914.1 - 0.02 14.8 0.1 0.042 13.7 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family VWC PF00093.18 PIK48914.1 - 0.025 14.9 4.8 0.025 14.9 4.8 5.9 3 1 1 4 4 1 0 von Willebrand factor type C domain DUF4834 PF16118.5 PIK48914.1 - 0.025 15.5 0.1 0.13 13.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Tmemb_9 PF05434.11 PIK48914.1 - 0.025 14.4 0.3 0.025 14.4 0.3 1.9 2 0 0 2 2 1 0 TMEM9 EphA2_TM PF14575.6 PIK48914.1 - 0.028 15.3 1.0 0.028 15.3 1.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_C_2 PF16492.5 PIK48914.1 - 0.14 12.9 0.2 0.79 10.5 0.0 2.2 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal TraL PF07178.11 PIK48914.1 - 0.16 12.4 0.1 0.36 11.3 0.1 1.5 1 0 0 1 1 1 0 TraL protein Gemini_mov PF01708.16 PIK48914.1 - 0.27 11.0 1.2 3.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Geminivirus putative movement protein LRRC37AB_C PF14914.6 PIK48914.1 - 0.65 9.9 3.0 0.39 10.6 0.2 2.0 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain LapA_dom PF06305.11 PIK48914.1 - 2.8 7.8 3.6 0.74 9.7 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Myb_DNA-binding PF00249.31 PIK48915.1 - 5.4e-07 29.7 0.2 2.4e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 PIK48915.1 - 0.00033 20.4 8.7 0.00066 19.4 8.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 PIK48915.1 - 0.0011 19.1 0.0 0.0039 17.4 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-B_box PF00643.24 PIK48915.1 - 1.5 9.0 8.1 14 6.0 1.7 2.4 1 1 1 2 2 2 0 B-box zinc finger Med17 PF10156.9 PIK48916.1 - 3.7e-09 35.8 1.8 3.7e-09 35.8 1.8 2.1 2 0 0 2 2 2 2 Subunit 17 of Mediator complex DUF3224 PF11528.8 PIK48916.1 - 0.15 11.9 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3224) Tyr_Deacylase PF02580.16 PIK48917.1 - 2.9e-32 112.2 0.0 3.3e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ABC_tran PF00005.27 PIK48918.1 - 1e-06 29.3 0.0 2.2e-06 28.2 0.0 1.5 2 0 0 2 2 2 1 ABC transporter ABC_membrane_2 PF06472.15 PIK48919.1 - 2e-62 211.0 5.6 2.8e-62 210.6 5.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 B9-C2 PF07162.11 PIK48920.1 - 1.8e-56 191.0 0.0 2.5e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Phlebovirus_G2 PF07245.11 PIK48920.1 - 0.036 12.6 0.0 0.047 12.2 0.0 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 Tyr-DNA_phospho PF06087.12 PIK48921.1 - 4.3e-126 421.3 2.9 5.1e-126 421.0 2.9 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase zf-CCHH PF10283.9 PIK48921.1 - 1.2e-06 28.4 5.8 3.2e-06 27.0 5.8 1.7 1 0 0 1 1 1 1 PBZ domain Cadherin_3 PF16184.5 PIK48921.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Cadherin-like ARID PF01388.21 PIK48922.1 - 1e-23 83.8 0.4 3.2e-23 82.2 0.2 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain RBB1NT PF08169.11 PIK48922.1 - 4.1e-16 58.9 0.1 1.2e-15 57.5 0.1 1.8 1 0 0 1 1 1 1 RBB1NT (NUC162) domain Tudor_2 PF18104.1 PIK48922.1 - 0.00047 19.8 0.3 0.0035 17.0 0.1 2.4 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain Agenet PF05641.12 PIK48922.1 - 0.00081 19.8 0.4 0.2 12.2 0.1 2.6 2 0 0 2 2 2 1 Agenet domain TUDOR_5 PF18359.1 PIK48922.1 - 0.0039 16.9 0.0 0.051 13.3 0.0 2.4 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain 1 Tudor_3 PF18115.1 PIK48922.1 - 0.017 15.0 0.4 3.2 7.7 0.0 3.1 3 0 0 3 3 3 0 DNA repair protein Crb2 Tudor domain 53-BP1_Tudor PF09038.10 PIK48922.1 - 0.038 14.0 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor TUDOR PF00567.24 PIK48922.1 - 0.058 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Tudor domain Rad9_Rad53_bind PF08605.10 PIK48922.1 - 0.061 13.5 0.3 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding DUF4537 PF15057.6 PIK48922.1 - 0.083 12.9 0.1 0.48 10.5 0.0 2.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4537) Cytomega_UL84 PF06284.11 PIK48922.1 - 1.4 7.3 5.4 2 6.8 5.4 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein HsdM_N PF12161.8 PIK48922.1 - 2.1 9.0 9.8 1.3 9.6 0.1 2.9 2 1 0 3 3 2 0 HsdM N-terminal domain THOC2_N PF16134.5 PIK48923.1 - 0.0024 16.6 0.0 0.0024 16.6 0.0 1.0 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus GrpE PF01025.19 PIK48923.1 - 0.049 13.3 0.7 0.053 13.2 0.7 1.1 1 0 0 1 1 1 0 GrpE PC4 PF02229.16 PIK48924.1 - 3.5e-24 84.2 0.4 5.5e-24 83.5 0.4 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) DTHCT PF08070.11 PIK48924.1 - 0.0074 17.0 7.5 0.011 16.4 7.5 1.3 1 0 0 1 1 1 1 DTHCT (NUC029) region 7tm_1 PF00001.21 PIK48925.1 - 4.9e-40 137.5 10.9 6.8e-40 137.1 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 PIK48925.1 - 0.0088 15.8 14.2 0.034 13.9 12.3 2.2 1 1 1 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Zip PF02535.22 PIK48925.1 - 0.38 9.9 7.3 0.076 12.2 2.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Methyltransf_25 PF13649.6 PIK48926.1 - 0.035 14.8 0.0 0.079 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Bcl-2 PF00452.19 PIK48927.1 - 2.7e-14 53.6 1.9 4.7e-14 52.9 1.0 1.9 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family Arc_PepC_II PF06847.11 PIK48927.1 - 0.13 12.8 0.2 0.41 11.2 0.1 1.9 1 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Treslin_N PF15292.6 PIK48928.1 - 2.7e-21 75.7 36.6 3.4e-10 39.0 12.5 3.4 2 2 0 2 2 2 2 Treslin N-terminus GlutR_dimer PF00745.20 PIK48928.1 - 0.008 16.6 0.2 0.032 14.7 0.2 2.1 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain DUF679 PF05078.12 PIK48928.1 - 0.17 11.8 0.7 0.31 11.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF679) Lig_chan PF00060.26 PIK48929.1 - 1.1e-28 100.0 0.2 1.4e-28 99.6 0.2 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK48929.1 - 1.3e-21 76.9 0.0 2.3e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 PIK48929.1 - 1.7e-11 44.0 0.0 6.3e-11 42.1 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 PIK48930.1 - 3.6e-21 75.7 0.1 5.8e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 PIK48930.1 - 9.4e-21 74.1 0.0 1.8e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 PIK48930.1 - 7.7e-20 71.2 0.2 1.4e-19 70.4 0.2 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK48930.1 - 1.3e-11 44.4 0.0 3.1e-07 30.1 0.0 2.6 2 1 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 PIK48931.1 - 2.3e-16 59.9 0.0 3.5e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 PIK48931.1 - 5.4e-13 49.0 0.2 9.5e-13 48.2 0.2 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK48931.1 - 8.5e-11 42.1 0.0 1.8e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 PIK48932.1 - 9.6e-24 83.9 0.2 1.9e-23 83.0 0.2 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 PIK48932.1 - 1.5e-18 67.0 0.0 3.2e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 PIK48932.1 - 1e-17 64.3 0.2 1.7e-17 63.6 0.2 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 PIK48932.1 - 2.3e-09 37.1 0.0 7.6e-09 35.3 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ndr PF03096.14 PIK48932.1 - 0.02 13.6 0.0 0.032 12.9 0.0 1.2 1 0 0 1 1 1 0 Ndr family Lig_chan-Glu_bd PF10613.9 PIK48933.1 - 1.3e-33 115.6 0.0 2.8e-33 114.5 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 PIK48933.1 - 2.8e-26 92.1 0.7 5.6e-26 91.2 0.5 1.6 2 0 0 2 2 2 1 Ligand-gated ion channel ANF_receptor PF01094.28 PIK48933.1 - 1.7e-24 86.6 0.0 2.7e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 PIK48933.1 - 2e-17 63.4 0.0 4.4e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 PIK48933.1 - 0.0014 18.5 3.7 0.0042 17.0 3.7 1.8 1 0 0 1 1 1 1 Ion channel DRTGG PF07085.12 PIK48933.1 - 0.13 12.0 0.0 0.49 10.2 0.0 1.9 2 0 0 2 2 2 0 DRTGG domain ADH_N PF08240.12 PIK48935.1 - 4e-30 103.9 1.1 4e-30 103.9 1.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK48935.1 - 1e-22 80.5 0.0 1.8e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK48935.1 - 1.6e-07 31.1 0.0 3.4e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK48935.1 - 9.1e-05 21.9 0.1 0.00016 21.1 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 PIK48935.1 - 0.0001 23.4 0.0 0.00019 22.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 PIK48935.1 - 0.0042 16.3 0.1 0.0084 15.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 PIK48935.1 - 0.059 12.7 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 PIK48935.1 - 0.074 13.3 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_3 PF13738.6 PIK48935.1 - 0.085 12.1 0.5 0.14 11.4 0.5 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPR_1 PF00515.28 PIK48936.1 - 6.4e-15 54.3 1.7 0.0003 20.5 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 PIK48936.1 - 6.5e-13 48.8 0.0 2.1e-12 47.2 0.0 1.9 2 0 0 2 2 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.6 PIK48936.1 - 1.5e-12 47.0 0.2 0.0039 16.9 0.0 3.6 4 0 0 4 4 4 3 TPR repeat TPR_2 PF07719.17 PIK48936.1 - 2.6e-12 45.8 1.4 0.00033 20.6 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK48936.1 - 7.2e-09 35.2 1.7 0.055 13.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK48936.1 - 5.9e-06 26.7 0.0 0.73 10.8 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat DUF3856 PF12968.7 PIK48936.1 - 8.8e-05 22.6 0.2 0.00027 21.0 0.2 1.9 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 PIK48936.1 - 0.00017 22.0 0.2 0.0046 17.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK48936.1 - 0.00029 21.0 0.1 0.036 14.5 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK48936.1 - 0.00035 21.2 0.1 0.034 14.8 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK48936.1 - 0.00042 20.4 0.0 0.00082 19.5 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK48936.1 - 0.0051 16.8 0.0 5.8 7.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK48936.1 - 0.0057 15.6 1.5 0.0057 15.6 1.5 2.4 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 HMMR_C PF15908.5 PIK48936.1 - 0.006 16.9 2.5 0.006 16.9 2.5 2.8 2 1 1 3 3 2 1 Hyaluronan mediated motility receptor C-terminal Fis1_TPR_C PF14853.6 PIK48936.1 - 0.033 14.3 2.3 0.22 11.6 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 PIK48936.1 - 0.091 13.2 0.0 0.43 11.0 0.0 2.0 1 1 1 2 2 2 0 Bacterial transcriptional activator domain DUF768 PF05589.11 PIK48936.1 - 0.16 12.0 0.6 1 9.4 0.0 2.7 2 0 0 2 2 1 0 Protein of unknown function (DUF768) Pet100 PF09803.9 PIK48936.1 - 9.2 6.9 7.1 0.72 10.4 0.4 2.4 2 0 0 2 2 2 0 Pet100 Hydrolase_4 PF12146.8 PIK48937.1 - 9e-13 48.0 0.0 3.8e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK48937.1 - 4e-06 27.6 0.1 7.6e-06 26.7 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 PIK48937.1 - 1.3e-05 24.8 0.0 0.00035 20.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 PIK48937.1 - 6.1e-05 22.8 0.2 0.11 12.1 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 PIK48937.1 - 0.0012 18.5 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 PIK48937.1 - 0.01 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Asp2 PF16929.5 PIK48937.1 - 0.019 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_2 PF02230.16 PIK48937.1 - 0.065 13.0 0.0 0.24 11.2 0.0 1.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF818 PF05677.12 PIK48937.1 - 0.073 12.0 0.1 0.1 11.5 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.12 PIK48937.1 - 0.075 13.0 0.0 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Med26 PF08711.11 PIK48938.1 - 9.7e-13 47.9 4.2 1.8e-12 47.1 4.2 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ku_C PF03730.14 PIK48938.1 - 0.47 11.2 4.1 0.85 10.4 3.5 1.7 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm TFIIS_M PF07500.14 PIK48939.1 - 3e-25 88.9 0.5 4.5e-25 88.3 0.5 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 PIK48939.1 - 3.2e-18 65.3 7.5 4.7e-18 64.8 7.5 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) zf-ribbon_3 PF13248.6 PIK48939.1 - 0.074 12.5 3.0 4 7.0 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 PIK48939.1 - 0.099 12.2 2.3 0.24 10.9 2.3 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 PIK48939.1 - 0.25 11.3 3.7 4.4 7.3 4.0 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 PIK48939.1 - 1.4 8.8 10.9 2.7 7.8 0.8 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 PIK48939.1 - 1.8 8.3 4.7 0.75 9.5 0.4 2.2 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain IBR PF01485.21 PIK48939.1 - 3.4 8.0 9.3 18 5.7 9.3 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain SYCP2_SLD PF18584.1 PIK48941.1 - 2.1e-19 69.8 0.3 5e-19 68.6 0.3 1.6 1 0 0 1 1 1 1 Synaptonemal complex 2 Spt16M-like domain SYCP2_ARLD PF18581.1 PIK48941.1 - 1.5e-15 57.7 4.2 2.8e-15 56.7 4.2 1.5 1 0 0 1 1 1 1 Synaptonemal complex 2 armadillo-repeat-like domain Cor1 PF04803.12 PIK48941.1 - 3.8e-07 30.4 8.7 3.8e-07 30.4 8.7 3.2 3 0 0 3 3 3 1 Cor1/Xlr/Xmr conserved region Pkinase PF00069.25 PIK48942.1 - 2.2e-46 158.4 0.0 2.9e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48942.1 - 2.2e-38 132.0 0.0 2.7e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK48942.1 - 0.0065 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK48942.1 - 0.061 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 PIK48942.1 - 0.085 11.6 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Sushi PF00084.20 PIK48943.1 - 5e-06 27.0 1.0 2e-05 25.1 1.0 2.1 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) EphA2_TM PF14575.6 PIK48943.1 - 0.02 15.8 0.0 0.056 14.3 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain LEAP-2 PF07359.11 PIK48943.1 - 0.037 13.9 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) TMEM154 PF15102.6 PIK48943.1 - 0.042 13.8 0.2 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family Myticin-prepro PF10690.9 PIK48943.1 - 0.47 10.7 5.6 6.8 7.0 0.3 2.7 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel Fibrinogen_C PF00147.18 PIK48944.1 - 1.2e-19 71.0 1.4 1.6e-19 70.6 1.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK48944.1 - 0.084 12.7 1.3 0.12 12.2 1.3 1.2 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) Integrase_H2C2 PF17921.1 PIK48945.1 - 1.1e-16 60.7 0.5 2.3e-16 59.6 0.5 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK48945.1 - 2.7e-09 37.3 0.0 1e-08 35.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Fibrinogen_C PF00147.18 PIK48946.1 - 6.1e-31 107.9 1.4 7.4e-31 107.7 1.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK48946.1 - 0.0031 16.8 0.1 0.0031 16.8 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain RVT_1 PF00078.27 PIK48947.1 - 4.3e-14 52.6 0.0 6.8e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK48947.1 - 4.2e-10 39.5 0.0 1e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK48947.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Med31 PF05669.12 PIK48948.1 - 0.0027 17.7 3.3 1.4 9.0 3.3 3.1 1 1 0 1 1 1 1 SOH1 DUF1943 PF09172.11 PIK48948.1 - 0.053 12.8 5.1 0.45 9.7 5.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1943) Pkinase PF00069.25 PIK48949.1 - 3.7e-46 157.6 0.0 4.4e-31 108.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48949.1 - 1.7e-18 66.8 0.0 1.1e-17 64.1 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase MTBP_C PF14920.6 PIK48949.1 - 0.004 16.9 4.0 0.0065 16.2 4.0 1.2 1 0 0 1 1 1 1 MDM2-binding Kdo PF06293.14 PIK48949.1 - 0.0047 16.3 0.2 0.037 13.4 0.2 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK48949.1 - 0.0048 16.9 0.1 0.63 9.9 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Glyco_transf_24 PF18404.1 PIK48950.1 - 9.1e-147 487.6 3.8 1.1e-146 487.3 3.8 1.1 1 0 0 1 1 1 1 Glucosyltransferase 24 Glyco_transf_8 PF01501.20 PIK48950.1 - 3.5e-05 23.5 1.3 7.5e-05 22.4 1.3 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Pkinase PF00069.25 PIK48951.1 - 5.5e-66 222.6 0.0 7.3e-66 222.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK48951.1 - 8.9e-41 139.9 0.0 1.2e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK48951.1 - 1.8e-06 27.5 0.0 2.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK48951.1 - 3.7e-05 23.2 0.1 6.6e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK48951.1 - 0.0003 19.9 0.0 0.00043 19.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain COesterase PF00135.28 PIK48952.1 - 4.7e-25 88.5 0.0 5.6e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK48952.1 - 9.7e-08 31.6 7.4 9.7e-08 31.6 7.4 2.0 3 0 0 3 3 3 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK48953.1 - 9.9e-10 37.9 0.0 1.1e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK48954.1 - 6.7e-59 200.1 0.1 8.1e-59 199.8 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family PRC PF05239.16 PIK48954.1 - 0.082 13.0 0.1 0.91 9.6 0.0 2.1 2 0 0 2 2 2 0 PRC-barrel domain Bcl-2 PF00452.19 PIK48955.1 - 2e-16 60.5 0.2 1.6e-15 57.6 0.1 2.0 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family PfUIS3 PF11567.8 PIK48955.1 - 0.067 13.6 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Abhydrolase_3 PF07859.13 PIK48956.1 - 5e-14 52.7 0.0 6.5e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Glyco_hydro_31 PF01055.26 PIK48957.1 - 1.2e-108 364.1 11.5 3.5e-57 194.6 2.5 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK48957.1 - 1.2e-34 119.0 0.1 2.2e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 PIK48957.1 - 1.5e-12 47.2 1.7 3.1e-12 46.2 1.7 1.5 1 0 0 1 1 1 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 PIK48957.1 - 1.3e-08 35.0 0.3 1.3e-08 35.0 0.3 2.0 2 0 0 2 2 2 1 Galactose mutarotase-like UDPG_MGDP_dh_N PF03721.14 PIK48957.1 - 0.0036 16.9 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Clat_adaptor_s PF01217.20 PIK48958.1 - 6.3e-57 191.5 2.2 7.3e-57 191.3 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-CCCH PF00642.24 PIK48959.1 - 6.3e-10 38.7 17.4 1.8e-07 30.9 3.9 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK48959.1 - 1.3e-05 25.0 15.6 0.014 15.4 3.7 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 PIK48959.1 - 0.0013 19.4 0.3 0.0013 19.4 0.3 5.2 3 2 1 5 5 5 1 Torus domain zf-CCCH_4 PF18044.1 PIK48959.1 - 0.0065 16.2 9.9 0.099 12.5 2.2 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger RRM_1 PF00076.22 PIK48959.1 - 0.0079 16.0 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ArdA PF07275.11 PIK48959.1 - 0.12 13.0 0.2 0.12 13.0 0.2 1.7 2 0 0 2 2 2 0 Antirestriction protein (ArdA) zf-CCCH_2 PF14608.6 PIK48959.1 - 5.4 7.7 14.2 2.7 8.6 4.4 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ank_4 PF13637.6 PIK48960.1 - 1.1e-34 118.4 1.8 2.5e-10 40.7 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK48960.1 - 7.6e-28 96.9 1.5 2.2e-18 66.6 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK48960.1 - 1.9e-26 91.3 2.1 2.3e-10 40.4 0.4 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 PIK48960.1 - 2.8e-22 78.5 2.1 2.4e-09 37.3 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK48960.1 - 5.1e-22 75.6 0.2 8.7e-08 31.9 0.2 4.6 4 0 0 4 4 4 4 Ankyrin repeat AnkUBD PF18418.1 PIK48960.1 - 0.1 12.7 0.0 0.38 10.9 0.0 1.9 2 0 0 2 2 2 0 Ankyrin ubiquitin-binding domain AA_permease_2 PF13520.6 PIK48962.1 - 6.9e-14 51.5 13.1 8e-14 51.3 13.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK48962.1 - 0.00036 19.3 13.5 0.00044 19.0 13.5 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4013 PF13197.6 PIK48962.1 - 0.014 15.2 9.0 0.019 14.8 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) Pkinase_Tyr PF07714.17 PIK48963.1 - 1.7e-22 79.9 0.1 8.7e-22 77.6 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48963.1 - 1.3e-13 50.9 0.2 1.8e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain CPSase_L_D2 PF02786.17 PIK48964.1 - 1.6e-82 276.1 0.0 2.5e-82 275.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 PIK48964.1 - 3.6e-45 153.0 0.0 1.1e-44 151.4 0.0 1.9 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 PIK48964.1 - 7.3e-38 129.0 0.0 2.5e-37 127.3 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 PIK48964.1 - 8.3e-17 60.8 2.4 2.7e-16 59.2 2.4 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme PCC_BT PF18140.1 PIK48964.1 - 2.3e-12 47.4 0.0 6.2e-12 46.0 0.0 1.8 1 1 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain ATP-grasp PF02222.22 PIK48964.1 - 1.1e-08 34.8 0.0 2.7e-08 33.6 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 PIK48964.1 - 5.9e-07 29.2 0.0 1.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 PIK48964.1 - 1.7e-05 24.5 1.8 0.13 12.1 0.5 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like RimK PF08443.11 PIK48964.1 - 2e-05 24.3 0.0 9.8e-05 22.0 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain RnfC_N PF13375.6 PIK48964.1 - 0.0035 17.3 1.2 0.016 15.1 1.1 2.2 2 1 0 2 2 2 1 RnfC Barrel sandwich hybrid domain ATP-grasp_5 PF13549.6 PIK48964.1 - 0.0083 15.6 0.0 0.022 14.2 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 PIK48964.1 - 0.031 15.0 0.1 0.39 11.4 0.0 2.5 2 0 0 2 2 2 0 HlyD family secretion protein Epimerase PF01370.21 PIK48965.1 - 1.3e-24 87.0 0.0 1.9e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK48965.1 - 2.7e-24 85.7 0.0 3.4e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK48965.1 - 2.4e-15 56.9 0.0 3.6e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 PIK48965.1 - 2.6e-13 50.1 0.0 3.8e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK48965.1 - 1.2e-12 47.6 0.0 3.2e-12 46.2 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 PIK48965.1 - 2e-08 34.1 0.0 3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 PIK48965.1 - 1.6e-05 24.2 0.0 2.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK48965.1 - 9.4e-05 22.4 0.0 0.00026 21.0 0.0 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 PIK48965.1 - 0.0011 18.4 0.0 0.0037 16.7 0.0 1.8 1 1 1 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK48965.1 - 0.019 14.1 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain 3Beta_HSD PF01073.19 PIK48966.1 - 1.5e-24 86.5 0.0 1.9e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK48966.1 - 7e-23 81.3 0.0 9.3e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK48966.1 - 3.7e-15 56.3 0.0 6.2e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 PIK48966.1 - 3.8e-12 46.2 0.0 5.5e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK48966.1 - 3.9e-10 39.3 0.0 1.2e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 PIK48966.1 - 6.2e-08 32.5 0.0 1.1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 PIK48966.1 - 0.00033 19.9 0.0 0.00049 19.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK48966.1 - 0.0047 16.9 0.0 0.025 14.5 0.0 1.9 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 PIK48966.1 - 0.069 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK48966.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.21 PIK48967.1 - 0.0084 15.6 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK48968.1 - 3.4e-13 49.2 0.0 4.7e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK48968.1 - 1.2e-12 48.1 0.0 1.5e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 PIK48968.1 - 1.4e-12 47.6 0.0 2.1e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK48968.1 - 8.7e-08 31.9 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK48968.1 - 7.7e-07 28.5 0.0 4.4e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 PIK48968.1 - 4.3e-05 23.2 0.0 6.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 PIK48968.1 - 0.0043 17.0 0.0 0.015 15.2 0.0 1.7 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK48968.1 - 0.043 12.9 0.1 0.073 12.2 0.1 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein PK_C PF02887.16 PIK48969.1 - 0.074 13.3 0.0 0.096 12.9 0.0 1.2 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain DAP3 PF10236.9 PIK48972.1 - 5.7e-64 216.2 0.2 7.3e-64 215.9 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 ATPase_2 PF01637.18 PIK48972.1 - 0.00033 20.7 0.0 0.00058 19.8 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea MobB PF03205.14 PIK48972.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 PIK48972.1 - 0.089 12.4 0.2 1.6 8.3 0.0 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 PIK48972.1 - 0.13 11.6 0.0 0.82 9.0 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF3391 PF11871.8 PIK48972.1 - 0.2 12.2 0.2 11 6.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) 4F5 PF04419.14 PIK48973.1 - 1.6e-05 25.6 11.7 1.6e-05 25.6 11.7 2.3 2 0 0 2 2 2 1 4F5 protein family 2OG-FeII_Oxy_5 PF13759.6 PIK48973.1 - 0.21 12.0 1.8 0.37 11.2 1.8 1.5 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase SMN PF06003.12 PIK48974.1 - 9.1e-56 189.0 4.8 1.2e-55 188.7 4.8 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 PIK48974.1 - 0.12 12.4 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Tudor domain MFS_1 PF07690.16 PIK48975.1 - 6.5e-10 38.5 17.7 8e-10 38.2 17.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UDPGT PF00201.18 PIK48976.1 - 1.3e-69 235.3 0.0 1.5e-69 235.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK48976.1 - 0.0013 18.8 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Na_Ca_ex PF01699.24 PIK48977.1 - 5.2e-21 75.2 4.9 5.2e-21 75.2 4.9 1.6 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Na_Ca_ex PF01699.24 PIK48978.1 - 2.5e-26 92.4 13.5 2.9e-26 92.2 13.5 1.0 1 0 0 1 1 1 1 Sodium/calcium exchanger protein BIR PF00653.21 PIK48979.1 - 4.8e-42 142.5 1.3 8.7e-20 71.2 0.2 2.2 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK48979.1 - 0.0001 22.3 0.2 0.034 14.2 0.0 2.4 2 1 0 2 2 2 2 C3HC zinc finger-like zf-C2H2_12 PF18658.1 PIK48979.1 - 0.014 14.9 0.2 4.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger C2H2-type MIF4G_like_2 PF09090.11 PIK48980.1 - 1.5e-75 254.2 6.6 1.5e-75 254.2 6.6 2.1 3 0 0 3 3 3 1 MIF4G like MIF4G_like PF09088.11 PIK48980.1 - 6.6e-37 127.1 1.9 1.5e-36 125.9 1.1 2.1 2 1 0 2 2 2 1 MIF4G like MIF4G PF02854.19 PIK48980.1 - 5.3e-23 81.8 0.6 1.6e-22 80.2 0.0 2.1 2 0 0 2 2 2 1 MIF4G domain CNOT11 PF10155.9 PIK48980.1 - 0.081 13.1 1.9 11 6.2 0.1 3.1 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 TMF_TATA_bd PF12325.8 PIK48980.1 - 2.3 8.5 10.8 1.3 9.3 3.1 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ETC_C1_NDUFA4 PF04800.12 PIK48981.1 - 4e-37 126.3 2.8 5.4e-37 125.9 2.8 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Asp PF00026.23 PIK48983.1 - 5.7e-76 255.9 3.7 6.7e-76 255.7 3.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 PIK48983.1 - 2.8e-05 24.4 0.3 8.2e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal zf-H2C2_2 PF13465.6 PIK48984.1 - 2.4e-138 445.0 150.2 1.2e-10 41.3 1.0 18.1 18 0 0 18 18 18 18 Zinc-finger double domain zf-C2H2 PF00096.26 PIK48984.1 - 3.7e-70 228.6 152.8 4.5e-06 26.8 1.9 17.2 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK48984.1 - 1.2e-67 218.7 145.0 2.3e-05 24.8 1.8 17.6 18 0 0 18 18 17 17 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK48984.1 - 5.9e-42 140.9 145.0 8.7e-07 28.8 1.9 17.5 17 0 0 17 17 17 13 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK48984.1 - 2.6e-41 139.1 125.0 0.00016 21.9 2.3 17.2 17 0 0 17 17 17 14 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK48984.1 - 6.3e-24 83.6 109.0 0.11 12.4 1.0 17.1 14 2 3 17 17 17 14 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_5 PF13909.6 PIK48984.1 - 1.9e-14 53.1 170.6 0.0023 17.7 0.9 20.3 18 3 0 18 18 18 12 C2H2-type zinc-finger domain C1_1 PF00130.22 PIK48984.1 - 1.4e-12 47.3 65.6 0.31 11.0 2.0 13.5 2 2 14 16 16 16 11 Phorbol esters/diacylglycerol binding domain (C1 domain) Siva PF05458.12 PIK48984.1 - 1.4e-11 44.3 37.4 0.19 11.4 0.2 7.9 1 1 7 8 8 8 7 Cd27 binding protein (Siva) zf_C2H2_6 PF18450.1 PIK48984.1 - 6.4e-09 35.4 90.7 0.12 12.1 1.4 16.1 17 0 0 17 17 17 5 Zinc Finger domain zf-C2HE PF16278.5 PIK48984.1 - 1.5e-08 34.9 110.4 0.6 10.6 1.4 16.7 1 1 15 16 16 16 8 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK48984.1 - 0.00068 19.6 110.9 0.93 9.6 0.9 16.8 3 3 14 17 17 17 6 BED zinc finger zf-Di19 PF05605.12 PIK48984.1 - 0.0026 18.0 101.4 1.1 9.5 2.7 11.4 2 1 14 16 16 16 9 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 PIK48984.1 - 0.0032 17.6 103.5 4.1 7.7 2.5 16.8 13 3 4 17 17 17 2 AN1-like Zinc finger CBX7_C PF17218.3 PIK48984.1 - 0.017 14.8 0.0 5.2e+02 0.5 0.0 7.2 11 0 0 11 11 11 0 CBX family C-terminal motif DUF365 PF04033.12 PIK48984.1 - 0.033 14.5 13.8 25 5.2 0.0 7.4 1 1 4 6 6 6 0 Domain of unknown function (DUF365) zinc_ribbon_15 PF17032.5 PIK48984.1 - 0.18 12.6 90.9 1.7 9.4 4.6 9.5 1 1 15 16 16 16 0 zinc-ribbon family zf-C2H2_11 PF16622.5 PIK48984.1 - 0.37 10.6 0.1 0.37 10.6 0.1 13.3 16 0 0 16 16 15 0 zinc-finger C2H2-type tRNA-synt_His PF13393.6 PIK48984.1 - 0.42 9.8 23.4 2.1 7.5 0.1 7.4 3 3 7 10 10 10 0 Histidyl-tRNA synthetase GAGA PF09237.11 PIK48984.1 - 0.88 9.4 40.6 0.98 9.3 0.6 8.8 4 3 5 10 10 10 0 GAGA factor DUF3268 PF11672.8 PIK48984.1 - 1.1 9.7 81.0 0.64 10.4 3.4 8.8 3 1 3 10 10 10 0 zinc-finger-containing domain Adaptin_binding PF10199.9 PIK48984.1 - 1.7 9.3 5.0 3.5e+02 1.8 5.2 3.8 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Zf_RING PF16744.5 PIK48984.1 - 6.1 7.0 77.8 4.4 7.5 0.1 15.1 3 3 12 16 16 16 0 KIAA1045 RING finger DUF1736 PF08409.11 PIK48985.1 - 1.2e-25 89.2 1.3 3.5e-25 87.8 1.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) PMT_2 PF13231.6 PIK48985.1 - 0.12 12.5 11.5 0.02 15.1 7.5 1.8 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase BRI3BP PF14965.6 PIK48985.1 - 0.21 11.1 5.1 7.4 6.1 0.1 2.5 2 0 0 2 2 2 0 Negative regulator of p53/TP53 Tetraspanin PF00335.20 PIK48986.1 - 2.2e-38 132.3 9.0 2.6e-38 132.0 9.0 1.1 1 0 0 1 1 1 1 Tetraspanin family YfhO PF09586.10 PIK48986.1 - 0.16 10.2 2.1 0.17 10.1 2.1 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Tetraspanin PF00335.20 PIK48987.1 - 5e-43 147.4 14.0 5.6e-43 147.3 14.0 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 PIK48987.1 - 0.00015 21.5 2.3 0.00015 21.5 2.3 2.0 2 0 0 2 2 2 1 SUR7/PalI family DUF4218 PF13960.6 PIK48988.1 - 0.042 13.5 1.9 0.077 12.6 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4218) C2-set_2 PF08205.12 PIK48989.1 - 0.00015 21.8 0.2 0.00015 21.8 0.2 2.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK48990.1 - 1.3e-08 35.0 0.3 9.4e-06 25.8 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK48990.1 - 3.2e-07 30.8 0.1 0.00061 20.3 0.0 3.6 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK48990.1 - 0.00013 22.1 0.1 0.55 10.4 0.0 3.3 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK48990.1 - 0.00033 20.9 0.5 0.35 11.2 0.1 3.8 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK48990.1 - 0.0011 19.0 0.1 0.031 14.3 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin I-set domain mono-CXXC PF15626.6 PIK48991.1 - 0.0094 16.3 18.6 3.7 8.0 2.9 6.0 1 1 5 6 6 6 2 single CXXC unit L71 PF02448.15 PIK48991.1 - 0.015 15.7 0.4 41 4.7 0.0 3.2 2 1 0 3 3 3 0 L71 family Hydrophobin_2 PF06766.11 PIK48991.1 - 0.025 14.5 8.0 59 3.7 0.1 5.5 1 1 6 7 7 7 0 Fungal hydrophobin Keratin_B2 PF01500.17 PIK48991.1 - 0.32 11.0 6.6 19 5.2 6.6 2.3 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein TMEM247 PF15444.6 PIK48991.1 - 7.3 6.6 6.0 19 5.2 1.1 2.3 1 1 1 2 2 2 0 Transmembrane protein 247 Ig_3 PF13927.6 PIK48992.1 - 4.1e-10 40.1 6.5 3.2e-08 34.0 0.1 3.9 3 1 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK48992.1 - 2e-08 34.4 0.0 7.2e-08 32.6 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK48992.1 - 1.1e-07 31.8 0.1 4.6e-07 29.8 0.1 2.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK48992.1 - 1.4e-07 31.6 0.8 1.9e-06 27.9 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK48992.1 - 0.00013 22.2 8.6 0.056 13.8 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK48992.1 - 0.0037 17.3 2.5 0.0064 16.5 0.2 2.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK48992.1 - 0.5 10.8 7.9 0.55 10.7 0.5 4.1 4 1 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DED PF01335.21 PIK48992.1 - 3.1 8.2 4.7 11 6.4 0.2 3.1 3 0 0 3 3 3 0 Death effector domain Death PF00531.22 PIK48994.1 - 0.0066 16.6 0.2 0.023 14.9 0.0 1.9 2 0 0 2 2 2 1 Death domain CxxCxxCC PF03692.15 PIK48994.1 - 0.11 13.2 0.1 0.18 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative zinc- or iron-chelating domain GalP_UDP_tr_C PF02744.17 PIK48994.1 - 0.15 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain SSF PF00474.17 PIK48995.1 - 9.5e-37 126.8 14.6 1.2e-36 126.5 14.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family OppC_N PF12911.7 PIK48995.1 - 4.1 7.5 5.2 11 6.1 0.6 3.0 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Pox_Ag35 PF03286.14 PIK48996.1 - 0.0015 18.4 8.1 0.0015 18.4 8.1 2.2 3 0 0 3 3 2 1 Pox virus Ag35 surface protein SPRY PF00622.28 PIK48996.1 - 0.004 17.3 2.1 0.013 15.6 1.0 2.2 1 1 1 2 2 2 1 SPRY domain Serine_protease PF18405.1 PIK48996.1 - 0.091 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Zip PF02535.22 PIK48996.1 - 0.31 10.2 0.9 0.63 9.2 0.9 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Nop14 PF04147.12 PIK48996.1 - 0.59 8.3 15.3 0.95 7.6 15.3 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2052 PF09747.9 PIK48996.1 - 0.65 10.1 14.8 1.8 8.7 14.8 1.7 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TFIIA PF03153.13 PIK48996.1 - 1.9 8.4 13.1 2.9 7.8 13.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Paf1 PF03985.13 PIK48996.1 - 2.8 6.8 21.9 4.7 6.1 21.9 1.3 1 0 0 1 1 1 0 Paf1 DUF4050 PF13259.6 PIK48996.1 - 4.1 7.7 12.4 2 8.7 3.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) RR_TM4-6 PF06459.12 PIK48996.1 - 6.2 6.6 14.3 0.94 9.3 9.8 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TLP-20 PF06088.11 PIK48996.1 - 7.4 6.4 7.3 17 5.3 3.4 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Presenilin PF01080.17 PIK48996.1 - 9.4 4.9 10.1 0.26 10.0 2.8 1.9 2 0 0 2 2 2 0 Presenilin Ig_3 PF13927.6 PIK48997.1 - 1.9e-09 38.0 2.9 5.6e-07 30.1 0.0 3.9 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK48997.1 - 2.9e-08 33.9 0.0 1.1e-07 31.9 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK48997.1 - 4.8e-07 29.7 0.1 9.3e-06 25.6 0.1 3.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK48997.1 - 1.8e-06 28.0 5.4 3.6e-05 23.9 0.0 3.7 3 0 0 3 3 3 1 Immunoglobulin domain Death PF00531.22 PIK48997.1 - 4.6e-06 26.7 1.5 0.06 13.5 0.0 3.6 3 0 0 3 3 3 2 Death domain C2-set_2 PF08205.12 PIK48997.1 - 3e-05 24.0 0.4 0.00013 21.9 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK48997.1 - 6e-05 23.3 2.9 0.1 13.0 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain TelA PF05816.11 PIK48997.1 - 0.014 14.5 0.9 0.014 14.5 0.9 2.2 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) CxxCxxCC PF03692.15 PIK48997.1 - 0.044 14.5 0.5 4.7 8.0 0.1 3.7 4 0 0 4 4 4 0 Putative zinc- or iron-chelating domain Ig_5 PF16681.5 PIK48997.1 - 0.19 12.1 8.6 0.18 12.2 0.3 4.1 4 1 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pkinase_Tyr PF07714.17 PIK48998.1 - 2.5e-18 66.3 0.1 4.1e-18 65.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48998.1 - 1.7e-12 47.3 0.0 4.2e-12 46.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK48998.1 - 5.8e-06 26.4 1.4 2.2e-05 24.6 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK48998.1 - 0.00019 21.4 0.4 0.0072 16.4 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK48998.1 - 0.00027 21.1 2.1 0.012 15.7 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin domain Ig_3 PF13927.6 PIK48998.1 - 0.00088 19.8 5.8 0.033 14.8 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK48998.1 - 0.0045 17.0 2.0 0.0094 16.0 0.2 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ECSCR PF15820.5 PIK48998.1 - 0.024 14.5 0.2 0.11 12.4 0.0 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator FeoB_associated PF12669.7 PIK48998.1 - 0.1 13.0 0.8 0.29 11.6 0.8 1.7 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein TGBp3 PF02495.17 PIK48998.1 - 0.15 11.8 6.9 1.8 8.3 0.1 2.8 3 0 0 3 3 3 0 Triple gene block 3 Pkinase_Tyr PF07714.17 PIK48999.1 - 5e-32 111.2 0.0 8.7e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK48999.1 - 4.1e-21 75.5 0.0 6.7e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK48999.1 - 0.00043 20.8 1.1 0.015 15.9 0.1 2.8 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK48999.1 - 0.0025 17.8 0.2 0.008 16.2 0.2 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK48999.1 - 0.0044 17.3 0.6 0.055 13.8 0.1 2.9 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK48999.1 - 0.035 14.3 0.1 0.1 12.8 0.1 1.8 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK48999.1 - 0.066 13.5 0.9 1 9.7 0.0 2.9 2 1 1 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Vsr PF03852.15 PIK49000.1 - 0.0044 16.8 0.1 0.01 15.7 0.1 1.6 1 0 0 1 1 1 1 DNA mismatch endonuclease Vsr rve PF00665.26 PIK49000.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Rota_NS6 PF04866.12 PIK49000.1 - 0.36 11.1 6.0 0.17 12.1 1.9 2.1 1 1 1 2 2 2 0 Rotavirus non-structural protein 6 rve PF00665.26 PIK49001.1 - 1.7e-06 28.2 0.0 3.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-RVT PF13966.6 PIK49001.1 - 2.2e-06 28.3 1.7 3.5e-06 27.6 0.3 2.0 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase rve_3 PF13683.6 PIK49001.1 - 0.00047 19.9 0.9 0.0011 18.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain MTS PF05175.14 PIK49002.1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain GlutR_dimer PF00745.20 PIK49002.1 - 0.14 12.6 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain RVT_2 PF07727.14 PIK49004.1 - 1.4e-09 37.9 0.0 2.8e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK49005.1 - 1.2e-35 123.4 0.2 1.9e-35 122.7 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK49005.1 - 1.9e-22 79.6 0.0 4.9e-22 78.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 PIK49005.1 - 0.00022 21.0 0.1 0.00042 20.1 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 PIK49005.1 - 0.006 16.3 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Ribosomal_L18A PF01775.17 PIK49007.1 - 8.3e-56 187.3 0.8 9.4e-56 187.1 0.8 1.0 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A PAS PF00989.25 PIK49007.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold Acyl-CoA_dh_1 PF00441.24 PIK49008.1 - 1.8e-07 31.5 0.0 3.5e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1974 PF09317.11 PIK49008.1 - 0.1 12.2 0.1 0.14 11.7 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1974) Acyl-CoA_dh_N PF02771.16 PIK49010.1 - 4.8e-21 75.5 0.0 1.3e-20 74.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 PIK49010.1 - 2.1e-15 57.2 0.3 4.5e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK49010.1 - 1.9e-14 53.6 0.0 1.4e-06 28.4 0.0 2.5 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK49010.1 - 5.5e-06 26.7 0.5 8.8e-05 22.8 0.1 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain 7tm_1 PF00001.21 PIK49012.1 - 4.2e-33 114.8 15.1 4.2e-33 114.8 15.1 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF1445 PF07286.12 PIK49013.1 - 3e-29 101.8 0.0 5.7e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) DUF1445 PF07286.12 PIK49014.1 - 7.9e-07 29.1 0.0 1.4e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) NRD1_2 PF01995.16 PIK49014.1 - 0.061 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 DUF1445 PF07286.12 PIK49015.1 - 5.1e-13 49.2 0.1 8.2e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) UQ_con PF00179.26 PIK49017.1 - 1.2e-41 141.6 0.0 1.6e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK49017.1 - 0.0048 17.2 0.8 0.0089 16.3 0.8 1.6 1 1 0 1 1 1 1 RWD domain DUF3695 PF12494.8 PIK49017.1 - 0.0064 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3695) Prok-E2_B PF14461.6 PIK49017.1 - 0.017 14.8 0.0 0.04 13.6 0.0 1.5 1 1 1 2 2 2 0 Prokaryotic E2 family B UEV PF05743.13 PIK49017.1 - 0.024 14.5 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 UEV domain CUB_2 PF02408.20 PIK49018.1 - 3.5e-06 26.8 17.2 1.4 8.7 0.5 5.4 1 1 6 7 7 7 7 CUB-like domain Band_7_1 PF13421.6 PIK49018.1 - 1.1e-05 25.2 0.2 15 5.2 0.0 4.6 1 1 6 7 7 7 2 SPFH domain-Band 7 family Urease_beta PF00699.20 PIK49018.1 - 0.0022 18.0 29.3 16 5.6 0.5 8.0 1 1 8 9 9 9 3 Urease beta subunit DUF3332 PF11810.8 PIK49018.1 - 0.096 12.3 13.5 0.51 10.0 4.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3332) Methyltransf_FA PF12248.8 PIK49018.1 - 0.11 12.8 10.2 4 7.8 1.4 4.0 1 1 2 3 3 3 0 Farnesoic acid 0-methyl transferase YmzC PF14157.6 PIK49018.1 - 0.32 11.1 24.3 58 3.9 0.8 8.4 1 1 5 6 6 6 0 YmzC-like protein FixG_C PF11614.8 PIK49018.1 - 1.4 9.1 10.3 30 4.8 0.7 3.6 1 1 2 3 3 3 0 IG-like fold at C-terminal of FixG, putative oxidoreductase zf-H2C2 PF09337.10 PIK49018.1 - 6.3 7.1 7.4 2e+02 2.3 0.1 4.8 5 0 0 5 5 5 0 H2C2 zinc finger RVT_1 PF00078.27 PIK49019.1 - 9.6e-27 93.9 0.0 1.2e-26 93.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FYVE PF01363.21 PIK49020.1 - 6.6e-11 42.2 6.1 1.1e-10 41.5 6.1 1.3 1 0 0 1 1 1 1 FYVE zinc finger PBP1_TM PF14812.6 PIK49020.1 - 0.0083 16.5 2.5 0.013 15.9 2.5 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 PIK49020.1 - 0.037 14.1 1.2 0.041 13.9 1.2 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal AIF_C PF14721.6 PIK49020.1 - 0.094 13.1 0.2 0.12 12.7 0.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4611 PF15387.6 PIK49020.1 - 0.13 12.5 6.8 0.17 12.1 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 PIK49020.1 - 0.24 11.0 4.5 0.34 10.6 4.5 1.2 1 0 0 1 1 1 0 FAM176 family FYVE_2 PF02318.16 PIK49020.1 - 0.51 10.6 5.1 0.35 11.1 3.4 1.5 2 0 0 2 2 2 0 FYVE-type zinc finger RRN3 PF05327.11 PIK49020.1 - 1.1 7.8 4.2 1.2 7.6 4.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cwf_Cwc_15 PF04889.12 PIK49020.1 - 2.6 7.7 11.5 3.1 7.5 11.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 PIK49020.1 - 3 6.0 7.3 3.6 5.8 7.3 1.0 1 0 0 1 1 1 0 CDC45-like protein S-antigen PF05756.11 PIK49020.1 - 5.1 7.5 7.3 7.2 7.1 7.3 1.2 1 0 0 1 1 1 0 S-antigen protein CENP-B_dimeris PF09026.10 PIK49020.1 - 8 6.9 14.2 12 6.4 14.2 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RVT_1 PF00078.27 PIK49021.1 - 3.9e-05 23.3 0.0 6.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK49022.1 - 8.4e-38 130.1 0.0 1.1e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4614 PF15391.6 PIK49023.1 - 2.5 8.1 10.1 6.5 6.7 10.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PhageMin_Tail PF10145.9 PIK49024.1 - 0.074 12.9 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Phage-related minor tail protein Retrotrans_gag PF03732.17 PIK49025.1 - 2.3e-05 24.6 0.3 2.3e-05 24.6 0.3 2.8 3 1 1 4 4 4 1 Retrotransposon gag protein Arfaptin PF06456.13 PIK49025.1 - 0.047 13.3 0.7 1.6 8.3 0.3 2.1 1 1 1 2 2 2 0 Arfaptin-like domain FAM70 PF14967.6 PIK49025.1 - 0.18 11.2 0.1 0.3 10.5 0.1 1.5 1 1 0 1 1 1 0 FAM70 protein HWE_HK PF07536.14 PIK49025.1 - 0.27 12.0 1.9 0.91 10.3 0.6 2.1 1 1 1 2 2 2 0 HWE histidine kinase rve PF00665.26 PIK49026.1 - 1.8e-23 83.0 0.0 5.5e-23 81.4 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain SCAN PF02023.17 PIK49026.1 - 3e-13 49.4 0.5 1e-12 47.7 0.1 2.1 2 0 0 2 2 2 1 SCAN domain rve_3 PF13683.6 PIK49026.1 - 1.1e-05 25.1 0.1 4.7e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_3 PF13917.6 PIK49026.1 - 0.0037 17.2 1.1 0.012 15.6 1.1 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK49026.1 - 0.013 15.6 0.5 0.026 14.6 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle ROS_MUCR PF05443.11 PIK49026.1 - 0.082 13.0 0.3 3.6 7.7 0.1 2.8 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein RVT_1 PF00078.27 PIK49027.1 - 1.2e-29 103.5 0.0 1.7e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trypan_PARP PF05887.11 PIK49028.1 - 0.00022 21.2 24.1 0.00022 21.2 24.1 2.7 2 1 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Cadherin PF00028.17 PIK49029.1 - 1.6e-25 89.4 6.1 7.6e-07 29.5 0.1 5.1 5 0 0 5 5 5 4 Cadherin domain Cadherin_2 PF08266.12 PIK49029.1 - 0.00022 21.0 0.0 0.8 9.6 0.0 3.5 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.5 PIK49029.1 - 0.055 13.5 0.8 1.9 8.5 0.0 3.5 3 0 0 3 3 3 0 Cadherin-like Ribosomal_S11 PF00411.19 PIK49029.1 - 0.1 13.0 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S11 SPARC_Ca_bdg PF10591.9 PIK49030.1 - 2.7e-09 37.3 0.0 5.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 PIK49030.1 - 1.9e-06 27.9 4.3 1.9e-06 27.9 4.3 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 PIK49030.1 - 0.00052 20.1 0.4 0.00099 19.2 0.4 1.5 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain Kazal_1 PF00050.21 PIK49030.1 - 0.0029 17.6 4.0 0.0029 17.6 4.0 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain EGF PF00008.27 PIK49030.1 - 0.036 14.4 2.9 0.12 12.7 2.9 1.9 1 0 0 1 1 1 0 EGF-like domain PDEase_I PF00233.19 PIK49031.1 - 4.4e-78 262.3 0.9 6.8e-78 261.7 0.9 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 PIK49033.1 - 1.3e-21 77.6 0.0 1.1e-18 68.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 PIK49033.1 - 1.4e-10 41.6 0.0 1.5e-09 38.2 0.0 2.2 2 0 0 2 2 2 1 GAF domain QWRF PF04484.12 PIK49033.1 - 0.038 13.7 2.2 0.073 12.8 2.2 1.4 1 0 0 1 1 1 0 QWRF family MOSC PF03473.17 PIK49033.1 - 0.085 12.9 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 MOSC domain GAF_3 PF13492.6 PIK49033.1 - 0.089 13.1 0.0 13 6.1 0.0 3.0 2 1 0 2 2 2 0 GAF domain I-set PF07679.16 PIK49034.1 - 2.5e-06 27.4 0.0 5.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK49034.1 - 2.8e-05 24.6 0.3 6.7e-05 23.4 0.3 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_8 PF13855.6 PIK49034.1 - 9.8e-05 22.0 19.6 0.2 11.5 2.6 4.9 4 2 1 5 5 5 3 Leucine rich repeat LRRCT PF01463.24 PIK49034.1 - 0.00056 20.3 0.3 0.0014 19.1 0.3 1.7 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Ig_2 PF13895.6 PIK49034.1 - 0.0053 17.1 0.4 0.024 15.0 0.4 2.1 1 1 1 2 2 2 1 Immunoglobulin domain LRRNT PF01462.18 PIK49034.1 - 0.0086 15.7 2.7 0.0086 15.7 2.7 2.5 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK49034.1 - 0.013 15.9 7.5 12 6.9 0.1 5.4 4 0 0 4 4 4 0 Leucine Rich Repeat Shisa PF13908.6 PIK49034.1 - 0.019 15.2 0.1 0.048 13.9 0.1 1.7 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EVI2A PF05399.11 PIK49034.1 - 0.023 14.3 3.9 0.044 13.4 3.9 1.4 1 1 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) TMIE PF16038.5 PIK49034.1 - 0.033 14.0 0.4 0.077 12.8 0.4 1.5 1 0 0 1 1 1 0 TMIE protein LRR_4 PF12799.7 PIK49034.1 - 0.55 10.7 22.6 1.7 9.1 0.1 4.7 4 2 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK49035.1 - 6.8e-12 45.0 13.9 4.1e-07 29.7 0.3 3.7 2 2 1 3 3 3 3 Leucine rich repeat Ig_3 PF13927.6 PIK49035.1 - 1e-08 35.7 0.0 2.4e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.18 PIK49035.1 - 2.8e-08 33.2 5.0 2.8e-08 33.2 5.0 2.7 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain I-set PF07679.16 PIK49035.1 - 1.2e-07 31.7 0.0 2.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK49035.1 - 1.3e-07 31.7 0.0 3.7e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49035.1 - 2e-07 31.2 0.2 7.7e-07 29.4 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_4 PF12799.7 PIK49035.1 - 3e-06 27.5 11.0 0.15 12.6 0.0 4.5 2 2 3 5 5 5 3 Leucine Rich repeats (2 copies) LRRCT PF01463.24 PIK49035.1 - 0.0042 17.5 0.5 0.013 16.0 0.5 1.9 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 PIK49035.1 - 0.0049 17.2 4.2 16 6.5 0.0 5.9 6 0 0 6 6 6 1 Leucine Rich Repeat UxuA PF03786.13 PIK49035.1 - 0.2 10.4 0.1 0.29 9.9 0.1 1.1 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) Guanylate_cyc PF00211.20 PIK49037.1 - 5.9e-30 104.2 0.0 7.4e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain SRP_TPR_like PF17004.5 PIK49038.1 - 1.1e-23 83.5 6.6 1.4e-20 73.4 0.4 3.2 3 0 0 3 3 3 2 Putative TPR-like repeat SRP72 PF08492.12 PIK49038.1 - 4.6e-16 59.0 7.0 4.6e-16 59.0 7.0 2.7 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_14 PF13428.6 PIK49038.1 - 1.5e-12 47.2 1.9 0.37 11.7 0.0 6.4 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49038.1 - 4.8e-11 41.9 7.8 0.25 11.6 0.0 7.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK49038.1 - 8e-10 38.7 5.6 0.068 13.8 0.0 6.6 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49038.1 - 8.7e-10 39.0 10.5 0.0014 19.1 0.1 6.7 4 3 3 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK49038.1 - 1.6e-09 37.9 4.2 0.00045 20.4 0.4 5.1 4 2 2 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK49038.1 - 2.6e-09 37.2 11.5 0.00062 19.9 0.1 6.3 3 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 PIK49038.1 - 1.9e-07 30.7 10.5 0.034 14.4 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49038.1 - 2e-06 27.3 14.3 0.017 14.9 0.0 7.7 9 1 0 9 9 8 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK49038.1 - 3.6e-05 22.9 1.6 0.00019 20.6 0.4 2.1 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_21 PF09976.9 PIK49038.1 - 0.00024 20.9 2.6 0.0098 15.6 0.3 3.9 2 2 2 4 4 4 2 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 PIK49038.1 - 0.00038 20.1 0.2 2 8.2 0.0 4.4 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.6 PIK49038.1 - 0.003 18.2 1.7 65 4.3 0.0 5.7 4 2 2 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK49038.1 - 0.01 16.2 1.6 8 7.1 0.1 4.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK49038.1 - 0.014 15.5 2.9 3.5 7.8 0.0 5.0 5 1 0 6 6 5 0 Tetratricopeptide repeat BTAD PF03704.17 PIK49038.1 - 0.016 15.7 0.2 0.09 13.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial transcriptional activator domain CgtA PF06306.11 PIK49038.1 - 0.017 14.6 0.2 0.027 13.9 0.2 1.3 1 0 0 1 1 1 0 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) TPR_10 PF13374.6 PIK49038.1 - 0.023 14.5 0.8 38 4.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Prefoldin PF02996.17 PIK49038.1 - 0.029 14.3 5.2 4.7 7.1 0.1 4.7 3 2 2 5 5 5 0 Prefoldin subunit TPR_20 PF14561.6 PIK49038.1 - 0.044 14.1 3.6 5.3 7.4 0.1 3.9 2 1 2 4 4 4 0 Tetratricopeptide repeat rpo30_N PF12410.8 PIK49038.1 - 0.055 13.4 2.3 0.12 12.2 2.3 1.5 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit Hydrophob_seed PF14547.6 PIK49038.1 - 0.062 13.5 1.6 14 5.9 1.0 2.4 2 0 0 2 2 2 0 Hydrophobic seed protein TPR_MalT PF17874.1 PIK49038.1 - 0.096 12.0 0.1 2.1 7.6 0.0 2.6 3 0 0 3 3 3 0 MalT-like TPR region TPR_5 PF12688.7 PIK49038.1 - 0.15 12.3 0.3 19 5.5 0.1 2.8 2 0 0 2 2 2 0 Tetratrico peptide repeat FAM199X PF15814.5 PIK49038.1 - 1.2 8.1 6.1 2.4 7.1 6.1 1.4 1 0 0 1 1 1 0 Protein family FAM199X zf-C4 PF00105.18 PIK49039.1 - 2.7e-32 111.0 13.0 2.7e-32 111.0 13.0 1.4 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) zf-Di19 PF05605.12 PIK49039.1 - 0.12 12.7 3.3 2.2 8.7 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CHCC PF10276.9 PIK49039.1 - 0.33 11.1 4.4 1.3 9.1 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger domain Zn_Tnp_IS1595 PF12760.7 PIK49039.1 - 3.5 7.7 11.3 0.45 10.5 0.7 2.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Hormone_recep PF00104.30 PIK49040.1 - 2.4e-19 69.7 1.4 4.6e-19 68.8 1.4 1.4 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Thioredoxin_16 PF18569.1 PIK49040.1 - 0.041 14.0 0.0 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Pyr_redox_2 PF07992.14 PIK49041.1 - 2.3e-06 27.1 0.0 2.4e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK49041.1 - 7.2e-05 22.2 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK49041.1 - 9.1e-05 21.9 0.0 0.00026 20.4 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 PIK49041.1 - 0.00038 19.7 0.0 0.00054 19.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 PIK49041.1 - 0.0006 20.3 0.0 0.0038 17.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK49041.1 - 0.001 17.9 0.0 0.0016 17.2 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 PIK49041.1 - 0.0041 16.2 0.0 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 PIK49041.1 - 0.0072 15.7 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 PIK49041.1 - 0.0096 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK49041.1 - 0.025 14.8 0.0 0.064 13.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 PIK49041.1 - 0.053 14.0 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 PIK49041.1 - 0.067 12.4 0.0 0.21 10.8 0.0 1.8 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 PIK49041.1 - 0.11 11.8 0.0 0.26 10.6 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 PIK49041.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase RasGEF PF00617.19 PIK49043.1 - 1.2e-50 172.2 0.4 2.4e-50 171.2 0.2 1.6 2 0 0 2 2 2 1 RasGEF domain TPR_12 PF13424.6 PIK49045.1 - 8.9e-48 160.5 37.6 5.6e-14 52.2 0.2 6.5 2 2 6 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49045.1 - 3.1e-33 112.2 29.7 1.7e-06 27.6 0.0 8.6 9 0 0 9 9 9 7 Tetratricopeptide repeat GoLoco PF02188.17 PIK49045.1 - 9e-33 111.3 25.8 3.3e-11 42.4 3.3 4.3 4 0 0 4 4 4 4 GoLoco motif TPR_7 PF13176.6 PIK49045.1 - 3.2e-31 105.1 20.4 0.00012 21.8 0.0 9.2 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49045.1 - 1.8e-19 68.2 20.7 0.0072 16.5 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49045.1 - 2.6e-19 67.7 26.7 0.011 15.8 0.1 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_10 PF13374.6 PIK49045.1 - 8.3e-19 66.8 19.4 0.0055 16.5 0.0 8.8 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.6 PIK49045.1 - 1.5e-08 35.1 12.1 0.19 12.4 0.4 6.7 2 2 5 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.14 PIK49045.1 - 2.4e-07 30.7 3.1 1.6 9.6 0.1 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat Rapsyn_N PF10579.9 PIK49045.1 - 2.7e-07 30.6 0.4 0.7 10.0 0.0 4.7 4 2 1 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.6 PIK49045.1 - 5.8e-07 29.8 2.5 11 7.2 0.0 6.8 4 3 3 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK49045.1 - 0.00016 21.2 4.2 0.016 14.6 1.8 2.6 2 1 1 3 3 3 2 MalT-like TPR region ANAPC5 PF12862.7 PIK49045.1 - 0.00022 21.2 1.5 20 5.4 0.4 5.0 3 1 0 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_11 PF13414.6 PIK49045.1 - 0.0055 16.4 19.3 0.056 13.1 1.1 7.2 6 3 2 8 8 8 1 TPR repeat UreE_C PF05194.12 PIK49045.1 - 0.036 14.6 5.8 0.46 11.0 0.1 4.4 4 2 2 6 6 4 0 UreE urease accessory protein, C-terminal domain RPN7 PF10602.9 PIK49045.1 - 0.16 11.7 0.7 15 5.3 0.1 2.7 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_6 PF13174.6 PIK49045.1 - 0.17 12.6 7.0 3.4e+02 2.2 0.0 7.1 8 1 0 8 8 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK49045.1 - 0.22 11.6 7.2 43 4.3 0.0 5.5 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 PIK49045.1 - 3.9 8.1 12.9 11 6.7 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK49045.1 - 4.4 7.6 14.3 4.3 7.6 0.0 4.9 3 2 3 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 RPAP2_Rtr1 PF04181.13 PIK49046.1 - 1.6e-15 57.2 0.1 1.7e-15 57.1 0.1 1.0 1 0 0 1 1 1 1 Rtr1/RPAP2 family zf-H2C2_2 PF13465.6 PIK49047.1 - 4.4e-25 86.9 30.4 3.8e-08 33.4 2.3 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 PIK49047.1 - 2.7e-24 84.2 34.3 6.1e-07 29.5 2.0 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK49047.1 - 2.6e-19 68.3 31.1 2.2e-05 24.9 1.7 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK49047.1 - 5.7e-11 42.1 29.5 0.00097 19.1 2.6 4.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK49047.1 - 8.8e-09 35.4 12.6 0.065 13.6 0.2 4.8 4 1 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK49047.1 - 2.5e-07 30.6 17.6 0.16 12.0 2.7 4.3 2 1 2 4 4 4 3 BED zinc finger zf-Di19 PF05605.12 PIK49047.1 - 4.4e-07 30.1 14.5 5.8e-05 23.3 4.6 3.3 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.6 PIK49047.1 - 9.4e-06 25.5 5.5 1.4 8.9 0.1 4.3 4 0 0 4 4 4 1 Prokaryotic RING finger family 1 zf-C2H2_2 PF12756.7 PIK49047.1 - 3.5e-05 24.1 18.8 0.083 13.2 0.6 4.1 1 1 3 4 4 4 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 PIK49047.1 - 6.9e-05 22.9 11.5 0.0041 17.2 1.9 3.5 2 1 2 4 4 4 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 PIK49047.1 - 0.00026 20.7 25.1 0.019 14.7 0.5 4.9 5 0 0 5 5 5 2 zinc-finger C2H2-type C1_1 PF00130.22 PIK49047.1 - 0.0003 20.6 13.8 0.093 12.6 3.6 2.7 2 1 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.5 PIK49047.1 - 0.00056 20.6 6.4 0.092 13.5 1.1 2.2 1 1 1 2 2 2 2 zinc-ribbon family HypA PF01155.19 PIK49047.1 - 0.00079 19.4 5.5 0.013 15.5 0.5 2.2 1 1 1 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GAGA PF09237.11 PIK49047.1 - 0.0011 18.8 4.2 1.6 8.6 0.4 3.2 1 1 2 3 3 3 2 GAGA factor zf-C2H2_3rep PF18868.1 PIK49047.1 - 0.0011 19.6 12.8 0.15 12.7 2.2 3.7 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats DZR PF12773.7 PIK49047.1 - 0.0014 18.6 10.8 0.17 11.9 10.8 2.6 1 1 0 1 1 1 1 Double zinc ribbon PyrI_C PF02748.15 PIK49047.1 - 0.0021 17.9 6.0 1.1 9.2 0.0 4.0 4 0 0 4 4 4 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 PIK49047.1 - 0.0026 17.8 12.6 0.04 14.0 0.2 4.0 4 0 0 4 4 4 2 Zinc-finger domain CpXC PF14353.6 PIK49047.1 - 0.003 17.6 9.3 1.6 8.8 0.1 4.0 1 1 3 4 4 4 1 CpXC protein zf-C2H2_9 PF16293.5 PIK49047.1 - 0.0055 16.5 4.2 2.9 7.8 0.1 3.7 2 1 2 4 4 4 1 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 PIK49047.1 - 0.0061 16.4 18.7 0.49 10.4 0.7 4.7 5 0 0 5 5 4 1 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 PIK49047.1 - 0.0063 17.0 7.3 3.2 8.3 0.1 4.4 4 1 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain YhfH PF14149.6 PIK49047.1 - 0.0063 16.5 8.2 5.4 7.1 0.3 4.1 3 1 1 4 4 4 0 YhfH-like protein Cys_rich_CPXG PF14255.6 PIK49047.1 - 0.0065 16.3 3.7 0.19 11.6 0.8 3.4 3 1 0 3 3 3 1 Cysteine-rich CPXCG zf-C2HE PF16278.5 PIK49047.1 - 0.0093 16.4 18.6 1.9 9.0 1.3 4.1 1 1 3 4 4 4 1 C2HE / C2H2 / C2HC zinc-binding finger ADK_lid PF05191.14 PIK49047.1 - 0.0095 15.9 8.7 0.43 10.6 2.6 3.3 3 0 0 3 3 3 1 Adenylate kinase, active site lid FYDLN_acid PF09538.10 PIK49047.1 - 0.012 16.3 5.0 1.2 9.9 0.5 3.7 1 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-AN1 PF01428.16 PIK49047.1 - 0.021 15.0 16.2 1.6 9.0 0.5 4.4 3 1 1 4 4 4 0 AN1-like Zinc finger zf-LYAR PF08790.11 PIK49047.1 - 0.025 14.5 14.3 1.7 8.7 0.9 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger DUF2256 PF10013.9 PIK49047.1 - 0.054 13.6 11.3 9.6 6.4 0.1 4.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) HNH PF01844.23 PIK49047.1 - 0.073 13.3 12.4 3.3 7.9 0.5 4.3 4 0 0 4 4 4 0 HNH endonuclease HNH_5 PF14279.6 PIK49047.1 - 0.074 12.9 9.5 5.6 6.9 0.5 4.4 4 1 0 4 4 4 0 HNH endonuclease zf-met PF12874.7 PIK49047.1 - 0.076 13.4 26.8 0.91 10.0 0.0 4.6 5 0 0 5 5 4 0 Zinc-finger of C2H2 type FYVE PF01363.21 PIK49047.1 - 0.077 13.1 16.7 1.3 9.2 4.2 3.1 1 1 1 2 2 2 0 FYVE zinc finger XPA_N PF01286.18 PIK49047.1 - 0.082 13.0 10.6 4.9 7.3 0.5 4.0 4 0 0 4 4 4 0 XPA protein N-terminal zf_UBZ PF18439.1 PIK49047.1 - 0.091 12.4 16.3 0.35 10.5 0.1 4.5 4 1 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf_ZIC PF18366.1 PIK49047.1 - 0.11 12.6 9.6 4.9 7.3 0.4 3.8 2 1 2 4 4 4 0 Zic proteins zinc finger domain Elf1 PF05129.13 PIK49047.1 - 0.18 11.9 10.6 1.2 9.2 2.7 3.1 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like HalOD2 PF18547.1 PIK49047.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.9 4 0 0 4 4 2 0 Halobacterial output domain 2 zf-ribbon_3 PF13248.6 PIK49047.1 - 0.23 10.9 6.1 0.51 9.8 0.1 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 PIK49047.1 - 0.25 11.3 10.2 4 7.5 2.5 3.2 1 1 2 3 3 3 0 zinc-ribbons DUF4379 PF14311.6 PIK49047.1 - 0.27 11.6 6.9 2.2 8.7 0.6 3.2 2 1 0 2 2 2 0 Probable Zinc-ribbon domain TF_Zn_Ribbon PF08271.12 PIK49047.1 - 0.27 10.8 5.1 5.1 6.7 0.1 3.5 4 0 0 4 4 4 0 TFIIB zinc-binding zf-H2C2_5 PF13909.6 PIK49047.1 - 0.52 10.1 0.1 0.47 10.2 0.5 6.1 6 2 0 6 6 5 0 C2H2-type zinc-finger domain DUF3268 PF11672.8 PIK49047.1 - 0.54 10.6 7.7 0.96 9.8 1.8 2.6 1 1 3 4 4 4 0 zinc-finger-containing domain zf_C2H2_ZHX PF18387.1 PIK49047.1 - 0.54 9.9 0.1 0.54 9.9 0.1 3.6 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_9 PF14369.6 PIK49047.1 - 0.64 10.3 0.0 0.64 10.3 0.0 3.3 4 0 0 4 4 3 0 zinc-ribbon FdhE PF04216.12 PIK49047.1 - 0.9 9.4 4.5 0.47 10.3 0.3 2.1 1 1 1 2 2 2 0 Protein involved in formate dehydrogenase formation Zn_ribbon_SprT PF17283.2 PIK49047.1 - 1.4 8.9 16.3 0.13 12.2 3.8 3.1 2 1 2 4 4 4 0 SprT-like zinc ribbon domain DUF2072 PF09845.9 PIK49047.1 - 1.5 9.0 12.5 0.21 11.9 2.2 3.0 2 2 0 2 2 2 0 Zn-ribbon containing protein Actin_micro PF17003.5 PIK49047.1 - 1.6 7.9 11.2 1.4e+03 -1.9 11.2 3.2 1 1 0 1 1 1 0 Putative actin-like family LIM PF00412.22 PIK49047.1 - 1.9 8.8 14.0 4.4 7.6 3.4 3.5 1 1 2 3 3 3 0 LIM domain ARS2 PF04959.13 PIK49047.1 - 2.2 8.6 8.6 11 6.4 0.2 2.7 1 1 2 3 3 3 0 Arsenite-resistance protein 2 TFIIS_C PF01096.18 PIK49047.1 - 2.4 8.1 12.2 7.5 6.5 0.3 3.7 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) zf-trcl PF13451.6 PIK49047.1 - 2.7 8.0 13.0 1.8 8.5 0.4 3.7 3 1 0 3 3 3 0 Probable zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 PIK49047.1 - 6.8 6.8 16.0 5.4 7.1 0.1 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 PIK49047.1 - 7 6.7 12.9 8.5 6.4 0.5 3.4 1 1 1 3 3 3 0 Putative transposase DNA-binding domain DUF983 PF06170.12 PIK49047.1 - 9.1 6.8 8.1 98 3.5 0.1 3.7 4 0 0 4 4 3 0 Protein of unknown function (DUF983) zf-C2H2_4 PF13894.6 PIK49048.1 - 0.00098 19.8 5.1 0.06 14.2 1.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK49048.1 - 0.0035 17.7 5.3 1.5 9.4 1.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-LYAR PF08790.11 PIK49048.1 - 0.058 13.3 5.4 0.11 12.4 0.8 2.3 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 PIK49048.1 - 0.091 12.9 2.7 3.6 7.8 0.7 2.4 2 0 0 2 2 2 0 Zinc ribbon domain DUF629 PF04780.12 PIK49048.1 - 0.27 9.7 1.0 0.37 9.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf_C2H2_ZHX PF18387.1 PIK49048.1 - 0.99 9.1 3.3 2.4 7.9 0.4 2.2 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 PIK49048.1 - 1 9.5 4.0 7.5 6.7 1.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger BNR_2 PF13088.6 PIK49049.1 - 7e-06 25.5 0.0 8.4e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK49049.1 - 1.5 9.1 6.5 10 6.6 1.0 3.0 3 0 0 3 3 3 0 BNR/Asp-box repeat Thyroglobulin_1 PF00086.18 PIK49050.1 - 4.1e-13 48.8 1.1 5.1e-13 48.5 0.3 1.7 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Lipocalin_2 PF08212.12 PIK49050.1 - 0.16 11.9 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipocalin-like domain RasGEF_N PF00618.20 PIK49052.1 - 4.8e-12 46.0 1.3 6.6e-12 45.6 1.3 1.3 1 0 0 1 1 1 1 RasGEF N-terminal motif Imm6 PF14434.6 PIK49052.1 - 0.078 12.9 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Immunity protein Imm6 RasGEF PF00617.19 PIK49053.1 - 4e-51 173.7 1.1 6.3e-51 173.1 1.1 1.3 1 0 0 1 1 1 1 RasGEF domain Pkinase_Tyr PF07714.17 PIK49054.1 - 6.7e-29 101.0 0.0 1.1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49054.1 - 1.4e-26 93.4 0.0 2.4e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Vip3A_N PF12495.8 PIK49054.1 - 0.051 13.5 2.0 0.12 12.3 2.0 1.6 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Pkinase PF00069.25 PIK49055.1 - 5.5e-30 104.6 0.1 1.4e-29 103.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49055.1 - 1.1e-29 103.5 0.0 1.7e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Occludin_ELL PF07303.13 PIK49055.1 - 0.0088 16.8 8.4 3.1 8.6 0.8 3.8 3 0 0 3 3 3 2 Occludin homology domain Rab5-bind PF09311.11 PIK49055.1 - 0.024 14.0 0.3 0.024 14.0 0.3 2.7 3 0 0 3 3 3 0 Rabaptin-like protein DUF4665 PF15679.5 PIK49055.1 - 0.11 13.1 7.4 0.078 13.6 2.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4665) DUF1048 PF06304.11 PIK49055.1 - 0.14 12.6 1.9 2 8.9 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1048) NifT PF06988.11 PIK49055.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 NifT/FixU protein Lzipper-MIP1 PF14389.6 PIK49055.1 - 0.16 12.3 5.7 0.31 11.4 0.2 3.1 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 PMC2NT PF08066.12 PIK49055.1 - 0.21 12.3 2.8 2.3 9.0 0.1 3.1 2 1 1 3 3 3 0 PMC2NT (NUC016) domain Bul1_C PF04426.12 PIK49055.1 - 0.26 10.6 7.7 0.034 13.6 1.7 2.1 1 1 1 2 2 2 0 Bul1 C terminus IMD PF08397.11 PIK49055.1 - 0.69 9.2 6.0 0.095 12.1 0.6 2.2 3 0 0 3 3 3 0 IRSp53/MIM homology domain DivIC PF04977.15 PIK49055.1 - 1.1 9.1 5.1 12 5.8 1.2 2.7 2 0 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.12 PIK49055.1 - 1.8 8.6 4.9 0.98 9.5 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) PhaP_Bmeg PF09602.10 PIK49055.1 - 3.9 7.4 9.0 0.8 9.6 0.9 2.8 2 1 0 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) TMPIT PF07851.13 PIK49055.1 - 5.2 6.2 6.8 0.52 9.5 0.7 2.2 2 1 1 3 3 3 0 TMPIT-like protein F5_F8_type_C PF00754.25 PIK49056.1 - 7.5e-17 61.6 0.0 1e-16 61.2 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain Pkinase_Tyr PF07714.17 PIK49057.1 - 4.3e-83 278.6 0.0 5.6e-83 278.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49057.1 - 1.2e-37 129.7 0.0 3e-36 125.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain DUF2613 PF11021.8 PIK49057.1 - 0.016 15.3 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Haspin_kinase PF12330.8 PIK49057.1 - 0.089 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 PIK49057.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF4690 PF15756.5 PIK49057.1 - 0.18 12.4 0.3 0.51 11.0 0.0 1.8 2 0 0 2 2 2 0 Small Novel Rich in Cartilage LapA_dom PF06305.11 PIK49057.1 - 0.27 11.1 0.8 0.46 10.3 0.8 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Acetyltransf_16 PF05301.11 PIK49058.1 - 4.2e-70 235.0 0.4 5.7e-70 234.6 0.4 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 PIK49058.1 - 4.9e-05 23.7 0.0 0.00014 22.2 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 PIK49058.1 - 0.0027 17.6 0.0 0.0057 16.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK49058.1 - 0.0043 17.3 0.0 0.0083 16.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SURF2 PF05477.11 PIK49059.1 - 8.5e-41 140.2 11.4 1.1e-40 139.8 11.4 1.1 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) AAA_11 PF13086.6 PIK49061.1 - 2.2e-24 86.7 0.2 1.9e-14 54.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 PIK49061.1 - 8.6e-23 81.0 0.0 1.7e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK49061.1 - 9.8e-08 31.9 0.1 9.8e-07 28.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 PIK49061.1 - 4.3e-06 26.5 0.0 0.00031 20.4 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 PIK49061.1 - 1.8e-05 25.1 0.3 0.00011 22.6 0.1 2.3 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 PIK49061.1 - 0.0025 17.6 0.4 1.8 8.2 0.0 3.1 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 PIK49061.1 - 0.0047 16.4 0.2 0.024 14.1 0.2 2.2 1 1 0 1 1 1 1 PhoH-like protein ResIII PF04851.15 PIK49061.1 - 0.012 15.6 0.0 0.05 13.6 0.0 2.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 PIK49061.1 - 0.028 14.3 0.0 0.5 10.2 0.0 2.5 2 1 0 2 2 2 0 Helicase AAA_22 PF13401.6 PIK49061.1 - 0.053 13.8 0.0 0.24 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain ECH_1 PF00378.20 PIK49062.1 - 4.2e-41 140.9 0.1 9.3e-41 139.8 0.1 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK49062.1 - 9.8e-23 81.2 0.1 1.2e-22 80.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 PIK49062.1 - 0.0034 16.4 0.2 0.0086 15.1 0.1 1.5 1 1 0 1 1 1 1 Serine dehydrogenase proteinase WD40 PF00400.32 PIK49063.1 - 2.1e-07 31.5 0.1 8.4 7.5 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat Borrelia_P83 PF05262.11 PIK49063.1 - 0.029 12.9 5.5 0.053 12.0 5.5 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein HELP PF03451.14 PIK49063.1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 HELP motif MIIP PF15734.5 PIK49063.1 - 1.9 7.9 6.1 3 7.3 6.1 1.2 1 0 0 1 1 1 0 Migration and invasion-inhibitory Sh_2 PF17512.2 PIK49064.1 - 0.044 13.6 0.1 0.094 12.5 0.1 1.5 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Inv-AAD PF18785.1 PIK49064.1 - 0.084 12.7 0.1 13 5.7 0.0 3.5 4 0 0 4 4 4 0 Invertebrate-AID/APOBEC-deaminase DUF3800 PF12686.7 PIK49064.1 - 1.6 9.4 12.4 1.8e+04 -5.2 12.4 4.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF2433 PF10360.9 PIK49064.1 - 6.9 6.8 8.0 4.8 7.3 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2433) Esterase_phd PF10503.9 PIK49065.1 - 4.3e-05 23.1 0.8 0.00011 21.8 0.0 1.9 2 1 0 2 2 2 1 Esterase PHB depolymerase ABC_membrane PF00664.23 PIK49066.1 - 7.5e-14 52.0 6.8 1e-13 51.6 6.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Bac_GDH PF05088.12 PIK49066.1 - 0.087 10.3 0.0 0.14 9.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DUF3561 PF12084.8 PIK49066.1 - 1.2 9.2 6.3 1.2 9.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) Ig_2 PF13895.6 PIK49067.1 - 0.0045 17.3 1.1 0.56 10.6 0.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain DUF3821 PF12863.7 PIK49067.1 - 0.034 14.0 0.2 0.062 13.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3821) Choline_kinase PF01633.20 PIK49068.1 - 8.4e-61 205.2 0.0 1.2e-60 204.7 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 PIK49068.1 - 4.9e-12 46.3 0.0 7.1e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 PIK49068.1 - 5.5e-05 22.6 1.4 5.7e-05 22.6 0.4 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Sulfotransfer_1 PF00685.27 PIK49069.1 - 1.7e-09 37.6 0.3 3.1e-09 36.7 0.2 1.5 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK49069.1 - 0.029 14.8 0.2 0.065 13.6 0.2 1.5 1 0 0 1 1 1 0 Sulfotransferase family TSP_1 PF00090.19 PIK49070.1 - 1.9e-17 63.2 55.7 4.9e-06 26.7 2.5 6.3 5 1 1 6 6 6 5 Thrombospondin type 1 domain DUF5027 PF16430.5 PIK49070.1 - 0.0024 17.7 4.9 0.27 11.0 0.1 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF5027) VP7 PF00434.18 PIK49070.1 - 0.0074 15.5 12.3 0.67 9.0 0.0 2.8 2 1 1 3 3 3 2 Glycoprotein VP7 HTH_ABP1_N PF18107.1 PIK49070.1 - 0.019 14.7 0.0 62 3.4 0.0 3.3 3 0 0 3 3 3 0 Fission yeast centromere protein N-terminal domain DUF5417 PF17438.2 PIK49070.1 - 0.2 12.0 0.2 0.2 12.0 0.2 2.3 4 0 0 4 4 4 0 Family of unknown function (DUF5417) Epiglycanin_TR PF05647.11 PIK49070.1 - 1.6 8.7 7.8 52 3.8 0.3 3.7 3 0 0 3 3 3 0 Tandem-repeating region of mucin, epiglycanin-like TSP_1 PF00090.19 PIK49071.1 - 1.6e-38 130.7 167.0 3.6e-05 23.9 7.6 13.7 13 0 0 13 13 13 12 Thrombospondin type 1 domain DUF5417 PF17438.2 PIK49071.1 - 1.3e-09 38.3 29.6 0.58 10.5 0.2 7.2 6 0 0 6 6 6 6 Family of unknown function (DUF5417) Cadherin_tail PF15974.5 PIK49071.1 - 0.0017 18.7 18.1 12 6.3 0.1 7.1 7 5 0 7 7 7 3 Cadherin C-terminal cytoplasmic tail, catenin-binding region zf-tcix PF14952.6 PIK49071.1 - 3.4 7.3 50.4 13 5.5 0.8 8.9 7 0 0 7 7 7 0 Putative treble-clef, zinc-finger, Zn-binding Pep_M12B_propep PF01562.19 PIK49072.1 - 6.7e-19 68.5 0.2 9.3e-19 68.0 0.2 1.2 1 0 0 1 1 1 1 Reprolysin family propeptide DUF2475 PF10629.9 PIK49072.1 - 0.0064 16.7 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2475) DUF823 PF05689.11 PIK49072.1 - 0.08 12.7 0.1 0.26 11.0 0.0 1.8 1 1 0 1 1 1 0 Salmonella repeat of unknown function (DUF823) Gp5_C PF06715.12 PIK49073.1 - 0.00035 20.5 5.3 3.1 8.1 0.7 4.7 3 1 0 3 3 3 2 Gp5 C-terminal repeat (3 copies) DUF445 PF04286.12 PIK49073.1 - 0.0012 18.7 5.8 0.0015 18.4 5.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) GerPC PF10737.9 PIK49073.1 - 0.15 12.1 6.8 0.16 12.0 6.0 1.4 1 1 0 1 1 1 0 Spore germination protein GerPC DUF4317 PF14199.6 PIK49073.1 - 0.86 8.7 9.1 1.1 8.3 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) EcsC PF12787.7 PIK49073.1 - 1.1 8.8 8.5 22 4.6 8.4 2.2 1 1 0 1 1 1 0 EcsC protein family DUF3819 PF12842.7 PIK49073.1 - 1.8 8.5 12.2 1.5 8.7 5.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3819) AceK PF06315.11 PIK49073.1 - 2.6 6.4 6.4 2.8 6.3 6.4 1.0 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) DUF697 PF05128.12 PIK49073.1 - 2.9 7.6 12.1 83 2.8 11.6 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF697) COMPASS-Shg1 PF05205.12 PIK49073.1 - 4.7 8.0 15.5 1.3e+03 0.1 15.5 2.4 1 1 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 PIN_8 PF18476.1 PIK49073.1 - 5.6 6.8 8.3 17 5.2 8.3 1.8 1 1 0 1 1 1 0 PIN like domain YTV PF07639.11 PIK49073.1 - 6.5 6.9 7.0 6.5 6.9 2.0 3.0 2 1 0 2 2 2 0 YTV RIFIN PF02009.16 PIK49073.1 - 7.4 6.4 12.5 11 5.9 12.5 1.2 1 0 0 1 1 1 0 Rifin Metallophos PF00149.28 PIK49074.1 - 1.2e-11 45.6 0.0 1.6e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.10 PIK49074.1 - 0.013 14.9 0.2 0.082 12.3 0.2 2.3 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap 5_nucleotid_C PF02872.18 PIK49075.1 - 1.6e-29 103.2 0.0 2e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain LRAT PF04970.13 PIK49077.1 - 8.1e-12 45.6 0.7 9.3e-11 42.1 0.7 2.2 1 1 0 1 1 1 1 Lecithin retinol acyltransferase DUF4064 PF13273.6 PIK49077.1 - 1 9.7 7.7 3 8.2 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) LRAT PF04970.13 PIK49078.1 - 2.2e-10 40.9 2.4 1.1e-08 35.4 2.4 2.5 1 1 0 1 1 1 1 Lecithin retinol acyltransferase CHAP PF05257.16 PIK49078.1 - 0.67 10.6 4.1 0.32 11.6 0.4 2.4 2 1 0 2 2 2 0 CHAP domain Colicin_V PF02674.16 PIK49078.1 - 1.9 8.4 9.9 0.38 10.7 5.4 1.9 1 1 1 2 2 2 0 Colicin V production protein DUF456 PF04306.13 PIK49079.1 - 0.014 15.7 4.4 0.018 15.3 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF456) DUF3566 PF12089.8 PIK49079.1 - 0.017 15.4 1.0 0.017 15.4 1.0 1.8 2 0 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) zf-LITAF-like PF10601.9 PIK49079.1 - 0.02 15.1 4.0 1.7 9.0 0.0 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain OppC_N PF12911.7 PIK49079.1 - 0.042 13.8 2.4 5.4 7.1 0.2 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF2534 PF10749.9 PIK49079.1 - 0.06 13.5 3.4 0.086 13.0 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) DUF4190 PF13828.6 PIK49079.1 - 0.31 10.8 10.3 0.5 10.2 9.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4190) Pox_A14 PF05767.12 PIK49079.1 - 0.41 10.8 6.1 0.58 10.4 6.1 1.4 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF2254 PF10011.9 PIK49079.1 - 0.83 8.4 6.6 1.7 7.4 6.6 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF1700 PF08006.11 PIK49079.1 - 8.3 5.9 8.0 1.6 8.2 4.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1700) EF-hand_1 PF00036.32 PIK49080.1 - 1.7e-19 67.9 9.4 0.00037 19.8 0.2 6.6 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 PIK49080.1 - 6.2e-17 61.8 13.8 6.4e-08 32.9 1.4 4.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 PIK49080.1 - 1.5e-13 49.5 9.8 0.048 13.6 0.1 6.6 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 PIK49080.1 - 9.1e-13 47.1 14.6 0.0025 17.3 0.4 5.3 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 PIK49080.1 - 3.9e-10 39.4 8.3 0.047 13.5 0.0 5.6 5 0 0 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK49080.1 - 0.00046 20.5 4.2 1 9.7 0.0 3.4 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK49080.1 - 0.062 13.3 1.6 1 9.4 0.0 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Peptidase_S24 PF00717.23 PIK49081.1 - 6.4e-09 35.6 0.0 9.2e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like WD40 PF00400.32 PIK49082.1 - 5.5e-09 36.5 1.4 0.055 14.4 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49082.1 - 0.0059 16.9 0.0 2 8.8 0.0 3.4 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CNH PF00780.22 PIK49082.1 - 0.015 14.9 0.6 3 7.4 0.0 2.6 2 1 0 2 2 2 0 CNH domain ADH_zinc_N_2 PF13602.6 PIK49083.1 - 1.2e-20 74.9 0.0 1.9e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 PIK49083.1 - 9.4e-11 41.8 0.0 3e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK49083.1 - 3.4e-05 23.7 0.1 7.4e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 PIK49083.1 - 0.011 15.2 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase Epimerase PF01370.21 PIK49083.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Asp PF00026.23 PIK49084.1 - 2.9e-108 362.0 0.0 3.3e-108 361.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 PIK49084.1 - 1.3e-09 38.6 0.9 5.1e-08 33.4 0.9 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 PIK49084.1 - 1.2e-06 28.4 0.0 3.5e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 PIK49084.1 - 0.047 14.3 0.2 25 5.6 0.0 3.1 2 1 0 2 2 2 0 Aspartyl protease A1_Propeptide PF07966.12 PIK49084.1 - 0.24 11.3 1.8 0.34 10.8 0.8 1.7 2 0 0 2 2 2 0 A1 Propeptide Sulfotransfer_2 PF03567.14 PIK49085.1 - 2.2e-37 129.3 4.2 3.8e-37 128.6 4.2 1.4 1 0 0 1 1 1 1 Sulfotransferase family EGF_CA PF07645.15 PIK49086.1 - 3.4e-156 507.3 496.2 1.9e-09 37.6 10.4 30.5 28 2 2 30 30 29 24 Calcium-binding EGF domain EGF_3 PF12947.7 PIK49086.1 - 1.3e-104 342.0 464.6 1.7e-09 37.7 10.3 30.4 28 1 1 29 29 28 23 EGF domain cEGF PF12662.7 PIK49086.1 - 3.3e-103 337.0 320.6 7.9e-08 32.1 2.7 31.8 31 0 0 31 31 31 25 Complement Clr-like EGF-like EGF PF00008.27 PIK49086.1 - 1.7e-50 168.9 397.2 4.1e-08 33.4 7.7 30.4 29 0 0 29 29 29 21 EGF-like domain hEGF PF12661.7 PIK49086.1 - 5.1e-30 103.0 313.6 1.6e-05 25.3 5.8 30.8 28 2 0 28 28 27 17 Human growth factor-like EGF FXa_inhibition PF14670.6 PIK49086.1 - 3.9e-29 100.6 433.8 2.7e-06 27.6 7.0 30.5 25 4 5 30 30 30 20 Coagulation Factor Xa inhibitory site NIDO PF06119.14 PIK49086.1 - 2e-14 54.3 1.6 6.4e-14 52.7 1.6 2.0 1 0 0 1 1 1 1 Nidogen-like EGF_MSP1_1 PF12946.7 PIK49086.1 - 2.7e-07 30.5 63.4 0.00015 21.7 6.8 27.9 28 0 0 28 28 25 13 MSP1 EGF domain 1 SR-25 PF10500.9 PIK49086.1 - 0.00031 20.5 12.1 0.00054 19.6 12.1 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Zip PF02535.22 PIK49086.1 - 0.002 17.4 0.1 0.0033 16.7 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter SEA PF01390.20 PIK49086.1 - 0.0041 17.2 0.7 0.012 15.7 0.1 2.0 2 0 0 2 2 2 1 SEA domain AP3D1 PF06375.11 PIK49086.1 - 0.067 13.4 9.1 0.13 12.5 9.1 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF3687 PF12459.8 PIK49086.1 - 0.1 12.1 0.4 0.3 10.6 0.4 1.8 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein CPSF100_C PF13299.6 PIK49086.1 - 0.88 9.7 5.2 1.5 9.0 5.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NARP1 PF12569.8 PIK49086.1 - 2.6 6.9 9.2 3.9 6.3 9.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MAP17 PF15807.5 PIK49086.1 - 5.3 7.3 8.3 17 5.7 8.3 1.8 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CMS1 PF14617.6 PIK49086.1 - 6.3 6.1 9.7 11 5.3 9.7 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit RNA_polI_A34 PF08208.11 PIK49086.1 - 7.6 6.6 19.7 2.3 8.2 16.6 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Sec62 PF03839.16 PIK49086.1 - 9.5 5.7 8.5 19 4.7 8.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 POT1PC PF16686.5 PIK49087.1 - 9.8e-47 158.7 0.0 2.1e-22 79.7 0.0 3.3 4 0 0 4 4 4 2 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 PIK49087.1 - 1.3e-27 96.4 0.1 4.7e-26 91.3 0.0 3.0 3 0 0 3 3 3 1 Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon PF01336.25 PIK49087.1 - 0.00067 19.6 0.3 1.9 8.5 0.0 5.1 5 1 1 6 6 6 1 OB-fold nucleic acid binding domain Molybdop_Fe4S4 PF04879.16 PIK49087.1 - 0.031 14.3 0.1 7.5 6.6 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain Rep_fac-A_C PF08646.10 PIK49087.1 - 0.042 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Replication factor-A C terminal domain Glyco_hydro_47 PF01532.20 PIK49088.1 - 1.9e-72 244.7 0.0 2.2e-72 244.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 PIK49088.1 - 0.026 14.0 0.1 0.043 13.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 76 Glyco_hydro_47 PF01532.20 PIK49089.1 - 8.4e-63 212.8 0.0 1.1e-62 212.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Col_cuticle_N PF01484.17 PIK49090.1 - 0.047 13.8 0.2 0.076 13.1 0.2 1.4 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain NICE-3 PF07406.11 PIK49090.1 - 0.064 13.2 0.9 0.091 12.7 0.9 1.2 1 0 0 1 1 1 0 NICE-3 protein G3P_acyltransf PF02660.15 PIK49090.1 - 0.23 11.5 2.7 0.32 11.1 2.7 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Death PF00531.22 PIK49091.1 - 6e-06 26.3 0.0 8.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Death domain DUF4347 PF14252.6 PIK49092.1 - 1.4e-05 25.0 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) IQ PF00612.27 PIK49092.1 - 0.0036 17.0 3.4 0.21 11.5 1.8 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif Galactosyl_T PF01762.21 PIK49093.1 - 1.5e-20 73.9 0.0 1.9e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK49093.1 - 0.016 14.7 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Fringe-like Ycf9 PF01737.17 PIK49094.1 - 0.03 14.2 0.1 0.049 13.5 0.1 1.2 1 0 0 1 1 1 0 YCF9 DUF5534 PF17686.1 PIK49094.1 - 0.26 11.5 0.6 0.39 11.0 0.2 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5534) Oxidored_q2 PF00420.24 PIK49094.1 - 0.3 10.7 1.3 0.42 10.2 1.3 1.5 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Mt_ATP-synt_D PF05873.12 PIK49095.1 - 6.4e-58 195.0 8.8 7.2e-58 194.8 8.8 1.0 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) HrpB2 PF09487.10 PIK49095.1 - 0.0076 16.7 0.7 0.015 15.8 0.1 1.7 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB2) E3_UbLigase_R4 PF13764.6 PIK49095.1 - 0.041 12.1 0.1 0.047 11.9 0.1 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 CENP-O PF09496.10 PIK49095.1 - 0.069 13.1 0.0 0.082 12.9 0.0 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF1241 PF06840.11 PIK49095.1 - 0.1 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) TMF_TATA_bd PF12325.8 PIK49096.1 - 7.1e-32 110.0 12.9 7.1e-32 110.0 12.9 7.4 2 1 6 8 8 8 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 PIK49096.1 - 1.7e-14 53.6 18.6 1.7e-14 53.6 18.6 9.1 4 4 4 8 8 8 2 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 PIK49096.1 - 0.0048 17.2 5.5 0.0048 17.2 5.5 5.7 2 1 4 6 6 6 1 Autophagy protein 16 (ATG16) DUF4250 PF14056.6 PIK49096.1 - 1.6 8.7 13.5 46 4.1 0.1 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4250) Pox_A_type_inc PF04508.12 PIK49096.1 - 2.9 7.9 10.4 15 5.6 0.0 5.2 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat Vip3A_N PF12495.8 PIK49096.1 - 5.6 6.8 15.0 0.091 12.7 0.4 3.5 3 1 1 4 4 4 0 Vegetative insecticide protein 3A N terminal Topoisom_bac PF01131.20 PIK49098.1 - 8.9e-114 380.7 0.0 1.4e-113 380.1 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 PIK49098.1 - 1.7e-19 70.0 0.0 4.5e-19 68.6 0.0 1.8 1 0 0 1 1 1 1 Toprim domain zf-GRF PF06839.12 PIK49098.1 - 1.1e-14 54.2 2.7 1.1e-14 54.2 2.7 2.1 2 0 0 2 2 2 1 GRF zinc finger MoCF_biosynth PF00994.24 PIK49098.1 - 0.17 11.6 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Probable molybdopterin binding domain CCSMST1 PF15013.6 PIK49099.1 - 1e-17 64.1 0.1 1.7e-17 63.3 0.1 1.4 1 0 0 1 1 1 1 CCSMST1 family Histone PF00125.24 PIK49100.1 - 3.3e-53 179.5 1.8 3.7e-53 179.4 1.8 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK49100.1 - 7.5e-05 22.8 0.3 0.00016 21.8 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 PIK49100.1 - 0.00011 22.9 1.7 0.00013 22.5 1.7 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 PIK49100.1 - 0.00026 21.3 0.0 0.0004 20.7 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 PIK49100.1 - 0.064 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 PIK49100.1 - 0.14 12.2 0.1 0.38 10.8 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DUF648 PF04890.13 PIK49101.1 - 0.037 13.8 2.1 0.11 12.3 1.3 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF648) zf-TRAF PF02176.18 PIK49102.1 - 2.2e-17 63.5 24.8 2e-12 47.6 4.8 4.3 2 1 2 4 4 4 2 TRAF-type zinc finger zf-C3HC4_4 PF15227.6 PIK49102.1 - 2.4e-08 34.0 6.2 2.4e-08 34.0 6.2 2.5 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK49102.1 - 1.2e-07 31.4 7.7 1.2e-07 31.4 7.7 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK49102.1 - 3.7e-07 29.9 7.3 3.7e-07 29.9 7.3 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK49102.1 - 5.4e-07 29.5 8.3 5.4e-07 29.5 8.3 2.7 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK49102.1 - 6.6e-06 26.4 6.3 6.6e-06 26.4 6.3 4.0 3 1 1 4 4 1 1 Ring finger domain zf-Nse PF11789.8 PIK49102.1 - 0.00048 19.9 3.4 0.00048 19.9 3.4 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 PIK49102.1 - 0.00053 19.8 7.8 0.00053 19.8 7.8 3.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF_2 PF15965.5 PIK49102.1 - 0.0011 19.3 34.2 0.014 15.8 6.1 5.5 4 1 1 6 6 6 3 TRAF-like zinc-finger Sina PF03145.16 PIK49102.1 - 0.0029 17.6 19.0 0.19 11.6 0.2 4.2 2 1 2 4 4 4 3 Seven in absentia protein family zf-RING_6 PF14835.6 PIK49102.1 - 0.0032 17.3 2.2 0.0032 17.3 2.2 3.3 4 1 0 4 4 4 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 PIK49102.1 - 0.0036 17.2 8.5 0.0036 17.2 8.5 3.6 2 2 2 4 4 2 1 zinc-RING finger domain zf-ACC PF17848.1 PIK49102.1 - 0.081 13.0 6.4 0.16 12.1 0.4 3.8 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain GTP_EFTU_D2 PF03144.25 PIK49104.1 - 0.0057 17.0 2.3 0.0082 16.5 1.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 PIK49104.1 - 0.006 16.9 0.6 0.039 14.2 0.6 2.3 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain AAA_13 PF13166.6 PIK49105.1 - 5.6e-06 25.3 29.5 6.8e-06 25.0 29.5 1.0 1 0 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.9 PIK49105.1 - 0.0002 21.4 13.2 0.0002 21.4 13.2 2.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FYVE PF01363.21 PIK49105.1 - 0.00029 20.9 0.7 0.00069 19.7 0.7 1.7 1 0 0 1 1 1 1 FYVE zinc finger EzrA PF06160.12 PIK49105.1 - 0.003 15.8 31.4 0.02 13.1 9.9 2.1 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA DUF2730 PF10805.8 PIK49105.1 - 0.0047 17.0 1.9 0.0047 17.0 1.9 4.4 1 1 3 4 4 4 2 Protein of unknown function (DUF2730) Lebercilin PF15619.6 PIK49105.1 - 0.007 16.0 44.9 0.059 13.0 11.6 3.5 1 1 1 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease UPF0242 PF06785.11 PIK49105.1 - 0.027 14.6 40.0 0.096 12.8 7.9 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 PIK49105.1 - 0.05 14.1 37.3 0.24 11.8 22.0 2.1 1 1 1 2 2 2 0 Fez1 DUF1192 PF06698.11 PIK49105.1 - 0.056 13.5 0.4 0.056 13.5 0.4 4.5 4 1 1 5 5 4 0 Protein of unknown function (DUF1192) DUF3584 PF12128.8 PIK49105.1 - 0.11 10.0 32.7 0.13 9.7 32.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TMF_TATA_bd PF12325.8 PIK49105.1 - 0.12 12.6 41.1 0.15 12.3 10.0 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 PIK49105.1 - 0.12 12.4 41.9 0.2 11.7 9.1 3.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 PIK49105.1 - 0.19 11.9 43.2 0.16 12.2 30.2 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 PIK49105.1 - 0.22 10.4 42.2 0.27 10.1 29.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein ubiquitin PF00240.23 PIK49105.1 - 0.29 10.9 4.0 1 9.2 1.7 3.1 2 2 0 2 2 2 0 Ubiquitin family ADIP PF11559.8 PIK49105.1 - 0.38 10.8 43.1 1.3 9.1 11.4 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 PIK49105.1 - 0.63 9.3 27.8 0.31 10.4 21.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Rab5-bind PF09311.11 PIK49105.1 - 0.9 8.9 37.1 0.25 10.7 21.3 2.2 1 1 1 2 2 2 0 Rabaptin-like protein DUF1515 PF07439.11 PIK49105.1 - 0.91 9.6 14.0 0.25 11.4 0.9 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1515) Prominin PF05478.11 PIK49105.1 - 0.97 7.3 21.4 1.2 7.0 21.4 1.3 1 0 0 1 1 1 0 Prominin CVNH PF08881.10 PIK49105.1 - 1.3 9.8 7.4 0.68 10.7 1.4 2.6 1 1 1 2 2 2 0 CVNH domain CALCOCO1 PF07888.11 PIK49105.1 - 2.7 6.8 41.1 0.6 8.9 21.6 2.1 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4988 PF16378.5 PIK49105.1 - 2.9 7.5 13.4 0.063 12.9 1.0 2.8 2 1 1 3 3 3 0 Domain of unknown function Fib_alpha PF08702.10 PIK49105.1 - 3.2 7.9 30.3 1.2 9.3 17.5 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 PIK49105.1 - 3.3 7.7 33.3 12 5.9 20.5 2.9 1 1 1 2 2 2 0 Laminin Domain II Golgin_A5 PF09787.9 PIK49105.1 - 3.8 6.9 42.7 2.3e+02 1.0 42.7 2.3 1 1 0 1 1 1 0 Golgin subfamily A member 5 LPP PF04728.13 PIK49105.1 - 6.7 7.2 22.3 6.2 7.3 0.3 5.5 2 1 4 6 6 6 0 Lipoprotein leucine-zipper FPP PF05911.11 PIK49105.1 - 7 4.7 45.3 1.2 7.2 13.3 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil BST2 PF16716.5 PIK49105.1 - 7.9 7.1 37.8 1.1 9.9 2.4 4.9 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 DUF2968 PF11180.8 PIK49105.1 - 8.7 5.9 29.0 2.1 7.9 7.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2968) HAUS-augmin3 PF14932.6 PIK49105.1 - 9 5.8 38.7 0.52 9.9 15.6 2.7 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 GAS PF13851.6 PIK49105.1 - 9.4 5.5 41.5 1.1 8.5 25.5 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FUSC PF04632.12 PIK49105.1 - 9.8 4.6 10.1 15 4.0 9.6 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family LRR_4 PF12799.7 PIK49106.1 - 0.0022 18.4 17.7 0.19 12.2 0.0 6.8 4 2 4 8 8 8 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK49106.1 - 0.039 14.0 16.3 2.3 8.5 0.0 6.6 8 0 0 8 8 8 0 Leucine Rich repeat LRR_5 PF13306.6 PIK49106.1 - 0.3 11.0 6.2 0.21 11.6 1.8 2.9 2 2 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) RRM_1 PF00076.22 PIK49107.1 - 1.5e-07 31.1 0.0 3.3e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 PIK49107.1 - 1.1e-06 28.8 0.0 3.2e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 PWI domain Aida_C2 PF14186.6 PIK49108.1 - 2.3e-58 196.0 0.0 4.6e-58 195.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal adhesion Aida_N PF08910.10 PIK49108.1 - 5.7e-28 97.3 0.1 9e-28 96.7 0.1 1.3 1 0 0 1 1 1 1 Aida N-terminus p450 PF00067.22 PIK49109.1 - 2.6e-84 283.6 0.0 2.5e-83 280.4 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Frtz PF11768.8 PIK49110.1 - 1.6e-179 597.7 0.1 1.9e-179 597.5 0.1 1.0 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Utp13 PF08625.11 PIK49110.1 - 0.15 11.9 0.1 9.8 6.1 0.0 2.5 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain MRI PF15325.6 PIK49110.1 - 7.4 7.7 9.5 3.4 8.8 5.3 2.2 2 0 0 2 2 2 0 Modulator of retrovirus infection Sulfatase PF00884.23 PIK49111.1 - 3e-71 240.3 0.2 9.3e-71 238.7 0.1 1.7 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 PIK49111.1 - 1.5e-25 90.4 1.5 2.8e-25 89.4 1.5 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK49111.1 - 3.6e-08 33.4 0.0 1.6e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK49111.1 - 0.028 13.1 0.0 0.047 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF229) IQ PF00612.27 PIK49112.1 - 2.7e-12 45.3 15.1 3.1e-05 23.4 1.4 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF1481 PF07356.12 PIK49112.1 - 1.3 8.8 7.4 1.1 9.0 0.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1481) CUB PF00431.20 PIK49113.1 - 7.1e-32 110.0 1.0 6.9e-16 58.6 0.0 4.6 4 0 0 4 4 4 3 CUB domain DUF4611 PF15387.6 PIK49113.1 - 0.21 11.8 12.3 1.8 8.9 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) VEGFR-2_TMD PF17988.1 PIK49113.1 - 0.31 10.5 3.4 0.6 9.6 3.4 1.4 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain Voldacs PF03517.13 PIK49113.1 - 1.4 9.1 11.6 1.9 8.6 10.4 1.8 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling Spt5_N PF11942.8 PIK49113.1 - 2.9 8.9 16.8 10 7.2 2.3 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal CENP-B_dimeris PF09026.10 PIK49113.1 - 6.8 7.1 20.2 6.8 7.2 6.4 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CUB PF00431.20 PIK49114.1 - 3e-06 27.5 0.0 0.0016 18.7 0.0 2.3 2 0 0 2 2 2 2 CUB domain Ras PF00071.22 PIK49115.1 - 2.4e-58 196.3 6.0 3.4e-57 192.6 6.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK49115.1 - 1.1e-37 128.8 0.1 2.1e-37 128.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK49115.1 - 2.5e-17 62.9 0.3 3.1e-17 62.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK49115.1 - 1.2e-06 28.1 0.4 1.5e-06 27.8 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK49115.1 - 1.6e-06 27.8 0.7 2.7e-06 27.0 0.4 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK49115.1 - 1.6e-05 24.4 0.2 2.6e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK49115.1 - 1.8e-05 24.8 0.1 2.8e-05 24.2 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK49115.1 - 0.00076 19.4 2.2 0.15 11.9 0.0 3.0 1 1 2 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 PIK49115.1 - 0.021 15.2 0.0 0.035 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 PIK49115.1 - 0.025 14.3 0.3 1.1 9.0 0.0 2.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 PIK49115.1 - 0.041 14.4 0.2 0.074 13.6 0.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA PF00004.29 PIK49115.1 - 0.053 14.0 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK49115.1 - 0.053 13.8 0.0 0.1 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK49115.1 - 0.066 13.0 0.2 0.21 11.4 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 PIK49115.1 - 0.069 12.7 0.3 0.22 11.0 0.0 1.9 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 PIK49115.1 - 0.083 12.9 0.0 0.14 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LANC_like PF05147.13 PIK49115.1 - 0.09 11.3 0.1 0.2 10.2 0.0 1.4 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein BBS2_Mid PF14783.6 PIK49116.1 - 8e-05 22.6 0.1 0.0042 17.1 0.0 3.5 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Itfg2 PF15907.5 PIK49116.1 - 0.00022 20.4 0.1 0.54 9.2 0.0 2.7 3 0 0 3 3 3 2 Integrin-alpha FG-GAP repeat-containing protein 2 VCBS PF13517.6 PIK49116.1 - 0.0031 18.1 0.0 8.4 7.1 0.0 3.1 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella KH_8 PF17903.1 PIK49117.1 - 0.028 14.5 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Krr1 KH1 domain RRP7 PF12923.7 PIK49117.1 - 0.038 14.1 1.4 0.038 14.1 1.4 1.7 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain AAA PF00004.29 PIK49118.1 - 1.7e-40 138.5 0.0 3e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 PIK49118.1 - 1.4e-08 34.6 0.0 3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK49118.1 - 1.1e-06 29.0 0.2 0.01 16.1 0.0 3.5 1 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 PIK49118.1 - 2.3e-06 27.6 0.5 4.9e-05 23.3 0.5 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 PIK49118.1 - 2.3e-06 27.0 0.1 1.6e-05 24.3 0.0 2.0 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_lid_3 PF17862.1 PIK49118.1 - 2.4e-06 27.3 0.4 8.1e-06 25.5 0.0 2.2 2 1 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 PIK49118.1 - 2.7e-05 24.1 0.0 5.7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain TniB PF05621.11 PIK49118.1 - 4.5e-05 23.0 0.1 0.25 10.7 0.0 3.3 2 1 1 3 3 3 2 Bacterial TniB protein AAA_2 PF07724.14 PIK49118.1 - 5.3e-05 23.4 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 PIK49118.1 - 9.6e-05 22.2 0.0 0.00023 20.9 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 PIK49118.1 - 0.00026 21.4 1.4 0.019 15.3 1.4 3.2 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 PIK49118.1 - 0.00031 20.2 1.1 0.0025 17.2 1.1 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 PIK49118.1 - 0.0028 17.7 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 PIK49118.1 - 0.0046 16.2 0.0 0.0073 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.12 PIK49118.1 - 0.007 16.3 0.0 0.054 13.4 0.0 2.1 1 1 1 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK49118.1 - 0.0079 15.8 0.4 0.65 9.5 0.1 2.7 1 1 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 PIK49118.1 - 0.008 16.0 0.0 0.018 14.9 0.0 1.5 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_17 PF13207.6 PIK49118.1 - 0.014 15.8 0.1 0.13 12.6 0.0 2.4 1 1 1 2 2 2 0 AAA domain DUF4368 PF14287.6 PIK49118.1 - 0.02 15.2 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) AAA_33 PF13671.6 PIK49118.1 - 0.027 14.7 0.0 0.085 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK49118.1 - 0.03 14.7 0.0 0.066 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 PIK49118.1 - 0.035 14.6 0.0 0.12 13.0 0.0 1.9 2 1 0 2 2 1 0 AAA domain Guanylate_kin PF00625.21 PIK49118.1 - 0.044 13.5 0.0 0.86 9.3 0.0 2.5 2 1 0 2 2 2 0 Guanylate kinase TsaE PF02367.17 PIK49118.1 - 0.047 13.7 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 PIK49118.1 - 0.072 12.8 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 PIK49118.1 - 0.074 12.4 0.1 8.6 5.6 0.0 2.5 1 1 1 2 2 2 0 KaiC AAA_10 PF12846.7 PIK49118.1 - 0.075 11.9 0.0 0.17 10.8 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain ABC_tran PF00005.27 PIK49118.1 - 0.097 13.2 0.0 0.2 12.2 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Ank_2 PF12796.7 PIK49119.1 - 1.9e-16 60.4 0.2 4.2e-09 36.9 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK49119.1 - 3.9e-14 52.5 0.5 3.2e-12 46.4 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK49119.1 - 1.4e-11 43.5 0.3 0.0041 17.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 PIK49119.1 - 1.7e-11 44.0 2.1 0.0016 18.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 PIK49119.1 - 5.2e-10 39.7 1.5 3.7e-06 27.4 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Plasmodium_HRP PF05403.11 PIK49119.1 - 1.1e-06 28.6 6.4 1.1e-06 28.6 6.4 1.7 2 0 0 2 2 2 1 Plasmodium histidine-rich protein (HRPII/III) z-alpha PF02295.17 PIK49119.1 - 0.047 13.8 0.1 68 3.6 0.0 4.3 1 1 2 4 4 4 0 Adenosine deaminase z-alpha domain VPS9 PF02204.18 PIK49120.1 - 5.4e-22 78.0 0.0 2.2e-21 76.0 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain XPC-binding PF09280.11 PIK49120.1 - 0.018 14.7 0.5 0.078 12.7 0.1 2.2 2 1 0 2 2 2 0 XPC-binding domain MSP7_C PF12948.7 PIK49120.1 - 0.072 13.8 4.1 0.074 13.7 1.1 2.3 2 1 1 3 3 3 0 MSP7-like protein C-terminal domain DUF445 PF04286.12 PIK49120.1 - 0.083 12.7 2.3 0.11 12.3 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Maelstrom PF13017.6 PIK49120.1 - 0.11 12.1 3.8 0.1 12.3 1.9 1.8 2 0 0 2 2 2 0 piRNA pathway germ-plasm component Smr PF01713.21 PIK49120.1 - 0.13 12.7 0.0 0.83 10.1 0.0 2.3 2 0 0 2 2 2 0 Smr domain SASA PF03629.18 PIK49121.1 - 1.3e-05 25.0 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase SASA PF03629.18 PIK49122.1 - 1.1e-12 48.0 0.0 7.2e-11 42.2 0.0 2.6 1 1 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase zf-RVT PF13966.6 PIK49124.1 - 6.7e-05 23.5 2.1 0.00012 22.8 2.1 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase CLCA PF08434.11 PIK49125.1 - 1.3e-44 152.5 0.3 1.5e-44 152.3 0.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal 1-cysPrx_C PF10417.9 PIK49126.1 - 0.01 15.7 0.2 0.029 14.2 0.2 1.7 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin Cuticle_1 PF08140.11 PIK49126.1 - 0.076 13.1 0.1 0.49 10.5 0.0 2.3 2 0 0 2 2 2 0 Crustacean cuticle protein repeat MFS_1 PF07690.16 PIK49127.1 - 1.9e-08 33.6 16.8 4.1e-05 22.7 5.7 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily EB1 PF03271.17 PIK49127.1 - 5.6e-05 23.3 5.7 9.7 6.5 0.0 5.2 5 1 0 5 5 5 3 EB1-like C-terminal motif Csm2_III-A PF03750.13 PIK49127.1 - 0.17 12.7 4.3 66 4.4 0.0 4.3 4 1 0 4 4 4 0 Csm2 Type III-A PdaC PF13739.6 PIK49127.1 - 0.23 12.5 32.7 2.8 9.0 1.0 5.3 2 2 2 4 4 4 0 Deacetylase PdaC HicB-like_2 PF15970.5 PIK49127.1 - 0.35 11.1 5.6 37 4.6 0.0 4.2 5 0 0 5 5 5 0 HicB_like antitoxin of bacterial toxin-antitoxin system AreA_N PF07573.11 PIK49127.1 - 2.7 8.7 10.3 27 5.5 0.2 4.4 4 1 1 5 5 5 0 Nitrogen regulatory protein AreA N terminus Spore_YabQ PF09578.10 PIK49127.1 - 5.2 7.4 11.2 0.16 12.2 3.9 2.3 2 1 1 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) Med9 PF07544.13 PIK49127.1 - 8.8 6.5 17.3 2.4 8.3 0.6 4.4 5 0 0 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 RVT_1 PF00078.27 PIK49128.1 - 0.0052 16.3 0.0 0.013 15.1 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_3 PF13878.6 PIK49128.1 - 4.4 7.2 7.0 0.48 10.3 1.6 2.3 2 1 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Nucleos_tra2_C PF07662.13 PIK49129.1 - 3.1e-81 272.2 1.8 7.4e-81 270.9 1.8 1.7 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 PIK49129.1 - 1e-26 93.3 3.1 1e-26 93.3 3.1 2.3 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus CbiQ PF02361.16 PIK49129.1 - 0.052 13.2 3.0 0.21 11.1 3.0 2.1 1 0 0 1 1 1 0 Cobalt transport protein Cpta_toxin PF07254.12 PIK49129.1 - 0.15 12.1 1.1 0.36 10.8 1.1 1.6 1 0 0 1 1 1 0 Membrane-bound toxin component of toxin-antitoxin system PEMT PF04191.13 PIK49129.1 - 0.6 10.5 4.3 2.3 8.6 0.2 3.3 3 0 0 3 3 3 0 Phospholipid methyltransferase ABC2_membrane PF01061.24 PIK49131.1 - 3e-37 128.1 21.8 3e-37 128.1 21.8 1.3 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 PIK49131.1 - 1.5e-10 40.7 16.2 1.5e-10 40.7 16.2 1.5 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 PIK49131.1 - 1.7e-05 24.3 4.9 1.7e-05 24.3 4.9 1.8 1 1 1 2 2 2 1 ABC-2 family transporter protein PDR_CDR PF06422.12 PIK49131.1 - 0.64 10.0 0.0 0.64 10.0 0.0 3.0 4 0 0 4 4 4 0 CDR ABC transporter FNIP_M PF14637.6 PIK49132.1 - 1.3e-80 270.6 0.5 2.5e-80 269.7 0.5 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 PIK49132.1 - 2.5e-50 170.8 0.2 4.7e-50 169.9 0.2 1.5 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 PIK49132.1 - 6.8e-14 53.1 0.1 2.1e-12 48.3 0.0 4.5 4 2 1 5 5 5 2 Folliculin-interacting protein N-terminus IRF PF00605.17 PIK49134.1 - 6e-38 129.4 2.0 9.5e-38 128.7 2.0 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor fn3 PF00041.21 PIK49136.1 - 4.5e-17 62.2 0.0 2.4e-07 31.0 0.1 3.1 3 0 0 3 3 3 2 Fibronectin type III domain Metallophos PF00149.28 PIK49137.1 - 4.8e-13 50.1 0.1 7.6e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PUL PF08324.11 PIK49138.1 - 1.8e-58 198.0 0.1 2.4e-58 197.6 0.1 1.1 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 PIK49138.1 - 1e-42 145.0 0.2 2e-42 144.0 0.2 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 PIK49138.1 - 6.4e-28 96.4 4.6 7.5e-06 26.6 0.1 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat CbbQ_C PF08406.10 PIK49138.1 - 0.092 13.0 0.4 0.21 11.9 0.4 1.6 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal UQ_con PF00179.26 PIK49139.1 - 3.4e-33 114.3 0.0 6.5e-33 113.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bac_DNA_binding PF00216.21 PIK49139.1 - 0.015 15.5 0.1 0.026 14.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial DNA-binding protein HU-HIG PF18291.1 PIK49139.1 - 0.04 14.0 0.0 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 HU domain fused to wHTH, Ig, or Glycine-rich motif zf-H2C2_2 PF13465.6 PIK49141.1 - 8.8e-13 48.1 20.5 7.8e-06 26.1 0.2 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK49141.1 - 3.7e-08 33.4 25.9 0.00017 21.8 1.1 3.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK49141.1 - 1.6e-06 28.5 27.1 0.0018 19.0 2.4 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK49141.1 - 0.0012 19.0 7.6 0.64 10.4 0.6 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK49141.1 - 0.34 11.4 5.5 0.75 10.3 0.8 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type XPA_N PF01286.18 PIK49141.1 - 0.4 10.8 8.5 1.8 8.7 0.1 2.8 3 0 0 3 3 3 0 XPA protein N-terminal zf_UBZ PF18439.1 PIK49141.1 - 0.53 9.9 4.7 4.4 7.0 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 PIK49141.1 - 2.4 8.3 7.4 2.8 8.0 3.3 2.6 2 0 0 2 2 2 0 BED zinc finger Laminin_G_2 PF02210.24 PIK49142.1 - 3.7e-75 250.5 6.5 4e-21 75.9 0.1 4.2 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 PIK49142.1 - 1.9e-73 244.8 0.7 1.7e-19 70.4 0.0 4.2 4 0 0 4 4 4 4 Laminin G domain EGF PF00008.27 PIK49142.1 - 9e-24 83.4 87.5 9.6e-09 35.4 3.3 7.6 7 0 0 7 7 7 6 EGF-like domain hEGF PF12661.7 PIK49142.1 - 4.6e-17 62.0 69.9 4.4e-05 23.9 1.5 8.1 7 0 0 7 7 7 6 Human growth factor-like EGF Laminin_G_3 PF13385.6 PIK49142.1 - 6.1e-06 26.4 5.4 0.0011 19.2 0.1 3.8 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily EGF_CA PF07645.15 PIK49142.1 - 0.0037 17.4 8.8 0.0037 17.4 8.8 7.6 4 3 3 7 7 7 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK49142.1 - 0.011 15.9 10.0 0.011 15.9 10.0 7.4 7 0 0 7 7 7 0 EGF domain PGM1_C PF18105.1 PIK49142.1 - 0.14 11.7 0.1 13 5.4 0.0 2.6 2 0 0 2 2 2 0 PGM1 C-terminal domain EGF PF00008.27 PIK49143.1 - 4e-126 410.7 361.2 1.3e-06 28.5 5.8 27.8 28 0 0 28 28 28 27 EGF-like domain hEGF PF12661.7 PIK49143.1 - 4.6e-41 138.1 298.9 1.1e-06 29.0 5.9 28.1 27 0 0 27 27 27 21 Human growth factor-like EGF EGF_2 PF07974.13 PIK49143.1 - 7.8e-05 23.0 377.9 0.014 15.8 8.8 25.9 25 0 0 25 25 25 15 EGF-like domain Laminin_G_2 PF02210.24 PIK49143.1 - 0.0014 19.2 0.0 0.0021 18.6 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain EGF_3 PF12947.7 PIK49143.1 - 0.0092 16.2 4.9 0.0092 16.2 4.9 26.1 23 4 3 26 26 26 16 EGF domain Laminin_G_1 PF00054.23 PIK49143.1 - 0.033 14.4 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain EGF PF00008.27 PIK49144.1 - 4.5e-122 397.7 245.9 5.5e-10 39.4 6.0 18.5 18 0 0 18 18 18 18 EGF-like domain hEGF PF12661.7 PIK49144.1 - 3.9e-90 293.7 212.2 5.9e-07 29.9 4.2 21.2 19 1 0 19 19 19 17 Human growth factor-like EGF EGF_CA PF07645.15 PIK49144.1 - 3.2e-39 132.9 262.9 5.4e-05 23.3 11.2 18.4 11 6 7 18 18 18 16 Calcium-binding EGF domain EGF_2 PF07974.13 PIK49144.1 - 5.4e-11 42.7 294.4 0.0059 16.9 4.6 18.9 18 1 1 19 19 19 12 EGF-like domain EGF_3 PF12947.7 PIK49144.1 - 2.4e-07 30.9 220.8 0.0095 16.1 2.0 18.8 12 5 5 17 17 17 12 EGF domain FXa_inhibition PF14670.6 PIK49144.1 - 0.00015 21.9 227.6 0.12 12.6 6.8 18.3 10 5 8 18 18 18 10 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK49144.1 - 0.011 15.7 2.9 0.011 15.7 2.9 22.4 21 5 0 21 21 21 0 Complement Clr-like EGF-like EGF PF00008.27 PIK49145.1 - 7.3e-56 186.0 98.3 2.2e-09 37.5 9.4 10.2 9 1 0 9 9 9 8 EGF-like domain hEGF PF12661.7 PIK49145.1 - 1.2e-40 136.8 91.1 6.3e-08 33.0 6.0 10.9 12 0 0 12 12 12 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK49145.1 - 2.1e-23 82.2 113.9 9.3e-06 25.8 8.7 9.4 7 2 2 9 9 9 7 Calcium-binding EGF domain EGF_3 PF12947.7 PIK49145.1 - 8e-13 48.4 94.0 0.005 17.0 6.0 9.0 6 2 2 8 8 8 7 EGF domain FXa_inhibition PF14670.6 PIK49145.1 - 2.3e-11 43.8 88.3 0.031 14.5 2.9 9.2 3 3 6 9 9 9 6 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK49145.1 - 9.9e-10 38.6 110.7 0.0018 18.6 9.7 8.8 9 0 0 9 9 9 8 EGF-like domain cEGF PF12662.7 PIK49145.1 - 2.5e-09 36.9 96.0 0.00069 19.5 1.5 11.1 11 1 0 11 11 11 6 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK49145.1 - 0.003 17.7 92.7 2.3 8.4 3.2 8.3 3 3 5 8 8 8 3 Laminin EGF domain EGF PF00008.27 PIK49146.1 - 2.2e-71 235.6 133.8 1.3e-08 35.0 5.7 11.8 11 0 0 11 11 11 10 EGF-like domain hEGF PF12661.7 PIK49146.1 - 4.5e-37 125.4 141.6 5e-06 26.9 5.0 14.9 16 0 0 16 16 16 10 Human growth factor-like EGF EGF_CA PF07645.15 PIK49146.1 - 3.9e-12 46.2 144.1 0.0002 21.5 4.4 11.7 6 4 4 10 10 10 8 Calcium-binding EGF domain EGF_3 PF12947.7 PIK49146.1 - 1.8e-10 40.8 114.4 0.018 15.3 1.6 11.9 6 4 4 10 10 10 5 EGF domain Ldl_recept_a PF00057.18 PIK49146.1 - 6e-08 32.8 7.2 6e-08 32.8 7.2 8.9 9 1 1 10 10 10 1 Low-density lipoprotein receptor domain class A EGF_2 PF07974.13 PIK49146.1 - 1.7e-06 28.3 161.3 0.014 15.8 10.6 11.7 11 0 0 11 11 11 8 EGF-like domain FXa_inhibition PF14670.6 PIK49146.1 - 4.3e-06 26.9 120.8 0.018 15.3 4.3 10.8 4 1 6 10 10 10 5 Coagulation Factor Xa inhibitory site ADK PF00406.22 PIK49147.1 - 3.5e-46 157.0 0.0 4.3e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 PIK49147.1 - 6.9e-36 123.7 0.0 1e-35 123.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK49147.1 - 8.4e-09 36.1 0.0 1.5e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK49147.1 - 5.6e-06 26.6 0.0 1.1e-05 25.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 PIK49147.1 - 5.8e-06 26.1 0.2 0.016 14.9 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 PIK49147.1 - 0.0017 17.7 0.0 0.0044 16.3 0.0 1.8 1 1 0 1 1 1 1 Zeta toxin dNK PF01712.19 PIK49147.1 - 0.0024 17.7 0.3 0.012 15.5 0.1 1.9 2 0 0 2 2 2 1 Deoxynucleoside kinase Cytidylate_kin PF02224.18 PIK49147.1 - 0.083 12.6 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 PIK49147.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 NTPase NACHT PF05729.12 PIK49147.1 - 0.15 12.0 0.5 17 5.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Calreticulin PF00262.18 PIK49148.1 - 4.6e-82 275.8 16.9 2.9e-61 207.3 5.9 2.6 2 1 1 3 3 3 2 Calreticulin family GMP_PDE_delta PF05351.11 PIK49148.1 - 0.17 11.9 2.8 6.5 6.8 0.0 2.6 2 0 0 2 2 2 0 GMP-PDE, delta subunit Smac_DIABLO PF09057.10 PIK49148.1 - 0.25 10.7 5.7 0.38 10.1 5.7 1.2 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases MDM10 PF12519.8 PIK49148.1 - 4.3 6.1 4.6 6 5.6 4.6 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Laminin_N PF00055.17 PIK49149.1 - 4.2e-39 134.5 0.0 7.3e-39 133.7 0.0 1.3 1 1 0 1 1 1 1 Laminin N-terminal (Domain VI) Tme5_EGF_like PF09064.10 PIK49149.1 - 0.19 11.6 3.4 0.41 10.6 3.4 1.6 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like BNR PF02012.20 PIK49149.1 - 1.1 9.5 3.1 1.2 9.4 0.0 2.7 3 0 0 3 3 3 0 BNR/Asp-box repeat RVT_2 PF07727.14 PIK49150.1 - 3.8e-53 180.6 0.0 5e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 PIK49151.1 - 1.7e-18 67.2 0.1 3.4e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK49152.1 - 6.5e-17 61.8 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK49152.1 - 3.3e-15 55.9 0.0 6.6e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK49152.1 - 3.2e-06 27.4 0.0 9.9e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK49152.1 - 0.00042 20.0 0.0 0.00096 18.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK49152.1 - 0.0049 17.0 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger HAUS4 PF14735.6 PIK49152.1 - 0.15 11.7 2.4 0.3 10.7 0.2 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 Linker_histone PF00538.19 PIK49152.1 - 1.6 9.2 4.0 4.9 7.6 0.7 2.5 2 0 0 2 2 2 0 linker histone H1 and H5 family Peptidase_M48 PF01435.18 PIK49153.1 - 6.9e-15 55.3 0.0 2.1e-11 44.0 0.0 2.3 1 1 1 2 2 2 2 Peptidase family M48 Vps55 PF04133.14 PIK49154.1 - 5.4e-35 119.9 10.2 8.2e-35 119.3 10.2 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting 55 PAP_assoc PF03828.19 PIK49155.1 - 7.2e-22 77.4 0.1 4.6e-14 52.4 0.2 3.1 3 0 0 3 3 3 2 Cid1 family poly A polymerase zf-CCHC PF00098.23 PIK49155.1 - 3.1e-10 39.6 10.1 9.2e-05 22.3 1.4 2.8 2 0 0 2 2 2 2 Zinc knuckle NTP_transf_2 PF01909.23 PIK49155.1 - 0.00019 21.7 0.0 0.00062 20.0 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain zf-CCHC_2 PF13696.6 PIK49155.1 - 0.00052 19.8 5.1 0.00052 19.8 5.1 3.6 3 0 0 3 3 3 1 Zinc knuckle Polbeta PF18765.1 PIK49155.1 - 0.0028 17.7 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase zf-C2H2_2 PF12756.7 PIK49155.1 - 0.014 15.7 0.5 0.052 13.9 0.5 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-CCHC_6 PF15288.6 PIK49155.1 - 0.28 11.0 4.8 0.17 11.8 0.6 2.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK49155.1 - 0.97 9.2 15.8 0.32 10.8 0.1 3.4 5 0 0 5 5 5 0 Zinc knuckle Mucin PF01456.17 PIK49155.1 - 5.5 7.0 10.4 19 5.2 10.4 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein ADIP PF11559.8 PIK49156.1 - 1.2e-26 93.7 21.1 1.2e-26 93.7 21.1 4.8 5 1 0 5 5 5 1 Afadin- and alpha -actinin-Binding APG17 PF04108.12 PIK49156.1 - 0.0005 19.3 1.5 0.0005 19.3 1.5 3.5 2 1 1 3 3 3 1 Autophagy protein Apg17 AKNA PF12443.8 PIK49156.1 - 0.0029 18.2 0.8 0.0029 18.2 0.8 6.0 4 2 4 8 8 8 1 AT-hook-containing transcription factor Med9 PF07544.13 PIK49156.1 - 0.5 10.5 34.3 1.2 9.3 0.4 4.9 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Prion PF00377.18 PIK49157.1 - 0.43 10.4 2.7 4 7.3 0.1 2.6 2 1 0 2 2 2 0 Prion/Doppel alpha-helical domain Axin_b-cat_bind PF08833.10 PIK49157.1 - 1.4 9.1 24.2 15 5.7 0.2 6.5 7 0 0 7 7 7 0 Axin beta-catenin binding domain YflT PF11181.8 PIK49157.1 - 3.7 8.1 7.3 10 6.7 0.6 2.7 2 0 0 2 2 2 0 Heat induced stress protein YflT KduI PF04962.12 PIK49158.1 - 0.12 11.7 5.0 0.41 9.9 0.3 2.8 2 1 0 3 3 3 0 KduI/IolB family 7tm_1 PF00001.21 PIK49159.1 - 4.1e-37 127.9 20.6 5.4e-37 127.5 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK49159.1 - 8.5e-12 45.3 25.4 9.7e-12 45.1 25.4 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK49159.1 - 6.4e-05 22.5 25.4 0.00013 21.4 25.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK49159.1 - 0.00031 20.2 19.4 0.00037 20.0 18.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Pyridoxal_deC PF00282.19 PIK49160.1 - 3.8e-27 95.0 0.2 4.7e-27 94.7 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain PPPI_inhib PF14895.6 PIK49160.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 inhibitor SelK_SelG PF10961.8 PIK49161.1 - 0.0038 17.8 0.3 0.0088 16.6 0.3 1.6 1 0 0 1 1 1 1 Selenoprotein SelK_SelG FAA_hydrolase PF01557.18 PIK49163.1 - 1.3e-55 188.4 0.0 1.7e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 PIK49163.1 - 4.6e-05 23.6 0.0 0.00014 22.0 0.0 1.7 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal Laminin_EGF PF00053.24 PIK49164.1 - 7.1e-24 83.7 205.8 0.0022 18.1 14.0 12.9 3 2 9 12 12 12 10 Laminin EGF domain hEGF PF12661.7 PIK49164.1 - 4.3e-21 74.7 160.3 5.8e-05 23.6 6.9 16.2 14 2 0 14 14 14 11 Human growth factor-like EGF DSL PF01414.19 PIK49164.1 - 8.1e-11 42.0 231.6 0.00079 19.7 11.0 11.4 11 0 0 11 11 11 10 Delta serrate ligand EGF_2 PF07974.13 PIK49164.1 - 3.1e-05 24.2 259.2 0.0036 17.6 12.5 20.1 16 6 2 18 18 18 8 EGF-like domain EGF PF00008.27 PIK49164.1 - 0.00071 19.8 44.9 0.0023 18.2 9.9 15.6 18 0 0 18 18 18 9 EGF-like domain Laminin_EGF PF00053.24 PIK49165.1 - 6.7e-13 48.6 154.5 0.011 15.9 12.6 9.8 7 2 2 9 9 9 8 Laminin EGF domain EGF_2 PF07974.13 PIK49165.1 - 1.9e-11 44.1 179.3 0.0031 17.8 12.6 14.6 11 5 3 14 14 14 7 EGF-like domain hEGF PF12661.7 PIK49165.1 - 1.3e-10 41.5 146.0 0.00064 20.3 4.8 12.9 12 2 2 14 14 14 8 Human growth factor-like EGF DSL PF01414.19 PIK49165.1 - 2.3e-05 24.6 152.1 0.0054 17.0 13.8 8.6 7 1 2 9 9 9 6 Delta serrate ligand EGF PF00008.27 PIK49165.1 - 0.015 15.6 154.0 0.077 13.3 10.1 11.1 12 2 0 12 12 12 0 EGF-like domain Laminin_EGF PF00053.24 PIK49166.1 - 2.9e-08 33.7 45.9 0.018 15.2 14.5 4.0 1 1 2 3 3 3 3 Laminin EGF domain hEGF PF12661.7 PIK49166.1 - 0.00069 20.2 4.8 0.00069 20.2 4.8 6.2 5 2 0 5 5 5 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK49166.1 - 0.14 12.5 50.2 0.21 12.0 0.9 5.9 4 3 0 4 4 4 0 EGF-like domain Patched PF02460.18 PIK49167.1 - 1.7e-118 396.9 20.9 1.9e-118 396.7 20.9 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK49167.1 - 4.9e-20 71.9 0.7 4.9e-20 71.9 0.7 3.4 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 PIK49167.1 - 0.0017 16.1 15.1 0.0022 15.7 15.1 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 PIK49167.1 - 0.061 12.2 18.5 1.2 8.0 0.2 2.2 2 0 0 2 2 2 0 MMPL family FYVE PF01363.21 PIK49169.1 - 4.5e-17 61.9 20.2 1.2e-16 60.5 20.2 1.8 1 0 0 1 1 1 1 FYVE zinc finger Spc7 PF08317.11 PIK49169.1 - 0.011 14.6 55.5 0.59 9.0 21.0 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein PSD2 PF07624.11 PIK49169.1 - 0.074 12.8 0.7 0.47 10.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) IBR PF01485.21 PIK49169.1 - 1.2 9.4 16.8 0.38 11.0 12.2 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain HIP1_clath_bdg PF16515.5 PIK49169.1 - 1.3 9.7 44.6 0.65 10.6 10.5 4.0 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4985 PF16373.5 PIK49169.1 - 1.9 9.0 4.7 0.92 10.0 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function DUF4201 PF13870.6 PIK49169.1 - 4 7.1 46.0 0.026 14.3 18.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF3037 PF11236.8 PIK49169.1 - 8.6 6.8 10.5 11 6.5 0.8 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) TPR_MLP1_2 PF07926.12 PIK49170.1 - 3.9 7.5 56.5 0.18 11.9 10.3 5.2 3 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein DSPc PF00782.20 PIK49170.1 - 7.3 6.4 6.8 1.7 8.5 0.4 2.6 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain RUN PF02759.19 PIK49171.1 - 5.5e-12 45.8 0.0 1.1e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 RUN domain ATG16 PF08614.11 PIK49171.1 - 2.3e-05 24.7 0.1 4e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.6 PIK49171.1 - 0.32 11.4 3.6 0.35 11.3 1.8 2.0 2 0 0 2 2 2 0 Snapin/Pallidin ABC_tran_CTD PF16326.5 PIK49171.1 - 0.38 11.0 3.8 5.4 7.3 2.6 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4404 PF14357.6 PIK49171.1 - 0.45 11.2 2.1 0.86 10.3 1.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) 2-Hacid_dh_C PF02826.19 PIK49172.1 - 1.2e-43 148.6 0.0 1.7e-43 148.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK49172.1 - 8.2e-05 22.3 0.0 0.00017 21.3 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ThiF PF00899.21 PIK49172.1 - 0.00015 21.2 0.0 0.00032 20.1 0.0 1.5 2 0 0 2 2 2 1 ThiF family Pyr_redox_2 PF07992.14 PIK49172.1 - 0.00057 19.2 0.0 0.0009 18.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 PIK49172.1 - 0.00059 19.9 0.0 0.0028 17.7 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Oxidored_nitro PF00148.19 PIK49172.1 - 0.00062 18.6 0.0 0.00081 18.2 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase F420_oxidored PF03807.17 PIK49172.1 - 0.00065 20.2 0.0 0.0017 18.9 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 PIK49172.1 - 0.00085 19.5 0.0 0.0022 18.2 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox PF00070.27 PIK49172.1 - 0.00092 19.7 0.0 0.0023 18.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Glyco_transf_10 PF00852.19 PIK49173.1 - 8.3e-54 182.0 0.2 1.2e-53 181.4 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK49173.1 - 0.0081 16.6 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal PIP5K PF01504.18 PIK49174.1 - 6.8e-76 255.1 1.3 1.6e-75 253.8 0.0 2.1 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase RRM_1 PF00076.22 PIK49175.1 - 0.035 13.9 0.1 0.084 12.7 0.1 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pep1_7 PF17232.2 PIK49175.1 - 1.2 9.6 7.7 3.8 8.0 1.2 2.7 2 1 0 2 2 2 0 Elicitor peptide 1-7 RabGAP-TBC PF00566.18 PIK49176.1 - 6e-44 150.3 2.1 7.7e-44 149.9 2.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 PIK49177.1 - 0.00077 19.0 0.1 0.0016 18.0 0.1 1.5 1 0 0 1 1 1 1 Rab-binding domain (RBD) GDPD PF03009.17 PIK49178.1 - 1.1e-29 104.0 0.0 1.6e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF1712 PF08217.11 PIK49179.1 - 3.3e-46 158.0 13.9 1.7e-39 135.8 7.3 3.1 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) Hrs_helical PF12210.8 PIK49180.1 - 3.8e-38 129.9 7.3 3.8e-38 129.9 7.3 3.3 3 1 0 3 3 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate VHS PF00790.19 PIK49180.1 - 7.6e-33 113.3 0.2 7.6e-33 113.3 0.2 3.3 3 1 0 3 3 3 1 VHS domain FYVE PF01363.21 PIK49180.1 - 2.7e-17 62.6 8.9 6.3e-17 61.5 8.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 PIK49180.1 - 0.0017 18.6 3.1 0.0017 18.6 3.1 3.1 2 1 0 2 2 1 1 FYVE-type zinc finger IBR PF01485.21 PIK49180.1 - 0.26 11.5 6.4 0.54 10.5 4.6 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain UIM PF02809.20 PIK49180.1 - 1.9 8.6 12.9 0.041 13.8 5.3 2.4 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF4824 PF16106.5 PIK49180.1 - 2.3 7.4 17.1 4.2 6.5 17.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) Glyphos_transf PF04464.14 PIK49180.1 - 2.9 6.8 5.2 19 4.1 0.0 2.4 2 1 0 2 2 2 0 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase zf-AN1 PF01428.16 PIK49180.1 - 3.3 7.9 12.1 7.6 6.8 12.1 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger Macoilin PF09726.9 PIK49180.1 - 3.4 6.1 25.1 7.9 4.9 25.1 1.5 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 PIK49180.1 - 3.5 6.9 14.9 7.2 5.9 14.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EAP30 PF04157.16 PIK49180.1 - 6.6 5.9 11.4 13 5.0 11.4 1.4 1 0 0 1 1 1 0 EAP30/Vps36 family Arf PF00025.21 PIK49181.1 - 5e-19 68.4 0.0 5.6e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family NOG1 PF06858.14 PIK49181.1 - 0.0062 16.3 0.2 0.012 15.3 0.2 1.5 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) Sulfate_transp PF00916.20 PIK49182.1 - 3.3e-102 342.1 12.1 4.1e-102 341.8 12.1 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 PIK49182.1 - 0.0001 21.9 0.1 0.00024 20.7 0.1 1.6 1 0 0 1 1 1 1 STAS domain Dak1_2 PF13684.6 PIK49182.1 - 0.058 12.5 0.1 0.088 11.9 0.1 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family TrpP PF17099.5 PIK49182.1 - 0.24 11.1 7.9 0.058 13.2 1.4 2.6 2 0 0 2 2 2 0 Tryptophan transporter TrpP DEAD PF00270.29 PIK49183.1 - 1.9e-49 167.8 0.0 3.3e-49 167.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK49183.1 - 1e-29 103.1 0.0 2.5e-29 101.9 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK49183.1 - 0.019 15.0 0.0 0.049 13.6 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK49184.1 - 1.7e-48 164.7 0.0 4.9e-48 163.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK49184.1 - 5.5e-29 100.8 0.0 2.6e-28 98.6 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK49184.1 - 0.0005 20.1 0.0 0.0015 18.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 PIK49184.1 - 0.12 12.7 0.0 14 6.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DEC-1_N PF04625.13 PIK49184.1 - 1.3 7.9 17.6 2.4 7.1 17.6 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF3967 PF13152.6 PIK49184.1 - 1.5 8.7 6.3 2.5 8.0 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3967) PRD1_DD PF11087.8 PIK49186.1 - 7.3 6.4 12.1 2.7 7.8 0.6 3.4 3 0 0 3 3 3 0 PRD1 phage membrane DNA delivery Myosin_head PF00063.21 PIK49187.1 - 6.5e-80 269.2 0.0 3.3e-42 144.6 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 PIK49187.1 - 7.7e-05 23.1 0.0 0.00027 21.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK49187.1 - 0.0043 17.3 0.3 0.029 14.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain IQ PF00612.27 PIK49187.1 - 0.024 14.4 1.6 0.06 13.2 1.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF87 PF01935.17 PIK49187.1 - 0.033 14.3 0.7 0.39 10.8 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain Torsin PF06309.11 PIK49187.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Torsin Kinesin PF00225.23 PIK49187.1 - 0.074 12.0 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinesin motor domain ATPase PF06745.13 PIK49187.1 - 0.34 10.2 0.7 15 4.9 0.1 2.4 2 0 0 2 2 2 0 KaiC 7tm_2 PF00002.24 PIK49188.1 - 5.8e-34 117.5 22.5 7.9e-34 117.0 22.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK49188.1 - 4e-14 52.8 1.0 8.4e-14 51.8 1.0 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK49188.1 - 4.5e-05 23.0 6.3 0.00015 21.3 5.5 2.3 2 1 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain Ig_3 PF13927.6 PIK49188.1 - 0.00012 22.6 0.0 0.00031 21.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49188.1 - 0.03 14.6 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_6 PF18452.1 PIK49188.1 - 0.16 11.6 0.0 0.45 10.1 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ost5 PF05251.12 PIK49188.1 - 0.44 10.8 6.0 0.75 10.1 0.3 3.1 2 1 0 2 2 2 0 Oligosaccharyltransferase subunit 5 TraL PF07178.11 PIK49188.1 - 7.8 7.0 6.5 0.49 10.9 0.3 2.3 2 1 0 2 2 2 0 TraL protein Pkinase_Tyr PF07714.17 PIK49189.1 - 9.9e-86 287.2 0.0 1.4e-85 286.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49189.1 - 5.9e-28 98.0 0.0 9.4e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Adeno_E3_CR2 PF02439.15 PIK49189.1 - 0.15 11.9 5.7 0.31 10.8 5.7 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ank_2 PF12796.7 PIK49190.1 - 1.5e-11 44.7 0.0 1.1e-08 35.5 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK49190.1 - 5.1e-09 36.5 0.0 7.8e-05 23.1 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK49190.1 - 5.9e-05 23.3 0.0 0.017 15.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 PIK49190.1 - 0.00089 19.5 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK49190.1 - 0.0061 17.0 0.0 2.7 8.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat FlxA PF14282.6 PIK49190.1 - 0.037 14.0 0.2 0.037 14.0 0.2 1.7 2 0 0 2 2 2 0 FlxA-like protein Pribosyltran PF00156.27 PIK49191.1 - 1.4e-25 89.7 0.0 1.8e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 PIK49191.1 - 0.0019 17.8 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.6 PIK49191.1 - 0.0026 17.2 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Enkurin PF13864.6 PIK49192.1 - 4.5e-29 100.8 11.0 4.5e-29 100.8 11.0 1.9 2 0 0 2 2 2 1 Calmodulin-binding Kazal_2 PF07648.15 PIK49195.1 - 3.3e-08 33.5 14.5 2.2e-06 27.7 5.0 4.8 4 1 0 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK49195.1 - 1.1e-06 28.5 16.9 0.00025 21.0 3.4 3.4 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Pacifastin_I PF05375.13 PIK49195.1 - 0.00012 21.7 1.4 0.00012 21.7 1.4 3.3 3 0 0 3 3 3 1 Pacifastin inhibitor (LCMII) fn3 PF00041.21 PIK49197.1 - 8.3e-11 42.1 0.7 1.2e-06 28.8 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain LRR_8 PF13855.6 PIK49198.1 - 3.4e-13 49.1 2.4 3.9e-06 26.5 0.1 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK49198.1 - 8.8e-08 32.3 2.3 0.0061 16.9 0.1 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK49198.1 - 4e-06 26.6 0.2 0.036 14.6 0.0 3.8 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK49198.1 - 0.031 14.3 0.6 7.6 6.9 0.1 2.8 2 0 0 2 2 2 0 Leucine Rich repeat NRN1 PF15056.6 PIK49201.1 - 0.056 13.5 0.0 0.064 13.3 0.0 1.1 1 0 0 1 1 1 0 Neuritin protein family WXG100 PF06013.12 PIK49202.1 - 2.7 8.3 5.6 24 5.3 0.1 3.1 3 0 0 3 3 3 0 Proteins of 100 residues with WXG BTB PF00651.31 PIK49203.1 - 2.4e-20 72.8 0.0 3.4e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK49204.1 - 5.4e-15 55.6 2.0 1.5e-14 54.2 0.2 2.6 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.15 PIK49204.1 - 9.8e-06 25.6 2.9 9.8e-06 25.6 2.9 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 PIK49205.1 - 1.3e-18 67.3 0.1 4.4e-18 65.5 0.1 1.8 1 1 1 2 2 2 1 BTB/POZ domain Met_gamma_lyase PF06838.11 PIK49205.1 - 0.18 10.3 0.0 0.21 10.0 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase BACK PF07707.15 PIK49206.1 - 0.00015 21.8 4.8 0.00026 21.0 4.8 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch Swi6_N PF18530.1 PIK49206.1 - 0.062 13.4 1.0 0.74 10.0 0.2 2.3 1 1 1 2 2 2 0 Swi6 N-terminal domain BTB PF00651.31 PIK49207.1 - 1.4e-13 51.0 0.5 1.8e-11 44.2 0.5 2.6 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK49207.1 - 0.0013 18.8 8.8 0.0015 18.6 4.9 2.3 1 1 1 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.31 PIK49208.1 - 1.9e-16 60.2 0.8 6.3e-16 58.6 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK49208.1 - 1.5e-05 25.0 6.6 0.00017 21.6 3.0 2.4 1 1 1 2 2 2 2 BTB And C-terminal Kelch AIP3 PF03915.13 PIK49209.1 - 1e-12 47.9 0.6 1.3e-12 47.6 0.0 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 DUF4329 PF14220.6 PIK49209.1 - 0.36 10.9 3.0 2.5 8.1 2.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4329) Fibrinogen_C PF00147.18 PIK49211.1 - 4.6e-08 33.1 1.3 1.8e-07 31.2 0.1 2.0 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK49211.1 - 2.2e-05 24.6 10.4 2.2e-05 24.6 10.4 4.0 2 2 1 3 3 3 1 EGF domain TIL PF01826.17 PIK49211.1 - 3.8e-05 23.9 7.8 3.8e-05 23.9 7.8 3.8 2 1 2 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK49211.1 - 0.00031 20.6 6.3 0.00031 20.6 6.3 3.6 3 1 0 3 3 3 1 TILa domain EGF_MSP1_1 PF12946.7 PIK49211.1 - 0.0079 16.2 19.6 0.012 15.7 6.4 3.3 3 0 0 3 3 3 2 MSP1 EGF domain 1 EB PF01683.18 PIK49211.1 - 0.98 9.8 29.9 6.6 7.1 4.7 3.4 1 1 1 2 2 2 0 EB module EGF_CA PF07645.15 PIK49211.1 - 3.4 7.9 29.3 0.55 10.5 11.1 3.6 2 1 1 3 3 3 0 Calcium-binding EGF domain cEGF PF12662.7 PIK49211.1 - 8.4 6.4 27.1 0.11 12.5 3.2 4.4 4 1 0 4 4 4 0 Complement Clr-like EGF-like Peroxin-13_N PF04088.13 PIK49212.1 - 4.3e-44 150.3 0.0 6.4e-44 149.7 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 PIK49212.1 - 3e-08 33.4 0.0 5.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK49212.1 - 3.3e-06 26.6 0.0 5.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK49212.1 - 0.0023 17.6 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain TPR_2 PF07719.17 PIK49213.1 - 1.1e-06 28.3 0.0 0.026 14.6 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49213.1 - 0.0021 17.8 0.0 0.37 10.7 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK49213.1 - 0.0029 17.9 0.0 0.42 10.9 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49213.1 - 0.0034 17.9 0.0 9.6 6.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49213.1 - 0.0045 17.1 0.0 0.48 10.8 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK49213.1 - 0.064 12.6 0.0 0.36 10.1 0.0 2.0 2 0 0 2 2 2 0 MalT-like TPR region Peptidase_S41_N PF11918.8 PIK49213.1 - 0.084 13.1 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Med23 PF11573.8 PIK49214.1 - 5.2e-94 316.0 0.6 6.3e-94 315.7 0.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 Med23 PF11573.8 PIK49215.1 - 6.2e-43 146.8 3.7 3.7e-21 74.6 0.8 2.0 1 1 1 2 2 2 2 Mediator complex subunit 23 Med23 PF11573.8 PIK49216.1 - 7.6e-129 431.4 0.4 8.9e-129 431.2 0.4 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 Med23 PF11573.8 PIK49217.1 - 1.6e-89 301.1 4.3 3.2e-52 177.6 0.3 2.0 1 1 1 2 2 2 2 Mediator complex subunit 23 DUF684 PF05075.14 PIK49217.1 - 0.0095 15.0 0.0 2.1 7.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF684) CNDH2_M PF16869.5 PIK49217.1 - 0.023 15.4 0.0 7.9 7.2 0.0 2.2 2 0 0 2 2 2 0 PF16858 FlaC_arch PF05377.11 PIK49217.1 - 0.16 12.4 0.0 33 5.0 0.0 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) GIT_CC PF16559.5 PIK49217.1 - 0.69 9.8 3.7 18 5.3 0.3 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor GMC_oxred_N PF00732.19 PIK49218.1 - 1.1e-93 313.9 0.0 1.6e-93 313.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 PIK49218.1 - 2.2e-37 128.8 0.0 4.1e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 PIK49218.1 - 3.4e-05 24.0 0.1 0.00023 21.3 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 PIK49218.1 - 6.5e-05 22.2 0.0 0.041 13.0 0.0 2.4 3 0 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.12 PIK49218.1 - 0.00011 21.4 0.0 0.00016 20.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 PIK49218.1 - 0.016 14.5 0.0 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK49218.1 - 0.028 14.0 0.0 0.06 12.9 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK49218.1 - 0.038 12.7 0.0 0.059 12.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 PIK49218.1 - 0.048 12.9 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 PIK49218.1 - 0.061 12.6 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Metallophos_C PF14008.6 PIK49218.1 - 0.1 13.5 0.1 2.4 9.1 0.1 2.5 2 0 0 2 2 2 0 Iron/zinc purple acid phosphatase-like protein C ApbA PF02558.16 PIK49218.1 - 0.1 12.3 0.0 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA CCM2_C PF16545.5 PIK49219.1 - 3.7e-24 85.2 0.3 8.2e-24 84.0 0.3 1.5 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PID PF00640.23 PIK49219.1 - 1.4e-06 28.4 1.0 2.5e-06 27.5 1.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ICAP-1_inte_bdg PF10480.9 PIK49219.1 - 0.00021 21.4 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 Beta-1 integrin binding protein CCM2_C PF16545.5 PIK49220.1 - 1.8e-23 83.0 0.7 3.8e-23 81.9 0.2 1.7 2 0 0 2 2 2 1 Cerebral cavernous malformation protein, harmonin-homology PID PF00640.23 PIK49220.1 - 4.1e-06 26.9 1.2 6.6e-06 26.2 1.2 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ICAP-1_inte_bdg PF10480.9 PIK49220.1 - 0.047 13.7 0.4 0.076 13.0 0.4 1.3 1 0 0 1 1 1 0 Beta-1 integrin binding protein PAD PF03068.15 PIK49220.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) DAO PF01266.24 PIK49221.1 - 3.2e-28 99.3 0.0 3.5e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase LcrG PF07216.12 PIK49222.1 - 0.089 12.7 2.6 6.4 6.8 0.1 2.8 2 0 0 2 2 2 0 LcrG protein Methyltrn_RNA_2 PF04013.12 PIK49222.1 - 0.1 12.3 2.1 0.46 10.2 0.1 2.3 2 0 0 2 2 2 0 Putative SAM-dependent RNA methyltransferase DUF3450 PF11932.8 PIK49222.1 - 0.6 9.4 28.1 1.1 8.6 7.0 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 PIK49222.1 - 5.8 6.9 37.4 49 3.9 19.1 3.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PNGaseA PF12222.8 PIK49222.1 - 6.1 5.6 9.2 1.1 8.1 4.9 1.8 2 0 0 2 2 2 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A FUSC PF04632.12 PIK49222.1 - 7.2 5.0 7.3 3.2 6.2 0.1 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family Fibrinogen_C PF00147.18 PIK49223.1 - 6.2e-54 183.1 9.1 8.2e-54 182.7 9.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK49223.1 - 0.00072 19.7 8.8 0.00072 19.7 8.8 2.8 3 0 0 3 3 3 1 EGF domain VCBS PF13517.6 PIK49224.1 - 3.9e-37 126.6 47.3 5.8e-10 39.6 3.5 4.4 1 1 4 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK49224.1 - 3.6e-20 71.8 26.1 0.00036 20.6 0.2 6.7 7 0 0 7 7 7 5 FG-GAP repeat TcdB_toxin_midN PF12256.8 PIK49224.1 - 3.3e-13 49.4 7.6 0.072 12.4 0.0 5.4 2 2 4 6 6 6 5 Insecticide toxin TcdB middle/N-terminal region SH3_5 PF08460.10 PIK49224.1 - 0.00014 21.9 8.1 0.23 11.6 0.1 4.9 5 0 0 5 5 5 2 Bacterial SH3 domain DsbG_N PF18257.1 PIK49224.1 - 0.0066 16.6 0.0 11 6.2 0.0 3.7 4 0 0 4 4 4 1 Disulfide isomerase DsbG N-terminal Dockerin_1 PF00404.18 PIK49224.1 - 0.034 14.3 11.3 68 3.8 0.1 5.2 5 0 0 5 5 5 0 Dockerin type I domain ABC-3 PF00950.17 PIK49224.1 - 0.039 13.5 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 ABC 3 transport family DEFB136 PF17333.2 PIK49224.1 - 0.11 12.5 13.9 43 4.2 0.0 6.1 6 1 0 6 6 6 0 Beta defensin 136 Integrase_H2C2 PF17921.1 PIK49225.1 - 6.8e-09 35.7 0.4 1.1e-08 35.0 0.4 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK49225.1 - 8.1e-06 26.0 0.0 1.5e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 Integrase core domain Nse4-Nse3_bdg PF15412.6 PIK49225.1 - 0.058 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE RVT_1 PF00078.27 PIK49226.1 - 5.1e-08 32.7 0.0 7.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK49226.1 - 0.0015 18.6 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase PvlArgDC PF01862.16 PIK49227.1 - 0.0035 17.2 1.8 0.0046 16.8 1.8 1.2 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) AAA_assoc_2 PF16193.5 PIK49227.1 - 0.031 14.6 0.2 2.9 8.3 0.1 2.5 2 0 0 2 2 2 0 AAA C-terminal domain DUF1704 PF08014.11 PIK49227.1 - 0.047 12.7 2.0 0.061 12.3 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1704) DUF1908 PF08926.11 PIK49227.1 - 0.058 12.5 0.9 0.068 12.3 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) Vicilin_N PF04702.12 PIK49227.1 - 0.22 11.3 5.2 0.32 10.8 5.2 1.2 1 0 0 1 1 1 0 Vicilin N terminal region Peptidase_S46 PF10459.9 PIK49227.1 - 0.57 8.8 3.5 0.67 8.5 3.5 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF3450 PF11932.8 PIK49227.1 - 1.7 7.9 7.5 0.23 10.7 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 PIK49227.1 - 2.2 6.1 6.3 2.5 5.9 6.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lectin_C PF00059.21 PIK49228.1 - 1.1e-11 45.4 3.1 1.2e-11 45.3 3.1 1.0 1 0 0 1 1 1 1 Lectin C-type domain DAO PF01266.24 PIK49229.1 - 3e-36 125.7 0.0 3.6e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK49229.1 - 3.8e-06 27.0 0.1 7.5e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 PIK49229.1 - 4.4e-06 26.0 0.0 0.00035 19.8 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 PIK49229.1 - 4.4e-06 26.2 0.0 0.00099 18.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK49229.1 - 8e-05 21.5 0.0 0.04 12.6 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 PIK49229.1 - 0.00033 20.0 0.0 0.002 17.4 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK49229.1 - 0.00081 18.6 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 PIK49229.1 - 0.0015 18.0 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 PIK49229.1 - 0.0043 16.4 0.1 0.0063 15.8 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 PIK49229.1 - 0.14 12.7 0.0 0.35 11.5 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 PIK49230.1 - 3.5e-28 98.5 35.5 5.2e-24 84.8 20.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK49230.1 - 1.4e-22 80.2 11.4 3.9e-22 78.7 11.4 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter PAS_3 PF08447.12 PIK49231.1 - 1.1e-21 76.9 0.2 1.2e-14 54.4 0.0 2.6 2 1 0 2 2 2 2 PAS fold PAS_11 PF14598.6 PIK49231.1 - 1.1e-16 60.9 0.8 6.6e-10 39.1 0.1 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 PIK49231.1 - 4.4e-11 42.8 0.0 0.00036 20.5 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK49231.1 - 0.0093 16.2 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 PIK49231.1 - 0.0098 16.1 0.0 6.5 7.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold EB PF01683.18 PIK49232.1 - 1.1 9.6 24.5 1.4 9.3 4.7 3.0 1 1 1 2 2 2 0 EB module EGF_2 PF07974.13 PIK49232.1 - 8 6.9 30.7 0.42 11.0 13.4 2.7 3 0 0 3 3 3 0 EGF-like domain Asp_protease_2 PF13650.6 PIK49233.1 - 0.00043 20.9 0.0 0.00093 19.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK49233.1 - 0.0014 19.1 0.0 0.0034 17.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 PIK49233.1 - 0.055 13.3 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease zf-ribbon_3 PF13248.6 PIK49233.1 - 0.27 10.7 5.0 2.4 7.7 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC PF00098.23 PIK49233.1 - 2.1 8.5 13.8 0.44 10.7 0.8 2.8 3 0 0 3 3 3 0 Zinc knuckle ADK_lid PF05191.14 PIK49233.1 - 6.1 6.9 8.2 3.1 7.9 4.4 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid Integrase_H2C2 PF17921.1 PIK49234.1 - 1.2e-16 60.5 0.3 1.9e-16 59.9 0.3 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Dimer_Tnp_hAT PF05699.14 PIK49234.1 - 0.095 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region zf-H2C2 PF09337.10 PIK49234.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger I-set PF07679.16 PIK49235.1 - 3.9e-16 58.9 0.0 6.9e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK49235.1 - 6.8e-15 55.4 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49235.1 - 5.7e-09 36.2 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK49235.1 - 7.2e-08 32.5 0.0 1.5e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK49235.1 - 0.00015 21.9 0.1 0.12 12.5 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin V-set domain Rib_5-P_isom_A PF06026.14 PIK49236.1 - 2.3e-66 222.7 0.0 2.8e-66 222.4 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 PIK49236.1 - 0.0015 18.5 0.2 0.14 12.1 0.2 2.5 2 1 0 2 2 2 1 DeoR C terminal sensor domain Sec63 PF02889.16 PIK49237.1 - 7.8e-171 566.0 6.6 9.9e-90 300.2 0.3 2.6 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.29 PIK49237.1 - 1.3e-45 155.3 0.2 5.8e-22 78.3 0.2 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 PIK49237.1 - 1.4e-34 118.6 2.2 2.6e-34 117.7 0.3 2.6 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 PIK49237.1 - 7.9e-25 87.8 0.0 4.9e-12 46.2 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK49237.1 - 2.5e-10 40.7 0.4 0.00013 22.2 0.0 3.9 3 2 0 3 3 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 PIK49237.1 - 1.5e-08 34.6 0.0 0.0017 18.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 PIK49237.1 - 3e-06 27.5 2.0 0.094 13.0 0.0 3.8 3 0 0 3 3 3 2 AAA domain PhoH PF02562.16 PIK49237.1 - 0.00079 18.9 0.1 0.31 10.5 0.0 3.2 3 0 0 3 3 3 1 PhoH-like protein SWI2_SNF2 PF18766.1 PIK49237.1 - 0.00089 19.0 0.0 0.018 14.7 0.0 2.6 2 0 0 2 2 2 1 SWI2/SNF2 ATPase T2SSE PF00437.20 PIK49237.1 - 0.0014 17.7 0.0 1.2 8.2 0.0 2.8 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF2075 PF09848.9 PIK49237.1 - 0.006 15.9 0.0 0.57 9.3 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 PIK49237.1 - 0.0088 16.4 4.4 6.8 7.0 0.0 4.5 3 2 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.6 PIK49237.1 - 0.043 13.4 0.0 11 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 PIK49237.1 - 0.073 12.9 3.0 1.9 8.2 0.0 3.6 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 PIK49237.1 - 0.088 12.5 0.0 2.6 7.7 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 PIK49237.1 - 0.2 11.1 4.4 18 4.7 0.1 3.9 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_23 PF13476.6 PIK49237.1 - 7.5 7.0 16.4 1 9.8 0.0 4.7 4 1 0 4 4 3 0 AAA domain U-box PF04564.15 PIK49238.1 - 4.2e-20 71.7 0.0 9.3e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain U-box PF04564.15 PIK49239.1 - 0.0018 18.4 0.0 0.0037 17.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-H2C2_2 PF13465.6 PIK49241.1 - 5.6e-09 36.0 0.8 5.6e-09 36.0 0.8 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK49241.1 - 2.8e-08 33.8 2.4 1.3e-05 25.4 0.2 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK49241.1 - 0.00059 20.5 3.9 0.16 12.9 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.15 PIK49241.1 - 0.0019 18.2 3.9 0.0083 16.1 4.1 2.0 1 1 1 2 2 2 1 BED zinc finger zf-RING_2 PF13639.6 PIK49241.1 - 0.0041 17.4 0.4 2.2 8.7 0.0 2.5 2 0 0 2 2 2 1 Ring finger domain GAGA PF09237.11 PIK49241.1 - 0.0042 16.8 2.3 0.83 9.5 0.1 2.4 1 1 1 2 2 2 2 GAGA factor zf-C2H2_8 PF15909.5 PIK49241.1 - 0.0089 16.3 0.7 0.014 15.7 0.7 1.3 1 0 0 1 1 1 1 C2H2-type zinc ribbon Zn-C2H2_12 PF18112.1 PIK49241.1 - 0.014 15.8 1.6 0.081 13.4 0.3 2.3 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 PIK49241.1 - 0.015 15.5 2.5 2.7 8.4 0.1 2.3 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK49241.1 - 0.041 13.6 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 PIK49241.1 - 0.11 12.5 5.1 1 9.4 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 PIK49241.1 - 0.16 12.4 3.8 1.4 9.4 0.4 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Elf1 PF05129.13 PIK49241.1 - 0.16 12.0 5.2 1.7 8.7 0.3 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2HE PF16278.5 PIK49241.1 - 0.17 12.4 3.8 0.2 12.1 0.5 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger UBZ_FAAP20 PF15750.5 PIK49241.1 - 0.26 11.2 1.3 9.7 6.2 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Prok-RING_4 PF14447.6 PIK49241.1 - 0.32 10.9 4.8 4.2 7.3 4.8 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK49241.1 - 0.33 10.9 3.6 1.2 9.2 3.6 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-H2C2_2 PF13465.6 PIK49242.1 - 6.5e-20 70.6 29.7 3e-08 33.7 0.8 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK49242.1 - 2.3e-19 68.7 31.9 3.6e-05 24.0 1.5 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK49242.1 - 5.7e-11 42.3 29.4 0.0057 17.4 2.3 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger GAGA PF09237.11 PIK49242.1 - 5.2e-06 26.2 10.8 0.0019 17.9 0.7 3.5 1 1 1 3 3 3 3 GAGA factor zf-met PF12874.7 PIK49242.1 - 3.2e-05 24.1 20.1 0.11 12.9 0.4 4.7 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK49242.1 - 0.00096 19.4 14.1 0.52 10.7 0.1 4.7 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK49242.1 - 0.0011 19.2 15.1 0.023 15.0 3.7 2.6 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 PIK49242.1 - 0.003 17.3 17.4 0.53 10.1 0.0 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 PIK49242.1 - 0.0074 16.6 14.9 3.5 8.0 10.9 4.0 1 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 PIK49242.1 - 0.012 15.9 17.0 0.21 11.9 2.4 3.7 2 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.19 PIK49242.1 - 0.078 13.0 4.8 0.51 10.4 3.9 2.6 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TRAF6_Z2 PF18048.1 PIK49242.1 - 0.11 12.6 0.4 0.11 12.6 0.4 3.8 4 0 0 4 4 3 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_9 PF16293.5 PIK49242.1 - 0.13 12.1 5.4 1.4 8.8 0.2 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 PIK49242.1 - 0.16 12.4 0.1 0.16 12.4 0.1 3.6 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain BolA PF01722.18 PIK49242.1 - 0.21 11.9 3.1 18 5.7 0.4 3.3 1 1 3 4 4 4 0 BolA-like protein zf-C3HC4_2 PF13923.6 PIK49242.1 - 0.28 11.1 7.2 32 4.5 0.0 4.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK49242.1 - 0.49 10.8 10.6 11 6.5 0.1 4.0 2 1 1 3 3 3 0 Ring finger domain zinc_ribbon_15 PF17032.5 PIK49242.1 - 0.69 10.7 6.9 13 6.6 0.3 2.8 1 1 1 2 2 2 0 zinc-ribbon family zf-Sec23_Sec24 PF04810.15 PIK49242.1 - 0.77 9.9 10.6 3.8 7.6 0.1 4.0 4 0 0 4 4 4 0 Sec23/Sec24 zinc finger zf-BED PF02892.15 PIK49242.1 - 1.2 9.2 20.1 4.5 7.4 10.2 3.9 1 1 1 2 2 2 0 BED zinc finger C1_4 PF07975.12 PIK49242.1 - 2 8.7 10.7 1.4 9.2 1.0 2.8 2 0 0 2 2 2 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 PIK49242.1 - 2.4 8.2 9.4 11 6.1 3.6 3.3 2 1 0 2 2 2 0 zinc-ribbons PHD PF00628.29 PIK49242.1 - 8.7 6.3 10.0 31 4.6 5.3 2.8 1 1 1 2 2 2 0 PHD-finger Elf1 PF05129.13 PIK49242.1 - 9.8 6.3 13.1 1.1 9.3 1.5 3.3 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like EGF PF00008.27 PIK49243.1 - 2.7e-170 551.9 625.8 2.6e-09 37.2 5.4 42.6 42 0 0 42 42 42 41 EGF-like domain hEGF PF12661.7 PIK49243.1 - 1.1e-67 222.6 522.9 2.9e-05 24.5 5.7 44.1 43 0 0 43 43 43 36 Human growth factor-like EGF EGF_2 PF07974.13 PIK49243.1 - 2.8e-47 158.7 709.1 0.0065 16.8 10.6 42.2 42 0 0 42 42 42 39 EGF-like domain zf-H2C2_2 PF13465.6 PIK49244.1 - 5e-33 112.0 33.0 4.3e-08 33.2 1.2 6.4 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK49244.1 - 3.5e-30 102.7 36.5 7e-07 29.4 1.6 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK49244.1 - 1.1e-21 75.6 32.9 0.00014 22.4 0.9 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK49244.1 - 4.6e-13 49.1 12.5 0.0094 16.2 0.1 5.0 5 0 0 5 5 4 4 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK49244.1 - 7.3e-11 41.9 24.9 7e-05 22.8 0.9 5.3 4 1 1 5 5 5 4 BED zinc finger zf-met PF12874.7 PIK49244.1 - 2e-09 37.5 26.5 0.016 15.6 0.2 5.5 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK49244.1 - 3.9e-09 36.3 28.6 3.3e-05 23.7 0.8 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK49244.1 - 2e-08 33.8 35.0 0.025 14.3 1.4 6.3 5 2 0 5 5 5 4 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 PIK49244.1 - 9.1e-07 29.2 17.5 0.23 11.8 0.7 5.1 1 1 4 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 PIK49244.1 - 1.1e-06 28.8 13.2 0.00056 20.2 0.5 3.4 1 1 2 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 PIK49244.1 - 0.00017 21.4 10.7 0.034 14.0 0.0 4.3 2 1 3 5 5 4 2 GAGA factor zf-C2H2_11 PF16622.5 PIK49244.1 - 0.0035 17.1 27.8 0.033 14.0 1.0 5.4 5 0 0 5 5 5 1 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 PIK49244.1 - 0.03 14.2 7.7 18 5.3 0.1 4.7 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) DZR PF12773.7 PIK49244.1 - 0.045 13.8 1.0 0.045 13.8 1.0 2.6 2 1 0 2 2 2 0 Double zinc ribbon FKBP_N_2 PF18023.1 PIK49244.1 - 0.066 13.3 0.0 3.8 7.6 0.0 2.9 3 0 0 3 3 3 0 BDBT FKBP like N-terminal zf-C2H2_3rep PF18868.1 PIK49244.1 - 0.079 13.6 7.4 20 5.8 6.7 3.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK49244.1 - 0.093 13.0 17.8 0.13 12.6 3.8 2.8 2 1 1 3 3 2 0 C2H2-type zinc ribbon BolA PF01722.18 PIK49244.1 - 0.1 12.9 3.1 12 6.2 1.0 3.1 1 1 2 3 3 3 0 BolA-like protein zf-MYST PF17772.1 PIK49244.1 - 0.15 11.7 5.6 22 4.8 0.1 4.3 3 1 2 5 5 5 0 MYST family zinc finger domain C1_2 PF03107.16 PIK49244.1 - 0.16 12.3 18.1 1.8e+04 -4.3 18.1 4.7 1 1 0 1 1 0 0 C1 domain zinc_ribbon_15 PF17032.5 PIK49244.1 - 0.18 12.6 9.1 5.5 7.8 0.9 3.0 1 1 2 3 3 3 0 zinc-ribbon family C1_4 PF07975.12 PIK49244.1 - 0.44 10.8 11.4 0.65 10.3 1.8 3.1 2 1 1 3 3 3 0 TFIIH C1-like domain Zn_ribbon_SprT PF17283.2 PIK49244.1 - 1.1 9.3 19.5 0.15 12.0 3.5 3.9 3 1 0 3 3 3 0 SprT-like zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 PIK49244.1 - 1.9 8.6 14.9 2.1 8.4 1.4 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-C2HE PF16278.5 PIK49244.1 - 2.7 8.5 19.6 1.8 9.1 0.4 4.8 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-CHY PF05495.12 PIK49244.1 - 3.6 8.1 16.6 1.4 9.4 7.2 3.2 1 1 3 4 4 4 0 CHY zinc finger DUF2225 PF09986.9 PIK49244.1 - 4.4 7.0 6.7 51 3.5 0.3 3.7 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn-ribbon_8 PF09723.10 PIK49244.1 - 4.6 7.4 12.6 9.6 6.4 2.3 3.9 3 2 1 4 4 4 0 Zinc ribbon domain CUB PF00431.20 PIK49245.1 - 6.7e-16 58.6 0.0 8.1e-10 39.0 0.1 2.4 2 0 0 2 2 2 2 CUB domain PAN_1 PF00024.26 PIK49245.1 - 2e-07 30.9 0.1 2e-07 30.9 0.1 2.3 2 0 0 2 2 2 1 PAN domain PAN_4 PF14295.6 PIK49245.1 - 0.0072 16.2 2.2 0.018 14.9 2.2 1.6 1 0 0 1 1 1 1 PAN domain Pneumo_att_G PF05539.11 PIK49245.1 - 0.03 13.9 36.6 0.039 13.6 36.6 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G PAN_3 PF08277.12 PIK49245.1 - 0.23 11.3 1.7 1.1 9.2 1.7 2.2 1 0 0 1 1 1 0 PAN-like domain GREB1 PF15782.5 PIK49245.1 - 5.1 4.1 7.3 6.3 3.8 7.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tetraspanin PF00335.20 PIK49247.1 - 6.3e-46 156.9 5.6 7.4e-46 156.7 5.6 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2206 PF09971.9 PIK49247.1 - 0.001 17.9 6.0 0.0015 17.4 6.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2206) TadE PF07811.12 PIK49247.1 - 0.036 14.3 0.3 0.036 14.3 0.3 2.6 3 0 0 3 3 3 0 TadE-like protein DUF2207 PF09972.9 PIK49247.1 - 0.17 10.6 2.5 0.26 10.0 2.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SUR7 PF06687.12 PIK49247.1 - 0.27 10.8 4.8 0.51 9.9 4.8 1.6 1 0 0 1 1 1 0 SUR7/PalI family MARVEL PF01284.23 PIK49247.1 - 0.38 10.8 9.1 0.97 9.5 0.6 2.4 1 1 1 2 2 2 0 Membrane-associating domain ASFV_J13L PF05568.11 PIK49247.1 - 0.77 9.5 2.3 0.85 9.3 1.6 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein EIIC-GAT PF03611.14 PIK49247.1 - 1.4 8.0 12.9 0.28 10.2 9.4 1.7 2 1 0 2 2 2 0 PTS system sugar-specific permease component NAD4L PF06235.11 PIK49247.1 - 2.3 8.3 13.8 1.4 9.0 10.4 2.2 2 1 0 2 2 2 0 NADH dehydrogenase subunit 4L (NAD4L) HMG_box PF00505.19 PIK49249.1 - 7.1e-15 55.2 0.3 1.5e-14 54.1 0.3 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK49249.1 - 2.4e-11 44.0 0.2 5.6e-11 42.9 0.2 1.6 1 0 0 1 1 1 1 HMG-box domain zf-C2H2_jaz PF12171.8 PIK49249.1 - 0.00025 21.3 4.1 0.0003 21.0 2.9 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Protamine_like PF06382.11 PIK49249.1 - 0.0053 17.0 0.4 0.0097 16.1 0.4 1.5 1 1 0 1 1 1 1 Protamine and protamine like zf-met PF12874.7 PIK49249.1 - 0.0059 17.0 3.5 0.012 15.9 3.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK49249.1 - 0.079 13.3 0.8 0.16 12.3 0.8 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 PIK49249.1 - 0.14 12.0 1.6 0.28 11.0 1.1 1.7 2 0 0 2 2 2 0 U1 zinc finger Tricorn_PDZ PF14685.6 PIK49250.1 - 0.00089 19.2 0.1 0.022 14.7 0.0 3.0 3 0 0 3 3 3 1 Tricorn protease PDZ domain PDZ_2 PF13180.6 PIK49250.1 - 0.018 15.3 0.0 0.074 13.4 0.0 2.0 2 0 0 2 2 2 0 PDZ domain PDZ_6 PF17820.1 PIK49250.1 - 0.056 13.3 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 PDZ domain Draxin PF15550.6 PIK49251.1 - 6.1 6.6 8.5 9.9 5.9 8.5 1.4 1 0 0 1 1 1 0 Draxin FA_desaturase PF00487.24 PIK49252.1 - 1.7e-11 44.5 1.5 1.8e-11 44.3 1.5 1.0 1 0 0 1 1 1 1 Fatty acid desaturase Hema_stalk PF08720.10 PIK49253.1 - 0.0076 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Influenza C hemagglutinin stalk Lentiviral_Tat PF02998.14 PIK49253.1 - 0.037 14.1 0.2 0.12 12.4 0.2 1.8 1 0 0 1 1 1 0 Lentiviral Tat protein TGS PF02824.21 PIK49253.1 - 0.15 12.1 0.0 2.5 8.2 0.0 2.3 1 1 1 2 2 2 0 TGS domain zinc_ribbon_2 PF13240.6 PIK49254.1 - 0.00038 20.1 4.4 0.00038 20.1 4.4 2.7 3 0 0 3 3 3 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 PIK49254.1 - 0.00054 19.3 1.3 0.0061 15.9 1.0 2.7 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 PIK49254.1 - 0.0018 18.3 0.6 0.0018 18.3 0.6 2.2 2 0 0 2 2 2 1 Double zinc ribbon PDZ PF00595.24 PIK49254.1 - 0.0026 18.1 0.2 0.033 14.5 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK49254.1 - 0.053 13.4 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 PDZ domain DAN PF03045.15 PIK49254.1 - 4.9 7.2 9.0 9.1 6.4 0.0 3.5 4 1 1 5 5 5 0 DAN domain Ribosomal_L28e PF01778.17 PIK49255.1 - 2.9e-37 127.9 2.3 1.3e-36 125.8 0.4 2.2 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 PIK49255.1 - 6.9e-28 97.2 20.4 6.9e-28 97.2 20.4 2.0 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 PIK49255.1 - 0.0004 19.8 12.1 0.00049 19.6 12.1 1.1 1 0 0 1 1 1 1 BUD22 PC4 PF02229.16 PIK49255.1 - 0.037 13.7 0.0 0.098 12.3 0.0 1.7 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Nop14 PF04147.12 PIK49255.1 - 0.068 11.4 16.6 0.083 11.1 16.6 1.1 1 0 0 1 1 1 0 Nop14-like family AbiEi_4 PF13338.6 PIK49255.1 - 0.13 12.4 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Leu_zip PF15294.6 PIK49256.1 - 9.4e-57 192.6 1.6 1.1e-56 192.4 1.6 1.0 1 0 0 1 1 1 1 Leucine zipper GEMIN8 PF15348.6 PIK49256.1 - 0.093 13.0 0.1 0.1 12.9 0.1 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 PIP49_C PF12260.8 PIK49257.1 - 8.4e-43 146.2 0.5 1.5e-42 145.4 0.5 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 PIK49257.1 - 2.1e-12 47.2 0.2 5.3e-12 45.9 0.2 1.7 1 0 0 1 1 1 1 N-term cysteine-rich ER, FAM69 MFS_1 PF07690.16 PIK49258.1 - 0.13 11.2 3.8 0.27 10.1 1.3 2.0 1 1 1 2 2 2 0 Major Facilitator Superfamily Aa_trans PF01490.18 PIK49259.1 - 1.6e-44 152.3 11.4 1.6e-43 149.0 11.4 1.9 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Epiglycanin_C PF14654.6 PIK49259.1 - 0.063 13.4 0.6 3.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region Cation_ATPase_C PF00689.21 PIK49260.1 - 1.8e-06 27.8 6.5 3e-06 27.1 6.5 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Coa1 PF08695.10 PIK49260.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 E1-E2_ATPase PF00122.20 PIK49261.1 - 5.5e-33 114.0 0.1 5.5e-33 114.0 0.1 1.6 2 0 0 2 2 2 1 E1-E2 ATPase P5-ATPase PF12409.8 PIK49261.1 - 4.6e-22 78.5 1.0 1.4e-21 76.9 1.0 1.8 1 1 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase PF13246.6 PIK49261.1 - 4.8e-07 29.8 0.0 9.4e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 PIK49261.1 - 2.2e-06 28.1 0.0 1.7e-05 25.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 PIK49261.1 - 1.6e-05 24.5 0.0 4.2e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus TMEM51 PF15345.6 PIK49261.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4244 PF14029.6 PIK49261.1 - 0.19 11.2 1.0 0.38 10.2 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Cyclin_N PF00134.23 PIK49262.1 - 3.1e-12 46.4 1.7 1.1e-08 34.9 0.2 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK49262.1 - 2e-05 24.7 0.5 0.00043 20.4 0.1 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 PIK49262.1 - 0.00029 21.2 0.0 0.0007 19.9 0.0 1.8 1 0 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.19 PIK49262.1 - 0.00055 19.9 0.2 1.1 9.4 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Ribosomal_L20 PF00453.18 PIK49263.1 - 3e-36 123.7 2.0 4.3e-36 123.3 2.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L20 PI3_PI4_kinase PF00454.27 PIK49264.1 - 2.6e-55 188.0 1.1 2.6e-55 188.0 1.1 2.9 3 1 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 PIK49264.1 - 1e-52 178.2 2.6 2e-52 177.3 2.6 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.16 PIK49264.1 - 3.9e-28 97.0 0.0 1e-27 95.7 0.0 1.8 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 PIK49264.1 - 3.9e-25 88.1 2.3 5.9e-25 87.5 1.0 2.0 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 PIK49264.1 - 2.3e-22 79.4 0.0 5.5e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 PIK49264.1 - 0.025 13.9 0.1 0.059 12.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) fn3 PF00041.21 PIK49265.1 - 7e-24 84.0 4.9 1.9e-12 47.4 0.7 2.4 2 0 0 2 2 2 2 Fibronectin type III domain EphA2_TM PF14575.6 PIK49265.1 - 7e-17 62.1 0.0 1.8e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.5 PIK49265.1 - 1.3e-08 35.3 1.1 0.0017 18.9 0.0 2.6 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Pkinase_Tyr PF07714.17 PIK49265.1 - 4.8e-05 22.8 0.0 7.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LAX PF15681.5 PIK49265.1 - 0.0073 15.2 0.2 0.015 14.1 0.2 1.4 1 0 0 1 1 1 1 Lymphocyte activation family X DUF2369 PF10179.9 PIK49265.1 - 0.019 15.4 0.1 1.6 9.1 0.1 2.8 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) PTP_tm PF18861.1 PIK49265.1 - 0.054 13.5 1.0 0.12 12.4 1.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Anoctamin PF04547.12 PIK49265.1 - 0.061 12.1 0.0 0.077 11.8 0.0 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel Insulin_TMD PF17870.1 PIK49265.1 - 0.1 12.7 0.6 0.23 11.5 0.6 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment SusE PF14292.6 PIK49265.1 - 0.13 12.5 0.8 1.8 8.9 0.2 2.3 2 0 0 2 2 2 0 SusE outer membrane protein RIFIN PF02009.16 PIK49265.1 - 0.14 12.0 0.3 0.58 10.0 0.8 1.7 2 0 0 2 2 2 0 Rifin Stevor PF17410.2 PIK49265.1 - 0.18 11.3 0.4 0.32 10.5 0.4 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 PIK49265.1 - 0.2 10.4 1.8 0.24 10.1 0.9 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Syndecan PF01034.20 PIK49265.1 - 0.24 11.3 0.5 0.51 10.3 0.5 1.5 1 0 0 1 1 1 0 Syndecan domain Cadherin_C_2 PF16492.5 PIK49265.1 - 0.3 11.8 0.8 1.3 9.8 0.0 2.3 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal FeoB_associated PF12669.7 PIK49265.1 - 1.9 8.9 4.1 2.4 8.6 3.2 1.6 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Pkinase_Tyr PF07714.17 PIK49266.1 - 6.1e-52 176.5 0.0 8.1e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49266.1 - 3.8e-21 75.6 0.0 5.1e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 PIK49266.1 - 2.4e-19 69.5 0.1 3.7e-19 68.9 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK49266.1 - 4.6e-17 61.9 0.0 7.8e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 PIK49266.1 - 0.081 12.2 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like MIIP PF15734.5 PIK49267.1 - 4.7e-62 210.5 22.1 1.9e-61 208.5 22.1 1.8 1 1 0 1 1 1 1 Migration and invasion-inhibitory SCAN PF02023.17 PIK49268.1 - 0.00074 19.3 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 SCAN domain bZIP_2 PF07716.15 PIK49268.1 - 1.3 9.2 5.3 4 7.6 0.0 2.3 2 0 0 2 2 2 0 Basic region leucine zipper Sulfotransfer_2 PF03567.14 PIK49269.1 - 1.8e-31 110.0 0.5 3.3e-31 109.1 0.5 1.4 1 0 0 1 1 1 1 Sulfotransferase family L31 PF09784.9 PIK49269.1 - 0.026 15.0 2.1 2.2 8.8 0.4 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 YvfG PF09628.10 PIK49269.1 - 0.048 14.0 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 YvfG protein GFO_IDH_MocA PF01408.22 PIK49270.1 - 1.8e-19 70.7 0.0 3.9e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK49270.1 - 0.00045 20.2 0.0 0.00076 19.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain RVT_1 PF00078.27 PIK49271.1 - 0.04 13.4 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L29 PF00831.23 PIK49272.1 - 0.00085 19.3 0.8 1.3 9.0 0.4 2.8 2 0 0 2 2 2 2 Ribosomal L29 protein GAS PF13851.6 PIK49273.1 - 1.6e-08 34.2 42.6 1.8e-07 30.7 27.4 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK49273.1 - 1.1e-05 25.4 50.3 0.00045 20.1 27.4 2.0 1 1 1 2 2 2 2 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK49273.1 - 8.7e-05 23.1 52.2 0.0039 17.7 24.8 2.7 1 1 1 2 2 2 2 Apg6 coiled-coil region DUF4472 PF14739.6 PIK49273.1 - 0.0017 19.0 35.6 0.036 14.8 13.7 3.4 1 1 2 3 3 3 1 Domain of unknown function (DUF4472) HIP1_clath_bdg PF16515.5 PIK49273.1 - 0.0023 18.5 47.3 0.39 11.3 12.6 3.0 1 1 2 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 KASH_CCD PF14662.6 PIK49273.1 - 0.0053 16.6 45.3 0.029 14.2 15.3 2.5 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH Cep57_MT_bd PF06657.13 PIK49273.1 - 0.0061 17.0 29.1 0.17 12.3 5.7 4.1 1 1 4 5 5 5 4 Centrosome microtubule-binding domain of Cep57 SOGA PF11365.8 PIK49273.1 - 0.0068 17.5 34.5 0.95 10.6 20.2 3.7 1 1 1 3 3 3 2 Protein SOGA DUF4600 PF15372.6 PIK49273.1 - 0.017 15.6 31.6 0.89 10.0 11.3 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) Lebercilin PF15619.6 PIK49273.1 - 0.051 13.2 44.4 1.1 8.9 41.4 3.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF4172 PF13776.6 PIK49273.1 - 0.078 13.3 13.3 0.87 10.0 0.5 3.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4172) T2SSN PF01203.19 PIK49273.1 - 0.084 13.1 10.1 2.7 8.1 3.6 2.7 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein N FPP PF05911.11 PIK49273.1 - 0.12 10.6 37.4 0.034 12.3 24.3 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF3584 PF12128.8 PIK49273.1 - 0.16 9.5 35.9 0.19 9.2 35.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 PIK49273.1 - 0.19 12.1 40.8 0.41 11.1 40.8 1.5 1 1 0 1 1 1 0 Fez1 DUF1664 PF07889.12 PIK49273.1 - 0.22 11.5 20.1 1.9 8.6 8.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4376 PF14301.6 PIK49273.1 - 0.26 11.7 10.0 3.2 8.2 1.3 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4376) Frankia_peptide PF14407.6 PIK49273.1 - 0.32 11.0 7.4 5.4 7.1 0.3 3.6 1 1 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. ATG16 PF08614.11 PIK49273.1 - 0.35 11.1 51.0 0.18 12.0 34.3 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Nsp1_C PF05064.13 PIK49273.1 - 0.38 10.6 31.7 4.3 7.2 7.9 3.1 1 1 2 3 3 3 0 Nsp1-like C-terminal region FlgN PF05130.12 PIK49273.1 - 0.56 10.7 35.0 2.7 8.5 14.3 2.8 1 1 1 2 2 2 0 FlgN protein DUF3450 PF11932.8 PIK49273.1 - 0.57 9.4 35.5 1.6 8.0 19.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) SKA2 PF16740.5 PIK49273.1 - 0.7 9.7 27.1 2.1 8.2 6.1 3.3 1 1 3 4 4 4 0 Spindle and kinetochore-associated protein 2 CREPT PF16566.5 PIK49273.1 - 0.8 9.9 31.4 0.66 10.1 14.3 2.5 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour JIP_LZII PF16471.5 PIK49273.1 - 0.96 9.7 41.2 0.79 9.9 7.4 4.4 1 1 3 5 5 5 0 JNK-interacting protein leucine zipper II DUF4726 PF15855.5 PIK49273.1 - 0.99 9.7 15.3 2.6 8.3 2.6 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4726) TACC_C PF05010.14 PIK49273.1 - 1 9.1 33.9 2.7 7.7 33.6 1.7 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPD52 PF04201.15 PIK49273.1 - 1.3 8.6 34.8 1 9.0 9.4 3.3 1 1 2 3 3 3 0 Tumour protein D52 family PI3K_P85_iSH2 PF16454.5 PIK49273.1 - 1.5 8.4 36.0 3.2 7.3 6.0 4.0 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FmiP_Thoc5 PF09766.9 PIK49273.1 - 1.5 8.1 40.8 8.7 5.5 23.1 2.3 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 PilA4 PF18682.1 PIK49273.1 - 1.7 9.1 13.4 13 6.2 0.6 4.3 1 1 2 4 4 4 0 Pilin A4 ZapB PF06005.12 PIK49273.1 - 1.8 9.1 49.6 1.9 9.0 8.0 4.2 1 1 5 6 6 6 0 Cell division protein ZapB CALCOCO1 PF07888.11 PIK49273.1 - 2 7.2 45.8 3.6 6.3 45.7 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.22 PIK49273.1 - 2.1 8.6 33.4 2.1 8.6 16.2 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Jnk-SapK_ap_N PF09744.9 PIK49273.1 - 2.2 8.5 46.3 53 4.0 16.7 3.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Sipho_Gp157 PF05565.11 PIK49273.1 - 2.5 8.1 32.1 1.9 8.5 4.5 3.8 1 1 3 4 4 4 0 Siphovirus Gp157 bZIP_1 PF00170.21 PIK49273.1 - 3.1 8.0 40.4 0.15 12.2 5.0 4.8 2 1 4 6 6 6 0 bZIP transcription factor Oberon_cc PF16312.5 PIK49273.1 - 3.2 7.7 42.8 64 3.5 6.3 5.3 1 1 1 2 2 1 0 Coiled-coil region of Oberon Nnf1 PF03980.14 PIK49273.1 - 3.6 8.0 42.4 3.4 8.1 2.9 5.0 1 1 3 5 5 5 0 Nnf1 DUF150_C PF17384.2 PIK49273.1 - 3.8 7.7 18.1 6.7 6.9 0.6 4.6 1 1 3 4 4 4 0 RimP C-terminal SH3 domain Uso1_p115_C PF04871.13 PIK49273.1 - 3.9 7.9 43.5 4.7 7.6 18.3 2.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region ADIP PF11559.8 PIK49273.1 - 5.7 7.0 45.3 5.9 7.0 16.0 2.8 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 PIK49273.1 - 5.7 5.7 40.4 9.2 5.0 26.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 PIK49273.1 - 6.1 7.1 39.7 0.88 9.8 13.0 3.3 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.12 PIK49273.1 - 9.9 4.6 13.2 12 4.3 13.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family 7tm_1 PF00001.21 PIK49274.1 - 4.8e-16 58.9 6.7 6.3e-16 58.5 6.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK49274.1 - 5e-06 26.1 3.6 8.7e-06 25.3 3.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx EI24 PF07264.11 PIK49274.1 - 0.0018 18.6 4.1 0.0025 18.1 4.1 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) PRT_C PF08372.10 PIK49274.1 - 0.014 15.2 0.2 0.022 14.5 0.2 1.4 1 1 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal 7TM_GPCR_Srv PF10323.9 PIK49274.1 - 0.062 12.6 5.6 0.087 12.2 5.6 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 PIK49275.1 - 6.8e-59 199.3 17.2 8.5e-59 199.0 17.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK49275.1 - 1.8e-22 80.0 16.0 2.5e-22 79.5 16.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK49275.1 - 5.4e-08 32.8 12.9 5.4e-08 32.8 12.9 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK49275.1 - 2.6e-06 27.4 18.3 2.5e-05 24.1 18.3 2.5 1 1 0 1 1 1 1 Olfactory receptor DUF5337 PF17272.2 PIK49275.1 - 0.24 11.2 1.4 3.1 7.7 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5337) DUF3087 PF11286.8 PIK49275.1 - 0.69 9.4 4.7 3.6 7.0 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3087) PRT_C PF08372.10 PIK49275.1 - 1.3 8.7 6.1 0.078 12.7 0.4 2.1 2 1 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal MMU163 PF17119.5 PIK49276.1 - 0.0097 15.1 0.1 4 6.5 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial protein up-regulated during meiosis GAS PF13851.6 PIK49277.1 - 2.2e-07 30.4 87.4 0.0069 15.8 21.5 3.4 1 1 2 3 3 3 3 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK49277.1 - 8.1e-07 29.1 108.0 0.00025 21.0 38.3 3.0 1 1 2 3 3 3 3 Ezrin/radixin/moesin family KASH_CCD PF14662.6 PIK49277.1 - 0.00036 20.4 90.6 0.12 12.2 20.4 4.5 1 1 3 4 4 4 3 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 PIK49277.1 - 0.002 18.6 105.5 0.039 14.5 37.7 4.4 1 1 2 3 3 3 2 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 PIK49277.1 - 0.01 16.4 93.2 0.3 11.7 21.9 5.9 2 2 4 6 6 6 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1664 PF07889.12 PIK49277.1 - 0.04 14.0 43.9 0.056 13.5 5.8 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) T2SSN PF01203.19 PIK49277.1 - 0.21 11.8 16.3 1.6 8.9 3.2 3.7 1 1 1 3 3 3 0 Type II secretion system (T2SS), protein N DUF4472 PF14739.6 PIK49277.1 - 0.22 12.3 76.7 0.33 11.7 14.4 5.3 1 1 5 6 6 6 0 Domain of unknown function (DUF4472) Fez1 PF06818.15 PIK49277.1 - 1.2 9.5 82.8 0.95 9.9 29.5 3.3 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 PIK49277.1 - 1.8 7.4 85.4 2.7 6.8 30.5 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Cep57_MT_bd PF06657.13 PIK49277.1 - 3.3 8.2 58.4 0.41 11.1 5.6 6.6 1 1 7 8 8 8 0 Centrosome microtubule-binding domain of Cep57 DUF4726 PF15855.5 PIK49277.1 - 3.8 7.8 24.8 12 6.2 0.7 5.0 1 1 1 4 4 4 0 Domain of unknown function (DUF4726) Lebercilin PF15619.6 PIK49277.1 - 6.1 6.5 93.8 26 4.4 21.1 5.1 1 1 3 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease SIR2 PF02146.17 PIK49278.1 - 3.6e-51 173.6 0.0 5.2e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 PIK49278.1 - 0.12 12.2 0.0 0.35 10.6 0.0 1.8 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Cytomega_TRL10 PF06084.11 PIK49279.1 - 7 6.7 8.9 1.1 9.3 3.4 2.4 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein Pkinase PF00069.25 PIK49280.1 - 1.9e-64 217.6 0.0 2.6e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49280.1 - 1.5e-42 145.7 0.0 2.2e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK49280.1 - 1.2e-05 24.3 0.5 2.6e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 PIK49280.1 - 0.00016 21.1 0.0 0.012 14.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 PIK49280.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK49280.1 - 0.29 10.0 3.9 1.2 8.0 0.0 2.5 3 0 0 3 3 3 0 Haspin like kinase domain bZIP_1 PF00170.21 PIK49281.1 - 9.8e-10 38.4 15.5 9.8e-09 35.2 15.6 2.2 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK49281.1 - 2.3e-07 30.8 18.5 5.8e-05 23.1 18.3 2.4 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.17 PIK49281.1 - 1.3e-06 28.9 12.4 2.4e-06 28.0 12.4 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor NRBF2 PF08961.10 PIK49281.1 - 6.3e-06 25.9 4.6 7e-06 25.8 4.6 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 PIK49281.1 - 0.0034 18.0 3.9 0.0034 18.0 3.9 1.6 1 1 0 1 1 1 1 Initiation control protein YabA Csm1_N PF18504.1 PIK49281.1 - 0.009 16.3 4.7 0.018 15.4 4.3 1.8 1 1 0 1 1 1 1 Csm1 N-terminal domain TSC22 PF01166.18 PIK49281.1 - 0.03 14.6 5.4 0.76 10.1 0.7 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family Scaffolding_pro PF11418.8 PIK49281.1 - 0.041 14.4 1.0 0.064 13.8 1.0 1.4 1 0 0 1 1 1 0 Phi29 scaffolding protein DivIC PF04977.15 PIK49281.1 - 0.079 12.7 5.6 0.062 13.1 3.9 1.7 1 1 1 2 2 2 0 Septum formation initiator DUF724 PF05266.14 PIK49281.1 - 0.18 11.6 5.8 0.24 11.2 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Herpes_BLRF2 PF05812.12 PIK49281.1 - 0.22 11.7 7.1 0.15 12.2 0.8 2.5 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein ZapB PF06005.12 PIK49281.1 - 0.23 11.9 14.3 0.34 11.4 11.8 2.3 1 1 1 2 2 2 0 Cell division protein ZapB Mak16 PF04874.14 PIK49281.1 - 0.46 11.1 8.3 0.69 10.5 8.3 1.3 1 0 0 1 1 1 0 Mak16 protein C-terminal region CHASE3 PF05227.13 PIK49281.1 - 2.7 7.9 11.4 0.2 11.6 3.0 2.6 1 1 2 3 3 3 0 CHASE3 domain PIG-L PF02585.17 PIK49282.1 - 2.7e-20 73.3 0.0 4e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase CLIP1_ZNF PF16641.5 PIK49282.1 - 0.093 12.6 0.2 0.36 10.8 0.2 2.0 1 0 0 1 1 1 0 CLIP1 zinc knuckle Neur_chan_LBD PF02931.23 PIK49283.1 - 1.2e-54 185.0 2.5 1.4e-54 184.8 2.5 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DCD PF06559.11 PIK49283.1 - 0.16 10.7 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) TPR_17 PF13431.6 PIK49284.1 - 6.6e-19 66.9 3.8 0.0024 18.1 0.1 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49284.1 - 3.9e-17 61.3 6.5 1.8e-05 24.3 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49284.1 - 1e-15 58.0 3.6 9.9e-08 32.4 0.9 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49284.1 - 1.2e-15 56.3 7.3 0.00014 21.7 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49284.1 - 5.2e-15 54.3 2.2 0.024 14.8 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 PIK49284.1 - 6.3e-14 51.4 4.6 5.1e-05 22.9 0.7 5.5 3 1 3 6 6 6 3 TPR repeat TPR_16 PF13432.6 PIK49284.1 - 6.3e-13 49.1 16.5 3.1e-05 24.5 5.0 3.1 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK49284.1 - 9.2e-13 48.3 10.6 2.6e-06 27.6 1.5 3.4 2 2 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK49284.1 - 6.9e-12 45.1 3.7 0.00014 22.4 0.2 4.3 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 PIK49284.1 - 6.7e-08 32.2 11.5 0.011 15.6 0.3 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat EST1_DNA_bind PF10373.9 PIK49284.1 - 3.1e-07 30.2 0.1 0.0019 17.7 0.0 2.2 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain TPR_7 PF13176.6 PIK49284.1 - 5.4e-07 29.2 2.4 0.67 10.1 0.1 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat Glyco_hyd_65N_2 PF14498.6 PIK49284.1 - 2.1e-05 24.5 1.0 0.00026 20.9 0.2 2.0 1 1 1 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain TPR_9 PF13371.6 PIK49284.1 - 2.8e-05 24.2 1.3 0.011 15.8 0.8 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK49284.1 - 0.00045 19.5 1.4 0.0017 17.6 0.9 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 PIK49284.1 - 0.00088 19.7 0.8 0.78 10.5 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK49284.1 - 0.0015 18.8 1.8 0.14 12.4 0.7 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 PIK49284.1 - 0.0025 18.1 2.6 0.44 10.9 0.3 3.6 2 1 2 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 PIK49284.1 - 0.014 15.8 1.7 0.028 14.8 0.5 1.9 1 1 0 2 2 2 0 Bacterial transcriptional activator domain HrpB1_HrpK PF09613.10 PIK49284.1 - 0.077 12.6 0.1 0.47 10.1 0.0 1.9 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPPII_N PF12583.8 PIK49284.1 - 0.34 11.5 1.2 3.9 8.1 0.0 2.8 2 1 2 4 4 4 0 Tripeptidyl peptidase II N terminal DUF1736 PF08409.11 PIK49285.1 - 2.4e-31 107.5 1.8 6e-31 106.3 1.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_1 PF00515.28 PIK49285.1 - 1.1e-17 63.0 3.0 1.6e-07 30.8 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49285.1 - 2.2e-16 58.6 0.8 1.6e-05 24.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK49285.1 - 3.7e-14 52.8 9.6 3.7e-07 30.3 0.6 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK49285.1 - 2.6e-12 46.2 0.1 8.7e-05 22.1 0.0 2.7 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 PIK49285.1 - 4.7e-11 42.3 0.0 0.028 14.8 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK49285.1 - 6.7e-11 41.7 3.4 0.016 15.1 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49285.1 - 1.1e-10 40.9 0.2 0.00046 20.2 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK49285.1 - 1.2e-10 41.8 0.0 7.9e-07 29.6 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK49285.1 - 4.1e-08 32.7 0.8 0.098 12.7 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK49285.1 - 0.00021 21.9 0.0 0.75 10.8 0.0 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49285.1 - 0.00051 20.5 0.1 0.011 16.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK49285.1 - 0.0034 17.9 0.1 1.6 9.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK49285.1 - 0.0073 15.7 0.2 0.012 15.0 0.2 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_4 PF07721.14 PIK49285.1 - 0.0097 16.4 0.0 6 7.8 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK49285.1 - 0.037 13.5 0.0 0.074 12.5 0.0 1.5 1 0 0 1 1 1 0 SHNi-TPR EST1_DNA_bind PF10373.9 PIK49285.1 - 0.046 13.2 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain DUF1899 PF08953.11 PIK49285.1 - 0.27 11.2 2.0 0.62 10.0 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) OppC_N PF12911.7 PIK49285.1 - 4.3 7.4 5.9 9.3 6.3 0.1 3.3 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C PMT PF02366.18 PIK49286.1 - 2.9e-07 30.3 1.7 3.7e-07 30.0 1.7 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.6 PIK49286.1 - 0.0071 16.6 0.2 0.011 15.9 0.2 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF92 PF01940.16 PIK49287.1 - 6.1e-72 241.9 5.9 7.5e-72 241.5 5.9 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 CD99L2 PF12301.8 PIK49287.1 - 0.059 13.7 0.3 0.11 12.7 0.3 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 DSPc PF00782.20 PIK49288.1 - 8.1e-42 142.2 0.0 1.6e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK49288.1 - 0.00021 20.9 0.0 0.00042 20.0 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK49288.1 - 0.057 13.5 0.0 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate Pkinase_Tyr PF07714.17 PIK49289.1 - 2.7e-22 79.3 0.0 3.5e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49289.1 - 3e-22 79.3 0.0 4.4e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Exo_endo_phos PF03372.23 PIK49290.1 - 1.3e-09 37.9 0.0 2.4e-09 37.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Leptin PF02024.15 PIK49290.1 - 0.068 13.0 0.0 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 Leptin Ribosomal_L7Ae PF01248.26 PIK49291.1 - 9.9e-15 54.1 1.0 2.4e-14 52.8 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family QIL1 PF15884.5 PIK49292.1 - 2.1e-10 41.0 0.6 3.1e-10 40.5 0.6 1.3 1 0 0 1 1 1 1 MICOS complex subunit MIC13, QIL1 DPPIV_N PF00930.21 PIK49293.1 - 3.9e-67 226.5 0.5 5.7e-67 226.0 0.5 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 PIK49293.1 - 1.2e-53 181.7 0.0 2e-53 181.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 PIK49293.1 - 7.8e-09 35.5 0.4 7.2e-08 32.3 0.2 2.1 1 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 PIK49293.1 - 0.00015 21.5 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 PIK49293.1 - 0.00058 19.6 0.2 0.0017 18.0 0.2 1.8 1 1 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 PIK49293.1 - 0.0014 19.3 0.0 0.0071 17.0 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK49293.1 - 0.0018 17.6 0.1 0.04 13.2 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 PIK49293.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 PIK49293.1 - 0.025 14.1 0.0 0.18 11.3 0.0 2.1 1 1 0 1 1 1 0 Dienelactone hydrolase family Esterase_phd PF10503.9 PIK49293.1 - 0.18 11.2 0.0 0.8 9.1 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase SBP56 PF05694.11 PIK49295.1 - 4e-214 711.6 0.0 4.5e-214 711.4 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 PIK49295.1 - 0.00014 21.3 0.0 0.001 18.4 0.0 2.0 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DDE_Tnp_4 PF13359.6 PIK49296.1 - 3.3e-12 46.3 0.0 5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.6 PIK49296.1 - 0.0046 16.7 0.0 0.0085 15.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease Plant_tran PF04827.14 PIK49296.1 - 0.031 13.9 0.0 0.087 12.4 0.0 1.7 2 0 0 2 2 2 0 Plant transposon protein Sulfotransfer_2 PF03567.14 PIK49297.1 - 8.4e-09 35.7 0.2 1.7e-08 34.7 0.2 1.5 1 1 0 1 1 1 1 Sulfotransferase family Pro_isomerase PF00160.21 PIK49298.1 - 9.7e-46 155.9 0.2 2.8e-45 154.4 0.2 1.9 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.9 PIK49298.1 - 4e-06 26.6 23.6 4e-06 26.6 23.6 4.5 4 1 1 5 5 5 1 Nuclear RNA-splicing-associated protein Translin PF01997.16 PIK49299.1 - 1.3e-34 120.0 0.2 1.6e-34 119.7 0.2 1.1 1 0 0 1 1 1 1 Translin family TBPIP_N PF15517.6 PIK49299.1 - 0.02 14.9 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 TBP-interacting protein N-terminus Allexi_40kDa PF05549.11 PIK49299.1 - 0.048 13.2 0.2 0.073 12.6 0.2 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein IL17R_fnIII_D1 PF16556.5 PIK49301.1 - 0.00061 19.5 0.0 7.8 6.1 0.0 3.7 2 1 1 3 3 3 2 Interleukin-17 receptor, fibronectin-III-like domain 1 HTH_9 PF08221.11 PIK49301.1 - 0.014 15.5 2.7 60 3.8 0.0 5.3 6 0 0 6 6 6 0 RNA polymerase III subunit RPC82 helix-turn-helix domain UNC119_bdg PF15435.6 PIK49301.1 - 0.029 13.9 8.8 4.9 6.7 0.1 4.8 1 1 4 5 5 5 0 UNC119-binding protein C5orf30 homologue Phage-tail_3 PF13550.6 PIK49301.1 - 0.033 14.1 0.2 8 6.3 0.1 2.7 2 1 0 2 2 2 0 Putative phage tail protein TDP43_N PF18694.1 PIK49301.1 - 1.1 9.2 10.1 31 4.5 0.1 5.1 6 0 0 6 6 6 0 Transactive response DNA-binding protein N-terminal domain Lycopene_cycl PF05834.12 PIK49301.1 - 1.3 8.0 3.9 34 3.3 0.1 3.6 1 1 3 4 4 4 0 Lycopene cyclase protein Stn1_C PF12659.7 PIK49301.1 - 2.5 8.1 13.8 4.6 7.2 0.1 4.5 3 1 2 5 5 5 0 Telomere capping C-terminal wHTH Tmemb_161AB PF10268.9 PIK49302.1 - 5.3e-118 394.7 4.8 5.9e-118 394.5 4.8 1.0 1 0 0 1 1 1 1 Predicted transmembrane protein 161AB BaxI_1 PF12811.7 PIK49302.1 - 0.62 9.6 8.2 0.061 12.9 3.7 1.6 2 0 0 2 2 2 0 Bax inhibitor 1 like Homeodomain PF00046.29 PIK49303.1 - 2.3e-21 75.4 5.1 3.6e-21 74.8 5.1 1.3 1 0 0 1 1 1 1 Homeodomain Engrail_1_C_sig PF10525.9 PIK49303.1 - 1.1e-14 53.4 0.1 2.2e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain Homeobox_KN PF05920.11 PIK49303.1 - 0.00062 19.6 2.6 0.00075 19.3 0.6 2.0 1 1 1 2 2 2 1 Homeobox KN domain CENP-B_N PF04218.13 PIK49303.1 - 0.004 16.7 1.2 0.0055 16.3 0.3 1.7 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain Snf7 PF03357.21 PIK49306.1 - 3.4e-50 170.0 16.6 4.1e-50 169.8 16.6 1.0 1 0 0 1 1 1 1 Snf7 DUF1959 PF09218.10 PIK49306.1 - 0.012 15.8 0.3 0.012 15.8 0.3 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1959) Dak2 PF02734.17 PIK49306.1 - 0.015 15.2 0.8 0.02 14.8 0.8 1.3 1 0 0 1 1 1 0 DAK2 domain Leu_zip PF15294.6 PIK49306.1 - 0.033 13.7 12.1 0.049 13.1 12.1 1.2 1 0 0 1 1 1 0 Leucine zipper BCDHK_Adom3 PF10436.9 PIK49306.1 - 0.04 13.7 1.9 0.054 13.3 1.9 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Hydantoinase_B PF02538.14 PIK49306.1 - 0.18 10.2 0.7 0.21 9.9 0.7 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase Uso1_p115_C PF04871.13 PIK49306.1 - 0.21 11.9 23.1 94 3.4 23.1 2.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region YlbE PF14003.6 PIK49306.1 - 0.29 11.6 3.8 0.16 12.4 0.8 2.1 2 0 0 2 2 2 0 YlbE-like protein DUF1319 PF07028.11 PIK49306.1 - 0.56 10.4 6.5 0.19 12.0 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) NPV_P10 PF05531.12 PIK49306.1 - 0.69 10.4 6.5 0.53 10.8 3.1 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 PIK49306.1 - 0.83 10.1 11.9 0.57 10.6 0.3 3.3 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF3573 PF12097.8 PIK49306.1 - 0.9 8.3 2.8 1.1 8.0 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CorA PF01544.18 PIK49306.1 - 1.4 8.1 9.5 0.48 9.7 5.6 2.0 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Laminin_II PF06009.12 PIK49306.1 - 1.6 8.8 8.0 0.81 9.7 1.9 2.2 1 1 1 2 2 2 0 Laminin Domain II Endotoxin_N PF03945.14 PIK49306.1 - 1.7 8.3 6.3 3.1 7.5 0.2 2.1 1 1 1 2 2 2 0 delta endotoxin, N-terminal domain DUF848 PF05852.11 PIK49306.1 - 2 8.5 11.1 0.65 10.1 5.3 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF948 PF06103.11 PIK49306.1 - 2.5 8.4 4.7 5.2 7.4 3.7 2.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlxA PF14282.6 PIK49306.1 - 6.1 6.9 15.2 3.1 7.8 10.4 2.3 1 1 1 2 2 2 0 FlxA-like protein TMPIT PF07851.13 PIK49306.1 - 7.9 5.6 11.9 2.7 7.2 6.7 1.9 1 1 1 2 2 2 0 TMPIT-like protein HYR PF02494.16 PIK49308.1 - 1.5e-122 400.1 39.7 3.5e-23 81.7 0.5 7.0 6 1 1 7 7 7 7 HYR domain DUF5011 PF16403.5 PIK49308.1 - 0.0021 18.2 0.1 35 4.6 0.0 5.5 6 0 0 6 6 6 1 Domain of unknown function (DUF5011) fn3 PF00041.21 PIK49308.1 - 0.011 16.0 13.0 0.82 10.1 0.1 6.3 6 2 1 7 7 7 0 Fibronectin type III domain Big_4 PF07532.11 PIK49308.1 - 0.038 13.7 20.2 0.3 10.9 0.4 5.5 6 0 0 6 6 6 0 Bacterial Ig-like domain (group 4) Reeler PF02014.16 PIK49308.1 - 0.13 13.1 5.5 17 6.1 0.0 4.9 3 1 3 6 6 6 0 Reeler domain HYR PF02494.16 PIK49309.1 - 4e-175 568.6 56.0 2e-21 76.1 3.7 10.2 10 0 0 10 10 10 10 HYR domain Mago-bind PF09282.10 PIK49310.1 - 2.9e-15 55.8 0.4 5.8e-15 54.8 0.4 1.5 1 0 0 1 1 1 1 Mago binding NPR3 PF03666.13 PIK49310.1 - 0.091 11.5 9.9 0.12 11.2 9.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF948 PF06103.11 PIK49310.1 - 0.28 11.5 1.6 0.41 10.9 1.3 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Cob_adeno_trans PF01923.18 PIK49310.1 - 0.39 10.9 3.9 0.48 10.5 3.9 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF1664 PF07889.12 PIK49310.1 - 0.95 9.5 7.8 0.11 12.5 3.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FAM60A PF15396.6 PIK49310.1 - 1.3 9.0 11.9 1.8 8.5 11.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A FHIPEP PF00771.20 PIK49310.1 - 2.8 6.3 5.6 3.2 6.1 5.6 1.1 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.16 PIK49310.1 - 5.3 7.0 5.8 5.7 6.9 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paramyxo_ncap PF00973.19 PIK49310.1 - 6.4 5.6 9.9 7.4 5.4 9.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Actin PF00022.19 PIK49311.1 - 2.3e-148 494.1 0.0 7.7e-148 492.4 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 PIK49311.1 - 0.071 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Spore germination GerD central core domain Actin PF00022.19 PIK49312.1 - 3.8e-117 391.3 0.0 1.6e-116 389.3 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 PIK49312.1 - 0.045 13.7 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Spore germination GerD central core domain Sulfotransfer_2 PF03567.14 PIK49313.1 - 2.5e-14 53.8 0.0 5.7e-14 52.6 0.0 1.5 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK49313.1 - 0.0023 17.4 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Fibrinogen_C PF00147.18 PIK49316.1 - 3.7e-73 246.0 0.2 4.5e-73 245.7 0.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SPATA48 PF15073.6 PIK49317.1 - 1.1e-36 125.9 0.9 2.3e-36 124.9 0.9 1.5 1 0 0 1 1 1 1 Spermatogenesis-associated protein 48 Sulfotransfer_2 PF03567.14 PIK49318.1 - 1.7e-15 57.6 0.3 3.2e-15 56.7 0.3 1.4 1 1 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK49318.1 - 1.2e-06 27.7 0.1 2.2e-06 26.8 0.1 1.5 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK49318.1 - 0.037 13.5 0.3 0.2 11.1 0.2 2.4 1 1 0 1 1 1 0 Sulfotransferase domain EamA PF00892.20 PIK49319.1 - 2.4e-17 63.4 9.2 3.3e-17 63.0 9.2 1.2 1 0 0 1 1 1 1 EamA-like transporter family NMU PF02070.15 PIK49319.1 - 0.13 12.2 1.4 5.7 6.9 0.4 2.8 3 0 0 3 3 3 0 Neuromedin U DNA_mis_repair PF01119.19 PIK49320.1 - 4.7e-19 68.2 0.3 6.5e-18 64.5 0.0 2.6 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 PIK49320.1 - 2e-11 43.8 0.1 4.3e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box PF00505.19 PIK49320.1 - 3.3e-08 33.8 0.1 9.7e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HATPase_c PF02518.26 PIK49320.1 - 1.3e-06 28.9 0.1 3.9e-06 27.3 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box_2 PF09011.10 PIK49320.1 - 0.0034 17.9 0.0 0.0087 16.6 0.0 1.7 1 0 0 1 1 1 1 HMG-box domain CLN5 PF15014.6 PIK49320.1 - 0.14 11.8 0.0 0.61 9.7 0.0 1.9 1 1 1 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 5 WD40 PF00400.32 PIK49321.1 - 2e-31 107.5 31.2 2.8e-06 27.9 2.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49321.1 - 3.8e-06 27.1 6.5 0.069 13.5 0.2 5.0 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 PIK49321.1 - 4.4e-05 23.9 0.1 7.4e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 PIK49321.1 - 0.025 13.3 8.6 0.34 9.5 3.4 3.3 1 1 2 3 3 3 0 Nucleoporin Nup120/160 LRR_9 PF14580.6 PIK49322.1 - 3.1e-15 56.1 2.9 2.2e-06 27.3 0.0 3.2 3 0 0 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 PIK49322.1 - 1e-12 48.0 21.5 0.0038 17.6 1.9 5.9 3 3 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK49322.1 - 1.6e-10 40.6 11.2 0.00033 20.4 2.4 3.8 3 1 0 3 3 3 2 Leucine rich repeat DUF2457 PF10446.9 PIK49322.1 - 1.2 8.2 4.2 0.25 10.4 1.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) LRR_1 PF00560.33 PIK49322.1 - 1.2 9.9 11.7 26 5.9 0.2 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat Clathrin_lg_ch PF01086.17 PIK49323.1 - 1.1e-35 123.8 16.3 1.4e-35 123.5 16.3 1.1 1 0 0 1 1 1 1 Clathrin light chain TraB PF01963.17 PIK49323.1 - 0.21 11.5 4.1 0.29 11.0 4.1 1.2 1 0 0 1 1 1 0 TraB family TMEM154 PF15102.6 PIK49324.1 - 0.0077 16.1 6.1 0.026 14.4 6.1 1.8 1 1 0 1 1 1 1 TMEM154 protein family Stevor PF17410.2 PIK49324.1 - 0.011 15.3 0.9 0.014 14.9 0.9 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF1180 PF06679.12 PIK49324.1 - 0.015 15.7 0.3 0.021 15.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_M56 PF05569.11 PIK49324.1 - 0.022 14.0 0.2 0.029 13.6 0.2 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Orf78 PF06024.12 PIK49324.1 - 0.12 12.7 0.1 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF4834 PF16118.5 PIK49324.1 - 0.12 13.4 0.2 0.68 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Piwi PF02171.17 PIK49325.1 - 1.4e-72 244.5 3.1 2.5e-40 138.6 0.0 3.2 2 1 1 3 3 3 3 Piwi domain ArgoMid PF16487.5 PIK49325.1 - 7.7e-33 112.6 0.2 2.1e-32 111.2 0.2 1.8 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 PIK49325.1 - 2.1e-29 102.9 0.0 1.4e-28 100.3 0.0 2.3 3 0 0 3 3 3 1 N-terminal domain of argonaute PAZ PF02170.22 PIK49325.1 - 1.2e-25 89.9 0.3 2.2e-25 89.1 0.3 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 PIK49325.1 - 4e-23 80.8 0.1 7.8e-23 79.9 0.1 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 PIK49325.1 - 8.8e-13 48.4 0.0 1.8e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain Ku PF02735.16 PIK49326.1 - 1.6e-42 145.5 0.0 2.8e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 PIK49326.1 - 4.4e-34 117.2 2.7 4.4e-34 117.2 2.7 2.0 2 0 0 2 2 2 1 Ku C terminal domain like Ku_N PF03731.15 PIK49326.1 - 6.7e-22 78.3 0.2 3.1e-21 76.1 0.0 2.0 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 PIK49326.1 - 7.2e-11 42.6 2.4 2.9e-10 40.7 0.1 2.9 3 0 0 3 3 3 1 Ku70/Ku80 C-terminal arm Methyltransf_16 PF10294.9 PIK49327.1 - 7.1e-43 146.3 0.0 8.3e-43 146.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 PIK49327.1 - 0.0013 18.3 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MethyltransfD12 PF02086.15 PIK49327.1 - 0.052 13.2 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_23 PF13489.6 PIK49327.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DAGK_acc PF00609.19 PIK49328.1 - 3.4e-45 154.2 0.0 7e-45 153.2 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 PIK49328.1 - 7.8e-17 61.1 0.0 1.6e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.23 PIK49328.1 - 4.3e-16 59.3 0.0 7e-11 42.6 0.0 2.6 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 PIK49328.1 - 1.9e-11 43.7 17.1 4.5e-10 39.3 10.4 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) TUG-UBL1 PF11470.8 PIK49328.1 - 0.016 15.4 0.0 7 7.0 0.0 2.9 3 0 0 3 3 3 0 TUG ubiquitin-like domain zf-RING_UBOX PF13445.6 PIK49329.1 - 1.1e-09 38.1 11.8 3.5e-09 36.5 6.3 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK49329.1 - 1.9e-07 31.1 9.8 1.9e-07 31.1 9.8 2.8 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK49329.1 - 2.4e-07 30.5 7.4 2.4e-07 30.5 7.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK49329.1 - 3.5e-07 29.9 7.8 3.5e-07 29.9 7.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK49329.1 - 3.3e-05 24.1 7.3 3.3e-05 24.1 7.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK49329.1 - 0.00021 21.1 6.1 0.00021 21.1 6.1 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK49329.1 - 0.00035 20.7 7.1 0.00035 20.7 7.1 2.9 4 0 0 4 4 4 1 B-box zinc finger zf-RING_5 PF14634.6 PIK49329.1 - 0.00087 19.2 6.8 0.00087 19.2 6.8 3.1 2 1 0 2 2 2 1 zinc-RING finger domain IBR PF01485.21 PIK49329.1 - 1.8 8.9 19.8 0.22 11.8 5.9 3.1 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-H2C2_2 PF13465.6 PIK49329.1 - 8.8 7.0 8.7 11 6.6 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double domain HYR PF02494.16 PIK49330.1 - 8.1e-34 115.8 18.0 5.4e-12 45.9 3.4 3.0 3 0 0 3 3 3 3 HYR domain DUF4402 PF14352.6 PIK49330.1 - 0.65 10.7 8.4 0.43 11.2 0.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4402) HYR PF02494.16 PIK49331.1 - 6.1e-25 87.4 5.4 4e-15 55.9 1.0 2.3 2 1 0 2 2 2 2 HYR domain HYR PF02494.16 PIK49332.1 - 5e-53 177.4 17.8 3.6e-22 78.5 1.0 3.0 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK49332.1 - 3.9e-06 26.9 4.0 0.048 13.8 1.1 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF5011) Big_9 PF17963.1 PIK49332.1 - 0.014 16.1 9.7 0.014 16.1 9.7 3.3 1 1 2 3 3 3 0 Bacterial Ig domain DUF4426 PF14467.6 PIK49332.1 - 0.024 14.6 0.0 0.58 10.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4426) DUF1833 PF08875.11 PIK49332.1 - 0.053 13.1 1.3 1.7 8.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) Pilin_N PF07790.11 PIK49332.1 - 0.11 13.4 0.2 2.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal DUF756 PF05506.12 PIK49332.1 - 0.15 13.0 1.0 7.3 7.6 0.1 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF756) Spindle_Spc25 PF08234.12 PIK49332.1 - 0.17 12.2 0.0 2.7 8.2 0.0 2.4 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 Cadherin_5 PF17892.1 PIK49332.1 - 0.19 11.7 9.3 0.2 11.6 1.6 3.1 3 0 0 3 3 3 0 Cadherin-like domain HYR PF02494.16 PIK49333.1 - 4.3e-44 148.7 9.8 3.5e-15 56.1 0.2 3.6 3 0 0 3 3 3 3 HYR domain SEA PF01390.20 PIK49333.1 - 2e-12 47.1 0.0 5.7e-10 39.2 0.1 2.6 2 0 0 2 2 2 1 SEA domain EGF_CA PF07645.15 PIK49333.1 - 6e-07 29.6 9.6 6e-07 29.6 9.6 2.6 2 0 0 2 2 2 1 Calcium-binding EGF domain EGF PF00008.27 PIK49333.1 - 3.7e-06 27.1 18.9 0.00042 20.6 4.8 2.7 2 0 0 2 2 2 2 EGF-like domain FXa_inhibition PF14670.6 PIK49333.1 - 0.0082 16.4 18.5 0.81 10.0 8.1 2.9 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site DUF5011 PF16403.5 PIK49333.1 - 0.026 14.6 0.4 14 5.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) hEGF PF12661.7 PIK49333.1 - 0.12 13.1 16.8 0.22 12.2 4.0 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_3 PF12947.7 PIK49333.1 - 0.18 12.0 18.1 0.1 12.8 4.2 2.9 3 0 0 3 3 3 0 EGF domain P-II PF00543.22 PIK49333.1 - 0.19 12.3 0.0 5.2 7.7 0.0 2.8 3 0 0 3 3 3 0 Nitrogen regulatory protein P-II Lipocalin_7 PF14651.6 PIK49334.1 - 5.6e-10 39.2 0.1 6.8e-10 39.0 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 PIK49335.1 - 7e-08 32.5 0.2 8e-08 32.3 0.2 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family T2SSN PF01203.19 PIK49335.1 - 0.043 14.0 0.1 0.053 13.7 0.1 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein N Ribosomal_L6 PF00347.23 PIK49335.1 - 0.071 13.8 1.3 0.66 10.7 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L6 Lipocalin PF00061.23 PIK49335.1 - 0.072 13.3 0.0 0.089 13.0 0.0 1.1 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Carn_acyltransf PF00755.20 PIK49336.1 - 1.7e-30 106.2 0.0 2.1e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Pro_dh-DNA_bdg PF14850.6 PIK49336.1 - 0.015 15.8 0.0 0.024 15.2 0.0 1.2 1 0 0 1 1 1 0 DNA-binding domain of Proline dehydrogenase Carn_acyltransf PF00755.20 PIK49337.1 - 6.7e-73 246.2 0.0 8.2e-73 246.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 PIK49338.1 - 4.6e-41 140.9 32.5 3.8e-37 128.0 27.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK49338.1 - 0.00028 19.9 2.4 0.00028 19.9 2.4 2.3 1 1 1 2 2 2 1 MFS_1 like family BT1 PF03092.16 PIK49338.1 - 0.0016 16.7 0.1 0.0016 16.7 0.1 1.7 2 0 0 2 2 2 1 BT1 family UNC-93 PF05978.16 PIK49338.1 - 0.0056 16.4 0.4 0.018 14.8 0.4 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Thioredoxin PF00085.20 PIK49339.1 - 3.5e-07 30.1 0.0 5.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 PIK49339.1 - 0.0041 17.0 0.3 0.0093 15.8 0.0 1.7 2 0 0 2 2 2 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 PIK49339.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family ELO PF01151.18 PIK49340.1 - 4.1e-54 183.8 21.2 4.8e-54 183.5 21.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family MULE PF10551.9 PIK49341.1 - 0.0077 16.6 0.2 0.015 15.7 0.2 1.4 1 0 0 1 1 1 1 MULE transposase domain Rab5-bind PF09311.11 PIK49341.1 - 0.052 12.9 0.6 0.074 12.4 0.6 1.1 1 0 0 1 1 1 0 Rabaptin-like protein AIG1 PF04548.16 PIK49343.1 - 8.5e-28 97.1 0.4 1.3e-27 96.5 0.4 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK49343.1 - 1.5e-07 31.4 0.2 2.2e-07 30.9 0.2 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK49343.1 - 0.00032 20.8 4.0 0.035 14.2 0.0 2.8 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK49343.1 - 0.00069 19.5 0.2 0.00098 19.1 0.2 1.3 1 0 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 PIK49343.1 - 0.0019 17.4 0.0 0.002 17.3 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 PIK49343.1 - 0.0026 18.1 0.1 0.0066 16.8 0.0 1.7 2 0 0 2 2 2 1 RNA helicase AIG1 PF04548.16 PIK49344.1 - 1.9e-12 47.0 0.9 2e-05 24.0 0.1 2.4 1 1 1 2 2 2 2 AIG1 family Med10 PF09748.9 PIK49344.1 - 0.023 14.6 0.6 0.023 14.6 0.6 2.0 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DDE_Tnp_1_7 PF13843.6 PIK49345.1 - 9.6e-77 258.6 0.1 1.1e-76 258.5 0.1 1.0 1 0 0 1 1 1 1 Transposase IS4 DOCK_N PF16172.5 PIK49346.1 - 7.8e-96 321.3 0.1 1.6e-95 320.2 0.1 1.6 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 PIK49346.1 - 2.5e-87 293.7 14.9 2.5e-87 293.7 14.9 2.3 2 1 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 PIK49346.1 - 2.7e-56 190.5 0.3 7.2e-56 189.1 0.3 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 PIK49346.1 - 6.6e-06 25.9 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK49346.1 - 0.00014 21.5 0.0 0.00033 20.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK49346.1 - 0.0054 16.3 0.0 0.014 15.0 0.0 1.8 1 0 0 1 1 1 1 SH3 domain FANCI_S4 PF14678.6 PIK49347.1 - 2.7e-71 239.6 0.7 2.7e-71 239.6 0.7 3.8 2 1 1 3 3 3 1 FANCI solenoid 4 FANCI_S1 PF14675.6 PIK49347.1 - 4e-43 147.5 1.5 4e-43 147.5 1.5 2.2 3 0 0 3 3 3 1 FANCI solenoid 1 FANCI_S2 PF14676.6 PIK49347.1 - 1.8e-40 138.9 1.2 3.6e-40 137.9 0.1 2.2 2 0 0 2 2 2 1 FANCI solenoid 2 FANCI_HD2 PF14680.6 PIK49347.1 - 1.5e-31 109.5 0.9 1.5e-31 109.5 0.9 2.2 2 0 0 2 2 2 1 FANCI helical domain 2 FANCI_S3 PF14677.6 PIK49347.1 - 6e-26 91.5 1.7 6e-26 91.5 1.7 3.5 4 1 1 5 5 5 1 FANCI solenoid 3 FANCI_HD1 PF14679.6 PIK49347.1 - 1e-19 70.2 0.2 3.3e-19 68.6 0.2 1.9 1 0 0 1 1 1 1 FANCI helical domain 1 FANCI_S1-cap PF14674.6 PIK49347.1 - 4.1e-05 23.6 0.2 0.00021 21.3 0.2 2.4 1 0 0 1 1 1 1 FANCI solenoid 1 cap PBP1_TM PF14812.6 PIK49347.1 - 9.6 6.7 8.8 29 5.1 0.1 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RAWUL PF16207.5 PIK49348.1 - 8.2e-05 23.2 0.2 0.00017 22.2 0.2 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like APG12 PF04110.13 PIK49348.1 - 0.029 14.8 0.3 0.049 14.0 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-like autophagy protein Apg12 DUF3850 PF12961.7 PIK49348.1 - 0.073 13.1 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) Nop PF01798.18 PIK49349.1 - 5.2e-88 294.4 0.2 5.2e-88 294.4 0.2 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 PIK49349.1 - 8.9e-19 67.7 0.6 8.9e-19 67.7 0.6 2.1 2 0 0 2 2 2 1 NOP5NT (NUC127) domain UPF0688 PF15772.5 PIK49349.1 - 0.15 12.3 11.7 0.25 11.6 11.7 1.3 1 0 0 1 1 1 0 UPF0688 family DUF747 PF05346.11 PIK49350.1 - 4.1e-104 348.5 20.8 5.8e-104 348.0 20.8 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family FAM176 PF14851.6 PIK49350.1 - 0.064 12.9 0.5 0.13 11.9 0.5 1.5 1 0 0 1 1 1 0 FAM176 family CLTH PF10607.9 PIK49351.1 - 1e-31 109.8 0.5 1e-31 109.8 0.5 2.1 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 PIK49351.1 - 9.4e-06 25.6 0.2 1.8e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger DUF1664 PF07889.12 PIK49351.1 - 0.003 17.6 0.8 0.011 15.7 0.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) zf-RING_2 PF13639.6 PIK49351.1 - 0.0039 17.5 0.2 0.0075 16.6 0.2 1.5 1 0 0 1 1 1 1 Ring finger domain 7TMR-HDED PF07697.11 PIK49351.1 - 0.022 14.9 1.4 0.035 14.2 1.4 1.4 1 0 0 1 1 1 0 7TM-HD extracellular zf-C3HC4 PF00097.25 PIK49351.1 - 0.024 14.5 0.6 0.046 13.6 0.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK49351.1 - 0.069 13.1 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK49351.1 - 0.1 12.5 1.3 0.37 10.7 1.4 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Peptidase_S8 PF00082.22 PIK49352.1 - 0.00012 21.5 0.9 0.00017 21.0 0.9 1.3 1 1 0 1 1 1 1 Subtilase family Glyco_transf_10 PF00852.19 PIK49353.1 - 6.2e-38 130.3 0.0 8.8e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK49353.1 - 5.4e-05 23.6 0.0 8.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK49354.1 - 5.5e-29 101.1 0.0 8.2e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK49354.1 - 0.0011 19.4 0.0 0.0018 18.7 0.0 1.3 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal V-set PF07686.17 PIK49355.1 - 1.4e-07 31.7 0.1 0.013 15.6 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK49355.1 - 9.4e-07 29.4 0.3 0.26 11.9 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK49355.1 - 2.6e-05 24.2 0.1 0.035 14.2 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK49355.1 - 0.00019 21.5 1.4 0.69 10.1 0.0 4.3 5 0 0 5 5 5 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK49355.1 - 0.0098 15.9 0.1 1.5 8.9 0.0 2.8 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain ARGLU PF15346.6 PIK49355.1 - 0.021 14.7 5.8 0.032 14.1 5.8 1.2 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Perilipin PF03036.16 PIK49355.1 - 0.046 12.7 0.5 0.067 12.2 0.5 1.2 1 0 0 1 1 1 0 Perilipin family Ig_2 PF13895.6 PIK49355.1 - 0.59 10.5 3.9 5.3 7.5 0.0 4.1 5 1 0 5 5 5 0 Immunoglobulin domain RVT_1 PF00078.27 PIK49357.1 - 1.3e-34 119.7 1.5 1.5e-34 119.5 0.2 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK49357.1 - 4.3e-05 23.3 0.0 0.00017 21.4 0.0 2.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK49357.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family C2-set_2 PF08205.12 PIK49358.1 - 0.0067 16.5 2.0 2.1 8.5 0.1 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain MG4 PF17789.1 PIK49358.1 - 0.026 14.7 0.0 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 Macroglobulin domain MG4 FLYWCH PF04500.16 PIK49359.1 - 3.2e-07 30.4 0.2 5.5e-07 29.6 0.2 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain NAD_kinase PF01513.21 PIK49360.1 - 1.2e-36 126.5 0.1 6.8e-18 64.9 0.0 2.1 2 0 0 2 2 2 2 ATP-NAD kinase DAGK_cat PF00781.24 PIK49360.1 - 0.034 13.8 0.0 0.064 12.9 0.0 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain HEAT PF02985.22 PIK49361.1 - 7e-07 29.0 3.0 0.9 10.0 0.0 7.1 7 0 0 7 7 7 2 HEAT repeat CLASP_N PF12348.8 PIK49361.1 - 0.0024 17.4 0.8 0.014 15.0 0.1 2.6 3 0 0 3 3 3 1 CLASP N terminal HEAT_EZ PF13513.6 PIK49361.1 - 0.0084 16.6 9.8 3.5 8.2 0.2 5.7 5 0 0 5 5 5 2 HEAT-like repeat Cnd1_N PF12922.7 PIK49362.1 - 2.3e-38 131.6 0.2 5.3e-38 130.5 0.2 1.7 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 PIK49362.1 - 0.0065 16.6 1.7 0.24 11.8 0.1 4.2 3 0 0 3 3 3 1 HEAT repeat RTP1_C1 PF10363.9 PIK49362.1 - 0.022 14.9 0.1 0.16 12.1 0.1 2.6 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4279 PF14106.6 PIK49362.1 - 0.032 14.4 0.1 2.7 8.2 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4279) Cnd1 PF12717.7 PIK49362.1 - 0.036 14.1 0.7 0.44 10.6 0.0 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Med30 PF11315.8 PIK49362.1 - 0.04 14.1 0.3 0.14 12.4 0.3 1.9 1 0 0 1 1 1 0 Mediator complex subunit 30 TetR_C_5 PF08360.11 PIK49362.1 - 0.054 13.7 0.0 0.25 11.5 0.0 2.1 1 0 0 1 1 1 0 QacR-like protein, C-terminal region HEAT_2 PF13646.6 PIK49362.1 - 0.097 13.1 1.1 9.9 6.6 0.2 3.8 2 2 2 4 4 4 0 HEAT repeats Cohesin_HEAT PF12765.7 PIK49362.1 - 0.13 12.6 0.1 0.4 11.0 0.1 1.9 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 PIK49363.1 - 5.1e-51 172.9 0.5 1.9e-50 171.1 0.1 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK49363.1 - 3.5e-05 22.6 0.5 0.0003 19.5 0.4 2.2 1 1 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.22 PIK49363.1 - 0.0032 17.6 1.0 2.7 8.5 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 PIK49363.1 - 0.0085 16.5 0.0 0.036 14.5 0.0 2.2 2 0 0 2 2 2 1 HEAT repeats Cnd3 PF12719.7 PIK49363.1 - 0.014 14.6 0.7 0.03 13.5 0.1 1.9 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain ANF_receptor PF01094.28 PIK49365.1 - 7.2e-51 173.3 0.0 8.5e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK49365.1 - 1.4e-07 31.6 0.0 3.7e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein PT-VENN PF04829.13 PIK49365.1 - 0.026 14.6 0.2 0.056 13.5 0.2 1.5 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif 7tm_3 PF00003.22 PIK49366.1 - 1.1e-51 175.8 25.2 1.6e-51 175.4 25.2 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK49366.1 - 3e-14 52.7 11.9 3e-14 52.7 11.9 1.7 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Ank_2 PF12796.7 PIK49367.1 - 2.3e-19 69.7 0.3 3.6e-10 40.3 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK49367.1 - 1.8e-16 60.3 0.6 3.1e-09 37.2 0.1 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK49367.1 - 1.2e-13 50.9 0.4 6.4e-08 32.7 0.1 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK49367.1 - 8.6e-12 44.2 0.2 0.021 15.3 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK49367.1 - 1.4e-09 38.0 1.1 0.0028 18.0 0.0 4.3 5 0 0 5 5 5 3 Ankyrin repeat Pkinase_Tyr PF07714.17 PIK49369.1 - 2.4e-87 292.5 0.0 3.7e-87 291.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49369.1 - 2.9e-44 151.4 0.0 4.7e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain GTPase_binding PF09027.10 PIK49369.1 - 8.4e-13 48.1 0.7 3e-12 46.3 0.6 2.0 2 0 0 2 2 2 1 GTPase binding UBA_4 PF14555.6 PIK49369.1 - 1e-05 25.3 1.1 0.091 12.6 0.2 2.8 3 0 0 3 3 3 2 UBA-like domain Kinase-like PF14531.6 PIK49369.1 - 0.00033 20.1 0.0 0.00058 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK49369.1 - 0.0086 15.1 0.0 0.0086 15.1 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain SH3_2 PF07653.17 PIK49369.1 - 0.037 13.7 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain TAP_C PF03943.13 PIK49369.1 - 0.082 12.6 0.1 18 5.1 0.0 2.6 2 0 0 2 2 2 0 TAP C-terminal domain SH3_9 PF14604.6 PIK49369.1 - 0.09 12.7 0.3 0.65 9.9 0.3 2.2 1 1 0 1 1 1 0 Variant SH3 domain Gp_dh_C PF02800.20 PIK49370.1 - 1.6e-57 193.6 0.0 4.5e-57 192.1 0.0 1.7 1 1 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 PIK49370.1 - 9e-34 115.9 0.1 3e-33 114.2 0.0 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain zf-RING_2 PF13639.6 PIK49371.1 - 2.5e-09 37.3 13.8 5.3e-09 36.3 13.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 PIK49371.1 - 3.8e-07 30.3 10.1 3.8e-07 30.3 10.1 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 PIK49371.1 - 1.2e-05 25.1 13.0 2.6e-05 24.0 13.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK49371.1 - 5.4e-05 23.0 11.0 0.0001 22.1 11.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK49371.1 - 0.00011 22.1 9.6 0.00012 22.0 7.8 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK49371.1 - 0.00029 20.7 10.8 0.00056 19.8 10.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain HALZ PF02183.18 PIK49371.1 - 0.00066 19.8 21.9 0.26 11.6 0.7 4.8 4 1 0 4 4 4 2 Homeobox associated leucine zipper JIP_LZII PF16471.5 PIK49371.1 - 0.0011 19.1 28.4 0.0048 17.0 3.7 4.6 2 1 0 4 4 4 2 JNK-interacting protein leucine zipper II Prok-RING_4 PF14447.6 PIK49371.1 - 0.0019 18.0 10.7 0.0047 16.8 10.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK49371.1 - 0.0054 16.5 10.3 0.0054 16.5 10.3 2.2 2 0 0 2 2 2 1 RING-like zinc finger RINGv PF12906.7 PIK49371.1 - 0.0063 16.6 11.1 0.015 15.4 11.1 1.7 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.25 PIK49371.1 - 0.0068 16.3 13.1 0.017 15.0 13.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 PIK49371.1 - 0.0075 16.0 9.1 0.017 14.9 9.1 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 PIK49371.1 - 0.011 15.4 10.5 0.021 14.4 10.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 PIK49371.1 - 0.015 15.4 5.2 0.027 14.5 5.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 PIK49371.1 - 0.03 14.5 0.0 1.5 9.1 0.0 2.7 2 0 0 2 2 2 0 U-box domain Sec34 PF04136.15 PIK49371.1 - 0.036 13.9 18.2 0.071 13.0 1.6 3.3 1 1 1 3 3 3 0 Sec34-like family GAS PF13851.6 PIK49371.1 - 0.047 13.0 32.7 0.028 13.8 15.6 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Macoilin PF09726.9 PIK49371.1 - 0.078 11.5 22.8 0.12 11.0 22.8 1.2 1 0 0 1 1 1 0 Macoilin family IFT57 PF10498.9 PIK49371.1 - 0.22 10.4 25.9 0.024 13.6 11.7 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Prok-RING_1 PF14446.6 PIK49371.1 - 0.28 11.1 10.8 0.59 10.1 7.3 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 LOH1CR12 PF10158.9 PIK49371.1 - 0.32 11.0 8.1 2.6 8.1 2.0 2.5 2 0 0 2 2 2 0 Tumour suppressor protein DUF2570 PF10828.8 PIK49371.1 - 0.42 10.4 15.0 0.88 9.4 2.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) CENP-F_leu_zip PF10473.9 PIK49371.1 - 0.52 10.3 33.3 3.7 7.6 22.6 2.7 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1465 PF07323.12 PIK49371.1 - 0.62 9.9 17.2 0.54 10.1 6.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1465) DivIC PF04977.15 PIK49371.1 - 0.76 9.6 27.2 1.6 8.5 5.3 4.3 1 1 3 4 4 4 0 Septum formation initiator OrfB_Zn_ribbon PF07282.11 PIK49371.1 - 1.3 9.0 7.5 3.4 7.7 0.1 2.9 3 0 0 3 3 2 0 Putative transposase DNA-binding domain DUF4988 PF16378.5 PIK49371.1 - 1.3 8.6 6.3 17 5.1 1.1 2.9 2 1 1 3 3 3 0 Domain of unknown function CheZ PF04344.13 PIK49371.1 - 1.7 8.5 13.9 0.9 9.4 5.6 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ DUF1664 PF07889.12 PIK49371.1 - 1.8 8.6 20.9 3.4 7.7 0.2 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 PIK49371.1 - 2.1 8.6 28.8 0.44 10.8 10.0 3.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ADIP PF11559.8 PIK49371.1 - 3.5 7.7 26.9 0.89 9.6 9.2 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.8 PIK49371.1 - 3.7 7.8 28.5 0.18 12.0 10.7 3.8 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 PIK49371.1 - 4.2 6.6 26.8 2.9 7.1 8.6 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DASH_Dad2 PF08654.10 PIK49371.1 - 5.4 7.5 13.8 1.2 9.6 2.4 3.4 2 2 1 3 3 3 0 DASH complex subunit Dad2 zf-TFIIIC PF12660.7 PIK49371.1 - 5.9 6.9 10.9 0.17 11.9 1.9 2.9 3 1 0 3 3 3 0 Putative zinc-finger of transcription factor IIIC complex FANCL_C PF11793.8 PIK49371.1 - 6.3 7.1 9.9 37 4.6 9.9 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain YabA PF06156.13 PIK49371.1 - 6.7 7.4 25.3 2.5 8.8 3.4 4.0 1 1 1 2 2 1 0 Initiation control protein YabA DUF4407 PF14362.6 PIK49371.1 - 8.2 5.7 20.4 8.2e+02 -0.9 20.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 PIK49371.1 - 9.4 6.8 32.7 19 5.8 5.8 3.3 1 1 2 3 3 3 0 Apg6 coiled-coil region Lzipper-MIP1 PF14389.6 PIK49371.1 - 9.8 6.6 15.0 2.3 8.6 0.8 3.6 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Fibrinogen_C PF00147.18 PIK49372.1 - 6.7e-56 189.5 9.2 9.4e-56 189.1 9.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain zf-RING_11 PF17123.5 PIK49372.1 - 0.057 13.2 10.9 0.28 10.9 10.9 2.3 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 PIK49372.1 - 0.87 9.7 5.8 2.4 8.3 5.8 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Endomucin PF07010.12 PIK49372.1 - 0.95 9.4 20.9 1.5 8.8 20.9 1.2 1 0 0 1 1 1 0 Endomucin Mucin PF01456.17 PIK49372.1 - 3.1 7.8 56.4 0.73 9.8 35.8 2.3 1 1 1 2 2 2 0 Mucin-like glycoprotein Sulfotransfer_3 PF13469.6 PIK49374.1 - 7.9e-07 29.7 0.1 1.2e-06 29.0 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Glycos_transf_2 PF00535.26 PIK49375.1 - 5.3e-30 104.5 0.0 7.9e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK49375.1 - 8.9e-28 97.1 3.6 1.4e-27 96.5 3.6 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 PIK49375.1 - 3e-06 27.3 0.0 7.7e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 PIK49375.1 - 2.8e-05 24.8 0.3 0.2 12.4 0.1 3.1 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.14 PIK49375.1 - 6e-05 22.6 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK49375.1 - 0.003 17.1 0.0 0.0062 16.0 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 COesterase PF00135.28 PIK49376.1 - 2.7e-26 92.5 0.0 3e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK49377.1 - 6.3e-47 160.6 0.0 7.5e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family DUF1356 PF07092.12 PIK49378.1 - 1.4e-35 122.7 1.5 1.7e-35 122.4 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Prominin PF05478.11 PIK49378.1 - 0.0059 14.6 0.1 0.0076 14.3 0.1 1.1 1 0 0 1 1 1 1 Prominin Anti-TRAP PF15777.5 PIK49378.1 - 0.07 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Nop16 PF09420.10 PIK49379.1 - 0.097 12.7 1.4 0.094 12.7 1.4 1.1 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 Sulfotransfer_2 PF03567.14 PIK49380.1 - 9.8e-41 140.3 7.6 1.5e-40 139.7 7.6 1.3 1 0 0 1 1 1 1 Sulfotransferase family Herpes_IR6 PF06307.12 PIK49380.1 - 0.025 14.1 4.0 0.033 13.7 0.2 2.3 2 1 0 2 2 2 0 Herpesvirus IR6 protein Destabilase PF05497.12 PIK49381.1 - 9.6e-30 103.3 8.1 1.1e-29 103.2 8.1 1.0 1 0 0 1 1 1 1 Destabilase Destabilase PF05497.12 PIK49382.1 - 4.9e-29 101.1 5.5 4.9e-29 101.1 5.5 1.9 2 1 0 2 2 2 1 Destabilase AA_kinase PF00696.28 PIK49383.1 - 2.2e-56 191.1 0.0 2.6e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family DUF4203 PF13886.6 PIK49384.1 - 1.3e-17 64.1 34.5 1.9e-17 63.6 34.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF1616 PF07760.11 PIK49384.1 - 5.2 6.4 10.3 11 5.3 10.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Bac_surface_Ag PF01103.23 PIK49385.1 - 7.6e-56 189.9 1.7 1e-55 189.5 1.7 1.2 1 0 0 1 1 1 1 Surface antigen Ribosomal_S5 PF00333.20 PIK49385.1 - 0.055 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain SH3_1 PF00018.28 PIK49386.1 - 1.7e-15 56.4 0.2 1.7e-15 56.4 0.2 2.1 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 PIK49386.1 - 5.5e-13 48.6 0.4 5.5e-13 48.6 0.4 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK49386.1 - 1.4e-07 31.0 0.0 2.9e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Tetraspanin PF00335.20 PIK49387.1 - 3.1e-27 95.8 8.2 4.2e-27 95.4 8.2 1.1 1 0 0 1 1 1 1 Tetraspanin family MARVEL PF01284.23 PIK49387.1 - 0.46 10.5 10.0 1.2 9.2 10.0 1.7 1 1 0 1 1 1 0 Membrane-associating domain CD20 PF04103.15 PIK49387.1 - 1.1 9.3 19.0 30 4.7 0.0 3.4 1 1 1 2 2 2 0 CD20-like family Tetraspanin PF00335.20 PIK49388.1 - 4.2e-40 137.9 16.4 5e-40 137.6 16.4 1.1 1 0 0 1 1 1 1 Tetraspanin family Corona_M PF01635.18 PIK49388.1 - 0.12 11.7 1.9 0.23 10.7 1.9 1.5 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein Rubis-subs-bind PF09273.11 PIK49389.1 - 3.6e-13 50.3 0.3 6.7e-13 49.5 0.3 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 PIK49389.1 - 2.3e-10 41.1 0.1 9.2e-10 39.2 0.0 1.8 2 0 0 2 2 2 1 SET domain DUF2605 PF10792.9 PIK49389.1 - 0.021 14.7 0.3 0.042 13.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) SNF2_N PF00176.23 PIK49390.1 - 2.4e-52 177.8 0.0 4.6e-52 176.9 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK49390.1 - 3.5e-14 53.1 0.0 1.1e-13 51.5 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK49390.1 - 5.6e-12 46.0 0.0 1.5e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK49390.1 - 6.9e-05 22.7 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2439 PF10382.9 PIK49390.1 - 0.098 13.0 0.3 0.32 11.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) ERCC3_RAD25_C PF16203.5 PIK49390.1 - 0.12 11.6 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Cob_adeno_trans PF01923.18 PIK49391.1 - 9.8e-44 149.4 0.0 1.2e-43 149.1 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase TSP_1 PF00090.19 PIK49392.1 - 6.7e-07 29.4 5.4 6.7e-07 29.4 5.4 2.3 2 1 1 3 3 3 1 Thrombospondin type 1 domain DUF2116 PF09889.9 PIK49392.1 - 0.88 9.6 4.0 0.66 10.0 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PRIMA1 PF16101.5 PIK49393.1 - 0.095 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 LsmAD PF06741.13 PIK49394.1 - 9.2e-09 35.7 0.3 9.2e-09 35.7 0.3 1.9 2 0 0 2 2 2 1 LsmAD domain baeRF_family10 PF18854.1 PIK49394.1 - 0.15 12.3 1.4 4.1 7.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 DSBA PF01323.20 PIK49396.1 - 0.0079 16.0 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain CNH PF00780.22 PIK49398.1 - 1.3e-43 149.7 0.7 5.2e-43 147.6 0.3 2.1 2 0 0 2 2 2 1 CNH domain PH PF00169.29 PIK49398.1 - 2.1e-07 31.4 0.1 1.6e-06 28.5 0.0 2.5 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 PIK49398.1 - 2e-06 27.6 10.9 3.7e-06 26.7 10.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 PIK49398.1 - 7.1 6.8 7.8 21 5.3 7.8 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Lebercilin PF15619.6 PIK49399.1 - 0.01 15.5 32.9 0.01 15.5 32.9 6.5 1 1 4 6 6 6 0 Ciliary protein causing Leber congenital amaurosis disease Leu_zip PF15294.6 PIK49399.1 - 5.9 6.3 122.8 0.22 11.0 17.4 5.3 1 1 4 5 5 5 0 Leucine zipper APG6_N PF17675.1 PIK49400.1 - 0.0015 19.0 58.1 0.009 16.5 6.5 5.8 4 1 0 5 5 5 3 Apg6 coiled-coil region DUF745 PF05335.13 PIK49400.1 - 0.0062 16.3 1.5 0.0062 16.3 1.5 4.7 4 1 1 5 5 5 2 Protein of unknown function (DUF745) DUF16 PF01519.16 PIK49400.1 - 0.023 15.1 0.5 0.023 15.1 0.5 5.5 4 1 1 5 5 5 0 Protein of unknown function DUF16 Syntaxin-6_N PF09177.11 PIK49400.1 - 0.042 14.4 28.3 0.2 12.2 0.8 5.8 4 1 2 6 6 6 0 Syntaxin 6, N-terminal DUF4407 PF14362.6 PIK49400.1 - 0.052 12.9 21.2 0.64 9.3 1.7 3.5 2 1 0 3 3 3 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 PIK49400.1 - 0.11 12.5 55.7 0.12 12.4 15.9 5.8 4 1 1 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 PIK49400.1 - 0.12 12.4 11.1 5.9 6.9 0.7 4.4 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HCMV_UL139 PF12507.8 PIK49400.1 - 1 9.7 6.0 4.4 7.7 0.2 3.7 3 1 0 3 3 3 0 Human Cytomegalovirus UL139 protein DUF1192 PF06698.11 PIK49400.1 - 1.2 9.3 14.2 1.5 9.0 0.6 5.2 4 1 1 5 5 5 0 Protein of unknown function (DUF1192) DUF948 PF06103.11 PIK49400.1 - 1.3 9.3 13.7 23 5.4 1.0 5.2 4 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 PIK49400.1 - 1.8 8.8 52.4 0.12 12.6 7.6 5.7 3 1 2 5 5 5 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 PIK49400.1 - 3.5 7.7 30.9 8.1 6.5 1.3 5.4 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) LPP PF04728.13 PIK49400.1 - 8.7 6.8 7.5 11 6.5 0.4 4.1 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Abhydrolase_1 PF00561.20 PIK49401.1 - 4e-21 75.8 0.0 6.2e-16 58.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK49401.1 - 9.5e-15 54.5 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK49401.1 - 2.9e-14 54.2 0.0 3.5e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 PIK49401.1 - 4.9e-06 26.4 0.3 0.00022 21.0 0.2 2.4 2 1 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 PIK49401.1 - 8.7e-06 26.0 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Palm_thioest PF02089.15 PIK49401.1 - 0.0038 17.1 0.0 0.0053 16.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 PIK49401.1 - 0.0056 16.2 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Esterase PF00756.20 PIK49401.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.4 1 1 0 1 1 1 1 Putative esterase Chlorophyllase PF07224.11 PIK49401.1 - 0.011 14.7 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Torsin PF06309.11 PIK49401.1 - 0.02 15.0 0.0 0.05 13.7 0.0 1.7 2 0 0 2 2 2 0 Torsin Ndr PF03096.14 PIK49401.1 - 0.029 13.1 0.0 0.049 12.3 0.0 1.3 1 0 0 1 1 1 0 Ndr family Ribosomal_L18p PF00861.22 PIK49402.1 - 3.3e-05 24.2 0.0 5.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Ubie_methyltran PF01209.18 PIK49403.1 - 2.4e-89 298.6 0.0 5.5e-89 297.5 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 PIK49403.1 - 1.7e-17 63.8 0.0 4e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK49403.1 - 3e-17 63.1 0.0 4.7e-15 56.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK49403.1 - 7e-11 42.1 0.0 1.9e-08 34.2 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK49403.1 - 2.5e-08 34.6 0.0 2.3e-07 31.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK49403.1 - 8e-06 25.8 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 PIK49403.1 - 0.0093 15.8 0.1 0.058 13.2 0.0 2.3 2 1 1 3 3 3 1 Hypothetical methyltransferase Methyltransf_5 PF01795.19 PIK49403.1 - 0.079 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 MraW methylase family UPF0020 PF01170.18 PIK49403.1 - 0.082 12.6 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF4042 PF13251.6 PIK49404.1 - 1.8e-38 132.1 2.3 1.4e-37 129.2 0.1 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4042) HEAT PF02985.22 PIK49404.1 - 2e-05 24.4 1.3 0.18 12.1 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 PIK49404.1 - 0.012 16.2 0.2 1.8 9.2 0.1 3.1 2 1 0 2 2 2 0 HEAT-like repeat V-ATPase_H_C PF11698.8 PIK49404.1 - 0.017 15.3 1.1 8.1 6.6 0.0 2.7 3 0 0 3 3 3 0 V-ATPase subunit H DUF1981 PF09324.10 PIK49404.1 - 0.017 15.0 0.0 0.34 10.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) HEAT_2 PF13646.6 PIK49404.1 - 0.02 15.3 0.0 11 6.4 0.0 2.7 2 0 0 2 2 2 0 HEAT repeats LRR_8 PF13855.6 PIK49405.1 - 2e-35 120.3 97.7 1.3e-11 44.0 2.9 6.8 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 PIK49405.1 - 3.7e-12 46.3 13.6 2.2e-05 24.4 4.8 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK49405.1 - 8.9e-10 38.7 58.2 4.2e-05 23.8 1.7 8.1 4 3 3 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK49405.1 - 1.9e-07 30.8 23.1 0.0099 15.4 0.9 4.3 1 1 2 4 4 4 4 Leucine-rich repeat LRR_12 PF18837.1 PIK49405.1 - 0.65 9.7 5.4 8.6 6.1 0.1 4.3 4 0 0 4 4 4 0 Leucine-rich repeat LRR_1 PF00560.33 PIK49405.1 - 2.3 9.1 0.0 2.3 9.1 0.0 9.8 11 0 0 11 11 11 0 Leucine Rich Repeat LRRNT PF01462.18 PIK49405.1 - 4.4 7.1 5.9 2.6 7.8 0.9 2.6 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain BACK PF07707.15 PIK49406.1 - 4.2e-09 36.4 0.1 2.6e-07 30.7 0.1 2.2 1 1 1 2 2 2 2 BTB And C-terminal Kelch EAP30 PF04157.16 PIK49407.1 - 9.6e-71 237.8 0.5 1.1e-70 237.6 0.5 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Phage_Mu_Gam PF07352.12 PIK49407.1 - 0.037 14.0 2.8 0.082 12.8 2.8 1.5 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein LcrG PF07216.12 PIK49407.1 - 0.092 12.7 0.3 4.2 7.4 0.0 2.5 1 1 1 2 2 2 0 LcrG protein Ribosomal_L29e PF01779.17 PIK49407.1 - 0.16 12.3 0.8 0.74 10.2 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L29e protein family adh_short PF00106.25 PIK49408.1 - 1.6e-24 86.5 0.0 6.1e-19 68.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK49408.1 - 1.4e-17 64.0 0.0 3.4e-13 49.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK49408.1 - 6.8e-07 29.4 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 KR domain tRNA_anti-codon PF01336.25 PIK49409.1 - 0.033 14.2 0.0 0.41 10.7 0.0 2.4 2 1 0 2 2 2 0 OB-fold nucleic acid binding domain CHASE3 PF05227.13 PIK49409.1 - 0.054 13.4 0.1 2.5 8.0 0.0 2.8 3 0 0 3 3 3 0 CHASE3 domain SH2 PF00017.24 PIK49409.1 - 0.43 10.7 2.4 1.3 9.2 0.1 2.9 3 0 0 3 3 3 0 SH2 domain ThiS-like PF14453.6 PIK49409.1 - 2.3 8.3 5.0 2.8 8.0 0.0 3.5 4 0 0 4 4 4 0 ThiS-like ubiquitin NAD_binding_8 PF13450.6 PIK49411.1 - 1.6e-13 50.7 0.5 4.4e-13 49.3 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 PIK49411.1 - 1.6e-09 37.6 0.6 1.8e-08 34.1 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 PIK49411.1 - 2.5e-06 26.8 1.9 7.8e-06 25.2 1.2 2.0 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 PIK49411.1 - 0.0017 17.7 0.2 0.0049 16.1 0.2 1.7 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 PIK49411.1 - 0.0073 15.7 0.3 0.011 15.1 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 PIK49411.1 - 0.0079 15.5 1.2 0.012 14.9 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK49411.1 - 0.01 15.1 0.1 0.021 14.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK49411.1 - 0.035 14.7 0.3 0.09 13.3 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK49411.1 - 0.039 13.2 1.1 0.068 12.4 1.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 PIK49411.1 - 0.046 12.2 0.1 0.14 10.7 0.1 1.7 2 0 0 2 2 2 0 GDP dissociation inhibitor DAO PF01266.24 PIK49411.1 - 0.1 12.2 2.6 0.082 12.5 0.9 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK49411.1 - 0.14 10.8 1.9 0.82 8.3 2.3 1.9 2 1 1 3 3 3 0 HI0933-like protein MCRA PF06100.11 PIK49411.1 - 0.28 9.9 0.2 0.4 9.4 0.2 1.2 1 0 0 1 1 1 0 MCRA family Reeler PF02014.16 PIK49412.1 - 0.00015 22.5 0.1 0.00018 22.3 0.1 1.1 1 0 0 1 1 1 1 Reeler domain Cytochrom_C PF00034.21 PIK49413.1 - 6e-08 33.7 0.8 1.1e-07 32.9 0.8 1.5 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 PIK49413.1 - 2.6e-05 24.4 1.5 8.3e-05 22.8 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C1 PF02167.15 PIK49413.1 - 0.09 12.5 0.0 0.82 9.4 0.0 2.0 2 0 0 2 2 2 0 Cytochrome C1 family Cytochrom_C550 PF14495.6 PIK49413.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c-550 domain 7tm_1 PF00001.21 PIK49414.1 - 3e-46 157.9 0.5 4.7e-46 157.2 0.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK49414.1 - 2.1e-10 40.5 18.6 2.1e-10 40.5 18.6 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK49414.1 - 1.4e-05 25.0 6.2 1.4e-05 25.0 6.2 2.1 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK49414.1 - 0.00041 20.1 19.8 0.00041 20.1 19.8 3.0 2 2 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK49415.1 - 8.8e-34 117.0 13.3 1.1e-33 116.7 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK49415.1 - 1.9e-06 27.9 3.7 2.6e-06 27.4 3.6 1.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK49415.1 - 7.4e-06 25.5 9.5 7.4e-06 25.5 9.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK49415.1 - 6.6e-05 22.4 7.8 0.00014 21.3 7.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK49415.1 - 0.00012 21.8 9.1 0.00012 21.8 9.1 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx UPF0054 PF02130.17 PIK49416.1 - 2.4e-33 114.7 0.0 2.8e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 RPAP3_C PF13877.6 PIK49416.1 - 0.064 13.8 0.2 0.12 12.9 0.2 1.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 EF-hand_1 PF00036.32 PIK49417.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 PIK49418.1 - 3.8e-06 26.1 0.5 0.08 12.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK49418.1 - 6.9e-05 23.2 0.3 0.00018 21.9 0.3 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK49418.1 - 0.00027 20.6 0.1 0.8 9.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 PIK49418.1 - 0.0015 18.3 1.1 0.089 12.7 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK49418.1 - 0.0035 16.8 0.2 1.3 8.7 0.1 2.4 2 0 0 2 2 2 2 EF hand Serglycin PF04360.12 PIK49418.1 - 0.081 12.9 4.9 0.13 12.2 4.9 1.3 1 0 0 1 1 1 0 Serglycin EF-hand_1 PF00036.32 PIK49419.1 - 5.1e-06 25.7 0.4 0.04 13.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK49419.1 - 8.8e-05 22.9 1.1 0.00042 20.7 1.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK49419.1 - 0.00022 20.9 0.2 0.044 13.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK49419.1 - 0.0046 16.4 1.1 0.31 10.6 0.0 2.4 2 0 0 2 2 2 2 EF hand Filamin PF00630.19 PIK49420.1 - 7.7e-12 46.0 0.0 5.2e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat DUF1043 PF06295.12 PIK49420.1 - 0.0024 17.8 0.8 0.0048 16.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) Muted PF14942.6 PIK49420.1 - 0.034 14.5 2.9 0.058 13.7 2.9 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Invasin_D3 PF09134.10 PIK49420.1 - 0.061 13.6 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Invasin, domain 3 NDC10_II PF16787.5 PIK49421.1 - 0.14 11.2 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 DUF3053 PF11254.8 PIK49422.1 - 0.074 12.6 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Glyco_transf_7N PF13733.6 PIK49423.1 - 4.5e-39 133.2 0.1 5e-39 133.0 0.1 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 TPR_12 PF13424.6 PIK49424.1 - 1e-07 32.1 1.2 0.00057 20.1 0.0 3.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49424.1 - 2.3e-05 24.2 0.2 0.0023 17.9 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49424.1 - 3.8e-05 23.3 0.1 0.0084 15.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK49424.1 - 8.8e-05 22.1 0.0 0.071 12.8 0.0 3.3 3 0 0 3 3 3 1 TPR repeat SNAP PF14938.6 PIK49424.1 - 0.00017 21.1 0.5 0.00017 21.1 0.5 1.9 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_21 PF09976.9 PIK49424.1 - 0.0004 20.1 0.4 0.0049 16.6 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 PIK49424.1 - 0.01 15.3 1.2 0.01 15.3 1.2 2.0 2 1 0 2 2 2 0 MalT-like TPR region TPR_7 PF13176.6 PIK49424.1 - 0.014 15.4 0.9 1 9.5 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK49424.1 - 0.015 16.0 0.1 0.29 12.1 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK49424.1 - 0.017 15.7 0.2 1.8 9.3 0.1 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49424.1 - 0.029 14.6 0.1 2.1 8.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK49424.1 - 0.043 13.5 0.0 0.45 10.2 0.0 2.3 1 1 1 2 2 2 0 26S proteasome subunit RPN7 FH2 PF02181.23 PIK49425.1 - 8.7e-90 301.5 14.5 9.8e-90 301.4 14.5 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain GAS PF13851.6 PIK49425.1 - 0.0054 16.1 0.8 0.0054 16.1 0.8 2.9 2 2 0 3 3 3 1 Growth-arrest specific micro-tubule binding CDT1 PF08839.11 PIK49425.1 - 0.012 15.9 0.4 0.023 15.0 0.4 1.4 1 0 0 1 1 1 0 DNA replication factor CDT1 like TBCC_N PF16752.5 PIK49425.1 - 0.038 14.4 6.1 0.057 13.9 1.0 3.1 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain IL11 PF07400.11 PIK49425.1 - 0.038 13.6 1.5 0.16 11.6 0.3 2.5 2 1 0 2 2 2 0 Interleukin 11 DUF4618 PF15397.6 PIK49425.1 - 0.053 12.9 7.9 0.69 9.3 0.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) EAP30 PF04157.16 PIK49425.1 - 0.061 12.6 2.5 0.046 13.0 0.5 1.8 2 0 0 2 2 2 0 EAP30/Vps36 family TPR_MLP1_2 PF07926.12 PIK49425.1 - 0.067 13.3 0.5 0.067 13.3 0.5 2.7 3 0 0 3 3 2 0 TPR/MLP1/MLP2-like protein DUF4298 PF14131.6 PIK49425.1 - 0.07 13.1 8.5 1.4 8.9 0.1 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4298) Mis14 PF08641.12 PIK49425.1 - 0.071 13.4 2.6 0.46 10.8 0.0 2.8 3 0 0 3 3 3 0 Kinetochore protein Mis14 like OmpH PF03938.14 PIK49425.1 - 0.089 13.1 4.3 5.3 7.4 0.1 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TLE_N PF03920.15 PIK49425.1 - 0.15 12.1 3.0 2.1 8.5 0.0 2.7 2 0 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain DUF948 PF06103.11 PIK49425.1 - 0.27 11.5 3.0 0.34 11.2 0.4 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 PIK49425.1 - 0.49 10.8 6.8 5.7 7.4 0.3 3.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 PIK49425.1 - 0.61 10.1 7.8 0.79 9.8 0.2 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) KxDL PF10241.9 PIK49425.1 - 1 9.7 5.4 15 6.0 0.9 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein LPP PF04728.13 PIK49425.1 - 1 9.8 3.8 2 8.8 0.4 2.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ZapB PF06005.12 PIK49425.1 - 2.7 8.5 13.0 5.3 7.6 2.0 3.0 2 1 0 2 2 2 0 Cell division protein ZapB ABC1 PF03109.16 PIK49425.1 - 2.7 8.2 5.6 27 4.9 1.3 3.0 2 2 1 3 3 3 0 ABC1 family VPS11_C PF12451.8 PIK49425.1 - 3 8.1 9.0 2.4 8.5 0.1 4.3 5 1 0 5 5 5 0 Vacuolar protein sorting protein 11 C terminal DASH_Hsk3 PF08227.11 PIK49425.1 - 6 7.3 9.2 13 6.2 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like PDZ_6 PF17820.1 PIK49426.1 - 2.5e-14 52.9 0.0 5.7e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK49426.1 - 4e-13 49.5 0.0 7.1e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK49426.1 - 5.3e-09 36.3 0.0 1.2e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain CCM2_C PF16545.5 PIK49426.1 - 0.0031 18.0 0.5 0.25 11.9 0.0 2.4 2 0 0 2 2 2 1 Cerebral cavernous malformation protein, harmonin-homology GSCFA PF08885.11 PIK49427.1 - 0.0032 17.2 2.2 0.1 12.3 0.2 2.7 2 1 0 2 2 2 2 GSCFA family Cullin PF00888.22 PIK49427.1 - 0.068 11.8 0.1 0.1 11.2 0.1 1.2 1 0 0 1 1 1 0 Cullin family GSIII_N PF12437.8 PIK49428.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal Drf_FH1 PF06346.12 PIK49432.1 - 0.16 11.7 63.3 3.4 7.4 4.8 6.2 6 0 0 6 6 6 0 Formin Homology Region 1 MAP65_ASE1 PF03999.12 PIK49432.1 - 4 6.0 8.0 5.6 5.5 8.0 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Tektin PF03148.14 PIK49434.1 - 2.2e-94 316.3 9.3 2.5e-94 316.2 9.3 1.0 1 0 0 1 1 1 1 Tektin family V_ATPase_I PF01496.19 PIK49434.1 - 0.0031 15.5 2.5 0.0045 15.0 2.5 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CCDC144C PF14915.6 PIK49434.1 - 0.028 13.5 11.1 0.17 11.0 4.9 2.1 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region DUF745 PF05335.13 PIK49434.1 - 0.042 13.6 4.0 0.34 10.6 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Atg14 PF10186.9 PIK49434.1 - 0.054 12.6 8.7 0.08 12.0 8.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phlebovirus_NSM PF07246.11 PIK49434.1 - 0.086 12.2 5.1 0.18 11.2 3.7 2.2 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M MitMem_reg PF13012.6 PIK49434.1 - 0.12 12.9 3.9 0.38 11.2 0.2 2.4 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Prefoldin PF02996.17 PIK49434.1 - 0.24 11.3 3.7 1.8 8.5 0.6 2.4 2 0 0 2 2 2 0 Prefoldin subunit DUF1515 PF07439.11 PIK49434.1 - 0.41 10.7 2.1 2.6 8.1 2.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) YabA PF06156.13 PIK49434.1 - 0.68 10.6 5.8 7.3 7.3 2.0 2.5 2 1 0 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 PIK49434.1 - 0.75 10.0 9.8 0.36 11.0 5.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HR1 PF02185.16 PIK49434.1 - 0.91 9.7 7.4 0.15 12.2 1.5 2.6 2 1 0 2 2 2 0 Hr1 repeat MIP-T3_C PF17749.1 PIK49434.1 - 1.1 9.2 10.6 0.098 12.6 4.8 2.1 2 1 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region FAM76 PF16046.5 PIK49434.1 - 2.8 7.2 7.4 4 6.7 7.0 1.4 1 1 0 1 1 1 0 FAM76 protein CENP-F_leu_zip PF10473.9 PIK49434.1 - 3.1 7.8 11.4 1.9 8.5 0.6 2.5 2 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MFS_1 PF07690.16 PIK49436.1 - 1.8e-29 102.8 18.2 1.9e-18 66.6 7.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK49436.1 - 5e-09 35.5 7.4 5e-09 35.5 7.4 2.3 1 1 2 3 3 3 1 MFS_1 like family MFS_4 PF06779.14 PIK49436.1 - 1.3e-06 28.0 7.5 0.0012 18.2 1.6 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB fn3 PF00041.21 PIK49437.1 - 2.1e-07 31.2 2.8 3.1e-07 30.6 0.2 2.4 2 1 0 2 2 2 1 Fibronectin type III domain DUF2015 PF09435.10 PIK49437.1 - 0.021 14.7 0.0 0.27 11.1 0.0 2.2 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) Pur_ac_phosph_N PF16656.5 PIK49437.1 - 1.4 9.5 6.3 0.19 12.3 0.7 2.4 2 2 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain PhoPQ_related PF10142.9 PIK49438.1 - 5.6e-47 160.2 10.3 1.6e-24 86.2 0.0 4.0 1 1 3 4 4 4 4 PhoPQ-activated pathogenicity-related protein PhoPQ_related PF10142.9 PIK49439.1 - 4.5e-112 374.3 0.0 5.2e-112 374.1 0.0 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein CTP_transf_3 PF02348.19 PIK49440.1 - 2.1e-20 73.6 0.0 2.7e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 PIK49440.1 - 0.13 12.6 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 MobA-like NTP transferase domain Ank_4 PF13637.6 PIK49442.1 - 4.5e-23 81.3 0.5 5.4e-11 42.8 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK49442.1 - 9.2e-19 67.8 0.2 3.1e-12 46.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK49442.1 - 6.9e-16 56.8 0.0 8.9e-05 22.6 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK49442.1 - 1.6e-13 50.6 0.2 3.1e-08 33.7 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK49442.1 - 5.8e-12 45.5 0.1 0.0009 19.6 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat SNF2_N PF00176.23 PIK49443.1 - 7.7e-62 209.0 0.7 7.7e-62 209.0 0.7 2.8 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK49443.1 - 8.7e-22 77.6 0.7 2.8e-21 75.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CHRD PF07452.12 PIK49445.1 - 2.7e-29 102.5 0.0 2e-13 51.3 0.0 4.4 4 0 0 4 4 4 3 CHRD domain VWC PF00093.18 PIK49445.1 - 1.1e-24 86.5 58.8 4.7e-10 39.6 13.4 4.7 4 1 0 4 4 4 4 von Willebrand factor type C domain Amnionless PF14828.6 PIK49445.1 - 4.8 5.9 62.0 0.15 10.9 6.4 4.2 4 0 0 4 4 4 0 Amnionless AAA PF00004.29 PIK49446.1 - 4.6e-29 101.5 0.0 5.9e-28 97.9 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK49446.1 - 0.001 19.5 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK49446.1 - 0.0028 18.0 0.0 0.0067 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK49446.1 - 0.0033 17.4 0.1 0.016 15.2 0.0 2.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 PIK49446.1 - 0.015 15.1 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 PIK49446.1 - 0.017 14.3 0.0 0.034 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 PIK49446.1 - 0.017 14.9 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 PIK49446.1 - 0.017 15.7 0.0 0.033 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 PIK49446.1 - 0.017 15.3 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 PIK49446.1 - 0.018 15.3 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK49446.1 - 0.037 14.4 0.0 0.23 11.9 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 PIK49446.1 - 0.051 13.1 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 PIK49446.1 - 0.065 12.4 0.1 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain Mg_chelatase PF01078.21 PIK49446.1 - 0.072 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_lid_3 PF17862.1 PIK49446.1 - 0.094 12.5 0.1 0.36 10.7 0.1 2.0 2 0 0 2 2 2 0 AAA+ lid domain AAA_3 PF07726.11 PIK49446.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 PIK49446.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 PIK49446.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 PIK49446.1 - 0.2 11.4 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 PIK49447.1 - 6.2e-14 52.7 0.0 1.6e-13 51.3 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 PIK49447.1 - 2.5e-07 30.4 0.1 3.2e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 PIK49447.1 - 7.8e-05 21.7 0.0 0.00011 21.2 0.0 1.3 1 1 0 1 1 1 1 Predicted ATPase of the ABC class SbcCD_C PF13558.6 PIK49447.1 - 0.005 17.0 0.7 0.1 12.9 0.7 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Phage_T4_Ndd PF06591.11 PIK49447.1 - 0.0077 16.0 0.1 0.015 15.0 0.0 1.5 2 0 0 2 2 2 1 T4-like phage nuclear disruption protein (Ndd) AAA PF00004.29 PIK49447.1 - 0.075 13.5 0.0 0.097 13.1 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_membrane PF00664.23 PIK49448.1 - 2e-114 381.9 2.3 7.8e-69 232.4 0.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 PIK49448.1 - 1.7e-55 187.3 1.2 1.4e-34 119.5 0.0 3.2 3 0 0 3 3 3 2 ABC transporter RsgA_GTPase PF03193.16 PIK49448.1 - 2.5e-10 40.5 0.2 0.00028 20.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 PIK49448.1 - 1.5e-08 35.2 2.1 0.0039 17.6 0.4 3.0 2 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 PIK49448.1 - 3.5e-08 33.2 2.7 3.7e-05 23.3 0.1 3.1 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 PIK49448.1 - 1.4e-07 31.8 0.2 0.015 15.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 PIK49448.1 - 6.9e-07 28.9 0.5 0.042 13.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_7 PF12775.7 PIK49448.1 - 3.9e-06 26.5 0.0 0.047 13.2 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 PIK49448.1 - 7.6e-06 26.4 0.0 0.48 10.9 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK49448.1 - 1.2e-05 24.7 0.2 0.074 12.3 0.0 2.6 3 0 0 3 3 3 2 Zeta toxin AAA_15 PF13175.6 PIK49448.1 - 1.7e-05 24.8 0.1 0.13 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 PIK49448.1 - 6.4e-05 23.0 0.1 0.32 11.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 PIK49448.1 - 8.5e-05 22.4 0.0 0.45 10.2 0.0 3.0 3 0 0 3 3 3 2 AAA domain G-alpha PF00503.20 PIK49448.1 - 9.3e-05 21.7 1.0 0.061 12.5 0.0 2.7 3 0 0 3 3 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK49448.1 - 0.00013 22.0 1.2 0.48 10.5 0.0 3.2 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 PIK49448.1 - 0.00018 21.5 0.1 0.66 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 PIK49448.1 - 0.00042 20.1 0.1 0.8 9.4 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 PIK49448.1 - 0.00047 20.7 0.3 1.5 9.3 0.1 3.2 3 0 0 3 3 3 1 AAA domain APS_kinase PF01583.20 PIK49448.1 - 0.00051 20.0 0.8 0.2 11.6 0.0 3.0 3 0 0 3 3 2 1 Adenylylsulphate kinase NB-ARC PF00931.22 PIK49448.1 - 0.00055 19.2 0.1 1 8.5 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain ATP-synt_ab PF00006.25 PIK49448.1 - 0.0007 19.3 0.1 0.6 9.7 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 PIK49448.1 - 0.00081 18.6 0.1 1.2 8.2 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Rad17 PF03215.15 PIK49448.1 - 0.00087 19.3 0.1 1.7 8.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_25 PF13481.6 PIK49448.1 - 0.0012 18.5 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 PIK49448.1 - 0.0016 18.8 0.1 3.1 8.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 PIK49448.1 - 0.0016 18.4 0.1 0.72 9.8 0.0 2.8 2 0 0 2 2 2 1 NACHT domain DUF2207 PF09972.9 PIK49448.1 - 0.0024 16.7 8.9 0.0087 14.9 0.0 3.4 3 1 0 3 3 3 1 Predicted membrane protein (DUF2207) KAP_NTPase PF07693.14 PIK49448.1 - 0.0035 16.6 2.5 7 5.8 0.0 3.4 2 1 0 3 3 3 0 KAP family P-loop domain FeoB_N PF02421.18 PIK49448.1 - 0.0042 16.6 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_18 PF13238.6 PIK49448.1 - 0.0071 16.9 0.1 7.1 7.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 PIK49448.1 - 0.008 15.9 0.2 2.5 7.8 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 PIK49448.1 - 0.011 16.0 1.2 5.5 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 PIK49448.1 - 0.012 15.3 0.1 15 5.3 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein Septin PF00735.18 PIK49448.1 - 0.021 14.1 0.3 6 6.1 0.0 2.3 2 0 0 2 2 2 0 Septin ABC_ATPase PF09818.9 PIK49448.1 - 0.037 12.8 0.0 0.037 12.8 0.0 2.4 4 0 0 4 4 3 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 PIK49448.1 - 0.039 14.1 0.0 9.4 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 PIK49448.1 - 0.058 13.4 0.1 11 6.0 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 PIK49448.1 - 0.071 13.3 0.4 13 6.1 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 PIK49448.1 - 0.074 13.1 2.8 5.3 7.1 0.1 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain NTPase_1 PF03266.15 PIK49448.1 - 0.086 12.7 0.1 13 5.6 0.0 2.4 2 0 0 2 2 2 0 NTPase Ras PF00071.22 PIK49448.1 - 0.11 12.1 0.9 11 5.6 0.1 2.8 3 0 0 3 3 2 0 Ras family AAA_10 PF12846.7 PIK49448.1 - 0.19 10.6 0.5 10 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain Glyco_transf_8 PF01501.20 PIK49449.1 - 7.5e-43 146.9 0.2 7.5e-43 146.9 0.2 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 PIK49449.1 - 8.2e-07 28.7 0.1 1.4e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 DUF4330 PF14221.6 PIK49449.1 - 0.072 13.3 1.0 0.11 12.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) tRNA_synthFbeta PF17759.1 PIK49450.1 - 2.7e-48 164.2 0.0 4.1e-48 163.6 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 PIK49450.1 - 1.1e-33 115.3 0.1 2.9e-33 113.9 0.1 1.8 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 PIK49450.1 - 3.5e-28 98.4 0.1 5.8e-28 97.7 0.1 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 PIK49450.1 - 3.7e-06 27.1 0.2 0.0088 16.3 0.1 3.3 3 0 0 3 3 3 2 tRNA synthetase B5 domain SH3BP5 PF05276.14 PIK49451.1 - 1.9e-74 250.4 22.9 2.4e-74 250.0 22.9 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF2333 PF10095.9 PIK49451.1 - 0.84 8.6 5.6 1 8.3 1.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2333) SH3BP5 PF05276.14 PIK49452.1 - 4.7e-14 52.8 7.0 6e-14 52.4 7.0 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) SH3BP5 PF05276.14 PIK49453.1 - 2.5e-09 37.3 0.2 2.8e-09 37.1 0.2 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) Dishevelled PF02377.15 PIK49454.1 - 4e-49 167.2 24.0 4e-49 167.2 24.0 2.9 3 0 0 3 3 3 1 Dishevelled specific domain PDZ PF00595.24 PIK49454.1 - 2.9e-19 69.2 1.1 5.3e-19 68.4 1.1 1.4 1 0 0 1 1 1 1 PDZ domain DEP PF00610.21 PIK49454.1 - 5.1e-15 55.3 0.1 1.1e-14 54.3 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dsh_C PF12316.8 PIK49454.1 - 4.6e-08 33.7 21.7 2e-07 31.6 10.6 3.8 3 2 1 4 4 4 2 Segment polarity protein dishevelled (Dsh) C terminal PDZ_6 PF17820.1 PIK49454.1 - 5.4e-06 26.2 0.2 1e-05 25.3 0.2 1.4 1 0 0 1 1 1 1 PDZ domain DIX PF00778.17 PIK49454.1 - 5.6e-05 22.9 0.1 0.00011 22.0 0.1 1.5 1 0 0 1 1 1 1 DIX domain PDZ_2 PF13180.6 PIK49454.1 - 0.00046 20.4 0.2 0.00087 19.6 0.2 1.4 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 PIK49455.1 - 1.1e-25 90.4 0.3 1.5e-25 89.9 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49455.1 - 4.2e-19 69.0 0.2 6.4e-19 68.3 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF2111 PF09884.9 PIK49455.1 - 0.073 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2111) Death PF00531.22 PIK49457.1 - 1.1e-13 51.1 0.9 4.1e-13 49.3 0.3 2.0 2 0 0 2 2 2 1 Death domain IF-2B PF01008.17 PIK49458.1 - 9e-08 31.7 0.0 1.1e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Kelch_5 PF13854.6 PIK49459.1 - 6.1e-16 58.0 27.7 0.00023 21.1 0.1 7.4 7 0 0 7 7 7 6 Kelch motif Kelch_4 PF13418.6 PIK49459.1 - 9.6e-15 54.3 12.4 0.0025 17.8 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK49459.1 - 4.6e-13 48.9 30.3 0.00015 21.9 0.2 8.0 7 1 1 8 8 8 4 Kelch motif Kelch_1 PF01344.25 PIK49459.1 - 7.2e-12 44.7 18.8 0.00082 18.9 0.3 7.4 7 1 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 PIK49459.1 - 4.4e-11 42.3 15.1 0.00016 21.5 0.1 6.7 7 0 0 7 7 7 3 Kelch motif PSI PF01437.25 PIK49459.1 - 3.4e-07 30.7 32.6 5.5e-05 23.6 15.5 7.4 4 2 2 6 6 6 5 Plexin repeat Kelch_3 PF13415.6 PIK49459.1 - 5.7e-06 26.5 17.2 0.17 12.2 0.0 6.9 7 0 0 7 7 7 3 Galactose oxidase, central domain Paramecium_SA PF01508.16 PIK49459.1 - 0.0026 18.2 1.1 0.0026 18.2 1.1 6.6 4 2 2 6 6 6 1 Paramecium surface antigen domain HemY_N PF07219.13 PIK49459.1 - 0.33 11.2 2.4 0.56 10.4 2.4 1.2 1 0 0 1 1 1 0 HemY protein N-terminus PetM PF08041.11 PIK49459.1 - 7.8 6.2 7.1 15 5.2 7.1 1.5 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 DJ-1_PfpI PF01965.24 PIK49460.1 - 2.5e-05 24.2 0.2 7.4e-05 22.6 0.1 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family Acetyltransf_1 PF00583.25 PIK49461.1 - 9.3e-09 35.5 0.0 1.7e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK49461.1 - 2.3e-07 30.8 0.0 3.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK49461.1 - 4.5e-06 27.0 0.0 6.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 PIK49461.1 - 0.0023 18.0 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 PIK49461.1 - 0.019 15.7 0.0 0.035 14.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 PIK49461.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK49462.1 - 7e-06 26.3 0.0 1.2e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK49462.1 - 0.00033 20.6 0.0 0.00048 20.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK49462.1 - 0.0016 18.8 0.0 0.0028 18.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CLAMP PF14769.6 PIK49463.1 - 5.7e-14 52.4 0.0 1e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 BACK PF07707.15 PIK49464.1 - 0.024 14.7 0.2 0.27 11.4 0.0 2.5 2 0 0 2 2 2 0 BTB And C-terminal Kelch BTB PF00651.31 PIK49464.1 - 0.032 14.4 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 BTB/POZ domain EABR PF12180.8 PIK49466.1 - 0.0077 15.8 1.9 0.022 14.4 1.9 1.8 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 ThiD2 PF17792.1 PIK49466.1 - 4.2 7.8 8.9 0.3 11.5 2.1 2.1 2 0 0 2 2 2 0 ThiD2 family 2-Hacid_dh_C PF02826.19 PIK49467.1 - 4.5e-58 195.5 0.0 6.3e-58 195.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK49467.1 - 8.9e-27 93.4 0.0 1.2e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 PIK49467.1 - 2.9e-05 24.3 0.0 5.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase PseudoU_synth_1 PF01416.20 PIK49468.1 - 8.7e-15 55.1 0.0 3.8e-13 49.9 0.0 2.7 3 0 0 3 3 3 1 tRNA pseudouridine synthase RNA_pol_Rpc82 PF05645.13 PIK49468.1 - 0.66 9.7 7.9 1.6 8.4 7.9 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 O-antigen_lig PF13425.6 PIK49468.1 - 1.1 8.0 0.0 1.1 8.0 0.0 2.2 2 0 0 2 2 2 0 O-antigen ligase like membrane protein HSP20 PF00011.21 PIK49469.1 - 2.4e-17 63.0 0.2 3.9e-17 62.3 0.2 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family HSP20 PF00011.21 PIK49470.1 - 2.3e-19 69.4 0.3 4.5e-19 68.5 0.3 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 PIK49470.1 - 0.0061 16.1 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 PIK49470.1 - 0.097 13.7 0.4 0.5 11.4 0.1 2.0 2 0 0 2 2 2 0 CS domain HSP20 PF00011.21 PIK49471.1 - 1.7e-15 57.0 0.1 3.2e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ARID PF01388.21 PIK49472.1 - 4.5e-17 62.5 0.0 1.3e-16 61.0 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C4H2 PF10146.9 PIK49473.1 - 0.0075 16.6 9.1 0.0075 16.6 9.1 1.7 2 1 0 2 2 2 1 Zinc finger-containing protein Seryl_tRNA_N PF02403.22 PIK49473.1 - 0.026 14.8 7.1 0.026 14.8 7.1 3.4 4 1 1 5 5 5 0 Seryl-tRNA synthetase N-terminal domain PEPcase PF00311.17 PIK49473.1 - 0.13 10.3 6.8 0.19 9.8 6.8 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase ParB PF08775.10 PIK49473.1 - 0.33 11.4 5.5 1.1 9.8 5.5 1.9 1 0 0 1 1 1 0 ParB family Pox_A_type_inc PF04508.12 PIK49473.1 - 0.53 10.2 0.1 0.53 10.2 0.1 3.9 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat RPA_interact_M PF14767.6 PIK49473.1 - 0.8 10.3 9.1 3.5 8.3 4.3 3.4 2 1 0 2 2 2 0 Replication protein A interacting middle Snapin_Pallidin PF14712.6 PIK49473.1 - 3.3 8.2 16.4 0.097 13.1 7.8 2.7 3 0 0 3 3 3 0 Snapin/Pallidin DUF4407 PF14362.6 PIK49473.1 - 3.6 6.8 13.1 0.58 9.4 9.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) GvpL_GvpF PF06386.11 PIK49473.1 - 5.5 6.8 11.9 17 5.3 11.8 1.7 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Exo_endo_phos PF03372.23 PIK49474.1 - 2.8e-15 56.5 0.0 1.2e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Enolase_C PF00113.22 PIK49475.1 - 9.7e-46 156.3 0.0 1.9e-45 155.4 0.0 1.4 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 PIK49475.1 - 1.5e-15 57.5 0.1 2.1e-09 37.6 0.1 2.3 2 0 0 2 2 2 2 Enolase, N-terminal domain Tma16 PF11176.8 PIK49475.1 - 0.11 12.4 0.4 0.21 11.5 0.4 1.4 1 0 0 1 1 1 0 Translation machinery-associated protein 16 bZIP_1 PF00170.21 PIK49475.1 - 1.6 8.9 7.2 0.58 10.3 0.4 2.7 3 0 0 3 3 3 0 bZIP transcription factor Ank_2 PF12796.7 PIK49476.1 - 8.6e-19 67.9 0.6 7.5e-11 42.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK49476.1 - 1e-14 54.7 4.2 1.2e-08 35.3 0.6 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK49476.1 - 9.9e-14 51.2 0.4 4.1e-07 30.1 0.1 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK49476.1 - 3.8e-10 39.8 3.4 0.034 14.6 0.2 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 PIK49476.1 - 4.7e-10 38.8 1.5 0.002 18.5 0.3 3.5 3 0 0 3 3 3 3 Ankyrin repeat Erv26 PF04148.13 PIK49477.1 - 1.5e-51 175.2 23.7 4.4e-51 173.6 23.7 1.6 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 IRS PF02174.17 PIK49478.1 - 4.9e-23 80.9 0.0 1.2e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Pkinase PF00069.25 PIK49479.1 - 3e-11 43.2 0.0 3.4e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49479.1 - 3.2e-05 23.4 0.0 3.6e-05 23.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 PIK49479.1 - 0.011 14.7 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase HLH PF00010.26 PIK49480.1 - 2.7e-14 52.9 2.5 4.9e-14 52.0 2.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2989 PF11207.8 PIK49480.1 - 0.0039 17.0 0.6 0.012 15.4 0.3 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2989) MCM_bind PF09739.9 PIK49481.1 - 1e-158 529.5 1.7 1.2e-158 529.2 1.7 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Defensin_4 PF07936.12 PIK49481.1 - 0.039 13.8 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 Potassium-channel blocking toxin ATP-cone PF03477.16 PIK49481.1 - 0.11 13.1 0.1 0.3 11.7 0.1 1.7 1 0 0 1 1 1 0 ATP cone domain MCM_bind PF09739.9 PIK49482.1 - 7.8e-42 143.5 0.2 8.7e-42 143.3 0.2 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Peptidase_M16 PF00675.20 PIK49483.1 - 1.2e-16 61.1 0.1 1.3e-16 60.9 0.1 1.0 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) SMI1_KNR4 PF09346.10 PIK49483.1 - 0.09 13.2 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Peptidase_M16_M PF16187.5 PIK49484.1 - 8.9e-98 327.0 2.7 2.1e-97 325.8 0.8 2.1 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 PIK49484.1 - 6.3e-27 94.8 0.3 1.6e-11 44.5 0.1 3.6 3 1 0 3 3 3 2 Peptidase M16 inactive domain Arg_tRNA_synt_N PF03485.16 PIK49484.1 - 0.099 13.2 0.0 13 6.4 0.0 2.7 2 0 0 2 2 2 0 Arginyl tRNA synthetase N terminal domain DUF2779 PF11074.8 PIK49484.1 - 0.4 11.1 3.7 2.6 8.5 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function(DUF2779) RINGv PF12906.7 PIK49485.1 - 3e-14 52.9 10.8 4.5e-14 52.3 10.8 1.3 1 0 0 1 1 1 1 RING-variant domain zinc_ribbon_4 PF13717.6 PIK49485.1 - 0.0082 16.0 0.2 0.021 14.8 0.2 1.7 1 0 0 1 1 1 1 zinc-ribbon domain zf-RING_2 PF13639.6 PIK49485.1 - 0.012 15.9 6.0 0.027 14.8 6.0 1.7 1 0 0 1 1 1 0 Ring finger domain Phage_holin_2_3 PF16080.5 PIK49485.1 - 0.04 13.7 0.2 0.1 12.4 0.2 1.7 1 1 0 1 1 1 0 Bacteriophage holin family HP1 zf-CSL PF05207.13 PIK49485.1 - 0.093 12.5 2.5 1.8 8.4 3.2 2.1 1 1 1 2 2 2 0 CSL zinc finger FANCL_C PF11793.8 PIK49485.1 - 0.096 12.9 6.0 0.17 12.1 6.0 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C2H2_3 PF13878.6 PIK49485.1 - 0.13 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO zinc_ribbon_5 PF13719.6 PIK49485.1 - 0.34 10.7 2.7 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain PHD PF00628.29 PIK49485.1 - 1.7 8.6 8.5 2.9 7.8 8.5 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 PIK49485.1 - 2 8.3 7.0 1.8 8.5 5.5 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RRM_7 PF16367.5 PIK49486.1 - 2.3e-37 127.0 0.0 2.6e-35 120.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 PIK49486.1 - 2.7e-20 72.3 5.7 5.1e-20 71.5 5.7 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 PIK49486.1 - 3.2e-11 42.9 0.0 5.4e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-B_box PF00643.24 PIK49486.1 - 0.58 10.3 6.5 1.1 9.4 6.5 1.4 1 0 0 1 1 1 0 B-box zinc finger MMR_HSR1 PF01926.23 PIK49487.1 - 7.3e-06 26.1 0.2 0.00013 22.1 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 PIK49487.1 - 0.00082 19.0 0.1 0.51 9.9 0.0 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK49487.1 - 0.02 15.1 0.1 0.38 11.0 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK49487.1 - 0.02 14.4 0.1 0.22 11.0 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK49487.1 - 0.029 14.3 0.1 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase CENP-I PF07778.11 PIK49487.1 - 0.076 11.7 0.1 1.5 7.4 0.1 2.2 1 1 0 2 2 2 0 Mis6 Dynamin_N PF00350.23 PIK49487.1 - 0.086 12.9 0.1 0.3 11.1 0.1 1.9 1 1 0 1 1 1 0 Dynamin family SRPRB PF09439.10 PIK49487.1 - 0.097 12.1 0.1 0.21 11.0 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit CTP_transf_like PF01467.26 PIK49488.1 - 5.6e-09 36.3 0.0 4e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like Melibiase_C PF17801.1 PIK49488.1 - 0.049 13.7 0.0 0.34 11.0 0.0 2.1 2 1 0 2 2 2 0 Alpha galactosidase C-terminal beta sandwich domain Hydrolase_4 PF12146.8 PIK49489.1 - 0.0031 16.8 0.0 0.085 12.1 0.0 2.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK49489.1 - 0.023 15.3 0.0 0.051 14.2 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 PIK49489.1 - 0.16 12.1 0.0 0.45 10.6 0.0 1.7 1 0 0 1 1 1 0 Thioesterase domain DLH PF01738.18 PIK49489.1 - 0.2 11.2 0.0 0.43 10.1 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family HLH PF00010.26 PIK49490.1 - 1.6e-14 53.5 0.2 1.6e-14 53.5 0.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Pkinase PF00069.25 PIK49491.1 - 1.4e-14 54.1 0.0 1.6e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49491.1 - 3.9e-06 26.3 0.0 4.4e-06 26.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Phage_int_SAM_4 PF13495.6 PIK49494.1 - 0.00017 22.0 0.0 0.00037 20.9 0.0 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK49494.1 - 0.00036 20.8 0.3 0.00036 20.8 0.3 1.8 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain IRK_C PF17655.1 PIK49495.1 - 1.2e-48 165.1 0.0 1.7e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK_C PF17655.1 PIK49496.1 - 1.9e-55 187.1 0.0 2.7e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 PIK49496.1 - 4.5e-44 149.7 0.3 6.7e-44 149.1 0.3 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 PIK49496.1 - 0.0004 20.3 3.4 0.00087 19.2 2.6 1.9 1 1 1 2 2 2 2 Ion channel Ras PF00071.22 PIK49497.1 - 4e-41 140.3 0.0 4.7e-41 140.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK49497.1 - 2.4e-16 60.0 0.0 3.7e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK49497.1 - 6.3e-05 22.3 0.1 8.1e-05 21.9 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK49497.1 - 9.7e-05 21.9 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK49497.1 - 0.0022 17.9 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 PIK49497.1 - 0.029 13.9 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain WD40 PF00400.32 PIK49498.1 - 6.9e-37 124.8 7.0 3.9e-05 24.3 0.2 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49498.1 - 2.8e-12 46.8 1.7 0.00015 22.0 0.2 5.2 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK49498.1 - 1.1e-06 27.9 0.6 0.28 10.1 0.0 4.7 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK49498.1 - 1.5e-05 25.0 2.1 0.45 10.4 0.4 3.7 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK49498.1 - 0.00032 19.5 1.9 0.23 10.0 0.2 3.3 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Hira PF07569.11 PIK49498.1 - 0.00078 19.2 0.4 1.2 8.8 0.0 3.4 2 1 2 4 4 4 2 TUP1-like enhancer of split HPS3_N PF14761.6 PIK49498.1 - 0.0039 16.8 0.1 1.7 8.1 0.0 3.0 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 Frtz PF11768.8 PIK49498.1 - 0.076 11.3 0.0 0.1 10.9 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz ParE-like_toxin PF15781.5 PIK49498.1 - 0.2 11.6 0.0 0.52 10.3 0.0 1.6 1 0 0 1 1 1 0 ParE-like toxin of type II bacterial toxin-antitoxin system USP7_ICP0_bdg PF12436.8 PIK49499.1 - 3.7e-56 190.1 0.5 1.7e-55 188.0 0.0 2.3 2 1 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 PIK49499.1 - 5.3e-55 186.3 1.6 1e-54 185.4 1.6 1.5 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 PIK49499.1 - 1.8e-28 99.7 0.6 4e-28 98.6 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 PIK49499.1 - 4.8e-20 71.8 0.2 2.4e-19 69.5 0.2 2.2 2 0 0 2 2 2 1 MATH domain UCH_1 PF13423.6 PIK49499.1 - 8.1e-14 51.9 2.9 1.9e-13 50.7 2.9 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Il2rg PF15874.5 PIK49499.1 - 0.12 12.6 0.1 1.7 9.0 0.1 2.5 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain Acetyltransf_1 PF00583.25 PIK49500.1 - 0.0011 19.2 0.0 0.0012 19.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_17 PF17668.1 PIK49500.1 - 0.053 14.3 0.0 0.065 14.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK49500.1 - 0.16 12.4 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RVT_1 PF00078.27 PIK49501.1 - 1.9e-13 50.5 0.0 2.2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_4 PF13359.6 PIK49502.1 - 1.5e-31 109.2 0.0 3.7e-31 107.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Flexi_CP PF00286.20 PIK49502.1 - 0.024 14.6 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Viral coat protein NLRC4_HD2 PF17776.1 PIK49502.1 - 0.072 13.6 0.2 0.18 12.3 0.2 1.6 1 0 0 1 1 1 0 NLRC4 helical domain HD2 zf-Di19 PF05605.12 PIK49503.1 - 0.032 14.5 0.3 0.084 13.2 0.3 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK49503.1 - 0.071 12.9 1.7 0.23 11.3 1.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc-finger domain YusW PF14039.6 PIK49504.1 - 0.00085 19.8 3.9 0.1 13.1 0.5 2.3 2 0 0 2 2 2 2 YusW-like protein Peptidase_A17 PF05380.13 PIK49505.1 - 2.8e-40 138.0 1.1 3.5e-40 137.7 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK49505.1 - 1.6e-05 24.9 0.9 1.6e-05 24.9 0.9 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain DUF1759 PF03564.15 PIK49506.1 - 1.4e-07 31.5 0.1 2.3e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK49506.1 - 0.32 11.6 3.0 0.34 11.5 0.1 2.3 3 0 0 3 3 3 0 Tis11B like protein, N terminus DUF753 PF05444.12 PIK49506.1 - 6.3 6.8 8.2 1.2 9.2 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF753) Roc PF08477.13 PIK49507.1 - 6.8e-11 42.4 0.0 9.6e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK49507.1 - 1.9e-06 27.6 0.0 2.5e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 PIK49507.1 - 0.0018 17.7 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK49507.1 - 0.029 14.4 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 PIK49507.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit SR-25 PF10500.9 PIK49508.1 - 0.0024 17.6 23.1 0.0028 17.3 21.7 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein GAGA_bind PF06217.12 PIK49508.1 - 0.035 14.4 10.9 0.036 14.3 10.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Endostatin PF06482.11 PIK49508.1 - 1.7 8.1 5.2 2 7.8 5.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MMU163 PF17119.5 PIK49508.1 - 3.4 6.7 10.4 4.6 6.3 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Presenilin PF01080.17 PIK49508.1 - 3.8 6.2 11.1 4.1 6.1 11.1 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 PIK49508.1 - 8.3 5.3 7.7 9.5 5.1 7.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 PIK49508.1 - 8.7 5.5 13.4 11 5.2 13.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF2052 PF09747.9 PIK49508.1 - 9.1 6.4 21.7 4.5 7.4 19.6 1.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 PIK49508.1 - 9.6 4.4 16.1 9.9 4.3 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein C2 PF00168.30 PIK49509.1 - 3.6e-11 43.3 0.0 8.9e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain C2 PF00168.30 PIK49510.1 - 2.3e-06 27.8 0.0 0.052 13.8 0.0 3.2 2 0 0 2 2 2 2 C2 domain Membr_traf_MHD PF10540.9 PIK49510.1 - 0.12 12.5 1.5 0.2 11.8 0.1 2.2 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain CDC37_M PF08565.11 PIK49510.1 - 0.19 11.7 1.5 4.1 7.4 0.1 3.5 3 1 1 4 4 4 0 Cdc37 Hsp90 binding domain DUF489 PF04356.12 PIK49510.1 - 0.19 11.7 1.6 0.77 9.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Pkinase PF00069.25 PIK49511.1 - 2.8e-57 194.1 0.0 3.4e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49511.1 - 3.5e-30 105.2 0.0 4.5e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK49511.1 - 0.00028 19.9 0.0 0.00038 19.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 PIK49511.1 - 0.00055 18.8 0.0 0.00079 18.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK49511.1 - 0.0055 16.0 0.0 0.014 14.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK49511.1 - 0.015 15.2 0.1 0.042 13.8 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 PIK49511.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Lectin_C PF00059.21 PIK49512.1 - 1.7e-09 38.4 0.9 3.7e-09 37.3 0.9 1.6 1 0 0 1 1 1 1 Lectin C-type domain GPS PF01825.21 PIK49513.1 - 3.2e-16 59.6 3.4 9.8e-16 58.0 3.4 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK49513.1 - 9.4e-09 34.9 4.4 2e-07 30.5 0.1 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 PIK49513.1 - 0.21 10.7 3.0 3 6.9 0.6 2.1 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor EamA PF00892.20 PIK49514.1 - 3.1e-11 43.6 9.6 3.1e-11 43.6 9.6 1.8 2 0 0 2 2 2 1 EamA-like transporter family DUF2070 PF09843.9 PIK49514.1 - 9.9 4.3 9.2 5.6 5.1 3.9 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) NUDIX PF00293.28 PIK49515.1 - 0.0027 17.7 0.2 0.0043 17.1 0.2 1.5 1 1 0 1 1 1 1 NUDIX domain Nudix_hydro PF18290.1 PIK49516.1 - 2e-20 72.5 0.9 3.4e-20 71.8 0.9 1.4 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 PIK49516.1 - 1.8e-15 57.1 0.0 6.1e-15 55.4 0.0 1.7 1 1 1 2 2 2 1 NUDIX domain Guanylate_cyc_2 PF09778.9 PIK49517.1 - 1.9e-46 158.1 0.6 2.4e-46 157.8 0.6 1.0 1 0 0 1 1 1 1 Guanylylate cyclase DUF3335 PF11814.8 PIK49517.1 - 0.00091 18.8 0.8 0.0072 15.8 0.7 2.1 1 1 0 1 1 1 1 Peptidase_C39 like family Cys_rich_CPXG PF14255.6 PIK49517.1 - 0.034 14.0 1.8 0.075 12.9 0.2 2.1 2 0 0 2 2 2 0 Cysteine-rich CPXCG Peptidase_C39 PF03412.15 PIK49517.1 - 0.068 13.0 0.0 0.5 10.2 0.0 2.1 2 0 0 2 2 2 0 Peptidase C39 family DUF359 PF04019.12 PIK49517.1 - 0.073 12.7 0.2 0.14 11.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF359) Peptidase_C39_2 PF13529.6 PIK49517.1 - 0.14 12.7 0.1 0.95 10.0 0.1 2.3 1 1 0 1 1 1 0 Peptidase_C39 like family dCache_2 PF08269.11 PIK49518.1 - 0.095 11.9 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Cache domain TPMT PF05724.11 PIK49519.1 - 1.9e-42 145.4 0.0 2.3e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Trypsin PF00089.26 PIK49520.1 - 3.7e-69 232.9 1.7 7.2e-69 232.0 1.7 1.5 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK49520.1 - 9.8e-54 179.3 136.0 3.1e-11 43.3 15.2 7.0 7 0 0 7 7 7 6 Low-density lipoprotein receptor domain class A Ycf1 PF05758.12 PIK49520.1 - 0.38 8.6 4.7 0.48 8.2 4.7 1.1 1 0 0 1 1 1 0 Ycf1 DUF4228 PF14009.6 PIK49520.1 - 3.3 8.0 14.7 5.2 7.4 4.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Neur_chan_memb PF02932.16 PIK49520.1 - 3.6 7.6 9.5 0.61 10.1 1.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 PIK49520.1 - 3.8 7.6 10.9 1.5 8.9 2.3 2.2 2 0 0 2 2 2 0 DDHD domain DUF4407 PF14362.6 PIK49520.1 - 3.9 6.7 6.5 5.9 6.2 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sugar_tr PF00083.24 PIK49521.1 - 1.9e-15 56.7 4.7 2.2e-15 56.5 4.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK49521.1 - 1.6e-10 40.4 12.2 2e-10 40.2 12.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Gate PF07670.14 PIK49521.1 - 1.1 9.6 7.3 0.86 9.9 4.2 2.2 1 1 1 2 2 2 0 Nucleoside recognition DUF3147 PF11345.8 PIK49521.1 - 2.6 8.4 10.0 0.19 12.1 0.8 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3147) C2-set_2 PF08205.12 PIK49522.1 - 0.018 15.1 1.1 4.1 7.5 0.3 3.3 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK49523.1 - 0.0013 18.9 1.5 0.0021 18.2 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK49523.1 - 0.031 14.3 1.1 8 6.6 0.1 3.2 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain DUF4198 PF10670.9 PIK49524.1 - 0.078 13.3 0.0 0.093 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Albumin_I PF08027.11 PIK49524.1 - 0.11 12.2 0.8 0.34 10.6 0.8 1.8 1 0 0 1 1 1 0 Albumin I chain b IDO PF01231.18 PIK49525.1 - 0.025 13.4 0.1 0.041 12.7 0.1 1.2 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase NRDE-2 PF08424.10 PIK49525.1 - 0.074 12.2 0.2 0.12 11.5 0.1 1.5 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference Pkinase_Tyr PF07714.17 PIK49527.1 - 4.1e-10 39.4 0.6 6.1e-10 38.8 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49527.1 - 0.00026 20.4 0.5 0.00045 19.7 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Ig_6 PF18452.1 PIK49527.1 - 0.019 14.6 0.0 0.05 13.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain TraA PF05513.11 PIK49527.1 - 0.031 14.6 0.3 0.12 12.8 0.4 1.9 1 1 1 2 2 2 0 TraA ig PF00047.25 PIK49527.1 - 0.2 11.8 3.0 26 5.1 0.0 3.4 3 1 0 3 3 3 0 Immunoglobulin domain V-set PF07686.17 PIK49527.1 - 1 9.5 4.7 1.1 9.4 0.0 3.2 4 2 0 4 4 4 0 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK49528.1 - 4.3e-27 95.0 0.0 6.6e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49528.1 - 1.5e-06 27.8 0.0 1.3e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Ig_3 PF13927.6 PIK49528.1 - 2.4e-06 28.0 3.0 0.028 15.0 0.3 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK49528.1 - 6e-06 26.2 0.1 0.029 14.4 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK49528.1 - 0.00038 20.7 2.2 0.17 12.3 0.3 2.7 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK49528.1 - 0.0018 18.3 0.5 0.0096 16.0 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK49528.1 - 0.033 14.3 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK49528.1 - 0.079 12.5 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK49528.1 - 0.081 13.1 1.1 0.52 10.5 0.0 2.6 2 1 0 3 3 3 0 Immunoglobulin V-set domain DUF223 PF02721.14 PIK49529.1 - 0.035 14.4 0.1 0.094 13.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF223 ZU5 PF00791.20 PIK49531.1 - 2.4e-09 37.4 0.0 6.9e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 ZU5 domain DUF3584 PF12128.8 PIK49531.1 - 0.0014 16.3 42.7 0.002 15.7 42.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ERM PF00769.19 PIK49531.1 - 0.82 9.4 65.3 0.64 9.8 11.7 2.8 1 1 2 3 3 3 0 Ezrin/radixin/moesin family GAS PF13851.6 PIK49531.1 - 0.82 9.0 58.6 0.58 9.5 16.9 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF150_C PF17384.2 PIK49531.1 - 0.97 9.6 5.4 5.8 7.1 0.2 3.7 2 1 1 3 3 3 0 RimP C-terminal SH3 domain AIM5 PF17050.5 PIK49532.1 - 0.024 15.4 1.1 0.8 10.6 0.1 2.4 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 RVT_1 PF00078.27 PIK49533.1 - 1.1e-17 64.3 0.0 4.9e-17 62.2 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) TrmB PF01978.19 PIK49533.1 - 0.13 12.2 0.1 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DED PF01335.21 PIK49534.1 - 0.00097 19.4 5.3 0.16 12.3 0.5 2.9 2 0 0 2 2 2 2 Death effector domain Pkinase_Tyr PF07714.17 PIK49535.1 - 3.3e-47 161.0 0.0 3.8e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49535.1 - 2.1e-15 56.8 0.0 2.7e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49537.1 - 1.6e-51 175.1 0.0 2.1e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49537.1 - 1.8e-19 70.2 0.0 2.2e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF2483 PF10656.9 PIK49537.1 - 0.058 13.6 0.3 0.23 11.7 0.0 2.0 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2483) NHL PF01436.21 PIK49538.1 - 0.012 15.7 0.0 8.1 6.7 0.0 4.3 5 0 0 5 5 5 0 NHL repeat SBBP PF06739.11 PIK49538.1 - 0.082 12.9 0.2 0.19 11.8 0.2 1.6 1 0 0 1 1 1 0 Beta-propeller repeat DUF1517 PF07466.11 PIK49538.1 - 0.13 12.4 0.3 0.22 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) V-SNARE PF05008.15 PIK49538.1 - 0.21 12.0 1.0 0.41 11.0 1.0 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus NHL PF01436.21 PIK49539.1 - 0.0027 17.6 0.0 12 6.2 0.0 4.4 5 0 0 5 5 5 2 NHL repeat DUF1517 PF07466.11 PIK49539.1 - 0.047 13.8 0.1 0.086 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) SBBP PF06739.11 PIK49539.1 - 0.1 12.6 0.2 0.26 11.3 0.2 1.7 1 0 0 1 1 1 0 Beta-propeller repeat RVT_1 PF00078.27 PIK49540.1 - 3.6e-26 92.1 0.0 4.9e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK49540.1 - 3.9e-06 26.8 0.0 7.8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK49540.1 - 0.012 15.9 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK49541.1 - 0.00017 21.2 0.0 0.00026 20.6 0.0 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VirB8 PF04335.13 PIK49542.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 VirB8 protein zf-C2H2_aberr PF17017.5 PIK49542.1 - 0.31 11.2 4.5 1.1 9.4 1.4 2.3 2 1 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 PIK49542.1 - 0.36 11.8 2.8 0.81 10.7 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger tRNA-synt_2d PF01409.20 PIK49543.1 - 0.038 13.5 0.2 4.9 6.6 0.0 2.6 2 1 1 3 3 3 0 tRNA synthetases class II core domain (F) Asp_protease_2 PF13650.6 PIK49544.1 - 0.08 13.6 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK49544.1 - 0.14 12.3 0.5 0.42 10.8 0.5 1.9 1 0 0 1 1 1 0 Zinc knuckle DUF5641 PF18701.1 PIK49545.1 - 8.9e-29 99.5 2.5 1.7e-28 98.6 2.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 PIK49545.1 - 5e-09 36.1 1.0 1.4e-08 34.7 1.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK49545.1 - 5.2e-05 23.4 0.0 0.00026 21.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK49545.1 - 0.002 18.3 0.1 0.0038 17.4 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger BssB_TutG PF18512.1 PIK49545.1 - 0.02 14.8 0.5 1.5 8.8 0.0 2.5 2 0 0 2 2 2 0 Benzylsuccinate synthase beta subunit Ribosomal_L37ae PF01780.19 PIK49546.1 - 5.8e-43 144.9 11.3 6.4e-43 144.7 11.3 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family CarbpepA_inh PF02977.15 PIK49546.1 - 0.019 14.8 4.9 0.047 13.5 4.9 1.7 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor Rsm1 PF08600.10 PIK49546.1 - 0.045 13.9 1.2 0.058 13.5 1.2 1.3 1 0 0 1 1 1 0 Rsm1-like Rep_fac-A_C PF08646.10 PIK49546.1 - 0.14 11.9 3.4 0.99 9.1 3.4 1.9 1 1 0 1 1 1 0 Replication factor-A C terminal domain DUF1451 PF07295.11 PIK49546.1 - 0.15 12.1 3.3 0.21 11.6 3.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn_Tnp_IS1595 PF12760.7 PIK49546.1 - 1.6 8.7 8.2 7 6.7 8.5 1.8 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF639 PF04842.12 PIK49548.1 - 0.036 13.5 0.3 0.065 12.6 0.3 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Reticulon PF02453.17 PIK49548.1 - 0.6 10.1 6.9 1.1 9.2 6.8 1.6 1 1 0 1 1 1 0 Reticulon Integrin_beta PF00362.18 PIK49549.1 - 4.4e-84 282.0 0.0 1.7e-77 260.4 0.0 2.3 1 1 1 2 2 2 2 Integrin beta chain VWA domain PSI_integrin PF17205.3 PIK49549.1 - 8.4e-12 44.6 9.0 8.4e-12 44.6 9.0 3.7 3 1 1 4 4 4 1 Integrin plexin domain Integrin_B_tail PF07965.12 PIK49549.1 - 9.3e-12 45.3 7.0 9.3e-12 45.3 7.0 3.9 3 1 1 4 4 4 1 Integrin beta tail domain I-EGF_1 PF18372.1 PIK49549.1 - 0.00015 21.8 4.2 0.00015 21.8 4.2 6.5 8 0 0 8 8 8 2 Integrin beta epidermal growth factor like domain 1 Integrin_b_cyt PF08725.11 PIK49549.1 - 0.00017 21.2 1.6 0.00031 20.4 1.6 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain EGF_2 PF07974.13 PIK49549.1 - 0.00086 19.6 7.3 0.00086 19.6 7.3 5.6 4 1 1 5 5 5 3 EGF-like domain LapA_dom PF06305.11 PIK49549.1 - 1.5 8.7 3.8 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Integrin_beta PF00362.18 PIK49550.1 - 1.4e-90 303.3 0.0 1.9e-90 302.9 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain EGF_2 PF07974.13 PIK49550.1 - 1.1e-05 25.7 87.3 0.065 13.6 10.4 6.1 3 2 3 6 6 6 4 EGF-like domain I-EGF_1 PF18372.1 PIK49550.1 - 8.5e-05 22.6 8.7 8.5e-05 22.6 8.7 6.5 7 0 0 7 7 7 2 Integrin beta epidermal growth factor like domain 1 STOP PF05217.12 PIK49550.1 - 0.033 14.5 2.2 0.033 14.5 2.2 6.1 7 1 0 7 7 7 0 STOP protein Vps54_N PF10475.9 PIK49551.1 - 1.7e-83 280.3 17.5 5.4e-83 278.6 17.5 1.8 1 1 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2524 PF10732.9 PIK49551.1 - 0.0043 17.3 2.7 0.041 14.2 0.3 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2524) DcpS_C PF11969.8 PIK49551.1 - 0.67 10.5 4.5 0.38 11.2 0.3 2.6 3 0 0 3 3 3 0 Scavenger mRNA decapping enzyme C-term binding Baculo_p24 PF05073.12 PIK49551.1 - 1 9.1 5.1 0.43 10.3 1.3 2.2 1 1 1 2 2 2 0 Baculovirus P24 capsid protein zf-C4pol PF14260.6 PIK49551.1 - 1.2 9.7 5.5 14 6.2 0.1 3.7 3 1 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta DUF2096 PF09869.9 PIK49551.1 - 3 7.9 6.0 4 7.5 0.6 2.9 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) DUF2451 PF10474.9 PIK49553.1 - 1.4e-51 175.6 1.2 2.1e-41 142.2 0.4 2.2 2 0 0 2 2 2 2 Protein of unknown function C-terminus (DUF2451) Thiolase_N PF00108.23 PIK49554.1 - 7e-78 261.6 1.9 9.7e-78 261.1 1.9 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK49554.1 - 2.1e-49 166.3 0.2 4.2e-49 165.3 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 PIK49554.1 - 3.5e-05 23.5 0.1 0.00011 21.9 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 PIK49554.1 - 0.00015 21.8 0.0 0.00097 19.3 0.0 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 PIK49554.1 - 0.0055 16.5 0.7 2.1 8.2 0.1 2.6 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Dodecin PF07311.12 PIK49554.1 - 0.068 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Dodecin Integrin_alpha2 PF08441.12 PIK49555.1 - 1.3e-87 294.7 0.1 4e-87 293.0 0.1 1.7 1 1 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK49555.1 - 1.4e-19 69.8 31.5 2.3e-12 46.8 5.3 5.2 5 0 0 5 5 5 3 FG-GAP repeat VCBS PF13517.6 PIK49555.1 - 2.9e-10 40.6 13.5 1.3e-08 35.3 6.8 3.5 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella rve PF00665.26 PIK49556.1 - 3.1e-17 62.8 0.0 1.6e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK49556.1 - 2.1e-13 50.2 0.3 4.4e-13 49.1 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain SOCS_box PF07525.16 PIK49556.1 - 0.02 15.2 0.6 9.5 6.7 0.0 2.7 2 0 0 2 2 2 0 SOCS box RVT_1 PF00078.27 PIK49557.1 - 5.1e-28 98.1 0.0 8.3e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flu_PB2 PF00604.17 PIK49557.1 - 0.13 10.1 0.0 0.19 9.6 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 Ldl_recept_b PF00058.17 PIK49560.1 - 4.9e-55 183.7 14.2 3.5e-11 43.4 0.1 9.2 10 0 0 10 10 10 6 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK49560.1 - 7.1e-11 42.2 0.7 0.00025 20.7 0.2 4.1 3 1 1 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 PIK49560.1 - 3.1e-09 36.9 8.1 6.1e-09 36.0 8.1 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Arylesterase PF01731.20 PIK49560.1 - 0.0001 22.4 0.0 13 6.1 0.0 5.9 6 1 1 7 7 7 1 Arylesterase NHL PF01436.21 PIK49560.1 - 0.00052 19.9 0.1 11 6.3 0.0 5.7 6 0 0 6 6 6 1 NHL repeat cEGF PF12662.7 PIK49560.1 - 0.0041 17.0 3.6 0.012 15.5 3.6 1.8 1 0 0 1 1 1 1 Complement Clr-like EGF-like Zn_ribbon_SprT PF17283.2 PIK49560.1 - 0.68 9.9 8.4 7 6.7 1.2 3.6 2 1 1 3 3 3 0 SprT-like zinc ribbon domain Trypan_PARP PF05887.11 PIK49561.1 - 0.00032 20.7 6.8 0.00053 20.0 6.8 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Prefoldin PF02996.17 PIK49562.1 - 0.096 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit Ephrin_rec_like PF07699.13 PIK49563.1 - 0.014 15.2 4.0 0.014 15.2 4.0 4.9 3 3 1 4 4 4 0 Putative ephrin-receptor like NCD3G PF07562.14 PIK49563.1 - 0.072 13.1 20.8 0.096 12.7 1.1 4.2 3 1 1 4 4 4 0 Nine Cysteines Domain of family 3 GPCR DUF1077 PF06417.12 PIK49563.1 - 0.31 11.1 1.6 0.83 9.7 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1077) YccF PF03733.13 PIK49563.1 - 3.5 8.4 13.9 30 5.4 1.1 3.9 3 0 0 3 3 3 0 Inner membrane component domain OppC_N PF12911.7 PIK49563.1 - 6.4 6.8 8.1 26 4.9 0.0 3.6 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C ANF_receptor PF01094.28 PIK49564.1 - 3.8e-11 42.7 0.0 4.3e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK49564.1 - 1e-06 28.7 0.0 1.3e-06 28.3 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Arf PF00025.21 PIK49565.1 - 3.1e-33 114.7 0.0 3.4e-31 108.0 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK49565.1 - 0.00024 20.6 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK49565.1 - 0.00031 20.2 0.1 0.00042 19.8 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK49565.1 - 0.059 13.0 0.0 0.18 11.4 0.0 1.8 1 1 0 1 1 1 0 Ras family Roc PF08477.13 PIK49565.1 - 0.11 12.7 0.0 2.6 8.3 0.0 2.2 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase LRR_9 PF14580.6 PIK49566.1 - 6.3e-13 48.6 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK49566.1 - 4.8e-10 39.5 9.3 5.4e-08 33.0 0.7 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK49566.1 - 1.5e-06 27.9 2.5 3.6e-05 23.4 2.5 2.5 1 1 1 2 2 2 2 Leucine rich repeat IQ PF00612.27 PIK49566.1 - 0.00017 21.1 11.2 0.041 13.7 2.4 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif LRR_1 PF00560.33 PIK49566.1 - 6.9 7.6 5.7 47 5.1 1.1 3.8 3 1 0 3 3 3 0 Leucine Rich Repeat S4 PF01479.25 PIK49567.1 - 1.3e-10 40.8 0.0 3.3e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 PIK49567.1 - 1.1e-09 39.1 4.8 1.6e-09 38.5 4.7 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain CHD5 PF04420.14 PIK49567.1 - 0.0097 15.8 0.8 0.016 15.1 0.8 1.5 1 0 0 1 1 1 1 CHD5-like protein Ets PF00178.22 PIK49567.1 - 0.056 13.9 3.0 0.29 11.6 1.5 2.5 2 1 0 2 2 2 0 Ets-domain ABC_tran PF00005.27 PIK49568.1 - 2.2e-45 154.6 0.0 1e-23 84.4 0.0 4.1 5 1 0 5 5 2 2 ABC transporter AAA_21 PF13304.6 PIK49568.1 - 1.2e-11 45.0 20.3 0.0029 17.5 0.1 5.6 4 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK49568.1 - 7.9e-09 35.3 9.7 0.0012 18.3 0.0 4.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 PIK49568.1 - 1.1e-07 32.4 0.0 0.016 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_tran_Xtn PF12848.7 PIK49568.1 - 2e-07 30.9 10.3 2e-07 30.9 10.3 5.9 6 0 0 6 6 4 1 ABC transporter RsgA_GTPase PF03193.16 PIK49568.1 - 2.7e-07 30.7 0.1 0.0078 16.1 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 PIK49568.1 - 1.5e-06 27.8 0.5 0.0041 16.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 PIK49568.1 - 3.9e-06 26.9 0.2 0.076 12.9 0.1 2.4 2 0 0 2 2 2 2 NACHT domain AAA_14 PF13173.6 PIK49568.1 - 7.5e-06 26.0 1.4 0.62 10.1 0.0 4.1 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.23 PIK49568.1 - 1.2e-05 25.4 0.1 0.0071 16.4 0.0 3.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 PIK49568.1 - 2.4e-05 24.6 0.0 0.37 11.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 PIK49568.1 - 3.2e-05 24.2 0.2 0.1 12.9 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA PF00004.29 PIK49568.1 - 7.8e-05 23.1 1.9 0.31 11.5 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 PIK49568.1 - 0.00012 21.4 0.3 0.17 11.0 0.1 2.9 2 1 0 2 2 2 2 NB-ARC domain AAA_33 PF13671.6 PIK49568.1 - 0.00016 21.9 0.0 1.1 9.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 PIK49568.1 - 0.00027 20.7 5.1 0.15 11.8 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_30 PF13604.6 PIK49568.1 - 0.00029 20.6 0.2 0.85 9.3 0.0 3.2 3 1 0 3 3 2 2 AAA domain NTPase_1 PF03266.15 PIK49568.1 - 0.001 19.0 0.2 1.4 8.8 0.0 2.8 3 0 0 3 3 2 2 NTPase cobW PF02492.19 PIK49568.1 - 0.001 18.7 0.0 0.25 10.9 0.0 2.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 PIK49568.1 - 0.0011 19.4 0.0 1.1 9.7 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_23 PF13476.6 PIK49568.1 - 0.0011 19.5 0.2 0.01 16.4 0.0 6.2 5 1 0 5 5 4 2 AAA domain Roc PF08477.13 PIK49568.1 - 0.0014 18.9 0.0 3.4 7.9 0.0 3.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 PIK49568.1 - 0.0038 16.8 0.1 4.9 6.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain SRP54 PF00448.22 PIK49568.1 - 0.0041 16.8 0.3 0.57 9.8 0.0 2.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_5 PF07728.14 PIK49568.1 - 0.0065 16.5 1.0 4.3 7.3 0.0 2.9 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK49568.1 - 0.0066 16.0 0.0 4.2 6.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Eapp_C PF10238.9 PIK49568.1 - 0.012 15.7 0.6 0.012 15.7 0.6 5.1 3 1 2 5 5 2 0 E2F-associated phosphoprotein Mg_chelatase PF01078.21 PIK49568.1 - 0.017 14.5 0.1 30 3.9 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 PIK49568.1 - 0.039 13.6 0.0 0.35 10.5 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MeaB PF03308.16 PIK49568.1 - 0.079 11.9 0.0 4.6 6.2 0.0 2.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 PIK49568.1 - 0.08 12.7 0.1 9.7 5.9 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_18 PF13238.6 PIK49568.1 - 0.082 13.5 16.5 0.16 12.5 0.3 5.3 4 2 0 4 4 2 0 AAA domain RuvB_N PF05496.12 PIK49568.1 - 0.11 12.2 0.3 9.2 6.0 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain FeoB_N PF02421.18 PIK49568.1 - 0.12 11.9 0.2 5.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF87 PF01935.17 PIK49568.1 - 0.5 10.4 0.0 0.5 10.4 0.0 4.7 4 1 1 5 5 4 0 Helicase HerA, central domain DUF3987 PF13148.6 PIK49568.1 - 6.4 5.7 0.0 6.4 5.7 0.0 4.7 4 1 1 5 5 4 0 Protein of unknown function (DUF3987) Musclin PF11037.8 PIK49569.1 - 0.02 14.8 0.0 0.072 13.0 0.0 1.9 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle NmrA PF05368.13 PIK49571.1 - 5e-38 131.0 0.2 6.5e-38 130.6 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 PIK49571.1 - 3.5e-14 53.1 0.1 4.6e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 PIK49571.1 - 1.7e-06 27.2 0.0 2.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK49571.1 - 3.5e-05 23.4 0.0 5.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK49571.1 - 0.0012 19.1 0.1 0.0021 18.3 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 PIK49571.1 - 0.002 18.6 0.2 0.0042 17.5 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 PIK49571.1 - 0.071 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain RmlD_sub_bind PF04321.17 PIK49571.1 - 0.089 11.9 0.2 0.14 11.3 0.2 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Ndc80_HEC PF03801.13 PIK49571.1 - 0.11 12.2 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 HEC/Ndc80p family Exo_endo_phos_2 PF14529.6 PIK49572.1 - 1.1e-07 31.8 2.0 4.2e-05 23.4 0.0 2.7 1 1 1 2 2 2 2 Endonuclease-reverse transcriptase DPCD PF14913.6 PIK49572.1 - 0.076 12.4 0.3 0.67 9.3 0.0 2.2 2 0 0 2 2 2 0 DPCD protein family T4-Gluco-transf PF09198.10 PIK49572.1 - 0.34 10.6 2.6 0.4 10.3 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase RVT_1 PF00078.27 PIK49573.1 - 3e-31 108.7 0.1 3.6e-31 108.4 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flavodoxin_1 PF00258.25 PIK49574.1 - 7.4e-24 84.6 0.0 1.1e-23 84.0 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin LIM PF00412.22 PIK49575.1 - 1.5e-31 108.4 17.0 3.1e-16 59.3 7.4 2.4 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 PIK49575.1 - 4.9e-19 67.9 3.4 7.6e-19 67.3 3.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK49575.1 - 3e-05 23.8 0.2 6.6e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK49575.1 - 0.0056 16.1 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF2358 PF10184.9 PIK49576.1 - 5.8e-24 84.5 0.0 8.7e-24 84.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) DSPc PF00782.20 PIK49577.1 - 2.2e-27 95.5 0.1 2.7e-27 95.2 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK49577.1 - 0.0075 15.9 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Laminin_G_2 PF02210.24 PIK49578.1 - 1.1e-14 55.1 0.0 2.2e-11 44.4 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK49578.1 - 9.4e-11 42.1 0.0 6.1e-08 32.9 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 PIK49579.1 - 5.5e-52 173.6 127.9 1.6e-06 28.3 7.3 9.3 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 PIK49579.1 - 1.3e-33 114.4 116.6 9.7e-05 22.9 3.4 10.8 10 0 0 10 10 10 9 Human growth factor-like EGF EGF_CA PF07645.15 PIK49579.1 - 2e-24 85.5 134.1 1.3e-05 25.3 7.3 9.3 4 2 5 9 9 9 9 Calcium-binding EGF domain EGF_2 PF07974.13 PIK49579.1 - 2.1e-14 53.6 153.2 0.0021 18.4 11.0 9.6 9 0 0 9 9 9 8 EGF-like domain EGF PF00008.27 PIK49580.1 - 7.2e-144 467.4 358.3 3.3e-09 36.9 1.4 27.6 27 0 0 27 27 27 27 EGF-like domain hEGF PF12661.7 PIK49580.1 - 2.5e-70 230.9 304.0 4.8e-06 27.0 1.8 28.4 27 0 0 27 27 27 22 Human growth factor-like EGF Laminin_G_2 PF02210.24 PIK49580.1 - 1.2e-42 145.5 0.1 2.5e-15 57.2 0.0 3.6 3 1 0 3 3 3 3 Laminin G domain EGF_CA PF07645.15 PIK49580.1 - 1.4e-35 121.2 374.0 6.7e-08 32.6 6.4 27.6 16 6 11 27 27 27 16 Calcium-binding EGF domain Laminin_G_1 PF00054.23 PIK49580.1 - 2.2e-30 105.5 0.0 5.6e-12 46.0 0.0 3.6 4 0 0 4 4 4 3 Laminin G domain EGF_2 PF07974.13 PIK49580.1 - 1.5e-09 38.0 409.6 0.0036 17.6 9.9 27.6 27 0 0 27 27 27 16 EGF-like domain EGF_3 PF12947.7 PIK49580.1 - 1.6e-07 31.4 329.4 0.019 15.2 4.9 27.8 24 2 3 27 27 27 17 EGF domain EGF_MSP1_1 PF12946.7 PIK49580.1 - 0.0046 17.0 6.1 0.0046 17.0 6.1 23.5 25 0 0 25 25 25 8 MSP1 EGF domain 1 FXa_inhibition PF14670.6 PIK49580.1 - 0.89 9.9 326.6 0.052 13.8 4.8 28.0 11 8 17 28 28 28 0 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK49581.1 - 2.2e-42 142.9 132.6 5.1e-07 29.9 8.2 9.5 9 0 0 9 9 9 8 EGF-like domain EGF_CA PF07645.15 PIK49581.1 - 4.7e-20 71.5 39.7 7.5e-11 42.1 5.1 10.1 6 4 3 9 9 9 5 Calcium-binding EGF domain hEGF PF12661.7 PIK49581.1 - 1.4e-17 63.6 123.6 2e-05 25.1 4.5 11.9 11 2 0 11 11 11 7 Human growth factor-like EGF EGF_3 PF12947.7 PIK49581.1 - 6.3e-06 26.3 37.0 5e-05 23.4 5.5 10.5 6 4 3 9 9 9 5 EGF domain FXa_inhibition PF14670.6 PIK49581.1 - 0.00071 19.8 9.8 0.00071 19.8 9.8 9.4 7 1 2 9 9 9 6 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK49581.1 - 0.0098 16.2 15.7 0.0098 16.2 15.7 10.5 10 1 0 10 10 10 6 EGF-like domain cEGF PF12662.7 PIK49581.1 - 0.014 15.4 1.1 0.014 15.4 1.1 10.7 9 2 0 9 9 9 0 Complement Clr-like EGF-like DUF3169 PF11368.8 PIK49581.1 - 0.019 14.5 0.0 0.028 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Ribosomal_S18 PF01084.20 PIK49582.1 - 1.9e-14 53.6 0.0 3.8e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 DUF5318 PF17249.2 PIK49582.1 - 0.097 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5318) TF_Zn_Ribbon PF08271.12 PIK49582.1 - 0.1 12.1 0.1 0.23 11.0 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Fibrinogen_C PF00147.18 PIK49583.1 - 1.5e-40 139.4 0.1 1.9e-40 139.0 0.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK49584.1 - 2.4e-46 158.3 3.6 2.7e-46 158.1 3.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FAM221 PF14753.6 PIK49585.1 - 1.3e-90 302.3 3.0 1.3e-90 302.3 3.0 1.4 2 0 0 2 2 2 1 Protein FAM221A/B Lactamase_B_3 PF13483.6 PIK49586.1 - 1.9e-07 31.1 0.0 3.3e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Rieske PF00355.26 PIK49586.1 - 4.4e-06 26.6 0.1 8.7e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Lactamase_B_2 PF12706.7 PIK49586.1 - 6.4e-05 22.5 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FPN1 PF06963.12 PIK49588.1 - 2.2e-56 191.3 6.1 2.9e-56 190.9 6.1 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) DUF406 PF04175.12 PIK49588.1 - 0.032 14.7 0.0 0.067 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF406) TMEM208_SND2 PF05620.11 PIK49588.1 - 0.51 10.1 2.0 1.1 9.0 2.0 1.5 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 zf-RING_5 PF14634.6 PIK49589.1 - 0.00056 19.8 2.0 0.00056 19.8 2.0 3.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-UBP PF02148.19 PIK49589.1 - 8.4 6.8 12.7 0.41 11.0 5.3 2.6 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Ricin_B_lectin PF00652.22 PIK49590.1 - 4e-31 107.9 0.2 8.9e-31 106.8 0.2 1.6 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Glycos_transf_2 PF00535.26 PIK49590.1 - 5e-16 59.0 0.0 8.2e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 RicinB_lectin_2 PF14200.6 PIK49590.1 - 7.5e-10 39.4 0.0 7.4e-05 23.4 0.0 3.7 2 1 2 4 4 4 3 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.14 PIK49590.1 - 0.00012 21.7 0.0 0.00026 20.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK49590.1 - 0.0029 17.1 0.0 0.0081 15.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Rcd1 PF04078.13 PIK49591.1 - 2.3e-96 322.0 5.0 3.4e-56 190.4 0.2 3.0 3 0 0 3 3 3 3 Cell differentiation family, Rcd1-like CUB PF00431.20 PIK49592.1 - 2.2e-36 124.5 0.2 2.7e-16 59.9 0.3 3.6 3 1 0 3 3 3 3 CUB domain CUB_2 PF02408.20 PIK49592.1 - 0.06 13.1 0.0 0.84 9.4 0.0 2.3 2 0 0 2 2 2 0 CUB-like domain EamA PF00892.20 PIK49593.1 - 8e-11 42.3 36.9 2.4e-07 31.0 16.9 2.0 2 0 0 2 2 2 2 EamA-like transporter family EamA PF00892.20 PIK49594.1 - 8.2e-10 39.0 34.9 8e-07 29.3 16.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family zf-RING_2 PF13639.6 PIK49597.1 - 2.5e-07 30.9 5.8 5.2e-07 29.9 5.8 1.6 1 0 0 1 1 1 1 Ring finger domain PHD PF00628.29 PIK49597.1 - 0.00023 21.0 8.2 0.00023 21.0 8.2 2.1 2 0 0 2 2 1 1 PHD-finger EPL1 PF10513.9 PIK49597.1 - 0.0015 19.0 1.4 0.002 18.5 1.4 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Prok-RING_1 PF14446.6 PIK49597.1 - 0.0064 16.4 4.7 0.0064 16.4 4.7 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 TFIIA PF03153.13 PIK49597.1 - 0.009 16.1 15.9 0.012 15.7 15.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit C1_2 PF03107.16 PIK49597.1 - 0.02 15.2 5.9 0.033 14.5 3.2 2.4 2 0 0 2 2 2 0 C1 domain zf-ANAPC11 PF12861.7 PIK49597.1 - 0.02 15.0 2.7 0.054 13.5 2.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Spore_coat_CotO PF14153.6 PIK49597.1 - 0.051 13.5 7.8 0.078 12.9 7.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Zf_RING PF16744.5 PIK49597.1 - 0.055 13.6 8.5 0.19 11.9 8.5 1.9 1 1 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4 PF00097.25 PIK49597.1 - 0.06 13.2 2.0 0.2 11.6 2.1 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK49597.1 - 0.073 12.9 5.7 0.18 11.7 5.7 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NPR3 PF03666.13 PIK49597.1 - 0.094 11.5 5.9 0.12 11.1 5.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C3HC4_4 PF15227.6 PIK49597.1 - 0.11 12.7 4.4 0.29 11.3 4.4 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 PIK49597.1 - 0.13 12.5 7.5 0.34 11.1 7.5 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain PHD_4 PF16866.5 PIK49597.1 - 0.17 12.0 18.2 0.052 13.7 7.0 3.6 3 1 0 3 3 3 0 PHD-finger Hydin_ADK PF17213.3 PIK49597.1 - 0.17 12.2 5.5 0.28 11.5 5.5 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain OrfB_Zn_ribbon PF07282.11 PIK49597.1 - 0.18 11.8 3.6 0.43 10.5 0.6 2.7 3 0 0 3 3 2 0 Putative transposase DNA-binding domain Suf PF05843.14 PIK49597.1 - 0.18 11.7 6.5 0.26 11.3 6.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) zf-C3HC4_2 PF13923.6 PIK49597.1 - 0.19 11.6 8.5 0.73 9.7 8.1 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PAT1 PF09770.9 PIK49597.1 - 0.34 9.1 10.8 0.43 8.8 10.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 PIK49597.1 - 0.38 10.8 5.6 0.54 10.3 5.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 PIK49597.1 - 0.48 9.6 3.3 0.53 9.4 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1387 PF07139.11 PIK49597.1 - 0.57 9.9 12.0 0.82 9.3 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Presenilin PF01080.17 PIK49597.1 - 0.73 8.5 10.5 0.97 8.1 10.5 1.1 1 0 0 1 1 1 0 Presenilin TMEM51 PF15345.6 PIK49597.1 - 0.95 9.3 7.7 1.5 8.6 7.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DZR PF12773.7 PIK49597.1 - 1.1 9.3 6.8 44 4.2 6.8 2.5 1 1 0 1 1 1 0 Double zinc ribbon RR_TM4-6 PF06459.12 PIK49597.1 - 1.4 8.6 7.5 2 8.1 7.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zn_ribbon_17 PF17120.5 PIK49597.1 - 1.8 8.3 12.0 7.4 6.3 11.9 2.0 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type eIF-3_zeta PF05091.12 PIK49597.1 - 2.7 6.9 12.0 3.6 6.5 12.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SelP_N PF04592.14 PIK49597.1 - 3.3 7.0 19.8 5.3 6.4 19.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region zf-4CXXC_R1 PF10497.9 PIK49597.1 - 3.4 7.9 16.0 31 4.9 13.9 3.3 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_11 PF17123.5 PIK49597.1 - 3.5 7.5 7.5 1.2 8.9 4.3 1.9 2 0 0 2 2 2 0 RING-like zinc finger Spt20 PF12090.8 PIK49597.1 - 4.6 6.8 26.3 6.8 6.2 26.3 1.2 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 PIK49597.1 - 6.1 5.8 8.9 9.9 5.1 8.9 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Ribosomal_L37ae PF01780.19 PIK49597.1 - 6.8 6.9 11.3 0.3 11.2 1.1 3.0 3 0 0 3 3 2 0 Ribosomal L37ae protein family Androgen_recep PF02166.16 PIK49597.1 - 7.4 5.3 17.2 10 4.8 17.2 1.1 1 0 0 1 1 1 0 Androgen receptor zf-Sec23_Sec24 PF04810.15 PIK49597.1 - 9.1 6.4 9.7 13 5.9 4.2 3.3 2 1 2 4 4 4 0 Sec23/Sec24 zinc finger R3H PF01424.22 PIK49598.1 - 1.3e-15 57.1 0.2 2.5e-15 56.2 0.2 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 PIK49598.1 - 1.6e-09 37.6 72.5 4.8e-05 23.3 12.2 12.5 14 1 0 14 14 14 6 NF-X1 type zinc finger LppX_LprAFG PF07161.13 PIK49598.1 - 0.043 13.7 0.0 0.065 13.1 0.0 1.2 1 0 0 1 1 1 0 LppX_LprAFG lipoprotein Yae1_N PF09811.9 PIK49599.1 - 1.6e-05 24.5 4.3 3.9e-05 23.3 4.3 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Cobl PF09469.10 PIK49600.1 - 3.2e-07 30.5 0.0 7e-07 29.4 0.0 1.5 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.15 PIK49600.1 - 1.2e-06 28.5 0.0 0.05 13.7 0.0 2.2 2 0 0 2 2 2 2 Raf-like Ras-binding domain TUG-UBL1 PF11470.8 PIK49600.1 - 0.0019 18.4 0.0 0.024 14.8 0.0 2.2 2 0 0 2 2 2 1 TUG ubiquitin-like domain 7tm_2 PF00002.24 PIK49604.1 - 2e-59 200.9 20.6 2.7e-59 200.4 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK49604.1 - 1.4e-11 44.5 14.6 1.4e-11 44.5 14.6 1.9 2 0 0 2 2 2 1 Hormone receptor domain DUF563 PF04577.14 PIK49605.1 - 1.9e-14 54.3 0.0 2.9e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Y_phosphatase PF00102.27 PIK49606.1 - 9.7e-90 300.2 4.1 1.6e-71 240.6 2.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK49606.1 - 0.00012 21.9 0.1 0.00037 20.3 0.1 1.8 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK49606.1 - 0.00032 20.8 0.0 0.00049 20.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK49606.1 - 0.0035 17.5 0.1 0.051 13.7 0.0 2.7 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK49606.1 - 0.02 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK49607.1 - 1.1e-28 100.4 0.1 1.3e-28 100.2 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK49607.1 - 0.039 13.8 0.1 0.05 13.4 0.1 1.4 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Ribosomal_L22e PF01776.17 PIK49608.1 - 1.5e-25 89.7 0.6 2e-25 89.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3211 PF11485.8 PIK49608.1 - 0.071 13.3 0.1 0.14 12.4 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3211) G_path_suppress PF15991.5 PIK49609.1 - 2e-36 126.6 25.1 2e-36 126.6 25.1 2.0 1 1 1 2 2 2 1 G-protein pathway suppressor Kazal_2 PF07648.15 PIK49610.1 - 1.2e-32 111.8 53.9 8.6e-10 38.6 3.9 8.5 10 0 0 10 10 10 5 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK49610.1 - 7.9e-26 89.8 84.9 3.2e-08 33.5 12.1 6.9 6 1 0 6 6 6 5 Kazal-type serine protease inhibitor domain Laminin_G_1 PF00054.23 PIK49610.1 - 5.9e-17 62.1 0.0 2e-16 60.4 0.0 1.8 2 0 0 2 2 2 1 Laminin G domain Laminin_EGF PF00053.24 PIK49610.1 - 6.7e-14 51.8 31.3 2e-08 34.2 12.4 10.9 9 2 2 11 11 11 2 Laminin EGF domain Laminin_G_2 PF02210.24 PIK49610.1 - 4.7e-13 49.8 0.2 2e-12 47.8 0.1 2.0 2 0 0 2 2 2 1 Laminin G domain EGF PF00008.27 PIK49610.1 - 0.0019 18.4 7.1 0.0019 18.4 7.1 10.4 8 1 1 9 9 9 3 EGF-like domain Laminin_G_3 PF13385.6 PIK49610.1 - 0.03 14.5 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 PIK49611.1 - 2.1e-16 60.3 0.0 4.7e-16 59.2 0.0 1.5 2 0 0 2 2 2 1 Laminin G domain Laminin_G_2 PF02210.24 PIK49611.1 - 1.2e-12 48.6 0.0 2.2e-12 47.7 0.0 1.4 2 0 0 2 2 2 1 Laminin G domain EGF PF00008.27 PIK49611.1 - 7.8e-09 35.7 24.1 0.00023 21.4 8.8 2.8 2 1 0 2 2 2 2 EGF-like domain hEGF PF12661.7 PIK49611.1 - 3.1e-06 27.6 17.7 0.012 16.2 4.4 3.1 2 1 0 2 2 2 2 Human growth factor-like EGF EGF_3 PF12947.7 PIK49611.1 - 0.023 14.9 20.7 0.12 12.6 8.4 2.6 2 0 0 2 2 2 0 EGF domain Laminin_G_3 PF13385.6 PIK49611.1 - 0.11 12.7 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 PIK49611.1 - 0.36 11.2 28.8 0.76 10.2 8.5 2.5 2 0 0 2 2 2 0 EGF-like domain GREB1 PF15782.5 PIK49612.1 - 2.8 5.0 7.9 2.9 4.9 7.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Laminin_G_1 PF00054.23 PIK49613.1 - 5.9e-27 94.5 0.0 7e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 PIK49613.1 - 9e-26 90.9 0.0 1.4e-25 90.3 0.0 1.3 1 1 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 PIK49613.1 - 0.023 14.8 0.0 0.029 14.5 0.0 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 PIK49614.1 - 3.1e-15 56.6 0.0 4e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 PIK49614.1 - 3.9e-13 50.1 0.0 5.3e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 PIK49614.1 - 0.0031 17.8 3.7 0.0053 17.0 3.7 1.4 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK49614.1 - 0.0048 17.5 4.8 0.011 16.4 4.8 1.7 1 0 0 1 1 1 1 Human growth factor-like EGF Laminin_EGF PF00053.24 PIK49614.1 - 0.063 13.4 3.4 0.1 12.8 3.4 1.3 1 0 0 1 1 1 0 Laminin EGF domain Laminin_G_3 PF13385.6 PIK49614.1 - 0.063 13.4 0.0 0.081 13.1 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily FXa_inhibition PF14670.6 PIK49614.1 - 0.15 12.4 4.8 0.3 11.4 4.8 1.5 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK49614.1 - 0.19 12.1 4.5 0.32 11.4 4.5 1.4 1 0 0 1 1 1 0 EGF-like domain EGF_CA PF07645.15 PIK49614.1 - 0.38 11.0 4.3 0.66 10.2 4.3 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain PCM1_C PF15717.5 PIK49615.1 - 0.25 10.0 10.3 0.28 9.8 10.3 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Tme5_EGF_like PF09064.10 PIK49615.1 - 0.43 10.5 4.9 0.73 9.8 4.9 1.3 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like NOT2_3_5 PF04153.18 PIK49618.1 - 0.098 12.7 0.5 0.23 11.5 0.5 1.6 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family DUF2195 PF09961.9 PIK49619.1 - 0.017 15.1 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2195) SH3_2 PF07653.17 PIK49620.1 - 2e-25 88.3 0.0 2.8e-12 46.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 PIK49620.1 - 9.3e-23 79.8 3.1 8e-11 41.6 0.1 3.0 2 1 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK49620.1 - 1.6e-12 46.8 0.7 5.8e-05 22.6 0.4 3.2 2 1 0 2 2 2 2 SH3 domain fn3 PF00041.21 PIK49621.1 - 1.4e-12 47.8 2.1 4.1e-06 27.0 0.1 3.3 2 2 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK49621.1 - 6e-05 23.5 0.1 0.089 13.4 0.0 3.4 2 2 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain DUF4249 PF14054.6 PIK49621.1 - 0.032 13.9 0.0 0.2 11.2 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4249) ChitinaseA_N PF08329.10 PIK49621.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 1 0 1 1 1 0 Chitinase A, N-terminal domain DUF4091 PF13320.6 PIK49622.1 - 0.0086 16.2 0.3 0.017 15.2 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4091) TrkA_C PF02080.21 PIK49622.1 - 0.0092 15.8 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 TrkA-C domain SH3_2 PF07653.17 PIK49622.1 - 0.076 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.6 PIK49622.1 - 0.094 12.6 0.8 0.21 11.5 0.2 1.9 2 1 0 2 2 2 0 Variant SH3 domain DEAD PF00270.29 PIK49623.1 - 4.1e-11 43.0 0.2 9.8e-11 41.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Strabismus PF06638.11 PIK49623.1 - 0.016 13.9 0.1 0.022 13.5 0.1 1.2 1 0 0 1 1 1 0 Strabismus protein LRIF1 PF15741.5 PIK49623.1 - 0.063 11.8 7.7 0.079 11.5 7.7 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Nucleo_P87 PF07267.11 PIK49623.1 - 0.38 9.6 4.6 0.47 9.2 4.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Helicase_C PF00271.31 PIK49624.1 - 6.6e-32 110.2 1.2 1.3e-30 106.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK49624.1 - 0.00014 21.6 0.0 0.00033 20.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase TPMT PF05724.11 PIK49625.1 - 7.3e-52 176.2 0.0 8.9e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 PIK49625.1 - 0.0011 19.5 0.0 0.004 17.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK49625.1 - 0.0013 19.3 0.0 0.013 16.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK49625.1 - 0.0023 17.7 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK49625.1 - 0.052 12.8 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase CheR PF01739.18 PIK49625.1 - 0.052 13.0 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Cu-oxidase PF00394.22 PIK49626.1 - 6.9e-21 75.0 0.0 1e-20 74.4 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase RVT_1 PF00078.27 PIK49627.1 - 3.4e-42 144.5 0.0 4.2e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4085 PF13315.6 PIK49627.1 - 0.12 11.9 0.0 0.28 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4085) Voltage_CLC PF00654.20 PIK49628.1 - 1.5e-30 106.7 11.7 1.3e-29 103.6 11.7 1.9 1 1 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 PIK49628.1 - 6.1e-05 23.4 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 CBS domain Tmemb_161AB PF10268.9 PIK49628.1 - 0.14 10.8 3.5 0.035 12.8 0.4 1.5 2 0 0 2 2 2 0 Predicted transmembrane protein 161AB Voltage_CLC PF00654.20 PIK49629.1 - 4.3e-23 82.1 1.7 4.5e-21 75.5 0.4 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel Tubulin_C PF03953.17 PIK49630.1 - 2e-27 95.9 0.0 2.5e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin C-terminal domain Peptidase_M17 PF00883.21 PIK49631.1 - 1.6e-98 329.8 0.0 2.1e-98 329.5 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 PIK49631.1 - 3.9e-21 75.5 0.2 1.2e-20 74.0 0.2 1.9 1 0 0 1 1 1 1 M17 aminopeptidase N-terminal domain 2 CENP-T_C PF15511.6 PIK49632.1 - 2.9e-26 91.7 0.1 8e-26 90.3 0.1 1.8 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 PIK49632.1 - 9.8e-10 38.7 0.1 2.5e-09 37.4 0.1 1.7 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 PIK49632.1 - 1.3e-06 28.6 0.0 3.7e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK49632.1 - 8.9e-05 22.9 0.1 8.9e-05 22.9 0.1 3.1 3 1 0 3 3 3 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 PIK49632.1 - 0.0042 17.1 0.0 0.0095 15.9 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 PIK49632.1 - 0.11 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A EF-hand_7 PF13499.6 PIK49633.1 - 0.035 14.5 0.0 0.16 12.5 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair CAP PF00188.26 PIK49634.1 - 1.1e-16 61.8 1.5 1.5e-16 61.4 1.5 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family AMP-binding PF00501.28 PIK49635.1 - 6.7e-51 173.2 0.0 1e-50 172.6 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK49635.1 - 0.0064 17.4 1.0 0.011 16.7 1.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK49636.1 - 1.7e-47 162.0 0.5 1.6e-33 116.0 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 PIK49636.1 - 7.1e-21 75.0 0.4 1.2e-20 74.2 0.4 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RT_RNaseH PF17917.1 PIK49637.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase HalOD1 PF18545.1 PIK49637.1 - 0.14 12.4 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Halobacterial output domain 1 SURF4 PF02077.15 PIK49638.1 - 2.1e-116 388.2 6.1 2.3e-116 388.1 6.1 1.0 1 0 0 1 1 1 1 SURF4 family SURF2 PF05477.11 PIK49638.1 - 1.1e-15 58.0 0.0 1.4e-15 57.7 0.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) DoxX PF07681.12 PIK49638.1 - 0.022 15.4 0.1 0.022 15.4 0.1 3.6 3 2 1 4 4 4 0 DoxX DUF4808 PF16066.5 PIK49638.1 - 0.031 14.8 0.6 0.062 13.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) DUF4483 PF14825.6 PIK49640.1 - 4.3e-48 163.1 0.0 6e-48 162.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4483) Peptidase_S10 PF00450.22 PIK49640.1 - 0.072 12.5 0.0 0.085 12.2 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase Fibrinogen_C PF00147.18 PIK49641.1 - 8.7e-55 185.9 3.7 9.7e-55 185.8 3.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain GIY-YIG PF01541.24 PIK49642.1 - 0.0032 17.7 0.1 0.025 14.8 0.2 2.2 2 0 0 2 2 2 1 GIY-YIG catalytic domain RVT_1 PF00078.27 PIK49642.1 - 0.0054 16.3 0.0 0.014 14.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Abhydrolase_3 PF07859.13 PIK49643.1 - 7.2e-15 55.4 0.9 9.8e-15 55.0 0.9 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK49643.1 - 0.0025 16.8 0.1 0.049 12.5 0.0 2.0 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_6 PF12697.7 PIK49643.1 - 0.0071 17.0 0.5 0.0098 16.5 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 PIK49643.1 - 0.017 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 PIK49643.1 - 0.026 14.2 0.1 1.6 8.3 0.0 2.3 2 1 0 2 2 2 0 Putative esterase Peptidase_S9 PF00326.21 PIK49643.1 - 0.043 13.3 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 PIK49643.1 - 0.073 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 PIK49643.1 - 0.08 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Chlorophyllase2 PF12740.7 PIK49643.1 - 0.17 10.7 1.0 0.68 8.8 1.0 1.8 1 1 0 1 1 1 0 Chlorophyllase enzyme U3_assoc_6 PF08640.11 PIK49644.1 - 2.8e-25 88.2 9.0 4e-25 87.7 9.0 1.2 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 DUF3450 PF11932.8 PIK49644.1 - 0.046 13.0 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) VEK-30 PF12107.8 PIK49644.1 - 0.85 9.6 4.2 2 8.4 4.2 1.7 1 0 0 1 1 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway RVT_1 PF00078.27 PIK49645.1 - 3.2e-21 75.9 0.1 1.3e-20 73.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3896 PF13035.6 PIK49645.1 - 0.034 14.3 0.3 0.12 12.6 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) TPR_14 PF13428.6 PIK49646.1 - 2.5e-10 40.3 1.0 0.00034 21.2 0.0 5.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49646.1 - 0.02 15.4 0.1 11 6.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK49646.1 - 0.025 15.2 0.1 2.7 8.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49646.1 - 0.041 14.0 0.5 4.4 7.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK49646.1 - 0.078 13.7 0.2 23 5.9 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Thymidylat_synt PF00303.19 PIK49646.1 - 0.092 11.9 0.2 0.89 8.6 0.1 2.1 2 0 0 2 2 2 0 Thymidylate synthase Phage_int_SAM_4 PF13495.6 PIK49647.1 - 0.001 19.5 0.1 0.002 18.6 0.1 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK49647.1 - 0.0023 18.2 0.2 0.0063 16.8 0.2 1.7 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Herpes_BLLF1 PF05109.13 PIK49647.1 - 0.015 13.3 6.0 0.031 12.3 6.0 1.4 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Phage_integrase PF00589.22 PIK49647.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Phage integrase family Band_7 PF01145.25 PIK49648.1 - 8.2e-34 117.2 1.2 1e-33 116.8 1.2 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 PIK49648.1 - 0.00068 19.4 0.1 0.00095 18.9 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 PIK49648.1 - 0.05 14.0 0.3 0.1 13.0 0.3 1.6 1 0 0 1 1 1 0 Phage protein Gp68 HAD_2 PF13419.6 PIK49649.1 - 2.5e-19 70.1 0.0 3.6e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK49649.1 - 1.8e-12 48.0 0.0 2.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK49649.1 - 4.2e-07 29.9 0.0 7.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 PIK49649.1 - 0.011 16.2 0.0 0.026 14.9 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase TPR_12 PF13424.6 PIK49650.1 - 7.7e-06 26.1 3.1 0.0012 19.1 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49650.1 - 0.00063 19.7 0.6 0.57 10.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK49650.1 - 0.00073 19.3 0.1 1.8 8.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49650.1 - 0.0013 18.5 0.4 0.043 13.6 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat HutP PF09021.11 PIK49650.1 - 0.0093 16.3 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 HutP DUF1926 PF09095.11 PIK49650.1 - 0.063 12.9 0.1 0.071 12.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1926) SET PF00856.28 PIK49651.1 - 7.3e-10 39.5 1.4 1.4e-08 35.4 1.4 3.0 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 PIK49651.1 - 7.3e-07 29.2 18.2 7.3e-07 29.2 18.2 3.1 2 1 0 2 2 2 1 MYND finger IBR PF01485.21 PIK49651.1 - 0.017 15.4 0.6 0.017 15.4 0.6 3.7 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain PKD_channel PF08016.12 PIK49652.1 - 3.2e-66 223.8 8.8 6.2e-66 222.8 8.8 1.5 1 0 0 1 1 1 1 Polycystin cation channel Colipase-like PF15083.6 PIK49652.1 - 0.0079 16.3 17.2 0.46 10.6 0.7 6.1 1 1 5 6 6 6 3 Colipase-like REJ PF02010.15 PIK49653.1 - 4.3e-32 111.5 0.0 7.7e-32 110.7 0.0 1.4 1 0 0 1 1 1 1 REJ domain PLAT PF01477.23 PIK49653.1 - 1.5e-20 73.9 0.2 2.6e-18 66.7 0.0 2.9 2 1 1 3 3 3 1 PLAT/LH2 domain GPS PF01825.21 PIK49653.1 - 2.3e-09 37.6 2.9 6.6e-09 36.2 2.9 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD PF00801.20 PIK49654.1 - 8.2e-06 25.6 16.8 0.099 12.5 2.1 6.0 5 1 0 5 5 5 3 PKD domain REJ PF02010.15 PIK49654.1 - 0.0001 21.3 0.0 0.00057 18.8 0.0 2.1 2 0 0 2 2 2 1 REJ domain Ig_3 PF13927.6 PIK49654.1 - 0.14 12.8 0.3 3.1 8.5 0.1 3.2 3 0 0 3 3 3 0 Immunoglobulin domain DUF1488 PF07369.11 PIK49654.1 - 0.19 11.7 0.0 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) PKD PF00801.20 PIK49655.1 - 1.2e-07 31.5 7.0 1.6e-05 24.7 3.9 3.3 3 0 0 3 3 3 2 PKD domain TcfC PF16967.5 PIK49655.1 - 0.14 11.7 0.2 0.62 9.6 0.0 2.2 3 0 0 3 3 3 0 E-set like domain SNF PF00209.18 PIK49656.1 - 1e-162 542.5 33.2 3.7e-160 534.1 33.2 2.9 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family cNMP_binding PF00027.29 PIK49657.1 - 6.8e-49 163.9 0.1 8.7e-16 57.8 0.0 3.7 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Collectrin PF16959.5 PIK49657.1 - 0.0039 17.0 0.1 0.0093 15.8 0.1 1.6 1 0 0 1 1 1 1 Renal amino acid transporter DUF1389 PF07146.11 PIK49657.1 - 0.069 12.4 0.4 0.84 8.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1389) TMEM154 PF15102.6 PIK49657.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family Orf78 PF06024.12 PIK49657.1 - 0.13 12.6 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Orf78 (ac78) Patatin PF01734.22 PIK49658.1 - 2.4e-22 80.1 0.0 4.4e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Ank_2 PF12796.7 PIK49659.1 - 1.7e-25 89.4 0.1 1e-09 38.8 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK49659.1 - 4.7e-14 52.6 0.0 3.8e-06 27.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK49659.1 - 5.8e-13 48.8 0.0 7.6e-06 26.1 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK49659.1 - 6.2e-13 47.7 0.0 0.057 14.0 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK49659.1 - 1.5e-10 41.0 0.0 0.0033 17.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat AA_permease_2 PF13520.6 PIK49660.1 - 3.8e-28 98.5 21.0 5.3e-28 98.0 21.0 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK49660.1 - 9.7e-10 37.6 17.6 3.2e-09 35.9 17.7 1.7 1 1 0 1 1 1 1 Amino acid permease DUF1453 PF07301.11 PIK49660.1 - 9.7 6.2 15.8 0.23 11.5 3.4 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1453) Forkhead PF00250.18 PIK49661.1 - 9.1e-40 134.8 0.1 1.5e-39 134.2 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain GDP_Man_Dehyd PF16363.5 PIK49662.1 - 1.3e-125 419.2 0.0 1.5e-125 419.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK49662.1 - 3.8e-64 216.4 0.0 4.5e-64 216.2 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 PIK49662.1 - 0.0085 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Asp_protease_2 PF13650.6 PIK49663.1 - 0.003 18.2 1.1 0.05 14.3 0.0 2.4 2 0 0 2 2 2 1 Aspartyl protease PRMT5_C PF17286.2 PIK49664.1 - 7.4e-54 182.3 0.6 8.7e-54 182.1 0.6 1.1 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 PIK49664.1 - 3.2e-19 69.4 0.0 4.6e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5 PF05185.16 PIK49665.1 - 1.2e-40 139.2 0.1 1.4e-40 138.9 0.1 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase COX4 PF02936.14 PIK49666.1 - 3.1e-28 98.5 0.0 3.9e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF2189 PF09955.9 PIK49666.1 - 0.099 12.9 0.1 0.18 12.0 0.1 1.4 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) Cytochrom_C1 PF02167.15 PIK49667.1 - 1.4e-37 129.6 0.1 1.7e-37 129.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 PIK49667.1 - 0.00098 19.4 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 PIK49667.1 - 0.0077 17.3 0.1 0.012 16.7 0.1 1.5 1 1 0 1 1 1 1 Cytochrome c ComFB PF10719.9 PIK49667.1 - 0.1 12.7 0.5 0.19 11.8 0.5 1.4 1 0 0 1 1 1 0 Late competence development protein ComFB Cytochrom_C1 PF02167.15 PIK49668.1 - 3e-49 167.7 0.0 3.3e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family TLD PF07534.16 PIK49669.1 - 1.9e-30 105.9 0.2 4e-30 104.8 0.2 1.6 1 0 0 1 1 1 1 TLD LRR_4 PF12799.7 PIK49671.1 - 1.1e-06 28.8 11.7 0.00032 21.0 0.6 2.8 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK49671.1 - 0.00023 20.9 9.4 0.019 14.7 0.4 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 PIK49671.1 - 0.014 15.4 8.7 0.11 12.6 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat p450 PF00067.22 PIK49672.1 - 6.4e-73 246.1 0.0 1.3e-48 165.9 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 FAM117 PF15388.6 PIK49673.1 - 1.3e-50 172.7 13.7 2.2e-50 171.9 13.7 1.4 1 0 0 1 1 1 1 Protein Family FAM117 7tm_1 PF00001.21 PIK49674.1 - 1.9e-32 112.6 23.2 2.5e-32 112.3 23.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK49674.1 - 6.4e-08 32.3 9.2 1.1e-07 31.5 9.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK49674.1 - 2.4e-05 23.9 14.4 4.8e-05 22.9 14.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 PIK49674.1 - 2.6e-05 24.1 10.2 2.6e-05 24.1 10.2 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 PLAC8 PF04749.17 PIK49674.1 - 0.52 11.3 0.1 0.52 11.3 0.1 3.2 2 1 0 2 2 2 0 PLAC8 family CD225 PF04505.12 PIK49675.1 - 2.6e-19 69.1 0.4 2.6e-19 69.1 0.4 1.4 2 0 0 2 2 2 1 Interferon-induced transmembrane protein Herpes_UL56 PF04534.12 PIK49675.1 - 0.0043 16.6 0.0 0.005 16.4 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL56 protein GCIP PF13324.6 PIK49676.1 - 2.5e-11 43.7 0.2 4.1e-11 43.0 0.2 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Serine_rich PF08824.10 PIK49676.1 - 0.032 14.2 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Serine rich protein interaction domain FTCD_N PF07837.12 PIK49677.1 - 3.8e-73 245.0 0.0 1.2e-72 243.4 0.0 1.9 2 0 0 2 2 2 1 Formiminotransferase domain, N-terminal subdomain FTCD_C PF04961.12 PIK49677.1 - 2.7e-66 222.8 0.3 5.2e-66 221.9 0.3 1.5 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase FTCD PF02971.14 PIK49677.1 - 2.1e-65 219.1 0.0 3.7e-65 218.4 0.0 1.4 1 0 0 1 1 1 1 Formiminotransferase domain FH2 PF02181.23 PIK49678.1 - 2e-48 165.4 9.4 1.8e-40 139.2 3.6 4.4 3 1 1 4 4 4 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 PIK49678.1 - 5.3e-27 94.7 9.9 1.8e-26 93.0 9.9 1.9 1 0 0 1 1 1 1 Diaphanous FH3 Domain Phage_GPO PF05929.11 PIK49678.1 - 0.79 9.3 14.9 0.19 11.3 5.9 2.3 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Drf_GBD PF06371.13 PIK49679.1 - 0.00083 19.0 0.1 0.00092 18.8 0.1 1.1 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Ricin_B_lectin PF00652.22 PIK49680.1 - 2.2e-20 73.2 0.7 3.3e-20 72.6 0.7 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 PIK49680.1 - 0.011 16.5 0.0 7.4 7.4 0.0 2.6 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Nyv1_N PF09426.10 PIK49680.1 - 0.082 12.9 0.4 0.33 11.0 0.1 2.0 2 0 0 2 2 2 0 Vacuolar R-SNARE Nyv1 N terminal Glycos_transf_2 PF00535.26 PIK49681.1 - 2.2e-23 82.9 0.6 4e-23 82.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 PIK49681.1 - 0.00011 21.8 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF1347 PF07079.11 PIK49681.1 - 0.08 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) Myosin_tail_1 PF01576.19 PIK49681.1 - 0.46 8.2 9.2 0.59 7.9 9.2 1.1 1 0 0 1 1 1 0 Myosin tail Integrin_alpha2 PF08441.12 PIK49683.1 - 3.9e-20 72.2 0.1 5.3e-20 71.8 0.1 1.1 1 0 0 1 1 1 1 Integrin alpha Integrin_alpha2 PF08441.12 PIK49684.1 - 1.5e-24 86.8 0.0 2e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK49684.1 - 6.3e-18 64.6 19.7 1.6e-08 34.5 0.5 4.4 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 PIK49684.1 - 2e-06 28.3 16.2 1.6e-05 25.4 3.4 3.8 1 1 4 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK49684.1 - 0.0022 18.2 4.8 0.0067 16.6 0.5 2.8 2 0 0 2 2 2 1 FG-GAP repeat DUF812 PF05667.11 PIK49685.1 - 9.3e-90 302.2 21.2 9.3e-90 302.2 21.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF812) Latarcin PF10279.9 PIK49685.1 - 0.00037 20.8 5.1 0.24 11.8 5.1 3.6 1 1 0 1 1 1 1 Latarcin precursor DUF948 PF06103.11 PIK49685.1 - 0.0035 17.6 11.2 0.82 10.0 0.1 4.8 2 1 1 4 4 4 1 Bacterial protein of unknown function (DUF948) ZapB PF06005.12 PIK49685.1 - 0.0063 16.9 1.7 0.0063 16.9 1.7 4.4 3 2 1 4 4 4 1 Cell division protein ZapB Hemerythrin PF01814.23 PIK49685.1 - 0.017 15.7 2.2 0.51 10.9 0.0 3.1 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain Mod_r PF07200.13 PIK49685.1 - 0.05 13.7 19.6 0.14 12.2 6.2 3.9 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF2203 PF09969.9 PIK49685.1 - 0.052 14.3 13.8 0.3 11.8 0.4 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Syntaxin_2 PF14523.6 PIK49685.1 - 0.096 13.1 21.5 1.5 9.3 8.1 3.8 2 1 1 3 3 3 0 Syntaxin-like protein Spectrin PF00435.21 PIK49685.1 - 0.15 12.6 15.8 1.2 9.7 0.6 3.5 1 1 3 4 4 4 0 Spectrin repeat PI3K_P85_iSH2 PF16454.5 PIK49685.1 - 0.25 10.9 21.0 0.3 10.7 14.8 3.3 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Fib_alpha PF08702.10 PIK49685.1 - 0.26 11.5 19.1 0.43 10.8 7.0 3.6 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 PIK49685.1 - 0.41 11.1 20.9 0.62 10.5 16.5 2.7 2 1 0 2 2 2 0 Fez1 Matrilin_ccoil PF10393.9 PIK49685.1 - 0.47 10.4 3.2 1.1 9.2 0.1 3.0 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Seryl_tRNA_N PF02403.22 PIK49685.1 - 0.74 10.1 26.8 1 9.6 2.6 4.2 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Peptidase_M75 PF09375.10 PIK49685.1 - 0.86 9.0 8.4 14 5.0 0.2 2.7 1 1 1 2 2 2 0 Imelysin DnaJ PF00226.31 PIK49685.1 - 0.93 9.7 5.1 29 4.9 1.8 3.4 2 1 0 2 2 2 0 DnaJ domain SKA2 PF16740.5 PIK49685.1 - 1.8 8.3 15.2 2.6 7.9 1.2 4.2 1 1 3 4 4 4 0 Spindle and kinetochore-associated protein 2 zf-C4H2 PF10146.9 PIK49685.1 - 1.9 8.7 19.8 2.1e+02 2.0 0.5 2.8 1 1 1 2 2 2 0 Zinc finger-containing protein YabA PF06156.13 PIK49685.1 - 2.2 8.9 20.1 50 4.6 0.9 4.0 1 1 2 3 3 3 0 Initiation control protein YabA Occludin_ELL PF07303.13 PIK49685.1 - 2.6 8.8 17.0 14 6.4 0.5 3.8 1 1 3 4 4 4 0 Occludin homology domain HALZ PF02183.18 PIK49685.1 - 2.8 8.3 0.0 2.8 8.3 0.0 5.2 6 0 0 6 6 6 0 Homeobox associated leucine zipper DUF4407 PF14362.6 PIK49685.1 - 4 6.7 14.4 1.5e+02 1.5 14.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 PIK49685.1 - 4.6 7.3 15.5 0.81 9.7 1.3 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Prominin PF05478.11 PIK49685.1 - 5.7 4.8 11.8 3.7 5.4 9.6 1.5 1 1 0 1 1 1 0 Prominin APC_N_CC PF16689.5 PIK49685.1 - 8.3 6.6 9.9 20 5.3 0.6 4.6 4 2 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain YtxH PF12732.7 PIK49685.1 - 8.7 7.0 10.2 1.3e+02 3.2 0.2 3.4 1 1 1 2 2 2 0 YtxH-like protein CENP-H PF05837.12 PIK49685.1 - 9.5 6.7 22.4 12 6.3 1.3 4.4 1 1 3 4 4 4 0 Centromere protein H (CENP-H) PWI PF01480.17 PIK49686.1 - 2.5e-07 30.9 0.1 3.9e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 PIK49686.1 - 3.1e-05 23.8 1.3 5.5e-05 23.0 1.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK49686.1 - 0.016 15.2 0.9 0.031 14.4 0.9 1.5 1 0 0 1 1 1 0 Zinc finger domain Gly_radical PF01228.21 PIK49687.1 - 0.03 14.9 0.4 0.068 13.7 0.4 1.6 1 0 0 1 1 1 0 Glycine radical Nup35_RRM_2 PF14605.6 PIK49688.1 - 2.5e-09 37.0 0.0 4.4e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Mus7 PF09462.10 PIK49688.1 - 1.7 7.4 6.3 0.074 11.9 1.0 1.3 2 0 0 2 2 2 0 Mus7/MMS22 family RRM_3 PF08777.11 PIK49688.1 - 8.1 6.6 8.7 0.63 10.1 0.1 3.1 2 1 0 3 3 3 0 RNA binding motif Mg_trans_NIPA PF05653.14 PIK49689.1 - 2.4e-117 391.3 24.8 3e-117 391.0 24.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 PIK49689.1 - 1.5e-05 25.1 6.0 1.5e-05 25.1 6.0 4.5 3 1 1 4 4 4 3 EamA-like transporter family EF-hand_1 PF00036.32 PIK49690.1 - 2.8e-32 107.8 17.8 4.1e-09 35.3 1.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 PIK49690.1 - 2.6e-28 98.2 10.9 1.4e-14 54.3 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK49690.1 - 1e-24 86.1 17.3 4.4e-12 45.7 0.9 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 PIK49690.1 - 2.4e-24 83.1 11.7 2.9e-09 36.1 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_9 PF14658.6 PIK49690.1 - 1.6e-15 57.1 0.6 1.3e-06 28.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK49690.1 - 5.1e-12 44.7 19.8 0.00036 19.9 0.3 4.6 4 1 1 5 5 5 4 EF hand EF-hand_4 PF12763.7 PIK49690.1 - 4.4e-05 23.4 8.6 0.075 13.0 1.5 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK49690.1 - 0.00027 21.2 1.1 0.19 12.0 0.5 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 PIK49690.1 - 0.00033 21.0 2.1 0.35 11.2 0.3 2.3 1 1 1 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 PIK49690.1 - 0.0024 18.0 0.6 0.22 11.7 0.1 2.5 2 1 0 2 2 2 1 Dockerin type I domain EF-hand_11 PF08976.11 PIK49690.1 - 0.0031 18.4 0.4 2 9.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain Sigma54_CBD PF04963.13 PIK49690.1 - 0.0058 16.5 0.2 0.008 16.1 0.2 1.2 1 0 0 1 1 1 1 Sigma-54 factor, core binding domain SurA_N_2 PF13623.6 PIK49690.1 - 0.023 14.6 3.2 4 7.3 0.1 2.8 1 1 2 3 3 3 0 SurA N-terminal domain SUB1_ProdP9 PF18213.1 PIK49690.1 - 0.033 14.0 0.5 0.081 12.8 0.3 1.6 1 1 0 1 1 1 0 SUB1 protease Prodomain ProdP9 DUF3349 PF11829.8 PIK49690.1 - 0.043 14.6 2.6 12 6.7 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) DUF853 PF05872.12 PIK49690.1 - 0.043 12.4 0.2 0.9 8.1 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) FlgD PF03963.14 PIK49690.1 - 0.044 14.1 0.2 0.14 12.5 0.1 1.9 2 0 0 2 2 2 0 Flagellar hook capping protein - N-terminal region TerB PF05099.13 PIK49690.1 - 0.065 13.2 2.0 1 9.3 0.1 2.4 1 1 1 2 2 2 0 Tellurite resistance protein TerB Pox_P35 PF03213.14 PIK49690.1 - 0.067 12.4 0.0 0.088 12.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein Caleosin PF05042.13 PIK49690.1 - 0.18 11.7 2.2 12 5.8 0.0 3.3 1 1 3 4 4 4 0 Caleosin related protein LETM1 PF07766.13 PIK49690.1 - 0.32 10.3 2.9 0.77 9.1 2.5 2.0 1 1 0 1 1 1 0 LETM1-like protein DUF21 PF01595.20 PIK49690.1 - 0.34 10.6 0.9 1.5 8.5 0.4 2.0 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain DUF3008 PF11450.8 PIK49690.1 - 0.43 10.8 0.1 0.43 10.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknwon function (DUF3008) Gp-FAR-1 PF05823.12 PIK49690.1 - 0.87 9.9 6.2 0.74 10.2 0.2 3.0 1 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1542 PF07564.11 PIK49690.1 - 4.9 7.3 7.7 16 5.7 0.1 2.9 4 0 0 4 4 3 0 Domain of Unknown Function (DUF1542) NDK PF00334.19 PIK49691.1 - 6e-52 175.2 0.0 6.8e-52 175.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Nexin_C PF08628.12 PIK49692.1 - 1.4e-23 83.6 0.5 1.1e-22 80.7 0.0 2.9 3 0 0 3 3 3 1 Sorting nexin C terminal RGS PF00615.19 PIK49692.1 - 4e-23 81.9 0.3 1.4e-22 80.1 0.3 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain PXA PF02194.15 PIK49692.1 - 9.1e-23 81.2 3.8 3.1e-13 50.1 0.0 3.3 2 1 1 3 3 3 2 PXA domain PX PF00787.24 PIK49692.1 - 8e-05 22.6 2.4 0.00027 20.9 0.3 2.9 3 0 0 3 3 3 1 PX domain DUF4131 PF13567.6 PIK49692.1 - 0.075 12.7 0.2 0.15 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Rad60-SLD_2 PF13881.6 PIK49693.1 - 2.1e-25 89.0 0.0 2.4e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 PIK49693.1 - 0.0024 17.6 0.0 0.0037 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 PIK49693.1 - 0.11 13.0 0.0 0.14 12.8 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain WD40 PF00400.32 PIK49694.1 - 3e-09 37.3 3.1 0.063 14.2 0.0 5.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49694.1 - 2.5e-07 30.9 0.0 1.9 8.8 0.0 5.4 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 PIK49694.1 - 0.022 13.3 0.0 0.044 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 PIK49694.1 - 0.027 14.4 0.6 2.1 8.4 0.0 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 PIK49694.1 - 0.03 13.6 0.4 15 4.8 0.1 3.6 4 0 0 4 4 4 0 WD40-like domain Pectate_lyase22 PF14583.6 PIK49694.1 - 0.084 11.5 0.1 0.38 9.4 0.1 1.8 1 1 1 2 2 2 0 Oligogalacturonate lyase Hira PF07569.11 PIK49694.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 TUP1-like enhancer of split Yip1 PF04893.17 PIK49695.1 - 0.0023 17.6 11.5 0.0035 17.1 11.5 1.3 1 1 0 1 1 1 1 Yip1 domain NKAIN PF05640.14 PIK49695.1 - 1.3 8.2 8.5 0.041 13.1 2.3 1.6 1 1 1 2 2 2 0 Na,K-Atpase Interacting protein UPF0139 PF03669.13 PIK49695.1 - 2.7 7.9 5.1 2.6 7.9 3.6 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0139) Ribosomal_L6 PF00347.23 PIK49697.1 - 1e-28 99.8 5.6 6.3e-16 58.8 1.9 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Yip1 PF04893.17 PIK49698.1 - 0.0046 16.7 0.0 0.006 16.3 0.0 1.1 1 0 0 1 1 1 1 Yip1 domain ERK-JNK_inhib PF15002.6 PIK49699.1 - 3.1e-32 111.8 0.4 4.8e-32 111.2 0.4 1.4 1 1 0 1 1 1 1 ERK and JNK pathways, inhibitor RCC1 PF00415.18 PIK49702.1 - 1.4e-19 70.4 0.5 1.8e-14 54.1 0.0 2.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK49702.1 - 9.3e-19 66.7 0.2 4.3e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat PHR PF08005.12 PIK49703.1 - 6.1e-49 166.6 0.0 1.1e-39 136.5 0.0 2.3 2 0 0 2 2 2 2 PHR domain DUF4082 PF13313.6 PIK49703.1 - 0.12 12.5 0.0 2.2 8.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4082) SH3_3 PF08239.11 PIK49704.1 - 9.4e-14 51.4 0.0 9.6e-07 29.0 0.0 2.7 2 0 0 2 2 2 2 Bacterial SH3 domain Filamin PF00630.19 PIK49704.1 - 3.5e-09 37.4 0.0 9.1e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat Invasin_D3 PF09134.10 PIK49704.1 - 0.0078 16.5 0.0 0.037 14.3 0.0 2.1 2 0 0 2 2 2 1 Invasin, domain 3 ANAPC10 PF03256.16 PIK49705.1 - 1.7e-07 31.0 0.1 3.2e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) tRNA-synt_His PF13393.6 PIK49706.1 - 5.1e-35 121.2 0.0 4.8e-23 81.9 0.0 2.9 3 0 0 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 PIK49706.1 - 2e-17 63.1 0.1 5e-17 61.8 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain WHEP-TRS PF00458.20 PIK49706.1 - 7.4e-16 58.1 3.7 2.6e-15 56.3 3.7 2.0 1 0 0 1 1 1 1 WHEP-TRS domain HGTP_anticodon2 PF12745.7 PIK49706.1 - 3.9e-07 29.9 0.0 1.5e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 PIK49706.1 - 7.9e-05 22.7 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 PIK49706.1 - 0.0034 16.5 0.0 0.011 14.8 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) BTB_2 PF02214.22 PIK49708.1 - 2.2e-10 40.8 0.0 6.4e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain RNB PF00773.19 PIK49709.1 - 2.2e-89 300.0 0.0 4.3e-89 299.1 0.0 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 PIK49709.1 - 4.6e-14 52.4 0.0 8.5e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 PIK49709.1 - 2.2e-08 34.0 0.3 6.3e-08 32.5 0.3 1.8 1 1 0 1 1 1 1 S1 domain PIN_4 PF13638.6 PIK49709.1 - 3.7e-08 33.7 0.0 8.8e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 PIN domain OB_Dis3 PF17849.1 PIK49709.1 - 1.9e-07 31.0 0.0 5.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) AAA_23 PF13476.6 PIK49710.1 - 1.6e-28 100.6 2.7 1.6e-28 100.6 2.7 4.4 1 1 2 3 3 3 1 AAA domain AAA_15 PF13175.6 PIK49710.1 - 7.6e-10 39.0 19.4 3.8e-09 36.7 0.0 3.0 1 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 PIK49710.1 - 6.6e-09 36.0 3.1 4.5e-05 23.4 0.0 3.1 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK49710.1 - 3.2e-07 30.0 23.2 9.9e-06 25.1 23.2 3.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 PIK49710.1 - 0.0092 15.7 0.8 3.9 7.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 PIK49710.1 - 0.05 14.0 1.4 0.22 11.9 0.0 2.6 3 1 0 3 3 3 0 AAA ATPase domain Coa1 PF08695.10 PIK49710.1 - 0.12 12.1 0.2 25 4.7 0.0 2.7 2 0 0 2 2 2 0 Cytochrome oxidase complex assembly protein 1 DUF3447 PF11929.8 PIK49710.1 - 1.8 8.6 5.7 0.72 9.9 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Plk4_PB1 PF18190.1 PIK49711.1 - 2.4e-41 140.3 0.0 5.2e-41 139.2 0.0 1.6 1 0 0 1 1 1 1 Polo-like Kinase 4 Polo Box 1 Plk4_PB2 PF18409.1 PIK49711.1 - 2.4e-33 115.1 0.0 1.4e-32 112.6 0.0 2.3 2 0 0 2 2 2 1 Polo-like Kinase 4 Polo Box 2 POLO_box PF00659.18 PIK49711.1 - 0.0022 18.2 0.1 0.01 16.0 0.0 2.2 2 0 0 2 2 2 1 POLO box duplicated region Phage_1_1 PF08200.11 PIK49711.1 - 2.9 8.4 8.5 0.31 11.5 3.9 1.8 2 0 0 2 2 2 0 Bacteriophage 1.1 Protein Pkinase PF00069.25 PIK49712.1 - 2.1e-28 99.4 3.4 6.5e-27 94.5 3.3 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49712.1 - 1.4e-17 63.8 2.8 2e-15 56.8 2.8 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK49712.1 - 0.013 14.3 0.1 0.023 13.5 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 PIK49712.1 - 0.19 11.1 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3591 PF12157.8 PIK49713.1 - 6.7e-154 512.8 0.0 1.2e-153 512.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) TBP-binding PF09247.11 PIK49713.1 - 6.4e-18 64.8 1.0 1.3e-17 63.8 1.0 1.5 1 0 0 1 1 1 1 TATA box-binding protein binding Bromodomain PF00439.25 PIK49714.1 - 9.1e-43 144.2 0.5 3.3e-20 71.9 0.0 2.6 2 0 0 2 2 2 2 Bromodomain zf-CCHC_6 PF15288.6 PIK49714.1 - 1.1e-09 37.9 2.3 2.7e-09 36.7 2.3 1.6 1 0 0 1 1 1 1 Zinc knuckle YecR PF13992.6 PIK49714.1 - 0.049 13.9 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 YecR-like lipoprotein APC_N_CC PF16689.5 PIK49714.1 - 0.16 12.0 1.9 0.2 11.8 0.1 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain zf-CCHC PF00098.23 PIK49714.1 - 0.41 10.8 1.9 1.1 9.5 1.9 1.8 1 0 0 1 1 1 0 Zinc knuckle DUF3847 PF12958.7 PIK49714.1 - 0.66 10.1 0.0 0.66 10.1 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3847) BTB_2 PF02214.22 PIK49715.1 - 3.6e-17 62.5 0.1 9e-17 61.2 0.1 1.6 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 PIK49715.1 - 1.3e-05 25.2 0.0 2.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DIL PF01843.19 PIK49716.1 - 0.21 11.9 1.3 0.41 11.0 0.2 2.1 2 0 0 2 2 2 0 DIL domain PH PF00169.29 PIK49718.1 - 8.6e-07 29.4 0.0 1.5e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 PH domain C2 PF00168.30 PIK49718.1 - 0.00095 19.4 0.1 0.0016 18.7 0.1 1.3 1 0 0 1 1 1 1 C2 domain PH_6 PF15406.6 PIK49718.1 - 0.0052 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Pet191_N PF10203.9 PIK49719.1 - 8.1e-23 80.5 6.2 1.6e-22 79.6 6.2 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 SDA1 PF05285.12 PIK49720.1 - 2.8e-47 161.9 38.5 2.4e-25 89.7 6.2 3.4 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 PIK49720.1 - 1.3e-15 57.4 0.1 3.7e-15 56.0 0.1 1.9 1 0 0 1 1 1 1 NUC130/3NT domain Aa_trans PF01490.18 PIK49721.1 - 2.8e-53 181.1 27.3 3.1e-41 141.4 21.9 2.8 2 1 1 3 3 3 2 Transmembrane amino acid transporter protein DUF1676 PF07898.13 PIK49721.1 - 0.044 13.8 0.1 0.044 13.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) AMP-binding PF00501.28 PIK49722.1 - 2.8e-96 322.7 0.5 1.8e-95 320.0 0.5 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK49722.1 - 1.2e-15 58.2 0.2 4.6e-15 56.3 0.1 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain TRP PF06011.12 PIK49723.1 - 0.0014 17.4 4.9 0.0014 17.4 4.9 2.2 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel Ion_trans PF00520.31 PIK49723.1 - 0.0021 17.3 1.5 0.0021 17.3 1.5 2.3 3 1 0 3 3 3 1 Ion transport protein AC_N PF16214.5 PIK49723.1 - 6 5.9 9.6 2.7 7.0 7.2 1.5 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Ephrin_rec_like PF07699.13 PIK49724.1 - 0.036 13.8 29.6 0.069 12.9 4.4 5.0 2 2 3 5 5 5 0 Putative ephrin-receptor like NCD3G PF07562.14 PIK49724.1 - 0.16 12.0 22.9 1 9.4 0.1 4.6 3 2 1 4 4 4 0 Nine Cysteines Domain of family 3 GPCR LRR_8 PF13855.6 PIK49725.1 - 3.4e-29 100.4 32.0 7.8e-11 41.6 1.7 4.4 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 PIK49725.1 - 1.4e-13 50.8 16.7 0.00024 21.4 0.2 5.3 3 3 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK49725.1 - 1.4e-05 25.1 0.2 0.14 12.1 0.1 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK49725.1 - 1.9e-05 24.2 0.3 0.0022 17.5 0.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK49725.1 - 0.0016 18.3 10.9 3.7 7.9 0.1 5.7 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 PIK49725.1 - 0.0039 17.5 12.5 15 6.6 0.0 6.5 8 0 0 8 8 8 1 Leucine Rich Repeat ACDC PF14733.6 PIK49725.1 - 0.019 15.3 0.0 0.031 14.6 0.0 1.4 1 0 0 1 1 1 0 AP2-coincident C-terminal LRR_8 PF13855.6 PIK49726.1 - 1.7e-12 46.9 6.8 6e-12 45.1 3.7 1.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 PIK49726.1 - 0.00042 20.3 0.0 0.00048 20.1 0.0 1.0 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK49726.1 - 0.0049 17.3 5.7 0.56 10.7 3.3 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LON_substr_bdg PF02190.16 PIK49727.1 - 4.2e-19 69.3 0.0 1e-18 68.0 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 PIK49727.1 - 6.3e-17 61.1 23.1 4.6e-11 42.4 7.1 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 PIK49727.1 - 4.4e-13 48.2 3.0 0.028 14.5 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK49727.1 - 5.3e-13 48.2 3.1 1.5e-05 24.6 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat zf-C3HC4 PF00097.25 PIK49727.1 - 7.5e-13 48.1 22.1 1.4e-06 28.0 6.3 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK49727.1 - 8.1e-13 48.5 24.1 4.7e-07 30.0 7.5 2.8 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_3 PF13920.6 PIK49727.1 - 4.6e-12 45.6 21.5 8.3e-07 28.8 7.1 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK49727.1 - 6.5e-12 45.3 36.3 3.9e-07 30.0 10.1 3.5 3 1 0 3 3 2 2 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK49727.1 - 1.9e-11 43.9 23.9 2.1e-05 24.6 8.2 3.0 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK49727.1 - 6e-10 38.9 23.3 6.4e-05 22.8 7.3 2.6 2 0 0 2 2 2 2 zinc-RING finger domain TPR_11 PF13414.6 PIK49727.1 - 2.2e-09 36.8 0.2 1.7e-05 24.4 0.1 4.0 3 1 1 4 4 4 1 TPR repeat Prok-RING_4 PF14447.6 PIK49727.1 - 5.7e-08 32.5 23.5 1.3e-05 25.0 8.3 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 TPR_16 PF13432.6 PIK49727.1 - 1.3e-06 29.0 2.8 0.11 13.1 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat zf-RING_10 PF16685.5 PIK49727.1 - 2.7e-06 27.4 21.4 0.00052 20.1 4.3 2.8 2 0 0 2 2 2 2 zinc RING finger of MSL2 TPR_8 PF13181.6 PIK49727.1 - 3.8e-06 26.7 0.6 0.0034 17.5 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK49727.1 - 1.4e-05 25.5 0.6 0.029 14.9 0.2 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK49727.1 - 0.00015 21.9 1.5 0.027 14.6 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK49727.1 - 0.0005 20.7 0.5 15 6.7 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF1258 PF06869.12 PIK49727.1 - 0.0081 15.7 2.6 0.7 9.3 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1258) U-box PF04564.15 PIK49727.1 - 0.014 15.5 0.0 1.3 9.3 0.0 2.8 2 0 0 2 2 2 0 U-box domain ANAPC3 PF12895.7 PIK49727.1 - 0.017 15.4 3.9 1.1 9.6 0.7 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK49727.1 - 0.021 14.8 2.1 89 3.5 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat zf-rbx1 PF12678.7 PIK49727.1 - 0.021 15.1 4.4 0.021 15.1 4.4 2.9 2 0 0 2 2 2 0 RING-H2 zinc finger domain TPR_17 PF13431.6 PIK49727.1 - 0.022 15.1 1.1 2.6 8.6 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK49727.1 - 0.042 14.2 0.8 29 5.1 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 PIK49727.1 - 0.091 12.6 16.8 1.3 8.8 3.5 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 PIK49727.1 - 0.13 11.6 0.1 0.13 11.6 0.1 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger Myelin_PLP PF01275.19 PIK49728.1 - 1.6e-19 70.8 14.7 5.5e-15 55.9 8.5 2.2 2 0 0 2 2 2 2 Myelin proteolipid protein (PLP or lipophilin) DUF3937 PF13073.6 PIK49728.1 - 0.064 13.4 1.4 1.4 9.1 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) DHHC PF01529.20 PIK49728.1 - 0.53 10.4 17.3 3.6 7.7 3.5 3.2 1 1 2 3 3 3 0 DHHC palmitoyltransferase TMEM192 PF14802.6 PIK49728.1 - 0.96 8.5 5.0 1 8.4 3.4 1.8 2 0 0 2 2 2 0 TMEM192 family DUF5090 PF17009.5 PIK49728.1 - 1.2 9.1 10.7 3.2 7.7 5.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5090) Phage_holin_3_6 PF07332.11 PIK49728.1 - 6.7 6.8 6.6 1.4 9.0 1.4 2.3 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III zf-rbx1 PF12678.7 PIK49729.1 - 3.9e-25 87.9 13.0 7.4e-25 87.0 13.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK49729.1 - 7.2e-17 61.2 10.0 1.1e-16 60.6 10.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 PIK49729.1 - 6.7e-06 26.3 14.7 0.00019 21.7 14.7 2.4 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK49729.1 - 0.00016 21.5 3.3 0.00016 21.5 3.3 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK49729.1 - 0.0047 16.8 11.9 0.063 13.2 11.9 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK49729.1 - 0.51 10.1 15.1 0.26 11.1 8.1 2.5 1 1 1 2 2 2 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 PIK49729.1 - 0.91 9.4 11.1 1.4 8.8 4.7 2.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 PIK49729.1 - 0.99 9.6 8.8 4.3 7.6 8.9 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 PIK49729.1 - 1.1 9.3 7.8 4.1 7.5 7.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 PIK49729.1 - 1.4 8.6 15.2 1.1e+02 2.6 15.2 2.4 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type PTCB-BRCT PF12738.7 PIK49730.1 - 4.9e-33 112.9 4.6 1.6e-20 72.8 0.3 2.7 3 0 0 3 3 3 2 twin BRCT domain BRCT PF00533.26 PIK49730.1 - 9.3e-30 102.8 1.5 9.2e-14 51.6 0.1 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK49730.1 - 6.9e-10 39.2 0.6 0.0011 19.4 0.1 2.7 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 PIK49730.1 - 6.2e-05 23.2 0.2 0.034 14.4 0.0 2.8 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain FAIM1 PF06905.13 PIK49731.1 - 1.9e-44 151.5 0.1 3.4e-23 82.2 0.0 2.0 1 1 1 2 2 2 2 Fas apoptotic inhibitory molecule (FAIM1) COesterase PF00135.28 PIK49732.1 - 4.6e-33 114.9 0.0 5e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK49732.1 - 0.00042 19.9 4.1 0.00075 19.1 4.1 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK49733.1 - 8.9e-60 203.0 2.1 5.9e-31 107.9 0.0 3.0 1 1 2 3 3 3 3 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK49733.1 - 6.4e-05 22.9 0.4 0.013 15.3 0.1 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK49733.1 - 0.0016 18.1 3.2 0.0016 18.1 3.2 2.0 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain TPR_1 PF00515.28 PIK49734.1 - 1.3e-13 50.1 0.2 6.8e-05 22.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK49734.1 - 4e-11 42.2 0.1 0.0096 16.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat CS PF04969.16 PIK49734.1 - 2.3e-08 35.0 0.1 6.1e-08 33.6 0.1 1.8 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.6 PIK49734.1 - 7.8e-07 28.7 0.1 0.008 15.8 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 PIK49734.1 - 1.3e-05 25.4 0.0 0.53 10.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK49734.1 - 0.00041 20.3 2.7 1.3 9.5 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK49734.1 - 0.0008 20.0 0.0 0.073 13.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK49734.1 - 0.0048 17.0 0.1 4.3 7.6 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK49734.1 - 0.025 15.0 1.6 1.3 9.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CSG2 PF16965.5 PIK49734.1 - 0.69 8.8 4.7 19 4.1 0.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator DUF4407 PF14362.6 PIK49734.1 - 1.1 8.6 9.7 1.5 8.1 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 PIK49734.1 - 2 5.8 19.8 2.8 5.4 19.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Presenilin PF01080.17 PIK49734.1 - 2.9 6.6 11.1 3.5 6.3 11.1 1.1 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 PIK49734.1 - 3.8 6.3 3.9 5.8 5.7 3.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF334 PF03904.13 PIK49734.1 - 4.8 6.7 15.0 7.8 6.0 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) PA26 PF04636.13 PIK49734.1 - 5.4 5.8 9.4 7.7 5.3 9.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Methyltransf_11 PF08241.12 PIK49735.1 - 2.2e-12 47.4 0.0 4.5e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK49735.1 - 2.9e-12 47.1 0.0 7.4e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK49735.1 - 1.4e-08 34.7 0.1 2.6e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK49735.1 - 9e-08 32.1 0.0 1.5e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 PIK49735.1 - 1.9e-07 30.0 0.0 2.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 PIK49735.1 - 5.5e-07 29.2 0.1 7.9e-07 28.7 0.1 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK49735.1 - 9.2e-06 26.3 1.2 7.3e-05 23.4 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain cwf18 PF08315.12 PIK49735.1 - 0.00036 21.2 1.4 0.00063 20.4 1.4 1.4 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor MTS PF05175.14 PIK49735.1 - 0.0014 18.2 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 PIK49735.1 - 0.0029 17.0 0.1 0.0068 15.8 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 PIK49735.1 - 0.0089 15.8 0.1 0.027 14.2 0.1 1.8 2 0 0 2 2 2 1 Lysine methyltransferase MetW PF07021.12 PIK49735.1 - 0.023 14.3 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DREV PF05219.12 PIK49735.1 - 0.085 11.9 0.0 0.16 11.1 0.0 1.6 1 1 0 1 1 1 0 DREV methyltransferase Methyltransf_18 PF12847.7 PIK49735.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 PIK49735.1 - 0.12 12.3 2.6 0.35 10.8 0.1 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK49736.1 - 8.8e-16 58.3 0.0 1.5e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK49736.1 - 1.9e-14 54.1 0.0 3.7e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK49736.1 - 1.9e-07 31.0 0.0 2.7e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK49736.1 - 3e-06 27.2 0.0 4.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 PIK49736.1 - 5.9e-05 21.8 0.0 7.5e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 PIK49736.1 - 5.9e-05 22.5 0.0 7.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK49736.1 - 0.0002 22.0 0.0 0.0004 21.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK49736.1 - 0.0003 20.4 0.0 0.00046 19.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 PIK49736.1 - 0.0038 16.9 0.0 0.0059 16.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 PIK49736.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 PIK49736.1 - 0.025 14.5 0.6 0.094 12.7 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.7 PIK49736.1 - 0.09 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 PIK49736.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DNA_III_psi PF03603.13 PIK49737.1 - 0.21 11.8 1.1 34 4.7 0.0 3.0 2 1 1 3 3 3 0 DNA polymerase III psi subunit Carb_anhydrase PF00194.21 PIK49738.1 - 4.7e-72 242.6 0.0 5.2e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase E1_DerP2_DerF2 PF02221.15 PIK49739.1 - 0.011 16.2 0.0 0.015 15.7 0.0 1.3 1 1 0 1 1 1 0 ML domain tRNA_m1G_MT PF01746.21 PIK49740.1 - 7.4e-30 104.1 0.1 1.2e-28 100.2 0.0 2.0 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase DUF4407 PF14362.6 PIK49740.1 - 0.56 9.5 3.7 0.84 8.9 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 5_nucleotid PF05761.14 PIK49740.1 - 2.2 7.1 6.0 3 6.6 6.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family V-set PF07686.17 PIK49741.1 - 2.9e-06 27.4 1.8 0.2 11.8 0.1 3.9 4 0 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK49741.1 - 7e-05 22.8 0.6 0.00039 20.4 0.3 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK49741.1 - 0.00085 19.9 0.4 5.1 7.8 0.1 3.8 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK49741.1 - 0.0011 19.1 0.6 12 6.2 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin domain DUF4448 PF14610.6 PIK49741.1 - 0.039 13.7 0.1 0.09 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 PIK49741.1 - 0.051 13.0 5.2 0.15 11.5 5.2 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF3377 PF11857.8 PIK49741.1 - 0.17 11.9 0.8 0.63 10.0 0.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM51 PF15345.6 PIK49741.1 - 0.6 9.9 2.7 0.49 10.2 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 Pkinase_Tyr PF07714.17 PIK49742.1 - 1.1e-32 113.4 0.0 1.3e-32 113.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49742.1 - 7.6e-12 45.1 0.0 8.4e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK49743.1 - 1.3e-12 47.8 0.4 0.00029 21.0 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK49743.1 - 1.8e-08 34.8 1.2 0.026 15.1 0.2 4.0 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK49743.1 - 2.2e-07 30.8 0.6 0.00048 20.2 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK49743.1 - 0.00061 19.8 1.7 0.0011 19.0 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK49743.1 - 0.013 15.7 0.3 7.8 6.7 0.0 3.7 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK49743.1 - 0.16 12.3 0.1 0.16 12.3 0.1 3.8 5 0 0 5 5 5 0 Immunoglobulin domain Dapper PF15268.6 PIK49743.1 - 0.2 10.5 9.1 0.27 10.1 9.1 1.0 1 0 0 1 1 1 0 Dapper Presenilin PF01080.17 PIK49743.1 - 4.3 6.0 6.8 7 5.3 6.8 1.3 1 0 0 1 1 1 0 Presenilin Pkinase_Tyr PF07714.17 PIK49744.1 - 1.8e-44 152.0 0.1 2.2e-44 151.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49744.1 - 4e-19 69.0 0.1 5.3e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain DED PF01335.21 PIK49745.1 - 8.4e-09 35.6 0.9 0.14 12.5 0.0 4.4 4 0 0 4 4 4 3 Death effector domain GCR1_C PF12550.8 PIK49745.1 - 0.056 13.8 1.4 7 7.0 0.5 3.4 3 0 0 3 3 3 0 Transcriptional activator of glycolytic enzymes V-set PF07686.17 PIK49746.1 - 4.2e-15 55.8 0.4 4.4e-05 23.6 0.1 3.9 4 0 0 4 4 4 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK49746.1 - 1e-09 38.8 1.5 0.027 15.1 0.0 5.6 6 0 0 6 6 6 2 Immunoglobulin domain ig PF00047.25 PIK49746.1 - 3.3e-05 24.0 2.0 0.99 9.6 0.1 5.3 6 0 0 6 6 6 2 Immunoglobulin domain I-set PF07679.16 PIK49746.1 - 0.00011 22.3 0.1 0.046 13.8 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin I-set domain Peptidase_M73 PF12389.8 PIK49746.1 - 0.12 12.2 0.1 10 5.9 0.0 2.7 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase Pkinase_Tyr PF07714.17 PIK49747.1 - 6.2e-28 97.8 0.0 8.8e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49747.1 - 1.7e-19 70.2 0.1 2.8e-19 69.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK49748.1 - 6.1e-10 39.6 1.9 0.0077 16.8 0.0 4.5 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK49748.1 - 2.5e-08 33.9 0.4 0.006 16.6 0.0 3.0 2 1 1 3 3 3 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK49748.1 - 7.6e-05 22.8 0.6 0.086 13.0 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK49748.1 - 0.0002 21.7 1.1 0.0046 17.3 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain I-set PF07679.16 PIK49748.1 - 0.0056 16.7 0.1 1.1 9.3 0.1 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 PIK49748.1 - 0.0065 16.6 0.3 0.086 13.0 0.1 2.8 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK49748.1 - 0.014 15.7 7.5 1.6 9.1 0.0 4.5 4 1 1 5 5 5 0 Immunoglobulin domain WAC_Acf1_DNA_bd PF10537.9 PIK49748.1 - 0.054 14.0 0.1 0.11 13.0 0.1 1.5 1 0 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal DUF2993 PF11209.8 PIK49748.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2993) NACHT PF05729.12 PIK49750.1 - 7.9e-13 48.6 0.0 2.8e-11 43.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain V-set PF07686.17 PIK49750.1 - 3e-07 30.6 0.3 0.038 14.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK49750.1 - 4.3e-07 30.2 0.8 0.42 11.0 0.0 4.8 3 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 PIK49750.1 - 1.3e-06 28.9 1.5 0.21 12.2 0.0 4.9 4 0 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK49750.1 - 0.00042 20.3 1.1 0.31 11.1 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DAP3 PF10236.9 PIK49750.1 - 0.0037 16.5 1.4 0.14 11.3 0.0 3.0 2 1 1 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK49750.1 - 0.018 15.3 0.0 0.065 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain I-set PF07679.16 PIK49750.1 - 0.026 14.6 0.4 13 6.0 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin I-set domain AAA_25 PF13481.6 PIK49750.1 - 0.029 14.0 0.0 0.081 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Izumo-Ig PF16706.5 PIK49750.1 - 0.037 14.1 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain AAA_19 PF13245.6 PIK49750.1 - 0.17 12.2 0.0 0.99 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain ig PF00047.25 PIK49750.1 - 1 9.6 8.7 47 4.3 0.5 4.5 3 1 1 4 4 4 0 Immunoglobulin domain 2OG-FeII_Oxy_3 PF13640.6 PIK49751.1 - 6.1e-11 43.1 0.0 1.1e-10 42.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 PIK49751.1 - 0.0019 18.7 0.1 0.0079 16.7 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 PIK49751.1 - 0.039 14.6 0.0 0.074 13.7 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C PF14853.6 PIK49753.1 - 1.9 8.6 9.7 9.8 6.3 0.5 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat RT_RNaseH_2 PF17919.1 PIK49754.1 - 8.3e-29 99.6 0.1 1.5e-28 98.7 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK49754.1 - 4.2e-24 84.9 0.0 9.1e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK49754.1 - 1.2e-08 34.7 0.0 2e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK49756.1 - 1.7e-05 24.6 16.1 0.003 17.5 3.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK49756.1 - 4.9e-05 23.1 6.2 0.0027 17.5 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK49756.1 - 0.00018 21.2 14.2 0.45 10.3 1.1 3.6 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK49756.1 - 1.6 9.1 12.4 0.52 10.6 6.9 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK49756.1 - 4.6 7.1 12.9 0.83 9.4 0.3 3.9 4 0 0 4 4 4 0 C2H2 zinc-finger zf-CCHC PF00098.23 PIK49757.1 - 0.00013 21.9 0.2 0.00036 20.5 0.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK49757.1 - 0.012 15.4 0.2 0.012 15.4 0.2 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK49757.1 - 0.056 13.4 0.1 0.15 12.1 0.1 1.8 1 0 0 1 1 1 0 Zinc knuckle FKBP_C PF00254.28 PIK49759.1 - 1.2e-34 118.5 0.0 1.5e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Nucleoporin_C PF03177.14 PIK49760.1 - 7.5e-31 107.5 10.7 1.5e-26 93.3 7.1 2.3 1 1 1 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 PIK49760.1 - 3.8e-17 62.2 0.8 5.8e-17 61.6 0.8 1.3 1 0 0 1 1 1 1 Nup133 N terminal like DYW_deaminase PF14432.6 PIK49760.1 - 0.16 11.8 0.1 0.39 10.6 0.1 1.6 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases Ribonuclease_T2 PF00445.18 PIK49761.1 - 2.3e-37 129.0 1.0 3e-37 128.6 1.0 1.0 1 0 0 1 1 1 1 Ribonuclease T2 family Eapp_C PF10238.9 PIK49762.1 - 1e-52 178.2 4.4 1e-52 178.2 4.4 1.8 2 1 0 2 2 2 1 E2F-associated phosphoprotein C1_4 PF07975.12 PIK49762.1 - 0.012 15.8 0.9 0.2 11.9 0.4 2.9 3 0 0 3 3 3 0 TFIIH C1-like domain IBR PF01485.21 PIK49762.1 - 0.014 15.6 1.3 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain PH_4 PF15404.6 PIK49762.1 - 1.3 8.8 7.4 0.86 9.4 1.6 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Yippee-Mis18 PF03226.14 PIK49762.1 - 1.7 8.9 5.7 24 5.2 5.9 2.4 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly FAM176 PF14851.6 PIK49762.1 - 3 7.5 8.1 0.54 9.9 1.1 2.6 3 0 0 3 3 3 0 FAM176 family Vps5 PF09325.10 PIK49763.1 - 1.3e-15 57.6 20.6 2.5e-14 53.4 15.6 2.7 2 1 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 PIK49763.1 - 5.3e-09 36.1 0.1 1.3e-08 34.8 0.1 1.7 1 0 0 1 1 1 1 PX domain Latarcin PF10279.9 PIK49763.1 - 0.0058 17.0 4.2 0.0058 17.0 4.2 2.6 2 0 0 2 2 2 1 Latarcin precursor SHOCT PF09851.9 PIK49763.1 - 0.056 13.2 0.8 0.056 13.2 0.8 2.3 2 0 0 2 2 2 0 Short C-terminal domain ChaC PF04752.12 PIK49764.1 - 7.4e-64 215.1 0.0 8.3e-64 214.9 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 PIK49764.1 - 1.8e-05 25.4 0.0 2.5e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK49764.1 - 0.0022 18.3 0.0 0.0032 17.8 0.0 1.3 1 0 0 1 1 1 1 AIG2-like family Phosphorylase PF00343.20 PIK49765.1 - 2.3e-40 138.6 0.1 2.8e-40 138.3 0.1 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Phosphorylase PF00343.20 PIK49766.1 - 8.1e-226 751.6 6.2 7.9e-196 652.5 0.2 2.0 1 1 1 2 2 2 2 Carbohydrate phosphorylase rpo132 PF12415.8 PIK49766.1 - 0.11 11.8 3.2 0.33 10.3 0.2 2.4 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase EGF PF00008.27 PIK49767.1 - 2.6e-64 213.1 191.2 2.9e-08 33.9 8.0 14.7 15 0 0 15 15 15 12 EGF-like domain hEGF PF12661.7 PIK49767.1 - 2e-46 155.1 152.9 2e-07 31.4 0.9 15.3 15 0 0 15 15 15 12 Human growth factor-like EGF EGF_CA PF07645.15 PIK49767.1 - 7.1e-23 80.5 189.4 0.00044 20.4 8.1 13.9 8 4 6 14 14 14 12 Calcium-binding EGF domain EGF_2 PF07974.13 PIK49767.1 - 1.3e-16 60.7 201.8 0.0024 18.2 9.4 14.0 13 0 0 13 13 13 9 EGF-like domain VWC PF00093.18 PIK49767.1 - 1.4e-05 25.3 7.0 1.4e-05 25.3 7.0 10.9 3 3 7 11 11 11 1 von Willebrand factor type C domain EGF_3 PF12947.7 PIK49767.1 - 0.00023 21.3 162.9 0.012 15.8 6.6 14.4 12 1 1 13 13 13 8 EGF domain cEGF PF12662.7 PIK49767.1 - 0.12 12.3 0.1 0.12 12.3 0.1 13.5 12 1 0 12 12 12 0 Complement Clr-like EGF-like Exo_endo_phos PF03372.23 PIK49768.1 - 1.8e-05 24.4 0.0 3.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK49768.1 - 0.00026 20.8 0.2 0.0013 18.6 0.0 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Histone PF00125.24 PIK49769.1 - 5.2e-29 101.3 7.4 2.8e-24 85.9 0.1 2.0 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK49769.1 - 0.001 19.2 0.0 0.0017 18.4 0.0 1.5 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 PIK49769.1 - 0.001 19.4 0.0 0.0015 18.9 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 PIK49769.1 - 0.008 16.8 4.6 0.01 16.4 4.6 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain Tap-RNA_bind PF09162.10 PIK49770.1 - 4.2e-28 97.0 0.1 8.3e-28 96.1 0.1 1.5 1 0 0 1 1 1 1 Tap, RNA-binding TAP_C PF03943.13 PIK49770.1 - 1.4e-21 75.8 0.0 3e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 PIK49770.1 - 7.3e-10 39.5 0.8 3.3e-09 37.4 0.8 2.0 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_9 PF14580.6 PIK49770.1 - 0.025 14.1 0.3 0.043 13.3 0.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_8 PF13855.6 PIK49770.1 - 0.094 12.5 8.4 0.32 10.8 8.4 2.0 1 1 1 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 PIK49770.1 - 4.9 7.7 10.9 9.5 6.8 6.7 2.5 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) NT-C2 PF10358.9 PIK49771.1 - 1.2e-12 47.8 0.0 2e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins FRG2 PF15315.6 PIK49771.1 - 1.1 9.5 5.6 2.2 8.4 5.6 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 CH PF00307.31 PIK49772.1 - 4.8e-08 33.2 0.4 1.7e-06 28.2 0.0 2.6 2 1 1 3 3 3 1 Calponin homology (CH) domain DUF3037 PF11236.8 PIK49772.1 - 0.06 13.8 2.3 0.14 12.6 2.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) DUF3525 PF12039.8 PIK49772.1 - 1.2 7.8 3.3 2.2 6.9 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) Vpu PF00558.19 PIK49772.1 - 2.3 8.0 4.9 4.8 7.0 3.9 2.2 1 1 0 1 1 1 0 Vpu protein DUF3585 PF12130.8 PIK49773.1 - 2.8e-37 127.9 18.8 4.7e-37 127.2 18.8 1.3 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain TF_Otx PF03529.13 PIK49774.1 - 0.0041 17.5 5.4 0.0041 17.5 5.4 1.7 1 1 0 1 1 1 1 Otx1 transcription factor Homeodomain PF00046.29 PIK49774.1 - 0.018 14.9 2.4 0.042 13.7 2.4 1.6 1 0 0 1 1 1 0 Homeodomain WBP-1 PF11669.8 PIK49774.1 - 0.025 15.2 1.9 0.028 15.1 0.7 1.6 1 1 1 2 2 2 0 WW domain-binding protein 1 Glyco_tran_10_N PF17039.5 PIK49775.1 - 1.8e-08 34.8 1.0 3.5e-08 33.9 0.1 1.8 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK49775.1 - 5.2e-07 29.6 0.0 8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term CART PF06373.11 PIK49775.1 - 0.37 11.0 1.3 0.5 10.6 0.0 1.7 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) LRR_6 PF13516.6 PIK49777.1 - 4.8e-19 66.7 17.8 2.4e-06 27.1 0.5 6.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_1 PF00560.33 PIK49777.1 - 9.1e-06 25.5 1.7 1.7 9.5 0.0 5.1 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 PIK49777.1 - 2.4e-05 24.6 9.2 0.002 18.5 2.0 3.8 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK49777.1 - 0.0011 18.7 14.2 0.69 9.7 0.4 4.5 1 1 3 4 4 4 3 Leucine rich repeat TIR_2 PF13676.6 PIK49779.1 - 6.7e-14 52.5 0.0 1.4e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 TIR domain DED PF01335.21 PIK49779.1 - 7.8e-09 35.7 3.9 0.0014 18.9 0.7 2.9 2 1 0 2 2 2 2 Death effector domain TIR PF01582.20 PIK49779.1 - 4.2e-05 23.4 0.2 7.5e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 TIR domain Death PF00531.22 PIK49779.1 - 0.0007 19.7 0.6 0.63 10.2 0.1 2.7 2 0 0 2 2 2 2 Death domain C2 PF00168.30 PIK49780.1 - 7.7e-15 55.0 1.4 4.5e-14 52.6 0.7 2.0 1 1 1 2 2 2 1 C2 domain Ac76 PF05814.11 PIK49780.1 - 0.073 13.1 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 Orf76 (Ac76) Pkinase PF00069.25 PIK49781.1 - 2.3e-13 50.1 0.0 2.7e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49781.1 - 3.3e-11 42.9 0.0 4.2e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK49781.1 - 0.00049 19.5 0.0 0.00071 19.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK49781.1 - 0.008 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.11 PIK49781.1 - 0.046 13.3 0.0 0.073 12.7 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) THUMP PF02926.17 PIK49782.1 - 1.4e-16 60.9 0.0 2.7e-16 60.0 0.0 1.5 1 1 0 1 1 1 1 THUMP domain Ig_3 PF13927.6 PIK49783.1 - 1.4e-05 25.5 0.5 0.0022 18.5 0.2 2.6 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK49783.1 - 5.4e-05 23.3 0.6 0.004 17.3 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49783.1 - 0.00011 22.5 0.9 0.0064 16.8 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain RIFIN PF02009.16 PIK49783.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Rifin DcuC PF03606.15 PIK49783.1 - 0.028 12.9 0.0 0.043 12.3 0.0 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Ig_3 PF13927.6 PIK49784.1 - 0.0055 17.3 0.0 0.031 14.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49784.1 - 0.052 13.9 0.7 0.14 12.5 0.1 2.1 2 0 0 2 2 2 0 Immunoglobulin domain Orthoreo_P10 PF07204.11 PIK49784.1 - 0.056 13.4 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 HEPN_AbiU2 PF18734.1 PIK49785.1 - 0.16 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 AbiU2 DIL PF01843.19 PIK49786.1 - 6.4e-06 26.4 0.2 1.2e-05 25.5 0.2 1.4 1 0 0 1 1 1 1 DIL domain HlyIII PF03006.20 PIK49787.1 - 7.2e-07 29.1 0.7 7.9e-07 29.0 0.7 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF5559 PF17714.1 PIK49787.1 - 0.15 12.0 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5559) IBR PF01485.21 PIK49789.1 - 3.3e-05 24.0 8.7 3.3e-05 24.0 8.7 3.6 1 1 2 3 3 3 1 IBR domain, a half RING-finger domain SIS PF01380.22 PIK49789.1 - 0.23 11.3 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 SIS domain zf-H2C2_5 PF13909.6 PIK49789.1 - 0.36 10.6 0.1 0.36 10.6 0.1 2.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-B_box PF00643.24 PIK49789.1 - 1.3 9.3 13.8 1.4 9.2 5.6 2.8 2 0 0 2 2 2 0 B-box zinc finger zf-C3HC4 PF00097.25 PIK49789.1 - 3.1 7.8 24.9 0.19 11.6 8.4 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Mito_carr PF00153.27 PIK49790.1 - 6.5e-43 144.6 2.4 4.9e-20 71.3 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein PhoPQ_related PF10142.9 PIK49791.1 - 9.7e-84 281.1 0.0 1.4e-83 280.5 0.0 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Glycos_transf_1 PF00534.20 PIK49791.1 - 2.4e-11 43.5 0.0 4.6e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK49791.1 - 1.9e-09 38.0 0.0 6.9e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 PIK49791.1 - 2.8e-05 24.2 0.0 6.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 PIK49791.1 - 0.0005 20.4 0.0 0.0014 18.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 AXE1 PF05448.12 PIK49791.1 - 0.002 16.8 0.0 0.0034 16.1 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) PhoPQ_related PF10142.9 PIK49792.1 - 2.4e-102 342.3 0.1 2.9e-102 342.1 0.1 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein AXE1 PF05448.12 PIK49792.1 - 0.035 12.8 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pep_M12B_propep PF01562.19 PIK49794.1 - 9.9e-29 100.4 0.0 3.6e-28 98.5 0.0 1.9 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin PF01421.19 PIK49794.1 - 9.2e-19 68.1 0.2 1.4e-18 67.5 0.2 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 PIK49794.1 - 1e-16 61.7 3.6 1e-16 61.7 3.6 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 PIK49794.1 - 2.4e-13 50.4 1.0 4.4e-13 49.6 1.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK49794.1 - 2e-11 44.5 0.4 4e-11 43.5 0.4 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like TSP_1 PF00090.19 PIK49794.1 - 1.1e-09 38.3 17.2 1.3e-06 28.5 0.8 4.1 4 0 0 4 4 4 2 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 PIK49794.1 - 5.2e-08 33.3 1.1 5.2e-08 33.3 1.1 2.9 3 1 0 3 3 3 1 ADAM cysteine-rich domain Reprolysin_4 PF13583.6 PIK49794.1 - 3e-07 30.3 4.8 6.7e-07 29.2 2.4 2.1 1 1 1 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK49794.1 - 0.027 14.3 0.1 0.041 13.7 0.1 1.4 1 0 0 1 1 1 0 Matrixin Sulfotransfer_2 PF03567.14 PIK49795.1 - 2.5e-17 63.6 0.3 3.5e-17 63.1 0.3 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK49795.1 - 2.4e-05 24.0 0.3 9.6e-05 22.0 0.3 1.8 1 1 0 1 1 1 1 Sulfotransferase domain Gal-3-0_sulfotr PF06990.11 PIK49795.1 - 0.0028 16.6 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK49796.1 - 8.6e-10 38.9 0.1 1.4e-09 38.3 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK49796.1 - 1.1e-07 31.7 0.5 3e-07 30.2 0.4 1.8 1 1 0 1 1 1 1 Sulfotransferase domain AAA_19 PF13245.6 PIK49796.1 - 0.019 15.3 0.0 0.033 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain DUF5371 PF17341.2 PIK49796.1 - 0.077 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5371) RT_RNaseH PF17917.1 PIK49797.1 - 1.5e-26 92.7 0.0 3.6e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK49797.1 - 1.5e-21 76.8 0.0 1.1e-20 74.0 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK49797.1 - 4.7e-20 71.5 0.3 2.2e-19 69.3 0.0 2.3 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK49797.1 - 3.4e-18 65.5 3.5 4.3e-18 65.2 2.2 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK49797.1 - 2.1e-06 27.8 1.7 1.3e-05 25.3 1.4 2.3 2 0 0 2 2 2 1 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK49797.1 - 0.01 16.1 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 DDE domain rve_3 PF13683.6 PIK49797.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain zf-H3C2 PF16721.5 PIK49797.1 - 0.013 15.8 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding HAT PF02184.16 PIK49797.1 - 0.36 10.8 1.5 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat RVT_1 PF00078.27 PIK49798.1 - 7.8e-29 100.8 0.0 1.2e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK49798.1 - 0.014 15.7 0.0 0.045 14.1 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK49798.1 - 0.054 14.1 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4722 PF15849.5 PIK49798.1 - 0.08 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) Asp_protease_2 PF13650.6 PIK49798.1 - 0.2 12.3 0.0 0.4 11.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease AAA_16 PF13191.6 PIK49801.1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ADAM_spacer1 PF05986.14 PIK49802.1 - 9.1e-21 74.0 0.2 1.6e-20 73.3 0.2 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 PIK49802.1 - 2.7e-19 69.4 24.2 1.1e-18 67.5 5.6 5.0 5 2 2 7 7 7 2 ADAM cysteine-rich domain TSP_1 PF00090.19 PIK49802.1 - 1.9e-17 63.2 67.1 8.3e-11 41.9 7.6 6.8 6 1 0 6 6 6 4 Thrombospondin type 1 domain Reprolysin PF01421.19 PIK49802.1 - 4.4e-08 33.3 0.1 7.2e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 PIK49802.1 - 5e-05 23.5 0.1 0.00014 22.1 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 PIK49802.1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 PIK49802.1 - 0.0053 16.4 0.0 0.016 14.8 0.0 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK49802.1 - 0.0055 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK49802.1 - 0.14 12.7 0.3 0.33 11.5 0.1 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK49802.1 - 0.28 10.4 0.5 0.44 9.7 0.5 1.2 1 0 0 1 1 1 0 Met-zincin PTR2 PF00854.21 PIK49803.1 - 1.6e-99 333.5 4.4 1.6e-99 333.5 4.4 1.6 2 0 0 2 2 2 1 POT family Mntp PF02659.15 PIK49803.1 - 0.04 13.7 0.1 0.04 13.7 0.1 2.5 2 0 0 2 2 2 0 Putative manganese efflux pump Gelsolin PF00626.22 PIK49804.1 - 4.8e-40 135.3 0.0 3.4e-15 55.7 0.0 3.1 3 0 0 3 3 3 3 Gelsolin repeat Gelsolin PF00626.22 PIK49805.1 - 7.9e-25 86.6 0.0 2e-11 43.6 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat MT-A70 PF05063.14 PIK49806.1 - 1.9e-52 177.7 0.0 3.2e-52 176.9 0.0 1.4 1 0 0 1 1 1 1 MT-A70 APC_basic PF05956.11 PIK49806.1 - 0.023 14.2 0.3 0.033 13.7 0.3 1.1 1 0 0 1 1 1 0 APC basic domain EF-hand_7 PF13499.6 PIK49807.1 - 6.2e-31 106.7 27.6 4.9e-07 30.1 0.4 7.9 7 1 0 7 7 7 6 EF-hand domain pair EF-hand_11 PF08976.11 PIK49807.1 - 3.9e-22 79.1 2.2 4.5e-07 30.7 0.0 6.5 6 0 0 6 6 6 4 EF-hand domain EF-hand_6 PF13405.6 PIK49807.1 - 1.1e-18 65.5 21.1 1.7e-05 24.3 0.0 11.6 14 0 0 14 14 14 4 EF-hand domain EF-hand_8 PF13833.6 PIK49807.1 - 3.7e-18 65.1 21.9 0.0027 17.5 0.3 9.4 9 1 1 10 10 10 5 EF-hand domain pair EF-hand_1 PF00036.32 PIK49807.1 - 1.6e-17 61.7 32.9 4.7e-06 25.8 0.0 12.5 15 0 0 15 15 15 7 EF hand EF-hand_5 PF13202.6 PIK49807.1 - 1.2e-05 24.5 8.9 0.75 9.4 0.0 8.2 9 0 0 9 9 9 2 EF hand DUF5580 PF17743.1 PIK49807.1 - 0.00011 20.9 0.3 0.75 8.3 0.1 3.3 2 1 0 2 2 2 2 Family of unknown function (DUF5580) SHOCT PF09851.9 PIK49807.1 - 0.12 12.2 1.0 16 5.4 0.1 3.2 2 0 0 2 2 2 0 Short C-terminal domain SPARC_Ca_bdg PF10591.9 PIK49807.1 - 7.3 7.0 11.1 14 6.0 0.0 4.9 5 0 0 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region baeRF_family11 PF18855.1 PIK49808.1 - 0.1 12.9 0.0 0.4 11.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 Ribonuc_2-5A PF06479.12 PIK49808.1 - 0.38 10.9 4.3 1.1 9.5 0.3 3.1 4 0 0 4 4 4 0 Ribonuclease 2-5A HECT PF00632.25 PIK49809.1 - 0.0047 16.5 0.0 0.0058 16.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ATP-gua_PtransN PF02807.15 PIK49809.1 - 0.064 13.7 0.0 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 ATP:guanido phosphotransferase, N-terminal domain CooC_C PF15976.5 PIK49809.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 CS1-pili formation C-terminal RVT_1 PF00078.27 PIK49810.1 - 7.9e-36 123.6 0.0 1e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK49813.1 - 3.6e-15 56.2 0.0 6e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 PIK49813.1 - 4e-09 36.2 0.5 1e-08 34.9 0.5 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 PIK49813.1 - 0.0081 16.0 0.2 0.026 14.4 0.2 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain rve_3 PF13683.6 PIK49813.1 - 0.11 12.2 0.9 0.28 11.0 0.2 2.0 2 0 0 2 2 2 0 Integrase core domain NUDIX PF00293.28 PIK49815.1 - 3.7e-12 46.4 0.0 1.3e-11 44.7 0.0 1.8 2 0 0 2 2 2 1 NUDIX domain Fez1 PF06818.15 PIK49816.1 - 0.0056 17.2 6.4 0.0077 16.7 6.4 1.2 1 0 0 1 1 1 1 Fez1 DUF16 PF01519.16 PIK49816.1 - 0.011 16.2 8.9 0.42 11.1 2.7 2.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 KELK PF15796.5 PIK49816.1 - 0.016 15.7 1.6 0.016 15.7 1.6 2.7 2 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF2730 PF10805.8 PIK49816.1 - 0.017 15.2 4.9 1.9 8.6 0.0 2.7 2 2 1 3 3 3 0 Protein of unknown function (DUF2730) KxDL PF10241.9 PIK49816.1 - 0.056 13.7 0.9 0.056 13.7 0.9 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF676 PF05057.14 PIK49816.1 - 0.069 12.7 0.7 0.19 11.2 0.2 2.1 2 1 0 2 2 2 0 Putative serine esterase (DUF676) DUF4776 PF16003.5 PIK49816.1 - 0.15 11.0 4.0 0.19 10.7 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) FlgN PF05130.12 PIK49816.1 - 0.24 11.9 4.9 0.38 11.3 2.8 2.2 2 1 0 2 2 2 0 FlgN protein DUF2232 PF09991.9 PIK49816.1 - 0.26 10.4 0.4 0.42 9.7 0.1 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) SKA2 PF16740.5 PIK49816.1 - 0.61 9.9 8.1 2.4 8.0 1.0 2.9 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Laminin_II PF06009.12 PIK49816.1 - 3.6 7.6 7.3 4.1 7.4 3.9 2.5 2 1 1 3 3 3 0 Laminin Domain II PvlArgDC PF01862.16 PIK49816.1 - 6 6.6 5.3 4 7.2 1.5 2.1 1 1 1 2 2 2 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Atg14 PF10186.9 PIK49816.1 - 9 5.3 8.9 11 5.0 7.8 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Aminotran_1_2 PF00155.21 PIK49817.1 - 2.9e-77 260.3 0.0 3.6e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.10 PIK49817.1 - 4e-12 46.6 1.9 4.7e-10 40.0 1.6 2.7 1 1 0 1 1 1 1 5-aminolevulinate synthase presequence Aminotran_5 PF00266.19 PIK49817.1 - 2.1e-07 30.3 0.1 3.8e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 PIK49817.1 - 1.6e-06 26.9 0.0 2.5e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme RNHCP PF12647.7 PIK49817.1 - 0.057 13.4 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 RNHCP domain RNA_polI_A34 PF08208.11 PIK49818.1 - 3.7e-09 37.0 0.2 3.7e-09 37.0 0.2 3.8 3 2 0 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 SIT PF15330.6 PIK49818.1 - 0.027 14.9 4.4 0.027 14.9 4.4 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Fn_bind PF02986.14 PIK49818.1 - 2 8.2 6.1 21 5.0 0.3 2.7 2 0 0 2 2 2 0 Fibronectin binding repeat DnaJ PF00226.31 PIK49819.1 - 8.2e-30 102.7 1.3 1e-29 102.4 1.3 1.1 1 0 0 1 1 1 1 DnaJ domain RepB_primase PF16793.5 PIK49819.1 - 0.095 12.8 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 RepB DNA-primase from phage plasmid YwhD PF08741.10 PIK49819.1 - 0.14 11.9 0.1 0.67 9.6 0.0 1.8 1 1 1 2 2 2 0 YwhD family LON_substr_bdg PF02190.16 PIK49820.1 - 0.0012 18.8 0.0 0.0014 18.5 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Yippee-Mis18 PF03226.14 PIK49821.1 - 3.5e-13 49.7 0.0 6.3e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LON_substr_bdg PF02190.16 PIK49821.1 - 7.6e-06 25.9 0.0 9.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C2H2_3rep PF18868.1 PIK49821.1 - 0.00094 19.9 0.1 0.025 15.3 0.0 2.3 2 0 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats SelR PF01641.18 PIK49821.1 - 0.058 13.5 0.0 13 5.9 0.0 2.3 2 0 0 2 2 2 0 SelR domain Filamin PF00630.19 PIK49822.1 - 0.0053 17.6 0.0 0.011 16.5 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat B-block_TFIIIC PF04182.12 PIK49823.1 - 4.2e-11 42.8 0.4 4.1e-09 36.5 0.1 3.3 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC BST2 PF16716.5 PIK49824.1 - 0.083 13.5 0.4 0.32 11.6 0.0 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 GAGBD PF16828.5 PIK49825.1 - 0.029 14.5 0.7 0.046 13.8 0.7 1.3 1 0 0 1 1 1 0 GAG-binding domain on surface antigen PP2C PF00481.21 PIK49827.1 - 3.2e-13 49.9 0.0 4.4e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 PIK49827.1 - 0.0031 17.4 0.0 0.0046 16.9 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) WD40 PF00400.32 PIK49828.1 - 2e-21 75.9 1.1 0.00011 22.9 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49828.1 - 8.1e-11 42.1 0.0 0.024 14.9 0.0 4.0 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 PIK49828.1 - 0.047 13.6 0.2 1.6 8.7 0.0 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Arylsulfotran_2 PF14269.6 PIK49828.1 - 0.066 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Nup160 PF11715.8 PIK49828.1 - 0.1 11.2 0.0 2 7.0 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF4147 PF13660.6 PIK49829.1 - 2.3e-72 243.2 1.9 3.8e-72 242.6 1.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 PIK49829.1 - 6.5e-34 116.4 1.0 1.3e-33 115.4 1.0 1.6 1 0 0 1 1 1 1 MOFRL family WD40 PF00400.32 PIK49830.1 - 4.5e-41 138.1 19.6 1.8e-08 34.9 0.5 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49830.1 - 3.7e-07 30.3 2.2 0.16 12.3 0.1 4.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 PIK49830.1 - 0.00078 18.3 0.2 1.7 7.3 0.0 3.5 1 1 3 4 4 4 2 Nup133 N terminal like Nup160 PF11715.8 PIK49830.1 - 0.0029 16.3 1.6 0.31 9.6 0.1 3.3 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Kinesin PF00225.23 PIK49831.1 - 2e-68 230.8 0.0 2e-68 230.8 0.0 2.5 2 2 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK49831.1 - 4.5e-14 52.6 3.4 1.4e-13 51.0 0.0 3.1 2 1 0 2 2 2 1 Microtubule binding Ribosomal_S3Ae PF01015.18 PIK49832.1 - 2.4e-92 308.1 4.2 2.9e-92 307.8 4.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family NLRC4_HD2 PF17776.1 PIK49832.1 - 0.0034 17.9 0.1 0.0051 17.3 0.1 1.2 1 0 0 1 1 1 1 NLRC4 helical domain HD2 Asparaginase_2 PF01112.18 PIK49833.1 - 3.9e-44 150.9 0.1 2.9e-31 108.6 0.1 2.9 2 1 0 2 2 2 2 Asparaginase Ig_3 PF13927.6 PIK49835.1 - 2.1e-09 37.9 0.5 4e-09 37.0 0.5 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK49835.1 - 9.2e-09 35.3 0.0 1.8e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK49835.1 - 2.9e-08 33.8 0.1 5.3e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49835.1 - 2.2e-05 24.7 1.5 3.1e-05 24.2 0.3 1.9 1 1 1 2 2 2 1 Immunoglobulin domain DUF5534 PF17686.1 PIK49835.1 - 0.028 14.7 0.4 0.046 14.0 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5534) ECSCR PF15820.5 PIK49835.1 - 0.031 14.1 1.7 0.051 13.4 0.3 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 PIK49835.1 - 0.054 14.4 0.0 0.11 13.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Sigma_reg_N PF13800.6 PIK49835.1 - 0.092 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal SIT PF15330.6 PIK49835.1 - 0.096 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Ig_3 PF13927.6 PIK49836.1 - 8.5e-10 39.1 0.1 2.6e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK49836.1 - 2.3e-09 37.3 0.0 6.1e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK49836.1 - 9.2e-09 35.3 0.0 2.3e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK49836.1 - 9.5e-05 22.7 0.1 0.00041 20.6 0.1 2.1 1 0 0 1 1 1 1 Immunoglobulin domain DUF1035 PF06281.12 PIK49836.1 - 0.0082 16.1 4.8 0.021 14.8 4.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1035) LRRCT PF01463.24 PIK49836.1 - 0.036 14.6 0.1 0.14 12.8 0.1 2.1 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain DUF4988 PF16378.5 PIK49836.1 - 0.1 12.2 0.0 1 9.0 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function LRR_8 PF13855.6 PIK49836.1 - 0.32 10.8 14.6 0.28 11.0 0.7 5.0 4 2 1 5 5 5 0 Leucine rich repeat Ig_3 PF13927.6 PIK49837.1 - 1.6e-07 31.8 0.1 5.7e-07 30.0 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK49837.1 - 3.1e-07 30.5 0.0 8.6e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK49837.1 - 7.4e-07 29.2 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK49837.1 - 0.0014 18.9 0.0 0.0069 16.7 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain AMA-1 PF02430.15 PIK49837.1 - 0.0016 17.5 0.4 0.0031 16.5 0.4 1.4 1 0 0 1 1 1 1 Apical membrane antigen 1 DUF1035 PF06281.12 PIK49837.1 - 0.014 15.4 1.1 0.04 13.9 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) ECSCR PF15820.5 PIK49837.1 - 0.044 13.6 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Insulin_TMD PF17870.1 PIK49837.1 - 0.4 10.8 1.9 0.79 9.8 1.9 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Sigma_reg_N PF13800.6 PIK49837.1 - 0.99 9.7 3.2 1.9 8.9 2.2 1.9 1 1 1 2 2 2 0 Sigma factor regulator N-terminal Pox_EPC_I2-L1 PF12575.8 PIK49837.1 - 1.1 9.6 4.4 0.29 11.4 0.7 1.9 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DEAD PF00270.29 PIK49838.1 - 2.8e-21 76.1 0.1 5.9e-21 75.0 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK49838.1 - 2.5e-19 69.6 0.1 5.8e-15 55.6 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 PIK49838.1 - 1.2e-08 35.5 2.2 1.2e-08 35.5 2.2 3.0 3 0 0 3 3 3 1 RecQ zinc-binding ResIII PF04851.15 PIK49838.1 - 1e-05 25.6 0.0 1e-05 25.6 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Folate_rec PF03024.14 PIK49839.1 - 1.3e-47 161.8 22.2 1.8e-47 161.4 22.2 1.1 1 0 0 1 1 1 1 Folate receptor family Kinesin PF00225.23 PIK49840.1 - 2.1e-105 352.3 0.0 2.1e-105 352.3 0.0 2.4 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK49840.1 - 1.3e-21 77.1 0.1 9.2e-21 74.3 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding DUF3800 PF12686.7 PIK49840.1 - 0.026 15.1 0.0 11 6.7 0.0 4.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF4239 PF14023.6 PIK49840.1 - 0.17 11.6 8.2 0.051 13.3 3.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4239) DUF4592 PF15262.6 PIK49842.1 - 0.00079 20.1 5.4 0.00079 20.1 5.4 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4592) Glyco_hydro_15 PF00723.21 PIK49843.1 - 1.6e-112 376.6 0.0 2.6e-112 375.9 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 PIK49844.1 - 7.8e-20 71.1 0.0 1.1e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 7tm_1 PF00001.21 PIK49846.1 - 3e-44 151.3 20.4 4.3e-44 150.8 20.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK49846.1 - 2.6e-15 56.8 13.4 2.6e-15 56.8 13.4 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK49846.1 - 3.7e-10 39.6 16.3 4.7e-10 39.3 16.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK49846.1 - 6.8e-09 35.5 14.8 3.5e-08 33.2 14.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK49846.1 - 0.068 12.9 19.3 0.11 12.3 14.1 2.2 2 1 0 2 2 2 0 Olfactory receptor Septin PF00735.18 PIK49846.1 - 0.17 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Septin Fibrinogen_C PF00147.18 PIK49847.1 - 4.7e-43 147.6 2.2 7.6e-43 146.9 2.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK49847.1 - 3.1e-07 30.5 9.7 9.2e-07 29.0 9.7 1.8 1 0 0 1 1 1 1 EGF domain EGF_MSP1_1 PF12946.7 PIK49847.1 - 0.01 15.9 6.1 0.01 15.9 6.1 1.9 2 0 0 2 2 2 0 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK49847.1 - 0.027 14.8 6.0 0.072 13.4 6.0 1.8 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_2 PF07974.13 PIK49847.1 - 0.69 10.3 8.3 2.6 8.5 8.3 2.0 1 0 0 1 1 1 0 EGF-like domain cEGF PF12662.7 PIK49847.1 - 4.3 7.4 11.0 0.24 11.3 4.9 2.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like LXG PF04740.12 PIK49848.1 - 0.0085 15.8 2.3 0.013 15.2 0.4 1.8 1 1 1 2 2 2 2 LXG domain of WXG superfamily Sec20 PF03908.13 PIK49848.1 - 0.014 15.3 0.8 0.014 15.3 0.8 1.8 2 0 0 2 2 2 0 Sec20 SLATT_6 PF18169.1 PIK49848.1 - 0.033 13.8 0.8 0.045 13.4 0.8 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF334 PF03904.13 PIK49848.1 - 0.057 13.0 5.4 0.077 12.5 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) ALMT PF11744.8 PIK49848.1 - 0.087 11.6 1.7 0.11 11.3 1.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec34 PF04136.15 PIK49848.1 - 0.67 9.8 5.7 0.18 11.7 1.1 1.8 2 1 1 3 3 3 0 Sec34-like family Cauli_AT PF03233.13 PIK49848.1 - 0.72 9.8 3.9 1.1 9.1 3.9 1.2 1 0 0 1 1 1 0 Aphid transmission protein TMPIT PF07851.13 PIK49848.1 - 1 8.5 3.4 1.5 8.0 3.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1758 PF05585.12 PIK49849.1 - 0.004 17.0 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 PIK49849.1 - 0.02 15.5 0.0 0.046 14.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 PIK49849.1 - 0.064 13.8 0.0 0.3 11.7 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease 7tm_1 PF00001.21 PIK49850.1 - 1.2e-31 110.1 10.9 1.6e-31 109.6 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK49850.1 - 7.1e-08 32.4 16.7 1.8e-07 31.0 16.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK49850.1 - 0.0012 18.3 13.4 0.11 11.8 0.1 3.0 2 2 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK49850.1 - 0.0061 15.9 12.7 0.024 13.9 12.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 PIK49850.1 - 0.0066 16.2 8.1 0.0066 16.2 8.1 2.0 2 0 0 2 2 2 1 Olfactory receptor 7tm_1 PF00001.21 PIK49851.1 - 2.8e-19 69.5 10.0 4.4e-19 68.8 10.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK49851.1 - 5e-07 29.6 10.6 5e-07 29.6 10.6 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx UPF0542 PF15086.6 PIK49851.1 - 0.018 15.0 1.0 0.096 12.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF996 PF06195.13 PIK49851.1 - 7.7 6.8 9.3 11 6.3 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF996) EGF_2 PF07974.13 PIK49852.1 - 0.0085 16.4 9.9 0.0085 16.4 9.9 6.7 6 1 0 6 6 6 3 EGF-like domain YccV-like PF08755.11 PIK49853.1 - 0.16 12.5 0.3 0.39 11.2 0.2 1.6 2 0 0 2 2 2 0 Hemimethylated DNA-binding protein YccV like Pkinase_Tyr PF07714.17 PIK49854.1 - 3.6e-28 98.6 0.0 5.1e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49854.1 - 4.9e-22 78.6 0.0 1.3e-21 77.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain DUF2054 PF10218.9 PIK49854.1 - 0.076 13.1 0.3 0.14 12.3 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) Kdo PF06293.14 PIK49854.1 - 0.14 11.5 0.1 0.32 10.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Galactosyl_T PF01762.21 PIK49855.1 - 5.1e-10 39.5 0.0 7.7e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase DUF3612 PF12268.8 PIK49855.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3612) CotJA PF11007.8 PIK49856.1 - 0.005 16.6 0.0 3 7.7 0.0 4.1 5 0 0 5 5 5 2 Spore coat associated protein JA (CotJA) Ig_2 PF13895.6 PIK49858.1 - 2.8e-07 30.8 0.2 2.8e-07 30.8 0.2 2.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK49858.1 - 0.002 18.7 1.4 0.0075 16.8 0.4 2.5 2 0 0 2 2 2 1 Immunoglobulin domain EpoR_lig-bind PF09067.10 PIK49858.1 - 0.0037 17.5 1.0 0.011 15.9 1.0 1.8 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding I-set PF07679.16 PIK49858.1 - 0.043 13.9 0.1 0.45 10.6 0.0 2.7 2 1 0 2 2 2 0 Immunoglobulin I-set domain ig PF00047.25 PIK49858.1 - 0.14 12.3 6.0 0.37 11.0 0.2 3.8 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK49859.1 - 7.4e-07 29.4 3.7 4.2e-06 27.0 0.2 2.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK49859.1 - 8.7e-06 26.3 0.7 2.5e-05 24.8 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK49859.1 - 0.0021 18.2 0.2 0.0059 16.8 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK49859.1 - 0.0044 17.2 1.1 2.4 8.4 0.1 2.6 1 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK49859.1 - 0.024 14.7 0.1 0.083 13.0 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin I-set domain fn3 PF00041.21 PIK49859.1 - 0.059 13.7 0.1 0.17 12.2 0.1 1.9 1 0 0 1 1 1 0 Fibronectin type III domain Apt1 PF10351.9 PIK49860.1 - 0.035 13.0 3.9 0.04 12.8 3.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sulfotransfer_2 PF03567.14 PIK49861.1 - 4.5e-35 121.8 0.2 7.8e-35 121.0 0.1 1.4 1 1 0 1 1 1 1 Sulfotransferase family GCR1_C PF12550.8 PIK49861.1 - 0.13 12.6 0.2 2.9 8.3 0.1 2.6 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Stevor PF17410.2 PIK49862.1 - 0.0097 15.5 0.5 0.015 14.9 0.5 1.2 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Amnionless PF14828.6 PIK49862.1 - 0.03 13.2 0.6 0.041 12.7 0.6 1.2 1 0 0 1 1 1 0 Amnionless DUF5412 PF17428.2 PIK49862.1 - 0.031 14.1 0.1 0.077 12.9 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5412) ECSCR PF15820.5 PIK49862.1 - 0.048 13.5 1.3 0.075 12.9 0.3 1.8 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 PIK49862.1 - 0.06 14.2 0.1 0.13 13.1 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK49862.1 - 0.073 13.0 2.0 0.17 11.8 2.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family Lep_receptor_Ig PF06328.11 PIK49862.1 - 0.082 12.9 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 Ig-like C2-type domain DUF5385 PF17359.2 PIK49862.1 - 0.13 11.8 0.6 0.2 11.2 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) SRCR PF00530.18 PIK49863.1 - 2.8e-52 175.4 2.4 4.8e-27 94.4 0.7 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK49863.1 - 1.9e-11 44.3 1.0 0.00013 22.4 0.0 2.5 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK49863.1 - 1.1e-05 25.9 0.1 0.11 13.0 0.0 3.0 2 1 0 2 2 2 2 Hepsin, SRCR domain SRCR PF00530.18 PIK49864.1 - 0 1710.0 143.8 7.3e-31 106.6 2.0 18.2 18 0 0 18 18 18 18 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK49864.1 - 9.1e-106 346.8 56.2 2.2e-05 24.9 0.1 18.5 18 0 0 18 18 18 18 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK49864.1 - 1.4e-57 192.9 11.6 0.1 13.1 0.0 18.5 18 0 0 18 18 18 18 Hepsin, SRCR domain Chitin_bind_1 PF00187.19 PIK49864.1 - 6.8e-19 68.0 130.7 0.0045 17.4 12.4 11.9 9 0 0 9 9 9 6 Chitin recognition protein Viral_P18 PF04521.13 PIK49864.1 - 0.67 9.7 8.1 12 5.7 0.0 4.5 4 0 0 4 4 4 0 ssRNA positive strand viral 18kD cysteine rich protein Bac_chlorC PF02043.17 PIK49864.1 - 2.1 8.4 28.4 13 5.9 0.0 9.5 11 0 0 11 11 11 0 Bacteriochlorophyll C binding protein SRCR PF00530.18 PIK49865.1 - 9.1e-263 850.8 67.3 5.8e-30 103.8 0.8 9.2 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK49865.1 - 1.5e-55 185.7 21.1 5.4e-05 23.7 0.0 9.4 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK49865.1 - 6.4e-24 84.6 11.6 0.11 13.0 0.0 9.8 11 0 0 11 11 11 8 Hepsin, SRCR domain AMIN PF11741.8 PIK49865.1 - 0.0004 20.4 0.3 20 5.4 0.0 5.7 6 0 0 6 6 6 1 AMIN domain REGB_T4 PF10715.9 PIK49865.1 - 0.0017 18.6 1.2 12 6.1 0.0 4.7 5 0 0 5 5 5 2 T4-page Endoribonuclease RegB Bacteroid_pep PF14406.6 PIK49865.1 - 0.92 9.9 5.6 21 5.6 0.2 3.1 3 0 0 3 3 3 0 Ribosomally synthesized peptide in Bacteroidetes Yip1 PF04893.17 PIK49867.1 - 1.1e-11 44.7 14.5 5e-11 42.6 14.7 1.8 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 PIK49867.1 - 0.66 9.4 13.4 5.2 6.5 6.9 2.8 1 1 1 2 2 2 0 YIF1 Hemopexin PF00045.19 PIK49868.1 - 1.8e-25 88.6 9.3 4.3e-14 52.2 1.1 3.2 3 0 0 3 3 3 3 Hemopexin PetN PF03742.14 PIK49868.1 - 0.079 12.8 0.8 0.14 12.1 0.8 1.4 1 0 0 1 1 1 0 PetN Gal-3-0_sulfotr PF06990.11 PIK49869.1 - 8.6e-104 347.6 3.4 1.6e-54 185.4 0.2 2.1 2 0 0 2 2 2 2 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK49869.1 - 1e-09 38.7 2.6 0.0017 18.3 0.3 4.1 3 2 0 3 3 3 2 Sulfotransferase family DDE_Tnp_4 PF13359.6 PIK49869.1 - 0.0017 18.0 0.0 0.77 9.4 0.0 2.4 2 0 0 2 2 2 2 DDE superfamily endonuclease LRR_9 PF14580.6 PIK49870.1 - 2.2e-15 56.6 0.1 2.9e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 PIK49870.1 - 3.2e-10 39.6 3.0 2e-09 37.1 1.8 2.6 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 PIK49870.1 - 5.6e-08 33.0 2.8 0.00013 22.3 0.4 3.3 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK49871.1 - 2.2e-15 56.6 0.1 2.9e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 PIK49871.1 - 3.2e-10 39.6 3.0 2e-09 37.1 1.8 2.6 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 PIK49871.1 - 5.6e-08 33.0 2.8 0.00013 22.3 0.4 3.3 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) UPF0061 PF02696.14 PIK49873.1 - 3.6e-14 52.4 0.0 7.4e-14 51.4 0.0 1.4 2 0 0 2 2 2 1 Uncharacterized ACR, YdiU/UPF0061 family UPF0061 PF02696.14 PIK49874.1 - 6e-57 193.5 0.1 6.8e-57 193.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family RBD-FIP PF09457.10 PIK49874.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 FIP domain mRNA_cap_enzyme PF01331.19 PIK49875.1 - 3.9e-48 163.9 2.6 2.4e-27 96.0 0.3 2.5 2 1 1 3 3 3 2 mRNA capping enzyme, catalytic domain DSPc PF00782.20 PIK49875.1 - 4.5e-13 49.2 0.3 1.1e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain mRNA_cap_C PF03919.15 PIK49875.1 - 2.5e-10 40.9 0.0 5.6e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain Y_phosphatase PF00102.27 PIK49875.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Pkinase PF00069.25 PIK49877.1 - 2.6e-52 177.8 0.0 7.8e-52 176.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49877.1 - 9.2e-23 80.8 0.0 2.6e-22 79.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.7 PIK49877.1 - 5.7e-12 45.8 0.0 0.0077 16.5 0.0 3.8 4 0 0 4 4 4 3 PAS domain PAS PF00989.25 PIK49877.1 - 1.7e-10 40.9 0.0 5.1e-05 23.2 0.0 3.5 3 0 0 3 3 3 2 PAS fold Kinase-like PF14531.6 PIK49877.1 - 3.5e-07 29.8 0.0 5.7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PAS_8 PF13188.7 PIK49877.1 - 2e-05 24.5 0.0 0.16 12.0 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 PIK49877.1 - 0.00044 20.5 0.0 6.9 7.0 0.0 3.8 3 0 0 3 3 3 1 PAS fold Pkinase_fungal PF17667.1 PIK49877.1 - 0.0019 17.1 0.0 0.0039 16.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK49877.1 - 0.012 15.6 0.0 0.32 10.9 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK49877.1 - 0.051 12.9 0.0 0.099 12.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_7 PF12860.7 PIK49877.1 - 0.07 13.3 0.0 17 5.6 0.0 2.9 3 0 0 3 3 3 0 PAS fold Thioredoxin PF00085.20 PIK49878.1 - 1.4e-57 192.0 0.0 8.2e-28 96.4 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 PIK49878.1 - 5.5e-07 30.0 0.4 0.063 13.7 0.0 4.4 3 2 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 PIK49878.1 - 1.1e-05 25.0 0.0 0.1 11.9 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 PIK49878.1 - 5.4e-05 23.2 0.0 0.016 15.1 0.0 3.2 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK49878.1 - 0.00013 22.3 0.0 0.99 9.8 0.0 3.5 3 2 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 PIK49878.1 - 0.00028 21.0 0.0 0.36 11.1 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 PIK49878.1 - 0.00058 19.8 0.1 0.43 10.5 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_3 PF13192.6 PIK49878.1 - 0.0029 17.6 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin domain HyaE PF07449.11 PIK49878.1 - 0.009 16.0 0.0 36 4.4 0.0 3.3 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE MT0933_antitox PF14013.6 PIK49878.1 - 0.0092 16.3 1.5 0.051 13.9 0.6 2.3 2 0 0 2 2 2 1 MT0933-like antitoxin protein Thioredoxin_9 PF14595.6 PIK49878.1 - 0.011 15.4 0.0 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin DDE_Tnp_1_2 PF13586.6 PIK49878.1 - 0.13 12.7 0.0 17 5.9 0.0 2.4 2 0 0 2 2 2 0 Transposase DDE domain zf-U11-48K PF05253.12 PIK49879.1 - 2.1e-15 56.2 10.6 1.1e-09 37.9 1.0 2.5 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger PAN_1 PF00024.26 PIK49880.1 - 1.4e-22 79.4 23.2 3.1e-09 36.6 2.0 3.1 2 1 1 3 3 3 3 PAN domain PAN_4 PF14295.6 PIK49880.1 - 0.017 15.1 3.4 0.017 15.1 3.4 4.1 3 2 0 3 3 3 0 PAN domain PAN_3 PF08277.12 PIK49880.1 - 0.65 9.9 18.9 0.31 10.9 0.8 3.5 3 1 0 3 3 3 0 PAN-like domain PAN_1 PF00024.26 PIK49881.1 - 1.2e-22 79.6 20.9 4.2e-09 36.2 3.0 3.1 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 PIK49881.1 - 0.037 13.9 4.4 0.037 13.9 4.4 4.0 3 2 0 3 3 3 0 PAN domain PAN_3 PF08277.12 PIK49881.1 - 0.12 12.2 16.1 0.3 10.9 0.6 3.6 3 1 0 3 3 3 0 PAN-like domain PAN_1 PF00024.26 PIK49882.1 - 1.4e-21 76.3 19.3 3.9e-08 33.2 1.8 3.2 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 PIK49882.1 - 0.32 10.9 19.7 0.07 13.1 4.6 3.8 3 1 0 3 3 3 0 PAN domain HYR PF02494.16 PIK49883.1 - 5.1e-19 68.4 8.9 9.3e-08 32.3 0.3 3.5 3 0 0 3 3 3 3 HYR domain PAN_1 PF00024.26 PIK49884.1 - 3.6e-16 58.9 22.1 4.1e-07 29.9 4.5 3.2 2 1 1 3 3 3 3 PAN domain PAN_4 PF14295.6 PIK49884.1 - 0.018 14.9 4.1 0.018 14.9 4.1 3.8 3 1 0 3 3 3 0 PAN domain DUF2119 PF09892.9 PIK49884.1 - 0.19 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) PAN_3 PF08277.12 PIK49884.1 - 4.2 7.3 16.2 0.73 9.7 0.5 3.7 3 1 0 3 3 3 0 PAN-like domain ABC_tran PF00005.27 PIK49886.1 - 3e-22 79.6 0.0 4.8e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter DUF87 PF01935.17 PIK49886.1 - 0.00011 22.3 0.1 0.00019 21.6 0.1 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 PIK49886.1 - 0.0002 21.0 0.0 0.00037 20.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 PIK49886.1 - 0.00066 20.2 0.0 0.00099 19.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 PIK49886.1 - 0.0057 15.7 0.0 0.0075 15.4 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 PIK49886.1 - 0.0097 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 PIK49886.1 - 0.011 14.6 0.1 0.022 13.7 0.1 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.23 PIK49886.1 - 0.015 15.3 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 PIK49886.1 - 0.026 14.8 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 PIK49886.1 - 0.031 14.0 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 PIK49886.1 - 0.036 13.1 0.0 0.056 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 PIK49886.1 - 0.04 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Pox_A32 PF04665.12 PIK49886.1 - 0.057 12.9 0.3 1 8.8 0.1 2.2 1 1 1 2 2 2 0 Poxvirus A32 protein AAA_21 PF13304.6 PIK49886.1 - 0.079 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 PIK49886.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 PIK49886.1 - 0.11 12.8 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.18 PIK49886.1 - 0.17 11.6 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 PIK49886.1 - 0.19 11.4 0.0 0.59 9.8 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_membrane PF00664.23 PIK49887.1 - 2.4e-19 70.0 0.8 3.9e-19 69.3 0.7 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region Ins145_P3_rec PF08709.11 PIK49888.1 - 3.1e-83 278.2 0.0 6.9e-82 273.8 0.0 2.5 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 PIK49888.1 - 2e-65 220.1 0.0 8.6e-64 214.8 0.0 2.4 2 0 0 2 2 2 1 MIR domain RYDR_ITPR PF01365.21 PIK49888.1 - 1.5e-56 191.1 1.5 2.4e-56 190.4 1.5 1.3 1 0 0 1 1 1 1 RIH domain Ion_trans PF00520.31 PIK49889.1 - 3.5e-15 55.9 8.0 1.4e-14 53.9 8.0 2.2 1 1 0 1 1 1 1 Ion transport protein RIH_assoc PF08454.11 PIK49889.1 - 1.8e-11 43.8 23.4 2.7e-10 40.0 0.4 6.2 4 2 2 6 6 6 2 RyR and IP3R Homology associated RYDR_ITPR PF01365.21 PIK49889.1 - 5.5e-08 32.5 14.8 1e-06 28.4 9.0 4.8 4 1 0 4 4 4 1 RIH domain DUF2207 PF09972.9 PIK49889.1 - 1.7 7.3 9.8 1.5 7.5 0.1 3.6 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF16 PF01519.16 PIK49889.1 - 4.8 7.7 10.7 7.9 7.0 2.1 4.0 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF4551 PF15087.6 PIK49890.1 - 1.2e-41 143.3 22.0 5.5e-41 141.1 22.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF4551) Sec20 PF03908.13 PIK49890.1 - 1.5 8.8 6.0 0.21 11.5 0.7 2.3 2 0 0 2 2 2 0 Sec20 DUF4551 PF15087.6 PIK49891.1 - 5.1e-61 207.3 3.2 6.1e-61 207.0 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) p450 PF00067.22 PIK49892.1 - 7.5e-120 400.8 0.0 8.7e-120 400.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUSP PF06337.12 PIK49892.1 - 0.094 13.3 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 DUSP domain p450 PF00067.22 PIK49893.1 - 2.2e-22 79.4 0.0 2.7e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUSP PF06337.12 PIK49893.1 - 0.13 12.9 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 DUSP domain GN3L_Grn1 PF08701.11 PIK49894.1 - 4.6e-21 74.7 27.9 4.6e-21 74.7 27.9 2.7 3 0 0 3 3 3 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 PIK49894.1 - 2.5e-09 37.2 0.1 4.7e-07 29.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK49894.1 - 1.3e-07 31.3 0.2 0.0062 16.1 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK49894.1 - 0.00031 20.7 0.3 0.61 10.0 0.1 2.5 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 PIK49894.1 - 0.0006 19.4 0.3 0.0038 16.8 0.1 2.3 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 PIK49894.1 - 0.12 12.4 0.0 0.12 12.4 0.0 3.1 3 1 0 3 3 3 0 Dynamin family RCC1 PF00415.18 PIK49895.1 - 2.4e-58 194.6 21.7 1.2e-11 45.1 0.5 7.6 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK49895.1 - 2.8e-35 119.4 23.5 3.2e-11 42.7 0.3 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Peptidase_S24 PF00717.23 PIK49898.1 - 4.1e-08 33.0 0.0 8.4e-08 32.1 0.0 1.5 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 PIK49898.1 - 2.1e-06 27.6 0.0 0.00038 20.2 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 PX PF00787.24 PIK49899.1 - 2e-13 50.3 0.0 4.2e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 PIK49899.1 - 4.5e-06 26.4 6.8 6.2e-06 25.9 4.8 2.0 2 0 0 2 2 2 1 Vps5 C terminal like rve PF00665.26 PIK49900.1 - 3e-17 62.9 0.0 4.1e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Lactamase_B_2 PF12706.7 PIK49902.1 - 6.4e-36 123.8 0.0 9.8e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK49902.1 - 2.7e-11 43.6 0.0 4.3e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain 3HCDH PF00725.22 PIK49902.1 - 0.023 15.3 0.0 0.097 13.3 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Mito_carr PF00153.27 PIK49903.1 - 4.2e-46 154.8 6.7 6.9e-17 61.2 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Transket_pyr PF02779.24 PIK49904.1 - 1.7e-49 167.9 0.0 3.5e-49 166.9 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 PIK49904.1 - 1.4e-39 134.8 0.1 2.8e-39 133.8 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain RPN5_C PF18098.1 PIK49904.1 - 0.063 13.4 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN5 C-terminal domain Pullulanase_Ins PF18494.1 PIK49904.1 - 0.067 13.7 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Pullulanase Ins domain Ser_hydrolase PF06821.13 PIK49904.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Pkinase PF00069.25 PIK49905.1 - 3.6e-70 236.4 0.0 4.8e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK49905.1 - 9e-28 97.3 0.0 1.4e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK49905.1 - 1.5e-06 27.7 0.2 2.9e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK49905.1 - 0.0014 18.0 0.0 0.0036 16.7 0.0 1.7 1 1 1 2 2 2 1 Kinase-like BEN PF10523.9 PIK49906.1 - 5.4e-05 23.3 0.0 0.00014 22.0 0.0 1.7 1 0 0 1 1 1 1 BEN domain OmpH PF03938.14 PIK49906.1 - 0.13 12.6 4.3 1.8 8.9 1.8 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3552 PF12072.8 PIK49906.1 - 1.5 8.2 6.9 0.28 10.6 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Flavi_glycop_C PF02832.16 PIK49907.1 - 0.0065 16.6 0.0 0.014 15.6 0.0 1.7 1 1 0 1 1 1 1 Flavivirus glycoprotein, immunoglobulin-like domain zf-Di19 PF05605.12 PIK49908.1 - 0.0042 17.4 0.0 0.0098 16.2 0.0 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 PIK49908.1 - 0.011 16.1 1.6 0.014 15.7 1.1 1.5 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 PIK49908.1 - 0.019 15.8 0.4 0.045 14.6 0.4 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK49909.1 - 2e-18 66.6 10.7 4.2e-17 62.3 5.1 2.1 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 PIK49909.1 - 0.0067 17.2 5.8 1.9 9.6 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK49909.1 - 0.016 15.5 0.4 0.016 15.5 0.4 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK49909.1 - 0.033 14.2 0.4 0.033 14.2 0.4 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger COLFI PF01410.18 PIK49909.1 - 0.057 12.7 2.1 0.12 11.6 2.1 1.6 1 1 0 1 1 1 0 Fibrillar collagen C-terminal domain Peptidase_C3G PF12381.8 PIK49909.1 - 0.1 12.1 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase zf-BED PF02892.15 PIK49909.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.0 2 0 0 2 2 2 0 BED zinc finger zf-C2H2 PF00096.26 PIK49909.1 - 0.7 10.5 7.4 1.9 9.1 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Sod_Cu PF00080.20 PIK49910.1 - 1.6e-31 109.4 1.6 1.9e-31 109.1 1.6 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) 7tm_2 PF00002.24 PIK49911.1 - 4.2e-13 49.1 23.5 8.5e-13 48.2 23.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) Colicin_im PF03857.13 PIK49911.1 - 3.4 7.6 12.6 0.12 12.3 4.0 2.4 2 0 0 2 2 2 0 Colicin immunity protein 7tm_2 PF00002.24 PIK49912.1 - 2.9e-22 79.1 15.7 5.2e-22 78.3 15.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK49912.1 - 0.0082 16.5 6.6 0.047 14.1 6.6 2.3 1 0 0 1 1 1 1 Somatomedin B domain GWT1 PF06423.12 PIK49912.1 - 1.4 9.1 7.9 4.7 7.3 3.0 2.6 2 0 0 2 2 2 0 GWT1 BTB PF00651.31 PIK49913.1 - 1.1e-19 70.7 2.4 2e-16 60.2 0.3 2.2 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 PIK49913.1 - 0.00063 19.8 0.9 0.007 16.5 0.2 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.8 PIK49913.1 - 0.04 14.1 0.5 0.23 11.7 0.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Phage_integrase PF00589.22 PIK49915.1 - 0.00059 19.7 0.0 0.0008 19.2 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family RT_RNaseH PF17917.1 PIK49916.1 - 0.012 15.9 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK49916.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SAPIS-gp6 PF16722.5 PIK49917.1 - 0.01 16.2 1.1 0.012 16.0 1.1 1.1 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus LZ_Tnp_IS66 PF13007.7 PIK49917.1 - 0.028 15.2 2.6 0.041 14.7 2.6 1.3 1 1 0 1 1 1 0 Transposase C of IS166 homeodomain EGF_2 PF07974.13 PIK49918.1 - 1.1e-05 25.6 22.4 0.00024 21.4 8.3 4.5 4 1 0 4 4 4 3 EGF-like domain EGF PF00008.27 PIK49918.1 - 0.0014 18.9 18.8 0.0064 16.8 6.7 4.6 4 1 0 4 4 4 2 EGF-like domain hEGF PF12661.7 PIK49918.1 - 0.026 15.1 4.0 0.026 15.1 4.0 5.0 5 0 0 5 5 5 0 Human growth factor-like EGF EGF PF00008.27 PIK49919.1 - 0.0049 17.1 17.8 0.21 11.9 4.3 2.4 2 0 0 2 2 2 2 EGF-like domain DUF3912 PF13051.6 PIK49919.1 - 0.12 12.6 0.0 0.37 11.1 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3912) hEGF PF12661.7 PIK49919.1 - 0.5 11.1 14.2 0.47 11.2 3.0 3.1 2 1 0 2 2 2 0 Human growth factor-like EGF Ldl_recept_a PF00057.18 PIK49920.1 - 1.9e-98 322.4 219.6 4.7e-11 42.7 13.4 12.7 12 0 0 12 12 12 12 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK49920.1 - 2.9e-29 101.3 15.9 1.6e-10 41.3 0.0 8.0 9 0 0 9 9 9 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK49920.1 - 2.8e-08 33.9 8.1 2.8e-08 33.9 8.1 5.3 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 PIK49921.1 - 2.9e-27 94.6 58.8 1.4e-09 38.0 8.0 4.8 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK49922.1 - 4.4e-106 347.1 49.3 5e-11 42.9 0.0 25.0 26 2 0 26 26 26 17 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 PIK49922.1 - 7.4e-63 208.5 165.9 3.5e-10 39.9 16.7 9.7 9 1 1 10 10 10 8 Low-density lipoprotein receptor domain class A SGL PF08450.12 PIK49922.1 - 2.8e-18 66.4 19.4 0.00016 21.4 0.1 8.3 7 2 1 8 8 8 5 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 PIK49922.1 - 5.5e-13 49.0 55.7 1.1e-08 35.2 7.0 10.7 11 1 0 11 11 11 6 Coagulation Factor Xa inhibitory site NHL PF01436.21 PIK49922.1 - 0.0013 18.7 0.3 2.3 8.4 0.0 5.1 4 0 0 4 4 4 1 NHL repeat PAN_4 PF14295.6 PIK49923.1 - 0.0059 16.5 2.9 0.0059 16.5 2.9 3.7 4 1 0 4 4 4 2 PAN domain Activin_recp PF01064.23 PIK49924.1 - 0.14 13.3 3.0 0.54 11.4 3.0 2.1 1 0 0 1 1 1 0 Activin types I and II receptor domain NOG1_N PF17835.1 PIK49924.1 - 5 7.1 14.3 6.6 6.7 0.8 3.7 1 1 3 4 4 4 0 NOG1 N-terminal helical domain Ig_3 PF13927.6 PIK49925.1 - 1.7e-06 28.5 0.0 2.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK49925.1 - 4.7e-06 26.8 0.0 6.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK49925.1 - 6.6e-05 23.0 0.0 9.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK49925.1 - 0.00021 21.5 0.1 0.014 15.6 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK49925.1 - 0.00025 21.1 0.0 0.00034 20.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain DUF2613 PF11021.8 PIK49925.1 - 0.049 13.8 0.4 0.092 12.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) TMEM237 PF15383.6 PIK49927.1 - 4.7e-60 202.8 0.1 4.7e-60 202.8 0.1 1.6 2 0 0 2 2 2 1 Transmembrane protein 237 DUF1772 PF08592.11 PIK49927.1 - 0.016 15.6 0.3 0.032 14.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) VGCC_beta4Aa_N PF12052.8 PIK49927.1 - 0.1 12.7 1.1 0.31 11.2 1.1 1.8 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal EamA PF00892.20 PIK49928.1 - 9.8e-25 87.3 34.1 2.8e-18 66.4 8.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK49928.1 - 0.056 12.8 18.7 0.012 14.9 4.8 2.4 2 1 1 3 3 3 0 Triose-phosphate Transporter family Ank_2 PF12796.7 PIK49929.1 - 7.3e-20 71.3 0.7 2.3e-10 40.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK49929.1 - 2.2e-15 56.3 4.8 2.7e-05 24.4 0.6 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 PIK49929.1 - 3.9e-15 56.0 0.3 4.7e-09 36.6 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK49929.1 - 5.9e-14 52.0 0.2 0.00011 22.4 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK49929.1 - 1.7e-13 49.4 0.4 0.00057 20.1 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat WD40 PF00400.32 PIK49930.1 - 8.7e-51 168.8 17.3 7.8e-09 36.0 0.3 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK49930.1 - 3.1e-12 46.6 0.0 0.01 16.1 0.0 6.2 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK49930.1 - 2.3e-07 29.9 1.2 0.016 13.9 0.0 3.8 2 2 1 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK49930.1 - 9.1e-07 28.9 0.0 0.019 14.9 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK49930.1 - 4.8e-06 25.8 0.0 0.28 10.1 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 PIK49930.1 - 7.9e-06 24.2 0.0 3.8e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 IKI3 family WD40_like PF17005.5 PIK49930.1 - 0.0081 15.5 0.0 5.3 6.3 0.0 3.7 2 1 2 4 4 4 1 WD40-like domain Nbas_N PF15492.6 PIK49930.1 - 0.0082 15.5 1.0 0.59 9.4 0.2 3.0 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Ribosomal_L41 PF05162.13 PIK49931.1 - 0.052 13.6 11.6 0.099 12.7 11.6 1.5 1 0 0 1 1 1 0 Ribosomal protein L41 Ldl_recept_a PF00057.18 PIK49932.1 - 3e-236 763.3 528.5 3e-11 43.3 9.1 32.0 31 1 1 32 32 32 30 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 PIK49932.1 - 7.3e-46 154.4 13.9 1.1e-05 25.8 0.0 12.9 13 0 0 13 13 13 10 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK49932.1 - 1.1e-24 86.4 70.8 9.1e-10 38.7 7.9 18.2 21 3 1 22 22 22 8 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK49932.1 - 2e-12 46.8 9.2 1.1e-08 34.9 1.0 14.5 13 0 0 13 13 13 7 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK49932.1 - 8.8e-11 41.8 55.8 8.3e-07 29.1 6.4 28.7 21 9 12 33 33 33 6 Calcium-binding EGF domain DUF5050 PF16472.5 PIK49932.1 - 1.7e-09 37.3 0.3 0.0003 20.1 0.0 4.1 4 1 1 5 5 5 3 Domain of unknown function (DUF5050) EGF PF00008.27 PIK49932.1 - 0.0051 17.1 6.6 0.0051 17.1 6.6 26.7 30 3 0 31 31 31 6 EGF-like domain Ldl_recept_b PF00058.17 PIK49933.1 - 1.2e-14 54.5 0.2 1e-06 29.1 0.0 5.1 5 0 0 5 5 5 3 Low-density lipoprotein receptor repeat class B cEGF PF12662.7 PIK49933.1 - 2.2e-09 37.0 6.0 8e-06 25.7 0.4 2.9 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK49933.1 - 3.1e-07 30.5 7.6 3.1e-07 30.5 7.6 3.7 2 1 1 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK49933.1 - 6.8e-05 23.1 5.7 6.8e-05 23.1 5.7 2.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 PIK49933.1 - 0.00012 22.3 5.5 0.00012 22.3 5.5 3.2 2 2 1 3 3 3 1 Low-density lipoprotein receptor domain class A EGF PF00008.27 PIK49933.1 - 0.029 14.7 4.9 0.029 14.7 4.9 3.1 2 0 0 2 2 2 0 EGF-like domain DUF5050 PF16472.5 PIK49933.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) SGL PF08450.12 PIK49933.1 - 0.11 12.0 0.2 2.6 7.6 0.0 2.4 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DBR1 PF05011.13 PIK49935.1 - 9.7e-32 110.3 0.0 1.6e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 PIK49935.1 - 7.5e-08 33.1 0.2 1.4e-07 32.3 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MFS_1 PF07690.16 PIK49936.1 - 6.8e-22 77.9 12.9 9.5e-22 77.4 12.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK49936.1 - 1.7e-05 23.6 9.2 2.3e-05 23.1 9.2 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 PIK49936.1 - 0.00044 19.2 6.8 0.0039 16.1 3.0 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 PIK49936.1 - 0.014 13.7 5.4 0.067 11.5 5.0 2.1 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4574 PF15141.6 PIK49938.1 - 0.16 11.9 0.0 0.67 9.9 0.0 2.0 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DUF4064 PF13273.6 PIK49938.1 - 1 9.7 8.5 0.13 12.6 0.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) GKAP PF03359.13 PIK49939.1 - 5.1e-31 108.5 3.3 5.9e-31 108.3 3.3 1.0 1 0 0 1 1 1 1 Guanylate-kinase-associated protein (GKAP) protein DUF4695 PF15766.5 PIK49939.1 - 0.022 15.0 4.2 0.037 14.2 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) NAD_binding_1 PF00175.21 PIK49940.1 - 6.1e-18 65.5 0.0 7.9e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1634 PF07843.11 PIK49941.1 - 0.052 13.6 0.2 0.086 12.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) hGDE_central PF14702.6 PIK49941.1 - 0.11 12.2 0.2 0.13 11.9 0.2 1.0 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme EMI PF07546.13 PIK49942.1 - 1.5e-05 25.7 7.3 1.5e-05 25.7 7.3 1.9 2 0 0 2 2 2 1 EMI domain RIFIN PF02009.16 PIK49942.1 - 0.0051 16.7 1.0 0.0093 15.9 0.0 1.7 1 1 1 2 2 2 1 Rifin EphA2_TM PF14575.6 PIK49942.1 - 0.092 13.6 0.5 0.31 11.9 0.1 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 PIK49942.1 - 0.19 12.7 0.2 0.19 12.7 0.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) TMEM154 PF15102.6 PIK49942.1 - 0.25 11.3 9.6 0.021 14.7 3.7 2.2 1 1 1 2 2 2 0 TMEM154 protein family OAD_gamma PF04277.13 PIK49942.1 - 0.52 10.9 3.5 0.5 11.0 1.3 2.2 1 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Orf78 PF06024.12 PIK49942.1 - 0.56 10.5 0.1 0.56 10.5 0.1 2.5 2 1 1 3 3 3 0 Orf78 (ac78) V-set PF07686.17 PIK49943.1 - 8.2e-08 32.4 0.2 6.6e-07 29.5 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK49943.1 - 1.5e-06 28.3 0.8 8.2e-05 22.7 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK49943.1 - 2.5e-06 28.0 1.7 0.0045 17.6 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK49943.1 - 9.3e-06 25.6 0.2 0.0033 17.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain DUF1533 PF07550.11 PIK49943.1 - 0.2 11.6 0.7 0.46 10.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) V-set PF07686.17 PIK49944.1 - 1.5e-05 25.1 0.3 2e-05 24.7 0.3 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK49944.1 - 0.001 19.6 0.0 0.002 18.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK49944.1 - 0.0011 18.9 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK49944.1 - 0.028 14.6 0.2 0.05 13.8 0.1 1.5 1 1 0 1 1 1 0 Immunoglobulin domain AHD PF17793.1 PIK49944.1 - 0.11 12.3 0.4 0.45 10.3 0.2 1.9 2 0 0 2 2 2 0 ANC1 homology domain (AHD) SLAM PF06214.11 PIK49944.1 - 0.16 12.0 0.2 0.35 10.9 0.1 1.6 2 0 0 2 2 2 0 Signaling lymphocytic activation molecule (SLAM) protein ig PF00047.25 PIK49945.1 - 0.00033 20.8 1.6 0.65 10.2 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK49945.1 - 0.00046 20.2 2.1 0.0018 18.3 0.4 2.6 2 1 2 4 4 4 1 CD80-like C2-set immunoglobulin domain Ribosomal_L28e PF01778.17 PIK49945.1 - 0.094 13.5 0.2 0.3 11.9 0.1 1.8 2 0 0 2 2 2 0 Ribosomal L28e protein family Pkinase_Tyr PF07714.17 PIK49946.1 - 2.9e-07 30.0 0.0 4.3e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49946.1 - 0.0011 18.4 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DNA_pol_phi PF04931.13 PIK49946.1 - 0.019 13.1 42.7 0.023 12.8 42.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pkinase_Tyr PF07714.17 PIK49947.1 - 1.4e-30 106.4 0.0 1.7e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK49947.1 - 2.9e-20 72.8 0.0 4.2e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain BRCT_assoc PF12820.7 PIK49947.1 - 0.026 14.4 0.1 0.056 13.3 0.1 1.5 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT RVT_1 PF00078.27 PIK49948.1 - 1.1e-33 116.6 0.3 1.3e-33 116.4 0.3 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK49949.1 - 1.6e-20 73.0 0.0 3.6e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK49949.1 - 3.3e-19 69.2 0.0 6.1e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK49949.1 - 4.4e-11 42.4 0.0 9.6e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2 PF09337.10 PIK49949.1 - 3.8e-07 30.2 0.0 8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 PIK49949.1 - 1e-05 25.3 3.0 2.4e-05 24.2 3.0 1.7 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK49949.1 - 1.8e-05 24.5 0.0 7.6e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.6 PIK49949.1 - 0.036 14.7 0.0 0.089 13.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease His_Phos_1 PF00300.22 PIK49949.1 - 0.061 13.0 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) RT_RNaseH PF17917.1 PIK49950.1 - 1.9e-37 127.8 0.0 3.4e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK49950.1 - 1.1e-36 124.8 0.0 2.1e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK49950.1 - 2.6e-23 82.7 0.0 4.3e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK49950.1 - 0.018 14.1 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK49950.1 - 0.069 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Cyclin_N PF00134.23 PIK49952.1 - 9.6e-18 64.2 10.9 1.1e-16 60.7 0.1 2.9 3 0 0 3 3 3 2 Cyclin, N-terminal domain TFIIB PF00382.19 PIK49952.1 - 0.19 11.8 0.3 0.62 10.2 0.0 2.0 2 0 0 2 2 2 0 Transcription factor TFIIB repeat zf-C3Hc3H PF13891.6 PIK49953.1 - 1.5e-24 86.1 11.3 2.9e-13 50.0 0.4 2.5 2 0 0 2 2 2 2 Potential DNA-binding domain His_Phos_2 PF00328.22 PIK49955.1 - 1.7e-77 261.3 3.9 4.4e-75 253.4 1.2 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 PIK49955.1 - 1.2e-08 35.0 0.0 3.2e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 PIK49955.1 - 3.2e-05 23.6 0.0 9.3e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Cnd1_N PF12922.7 PIK49955.1 - 0.002 18.0 1.6 0.0048 16.8 1.6 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term DASH_Duo1 PF08651.10 PIK49955.1 - 0.067 13.0 0.4 2.2 8.1 0.0 2.7 2 0 0 2 2 2 0 DASH complex subunit Duo1 Spc29 PF17082.5 PIK49955.1 - 0.071 12.9 7.8 0.96 9.2 1.7 2.4 2 0 0 2 2 2 0 Spindle Pole Component 29 Pyridoxal_deC PF00282.19 PIK49956.1 - 2.7e-85 286.4 0.0 3.2e-85 286.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 PIK49956.1 - 2e-10 40.5 0.0 3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 PIK49956.1 - 0.00012 21.2 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 PIK49956.1 - 0.012 14.4 0.0 0.051 12.3 0.0 1.8 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, major domain SepSecS PF05889.13 PIK49956.1 - 0.013 14.2 0.0 0.021 13.5 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Peptidase_C92 PF05708.12 PIK49956.1 - 0.28 11.3 3.5 4.8 7.2 1.0 2.3 1 1 1 2 2 2 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Ets PF00178.22 PIK49957.1 - 5.7e-37 126.0 0.2 9.1e-37 125.4 0.2 1.3 1 0 0 1 1 1 1 Ets-domain ETS_PEA3_N PF04621.13 PIK49957.1 - 1.4e-35 123.9 14.1 5.1e-35 122.0 10.8 2.6 1 1 1 2 2 2 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Sclerostin PF05463.11 PIK49958.1 - 7.1e-43 146.6 7.9 8.3e-43 146.4 7.9 1.0 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.15 PIK49958.1 - 2.9e-13 49.8 2.4 3.9e-13 49.4 2.4 1.1 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 PIK49958.1 - 3e-06 27.5 2.7 3.8e-06 27.1 2.7 1.2 1 0 0 1 1 1 1 Cystine-knot domain RVT_1 PF00078.27 PIK49959.1 - 2.9e-29 102.2 0.1 7.8e-29 100.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK49959.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Med18 protein LRR_6 PF13516.6 PIK49960.1 - 1.9e-23 80.5 33.8 0.0012 18.8 0.1 11.2 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.7 PIK49960.1 - 3e-13 49.7 21.4 0.025 15.0 0.9 6.8 4 1 4 8 8 8 7 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK49960.1 - 1e-08 34.9 1.8 1e-08 34.9 1.8 2.6 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.33 PIK49960.1 - 2.9e-06 27.1 30.0 6.1 7.8 0.0 10.7 10 1 0 10 10 10 1 Leucine Rich Repeat F-box PF00646.33 PIK49960.1 - 1.3e-05 24.9 0.7 1.3e-05 24.9 0.7 3.2 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.6 PIK49960.1 - 0.001 18.8 8.5 5.6 6.8 0.5 5.7 4 2 1 5 5 5 1 Leucine rich repeat Inhibitor_I29 PF08246.12 PIK49960.1 - 0.13 12.8 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) dUTPase PF00692.19 PIK49961.1 - 3.8e-44 149.5 0.0 4.4e-44 149.3 0.0 1.0 1 0 0 1 1 1 1 dUTPase zf-B_box PF00643.24 PIK49962.1 - 1.9e-14 53.5 18.0 2.2e-10 40.5 4.4 4.2 5 0 0 5 5 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK49962.1 - 2.3e-07 30.7 10.9 2.3e-07 30.7 10.9 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK49962.1 - 7.5e-07 28.9 13.9 7.5e-07 28.9 13.9 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK49962.1 - 8.7e-07 28.7 13.5 8.7e-07 28.7 13.5 3.7 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK49962.1 - 1.4e-06 28.6 12.3 1.4e-06 28.6 12.3 3.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK49962.1 - 8.6e-06 25.6 12.2 8.6e-06 25.6 12.2 3.7 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK49962.1 - 1.8e-05 24.8 14.3 1.8e-05 24.8 14.3 3.7 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK49962.1 - 4e-05 23.4 13.7 4e-05 23.4 13.7 3.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_30C PF17189.4 PIK49962.1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Myb_DNA-bind_5 PF13873.6 PIK49962.1 - 0.13 12.4 2.6 0.28 11.3 2.6 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Mis14 PF08641.12 PIK49962.1 - 0.15 12.4 5.8 0.28 11.5 5.7 1.5 1 1 0 1 1 1 0 Kinetochore protein Mis14 like SMBP PF16785.5 PIK49962.1 - 0.19 11.9 0.3 27 5.0 0.0 2.2 1 1 1 2 2 2 0 Small metal-binding protein BORCS7 PF16088.5 PIK49962.1 - 0.22 11.8 5.6 5.8 7.2 1.8 2.5 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 RICH PF05062.12 PIK49962.1 - 0.85 10.0 5.4 0.68 10.3 2.0 2.3 2 0 0 2 2 2 0 RICH domain OTCace PF00185.24 PIK49962.1 - 1.5 8.9 4.5 11 6.1 2.1 2.3 1 1 1 2 2 2 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain RVT_1 PF00078.27 PIK49963.1 - 2.1e-38 132.1 0.1 2.8e-38 131.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SHR3_chaperone PF08229.11 PIK49964.1 - 0.15 11.0 0.1 0.3 10.0 0.1 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 TPR_MLP1_2 PF07926.12 PIK49965.1 - 0.0052 16.8 4.5 0.0052 16.8 4.5 2.1 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein DUF3475 PF11961.8 PIK49965.1 - 0.2 11.7 2.9 17 5.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) GIT_CC PF16559.5 PIK49965.1 - 0.25 11.2 4.2 1.1 9.1 4.1 2.2 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 PIK49965.1 - 0.71 9.9 4.6 2.6 8.1 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Imm43 PF15570.6 PIK49965.1 - 1.2 9.1 5.0 3.4 7.7 0.3 2.2 1 1 1 2 2 2 0 Immunity protein 43 Exonuc_VII_L PF02601.15 PIK49965.1 - 6 6.3 9.7 9.1 5.7 9.5 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit COesterase PF00135.28 PIK49966.1 - 1.9e-121 406.5 0.6 1.7e-95 320.9 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK49966.1 - 9.6e-09 35.4 0.4 7.3e-08 32.5 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK49966.1 - 0.044 13.2 0.1 0.13 11.7 0.1 1.8 1 0 0 1 1 1 0 Prolyl oligopeptidase family AChE_tetra PF08674.10 PIK49966.1 - 0.6 9.9 6.1 1.8 8.3 6.1 1.8 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK49967.1 - 9.6e-136 453.6 0.0 1.2e-135 453.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK49967.1 - 6.7e-09 35.9 0.4 5.8e-08 32.8 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK49967.1 - 0.02 14.4 0.1 0.057 12.9 0.1 1.8 1 0 0 1 1 1 0 Prolyl oligopeptidase family Phosphodiest PF01663.22 PIK49968.1 - 2.1e-52 178.9 4.4 2.6e-52 178.6 4.4 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK49968.1 - 8.1e-06 25.4 0.6 0.07 12.5 0.0 2.3 2 0 0 2 2 2 2 Sulfatase PglZ PF08665.12 PIK49968.1 - 0.00094 19.3 0.4 0.092 12.8 0.4 2.4 2 0 0 2 2 2 2 PglZ domain COesterase PF00135.28 PIK49969.1 - 3e-102 343.1 0.9 1.4e-59 202.3 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK49969.1 - 0.056 13.3 0.4 0.11 12.4 0.4 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK49969.1 - 0.91 9.3 10.3 0.26 11.0 6.9 1.9 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain Epimerase PF01370.21 PIK49970.1 - 3.9e-26 92.0 0.0 5.3e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK49970.1 - 2.7e-11 43.4 0.2 1e-10 41.5 0.2 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 PIK49970.1 - 2.7e-09 37.2 0.0 4.9e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 PIK49970.1 - 5e-09 35.6 0.1 2.2e-06 26.9 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 PIK49970.1 - 0.0019 17.4 0.2 0.037 13.2 0.2 2.6 1 1 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 PIK49970.1 - 0.0098 16.1 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 PIK49970.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Cpn60_TCP1 PF00118.24 PIK49971.1 - 5.9e-154 513.3 6.3 7.2e-154 513.0 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FAM183 PF14886.6 PIK49972.1 - 0.00036 21.2 1.4 0.00046 20.9 1.4 1.2 1 0 0 1 1 1 1 FAM183A and FAM183B related AI-2E_transport PF01594.16 PIK49973.1 - 0.00018 20.8 16.3 0.0067 15.6 16.3 2.1 1 1 0 1 1 1 1 AI-2E family transporter LapA_dom PF06305.11 PIK49974.1 - 0.019 14.8 0.9 0.019 14.8 0.9 3.8 3 1 1 4 4 4 0 Lipopolysaccharide assembly protein A domain I-set PF07679.16 PIK49976.1 - 2.7e-22 78.6 0.0 4.8e-17 61.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK49976.1 - 5.8e-19 68.5 0.1 6.9e-14 52.2 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK49976.1 - 3.4e-13 49.6 0.0 2.3e-05 24.5 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK49976.1 - 2.6e-12 46.9 0.0 1.5e-07 31.6 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain fn3 PF00041.21 PIK49976.1 - 1.9e-09 37.7 0.2 6.1e-06 26.5 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 PIK49976.1 - 1.4e-07 31.6 0.5 0.012 15.7 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK49976.1 - 1.2e-06 27.9 0.0 0.0096 15.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.5 PIK49976.1 - 0.028 14.7 0.0 7.3 6.9 0.0 2.4 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK49976.1 - 0.038 14.1 0.0 5.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK49976.1 - 0.074 13.6 0.3 1.6 9.4 0.1 3.0 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain Ig_5 PF16681.5 PIK49976.1 - 0.13 12.7 0.0 4.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.15 PIK49976.1 - 0.15 11.8 0.4 12 5.7 0.1 2.8 2 1 0 2 2 2 0 Adenovirus E3 region protein CR1 DUF4555 PF15093.6 PIK49977.1 - 1.6e-51 175.3 6.6 2e-51 174.9 6.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4555) Malt_amylase_C PF16657.5 PIK49980.1 - 0.021 14.9 0.1 0.03 14.4 0.1 1.3 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain AAA_35 PF14516.6 PIK49980.1 - 0.025 13.4 0.1 0.034 13.0 0.1 1.1 1 0 0 1 1 1 0 AAA-like domain DUF3459 PF11941.8 PIK49980.1 - 0.069 13.5 0.1 0.094 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Acetyltransf_10 PF13673.7 PIK49981.1 - 7.8e-13 48.5 0.0 1.8e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK49981.1 - 3.2e-12 46.7 0.0 3.6e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK49981.1 - 2.6e-10 40.6 0.1 4.2e-10 39.9 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK49981.1 - 0.00013 21.9 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 PIK49981.1 - 0.0036 17.4 0.0 0.0066 16.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 PIK49981.1 - 0.015 15.2 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_9 PF13527.7 PIK49981.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nop16 PF09420.10 PIK49981.1 - 0.19 11.8 0.0 0.27 11.2 0.0 1.3 1 1 0 1 1 1 0 Ribosome biogenesis protein Nop16 Arm PF00514.23 PIK49983.1 - 7.4e-12 44.9 1.2 0.00012 22.0 0.0 5.0 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat ubiquitin PF00240.23 PIK49983.1 - 2.2e-06 27.3 0.0 6.7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family DUF3361 PF11841.8 PIK49983.1 - 0.0011 19.0 1.4 0.073 13.0 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) V-ATPase_H_N PF03224.14 PIK49983.1 - 0.012 14.9 1.4 0.052 12.8 0.0 2.2 1 1 0 2 2 2 0 V-ATPase subunit H UNC45-central PF11701.8 PIK49983.1 - 0.059 13.3 0.6 0.42 10.5 0.1 2.4 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central GPP34 PF05719.11 PIK49984.1 - 9.5e-35 120.5 2.9 9.7e-34 117.2 0.4 1.9 1 1 1 2 2 2 2 Golgi phosphoprotein 3 (GPP34) FAST_1 PF06743.15 PIK49986.1 - 1.5e-12 47.2 0.1 5.4e-12 45.5 0.1 2.0 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 PIK49986.1 - 7.2e-10 38.8 3.4 1.6e-09 37.7 1.1 2.6 2 0 0 2 2 2 1 RAP domain VraX PF17412.2 PIK49986.1 - 0.029 14.0 0.6 0.073 12.7 0.6 1.7 1 0 0 1 1 1 0 Family of unknown function FAST_2 PF08368.12 PIK49986.1 - 0.071 13.9 0.1 0.4 11.5 0.0 2.4 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 2 Methyltransf_31 PF13847.6 PIK49987.1 - 5.1e-20 71.8 0.0 1.6e-19 70.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK49987.1 - 8.4e-14 52.1 0.0 1.7e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK49987.1 - 7.7e-11 42.6 0.0 1.6e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK49987.1 - 5.6e-09 36.5 0.0 1.2e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK49987.1 - 4.2e-07 29.9 0.0 7e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK49987.1 - 4.7e-07 29.5 0.0 7.6e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK49987.1 - 5.5e-06 25.9 0.0 1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.7 PIK49987.1 - 0.00094 19.1 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 PIK49987.1 - 0.0039 17.2 0.0 0.006 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK49987.1 - 0.0045 16.4 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 PIK49987.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) CMAS PF02353.20 PIK49987.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.12 PIK49987.1 - 0.019 14.5 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 PIK49987.1 - 0.03 13.6 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GidB PF02527.15 PIK49987.1 - 0.042 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Dimerisation2 PF16864.5 PIK49987.1 - 0.054 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_2 PF00891.18 PIK49987.1 - 0.095 12.0 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain PCMT PF01135.19 PIK49987.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HTH_29 PF13551.6 PIK49987.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix DREV PF05219.12 PIK49987.1 - 0.19 10.8 0.0 0.36 9.9 0.0 1.4 2 0 0 2 2 2 0 DREV methyltransferase HTH_42 PF06224.12 PIK49987.1 - 0.23 10.9 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain tRNA_U5-meth_tr PF05958.11 PIK49987.1 - 0.23 10.4 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase OTU PF02338.19 PIK49988.1 - 3.1e-21 76.2 0.0 9.1e-21 74.7 0.0 1.9 1 0 0 1 1 1 1 OTU-like cysteine protease TAP_C PF03943.13 PIK49988.1 - 1.3e-07 31.2 0.1 2.7e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 TAP C-terminal domain UBA_4 PF14555.6 PIK49988.1 - 0.0013 18.5 0.2 0.0023 17.7 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain UCH_1 PF13423.6 PIK49989.1 - 8.7e-91 304.8 0.1 1.3e-90 304.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 PIK49989.1 - 3.9e-17 63.3 0.0 6.6e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 PIK49989.1 - 0.00016 21.2 0.9 0.15 11.6 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-CCCH_2 PF14608.6 PIK49989.1 - 0.0016 18.8 3.9 0.0042 17.5 3.9 1.8 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger NMDAR2_C PF10565.9 PIK49989.1 - 0.0081 15.1 0.3 0.012 14.5 0.3 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus ANAPC4_WD40 PF12894.7 PIK49989.1 - 0.15 12.4 0.0 19 5.6 0.0 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C15 PF01470.17 PIK49990.1 - 7.9e-18 65.4 0.0 9.7e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Pyroglutamyl peptidase PgaPase_1 PF06162.12 PIK49990.1 - 0.0003 20.6 0.0 0.00039 20.2 0.0 1.1 1 0 0 1 1 1 1 Putative pyroglutamyl peptidase PgaPase_1 Tubulin_3 PF14881.6 PIK49991.1 - 1.3e-30 106.4 0.0 2.3e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 PIK49991.1 - 9.2e-17 61.4 0.0 1.9e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 PIK49991.1 - 1.5e-07 31.8 0.0 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Forkhead PF00250.18 PIK49992.1 - 2.2e-35 120.8 0.0 3.4e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain DZF PF07528.14 PIK49993.1 - 1.4e-78 264.0 0.0 2.4e-78 263.2 0.0 1.4 1 0 0 1 1 1 1 DZF domain Thioredoxin PF00085.20 PIK49994.1 - 7.7e-09 35.5 0.0 0.00015 21.7 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin DIM1 PF02966.16 PIK49994.1 - 0.0009 19.0 0.5 0.037 13.8 0.0 2.3 2 0 0 2 2 2 1 Mitosis protein DIM1 Thioredoxin_6 PF13848.6 PIK49994.1 - 0.00096 19.1 0.1 0.0029 17.5 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 PIK49994.1 - 0.06 13.4 0.0 0.25 11.4 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin domain Imm40 PF15569.6 PIK49994.1 - 0.065 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 40 BCDHK_Adom3 PF10436.9 PIK49996.1 - 8.5e-46 155.8 0.8 1.3e-45 155.2 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 PIK49996.1 - 7.1e-09 36.2 0.0 1.5e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 PIK49996.1 - 0.0002 21.2 0.0 0.00043 20.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase fn3 PF00041.21 PIK49997.1 - 6.6e-73 241.1 10.8 4.5e-16 59.0 0.1 5.9 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 PIK49997.1 - 6.9e-33 112.6 0.0 1.2e-16 60.6 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK49997.1 - 4.9e-30 104.0 0.1 1.1e-12 48.4 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 PIK49997.1 - 4.8e-19 68.5 0.0 5.2e-10 39.5 0.0 3.9 2 1 1 3 3 3 2 Immunoglobulin domain Neogenin_C PF06583.12 PIK49997.1 - 4.4e-17 62.9 4.3 4.4e-17 62.9 4.3 3.5 3 1 0 3 3 3 1 Neogenin C-terminus ig PF00047.25 PIK49997.1 - 8.2e-16 58.0 0.6 4.2e-06 26.8 0.0 4.4 5 0 0 5 5 5 2 Immunoglobulin domain V-set PF07686.17 PIK49997.1 - 1.7e-10 41.0 2.4 0.00046 20.3 0.0 5.5 5 1 1 6 6 6 3 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 PIK49997.1 - 6.9e-09 36.2 10.1 0.11 13.1 1.1 7.0 4 2 0 4 4 4 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK49997.1 - 4.4e-05 23.8 0.8 0.16 12.3 0.0 5.0 6 0 0 6 6 6 1 Uncharacterised conserved protein (DUF2369) Ig_6 PF18452.1 PIK49997.1 - 0.0012 18.3 0.0 0.54 9.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain 7tm_2 PF00002.24 PIK49998.1 - 9.7e-28 97.1 4.7 1.1e-27 96.9 4.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK49998.1 - 0.058 13.7 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Hormone receptor domain 7tm_2 PF00002.24 PIK49999.1 - 8.8e-22 77.6 23.4 5.8e-21 74.9 22.8 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) CENP-B_dimeris PF09026.10 PIK49999.1 - 0.00029 21.2 8.7 0.0006 20.2 8.7 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain GCIP PF13324.6 PIK49999.1 - 0.019 14.6 4.8 0.034 13.7 4.8 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 PIK49999.1 - 0.036 12.6 6.2 0.048 12.2 6.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 PIK49999.1 - 0.054 11.8 0.1 0.079 11.2 0.1 1.3 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 PIK49999.1 - 0.074 13.4 10.3 0.16 12.4 10.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 PIK49999.1 - 0.075 13.1 2.5 0.13 12.3 2.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 PIK49999.1 - 0.14 11.9 1.2 0.24 11.1 1.2 1.5 1 0 0 1 1 1 0 FAM176 family DUF3377 PF11857.8 PIK49999.1 - 0.38 10.7 3.0 1.1 9.2 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3377) Utp14 PF04615.13 PIK49999.1 - 0.95 8.0 4.2 1.2 7.7 4.2 1.0 1 0 0 1 1 1 0 Utp14 protein Bd3614-deam PF14439.6 PIK49999.1 - 1.7 8.7 4.5 2.9 7.9 4.5 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase Nop14 PF04147.12 PIK49999.1 - 1.9 6.6 5.2 2.7 6.1 5.2 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 PIK49999.1 - 2.6 6.0 15.0 0.42 8.7 11.5 1.4 2 0 0 2 2 2 0 DNA polymerase phi DUF2457 PF10446.9 PIK49999.1 - 8.7 5.4 21.2 13 4.8 21.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Fibrinogen_C PF00147.18 PIK50000.1 - 5.5e-27 95.0 0.5 6.3e-27 94.8 0.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain tRNA-synt_2 PF00152.20 PIK50001.1 - 3.7e-68 229.9 0.0 5e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 PIK50001.1 - 2.7e-15 56.1 0.1 4.4e-14 52.2 0.0 2.6 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 PIK50001.1 - 0.0021 17.6 0.0 0.005 16.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) DDRGK PF09756.9 PIK50001.1 - 2.3 7.8 13.5 4.1 6.9 13.5 1.3 1 0 0 1 1 1 0 DDRGK domain APG9 PF04109.16 PIK50002.1 - 2.6e-149 498.3 16.5 9.6e-101 338.2 4.2 2.1 1 1 1 2 2 2 2 Autophagy protein Apg9 Sulfotransfer_2 PF03567.14 PIK50003.1 - 2.3e-10 40.8 0.1 2.7e-10 40.6 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK50003.1 - 0.034 14.5 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family Ion_trans PF00520.31 PIK50004.1 - 8.3e-25 87.4 23.2 1.2e-24 86.9 23.2 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK50004.1 - 8.8e-18 64.2 0.0 1.8e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK50004.1 - 0.012 15.6 0.8 0.012 15.6 0.8 2.6 3 0 0 3 3 3 0 Ion channel Apolipoprotein PF01442.18 PIK50005.1 - 0.0017 18.2 27.0 0.0017 18.2 27.0 4.0 1 1 3 4 4 4 2 Apolipoprotein A1/A4/E domain End3 PF12761.7 PIK50005.1 - 0.018 15.2 6.5 0.018 15.2 6.5 4.8 2 1 4 6 6 6 0 Actin cytoskeleton-regulatory complex protein END3 DUF948 PF06103.11 PIK50005.1 - 0.02 15.2 0.5 0.02 15.2 0.5 5.3 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) gpW PF02831.15 PIK50005.1 - 0.1 12.5 1.8 0.25 11.3 0.4 2.6 2 0 0 2 2 2 0 gpW Filament PF00038.21 PIK50005.1 - 0.41 10.2 80.1 2.3 7.7 25.4 4.5 1 1 2 3 3 3 0 Intermediate filament protein DUF4407 PF14362.6 PIK50005.1 - 3.2 7.0 61.3 0.32 10.3 0.2 4.6 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) DAO_C PF16901.5 PIK50005.1 - 6.5 6.6 9.3 1 9.2 1.8 3.2 2 2 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase DUF4407 PF14362.6 PIK50006.1 - 0.00033 20.1 7.9 0.00041 19.8 7.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Dict-STAT-coil PF09267.10 PIK50006.1 - 0.017 15.5 9.3 0.2 12.0 1.1 2.1 2 0 0 2 2 2 0 Dictyostelium STAT, coiled coil DUF4570 PF15134.6 PIK50006.1 - 0.041 13.9 2.1 0.041 13.9 2.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4570) HALZ PF02183.18 PIK50006.1 - 0.44 10.8 10.5 3.6 7.9 0.9 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper Vfa1 PF08432.10 PIK50006.1 - 8.4 6.7 10.6 15 5.9 10.6 1.4 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Asp-B-Hydro_N PF05279.11 PIK50007.1 - 0.0042 17.2 9.3 0.005 17.0 9.3 1.1 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region PBECR5 PF18814.1 PIK50007.1 - 0.033 14.2 8.5 0.041 13.8 8.5 1.1 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 SpecificRecomb PF10136.9 PIK50007.1 - 0.25 9.6 6.4 0.32 9.3 6.4 1.0 1 0 0 1 1 1 0 Site-specific recombinase Tox-ODYAM1 PF15642.6 PIK50007.1 - 0.39 9.6 8.7 0.54 9.2 8.7 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus UPF0242 PF06785.11 PIK50007.1 - 0.55 10.3 18.5 0.86 9.7 18.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMCO5 PF14992.6 PIK50007.1 - 0.87 9.1 23.3 1.6 8.3 23.3 1.3 1 0 0 1 1 1 0 TMCO5 family Presenilin PF01080.17 PIK50007.1 - 1.4 7.6 6.3 1.8 7.2 6.3 1.2 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 PIK50007.1 - 1.5 7.5 5.7 1.9 7.2 5.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LemA PF04011.12 PIK50007.1 - 2.2 8.1 11.6 10 5.9 11.6 1.9 1 1 0 1 1 1 0 LemA family LMBR1 PF04791.16 PIK50007.1 - 3.1 6.6 4.3 3.8 6.3 4.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FapA PF03961.13 PIK50007.1 - 3.7 6.1 11.6 6 5.4 11.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF745 PF05335.13 PIK50007.1 - 5.8 6.6 15.5 3.8 7.2 13.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Hid1 PF12722.7 PIK50007.1 - 8.3 4.4 11.8 11 4.0 11.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DAP PF15228.6 PIK50007.1 - 9 7.5 7.7 5.1 8.3 5.4 1.7 1 1 1 2 2 2 0 Death-associated protein VBS PF08913.10 PIK50008.1 - 0.17 12.3 2.1 0.31 11.5 0.3 2.4 2 0 0 2 2 2 0 Vinculin Binding Site Baculo_PEP_C PF04513.12 PIK50008.1 - 1.1 9.3 15.5 2.4 8.2 0.3 4.4 3 2 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DFP PF04127.15 PIK50008.1 - 3.2 7.6 8.3 0.24 11.2 2.4 2.1 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein PACT_coil_coil PF10495.9 PIK50009.1 - 5.1e-24 84.7 0.3 5.1e-24 84.7 0.3 7.6 7 1 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein SNARE PF05739.19 PIK50009.1 - 3.1 7.8 5.7 9.5 6.3 0.1 4.0 3 0 0 3 3 3 0 SNARE domain Fibrinogen_C PF00147.18 PIK50010.1 - 1.2e-50 172.4 1.9 1.9e-50 171.7 1.9 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF1619 PF07773.11 PIK50010.1 - 0.43 10.4 5.1 0.76 9.6 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1619) Exo_endo_phos_2 PF14529.6 PIK50011.1 - 0.0043 16.9 0.0 0.0078 16.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK50011.1 - 0.023 14.2 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Nod_GRP PF07806.11 PIK50011.1 - 1.6 8.6 6.8 4.3 7.2 6.8 1.7 1 0 0 1 1 1 0 Nodule-specific GRP repeat RVT_1 PF00078.27 PIK50012.1 - 7.8e-47 159.6 0.2 1e-46 159.2 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_2b PF00587.25 PIK50013.1 - 3.1e-10 40.3 0.1 8.7e-10 38.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF3046 PF11248.8 PIK50013.1 - 0.17 12.3 0.0 0.47 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3046) HGTP_anticodon PF03129.20 PIK50014.1 - 2.6e-22 78.7 0.0 6.7e-22 77.4 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain CDC4_D PF16856.5 PIK50015.1 - 3.1 7.7 13.1 27 4.7 0.7 4.6 2 1 3 5 5 5 0 Cell division control protein 4 dimerisation domain PAZ PF02170.22 PIK50017.1 - 0.013 15.3 0.4 0.027 14.3 0.4 1.5 1 0 0 1 1 1 0 PAZ domain Xan_ur_permease PF00860.20 PIK50018.1 - 5.5e-42 143.8 10.5 7.2e-42 143.5 10.5 1.2 1 0 0 1 1 1 1 Permease family AAA PF00004.29 PIK50019.1 - 3.4e-12 46.9 0.0 1.3e-11 45.0 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 PIK50019.1 - 2.2e-06 27.5 0.0 5.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 PIK50019.1 - 9e-05 23.0 1.0 0.027 15.0 0.0 3.7 2 2 0 2 2 2 1 ABC transporter IstB_IS21 PF01695.17 PIK50019.1 - 0.00012 21.9 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 PIK50019.1 - 0.00018 21.8 0.1 0.019 15.2 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 PIK50019.1 - 0.00018 21.5 0.0 0.0013 18.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 PIK50019.1 - 0.00026 21.0 0.0 0.0028 17.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 PIK50019.1 - 0.00069 19.8 0.0 0.0043 17.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK50019.1 - 0.0028 18.1 0.1 0.022 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 PIK50019.1 - 0.005 16.8 0.0 0.048 13.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 PIK50019.1 - 0.0051 17.4 0.0 0.042 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK50019.1 - 0.012 15.3 0.0 0.15 11.7 0.0 2.5 3 0 0 3 3 2 0 AAA domain Poly_export PF02563.16 PIK50019.1 - 0.019 15.2 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 Polysaccharide biosynthesis/export protein AAA_24 PF13479.6 PIK50019.1 - 0.019 14.7 0.0 0.055 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK50019.1 - 0.048 13.2 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK50019.1 - 0.065 13.1 0.0 0.93 9.4 0.0 2.5 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 PIK50019.1 - 0.09 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 PIK50019.1 - 0.12 12.7 0.0 1 9.8 0.0 2.6 3 0 0 3 3 2 0 RNA helicase AAA_19 PF13245.6 PIK50019.1 - 0.14 12.4 3.1 1.5 9.2 0.1 3.5 3 2 1 4 4 4 0 AAA domain TsaE PF02367.17 PIK50019.1 - 0.15 12.1 0.0 0.61 10.1 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Proteasom_Rpn13 PF04683.13 PIK50020.1 - 1.6e-32 111.9 0.1 2.9e-32 111.0 0.1 1.5 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 PIK50020.1 - 2.1e-27 95.5 2.8 4.4e-27 94.5 2.8 1.5 1 0 0 1 1 1 1 UCH-binding domain GCP_C_terminal PF04130.13 PIK50021.1 - 1.8e-38 132.7 7.8 3e-38 132.0 7.8 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 PIK50021.1 - 7.9e-13 48.7 0.1 2.6e-12 47.0 0.0 1.9 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_N_terminal PF17681.1 PIK50022.1 - 1.6e-08 34.6 0.1 2.3e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Ribosomal_S8e PF01201.22 PIK50023.1 - 8.3e-55 184.7 1.2 1.1e-54 184.3 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Ribosomal_L16 PF00252.18 PIK50023.1 - 0.02 14.9 0.7 0.053 13.5 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L16p/L10e Lipid_DES PF08557.10 PIK50023.1 - 5.9 6.5 7.5 0.18 11.3 1.1 1.8 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) Sushi PF00084.20 PIK50024.1 - 5.4e-08 33.3 17.2 0.0062 17.1 2.4 3.3 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK50025.1 - 6.8e-07 29.8 24.7 0.0022 18.5 2.1 4.8 3 1 1 4 4 4 3 Sushi repeat (SCR repeat) PAN_1 PF00024.26 PIK50025.1 - 6.4e-05 22.9 1.9 6.4e-05 22.9 1.9 4.2 6 0 0 6 6 6 2 PAN domain Hamartin PF04388.12 PIK50026.1 - 0.0063 15.2 6.5 0.0075 15.0 6.5 1.1 1 0 0 1 1 1 1 Hamartin protein CBM_25 PF03423.13 PIK50026.1 - 0.028 14.7 0.6 0.066 13.5 0.6 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) DUF3540 PF12059.8 PIK50026.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) MFS_1 PF07690.16 PIK50027.1 - 1.8e-05 23.8 28.2 4.5e-05 22.5 28.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3925 PF13063.6 PIK50027.1 - 0.032 14.5 0.6 0.086 13.1 0.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3925) DUF2304 PF10066.9 PIK50027.1 - 0.97 9.7 10.3 2.7 8.3 1.3 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF2273 PF10031.9 PIK50027.1 - 2.4 8.2 17.4 1.7 8.7 0.7 4.3 4 1 0 4 4 4 0 Small integral membrane protein (DUF2273) MFS_1 PF07690.16 PIK50028.1 - 1.4e-09 37.4 6.6 2e-09 36.9 6.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 PIK50028.1 - 0.051 13.1 0.1 0.062 12.8 0.1 1.2 1 0 0 1 1 1 0 Nodulin-like Sulfatase PF00884.23 PIK50029.1 - 2.5e-18 66.5 0.1 2.9e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK50029.1 - 0.016 14.8 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK50030.1 - 4.8e-24 85.3 0.0 8.2e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 PIK50030.1 - 0.0038 15.9 0.0 0.0065 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 PIK50030.1 - 0.12 11.9 0.1 0.45 10.0 0.0 1.9 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase PWI PF01480.17 PIK50031.1 - 5.6e-06 26.6 0.1 0.0013 19.0 0.1 2.3 1 1 1 2 2 2 2 PWI domain DUF1539 PF07560.11 PIK50031.1 - 0.0091 16.1 1.9 0.38 10.8 1.0 2.2 1 1 1 2 2 2 2 Domain of Unknown Function (DUF1539) TetR_C_16 PF17920.1 PIK50031.1 - 0.082 13.2 0.1 0.18 12.0 0.1 1.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Musclin PF11037.8 PIK50031.1 - 1.7 8.6 4.3 4.5 7.2 0.1 2.2 1 1 1 2 2 2 0 Insulin-resistance promoting peptide in skeletal muscle CENP-O PF09496.10 PIK50032.1 - 8e-07 29.2 0.0 8e-07 29.2 0.0 2.4 1 1 1 2 2 2 1 Cenp-O kinetochore centromere component PHB_acc PF05233.13 PIK50032.1 - 0.068 13.2 0.1 0.22 11.6 0.1 1.9 1 1 0 1 1 1 0 PHB accumulation regulatory domain DUF2570 PF10828.8 PIK50032.1 - 6.8 6.5 10.0 7.1 6.5 7.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) PTH2 PF01981.16 PIK50033.1 - 5.7e-22 78.2 0.2 6.9e-22 77.9 0.2 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 HSP33 PF01430.19 PIK50033.1 - 0.062 12.7 0.0 0.065 12.7 0.0 1.0 1 0 0 1 1 1 0 Hsp33 protein PTPLA PF04387.14 PIK50034.1 - 2.5e-13 50.1 0.7 2.5e-13 50.1 0.7 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA AA_permease PF00324.21 PIK50036.1 - 1.3e-40 139.4 13.7 2.1e-40 138.7 13.7 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 PIK50036.1 - 8.4e-24 84.2 12.6 8.4e-24 84.2 12.6 1.3 2 0 0 2 2 2 1 Amino acid permease Isochorismatase PF00857.20 PIK50037.1 - 2.5e-16 60.4 0.1 3.5e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.20 PIK50038.1 - 3.8e-06 27.2 0.0 8.5e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Isochorismatase family zf-H2C2_5 PF13909.6 PIK50039.1 - 0.072 12.9 8.0 2.8 7.8 3.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain ThiF PF00899.21 PIK50040.1 - 4.4e-38 131.0 0.0 7.3e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 PIK50040.1 - 7.4e-20 71.3 1.2 2.1e-19 69.9 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 PIK50040.1 - 3.9e-07 30.2 8.1 0.00018 21.5 0.0 3.2 3 1 0 3 3 3 2 Ubiquitin-activating enzyme active site UBA2_C PF16195.5 PIK50040.1 - 0.00018 22.1 10.0 0.0004 21.0 10.0 1.6 1 0 0 1 1 1 1 SUMO-activating enzyme subunit 2 C-terminus zf-C2HE PF16278.5 PIK50040.1 - 0.17 12.3 2.0 0.26 11.8 0.0 2.4 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4279 PF14106.6 PIK50041.1 - 0.067 13.4 0.1 0.74 10.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) HAUS4 PF14735.6 PIK50042.1 - 9.8e-62 208.7 7.6 9.8e-62 208.7 7.6 2.2 2 1 0 2 2 2 1 HAUS augmin-like complex subunit 4 HBM PF16591.5 PIK50042.1 - 0.0071 15.8 0.5 0.0071 15.8 0.5 1.9 3 0 0 3 3 3 1 Helical bimodular sensor domain Syntaxin-18_N PF10496.9 PIK50042.1 - 0.048 13.9 0.2 0.2 11.9 0.2 2.1 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Phosphodiest PF01663.22 PIK50043.1 - 2.9e-07 30.4 0.1 3.7e-07 30.1 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Phosphodiest PF01663.22 PIK50044.1 - 6.7e-60 203.6 1.1 8e-60 203.3 1.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK50044.1 - 9.7e-08 31.7 0.1 0.0034 16.8 0.0 2.1 2 0 0 2 2 2 2 Sulfatase PglZ PF08665.12 PIK50044.1 - 0.017 15.2 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 PglZ domain Rad1 PF02144.16 PIK50044.1 - 0.033 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Repair protein Rad1/Rec1/Rad17 DUF3689 PF12463.8 PIK50045.1 - 2.9e-86 289.6 11.2 5.1e-86 288.8 11.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) YtpI PF14007.6 PIK50046.1 - 2.4 8.4 5.5 0.33 11.1 0.4 2.3 2 0 0 2 2 2 0 YtpI-like protein HEAT_EZ PF13513.6 PIK50047.1 - 1.2e-07 32.1 1.8 7.7e-07 29.5 0.2 3.3 3 0 0 3 3 3 1 HEAT-like repeat Arm PF00514.23 PIK50047.1 - 4.9e-05 23.2 4.1 0.00029 20.8 0.1 4.3 4 1 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK50047.1 - 0.017 15.5 0.5 4.4 7.8 0.0 3.6 3 1 0 3 3 3 0 HEAT repeats HEAT PF02985.22 PIK50047.1 - 0.067 13.5 0.1 0.067 13.5 0.1 3.6 4 0 0 4 4 4 0 HEAT repeat Atx10homo_assoc PF09759.9 PIK50047.1 - 0.09 12.8 3.7 0.46 10.5 2.1 3.0 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain EnY2 PF10163.9 PIK50048.1 - 6.1e-34 116.2 0.4 7.2e-34 116.0 0.4 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF2294 PF10057.9 PIK50048.1 - 0.028 14.6 0.3 0.12 12.5 0.1 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2294) DUF629 PF04780.12 PIK50049.1 - 0.0088 14.6 0.6 0.011 14.3 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF629) ARS2 PF04959.13 PIK50049.1 - 0.0098 16.3 0.2 0.016 15.6 0.2 1.3 1 0 0 1 1 1 1 Arsenite-resistance protein 2 Actin_micro PF17003.5 PIK50049.1 - 0.013 14.7 0.1 0.013 14.7 0.1 1.1 1 0 0 1 1 1 0 Putative actin-like family zf-C2H2_4 PF13894.6 PIK50049.1 - 0.21 12.5 0.4 0.21 12.5 0.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK50049.1 - 0.22 12.1 0.3 0.22 12.1 0.3 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type Glyco_hydro_1 PF00232.18 PIK50050.1 - 7.8e-162 538.8 0.1 9e-162 538.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 PIK50050.1 - 0.00041 19.9 0.0 0.032 13.7 0.0 2.3 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Lipase_GDSL_2 PF13472.6 PIK50050.1 - 0.027 14.8 0.0 0.098 13.0 0.0 1.9 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Pep_deformylase PF01327.21 PIK50052.1 - 1.4e-42 145.0 0.0 1.9e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase Tricorn_C1 PF14684.6 PIK50052.1 - 0.019 15.0 0.2 0.052 13.6 0.2 1.7 1 0 0 1 1 1 0 Tricorn protease C1 domain CobA_CobO_BtuR PF02572.15 PIK50052.1 - 0.085 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF4708 PF15813.5 PIK50053.1 - 3.5e-90 301.9 1.1 6.1e-90 301.1 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4708) HeH PF12949.7 PIK50053.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 HeH/LEM domain HYR PF02494.16 PIK50054.1 - 0 1299.8 146.9 5.1e-26 90.8 1.3 20.3 19 1 1 20 20 20 20 HYR domain EGF PF00008.27 PIK50054.1 - 3.2e-29 100.9 194.0 4.5e-06 26.9 0.4 13.2 12 2 0 12 12 12 11 EGF-like domain hEGF PF12661.7 PIK50054.1 - 5.3e-10 39.5 153.3 0.0067 17.0 0.5 13.6 12 1 0 12 12 12 10 Human growth factor-like EGF DUF5011 PF16403.5 PIK50054.1 - 0.00089 19.3 14.8 29 4.9 0.0 10.9 14 0 0 14 14 14 1 Domain of unknown function (DUF5011) PA_decarbox PF05870.11 PIK50054.1 - 0.69 9.5 23.5 21 4.7 0.0 9.9 14 0 0 14 14 14 0 Phenolic acid decarboxylase (PAD) AA_permease_2 PF13520.6 PIK50055.1 - 9.9e-16 57.6 7.6 1e-10 41.1 4.3 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 PIK50055.1 - 8.8e-12 44.3 3.0 2.3e-11 43.0 3.0 1.5 1 1 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 PIK50055.1 - 0.0069 15.1 0.9 0.011 14.5 0.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TrbC PF04956.13 PIK50055.1 - 0.017 15.3 0.7 0.017 15.3 0.7 1.9 2 0 0 2 2 2 0 TrbC/VIRB2 family SirB PF04247.12 PIK50055.1 - 0.078 13.1 1.7 0.091 12.8 0.2 1.8 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB AA_permease_2 PF13520.6 PIK50056.1 - 3.8e-14 52.4 14.4 4.4e-14 52.2 14.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK50056.1 - 2.3e-06 26.5 14.0 2.5e-06 26.4 14.0 1.0 1 0 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 PIK50056.1 - 3.6 7.3 6.3 0.53 9.9 0.8 2.0 2 0 0 2 2 2 0 Intrinsic membrane protein PufX Glyco_transf_7N PF13733.6 PIK50057.1 - 0.00022 20.9 0.0 0.00023 20.8 0.0 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Exo_endo_phos_2 PF14529.6 PIK50058.1 - 6.4e-06 26.0 0.1 1.3e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK50058.1 - 0.14 11.7 0.2 0.59 9.6 0.1 2.0 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family Ldl_recept_a PF00057.18 PIK50059.1 - 2.9e-05 24.2 7.6 2.9e-05 24.2 7.6 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK50059.1 - 0.00011 22.5 1.3 0.00095 19.5 0.1 2.7 3 0 0 3 3 3 1 CUB domain ASL_C PF08328.11 PIK50059.1 - 0.034 14.2 0.1 0.079 13.1 0.1 1.6 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal MID_MedPIWI PF18296.1 PIK50059.1 - 0.043 13.6 2.2 0.064 13.0 2.2 1.3 1 0 0 1 1 1 0 MID domain of medPIWI Shisa PF13908.6 PIK50059.1 - 0.12 12.6 3.4 0.11 12.7 0.4 2.5 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator Patched PF02460.18 PIK50060.1 - 9.6e-18 63.7 4.2 9.6e-18 63.7 4.2 1.5 2 0 0 2 2 2 1 Patched family SecE PF00584.20 PIK50060.1 - 0.018 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DUF4926 PF16277.5 PIK50060.1 - 0.12 11.7 0.9 3.7 7.0 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4926) Sterol-sensing PF12349.8 PIK50061.1 - 2.4e-53 180.1 2.8 2.4e-53 180.1 2.8 2.9 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 PIK50061.1 - 3.5e-42 144.5 8.9 1.9e-40 138.7 3.5 2.8 3 0 0 3 3 3 2 Patched family MMPL PF03176.15 PIK50061.1 - 7.6e-07 28.4 5.4 7.6e-07 28.4 5.4 2.4 2 0 0 2 2 2 1 MMPL family Sulfotransfer_3 PF13469.6 PIK50062.1 - 4.8e-06 27.1 0.0 1.2e-05 25.8 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family rve PF00665.26 PIK50063.1 - 3.1e-17 62.8 0.0 1.6e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK50063.1 - 2.1e-13 50.2 0.3 4.4e-13 49.1 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain SOCS_box PF07525.16 PIK50063.1 - 0.02 15.2 0.6 9.5 6.7 0.0 2.7 2 0 0 2 2 2 0 SOCS box RVT_1 PF00078.27 PIK50064.1 - 5.8e-28 97.9 0.0 1e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BLOC1_2 PF10046.9 PIK50065.1 - 0.082 13.2 1.5 8.2 6.8 0.4 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zinc_ribbon_2 PF13240.6 PIK50065.1 - 3.1 7.6 9.4 5.4 6.9 9.4 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_5 PF14787.6 PIK50065.1 - 9.7 6.0 16.7 0.11 12.3 7.1 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF4551 PF15087.6 PIK50066.1 - 0.0013 17.6 0.4 0.0016 17.4 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) eIF-3c_N PF05470.12 PIK50066.1 - 0.34 9.2 19.5 0.41 8.9 19.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CCSAP PF15748.5 PIK50066.1 - 1.4 9.0 17.9 1.8 8.7 17.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TP53IP5 PF15331.6 PIK50066.1 - 5 7.2 9.6 6.6 6.8 9.6 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 LAP1C PF05609.12 PIK50066.1 - 6.2 5.8 13.1 7.5 5.5 13.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 PIK50066.1 - 8.2 4.6 26.8 11 4.2 26.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Tetraspanin PF00335.20 PIK50067.1 - 0.027 14.2 9.8 0.084 12.6 9.8 1.7 1 1 0 1 1 1 0 Tetraspanin family CD20 PF04103.15 PIK50067.1 - 0.034 14.2 16.3 0.14 12.3 16.3 2.0 1 1 0 1 1 1 0 CD20-like family RVT_1 PF00078.27 PIK50068.1 - 3.1e-18 66.1 0.0 3.8e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK50070.1 - 2.1e-29 102.6 0.0 2.6e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CotJB PF12652.7 PIK50070.1 - 0.051 13.8 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 CotJB protein YlmH_RBD PF17774.1 PIK50070.1 - 0.16 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH zf-CCHC PF00098.23 PIK50071.1 - 5.1e-05 23.1 15.2 0.0033 17.4 3.3 3.2 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK50071.1 - 0.00011 21.9 14.3 0.29 10.9 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK50071.1 - 0.003 17.4 0.2 0.003 17.4 0.2 2.8 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK50071.1 - 2.2 8.6 12.1 0.75 10.1 6.7 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RT_RNaseH_2 PF17919.1 PIK50077.1 - 1.2e-32 111.9 0.1 2.5e-32 110.9 0.0 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50077.1 - 3.3e-28 98.0 0.0 6.1e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50078.1 - 2e-09 37.3 0.1 3.5e-09 36.5 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIG1 PF04548.16 PIK50079.1 - 4.1e-19 68.8 0.7 4.7e-19 68.6 0.1 1.4 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 PIK50079.1 - 8.9e-08 32.2 0.1 2.8e-07 30.6 0.0 1.8 2 1 1 3 3 3 1 50S ribosome-binding GTPase IIGP PF05049.13 PIK50079.1 - 8.1e-06 25.1 0.0 1e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 PIK50079.1 - 0.00045 20.2 0.0 0.00065 19.6 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 PIK50079.1 - 0.0014 18.7 5.4 0.57 10.2 0.2 2.9 1 1 2 3 3 3 2 Dynamin family ABC_tran PF00005.27 PIK50079.1 - 0.0017 18.9 0.5 0.0034 17.9 0.1 1.7 1 1 1 2 2 2 1 ABC transporter RNA_helicase PF00910.22 PIK50079.1 - 0.0018 18.6 0.1 0.0036 17.7 0.0 1.5 2 0 0 2 2 1 1 RNA helicase Guanylate_kin PF00625.21 PIK50079.1 - 0.024 14.3 0.3 0.073 12.8 0.0 1.9 2 0 0 2 2 2 0 Guanylate kinase FtsK_SpoIIIE PF01580.18 PIK50079.1 - 0.033 13.6 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_10 PF12846.7 PIK50079.1 - 0.033 13.1 0.1 0.068 12.1 0.1 1.5 1 1 0 1 1 1 0 AAA-like domain AAA_7 PF12775.7 PIK50079.1 - 0.034 13.7 0.1 0.095 12.2 0.0 1.7 1 1 1 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 PIK50079.1 - 0.045 13.3 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Sigma54_activat PF00158.26 PIK50079.1 - 0.087 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 PIK50079.1 - 0.09 11.8 0.7 0.34 9.9 0.3 1.7 1 1 1 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 PIK50079.1 - 0.097 11.6 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 PIK50079.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 PIK50079.1 - 0.51 10.4 5.3 0.2 11.7 0.7 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain AIG1 PF04548.16 PIK50080.1 - 1.2e-08 34.6 0.7 3.4e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 AIG1 family FAM178 PF14816.6 PIK50080.1 - 0.027 13.4 0.9 0.038 13.0 0.9 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF1525 PF07511.11 PIK50080.1 - 0.37 10.9 4.5 0.2 11.8 1.4 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1525) FMN_bind_2 PF04299.12 PIK50080.1 - 0.78 9.4 3.4 0.77 9.4 1.8 1.8 1 1 1 2 2 2 0 Putative FMN-binding domain RVT_1 PF00078.27 PIK50082.1 - 2.7e-25 89.2 0.0 5.2e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK50082.1 - 2.7e-11 43.7 0.0 5.6e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50082.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK50084.1 - 0.00032 20.3 0.0 0.00056 19.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_1_7 PF13843.6 PIK50085.1 - 2.2e-67 227.9 0.1 2.5e-67 227.6 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.21 PIK50085.1 - 0.06 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain GUB_WAK_bind PF13947.6 PIK50086.1 - 1.6e-10 41.6 1.7 1.8 9.4 0.0 5.0 1 1 4 5 5 5 4 Wall-associated receptor kinase galacturonan-binding IL15 PF02372.15 PIK50086.1 - 0.00023 21.2 4.6 31 4.6 0.1 6.3 1 1 7 8 8 8 0 Interleukin 15 DUF3786 PF12654.7 PIK50086.1 - 0.0006 19.4 0.1 52 3.4 0.0 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3786) Cyanate_lyase PF02560.14 PIK50086.1 - 0.018 14.9 6.6 1e+02 2.9 0.1 5.1 5 0 0 5 5 5 0 Cyanate lyase C-terminal domain APC_rep PF18797.1 PIK50086.1 - 0.019 15.9 0.7 2.7e+02 2.6 0.0 4.3 5 0 0 5 5 5 0 Adenomatous polyposis coli (APC) repeat CAP18_C PF12153.8 PIK50086.1 - 0.041 13.8 14.9 42 4.1 0.1 5.6 5 0 0 5 5 5 0 LPS binding domain of CAP18 (C terminal) EssA PF10661.9 PIK50086.1 - 0.55 10.1 14.2 36 4.2 0.2 5.2 1 1 4 5 5 5 0 WXG100 protein secretion system (Wss), protein EssA Transpos_assoc PF13963.6 PIK50086.1 - 0.72 10.2 8.7 1.1e+02 3.3 0.0 4.5 5 0 0 5 5 5 0 Transposase-associated domain GUB_WAK_bind PF13947.6 PIK50087.1 - 1.8e-08 35.0 0.3 0.39 11.5 0.0 3.1 1 1 2 3 3 3 3 Wall-associated receptor kinase galacturonan-binding DUF2517 PF10725.9 PIK50087.1 - 0.00011 21.9 0.5 9.8 6.0 0.0 3.4 3 0 0 3 3 3 3 Protein of unknown function (DUF2517) IL15 PF02372.15 PIK50087.1 - 0.00024 21.1 0.6 17 5.5 0.1 4.4 1 1 2 3 3 3 0 Interleukin 15 DUF3786 PF12654.7 PIK50087.1 - 0.0053 16.4 0.0 30 4.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3786) Recombinase PF07508.13 PIK50087.1 - 0.053 13.9 0.4 36 4.8 0.0 3.1 3 0 0 3 3 3 0 Recombinase HapK PF11639.8 PIK50087.1 - 0.057 13.9 0.2 50 4.5 0.0 3.2 3 0 0 3 3 3 0 REDY-like protein HapK Transpos_assoc PF13963.6 PIK50087.1 - 0.063 13.6 2.1 62 4.0 0.1 3.2 3 0 0 3 3 3 0 Transposase-associated domain Cyanate_lyase PF02560.14 PIK50087.1 - 0.095 12.6 2.0 58 3.6 0.1 3.2 3 0 0 3 3 3 0 Cyanate lyase C-terminal domain CAP18_C PF12153.8 PIK50087.1 - 0.13 12.1 6.8 31 4.6 0.2 3.6 3 0 0 3 3 3 0 LPS binding domain of CAP18 (C terminal) DapH_N PF08503.10 PIK50087.1 - 0.15 12.3 0.9 1.1e+02 3.1 0.0 3.2 3 0 0 3 3 3 0 Tetrahydrodipicolinate succinyltransferase N-terminal FumaraseC_C PF10415.9 PIK50087.1 - 0.2 12.1 1.1 87 3.6 0.0 3.2 3 0 0 3 3 3 0 Fumarase C C-terminus EssA PF10661.9 PIK50087.1 - 0.44 10.4 5.0 19 5.1 0.3 3.3 1 1 2 3 3 3 0 WXG100 protein secretion system (Wss), protein EssA rve PF00665.26 PIK50088.1 - 1.3e-12 47.9 0.0 1e-11 45.1 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK50088.1 - 0.023 14.5 0.0 0.059 13.2 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain MLVIN_C PF18697.1 PIK50088.1 - 0.033 14.3 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Pec_lyase_N PF04431.13 PIK50088.1 - 0.068 13.4 0.4 0.28 11.4 0.2 2.0 2 0 0 2 2 2 0 Pectate lyase, N terminus RVT_2 PF07727.14 PIK50089.1 - 1.4e-18 67.4 0.1 2e-18 66.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK50090.1 - 3.5e-23 81.5 0.1 9.6e-23 80.1 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50090.1 - 2.9e-11 43.6 0.0 8.9e-11 42.0 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50090.1 - 7.1e-06 25.7 0.1 1.5e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK50090.1 - 0.00059 20.4 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK50090.1 - 0.0014 19.1 0.0 0.0037 17.8 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Cys_Knot_tox PF17486.2 PIK50090.1 - 7.4 6.9 10.2 0.19 12.0 1.6 2.4 2 0 0 2 2 2 0 Cystine knot toxins Retrotrans_gag PF03732.17 PIK50091.1 - 0.025 14.9 0.1 0.056 13.7 0.1 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC PF00098.23 PIK50091.1 - 0.025 14.6 1.1 0.025 14.6 1.1 2.8 3 0 0 3 3 3 0 Zinc knuckle RVP PF00077.20 PIK50091.1 - 0.073 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease FYDLN_acid PF09538.10 PIK50091.1 - 2.5 8.8 10.5 4.4 8.0 10.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zinc-ribbons_6 PF07191.12 PIK50091.1 - 2.7 8.1 11.2 0.62 10.1 6.1 2.2 2 0 0 2 2 2 0 zinc-ribbons zf-CCHC_4 PF14392.6 PIK50091.1 - 9.4 6.1 7.2 23 4.8 1.7 2.5 2 0 0 2 2 2 0 Zinc knuckle MyTH4 PF00784.17 PIK50092.1 - 6.7e-15 55.5 0.0 1.2e-14 54.7 0.0 1.4 1 1 0 1 1 1 1 MyTH4 domain RhoGAP PF00620.27 PIK50092.1 - 0.00026 20.8 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.26 PIK50094.1 - 1e-05 25.5 3.4 2.6e-05 24.2 3.4 1.8 1 0 0 1 1 1 1 WW domain SelP_N PF04592.14 PIK50094.1 - 0.0066 15.9 16.6 0.0066 15.9 16.6 2.4 2 0 0 2 2 2 1 Selenoprotein P, N terminal region DUF775 PF05603.12 PIK50095.1 - 6.4e-49 166.2 1.8 1e-48 165.5 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Death PF00531.22 PIK50096.1 - 1.8e-08 34.4 0.7 2.8e-08 33.8 0.7 1.3 1 0 0 1 1 1 1 Death domain CTD_bind PF04818.13 PIK50096.1 - 0.078 13.8 0.1 0.16 12.8 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase II-binding domain. SH3_2 PF07653.17 PIK50098.1 - 0.096 12.4 0.1 0.84 9.4 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain Death PF00531.22 PIK50099.1 - 1.7e-08 34.5 0.3 2e-08 34.2 0.3 1.1 1 0 0 1 1 1 1 Death domain DUF550 PF04447.12 PIK50099.1 - 0.18 12.0 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF550) TPP_enzyme_C PF02775.21 PIK50100.1 - 0.00038 20.3 0.0 0.00054 19.8 0.0 1.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_N PF02776.18 PIK50101.1 - 1.4e-47 161.5 1.3 2.6e-47 160.6 1.3 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 PIK50101.1 - 7.2e-17 61.4 0.1 2.8e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 PIK50101.1 - 0.031 14.1 0.0 0.069 12.9 0.0 1.6 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit T7SS_ESX_EspC PF10824.8 PIK50101.1 - 0.072 13.6 0.9 0.19 12.2 0.9 1.6 1 0 0 1 1 1 0 Excreted virulence factor EspC, type VII ESX diderm RVT_1 PF00078.27 PIK50102.1 - 1.5e-08 34.5 0.0 3e-08 33.4 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Death PF00531.22 PIK50103.1 - 4.9e-07 29.8 0.3 9.9e-07 28.8 0.3 1.5 1 0 0 1 1 1 1 Death domain DUF2406 PF10295.9 PIK50103.1 - 0.21 12.3 3.2 26 5.6 0.0 3.5 4 1 1 5 5 5 0 Uncharacterised protein (DUF2406) SH3_2 PF07653.17 PIK50104.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.17 PIK50105.1 - 0.88 9.3 2.7 0.91 9.3 0.0 2.4 3 1 0 3 3 3 0 Variant SH3 domain GPS PF01825.21 PIK50106.1 - 2.3e-19 69.6 2.3 4.7e-19 68.6 2.3 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK50106.1 - 5.9e-18 65.1 14.7 8.2e-18 64.6 14.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Arv1 PF04161.13 PIK50106.1 - 0.021 15.0 4.8 0.032 14.4 4.8 1.3 1 0 0 1 1 1 0 Arv1-like family Frizzled PF01534.17 PIK50106.1 - 0.028 13.5 16.2 0.056 12.5 15.7 1.7 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF5367 PF17329.2 PIK50106.1 - 3.3 7.9 9.5 7.6 6.7 1.8 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5367) RVT_1 PF00078.27 PIK50107.1 - 1.3e-41 142.5 0.0 2.4e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_3 PF12947.7 PIK50108.1 - 0.025 14.8 4.5 0.053 13.7 4.5 1.6 1 0 0 1 1 1 0 EGF domain FXa_inhibition PF14670.6 PIK50108.1 - 0.042 14.1 4.0 0.12 12.6 4.0 1.8 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK50108.1 - 0.068 13.4 6.8 0.21 11.8 6.8 1.9 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF PF00008.27 PIK50108.1 - 0.73 10.2 5.3 0.68 10.3 3.1 2.1 2 0 0 2 2 2 0 EGF-like domain EB PF01683.18 PIK50108.1 - 8.3 6.8 10.2 3.2 8.1 7.1 1.9 2 0 0 2 2 2 0 EB module DMPK_coil PF08826.10 PIK50109.1 - 0.007 16.5 3.3 0.007 16.5 3.3 11.3 8 4 3 12 12 12 1 DMPK coiled coil domain like Lzipper-MIP1 PF14389.6 PIK50109.1 - 0.007 16.6 7.6 0.007 16.6 7.6 8.5 7 2 1 8 8 8 2 Leucine-zipper of ternary complex factor MIP1 Filament PF00038.21 PIK50109.1 - 0.014 15.0 100.2 0.11 12.1 49.7 4.7 1 1 2 3 3 3 0 Intermediate filament protein ATG16 PF08614.11 PIK50109.1 - 0.15 12.3 119.7 0.33 11.1 18.2 6.3 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) WD40_alt PF14077.6 PIK50109.1 - 0.4 10.6 3.3 3.7 7.5 0.0 3.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif Fez1 PF06818.15 PIK50109.1 - 0.64 10.4 109.0 0.036 14.5 17.8 5.6 1 1 4 5 5 5 0 Fez1 CENP-F_leu_zip PF10473.9 PIK50110.1 - 0.0017 18.4 13.6 0.0017 18.4 13.6 3.4 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF496 PF04363.12 PIK50110.1 - 0.0024 17.8 1.4 0.0024 17.8 1.4 3.4 2 2 0 3 3 3 2 Protein of unknown function (DUF496) DUF1664 PF07889.12 PIK50110.1 - 0.019 15.0 3.8 0.019 15.0 3.8 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 PIK50110.1 - 0.045 14.0 45.7 0.42 10.8 7.6 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 PIK50110.1 - 0.36 10.9 41.0 0.53 10.4 7.8 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding CCDC144C PF14915.6 PIK50110.1 - 0.47 9.5 41.2 3.2e+02 0.2 41.2 3.1 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region HAP1_N PF04849.13 PIK50110.1 - 4.4 6.4 37.8 0.07 12.3 12.1 3.3 1 1 2 3 3 3 0 HAP1 N-terminal conserved region Lebercilin PF15619.6 PIK50110.1 - 6.1 6.5 45.4 3 7.4 13.6 3.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Laminin_II PF06009.12 PIK50110.1 - 7.6 6.6 30.1 0.1 12.6 3.6 3.3 1 1 1 3 3 3 0 Laminin Domain II Tropomyosin PF00261.20 PIK50110.1 - 9.7 5.5 46.4 0.62 9.4 10.8 3.3 1 1 1 3 3 3 0 Tropomyosin DUF3128 PF11326.8 PIK50112.1 - 5.2e-17 62.0 5.9 6.9e-17 61.6 5.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Pyridoxal_deC PF00282.19 PIK50113.1 - 3.5e-143 476.9 0.0 4.2e-143 476.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain EMP24_GP25L PF01105.24 PIK50114.1 - 4.1e-49 167.0 0.1 4.6e-49 166.8 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3952 PF13130.6 PIK50114.1 - 0.037 14.2 0.1 0.069 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3952) 4HFCP_synth PF04476.13 PIK50114.1 - 0.076 12.7 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 4-HFC-P synthase Jnk-SapK_ap_N PF09744.9 PIK50115.1 - 4.4e-17 62.7 16.0 4.4e-17 62.7 16.0 4.2 3 2 1 4 4 4 1 JNK_SAPK-associated protein-1 RILP PF11461.8 PIK50115.1 - 5.4e-06 26.5 0.9 5.4e-06 26.5 0.9 4.4 5 0 0 5 5 5 1 Rab interacting lysosomal protein TSNAXIP1_N PF15739.5 PIK50115.1 - 0.031 14.7 17.8 0.037 14.4 1.7 3.6 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus Sec34 PF04136.15 PIK50115.1 - 0.071 13.0 14.0 0.84 9.5 0.9 2.7 2 0 0 2 2 2 0 Sec34-like family PRY PF13765.6 PIK50115.1 - 0.08 12.6 0.1 0.2 11.3 0.1 1.7 1 0 0 1 1 1 0 SPRY-associated domain DUF948 PF06103.11 PIK50115.1 - 8.1 6.8 11.5 6.2 7.1 4.8 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FAD_binding_1 PF00667.20 PIK50116.1 - 3.2e-77 259.1 0.0 6e-77 258.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 PIK50116.1 - 4e-35 121.1 1.8 5.2e-35 120.7 0.8 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 PIK50116.1 - 1.1e-18 67.9 0.0 2.9e-18 66.5 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Glyco_tran_WecB PF03808.13 PIK50116.1 - 0.19 11.7 0.0 0.65 9.9 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Med19 PF10278.9 PIK50117.1 - 1.9e-49 168.0 7.2 2.5e-49 167.6 7.2 1.1 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 His_Phos_1 PF00300.22 PIK50118.1 - 8.3e-18 64.8 0.0 5.9e-16 58.7 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF383 PF04063.14 PIK50119.1 - 3e-58 196.6 0.0 1.2e-57 194.7 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 PIK50119.1 - 1.7e-18 66.2 0.0 5.3e-18 64.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Adaptin_N PF01602.20 PIK50119.1 - 0.0011 17.6 1.2 0.018 13.6 0.3 2.5 2 1 0 2 2 2 1 Adaptin N terminal region HEAT_2 PF13646.6 PIK50119.1 - 0.0016 18.8 0.1 0.87 10.0 0.0 4.0 3 1 0 3 3 3 1 HEAT repeats Mo25 PF08569.11 PIK50119.1 - 0.018 14.4 0.1 0.038 13.3 0.0 1.6 2 0 0 2 2 2 0 Mo25-like NPA PF16469.5 PIK50119.1 - 0.05 14.2 0.1 0.22 12.1 0.1 2.1 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Arm PF00514.23 PIK50119.1 - 0.1 12.7 1.1 30 4.8 0.0 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat CBF PF03914.17 PIK50120.1 - 3.5e-30 105.3 1.3 3.5e-30 105.3 1.3 1.9 2 0 0 2 2 2 1 CBF/Mak21 family RRM_1 PF00076.22 PIK50121.1 - 1.3e-10 41.0 0.0 3.5e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) F-box-like PF12937.7 PIK50121.1 - 8.1e-10 38.4 0.2 1.8e-09 37.3 0.2 1.6 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 PIK50121.1 - 1.7e-08 33.8 4.2 0.00066 19.5 0.0 6.9 8 0 0 8 8 8 1 Leucine Rich repeat F-box PF00646.33 PIK50121.1 - 3.5e-06 26.8 0.4 1e-05 25.3 0.4 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 PIK50121.1 - 7e-06 26.3 7.3 0.12 12.8 0.1 6.4 5 2 1 6 6 6 2 Leucine Rich repeats (2 copies) AdoMet_MTase PF07757.13 PIK50122.1 - 4.7e-31 107.4 0.1 8.8e-31 106.5 0.1 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MTS PF05175.14 PIK50122.1 - 0.18 11.3 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PH PF00169.29 PIK50123.1 - 5.8e-17 62.1 0.2 2.6e-16 60.0 0.0 2.0 2 0 0 2 2 2 1 PH domain zf-CHC2 PF01807.20 PIK50123.1 - 0.16 11.8 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 CHC2 zinc finger PH PF00169.29 PIK50124.1 - 9.7e-17 61.4 0.2 3.9e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 PH domain zf-CHC2 PF01807.20 PIK50124.1 - 0.13 12.1 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 CHC2 zinc finger 7tm_1 PF00001.21 PIK50125.1 - 1.3e-22 80.4 10.7 1.4e-22 80.3 10.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK50125.1 - 1.1e-12 48.2 16.6 1.4e-12 47.8 16.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK50125.1 - 1.9e-06 27.4 13.8 3.1e-06 26.8 13.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 PIK50125.1 - 0.093 12.2 18.4 0.02 14.4 12.7 1.9 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc BRI3BP PF14965.6 PIK50125.1 - 5 6.6 7.8 24 4.4 3.8 2.2 2 0 0 2 2 2 0 Negative regulator of p53/TP53 Ras PF00071.22 PIK50126.1 - 5.8e-45 152.8 0.9 7.5e-45 152.4 0.9 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK50126.1 - 3.6e-30 104.6 0.7 6e-30 103.9 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK50126.1 - 6.4e-11 42.0 0.0 8.7e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK50126.1 - 2.6e-06 27.5 0.0 4.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK50126.1 - 0.00026 20.4 0.2 0.00043 19.7 0.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK50126.1 - 0.00088 18.9 0.1 0.073 12.6 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 PIK50126.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 PIK50126.1 - 0.025 14.3 0.0 0.1 12.4 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF4110 PF13422.6 PIK50126.1 - 0.063 13.4 0.4 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) AAA_16 PF13191.6 PIK50126.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 PIK50126.1 - 0.15 11.6 0.5 0.3 10.6 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 PIK50126.1 - 0.16 11.9 0.1 9.8 6.0 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase Ribosomal_L23eN PF03939.13 PIK50127.1 - 3.1e-19 68.9 11.6 9.5e-19 67.4 11.6 1.9 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 PIK50127.1 - 2e-14 53.7 2.8 2e-14 53.7 2.8 1.8 2 1 0 2 2 2 1 Ribosomal protein L23 DUF5451 PF17532.2 PIK50127.1 - 0.39 11.0 6.0 0.26 11.6 4.7 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5451) RRM_1 PF00076.22 PIK50128.1 - 1.4e-33 114.5 0.3 1.7e-15 56.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK50128.1 - 3.5e-11 43.1 0.5 0.00026 21.0 0.1 2.9 2 2 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK50128.1 - 0.022 14.8 0.2 1.5 8.9 0.2 2.6 2 1 0 2 2 2 0 RNA binding motif Lambda_Bor PF06291.11 PIK50128.1 - 0.094 12.8 0.4 0.37 10.9 0.0 2.2 3 0 0 3 3 3 0 Bor protein NID PF07292.13 PIK50128.1 - 0.17 12.5 0.9 24 5.7 0.3 2.5 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) Ig_3 PF13927.6 PIK50129.1 - 1e-25 90.1 1.5 3.1e-14 53.3 0.3 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK50129.1 - 2.7e-23 81.8 0.0 1.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK50129.1 - 2e-18 66.5 0.3 3.3e-08 33.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK50129.1 - 2.7e-15 56.3 0.2 2.5e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK50129.1 - 6.8e-08 32.6 1.4 0.043 14.0 0.0 4.1 2 2 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK50129.1 - 5.8e-05 23.1 0.3 0.0014 18.6 0.1 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK50129.1 - 0.00021 20.8 0.0 0.21 11.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK50129.1 - 0.024 15.0 0.1 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK50129.1 - 0.09 13.0 0.0 23 5.4 0.0 2.8 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK50130.1 - 2.9e-92 302.9 1.3 5.8e-16 58.3 0.0 8.6 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK50130.1 - 2.7e-89 293.9 10.8 2.1e-15 57.1 0.1 8.8 7 1 1 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.6 PIK50130.1 - 2.4e-60 200.8 7.5 4.3e-12 46.2 0.1 7.5 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 PIK50130.1 - 8.9e-55 182.8 8.0 1.4e-10 41.2 0.0 8.2 8 0 0 8 8 7 7 Immunoglobulin domain V-set PF07686.17 PIK50130.1 - 2.7e-32 111.2 11.9 0.00061 19.9 0.1 10.5 7 4 1 8 8 8 7 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK50130.1 - 1.7e-15 57.2 0.0 0.0012 19.2 0.0 7.6 8 0 0 8 8 8 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK50130.1 - 3.4e-14 52.1 0.0 0.028 14.0 0.0 6.2 7 0 0 7 7 7 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK50130.1 - 2.8e-13 49.7 10.2 0.045 13.8 0.0 7.1 8 0 0 8 8 6 4 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 PIK50130.1 - 1.2e-12 47.7 0.5 0.0074 16.3 0.0 6.9 7 0 0 7 7 7 3 C17orf99 Ig domain Ig_4 PF16680.5 PIK50130.1 - 3.5e-11 43.2 1.6 0.022 15.0 0.0 7.4 8 0 0 8 8 7 2 T-cell surface glycoprotein CD3 delta chain fn3 PF00041.21 PIK50130.1 - 2.8e-10 40.4 1.4 0.00066 20.0 0.0 4.0 3 0 0 3 3 3 2 Fibronectin type III domain Izumo-Ig PF16706.5 PIK50130.1 - 5.7e-07 29.5 0.2 1.8 8.7 0.0 7.0 8 1 0 8 8 8 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK50130.1 - 0.00061 19.5 0.0 2.4 8.0 0.0 4.6 5 0 0 5 5 5 1 Adenovirus E3 region protein CR1 DUF2207 PF09972.9 PIK50130.1 - 0.028 13.2 0.9 0.068 11.9 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) UL141 PF16758.5 PIK50130.1 - 0.082 12.6 0.1 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Herpes-like virus membrane glycoprotein UL141 SIT PF15330.6 PIK50130.1 - 0.088 13.3 0.4 1 9.8 0.0 2.5 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Protocadherin PF08374.11 PIK50130.1 - 1.4 8.9 0.0 1.4 8.9 0.0 2.9 3 0 0 3 3 3 0 Protocadherin Peptidase_S49_N PF08496.10 PIK50130.1 - 1.6 8.8 6.3 5.3 7.1 2.1 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal C2-set PF05790.15 PIK50130.1 - 9.4 6.5 7.4 2.3 8.4 0.1 4.0 6 0 0 6 6 3 0 Immunoglobulin C2-set domain Ufd2P_core PF10408.9 PIK50131.1 - 7.6e-132 441.0 12.7 5.2e-71 240.1 0.1 2.4 2 1 1 3 3 3 2 Ubiquitin elongating factor core U-box PF04564.15 PIK50131.1 - 1.3e-26 92.5 0.9 4.2e-26 90.9 0.9 1.9 1 0 0 1 1 1 1 U-box domain DUF445 PF04286.12 PIK50131.1 - 0.045 13.6 1.3 0.13 12.1 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) ABC2_membrane_3 PF12698.7 PIK50133.1 - 4.2e-57 193.8 51.3 4.1e-38 131.4 15.9 3.1 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.27 PIK50133.1 - 9.1e-49 165.5 0.0 1.2e-26 93.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 PIK50133.1 - 2.3e-19 70.4 1.2 2.6e-06 27.5 0.0 4.6 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 PIK50133.1 - 0.017 15.8 0.1 2.2 9.1 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_29 PF13555.6 PIK50133.1 - 0.064 13.0 1.7 0.92 9.3 0.2 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_15 PF13175.6 PIK50133.1 - 0.075 12.7 4.9 2.7 7.6 0.1 3.0 4 0 0 4 4 4 0 AAA ATPase domain SRP54 PF00448.22 PIK50133.1 - 0.12 12.0 4.2 5.7 6.5 0.4 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 PIK50133.1 - 0.14 12.3 0.6 13 5.9 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 PIK50133.1 - 0.55 10.7 11.1 0.27 11.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain MukB PF04310.12 PIK50133.1 - 0.57 10.0 2.3 1.6 8.5 0.1 2.2 2 0 0 2 2 2 0 MukB N-terminal AAA_30 PF13604.6 PIK50133.1 - 0.96 9.1 2.2 7.4 6.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain Integrase_H2C2 PF17921.1 PIK50134.1 - 2.8e-18 65.8 0.0 4.8e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK50134.1 - 7.9e-13 48.3 0.0 2.1e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK50134.1 - 9.6e-13 48.4 0.0 2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK50134.1 - 4.3e-05 23.6 0.0 9.5e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH PF17917.1 PIK50134.1 - 0.00019 21.7 0.0 0.063 13.6 0.0 3.4 3 1 1 4 4 4 1 RNase H-like domain found in reverse transcriptase IMCp PF12314.8 PIK50135.1 - 7.3e-06 26.2 4.2 0.044 14.1 0.1 3.3 1 1 1 2 2 2 2 Inner membrane complex protein DUF1629 PF07791.11 PIK50135.1 - 0.014 15.5 7.4 2.6 8.2 0.2 5.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1629) Drf_FH1 PF06346.12 PIK50135.1 - 0.098 12.4 13.7 0.25 11.1 7.3 2.5 1 1 2 3 3 3 0 Formin Homology Region 1 DUF1473 PF07341.11 PIK50135.1 - 0.96 9.2 2.6 40 3.9 0.1 3.4 1 1 2 4 4 4 0 Protein of unknown function (DUF1473) Glyco_transf_29 PF00777.18 PIK50136.1 - 3.2e-62 210.4 0.0 3.8e-62 210.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PhosphMutase PF10143.9 PIK50136.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Drf_FH1 PF06346.12 PIK50136.1 - 1.6 8.4 3.3 2.7 7.7 3.3 1.4 1 0 0 1 1 1 0 Formin Homology Region 1 Choline_transpo PF04515.12 PIK50137.1 - 6.5e-62 209.6 26.3 6.5e-62 209.6 26.3 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter Choline_transpo PF04515.12 PIK50138.1 - 4.9e-100 334.9 40.1 4.9e-100 334.9 40.1 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter PID PF00640.23 PIK50139.1 - 1.3e-24 86.9 1.5 1.3e-24 86.9 1.5 1.6 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) TilS PF09179.11 PIK50139.1 - 0.043 14.3 1.8 0.082 13.4 1.8 1.4 1 0 0 1 1 1 0 TilS substrate binding domain Pkinase PF00069.25 PIK50140.1 - 8.2e-56 189.3 0.1 8.2e-56 189.3 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50140.1 - 9.1e-35 120.2 0.7 9.1e-35 120.2 0.7 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 PIK50140.1 - 0.0014 18.1 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK50140.1 - 0.0016 18.4 0.0 0.051 13.5 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK50140.1 - 0.011 15.4 1.1 0.13 11.9 0.0 2.8 3 0 0 3 3 3 0 RIO1 family Kinase-like PF14531.6 PIK50140.1 - 0.018 14.4 3.3 0.051 12.9 0.0 2.8 2 1 1 3 3 3 0 Kinase-like Pkinase_fungal PF17667.1 PIK50140.1 - 0.03 13.1 0.0 0.062 12.1 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 PIK50140.1 - 0.069 12.8 3.1 0.34 10.5 0.3 2.7 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 EF-hand_1 PF00036.32 PIK50141.1 - 1.4e-11 43.1 3.0 1.7e-05 24.0 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK50141.1 - 1.5e-11 44.6 0.4 2.3e-11 44.0 0.2 1.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK50141.1 - 4.1e-10 38.8 1.8 1.4e-05 24.6 0.3 2.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK50141.1 - 3e-09 36.0 3.4 1e-05 24.8 1.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK50141.1 - 3.5e-07 30.0 0.6 0.0067 16.2 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK50141.1 - 1.7e-06 28.3 0.1 1.9e-06 28.2 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK50141.1 - 0.00028 20.8 0.0 0.09 12.7 0.0 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 PIK50141.1 - 0.00043 20.4 1.7 0.023 14.9 0.5 2.3 1 1 1 2 2 2 2 Dockerin type I domain IL17 PF06083.11 PIK50142.1 - 1.9e-24 85.9 2.1 3.5e-24 85.1 2.1 1.4 1 0 0 1 1 1 1 Interleukin-17 IL17 PF06083.11 PIK50144.1 - 4.2e-23 81.6 1.5 8.2e-23 80.7 1.5 1.4 1 0 0 1 1 1 1 Interleukin-17 DUF4455 PF14643.6 PIK50145.1 - 2.1e-137 458.6 33.5 2.1e-137 458.6 33.5 3.8 2 2 1 3 3 3 2 Domain of unknown function (DUF4455) DUF5329 PF17263.2 PIK50145.1 - 0.046 13.9 0.1 0.19 11.9 0.1 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5329) DUF4806 PF16064.5 PIK50145.1 - 0.055 13.8 0.8 13 6.1 0.2 4.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4806) Phage_int_SAM_5 PF13102.6 PIK50145.1 - 0.21 11.9 6.4 0.9 9.9 0.2 4.4 5 0 0 5 5 5 0 Phage integrase SAM-like domain POX PF07526.11 PIK50145.1 - 5.4 7.6 11.8 2.4 8.8 1.3 3.5 3 0 0 3 3 3 0 Associated with HOX DUF4456 PF14644.6 PIK50146.1 - 3e-61 206.8 7.3 4.8e-61 206.1 7.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4456) DUF2935 PF11155.8 PIK50146.1 - 0.033 14.5 0.9 0.17 12.3 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Apolipoprotein PF01442.18 PIK50146.1 - 0.048 13.5 10.0 0.26 11.1 2.1 3.1 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain Med21 PF11221.8 PIK50146.1 - 0.074 13.3 2.1 0.48 10.7 0.0 2.6 3 0 0 3 3 3 0 Subunit 21 of Mediator complex DUF2730 PF10805.8 PIK50146.1 - 0.1 12.7 0.1 0.25 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) FRB_dom PF08771.11 PIK50146.1 - 0.25 11.8 0.1 0.25 11.8 0.1 3.2 3 2 0 3 3 3 0 FKBP12-rapamycin binding domain YlqD PF11068.8 PIK50146.1 - 0.28 11.5 13.4 0.14 12.5 1.8 3.1 2 1 1 3 3 3 0 YlqD protein Exonuc_VII_L PF02601.15 PIK50146.1 - 0.3 10.6 4.8 0.079 12.5 1.9 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit DMAP1 PF05499.12 PIK50147.1 - 1.4e-61 207.1 4.3 3.5e-61 205.9 4.3 1.6 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.5 PIK50147.1 - 6.5e-31 106.4 1.6 1.7e-30 105.0 1.6 1.8 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 NACHT_N PF17100.5 PIK50147.1 - 2.8 7.7 6.8 4.6 7.0 5.7 1.9 1 1 1 2 2 2 0 N-terminal domain of NWD NACHT-NTPase MCPVI PF02993.14 PIK50147.1 - 7 6.4 6.4 2.6 7.8 1.5 2.1 2 0 0 2 2 2 0 Minor capsid protein VI SHIPPO-rpt PF07004.12 PIK50148.1 - 9.1e-11 42.1 8.9 0.033 15.1 0.2 6.6 6 0 0 6 6 6 6 Sperm-tail PG-rich repeat PAC3 PF10178.9 PIK50149.1 - 1.6e-19 69.8 0.0 1.7e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 RRM_1 PF00076.22 PIK50150.1 - 1.4e-18 66.5 0.1 4.9e-12 45.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK50150.1 - 0.0038 17.2 2.3 0.95 9.5 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 PIK50150.1 - 0.01 15.4 0.0 0.26 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF755 PF05501.11 PIK50150.1 - 0.036 14.3 5.6 0.058 13.7 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF441 PF04284.13 PIK50150.1 - 0.037 14.0 0.3 0.069 13.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF441) RRM_occluded PF16842.5 PIK50150.1 - 0.078 12.8 0.0 0.59 10.0 0.0 2.3 2 1 0 2 2 2 0 Occluded RNA-recognition motif FAM60A PF15396.6 PIK50151.1 - 1.4 8.9 13.4 2.5 8.1 13.4 1.4 1 0 0 1 1 1 0 Protein Family FAM60A PNP_UDP_1 PF01048.20 PIK50152.1 - 1.9e-16 60.1 0.0 2.4e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 PIK50153.1 - 1.5e-18 66.9 0.0 1.9e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily PID PF00640.23 PIK50154.1 - 1.2e-06 28.6 0.4 2.7e-06 27.5 0.1 1.5 1 1 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PRKCSH_1 PF13015.6 PIK50155.1 - 8.1e-27 93.8 0.8 8.1e-27 93.8 0.8 2.4 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 PIK50155.1 - 9.8e-10 39.3 3.2 9.8e-10 39.3 3.2 2.6 3 1 0 3 3 3 1 Glucosidase II beta subunit-like protein EF-hand_1 PF00036.32 PIK50155.1 - 2.1e-05 23.8 0.0 0.00046 19.5 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK50155.1 - 2.2e-05 24.8 6.5 0.0019 18.6 0.2 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK50155.1 - 0.00063 19.1 0.1 0.002 17.5 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK50155.1 - 0.0011 18.7 0.1 0.013 15.3 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain ING PF12998.7 PIK50155.1 - 0.15 12.7 15.1 0.62 10.7 3.0 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Atrophin-1 PF03154.15 PIK50155.1 - 0.54 8.5 4.8 0.82 7.9 4.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family RVT_1 PF00078.27 PIK50157.1 - 4e-19 69.0 0.1 6.5e-19 68.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK50157.1 - 0.079 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) MerR-DNA-bind PF09278.11 PIK50157.1 - 0.13 12.8 0.0 0.67 10.5 0.0 2.0 2 0 0 2 2 2 0 MerR, DNA binding Calici_coat PF00915.20 PIK50158.1 - 0.069 12.0 0.2 6.3 5.6 0.0 2.1 2 0 0 2 2 2 0 Calicivirus coat protein VGLL4 PF15245.6 PIK50158.1 - 0.14 12.3 5.2 2.8 8.0 0.6 2.1 1 1 1 2 2 2 0 Transcription cofactor vestigial-like protein 4 DUF559 PF04480.12 PIK50160.1 - 0.032 14.1 0.3 7.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF559) C2-set_2 PF08205.12 PIK50160.1 - 0.033 14.3 9.5 2.5 8.2 0.3 3.7 3 2 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Syntaphilin PF15290.6 PIK50160.1 - 0.074 12.7 0.2 4.6 6.8 0.1 2.0 2 0 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp Pkinase_Tyr PF07714.17 PIK50162.1 - 3.6e-21 75.6 0.1 5.6e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50162.1 - 6.2e-16 58.5 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK50162.1 - 3e-06 27.2 1.2 0.049 13.7 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK50162.1 - 4.6e-05 23.9 3.4 0.14 12.7 0.1 3.7 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK50162.1 - 0.00023 21.5 2.5 0.41 11.1 0.1 3.8 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Pkinase_Tyr PF07714.17 PIK50163.1 - 4e-48 164.0 0.0 5.9e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50163.1 - 4.9e-18 65.4 0.0 7.5e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50164.1 - 1.1e-47 162.5 0.1 1.8e-47 161.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50164.1 - 7.4e-19 68.1 0.1 1.4e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK50164.1 - 2.6e-06 27.9 1.8 0.035 14.7 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK50164.1 - 0.00065 19.8 2.3 0.15 12.3 0.1 3.2 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK50164.1 - 0.012 15.6 0.3 0.47 10.6 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK50164.1 - 0.07 13.2 3.8 0.23 11.6 0.3 2.9 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK50164.1 - 0.078 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK50164.1 - 0.57 10.4 3.9 0.63 10.2 0.2 2.9 3 2 1 4 4 4 0 Immunoglobulin V-set domain UCH PF00443.29 PIK50165.1 - 1.4e-35 123.1 0.0 2e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK50165.1 - 3.5e-11 43.3 2.1 7.5e-06 25.8 0.1 2.6 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase SAT PF16073.5 PIK50165.1 - 0.026 14.3 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis DNA_RNApol_7kD PF03604.13 PIK50165.1 - 0.11 12.1 2.9 2.8 7.7 0.3 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit MAM PF00629.23 PIK50166.1 - 1.1e-112 373.2 0.5 2.7e-37 128.2 0.0 4.1 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu MAM PF00629.23 PIK50167.1 - 2.6e-38 131.5 0.0 8.6e-18 64.8 0.0 3.0 3 0 0 3 3 3 3 MAM domain, meprin/A5/mu MAM PF00629.23 PIK50168.1 - 3.6e-101 335.8 0.0 7e-40 136.6 1.7 4.6 5 0 0 5 5 5 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK50168.1 - 1.8e-14 53.7 22.2 2.9e-08 33.8 13.1 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK50169.1 - 1.8e-157 518.8 0.0 6.5e-40 136.7 0.1 5.0 5 0 0 5 5 5 5 MAM domain, meprin/A5/mu MAM PF00629.23 PIK50170.1 - 4.7e-16 59.1 0.0 6.7e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 PIK50171.1 - 9.5e-102 337.7 0.1 5.5e-26 91.4 0.0 4.1 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK50171.1 - 5.2e-08 33.0 24.7 0.00059 20.0 5.0 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK50172.1 - 5.5e-41 140.2 0.0 8.1e-41 139.6 0.0 1.2 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 PIK50173.1 - 2e-255 837.2 0.0 1.1e-41 142.4 0.0 9.2 9 0 0 9 9 9 9 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK50173.1 - 6.1e-09 35.9 36.5 9.9e-06 25.7 12.7 3.1 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK50174.1 - 1.6e-106 353.2 4.2 1.1e-34 119.6 0.2 4.2 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK50174.1 - 4.5e-06 26.8 48.8 0.00058 20.0 8.6 4.0 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A TMEM154 PF15102.6 PIK50174.1 - 1.2e-05 25.3 0.1 2.3e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 PIK50174.1 - 0.07 12.5 0.2 0.12 11.7 0.2 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF3481 PF11980.8 PIK50174.1 - 0.23 11.2 2.6 0.49 10.1 2.6 1.4 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Insulin_TMD PF17870.1 PIK50174.1 - 2.3 8.4 5.6 4.8 7.3 5.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DDE_Tnp_4 PF13359.6 PIK50175.1 - 1.4e-32 112.5 0.0 1.7e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 PIK50175.1 - 2.8e-08 33.7 0.0 2.6e-06 27.3 0.0 2.1 1 1 0 1 1 1 1 Transposase DDE domain Plant_tran PF04827.14 PIK50175.1 - 6.6e-07 29.1 0.0 5.5e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Plant transposon protein CLTH PF10607.9 PIK50176.1 - 2.4e-37 128.1 0.0 3.9e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 PIK50176.1 - 2.3e-21 76.1 1.3 5.7e-21 74.9 0.1 2.1 2 0 0 2 2 2 1 SPRY domain LisH PF08513.11 PIK50176.1 - 1.2e-05 25.0 0.0 2.9e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 LisH MCC-bdg_PDZ PF10506.9 PIK50176.1 - 0.0042 17.1 0.1 0.0099 15.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome ROK PF00480.20 PIK50176.1 - 0.043 13.3 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 ROK family Retrotran_gag_2 PF14223.6 PIK50177.1 - 0.0003 20.5 2.9 0.00061 19.5 2.9 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type ASL_C PF08328.11 PIK50177.1 - 0.037 14.1 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DUF2524 PF10732.9 PIK50177.1 - 9.4 6.6 9.9 1.1 9.6 1.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2524) RGS PF00615.19 PIK50178.1 - 1.7e-32 112.2 0.2 2.9e-32 111.4 0.2 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain G-gamma PF00631.22 PIK50178.1 - 7.3e-10 38.7 0.0 2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 GGL domain Methyltransf_16 PF10294.9 PIK50179.1 - 7.3e-17 61.6 0.4 2e-08 34.2 0.0 2.6 3 0 0 3 3 3 2 Lysine methyltransferase FAM86 PF14904.6 PIK50179.1 - 3.8e-10 39.7 0.3 8.8e-10 38.5 0.3 1.6 1 0 0 1 1 1 1 Family of unknown function MTS PF05175.14 PIK50179.1 - 0.00044 19.8 0.0 0.00072 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 PIK50179.1 - 0.041 14.6 0.0 0.12 13.1 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK50179.1 - 0.053 13.4 1.0 0.17 11.7 0.4 2.2 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 PIK50179.1 - 0.12 13.1 0.1 0.55 11.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain CDRT4 PF15213.6 PIK50180.1 - 1.4 9.5 8.4 5 7.7 1.9 2.3 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein APG6_N PF17675.1 PIK50181.1 - 1.3e-11 45.2 143.4 0.056 14.0 20.2 6.0 1 1 3 4 4 3 3 Apg6 coiled-coil region ERM PF00769.19 PIK50181.1 - 5.3e-11 42.8 149.1 0.00041 20.2 37.0 4.1 1 1 3 4 4 4 4 Ezrin/radixin/moesin family GAS PF13851.6 PIK50181.1 - 5e-09 35.8 118.2 0.0033 16.8 21.5 5.4 1 1 6 7 7 7 7 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 PIK50181.1 - 0.00019 21.3 124.9 1.2 9.0 15.1 6.7 1 1 5 6 6 6 4 Coiled-coil region of CCDC155 or KASH DUF4600 PF15372.6 PIK50181.1 - 0.0038 17.7 92.8 0.5 10.8 10.6 7.2 1 1 6 7 7 7 2 Domain of unknown function (DUF4600) DUF4472 PF14739.6 PIK50181.1 - 0.008 16.9 109.0 1.5 9.6 11.2 7.7 2 1 5 7 7 7 2 Domain of unknown function (DUF4472) TACC_C PF05010.14 PIK50181.1 - 0.085 12.6 101.7 0.66 9.7 12.7 4.0 1 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PQQ_3 PF13570.6 PIK50181.1 - 0.1 13.1 1.9 2.9 8.5 0.1 3.5 3 1 0 3 3 3 0 PQQ-like domain HIP1_clath_bdg PF16515.5 PIK50181.1 - 0.12 13.0 130.0 2.3 8.9 20.1 7.1 1 1 6 7 7 7 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NHL PF01436.21 PIK50181.1 - 0.15 12.1 0.6 62 3.9 0.0 3.9 4 0 0 4 4 4 0 NHL repeat Fez1 PF06818.15 PIK50181.1 - 1.6 9.2 119.4 3.1 8.2 27.2 4.2 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 PIK50181.1 - 2 7.2 111.3 0.48 9.3 26.5 4.2 1 1 4 5 5 5 0 Spc7 kinetochore protein Cep57_MT_bd PF06657.13 PIK50181.1 - 2.3 8.7 82.5 6.4 7.3 5.7 8.6 1 1 10 12 12 12 0 Centrosome microtubule-binding domain of Cep57 TPD52 PF04201.15 PIK50181.1 - 5.2 6.6 104.2 1.7 8.2 9.5 8.4 1 1 7 8 8 8 0 Tumour protein D52 family ZU5 PF00791.20 PIK50182.1 - 4.5e-26 91.1 0.0 3.6e-13 49.7 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain DED PF01335.21 PIK50182.1 - 0.002 18.4 9.4 0.039 14.2 1.2 4.3 4 0 0 4 4 4 2 Death effector domain ZU5 PF00791.20 PIK50183.1 - 4.6e-15 55.8 0.0 8.2e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain RVT_1 PF00078.27 PIK50184.1 - 2e-28 99.4 0.0 4.1e-28 98.4 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) YcgR PF07317.12 PIK50185.1 - 0.075 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Flagellar regulator YcgR ERM PF00769.19 PIK50187.1 - 0.00063 19.6 18.2 0.001 19.0 18.2 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family HIP1_clath_bdg PF16515.5 PIK50187.1 - 0.0059 17.2 20.3 0.012 16.2 20.3 1.6 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 FapA PF03961.13 PIK50187.1 - 0.0084 14.8 8.8 0.0091 14.6 8.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A GAS PF13851.6 PIK50187.1 - 0.0085 15.5 19.8 0.019 14.3 19.8 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 PIK50187.1 - 0.035 13.0 18.0 0.042 12.7 18.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HemX PF04375.14 PIK50187.1 - 0.12 11.6 13.5 0.17 11.2 13.5 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase APG6_N PF17675.1 PIK50187.1 - 0.16 12.5 26.4 0.58 10.7 26.4 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 PIK50187.1 - 0.19 11.8 6.5 0.31 11.1 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF150_C PF17384.2 PIK50187.1 - 0.21 11.8 3.3 6.6 6.9 0.1 2.5 1 1 1 2 2 2 0 RimP C-terminal SH3 domain UPF0242 PF06785.11 PIK50187.1 - 0.3 11.2 16.5 0.49 10.5 16.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_11 PF13086.6 PIK50187.1 - 0.31 10.8 10.2 0.36 10.6 10.2 1.1 1 0 0 1 1 1 0 AAA domain T3SSipB PF16535.5 PIK50187.1 - 0.38 11.2 13.3 9.3 6.7 13.3 2.2 1 1 0 1 1 1 0 Type III cell invasion protein SipB Myb_DNA-bind_3 PF12776.7 PIK50187.1 - 0.57 11.2 6.4 3.6 8.6 0.5 3.0 1 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain DUF4407 PF14362.6 PIK50187.1 - 0.74 9.1 10.6 0.76 9.1 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 PIK50187.1 - 0.92 7.3 9.1 0.89 7.4 9.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliT PF05400.13 PIK50187.1 - 1 10.2 12.6 10 7.0 4.5 3.0 2 1 1 3 3 3 0 Flagellar protein FliT Cep57_MT_bd PF06657.13 PIK50187.1 - 1.1 9.8 14.5 2.7 8.5 5.6 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Seryl_tRNA_N PF02403.22 PIK50187.1 - 2.1 8.6 16.2 3.1 8.1 15.6 1.7 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain AIM5 PF17050.5 PIK50187.1 - 2.1 9.2 6.3 18 6.2 0.5 2.5 1 1 1 2 2 2 0 Altered inheritance of mitochondria 5 DUF5401 PF17380.2 PIK50187.1 - 2.5 6.1 16.6 3.4 5.6 16.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF1542 PF07564.11 PIK50187.1 - 2.6 8.2 15.4 2.1 8.5 1.4 3.6 2 1 3 5 5 5 0 Domain of Unknown Function (DUF1542) JIP_LZII PF16471.5 PIK50187.1 - 2.8 8.2 13.0 12 6.2 1.4 2.5 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II ZapB PF06005.12 PIK50187.1 - 3 8.3 20.0 3.6 8.1 12.8 2.6 1 1 1 2 2 2 0 Cell division protein ZapB Sec20 PF03908.13 PIK50187.1 - 3.4 7.6 8.4 5.3 7.0 3.1 2.8 1 1 1 2 2 2 0 Sec20 DUF3698 PF12479.8 PIK50187.1 - 5.5 7.6 10.4 5.7e+02 1.1 9.9 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3698) Atg14 PF10186.9 PIK50187.1 - 7.1 5.6 14.5 9.8 5.2 14.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4140 PF13600.6 PIK50187.1 - 7.5 7.1 15.1 3 8.3 2.6 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Nnf1 PF03980.14 PIK50187.1 - 9.7 6.6 17.9 1.7 9.1 4.8 2.9 1 1 1 2 2 2 0 Nnf1 ZU5 PF00791.20 PIK50188.1 - 2e-13 50.5 0.0 5.6e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain rve PF00665.26 PIK50189.1 - 2.7e-07 30.8 0.0 4.9e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain ARL6IP6 PF15062.6 PIK50190.1 - 7.1e-15 54.9 0.4 1.2e-14 54.2 0.4 1.4 1 0 0 1 1 1 1 Haemopoietic lineage transmembrane helix PrmA PF06325.13 PIK50191.1 - 8.5e-12 45.1 0.1 1.2e-11 44.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 PIK50191.1 - 2.3e-10 40.3 0.0 3.4e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 PIK50191.1 - 9.7e-09 35.2 0.1 1.2e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK50191.1 - 1.4e-07 32.1 0.1 2.9e-07 31.1 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK50191.1 - 4.8e-07 29.6 0.0 6.2e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 PIK50191.1 - 5.2e-05 23.9 0.0 0.00011 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 PIK50191.1 - 0.002 17.8 2.6 0.0088 15.7 2.5 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 PIK50191.1 - 0.0032 17.1 0.1 0.0047 16.5 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 PIK50191.1 - 0.011 16.4 0.0 0.025 15.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.16 PIK50191.1 - 0.015 14.6 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_16 PF10294.9 PIK50191.1 - 0.041 13.6 0.1 0.097 12.4 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase DNA_methylase PF00145.17 PIK50191.1 - 0.06 12.7 0.2 0.11 11.8 0.1 1.5 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase Methyltransf_4 PF02390.17 PIK50191.1 - 0.076 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_9 PF08003.11 PIK50191.1 - 0.093 11.6 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 PIK50191.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fam20C PF06702.12 PIK50192.1 - 4.3e-61 206.5 0.0 8.1e-61 205.6 0.0 1.4 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK50192.1 - 0.0022 16.9 0.2 0.008 15.1 0.0 1.9 2 0 0 2 2 2 1 FAM198 protein PI3_PI4_kinase PF00454.27 PIK50192.1 - 0.019 14.8 0.6 0.059 13.2 0.6 1.7 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Act-Frag_cataly PF09192.10 PIK50192.1 - 2.6 7.4 5.1 2.9 7.2 0.2 2.7 2 1 0 3 3 3 0 Actin-fragmin kinase, catalytic DUF4449 PF14613.6 PIK50193.1 - 0.093 12.8 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Gal_Lectin PF02140.18 PIK50194.1 - 3.4e-25 88.3 6.3 7.1e-16 58.4 2.3 2.5 2 0 0 2 2 2 2 Galactose binding lectin domain HRM PF02793.22 PIK50194.1 - 0.0062 16.8 1.1 0.0062 16.8 1.1 3.5 2 1 0 2 2 2 1 Hormone receptor domain R3H-assoc PF13902.6 PIK50195.1 - 7.5e-24 84.6 2.2 2.9e-23 82.7 2.2 1.9 1 1 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 PIK50195.1 - 0.01 15.8 0.6 0.043 13.8 0.0 2.4 3 1 0 3 3 3 1 R3H domain VASt PF16016.5 PIK50196.1 - 5.3e-21 75.6 1.6 6.5e-20 72.1 0.0 2.8 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 PIK50196.1 - 3.4e-06 26.9 0.1 8.3e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 GRAM domain eIF2A PF08662.11 PIK50197.1 - 0.063 13.2 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Efg1 PF10153.9 PIK50197.1 - 8.8 6.7 8.4 11 6.4 0.1 2.8 2 1 0 2 2 2 0 rRNA-processing protein Efg1 DCAF15_WD40 PF14939.6 PIK50199.1 - 4.4e-39 134.4 0.0 5.1e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 DDB1-and CUL4-substrate receptor 15, WD repeat Glyoxalase_2 PF12681.7 PIK50200.1 - 0.052 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Glyoxalase-like domain zf-H2C2_2 PF13465.6 PIK50201.1 - 6.6e-25 86.4 57.2 2.8e-08 33.8 2.1 9.7 9 1 0 9 9 9 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK50201.1 - 3.7e-18 64.7 66.1 0.00088 19.9 0.9 8.8 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK50201.1 - 5.3e-10 39.2 68.8 0.00029 21.1 0.1 8.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-met PF12874.7 PIK50201.1 - 0.0039 17.5 0.2 0.0039 17.5 0.2 7.9 8 0 0 8 8 8 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK50201.1 - 0.0075 16.5 0.1 0.0075 16.5 0.1 6.8 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 PIK50201.1 - 0.014 16.1 4.7 0.014 16.1 4.7 4.1 4 1 1 5 5 5 0 TRAF-type zinc finger Bactofilin PF04519.13 PIK50201.1 - 0.015 15.6 0.9 0.015 15.6 0.9 3.4 3 0 0 3 3 3 0 Polymer-forming cytoskeletal zf-C2H2_6 PF13912.6 PIK50201.1 - 0.054 13.5 0.5 0.054 13.5 0.5 8.9 7 2 0 7 7 7 0 C2H2-type zinc finger BRCA-2_OB3 PF09104.10 PIK50201.1 - 0.072 12.7 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 SDA1 PF05285.12 PIK50201.1 - 4.7 6.5 30.2 14 5.0 30.2 1.7 1 0 0 1 1 1 0 SDA1 B277 PF17623.2 PIK50203.1 - 5.3 6.0 6.3 2.8 6.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function NERD PF08378.11 PIK50204.1 - 0.00013 22.3 0.1 0.00048 20.6 0.0 2.0 3 0 0 3 3 3 1 Nuclease-related domain SPOR PF05036.13 PIK50204.1 - 0.024 15.0 0.0 0.051 14.0 0.0 1.4 1 0 0 1 1 1 0 Sporulation related domain NERD PF08378.11 PIK50205.1 - 0.0079 16.6 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 Nuclease-related domain GDI PF00996.18 PIK50205.1 - 0.038 12.5 0.1 0.073 11.6 0.1 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor DUF2075 PF09848.9 PIK50205.1 - 0.058 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) rve PF00665.26 PIK50206.1 - 9.1e-22 77.5 0.0 1.1e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50206.1 - 0.03 14.1 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain PS_Dcarbxylase PF02666.15 PIK50207.1 - 3.8e-64 215.9 0.0 4.5e-64 215.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase PTS_EIIA_1 PF00358.20 PIK50207.1 - 0.064 13.0 0.0 4.2 7.2 0.0 2.2 2 0 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Sulfotransfer_1 PF00685.27 PIK50208.1 - 1.2e-09 38.1 2.9 1e-08 35.0 0.1 2.6 3 0 0 3 3 3 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK50208.1 - 3.1e-07 31.0 0.0 7.4e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK50208.1 - 0.018 15.0 0.8 0.033 14.1 0.5 1.7 1 1 0 1 1 1 0 Sulfotransferase family Spc7 PF08317.11 PIK50208.1 - 0.19 10.5 9.5 0.33 9.8 9.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Dynein_light PF01221.18 PIK50209.1 - 4.5e-43 145.5 2.2 4.9e-43 145.3 2.2 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Sigma70_r2 PF04542.14 PIK50209.1 - 0.079 12.7 0.1 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 Sigma-70 region 2 C2 PF00168.30 PIK50210.1 - 1.5e-52 176.2 0.0 7.3e-25 87.3 0.0 2.1 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 PIK50210.1 - 0.0038 16.8 0.0 4.2 6.9 0.0 2.9 2 1 0 2 2 2 2 CEP76 C2 domain Gti1_Pac2 PF09729.9 PIK50210.1 - 0.14 12.3 0.1 4.1 7.4 0.1 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Amino_oxidase PF01593.24 PIK50211.1 - 4.6e-21 75.6 0.1 3.2e-12 46.5 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK50211.1 - 4.7e-10 39.5 0.1 1e-09 38.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK50211.1 - 4.8e-10 39.6 0.1 2.8e-07 30.5 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK50211.1 - 1.5e-07 30.9 0.1 3.4e-07 29.7 0.3 1.4 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 PIK50211.1 - 1.6e-07 30.4 0.1 0.00018 20.3 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 PIK50211.1 - 5.1e-06 25.9 0.1 8.9e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK50211.1 - 6.6e-06 26.6 0.2 0.00063 20.3 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK50211.1 - 6e-05 22.4 0.1 9.8e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 PIK50211.1 - 6.2e-05 22.5 0.1 9e-05 22.0 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 PIK50211.1 - 0.00013 21.3 0.1 0.0002 20.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain MCRA PF06100.11 PIK50211.1 - 0.0003 19.7 0.0 0.59 8.9 0.0 2.8 3 0 0 3 3 3 2 MCRA family GIDA PF01134.22 PIK50211.1 - 0.00036 19.7 0.1 0.00052 19.2 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 PIK50211.1 - 0.0005 19.4 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 PIK50211.1 - 0.0042 16.4 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 PIK50211.1 - 0.022 14.7 0.0 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding FMO-like PF00743.19 PIK50211.1 - 0.037 12.4 0.0 0.053 11.9 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Ras PF00071.22 PIK50212.1 - 3.7e-35 120.9 0.0 4.6e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK50212.1 - 3.9e-17 62.6 0.0 1.1e-16 61.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK50212.1 - 0.00015 21.3 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK50212.1 - 0.023 14.2 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain ArgoMid PF16487.5 PIK50212.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.6 1 1 0 1 1 1 0 Mid domain of argonaute WBS_methylT PF12589.8 PIK50213.1 - 3.7e-17 62.8 5.0 5.5e-17 62.3 5.0 1.2 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 PIK50213.1 - 7e-11 42.6 0.0 1.3e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK50213.1 - 2.6e-10 40.8 0.0 5.1e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK50213.1 - 7.1e-05 22.7 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK50213.1 - 0.00017 22.3 0.0 0.00068 20.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK50213.1 - 0.0081 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK50213.1 - 0.071 12.4 0.0 0.13 11.5 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase TPMT PF05724.11 PIK50213.1 - 0.079 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) AdoMet_MTase PF07757.13 PIK50213.1 - 0.093 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Syntaxin PF00804.25 PIK50216.1 - 8.5e-64 214.9 18.9 8.5e-64 214.9 18.9 1.4 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 PIK50216.1 - 6.3e-13 48.5 5.4 1.6e-11 44.0 0.9 2.8 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 PIK50216.1 - 1e-11 45.1 8.2 1e-11 45.1 8.2 2.5 1 1 1 2 2 2 1 Syntaxin-like protein DUF3764 PF12594.8 PIK50216.1 - 0.04 14.0 0.4 2.3 8.3 0.0 3.3 4 0 0 4 4 3 0 Protein of unknown function (DUF3764) LPP PF04728.13 PIK50216.1 - 0.084 13.3 1.4 5.7 7.4 0.1 3.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper SKA1 PF07160.12 PIK50216.1 - 0.094 12.6 14.2 0.11 12.3 1.0 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 MCPsignal PF00015.21 PIK50216.1 - 0.14 12.0 11.7 0.82 9.5 0.6 3.1 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Sec34 PF04136.15 PIK50216.1 - 0.19 11.6 15.2 0.13 12.1 1.8 3.3 2 2 1 3 3 3 0 Sec34-like family DUF769 PF05590.11 PIK50216.1 - 0.21 11.0 4.2 0.85 9.0 1.3 2.3 2 1 0 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) Lge1 PF11488.8 PIK50216.1 - 0.36 11.0 0.1 0.36 11.0 0.1 3.1 3 1 0 3 3 3 0 Transcriptional regulatory protein LGE1 Flu_NS2 PF00601.19 PIK50216.1 - 0.42 10.9 7.2 0.16 12.3 2.4 2.6 1 1 1 2 2 2 0 Influenza non-structural protein (NS2) Allexi_40kDa PF05549.11 PIK50216.1 - 0.58 9.6 11.4 0.26 10.7 4.8 2.2 1 1 0 2 2 2 0 Allexivirus 40kDa protein COG2 PF06148.11 PIK50216.1 - 0.78 9.8 14.8 0.79 9.8 1.2 3.4 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 PIK50216.1 - 0.92 10.2 13.4 2.4 8.9 5.2 2.9 2 1 0 2 2 2 0 Initiation control protein YabA DUF948 PF06103.11 PIK50216.1 - 1.4 9.3 8.1 4.4 7.6 2.1 3.5 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 PIK50216.1 - 1.5 8.9 14.0 0.64 10.0 5.7 2.9 2 1 1 3 3 3 0 Laminin Domain II YtxH PF12732.7 PIK50216.1 - 2 9.0 8.8 1.7 9.2 3.3 3.2 2 2 0 2 2 2 0 YtxH-like protein Fez1 PF06818.15 PIK50216.1 - 2.1 8.7 19.5 0.77 10.2 1.0 2.7 2 1 0 2 2 2 0 Fez1 Ead_Ea22 PF13935.6 PIK50216.1 - 2.5 8.7 11.2 3.3e+02 1.9 11.2 3.1 1 1 0 1 1 1 0 Ead/Ea22-like protein NPV_P10 PF05531.12 PIK50216.1 - 2.9 8.4 7.1 4.6 7.8 1.9 3.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF745 PF05335.13 PIK50216.1 - 4.2 7.0 11.4 1.3 8.7 4.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) LOH1CR12 PF10158.9 PIK50216.1 - 6.1 6.9 10.5 4.1 7.4 1.4 2.8 2 1 1 3 3 3 0 Tumour suppressor protein Sugar_tr PF00083.24 PIK50217.1 - 7.8e-32 110.7 30.1 2.8e-30 105.6 30.1 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK50217.1 - 2.5e-29 102.3 43.8 2e-20 73.0 20.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 PIK50217.1 - 0.18 10.2 13.0 0.011 14.2 4.7 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DAGK_prokar PF01219.19 PIK50217.1 - 5.2 7.0 9.4 0.28 11.1 0.1 3.5 3 0 0 3 3 3 0 Prokaryotic diacylglycerol kinase Exo_endo_phos_2 PF14529.6 PIK50218.1 - 0.036 13.9 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Nckap1 PF09735.9 PIK50221.1 - 2.8e-195 651.5 6.6 3.4e-195 651.2 6.6 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Scramblase PF03803.15 PIK50222.1 - 3.6e-66 222.6 0.0 4.4e-66 222.3 0.0 1.1 1 0 0 1 1 1 1 Scramblase Scramblase PF03803.15 PIK50223.1 - 6.9e-43 146.5 0.1 8.5e-43 146.2 0.1 1.1 1 0 0 1 1 1 1 Scramblase RRM_1 PF00076.22 PIK50224.1 - 2.5e-29 100.9 1.8 1.1e-09 37.9 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 PIK50224.1 - 9.1e-08 32.3 0.1 2.2e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Limkain-b1 PF11608.8 PIK50224.1 - 0.00011 22.1 4.1 0.0024 17.9 0.2 3.1 3 0 0 3 3 3 1 Limkain b1 PHM7_cyt PF14703.6 PIK50224.1 - 0.0019 18.5 0.4 9.8 6.4 0.1 3.7 3 1 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 PIK50224.1 - 0.0064 16.6 0.1 0.65 10.1 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif AceK PF06315.11 PIK50224.1 - 0.036 12.6 0.1 0.05 12.1 0.1 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Nup35_RRM_2 PF14605.6 PIK50224.1 - 0.04 13.9 0.4 27 4.9 0.0 3.1 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Beta-Casp PF10996.8 PIK50225.1 - 2e-25 89.2 0.1 2e-24 86.0 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 PIK50225.1 - 9.5e-19 67.1 0.0 2.1e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain UFD1 PF03152.14 PIK50225.1 - 0.0089 15.5 0.0 4.1 6.9 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 WD40 PF00400.32 PIK50226.1 - 1e-37 127.4 15.5 6.2e-06 26.8 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50226.1 - 1.1e-11 44.8 0.9 0.0028 17.9 0.0 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK50226.1 - 0.00082 19.3 1.1 0.05 13.5 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A VPS13 PF16908.5 PIK50227.1 - 5e-60 203.2 10.6 1.7e-58 198.2 5.0 3.6 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 PIK50227.1 - 3.1e-57 193.2 4.5 2.5e-54 183.7 0.1 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13_mid_rpt PF16910.5 PIK50227.1 - 6.5e-51 173.0 13.6 1.1e-42 146.1 1.7 3.5 4 1 0 4 4 4 2 Repeating coiled region of VPS13 SHR-BD PF06650.12 PIK50227.1 - 7.9e-33 114.0 0.0 7.5e-32 110.8 0.0 2.5 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 PIK50227.1 - 1.5e-18 67.0 0.0 5.8e-18 65.1 0.0 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 PIK50227.1 - 4e-05 23.9 0.0 0.00034 20.9 0.0 2.6 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain DUF3484 PF11983.8 PIK50227.1 - 0.014 16.5 0.2 0.13 13.4 0.0 2.5 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch WWE PF02825.20 PIK50227.1 - 0.11 13.1 0.0 0.36 11.4 0.0 1.9 1 0 0 1 1 1 0 WWE domain DUF2076 PF09849.9 PIK50227.1 - 0.12 12.4 0.1 0.31 11.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) WASH_WAHD PF11945.8 PIK50228.1 - 0.015 14.9 0.2 0.027 14.0 0.0 1.4 2 0 0 2 2 2 0 WAHD domain of WASH complex WH2 PF02205.20 PIK50229.1 - 0.00015 21.5 0.4 0.00032 20.4 0.4 1.5 1 0 0 1 1 1 1 WH2 motif SLC35F PF06027.12 PIK50230.1 - 4.1e-88 295.7 21.0 4.7e-88 295.6 21.0 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 PIK50230.1 - 5.3e-10 39.6 29.1 1.7e-06 28.3 19.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 PIK50230.1 - 1.8e-09 37.0 1.8 1.8e-09 37.0 1.8 2.3 1 1 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 PIK50230.1 - 2.1e-05 23.9 15.7 4.5e-05 22.8 15.7 1.5 1 1 0 1 1 1 1 UAA transporter family DMT_6 PF04342.12 PIK50230.1 - 0.031 14.5 0.6 0.031 14.5 0.6 2.9 2 1 0 3 3 3 0 Putative member of DMT superfamily (DUF486) Ras PF00071.22 PIK50231.1 - 8.3e-54 181.5 0.0 9.9e-54 181.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK50231.1 - 1.2e-31 109.4 0.0 1.8e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK50231.1 - 2.4e-13 49.9 0.0 3.1e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK50231.1 - 1.2e-06 28.6 0.0 1.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK50231.1 - 1.9e-05 24.2 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 PIK50231.1 - 0.00062 19.7 0.0 0.31 10.9 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 PIK50231.1 - 0.021 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 PIK50231.1 - 0.055 12.9 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Radical_SAM PF04055.21 PIK50232.1 - 7.1e-09 36.3 0.0 1.2e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Prot_ATP_ID_OB PF16450.5 PIK50232.1 - 0.031 14.2 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain TRAM PF01938.20 PIK50232.1 - 0.052 13.5 0.5 0.55 10.3 0.5 2.4 1 1 0 1 1 1 0 TRAM domain UPF0004 PF00919.20 PIK50233.1 - 2.1e-29 101.5 0.1 3.8e-29 100.6 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 RVT_1 PF00078.27 PIK50233.1 - 3.3e-17 62.8 0.0 5.4e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Radical_SAM PF04055.21 PIK50233.1 - 9.4e-09 35.9 0.0 1.7e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily DUF2529 PF10740.9 PIK50233.1 - 0.032 13.9 0.0 0.097 12.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2529) DUF2152 PF10222.9 PIK50234.1 - 0.033 12.5 0.1 0.1 10.9 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) Glyco_hydro_65m PF03632.15 PIK50235.1 - 2.6e-20 72.7 0.0 8.5e-09 34.7 0.0 3.3 1 1 2 3 3 3 3 Glycosyl hydrolase family 65 central catalytic domain DUF2505 PF10698.9 PIK50235.1 - 0.19 11.8 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) BLOC1S3 PF15753.5 PIK50236.1 - 2.6e-36 125.3 1.3 3.1e-36 125.1 1.3 1.0 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 FHA PF00498.26 PIK50237.1 - 1.8e-16 60.2 0.0 3.4e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK50237.1 - 0.00015 22.0 0.1 0.0052 17.1 0.1 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PB1 PF00564.24 PIK50240.1 - 0.027 14.4 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 PB1 domain TFR_dimer PF04253.15 PIK50241.1 - 6.6e-25 87.6 0.0 1.2e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain LMSTEN PF07988.12 PIK50241.1 - 0.11 11.9 0.4 0.24 10.9 0.4 1.5 1 0 0 1 1 1 0 LMSTEN motif Malic_M PF03949.15 PIK50243.1 - 6.3e-95 317.3 0.1 8e-95 317.0 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 PIK50243.1 - 4.3e-80 267.8 0.0 6.8e-80 267.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain HTH_12 PF08461.10 PIK50243.1 - 0.1 12.6 1.1 0.79 9.7 0.1 2.4 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain NinE PF05322.11 PIK50244.1 - 0.011 15.6 11.5 1.2 9.1 0.2 5.5 2 1 3 5 5 5 0 NINE Protein KLRAQ PF10205.9 PIK50245.1 - 0.027 14.7 4.1 0.027 14.7 4.1 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein ADIP PF11559.8 PIK50245.1 - 0.033 14.3 7.6 0.17 12.0 6.1 2.5 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 PIK50245.1 - 0.05 14.2 7.6 0.63 10.7 3.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Leu_zip PF15294.6 PIK50245.1 - 0.07 12.6 11.9 0.19 11.2 4.4 2.3 1 1 1 2 2 2 0 Leucine zipper HALZ PF02183.18 PIK50245.1 - 0.18 12.0 11.5 5.3 7.3 5.0 3.2 2 1 0 2 2 2 0 Homeobox associated leucine zipper Csm1_N PF18504.1 PIK50245.1 - 0.26 11.7 4.5 0.89 9.9 1.2 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain Cep57_CLD_2 PF14197.6 PIK50245.1 - 0.36 11.0 8.5 3.3 7.9 0.2 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 KIAA1430 PF13879.6 PIK50245.1 - 0.43 11.4 4.6 0.86 10.4 4.6 1.5 1 0 0 1 1 1 0 KIAA1430 homologue SlyX PF04102.12 PIK50245.1 - 0.48 11.1 4.3 20 5.9 1.3 2.7 2 1 0 2 2 2 0 SlyX APC_N_CC PF16689.5 PIK50245.1 - 0.52 10.4 11.2 1.8 8.7 4.1 3.4 2 1 1 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain Cnn_1N PF07989.11 PIK50245.1 - 0.58 10.4 9.6 1.1 9.5 7.2 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 PIK50245.1 - 0.67 10.1 11.3 8 6.6 5.2 3.1 2 1 1 3 3 3 0 bZIP transcription factor PikAIV_N PF18605.1 PIK50245.1 - 0.72 9.5 8.3 0.3 10.7 0.6 3.3 3 0 0 3 3 3 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain bZIP_2 PF07716.15 PIK50245.1 - 1.1 9.3 8.6 3 8.0 0.2 2.9 2 1 1 3 3 3 0 Basic region leucine zipper PRKG1_interact PF15898.5 PIK50245.1 - 1.6 9.7 9.5 4.8 8.1 7.5 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CASP_C PF08172.12 PIK50245.1 - 3.2 7.0 6.6 3.2 7.0 0.3 2.3 1 1 1 2 2 2 0 CASP C terminal Spc24 PF08286.11 PIK50245.1 - 4 7.7 8.9 3.7 7.8 2.0 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 NYD-SP28_assoc PF14775.6 PIK50245.1 - 4.3 7.5 8.0 9.6 6.4 0.1 3.2 2 1 1 3 3 3 0 Sperm tail C-terminal domain Asparaginase_2 PF01112.18 PIK50246.1 - 1.3e-45 155.7 0.6 1.6e-45 155.4 0.6 1.1 1 0 0 1 1 1 1 Asparaginase Sulfotransfer_3 PF13469.6 PIK50247.1 - 8.7e-07 29.5 0.1 3.1e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK50247.1 - 5.8e-06 26.0 0.0 7.2e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Mut7-C PF01927.16 PIK50247.1 - 0.042 14.0 0.2 0.078 13.1 0.1 1.4 1 1 0 1 1 1 0 Mut7-C RNAse domain Sulfotransfer_1 PF00685.27 PIK50248.1 - 5.7e-08 32.6 0.1 1.8e-06 27.6 0.0 2.0 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK50248.1 - 4.2e-07 30.6 0.3 3.2e-06 27.7 0.1 1.9 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK50249.1 - 0.0046 16.5 0.1 1.1 8.7 0.0 2.1 1 1 1 2 2 2 2 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK50250.1 - 2.3e-11 43.7 0.1 3.4e-10 39.8 0.0 2.8 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK50250.1 - 0.00017 22.0 0.2 0.0009 19.7 0.2 2.5 1 1 0 1 1 1 1 Sulfotransferase family V_ATPase_I PF01496.19 PIK50252.1 - 0.078 10.9 1.7 0.085 10.8 1.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5345 PF17280.2 PIK50252.1 - 0.085 12.8 1.5 0.16 12.0 1.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Eaf7 PF07904.13 PIK50252.1 - 0.093 13.1 0.2 0.14 12.6 0.2 1.4 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 DUF2428 PF10350.9 PIK50253.1 - 2.1e-72 243.7 0.9 3.5e-72 242.9 0.2 1.8 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) DUF2428 PF10350.9 PIK50254.1 - 2.8e-05 23.5 0.0 6.1e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) DUF2481 PF10654.9 PIK50254.1 - 0.065 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) Tme5_EGF_like PF09064.10 PIK50254.1 - 0.095 12.6 0.3 0.22 11.4 0.3 1.7 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like NRIP1_repr_1 PF15687.5 PIK50255.1 - 0.13 11.9 0.5 0.28 10.8 0.5 1.5 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 1 DUF5582 PF17819.1 PIK50256.1 - 1.6e-15 57.8 1.3 2.1e-15 57.5 1.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5582) DUF2884 PF11101.8 PIK50256.1 - 0.09 12.3 0.8 1.2 8.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) DUF2951 PF11166.8 PIK50256.1 - 0.098 12.9 0.7 1 9.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) RGS_DHEX PF18148.1 PIK50257.1 - 3.1e-50 168.4 2.2 7.8e-50 167.1 2.2 1.7 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 PIK50257.1 - 1.1e-34 119.2 3.2 1.6e-34 118.7 1.8 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 PIK50257.1 - 1.2e-16 60.5 0.1 1.2e-15 57.3 0.0 2.7 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 PIK50257.1 - 1.6e-07 31.2 0.4 9.5e-07 28.7 0.1 2.3 2 0 0 2 2 2 1 GGL domain RRM_1 PF00076.22 PIK50258.1 - 7.8e-24 83.3 2.2 1.9e-12 46.8 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK50258.1 - 4.3e-12 46.0 0.9 2.1e-06 27.7 0.2 2.7 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 PIK50258.1 - 0.0013 18.7 0.2 2 8.5 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 PIK50258.1 - 0.078 13.2 0.2 11 6.2 0.1 2.6 1 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RL PF17797.1 PIK50258.1 - 0.078 12.9 0.1 6.8 6.7 0.1 2.4 2 0 0 2 2 2 0 RL domain RRM_3 PF08777.11 PIK50258.1 - 0.11 12.5 0.0 0.11 12.5 0.0 2.8 2 1 1 3 3 3 0 RNA binding motif UDPGP PF01704.18 PIK50259.1 - 3.9e-191 635.1 0.4 4.5e-191 634.9 0.4 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DAO_C PF16901.5 PIK50259.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase WD40 PF00400.32 PIK50260.1 - 3.5e-29 100.4 17.0 1.4e-05 25.7 0.0 9.3 10 0 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50260.1 - 1.3e-17 63.8 0.2 0.00026 21.2 0.0 5.0 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK50260.1 - 2.2e-06 27.2 0.8 0.0029 17.0 0.0 3.1 3 1 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 PIK50260.1 - 7.3e-06 25.2 0.2 0.15 11.0 0.0 3.6 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK50260.1 - 0.00034 20.6 0.4 0.0085 16.0 0.0 2.9 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK50260.1 - 0.0014 17.7 0.1 0.21 10.6 0.0 3.0 2 1 1 3 3 3 1 Coatomer WD associated region PSII_BNR PF14870.6 PIK50260.1 - 0.064 12.5 0.1 0.25 10.6 0.0 1.9 2 1 0 2 2 2 0 Photosynthesis system II assembly factor YCF48 Frtz PF11768.8 PIK50260.1 - 0.18 10.1 0.0 0.43 8.8 0.0 1.5 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 PIK50260.1 - 0.22 11.5 1.2 43 4.2 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DDE_Tnp_1_7 PF13843.6 PIK50261.1 - 2.6e-53 181.5 0.2 2.6e-53 181.5 0.2 1.4 2 0 0 2 2 2 1 Transposase IS4 HELP PF03451.14 PIK50261.1 - 9.2e-19 67.1 0.0 2.2e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 PIK50261.1 - 2.6e-05 24.9 1.8 0.011 16.6 0.3 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat DDE_Tnp_1 PF01609.21 PIK50261.1 - 0.0045 16.7 0.6 0.017 14.8 0.4 2.0 1 1 0 1 1 1 1 Transposase DDE domain C1_2 PF03107.16 PIK50261.1 - 0.017 15.4 2.8 0.042 14.2 2.8 1.7 1 0 0 1 1 1 0 C1 domain DUF4845 PF16137.5 PIK50261.1 - 0.031 15.1 1.3 0.12 13.2 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4845) Tnp_zf-ribbon_2 PF13842.6 PIK50261.1 - 0.062 14.1 5.0 0.19 12.6 5.0 1.9 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon C1_1 PF00130.22 PIK50261.1 - 0.27 11.1 3.3 0.71 9.8 3.3 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ig_3 PF13927.6 PIK50262.1 - 5.7e-91 299.2 15.3 9.5e-06 26.1 0.0 18.5 18 0 0 18 18 18 16 Immunoglobulin domain I-set PF07679.16 PIK50262.1 - 2e-66 220.1 0.0 0.00016 21.7 0.0 17.7 18 1 0 18 18 18 13 Immunoglobulin I-set domain ig PF00047.25 PIK50262.1 - 4.2e-51 171.1 7.3 4.8e-05 23.5 0.0 17.8 17 1 0 17 17 17 10 Immunoglobulin domain VWC PF00093.18 PIK50262.1 - 4.7e-43 145.3 251.4 1.1e-10 41.6 14.1 22.2 22 1 1 23 23 14 14 von Willebrand factor type C domain Ig_2 PF13895.6 PIK50262.1 - 1.2e-39 134.5 10.6 0.0071 16.7 0.1 17.3 17 0 0 17 17 17 6 Immunoglobulin domain V-set PF07686.17 PIK50262.1 - 2.2e-37 127.6 13.5 0.0013 18.8 0.0 15.6 16 2 0 16 16 16 11 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK50262.1 - 6.3e-17 60.9 13.2 0.8 9.3 0.0 14.4 16 0 0 16 16 16 4 Immunoglobulin domain Izumo-Ig PF16706.5 PIK50262.1 - 9.9e-11 41.6 0.5 14 5.9 0.0 10.8 14 0 0 14 14 13 1 Izumo-like Immunoglobulin domain TILa PF12714.7 PIK50262.1 - 3.7e-06 26.8 25.5 5.3e-06 26.3 8.1 19.6 21 1 1 22 22 13 6 TILa domain EGF_2 PF07974.13 PIK50262.1 - 0.00013 22.3 48.7 0.0016 18.8 12.3 29.0 33 0 0 33 33 26 19 EGF-like domain EGF PF00008.27 PIK50262.1 - 0.0027 17.9 7.3 0.0027 17.9 7.3 29.4 31 0 0 31 31 25 18 EGF-like domain VWD PF00094.25 PIK50263.1 - 5.9e-38 130.6 0.0 6.6e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain RGM_N PF06535.12 PIK50263.1 - 0.037 14.2 0.1 0.054 13.7 0.1 1.3 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus zf-CCHC PF00098.23 PIK50264.1 - 1.7e-05 24.7 12.0 0.00035 20.5 1.0 2.6 3 0 0 3 3 3 2 Zinc knuckle SCAN PF02023.17 PIK50264.1 - 4.2e-05 23.3 0.3 0.00035 20.3 0.1 2.2 1 1 1 2 2 2 1 SCAN domain zf-CCHC_3 PF13917.6 PIK50264.1 - 0.033 14.2 10.3 0.45 10.5 0.4 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK50264.1 - 0.059 13.1 10.0 0.71 9.7 0.9 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK50264.1 - 0.4 10.5 10.7 0.94 9.4 4.0 2.5 2 0 0 2 2 2 0 Zinc knuckle RNA_pol_N PF01194.17 PIK50264.1 - 0.52 10.7 3.2 12 6.3 0.3 2.7 2 0 0 2 2 2 0 RNA polymerases N / 8 kDa subunit 7tm_1 PF00001.21 PIK50265.1 - 7.3e-23 81.2 16.6 7.3e-23 81.2 16.6 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK50265.1 - 2.3e-10 40.5 18.8 2.3e-10 40.5 18.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK50265.1 - 6.2e-05 22.5 6.0 6.2e-05 22.5 6.0 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_2 PF00002.24 PIK50265.1 - 0.094 12.0 12.4 0.61 9.3 12.4 2.4 1 1 0 1 1 1 0 7 transmembrane receptor (Secretin family) adh_short_C2 PF13561.6 PIK50267.1 - 3.2e-38 131.6 0.1 3.7e-38 131.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK50267.1 - 4.9e-24 84.9 0.2 5.9e-24 84.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Calx-beta PF03160.14 PIK50268.1 - 3.9e-46 155.3 11.7 7.9e-23 80.5 0.4 2.8 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.24 PIK50268.1 - 3.5e-16 59.5 3.0 6.6e-16 58.6 3.0 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.5 PIK50268.1 - 3.3e-10 40.5 0.0 7.8e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain TyrRSs_C PF16714.5 PIK50268.1 - 0.0072 16.1 1.1 1.9 8.3 0.1 2.9 3 0 0 3 3 3 2 Tyrosyl-tRNA synthetase C-terminal domain WRNPLPNID PF15017.6 PIK50269.1 - 0.071 14.0 2.4 0.16 12.9 2.4 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Na_Ca_ex PF01699.24 PIK50270.1 - 1.6e-25 89.8 14.3 2.1e-25 89.5 14.3 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF1118 PF06549.12 PIK50270.1 - 0.15 12.4 1.0 0.26 11.6 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) DPM3 PF08285.11 PIK50270.1 - 2.2 8.5 6.1 6 7.1 6.1 1.7 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Ribosomal_L7Ae PF01248.26 PIK50272.1 - 7.9e-27 92.8 0.2 9.8e-27 92.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 PIK50272.1 - 0.0023 18.0 0.1 0.0024 17.9 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Adenosine_kin PF04008.14 PIK50272.1 - 0.0093 15.8 0.0 0.013 15.3 0.0 1.4 1 1 0 1 1 1 1 Adenosine specific kinase PELOTA_1 PF15608.6 PIK50272.1 - 0.01 15.7 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 PELOTA RNA binding domain RRM_1 PF00076.22 PIK50273.1 - 2e-06 27.5 0.0 4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4402 PF14352.6 PIK50273.1 - 0.35 11.5 2.7 0.81 10.3 1.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4402) Ribosomal_L38e PF01781.18 PIK50275.1 - 2.5e-33 114.0 1.2 2.7e-33 113.9 1.2 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family zinc_ribbon_4 PF13717.6 PIK50276.1 - 0.00024 21.0 1.8 0.011 15.6 0.2 2.3 2 0 0 2 2 2 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 PIK50276.1 - 0.0037 16.6 0.7 1.8 8.1 0.1 2.3 2 0 0 2 2 2 2 zinc-ribbon domain SelR PF01641.18 PIK50276.1 - 0.014 15.5 0.1 0.024 14.7 0.1 1.3 1 1 0 1 1 1 0 SelR domain Yippee-Mis18 PF03226.14 PIK50276.1 - 0.02 15.1 0.6 0.055 13.7 0.6 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-RING_7 PF02591.15 PIK50276.1 - 0.03 14.5 0.1 0.03 14.5 0.1 1.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain zinc_ribbon_5 PF13719.6 PIK50276.1 - 0.036 13.8 2.3 0.31 10.8 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF4107 PF13389.6 PIK50276.1 - 0.047 13.9 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4107) HECT_2 PF09814.9 PIK50276.1 - 0.072 11.9 1.4 0.16 10.8 1.5 1.5 1 1 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF3985 PF13153.6 PIK50277.1 - 0.0015 18.5 2.2 61 3.7 0.0 5.2 2 1 5 7 7 7 0 Protein of unknown function (DUF3985) Phage_FRD3 PF05798.11 PIK50277.1 - 0.003 17.8 7.8 26 5.2 0.2 4.9 1 1 5 6 6 6 6 Bacteriophage FRD3 protein EbsA PF17255.2 PIK50277.1 - 0.01 16.2 3.2 3.8 7.9 0.4 3.0 1 1 2 3 3 3 0 EbsA-like protein DUF2066 PF09839.9 PIK50277.1 - 0.066 12.6 4.1 8.1 5.8 1.1 3.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2066) VEFS-Box PF09733.9 PIK50278.1 - 5.5e-52 175.2 0.5 8.9e-52 174.5 0.5 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein Edc3_linker PF16598.5 PIK50278.1 - 0.43 11.3 4.3 0.31 11.7 1.2 2.4 2 0 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 EF-hand_7 PF13499.6 PIK50279.1 - 2.2e-10 40.8 0.3 3.3e-10 40.2 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK50279.1 - 9.5e-10 37.3 2.8 1.8e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 PIK50279.1 - 1.2e-07 30.9 1.6 0.0079 15.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK50279.1 - 3.2e-07 29.7 3.1 0.00025 20.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 PIK50279.1 - 7.4e-07 28.9 2.1 0.018 14.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair FKBP_C PF00254.28 PIK50279.1 - 0.00022 21.5 0.0 0.00034 20.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SPARC_Ca_bdg PF10591.9 PIK50279.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 PIK50280.1 - 9.4e-10 38.8 0.2 2.2e-09 37.6 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK50280.1 - 3.1e-09 35.7 5.0 1.6e-05 24.1 0.0 3.4 3 0 0 3 3 3 2 EF hand FKBP_C PF00254.28 PIK50280.1 - 1.8e-06 28.2 0.0 3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_6 PF13405.6 PIK50280.1 - 5.1e-06 26.0 6.2 8.7e-05 22.2 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK50280.1 - 0.00012 21.5 4.0 0.0053 16.2 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 PIK50280.1 - 0.00059 19.6 2.5 0.02 14.8 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK50280.1 - 0.023 15.0 0.0 0.055 13.8 0.0 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region F-box-like PF12937.7 PIK50281.1 - 9.5e-09 35.0 0.1 2.2e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like Kelch_4 PF13418.6 PIK50281.1 - 4.1e-08 33.1 0.0 0.0014 18.5 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 PIK50281.1 - 4.4e-06 26.2 0.0 0.0025 17.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 PIK50281.1 - 2e-05 24.5 0.0 6.6e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 PIK50281.1 - 3.3e-05 24.0 0.0 0.0086 16.3 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 PIK50281.1 - 0.00044 20.1 0.0 0.69 10.0 0.0 2.8 2 0 0 2 2 2 2 Kelch motif F-box PF00646.33 PIK50281.1 - 0.00075 19.3 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain Kelch_3 PF13415.6 PIK50281.1 - 0.0041 17.4 0.0 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Pkinase PF00069.25 PIK50282.1 - 8.5e-07 28.6 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50282.1 - 9.8e-05 21.8 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DM PF00751.18 PIK50282.1 - 0.021 14.7 4.5 0.058 13.3 4.5 1.7 1 0 0 1 1 1 0 DM DNA binding domain XET_C PF06955.12 PIK50283.1 - 0.0015 18.3 2.2 8.9 6.2 0.1 3.4 3 0 0 3 3 3 3 Xyloglucan endo-transglycosylase (XET) C-terminus DUF1319 PF07028.11 PIK50283.1 - 0.002 18.4 2.5 1.5 9.1 0.2 3.1 1 1 1 3 3 3 2 Protein of unknown function (DUF1319) Dpoe2NT PF12213.8 PIK50283.1 - 0.14 12.5 1.7 5.8 7.3 0.1 2.8 2 1 0 2 2 2 0 DNA polymerases epsilon N terminal DUF2368 PF10166.9 PIK50283.1 - 0.18 11.4 6.7 3.3 7.3 1.0 2.3 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2368) RVT_1 PF00078.27 PIK50284.1 - 1.1e-29 103.6 0.0 1.3e-29 103.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Apc13p PF05839.11 PIK50287.1 - 0.49 10.6 5.6 0.61 10.3 3.9 2.1 2 1 1 3 3 3 0 Apc13p protein NPL4 PF05021.15 PIK50288.1 - 3.8e-108 361.5 0.0 4.8e-108 361.1 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 PIK50288.1 - 2.9e-61 205.9 0.2 5.6e-61 204.9 0.2 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 PIK50288.1 - 3.1e-19 69.2 0.0 6.1e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-RanBP PF00641.18 PIK50288.1 - 1.9e-06 27.1 1.1 1.9e-06 27.1 1.1 2.1 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others UL21a PF17636.2 PIK50288.1 - 0.037 14.0 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Viral Unique Long protein 21a Glyco_hydro_85 PF03644.13 PIK50289.1 - 4.3e-74 249.7 2.4 9.1e-74 248.6 0.9 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 85 Glyco_hydro_18 PF00704.28 PIK50289.1 - 0.041 13.6 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 C2-set_2 PF08205.12 PIK50290.1 - 0.0012 18.9 0.4 1 9.5 0.3 2.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain YDG PF18657.1 PIK50290.1 - 0.12 12.6 0.2 1.4 9.2 0.0 2.4 2 1 0 2 2 2 0 YDG domain C2-set_2 PF08205.12 PIK50291.1 - 0.019 15.0 0.1 0.095 12.8 0.0 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain RT_RNaseH_2 PF17919.1 PIK50292.1 - 2.8e-26 91.4 0.0 5.1e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50292.1 - 5.5e-22 78.0 0.0 9.4e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK50293.1 - 4.9e-27 93.9 0.0 1.4e-26 92.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK50293.1 - 1.9e-25 89.4 0.1 4e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 PIK50293.1 - 2.1e-24 85.8 0.0 5.5e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50293.1 - 4.7e-10 39.4 0.1 7.4e-09 35.4 0.1 2.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK50293.1 - 3.3e-07 30.0 1.6 4.7e-06 26.3 0.7 2.7 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK50294.1 - 0.0059 16.6 5.0 0.0099 15.9 5.0 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK50294.1 - 0.026 14.8 0.0 0.072 13.4 0.0 1.8 1 0 0 1 1 1 0 Retrotransposon gag protein SQAPI PF16845.5 PIK50294.1 - 0.053 13.9 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor zf-CCHC_5 PF14787.6 PIK50294.1 - 0.073 12.8 1.0 0.15 11.8 1.0 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger SlyX PF04102.12 PIK50294.1 - 2.7 8.7 5.0 15 6.3 0.1 3.0 3 0 0 3 3 3 0 SlyX Peptidase_M24 PF00557.24 PIK50295.1 - 4.3e-24 85.4 0.1 5.1e-24 85.1 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 PIK50296.1 - 1.9e-06 28.6 0.0 3.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain DUF4061 PF13270.6 PIK50298.1 - 3.4e-22 78.6 2.7 3.4e-22 78.6 2.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4061) FAM76 PF16046.5 PIK50298.1 - 0.12 11.7 2.3 0.18 11.1 2.3 1.2 1 0 0 1 1 1 0 FAM76 protein DUF1967 PF09269.11 PIK50298.1 - 0.16 11.9 0.1 0.26 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) PDZ PF00595.24 PIK50299.1 - 5e-13 49.2 0.5 1.1e-12 48.1 0.5 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK50299.1 - 4.3e-06 26.5 0.3 1.2e-05 25.0 0.3 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK50299.1 - 0.0015 18.8 0.1 0.0054 17.0 0.1 2.0 1 1 0 1 1 1 1 PDZ domain DUF4515 PF14988.6 PIK50299.1 - 0.0067 16.3 13.1 0.012 15.4 13.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) KASH_CCD PF14662.6 PIK50299.1 - 0.014 15.2 6.0 0.014 15.2 6.0 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH bZIP_2 PF07716.15 PIK50299.1 - 0.098 12.8 2.7 0.39 10.8 2.7 2.0 1 0 0 1 1 1 0 Basic region leucine zipper Golgin_A5 PF09787.9 PIK50299.1 - 0.2 11.1 8.0 0.3 10.5 8.0 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 NYD-SP28_assoc PF14775.6 PIK50299.1 - 0.91 9.7 3.2 7.9 6.7 1.5 2.5 2 0 0 2 2 2 0 Sperm tail C-terminal domain Fzo_mitofusin PF04799.13 PIK50299.1 - 1.1 8.8 4.8 1.7 8.2 4.8 1.2 1 0 0 1 1 1 0 fzo-like conserved region FAM220 PF15487.6 PIK50299.1 - 3.1 7.4 8.0 5.7 6.5 8.0 1.4 1 0 0 1 1 1 0 FAM220 family DivIC PF04977.15 PIK50299.1 - 4.1 7.2 10.4 2.8 7.8 1.2 2.8 1 1 2 3 3 3 0 Septum formation initiator SNF2_N PF00176.23 PIK50301.1 - 1.1e-08 34.2 0.1 1.7e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Gag_p10 PF02337.17 PIK50301.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Retroviral GAG p10 protein DUF1818 PF08848.11 PIK50301.1 - 0.19 11.8 2.4 18 5.5 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1818) Amidase PF01425.21 PIK50302.1 - 8.9e-15 54.6 0.0 1e-14 54.4 0.0 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 PIK50303.1 - 5.3e-60 203.7 4.9 5.5e-58 197.0 3.3 2.1 1 1 1 2 2 2 2 Amidase MIG-14_Wnt-bd PF06664.12 PIK50304.1 - 2.6e-14 53.2 6.8 3.2e-14 52.9 6.8 1.0 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion DUF2207 PF09972.9 PIK50304.1 - 0.028 13.2 1.0 0.029 13.1 1.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MIG-14_Wnt-bd PF06664.12 PIK50305.1 - 4.4e-57 193.5 17.4 4.4e-57 193.5 17.4 1.8 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion YjcB PF15940.5 PIK50305.1 - 0.26 11.5 5.1 1.7 8.9 0.2 3.0 3 0 0 3 3 3 0 Family of unknown function Herpes_LMP1 PF05297.11 PIK50305.1 - 4.7 6.3 10.3 7.2 5.7 10.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Oscp1 PF10188.9 PIK50306.1 - 4.2e-33 114.9 2.7 1.1e-32 113.6 2.7 1.7 1 0 0 1 1 1 1 Organic solute transport protein 1 Collagen PF01391.18 PIK50307.1 - 3.3e-07 29.9 10.5 9.5e-07 28.5 10.5 1.7 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) CLZ PF16526.5 PIK50307.1 - 0.017 15.5 0.0 0.03 14.7 0.0 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Utp12 PF04003.12 PIK50307.1 - 0.17 12.2 0.0 0.42 10.9 0.0 1.6 2 0 0 2 2 2 0 Dip2/Utp12 Family DUF2730 PF10805.8 PIK50307.1 - 0.24 11.5 0.0 0.52 10.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.11 PIK50307.1 - 0.25 11.8 0.1 0.46 10.9 0.1 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) LIM PF00412.22 PIK50308.1 - 1.2e-26 92.7 25.9 7.2e-15 55.0 4.7 3.1 3 0 0 3 3 3 3 LIM domain zf-dskA_traR PF01258.17 PIK50308.1 - 0.0024 17.8 1.3 0.0024 17.8 1.3 5.4 5 1 1 6 6 6 1 Prokaryotic dksA/traR C4-type zinc finger zf-RanBP PF00641.18 PIK50308.1 - 0.017 14.4 0.2 0.017 14.4 0.2 4.4 5 0 0 5 5 5 0 Zn-finger in Ran binding protein and others zf-RING_6 PF14835.6 PIK50308.1 - 0.1 12.5 0.5 0.1 12.5 0.5 3.4 3 1 0 3 3 3 0 zf-RING of BARD1-type protein Siva PF05458.12 PIK50308.1 - 1.9 8.2 18.3 4.5 6.9 1.2 3.1 1 1 2 3 3 3 0 Cd27 binding protein (Siva) zf-ACC PF17848.1 PIK50308.1 - 9.5 6.4 26.8 38 4.5 0.4 7.2 8 0 0 8 8 8 0 Acetyl-coA carboxylase zinc finger domain LIM PF00412.22 PIK50309.1 - 9.7e-27 93.0 45.3 7.1e-12 45.4 8.5 4.0 4 0 0 4 4 4 3 LIM domain Sulfatase_C PF14707.6 PIK50310.1 - 2.8e-21 76.5 0.1 4.5e-21 75.9 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK50310.1 - 5.4e-17 62.2 0.0 2.1e-16 60.2 0.0 1.8 1 1 1 2 2 2 1 Sulfatase EGF PF00008.27 PIK50311.1 - 0.00093 19.5 4.3 0.00093 19.5 4.3 1.9 1 1 1 2 2 2 1 EGF-like domain hEGF PF12661.7 PIK50311.1 - 0.024 15.3 5.5 0.024 15.3 5.5 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK50311.1 - 0.029 14.7 9.9 0.071 13.5 9.9 1.7 1 0 0 1 1 1 0 EGF-like domain PDZ PF00595.24 PIK50312.1 - 0.04 14.3 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 PIK50312.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 PDZ domain TauD PF02668.16 PIK50313.1 - 1.2e-37 130.2 0.0 1.7e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK50313.1 - 0.0053 17.4 0.1 0.013 16.1 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 PIK50313.1 - 0.017 14.2 0.0 0.031 13.4 0.0 1.4 1 0 0 1 1 1 0 CsiD LIM PF00412.22 PIK50314.1 - 3.7e-30 103.9 45.3 4.1e-16 59.0 5.4 4.1 4 0 0 4 4 4 3 LIM domain DZR PF12773.7 PIK50314.1 - 0.05 13.6 30.0 7.8 6.6 0.7 5.1 2 1 1 3 3 3 0 Double zinc ribbon zf-C4pol PF14260.6 PIK50314.1 - 0.3 11.6 25.5 0.4 11.2 0.0 4.9 3 2 1 4 4 4 0 C4-type zinc-finger of DNA polymerase delta zinc_ribbon_12 PF11331.8 PIK50314.1 - 1.1 9.1 0.0 1.1 9.1 0.0 4.8 3 2 2 5 5 5 0 Probable zinc-ribbon domain Pox_I5 PF04713.12 PIK50315.1 - 0.015 15.3 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus protein I5 PetL PF05115.14 PIK50315.1 - 0.18 11.8 3.3 0.44 10.6 3.3 1.6 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit VI (PetL) Gram_pos_anchor PF00746.21 PIK50315.1 - 0.53 10.3 2.9 0.96 9.5 2.9 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF2783 PF10932.8 PIK50316.1 - 0.085 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) Dynein_IC2 PF11540.8 PIK50317.1 - 3.3e-12 46.1 0.1 6.8e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.32 PIK50317.1 - 8.8e-08 32.7 13.5 0.22 12.4 0.2 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50317.1 - 3.4e-05 24.0 1.0 0.012 15.9 0.1 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PilA4 PF18682.1 PIK50317.1 - 0.08 13.3 0.1 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 Pilin A4 Rtf2 PF04641.12 PIK50317.1 - 0.89 8.9 5.9 1.3 8.3 5.9 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger LRR_8 PF13855.6 PIK50319.1 - 1.5e-11 43.8 23.3 1.5e-08 34.3 8.0 3.3 2 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK50319.1 - 2.1e-09 37.5 32.1 6.1e-06 26.5 3.2 5.0 7 0 0 7 7 7 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK50319.1 - 9.7e-05 21.9 5.3 0.00056 19.4 2.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK50319.1 - 0.0016 18.4 20.9 0.046 13.8 0.1 6.1 6 0 0 6 6 6 2 Leucine Rich repeat Lar_restr_allev PF14354.6 PIK50319.1 - 0.13 12.7 0.4 0.46 10.9 0.1 2.1 2 0 0 2 2 2 0 Restriction alleviation protein Lar LRR_1 PF00560.33 PIK50319.1 - 0.28 11.9 28.3 19 6.3 0.1 7.3 7 0 0 7 7 7 0 Leucine Rich Repeat BAR PF03114.18 PIK50320.1 - 4.2e-27 95.3 6.4 1.2e-26 93.9 3.6 2.0 1 1 1 2 2 2 1 BAR domain SH3_1 PF00018.28 PIK50320.1 - 3.5e-06 26.5 0.1 7.9e-06 25.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK50320.1 - 0.0012 18.7 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK50320.1 - 0.025 14.2 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain DUF4745 PF15923.5 PIK50320.1 - 0.028 14.4 0.1 0.075 13.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) GAS PF13851.6 PIK50320.1 - 0.057 12.8 6.9 0.28 10.5 0.1 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding ApoLp-III PF07464.11 PIK50320.1 - 0.2 11.7 3.2 7.3 6.7 0.1 3.2 3 1 1 4 4 4 0 Apolipophorin-III precursor (apoLp-III) PRP1_N PF06424.12 PIK50320.1 - 0.49 10.8 0.1 0.49 10.8 0.1 3.4 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal ASC PF00858.24 PIK50321.1 - 4e-94 316.1 2.1 5e-94 315.8 2.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Innexin PF00876.18 PIK50321.1 - 0.066 12.5 1.0 0.23 10.7 0.3 1.9 2 0 0 2 2 2 0 Innexin GSHPx PF00255.19 PIK50322.1 - 2.4e-09 36.7 0.1 3.4e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase 7tm_1 PF00001.21 PIK50323.1 - 7.4e-28 97.6 13.6 7.4e-28 97.6 13.6 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK50323.1 - 2e-08 34.2 14.6 2.5e-08 33.9 14.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK50323.1 - 2.6e-06 27.4 4.3 4e-06 26.8 4.3 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 PIK50323.1 - 0.005 16.3 12.1 0.005 16.3 12.1 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK50323.1 - 0.0053 16.2 10.2 0.0072 15.7 10.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SRCR PF00530.18 PIK50324.1 - 1.6e-20 73.5 3.1 2.3e-09 37.6 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50324.1 - 3.1e-07 30.8 1.3 0.0054 17.2 0.3 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK50324.1 - 0.0019 18.7 0.5 0.21 12.1 0.1 2.5 2 1 0 2 2 2 2 Hepsin, SRCR domain SRCR PF00530.18 PIK50325.1 - 2.1e-16 60.3 0.5 3.3e-08 33.9 0.2 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50325.1 - 0.0015 19.0 2.5 0.013 16.0 0.2 2.4 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain RCR PF12273.8 PIK50325.1 - 0.0059 17.3 1.2 0.043 14.5 0.6 2.4 2 1 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.15 PIK50325.1 - 1.6 8.5 6.0 0.28 11.0 1.4 1.9 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Kazal_1 PF00050.21 PIK50326.1 - 5.4e-10 39.1 3.4 5.4e-10 39.1 3.4 2.0 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK50326.1 - 1.4e-09 37.9 6.2 1.8e-09 37.6 4.1 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain MitMem_reg PF13012.6 PIK50327.1 - 2.3e-35 121.4 0.4 4.2e-35 120.6 0.4 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 PIK50327.1 - 4.2e-33 113.8 0.0 1.1e-32 112.4 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CobT PF06213.12 PIK50327.1 - 0.087 12.2 14.7 0.12 11.7 14.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 PIK50327.1 - 0.087 13.3 9.7 0.15 12.5 9.7 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 PIK50327.1 - 0.4 9.6 1.9 0.56 9.1 1.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 PIK50327.1 - 0.62 10.2 12.1 1.3 9.1 12.1 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 PIK50327.1 - 1 8.3 6.3 1.5 7.7 6.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 PIK50327.1 - 1.2 7.5 2.7 1.5 7.2 2.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 PIK50327.1 - 1.3 6.9 8.0 1.7 6.4 8.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 PIK50327.1 - 2.4 7.8 12.9 6.9 6.3 12.9 1.8 1 1 0 1 1 1 0 Connexin O-antigen_lig PF13425.6 PIK50327.1 - 2.5 6.8 7.4 3.4 6.3 7.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 PIK50327.1 - 3.4 6.3 11.3 4.3 6.0 11.3 1.1 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 PIK50327.1 - 5.8 7.0 6.3 10 6.1 6.3 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region SPC12 PF06645.13 PIK50328.1 - 5.6 7.1 9.4 1.2 9.3 4.2 2.5 1 1 1 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) KIND PF16474.5 PIK50329.1 - 5.8e-54 182.9 2.3 6.5e-54 182.8 0.8 1.9 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain FYVE PF01363.21 PIK50329.1 - 2.8e-07 30.5 7.5 2.8e-07 30.5 7.5 2.6 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 PIK50329.1 - 0.0035 17.6 5.8 0.0035 17.6 5.8 3.0 3 0 0 3 3 3 1 FYVE-type zinc finger DUF4874 PF16173.5 PIK50329.1 - 0.14 11.9 0.5 14 5.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) DUF745 PF05335.13 PIK50329.1 - 0.29 10.8 1.3 0.51 10.0 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) PCIF1_WW PF12237.8 PIK50330.1 - 5.1e-62 208.5 0.1 8.5e-62 207.8 0.1 1.4 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain WW PF00397.26 PIK50330.1 - 1.6e-08 34.5 0.5 2.9e-08 33.6 0.5 1.5 1 0 0 1 1 1 1 WW domain tRNA-synt_2d PF01409.20 PIK50331.1 - 2e-46 158.5 0.4 1.9e-29 102.9 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 PIK50331.1 - 4.8e-19 68.6 0.0 9.1e-18 64.5 0.0 2.4 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 PIK50331.1 - 0.035 13.2 0.4 11 4.9 0.6 2.8 2 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) Complex1_LYR PF05347.15 PIK50332.1 - 4.4e-16 58.7 1.6 6e-16 58.2 1.6 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 PIK50332.1 - 1.5e-07 32.0 0.1 1.6e-07 32.0 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Na_H_Exchanger PF00999.21 PIK50333.1 - 8.8e-55 186.0 40.8 2.3e-54 184.6 40.8 1.7 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family TMEM154 PF15102.6 PIK50333.1 - 0.0025 17.7 0.5 0.0057 16.6 0.5 1.6 1 0 0 1 1 1 1 TMEM154 protein family EVI2A PF05399.11 PIK50333.1 - 0.0075 15.9 1.1 0.014 15.0 1.1 1.4 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Mucin PF01456.17 PIK50333.1 - 0.011 15.7 5.7 0.011 15.7 5.7 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3377 PF11857.8 PIK50333.1 - 0.12 12.3 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF418 PF04235.12 PIK50333.1 - 1.1 9.1 7.0 1 9.3 0.3 3.8 3 1 0 4 4 4 0 Protein of unknown function (DUF418) HSP20 PF00011.21 PIK50334.1 - 9.7e-15 54.6 0.0 1.2e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 PIK50334.1 - 0.089 12.4 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 HSP20-like domain found in ArsA TAFH PF07531.14 PIK50335.1 - 1.4e-32 111.6 1.6 2.5e-32 110.8 0.8 1.9 2 0 0 2 2 2 1 NHR1 homology to TAF NHR2 PF08788.11 PIK50335.1 - 2e-22 78.7 0.4 5.5e-22 77.3 0.4 1.7 1 0 0 1 1 1 1 NHR2 domain like zf-MYND PF01753.18 PIK50335.1 - 1.8e-07 31.1 16.7 1.8e-07 31.1 16.7 1.7 2 0 0 2 2 2 1 MYND finger ThiP_synth PF10120.9 PIK50335.1 - 0.045 13.4 0.5 0.085 12.5 0.5 1.4 1 0 0 1 1 1 0 Thiamine-phosphate synthase YtxH PF12732.7 PIK50335.1 - 0.14 12.7 4.3 0.24 12.0 2.3 2.4 2 1 1 3 3 3 0 YtxH-like protein Borrelia_P83 PF05262.11 PIK50335.1 - 0.2 10.1 7.4 0.3 9.5 7.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Apolipoprotein PF01442.18 PIK50335.1 - 1.2 9.0 16.0 9 6.1 16.0 2.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain phage_tail_N PF08400.10 PIK50335.1 - 1.2 9.1 3.4 12 5.9 3.2 2.5 3 0 0 3 3 3 0 Prophage tail fibre N-terminal ATP-synt_B PF00430.18 PIK50335.1 - 1.3 9.1 14.3 2.4 8.3 14.3 1.4 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) HD PF01966.22 PIK50336.1 - 1e-13 51.6 1.3 3.8e-13 49.7 0.1 2.5 3 1 0 3 3 3 1 HD domain SH3_2 PF07653.17 PIK50336.1 - 0.00026 20.6 0.0 0.0007 19.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK50336.1 - 0.00055 19.7 0.1 0.0015 18.4 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain PDEase_I PF00233.19 PIK50336.1 - 0.0063 16.3 1.3 0.025 14.3 0.0 2.4 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Pkinase_Tyr PF07714.17 PIK50337.1 - 4.9e-99 330.8 0.0 5.6e-99 330.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50337.1 - 2.2e-52 178.0 0.0 2.9e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK50337.1 - 0.0038 16.6 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 PIK50337.1 - 0.12 12.0 0.2 0.48 10.0 0.2 2.0 1 1 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.17 PIK50338.1 - 8.8e-59 198.9 0.3 1.2e-38 132.9 0.1 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK50338.1 - 9.6e-23 80.9 0.0 7.2e-12 45.2 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain DUF2199 PF09965.9 PIK50340.1 - 0.0067 16.5 1.9 0.27 11.3 0.0 2.5 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2199) DUF4837 PF16125.5 PIK50340.1 - 0.1 11.6 1.2 7.5 5.5 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4837) DUF2220 PF09983.9 PIK50340.1 - 0.39 10.1 4.8 2.1 7.7 0.8 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) YfhO PF09586.10 PIK50340.1 - 2.8 6.1 10.4 3.2 5.9 10.4 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO MFS_1 PF07690.16 PIK50341.1 - 2.7e-11 43.0 6.9 3.3e-11 42.7 6.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Collagen PF01391.18 PIK50341.1 - 6.6e-10 38.6 2.0 1.2e-08 34.6 2.0 2.2 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) MFS_1 PF07690.16 PIK50342.1 - 2e-09 36.8 6.5 2.5e-09 36.5 6.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK50342.1 - 0.0011 18.0 3.5 0.0013 17.6 3.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter IgGFc_binding PF17517.2 PIK50343.1 - 4.1e-18 65.7 1.7 5.9e-18 65.2 1.7 1.2 1 0 0 1 1 1 1 IgGFc binding protein HYR PF02494.16 PIK50344.1 - 3.7e-29 100.9 16.8 2.3e-17 63.1 0.4 6.1 8 0 0 8 8 8 2 HYR domain IgGFc_binding PF17517.2 PIK50345.1 - 1.2e-41 143.0 5.7 1.2e-41 143.0 5.7 1.7 2 0 0 2 2 2 1 IgGFc binding protein HYR PF02494.16 PIK50345.1 - 4.7e-27 94.1 3.9 8.6e-17 61.3 0.6 2.9 2 0 0 2 2 2 2 HYR domain IgGFc_binding PF17517.2 PIK50346.1 - 0.012 14.9 0.0 0.028 13.7 0.0 1.6 2 0 0 2 2 2 0 IgGFc binding protein DUF5300 PF17224.3 PIK50346.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5300) NPIP PF06409.11 PIK50346.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) HYR PF02494.16 PIK50347.1 - 7.6e-14 51.8 2.4 5.7e-06 26.6 0.3 2.3 2 0 0 2 2 2 2 HYR domain IgGFc_binding PF17517.2 PIK50347.1 - 2.8e-05 23.6 0.4 0.00031 20.1 0.0 2.2 1 1 1 2 2 2 1 IgGFc binding protein ABC2_membrane PF01061.24 PIK50348.1 - 5.9e-47 159.8 28.5 8.5e-47 159.3 28.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 PIK50348.1 - 1.3e-26 93.8 0.2 3.9e-26 92.2 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 PIK50348.1 - 5.9e-05 23.0 0.1 0.048 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 PIK50348.1 - 0.00013 21.2 23.2 0.00051 19.3 23.2 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 PIK50348.1 - 0.00017 21.5 0.1 0.00036 20.5 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 PIK50348.1 - 0.00042 19.8 0.0 0.0012 18.3 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 PIK50348.1 - 0.01 15.9 1.1 0.03 14.4 0.3 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 PIK50348.1 - 0.019 15.5 0.0 0.038 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 PIK50348.1 - 0.042 13.8 0.0 0.08 12.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 PIK50348.1 - 0.045 14.0 0.0 0.52 10.6 0.0 2.4 1 1 0 1 1 1 0 AAA domain AAA_35 PF14516.6 PIK50348.1 - 0.05 12.4 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 PIK50348.1 - 0.073 13.4 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 PIK50348.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK50348.1 - 0.35 10.6 2.8 0.24 11.2 0.2 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF1440 PF07274.12 PIK50348.1 - 1.7 9.0 5.3 4 7.8 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) Ig_3 PF13927.6 PIK50349.1 - 3e-21 75.8 13.5 0.0016 19.0 0.0 6.3 4 2 2 6 6 6 5 Immunoglobulin domain ig PF00047.25 PIK50349.1 - 2.8e-14 53.0 14.4 0.0063 16.7 1.0 6.5 5 1 1 6 6 6 5 Immunoglobulin domain I-set PF07679.16 PIK50349.1 - 3.1e-13 49.6 6.0 0.17 12.0 0.1 6.2 5 1 1 6 6 6 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK50349.1 - 1.9e-08 34.5 14.3 0.022 15.1 0.0 6.1 5 2 1 6 6 6 3 Immunoglobulin domain V-set PF07686.17 PIK50349.1 - 3.1e-08 33.8 14.3 0.41 10.8 0.0 7.2 4 3 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK50349.1 - 1.6e-07 31.6 13.4 0.018 15.4 0.0 6.0 4 3 1 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK50349.1 - 3e-06 27.2 2.3 8.1e-05 22.6 0.2 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK50349.1 - 1.4e-05 25.0 0.7 6.3 6.9 0.0 4.5 3 1 1 4 4 4 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK50349.1 - 1.5e-05 24.5 0.3 1.3 8.7 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain C1-set PF07654.15 PIK50349.1 - 0.0014 19.0 10.7 0.0027 18.1 0.1 4.2 3 1 2 5 5 5 1 Immunoglobulin C1-set domain Pkinase_Tyr PF07714.17 PIK50350.1 - 2.5e-39 135.1 0.0 3.2e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50350.1 - 9.1e-17 61.3 0.0 1.2e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain VP4_helical PF17478.2 PIK50350.1 - 0.054 12.9 0.0 0.097 12.1 0.0 1.4 1 0 0 1 1 1 0 Rotavirus VP4 helical domain V-set PF07686.17 PIK50351.1 - 4.1e-05 23.7 0.0 0.15 12.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK50351.1 - 0.00046 20.3 1.0 0.061 13.5 0.1 3.5 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK50351.1 - 0.00053 20.0 0.3 0.0012 18.9 0.3 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK50351.1 - 0.0043 17.6 4.7 6.1 7.5 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK50351.1 - 0.039 14.0 0.4 4.1 7.5 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin I-set domain PLA2_inh PF02988.15 PIK50351.1 - 0.55 10.9 3.3 6.9 7.4 0.1 3.2 3 0 0 3 3 3 0 Phospholipase A2 inhibitor Ig_3 PF13927.6 PIK50352.1 - 4e-05 24.1 0.4 0.03 14.9 0.3 2.6 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK50352.1 - 7.8e-05 22.8 0.0 0.083 13.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK50352.1 - 0.0014 18.7 0.1 1.6 8.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK50352.1 - 0.0015 18.7 0.3 0.17 12.1 0.1 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK50352.1 - 0.082 13.3 0.1 1.3 9.4 0.1 2.4 2 2 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK50353.1 - 1.1e-05 25.5 0.5 0.044 14.0 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK50353.1 - 1.2e-05 25.4 1.5 0.057 13.6 0.0 3.1 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK50353.1 - 1.5e-05 25.5 5.8 0.23 12.1 0.1 4.5 4 2 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK50353.1 - 3.8e-05 23.7 0.1 9.3e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK50353.1 - 0.00022 21.2 1.3 0.52 10.4 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK50354.1 - 1e-06 28.9 0.0 0.077 13.2 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK50354.1 - 1.4e-05 25.1 0.3 3.8e-05 23.7 0.3 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK50354.1 - 1.6e-05 25.4 2.7 0.15 12.7 0.1 4.2 3 2 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK50354.1 - 1.7e-05 24.9 0.5 0.0095 16.1 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK50354.1 - 0.0011 19.0 0.7 0.26 11.4 0.0 3.6 4 1 0 4 4 4 1 Immunoglobulin I-set domain V-set PF07686.17 PIK50355.1 - 0.0004 20.5 0.1 0.0008 19.6 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF3000 PF11452.8 PIK50355.1 - 0.044 13.3 0.0 0.068 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3000) UCH PF00443.29 PIK50356.1 - 5.7e-51 173.5 0.7 1.1e-50 172.6 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK50356.1 - 4.3e-05 23.3 8.5 0.01 15.4 1.2 3.7 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 PIK50356.1 - 0.00012 21.7 2.1 0.00012 21.7 2.1 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif DUF2271 PF10029.9 PIK50356.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) CLIP PF12032.8 PIK50358.1 - 0.16 12.2 0.2 0.36 11.1 0.2 1.6 1 0 0 1 1 1 0 Regulatory CLIP domain of proteinases Alpha-2-MRAP_N PF06400.11 PIK50358.1 - 0.28 11.2 3.9 0.69 9.9 0.6 2.4 1 1 2 3 3 3 0 Alpha-2-macroglobulin RAP, N-terminal domain CagY_I PF14585.6 PIK50358.1 - 1.7 8.8 10.7 5.9 7.1 0.2 3.1 2 1 1 3 3 3 0 CagY type 1 repeat Ig_3 PF13927.6 PIK50360.1 - 2e-24 86.0 3.0 1.1e-07 32.3 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK50360.1 - 3.8e-19 68.8 2.7 9.1e-05 22.7 0.0 4.1 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK50360.1 - 1.2e-18 67.1 0.4 4.6e-05 23.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK50360.1 - 4e-18 65.3 0.2 1.9e-06 27.9 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_4 PF16680.5 PIK50360.1 - 0.00011 22.4 3.8 3.7 7.9 0.0 4.9 4 1 1 5 5 5 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK50360.1 - 0.00019 21.6 4.8 0.051 13.7 0.2 4.3 5 0 0 5 5 5 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK50360.1 - 0.0028 17.7 0.1 0.97 9.5 0.0 3.2 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 PIK50360.1 - 0.013 15.7 0.3 0.23 11.7 0.0 2.7 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 PepSY_TM_like_2 PF16357.5 PIK50360.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like SGP PF17228.2 PIK50361.1 - 0.024 15.5 0.3 0.028 15.2 0.3 1.1 1 0 0 1 1 1 0 Sulphur globule protein Tristanin_u2 PF16638.5 PIK50361.1 - 0.072 13.9 0.8 0.093 13.6 0.8 1.1 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Ig_3 PF13927.6 PIK50362.1 - 2.9e-12 47.0 9.5 0.0013 19.3 0.1 4.5 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 PIK50362.1 - 3.1e-11 43.5 8.6 0.066 13.6 0.2 4.6 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK50362.1 - 2.2e-09 37.4 7.2 0.04 14.1 0.1 4.4 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK50362.1 - 2.8e-07 30.5 1.2 0.0015 18.5 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin I-set domain V-set PF07686.17 PIK50362.1 - 5.6e-07 29.7 2.4 4.4e-05 23.6 0.0 3.9 3 1 1 4 4 4 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK50362.1 - 0.00011 21.7 0.4 0.051 13.1 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain PRMT5 PF05185.16 PIK50362.1 - 0.0045 16.9 0.1 0.93 9.3 0.0 2.3 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase C2-set_2 PF08205.12 PIK50362.1 - 0.04 14.0 4.1 0.087 12.9 1.3 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK50362.1 - 0.059 13.7 6.5 0.53 10.7 1.0 3.6 3 1 0 3 3 3 0 Immunoglobulin C1-set domain DUF485 PF04341.12 PIK50362.1 - 0.067 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF485 COX2_TM PF02790.15 PIK50362.1 - 0.11 12.7 1.0 0.31 11.2 0.3 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain TMEM154 PF15102.6 PIK50362.1 - 8.8 6.2 8.7 0.38 10.7 1.6 2.3 2 1 0 2 2 2 0 TMEM154 protein family PALP PF00291.25 PIK50363.1 - 6.2e-58 196.5 0.9 8.2e-57 192.8 0.9 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 PIK50363.1 - 9.6e-13 48.4 0.4 8.6e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 CBS domain MFS_1 PF07690.16 PIK50364.1 - 3e-33 115.2 22.4 3.6e-33 115.0 22.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 PIK50364.1 - 0.00043 19.2 1.6 0.00043 19.2 1.6 2.0 2 0 0 2 2 2 1 LacY proton/sugar symporter Nuc_H_symport PF03825.16 PIK50364.1 - 0.00046 19.3 2.3 0.00046 19.3 2.3 2.0 2 1 0 2 2 2 1 Nucleoside H+ symporter Peptidase_A8 PF01252.18 PIK50364.1 - 0.0058 16.9 0.1 0.019 15.2 0.0 1.9 2 0 0 2 2 2 1 Signal peptidase (SPase) II Pkinase_Tyr PF07714.17 PIK50365.1 - 2e-13 50.2 0.4 6.6e-12 45.3 0.1 2.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50365.1 - 5.2e-07 29.3 0.1 1.2e-06 28.1 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain COX2_TM PF02790.15 PIK50365.1 - 0.093 12.9 0.4 0.2 11.9 0.4 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain Spectrin PF00435.21 PIK50366.1 - 4.4e-77 255.3 58.8 1.2e-16 61.0 2.9 9.2 9 0 0 9 9 9 9 Spectrin repeat PilJ PF13675.6 PIK50366.1 - 4.8e-05 23.4 44.3 0.17 11.9 0.5 9.5 5 2 5 12 12 12 4 Type IV pili methyl-accepting chemotaxis transducer N-term ATG16 PF08614.11 PIK50366.1 - 0.0012 19.1 68.1 0.042 14.1 2.8 8.1 4 2 4 8 8 8 4 Autophagy protein 16 (ATG16) THOC7 PF05615.13 PIK50366.1 - 0.015 15.6 1.0 0.015 15.6 1.0 6.7 4 1 3 8 8 8 0 Tho complex subunit 7 Vps51 PF08700.11 PIK50366.1 - 0.026 14.6 9.9 2.4 8.3 0.5 5.1 3 0 0 3 3 3 0 Vps51/Vps67 Sec34 PF04136.15 PIK50366.1 - 0.081 12.8 37.4 1.3 8.9 0.4 9.2 4 2 5 10 10 10 0 Sec34-like family CD24 PF14984.6 PIK50366.1 - 0.2 11.9 0.3 0.41 10.9 0.3 1.5 1 0 0 1 1 1 0 CD24 protein Muted PF14942.6 PIK50366.1 - 1.3 9.4 48.4 1.1 9.6 4.9 8.3 4 2 3 8 8 8 0 Organelle biogenesis, Muted-like protein DASH_Duo1 PF08651.10 PIK50366.1 - 1.8 8.4 9.0 2 8.3 0.1 5.5 5 0 0 5 5 5 0 DASH complex subunit Duo1 FUSC-like PF12805.7 PIK50366.1 - 6.7 5.7 7.6 3.3 6.7 0.9 2.9 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS PI_PP_I PF18363.1 PIK50366.1 - 7.4 6.8 17.3 0.61 10.3 0.8 5.6 6 0 0 6 6 6 0 Phosphoinositide phosphatase insertion domain Spectrin PF00435.21 PIK50367.1 - 3.7e-14 53.1 6.4 6.7e-06 26.5 2.9 4.1 2 1 1 4 4 4 3 Spectrin repeat Sec34 PF04136.15 PIK50367.1 - 2.4e-05 24.3 4.1 0.52 10.2 0.1 3.6 4 0 0 4 4 4 2 Sec34-like family IFT57 PF10498.9 PIK50367.1 - 0.00017 20.7 2.5 0.17 10.9 0.1 3.2 2 1 1 3 3 3 1 Intra-flagellar transport protein 57 Spc7 PF08317.11 PIK50367.1 - 0.0002 20.3 4.4 0.086 11.7 0.3 2.5 1 1 1 2 2 2 2 Spc7 kinetochore protein RmuC PF02646.16 PIK50367.1 - 0.00044 19.5 0.5 0.41 9.7 0.0 2.9 3 0 0 3 3 3 2 RmuC family DUF948 PF06103.11 PIK50367.1 - 0.0034 17.6 1.2 6.9 7.0 0.0 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Alpha-E PF04168.12 PIK50367.1 - 0.0038 17.0 3.3 0.13 12.0 0.1 2.9 1 1 1 3 3 3 1 A predicted alpha-helical domain with a conserved ER motif. Tropomyosin_1 PF12718.7 PIK50367.1 - 0.0041 17.3 4.5 0.57 10.3 1.4 3.0 2 1 1 3 3 3 2 Tropomyosin like Laminin_II PF06009.12 PIK50367.1 - 0.0053 16.8 4.7 0.48 10.4 0.1 3.5 1 1 4 5 5 5 1 Laminin Domain II DUF1664 PF07889.12 PIK50367.1 - 0.006 16.6 5.0 0.52 10.3 0.3 3.9 2 2 2 4 4 4 1 Protein of unknown function (DUF1664) DUF2203 PF09969.9 PIK50367.1 - 0.0068 17.1 2.1 2.9 8.6 0.2 3.3 3 1 1 4 4 4 1 Uncharacterized conserved protein (DUF2203) GvpK PF05121.12 PIK50367.1 - 0.0096 15.9 2.4 0.14 12.2 0.5 3.1 3 1 0 3 3 3 1 Gas vesicle protein K GAS PF13851.6 PIK50367.1 - 0.01 15.2 4.9 0.012 15.0 3.2 2.1 2 1 0 2 2 1 0 Growth-arrest specific micro-tubule binding Noelin-1 PF12308.8 PIK50367.1 - 0.017 15.1 0.5 0.17 11.9 0.1 2.6 2 0 0 2 2 2 0 Neurogenesis glycoprotein NPV_P10 PF05531.12 PIK50367.1 - 0.017 15.5 8.2 3.9 8.0 0.2 4.4 2 1 4 6 6 5 0 Nucleopolyhedrovirus P10 protein SesA PF17107.5 PIK50367.1 - 0.018 15.2 0.8 1.2 9.4 0.1 2.7 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Allexi_40kDa PF05549.11 PIK50367.1 - 0.018 14.5 1.5 0.034 13.6 0.3 2.0 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF2730 PF10805.8 PIK50367.1 - 0.046 13.8 5.6 0.24 11.5 0.1 3.3 2 1 1 3 3 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.11 PIK50367.1 - 0.066 13.6 7.0 25 5.4 0.2 4.6 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 PIK50367.1 - 0.066 13.4 7.8 0.66 10.2 0.1 3.9 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF16 PF01519.16 PIK50367.1 - 0.1 13.1 5.5 4.6 7.8 0.8 2.9 2 1 1 3 3 2 0 Protein of unknown function DUF16 FapA PF03961.13 PIK50367.1 - 0.11 11.1 2.7 0.91 8.0 0.2 2.5 1 1 3 4 4 4 0 Flagellar Assembly Protein A YabA PF06156.13 PIK50367.1 - 0.2 12.3 7.2 1.7 9.4 0.1 3.6 2 1 0 4 4 3 0 Initiation control protein YabA BLOC1_2 PF10046.9 PIK50367.1 - 0.29 11.4 8.8 11 6.3 0.1 4.3 3 1 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PCRF PF03462.18 PIK50367.1 - 0.43 10.4 5.2 2.1 8.2 0.5 2.7 1 1 2 3 3 3 0 PCRF domain Prefoldin PF02996.17 PIK50367.1 - 0.49 10.3 7.1 58 3.6 0.0 4.5 3 1 3 6 6 6 0 Prefoldin subunit BRE1 PF08647.11 PIK50367.1 - 0.6 10.2 6.4 2.8 8.1 0.4 3.6 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase DUF2605 PF10792.9 PIK50367.1 - 0.62 10.0 3.7 3.1 7.8 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2605) DUF4164 PF13747.6 PIK50367.1 - 0.77 10.1 4.2 21 5.5 1.4 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Prefoldin_2 PF01920.20 PIK50367.1 - 0.88 9.6 8.2 22 5.1 0.1 4.3 4 1 0 4 4 4 0 Prefoldin subunit Fib_alpha PF08702.10 PIK50367.1 - 0.93 9.7 7.9 5.1 7.3 0.2 3.3 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family MIS13 PF08202.11 PIK50367.1 - 1.4 8.1 10.2 0.12 11.6 3.6 2.3 1 1 0 2 2 2 0 Mis12-Mtw1 protein family Matrilin_ccoil PF10393.9 PIK50367.1 - 2.8 7.9 4.3 2.1 8.3 0.2 2.9 4 0 0 4 4 2 0 Trimeric coiled-coil oligomerisation domain of matrilin bZIP_1 PF00170.21 PIK50367.1 - 4 7.6 6.7 18 5.5 0.1 3.9 4 0 0 4 4 4 0 bZIP transcription factor Spectrin PF00435.21 PIK50368.1 - 2.1e-16 60.3 17.3 3e-09 37.3 0.9 3.7 2 1 1 4 4 4 2 Spectrin repeat Spc7 PF08317.11 PIK50368.1 - 0.00084 18.3 18.3 0.019 13.9 7.5 2.5 2 1 0 2 2 2 2 Spc7 kinetochore protein Activator-TraM PF11657.8 PIK50368.1 - 0.00085 19.2 11.7 0.0016 18.3 2.6 2.9 2 2 0 2 2 2 1 Transcriptional activator TraM KMP11 PF03037.16 PIK50368.1 - 0.013 16.2 0.8 0.013 16.2 0.8 3.6 2 1 0 3 3 3 0 Kinetoplastid membrane protein 11 Fic PF02661.18 PIK50368.1 - 0.019 15.8 3.2 0.088 13.7 0.1 3.1 1 1 0 2 2 2 0 Fic/DOC family TPR_MLP1_2 PF07926.12 PIK50368.1 - 0.13 12.3 21.6 0.38 10.8 5.7 3.5 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DivIVA PF05103.13 PIK50368.1 - 0.38 10.8 16.6 6.3 6.9 2.7 3.9 2 1 2 4 4 4 0 DivIVA protein DUF724 PF05266.14 PIK50368.1 - 0.41 10.5 15.5 0.44 10.3 2.4 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF724) W2 PF02020.18 PIK50368.1 - 0.55 10.4 7.4 5 7.3 0.7 3.0 3 1 0 3 3 3 0 eIF4-gamma/eIF5/eIF2-epsilon DUF4446 PF14584.6 PIK50368.1 - 0.88 9.5 13.8 7.4 6.5 0.2 3.9 3 1 2 5 5 5 0 Protein of unknown function (DUF4446) DIT1_PvcA PF05141.12 PIK50368.1 - 1 8.8 11.1 0.76 9.2 2.0 2.5 1 1 2 3 3 3 0 Pyoverdine/dityrosine biosynthesis protein Fib_alpha PF08702.10 PIK50368.1 - 1.2 9.3 17.9 1.4 9.1 1.2 3.3 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family ZYG-11_interact PF05884.12 PIK50368.1 - 1.4 8.3 9.5 8.2 5.7 5.1 2.8 2 1 0 2 2 2 0 Interactor of ZYG-11 HIP1_clath_bdg PF16515.5 PIK50368.1 - 2.1 9.0 21.1 2.7 8.7 3.4 3.4 2 2 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ArlS_N PF18719.1 PIK50368.1 - 2.2 8.5 7.9 0.21 11.8 1.1 2.6 2 1 0 2 2 2 0 ArlS sensor domain DUF948 PF06103.11 PIK50368.1 - 6.3 7.1 10.7 17 5.7 0.1 4.2 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 PIK50368.1 - 8.5 6.4 25.2 1.6 8.8 4.7 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Spectrin PF00435.21 PIK50369.1 - 2e-06 28.2 0.2 0.014 15.8 0.0 2.1 2 0 0 2 2 2 2 Spectrin repeat Spectrin PF00435.21 PIK50370.1 - 1.2e-12 48.2 10.1 1.9e-10 41.1 0.3 4.0 3 1 0 3 3 3 2 Spectrin repeat CC2-LZ PF16516.5 PIK50370.1 - 0.014 15.8 1.4 0.16 12.4 0.0 2.8 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator T3SSipB PF16535.5 PIK50370.1 - 0.018 15.5 4.7 0.53 10.8 0.3 3.2 1 1 2 3 3 3 0 Type III cell invasion protein SipB DHR10 PF18595.1 PIK50370.1 - 0.024 14.7 1.9 0.024 14.7 1.9 3.1 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain P53 PF00870.18 PIK50370.1 - 0.053 13.3 0.4 0.52 10.0 0.1 2.2 2 0 0 2 2 2 0 P53 DNA-binding domain Laminin_II PF06009.12 PIK50370.1 - 0.059 13.4 8.5 0.35 10.9 1.1 3.2 1 1 2 3 3 3 0 Laminin Domain II Baculo_PEP_C PF04513.12 PIK50370.1 - 0.068 13.2 7.5 0.17 12.0 1.7 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MAD PF05557.13 PIK50370.1 - 0.076 11.4 10.9 0.024 13.1 4.1 2.1 2 0 0 2 2 2 0 Mitotic checkpoint protein Bap31_Bap29_C PF18035.1 PIK50370.1 - 0.086 12.9 0.9 0.87 9.6 0.0 3.0 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Jnk-SapK_ap_N PF09744.9 PIK50370.1 - 0.24 11.6 10.3 0.23 11.7 2.9 2.7 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 PIK50370.1 - 0.3 11.1 6.7 2 8.5 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) V-SNARE PF05008.15 PIK50370.1 - 0.4 11.1 5.7 0.49 10.8 0.2 3.3 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus TMPIT PF07851.13 PIK50370.1 - 0.68 9.1 5.7 1.8 7.7 0.1 2.2 1 1 0 2 2 2 0 TMPIT-like protein Dynamin_M PF01031.20 PIK50370.1 - 0.8 8.9 5.0 8.6 5.5 0.9 2.5 2 1 0 2 2 2 0 Dynamin central region COG5 PF10392.9 PIK50370.1 - 1.2 9.4 14.2 0.5 10.6 1.7 4.0 3 1 1 4 4 4 0 Golgi transport complex subunit 5 Sec34 PF04136.15 PIK50370.1 - 1.7 8.5 7.7 5.7 6.8 0.3 2.8 2 1 0 2 2 2 0 Sec34-like family Spectrin PF00435.21 PIK50371.1 - 2.3e-66 220.9 98.7 7.5e-07 29.6 0.3 17.8 16 2 0 16 16 16 14 Spectrin repeat Imm52 PF15579.6 PIK50371.1 - 0.15 11.9 0.3 1.2 9.1 0.2 2.4 2 0 0 2 2 2 0 Immunity protein 52 DASH_Duo1 PF08651.10 PIK50371.1 - 0.18 11.6 4.9 9.1 6.1 0.0 5.9 6 1 0 6 6 6 0 DASH complex subunit Duo1 FAA_hydro_N_2 PF18288.1 PIK50371.1 - 0.18 12.3 3.3 1.9 9.0 0.1 4.5 4 0 0 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 DUF2024 PF09630.10 PIK50371.1 - 5.1 7.1 6.2 86 3.1 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF2024) Spectrin PF00435.21 PIK50372.1 - 2.4e-47 159.7 68.4 5.4e-08 33.3 0.9 12.4 12 1 0 12 12 12 9 Spectrin repeat BLOC1_2 PF10046.9 PIK50372.1 - 0.018 15.3 0.4 0.018 15.3 0.4 10.9 12 3 2 14 14 14 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rsa3 PF14615.6 PIK50372.1 - 0.12 11.9 1.3 19 4.9 0.2 3.5 2 0 0 2 2 2 0 Ribosome-assembly protein 3 Spectrin_like PF18373.1 PIK50372.1 - 3.9 7.6 11.9 3.6 7.7 0.1 5.2 5 0 0 5 5 5 0 Spectrin like domain Spectrin PF00435.21 PIK50373.1 - 1.6e-54 182.8 76.6 8.7e-09 35.8 0.2 12.8 10 1 3 13 13 13 8 Spectrin repeat DUF2745 PF10922.8 PIK50373.1 - 0.071 13.4 0.8 0.43 10.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2745) DUF3829 PF12889.7 PIK50373.1 - 0.085 12.3 23.8 0.81 9.1 0.1 7.3 4 3 4 8 8 8 0 Protein of unknown function (DUF3829) Myb_DNA-bind_4 PF13837.6 PIK50373.1 - 0.41 11.0 6.4 9.8 6.6 0.1 4.9 6 1 0 6 6 6 0 Myb/SANT-like DNA-binding domain FAD_SOX PF18371.1 PIK50373.1 - 3.6 8.0 12.1 9.1 6.7 0.3 6.1 6 2 1 7 7 7 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase SLATT_5 PF18160.1 PIK50373.1 - 8.7 5.6 7.6 19 4.5 0.1 3.4 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 Spectrin PF00435.21 PIK50374.1 - 2.2e-07 31.3 10.7 7.7e-06 26.3 3.8 2.9 1 1 2 3 3 3 2 Spectrin repeat DHR10 PF18595.1 PIK50374.1 - 0.00026 21.0 7.3 0.00054 20.0 7.3 1.5 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain Snapin_Pallidin PF14712.6 PIK50374.1 - 0.0071 16.7 0.3 0.0071 16.7 0.3 2.5 2 1 1 3 3 3 1 Snapin/Pallidin YkyA PF10368.9 PIK50374.1 - 0.01 15.5 6.3 0.26 10.9 2.0 2.3 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein DUF724 PF05266.14 PIK50374.1 - 0.016 15.0 1.9 0.023 14.5 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TBK1_CCD1 PF18394.1 PIK50374.1 - 0.018 14.6 0.1 0.018 14.6 0.1 1.7 2 0 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 DUF4482 PF14818.6 PIK50374.1 - 0.036 14.9 5.6 0.057 14.3 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) Prominin PF05478.11 PIK50374.1 - 0.04 11.9 4.4 1.2 7.1 0.2 2.0 1 1 0 2 2 2 0 Prominin EspB PF05802.11 PIK50374.1 - 0.054 13.5 4.6 0.36 10.8 0.7 2.3 2 0 0 2 2 2 0 Enterobacterial EspB protein CorA PF01544.18 PIK50374.1 - 0.088 12.1 6.4 0.024 14.0 1.7 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein OmpH PF03938.14 PIK50374.1 - 0.13 12.6 6.3 0.19 12.1 4.5 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) TssO PF17561.2 PIK50374.1 - 0.16 12.1 0.6 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO CLZ PF16526.5 PIK50374.1 - 0.16 12.3 10.6 0.22 11.9 1.7 3.2 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tweety PF04906.13 PIK50374.1 - 0.19 10.3 1.0 0.47 9.1 0.8 1.6 1 1 1 2 2 2 0 Tweety BLOC1_2 PF10046.9 PIK50374.1 - 0.2 11.9 3.8 0.52 10.6 0.1 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 PIK50374.1 - 0.24 11.5 11.4 0.16 12.1 7.5 2.3 1 1 1 2 2 2 0 Tropomyosin like DUF2203 PF09969.9 PIK50374.1 - 0.29 11.9 4.2 0.52 11.0 3.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Peptidase_C98 PF15499.6 PIK50374.1 - 0.3 10.5 3.0 1.3 8.4 0.1 2.1 1 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Jnk-SapK_ap_N PF09744.9 PIK50374.1 - 0.42 10.8 10.2 0.1 12.8 2.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Syntaxin_2 PF14523.6 PIK50374.1 - 0.51 10.7 11.9 0.56 10.6 2.4 3.1 1 1 2 3 3 3 0 Syntaxin-like protein Seryl_tRNA_N PF02403.22 PIK50374.1 - 0.52 10.6 7.7 0.14 12.4 3.9 2.0 3 1 0 3 3 2 0 Seryl-tRNA synthetase N-terminal domain DUF4200 PF13863.6 PIK50374.1 - 0.57 10.6 6.2 0.25 11.7 0.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Exonuc_VII_L PF02601.15 PIK50374.1 - 0.94 9.0 6.7 1.6 8.2 6.7 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF948 PF06103.11 PIK50374.1 - 0.95 9.8 4.5 35 4.8 0.0 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) FUSC PF04632.12 PIK50374.1 - 1.3 7.5 3.0 1.5 7.3 3.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fib_alpha PF08702.10 PIK50374.1 - 1.7 8.8 9.4 3.5 7.8 1.8 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Sec34 PF04136.15 PIK50374.1 - 1.8 8.4 6.3 2.6 7.9 0.3 2.5 2 1 1 3 3 3 0 Sec34-like family CCDC-167 PF15188.6 PIK50374.1 - 3.3 8.1 7.6 1.3 9.4 1.6 2.8 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 Spectrin PF00435.21 PIK50375.1 - 1.3e-10 41.6 14.9 0.00023 21.6 5.7 4.0 4 0 0 4 4 4 2 Spectrin repeat Spc7 PF08317.11 PIK50375.1 - 8e-06 25.0 9.4 0.0053 15.7 0.9 2.4 1 1 1 2 2 2 2 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 PIK50375.1 - 0.00016 21.8 6.1 0.00016 21.8 6.1 3.8 1 1 3 4 4 4 1 TATA element modulatory factor 1 TATA binding FlxA PF14282.6 PIK50375.1 - 0.00024 21.0 1.4 0.026 14.5 0.7 2.5 2 0 0 2 2 2 1 FlxA-like protein GAS PF13851.6 PIK50375.1 - 0.0033 16.8 10.7 0.0033 16.8 10.7 2.1 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding IFT57 PF10498.9 PIK50375.1 - 0.004 16.2 8.6 0.011 14.8 0.9 2.6 1 1 0 2 2 2 1 Intra-flagellar transport protein 57 AAA_13 PF13166.6 PIK50375.1 - 0.016 13.9 4.0 0.021 13.5 4.0 1.3 1 0 0 1 1 1 0 AAA domain Hrs_helical PF12210.8 PIK50375.1 - 0.017 15.6 8.4 0.32 11.6 0.9 3.4 2 1 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF2913 PF11140.8 PIK50375.1 - 0.02 14.7 4.0 0.28 10.9 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2913) EzrA PF06160.12 PIK50375.1 - 0.03 12.5 10.8 0.014 13.6 2.0 3.2 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA GCN5L1 PF06320.13 PIK50375.1 - 0.034 14.3 4.8 0.15 12.2 0.2 2.5 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) TMEM232 PF15877.5 PIK50375.1 - 0.04 12.9 1.5 0.055 12.5 1.5 1.1 1 0 0 1 1 1 0 Transmembrane protein family 232 BLOC1_2 PF10046.9 PIK50375.1 - 0.056 13.7 6.3 0.24 11.7 0.7 3.4 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAA_hydro_N_2 PF18288.1 PIK50375.1 - 0.066 13.6 2.4 0.2 12.1 0.1 2.6 2 1 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Phage_GP20 PF06810.11 PIK50375.1 - 0.17 11.6 4.7 2.1 8.1 0.8 3.1 1 1 3 4 4 4 0 Phage minor structural protein GP20 DUF4407 PF14362.6 PIK50375.1 - 0.23 10.8 1.7 0.66 9.3 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PilJ PF13675.6 PIK50375.1 - 0.28 11.2 2.5 20 5.2 0.2 2.7 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2203 PF09969.9 PIK50375.1 - 0.29 11.9 6.1 2.1 9.1 0.4 3.2 2 1 1 3 3 2 0 Uncharacterized conserved protein (DUF2203) Laminin_II PF06009.12 PIK50375.1 - 0.37 10.8 8.1 0.27 11.2 2.3 2.9 2 1 1 3 3 2 0 Laminin Domain II TMPIT PF07851.13 PIK50375.1 - 0.43 9.8 8.0 0.15 11.3 3.2 2.1 1 1 1 2 2 2 0 TMPIT-like protein FUSC PF04632.12 PIK50375.1 - 0.47 8.9 1.2 0.69 8.4 1.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3829 PF12889.7 PIK50375.1 - 0.49 9.8 4.8 0.5 9.8 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) AATF-Che1 PF13339.6 PIK50375.1 - 0.49 11.1 9.6 2.3 8.9 9.0 2.2 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF4164 PF13747.6 PIK50375.1 - 0.7 10.2 4.0 3 8.2 1.3 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) DUF1664 PF07889.12 PIK50375.1 - 0.76 9.8 6.3 2.4 8.2 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 PIK50375.1 - 1.7 7.1 5.4 5.4 5.5 5.0 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF3450 PF11932.8 PIK50375.1 - 1.9 7.7 9.5 0.37 10.1 5.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) CC2-LZ PF16516.5 PIK50375.1 - 1.9 8.9 12.6 0.59 10.5 4.8 2.9 2 1 1 3 3 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Sec34 PF04136.15 PIK50375.1 - 2.5 8.0 10.1 12 5.7 6.4 3.0 1 1 2 3 3 3 0 Sec34-like family DivIVA PF05103.13 PIK50375.1 - 2.9 8.0 7.8 3.1 7.9 5.1 2.6 2 1 0 2 2 1 0 DivIVA protein KxDL PF10241.9 PIK50375.1 - 5.2 7.4 12.4 0.14 12.5 0.5 3.6 3 1 1 5 5 4 0 Uncharacterized conserved protein Occludin_ELL PF07303.13 PIK50375.1 - 5.9 7.7 8.6 6.1 7.6 0.8 3.6 1 1 2 3 3 3 0 Occludin homology domain Syntaxin-6_N PF09177.11 PIK50375.1 - 6.5 7.4 12.7 0.83 10.2 2.5 3.3 2 2 1 3 3 3 0 Syntaxin 6, N-terminal FliD_C PF07195.12 PIK50375.1 - 6.7 6.1 8.4 1.8 7.9 0.2 2.6 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus Prefoldin_2 PF01920.20 PIK50375.1 - 6.8 6.7 14.7 2.9 7.9 0.9 4.5 4 2 0 5 5 5 0 Prefoldin subunit Tropomyosin_1 PF12718.7 PIK50375.1 - 7 6.8 12.0 2.4 8.3 4.9 2.7 1 1 1 2 2 2 0 Tropomyosin like AAA_23 PF13476.6 PIK50375.1 - 9.9 6.6 13.5 0.16 12.4 4.6 2.2 2 1 0 2 2 2 0 AAA domain Spectrin PF00435.21 PIK50376.1 - 1.6e-87 288.9 132.7 1.9e-09 37.9 4.2 19.6 17 1 1 18 18 18 15 Spectrin repeat PqqD PF05402.12 PIK50376.1 - 0.59 10.5 8.8 1.4 9.2 1.8 4.7 5 0 0 5 5 5 0 Coenzyme PQQ synthesis protein D (PqqD) MCC-bdg_PDZ PF10506.9 PIK50376.1 - 3.7 7.6 7.3 6.6 6.8 0.3 4.7 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome HSBP1 PF06825.12 PIK50376.1 - 5.3 7.0 25.7 0.89 9.5 0.2 8.7 8 1 0 8 8 8 0 Heat shock factor binding protein 1 Spectrin PF00435.21 PIK50377.1 - 6.8e-16 58.7 22.8 0.00021 21.7 0.0 6.4 5 1 2 7 7 7 4 Spectrin repeat LPP PF04728.13 PIK50377.1 - 0.0087 16.4 3.1 7.4 7.1 0.1 5.0 4 1 0 4 4 4 1 Lipoprotein leucine-zipper T2SSF PF00482.23 PIK50377.1 - 0.012 15.6 0.4 20 5.2 0.1 3.6 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F TMF_TATA_bd PF12325.8 PIK50377.1 - 0.012 15.8 0.1 0.012 15.8 0.1 5.0 5 2 0 5 5 4 0 TATA element modulatory factor 1 TATA binding BAR_3_WASP_bdg PF10456.9 PIK50377.1 - 0.013 15.0 2.3 0.2 11.1 0.0 3.3 2 1 0 3 3 3 0 WASP-binding domain of Sorting nexin protein Mei5_like PF17021.5 PIK50377.1 - 0.016 15.3 4.6 0.032 14.3 2.0 2.8 2 0 0 2 2 2 0 Putative double-strand recombination repair-like RPW8 PF05659.11 PIK50377.1 - 0.016 14.9 5.6 0.23 11.1 0.1 4.3 3 1 0 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF948 PF06103.11 PIK50377.1 - 0.021 15.1 8.5 12 6.2 0.3 5.4 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 PIK50377.1 - 0.1 13.0 13.6 0.49 10.8 0.1 6.3 7 0 0 7 7 6 0 Flagella accessory protein C (FlaC) NYD-SP28_assoc PF14775.6 PIK50377.1 - 0.18 12.0 0.2 0.18 12.0 0.2 3.6 4 0 0 4 4 4 0 Sperm tail C-terminal domain DUF1759 PF03564.15 PIK50377.1 - 0.66 9.9 5.4 0.58 10.1 0.3 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF1759) Rx_N PF18052.1 PIK50377.1 - 1.7 8.9 11.2 1.5 9.2 0.5 4.4 2 1 1 4 4 4 0 Rx N-terminal domain NPV_P10 PF05531.12 PIK50377.1 - 2.6 8.5 17.2 2.7 8.5 0.2 5.9 4 2 2 6 6 6 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 PIK50377.1 - 2.9 8.2 22.4 1 9.7 0.3 5.8 7 1 0 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spectrin PF00435.21 PIK50378.1 - 1.6e-82 272.8 122.0 2.2e-08 34.6 0.8 17.8 16 3 2 18 18 18 15 Spectrin repeat DUF1844 PF08899.11 PIK50378.1 - 0.16 12.3 7.1 4.9 7.5 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1844) Baculo_PEP_C PF04513.12 PIK50378.1 - 5.2 7.1 52.0 1.9 8.5 0.0 10.8 10 1 1 12 12 12 0 Baculovirus polyhedron envelope protein, PEP, C terminus CH PF00307.31 PIK50379.1 - 8.3e-28 96.7 0.5 1.2e-24 86.6 0.2 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK50379.1 - 3.5e-05 23.6 0.1 0.00011 22.0 0.1 1.8 1 1 0 1 1 1 1 CAMSAP CH domain POP1 PF06978.11 PIK50380.1 - 3.8e-34 118.5 18.2 3.8e-22 79.3 6.1 2.3 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 PIK50380.1 - 6e-28 97.0 6.2 4.6e-27 94.2 0.1 2.8 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T PF01571.21 PIK50380.1 - 0.00011 21.7 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain rve PF00665.26 PIK50381.1 - 1.9e-26 92.5 0.0 3.4e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK50381.1 - 3.4e-07 30.3 0.1 6.6e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK50381.1 - 0.099 12.4 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Carn_acyltransf PF00755.20 PIK50382.1 - 4e-85 286.6 0.0 4.6e-85 286.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Nitrophorin PF02087.15 PIK50382.1 - 0.094 12.7 0.4 1.1 9.2 0.0 2.7 3 0 0 3 3 3 0 Nitrophorin EF-hand_6 PF13405.6 PIK50383.1 - 5.2e-06 26.0 4.1 0.00013 21.7 0.4 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 PIK50383.1 - 2.8e-05 24.5 0.2 2.8e-05 24.5 0.2 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK50383.1 - 5.1e-05 22.5 2.2 0.00045 19.6 0.1 3.3 3 0 0 3 3 3 1 EF hand CARM1 PF11531.8 PIK50383.1 - 7.9e-05 22.8 0.1 19 5.5 0.0 6.2 1 1 5 8 8 8 1 Coactivator-associated arginine methyltransferase 1 N terminal Patched PF02460.18 PIK50384.1 - 2.7e-187 624.5 4.3 3.4e-187 624.2 4.3 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK50384.1 - 3.9e-45 153.4 23.8 2.9e-44 150.6 5.6 2.6 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK50384.1 - 1.1e-11 44.3 15.7 4.8e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 PIK50384.1 - 4.3 6.7 26.3 0.3 10.5 10.9 2.5 2 0 0 2 2 2 0 Protein export membrane protein Acyltransferase PF01553.21 PIK50385.1 - 9.4e-08 31.8 0.0 3.6e-07 29.9 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase DAGAT PF03982.13 PIK50385.1 - 5.9e-06 25.4 0.2 1e-05 24.7 0.2 1.4 1 1 0 1 1 1 1 Diacylglycerol acyltransferase AP_endonuc_2 PF01261.24 PIK50386.1 - 2.1e-05 24.1 0.0 7.1e-05 22.3 0.0 1.9 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel F-box-like PF12937.7 PIK50387.1 - 0.004 17.0 0.0 0.012 15.5 0.0 1.9 1 0 0 1 1 1 1 F-box-like I-set PF07679.16 PIK50388.1 - 2e-05 24.6 0.0 0.0001 22.3 0.0 2.1 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK50388.1 - 0.00034 21.1 0.8 0.016 15.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK50388.1 - 0.00044 20.5 0.5 0.17 12.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK50388.1 - 0.01 16.0 1.1 0.033 14.3 0.0 2.3 2 1 1 3 3 3 0 Immunoglobulin V-set domain LEM PF03020.15 PIK50388.1 - 0.093 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 LEM domain Ig_3 PF13927.6 PIK50389.1 - 3.3e-13 50.0 0.3 1e-06 29.2 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK50389.1 - 5.8e-12 45.6 0.1 4.5e-07 30.0 0.1 2.9 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK50389.1 - 2.2e-11 43.9 0.3 7.8e-05 22.9 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK50389.1 - 6.4e-10 39.0 0.1 3.9e-07 30.0 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK50389.1 - 7.4e-09 35.7 0.2 1.5e-07 31.5 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK50389.1 - 0.00076 19.8 0.4 0.062 13.7 0.0 3.2 3 1 1 4 4 4 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK50389.1 - 0.058 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 PIK50389.1 - 0.093 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain A_deaminase PF00962.22 PIK50390.1 - 1.7e-116 389.1 0.0 3.1e-116 388.3 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase DEAD_2 PF06733.15 PIK50392.1 - 9.1e-53 178.5 0.2 9.1e-53 178.5 0.2 2.0 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.6 PIK50392.1 - 1.3e-38 132.9 0.0 7.8e-38 130.3 0.0 2.3 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 PIK50392.1 - 0.0016 18.5 1.8 0.93 9.5 0.6 3.4 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK50392.1 - 0.023 14.4 0.0 4.1 7.1 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF3053 PF11254.8 PIK50392.1 - 5.3 6.6 7.0 0.59 9.7 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) TFIIA PF03153.13 PIK50392.1 - 6 6.7 17.4 0.38 10.7 12.1 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Glyco_transf_29 PF00777.18 PIK50394.1 - 2e-31 109.4 5.3 5e-31 108.1 5.3 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) CRAL_TRIO PF00650.20 PIK50395.1 - 1.2e-21 77.0 0.3 3e-21 75.8 0.0 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain Motile_Sperm PF00635.26 PIK50395.1 - 2.9e-19 68.9 0.6 6.9e-19 67.7 0.1 1.9 2 0 0 2 2 2 1 MSP (Major sperm protein) domain RR_TM4-6 PF06459.12 PIK50395.1 - 2.7 7.8 18.4 4.3 7.1 18.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ank_2 PF12796.7 PIK50396.1 - 1e-72 240.7 2.0 2.7e-15 56.7 0.0 6.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) KAP_NTPase PF07693.14 PIK50396.1 - 1.2e-69 235.0 0.0 2.2e-69 234.2 0.0 1.5 1 0 0 1 1 1 1 KAP family P-loop domain Ank_4 PF13637.6 PIK50396.1 - 1.1e-54 182.2 4.6 4e-09 36.8 0.0 9.1 3 2 7 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 PIK50396.1 - 3.2e-54 179.1 0.4 0.00014 22.1 0.0 12.0 11 1 1 12 12 11 10 Ankyrin repeat Ank_5 PF13857.6 PIK50396.1 - 6.2e-49 163.4 7.8 5.2e-07 29.8 0.1 10.6 2 1 10 12 12 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK50396.1 - 3.7e-46 149.8 0.7 0.0017 18.6 0.0 11.9 11 0 0 11 11 11 9 Ankyrin repeat DUF3995 PF13160.6 PIK50396.1 - 0.034 14.5 4.9 0.024 15.0 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) NQR2_RnfD_RnfE PF03116.15 PIK50396.1 - 0.067 12.6 1.3 0.16 11.4 1.3 1.5 1 0 0 1 1 1 0 NQR2, RnfD, RnfE family Glucos_trans_II PF14264.6 PIK50396.1 - 0.095 12.0 4.9 2.2 7.6 0.8 2.1 2 0 0 2 2 2 0 Glucosyl transferase GtrII NACHT PF05729.12 PIK50396.1 - 0.15 12.0 0.9 7.3 6.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain DUF412 PF04217.13 PIK50396.1 - 0.26 11.2 1.1 0.73 9.7 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF412 MARVEL PF01284.23 PIK50396.1 - 2 8.4 10.3 0.62 10.1 1.1 2.4 2 0 0 2 2 2 0 Membrane-associating domain HlyIII PF03006.20 PIK50396.1 - 5.2 6.7 7.9 12 5.5 1.7 2.2 2 0 0 2 2 2 0 Haemolysin-III related UPF0767 PF15990.5 PIK50397.1 - 8.2e-28 96.4 0.0 9.8e-28 96.1 0.0 1.1 1 0 0 1 1 1 1 UPF0767 family RFXA_RFXANK_bdg PF15289.6 PIK50398.1 - 8.4e-10 39.1 0.7 1.2e-09 38.6 0.7 1.3 1 0 0 1 1 1 1 Regulatory factor X-associated C-terminal binding domain Fip1 PF05182.13 PIK50399.1 - 3e-22 77.8 1.3 5.6e-22 77.0 1.3 1.5 1 0 0 1 1 1 1 Fip1 motif ANAPC15 PF15243.6 PIK50400.1 - 1.4e-23 83.1 12.2 1.4e-23 83.1 12.2 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 15 Astro_capsid_p PF12226.8 PIK50400.1 - 0.00057 19.2 10.3 0.00072 18.8 10.3 1.0 1 0 0 1 1 1 1 Turkey astrovirus capsid protein DUF4746 PF15928.5 PIK50400.1 - 0.0087 15.5 6.0 0.011 15.2 6.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 PIK50400.1 - 0.28 9.2 9.6 0.37 8.8 9.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 PIK50400.1 - 1.4 7.0 12.2 1.6 6.9 12.2 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 PIK50400.1 - 2.1 7.6 10.6 2.5 7.3 10.6 1.0 1 0 0 1 1 1 0 BUD22 DUF4637 PF15470.6 PIK50400.1 - 3.1 7.5 8.0 0.33 10.7 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) FragX_IP PF05994.11 PIK50401.1 - 2.3e-42 145.1 2.4 5.4e-42 143.9 0.1 2.0 2 0 0 2 2 2 2 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 PIK50401.1 - 3.4e-09 36.4 4.8 7.9e-09 35.2 4.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1394) FragX_IP PF05994.11 PIK50402.1 - 1.1e-254 847.5 7.3 1.5e-254 847.0 7.3 1.2 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 PIK50402.1 - 0.00051 19.4 0.3 0.0011 18.3 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) BP28CT PF08146.12 PIK50402.1 - 0.013 15.3 0.4 0.11 12.3 0.0 2.5 2 0 0 2 2 2 0 BP28CT (NUC211) domain WD40 PF00400.32 PIK50403.1 - 5.6e-16 58.6 3.0 0.0088 16.9 0.1 6.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50403.1 - 8e-10 38.9 0.0 0.13 12.6 0.1 4.7 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 PIK50403.1 - 1.2e-07 32.0 0.0 0.43 11.1 0.0 4.3 4 0 0 4 4 4 3 PQQ-like domain BBS2_Mid PF14783.6 PIK50403.1 - 6.1e-05 23.0 0.2 0.0036 17.3 0.1 3.2 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 PIK50403.1 - 8.7e-05 22.0 0.0 0.41 9.9 0.0 2.6 1 1 0 2 2 2 2 WD40-like domain DAGK_cat PF00781.24 PIK50403.1 - 0.015 14.9 2.0 1.9 8.1 0.0 3.7 3 1 1 4 4 4 0 Diacylglycerol kinase catalytic domain PQQ_2 PF13360.6 PIK50403.1 - 0.022 14.3 0.1 0.12 11.9 0.1 1.8 1 1 1 2 2 2 0 PQQ-like domain WD40 PF00400.32 PIK50404.1 - 7.9e-06 26.5 4.1 0.039 14.8 0.1 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK50404.1 - 0.017 14.1 0.0 5.5 5.8 0.0 3.2 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 PIK50405.1 - 4.3e-13 49.5 0.1 1e-12 48.3 0.1 1.7 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.6 PIK50405.1 - 1.7e-10 41.1 0.0 4.2e-09 36.7 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4062) AAA_16 PF13191.6 PIK50405.1 - 1.7e-08 35.0 0.1 7e-08 33.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain APAF1_C PF17908.1 PIK50405.1 - 5.3e-07 29.7 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 APAF-1 helical domain WD40 PF00400.32 PIK50405.1 - 7.1e-05 23.5 0.0 0.0021 18.8 0.0 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat AAA_22 PF13401.6 PIK50405.1 - 8e-05 22.9 0.0 0.00043 20.6 0.0 2.2 2 0 0 2 2 1 1 AAA domain ATPase_2 PF01637.18 PIK50405.1 - 0.00017 21.6 0.1 0.0008 19.4 0.0 2.1 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 PIK50405.1 - 0.0037 16.4 0.0 0.0063 15.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Ge1_WD40 PF16529.5 PIK50405.1 - 0.0049 15.9 0.0 0.0097 14.9 0.0 1.4 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein NB-ARC PF00931.22 PIK50405.1 - 0.005 16.0 0.0 0.0099 15.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Sigma54_activ_2 PF14532.6 PIK50405.1 - 0.0096 16.0 0.1 1 9.5 0.1 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 PIK50405.1 - 0.043 13.4 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK50405.1 - 0.047 14.2 0.0 0.23 12.0 0.0 2.2 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 PIK50405.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein KAP_NTPase PF07693.14 PIK50405.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain Myelin_PLP PF01275.19 PIK50406.1 - 2.5e-37 129.0 12.4 3.3e-37 128.6 12.4 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) PRA1 PF03208.19 PIK50406.1 - 8.5 6.0 11.4 8.1 6.1 8.0 2.2 2 0 0 2 2 2 0 PRA1 family protein Glyco_transf_10 PF00852.19 PIK50407.1 - 2.1e-47 161.1 0.3 3.1e-47 160.6 0.3 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Peptidase_S8 PF00082.22 PIK50408.1 - 1.4e-29 103.3 2.7 1.8e-29 103.0 2.7 1.2 1 1 0 1 1 1 1 Subtilase family Peptidase_M10 PF00413.24 PIK50409.1 - 1.6e-45 154.8 0.1 2.3e-45 154.3 0.1 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 PIK50409.1 - 0.00024 21.6 0.0 0.00059 20.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PG_binding_1 PF01471.18 PIK50409.1 - 0.00025 21.2 0.0 0.00049 20.3 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 PIK50409.1 - 0.019 14.6 0.3 2.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.8 PIK50409.1 - 0.027 14.1 0.1 0.057 13.0 0.1 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 PIK50409.1 - 0.061 12.5 0.2 0.11 11.7 0.2 1.3 1 0 0 1 1 1 0 Met-zincin Tugs PF17840.1 PIK50409.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain WD40 PF00400.32 PIK50410.1 - 4.3e-18 65.3 5.6 2.9e-06 27.9 0.0 6.8 7 0 0 7 7 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50410.1 - 4.2e-16 59.0 0.1 0.0032 17.7 0.0 6.0 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TPR_7 PF13176.6 PIK50410.1 - 0.00046 20.0 2.0 0.53 10.4 0.1 4.3 4 1 0 4 4 3 1 Tetratricopeptide repeat eIF2A PF08662.11 PIK50410.1 - 0.0015 18.5 0.4 0.17 11.7 0.0 3.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK50410.1 - 0.0021 17.2 6.1 3 6.8 0.0 5.1 5 1 0 5 5 5 1 Coatomer WD associated region Ge1_WD40 PF16529.5 PIK50410.1 - 0.0035 16.4 2.3 0.2 10.6 0.0 3.4 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Clathrin PF00637.20 PIK50410.1 - 0.0068 16.3 7.1 1.7 8.5 0.2 4.6 2 1 3 5 5 5 1 Region in Clathrin and VPS FYVE PF01363.21 PIK50410.1 - 0.049 13.8 2.9 1 9.5 0.5 2.8 2 0 0 2 2 2 0 FYVE zinc finger Vps39_1 PF10366.9 PIK50410.1 - 0.1 12.9 1.6 22 5.4 0.1 3.6 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 PIK50410.1 - 0.2 11.8 15.4 1 9.6 0.8 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat YacG PF03884.14 PIK50410.1 - 0.31 10.8 4.4 17 5.2 1.5 2.9 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG ADK_lid PF05191.14 PIK50410.1 - 0.44 10.6 3.1 0.39 10.7 1.0 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-RING_2 PF13639.6 PIK50410.1 - 0.77 10.1 7.9 0.086 13.2 0.9 2.9 2 0 0 2 2 2 0 Ring finger domain TPR_12 PF13424.6 PIK50410.1 - 0.87 9.9 8.0 2.2 8.6 0.3 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 PIK50411.1 - 6.5e-20 71.6 0.0 1e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50411.1 - 5.6e-11 42.2 0.0 9e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK50411.1 - 1.9e-05 24.1 0.0 0.00016 21.1 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK50411.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SMP_LBD PF17047.5 PIK50411.1 - 0.18 11.2 0.0 0.42 10.0 0.0 1.6 1 1 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain Meiosis_expr PF15163.6 PIK50412.1 - 8.7e-37 125.6 3.6 9.9e-37 125.5 3.6 1.0 1 0 0 1 1 1 1 Meiosis-expressed WD40 PF00400.32 PIK50413.1 - 1.5e-46 155.4 34.5 8.1e-07 29.7 0.4 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 PIK50413.1 - 7.1e-12 45.0 6.5 1.8e-11 43.8 5.1 2.4 2 0 0 2 2 2 1 F-box-like Nup160 PF11715.8 PIK50413.1 - 2.6e-10 39.6 18.7 0.019 13.6 0.1 6.1 2 2 4 6 6 6 5 Nucleoporin Nup120/160 F-box PF00646.33 PIK50413.1 - 1.3e-08 34.5 4.7 1.3e-08 34.5 4.7 2.2 2 0 0 2 2 2 1 F-box domain DUF4508 PF14969.6 PIK50413.1 - 0.00039 20.6 0.1 0.0013 18.9 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) WD40_like PF17005.5 PIK50413.1 - 0.0022 17.4 0.7 1.5 8.1 0.2 2.6 1 1 1 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 PIK50413.1 - 0.028 14.0 2.7 0.22 11.1 0.3 2.5 1 1 1 2 2 2 0 PQQ-like domain F-box_4 PF15966.5 PIK50413.1 - 0.066 13.1 3.4 0.067 13.1 0.7 2.5 2 0 0 2 2 2 0 F-box Ras PF00071.22 PIK50414.1 - 1.1e-37 129.1 0.4 4.8e-19 68.5 0.1 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK50414.1 - 6.8e-11 42.4 0.8 9.5e-09 35.5 0.0 2.9 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK50414.1 - 0.0067 16.5 0.0 0.0079 16.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK50414.1 - 0.011 15.6 1.4 1.6 8.6 0.7 2.1 1 1 1 2 2 2 0 RsgA GTPase Arf PF00025.21 PIK50414.1 - 0.038 13.4 0.1 0.79 9.1 0.0 2.1 1 1 1 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 PIK50414.1 - 0.057 12.6 0.2 5.5 6.0 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit RVT_1 PF00078.27 PIK50415.1 - 1.3e-20 73.8 0.0 1.9e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MTH865 PF07747.11 PIK50415.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 MTH865-like family RT_RNaseH_2 PF17919.1 PIK50416.1 - 3.6e-34 116.8 0.1 8.3e-34 115.6 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50416.1 - 5.6e-20 71.6 0.0 1.1e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK50416.1 - 5.6e-17 61.6 1.4 1.3e-16 60.4 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK50416.1 - 9.4e-17 61.3 0.0 2.1e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK50416.1 - 0.011 16.0 0.2 0.025 14.8 0.2 1.7 1 0 0 1 1 1 0 H2C2 zinc finger WD40 PF00400.32 PIK50417.1 - 1e-31 108.4 23.8 6.9e-07 29.9 1.6 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50417.1 - 1.3e-06 28.6 0.3 0.24 11.7 0.1 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK50417.1 - 0.026 13.2 3.9 2.9 6.4 0.2 3.0 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Frtz PF11768.8 PIK50417.1 - 0.15 10.3 0.1 2.1 6.6 0.0 2.0 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz zf-C3Hc3H PF13891.6 PIK50418.1 - 3.7e-14 52.8 6.9 3.7e-14 52.8 6.9 1.9 2 0 0 2 2 2 1 Potential DNA-binding domain TPK_catalytic PF04263.16 PIK50419.1 - 3.4e-31 107.8 0.0 4.6e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 PIK50419.1 - 1.1e-22 79.5 0.1 2.4e-22 78.4 0.1 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain PX PF00787.24 PIK50420.1 - 1.8e-17 63.4 0.6 2.4e-17 62.9 0.6 1.2 1 0 0 1 1 1 1 PX domain Kinesin PF00225.23 PIK50421.1 - 7.3e-109 363.7 1.6 7.3e-109 363.7 1.6 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK50421.1 - 7.1e-28 97.4 0.1 7.1e-28 97.4 0.1 2.9 3 0 0 3 3 3 1 Microtubule binding DUF2118 PF09891.9 PIK50421.1 - 0.062 13.3 0.3 0.062 13.3 0.3 3.6 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2118) DUF1515 PF07439.11 PIK50421.1 - 6.8 6.8 7.7 6.4 6.8 4.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Tropomyosin_1 PF12718.7 PIK50422.1 - 0.0084 16.3 35.8 0.0084 16.3 35.8 9.4 2 2 6 9 9 9 1 Tropomyosin like Mac PF12464.8 PIK50423.1 - 0.84 9.9 5.9 13 6.2 0.0 3.5 3 0 0 3 3 3 0 Maltose acetyltransferase PIP49_C PF12260.8 PIK50424.1 - 4.3e-20 72.1 0.0 8.9e-20 71.1 0.0 1.5 1 1 0 1 1 1 1 Protein-kinase domain of FAM69 gag-asp_proteas PF13975.6 PIK50426.1 - 4.6e-09 36.7 0.0 7e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK50426.1 - 2e-08 34.7 0.1 3.5e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 PIK50426.1 - 1.5e-06 28.0 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK50426.1 - 0.0068 16.7 0.1 0.039 14.2 0.1 2.0 1 1 0 1 1 1 1 Retroviral aspartyl protease RT_RNaseH_2 PF17919.1 PIK50427.1 - 1.8e-37 127.4 0.1 3.5e-37 126.4 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50427.1 - 9.8e-34 115.8 0.1 1.9e-33 114.9 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50427.1 - 2.8e-31 108.8 0.0 4.4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK50427.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase rve PF00665.26 PIK50428.1 - 8.8e-23 80.8 0.0 1.6e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50428.1 - 0.0059 16.4 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK50428.1 - 0.024 15.1 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RVT_1 PF00078.27 PIK50429.1 - 3.8e-27 95.3 0.0 5.6e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4722 PF15849.5 PIK50429.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) WDCP PF15390.6 PIK50430.1 - 0.0007 18.1 9.9 0.00087 17.8 9.9 1.0 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family FliD_C PF07195.12 PIK50430.1 - 0.01 15.3 1.9 0.012 15.1 0.5 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CLZ PF16526.5 PIK50430.1 - 0.083 13.3 0.9 0.083 13.3 0.9 3.0 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ABC_tran_CTD PF16326.5 PIK50430.1 - 0.12 12.6 5.7 11 6.4 0.0 3.2 3 1 0 3 3 3 0 ABC transporter C-terminal domain DUF2735 PF10931.8 PIK50430.1 - 0.13 13.0 0.1 0.42 11.3 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2735) Spc24 PF08286.11 PIK50430.1 - 0.18 12.1 0.2 0.18 12.1 0.2 2.3 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 DUF3138 PF11336.8 PIK50430.1 - 0.18 10.4 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HisKA PF00512.25 PIK50430.1 - 0.43 10.6 4.8 7.4 6.7 1.8 2.7 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain GrpE PF01025.19 PIK50430.1 - 0.45 10.2 5.5 0.36 10.5 2.6 2.1 2 1 1 3 3 3 0 GrpE FlxA PF14282.6 PIK50430.1 - 0.47 10.5 10.7 0.097 12.7 3.0 2.6 1 1 1 2 2 2 0 FlxA-like protein CCDC-167 PF15188.6 PIK50430.1 - 0.52 10.7 8.8 0.3 11.4 1.8 2.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Phage_GPO PF05929.11 PIK50430.1 - 0.66 9.5 8.5 0.056 13.1 2.1 1.9 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase NPV_P10 PF05531.12 PIK50430.1 - 0.88 10.1 5.8 0.42 11.1 1.7 2.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein FUSC PF04632.12 PIK50430.1 - 1.2 7.5 4.1 1.5 7.2 4.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Noelin-1 PF12308.8 PIK50430.1 - 1.5 8.8 8.4 0.33 11.0 1.9 2.8 2 1 1 3 3 3 0 Neurogenesis glycoprotein Exonuc_VII_L PF02601.15 PIK50430.1 - 8.6 5.8 13.4 55 3.2 12.4 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit RVT_1 PF00078.27 PIK50431.1 - 2.9e-36 125.1 0.1 3.4e-36 124.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PNMA PF14893.6 PIK50432.1 - 3.7e-09 36.4 0.1 4.2e-09 36.2 0.1 1.0 1 0 0 1 1 1 1 PNMA CdiA_C PF18451.1 PIK50432.1 - 0.022 15.0 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 Contact-dependent growth inhibition CdiA C-terminal domain PqqD PF05402.12 PIK50432.1 - 0.089 13.1 0.0 0.46 10.8 0.0 2.1 1 1 2 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) L_HMGIC_fpl PF10242.9 PIK50433.1 - 3.6e-15 56.6 0.8 4e-15 56.5 0.8 1.1 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein L_HMGIC_fpl PF10242.9 PIK50434.1 - 3.5e-13 50.1 0.7 3.8e-13 50.0 0.7 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein SSF PF00474.17 PIK50435.1 - 0.0054 15.6 0.5 0.0054 15.6 0.5 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family SSF PF00474.17 PIK50436.1 - 1.1e-15 57.5 9.6 1e-11 44.4 2.2 2.0 2 0 0 2 2 2 2 Sodium:solute symporter family zf-H2C2_2 PF13465.6 PIK50437.1 - 6.1e-39 130.7 58.3 1.8e-08 34.4 1.4 8.5 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK50437.1 - 1.4e-31 107.2 58.6 5e-06 26.7 3.0 7.8 8 0 0 8 8 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK50437.1 - 5.3e-28 95.3 55.9 0.00015 22.3 1.3 8.5 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK50437.1 - 3.9e-19 68.4 32.5 0.00047 20.4 0.2 8.5 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding NPL PF17800.1 PIK50437.1 - 5.4e-14 52.6 0.9 2.3e-13 50.6 0.1 2.3 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-met PF12874.7 PIK50437.1 - 3.6e-11 43.1 38.4 0.00092 19.5 0.5 7.6 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK50437.1 - 2.1e-09 37.1 49.4 0.024 14.7 4.1 8.6 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK50437.1 - 1.4e-06 27.9 31.5 0.00033 20.4 0.2 7.1 7 0 0 7 7 7 3 zinc-finger C2H2-type BolA PF01722.18 PIK50437.1 - 9.6e-06 25.8 6.9 3 8.2 0.1 6.5 2 2 3 5 5 5 1 BolA-like protein zf-C2HE PF16278.5 PIK50437.1 - 5.4e-05 23.6 43.1 0.0016 18.8 1.7 7.4 2 2 5 7 7 7 4 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 PIK50437.1 - 0.0019 18.5 38.0 0.26 11.6 0.9 7.7 1 1 5 7 7 7 3 C2H2 type zinc-finger (2 copies) Fil_haemagg_2 PF13332.6 PIK50437.1 - 0.012 15.8 1.9 0.024 14.8 1.9 1.4 1 0 0 1 1 1 0 Hemagglutinin repeat zf-AN1 PF01428.16 PIK50437.1 - 0.55 10.4 35.0 3.5 7.9 0.8 7.3 5 2 1 6 6 6 0 AN1-like Zinc finger zf-CHY PF05495.12 PIK50437.1 - 0.79 10.3 40.4 0.084 13.4 2.5 4.7 1 1 3 4 4 4 0 CHY zinc finger RNA_pol_N PF01194.17 PIK50437.1 - 1 9.7 6.0 1.1e+02 3.2 4.8 3.6 2 1 0 2 2 2 0 RNA polymerases N / 8 kDa subunit NADH-G_4Fe-4S_3 PF10588.9 PIK50437.1 - 1.4 8.5 12.1 6.3 6.4 0.3 4.9 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region ROS_MUCR PF05443.11 PIK50437.1 - 1.4 9.0 6.8 3.3 7.8 1.3 3.0 2 1 1 3 3 3 0 ROS/MUCR transcriptional regulator protein FdhD-NarQ PF02634.15 PIK50437.1 - 1.8 8.2 6.3 4.3 6.9 2.1 2.6 2 1 0 2 2 2 0 FdhD/NarQ family zinc_ribbon_15 PF17032.5 PIK50437.1 - 4.4 8.1 30.8 0.49 11.2 3.6 4.9 1 1 4 6 6 6 0 zinc-ribbon family zf-ribbon_3 PF13248.6 PIK50437.1 - 7.6 6.1 8.0 18 4.9 0.4 3.9 3 0 0 3 3 3 0 zinc-ribbon domain Pkinase PF00069.25 PIK50438.1 - 5.2e-39 134.2 0.0 7.3e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50438.1 - 1e-26 93.8 0.0 5.6e-24 84.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK50438.1 - 0.0038 16.6 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Dimer_Tnp_hAT PF05699.14 PIK50439.1 - 0.019 14.7 0.1 0.04 13.7 0.1 1.6 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region tRNA_m1G_MT PF01746.21 PIK50439.1 - 0.024 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase Como_SCP PF02248.16 PIK50439.1 - 0.085 12.4 0.0 10 5.7 0.0 2.2 2 0 0 2 2 2 0 Small coat protein Phage_integrase PF00589.22 PIK50441.1 - 0.00013 21.9 0.1 0.04 13.7 0.0 2.5 1 1 1 2 2 2 2 Phage integrase family Integrase_1 PF12835.7 PIK50441.1 - 0.066 13.3 0.2 0.18 11.9 0.1 1.7 2 0 0 2 2 2 0 Integrase EGF_CA PF07645.15 PIK50442.1 - 8.5e-06 25.9 4.0 8.5e-06 25.9 4.0 7.7 4 2 3 7 7 7 1 Calcium-binding EGF domain cEGF PF12662.7 PIK50442.1 - 0.0056 16.6 1.1 0.0056 16.6 1.1 7.6 8 0 0 8 8 8 2 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK50442.1 - 0.0067 16.6 8.5 0.0067 16.6 8.5 8.0 6 1 1 7 7 7 4 EGF domain EGF_2 PF07974.13 PIK50442.1 - 0.011 16.1 10.4 0.011 16.1 10.4 7.6 7 1 0 7 7 7 0 EGF-like domain VWD PF00094.25 PIK50443.1 - 1.5e-06 28.6 0.0 7.3e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type D domain AMOP PF03782.17 PIK50443.1 - 0.042 13.9 5.0 0.068 13.3 5.0 1.3 1 0 0 1 1 1 0 AMOP domain EGF_CA PF07645.15 PIK50444.1 - 1.9e-40 136.8 162.6 9.3e-12 45.0 4.0 11.7 10 1 1 11 11 11 9 Calcium-binding EGF domain cEGF PF12662.7 PIK50444.1 - 2.1e-17 62.7 111.4 1.2e-05 25.2 2.8 13.5 13 1 0 13 13 13 8 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK50444.1 - 8.3e-12 45.1 34.0 6.4e-08 32.7 2.7 12.6 12 1 0 12 12 12 6 EGF domain EGF PF00008.27 PIK50444.1 - 1.9e-06 28.0 38.0 0.00012 22.3 9.0 13.0 12 2 0 12 12 12 5 EGF-like domain EGF_MSP1_1 PF12946.7 PIK50444.1 - 0.0021 18.1 16.2 0.004 17.2 2.8 11.7 11 1 0 11 11 11 4 MSP1 EGF domain 1 hEGF PF12661.7 PIK50444.1 - 0.012 16.2 6.7 0.012 16.2 6.7 12.4 11 3 1 12 12 12 0 Human growth factor-like EGF AAA_6 PF12774.7 PIK50446.1 - 6.8e-158 524.8 0.3 4.4e-157 522.2 0.0 2.6 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region Dynein_C PF18199.1 PIK50446.1 - 7.1e-106 353.9 0.0 1.3e-101 339.9 0.0 3.3 3 0 0 3 3 3 2 Dynein heavy chain C-terminal domain DHC_N2 PF08393.13 PIK50446.1 - 1.8e-105 353.3 3.7 1.8e-105 353.3 3.7 4.2 3 2 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK50446.1 - 3.4e-104 347.8 0.1 1.3e-103 345.9 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK50446.1 - 2.1e-94 314.8 0.6 4.6e-93 310.4 1.4 2.7 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 PIK50446.1 - 3.2e-76 254.9 0.0 8.3e-73 243.7 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 PIK50446.1 - 6.3e-59 198.5 0.0 1.8e-58 197.0 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK50446.1 - 8.3e-43 145.3 0.0 3.1e-41 140.2 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 PIK50446.1 - 1.2e-23 83.7 17.4 1.7e-12 47.0 1.8 2.6 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 PIK50446.1 - 6.1e-21 74.9 7.8 8.3e-21 74.4 3.8 3.4 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 PIK50446.1 - 2.4e-20 72.6 0.1 8.6e-20 70.8 0.1 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 PIK50446.1 - 4.6e-19 68.8 0.2 0.0012 18.9 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 PIK50446.1 - 3.8e-08 34.0 0.1 0.079 13.5 0.0 4.3 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 PIK50446.1 - 1.1e-06 29.1 0.5 0.66 10.4 0.0 4.4 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK50446.1 - 0.00027 21.3 0.0 0.23 11.9 0.0 3.2 2 0 0 2 2 2 1 RNA helicase Sigma54_activat PF00158.26 PIK50446.1 - 0.00096 18.9 1.7 0.075 12.7 0.0 3.9 5 0 0 5 5 5 1 Sigma-54 interaction domain AAA_16 PF13191.6 PIK50446.1 - 0.0013 19.1 12.8 0.28 11.5 0.0 5.6 5 1 1 6 6 4 2 AAA ATPase domain T2SSE PF00437.20 PIK50446.1 - 0.0016 17.5 0.1 0.045 12.8 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_22 PF13401.6 PIK50446.1 - 0.0025 18.1 4.8 0.56 10.5 0.0 4.7 4 1 0 4 4 4 1 AAA domain TrwB_AAD_bind PF10412.9 PIK50446.1 - 0.035 13.0 0.1 0.4 9.5 0.0 2.7 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 PIK50446.1 - 0.037 14.0 0.9 1.4 8.9 0.0 3.0 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 PIK50446.1 - 0.064 13.0 1.6 4.9 6.8 0.1 3.4 3 0 0 3 3 3 0 AAA domain DUF5082 PF16888.5 PIK50446.1 - 0.12 12.7 4.5 0.4 11.0 1.7 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) NACHT PF05729.12 PIK50446.1 - 0.12 12.3 0.2 9.2 6.2 0.0 3.3 2 0 0 2 2 2 0 NACHT domain CbiA PF01656.23 PIK50446.1 - 0.12 12.4 0.7 24 5.0 0.0 3.5 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Mg_chelatase PF01078.21 PIK50446.1 - 0.18 11.2 0.7 1.2 8.5 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 PIK50446.1 - 0.21 11.4 0.3 3.2 7.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.6 PIK50446.1 - 0.24 11.0 2.5 37 3.8 0.1 4.0 3 1 1 4 4 4 0 AAA domain DUF87 PF01935.17 PIK50446.1 - 6.5 6.8 10.9 0.42 10.7 0.2 4.0 3 0 0 3 3 3 0 Helicase HerA, central domain FlxA PF14282.6 PIK50446.1 - 6.6 6.8 12.9 2 8.4 5.5 3.0 2 0 0 2 2 2 0 FlxA-like protein Tctex-1 PF03645.13 PIK50447.1 - 4.8e-21 74.9 0.0 6e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family THUMP PF02926.17 PIK50447.1 - 0.0014 18.7 0.0 0.0019 18.3 0.0 1.2 1 0 0 1 1 1 1 THUMP domain TIR-like PF10137.9 PIK50447.1 - 0.083 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Tropomodulin PF03250.14 PIK50448.1 - 2.8e-50 170.0 5.7 2.8e-50 170.0 5.7 2.4 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.6 PIK50448.1 - 1.6e-05 24.6 5.5 0.038 14.0 0.1 4.0 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 PIK50448.1 - 0.00072 19.9 5.8 0.042 14.3 0.5 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK50448.1 - 0.031 14.8 0.2 2 9.3 0.1 2.9 3 0 0 3 3 3 0 Leucine Rich Repeat MgtE_N PF03448.17 PIK50448.1 - 0.12 13.0 4.4 0.36 11.5 1.6 2.8 2 0 0 2 2 2 0 MgtE intracellular N domain FumaraseC_C PF10415.9 PIK50448.1 - 0.3 11.5 3.2 3.2 8.2 0.0 3.6 3 1 1 4 4 4 0 Fumarase C C-terminus STI1 PF17830.1 PIK50448.1 - 0.44 10.5 5.2 6.5 6.8 0.8 3.7 3 0 0 3 3 3 0 STI1 domain Cullin PF00888.22 PIK50449.1 - 2.2e-186 621.2 20.9 2.2e-186 621.2 20.9 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 PIK50449.1 - 2.8e-27 94.6 11.2 1.7e-26 92.0 5.1 3.7 3 0 0 3 3 3 1 Cullin protein neddylation domain Phage_TAC_12 PF12363.8 PIK50449.1 - 0.022 15.2 0.7 0.084 13.3 0.1 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC L27_1 PF09058.10 PIK50449.1 - 0.033 14.2 1.4 3.2 7.8 0.0 3.7 2 0 0 2 2 2 0 L27_1 Kazal_2 PF07648.15 PIK50450.1 - 0.0031 17.6 3.1 0.005 16.9 3.1 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK50450.1 - 0.031 14.3 1.1 0.048 13.7 1.1 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Complex1_LYR_2 PF13233.6 PIK50451.1 - 6.9e-13 49.2 0.0 1e-12 48.6 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 PIK50451.1 - 2.7e-06 27.3 0.3 2.7e-06 27.3 0.3 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Rdx PF10262.9 PIK50452.1 - 3.4e-05 24.0 0.0 6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Rdx family Cupin_8 PF13621.6 PIK50453.1 - 4.5e-34 118.3 0.6 6.9e-34 117.7 0.6 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK50453.1 - 2.4e-12 46.9 0.5 6.5e-12 45.5 0.2 1.7 1 1 1 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 PIK50453.1 - 4.5e-07 30.3 0.3 1.1e-06 29.1 0.3 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 PIK50453.1 - 0.018 14.7 1.2 0.028 14.1 0.0 1.9 2 0 0 2 2 2 0 Cupin domain Peptidase_C1 PF00112.23 PIK50454.1 - 1.2e-84 283.7 3.9 1.2e-84 283.7 3.9 1.3 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK50454.1 - 4.9e-13 49.3 0.7 8.2e-13 48.6 0.7 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK50454.1 - 0.00023 20.1 2.0 0.031 13.1 0.8 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Peptidase_C1 PF00112.23 PIK50455.1 - 1.7e-70 237.6 0.4 1.7e-70 237.6 0.4 1.4 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK50455.1 - 7.4e-14 51.9 2.4 1.2e-13 51.3 2.4 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK50455.1 - 9.1e-05 21.4 0.8 0.00053 18.9 0.3 2.1 2 0 0 2 2 2 1 Peptidase C1-like family bZIP_Maf PF03131.17 PIK50456.1 - 6.4e-16 58.7 0.4 1.3e-15 57.6 0.4 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 PIK50456.1 - 3e-08 33.7 3.1 8.3e-08 32.2 3.1 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK50456.1 - 0.0026 17.8 4.5 0.0026 17.8 4.5 2.2 3 0 0 3 3 3 1 Basic region leucine zipper GAS PF13851.6 PIK50456.1 - 0.037 13.4 2.3 0.081 12.3 2.3 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HOOK PF05622.12 PIK50456.1 - 1.4 6.9 8.3 0.035 12.3 1.5 1.6 2 0 0 2 2 2 0 HOOK protein Clat_adaptor_s PF01217.20 PIK50458.1 - 1.6e-32 112.4 0.9 1.9e-32 112.2 0.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AAA_18 PF13238.6 PIK50458.1 - 0.0069 16.9 0.1 0.032 14.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain Homeodomain PF00046.29 PIK50459.1 - 7.4e-21 73.8 9.4 1.1e-20 73.2 9.4 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK50459.1 - 0.0094 15.8 0.5 0.017 15.0 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK50459.1 - 0.02 14.4 0.6 0.027 13.9 0.6 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Peptidase_S49_N PF08496.10 PIK50459.1 - 4.4 7.4 6.6 6.2 6.9 6.6 1.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Homeodomain PF00046.29 PIK50460.1 - 2e-20 72.4 7.4 3.5e-20 71.6 7.4 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK50460.1 - 0.014 15.3 0.3 0.041 13.8 0.3 1.8 1 0 0 1 1 1 0 Homeobox KN domain GPHR_N PF12537.8 PIK50460.1 - 0.12 12.5 0.1 0.32 11.1 0.1 1.7 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Homeodomain PF00046.29 PIK50461.1 - 4.1e-20 71.4 7.0 8.4e-20 70.4 7.0 1.5 1 0 0 1 1 1 1 Homeodomain NAM-associated PF14303.6 PIK50461.1 - 0.23 12.2 15.5 0.42 11.3 15.5 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain GREB1 PF15782.5 PIK50461.1 - 1.1 6.3 11.1 1.3 6.0 11.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SR-25 PF10500.9 PIK50461.1 - 2.3 7.8 21.5 1.7 8.2 10.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Homeodomain PF00046.29 PIK50462.1 - 1.4e-09 37.6 2.0 3.1e-09 36.5 2.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 PIK50463.1 - 7.1e-22 77.0 8.1 9.2e-22 76.7 8.1 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK50463.1 - 0.0082 16.0 0.5 0.014 15.2 0.5 1.4 1 0 0 1 1 1 1 Homeobox KN domain RRM PF10378.9 PIK50464.1 - 0.015 15.0 0.5 0.015 15.0 0.5 2.8 3 0 0 3 3 3 0 Putative RRM domain Homeodomain PF00046.29 PIK50465.1 - 3.5e-20 71.6 6.7 7.2e-20 70.6 6.7 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK50465.1 - 0.044 13.7 0.5 0.11 12.4 0.5 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 PIK50466.1 - 2.5e-13 49.7 0.9 4.1e-13 49.0 0.9 1.3 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 PIK50467.1 - 2.7e-22 78.3 5.4 5.1e-22 77.5 5.4 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK50467.1 - 0.43 10.5 1.8 0.75 9.8 0.4 2.1 2 0 0 2 2 2 0 Homeobox KN domain Peptidase_M1_N PF17900.1 PIK50468.1 - 3.8e-24 85.9 0.0 4.8e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 PIK50469.1 - 2.4e-49 167.8 0.3 3.4e-49 167.4 0.3 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 PIK50469.1 - 1.6e-31 108.7 0.0 3.4e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.6 PIK50469.1 - 0.038 13.7 0.0 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase MA superfamily Pkinase PF00069.25 PIK50470.1 - 1.3e-15 57.5 0.0 1.8e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50470.1 - 1.6e-10 40.7 0.0 2.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SMP_LBD PF17047.5 PIK50470.1 - 0.14 11.6 0.0 0.54 9.7 0.0 1.8 1 1 0 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain Kdo PF06293.14 PIK50470.1 - 0.16 11.3 0.0 5.3 6.3 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.7 PIK50471.1 - 3.4e-30 104.5 3.4 9.2e-11 42.2 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 PIK50471.1 - 9.8e-28 95.4 14.4 1.6e-06 28.3 0.0 6.3 5 1 1 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 PIK50471.1 - 3.8e-27 94.3 6.7 8.8e-09 35.7 0.1 5.7 3 3 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK50471.1 - 1.4e-23 80.4 7.2 0.00014 22.0 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK50471.1 - 2.3e-22 78.8 9.6 1.4e-07 31.6 0.2 5.6 2 1 4 6 6 6 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 PIK50471.1 - 0.01 16.2 0.2 0.019 15.3 0.2 1.5 1 0 0 1 1 1 0 SOCS box zf-CHCC PF10276.9 PIK50472.1 - 4.8e-19 68.1 2.2 8.1e-19 67.4 2.2 1.4 1 0 0 1 1 1 1 Zinc-finger domain Thiolase_C PF02803.18 PIK50472.1 - 0.019 14.6 0.0 0.43 10.2 0.0 2.2 2 0 0 2 2 2 0 Thiolase, C-terminal domain Peptidase_M24 PF00557.24 PIK50473.1 - 4e-60 203.1 0.1 5e-60 202.8 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 PIK50473.1 - 2.1e-23 82.4 0.0 4.4e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 PIK50473.1 - 0.042 13.9 0.0 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Snf7 PF03357.21 PIK50474.1 - 6e-44 149.7 17.6 7.1e-44 149.4 17.6 1.1 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.12 PIK50474.1 - 0.043 14.2 5.3 0.066 13.6 5.3 1.2 1 0 0 1 1 1 0 SYF2 splicing factor CK2S PF15011.6 PIK50474.1 - 0.05 13.5 3.7 0.048 13.5 2.6 1.6 1 1 0 1 1 1 0 Casein Kinase 2 substrate HAT_KAT11 PF08214.11 PIK50474.1 - 0.15 11.3 1.7 0.22 10.8 1.7 1.1 1 0 0 1 1 1 0 Histone acetylation protein V_ATPase_I PF01496.19 PIK50474.1 - 0.61 7.9 5.7 0.78 7.6 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 PIK50474.1 - 1.1 9.5 6.1 2.8 8.2 3.9 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) dNK PF01712.19 PIK50475.1 - 1.6e-51 175.0 0.1 2.1e-51 174.7 0.1 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 PIK50475.1 - 0.0039 17.7 0.1 0.015 15.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK50475.1 - 0.0046 17.1 0.0 0.13 12.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 PIK50475.1 - 0.0078 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 PIK50475.1 - 0.009 16.0 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 PIK50475.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 PIK50475.1 - 0.045 14.1 0.0 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 PIK50475.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 PIK50475.1 - 0.073 13.3 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK50475.1 - 0.095 13.2 0.0 0.14 12.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 PIK50475.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain IRF-3 PF10401.9 PIK50476.1 - 1.2e-12 48.0 0.0 4.1e-11 43.0 0.0 2.2 1 1 0 1 1 1 1 Interferon-regulatory factor 3 MH2 PF03166.14 PIK50476.1 - 8e-05 22.9 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 MH2 domain IRF-3 PF10401.9 PIK50477.1 - 3.7e-22 79.0 0.1 6.1e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MH2 PF03166.14 PIK50477.1 - 9.3e-05 22.7 0.1 0.00019 21.7 0.1 1.5 1 0 0 1 1 1 1 MH2 domain UQ_con PF00179.26 PIK50478.1 - 7.5e-17 61.3 0.0 8.9e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK50478.1 - 0.096 13.0 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain HEAT PF02985.22 PIK50479.1 - 0.001 19.2 0.1 0.38 11.1 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat KdpD PF02702.17 PIK50479.1 - 0.0016 18.0 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain RICTOR_N PF14664.6 PIK50479.1 - 0.037 13.0 0.9 0.48 9.3 0.0 2.5 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term DUF4371 PF14291.6 PIK50480.1 - 0.0001 22.0 0.6 0.00016 21.4 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) zf-BED PF02892.15 PIK50480.1 - 0.0003 20.7 0.0 0.0012 18.8 0.0 2.1 1 0 0 1 1 1 1 BED zinc finger zf-H2C2_5 PF13909.6 PIK50480.1 - 0.019 14.7 0.2 0.059 13.1 0.2 1.9 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_12 PF18658.1 PIK50480.1 - 0.021 14.4 0.4 0.48 10.0 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger C2H2-type Pkinase PF00069.25 PIK50483.1 - 3e-62 210.4 0.0 3.4e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50483.1 - 2.2e-32 112.3 0.0 3e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK50483.1 - 4.3e-07 29.5 0.0 0.00037 19.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 PIK50483.1 - 0.024 13.6 0.1 0.093 11.7 0.1 1.8 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 PIK50483.1 - 0.095 12.3 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 PIK50483.1 - 0.13 12.1 0.1 0.25 11.2 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK50483.1 - 0.15 10.8 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase zf-C2H2 PF00096.26 PIK50484.1 - 4.5e-21 74.1 87.4 0.00027 21.2 0.5 12.6 12 0 0 12 12 11 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK50484.1 - 2.4e-18 65.2 96.1 0.0025 18.5 1.0 12.9 13 0 0 13 13 12 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK50484.1 - 9.1e-08 32.2 6.8 8.2e-06 26.0 0.1 12.7 15 0 0 15 15 14 5 Zinc-finger double domain zf-C2H2_8 PF15909.5 PIK50484.1 - 0.0001 22.5 32.4 0.02 15.2 1.3 6.1 2 1 4 6 6 6 3 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 PIK50484.1 - 0.00036 20.5 0.3 0.00036 20.5 0.3 11.4 11 1 1 12 12 12 5 C2H2-type zinc finger zf-met PF12874.7 PIK50484.1 - 0.0065 16.8 51.3 0.035 14.5 1.1 9.5 10 0 0 10 10 10 4 Zinc-finger of C2H2 type BCS1_N PF08740.11 PIK50484.1 - 0.084 12.9 0.2 0.21 11.5 0.2 1.7 1 0 0 1 1 1 0 BCS1 N terminal zf-C2H2_11 PF16622.5 PIK50484.1 - 0.19 11.5 0.0 0.19 11.5 0.0 7.3 8 0 0 8 8 7 0 zinc-finger C2H2-type Sporozoite_P67 PF05642.11 PIK50484.1 - 0.46 8.5 3.3 0.81 7.7 3.3 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PRP21_like_P PF12230.8 PIK50484.1 - 0.88 9.4 14.9 0.031 14.1 2.9 3.1 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein zf-C2H2_jaz PF12171.8 PIK50484.1 - 0.93 9.9 68.5 0.45 10.9 0.3 10.8 12 0 0 12 12 11 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 PIK50484.1 - 6.3 6.9 23.8 5.2 7.1 0.1 6.8 5 2 2 7 7 7 0 CpXC protein FAM176 PF14851.6 PIK50484.1 - 7.3 6.2 9.9 1.3 8.7 1.9 2.5 2 0 0 2 2 2 0 FAM176 family zf-C2H2_4 PF13894.6 PIK50485.1 - 0.0015 19.2 5.6 0.12 13.3 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_9 PF16293.5 PIK50485.1 - 0.0018 18.0 1.1 0.0073 16.1 0.2 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 PIK50485.1 - 0.0031 17.8 2.5 0.12 12.6 0.1 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.12 PIK50485.1 - 0.021 13.4 0.5 0.91 8.0 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 PIK50485.1 - 0.025 15.0 6.9 1.4 9.6 0.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 PIK50485.1 - 0.031 14.3 4.9 0.94 9.6 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf_UBZ PF18439.1 PIK50485.1 - 0.031 13.9 0.9 1.1 8.9 0.1 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 PIK50485.1 - 0.033 14.6 2.6 0.66 10.4 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Dppa2_A PF14049.6 PIK50485.1 - 0.046 13.9 0.2 0.11 12.7 0.2 1.6 1 0 0 1 1 1 0 Dppa2/4 conserved region in higher vertebrates zf-C2H2_jaz PF12171.8 PIK50485.1 - 0.052 13.8 7.5 0.098 13.0 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK50485.1 - 0.09 13.1 2.7 2.5 8.5 0.0 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 PIK50485.1 - 0.2 11.8 2.5 2.6 8.3 0.8 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-XS PF03470.14 PIK50485.1 - 2.7 8.3 5.8 10 6.5 0.9 2.7 2 0 0 2 2 2 0 XS zinc finger domain DUF1279 PF06916.13 PIK50486.1 - 1.4e-22 80.0 2.2 2e-22 79.5 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) HSP9_HSP12 PF04119.12 PIK50486.1 - 0.19 12.1 0.8 0.49 10.8 0.8 1.6 1 0 0 1 1 1 0 Heat shock protein 9/12 IMPDH PF00478.25 PIK50487.1 - 2.3e-17 63.0 0.0 2.5e-17 62.9 0.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Aldolase PF01081.19 PIK50487.1 - 0.031 13.7 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 KDPG and KHG aldolase IMPDH PF00478.25 PIK50488.1 - 2.6e-12 46.4 0.2 2.8e-12 46.3 0.2 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 PIK50488.1 - 0.0025 16.9 0.3 0.003 16.7 0.3 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ABC2_membrane_3 PF12698.7 PIK50489.1 - 1.4e-51 175.6 15.3 2.3e-51 174.9 15.3 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 PIK50489.1 - 1.2e-21 77.6 0.0 2.6e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 PIK50489.1 - 2.6e-09 37.4 0.0 1.7e-07 31.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 PIK50489.1 - 6.5e-06 26.8 0.1 0.08 13.7 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) ABC2_membrane_3 PF12698.7 PIK50490.1 - 7.7e-22 77.9 23.8 1e-21 77.4 23.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 PIK50490.1 - 6.4e-17 62.4 0.0 1.1e-16 61.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 PIK50490.1 - 0.013 15.5 0.1 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 PIK50490.1 - 0.018 15.6 0.2 0.029 14.9 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK50490.1 - 0.02 14.6 0.3 0.047 13.4 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 PIK50490.1 - 0.03 14.1 0.1 0.056 13.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MukB PF04310.12 PIK50490.1 - 0.065 13.0 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 MukB N-terminal AAA_15 PF13175.6 PIK50490.1 - 0.18 11.5 0.1 0.38 10.4 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain DUF4436 PF14494.6 PIK50490.1 - 1.8 7.8 5.3 3.5 6.8 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4436) Cytomega_UL20A PF05984.12 PIK50492.1 - 0.25 11.7 1.3 10 6.5 0.1 2.2 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein RHD_dimer PF16179.5 PIK50493.1 - 3.2e-18 65.6 0.0 7.2e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 PIK50493.1 - 2.7e-15 56.7 0.3 9e-15 55.0 0.3 1.9 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.24 PIK50493.1 - 0.00022 21.2 0.0 0.0015 18.6 0.0 2.5 1 0 0 1 1 1 1 IPT/TIG domain zf-CHCC PF10276.9 PIK50493.1 - 0.038 14.0 0.2 0.36 10.9 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger domain NUDIX PF00293.28 PIK50494.1 - 8e-14 51.8 0.0 1.3e-13 51.1 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain Beta_helix PF13229.6 PIK50495.1 - 2.2e-10 40.6 4.3 3.9e-10 39.8 4.3 1.3 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 PIK50495.1 - 3.5e-05 23.2 1.4 9.2e-05 21.8 1.4 1.6 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Mannitol_dh_C PF08125.13 PIK50495.1 - 0.056 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain APS_kinase PF01583.20 PIK50495.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase zf-H2C2_2 PF13465.6 PIK50496.1 - 2.3e-13 49.9 19.8 3.1e-08 33.7 0.1 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK50496.1 - 4.8e-11 42.5 20.4 6.8e-06 26.2 1.4 3.6 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK50496.1 - 3.1e-08 33.8 18.5 0.00067 20.3 1.1 3.6 4 0 0 4 4 3 3 C2H2-type zinc finger zf-met PF12874.7 PIK50496.1 - 4.7e-05 23.6 8.0 0.031 14.7 0.4 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK50496.1 - 0.00087 19.1 4.5 3 7.8 0.1 3.3 3 0 0 3 3 3 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-AN1 PF01428.16 PIK50496.1 - 0.0045 17.1 7.8 0.4 10.9 0.3 3.3 3 0 0 3 3 3 1 AN1-like Zinc finger zf-C2H2_8 PF15909.5 PIK50496.1 - 0.006 16.9 1.2 0.1 12.9 0.1 2.2 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-Di19 PF05605.12 PIK50496.1 - 0.011 16.0 2.2 0.011 16.0 2.2 2.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 PIK50496.1 - 0.016 15.5 8.5 0.59 10.5 0.2 2.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 PIK50496.1 - 0.025 15.0 10.2 0.31 11.5 0.4 3.1 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.8 PIK50496.1 - 0.048 14.0 1.5 0.26 11.6 0.3 2.0 2 0 0 2 2 2 0 zinc-finger-containing domain zf-BED PF02892.15 PIK50496.1 - 0.055 13.5 8.2 7 6.8 0.9 3.4 2 1 1 3 3 3 0 BED zinc finger Prok-RING_1 PF14446.6 PIK50496.1 - 0.056 13.4 2.5 12 5.9 0.1 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Zn_ribbon_SprT PF17283.2 PIK50496.1 - 0.061 13.2 8.5 0.12 12.3 3.7 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_jaz PF12171.8 PIK50496.1 - 0.064 13.6 0.1 0.064 13.6 0.1 3.1 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_4 PF13717.6 PIK50496.1 - 0.086 12.8 5.8 2.6 8.0 0.4 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_6 PF13912.6 PIK50496.1 - 0.1 12.6 0.7 0.1 12.6 0.7 3.9 4 1 0 4 4 3 0 C2H2-type zinc finger zf-FCS PF06467.14 PIK50496.1 - 0.12 12.4 6.8 6.2 6.9 0.1 3.3 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif YhfH PF14149.6 PIK50496.1 - 0.15 12.0 2.5 4.1 7.5 0.0 2.6 3 0 0 3 3 3 0 YhfH-like protein Zn-ribbon_8 PF09723.10 PIK50496.1 - 0.21 11.7 9.0 1.5 9.0 4.6 3.0 2 1 1 3 3 3 0 Zinc ribbon domain zf-LYAR PF08790.11 PIK50496.1 - 0.25 11.3 8.0 2.5 8.1 0.5 2.8 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zinc-ribbons_6 PF07191.12 PIK50496.1 - 0.25 11.3 3.2 3.2 7.8 1.4 2.7 2 1 1 3 3 3 0 zinc-ribbons FYDLN_acid PF09538.10 PIK50496.1 - 0.26 12.0 0.8 16 6.2 0.0 2.4 2 1 1 3 3 2 0 Protein of unknown function (FYDLN_acid) FYVE PF01363.21 PIK50496.1 - 0.31 11.2 6.5 3.4 7.9 4.2 2.4 1 1 1 2 2 2 0 FYVE zinc finger zf-CHCC PF10276.9 PIK50496.1 - 0.34 11.0 7.7 7.2 6.7 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger domain Zf_RING PF16744.5 PIK50496.1 - 0.39 10.9 5.5 3.7 7.7 0.1 3.0 2 1 1 3 3 3 0 KIAA1045 RING finger zf-C2HC_2 PF13913.6 PIK50496.1 - 0.55 10.2 10.8 0.7 9.9 0.7 3.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-nanos PF05741.13 PIK50496.1 - 1.3 9.3 7.6 1.6 9.0 3.1 2.8 2 1 0 2 2 2 0 Nanos RNA binding domain LIM PF00412.22 PIK50496.1 - 1.7 8.9 7.3 3.3 8.0 0.4 2.8 2 1 1 3 3 3 0 LIM domain zf_UBZ PF18439.1 PIK50496.1 - 2 8.1 4.7 6.5 6.4 0.1 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger HNH_5 PF14279.6 PIK50496.1 - 2 8.3 8.5 6.2 6.8 0.1 2.8 3 0 0 3 3 3 0 HNH endonuclease Desulfoferrod_N PF06397.12 PIK50496.1 - 2.2 8.0 6.5 4.6 7.0 0.4 3.0 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_11 PF16622.5 PIK50496.1 - 2.9 7.7 8.5 0.6 9.9 0.3 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 PIK50497.1 - 1.5e-07 31.6 29.3 0.025 15.4 0.3 4.6 3 1 1 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK50497.1 - 2.5e-05 24.5 3.6 2.5e-05 24.5 3.6 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-CHCC PF10276.9 PIK50497.1 - 0.0053 16.8 8.7 3.4 7.8 0.2 3.6 3 1 1 4 4 4 2 Zinc-finger domain PyrI_C PF02748.15 PIK50497.1 - 0.0055 16.6 16.9 0.5 10.3 0.6 4.1 1 1 3 4 4 4 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 PF00096.26 PIK50497.1 - 0.0068 16.8 36.3 0.048 14.1 6.2 4.4 3 1 1 4 4 4 3 Zinc finger, C2H2 type HypA PF01155.19 PIK50497.1 - 0.019 15.0 1.8 0.019 15.0 1.8 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.8 PIK50497.1 - 0.2 12.0 17.2 0.27 11.6 1.0 4.4 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.21 PIK50497.1 - 0.51 10.5 25.9 1.3 9.2 15.5 3.5 1 1 2 3 3 3 0 FYVE zinc finger YyzF PF14116.6 PIK50497.1 - 0.81 9.8 13.7 15 5.7 0.9 4.1 3 1 1 4 4 4 0 YyzF-like protein Zf_RING PF16744.5 PIK50497.1 - 3.1 8.0 15.9 11 6.2 4.8 4.1 1 1 2 3 3 3 0 KIAA1045 RING finger zf-BED PF02892.15 PIK50497.1 - 3.2 7.9 19.5 16 5.6 1.5 4.3 1 1 3 4 4 4 0 BED zinc finger zf-AN1 PF01428.16 PIK50497.1 - 3.7 7.8 22.7 1.9 8.7 0.3 4.3 3 1 0 4 4 4 0 AN1-like Zinc finger zf-C2HC5 PF06221.13 PIK50497.1 - 4.2 7.4 11.0 7.8 6.6 0.3 3.8 1 1 3 4 4 4 0 Putative zinc finger motif, C2HC5-type HNH_5 PF14279.6 PIK50497.1 - 9.5 6.2 18.0 24 4.9 0.4 4.1 4 0 0 4 4 4 0 HNH endonuclease PapC_C PF13953.6 PIK50498.1 - 0.0023 17.7 0.0 0.0025 17.6 0.0 1.1 1 0 0 1 1 1 1 PapC C-terminal domain GCV_T PF01571.21 PIK50499.1 - 1.4e-07 31.1 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain RT_RNaseH PF17917.1 PIK50500.1 - 4.4e-32 110.5 0.1 9.1e-32 109.5 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK50500.1 - 8e-30 102.8 0.1 1.6e-29 101.8 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50500.1 - 4.6e-11 42.6 0.1 9e-06 25.4 0.1 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK50500.1 - 0.00026 21.0 0.2 0.00078 19.5 0.0 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 PIK50500.1 - 0.025 15.1 0.0 0.054 14.1 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Antigen_Bd37 PF11641.8 PIK50500.1 - 0.072 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein DUF4207 PF13904.6 PIK50501.1 - 1.8e-20 73.7 65.3 1.8e-20 73.7 65.3 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4207) rve PF00665.26 PIK50501.1 - 6.1e-20 71.6 0.0 1.5e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50501.1 - 0.034 13.9 0.0 0.14 11.9 0.0 2.1 1 0 0 1 1 1 0 Integrase core domain Macoilin PF09726.9 PIK50501.1 - 3.6 6.0 40.0 6.2 5.3 40.0 1.3 1 0 0 1 1 1 0 Macoilin family zf-C3HC4_3 PF13920.6 PIK50502.1 - 3.8e-11 42.6 10.7 3.8e-11 42.6 10.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SWIB PF02201.18 PIK50502.1 - 2.1e-07 30.7 0.0 4.2e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-RanBP PF00641.18 PIK50502.1 - 4.1e-05 22.8 5.4 0.00014 21.1 5.4 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.7 PIK50502.1 - 0.74 9.9 17.6 1.1 9.3 2.3 2.8 2 0 0 2 2 2 0 Double zinc ribbon UEV PF05743.13 PIK50503.1 - 3.5e-44 149.6 0.1 6.2e-44 148.7 0.1 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 PIK50503.1 - 5.9e-24 83.8 0.3 5.9e-24 83.8 0.3 1.9 2 0 0 2 2 2 1 Vps23 core domain DUF737 PF05300.11 PIK50503.1 - 0.0002 21.8 0.3 0.00035 21.0 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) AAA_13 PF13166.6 PIK50503.1 - 0.0029 16.3 4.1 0.0039 15.9 4.1 1.1 1 0 0 1 1 1 1 AAA domain Hormone_1 PF00103.20 PIK50503.1 - 0.0046 16.7 1.9 0.0075 16.0 1.9 1.4 1 0 0 1 1 1 1 Somatotropin hormone family DUF3053 PF11254.8 PIK50503.1 - 0.027 14.1 3.7 0.045 13.3 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Herpes_UL6 PF01763.16 PIK50503.1 - 0.027 13.0 2.1 0.036 12.6 2.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Exonuc_VII_L PF02601.15 PIK50503.1 - 0.043 13.4 3.2 0.056 13.0 3.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PL48 PF15903.5 PIK50503.1 - 0.13 11.2 5.0 0.22 10.5 5.0 1.2 1 0 0 1 1 1 0 Filopodia upregulated, FAM65 Arc_PepC_II PF06847.11 PIK50503.1 - 0.13 12.8 0.5 0.92 10.1 0.0 2.5 1 1 2 3 3 2 0 Archaeal Peptidase A24 C-terminus Type II TMPIT PF07851.13 PIK50503.1 - 0.17 11.1 3.1 0.24 10.6 3.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein Peptidase_S46 PF10459.9 PIK50503.1 - 0.2 10.2 8.3 0.25 10.0 8.3 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF4164 PF13747.6 PIK50503.1 - 0.35 11.2 8.1 0.76 10.1 8.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) FapA PF03961.13 PIK50503.1 - 0.36 9.4 5.5 0.49 8.9 5.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 PIK50503.1 - 0.4 11.0 8.4 0.23 11.7 5.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ADIP PF11559.8 PIK50503.1 - 0.59 10.2 12.9 0.19 11.8 10.1 1.5 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding COG2 PF06148.11 PIK50503.1 - 0.6 10.2 8.2 2.4 8.3 8.1 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin-6_N PF09177.11 PIK50503.1 - 0.85 10.2 7.4 1.1 9.8 6.0 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Spc7 PF08317.11 PIK50503.1 - 1.5 7.6 13.7 2.5 6.9 13.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 PIK50503.1 - 2.2 6.7 3.5 2.9 6.3 3.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DivIC PF04977.15 PIK50503.1 - 2.7 7.8 11.5 4.9 7.0 6.6 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF1664 PF07889.12 PIK50503.1 - 2.8 8.0 6.2 5.1 7.2 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) AAA_23 PF13476.6 PIK50503.1 - 3.2 8.2 7.9 5.7 7.4 7.9 1.4 1 0 0 1 1 1 0 AAA domain FlaC_arch PF05377.11 PIK50503.1 - 3.5 8.1 10.4 8.2 6.9 6.8 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 PIK50503.1 - 6 7.4 18.4 0.56 10.7 13.6 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region KxDL PF10241.9 PIK50503.1 - 6.7 7.1 10.4 19 5.6 8.1 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF3987 PF13148.6 PIK50503.1 - 9.5 5.1 10.7 1.2e+02 1.5 10.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3987) Phage_integrase PF00589.22 PIK50505.1 - 9.1e-05 22.3 0.0 0.00034 20.5 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family IRS PF02174.17 PIK50506.1 - 1.3e-15 57.1 0.0 2.3e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Pec_lyase_N PF04431.13 PIK50506.1 - 0.08 13.2 0.3 0.14 12.4 0.3 1.4 1 0 0 1 1 1 0 Pectate lyase, N terminus Nup192 PF11894.8 PIK50508.1 - 1.2e-185 619.4 0.0 2e-185 618.7 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 HSR PF03172.13 PIK50508.1 - 0.11 12.7 0.1 0.48 10.6 0.0 2.1 2 0 0 2 2 2 0 HSR domain Nup192 PF11894.8 PIK50509.1 - 5.2e-47 159.9 0.0 5.5e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Nup192 PF11894.8 PIK50510.1 - 3.3e-52 177.1 3.3 1e-39 135.7 1.5 2.1 1 1 1 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 DUF4430 PF14478.6 PIK50511.1 - 2.2e-06 28.2 0.1 3.1e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) BNR_2 PF13088.6 PIK50513.1 - 3.2e-19 69.3 0.0 5.1e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 PIK50513.1 - 1.9e-06 27.4 0.0 3.1e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK50513.1 - 0.0016 18.1 6.9 1.9 8.8 0.4 4.2 4 0 0 4 4 4 2 BNR/Asp-box repeat vATP-synt_E PF01991.18 PIK50514.1 - 8.6e-12 44.9 0.1 1.1e-11 44.5 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Acyl-CoA_dh_1 PF00441.24 PIK50515.1 - 7.9e-36 123.5 0.2 1.9e-19 70.3 0.1 2.1 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK50515.1 - 2.3e-21 75.8 0.0 4.2e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK50515.1 - 4.1e-08 33.6 0.0 1.9e-07 31.4 0.0 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Myosin_head PF00063.21 PIK50516.1 - 3.6e-108 362.6 0.1 4.3e-108 362.3 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 PIK50516.1 - 0.0057 17.1 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK50516.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK50516.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 PIK50516.1 - 0.11 13.0 0.4 0.14 12.7 0.4 1.4 1 1 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 PIK50516.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RRM_1 PF00076.22 PIK50517.1 - 1.4e-22 79.3 0.1 4.6e-12 45.6 0.2 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 PF00013.29 PIK50517.1 - 3.9e-17 61.8 1.5 9.9e-17 60.5 0.7 2.1 2 0 0 2 2 2 1 KH domain Limkain-b1 PF11608.8 PIK50517.1 - 1.4e-05 25.1 0.2 0.043 13.9 0.1 2.4 1 1 1 2 2 2 2 Limkain b1 DbpA PF03880.15 PIK50517.1 - 9.6e-05 22.3 1.3 0.018 15.0 0.1 3.2 3 0 0 3 3 3 1 DbpA RNA binding domain KH_2 PF07650.17 PIK50517.1 - 0.00093 19.0 0.1 0.00093 19.0 0.1 2.1 3 0 0 3 3 3 1 KH domain RRM_5 PF13893.6 PIK50517.1 - 0.0016 18.0 0.0 0.028 14.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_5 PF13184.6 PIK50517.1 - 0.0045 17.1 0.2 0.011 15.7 0.2 1.6 1 0 0 1 1 1 1 NusA-like KH domain RRM_3 PF08777.11 PIK50517.1 - 0.016 15.3 0.0 0.086 12.9 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 PIK50517.1 - 0.019 14.8 0.2 6.2 6.8 0.0 2.9 2 1 0 2 2 2 0 Occluded RNA-recognition motif KH_4 PF13083.6 PIK50517.1 - 0.041 13.8 0.0 0.22 11.4 0.0 2.3 1 0 0 1 1 1 0 KH domain KH_1 PF00013.29 PIK50518.1 - 3.8e-18 65.1 4.3 6.8e-08 32.2 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 PIK50518.1 - 0.005 16.6 1.3 0.95 9.3 0.1 2.6 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 PIK50518.1 - 0.0079 16.1 0.1 3.6 7.5 0.0 2.6 2 0 0 2 2 2 2 KH domain UCH PF00443.29 PIK50519.1 - 3.8e-42 144.6 0.0 1.6e-36 126.1 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK50519.1 - 1.9e-21 77.0 0.5 9e-21 74.8 0.0 2.3 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 PIK50519.1 - 0.0084 15.8 7.7 0.12 12.2 0.1 4.9 4 2 0 4 4 4 1 Ubiquitin family YukD PF08817.10 PIK50519.1 - 0.044 14.5 0.2 19 6.0 0.0 3.4 4 0 0 4 4 4 0 WXG100 protein secretion system (Wss), protein YukD S-methyl_trans PF02574.16 PIK50520.1 - 1.7e-24 87.1 0.0 2.2e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Cpn60_TCP1 PF00118.24 PIK50521.1 - 1.3e-16 60.3 0.0 2.1e-15 56.4 0.0 2.3 3 0 0 3 3 3 2 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 PIK50522.1 - 8.3e-09 34.6 0.2 9.9e-09 34.3 0.2 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TPR_12 PF13424.6 PIK50523.1 - 4.9e-19 68.4 4.7 2.3e-08 34.2 0.1 4.1 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 PIK50523.1 - 2.1e-11 43.3 6.5 0.01 15.7 0.6 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK50523.1 - 9.3e-11 41.0 12.6 0.0005 20.0 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK50523.1 - 6.5e-10 39.0 2.7 0.013 16.2 0.1 4.2 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK50523.1 - 5.6e-09 35.5 13.3 0.00065 19.7 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK50523.1 - 4e-08 33.8 2.0 0.024 15.3 0.1 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK50523.1 - 2.6e-07 30.2 19.8 0.00092 18.9 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK50523.1 - 3.9e-07 30.5 7.1 0.014 15.9 0.1 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK50523.1 - 2.8e-05 23.7 0.1 0.00016 21.2 0.0 2.0 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 PIK50523.1 - 0.00023 21.0 7.0 0.0033 17.3 0.2 3.9 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK50523.1 - 0.00078 19.5 0.9 0.0065 16.5 0.4 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_17 PF13431.6 PIK50523.1 - 0.0027 18.0 8.9 0.064 13.7 0.1 4.1 4 2 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK50523.1 - 0.0036 17.4 0.5 0.23 11.5 0.2 2.9 1 1 1 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_15 PF13429.6 PIK50523.1 - 0.0039 16.4 0.3 0.0073 15.6 0.3 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat Chaperone_III PF07824.12 PIK50523.1 - 0.0071 16.6 0.1 0.016 15.4 0.1 1.6 1 0 0 1 1 1 1 Type III secretion chaperone domain TPR_9 PF13371.6 PIK50523.1 - 0.024 14.8 0.0 1.7 8.9 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4031 PF13223.6 PIK50523.1 - 0.04 14.1 0.0 0.071 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4031) T3SchapCesA PF11439.8 PIK50523.1 - 0.064 13.4 0.7 0.16 12.1 0.1 1.9 2 0 0 2 2 2 0 Type III secretion system filament chaperone CesA DUF2802 PF10975.8 PIK50523.1 - 0.079 13.1 0.5 13 6.0 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2802) MIT PF04212.18 PIK50523.1 - 3.8 7.7 10.7 26 5.0 0.2 4.3 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain Cytochrom_B561 PF03188.16 PIK50524.1 - 2.4e-31 108.7 9.9 2.4e-31 108.7 9.9 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 Insulin_TMD PF17870.1 PIK50524.1 - 0.023 14.7 1.3 0.023 14.7 1.3 3.0 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment SHR3_chaperone PF08229.11 PIK50524.1 - 0.33 9.9 4.1 0.1 11.5 0.4 1.8 1 1 1 2 2 2 0 ER membrane protein SH3 Abhydrolase_9_N PF15420.6 PIK50524.1 - 0.66 10.0 4.6 12 5.9 4.3 2.4 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus DUF2106 PF09879.9 PIK50524.1 - 1.3 8.5 4.3 1.1 8.7 1.5 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2106) GPI2 PF06432.11 PIK50524.1 - 2.9 7.3 9.2 0.63 9.4 3.2 2.0 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase PepSY_TM PF03929.16 PIK50524.1 - 8.3 6.0 13.4 3.1 7.4 1.2 2.4 1 1 1 2 2 2 0 PepSY-associated TM region DUF4079 PF13301.6 PIK50524.1 - 9.2 6.4 10.2 33 4.6 9.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Cytochrom_B561 PF03188.16 PIK50525.1 - 2.3e-21 76.4 4.5 2.5e-21 76.3 4.5 1.1 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 ABC_trans_CmpB PF06541.11 PIK50525.1 - 0.0092 16.2 1.7 0.012 15.8 1.7 1.2 1 0 0 1 1 1 1 Putative ABC-transporter type IV FLILHELTA PF10306.9 PIK50525.1 - 0.037 14.4 0.4 0.1 13.0 0.1 1.7 2 0 0 2 2 2 0 Hypothetical protein FLILHELTA DUF5353 PF17304.2 PIK50525.1 - 0.087 12.6 1.8 0.16 11.7 1.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5353) DUF2768 PF10966.8 PIK50525.1 - 0.44 11.0 4.6 0.45 11.0 3.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2768) Cytochrom_B561 PF03188.16 PIK50526.1 - 2e-19 70.1 8.7 4.9e-19 68.8 8.2 2.0 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 Cation_ATPase_C PF00689.21 PIK50526.1 - 0.05 13.3 8.6 0.025 14.3 6.3 1.6 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF1461 PF07314.11 PIK50526.1 - 0.051 13.5 7.7 0.47 10.3 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1461) Ni_hydr_CYTB PF01292.20 PIK50526.1 - 0.093 12.3 16.8 0.02 14.5 6.3 2.8 1 1 2 3 3 3 0 Prokaryotic cytochrome b561 Integrin_beta PF00362.18 PIK50527.1 - 1.1e-98 329.8 0.0 1.5e-98 329.4 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 PIK50527.1 - 6e-18 64.3 0.1 1.2e-17 63.3 0.1 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 PIK50527.1 - 1.2e-17 64.2 5.3 1.2e-17 64.2 5.3 4.6 4 1 0 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.3 PIK50527.1 - 1.8e-12 46.8 6.9 1.8e-12 46.8 6.9 3.0 2 1 0 2 2 2 1 Integrin plexin domain I-EGF_1 PF18372.1 PIK50527.1 - 5.2e-07 29.6 21.6 1.7e-06 28.0 6.5 6.9 7 0 0 7 7 7 3 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 PIK50527.1 - 0.0035 17.7 11.7 0.0035 17.7 11.7 6.7 6 1 1 7 7 7 3 EGF-like domain DUF2975 PF11188.8 PIK50527.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) adh_short PF00106.25 PIK50528.1 - 2.3e-30 105.5 0.0 3.6e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK50528.1 - 9.7e-17 61.3 0.0 2.9e-16 59.7 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Lectin_C PF00059.21 PIK50528.1 - 8.8e-15 55.4 3.1 1.6e-14 54.6 3.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain KR PF08659.10 PIK50528.1 - 0.015 15.2 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 KR domain RINGv PF12906.7 PIK50529.1 - 6e-13 48.7 11.7 1.7e-12 47.2 11.7 1.9 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 PIK50529.1 - 1.3 9.4 13.3 0.57 10.6 10.1 2.1 2 0 0 2 2 2 0 Ring finger domain NUDIX PF00293.28 PIK50530.1 - 1.1e-24 86.9 0.1 1.6e-24 86.4 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain Cpn10 PF00166.21 PIK50531.1 - 0.047 13.7 0.1 0.18 11.9 0.1 2.0 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit GH3 PF03321.13 PIK50532.1 - 1e-53 183.0 0.0 1.3e-53 182.7 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter AMP-binding PF00501.28 PIK50532.1 - 0.0064 15.1 0.0 0.01 14.4 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme TatC PF00902.18 PIK50532.1 - 0.42 10.4 5.5 0.85 9.4 5.5 1.5 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) GH3 PF03321.13 PIK50533.1 - 5.5e-66 223.5 0.3 6.7e-66 223.2 0.3 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Integrin_beta PF00362.18 PIK50534.1 - 1.4e-55 188.6 5.1 5.8e-44 150.6 0.1 2.2 1 1 1 2 2 2 2 Integrin beta chain VWA domain I-EGF_1 PF18372.1 PIK50534.1 - 6.9e-10 38.8 3.9 6.9e-10 38.8 3.9 3.9 6 0 0 6 6 6 2 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 PIK50534.1 - 0.0035 17.7 10.2 0.0035 17.7 10.2 3.7 3 0 0 3 3 3 2 EGF-like domain HIP1_clath_bdg PF16515.5 PIK50535.1 - 3.3 8.4 31.2 7.6 7.2 7.9 3.4 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MMS22L_N PF14910.6 PIK50536.1 - 4.2e-69 233.8 22.4 7.9e-54 183.3 9.1 2.2 1 1 1 2 2 2 2 S-phase genomic integrity recombination mediator, N-terminal MMS22L_C PF14911.6 PIK50536.1 - 7.3e-37 127.3 3.8 7.3e-37 127.3 3.8 2.1 2 0 0 2 2 2 1 S-phase genomic integrity recombination mediator, C-terminal Mus7 PF09462.10 PIK50536.1 - 1.4e-05 24.2 5.4 0.012 14.5 0.1 3.3 4 0 0 4 4 4 2 Mus7/MMS22 family CRAL_TRIO_2 PF13716.6 PIK50536.1 - 0.084 13.0 1.0 1.9 8.6 0.1 3.1 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain LIP1 PF15904.5 PIK50536.1 - 0.23 11.8 1.7 6.6 7.1 0.0 3.4 3 0 0 3 3 3 0 LKB1 serine/threonine kinase interacting protein 1 Acyl-CoA_dh_1 PF00441.24 PIK50537.1 - 3.9e-53 179.7 2.0 5.7e-53 179.2 2.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK50537.1 - 2.5e-29 102.2 0.0 8e-29 100.6 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK50537.1 - 3.1e-27 95.5 0.6 5.8e-27 94.6 0.6 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK50537.1 - 3.5e-24 84.8 0.1 6e-24 84.1 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain DUF743 PF05332.11 PIK50537.1 - 0.013 15.5 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) fn3 PF00041.21 PIK50538.1 - 4.2e-22 78.3 12.3 1.4e-06 28.5 0.1 4.8 4 0 0 4 4 4 4 Fibronectin type III domain Glyco_hydro_36C PF16874.5 PIK50538.1 - 0.0022 18.4 0.0 1.6 9.3 0.0 3.5 3 0 0 3 3 3 1 Glycosyl hydrolase family 36 C-terminal domain DUF4381 PF14316.6 PIK50538.1 - 0.12 12.6 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) MarB PF13999.6 PIK50538.1 - 0.19 11.6 0.6 0.8 9.6 0.0 2.4 2 0 0 2 2 2 0 MarB protein DUF1410 PF07198.11 PIK50538.1 - 0.49 10.9 2.9 1.8 9.1 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1410) C8 PF08742.11 PIK50539.1 - 9.5e-17 61.2 2.3 9.5e-17 61.2 2.3 3.0 2 1 0 2 2 2 1 C8 domain VWD PF00094.25 PIK50539.1 - 1.5e-11 44.8 0.4 1.5e-11 44.8 0.4 1.8 2 0 0 2 2 2 1 von Willebrand factor type D domain TIL PF01826.17 PIK50539.1 - 3.1e-09 36.9 17.5 3.1e-09 36.9 17.5 3.2 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK50539.1 - 4.4e-05 23.3 5.9 4.4e-05 23.3 5.9 3.9 2 1 2 4 4 4 1 TILa domain VWD PF00094.25 PIK50540.1 - 0 1075.0 61.3 4.4e-35 121.3 1.9 11.3 11 0 0 11 11 11 11 von Willebrand factor type D domain C8 PF08742.11 PIK50540.1 - 5.2e-129 420.8 132.7 1.7e-18 66.8 2.1 15.8 14 0 0 14 14 14 10 C8 domain TILa PF12714.7 PIK50540.1 - 5.5e-77 253.6 326.5 4.4e-13 49.0 7.4 23.0 18 4 4 22 22 22 11 TILa domain TIL PF01826.17 PIK50540.1 - 3.9e-58 193.5 238.7 3.6e-10 39.9 18.5 32.2 25 11 5 30 30 30 10 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK50540.1 - 1.6e-13 50.6 65.7 6.6e-06 26.2 4.2 28.8 24 7 5 29 29 29 9 EGF domain S4 PF01479.25 PIK50540.1 - 6.1e-09 35.5 0.1 0.66 9.7 0.0 6.9 9 0 0 9 9 9 2 S4 domain EGF_MSP1_1 PF12946.7 PIK50540.1 - 0.0041 17.1 6.9 0.0041 17.1 6.9 23.4 24 0 0 24 24 24 6 MSP1 EGF domain 1 Ntox17 PF15524.6 PIK50540.1 - 0.48 10.8 3.8 39 4.6 0.0 4.6 5 0 0 5 5 5 0 Novel toxin 17 VWD PF00094.25 PIK50541.1 - 1.2e-46 158.9 10.7 1.7e-31 109.6 0.5 3.9 4 0 0 4 4 4 3 von Willebrand factor type D domain C8 PF08742.11 PIK50541.1 - 2.3e-28 98.4 9.4 8.2e-19 67.8 1.4 4.7 4 0 0 4 4 4 2 C8 domain TIL PF01826.17 PIK50541.1 - 6.9e-20 71.0 39.8 2.9e-11 43.5 14.3 7.6 7 2 1 8 8 8 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK50541.1 - 3.1e-12 46.2 16.0 3.1e-10 39.9 8.9 5.9 3 2 3 6 6 6 2 TILa domain EGF_3 PF12947.7 PIK50541.1 - 0.00017 21.7 6.5 0.00017 21.7 6.5 6.8 4 1 2 6 6 6 2 EGF domain Luciferase_N PF05295.11 PIK50541.1 - 0.01 15.8 0.1 2 8.5 0.0 3.0 3 0 0 3 3 3 0 Luciferase/LBP N-terminal domain cEGF PF12662.7 PIK50541.1 - 0.047 13.6 0.6 0.047 13.6 0.6 6.9 7 0 0 7 7 7 0 Complement Clr-like EGF-like VWD PF00094.25 PIK50542.1 - 1.5e-137 454.2 21.7 1.3e-36 126.3 0.3 6.5 5 1 1 6 6 6 6 von Willebrand factor type D domain C8 PF08742.11 PIK50542.1 - 2.8e-48 162.2 20.1 6.2e-19 68.2 3.5 10.8 10 2 2 12 12 12 3 C8 domain EGF PF00008.27 PIK50542.1 - 1.4e-38 130.8 314.4 1.3e-07 31.8 6.9 23.9 24 0 0 24 24 24 15 EGF-like domain TIL PF01826.17 PIK50542.1 - 3.2e-28 97.7 92.5 1.1e-11 44.8 19.1 20.6 10 4 3 13 13 13 4 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK50542.1 - 1.3e-17 63.5 55.4 1.8e-10 40.6 7.7 16.5 15 3 3 19 19 19 4 TILa domain hEGF PF12661.7 PIK50542.1 - 1.8e-06 28.4 32.1 2e-05 25.1 6.5 22.5 23 0 0 23 23 23 11 Human growth factor-like EGF fn3 PF00041.21 PIK50542.1 - 8.3e-06 26.1 2.7 0.0007 19.9 0.3 2.6 2 0 0 2 2 2 1 Fibronectin type III domain EGF_3 PF12947.7 PIK50542.1 - 0.00011 22.3 25.3 0.0008 19.6 6.4 24.9 22 2 2 25 25 25 8 EGF domain cEGF PF12662.7 PIK50542.1 - 0.002 18.0 8.1 0.002 18.0 8.1 21.9 24 1 0 24 24 24 5 Complement Clr-like EGF-like RXT2_N PF08595.11 PIK50542.1 - 1.7 8.7 6.8 3 7.9 6.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DRY_EERY PF09750.9 PIK50543.1 - 4.8e-28 98.1 0.4 4.8e-28 98.1 0.4 2.6 2 0 0 2 2 2 1 Alternative splicing regulator Surp PF01805.20 PIK50543.1 - 3e-22 78.3 1.8 1.1e-11 44.5 0.4 2.7 2 0 0 2 2 2 2 Surp module TPT PF03151.16 PIK50544.1 - 2.6e-38 132.0 24.9 3.3e-38 131.7 24.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 PIK50544.1 - 1.5e-11 44.6 36.9 2.5e-06 27.7 15.9 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 PIK50544.1 - 3.5e-10 39.6 27.1 4.4e-10 39.3 27.1 1.1 1 0 0 1 1 1 1 UAA transporter family Saf_2TM PF18303.1 PIK50544.1 - 0.89 9.1 9.1 0.059 12.9 3.2 2.2 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain Phage_glycop_gL PF11108.8 PIK50544.1 - 0.98 9.5 5.1 11 6.1 0.2 3.0 3 0 0 3 3 3 0 Viral glycoprotein L Sulfotransfer_3 PF13469.6 PIK50545.1 - 1.9e-06 28.4 0.0 6.8e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK50545.1 - 0.00088 18.8 0.1 0.0012 18.4 0.1 1.3 1 1 0 1 1 1 1 Sulfotransferase domain PUF PF00806.19 PIK50545.1 - 0.093 12.5 0.0 1.8 8.4 0.0 2.6 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Trypsin PF00089.26 PIK50546.1 - 1.2e-34 120.0 0.1 1.9e-34 119.4 0.1 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 PIK50546.1 - 1.5e-15 57.5 0.1 2.9e-15 56.5 0.1 1.5 1 0 0 1 1 1 1 CUB domain Trypsin_2 PF13365.6 PIK50546.1 - 1.7e-05 25.8 0.1 3.7e-05 24.7 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 PIK50546.1 - 0.0025 17.5 0.0 0.0047 16.5 0.0 1.4 1 0 0 1 1 1 1 Chymotrypsin family Peptidase-S1 Peptidase_M10 PF00413.24 PIK50547.1 - 2.8e-53 180.0 0.0 4.1e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK50547.1 - 4e-32 109.9 23.7 1.2e-09 38.0 0.2 4.6 5 0 0 5 5 5 4 Hemopexin Reprolysin_5 PF13688.6 PIK50547.1 - 0.0051 17.0 0.1 0.0084 16.3 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 PIK50547.1 - 0.013 15.1 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK50547.1 - 0.017 15.6 0.2 0.027 15.0 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK50547.1 - 0.035 13.3 0.1 0.07 12.3 0.1 1.4 1 0 0 1 1 1 0 Met-zincin Astacin PF01400.24 PIK50547.1 - 0.037 13.6 0.1 0.73 9.4 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Metallopep PF12044.8 PIK50547.1 - 0.047 12.3 0.0 0.072 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.9 PIK50547.1 - 0.13 11.2 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M54 PF07998.11 PIK50547.1 - 0.15 12.0 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M54 Death PF00531.22 PIK50548.1 - 7.2e-11 42.1 1.3 1.2e-10 41.3 1.3 1.3 1 0 0 1 1 1 1 Death domain CARD_2 PF16739.5 PIK50548.1 - 0.11 12.5 2.2 0.085 12.9 0.7 1.6 2 0 0 2 2 2 0 Caspase recruitment domain Pkinase PF00069.25 PIK50549.1 - 1.7e-75 253.8 0.1 2.1e-75 253.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50549.1 - 4.5e-44 150.7 0.0 5.8e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK50549.1 - 6.6e-10 38.8 0.0 9e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK50549.1 - 6e-06 25.4 0.1 9.4e-06 24.8 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK50549.1 - 0.0005 19.5 0.7 0.001 18.5 0.7 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 PIK50549.1 - 0.0036 16.9 0.2 0.0062 16.1 0.2 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 PIK50549.1 - 0.073 12.6 1.3 0.16 11.5 1.2 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase MRP-L27 PF09809.9 PIK50550.1 - 3.9e-21 75.0 0.0 1.2e-20 73.4 0.0 1.6 1 1 1 2 2 2 1 Mitochondrial ribosomal protein L27 JHY PF15261.6 PIK50551.1 - 1.3e-13 51.7 5.6 1.5e-13 51.6 5.6 1.0 1 0 0 1 1 1 1 Jhy protein KA1 PF02149.19 PIK50552.1 - 1.7e-13 50.1 0.0 3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Pkinase PF00069.25 PIK50553.1 - 0.03 13.7 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 PIK50554.1 - 9.4e-36 123.5 5.7 1.2e-35 123.1 5.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50554.1 - 8.8e-25 87.4 4.6 1.1e-24 87.2 4.6 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK50554.1 - 1.7e-06 27.5 0.4 2.4e-06 27.0 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK50554.1 - 3.2e-05 23.0 0.5 3.8e-05 22.8 0.5 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Glycos_transf_N PF04413.16 PIK50554.1 - 0.013 15.1 0.1 0.016 14.8 0.1 1.1 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) APH PF01636.23 PIK50554.1 - 0.042 13.8 0.3 0.061 13.2 0.2 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family UBD PF16455.5 PIK50554.1 - 0.047 13.9 0.0 0.062 13.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-binding domain Cytochrom_C1 PF02167.15 PIK50554.1 - 0.14 11.9 1.1 2.2 7.9 0.2 2.0 1 1 1 2 2 2 0 Cytochrome C1 family RVT_1 PF00078.27 PIK50556.1 - 8.3e-40 136.7 0.1 1.2e-39 136.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ER_lumen_recept PF00810.18 PIK50558.1 - 7.5e-38 130.6 1.1 7.5e-38 130.6 1.1 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 PIK50558.1 - 0.99 9.2 4.3 0.37 10.6 0.3 2.0 2 0 0 2 2 2 0 PQ loop repeat TPR_10 PF13374.6 PIK50559.1 - 0.036 13.9 1.4 4.4 7.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5338 PF17273.2 PIK50559.1 - 0.039 14.0 0.0 0.32 11.1 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5338) CLZ PF16526.5 PIK50559.1 - 0.38 11.1 3.6 5.1 7.5 0.8 2.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RT_RNaseH_2 PF17919.1 PIK50560.1 - 2e-29 101.6 0.0 3.7e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50560.1 - 7.4e-24 84.5 0.0 1.2e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK50560.1 - 2.4e-20 72.8 0.0 4.8e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 PIK50560.1 - 0.017 15.7 0.0 0.037 14.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK50560.1 - 0.079 13.6 0.0 0.26 12.0 0.0 1.9 1 1 0 1 1 1 0 Aspartyl protease rve PF00665.26 PIK50561.1 - 2.8e-17 63.0 0.0 7.7e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK50561.1 - 1.5e-14 53.8 3.1 5.8e-14 51.9 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain SapB_1 PF05184.15 PIK50561.1 - 0.016 15.2 0.1 0.039 14.0 0.1 1.7 1 0 0 1 1 1 0 Saposin-like type B, region 1 ERO1 PF04137.15 PIK50562.1 - 1.4e-75 254.7 0.0 1.7e-75 254.5 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CH PF00307.31 PIK50563.1 - 1.8e-11 44.1 0.1 4e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain SAM_2 PF07647.17 PIK50563.1 - 1.5e-06 28.2 0.0 3.5e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK50563.1 - 2.7e-05 24.5 0.0 0.00014 22.2 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) TMF_TATA_bd PF12325.8 PIK50563.1 - 0.078 13.2 4.0 2.9 8.1 0.7 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ion_trans_2 PF07885.16 PIK50565.1 - 1.6e-15 56.8 16.0 2.2e-13 50.0 10.2 2.4 2 1 0 2 2 2 2 Ion channel Ion_trans PF00520.31 PIK50565.1 - 0.011 15.0 2.1 0.018 14.3 2.1 1.4 1 0 0 1 1 1 0 Ion transport protein DUF2818 PF10993.8 PIK50565.1 - 0.022 15.3 0.4 0.053 14.1 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2818) AAA PF00004.29 PIK50566.1 - 4.1e-15 56.4 0.0 7.7e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK50566.1 - 0.00034 20.6 0.0 0.00075 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 PIK50566.1 - 0.00081 19.4 0.0 0.0027 17.6 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 PIK50566.1 - 0.00089 18.8 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 PIK50566.1 - 0.0014 19.0 0.1 0.023 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK50566.1 - 0.0025 18.1 0.1 0.011 16.0 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_lid_3 PF17862.1 PIK50566.1 - 0.0087 15.8 0.1 0.02 14.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_PrkA PF08298.11 PIK50566.1 - 0.0087 15.0 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain ABC_tran PF00005.27 PIK50566.1 - 0.01 16.3 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 PIK50566.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK50566.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 PIK50566.1 - 0.03 14.3 0.0 0.091 12.8 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 PIK50566.1 - 0.039 14.5 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 PIK50566.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_6 PF12774.7 PIK50566.1 - 0.15 11.0 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region RNase_PH PF01138.21 PIK50567.1 - 1.7e-37 128.8 0.0 2.2e-19 70.2 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK50567.1 - 2e-19 69.4 1.1 8.2e-13 48.2 0.0 3.2 3 0 0 3 3 3 2 3' exoribonuclease family, domain 2 PNPase PF03726.14 PIK50567.1 - 1.6e-08 35.0 2.4 1.7e-08 34.9 0.6 2.1 2 0 0 2 2 2 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 PIK50567.1 - 7.6e-06 25.7 0.0 1.7e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 KH domain S1 PF00575.23 PIK50567.1 - 0.00011 22.4 0.0 0.00037 20.8 0.0 2.0 1 0 0 1 1 1 1 S1 RNA binding domain RNase_E_G PF10150.9 PIK50567.1 - 0.077 12.4 0.7 0.13 11.7 0.7 1.2 1 0 0 1 1 1 0 Ribonuclease E/G family Latexin PF06907.12 PIK50568.1 - 0.12 11.9 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Latexin PP2C_2 PF13672.6 PIK50570.1 - 0.0056 16.4 1.6 2.5 7.7 0.0 3.0 3 0 0 3 3 3 1 Protein phosphatase 2C CHASE6_C PF17150.4 PIK50570.1 - 0.061 14.0 1.7 0.26 12.0 0.5 2.4 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain DivIC PF04977.15 PIK50570.1 - 0.14 12.0 3.1 4 7.3 1.3 2.5 2 0 0 2 2 2 0 Septum formation initiator Arg_tRNA_synt_N PF03485.16 PIK50570.1 - 0.15 12.7 2.4 0.16 12.6 0.5 2.1 2 0 0 2 2 2 0 Arginyl tRNA synthetase N terminal domain T3SSipB PF16535.5 PIK50570.1 - 0.5 10.8 7.2 3.3 8.2 0.1 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB FH2 PF02181.23 PIK50571.1 - 1e-74 252.0 22.4 2.1e-74 250.9 18.3 2.8 2 1 0 2 2 2 1 Formin Homology 2 Domain DUF2894 PF11445.8 PIK50571.1 - 0.04 14.4 0.7 0.18 12.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) ApoLp-III PF07464.11 PIK50571.1 - 7.3 6.7 10.7 0.24 11.5 1.2 2.9 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) p450 PF00067.22 PIK50573.1 - 1.6e-27 96.4 0.4 1.8e-27 96.2 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK50574.1 - 5.7e-53 180.3 0.0 7.7e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 ACC_central PF08326.12 PIK50574.1 - 0.047 11.9 0.1 0.071 11.3 0.1 1.2 1 0 0 1 1 1 0 Acetyl-CoA carboxylase, central region Pkinase PF00069.25 PIK50575.1 - 5.2e-19 68.6 0.0 2.6e-18 66.3 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50575.1 - 1.9e-15 56.9 0.0 7.6e-14 51.6 0.0 2.3 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK50575.1 - 0.0046 15.8 0.1 0.0061 15.4 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK50575.1 - 0.014 14.8 0.0 0.029 13.7 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK50575.1 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DSPc PF00782.20 PIK50576.1 - 1.3e-08 34.7 0.0 7.6e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Apocytochr_F_N PF16639.5 PIK50576.1 - 0.034 14.4 0.0 0.04 14.2 0.0 1.3 1 0 0 1 1 1 0 Apocytochrome F, N-terminal NHL PF01436.21 PIK50577.1 - 9.6e-12 44.3 3.2 5.3e-05 23.0 0.0 6.0 6 0 0 6 6 6 2 NHL repeat zf-C3HC4_2 PF13923.6 PIK50577.1 - 5.8e-10 38.8 9.6 1.3e-09 37.7 9.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK50577.1 - 2e-09 37.1 8.4 4.7e-09 36.0 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK50577.1 - 4.6e-09 36.2 6.0 9.4e-09 35.2 6.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK50577.1 - 1.5e-08 34.8 7.8 1.5e-08 34.8 7.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK50577.1 - 7.4e-08 32.1 7.9 1.1e-07 31.6 6.9 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK50577.1 - 2.3e-07 30.9 8.3 5.3e-07 29.7 8.3 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Filamin PF00630.19 PIK50577.1 - 1.7e-05 25.5 0.0 4.7e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-RING_5 PF14634.6 PIK50577.1 - 2.6e-05 24.1 6.5 7.2e-05 22.7 6.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain DUF5128 PF17170.4 PIK50577.1 - 0.00016 20.9 0.3 0.014 14.6 0.0 2.5 2 0 0 2 2 2 1 6-bladed beta-propeller Prok-RING_4 PF14447.6 PIK50577.1 - 0.00027 20.7 8.3 0.00027 20.7 8.3 2.2 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 Invasin_D3 PF09134.10 PIK50577.1 - 0.00029 21.1 0.3 0.0025 18.1 0.0 2.6 2 0 0 2 2 2 1 Invasin, domain 3 SBBP PF06739.11 PIK50577.1 - 0.0093 16.0 0.7 6.9 6.8 0.0 3.3 3 0 0 3 3 3 1 Beta-propeller repeat SdiA-regulated PF06977.11 PIK50577.1 - 0.023 13.9 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 SdiA-regulated HypA PF01155.19 PIK50577.1 - 0.25 11.4 2.2 0.55 10.3 2.2 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_17 PF17120.5 PIK50577.1 - 0.27 10.9 2.8 0.66 9.6 2.8 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 PIK50577.1 - 0.3 11.2 1.9 1.5 9.0 1.8 2.3 2 0 0 2 2 1 0 Zinc-binding RING-finger zf-rbx1 PF12678.7 PIK50577.1 - 0.61 10.4 9.3 4.1 7.8 9.4 2.3 1 1 1 2 2 2 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 PIK50577.1 - 2.3 8.2 6.3 9.1 6.4 6.3 1.9 1 1 0 1 1 1 0 zinc-ribbons NHL PF01436.21 PIK50578.1 - 1.8e-07 30.8 0.3 0.00011 22.0 0.0 4.2 4 0 0 4 4 4 1 NHL repeat Filamin PF00630.19 PIK50578.1 - 0.0037 18.0 0.0 0.0092 16.8 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF5128 PF17170.4 PIK50578.1 - 0.01 15.0 0.1 1 8.4 0.1 2.1 2 0 0 2 2 2 0 6-bladed beta-propeller SBBP PF06739.11 PIK50578.1 - 0.011 15.7 1.9 0.011 15.7 0.1 1.9 2 0 0 2 2 2 0 Beta-propeller repeat SGL PF08450.12 PIK50578.1 - 0.02 14.5 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 PIK50578.1 - 0.034 14.3 1.2 9.4 6.4 0.2 3.2 2 1 0 2 2 2 0 Strictosidine synthase NHL PF01436.21 PIK50579.1 - 9.4e-10 38.0 0.6 3.1e-06 27.0 0.0 3.4 3 0 0 3 3 3 2 NHL repeat SBBP PF06739.11 PIK50579.1 - 8.3e-07 28.9 0.1 0.007 16.3 0.0 2.6 2 0 0 2 2 2 2 Beta-propeller repeat SGL PF08450.12 PIK50579.1 - 0.0011 18.6 0.0 0.18 11.3 0.0 2.1 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region SdiA-regulated PF06977.11 PIK50579.1 - 0.009 15.3 0.0 2 7.6 0.0 2.4 3 0 0 3 3 3 2 SdiA-regulated DUF4073 PF13285.6 PIK50579.1 - 0.036 13.7 0.1 0.055 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) DUF5128 PF17170.4 PIK50579.1 - 0.052 12.7 0.0 0.077 12.1 0.0 1.3 1 1 0 1 1 1 0 6-bladed beta-propeller PhyH PF05721.13 PIK50580.1 - 6.3e-08 33.1 0.0 8.2e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) EntA_Immun PF08951.10 PIK50580.1 - 0.12 12.8 2.6 2.9 8.3 0.2 2.6 2 0 0 2 2 2 0 Enterocin A Immunity TSP_1 PF00090.19 PIK50581.1 - 1.8e-27 95.3 83.1 1.1e-09 38.4 8.0 7.6 8 0 0 8 8 7 5 Thrombospondin type 1 domain Reprolysin PF01421.19 PIK50581.1 - 1.8e-22 80.2 0.4 3.5e-22 79.3 0.4 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 PIK50581.1 - 1.1e-18 67.5 10.0 1.1e-18 67.5 10.0 7.0 6 3 1 7 7 5 2 ADAM cysteine-rich domain ADAM_spacer1 PF05986.14 PIK50581.1 - 8.6e-12 45.1 0.1 1.6e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin_3 PF13582.6 PIK50581.1 - 7.3e-10 39.4 0.8 1.6e-09 38.3 0.8 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK50581.1 - 5.7e-09 36.4 3.2 1.5e-08 35.0 3.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 PIK50581.1 - 6.8e-08 32.6 0.2 1.6e-07 31.4 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK50581.1 - 0.0013 18.4 0.1 0.0026 17.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like STOP PF05217.12 PIK50581.1 - 0.016 15.5 0.7 0.016 15.5 0.7 3.3 3 0 0 3 3 3 0 STOP protein PLAC PF08686.11 PIK50581.1 - 0.017 15.9 6.9 0.14 12.9 6.9 2.8 1 0 0 1 1 1 0 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 PIK50581.1 - 0.1 12.4 0.4 0.31 10.9 0.3 1.8 2 0 0 2 2 2 0 Matrixin Metallopep PF12044.8 PIK50581.1 - 4.6 5.8 7.0 14 4.2 2.7 2.2 2 0 0 2 2 2 0 Putative peptidase family AAA_18 PF13238.6 PIK50582.1 - 2.9e-29 102.2 0.0 4.7e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 PIK50582.1 - 1.6e-08 35.0 0.1 9.4e-08 32.6 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 PIK50582.1 - 2.8e-05 24.4 0.0 8.9e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 PIK50582.1 - 3.2e-05 24.1 0.5 0.00097 19.3 0.5 2.6 1 1 0 1 1 1 1 Shikimate kinase AAA_16 PF13191.6 PIK50582.1 - 0.00013 22.4 0.1 0.00028 21.3 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Cytidylate_kin2 PF13189.6 PIK50582.1 - 0.00015 22.0 0.0 0.00024 21.3 0.0 1.7 1 1 0 1 1 1 1 Cytidylate kinase-like family Cytidylate_kin PF02224.18 PIK50582.1 - 0.00021 21.1 0.0 0.00045 20.0 0.0 1.6 2 0 0 2 2 2 1 Cytidylate kinase AAA_22 PF13401.6 PIK50582.1 - 0.00029 21.1 0.0 0.00067 20.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 PIK50582.1 - 0.00041 20.5 0.1 0.0046 17.1 0.0 2.2 1 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 PIK50582.1 - 0.00062 19.6 0.0 0.00093 19.0 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 PIK50582.1 - 0.00066 20.1 0.0 0.0017 18.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK50582.1 - 0.0012 18.9 0.1 0.011 15.8 0.0 2.0 1 1 1 2 2 2 1 AAA domain dNK PF01712.19 PIK50582.1 - 0.0012 18.7 2.4 0.33 10.8 0.2 2.4 2 1 0 2 2 2 2 Deoxynucleoside kinase KTI12 PF08433.10 PIK50582.1 - 0.0012 18.3 0.0 0.003 17.0 0.0 1.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_5 PF07728.14 PIK50582.1 - 0.0016 18.5 0.1 0.0055 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 PIK50582.1 - 0.0025 17.7 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 NTPase DUF2075 PF09848.9 PIK50582.1 - 0.0041 16.4 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 PIK50582.1 - 0.0051 17.2 0.0 0.012 16.0 0.0 1.7 2 0 0 2 2 1 1 RNA helicase ADK PF00406.22 PIK50582.1 - 0.0057 16.8 0.0 0.023 14.8 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase ATPase PF06745.13 PIK50582.1 - 0.0062 15.9 0.2 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 KaiC Zeta_toxin PF06414.12 PIK50582.1 - 0.0086 15.4 0.4 0.61 9.3 0.0 2.6 2 1 1 3 3 3 1 Zeta toxin DUF815 PF05673.13 PIK50582.1 - 0.017 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 PIK50582.1 - 0.017 14.8 0.2 0.032 14.0 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 PIK50582.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 PIK50582.1 - 0.029 13.4 0.1 0.074 12.0 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 PIK50582.1 - 0.03 13.7 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 PIK50582.1 - 0.044 13.7 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 PIK50582.1 - 0.081 12.9 0.0 0.099 12.6 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 PIK50582.1 - 0.089 12.3 0.4 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 PIK50582.1 - 0.09 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 PIK50582.1 - 0.097 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ribosomal_S3Ae PF01015.18 PIK50582.1 - 0.11 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal S3Ae family MMR_HSR1 PF01926.23 PIK50582.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ploopntkinase3 PF18751.1 PIK50582.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 MCM PF00493.23 PIK50582.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_30 PF13604.6 PIK50582.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 PIK50582.1 - 0.16 11.0 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 PIK50582.1 - 0.19 11.3 0.1 0.41 10.2 0.1 1.5 1 1 0 1 1 1 0 AAA domain Bcr-Abl_Oligo PF09036.10 PIK50582.1 - 0.42 10.7 2.3 1.5 8.8 0.2 2.6 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain 7tm_1 PF00001.21 PIK50583.1 - 9e-43 146.5 12.6 1.2e-42 146.1 12.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK50583.1 - 2.8e-09 36.7 14.0 3.8e-09 36.3 14.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK50583.1 - 0.004 16.8 18.2 0.0062 16.2 17.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1907 PF08925.11 PIK50583.1 - 0.09 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) DUF5514 PF17633.2 PIK50584.1 - 3.7e-06 27.2 0.5 8.2 6.7 0.0 4.2 4 0 0 4 4 4 1 Family of unknown function (DUF5514) Phage_HK97_TLTM PF06120.11 PIK50584.1 - 1.2e-05 24.6 0.3 3.4 6.8 0.0 4.0 4 0 0 4 4 4 2 Tail length tape measure protein Gly_acyl_tr_C PF08444.10 PIK50584.1 - 4.8e-05 23.5 0.2 27 5.1 0.0 5.1 4 0 0 4 4 4 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Img2 PF05046.14 PIK50584.1 - 0.0017 18.6 5.3 12 6.3 0.0 6.4 5 2 2 7 7 7 1 Mitochondrial large subunit ribosomal protein (Img2) THF_DHG_CYH_C PF02882.19 PIK50584.1 - 0.002 17.4 3.0 21 4.4 0.1 4.2 4 0 0 4 4 4 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2067 PF09840.9 PIK50584.1 - 0.0048 16.5 0.0 67 3.0 0.0 4.2 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2067) DUF551 PF04448.12 PIK50584.1 - 0.016 16.1 0.1 28 5.7 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF551) Herpes_UL37_2 PF07413.11 PIK50584.1 - 0.029 13.6 0.0 12 5.0 0.0 2.9 1 1 2 3 3 3 0 Betaherpesvirus immediate-early glycoprotein UL37 NETI PF14044.6 PIK50584.1 - 0.053 13.3 0.1 87 3.0 0.0 5.0 6 0 0 6 6 6 0 NETI protein F_actin_bind PF08919.10 PIK50584.1 - 0.19 11.8 0.0 52 4.0 0.0 3.2 3 0 0 3 3 3 0 F-actin binding GKAP PF03359.13 PIK50585.1 - 5.2e-28 98.6 4.1 5.2e-28 98.6 4.1 1.5 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein NPIP PF06409.11 PIK50585.1 - 0.0011 18.1 2.8 0.0019 17.3 2.8 1.4 1 0 0 1 1 1 1 Nuclear pore complex interacting protein (NPIP) Caudo_TAP PF02413.17 PIK50585.1 - 0.5 10.5 4.0 0.96 9.6 2.6 2.0 2 0 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK Cas_Csy4 PF09618.10 PIK50585.1 - 1.3 9.1 6.5 1.4 9.0 1.5 2.3 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Uso1_p115_C PF04871.13 PIK50585.1 - 1.9 8.9 11.0 2 8.8 4.5 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region UQ_con PF00179.26 PIK50587.1 - 7.8e-36 122.8 0.4 8.4e-36 122.7 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK50587.1 - 0.028 14.3 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 UEV domain UFC1 PF08694.11 PIK50587.1 - 0.037 13.7 0.0 0.058 13.0 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 PIK50587.1 - 0.053 13.8 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_A PF14457.6 PIK50587.1 - 0.081 12.6 0.2 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family A Secretin PF00263.21 PIK50587.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial type II and III secretion system protein Ion_trans PF00520.31 PIK50588.1 - 5.2e-52 176.5 12.4 6.4e-52 176.2 12.4 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK50588.1 - 9e-12 44.8 7.5 9e-12 44.8 7.5 2.2 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 PIK50588.1 - 0.0031 16.3 4.2 0.0054 15.5 4.2 1.3 1 0 0 1 1 1 1 Polycystin cation channel PGPGW PF09656.10 PIK50588.1 - 2.2 7.9 7.7 1 9.0 3.7 2.2 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) DUF4212 PF13937.6 PIK50588.1 - 5.2 7.5 10.1 0.66 10.4 1.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) CLCA PF08434.11 PIK50589.1 - 5.2e-76 255.5 0.0 8.3e-76 254.8 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK50589.1 - 6e-15 55.9 1.0 1.4e-14 54.7 1.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK50589.1 - 1.3e-13 51.6 0.3 3.1e-13 50.3 0.3 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK50589.1 - 1.8e-05 24.2 0.1 4.1e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Neur_chan_LBD PF02931.23 PIK50590.1 - 7.1e-28 97.5 0.3 7.1e-28 97.5 0.3 1.6 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK50590.1 - 1.3e-24 87.6 0.8 2e-24 87.0 0.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Transmemb_17 PF09799.9 PIK50590.1 - 0.051 14.2 0.9 0.051 14.2 0.9 2.0 2 0 0 2 2 2 0 Predicted membrane protein TMEM192 PF14802.6 PIK50590.1 - 0.1 11.7 3.4 0.55 9.3 0.0 2.5 3 0 0 3 3 3 0 TMEM192 family DUF4006 PF13179.6 PIK50590.1 - 0.24 11.4 0.2 0.24 11.4 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF4006) TMEM132D_C PF15706.5 PIK50590.1 - 2.7 7.8 4.4 1.2 9.0 1.3 2.1 2 1 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term BTB PF00651.31 PIK50591.1 - 2.8e-37 127.4 8.1 1.5e-23 83.2 0.6 3.5 4 0 0 4 4 4 2 BTB/POZ domain Kelch_1 PF01344.25 PIK50591.1 - 5e-32 109.2 12.3 5.3e-07 29.1 0.0 6.7 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 PIK50591.1 - 1e-25 89.8 0.1 6.9e-25 87.1 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 PIK50591.1 - 9.7e-23 79.6 2.6 0.00057 20.1 0.0 6.4 4 1 2 6 6 6 5 Kelch motif Kelch_4 PF13418.6 PIK50591.1 - 3.2e-14 52.6 0.4 0.018 15.1 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK50591.1 - 3.2e-13 49.6 2.2 0.0075 16.5 0.0 5.9 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK50591.1 - 5.5e-08 32.5 5.2 1.8 8.7 0.0 5.8 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 PIK50591.1 - 2.3e-05 24.3 3.2 5.7 7.0 0.0 4.4 4 0 0 4 4 4 1 Kelch motif DUF3342 PF11822.8 PIK50591.1 - 6.1e-05 23.1 0.4 0.15 12.3 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF3342) LcrG PF07216.12 PIK50591.1 - 0.084 12.8 0.7 0.18 11.7 0.1 1.8 2 0 0 2 2 2 0 LcrG protein Strumpellin PF10266.9 PIK50592.1 - 7.2e-32 110.1 1.6 8e-32 110.0 1.6 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Strumpellin PF10266.9 PIK50593.1 - 0 1225.0 20.0 0 1136.9 16.2 3.0 2 1 0 2 2 2 2 Hereditary spastic paraplegia protein strumpellin Phytochelatin PF05023.14 PIK50594.1 - 1.7e-43 148.4 0.0 2.1e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase Peptidase_C39_2 PF13529.6 PIK50594.1 - 0.0045 17.5 0.1 0.008 16.7 0.1 1.4 1 1 0 1 1 1 1 Peptidase_C39 like family PUA_2 PF14306.6 PIK50594.1 - 0.074 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 PUA-like domain GTP_EFTU PF00009.27 PIK50595.1 - 7e-13 48.6 0.2 3.3e-12 46.4 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 PIK50595.1 - 1.8e-12 47.4 0.1 5.5e-12 45.8 0.0 1.9 2 0 0 2 2 2 1 HBS1 N-terminus AAA_22 PF13401.6 PIK50595.1 - 0.0034 17.7 0.1 0.011 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 PIK50595.1 - 0.018 15.1 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 PIK50595.1 - 0.19 11.5 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 PIK50596.1 - 2.3e-25 89.3 0.0 4.4e-25 88.4 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 PIK50596.1 - 9.5e-14 51.7 0.4 2.4e-13 50.3 0.2 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 PIK50596.1 - 5.5e-06 26.7 0.9 1.3e-05 25.4 1.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Plexin_cytopl PF08337.12 PIK50596.1 - 0.083 11.6 0.0 6.1 5.4 0.0 2.0 2 0 0 2 2 2 0 Plexin cytoplasmic RasGAP domain Sulfotransfer_2 PF03567.14 PIK50597.1 - 1.9e-41 142.7 0.8 2.6e-41 142.2 0.8 1.2 1 0 0 1 1 1 1 Sulfotransferase family TBK1_CCD1 PF18394.1 PIK50597.1 - 0.013 15.1 0.1 0.9 9.0 0.0 2.4 1 1 1 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 CUB PF00431.20 PIK50598.1 - 1.4e-24 86.6 0.0 3.7e-24 85.2 0.0 1.8 1 0 0 1 1 1 1 CUB domain CD225 PF04505.12 PIK50598.1 - 0.07 13.3 1.4 0.15 12.2 1.4 1.5 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Cadherin_C_2 PF16492.5 PIK50598.1 - 0.078 13.7 0.8 0.3 11.8 0.8 2.2 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Shisa PF13908.6 PIK50598.1 - 0.09 13.0 0.2 0.09 13.0 0.2 3.4 3 1 1 4 4 4 0 Wnt and FGF inhibitory regulator GST_C PF00043.25 PIK50599.1 - 3.4e-06 27.2 0.1 7.2e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK50599.1 - 3e-05 24.1 0.4 8.5e-05 22.7 0.3 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RTP1_C1 PF10363.9 PIK50600.1 - 3e-34 117.5 3.8 1e-33 115.9 0.2 3.1 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 PIK50600.1 - 2.9e-05 24.4 1.0 0.011 16.3 0.0 3.9 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 PIK50600.1 - 3.4e-05 23.7 7.6 0.034 14.4 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 PIK50600.1 - 5.2e-05 23.5 1.8 0.06 13.7 0.1 3.7 3 0 0 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 PIK50600.1 - 0.00041 20.9 0.1 0.045 14.3 0.0 2.8 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region RTP1_C2 PF10304.9 PIK50600.1 - 0.00041 20.0 2.3 0.00041 20.0 2.3 2.7 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 ParcG PF10274.9 PIK50600.1 - 0.0082 16.3 0.8 0.17 12.0 0.0 2.4 2 0 0 2 2 2 1 Parkin co-regulated protein Cnd1 PF12717.7 PIK50600.1 - 0.011 15.8 6.1 0.029 14.4 0.0 3.4 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 PIK50600.1 - 0.015 15.2 1.0 3.2 7.7 0.0 3.4 3 0 0 3 3 3 0 UME (NUC010) domain C1_1 PF00130.22 PIK50601.1 - 4.2e-21 74.6 16.5 1.8e-17 63.0 7.3 2.1 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) FAM150 PF15129.6 PIK50601.1 - 0.026 14.7 0.9 0.04 14.1 0.9 1.3 1 0 0 1 1 1 0 FAM150 family C1_2 PF03107.16 PIK50601.1 - 0.21 11.9 14.9 0.064 13.6 6.8 2.4 2 0 0 2 2 2 0 C1 domain FYVE_2 PF02318.16 PIK50601.1 - 2 8.7 6.2 0.51 10.6 3.0 1.7 1 1 1 2 2 2 0 FYVE-type zinc finger PHD PF00628.29 PIK50601.1 - 2.7 8.0 16.4 0.68 9.9 7.8 2.7 2 1 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.6 PIK50601.1 - 4.5 7.2 12.0 0.82 9.6 4.7 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Pkinase PF00069.25 PIK50602.1 - 9.9e-64 215.2 0.0 2.3e-63 214.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50602.1 - 1.3e-38 132.8 0.0 2.3e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 PIK50602.1 - 9.8e-24 83.6 0.1 2e-23 82.6 0.1 1.6 1 0 0 1 1 1 1 C2 domain Haspin_kinase PF12330.8 PIK50602.1 - 0.00086 18.3 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK50602.1 - 0.0028 17.0 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 PIK50602.1 - 0.0044 17.7 0.9 0.014 16.1 0.9 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 PIK50602.1 - 0.059 13.0 0.1 2 8.0 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 PIK50602.1 - 0.16 11.9 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_8 PF13855.6 PIK50604.1 - 1.9e-15 56.4 12.4 8.1e-11 41.5 4.5 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK50604.1 - 7.8e-09 35.7 21.3 2.4e-06 27.8 3.8 3.6 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK50604.1 - 0.00037 20.6 12.3 0.22 12.2 0.0 4.7 4 1 0 4 4 4 2 Leucine Rich Repeat LRRNT PF01462.18 PIK50604.1 - 0.021 14.5 0.7 0.063 13.0 0.7 1.9 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 PIK50604.1 - 0.038 14.0 0.2 0.089 12.7 0.2 1.6 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK50604.1 - 0.038 13.5 5.5 0.1 12.1 4.4 1.6 1 1 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 PIK50604.1 - 1.1 9.5 9.9 1.4 9.2 0.1 3.6 4 0 0 4 4 4 0 Leucine Rich repeat Fascin PF06268.13 PIK50605.1 - 7.9e-32 109.8 0.1 5e-12 46.0 0.0 3.1 3 0 0 3 3 3 3 Fascin domain FRG1 PF06229.12 PIK50605.1 - 3.4e-08 33.4 0.0 0.0013 18.4 0.0 3.1 2 1 1 3 3 3 2 FRG1-like domain RUN PF02759.19 PIK50606.1 - 7.4e-18 64.8 0.3 1.1e-17 64.2 0.3 1.3 1 0 0 1 1 1 1 RUN domain PDZ_6 PF17820.1 PIK50606.1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 PDZ domain PBCV_basic_adap PF08789.10 PIK50606.1 - 0.29 11.3 2.5 0.44 10.7 0.2 2.4 3 0 0 3 3 3 0 PBCV-specific basic adaptor domain FtsJ PF01728.19 PIK50607.1 - 4.9e-23 82.1 0.0 5.4e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase FtsJ PF01728.19 PIK50608.1 - 7.2e-18 65.3 0.0 8e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase CUB PF00431.20 PIK50609.1 - 1.9e-20 73.3 0.1 4.9e-20 71.9 0.1 1.7 2 0 0 2 2 2 1 CUB domain UT PF03253.14 PIK50609.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Urea transporter LapA_dom PF06305.11 PIK50609.1 - 1.1 9.2 4.6 0.34 10.8 0.5 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Trypsin PF00089.26 PIK50610.1 - 1.2e-27 97.2 0.2 1.7e-27 96.7 0.2 1.2 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK50610.1 - 2.5e-09 37.2 11.0 2.5e-09 37.2 11.0 1.9 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Trypsin PF00089.26 PIK50611.1 - 2e-38 132.5 0.0 2.5e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK50611.1 - 0.00026 21.4 0.1 0.00042 20.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK50611.1 - 0.00065 20.6 0.0 0.00089 20.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ion_trans PF00520.31 PIK50612.1 - 1.4e-29 103.1 29.0 2.6e-23 82.5 20.4 2.2 2 0 0 2 2 2 2 Ion transport protein ATP-synt_8 PF00895.20 PIK50612.1 - 0.24 11.9 2.4 1.4 9.4 0.1 2.9 2 0 0 2 2 2 0 ATP synthase protein 8 IQ PF00612.27 PIK50613.1 - 0.00017 21.1 0.7 0.00042 19.8 0.7 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif CLZ PF16526.5 PIK50613.1 - 0.0071 16.7 6.6 0.0071 16.7 6.6 4.7 5 1 0 5 5 5 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PSII_Pbs27 PF13326.6 PIK50613.1 - 0.76 10.1 9.2 6.4 7.1 8.8 2.5 1 1 0 1 1 1 0 Photosystem II Pbs27 Img2 PF05046.14 PIK50613.1 - 2.9 8.2 5.3 25 5.3 1.6 3.5 2 1 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) T-box PF00907.22 PIK50615.1 - 1.7e-79 266.4 0.0 2.3e-79 265.9 0.0 1.2 1 0 0 1 1 1 1 T-box Hemopexin PF00045.19 PIK50616.1 - 1.3e-43 146.7 9.9 3.5e-14 52.5 1.3 4.3 4 0 0 4 4 4 4 Hemopexin Peptidase_M10 PF00413.24 PIK50616.1 - 3.4e-09 36.7 0.1 1.2e-06 28.5 0.1 2.5 2 0 0 2 2 2 2 Matrixin Sulfotransfer_2 PF03567.14 PIK50617.1 - 2.1e-41 142.5 3.1 2.5e-41 142.3 3.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family ABC_membrane PF00664.23 PIK50618.1 - 1.3e-60 205.3 16.8 1.5e-60 205.2 15.4 1.7 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_membrane_3 PF13748.6 PIK50618.1 - 3.7e-05 23.1 6.8 3.7e-05 23.1 6.8 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region MENTAL PF10457.9 PIK50618.1 - 0.0094 15.8 1.2 0.027 14.3 1.2 1.8 1 0 0 1 1 1 1 Cholesterol-capturing domain Pico_P2B PF01552.17 PIK50618.1 - 0.099 12.8 0.2 0.27 11.4 0.2 1.8 1 0 0 1 1 1 0 Picornavirus 2B protein DUF3671 PF12420.8 PIK50618.1 - 5.9 7.0 5.7 29 4.8 0.6 3.4 3 1 1 4 4 4 0 Protein of unknown function ABC_tran PF00005.27 PIK50619.1 - 2.5e-17 63.7 0.0 4.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK50619.1 - 5.8e-06 25.9 0.1 8.1e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain UPF0728 PF15092.6 PIK50619.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0728 SbcCD_C PF13558.6 PIK50619.1 - 0.079 13.2 1.0 1.2 9.4 1.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ETAA1 PF15350.6 PIK50621.1 - 0.34 9.2 13.2 0.041 12.2 9.3 1.4 2 0 0 2 2 2 0 Ewing's tumour-associated antigen 1 homologue YscO-like PF16789.5 PIK50621.1 - 4.4 7.3 10.2 2.8 7.9 7.4 1.8 2 0 0 2 2 2 0 YscO-like protein Zip PF02535.22 PIK50621.1 - 7.8 5.6 7.8 5.2 6.2 1.6 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Rrp40_N PF18311.1 PIK50622.1 - 4.9 7.2 8.8 0.24 11.4 2.3 1.9 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain DUF2249 PF10006.9 PIK50623.1 - 0.00011 22.0 18.6 6.2 6.8 0.2 5.9 1 1 8 9 9 9 9 Uncharacterized conserved protein (DUF2249) Alpha-amyl_C2 PF07821.12 PIK50623.1 - 1.1 9.5 18.4 16 5.9 2.7 5.0 1 1 3 4 4 4 0 Alpha-amylase C-terminal beta-sheet domain Peptidase_M10 PF00413.24 PIK50624.1 - 1.6e-31 109.3 0.0 2.5e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 PIK50624.1 - 3.2e-09 36.9 0.0 9.6e-09 35.3 0.0 1.8 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Hemopexin PF00045.19 PIK50624.1 - 1.6e-08 34.4 0.4 0.00067 19.6 0.0 3.4 3 0 0 3 3 3 2 Hemopexin Reprolysin_3 PF13582.6 PIK50624.1 - 0.00024 21.6 0.0 0.00049 20.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK50624.1 - 0.00064 19.9 0.1 0.0011 19.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 PIK50624.1 - 0.00076 19.2 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 PIK50624.1 - 0.0075 14.9 0.1 0.011 14.4 0.1 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_2 PF13574.6 PIK50624.1 - 0.012 15.5 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 PIK50624.1 - 0.014 15.0 0.2 0.22 11.1 0.2 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M43 PF05572.13 PIK50624.1 - 0.03 14.2 0.0 0.099 12.6 0.0 1.9 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A Peptidase_M54 PF07998.11 PIK50624.1 - 0.074 13.0 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M57 PF12388.8 PIK50624.1 - 0.15 11.6 1.9 0.82 9.2 1.6 2.0 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase Peptidase_M48 PF01435.18 PIK50624.1 - 0.21 11.4 0.1 0.35 10.6 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M48 MMS19_N PF14500.6 PIK50624.1 - 0.28 10.7 0.1 0.42 10.1 0.1 1.2 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF4953 PF16313.5 PIK50624.1 - 0.42 9.8 2.9 0.23 10.6 0.6 1.6 2 0 0 2 2 2 0 Met-zincin DHHC PF01529.20 PIK50625.1 - 4.9e-38 130.3 13.9 7.4e-38 129.7 13.9 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase EpsG PF14897.6 PIK50625.1 - 0.00095 18.6 0.9 0.0013 18.1 0.9 1.1 1 0 0 1 1 1 1 EpsG family CitMHS PF03600.16 PIK50625.1 - 0.17 11.0 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter Mito_fiss_reg PF05308.11 PIK50625.1 - 0.24 11.5 7.3 0.47 10.5 7.3 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF908 PF06012.12 PIK50625.1 - 0.81 9.0 10.3 1.1 8.6 10.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FXMRP1_C_core PF12235.8 PIK50625.1 - 1.5 9.5 6.3 2.8 8.6 5.7 1.8 1 1 0 1 1 1 0 Fragile X-related 1 protein core C terminal Phosphonate-bd PF12974.7 PIK50627.1 - 1.5e-26 93.5 0.0 1.9e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 PIK50627.1 - 0.0082 15.6 0.0 0.018 14.5 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Adaptin_N PF01602.20 PIK50628.1 - 9.1e-158 526.1 14.2 1.2e-157 525.7 14.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 PIK50628.1 - 1.9e-66 223.1 9.5 7.8e-64 214.6 0.5 3.1 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 PIK50628.1 - 2.3e-28 98.5 0.1 6.3e-28 97.1 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 PIK50628.1 - 3.3e-19 69.0 2.3 3.8e-07 30.4 0.0 6.3 2 2 5 7 7 7 4 HEAT repeats HEAT PF02985.22 PIK50628.1 - 2.2e-09 36.7 9.2 0.18 12.1 0.0 7.1 7 0 0 7 7 7 3 HEAT repeat Arm PF00514.23 PIK50628.1 - 4.4e-09 36.1 2.3 0.0095 16.0 0.0 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd3 PF12719.7 PIK50628.1 - 3.2e-07 29.8 2.6 9.2e-06 25.1 0.2 2.9 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 PIK50628.1 - 9.1e-06 25.4 1.8 0.0075 15.9 0.2 3.4 2 2 2 4 4 4 2 CLASP N terminal RTP1_C1 PF10363.9 PIK50628.1 - 0.00033 20.8 4.8 4.4 7.5 0.0 5.2 1 1 4 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 PIK50628.1 - 0.0095 15.8 2.9 0.026 14.4 0.1 3.1 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3453 PF11935.8 PIK50628.1 - 0.033 13.8 1.4 2.2 7.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3453) HEAT_EZ PF13513.6 PIK50628.1 - 0.12 12.9 5.6 44 4.7 0.0 5.7 5 2 1 6 6 5 0 HEAT-like repeat DUF5578 PF17741.1 PIK50628.1 - 0.79 9.1 5.9 8.7 5.7 0.1 4.0 2 2 2 5 5 5 0 Family of unknown function (DUF5578) adh_short PF00106.25 PIK50629.1 - 1.2e-40 139.1 0.0 1.5e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK50629.1 - 2.8e-39 135.1 0.0 3.4e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK50629.1 - 1.1e-07 32.0 0.1 1.6e-07 31.4 0.1 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK50629.1 - 0.0027 17.2 0.0 0.033 13.7 0.0 2.5 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK50629.1 - 0.019 14.4 0.0 0.1 11.9 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 PIK50629.1 - 0.033 13.3 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Octopine_DH PF02317.17 PIK50629.1 - 0.14 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain adh_short PF00106.25 PIK50630.1 - 4.4e-49 166.6 0.3 5.3e-49 166.3 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK50630.1 - 4.1e-39 134.5 0.0 5.2e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK50630.1 - 1.3e-12 48.0 0.2 1.9e-12 47.4 0.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 PIK50630.1 - 4.9e-05 23.3 0.0 6.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 PIK50630.1 - 0.00056 20.2 0.1 0.0011 19.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 PIK50630.1 - 0.0016 17.9 0.2 0.0024 17.3 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 PIK50630.1 - 0.0032 16.6 0.2 0.0043 16.2 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK50630.1 - 0.0055 16.2 0.1 0.011 15.2 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 PIK50630.1 - 0.022 15.3 0.1 0.046 14.3 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 PIK50630.1 - 0.035 13.1 0.5 0.059 12.4 0.5 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 PIK50630.1 - 0.044 13.8 0.1 0.086 12.9 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_transf_10 PF00852.19 PIK50632.1 - 7e-42 143.1 3.2 1.2e-41 142.4 3.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK50632.1 - 5.2e-08 33.3 1.0 2e-07 31.4 0.3 2.3 1 1 1 2 2 2 1 Fucosyltransferase, N-terminal VWD PF00094.25 PIK50633.1 - 6.1e-90 299.6 0.4 1.3e-31 110.0 0.6 3.2 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 PIK50633.1 - 3.5e-28 97.8 24.0 8.2e-13 48.6 2.1 6.9 7 0 0 7 7 7 3 C8 domain TIL PF01826.17 PIK50633.1 - 4.9e-26 90.7 70.5 1.5e-11 44.3 18.8 10.0 8 4 2 10 10 10 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK50633.1 - 6.5e-22 77.2 93.1 6.4e-12 45.2 9.6 7.9 7 0 0 7 7 7 3 TILa domain EGF_MSP1_1 PF12946.7 PIK50633.1 - 2.2e-05 24.4 8.2 2.2e-05 24.4 8.2 6.8 8 0 0 8 8 8 3 MSP1 EGF domain 1 EGF_3 PF12947.7 PIK50633.1 - 0.00016 21.8 6.4 0.00016 21.8 6.4 8.6 8 0 0 8 8 8 3 EGF domain DUF1521 PF07481.11 PIK50633.1 - 0.0019 18.2 0.3 1.8 8.5 0.0 2.8 3 0 0 3 3 3 2 Domain of Unknown Function (DUF1521) TILa PF12714.7 PIK50634.1 - 1.7e-15 56.7 45.2 1.6e-08 34.4 9.3 4.2 2 1 1 3 3 3 2 TILa domain Methyltransf_FA PF12248.8 PIK50634.1 - 7.2e-15 55.2 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase Lectin_C PF00059.21 PIK50634.1 - 3.6e-10 40.5 1.4 0.00013 22.7 0.0 3.0 3 0 0 3 3 3 2 Lectin C-type domain TIL PF01826.17 PIK50634.1 - 5.8e-09 36.1 13.4 5.8e-09 36.1 13.4 5.4 3 2 2 5 5 5 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK50634.1 - 9.5e-07 28.9 29.3 0.00017 21.7 10.5 5.1 5 0 0 5 5 5 2 EGF domain EGF_MSP1_1 PF12946.7 PIK50634.1 - 5.9e-05 23.0 22.7 0.00017 21.6 8.7 5.3 6 0 0 6 6 6 2 MSP1 EGF domain 1 HYR PF02494.16 PIK50634.1 - 0.00076 19.8 0.0 0.0018 18.6 0.0 1.6 1 0 0 1 1 1 1 HYR domain TPH PF13868.6 PIK50635.1 - 1.8e-15 56.3 142.4 1.8e-15 56.3 142.4 2.2 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain Lectin_C PF00059.21 PIK50636.1 - 2.4e-05 25.0 2.9 5e-05 24.0 2.6 1.7 2 0 0 2 2 2 1 Lectin C-type domain EamA PF00892.20 PIK50637.1 - 2.2e-20 73.2 32.2 1.3e-17 64.2 6.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK50637.1 - 0.0038 16.6 11.2 0.019 14.3 0.1 2.6 2 1 1 3 3 3 2 Triose-phosphate Transporter family Collagen PF01391.18 PIK50638.1 - 5.1e-24 83.8 87.0 2.8e-10 39.8 29.6 3.5 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK50639.1 - 1.4e-112 367.5 419.0 6.4e-09 35.4 19.4 16.5 2 2 12 14 14 14 14 Collagen triple helix repeat (20 copies) COLFI PF01410.18 PIK50639.1 - 8.2e-53 179.1 0.0 1.1e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain DNA_methylase PF00145.17 PIK50640.1 - 2.2e-15 56.8 0.2 3e-15 56.4 0.0 1.3 2 0 0 2 2 2 1 C-5 cytosine-specific DNA methylase DNA_methylase PF00145.17 PIK50641.1 - 3.3e-30 105.6 0.0 4e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 PIK50642.1 - 1.9e-39 134.3 1.0 7.2e-19 67.8 0.2 2.6 2 0 0 2 2 2 2 BAH domain DNMT1-RFD PF12047.8 PIK50643.1 - 7.2e-43 146.1 0.0 7.2e-43 146.1 0.0 2.0 2 1 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain CDC27 PF09507.10 PIK50643.1 - 0.85 8.9 28.3 1.1 8.5 28.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Red1 PF07964.11 PIK50643.1 - 7.4 4.7 22.9 10 4.2 22.9 1.1 1 0 0 1 1 1 0 Rec10 / Red1 DMAP_binding PF06464.11 PIK50644.1 - 6.8e-25 88.0 2.7 1.1e-11 45.4 0.0 2.1 1 1 1 2 2 2 2 DMAP1-binding Domain GvpG PF05120.12 PIK50644.1 - 4.7e-05 23.3 0.9 0.24 11.5 0.5 2.3 1 1 1 2 2 2 2 Gas vesicle protein G DUF4487 PF14868.6 PIK50645.1 - 3e-90 303.6 19.4 3e-90 303.6 19.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4487) RTC PF01137.21 PIK50645.1 - 0.00079 18.7 0.0 0.0013 18.0 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase zf-C2H2_2 PF12756.7 PIK50646.1 - 3.4e-07 30.5 21.7 9.3e-05 22.7 1.9 4.1 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 PIK50646.1 - 0.00081 19.1 7.5 0.0083 15.9 1.4 4.2 4 0 0 4 4 4 2 U1 zinc finger zf-C2H2_jaz PF12171.8 PIK50646.1 - 0.0014 18.8 4.3 0.0014 18.8 4.3 4.4 4 1 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK50646.1 - 0.0035 17.7 2.8 0.0035 17.7 2.8 4.7 4 1 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK50646.1 - 0.0086 16.1 1.1 0.0086 16.1 1.1 3.6 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 PIK50646.1 - 0.037 14.2 1.1 0.037 14.2 1.1 3.7 3 2 2 5 5 5 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 PIK50646.1 - 0.047 14.5 1.8 0.047 14.5 1.8 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK50646.1 - 4.5 7.9 8.9 6.5 7.4 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger double domain RINGv PF12906.7 PIK50649.1 - 9.5e-14 51.3 9.7 9.5e-14 51.3 9.7 2.2 2 0 0 2 2 2 1 RING-variant domain DUF1084 PF06454.11 PIK50649.1 - 5.7e-08 32.5 10.2 5.7e-08 32.5 10.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1084) EGF_Tenascin PF18720.1 PIK50649.1 - 0.028 14.5 10.4 0.1 12.7 10.4 2.1 1 0 0 1 1 1 0 Tenascin EGF domain zf-RING_2 PF13639.6 PIK50649.1 - 0.2 12.0 9.1 0.59 10.5 9.1 1.9 1 0 0 1 1 1 0 Ring finger domain Rab_eff_C PF04698.12 PIK50650.1 - 0.12 10.6 0.4 0.17 10.1 0.4 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus Lipase PF00151.19 PIK50651.1 - 4.8e-66 223.3 2.1 7.1e-66 222.8 2.1 1.3 1 0 0 1 1 1 1 Lipase DUF900 PF05990.12 PIK50651.1 - 0.00016 21.2 0.0 0.00023 20.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.14 PIK50651.1 - 0.082 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 PIK50651.1 - 0.12 13.0 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family 7tm_1 PF00001.21 PIK50652.1 - 6.9e-38 130.5 9.4 9.4e-38 130.0 9.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK50652.1 - 1.6e-05 24.7 11.4 1.6e-05 24.7 11.4 2.4 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1642 PF07852.11 PIK50652.1 - 0.062 13.9 3.4 0.12 12.9 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1642) CBM_4_9 PF02018.17 PIK50652.1 - 0.068 13.4 1.3 0.11 12.8 1.3 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain DUF2207 PF09972.9 PIK50652.1 - 0.072 11.8 0.1 0.072 11.8 0.1 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Serpentine_r_xa PF03383.15 PIK50652.1 - 0.11 12.4 4.8 0.16 11.9 3.2 2.2 1 1 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa Gln-synt_C PF00120.24 PIK50653.1 - 1.6e-16 60.3 0.1 2.6e-15 56.3 0.1 2.2 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 PIK50653.1 - 1.8e-11 43.6 0.1 3.8e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain ANAPC5 PF12862.7 PIK50654.1 - 2.6e-28 97.9 15.2 4.1e-27 94.1 3.9 4.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 5 TPR_2 PF07719.17 PIK50654.1 - 1.9e-06 27.5 5.1 0.41 10.9 0.6 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK50654.1 - 8.4e-06 26.0 6.4 0.0027 18.0 0.1 3.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK50654.1 - 4.7e-05 23.9 2.7 2.4 9.2 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK50654.1 - 5.9e-05 22.8 2.1 0.52 10.3 0.9 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK50654.1 - 0.00025 21.0 1.6 0.8 10.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK50654.1 - 0.00054 19.7 2.2 3.3 7.7 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK50654.1 - 0.0014 19.1 2.9 0.95 10.2 0.2 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK50654.1 - 0.23 11.6 5.0 0.87 9.8 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK50654.1 - 0.89 10.1 9.4 19 5.8 0.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK50654.1 - 1.1 8.9 4.1 6.6 6.4 0.2 3.2 3 1 0 3 3 3 0 26S proteasome subunit RPN7 Exo_endo_phos PF03372.23 PIK50655.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SPACA9 PF15120.6 PIK50656.1 - 6.4e-43 146.4 0.2 9.6e-43 145.8 0.2 1.2 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 MIOX PF05153.15 PIK50656.1 - 0.1 12.2 0.2 0.1 12.2 0.2 1.5 2 0 0 2 2 2 0 Myo-inositol oxygenase WD40 PF00400.32 PIK50657.1 - 3.2e-47 157.5 16.1 3.2e-07 30.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50657.1 - 1.4e-12 47.7 0.0 0.0051 17.1 0.0 5.4 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK50657.1 - 1.1e-06 27.9 0.2 0.68 8.8 0.0 5.1 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK50657.1 - 4.3e-05 23.0 0.0 0.0064 15.9 0.0 3.4 3 1 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 PIK50657.1 - 0.00011 21.0 2.0 1.5 7.3 0.0 4.2 2 1 2 4 4 4 2 Nucleoporin Nup120/160 ZU5 PF00791.20 PIK50658.1 - 7.4e-09 35.9 0.1 1.5e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain ZU5 PF00791.20 PIK50659.1 - 9.1e-12 45.2 0.0 2.8e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Pkinase PF00069.25 PIK50660.1 - 2.5e-32 112.3 0.1 3.1e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50660.1 - 1.2e-12 47.7 0.0 1.5e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK50660.1 - 0.0012 18.8 0.0 0.0025 17.8 0.0 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK50660.1 - 0.0032 16.8 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK50660.1 - 0.01 15.4 0.0 0.031 13.9 0.0 1.7 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 PIK50660.1 - 0.019 13.8 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 PIK50660.1 - 0.099 11.9 0.0 0.39 10.0 0.0 2.0 2 1 0 2 2 2 0 Kinase-like CUB PF00431.20 PIK50661.1 - 7.2e-25 87.5 0.0 7.9e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 CUB domain Pkinase PF00069.25 PIK50662.1 - 1.9e-30 106.1 0.5 2.7e-30 105.6 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50662.1 - 1.2e-14 54.2 0.7 2.7e-14 53.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK50662.1 - 0.00031 20.7 0.0 0.0022 18.0 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK50662.1 - 0.00053 19.4 0.0 0.00077 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK50662.1 - 0.0031 17.1 0.0 0.016 14.8 0.0 1.9 1 1 1 2 2 2 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 PIK50662.1 - 0.042 12.6 0.0 0.062 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK50662.1 - 0.099 11.6 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase BCLP PF12304.8 PIK50662.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Beta-casein like protein DED PF01335.21 PIK50663.1 - 0.00054 20.2 0.3 0.00054 20.2 0.3 1.8 2 1 0 2 2 2 1 Death effector domain HIP1_clath_bdg PF16515.5 PIK50664.1 - 0.0076 16.8 45.2 0.028 15.0 20.2 2.6 2 1 0 2 2 2 2 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 PIK50664.1 - 0.19 12.2 54.7 0.065 13.8 26.1 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region FAM25 PF15825.5 PIK50664.1 - 0.28 11.6 5.0 2.2 8.7 0.2 3.3 3 0 0 3 3 3 0 FAM25 family GAS PF13851.6 PIK50664.1 - 0.34 10.2 50.2 0.14 11.4 21.6 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding UPF0160 PF03690.13 PIK50664.1 - 1.6 8.3 13.9 3.3 7.3 13.5 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0160) LMBR1 PF04791.16 PIK50664.1 - 2.6 6.8 16.1 3.8 6.3 16.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4175 PF13779.6 PIK50664.1 - 3.2 5.5 32.6 4.2 5.2 32.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ERM PF00769.19 PIK50664.1 - 3.5 7.4 54.4 0.082 12.7 31.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3584 PF12128.8 PIK50664.1 - 4.2 4.8 42.4 5.6 4.3 42.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF99 PF01949.16 PIK50664.1 - 9.3 5.6 6.5 1.9 7.9 1.3 2.3 1 1 2 3 3 3 0 Protein of unknown function DUF99 Integrin_alpha2 PF08441.12 PIK50665.1 - 4.2e-34 118.3 1.7 3.9e-33 115.0 0.0 2.0 1 1 1 2 2 2 2 Integrin alpha Integrin_alpha PF00357.20 PIK50665.1 - 0.0033 17.3 0.2 0.0073 16.2 0.2 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP PF01839.23 PIK50666.1 - 1.3e-06 28.4 11.8 0.00029 20.9 2.8 3.4 3 0 0 3 3 3 2 FG-GAP repeat Integrin_alpha2 PF08441.12 PIK50666.1 - 4.8e-06 25.7 0.0 7.6e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Integrin alpha VCBS PF13517.6 PIK50666.1 - 0.00029 21.4 2.4 0.0024 18.4 2.3 2.4 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK50666.1 - 0.00069 19.8 4.3 0.027 14.7 1.9 2.9 2 0 0 2 2 2 1 FG-GAP repeat Man-6-P_recep PF02157.15 PIK50667.1 - 1e-34 119.8 0.1 1.2e-34 119.5 0.1 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 PIK50667.1 - 0.0033 17.3 0.0 0.0042 17.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 EF-hand_7 PF13499.6 PIK50668.1 - 2.6e-23 82.2 3.8 1.1e-12 48.2 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK50668.1 - 2.3e-20 72.2 4.8 5.5e-10 38.9 0.2 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK50668.1 - 2.4e-17 61.1 12.1 1e-05 24.7 2.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK50668.1 - 2.9e-16 57.9 5.4 0.0014 18.4 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK50668.1 - 2.8e-08 32.9 6.7 0.021 14.3 0.4 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 PIK50668.1 - 3.1e-05 24.2 0.2 0.0015 18.8 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 PIK50668.1 - 3.6e-05 23.6 1.2 0.017 15.0 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 PIK50668.1 - 0.0016 18.4 3.6 0.041 13.8 0.3 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.9 PIK50668.1 - 0.0056 17.0 0.4 0.18 12.1 0.1 2.6 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 PIK50668.1 - 0.0059 16.4 1.4 0.058 13.2 0.3 2.1 2 0 0 2 2 2 1 SurA N-terminal domain SurA_N_2 PF13623.6 PIK50668.1 - 0.0099 15.8 0.9 0.7 9.7 0.1 2.2 2 0 0 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 PIK50668.1 - 0.01 16.2 1.2 0.36 11.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain LETM1 PF07766.13 PIK50668.1 - 0.09 12.1 0.2 0.13 11.6 0.2 1.5 1 1 0 1 1 1 0 LETM1-like protein AA_permease_2 PF13520.6 PIK50669.1 - 2.8e-32 112.1 37.8 2.8e-32 112.1 37.8 2.6 2 1 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 PIK50669.1 - 3.2e-27 95.3 34.0 3.2e-27 95.3 34.0 2.3 2 1 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 PIK50669.1 - 4.3e-21 74.7 12.6 4.3e-21 74.7 12.6 3.1 2 0 0 2 2 2 1 C-terminus of AA_permease Ras PF00071.22 PIK50671.1 - 3e-37 127.7 0.0 3.6e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK50671.1 - 5.4e-10 39.5 0.0 1.1e-09 38.5 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK50671.1 - 0.0087 15.6 0.0 0.015 14.9 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK50671.1 - 0.015 14.7 0.0 0.021 14.3 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family PET117 PF15786.5 PIK50671.1 - 0.024 14.9 0.1 0.036 14.3 0.1 1.3 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Methyltr_RsmB-F PF01189.17 PIK50672.1 - 5.8e-65 218.7 0.0 9.2e-65 218.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 PIK50672.1 - 2e-08 34.6 0.0 4.8e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 PIK50672.1 - 0.00077 19.3 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein FtsJ PF01728.19 PIK50672.1 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase TRM PF02005.16 PIK50672.1 - 0.0076 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Ubie_methyltran PF01209.18 PIK50672.1 - 0.042 13.2 0.0 0.086 12.2 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 PIK50672.1 - 0.043 13.6 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 PIK50672.1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LRR_8 PF13855.6 PIK50673.1 - 6.1e-18 64.3 28.1 9.9e-08 31.6 4.5 4.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK50673.1 - 3.5e-16 59.0 31.2 1.7e-06 28.2 5.6 4.7 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) B3_4 PF03483.17 PIK50673.1 - 8e-05 22.4 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain LRR_9 PF14580.6 PIK50673.1 - 0.00017 21.1 12.8 0.048 13.2 2.3 2.9 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK50673.1 - 0.00083 19.6 18.8 9 7.3 0.1 6.4 5 1 0 5 5 5 2 Leucine Rich Repeat CPSase_L_D3 PF02787.19 PIK50673.1 - 0.026 14.9 0.9 0.11 12.8 0.2 2.3 2 1 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain FlbD PF06289.11 PIK50673.1 - 0.049 13.2 2.1 0.13 11.9 1.1 2.1 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins Hormone_recep PF00104.30 PIK50674.1 - 2.9e-14 53.1 0.7 3.6e-14 52.8 0.7 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor AKAP95 PF04988.12 PIK50674.1 - 0.13 12.5 0.2 0.21 11.8 0.2 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) zf-FLZ PF04570.14 PIK50675.1 - 0.078 12.5 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 RVT_1 PF00078.27 PIK50677.1 - 0.0025 17.4 0.1 0.0041 16.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK50678.1 - 5.5e-12 45.9 0.0 8.7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK50678.1 - 4.4e-05 23.1 0.0 7.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK50678.1 - 0.014 15.7 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3368 PF11848.8 PIK50678.1 - 0.015 15.1 1.5 0.039 13.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) DAP3 PF10236.9 PIK50678.1 - 0.024 13.8 0.0 0.046 12.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 CUE PF02845.16 PIK50678.1 - 0.24 11.2 0.4 19 5.1 0.0 2.6 2 0 0 2 2 2 0 CUE domain DUF1664 PF07889.12 PIK50679.1 - 2.8 8.0 7.0 0.33 11.0 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NACHT PF05729.12 PIK50681.1 - 7e-10 39.1 0.0 9.8e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK50681.1 - 4.3e-05 23.2 0.0 9.2e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK50681.1 - 0.0085 16.4 0.0 0.022 15.0 0.0 1.7 1 1 1 2 2 2 1 AAA domain DAP3 PF10236.9 PIK50681.1 - 0.03 13.5 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF3368 PF11848.8 PIK50681.1 - 0.036 13.9 0.4 0.036 13.9 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) CUE PF02845.16 PIK50681.1 - 0.23 11.2 0.4 18 5.1 0.0 2.5 2 0 0 2 2 2 0 CUE domain DUF4366 PF14283.6 PIK50682.1 - 9.3 6.3 10.8 85 3.2 10.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Elongin_A PF06881.11 PIK50683.1 - 0.011 16.3 0.9 0.36 11.4 0.2 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A SRP-alpha_N PF04086.13 PIK50684.1 - 5.4e-52 177.5 14.8 7.3e-52 177.1 14.8 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 PIK50684.1 - 2.2e-15 56.8 0.1 6e-15 55.4 0.0 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 PIK50684.1 - 7.6e-09 35.7 0.1 1e-07 32.0 0.0 2.6 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_16 PF13191.6 PIK50684.1 - 0.00051 20.5 0.0 0.0021 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 PIK50684.1 - 0.0012 17.9 0.0 0.0022 17.0 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 PIK50684.1 - 0.0035 17.4 0.1 0.019 15.0 0.0 2.1 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 PIK50684.1 - 0.04 13.3 0.1 0.097 12.1 0.0 1.7 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Longin PF13774.6 PIK50684.1 - 0.12 12.4 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 Regulated-SNARE-like domain SRP54 PF00448.22 PIK50685.1 - 4.7e-17 62.3 0.2 1e-16 61.2 0.2 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain PPI_Ypi1 PF07491.11 PIK50686.1 - 1.4e-23 82.5 7.2 2.9e-23 81.5 7.2 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor TB PF00683.17 PIK50686.1 - 1.6 8.6 8.5 6.9 6.5 8.5 2.0 1 1 0 1 1 1 0 TB domain PDZ PF00595.24 PIK50687.1 - 5.2e-24 84.4 2.0 4.4e-12 46.2 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK50687.1 - 5.5e-12 45.3 0.0 1.8e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK50687.1 - 0.00027 21.2 0.1 0.61 10.4 0.0 2.9 3 0 0 3 3 3 2 PDZ domain HYR PF02494.16 PIK50688.1 - 7.7e-59 196.0 14.3 3.7e-19 68.8 0.3 4.1 4 0 0 4 4 4 4 HYR domain EGF PF00008.27 PIK50688.1 - 0.018 15.4 7.9 0.018 15.4 7.9 2.0 2 0 0 2 2 2 0 EGF-like domain FBA_1 PF07734.13 PIK50688.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 F-box associated Laminin_EGF PF00053.24 PIK50688.1 - 0.46 10.7 11.8 1.2 9.3 11.8 1.7 1 0 0 1 1 1 0 Laminin EGF domain 7tm_1 PF00001.21 PIK50689.1 - 1.5e-08 34.3 0.1 1.6e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4482 PF14818.6 PIK50689.1 - 0.12 13.2 1.8 0.23 12.3 1.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) CXCXC PF03128.14 PIK50690.1 - 2.8e-14 52.4 175.3 0.0058 17.0 2.3 18.7 18 0 0 18 18 18 16 CXCXC repeat EF-hand_1 PF00036.32 PIK50691.1 - 6.8e-20 69.1 6.0 0.006 16.0 0.0 6.7 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.6 PIK50691.1 - 2.5e-19 69.5 12.5 1.5e-08 35.0 0.1 4.9 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 PIK50691.1 - 3.5e-15 54.7 2.1 0.0015 17.9 0.0 5.9 5 1 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 PIK50691.1 - 3.4e-12 45.2 4.4 0.052 13.5 0.0 6.3 6 0 0 6 6 6 3 EF-hand domain EF-hand_8 PF13833.6 PIK50691.1 - 2.6e-10 40.0 2.6 0.026 14.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK50691.1 - 8.5e-07 29.3 11.7 0.0033 17.7 1.4 3.2 2 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region DUF4073 PF13285.6 PIK50691.1 - 0.054 13.2 0.7 0.095 12.3 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) FAM124 PF15067.6 PIK50692.1 - 0.00014 21.6 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 FAM124 family LRR_4 PF12799.7 PIK50693.1 - 9.1e-15 54.5 19.4 7.9e-06 26.1 1.0 7.1 4 3 4 8 8 8 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 PIK50693.1 - 2.8e-08 33.5 0.0 5.5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 PIK50693.1 - 2.2e-07 30.5 10.9 0.077 12.8 0.9 6.6 2 1 4 6 6 6 3 Leucine rich repeat F-box PF00646.33 PIK50693.1 - 2.3e-06 27.3 0.1 1.5e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 PIK50693.1 - 3.1e-05 23.7 13.9 7.4 6.9 0.1 7.2 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.33 PIK50693.1 - 7.7e-05 22.7 21.2 1.7 9.5 0.1 9.2 10 1 0 10 10 10 2 Leucine Rich Repeat YL1 PF05764.13 PIK50693.1 - 0.0009 19.4 6.1 0.0014 18.8 6.1 1.2 1 0 0 1 1 1 1 YL1 nuclear protein LCD1 PF09798.9 PIK50693.1 - 0.13 10.8 2.6 0.17 10.3 2.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein AP3D1 PF06375.11 PIK50693.1 - 0.26 11.5 13.4 0.49 10.6 13.4 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DHHC PF01529.20 PIK50694.1 - 2e-24 86.2 14.5 2e-24 86.2 14.5 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase bZIP_1 PF00170.21 PIK50696.1 - 1.9e-13 50.3 11.5 1.9e-13 50.3 11.5 2.8 2 1 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 PIK50696.1 - 0.00016 21.7 13.2 0.00016 21.7 13.2 3.6 2 1 0 2 2 2 1 Basic region leucine zipper LURAP PF14854.6 PIK50696.1 - 0.072 13.0 0.2 0.072 13.0 0.2 1.9 2 0 0 2 2 2 0 Leucine rich adaptor protein Ribosomal_L6e PF01159.19 PIK50696.1 - 1.4 9.5 8.9 0.92 10.1 2.9 2.5 2 0 0 2 2 2 0 Ribosomal protein L6e YabA PF06156.13 PIK50696.1 - 2 9.1 10.6 1.2 9.8 1.2 2.6 2 0 0 2 2 2 0 Initiation control protein YabA EMC3_TMCO1 PF01956.16 PIK50696.1 - 6.5 6.4 7.7 4.7 6.9 0.1 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like MCU PF04678.13 PIK50696.1 - 6.6 6.8 8.8 11 6.1 4.2 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter FlaC_arch PF05377.11 PIK50696.1 - 6.6 7.2 9.9 0.17 12.3 1.8 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 PIK50696.1 - 9.3 6.8 18.5 0.43 11.0 1.0 2.8 2 1 0 2 2 2 0 Cell division protein ZapB G-patch PF01585.23 PIK50698.1 - 1.7e-12 47.0 0.5 4e-12 45.8 0.5 1.6 1 0 0 1 1 1 1 G-patch domain SMN PF06003.12 PIK50698.1 - 4.1e-05 23.0 0.0 4.1e-05 23.0 0.0 2.4 3 0 0 3 3 3 1 Survival motor neuron protein (SMN) DUF1325 PF07039.11 PIK50698.1 - 0.0016 18.6 0.1 0.0062 16.6 0.0 2.1 2 0 0 2 2 2 1 SGF29 tudor-like domain TUDOR PF00567.24 PIK50698.1 - 0.0051 16.8 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 Tudor domain zf-CCCH_4 PF18044.1 PIK50698.1 - 0.0081 15.9 4.4 0.023 14.5 4.4 1.8 1 1 0 1 1 1 1 CCCH-type zinc finger DUF4537 PF15057.6 PIK50698.1 - 0.011 15.7 0.0 0.059 13.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) zf_CCCH_4 PF18345.1 PIK50698.1 - 0.024 14.7 1.3 0.15 12.2 1.3 2.3 1 1 0 1 1 1 0 Zinc finger domain G-patch_2 PF12656.7 PIK50698.1 - 0.45 10.6 3.5 0.46 10.6 0.0 2.5 2 0 0 2 2 2 0 G-patch domain zf-CCCH PF00642.24 PIK50698.1 - 0.58 10.1 4.5 1.7 8.6 4.5 1.8 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF4570 PF15134.6 PIK50698.1 - 5.2 7.1 15.0 1 9.4 8.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) DUF1140 PF06600.11 PIK50698.1 - 9.2 6.8 8.0 8.7 6.9 1.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1140) Longin PF13774.6 PIK50699.1 - 2e-25 88.6 0.9 4e-25 87.7 0.9 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 PIK50699.1 - 1.7e-16 59.8 0.7 2.7e-16 59.1 0.7 1.4 1 0 0 1 1 1 1 Synaptobrevin Sec20 PF03908.13 PIK50699.1 - 0.004 17.1 0.4 0.0092 15.9 0.1 1.8 2 0 0 2 2 2 1 Sec20 Ligase_CoA PF00549.19 PIK50699.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 CoA-ligase NCKAP5 PF15246.6 PIK50699.1 - 0.18 11.4 0.6 0.24 11.0 0.6 1.2 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Sec16_C PF12931.7 PIK50702.1 - 8.5e-42 143.8 0.4 1.5e-41 143.0 0.4 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 PIK50702.1 - 1.8e-08 35.0 0.0 6.7e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region DUF5588 PF17826.1 PIK50702.1 - 0.035 13.0 0.1 0.062 12.2 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5588) DBP10CT PF08147.12 PIK50703.1 - 0.27 11.5 0.1 0.27 11.5 0.1 2.8 3 0 0 3 3 3 0 DBP10CT (NUC160) domain zf-C3HC4_3 PF13920.6 PIK50706.1 - 3.6e-13 49.2 13.7 6.9e-13 48.2 13.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK50706.1 - 0.00046 20.0 13.8 0.00092 19.0 13.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK50706.1 - 0.99 9.4 15.0 2.3 8.3 15.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 PIK50706.1 - 1.3 9.4 18.8 0.23 11.8 14.9 1.8 2 0 0 2 2 2 0 Ring finger domain DDE_Tnp_1_7 PF13843.6 PIK50707.1 - 5.3e-42 144.4 0.0 6.8e-42 144.0 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 NOA36 PF06524.12 PIK50707.1 - 4.2 6.6 10.6 5.7 6.2 10.6 1.1 1 0 0 1 1 1 0 NOA36 protein BEN PF10523.9 PIK50708.1 - 6.2e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 BEN domain zf-CCHC PF00098.23 PIK50709.1 - 4.5e-06 26.5 16.2 0.0011 18.9 0.2 3.7 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK50709.1 - 0.0015 18.4 7.8 0.17 11.7 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK50709.1 - 0.014 15.3 12.6 0.39 10.7 1.2 3.7 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK50709.1 - 0.036 13.9 0.2 0.036 13.9 0.2 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK50709.1 - 0.037 13.7 0.8 0.037 13.7 0.8 2.7 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK50709.1 - 0.13 12.0 11.3 8.4 6.2 0.4 3.5 2 1 1 3 3 3 0 Zinc knuckle zf-tcix PF14952.6 PIK50710.1 - 0.12 12.0 0.1 0.36 10.5 0.1 1.8 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding zf-CCHC_6 PF15288.6 PIK50710.1 - 0.77 9.6 4.5 0.93 9.4 2.8 2.0 2 0 0 2 2 2 0 Zinc knuckle Zeta_toxin PF06414.12 PIK50712.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin zf-RING_UBOX PF13445.6 PIK50713.1 - 2.3e-09 37.1 7.4 2.3e-09 37.1 7.4 3.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK50713.1 - 2.9e-08 33.4 8.1 2.9e-08 33.4 8.1 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK50713.1 - 8.2e-08 32.3 8.2 8.2e-08 32.3 8.2 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK50713.1 - 8.5e-08 31.9 6.3 8.5e-08 31.9 6.3 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK50713.1 - 3.8e-07 30.3 9.1 3.8e-07 30.3 9.1 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK50713.1 - 4.1e-07 29.7 9.0 4.1e-07 29.7 9.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK50713.1 - 1.4e-05 25.0 8.4 1.4e-05 25.0 8.4 2.6 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK50713.1 - 0.00014 21.6 8.2 0.00014 21.6 8.2 2.9 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-B_box PF00643.24 PIK50713.1 - 0.00056 20.0 6.1 0.00056 20.0 6.1 3.0 3 1 0 3 3 3 1 B-box zinc finger DUF2336 PF10098.9 PIK50713.1 - 0.042 13.3 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) DUF2040 PF09745.9 PIK50713.1 - 0.06 13.4 0.3 0.06 13.4 0.3 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) zf-RING_6 PF14835.6 PIK50713.1 - 0.16 11.9 11.1 1.4 8.8 3.8 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-Sec23_Sec24 PF04810.15 PIK50713.1 - 0.84 9.7 9.6 1.4 9.0 0.6 3.4 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger CTU2 PF10288.9 PIK50713.1 - 1.4 9.2 6.6 2.5 8.4 6.3 1.7 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 CEBP_ZZ PF16366.5 PIK50713.1 - 1.4 9.2 11.5 0.14 12.4 0.6 2.8 2 1 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Pkinase PF00069.25 PIK50714.1 - 5.2e-21 75.2 0.0 6.2e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50714.1 - 1.1e-06 28.2 0.0 1.4e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK50715.1 - 1.6e-37 129.3 0.1 2.3e-37 128.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50715.1 - 2.2e-23 82.9 0.1 3.2e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK50715.1 - 0.00028 20.3 0.1 0.00097 18.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK50715.1 - 0.0052 16.7 0.2 0.0091 15.9 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK50715.1 - 0.095 11.6 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 PIK50715.1 - 0.16 11.6 0.6 0.45 10.1 0.1 1.8 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 PIK50715.1 - 0.16 10.7 0.1 0.29 9.9 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF1648 PF07853.11 PIK50716.1 - 0.18 11.4 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) MtrG PF04210.13 PIK50717.1 - 0.012 15.5 0.5 0.037 13.9 0.0 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Sipho_Gp157 PF05565.11 PIK50717.1 - 0.014 15.5 1.6 0.016 15.2 1.6 1.1 1 0 0 1 1 1 0 Siphovirus Gp157 rRNA_methylase PF06962.12 PIK50717.1 - 0.04 13.9 0.0 0.079 12.9 0.0 1.6 2 0 0 2 2 2 0 Putative rRNA methylase DUF762 PF05555.11 PIK50721.1 - 0.0034 17.0 0.0 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 Coxiella burnetii protein of unknown function (DUF762) RVT_1 PF00078.27 PIK50722.1 - 2e-16 60.2 0.0 3.4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Beta_helix PF13229.6 PIK50723.1 - 1.6e-07 31.3 1.0 3e-07 30.4 1.0 1.4 1 0 0 1 1 1 1 Right handed beta helix region Pectate_lyase_3 PF12708.7 PIK50723.1 - 0.017 14.9 0.3 0.061 13.2 0.3 2.0 1 1 0 1 1 1 0 Pectate lyase superfamily protein NosD PF05048.13 PIK50723.1 - 0.019 14.2 1.2 0.03 13.6 1.2 1.3 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) APS_kinase PF01583.20 PIK50723.1 - 0.07 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Peptidase_M4_C PF02868.15 PIK50723.1 - 0.097 12.5 0.0 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 Thermolysin metallopeptidase, alpha-helical domain DUF1759 PF03564.15 PIK50724.1 - 0.00013 22.0 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DivIVA PF05103.13 PIK50724.1 - 0.059 13.4 5.7 0.1 12.7 5.7 1.3 1 0 0 1 1 1 0 DivIVA protein COQ9 PF08511.11 PIK50725.1 - 1.2e-28 98.7 0.3 2.6e-28 97.6 0.1 1.7 2 0 0 2 2 2 1 COQ9 RVT_1 PF00078.27 PIK50725.1 - 1.9e-15 57.0 0.1 4.3e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-TFIIIC PF12660.7 PIK50725.1 - 0.12 12.3 0.6 0.3 11.1 0.2 1.8 2 0 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex SH2 PF00017.24 PIK50726.1 - 8.5e-10 38.6 0.0 3e-09 36.9 0.0 2.0 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 PIK50726.1 - 3e-08 33.9 0.1 6.4e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 SOCS box TRAP_alpha PF03896.16 PIK50727.1 - 2.3e-91 305.9 4.5 3.5e-91 305.3 4.5 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit PTPRCAP PF15713.5 PIK50727.1 - 0.0029 17.9 14.5 0.005 17.1 14.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 PIK50727.1 - 0.42 8.8 19.0 0.54 8.4 19.0 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 PIK50727.1 - 3.1 6.0 14.3 4.3 5.5 14.3 1.1 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 PIK50727.1 - 3.2 7.4 23.0 6.1 6.5 23.0 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.13 PIK50727.1 - 5.2 5.1 27.1 6.7 4.7 27.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 PIK50727.1 - 5.7 6.3 22.7 8.6 5.7 22.7 1.2 1 0 0 1 1 1 0 SDA1 zf-C3HC4_3 PF13920.6 PIK50728.1 - 4.3e-06 26.5 21.1 8.9e-06 25.5 15.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 PIK50728.1 - 0.029 14.2 12.9 0.029 14.2 12.9 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 PIK50728.1 - 0.036 13.9 9.8 0.036 13.9 9.8 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 PIK50728.1 - 0.15 12.4 8.1 0.75 10.1 0.2 3.2 2 0 0 2 2 2 0 zinc-ribbon zf-RING_14 PF17978.1 PIK50728.1 - 0.21 12.0 10.9 0.11 13.0 8.4 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain UPF0547 PF10571.9 PIK50728.1 - 0.25 11.4 7.1 1.5 9.0 0.5 3.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Zn-ribbon_8 PF09723.10 PIK50728.1 - 0.62 10.2 11.3 3.1 8.0 1.5 2.8 1 1 1 2 2 2 0 Zinc ribbon domain zf_UBZ PF18439.1 PIK50728.1 - 0.81 9.3 7.0 0.23 11.1 0.6 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-LITAF-like PF10601.9 PIK50728.1 - 6.2 7.2 21.7 7.2 7.0 0.4 3.2 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain IBR PF01485.21 PIK50731.1 - 5.1e-09 36.2 35.7 3.7e-05 23.9 11.5 4.1 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 PIK50731.1 - 2.2e-06 27.4 7.3 2.2e-06 27.4 7.3 4.3 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK50731.1 - 0.00011 22.5 7.6 0.00011 22.5 7.6 4.3 3 2 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK50731.1 - 0.00024 21.1 7.9 0.00024 21.1 7.9 3.7 4 1 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK50731.1 - 0.00083 19.3 6.7 0.00083 19.3 6.7 4.5 4 1 1 5 5 5 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK50731.1 - 0.0011 18.7 6.5 0.0011 18.7 6.5 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK50731.1 - 0.0053 16.5 5.3 0.0053 16.5 5.3 3.1 3 0 0 3 3 3 1 RING-like zinc finger zf-ribbon_3 PF13248.6 PIK50731.1 - 0.24 10.9 0.2 0.24 10.9 0.2 5.2 5 1 1 6 6 6 0 zinc-ribbon domain PRP21_like_P PF12230.8 PIK50731.1 - 1.3 8.8 6.6 2.2 8.1 0.3 2.7 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein Trm112p PF03966.16 PIK50731.1 - 3.9 8.1 7.5 0.57 10.8 2.0 2.5 3 0 0 3 3 3 0 Trm112p-like protein IBR PF01485.21 PIK50732.1 - 1.6e-06 28.2 46.0 0.00027 21.1 7.8 4.3 3 2 0 3 3 3 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 PIK50732.1 - 1.4e-05 24.8 11.5 1.4e-05 24.8 11.5 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK50732.1 - 1.8e-05 24.9 10.7 1.8e-05 24.9 10.7 4.2 4 1 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 PIK50732.1 - 2.2e-05 24.3 9.9 2.2e-05 24.3 9.9 4.1 4 1 1 5 5 5 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK50732.1 - 0.00013 21.9 11.5 0.00013 21.9 11.5 3.2 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK50732.1 - 0.0013 18.5 8.6 0.0013 18.5 8.6 4.0 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK50732.1 - 0.0043 16.8 4.4 0.0043 16.8 4.4 2.8 3 0 0 3 3 3 1 RING-like zinc finger Maf1 PF09174.10 PIK50733.1 - 9.5e-29 100.8 0.2 1.2e-28 100.4 0.2 1.1 1 0 0 1 1 1 1 Maf1 regulator Maf1 PF09174.10 PIK50734.1 - 1.8e-05 25.0 0.0 2.2e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator Peptidase_S28 PF05577.12 PIK50735.1 - 1.4e-119 399.8 0.1 1.5e-119 399.6 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 mono-CXXC PF15626.6 PIK50735.1 - 0.22 11.9 0.5 1.1 9.7 0.2 2.0 2 0 0 2 2 2 0 single CXXC unit Tubulin PF00091.25 PIK50736.1 - 3.3e-69 233.0 0.0 5.3e-69 232.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK50736.1 - 2.5e-43 147.2 0.1 4e-43 146.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 PIK50736.1 - 1e-05 25.8 0.0 2.8e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 PIK50736.1 - 0.0066 16.1 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 PIK50736.1 - 0.015 14.5 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Tubulin PF00091.25 PIK50737.1 - 7.1e-32 111.2 0.0 7.8e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 PIK50737.1 - 5.5e-06 26.7 0.0 9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 PIK50738.1 - 1.3e-68 231.1 0.0 2.1e-68 230.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK50738.1 - 4.2e-43 146.5 0.1 6.7e-43 145.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 PIK50738.1 - 2.1e-05 24.8 0.1 5.9e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 PIK50738.1 - 0.0063 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 PIK50738.1 - 0.0092 15.2 0.0 0.02 14.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Tubulin PF00091.25 PIK50739.1 - 6.6e-69 232.1 0.0 1.1e-68 231.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK50739.1 - 5.6e-44 149.3 0.1 8.7e-44 148.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 PIK50739.1 - 2.4e-05 24.6 0.1 7.6e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 PIK50739.1 - 0.032 13.4 0.0 0.075 12.2 0.0 1.6 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 PIK50739.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin PF00091.25 PIK50740.1 - 1.1e-46 159.5 0.0 2e-46 158.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK50740.1 - 2.7e-43 147.1 0.1 4.4e-43 146.4 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK50740.1 - 0.0049 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 PIK50740.1 - 0.017 14.4 0.0 0.038 13.2 0.0 1.6 2 0 0 2 2 2 0 Tubulin like Tubulin_C PF03953.17 PIK50741.1 - 8.2e-30 103.6 1.1 5.3e-29 100.9 1.1 2.1 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 PIK50741.1 - 4e-16 59.8 0.1 7.2e-15 55.7 0.0 2.2 1 1 1 2 2 2 1 Tubulin/FtsZ family, GTPase domain zf-RING_9 PF13901.6 PIK50742.1 - 1.1e-63 214.9 22.1 1e-62 211.8 12.1 2.4 2 0 0 2 2 2 2 Putative zinc-RING and/or ribbon C1_1 PF00130.22 PIK50742.1 - 2.9e-07 30.2 35.2 7.6e-07 28.9 6.9 4.4 3 2 1 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 PIK50742.1 - 0.00018 21.4 20.1 0.0009 19.1 2.3 3.0 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 C1_2 PF03107.16 PIK50742.1 - 0.00021 21.6 3.1 0.00021 21.6 3.1 5.1 4 1 0 4 4 4 2 C1 domain PHD_3 PF13922.6 PIK50742.1 - 0.01 16.2 2.5 0.01 16.2 2.5 3.8 4 0 0 4 4 4 0 PHD domain of transcriptional enhancer, Asx DUF3420 PF11900.8 PIK50742.1 - 0.11 12.7 0.9 0.31 11.2 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) SAGA-Tad1 PF12767.7 PIK50744.1 - 5.1e-18 65.7 0.2 2e-13 50.6 0.3 2.3 1 1 0 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit EF-hand_1 PF00036.32 PIK50745.1 - 6.4e-10 37.9 1.7 0.0011 18.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK50745.1 - 1.5e-07 31.8 1.3 5.2e-07 30.0 1.3 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK50745.1 - 8.4e-07 28.4 1.3 0.01 15.7 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK50745.1 - 9.8e-06 24.8 1.2 0.00082 18.8 0.1 2.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 PIK50745.1 - 0.0027 17.5 0.5 0.033 14.0 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK50745.1 - 0.39 11.0 10.8 4.6 7.6 8.2 3.4 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Ank_2 PF12796.7 PIK50746.1 - 1.3e-18 67.4 0.1 2.8e-13 50.2 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK50746.1 - 5.4e-12 46.0 0.0 9.1e-09 35.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK50746.1 - 1.7e-11 44.0 0.0 0.00012 22.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 PIK50746.1 - 2.1e-10 39.9 0.2 3.5e-05 23.9 0.0 2.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK50746.1 - 7.7e-09 35.6 0.0 3.4e-05 24.0 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF4741 PF15897.5 PIK50747.1 - 0.077 12.8 0.3 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4741) BCNT PF07572.12 PIK50748.1 - 8e-28 96.3 0.1 1.3e-27 95.6 0.1 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development DUF4030 PF13222.6 PIK50749.1 - 0.017 15.3 1.9 0.027 14.6 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4030) RVT_1 PF00078.27 PIK50750.1 - 1.5e-36 126.0 0.1 2.2e-36 125.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 PIK50751.1 - 5.1e-34 117.8 0.0 6.9e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50751.1 - 1.3e-27 96.7 0.1 1.8e-27 96.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK50751.1 - 7.1e-05 21.7 0.0 0.00014 20.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 PIK50751.1 - 0.00099 18.7 0.1 0.0019 17.8 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK50751.1 - 0.19 11.6 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RNA_pol_Rpc34 PF05158.12 PIK50752.1 - 0.041 13.3 0.0 0.043 13.2 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit Pkinase PF00069.25 PIK50753.1 - 1.8e-22 80.0 0.2 2.3e-22 79.6 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50753.1 - 1.2e-16 60.9 0.0 1.6e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK50753.1 - 0.017 14.0 0.0 0.026 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 PIK50753.1 - 0.024 14.2 0.0 0.034 13.8 0.0 1.1 1 0 0 1 1 1 0 RIO1 family SRCR PF00530.18 PIK50754.1 - 4.2e-30 104.2 3.4 8.8e-30 103.2 3.4 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50754.1 - 9.2e-07 29.3 3.8 4.6e-05 23.9 1.3 2.6 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK50754.1 - 0.027 15.0 0.1 0.22 12.1 0.0 2.3 2 2 0 2 2 2 0 Hepsin, SRCR domain rve PF00665.26 PIK50755.1 - 5.7e-23 81.4 0.0 7.2e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50755.1 - 0.0033 17.2 0.0 0.0084 15.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK50756.1 - 4.8e-32 111.3 0.1 9.7e-32 110.3 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK50756.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.7 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC PF00098.23 PIK50757.1 - 3.9e-06 26.7 4.0 7.1e-06 25.9 4.0 1.5 1 0 0 1 1 1 1 Zinc knuckle T6SS_HCP PF05638.12 PIK50757.1 - 0.0009 19.6 0.2 0.0015 19.0 0.2 1.3 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp Myofilin PF15929.5 PIK50757.1 - 0.0018 18.7 0.4 0.0039 17.6 0.4 1.5 1 0 0 1 1 1 1 Myofilin zf-CCHC_2 PF13696.6 PIK50757.1 - 0.083 12.7 2.2 0.16 11.8 2.2 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK50757.1 - 0.22 11.3 5.1 0.52 10.1 5.1 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger SRCR PF00530.18 PIK50758.1 - 3.4e-105 345.2 23.8 5.5e-31 107.0 4.5 4.0 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50758.1 - 2.9e-21 75.8 6.6 4.9e-06 27.0 0.5 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK50758.1 - 4.8e-10 39.9 0.0 0.074 13.6 0.0 4.3 4 0 0 4 4 4 3 Hepsin, SRCR domain YecR PF13992.6 PIK50758.1 - 0.016 15.5 8.5 0.34 11.2 0.4 3.6 4 0 0 4 4 4 0 YecR-like lipoprotein SspH PF08141.12 PIK50758.1 - 0.02 15.0 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Small acid-soluble spore protein H family YtkA PF13115.6 PIK50758.1 - 0.027 15.1 0.1 12 6.6 0.0 2.3 2 0 0 2 2 2 0 YtkA-like SRCR PF00530.18 PIK50759.1 - 3.9e-57 190.9 7.9 2.5e-31 108.1 2.4 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50759.1 - 2.1e-10 41.0 2.9 3.9e-06 27.3 0.5 2.7 3 1 0 3 3 3 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK50759.1 - 2.3e-05 24.8 0.0 0.012 16.1 0.0 2.3 2 0 0 2 2 2 2 Hepsin, SRCR domain Adap_comp_sub PF00928.21 PIK50760.1 - 3.5e-23 82.3 0.0 5.3e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK50760.1 - 6.1e-06 26.2 0.1 1.2e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L36e PF01158.18 PIK50760.1 - 0.043 14.1 1.0 0.043 14.1 1.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L36e z-alpha PF02295.17 PIK50760.1 - 0.2 11.7 2.3 18 5.5 0.0 2.6 2 0 0 2 2 2 0 Adenosine deaminase z-alpha domain Exo_endo_phos_2 PF14529.6 PIK50761.1 - 4.8e-05 23.2 0.1 0.0001 22.1 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Ribonuc_2-5A PF06479.12 PIK50761.1 - 0.014 15.6 3.7 0.018 15.2 2.3 1.8 2 0 0 2 2 2 0 Ribonuclease 2-5A STN PF07660.14 PIK50761.1 - 0.019 14.7 0.0 0.095 12.5 0.0 2.1 2 0 0 2 2 2 0 Secretin and TonB N terminus short domain Minor_capsid_2 PF11114.8 PIK50761.1 - 0.12 12.5 0.2 0.27 11.3 0.2 1.6 1 1 0 1 1 1 0 Minor capsid protein Trypsin PF00089.26 PIK50762.1 - 7e-57 192.8 0.0 7.8e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK50762.1 - 9e-07 29.3 0.0 1.6e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK50762.1 - 0.0029 18.5 0.0 0.0062 17.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Lectin_C PF00059.21 PIK50763.1 - 6.4e-39 133.0 5.5 4.7e-19 69.1 0.1 2.8 2 0 0 2 2 2 2 Lectin C-type domain CUB PF00431.20 PIK50763.1 - 9.4e-09 35.6 0.8 3.1e-08 33.9 0.4 2.1 2 0 0 2 2 2 1 CUB domain UL45 PF05473.12 PIK50763.1 - 8.7e-05 22.2 0.2 0.0026 17.4 0.0 2.2 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like DUF333 PF03891.15 PIK50763.1 - 0.11 12.7 0.0 8.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF333) Gal-3-0_sulfotr PF06990.11 PIK50764.1 - 1e-81 274.9 1.0 1.4e-81 274.4 1.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK50764.1 - 3.3e-07 30.5 2.3 3.7e-06 27.1 2.3 2.2 1 1 0 1 1 1 1 Sulfotransferase family Apolipo_F PF15148.6 PIK50764.1 - 0.12 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein F ComGF PF15980.5 PIK50764.1 - 4.5 7.7 7.2 18 5.7 0.1 2.9 3 1 0 3 3 3 0 Putative Competence protein ComGF V-set PF07686.17 PIK50766.1 - 1.8e-05 24.8 1.9 2.2e-05 24.6 0.7 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK50766.1 - 5.4e-05 23.7 5.7 0.0026 18.3 1.4 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK50766.1 - 0.0084 15.9 0.9 0.0084 15.9 0.9 2.1 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 I-set PF07679.16 PIK50766.1 - 0.0098 15.9 0.4 0.027 14.5 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK50766.1 - 0.026 14.9 4.0 0.04 14.2 0.6 2.7 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK50766.1 - 0.046 13.9 6.0 0.76 10.0 3.5 2.9 2 1 0 2 2 2 0 Immunoglobulin domain Glyco_hydro_42M PF08532.10 PIK50766.1 - 0.053 13.0 0.0 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain DUF4792 PF16040.5 PIK50766.1 - 0.13 12.2 0.2 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4792) Vpu PF00558.19 PIK50766.1 - 0.15 11.9 0.2 0.26 11.1 0.2 1.4 1 0 0 1 1 1 0 Vpu protein Ig_4 PF16680.5 PIK50766.1 - 4.4 7.6 8.3 5.6 7.3 1.7 3.5 3 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Glyco_hydro_35 PF01301.19 PIK50767.1 - 1.4e-108 363.3 1.2 4.2e-108 361.7 1.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 PIK50767.1 - 3.3e-14 53.0 0.1 3.5e-13 49.6 0.1 2.4 1 1 1 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 PIK50767.1 - 3.5e-11 43.7 0.3 0.00022 21.7 0.0 2.9 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain Cellulase PF00150.18 PIK50767.1 - 0.099 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Asp PF00026.23 PIK50768.1 - 5.3e-37 127.9 0.1 3.4e-18 66.1 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 PIK50768.1 - 2.5e-09 37.1 0.0 4.2e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 PIK50768.1 - 1.2e-05 25.6 0.0 0.00024 21.4 0.0 2.4 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal FAM176 PF14851.6 PIK50768.1 - 0.29 10.8 1.3 0.33 10.6 0.1 1.6 2 0 0 2 2 2 0 FAM176 family V-set PF07686.17 PIK50769.1 - 3.4e-09 36.8 0.5 1.7e-08 34.6 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK50769.1 - 1.6e-08 34.5 0.0 1.8e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK50769.1 - 4.8e-07 30.3 0.6 0.00089 19.8 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK50769.1 - 8e-06 26.0 1.2 0.064 13.4 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain REJ PF02010.15 PIK50769.1 - 0.00095 18.1 0.1 0.00095 18.1 0.1 1.1 1 0 0 1 1 1 1 REJ domain C1-set PF07654.15 PIK50769.1 - 0.0055 17.0 1.4 0.012 15.9 0.6 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK50769.1 - 0.017 15.2 0.1 0.042 13.9 0.1 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK50770.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.9 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.17 PIK50770.1 - 0.056 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Exo_endo_phos PF03372.23 PIK50772.1 - 0.00037 20.1 0.0 0.00047 19.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK50772.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase GCS PF03074.16 PIK50773.1 - 1.4e-132 442.5 0.0 1.7e-132 442.2 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 PIK50773.1 - 0.089 12.1 0.0 0.53 9.6 0.0 2.0 2 0 0 2 2 2 0 Glutamate-cysteine ligase family 2(GCS2) SCAN PF02023.17 PIK50775.1 - 2.2e-13 49.8 0.0 5.2e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK50775.1 - 1.7e-06 27.9 2.0 3.3e-06 26.9 2.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK50775.1 - 0.0034 17.2 1.4 0.0064 16.3 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF4407 PF14362.6 PIK50775.1 - 2.2 7.5 9.6 0.22 10.8 5.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) rve PF00665.26 PIK50776.1 - 3.6e-17 62.7 0.0 7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK50776.1 - 2.1e-08 34.1 0.6 5.1e-08 32.9 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK50776.1 - 0.002 17.8 0.1 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK50776.1 - 0.06 13.4 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 RT_RNaseH_2 PF17919.1 PIK50777.1 - 2.1e-37 127.2 0.0 4.1e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK50777.1 - 1.6e-35 121.6 0.0 3.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50777.1 - 2.5e-27 95.8 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Calx-beta PF03160.14 PIK50778.1 - 2.7e-12 46.7 0.0 6e-12 45.6 0.0 1.6 2 0 0 2 2 2 1 Calx-beta domain Cadherin_3 PF16184.5 PIK50779.1 - 1.2e-62 208.7 10.0 1.1e-26 93.0 1.7 4.2 4 0 0 4 4 4 3 Cadherin-like Calx-beta PF03160.14 PIK50779.1 - 8.7e-22 77.2 0.5 1.2e-14 54.3 0.1 3.2 2 0 0 2 2 2 2 Calx-beta domain Big_9 PF17963.1 PIK50779.1 - 0.0062 17.3 18.7 0.011 16.4 3.8 4.9 4 2 0 4 4 4 1 Bacterial Ig domain Cadherin_3 PF16184.5 PIK50780.1 - 3e-113 371.7 15.9 1.9e-21 76.1 0.1 6.9 7 0 0 7 7 7 6 Cadherin-like Cadherin_4 PF17803.1 PIK50780.1 - 2.5e-07 31.2 22.9 0.003 18.2 0.5 6.4 6 2 0 6 6 6 2 Bacterial cadherin-like domain Big_9 PF17963.1 PIK50780.1 - 0.0024 18.6 33.0 0.24 12.2 0.7 7.3 5 5 1 6 6 6 4 Bacterial Ig domain Cadherin_3 PF16184.5 PIK50781.1 - 1.1e-41 141.3 1.6 7.3e-16 58.1 0.0 3.2 3 0 0 3 3 3 3 Cadherin-like Furin-like_2 PF15913.5 PIK50781.1 - 4.6e-08 33.2 100.7 0.00076 19.6 21.5 6.3 2 2 5 7 7 7 5 Furin-like repeat, cysteine-rich VSP PF03302.13 PIK50781.1 - 0.00014 20.9 100.9 0.029 13.2 4.2 6.9 2 2 4 6 6 6 5 Giardia variant-specific surface protein VWC PF00093.18 PIK50782.1 - 1e-24 86.6 76.0 7.8e-10 38.9 8.2 4.8 4 1 1 5 5 5 4 von Willebrand factor type C domain CFC PF09443.10 PIK50782.1 - 3.7e-06 26.7 28.0 0.077 12.9 4.1 4.1 3 0 0 3 3 3 3 Cripto_Frl-1_Cryptic (CFC) TILa PF12714.7 PIK50782.1 - 0.0014 18.5 23.6 0.005 16.8 6.9 5.6 1 1 5 6 6 6 3 TILa domain DBC1 PF14443.6 PIK50783.1 - 7.3e-47 158.4 0.0 7.3e-47 158.4 0.0 3.0 3 0 0 3 3 3 1 DBC1 S1-like PF14444.6 PIK50783.1 - 7.4e-30 102.7 0.8 7.4e-30 102.7 0.8 2.3 2 0 0 2 2 2 1 S1-like SAP PF02037.27 PIK50783.1 - 2.7e-10 39.8 1.1 6.2e-10 38.6 1.1 1.7 1 0 0 1 1 1 1 SAP domain ABC2_membrane PF01061.24 PIK50784.1 - 4.2e-27 95.0 27.8 3.9e-26 91.8 17.4 2.5 2 1 1 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 PIK50784.1 - 5.4e-21 75.5 0.0 1e-20 74.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK50784.1 - 1.7e-07 30.7 23.1 1.7e-07 30.7 23.1 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 PIK50784.1 - 7e-05 22.8 0.0 0.055 13.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_2 PF12679.7 PIK50784.1 - 0.00046 19.6 12.7 0.00075 18.9 12.4 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_23 PF13476.6 PIK50784.1 - 0.028 14.9 0.9 0.073 13.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 PIK50784.1 - 0.11 12.8 0.7 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 PIK50785.1 - 1.1e-40 139.3 22.4 1.1e-40 139.3 22.4 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_2 PF12679.7 PIK50785.1 - 3e-05 23.5 7.2 3e-05 23.5 7.2 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC_tran PF00005.27 PIK50785.1 - 7.8e-05 23.2 0.0 0.00035 21.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK50785.1 - 0.0002 20.6 30.6 0.00085 18.5 30.6 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein TMEM95 PF15203.6 PIK50785.1 - 0.0027 17.4 0.1 0.0049 16.5 0.1 1.4 1 0 0 1 1 1 1 TMEM95 family PDR_CDR PF06422.12 PIK50785.1 - 0.046 13.6 0.2 0.046 13.6 0.2 2.7 2 0 0 2 2 2 0 CDR ABC transporter ABC_tran PF00005.27 PIK50786.1 - 6.3e-09 36.5 0.1 1.7e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 PIK50786.1 - 0.00015 22.3 0.7 0.00015 22.3 0.7 1.9 1 1 1 2 2 2 1 AAA domain SMC_N PF02463.19 PIK50786.1 - 0.0013 18.3 0.1 0.0021 17.6 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 PIK50786.1 - 0.0015 18.4 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 PIK50786.1 - 0.023 14.5 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK50786.1 - 0.039 13.7 0.1 0.077 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 PIK50786.1 - 0.12 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC2_membrane PF01061.24 PIK50787.1 - 1e-39 136.1 24.8 1.6e-39 135.5 24.8 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 PIK50787.1 - 1.8e-13 51.2 0.0 3.7e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 PIK50787.1 - 1.1e-07 31.3 20.4 1.7e-07 30.7 20.4 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 PIK50787.1 - 0.0021 17.9 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system TMEM95 PF15203.6 PIK50787.1 - 0.1 12.2 0.4 0.21 11.2 0.4 1.4 1 0 0 1 1 1 0 TMEM95 family ABC2_membrane_2 PF12679.7 PIK50787.1 - 0.47 9.7 13.4 0.035 13.4 8.6 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein IF4E PF01652.18 PIK50788.1 - 6e-53 178.9 0.1 7.5e-53 178.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E FMO-like PF00743.19 PIK50790.1 - 2e-105 353.3 0.3 2.5e-105 352.9 0.3 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK50790.1 - 3.4e-26 92.2 0.3 8.1e-22 77.8 0.1 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK50790.1 - 1.1e-17 64.2 0.1 1.5e-15 57.3 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK50790.1 - 9.2e-13 48.0 0.6 2.6e-11 43.2 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK50790.1 - 4.9e-08 33.1 1.5 8.5e-08 32.3 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK50790.1 - 1e-07 31.9 7.4 0.00089 18.9 1.5 4.1 3 2 0 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK50790.1 - 2.5e-07 29.8 1.6 2.3e-05 23.3 0.5 3.1 2 1 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 PIK50790.1 - 1.4e-06 27.8 5.5 0.00023 20.5 0.4 2.6 3 0 0 3 3 3 2 FAD binding domain Thi4 PF01946.17 PIK50790.1 - 2e-06 27.2 0.8 0.00018 20.8 0.1 2.4 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 PIK50790.1 - 2.9e-05 23.6 2.2 0.004 16.6 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK50790.1 - 4e-05 22.9 2.9 0.0013 17.9 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain IlvN PF07991.12 PIK50790.1 - 0.00012 21.7 0.3 0.01 15.4 0.1 2.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Amino_oxidase PF01593.24 PIK50790.1 - 0.00021 20.8 0.8 0.00081 18.8 0.0 2.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 PIK50790.1 - 0.00028 21.4 4.7 0.076 13.6 0.4 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK50790.1 - 0.0019 18.2 4.4 3.6 7.6 2.2 4.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 PIK50790.1 - 0.0027 17.8 0.5 3.2 7.8 0.0 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 PIK50790.1 - 0.011 14.8 3.3 0.7 8.9 0.1 2.8 4 0 0 4 4 4 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 PIK50790.1 - 0.016 14.8 1.0 0.016 14.8 1.0 1.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 PIK50790.1 - 0.02 14.3 1.1 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 PIK50790.1 - 0.021 13.9 0.4 0.27 10.2 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein GST_C_6 PF17171.4 PIK50790.1 - 0.067 13.0 0.1 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain AlaDh_PNT_C PF01262.21 PIK50790.1 - 0.27 10.5 6.0 0.35 10.1 1.2 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Glyco_transf_10 PF00852.19 PIK50791.1 - 7.9e-37 126.7 0.4 1.3e-36 126.0 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK50791.1 - 2.6e-10 40.7 0.1 3.6e-09 37.0 0.0 2.3 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal OST3_OST6 PF04756.13 PIK50791.1 - 0.031 13.6 1.2 0.85 8.9 0.0 2.5 3 0 0 3 3 3 0 OST3 / OST6 family, transporter family DUF5090 PF17009.5 PIK50791.1 - 0.046 13.7 0.3 0.075 13.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) RINGv PF12906.7 PIK50792.1 - 6.6e-17 61.4 13.4 1.4e-16 60.3 13.4 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 PIK50792.1 - 0.038 14.3 12.9 0.038 14.3 12.9 2.1 2 0 0 2 2 2 0 Ring finger domain VWA_N2 PF16164.5 PIK50792.1 - 0.09 12.9 2.3 0.32 11.2 0.5 2.3 2 0 0 2 2 2 0 VWA N-terminal zf-ANAPC11 PF12861.7 PIK50792.1 - 0.12 12.5 4.0 0.28 11.3 4.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger LRR19-TM PF15176.6 PIK50792.1 - 0.55 10.2 4.3 0.15 12.1 0.4 2.1 1 1 1 2 2 2 0 Leucine-rich repeat family 19 TM domain ROS_MUCR PF05443.11 PIK50793.1 - 0.0022 18.0 0.9 0.027 14.5 0.2 2.5 2 0 0 2 2 2 1 ROS/MUCR transcriptional regulator protein TRAF6_Z2 PF18048.1 PIK50793.1 - 0.016 15.3 1.1 0.046 13.8 1.1 1.8 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 DUF4256 PF14066.6 PIK50793.1 - 0.018 14.7 0.0 0.64 9.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4256) CxC4 PF18717.1 PIK50793.1 - 0.02 14.7 1.6 0.072 12.9 0.0 2.6 2 0 0 2 2 2 0 CxC4 like cysteine cluster associated with KDZ transposases zf-C2H2_12 PF18658.1 PIK50793.1 - 0.17 11.5 6.2 0.14 11.8 0.7 3.3 3 0 0 3 3 3 0 Zinc-finger C2H2-type zf-H2C2_5 PF13909.6 PIK50793.1 - 0.27 11.0 1.7 0.57 10.0 1.1 1.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 PIK50793.1 - 0.52 10.6 7.1 0.25 11.7 2.9 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK50793.1 - 7.9 7.6 12.6 1.2 10.2 2.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger p450 PF00067.22 PIK50794.1 - 2.7e-12 46.2 0.0 3.1e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 XhoI PF04555.13 PIK50794.1 - 0.069 13.1 0.0 0.082 12.8 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease XhoI p450 PF00067.22 PIK50795.1 - 2.5e-77 260.6 0.0 2.9e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK50796.1 - 3.6e-110 368.9 0.0 4.2e-110 368.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC_tran PF00005.27 PIK50797.1 - 2.8e-14 53.8 0.0 3.9e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 PIK50797.1 - 0.0034 17.2 0.0 0.0044 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 PIK50797.1 - 0.19 12.0 0.0 0.55 10.5 0.0 1.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RVT_1 PF00078.27 PIK50798.1 - 3e-42 144.6 0.4 5.9e-42 143.7 0.2 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK50798.1 - 0.046 13.6 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Med18 protein SAM_PNT PF02198.16 PIK50800.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SapA PF02199.15 PIK50801.1 - 1.7e-11 44.2 6.1 7.7e-11 42.1 6.1 2.2 1 0 0 1 1 1 1 Saposin A-type domain SapB_2 PF03489.17 PIK50801.1 - 7.2e-10 38.8 1.9 1.8e-09 37.6 0.2 2.4 2 1 0 2 2 2 1 Saposin-like type B, region 2 SapB_1 PF05184.15 PIK50801.1 - 1.5e-08 34.4 1.8 1.5e-08 34.4 1.8 2.5 3 0 0 3 3 3 1 Saposin-like type B, region 1 SapB_2 PF03489.17 PIK50802.1 - 2e-38 130.2 35.2 5e-14 52.1 0.9 6.7 7 0 0 7 7 7 4 Saposin-like type B, region 2 SapB_1 PF05184.15 PIK50802.1 - 5.7e-23 80.6 26.4 1.1e-06 28.6 0.2 5.9 5 0 0 5 5 5 5 Saposin-like type B, region 1 YqfQ PF14181.6 PIK50802.1 - 0.0037 17.5 0.5 1.7 8.8 0.1 3.3 4 0 0 4 4 4 1 YqfQ-like protein zf-AD PF07776.15 PIK50802.1 - 0.0048 17.1 11.5 7.6 6.9 0.3 4.8 4 1 0 4 4 4 3 Zinc-finger associated domain (zf-AD) DYW_deaminase PF14432.6 PIK50802.1 - 0.019 14.8 7.2 0.54 10.1 0.1 4.3 4 0 0 4 4 4 0 DYW family of nucleic acid deaminases Prp18 PF02840.15 PIK50802.1 - 0.2 11.7 0.1 0.82 9.7 0.0 2.0 2 0 0 2 2 2 0 Prp18 domain SapB_1 PF05184.15 PIK50803.1 - 3.1e-103 337.1 76.9 1.9e-13 50.1 2.1 12.1 11 0 0 11 11 11 10 Saposin-like type B, region 1 SapB_2 PF03489.17 PIK50803.1 - 8.1e-83 272.2 65.3 1.9e-12 47.1 1.2 10.4 9 0 0 9 9 9 9 Saposin-like type B, region 2 SapA PF02199.15 PIK50803.1 - 6.7e-14 51.9 7.6 2.8e-13 49.9 4.9 3.8 3 0 0 3 3 3 1 Saposin A-type domain YdjO PF14169.6 PIK50803.1 - 5.3e-05 22.9 15.6 1.3 8.8 0.5 6.0 5 0 0 5 5 5 4 Cold-inducible protein YdjO P22_AR_C PF10548.9 PIK50803.1 - 0.0002 21.4 0.4 2.8 8.2 0.0 4.1 4 0 0 4 4 4 2 P22AR C-terminal domain Mnd1 PF03962.15 PIK50803.1 - 0.0071 16.6 3.7 19 5.6 0.1 5.0 4 1 0 4 4 4 0 Mnd1 HTH domain RNA_pol_Rpb4 PF03874.16 PIK50803.1 - 0.0084 16.4 0.6 0.052 13.9 0.1 2.7 2 1 0 2 2 2 1 RNA polymerase Rpb4 DUF4359 PF14271.6 PIK50803.1 - 0.014 16.2 26.5 6.7 7.5 0.2 8.5 8 2 0 9 9 9 0 Domain of unknown function (DUF4359) RuvA_C PF07499.13 PIK50803.1 - 0.067 13.7 0.2 18 5.9 0.1 4.5 6 0 0 6 6 6 0 RuvA, C-terminal domain CDT1_C PF16679.5 PIK50803.1 - 0.11 12.9 15.8 4.2 7.9 0.9 6.3 5 2 1 6 6 6 0 DNA replication factor Cdt1 C-terminal domain PIN_5 PF08745.11 PIK50803.1 - 5.9 6.2 6.9 7 6.0 0.1 3.8 3 2 0 4 4 4 0 PINc domain ribonuclease Hemopexin PF00045.19 PIK50804.1 - 7.3e-20 70.7 7.8 2.8e-05 24.0 0.2 4.3 4 0 0 4 4 4 4 Hemopexin Peptidase_M10 PF00413.24 PIK50804.1 - 2.5e-12 46.9 0.1 4.1e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 Matrixin Metallopep PF12044.8 PIK50804.1 - 0.00099 17.8 0.8 0.0021 16.7 0.8 1.5 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 PIK50804.1 - 0.04 12.9 0.4 0.066 12.2 0.4 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M54 PF07998.11 PIK50804.1 - 0.04 13.9 0.1 0.079 12.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M10 PF00413.24 PIK50805.1 - 1.2e-16 60.9 0.6 4.3e-15 55.9 0.6 2.1 1 1 0 1 1 1 1 Matrixin SCP2 PF02036.17 PIK50806.1 - 5e-18 65.5 0.0 8.7e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 PIK50806.1 - 0.021 15.1 0.0 0.056 13.7 0.0 1.6 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal DUF4239 PF14023.6 PIK50807.1 - 0.088 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Glyco_transf_10 PF00852.19 PIK50808.1 - 1.1e-29 103.5 0.0 2.1e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK50808.1 - 6e-14 52.4 0.3 1.1e-13 51.6 0.3 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Sulfotransfer_2 PF03567.14 PIK50809.1 - 2.9e-11 43.7 4.0 4.3e-11 43.2 4.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK50809.1 - 5.7e-06 26.0 0.2 1.7e-05 24.5 0.2 1.8 1 1 0 1 1 1 1 Sulfotransferase domain BRCT PF00533.26 PIK50810.1 - 8.6e-09 35.7 0.0 1.2e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 PIK50810.1 - 0.00031 20.6 0.0 0.00072 19.4 0.0 1.6 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 PIK50810.1 - 0.0024 18.2 0.0 0.0037 17.6 0.0 1.3 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 PIK50810.1 - 0.015 15.2 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 twin BRCT domain Hanta_nucleocap PF00846.18 PIK50810.1 - 0.1 11.0 0.0 0.12 10.8 0.0 1.3 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein DUF3261 PF11659.8 PIK50810.1 - 0.12 12.2 0.9 20 5.0 0.0 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3261) Pkinase PF00069.25 PIK50811.1 - 0.18 11.1 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain DUF3261 PF11659.8 PIK50811.1 - 0.22 11.4 0.8 2.5 8.0 0.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3261) COE1_DBD PF16422.5 PIK50812.1 - 3.2e-118 393.3 0.4 4.2e-118 392.9 0.4 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 PIK50812.1 - 1.8e-30 104.3 0.5 3.4e-30 103.5 0.5 1.5 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 PIK50812.1 - 3.8e-12 46.1 1.4 6.1e-12 45.5 0.2 2.0 2 0 0 2 2 2 1 IPT/TIG domain Cpn60_TCP1 PF00118.24 PIK50813.1 - 8e-48 163.3 0.0 9.2e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ROK PF00480.20 PIK50813.1 - 0.018 14.6 0.0 0.019 14.5 0.0 1.1 1 0 0 1 1 1 0 ROK family Cpn60_TCP1 PF00118.24 PIK50814.1 - 2.5e-19 69.3 0.0 3.1e-19 69.0 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 PIK50815.1 - 6.4e-58 196.6 1.7 7.9e-58 196.3 1.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MRP-S26 PF14943.6 PIK50816.1 - 1.4e-44 152.0 14.6 1.4e-44 152.0 14.6 1.8 2 0 0 2 2 2 1 Mitochondrial ribosome subunit S26 Iron_permease PF04120.12 PIK50816.1 - 0.1 12.4 0.6 0.1 12.4 0.6 2.1 1 1 1 2 2 2 0 Low affinity iron permease DNA_binding_1 PF01035.20 PIK50817.1 - 2.9e-27 94.6 0.0 4.9e-27 93.9 0.0 1.4 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DNA_binding_1 PF01035.20 PIK50818.1 - 2.1e-25 88.7 0.0 2.9e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 PIK50818.1 - 0.17 12.7 0.0 0.32 11.8 0.0 1.4 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain ENTH PF01417.20 PIK50819.1 - 2.4e-36 124.5 0.3 4e-36 123.8 0.3 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 PIK50819.1 - 0.0017 17.4 0.0 0.0063 15.5 0.0 1.8 2 0 0 2 2 2 1 ANTH domain Ion_trans_2 PF07885.16 PIK50822.1 - 1.6e-33 114.5 25.2 1.1e-19 70.2 5.4 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 PIK50822.1 - 4.4e-11 42.5 5.6 1.4e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 PIK50822.1 - 0.014 15.2 9.0 0.066 13.0 0.4 3.0 3 0 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain DUF2101 PF09874.9 PIK50822.1 - 6.1 6.5 10.2 0.39 10.4 4.5 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) DUF1090 PF06476.12 PIK50822.1 - 9 6.5 6.7 3.8 7.7 3.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) MULE PF10551.9 PIK50824.1 - 1.2e-07 32.0 0.0 4.4e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 MULE transposase domain tRNA-synt_2e PF02091.15 PIK50824.1 - 0.039 13.2 0.1 0.089 12.0 0.0 1.6 2 0 0 2 2 2 0 Glycyl-tRNA synthetase alpha subunit NBP1 PF08537.10 PIK50827.1 - 0.002 17.6 8.8 0.003 17.1 8.8 1.2 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 AAA_13 PF13166.6 PIK50827.1 - 0.17 10.5 11.9 0.21 10.2 11.9 1.1 1 0 0 1 1 1 0 AAA domain LOH1CR12 PF10158.9 PIK50827.1 - 0.32 11.0 7.6 0.16 12.0 4.0 2.0 1 1 1 2 2 2 0 Tumour suppressor protein DUF948 PF06103.11 PIK50827.1 - 0.64 10.3 3.5 22 5.4 1.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 PIK50827.1 - 1.1 9.5 23.3 0.31 11.3 9.8 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Rubis-subs-bind PF09273.11 PIK50827.1 - 1.1 9.9 7.6 2.4 8.8 7.4 1.8 1 1 0 1 1 1 0 Rubisco LSMT substrate-binding DUF4200 PF13863.6 PIK50827.1 - 3.4 8.1 18.5 4 7.9 17.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) KxDL PF10241.9 PIK50827.1 - 4.6 7.6 18.1 0.11 12.8 2.2 3.0 2 1 0 3 3 3 0 Uncharacterized conserved protein TMCO5 PF14992.6 PIK50827.1 - 9.5 5.7 16.2 16 5.0 16.2 1.3 1 1 0 1 1 1 0 TMCO5 family SlyX PF04102.12 PIK50827.1 - 9.6 6.9 14.8 5.8 7.6 2.7 4.2 2 1 1 4 4 4 0 SlyX Integrase_H2C2 PF17921.1 PIK50828.1 - 4.8e-17 61.8 0.6 9.4e-17 60.9 0.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK50828.1 - 4.3e-14 52.7 0.0 7.3e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50828.1 - 0.0039 16.9 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK50828.1 - 0.041 14.1 0.1 0.09 13.0 0.1 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Retrotran_gag_2 PF14223.6 PIK50828.1 - 0.06 13.0 0.3 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Mut7-C PF01927.16 PIK50828.1 - 0.16 12.1 3.8 11 6.2 0.2 3.1 2 1 1 3 3 3 0 Mut7-C RNAse domain RVT_1 PF00078.27 PIK50829.1 - 5e-24 85.0 0.0 1.2e-23 83.9 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK50830.1 - 3.8e-25 88.7 0.0 6.8e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cornifin PF02389.15 PIK50831.1 - 1 9.5 11.4 19 5.4 4.3 2.5 1 1 1 2 2 2 0 Cornifin (SPRR) family HTH_40 PF14493.6 PIK50832.1 - 0.023 15.2 0.1 0.05 14.1 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Pox_RNA_Pol_19 PF05320.12 PIK50832.1 - 0.16 12.0 4.2 0.27 11.2 4.2 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CDC37_C PF08564.10 PIK50832.1 - 0.96 9.6 0.0 0.96 9.6 0.0 2.6 2 1 0 2 2 2 0 Cdc37 C terminal domain rve PF00665.26 PIK50833.1 - 2.3e-13 50.4 0.0 3.1e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK50833.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain malic PF00390.19 PIK50834.1 - 4e-74 248.4 0.0 6e-74 247.8 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 PIK50834.1 - 5.1e-67 225.9 0.8 8.6e-58 195.6 0.0 2.1 1 1 1 2 2 2 2 Malic enzyme, NAD binding domain Bromodomain PF00439.25 PIK50835.1 - 2e-56 188.0 9.2 1.1e-17 63.9 0.1 4.5 4 0 0 4 4 4 4 Bromodomain WD40 PF00400.32 PIK50836.1 - 8.4e-32 108.7 14.5 1.8e-05 25.4 0.2 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat Bromodomain PF00439.25 PIK50836.1 - 6.2e-18 64.7 1.7 2.7e-12 46.6 0.1 2.6 2 0 0 2 2 2 2 Bromodomain ANAPC4_WD40 PF12894.7 PIK50836.1 - 6.2e-08 32.8 0.1 0.46 10.8 0.3 5.5 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK50836.1 - 1.3e-05 24.1 3.3 0.0067 15.1 0.1 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Auxin_resp PF06507.13 PIK50836.1 - 0.018 15.3 0.1 0.092 13.0 0.0 2.2 2 0 0 2 2 2 0 Auxin response factor Prenyltransf PF01255.19 PIK50837.1 - 1.9e-77 259.8 0.1 2.7e-77 259.3 0.1 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF3626 PF12294.8 PIK50837.1 - 0.029 13.4 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) AATase PF07247.12 PIK50837.1 - 0.06 11.9 0.1 0.097 11.2 0.1 1.2 1 0 0 1 1 1 0 Alcohol acetyltransferase Ten1_2 PF15490.6 PIK50837.1 - 0.094 12.4 0.0 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 Telomere-capping, CST complex subunit SKA2 PF16740.5 PIK50837.1 - 1.7 8.5 6.1 0.68 9.7 1.9 2.2 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Exo_endo_phos PF03372.23 PIK50838.1 - 1.6e-18 67.1 0.0 1.9e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK50838.1 - 0.00026 20.8 0.0 0.0022 17.9 0.0 2.2 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Lipase_GDSL_3 PF14606.6 PIK50838.1 - 0.1 12.7 0.0 20 5.2 0.0 2.4 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Ribosomal_L19 PF01245.20 PIK50839.1 - 0.00078 19.4 0.2 0.0017 18.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L19 zf-UBP PF02148.19 PIK50840.1 - 4.7e-19 68.5 5.1 8.6e-19 67.6 5.1 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein GMC_oxred_C PF05199.13 PIK50840.1 - 0.086 13.4 0.4 0.5 10.9 0.4 1.9 1 1 0 1 1 1 0 GMC oxidoreductase PhnA_Zn_Ribbon PF08274.12 PIK50840.1 - 0.23 11.4 4.0 2.8 8.0 4.0 2.5 1 1 0 1 1 1 0 PhnA Zinc-Ribbon UCH PF00443.29 PIK50841.1 - 9.8e-25 87.5 1.0 5.7e-18 65.3 0.2 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Fibritin_C PF07921.12 PIK50842.1 - 0.026 14.6 0.1 0.03 14.4 0.1 1.1 1 0 0 1 1 1 0 Fibritin C-terminal region RRM_1 PF00076.22 PIK50843.1 - 2.1e-13 49.9 0.0 1.4e-12 47.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_8 PF08022.12 PIK50845.1 - 2.4e-17 63.0 0.0 5.7e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 PIK50845.1 - 5.6e-17 62.3 0.0 1.7e-16 60.7 0.0 1.9 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 PIK50845.1 - 8.4e-14 51.8 1.2 2.1e-13 50.5 1.2 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 PIK50845.1 - 0.019 15.3 0.0 0.046 14.1 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 PIK50845.1 - 0.076 13.7 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Ni_hydr_CYTB PF01292.20 PIK50845.1 - 0.44 10.1 2.2 1.1 8.8 1.7 2.0 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Peptidase_M50B PF13398.6 PIK50845.1 - 0.73 9.4 10.1 1.2 8.7 3.4 2.8 3 0 0 3 3 3 0 Peptidase M50B-like Pyr_redox_2 PF07992.14 PIK50846.1 - 6.5e-31 107.6 0.1 8.5e-18 64.6 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 PIK50846.1 - 9.7e-08 31.8 0.2 2.8e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 PIK50846.1 - 0.00018 22.0 0.7 0.21 12.2 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK50846.1 - 0.00032 20.7 0.2 3.7 7.5 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 PIK50846.1 - 0.0047 16.1 0.1 2.3 7.3 0.1 2.1 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 PIK50846.1 - 0.01 15.4 0.4 0.098 12.2 0.2 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK50846.1 - 0.072 12.3 1.9 16 4.7 0.0 3.1 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK50846.1 - 0.096 11.7 0.8 2.3 7.2 0.2 2.5 3 0 0 3 3 3 0 FAD binding domain GIDA PF01134.22 PIK50846.1 - 0.51 9.4 4.8 6 5.8 0.0 2.3 1 1 1 2 2 2 0 Glucose inhibited division protein A SIMPL PF04402.14 PIK50847.1 - 6e-22 79.1 0.0 7.1e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) SCO1-SenC PF02630.14 PIK50847.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 SCO1/SenC Jagunal PF07086.12 PIK50848.1 - 1.6e-36 126.2 0.1 1.9e-36 125.9 0.1 1.1 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis Seadorna_Vp10 PF07322.11 PIK50848.1 - 0.09 12.2 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus Vp10 Sugar_tr PF00083.24 PIK50849.1 - 9.5e-30 103.8 8.8 7e-21 74.6 3.1 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK50849.1 - 3.2e-20 72.3 31.9 1.7e-12 46.9 18.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 PIK50849.1 - 0.01 14.2 10.6 0.0026 16.1 7.4 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2977 PF11192.8 PIK50849.1 - 0.16 12.1 0.1 0.36 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2977) MFS_1 PF07690.16 PIK50851.1 - 6.5e-25 87.8 15.2 8.3e-25 87.4 15.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily RVT_1 PF00078.27 PIK50851.1 - 5.2e-09 36.0 0.0 1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TssO PF17561.2 PIK50851.1 - 0.028 14.5 6.5 0.29 11.2 0.5 3.0 3 0 0 3 3 3 0 Type VI secretion system, TssO Geminin PF07412.12 PIK50851.1 - 0.085 12.6 1.4 0.18 11.5 1.4 1.4 1 0 0 1 1 1 0 Geminin MBT PF02820.18 PIK50852.1 - 3e-41 139.6 0.0 2e-27 95.3 0.0 2.2 2 0 0 2 2 2 2 mbt repeat DHC_N1 PF08385.12 PIK50853.1 - 3.2e-184 613.7 4.8 3.2e-184 613.7 4.8 3.3 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 PIK50853.1 - 1.9e-146 487.2 0.0 1.4e-145 484.4 0.0 2.5 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK50853.1 - 5.5e-125 417.6 4.0 5.5e-125 417.6 4.0 3.5 3 2 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 PIK50853.1 - 4.3e-69 231.6 1.0 1.1e-63 214.1 0.2 3.8 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_5 PF07728.14 PIK50853.1 - 1.7e-18 67.0 0.0 3.4e-07 30.3 0.0 4.1 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 PIK50853.1 - 9.2e-15 54.9 0.6 9.7e-14 51.6 0.1 3.2 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA PF00004.29 PIK50853.1 - 1.2e-06 29.0 0.1 0.38 11.2 0.0 4.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK50853.1 - 0.00037 20.8 0.9 8.1 6.7 0.0 4.3 4 0 0 4 4 3 1 AAA domain AAA_16 PF13191.6 PIK50853.1 - 0.00083 19.8 0.0 6 7.2 0.0 4.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 PIK50853.1 - 0.038 14.2 2.2 59 3.8 0.0 4.9 5 0 0 5 5 5 0 AAA domain AAA_30 PF13604.6 PIK50853.1 - 0.052 13.3 2.6 43 3.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 PIK50853.1 - 0.056 14.0 0.1 8.4 7.0 0.0 3.5 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 PIK50853.1 - 0.059 13.8 0.3 23 5.4 0.0 3.6 4 0 0 4 4 4 0 RNA helicase Csm2_III-A PF03750.13 PIK50853.1 - 1 10.2 4.3 1.2 10.0 0.1 3.4 3 0 0 3 3 2 0 Csm2 Type III-A GIDA_assoc PF13932.6 PIK50853.1 - 3.5 7.8 7.8 0.27 11.4 0.2 3.1 3 0 0 3 3 3 0 GidA associated domain Dynein_C PF18199.1 PIK50854.1 - 4.4e-99 331.6 4.8 9.5e-99 330.5 0.0 3.0 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 PIK50854.1 - 9.9e-94 313.5 0.0 2.1e-93 312.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK50854.1 - 6.9e-74 247.7 2.9 3.4e-72 242.1 0.8 3.4 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK50854.1 - 1.5e-56 190.8 0.1 2.9e-56 189.8 0.1 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 PIK50854.1 - 1.9e-45 155.4 6.4 1.9e-45 155.4 6.4 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 PIK50854.1 - 2.1e-43 147.2 0.6 1.1e-42 144.9 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 PIK50854.1 - 3e-14 53.1 0.0 1.3e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain Cut12 PF11500.8 PIK50854.1 - 0.084 12.8 1.3 0.26 11.2 1.3 1.8 1 0 0 1 1 1 0 Spindle pole body formation-associated protein AAA_5 PF07728.14 PIK50854.1 - 0.096 12.7 0.0 0.3 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) UPF0242 PF06785.11 PIK50854.1 - 0.95 9.5 14.7 0.98 9.5 0.1 3.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Borrelia_P83 PF05262.11 PIK50854.1 - 7.8 4.9 17.7 4.6 5.6 7.3 2.3 2 0 0 2 2 2 0 Borrelia P83/100 protein DUF4407 PF14362.6 PIK50854.1 - 9.4 5.5 16.7 2.8 7.2 1.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) PAC1 PF16094.5 PIK50855.1 - 1.1e-56 192.2 0.6 2.5e-56 191.0 0.6 1.6 1 1 0 1 1 1 1 Proteasome assembly chaperone 4 PAC2 PF09754.9 PIK50855.1 - 0.0011 19.1 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 PAC2 family DUF3827 PF12877.7 PIK50855.1 - 0.04 12.3 0.0 0.051 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Hydrolase_3 PF08282.12 PIK50857.1 - 0.049 13.4 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK50858.1 - 2.2e-20 73.9 0.1 2.5e-20 73.7 0.1 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 PIK50858.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 PIK50859.1 - 1.4e-38 132.2 2.1 1.9e-38 131.8 0.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 PIK50859.1 - 1.5e-30 105.4 0.3 3.1e-13 50.0 0.0 3.6 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase PF00702.26 PIK50859.1 - 8.9e-09 35.9 0.1 2e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase zf-LITAF-like PF10601.9 PIK50859.1 - 7.2 7.0 7.3 2 8.8 0.1 3.1 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain PAP2 PF01569.21 PIK50860.1 - 2.4e-28 98.6 1.8 3.8e-28 98.0 1.8 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 PIK50860.1 - 0.00052 19.8 1.3 0.0015 18.2 1.3 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 PIK50860.1 - 0.011 16.2 1.1 0.011 16.2 1.1 1.8 2 0 0 2 2 2 0 PAP2 superfamily C-terminal CAAD PF14159.6 PIK50860.1 - 0.034 14.0 2.8 0.33 10.8 0.7 2.4 1 1 1 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase COX7a PF02238.15 PIK50860.1 - 0.17 12.3 4.8 0.39 11.1 0.2 3.1 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VII GIDA_assoc PF13932.6 PIK50861.1 - 1.1e-05 25.7 0.1 1.7e-05 25.1 0.1 1.2 1 0 0 1 1 1 1 GidA associated domain GIDA PF01134.22 PIK50862.1 - 1.3e-146 488.8 0.0 1.7e-146 488.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 PIK50862.1 - 6.2e-42 144.2 0.0 9.2e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 PIK50862.1 - 3.4e-06 26.7 0.5 6.5e-06 25.8 0.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK50862.1 - 3.6e-05 23.0 2.4 0.00031 20.0 1.7 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK50862.1 - 0.00016 21.0 0.6 0.0006 19.1 0.1 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK50862.1 - 0.00031 19.6 0.7 0.025 13.3 0.2 2.4 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 PIK50862.1 - 0.0034 17.9 0.4 0.0088 16.6 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 PIK50862.1 - 0.015 14.6 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TolA PF06519.11 PIK50862.1 - 0.033 14.4 0.2 1.3 9.3 0.1 2.9 3 0 0 3 3 3 0 TolA C-terminal Lycopene_cycl PF05834.12 PIK50862.1 - 0.057 12.5 1.0 0.21 10.6 0.4 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 PIK50862.1 - 0.16 11.2 0.0 0.4 9.9 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK50862.1 - 0.26 11.6 0.9 0.71 10.1 0.9 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DSPc PF00782.20 PIK50864.1 - 2.6e-22 79.1 0.0 3.9e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK50864.1 - 2.4e-08 34.5 0.0 5.7e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Init_tRNA_PT PF04179.12 PIK50864.1 - 0.0028 18.0 0.0 0.0068 16.7 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain 2OG-FeII_Oxy PF03171.20 PIK50865.1 - 2.1e-05 24.9 0.0 4.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 PIK50865.1 - 2.4e-05 24.6 0.0 3.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LRR_8 PF13855.6 PIK50866.1 - 1.1e-12 47.5 10.9 8.1e-10 38.3 5.5 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK50866.1 - 2.8e-12 46.6 12.8 4.4e-07 30.1 3.3 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK50866.1 - 5.7e-05 22.7 5.3 9.5e-05 22.0 3.6 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK50866.1 - 0.024 15.1 16.8 0.42 11.4 0.4 4.9 4 2 1 5 5 5 0 Leucine Rich Repeat Sial-lect-inser PF09264.10 PIK50866.1 - 0.059 13.1 0.1 0.12 12.1 0.1 1.5 1 1 0 1 1 1 0 Vibrio cholerae sialidase, lectin insertion Phage_TAC_4 PF08748.11 PIK50866.1 - 0.059 13.7 0.3 0.11 12.8 0.3 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone Msap1 PF17077.5 PIK50866.1 - 0.066 12.4 0.1 0.085 12.0 0.1 1.1 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 LRR_6 PF13516.6 PIK50866.1 - 2.3 8.5 9.9 12 6.3 0.1 4.3 4 0 0 4 4 4 0 Leucine Rich repeat Rrn6 PF10214.9 PIK50867.1 - 4.4 5.7 9.1 4.5 5.6 9.1 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Mito_fiss_reg PF05308.11 PIK50867.1 - 8.5 6.4 14.6 10 6.1 14.6 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator WD40 PF00400.32 PIK50868.1 - 0.00014 22.5 15.0 5 8.2 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50868.1 - 0.00067 19.9 1.3 13 6.1 0.0 3.8 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain RabGAP-TBC PF00566.18 PIK50869.1 - 8.9e-40 136.6 1.8 2e-39 135.5 1.8 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 PIK50869.1 - 6.9e-30 104.3 0.0 1.3e-29 103.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50869.1 - 1.2e-16 60.8 0.0 2.5e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 PIK50869.1 - 2.7e-12 47.1 0.0 8.6e-12 45.5 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Kinase-like PF14531.6 PIK50869.1 - 0.00021 20.7 0.0 0.00043 19.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DUF1409 PF07197.12 PIK50870.1 - 0.029 14.2 0.1 0.06 13.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) EMP24_GP25L PF01105.24 PIK50871.1 - 2.6e-47 161.1 0.1 3.2e-47 160.8 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DnaB_C PF03796.15 PIK50871.1 - 0.032 13.6 0.0 0.051 12.9 0.0 1.3 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain DEAD PF00270.29 PIK50872.1 - 1.2e-41 142.4 0.0 2.6e-41 141.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK50872.1 - 6.8e-22 77.9 0.1 4.1e-21 75.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK50872.1 - 3.3e-19 68.9 1.0 8e-19 67.6 0.2 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4217) ResIII PF04851.15 PIK50872.1 - 4e-06 26.9 0.0 9.1e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 PIK50872.1 - 0.15 12.2 0.9 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 Helicase C-terminal domain ALO PF04030.14 PIK50873.1 - 3.3e-13 50.1 1.2 3.7e-13 49.9 1.2 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase TPMT PF05724.11 PIK50874.1 - 6.4e-39 133.9 0.0 8.1e-39 133.5 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 PIK50874.1 - 6.2e-05 23.6 0.0 0.00013 22.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK50874.1 - 0.002 18.8 0.0 0.02 15.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain 7TM_GPCR_Srw PF10324.9 PIK50874.1 - 0.03 13.6 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw RT_RNaseH PF17917.1 PIK50875.1 - 2.8e-36 124.0 0.0 6.2e-36 122.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK50875.1 - 7.1e-33 112.6 0.0 2e-32 111.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50875.1 - 5e-26 91.6 0.1 8.1e-26 90.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cystatin PF00031.21 PIK50876.1 - 4.3e-08 33.3 0.1 5e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 Cystatin domain ALMT PF11744.8 PIK50877.1 - 0.8 8.5 5.6 0.96 8.2 5.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DER1 PF04511.15 PIK50878.1 - 1.9e-27 96.5 0.7 2.2e-27 96.2 0.7 1.1 1 0 0 1 1 1 1 Der1-like family DER1 PF04511.15 PIK50879.1 - 5.8e-62 209.0 13.2 8.1e-62 208.5 13.2 1.2 1 0 0 1 1 1 1 Der1-like family MCLC PF05934.11 PIK50879.1 - 0.32 9.7 4.1 0.41 9.3 4.1 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) TUDOR PF00567.24 PIK50880.1 - 2.5e-35 121.2 1.3 5.6e-15 55.4 0.2 4.4 3 1 1 4 4 4 3 Tudor domain DEAD PF00270.29 PIK50880.1 - 6.6e-10 39.0 0.0 1.7e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase CS PF04969.16 PIK50880.1 - 1.5e-05 25.9 0.3 5.1e-05 24.2 0.3 2.0 1 0 0 1 1 1 1 CS domain Helicase_C PF00271.31 PIK50880.1 - 0.00076 19.8 0.0 0.0023 18.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Agenet PF05641.12 PIK50880.1 - 0.0037 17.7 0.1 1.8 9.1 0.0 2.8 2 0 0 2 2 2 2 Agenet domain PhageMin_Tail PF10145.9 PIK50881.1 - 0.13 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein RVT_1 PF00078.27 PIK50882.1 - 3e-18 66.2 0.0 4.6e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_int_SAM_1 PF02899.17 PIK50882.1 - 0.00021 21.5 0.8 0.00065 20.0 0.1 2.2 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK50882.1 - 0.00081 19.8 0.0 0.0017 18.8 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK50882.1 - 0.0019 18.0 0.0 0.0056 16.5 0.0 1.7 1 1 0 1 1 1 1 Phage integrase family RecR PF02132.15 PIK50883.1 - 0.0063 16.1 2.9 0.013 15.1 2.9 1.5 1 0 0 1 1 1 1 RecR protein Atrophin-1 PF03154.15 PIK50883.1 - 0.032 12.6 9.7 0.036 12.4 9.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family eIF3g PF12353.8 PIK50883.1 - 0.12 12.7 3.3 0.17 12.2 3.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G DUF3736 PF12540.8 PIK50884.1 - 8.5e-19 68.0 4.7 8.5e-19 68.0 4.7 5.7 5 1 0 6 6 6 1 Protein of unknown function (DUF3736) DUF2250 PF10007.9 PIK50884.1 - 1 9.6 5.6 2 8.6 0.7 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) Sld5 PF05916.11 PIK50885.1 - 1.8e-20 73.4 0.8 2.4e-20 73.0 0.8 1.2 1 0 0 1 1 1 1 GINS complex protein NACHT PF05729.12 PIK50886.1 - 1.4e-10 41.3 0.0 2.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK50886.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF1242 PF06842.12 PIK50887.1 - 7.2e-19 67.3 1.6 1.1e-18 66.8 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Chromo_2 PF18704.1 PIK50888.1 - 1.5e-06 28.3 0.0 6.8e-06 26.3 0.0 2.2 1 0 0 1 1 1 1 Chromatin organization modifier domain 2 XPG_I PF00867.18 PIK50889.1 - 4.4e-23 81.4 0.1 7e-23 80.8 0.1 1.3 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 PIK50889.1 - 4e-14 52.9 0.0 2.1e-13 50.6 0.0 2.0 1 1 1 2 2 2 1 XPG N-terminal domain WHIM1 PF15612.6 PIK50890.1 - 5.5e-09 35.4 0.3 5.5e-09 35.4 0.3 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDT PF02791.17 PIK50890.1 - 4.6e-06 26.8 0.1 1.2e-05 25.5 0.1 1.7 2 0 0 2 2 2 1 DDT domain WSD PF15613.6 PIK50891.1 - 1.6e-09 38.2 0.4 1.7e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Clc-like PF07062.12 PIK50891.1 - 0.093 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Clc-like FAM176 PF14851.6 PIK50892.1 - 0.023 14.4 4.3 0.027 14.1 4.3 1.1 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 PIK50892.1 - 0.036 13.9 1.5 0.035 13.9 1.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4820 PF16091.5 PIK50892.1 - 0.11 11.8 3.0 0.13 11.6 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RXT2_N PF08595.11 PIK50892.1 - 0.4 10.7 5.3 0.47 10.5 5.3 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 PIK50892.1 - 1 8.4 6.5 1.1 8.3 6.5 1.0 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CDC45 PF02724.14 PIK50892.1 - 1.2 7.3 6.2 1.2 7.3 6.2 1.0 1 0 0 1 1 1 0 CDC45-like protein S-antigen PF05756.11 PIK50892.1 - 1.3 9.4 5.7 2.1 8.8 5.7 1.4 1 0 0 1 1 1 0 S-antigen protein DNA_pol_phi PF04931.13 PIK50892.1 - 1.5 6.8 11.1 1.6 6.7 11.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 PIK50892.1 - 4.7 5.3 10.2 5.3 5.1 10.2 1.0 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 PIK50892.1 - 6.4 7.2 12.5 9.3 6.7 12.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Na_Ca_ex PF01699.24 PIK50893.1 - 6.1e-09 36.0 1.7 6.1e-09 36.0 1.7 2.2 2 0 0 2 2 2 1 Sodium/calcium exchanger protein DUF2070 PF09843.9 PIK50893.1 - 0.018 13.3 2.9 0.021 13.2 2.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fumarate_red_D PF02313.17 PIK50893.1 - 0.094 12.8 3.0 4.8 7.3 0.0 2.6 1 1 0 2 2 2 0 Fumarate reductase subunit D MerC PF03203.14 PIK50893.1 - 0.15 12.5 4.7 0.27 11.7 4.7 1.4 1 0 0 1 1 1 0 MerC mercury resistance protein Ank_2 PF12796.7 PIK50894.1 - 1.5e-26 92.8 0.3 1.1e-13 51.5 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK50894.1 - 2.5e-18 65.9 2.0 1.5e-07 31.5 0.1 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK50894.1 - 4.6e-14 52.6 4.5 6e-06 26.7 0.3 4.6 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK50894.1 - 3.2e-12 45.5 2.1 0.0032 17.9 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 PIK50894.1 - 5.2e-12 45.6 5.6 0.032 14.7 0.1 5.5 5 0 0 5 5 5 3 Ankyrin repeat Metallophos PF00149.28 PIK50895.1 - 1.9e-39 136.3 0.1 2.4e-39 135.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK50895.1 - 1.8e-17 63.5 0.3 4.8e-17 62.1 0.1 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain DUF1168 PF06658.12 PIK50896.1 - 8.6e-44 148.7 22.9 8.6e-44 148.7 22.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) CNDH2_C PF16858.5 PIK50896.1 - 0.026 14.4 17.4 0.039 13.8 14.3 2.0 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4407 PF14362.6 PIK50896.1 - 0.56 9.5 6.5 0.57 9.5 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atrophin-1 PF03154.15 PIK50896.1 - 0.73 8.0 10.4 0.82 7.9 10.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family SAPS PF04499.15 PIK50896.1 - 0.82 8.4 8.7 0.76 8.5 8.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PPL5 PF18168.1 PIK50896.1 - 1.3 8.3 11.9 2.1 7.6 11.9 1.3 1 0 0 1 1 1 0 Prim-pol family 5 PBP_sp32 PF07222.12 PIK50896.1 - 1.5 8.2 8.6 1.8 8.0 8.6 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 XRN_M PF17846.1 PIK50896.1 - 3.8 6.4 14.3 6 5.7 14.3 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Ion_trans PF00520.31 PIK50897.1 - 1.1e-07 31.3 2.5 1.6e-07 30.9 2.5 1.1 1 0 0 1 1 1 1 Ion transport protein DUF641 PF04859.12 PIK50897.1 - 0.022 15.1 1.0 0.065 13.6 0.7 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Spb1_C PF07780.12 PIK50898.1 - 2.6e-62 210.2 19.7 3.7e-62 209.7 19.7 1.2 1 0 0 1 1 1 1 Spb1 C-terminal domain FtsJ PF01728.19 PIK50899.1 - 6.1e-41 140.5 0.3 3.8e-31 108.6 0.0 2.6 1 1 1 2 2 2 2 FtsJ-like methyltransferase DUF3381 PF11861.8 PIK50899.1 - 6e-34 117.2 14.8 6e-34 117.2 14.8 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3381) eIF-3c_N PF05470.12 PIK50900.1 - 3.2e-107 359.3 27.4 3.2e-107 359.3 27.4 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Plasmodium_Vir PF05795.11 PIK50900.1 - 0.68 9.3 24.9 0.01 15.3 8.1 2.7 2 1 0 2 2 2 0 Plasmodium vivax Vir protein eIF-3c_N PF05470.12 PIK50901.1 - 5.9e-87 292.4 9.3 5.9e-87 292.4 9.3 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 PIK50901.1 - 9.2e-14 51.8 0.1 2.3e-13 50.5 0.1 1.7 1 0 0 1 1 1 1 PCI domain Methyltransf_10 PF05971.12 PIK50902.1 - 3.4e-90 302.4 0.0 5.6e-90 301.7 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase PrmA PF06325.13 PIK50902.1 - 0.00035 20.1 0.0 0.00068 19.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 PIK50902.1 - 0.0038 16.8 0.0 0.0082 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 PIK50902.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein ALMT PF11744.8 PIK50902.1 - 0.55 9.0 3.1 0.99 8.2 3.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SCAN PF02023.17 PIK50903.1 - 3.2e-13 49.3 0.1 8.5e-13 47.9 0.1 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC_3 PF13917.6 PIK50903.1 - 0.011 15.7 1.1 0.011 15.7 1.1 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 PIK50903.1 - 0.012 15.6 0.5 0.023 14.8 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle ROS_MUCR PF05443.11 PIK50903.1 - 0.059 13.4 0.3 3.1 7.8 0.1 2.8 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein gag-asp_proteas PF13975.6 PIK50903.1 - 0.13 12.8 0.0 0.56 10.8 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 PIK50904.1 - 5.8e-16 58.7 0.1 7e-16 58.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 PIK50905.1 - 3.1e-39 132.3 9.3 5.8e-09 36.4 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50905.1 - 1.7e-12 47.4 1.1 0.00041 20.6 0.0 3.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK50905.1 - 3.8e-07 29.1 4.0 0.12 11.0 0.0 4.0 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 PIK50905.1 - 7.1e-05 21.9 1.6 0.058 12.3 0.1 3.6 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH PF08513.11 PIK50905.1 - 0.0014 18.5 0.1 0.003 17.5 0.1 1.6 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.11 PIK50905.1 - 0.0015 17.4 0.2 0.1 11.3 0.0 2.5 1 1 1 2 2 2 1 Nup133 N terminal like Pox_A_type_inc PF04508.12 PIK50905.1 - 0.0035 17.1 0.3 0.0093 15.8 0.3 1.8 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat eIF2A PF08662.11 PIK50905.1 - 0.0064 16.4 0.2 0.042 13.7 0.1 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A LisH_2 PF16045.5 PIK50905.1 - 0.012 14.6 0.0 0.027 13.5 0.0 1.6 1 0 0 1 1 1 0 LisH WD40 PF00400.32 PIK50906.1 - 3.8e-20 71.8 0.8 8.5e-09 35.9 0.4 2.1 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK50906.1 - 1.3e-05 25.4 0.0 1.5e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK50906.1 - 0.0044 15.7 0.1 0.0079 14.9 0.0 1.4 1 1 1 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK50906.1 - 0.0063 16.4 0.0 0.0069 16.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A CLU PF13236.6 PIK50907.1 - 2.5e-62 210.6 0.0 2.1e-31 109.5 0.0 2.9 1 1 1 2 2 2 2 Clustered mitochondria TPR_12 PF13424.6 PIK50907.1 - 1.1e-23 83.3 2.9 1.2e-09 38.3 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat eIF3_p135 PF12807.7 PIK50907.1 - 3.6e-22 79.2 1.6 2.2e-14 53.9 0.2 4.0 2 2 1 3 3 2 2 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 PIK50907.1 - 1.5e-15 57.3 0.0 4e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 PIK50907.1 - 5.1e-09 35.7 1.5 0.00049 19.9 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF727 PF05303.12 PIK50907.1 - 8.9e-07 28.9 0.1 4.1e-06 26.8 0.1 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_MalT PF17874.1 PIK50907.1 - 0.00053 19.5 1.0 0.0014 18.1 0.1 2.1 2 1 0 2 2 2 1 MalT-like TPR region TPR_2 PF07719.17 PIK50907.1 - 0.022 14.9 0.1 2.9 8.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK50907.1 - 0.044 13.6 0.0 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK50907.1 - 0.1 12.9 0.1 7.1 7.1 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4337 PF14235.6 PIK50907.1 - 5 7.2 5.5 5.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) LRAT PF04970.13 PIK50908.1 - 4.5e-12 46.4 2.0 6.4e-11 42.6 2.0 2.3 1 1 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK50908.1 - 0.027 14.3 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 PPPDE putative peptidase domain RVT_1 PF00078.27 PIK50909.1 - 0.016 14.7 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Cyt_b-c1_8 PF10890.8 PIK50910.1 - 0.14 12.6 0.2 0.27 11.6 0.2 1.5 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Flavodoxin_1 PF00258.25 PIK50911.1 - 3.7e-23 82.3 0.0 5e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin Transketolase_C PF02780.20 PIK50911.1 - 0.0053 16.6 0.0 0.0084 16.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain Tetraspanin PF00335.20 PIK50911.1 - 0.11 12.2 1.7 0.2 11.3 1.7 1.5 1 1 0 1 1 1 0 Tetraspanin family Wyosine_form PF08608.12 PIK50912.1 - 1e-28 99.5 0.0 2.7e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 PIK50912.1 - 4.1e-19 69.6 0.0 1.3e-18 67.9 0.0 1.9 1 1 0 1 1 1 1 Radical SAM superfamily zf-BED PF02892.15 PIK50913.1 - 6.6e-10 38.8 0.5 1.4e-09 37.8 0.5 1.6 1 0 0 1 1 1 1 BED zinc finger DUF659 PF04937.15 PIK50913.1 - 9.8e-06 25.5 0.5 3.8e-05 23.6 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) DUF4413 PF14372.6 PIK50913.1 - 6.9e-05 23.1 0.7 0.00032 21.0 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4413) DUF3349 PF11829.8 PIK50913.1 - 0.33 11.8 3.3 0.62 10.9 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3349) KASH_CCD PF14662.6 PIK50914.1 - 0.0022 17.9 0.8 0.0037 17.1 0.8 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF4618 PF15397.6 PIK50914.1 - 0.017 14.6 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Med10 PF09748.9 PIK50914.1 - 0.03 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex RRP36 PF06102.12 PIK50914.1 - 0.24 11.3 3.9 3.2 7.7 0.9 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 zf-CCHC PF00098.23 PIK50914.1 - 0.26 11.4 1.1 0.51 10.5 1.1 1.4 1 0 0 1 1 1 0 Zinc knuckle Dimer_Tnp_hAT PF05699.14 PIK50917.1 - 0.049 13.4 0.1 0.091 12.6 0.1 1.5 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region G-patch PF01585.23 PIK50918.1 - 9.2e-10 38.3 2.0 1.8e-09 37.4 2.0 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK50918.1 - 0.042 13.9 1.8 0.11 12.6 1.8 1.8 1 0 0 1 1 1 0 G-patch domain rve PF00665.26 PIK50919.1 - 1.6e-16 60.6 0.0 5.9e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK50919.1 - 0.017 14.9 0.0 0.039 13.7 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain EMG1 PF03587.14 PIK50920.1 - 1.2e-68 230.6 0.0 1.4e-68 230.4 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase SNF5 PF04855.12 PIK50921.1 - 9.5e-58 195.8 0.6 5.8e-30 104.8 0.0 2.1 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 Pkinase PF00069.25 PIK50922.1 - 1.4e-05 24.6 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50922.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 PIK50923.1 - 2.6e-27 95.9 0.0 3.7e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK50923.1 - 4.8e-13 49.0 0.0 1e-12 47.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK50923.1 - 0.011 15.1 0.0 0.027 13.8 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Collagen PF01391.18 PIK50924.1 - 6.4e-17 61.1 65.6 2.6e-08 33.5 32.7 3.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) C1q PF00386.21 PIK50924.1 - 5.5e-14 52.5 0.2 1.2e-06 28.7 0.0 2.2 1 1 1 2 2 2 2 C1q domain LRR_6 PF13516.6 PIK50925.1 - 7.7e-32 106.6 19.1 5.9e-05 22.8 0.3 8.9 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 PIK50925.1 - 3.6e-10 39.0 0.1 20 6.2 0.0 7.8 8 0 0 8 8 8 0 Leucine Rich Repeat EF-hand_1 PF00036.32 PIK50925.1 - 5.6e-07 28.7 7.1 0.00083 18.7 0.6 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK50925.1 - 6.4e-06 26.5 3.2 1.7e-05 25.2 3.2 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK50925.1 - 8e-05 22.3 3.9 0.0033 17.2 0.3 2.9 2 0 0 2 2 2 1 EF-hand domain LRR_4 PF12799.7 PIK50925.1 - 0.00038 20.8 18.7 0.029 14.8 0.7 5.5 4 1 3 7 7 7 4 Leucine Rich repeats (2 copies) EF-hand_8 PF13833.6 PIK50925.1 - 0.00052 19.8 5.2 0.024 14.5 0.7 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK50925.1 - 0.0055 16.1 8.2 0.27 10.8 0.5 2.8 2 0 0 2 2 2 2 EF hand DAG_kinase_N PF14513.6 PIK50925.1 - 0.21 11.8 0.0 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus LRR_8 PF13855.6 PIK50925.1 - 1.1 9.1 24.0 0.18 11.6 3.9 5.9 4 2 1 6 6 6 0 Leucine rich repeat Peptidase_A17 PF05380.13 PIK50926.1 - 4.6e-49 166.5 0.0 8.3e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK50926.1 - 8.1e-06 25.5 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_4 PF13359.6 PIK50928.1 - 2.9e-29 101.8 0.0 4.1e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK50928.1 - 4.3e-12 46.1 0.0 8.3e-12 45.1 0.0 1.4 1 1 0 1 1 1 1 Plant transposon protein DP PF08781.10 PIK50929.1 - 0.026 14.4 0.8 0.048 13.5 0.8 1.4 1 0 0 1 1 1 0 Transcription factor DP PAS_3 PF08447.12 PIK50929.1 - 0.036 14.3 0.1 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 PAS fold MADF_DNA_bdg PF10545.9 PIK50930.1 - 6.1e-05 23.3 1.8 6.1e-05 23.3 1.8 2.6 3 1 0 3 3 3 1 Alcohol dehydrogenase transcription factor Myb/SANT-like V-set PF07686.17 PIK50931.1 - 1.3e-12 47.9 1.3 1.7e-07 31.4 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK50931.1 - 1.3e-11 44.9 4.7 0.00021 21.8 0.0 4.7 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK50931.1 - 1.6e-07 31.3 0.6 0.011 15.8 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK50931.1 - 8.1e-05 22.7 4.0 3.8 7.8 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.5 PIK50931.1 - 0.00084 19.4 0.0 0.0033 17.4 0.0 2.1 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 PIK50931.1 - 0.0011 19.3 4.5 2 8.8 0.1 4.5 4 1 0 4 4 4 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK50931.1 - 0.0057 16.4 1.1 2 8.2 0.1 3.1 2 1 0 2 2 2 2 Adenovirus E3 region protein CR1 C2-set_2 PF08205.12 PIK50931.1 - 0.027 14.5 0.0 0.09 12.9 0.0 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK50932.1 - 4.9e-08 33.1 1.4 1.7e-07 31.4 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK50932.1 - 1.2e-06 29.0 0.4 0.00013 22.5 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK50932.1 - 0.00086 19.3 0.0 0.0025 17.9 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain zf-CCHC PF00098.23 PIK50933.1 - 1.1e-06 28.5 16.2 0.00077 19.4 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK50933.1 - 0.00086 19.1 8.2 0.12 12.2 3.8 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK50933.1 - 0.026 14.4 0.2 0.026 14.4 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK50933.1 - 0.026 14.3 0.8 0.026 14.3 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK50933.1 - 0.05 13.4 11.1 5.7 6.7 0.4 3.5 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK50933.1 - 0.11 12.5 16.7 0.27 11.2 1.2 3.6 2 1 2 4 4 4 0 Zinc knuckle Cwf_Cwc_15 PF04889.12 PIK50934.1 - 0.0071 16.1 2.2 0.0072 16.1 2.2 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF4611 PF15387.6 PIK50934.1 - 0.021 15.0 1.7 0.021 15.0 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) GEN1_C PF18380.1 PIK50934.1 - 0.027 15.4 1.1 0.03 15.2 1.1 1.1 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain 14-3-3 PF00244.20 PIK50936.1 - 6.5e-86 287.4 2.8 7.6e-86 287.2 2.8 1.0 1 0 0 1 1 1 1 14-3-3 protein BCAS3 PF12490.8 PIK50937.1 - 4.1e-28 98.6 0.0 7.2e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 PIK50937.1 - 0.015 16.1 1.1 2.2 9.3 0.3 3.4 2 1 0 2 2 2 0 WD domain, G-beta repeat C2 PF00168.30 PIK50938.1 - 1.7e-22 79.6 0.2 2.1e-22 79.4 0.2 1.1 1 0 0 1 1 1 1 C2 domain AIG1 PF04548.16 PIK50940.1 - 3.1e-21 75.7 0.1 6e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK50940.1 - 7.6e-11 42.1 0.0 3e-10 40.2 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK50940.1 - 6e-05 23.0 0.8 0.00015 21.7 0.8 1.7 1 1 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK50940.1 - 0.0085 16.6 0.3 0.025 15.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter Dynamin_N PF00350.23 PIK50940.1 - 0.021 14.9 1.6 3.2 7.8 0.6 2.7 1 1 1 2 2 2 0 Dynamin family AAA_29 PF13555.6 PIK50940.1 - 0.094 12.5 0.2 0.34 10.7 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain FeoB_N PF02421.18 PIK50940.1 - 0.11 12.0 0.1 0.27 10.7 0.0 1.8 2 1 0 2 2 2 0 Ferrous iron transport protein B AIG1 PF04548.16 PIK50941.1 - 4e-07 29.6 0.2 7.2e-07 28.7 0.0 1.4 2 0 0 2 2 2 1 AIG1 family RVT_1 PF00078.27 PIK50942.1 - 2.9e-29 102.2 0.1 7.8e-29 100.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK50942.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Med18 protein AIG1 PF04548.16 PIK50943.1 - 3.7e-14 52.6 0.1 4.7e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK50943.1 - 4.2e-10 39.7 0.0 5.2e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK50943.1 - 3.9e-05 23.8 2.0 0.036 14.1 0.8 2.1 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 PIK50943.1 - 0.00011 22.1 0.8 0.00034 20.6 0.8 1.9 1 1 0 1 1 1 1 RsgA GTPase Septin PF00735.18 PIK50943.1 - 0.00091 18.6 0.0 0.001 18.4 0.0 1.1 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 PIK50943.1 - 0.0018 17.8 0.1 0.0024 17.4 0.1 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 PIK50943.1 - 0.011 15.1 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK50943.1 - 0.021 14.4 0.1 0.05 13.2 0.0 1.6 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 PIK50943.1 - 0.026 13.9 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 PIK50943.1 - 0.053 13.7 0.1 0.073 13.3 0.1 1.4 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 PIK50943.1 - 0.062 13.8 0.7 0.12 12.9 0.7 1.7 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 PIK50943.1 - 0.11 12.3 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.16 PIK50944.1 - 3.7e-08 33.0 0.2 6.5e-08 32.1 0.0 1.5 2 0 0 2 2 2 1 AIG1 family AIG1 PF04548.16 PIK50945.1 - 0.00015 21.1 0.5 0.00048 19.5 0.0 2.0 2 0 0 2 2 2 1 AIG1 family ATPase PF06745.13 PIK50945.1 - 0.0093 15.3 3.3 0.24 10.7 0.7 2.2 2 0 0 2 2 2 2 KaiC MMR_HSR1 PF01926.23 PIK50945.1 - 0.019 15.0 0.0 0.79 9.8 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase SYCE1 PF15233.6 PIK50945.1 - 0.025 14.7 1.1 0.05 13.7 1.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Dynamin_N PF00350.23 PIK50945.1 - 0.03 14.4 1.9 0.066 13.3 0.1 2.4 3 1 0 3 3 3 0 Dynamin family Hrs_helical PF12210.8 PIK50945.1 - 0.053 14.1 0.3 0.95 10.0 0.0 2.6 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate RsgA_GTPase PF03193.16 PIK50945.1 - 0.06 13.3 0.3 0.18 11.7 0.2 1.7 1 1 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 PIK50945.1 - 0.061 13.8 1.8 0.94 10.0 0.0 2.9 2 1 0 2 2 2 0 ABC transporter Importin_rep PF18773.1 PIK50945.1 - 0.063 13.0 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Importin 13 repeat SLAIN PF15301.6 PIK50945.1 - 0.072 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 SLAIN motif-containing family DASH_Dam1 PF08653.10 PIK50945.1 - 0.17 11.7 0.7 6.9 6.5 0.1 3.0 3 0 0 3 3 3 0 DASH complex subunit Dam1 bZIP_1 PF00170.21 PIK50945.1 - 1.1 9.5 4.4 2.5 8.3 0.1 3.3 2 1 1 3 3 3 0 bZIP transcription factor 7tm_2 PF00002.24 PIK50946.1 - 7.2e-08 32.0 13.1 1.5e-07 31.0 13.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) MTABC_N PF16185.5 PIK50946.1 - 0.012 15.1 1.7 0.012 15.1 1.7 2.0 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DUF1980 PF09323.10 PIK50946.1 - 0.13 12.1 0.6 0.43 10.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) TMEM107 PF14995.6 PIK50946.1 - 1.1 9.7 11.3 0.93 9.9 3.0 3.1 2 2 0 2 2 2 0 Transmembrane protein DUF373 PF04123.13 PIK50946.1 - 2.5 7.5 5.6 4.2 6.7 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF373) 7tm_2 PF00002.24 PIK50947.1 - 2.6e-08 33.5 6.3 3.3e-08 33.1 6.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) ASTN_2_hairpin PF18577.1 PIK50947.1 - 0.096 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Astrotactin-2 C-terminal beta-hairpin domain DUF996 PF06195.13 PIK50947.1 - 3.6 7.9 10.1 0.31 11.3 2.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF996) Somatomedin_B PF01033.17 PIK50948.1 - 2.5e-08 34.2 13.1 1.2e-07 32.0 13.1 2.3 1 0 0 1 1 1 1 Somatomedin B domain NACHT PF05729.12 PIK50949.1 - 9.3e-09 35.4 0.0 2.4e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK50949.1 - 4.6e-06 27.0 0.1 0.00018 21.8 0.0 3.3 3 1 1 4 4 4 1 AAA domain AAA_16 PF13191.6 PIK50949.1 - 7.6e-06 26.4 0.1 5e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain TPR_12 PF13424.6 PIK50949.1 - 2.4e-05 24.6 1.7 0.55 10.6 0.2 4.3 3 2 2 5 5 5 3 Tetratricopeptide repeat UPF0147 PF03685.13 PIK50949.1 - 0.014 15.5 0.3 0.041 13.9 0.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) AAA_19 PF13245.6 PIK50949.1 - 0.014 15.7 0.0 0.082 13.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Utp12 PF04003.12 PIK50949.1 - 0.037 14.3 0.1 2.4 8.5 0.0 3.3 3 1 1 4 4 4 0 Dip2/Utp12 Family DndB PF14072.6 PIK50949.1 - 0.073 12.3 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 DNA-sulfur modification-associated AAA_30 PF13604.6 PIK50949.1 - 0.076 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 PIK50949.1 - 0.087 12.8 0.1 2.1 8.4 0.1 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA PF00004.29 PIK50949.1 - 0.14 12.6 0.0 0.75 10.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF4062 PF13271.6 PIK50950.1 - 3.9e-08 33.5 0.0 1.1e-07 32.1 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) MTES_1575 PF18741.1 PIK50950.1 - 0.022 14.9 0.5 0.048 13.8 0.2 1.8 2 0 0 2 2 2 0 REase_MTES_1575 RVT_1 PF00078.27 PIK50952.1 - 4.3e-26 91.8 0.0 1.3e-25 90.3 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_Tnp_Tc3_2 PF01498.18 PIK50953.1 - 1.5e-09 37.9 0.9 3.5e-09 36.8 0.9 1.6 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 PIK50953.1 - 3.9e-05 24.2 2.2 0.00029 21.4 0.3 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_31 PF13560.6 PIK50953.1 - 0.0028 18.0 1.5 0.0094 16.3 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 PIK50953.1 - 0.027 14.5 1.6 0.069 13.2 0.1 2.2 3 0 0 3 3 3 0 Helix-turn-helix TrmB PF01978.19 PIK50953.1 - 0.035 14.0 0.1 0.072 13.0 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 PIK50953.1 - 0.041 13.7 3.1 2.7 7.9 0.1 3.2 3 1 0 3 3 3 0 Homeodomain-like domain Arm-DNA-bind_3 PF13356.6 PIK50953.1 - 0.095 13.1 1.4 0.21 12.0 0.6 1.9 2 0 0 2 2 2 0 Arm DNA-binding domain HTH_7 PF02796.15 PIK50953.1 - 0.099 12.7 0.7 2.5 8.2 0.1 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_25 PF13413.6 PIK50953.1 - 0.21 11.5 1.4 0.35 10.8 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_19 PF12844.7 PIK50953.1 - 0.25 11.4 1.4 1.1 9.3 0.2 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain zf-B_box PF00643.24 PIK50954.1 - 6.5e-16 58.2 35.0 1.7e-08 34.4 11.3 2.8 2 1 0 2 2 2 2 B-box zinc finger RasGAP_C PF03836.15 PIK50954.1 - 0.026 14.6 1.6 0.067 13.3 0.8 2.0 1 1 1 2 2 2 0 RasGAP C-terminus IBR PF01485.21 PIK50954.1 - 1.2 9.4 28.2 2.3 8.5 9.5 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 PIK50955.1 - 1.2e-30 106.6 0.5 2.2e-30 105.8 0.1 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4940 PF16298.5 PIK50955.1 - 0.072 12.7 0.3 0.23 11.1 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4940) Syndecan PF01034.20 PIK50956.1 - 0.22 11.5 0.2 0.39 10.7 0.2 1.4 1 0 0 1 1 1 0 Syndecan domain SRCR PF00530.18 PIK50957.1 - 1.3e-109 359.4 19.5 9.8e-28 96.6 1.3 4.0 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK50957.1 - 2.7e-25 88.8 19.6 3.7e-06 27.4 1.3 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK50957.1 - 9e-13 48.7 0.0 0.082 13.4 0.0 4.6 4 1 0 4 4 4 4 Hepsin, SRCR domain YecR PF13992.6 PIK50957.1 - 3.9e-05 23.9 9.2 4.4 7.7 0.2 4.9 4 1 0 4 4 4 3 YecR-like lipoprotein Fibrinogen_C PF00147.18 PIK50958.1 - 2.5e-18 66.7 1.2 2.6e-18 66.6 1.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FAM217 PF15344.6 PIK50960.1 - 0.04 13.9 2.8 0.039 13.9 2.8 1.0 1 0 0 1 1 1 0 FAM217 family Cnd3 PF12719.7 PIK50961.1 - 2.3e-83 279.8 7.2 2.3e-83 279.8 7.2 3.9 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 PIK50961.1 - 1.2e-16 60.8 2.8 0.00019 21.7 0.1 5.2 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.22 PIK50961.1 - 1.7e-08 34.0 7.5 0.052 13.8 0.1 7.4 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 PIK50961.1 - 5.7e-07 29.7 12.6 0.017 15.2 0.1 5.2 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK50961.1 - 1.7e-05 25.2 0.5 0.23 12.0 0.1 5.1 5 0 0 5 5 5 1 HEAT-like repeat UVR PF02151.19 PIK50961.1 - 0.0009 18.9 9.9 0.0012 18.5 3.9 3.3 2 0 0 2 2 2 1 UvrB/uvrC motif Vac14_Fab1_bd PF12755.7 PIK50961.1 - 0.042 14.4 1.6 14 6.3 0.0 3.7 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region DUF2353 PF09789.9 PIK50962.1 - 7.1e-06 25.6 27.8 0.00063 19.2 1.5 3.1 1 1 2 3 3 3 2 Uncharacterized coiled-coil protein (DUF2353) Cep57_CLD_2 PF14197.6 PIK50962.1 - 0.0018 18.3 15.9 0.09 12.9 0.5 4.0 3 0 0 3 3 3 2 Centrosome localisation domain of PPC89 SPATA1_C PF15743.5 PIK50962.1 - 0.02 14.9 4.4 0.02 14.9 4.4 3.9 4 1 1 5 5 5 0 Spermatogenesis-associated C-terminus FliD_C PF07195.12 PIK50962.1 - 2 7.8 7.4 2.4 7.5 0.1 2.6 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus CMD PF02627.20 PIK50964.1 - 6.9e-13 48.5 0.1 2.7e-12 46.6 0.0 1.9 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family PA26 PF04636.13 PIK50964.1 - 0.0098 14.9 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) HEAT_2 PF13646.6 PIK50965.1 - 1.7e-20 73.2 4.1 2.8e-08 34.1 0.1 5.2 3 1 2 5 5 5 4 HEAT repeats HEAT PF02985.22 PIK50965.1 - 7.6e-11 41.3 11.7 0.51 10.7 0.0 8.5 9 0 0 9 9 9 4 HEAT repeat Cnd1 PF12717.7 PIK50965.1 - 7e-06 26.2 3.6 0.72 9.9 0.0 4.6 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK50965.1 - 0.00021 21.7 6.3 26 5.4 0.0 6.2 6 2 0 6 6 6 0 HEAT-like repeat TSGP1 PF07771.11 PIK50965.1 - 0.027 14.6 1.6 0.054 13.7 1.6 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 RICTOR_V PF14668.6 PIK50965.1 - 0.039 14.2 0.0 1.9 8.8 0.0 3.1 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 PIK50965.1 - 0.11 11.1 0.8 1.9 6.9 0.0 2.8 3 2 1 4 4 4 0 Adaptin N terminal region PRANC PF09372.10 PIK50965.1 - 0.81 10.1 2.6 1.1 9.7 0.2 2.3 2 0 0 2 2 2 0 PRANC domain Ribosomal_L35p PF01632.19 PIK50966.1 - 9.7e-11 42.0 2.7 1.8e-10 41.2 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L35 Macoilin PF09726.9 PIK50967.1 - 8.9e-244 811.1 12.3 1.1e-243 810.7 12.3 1.1 1 0 0 1 1 1 1 Macoilin family Malic_M PF03949.15 PIK50967.1 - 0.082 12.2 0.9 0.15 11.3 0.9 1.3 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain GLE1 PF07817.13 PIK50967.1 - 1.3 8.2 11.9 0.4 9.8 0.1 2.6 2 1 0 2 2 2 0 GLE1-like protein DUF2935 PF11155.8 PIK50967.1 - 2.3 8.5 10.0 4.6 7.6 5.7 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) HALZ PF02183.18 PIK50967.1 - 5.3 7.4 12.7 0.33 11.2 1.1 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper ANF_receptor PF01094.28 PIK50969.1 - 4.3e-58 197.1 0.0 5.3e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK50969.1 - 7.9e-06 25.8 0.0 1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein 7tm_3 PF00003.22 PIK50970.1 - 2.9e-43 148.3 18.3 4e-43 147.8 18.3 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 PIK50970.1 - 5.6e-11 42.2 11.6 1e-10 41.4 11.6 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR TMEM174 PF15029.6 PIK50970.1 - 0.056 13.2 1.7 0.27 10.9 2.6 1.7 2 0 0 2 2 2 0 Transmembrane protein 174 WTF PF03303.13 PIK50971.1 - 0.048 13.4 2.0 1.2 8.8 0.9 2.1 1 1 1 2 2 2 0 WTF protein Peptidase_U4 PF03419.13 PIK50971.1 - 0.26 10.5 7.5 0.37 10.1 7.5 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA DUF1700 PF08006.11 PIK50971.1 - 0.41 10.2 4.0 0.65 9.5 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) MNHE PF01899.16 PIK50971.1 - 0.49 10.2 4.0 0.51 10.1 3.1 1.5 1 1 0 1 1 1 0 Na+/H+ ion antiporter subunit PDR_CDR PF06422.12 PIK50971.1 - 0.88 9.5 0.0 0.88 9.5 0.0 2.8 2 1 1 3 3 3 0 CDR ABC transporter MARVEL PF01284.23 PIK50972.1 - 7.3e-06 26.1 14.3 1.9e-05 24.7 13.9 1.7 1 1 1 2 2 2 2 Membrane-associating domain DUF2417 PF10329.9 PIK50972.1 - 0.051 13.0 8.3 0.052 12.9 8.3 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) MutS_II PF05188.17 PIK50973.1 - 8.6e-19 68.2 0.0 1.6e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 PIK50973.1 - 1.6e-15 57.3 0.2 5.1e-15 55.7 0.1 1.8 2 0 0 2 2 2 1 MutS domain I MutS_V PF00488.21 PIK50974.1 - 8.9e-82 273.7 0.1 1.9e-81 272.6 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 PIK50974.1 - 7.2e-09 35.9 0.1 1.8e-08 34.6 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_III PF05192.18 PIK50974.1 - 0.00041 20.6 0.6 0.00076 19.8 0.6 1.4 1 0 0 1 1 1 1 MutS domain III AAA_27 PF13514.6 PIK50974.1 - 0.0009 18.9 0.0 0.0024 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain CCDC73 PF15818.5 PIK50974.1 - 0.14 9.9 1.5 0.21 9.4 1.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family AAA_23 PF13476.6 PIK50974.1 - 0.3 11.6 2.3 2 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain RT_RNaseH_2 PF17919.1 PIK50975.1 - 1.9e-29 101.6 0.0 6.2e-29 100.0 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK50975.1 - 3.9e-26 92.0 0.1 6.1e-26 91.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK50975.1 - 1.1e-19 70.7 0.0 2.8e-19 69.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK50976.1 - 6e-22 77.5 1.3 8.4e-22 77.0 1.3 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK50976.1 - 1.2e-05 25.5 0.4 2.1e-05 24.6 0.4 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DSPc PF00782.20 PIK50977.1 - 2.1e-27 95.5 0.0 2.4e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK50977.1 - 0.00015 21.4 0.0 0.00016 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK50977.1 - 0.0012 19.0 0.0 0.0013 18.9 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate rve PF00665.26 PIK50979.1 - 2.6e-23 82.4 0.0 6.6e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK50979.1 - 3.1e-19 68.9 0.0 7.9e-19 67.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK50979.1 - 9.3e-18 64.1 1.0 9.3e-18 64.1 1.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK50979.1 - 9.7e-11 41.9 0.0 3e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK50979.1 - 0.003 17.7 0.6 0.003 17.7 0.6 2.8 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 PIK50979.1 - 0.013 15.3 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain DUF2284 PF10050.9 PIK50979.1 - 0.022 14.5 0.3 2.9 7.6 0.1 2.3 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) MycE_N PF17843.1 PIK50979.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RVT_1 PF00078.27 PIK50980.1 - 7.1e-11 42.0 0.0 8.9e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease PF09668.10 PIK50981.1 - 0.074 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK50982.1 - 1.4e-07 31.3 1.9 1.4e-07 31.3 1.9 1.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK50982.1 - 0.00019 21.2 1.9 0.00021 21.1 0.1 2.0 2 0 0 2 2 2 1 Zinc knuckle PNMA PF14893.6 PIK50982.1 - 0.009 15.4 1.8 0.017 14.5 0.2 1.8 1 1 1 2 2 2 1 PNMA T4_baseplate PF12322.8 PIK50982.1 - 0.054 13.0 0.3 0.094 12.2 0.3 1.4 1 0 0 1 1 1 0 T4 bacteriophage base plate protein zf-C2H2_10 PF16588.5 PIK50982.1 - 0.076 12.8 0.4 0.12 12.1 0.4 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK50982.1 - 0.086 12.9 0.3 0.27 11.3 0.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK50982.1 - 0.12 12.1 0.4 0.27 11.0 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-RING_11 PF17123.5 PIK50983.1 - 1.1e-05 25.1 2.3 1.1e-05 25.1 2.3 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 PIK50983.1 - 0.00034 20.9 1.2 0.00034 20.9 1.2 3.8 4 0 0 4 4 4 1 Ring finger domain LamB_YcsF PF03746.16 PIK50985.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 LamB/YcsF family FHA PF00498.26 PIK50986.1 - 2e-12 47.3 0.1 3.4e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK50986.1 - 3.1e-09 37.0 0.0 4.7e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RVT_1 PF00078.27 PIK50987.1 - 3.5e-06 26.7 0.0 4.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NPR1_like_C PF12313.8 PIK50987.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal Symplekin_C PF12295.8 PIK50988.1 - 3.5e-69 232.6 4.5 3.5e-69 232.6 4.5 2.5 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 PIK50988.1 - 1.2e-28 100.3 2.9 1.3e-27 96.9 0.4 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3453) Dpy-30 PF05186.13 PIK50989.1 - 1.1e-20 73.1 1.1 2.1e-20 72.2 1.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif GDA1_CD39 PF01150.17 PIK50990.1 - 1.7e-75 254.3 0.0 4e-67 226.7 0.0 2.1 1 1 1 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 PIK50990.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family SAP PF02037.27 PIK50991.1 - 1.4e-11 43.9 0.2 3.3e-11 42.7 0.2 1.7 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 PIK50991.1 - 0.0063 16.2 0.0 0.02 14.6 0.0 1.9 1 0 0 1 1 1 1 HeH/LEM domain Porin_5 PF16930.5 PIK50991.1 - 0.26 9.7 21.0 0.52 8.7 21.0 1.4 1 0 0 1 1 1 0 Putative porin AAA_33 PF13671.6 PIK50992.1 - 3.2e-29 101.9 0.0 7.1e-29 100.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK50992.1 - 5.5e-07 30.2 0.1 1.3e-06 28.9 0.1 1.7 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 PIK50992.1 - 7.9e-05 22.0 0.0 0.00021 20.6 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 PIK50992.1 - 7.9e-05 23.1 0.2 0.00017 22.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 PIK50992.1 - 0.0036 17.7 0.1 0.044 14.2 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 PIK50992.1 - 0.0043 16.5 0.9 0.099 12.0 0.0 2.6 3 0 0 3 3 3 1 Bacterial TniB protein Roc PF08477.13 PIK50992.1 - 0.0079 16.4 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase KTI12 PF08433.10 PIK50992.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_22 PF13401.6 PIK50992.1 - 0.017 15.4 0.0 0.038 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 PIK50992.1 - 0.037 13.2 0.0 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 PIK50992.1 - 0.046 13.7 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 PIK50992.1 - 0.047 13.7 0.1 0.31 11.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK50992.1 - 0.048 13.2 0.5 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 PIK50992.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 PIK50992.1 - 0.12 12.3 0.1 0.3 11.0 0.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 PIK50992.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Troponin PF00992.20 PIK50993.1 - 3.7e-06 27.3 0.1 3.7e-06 27.3 0.1 2.5 2 1 0 2 2 2 1 Troponin Clathrin_lg_ch PF01086.17 PIK50993.1 - 0.098 12.7 27.5 0.17 11.9 27.5 1.4 1 0 0 1 1 1 0 Clathrin light chain Caldesmon PF02029.15 PIK50993.1 - 1.1 8.0 40.9 0.11 11.2 36.5 1.5 1 1 0 1 1 1 0 Caldesmon DDHD PF02862.17 PIK50993.1 - 2.4 8.3 8.2 3.3 7.8 8.2 1.3 1 0 0 1 1 1 0 DDHD domain Stathmin PF00836.19 PIK50993.1 - 5.2 7.0 32.1 0.24 11.4 25.3 2.2 2 1 0 2 2 2 0 Stathmin family CDC45 PF02724.14 PIK50993.1 - 6.9 4.8 16.1 7.4 4.7 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Fibrinogen_C PF00147.18 PIK50994.1 - 7.2e-24 84.8 2.4 7.8e-24 84.7 2.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK50994.1 - 0.019 14.8 1.2 0.033 14.0 1.2 1.4 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) 2-oxoacid_dh PF00198.23 PIK50995.1 - 1.3e-71 240.7 0.0 1.8e-71 240.3 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 PIK50995.1 - 5.2e-20 71.1 0.3 1.2e-19 69.9 0.1 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 PIK50995.1 - 4.5e-05 23.7 0.4 0.00015 22.1 0.1 2.0 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 PIK50995.1 - 0.0056 16.5 0.0 0.054 13.3 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-gua_Ptrans PF00217.19 PIK50995.1 - 0.042 13.3 0.3 0.47 9.9 0.0 2.1 1 1 1 2 2 2 0 ATP:guanido phosphotransferase, C-terminal catalytic domain DUF3614 PF12267.8 PIK50995.1 - 0.23 11.9 1.0 6.7 7.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3614) EGF_CA PF07645.15 PIK50998.1 - 4e-21 74.9 58.9 3.3e-09 36.8 11.9 4.8 3 1 1 4 4 4 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK50998.1 - 7.7e-18 64.5 64.4 1.2e-08 35.1 10.4 4.7 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK50998.1 - 6.5e-08 32.7 48.8 0.0037 17.5 4.3 5.3 4 2 0 4 4 4 4 EGF-like domain EGF_MSP1_1 PF12946.7 PIK50998.1 - 1.7e-07 31.2 40.5 0.00014 21.8 5.4 4.7 4 0 0 4 4 4 3 MSP1 EGF domain 1 EGF_3 PF12947.7 PIK50998.1 - 1.8e-06 28.0 53.8 0.00013 22.1 8.5 4.8 3 1 1 4 4 4 3 EGF domain Plasmod_Pvs28 PF06247.11 PIK50998.1 - 3.9e-05 23.9 5.8 3.9e-05 23.9 5.8 4.5 4 0 0 4 4 4 3 Pvs28 EGF domain MCU PF04678.13 PIK50999.1 - 4.9e-63 212.4 1.6 5.8e-63 212.2 1.6 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter AAA_23 PF13476.6 PIK50999.1 - 0.66 10.4 3.7 1.2 9.7 3.7 1.4 1 1 0 1 1 1 0 AAA domain PAZ PF02170.22 PIK51000.1 - 5.5e-33 113.7 1.1 9.4e-33 112.9 1.1 1.4 1 0 0 1 1 1 1 PAZ domain Piwi PF02171.17 PIK51000.1 - 6.9e-31 107.6 0.2 1.3e-30 106.7 0.0 1.5 2 0 0 2 2 2 1 Piwi domain ArgoL1 PF08699.10 PIK51000.1 - 6.6e-06 25.7 0.0 5.6e-05 22.7 0.0 2.5 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoN PF16486.5 PIK51000.1 - 0.0044 17.6 0.7 0.0082 16.8 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of argonaute PCNA_C PF02747.15 PIK51001.1 - 1.8e-53 180.1 0.0 2.8e-52 176.3 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 PIK51001.1 - 6.2e-47 158.5 1.7 1.2e-46 157.5 1.7 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 PIK51001.1 - 3.9e-06 26.5 0.1 5e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 PIK51001.1 - 5.6e-05 22.3 1.1 0.00039 19.6 0.3 2.1 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 UPF0561 PF10573.9 PIK51002.1 - 3.1e-15 56.3 1.0 3.8e-15 56.1 1.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0561 EGF_CA PF07645.15 PIK51003.1 - 0.043 14.0 9.7 0.086 13.1 9.7 1.5 1 0 0 1 1 1 0 Calcium-binding EGF domain Herpes_gE PF02480.16 PIK51003.1 - 0.057 12.2 0.0 0.087 11.6 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E EGF PF00008.27 PIK51003.1 - 0.12 12.7 6.2 0.47 10.8 6.2 2.0 1 0 0 1 1 1 0 EGF-like domain TIL PF01826.17 PIK51003.1 - 0.16 12.3 6.1 0.31 11.3 6.1 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain PARM PF17061.5 PIK51003.1 - 4.6 7.3 11.3 11 6.1 6.7 2.0 1 1 1 2 2 2 0 PARM DHHC PF01529.20 PIK51004.1 - 5.9e-31 107.3 12.4 1.1e-30 106.5 12.4 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase SH3_2 PF07653.17 PIK51004.1 - 0.016 14.9 0.0 0.041 13.6 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain RTX_C PF08339.10 PIK51004.1 - 0.11 12.6 0.3 0.17 11.9 0.3 1.3 1 0 0 1 1 1 0 RTX C-terminal domain Tissue_fac PF01108.17 PIK51004.1 - 1.7 8.5 6.9 3.2 7.6 0.1 2.7 2 1 0 2 2 2 0 Tissue factor CcmD PF04995.14 PIK51005.1 - 9.3 6.4 8.0 3.9 7.6 4.0 2.5 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) EGF PF00008.27 PIK51006.1 - 0.0022 18.3 4.4 0.0043 17.3 4.4 1.6 1 0 0 1 1 1 1 EGF-like domain TPK_catalytic PF04263.16 PIK51006.1 - 0.0074 16.3 0.2 0.016 15.3 0.2 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain DUF4834 PF16118.5 PIK51006.1 - 0.0079 17.1 0.1 0.017 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF2970 PF11174.8 PIK51006.1 - 0.014 15.3 0.4 0.027 14.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) EGF_2 PF07974.13 PIK51006.1 - 0.016 15.6 8.2 0.043 14.2 8.2 1.8 1 0 0 1 1 1 0 EGF-like domain Zip PF02535.22 PIK51006.1 - 0.068 12.4 0.1 0.076 12.2 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter hEGF PF12661.7 PIK51006.1 - 0.41 11.3 3.8 1.8 9.3 3.8 2.2 1 1 0 1 1 1 0 Human growth factor-like EGF DUF1533 PF07550.11 PIK51007.1 - 0.0012 18.7 0.2 11 6.0 0.0 4.2 2 1 1 3 3 3 2 Protein of unknown function (DUF1533) DUF4738 PF15889.5 PIK51007.1 - 0.002 18.0 12.5 35 4.2 0.1 7.4 2 2 7 9 9 9 4 Domain of unknown function (DUF4738) Activin_recp PF01064.23 PIK51008.1 - 0.013 16.6 0.4 0.014 16.5 0.4 1.1 1 0 0 1 1 1 0 Activin types I and II receptor domain Pkinase_Tyr PF07714.17 PIK51009.1 - 4.6e-34 117.9 0.0 6.6e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51009.1 - 6.2e-31 107.7 0.0 9.8e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 PIK51009.1 - 1.7e-14 52.9 0.6 4.5e-14 51.6 0.6 1.8 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif FTA2 PF13095.6 PIK51009.1 - 0.0027 17.4 0.0 0.0075 15.9 0.0 1.7 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 PIK51009.1 - 0.012 14.5 0.1 0.028 13.2 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 PIK51009.1 - 0.11 11.4 0.0 0.46 9.4 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain CTNNB1_binding PF08347.11 PIK51010.1 - 6.2e-27 95.1 1.1 6.2e-27 95.1 1.1 3.6 3 1 0 3 3 3 1 N-terminal CTNNB1 binding HMG_box PF00505.19 PIK51010.1 - 1.2e-21 76.9 1.0 2.6e-21 75.8 1.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK51010.1 - 9.1e-08 32.6 1.0 9.1e-08 32.6 1.0 1.8 2 0 0 2 2 2 1 HMG-box domain RNase_H2_suC PF08615.11 PIK51010.1 - 0.086 13.0 1.1 0.52 10.5 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Trypsin PF00089.26 PIK51011.1 - 1.4e-24 87.1 0.0 2.4e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.15 PIK51011.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 PIK51011.1 - 0.15 13.0 0.0 0.34 11.8 0.0 1.6 2 0 0 2 2 2 0 Trypsin-like peptidase domain DUF1986 PF09342.11 PIK51011.1 - 0.18 12.2 0.0 0.39 11.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Trypsin PF00089.26 PIK51012.1 - 6.3e-56 189.7 0.0 7.2e-56 189.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK51012.1 - 5.7e-05 24.0 0.0 8.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 PIK51012.1 - 0.0059 16.2 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 1 Chymotrypsin family Peptidase-S1 DUF1986 PF09342.11 PIK51012.1 - 0.068 13.6 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Trypsin PF00089.26 PIK51013.1 - 3.9e-11 43.2 0.3 5.4e-11 42.7 0.3 1.2 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 PIK51014.1 - 1.8e-25 90.1 0.0 2.1e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Ribosomal_S11 PF00411.19 PIK51015.1 - 3.5e-46 156.1 0.9 4.5e-46 155.8 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 PIK51015.1 - 0.096 12.9 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) BKACE PF05853.12 PIK51015.1 - 0.098 12.0 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme SWIM PF04434.17 PIK51016.1 - 0.0077 15.9 6.8 0.015 15.0 6.8 1.4 1 0 0 1 1 1 1 SWIM zinc finger SUIM_assoc PF16619.5 PIK51018.1 - 0.16 12.0 7.9 1.3 9.2 1.8 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Chlamy_scaf PF09675.10 PIK51019.1 - 0.11 12.9 0.1 1.3 9.4 0.1 2.2 2 0 0 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) RPE65 PF03055.15 PIK51020.1 - 7.2e-92 309.0 0.2 1.8e-49 169.2 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein Ank_2 PF12796.7 PIK51021.1 - 1.5e-67 224.1 16.7 1.3e-16 60.9 1.9 5.1 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK51021.1 - 1e-66 220.5 22.4 9.9e-14 51.5 0.0 8.1 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 PIK51021.1 - 1.2e-59 196.3 28.0 1.4e-07 31.6 0.0 10.5 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 PIK51021.1 - 6.8e-54 173.5 11.6 3.5e-06 27.0 0.0 11.1 11 0 0 11 11 11 11 Ankyrin repeat Ank_5 PF13857.6 PIK51021.1 - 1.8e-50 168.3 15.0 9.5e-11 41.7 0.0 8.7 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Imm_superinfect PF14373.6 PIK51021.1 - 0.18 11.7 1.1 16 5.5 0.0 3.8 5 0 0 5 5 5 0 Superinfection immunity protein Ank_2 PF12796.7 PIK51022.1 - 3.4e-62 207.0 14.6 1.4e-17 64.0 1.5 5.9 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK51022.1 - 1.7e-56 187.9 19.0 1.7e-10 41.2 0.3 7.5 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 PIK51022.1 - 1.8e-56 186.3 30.0 2.5e-06 27.7 0.1 11.5 11 0 0 11 11 11 10 Ankyrin repeat UPA_2 PF17809.1 PIK51022.1 - 7.3e-51 171.4 0.2 1.4e-50 170.5 0.2 1.5 1 0 0 1 1 1 1 UPA domain Ank_3 PF13606.6 PIK51022.1 - 1.3e-50 163.4 14.0 1.7e-05 24.8 0.0 11.0 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 PIK51022.1 - 1.5e-50 168.6 21.6 4.4e-10 39.6 0.0 9.4 2 1 8 10 10 10 10 Ankyrin repeats (many copies) ZU5 PF00791.20 PIK51022.1 - 2e-34 117.8 2.0 2.1e-25 88.9 0.0 2.9 3 0 0 3 3 3 2 ZU5 domain Death PF00531.22 PIK51022.1 - 5.4e-18 64.9 0.1 1.4e-17 63.6 0.1 1.7 1 0 0 1 1 1 1 Death domain wnt PF00110.19 PIK51023.1 - 5.2e-53 180.6 1.3 5.8e-53 180.5 1.3 1.0 1 0 0 1 1 1 1 wnt family wnt PF00110.19 PIK51024.1 - 1.5e-75 254.6 30.6 2.5e-75 253.9 30.6 1.3 1 1 0 1 1 1 1 wnt family Cadherin PF00028.17 PIK51025.1 - 5.2e-134 437.1 55.5 6.2e-18 65.0 0.1 12.1 12 0 0 12 12 12 11 Cadherin domain Cadherin_3 PF16184.5 PIK51025.1 - 2.4e-13 50.1 42.6 0.00098 19.1 0.3 11.2 11 0 0 11 11 11 7 Cadherin-like Cadherin_2 PF08266.12 PIK51025.1 - 2.5e-12 46.5 0.3 0.0013 18.5 0.1 7.0 7 0 0 7 7 7 3 Cadherin-like Cadherin_pro PF08758.11 PIK51025.1 - 3.5e-07 30.3 0.9 0.28 11.4 0.0 5.2 5 0 0 5 5 5 2 Cadherin prodomain like 7tm_3 PF00003.22 PIK51026.1 - 4.4e-10 39.7 18.8 5.2e-10 39.5 18.8 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF3040 PF11239.8 PIK51026.1 - 0.066 13.5 2.1 0.14 12.4 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) ANF_receptor PF01094.28 PIK51027.1 - 3.5e-86 289.5 0.1 8.1e-56 189.6 0.0 2.6 2 1 0 2 2 2 2 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK51027.1 - 1.6e-07 31.4 3.2 7.9e-07 29.0 0.8 2.9 2 1 0 2 2 2 1 Periplasmic binding protein ANF_receptor PF01094.28 PIK51028.1 - 2.4e-14 53.2 0.0 2.7e-14 53.0 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region DnaA_N PF11638.8 PIK51028.1 - 0.045 13.5 0.0 0.31 10.8 0.0 2.4 2 0 0 2 2 2 0 DnaA N-terminal domain SRCR PF00530.18 PIK51029.1 - 6.2e-28 97.2 0.4 1.5e-27 96.0 0.4 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Zona_pellucida PF00100.23 PIK51029.1 - 1.5e-23 83.9 0.6 2.2e-23 83.4 0.6 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain SRCR_2 PF15494.6 PIK51029.1 - 3.5e-05 24.3 0.2 8.1e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK51030.1 - 2.9e-63 210.6 6.6 2.8e-33 114.4 0.6 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK51030.1 - 7.6e-10 39.2 8.9 3.6e-05 24.2 0.2 3.2 3 1 0 3 3 3 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK51030.1 - 3e-05 24.5 0.1 0.11 13.0 0.0 2.7 2 0 0 2 2 2 2 Hepsin, SRCR domain YecR PF13992.6 PIK51030.1 - 0.0011 19.2 1.1 0.7 10.2 0.2 3.3 2 1 0 2 2 2 2 YecR-like lipoprotein IKBKB_SDD PF18397.1 PIK51031.1 - 4.5e-36 124.6 6.3 6.2e-36 124.1 6.3 1.1 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain SIX1_SD PF16878.5 PIK51031.1 - 0.21 12.1 2.0 0.58 10.7 2.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator, SIX1, N-terminal SD domain TBK1_ULD PF18396.1 PIK51032.1 - 0.014 15.3 0.1 0.021 14.8 0.1 1.2 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain ubiquitin PF00240.23 PIK51032.1 - 0.014 15.1 0.2 0.036 13.8 0.1 1.7 1 1 0 1 1 1 0 Ubiquitin family Ubiquitin_2 PF14560.6 PIK51032.1 - 0.021 15.3 0.1 0.033 14.6 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Pkinase PF00069.25 PIK51033.1 - 1.5e-54 185.2 0.0 1.9e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51033.1 - 7.3e-38 130.3 0.0 9.3e-38 130.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK51033.1 - 9.3e-05 21.4 0.0 0.00014 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK51033.1 - 0.0003 20.2 0.0 0.0008 18.8 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 PIK51033.1 - 0.0038 16.8 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 PIK51033.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family bcl-2I13 PF12201.8 PIK51033.1 - 0.18 11.7 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 Bcl2-interacting killer, BH3-domain containing UreD PF01774.17 PIK51034.1 - 9.7e-30 104.1 0.2 1.9e-16 60.7 0.0 2.1 2 0 0 2 2 2 2 UreD urease accessory protein 7tm_1 PF00001.21 PIK51035.1 - 1.4e-44 152.4 11.0 1.6e-44 152.2 11.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK51035.1 - 3.2e-07 30.0 7.3 4.1e-07 29.6 7.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK51035.1 - 3.6e-07 30.1 16.8 4.9e-07 29.6 16.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK51035.1 - 0.00012 21.9 9.9 0.00019 21.2 9.9 1.3 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srw PF10324.9 PIK51035.1 - 0.016 14.5 13.1 0.026 13.8 13.1 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw zf-CCHC PF00098.23 PIK51036.1 - 9.1e-08 31.8 14.7 0.00039 20.4 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK51036.1 - 0.0014 18.4 11.1 0.64 9.8 0.3 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK51036.1 - 0.01 15.6 0.7 0.01 15.6 0.7 2.7 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 PIK51036.1 - 0.013 15.3 0.2 0.013 15.3 0.2 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK51036.1 - 0.032 14.1 14.0 0.18 11.7 4.3 3.1 3 1 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK51036.1 - 0.38 10.8 16.1 0.88 9.6 0.3 3.7 2 1 2 4 4 4 0 Zinc knuckle GPS PF01825.21 PIK51037.1 - 5.3e-06 26.9 0.3 1.3e-05 25.6 0.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif VWA PF00092.28 PIK51037.1 - 0.025 14.9 0.8 0.078 13.2 0.8 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain DUF4035 PF13227.6 PIK51037.1 - 0.065 13.0 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4035) DUF1400 PF07176.11 PIK51037.1 - 0.09 13.1 0.4 0.27 11.5 0.2 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) Integrase_H2C2 PF17921.1 PIK51039.1 - 2.3e-16 59.7 0.0 2.3e-16 59.7 0.0 2.7 2 0 0 2 2 2 1 Integrase zinc binding domain UCH PF00443.29 PIK51039.1 - 1.4e-05 24.8 0.6 0.00092 18.8 0.6 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-H2C2 PF09337.10 PIK51039.1 - 0.0002 21.5 0.0 0.0002 21.5 0.0 2.4 2 0 0 2 2 2 1 H2C2 zinc finger UCH_1 PF13423.6 PIK51039.1 - 0.0018 17.9 2.9 0.0019 17.8 1.5 1.9 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase CutA1 PF03091.15 PIK51039.1 - 0.065 13.1 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 CutA1 divalent ion tolerance protein rve PF00665.26 PIK51039.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Nup54 PF13874.6 PIK51041.1 - 4.4e-14 52.8 0.2 1e-13 51.6 0.0 1.7 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 ID PF18543.1 PIK51042.1 - 0.2 11.7 0.0 0.56 10.3 0.0 1.7 1 0 0 1 1 1 0 Intracellular delivery domain WW PF00397.26 PIK51042.1 - 0.25 11.5 3.1 0.12 12.4 0.3 2.0 2 0 0 2 2 2 0 WW domain FAST_1 PF06743.15 PIK51043.1 - 1e-12 47.8 5.6 6.9e-11 41.9 0.2 3.0 2 1 0 2 2 2 2 FAST kinase-like protein, subdomain 1 BAR_3 PF16746.5 PIK51043.1 - 0.019 14.7 0.1 0.034 13.9 0.1 1.5 1 1 0 1 1 1 0 BAR domain of APPL family EF-hand_1 PF00036.32 PIK51044.1 - 6.5e-39 128.6 8.5 4.6e-10 38.3 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 PIK51044.1 - 1.9e-33 114.7 1.2 1.8e-15 57.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK51044.1 - 2.9e-31 107.1 8.3 2.6e-13 49.6 0.1 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 PIK51044.1 - 3.1e-28 95.3 4.0 1.2e-09 37.3 0.1 4.4 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 PIK51044.1 - 2.5e-25 86.8 5.3 1.2e-06 27.7 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 PIK51044.1 - 9.1e-14 51.5 0.1 2.2e-09 37.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 PIK51044.1 - 1.1e-07 31.7 0.2 0.012 15.6 0.0 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK51044.1 - 1.4e-06 28.6 0.0 0.032 14.6 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 PIK51044.1 - 1.2e-05 25.2 0.0 0.041 13.9 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 PIK51044.1 - 2.4e-05 24.3 0.4 0.00018 21.5 0.0 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 PIK51044.1 - 8.1e-05 23.4 0.0 0.042 14.7 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain Caleosin PF05042.13 PIK51044.1 - 0.0012 18.8 0.2 0.47 10.4 0.0 3.0 1 1 2 3 3 3 1 Caleosin related protein Dockerin_1 PF00404.18 PIK51044.1 - 0.0013 18.9 5.4 0.15 12.3 0.7 3.0 1 1 2 3 3 3 2 Dockerin type I domain DUF3349 PF11829.8 PIK51044.1 - 0.0018 19.0 0.3 2.2 9.1 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 PIK51044.1 - 0.0019 18.7 0.0 0.86 10.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) RNA_pol_Rpb4 PF03874.16 PIK51044.1 - 0.003 17.9 0.7 1.6 9.0 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 DUF1103 PF06513.11 PIK51044.1 - 0.0038 16.9 2.2 0.0044 16.7 2.2 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Poly_export PF02563.16 PIK51044.1 - 0.012 15.8 0.1 0.88 9.8 0.0 3.0 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein EF-hand_14 PF17959.1 PIK51044.1 - 0.025 14.9 0.1 9.7 6.6 0.0 2.3 1 1 0 2 2 2 0 EF-hand domain TerB PF05099.13 PIK51044.1 - 0.03 14.3 0.4 0.37 10.7 0.0 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB SurA_N_2 PF13623.6 PIK51044.1 - 0.041 13.8 0.4 2.7 7.9 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain MotA_activ PF09114.10 PIK51044.1 - 0.057 13.6 0.3 1 9.6 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 PIK51044.1 - 0.059 12.5 0.1 5.8 6.0 0.1 2.4 1 1 1 2 2 2 0 Cache domain Fe_hyd_lg_C PF02906.14 PIK51044.1 - 0.06 13.0 0.5 0.21 11.2 0.5 1.8 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TetR_C_7 PF14246.6 PIK51044.1 - 0.086 12.9 0.1 7.2 6.7 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain RuvA_C PF07499.13 PIK51044.1 - 0.12 12.8 0.1 12 6.4 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain Spore_III_AB PF09548.10 PIK51044.1 - 0.12 12.4 0.2 0.23 11.6 0.2 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) CMD PF02627.20 PIK51044.1 - 0.3 11.2 1.1 6.6 6.9 0.0 2.8 2 2 2 4 4 3 0 Carboxymuconolactone decarboxylase family SapB_1 PF05184.15 PIK51044.1 - 0.36 10.9 1.6 26 4.9 0.0 3.4 4 0 0 4 4 4 0 Saposin-like type B, region 1 Str_synth PF03088.16 PIK51045.1 - 5.9e-22 77.6 0.0 1.6e-21 76.2 0.0 1.6 2 0 0 2 2 2 1 Strictosidine synthase SGL PF08450.12 PIK51045.1 - 2.2e-13 50.3 0.0 2.8e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 PIK51045.1 - 0.0012 19.0 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Arylesterase PQQ_3 PF13570.6 PIK51046.1 - 0.0036 17.7 0.0 0.17 12.4 0.0 2.4 2 0 0 2 2 2 1 PQQ-like domain DuoxA PF10204.9 PIK51046.1 - 0.081 11.9 0.1 0.15 11.0 0.0 1.5 2 0 0 2 2 2 0 Dual oxidase maturation factor FixQ PF05545.11 PIK51046.1 - 0.34 10.9 1.5 0.62 10.1 1.5 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Rubis-subs-bind PF09273.11 PIK51047.1 - 3.5e-13 50.4 2.1 7.3e-13 49.3 2.1 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 PIK51047.1 - 4.4e-08 33.7 0.0 4.4e-08 33.7 0.0 2.1 2 1 0 2 2 2 1 SET domain Sulfatase PF00884.23 PIK51048.1 - 2.7e-65 220.8 0.0 3.9e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK51048.1 - 2.3e-23 83.3 0.2 5.9e-23 81.9 0.2 1.7 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK51048.1 - 3.9e-06 26.7 0.1 2e-05 24.4 0.1 1.8 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 PIK51048.1 - 0.16 12.3 0.3 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) Alpha-amylase PF00128.24 PIK51049.1 - 2.6e-52 178.5 0.2 1.2e-45 156.6 0.2 2.2 2 0 0 2 2 2 2 Alpha amylase, catalytic domain SLC3A2_N PF16028.5 PIK51049.1 - 7.5e-23 79.9 1.0 1.3e-22 79.2 1.0 1.3 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Trypan_PARP PF05887.11 PIK51049.1 - 0.026 14.5 1.4 0.026 14.5 1.4 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Nucleoside_tran PF01733.18 PIK51050.1 - 7.3e-64 216.1 32.3 2.7e-62 210.9 27.0 3.0 2 1 0 2 2 2 1 Nucleoside transporter RAMP4 PF06624.12 PIK51050.1 - 0.15 12.1 0.3 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 Pkinase_Tyr PF07714.17 PIK51051.1 - 7.4e-51 172.9 0.0 9.3e-51 172.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51051.1 - 5.1e-26 91.6 0.0 5.8e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 PIK51051.1 - 0.049 13.6 0.0 3.4 7.5 0.0 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family ABC1 PF03109.16 PIK51051.1 - 0.19 11.9 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 ABC1 family Alba PF01918.21 PIK51052.1 - 5e-12 45.4 0.1 1e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Alba Ig_3 PF13927.6 PIK51053.1 - 0.00018 22.0 0.0 0.00046 20.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain GAIN PF16489.5 PIK51053.1 - 0.00041 19.8 2.3 0.0063 16.0 0.3 2.7 3 0 0 3 3 3 1 GPCR-Autoproteolysis INducing (GAIN) domain PSI_integrin PF17205.3 PIK51054.1 - 4.4e-12 45.5 9.9 9.2e-12 44.5 9.9 1.5 1 1 0 1 1 1 1 Integrin plexin domain PSI PF01437.25 PIK51054.1 - 0.0067 17.0 10.9 0.013 16.1 10.9 1.5 1 1 0 1 1 1 1 Plexin repeat SGT1 PF07093.11 PIK51054.1 - 0.081 11.3 1.3 0.082 11.3 1.3 1.0 1 0 0 1 1 1 0 SGT1 protein Cwf_Cwc_15 PF04889.12 PIK51054.1 - 0.099 12.4 12.9 0.12 12.1 12.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 PIK51054.1 - 0.22 11.2 1.6 0.35 10.5 1.6 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 PIK51054.1 - 0.28 11.2 4.8 0.38 10.8 4.8 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 PIK51054.1 - 0.37 8.8 1.6 0.46 8.5 1.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 PIK51054.1 - 0.45 9.0 3.3 0.56 8.7 3.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Thioredoxin_3 PF13192.6 PIK51054.1 - 0.85 9.7 5.1 1.4 9.1 4.5 1.6 1 1 1 2 2 2 0 Thioredoxin domain CDC45 PF02724.14 PIK51054.1 - 1.5 7.0 4.9 1.9 6.7 4.9 1.0 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 PIK51054.1 - 2.3 8.7 17.7 3.3 8.2 17.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YL1 PF05764.13 PIK51054.1 - 2.6 8.1 5.3 2.8 8.0 5.3 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Utp14 PF04615.13 PIK51054.1 - 2.7 6.4 7.8 3.5 6.1 7.8 1.0 1 0 0 1 1 1 0 Utp14 protein CENP-B_dimeris PF09026.10 PIK51054.1 - 8.2 6.9 23.3 13 6.3 23.3 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Integrin_alpha2 PF08441.12 PIK51056.1 - 2.4e-62 211.4 0.0 7.1e-62 209.8 0.0 1.7 1 1 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 PIK51056.1 - 8.9e-10 38.5 5.6 2.6e-09 37.0 1.1 3.5 4 0 0 4 4 4 1 FG-GAP repeat VCBS PF13517.6 PIK51056.1 - 5e-06 27.0 0.2 2.7e-05 24.6 0.2 2.4 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK51056.1 - 0.001 19.3 1.1 0.04 14.2 0.2 3.2 3 0 0 3 3 3 1 FG-GAP repeat CCDC84 PF14968.6 PIK51057.1 - 6.5e-76 256.2 20.1 4.8e-39 135.0 7.5 2.0 1 1 0 2 2 2 2 Coiled coil protein 84 fn3 PF00041.21 PIK51058.1 - 8.9e-21 74.0 4.1 1.2e-14 54.5 0.9 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK51058.1 - 9e-07 29.4 3.4 0.0001 22.8 1.2 2.2 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Uroplakin_II PF07353.12 PIK51058.1 - 0.082 12.4 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Uroplakin II fn3 PF00041.21 PIK51059.1 - 4.6e-15 55.7 3.0 9.3e-15 54.8 0.9 2.1 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK51059.1 - 4.6e-06 27.1 1.8 1.4e-05 25.6 0.7 1.9 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain PTP_tm PF18861.1 PIK51059.1 - 0.035 14.1 0.1 0.4 10.7 0.0 2.0 1 1 1 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J fn3 PF00041.21 PIK51060.1 - 4.3e-49 164.8 10.2 1.1e-12 48.1 0.2 4.3 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK51060.1 - 4.7e-17 62.3 10.5 2e-05 25.1 0.4 4.7 3 2 1 4 4 4 3 Purple acid Phosphatase, N-terminal domain DUF4912 PF16258.5 PIK51060.1 - 0.00014 22.0 0.0 0.93 9.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4912) PTP_tm PF18861.1 PIK51060.1 - 0.0031 17.5 0.0 4.5 7.2 0.0 2.7 2 2 0 2 2 2 2 Transmembrane domain of protein tyrosine phosphatase, receptor type J Glyco_hydro38C2 PF17677.1 PIK51060.1 - 0.011 15.8 0.0 7.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF2369 PF10179.9 PIK51060.1 - 0.036 14.5 1.4 71 3.9 0.0 4.4 3 1 1 4 4 4 0 Uncharacterised conserved protein (DUF2369) I-set PF07679.16 PIK51060.1 - 0.042 13.9 0.1 3.4 7.8 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin I-set domain Subtilosin_A PF11420.8 PIK51060.1 - 0.83 9.7 2.6 28 4.8 0.1 3.3 3 0 0 3 3 3 0 Bacteriocin subtilosin A EGF_2 PF07974.13 PIK51061.1 - 1.3e-07 31.9 51.4 2.5e-06 27.7 5.8 5.6 3 2 1 4 4 4 2 EGF-like domain hEGF PF12661.7 PIK51061.1 - 0.00041 20.9 4.9 0.00041 20.9 4.9 6.6 7 1 0 7 7 7 2 Human growth factor-like EGF DSL PF01414.19 PIK51061.1 - 0.0016 18.7 48.9 0.13 12.5 15.4 3.5 2 1 1 3 3 3 3 Delta serrate ligand Laminin_EGF PF00053.24 PIK51061.1 - 0.14 12.4 51.4 0.27 11.4 13.5 5.4 2 1 4 6 6 6 0 Laminin EGF domain PDCD9 PF07147.12 PIK51062.1 - 1.7e-07 30.8 0.1 3.2e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) Ig_3 PF13927.6 PIK51063.1 - 2e-12 47.5 0.0 3.4e-08 34.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK51063.1 - 3.2e-11 43.2 0.0 1.9e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK51063.1 - 4.5e-11 42.8 0.1 4.2e-07 30.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK51063.1 - 2.9e-08 33.9 0.0 5.1e-05 23.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK51063.1 - 0.00034 20.8 1.0 0.062 13.5 0.0 3.1 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK51063.1 - 0.00091 18.7 0.2 1 9.0 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK51064.1 - 2.4e-15 56.9 0.4 1e-10 42.1 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK51064.1 - 1.2e-13 51.0 0.9 2.6e-08 33.9 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK51064.1 - 2.9e-13 49.7 1.0 1.1e-08 35.0 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK51064.1 - 3.5e-10 40.1 0.8 1.9e-05 24.9 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK51064.1 - 1.5e-06 28.4 1.4 0.05 13.8 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK51064.1 - 5.8e-06 26.3 0.2 0.13 12.3 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK51064.1 - 0.00012 21.5 0.7 0.58 9.8 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 PIK51064.1 - 0.00038 20.6 1.1 0.88 9.9 0.1 2.7 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain C2-set PF05790.15 PIK51064.1 - 0.063 13.5 0.1 15 5.8 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin C2-set domain RFX_DNA_binding PF02257.15 PIK51065.1 - 4.1e-15 56.1 0.2 4.1e-15 56.1 0.2 2.0 2 0 0 2 2 2 1 RFX DNA-binding domain CD20 PF04103.15 PIK51066.1 - 1.6 8.8 9.6 0.37 10.9 5.1 2.2 1 1 2 3 3 3 0 CD20-like family RVT_1 PF00078.27 PIK51067.1 - 0.0038 16.8 0.1 0.0058 16.2 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DED PF01335.21 PIK51068.1 - 3e-12 46.6 1.5 3e-12 46.6 1.5 3.5 3 2 0 3 3 3 1 Death effector domain zf-B_box PF00643.24 PIK51068.1 - 6.7e-06 26.2 6.3 1.5e-05 25.1 6.3 1.6 1 0 0 1 1 1 1 B-box zinc finger zf-B_box PF00643.24 PIK51070.1 - 3.7e-06 27.0 6.1 5.9e-06 26.3 6.1 1.4 1 0 0 1 1 1 1 B-box zinc finger SIR2 PF02146.17 PIK51070.1 - 0.095 12.6 3.6 0.045 13.7 1.2 1.6 1 1 0 1 1 1 0 Sir2 family IBR PF01485.21 PIK51070.1 - 0.24 11.7 5.3 0.58 10.4 5.3 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain FliT PF05400.13 PIK51070.1 - 6 7.8 12.4 24 5.8 11.3 2.2 1 1 1 2 2 2 0 Flagellar protein FliT MIF4G PF02854.19 PIK51071.1 - 1.9e-11 44.0 5.7 4e-11 43.0 5.7 1.5 1 1 0 1 1 1 1 MIF4G domain UcrQ PF02939.16 PIK51071.1 - 0.069 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 UcrQ family MIF4G PF02854.19 PIK51072.1 - 1.5e-55 188.1 32.0 2.1e-43 148.4 11.9 3.8 3 1 0 3 3 3 3 MIF4G domain W2 PF02020.18 PIK51072.1 - 8.2e-14 51.5 0.1 5.8e-12 45.6 0.1 3.3 2 1 1 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon AA_permease_2 PF13520.6 PIK51073.1 - 1.8e-31 109.4 32.6 1.8e-31 109.4 32.6 1.9 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 PIK51073.1 - 4e-24 85.1 33.8 4e-24 85.1 33.8 1.9 2 1 0 2 2 2 1 Amino acid permease UPF0242 PF06785.11 PIK51073.1 - 0.072 13.2 1.0 0.17 12.0 0.2 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4599 PF15371.6 PIK51074.1 - 0.17 12.4 0.4 1.2 9.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4599) Antistasin PF02822.14 PIK51074.1 - 0.18 12.5 2.9 1.4 9.6 1.1 2.5 1 1 1 2 2 2 0 Antistasin family SH2 PF00017.24 PIK51075.1 - 9.5e-14 51.3 0.0 1.8e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 PIK51075.1 - 0.086 12.2 0.1 0.23 10.8 0.0 1.6 1 1 1 2 2 2 0 SH2 domain PID PF00640.23 PIK51076.1 - 6.3e-08 32.8 0.1 1.3e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Com_YlbF PF06133.11 PIK51076.1 - 0.019 15.6 2.1 0.037 14.6 2.1 1.4 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA SCO1-SenC PF02630.14 PIK51077.1 - 2.7e-48 163.3 0.0 3.8e-48 162.8 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 PIK51077.1 - 1.7e-07 31.2 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 PIK51077.1 - 0.00022 21.5 0.0 0.00044 20.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 PIK51077.1 - 0.097 12.4 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 Redoxin ATG16 PF08614.11 PIK51078.1 - 0.0088 16.3 12.3 0.0088 16.3 12.3 7.8 3 2 5 8 8 8 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 PIK51078.1 - 3.1 6.6 137.1 0.14 11.1 25.7 6.8 2 2 3 6 6 6 0 Spc7 kinetochore protein GAS PF13851.6 PIK51079.1 - 0.0042 16.5 121.9 0.051 12.9 22.2 7.2 1 1 6 7 7 7 4 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK51079.1 - 0.0048 15.8 120.2 0.0055 15.6 28.8 5.1 1 1 4 5 5 5 5 Spc7 kinetochore protein HMMR_N PF15905.5 PIK51079.1 - 0.0066 16.0 22.7 0.0066 16.0 22.7 5.4 1 1 2 4 4 4 2 Hyaluronan mediated motility receptor N-terminal TPR_MLP1_2 PF07926.12 PIK51079.1 - 0.014 15.5 21.2 0.014 15.5 21.2 6.9 2 2 5 7 7 7 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.11 PIK51079.1 - 0.046 12.6 116.0 0.027 13.3 34.9 3.1 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like HAUS-augmin3 PF14932.6 PIK51079.1 - 0.68 9.5 100.4 0.15 11.6 16.0 5.2 1 1 4 5 5 5 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 PIK51079.1 - 1 9.9 137.2 0.59 10.7 13.9 7.7 1 1 7 8 8 8 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 PIK51079.1 - 2.7 8.0 132.3 0.17 11.9 19.5 6.4 1 1 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vac_Fusion PF02346.16 PIK51079.1 - 5.2 6.8 11.2 4.2 7.1 3.5 4.0 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Rootletin PF15035.6 PIK51080.1 - 9.1e-67 224.7 61.4 1.4e-64 217.6 32.8 5.0 4 1 1 5 5 5 3 Ciliary rootlet component, centrosome cohesion GAS PF13851.6 PIK51080.1 - 0.00021 20.7 16.1 0.00021 20.7 16.1 5.5 2 2 1 5 5 5 1 Growth-arrest specific micro-tubule binding FPP PF05911.11 PIK51080.1 - 0.0014 17.0 4.9 0.0014 17.0 4.9 4.3 2 1 2 4 4 4 1 Filament-like plant protein, long coiled-coil DivIC PF04977.15 PIK51080.1 - 0.0014 18.4 2.9 0.0014 18.4 2.9 7.6 5 2 3 9 9 9 3 Septum formation initiator HMMR_N PF15905.5 PIK51080.1 - 0.002 17.7 14.4 0.002 17.7 14.4 4.9 2 1 2 5 5 5 1 Hyaluronan mediated motility receptor N-terminal ERM PF00769.19 PIK51080.1 - 0.0024 17.7 20.1 0.0024 17.7 20.1 3.8 2 1 1 3 3 3 1 Ezrin/radixin/moesin family DUF2681 PF10883.8 PIK51080.1 - 0.01 16.2 2.1 0.01 16.2 2.1 5.9 5 1 1 6 6 6 0 Protein of unknown function (DUF2681) Lipoprotein_2 PF00921.17 PIK51080.1 - 3.2 7.2 15.4 0.2 11.2 1.6 3.2 3 0 0 3 3 3 0 Borrelia lipoprotein YabA PF06156.13 PIK51080.1 - 7.8 7.2 74.7 0.16 12.6 4.3 7.6 3 3 5 8 8 8 0 Initiation control protein YabA Pex2_Pex12 PF04757.14 PIK51081.1 - 1e-32 113.6 4.5 1.5e-32 113.0 4.5 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 PIK51081.1 - 1e-08 34.9 7.8 1.6e-08 34.3 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK51081.1 - 3.9e-06 26.9 9.3 6.1e-06 26.3 9.3 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK51081.1 - 8.2e-06 25.6 3.2 1.2e-05 25.0 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK51081.1 - 1e-05 25.5 5.8 1.8e-05 24.7 5.8 1.4 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK51081.1 - 2.3e-05 24.2 5.1 3.5e-05 23.6 5.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK51081.1 - 4.6e-05 23.7 7.5 7.6e-05 23.0 7.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK51081.1 - 8.3e-05 22.3 7.8 0.00014 21.6 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 PIK51081.1 - 0.021 14.7 2.3 0.047 13.6 2.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 PIK51081.1 - 0.022 14.7 8.9 0.066 13.2 9.0 1.7 1 1 1 2 2 2 0 zinc-RING finger domain HpcH_HpaI PF03328.14 PIK51081.1 - 0.038 13.1 0.1 0.33 10.1 0.1 2.0 2 0 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family zf-RING_10 PF16685.5 PIK51081.1 - 0.11 12.7 2.3 0.21 11.8 2.3 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 PIK51081.1 - 0.11 12.7 8.1 0.29 11.4 8.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain DZR PF12773.7 PIK51081.1 - 1.7 8.7 6.8 5.7 7.1 6.9 1.8 1 1 0 1 1 1 0 Double zinc ribbon WAP PF00095.21 PIK51082.1 - 1.1e-07 32.1 19.5 1.6e-07 31.6 19.5 1.3 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Stealth_CR4 PF17103.5 PIK51082.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Vault PF01505.18 PIK51082.1 - 0.096 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Major Vault Protein repeat domain Kelch_1 PF01344.25 PIK51083.1 - 9.1e-36 121.2 1.0 6.8e-09 35.2 0.0 5.5 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 PIK51083.1 - 5.5e-25 86.8 0.0 4.3e-05 23.6 0.0 5.3 3 2 2 5 5 5 5 Kelch motif Kelch_2 PF07646.15 PIK51083.1 - 1.8e-19 68.8 0.1 0.0064 16.4 0.0 5.4 4 1 1 5 5 5 5 Kelch motif Kelch_3 PF13415.6 PIK51083.1 - 3.3e-19 68.7 0.0 1.5e-05 25.1 0.0 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK51083.1 - 1.2e-17 63.7 0.0 2.4e-05 24.3 0.0 4.6 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK51083.1 - 1e-14 54.1 0.3 6.7e-05 22.8 0.0 4.6 5 0 0 5 5 5 3 Kelch motif RAG2 PF03089.14 PIK51083.1 - 0.0031 16.6 0.0 0.0085 15.1 0.0 1.7 1 1 1 2 2 2 1 Recombination activating protein 2 BCAS2 PF05700.11 PIK51084.1 - 1.3e-71 240.6 9.3 1.3e-71 240.6 9.3 1.4 2 0 0 2 2 2 1 Breast carcinoma amplified sequence 2 (BCAS2) EzrA PF06160.12 PIK51084.1 - 0.00047 18.5 10.5 0.00072 17.9 10.5 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA HrpB2 PF09487.10 PIK51084.1 - 0.067 13.6 2.3 4.3 7.8 0.0 2.9 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB2) Golgin_A5 PF09787.9 PIK51084.1 - 0.083 12.3 19.8 0.13 11.7 19.8 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 N6_N4_Mtase PF01555.18 PIK51084.1 - 0.2 11.3 3.6 0.3 10.7 3.6 1.2 1 0 0 1 1 1 0 DNA methylase FlaC_arch PF05377.11 PIK51084.1 - 0.88 10.0 10.0 3.5 8.1 0.1 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) PilJ PF13675.6 PIK51084.1 - 1.5 8.9 5.9 5.2 7.1 0.4 2.9 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term BLOC1_2 PF10046.9 PIK51084.1 - 2 8.8 10.1 1.1 9.6 2.9 2.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PIEZO PF15917.5 PIK51084.1 - 2.8 7.3 16.7 2.2 7.7 14.8 1.7 1 1 1 2 2 2 0 Piezo PRKG1_interact PF15898.5 PIK51084.1 - 3 8.8 24.9 23 6.0 12.8 3.2 1 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Borrelia_P83 PF05262.11 PIK51084.1 - 4.2 5.8 17.9 7 5.0 17.9 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF726 PF05277.12 PIK51085.1 - 1.5e-77 260.9 11.8 2.9e-75 253.4 0.1 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF726) DUF900 PF05990.12 PIK51085.1 - 0.022 14.3 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF5371 PF17341.2 PIK51085.1 - 0.068 13.4 0.5 0.41 10.9 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5371) DUF3089 PF11288.8 PIK51085.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) GYF PF02213.16 PIK51086.1 - 1.9e-10 40.2 0.1 5e-10 38.9 0.1 1.7 1 0 0 1 1 1 1 GYF domain Alpha-amylase_N PF02903.14 PIK51088.1 - 0.0024 18.0 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Alpha amylase, N-terminal ig-like domain Atg8 PF02991.16 PIK51089.1 - 1.4e-49 166.5 0.1 1.6e-49 166.4 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 PIK51089.1 - 5.7e-08 33.1 0.0 7.1e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 3HCDH_N PF02737.18 PIK51091.1 - 4e-60 202.8 0.1 6.7e-60 202.0 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 PIK51091.1 - 1.9e-34 119.1 0.0 3.6e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 PIK51091.1 - 1.7e-31 108.7 0.0 7.3e-23 81.0 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 PIK51091.1 - 1.7e-18 67.3 1.0 2.5e-18 66.7 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase NAD_Gly3P_dh_N PF01210.23 PIK51091.1 - 0.00026 21.0 0.0 0.00061 19.8 0.0 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 PIK51091.1 - 0.057 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_S49 PF01343.18 PIK51091.1 - 0.069 13.1 0.0 7.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 UDPG_MGDP_dh_N PF03721.14 PIK51091.1 - 0.075 12.6 0.3 0.18 11.4 0.3 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 PIK51091.1 - 0.081 13.5 0.3 0.22 12.1 0.3 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sulfatase PF00884.23 PIK51092.1 - 3.3e-67 227.1 0.1 4.5e-67 226.6 0.1 1.1 1 0 0 1 1 1 1 Sulfatase DUF4994 PF16385.5 PIK51092.1 - 0.0024 17.7 0.0 0.0098 15.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 PIK51092.1 - 0.041 14.6 0.0 0.12 13.1 0.0 1.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase TTL PF03133.15 PIK51093.1 - 1.4e-49 168.8 0.0 2e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK51093.1 - 4.9e-13 48.9 0.1 1.1e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK51093.1 - 0.0027 17.0 0.0 0.16 11.2 0.0 2.5 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp PDZ PF00595.24 PIK51094.1 - 8.2e-56 186.3 15.3 1.2e-16 60.8 0.5 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK51094.1 - 4.2e-27 93.8 8.0 1.3e-06 28.1 0.3 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK51094.1 - 4e-16 59.1 7.3 0.00078 19.7 0.4 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_4 PF17816.1 PIK51094.1 - 0.019 15.3 2.1 6.6 7.2 0.0 4.6 4 1 1 5 5 5 0 PDZ domain Tricorn_PDZ PF14685.6 PIK51094.1 - 0.038 14.0 4.1 14 5.7 0.1 3.8 4 0 0 4 4 4 0 Tricorn protease PDZ domain PDZ PF00595.24 PIK51095.1 - 6.5e-88 289.2 29.0 2.8e-14 53.2 0.2 7.4 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 PIK51095.1 - 1.4e-46 156.2 16.9 9.2e-09 35.0 0.3 7.4 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 PIK51095.1 - 1.5e-31 108.5 18.6 8.8e-05 22.8 1.8 7.4 7 0 0 7 7 7 7 PDZ domain L27_2 PF09045.10 PIK51095.1 - 6.4e-08 32.4 2.3 1.3e-07 31.5 2.3 1.5 1 0 0 1 1 1 1 L27_2 Tricorn_PDZ PF14685.6 PIK51095.1 - 7.4e-05 22.6 6.2 1.7 8.7 0.1 5.5 5 0 0 5 5 5 1 Tricorn protease PDZ domain PDZ_4 PF17816.1 PIK51095.1 - 0.0011 19.4 0.4 0.29 11.5 0.0 4.1 4 0 0 4 4 4 1 PDZ domain L27_1 PF09058.10 PIK51095.1 - 0.015 15.3 0.1 0.037 14.0 0.1 1.6 1 0 0 1 1 1 0 L27_1 SDA1 PF05285.12 PIK51095.1 - 0.4 10.1 18.3 0.96 8.8 18.3 1.6 1 0 0 1 1 1 0 SDA1 Kelch_1 PF01344.25 PIK51096.1 - 1.2e-81 268.1 4.9 3.1e-16 58.7 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK51096.1 - 1e-45 152.6 0.5 4.2e-09 36.4 0.0 6.4 2 2 4 6 6 6 6 Kelch motif BTB PF00651.31 PIK51096.1 - 4.8e-34 116.9 1.0 8.8e-34 116.1 1.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 PIK51096.1 - 2.2e-29 101.1 3.0 9e-05 22.7 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain BACK PF07707.15 PIK51096.1 - 2.9e-25 88.3 1.5 9e-25 86.8 0.1 2.4 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 PIK51096.1 - 8.2e-25 85.8 0.8 0.0019 18.1 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 PIK51096.1 - 3.5e-23 81.4 0.2 3.7e-05 23.6 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK51096.1 - 3.3e-05 23.7 2.3 0.19 11.7 0.0 5.0 5 0 0 5 5 5 1 Kelch motif Autophagy_act_C PF03987.15 PIK51097.1 - 1.7e-19 70.1 1.9 2.7e-19 69.5 1.3 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain FAM176 PF14851.6 PIK51097.1 - 0.24 11.1 4.6 0.38 10.4 4.6 1.3 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 PIK51097.1 - 0.78 7.7 1.9 0.98 7.4 1.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SSF PF00474.17 PIK51100.1 - 6.1e-37 127.5 11.9 7.6e-37 127.1 11.9 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family SET PF00856.28 PIK51101.1 - 6.7e-14 52.6 1.0 1.6e-12 48.1 0.2 3.0 2 1 0 2 2 2 1 SET domain Y_phosphatase PF00102.27 PIK51103.1 - 2.9e-111 370.7 0.8 2e-50 171.5 0.0 3.1 3 0 0 3 3 3 3 Protein-tyrosine phosphatase ECSIT_C PF14784.6 PIK51103.1 - 0.0028 18.0 0.7 0.0069 16.7 0.7 1.7 1 0 0 1 1 1 1 C-terminal domain of the ECSIT protein DSPc PF00782.20 PIK51103.1 - 0.021 14.6 0.4 0.13 12.1 0.0 2.4 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK51103.1 - 0.11 12.4 0.0 9 6.2 0.0 2.4 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF1992 PF09350.10 PIK51104.1 - 4.1e-19 68.5 0.0 1.4e-18 66.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DnaJ PF00226.31 PIK51104.1 - 8.9e-07 29.0 0.5 8.9e-07 29.0 0.5 2.2 2 0 0 2 2 2 1 DnaJ domain Phage_Gp23 PF10669.9 PIK51104.1 - 0.043 14.1 1.4 0.043 14.1 1.4 3.1 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) DUF4632 PF15451.6 PIK51104.1 - 0.52 10.4 2.5 5.2 7.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4632) Thiolase_N PF00108.23 PIK51106.1 - 2.1e-12 47.0 0.0 2.8e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 PIK51106.1 - 9.2e-06 25.4 0.4 0.078 12.5 0.1 2.2 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 PIK51106.1 - 4.5e-05 22.3 0.0 6.3e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.10 PIK51106.1 - 0.0015 18.4 0.2 0.0046 16.8 0.0 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Mur_ligase_C PF02875.21 PIK51106.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain SCVP PF17619.2 PIK51107.1 - 0.053 14.4 2.5 26 5.7 0.1 4.3 4 1 1 5 5 5 0 Secreted clade V proteins ELF PF03317.13 PIK51107.1 - 0.72 9.9 3.8 8.2 6.4 0.1 3.8 4 0 0 4 4 4 0 ELF protein Cuticle_2 PF08184.11 PIK51107.1 - 5.1 7.2 14.4 1.2e+02 2.8 0.2 7.6 6 3 0 6 6 6 0 Cuticle protein 7 isoform family ubiquitin PF00240.23 PIK51108.1 - 2.3e-09 36.9 1.1 0.00063 19.4 0.0 3.4 3 0 0 3 3 3 2 Ubiquitin family Ras PF00071.22 PIK51109.1 - 2.5e-26 92.2 0.1 3.3e-26 91.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK51109.1 - 9.1e-15 54.9 0.0 1.6e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK51109.1 - 1.4e-06 28.3 0.0 2.9e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 PIK51109.1 - 9.7e-06 25.1 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK51109.1 - 0.00057 19.8 1.2 0.24 11.3 0.2 2.1 1 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 PIK51109.1 - 0.035 13.3 1.6 0.2 10.8 0.3 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 PIK51109.1 - 0.054 13.6 5.2 0.34 11.0 0.3 2.9 3 1 1 4 4 4 0 Dynamin family OKR_DC_1_N PF03709.15 PIK51109.1 - 0.059 13.7 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Neur_chan_memb PF02932.16 PIK51110.1 - 7e-05 23.0 0.3 0.00013 22.1 0.3 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region NT-C2 PF10358.9 PIK51110.1 - 0.0039 16.9 0.0 0.0092 15.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Phage_holin_6_1 PF09682.10 PIK51110.1 - 0.092 13.2 0.7 8.9 6.8 0.2 2.8 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Connexin PF00029.19 PIK51110.1 - 0.45 10.2 10.7 3.7 7.2 10.7 2.2 1 1 0 1 1 1 0 Connexin DENN PF02141.21 PIK51113.1 - 6.1e-58 195.8 2.9 1.1e-57 195.0 2.9 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 PIK51113.1 - 3.7e-14 53.2 0.1 1.1e-13 51.7 0.1 1.9 1 0 0 1 1 1 1 uDENN domain DUF2464 PF10240.9 PIK51113.1 - 1.2e-06 28.3 0.1 0.0093 15.6 0.0 2.6 2 1 1 3 3 3 2 Multivesicular body subunit 12 dDENN PF03455.19 PIK51113.1 - 2.4e-06 27.4 2.9 4.9e-06 26.4 2.9 1.6 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 PIK51113.1 - 1.7e-05 24.9 0.1 3.9e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 PIK51113.1 - 0.069 13.4 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 PIK51113.1 - 0.19 11.8 0.3 0.42 10.7 0.3 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain TPR_19 PF14559.6 PIK51116.1 - 4.9e-13 49.4 2.8 0.0055 17.2 0.0 5.9 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51116.1 - 6.1e-12 46.0 0.0 0.00053 20.6 0.0 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51116.1 - 5.3e-10 38.6 5.6 0.47 10.7 0.0 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK51116.1 - 1.7e-08 34.6 0.4 0.098 13.5 0.1 7.3 5 3 3 8 8 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK51116.1 - 1.9e-08 33.8 2.4 0.0067 16.1 0.0 5.2 6 0 0 6 6 6 2 TPR repeat TPR_1 PF00515.28 PIK51116.1 - 3.1e-08 33.1 5.6 0.026 14.3 0.0 6.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51116.1 - 3.2e-08 33.1 6.3 0.026 14.7 0.0 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51116.1 - 5.5e-07 29.7 2.6 0.82 9.9 0.0 4.4 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 PIK51116.1 - 4.8e-06 26.2 0.0 0.036 13.7 0.0 3.1 3 0 0 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 PIK51116.1 - 0.002 18.6 5.1 20 6.1 0.0 6.4 8 0 0 8 8 7 0 Tetratricopeptide repeat LppC PF04348.13 PIK51116.1 - 0.0067 15.3 1.0 0.011 14.5 1.0 1.3 1 0 0 1 1 1 1 LppC putative lipoprotein TPR_4 PF07721.14 PIK51116.1 - 0.01 16.4 0.1 14 6.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4363 PF14276.6 PIK51116.1 - 0.54 10.4 5.5 1.6 8.9 0.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) TPR_1 PF00515.28 PIK51117.1 - 5.5e-22 76.6 15.0 0.0002 21.0 0.0 9.1 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51117.1 - 2.5e-21 74.0 6.1 0.00012 21.9 0.1 8.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51117.1 - 1.6e-16 59.1 6.3 0.0019 18.2 0.1 7.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51117.1 - 1.6e-15 57.5 0.0 2.9e-10 40.6 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK51117.1 - 2.9e-15 55.7 0.1 1e-05 25.9 0.0 6.8 4 1 4 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK51117.1 - 5.4e-15 54.8 0.1 0.0029 17.2 0.0 6.9 6 1 1 7 7 7 4 TPR repeat TPR_17 PF13431.6 PIK51117.1 - 2.6e-14 52.5 1.3 3.3e-05 23.9 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK51117.1 - 2.3e-09 37.4 2.6 0.0092 16.3 0.0 5.3 6 2 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK51117.1 - 3.7e-07 30.4 2.1 0.68 10.7 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51117.1 - 3.3e-06 27.2 2.3 0.00095 19.3 0.4 3.6 3 1 1 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK51117.1 - 6.1e-06 26.7 0.9 0.0017 18.8 0.0 4.3 3 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51117.1 - 1.5e-05 25.0 0.0 3.8 7.7 0.0 4.8 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK51117.1 - 0.00012 21.8 7.4 0.092 12.8 0.0 5.9 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK51117.1 - 0.00066 19.5 1.7 13 5.8 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 PIK51117.1 - 0.0012 18.0 0.1 0.3 10.1 0.0 2.2 2 0 0 2 2 2 2 Coatomer WD associated region DUF3669 PF12417.8 PIK51117.1 - 0.0022 18.1 0.0 6.1 7.1 0.0 3.4 3 0 0 3 3 3 1 Zinc finger protein TOM20_plant PF06552.12 PIK51117.1 - 0.02 14.7 0.1 0.37 10.5 0.0 2.3 2 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 ANAPC5 PF12862.7 PIK51117.1 - 0.032 14.3 0.0 0.64 10.1 0.0 2.9 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_20 PF14561.6 PIK51117.1 - 0.056 13.8 0.0 0.17 12.2 0.0 1.9 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_21 PF09976.9 PIK51117.1 - 0.067 12.9 0.1 0.53 10.0 0.1 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain Flu_M1 PF00598.19 PIK51117.1 - 0.073 12.6 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M1) TPR_15 PF13429.6 PIK51117.1 - 0.12 11.6 0.0 0.53 9.4 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK51118.1 - 9.6e-08 32.2 11.1 0.00029 21.1 0.7 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK51118.1 - 4.7e-07 30.1 5.2 0.17 12.8 0.0 5.9 5 1 1 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51118.1 - 7.4e-06 26.1 3.7 7.4e-06 26.1 3.7 5.0 5 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK51118.1 - 1.5e-05 25.4 12.3 0.13 12.8 1.1 6.6 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51118.1 - 1.8e-05 24.5 16.4 0.016 15.3 1.3 6.2 8 1 0 8 8 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51118.1 - 0.00081 20.0 1.5 1.4 9.6 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK51118.1 - 0.0027 16.9 2.3 0.89 8.7 0.2 3.3 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK51118.1 - 0.0035 17.1 15.7 0.24 11.3 1.5 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51118.1 - 0.0062 16.7 6.8 2.5 8.3 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51118.1 - 0.023 14.9 6.8 5.9 7.4 0.4 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK51118.1 - 0.042 14.5 13.9 1.6 9.5 0.3 6.6 7 1 0 7 7 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK51118.1 - 0.11 12.6 9.2 0.47 10.6 0.5 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK51118.1 - 0.48 10.9 3.3 1.1e+02 3.5 0.1 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat MRP-S27 PF10037.9 PIK51119.1 - 6.4e-64 216.2 6.0 1.6e-61 208.4 6.0 2.0 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 DMP12 PF16779.5 PIK51119.1 - 0.0016 18.4 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 DNA-mimic protein PPR_3 PF13812.6 PIK51119.1 - 0.0055 16.8 0.0 0.025 14.7 0.1 2.1 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 PIK51119.1 - 0.0061 16.7 0.1 0.015 15.5 0.1 1.6 1 0 0 1 1 1 1 PPR repeat family PSII_Pbs27 PF13326.6 PIK51119.1 - 0.042 14.2 3.3 0.27 11.6 0.2 2.4 1 1 0 2 2 2 0 Photosystem II Pbs27 PPR_1 PF12854.7 PIK51119.1 - 0.079 12.7 0.2 0.27 11.0 0.0 2.0 2 0 0 2 2 2 0 PPR repeat DUF2555 PF10742.9 PIK51119.1 - 0.1 12.5 0.3 0.57 10.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) PTH2 PF01981.16 PIK51119.1 - 0.85 9.9 2.9 5.7 7.2 0.7 2.4 1 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 WD40 PF00400.32 PIK51120.1 - 1e-38 130.6 16.6 6.4e-07 30.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK51120.1 - 9.1e-14 51.5 0.1 0.06 13.6 0.1 5.1 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK51120.1 - 2.7e-05 23.7 0.0 0.69 9.2 0.0 3.5 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 PIK51120.1 - 0.00058 18.9 0.1 4.4 6.2 0.0 3.8 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein TPR_12 PF13424.6 PIK51121.1 - 0.0098 16.2 1.8 0.23 11.8 0.7 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK51121.1 - 0.075 12.9 1.0 5.4 7.0 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK51122.1 - 1.2e-16 60.8 4.7 3.5e-07 30.4 1.4 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51122.1 - 3.2e-10 39.3 19.3 0.1 12.7 1.2 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat SNAP PF14938.6 PIK51122.1 - 3.6e-10 39.7 15.7 9.2e-09 35.1 7.8 3.2 1 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 PIK51122.1 - 1.1e-09 38.3 3.2 0.24 12.3 0.4 6.5 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51122.1 - 1.8e-07 30.8 19.5 0.019 15.1 0.4 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51122.1 - 3.7e-06 27.5 7.0 0.0062 17.2 0.6 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK51122.1 - 5.1e-06 26.2 5.8 0.22 11.6 0.1 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK51122.1 - 7.9e-06 25.5 1.2 9.2e-05 22.0 1.4 2.1 1 1 1 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 PIK51122.1 - 3.5e-05 24.2 10.0 15 6.5 0.6 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK51122.1 - 6e-05 22.8 9.3 0.0014 18.4 6.6 3.0 2 2 0 2 2 2 1 26S proteasome subunit RPN7 TPR_1 PF00515.28 PIK51122.1 - 0.00019 21.1 22.3 0.098 12.5 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK51122.1 - 0.00023 20.9 7.5 0.99 9.4 0.2 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51122.1 - 0.0014 18.8 11.9 0.36 11.1 0.1 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 PIK51122.1 - 0.013 15.8 4.9 0.77 10.1 0.6 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK51122.1 - 0.023 14.4 8.4 27 4.5 0.3 5.5 5 0 0 5 5 5 0 TPR repeat TPR_17 PF13431.6 PIK51122.1 - 0.023 15.1 2.4 17 6.1 0.1 4.5 6 1 0 6 6 4 0 Tetratricopeptide repeat DUF1722 PF08349.11 PIK51122.1 - 0.072 13.4 1.1 3.6 7.9 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) Halo_GVPC PF05465.13 PIK51122.1 - 0.13 12.5 1.8 3.7 7.9 0.1 2.6 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat DUF4810 PF16068.5 PIK51122.1 - 0.39 11.3 4.2 1.5 9.4 0.9 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF4810) TPR_21 PF09976.9 PIK51122.1 - 0.4 10.3 8.0 4 7.1 5.4 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain MIT PF04212.18 PIK51122.1 - 0.5 10.5 12.7 6.5 6.9 0.3 4.7 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain ANAPC5 PF12862.7 PIK51122.1 - 1.9 8.6 7.9 62 3.7 6.5 3.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 Hydrolase_4 PF12146.8 PIK51123.1 - 7.9e-14 51.5 0.0 4.8e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK51123.1 - 4.5e-07 30.7 0.6 3.4e-05 24.5 0.2 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 PIK51123.1 - 4.6e-07 29.8 0.5 0.0053 16.4 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK51123.1 - 7e-06 25.7 0.0 0.00017 21.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 PIK51123.1 - 0.00064 19.3 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 PIK51123.1 - 0.001 18.8 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 PIK51123.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) UPF0227 PF05728.12 PIK51123.1 - 0.0042 17.1 0.0 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Asp2 PF16929.5 PIK51123.1 - 0.022 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_2 PF02230.16 PIK51123.1 - 0.031 14.1 0.0 0.095 12.5 0.0 1.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF818 PF05677.12 PIK51123.1 - 0.086 11.8 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) TPR_1 PF00515.28 PIK51124.1 - 8.3e-15 53.9 0.9 0.00031 20.4 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 PIK51124.1 - 2e-13 50.5 0.0 6.5e-13 48.8 0.0 1.9 2 0 0 2 2 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 PIK51124.1 - 5.3e-12 44.9 0.7 0.00034 20.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK51124.1 - 1e-11 44.3 0.1 0.004 16.8 0.0 3.7 4 0 0 4 4 4 3 TPR repeat TPR_8 PF13181.6 PIK51124.1 - 3e-09 36.3 1.1 0.057 13.7 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK51124.1 - 7.6e-06 26.3 0.0 0.76 10.8 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat DUF3856 PF12968.7 PIK51124.1 - 7.8e-05 22.8 0.2 0.00023 21.2 0.1 1.9 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 PIK51124.1 - 0.00029 21.0 0.1 0.037 14.4 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK51124.1 - 0.00034 21.1 0.2 0.0048 17.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51124.1 - 0.00037 20.6 0.0 0.00085 19.4 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51124.1 - 0.00064 20.3 0.0 0.035 14.7 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK51124.1 - 0.0059 15.6 1.5 0.0059 15.6 1.5 2.3 2 0 0 2 2 1 1 NMDA receptor-regulated protein 1 HMMR_C PF15908.5 PIK51124.1 - 0.0062 16.8 2.5 0.0062 16.8 2.5 2.7 2 1 1 3 3 2 1 Hyaluronan mediated motility receptor C-terminal TPR_7 PF13176.6 PIK51124.1 - 0.01 15.8 0.0 14 6.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK51124.1 - 0.036 14.1 2.3 0.23 11.6 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat EssA PF10661.9 PIK51124.1 - 5.7 6.8 22.7 0.15 11.9 1.0 2.4 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA N1221 PF07923.13 PIK51125.1 - 0.09 11.9 1.0 0.23 10.6 1.0 1.7 1 0 0 1 1 1 0 N1221-like protein HAT PF02184.16 PIK51126.1 - 0.22 11.5 0.2 0.82 9.7 0.1 1.9 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat E1-E2_ATPase PF00122.20 PIK51127.1 - 1.7e-22 79.8 7.4 7.3e-17 61.5 0.0 3.7 2 1 2 4 4 4 2 E1-E2 ATPase P5-ATPase PF12409.8 PIK51127.1 - 5.9e-22 78.1 0.0 1.8e-21 76.5 0.0 1.8 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 PIK51127.1 - 1.5e-13 51.5 0.0 1.9e-08 34.9 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK51127.1 - 8e-07 29.1 0.0 1.8e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 PIK51127.1 - 0.00057 19.5 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus RT_RNaseH_2 PF17919.1 PIK51128.1 - 1e-37 128.1 0.0 1.4e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK51128.1 - 5.5e-26 90.9 0.0 8e-26 90.4 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HAP1_N PF04849.13 PIK51130.1 - 0.0024 17.2 19.4 0.0033 16.7 19.4 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region CorA PF01544.18 PIK51130.1 - 0.034 13.4 7.2 0.058 12.7 7.2 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein MIP-T3 PF10243.9 PIK51130.1 - 0.051 13.6 0.9 0.12 12.3 0.9 1.6 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CH-like domain Phage_tail_APC PF16778.5 PIK51130.1 - 0.082 12.8 0.3 0.23 11.4 0.3 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein TMF_TATA_bd PF12325.8 PIK51130.1 - 0.89 9.8 16.9 0.43 10.8 11.6 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding LMBR1 PF04791.16 PIK51130.1 - 0.99 8.2 4.8 1.1 8.0 4.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Spc7 PF08317.11 PIK51130.1 - 1.1 8.1 19.4 1.3 7.8 18.9 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 PIK51130.1 - 1.3 9.1 9.0 0.26 11.3 3.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 PIK51130.1 - 1.5 6.6 7.6 1.8 6.4 7.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 PIK51130.1 - 1.6 9.0 7.4 0.97 9.7 2.9 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DASH_Dam1 PF08653.10 PIK51130.1 - 1.9 8.3 5.1 40 4.1 0.4 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 SlyX PF04102.12 PIK51130.1 - 2 9.1 28.0 0.24 12.0 3.7 3.9 2 1 2 4 4 4 0 SlyX TPD52 PF04201.15 PIK51130.1 - 2.4 7.8 9.5 1.4 8.6 0.1 2.4 2 0 0 2 2 2 0 Tumour protein D52 family DUF1043 PF06295.12 PIK51130.1 - 3.8 7.5 15.6 13 5.8 15.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF724 PF05266.14 PIK51130.1 - 4.2 7.2 14.8 2.3 8.0 3.8 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Baculo_PEP_C PF04513.12 PIK51130.1 - 6 6.9 12.8 18 5.4 9.1 2.8 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.7 PIK51130.1 - 6.6 6.9 21.2 0.82 9.8 16.7 1.7 2 0 0 2 2 2 0 Tropomyosin like UPF0242 PF06785.11 PIK51130.1 - 8.2 6.5 19.0 8.5 6.4 16.9 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 PIK51130.1 - 9.8 5.4 23.8 0.4 9.9 11.5 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Voltage_CLC PF00654.20 PIK51131.1 - 1.6e-94 317.1 26.1 2.3e-94 316.6 26.1 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel TAT_signal PF10518.9 PIK51131.1 - 0.91 9.5 10.9 0.17 11.8 5.0 2.8 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence 7tm_2 PF00002.24 PIK51132.1 - 0.073 12.3 1.6 0.097 11.9 1.6 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) 7tm_2 PF00002.24 PIK51133.1 - 7.7e-23 81.0 9.3 1.3e-22 80.3 9.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK51133.1 - 2.9e-10 40.5 3.5 6.2e-10 39.4 0.4 2.6 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Ig_2 PF13895.6 PIK51133.1 - 5.4e-05 23.4 0.5 0.00059 20.1 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK51133.1 - 0.00047 20.7 0.2 0.0072 16.9 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK51133.1 - 0.0011 19.4 0.0 0.0039 17.6 0.0 2.0 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF4149 PF13664.6 PIK51133.1 - 0.043 14.1 0.1 0.16 12.3 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) CrgA PF06781.12 PIK51133.1 - 2 8.5 4.9 0.8 9.8 0.7 2.4 2 1 0 2 2 2 0 Cell division protein CrgA DUF3810 PF12725.7 PIK51133.1 - 2.7 7.3 6.8 0.35 10.2 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) SH3_2 PF07653.17 PIK51134.1 - 2.4e-12 46.3 0.0 5.4e-12 45.2 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK51134.1 - 1.4e-11 43.8 0.1 3.2e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK51134.1 - 5.6e-10 38.9 0.1 1e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain MCC-bdg_PDZ PF10506.9 PIK51135.1 - 2.2e-24 85.2 5.7 2.2e-24 85.2 5.7 5.6 8 0 0 8 8 8 1 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF4262 PF14081.6 PIK51135.1 - 1.6e-05 25.1 1.0 0.29 11.4 0.1 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF4262) FAM76 PF16046.5 PIK51135.1 - 0.00012 21.6 1.2 0.00012 21.6 1.2 4.2 3 1 1 4 4 4 2 FAM76 protein ERM PF00769.19 PIK51135.1 - 0.00014 21.8 3.4 0.00014 21.8 3.4 4.9 3 1 1 5 5 5 2 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK51135.1 - 0.017 15.6 67.3 0.075 13.6 13.1 5.6 4 2 0 5 5 5 0 Apg6 coiled-coil region Limkain-b1 PF11608.8 PIK51135.1 - 0.056 13.5 6.3 58 3.9 0.0 6.1 3 1 4 7 7 7 0 Limkain b1 DUF5614 PF18474.1 PIK51135.1 - 0.1 11.9 4.4 1.9 7.7 0.8 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5614) GAS PF13851.6 PIK51135.1 - 5.9 6.2 54.3 0.19 11.1 9.1 5.5 5 1 0 5 5 5 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK51135.1 - 6.6 5.5 53.2 0.58 9.0 10.7 4.8 4 1 0 4 4 4 0 Spc7 kinetochore protein MCC-bdg_PDZ PF10506.9 PIK51136.1 - 4.2e-08 33.1 0.9 4.2e-08 33.1 0.9 1.5 2 0 0 2 2 2 1 PDZ domain of MCC-2 bdg protein for Usher syndrome BetaGal_dom2 PF10435.9 PIK51136.1 - 0.02 14.7 0.1 0.025 14.4 0.1 1.0 1 0 0 1 1 1 0 Beta-galactosidase, domain 2 CLZ PF16526.5 PIK51136.1 - 0.24 11.8 4.9 1.1 9.7 4.2 2.0 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ALO PF04030.14 PIK51137.1 - 9.7e-16 58.4 3.8 1.6e-15 57.6 3.8 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 PIK51137.1 - 2.9e-06 27.1 0.6 0.0012 18.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain MCC-bdg_PDZ PF10506.9 PIK51138.1 - 2.1e-16 59.7 1.7 4.2e-16 58.7 1.7 1.5 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF2937 PF11157.8 PIK51138.1 - 0.02 14.6 4.1 0.024 14.3 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) DUF3800 PF12686.7 PIK51138.1 - 0.43 11.2 1.9 1.2 9.8 1.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Exonuc_VII_L PF02601.15 PIK51138.1 - 0.55 9.7 6.7 0.63 9.6 6.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 PIK51138.1 - 0.68 10.0 5.8 1.5 8.9 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HSP70 PF00012.20 PIK51139.1 - 8.1e-07 27.6 3.2 9e-07 27.5 3.2 1.0 1 0 0 1 1 1 1 Hsp70 protein HSP70 PF00012.20 PIK51140.1 - 3.1e-107 359.2 0.2 4.1e-107 358.8 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK51140.1 - 7.5e-17 61.1 0.0 1e-16 60.7 0.0 1.0 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.10 PIK51140.1 - 0.00011 21.3 0.3 0.008 15.2 0.2 2.1 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 PIK51140.1 - 0.0086 15.4 0.0 0.023 13.9 0.0 1.7 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Actin PF00022.19 PIK51140.1 - 0.022 13.4 0.0 1.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Actin FtsA PF14450.6 PIK51140.1 - 0.031 14.7 0.0 0.069 13.6 0.0 1.6 1 1 0 1 1 1 0 Cell division protein FtsA StbA PF06406.11 PIK51140.1 - 0.031 13.5 0.0 0.053 12.8 0.0 1.5 2 0 0 2 2 2 0 StbA protein MetOD2 PF18548.1 PIK51140.1 - 0.06 13.5 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Metanogen output domain 2 HSP70 PF00012.20 PIK51141.1 - 1.5e-45 155.5 0.1 1.8e-45 155.2 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.20 PIK51141.1 - 0.092 12.2 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.20 PIK51142.1 - 8.2e-07 27.6 4.7 9.3e-07 27.4 4.7 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF3813 PF12758.7 PIK51142.1 - 0.26 11.7 3.5 0.29 11.5 3.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3813) LRR_8 PF13855.6 PIK51143.1 - 1.8e-11 43.6 1.0 2.7e-11 43.1 1.0 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 PIK51143.1 - 1.3e-05 25.4 2.9 1.3e-05 25.4 2.9 1.9 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51143.1 - 0.00048 20.1 0.5 0.00076 19.4 0.1 1.5 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK51143.1 - 0.018 15.5 0.4 16 6.6 0.0 2.8 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK51143.1 - 0.048 13.7 1.6 11 6.3 0.0 2.8 2 1 1 3 3 3 0 Leucine Rich repeat DUF2958 PF11171.8 PIK51143.1 - 0.11 12.8 0.2 0.7 10.2 0.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2958) LRR_9 PF14580.6 PIK51143.1 - 0.15 11.6 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeat rve PF00665.26 PIK51144.1 - 4e-23 81.9 0.0 9.6e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK51144.1 - 4.3e-18 65.2 1.0 1.3e-17 63.7 1.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK51144.1 - 2.1e-11 43.8 0.0 4.2e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK51144.1 - 1.6e-09 37.7 0.0 2.8e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK51144.1 - 0.0017 18.5 0.6 0.004 17.3 0.6 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK51144.1 - 0.015 15.1 0.0 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MycE_N PF17843.1 PIK51144.1 - 0.061 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 MycE methyltransferase N-terminal zf-CCHC PF00098.23 PIK51145.1 - 1e-07 31.7 1.9 2.3e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK51145.1 - 0.00036 20.3 0.1 0.00036 20.3 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK51145.1 - 0.13 12.0 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK51145.1 - 0.19 11.8 0.3 0.45 10.6 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK51145.1 - 0.24 11.2 0.5 0.5 10.1 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle AA_permease_2 PF13520.6 PIK51146.1 - 3.1e-32 111.9 32.0 4.2e-32 111.5 32.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK51146.1 - 2.3e-15 56.2 28.5 3.3e-15 55.6 28.5 1.2 1 0 0 1 1 1 1 Amino acid permease Golgin_A5 PF09787.9 PIK51147.1 - 0.0047 16.4 8.9 0.0054 16.2 8.9 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 Syntaxin_2 PF14523.6 PIK51147.1 - 0.0079 16.5 1.3 0.0079 16.5 1.3 2.1 1 1 1 2 2 2 1 Syntaxin-like protein HK97-gp10_like PF04883.12 PIK51147.1 - 0.0092 16.9 1.3 0.022 15.8 0.6 1.9 1 1 1 2 2 2 1 Bacteriophage HK97-gp10, putative tail-component DUF1390 PF07150.11 PIK51147.1 - 0.012 15.4 1.5 0.013 15.2 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) DUF4200 PF13863.6 PIK51147.1 - 0.019 15.3 11.6 0.019 15.3 11.6 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.19 PIK51147.1 - 0.03 12.3 5.1 0.031 12.2 5.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ZapB PF06005.12 PIK51147.1 - 0.032 14.7 2.8 0.032 14.7 2.8 2.4 1 1 1 2 2 2 0 Cell division protein ZapB IF-2B PF01008.17 PIK51147.1 - 0.048 12.9 2.4 0.055 12.7 2.4 1.1 1 0 0 1 1 1 0 Initiation factor 2 subunit family HOOK PF05622.12 PIK51147.1 - 0.049 11.8 10.2 0.053 11.7 10.2 1.0 1 0 0 1 1 1 0 HOOK protein FUSC PF04632.12 PIK51147.1 - 0.054 12.0 0.9 0.056 12.0 0.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4162 PF13732.6 PIK51147.1 - 0.11 13.2 1.1 0.25 12.1 0.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4162) DivIC PF04977.15 PIK51147.1 - 0.11 12.2 4.6 0.085 12.6 1.2 2.2 1 1 1 2 2 2 0 Septum formation initiator Fez1 PF06818.15 PIK51147.1 - 0.12 12.8 7.1 0.15 12.5 7.1 1.2 1 0 0 1 1 1 0 Fez1 zf-C4H2 PF10146.9 PIK51147.1 - 0.12 12.7 5.9 0.2 11.9 5.9 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein Tropomyosin PF00261.20 PIK51147.1 - 0.13 11.6 14.4 0.32 10.3 14.4 1.7 1 1 0 1 1 1 0 Tropomyosin DUF812 PF05667.11 PIK51147.1 - 0.16 10.8 11.2 0.2 10.5 11.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) YabA PF06156.13 PIK51147.1 - 0.18 12.5 7.2 0.83 10.3 7.2 2.1 1 1 0 1 1 1 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 PIK51147.1 - 0.21 11.8 10.1 0.53 10.5 10.1 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HAUS6_N PF14661.6 PIK51147.1 - 0.49 9.9 5.0 0.66 9.5 5.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TSNAXIP1_N PF15739.5 PIK51147.1 - 0.55 10.6 7.5 0.11 12.9 3.0 2.1 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF1664 PF07889.12 PIK51147.1 - 0.55 10.3 4.4 0.66 10.0 3.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 PIK51147.1 - 0.87 8.8 3.5 1 8.6 3.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF2031 PF09592.10 PIK51147.1 - 0.94 8.9 7.1 1.1 8.7 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Lectin_N PF03954.14 PIK51147.1 - 1.1 9.1 5.3 0.68 9.7 3.6 1.6 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain OEP PF02321.18 PIK51147.1 - 1.2 8.9 6.6 1.6 8.5 6.6 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein Occludin_ELL PF07303.13 PIK51147.1 - 1.3 9.8 5.0 2.2 9.1 2.2 2.3 2 1 1 3 3 2 0 Occludin homology domain BRE1 PF08647.11 PIK51147.1 - 3.4 7.8 14.5 47 4.2 13.7 2.4 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF2205 PF10224.9 PIK51147.1 - 5.4 7.1 8.6 2.5 8.1 2.1 3.0 1 1 2 3 3 3 0 Short coiled-coil protein DUF1690 PF07956.11 PIK51147.1 - 5.8 7.3 10.6 5 7.6 9.0 1.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) FlaC_arch PF05377.11 PIK51147.1 - 7.5 7.0 9.4 11 6.5 1.0 2.7 2 1 1 3 3 2 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 PIK51147.1 - 8.9 6.8 11.9 17 6.0 11.6 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 PIK51147.1 - 9.7 6.5 10.9 39 4.5 6.5 3.2 1 1 1 2 2 2 0 Haemolysin XhlA ORF45 PF17620.2 PIK51148.1 - 0.1 12.7 0.3 0.15 12.1 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function 7tm_2 PF00002.24 PIK51149.1 - 1.1e-07 31.4 0.4 1.7e-07 30.8 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) MRVI1 PF05781.12 PIK51151.1 - 7.2e-29 100.9 6.8 7.2e-29 100.9 6.8 2.9 1 1 2 3 3 3 2 MRVI1 protein KASH_CCD PF14662.6 PIK51152.1 - 6.9e-16 58.6 42.0 6.9e-16 58.6 42.0 2.5 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH EF-hand_9 PF14658.6 PIK51152.1 - 1.5e-11 44.5 0.9 1.2e-10 41.5 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain TolA_bind_tri PF16331.5 PIK51152.1 - 0.016 15.3 4.6 0.016 15.3 4.6 5.2 3 2 1 4 4 4 0 TolA binding protein trimerisation EF-hand_7 PF13499.6 PIK51152.1 - 0.12 12.8 1.7 0.85 10.1 0.0 3.0 2 1 0 2 2 2 0 EF-hand domain pair YabA PF06156.13 PIK51152.1 - 4.6 7.9 45.5 1.9 9.1 8.5 4.8 2 1 2 4 4 4 0 Initiation control protein YabA DUF525 PF04379.14 PIK51153.1 - 1e-15 57.7 0.3 2.4e-15 56.5 0.0 1.8 2 0 0 2 2 2 1 ApaG domain F-box PF00646.33 PIK51153.1 - 1.9e-08 34.0 0.2 4.4e-08 32.8 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 PIK51153.1 - 4.2e-08 33.0 0.4 8.9e-08 31.9 0.4 1.6 1 0 0 1 1 1 1 F-box-like SMI1_KNR4 PF09346.10 PIK51153.1 - 7.1e-08 32.9 0.0 1.7e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) F-box_4 PF15966.5 PIK51153.1 - 0.001 19.0 0.3 0.0023 17.8 0.1 1.7 2 0 0 2 2 2 1 F-box Histone PF00125.24 PIK51154.1 - 2e-09 37.9 2.7 2e-09 37.9 2.7 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 PIK51154.1 - 0.013 16.1 5.6 0.013 16.1 5.6 2.0 2 0 0 2 2 2 0 PCNA-associated factor histone like domain CENP-T_C PF15511.6 PIK51155.1 - 4.5e-08 33.2 0.1 8.1e-08 32.3 0.0 1.5 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 PIK51155.1 - 2.3e-05 24.7 0.1 3.8e-05 24.0 0.1 1.6 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 PIK51155.1 - 8.4e-05 22.8 0.2 0.00021 21.5 0.1 1.8 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 PIK51155.1 - 0.0001 22.4 0.6 0.00019 21.6 0.1 1.7 1 1 1 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 PIK51155.1 - 0.00038 20.8 1.0 0.00071 19.9 1.0 1.6 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 PIK51155.1 - 0.0053 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 PIK51155.1 - 0.012 15.7 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit AAA_32 PF13654.6 PIK51155.1 - 0.039 12.8 0.2 4.6 5.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain HECT PF00632.25 PIK51156.1 - 5.5e-12 45.8 0.0 1.1e-11 44.8 0.0 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UIM PF02809.20 PIK51156.1 - 0.03 14.2 0.8 0.061 13.3 0.8 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4698 PF15769.5 PIK51156.1 - 1.5 7.8 3.9 2.4 7.1 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Histone PF00125.24 PIK51157.1 - 2.5e-22 79.7 0.6 3.3e-22 79.3 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK51157.1 - 8.7e-07 29.1 0.1 1.8e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 PIK51157.1 - 0.0022 18.4 0.0 0.0038 17.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 PIK51157.1 - 0.0061 16.6 0.1 0.0069 16.4 0.1 1.2 1 0 0 1 1 1 1 YscO-like protein DUF1018 PF06252.12 PIK51157.1 - 0.038 15.0 0.4 0.05 14.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Histone_H2A_C PF16211.5 PIK51158.1 - 6.9e-21 73.7 2.0 1.1e-20 73.0 2.0 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 PIK51158.1 - 3.5e-16 59.7 0.0 4.5e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK51158.1 - 5.3e-05 23.4 0.0 7.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK51159.1 - 2.2e-14 53.9 2.3 2.2e-14 53.9 2.3 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 PIK51159.1 - 0.11 13.1 12.6 0.083 13.5 10.5 1.7 1 1 1 2 2 2 0 PCNA-associated factor histone like domain DUF3849 PF12960.7 PIK51160.1 - 0.046 13.7 1.2 6.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3849) ROS_MUCR PF05443.11 PIK51161.1 - 0.18 11.8 2.2 0.9 9.6 2.2 2.3 1 1 0 1 1 1 0 ROS/MUCR transcriptional regulator protein Histone_H2A_C PF16211.5 PIK51162.1 - 5.8e-21 73.9 2.0 9.1e-21 73.3 2.0 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 PIK51162.1 - 2.9e-16 60.0 0.0 3.6e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK51162.1 - 4.2e-05 23.7 0.0 5.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK51163.1 - 2.2e-14 53.9 2.3 2.2e-14 53.9 2.3 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 PIK51163.1 - 0.11 13.1 12.6 0.083 13.5 10.5 1.7 1 1 1 2 2 2 0 PCNA-associated factor histone like domain Histone PF00125.24 PIK51164.1 - 2e-22 80.0 0.7 2.5e-22 79.6 0.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK51164.1 - 1.4e-06 28.5 1.1 2.6e-06 27.6 0.1 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 PIK51164.1 - 0.0031 18.0 0.0 0.0054 17.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 PIK51164.1 - 0.0081 16.2 0.1 0.0092 16.0 0.1 1.2 1 0 0 1 1 1 1 YscO-like protein DUF1018 PF06252.12 PIK51164.1 - 0.054 14.5 0.6 0.072 14.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) PAT1 PF09770.9 PIK51165.1 - 6.7e-22 77.6 7.2 1.5e-19 69.9 2.5 2.8 2 1 0 2 2 2 2 Topoisomerase II-associated protein PAT1 7tm_1 PF00001.21 PIK51166.1 - 3.6e-43 147.8 17.6 4.6e-43 147.4 17.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK51166.1 - 9.5e-11 41.8 20.5 9.5e-11 41.8 20.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK51166.1 - 8.3e-09 35.2 19.3 1.1e-08 34.8 19.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK51166.1 - 0.00054 19.4 21.9 0.055 12.7 21.9 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw TerC PF03741.16 PIK51166.1 - 0.016 14.9 1.9 0.016 14.9 1.9 2.5 2 0 0 2 2 2 0 Integral membrane protein TerC family SNARE PF05739.19 PIK51166.1 - 0.053 13.5 1.3 0.053 13.5 1.3 2.6 3 0 0 3 3 1 0 SNARE domain DUF2830 PF11125.8 PIK51166.1 - 0.19 11.7 2.6 0.23 11.5 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2830) TMEM208_SND2 PF05620.11 PIK51166.1 - 0.2 11.5 0.2 0.2 11.5 0.2 2.8 4 0 0 4 4 4 0 SRP-independent targeting protein 2/TMEM208 CrgA PF06781.12 PIK51166.1 - 0.39 10.8 5.2 1.4 9.1 0.1 2.9 3 0 0 3 3 3 0 Cell division protein CrgA Gaa1 PF04114.14 PIK51166.1 - 0.59 9.1 13.0 0.021 13.9 2.3 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component DUF973 PF06157.11 PIK51166.1 - 1.4 7.9 13.2 0.055 12.5 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF973) CitMHS PF03600.16 PIK51166.1 - 2 7.5 11.6 10 5.2 11.1 1.9 1 1 0 1 1 1 0 Citrate transporter Arylesterase PF01731.20 PIK51167.1 - 7.6e-07 29.2 0.0 2.1e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 PIK51167.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 PIK51168.1 - 8e-11 42.0 0.0 2e-10 40.7 0.0 1.7 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 PIK51168.1 - 0.00028 20.6 0.0 0.00051 19.7 0.0 1.5 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region T3SS_needle_F PF09392.10 PIK51168.1 - 0.032 14.4 0.2 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF BTB_3 PF16017.5 PIK51169.1 - 3.1e-18 65.8 0.0 5.7e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain PEGA PF08308.11 PIK51169.1 - 0.048 13.5 0.1 0.087 12.7 0.1 1.3 1 0 0 1 1 1 0 PEGA domain DUF3148 PF11347.8 PIK51170.1 - 2.5e-07 30.4 3.1 4.8 7.0 0.0 6.0 1 1 5 6 6 6 3 Protein of unknown function (DUF3148) Ig_6 PF18452.1 PIK51170.1 - 0.0054 16.3 0.0 1.8e+02 1.8 0.0 5.5 7 0 0 7 7 7 0 Immunoglobulin domain Secretin PF00263.21 PIK51170.1 - 0.012 15.2 0.0 41 3.8 0.0 3.7 1 1 3 4 4 4 0 Bacterial type II and III secretion system protein TNV_CP PF03898.13 PIK51170.1 - 0.014 14.6 0.1 26 4.0 0.0 3.9 1 1 4 5 5 5 0 Satellite tobacco necrosis virus coat protein DUF4884 PF16225.5 PIK51170.1 - 0.018 15.1 0.7 1.2e+02 2.8 0.0 4.7 6 0 0 6 6 6 0 Domain of unknown function (DUF4884) Aldedh PF00171.22 PIK51171.1 - 8.4e-139 463.0 0.0 1.1e-138 462.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_C12 PF01088.21 PIK51173.1 - 2.8e-49 167.7 1.6 4.2e-48 163.9 0.0 2.7 2 1 1 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 PIK51173.1 - 6e-19 67.7 2.0 6e-19 67.7 2.0 2.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases SOUL PF04832.12 PIK51174.1 - 5.3e-36 124.3 0.6 1e-25 90.9 0.2 2.1 2 0 0 2 2 2 2 SOUL heme-binding protein zinc_ribbon_6 PF14599.6 PIK51175.1 - 0.048 13.7 0.5 4.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Zinc-ribbon Peptidase_U49 PF10463.9 PIK51175.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase U49 IGR PF09597.10 PIK51175.1 - 0.15 12.1 0.9 10 6.3 0.2 2.8 3 0 0 3 3 3 0 IGR protein motif ASC PF00858.24 PIK51176.1 - 4e-44 151.3 0.8 6.2e-23 81.5 0.5 2.0 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel NACHT PF05729.12 PIK51178.1 - 1.8e-07 31.2 0.0 3.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK51178.1 - 0.00069 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK51178.1 - 0.042 13.0 0.0 0.08 12.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 PIK51178.1 - 0.063 12.5 0.0 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Pannexin_like PF12534.8 PIK51178.1 - 0.37 9.8 1.8 0.55 9.3 1.8 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 ASD2 PF08687.11 PIK51178.1 - 4 6.9 7.1 5.4 6.5 7.1 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Retrotrans_gag PF03732.17 PIK51179.1 - 3.5e-05 24.0 0.2 0.00022 21.4 0.1 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein DUF1759 PF03564.15 PIK51179.1 - 0.0051 16.8 0.0 0.0074 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) RT_RNaseH PF17917.1 PIK51180.1 - 1.2e-35 122.0 0.1 1.8e-35 121.4 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK51180.1 - 8.5e-27 93.1 0.1 1.3e-26 92.5 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK51181.1 - 2e-19 70.0 0.0 3.3e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK51181.1 - 0.00023 20.9 0.0 0.00043 20.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain NACHT PF05729.12 PIK51183.1 - 0.079 12.9 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain HLH PF00010.26 PIK51184.1 - 1.9e-17 62.9 0.3 3.5e-17 62.1 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5327 PF17261.2 PIK51184.1 - 0.027 15.2 0.0 0.046 14.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Rab_bind PF16704.5 PIK51184.1 - 0.25 11.4 0.0 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Rab binding domain EF-hand_11 PF08976.11 PIK51186.1 - 1.2e-33 116.1 8.4 2e-07 31.8 0.0 6.2 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 PIK51186.1 - 2.6e-29 98.5 5.7 0.00013 21.2 0.0 9.3 9 1 0 9 9 9 6 EF hand EF-hand_6 PF13405.6 PIK51186.1 - 9.5e-29 96.8 18.9 6.5e-05 22.6 0.0 9.3 9 0 0 9 9 9 6 EF-hand domain EF-hand_7 PF13499.6 PIK51186.1 - 1.1e-23 83.5 19.0 3e-05 24.4 0.1 6.7 6 0 0 6 6 6 5 EF-hand domain pair EF-hand_8 PF13833.6 PIK51186.1 - 1.7e-17 63.0 2.6 5.3e-05 23.0 0.1 6.9 6 2 1 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.6 PIK51186.1 - 8e-12 44.1 4.6 0.00014 21.2 0.1 5.6 6 0 0 6 6 5 3 EF hand EF-hand_9 PF14658.6 PIK51186.1 - 1.7e-08 34.6 0.2 1.8 9.0 0.0 6.1 6 0 0 6 6 6 1 EF-hand domain DUF5580 PF17743.1 PIK51186.1 - 1.2e-06 27.4 5.1 0.11 11.1 2.5 3.9 3 1 1 4 4 4 3 Family of unknown function (DUF5580) GPHH PF16905.5 PIK51186.1 - 0.0019 17.9 0.0 0.89 9.4 0.0 4.3 5 0 0 5 5 5 1 Voltage-dependent L-type calcium channel, IQ-associated DUF2666 PF10869.8 PIK51186.1 - 0.041 14.1 0.9 0.95 9.7 0.1 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF2666) RPN13_C PF16550.5 PIK51186.1 - 0.049 13.8 0.1 3.9 7.7 0.0 3.2 3 0 0 3 3 2 0 UCH-binding domain DUF4844 PF16133.5 PIK51186.1 - 0.086 13.4 1.9 5 7.7 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4844) Speriolin_C PF15059.6 PIK51186.1 - 0.14 12.3 1.4 1.2 9.3 0.8 2.5 1 1 1 2 2 2 0 Speriolin C-terminus Caleosin PF05042.13 PIK51186.1 - 0.35 10.8 2.3 38 4.2 0.1 3.8 3 1 0 4 4 3 0 Caleosin related protein EF-hand_6 PF13405.6 PIK51187.1 - 1.8e-07 30.5 4.7 0.01 15.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK51187.1 - 9.5e-05 21.7 6.0 0.063 12.9 0.9 3.4 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 PIK51187.1 - 0.00073 19.9 1.9 0.11 13.0 0.7 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_11 PF08976.11 PIK51187.1 - 0.0016 19.3 0.1 0.2 12.6 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 PIK51187.1 - 0.011 15.2 1.8 0.43 10.2 0.2 3.1 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 PIK51187.1 - 0.22 11.4 3.3 0.56 10.1 0.4 2.9 3 1 0 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK51188.1 - 1.5e-22 77.5 13.7 4.7e-06 26.1 0.2 7.5 8 0 0 8 8 8 5 EF-hand domain EF-hand_1 PF00036.32 PIK51188.1 - 3.6e-22 76.2 8.7 1.7e-05 24.1 0.3 7.3 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.6 PIK51188.1 - 6.6e-22 77.7 7.7 6.7e-05 23.3 0.1 5.6 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_11 PF08976.11 PIK51188.1 - 4.5e-19 69.2 2.5 1.4e-06 29.1 0.0 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 PIK51188.1 - 3.1e-14 51.7 6.8 0.00019 20.8 0.2 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK51188.1 - 3.7e-11 42.7 1.1 8.2e-05 22.4 0.0 5.1 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_9 PF14658.6 PIK51188.1 - 4.4e-09 36.5 0.2 3.8e-05 23.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain Dockerin_1 PF00404.18 PIK51188.1 - 0.0002 21.5 0.1 1.3 9.3 0.0 4.2 4 0 0 4 4 4 1 Dockerin type I domain DUF5580 PF17743.1 PIK51188.1 - 0.0007 18.3 1.1 1.2 7.6 0.0 3.0 2 1 0 3 3 3 2 Family of unknown function (DUF5580) RNA_pol_Rpb4 PF03874.16 PIK51188.1 - 0.019 15.3 2.3 0.41 11.0 0.3 3.0 3 0 0 3 3 3 0 RNA polymerase Rpb4 DUF4250 PF14056.6 PIK51188.1 - 0.083 12.8 0.4 27 4.8 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) AAA_assoc_C PF09821.9 PIK51188.1 - 0.16 12.5 2.6 8 7.0 0.1 4.1 4 2 0 4 4 4 0 C-terminal AAA-associated domain Sulfotransfer_1 PF00685.27 PIK51189.1 - 4.5e-49 167.3 0.3 1.5e-47 162.3 0.3 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK51189.1 - 0.038 14.4 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family C2 PF00168.30 PIK51190.1 - 2.8e-29 101.4 0.1 7e-14 52.0 0.0 2.4 2 0 0 2 2 2 2 C2 domain Miga PF10265.9 PIK51190.1 - 0.063 12.2 0.2 0.27 10.1 0.8 1.7 2 0 0 2 2 2 0 Mitoguardin Exo_endo_phos_2 PF14529.6 PIK51191.1 - 3e-08 33.5 0.1 4.1e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK51191.1 - 0.021 14.4 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 PIK51192.1 - 1e-08 35.0 0.1 1.4e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK51193.1 - 0.18 12.5 0.0 0.29 11.8 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.26 PIK51194.1 - 0.003 17.7 0.0 0.0045 17.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK51195.1 - 1e-22 80.8 0.0 1.2e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Syja_N PF02383.18 PIK51196.1 - 1e-57 195.9 1.2 1.8e-51 175.4 0.1 2.3 1 1 1 2 2 2 2 SacI homology domain PARP PF00644.20 PIK51197.1 - 4.3e-66 222.2 0.0 9.8e-66 221.1 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 PIK51197.1 - 9.5e-48 161.7 0.2 1.8e-47 160.9 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 PIK51197.1 - 1.3e-22 79.6 2.5 1.3e-22 79.6 2.5 2.2 2 0 0 2 2 2 1 WGR domain WWE PF02825.20 PIK51197.1 - 2e-18 66.7 16.1 3.5e-13 50.0 2.0 3.4 4 0 0 4 4 4 2 WWE domain ABC_export PF16962.5 PIK51198.1 - 0.017 13.6 0.5 3.8 5.9 0.0 2.7 1 1 3 4 4 4 0 Putative ABC exporter TBCC PF07986.12 PIK51198.1 - 0.25 11.1 9.0 36 4.1 0.5 4.8 1 1 4 6 6 6 0 Tubulin binding cofactor C FMN_bind PF04205.14 PIK51198.1 - 8.2 7.1 12.7 27 5.4 0.1 5.5 4 2 1 5 5 5 0 FMN-binding domain Beach PF02138.18 PIK51199.1 - 1.4e-113 378.9 0.1 2.1e-113 378.3 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 PIK51199.1 - 6e-24 83.9 21.6 0.00012 22.7 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK51199.1 - 4.5e-17 62.1 2.3 0.00061 20.0 0.0 5.7 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH PF14844.6 PIK51199.1 - 1.7e-07 31.3 0.2 0.00024 21.1 0.1 3.6 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH eIF2A PF08662.11 PIK51199.1 - 4.4e-05 23.5 0.2 0.016 15.1 0.0 3.4 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A GRAM PF02893.20 PIK51199.1 - 6.3e-05 22.8 0.2 0.0013 18.6 0.0 2.5 2 0 0 2 2 2 1 GRAM domain Frtz PF11768.8 PIK51199.1 - 0.0012 17.2 1.8 0.02 13.3 0.1 2.6 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 PIK51199.1 - 0.003 16.7 0.1 0.0063 15.6 0.1 1.5 1 0 0 1 1 1 1 Coatomer WD associated region WD40_like PF17005.5 PIK51199.1 - 0.01 15.2 0.1 0.63 9.3 0.0 2.7 1 1 2 3 3 3 0 WD40-like domain Nucleoporin_N PF08801.11 PIK51199.1 - 0.067 11.9 1.7 2.8 6.6 0.3 2.8 1 1 1 3 3 3 0 Nup133 N terminal like PH_TFIIH PF08567.11 PIK51199.1 - 0.11 12.8 0.0 32 4.9 0.0 2.8 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Scs3p PF10261.9 PIK51200.1 - 1e-18 67.7 19.3 1e-16 61.2 0.6 2.7 2 1 1 3 3 3 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 PIK51200.1 - 1.8 8.4 13.0 2.7 7.8 9.9 2.6 2 1 0 2 2 2 0 PAP2 superfamily Aminotran_1_2 PF00155.21 PIK51201.1 - 1.8e-71 241.2 0.0 2.1e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 PIK51201.1 - 3.3e-07 29.9 0.0 4.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 PIK51201.1 - 0.00024 19.8 0.0 0.00036 19.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 PIK51201.1 - 0.00055 19.0 0.0 0.0008 18.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 PIK51201.1 - 0.003 16.9 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family EF-hand_1 PF00036.32 PIK51202.1 - 4.6e-26 88.4 15.7 7.5e-07 28.3 0.2 5.6 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 PIK51202.1 - 6.6e-25 84.9 10.9 1.1e-06 28.1 0.1 5.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 PIK51202.1 - 1.8e-23 82.8 9.0 5.7e-11 42.7 0.6 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK51202.1 - 4.6e-15 54.3 14.0 2.1e-05 23.8 0.5 6.2 5 2 2 7 7 7 4 EF hand EF-hand_8 PF13833.6 PIK51202.1 - 4.4e-10 39.3 10.7 0.016 15.1 0.0 5.3 5 0 0 5 5 5 4 EF-hand domain pair Dockerin_1 PF00404.18 PIK51202.1 - 0.00013 22.1 1.8 0.28 11.4 0.2 3.3 2 2 0 2 2 2 2 Dockerin type I domain Caleosin PF05042.13 PIK51202.1 - 0.00046 20.1 1.3 2.4 8.0 0.0 3.9 3 1 0 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 PIK51202.1 - 0.0094 16.3 1.1 5.9 7.3 1.1 3.8 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 PIK51202.1 - 0.015 15.6 0.1 15 6.0 0.0 3.6 2 2 1 3 3 3 0 EF-hand domain PaaX PF07848.12 PIK51202.1 - 0.19 12.0 0.0 25 5.2 0.0 2.8 2 0 0 2 2 2 0 PaaX-like protein VASP_tetra PF08776.11 PIK51202.1 - 1.2 8.8 5.0 0.23 11.1 0.3 2.2 2 0 0 2 2 2 0 VASP tetramerisation domain Laminin_G_2 PF02210.24 PIK51203.1 - 1.1e-38 132.7 0.9 8.4e-21 74.9 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK51203.1 - 6.2e-29 100.9 0.1 1.6e-14 54.2 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 PIK51203.1 - 1.4e-07 31.7 39.8 1.5e-06 28.4 4.9 4.8 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 PIK51203.1 - 0.00032 21.2 32.8 0.00063 20.3 2.8 4.9 5 0 0 5 5 5 3 Human growth factor-like EGF Cadherin_C PF01049.17 PIK51203.1 - 0.0093 16.3 1.0 0.0093 16.3 1.0 1.6 2 0 0 2 2 2 1 Cadherin cytoplasmic region Laminin_G_3 PF13385.6 PIK51203.1 - 0.02 15.0 0.7 9.2 6.4 0.4 2.4 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily DUF3951 PF13131.6 PIK51203.1 - 0.42 10.8 2.1 0.81 9.9 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) EGF_2 PF07974.13 PIK51203.1 - 0.89 10.0 41.7 0.059 13.8 6.9 4.1 4 0 0 4 4 4 0 EGF-like domain Cadherin PF00028.17 PIK51204.1 - 1.5e-44 150.4 25.0 5.8e-10 39.5 0.2 7.3 7 0 0 7 7 7 7 Cadherin domain Cadherin PF00028.17 PIK51205.1 - 3.2e-14 53.1 0.1 4.4e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Cadherin domain Cadherin_2 PF08266.12 PIK51205.1 - 0.02 14.7 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Cadherin-like IgGFc_binding PF17517.2 PIK51206.1 - 9.6e-27 94.0 2.5 2.1e-25 89.6 2.4 2.1 2 0 0 2 2 2 2 IgGFc binding protein BRCT_2 PF16589.5 PIK51207.1 - 1.5e-13 51.0 0.0 4.1e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK51207.1 - 7.5e-07 29.4 0.0 4.2e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 PIK51207.1 - 1e-06 28.9 0.1 4e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 PIK51207.1 - 0.0027 17.6 0.0 0.0055 16.6 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 PIK51207.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain REV1_C PF16727.5 PIK51208.1 - 2.6e-09 37.4 0.1 4.9e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 PIK51208.1 - 8.3e-07 28.2 0.8 0.0015 17.9 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin binding region PCNA_N PF00705.18 PIK51208.1 - 0.11 12.3 0.4 0.24 11.1 0.4 1.5 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain Exo_endo_phos_2 PF14529.6 PIK51209.1 - 1.7e-05 24.7 0.2 7.7e-05 22.5 0.1 2.0 1 1 1 2 2 2 1 Endonuclease-reverse transcriptase DAGK_cat PF00781.24 PIK51210.1 - 2.2e-27 95.1 0.0 3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 PIK51210.1 - 5.3e-15 55.0 7.9 8.8e-15 54.3 7.9 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK51210.1 - 0.0023 18.2 1.7 0.0053 17.1 1.7 1.6 1 0 0 1 1 1 1 C1 domain zf-RING_9 PF13901.6 PIK51210.1 - 0.084 12.8 3.3 0.13 12.2 3.3 1.2 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon PHD PF00628.29 PIK51210.1 - 0.25 11.3 5.1 0.56 10.1 5.1 1.6 1 0 0 1 1 1 0 PHD-finger EF-hand_1 PF00036.32 PIK51211.1 - 3.9e-10 38.5 1.2 0.00054 19.3 0.4 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK51211.1 - 1.6e-08 34.9 0.4 2.3e-08 34.4 0.4 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK51211.1 - 1.2e-07 31.1 0.6 0.00059 19.6 0.1 2.6 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK51211.1 - 1.2e-07 30.9 0.4 0.0017 17.7 0.0 2.3 2 0 0 2 2 2 2 EF hand DAG_kinase_N PF14513.6 PIK51211.1 - 6.9e-07 29.6 0.0 9.5e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus EF-hand_8 PF13833.6 PIK51211.1 - 3.3e-06 26.8 1.2 0.0066 16.3 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK51211.1 - 0.00045 20.5 0.3 0.006 16.9 0.3 2.1 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 PIK51211.1 - 0.036 14.0 0.1 0.12 12.3 0.1 1.7 1 1 1 2 2 2 0 Caleosin related protein HTH_15 PF12324.8 PIK51211.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase EF-hand_3 PF09069.11 PIK51211.1 - 0.091 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 EF-hand EF-hand_4 PF12763.7 PIK51211.1 - 0.23 11.4 1.0 1 9.3 0.2 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DAG_kinase_N PF14513.6 PIK51212.1 - 5.4e-16 59.3 0.0 6.5e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus Oxidored_molyb PF00174.19 PIK51213.1 - 1.1e-54 184.6 0.0 1.5e-54 184.2 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain EGF_CA PF07645.15 PIK51214.1 - 8.5e-28 96.3 124.0 4.2e-10 39.7 5.9 9.7 9 1 0 9 9 9 5 Calcium-binding EGF domain cEGF PF12662.7 PIK51214.1 - 4.2e-23 80.9 65.9 3.6e-08 33.2 3.5 10.2 10 0 0 10 10 10 7 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK51214.1 - 4.3e-14 52.4 39.2 3.3e-08 33.6 12.5 8.6 8 1 1 9 9 9 4 EGF domain EGF_MSP1_1 PF12946.7 PIK51214.1 - 2.1e-10 40.5 75.5 0.00024 21.1 4.2 8.4 8 0 0 8 8 8 6 MSP1 EGF domain 1 EGF PF00008.27 PIK51214.1 - 2.3e-06 27.8 19.9 0.00018 21.7 6.0 10.3 10 2 1 11 11 11 5 EGF-like domain hEGF PF12661.7 PIK51214.1 - 0.00053 20.5 17.0 0.0013 19.3 4.9 11.1 11 1 1 12 12 12 5 Human growth factor-like EGF EGF_2 PF07974.13 PIK51214.1 - 0.022 15.1 6.1 0.022 15.1 6.1 7.6 7 1 0 7 7 7 0 EGF-like domain EGF_CA PF07645.15 PIK51215.1 - 2.5e-53 178.0 137.6 7.5e-12 45.3 7.8 10.5 9 2 1 10 10 10 7 Calcium-binding EGF domain cEGF PF12662.7 PIK51215.1 - 1e-38 130.9 84.5 7e-10 38.7 4.2 9.4 8 0 0 8 8 8 7 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK51215.1 - 2.4e-20 72.4 116.6 5.2e-06 26.5 9.7 10.0 8 2 1 9 9 9 7 EGF domain FXa_inhibition PF14670.6 PIK51215.1 - 1.6e-09 37.9 120.3 1.2e-05 25.5 8.2 9.5 6 3 2 8 8 8 6 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK51215.1 - 6.2e-08 33.0 40.5 0.00097 19.7 6.1 12.1 12 0 0 12 12 12 5 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK51215.1 - 3e-07 30.4 2.6 3e-07 30.4 2.6 9.2 9 0 0 9 9 9 4 MSP1 EGF domain 1 EGF PF00008.27 PIK51215.1 - 8.7e-07 29.1 131.7 0.0014 18.9 6.6 11.7 11 3 1 12 12 12 7 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK51215.1 - 0.0045 17.3 6.3 0.0045 17.3 6.3 8.4 6 2 2 8 8 8 4 Pvs28 EGF domain EGF_alliinase PF04863.13 PIK51216.1 - 9.6 6.7 8.2 49 4.4 7.3 2.3 2 0 0 2 2 2 0 Alliinase EGF-like domain Calx-beta PF03160.14 PIK51217.1 - 1.1e-12 47.9 32.4 0.0037 17.4 5.3 7.1 6 0 0 6 6 6 5 Calx-beta domain Sushi PF00084.20 PIK51217.1 - 2e-09 37.9 10.9 9.1e-07 29.4 0.3 4.4 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) Ldl_recept_a PF00057.18 PIK51217.1 - 1.4e-08 34.8 21.3 6.1e-07 29.6 5.4 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A NIDO PF06119.14 PIK51217.1 - 1.5e-06 29.0 4.5 1.8e-06 28.8 0.1 3.7 2 1 0 2 2 2 1 Nidogen-like EGF_CA PF07645.15 PIK51217.1 - 0.00063 19.9 0.3 0.00063 19.9 0.3 4.3 4 1 0 4 4 4 1 Calcium-binding EGF domain cEGF PF12662.7 PIK51217.1 - 0.02 14.8 12.9 0.031 14.2 3.1 3.8 3 0 0 3 3 3 0 Complement Clr-like EGF-like MH2 PF03166.14 PIK51218.1 - 2.8e-52 177.7 2.8 1.4e-49 168.9 0.1 2.2 1 1 1 2 2 2 2 MH2 domain MH1 PF03165.16 PIK51218.1 - 5.2e-27 94.1 2.4 1.1e-26 93.1 2.4 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 PIK51218.1 - 0.0089 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MH2 PF03166.14 PIK51219.1 - 1.4e-48 165.6 0.0 1.8e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 MH2 domain Lectin_C PF00059.21 PIK51220.1 - 1.4e-09 38.6 1.1 2.4e-09 37.9 1.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain SH2 PF00017.24 PIK51221.1 - 6.9e-05 22.9 0.0 0.00029 20.9 0.0 2.0 2 1 0 2 2 2 1 SH2 domain DUF724 PF05266.14 PIK51221.1 - 0.0064 16.3 0.3 0.0095 15.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) DUF4795 PF16043.5 PIK51221.1 - 0.014 15.0 1.5 0.018 14.6 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) CENP-F_leu_zip PF10473.9 PIK51221.1 - 0.019 15.0 4.0 0.034 14.2 4.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 PIK51221.1 - 0.022 15.0 0.8 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4763 PF15960.5 PIK51221.1 - 0.033 13.5 5.5 0.052 12.8 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) CobA_CobO_BtuR PF02572.15 PIK51221.1 - 0.054 13.7 0.1 0.085 13.1 0.1 1.3 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP ABC_tran_CTD PF16326.5 PIK51221.1 - 0.069 13.4 2.6 2.2 8.6 0.1 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain HSBP1 PF06825.12 PIK51221.1 - 0.079 12.8 1.5 5.7 6.9 0.0 2.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DUF2920 PF11144.8 PIK51221.1 - 0.1 11.7 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) DUF2730 PF10805.8 PIK51221.1 - 0.21 11.7 2.5 1.5 9.0 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DHR10 PF18595.1 PIK51221.1 - 0.28 11.2 4.6 3.1 7.9 0.1 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4201 PF13870.6 PIK51221.1 - 0.59 9.8 6.8 4.8 6.9 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DASH_Hsk3 PF08227.11 PIK51221.1 - 0.88 10.0 5.6 0.32 11.4 0.7 2.4 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like DUF4140 PF13600.6 PIK51221.1 - 2.2 8.8 4.8 4.9 7.7 0.6 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Csm1_N PF18504.1 PIK51221.1 - 2.7 8.4 6.3 1.8 8.9 0.3 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Pkinase_Tyr PF07714.17 PIK51222.1 - 3.3e-56 190.5 0.0 4e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51222.1 - 9.9e-34 116.9 0.0 1.2e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain B2 PF11473.8 PIK51222.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA binding protein B2 ANAPC4_WD40 PF12894.7 PIK51224.1 - 2.5e-05 24.5 0.0 0.028 14.7 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK51224.1 - 2.5e-05 24.9 3.0 0.045 14.6 0.1 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat CPSF_A PF03178.15 PIK51224.1 - 0.0073 15.7 0.0 0.0092 15.3 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region CNH PF00780.22 PIK51224.1 - 0.044 13.4 0.2 0.72 9.4 0.2 2.1 1 1 1 2 2 2 0 CNH domain CENP-K PF11802.8 PIK51225.1 - 0.031 13.9 0.1 0.047 13.3 0.1 1.2 1 0 0 1 1 1 0 Centromere-associated protein K Trp_Tyr_perm PF03222.13 PIK51226.1 - 1.1e-06 27.9 0.5 1.4e-06 27.6 0.5 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 PIK51226.1 - 7.9e-05 21.5 2.7 9.7e-05 21.2 2.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein T4_Gp59_C PF08994.10 PIK51227.1 - 0.012 16.2 0.2 0.018 15.6 0.2 1.3 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term Aa_trans PF01490.18 PIK51228.1 - 1.8e-07 30.2 1.2 2.1e-07 30.0 1.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 PIK51228.1 - 1.8e-05 23.9 1.2 2.1e-05 23.7 1.2 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Phage_holin_3_6 PF07332.11 PIK51230.1 - 0.17 12.0 4.6 0.26 11.3 4.6 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TMEM52 PF14979.6 PIK51230.1 - 5.2 7.0 8.5 1.8 8.5 3.4 2.4 2 1 0 2 2 2 0 Transmembrane 52 Gal-3-0_sulfotr PF06990.11 PIK51231.1 - 2.9e-50 171.3 0.2 3.6e-50 171.0 0.2 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK51231.1 - 8.7e-11 42.2 1.2 2.1e-10 40.9 1.2 1.7 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK51231.1 - 0.0005 19.6 0.1 0.0013 18.3 0.1 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Gal-3-0_sulfotr PF06990.11 PIK51232.1 - 3.5e-48 164.5 0.3 4.9e-48 164.0 0.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK51232.1 - 3.3e-10 40.3 2.0 1.8e-09 37.9 2.0 2.0 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK51232.1 - 0.0017 17.9 0.1 0.0053 16.3 0.1 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK51232.1 - 0.065 13.6 0.0 0.21 12.0 0.0 1.8 1 1 0 1 1 1 0 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK51233.1 - 3.1e-48 164.6 0.3 3.9e-48 164.3 0.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK51233.1 - 2.9e-08 33.9 2.7 1.6e-07 31.5 2.7 2.0 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK51233.1 - 0.00065 19.3 0.3 0.0016 18.0 0.3 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Syntaxin-6_N PF09177.11 PIK51234.1 - 0.069 13.7 4.9 0.064 13.8 2.9 1.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF2737 PF10930.8 PIK51234.1 - 0.12 11.9 0.0 0.48 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2737) DUF1664 PF07889.12 PIK51234.1 - 0.29 11.2 3.2 1.3 9.1 2.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 PIK51234.1 - 0.4 10.7 4.9 8.7 6.4 4.9 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Snapin_Pallidin PF14712.6 PIK51234.1 - 3.8 8.0 9.2 23 5.5 6.1 2.7 2 1 0 2 2 2 0 Snapin/Pallidin UCH PF00443.29 PIK51235.1 - 1.6e-49 168.8 2.0 4.5e-49 167.3 2.0 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK51235.1 - 2.4e-24 86.5 1.5 2.4e-24 86.5 1.5 2.7 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DUF2175 PF09943.9 PIK51235.1 - 0.038 14.3 0.6 0.038 14.3 0.6 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) SIR2 PF02146.17 PIK51236.1 - 3.3e-24 85.8 1.0 7.8e-18 65.0 0.4 2.5 1 1 1 2 2 2 2 Sir2 family Nod1 PF17114.5 PIK51236.1 - 0.19 11.9 0.5 0.37 10.9 0.5 1.4 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 SPACA9 PF15120.6 PIK51236.1 - 0.25 11.1 2.6 1 9.1 1.7 2.0 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 DUF922 PF06037.11 PIK51236.1 - 0.34 10.7 3.3 0.68 9.7 3.3 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) LRR_8 PF13855.6 PIK51238.1 - 1.1e-08 34.7 22.4 0.00042 20.0 0.7 3.9 3 2 2 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 PIK51238.1 - 0.21 11.1 3.1 0.37 10.3 3.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_4 PF12799.7 PIK51238.1 - 0.33 11.4 33.0 0.25 11.8 7.7 4.8 3 1 4 7 7 7 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK51239.1 - 6.4e-25 86.7 20.4 1.6e-14 53.4 5.5 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK51239.1 - 2.2e-10 40.6 10.5 5.5e-06 26.6 0.7 2.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK51239.1 - 0.00024 21.2 12.5 0.11 13.1 0.2 5.0 3 1 1 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK51239.1 - 0.0024 17.4 0.6 0.0036 16.8 0.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 PIK51239.1 - 0.0029 17.5 12.4 2.4 8.4 0.0 5.1 5 1 1 6 6 6 3 Leucine Rich repeat LRR_8 PF13855.6 PIK51240.1 - 2e-10 40.2 10.4 2.4e-10 40.0 8.6 2.0 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK51240.1 - 0.00026 21.3 12.2 0.0037 17.6 4.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51240.1 - 0.00054 19.9 0.1 0.00054 19.9 0.1 1.6 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK51240.1 - 0.035 13.6 0.7 0.053 13.0 0.7 1.3 1 0 0 1 1 1 0 Leucine-rich repeat DUF4017 PF13209.6 PIK51240.1 - 0.14 12.1 0.9 0.3 11.0 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4017) LRR_6 PF13516.6 PIK51240.1 - 0.33 11.1 5.2 0.76 10.0 0.6 2.9 2 0 0 2 2 2 0 Leucine Rich repeat LRR_1 PF00560.33 PIK51240.1 - 8.2 7.4 11.1 29 5.7 0.3 4.2 2 1 0 2 2 2 0 Leucine Rich Repeat VWC PF00093.18 PIK51241.1 - 3.4e-37 126.6 84.3 6.6e-10 39.2 14.2 4.5 4 0 0 4 4 4 4 von Willebrand factor type C domain Pacifastin_I PF05375.13 PIK51241.1 - 1.9e-05 24.3 53.2 0.22 11.3 6.2 5.2 4 0 0 4 4 4 4 Pacifastin inhibitor (LCMII) TILa PF12714.7 PIK51241.1 - 0.0028 17.5 74.9 0.12 12.3 8.3 5.5 4 2 0 4 4 4 4 TILa domain CFC PF09443.10 PIK51241.1 - 0.0081 16.0 2.3 0.0081 16.0 2.3 5.3 4 1 1 5 5 5 3 Cripto_Frl-1_Cryptic (CFC) UPF0139 PF03669.13 PIK51241.1 - 0.17 11.8 1.4 0.27 11.1 1.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) PSP94 PF05825.11 PIK51241.1 - 0.25 11.9 53.0 0.97 10.0 7.5 4.4 2 2 2 4 4 4 0 Beta-microseminoprotein (PSP-94) 7tm_1 PF00001.21 PIK51242.1 - 1.6e-23 83.3 14.4 2.1e-23 83.0 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 PIK51242.1 - 6.1e-07 28.9 13.0 8.6e-07 28.4 13.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srx PF10328.9 PIK51242.1 - 0.26 10.9 19.9 1.2 8.7 19.7 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK51243.1 - 2.2e-32 112.4 16.2 2.5e-32 112.2 16.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK51243.1 - 2.1e-08 33.9 15.0 2.7e-08 33.5 15.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK51243.1 - 9.3e-06 25.5 14.1 1.4e-05 24.9 14.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx HMGL-like PF00682.19 PIK51244.1 - 7.6e-50 169.9 0.1 8.6e-50 169.7 0.1 1.0 1 0 0 1 1 1 1 HMGL-like P5CR_dimer PF14748.6 PIK51245.1 - 6.6e-30 103.4 0.1 5.3e-16 58.8 0.0 2.4 2 0 0 2 2 2 2 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 PIK51245.1 - 5.9e-17 62.0 0.2 1.1e-16 61.2 0.2 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 PIK51245.1 - 0.0042 16.1 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase Rossmann-like PF10727.9 PIK51245.1 - 0.0073 16.2 1.8 0.011 15.6 0.7 1.8 2 0 0 2 2 2 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 PIK51245.1 - 0.071 13.1 0.3 0.2 11.6 0.3 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 7tm_1 PF00001.21 PIK51246.1 - 3.5e-24 85.5 12.7 4.1e-24 85.3 12.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK51246.1 - 4.7e-08 32.7 12.8 7e-08 32.2 12.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Nucleoporin_FG PF13634.6 PIK51247.1 - 2.8e-06 28.1 23.1 0.0028 18.4 8.1 3.7 1 1 2 3 3 3 2 Nucleoporin FG repeat region RRM_1 PF00076.22 PIK51247.1 - 0.00021 21.0 0.0 0.00051 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK51247.1 - 0.0012 18.7 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif SAC3_GANP PF03399.16 PIK51248.1 - 1.5e-14 54.1 0.3 2.1e-14 53.6 0.3 1.2 1 0 0 1 1 1 1 SAC3/GANP family DUF2827 PF10933.8 PIK51248.1 - 0.0098 14.6 0.0 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2827) LRR_8 PF13855.6 PIK51249.1 - 1.5e-31 107.9 19.6 2.7e-13 49.5 0.2 4.3 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK51249.1 - 9.5e-13 48.1 26.1 8.4e-05 22.9 0.5 5.8 3 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51249.1 - 6.6e-10 39.0 0.4 8.2e-09 35.5 0.2 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Shisa PF13908.6 PIK51249.1 - 0.00013 22.3 0.1 0.00065 20.0 0.0 2.0 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator LRR_9 PF14580.6 PIK51249.1 - 0.00016 21.2 5.8 0.29 10.6 0.6 3.3 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 PIK51249.1 - 0.002 18.4 20.9 0.76 10.6 0.0 7.8 7 2 0 7 7 6 1 Leucine Rich Repeat LRRCT PF01463.24 PIK51249.1 - 0.012 16.1 0.2 0.045 14.3 0.2 2.0 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain ASFV_J13L PF05568.11 PIK51249.1 - 0.029 14.1 0.2 0.057 13.2 0.2 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein Sigma_reg_N PF13800.6 PIK51249.1 - 0.069 13.4 0.4 1.2 9.5 0.1 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2142 PF09913.9 PIK51249.1 - 0.18 10.6 0.0 0.18 10.6 0.0 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2142) Ca_hom_mod PF14798.6 PIK51249.1 - 0.79 8.8 4.2 1.3 8.1 0.0 2.6 3 0 0 3 3 3 0 Calcium homeostasis modulator LRR_8 PF13855.6 PIK51250.1 - 4e-31 106.6 19.5 3.5e-13 49.1 0.2 4.4 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK51250.1 - 4e-12 46.1 26.4 0.00011 22.5 0.5 5.8 3 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51250.1 - 1.6e-09 37.8 0.3 1.3e-08 34.9 0.1 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Shisa PF13908.6 PIK51250.1 - 0.00013 22.2 1.7 0.00031 21.0 0.0 2.3 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator LRR_9 PF14580.6 PIK51250.1 - 0.00038 20.0 6.0 0.66 9.5 1.3 3.3 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 PIK51250.1 - 0.0026 18.1 19.4 0.97 10.2 0.0 7.8 7 2 0 7 7 6 1 Leucine Rich Repeat ASFV_J13L PF05568.11 PIK51250.1 - 0.038 13.7 0.2 0.072 12.8 0.2 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein LRRCT PF01463.24 PIK51250.1 - 0.091 13.3 0.4 0.091 13.3 0.4 2.3 2 0 0 2 2 1 0 Leucine rich repeat C-terminal domain Sigma_reg_N PF13800.6 PIK51250.1 - 0.11 12.8 0.4 1.5 9.2 0.1 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2142 PF09913.9 PIK51250.1 - 0.13 11.1 0.1 0.25 10.1 0.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) Ca_hom_mod PF14798.6 PIK51250.1 - 2.3 7.2 5.1 1.6 7.7 0.0 2.5 3 0 0 3 3 3 0 Calcium homeostasis modulator LRR_8 PF13855.6 PIK51251.1 - 6.8e-56 185.9 50.0 2.3e-14 52.9 5.2 4.8 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK51251.1 - 1.1e-21 76.5 15.8 8.9e-06 26.0 1.0 6.2 1 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51251.1 - 2.5e-19 69.5 0.0 2.6e-10 40.3 0.0 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK51251.1 - 4.9e-11 41.6 13.2 1.4 9.7 0.1 9.1 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK51251.1 - 7e-08 31.9 17.3 1.1 9.5 0.9 8.9 9 0 0 9 9 9 4 Leucine Rich repeat LRR_9 PF14580.6 PIK51251.1 - 5.6e-07 29.2 4.3 0.00012 21.6 0.6 3.1 2 1 1 3 3 3 2 Leucine-rich repeat Orf78 PF06024.12 PIK51251.1 - 0.12 12.7 0.1 0.22 11.9 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) SAC3_GANP PF03399.16 PIK51252.1 - 3.3e-26 92.3 0.6 3.3e-26 92.3 0.6 1.8 2 0 0 2 2 2 1 SAC3/GANP family MCM3AP_GANP PF16769.5 PIK51252.1 - 3e-15 55.6 2.2 2e-14 52.9 0.0 2.3 2 1 0 2 2 2 1 MCM3AP domain of GANP CSN8_PSD8_EIF3K PF10075.9 PIK51252.1 - 7e-06 26.1 1.6 5.1e-05 23.3 0.0 2.4 2 1 0 2 2 2 1 CSN8/PSMD8/EIF3K family Chrome_Resist PF09828.9 PIK51252.1 - 0.061 13.8 0.5 0.34 11.4 0.1 2.4 3 0 0 3 3 3 0 Chromate resistance exported protein MCM3AP_GANP PF16769.5 PIK51253.1 - 2.6e-12 45.9 0.0 2.8e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 MCM3AP domain of GANP MCM3AP_GANP PF16769.5 PIK51254.1 - 2.5e-29 102.1 6.1 1e-28 100.1 1.1 2.0 1 1 1 2 2 2 2 MCM3AP domain of GANP VWC PF00093.18 PIK51255.1 - 1.1e-14 54.5 33.4 1.1e-07 32.0 13.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type C domain VWC PF00093.18 PIK51256.1 - 3.6e-19 68.8 35.9 1.6e-10 41.2 15.2 2.1 2 0 0 2 2 2 2 von Willebrand factor type C domain S1FA PF04689.13 PIK51257.1 - 0.073 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 DNA binding protein S1FA Neurexophilin PF06312.12 PIK51258.1 - 1.9e-13 50.4 0.5 5.4e-13 48.9 0.5 1.7 2 0 0 2 2 2 1 Neurexophilin Filamin PF00630.19 PIK51258.1 - 0.012 16.5 0.0 0.051 14.4 0.0 1.9 2 1 0 2 2 2 0 Filamin/ABP280 repeat DUF2612 PF11041.8 PIK51258.1 - 0.2 11.5 0.5 9.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2612) Kelch_1 PF01344.25 PIK51259.1 - 9.5e-78 255.6 8.5 6.7e-17 60.8 0.5 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK51259.1 - 4.5e-50 166.4 0.2 8.6e-10 38.5 0.0 7.0 4 1 3 7 7 7 6 Kelch motif BACK PF07707.15 PIK51259.1 - 4.3e-32 110.3 1.3 8.4e-32 109.3 0.5 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 PIK51259.1 - 9.3e-30 103.1 0.3 5e-29 100.8 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 PIK51259.1 - 2.5e-29 100.1 1.7 1.9e-06 27.6 0.0 7.2 7 1 0 7 7 7 5 Kelch motif Kelch_4 PF13418.6 PIK51259.1 - 7.2e-23 80.3 0.1 0.00078 19.4 0.0 6.8 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK51259.1 - 4e-19 68.4 3.2 3.8e-05 23.9 0.2 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK51259.1 - 2e-13 50.0 4.1 0.0039 17.2 0.1 6.0 6 0 0 6 6 6 3 Kelch motif Varsurf_PPLC PF03490.13 PIK51259.1 - 0.014 15.3 0.0 5.5 7.0 0.0 2.9 2 0 0 2 2 2 0 Variant-surface-glycoprotein phospholipase C PQQ_3 PF13570.6 PIK51259.1 - 0.015 15.8 6.6 0.38 11.3 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain MoaF PF10703.9 PIK51259.1 - 0.021 14.8 0.2 1.3 9.0 0.2 2.5 2 0 0 2 2 2 0 MoaF N-terminal domain G_glu_transpept PF01019.21 PIK51260.1 - 1.8e-93 314.1 0.0 3.4e-93 313.1 0.0 1.5 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase Asp_Arg_Hydrox PF05118.15 PIK51261.1 - 7.1e-58 194.9 0.1 1.2e-57 194.1 0.1 1.4 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_14 PF13428.6 PIK51261.1 - 2.4e-12 46.6 5.2 0.35 11.8 0.0 5.8 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.6 PIK51261.1 - 1.4e-11 44.7 5.1 0.0021 18.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51261.1 - 3.5e-11 43.5 2.8 0.0037 17.9 0.3 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51261.1 - 1.5e-10 40.3 9.0 0.0079 16.2 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK51261.1 - 1e-09 37.8 2.3 0.00095 18.9 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51261.1 - 1.8e-09 37.0 1.5 0.05 13.8 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK51261.1 - 1.8e-07 31.3 2.1 8.2e-05 22.8 0.2 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK51261.1 - 2.9e-07 30.7 9.9 3.5 8.5 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK51261.1 - 6.6e-07 28.9 0.3 0.94 9.7 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat PknG_TPR PF16918.5 PIK51261.1 - 0.0046 15.7 0.1 0.0067 15.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_10 PF13374.6 PIK51261.1 - 0.0056 16.5 1.7 9.5 6.2 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51261.1 - 0.0089 16.2 3.6 1.2 9.3 0.0 3.2 3 1 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51261.1 - 0.012 15.8 0.2 2.6 8.3 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 PIK51261.1 - 0.012 15.3 2.8 0.033 13.9 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 PIK51261.1 - 0.028 14.8 0.0 93 3.8 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat PPR PF01535.20 PIK51261.1 - 0.073 13.4 0.1 27 5.3 0.1 2.9 2 0 0 2 2 2 0 PPR repeat BTAD PF03704.17 PIK51261.1 - 0.074 13.5 8.9 10 6.6 0.7 3.9 2 2 1 3 3 3 0 Bacterial transcriptional activator domain TPR_11 PF13414.6 PIK51261.1 - 0.084 12.6 3.5 47 3.8 0.3 3.9 4 0 0 4 4 4 0 TPR repeat PPR_1 PF12854.7 PIK51261.1 - 0.15 11.8 0.1 9.5 6.0 0.1 2.8 2 0 0 2 2 2 0 PPR repeat TPR_4 PF07721.14 PIK51261.1 - 0.44 11.3 3.3 76 4.4 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2614 PF11023.8 PIK51262.1 - 0.22 11.6 2.1 0.42 10.7 2.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon containing domain Ribosomal_L30 PF00327.20 PIK51263.1 - 3.3e-22 78.1 1.5 3.3e-22 78.1 1.5 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 PIK51263.1 - 1.7e-21 76.2 15.6 3.6e-21 75.2 15.6 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain DUF5061 PF16587.5 PIK51265.1 - 0.0078 16.2 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 17 kDa common-antigen outer membrane protein Octopine_DH PF02317.17 PIK51265.1 - 0.053 13.6 0.2 0.25 11.4 0.1 2.0 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Death PF00531.22 PIK51266.1 - 2.5e-13 50.0 0.0 3.2e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Death domain HRDC PF00570.23 PIK51266.1 - 0.0085 16.1 0.1 0.02 14.9 0.0 1.6 2 0 0 2 2 2 1 HRDC domain RVT_1 PF00078.27 PIK51267.1 - 4e-15 55.9 0.2 4.7e-15 55.7 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 PIK51268.1 - 1.7e-06 28.6 0.3 0.015 15.9 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK51268.1 - 0.00021 21.4 1.9 0.84 9.9 0.0 3.7 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK51268.1 - 0.00038 20.5 0.1 0.025 14.7 0.0 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK51268.1 - 0.0038 17.4 0.1 0.023 14.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK51268.1 - 0.0071 16.4 0.3 0.044 13.8 0.3 2.3 1 1 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 PIK51268.1 - 0.046 14.1 1.1 7.2 7.0 0.0 4.0 2 1 1 3 3 3 0 Immunoglobulin domain 7TM_GPCR_Srb PF02175.16 PIK51268.1 - 0.047 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srb I-set PF07679.16 PIK51268.1 - 0.095 12.8 0.1 1.7 8.8 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin I-set domain zf-C2H2_3rep PF18868.1 PIK51268.1 - 0.11 13.1 0.4 3.2 8.4 0.0 2.3 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats RasGEF PF00617.19 PIK51269.1 - 1e-31 110.5 0.1 1.1e-31 110.4 0.1 1.0 1 0 0 1 1 1 1 RasGEF domain Hemocyanin_N PF03722.14 PIK51269.1 - 0.026 15.0 0.0 0.035 14.6 0.0 1.1 1 0 0 1 1 1 0 Hemocyanin, all-alpha domain TMP_2 PF06791.13 PIK51269.1 - 0.074 12.7 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 Prophage tail length tape measure protein C1_1 PF00130.22 PIK51270.1 - 6.8e-13 48.3 9.0 1.2e-12 47.5 9.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 PIK51270.1 - 3.4e-11 41.8 3.5 1.7e-06 27.2 0.3 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK51270.1 - 4.8e-10 38.5 0.6 5.5e-06 25.9 0.3 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK51270.1 - 1.2e-09 38.5 0.0 1.9e-05 25.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK51270.1 - 2.2e-09 36.4 0.8 0.0023 17.4 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK51270.1 - 2.2e-05 24.2 2.3 0.0063 16.3 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair Cnn_1N PF07989.11 PIK51270.1 - 0.058 13.6 1.3 0.12 12.5 1.3 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Caleosin PF05042.13 PIK51270.1 - 0.1 12.6 0.3 13 5.6 0.1 2.4 1 1 1 2 2 2 0 Caleosin related protein IMS PF00817.20 PIK51271.1 - 6e-47 159.4 0.1 1.3e-46 158.3 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 PIK51271.1 - 6.7e-14 52.6 0.0 1.6e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 PIK51271.1 - 9.6e-12 44.3 2.4 2.8e-11 42.8 2.4 1.9 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 PIK51271.1 - 0.023 15.0 0.0 0.08 13.3 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif NAD_binding_6 PF08030.12 PIK51271.1 - 0.26 11.4 3.7 0.55 10.3 0.7 2.3 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Laminin_B PF00052.18 PIK51273.1 - 5.7e-78 259.4 0.1 4.5e-34 117.2 0.0 3.3 3 0 0 3 3 3 3 Laminin B (Domain IV) Ig_3 PF13927.6 PIK51273.1 - 1.1e-62 208.6 0.8 1.8e-13 50.9 0.0 5.8 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 PIK51273.1 - 4.3e-58 193.4 0.0 5.4e-12 45.6 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.25 PIK51273.1 - 1.8e-43 146.6 0.0 2.1e-08 34.2 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 PIK51273.1 - 1.4e-40 137.5 0.0 2.6e-09 37.3 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain Laminin_EGF PF00053.24 PIK51273.1 - 9.1e-38 128.2 119.4 1.9e-07 31.1 15.2 9.7 7 2 2 9 9 9 8 Laminin EGF domain V-set PF07686.17 PIK51273.1 - 2e-17 63.4 10.7 0.0026 17.9 0.0 9.2 5 5 5 10 10 10 4 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK51273.1 - 4.3e-09 35.8 0.0 0.12 12.0 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.6 PIK51274.1 - 5e-51 171.2 1.3 2.7e-11 43.9 0.1 5.1 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK51274.1 - 2.1e-43 146.3 0.0 5.2e-08 32.8 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK51274.1 - 2.3e-34 117.5 0.0 3.1e-07 30.7 0.1 5.1 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 PIK51274.1 - 5.3e-28 97.0 0.0 3.5e-06 27.1 0.0 5.5 5 1 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 PIK51274.1 - 1.2e-15 57.6 0.9 0.025 14.7 0.0 6.6 5 2 2 7 7 7 4 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK51274.1 - 7.2e-08 31.9 0.0 0.073 12.6 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK51274.1 - 7e-07 29.2 1.4 0.52 10.4 0.1 4.2 3 1 1 4 4 4 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK51274.1 - 7.3e-06 26.0 0.0 0.18 11.9 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK51274.1 - 1.7e-05 25.0 0.0 1.3 9.3 0.0 4.5 5 1 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 PIK51274.1 - 0.049 13.4 0.1 1.7 8.5 0.0 2.9 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Ig_3 PF13927.6 PIK51275.1 - 3.2e-21 75.7 0.1 3.7e-12 46.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK51275.1 - 8.9e-20 70.6 0.0 6.2e-12 45.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK51275.1 - 5e-14 52.3 0.1 7.3e-06 26.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK51275.1 - 8.4e-14 51.7 1.5 5.2e-09 36.3 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK51275.1 - 2.8e-10 40.3 1.0 0.00014 22.0 0.0 3.0 3 1 1 4 4 4 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK51275.1 - 2.3e-05 24.4 0.1 0.029 14.4 0.0 2.3 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK51275.1 - 0.00014 22.2 0.0 0.14 12.6 0.0 2.4 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.15 PIK51275.1 - 0.00015 21.4 0.1 0.068 13.0 0.0 2.5 2 0 0 2 2 2 2 Adenovirus E3 region protein CR1 Ig_6 PF18452.1 PIK51275.1 - 0.0002 20.9 0.0 0.8 9.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set PF05790.15 PIK51275.1 - 0.00094 19.3 0.1 1.7 8.9 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin C2-set domain Ig_4 PF16680.5 PIK51275.1 - 0.0025 18.0 1.5 0.46 10.8 0.1 2.7 2 1 1 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Laminin_G_2 PF02210.24 PIK51276.1 - 3.2e-20 73.0 0.0 5.6e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK51276.1 - 3.7e-18 66.0 0.0 7.7e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 PIK51276.1 - 4.9e-05 23.5 8.7 0.00011 22.4 8.7 1.7 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK51276.1 - 0.0019 18.7 2.2 0.011 16.4 2.2 2.4 1 1 0 1 1 1 1 Human growth factor-like EGF Laminin_G_3 PF13385.6 PIK51276.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 PIK51277.1 - 9.1e-44 148.8 0.0 1.3e-25 90.1 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 PIK51277.1 - 1e-39 136.0 0.0 7.1e-23 81.6 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 PIK51277.1 - 8.1e-15 54.8 15.5 1.2e-07 31.9 3.7 2.6 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 PIK51277.1 - 3.1e-06 27.6 12.3 0.0076 16.8 3.7 2.8 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK51277.1 - 0.0041 17.4 17.9 0.053 13.9 5.6 2.5 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 PIK51277.1 - 2.6 8.3 16.8 0.92 9.8 7.1 2.7 1 1 1 2 2 2 0 EGF domain Ssl1 PF04056.14 PIK51278.1 - 9.6e-63 211.5 0.1 1.3e-62 211.1 0.1 1.1 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 PIK51278.1 - 0.0026 18.4 0.0 0.005 17.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain HscB_4_cys PF18256.1 PIK51278.1 - 0.0086 15.9 1.9 0.16 11.8 0.1 2.5 2 0 0 2 2 2 1 Co-chaperone HscB tetracysteine metal binding motif DZR PF12773.7 PIK51278.1 - 0.054 13.5 7.9 0.23 11.5 6.6 2.5 1 1 1 2 2 2 0 Double zinc ribbon Peptidase_M13_N PF05649.13 PIK51279.1 - 8.3e-68 229.8 0.3 1.2e-67 229.3 0.3 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 PIK51279.1 - 2.8e-65 219.8 0.4 5.3e-65 218.9 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M13 P21-Arc PF04062.14 PIK51281.1 - 9.2e-77 257.0 0.0 1.1e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit BP28CT PF08146.12 PIK51282.1 - 0.069 13.0 0.1 0.14 12.0 0.0 1.4 2 0 0 2 2 2 0 BP28CT (NUC211) domain Fez1 PF06818.15 PIK51283.1 - 0.00013 22.5 29.7 0.00013 22.5 29.7 4.8 2 1 3 5 5 5 2 Fez1 zf-C2H2_jaz PF12171.8 PIK51283.1 - 0.023 15.0 0.2 0.074 13.4 0.2 2.0 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding TPR_MLP1_2 PF07926.12 PIK51283.1 - 6 6.9 63.6 0.52 10.4 14.0 5.4 3 1 2 5 5 5 0 TPR/MLP1/MLP2-like protein DUF2935 PF11155.8 PIK51283.1 - 7 7.0 13.4 11 6.4 0.1 4.6 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) DUF812 PF05667.11 PIK51283.1 - 10 4.9 61.0 0.014 14.3 12.5 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF812) SET PF00856.28 PIK51284.1 - 1.6e-21 77.5 0.6 1.1e-18 68.2 0.0 3.0 2 1 0 2 2 2 2 SET domain zf-C2H2 PF00096.26 PIK51285.1 - 4.9e-11 42.4 27.0 4.3e-05 23.7 4.9 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK51285.1 - 1.3e-08 34.9 10.5 7e-06 26.2 4.5 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK51285.1 - 9e-06 26.1 22.2 0.0039 17.9 4.3 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 PIK51285.1 - 0.00053 20.6 8.2 0.22 12.2 3.8 2.9 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 PIK51285.1 - 0.25 11.7 5.0 0.77 10.1 0.8 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2 PF00096.26 PIK51286.1 - 8.7e-18 63.7 25.6 3.9e-06 27.0 0.4 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK51286.1 - 6.7e-13 48.4 10.5 3.3e-08 33.6 4.3 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK51286.1 - 3.1e-10 40.0 23.3 0.00029 21.4 4.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger Ogr_Delta PF04606.12 PIK51286.1 - 0.00061 19.7 6.4 1.1 9.2 0.1 3.5 2 1 1 3 3 3 2 Ogr/Delta-like zinc finger zf-C2H2_jaz PF12171.8 PIK51286.1 - 0.0042 17.3 4.9 0.28 11.5 0.2 2.8 3 0 0 3 3 2 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 PIK51286.1 - 0.061 14.0 8.6 3.1 8.5 0.3 3.4 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 PIK51286.1 - 0.063 13.4 4.7 3.3 7.8 1.3 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2HE PF16278.5 PIK51286.1 - 0.079 13.4 4.4 5.7 7.5 1.2 2.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK51286.1 - 0.26 11.3 13.3 0.15 12.1 2.2 2.7 2 1 0 2 2 2 0 BED zinc finger zf-C2H2_8 PF15909.5 PIK51286.1 - 0.29 11.5 6.7 0.3 11.4 4.7 2.1 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.7 PIK51286.1 - 0.75 10.3 6.2 6.5 7.3 0.7 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK51286.1 - 2.8 7.8 26.7 0.59 10.0 2.3 4.6 4 2 0 4 4 4 0 C2H2-type zinc-finger domain SNF PF00209.18 PIK51287.1 - 1.1e-148 496.3 28.6 2.8e-87 293.6 12.4 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family DUF3930 PF13067.6 PIK51287.1 - 0.11 12.7 0.9 0.38 11.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3930) zf-C2H2_4 PF13894.6 PIK51288.1 - 1 10.4 11.5 0.73 10.8 3.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger SNF2_N PF00176.23 PIK51289.1 - 3.3e-46 157.6 0.3 5.1e-46 157.0 0.3 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 PIK51289.1 - 1.3e-08 35.1 0.0 4.3e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK51289.1 - 9.5e-07 29.2 0.1 0.0001 22.6 0.0 3.4 2 1 1 3 3 3 1 Helicase conserved C-terminal domain SMN PF06003.12 PIK51289.1 - 2.7e-05 23.6 0.0 2.7e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) DEAD PF00270.29 PIK51289.1 - 0.0003 20.6 0.0 0.00087 19.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase TUDOR PF00567.24 PIK51289.1 - 0.024 14.7 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Tudor domain Agenet PF05641.12 PIK51289.1 - 0.047 14.2 0.1 0.16 12.5 0.1 1.9 1 0 0 1 1 1 0 Agenet domain PBP-Tp47_a PF14889.6 PIK51289.1 - 0.75 9.4 4.4 0.51 10.0 0.1 2.9 5 0 0 5 5 5 0 Penicillin-binding protein Tp47 domain a U1snRNP70_N PF12220.8 PIK51290.1 - 4.9 7.9 8.3 0.41 11.3 2.5 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LicD PF04991.13 PIK51291.1 - 1.2e-05 25.6 1.0 0.00041 20.6 0.1 2.7 2 1 1 3 3 3 2 LicD family CI-B14_5a PF07347.12 PIK51292.1 - 5.4e-25 87.1 0.1 7.7e-25 86.6 0.1 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Cutinase PF01083.22 PIK51292.1 - 0.0023 17.9 1.8 0.0023 17.9 1.8 2.2 1 1 1 2 2 2 2 Cutinase Fibrinogen_C PF00147.18 PIK51293.1 - 3.9e-26 92.2 0.7 4.3e-26 92.1 0.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51294.1 - 5.7e-30 104.8 0.8 7.7e-30 104.3 0.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK51294.1 - 2.1e-05 24.4 7.4 2.1e-05 24.4 7.4 2.3 1 1 1 2 2 2 1 TILa domain TIL PF01826.17 PIK51294.1 - 0.0038 17.4 15.6 0.0043 17.3 2.7 2.5 2 0 0 2 2 2 2 Trypsin Inhibitor like cysteine rich domain Sulfotransfer_1 PF00685.27 PIK51295.1 - 1.9e-54 185.0 0.3 2.7e-54 184.5 0.3 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK51295.1 - 0.00061 20.2 0.1 0.0093 16.4 0.0 2.3 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK51296.1 - 1e-34 120.3 0.8 2.8e-22 79.5 0.0 3.1 2 1 0 3 3 3 2 Sulfotransferase domain LRR_8 PF13855.6 PIK51297.1 - 3.3e-30 103.6 28.2 1.5e-08 34.3 0.6 6.4 4 2 2 6 6 6 5 Leucine rich repeat LRR_5 PF13306.6 PIK51297.1 - 6.4e-18 64.9 17.9 7.3e-09 35.7 2.9 4.0 1 1 4 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK51297.1 - 4.5e-13 49.2 36.3 0.0065 16.9 0.4 7.7 5 1 2 8 8 8 6 Leucine Rich repeats (2 copies) LRRNT PF01462.18 PIK51297.1 - 8.2e-08 31.7 4.3 3.6e-07 29.7 4.3 2.2 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 PIK51297.1 - 0.017 14.6 11.0 0.85 9.1 0.2 3.9 1 1 3 4 4 4 0 Leucine-rich repeat LRR_1 PF00560.33 PIK51297.1 - 0.36 11.6 27.6 23 6.0 1.2 9.5 9 2 0 9 9 9 0 Leucine Rich Repeat PRA1 PF03208.19 PIK51298.1 - 0.019 14.6 0.3 0.019 14.6 0.3 2.0 1 1 0 1 1 1 0 PRA1 family protein RVT_1 PF00078.27 PIK51299.1 - 3.3e-25 88.9 0.0 7.8e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK51299.1 - 4.1e-20 71.6 0.2 9e-20 70.5 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK51299.1 - 1.6e-19 70.3 0.0 3.1e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK51299.1 - 5.5e-05 23.3 0.2 0.00015 21.9 0.2 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK51299.1 - 0.1 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain EGF_2 PF07974.13 PIK51301.1 - 0.021 15.2 9.9 0.021 15.2 9.9 4.3 5 0 0 5 5 5 0 EGF-like domain Laminin_EGF PF00053.24 PIK51301.1 - 0.47 10.6 27.1 0.58 10.3 15.4 3.3 1 1 2 3 3 3 0 Laminin EGF domain SDA1 PF05285.12 PIK51302.1 - 1.4 8.3 50.5 2 7.8 50.5 1.3 1 0 0 1 1 1 0 SDA1 zf-B_box PF00643.24 PIK51305.1 - 6e-15 55.1 22.6 2.7e-10 40.2 5.5 4.5 4 1 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK51305.1 - 5.3e-07 29.5 8.5 5.3e-07 29.5 8.5 4.0 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK51305.1 - 2.1e-06 27.5 9.9 2.1e-06 27.5 9.9 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK51305.1 - 1.6e-05 24.9 8.7 1.6e-05 24.9 8.7 3.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK51305.1 - 1.9e-05 24.5 9.1 1.9e-05 24.5 9.1 3.8 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK51305.1 - 0.00011 22.0 10.3 0.00011 22.0 10.3 3.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK51305.1 - 0.00035 20.8 9.0 0.00035 20.8 9.0 3.6 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 PIK51305.1 - 0.00081 19.2 7.6 0.00081 19.2 7.6 3.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 IBR PF01485.21 PIK51305.1 - 0.54 10.5 32.1 1.3 9.3 8.9 4.3 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Ephrin_rec_like PF07699.13 PIK51306.1 - 5.1e-11 42.2 5.9 5.1e-11 42.2 5.9 3.1 1 1 1 2 2 2 1 Putative ephrin-receptor like HYR PF02494.16 PIK51306.1 - 2.2e-06 27.9 4.8 4.2e-06 27.0 3.1 2.5 2 0 0 2 2 2 1 HYR domain DUF2318 PF10080.9 PIK51306.1 - 0.02 15.0 1.3 0.055 13.6 1.3 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) EGF PF00008.27 PIK51306.1 - 1.7 9.0 9.5 0.33 11.3 4.5 2.6 2 0 0 2 2 2 0 EGF-like domain DUF3730 PF12530.8 PIK51307.1 - 4.9e-44 150.6 5.5 4.9e-44 150.6 5.5 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3730) Focadhesin PF11229.8 PIK51307.1 - 1.1e-33 116.4 1.7 3.6e-33 114.7 1.7 1.8 1 1 0 1 1 1 1 Focadhesin FR47 PF08445.10 PIK51307.1 - 0.044 13.8 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein AAA_23 PF13476.6 PIK51308.1 - 2.9e-20 73.6 1.5 2.9e-20 73.6 1.5 5.3 2 2 2 4 4 4 1 AAA domain SMC_N PF02463.19 PIK51308.1 - 8.5e-19 67.9 17.6 3.3e-18 65.9 17.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK51308.1 - 1.3e-08 35.0 2.0 1.3e-08 35.0 2.0 3.6 2 2 1 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 PIK51308.1 - 4.5e-06 26.7 7.0 0.0019 18.1 0.1 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK51308.1 - 0.00095 18.9 0.0 0.0025 17.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 PIK51308.1 - 0.013 15.1 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 PIK51308.1 - 0.38 11.3 0.1 0.38 11.3 0.1 5.3 3 2 0 3 3 3 0 ABC transporter Phage_int_SAM_2 PF12834.7 PIK51308.1 - 0.55 11.0 8.0 22 5.8 0.0 4.7 4 1 0 4 4 4 0 Phage integrase, N-terminal SKA2 PF16740.5 PIK51309.1 - 0.2 11.5 2.5 0.19 11.6 0.4 1.9 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 C1_2 PF03107.16 PIK51309.1 - 0.49 10.8 10.7 1.3 9.4 3.9 2.5 2 0 0 2 2 2 0 C1 domain Y_phosphatase PF00102.27 PIK51310.1 - 4.4e-80 268.6 0.1 6.1e-80 268.2 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CRAL_TRIO PF00650.20 PIK51310.1 - 1.3e-32 112.7 0.0 2.1e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 PIK51310.1 - 3.1e-13 50.1 0.0 5.3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Y_phosphatase3 PF13350.6 PIK51310.1 - 0.0031 17.5 0.0 0.0099 15.9 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 PIK51310.1 - 0.0056 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Phage_integrase PF00589.22 PIK51311.1 - 0.0095 15.7 0.0 0.023 14.5 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family CRAL_TRIO PF00650.20 PIK51313.1 - 1.4e-41 141.9 0.0 2.5e-41 141.0 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 PIK51313.1 - 1.2e-08 34.9 0.0 2.8e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain RVT_1 PF00078.27 PIK51314.1 - 6.1e-23 81.5 0.1 7.6e-23 81.2 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chitin_synth_1 PF01644.17 PIK51316.1 - 0.046 13.7 1.7 3.2 7.7 0.3 2.7 1 1 2 3 3 3 0 Chitin synthase LRR_8 PF13855.6 PIK51317.1 - 1e-09 38.0 11.0 5e-05 23.0 0.2 4.3 5 0 0 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 PIK51317.1 - 7.9e-07 29.3 17.2 0.002 18.5 0.6 5.1 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK51317.1 - 0.00042 19.9 1.2 0.0014 18.1 0.8 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 PIK51317.1 - 0.0006 19.7 6.5 9.1 6.6 0.1 5.7 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 PIK51317.1 - 0.92 10.3 20.8 44 5.2 0.0 7.7 7 1 0 7 7 7 0 Leucine Rich Repeat IDO PF01231.18 PIK51318.1 - 0.016 14.0 0.2 0.068 12.0 0.2 1.9 1 1 0 1 1 1 0 Indoleamine 2,3-dioxygenase RadC PF04002.15 PIK51318.1 - 0.051 13.5 2.7 1.1 9.2 0.1 2.4 2 1 0 2 2 2 0 RadC-like JAB domain HNH_2 PF13391.6 PIK51318.1 - 0.79 9.9 3.3 3.4 7.9 0.3 3.1 1 1 2 3 3 3 0 HNH endonuclease EGF PF00008.27 PIK51322.1 - 1.3e-50 169.3 100.9 1.5e-08 34.8 5.9 8.3 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK51322.1 - 1.2e-33 114.6 101.2 5.4e-06 26.8 0.8 9.6 10 0 0 10 10 10 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK51322.1 - 3.1e-32 110.5 127.4 1e-05 25.6 7.9 8.1 8 0 0 8 8 8 8 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51322.1 - 4.6e-16 58.9 124.1 0.0041 17.5 10.1 8.3 8 0 0 8 8 8 8 EGF-like domain EGF_3 PF12947.7 PIK51322.1 - 2.9e-08 33.8 104.3 0.017 15.3 6.2 8.9 8 2 0 8 8 8 7 EGF domain FXa_inhibition PF14670.6 PIK51322.1 - 0.00012 22.3 88.4 0.3 11.4 5.3 8.6 3 2 5 8 8 8 4 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK51322.1 - 0.00015 21.6 86.5 0.0031 17.4 5.6 10.3 9 3 0 9 9 9 6 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK51322.1 - 0.04 14.0 100.7 0.44 10.7 4.7 8.3 3 1 5 8 8 8 0 Laminin EGF domain EGF PF00008.27 PIK51323.1 - 2.3e-58 194.0 123.4 1.6e-08 34.7 9.5 8.3 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK51323.1 - 3.9e-39 132.0 114.7 3.9e-06 27.3 4.1 9.0 8 0 0 8 8 8 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK51323.1 - 4.2e-26 90.9 136.9 4.6e-05 23.5 9.6 8.2 8 0 0 8 8 8 8 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51323.1 - 1.1e-15 57.6 147.2 0.0018 18.6 10.4 8.3 8 0 0 8 8 8 8 EGF-like domain cEGF PF12662.7 PIK51323.1 - 8.6e-07 28.8 80.7 0.011 15.7 0.4 9.5 9 0 0 9 9 9 7 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK51323.1 - 8.6e-07 29.1 100.8 0.17 12.2 7.1 8.5 4 4 4 8 8 8 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK51323.1 - 0.0087 16.2 8.2 0.0087 16.2 8.2 8.6 8 0 0 8 8 8 4 EGF domain Laminin_EGF PF00053.24 PIK51323.1 - 0.058 13.5 107.8 0.7 10.1 3.1 8.4 2 2 5 8 8 8 0 Laminin EGF domain Phage_Orf51 PF06194.11 PIK51323.1 - 0.15 12.1 0.0 16 5.6 0.0 3.6 4 0 0 4 4 4 0 Phage Conserved Open Reading Frame 51 HemY_N PF07219.13 PIK51324.1 - 0.0074 16.5 0.2 0.012 15.7 0.2 1.3 1 0 0 1 1 1 1 HemY protein N-terminus Trp_oprn_chp PF09534.10 PIK51324.1 - 0.074 12.8 0.0 0.086 12.6 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Methyltransf_11 PF08241.12 PIK51325.1 - 6.1e-11 42.8 0.0 8e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK51325.1 - 1.2e-10 41.9 0.0 1.7e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK51325.1 - 5.2e-05 23.9 0.0 0.00022 21.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK51325.1 - 0.00013 21.8 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK51325.1 - 0.0023 17.7 0.0 0.0032 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 PIK51325.1 - 0.028 14.1 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) AdoMet_MTase PF07757.13 PIK51325.1 - 0.046 14.1 0.0 0.066 13.5 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase CMAS PF02353.20 PIK51325.1 - 0.048 12.9 0.0 0.074 12.3 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 PIK51325.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 PIK51325.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Syntaxin PF00804.25 PIK51327.1 - 1.1e-05 25.2 0.7 1.1e-05 25.2 0.7 1.4 2 0 0 2 2 2 1 Syntaxin Laminin_II PF06009.12 PIK51327.1 - 0.0061 16.6 0.5 0.0074 16.3 0.5 1.1 1 0 0 1 1 1 1 Laminin Domain II FlaC_arch PF05377.11 PIK51327.1 - 0.017 15.5 2.3 0.037 14.4 2.3 1.7 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Pox_RNA_Pol_19 PF05320.12 PIK51327.1 - 0.024 14.6 3.1 0.028 14.4 3.1 1.0 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF2205 PF10224.9 PIK51327.1 - 0.041 13.9 0.6 0.056 13.4 0.4 1.4 1 1 0 1 1 1 0 Short coiled-coil protein DUF1664 PF07889.12 PIK51327.1 - 0.049 13.7 0.6 0.054 13.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CorA PF01544.18 PIK51327.1 - 0.1 11.9 0.8 0.13 11.5 0.8 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein CD225 PF04505.12 PIK51330.1 - 9.3e-06 25.7 0.5 1.6e-05 25.0 0.5 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 PIK51330.1 - 0.2 11.4 0.9 0.28 11.0 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4190) EGF PF00008.27 PIK51332.1 - 5.7e-35 119.2 111.7 9.5e-07 29.0 8.2 7.6 7 0 0 7 7 7 7 EGF-like domain EGF_2 PF07974.13 PIK51332.1 - 1.5e-23 82.9 121.9 0.00028 21.2 8.5 7.3 7 0 0 7 7 7 7 EGF-like domain hEGF PF12661.7 PIK51332.1 - 1.3e-15 57.3 112.6 0.00054 20.5 2.5 12.3 13 0 0 13 13 13 7 Human growth factor-like EGF cEGF PF12662.7 PIK51332.1 - 0.0064 16.4 1.6 0.0064 16.4 1.6 9.2 8 3 0 8 8 8 3 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK51332.1 - 0.064 13.5 127.2 0.16 12.2 8.6 8.0 4 2 3 7 7 7 0 EGF domain MFS_1 PF07690.16 PIK51333.1 - 0.0016 17.5 17.4 0.002 17.1 17.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pam17 PF08566.10 PIK51333.1 - 0.0034 17.3 0.2 0.0065 16.3 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 SEN1_N PF12726.7 PIK51333.1 - 0.12 10.5 0.0 0.16 10.1 0.0 1.1 1 0 0 1 1 1 0 SEN1 N terminal DUF2614 PF11023.8 PIK51333.1 - 0.44 10.7 2.3 0.75 9.9 2.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain FAM76 PF16046.5 PIK51334.1 - 0.33 10.2 3.1 0.46 9.8 3.1 1.1 1 0 0 1 1 1 0 FAM76 protein Glyco_transf_10 PF00852.19 PIK51335.1 - 1.1e-44 152.2 0.0 1.8e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51335.1 - 4.8e-09 36.7 0.0 8.8e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK51336.1 - 3.1e-24 85.7 0.0 3.8e-16 59.3 0.0 2.3 1 1 1 2 2 2 2 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51336.1 - 5.5e-10 39.7 0.0 1.1e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal TIMP PF00965.17 PIK51337.1 - 1.8e-19 70.3 11.1 1.5e-18 67.3 11.1 2.0 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK51337.1 - 2.1e-07 30.7 0.1 0.00022 21.0 0.0 2.3 2 0 0 2 2 2 2 UNC-6/NTR/C345C module Ephrin_rec_like PF07699.13 PIK51338.1 - 6.3e-05 22.7 20.8 0.00057 19.6 7.5 5.3 2 2 4 6 6 6 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK51338.1 - 0.0042 17.0 21.4 0.049 13.6 0.4 4.4 3 1 1 4 4 4 3 Nine Cysteines Domain of family 3 GPCR Orf78 PF06024.12 PIK51338.1 - 0.15 12.3 2.4 0.26 11.6 2.4 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Mo-nitro_C PF06967.11 PIK51339.1 - 0.0096 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Mo-dependent nitrogenase C-terminus OKR_DC_1_C PF03711.15 PIK51339.1 - 0.1 12.9 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain TMEM100 PF16311.5 PIK51339.1 - 0.16 11.6 0.1 0.2 11.3 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 100 Fibrinogen_C PF00147.18 PIK51340.1 - 5.1e-46 157.2 11.1 2.6e-44 151.7 11.1 2.2 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK51340.1 - 0.0002 21.5 4.8 0.0002 21.5 4.8 2.2 2 0 0 2 2 2 1 EGF domain EGF_MSP1_1 PF12946.7 PIK51340.1 - 0.009 16.0 2.8 0.022 14.8 2.8 1.7 1 0 0 1 1 1 1 MSP1 EGF domain 1 Tme5_EGF_like PF09064.10 PIK51340.1 - 0.05 13.5 4.0 0.16 11.9 4.0 1.9 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like TILa PF12714.7 PIK51340.1 - 0.052 13.5 3.4 0.18 11.8 3.4 2.0 1 0 0 1 1 1 0 TILa domain EGF_2 PF07974.13 PIK51340.1 - 0.74 10.2 10.2 1.4 9.4 5.3 2.9 2 0 0 2 2 2 0 EGF-like domain NACHT PF05729.12 PIK51341.1 - 2e-15 57.1 0.0 3.9e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK51341.1 - 5.5e-09 35.6 0.0 1.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain C2-set_2 PF08205.12 PIK51341.1 - 9.1e-07 28.9 2.1 2.6e-06 27.4 0.5 2.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK51341.1 - 0.00011 22.7 3.4 1.9 9.2 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin domain C1-set PF07654.15 PIK51341.1 - 0.00065 20.0 5.8 0.0074 16.6 2.1 3.9 4 0 0 4 4 4 1 Immunoglobulin C1-set domain AAA_22 PF13401.6 PIK51341.1 - 0.0041 17.4 0.0 0.031 14.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK51341.1 - 0.033 14.6 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TMEM51 PF15345.6 PIK51341.1 - 0.049 13.5 1.1 1.4 8.7 0.0 2.7 3 0 0 3 3 3 0 Transmembrane protein 51 FAM176 PF14851.6 PIK51341.1 - 0.56 9.9 5.0 0.057 13.1 0.3 1.7 2 0 0 2 2 2 0 FAM176 family DUF5301 PF17225.3 PIK51341.1 - 1.4 9.4 6.2 1.8 9.0 1.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5300) C2-set_2 PF08205.12 PIK51342.1 - 2.5e-10 40.3 0.2 3.6e-10 39.8 0.2 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK51342.1 - 1.2e-05 25.6 0.0 2.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK51342.1 - 2.5e-05 24.8 0.0 5.2e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK51342.1 - 0.00068 19.8 0.2 0.0013 18.9 0.2 1.5 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK51343.1 - 1.3e-10 41.4 0.9 5.3e-06 26.6 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain Septin PF00735.18 PIK51343.1 - 4.2e-08 32.8 0.2 2.9e-07 30.0 0.1 2.2 2 0 0 2 2 2 1 Septin Ig_3 PF13927.6 PIK51343.1 - 5.1e-08 33.4 0.4 0.048 14.3 0.0 4.0 2 1 2 4 4 4 2 Immunoglobulin domain MMR_HSR1 PF01926.23 PIK51343.1 - 1.4e-07 31.6 0.1 4e-07 30.1 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 PIK51343.1 - 4.2e-07 29.5 0.3 4.2e-07 29.5 0.3 2.3 2 1 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 PIK51343.1 - 5.7e-06 26.3 0.0 1.8e-05 24.7 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 PIK51343.1 - 6.6e-05 23.0 4.4 0.46 10.5 0.0 3.4 3 0 0 3 3 3 2 Dynamin family ig PF00047.25 PIK51343.1 - 7.4e-05 22.9 0.0 3 8.1 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin domain AAA_23 PF13476.6 PIK51343.1 - 0.0005 20.6 8.3 0.014 15.9 8.3 2.4 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 PIK51343.1 - 0.00062 19.4 0.1 0.0018 17.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 PIK51343.1 - 0.0012 18.5 0.0 0.0036 17.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SRP54 PF00448.22 PIK51343.1 - 0.0016 18.1 0.3 0.0089 15.7 0.3 2.1 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 PIK51343.1 - 0.002 17.5 0.0 0.022 14.0 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin ABC_tran PF00005.27 PIK51343.1 - 0.0022 18.5 0.1 0.015 15.8 0.0 2.4 3 0 0 3 3 3 1 ABC transporter AAA_7 PF12775.7 PIK51343.1 - 0.0056 16.2 0.1 0.018 14.5 0.1 1.9 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK51343.1 - 0.014 15.7 0.0 0.061 13.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF4245 PF14030.6 PIK51343.1 - 0.022 14.7 0.2 0.052 13.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) RNA_helicase PF00910.22 PIK51343.1 - 0.036 14.5 0.0 0.11 12.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 PIK51343.1 - 0.037 13.1 0.1 0.079 12.0 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.7 PIK51343.1 - 0.043 12.7 0.3 0.15 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA PF00004.29 PIK51343.1 - 0.044 14.2 0.1 0.78 10.2 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 PIK51343.1 - 0.044 13.8 0.0 0.097 12.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 PIK51343.1 - 0.045 14.1 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 PIK51343.1 - 0.068 12.7 0.4 8 6.0 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B ResIII PF04851.15 PIK51343.1 - 0.069 13.1 0.7 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 PIK51343.1 - 0.082 13.1 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 PIK51343.1 - 0.11 12.2 0.0 0.79 9.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MLD PF11647.8 PIK51343.1 - 0.13 12.5 0.1 0.39 11.0 0.1 1.8 1 0 0 1 1 1 0 Membrane Localization Domain AAA_30 PF13604.6 PIK51343.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Methyltransf_FA PF12248.8 PIK51345.1 - 2.1e-13 50.5 0.1 2.7e-12 46.9 0.1 2.2 1 1 1 2 2 2 1 Farnesoic acid 0-methyl transferase DUF4704 PF15787.5 PIK51345.1 - 0.025 13.8 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4704) C2 PF00168.30 PIK51346.1 - 2.7e-37 127.2 0.2 6.6e-13 48.8 0.1 3.3 3 0 0 3 3 3 3 C2 domain FerA PF08165.11 PIK51346.1 - 1.4e-15 57.0 0.3 3.4e-15 55.7 0.3 1.7 1 0 0 1 1 1 1 FerA (NUC095) domain FerB PF08150.12 PIK51346.1 - 3.2e-06 27.6 3.8 0.0007 20.1 0.4 3.3 3 0 0 3 3 3 2 FerB (NUC096) domain FerI PF08151.12 PIK51346.1 - 5.4e-06 26.4 0.0 5.4e-06 26.4 0.0 2.7 4 0 0 4 4 4 1 FerI (NUC094) domain CENP-B_dimeris PF09026.10 PIK51346.1 - 0.089 13.2 11.7 0.27 11.6 2.4 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Spt5_N PF11942.8 PIK51346.1 - 0.37 11.8 14.0 1.3 10.0 4.5 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal FAM176 PF14851.6 PIK51346.1 - 0.4 10.3 2.2 15 5.2 0.1 2.4 2 0 0 2 2 2 0 FAM176 family GEN1_C PF18380.1 PIK51346.1 - 1.2 10.1 4.6 1.7 9.6 0.5 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain YL1 PF05764.13 PIK51346.1 - 3.6 7.6 8.0 3 7.9 2.0 2.2 2 0 0 2 2 2 0 YL1 nuclear protein BSP_II PF05432.11 PIK51346.1 - 6.7 6.3 12.4 8.9 5.9 2.6 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Pex24p PF06398.11 PIK51347.1 - 0.073 12.0 3.1 0.079 11.9 3.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin C2 PF00168.30 PIK51348.1 - 2.3e-46 156.3 0.0 3.1e-16 59.5 0.0 5.3 4 1 0 4 4 4 4 C2 domain Ferlin_C PF16165.5 PIK51348.1 - 0.016 15.1 7.3 4.5 7.2 0.1 3.5 2 1 1 3 3 3 0 Ferlin C-terminus Pex24p PF06398.11 PIK51348.1 - 0.027 13.5 6.8 0.071 12.1 6.8 1.7 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin SR-25 PF10500.9 PIK51348.1 - 0.11 12.1 3.7 0.21 11.1 3.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ORC_WH_C PF18137.1 PIK51348.1 - 0.25 11.4 1.5 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Vfa1 PF08432.10 PIK51348.1 - 0.28 11.5 5.2 0.74 10.1 5.2 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NPR1_interact PF15699.5 PIK51348.1 - 3.7 8.2 9.7 0.79 10.4 5.3 2.1 2 0 0 2 2 2 0 NPR1 interacting PBP1_TM PF14812.6 PIK51348.1 - 4.7 7.7 10.7 6.7 7.2 2.4 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MFS_1 PF07690.16 PIK51349.1 - 1.3e-22 80.3 34.7 1.3e-22 80.3 34.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily ATG22 PF11700.8 PIK51349.1 - 0.0018 17.0 3.5 0.0018 17.0 3.5 2.6 2 1 0 2 2 2 1 Vacuole effluxer Atg22 like Gate PF07670.14 PIK51349.1 - 0.039 14.2 3.0 1.2 9.4 2.9 3.3 1 1 0 1 1 1 0 Nucleoside recognition OATP PF03137.20 PIK51349.1 - 0.53 8.5 6.5 0.11 10.8 2.5 1.7 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Nucleos_tra2_C PF07662.13 PIK51350.1 - 1.9e-74 250.0 3.9 1.9e-74 250.0 3.9 2.4 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 PIK51350.1 - 2.1e-23 82.7 6.9 2.1e-23 82.7 6.9 3.4 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 PIK51350.1 - 4.5e-07 30.1 10.6 4.5e-07 30.1 10.6 3.0 3 0 0 3 3 3 1 Nucleoside recognition Mtc PF03820.17 PIK51351.1 - 9.3e-129 428.9 1.0 2e-127 424.5 1.0 2.0 1 1 0 1 1 1 1 Tricarboxylate carrier RNase_T PF00929.24 PIK51352.1 - 3.5e-27 96.0 0.1 2.2e-26 93.4 0.0 2.0 2 0 0 2 2 2 1 Exonuclease HECT PF00632.25 PIK51353.1 - 2e-80 270.6 0.0 2.4e-80 270.3 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Toprim_Crpt PF13342.6 PIK51354.1 - 0.11 12.4 1.3 2.1 8.4 0.6 2.5 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase Peptidase_S8 PF00082.22 PIK51355.1 - 2.2e-38 132.2 10.2 3.1e-38 131.8 10.2 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK51355.1 - 0.0014 19.2 0.1 0.0022 18.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 RVT_1 PF00078.27 PIK51356.1 - 6.8e-40 136.9 0.1 9e-40 136.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK51357.1 - 8.8e-10 38.5 1.2 1e-09 38.2 0.2 1.7 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Nop25 PF09805.9 PIK51357.1 - 1.1 9.7 7.0 2.5 8.6 7.0 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) RIC3 PF15361.6 PIK51358.1 - 0.0077 16.6 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 USP7_C2 PF14533.6 PIK51358.1 - 0.015 15.0 0.1 0.018 14.8 0.1 1.0 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal PH_12 PF16457.5 PIK51359.1 - 0.052 14.1 20.0 1.8e+04 -9.6 20.0 5.4 1 1 0 1 1 1 0 Pleckstrin homology domain Cnd2 PF05786.14 PIK51360.1 - 2.8e-134 449.6 13.1 4.4e-134 448.9 13.1 1.2 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 PIK51360.1 - 0.0092 16.2 0.5 0.026 14.7 0.0 2.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF1081 PF06448.11 PIK51360.1 - 0.035 14.5 0.1 0.13 12.7 0.1 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1081) RVT_1 PF00078.27 PIK51361.1 - 5.4e-07 29.3 0.0 6.8e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK51362.1 - 1.1e-17 63.9 0.0 2e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK51362.1 - 2.3e-05 24.6 0.0 5.1e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK51363.1 - 7.3e-07 28.9 0.0 1.3e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IMS PF00817.20 PIK51364.1 - 7.6e-15 55.2 0.0 1.2e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family DUF1805 PF08827.11 PIK51364.1 - 0.029 14.7 0.0 0.082 13.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) IMS PF00817.20 PIK51365.1 - 1.4e-36 125.8 0.1 6.9e-36 123.5 0.1 2.2 1 1 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 PIK51365.1 - 4.8e-11 43.4 0.1 1.2e-10 42.1 0.1 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 PIK51365.1 - 1e-05 25.6 0.2 3e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 IMS family HHH motif Cdd1 PF11731.8 PIK51365.1 - 0.001 19.2 0.0 0.0031 17.7 0.0 1.8 1 0 0 1 1 1 1 Pathogenicity locus BAF PF02961.14 PIK51365.1 - 0.094 13.2 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 Barrier to autointegration factor UBM PF14377.6 PIK51365.1 - 0.24 10.9 4.1 1.2 8.7 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin binding region TraG-D_C PF12696.7 PIK51365.1 - 0.65 10.0 3.5 11 6.0 0.0 3.2 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG IMS PF00817.20 PIK51366.1 - 1.5e-32 112.6 0.1 9e-32 110.1 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 PIK51366.1 - 2.6e-07 31.3 0.0 7.4e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 PIK51366.1 - 0.00016 21.8 0.0 0.00037 20.6 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif UBM PF14377.6 PIK51366.1 - 0.0002 20.7 3.3 0.019 14.4 0.6 2.5 2 0 0 2 2 2 2 Ubiquitin binding region BAF PF02961.14 PIK51366.1 - 0.061 13.8 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Barrier to autointegration factor Acetyltransf_1 PF00583.25 PIK51367.1 - 5.8e-10 39.4 0.0 8.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK51367.1 - 2.4e-09 37.2 0.0 4.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK51367.1 - 5.6e-09 36.3 0.0 9.5e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 PIK51367.1 - 0.0021 18.1 0.0 0.0044 17.1 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 PIK51367.1 - 0.013 16.2 0.0 0.024 15.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 PIK51367.1 - 0.1 12.8 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4291 PF14124.6 PIK51367.1 - 0.18 11.6 1.5 1.1 9.0 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4291) Acetyltransf_10 PF13673.7 PIK51368.1 - 6.6e-09 35.8 0.0 1.3e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK51368.1 - 1.1e-08 35.3 0.0 1.7e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK51368.1 - 2.1e-08 34.5 0.0 3.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 PIK51368.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 PIK51368.1 - 0.012 16.2 0.0 0.025 15.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 PIK51368.1 - 0.02 15.0 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Mlo PF03094.15 PIK51368.1 - 0.083 11.2 0.3 0.12 10.7 0.3 1.1 1 0 0 1 1 1 0 Mlo family DUF4291 PF14124.6 PIK51368.1 - 0.1 12.4 0.4 0.28 11.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4291) IMS PF00817.20 PIK51369.1 - 1e-39 135.9 0.1 2.4e-39 134.7 0.1 1.7 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 PIK51369.1 - 1.4e-15 58.0 0.0 3.8e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 PIK51369.1 - 4.6e-13 49.4 0.0 1e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain REV1_C PF16727.5 PIK51369.1 - 1.3e-11 44.8 0.3 3.4e-11 43.4 0.3 1.8 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 PIK51369.1 - 1e-08 34.3 11.4 0.007 15.8 0.5 4.0 4 0 0 4 4 4 3 Ubiquitin binding region BRCT PF00533.26 PIK51369.1 - 4.6e-07 30.1 0.0 1.2e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 PIK51369.1 - 4.7e-07 30.0 0.3 1.6e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 PIK51369.1 - 7.6e-05 22.8 0.0 0.00063 19.9 0.0 2.6 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 PIK51369.1 - 0.0039 17.1 0.0 0.0098 15.8 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain BAF PF02961.14 PIK51369.1 - 0.012 16.0 0.0 0.035 14.5 0.0 1.7 1 0 0 1 1 1 0 Barrier to autointegration factor Acyltransf_C PF16076.5 PIK51369.1 - 0.063 13.4 0.4 2.8 8.1 0.0 3.0 3 0 0 3 3 3 0 Acyltransferase C-terminus RTT107_BRCT_5 PF16770.5 PIK51369.1 - 0.078 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Pox_A14 PF05767.12 PIK51370.1 - 0.0079 16.3 1.4 0.0079 16.3 1.4 3.0 4 0 0 4 4 4 1 Poxvirus virion envelope protein A14 DUF996 PF06195.13 PIK51370.1 - 0.049 13.9 16.3 0.27 11.5 1.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF996) Vut_1 PF02592.15 PIK51370.1 - 0.49 10.7 12.7 2.1 8.6 3.9 2.8 2 1 1 3 3 3 0 Putative vitamin uptake transporter Mem_trans PF03547.18 PIK51370.1 - 3.6 5.9 12.6 0.027 12.9 2.9 2.0 2 0 0 2 2 2 0 Membrane transport protein MFS_1 PF07690.16 PIK51372.1 - 7.6e-11 41.5 11.1 1e-10 41.1 11.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Claudin_2 PF13903.6 PIK51373.1 - 3.3e-10 40.0 15.6 1.3e-09 38.1 15.6 1.9 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 PIK51373.1 - 4.2e-09 36.5 12.3 1.6e-08 34.6 12.3 1.7 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 PIK51373.1 - 0.012 15.8 9.3 0.021 15.1 9.3 1.5 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 PIK51373.1 - 0.02 14.3 7.7 0.21 11.0 4.2 2.4 2 0 0 2 2 2 0 Clc-like Amastin PF07344.11 PIK51373.1 - 0.054 13.3 17.5 0.031 14.1 10.1 2.1 1 1 0 2 2 2 0 Amastin surface glycoprotein Claudin_3 PF06653.11 PIK51373.1 - 0.065 13.2 12.9 0.22 11.5 12.9 1.9 1 1 0 1 1 1 0 Tight junction protein, Claudin-like MASE3 PF17159.4 PIK51373.1 - 0.12 12.0 11.0 0.023 14.3 5.6 1.9 2 0 0 2 2 2 0 Membrane-associated sensor domain 7TMR-DISM_7TM PF07695.11 PIK51373.1 - 0.14 12.0 21.2 0.021 14.7 12.2 2.6 2 1 1 3 3 3 0 7TM diverse intracellular signalling SHR3_chaperone PF08229.11 PIK51373.1 - 3.2 6.7 9.8 0.17 10.8 4.0 1.8 2 1 0 2 2 2 0 ER membrane protein SH3 DUF872 PF05915.12 PIK51373.1 - 6.6 6.9 7.7 0.57 10.4 1.6 2.1 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Spore_YabQ PF09578.10 PIK51374.1 - 0.26 11.5 5.9 0.7 10.1 0.1 2.9 3 0 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) NSP2_assoc PF14758.6 PIK51375.1 - 0.032 14.6 0.4 0.053 13.9 0.4 1.4 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein Pkinase_Tyr PF07714.17 PIK51376.1 - 1.3e-31 109.8 0.1 1.7e-31 109.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51376.1 - 1.4e-21 77.0 0.1 2.1e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain tRNA-synt_1b PF00579.25 PIK51377.1 - 3.3e-22 79.2 0.0 7.8e-22 77.9 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Trp_dioxygenase PF03301.13 PIK51378.1 - 1.6e-87 294.1 6.0 2.3e-87 293.6 6.0 1.2 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase LRR_8 PF13855.6 PIK51381.1 - 1.7e-19 69.3 11.3 2.3e-12 46.5 2.1 4.1 3 1 1 4 4 4 2 Leucine rich repeat LRR_5 PF13306.6 PIK51381.1 - 7.2e-07 29.2 0.4 1.5e-06 28.2 0.4 1.5 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK51381.1 - 5.5e-05 23.5 17.8 0.011 16.2 4.2 4.6 2 2 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK51381.1 - 0.00029 20.4 1.0 0.0015 18.1 0.2 1.8 1 1 1 2 2 2 2 Leucine-rich repeat Shisa PF13908.6 PIK51381.1 - 0.015 15.6 0.1 0.022 15.0 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Sigma_reg_N PF13800.6 PIK51381.1 - 0.02 15.2 0.3 0.041 14.2 0.3 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMEM154 PF15102.6 PIK51381.1 - 0.047 13.6 0.1 0.082 12.8 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family Collectrin PF16959.5 PIK51381.1 - 0.052 13.3 0.9 0.12 12.2 0.9 1.5 1 0 0 1 1 1 0 Renal amino acid transporter LRR_1 PF00560.33 PIK51381.1 - 2.5 9.0 15.2 30 5.7 0.0 5.0 4 1 1 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 PIK51382.1 - 3.9e-31 106.6 30.6 1e-10 41.2 1.4 4.9 3 2 2 5 5 5 4 Leucine rich repeat LRR_5 PF13306.6 PIK51382.1 - 3e-14 53.1 4.0 2.1e-07 31.0 2.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK51382.1 - 7.8e-11 42.0 24.6 0.0099 16.3 0.5 6.1 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK51382.1 - 0.00046 19.7 9.4 0.0018 17.8 2.3 2.9 2 1 1 3 3 3 2 Leucine-rich repeat DUF5385 PF17359.2 PIK51382.1 - 0.015 14.8 0.2 0.024 14.2 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Peptidase_C1 PF00112.23 PIK51383.1 - 5.7e-58 196.6 4.9 7.4e-58 196.2 4.9 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 PIK51383.1 - 9.5e-16 57.4 0.0 1.6e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide OATP PF03137.20 PIK51384.1 - 7.6e-153 509.7 10.6 1.2e-152 509.1 10.6 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK51384.1 - 1.9e-17 63.2 24.6 1.9e-17 63.2 24.6 3.0 2 2 1 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK51384.1 - 1.3e-05 25.2 10.7 3.3e-05 23.9 10.7 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK51384.1 - 0.4 10.7 12.4 0.1 12.7 8.7 1.9 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain OATP PF03137.20 PIK51385.1 - 1.4e-148 495.6 12.5 1.8e-148 495.2 12.5 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK51385.1 - 1.7e-16 60.1 24.7 1.7e-16 60.1 24.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK51385.1 - 0.00022 21.3 13.2 0.00046 20.2 13.2 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK51385.1 - 0.027 14.5 6.9 0.078 13.0 6.9 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Peptidase_C1 PF00112.23 PIK51386.1 - 3.8e-21 76.2 3.3 1.1e-20 74.7 3.2 1.7 1 1 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 PIK51386.1 - 9.6e-16 57.4 0.1 2e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide OATP PF03137.20 PIK51387.1 - 2.8e-109 365.9 13.6 3.9e-109 365.4 13.6 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK51387.1 - 2.4e-12 46.5 28.4 3.5e-12 45.9 19.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK51387.1 - 1.4e-05 25.1 12.6 2.3e-05 24.4 12.6 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK51387.1 - 0.00029 20.8 5.1 0.00063 19.7 5.1 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain OATP PF03137.20 PIK51388.1 - 1.4e-100 337.2 7.6 1.4e-100 337.2 7.6 1.4 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK51388.1 - 2.9e-13 49.5 14.4 1.5e-08 34.0 13.8 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily zf-CCHC PF00098.23 PIK51390.1 - 0.00096 19.1 3.6 0.00096 19.1 3.6 3.3 3 0 0 3 3 3 1 Zinc knuckle DUF1133 PF06576.11 PIK51390.1 - 0.06 12.7 0.0 0.14 11.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1133) Gluconate_2-dh3 PF13618.6 PIK51390.1 - 0.19 12.0 1.1 0.32 11.2 0.5 1.6 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Ribonuclease_3 PF00636.26 PIK51390.1 - 0.8 10.4 3.2 3.8 8.2 3.2 2.2 1 1 0 1 1 1 0 Ribonuclease III domain Stathmin PF00836.19 PIK51390.1 - 0.86 9.6 10.6 0.042 13.8 4.1 2.0 2 0 0 2 2 2 0 Stathmin family Phage_lysis PF03245.13 PIK51390.1 - 4.6 7.4 9.3 0.47 10.6 3.9 2.1 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Exo_endo_phos_2 PF14529.6 PIK51391.1 - 3e-16 59.3 0.1 3e-16 59.3 0.1 2.9 3 1 0 3 3 3 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK51391.1 - 0.00099 18.7 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VWA PF00092.28 PIK51391.1 - 0.56 10.4 4.5 0.24 11.7 1.6 1.8 1 1 1 2 2 2 0 von Willebrand factor type A domain RVT_1 PF00078.27 PIK51392.1 - 2.2e-23 82.9 0.1 2.4e-23 82.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mpv17_PMP22 PF04117.12 PIK51393.1 - 7.6e-22 77.3 0.9 1.8e-21 76.1 0.9 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family Fibrinogen_C PF00147.18 PIK51394.1 - 8e-47 159.9 2.1 1.1e-46 159.5 2.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ras PF00071.22 PIK51395.1 - 4.7e-31 107.6 0.0 5.3e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK51395.1 - 1.6e-16 60.6 0.1 2.3e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK51395.1 - 2.8e-06 26.9 0.1 3.1e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK51395.1 - 0.0045 16.4 0.0 0.0051 16.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ISP1_C PF18161.1 PIK51395.1 - 0.013 15.5 0.1 0.027 14.4 0.0 1.6 2 0 0 2 2 2 0 ISP1 C-terminal ISP3_C PF18045.1 PIK51395.1 - 0.047 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 ISP3 C-terminal MMR_HSR1_Xtn PF16897.5 PIK51395.1 - 0.074 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 PIK51395.1 - 0.12 11.8 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SMN PF06003.12 PIK51396.1 - 0.13 11.5 15.9 5.6 6.1 16.0 2.3 1 1 0 1 1 1 0 Survival motor neuron protein (SMN) adh_short PF00106.25 PIK51397.1 - 1.1e-44 152.3 0.8 1.4e-44 151.9 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK51397.1 - 2.2e-32 112.5 0.1 2.9e-32 112.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK51397.1 - 2e-11 44.1 0.2 3.1e-11 43.5 0.2 1.2 1 0 0 1 1 1 1 KR domain 4F5 PF04419.14 PIK51398.1 - 3.8e-06 27.7 11.0 6.3e-06 27.0 11.0 1.4 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.7 PIK51398.1 - 0.0008 19.7 1.1 0.0021 18.4 1.1 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Spermine_synth PF01564.17 PIK51398.1 - 0.068 12.6 0.6 0.12 11.8 0.6 1.4 1 1 0 1 1 1 0 Spermine/spermidine synthase domain zf-C2H2_2 PF12756.7 PIK51398.1 - 0.078 13.3 2.7 0.49 10.7 1.7 2.4 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PLATZ PF04640.14 PIK51398.1 - 0.098 13.3 4.4 0.22 12.1 4.4 1.6 1 0 0 1 1 1 0 PLATZ transcription factor DUF4337 PF14235.6 PIK51398.1 - 0.1 12.7 2.6 3 8.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) zf-C2H2_jaz PF12171.8 PIK51398.1 - 0.11 12.8 1.3 0.26 11.6 1.3 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK51398.1 - 0.26 12.2 1.6 0.63 11.0 1.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger adh_short PF00106.25 PIK51399.1 - 1.2e-49 168.4 0.2 1.5e-49 168.1 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK51399.1 - 2.7e-41 141.6 0.1 3.4e-41 141.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK51399.1 - 2e-15 57.1 0.3 2.8e-15 56.7 0.3 1.1 1 0 0 1 1 1 1 KR domain UPF0146 PF03686.13 PIK51399.1 - 0.00069 19.5 0.1 0.0047 16.8 0.0 2.3 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0146) Epimerase PF01370.21 PIK51399.1 - 0.0015 18.0 0.5 0.0053 16.2 0.5 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK51399.1 - 0.07 13.0 0.1 0.097 12.6 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding HYR PF02494.16 PIK51400.1 - 2.9e-89 293.5 33.3 3.2e-17 62.6 2.1 8.3 8 0 0 8 8 8 8 HYR domain EGF PF00008.27 PIK51400.1 - 1.6e-08 34.7 5.0 1.6e-08 34.7 5.0 5.4 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 PIK51400.1 - 0.00021 21.8 2.2 0.00021 21.8 2.2 5.7 5 0 0 5 5 5 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK51400.1 - 0.016 15.5 8.1 0.016 15.5 8.1 4.8 4 0 0 4 4 4 0 EGF-like domain EGF PF00008.27 PIK51401.1 - 1.4e-09 38.1 2.7 1.9e-09 37.6 2.7 1.2 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK51401.1 - 8.4e-05 23.0 1.8 0.00079 20.0 1.8 2.3 1 1 0 1 1 1 1 Human growth factor-like EGF EGF_CA PF07645.15 PIK51401.1 - 0.00094 19.3 5.9 0.0015 18.7 5.9 1.5 1 1 0 1 1 1 1 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51401.1 - 0.0042 17.4 4.9 0.0095 16.3 4.9 1.6 1 1 0 1 1 1 1 EGF-like domain FXa_inhibition PF14670.6 PIK51401.1 - 0.14 12.5 5.3 0.2 11.9 5.3 1.4 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK51402.1 - 3.1e-23 81.7 40.0 7.2e-08 32.6 10.3 3.3 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK51402.1 - 4.3e-15 55.7 35.3 2.4e-05 24.8 5.7 4.1 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK51402.1 - 3.1e-07 30.6 47.0 0.00099 19.4 7.6 3.2 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 PIK51402.1 - 3.6e-05 23.9 39.6 0.067 13.4 12.4 3.3 1 1 2 3 3 3 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK51402.1 - 4.3e-05 23.7 39.4 0.029 14.7 12.1 3.6 2 2 1 3 3 3 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK51402.1 - 0.00021 21.4 34.2 0.025 14.8 9.8 3.9 2 2 1 3 3 3 2 EGF domain cEGF PF12662.7 PIK51402.1 - 0.0037 17.2 4.7 0.0037 17.2 4.7 4.2 4 1 0 4 4 4 2 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK51402.1 - 0.04 14.1 36.4 3.1 8.0 8.5 3.4 1 1 2 3 3 3 0 Laminin EGF domain EGF PF00008.27 PIK51403.1 - 9.5e-28 96.1 181.9 3e-08 33.8 5.1 13.8 15 0 0 15 15 15 9 EGF-like domain hEGF PF12661.7 PIK51403.1 - 1.2e-09 38.5 124.9 7.2e-05 23.3 4.6 13.5 13 1 0 13 13 13 9 Human growth factor-like EGF EGF_2 PF07974.13 PIK51403.1 - 0.00043 20.6 23.7 0.00077 19.8 9.3 13.5 15 1 0 15 15 15 9 EGF-like domain GBP PF02263.19 PIK51404.1 - 2.5e-55 187.5 0.0 3.2e-55 187.2 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Rhomboid PF01694.22 PIK51405.1 - 0.16 11.9 4.0 0.17 11.9 4.0 1.1 1 0 0 1 1 1 0 Rhomboid family DUF5084 PF16894.5 PIK51405.1 - 0.56 10.7 4.5 1.2 9.6 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5084) WD40 PF00400.32 PIK51406.1 - 2.7e-38 129.3 18.3 6.2e-05 23.7 0.0 11.4 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK51406.1 - 1.7e-17 63.5 0.0 2.2e-05 24.7 0.0 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK51406.1 - 9.9e-08 32.1 0.9 0.0074 16.2 0.0 3.8 4 2 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 PIK51406.1 - 4.1e-05 23.4 1.6 1.1 9.3 0.0 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 PIK51406.1 - 0.0099 15.2 0.1 1.9 7.7 0.0 3.3 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.8 PIK51406.1 - 0.037 12.7 1.4 3 6.4 0.0 3.3 2 2 1 3 3 3 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 PIK51406.1 - 0.4 11.2 2.2 1.5 9.5 0.0 3.1 3 0 0 3 3 3 0 PQQ-like domain Fibrinogen_C PF00147.18 PIK51407.1 - 7.5e-57 192.7 8.6 8.3e-57 192.5 8.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK51407.1 - 0.02 14.2 0.1 0.024 14.0 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain RT_RNaseH PF17917.1 PIK51409.1 - 2.8e-31 107.9 0.0 5e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK51409.1 - 5.1e-28 97.0 0.0 1e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK51409.1 - 7.4e-10 38.8 0.3 1.3e-09 38.0 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain SOCS_box PF07525.16 PIK51409.1 - 0.035 14.5 0.6 12 6.4 0.0 2.6 2 0 0 2 2 2 0 SOCS box Flu_PB2 PF00604.17 PIK51410.1 - 0.061 11.2 0.0 0.085 10.8 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 Saf_2TM PF18303.1 PIK51411.1 - 0.007 16.0 0.0 0.0094 15.6 0.0 1.2 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain TMIE PF16038.5 PIK51411.1 - 0.024 14.5 0.2 0.061 13.2 0.2 1.6 1 0 0 1 1 1 0 TMIE protein THEG4 PF15834.5 PIK51411.1 - 0.16 11.9 0.5 0.3 11.1 0.1 1.6 2 0 0 2 2 2 0 Testis highly expressed protein 4 LRRC37AB_C PF14914.6 PIK51412.1 - 0.041 13.8 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF3899 PF13038.6 PIK51412.1 - 0.43 11.1 0.0 0.43 11.1 0.0 2.6 3 2 0 3 3 3 0 Domain of unknown function (DUF3899) LMBR1 PF04791.16 PIK51413.1 - 4.8e-19 68.7 0.2 5.7e-17 61.8 0.0 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein TssO PF17561.2 PIK51413.1 - 0.49 10.5 0.0 0.49 10.5 0.0 3.0 3 1 0 3 3 3 0 Type VI secretion system, TssO DUF2207 PF09972.9 PIK51413.1 - 0.57 8.9 6.4 31 3.2 6.4 2.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Ribosomal_L27A PF00828.19 PIK51414.1 - 0.042 14.5 0.0 0.059 14.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A C2 PF00168.30 PIK51416.1 - 0.0042 17.4 0.0 0.0078 16.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain YfdX PF10938.8 PIK51416.1 - 0.021 14.8 0.0 0.055 13.4 0.0 1.7 1 0 0 1 1 1 0 YfdX protein NAM-associated PF14303.6 PIK51416.1 - 0.16 12.7 0.1 0.16 12.7 0.1 2.3 3 1 0 3 3 3 0 No apical meristem-associated C-terminal domain DUF3573 PF12097.8 PIK51416.1 - 0.27 10.0 0.3 0.41 9.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Pup_ligase PF03136.15 PIK51417.1 - 0.087 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Pup-ligase protein DUF2791 PF10923.8 PIK51417.1 - 0.14 11.0 0.1 0.38 9.5 0.0 1.7 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) bVLRF1 PF18826.1 PIK51417.1 - 0.2 11.5 0.7 2.4 8.0 0.4 2.6 2 0 0 2 2 2 0 bacteroidetes VLRF1 release factor I_LWEQ PF01608.17 PIK51418.1 - 1.3e-38 132.7 77.1 2.9e-33 115.3 12.2 6.7 1 1 5 7 7 7 5 I/LWEQ domain VBS PF08913.10 PIK51418.1 - 8.4e-25 87.6 4.7 8.4e-25 87.6 4.7 5.5 4 2 3 7 7 7 2 Vinculin Binding Site Herpes_ICP4_N PF03584.15 PIK51418.1 - 0.039 13.8 0.2 0.097 12.5 0.2 1.6 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region UvrD-helicase PF00580.21 PIK51419.1 - 0.0026 17.4 0.0 0.0082 15.7 0.0 1.9 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 PIK51419.1 - 0.013 15.8 0.1 0.047 14.0 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK51419.1 - 0.1 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Methyltransf_31 PF13847.6 PIK51420.1 - 0.00012 21.9 0.0 0.00015 21.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 PIK51420.1 - 0.0089 15.6 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 PIK51420.1 - 0.024 14.0 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 PIK51420.1 - 0.032 15.0 0.0 0.1 13.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 PIK51420.1 - 0.04 13.2 0.0 0.052 12.8 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 PIK51420.1 - 0.057 12.9 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 Histone methylation protein DOT1 N2227 PF07942.12 PIK51420.1 - 0.065 12.4 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein Methyltransf_25 PF13649.6 PIK51420.1 - 0.098 13.4 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Flavi_DEAD PF07652.14 PIK51420.1 - 0.17 11.9 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Flavivirus DEAD domain zf-B_box PF00643.24 PIK51421.1 - 1.8e-11 44.0 19.9 3.8e-09 36.5 5.2 4.0 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4 PF00097.25 PIK51421.1 - 4.4e-09 36.1 7.7 4.4e-09 36.1 7.7 4.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK51421.1 - 4.5e-09 36.2 6.7 4.5e-09 36.2 6.7 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK51421.1 - 6.4e-08 32.3 4.7 6.4e-08 32.3 4.7 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK51421.1 - 1.3e-07 31.3 8.4 1.3e-07 31.3 8.4 4.4 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK51421.1 - 2.6e-07 30.5 7.1 2.6e-07 30.5 7.1 4.3 3 1 1 4 4 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK51421.1 - 2.6e-07 30.7 9.8 2.6e-07 30.7 9.8 4.2 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK51421.1 - 3.6e-07 30.4 7.2 3.6e-07 30.4 7.2 3.7 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 PIK51421.1 - 8.1e-05 22.4 6.2 8.1e-05 22.4 6.2 3.7 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 DUF4637 PF15470.6 PIK51421.1 - 0.01 15.5 2.7 0.01 15.5 2.7 2.9 3 1 1 4 4 3 0 Domain of unknown function (DUF4637) IBR PF01485.21 PIK51421.1 - 0.012 15.9 2.6 0.012 15.9 2.6 5.0 4 1 1 5 5 4 0 IBR domain, a half RING-finger domain TERB2 PF15101.6 PIK51421.1 - 0.31 11.1 0.1 0.31 11.1 0.1 2.1 1 1 1 2 2 2 0 Telomere-associated protein TERB2 FYVE PF01363.21 PIK51421.1 - 5 7.4 26.2 16 5.7 4.2 4.0 1 1 2 3 3 3 0 FYVE zinc finger KH_1 PF00013.29 PIK51422.1 - 7.2e-07 29.0 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 KH domain Bromodomain PF00439.25 PIK51423.1 - 4.9e-19 68.2 0.3 1.1e-18 67.1 0.3 1.6 1 0 0 1 1 1 1 Bromodomain AAA PF00004.29 PIK51424.1 - 2.1e-06 28.2 0.0 4.9e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) zf-H2C2_2 PF13465.6 PIK51425.1 - 5.3e-44 146.8 98.4 4.3e-07 30.1 1.1 12.5 13 0 0 13 13 12 9 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK51425.1 - 2.9e-22 77.4 92.7 0.00047 20.8 2.4 12.4 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK51425.1 - 3.9e-18 64.8 98.2 0.00066 20.0 2.6 12.1 13 0 0 13 13 13 10 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK51425.1 - 1.5e-08 34.7 65.1 0.00029 21.0 0.7 11.6 12 1 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK51425.1 - 3.2e-05 24.1 60.7 0.0016 18.7 2.7 7.7 4 3 3 8 8 8 3 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK51425.1 - 0.00013 21.6 1.3 0.00013 21.6 1.3 10.1 10 2 0 10 10 10 2 C2H2-type zinc-finger domain zf-met2 PF12907.7 PIK51425.1 - 0.0098 16.0 0.1 0.0098 16.0 0.1 7.0 8 0 0 8 8 8 1 Zinc-binding PyrI_C PF02748.15 PIK51425.1 - 0.015 15.2 34.5 0.84 9.6 0.2 8.0 9 0 0 9 9 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.6 PIK51425.1 - 0.019 14.9 0.5 0.019 14.9 0.5 9.9 12 0 0 12 12 12 0 zinc-finger of a C2HC-type zf_Hakai PF18408.1 PIK51425.1 - 0.099 12.4 0.1 0.099 12.4 0.1 4.7 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain Fer2_2 PF01799.20 PIK51425.1 - 0.34 11.0 0.0 0.34 11.0 0.0 4.8 3 2 3 6 6 6 0 [2Fe-2S] binding domain GAGA PF09237.11 PIK51425.1 - 2.3 8.1 16.1 2.2 8.2 0.0 5.1 4 2 3 7 7 7 0 GAGA factor Phosducin PF02114.16 PIK51426.1 - 7.3e-68 228.4 2.0 3.4e-67 226.2 2.0 1.8 1 1 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 PIK51426.1 - 2.8e-05 24.0 0.1 5.3e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin DUF4142 PF13628.6 PIK51426.1 - 0.23 11.7 2.1 0.38 11.0 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) Hydrolase_6 PF13344.6 PIK51427.1 - 1.7e-20 73.0 0.0 3.7e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK51427.1 - 3.9e-06 26.8 0.0 0.015 15.4 0.0 2.6 2 0 0 2 2 2 2 HAD-hyrolase-like Hydrolase PF00702.26 PIK51427.1 - 0.11 12.7 0.0 0.59 10.4 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RtcB PF01139.17 PIK51428.1 - 5.5e-36 124.6 0.1 6e-36 124.5 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB RtcB PF01139.17 PIK51429.1 - 5.4e-99 332.2 0.3 6.5e-99 331.9 0.3 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB TSP_1 PF00090.19 PIK51430.1 - 7.3e-26 90.1 122.5 4.9e-07 29.9 10.9 9.6 11 0 0 11 11 11 6 Thrombospondin type 1 domain Reprolysin PF01421.19 PIK51430.1 - 3.6e-25 89.1 0.0 3.6e-25 89.1 0.0 2.6 4 0 0 4 4 4 1 Reprolysin (M12B) family zinc metalloprotease ADAM_spacer1 PF05986.14 PIK51430.1 - 1.5e-22 79.8 0.2 2.6e-22 79.0 0.2 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 PIK51430.1 - 5.1e-18 65.4 19.1 4.1e-17 62.5 6.7 6.9 4 1 2 6 6 6 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 PIK51430.1 - 9.2e-16 58.6 0.2 3.9e-15 56.5 0.2 2.1 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK51430.1 - 4.9e-12 46.5 0.0 1.2e-11 45.2 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK51430.1 - 7.5e-10 39.0 0.0 2.2e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK51430.1 - 1.3e-05 25.0 0.0 3.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 PIK51430.1 - 0.13 11.2 0.8 0.31 9.9 0.8 1.6 1 0 0 1 1 1 0 Peptidase M66 Med11 PF10280.9 PIK51430.1 - 0.17 12.3 0.1 0.3 11.5 0.1 1.3 1 0 0 1 1 1 0 Mediator complex protein 7tm_2 PF00002.24 PIK51431.1 - 2e-22 79.7 4.8 3.3e-22 79.0 4.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK51431.1 - 1.7e-09 38.1 2.2 4.2e-09 36.8 0.6 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 PIK51431.1 - 0.0044 17.3 1.6 0.0083 16.4 0.9 1.9 2 0 0 2 2 2 1 Hormone receptor domain Dicty_CAR PF05462.11 PIK51431.1 - 0.0082 15.3 2.7 0.013 14.7 2.7 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Ig_2 PF13895.6 PIK51431.1 - 0.019 15.3 0.0 0.048 14.0 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain COesterase PF00135.28 PIK51433.1 - 4.3e-72 243.6 0.0 6.4e-72 243.1 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK51433.1 - 7.1e-07 29.3 0.1 1.1e-05 25.3 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK51433.1 - 0.0036 16.8 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1776 PF08643.10 PIK51434.1 - 0.072 12.4 0.0 0.09 12.1 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) adh_short PF00106.25 PIK51435.1 - 3.9e-10 39.5 0.0 5.5e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK51435.1 - 8.1e-05 22.3 0.3 0.00013 21.6 0.1 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK51435.1 - 0.004 17.1 0.0 0.0052 16.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Gamma_PGA_hydro PF05908.11 PIK51435.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase DUF393 PF04134.12 PIK51436.1 - 3.1e-21 76.8 0.0 4.1e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF393 TraF PF13728.6 PIK51436.1 - 0.014 15.2 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Redoxin PF08534.10 PIK51436.1 - 0.091 12.5 0.1 0.15 11.7 0.1 1.3 1 1 0 1 1 1 0 Redoxin I-set PF07679.16 PIK51437.1 - 9.3e-55 182.7 0.0 1.1e-22 79.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain LRR_8 PF13855.6 PIK51437.1 - 2.3e-47 158.6 26.3 1.4e-13 50.3 1.9 5.5 2 1 3 5 5 5 5 Leucine rich repeat Ig_3 PF13927.6 PIK51437.1 - 2e-45 153.3 0.0 4.9e-15 55.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK51437.1 - 1.2e-32 112.0 0.0 1.5e-10 41.3 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK51437.1 - 9.8e-29 99.4 0.0 1.1e-10 41.5 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 PIK51437.1 - 9.1e-23 80.0 28.0 7.8e-07 29.3 1.4 6.7 2 2 6 9 9 9 9 Leucine Rich repeats (2 copies) V-set PF07686.17 PIK51437.1 - 1e-14 54.6 2.7 0.002 18.3 0.0 6.1 3 3 0 3 3 3 3 Immunoglobulin V-set domain LRR_5 PF13306.6 PIK51437.1 - 4.3e-14 52.6 0.0 2.4e-06 27.5 0.0 3.4 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK51437.1 - 1.7e-10 40.7 10.9 0.00034 20.2 0.5 4.3 1 1 4 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 PIK51437.1 - 5.7e-08 32.3 21.5 4.9 8.1 0.0 9.9 10 0 0 10 10 10 2 Leucine Rich Repeat C2-set_2 PF08205.12 PIK51437.1 - 2.7e-07 30.5 0.0 0.012 15.7 0.0 3.6 3 1 0 3 3 3 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK51437.1 - 5.5e-06 26.7 0.0 0.097 13.1 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_5 PF16681.5 PIK51437.1 - 1.8e-05 25.0 0.0 1.6 9.2 0.0 4.2 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK51437.1 - 0.00045 20.2 0.0 2 8.5 0.0 3.6 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK51437.1 - 0.001 18.6 0.0 0.24 11.0 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK51437.1 - 0.001 19.0 0.0 0.27 11.3 0.0 3.1 3 0 0 3 3 3 1 C17orf99 Ig domain V-set_CD47 PF08204.11 PIK51437.1 - 0.0068 16.4 0.1 0.85 9.6 0.0 3.2 3 1 0 3 3 3 1 CD47 immunoglobulin-like domain LRR_6 PF13516.6 PIK51437.1 - 0.025 14.6 31.1 0.73 10.0 0.1 8.3 8 0 0 8 8 8 0 Leucine Rich repeat DUF1206 PF06724.11 PIK51438.1 - 0.063 13.4 4.2 0.13 12.3 0.1 2.9 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1206) Phage_holin_3_7 PF05449.11 PIK51438.1 - 1.4 8.9 6.2 0.26 11.3 1.1 2.5 3 1 0 3 3 3 0 Putative 3TM holin, Phage_holin_3 Somatomedin_B PF01033.17 PIK51439.1 - 0.006 17.0 14.2 0.039 14.4 14.2 2.6 1 0 0 1 1 1 1 Somatomedin B domain Peptidase_C3 PF00548.20 PIK51439.1 - 0.11 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) 7tm_2 PF00002.24 PIK51440.1 - 2e-15 56.8 21.2 2.4e-15 56.5 21.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Vezatin PF12632.7 PIK51441.1 - 3.4e-08 33.2 0.1 7.8e-08 32.0 0.0 1.5 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes Podoplanin PF05808.11 PIK51442.1 - 0.78 9.8 7.5 2.2 8.4 7.5 1.8 1 0 0 1 1 1 0 Podoplanin Peptidase_S49_N PF08496.10 PIK51442.1 - 8.8 6.4 7.5 27 4.8 7.5 1.9 1 0 0 1 1 1 0 Peptidase family S49 N-terminal rve PF00665.26 PIK51443.1 - 0.058 13.6 0.0 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain Sulfotransfer_1 PF00685.27 PIK51444.1 - 9e-27 94.2 0.0 1.8e-26 93.2 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK51444.1 - 8.7e-13 49.2 0.0 1.7e-08 35.1 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family Pkinase PF00069.25 PIK51445.1 - 1.2e-61 208.4 0.0 1.6e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51445.1 - 1.1e-33 116.6 0.0 1.4e-32 113.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK51445.1 - 0.00021 20.2 0.0 0.00032 19.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK51445.1 - 0.0026 16.8 0.0 0.0047 15.9 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK51445.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 PIK51445.1 - 0.019 14.0 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 PIK51445.1 - 0.043 13.7 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CCHC_3 PF13917.6 PIK51446.1 - 3.6e-17 62.0 2.1 5.5e-17 61.5 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK51446.1 - 0.031 14.4 0.7 0.049 13.7 0.7 1.3 1 0 0 1 1 1 0 Zinc knuckle Hs1pro-1_N PF07231.12 PIK51447.1 - 0.017 14.9 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Hs1pro-1 N-terminus RasGEF PF00617.19 PIK51448.1 - 4.6e-57 193.1 1.6 1.1e-56 191.9 1.6 1.7 1 0 0 1 1 1 1 RasGEF domain RhoGEF PF00621.20 PIK51448.1 - 1.4e-32 113.4 1.7 3.2e-32 112.2 1.7 1.7 1 0 0 1 1 1 1 RhoGEF domain RasGEF_N PF00618.20 PIK51448.1 - 1.4e-17 63.8 0.0 5.3e-11 42.7 0.0 2.9 2 0 0 2 2 2 2 RasGEF N-terminal motif DUF4071 PF13281.6 PIK51448.1 - 0.0083 15.2 1.1 0.014 14.5 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4071) PH PF00169.29 PIK51448.1 - 0.0087 16.6 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 PH domain Neural_ProG_Cyt PF06567.11 PIK51448.1 - 0.066 13.4 0.1 4.7 7.5 0.0 2.7 2 0 0 2 2 2 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain Nnf1 PF03980.14 PIK51449.1 - 1.2e-12 48.2 5.9 1.2e-12 48.2 5.9 1.7 2 0 0 2 2 2 1 Nnf1 DUF2252 PF10009.9 PIK51449.1 - 0.0075 15.4 2.1 0.016 14.3 0.7 1.8 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2252) DUF4200 PF13863.6 PIK51449.1 - 0.008 16.6 6.0 0.008 16.6 6.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4200) NTase_sub_bind PF08780.11 PIK51449.1 - 0.018 15.0 2.8 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 Nucleotidyltransferase substrate binding protein like DUF3907 PF13047.6 PIK51449.1 - 0.023 14.7 1.4 0.45 10.5 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3907) Pathogen_betaC1 PF09593.10 PIK51449.1 - 0.05 13.5 0.2 0.11 12.4 0.1 1.6 2 0 0 2 2 2 0 Beta-satellite pathogenicity beta C1 protein DUF1722 PF08349.11 PIK51449.1 - 0.16 12.3 6.5 0.25 11.6 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) UPF0242 PF06785.11 PIK51449.1 - 0.3 11.2 10.7 0.44 10.6 10.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Trypsin PF00089.26 PIK51450.1 - 9.6e-45 153.1 0.0 1.1e-44 152.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK51450.1 - 7.2e-05 23.7 0.0 0.0001 23.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain PRCC PF10253.9 PIK51451.1 - 2.8e-35 123.1 14.7 2.8e-35 123.1 14.7 3.5 2 2 1 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting Serinc PF03348.15 PIK51452.1 - 5.1e-98 328.8 22.6 6.3e-98 328.5 22.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) AMP-binding PF00501.28 PIK51453.1 - 1.1e-58 198.9 0.0 1.4e-58 198.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.28 PIK51454.1 - 8.8e-21 74.0 0.1 1.2e-20 73.6 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF2956 PF11169.8 PIK51454.1 - 4.7e-05 23.5 0.8 7.1e-05 22.9 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) DUF2675 PF11247.8 PIK51454.1 - 0.034 14.3 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) NAD_binding_2 PF03446.15 PIK51455.1 - 0.14 12.3 2.5 0.14 12.3 2.5 1.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase COMM_domain PF07258.14 PIK51456.1 - 7e-11 42.1 0.1 1.5e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 COMM domain DUF16 PF01519.16 PIK51456.1 - 0.058 13.9 0.4 0.16 12.4 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF4375 PF14300.6 PIK51456.1 - 0.082 13.2 0.1 0.18 12.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) Caskin-Pro-rich PF16907.5 PIK51457.1 - 5.5e-06 26.8 5.3 5.5e-06 26.8 5.3 2.7 2 0 0 2 2 2 1 Proline rich region of Caskin proteins Sema PF01403.19 PIK51458.1 - 3.6e-103 345.6 0.0 4.8e-103 345.2 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 PIK51458.1 - 0.026 15.1 4.3 0.07 13.7 4.3 1.8 1 0 0 1 1 1 0 Plexin repeat Band_7 PF01145.25 PIK51459.1 - 0.00015 21.8 0.0 0.00041 20.4 0.0 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family DeoRC PF00455.22 PIK51459.1 - 0.063 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 DeoR C terminal sensor domain ATP-synt_B PF00430.18 PIK51459.1 - 0.24 11.5 0.1 0.24 11.5 0.1 2.5 3 0 0 3 3 3 0 ATP synthase B/B' CF(0) AAA PF00004.29 PIK51460.1 - 2.3e-94 312.8 0.0 1.3e-45 155.1 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK51460.1 - 2.3e-24 84.9 2.0 1.6e-11 43.8 0.0 3.2 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 PIK51460.1 - 4.2e-21 74.9 1.8 4.2e-21 74.9 1.8 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 PIK51460.1 - 3.7e-14 52.8 0.0 1.4e-05 24.9 0.0 3.0 2 1 1 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK51460.1 - 4.7e-13 49.9 0.4 0.00017 22.0 0.1 4.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 PIK51460.1 - 4.6e-11 43.1 0.0 1.2e-05 25.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 PIK51460.1 - 4.7e-11 42.3 0.0 1.1e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 PIK51460.1 - 2.8e-10 40.5 0.0 0.00015 21.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 PIK51460.1 - 6.7e-10 39.1 0.4 0.00022 21.2 0.0 3.7 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK51460.1 - 3.1e-09 37.2 0.3 0.046 14.0 0.0 3.9 2 2 2 4 4 3 2 AAA domain AAA_18 PF13238.6 PIK51460.1 - 3.3e-08 34.2 0.0 0.015 15.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 PIK51460.1 - 5.1e-08 33.3 0.0 0.0057 17.0 0.0 3.5 3 0 0 3 3 3 2 RNA helicase TIP49 PF06068.13 PIK51460.1 - 6.7e-08 32.1 0.0 0.0079 15.4 0.0 2.8 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 PIK51460.1 - 5.1e-07 29.8 0.0 0.031 14.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 PIK51460.1 - 6e-07 29.4 2.7 1.4e-06 28.2 0.3 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 PIK51460.1 - 8.2e-07 28.6 0.1 0.018 14.4 0.0 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 PIK51460.1 - 9.6e-07 28.7 0.0 0.059 13.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Bac_DnaA PF00308.18 PIK51460.1 - 1.6e-06 28.1 0.1 0.0085 16.0 0.0 2.7 2 0 0 2 2 2 2 Bacterial dnaA protein ABC_tran PF00005.27 PIK51460.1 - 4.8e-06 27.1 0.4 0.0054 17.3 0.0 3.7 3 1 0 3 3 3 1 ABC transporter AAA_25 PF13481.6 PIK51460.1 - 4.8e-06 26.3 0.1 0.75 9.3 0.0 3.5 2 1 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 PIK51460.1 - 5.3e-06 26.5 0.3 0.25 11.2 0.0 3.7 3 1 1 4 4 3 2 ATPase domain predominantly from Archaea AAA_17 PF13207.6 PIK51460.1 - 8.2e-06 26.3 0.0 0.84 10.1 0.0 3.7 3 0 0 3 3 3 2 AAA domain Parvo_NS1 PF01057.17 PIK51460.1 - 2.4e-05 23.6 0.5 0.039 13.0 0.0 2.8 3 0 0 3 3 3 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 PIK51460.1 - 3.3e-05 23.7 0.0 0.085 12.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 PIK51460.1 - 3.7e-05 23.3 0.0 0.11 12.0 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 PIK51460.1 - 4.5e-05 23.8 0.0 0.18 12.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 PIK51460.1 - 7.2e-05 22.8 0.0 0.24 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 PIK51460.1 - 0.00013 21.3 0.0 0.25 10.5 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain Viral_helicase1 PF01443.18 PIK51460.1 - 0.00017 21.4 0.0 0.0033 17.2 0.0 2.6 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 PIK51460.1 - 0.00017 21.3 0.0 0.99 9.1 0.0 3.0 2 2 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.12 PIK51460.1 - 0.00021 21.3 0.1 0.32 10.9 0.0 3.2 3 1 0 3 3 3 1 NACHT domain AAA_3 PF07726.11 PIK51460.1 - 0.00039 20.3 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 PIK51460.1 - 0.00057 19.1 0.0 0.21 10.7 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase PF06745.13 PIK51460.1 - 0.00059 19.2 1.6 2.7 7.3 0.0 3.5 3 1 0 3 3 3 1 KaiC Zeta_toxin PF06414.12 PIK51460.1 - 0.00088 18.6 0.0 0.54 9.5 0.0 2.9 3 0 0 3 3 2 1 Zeta toxin ResIII PF04851.15 PIK51460.1 - 0.0025 17.8 0.0 0.47 10.4 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 PIK51460.1 - 0.0031 17.6 0.0 3 7.9 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Rad17 PF03215.15 PIK51460.1 - 0.0039 17.1 0.0 0.88 9.5 0.0 2.9 2 1 0 2 2 2 1 Rad17 P-loop domain KAP_NTPase PF07693.14 PIK51460.1 - 0.0078 15.5 0.1 0.37 10.0 0.0 3.1 2 2 2 4 4 4 1 KAP family P-loop domain Cytidylate_kin PF02224.18 PIK51460.1 - 0.0081 15.9 0.8 25 4.5 0.0 3.8 4 0 0 4 4 3 0 Cytidylate kinase DUF2075 PF09848.9 PIK51460.1 - 0.0094 15.2 0.1 5.5 6.1 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 PIK51460.1 - 0.012 15.6 0.1 5.9 6.8 0.0 3.1 3 0 0 3 3 3 0 NTPase PhoH PF02562.16 PIK51460.1 - 0.013 15.0 0.2 1.8 8.0 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein SKI PF01202.22 PIK51460.1 - 0.049 13.7 0.4 9.7 6.3 0.0 3.1 3 0 0 3 3 2 0 Shikimate kinase Adeno_IVa2 PF02456.15 PIK51460.1 - 0.12 11.2 0.0 0.93 8.2 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_19 PF13245.6 PIK51460.1 - 0.19 12.1 5.4 15 5.9 0.0 3.6 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.6 PIK51460.1 - 0.77 10.2 5.7 15 6.0 0.1 3.8 2 1 1 3 3 3 0 AAA domain Band_7 PF01145.25 PIK51461.1 - 6.4e-17 62.1 6.5 2e-16 60.5 6.3 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family SKG6 PF08693.10 PIK51461.1 - 0.39 10.2 4.3 0.85 9.1 4.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Peptidase_C14 PF00656.22 PIK51462.1 - 1.4e-22 80.9 0.7 2.8e-22 79.9 0.7 1.6 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 PIK51462.1 - 6.9e-17 61.5 8.9 2.9e-11 43.5 0.3 2.9 3 0 0 3 3 3 2 Death effector domain Ribosomal_L20 PF00453.18 PIK51462.1 - 0.18 11.9 0.0 0.57 10.3 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L20 N_BRCA1_IG PF16158.5 PIK51463.1 - 6.1e-23 81.5 0.0 1.7e-22 80.0 0.0 1.9 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 PIK51463.1 - 2e-11 43.5 6.9 2e-11 43.5 6.9 1.9 2 0 0 2 2 2 1 Zinc finger, ZZ type PB1 PF00564.24 PIK51463.1 - 5.4e-06 26.2 0.3 1.2e-05 25.1 0.3 1.7 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.16 PIK51463.1 - 0.011 16.0 6.4 0.024 14.9 6.4 1.5 1 0 0 1 1 1 0 C1 domain wnt PF00110.19 PIK51464.1 - 2.2e-99 332.9 28.1 2.5e-99 332.8 28.1 1.0 1 0 0 1 1 1 1 wnt family Linker_histone PF00538.19 PIK51464.1 - 0.016 15.6 0.0 0.043 14.2 0.0 1.7 1 0 0 1 1 1 0 linker histone H1 and H5 family Adaptin_N PF01602.20 PIK51466.1 - 2.5e-82 277.1 1.7 4.5e-82 276.3 1.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 PIK51466.1 - 1.6e-35 122.6 0.7 2.4e-31 109.0 0.0 3.7 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 PIK51466.1 - 1.9e-11 44.1 0.3 4.7e-11 42.8 0.3 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 PIK51466.1 - 4.8e-05 23.3 1.2 18 5.9 0.0 6.2 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 PIK51466.1 - 0.00082 19.7 0.0 0.85 10.1 0.0 4.2 3 1 1 4 4 4 2 HEAT repeats Dcc1 PF09724.9 PIK51466.1 - 0.0076 15.6 1.4 0.054 12.8 0.7 2.5 3 0 0 3 3 3 1 Sister chromatid cohesion protein Dcc1 zf-H2C2_2 PF13465.6 PIK51467.1 - 5.4e-17 61.4 28.8 7.2e-06 26.2 0.6 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK51467.1 - 3.7e-13 49.1 34.4 0.019 15.7 1.3 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK51467.1 - 1.2e-12 47.6 34.9 0.009 16.4 1.2 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-met PF12874.7 PIK51467.1 - 4.4e-12 46.0 28.8 0.0017 18.7 1.1 6.0 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK51467.1 - 2.2e-08 34.2 19.5 0.0047 17.2 0.7 4.9 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK51467.1 - 0.00013 21.8 1.0 0.00013 21.8 1.0 5.8 6 0 0 6 6 6 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK51467.1 - 0.0043 17.3 4.5 0.0043 17.3 4.5 4.1 2 1 3 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK51467.1 - 0.0092 15.7 0.2 0.0092 15.7 0.2 3.8 4 0 0 4 4 4 1 C2H2-type zinc-finger domain BolA PF01722.18 PIK51467.1 - 0.11 12.7 3.3 4.1 7.7 0.1 3.0 2 1 1 3 3 3 0 BolA-like protein YyzF PF14116.6 PIK51467.1 - 0.16 12.1 4.4 42 4.3 0.1 3.9 3 0 0 3 3 3 0 YyzF-like protein DUF2256 PF10013.9 PIK51467.1 - 0.37 11.0 9.4 0.46 10.6 0.2 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Vps39_2 PF10367.9 PIK51467.1 - 1.4 9.4 15.4 1.8 9.1 0.2 4.9 3 1 2 5 5 5 0 Vacuolar sorting protein 39 domain 2 GAGA PF09237.11 PIK51467.1 - 1.5 8.7 8.4 2.8 7.8 0.5 3.6 2 1 1 3 3 3 0 GAGA factor zf-FCS PF06467.14 PIK51467.1 - 2.1 8.4 9.6 2.9 7.9 0.2 4.1 4 1 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif zf-MYND PF01753.18 PIK51467.1 - 5.4 7.2 14.3 6.7 6.9 5.9 3.3 2 1 0 2 2 2 0 MYND finger V-SNARE_C PF12352.8 PIK51468.1 - 4.9e-14 52.3 0.8 1.2e-13 51.2 0.8 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 PIK51468.1 - 0.00018 21.3 0.0 0.00041 20.2 0.0 1.6 1 0 0 1 1 1 1 Sec20 Syntaxin_2 PF14523.6 PIK51468.1 - 0.00065 20.0 2.9 0.00065 20.0 2.9 2.0 2 0 0 2 2 2 1 Syntaxin-like protein V-SNARE PF05008.15 PIK51468.1 - 0.013 15.9 1.3 0.013 15.9 1.3 1.7 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus RCC1_2 PF13540.6 PIK51468.1 - 0.11 12.3 0.4 15 5.6 0.0 3.2 2 1 1 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat FapA PF03961.13 PIK51468.1 - 0.72 8.4 8.2 1.2 7.7 3.4 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A wnt PF00110.19 PIK51469.1 - 3.2e-72 243.8 26.0 3.7e-72 243.5 26.0 1.0 1 0 0 1 1 1 1 wnt family Recep_L_domain PF01030.24 PIK51470.1 - 3e-27 95.0 0.5 3.8e-15 56.0 0.0 2.5 2 1 0 2 2 2 2 Receptor L domain Furin-like PF00757.20 PIK51470.1 - 1.7e-23 83.2 68.5 6.7e-19 68.2 38.7 3.2 3 0 0 3 3 3 3 Furin-like cysteine rich region GF_recep_IV PF14843.6 PIK51470.1 - 2.8e-13 49.8 67.4 2.6e-08 33.7 16.9 4.0 2 1 1 3 3 3 3 Growth factor receptor domain IV GF_recep_IV PF14843.6 PIK51471.1 - 3.5e-26 91.5 101.0 1.6e-14 53.8 30.5 4.2 1 1 3 4 4 4 4 Growth factor receptor domain IV Furin-like PF00757.20 PIK51471.1 - 9.2e-20 71.0 99.4 8.9e-08 32.1 22.9 5.3 1 1 3 5 5 5 5 Furin-like cysteine rich region Lectin_C PF00059.21 PIK51472.1 - 1.1e-29 103.4 14.7 1.7e-11 44.8 0.0 4.3 4 0 0 4 4 4 3 Lectin C-type domain GREB1 PF15782.5 PIK51472.1 - 0.14 9.3 11.0 0.17 9.0 11.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PTR2 PF00854.21 PIK51473.1 - 5.7e-85 285.5 11.0 1.1e-39 136.4 4.1 3.2 2 1 1 3 3 3 3 POT family BAMBI PF06211.12 PIK51474.1 - 0.11 12.8 6.9 0.16 12.3 6.9 1.2 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Glyco_transf_10 PF00852.19 PIK51475.1 - 2.4e-44 151.1 0.1 3.4e-44 150.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51475.1 - 7.4e-06 26.4 0.2 1.9e-05 25.1 0.2 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Oxysterol_BP PF01237.18 PIK51476.1 - 1.1e-114 383.2 7.0 3e-114 381.7 7.0 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein NEAT PF05031.12 PIK51476.1 - 0.036 14.7 0.0 0.076 13.6 0.0 1.5 1 0 0 1 1 1 0 Iron Transport-associated domain zf-CCCH PF00642.24 PIK51477.1 - 7e-14 51.3 21.3 0.00011 22.0 0.6 4.6 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 PIK51477.1 - 1.3e-07 31.9 14.8 0.0083 16.3 3.2 3.5 2 2 1 3 3 3 3 Zinc-finger containing family zf-CCCH_2 PF14608.6 PIK51477.1 - 1.4e-07 31.7 36.7 0.035 14.6 3.9 4.7 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 PIK51477.1 - 1.3e-06 28.1 35.9 0.00014 21.6 0.6 4.9 4 2 0 4 4 4 3 CCCH-type zinc finger Torus PF16131.5 PIK51477.1 - 0.001 19.7 17.4 0.13 12.9 0.7 3.9 2 2 2 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 PIK51477.1 - 0.087 12.9 37.7 0.091 12.8 2.3 7.0 5 3 0 5 5 5 0 Zinc finger domain RVT_1 PF00078.27 PIK51478.1 - 3e-18 66.2 0.0 4.6e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_int_SAM_1 PF02899.17 PIK51478.1 - 0.00021 21.5 0.8 0.00065 20.0 0.1 2.2 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK51478.1 - 0.00081 19.8 0.0 0.0017 18.8 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK51478.1 - 0.0019 18.0 0.0 0.0056 16.5 0.0 1.7 1 1 0 1 1 1 1 Phage integrase family MFS_1 PF07690.16 PIK51480.1 - 4.9e-27 94.8 11.8 4.9e-27 94.8 11.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK51480.1 - 1.4e-18 67.0 9.2 1.4e-18 67.0 9.2 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 PIK51480.1 - 0.042 12.1 2.1 1.9 6.7 0.1 2.2 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK51481.1 - 4.5e-08 32.4 0.9 5.7e-08 32.1 0.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK51481.1 - 6.4e-07 28.6 2.7 7.4e-07 28.4 2.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Pkinase PF00069.25 PIK51482.1 - 2.2e-20 73.1 0.0 8.9e-20 71.1 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51482.1 - 6.8e-16 58.3 0.0 1.9e-14 53.6 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK51482.1 - 0.0061 16.5 2.0 0.33 10.8 1.4 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK51482.1 - 0.018 14.4 0.1 0.032 13.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK51482.1 - 0.1 12.2 0.0 0.25 10.9 0.0 1.6 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 PIK51482.1 - 0.19 10.6 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MCM PF00493.23 PIK51483.1 - 8e-104 345.6 0.0 3.5e-103 343.5 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 PIK51483.1 - 1.2e-34 118.8 0.7 2.6e-34 117.8 0.7 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK51483.1 - 1.2e-21 77.0 1.7 3.2e-21 75.6 1.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 PIK51483.1 - 6.9e-19 68.4 1.7 2.4e-18 66.6 1.7 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 PIK51483.1 - 1e-08 34.9 0.1 3.5e-06 26.6 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK51483.1 - 6.4e-07 29.5 0.0 2.7e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK51483.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK51483.1 - 0.033 13.9 0.0 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Glyco_transf_10 PF00852.19 PIK51484.1 - 5.8e-41 140.1 0.9 7.6e-41 139.7 0.9 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51484.1 - 2.2e-07 31.3 0.2 6.6e-07 29.8 0.1 1.9 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal AAA_5 PF07728.14 PIK51485.1 - 1.7e-98 326.1 0.0 6.3e-37 126.6 0.0 3.7 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK51485.1 - 8.9e-08 32.7 0.3 0.064 13.6 0.0 4.7 2 2 2 4 4 4 2 AAA ATPase domain CbbQ_C PF08406.10 PIK51485.1 - 4.4e-07 30.1 0.3 0.0026 18.0 0.2 3.0 3 0 0 3 3 2 2 CbbQ/NirQ/NorQ C-terminal AAA_3 PF07726.11 PIK51485.1 - 1.2e-05 25.2 0.0 0.085 12.7 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK51485.1 - 2.1e-05 24.8 0.0 0.02 15.1 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 PIK51485.1 - 2.1e-05 24.9 0.0 0.011 16.2 0.0 4.0 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 PIK51485.1 - 3.5e-05 23.4 0.0 0.052 13.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 PIK51485.1 - 0.00033 20.7 0.0 0.15 12.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.14 PIK51485.1 - 0.0011 19.2 0.2 1.1 9.4 0.0 3.7 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 PIK51485.1 - 0.0018 18.5 0.0 0.053 13.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 PIK51485.1 - 0.002 18.6 0.4 4 8.0 0.0 3.8 4 0 0 4 4 3 1 ABC transporter Roc PF08477.13 PIK51485.1 - 0.0037 17.5 0.0 0.73 10.1 0.0 3.0 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 PIK51485.1 - 0.0039 17.6 0.0 0.077 13.4 0.0 2.8 2 0 0 2 2 2 1 RNA helicase TniB PF05621.11 PIK51485.1 - 0.014 14.8 0.1 4.1 6.8 0.0 3.0 3 0 0 3 3 3 0 Bacterial TniB protein AAA_18 PF13238.6 PIK51485.1 - 0.024 15.2 0.0 0.16 12.5 0.0 2.6 2 0 0 2 2 1 0 AAA domain AAA_lid_7 PF17867.1 PIK51485.1 - 0.024 14.8 0.2 1.7 8.9 0.1 2.8 2 0 0 2 2 2 0 Midasin AAA lid domain AAA_8 PF12780.7 PIK51485.1 - 0.025 13.9 0.1 4.7 6.5 0.1 3.0 2 1 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_29 PF13555.6 PIK51485.1 - 0.026 14.3 0.0 5.1 6.9 0.0 3.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 PIK51485.1 - 0.031 13.6 0.0 4 6.7 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 PIK51485.1 - 0.037 14.3 0.0 0.3 11.3 0.0 2.7 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 PIK51485.1 - 0.045 13.7 0.0 3.5 7.5 0.0 2.8 2 0 0 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 PIK51485.1 - 0.069 12.9 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Cytidylate kinase Mg_chelatase PF01078.21 PIK51485.1 - 0.1 11.9 0.0 12 5.2 0.0 2.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF745 PF05335.13 PIK51485.1 - 3.8 7.2 6.7 4.8 6.9 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Abhydrolase_3 PF07859.13 PIK51486.1 - 3.2e-52 177.4 0.0 1.2e-37 129.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK51486.1 - 1.2e-10 40.9 0.2 3.7e-10 39.3 0.0 1.8 2 1 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK51486.1 - 0.00082 18.9 0.0 0.003 17.1 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 PIK51487.1 - 1.5e-52 178.5 0.0 7.4e-40 137.0 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK51487.1 - 9.3e-10 38.0 0.1 2.9e-09 36.3 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK51487.1 - 3.4e-05 23.4 0.0 7.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK51487.1 - 0.16 10.8 0.2 0.3 9.9 0.0 1.5 2 0 0 2 2 2 0 Steryl acetyl hydrolase AKAP7_NLS PF10469.9 PIK51488.1 - 1.9e-52 178.2 0.0 2.3e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 PIK51488.1 - 1.3e-15 57.0 0.6 2.7e-15 56.0 0.6 1.6 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 PIK51488.1 - 0.12 12.2 0.0 0.39 10.6 0.0 1.8 1 0 0 1 1 1 0 KH domain Polysacc_deac_3 PF15421.6 PIK51489.1 - 0.091 11.3 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 Putative polysaccharide deacetylase WD40 PF00400.32 PIK51490.1 - 2.2e-25 88.4 9.2 0.00037 21.2 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK51490.1 - 0.00091 19.5 0.0 1.2 9.5 0.0 4.6 3 1 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 PIK51491.1 - 1.2e-15 57.1 0.0 1.7e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK51491.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif NUFIP1 PF10453.9 PIK51492.1 - 1.5e-10 40.7 1.5 1.5e-10 40.7 1.5 3.6 3 0 0 3 3 3 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF1644 PF07800.12 PIK51492.1 - 0.014 15.4 1.8 0.014 15.4 1.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) p450 PF00067.22 PIK51493.1 - 3.5e-88 296.4 0.0 4e-88 296.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Patched PF02460.18 PIK51494.1 - 3.5e-66 223.9 2.9 3.9e-66 223.7 2.9 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK51494.1 - 2.2e-27 95.8 1.8 6.2e-27 94.3 1.8 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK51494.1 - 0.0083 15.1 1.3 0.012 14.6 0.1 1.7 2 0 0 2 2 2 1 MMPL family Sin_N PF04801.13 PIK51495.1 - 8.7e-119 397.5 11.9 8.7e-119 397.5 11.9 2.4 2 1 0 2 2 2 1 Sin-like protein conserved region Dppa2_A PF14049.6 PIK51495.1 - 0.17 12.1 6.4 1.1 9.4 0.5 3.2 2 1 0 2 2 2 0 Dppa2/4 conserved region in higher vertebrates Fe_hyd_lg_C PF02906.14 PIK51496.1 - 4.8e-67 226.1 0.0 3.1e-63 213.7 0.0 2.4 2 0 0 2 2 2 2 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 PIK51496.1 - 8.5e-11 41.8 0.5 1.8e-10 40.7 0.5 1.5 1 0 0 1 1 1 1 Iron hydrogenase small subunit p450 PF00067.22 PIK51497.1 - 5.4e-60 203.5 0.1 6.6e-60 203.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Vault_4 PF17796.1 PIK51497.1 - 0.036 14.2 0.0 0.23 11.5 0.1 2.2 2 0 0 2 2 2 0 Major Vault Protein repeat domain Fibrinogen_C PF00147.18 PIK51498.1 - 5.6e-18 65.5 0.5 6.9e-18 65.3 0.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain VWC PF00093.18 PIK51499.1 - 0.00021 21.6 9.5 0.00021 21.6 9.5 2.0 2 0 0 2 2 2 1 von Willebrand factor type C domain DUF2833 PF11090.8 PIK51500.1 - 0.044 14.2 0.2 0.33 11.4 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2833) Ephrin_rec_like PF07699.13 PIK51500.1 - 0.14 11.9 1.7 0.84 9.4 0.1 2.3 2 0 0 2 2 2 0 Putative ephrin-receptor like Pkinase PF00069.25 PIK51501.1 - 1.3e-53 182.1 0.0 1.5e-53 181.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51501.1 - 1.7e-38 132.4 0.0 2.2e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK51501.1 - 2.3e-05 23.9 0.0 4.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 PIK51501.1 - 0.0027 16.8 0.0 0.0043 16.1 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 PIK51501.1 - 0.0037 16.3 0.0 0.0061 15.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Ins145_P3_rec PF08709.11 PIK51501.1 - 0.048 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Pkinase_fungal PF17667.1 PIK51501.1 - 0.13 11.0 0.0 0.26 10.0 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Mito_carr PF00153.27 PIK51502.1 - 7.8e-55 182.8 4.8 1.8e-18 66.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glycos_trans_3N PF02885.17 PIK51502.1 - 0.15 11.9 0.1 2.1 8.3 0.0 2.5 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain RVT_1 PF00078.27 PIK51503.1 - 9.4e-23 80.9 0.0 1.4e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gpi1 PF05024.15 PIK51504.1 - 2.6e-56 190.7 13.5 6.1e-56 189.5 13.5 1.7 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) BTB_2 PF02214.22 PIK51505.1 - 8.1e-22 77.4 0.0 1.3e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 PIK51505.1 - 0.045 14.0 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain MIP PF00230.20 PIK51507.1 - 6.7e-42 143.7 13.6 1.2e-41 142.9 13.6 1.4 1 1 0 1 1 1 1 Major intrinsic protein DUF2254 PF10011.9 PIK51507.1 - 4.3 6.1 8.0 0.52 9.1 3.1 1.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2254) RT_RNaseH_2 PF17919.1 PIK51509.1 - 5.3e-29 100.2 0.0 1.2e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK51509.1 - 1.8e-17 63.5 0.0 5.7e-17 61.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK51509.1 - 5.5e-16 58.8 0.1 1.1e-15 57.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK51510.1 - 2.3e-18 66.5 0.0 3.9e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK51510.1 - 1.1e-14 54.2 1.2 4.9e-14 52.2 1.8 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK51510.1 - 0.024 14.4 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Vasculin PF15337.6 PIK51510.1 - 0.033 15.0 0.9 0.99 10.3 0.3 3.0 2 0 0 2 2 2 0 Vascular protein family Vasculin-like 1 zf-H2C2 PF09337.10 PIK51510.1 - 1 9.7 3.4 3.4 8.0 3.4 2.0 1 0 0 1 1 1 0 H2C2 zinc finger GARS_A PF01071.19 PIK51511.1 - 3.5e-83 278.1 0.5 5.6e-83 277.5 0.5 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 PIK51511.1 - 2.1e-61 206.8 0.0 3.8e-61 206.0 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase AIRS_C PF02769.22 PIK51511.1 - 2.7e-35 121.8 0.0 2.6e-34 118.6 0.0 2.6 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 PIK51511.1 - 1.1e-26 92.9 0.1 3.6e-26 91.3 0.1 2.0 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain GARS_N PF02844.15 PIK51511.1 - 8e-17 61.8 0.2 5.2e-15 56.0 0.0 3.3 3 1 0 3 3 3 1 Phosphoribosylglycinamide synthetase, N domain AIRS PF00586.24 PIK51511.1 - 3.8e-14 53.1 3.2 1e-13 51.7 2.4 2.2 2 0 0 2 2 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 PIK51511.1 - 1.7e-06 28.2 0.0 7.8e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 PIK51511.1 - 0.00067 19.3 0.1 0.0014 18.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 PIK51511.1 - 0.015 14.9 0.1 0.033 13.8 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.17 PIK51511.1 - 0.028 13.9 0.2 0.092 12.2 0.1 2.0 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 PIK51511.1 - 0.043 13.3 0.1 0.1 12.2 0.1 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp_2 PF08442.10 PIK51511.1 - 0.07 12.7 0.8 0.18 11.4 0.8 1.6 1 0 0 1 1 1 0 ATP-grasp domain Peripla_BP_6 PF13458.6 PIK51511.1 - 0.091 12.4 0.2 0.22 11.1 0.2 1.7 1 0 0 1 1 1 0 Periplasmic binding protein DUF4027 PF13219.6 PIK51511.1 - 0.12 12.2 0.0 0.39 10.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4027) 7tm_1 PF00001.21 PIK51512.1 - 1.3e-37 129.6 4.2 2e-37 129.0 4.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4574 PF15141.6 PIK51512.1 - 0.024 14.5 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Saf_2TM PF18303.1 PIK51512.1 - 0.27 10.8 2.8 0.62 9.6 0.2 2.7 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain Pkinase PF00069.25 PIK51513.1 - 1.4e-30 106.6 0.0 2.3e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51513.1 - 1.2e-15 57.5 0.0 1.6e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK51513.1 - 0.00041 19.8 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK51513.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK51513.1 - 0.22 11.1 0.0 0.47 10.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family FOP_dimer PF09398.10 PIK51514.1 - 3.4e-20 72.1 2.1 3.4e-20 72.1 2.1 1.7 2 0 0 2 2 2 1 FOP N terminal dimerisation domain EF-hand_7 PF13499.6 PIK51514.1 - 3.1e-06 27.5 3.3 8.5e-06 26.1 3.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK51514.1 - 6.1e-06 25.4 3.8 4.2e-05 22.8 0.8 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK51514.1 - 2.5e-05 23.8 3.3 5.6e-05 22.8 0.5 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 PIK51514.1 - 0.003 17.0 0.1 0.003 17.0 0.1 2.4 3 0 0 3 3 3 1 EF hand LisH_2 PF16045.5 PIK51514.1 - 0.022 13.8 0.0 0.04 12.9 0.0 1.5 1 0 0 1 1 1 0 LisH ALS2CR8 PF15299.6 PIK51516.1 - 8.7e-32 110.8 0.0 1.3e-31 110.2 0.0 1.4 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 ADH_zinc_N PF00107.26 PIK51516.1 - 8.9e-23 80.7 0.4 1.5e-22 80.0 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK51516.1 - 2.2e-19 70.8 0.0 4.4e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK51516.1 - 1.2e-05 25.2 0.1 0.0015 18.4 0.1 2.4 2 0 0 2 2 2 2 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 PIK51516.1 - 0.02 14.3 0.8 0.036 13.5 0.8 1.4 1 0 0 1 1 1 0 short chain dehydrogenase SEP PF08059.13 PIK51517.1 - 2.2e-17 63.4 0.2 6.1e-17 62.0 0.2 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 PIK51517.1 - 9.7e-08 32.1 0.1 3.4e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 UBX domain DUF2408 PF10303.9 PIK51517.1 - 0.0065 17.0 1.7 0.078 13.5 0.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2408) Lebercilin PF15619.6 PIK51517.1 - 0.0068 16.1 7.0 0.015 14.9 7.0 1.5 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease ubiquitin PF00240.23 PIK51517.1 - 0.0074 16.0 0.1 0.15 11.8 0.1 2.8 1 1 0 1 1 1 1 Ubiquitin family LRRFIP PF09738.9 PIK51517.1 - 0.012 15.1 1.5 0.012 15.1 1.5 1.8 2 0 0 2 2 2 0 LRRFIP family RgpF PF05045.12 PIK51517.1 - 0.03 13.1 0.1 0.045 12.5 0.1 1.1 1 0 0 1 1 1 0 Rhamnan synthesis protein F TMPIT PF07851.13 PIK51517.1 - 0.18 11.1 3.8 0.11 11.8 2.0 1.4 2 0 0 2 2 2 0 TMPIT-like protein Tup_N PF08581.10 PIK51517.1 - 0.23 11.8 3.9 14 6.1 0.1 3.1 3 0 0 3 3 3 0 Tup N-terminal FAM76 PF16046.5 PIK51517.1 - 1.7 8.0 9.4 0.078 12.3 3.2 1.8 2 0 0 2 2 2 0 FAM76 protein SlyX PF04102.12 PIK51517.1 - 4.4 8.0 6.1 5 7.8 0.2 3.2 2 1 1 3 3 3 0 SlyX Amidase PF01425.21 PIK51518.1 - 5.8e-91 305.7 0.3 2.4e-61 208.1 0.1 2.0 2 0 0 2 2 2 2 Amidase DUF1344 PF07076.11 PIK51518.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Peptidase_C48 PF02902.19 PIK51520.1 - 2.1e-07 31.0 0.0 3.7e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Phage_int_SAM_4 PF13495.6 PIK51520.1 - 0.00046 20.6 0.3 0.034 14.6 0.1 2.3 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain DUF5349 PF17298.2 PIK51520.1 - 1.4 8.6 6.7 0.26 11.0 3.4 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5349) Peptidase_C48 PF02902.19 PIK51521.1 - 1.2e-08 35.1 0.0 1.5e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF1644 PF07800.12 PIK51521.1 - 0.16 12.0 0.5 0.5 10.4 0.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Pentapeptide_2 PF01469.18 PIK51522.1 - 9.6e-11 41.4 29.6 0.0034 17.2 0.3 7.9 7 2 1 8 8 8 5 Pentapeptide repeats (8 copies) PorB PF11565.8 PIK51522.1 - 0.018 15.5 0.5 71 3.9 0.0 4.4 2 1 2 4 4 4 0 Alpha helical Porin B CarboxypepD_reg PF13620.6 PIK51522.1 - 0.033 14.5 16.9 22 5.4 0.2 6.2 4 1 2 7 7 7 0 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 PIK51522.1 - 2.2 8.5 13.3 28 5.0 0.4 5.2 3 1 3 6 6 6 0 SdrD B-like domain TTL PF03133.15 PIK51523.1 - 2.5e-79 266.5 0.3 2.5e-79 266.5 0.3 1.7 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK51523.1 - 1.6e-07 30.9 0.0 0.00017 20.9 0.0 2.7 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK51523.1 - 0.00028 20.2 0.0 0.014 14.6 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Serine_rich PF08824.10 PIK51523.1 - 0.001 19.1 1.0 0.0046 17.0 0.1 2.2 2 0 0 2 2 2 1 Serine rich protein interaction domain ATP-grasp_3 PF02655.14 PIK51523.1 - 0.06 13.4 0.0 0.98 9.4 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain Neurexophilin PF06312.12 PIK51524.1 - 7.4e-11 41.9 0.0 1.6e-10 40.8 0.0 1.5 1 1 0 1 1 1 1 Neurexophilin ABC_tran PF00005.27 PIK51525.1 - 1.3e-28 100.2 0.0 2.4e-28 99.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK51525.1 - 1.8e-20 73.7 10.6 2.3e-20 73.4 10.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK51525.1 - 4.5e-06 26.3 0.1 0.00054 19.5 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 PIK51525.1 - 0.028 14.1 0.4 0.058 13.1 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 PIK51525.1 - 0.048 13.5 0.9 1.5 8.5 0.9 2.6 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 PIK51525.1 - 0.11 12.6 0.8 0.28 11.2 0.2 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_29 PF13555.6 PIK51525.1 - 0.12 12.1 0.1 0.36 10.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane PF00664.23 PIK51526.1 - 2.6e-26 92.9 13.9 2.6e-26 92.9 13.9 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK51526.1 - 1.2e-17 64.8 0.0 2.4e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 PIK51526.1 - 4.2e-06 26.4 0.4 0.0013 18.3 0.4 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 PIK51526.1 - 0.00046 20.3 0.0 0.00089 19.4 0.0 1.4 1 0 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 PIK51526.1 - 0.014 15.3 0.1 0.027 14.4 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_13 PF13166.6 PIK51526.1 - 0.021 13.5 0.0 0.031 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK51526.1 - 0.033 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2157 PF09925.9 PIK51526.1 - 0.082 12.7 2.2 0.18 11.6 0.9 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Asp-Al_Ex PF06826.12 PIK51526.1 - 3.5 7.4 7.7 1.7 8.5 0.0 3.1 3 0 0 3 3 3 0 Predicted Permease Membrane Region SPRY PF00622.28 PIK51527.1 - 5e-18 65.3 0.3 2e-17 63.4 0.1 2.1 2 0 0 2 2 2 1 SPRY domain Collagen PF01391.18 PIK51528.1 - 6.5e-06 25.8 13.3 6.5e-06 25.8 13.3 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) SAICAR_synt PF01259.18 PIK51528.1 - 0.23 11.0 0.1 0.36 10.4 0.1 1.2 1 0 0 1 1 1 0 SAICAR synthetase RCC1 PF00415.18 PIK51529.1 - 2.9e-56 187.9 22.3 5.9e-13 49.2 1.4 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK51529.1 - 3.7e-20 71.2 44.2 4e-07 29.6 3.9 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Sulfotransfer_2 PF03567.14 PIK51530.1 - 3.3e-18 66.5 0.0 4.1e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Chordopox_A13L PF05961.11 PIK51530.1 - 0.1 12.9 0.3 0.43 10.8 0.0 2.2 2 1 0 2 2 2 0 Chordopoxvirus A13L protein Sema PF01403.19 PIK51531.1 - 6.2e-60 203.2 0.7 9.2e-60 202.6 0.7 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 PIK51531.1 - 0.002 18.6 3.4 0.002 18.6 3.4 2.4 2 0 0 2 2 2 1 Plexin repeat DUF1514 PF07438.11 PIK51531.1 - 0.16 11.9 0.0 0.44 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) DUF4558 PF15104.6 PIK51532.1 - 4.3e-22 77.9 7.2 4.3e-22 77.9 7.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4558) PRR18 PF15671.5 PIK51532.1 - 0.014 15.3 0.7 0.018 15.0 0.7 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 CMV_1a PF12467.8 PIK51532.1 - 0.069 13.5 1.7 2.2 8.6 0.5 2.0 1 1 1 2 2 2 0 Cucumber mosaic virus 1a protein family LRR_8 PF13855.6 PIK51533.1 - 1.2e-45 153.1 44.9 7e-11 41.7 0.0 8.1 3 2 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 PIK51533.1 - 4.6e-17 61.8 44.2 5.2e-05 23.5 0.8 9.0 5 3 4 11 11 11 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK51533.1 - 5.8e-16 58.6 9.0 2e-05 24.6 0.1 3.4 3 0 0 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK51533.1 - 3e-07 30.1 17.6 0.0011 18.5 0.3 4.4 3 2 1 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 PIK51533.1 - 5.9e-05 23.1 38.2 1.1 10.1 0.2 12.1 14 1 0 14 14 14 4 Leucine Rich Repeat PDU_like PF15953.5 PIK51533.1 - 0.083 13.0 0.6 11 6.1 0.0 3.2 2 1 1 3 3 3 0 Putative propanediol utilisation SCAN PF02023.17 PIK51534.1 - 5.8e-13 48.5 0.0 9.8e-13 47.7 0.0 1.4 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK51534.1 - 3.3e-07 30.1 2.4 3.3e-07 30.1 2.4 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK51534.1 - 0.03 14.0 0.3 0.062 13.1 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Retrotrans_gag PF03732.17 PIK51534.1 - 0.086 13.1 0.0 8.9 6.7 0.0 2.5 1 1 1 2 2 2 0 Retrotransposon gag protein zf-CCHC_3 PF13917.6 PIK51534.1 - 0.29 11.1 3.0 0.67 10.0 3.0 1.6 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK51535.1 - 1e-36 125.0 0.0 1.9e-36 124.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK51535.1 - 1.7e-35 121.5 0.0 2.8e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK51535.1 - 3.4e-22 79.1 0.0 5.1e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MATalpha_HMGbox PF04769.12 PIK51535.1 - 0.046 13.0 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Lipase PF00151.19 PIK51536.1 - 1.2e-25 90.6 0.0 1.4e-25 90.4 0.0 1.0 1 0 0 1 1 1 1 Lipase Lipase PF00151.19 PIK51537.1 - 5.3e-35 121.3 1.7 6.4e-35 121.0 1.7 1.1 1 0 0 1 1 1 1 Lipase DUF5562 PF17717.1 PIK51537.1 - 0.047 13.7 0.2 0.073 13.0 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5562) Exo_endo_phos_2 PF14529.6 PIK51538.1 - 6.9e-05 22.7 0.0 0.28 11.1 0.0 3.0 2 1 1 3 3 3 2 Endonuclease-reverse transcriptase DUF2115 PF09888.9 PIK51538.1 - 0.022 15.3 0.1 0.26 11.8 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) BTV_NS2 PF04514.12 PIK51538.1 - 0.06 12.2 0.0 0.094 11.5 0.0 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 LRR_8 PF13855.6 PIK51539.1 - 1e-28 98.9 47.1 6.1e-11 41.9 6.2 4.3 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK51539.1 - 5.2e-21 74.4 33.8 2.4e-07 30.9 1.0 5.6 4 1 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK51539.1 - 5.1e-09 35.4 28.2 1.3 9.9 0.1 9.0 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_5 PF13306.6 PIK51539.1 - 1.4e-06 28.3 5.1 0.00053 20.0 0.7 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK51539.1 - 3e-05 23.7 26.2 0.27 11.4 0.5 8.2 9 0 0 9 9 9 3 Leucine Rich repeat LRR_9 PF14580.6 PIK51539.1 - 0.81 9.2 15.0 3.1 7.3 4.2 2.9 1 1 3 4 4 4 0 Leucine-rich repeat DUF3557 PF12078.8 PIK51539.1 - 4.9 7.1 9.9 8.2 6.4 4.7 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3557) LRR_8 PF13855.6 PIK51540.1 - 7.9e-14 51.2 25.7 4.2e-07 29.6 3.4 4.2 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK51540.1 - 1.7e-08 34.6 30.2 0.0042 17.5 5.3 4.6 3 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK51540.1 - 0.00042 19.9 3.4 0.00053 19.5 2.4 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 PIK51540.1 - 0.0075 16.7 22.7 1.8 9.4 0.4 6.7 5 2 1 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK51540.1 - 5.6 7.3 22.6 37 4.7 0.1 6.3 6 1 0 6 6 6 0 Leucine Rich repeat LRR_4 PF12799.7 PIK51541.1 - 1.9e-23 82.1 38.1 6.9e-07 29.5 5.9 5.6 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK51541.1 - 1.5e-21 75.9 36.4 5.3e-11 42.1 0.8 5.0 1 1 4 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 PIK51541.1 - 3.1e-07 30.1 11.1 0.00076 19.0 7.4 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 PIK51541.1 - 1.4e-06 28.3 4.5 1.4e-06 28.3 4.5 2.2 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK51541.1 - 3.5e-06 26.8 35.8 0.023 15.2 0.0 9.0 10 0 0 10 10 10 4 Leucine Rich Repeat DIRP PF06584.13 PIK51541.1 - 0.052 13.7 0.0 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 DIRP F5_F8_type_C PF00754.25 PIK51542.1 - 2.1e-05 24.7 0.0 2.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain Porin_10 PF14121.6 PIK51543.1 - 0.13 10.8 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Putative porin DUF836 PF05768.14 PIK51544.1 - 1e-16 61.1 0.2 1.3e-16 60.7 0.2 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 PIK51544.1 - 0.00032 20.8 0.1 0.00049 20.3 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin TPR_1 PF00515.28 PIK51545.1 - 1e-66 218.2 60.4 5.5e-06 26.0 0.0 21.7 22 2 0 22 22 21 14 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51545.1 - 3.9e-54 176.5 41.8 4.4e-05 23.3 0.0 20.7 18 3 2 20 20 20 9 Tetratricopeptide repeat TPR_11 PF13414.6 PIK51545.1 - 4.5e-46 154.3 40.1 1.2e-06 28.0 0.7 16.6 15 3 3 18 18 17 10 TPR repeat TPR_8 PF13181.6 PIK51545.1 - 2.3e-39 130.3 24.1 0.0042 17.2 0.0 17.7 19 0 0 19 19 18 8 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51545.1 - 5.5e-32 110.2 15.1 1.9e-05 25.2 0.0 12.8 8 4 5 13 13 13 7 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51545.1 - 5.8e-31 106.5 9.6 3.5e-05 23.9 0.1 11.7 6 4 6 13 13 13 7 Tetratricopeptide repeat TPR_17 PF13431.6 PIK51545.1 - 7.9e-30 101.1 39.7 0.00018 21.6 0.7 17.5 18 0 0 18 18 18 5 Tetratricopeptide repeat TPR_19 PF14559.6 PIK51545.1 - 1e-29 102.8 22.6 3e-06 27.6 0.0 11.3 8 3 4 12 12 11 6 Tetratricopeptide repeat TPR_12 PF13424.6 PIK51545.1 - 8.7e-27 93.2 25.6 8.6e-08 32.4 0.1 12.0 7 6 4 12 12 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 PIK51545.1 - 1.9e-21 74.9 11.2 0.24 12.3 0.0 14.1 6 3 10 16 16 15 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK51545.1 - 1.7e-17 62.1 10.3 0.15 12.2 0.0 12.1 13 0 0 13 13 11 4 Tetratricopeptide repeat TPR_6 PF13174.6 PIK51545.1 - 3.2e-14 52.5 19.9 1.6 9.5 0.0 12.6 13 0 0 13 13 11 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51545.1 - 1.6e-11 44.3 31.4 2.1e-05 24.6 0.2 7.6 6 1 2 8 8 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 PIK51545.1 - 1.7e-06 27.7 20.0 0.27 11.2 0.0 9.5 10 1 1 11 11 9 2 Tetratricopeptide repeat MIT PF04212.18 PIK51545.1 - 9.9e-05 22.3 10.2 3.2 7.9 0.1 7.7 5 3 2 7 7 7 1 MIT (microtubule interacting and transport) domain TPR_20 PF14561.6 PIK51545.1 - 0.0001 22.6 7.4 7.4 7.0 0.0 6.4 5 2 1 7 7 7 0 Tetratricopeptide repeat COPI_C PF06957.11 PIK51545.1 - 0.0012 17.7 0.4 0.7 8.6 0.1 2.5 2 0 0 2 2 2 2 Coatomer (COPI) alpha subunit C-terminus TOM20_plant PF06552.12 PIK51545.1 - 0.0041 16.9 4.3 0.32 10.7 0.0 4.8 3 2 2 6 6 6 1 Plant specific mitochondrial import receptor subunit TOM20 Coatomer_E PF04733.14 PIK51545.1 - 0.0068 15.9 1.8 1.4 8.3 0.0 3.9 3 2 0 3 3 3 1 Coatomer epsilon subunit TPR_21 PF09976.9 PIK51545.1 - 0.01 15.5 7.7 5 6.8 0.0 5.4 4 2 1 5 5 5 0 Tetratricopeptide repeat-like domain DUF3856 PF12968.7 PIK51545.1 - 0.063 13.3 3.3 2 8.5 0.0 4.6 5 2 1 7 7 5 0 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 PIK51545.1 - 0.065 13.9 0.0 55 4.8 0.0 4.7 6 0 0 6 6 3 0 Tetratricopeptide repeat HemY_N PF07219.13 PIK51545.1 - 0.07 13.3 0.0 8.6 6.6 0.0 3.3 3 0 0 3 3 3 0 HemY protein N-terminus DUF627 PF04781.12 PIK51545.1 - 0.13 12.3 2.0 5.3 7.1 0.0 4.0 4 0 0 4 4 3 0 Protein of unknown function (DUF627) NARP1 PF12569.8 PIK51545.1 - 0.47 9.3 11.3 4.8 6.0 0.1 5.1 5 1 0 5 5 5 0 NMDA receptor-regulated protein 1 BTAD PF03704.17 PIK51545.1 - 1.1 9.7 4.6 6.7 7.1 0.1 4.4 6 1 1 7 7 6 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 PIK51545.1 - 2.8 8.1 14.6 11 6.2 0.1 6.9 5 2 2 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 PIK51546.1 - 4.6e-09 35.8 0.0 3.2e-05 23.5 0.1 2.2 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 PIK51546.1 - 7.1e-05 22.5 0.5 0.0027 17.5 1.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51546.1 - 0.00089 19.2 0.6 0.019 15.1 1.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK51546.1 - 0.0015 18.8 0.2 0.0032 17.7 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK51546.1 - 0.0064 17.1 0.0 0.0092 16.6 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51546.1 - 0.026 14.7 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK51546.1 - 0.033 14.4 1.5 0.14 12.5 2.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC_CDC26 PF10471.9 PIK51546.1 - 0.1 13.4 0.0 0.14 13.0 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF5066 PF16728.5 PIK51546.1 - 0.13 11.6 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5066) TPR_11 PF13414.6 PIK51547.1 - 0.0025 17.5 0.1 0.0041 16.8 0.1 1.4 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 PIK51547.1 - 0.021 14.7 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK51547.1 - 0.1 12.8 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat UDPGT PF00201.18 PIK51548.1 - 4.2e-95 319.4 0.1 5.3e-95 319.1 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK51548.1 - 8.9e-08 32.3 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain TsaE PF02367.17 PIK51548.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Glyco_transf_28 PF03033.20 PIK51548.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Mu-like_Pro PF10123.9 PIK51548.1 - 0.2 11.2 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 Mu-like prophage I protein Sterol-sensing PF12349.8 PIK51549.1 - 1.2e-17 64.1 8.0 2.2e-17 63.3 8.0 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 PIK51549.1 - 1.4e-08 33.3 5.2 1.7e-08 33.1 5.2 1.1 1 0 0 1 1 1 1 Patched family HMG-CoA_red PF00368.18 PIK51550.1 - 8.3e-129 429.8 4.7 1e-128 429.5 4.7 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase DUF296 PF03479.15 PIK51550.1 - 0.077 13.4 0.4 0.42 11.0 0.0 2.4 2 1 0 3 3 3 0 Plants and Prokaryotes Conserved (PCC) domain FAM184 PF15665.5 PIK51551.1 - 0.0086 15.9 2.9 0.0086 15.9 2.9 3.2 2 1 1 3 3 3 2 Family with sequence similarity 184, A and B Shugoshin_N PF07558.11 PIK51551.1 - 0.012 15.5 0.3 0.012 15.5 0.3 3.0 3 1 0 3 3 3 0 Shugoshin N-terminal coiled-coil region Spore_Cse60 PF10957.8 PIK51551.1 - 0.013 15.5 0.5 3.4 7.8 0.1 2.7 2 0 0 2 2 2 0 Sporulation protein Cse60 DUF725 PF05267.12 PIK51551.1 - 1.8 8.6 8.8 0.23 11.4 2.9 2.7 3 2 0 3 3 3 0 Protein of unknown function (DUF725) zf-H2C2_2 PF13465.6 PIK51552.1 - 3.3e-12 46.2 12.1 3.4e-07 30.4 4.0 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK51552.1 - 1.3e-11 44.3 30.3 0.00053 20.3 5.6 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK51552.1 - 2.4e-07 31.0 25.9 0.0011 19.6 3.8 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK51552.1 - 0.0061 16.5 0.9 0.0061 16.5 0.9 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 PIK51552.1 - 0.074 13.7 9.0 12 6.6 0.2 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-met PF12874.7 PIK51552.1 - 0.16 12.4 11.6 1.5 9.3 1.2 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK51552.1 - 1.5 9.2 9.1 1.8 9.0 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding TERB2 PF15101.6 PIK51553.1 - 2.5e-33 115.9 1.1 3.5e-33 115.4 1.1 1.2 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 PIK51554.1 - 3.6e-37 128.7 0.0 5e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Tetraspanin PF00335.20 PIK51554.1 - 0.068 12.9 0.0 0.068 12.9 0.0 1.5 2 0 0 2 2 2 0 Tetraspanin family Neur_chan_LBD PF02931.23 PIK51555.1 - 1.4e-21 76.9 0.0 1.5e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Ion_trans PF00520.31 PIK51556.1 - 2.2e-59 200.6 10.1 3.4e-59 200.1 10.1 1.2 1 0 0 1 1 1 1 Ion transport protein Chs7 PF12271.8 PIK51556.1 - 0.032 13.6 9.3 0.036 13.4 1.4 3.1 3 0 0 3 3 3 0 Chitin synthase export chaperone Ion_trans PF00520.31 PIK51557.1 - 2.5e-174 577.1 66.6 3e-67 226.4 20.8 3.5 3 1 0 3 3 3 3 Ion transport protein GPHH PF16905.5 PIK51557.1 - 1.7e-27 94.9 0.1 3.9e-27 93.8 0.1 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.11 PIK51557.1 - 2.8e-27 94.7 0.1 6.6e-27 93.5 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.12 PIK51557.1 - 2.3e-15 56.2 55.7 2.7e-06 26.4 5.3 5.8 4 3 1 5 5 5 5 Polycystin cation channel I-set PF07679.16 PIK51559.1 - 1.8e-215 697.8 0.0 1.2e-17 63.8 0.0 17.1 17 0 0 17 17 17 17 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK51559.1 - 4.6e-205 664.8 30.1 2.5e-16 60.1 0.0 17.3 17 0 0 17 17 17 16 Immunoglobulin domain Ig_2 PF13895.6 PIK51559.1 - 8.2e-145 471.5 16.3 3e-12 46.7 0.0 16.8 16 1 1 17 17 17 16 Immunoglobulin domain ig PF00047.25 PIK51559.1 - 1.2e-112 368.3 3.0 2.9e-09 37.0 0.0 17.6 16 2 0 16 16 16 14 Immunoglobulin domain V-set PF07686.17 PIK51559.1 - 3.9e-62 207.2 30.3 3.7e-05 23.9 0.2 24.3 17 9 7 24 24 24 13 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK51559.1 - 5.4e-40 135.4 15.7 0.0064 16.5 0.0 15.4 14 1 1 15 15 15 9 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK51559.1 - 3.3e-23 81.9 0.0 0.051 14.0 0.0 13.7 16 0 0 16 16 16 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK51559.1 - 3.4e-23 81.7 0.0 2.3 8.5 0.0 13.4 14 0 0 14 14 14 4 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK51559.1 - 3.1e-22 77.9 0.0 0.38 10.3 0.0 11.9 13 0 0 13 13 13 6 Immunoglobulin domain Izumo-Ig PF16706.5 PIK51559.1 - 2.9e-16 59.3 0.1 0.56 10.3 0.0 11.5 13 0 0 13 13 12 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 PIK51559.1 - 1.5e-13 50.9 0.0 3.8 7.8 0.0 10.7 12 0 0 12 12 11 2 Natural killer cell receptor 2B4 V-set_CD47 PF08204.11 PIK51559.1 - 1.6e-11 44.3 1.9 0.21 11.5 0.0 10.5 10 2 1 12 12 12 2 CD47 immunoglobulin-like domain DUF11 PF01345.18 PIK51559.1 - 0.022 15.1 13.0 0.18 12.1 0.0 6.0 6 0 0 6 6 6 0 Domain of unknown function DUF11 I-set PF07679.16 PIK51560.1 - 2.7e-248 803.0 0.0 1.2e-15 57.3 0.0 16.8 16 0 0 16 16 16 16 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK51560.1 - 3.7e-237 767.7 26.2 2.1e-16 60.3 0.0 17.3 17 0 0 17 17 17 16 Immunoglobulin domain Ig_2 PF13895.6 PIK51560.1 - 1.5e-165 538.0 9.7 6.1e-12 45.7 0.0 16.6 16 0 0 16 16 16 16 Immunoglobulin domain ig PF00047.25 PIK51560.1 - 2.1e-145 473.3 0.1 3.7e-09 36.6 0.0 16.5 16 0 0 16 16 16 16 Immunoglobulin domain V-set PF07686.17 PIK51560.1 - 8.4e-64 212.6 33.8 0.00082 19.5 0.0 26.8 17 11 5 22 22 22 14 Immunoglobulin V-set domain EGF_CA PF07645.15 PIK51560.1 - 8e-59 195.6 98.1 7.2e-12 45.3 5.1 9.3 8 0 0 8 8 8 7 Calcium-binding EGF domain Ig_5 PF16681.5 PIK51560.1 - 4.5e-43 145.6 0.0 0.041 14.3 0.0 16.9 15 1 1 16 16 16 9 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TSP_1 PF00090.19 PIK51560.1 - 1.2e-42 143.8 50.6 5.2e-12 45.8 5.6 5.4 4 0 0 4 4 4 4 Thrombospondin type 1 domain C2-set_2 PF08205.12 PIK51560.1 - 1.8e-41 140.1 13.6 0.029 14.4 0.0 16.5 16 0 0 16 16 16 8 CD80-like C2-set immunoglobulin domain cEGF PF12662.7 PIK51560.1 - 1.4e-38 130.4 65.3 3.3e-08 33.3 4.1 10.2 9 0 0 9 9 9 8 Complement Clr-like EGF-like Ig_6 PF18452.1 PIK51560.1 - 4.9e-37 125.3 8.8 0.01 15.4 0.0 17.6 18 0 0 18 18 18 8 Immunoglobulin domain G2F PF07474.12 PIK51560.1 - 3.3e-32 111.8 1.1 7e-32 110.7 1.1 1.5 1 0 0 1 1 1 1 G2F domain Izumo-Ig PF16706.5 PIK51560.1 - 1.6e-24 85.7 13.5 0.011 15.8 0.0 15.8 18 1 0 18 18 17 5 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 PIK51560.1 - 3.8e-18 65.7 0.1 4.4 7.5 0.0 12.6 13 0 0 13 13 13 3 Natural killer cell receptor 2B4 EGF PF00008.27 PIK51560.1 - 3.4e-15 56.0 94.8 5.9e-05 23.3 4.9 9.2 8 0 0 8 8 7 5 EGF-like domain FXa_inhibition PF14670.6 PIK51560.1 - 4.1e-13 49.4 132.2 6.6e-06 26.3 7.9 9.5 10 0 0 10 10 7 5 Coagulation Factor Xa inhibitory site Ig_C17orf99 PF17736.1 PIK51560.1 - 2e-11 43.7 1.9 2 8.5 0.0 12.1 14 2 0 14 14 13 1 C17orf99 Ig domain C2-set PF05790.15 PIK51560.1 - 1.1e-10 41.5 0.0 0.85 9.8 0.0 10.8 12 0 0 12 12 12 1 Immunoglobulin C2-set domain EGF_3 PF12947.7 PIK51560.1 - 3.3e-09 36.8 79.4 0.018 15.2 3.0 8.5 7 0 0 7 7 7 5 EGF domain V-set_CD47 PF08204.11 PIK51560.1 - 6.2e-06 26.2 4.5 12 5.9 0.0 8.9 10 1 0 10 10 10 0 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 PIK51560.1 - 1.3e-05 24.9 4.2 1.7 8.5 0.0 8.0 9 0 0 9 9 9 1 Adenovirus E3 region protein CR1 hEGF PF12661.7 PIK51560.1 - 0.017 15.7 87.5 0.021 15.5 1.7 9.8 9 0 0 9 9 7 0 Human growth factor-like EGF Ribosomal_S13 PF00416.22 PIK51561.1 - 3.1e-37 127.8 0.2 3.8e-37 127.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 PIK51561.1 - 0.11 11.3 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Sdh5 PF03937.16 PIK51561.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase Vps52 PF04129.12 PIK51562.1 - 7e-159 529.8 23.3 5.3e-90 302.6 11.2 3.0 1 1 1 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 PIK51562.1 - 4.1e-13 48.7 20.3 8.5e-13 47.6 3.8 3.1 2 1 1 3 3 3 2 Exocyst complex component Sec3 COG2 PF06148.11 PIK51562.1 - 0.001 19.2 1.0 0.011 15.8 0.8 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Cep57_MT_bd PF06657.13 PIK51562.1 - 0.0047 17.4 1.1 0.11 12.9 0.2 3.1 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 DnaG_DnaB_bind PF08278.11 PIK51562.1 - 0.026 15.1 0.3 7.2 7.2 0.0 3.1 3 1 0 3 3 3 0 DNA primase DnaG DnaB-binding nsp7 PF08716.10 PIK51562.1 - 0.034 14.8 0.4 0.32 11.6 0.0 2.5 2 0 0 2 2 2 0 nsp7 replicase ATG16 PF08614.11 PIK51562.1 - 0.064 13.5 2.3 2.5 8.3 0.6 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 PIK51562.1 - 0.075 13.1 6.8 0.09 12.8 1.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) KIX PF02172.16 PIK51562.1 - 2 8.7 9.5 11 6.3 1.8 4.2 3 1 1 4 4 4 0 KIX domain CENP-F_leu_zip PF10473.9 PIK51562.1 - 2.2 8.3 9.4 1.4 8.9 0.2 3.3 2 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 dsrm PF00035.26 PIK51563.1 - 3.2e-13 50.2 0.5 2.2e-10 41.1 0.2 2.9 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK51563.1 - 0.14 12.5 2.6 21 5.5 1.3 3.8 3 1 0 3 3 3 0 double strand RNA binding domain from DEAD END PROTEIN 1 EST1 PF10374.9 PIK51564.1 - 0.13 12.9 2.9 0.35 11.5 2.9 1.7 1 0 0 1 1 1 0 Telomerase activating protein Est1 Gamma_PGA_hydro PF05908.11 PIK51564.1 - 0.45 9.9 3.4 0.48 9.8 1.1 1.9 1 1 1 2 2 2 0 Poly-gamma-glutamate hydrolase Endonuc_Holl PF10107.9 PIK51564.1 - 0.52 10.1 6.7 65 3.3 6.7 2.3 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase GTP-bdg_M PF16360.5 PIK51564.1 - 7.6 7.2 9.5 0.36 11.5 0.2 2.8 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region ZU5 PF00791.20 PIK51565.1 - 5.1e-13 49.2 0.2 9.1e-13 48.4 0.2 1.4 1 0 0 1 1 1 1 ZU5 domain DUF4994 PF16385.5 PIK51566.1 - 0.058 13.3 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function TSC22 PF01166.18 PIK51567.1 - 0.0043 17.3 0.6 0.0043 17.3 0.6 2.0 2 0 0 2 2 2 1 TSC-22/dip/bun family fn3_6 PF17766.1 PIK51567.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.4 1 1 0 1 1 1 0 Fibronectin type-III domain bZIP_1 PF00170.21 PIK51567.1 - 0.37 10.9 7.6 0.091 12.9 3.7 2.0 2 0 0 2 2 2 0 bZIP transcription factor YabA PF06156.13 PIK51567.1 - 0.37 11.4 9.1 0.25 12.0 2.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA FAA_hydro_N_2 PF18288.1 PIK51567.1 - 0.4 11.1 2.0 0.6 10.6 0.2 2.2 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 ATG16 PF08614.11 PIK51567.1 - 0.42 10.8 12.2 0.65 10.2 12.2 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Cep57_MT_bd PF06657.13 PIK51567.1 - 0.93 10.0 6.9 1.3 9.6 2.9 2.6 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 TMEM154 PF15102.6 PIK51568.1 - 0.00052 19.9 0.0 0.00065 19.6 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Sigma_reg_N PF13800.6 PIK51568.1 - 0.00068 19.9 1.0 0.0037 17.5 0.5 2.1 1 1 1 2 2 2 1 Sigma factor regulator N-terminal Protocadherin PF08374.11 PIK51568.1 - 0.0013 18.8 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 Protocadherin TMEM171 PF15471.6 PIK51568.1 - 0.0028 16.7 0.0 0.0035 16.4 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein family 171 TMEM51 PF15345.6 PIK51568.1 - 0.0092 15.8 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 DUF2207 PF09972.9 PIK51568.1 - 0.021 13.6 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Rax2 PF12768.7 PIK51568.1 - 0.031 13.7 0.0 0.059 12.8 0.0 1.5 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Orf78 PF06024.12 PIK51568.1 - 0.037 14.3 0.1 0.066 13.5 0.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Syndecan PF01034.20 PIK51568.1 - 0.055 13.4 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Mid2 PF04478.12 PIK51568.1 - 0.056 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SIT PF15330.6 PIK51568.1 - 0.062 13.7 0.2 0.12 12.9 0.2 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF2681 PF10883.8 PIK51568.1 - 0.071 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Ly49 PF08391.10 PIK51568.1 - 0.092 13.1 0.6 0.17 12.3 0.6 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Adeno_E3_CR2 PF02439.15 PIK51568.1 - 0.12 12.1 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NACHT PF05729.12 PIK51569.1 - 9.7e-18 64.6 0.1 3e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 PIK51569.1 - 0.0021 18.3 0.0 0.0057 16.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 PIK51569.1 - 0.2 11.2 0.0 0.72 9.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain ZU5 PF00791.20 PIK51570.1 - 4.5e-11 43.0 0.1 1.3e-10 41.5 0.1 1.8 1 0 0 1 1 1 1 ZU5 domain PH_3 PF14593.6 PIK51570.1 - 0.024 14.7 8.0 0.51 10.5 0.0 3.7 4 0 0 4 4 4 0 PH domain NACHT PF05729.12 PIK51571.1 - 1.9e-13 50.7 0.2 9.6e-13 48.4 0.0 2.2 3 0 0 3 3 3 1 NACHT domain Ig_3 PF13927.6 PIK51571.1 - 4.8e-07 30.3 2.9 0.0052 17.3 0.1 4.2 4 0 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK51571.1 - 3.4e-06 27.2 1.3 0.00015 21.9 0.5 2.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain Sigma_reg_N PF13800.6 PIK51571.1 - 8.2e-05 22.8 1.3 0.00021 21.5 1.3 1.7 1 0 0 1 1 1 1 Sigma factor regulator N-terminal ig PF00047.25 PIK51571.1 - 0.00014 21.9 3.1 0.19 11.9 0.2 4.1 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK51571.1 - 0.0027 17.8 0.9 0.029 14.4 0.2 2.9 3 0 0 3 3 3 1 Immunoglobulin I-set domain AAA_25 PF13481.6 PIK51571.1 - 0.013 15.1 0.0 0.035 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK51571.1 - 0.014 15.7 0.0 0.036 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Orf78 PF06024.12 PIK51571.1 - 0.027 14.8 0.5 0.07 13.4 0.5 1.7 1 0 0 1 1 1 0 Orf78 (ac78) C2-set_2 PF08205.12 PIK51571.1 - 0.028 14.5 0.1 0.16 12.1 0.1 2.2 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain TMEM154 PF15102.6 PIK51571.1 - 0.064 13.2 1.6 0.16 11.9 1.6 1.6 1 0 0 1 1 1 0 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK51571.1 - 0.099 12.2 1.1 0.31 10.7 1.1 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family NACHT PF05729.12 PIK51573.1 - 7.7e-18 65.0 0.3 3.2e-17 62.9 0.0 2.3 3 0 0 3 3 2 1 NACHT domain V-set PF07686.17 PIK51573.1 - 1.1e-09 38.5 1.1 0.00014 22.0 0.0 3.3 4 0 0 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 PIK51573.1 - 1.7e-07 31.3 2.8 1.4 9.1 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin domain AAA_22 PF13401.6 PIK51573.1 - 3e-06 27.5 0.0 1.1e-05 25.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain Ig_3 PF13927.6 PIK51573.1 - 7.2e-06 26.5 1.5 0.081 13.5 0.0 5.2 5 0 0 5 5 5 1 Immunoglobulin domain NB-ARC PF00931.22 PIK51573.1 - 0.00018 20.8 0.0 0.00038 19.7 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TMEM154 PF15102.6 PIK51573.1 - 0.00028 20.8 0.5 0.00071 19.5 0.5 1.6 1 0 0 1 1 1 1 TMEM154 protein family AAA_16 PF13191.6 PIK51573.1 - 0.0022 18.4 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Ig_5 PF16681.5 PIK51573.1 - 0.0037 17.6 0.1 0.33 11.4 0.0 3.6 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK51573.1 - 0.004 17.2 2.9 0.033 14.3 0.1 3.2 3 1 0 3 3 2 1 CD80-like C2-set immunoglobulin domain AAA_25 PF13481.6 PIK51573.1 - 0.0074 15.9 0.0 0.026 14.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK51573.1 - 0.013 15.9 0.0 0.073 13.5 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Tmemb_9 PF05434.11 PIK51573.1 - 0.075 12.9 0.2 0.17 11.8 0.2 1.5 1 0 0 1 1 1 0 TMEM9 EphA2_TM PF14575.6 PIK51573.1 - 0.087 13.7 0.1 0.26 12.2 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 PIK51573.1 - 0.11 12.8 1.5 0.12 12.6 0.2 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator IstB_IS21 PF01695.17 PIK51573.1 - 0.16 11.7 0.3 0.62 9.8 0.0 2.2 2 1 0 2 2 2 0 IstB-like ATP binding protein FPP PF05911.11 PIK51574.1 - 8.1e-05 21.0 23.2 0.00011 20.6 23.2 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil APG6_N PF17675.1 PIK51574.1 - 0.55 10.8 31.3 0.05 14.1 16.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 PIK51574.1 - 0.75 9.6 20.9 1 9.2 8.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Exo_endo_phos_2 PF14529.6 PIK51575.1 - 1.1e-08 35.0 0.0 1.6e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK51575.1 - 1.5e-06 27.9 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Uso1_p115_C PF04871.13 PIK51575.1 - 0.093 13.1 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region NACHT PF05729.12 PIK51576.1 - 7.2e-06 26.0 0.0 1.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK51576.1 - 1.3e-05 25.4 0.0 0.0095 16.1 0.1 3.1 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK51576.1 - 0.00032 21.2 0.5 1.8 9.3 0.1 4.2 5 0 0 5 5 5 1 Immunoglobulin domain TMEM154 PF15102.6 PIK51576.1 - 0.00073 19.5 0.0 0.0026 17.7 0.0 1.9 2 0 0 2 2 2 1 TMEM154 protein family ig PF00047.25 PIK51576.1 - 0.0076 16.4 0.3 2.1 8.6 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin domain HPS3_N PF14761.6 PIK51577.1 - 1.2e-05 24.9 3.9 0.00064 19.3 0.2 3.5 3 1 1 4 4 4 2 Hermansky-Pudlak syndrome 3 A_deaminase_N PF08451.11 PIK51577.1 - 2.1e-05 24.7 0.1 4.9e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal Beta_propel PF09826.9 PIK51577.1 - 0.0013 17.7 0.5 0.0017 17.3 0.5 1.2 1 0 0 1 1 1 1 Beta propeller domain NHL PF01436.21 PIK51577.1 - 0.014 15.4 0.0 3.8 7.7 0.0 2.9 2 0 0 2 2 2 0 NHL repeat Glu_cyclase_2 PF05096.12 PIK51577.1 - 0.085 12.3 0.1 0.47 9.8 0.0 2.2 2 1 1 3 3 3 0 Glutamine cyclotransferase Ig_3 PF13927.6 PIK51578.1 - 9.2e-09 35.8 0.3 5e-05 23.8 0.1 3.6 3 0 0 3 3 3 1 Immunoglobulin domain NACHT PF05729.12 PIK51578.1 - 1e-07 32.0 0.1 5.5e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 NACHT domain V-set PF07686.17 PIK51578.1 - 4.8e-06 26.7 0.2 0.01 16.0 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK51578.1 - 3.7e-05 23.7 0.3 0.00016 21.7 0.1 2.2 3 0 0 3 3 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK51578.1 - 0.0022 18.1 4.3 0.087 13.0 0.1 3.9 3 2 1 4 4 4 1 Immunoglobulin domain TMEM154 PF15102.6 PIK51578.1 - 0.0038 17.1 0.2 0.0074 16.2 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family Ig_6 PF18452.1 PIK51578.1 - 0.0078 15.8 0.5 0.16 11.5 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain ATPase PF06745.13 PIK51578.1 - 0.031 13.6 0.1 0.09 12.1 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 PIK51578.1 - 0.053 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Msap1 PF17077.5 PIK51578.1 - 0.056 12.6 0.1 0.089 12.0 0.1 1.2 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 Adeno_E3_CR1 PF02440.15 PIK51578.1 - 0.075 12.8 0.6 3.2 7.6 0.6 2.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Herpes_gE PF02480.16 PIK51578.1 - 0.078 11.7 2.1 2.7 6.7 0.2 2.4 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E Ig_2 PF13895.6 PIK51578.1 - 0.078 13.3 2.5 0.49 10.8 0.7 3.2 4 1 0 4 4 3 0 Immunoglobulin domain DUF4064 PF13273.6 PIK51578.1 - 0.088 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF2075 PF09848.9 PIK51578.1 - 0.1 11.9 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Pkinase_Tyr PF07714.17 PIK51580.1 - 2.3e-29 102.5 0.0 6.4e-29 101.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51580.1 - 1.4e-23 83.6 0.0 3e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK51580.1 - 5.7e-12 45.6 0.0 1.2e-06 28.5 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK51580.1 - 3.1e-07 30.9 0.3 0.0066 17.0 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Kinase-like PF14531.6 PIK51580.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like V-set PF07686.17 PIK51581.1 - 8.5e-06 25.9 0.2 0.054 13.7 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK51581.1 - 2.8e-05 24.6 3.5 0.063 13.9 0.0 5.2 4 1 0 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK51581.1 - 0.00014 22.0 0.8 0.45 10.7 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK51581.1 - 0.0027 18.0 0.1 0.84 10.0 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Colipase_C PF02740.14 PIK51581.1 - 0.071 13.3 0.4 0.16 12.2 0.4 1.5 1 0 0 1 1 1 0 Colipase, C-terminal domain DUF1180 PF06679.12 PIK51581.1 - 0.15 12.5 0.1 0.15 12.5 0.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1180) C2-set_2 PF08205.12 PIK51581.1 - 0.35 11.0 0.1 0.35 11.0 0.1 3.4 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain UPF0172 PF03665.13 PIK51582.1 - 0.17 11.9 0.0 13 5.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) C2-set_2 PF08205.12 PIK51583.1 - 7.2e-08 32.4 1.3 1.4e-07 31.4 0.3 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK51583.1 - 1.6e-07 31.8 4.4 0.0007 20.1 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK51583.1 - 0.00021 21.3 0.2 0.087 12.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK51583.1 - 0.016 15.3 4.9 4.1 7.6 0.2 3.6 3 1 0 3 3 3 0 Immunoglobulin domain Ig_5 PF16681.5 PIK51583.1 - 0.068 13.6 1.0 0.4 11.1 0.5 2.5 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 PIK51583.1 - 0.4 10.9 4.8 0.73 10.0 0.8 3.2 3 1 0 3 3 3 0 Immunoglobulin V-set domain Ion_trans_2 PF07885.16 PIK51585.1 - 2e-14 53.3 19.1 1.4e-09 37.7 9.2 2.4 2 0 0 2 2 2 2 Ion channel Kazal_2 PF07648.15 PIK51586.1 - 1.4e-15 57.1 12.2 1e-08 35.1 3.7 2.4 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK51586.1 - 1.1e-11 44.6 11.0 1.6e-05 24.8 1.1 2.4 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain BUD22 PF09073.10 PIK51586.1 - 0.16 11.3 10.9 0.24 10.7 10.9 1.2 1 0 0 1 1 1 0 BUD22 Death PF00531.22 PIK51587.1 - 9.2e-09 35.4 0.0 3.5e-08 33.5 0.1 2.0 2 0 0 2 2 2 1 Death domain PDZ_6 PF17820.1 PIK51587.1 - 1e-06 28.5 0.0 2.4e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK51587.1 - 0.0022 18.3 0.0 0.0058 16.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK51587.1 - 0.035 14.5 0.0 0.078 13.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Ank_2 PF12796.7 PIK51588.1 - 1.9e-16 60.4 0.2 1.7e-15 57.3 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK51588.1 - 1.6e-14 54.0 0.5 1.6e-05 25.4 0.0 4.6 2 1 3 5 5 5 3 Ankyrin repeats (many copies) SAM_1 PF00536.30 PIK51588.1 - 1.5e-13 51.0 0.3 3e-13 50.0 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank PF00023.30 PIK51588.1 - 8.2e-12 45.0 0.0 0.0051 17.2 0.0 4.8 4 1 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK51588.1 - 1.5e-10 41.1 0.1 0.00027 21.2 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) SAM_2 PF07647.17 PIK51588.1 - 1e-08 35.1 0.2 3.2e-08 33.6 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_3 PF13606.6 PIK51588.1 - 1.7e-06 27.9 0.0 0.39 11.4 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat SNF PF00209.18 PIK51589.1 - 7.3e-213 708.0 40.4 8.3e-213 707.8 40.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Transketolase_C PF02780.20 PIK51590.1 - 1.1e-25 89.8 0.2 1.6e-25 89.3 0.2 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 PIK51590.1 - 5.4e-09 36.0 0.0 9.5e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 PIK51590.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_N PF00456.21 PIK51591.1 - 8.9e-37 126.8 0.0 1.4e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.20 PIK51591.1 - 2.7e-09 36.4 0.0 3.7e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 PIK51591.1 - 4.5e-06 26.1 0.0 0.00028 20.2 0.0 2.2 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 PIK51591.1 - 2.9e-05 23.1 0.0 5.3e-05 22.2 0.0 1.4 2 0 0 2 2 2 1 XFP N-terminal domain TPP_enzyme_C PF02775.21 PIK51591.1 - 0.00011 22.0 0.1 0.00061 19.6 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CHCH PF06747.13 PIK51592.1 - 7.1e-08 32.4 1.3 1.4e-07 31.4 1.3 1.6 1 0 0 1 1 1 1 CHCH domain CDC45 PF02724.14 PIK51592.1 - 10 4.3 12.3 12 4.0 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Nuc_sug_transp PF04142.15 PIK51593.1 - 1.8e-121 405.1 19.6 2.2e-121 404.9 19.6 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 PIK51593.1 - 0.00015 22.0 29.5 0.0014 18.8 13.4 2.8 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.6 PIK51593.1 - 0.00052 19.7 7.5 0.00052 19.7 7.5 2.2 1 1 1 2 2 2 1 Putative multidrug resistance efflux transporter PUNUT PF16913.5 PIK51593.1 - 0.024 13.9 22.3 0.042 13.1 22.3 1.4 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport DUF3742 PF12553.8 PIK51593.1 - 1.8 8.7 3.7 0.5 10.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) Fibrinogen_C PF00147.18 PIK51594.1 - 1.6e-52 178.5 8.0 2e-52 178.2 8.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain C6 PF01681.17 PIK51594.1 - 0.065 13.8 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 C6 domain Fibrinogen_C PF00147.18 PIK51596.1 - 4.4e-56 190.2 3.3 6.4e-56 189.6 1.8 1.8 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK51596.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lectin_C PF00059.21 PIK51596.1 - 0.13 13.0 0.8 0.56 11.0 0.2 2.2 1 1 1 2 2 2 0 Lectin C-type domain Pkinase_Tyr PF07714.17 PIK51597.1 - 3.4e-17 62.6 0.0 4.4e-11 42.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK51597.1 - 0.051 12.9 0.0 1 8.6 0.0 2.4 1 1 1 2 2 2 0 Protein kinase domain I-set PF07679.16 PIK51597.1 - 0.066 13.3 0.6 1.8 8.7 0.4 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain C1-set PF07654.15 PIK51597.1 - 0.86 10.0 4.2 0.95 9.9 1.9 2.2 2 0 0 2 2 2 0 Immunoglobulin C1-set domain NACHT PF05729.12 PIK51598.1 - 2.7e-10 40.4 0.1 5e-10 39.5 0.1 1.4 1 0 0 1 1 1 1 NACHT domain TMEM154 PF15102.6 PIK51598.1 - 0.0046 16.9 0.2 0.013 15.4 0.2 1.7 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 PIK51598.1 - 0.0085 16.4 0.7 0.022 15.0 0.2 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator OPT PF03169.15 PIK51598.1 - 0.014 14.1 0.0 0.02 13.5 0.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein EphA2_TM PF14575.6 PIK51598.1 - 0.031 15.2 0.0 0.15 12.9 0.0 2.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 PIK51598.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 COX2_TM PF02790.15 PIK51598.1 - 0.22 11.7 1.2 7.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain NS3_envE PF02723.14 PIK51598.1 - 1.3 9.1 5.3 4.4 7.4 5.3 1.8 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Pkinase_Tyr PF07714.17 PIK51599.1 - 1.7e-40 138.9 0.1 2.7e-40 138.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51599.1 - 1.2e-07 31.4 0.0 2e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK51599.1 - 9.6e-07 29.3 2.9 0.008 16.8 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK51599.1 - 0.012 15.7 0.2 3.4 7.8 0.0 3.2 2 1 0 2 2 2 0 Immunoglobulin I-set domain F5_F8_type_C PF00754.25 PIK51600.1 - 1.3e-08 35.0 0.1 1.6e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 F5/8 type C domain DUF4859 PF16151.5 PIK51600.1 - 0.064 13.1 2.1 0.092 12.6 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4859) fn3_4 PF16794.5 PIK51601.1 - 3.3e-26 91.2 0.0 7.2e-26 90.1 0.0 1.6 1 0 0 1 1 1 1 Fibronectin-III type domain EnY2 PF10163.9 PIK51601.1 - 1.3 9.4 7.3 2.5 8.5 2.6 2.9 2 0 0 2 2 2 0 Transcription factor e(y)2 Mito_carr PF00153.27 PIK51602.1 - 9.1e-43 144.1 1.0 3.3e-21 75.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein eIF2A PF08662.11 PIK51603.1 - 1.2e-22 80.8 0.1 1e-21 77.7 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A eIF2A PF08662.11 PIK51604.1 - 4.1e-13 49.6 0.9 2.9e-12 46.9 0.4 2.0 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A RP853 PF17542.2 PIK51604.1 - 0.064 12.4 0.0 0.078 12.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized RP853 Peptidase_S10 PF00450.22 PIK51605.1 - 1.3e-34 120.4 5.2 6.5e-12 45.6 0.1 4.0 2 1 2 4 4 4 4 Serine carboxypeptidase Solute_trans_a PF03619.16 PIK51606.1 - 7.7e-82 274.8 17.2 9.3e-82 274.5 17.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Mito_morph_reg PF14972.6 PIK51607.1 - 4.1e-70 234.6 0.1 4.7e-70 234.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator adh_short PF00106.25 PIK51608.1 - 4.7e-53 179.5 0.5 6e-53 179.2 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK51608.1 - 8.6e-37 126.9 0.2 1e-36 126.6 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK51608.1 - 2.1e-08 34.3 0.1 3.3e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK51608.1 - 0.00031 20.3 0.3 0.0013 18.2 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ApbA PF02558.16 PIK51608.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA LDcluster4 PF18306.1 PIK51608.1 - 0.038 13.6 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 SLOG cluster4 family 2-Hacid_dh_C PF02826.19 PIK51608.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 5TM-5TMR_LYT PF07694.12 PIK51608.1 - 0.15 11.6 1.3 0.83 9.1 0.2 2.1 2 0 0 2 2 2 0 5TMR of 5TMR-LYT UCH PF00443.29 PIK51609.1 - 4.9e-35 121.3 0.0 6e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK51609.1 - 5e-13 49.3 0.2 1.2e-11 44.8 0.2 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Olduvai PF06758.13 PIK51609.1 - 0.1 12.8 2.4 0.35 11.2 2.4 1.9 1 0 0 1 1 1 0 Olduvai domain UQ_con PF00179.26 PIK51610.1 - 7.5e-25 87.2 0.0 1.5e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK51610.1 - 0.023 14.6 0.0 0.078 12.8 0.0 1.8 1 1 1 2 2 2 0 UEV domain ACR_tran PF00873.19 PIK51610.1 - 0.055 11.1 7.2 0.63 7.6 4.8 2.1 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family DUF4702 PF15774.5 PIK51611.1 - 0.025 13.6 0.8 0.035 13.1 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) Emaravirus_P4 PF16505.5 PIK51611.1 - 0.17 10.9 0.5 0.27 10.2 0.5 1.2 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily Glycoprotein_G PF00802.19 PIK51612.1 - 0.24 10.7 5.4 0.44 9.9 5.4 1.3 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G TAXi_N PF14543.6 PIK51612.1 - 0.39 10.9 2.9 0.35 11.1 0.6 1.8 2 0 0 2 2 2 0 Xylanase inhibitor N-terminal 7tm_1 PF00001.21 PIK51613.1 - 3.9e-26 92.0 11.2 5.2e-26 91.5 11.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK51613.1 - 7.7e-08 32.3 11.5 7.7e-08 32.3 11.5 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK51613.1 - 2.2e-06 27.2 1.8 2.2e-06 27.2 1.8 2.6 2 1 1 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srw Serpentine_r_xa PF03383.15 PIK51613.1 - 0.0002 21.3 2.1 0.0002 21.3 2.1 2.3 1 1 1 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa 7tm_1 PF00001.21 PIK51614.1 - 2.1e-24 86.3 12.3 3.1e-24 85.7 12.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK51614.1 - 2.4e-08 33.9 6.8 2.4e-08 33.9 6.8 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 PIK51614.1 - 0.00019 21.5 0.7 0.00019 21.5 0.7 2.1 2 0 0 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srw PF10324.9 PIK51614.1 - 0.0023 17.3 17.4 0.037 13.3 7.4 2.5 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw Peptidase_M41 PF01434.18 PIK51614.1 - 0.18 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M41 2OG-FeII_Oxy_2 PF13532.6 PIK51615.1 - 3.8e-11 43.6 0.0 5.7e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ECH_1 PF00378.20 PIK51616.1 - 5e-90 301.2 0.3 6.8e-90 300.8 0.3 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK51616.1 - 1.3e-34 120.2 1.4 3.3e-31 109.0 0.3 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK51616.1 - 0.1 12.6 0.3 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 Acetyltransf_3 PF13302.7 PIK51617.1 - 1.7e-21 77.4 0.0 2.1e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 PIK51617.1 - 2.4e-08 34.2 0.0 3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 PIK51617.1 - 4.6e-07 29.7 0.0 7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 PIK51617.1 - 9e-06 25.9 0.3 3.1e-05 24.2 0.3 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 PIK51617.1 - 9.6e-06 25.3 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK51617.1 - 0.0026 18.1 0.0 0.0037 17.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 PIK51617.1 - 0.015 15.2 0.0 0.022 14.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RNase_PH_C PF03725.15 PIK51617.1 - 0.028 14.4 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 PH PF00169.29 PIK51618.1 - 5.7e-26 91.1 0.0 1.1e-11 45.2 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 PIK51618.1 - 7.5e-10 39.2 0.3 2e-06 28.1 0.0 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 PIK51618.1 - 1.5e-08 34.8 2.0 0.0063 16.8 0.1 3.3 3 1 0 3 3 3 2 Pleckstrin homology domain PH_16 PF17838.1 PIK51618.1 - 0.002 18.0 0.0 0.2 11.5 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 PIK51618.1 - 0.008 16.0 0.2 0.078 12.8 0.1 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain Mvb12 PF09452.10 PIK51618.1 - 0.06 13.8 0.3 3.1 8.3 0.0 2.9 3 1 1 4 4 4 0 ESCRT-I subunit Mvb12 NOT2_3_5 PF04153.18 PIK51620.1 - 2.3e-35 121.5 11.0 2.5e-35 121.4 11.0 1.0 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Not3 PF04065.15 PIK51622.1 - 4.4e-75 252.1 20.2 4.4e-75 252.1 20.2 1.7 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component PulA_N1 PF17999.1 PIK51622.1 - 0.051 14.3 0.5 0.051 14.3 0.5 2.5 2 1 1 3 3 3 0 Pullulanase N1-terminal domain IQ PF00612.27 PIK51623.1 - 0.0024 17.5 0.0 0.0052 16.5 0.0 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF1474 PF07342.11 PIK51624.1 - 0.016 15.8 5.5 0.5 10.9 1.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1474) ZnuA PF01297.17 PIK51624.1 - 8.3 5.7 11.2 0.29 10.5 0.1 3.1 1 1 0 3 3 3 0 Zinc-uptake complex component A periplasmic GLE1 PF07817.13 PIK51625.1 - 1.2 8.3 6.5 4.7 6.4 5.8 2.2 1 1 0 1 1 1 0 GLE1-like protein DUF573 PF04504.14 PIK51625.1 - 3.6 8.3 17.9 4.9 7.9 3.3 3.6 2 1 0 2 2 2 0 Protein of unknown function, DUF573 PIN_8 PF18476.1 PIK51625.1 - 9.5 6.0 31.4 4.1 7.2 11.6 2.6 1 1 2 3 3 3 0 PIN like domain Hid1 PF12722.7 PIK51626.1 - 1.1e-41 143.0 0.4 1.2e-41 142.7 0.4 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 PIK51626.1 - 7.2e-35 120.5 0.0 7.2e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein ANTH PF07651.16 PIK51626.1 - 0.11 11.4 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 ANTH domain TMEM171 PF15471.6 PIK51626.1 - 0.21 10.6 2.5 0.29 10.1 2.5 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 RAP1 PF07218.11 PIK51626.1 - 0.23 9.7 0.5 0.24 9.7 0.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hid1 PF12722.7 PIK51627.1 - 1.3e-110 370.9 0.1 4.6e-70 236.8 0.1 2.0 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 PIK51627.1 - 8.6e-105 351.5 6.6 9.4e-67 225.8 0.1 2.0 1 1 1 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 PIK51628.1 - 3.7e-35 121.3 0.0 4.6e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 PIK51628.1 - 5.3e-27 94.5 0.0 6e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Orbi_VP1 PF05788.12 PIK51628.1 - 0.12 9.9 0.0 0.14 9.7 0.0 1.0 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) Cyclin_N PF00134.23 PIK51629.1 - 1.6e-30 105.5 0.8 1.4e-27 95.9 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK51629.1 - 1.7e-18 66.8 1.0 6.8e-18 64.9 0.7 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain F-box-like PF12937.7 PIK51629.1 - 1.2e-10 41.1 0.2 6.7e-09 35.5 0.0 3.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 PIK51629.1 - 1.4e-05 24.8 0.1 8.9e-05 22.3 0.0 2.3 2 0 0 2 2 2 1 F-box domain Sel1 PF08238.12 PIK51629.1 - 0.029 15.1 1.3 4.9 8.0 0.4 2.5 2 0 0 2 2 2 0 Sel1 repeat Phg_2220_C PF09524.10 PIK51629.1 - 0.19 11.8 0.4 0.64 10.1 0.1 2.1 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) Promethin PF16015.5 PIK51630.1 - 1.2e-14 54.1 15.5 1.9e-14 53.4 15.5 1.3 1 0 0 1 1 1 1 Promethin DUF2207 PF09972.9 PIK51630.1 - 0.26 10.0 2.8 0.33 9.7 2.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CUB PF00431.20 PIK51632.1 - 1.3e-19 70.5 0.0 1.9e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 CUB domain EGF PF00008.27 PIK51632.1 - 1.4e-05 25.3 6.9 2.6e-05 24.4 6.9 1.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK51632.1 - 0.00017 22.1 7.9 0.00036 21.0 7.9 1.6 1 0 0 1 1 1 1 Human growth factor-like EGF ComK PF06338.11 PIK51632.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 ComK protein EGF_2 PF07974.13 PIK51632.1 - 0.091 13.1 8.2 0.18 12.2 8.2 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_CA PF07645.15 PIK51632.1 - 0.27 11.5 8.5 0.44 10.8 8.5 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain cEGF PF12662.7 PIK51632.1 - 4.4 7.3 8.4 2.1 8.3 3.7 2.3 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF PF00008.27 PIK51633.1 - 1.4e-53 178.7 97.0 1.4e-08 34.8 5.9 8.3 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK51633.1 - 6.1e-35 118.7 100.2 7.4e-06 26.4 8.6 9.6 10 0 0 10 10 10 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK51633.1 - 3.4e-31 107.2 120.9 9.9e-06 25.7 7.9 8.1 8 0 0 8 8 8 8 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51633.1 - 3.4e-18 65.7 116.8 0.004 17.5 10.1 8.3 8 0 0 8 8 8 8 EGF-like domain EGF_3 PF12947.7 PIK51633.1 - 2.1e-09 37.4 100.0 0.0091 16.2 6.2 8.9 8 2 0 8 8 8 7 EGF domain cEGF PF12662.7 PIK51633.1 - 5.9e-09 35.7 78.7 0.003 17.4 5.6 9.8 8 3 0 8 8 8 7 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK51633.1 - 0.00014 22.1 90.9 0.29 11.4 5.3 8.6 4 2 4 8 8 8 4 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 PIK51633.1 - 0.0052 16.9 97.8 0.51 10.5 5.9 8.3 3 1 5 8 8 8 4 Laminin EGF domain EGF PF00008.27 PIK51634.1 - 2.8e-22 78.7 35.2 2.6e-09 37.2 5.4 3.2 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK51634.1 - 3.1e-16 59.3 35.8 5.7e-08 33.1 4.6 3.8 3 0 0 3 3 3 3 Human growth factor-like EGF EGF_CA PF07645.15 PIK51634.1 - 4.8e-10 39.5 46.0 4e-06 26.9 9.2 3.2 2 1 1 3 3 3 2 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51634.1 - 5.9e-07 29.8 47.4 0.0072 16.7 13.5 3.2 3 0 0 3 3 3 3 EGF-like domain FXa_inhibition PF14670.6 PIK51634.1 - 0.00031 21.0 28.9 0.0082 16.4 3.4 3.5 1 1 2 3 3 3 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK51634.1 - 0.022 14.7 23.5 0.27 11.2 0.9 4.9 4 2 0 4 4 4 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK51634.1 - 0.29 11.3 34.1 0.93 9.7 7.8 3.3 2 1 1 3 3 3 0 Laminin EGF domain EGF_3 PF12947.7 PIK51634.1 - 0.32 11.2 39.0 0.32 11.2 3.0 3.7 3 1 0 3 3 3 0 EGF domain EGF PF00008.27 PIK51635.1 - 1.7e-41 140.1 62.5 8.7e-11 41.9 4.8 5.3 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.7 PIK51635.1 - 1.4e-28 98.5 65.4 9.6e-08 32.4 6.3 6.8 7 0 0 7 7 7 5 Human growth factor-like EGF EGF_CA PF07645.15 PIK51635.1 - 2.9e-09 37.0 73.3 0.0005 20.2 8.1 5.6 2 2 3 5 5 5 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51635.1 - 3.8e-09 36.7 77.8 0.003 17.9 9.8 5.4 5 0 0 5 5 5 4 EGF-like domain FXa_inhibition PF14670.6 PIK51635.1 - 0.0028 17.9 57.3 0.27 11.5 5.9 5.5 2 2 3 5 5 5 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK51635.1 - 0.078 13.2 64.2 0.29 11.4 3.0 6.3 4 2 1 5 5 5 0 EGF domain EGF PF00008.27 PIK51636.1 - 1.3e-50 169.2 112.7 3.2e-10 40.1 5.9 8.4 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 PIK51636.1 - 1.6e-30 104.7 106.3 2.1e-06 28.1 8.4 9.6 8 1 1 9 9 9 8 Human growth factor-like EGF EGF_CA PF07645.15 PIK51636.1 - 1.3e-18 66.9 122.2 0.00044 20.4 11.1 8.3 7 1 1 8 8 8 8 Calcium-binding EGF domain EGF_2 PF07974.13 PIK51636.1 - 5.2e-18 65.1 132.5 0.0016 18.8 13.3 8.4 8 0 0 8 8 8 8 EGF-like domain CUB PF00431.20 PIK51636.1 - 1.9e-14 53.9 0.0 4.1e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 CUB domain FXa_inhibition PF14670.6 PIK51636.1 - 0.00072 19.8 88.7 0.13 12.6 4.4 8.3 3 3 4 7 7 7 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK51636.1 - 0.014 15.3 70.9 0.35 10.8 2.0 8.5 7 0 0 7 7 7 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK51636.1 - 1.7 8.8 93.8 1.9 8.7 4.6 7.6 3 3 4 7 7 7 0 Laminin EGF domain rve PF00665.26 PIK51637.1 - 6.4e-24 84.4 0.0 1.2e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK51637.1 - 1.5e-08 34.3 0.0 4.6e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 PIK51637.1 - 0.0033 17.5 0.0 0.0083 16.2 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RGS PF00615.19 PIK51638.1 - 1.1e-18 67.6 0.0 7.1e-12 45.6 0.0 2.0 2 0 0 2 2 2 2 Regulator of G protein signaling domain Tubulin PF00091.25 PIK51639.1 - 4.8e-50 170.5 0.1 6.2e-50 170.1 0.1 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 PIK51639.1 - 0.19 10.8 0.5 0.47 9.6 0.4 1.7 1 1 0 1 1 1 0 Tubulin like Phospholip_B PF04916.13 PIK51640.1 - 3.3e-162 540.8 4.6 4e-162 540.5 4.6 1.0 1 0 0 1 1 1 1 Phospholipase B Hydrolase PF00702.26 PIK51641.1 - 2.6e-13 50.7 0.0 3.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 PIK51641.1 - 2.2e-08 34.7 0.0 3.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 PIK51641.1 - 0.0017 17.8 0.1 0.0034 16.8 0.1 1.4 1 1 0 1 1 1 1 Putative Phosphatase Acid_phosphat_B PF03767.14 PIK51641.1 - 0.0054 16.3 0.4 0.13 11.8 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Hrs_helical PF12210.8 PIK51641.1 - 0.012 16.1 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate UMPH-1 PF05822.12 PIK51641.1 - 0.013 15.0 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.6 PIK51641.1 - 0.056 13.5 0.1 14 5.7 0.0 2.5 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase MMR_HSR1 PF01926.23 PIK51642.1 - 2.5e-19 69.4 0.0 4.5e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK51642.1 - 1.4e-07 31.2 0.0 2.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK51642.1 - 1e-06 28.9 2.5 0.0016 18.5 0.3 2.6 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 PIK51642.1 - 7.1e-05 22.2 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 PIK51642.1 - 0.0004 20.0 0.1 0.088 12.3 0.1 2.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK51642.1 - 0.00094 19.1 1.3 0.0089 15.9 0.2 2.2 1 1 1 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 PIK51642.1 - 0.15 12.3 0.1 1.5 9.0 0.1 2.5 2 1 1 3 3 3 0 AAA domain CLAMP PF14769.6 PIK51643.1 - 2.7e-37 127.2 1.9 4.5e-37 126.5 1.9 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 Rad51 PF08423.11 PIK51644.1 - 7.3e-33 113.9 0.6 1e-31 110.1 0.3 2.5 1 1 1 2 2 2 1 Rad51 AAA_25 PF13481.6 PIK51644.1 - 2.6e-09 36.9 0.0 6.1e-09 35.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK51644.1 - 2.1e-08 33.8 0.0 4.8e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 KaiC RecA PF00154.21 PIK51644.1 - 0.00017 21.1 0.0 0.00057 19.4 0.0 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 PIK51644.1 - 0.002 17.5 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 PIK51644.1 - 0.003 17.3 0.0 0.0073 16.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK51644.1 - 0.021 15.1 0.4 0.078 13.2 0.4 1.8 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 PIK51644.1 - 0.036 14.2 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mito_carr PF00153.27 PIK51645.1 - 2.6e-63 210.0 0.2 7e-22 77.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tektin PF03148.14 PIK51646.1 - 1.8e-146 487.8 36.0 2e-146 487.7 36.0 1.0 1 0 0 1 1 1 1 Tektin family Filament PF00038.21 PIK51646.1 - 0.0072 15.9 8.6 0.0072 15.9 8.6 2.7 2 1 0 2 2 2 1 Intermediate filament protein Snapin_Pallidin PF14712.6 PIK51646.1 - 0.11 13.0 21.0 1.8 9.1 0.0 5.6 4 1 2 6 6 6 0 Snapin/Pallidin ATP-synt_F6 PF05511.11 PIK51646.1 - 0.23 11.9 5.8 1.3 9.5 0.3 3.2 3 0 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 DASH_Dam1 PF08653.10 PIK51646.1 - 0.24 11.2 1.4 21 5.0 0.1 3.4 3 0 0 3 3 3 0 DASH complex subunit Dam1 YojJ PF10372.9 PIK51646.1 - 0.55 10.4 7.3 0.15 12.2 0.4 3.5 3 1 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus Syntaxin_2 PF14523.6 PIK51646.1 - 0.62 10.5 19.7 0.6 10.5 0.7 4.0 3 1 1 4 4 4 0 Syntaxin-like protein Nsp1_C PF05064.13 PIK51646.1 - 0.69 9.7 16.5 0.19 11.5 0.2 3.7 4 0 0 4 4 4 0 Nsp1-like C-terminal region DUF948 PF06103.11 PIK51646.1 - 0.83 9.9 18.7 4.3 7.6 0.4 4.7 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) CelTOS PF18659.1 PIK51646.1 - 2.3 8.6 10.5 0.31 11.5 0.6 3.4 2 2 1 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites DUF1664 PF07889.12 PIK51646.1 - 2.5 8.1 20.1 0.32 11.0 1.4 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 PIK51646.1 - 3.9 7.0 21.0 0.32 10.5 1.3 4.1 2 2 1 4 4 4 0 fzo-like conserved region Trimer_CC PF08954.11 PIK51646.1 - 5.8 6.6 13.3 0.17 11.5 0.4 3.5 4 0 0 4 4 4 0 Trimerisation motif Exonuc_VII_L PF02601.15 PIK51646.1 - 6.3 6.3 17.8 3.6 7.0 3.6 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF155 PF02582.14 PIK51647.1 - 3.2e-48 164.2 1.4 4.5e-48 163.7 1.4 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Metallophos PF00149.28 PIK51648.1 - 2.7e-37 129.3 0.2 3.7e-37 128.8 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK51648.1 - 0.0003 21.2 0.7 0.0008 19.8 0.7 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain zf-B_box PF00643.24 PIK51649.1 - 1.2e-08 34.9 9.6 1.2e-08 34.9 9.6 3.2 2 1 1 3 3 3 1 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK51649.1 - 0.00014 21.7 15.4 0.00014 21.7 15.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) MATH PF00917.26 PIK51649.1 - 0.00036 20.7 0.1 0.0042 17.2 0.0 2.3 2 0 0 2 2 2 1 MATH domain HlyD_2 PF12700.7 PIK51649.1 - 0.0022 16.8 8.5 0.0032 16.3 8.5 1.2 1 0 0 1 1 1 1 HlyD family secretion protein Spc29 PF17082.5 PIK51649.1 - 0.008 16.0 2.8 0.012 15.5 2.8 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 zf-C3HC4_2 PF13923.6 PIK51649.1 - 0.0085 15.9 16.0 0.0085 15.9 16.0 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) CobN-Mg_chel PF02514.16 PIK51649.1 - 0.13 10.0 1.1 0.17 9.6 1.1 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase HSCB_C PF07743.13 PIK51649.1 - 0.46 11.0 6.0 0.46 11.0 0.9 2.7 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain DUF1479 PF07350.12 PIK51649.1 - 0.5 9.1 3.2 4.1 6.1 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) DUF1664 PF07889.12 PIK51649.1 - 3 7.9 9.8 0.79 9.8 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 PIK51649.1 - 3.6 6.1 7.5 5 5.6 7.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Siva PF05458.12 PIK51649.1 - 6 6.5 18.4 4.8 6.8 9.0 2.3 2 0 0 2 2 2 0 Cd27 binding protein (Siva) SR-25 PF10500.9 PIK51650.1 - 0.45 10.1 11.8 0.7 9.5 11.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 PIK51650.1 - 3 7.5 8.7 3.7 7.2 8.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Macoilin PF09726.9 PIK51650.1 - 4.8 5.6 7.6 5.7 5.4 7.6 1.1 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 PIK51650.1 - 9.5 4.2 16.7 9.9 4.1 16.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein I_LWEQ PF01608.17 PIK51652.1 - 2.8e-52 177.0 8.8 2.8e-52 177.0 8.8 3.7 3 1 1 4 4 4 1 I/LWEQ domain ANTH PF07651.16 PIK51652.1 - 6.2e-23 81.2 0.0 6.2e-23 81.2 0.0 2.9 3 0 0 3 3 3 1 ANTH domain HIP1_clath_bdg PF16515.5 PIK51652.1 - 7e-05 23.4 4.7 7e-05 23.4 4.7 4.6 4 1 1 5 5 5 2 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF484 PF04340.12 PIK51652.1 - 1.2 8.8 13.3 0.47 10.1 8.7 2.6 2 1 1 3 3 3 0 Protein of unknown function, DUF484 CRAL_TRIO PF00650.20 PIK51653.1 - 5.5e-35 120.4 0.0 7.6e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 PIK51653.1 - 1.9e-08 34.9 0.4 0.00048 20.6 0.0 2.4 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.6 PIK51653.1 - 0.049 13.8 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Sec1 PF00995.23 PIK51654.1 - 3.4e-98 330.3 0.6 6.7e-83 279.9 0.1 2.0 1 1 1 2 2 2 2 Sec1 family Peptidase_C1_2 PF03051.15 PIK51655.1 - 2.9e-163 543.7 1.9 5.7e-147 490.0 0.1 2.0 1 1 1 2 2 2 2 Peptidase C1-like family OST3_OST6 PF04756.13 PIK51656.1 - 9.5e-05 21.9 0.3 0.00015 21.2 0.3 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family PALP PF00291.25 PIK51657.1 - 5.3e-71 239.4 0.8 6.1e-71 239.2 0.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CHAT PF12770.7 PIK51657.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 CHAT domain FAD_binding_2 PF00890.24 PIK51657.1 - 0.025 13.6 0.2 0.043 12.9 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 PIK51657.1 - 0.045 13.0 0.1 0.085 12.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AMP-binding PF00501.28 PIK51657.1 - 0.12 10.9 0.0 0.33 9.5 0.0 1.6 2 0 0 2 2 2 0 AMP-binding enzyme DAGK_cat PF00781.24 PIK51657.1 - 0.12 12.0 0.1 0.3 10.7 0.1 1.7 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain HPIP PF15226.6 PIK51658.1 - 0.0019 18.6 0.5 0.0043 17.5 0.5 1.6 1 0 0 1 1 1 1 HCF-1 beta-propeller-interacting protein family MOZART2 PF12926.7 PIK51659.1 - 4.2e-22 77.5 0.1 5.4e-22 77.2 0.1 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated MOZART1 PF12554.8 PIK51659.1 - 0.09 12.6 0.5 0.13 12.1 0.5 1.2 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated DUF1456 PF07308.13 PIK51659.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1456) PH PF00169.29 PIK51660.1 - 5e-10 39.8 1.4 7e-10 39.4 0.1 1.9 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 PIK51660.1 - 1.2e-08 35.1 0.1 1.9e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 PIK51660.1 - 8.7e-06 26.1 4.3 0.048 14.1 0.1 2.5 1 1 0 2 2 2 2 Pleckstrin homology domain Nop16 PF09420.10 PIK51660.1 - 0.0011 19.1 0.6 0.0015 18.6 0.6 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Tropomyosin PF00261.20 PIK51660.1 - 0.0029 17.0 5.1 0.0036 16.7 5.1 1.1 1 0 0 1 1 1 1 Tropomyosin PH_6 PF15406.6 PIK51660.1 - 0.02 15.2 0.0 0.045 14.0 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF1758 PF05585.12 PIK51660.1 - 0.024 14.4 0.1 0.028 14.2 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF1758) DUF577 PF04510.12 PIK51660.1 - 0.043 13.7 0.8 0.11 12.4 0.8 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF577) DUF3450 PF11932.8 PIK51660.1 - 0.059 12.7 3.0 0.081 12.2 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF5401 PF17380.2 PIK51660.1 - 0.063 11.3 2.6 0.074 11.1 2.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) vATP-synt_E PF01991.18 PIK51660.1 - 0.2 11.1 5.2 0.27 10.6 5.2 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit RVT_1 PF00078.27 PIK51661.1 - 0.0015 18.1 0.0 0.0018 17.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MtrG PF04210.13 PIK51665.1 - 0.0072 16.2 4.9 0.66 9.9 0.3 3.8 2 2 2 4 4 4 1 Tetrahydromethanopterin S-methyltransferase, subunit G Baculo_PEP_C PF04513.12 PIK51665.1 - 0.01 15.9 0.1 0.025 14.6 0.1 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Alpha-2-MRAP_C PF06401.11 PIK51665.1 - 0.011 15.7 0.8 0.014 15.4 0.8 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF922 PF06037.11 PIK51665.1 - 0.019 14.7 0.2 0.036 13.8 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Med9 PF07544.13 PIK51665.1 - 0.035 14.2 4.7 0.29 11.2 0.5 2.9 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Occludin_ELL PF07303.13 PIK51665.1 - 0.042 14.6 0.7 0.071 13.8 0.7 1.5 1 0 0 1 1 1 0 Occludin homology domain NPV_P10 PF05531.12 PIK51665.1 - 0.043 14.3 0.7 2.9 8.4 0.3 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 PIK51665.1 - 0.05 13.9 2.8 0.19 12.0 1.1 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 PIK51665.1 - 0.053 13.6 2.3 0.27 11.3 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 PIK51665.1 - 0.054 13.9 8.1 0.11 13.0 3.9 2.9 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 PIK51665.1 - 0.063 13.5 6.7 0.052 13.8 2.3 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF16 PF01519.16 PIK51665.1 - 0.063 13.8 4.0 0.13 12.7 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Spc7 PF08317.11 PIK51665.1 - 0.096 11.6 4.5 0.13 11.1 4.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 PIK51665.1 - 0.12 13.1 3.0 0.24 12.0 3.0 1.7 1 1 0 1 1 1 0 Initiation control protein YabA Fez1 PF06818.15 PIK51665.1 - 0.13 12.7 4.2 0.22 12.0 1.3 2.1 2 0 0 2 2 2 0 Fez1 DUF2730 PF10805.8 PIK51665.1 - 0.4 10.8 2.7 1.6 8.9 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Ig_3 PF13927.6 PIK51666.1 - 0.002 18.7 6.3 0.35 11.5 0.0 4.0 2 1 1 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK51667.1 - 8.6e-08 32.7 0.0 1.2e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK51667.1 - 3.2e-07 30.3 0.0 4.8e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK51667.1 - 5.8e-07 29.6 0.0 1e-06 28.8 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK51667.1 - 0.0018 18.4 0.0 0.0032 17.6 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK51667.1 - 0.0098 16.2 0.1 0.033 14.5 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK51667.1 - 0.15 11.7 0.1 0.35 10.5 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK51668.1 - 3.3e-46 157.7 0.0 4.2e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51668.1 - 9.8e-19 67.7 0.0 1.5e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF810 PF05664.11 PIK51668.1 - 0.059 11.9 0.0 0.078 11.5 0.0 1.1 1 0 0 1 1 1 0 Plant family of unknown function (DUF810) Pkinase_Tyr PF07714.17 PIK51669.1 - 7e-27 94.3 0.0 9.8e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51669.1 - 7.2e-11 42.0 0.0 1.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF4834 PF16118.5 PIK51669.1 - 0.052 14.5 0.2 0.098 13.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) WBP-1 PF11669.8 PIK51669.1 - 0.069 13.8 0.0 0.35 11.5 0.0 2.0 2 0 0 2 2 2 0 WW domain-binding protein 1 Ig_3 PF13927.6 PIK51670.1 - 2.3e-09 37.7 0.1 5.4e-05 23.7 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK51670.1 - 8e-07 29.2 0.1 0.0026 17.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK51670.1 - 2.2e-06 27.8 0.0 2.4e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK51670.1 - 5.6e-06 26.6 0.3 0.0088 16.4 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin domain Marek_A PF02124.15 PIK51670.1 - 2.8e-05 24.1 0.1 4.7e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A I-set PF07679.16 PIK51670.1 - 0.00029 20.8 0.1 0.0017 18.4 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin I-set domain DUF747 PF05346.11 PIK51670.1 - 0.0042 16.6 0.1 0.0062 16.0 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family IgaA PF07095.11 PIK51670.1 - 0.051 11.6 0.6 0.068 11.1 0.6 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA SCFA_trans PF02667.14 PIK51670.1 - 0.068 12.2 0.4 0.1 11.5 0.4 1.2 1 0 0 1 1 1 0 Short chain fatty acid transporter Izumo-Ig PF16706.5 PIK51670.1 - 0.078 13.1 0.0 0.47 10.6 0.0 2.3 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain DUF2207 PF09972.9 PIK51670.1 - 0.084 11.6 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ig_6 PF18452.1 PIK51670.1 - 0.12 11.9 0.0 0.34 10.5 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DUF3377 PF11857.8 PIK51670.1 - 0.15 12.0 2.2 0.33 10.9 2.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4381 PF14316.6 PIK51670.1 - 0.16 12.2 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2500 PF10694.9 PIK51670.1 - 0.17 12.4 0.6 1.7 9.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) DUF4446 PF14584.6 PIK51670.1 - 0.22 11.5 3.5 0.15 12.1 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Pkinase_Tyr PF07714.17 PIK51671.1 - 9.9e-21 74.2 0.1 6e-16 58.5 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Ig_3 PF13927.6 PIK51671.1 - 1.2e-10 41.8 3.0 0.00038 21.0 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Pkinase PF00069.25 PIK51671.1 - 1.6e-07 31.0 0.1 5.8e-07 29.1 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain I-set PF07679.16 PIK51671.1 - 6.3e-07 29.4 0.5 0.031 14.4 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK51671.1 - 1.2e-06 28.7 1.0 0.0015 18.8 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK51671.1 - 5e-06 26.6 0.8 0.00078 19.6 0.0 2.9 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK51671.1 - 3.4e-05 24.0 0.6 0.0037 17.4 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ribosomal_L18p PF00861.22 PIK51671.1 - 0.0037 17.6 0.0 0.0074 16.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Izumo-Ig PF16706.5 PIK51671.1 - 0.082 13.0 0.1 0.77 9.9 0.0 2.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Ig_3 PF13927.6 PIK51672.1 - 3.4e-15 56.4 1.1 1.6e-09 38.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK51672.1 - 1.5e-14 53.9 1.6 2.3e-08 34.1 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK51672.1 - 1.3e-12 47.6 0.1 1.5e-08 34.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK51672.1 - 3.3e-12 46.6 1.0 8.9e-06 26.0 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK51672.1 - 8.9e-10 38.7 0.2 3.7e-08 33.5 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK51672.1 - 0.00028 21.2 0.1 0.0086 16.4 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK51672.1 - 0.0096 15.5 0.0 0.027 14.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain DUF1522 PF07482.11 PIK51672.1 - 0.012 15.9 0.1 0.89 9.9 0.0 2.4 1 1 0 2 2 2 0 Domain of Unknown Function (DUF1522) C2-set_2 PF08205.12 PIK51672.1 - 0.049 13.7 0.9 0.1 12.7 0.9 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 PIK51672.1 - 0.051 13.8 0.2 3.9 7.8 0.0 2.8 2 1 1 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_3 PF13927.6 PIK51673.1 - 9.3e-08 32.6 2.0 0.00085 19.9 0.0 3.3 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK51673.1 - 0.00039 20.6 0.5 0.13 12.4 0.1 3.2 2 1 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK51673.1 - 0.00074 19.6 0.4 0.015 15.5 0.1 2.8 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK51673.1 - 0.00075 19.5 0.1 0.027 14.5 0.0 2.9 3 1 0 3 3 3 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK51673.1 - 0.047 14.0 4.4 8.5 6.8 0.0 3.5 1 1 1 3 3 3 0 Immunoglobulin domain Microtub_bd PF16796.5 PIK51674.1 - 0.0028 17.6 0.2 0.016 15.1 0.0 2.0 1 1 1 2 2 2 1 Microtubule binding MG4 PF17789.1 PIK51674.1 - 0.067 13.3 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG4 Ribosomal_L31e PF01198.19 PIK51674.1 - 0.078 13.2 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L31e Arfaptin PF06456.13 PIK51675.1 - 0.14 11.7 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 Arfaptin-like domain DUF2462 PF09495.10 PIK51677.1 - 3.6e-16 59.6 16.2 4.9e-16 59.2 16.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Glycoprot_B_PH2 PF17417.2 PIK51677.1 - 0.059 13.7 0.1 0.077 13.3 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B PH-like domain G-patch PF01585.23 PIK51678.1 - 8e-10 38.5 2.5 1.5e-09 37.5 2.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK51678.1 - 0.024 14.7 1.8 0.064 13.4 1.8 1.8 1 0 0 1 1 1 0 G-patch domain Dimer_Tnp_hAT PF05699.14 PIK51679.1 - 0.00017 21.3 0.0 0.00045 20.0 0.0 1.7 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region PNMA PF14893.6 PIK51680.1 - 0.16 11.4 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 PNMA PNMA PF14893.6 PIK51681.1 - 8e-09 35.3 0.0 8.5e-09 35.3 0.0 1.0 1 0 0 1 1 1 1 PNMA Dimer_Tnp_hAT PF05699.14 PIK51682.1 - 1.7e-17 63.0 0.0 2.5e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.6 PIK51682.1 - 0.023 15.1 0.0 0.034 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) Wyosine_form PF08608.12 PIK51683.1 - 2.1e-28 98.5 0.0 4.8e-28 97.3 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 PIK51683.1 - 5.8e-26 91.8 0.0 1.4e-25 90.6 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 PIK51683.1 - 4.8e-23 81.9 0.1 1.7e-22 80.1 0.1 2.0 1 1 0 1 1 1 1 Flavodoxin DUF1796 PF08795.10 PIK51683.1 - 0.1 12.5 0.0 2.6 8.0 0.0 2.6 2 1 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) Transketolase_C PF02780.20 PIK51683.1 - 0.17 11.7 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain PhnA_Zn_Ribbon PF08274.12 PIK51684.1 - 4.7e-05 23.2 0.2 0.35 10.8 0.0 2.6 2 0 0 2 2 2 2 PhnA Zinc-Ribbon RVT_1 PF00078.27 PIK51684.1 - 0.00015 21.3 0.1 0.00025 20.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2197 PF09963.9 PIK51684.1 - 0.00071 19.8 1.4 0.24 11.7 0.1 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2197) TFIIS_C PF01096.18 PIK51684.1 - 0.0053 16.6 8.9 0.46 10.4 1.6 2.7 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) zf_C2H2_13 PF18508.1 PIK51684.1 - 0.073 12.7 2.1 7.3 6.3 0.1 2.7 2 0 0 2 2 2 0 Zinc finger domain CGGC PF08821.11 PIK51684.1 - 0.093 12.9 7.7 0.25 11.6 0.3 2.2 1 1 1 2 2 2 0 CGGC domain Gin PF10764.9 PIK51684.1 - 0.56 10.2 4.8 7.7 6.6 1.8 2.5 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin PolC_DP2 PF03833.13 PIK51684.1 - 0.69 7.7 2.6 0.39 8.5 0.9 1.3 1 1 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-C2H2_4 PF13894.6 PIK51684.1 - 1.8 9.6 10.2 5.8 8.0 3.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_primase_lrg PF04104.14 PIK51685.1 - 1.5e-30 106.6 0.1 2.3e-30 105.9 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Tenui_NCP PF04876.12 PIK51685.1 - 0.0037 16.9 0.0 0.007 16.0 0.0 1.4 1 0 0 1 1 1 1 Tenuivirus major non-capsid protein VWC PF00093.18 PIK51688.1 - 8.1e-10 38.9 15.0 8.1e-10 38.9 15.0 2.6 2 0 0 2 2 2 1 von Willebrand factor type C domain Amnionless PF14828.6 PIK51688.1 - 1.9e-05 23.7 9.2 3.2e-05 23.0 9.2 1.2 1 0 0 1 1 1 1 Amnionless TILa PF12714.7 PIK51688.1 - 0.012 15.6 9.9 0.012 15.6 9.9 2.1 2 0 0 2 2 2 0 TILa domain CFC PF09443.10 PIK51688.1 - 0.038 13.8 5.5 0.2 11.5 5.5 2.3 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) Amnionless PF14828.6 PIK51689.1 - 0.026 13.4 5.6 0.042 12.7 5.6 1.2 1 0 0 1 1 1 0 Amnionless VWC PF00093.18 PIK51689.1 - 0.54 10.6 10.9 0.51 10.7 7.2 2.5 2 0 0 2 2 2 0 von Willebrand factor type C domain VWC PF00093.18 PIK51691.1 - 1.8e-10 41.0 13.7 1.8e-10 41.0 13.7 2.7 3 0 0 3 3 3 1 von Willebrand factor type C domain Amnionless PF14828.6 PIK51691.1 - 3.2e-06 26.2 3.6 4.8e-06 25.7 3.6 1.2 1 0 0 1 1 1 1 Amnionless CFC PF09443.10 PIK51691.1 - 0.0051 16.6 0.9 0.022 14.6 0.9 2.1 1 0 0 1 1 1 1 Cripto_Frl-1_Cryptic (CFC) TILa PF12714.7 PIK51691.1 - 0.98 9.4 15.8 0.022 14.7 6.9 2.8 3 0 0 3 3 3 0 TILa domain DnaJ_C PF01556.18 PIK51692.1 - 1.7e-34 119.1 0.1 2.4e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 PIK51692.1 - 5.3e-30 103.3 1.0 8.1e-30 102.7 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3810 PF12725.7 PIK51692.1 - 0.063 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) CBM26 PF16738.5 PIK51692.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Starch-binding module 26 EamA PF00892.20 PIK51693.1 - 4.3e-21 75.5 36.7 1.7e-12 47.7 11.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family GTP_EFTU PF00009.27 PIK51694.1 - 2.3e-33 115.4 0.2 3.9e-31 108.1 0.1 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain IF-2 PF11987.8 PIK51694.1 - 1.7e-28 98.8 2.4 1.3e-27 95.9 0.1 3.2 3 0 0 3 3 3 1 Translation-initiation factor 2 RsgA_GTPase PF03193.16 PIK51694.1 - 3.3e-05 23.9 0.2 0.041 13.8 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 PIK51694.1 - 0.00017 21.6 0.2 0.00092 19.3 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 PIK51694.1 - 0.024 14.1 0.1 0.58 9.6 0.0 2.6 3 0 0 3 3 3 0 ADP-ribosylation factor family TrmB PF01978.19 PIK51694.1 - 0.078 12.9 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB AAA_26 PF13500.6 PIK51694.1 - 0.096 12.5 0.4 0.24 11.2 0.3 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1_Xtn PF16897.5 PIK51694.1 - 0.12 12.3 0.2 0.49 10.4 0.2 2.1 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 PIK51694.1 - 0.15 12.1 1.2 4.2 7.4 0.0 2.9 2 1 0 3 3 3 0 Dynamin family DUF1491 PF07372.12 PIK51694.1 - 7.2 7.0 6.9 6.6 7.2 1.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1491) ubiquitin PF00240.23 PIK51695.1 - 3.8e-28 97.0 0.0 7.2e-28 96.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 PIK51695.1 - 6.7e-28 96.6 1.0 1.7e-27 95.3 1.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 PIK51695.1 - 3.4e-12 46.0 0.4 6.5e-12 45.1 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK51695.1 - 1.3e-05 25.5 0.1 8.2e-05 23.0 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK51695.1 - 0.0006 19.9 0.2 0.0012 18.9 0.2 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 PIK51695.1 - 0.0062 16.4 0.0 0.0095 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK51695.1 - 0.0095 16.3 0.5 0.021 15.2 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 PIK51695.1 - 0.019 15.5 0.2 0.026 15.1 0.2 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Dimer_Tnp_Tn5 PF02281.16 PIK51697.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Transposase Tn5 dimerisation domain FANCM-MHF_bd PF16783.5 PIK51698.1 - 1.2e-23 83.4 0.8 5.2e-23 81.3 0.8 2.3 1 0 0 1 1 1 1 FANCM to MHF binding domain ResIII PF04851.15 PIK51698.1 - 1.9e-20 73.6 2.9 8e-20 71.5 0.0 3.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK51698.1 - 4.4e-19 68.8 0.0 1.9e-18 66.8 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK51698.1 - 2.3e-17 63.3 0.0 6.5e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-CCHC_3 PF13917.6 PIK51699.1 - 0.00024 21.0 0.0 0.00079 19.3 0.0 1.9 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK51699.1 - 0.00091 19.7 0.0 0.002 18.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 PIK51699.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.6 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK51699.1 - 0.0016 18.4 3.3 0.003 17.6 3.3 1.5 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 PIK51699.1 - 0.0077 16.9 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 PIK51699.1 - 0.094 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease Ion_trans PF00520.31 PIK51700.1 - 2e-31 109.1 53.5 7.8e-27 94.1 25.6 3.0 2 1 0 2 2 2 2 Ion transport protein SH3_2 PF07653.17 PIK51700.1 - 7.2e-11 41.6 0.1 1.5e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK51700.1 - 5.4e-10 38.7 0.2 1.1e-09 37.8 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK51700.1 - 1.9e-09 37.2 0.0 4e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_7 PF13499.6 PIK51700.1 - 0.13 12.8 0.0 0.42 11.1 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair PHD PF00628.29 PIK51701.1 - 2.6e-09 36.8 18.7 7.9e-09 35.3 8.1 2.5 1 1 1 2 2 2 2 PHD-finger PHD_2 PF13831.6 PIK51701.1 - 0.003 17.1 0.7 0.003 17.1 0.7 2.3 2 0 0 2 2 2 1 PHD-finger Condensation PF00668.20 PIK51701.1 - 0.022 13.5 2.4 0.037 12.7 2.4 1.2 1 0 0 1 1 1 0 Condensation domain Requiem_N PF14051.6 PIK51701.1 - 0.04 14.1 0.2 0.098 12.9 0.2 1.7 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. CDC45 PF02724.14 PIK51701.1 - 1.2 7.3 17.2 1.7 6.8 17.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF948 PF06103.11 PIK51703.1 - 0.0015 18.7 0.8 1.3 9.3 0.1 2.3 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF948) Yuri_gagarin PF15934.5 PIK51703.1 - 0.013 15.4 1.3 0.013 15.4 1.3 2.1 2 0 0 2 2 2 0 Yuri gagarin LPP PF04728.13 PIK51703.1 - 0.03 14.7 0.4 4.2 7.8 0.1 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper betaPIX_CC PF16523.5 PIK51703.1 - 0.032 14.0 1.2 0.049 13.5 0.2 1.8 2 0 0 2 2 2 0 betaPIX coiled coil Laminin_II PF06009.12 PIK51703.1 - 0.12 12.4 6.0 3.5 7.6 0.9 2.3 2 0 0 2 2 2 0 Laminin Domain II CortBP2 PF09727.9 PIK51703.1 - 0.13 12.1 4.1 0.99 9.3 0.7 2.2 2 0 0 2 2 2 0 Cortactin-binding protein-2 Fmp27_WPPW PF10359.9 PIK51703.1 - 3.2 6.5 12.0 0.67 8.7 2.5 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain APG6_N PF17675.1 PIK51703.1 - 3.5 8.2 7.2 23 5.5 7.2 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 PIK51704.1 - 0.015 15.5 0.8 0.14 12.4 0.8 2.1 1 1 0 1 1 1 0 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 PIK51704.1 - 0.019 15.1 0.8 0.08 13.1 0.1 1.9 2 0 0 2 2 2 0 Tropomyosin like Csm1_N PF18504.1 PIK51704.1 - 0.032 14.6 0.2 0.032 14.6 0.2 1.7 2 0 0 2 2 2 0 Csm1 N-terminal domain RTC PF01137.21 PIK51705.1 - 2.7e-57 193.5 0.0 3.1e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 PIK51705.1 - 6.9e-38 129.3 0.0 1.2e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain NDUFA12 PF05071.16 PIK51706.1 - 1.8e-11 44.7 0.3 3.4e-11 43.8 0.3 1.5 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Cyto_heme_lyase PF01265.17 PIK51707.1 - 2.1e-66 224.5 18.9 1.6e-65 221.6 18.9 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase UDPGT PF00201.18 PIK51708.1 - 6.3e-18 64.8 0.0 8e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 PIK51708.1 - 0.046 13.8 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Nop14 PF04147.12 PIK51708.1 - 0.77 7.9 22.1 1 7.5 22.1 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK51708.1 - 6.9 6.0 23.9 8.5 5.7 23.9 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 PIK51708.1 - 8 4.6 19.5 10 4.2 19.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Tctex-1 PF03645.13 PIK51709.1 - 5.5e-21 74.7 0.1 6.8e-21 74.4 0.1 1.1 1 0 0 1 1 1 1 Tctex-1 family F-box-like PF12937.7 PIK51710.1 - 5.8e-10 38.9 3.6 5.8e-10 38.9 3.6 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 PIK51710.1 - 1.3e-07 31.3 4.6 1.3e-07 31.3 4.6 2.8 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 PIK51710.1 - 0.00068 20.0 13.9 1 9.9 0.4 4.8 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) Spt46 PF17734.1 PIK51710.1 - 0.013 15.3 0.8 0.022 14.6 0.8 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 46 LRR_6 PF13516.6 PIK51710.1 - 0.047 13.8 17.0 18 5.7 0.2 6.7 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 PIK51710.1 - 0.048 14.2 15.6 61 4.8 0.0 7.3 7 0 0 7 7 7 0 Leucine Rich Repeat Ank_2 PF12796.7 PIK51711.1 - 2.5e-21 76.1 0.1 1.1e-11 45.2 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK51711.1 - 1.9e-17 63.4 0.1 1.9e-06 28.3 0.1 3.5 2 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK51711.1 - 7.3e-16 58.0 0.3 3.5e-05 24.0 0.1 4.9 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK51711.1 - 8.3e-12 44.2 1.4 0.25 12.0 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 PIK51711.1 - 4.6e-08 33.1 0.2 0.12 12.9 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat DUF5586 PF17824.1 PIK51711.1 - 0.013 14.6 3.6 0.021 13.9 3.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5586) 7tm_1 PF00001.21 PIK51712.1 - 3.3e-18 66.0 13.1 4.2e-18 65.6 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK51713.1 - 9.2e-10 38.3 0.2 1.4e-09 37.7 0.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK51714.1 - 8.6e-37 126.9 11.2 1.1e-36 126.5 11.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3104 PF11302.8 PIK51714.1 - 0.025 14.3 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) TPR_1 PF00515.28 PIK51715.1 - 3.6e-09 36.0 4.6 0.015 15.1 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK51715.1 - 1.6e-06 27.8 2.4 0.26 11.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK51715.1 - 0.00051 20.2 3.0 0.0011 19.1 2.8 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 PIK51715.1 - 0.0094 16.4 0.0 0.028 14.9 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK51715.1 - 0.01 15.9 0.3 0.086 12.9 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 PIK51715.1 - 0.051 13.9 0.9 12 6.3 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat Aa_trans PF01490.18 PIK51716.1 - 1.6e-32 112.7 41.2 4.3e-31 108.0 41.2 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4134 PF13572.6 PIK51716.1 - 0.017 15.4 1.8 0.067 13.5 0.6 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4134) DUF4267 PF14087.6 PIK51716.1 - 0.033 14.3 0.9 0.083 13.0 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4267) Glyco_transf_21 PF13506.6 PIK51717.1 - 6e-36 123.5 0.0 1.1e-35 122.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 PIK51717.1 - 4e-19 69.4 0.0 5.3e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 PIK51717.1 - 6.4e-05 23.0 3.9 0.00019 21.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 PIK51717.1 - 0.02 14.7 0.0 0.065 13.0 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 2 DUF846 PF05832.12 PIK51718.1 - 0.14 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF846) SNF2_N PF00176.23 PIK51719.1 - 2.2e-55 187.8 0.1 4.8e-55 186.7 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK51719.1 - 8.3e-18 64.8 0.0 2.3e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Rad54_N PF08658.10 PIK51719.1 - 9.8e-11 42.1 1.5 8.7e-10 39.0 1.3 2.2 2 0 0 2 2 2 1 Rad54 N terminal ResIII PF04851.15 PIK51719.1 - 2e-10 40.9 0.0 1.2e-09 38.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 PIK51719.1 - 0.00062 20.1 0.0 0.76 10.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain Rap1a PF18602.1 PIK51719.1 - 0.044 14.1 0.1 0.17 12.2 0.1 2.0 1 0 0 1 1 1 0 Rap1a immunity proteins DUF3641 PF12345.8 PIK51720.1 - 3e-53 179.5 0.1 7.4e-53 178.2 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3641) Radical_SAM PF04055.21 PIK51720.1 - 8.6e-07 29.5 1.1 1.5e-06 28.7 0.3 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 PIK51720.1 - 0.00016 22.0 0.3 0.0004 20.7 0.3 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain CAAP1 PF15335.6 PIK51720.1 - 0.016 15.7 0.1 0.046 14.3 0.1 1.7 1 0 0 1 1 1 0 Caspase activity and apoptosis inhibitor 1 Methyltransf_11 PF08241.12 PIK51721.1 - 1.5e-21 76.8 0.1 3.9e-21 75.5 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK51721.1 - 5.2e-18 65.5 0.0 1.1e-17 64.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK51721.1 - 1.6e-16 60.4 0.0 2.4e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK51721.1 - 2.2e-11 44.4 0.0 4.6e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK51721.1 - 9.3e-08 31.7 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 PIK51721.1 - 1.2e-06 28.0 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 PIK51721.1 - 3e-06 27.2 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK51721.1 - 0.00013 21.6 0.0 0.00025 20.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK51721.1 - 0.00019 20.9 0.1 0.00061 19.3 0.1 1.9 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 PIK51721.1 - 0.00024 21.1 0.0 0.00047 20.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 PIK51721.1 - 0.00049 19.8 0.0 0.0015 18.1 0.0 1.7 2 0 0 2 2 2 1 Nodulation protein S (NodS) PCMT PF01135.19 PIK51721.1 - 0.00089 19.1 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 PIK51721.1 - 0.0016 18.4 0.0 0.0047 16.8 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase PrmA PF06325.13 PIK51721.1 - 0.0017 17.8 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 PIK51721.1 - 0.0036 17.1 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 1 DNA methylase tRNA_U5-meth_tr PF05958.11 PIK51721.1 - 0.006 15.6 0.0 0.0084 15.1 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TehB PF03848.14 PIK51721.1 - 0.0086 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB AdoMet_MTase PF07757.13 PIK51721.1 - 0.012 16.0 0.0 0.023 15.0 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_15 PF09445.10 PIK51721.1 - 0.012 15.2 0.1 0.057 13.0 0.0 1.9 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase MetW PF07021.12 PIK51721.1 - 0.022 14.4 0.3 0.062 12.9 0.1 1.8 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_29 PF03141.16 PIK51721.1 - 0.043 12.4 0.0 0.058 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DREV PF05219.12 PIK51721.1 - 0.073 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase ADH_zinc_N PF00107.26 PIK51721.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TSP_1 PF00090.19 PIK51722.1 - 2.1e-102 335.2 162.4 2.4e-11 43.6 6.4 11.3 11 0 0 11 11 11 11 Thrombospondin type 1 domain CxC6 PF18721.1 PIK51722.1 - 0.14 12.5 0.2 0.14 12.5 0.2 7.9 4 3 4 8 8 8 0 CxC6 like cysteine cluster associated with KDZ transposases Fibrinogen_C PF00147.18 PIK51723.1 - 2.2e-71 240.2 5.3 2.7e-71 239.9 5.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51724.1 - 6.2e-73 245.3 3.6 7.5e-73 245.0 3.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain LRR_9 PF14580.6 PIK51726.1 - 1.9e-73 245.7 1.6 2.6e-73 245.2 1.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK51726.1 - 0.00011 22.5 11.5 0.006 17.0 3.4 3.5 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK51726.1 - 0.00093 18.9 7.4 0.0033 17.2 3.8 2.9 2 1 1 3 3 3 2 Leucine rich repeat HYR PF02494.16 PIK51728.1 - 9.5e-65 214.9 10.6 3.9e-12 46.3 0.0 6.1 6 0 0 6 6 6 6 HYR domain DUF3996 PF13161.6 PIK51728.1 - 0.03 14.0 0.0 32 4.2 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3996) DUF4815 PF16075.5 PIK51728.1 - 0.2 9.9 0.1 20 3.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4815) HYR PF02494.16 PIK51729.1 - 1.5e-34 118.1 1.4 1e-14 54.6 0.0 3.1 3 0 0 3 3 3 3 HYR domain DUF753 PF05444.12 PIK51730.1 - 1.6e-06 28.2 17.9 0.0062 16.5 2.3 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF753) LPD28 PF18843.1 PIK51730.1 - 0.0054 16.3 0.0 11 5.7 0.0 3.2 3 0 0 3 3 3 1 Large polyvalent protein associated domain 28 DUF4112 PF13430.6 PIK51730.1 - 0.088 13.1 0.4 74 3.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) motB PF17613.2 PIK51730.1 - 0.7 9.7 5.3 39 4.0 0.1 3.0 3 0 0 3 3 3 0 Modifier of transcription NADH-G_4Fe-4S_3 PF10588.9 PIK51730.1 - 5 6.8 14.9 14 5.3 0.4 4.0 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF753 PF05444.12 PIK51731.1 - 0.011 15.7 1.3 0.011 15.7 1.3 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF753) LPD28 PF18843.1 PIK51731.1 - 0.085 12.5 0.0 8.2 6.1 0.0 2.8 3 0 0 3 3 3 0 Large polyvalent protein associated domain 28 BESS PF02944.20 PIK51731.1 - 0.14 12.0 0.0 59 3.6 0.0 3.2 3 0 0 3 3 3 0 BESS motif IBV_3B PF03622.13 PIK51731.1 - 0.36 11.0 4.7 85 3.4 0.1 3.9 3 0 0 3 3 3 0 IBV 3B protein motB PF17613.2 PIK51731.1 - 0.5 10.2 2.7 74 3.1 0.1 3.0 3 0 0 3 3 3 0 Modifier of transcription NADH-G_4Fe-4S_3 PF10588.9 PIK51731.1 - 3.4 7.3 14.0 21 4.7 0.4 4.1 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region RGS PF00615.19 PIK51733.1 - 2.7e-31 108.3 7.0 7.7e-10 39.1 1.2 5.7 6 0 0 6 6 6 4 Regulator of G protein signaling domain MPM1 PF17234.2 PIK51733.1 - 6.8 6.9 8.2 9.6 6.4 6.4 2.2 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SGL PF08450.12 PIK51734.1 - 6.2e-69 232.3 0.1 7.2e-69 232.1 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Glu_cyclase_2 PF05096.12 PIK51734.1 - 0.05 13.0 0.0 0.28 10.6 0.0 1.9 2 0 0 2 2 2 0 Glutamine cyclotransferase Reg_prop PF07494.11 PIK51734.1 - 0.076 13.3 0.3 12 6.5 0.0 3.5 3 0 0 3 3 3 0 Two component regulator propeller PQQ_2 PF13360.6 PIK51734.1 - 0.14 11.7 0.0 4.9 6.7 0.0 2.3 2 1 0 2 2 2 0 PQQ-like domain PQQ_3 PF13570.6 PIK51734.1 - 0.16 12.5 0.1 27 5.4 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain TF_AP-2 PF03299.14 PIK51735.1 - 1.3e-82 276.6 0.0 1.6e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 DUF2624 PF11116.8 PIK51735.1 - 0.12 13.3 0.0 0.28 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) Stathmin PF00836.19 PIK51736.1 - 5.6e-22 78.2 14.1 5.6e-22 78.2 14.1 1.7 2 0 0 2 2 2 1 Stathmin family Pannexin_like PF12534.8 PIK51736.1 - 0.16 11.0 2.7 0.19 10.8 2.7 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MDM10 PF12519.8 PIK51736.1 - 0.41 9.4 2.8 0.49 9.2 2.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FHA PF00498.26 PIK51737.1 - 2.1e-08 34.4 0.1 4.7e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK51737.1 - 0.00053 20.2 0.0 0.0018 18.6 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF5604 PF18300.1 PIK51738.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5604) STAS PF01740.21 PIK51739.1 - 8.6e-23 80.2 1.2 5.2e-22 77.7 1.1 2.1 1 1 0 1 1 1 1 STAS domain STAS_2 PF13466.6 PIK51739.1 - 0.011 16.0 0.2 0.065 13.6 0.1 2.1 2 0 0 2 2 2 0 STAS domain FMO-like PF00743.19 PIK51740.1 - 6.6e-52 176.6 0.6 2.2e-39 135.3 0.1 2.1 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK51740.1 - 1.7e-16 60.4 0.0 2.9e-14 53.0 0.0 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK51740.1 - 7.1e-10 38.6 0.0 1.6e-08 34.2 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK51740.1 - 1.7e-07 30.7 0.0 4.1e-06 26.2 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 PIK51740.1 - 0.0052 17.3 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 PIK51740.1 - 0.0086 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_9 PF13454.6 PIK51740.1 - 0.027 14.4 0.1 16 5.4 0.0 3.3 2 1 1 3 3 3 0 FAD-NAD(P)-binding RIH_assoc PF08454.11 PIK51741.1 - 2.4e-32 110.8 2.8 2.4e-32 110.8 2.8 5.1 4 1 1 5 5 5 1 RyR and IP3R Homology associated Ion_trans PF00520.31 PIK51741.1 - 1.8e-16 60.1 6.3 5e-16 58.7 6.3 1.9 1 1 0 1 1 1 1 Ion transport protein RYDR_ITPR PF01365.21 PIK51741.1 - 2.6e-08 33.5 3.8 2.6e-08 33.5 3.8 5.1 4 2 1 5 5 5 1 RIH domain DUF16 PF01519.16 PIK51741.1 - 0.26 11.8 7.3 2.2 8.8 0.7 4.0 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF4551 PF15087.6 PIK51742.1 - 1.4e-95 321.4 13.4 3.3e-92 310.3 12.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4551) Sec20 PF03908.13 PIK51742.1 - 0.0013 18.6 3.3 0.0045 16.9 0.5 3.1 2 1 2 4 4 4 1 Sec20 PI3K_P85_iSH2 PF16454.5 PIK51742.1 - 0.0092 15.6 0.6 0.016 14.8 0.6 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain p450 PF00067.22 PIK51743.1 - 8e-78 262.2 0.0 1e-77 261.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUSP PF06337.12 PIK51743.1 - 0.076 13.6 0.0 0.16 12.6 0.0 1.6 1 0 0 1 1 1 0 DUSP domain p450 PF00067.22 PIK51744.1 - 2.3e-115 386.0 0.0 2.6e-115 385.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MMR_HSR1 PF01926.23 PIK51745.1 - 2.3e-14 53.4 0.2 5.1e-12 45.9 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GN3L_Grn1 PF08701.11 PIK51745.1 - 4.6e-14 52.3 15.0 4.6e-14 52.3 15.0 4.2 3 2 1 4 4 4 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.18 PIK51745.1 - 3.5e-08 33.1 0.3 1.3e-06 28.0 0.1 2.3 1 1 1 2 2 2 1 Ferrous iron transport protein B DUF829 PF05705.14 PIK51745.1 - 0.16 11.9 0.0 0.95 9.3 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF829) DUF4434 PF14488.6 PIK51745.1 - 0.38 10.7 1.4 1.9 8.5 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4434) DNA_pol_phi PF04931.13 PIK51745.1 - 1.6 6.7 24.6 2.9 5.9 24.6 1.5 1 0 0 1 1 1 0 DNA polymerase phi Merozoite_SPAM PF07133.11 PIK51745.1 - 5.9 6.8 39.8 0.58 10.1 29.3 2.3 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) RCC1 PF00415.18 PIK51746.1 - 5.1e-57 190.3 22.4 2.5e-11 44.0 0.5 8.8 8 1 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK51746.1 - 3.9e-36 122.1 30.5 6.5e-11 41.7 0.3 7.7 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Clathrin PF00637.20 PIK51746.1 - 0.0097 15.8 0.3 3.7 7.4 0.0 2.6 2 0 0 2 2 2 2 Region in Clathrin and VPS 7tm_1 PF00001.21 PIK51747.1 - 1.3e-23 83.6 15.6 1.8e-23 83.2 15.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK51747.1 - 1.5e-07 31.3 20.6 2.5e-07 30.6 20.6 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK51747.1 - 0.00013 21.4 14.5 0.00021 20.7 14.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK51748.1 - 1.2e-34 119.9 24.0 1.4e-34 119.6 24.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK51748.1 - 4.7e-07 29.4 21.0 7.4e-07 28.8 21.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK51748.1 - 5.4e-07 29.5 23.8 1.1e-06 28.5 23.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx RT_RNaseH_2 PF17919.1 PIK51749.1 - 0.013 15.6 0.1 0.026 14.6 0.1 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase MIT_C PF16565.5 PIK51749.1 - 0.078 13.0 0.0 1.5 8.8 0.0 2.1 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT MULE PF10551.9 PIK51750.1 - 9.7e-05 22.7 0.0 0.00051 20.4 0.0 2.2 2 0 0 2 2 2 1 MULE transposase domain SWIM PF04434.17 PIK51750.1 - 0.006 16.2 0.1 0.016 14.9 0.1 1.7 1 0 0 1 1 1 1 SWIM zinc finger Laminin_EGF PF00053.24 PIK51750.1 - 2.9 8.1 6.1 17 5.7 1.0 2.9 2 1 0 2 2 2 0 Laminin EGF domain DUF1664 PF07889.12 PIK51753.1 - 0.02 14.9 25.6 0.029 14.4 6.5 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) GAS PF13851.6 PIK51753.1 - 0.044 13.1 58.7 0.012 14.9 28.3 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK51753.1 - 0.07 12.9 62.0 0.68 9.7 20.9 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family KASH_CCD PF14662.6 PIK51753.1 - 0.81 9.5 58.0 0.15 11.9 8.2 2.8 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 PIK51753.1 - 1.9 7.3 55.7 5.5 5.8 25.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.6 PIK51753.1 - 5.4 6.6 56.8 3 7.5 29.6 3.6 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease GD_N PF16030.5 PIK51753.1 - 6 7.2 7.5 10 6.5 0.6 3.0 1 1 2 3 3 3 0 Serine protease gd N-terminus Zw10 PF06248.13 PIK51754.1 - 1.2e-100 337.6 23.6 1.2e-66 225.5 14.1 3.1 2 1 1 3 3 3 2 Centromere/kinetochore Zw10 Sec8_exocyst PF04048.14 PIK51754.1 - 0.0016 18.4 0.2 0.011 15.6 0.1 2.5 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain BLOC1_2 PF10046.9 PIK51754.1 - 0.0073 16.6 1.1 0.077 13.3 0.3 3.2 3 0 0 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TolA_bind_tri PF16331.5 PIK51754.1 - 0.18 11.9 1.7 31 4.7 0.2 3.8 3 0 0 3 3 3 0 TolA binding protein trimerisation Vps51 PF08700.11 PIK51754.1 - 0.2 11.8 3.8 0.39 10.8 0.1 3.5 4 0 0 4 4 4 0 Vps51/Vps67 HsbA PF12296.8 PIK51754.1 - 0.51 10.8 4.7 23 5.4 0.2 3.9 3 1 0 3 3 3 0 Hydrophobic surface binding protein A Ribosomal_L50 PF10501.9 PIK51755.1 - 1.4e-11 44.5 0.7 2.5e-11 43.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal subunit 39S BLI1 PF17324.2 PIK51755.1 - 0.56 10.9 3.8 0.19 12.4 0.4 1.9 2 1 1 3 3 3 0 BLOC-1 interactor 1 COX6A PF02046.15 PIK51756.1 - 5.2e-07 30.1 0.3 6.5e-07 29.8 0.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa RyR PF02026.16 PIK51756.1 - 0.0013 18.9 0.0 0.0019 18.4 0.0 1.2 1 0 0 1 1 1 1 RyR domain LtrA PF06772.11 PIK51756.1 - 0.052 12.8 0.0 0.067 12.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) Pkinase PF00069.25 PIK51757.1 - 2.4e-45 154.9 0.0 3.2e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51757.1 - 1.5e-28 99.8 0.0 2e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK51757.1 - 6.4e-08 32.3 0.0 1.1e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK51757.1 - 0.00036 19.4 0.2 0.00051 18.9 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK51757.1 - 0.0018 17.3 0.1 0.0029 16.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK51757.1 - 0.085 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 PIK51758.1 - 0.0018 17.7 0.3 0.0024 17.3 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain SKICH PF17751.1 PIK51759.1 - 6.1e-24 84.5 0.9 1.3e-23 83.5 0.9 1.5 1 0 0 1 1 1 1 SKICH domain Exo_endo_phos PF03372.23 PIK51759.1 - 8.8e-09 35.2 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family 7tm_3 PF00003.22 PIK51760.1 - 2.1e-26 93.1 28.4 3.9e-26 92.2 28.4 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 PIK51760.1 - 5.6e-15 55.3 0.0 8.2e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region TspO_MBR PF03073.15 PIK51760.1 - 1.6 8.8 19.3 0.11 12.6 5.3 2.8 2 1 1 3 3 3 0 TspO/MBR family Sep15_SelM PF08806.11 PIK51761.1 - 2.3e-10 40.5 0.0 2.9e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain Prp19 PF08606.11 PIK51762.1 - 4.3e-32 109.9 2.1 4.3e-32 109.9 2.1 2.0 2 0 0 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 PIK51762.1 - 3.7e-19 68.7 7.5 0.00021 22.0 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat U-box PF04564.15 PIK51762.1 - 3.2e-07 30.4 0.0 9.4e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 U-box domain ANAPC4_WD40 PF12894.7 PIK51762.1 - 1.4e-06 28.5 0.0 0.31 11.3 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain zf-Nse PF11789.8 PIK51762.1 - 9.2e-05 22.2 0.2 0.00029 20.6 0.1 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Ge1_WD40 PF16529.5 PIK51762.1 - 0.029 13.4 0.4 4 6.3 0.0 2.2 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK51762.1 - 0.04 12.6 0.2 0.056 12.1 0.2 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PAS_11 PF14598.6 PIK51762.1 - 0.12 12.5 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 PAS domain Pro_isomerase PF00160.21 PIK51763.1 - 5.4e-51 173.0 0.0 6.4e-51 172.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_S9 PF00326.21 PIK51764.1 - 8.2e-08 32.0 0.0 1e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 PIK51764.1 - 0.0026 17.1 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 PIK51764.1 - 0.0039 16.9 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 PIK51764.1 - 0.061 12.9 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 PIK51764.1 - 0.095 12.3 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK51765.1 - 8.7e-28 97.2 0.0 1.4e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 PIK51765.1 - 1.7e-09 37.7 0.9 1.3e-05 25.0 0.7 2.5 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK51765.1 - 2.5e-08 33.5 0.1 0.0009 18.6 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 COesterase PF00135.28 PIK51765.1 - 7.7e-05 21.7 0.2 0.00015 20.8 0.2 1.4 1 0 0 1 1 1 1 Carboxylesterase family DLH PF01738.18 PIK51765.1 - 0.0018 17.8 0.2 0.072 12.6 0.0 2.4 3 0 0 3 3 3 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 PIK51765.1 - 0.0051 17.5 0.1 0.0086 16.7 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 PIK51765.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 Putative esterase PARP PF00644.20 PIK51766.1 - 8.6e-50 169.1 0.0 8.6e-50 169.1 0.0 2.5 4 0 0 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 PIK51766.1 - 1.1e-39 135.7 0.7 3.1e-39 134.2 0.7 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 PIK51766.1 - 1.6e-27 95.4 2.3 4.3e-27 94.0 2.3 1.8 1 0 0 1 1 1 1 WGR domain Nucleotid_trans PF03407.16 PIK51767.1 - 3.5e-28 99.0 0.0 5e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase RVT_1 PF00078.27 PIK51768.1 - 1.8e-31 109.4 0.0 2.3e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK51769.1 - 2.7e-23 82.4 0.0 5.8e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK51769.1 - 8.3e-18 64.3 1.0 8.3e-18 64.3 1.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK51769.1 - 0.0027 17.9 0.6 0.0027 17.9 0.6 2.7 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 PIK51769.1 - 0.012 15.4 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain MycE_N PF17843.1 PIK51769.1 - 0.049 14.1 0.0 0.093 13.2 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal DUF2284 PF10050.9 PIK51769.1 - 0.092 12.5 0.5 13 5.5 0.2 2.3 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) RT_RNaseH PF17917.1 PIK51770.1 - 0.016 15.5 0.0 0.047 14.0 0.0 1.7 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase UIM PF02809.20 PIK51770.1 - 0.15 12.1 1.7 0.32 11.0 1.7 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4371 PF14291.6 PIK51771.1 - 1.4e-37 129.6 1.1 1.4e-37 129.6 1.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK51771.1 - 0.021 14.7 0.4 0.15 11.9 0.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF 659) dDENN PF03455.19 PIK51773.1 - 1.8e-16 59.9 2.4 2.4e-16 59.4 1.5 1.8 2 0 0 2 2 2 1 dDENN domain RUN PF02759.19 PIK51774.1 - 8.6e-11 41.9 0.1 1.5e-10 41.2 0.1 1.4 1 0 0 1 1 1 1 RUN domain PLAT PF01477.23 PIK51774.1 - 5.3e-06 27.0 0.0 1.1e-05 26.0 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain CDC37_C PF08564.10 PIK51775.1 - 2.1e-13 50.3 0.9 2.1e-13 50.3 0.9 2.1 1 1 1 2 2 2 1 Cdc37 C terminal domain CDC37_M PF08565.11 PIK51775.1 - 0.041 13.8 0.2 0.087 12.7 0.2 1.5 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain PEHE PF15275.6 PIK51775.1 - 0.086 13.5 0.0 0.086 13.5 0.0 1.8 2 0 0 2 2 2 0 PEHE domain Ribosomal_60s PF00428.19 PIK51775.1 - 7.6 7.2 10.6 11 6.7 2.0 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein CUE PF02845.16 PIK51776.1 - 8.2e-15 54.2 0.1 1.4e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 CUE domain C2 PF00168.30 PIK51776.1 - 3.9e-13 49.6 0.0 5.8e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 C2 domain HS1_rep PF02218.15 PIK51777.1 - 4.3e-113 369.3 85.8 8.2e-20 70.8 7.2 7.6 7 0 0 7 7 7 7 Repeat in HS1/Cortactin SH3_9 PF14604.6 PIK51777.1 - 5.7e-17 61.3 0.3 1.4e-16 60.1 0.3 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK51777.1 - 1.2e-16 60.0 0.2 2.7e-16 58.9 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK51777.1 - 2e-07 30.6 0.0 4e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.6 PIK51777.1 - 2e-05 25.0 9.4 17 5.9 0.1 6.8 1 1 5 7 7 7 1 TMEM210 family DUF3987 PF13148.6 PIK51777.1 - 7.9 5.4 10.9 15 4.5 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) LSM PF01423.22 PIK51778.1 - 2.4e-16 59.2 0.2 3.1e-16 58.8 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 PIK51778.1 - 0.0051 16.4 0.0 0.0086 15.7 0.0 1.4 1 0 0 1 1 1 1 Hfq protein Spc24 PF08286.11 PIK51779.1 - 2.7e-10 40.4 0.9 1.8e-09 37.8 0.9 2.2 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 PhageMin_Tail PF10145.9 PIK51779.1 - 0.0077 16.1 2.2 0.01 15.7 2.2 1.2 1 0 0 1 1 1 1 Phage-related minor tail protein Radical_SAM_N PF08497.10 PIK51779.1 - 0.0098 15.2 0.9 0.013 14.8 0.9 1.1 1 0 0 1 1 1 1 Radical SAM N-terminal FAM27 PF15832.5 PIK51779.1 - 0.012 16.1 3.3 0.012 16.1 3.3 1.9 2 0 0 2 2 2 0 FAM27 D and E protein family WHEP-TRS PF00458.20 PIK51779.1 - 0.04 14.1 2.0 0.069 13.3 2.0 1.4 1 0 0 1 1 1 0 WHEP-TRS domain TBK1_CCD1 PF18394.1 PIK51779.1 - 0.043 13.4 2.0 0.058 13.0 2.0 1.2 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 DUF737 PF05300.11 PIK51779.1 - 0.054 13.8 5.2 0.07 13.5 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Bac_luciferase PF00296.20 PIK51779.1 - 0.15 11.5 0.2 0.18 11.2 0.2 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase Het-C PF07217.11 PIK51779.1 - 0.26 9.7 2.0 0.28 9.6 2.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C PRK PF00485.18 PIK51780.1 - 5e-22 78.6 0.5 6.5e-22 78.2 0.5 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Oxygenase-NA PF09859.9 PIK51780.1 - 0.047 13.2 0.0 0.054 13.0 0.0 1.1 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA DUF572 PF04502.13 PIK51781.1 - 1.2e-81 274.9 18.7 2.4e-81 274.0 18.7 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF572) RGS_DHEX PF18148.1 PIK51781.1 - 0.45 10.7 5.1 1.9 8.7 1.4 2.9 1 1 0 2 2 2 0 Regulator of G-protein signalling DHEX domain SPT16 PF08644.11 PIK51781.1 - 5.9 7.1 10.2 0.65 10.2 5.4 1.9 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Bcl-2 PF00452.19 PIK51782.1 - 2.1e-15 57.2 0.0 5.5e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family DUF771 PF05595.11 PIK51782.1 - 0.091 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF771) DUF4807 PF16065.5 PIK51782.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4807) Carn_acyltransf PF00755.20 PIK51783.1 - 5.2e-127 424.9 0.0 5.7e-121 405.0 0.0 2.2 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase Carn_acyltransf PF00755.20 PIK51784.1 - 5e-54 183.9 0.2 1.2e-47 162.9 0.0 2.8 1 1 2 3 3 3 2 Choline/Carnitine o-acyltransferase CPT_N PF16484.5 PIK51784.1 - 3.2e-19 68.6 0.0 6.1e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus RVT_1 PF00078.27 PIK51784.1 - 6.7e-17 61.7 0.1 1.2e-16 61.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YidD PF01809.18 PIK51784.1 - 0.022 14.7 0.3 0.051 13.5 0.3 1.6 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor RHH_7 PF16777.5 PIK51784.1 - 0.19 12.2 0.4 0.69 10.3 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG Aa_trans PF01490.18 PIK51785.1 - 3.2e-66 223.8 21.7 3.9e-66 223.5 21.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 PIK51785.1 - 0.0082 15.0 0.4 0.0082 15.0 0.4 3.4 2 1 1 3 3 3 2 Spore germination protein DUF4010 PF13194.6 PIK51785.1 - 0.068 12.9 9.7 2.9 7.5 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4010) Cytochrom_B561 PF03188.16 PIK51785.1 - 0.3 11.2 12.4 2.7 8.1 0.4 4.2 4 0 0 4 4 4 0 Eukaryotic cytochrome b561 DUF4131 PF13567.6 PIK51785.1 - 0.4 10.3 0.1 0.4 10.3 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Proteasome PF00227.26 PIK51786.1 - 1.9e-54 184.0 0.0 2.3e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 PIK51786.1 - 1e-12 47.5 0.0 1.7e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature 2TM PF13239.6 PIK51787.1 - 0.0054 17.0 0.1 0.0075 16.5 0.1 1.2 1 0 0 1 1 1 1 2TM domain DHHC PF01529.20 PIK51787.1 - 0.027 14.6 0.2 0.034 14.3 0.2 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase Mut7-C PF01927.16 PIK51788.1 - 1.7e-23 83.4 3.2 3.5e-16 59.6 1.3 2.6 2 0 0 2 2 2 2 Mut7-C RNAse domain DNA_pol_A_exo1 PF01612.20 PIK51788.1 - 1.4e-18 67.2 0.1 3.5e-18 65.9 0.1 1.7 1 0 0 1 1 1 1 3'-5' exonuclease A2L_zn_ribbon PF08792.10 PIK51788.1 - 0.31 10.8 3.3 2.8 7.7 0.4 2.6 2 0 0 2 2 2 0 A2L zinc ribbon domain YBD PF17725.1 PIK51789.1 - 8.7e-96 319.7 2.0 1e-95 319.5 2.0 1.0 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 PIK51790.1 - 2.7e-28 97.9 0.0 5.2e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 TEA/ATTS domain MSP1a PF11670.8 PIK51790.1 - 0.51 9.6 4.8 0.21 10.9 0.9 1.9 2 0 0 2 2 2 0 Major surface protein 1a (MSP1a) CH PF00307.31 PIK51791.1 - 6.3e-29 100.3 7.0 3.8e-15 56.0 0.2 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain IF-2B PF01008.17 PIK51791.1 - 0.036 13.3 0.3 0.053 12.7 0.3 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family PriA_C PF18074.1 PIK51791.1 - 0.042 14.7 0.8 0.12 13.2 0.8 1.8 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain Ada3 PF10198.9 PIK51791.1 - 0.6 10.3 6.3 0.3 11.2 3.3 2.1 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 ANAPC4_WD40 PF12894.7 PIK51792.1 - 5.2e-07 29.9 3.4 3.5e-06 27.2 0.7 3.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK51792.1 - 0.00032 21.4 6.6 0.04 14.8 0.4 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat NiFe_hyd_SSU_C PF14720.6 PIK51792.1 - 0.11 12.8 0.3 0.25 11.7 0.3 1.5 1 0 0 1 1 1 0 NiFe/NiFeSe hydrogenase small subunit C-terminal RFX_DNA_binding PF02257.15 PIK51794.1 - 2.4e-16 60.1 0.1 4.3e-16 59.3 0.1 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain ARID PF01388.21 PIK51794.1 - 3e-14 53.4 0.0 7.4e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain RVT_1 PF00078.27 PIK51795.1 - 5e-24 85.1 0.5 3.5e-23 82.3 0.2 2.3 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK51795.1 - 0.0055 16.6 0.2 0.016 15.1 0.0 1.7 2 0 0 2 2 2 1 Med18 protein CLCA PF08434.11 PIK51796.1 - 8.9e-46 156.4 0.1 8.8e-39 133.4 0.0 2.2 1 1 1 2 2 2 2 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK51796.1 - 8.4e-16 58.7 0.0 4.8e-15 56.3 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK51796.1 - 7e-13 49.2 0.0 1.5e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK51796.1 - 1e-07 31.6 0.0 1.7e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK51796.1 - 2.4e-05 24.3 0.0 4.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF444 PF04285.12 PIK51796.1 - 0.032 13.3 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF444) TMEM154 PF15102.6 PIK51796.1 - 0.13 12.1 0.0 0.42 10.5 0.0 1.7 2 0 0 2 2 2 0 TMEM154 protein family CobT_C PF11775.8 PIK51796.1 - 0.15 11.7 0.0 0.35 10.5 0.0 1.5 1 1 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain TMEM52 PF14979.6 PIK51796.1 - 0.15 12.0 0.3 0.32 10.9 0.3 1.5 1 0 0 1 1 1 0 Transmembrane 52 Shisa PF13908.6 PIK51796.1 - 0.21 11.8 0.0 0.21 11.8 0.0 1.6 2 0 0 2 2 1 0 Wnt and FGF inhibitory regulator Corona_S2 PF01601.16 PIK51796.1 - 0.49 8.8 2.8 0.35 9.3 1.3 1.4 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein Sulfotransfer_1 PF00685.27 PIK51797.1 - 4.3e-40 137.9 0.0 5.5e-40 137.5 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Fringe PF02434.16 PIK51799.1 - 4.3e-59 200.0 0.0 5.1e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Laminin_EGF PF00053.24 PIK51800.1 - 2.1 8.6 41.4 0.29 11.3 7.3 4.4 3 2 1 4 4 4 0 Laminin EGF domain Peptidase_C21 PF05381.12 PIK51802.1 - 0.022 15.1 0.4 0.14 12.5 0.0 2.3 2 0 0 2 2 2 0 Tymovirus endopeptidase RNA_pol_Rpc4 PF05132.14 PIK51802.1 - 5 7.5 10.6 0.049 14.1 1.2 2.4 3 0 0 3 3 3 0 RNA polymerase III RPC4 Nop25 PF09805.9 PIK51803.1 - 0.25 11.8 5.3 1.2 9.7 5.3 2.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) RVT_1 PF00078.27 PIK51804.1 - 0.00011 21.8 0.1 0.00016 21.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Bcl-2 PF00452.19 PIK51805.1 - 2.2e-11 44.3 0.0 2.8e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family DUF1298 PF06974.13 PIK51806.1 - 0.0071 16.3 0.0 0.0085 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) RVT_2 PF07727.14 PIK51807.1 - 9.9e-33 113.8 0.0 1.2e-32 113.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK51808.1 - 6.1e-15 55.3 0.0 9.1e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cas_Cas1 PF01867.16 PIK51808.1 - 0.032 13.4 0.1 0.048 12.8 0.1 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas1 NOGCT PF08155.11 PIK51808.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 NOGCT (NUC087) domain GIY-YIG PF01541.24 PIK51809.1 - 1.9e-05 24.9 0.7 4.7e-05 23.6 0.7 1.7 1 0 0 1 1 1 1 GIY-YIG catalytic domain Lectin_C PF00059.21 PIK51810.1 - 2.6e-17 63.5 1.5 8.7e-17 61.8 1.5 1.7 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK51810.1 - 0.0087 15.7 0.5 0.012 15.3 0.5 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK51811.1 - 0.00043 21.0 0.5 0.0021 18.7 0.5 1.9 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK51811.1 - 0.005 16.5 0.4 0.0055 16.4 0.4 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like RVT_1 PF00078.27 PIK51812.1 - 7.2e-21 74.7 0.0 2.3e-20 73.1 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2040 PF09745.9 PIK51814.1 - 2.3e-36 124.5 26.2 2.3e-36 124.5 26.2 3.7 2 2 1 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) ATP_bind_1 PF03029.17 PIK51815.1 - 3.3e-87 292.3 0.0 3.8e-87 292.1 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 PIK51815.1 - 0.0004 20.9 0.0 0.00096 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK51815.1 - 0.0036 17.7 0.0 0.0072 16.7 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_17 PF13207.6 PIK51815.1 - 0.0051 17.2 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK51815.1 - 0.0088 16.3 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK51815.1 - 0.015 15.4 0.1 0.044 13.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_31 PF13614.6 PIK51815.1 - 0.018 15.0 0.0 0.41 10.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK51815.1 - 0.021 15.0 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK51815.1 - 0.021 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 PIK51815.1 - 0.034 14.1 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 PIK51815.1 - 0.039 13.9 0.1 1.3 8.9 0.0 2.5 3 0 0 3 3 3 0 RsgA GTPase CLP1_P PF16575.5 PIK51815.1 - 0.06 13.1 0.0 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 PIK51815.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 PIK51815.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Adenylate kinase AAA PF00004.29 PIK51815.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 PIK51815.1 - 0.14 12.0 0.0 0.9 9.4 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK51815.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 PIK51815.1 - 0.16 12.4 0.0 0.48 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 PIK51815.1 - 0.18 11.7 0.3 4.3 7.2 0.0 2.7 3 1 1 4 4 4 0 NTPase ABC_tran PF00005.27 PIK51815.1 - 0.22 12.0 0.0 0.38 11.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 PIK51815.1 - 0.28 10.9 0.0 0.46 10.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Ribosomal_60s PF00428.19 PIK51816.1 - 2.1e-09 37.8 0.0 3.5e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein TRAM_LAG1_CLN8 PF03798.16 PIK51817.1 - 4.6e-26 91.8 9.4 6.9e-26 91.2 9.4 1.2 1 0 0 1 1 1 1 TLC domain DUF1325 PF07039.11 PIK51818.1 - 7e-36 123.2 0.0 8.3e-36 123.0 0.0 1.0 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 PIK51818.1 - 0.0061 16.3 0.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain Top6b_C PF18000.1 PIK51818.1 - 0.087 13.0 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain TUDOR PF00567.24 PIK51818.1 - 0.15 12.1 0.0 2.4 8.2 0.0 2.1 1 1 1 2 2 2 0 Tudor domain ubiquitin PF00240.23 PIK51819.1 - 2.1e-09 37.0 0.5 2.9e-09 36.6 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 PIK51819.1 - 0.0013 18.6 0.6 0.0015 18.3 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 PIK51819.1 - 0.015 15.4 0.0 0.026 14.6 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ABC_membrane PF00664.23 PIK51820.1 - 4e-45 154.6 17.4 9.8e-26 91.0 8.0 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 PIK51820.1 - 2.6e-12 47.4 0.0 6.5e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 PIK51820.1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ClpB_D2-small PF10431.9 PIK51821.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 1 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein DUF1445 PF07286.12 PIK51822.1 - 4.1e-16 59.2 0.0 7.8e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) DUF4392 PF14336.6 PIK51822.1 - 2.3e-14 53.5 0.0 3.1e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.12 PIK51823.1 - 0.004 17.1 0.0 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1445) DUF5044 PF16447.5 PIK51823.1 - 0.0064 16.3 0.0 0.01 15.7 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5044) EGF PF00008.27 PIK51824.1 - 1.9e-38 130.3 152.9 1.5e-06 28.4 7.8 12.3 11 0 0 11 11 11 10 EGF-like domain hEGF PF12661.7 PIK51824.1 - 2.9e-11 43.6 148.9 0.001 19.6 9.0 13.9 14 1 0 14 14 14 9 Human growth factor-like EGF EGF_2 PF07974.13 PIK51824.1 - 1.3e-05 25.5 179.6 0.018 15.4 10.4 12.0 11 1 1 12 12 12 8 EGF-like domain HYR PF02494.16 PIK51824.1 - 0.00091 19.5 6.3 0.002 18.4 0.6 3.7 3 1 0 3 3 3 1 HYR domain Big_9 PF17963.1 PIK51824.1 - 0.001 19.8 1.6 4.4 8.1 0.1 4.2 4 0 0 4 4 4 2 Bacterial Ig domain Cadherin_4 PF17803.1 PIK51824.1 - 0.012 16.2 0.1 0.95 10.1 0.0 2.8 2 0 0 2 2 2 0 Bacterial cadherin-like domain FlgM PF04316.13 PIK51825.1 - 0.91 9.9 6.3 0.18 12.2 1.4 2.3 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Spc7 PF08317.11 PIK51825.1 - 2.1 7.2 36.4 1.4 7.8 25.4 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 PIK51825.1 - 2.6 7.3 23.3 6.4 6.0 5.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) RIIa PF02197.17 PIK51826.1 - 0.052 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit GST_C_6 PF17171.4 PIK51826.1 - 0.088 12.6 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SKA1 PF07160.12 PIK51827.1 - 1.1e-51 176.0 5.3 1.4e-51 175.7 5.3 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Erf4 PF10256.9 PIK51827.1 - 0.015 15.4 0.5 0.2 11.7 0.1 2.5 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Glyco_hydro_115 PF15979.5 PIK51827.1 - 0.035 13.5 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 115 Hypoth_Ymh PF09509.10 PIK51827.1 - 0.062 13.2 0.7 0.13 12.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) DUF1043 PF06295.12 PIK51827.1 - 0.26 11.3 7.4 3.1 7.8 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) DivIC PF04977.15 PIK51827.1 - 0.55 10.0 3.3 0.66 9.8 0.2 2.4 2 0 0 2 2 2 0 Septum formation initiator DUF745 PF05335.13 PIK51827.1 - 1.7 8.3 6.8 2.6 7.7 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Laminin_EGF PF00053.24 PIK51829.1 - 3.8e-60 199.8 154.7 6.6e-11 42.2 10.6 9.6 8 1 1 9 9 9 8 Laminin EGF domain Laminin_B PF00052.18 PIK51829.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Laminin B (Domain IV) Laminin_EGF PF00053.24 PIK51830.1 - 8e-39 131.6 95.3 6.1e-10 39.1 9.3 6.3 5 1 1 6 6 6 5 Laminin EGF domain Laminin_G_2 PF02210.24 PIK51830.1 - 3.7e-20 72.8 0.4 2e-10 41.3 0.0 4.1 3 1 1 4 4 4 3 Laminin G domain Laminin_G_1 PF00054.23 PIK51830.1 - 3.4e-16 59.7 0.0 6.8e-09 36.0 0.0 3.5 2 1 0 3 3 3 2 Laminin G domain Laminin_II PF06009.12 PIK51830.1 - 6.7e-05 22.9 6.1 6.7e-05 22.9 6.1 5.0 4 1 1 5 5 5 3 Laminin Domain II Laminin_G_3 PF13385.6 PIK51830.1 - 0.0043 17.2 1.2 0.0088 16.2 0.1 2.1 3 0 0 3 3 1 1 Concanavalin A-like lectin/glucanases superfamily CREPT PF16566.5 PIK51830.1 - 0.03 14.5 8.4 0.097 12.8 2.5 3.4 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4988 PF16378.5 PIK51830.1 - 0.063 12.9 10.2 0.23 11.1 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function Seryl_tRNA_N PF02403.22 PIK51830.1 - 0.43 10.8 15.9 0.34 11.2 0.5 3.6 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.8 PIK51830.1 - 0.57 10.2 10.5 0.58 10.2 0.2 3.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding PspA_IM30 PF04012.12 PIK51830.1 - 0.83 9.2 16.8 0.53 9.8 1.0 3.5 3 1 0 3 3 3 0 PspA/IM30 family Fez1 PF06818.15 PIK51830.1 - 0.85 10.0 20.4 0.13 12.7 2.3 3.5 2 1 1 4 4 4 0 Fez1 CtIP_N PF10482.9 PIK51830.1 - 1 9.5 8.8 1.6 8.8 1.2 3.8 3 0 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain TPR_MLP1_2 PF07926.12 PIK51830.1 - 1.1 9.4 28.4 0.018 15.1 5.1 4.3 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein XhlA PF10779.9 PIK51830.1 - 3.3 8.0 8.1 4.4 7.6 0.1 3.6 3 1 0 3 3 3 0 Haemolysin XhlA HMMR_N PF15905.5 PIK51830.1 - 4.6 6.6 16.7 0.14 11.6 2.5 3.1 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 PIK51830.1 - 7 6.7 22.7 5 7.1 0.3 4.5 3 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 kleA_kleC PF17383.2 PIK51830.1 - 7.6 6.9 6.6 1.3 9.4 0.2 3.0 4 0 0 4 4 3 0 Uncharacterized KorC regulated protein A Laminin_G_1 PF00054.23 PIK51831.1 - 1.1e-20 74.1 0.2 2.8e-14 53.5 0.0 2.1 1 1 1 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 PIK51831.1 - 1.8e-18 67.3 0.1 6e-16 59.2 0.0 2.1 1 1 1 2 2 2 2 Laminin G domain ASC PF00858.24 PIK51832.1 - 1.2e-101 340.9 2.4 1.5e-101 340.5 2.4 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel GA PF01468.17 PIK51832.1 - 0.098 13.0 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 GA module BSMAP PF12280.8 PIK51832.1 - 3 8.0 7.1 0.1 12.8 0.8 1.6 2 0 0 2 2 2 0 Brain specific membrane anchored protein W2 PF02020.18 PIK51833.1 - 2.6e-22 78.8 1.1 7.6e-22 77.2 1.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 PIK51833.1 - 2e-10 39.9 9.3 0.00051 19.7 0.1 4.6 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 PIK51833.1 - 3e-08 33.6 0.0 7.1e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 PIK51833.1 - 0.0014 16.9 7.9 0.024 12.8 0.2 3.0 2 1 1 3 3 3 3 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 PIK51833.1 - 0.074 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Hexapep_2 PF14602.6 PIK51833.1 - 0.75 9.6 15.6 3.4 7.5 4.6 4.7 2 2 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase UDPG_MGDP_dh PF00984.19 PIK51834.1 - 4.4e-32 110.1 0.0 1.1e-31 108.8 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 PIK51834.1 - 3.8e-27 95.1 0.1 5.8e-27 94.5 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 PIK51834.1 - 7.9e-26 90.5 0.0 2.1e-25 89.1 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Staphostatin_A PF09022.10 PIK51834.1 - 0.051 13.5 0.1 0.14 12.1 0.1 1.7 1 1 0 1 1 1 0 Staphostatin A UDPG_MGDP_dh_N PF03721.14 PIK51835.1 - 1.1e-28 100.0 0.0 1.3e-28 99.8 0.0 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 PIK51835.1 - 0.0083 16.2 0.0 3.8 7.6 0.0 2.0 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 PIK51835.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 PIK51835.1 - 0.034 14.1 0.0 0.087 12.8 0.0 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sacchrp_dh_NADP PF03435.18 PIK51835.1 - 0.073 13.3 0.0 0.074 13.3 0.0 1.3 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Zona_pellucida PF00100.23 PIK51836.1 - 4.2e-35 121.8 2.5 4.2e-35 121.8 2.5 1.9 2 0 0 2 2 2 1 Zona pellucida-like domain Ammonium_transp PF00909.21 PIK51837.1 - 2.3e-92 309.7 19.4 2.7e-92 309.5 19.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Homeodomain PF00046.29 PIK51838.1 - 2.9e-24 84.7 5.3 7.7e-23 80.1 4.7 2.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 PIK51838.1 - 2.1e-05 24.4 0.2 0.0004 20.2 0.2 2.7 2 0 0 2 2 2 1 Homeobox KN domain Cadherin_3 PF16184.5 PIK51838.1 - 0.0035 17.3 0.2 0.0065 16.5 0.2 1.4 1 0 0 1 1 1 1 Cadherin-like DUF1323 PF07037.11 PIK51838.1 - 0.09 13.2 0.1 0.26 11.7 0.0 1.7 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) Alpha_adaptin_C PF02296.16 PIK51839.1 - 3e-35 120.8 0.0 4.2e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain PEPcase PF00311.17 PIK51839.1 - 0.13 10.3 0.0 0.18 9.8 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Adaptin_N PF01602.20 PIK51840.1 - 8.7e-125 417.2 5.8 3.4e-124 415.3 2.1 2.0 1 1 1 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 PIK51840.1 - 4.2e-08 33.5 0.0 8.4e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 PIK51840.1 - 0.00013 22.1 2.1 0.019 15.0 0.0 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK51840.1 - 0.0005 20.4 3.1 0.21 12.0 0.1 4.2 4 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 PIK51840.1 - 0.016 15.4 1.5 63 4.2 0.1 4.9 4 1 1 5 5 5 0 HEAT repeat DRIM PF07539.12 PIK51840.1 - 0.03 12.6 3.3 0.2 9.9 1.2 2.4 2 1 0 2 2 2 0 Down-regulated in metastasis Peptidase_C101 PF16218.5 PIK51840.1 - 0.056 12.7 0.1 0.056 12.7 0.1 1.8 3 0 0 3 3 3 0 Peptidase family C101 IFRD PF05004.13 PIK51840.1 - 0.071 12.2 0.4 0.21 10.7 0.4 1.8 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) RabGAP-TBC PF00566.18 PIK51843.1 - 1.1e-55 188.6 0.0 2.2e-55 187.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IGF2_C PF08365.11 PIK51843.1 - 0.73 9.9 3.8 0.47 10.5 0.4 2.3 2 0 0 2 2 2 0 Insulin-like growth factor II E-peptide Ank_2 PF12796.7 PIK51844.1 - 3.5e-45 152.5 3.5 1.5e-10 41.5 0.0 6.9 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK51844.1 - 1.9e-34 113.8 9.9 0.0017 18.7 0.0 11.0 11 0 0 11 11 11 7 Ankyrin repeat Ank PF00023.30 PIK51844.1 - 9.5e-33 111.2 10.3 1.7e-05 25.0 0.0 9.4 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 PIK51844.1 - 7.4e-32 109.3 11.2 5.9e-08 33.1 0.6 8.1 4 2 6 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK51844.1 - 6.8e-27 93.2 9.8 1.7e-08 34.6 0.1 8.0 5 2 3 8 8 8 4 Ankyrin repeats (many copies) FYVE PF01363.21 PIK51844.1 - 2.6e-16 59.5 14.4 7e-16 58.1 14.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 PIK51844.1 - 0.54 10.5 12.7 0.074 13.3 8.3 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger DZR PF12773.7 PIK51844.1 - 0.83 9.7 12.5 7.1 6.7 12.5 2.4 1 1 0 1 1 1 0 Double zinc ribbon Ank_2 PF12796.7 PIK51845.1 - 2.2e-40 137.1 11.6 5.5e-11 42.9 0.0 6.5 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 PIK51845.1 - 1.6e-32 110.5 16.0 6.5e-07 29.5 0.0 11.1 12 0 0 12 12 12 8 Ankyrin repeat Ank_4 PF13637.6 PIK51845.1 - 3.1e-31 107.3 9.2 0.00041 20.8 0.0 9.4 5 4 4 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK51845.1 - 5.5e-27 93.5 8.9 4.1e-07 30.1 0.1 7.6 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK51845.1 - 1.4e-25 86.6 11.4 0.0034 17.7 0.1 10.1 12 0 0 12 12 12 7 Ankyrin repeat BTB PF00651.31 PIK51845.1 - 1.1e-15 57.9 0.0 3.1e-15 56.4 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain AnkUBD PF18418.1 PIK51845.1 - 0.0005 20.1 0.3 1.8 8.8 0.0 4.0 4 0 0 4 4 4 1 Ankyrin ubiquitin-binding domain Glyco_transf_10 PF00852.19 PIK51846.1 - 2.6e-51 173.8 0.1 3.9e-51 173.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51846.1 - 3.2e-12 46.9 0.2 7.1e-12 45.8 0.2 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal HGD-D PF06050.13 PIK51846.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component TIP39 PF14980.6 PIK51846.1 - 0.3 11.0 0.0 0.3 11.0 0.0 2.2 3 0 0 3 3 3 0 TIP39 peptide Glyco_transf_10 PF00852.19 PIK51847.1 - 1.6e-49 168.0 0.4 2.9e-49 167.2 0.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51847.1 - 2.9e-07 30.9 0.2 5.6e-07 30.0 0.2 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal HGD-D PF06050.13 PIK51847.1 - 0.0068 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 2-hydroxyglutaryl-CoA dehydratase, D-component Glyco_transf_10 PF00852.19 PIK51848.1 - 4.1e-46 156.9 0.2 7.3e-46 156.1 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51848.1 - 7.4e-09 36.0 0.1 1.7e-08 34.9 0.1 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal RPT PF13446.6 PIK51849.1 - 0.06 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 A repeated domain in UCH-protein Glyco_transf_10 PF00852.19 PIK51850.1 - 4.3e-51 173.1 0.6 5.8e-51 172.7 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 PIK51851.1 - 8.1e-47 159.2 1.0 1.2e-46 158.6 1.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51851.1 - 5.4e-09 36.5 0.3 1.1e-08 35.5 0.3 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK51852.1 - 8.8e-47 159.1 1.1 1.7e-46 158.2 1.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK51852.1 - 1e-09 38.8 0.4 2.5e-09 37.6 0.4 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal PseudoU_synth_2 PF00849.22 PIK51853.1 - 2.1e-24 86.4 0.0 3.8e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Pkinase_Tyr PF07714.17 PIK51854.1 - 2.4e-44 151.6 0.0 7.2e-44 150.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK51854.1 - 2.7e-44 151.5 0.1 4e-44 151.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 PIK51854.1 - 1.7e-05 24.3 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_6 PF17820.1 PIK51854.1 - 0.0001 22.1 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.6 PIK51854.1 - 0.00026 20.4 0.0 0.12 11.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 PIK51854.1 - 0.0017 18.3 0.0 0.0077 16.2 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family PDZ PF00595.24 PIK51854.1 - 0.021 15.2 0.1 0.05 14.0 0.1 1.6 1 0 0 1 1 1 0 PDZ domain Haspin_kinase PF12330.8 PIK51854.1 - 0.06 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 PIK51854.1 - 0.17 11.4 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family LIM PF00412.22 PIK51855.1 - 2.1e-24 85.5 16.7 6.4e-15 55.1 6.8 2.0 2 0 0 2 2 2 2 LIM domain zf-dskA_traR PF01258.17 PIK51855.1 - 0.065 13.2 0.3 0.065 13.2 0.3 3.2 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger RII_binding_1 PF10522.9 PIK51857.1 - 0.11 12.7 1.3 0.31 11.4 1.3 1.7 1 0 0 1 1 1 0 RII binding domain RVT_1 PF00078.27 PIK51858.1 - 3.1e-15 56.3 0.1 3.9e-15 56.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK51859.1 - 3.1e-20 72.5 0.0 5.8e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK51859.1 - 0.028 14.2 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Baculo_LEF-11 PF06385.12 PIK51859.1 - 0.03 14.8 0.2 0.21 12.1 0.0 2.2 2 1 0 2 2 2 0 Baculovirus LEF-11 protein RNA_pol PF00940.19 PIK51860.1 - 0.0054 15.6 0.0 0.0079 15.1 0.0 1.1 1 0 0 1 1 1 1 DNA-dependent RNA polymerase Lipase_GDSL_2 PF13472.6 PIK51860.1 - 0.016 15.6 0.0 0.048 14.1 0.0 1.8 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Y_phosphatase PF00102.27 PIK51861.1 - 1e-48 166.0 1.3 1.4e-48 165.5 1.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RIFIN PF02009.16 PIK51861.1 - 0.0003 20.8 0.0 0.00063 19.7 0.0 1.5 1 0 0 1 1 1 1 Rifin TMEM154 PF15102.6 PIK51861.1 - 0.00066 19.6 2.2 0.00079 19.4 1.1 1.6 1 1 0 1 1 1 1 TMEM154 protein family DUF5305 PF17231.2 PIK51861.1 - 0.0014 18.1 0.3 0.0027 17.1 0.3 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Orf78 PF06024.12 PIK51861.1 - 0.0035 17.6 0.1 0.011 16.0 0.1 1.8 1 0 0 1 1 1 1 Orf78 (ac78) Adeno_E3_CR2 PF02439.15 PIK51861.1 - 0.0035 17.0 5.7 0.0065 16.2 5.7 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Insulin_TMD PF17870.1 PIK51861.1 - 0.0041 17.1 5.4 0.0089 16.1 5.4 1.5 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment fn3 PF00041.21 PIK51861.1 - 0.0052 17.1 0.4 0.057 13.8 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain EphA2_TM PF14575.6 PIK51861.1 - 0.0063 17.4 0.3 0.015 16.1 0.1 1.8 2 0 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 PIK51861.1 - 0.0089 14.9 0.0 0.016 14.0 0.0 1.4 2 0 0 2 2 2 1 Amnionless DUF4448 PF14610.6 PIK51861.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3827 PF12877.7 PIK51861.1 - 0.039 12.4 0.2 0.054 11.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF2207 PF09972.9 PIK51861.1 - 0.046 12.5 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3377 PF11857.8 PIK51861.1 - 0.056 13.4 1.2 0.12 12.3 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Shisa PF13908.6 PIK51861.1 - 0.057 13.7 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ASFV_J13L PF05568.11 PIK51861.1 - 0.11 12.3 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein OSTbeta PF15048.6 PIK51861.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein MRP PF09387.10 PIK51861.1 - 0.16 12.0 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial RNA binding protein MRP Baculo_11_kDa PF06143.11 PIK51861.1 - 0.27 10.9 5.2 0.58 9.8 5.2 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Protocadherin PF08374.11 PIK51861.1 - 3 7.8 5.0 6.4 6.7 5.1 1.6 1 1 0 1 1 1 0 Protocadherin DUF1180 PF06679.12 PIK51861.1 - 4.3 7.7 4.9 1.5 9.3 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) fn3 PF00041.21 PIK51862.1 - 1.5e-06 28.4 1.1 4.3e-06 27.0 1.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF1065 PF06358.11 PIK51862.1 - 0.11 12.5 0.0 0.18 11.7 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1065) NAC PF01849.18 PIK51863.1 - 1.4e-22 79.4 0.0 3.9e-22 78.0 0.0 1.8 1 0 0 1 1 1 1 NAC domain UBA_4 PF14555.6 PIK51863.1 - 0.16 11.8 0.1 0.31 10.9 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain SWI-SNF_Ssr4 PF08549.10 PIK51863.1 - 0.38 9.3 5.2 0.043 12.5 1.1 1.4 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) SEEEED PF14797.6 PIK51863.1 - 4.6 7.4 16.5 0.47 10.6 7.3 2.1 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex Hydrolase_4 PF12146.8 PIK51864.1 - 0.0042 16.4 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Rpr2 PF04032.16 PIK51865.1 - 4.3e-19 68.6 1.4 8.2e-19 67.7 1.4 1.4 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain SIR2 PF02146.17 PIK51865.1 - 0.0086 16.0 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 Sir2 family Peptidase_M44 PF03410.13 PIK51865.1 - 0.0093 14.6 0.1 0.0093 14.6 0.1 1.0 1 0 0 1 1 1 1 Metallopeptidase from vaccinia pox ADD_ATRX PF17981.1 PIK51865.1 - 0.016 15.1 2.7 2.4 8.1 0.4 2.4 2 0 0 2 2 2 0 Cysteine Rich ADD domain zf-C2H2_3 PF13878.6 PIK51865.1 - 0.3 11.0 5.9 0.6 10.0 0.2 3.1 2 1 1 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-CCCH PF00642.24 PIK51866.1 - 1.4e-12 47.1 35.5 1.7e-05 24.6 0.3 5.4 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK51866.1 - 2.7e-12 46.3 50.2 9.4e-07 28.7 1.7 6.2 5 1 0 5 5 5 5 Zinc finger domain Torus PF16131.5 PIK51866.1 - 8.7e-11 42.5 28.6 0.00025 21.7 0.5 5.3 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.5 PIK51866.1 - 2e-10 40.9 25.3 2.5e-08 34.1 10.7 2.6 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCHC PF00098.23 PIK51866.1 - 7.9e-06 25.7 13.2 0.00046 20.1 4.2 3.8 4 0 0 4 4 4 2 Zinc knuckle zf-CCCH_4 PF18044.1 PIK51866.1 - 2.9e-05 23.8 0.3 2.9e-05 23.8 0.3 5.0 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 PIK51866.1 - 0.0021 18.4 51.1 0.054 14.0 1.1 6.1 6 0 0 6 6 6 3 RNA-binding, Nab2-type zinc finger zf-CCHC_3 PF13917.6 PIK51866.1 - 0.0027 17.6 4.6 0.65 10.0 0.5 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK51866.1 - 0.036 13.8 2.0 0.036 13.8 2.0 3.3 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 PIK51866.1 - 0.046 13.5 7.1 1.2 8.9 0.1 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-C3H1 PF10650.9 PIK51866.1 - 0.057 13.2 0.4 0.057 13.2 0.4 5.5 6 0 0 6 6 6 0 Putative zinc-finger domain zf-C2H2_10 PF16588.5 PIK51866.1 - 0.55 10.0 14.2 0.38 10.5 1.8 3.0 2 0 0 2 2 2 0 C2H2 zinc-finger ANAPC10 PF03256.16 PIK51867.1 - 6.9e-15 55.2 0.8 1.6e-14 53.9 0.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK51867.1 - 0.00013 22.1 0.0 0.00033 20.8 0.0 1.7 1 0 0 1 1 1 1 F5/8 type C domain TRPM_tetra PF16519.5 PIK51867.1 - 0.029 14.5 0.0 0.12 12.5 0.0 2.0 1 0 0 1 1 1 0 Tetramerisation domain of TRPM CUB PF00431.20 PIK51867.1 - 0.065 13.6 0.4 0.38 11.1 0.2 2.4 2 0 0 2 2 2 0 CUB domain CheD PF03975.13 PIK51867.1 - 0.15 12.2 0.0 0.42 10.7 0.0 1.8 1 1 0 1 1 1 0 CheD chemotactic sensory transduction NERD PF08378.11 PIK51869.1 - 1.1e-13 51.5 0.0 1.7e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Nuclease-related domain Hjc PF01870.18 PIK51869.1 - 8.4e-05 22.5 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) DNA_pol_E_B PF04042.16 PIK51870.1 - 2.7e-41 141.3 0.0 3.6e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 PIK51870.1 - 1.4e-22 80.2 0.1 3e-22 79.1 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain LLGL PF08366.13 PIK51871.1 - 1.2e-20 73.8 0.0 2.5e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 LLGL2 WD40 PF00400.32 PIK51871.1 - 0.00023 21.9 3.2 0.12 13.2 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Lgl_C PF08596.10 PIK51871.1 - 0.0022 16.8 0.0 0.0043 15.8 0.0 1.4 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 PIK51871.1 - 0.01 16.2 0.0 0.32 11.3 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain RBD-FIP PF09457.10 PIK51872.1 - 1.6e-09 37.5 0.9 1.6e-09 37.5 0.9 2.2 2 0 0 2 2 2 1 FIP domain bZIP_1 PF00170.21 PIK51872.1 - 0.0036 17.4 0.3 0.0036 17.4 0.3 1.9 2 1 0 2 2 2 1 bZIP transcription factor DivIC PF04977.15 PIK51872.1 - 0.0042 16.8 0.9 0.0042 16.8 0.9 1.9 2 0 0 2 2 2 1 Septum formation initiator WD40_alt PF14077.6 PIK51872.1 - 0.0056 16.5 0.2 0.083 12.8 0.0 2.2 2 0 0 2 2 2 1 Alternative WD40 repeat motif DUF445 PF04286.12 PIK51872.1 - 0.0078 16.1 2.2 0.0093 15.8 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF445) A_thal_3526 PF09713.10 PIK51872.1 - 0.0097 16.1 0.2 0.0097 16.1 0.2 1.9 2 0 0 2 2 2 1 Plant protein 1589 of unknown function (A_thal_3526) CENP-H PF05837.12 PIK51872.1 - 0.01 16.2 5.9 0.02 15.3 5.7 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TolA_bind_tri PF16331.5 PIK51872.1 - 0.011 15.7 1.3 0.017 15.2 0.5 1.7 2 0 0 2 2 2 0 TolA binding protein trimerisation JIP_LZII PF16471.5 PIK51872.1 - 0.016 15.4 2.7 0.016 15.4 2.7 2.5 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II STAT_alpha PF01017.20 PIK51872.1 - 0.017 15.0 3.9 0.023 14.6 3.9 1.1 1 0 0 1 1 1 0 STAT protein, all-alpha domain ZapB PF06005.12 PIK51872.1 - 0.017 15.5 9.8 0.05 14.1 9.8 1.7 1 1 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 PIK51872.1 - 0.025 14.6 2.7 0.025 14.6 2.7 1.7 2 0 0 2 2 2 0 Basic region leucine zipper NOG1_N PF17835.1 PIK51872.1 - 0.055 13.4 0.9 0.14 12.1 0.1 1.8 1 1 1 2 2 2 0 NOG1 N-terminal helical domain H-kinase_dim PF02895.14 PIK51872.1 - 0.058 13.8 1.9 8 6.9 0.1 2.3 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain YabA PF06156.13 PIK51872.1 - 0.062 13.9 6.1 0.073 13.7 3.6 1.9 1 1 1 2 2 2 0 Initiation control protein YabA FlaC_arch PF05377.11 PIK51872.1 - 0.13 12.7 0.6 0.13 12.7 0.6 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) VPS11_C PF12451.8 PIK51872.1 - 0.14 12.4 1.7 1.7 8.9 1.2 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal DASH_Dam1 PF08653.10 PIK51872.1 - 0.22 11.4 0.8 0.54 10.1 0.4 1.9 2 0 0 2 2 2 0 DASH complex subunit Dam1 V_ATPase_I PF01496.19 PIK51872.1 - 0.37 8.6 3.0 0.42 8.5 3.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIVA PF05103.13 PIK51872.1 - 0.4 10.8 5.9 1.7 8.8 6.4 1.6 1 1 1 2 2 2 0 DivIVA protein betaPIX_CC PF16523.5 PIK51872.1 - 0.45 10.4 8.3 3.8 7.4 1.3 2.3 1 1 0 2 2 2 0 betaPIX coiled coil LMBR1 PF04791.16 PIK51872.1 - 0.49 9.2 1.3 0.55 9.1 1.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PRKG1_interact PF15898.5 PIK51872.1 - 0.75 10.7 8.9 0.72 10.8 1.2 2.2 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain PikAIV_N PF18605.1 PIK51872.1 - 3.1 7.5 5.8 0.63 9.7 1.1 2.3 3 0 0 3 3 3 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain DUF4472 PF14739.6 PIK51873.1 - 0.00016 22.3 21.1 0.016 15.9 8.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4472) CENP-F_leu_zip PF10473.9 PIK51873.1 - 0.00033 20.7 29.8 0.013 15.6 15.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CtIP_N PF10482.9 PIK51873.1 - 0.0018 18.3 13.3 0.0018 18.3 13.3 2.1 1 1 1 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain ADIP PF11559.8 PIK51873.1 - 0.003 17.7 24.9 0.081 13.0 7.6 2.3 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 PIK51873.1 - 0.0091 14.9 24.1 0.014 14.3 24.1 1.4 1 1 0 1 1 1 1 Spc7 kinetochore protein ABC_tran_CTD PF16326.5 PIK51873.1 - 0.0091 16.2 3.8 0.0091 16.2 3.8 3.5 2 1 1 3 3 2 1 ABC transporter C-terminal domain TPR_MLP1_2 PF07926.12 PIK51873.1 - 0.012 15.6 11.5 0.012 15.6 11.5 3.5 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.7 PIK51873.1 - 0.016 15.4 31.1 0.38 10.9 18.0 2.6 1 1 1 2 2 2 0 Tropomyosin like DUF4164 PF13747.6 PIK51873.1 - 0.028 14.7 6.0 0.028 14.7 6.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Rootletin PF15035.6 PIK51873.1 - 0.033 14.2 25.6 0.15 12.0 25.6 1.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4315 PF14193.6 PIK51873.1 - 0.04 13.9 0.4 0.04 13.9 0.4 3.8 4 1 0 4 4 4 0 Domain of unknown function (DUF4315) DUF4686 PF15742.5 PIK51873.1 - 0.064 12.4 27.8 0.073 12.2 27.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) SUZ PF12752.7 PIK51873.1 - 0.068 13.9 5.3 0.075 13.8 1.5 2.4 2 0 0 2 2 2 0 SUZ domain Fez1 PF06818.15 PIK51873.1 - 0.1 13.1 23.2 0.094 13.2 4.6 2.1 1 1 1 2 2 2 0 Fez1 Syntaxin-6_N PF09177.11 PIK51873.1 - 0.11 13.1 0.9 0.11 13.1 0.9 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal KASH_CCD PF14662.6 PIK51873.1 - 0.11 12.3 28.3 1.8 8.4 28.3 2.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF724 PF05266.14 PIK51873.1 - 0.11 12.3 20.1 0.21 11.4 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 PIK51873.1 - 0.14 12.3 25.9 0.31 11.3 10.2 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Taxilin PF09728.9 PIK51873.1 - 0.16 11.2 27.6 0.75 8.9 27.6 1.8 1 1 0 1 1 1 0 Myosin-like coiled-coil protein APC_u5 PF16630.5 PIK51873.1 - 0.16 13.0 2.6 0.2 12.7 1.6 1.8 1 1 0 1 1 1 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs FliD_C PF07195.12 PIK51873.1 - 0.27 10.6 13.7 0.5 9.7 1.1 2.5 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus TelA PF05816.11 PIK51873.1 - 0.28 10.2 15.5 0.18 10.9 13.4 1.6 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) Snf7 PF03357.21 PIK51873.1 - 0.3 10.7 17.6 0.62 9.6 17.6 1.6 1 1 0 1 1 1 0 Snf7 bZIP_1 PF00170.21 PIK51873.1 - 0.34 11.0 24.3 1 9.5 0.5 4.3 1 1 3 4 4 4 0 bZIP transcription factor DUF3209 PF11483.8 PIK51873.1 - 0.51 10.8 11.0 0.17 12.4 7.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3209) Leu_zip PF15294.6 PIK51873.1 - 0.82 9.1 21.6 1.7 8.1 21.6 1.6 1 1 0 1 1 1 0 Leucine zipper NPV_P10 PF05531.12 PIK51873.1 - 0.88 10.1 7.9 15 6.1 1.9 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein UPF0242 PF06785.11 PIK51873.1 - 0.89 9.6 29.8 2.3 8.3 12.3 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HALZ PF02183.18 PIK51873.1 - 0.98 9.7 21.8 0.22 11.8 6.6 3.9 2 2 2 4 4 3 0 Homeobox associated leucine zipper YabA PF06156.13 PIK51873.1 - 1.1 10.0 20.3 2.3 8.9 6.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA ATG16 PF08614.11 PIK51873.1 - 1.4 9.1 27.1 1.5 9.0 22.6 2.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 PIK51873.1 - 1.5 8.1 14.8 13 5.1 14.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ERM PF00769.19 PIK51873.1 - 1.6 8.5 28.8 18 5.1 28.8 2.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Baculo_PEP_C PF04513.12 PIK51873.1 - 1.7 8.7 6.5 4.1 7.4 5.3 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.12 PIK51873.1 - 1.8 7.0 5.8 1.9 6.9 5.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Metal_resist PF13801.6 PIK51873.1 - 1.8 8.8 8.8 11 6.2 8.9 2.0 1 1 0 1 1 1 0 Heavy-metal resistance bZIP_Maf PF03131.17 PIK51873.1 - 1.9 9.1 22.8 0.41 11.2 3.0 3.5 1 1 2 3 3 3 0 bZIP Maf transcription factor Ax_dynein_light PF10211.9 PIK51873.1 - 2.1 8.3 24.1 4.2 7.3 12.8 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain PI3K_P85_iSH2 PF16454.5 PIK51873.1 - 2.1 7.9 25.6 1.5 8.4 6.1 3.2 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 PIK51873.1 - 2.7 8.0 11.5 3.7 7.6 4.7 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 PIK51873.1 - 2.8 7.0 20.0 3.4 6.7 19.1 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 PIK51873.1 - 2.9 7.3 27.3 0.48 9.8 8.2 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Gp58 PF07902.11 PIK51873.1 - 3.7 5.7 9.1 16 3.6 9.1 1.8 1 1 0 1 1 1 0 gp58-like protein Fib_alpha PF08702.10 PIK51873.1 - 4.4 7.5 16.4 1.6 8.9 12.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 PIK51873.1 - 4.4 6.6 28.9 4 6.7 13.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 PIK51873.1 - 5.7 6.2 23.3 4.3 6.6 12.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) OmpH PF03938.14 PIK51873.1 - 7.5 6.9 24.5 6.3 7.1 11.0 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Fmp27_WPPW PF10359.9 PIK51873.1 - 7.5 5.3 19.1 24 3.6 18.6 1.8 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain fn3 PF00041.21 PIK51875.1 - 8.8e-28 96.5 1.3 3.3e-13 49.8 0.2 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK51875.1 - 1.9e-10 41.2 0.4 1.9e-05 25.2 0.0 2.4 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK51875.1 - 0.00015 22.0 0.0 0.27 11.6 0.0 2.4 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III GPI-anchored PF10342.9 PIK51875.1 - 0.022 15.5 2.5 2.2 9.1 0.1 3.1 3 1 0 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family fn3 PF00041.21 PIK51876.1 - 0.00091 19.5 0.0 0.0019 18.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF3884 PF13024.6 PIK51877.1 - 0.05 13.2 0.1 8.1 6.1 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3884) 2-Hacid_dh PF00389.30 PIK51878.1 - 5e-34 116.8 0.1 5.8e-34 116.6 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 PIK51878.1 - 2e-16 59.9 0.1 3.9e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 PIK51878.1 - 0.066 13.6 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 PIK51879.1 - 5e-33 113.9 0.0 9.3e-33 113.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK51879.1 - 0.00054 19.6 0.0 0.00087 19.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain LRRFIP PF09738.9 PIK51880.1 - 2e-73 247.4 49.7 2e-73 247.4 49.7 2.1 2 0 0 2 2 2 1 LRRFIP family Macoilin PF09726.9 PIK51880.1 - 0.0056 15.3 9.9 0.0056 15.3 9.9 3.1 1 1 1 3 3 3 1 Macoilin family APG6_N PF17675.1 PIK51880.1 - 0.007 16.9 24.1 0.007 16.9 24.1 4.1 2 2 2 4 4 4 2 Apg6 coiled-coil region DUF641 PF04859.12 PIK51880.1 - 0.017 15.5 9.7 0.017 15.5 9.7 4.5 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) HALZ PF02183.18 PIK51880.1 - 0.034 14.4 32.0 0.38 11.0 0.8 5.8 4 1 1 5 5 5 0 Homeobox associated leucine zipper Surfac_D-trimer PF09006.11 PIK51880.1 - 0.45 10.5 0.1 0.45 10.5 0.1 3.1 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation DUF1664 PF07889.12 PIK51880.1 - 0.49 10.4 29.7 0.69 10.0 2.7 4.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) RAWUL PF16207.5 PIK51881.1 - 2.5e-12 47.3 0.0 4.2e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like UPF0370 PF13980.6 PIK51881.1 - 0.091 12.8 0.6 0.75 9.9 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) RAWUL PF16207.5 PIK51882.1 - 5.2e-17 62.3 0.0 1.1e-16 61.2 0.0 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 PIK51882.1 - 6e-10 38.8 10.7 1.4e-09 37.6 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK51882.1 - 3.6e-08 33.2 10.5 3.6e-08 33.2 10.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK51882.1 - 1.1e-05 25.7 9.8 1.1e-05 25.7 9.8 1.6 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.6 PIK51882.1 - 0.00018 21.4 10.0 0.00018 21.4 10.0 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK51882.1 - 0.00025 20.8 7.5 0.00025 20.8 7.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 PIK51882.1 - 0.00091 19.1 4.6 0.0017 18.2 4.6 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 PIK51882.1 - 0.0023 17.9 8.0 0.0023 17.9 8.0 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 PIK51882.1 - 0.0073 16.6 6.7 0.017 15.4 6.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 PIK51882.1 - 0.011 15.9 11.5 0.02 15.1 9.6 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 PIK51882.1 - 0.21 11.7 1.4 0.45 10.7 1.4 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 PIK51882.1 - 0.96 9.4 11.4 0.22 11.4 8.0 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 PIK51882.1 - 1.3 8.9 7.7 0.36 10.7 3.9 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 PIK51882.1 - 1.4 8.7 9.1 0.51 10.2 5.8 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 PIK51882.1 - 2.8 8.2 13.8 0.26 11.4 8.5 2.0 3 0 0 3 3 2 0 zinc RING finger of MSL2 IBR PF01485.21 PIK51882.1 - 3.6 7.9 9.2 92 3.4 7.8 3.1 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain RAWUL PF16207.5 PIK51883.1 - 6.7e-17 61.9 0.0 1.3e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like TGF_beta PF00019.20 PIK51884.1 - 6e-25 88.2 1.5 9.7e-25 87.6 1.5 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain FAO_M PF16350.5 PIK51885.1 - 1.1e-06 28.9 1.5 6.4 7.2 0.0 4.4 1 1 3 4 4 4 2 FAD dependent oxidoreductase central domain Sigma70_r1_2 PF00140.20 PIK51885.1 - 2.8e-05 24.0 0.2 30 4.7 0.0 4.4 4 0 0 4 4 4 0 Sigma-70 factor, region 1.2 SAM_2 PF07647.17 PIK51885.1 - 0.0002 21.4 2.8 7.1 6.8 0.0 4.7 1 1 4 5 5 5 1 SAM domain (Sterile alpha motif) Steroid_dh PF02544.16 PIK51885.1 - 0.0017 18.3 0.1 15 5.5 0.0 3.8 3 1 0 4 4 4 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF4974 PF16344.5 PIK51885.1 - 0.0076 16.2 8.9 39 4.3 0.1 5.2 2 1 3 5 5 5 0 Domain of unknown function (DUF4974) Miga PF10265.9 PIK51885.1 - 0.039 12.9 4.6 10 4.9 0.0 3.9 4 0 0 4 4 4 0 Mitoguardin Phage_tail_APC PF16778.5 PIK51885.1 - 0.059 13.2 1.8 95 3.0 0.0 4.0 4 0 0 4 4 4 0 Phage tail assembly chaperone protein TetR_C_8 PF14278.6 PIK51885.1 - 0.16 12.1 6.9 53 4.0 0.2 4.1 1 1 3 4 4 4 0 Transcriptional regulator C-terminal region MKLP1_Arf_bdg PF16540.5 PIK51885.1 - 0.48 10.5 9.0 11 6.2 0.5 4.0 1 1 3 4 4 4 0 Arf6-interacting domain of mitotic kinesin-like protein 1 PAS_6 PF08348.11 PIK51885.1 - 1.4 8.8 6.3 12 5.8 0.2 3.5 1 1 3 4 4 4 0 YheO-like PAS domain 7tm_1 PF00001.21 PIK51887.1 - 1.1e-40 139.6 17.6 1.6e-40 139.1 17.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK51887.1 - 1.2e-12 48.0 10.3 1.2e-12 48.0 10.3 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK51887.1 - 3e-07 30.1 9.5 4.9e-07 29.4 9.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK51887.1 - 0.00087 18.7 8.0 0.0011 18.4 7.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK51887.1 - 0.061 13.0 15.8 0.46 10.2 15.8 2.5 1 1 0 1 1 1 0 Olfactory receptor DUF2105 PF09878.9 PIK51887.1 - 4.9 6.8 10.8 0.4 10.4 4.4 2.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2105) DUF4205 PF13898.6 PIK51888.1 - 3.7e-52 177.4 0.0 4.8e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) EF-hand_6 PF13405.6 PIK51888.1 - 0.0072 16.2 0.0 0.03 14.2 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 PIK51888.1 - 0.042 13.4 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 EF hand DUF4539 PF15072.6 PIK51890.1 - 2.2e-28 98.1 0.2 3.9e-28 97.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) tRNA_anti-codon PF01336.25 PIK51890.1 - 0.08 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Transglut_core PF01841.19 PIK51891.1 - 6.7e-06 26.5 0.0 1.4e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily SHIPPO-rpt PF07004.12 PIK51891.1 - 0.054 14.4 0.1 0.16 13.0 0.1 1.8 1 0 0 1 1 1 0 Sperm-tail PG-rich repeat NPL PF17800.1 PIK51892.1 - 5.3e-13 49.4 0.0 5.3e-13 49.4 0.0 2.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain zf-C2H2 PF00096.26 PIK51892.1 - 7.7e-09 35.5 28.5 0.0045 17.4 2.4 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK51892.1 - 8.7e-09 35.4 0.5 8.7e-09 35.4 0.5 5.5 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK51892.1 - 1.2e-07 31.9 25.5 0.039 14.8 0.1 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger PyrI_C PF02748.15 PIK51892.1 - 0.0053 16.6 8.6 1.4 8.9 0.4 3.6 3 0 0 3 3 3 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_8 PF15909.5 PIK51892.1 - 0.029 14.7 0.3 0.029 14.7 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc ribbon UBZ_FAAP20 PF15750.5 PIK51892.1 - 0.27 11.2 1.6 28 4.8 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger C1_4 PF07975.12 PIK51892.1 - 0.79 10.0 12.1 11 6.3 1.2 3.7 2 2 2 4 4 4 0 TFIIH C1-like domain NADH_B2 PF14813.6 PIK51893.1 - 7.8e-29 99.3 0.8 9.7e-29 99.0 0.8 1.1 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Aldo_ket_red PF00248.21 PIK51894.1 - 1.9e-69 234.1 0.0 2.7e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family EGF PF00008.27 PIK51895.1 - 9.3e-17 61.0 96.1 8.7e-07 29.1 5.5 8.2 7 1 0 7 7 7 4 EGF-like domain VWD PF00094.25 PIK51895.1 - 8.3e-09 35.9 1.0 1.2e-08 35.4 0.1 1.7 2 0 0 2 2 2 1 von Willebrand factor type D domain hEGF PF12661.7 PIK51895.1 - 3.2e-06 27.5 21.0 0.00012 22.5 4.7 9.9 9 1 2 11 11 11 4 Human growth factor-like EGF RVT_1 PF00078.27 PIK51895.1 - 0.0012 18.5 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_2 PF07974.13 PIK51895.1 - 0.012 15.9 10.2 0.012 15.9 10.2 8.4 8 1 0 8 8 8 0 EGF-like domain Ig_3 PF13927.6 PIK51895.1 - 0.052 14.2 0.2 0.052 14.2 0.2 2.2 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK51895.1 - 1.6 8.8 3.2 1.3 9.1 0.2 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain VWD PF00094.25 PIK51896.1 - 3.1e-40 138.0 7.1 6.6e-23 81.7 0.9 3.2 2 1 1 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 PIK51896.1 - 3.4e-24 85.0 10.0 6.2e-15 55.4 3.2 5.1 4 2 1 5 5 5 2 C8 domain TILa PF12714.7 PIK51896.1 - 1.8e-14 53.4 23.9 7.9e-09 35.3 10.1 6.1 5 2 1 6 6 6 2 TILa domain TIL PF01826.17 PIK51896.1 - 6.3e-07 29.6 9.2 6.3e-07 29.6 9.2 8.1 4 2 2 7 7 7 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK51896.1 - 9.3e-05 22.5 23.1 0.00078 19.6 10.8 6.6 6 0 0 6 6 6 2 EGF domain Fibrinogen_C PF00147.18 PIK51897.1 - 2e-44 152.0 8.8 4.8e-44 150.8 8.8 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain VWD PF00094.25 PIK51897.1 - 1.1e-36 126.4 0.0 5.5e-17 62.5 0.0 3.5 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 PIK51897.1 - 3.5e-21 75.4 15.5 2.1e-12 47.3 0.4 6.7 5 1 0 6 6 6 3 C8 domain TIL PF01826.17 PIK51897.1 - 3.9e-18 65.5 62.8 2.7e-08 33.9 19.6 7.9 6 2 1 7 7 7 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK51897.1 - 9.5e-09 35.1 20.6 1.8e-06 27.8 10.1 8.1 6 2 1 7 7 7 3 TILa domain zf-Di19 PF05605.12 PIK51898.1 - 6.5 7.1 6.5 33 4.9 1.0 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Transposase_24 PF03004.14 PIK51898.1 - 8.6 6.5 16.1 0.85 9.7 0.1 4.1 2 1 1 4 4 4 0 Plant transposase (Ptta/En/Spm family) Sushi PF00084.20 PIK51899.1 - 5.7e-19 68.5 10.2 3.3e-07 30.8 0.4 3.3 2 1 1 3 3 3 3 Sushi repeat (SCR repeat) DUF281 PF03436.13 PIK51899.1 - 0.022 15.2 0.3 0.2 12.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF281) HRM PF02793.22 PIK51899.1 - 1.3 9.4 7.2 1.3 9.3 0.1 3.3 3 0 0 3 3 3 0 Hormone receptor domain Gal-3-0_sulfotr PF06990.11 PIK51900.1 - 1.9e-45 155.4 0.3 2.3e-45 155.2 0.3 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK51900.1 - 0.064 13.6 0.1 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 Sulfotransferase family Fibrinogen_C PF00147.18 PIK51901.1 - 4.4e-64 216.3 9.3 5.3e-64 216.0 9.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK51902.1 - 1.9e-26 92.9 0.1 3e-26 92.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK51902.1 - 8.6e-05 22.5 0.0 0.00034 20.6 0.1 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK51903.1 - 3.3e-21 75.1 1.3 7.8e-21 73.9 1.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK51903.1 - 5.5e-19 68.5 0.0 1.7e-18 66.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain SCAN PF02023.17 PIK51903.1 - 2.1e-07 30.7 0.3 6e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 SCAN domain zf-C2H2_10 PF16588.5 PIK51903.1 - 4.6e-05 23.1 1.5 9.4e-05 22.0 1.5 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger zf-H2C2 PF09337.10 PIK51903.1 - 6.5e-05 23.1 0.4 0.00015 21.9 0.4 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK51903.1 - 0.049 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.23 PIK51903.1 - 0.37 11.0 4.5 0.6 10.3 1.1 2.4 2 0 0 2 2 2 0 Zinc knuckle Fibrinogen_C PF00147.18 PIK51904.1 - 6.1e-47 160.3 3.1 8.8e-35 120.5 0.5 2.4 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK51904.1 - 2.8e-06 27.4 9.9 2.8e-06 27.4 9.9 4.1 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK51904.1 - 7.8e-05 22.5 5.6 7.8e-05 22.5 5.6 3.1 2 1 1 3 3 3 1 TILa domain EGF_2 PF07974.13 PIK51904.1 - 0.81 10.1 27.3 0.072 13.5 8.8 4.3 2 2 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK51905.1 - 1.2e-37 129.9 1.6 1.9e-37 129.2 1.6 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK51905.1 - 2.6e-05 24.3 3.5 2.6e-05 24.3 3.5 2.5 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK51905.1 - 3.5e-05 23.7 4.4 7.3e-05 22.6 2.1 2.6 2 0 0 2 2 2 1 TILa domain SCRL PF06876.12 PIK51905.1 - 1.2 9.4 7.4 1.4 9.2 1.1 2.2 1 1 1 2 2 2 0 Plant self-incompatibility response (SCRL) protein Fibrinogen_C PF00147.18 PIK51906.1 - 1.3e-43 149.4 0.6 1.6e-43 149.1 0.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51907.1 - 4.2e-53 180.4 8.3 5.2e-53 180.1 8.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51908.1 - 1.1e-28 100.5 1.8 1.4e-28 100.2 1.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51909.1 - 1e-06 28.8 0.0 1.3e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Phosphodiest PF01663.22 PIK51910.1 - 4.5e-59 200.8 0.5 5.3e-59 200.6 0.5 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 PIK51910.1 - 3.3e-09 36.6 0.3 0.0022 17.4 0.1 2.8 3 0 0 3 3 3 2 Sulfatase PglZ PF08665.12 PIK51910.1 - 0.0069 16.5 0.0 0.043 13.9 0.0 2.1 2 0 0 2 2 2 1 PglZ domain VWA_CoxE PF05762.14 PIK51910.1 - 0.12 11.8 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein DUF2684 PF10885.8 PIK51910.1 - 0.17 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2684) SMN PF06003.12 PIK51912.1 - 1e-56 192.1 6.1 1.2e-56 191.9 6.1 1.0 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) 4F5 PF04419.14 PIK51913.1 - 1.6e-05 25.6 11.7 1.6e-05 25.6 11.7 2.2 2 0 0 2 2 2 1 4F5 protein family CAML PF14963.6 PIK51913.1 - 2.4 8.2 6.9 3 7.9 6.9 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DAP3 PF10236.9 PIK51914.1 - 3.8e-50 170.8 0.6 5e-50 170.4 0.1 1.3 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 ATPase_2 PF01637.18 PIK51914.1 - 0.00045 20.2 0.0 0.00068 19.6 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF3391 PF11871.8 PIK51914.1 - 0.017 15.6 0.1 8.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) cobW PF02492.19 PIK51914.1 - 0.052 13.1 0.0 1.7 8.2 0.0 2.6 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 PIK51914.1 - 0.095 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B fn3 PF00041.21 PIK51915.1 - 3.4e-35 120.2 13.2 3.8e-12 46.4 0.6 5.3 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK51915.1 - 5.5e-07 30.1 18.8 0.0045 17.5 0.9 5.6 4 2 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK51915.1 - 1.3e-06 28.5 2.6 0.49 10.6 0.0 4.5 3 1 1 4 4 4 3 Fibronectin type III domain Y_Y_Y PF07495.13 PIK51915.1 - 0.00058 19.8 9.6 1.2 9.2 1.0 4.3 3 2 0 3 3 3 3 Y_Y_Y domain DUF2369 PF10179.9 PIK51915.1 - 0.0045 17.4 1.3 0.15 12.5 0.0 3.4 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 PIK51915.1 - 0.054 13.8 7.1 0.23 11.8 0.1 3.6 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III fn3_4 PF16794.5 PIK51915.1 - 0.079 12.9 0.0 10 6.1 0.0 3.6 2 1 0 2 2 2 0 Fibronectin-III type domain DUF1410 PF07198.11 PIK51915.1 - 2.9 8.5 5.8 13 6.4 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1410) GPI-anchored PF10342.9 PIK51915.1 - 3.8 8.3 8.5 21 5.9 0.1 4.4 3 2 1 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SlyX PF04102.12 PIK51916.1 - 0.001 19.6 2.2 0.0024 18.4 1.3 1.9 2 0 0 2 2 2 1 SlyX TACC_C PF05010.14 PIK51916.1 - 0.0014 18.5 0.3 0.0022 17.8 0.3 1.4 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ATF7IP_BD PF16788.5 PIK51916.1 - 0.018 15.2 2.4 0.24 11.4 3.0 2.1 1 1 1 2 2 2 0 ATF-interacting protein binding domain SWI-SNF_Ssr4 PF08549.10 PIK51916.1 - 0.049 12.3 1.3 0.061 12.0 1.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) FlaC_arch PF05377.11 PIK51916.1 - 0.063 13.7 2.6 0.48 10.8 0.6 2.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Med4 PF10018.9 PIK51916.1 - 0.077 12.7 1.1 0.11 12.2 1.1 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 XhlA PF10779.9 PIK51916.1 - 0.12 12.6 1.8 0.31 11.3 1.6 1.8 1 1 0 1 1 1 0 Haemolysin XhlA Prefoldin PF02996.17 PIK51916.1 - 0.21 11.5 3.8 0.18 11.7 2.0 1.8 2 1 0 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.8 PIK51916.1 - 0.44 10.6 5.9 0.47 10.5 2.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF16 PF01519.16 PIK51916.1 - 2.7 8.5 7.0 0.36 11.3 2.6 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 ADIP PF11559.8 PIK51916.1 - 8.2 6.5 10.3 0.98 9.5 6.2 1.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ASCH PF04266.14 PIK51917.1 - 6.8e-17 62.0 0.0 1.8e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.13 PIK51917.1 - 2.5e-11 43.4 11.6 4.5e-11 42.6 11.6 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-UBP PF02148.19 PIK51917.1 - 1.9 8.9 8.3 34 4.9 4.5 3.1 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein APG5 PF04106.12 PIK51918.1 - 0.00077 19.1 0.2 0.00091 18.9 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 PP1_inhibitor PF05361.12 PIK51918.1 - 0.023 14.7 0.0 0.033 14.2 0.0 1.4 1 1 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor BAF PF02961.14 PIK51918.1 - 0.05 14.0 0.1 0.21 12.0 0.0 2.0 2 1 0 2 2 2 0 Barrier to autointegration factor WD40_3 PF15911.5 PIK51918.1 - 0.088 12.8 0.0 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF3668 PF12416.8 PIK51919.1 - 1.8e-67 227.4 0.0 6.3e-67 225.7 0.0 2.0 1 0 0 1 1 1 1 Cep120 protein C2 PF00168.30 PIK51919.1 - 0.00034 20.9 0.0 1.7 9.0 0.0 3.7 3 0 0 3 3 3 2 C2 domain DUF4497 PF14924.6 PIK51919.1 - 0.003 18.0 0.1 0.1 13.0 0.0 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF4497) Fibrinogen_C PF00147.18 PIK51921.1 - 2.1e-34 119.3 1.0 4.1e-34 118.3 1.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK51921.1 - 5.1e-06 26.6 14.7 5.1e-06 26.6 14.7 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK51921.1 - 5.5e-06 26.2 16.7 5.5e-06 26.2 16.7 3.0 3 1 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK51921.1 - 1.5e-05 25.1 7.1 1.5e-05 25.1 7.1 4.9 3 2 2 5 5 5 1 EGF domain EGF_MSP1_1 PF12946.7 PIK51921.1 - 0.27 11.3 25.9 0.19 11.8 3.8 3.6 3 0 0 3 3 3 0 MSP1 EGF domain 1 zf-CCHC PF00098.23 PIK51922.1 - 2.6e-07 30.4 14.9 0.00032 20.6 2.8 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK51922.1 - 0.0039 16.9 15.1 0.057 13.2 1.2 2.8 2 1 1 3 3 3 2 Zinc knuckle CLIP1_ZNF PF16641.5 PIK51922.1 - 0.016 15.1 8.8 0.47 10.4 0.2 2.6 2 0 0 2 2 2 0 CLIP1 zinc knuckle zf-CCHC_6 PF15288.6 PIK51922.1 - 0.34 10.8 17.7 3.5 7.5 4.5 3.5 2 1 1 3 3 3 0 Zinc knuckle TIL PF01826.17 PIK51923.1 - 1.4e-07 31.7 17.5 1.4e-07 31.7 17.5 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK51923.1 - 3.3e-05 24.0 9.7 3.3e-05 24.0 9.7 4.0 3 2 0 3 3 3 1 EGF domain EGF PF00008.27 PIK51923.1 - 0.0032 17.7 4.4 0.0032 17.7 4.4 4.4 5 1 0 5 5 5 1 EGF-like domain Fibrinogen_C PF00147.18 PIK51923.1 - 0.019 14.8 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain DUF2220 PF09983.9 PIK51924.1 - 0.076 12.4 0.1 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Fibrinogen_C PF00147.18 PIK51926.1 - 1.6e-37 129.4 6.3 2e-37 129.2 6.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK51927.1 - 1e-07 32.1 17.1 1.6e-07 31.4 17.1 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Resistin PF06954.11 PIK51927.1 - 0.59 10.7 12.1 0.56 10.8 9.3 2.5 1 1 0 1 1 1 0 Resistin Fibrinogen_C PF00147.18 PIK51928.1 - 1.3e-38 133.0 5.5 1.5e-38 132.8 5.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK51929.1 - 4.9e-23 82.1 1.5 5.3e-23 82.0 1.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FBA_1 PF07734.13 PIK51929.1 - 0.054 13.4 0.0 0.054 13.4 0.0 1.1 1 0 0 1 1 1 0 F-box associated UCH PF00443.29 PIK51930.1 - 2.4e-29 102.6 0.0 3.5e-28 98.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK51930.1 - 7.4e-10 38.9 0.3 2.2e-05 24.2 0.2 2.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 PIK51930.1 - 6.9e-05 22.5 0.1 0.00022 20.9 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family Peptidase_C98 PF15499.6 PIK51930.1 - 0.057 12.9 0.4 0.33 10.4 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase HTH_WhiA PF02650.14 PIK51931.1 - 0.03 14.6 0.1 0.067 13.5 0.1 1.7 1 0 0 1 1 1 0 WhiA C-terminal HTH domain SVA PF05326.11 PIK51931.1 - 0.045 13.7 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) Nup54 PF13874.6 PIK51931.1 - 0.11 12.6 0.8 0.26 11.4 0.8 1.8 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 HSCB_C PF07743.13 PIK51931.1 - 0.13 12.8 2.3 0.16 12.5 0.4 2.0 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Phage_int_SAM_6 PF18644.1 PIK51931.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain ZapB PF06005.12 PIK51931.1 - 4.8 7.7 8.2 45 4.6 2.9 2.9 1 1 1 2 2 2 0 Cell division protein ZapB Ras PF00071.22 PIK51932.1 - 1.1e-38 132.4 1.4 9.9e-37 126.0 1.4 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK51932.1 - 5.2e-24 84.8 1.6 5.2e-23 81.5 0.9 2.5 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK51932.1 - 2.7e-06 27.0 0.5 0.00055 19.4 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK51932.1 - 1.1e-05 25.5 0.1 2.9e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK51932.1 - 0.00013 21.9 0.6 0.077 12.9 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 PIK51932.1 - 0.00096 18.6 0.2 0.0021 17.4 0.0 1.7 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 PIK51932.1 - 0.0036 16.8 0.1 1.4 8.5 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B ATP_bind_1 PF03029.17 PIK51932.1 - 0.01 15.6 2.6 3.7 7.3 0.1 2.9 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein DLIC PF05783.11 PIK51932.1 - 0.048 12.5 2.7 2.6 6.8 0.4 2.3 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) MMR_HSR1_Xtn PF16897.5 PIK51932.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain PGP_phosphatase PF09419.10 PIK51932.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Spt5_N PF11942.8 PIK51932.1 - 0.23 12.5 0.8 1.2 10.2 0.5 2.2 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal bPH_1 PF08000.11 PIK51933.1 - 0.0015 18.6 0.0 1.9 8.6 0.0 3.4 1 1 2 3 3 3 3 Bacterial PH domain zf-RING_UBOX PF13445.6 PIK51934.1 - 4.7e-09 36.1 10.1 1.2e-08 34.9 10.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK51934.1 - 7.7e-09 35.3 14.9 1.6e-08 34.3 14.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK51934.1 - 4.7e-08 33.2 12.0 1.3e-07 31.9 12.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK51934.1 - 1.5e-07 31.5 13.8 1.5e-07 31.5 13.8 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK51934.1 - 2.3e-07 30.6 13.5 5.1e-07 29.5 13.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK51934.1 - 2.6e-07 30.4 13.7 6.5e-07 29.1 13.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK51934.1 - 9.3e-06 25.5 12.8 1.9e-05 24.5 12.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK51934.1 - 0.018 14.9 14.0 0.018 14.9 14.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK51934.1 - 0.093 13.0 9.9 0.86 9.9 9.9 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain Perilipin PF03036.16 PIK51934.1 - 0.17 10.9 0.0 0.24 10.4 0.0 1.1 1 0 0 1 1 1 0 Perilipin family zf-RING_11 PF17123.5 PIK51934.1 - 0.18 11.6 11.8 0.64 9.8 11.8 2.0 1 0 0 1 1 1 0 RING-like zinc finger PBP1_TM PF14812.6 PIK51935.1 - 0.39 11.1 3.3 0.48 10.8 3.3 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RVT_1 PF00078.27 PIK51936.1 - 5.1e-12 45.8 0.0 6.7e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK51937.1 - 7.8e-07 28.8 1.7 3.1e-06 26.9 0.0 2.2 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 PIK51937.1 - 0.047 13.4 0.8 0.078 12.6 0.8 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type RT_RNaseH_2 PF17919.1 PIK51938.1 - 3.2e-33 113.7 0.0 1e-32 112.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK51938.1 - 1.5e-26 92.7 0.0 3.2e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK51938.1 - 3.8e-23 82.2 0.0 1.3e-22 80.4 0.0 1.9 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK51938.1 - 8.4e-17 61.0 0.6 1.8e-16 60.0 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK51938.1 - 1.2e-05 25.5 0.0 3.1e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK51938.1 - 0.066 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 H2C2 zinc finger Mut7-C PF01927.16 PIK51938.1 - 0.3 11.2 1.7 16 5.6 0.2 2.6 1 1 1 2 2 2 0 Mut7-C RNAse domain V-set PF07686.17 PIK51939.1 - 0.00015 21.9 0.1 0.00025 21.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK51939.1 - 0.074 13.7 0.1 0.074 13.7 0.1 2.4 3 1 0 3 3 3 0 Immunoglobulin domain MFS_1 PF07690.16 PIK51940.1 - 1.8e-20 73.1 13.4 1.9e-18 66.5 10.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily PID PF00640.23 PIK51941.1 - 6.7e-15 55.4 0.0 1.2e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.26 PIK51941.1 - 5.8e-05 23.1 6.5 5.8e-05 23.1 6.5 2.3 2 0 0 2 2 2 1 WW domain SDA1 PF05285.12 PIK51941.1 - 0.02 14.4 19.0 0.038 13.4 19.0 1.5 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.13 PIK51941.1 - 0.17 10.9 15.3 0.28 10.1 15.3 1.3 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 PIK51941.1 - 0.66 8.1 19.2 0.95 7.6 19.2 1.2 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 PIK51941.1 - 1.4 7.0 20.9 1.9 6.5 20.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 PIK51941.1 - 9.4 4.6 11.6 13 4.2 11.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PID PF00640.23 PIK51942.1 - 1e-11 45.1 0.1 1.2e-11 44.8 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Methyltr_RsmB-F PF01189.17 PIK51943.1 - 0.0018 17.9 0.1 0.0083 15.8 0.1 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 PIK51943.1 - 0.052 14.3 0.0 0.24 12.1 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain NAD_binding_2 PF03446.15 PIK51944.1 - 1.1e-40 139.3 1.9 1.9e-40 138.6 1.9 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 PIK51944.1 - 2.7e-25 89.0 0.4 9e-25 87.3 0.1 2.0 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.17 PIK51944.1 - 2e-18 66.6 1.4 7.7e-18 64.7 1.4 2.1 1 0 0 1 1 1 1 PWWP domain F420_oxidored PF03807.17 PIK51944.1 - 1.8e-06 28.4 0.4 6.4e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 PIK51944.1 - 2.8e-06 27.4 0.0 6.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 PIK51944.1 - 0.00017 21.0 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 PIK51944.1 - 0.00035 20.6 0.1 0.026 14.5 0.0 2.2 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 PIK51944.1 - 0.00046 20.1 0.5 0.0009 19.2 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 PIK51944.1 - 0.00092 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 PIK51944.1 - 0.035 14.5 0.0 0.094 13.2 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 PIK51944.1 - 0.068 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Use1 PF09753.9 PIK51944.1 - 0.072 12.8 6.7 0.11 12.1 6.7 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 IlvN PF07991.12 PIK51944.1 - 0.08 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AA_permease_2 PF13520.6 PIK51945.1 - 2.5e-50 171.6 40.6 2.4e-47 161.8 27.7 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 PIK51945.1 - 5.3e-14 51.7 28.9 5.3e-14 51.7 28.9 2.2 1 1 1 2 2 2 1 Amino acid permease PIH1_CS PF18201.1 PIK51946.1 - 1.2e-13 51.3 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 PIH1 CS-like domain HSP20 PF00011.21 PIK51946.1 - 0.012 15.7 0.2 0.085 13.0 0.0 2.4 2 1 1 3 3 3 0 Hsp20/alpha crystallin family THEG PF14912.6 PIK51947.1 - 2.4e-13 50.3 1.1 6.5e-09 36.1 0.1 2.1 1 1 1 2 2 2 2 Testicular haploid expressed repeat PDZ_2 PF13180.6 PIK51948.1 - 2.6e-08 34.0 0.0 7.2e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK51948.1 - 7.5e-08 32.1 0.1 1.7e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain C2 PF00168.30 PIK51948.1 - 4.6e-07 30.1 0.0 0.0008 19.7 0.0 2.8 2 0 0 2 2 2 2 C2 domain C1_1 PF00130.22 PIK51948.1 - 6.2e-07 29.2 12.2 1.3e-06 28.2 12.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ PF00595.24 PIK51948.1 - 6.6e-07 29.6 1.6 7.2e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 PDZ domain C1_2 PF03107.16 PIK51948.1 - 0.012 15.9 6.4 0.029 14.7 6.4 1.7 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 PIK51948.1 - 1.1 9.2 9.8 2.5 8.1 9.8 1.6 1 0 0 1 1 1 0 PHD-finger RhoGAP PF00620.27 PIK51949.1 - 8.8e-42 142.5 0.0 1.6e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Cullin_binding PF03556.15 PIK51951.1 - 6.3e-31 107.3 0.9 1.2e-30 106.4 0.9 1.5 1 0 0 1 1 1 1 Cullin binding Aa_trans PF01490.18 PIK51953.1 - 1.7e-74 251.0 30.8 2e-74 250.8 30.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LST1 PF05083.13 PIK51953.1 - 0.57 10.5 0.1 0.57 10.5 0.1 1.7 2 0 0 2 2 2 0 LST-1 protein tRNA-synt_1d PF00750.19 PIK51954.1 - 3.4e-109 365.0 0.1 6e-98 328.0 0.0 2.3 1 1 1 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.15 PIK51954.1 - 2.1e-30 105.4 0.0 6.2e-30 103.8 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 PIK51954.1 - 1.3e-11 45.0 0.3 3.6e-11 43.5 0.2 1.9 1 1 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Lebercilin PF15619.6 PIK51954.1 - 0.016 14.8 3.0 0.036 13.7 3.0 1.5 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Nup54 PF13874.6 PIK51954.1 - 0.06 13.4 0.5 0.14 12.3 0.5 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 HAP1_N PF04849.13 PIK51954.1 - 0.062 12.5 2.3 0.13 11.5 2.3 1.4 1 0 0 1 1 1 0 HAP1 N-terminal conserved region FapA PF03961.13 PIK51954.1 - 0.18 10.4 2.3 0.28 9.8 2.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A 60KD_IMP PF02096.20 PIK51954.1 - 0.2 11.6 0.5 0.44 10.4 0.5 1.7 1 0 0 1 1 1 0 60Kd inner membrane protein bZIP_2 PF07716.15 PIK51954.1 - 0.26 11.4 4.8 15 5.8 1.8 2.7 2 0 0 2 2 2 0 Basic region leucine zipper FlaC_arch PF05377.11 PIK51954.1 - 0.27 11.6 4.6 1.2 9.6 1.2 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 PIK51954.1 - 0.45 9.3 4.4 0.28 10.0 2.4 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DivIC PF04977.15 PIK51954.1 - 0.5 10.2 7.3 6.2 6.7 0.4 2.6 1 1 1 2 2 2 0 Septum formation initiator XhlA PF10779.9 PIK51954.1 - 3.6 7.9 5.2 1.1 9.5 0.6 2.3 2 0 0 2 2 2 0 Haemolysin XhlA EGF PF00008.27 PIK51956.1 - 1.1e-12 48.0 18.1 4.9e-07 29.9 5.8 2.5 2 1 0 2 2 2 2 EGF-like domain Laminin_G_2 PF02210.24 PIK51956.1 - 6.2e-09 36.5 0.1 8.4e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK51956.1 - 2.3e-07 31.1 0.1 3.3e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 PIK51956.1 - 6.4e-07 29.8 20.9 6e-06 26.7 3.6 3.0 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_CA PF07645.15 PIK51956.1 - 0.0019 18.4 24.3 0.004 17.3 9.5 2.3 1 1 1 2 2 2 1 Calcium-binding EGF domain EGF_3 PF12947.7 PIK51956.1 - 0.0094 16.1 12.0 0.052 13.7 3.4 2.6 1 1 1 2 2 2 2 EGF domain EGF_2 PF07974.13 PIK51956.1 - 0.016 15.6 9.5 0.016 15.6 9.5 2.3 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 PIK51956.1 - 0.17 12.0 16.6 4.9 7.4 8.2 2.4 1 1 1 2 2 2 0 Laminin EGF domain Cadherin PF00028.17 PIK51957.1 - 1.3e-119 391.0 14.3 1.3e-19 70.4 0.1 9.1 9 0 0 9 9 9 8 Cadherin domain Cadherin_2 PF08266.12 PIK51957.1 - 4.3e-13 48.9 0.2 0.42 10.5 0.0 8.0 8 1 0 8 8 8 5 Cadherin-like Cadherin_4 PF17803.1 PIK51957.1 - 2.3e-10 40.9 31.7 0.029 15.0 1.5 7.4 7 0 0 7 7 7 6 Bacterial cadherin-like domain Cadherin_3 PF16184.5 PIK51957.1 - 2.3e-05 24.4 10.9 1.5 8.9 0.1 6.8 7 0 0 7 7 7 3 Cadherin-like Big_9 PF17963.1 PIK51957.1 - 3.8e-05 24.3 40.2 0.12 13.1 3.5 8.0 8 1 1 9 9 9 3 Bacterial Ig domain SusE PF14292.6 PIK51957.1 - 0.22 11.7 3.3 1.6 9.0 0.2 3.8 4 0 0 4 4 4 0 SusE outer membrane protein Cadherin PF00028.17 PIK51958.1 - 3.8e-63 210.0 7.9 2.4e-21 76.0 0.4 4.1 4 0 0 4 4 4 4 Cadherin domain Cadherin_2 PF08266.12 PIK51958.1 - 1.1e-08 34.7 0.1 1.9 8.4 0.0 4.4 4 0 0 4 4 4 4 Cadherin-like Cadherin_pro PF08758.11 PIK51958.1 - 0.00081 19.5 0.0 0.031 14.4 0.0 2.7 2 0 0 2 2 2 1 Cadherin prodomain like P2_Phage_GpR PF06891.11 PIK51958.1 - 0.017 15.2 0.2 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 P2 phage tail completion protein R (GpR) Cadherin PF00028.17 PIK51959.1 - 3.2e-41 139.7 0.1 5.1e-22 78.1 0.0 2.1 2 0 0 2 2 2 2 Cadherin domain Cadherin_2 PF08266.12 PIK51959.1 - 0.00034 20.4 0.0 0.17 11.7 0.0 2.3 2 0 0 2 2 2 2 Cadherin-like RET_CLD1 PF17756.1 PIK51959.1 - 0.0019 18.5 0.0 0.098 12.9 0.0 2.3 2 0 0 2 2 2 1 RET Cadherin like domain 1 Cadherin-like PF12733.7 PIK51959.1 - 0.0033 17.9 6.5 0.41 11.2 0.7 2.3 2 0 0 2 2 2 2 Cadherin-like beta sandwich domain SusE PF14292.6 PIK51959.1 - 0.028 14.6 0.5 4.7 7.5 0.1 2.4 2 1 0 2 2 2 0 SusE outer membrane protein Cadherin_3 PF16184.5 PIK51959.1 - 0.048 13.7 0.6 0.34 10.9 0.1 2.2 2 1 0 2 2 2 0 Cadherin-like Cadherin PF00028.17 PIK51960.1 - 2.2e-63 210.7 4.5 1.9e-19 69.9 0.2 4.1 4 0 0 4 4 4 4 Cadherin domain Cadherin_3 PF16184.5 PIK51960.1 - 3.3e-12 46.4 5.6 1.9e-05 24.6 0.1 4.2 4 0 0 4 4 4 3 Cadherin-like Cadherin_4 PF17803.1 PIK51960.1 - 2.2e-08 34.6 27.0 0.0059 17.2 2.6 3.9 4 0 0 4 4 4 3 Bacterial cadherin-like domain Cadherin_2 PF08266.12 PIK51960.1 - 0.003 17.3 0.0 10 6.0 0.0 4.3 4 1 0 4 4 4 1 Cadherin-like Cadherin PF00028.17 PIK51961.1 - 8.1e-56 186.5 2.5 7.2e-15 55.2 0.0 4.1 4 0 0 4 4 4 4 Cadherin domain RET_CLD1 PF17756.1 PIK51961.1 - 1.7e-11 44.5 0.0 0.00018 21.8 0.0 3.7 4 0 0 4 4 4 3 RET Cadherin like domain 1 Cadherin_2 PF08266.12 PIK51961.1 - 3.3e-07 30.0 0.0 1.3 8.9 0.0 4.4 4 0 0 4 4 4 3 Cadherin-like Cadherin_4 PF17803.1 PIK51961.1 - 0.0025 18.4 3.2 0.0025 18.4 3.2 3.5 4 0 0 4 4 4 1 Bacterial cadherin-like domain Cadherin_3 PF16184.5 PIK51961.1 - 0.0066 16.4 1.0 0.045 13.7 0.1 2.7 2 1 1 3 3 3 1 Cadherin-like Cadherin PF00028.17 PIK51962.1 - 2e-191 621.1 42.5 3.6e-24 85.0 0.1 12.4 12 1 0 12 12 12 12 Cadherin domain Cadherin_2 PF08266.12 PIK51962.1 - 2.5e-13 49.6 0.0 0.13 12.1 0.0 8.3 9 0 0 9 9 9 3 Cadherin-like Cadherin_pro PF08758.11 PIK51962.1 - 6.8e-07 29.4 0.0 0.012 15.8 0.0 5.3 5 0 0 5 5 5 1 Cadherin prodomain like RET_CLD1 PF17756.1 PIK51962.1 - 0.06 13.6 0.1 37 4.6 0.0 4.3 6 0 0 6 6 6 0 RET Cadherin like domain 1 CD36 PF01130.21 PIK51963.1 - 4.8e-143 477.1 0.5 6e-143 476.8 0.5 1.0 1 0 0 1 1 1 1 CD36 family DUF202 PF02656.15 PIK51963.1 - 0.0099 16.3 3.8 0.054 13.9 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Neurensin PF14927.6 PIK51963.1 - 0.056 13.1 1.5 7.9 6.2 1.2 2.3 2 0 0 2 2 2 0 Neurensin DUF3096 PF11295.8 PIK51963.1 - 3.5 7.3 12.2 1.5 8.6 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3096) CD36 PF01130.21 PIK51964.1 - 3.5e-122 408.3 1.1 4.1e-122 408.1 1.1 1.0 1 0 0 1 1 1 1 CD36 family NACHT PF05729.12 PIK51965.1 - 3.9e-10 39.9 0.0 1e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK51965.1 - 0.00034 20.2 0.0 0.0035 16.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 PIK51965.1 - 0.014 15.8 0.0 0.046 14.2 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SHS2_FTSA PF02491.20 PIK51965.1 - 0.39 11.1 3.7 3 8.3 0.0 3.7 4 0 0 4 4 4 0 SHS2 domain inserted in FTSA LRR_6 PF13516.6 PIK51966.1 - 3.6 7.9 4.6 34 4.8 0.1 3.5 4 0 0 4 4 4 0 Leucine Rich repeat THAP PF05485.12 PIK51967.1 - 0.0028 18.6 0.1 0.015 16.2 0.0 2.3 2 0 0 2 2 2 1 THAP domain Chlam_OMP3 PF03503.13 PIK51967.1 - 0.28 11.5 2.3 2 8.8 0.1 2.6 2 0 0 2 2 2 0 Chlamydia cysteine-rich outer membrane protein 3 zf-C3HC4 PF00097.25 PIK51968.1 - 2e-10 40.4 8.0 2e-10 40.4 8.0 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK51968.1 - 3.8e-10 39.6 8.7 3.8e-10 39.6 8.7 2.9 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK51968.1 - 1.4e-08 34.4 9.7 1.4e-08 34.4 9.7 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK51968.1 - 2.1e-07 31.1 8.0 2.1e-07 31.1 8.0 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK51968.1 - 2.9e-07 30.6 9.9 2.9e-07 30.6 9.9 4.0 3 2 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK51968.1 - 3.8e-06 26.7 8.8 3.8e-06 26.7 8.8 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK51968.1 - 1.1e-05 25.5 29.6 0.00011 22.3 14.0 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 PIK51968.1 - 7.6e-05 22.6 7.1 7.6e-05 22.6 7.1 3.6 3 0 0 3 3 3 1 zinc-RING finger domain UL45 PF05473.12 PIK51969.1 - 7.8e-05 22.4 0.0 8.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK51969.1 - 0.0005 20.8 0.0 0.00089 20.0 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain GAS2 PF02187.17 PIK51970.1 - 1.4e-20 73.1 0.5 2e-20 72.7 0.5 1.2 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Cpn60_TCP1 PF00118.24 PIK51971.1 - 6.7e-148 493.4 15.7 7.7e-148 493.2 15.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 PIK51971.1 - 0.067 13.1 4.4 0.27 11.1 0.7 2.8 2 2 0 2 2 2 0 DAK2 domain Pkinase PF00069.25 PIK51972.1 - 6.8e-45 153.5 0.0 1.1e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK51972.1 - 2e-19 69.9 0.0 3.9e-19 69.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK51972.1 - 0.04 13.3 0.1 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SHIPPO-rpt PF07004.12 PIK51973.1 - 3.4e-17 62.5 33.7 2.4e-06 28.2 2.2 6.6 6 1 0 6 6 6 5 Sperm-tail PG-rich repeat Mif2_N PF15624.6 PIK51974.1 - 0.4 11.4 7.5 0.71 10.6 7.5 1.6 1 1 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal VWC PF00093.18 PIK51975.1 - 1.5e-17 63.7 41.3 2.9e-10 40.3 16.4 6.7 6 2 1 7 7 6 4 von Willebrand factor type C domain EGF_CA PF07645.15 PIK51975.1 - 1.4e-10 41.2 18.7 2.2e-10 40.5 6.7 8.1 7 2 0 7 7 3 2 Calcium-binding EGF domain Laminin_G_3 PF13385.6 PIK51975.1 - 1.1e-08 35.4 0.0 1.7e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 PIK51975.1 - 3.6e-05 24.3 0.0 7.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 PIK51975.1 - 0.00011 22.7 4.6 0.00011 22.7 4.6 9.4 11 0 0 11 11 6 2 Human growth factor-like EGF EGF PF00008.27 PIK51975.1 - 0.00016 21.9 3.5 0.00016 21.9 3.5 7.5 7 0 0 7 7 5 1 EGF-like domain TILa PF12714.7 PIK51975.1 - 0.00065 19.6 31.7 0.00091 19.1 11.8 8.7 5 2 3 9 9 9 3 TILa domain Laminin_G_1 PF00054.23 PIK51975.1 - 0.0019 18.4 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Pacifastin_I PF05375.13 PIK51975.1 - 0.014 15.1 7.7 0.014 15.1 7.7 6.4 6 0 0 6 6 5 0 Pacifastin inhibitor (LCMII) cEGF PF12662.7 PIK51975.1 - 0.017 15.0 1.8 0.017 15.0 1.8 6.0 6 0 0 6 6 4 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK51975.1 - 0.083 13.0 32.0 0.047 13.8 1.3 5.9 5 0 0 5 5 5 0 MSP1 EGF domain 1 BIR PF00653.21 PIK51976.1 - 0.24 12.1 1.2 1.5 9.5 1.2 2.1 1 1 0 1 1 1 0 Inhibitor of Apoptosis domain DUF836 PF05768.14 PIK51977.1 - 0.13 12.7 0.1 0.29 11.6 0.1 1.5 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) His_Phos_1 PF00300.22 PIK51981.1 - 1.4e-29 103.2 0.0 1.5e-26 93.3 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Peptidase_A17 PF05380.13 PIK51982.1 - 8.5e-58 194.9 0.0 1.8e-57 193.9 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK51982.1 - 8.7e-14 51.7 0.0 2e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) rve PF00665.26 PIK51982.1 - 1.8e-13 50.7 0.0 5.1e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK51982.1 - 1.3e-06 28.4 2.6 4.3e-06 26.7 2.6 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK51982.1 - 4.8e-06 26.3 0.0 9.7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK51982.1 - 0.00013 22.5 0.0 0.00035 21.1 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK51982.1 - 0.00032 21.3 0.0 0.00084 19.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 PIK51982.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) rve_3 PF13683.6 PIK51982.1 - 0.02 14.7 0.0 0.075 12.8 0.0 2.0 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.10 PIK51982.1 - 0.09 13.0 3.5 0.22 11.7 3.5 1.7 1 0 0 1 1 1 0 H2C2 zinc finger rve PF00665.26 PIK51983.1 - 1.2e-11 44.8 0.0 2e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK51983.1 - 0.0012 18.5 0.0 0.0055 16.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DUF3110 PF11360.8 PIK51983.1 - 0.066 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) CarboxypepD_reg PF13620.6 PIK51985.1 - 0.00089 19.5 0.0 0.0014 18.9 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain 2OG-FeII_Oxy PF03171.20 PIK51986.1 - 2e-17 63.5 0.0 3e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2292 PF10055.9 PIK51986.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2292) DIOX_N PF14226.6 PIK51987.1 - 1.1e-17 64.8 0.0 1.4e-17 64.5 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal RWD PF05773.22 PIK51988.1 - 4.9e-07 30.0 1.0 6.6e-05 23.2 0.2 2.3 2 0 0 2 2 2 1 RWD domain zf-rbx1 PF12678.7 PIK51988.1 - 5.8e-05 23.3 3.4 5.8e-05 23.3 3.4 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK51988.1 - 0.00022 21.0 4.7 0.00027 20.7 2.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK51988.1 - 0.00024 21.4 3.5 0.0016 18.7 3.5 2.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 PIK51988.1 - 0.00049 20.0 2.8 0.00049 20.0 2.8 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK51988.1 - 0.0064 16.5 2.2 0.031 14.3 2.2 2.3 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK51988.1 - 0.0081 16.0 0.4 0.034 14.0 0.4 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 PIK51988.1 - 0.0087 15.9 3.4 0.063 13.2 3.4 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK51988.1 - 0.036 13.9 4.1 0.1 12.5 1.4 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF440 PF04269.12 PIK51988.1 - 0.079 13.3 0.0 7.7 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF440 zf-ANAPC11 PF12861.7 PIK51988.1 - 0.08 13.0 0.8 0.16 12.0 0.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger His_kinase PF06580.13 PIK51988.1 - 0.1 12.9 0.1 5.2 7.5 0.1 2.4 2 0 0 2 2 2 0 Histidine kinase zf-RING-like PF08746.11 PIK51988.1 - 0.62 10.4 4.1 0.56 10.6 0.3 2.7 2 0 0 2 2 2 0 RING-like domain zf-RING_4 PF14570.6 PIK51988.1 - 1.8 8.4 4.8 0.34 10.7 0.5 2.0 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 PIK51988.1 - 2.4 8.0 6.1 0.66 9.8 1.3 2.7 3 0 0 3 3 3 0 RING-like zinc finger Tub PF01167.18 PIK51989.1 - 4.7e-53 180.4 0.1 7.1e-53 179.8 0.1 1.2 1 0 0 1 1 1 1 Tub family PIH1 PF08190.12 PIK51990.1 - 2.7e-14 53.0 0.0 2.9e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 PIH1 N-terminal domain BEN PF10523.9 PIK51991.1 - 0.00067 19.8 0.1 0.0019 18.4 0.1 1.7 1 0 0 1 1 1 1 BEN domain UPF0242 PF06785.11 PIK51991.1 - 0.058 13.5 0.7 0.12 12.5 0.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Raptor_N PF14538.6 PIK51991.1 - 0.089 12.7 1.0 1.4 8.8 0.1 2.7 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain FUR PF01475.19 PIK51992.1 - 0.03 14.5 0.3 0.082 13.1 0.3 1.6 2 0 0 2 2 2 0 Ferric uptake regulator family HTH_32 PF13565.6 PIK51992.1 - 0.031 14.9 0.2 0.27 11.9 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain TBPIP PF07106.13 PIK51992.1 - 0.05 13.6 0.1 3.4 7.7 0.1 2.7 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain B5 PF03484.15 PIK51992.1 - 0.091 13.1 0.0 0.79 10.1 0.0 2.3 1 1 0 1 1 1 0 tRNA synthetase B5 domain DUF4805 PF16063.5 PIK51992.1 - 0.11 11.8 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) LRR_6 PF13516.6 PIK51993.1 - 1e-12 47.0 4.1 0.019 15.0 0.1 6.4 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 PIK51993.1 - 2.5e-06 27.7 6.0 1.1 9.8 0.1 4.7 3 1 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK51993.1 - 0.00047 20.3 4.8 22 6.1 0.0 6.2 6 1 1 7 7 7 1 Leucine Rich Repeat SAM_Ste50p PF09235.10 PIK51993.1 - 0.41 10.9 3.9 23 5.3 0.1 3.6 4 1 1 5 5 5 0 Ste50p, sterile alpha motif Y_phosphatase PF00102.27 PIK51994.1 - 2.6e-85 285.7 2.1 3.1e-85 285.5 2.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK51994.1 - 0.00014 22.0 0.0 0.00051 20.2 0.0 1.9 1 1 1 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.20 PIK51994.1 - 0.00061 19.6 0.1 0.001 18.9 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK51994.1 - 0.00069 19.7 0.0 0.00092 19.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family NACHT PF05729.12 PIK51995.1 - 1.7e-05 24.8 0.0 0.00062 19.7 0.0 2.3 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK51995.1 - 0.025 14.1 0.0 0.074 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sigma54_AID PF00309.20 PIK51995.1 - 0.04 13.8 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) RT_RNaseH PF17917.1 PIK51997.1 - 5.1e-29 100.7 0.0 8.6e-29 99.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK51997.1 - 7.4e-27 93.3 0.1 1.5e-26 92.4 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK51997.1 - 9.7e-16 57.6 0.1 1.9e-15 56.7 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK51997.1 - 8.2e-06 25.9 0.1 2.3e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 H2C2 zinc finger gag-asp_proteas PF13975.6 PIK51998.1 - 0.00094 19.7 1.0 0.0034 17.9 0.1 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK51998.1 - 0.0059 17.2 0.1 0.016 15.8 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease SIS PF01380.22 PIK51998.1 - 0.03 14.2 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 SIS domain ADD_DNMT3 PF17980.1 PIK51998.1 - 0.04 13.9 2.5 0.091 12.8 2.5 1.5 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 Asp_protease PF09668.10 PIK51998.1 - 0.079 12.8 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Mating_N PF12731.7 PIK51999.1 - 0.046 13.8 0.9 0.085 13.0 0.1 1.8 2 1 0 2 2 2 0 Mating-type protein beta 1 Phlebovirus_NSM PF07246.11 PIK51999.1 - 0.095 12.1 1.1 0.13 11.7 0.6 1.4 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M NACHT PF05729.12 PIK52000.1 - 6.6e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK52000.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK52000.1 - 0.16 12.2 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK52002.1 - 2.4e-11 43.8 0.0 5.8e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK52002.1 - 2.1e-05 24.2 0.0 0.0077 15.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 PIK52002.1 - 0.00027 21.2 0.0 0.0013 19.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK52002.1 - 0.024 15.0 0.0 0.59 10.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DUF2075 PF09848.9 PIK52002.1 - 0.075 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ZU5 PF00791.20 PIK52003.1 - 1e-19 70.7 0.1 1.6e-13 50.8 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain ERM PF00769.19 PIK52004.1 - 7e-07 29.3 128.4 2.6e-05 24.2 38.5 3.9 1 1 3 4 4 4 4 Ezrin/radixin/moesin family APG6_N PF17675.1 PIK52004.1 - 2e-05 25.1 77.0 0.00069 20.1 34.3 5.6 1 1 5 6 6 6 4 Apg6 coiled-coil region GAS PF13851.6 PIK52004.1 - 8.5e-05 22.0 109.4 0.0022 17.4 28.6 4.9 1 1 4 5 5 5 4 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK52004.1 - 0.92 8.3 106.5 0.025 13.4 27.6 4.0 1 1 3 4 4 4 0 Spc7 kinetochore protein PilA4 PF18682.1 PIK52004.1 - 6.9 7.1 28.9 29 5.1 0.1 8.6 1 1 8 9 9 9 0 Pilin A4 DUF1664 PF07889.12 PIK52004.1 - 7.2 6.7 57.8 2.3 8.3 7.8 5.8 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Zip PF02535.22 PIK52005.1 - 7.8e-66 222.6 4.1 7.8e-66 222.6 4.1 2.7 2 1 0 2 2 2 1 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK52005.1 - 0.00077 19.4 0.2 0.0016 18.4 0.2 1.5 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain CPP1-like PF11833.8 PIK52005.1 - 3.1 7.4 6.1 19 4.8 0.2 2.4 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like zf-RVT PF13966.6 PIK52006.1 - 0.086 13.6 6.3 0.8 10.5 6.3 2.2 1 1 0 1 1 1 0 zinc-binding in reverse transcriptase RHSP PF07999.11 PIK52006.1 - 0.13 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein RVT_1 PF00078.27 PIK52007.1 - 4.7e-30 104.7 0.9 1e-29 103.7 0.9 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CDPS PF16715.5 PIK52007.1 - 0.03 14.0 2.7 0.048 13.3 2.7 1.2 1 0 0 1 1 1 0 Cyclodipeptide synthase DUF4175 PF13779.6 PIK52007.1 - 0.043 11.7 0.3 0.067 11.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4441 PF14536.6 PIK52007.1 - 0.12 12.5 3.9 3.2 8.0 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) Ig_3 PF13927.6 PIK52008.1 - 0.00017 22.1 0.4 0.042 14.4 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK52008.1 - 0.0013 18.9 0.3 0.015 15.4 0.2 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK52008.1 - 0.0031 17.8 0.3 0.73 10.2 0.1 2.9 2 0 0 2 2 2 1 Immunoglobulin domain RCR PF12273.8 PIK52008.1 - 0.019 15.7 1.9 0.043 14.5 1.9 1.6 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Cortexin PF11057.8 PIK52008.1 - 0.074 12.9 0.9 0.17 11.7 0.9 1.5 1 0 0 1 1 1 0 Cortexin of kidney Ig_3 PF13927.6 PIK52009.1 - 0.00019 22.0 2.9 0.74 10.5 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain DUF3377 PF11857.8 PIK52009.1 - 0.00059 19.7 1.7 0.004 17.0 0.8 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) V-set PF07686.17 PIK52009.1 - 0.011 15.9 0.6 1.1 9.4 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin V-set domain DUF4381 PF14316.6 PIK52009.1 - 0.012 15.8 0.3 0.027 14.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2681 PF10883.8 PIK52009.1 - 0.027 14.9 1.5 0.069 13.6 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) ig PF00047.25 PIK52009.1 - 0.03 14.5 2.9 0.63 10.3 0.1 3.6 3 1 0 3 3 3 0 Immunoglobulin domain DUF2269 PF10027.9 PIK52009.1 - 0.031 14.3 0.1 0.058 13.5 0.1 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) TssO PF17561.2 PIK52009.1 - 0.04 14.0 0.1 3.8 7.6 0.1 2.4 2 0 0 2 2 2 0 Type VI secretion system, TssO EphA2_TM PF14575.6 PIK52009.1 - 0.053 14.4 0.2 0.11 13.3 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_2 PF13895.6 PIK52009.1 - 0.069 13.5 3.7 1.2 9.5 0.0 3.5 3 1 0 3 3 3 0 Immunoglobulin domain DUF3328 PF11807.8 PIK52009.1 - 0.082 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Ig_3 PF13927.6 PIK52010.1 - 6.9e-08 33.0 0.2 0.0066 17.0 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52010.1 - 3.1e-05 23.9 0.0 8.1e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK52010.1 - 8.6e-05 22.6 3.4 1.7 8.8 0.1 3.9 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK52010.1 - 0.0005 20.1 0.1 1.7 8.7 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK52010.1 - 0.00053 20.1 1.8 0.0097 16.1 0.3 3.0 2 2 1 3 3 3 1 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK52010.1 - 0.024 14.9 1.2 0.63 10.3 0.4 2.8 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain DUF2207 PF09972.9 PIK52010.1 - 0.1 11.3 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GRAB PF10375.9 PIK52012.1 - 0.02 14.7 1.2 2.7 8.0 0.2 2.6 2 0 0 2 2 2 0 GRIP-related Arf-binding domain Baseplate PF16774.5 PIK52012.1 - 0.13 12.1 0.0 14 5.6 0.0 2.2 2 0 0 2 2 2 0 Baseplate protein RT_RNaseH_2 PF17919.1 PIK52013.1 - 4.5e-35 119.7 1.3 6.9e-35 119.1 0.1 2.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52013.1 - 1.4e-32 112.1 0.0 3.8e-32 110.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52013.1 - 1.4e-18 67.3 0.1 3.5e-18 65.9 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK52013.1 - 9.8e-17 60.8 0.7 1.8e-16 60.0 0.7 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK52013.1 - 2.1e-07 31.0 0.5 4.5e-07 30.0 0.5 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Carn_acyltransf PF00755.20 PIK52014.1 - 2.6e-147 492.0 0.0 3e-147 491.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase EamA PF00892.20 PIK52015.1 - 1.9e-07 31.3 25.5 1.1e-05 25.6 12.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family UPAR_LY6_2 PF16975.5 PIK52016.1 - 0.36 11.0 14.9 0.66 10.2 14.9 1.5 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 C2-set_2 PF08205.12 PIK52018.1 - 9.6e-05 22.4 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF2207 PF09972.9 PIK52018.1 - 0.043 12.6 0.0 0.064 12.0 0.0 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) SurA_N_2 PF13623.6 PIK52018.1 - 0.18 11.7 0.4 0.48 10.3 0.4 1.8 1 1 0 1 1 1 0 SurA N-terminal domain Ig_3 PF13927.6 PIK52019.1 - 4.4e-12 46.4 0.2 6.1e-05 23.5 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK52019.1 - 6.3e-09 36.1 0.7 0.022 15.1 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK52019.1 - 2.3e-06 27.6 0.1 0.0029 17.6 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK52019.1 - 4.5e-06 26.6 0.2 4.6e-05 23.4 0.0 2.3 2 1 1 3 3 3 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK52019.1 - 6.1e-05 23.1 1.2 1.8 8.8 0.4 4.2 2 1 2 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK52019.1 - 0.0035 17.5 0.3 0.038 14.2 0.2 2.6 2 2 1 3 3 3 1 Immunoglobulin V-set domain Pkinase PF00069.25 PIK52021.1 - 2.1e-40 138.8 0.5 1.2e-34 119.9 0.8 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52021.1 - 8.9e-26 90.7 0.0 3e-23 82.4 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK52021.1 - 0.013 14.8 0.1 0.16 11.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 PIK52021.1 - 0.054 13.1 0.7 0.13 11.8 0.7 1.6 1 1 0 1 1 1 0 RIO1 family Ig_3 PF13927.6 PIK52022.1 - 3.8e-11 43.4 0.1 0.00091 19.8 0.0 3.3 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK52022.1 - 2.2e-07 31.0 0.2 0.23 11.6 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK52022.1 - 4.1e-06 26.8 0.0 0.15 12.2 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52022.1 - 7.4e-06 26.2 11.7 0.019 15.3 0.1 4.9 5 1 1 6 6 6 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52022.1 - 0.0002 21.4 0.0 0.00071 19.6 0.0 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK52022.1 - 0.00034 20.7 0.5 0.012 15.7 0.1 3.1 4 0 0 4 4 4 1 Immunoglobulin V-set domain Adeno_E3_CR1 PF02440.15 PIK52022.1 - 3.3 7.5 5.9 0.67 9.8 0.2 2.6 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Pkinase_Tyr PF07714.17 PIK52023.1 - 6.5e-15 55.1 0.0 8.5e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52023.1 - 0.023 14.1 0.0 0.041 13.2 0.0 1.4 1 1 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52024.1 - 3.7e-27 95.2 0.0 4.9e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52024.1 - 3.2e-07 30.0 0.0 4.6e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Nup160 PF11715.8 PIK52025.1 - 7e-55 186.7 0.0 1e-54 186.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_8 PF13181.6 PIK52025.1 - 0.0043 17.2 0.4 0.032 14.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK52025.1 - 0.0046 16.7 0.0 0.024 14.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK52025.1 - 0.0096 16.0 0.7 0.066 13.4 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK52025.1 - 0.031 14.3 0.1 0.37 10.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK52025.1 - 0.095 13.6 0.2 16 6.6 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MFAP1 PF06991.11 PIK52026.1 - 3.2e-74 249.4 29.2 3.2e-74 249.4 29.2 2.5 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing GSG-1 PF07803.11 PIK52026.1 - 0.07 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 GSG1-like protein Bromo_TP PF07524.13 PIK52027.1 - 5.5e-20 71.2 0.1 1e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 PIK52027.1 - 0.004 17.3 0.1 0.0073 16.5 0.1 1.6 1 1 0 1 1 1 1 Histone-fold protein TAF8_C PF10406.9 PIK52027.1 - 0.0056 17.2 0.1 0.017 15.7 0.1 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Syntaxin_2 PF14523.6 PIK52027.1 - 0.041 14.2 1.7 0.075 13.4 0.2 2.1 2 0 0 2 2 2 0 Syntaxin-like protein CENP-S PF15630.6 PIK52027.1 - 0.097 13.1 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 CENP-S protein SBBP PF06739.11 PIK52028.1 - 0.00016 21.6 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Beta-propeller repeat SCAB_CC PF16712.5 PIK52028.1 - 0.016 15.1 0.3 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 Coiled-coil regions of plant-specific actin-binding protein NHL PF01436.21 PIK52028.1 - 0.24 11.5 0.7 14 5.9 0.1 3.7 4 0 0 4 4 4 0 NHL repeat RPW8 PF05659.11 PIK52028.1 - 1.5 8.5 8.0 2.4 7.8 1.7 3.4 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 SCNM1_acidic PF15805.5 PIK52029.1 - 5.9e-19 67.5 4.8 1.3e-18 66.4 4.8 1.6 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 zf-SCNM1 PF15803.5 PIK52029.1 - 1.4e-11 43.8 5.9 3e-11 42.7 5.9 1.6 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 DUF2387 PF09526.10 PIK52029.1 - 3 8.1 5.5 4.9 7.4 0.7 3.5 2 1 1 3 3 3 0 Probable metal-binding protein (DUF2387) zf-RING_4 PF14570.6 PIK52030.1 - 3.1e-20 71.7 12.1 6.5e-20 70.7 12.1 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 PIK52030.1 - 4.4e-07 29.6 0.0 9.1e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 PIK52030.1 - 3.4e-05 23.6 10.7 3.4e-05 23.6 10.7 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK52030.1 - 0.0096 16.2 10.5 0.0096 16.2 10.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK52030.1 - 0.011 15.6 9.9 0.011 15.6 9.9 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK52030.1 - 0.011 15.5 9.7 0.043 13.7 9.7 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nup35_RRM_2 PF14605.6 PIK52030.1 - 0.027 14.5 0.0 0.059 13.4 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Torus PF16131.5 PIK52030.1 - 0.032 14.9 0.2 0.093 13.4 0.2 1.8 1 0 0 1 1 1 0 Torus domain Baculo_IE-1 PF05290.11 PIK52030.1 - 0.056 13.4 5.4 0.023 14.6 2.2 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Nup35_RRM PF05172.13 PIK52030.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-UDP PF14569.6 PIK52030.1 - 0.093 12.9 6.0 0.26 11.4 6.0 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-H2C2_2 PF13465.6 PIK52030.1 - 0.55 10.8 4.4 4 8.0 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger double domain SSP160 PF06933.11 PIK52030.1 - 3.1 5.9 8.4 4.9 5.2 8.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FYVE_2 PF02318.16 PIK52030.1 - 4.9 7.4 8.4 0.76 10.0 3.3 2.1 2 0 0 2 2 2 0 FYVE-type zinc finger TFIIE_beta PF02186.15 PIK52031.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 TFIIE beta subunit core domain Adeno_PV PF03910.13 PIK52031.1 - 0.11 11.2 1.3 0.15 10.7 1.3 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Fic PF02661.18 PIK52032.1 - 3.9e-27 95.0 0.2 1.3e-26 93.3 0.0 2.0 2 1 0 2 2 2 1 Fic/DOC family TPR_2 PF07719.17 PIK52032.1 - 0.00073 19.5 0.4 0.0022 17.9 0.4 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK52032.1 - 0.0014 18.9 0.4 0.0065 16.8 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK52032.1 - 0.0035 17.1 0.1 0.012 15.4 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK52032.1 - 0.0036 17.9 0.0 0.0093 16.6 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK52032.1 - 0.045 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_10 PF13374.6 PIK52032.1 - 0.12 12.2 0.1 5.2 7.1 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Mannosyl_trans2 PF04188.13 PIK52033.1 - 8.9e-66 223.0 22.1 1.1e-65 222.7 22.1 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) TMEM132D_C PF15706.5 PIK52034.1 - 0.085 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term HTH_12 PF08461.10 PIK52036.1 - 0.023 14.6 1.4 0.023 14.6 1.4 2.3 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain Aminotran_1_2 PF00155.21 PIK52037.1 - 5.1e-50 170.7 0.0 6.2e-50 170.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 PIK52037.1 - 2e-05 24.1 0.0 3.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 PIK52037.1 - 0.00017 20.2 0.0 0.00028 19.5 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 PIK52037.1 - 0.00036 19.9 0.0 0.00053 19.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 PIK52037.1 - 0.0053 15.8 0.0 0.0077 15.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_3 PF00202.21 PIK52037.1 - 0.075 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III SCAN PF02023.17 PIK52038.1 - 1.2e-10 41.1 0.1 3.3e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 SCAN domain RT_RNaseH PF17917.1 PIK52039.1 - 9.9e-34 115.8 0.1 2.9e-33 114.3 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK52039.1 - 1.3e-31 108.5 0.0 3.4e-31 107.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52039.1 - 1.1e-28 100.3 0.0 2.1e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK52039.1 - 1.9e-20 72.7 1.3 1.9e-20 72.7 1.3 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK52039.1 - 2.9e-19 69.4 0.0 1e-17 64.4 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK52039.1 - 0.00043 20.4 1.3 0.0017 18.5 0.7 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK52039.1 - 0.031 14.0 0.2 0.17 11.7 0.0 2.3 2 1 1 3 3 3 0 Integrase core domain HSBP1 PF06825.12 PIK52039.1 - 0.43 10.5 2.5 4.5 7.2 0.0 2.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 MATH PF00917.26 PIK52040.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 MATH domain NAP PF00956.18 PIK52041.1 - 1.4e-33 116.2 8.7 1.7e-28 99.6 1.8 2.8 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.12 PIK52041.1 - 0.0015 18.4 1.7 0.0029 17.5 1.7 1.4 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF89 PF01937.19 PIK52041.1 - 0.039 12.9 0.1 0.28 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF89 DUF2948 PF11164.8 PIK52041.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) TMPIT PF07851.13 PIK52041.1 - 0.31 10.2 2.1 0.38 9.9 2.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Sigma70_ner PF04546.13 PIK52041.1 - 2.8 7.8 20.3 0.65 9.8 1.2 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region GFA PF04828.14 PIK52042.1 - 0.081 13.3 0.0 1.2 9.5 0.0 2.2 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme HOOK PF05622.12 PIK52043.1 - 0.067 11.3 30.1 0.052 11.7 28.3 1.6 2 0 0 2 2 2 0 HOOK protein DUF812 PF05667.11 PIK52043.1 - 0.26 10.1 27.3 0.43 9.4 27.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GAS PF13851.6 PIK52043.1 - 0.54 9.6 36.8 2.2 7.6 17.7 2.9 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding HrpB2 PF09487.10 PIK52043.1 - 0.81 10.1 5.9 0.17 12.3 0.4 2.4 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) Spc7 PF08317.11 PIK52044.1 - 0.0064 15.4 15.3 0.0064 15.4 15.3 5.7 1 1 4 5 5 5 2 Spc7 kinetochore protein Xan_ur_permease PF00860.20 PIK52045.1 - 3.6e-49 167.5 8.6 5.1e-49 167.0 8.6 1.1 1 0 0 1 1 1 1 Permease family FtsX PF02687.21 PIK52045.1 - 0.28 11.7 0.1 0.28 11.7 0.1 3.4 3 1 0 3 3 3 0 FtsX-like permease family Xan_ur_permease PF00860.20 PIK52046.1 - 7.2e-54 183.0 8.4 9.6e-54 182.6 8.4 1.1 1 0 0 1 1 1 1 Permease family FtsX PF02687.21 PIK52046.1 - 0.22 12.0 0.0 0.22 12.0 0.0 2.9 3 1 0 3 3 3 0 FtsX-like permease family ECH_1 PF00378.20 PIK52047.1 - 2.1e-34 118.9 0.1 5.2e-34 117.7 0.1 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK52047.1 - 5.7e-18 65.5 0.0 6.5e-18 65.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 PIK52047.1 - 0.0016 17.5 0.0 0.0024 16.9 0.0 1.3 1 0 0 1 1 1 1 Serine dehydrogenase proteinase FTA4 PF13093.6 PIK52047.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Peptidase_C34 PF05413.11 PIK52047.1 - 0.14 12.4 0.0 1.1 9.6 0.0 2.0 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase AAA_12 PF13087.6 PIK52048.1 - 1.5e-24 86.7 0.0 2.3e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 PIK52048.1 - 0.11 12.3 0.1 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 PIK52049.1 - 3.5e-16 59.8 0.0 5.4e-07 29.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 PIK52049.1 - 0.00012 21.7 0.0 0.00041 20.0 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 PIK52049.1 - 0.00059 19.6 0.1 0.002 17.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK52049.1 - 0.00073 19.9 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK52049.1 - 0.024 14.6 0.0 0.072 13.1 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 PIK52049.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Peptidase_A17 PF05380.13 PIK52051.1 - 7.2e-19 68.4 0.2 3.2e-18 66.3 0.0 2.2 2 0 0 2 2 2 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK52051.1 - 3.8e-07 30.1 1.0 7.6e-07 29.2 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) RVT_1 PF00078.27 PIK52051.1 - 5.3e-05 22.9 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NUDE_C PF04880.13 PIK52051.1 - 0.44 11.0 5.3 1.7 9.1 5.3 2.0 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Peptidase_A17 PF05380.13 PIK52052.1 - 3.3e-40 137.7 1.0 4.4e-40 137.3 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK52052.1 - 5.5e-06 26.4 0.8 1.5e-05 25.0 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Lectin_C PF00059.21 PIK52053.1 - 4.9e-14 53.0 0.1 6.2e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK52053.1 - 0.097 12.3 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like HTH_3 PF01381.22 PIK52053.1 - 0.15 12.1 0.2 0.25 11.4 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix DUF1160 PF06648.11 PIK52054.1 - 0.14 12.1 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) Ras PF00071.22 PIK52055.1 - 1.1e-42 145.5 0.7 1.2e-42 145.2 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK52055.1 - 7.8e-13 48.7 0.1 1.4e-12 47.8 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK52055.1 - 7.9e-06 25.4 0.1 9.4e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK52055.1 - 3.1e-05 23.6 0.3 5.7e-05 22.7 0.3 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 PIK52055.1 - 8.1e-05 22.5 0.1 0.0001 22.2 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 PIK52055.1 - 0.0031 17.4 0.1 0.0055 16.6 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 PIK52055.1 - 0.01 15.3 0.3 0.09 12.3 0.3 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B VPS13 PF16908.5 PIK52056.1 - 1.7e-72 244.1 3.0 2.1e-72 243.7 3.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Gemini_AL3 PF01407.17 PIK52056.1 - 0.092 12.6 0.9 0.27 11.1 0.0 2.1 3 0 0 3 3 3 0 Geminivirus AL3 protein DUF5629 PF18629.1 PIK52056.1 - 0.17 12.5 0.8 0.39 11.3 0.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5629) VPS13_mid_rpt PF16910.5 PIK52057.1 - 6.2e-34 117.4 0.0 9.8e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Repeating coiled region of VPS13 VPS13_mid_rpt PF16910.5 PIK52058.1 - 2e-16 60.2 1.4 8.3e-11 41.8 0.0 4.6 4 1 0 4 4 4 2 Repeating coiled region of VPS13 Cytomega_UL84 PF06284.11 PIK52058.1 - 0.018 13.5 2.6 1.1 7.6 1.9 2.6 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein Treacle PF03546.14 PIK52059.1 - 0.07 11.9 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle SHR-BD PF06650.12 PIK52060.1 - 4.6e-24 85.2 0.0 1.1e-22 80.7 0.0 2.4 2 0 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 PIK52061.1 - 1e-65 220.9 2.5 2.4e-63 213.1 0.1 3.1 3 0 0 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 PIK52061.1 - 0.00012 22.3 0.0 0.0027 18.0 0.0 2.8 2 1 0 2 2 2 1 Autophagy-related protein C terminal domain DHFR_1 PF00186.19 PIK52062.1 - 4e-39 133.9 0.0 5e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Peptidase_M24 PF00557.24 PIK52063.1 - 1.1e-21 77.5 0.0 1.5e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 PIK52063.1 - 2e-05 25.2 0.0 4.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 PIK52064.1 - 1.3e-14 55.0 0.0 2.2e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 PIK52064.1 - 0.023 14.4 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 Metallopeptidase family M24 SDA1 PF05285.12 PIK52064.1 - 0.077 12.4 13.6 0.1 12.0 13.6 1.2 1 0 0 1 1 1 0 SDA1 DUF2722 PF10846.8 PIK52064.1 - 3 6.7 7.1 4.4 6.1 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Peptidase_M24 PF00557.24 PIK52065.1 - 5.4e-11 42.6 0.0 8.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Sulfotransfer_2 PF03567.14 PIK52066.1 - 1.8e-19 70.6 0.6 3.1e-19 69.9 0.6 1.4 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK52066.1 - 0.045 13.2 1.6 0.051 13.0 0.1 1.9 2 0 0 2 2 2 0 Sulfotransferase domain Hid1 PF12722.7 PIK52066.1 - 0.073 11.2 0.5 0.1 10.7 0.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0220 PF05255.11 PIK52067.1 - 1.5e-38 132.0 4.5 1.8e-38 131.7 4.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF1129 PF06570.11 PIK52067.1 - 0.57 9.6 3.2 0.33 10.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) YoqO PF14037.6 PIK52067.1 - 2.2 8.8 7.2 1.3 9.6 1.2 2.2 1 1 1 2 2 2 0 YoqO-like protein Pkinase PF00069.25 PIK52068.1 - 3.8e-41 141.2 1.2 4.2e-40 137.8 0.1 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52068.1 - 1.7e-21 76.7 0.0 3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK52068.1 - 1.5e-06 27.4 0.5 2.6e-06 26.6 0.5 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK52068.1 - 0.00098 19.1 0.1 0.0075 16.2 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK52068.1 - 0.0023 17.3 0.0 0.0065 15.9 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK52068.1 - 0.0088 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.11 PIK52068.1 - 0.018 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.11 PIK52068.1 - 0.027 13.5 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 PIK52069.1 - 0.0082 15.5 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain UPF0240 PF06784.11 PIK52070.1 - 6.5e-41 140.3 0.2 8.1e-41 140.0 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) RecX PF02631.16 PIK52070.1 - 0.0082 16.6 1.0 0.015 15.8 0.1 1.8 2 0 0 2 2 2 1 RecX family DUF501 PF04417.12 PIK52070.1 - 0.18 11.6 0.3 0.29 10.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF501) PARP PF00644.20 PIK52071.1 - 9e-11 41.7 0.0 2.8e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain BRCT_2 PF16589.5 PIK52071.1 - 8.3e-08 32.5 0.0 1.9e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK52071.1 - 1.4e-07 31.8 0.1 5e-07 30.0 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PARP_reg PF02877.14 PIK52071.1 - 0.00074 19.6 0.6 0.002 18.2 0.1 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain PTCB-BRCT PF12738.7 PIK52071.1 - 0.001 19.0 0.0 0.0025 17.7 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain NADH_u_ox_C PF12853.7 PIK52071.1 - 0.15 12.1 0.1 0.93 9.5 0.0 2.2 2 0 0 2 2 2 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit VIT PF08487.10 PIK52072.1 - 1.8e-41 140.8 1.9 2.1e-41 140.6 0.2 2.1 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 PIK52072.1 - 1e-15 58.0 0.0 1.9e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 PIK52072.1 - 1.2e-14 53.9 0.0 2.7e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 PIK52072.1 - 1.2e-09 38.7 0.0 2.6e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK52072.1 - 5.3e-06 27.0 0.0 1.2e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain PGA2 PF07543.12 PIK52072.1 - 1.6 8.7 7.7 0.43 10.5 0.7 3.1 1 1 1 2 2 2 0 Protein trafficking PGA2 V-set PF07686.17 PIK52074.1 - 3.1e-12 46.6 0.0 2.8e-08 33.9 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52074.1 - 3.7e-08 33.8 0.6 1.6e-05 25.4 0.0 4.0 4 3 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK52074.1 - 6.9e-08 32.4 0.2 9.6e-07 28.8 0.0 3.1 4 1 0 4 4 4 1 Immunoglobulin I-set domain ig PF00047.25 PIK52074.1 - 2.8e-06 27.4 0.1 0.004 17.3 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain HpcH_HpaI PF03328.14 PIK52075.1 - 5.4e-49 166.3 0.3 6.7e-49 166.0 0.3 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 PIK52075.1 - 5.1e-13 48.9 0.1 7.7e-07 28.6 0.0 2.1 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Shisa PF13908.6 PIK52076.1 - 0.13 12.4 0.2 0.13 12.4 0.2 2.1 1 1 2 3 3 3 0 Wnt and FGF inhibitory regulator Neur_chan_memb PF02932.16 PIK52076.1 - 0.83 9.7 7.0 3 7.8 7.1 1.8 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BIR PF00653.21 PIK52077.1 - 2.9e-37 127.1 16.1 2.3e-22 79.4 4.6 3.3 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK52077.1 - 1.9e-06 27.9 6.1 0.001 19.1 0.2 2.5 2 0 0 2 2 2 2 C3HC zinc finger-like DUF562 PF04763.12 PIK52077.1 - 0.09 12.2 0.0 0.23 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF562) DUF1676 PF07898.13 PIK52078.1 - 2.6e-05 24.4 0.0 5.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1676) NOA36 PF06524.12 PIK52078.1 - 0.00044 19.7 20.1 0.00044 19.7 20.1 2.2 2 0 0 2 2 2 1 NOA36 protein Orf78 PF06024.12 PIK52078.1 - 0.0018 18.5 1.2 0.032 14.5 0.5 3.0 2 1 0 2 2 2 1 Orf78 (ac78) PPP4R2 PF09184.11 PIK52078.1 - 0.0041 16.8 7.8 0.0057 16.3 7.8 1.2 1 0 0 1 1 1 1 PPP4R2 DUF2457 PF10446.9 PIK52078.1 - 0.035 13.3 32.4 0.057 12.6 32.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFB6 PF17110.5 PIK52078.1 - 0.077 12.7 4.1 0.12 12.1 4.1 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FmiP_Thoc5 PF09766.9 PIK52078.1 - 0.13 11.5 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Nop14 PF04147.12 PIK52078.1 - 0.53 8.4 18.4 0.7 8.0 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 PIK52078.1 - 0.54 8.3 29.5 0.84 7.7 29.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi CNDH2_C PF16858.5 PIK52078.1 - 0.58 10.0 5.4 0.8 9.5 5.4 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term TRAP_alpha PF03896.16 PIK52078.1 - 1.1 8.4 10.1 3.9 6.6 10.5 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2722 PF10846.8 PIK52078.1 - 2.9 6.7 11.4 4.1 6.2 11.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TraL PF07178.11 PIK52078.1 - 3 8.4 9.6 1.4 9.4 5.4 2.4 3 0 0 3 3 3 0 TraL protein Mpp10 PF04006.12 PIK52078.1 - 4.3 5.7 16.0 5.8 5.2 16.0 1.1 1 0 0 1 1 1 0 Mpp10 protein TFIIA PF03153.13 PIK52078.1 - 5 7.0 20.3 6.8 6.6 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 7tm_1 PF00001.21 PIK52079.1 - 2.7e-10 40.0 0.1 3.4e-10 39.7 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK52079.1 - 0.022 14.5 0.0 0.025 14.3 0.0 1.1 1 0 0 1 1 1 0 Olfactory receptor SEA PF01390.20 PIK52080.1 - 0.0007 19.7 0.1 0.0015 18.6 0.1 1.5 1 0 0 1 1 1 1 SEA domain EGF_3 PF12947.7 PIK52080.1 - 0.013 15.6 3.7 0.027 14.7 3.7 1.5 1 0 0 1 1 1 0 EGF domain CorC_HlyC PF03471.17 PIK52080.1 - 0.081 12.9 0.1 16 5.6 0.0 2.5 2 0 0 2 2 2 0 Transporter associated domain WD40 PF00400.32 PIK52081.1 - 2e-15 56.9 22.0 2.6e-05 24.9 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 PIK52081.1 - 0.00014 21.8 0.1 0.00036 20.5 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 PIK52081.1 - 0.0075 15.0 9.3 0.1 11.2 0.3 3.3 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Rav1p_C PF12234.8 PIK52081.1 - 0.029 12.8 0.3 0.038 12.4 0.3 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal Peptidase_C39_2 PF13529.6 PIK52081.1 - 0.11 13.1 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Peptidase_C39 like family DUF2480 PF10652.9 PIK52081.1 - 0.23 11.3 0.7 1.8 8.4 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2480) NAD_binding_10 PF13460.6 PIK52082.1 - 1.2e-30 106.8 0.2 1.9e-29 102.9 0.2 2.0 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK52082.1 - 2e-08 34.1 0.0 3.9e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK52082.1 - 1.7e-06 27.7 0.1 2.7e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 PIK52082.1 - 3.2e-05 24.2 0.3 7.6e-05 23.0 0.2 1.6 2 0 0 2 2 2 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 PIK52082.1 - 6.9e-05 22.4 0.0 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 PIK52082.1 - 0.0003 20.9 0.1 0.00055 20.1 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 PIK52082.1 - 0.0032 16.6 0.1 0.0047 16.1 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 PIK52082.1 - 0.036 13.1 0.0 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DFP PF04127.15 PIK52082.1 - 0.037 13.9 0.1 0.059 13.2 0.1 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_4 PF07993.12 PIK52082.1 - 0.047 12.8 0.0 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein adh_short PF00106.25 PIK52082.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Semialdhyde_dh PF01118.24 PIK52082.1 - 0.14 12.6 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DNA_gyraseA_C PF03989.13 PIK52082.1 - 0.19 11.3 0.0 0.36 10.3 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller RVT_1 PF00078.27 PIK52083.1 - 2e-12 47.1 0.2 3.4e-12 46.4 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spy1 PF11357.8 PIK52083.1 - 0.07 13.4 0.0 0.2 12.0 0.0 1.8 1 1 0 1 1 1 0 Cell cycle regulatory protein NAGidase PF07555.13 PIK52083.1 - 0.084 12.2 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase DUF3340 PF11818.8 PIK52084.1 - 0.57 10.3 0.0 0.57 10.3 0.0 3.2 3 0 0 3 3 3 0 C-terminal domain of tail specific protease (DUF3340) SAP PF02037.27 PIK52084.1 - 0.62 9.9 5.7 6.3 6.7 0.4 2.6 1 1 1 3 3 3 0 SAP domain UL42 PF17638.2 PIK52085.1 - 0.086 12.8 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 HCMV UL42 Shisa PF13908.6 PIK52086.1 - 0.015 15.5 1.8 0.015 15.5 1.8 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF4244 PF14029.6 PIK52086.1 - 0.12 11.9 0.6 0.2 11.1 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Mid2 PF04478.12 PIK52086.1 - 1.3 8.8 8.7 3.1 7.6 5.0 2.4 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor Mucin PF01456.17 PIK52086.1 - 1.7 8.6 21.0 1.4 8.9 0.1 2.3 1 1 1 2 2 2 0 Mucin-like glycoprotein Stevor PF17410.2 PIK52086.1 - 1.8 8.1 4.5 0.5 9.9 1.6 1.5 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 PIK52086.1 - 3.6 7.5 11.4 13 5.7 10.9 2.0 1 1 0 1 1 1 0 TMEM154 protein family eIF2_C PF09173.11 PIK52088.1 - 7.2e-31 106.3 0.4 1.7e-30 105.1 0.4 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 PIK52088.1 - 8.1e-18 64.7 0.0 1.4e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK52088.1 - 0.0016 18.4 0.1 0.0025 17.7 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 PIK52088.1 - 0.0097 15.9 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SRCR PF00530.18 PIK52089.1 - 2.1e-58 195.0 7.1 1.9e-27 95.7 1.1 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK52089.1 - 1.2e-10 41.8 2.7 0.00014 22.4 0.1 3.6 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK52089.1 - 8.9e-09 35.8 0.4 0.014 15.9 0.1 3.7 3 1 0 3 3 3 3 Hepsin, SRCR domain YecR PF13992.6 PIK52089.1 - 0.059 13.7 2.4 8.3 6.8 0.1 3.7 4 0 0 4 4 4 0 YecR-like lipoprotein SRCR PF00530.18 PIK52090.1 - 6.8e-25 87.5 0.4 8.6e-25 87.2 0.4 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK52090.1 - 1e-06 29.2 0.8 1.5e-06 28.6 0.8 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK52090.1 - 0.02 15.4 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 Hepsin, SRCR domain CoxIIa PF08113.11 PIK52090.1 - 0.12 12.3 3.3 0.2 11.5 3.3 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family FixQ PF05545.11 PIK52090.1 - 0.13 12.3 0.4 0.22 11.5 0.4 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ PMP22_Claudin PF00822.20 PIK52090.1 - 0.22 11.4 0.1 0.22 11.4 0.1 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family SRCR PF00530.18 PIK52091.1 - 2.9e-20 72.6 4.7 8.8e-11 42.2 0.1 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK52091.1 - 0.027 15.0 0.2 0.096 13.2 0.0 1.9 2 0 0 2 2 2 0 Scavenger receptor cysteine-rich domain Arch_flagellin PF01917.16 PIK52091.1 - 0.071 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Archaebacterial flagellin SRCR PF00530.18 PIK52092.1 - 8.3e-61 202.7 9.0 4e-31 107.5 0.4 3.2 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK52092.1 - 3.5e-13 49.9 5.4 1.1e-05 25.9 0.1 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK52092.1 - 1.1e-06 29.2 0.1 0.023 15.2 0.0 2.7 3 0 0 3 3 3 2 Hepsin, SRCR domain YecR PF13992.6 PIK52092.1 - 0.023 15.0 1.2 6.3 7.2 0.1 2.7 2 0 0 2 2 2 0 YecR-like lipoprotein DUF4062 PF13271.6 PIK52093.1 - 1.2e-10 41.6 0.0 4.1e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) NACHT PF05729.12 PIK52093.1 - 3.4e-06 27.1 0.0 7.6e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK52093.1 - 1.4e-05 25.4 0.1 0.00015 22.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 PIK52093.1 - 0.00017 21.6 0.1 0.00036 20.5 0.1 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 PIK52093.1 - 0.004 17.6 0.1 0.023 15.1 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain SPT2 PF08243.11 PIK52093.1 - 0.083 13.4 4.3 0.38 11.3 0.5 2.6 2 0 0 2 2 2 0 SPT2 chromatin protein DNA_pol3_chi PF04364.13 PIK52093.1 - 0.099 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase III chi subunit, HolC EF-G-binding_N PF07299.11 PIK52093.1 - 0.1 13.2 1.7 0.14 12.7 0.1 2.1 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal Cnd1 PF12717.7 PIK52093.1 - 0.18 11.8 2.3 1.2 9.2 0.1 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 IBR PF01485.21 PIK52094.1 - 8.6e-22 77.1 25.7 1.6e-13 50.7 12.1 2.2 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain FYVE PF01363.21 PIK52094.1 - 0.14 12.3 23.3 0.2 11.8 6.3 2.4 2 0 0 2 2 2 0 FYVE zinc finger Lon_C PF05362.13 PIK52096.1 - 2.5e-72 242.7 0.1 5e-72 241.7 0.1 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 PIK52096.1 - 4.4e-24 85.4 0.0 1.2e-23 84.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 PIK52096.1 - 4.6e-19 69.1 0.5 1.5e-18 67.5 0.1 2.0 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 PIK52096.1 - 2.1e-08 34.3 0.0 1.9e-07 31.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 PIK52096.1 - 6.5e-08 32.5 0.0 1.4e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 PIK52096.1 - 1.3e-07 31.8 1.4 1.8e-07 31.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 PIK52096.1 - 3.3e-06 26.9 0.1 7.1e-05 22.6 0.0 2.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 PIK52096.1 - 8.9e-06 24.8 0.0 1.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 PIK52096.1 - 9e-06 26.2 0.0 4.3e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 PIK52096.1 - 0.00045 20.6 0.0 0.0015 18.9 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 PIK52096.1 - 0.0014 18.9 0.0 0.039 14.2 0.0 2.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 PIK52096.1 - 0.0028 17.6 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 1 1 RsgA GTPase Parvo_NS1 PF01057.17 PIK52096.1 - 0.0039 16.3 0.3 0.024 13.7 0.0 2.3 2 1 1 3 3 2 1 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 PIK52096.1 - 0.0048 16.9 0.3 0.018 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 PIK52096.1 - 0.0063 17.1 0.7 0.044 14.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK52096.1 - 0.0075 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 PIK52096.1 - 0.012 15.5 0.0 0.048 13.5 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 PIK52096.1 - 0.012 14.8 0.0 0.028 13.6 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain MCM PF00493.23 PIK52096.1 - 0.014 14.5 0.0 0.033 13.3 0.0 1.6 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 PIK52096.1 - 0.024 14.4 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK52096.1 - 0.072 13.0 0.0 0.32 10.9 0.0 2.1 1 1 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 PIK52096.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 PIK52096.1 - 0.091 13.2 2.0 0.75 10.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 PIK52096.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 PIK52096.1 - 0.13 12.2 6.9 0.24 11.3 0.0 3.2 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 PIK52096.1 - 0.14 11.9 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK52096.1 - 0.18 12.4 0.5 0.68 10.5 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 PIK52096.1 - 0.34 11.4 5.5 6.1 7.3 0.1 2.6 2 1 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 PIK52096.1 - 0.35 10.7 2.2 0.92 9.3 0.0 2.6 3 1 0 3 3 3 0 Bacterial dnaA protein MetOD2 PF18548.1 PIK52096.1 - 5.4 7.2 7.2 2.7 8.2 2.2 2.8 3 0 0 3 3 3 0 Metanogen output domain 2 Membr_traf_MHD PF10540.9 PIK52097.1 - 4.1e-40 137.4 8.0 1.3e-39 135.7 3.0 3.1 3 1 0 3 3 3 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 PIK52097.1 - 1.6e-39 134.3 2.8 7.8e-27 93.6 0.3 3.3 3 0 0 3 3 3 2 C2 domain DUF1041 PF06292.17 PIK52097.1 - 1.7e-33 115.2 0.0 6e-33 113.4 0.0 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) CEP76-C2 PF15627.6 PIK52097.1 - 0.045 13.3 0.0 4.6 6.8 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain Imm65 PF15582.6 PIK52098.1 - 0.88 8.4 3.3 29 3.4 0.1 2.9 2 1 1 3 3 3 0 Immunity protein 65 HGWP PF03578.15 PIK52098.1 - 1 8.9 6.3 13 5.4 0.1 4.1 4 0 0 4 4 4 0 HGWP repeat Zona_pellucida PF00100.23 PIK52100.1 - 3.2e-07 30.4 0.2 4e-07 30.1 0.2 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Sushi PF00084.20 PIK52100.1 - 0.0029 18.2 3.4 0.0049 17.4 1.2 2.3 2 1 0 2 2 2 1 Sushi repeat (SCR repeat) HRM PF02793.22 PIK52100.1 - 0.14 12.5 0.7 0.14 12.5 0.7 1.7 2 0 0 2 2 2 0 Hormone receptor domain Slx4 PF09494.10 PIK52101.1 - 1.9e-07 30.9 0.0 3.7e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease BTB PF00651.31 PIK52101.1 - 0.00028 21.1 0.1 0.00066 19.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain GTP_EFTU_D4 PF14578.6 PIK52101.1 - 0.033 14.1 0.3 0.11 12.5 0.3 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 4 zf-C2H2_jaz PF12171.8 PIK52101.1 - 0.91 9.9 5.6 2.7 8.4 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK52101.1 - 2.7 8.1 6.9 0.67 10.0 0.5 3.0 3 0 0 3 3 3 0 BED zinc finger HemX PF04375.14 PIK52101.1 - 3.1 7.0 10.3 8.7 5.5 10.3 1.7 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TUDOR PF00567.24 PIK52102.1 - 1.4e-28 99.4 0.1 9.1e-15 54.8 0.3 2.8 2 1 0 2 2 2 2 Tudor domain Glyco_transf_22 PF03901.17 PIK52103.1 - 2e-09 37.2 0.1 2.2e-09 37.1 0.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.17 PIK52104.1 - 8.4e-78 262.4 24.2 9.7e-78 262.2 24.2 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family KxDL PF10241.9 PIK52106.1 - 1.9e-29 101.8 0.3 2.8e-29 101.2 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein TolA_bind_tri PF16331.5 PIK52106.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.2 3 0 0 3 3 3 0 TolA binding protein trimerisation IKI3 PF04762.12 PIK52107.1 - 1.2e-255 850.9 0.0 1.9e-255 850.3 0.0 1.2 1 0 0 1 1 1 1 IKI3 family DUF848 PF05852.11 PIK52107.1 - 0.026 14.7 0.5 0.88 9.7 0.1 2.7 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Cucumopine_C PF18631.1 PIK52107.1 - 0.045 13.7 0.3 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 Cucumopine synthase C-terminal helical bundle domain TPR_2 PF07719.17 PIK52107.1 - 0.051 13.7 1.8 8.9 6.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1759 PF03564.15 PIK52107.1 - 0.073 13.0 4.9 0.11 12.5 0.3 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1759) Clathrin PF00637.20 PIK52107.1 - 0.084 12.7 9.0 0.17 11.7 0.0 4.0 3 2 2 5 5 5 0 Region in Clathrin and VPS TPR_12 PF13424.6 PIK52107.1 - 0.11 12.8 0.1 29 5.0 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK52107.1 - 0.18 11.7 0.1 24 5.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PDZ PF00595.24 PIK52108.1 - 5.7e-27 93.9 1.8 1.8e-18 66.6 1.7 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK52108.1 - 2e-17 62.8 0.2 1.2e-10 41.1 0.1 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK52108.1 - 2e-11 44.0 0.3 7e-07 29.5 0.2 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 PIK52109.1 - 3.9e-15 56.0 2.2 0.00078 19.7 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK52109.1 - 5.4e-08 32.6 0.4 0.16 11.9 0.0 4.3 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 PIK52109.1 - 8.9e-05 22.7 0.1 7.5 7.0 0.0 3.7 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 PIK52110.1 - 3.3e-06 27.3 0.3 0.0033 17.7 0.1 2.9 2 0 0 2 2 2 2 PDZ domain RhoGEF PF00621.20 PIK52112.1 - 9.2e-36 123.8 5.8 9.2e-36 123.8 5.8 2.8 2 1 2 4 4 4 1 RhoGEF domain SH3_1 PF00018.28 PIK52112.1 - 4.2e-09 35.9 0.1 1.2e-08 34.4 0.1 1.9 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 PIK52112.1 - 2.1e-08 34.6 2.6 2.1e-08 34.6 2.6 2.6 3 0 0 3 3 3 1 PH domain SH3_2 PF07653.17 PIK52112.1 - 4.4e-08 32.7 0.1 1.2e-07 31.3 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK52112.1 - 3.2e-07 30.1 0.2 3.2e-07 30.1 0.2 1.7 2 0 0 2 2 2 1 Variant SH3 domain Spectrin PF00435.21 PIK52112.1 - 0.00074 20.0 18.6 0.0025 18.3 6.9 4.1 4 0 0 4 4 4 2 Spectrin repeat IQ_SEC7_PH PF16453.5 PIK52112.1 - 0.0012 18.8 1.4 0.0037 17.3 1.4 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 PIK52112.1 - 0.0059 16.9 1.7 0.0059 16.9 1.7 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 PIK52112.1 - 0.076 13.3 1.0 0.23 11.8 0.1 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain SH3_3 PF08239.11 PIK52112.1 - 0.11 12.7 0.6 0.36 11.1 0.6 1.9 1 0 0 1 1 1 0 Bacterial SH3 domain Beta_helix PF13229.6 PIK52113.1 - 3.8e-86 286.8 89.1 4.5e-26 91.6 10.4 5.3 1 1 5 6 6 6 5 Right handed beta helix region NosD PF05048.13 PIK52113.1 - 2.4e-34 118.7 30.8 1.6e-15 57.1 5.3 3.9 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) F-box-like PF12937.7 PIK52113.1 - 7.5e-15 54.6 0.7 1.4e-14 53.7 0.7 1.4 1 0 0 1 1 1 1 F-box-like zf-UBR PF02207.20 PIK52113.1 - 1.9e-08 34.4 12.9 1.9e-08 34.4 12.9 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.33 PIK52113.1 - 2.1e-08 33.8 0.4 4.4e-08 32.8 0.4 1.6 1 0 0 1 1 1 1 F-box domain EF-hand_7 PF13499.6 PIK52114.1 - 1e-11 45.1 2.1 1.7e-11 44.4 2.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK52114.1 - 4.7e-10 38.3 6.0 0.00012 21.3 3.6 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK52114.1 - 2.1e-09 36.5 6.1 0.00027 20.6 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 PIK52114.1 - 1.3e-08 34.5 3.7 7.4e-06 25.7 0.6 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK52114.1 - 7.8e-06 25.2 6.5 0.00034 20.0 1.2 2.7 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 PIK52114.1 - 0.0096 16.0 0.2 0.16 12.0 0.0 2.1 1 1 1 2 2 2 1 Ca2+ insensitive EF hand Imm61 PF15598.6 PIK52115.1 - 0.062 13.2 0.1 0.066 13.1 0.1 1.1 1 0 0 1 1 1 0 Immunity protein 61 7tm_1 PF00001.21 PIK52115.1 - 0.1 11.9 1.5 0.13 11.6 1.5 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2207 PF09972.9 PIK52115.1 - 0.18 10.6 1.5 0.15 10.8 1.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3043 PF11241.8 PIK52115.1 - 3.5 7.6 5.2 3.5 7.6 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Pkinase_Tyr PF07714.17 PIK52116.1 - 5.7e-92 307.6 0.0 8.2e-92 307.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52116.1 - 1.6e-39 135.9 0.1 2e-38 132.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain PPV_E2_C PF00511.17 PIK52116.1 - 0.029 14.6 0.4 0.12 12.5 0.0 2.2 3 0 0 3 3 3 0 E2 (early) protein, C terminal fn3 PF00041.21 PIK52116.1 - 0.056 13.8 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 Fibronectin type III domain Pkinase_fungal PF17667.1 PIK52116.1 - 0.078 11.7 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Staphylokinase PF02821.16 PIK52116.1 - 0.078 13.4 1.9 15 6.1 0.2 3.1 3 0 0 3 3 3 0 Staphylokinase/Streptokinase family APH PF01636.23 PIK52116.1 - 0.09 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ion_trans_2 PF07885.16 PIK52117.1 - 2.5e-20 72.2 19.4 2.9e-10 40.0 13.2 2.5 2 0 0 2 2 2 2 Ion channel WBP-1 PF11669.8 PIK52117.1 - 0.00029 21.4 0.1 0.00069 20.2 0.1 1.6 1 0 0 1 1 1 1 WW domain-binding protein 1 CytochromB561_N PF09786.9 PIK52117.1 - 0.021 13.8 2.3 0.027 13.5 2.3 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal MAAL_C PF07476.11 PIK52117.1 - 0.12 11.5 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Ion_trans PF00520.31 PIK52117.1 - 0.6 9.3 12.7 27 3.9 15.1 2.2 1 1 1 2 2 2 0 Ion transport protein LRR19-TM PF15176.6 PIK52117.1 - 0.77 9.8 2.5 0.79 9.7 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Ion_trans_2 PF07885.16 PIK52118.1 - 2.6e-27 94.6 22.5 1.3e-16 60.3 0.7 3.0 3 0 0 3 3 3 2 Ion channel WBP-1 PF11669.8 PIK52118.1 - 0.0017 18.9 0.1 0.0038 17.8 0.1 1.6 1 0 0 1 1 1 1 WW domain-binding protein 1 Lig_chan PF00060.26 PIK52118.1 - 0.018 14.9 1.7 3.7 7.4 0.0 3.0 3 0 0 3 3 3 0 Ligand-gated ion channel DUF5313 PF17240.2 PIK52118.1 - 0.4 11.1 3.3 12 6.4 0.5 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5313) Ion_trans_2 PF07885.16 PIK52119.1 - 2.1e-28 98.1 26.3 1.1e-17 63.7 1.9 3.4 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 PIK52119.1 - 4.8e-07 29.2 13.9 0.00013 21.3 1.9 2.4 2 0 0 2 2 2 2 Ion transport protein WBP-1 PF11669.8 PIK52119.1 - 0.00026 21.6 0.7 0.00074 20.1 0.1 2.0 2 0 0 2 2 2 1 WW domain-binding protein 1 IRK PF01007.20 PIK52119.1 - 0.028 14.2 9.5 0.44 10.4 0.0 3.4 3 0 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain PAS_3 PF08447.12 PIK52119.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 PAS fold KASH PF10541.9 PIK52119.1 - 1.5 9.1 4.2 2.1 8.7 0.4 2.7 2 0 0 2 2 2 0 Nuclear envelope localisation domain TFIIA PF03153.13 PIK52121.1 - 1.5e-64 219.6 54.0 6.3e-40 138.4 25.8 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Mpp10 PF04006.12 PIK52121.1 - 0.034 12.6 20.6 0.015 13.8 10.7 2.0 2 0 0 2 2 2 0 Mpp10 protein CDC45 PF02724.14 PIK52121.1 - 0.27 9.5 22.3 0.7 8.1 1.1 2.1 2 0 0 2 2 2 0 CDC45-like protein Sigma70_ner PF04546.13 PIK52121.1 - 0.36 10.7 17.7 2 8.3 11.9 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Nop14 PF04147.12 PIK52121.1 - 0.48 8.6 22.5 1.2 7.3 16.8 2.0 2 0 0 2 2 2 0 Nop14-like family Vfa1 PF08432.10 PIK52121.1 - 1.7 9.0 15.0 3.2 8.1 5.0 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.9 PIK52121.1 - 1.9 7.6 33.8 0.25 10.4 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) RSB_motif PF16294.5 PIK52121.1 - 2.2 8.6 14.1 0.081 13.2 1.4 2.3 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif BUD22 PF09073.10 PIK52121.1 - 4.2 6.6 27.9 2.6 7.3 14.1 2.1 2 0 0 2 2 2 0 BUD22 EPL1 PF10513.9 PIK52121.1 - 7.4 6.9 19.0 0.39 11.1 6.6 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like RNA_pol_Rpc4 PF05132.14 PIK52121.1 - 7.8 6.9 12.7 7 7.1 1.8 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 PIK52121.1 - 9.2 4.2 28.3 0.36 8.9 18.6 2.0 2 0 0 2 2 2 0 DNA polymerase phi 7tm_1 PF00001.21 PIK52122.1 - 1.5e-38 132.7 16.8 2e-38 132.2 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK52122.1 - 0.018 14.7 16.6 0.014 15.0 15.4 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-UBR PF02207.20 PIK52123.1 - 9e-08 32.2 7.6 1.2e-07 31.8 7.6 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.29 PIK52124.1 - 0.00017 21.4 4.9 0.00017 21.4 4.9 2.7 3 0 0 3 3 3 1 PHD-finger Hid1 PF12722.7 PIK52124.1 - 0.047 11.8 12.0 0.061 11.5 12.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 PIK52124.1 - 0.68 8.4 18.1 0.81 8.2 18.1 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 PIK52124.1 - 2.8 6.6 12.1 3.6 6.3 12.1 1.2 1 0 0 1 1 1 0 Presenilin TFR_dimer PF04253.15 PIK52125.1 - 5e-23 81.5 0.2 7e-23 81.0 0.2 1.2 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 PIK52126.1 - 5.2e-14 52.0 0.0 9.7e-14 51.2 0.0 1.3 1 0 0 1 1 1 1 PA domain NtCtMGAM_N PF16863.5 PIK52127.1 - 0.011 15.9 0.0 0.028 14.6 0.0 1.6 1 1 1 2 2 2 0 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Glyco_hydro_31 PF01055.26 PIK52128.1 - 5.8e-115 385.0 7.5 2.8e-71 241.0 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 PIK52128.1 - 1.5e-26 92.5 0.4 3.4e-25 88.2 0.1 3.0 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 PIK52128.1 - 4.2e-07 30.1 0.1 9.5e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) ADP_PFK_GK PF04587.15 PIK52129.1 - 1.3e-86 290.9 0.0 1.6e-86 290.6 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region Nitro_FeMo-Co PF02579.17 PIK52129.1 - 0.0032 17.7 0.0 0.0058 16.9 0.0 1.4 1 0 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor ERCC4 PF02732.15 PIK52130.1 - 1.8e-24 86.8 0.0 1.1e-23 84.1 0.0 2.3 2 0 0 2 2 2 1 ERCC4 domain HTH_45 PF14947.6 PIK52130.1 - 0.0038 17.2 0.0 0.0083 16.1 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 PIK52130.1 - 0.014 15.1 0.0 0.21 11.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) DUF1495 PF07381.11 PIK52130.1 - 0.027 14.3 0.0 0.098 12.5 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) KH_8 PF17903.1 PIK52130.1 - 0.14 12.3 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Krr1 KH1 domain Ig_2 PF13895.6 PIK52131.1 - 3.4e-08 33.7 0.1 5.9e-05 23.3 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK52131.1 - 9e-08 32.1 0.0 0.02 15.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK52131.1 - 1.9e-07 31.6 0.1 0.0032 18.0 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52131.1 - 1.3e-05 25.2 0.2 2.5e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK52131.1 - 0.00017 21.7 0.1 0.076 13.2 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK52131.1 - 0.011 15.9 0.2 6.3 7.0 0.1 2.7 2 1 1 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK52132.1 - 9.2e-12 45.1 2.6 8.5e-05 22.8 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.6 PIK52132.1 - 9.4e-12 45.4 2.4 0.023 15.3 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK52132.1 - 2.4e-10 40.3 2.0 0.00028 20.9 0.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK52132.1 - 2.5e-08 33.9 0.2 0.029 14.4 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK52132.1 - 4.9e-08 33.0 0.5 0.21 11.8 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK52132.1 - 2.5e-06 27.6 0.2 0.0011 19.2 0.0 3.3 3 1 0 3 3 3 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK52132.1 - 0.00037 20.8 2.0 1.2 9.6 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin C1-set domain rve PF00665.26 PIK52133.1 - 2.6e-24 85.7 0.0 4.1e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52133.1 - 6.2e-09 35.5 0.1 1.8e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK52133.1 - 0.0015 18.6 0.0 0.0033 17.5 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain BACK PF07707.15 PIK52134.1 - 1e-20 73.7 0.2 2.9e-20 72.3 0.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 PIK52134.1 - 3.2e-20 72.4 0.2 2.6e-19 69.5 0.2 2.2 1 1 0 1 1 1 1 BTB/POZ domain F5_F8_type_C PF00754.25 PIK52134.1 - 4.4e-19 68.9 0.2 1.8e-09 37.8 0.1 2.2 2 0 0 2 2 2 2 F5/8 type C domain DUF575 PF04746.12 PIK52134.1 - 0.041 14.1 0.0 15 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF575) Pkinase PF00069.25 PIK52136.1 - 1.6e-10 40.8 0.1 2.6e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52136.1 - 2.3e-09 37.0 0.3 4e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK52136.1 - 0.00036 19.9 0.3 0.00063 19.2 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.21 PIK52136.1 - 0.46 9.8 16.8 1.3 8.2 16.7 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2393 PF09624.10 PIK52136.1 - 4.3 7.3 7.6 2.6 8.0 1.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) Phage_Gp23 PF10669.9 PIK52136.1 - 9.7 6.5 11.9 0.15 12.4 0.4 3.4 3 1 1 4 4 4 0 Protein gp23 (Bacteriophage A118) TUDOR PF00567.24 PIK52137.1 - 4.9e-16 58.9 0.0 1e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Helicase_C PF00271.31 PIK52137.1 - 2.9e-12 46.9 0.1 6.4e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 PIK52137.1 - 9.3e-07 29.1 0.1 9.3e-07 29.1 0.1 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) START PF01852.19 PIK52138.1 - 4e-07 29.7 0.0 1.3e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 START domain Svs_4_5_6 PF17381.2 PIK52138.1 - 0.55 11.2 5.5 1.5 9.9 5.5 1.7 1 0 0 1 1 1 0 Seminal vesicle secretory proteins 4/5/6 Ank_5 PF13857.6 PIK52139.1 - 5.1e-19 68.1 1.1 2.1e-07 31.1 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK52139.1 - 1.3e-17 64.2 0.8 7.4e-12 45.7 0.2 3.6 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK52139.1 - 2.3e-14 53.5 0.5 3e-09 37.3 0.1 4.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK52139.1 - 3.2e-14 52.6 3.3 0.00044 20.6 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 PIK52139.1 - 5e-14 51.0 0.9 0.007 16.8 0.1 5.2 5 0 0 5 5 5 3 Ankyrin repeat Glyco_hydro_20b PF02838.15 PIK52139.1 - 1.2e-08 35.8 0.0 2.7e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 PIK52139.1 - 0.061 12.7 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain RT_RNaseH_2 PF17919.1 PIK52140.1 - 2e-36 124.0 0.0 4.8e-36 122.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CPSF100_C PF13299.6 PIK52140.1 - 1.4e-34 119.8 0.1 1.4e-34 119.8 0.1 3.8 4 0 0 4 4 4 1 Cleavage and polyadenylation factor 2 C-terminal RT_RNaseH PF17917.1 PIK52140.1 - 4e-23 81.7 0.0 8.7e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK52140.1 - 2.1e-21 75.8 0.3 4e-21 74.9 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK52140.1 - 1.1e-19 70.8 0.0 2.5e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK52140.1 - 2.9e-18 66.2 0.0 6.2e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Beta-Casp PF10996.8 PIK52140.1 - 1.3e-10 41.5 0.0 5.4e-10 39.5 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 PIK52140.1 - 1.7e-10 40.7 0.0 3.9e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain zf-H2C2 PF09337.10 PIK52140.1 - 7.9e-07 29.2 0.0 1.8e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK52140.1 - 0.012 15.3 0.0 0.033 14.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 PIK52141.1 - 9.9e-29 99.3 0.0 2e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52141.1 - 1.8e-25 89.8 0.0 4.6e-25 88.4 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK52141.1 - 3.7e-16 59.3 0.0 6.9e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK52142.1 - 2.1e-19 69.8 0.0 3.2e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52142.1 - 0.0018 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK52142.1 - 0.049 13.9 0.0 0.078 13.2 0.0 1.2 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK52144.1 - 5.8e-22 78.3 0.0 7.3e-22 78.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) G_glu_transpept PF01019.21 PIK52145.1 - 5.9e-133 444.3 0.0 1.1e-131 440.1 0.0 2.0 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 PIK52146.1 - 2.9e-19 69.2 0.1 3.1e-19 69.1 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RRM_1 PF00076.22 PIK52147.1 - 7.2e-11 41.8 0.1 0.00019 21.2 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDA1 PF05285.12 PIK52147.1 - 8.5e-05 22.1 17.6 0.00011 21.8 17.6 1.2 1 0 0 1 1 1 1 SDA1 DUF4604 PF15377.6 PIK52147.1 - 0.00012 22.6 15.8 0.00016 22.1 15.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Nop14 PF04147.12 PIK52147.1 - 0.0095 14.2 25.2 0.012 13.8 25.2 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 PIK52147.1 - 0.029 12.7 16.2 0.038 12.3 16.2 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 PIK52147.1 - 0.11 11.9 23.3 0.16 11.3 23.3 1.3 1 0 0 1 1 1 0 BUD22 YL1 PF05764.13 PIK52147.1 - 0.56 10.3 23.6 0.031 14.4 18.4 1.6 2 0 0 2 2 2 0 YL1 nuclear protein SAPS PF04499.15 PIK52147.1 - 2.1 7.0 12.1 2.9 6.6 12.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ECSIT_C PF14784.6 PIK52147.1 - 3.4 8.0 7.0 0.51 10.7 1.1 2.3 1 1 1 2 2 2 0 C-terminal domain of the ECSIT protein SRF-TF PF00319.18 PIK52148.1 - 4.4e-20 70.9 0.1 7.3e-20 70.2 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SSF PF00474.17 PIK52149.1 - 6.4e-13 48.3 0.4 8.8e-13 47.9 0.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family N2227 PF07942.12 PIK52150.1 - 4e-91 305.0 0.0 4.4e-91 304.8 0.0 1.0 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 PIK52150.1 - 0.0058 17.3 0.0 0.044 14.4 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK52150.1 - 0.0097 15.8 0.0 0.024 14.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK52150.1 - 0.063 14.0 0.0 0.34 11.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 PIK52150.1 - 0.21 12.3 0.0 5 7.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain GGACT PF06094.12 PIK52151.1 - 1.9e-09 38.2 0.0 2.5e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK52151.1 - 0.049 14.0 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family ATP1G1_PLM_MAT8 PF02038.16 PIK52151.1 - 0.16 11.4 0.2 0.3 10.6 0.2 1.4 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family SPACA9 PF15120.6 PIK52152.1 - 1.9e-07 31.0 1.2 1e-06 28.6 0.9 2.1 1 1 0 1 1 1 1 Sperm acrosome-associated protein 9 Pkinase PF00069.25 PIK52153.1 - 8.5e-76 254.8 0.0 9.6e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52153.1 - 1.2e-35 123.0 0.0 1.7e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK52153.1 - 0.0002 21.4 0.3 0.00061 19.8 0.4 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 PIK52153.1 - 0.00023 20.6 0.5 0.043 13.1 0.2 2.4 1 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 PIK52153.1 - 0.00032 19.8 0.0 0.015 14.2 0.0 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK52153.1 - 0.0057 16.0 0.8 0.014 14.8 0.3 1.8 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 PIK52153.1 - 0.087 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Vps39_2 PF10367.9 PIK52153.1 - 0.18 12.3 0.2 0.27 11.7 0.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 LEDGF PF11467.8 PIK52154.1 - 6.7e-23 80.6 1.6 6.7e-23 80.6 1.6 3.0 2 0 0 2 2 2 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.17 PIK52154.1 - 5.5e-10 39.5 0.5 5.5e-10 39.5 0.5 6.5 5 2 0 5 5 5 1 PWWP domain GST_N_3 PF13417.6 PIK52155.1 - 9.6e-22 77.2 0.0 1.6e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 PIK52155.1 - 2.7e-15 56.5 0.1 4.1e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK52155.1 - 6.1e-13 48.9 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK52155.1 - 6.7e-07 29.2 0.0 2.6e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 PIK52155.1 - 0.00038 20.6 0.0 0.00073 19.7 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.25 PIK52155.1 - 0.023 14.9 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK52155.1 - 0.098 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK52156.1 - 7.4e-21 74.3 0.0 1.2e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK52156.1 - 9.3e-15 54.7 0.0 2e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 PIK52156.1 - 9.6e-14 51.5 0.1 2.1e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 PIK52156.1 - 0.00014 22.0 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin DUF5375 PF17345.2 PIK52156.1 - 0.037 13.9 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5375) FMN_dh PF01070.18 PIK52157.1 - 5.6e-79 265.7 0.0 8.7e-79 265.1 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK52157.1 - 3.6e-08 32.8 0.0 5.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK52157.1 - 3.7e-05 23.0 0.2 5.9e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 PIK52157.1 - 0.0015 17.9 0.1 0.6 9.4 0.0 2.8 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 PIK52157.1 - 0.053 12.9 0.3 0.083 12.3 0.3 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase TMP-TENI PF02581.17 PIK52157.1 - 0.16 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase LapA_dom PF06305.11 PIK52158.1 - 0.00036 20.3 0.1 0.00065 19.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain VirB8 PF04335.13 PIK52158.1 - 0.054 13.3 0.7 0.11 12.3 0.7 1.5 1 0 0 1 1 1 0 VirB8 protein DUF347 PF03988.12 PIK52158.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) TMEM154 PF15102.6 PIK52159.1 - 4.6e-05 23.3 5.6 8.6e-05 22.5 4.6 2.0 1 1 0 1 1 1 1 TMEM154 protein family AJAP1_PANP_C PF15298.6 PIK52159.1 - 0.0029 17.9 5.6 0.0029 17.9 5.6 1.6 2 0 0 2 2 2 1 AJAP1/PANP C-terminus Herpes_U44 PF04533.13 PIK52159.1 - 0.057 13.0 0.1 2.6 7.6 0.0 2.6 3 0 0 3 3 3 0 Herpes virus U44 protein Mucin PF01456.17 PIK52159.1 - 0.44 10.5 14.6 0.042 13.9 9.2 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein ATG11 PF10377.9 PIK52160.1 - 0.00099 19.2 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 11 ResIII PF04851.15 PIK52160.1 - 0.0058 16.6 0.1 0.014 15.4 0.1 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit FAD_binding_8 PF08022.12 PIK52160.1 - 0.0074 16.4 0.0 0.016 15.3 0.0 1.5 1 1 0 1 1 1 1 FAD-binding domain RVT_1 PF00078.27 PIK52160.1 - 0.0089 15.6 0.1 0.029 13.9 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MLVIN_C PF18697.1 PIK52160.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Phage_TAC_8 PF10666.9 PIK52160.1 - 0.11 12.8 0.4 0.31 11.3 0.4 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Gp14 ()A118 rve PF00665.26 PIK52161.1 - 6.3e-20 71.5 0.0 7.5e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52161.1 - 0.0018 18.0 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK52161.1 - 0.024 14.8 0.0 0.03 14.6 0.0 1.1 1 0 0 1 1 1 0 DDE domain TMEM154 PF15102.6 PIK52163.1 - 3e-05 23.9 1.8 3e-05 23.9 1.8 2.4 2 1 0 2 2 2 1 TMEM154 protein family Mucin PF01456.17 PIK52163.1 - 0.0065 16.5 6.5 0.0065 16.5 6.5 2.2 3 0 0 3 3 3 1 Mucin-like glycoprotein RVT_1 PF00078.27 PIK52164.1 - 7.5e-20 71.4 0.1 2.7e-19 69.6 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK52165.1 - 7e-22 77.3 0.4 1.2e-21 76.6 0.4 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK52165.1 - 2e-07 31.1 0.0 3.8e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger SCAN PF02023.17 PIK52166.1 - 4.7e-15 55.2 0.4 1.4e-14 53.6 0.4 1.9 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK52166.1 - 1.3e-05 25.0 1.0 2.7e-05 24.0 1.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK52166.1 - 0.0053 16.5 0.7 0.0095 15.7 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle MDM1 PF15501.6 PIK52166.1 - 0.044 13.0 11.0 0.074 12.2 11.0 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 zf-CCHC_5 PF14787.6 PIK52166.1 - 0.21 11.3 2.4 0.48 10.2 2.4 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger KfrA_N PF11740.8 PIK52166.1 - 4 8.1 14.5 11 6.7 14.5 1.8 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF3987 PF13148.6 PIK52166.1 - 8.8 5.2 11.0 2 7.3 6.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3987) TMEM154 PF15102.6 PIK52167.1 - 3.2e-05 23.9 1.6 3.2e-05 23.9 1.6 2.3 2 1 0 2 2 2 1 TMEM154 protein family Mucin PF01456.17 PIK52167.1 - 0.0053 16.8 6.7 0.0053 16.8 6.7 2.0 2 1 0 2 2 2 1 Mucin-like glycoprotein CAV_VP3 PF04771.12 PIK52168.1 - 0.15 12.2 0.4 0.35 11.0 0.4 1.6 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein RT_RNaseH_2 PF17919.1 PIK52169.1 - 4e-38 129.5 0.0 6.8e-38 128.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52169.1 - 7.7e-38 129.0 0.0 1.2e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52169.1 - 1e-07 31.7 0.1 4.1e-05 23.2 0.1 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK52170.1 - 3.5e-13 49.8 0.0 5.6e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52170.1 - 0.0014 18.4 0.0 0.0031 17.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK52172.1 - 2.9e-15 55.8 0.4 5.3e-15 55.0 0.4 1.4 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK52172.1 - 0.00092 19.4 1.5 0.0078 16.5 0.1 2.7 2 1 1 3 3 3 1 Retrotransposon gag protein SCAN PF02023.17 PIK52173.1 - 1.8e-06 27.6 0.4 3.3e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 SCAN domain zf-CCHC_3 PF13917.6 PIK52173.1 - 0.00072 19.5 0.0 0.0019 18.1 0.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK52173.1 - 0.0029 17.6 1.4 0.0055 16.7 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK52173.1 - 0.069 13.0 1.0 0.24 11.3 0.2 2.2 2 0 0 2 2 2 0 Zinc knuckle Sulfotransfer_1 PF00685.27 PIK52174.1 - 8.9e-53 179.5 0.7 1.1e-52 179.2 0.7 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK52174.1 - 5.2e-06 27.0 0.3 0.0055 17.1 0.1 3.2 2 1 0 2 2 2 2 Sulfotransferase family AcylCoA_dehyd_C PF12186.8 PIK52174.1 - 0.064 13.4 0.3 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal Exo_endo_phos_2 PF14529.6 PIK52175.1 - 0.00017 21.4 0.1 0.00033 20.5 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase T4-Gluco-transf PF09198.10 PIK52175.1 - 0.14 11.8 0.4 0.14 11.8 0.4 1.9 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase Pkinase_Tyr PF07714.17 PIK52176.1 - 5.3e-10 39.0 0.0 6.1e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52176.1 - 3.1e-08 33.3 0.0 4e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Fusion_gly_K PF01621.17 PIK52176.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Cell fusion glycoprotein K Ig_3 PF13927.6 PIK52177.1 - 5.2e-09 36.6 12.0 0.0018 18.9 0.7 4.3 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK52177.1 - 1.3e-08 34.8 1.6 0.004 17.2 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK52177.1 - 1e-06 28.8 9.9 0.0072 16.5 0.6 3.8 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK52177.1 - 3.1e-06 27.4 14.2 0.0042 17.4 1.3 3.8 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK52177.1 - 9.8e-05 22.5 9.7 0.24 11.6 0.2 4.3 2 2 1 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK52177.1 - 0.00048 20.3 14.0 0.81 10.0 5.0 4.6 3 2 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK52177.1 - 0.0079 15.7 1.0 0.84 9.2 0.2 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK52177.1 - 0.018 15.1 8.2 0.33 11.0 1.8 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK52177.1 - 0.021 15.2 12.8 1.3 9.4 1.4 3.4 2 2 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK52177.1 - 0.12 12.5 0.6 0.65 10.1 0.0 2.4 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK52177.1 - 0.61 9.9 13.0 0.46 10.3 1.7 3.5 2 2 0 2 2 2 0 Adenovirus E3 region protein CR1 RVT_1 PF00078.27 PIK52178.1 - 1.7e-13 50.6 0.0 4.2e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK52178.1 - 4.7e-08 32.9 0.0 1.1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ig PF00047.25 PIK52179.1 - 0.0036 17.4 0.1 0.026 14.7 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 PIK52179.1 - 0.012 15.2 0.5 0.12 11.9 0.5 2.2 1 1 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 PIK52179.1 - 0.02 15.2 0.4 0.091 13.1 0.1 2.1 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK52179.1 - 0.021 15.0 0.1 0.042 14.0 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52179.1 - 0.056 14.0 1.6 0.22 12.1 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK52179.1 - 0.06 13.4 0.2 0.4 10.8 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin I-set domain Izumo-Ig PF16706.5 PIK52179.1 - 0.07 13.2 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain tRNA_m1G_MT PF01746.21 PIK52180.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.5 2 0 0 2 2 2 0 tRNA (Guanine-1)-methyltransferase Phage_int_SAM_1 PF02899.17 PIK52180.1 - 0.037 14.3 0.5 0.14 12.5 0.2 2.1 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF1902 PF08972.11 PIK52180.1 - 0.061 13.3 0.4 7.2 6.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) Aph-1 PF06105.12 PIK52181.1 - 7.3e-43 146.6 1.2 8.8e-43 146.3 1.2 1.0 1 0 0 1 1 1 1 Aph-1 protein Laminin_EGF PF00053.24 PIK52183.1 - 6e-91 298.4 236.1 9.5e-12 44.9 13.0 12.8 11 1 1 12 12 12 12 Laminin EGF domain Laminin_N PF00055.17 PIK52183.1 - 1.8e-72 243.7 0.0 1.8e-72 243.7 0.0 2.8 3 0 0 3 3 1 1 Laminin N-terminal (Domain VI) F5_F8_type_C PF00754.25 PIK52183.1 - 0.00096 19.3 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain GARP PF16731.5 PIK52183.1 - 0.002 17.9 15.6 0.002 17.9 15.6 4.4 2 2 4 6 6 6 1 Glutamic acid/alanine-rich protein of Trypanosoma Fib_alpha PF08702.10 PIK52183.1 - 0.029 14.6 24.1 2.8 8.1 0.6 4.9 2 2 1 4 4 4 0 Fibrinogen alpha/beta chain family EzrA PF06160.12 PIK52183.1 - 0.3 9.2 35.2 0.038 12.2 1.6 4.1 2 2 1 4 4 4 0 Septation ring formation regulator, EzrA DUF1664 PF07889.12 PIK52183.1 - 0.37 10.8 25.3 0.37 10.8 0.7 5.3 2 2 2 6 6 6 0 Protein of unknown function (DUF1664) AcylCoA_dehyd_C PF12186.8 PIK52183.1 - 0.96 9.6 5.8 28 4.9 0.0 4.1 3 1 0 3 3 3 0 Acyl-CoA dehydrogenase C terminal Spc7 PF08317.11 PIK52183.1 - 1.1 8.1 47.9 0.004 16.1 4.9 4.3 2 2 1 4 4 4 0 Spc7 kinetochore protein HSBP1 PF06825.12 PIK52183.1 - 2.4 8.1 5.4 13 5.7 0.2 4.2 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 PIK52183.1 - 2.6 8.1 25.1 1.5 8.8 0.6 4.7 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2730 PF10805.8 PIK52183.1 - 4.7 7.4 6.7 2.7 8.1 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2730) TMPIT PF07851.13 PIK52183.1 - 5.9 6.0 22.1 0.089 12.0 1.9 3.9 1 1 3 4 4 4 0 TMPIT-like protein Laminin_II PF06009.12 PIK52183.1 - 9.3 6.3 40.2 0.27 11.2 0.6 5.6 2 2 4 6 6 6 0 Laminin Domain II Peptidase_M20 PF01546.28 PIK52184.1 - 1.5e-28 100.0 0.0 2e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 PIK52184.1 - 1.1e-09 38.2 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Aldedh PF00171.22 PIK52185.1 - 6.9e-172 572.1 0.1 8.6e-172 571.8 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_C PF02911.18 PIK52185.1 - 4.3e-14 52.6 0.0 1e-13 51.3 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Formyl_trans_N PF00551.19 PIK52185.1 - 9e-11 41.8 0.0 1.6e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase PP-binding PF00550.25 PIK52185.1 - 4.7e-08 33.3 0.0 9.9e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1487 PF07368.11 PIK52185.1 - 0.0057 16.1 0.2 0.014 14.8 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) MMM1 PF10296.9 PIK52186.1 - 0.3 10.1 2.8 1.8 7.6 0.4 2.0 1 1 1 2 2 2 0 Maintenance of mitochondrial morphology protein 1 AARP2CN PF08142.12 PIK52187.1 - 8.3e-25 86.7 0.0 2.2e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Snurportin1 PF11538.8 PIK52187.1 - 1.6 9.0 10.0 5.4 7.3 10.0 1.9 1 0 0 1 1 1 0 Snurportin1 DNA_pol_phi PF04931.13 PIK52187.1 - 2.1 6.3 13.9 4.2 5.3 13.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 PIK52187.1 - 3.3 8.2 15.0 9.6 6.7 15.0 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RIBIOP_C PF04950.12 PIK52188.1 - 9.2e-63 212.4 0.1 1.1e-62 212.1 0.1 1.0 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal p450 PF00067.22 PIK52189.1 - 1.1e-52 179.4 0.0 1.2e-52 179.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Filamin PF00630.19 PIK52190.1 - 6.3e-135 441.3 10.4 6.3e-21 75.1 0.1 9.2 9 0 0 9 9 9 9 Filamin/ABP280 repeat Big_3_5 PF16640.5 PIK52190.1 - 3.4e-08 33.5 5.0 1.2 9.3 0.0 7.0 7 1 2 9 9 9 2 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 PIK52190.1 - 3.5e-08 33.3 7.3 0.19 11.7 0.1 5.8 6 0 0 6 6 6 3 Y_Y_Y domain DUF5060 PF16586.5 PIK52190.1 - 8.8e-08 32.4 0.4 7.3 7.1 0.0 7.3 9 0 0 9 9 9 2 Domain of unknown function (DUF5060) Invasin_D3 PF09134.10 PIK52190.1 - 9.7e-06 25.8 1.0 4.1 7.8 0.1 6.5 6 0 0 6 6 6 1 Invasin, domain 3 YtkA PF13115.6 PIK52190.1 - 0.00013 22.5 5.3 24 5.6 0.0 7.3 9 1 1 10 10 10 0 YtkA-like PKD PF00801.20 PIK52190.1 - 0.00045 20.0 5.6 2.7 7.9 0.3 6.2 5 0 0 5 5 5 1 PKD domain Big_1 PF02369.16 PIK52190.1 - 0.0062 16.5 0.5 4 7.5 0.0 4.8 6 0 0 6 6 6 1 Bacterial Ig-like domain (group 1) DAP_epimerase PF01678.19 PIK52190.1 - 0.049 13.8 0.0 0.33 11.1 0.0 2.4 2 0 0 2 2 2 0 Diaminopimelate epimerase DUF2141 PF09912.9 PIK52190.1 - 0.082 12.8 0.1 12 5.8 0.0 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2141) Filamin PF00630.19 PIK52191.1 - 1e-06 29.5 0.0 1.6e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat FG-GAP PF01839.23 PIK52191.1 - 0.12 12.6 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 FG-GAP repeat SH3_2 PF07653.17 PIK52193.1 - 2.8e-18 65.3 0.6 1.3e-10 40.8 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.6 PIK52193.1 - 5.4e-14 51.8 0.3 1.2e-09 37.8 0.1 5.5 4 2 0 4 4 4 3 Variant SH3 domain SH3_1 PF00018.28 PIK52193.1 - 6.3e-13 48.1 0.1 4.6e-10 39.0 0.0 3.5 3 1 0 3 3 3 2 SH3 domain hSH3 PF14603.6 PIK52193.1 - 3.2e-08 33.9 0.0 0.00019 21.8 0.0 3.1 3 0 0 3 3 3 2 Helically-extended SH3 domain ECH_1 PF00378.20 PIK52194.1 - 6.9e-12 45.2 0.0 8e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase zf-B_box PF00643.24 PIK52196.1 - 0.0091 16.1 4.2 0.042 14.0 0.9 2.6 2 0 0 2 2 2 1 B-box zinc finger Baculo_PEP_C PF04513.12 PIK52196.1 - 0.012 15.6 1.8 0.035 14.1 1.8 1.8 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4745 PF15923.5 PIK52196.1 - 0.014 15.3 0.2 0.038 14.0 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4745) DUF4449 PF14613.6 PIK52196.1 - 0.17 12.0 5.0 0.27 11.3 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Apolipoprotein PF01442.18 PIK52196.1 - 0.2 11.5 7.7 0.32 10.9 7.7 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ANAPC15 PF15243.6 PIK52196.1 - 0.41 11.1 3.6 0.68 10.4 2.8 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 15 FUSC PF04632.12 PIK52196.1 - 0.65 8.5 1.8 0.83 8.1 1.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Exonuc_VII_L PF02601.15 PIK52196.1 - 0.73 9.3 6.0 1.1 8.8 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FeoB_Cyto PF17910.1 PIK52196.1 - 0.96 10.0 6.2 0.45 11.1 3.1 2.0 2 0 0 2 2 2 0 FeoB cytosolic helical domain Peptidase_M2 PF01401.18 PIK52196.1 - 3.4 6.2 8.8 0.88 8.1 5.6 1.6 2 0 0 2 2 2 0 Angiotensin-converting enzyme FlgN PF05130.12 PIK52196.1 - 3.5 8.1 11.6 11 6.6 10.6 2.2 1 1 0 1 1 1 0 FlgN protein DUF883 PF05957.13 PIK52196.1 - 9 7.0 6.8 26 5.5 2.8 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) RVT_1 PF00078.27 PIK52197.1 - 1.1e-17 64.3 0.0 3.2e-13 49.7 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Gp_dh_C PF02800.20 PIK52197.1 - 0.05 13.2 0.1 0.077 12.6 0.1 1.2 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain SH2 PF00017.24 PIK52198.1 - 2.8e-15 56.1 0.0 4.5e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 SH2 domain hSH3 PF14603.6 PIK52198.1 - 1.8e-05 25.1 0.0 2.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Helically-extended SH3 domain SH2_2 PF14633.6 PIK52198.1 - 1.8e-05 24.2 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK52198.1 - 0.0077 15.8 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain CMS1 PF14617.6 PIK52198.1 - 0.22 10.8 0.0 0.3 10.4 0.0 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit C1q PF00386.21 PIK52199.1 - 2.3e-25 89.2 2.7 5.9e-25 87.9 2.7 1.7 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 PIK52199.1 - 0.02 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 BclA C-terminal domain Ribosomal_S2 PF00318.20 PIK52199.1 - 0.036 13.3 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 Spc7 PF08317.11 PIK52199.1 - 0.053 12.4 0.4 0.083 11.8 0.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein PilJ PF13675.6 PIK52199.1 - 0.11 12.5 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Styelin PF17562.2 PIK52199.1 - 0.67 10.4 2.6 3.4 8.1 1.6 2.4 1 1 1 2 2 2 0 Styelin DUF3886 PF13025.6 PIK52200.1 - 0.013 15.7 1.6 0.013 15.7 1.6 4.6 4 1 0 4 4 4 0 Protein of unknown function (DUF3886) DUF1677 PF07911.13 PIK52200.1 - 4.7 7.7 5.7 2.1 8.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1677) CTP_transf_like PF01467.26 PIK52201.1 - 1.7e-29 102.9 0.0 3.7e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like DNA_pol_B PF00136.21 PIK52202.1 - 1.3e-105 353.8 1.8 4e-95 319.2 3.9 2.2 1 1 1 2 2 2 2 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 PIK52202.1 - 1.5e-39 136.1 0.0 3.4e-39 134.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 PIK52202.1 - 1.2e-33 116.4 4.4 8.9e-32 110.3 4.4 2.7 1 1 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_alpha_N PF12254.8 PIK52202.1 - 2.9e-19 68.9 9.2 9.1e-19 67.3 9.2 2.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Spermine_synth PF01564.17 PIK52202.1 - 0.0032 16.9 0.1 0.0071 15.8 0.1 1.5 1 0 0 1 1 1 1 Spermine/spermidine synthase domain DUF1744 PF08490.12 PIK52202.1 - 0.0076 14.9 1.3 0.016 13.8 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) GvpG PF05120.12 PIK52202.1 - 0.063 13.3 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Gas vesicle protein G SLS PF14611.6 PIK52202.1 - 0.18 11.6 0.4 12 5.7 0.1 2.5 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Rotamase PF00639.21 PIK52202.1 - 0.94 10.5 3.8 31 5.6 0.8 3.4 3 0 0 3 3 3 0 PPIC-type PPIASE domain DUF4927 PF16279.5 PIK52202.1 - 2 9.5 7.8 0.45 11.6 0.5 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4927) Arm PF00514.23 PIK52203.1 - 9.7e-82 266.8 16.5 1.1e-12 47.5 0.1 8.9 8 1 1 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 PIK52203.1 - 1.6e-23 82.0 2.2 7.8e-21 73.4 0.4 3.7 5 0 0 5 5 5 1 Atypical Arm repeat HEAT_EZ PF13513.6 PIK52203.1 - 7.3e-22 77.5 0.7 2e-05 25.0 0.0 6.3 4 2 2 6 6 6 6 HEAT-like repeat IBB PF01749.20 PIK52203.1 - 2.2e-15 56.9 4.2 6.8e-15 55.3 4.2 1.8 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 PIK52203.1 - 2.1e-14 53.6 1.1 7.5e-05 23.0 0.0 4.7 2 2 3 5 5 5 5 HEAT repeats HEAT PF02985.22 PIK52203.1 - 5.6e-14 51.1 1.3 0.037 14.3 0.0 5.5 6 0 0 6 6 4 3 HEAT repeat Arm_2 PF04826.13 PIK52203.1 - 1e-08 35.0 0.7 0.25 10.8 0.4 3.7 2 1 0 3 3 3 3 Armadillo-like Adaptin_N PF01602.20 PIK52203.1 - 1.3e-08 33.9 0.0 3.1e-06 26.0 0.0 2.6 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 PIK52203.1 - 5.8e-06 26.4 2.8 0.11 12.7 0.0 3.9 4 1 1 5 5 5 3 V-ATPase subunit H Cnd1 PF12717.7 PIK52203.1 - 4e-05 23.7 0.2 1.5 8.9 0.1 3.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 PIK52203.1 - 0.016 15.3 1.0 0.78 9.8 0.1 2.9 3 0 0 3 3 3 0 Parkin co-regulated protein RTP1_C1 PF10363.9 PIK52203.1 - 0.017 15.3 0.1 17 5.6 0.0 3.5 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 FANCI_S3 PF14677.6 PIK52203.1 - 0.034 13.8 0.0 0.085 12.6 0.0 1.6 1 0 0 1 1 1 0 FANCI solenoid 3 Atx10homo_assoc PF09759.9 PIK52203.1 - 0.043 13.8 1.2 4.8 7.3 0.0 3.9 2 1 3 5 5 5 0 Spinocerebellar ataxia type 10 protein domain DCB PF16213.5 PIK52203.1 - 0.045 13.4 0.5 0.23 11.1 0.0 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Mo25 PF08569.11 PIK52203.1 - 0.058 12.8 0.0 0.85 8.9 0.0 2.2 1 1 1 2 2 2 0 Mo25-like RMI1_C PF16099.5 PIK52203.1 - 0.063 13.1 0.0 0.75 9.6 0.0 2.2 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold DRIM PF07539.12 PIK52203.1 - 0.077 11.3 0.5 0.4 8.9 0.2 2.0 1 1 0 2 2 2 0 Down-regulated in metastasis TINF2_N PF14973.6 PIK52203.1 - 0.089 13.1 0.0 2.6 8.4 0.0 2.7 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus CTNNBL PF08216.11 PIK52203.1 - 0.33 11.1 2.5 2.1 8.6 0.2 3.4 4 1 1 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear Pkinase PF00069.25 PIK52204.1 - 2.6e-46 158.2 0.0 5.3e-46 157.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain L27 PF02828.16 PIK52204.1 - 8.6e-25 86.3 14.1 1.6e-14 53.4 0.4 3.6 4 0 0 4 4 3 2 L27 domain Pkinase_Tyr PF07714.17 PIK52204.1 - 3.1e-17 62.7 0.0 5.4e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.24 PIK52204.1 - 9.6e-17 61.1 0.2 1.9e-16 60.2 0.2 1.5 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 PIK52204.1 - 9.5e-10 38.0 0.0 2.4e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK52204.1 - 2.3e-08 33.5 0.5 9.7e-08 31.5 0.5 2.1 1 1 0 1 1 1 1 SH3 domain Pkinase_fungal PF17667.1 PIK52204.1 - 2.1e-05 23.5 0.0 4.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase PDZ_6 PF17820.1 PIK52204.1 - 0.0011 18.8 0.1 0.003 17.4 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK52204.1 - 0.0019 18.5 0.1 0.0088 16.3 0.0 2.1 3 0 0 3 3 3 1 PDZ domain SH3_9 PF14604.6 PIK52204.1 - 0.0023 17.8 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.6 PIK52204.1 - 0.0046 16.3 0.0 0.0075 15.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 PIK52204.1 - 0.057 12.9 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Guanylate_kin PF00625.21 PIK52205.1 - 1.7e-52 177.7 0.0 2.4e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase PH PF00169.29 PIK52206.1 - 2e-08 34.7 0.0 4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK52206.1 - 0.052 14.0 0.0 0.11 13.0 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain TNF PF00229.18 PIK52208.1 - 5.4e-09 36.1 0.1 2e-07 31.0 0.1 2.3 1 1 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.21 PIK52208.1 - 0.077 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 C1q domain Auts2 PF15336.6 PIK52208.1 - 0.1 12.7 4.6 0.18 11.9 4.6 1.3 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein TNF PF00229.18 PIK52209.1 - 0.00025 21.0 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.18 PIK52210.1 - 1.5e-08 34.6 0.1 3.9e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family L6_membrane PF05805.12 PIK52210.1 - 0.034 13.7 0.1 0.069 12.7 0.1 1.4 1 0 0 1 1 1 0 L6 membrane protein MTABC_N PF16185.5 PIK52210.1 - 0.1 12.0 0.4 0.2 11.1 0.2 1.4 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region FACT-Spt16_Nlob PF14826.6 PIK52210.1 - 0.15 11.8 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain OapA_N PF08525.11 PIK52210.1 - 0.21 11.6 3.5 0.35 10.9 3.5 1.3 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif zf-rbx1 PF12678.7 PIK52211.1 - 6.4e-17 61.6 19.2 1.4e-15 57.3 13.9 2.2 1 1 1 2 2 2 2 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 PIK52211.1 - 4.3e-12 45.9 20.0 3.5e-08 33.4 10.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 PIK52211.1 - 8.1e-09 35.7 18.6 2.7e-07 30.8 13.4 2.2 1 1 1 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 PIK52211.1 - 0.00094 19.0 13.3 0.00094 19.0 13.3 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK52211.1 - 0.0096 15.8 18.8 0.04 13.8 12.6 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK52211.1 - 0.021 14.7 18.0 0.28 11.1 17.7 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK52211.1 - 0.081 12.8 14.5 0.21 11.5 10.9 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK52211.1 - 0.68 10.0 21.0 40 4.3 21.4 2.4 1 1 1 2 2 2 0 zinc-RING finger domain Prok-RING_1 PF14446.6 PIK52211.1 - 0.71 9.8 16.4 0.45 10.5 5.4 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Toxin_13 PF07822.11 PIK52211.1 - 2.5 8.3 18.2 0.43 10.8 7.2 2.7 1 1 2 3 3 3 0 Neurotoxin B-IV-like protein zf-RING_11 PF17123.5 PIK52211.1 - 4 7.3 19.5 0.33 10.7 7.2 2.6 3 0 0 3 3 2 0 RING-like zinc finger PHD PF00628.29 PIK52211.1 - 4.1 7.4 20.0 7.5 6.5 13.7 2.6 1 1 1 2 2 2 0 PHD-finger AA_permease_2 PF13520.6 PIK52212.1 - 3.7e-41 141.3 17.4 3.7e-41 141.3 17.4 2.1 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 PIK52212.1 - 2.3e-19 69.4 18.7 2.9e-19 69.0 18.7 1.2 1 0 0 1 1 1 1 Amino acid permease HLH PF00010.26 PIK52213.1 - 1.2e-09 38.0 0.9 2.9e-09 36.8 0.9 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 PIK52213.1 - 0.0087 16.5 1.9 0.03 14.8 1.9 1.9 1 0 0 1 1 1 1 Cell division protein ZapB APG6_N PF17675.1 PIK52213.1 - 0.0088 16.6 4.2 0.018 15.6 4.2 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region DivIC PF04977.15 PIK52213.1 - 0.014 15.1 0.7 0.033 13.9 0.7 1.6 1 0 0 1 1 1 0 Septum formation initiator Snapin_Pallidin PF14712.6 PIK52213.1 - 0.082 13.3 1.7 0.21 12.0 1.7 1.7 1 0 0 1 1 1 0 Snapin/Pallidin Hrs_helical PF12210.8 PIK52213.1 - 0.084 13.4 0.3 0.19 12.3 0.3 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Prominin PF05478.11 PIK52213.1 - 0.26 9.2 3.7 0.38 8.7 3.7 1.2 1 0 0 1 1 1 0 Prominin SR-25 PF10500.9 PIK52213.1 - 1.2 8.7 16.9 2.3 7.8 16.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FapA PF03961.13 PIK52213.1 - 2.1 6.9 5.4 2.6 6.5 4.6 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A SMC_N PF02463.19 PIK52214.1 - 2.4e-60 203.7 45.1 1.1e-32 113.2 18.4 2.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK52214.1 - 4.7e-27 94.6 0.1 1.8e-26 92.7 0.1 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 PIK52214.1 - 3.2e-12 46.9 1.0 1.1e-05 25.4 0.0 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 PIK52214.1 - 1.4e-11 45.3 9.2 1.4e-11 45.3 9.2 7.8 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 PIK52214.1 - 2.5e-07 30.7 74.3 0.00016 21.5 1.5 4.7 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 PIK52214.1 - 0.0002 21.0 0.0 0.00043 20.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 PIK52214.1 - 0.66 10.5 0.0 0.66 10.5 0.0 6.8 3 2 0 3 3 3 0 ABC transporter Ig_3 PF13927.6 PIK52215.1 - 1.5e-08 35.1 0.0 2.3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK52215.1 - 2e-08 34.2 0.0 2.8e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52215.1 - 8e-07 29.3 0.3 1.3e-06 28.6 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK52215.1 - 2.3e-06 27.7 1.0 0.006 16.7 0.6 2.2 1 1 1 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK52215.1 - 2.1e-05 24.6 0.1 3.9e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_4 PF16680.5 PIK52215.1 - 0.027 14.7 0.1 0.094 13.0 0.1 1.8 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 PIK52215.1 - 0.041 14.3 0.2 0.12 12.8 0.2 1.8 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Fibrinogen_C PF00147.18 PIK52216.1 - 1.5e-45 155.7 1.5 2.9e-45 154.8 1.5 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK52216.1 - 1.7e-05 24.9 9.8 1.7e-05 24.9 9.8 3.3 3 1 0 3 3 3 1 EGF domain CobS_N PF12556.8 PIK52216.1 - 0.6 9.9 8.4 76 3.1 0.1 4.3 4 0 0 4 4 4 0 Cobaltochelatase CobS subunit N terminal DUF2717 PF10911.8 PIK52217.1 - 0.017 14.8 0.4 46 3.8 0.0 4.8 3 3 2 5 5 5 0 Protein of unknown function (DUF2717) Fibrinogen_C PF00147.18 PIK52218.1 - 1.5e-61 208.0 6.0 2e-61 207.6 6.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain zf-C2H2 PF00096.26 PIK52219.1 - 3.4e-06 27.2 1.1 7.1e-06 26.2 1.1 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.7 PIK52219.1 - 0.00023 21.4 0.1 0.00048 20.4 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK52219.1 - 0.0003 21.0 0.4 0.00056 20.1 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK52219.1 - 0.00064 20.3 0.7 0.0016 19.1 0.7 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK52219.1 - 0.00067 19.6 0.1 0.0013 18.7 0.1 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger Nop14 PF04147.12 PIK52219.1 - 0.24 9.5 9.4 0.27 9.4 9.4 1.0 1 0 0 1 1 1 0 Nop14-like family zf-H2C2_2 PF13465.6 PIK52219.1 - 1.7 9.2 4.6 6.1 7.5 0.1 2.6 3 0 0 3 3 3 0 Zinc-finger double domain DNA_pol_phi PF04931.13 PIK52219.1 - 3.2 5.7 9.9 4.1 5.4 9.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Transposase_21 PF02992.14 PIK52220.1 - 0.066 12.5 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Transposase family tnp2 Fibrinogen_C PF00147.18 PIK52221.1 - 1.2e-44 152.8 0.6 1.3e-44 152.7 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4470 PF14737.6 PIK52222.1 - 7.6e-17 61.3 0.1 1.2e-16 60.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) PET122 PF05476.11 PIK52222.1 - 0.091 12.0 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 PET122 DUF4470 PF14737.6 PIK52223.1 - 1.1e-16 60.8 0.0 1.5e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) DUF4470 PF14737.6 PIK52224.1 - 1e-13 51.3 0.1 2.3e-13 50.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 PIK52224.1 - 2.9e-13 49.6 35.2 1e-09 38.3 14.5 2.6 2 0 0 2 2 2 2 MYND finger zf-Mss51 PF13824.6 PIK52224.1 - 2 8.5 18.9 0.043 13.9 3.6 2.6 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C6H2 PF15801.5 PIK52224.1 - 5.1 7.5 22.1 9.1 6.7 10.0 2.7 1 1 1 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding COLFI PF01410.18 PIK52225.1 - 1.9e-11 43.7 15.0 4.8e-06 26.1 0.9 4.2 4 1 0 4 4 4 3 Fibrillar collagen C-terminal domain SH3_4 PF06347.13 PIK52225.1 - 0.024 14.5 0.6 0.063 13.1 0.6 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Arteri_GP4 PF02497.15 PIK52226.1 - 0.087 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Arterivirus glycoprotein WSC PF01822.19 PIK52228.1 - 3.7e-06 27.0 5.9 3.7e-06 27.0 5.9 2.0 2 0 0 2 2 2 1 WSC domain WSC PF01822.19 PIK52229.1 - 2.1e-16 59.9 24.1 1e-11 44.8 8.4 3.1 3 0 0 3 3 3 2 WSC domain Pkinase PF00069.25 PIK52230.1 - 1.4e-18 67.3 0.1 1.7e-18 67.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52230.1 - 7.4e-06 25.4 0.0 8.5e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK52230.1 - 0.00069 19.0 0.1 0.0012 18.2 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK52230.1 - 0.0017 17.2 0.0 0.0022 16.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK52230.1 - 0.0056 16.6 0.0 0.0073 16.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK52230.1 - 0.019 14.5 0.3 0.077 12.6 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase WSC PF01822.19 PIK52231.1 - 1e-14 54.5 26.4 2.8e-10 40.2 5.0 3.0 3 0 0 3 3 3 2 WSC domain VWC PF00093.18 PIK52232.1 - 1.9e-06 28.1 15.7 1.9e-06 28.1 15.7 1.9 2 0 0 2 2 2 1 von Willebrand factor type C domain TILa PF12714.7 PIK52232.1 - 0.013 15.4 8.3 0.046 13.7 8.3 1.9 1 0 0 1 1 1 0 TILa domain zf-C4 PF00105.18 PIK52233.1 - 1.8e-28 98.8 18.8 3e-28 98.1 18.8 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK52234.1 - 1.5e-21 76.9 0.1 2.6e-21 76.1 0.1 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor OATP PF03137.20 PIK52235.1 - 2e-42 145.2 5.6 2.6e-42 144.9 5.6 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK52235.1 - 1.8e-06 28.0 12.0 1.8e-06 28.0 12.0 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK52235.1 - 4.5e-06 26.6 5.2 1.3e-05 25.1 5.2 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain UPF0542 PF15086.6 PIK52235.1 - 0.8 9.7 0.0 0.8 9.7 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 OATP PF03137.20 PIK52236.1 - 9.4e-93 311.3 4.5 1.1e-92 311.1 4.5 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK52236.1 - 5.5e-17 61.7 15.0 2.5e-12 46.4 13.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK52236.1 - 3.2e-07 30.4 9.4 7.1e-07 29.3 9.4 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK52236.1 - 2.9e-05 24.0 5.2 2.9e-05 24.0 5.2 1.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain DUF4386 PF14329.6 PIK52236.1 - 0.034 14.0 0.4 0.034 14.0 0.4 3.6 3 2 0 3 3 3 0 Domain of unknown function (DUF4386) OATP PF03137.20 PIK52237.1 - 1.6e-48 165.3 0.2 1.9e-48 165.1 0.2 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK52237.1 - 1.5e-10 40.5 2.5 8.4e-07 28.2 0.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily PGG PF13962.6 PIK52237.1 - 0.15 11.9 4.5 0.2 11.5 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function MFS_1_like PF12832.7 PIK52237.1 - 0.18 10.6 5.4 0.041 12.7 0.9 1.8 2 0 0 2 2 2 0 MFS_1 like family ATG22 PF11700.8 PIK52237.1 - 0.54 8.8 6.9 0.15 10.6 0.5 2.5 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like OATP PF03137.20 PIK52238.1 - 5.8e-63 213.0 12.2 8.2e-63 212.5 12.2 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK52238.1 - 8.4e-09 35.4 9.2 8.4e-09 35.4 9.2 2.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK52238.1 - 1.3e-05 25.1 5.3 3.6e-05 23.7 5.3 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF1096 PF06493.11 PIK52238.1 - 2.6 8.6 8.4 11 6.6 8.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1096) OATP PF03137.20 PIK52239.1 - 2.7e-36 125.0 3.1 3.3e-36 124.7 3.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK52239.1 - 1.8e-10 40.8 6.8 1.2e-09 38.1 7.1 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 PIK52239.1 - 1e-07 31.2 0.8 1.2e-07 31.0 0.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Kazal_1 PF00050.21 PIK52239.1 - 2.6e-07 30.5 8.1 5.4e-07 29.5 8.1 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF5360 PF17314.2 PIK52239.1 - 0.05 13.7 3.1 0.48 10.5 0.4 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5360) MscS_TM PF12794.7 PIK52239.1 - 0.1 11.5 0.4 0.13 11.1 0.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 RNA_pol_Rpb1_1 PF04997.12 PIK52240.1 - 2.4e-100 335.9 0.0 4.8e-100 334.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 PIK52240.1 - 5.3e-76 254.5 0.1 1.1e-75 253.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 PIK52240.1 - 1.5e-64 218.0 0.0 3.3e-64 216.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.14 PIK52240.1 - 1.8e-61 207.3 1.6 3.5e-61 206.4 1.6 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 PIK52240.1 - 1.3e-49 168.1 0.0 2.7e-49 167.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 PIK52240.1 - 5e-39 132.6 0.3 5.6e-38 129.2 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 PARG_cat PF05028.14 PIK52241.1 - 1e-73 248.5 0.1 7.6e-54 183.3 0.0 2.2 2 0 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) Regulator_TrmB PF11495.8 PIK52243.1 - 0.081 12.1 0.5 0.15 11.2 0.2 1.5 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB Ank_2 PF12796.7 PIK52244.1 - 4.3e-24 84.9 1.0 6.2e-11 42.7 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK52244.1 - 2.3e-20 72.7 0.1 4.8e-09 36.6 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK52244.1 - 9.4e-13 48.1 0.1 2.4e-11 43.7 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK52244.1 - 1.5e-11 43.4 0.1 0.0028 18.0 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 PIK52244.1 - 1.9e-09 37.5 0.2 0.066 13.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat DUF1843 PF08898.10 PIK52244.1 - 0.0063 17.0 1.6 0.24 11.9 0.0 3.2 4 0 0 4 4 3 1 Domain of unknown function (DUF1843) DUF1699 PF08004.11 PIK52244.1 - 0.02 14.6 0.0 0.058 13.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) V_ATPase_I PF01496.19 PIK52244.1 - 0.044 11.7 3.4 1.1 7.1 7.1 1.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family EPSP_synthase PF00275.20 PIK52244.1 - 0.052 12.2 0.9 4 6.0 0.1 2.4 2 1 1 3 3 3 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) GBP_C PF02841.14 PIK52244.1 - 0.067 12.6 7.6 0.12 11.8 7.6 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Exonuc_VII_L PF02601.15 PIK52244.1 - 0.099 12.2 4.2 0.13 11.8 4.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Alpha-E PF04168.12 PIK52244.1 - 0.19 11.5 4.0 0.21 11.3 3.1 1.5 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Macoilin PF09726.9 PIK52244.1 - 0.19 10.2 6.9 0.21 10.1 6.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF3450 PF11932.8 PIK52244.1 - 0.47 9.7 6.8 0.53 9.5 5.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ALMT PF11744.8 PIK52244.1 - 0.53 9.1 1.9 0.7 8.7 1.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter TIM21 PF08294.11 PIK52244.1 - 0.76 9.7 3.2 2.9 7.8 2.5 2.2 2 1 0 2 2 2 0 TIM21 Pox_A_type_inc PF04508.12 PIK52244.1 - 0.81 9.6 14.9 0.85 9.6 2.4 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Fmp27_WPPW PF10359.9 PIK52244.1 - 4.3 6.1 9.4 5.5 5.7 8.9 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Spc7 PF08317.11 PIK52244.1 - 4.6 6.0 11.2 6.6 5.5 11.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 PIK52244.1 - 4.6 7.4 17.0 4.6 7.5 15.4 1.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Syntaxin_2 PF14523.6 PIK52244.1 - 5.4 7.4 10.7 1.2e+02 3.1 0.9 3.0 2 1 1 3 3 3 0 Syntaxin-like protein CENP-K PF11802.8 PIK52244.1 - 7.8 6.0 12.4 4.7 6.7 9.3 1.8 1 1 1 2 2 2 0 Centromere-associated protein K Pkinase PF00069.25 PIK52245.1 - 4.7e-47 160.6 0.0 6.1e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52245.1 - 5.2e-20 71.8 0.0 6.5e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK52245.1 - 3.6e-08 33.1 0.0 4.7e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK52245.1 - 0.21 10.5 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain MFS_1 PF07690.16 PIK52246.1 - 5.7e-24 84.7 46.7 9.4e-12 44.5 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TAF6_C PF07571.13 PIK52246.1 - 0.13 12.6 0.0 0.53 10.7 0.0 2.0 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Pkinase PF00069.25 PIK52247.1 - 1e-38 133.2 0.0 1.3e-38 132.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52247.1 - 4.4e-31 108.1 0.0 6.4e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 PIK52247.1 - 0.016 14.8 0.0 0.016 14.8 0.0 1.5 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 PIK52247.1 - 0.042 12.6 0.3 0.071 11.9 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase APH_6_hur PF04655.14 PIK52247.1 - 0.042 13.2 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Myb_DNA-binding PF00249.31 PIK52248.1 - 1.7e-08 34.5 0.0 2.6e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK52248.1 - 0.00018 21.3 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 PIK52248.1 - 0.00028 21.1 0.1 0.00044 20.4 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain VWC PF00093.18 PIK52249.1 - 7.8e-09 35.7 12.6 1.1e-08 35.2 12.6 1.3 1 0 0 1 1 1 1 von Willebrand factor type C domain Amnionless PF14828.6 PIK52249.1 - 7.6e-05 21.7 6.7 0.00011 21.2 6.7 1.3 1 0 0 1 1 1 1 Amnionless CDC27 PF09507.10 PIK52250.1 - 8.6e-17 61.6 80.2 6.4e-16 58.8 80.2 1.9 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 SCHIP-1 PF10148.9 PIK52251.1 - 1.1e-56 192.1 7.0 1.1e-56 192.1 7.0 2.9 3 0 0 3 3 3 1 Schwannomin-interacting protein 1 FEZ PF07763.13 PIK52251.1 - 7.9e-06 25.8 3.2 2.9e-05 23.9 3.2 1.9 1 0 0 1 1 1 1 FEZ-like protein KCNQC3-Ank-G_bd PF11956.8 PIK52251.1 - 0.027 14.7 2.8 0.042 14.1 0.0 2.7 3 0 0 3 3 3 0 Ankyrin-G binding motif of KCNQ2-3 FUSC-like PF12805.7 PIK52251.1 - 0.44 9.6 3.7 0.76 8.8 3.7 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Voldacs PF03517.13 PIK52252.1 - 1.4e-28 99.7 0.2 2e-28 99.2 0.2 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling DUF4663 PF15668.5 PIK52254.1 - 0.19 10.8 4.5 0.24 10.4 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) LIN37 PF15306.6 PIK52254.1 - 0.53 10.5 5.8 0.87 9.8 5.8 1.3 1 0 0 1 1 1 0 LIN37 zf-CCHC PF00098.23 PIK52256.1 - 0.13 12.4 6.2 0.25 11.5 6.2 1.5 1 0 0 1 1 1 0 Zinc knuckle RIO1 PF01163.22 PIK52257.1 - 5.7e-48 163.0 0.1 9.2e-48 162.3 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK52257.1 - 7.9e-09 35.8 1.9 0.00034 20.6 1.6 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK52257.1 - 1.1e-06 28.1 0.3 3e-05 23.5 0.3 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Rio2_N PF09202.11 PIK52257.1 - 1.5e-05 25.1 0.0 4.2e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Rio2, N-terminal Seadorna_VP7 PF07387.11 PIK52257.1 - 0.039 13.0 0.1 0.055 12.5 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 PIK52257.1 - 0.041 13.3 1.0 0.17 11.2 1.0 2.0 1 1 0 1 1 1 0 Protein kinase domain Kinase-like PF14531.6 PIK52257.1 - 0.15 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Band_7_C PF16200.5 PIK52258.1 - 6.6e-25 86.9 3.1 9.9e-25 86.4 1.6 2.1 2 0 0 2 2 2 1 C-terminal region of band_7 Band_7 PF01145.25 PIK52258.1 - 3e-11 43.6 0.4 3e-11 43.6 0.4 2.5 3 0 0 3 3 3 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 PIK52258.1 - 0.0028 17.4 1.3 0.0062 16.3 0.2 1.9 2 0 0 2 2 2 1 SPFH domain-Band 7 family Abi_C PF14355.6 PIK52258.1 - 0.037 14.1 0.4 4.1 7.6 0.1 2.6 2 0 0 2 2 2 0 Abortive infection C-terminus Band_7 PF01145.25 PIK52259.1 - 1e-10 41.9 0.0 1.1e-10 41.8 0.0 1.0 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF1413 PF07205.11 PIK52260.1 - 0.009 16.0 0.8 0.02 14.9 0.3 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1413) TRIQK PF15168.6 PIK52260.1 - 1.4 8.9 4.3 1.9 8.4 4.3 1.2 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family NARP1 PF12569.8 PIK52260.1 - 1.4 7.7 10.4 1.7 7.5 10.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 tRNA-synt_2 PF00152.20 PIK52262.1 - 1.1e-101 340.0 0.2 2.1e-101 339.2 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 PIK52262.1 - 3.5e-05 23.7 0.0 7.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Sema PF01403.19 PIK52263.1 - 2.8e-49 168.1 1.1 5e-49 167.3 1.1 1.3 1 0 0 1 1 1 1 Sema domain RVT_1 PF00078.27 PIK52264.1 - 1e-15 57.9 0.1 1.5e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) C1_1 PF00130.22 PIK52267.1 - 1.6e-07 31.1 10.4 2.8e-07 30.3 10.4 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 PIK52267.1 - 0.19 11.7 9.1 0.38 10.7 9.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Ribosomal_L17 PF01196.19 PIK52268.1 - 0.18 12.7 0.1 0.39 11.7 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L17 DASH_Dam1 PF08653.10 PIK52268.1 - 2.1 8.2 5.4 1.2 9.0 0.2 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 Ribosomal_S10 PF00338.22 PIK52269.1 - 8.5e-16 58.0 0.0 1.3e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4448 PF14610.6 PIK52270.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Adeno_E3_CR2 PF02439.15 PIK52270.1 - 1.3 8.9 8.7 2.8 7.8 8.7 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ank_2 PF12796.7 PIK52271.1 - 3.8e-11 43.4 0.2 9.5e-11 42.1 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK52271.1 - 5.7e-09 36.1 0.3 4.1e-07 30.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK52271.1 - 2.5e-08 34.0 0.0 0.0047 17.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 PIK52271.1 - 2.2e-07 30.6 0.0 0.0047 17.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 PIK52271.1 - 7.2e-06 26.5 0.0 1.7e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Polyhedrin PF00738.18 PIK52271.1 - 5.5e-05 22.6 3.2 0.17 11.2 0.2 2.6 2 0 0 2 2 2 2 Polyhedrin UFD1 PF03152.14 PIK52271.1 - 0.0011 18.4 3.9 0.94 8.9 0.1 3.3 3 0 0 3 3 3 2 Ubiquitin fusion degradation protein UFD1 DUF4452 PF14618.6 PIK52271.1 - 0.084 12.7 6.8 3.5 7.4 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4452) PE PF00934.20 PIK52271.1 - 0.098 13.0 3.9 32 4.9 0.0 4.2 3 0 0 3 3 3 0 PE family Cas9_PI2 PF18070.1 PIK52271.1 - 1.8 9.4 8.2 19 6.0 0.5 3.5 3 0 0 3 3 3 0 CRISPR-Cas9 PI domain Ank_5 PF13857.6 PIK52272.1 - 4.9e-24 84.1 6.1 2.8e-08 33.9 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK52272.1 - 4.5e-23 81.6 2.1 4.1e-12 46.5 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK52272.1 - 1.6e-20 72.5 2.5 0.00043 20.6 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 PIK52272.1 - 1.4e-18 67.0 0.1 1e-08 35.6 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK52272.1 - 7.6e-16 56.6 0.2 0.00041 20.6 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat AAA_2 PF07724.14 PIK52273.1 - 1.7e-38 132.4 0.0 3.1e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 PIK52273.1 - 1.1e-13 51.1 0.1 2.4e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 PIK52273.1 - 4.3e-11 43.4 0.0 8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 PIK52273.1 - 3.2e-05 23.4 0.3 0.0063 15.9 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 PIK52273.1 - 8.7e-05 22.3 0.1 0.0012 18.6 0.1 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 PIK52273.1 - 0.00015 21.8 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK52273.1 - 0.0053 16.3 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 PIK52273.1 - 0.0088 15.8 0.0 0.028 14.2 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK52273.1 - 0.015 15.6 0.1 0.039 14.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 PIK52273.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 PIK52273.1 - 0.02 13.9 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 PIK52273.1 - 0.026 14.4 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 PIK52273.1 - 0.03 13.8 0.2 0.09 12.2 0.2 1.8 1 1 0 1 1 1 0 PhoH-like protein A2L_zn_ribbon PF08792.10 PIK52273.1 - 0.053 13.2 0.5 6.3 6.6 0.1 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain DEAD PF00270.29 PIK52273.1 - 0.056 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase MCM PF00493.23 PIK52273.1 - 0.067 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain TsaE PF02367.17 PIK52273.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 PIK52273.1 - 0.13 12.0 0.1 0.43 10.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain PDCD7 PF16021.5 PIK52274.1 - 2.7e-47 161.4 23.3 3.9e-47 160.9 23.3 1.2 1 0 0 1 1 1 1 Programmed cell death protein 7 LMBR1 PF04791.16 PIK52274.1 - 0.19 10.6 8.8 0.22 10.4 8.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Bestrophin PF01062.21 PIK52274.1 - 4.3 6.6 6.7 0.94 8.8 2.9 1.8 1 1 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel HSP70 PF00012.20 PIK52274.1 - 9.4 4.3 14.2 13 3.8 14.2 1.3 1 0 0 1 1 1 0 Hsp70 protein ANAPC4_WD40 PF12894.7 PIK52275.1 - 6.6e-08 32.7 0.1 0.075 13.3 0.0 5.0 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK52275.1 - 2.4e-06 28.2 7.1 0.042 14.7 0.9 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat WD40_like PF17005.5 PIK52275.1 - 9.5e-05 21.9 0.0 0.046 13.0 0.0 2.7 3 0 0 3 3 3 2 WD40-like domain Ank_4 PF13637.6 PIK52276.1 - 2.6e-29 101.2 2.6 5.7e-08 33.2 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK52276.1 - 1.5e-26 92.8 0.8 2.1e-14 53.9 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK52276.1 - 1.2e-16 59.1 0.2 9.2e-05 22.6 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK52276.1 - 1.5e-14 53.6 2.4 3.1e-05 24.2 0.1 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 PIK52276.1 - 5.7e-12 45.6 0.4 3.3e-06 27.3 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ribosomal_S6e PF01092.19 PIK52277.1 - 1e-60 203.2 0.0 2.2e-60 202.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Pkinase_Tyr PF07714.17 PIK52278.1 - 2e-12 46.9 0.0 2.5e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52278.1 - 3e-08 33.3 0.0 3.9e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 PIK52279.1 - 1.4e-19 70.1 1.1 2.5e-10 40.7 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK52279.1 - 6.6e-19 68.3 0.9 2.1e-08 34.6 0.8 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK52279.1 - 1.4e-18 65.0 1.5 0.00026 21.2 0.2 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 PIK52279.1 - 2.6e-15 56.1 0.9 1.2e-05 25.5 0.5 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK52279.1 - 5.1e-15 55.3 3.1 8.5e-08 32.3 0.6 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DUF2813 PF11398.8 PIK52279.1 - 0.063 12.5 0.0 0.096 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Lig_chan-Glu_bd PF10613.9 PIK52280.1 - 1.8e-18 66.8 0.0 2.9e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 PIK52280.1 - 3.5e-11 42.8 0.0 4.7e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Y2_Tnp PF04986.13 PIK52280.1 - 0.088 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative transposase Lig_chan PF00060.26 PIK52281.1 - 8.3e-54 181.5 0.1 1e-53 181.1 0.1 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 PIK52281.1 - 1.6e-07 31.0 0.0 2.2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Podoplanin PF05808.11 PIK52281.1 - 0.26 11.4 0.5 0.45 10.6 0.5 1.3 1 0 0 1 1 1 0 Podoplanin V_ATPase_I PF01496.19 PIK52282.1 - 0.36 8.7 7.2 0.46 8.4 7.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Het-C PF07217.11 PIK52282.1 - 0.43 9.1 5.8 0.5 8.8 5.8 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Exonuc_VII_L PF02601.15 PIK52282.1 - 1.4 8.4 11.7 1.6 8.3 11.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit HAUS-augmin3 PF14932.6 PIK52282.1 - 1.5 8.3 13.1 2 7.9 12.2 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Phage_GPO PF05929.11 PIK52282.1 - 6.6 6.3 10.1 14 5.2 10.0 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DivIC PF04977.15 PIK52283.1 - 0.01 15.6 2.9 0.015 15.0 2.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Speriolin_N PF15058.6 PIK52283.1 - 0.02 15.0 0.4 0.025 14.7 0.4 1.1 1 0 0 1 1 1 0 Speriolin N terminus AlkA_N PF06029.11 PIK52283.1 - 0.083 13.2 0.1 0.15 12.4 0.1 1.3 1 1 0 1 1 1 0 AlkA N-terminal domain TMF_DNA_bd PF12329.8 PIK52284.1 - 0.02 14.9 1.3 0.02 14.9 1.3 7.7 3 3 5 8 8 8 0 TATA element modulatory factor 1 DNA binding Sec20 PF03908.13 PIK52284.1 - 1.3 9.0 6.0 0.39 10.7 0.5 3.0 2 0 0 2 2 2 0 Sec20 Elongin_A PF06881.11 PIK52285.1 - 1.8e-16 60.5 0.2 1.8e-16 60.5 0.2 2.7 3 0 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Oxygenase-NA PF09859.9 PIK52286.1 - 0.08 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA p450 PF00067.22 PIK52287.1 - 3.7e-83 279.8 0.6 2.7e-53 181.4 0.1 2.3 2 0 0 2 2 2 2 Cytochrome P450 S-methyl_trans PF02574.16 PIK52287.1 - 2.5e-33 116.0 0.1 3.9e-33 115.4 0.1 1.2 1 0 0 1 1 1 1 Homocysteine S-methyltransferase TFR_dimer PF04253.15 PIK52288.1 - 8.2e-26 90.5 0.0 1.3e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 PIK52288.1 - 9.7e-19 67.8 0.0 1.9e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 PIK52288.1 - 1.7e-08 34.4 0.0 3.7e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 PIK52288.1 - 0.00069 19.4 0.0 0.00091 19.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 UPRTase PF14681.6 PIK52289.1 - 6.7e-38 130.2 0.0 4.7e-36 124.2 0.0 2.1 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Ribosomal_S4e PF00900.20 PIK52290.1 - 2.8e-36 123.3 0.4 4.5e-35 119.4 0.2 2.3 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 PIK52290.1 - 3.9e-26 90.4 0.0 7.6e-26 89.5 0.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 PIK52290.1 - 2.5e-21 75.5 6.6 5.3e-21 74.5 6.6 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 PIK52290.1 - 0.00031 20.6 0.0 0.0012 18.7 0.0 2.0 1 0 0 1 1 1 1 KOW motif BSD PF03909.17 PIK52291.1 - 5.4e-15 55.1 3.0 6e-15 55.0 0.8 2.2 2 0 0 2 2 2 1 BSD domain HECA PF15353.6 PIK52292.1 - 2.2e-45 153.1 6.5 4.1e-45 152.2 6.5 1.4 1 0 0 1 1 1 1 Headcase protein family homologue RRM_1 PF00076.22 PIK52293.1 - 2.4e-24 84.9 0.5 1.7e-16 59.8 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 PIK52293.1 - 2.8e-11 43.2 0.0 5.2e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RNA_bind PF08675.11 PIK52293.1 - 0.00029 20.8 0.0 0.16 12.0 0.0 3.6 3 1 1 4 4 4 2 RNA binding domain RRM_2 PF04059.12 PIK52293.1 - 0.012 15.8 0.1 0.33 11.2 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif 2 PWI PF01480.17 PIK52295.1 - 1.7e-08 34.6 0.6 2.9e-08 33.9 0.6 1.4 1 0 0 1 1 1 1 PWI domain PCM1_C PF15717.5 PIK52295.1 - 4.3 5.9 7.6 6.8 5.3 7.6 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus PWI PF01480.17 PIK52296.1 - 1.8e-13 50.6 0.2 2.7e-13 50.0 0.2 1.3 1 0 0 1 1 1 1 PWI domain cNMP_binding PF00027.29 PIK52297.1 - 7.6e-19 67.6 0.0 4.4e-13 49.1 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain DsbG_N PF18257.1 PIK52297.1 - 0.0021 18.1 0.4 0.0049 17.0 0.4 1.6 1 0 0 1 1 1 1 Disulfide isomerase DsbG N-terminal Ribosomal_L31e PF01198.19 PIK52298.1 - 9e-46 154.0 2.2 1.1e-45 153.7 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e ASC PF00858.24 PIK52299.1 - 1.4e-38 133.1 0.1 1.8e-38 132.7 0.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel COMM_domain PF07258.14 PIK52300.1 - 4.4e-15 55.6 0.0 7.6e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 COMM domain Glyco_transf_29 PF00777.18 PIK52301.1 - 1.8e-34 119.4 0.4 2.5e-34 118.9 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ribosomal_L21e PF01157.18 PIK52302.1 - 1.1e-45 153.5 5.8 1.1e-45 153.5 5.8 1.7 2 0 0 2 2 2 1 Ribosomal protein L21e PikAIV_N PF18605.1 PIK52302.1 - 0.34 10.5 1.4 0.57 9.8 1.4 1.3 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain UCH PF00443.29 PIK52303.1 - 6.2e-59 199.6 3.3 7.2e-59 199.4 3.3 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK52303.1 - 3.9e-28 99.0 6.4 6e-28 98.4 6.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 PIK52303.1 - 0.00057 19.4 13.4 0.02 14.4 11.7 2.7 2 1 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Lectin_C PF00059.21 PIK52304.1 - 3.9e-21 75.8 0.4 6.4e-17 62.3 0.5 2.1 2 0 0 2 2 2 2 Lectin C-type domain DHHC PF01529.20 PIK52305.1 - 9.6e-39 132.6 15.5 9.6e-39 132.6 15.5 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Spt4 PF06093.13 PIK52305.1 - 0.46 10.6 5.3 0.91 9.7 5.3 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger Cupin_8 PF13621.6 PIK52306.1 - 1.3e-61 208.6 0.3 2e-61 208.0 0.3 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK52306.1 - 0.0012 18.4 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 Cupin superfamily protein Ammonium_transp PF00909.21 PIK52307.1 - 2e-78 263.9 28.2 2.3e-78 263.7 28.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1691 PF07950.11 PIK52307.1 - 0.12 13.1 5.5 0.16 12.7 0.2 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF1691) DUF1129 PF06570.11 PIK52307.1 - 0.5 9.8 6.3 0.085 12.3 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) ZYG-11_interact PF05884.12 PIK52307.1 - 9.5 5.5 11.8 13 5.1 5.2 2.3 2 1 0 2 2 2 0 Interactor of ZYG-11 Ammonium_transp PF00909.21 PIK52308.1 - 9.6e-31 106.9 10.1 1.1e-30 106.7 10.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family HATPase_c_3 PF13589.6 PIK52309.1 - 0.0079 16.0 0.0 2.2 8.1 0.0 2.7 3 0 0 3 3 3 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase adh_short PF00106.25 PIK52311.1 - 2e-51 174.2 0.4 2.5e-51 173.9 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK52311.1 - 3.3e-35 121.8 0.2 5e-35 121.1 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK52311.1 - 4.7e-15 55.9 0.4 6.8e-15 55.4 0.4 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK52311.1 - 0.015 14.8 0.7 0.027 13.9 0.5 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ApbA PF02558.16 PIK52311.1 - 0.046 13.4 0.2 0.074 12.7 0.2 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.15 PIK52311.1 - 0.06 12.5 0.2 0.083 12.0 0.2 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 PIK52311.1 - 0.11 12.4 1.1 0.17 11.8 0.4 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YabA PF06156.13 PIK52312.1 - 0.04 14.6 0.7 0.086 13.5 0.7 1.6 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 PIK52312.1 - 0.066 13.7 0.8 0.14 12.6 0.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB ATG16 PF08614.11 PIK52312.1 - 0.068 13.4 3.3 0.099 12.9 3.3 1.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) BEN PF10523.9 PIK52312.1 - 0.087 13.1 0.0 0.31 11.3 0.0 2.0 2 0 0 2 2 2 0 BEN domain DUF2674 PF10879.8 PIK52312.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2674) DivIC PF04977.15 PIK52312.1 - 0.17 11.7 0.4 0.31 10.8 0.4 1.4 1 0 0 1 1 1 0 Septum formation initiator TSC22 PF01166.18 PIK52312.1 - 0.26 11.6 2.7 0.83 10.0 2.5 2.0 1 1 1 2 2 2 0 TSC-22/dip/bun family DTHCT PF08070.11 PIK52312.1 - 0.97 10.2 5.8 2 9.2 5.8 1.6 1 1 0 1 1 1 0 DTHCT (NUC029) region Transposase_21 PF02992.14 PIK52313.1 - 1.3e-05 24.6 0.0 2.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Transposase family tnp2 zinc_ribbon_5 PF13719.6 PIK52313.1 - 0.014 15.1 0.3 0.033 14.0 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Sulfatase PF00884.23 PIK52315.1 - 1.1e-65 222.1 0.1 2.3e-65 221.0 0.2 1.4 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 PIK52315.1 - 6.7e-05 23.6 0.1 0.00029 21.5 0.1 2.1 1 1 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK52315.1 - 0.00092 18.9 0.6 0.011 15.4 0.6 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4994 PF16385.5 PIK52315.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF229 PF02995.17 PIK52315.1 - 0.065 11.8 0.0 0.084 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) IBN_N PF03810.19 PIK52316.1 - 2.8e-13 49.6 4.5 8.7e-13 48.0 0.0 4.1 5 0 0 5 5 5 1 Importin-beta N-terminal domain Xpo1 PF08389.12 PIK52316.1 - 0.0026 17.8 10.3 0.017 15.2 0.1 4.9 5 2 1 6 6 6 1 Exportin 1-like protein TAF6_C PF07571.13 PIK52316.1 - 0.0056 17.0 0.9 23 5.4 0.0 5.1 4 2 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain TetR_C_10 PF16295.5 PIK52316.1 - 0.064 13.5 0.4 3.5 7.9 0.2 3.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RTP1_C1 PF10363.9 PIK52316.1 - 0.074 13.2 6.2 0.098 12.8 0.3 4.1 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2457 PF10446.9 PIK52316.1 - 0.3 10.2 17.8 0.44 9.6 17.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 PIK52316.1 - 2 7.6 11.3 3.4 6.9 11.3 1.3 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 PIK52316.1 - 7.2 5.9 13.1 11 5.4 13.1 1.2 1 0 0 1 1 1 0 SDA1 Thioredoxin PF00085.20 PIK52317.1 - 2.9e-08 33.6 0.1 6.7e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 PIK52317.1 - 6.3e-05 22.1 0.4 7.8e-05 21.8 0.4 1.1 1 0 0 1 1 1 1 Phosducin DIRP PF06584.13 PIK52318.1 - 1.6e-42 143.9 0.6 3.8e-42 142.8 0.6 1.7 1 0 0 1 1 1 1 DIRP 7tm_1 PF00001.21 PIK52319.1 - 6.4e-26 91.2 21.3 9.2e-26 90.7 21.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DDE_Tnp_IS1595 PF12762.7 PIK52320.1 - 6.5e-22 78.2 0.0 8.4e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Adaptin_N PF01602.20 PIK52321.1 - 9.7e-170 565.6 9.7 1.2e-169 565.3 9.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3B1_C PF14796.6 PIK52321.1 - 6.6e-47 159.5 0.5 1.5e-46 158.3 0.5 1.7 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Cnd1 PF12717.7 PIK52321.1 - 2.4e-22 79.7 8.7 1.4e-19 70.7 0.5 3.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK52321.1 - 2.8e-08 34.0 0.2 0.00056 20.2 0.0 4.5 4 2 3 7 7 7 4 HEAT repeats HEAT PF02985.22 PIK52321.1 - 7.4e-07 28.9 0.1 0.75 10.2 0.0 6.2 6 1 1 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 PIK52321.1 - 0.0091 16.5 1.4 2.8 8.5 0.0 4.8 4 2 3 7 7 7 1 HEAT-like repeat Tautomerase PF01361.21 PIK52321.1 - 0.015 15.2 0.2 0.24 11.3 0.0 2.6 2 0 0 2 2 2 0 Tautomerase enzyme DUF1186 PF06685.11 PIK52321.1 - 0.038 13.4 0.2 0.095 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Mem_trans PF03547.18 PIK52321.1 - 0.15 10.4 3.3 0.22 9.9 2.1 1.8 2 0 0 2 2 2 0 Membrane transport protein CLASP_N PF12348.8 PIK52321.1 - 0.37 10.3 2.2 11 5.4 0.1 3.2 2 1 0 2 2 2 0 CLASP N terminal Apt1 PF10351.9 PIK52321.1 - 1.9 7.2 19.4 3.6 6.3 19.4 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 PIK52321.1 - 2.2 6.8 15.6 3.3 6.2 15.6 1.2 1 0 0 1 1 1 0 Macoilin family BUD22 PF09073.10 PIK52321.1 - 6.3 6.0 55.3 0.52 9.6 48.3 2.1 2 0 0 2 2 2 0 BUD22 LAP1C PF05609.12 PIK52321.1 - 7.6 5.5 22.4 16 4.4 22.4 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SCAMP PF04144.13 PIK52322.1 - 8.2e-57 192.3 18.0 1e-56 192.0 18.0 1.1 1 0 0 1 1 1 1 SCAMP family Aminotran_1_2 PF00155.21 PIK52322.1 - 0.018 14.2 1.5 0.027 13.6 0.3 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II CopD PF05425.13 PIK52322.1 - 0.032 14.6 3.1 0.33 11.4 1.2 2.5 2 0 0 2 2 2 0 Copper resistance protein D Shisa PF13908.6 PIK52322.1 - 4 7.6 10.3 1.5 9.1 0.5 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator RVT_1 PF00078.27 PIK52324.1 - 1.7e-14 53.9 0.0 2.3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2HC_2 PF13913.6 PIK52325.1 - 2.9e-62 205.6 42.0 7.2e-11 41.7 2.1 7.3 7 0 0 7 7 7 7 zinc-finger of a C2HC-type Rad50_zn_hook PF04423.14 PIK52325.1 - 6.2e-10 38.8 2.9 1.5 8.8 0.0 5.8 6 0 0 6 6 6 3 Rad50 zinc hook motif zf-HC5HC2H PF13771.6 PIK52325.1 - 9.5e-05 22.6 7.1 0.17 12.2 0.2 3.9 3 1 0 3 3 3 2 PHD-like zinc-binding domain DUF2318 PF10080.9 PIK52325.1 - 0.00012 22.2 14.3 3.5 7.8 0.1 6.8 6 1 1 7 7 7 1 Predicted membrane protein (DUF2318) zf-C2H2 PF00096.26 PIK52325.1 - 0.00031 21.0 24.4 3 8.5 0.1 8.3 7 1 1 8 8 8 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52325.1 - 0.00046 20.8 32.2 3.9 8.6 0.1 7.7 7 0 0 7 7 7 1 C2H2-type zinc finger zf-CpG_bind_C PF12269.8 PIK52325.1 - 0.0028 17.5 10.3 1.9 8.2 0.2 4.8 3 1 2 5 5 5 1 CpG binding protein zinc finger C terminal domain zf-RING_7 PF02591.15 PIK52325.1 - 0.013 15.7 1.0 3.3 8.0 0.0 3.8 3 0 0 3 3 3 0 C4-type zinc ribbon domain DUF4633 PF15464.6 PIK52325.1 - 0.03 14.5 0.4 0.069 13.3 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) zf-C2H2_11 PF16622.5 PIK52325.1 - 0.04 13.7 11.3 4.5 7.1 0.0 6.1 5 0 0 5 5 5 0 zinc-finger C2H2-type c-SKI_SMAD_bind PF08782.10 PIK52325.1 - 0.083 13.1 18.9 3.1 8.1 0.0 6.2 6 1 1 7 7 7 0 c-SKI Smad4 binding domain Jas PF16135.5 PIK52325.1 - 0.13 12.4 0.9 2.8 8.2 0.0 3.2 3 0 0 3 3 3 0 TPL-binding domain in jasmonate signalling DUF3762 PF12591.8 PIK52325.1 - 0.15 12.3 4.2 13 6.1 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3762) zf_UBZ PF18439.1 PIK52325.1 - 0.29 10.8 12.9 21 4.8 0.1 5.8 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Sgf11 PF08209.11 PIK52325.1 - 0.32 10.6 16.4 10 5.8 0.0 6.1 6 0 0 6 6 6 0 Sgf11 (transcriptional regulation protein) zf-BED PF02892.15 PIK52325.1 - 0.42 10.7 11.9 29 4.8 0.0 5.0 5 0 0 5 5 4 0 BED zinc finger zf-HC5HC2H_2 PF13832.6 PIK52325.1 - 0.46 10.7 5.3 4.2 7.6 0.5 3.2 3 0 0 3 3 3 0 PHD-zinc-finger like domain FYVE PF01363.21 PIK52325.1 - 0.85 9.8 0.0 0.85 9.8 0.0 6.2 5 2 1 6 6 6 0 FYVE zinc finger HNH_5 PF14279.6 PIK52325.1 - 1.5 8.7 12.8 19 5.2 0.1 4.9 5 0 0 5 5 5 0 HNH endonuclease Ribosomal_L32p PF01783.23 PIK52325.1 - 1.8 8.9 14.2 4.3 7.7 0.1 5.0 5 0 0 5 5 4 0 Ribosomal L32p protein family zinc_ribbon_4 PF13717.6 PIK52325.1 - 2.5 8.1 13.3 1e+02 2.9 0.0 6.7 7 0 0 7 7 7 0 zinc-ribbon domain Herpes_BLRF2 PF05812.12 PIK52325.1 - 5.6 7.1 6.9 15 5.8 0.0 3.2 4 0 0 4 4 3 0 Herpesvirus BLRF2 protein DUF3039 PF11238.8 PIK52325.1 - 6 6.7 6.7 6.2 6.7 0.2 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3039) GRAM PF02893.20 PIK52326.1 - 1.9e-20 72.9 1.6 3.5e-20 72.0 0.3 2.2 3 0 0 3 3 3 1 GRAM domain CTP_transf_1 PF01148.20 PIK52326.1 - 0.004 17.0 0.7 0.54 10.0 0.1 2.9 3 0 0 3 3 3 1 Cytidylyltransferase family TssO PF17561.2 PIK52326.1 - 0.07 13.2 5.3 0.14 12.2 1.4 2.6 3 0 0 3 3 3 0 Type VI secretion system, TssO AI-2E_transport PF01594.16 PIK52326.1 - 0.11 11.6 1.5 0.16 11.1 1.5 1.2 1 0 0 1 1 1 0 AI-2E family transporter rve PF00665.26 PIK52328.1 - 5.7e-26 91.1 0.0 1.1e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52328.1 - 2.9e-05 23.7 0.0 5.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52328.1 - 0.00012 22.1 0.9 0.00026 21.0 0.9 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 PIK52328.1 - 0.00017 21.9 0.0 0.00025 21.3 0.0 1.3 1 0 0 1 1 1 1 DDE domain Ras PF00071.22 PIK52329.1 - 2.5e-17 62.9 0.4 3.4e-17 62.5 0.4 1.1 1 0 0 1 1 1 1 Ras family Methyltransf_22 PF13383.6 PIK52329.1 - 2.6e-05 23.9 0.3 8.3e-05 22.3 0.3 1.7 1 1 1 2 2 2 1 Methyltransferase domain Arf PF00025.21 PIK52329.1 - 0.013 15.0 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF1203 PF06718.11 PIK52329.1 - 0.042 14.1 0.6 0.1 12.9 0.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1203) UTP15_C PF09384.10 PIK52330.1 - 3.4e-42 143.6 0.3 5.3e-42 143.0 0.3 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 PIK52330.1 - 8.3e-10 39.1 2.6 0.77 10.7 0.0 6.1 5 1 0 5 5 5 3 WD domain, G-beta repeat Methyltransf_32 PF13679.6 PIK52331.1 - 6e-28 97.8 2.2 1.1e-14 54.7 0.1 2.6 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_2 PF00891.18 PIK52331.1 - 0.039 13.2 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Perilipin PF03036.16 PIK52332.1 - 3.5e-67 227.1 18.9 5.7e-43 147.4 12.1 2.0 1 1 1 2 2 2 2 Perilipin family DUF4820 PF16091.5 PIK52332.1 - 0.0062 15.9 0.1 0.0062 15.9 0.1 2.4 1 1 0 2 2 2 1 Domain of unknown function (DUF4820) Ig_3 PF13927.6 PIK52333.1 - 5e-12 46.3 1.5 2.6e-05 24.7 0.1 3.3 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK52333.1 - 9e-10 38.7 0.2 3.1e-09 37.0 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK52333.1 - 4.4e-07 30.0 2.8 0.0011 19.1 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK52333.1 - 1.2e-06 28.8 2.9 0.62 10.4 0.3 3.6 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK52333.1 - 1.6e-06 28.0 0.3 0.001 19.1 0.0 3.1 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_6 PF18452.1 PIK52333.1 - 0.00012 21.6 0.0 0.0029 17.2 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK52334.1 - 0.012 16.2 0.0 0.023 15.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 PIK52334.1 - 0.012 15.9 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Cation_ATPase_C PF00689.21 PIK52334.1 - 0.066 12.9 0.4 0.095 12.4 0.4 1.2 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Pkinase_Tyr PF07714.17 PIK52335.1 - 1.2e-30 106.7 0.0 1.9e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52335.1 - 1.3e-15 57.5 0.0 2.5e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK52335.1 - 1.5e-09 38.4 6.2 9.9e-05 22.9 0.4 3.6 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK52335.1 - 1.2e-08 35.1 1.0 3.4e-08 33.6 0.4 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK52335.1 - 3.1e-08 33.7 1.3 3.3e-05 24.0 0.8 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK52335.1 - 5e-07 29.7 0.4 0.0054 16.8 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52335.1 - 1.5e-05 25.2 5.0 0.0085 16.4 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52335.1 - 0.001 19.1 0.4 0.0045 17.0 0.4 2.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Imm6 PF14434.6 PIK52335.1 - 0.0054 16.7 0.2 0.024 14.6 0.0 2.2 2 0 0 2 2 2 1 Immunity protein Imm6 Vps26 PF03643.15 PIK52336.1 - 7.8e-58 195.7 0.8 9.4e-58 195.4 0.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 PIK52336.1 - 6.5e-09 36.0 0.4 2e-08 34.4 0.1 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain AvrM-A PF18241.1 PIK52336.1 - 0.079 13.4 0.3 0.12 12.8 0.3 1.2 1 0 0 1 1 1 0 Flax-rust effector AvrM-A CS PF04969.16 PIK52336.1 - 1.4 10.0 4.9 1.8 9.7 1.4 2.7 3 1 0 3 3 3 0 CS domain PRA1 PF03208.19 PIK52337.1 - 2.6e-37 127.6 3.7 3.4e-37 127.3 3.7 1.1 1 0 0 1 1 1 1 PRA1 family protein FA_desaturase PF00487.24 PIK52337.1 - 2.7 7.8 8.8 1.7 8.4 1.7 1.9 1 1 1 2 2 2 0 Fatty acid desaturase YL1_C PF08265.11 PIK52338.1 - 2.8e-06 27.0 7.2 1 9.2 0.2 4.7 3 0 0 3 3 3 3 YL1 nuclear protein C-terminal domain Propeptide_C25 PF08126.11 PIK52339.1 - 9e-09 34.7 15.6 1.7 7.7 0.0 8.1 7 2 1 8 8 8 4 Propeptide_C25 CX9C PF16860.5 PIK52339.1 - 2.8e-05 24.0 4.5 69 3.6 0.1 7.5 6 0 0 6 6 6 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Ferric_reduct PF01794.19 PIK52339.1 - 0.00037 20.6 0.0 2.3e+02 1.9 0.0 6.5 8 0 0 8 8 8 0 Ferric reductase like transmembrane component FPV060 PF17614.2 PIK52339.1 - 0.00056 19.4 16.4 33 3.8 0.3 8.0 6 1 1 8 8 8 1 Viral CC-type chemokine REC104 PF17378.2 PIK52339.1 - 0.015 15.1 34.3 6.7 6.5 0.1 7.7 8 0 0 8 8 8 0 Meiotic recombination protein REC104 Rieske_3 PF18465.1 PIK52340.1 - 0.025 14.8 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Rieske 3Fe-4S Ig_3 PF13927.6 PIK52341.1 - 6.7e-41 138.8 1.1 6.3e-18 65.2 0.2 3.1 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK52341.1 - 6.3e-40 135.2 0.0 4.7e-18 65.0 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52341.1 - 6.8e-31 106.5 0.0 6.1e-11 42.5 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK52341.1 - 2.8e-30 104.3 0.0 1.3e-15 57.3 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK52341.1 - 2.4e-13 50.2 0.2 0.0058 16.8 0.0 5.0 2 2 2 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK52341.1 - 3.4e-12 46.2 1.0 0.00031 20.8 0.2 3.3 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK52341.1 - 2.2e-06 28.0 0.0 0.0085 16.5 0.0 2.8 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK52341.1 - 8.5e-06 25.9 0.0 0.086 13.1 0.0 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 PIK52341.1 - 0.00012 21.6 0.0 0.12 12.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.21 PIK52342.1 - 1.2e-37 128.1 5.7 9e-10 38.8 0.1 4.9 5 0 0 5 5 5 4 Fibronectin type III domain Ig_3 PF13927.6 PIK52342.1 - 2.9e-12 47.0 0.0 1.2e-11 45.1 0.0 2.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK52342.1 - 1.6e-11 44.1 0.1 5e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52342.1 - 7.3e-08 32.6 0.0 1.7e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK52342.1 - 7.8e-08 32.4 0.0 7.8e-08 32.4 0.0 2.2 2 0 0 2 2 1 1 Immunoglobulin domain Interfer-bind PF09294.10 PIK52342.1 - 5.4e-07 29.9 0.0 0.96 9.8 0.0 4.0 3 0 0 3 3 3 3 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.17 PIK52342.1 - 0.0022 18.1 0.9 0.0055 16.9 0.1 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK52342.1 - 0.0042 16.6 0.0 0.0078 15.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK52342.1 - 0.0055 17.3 2.8 0.69 10.5 0.1 4.5 4 1 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain EphA2_TM PF14575.6 PIK52342.1 - 0.0094 16.8 0.0 0.035 15.0 0.0 2.0 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain fn3_4 PF16794.5 PIK52342.1 - 0.036 14.0 0.0 0.32 10.9 0.0 2.5 3 0 0 3 3 3 0 Fibronectin-III type domain BatD PF13584.6 PIK52342.1 - 0.12 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance BEN PF10523.9 PIK52344.1 - 1.6e-09 37.8 0.2 2.4e-09 37.3 0.2 1.3 1 0 0 1 1 1 1 BEN domain RHH_6 PF16762.5 PIK52344.1 - 0.14 12.8 0.0 2.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix domain MID_MedPIWI PF18296.1 PIK52345.1 - 0.015 15.1 2.0 0.02 14.7 2.0 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Cytochrom_C_2 PF01322.20 PIK52345.1 - 0.29 12.0 0.9 0.81 10.6 0.4 1.9 2 0 0 2 2 2 0 Cytochrome C' Transposase_21 PF02992.14 PIK52346.1 - 7.8e-09 35.1 0.2 7.8e-09 35.1 0.2 1.6 2 0 0 2 2 2 1 Transposase family tnp2 DUF1258 PF06869.12 PIK52346.1 - 3.3e-05 23.5 0.3 5.5e-05 22.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1258) zf-C3HC4 PF00097.25 PIK52346.1 - 2.5 8.0 8.8 0.43 10.5 3.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Shisa PF13908.6 PIK52347.1 - 0.018 15.3 0.1 0.028 14.7 0.1 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator UCH PF00443.29 PIK52348.1 - 6.2e-07 29.2 0.7 8.4e-07 28.7 0.7 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RnlB_antitoxin PF15933.5 PIK52351.1 - 0.092 13.1 0.0 19 5.6 0.0 2.5 2 0 0 2 2 2 0 Antitoxin to bacterial toxin RNase LS or RnlA Rad60-SLD PF11976.8 PIK52352.1 - 0.039 13.8 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like rve PF00665.26 PIK52353.1 - 4.4e-06 26.9 0.0 1.1e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain BEN PF10523.9 PIK52354.1 - 2.8e-10 40.3 0.0 4.3e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 BEN domain DUF3558 PF12079.8 PIK52354.1 - 1.5 8.8 7.7 2.2 8.3 6.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3558) SR-25 PF10500.9 PIK52354.1 - 2 7.9 10.2 3.1 7.3 10.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NosL PF05573.12 PIK52355.1 - 3.4e-05 24.2 18.8 1.2e+02 3.0 0.0 11.4 12 0 0 12 12 12 1 NosL EGF_CA PF07645.15 PIK52356.1 - 9.9e-30 102.5 68.9 3.7e-08 33.4 10.2 4.1 4 0 0 4 4 4 4 Calcium-binding EGF domain EGF PF00008.27 PIK52356.1 - 1.9e-22 79.2 55.6 1e-07 32.1 5.1 4.5 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK52356.1 - 3.9e-10 40.0 62.6 0.00086 19.8 4.7 5.3 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_3 PF12947.7 PIK52356.1 - 1.3e-09 38.1 43.6 0.0033 17.6 4.1 5.0 3 2 1 4 4 4 4 EGF domain EGF_2 PF07974.13 PIK52356.1 - 4.4e-08 33.4 69.0 0.086 13.2 12.8 4.4 3 1 1 4 4 4 4 EGF-like domain FXa_inhibition PF14670.6 PIK52356.1 - 4.2e-07 30.1 44.5 0.06 13.6 7.0 4.5 1 1 3 4 4 4 4 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK52356.1 - 1.9 8.6 60.2 1.4 9.0 7.4 4.2 4 0 0 4 4 4 0 MSP1 EGF domain 1 53-BP1_Tudor PF09038.10 PIK52356.1 - 3.3 7.7 5.4 1 9.3 0.5 2.1 1 1 2 3 3 3 0 Tumour suppressor p53-binding protein-1 Tudor NosL PF05573.12 PIK52357.1 - 0.00028 21.2 6.9 1.8e+02 2.4 0.0 7.1 7 0 0 7 7 7 0 NosL NosL PF05573.12 PIK52358.1 - 0.00093 19.6 3.8 1.1e+02 3.2 0.0 5.2 5 0 0 5 5 5 0 NosL YwqJ-deaminase PF14431.6 PIK52358.1 - 0.0043 17.2 5.0 1 9.5 0.0 3.7 4 0 0 4 4 4 2 YwqJ-like deaminase DUF4586 PF15239.6 PIK52359.1 - 7.2e-05 23.1 7.0 2.5 8.2 0.1 3.8 3 1 0 4 4 4 3 Domain of unknown function (DUF4586) YwqJ-deaminase PF14431.6 PIK52359.1 - 0.011 15.9 0.2 1.8 8.7 0.0 2.8 2 0 0 2 2 2 0 YwqJ-like deaminase Birna_VP5 PF03042.14 PIK52359.1 - 0.046 13.7 2.6 47 4.0 0.0 3.4 3 0 0 3 3 3 0 Birnavirus VP5 protein NosL PF05573.12 PIK52359.1 - 0.055 13.8 0.8 87 3.5 0.0 3.4 3 0 0 3 3 3 0 NosL CutC PF03932.14 PIK52359.1 - 0.13 11.7 2.9 4.9 6.6 0.0 3.0 4 0 0 4 4 4 0 CutC family YwqJ-deaminase PF14431.6 PIK52360.1 - 0.0006 20.0 0.7 2.7 8.2 0.1 5.2 2 0 0 2 2 2 2 YwqJ-like deaminase EGF_3 PF12947.7 PIK52360.1 - 0.45 10.8 15.0 0.31 11.3 3.9 2.5 2 0 0 2 2 2 0 EGF domain DUF4808 PF16066.5 PIK52361.1 - 3.1e-05 24.5 0.0 6.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) fn3 PF00041.21 PIK52361.1 - 0.014 15.7 0.1 0.034 14.5 0.1 1.6 1 0 0 1 1 1 0 Fibronectin type III domain HLH PF00010.26 PIK52362.1 - 7.3e-13 48.3 0.1 1.7e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CCDC106 PF15794.5 PIK52362.1 - 0.018 14.7 0.7 0.018 14.7 0.7 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 KASH_CCD PF14662.6 PIK52362.1 - 0.032 14.1 5.8 0.059 13.2 5.7 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.9 PIK52362.1 - 0.21 10.7 6.7 0.51 9.4 6.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_S2 PF00318.20 PIK52362.1 - 0.31 10.2 1.7 0.32 10.2 0.2 1.6 1 1 1 2 2 2 0 Ribosomal protein S2 Prefoldin_2 PF01920.20 PIK52362.1 - 0.35 10.8 4.8 0.68 9.9 4.8 1.6 1 1 0 1 1 1 0 Prefoldin subunit Peptidase_A17 PF05380.13 PIK52363.1 - 1.9e-40 138.5 1.1 2.6e-40 138.1 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK52364.1 - 1.2e-07 31.8 0.8 2.1e-07 31.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK52364.1 - 0.22 12.1 3.0 0.31 11.6 0.1 2.5 3 0 0 3 3 3 0 Tis11B like protein, N terminus NUDE_C PF04880.13 PIK52364.1 - 1.2 9.6 8.6 0.58 10.6 5.3 2.2 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region ANAPC4_WD40 PF12894.7 PIK52366.1 - 0.00047 20.4 0.5 20 5.6 0.0 5.0 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PAN_3 PF08277.12 PIK52366.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 PAN-like domain ADP_ribosyl_GH PF03747.14 PIK52367.1 - 4.5e-30 105.4 0.0 6.7e-30 104.8 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Ig_3 PF13927.6 PIK52368.1 - 3.5e-16 59.6 0.4 5.6e-16 58.9 0.4 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK52368.1 - 3.8e-14 52.5 0.0 6.4e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52368.1 - 6.5e-11 42.4 0.1 1.4e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Kazal_1 PF00050.21 PIK52368.1 - 6.5e-08 32.5 1.7 6.5e-08 32.5 1.7 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK52368.1 - 6.6e-08 32.6 1.4 6.6e-08 32.6 1.4 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain V-set PF07686.17 PIK52368.1 - 4.7e-07 29.9 0.0 8.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK52368.1 - 6.8e-06 26.2 0.4 4.8e-05 23.5 0.4 2.1 1 1 0 1 1 1 1 Immunoglobulin domain IGFBP PF00219.18 PIK52368.1 - 0.0026 18.4 14.6 0.0026 18.4 14.6 2.8 2 1 0 2 2 2 1 Insulin-like growth factor binding protein C2-set_2 PF08205.12 PIK52368.1 - 0.052 13.6 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain EamA PF00892.20 PIK52370.1 - 1.4e-18 67.4 35.5 6.8e-10 39.2 11.5 2.0 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 PIK52370.1 - 0.034 13.3 13.1 0.046 12.9 13.1 1.2 1 0 0 1 1 1 0 Nucleotide-sugar transporter H_PPase PF03030.16 PIK52370.1 - 0.039 12.6 8.8 0.041 12.5 8.0 1.4 1 1 0 1 1 1 0 Inorganic H+ pyrophosphatase TPT PF03151.16 PIK52370.1 - 2.5 7.4 20.1 0.29 10.4 11.0 2.1 1 1 1 2 2 2 0 Triose-phosphate Transporter family PHO4 PF01384.20 PIK52370.1 - 7 5.6 14.6 0.22 10.5 2.0 2.2 1 1 0 2 2 2 0 Phosphate transporter family Anillin PF08174.11 PIK52371.1 - 7.2e-31 107.5 0.1 9.8e-31 107.1 0.1 1.2 1 0 0 1 1 1 1 Cell division protein anillin DUF716 PF04819.12 PIK52373.1 - 2.5e-28 98.5 5.3 4.6e-28 97.6 5.3 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF716) DUF1240 PF06836.12 PIK52373.1 - 0.22 12.1 2.0 22 5.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) Ephrin_rec_like PF07699.13 PIK52374.1 - 1.4e-08 34.3 24.8 1e-05 25.2 5.5 4.0 1 1 2 3 3 3 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK52374.1 - 0.00037 20.4 15.7 0.029 14.3 1.1 3.7 3 0 0 3 3 3 2 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 PIK52375.1 - 6.9e-08 32.1 26.8 0.00012 21.7 7.2 4.0 1 1 3 4 4 4 4 Putative ephrin-receptor like NCD3G PF07562.14 PIK52375.1 - 0.0031 17.4 17.3 0.099 12.6 0.9 3.6 2 1 0 3 3 3 2 Nine Cysteines Domain of family 3 GPCR TRP PF06011.12 PIK52376.1 - 1.4e-06 27.3 8.9 2e-06 26.8 8.9 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF5379 PF17350.2 PIK52377.1 - 0.047 14.0 0.0 0.071 13.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5379) TraL PF07178.11 PIK52378.1 - 0.022 15.2 1.6 8.3 6.9 0.0 3.1 3 0 0 3 3 3 0 TraL protein Ephrin_rec_like PF07699.13 PIK52378.1 - 0.037 13.8 35.3 0.063 13.0 6.7 4.8 2 2 2 4 4 4 0 Putative ephrin-receptor like Chromo_shadow PF01393.19 PIK52379.1 - 8.9e-28 96.2 0.0 1.9e-27 95.1 0.0 1.6 1 0 0 1 1 1 1 Chromo shadow domain Chromo PF00385.24 PIK52379.1 - 3e-08 33.5 0.3 0.00012 21.9 0.4 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Transposase_21 PF02992.14 PIK52380.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Transposase family tnp2 rve PF00665.26 PIK52383.1 - 3.4e-17 62.7 0.3 6.4e-17 61.8 0.3 1.4 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK52384.1 - 2.6e-10 40.2 0.1 6.9e-10 38.9 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK52385.1 - 1.4e-28 98.8 0.0 2.3e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52385.1 - 2.9e-20 72.7 0.1 8.1e-20 71.3 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK52385.1 - 3.2e-15 56.3 0.0 5e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Flu_PB1 PF00602.17 PIK52385.1 - 0.094 10.8 0.0 0.12 10.4 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 RT_RNaseH_2 PF17919.1 PIK52386.1 - 1.4e-36 124.5 0.0 3.3e-36 123.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52386.1 - 5.7e-35 119.8 0.0 1.6e-33 115.2 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK52386.1 - 2.3e-21 76.2 0.0 3.5e-20 72.4 0.0 2.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52386.1 - 8.3e-20 70.7 1.1 2e-19 69.5 1.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK52386.1 - 0.0082 16.3 0.6 0.022 15.0 0.6 1.8 1 0 0 1 1 1 1 H2C2 zinc finger 2_5_RNA_ligase2 PF13563.6 PIK52386.1 - 0.021 14.8 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK52386.1 - 0.075 12.8 0.1 0.41 10.5 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain MLVIN_C PF18697.1 PIK52386.1 - 0.097 12.8 0.1 0.28 11.3 0.1 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RRM_1 PF00076.22 PIK52387.1 - 7.8e-46 153.8 0.0 6.9e-20 70.7 0.0 3.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK52387.1 - 0.0013 18.8 0.3 1 9.5 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 PIK52387.1 - 0.0078 16.2 0.2 0.14 12.2 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 PIK52387.1 - 0.009 15.9 0.0 0.52 10.2 0.0 3.2 3 1 0 3 3 3 1 Occluded RNA-recognition motif CRM1_C PF08767.11 PIK52388.1 - 0.028 13.6 0.5 0.19 10.9 0.1 2.2 2 0 0 2 2 2 0 CRM1 C terminal IBN_N PF03810.19 PIK52389.1 - 3.1e-08 33.4 1.3 1.8e-07 31.0 0.0 3.0 4 0 0 4 4 4 1 Importin-beta N-terminal domain Lipase PF00151.19 PIK52390.1 - 7e-78 262.3 0.5 1.1e-77 261.7 0.5 1.3 1 1 0 1 1 1 1 Lipase DUF900 PF05990.12 PIK52390.1 - 0.012 15.1 0.2 0.017 14.6 0.2 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 PIK52390.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 PIK52390.1 - 0.093 12.4 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DM13 PF10517.9 PIK52391.1 - 5.2e-49 165.2 0.0 3.4e-27 95.1 0.0 2.7 3 0 0 3 3 3 2 Electron transfer DM13 DOMON PF03351.17 PIK52391.1 - 4.4e-20 72.2 0.2 7.5e-20 71.4 0.2 1.4 1 0 0 1 1 1 1 DOMON domain Bact_lectin PF18483.1 PIK52391.1 - 0.012 15.7 0.2 0.16 12.0 0.1 2.2 2 0 0 2 2 2 0 Bacterial lectin DUF4958 PF16319.5 PIK52392.1 - 0.061 11.3 0.0 0.084 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) TACC_C PF05010.14 PIK52393.1 - 6.8e-57 192.5 33.4 6.8e-57 192.5 33.4 1.9 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 PIK52393.1 - 0.0011 18.3 24.3 0.0011 18.3 24.3 2.4 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 PIK52393.1 - 0.017 15.5 17.7 0.017 15.5 17.7 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4200) Filament PF00038.21 PIK52393.1 - 0.077 12.6 30.5 0.13 11.9 24.2 2.7 1 1 1 2 2 2 0 Intermediate filament protein Prominin PF05478.11 PIK52393.1 - 0.68 7.8 15.1 1.1 7.1 15.1 1.3 1 0 0 1 1 1 0 Prominin SOAR PF16533.5 PIK52393.1 - 1.9 8.5 16.5 2.8 8.0 5.8 2.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region DUF3584 PF12128.8 PIK52393.1 - 2.1 5.8 32.2 0.016 12.8 23.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 PIK52393.1 - 2.5 8.1 15.4 0.69 10.0 4.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4349 PF14257.6 PIK52393.1 - 6.8 6.1 11.5 0.72 9.3 1.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Fib_alpha PF08702.10 PIK52393.1 - 7.9 6.7 24.1 2.1 8.5 9.6 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Nucleos_tra2_C PF07662.13 PIK52394.1 - 1.1e-70 237.7 1.5 2.2e-70 236.7 1.5 1.5 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Ni_hydr_CYTB PF01292.20 PIK52394.1 - 0.00064 19.4 0.9 0.0018 17.9 0.9 1.8 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 TB2_DP1_HVA22 PF03134.19 PIK52394.1 - 0.07 13.1 0.3 0.07 13.1 0.3 2.2 2 0 0 2 2 2 0 TB2/DP1, HVA22 family DUF2157 PF09925.9 PIK52394.1 - 0.39 10.5 5.4 0.14 11.9 0.6 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Mtc PF03820.17 PIK52395.1 - 4.4e-88 295.3 2.9 1e-51 175.9 3.2 2.1 1 1 1 2 2 2 2 Tricarboxylate carrier SWIB PF02201.18 PIK52396.1 - 1.5e-25 88.8 2.0 1.9e-25 88.5 0.2 2.1 3 0 0 3 3 3 1 SWIB/MDM2 domain DEK_C PF08766.11 PIK52396.1 - 1.6e-15 56.8 2.6 4.1e-15 55.4 2.6 1.8 1 0 0 1 1 1 1 DEK C terminal domain CAC1F_C PF16885.5 PIK52396.1 - 0.085 12.5 8.8 0.12 12.0 8.8 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CDC45 PF02724.14 PIK52396.1 - 1.3 7.2 16.3 1.7 6.9 16.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF826 PF05696.11 PIK52396.1 - 5.4 7.2 8.2 0.55 10.3 3.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF826) Cyclin_N PF00134.23 PIK52397.1 - 3.6e-19 68.8 1.7 7.2e-19 67.8 0.5 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK52397.1 - 2.1e-17 63.3 0.9 7.1e-17 61.6 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain DUF3011 PF11218.8 PIK52398.1 - 0.02 14.9 0.1 0.025 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) FapA PF03961.13 PIK52398.1 - 0.049 12.2 6.5 0.06 11.9 6.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A PRKG1_interact PF15898.5 PIK52398.1 - 0.29 12.0 10.5 0.43 11.5 10.5 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain CENP-H PF05837.12 PIK52398.1 - 0.67 10.4 11.0 1.3 9.4 11.0 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) RIC3 PF15361.6 PIK52398.1 - 1.1 9.6 4.7 0.21 11.9 0.7 1.8 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 7TMR-HDED PF07697.11 PIK52398.1 - 1.3 9.2 6.4 3.3 7.8 6.4 1.7 1 1 0 1 1 1 0 7TM-HD extracellular IL11 PF07400.11 PIK52399.1 - 0.029 14.0 0.2 0.029 14.0 0.2 2.5 2 0 0 2 2 2 0 Interleukin 11 PRIMA1 PF16101.5 PIK52399.1 - 2 8.4 13.9 0.71 9.9 10.1 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP59_mtransfer PF11735.8 PIK52399.1 - 4.2 7.0 8.4 2.1 8.0 5.0 2.1 2 0 0 2 2 2 0 Cryptococcal mannosyltransferase 1 CCDC142 PF14923.6 PIK52401.1 - 0.00021 20.2 0.0 0.00043 19.1 0.0 1.5 1 0 0 1 1 1 1 Coiled-coil protein 142 zf-C2H2_8 PF15909.5 PIK52401.1 - 0.055 13.8 0.9 0.16 12.3 0.9 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon CCDC142 PF14923.6 PIK52402.1 - 6.8e-51 173.4 3.9 1.5e-37 129.4 0.0 2.0 1 1 1 2 2 2 2 Coiled-coil protein 142 RINT1_TIP1 PF04437.13 PIK52402.1 - 0.024 13.6 0.0 0.034 13.0 0.0 1.2 1 0 0 1 1 1 0 RINT-1 / TIP-1 family SAM_PNT PF02198.16 PIK52403.1 - 7e-05 22.7 0.6 0.00012 22.0 0.6 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 PIK52404.1 - 1.1e-15 57.7 0.0 1.4e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 PIK52404.1 - 2.1e-10 40.0 0.1 2.9e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 PIK52404.1 - 1.4e-07 31.0 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK52404.1 - 0.00012 22.1 0.2 0.15 12.0 0.2 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family DSPc PF00782.20 PIK52405.1 - 1e-36 125.7 0.0 1.6e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK52405.1 - 6.9e-11 42.6 0.0 2.8e-09 37.4 0.0 2.3 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 PIK52405.1 - 7.4e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 PIK52405.1 - 0.0021 17.0 0.0 0.025 13.5 0.0 2.1 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain PTPlike_phytase PF14566.6 PIK52405.1 - 0.012 15.7 0.0 0.042 14.0 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 PIK52405.1 - 0.059 13.7 0.0 0.76 10.1 0.0 2.2 2 0 0 2 2 2 0 Rit1 DUSP-like domain NHL PF01436.21 PIK52406.1 - 3.3e-15 55.2 1.8 5.6e-06 26.1 0.0 4.9 5 0 0 5 5 5 2 NHL repeat SBBP PF06739.11 PIK52406.1 - 1.1e-08 34.9 0.0 0.0052 16.7 0.0 2.6 2 0 0 2 2 2 2 Beta-propeller repeat SGL PF08450.12 PIK52406.1 - 4.2e-08 33.1 0.1 0.0063 16.1 0.0 3.0 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region zf-C3HC4_4 PF15227.6 PIK52406.1 - 3.5e-07 30.3 11.6 3.5e-07 30.3 11.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK52406.1 - 1.9e-06 27.6 13.2 1.9e-06 27.6 13.2 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK52406.1 - 5e-06 26.6 5.8 5e-06 26.6 5.8 3.4 2 1 1 3 3 1 1 B-box zinc finger zf-C3HC4_2 PF13923.6 PIK52406.1 - 8.9e-06 25.5 12.3 8.9e-06 25.5 12.3 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK52406.1 - 2.6e-05 24.2 11.2 6.6e-05 22.8 11.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK52406.1 - 9.1e-05 22.7 13.3 9.1e-05 22.7 13.3 2.3 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK52406.1 - 0.00062 19.6 10.7 0.00062 19.6 10.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Filamin PF00630.19 PIK52406.1 - 0.0016 19.2 0.0 0.0072 17.1 0.0 2.1 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-RING_6 PF14835.6 PIK52406.1 - 0.0019 18.0 4.0 0.005 16.7 4.0 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 PIK52406.1 - 0.0028 17.6 11.4 0.0028 17.6 11.4 2.4 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK52406.1 - 0.014 15.3 12.1 0.014 15.3 12.1 2.7 2 1 0 2 2 1 0 Prokaryotic RING finger family 4 DUF2724 PF10893.8 PIK52406.1 - 0.035 13.9 0.6 0.22 11.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) zf-ANAPC11 PF12861.7 PIK52406.1 - 6.4 6.9 16.5 0.045 13.8 6.1 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_1 PF00076.22 PIK52407.1 - 5.1e-12 45.4 0.2 1.2e-11 44.3 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK52407.1 - 9.7e-05 22.3 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 PIK52407.1 - 0.0089 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif SET_assoc PF11767.8 PIK52407.1 - 0.05 13.3 0.1 0.091 12.4 0.1 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 PIK52407.1 - 0.069 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK52407.1 - 0.21 11.6 0.0 0.21 11.6 0.0 2.4 3 0 0 3 3 3 0 RNA binding motif LSDAT_euk PF18139.1 PIK52408.1 - 6.4e-39 134.0 0.1 1.1e-38 133.2 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 PIK52408.1 - 5.4e-11 42.1 0.0 1.1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote DUF2704 PF10866.8 PIK52408.1 - 0.011 15.6 0.0 0.051 13.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2704) DUF3631 PF12307.8 PIK52408.1 - 0.015 15.6 0.1 0.067 13.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3631) POTRA_2 PF08479.11 PIK52408.1 - 0.11 12.3 0.1 0.83 9.5 0.0 2.3 2 0 0 2 2 2 0 POTRA domain, ShlB-type Ion_trans PF00520.31 PIK52410.1 - 4.5e-06 26.1 7.5 6.1e-06 25.6 7.5 1.2 1 0 0 1 1 1 1 Ion transport protein 7tm_1 PF00001.21 PIK52411.1 - 2.4e-23 82.8 4.1 2.9e-23 82.5 4.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK52411.1 - 3.6e-05 23.6 1.2 5.2e-05 23.1 1.2 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK52411.1 - 0.00021 20.8 3.7 0.00029 20.3 3.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK52411.1 - 0.00023 20.9 6.1 0.00032 20.4 6.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CbtA PF09490.10 PIK52411.1 - 0.59 9.8 5.1 1 9.1 5.0 1.5 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Thg1 PF04446.12 PIK52412.1 - 1.7e-52 176.7 0.3 2.6e-52 176.1 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 PIK52412.1 - 2.1e-30 105.4 0.2 3.8e-30 104.6 0.2 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain GGDEF PF00990.21 PIK52412.1 - 0.042 13.6 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Diguanylate cyclase, GGDEF domain L51_S25_CI-B8 PF05047.16 PIK52413.1 - 5.6e-11 42.2 0.1 2.9e-09 36.7 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CotJB PF12652.7 PIK52413.1 - 0.15 12.3 0.9 0.32 11.2 0.5 1.6 2 0 0 2 2 2 0 CotJB protein NOC3p PF07540.11 PIK52414.1 - 1.1e-25 89.9 0.6 1.1e-25 89.9 0.6 3.2 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 PIK52414.1 - 2.4e-23 83.1 0.9 2.4e-23 83.1 0.9 3.2 3 1 1 4 4 4 1 CBF/Mak21 family UPF0242 PF06785.11 PIK52414.1 - 0.0019 18.4 1.7 0.0019 18.4 1.7 3.8 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0242) N-terminus Kelch_4 PF13418.6 PIK52415.1 - 9.2e-15 54.4 12.0 0.0026 17.7 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK52415.1 - 5.8e-14 51.7 28.7 0.00024 21.0 0.1 7.6 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 PIK52415.1 - 1.9e-12 47.0 27.1 0.00015 21.9 0.2 7.1 6 1 1 7 7 7 4 Kelch motif Kelch_2 PF07646.15 PIK52415.1 - 3.1e-12 46.0 8.9 0.00017 21.4 0.1 5.9 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 PIK52415.1 - 9.2e-12 44.4 16.2 0.00086 18.8 0.3 7.3 6 1 0 6 6 6 3 Kelch motif PSI PF01437.25 PIK52415.1 - 4e-07 30.5 32.6 7.5e-05 23.2 15.8 7.9 7 2 2 9 9 9 4 Plexin repeat Kelch_3 PF13415.6 PIK52415.1 - 1.6e-05 25.1 18.0 0.18 12.2 0.0 6.8 7 0 0 7 7 7 3 Galactose oxidase, central domain EGF_2 PF07974.13 PIK52415.1 - 0.00022 21.5 38.9 0.00075 19.8 15.4 7.0 6 1 0 6 6 6 2 EGF-like domain EGF_Tenascin PF18720.1 PIK52415.1 - 0.006 16.6 11.0 0.006 16.6 11.0 6.6 7 1 0 7 7 7 1 Tenascin EGF domain DJ-1_PfpI PF01965.24 PIK52416.1 - 0.00027 20.8 0.2 0.00078 19.3 0.2 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family CLAMP PF14769.6 PIK52417.1 - 3.2e-16 59.6 0.0 5.8e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 DUF356 PF04009.12 PIK52417.1 - 0.099 12.9 0.1 0.28 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF356) SH3_9 PF14604.6 PIK52418.1 - 2.6e-28 97.6 0.4 9.3e-17 60.6 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK52418.1 - 4.9e-28 96.5 4.8 1.9e-15 56.2 0.6 2.2 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 PIK52418.1 - 2.4e-23 81.5 0.9 2.6e-14 52.6 0.2 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 PIK52418.1 - 5.7e-09 36.1 5.8 8.4e-05 22.8 0.3 2.7 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_10 PF17902.1 PIK52418.1 - 0.00028 20.9 1.8 0.0017 18.4 0.2 2.3 2 0 0 2 2 2 1 SH3 domain rve PF00665.26 PIK52419.1 - 3.6e-16 59.4 0.0 5.7e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK52420.1 - 8.2e-13 48.3 0.0 2.4e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52420.1 - 0.00024 21.4 0.0 0.0015 18.8 0.0 2.1 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 PIK52420.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.4 1 1 0 1 1 1 0 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK52421.1 - 7e-06 25.7 0.1 1e-05 25.2 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDZ PF00595.24 PIK52422.1 - 0.0013 19.1 0.1 0.0031 17.8 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK52422.1 - 0.0058 16.9 0.1 0.024 15.0 0.0 2.0 3 0 0 3 3 3 1 PDZ domain PDZ_6 PF17820.1 PIK52422.1 - 0.0087 15.9 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain hnRNP_Q_AcD PF18360.1 PIK52422.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Peptidase_C2 PF00648.21 PIK52423.1 - 1e-27 97.0 2.5 1.4e-27 96.5 2.5 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 PIK52423.1 - 7.2e-15 55.5 0.2 4.7e-09 36.6 0.0 2.4 1 1 1 2 2 2 2 Calpain large subunit, domain III C2 PF00168.30 PIK52423.1 - 4e-06 27.1 0.0 9.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain Peptidase_C2 PF00648.21 PIK52424.1 - 9.6e-61 205.4 0.0 1.2e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease CUB PF00431.20 PIK52425.1 - 0.041 14.2 0.0 0.054 13.8 0.0 1.2 1 0 0 1 1 1 0 CUB domain BCS1_N PF08740.11 PIK52426.1 - 1.1e-44 152.6 1.3 1.7e-44 152.1 1.3 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 PIK52426.1 - 1e-19 71.2 0.0 1.9e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK52426.1 - 0.00035 20.9 0.0 0.0011 19.3 0.0 1.9 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 PIK52426.1 - 0.00059 19.8 0.0 0.0014 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 PIK52426.1 - 0.001 19.0 0.2 0.027 14.4 0.0 2.2 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 PIK52426.1 - 0.0019 18.6 0.0 0.01 16.2 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 PIK52426.1 - 0.0044 17.5 0.0 0.012 16.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 PIK52426.1 - 0.0046 17.1 0.0 0.016 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK52426.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 PIK52426.1 - 0.0077 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 PIK52426.1 - 0.036 13.8 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK52426.1 - 0.07 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 PIK52426.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 PIK52426.1 - 0.13 12.3 0.0 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Glyco_transf_22 PF03901.17 PIK52427.1 - 2.7e-47 161.9 19.8 1.2e-25 90.6 0.8 2.1 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family Methyltransf_3 PF01596.17 PIK52428.1 - 2.4e-26 92.2 0.0 3.4e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 PIK52428.1 - 1.1e-07 32.4 0.0 2.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 PIK52428.1 - 1.8e-07 32.1 0.0 3.6e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK52428.1 - 4.7e-07 29.7 0.1 7.3e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK52428.1 - 0.00015 21.6 0.0 0.0011 18.8 0.0 2.0 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 PIK52428.1 - 0.00075 20.1 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 PIK52428.1 - 0.00083 19.1 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_32 PF13679.6 PIK52428.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF1188 PF06690.11 PIK52428.1 - 0.011 15.3 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Methyltransf_12 PF08242.12 PIK52428.1 - 0.016 15.9 0.0 0.03 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Spermine_synth PF01564.17 PIK52428.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain AAA_31 PF13614.6 PIK52428.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NmrA PF05368.13 PIK52430.1 - 9.4e-26 90.8 0.2 1.3e-25 90.3 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 PIK52430.1 - 1.9e-17 63.7 0.5 4.6e-17 62.5 0.5 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 PIK52430.1 - 0.00094 18.7 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 PIK52430.1 - 0.019 15.6 0.2 0.056 14.0 0.2 2.0 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 PIK52430.1 - 0.019 15.2 0.1 0.019 15.2 0.1 1.9 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 PIK52430.1 - 0.062 12.7 0.4 0.18 11.2 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase GTP_EFTU PF00009.27 PIK52431.1 - 2.9e-62 209.7 0.2 7.8e-62 208.3 0.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 PIK52431.1 - 1.6e-37 127.9 0.0 3.2e-37 127.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 PIK52431.1 - 2.6e-30 104.3 0.0 5.3e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 PIK52431.1 - 3.5e-28 97.5 0.0 1.1e-27 95.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 PIK52431.1 - 2.7e-14 53.3 0.0 6.6e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 PIK52431.1 - 6.8e-08 32.4 0.0 2.8e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 PIK52431.1 - 0.0032 17.9 0.0 0.3 11.6 0.0 2.7 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 PIK52431.1 - 0.0066 16.5 0.1 0.015 15.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Sex_peptide PF08138.11 PIK52431.1 - 0.043 14.0 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Sex peptide (SP) family AIG1 PF04548.16 PIK52431.1 - 0.054 12.8 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 AIG1 family DUF442 PF04273.13 PIK52431.1 - 0.12 12.4 0.0 16 5.6 0.0 2.5 2 0 0 2 2 2 0 Putative phosphatase (DUF442) DUF3752 PF12572.8 PIK52432.1 - 2.7e-26 92.9 18.8 2.7e-26 92.9 18.8 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3752) TMEM154 PF15102.6 PIK52433.1 - 0.00035 20.5 0.1 0.00035 20.5 0.1 1.8 2 0 0 2 2 2 1 TMEM154 protein family Neur_chan_memb PF02932.16 PIK52433.1 - 0.0015 18.6 0.0 0.0018 18.4 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region TMEM51 PF15345.6 PIK52433.1 - 0.0016 18.4 0.3 0.0018 18.2 0.3 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 EphA2_TM PF14575.6 PIK52433.1 - 0.0064 17.3 0.3 0.01 16.7 0.3 1.5 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain PRIMA1 PF16101.5 PIK52433.1 - 0.019 15.0 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Cadherin_C_2 PF16492.5 PIK52433.1 - 0.021 15.6 0.0 0.039 14.7 0.0 1.5 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal CYYR1 PF10873.8 PIK52433.1 - 0.022 15.2 0.0 0.054 14.0 0.0 1.6 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 GAPT PF11770.8 PIK52433.1 - 0.024 14.5 0.5 0.046 13.6 0.5 1.5 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) Herpes_gE PF02480.16 PIK52433.1 - 0.03 13.1 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Orf78 PF06024.12 PIK52433.1 - 0.038 14.3 2.2 0.058 13.7 0.1 2.2 2 1 0 2 2 2 0 Orf78 (ac78) FixQ PF05545.11 PIK52433.1 - 0.048 13.6 0.5 0.51 10.4 0.1 2.4 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ CD34_antigen PF06365.12 PIK52433.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF5305 PF17231.2 PIK52433.1 - 0.06 12.7 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Insulin_TMD PF17870.1 PIK52433.1 - 0.13 12.3 1.8 0.25 11.4 1.8 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FAM176 PF14851.6 PIK52433.1 - 0.17 11.5 2.8 0.53 9.9 2.8 1.9 1 1 0 1 1 1 0 FAM176 family Orthoreo_P10 PF07204.11 PIK52433.1 - 0.18 11.8 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 S1FA PF04689.13 PIK52433.1 - 0.2 11.8 0.7 0.43 10.8 0.7 1.5 1 0 0 1 1 1 0 DNA binding protein S1FA TRP PF06011.12 PIK52433.1 - 0.28 9.9 0.7 0.36 9.5 0.1 1.3 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel TssO PF17561.2 PIK52433.1 - 0.42 10.7 1.8 0.76 9.9 0.2 2.0 1 1 1 2 2 2 0 Type VI secretion system, TssO SRCR PF00530.18 PIK52434.1 - 6.3e-17 61.9 0.3 1.3e-16 60.9 0.3 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain GAIN PF16489.5 PIK52434.1 - 9e-05 22.0 2.7 0.00017 21.1 2.7 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain SRCR_2 PF15494.6 PIK52434.1 - 0.00085 19.8 1.3 0.0027 18.2 0.2 2.5 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Carboxyl_trans PF01039.22 PIK52435.1 - 2.2e-186 620.3 0.1 2.7e-186 620.0 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain Ependymin PF00811.18 PIK52436.1 - 0.085 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Ependymin DUF615 PF04751.14 PIK52436.1 - 0.1 12.6 0.4 0.13 12.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF615) TMEM151 PF14857.6 PIK52437.1 - 1.3e-114 383.5 0.4 1.7e-114 383.1 0.4 1.2 1 0 0 1 1 1 1 TMEM151 family TMEM252 PF15664.5 PIK52437.1 - 0.059 13.1 0.1 0.24 11.1 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 252 family Tmem26 PF09772.9 PIK52438.1 - 4.9e-36 124.6 0.6 7.2e-24 84.6 0.0 2.1 2 0 0 2 2 2 2 Transmembrane protein 26 Tmem26 PF09772.9 PIK52439.1 - 3.2e-52 177.7 3.1 4e-52 177.4 3.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 Tmem26 PF09772.9 PIK52440.1 - 1.8e-70 237.5 10.6 2.5e-70 237.1 10.6 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 Gp58 PF07902.11 PIK52441.1 - 0.11 10.7 0.0 0.13 10.6 0.0 1.0 1 0 0 1 1 1 0 gp58-like protein Methyltransf_25 PF13649.6 PIK52443.1 - 2.5e-06 28.1 0.0 3.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK52443.1 - 8.7e-05 23.1 0.0 0.00015 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK52443.1 - 0.0014 18.2 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 PIK52443.1 - 0.0022 17.8 0.0 0.0059 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK52443.1 - 0.047 13.5 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Osmo_CC PF08946.10 PIK52443.1 - 0.097 12.9 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Neur_chan_LBD PF02931.23 PIK52444.1 - 3.4e-10 39.7 1.4 5.5e-10 39.1 1.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK52444.1 - 2.8e-05 24.3 11.0 7.7e-05 22.9 11.0 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EGF_CA PF07645.15 PIK52445.1 - 1.1e-38 131.2 118.5 5.8e-09 36.0 9.9 8.3 7 2 1 8 8 8 7 Calcium-binding EGF domain cEGF PF12662.7 PIK52445.1 - 4.5e-10 39.3 56.4 0.0032 17.4 4.5 8.7 8 0 0 8 8 8 6 Complement Clr-like EGF-like hEGF PF12661.7 PIK52445.1 - 8.4e-08 32.6 99.8 0.007 17.0 4.5 11.8 11 0 0 11 11 11 7 Human growth factor-like EGF EGF PF00008.27 PIK52445.1 - 1.4e-07 31.7 103.2 0.0089 16.3 5.6 10.4 7 2 2 9 9 9 7 EGF-like domain Plasmod_Pvs28 PF06247.11 PIK52445.1 - 3.9e-06 27.1 65.8 0.047 14.0 1.0 8.1 5 2 2 7 7 7 4 Pvs28 EGF domain EGF_3 PF12947.7 PIK52445.1 - 0.002 18.3 97.4 0.018 15.2 6.1 10.0 6 3 3 9 9 9 5 EGF domain FXa_inhibition PF14670.6 PIK52445.1 - 0.023 15.0 100.1 0.26 11.6 6.2 9.2 7 2 2 9 9 9 0 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK52446.1 - 8e-29 99.6 87.0 7.4e-10 38.9 10.0 6.8 5 2 1 6 6 6 4 Calcium-binding EGF domain cEGF PF12662.7 PIK52446.1 - 1.1e-15 57.2 43.9 0.0013 18.6 0.3 7.3 6 1 0 6 6 6 6 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK52446.1 - 4.3e-10 39.6 71.0 6.5e-05 23.0 2.2 7.1 5 3 1 6 6 6 4 EGF domain FXa_inhibition PF14670.6 PIK52446.1 - 1.1e-06 28.8 65.2 0.27 11.6 7.2 7.0 2 2 4 6 6 6 5 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 PIK52446.1 - 4.8e-06 26.8 62.8 0.02 15.2 5.0 6.6 6 0 0 6 6 6 4 Pvs28 EGF domain EB PF01683.18 PIK52446.1 - 0.0006 20.0 75.0 0.0011 19.2 4.8 6.3 2 1 4 6 6 6 3 EB module EGF_MSP1_1 PF12946.7 PIK52446.1 - 0.00088 19.3 61.1 0.11 12.6 5.0 6.5 6 0 0 6 6 6 4 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK52446.1 - 0.006 16.9 2.3 0.006 16.9 2.3 7.7 4 4 0 6 6 6 1 EGF-like domain hEGF PF12661.7 PIK52446.1 - 0.028 15.1 3.9 0.028 15.1 3.9 9.2 10 1 0 10 10 8 0 Human growth factor-like EGF EGF PF00008.27 PIK52446.1 - 0.14 12.5 74.2 0.09 13.1 2.9 7.7 6 2 1 7 7 7 0 EGF-like domain TIL PF01826.17 PIK52446.1 - 0.8 10.0 77.7 1.8 8.9 6.7 6.6 3 3 3 6 6 6 0 Trypsin Inhibitor like cysteine rich domain Reprolysin_5 PF13688.6 PIK52447.1 - 7.9e-28 97.9 0.6 7.9e-28 97.9 0.6 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 PIK52447.1 - 1.5e-23 83.7 0.6 1.5e-23 83.7 0.6 1.6 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK52447.1 - 2e-18 67.1 0.1 4.8e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 PIK52447.1 - 1.6e-12 47.8 0.0 3.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM17_MPD PF16698.5 PIK52447.1 - 2.6e-07 30.9 13.0 2.6e-07 30.9 13.0 3.0 2 1 0 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 Reprolysin_4 PF13583.6 PIK52447.1 - 1.8e-06 27.8 0.6 4.9e-06 26.3 0.6 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 PIK52447.1 - 2.6e-06 27.5 0.0 2.6e-06 27.5 0.0 2.8 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M43 PF05572.13 PIK52447.1 - 0.0032 17.4 0.2 0.0032 17.4 0.2 2.0 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A UPF0370 PF13980.6 PIK52447.1 - 0.03 14.3 5.1 0.059 13.4 5.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) UQ_con PF00179.26 PIK52448.1 - 6.2e-28 97.2 0.1 5.7e-27 94.1 0.0 2.3 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK52448.1 - 0.00068 19.5 0.0 0.0018 18.1 0.0 1.8 2 0 0 2 2 2 1 UEV domain RWD PF05773.22 PIK52448.1 - 0.0019 18.5 0.0 0.0041 17.4 0.0 1.7 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK52448.1 - 0.003 17.2 0.0 0.0059 16.3 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B zf-CCHC PF00098.23 PIK52449.1 - 4.6e-05 23.3 5.0 4.6e-05 23.3 5.0 2.3 2 0 0 2 2 2 1 Zinc knuckle SabA_adhesion PF18304.1 PIK52449.1 - 0.02 14.1 0.1 0.023 14.0 0.1 1.1 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain Phage_GPO PF05929.11 PIK52449.1 - 0.033 13.8 3.6 0.04 13.6 3.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase SlyX PF04102.12 PIK52449.1 - 0.14 12.8 7.5 1.9 9.2 0.4 2.5 3 0 0 3 3 3 0 SlyX RT_RNaseH PF17917.1 PIK52450.1 - 1.5e-30 105.6 0.0 3e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK52450.1 - 5.9e-27 93.6 0.0 1.1e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52450.1 - 9.8e-20 71.0 0.0 1.7e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.14 PIK52450.1 - 0.0002 21.2 0.0 0.00046 20.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain DUF3613 PF12266.8 PIK52450.1 - 0.021 14.6 0.6 0.94 9.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) UQ_con PF00179.26 PIK52451.1 - 2e-31 108.5 0.1 3.1e-30 104.7 0.0 2.2 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK52451.1 - 6.5e-05 22.8 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 PIK52451.1 - 0.0067 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 PIK52451.1 - 0.0088 16.3 0.1 0.021 15.1 0.0 1.8 2 1 0 2 2 2 1 RWD domain Nucleo_P87 PF07267.11 PIK52451.1 - 0.11 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 O-FucT PF10250.9 PIK52452.1 - 5.8e-40 138.0 0.1 7e-40 137.8 0.1 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase baeRF_family10 PF18854.1 PIK52452.1 - 0.1 12.9 0.2 0.18 12.1 0.1 1.4 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 baeRF_family12 PF18856.1 PIK52452.1 - 0.11 13.0 1.2 0.16 12.5 1.0 1.5 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Pkinase PF00069.25 PIK52453.1 - 2e-33 115.9 0.0 2.9e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52453.1 - 1.1e-29 103.5 0.0 1.6e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK52453.1 - 0.00046 19.1 0.0 0.00075 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Activin_recp PF01064.23 PIK52453.1 - 0.011 16.9 14.2 0.011 16.9 14.2 1.8 2 0 0 2 2 2 0 Activin types I and II receptor domain FTA2 PF13095.6 PIK52453.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ecTbetaR2 PF08917.10 PIK52453.1 - 2.4 8.1 11.1 58 3.7 11.1 2.5 1 1 0 1 1 1 0 Transforming growth factor beta receptor 2 ectodomain ORC4_C PF14629.6 PIK52454.1 - 1.9e-48 164.7 0.1 3.7e-48 163.8 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 PIK52454.1 - 1.9e-10 41.4 0.7 4.1e-10 40.3 0.7 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK52454.1 - 4.7e-09 36.8 0.1 9.5e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK52454.1 - 5.9e-08 33.1 0.3 1.6e-07 31.7 0.2 1.8 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK52454.1 - 2.4e-05 24.3 1.1 0.00011 22.2 1.1 2.2 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 PIK52454.1 - 0.00014 21.9 0.1 0.00028 20.9 0.1 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 PIK52454.1 - 0.0012 19.4 0.1 0.0021 18.6 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 PIK52454.1 - 0.0033 17.0 0.0 0.0064 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 PIK52454.1 - 0.0046 16.7 0.0 0.0084 15.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein T2SSE PF00437.20 PIK52454.1 - 0.0083 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_25 PF13481.6 PIK52454.1 - 0.0084 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.17 PIK52454.1 - 0.012 15.7 1.4 0.11 12.6 0.2 2.7 2 1 1 3 3 3 0 Helicase HerA, central domain Methyltransf_28 PF02636.17 PIK52454.1 - 0.012 15.2 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase AAA_21 PF13304.6 PIK52454.1 - 0.02 14.7 0.7 4.8 6.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF2075 PF09848.9 PIK52454.1 - 0.022 14.0 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 PIK52454.1 - 0.037 13.8 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 PIK52454.1 - 0.037 14.2 0.1 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 PIK52454.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 PIK52454.1 - 0.059 12.8 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK52454.1 - 0.063 13.7 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 PIK52454.1 - 0.07 12.3 0.2 0.4 9.8 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 PIK52454.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 PIK52454.1 - 0.085 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 PIK52454.1 - 0.092 12.1 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein TAF6_C PF07571.13 PIK52454.1 - 0.092 13.1 0.0 1 9.7 0.0 2.6 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain AAA_30 PF13604.6 PIK52454.1 - 0.094 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK52454.1 - 0.097 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 PIK52454.1 - 0.12 12.7 0.1 0.25 11.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK52454.1 - 0.16 12.0 0.0 0.97 9.4 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 PIK52455.1 - 1.6e-102 341.4 0.1 2.9e-102 340.5 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK52455.1 - 2.1e-35 121.3 1.4 4.8e-35 120.2 1.4 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK52455.1 - 4.1e-28 97.6 1.6 3.3e-27 94.7 1.3 2.6 2 0 0 2 2 2 1 MCM AAA-lid domain MCM6_C PF18263.1 PIK52455.1 - 3.1e-20 72.4 3.0 3.1e-20 72.4 3.0 2.6 3 0 0 3 3 3 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 PIK52455.1 - 5.2e-16 59.1 2.0 5.2e-16 59.1 2.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 PIK52455.1 - 8.7e-08 31.8 0.0 3.7e-07 29.7 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 PIK52455.1 - 7.2e-05 22.7 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK52455.1 - 0.00052 20.0 0.1 0.0018 18.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF2428 PF10350.9 PIK52455.1 - 0.0021 17.3 1.0 0.0038 16.5 1.0 1.4 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) Sigma54_activat PF00158.26 PIK52455.1 - 0.0024 17.6 0.0 0.0054 16.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 PIK52455.1 - 0.029 15.0 1.6 0.16 12.7 0.9 2.7 2 1 0 2 2 1 0 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 PIK52455.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA lid domain GRAM PF02893.20 PIK52456.1 - 2.6e-15 56.3 0.1 4e-15 55.7 0.1 1.2 1 0 0 1 1 1 1 GRAM domain bPH_3 PF14470.6 PIK52456.1 - 0.00079 19.7 0.3 0.0013 19.1 0.3 1.3 1 0 0 1 1 1 1 Bacterial PH domain Vps36_ESCRT-II PF11605.8 PIK52456.1 - 0.02 15.1 0.1 0.041 14.1 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Ribosomal_L9_N PF01281.19 PIK52457.1 - 2e-16 59.2 0.2 3.5e-16 58.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Flavokinase PF01687.17 PIK52458.1 - 1.1e-35 122.3 0.0 1.3e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase EGF PF00008.27 PIK52459.1 - 5.4e-07 29.8 6.5 5.4e-07 29.8 6.5 2.3 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 PIK52459.1 - 0.0016 18.7 7.3 0.0016 18.7 7.3 2.6 1 1 1 2 2 2 1 EGF-like domain PAG PF15347.6 PIK52459.1 - 0.0074 15.3 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched EphA2_TM PF14575.6 PIK52459.1 - 0.052 14.4 0.2 0.091 13.6 0.2 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain hEGF PF12661.7 PIK52459.1 - 0.064 13.9 3.7 0.064 13.9 3.7 3.2 3 0 0 3 3 3 0 Human growth factor-like EGF WD40 PF00400.32 PIK52460.1 - 1.4e-13 51.0 18.6 0.0031 18.3 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK52460.1 - 0.03 14.6 0.4 0.34 11.2 0.1 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Hat1_N PF10394.9 PIK52461.1 - 1.5e-07 31.8 0.0 1.7e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Mito_carr PF00153.27 PIK52462.1 - 3.4e-68 225.6 0.2 8.3e-24 83.3 0.1 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 PIK52462.1 - 1e-13 49.8 0.7 8.9e-07 28.0 0.1 4.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 PIK52462.1 - 3.3e-12 45.3 3.7 1.6e-05 24.4 0.1 4.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 PIK52462.1 - 2.6e-09 37.4 3.1 0.00057 20.3 0.7 3.9 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK52462.1 - 1.5e-06 27.4 0.1 1.5e-06 27.4 0.1 3.4 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 PIK52462.1 - 7.7e-05 22.5 5.0 0.0037 17.1 0.1 4.2 4 1 0 5 5 5 1 EF-hand domain pair EF-hand_10 PF14788.6 PIK52462.1 - 0.067 13.1 0.4 0.99 9.3 0.1 2.5 2 0 0 2 2 2 0 EF hand DUF4734 PF15881.5 PIK52462.1 - 0.081 13.1 0.4 0.22 11.7 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) EF-hand_like PF09279.11 PIK52462.1 - 0.67 10.5 3.3 13 6.3 0.4 3.2 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like FGGY_N PF00370.21 PIK52463.1 - 3.9e-21 75.7 0.0 9.8e-19 67.9 0.0 2.4 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 PIK52463.1 - 8.8e-21 74.5 0.0 2.6e-20 73.0 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain EGF PF00008.27 PIK52464.1 - 1.2e-76 252.5 178.2 1.8e-09 37.7 10.4 15.0 14 0 0 14 14 14 13 EGF-like domain hEGF PF12661.7 PIK52464.1 - 1.9e-42 142.5 172.1 5.2e-07 30.1 8.0 16.6 16 0 0 16 16 16 12 Human growth factor-like EGF TSP_1 PF00090.19 PIK52464.1 - 5.3e-14 52.2 8.5 5.3e-14 52.2 8.5 5.3 5 1 1 6 6 6 1 Thrombospondin type 1 domain EGF_CA PF07645.15 PIK52464.1 - 5.1e-09 36.2 206.4 0.00016 21.8 5.2 14.9 7 2 8 15 15 15 10 Calcium-binding EGF domain EGF_3 PF12947.7 PIK52464.1 - 0.015 15.5 3.1 0.015 15.5 3.1 14.4 12 2 1 13 13 13 0 EGF domain Laminin_G_3 PF13385.6 PIK52464.1 - 0.02 15.0 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 PIK52464.1 - 0.13 12.9 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain rve PF00665.26 PIK52465.1 - 1.2e-13 51.2 0.1 1.9e-13 50.7 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52465.1 - 0.0036 17.0 0.0 0.0084 15.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Peptidase_C48 PF02902.19 PIK52466.1 - 0.01 15.7 0.0 0.01 15.7 0.0 7.9 8 4 0 8 8 8 0 Ulp1 protease family, C-terminal catalytic domain Sushi PF00084.20 PIK52467.1 - 8.6e-42 141.5 103.8 1.4e-06 28.8 3.1 12.5 13 0 0 13 13 13 9 Sushi repeat (SCR repeat) HYR PF02494.16 PIK52467.1 - 1e-37 128.3 18.7 2.8e-12 46.8 0.6 5.8 5 0 0 5 5 5 4 HYR domain EGF PF00008.27 PIK52467.1 - 3.6e-33 113.5 108.5 6e-08 32.8 9.1 11.4 10 0 0 10 10 10 7 EGF-like domain hEGF PF12661.7 PIK52467.1 - 1.1e-07 32.2 103.3 5.7e-05 23.6 5.1 12.3 11 0 0 11 11 11 6 Human growth factor-like EGF EGF_CA PF07645.15 PIK52467.1 - 0.0057 16.8 9.6 0.0057 16.8 9.6 17.3 14 1 4 19 19 19 4 Calcium-binding EGF domain DUF5011 PF16403.5 PIK52467.1 - 0.011 15.8 1.1 3.1 8.0 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) DUF4625 PF15418.6 PIK52467.1 - 0.054 13.7 0.0 21 5.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4625) SusE PF14292.6 PIK52467.1 - 0.11 12.8 0.7 0.23 11.7 0.7 1.5 1 0 0 1 1 1 0 SusE outer membrane protein FlgD_ig PF13860.6 PIK52467.1 - 0.42 10.5 1.3 35 4.3 0.0 3.8 4 0 0 4 4 4 0 FlgD Ig-like domain BLOC1S3 PF15753.5 PIK52468.1 - 0.046 13.8 2.8 0.049 13.8 2.8 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 CAML PF14963.6 PIK52468.1 - 0.24 11.5 4.2 0.26 11.4 4.2 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand zf-CCHC_5 PF14787.6 PIK52469.1 - 0.00086 19.0 5.4 0.0019 17.9 5.4 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Retrotrans_gag PF03732.17 PIK52469.1 - 0.0094 16.2 3.8 0.017 15.4 0.8 2.8 3 1 0 3 3 3 1 Retrotransposon gag protein zf-CCHC PF00098.23 PIK52469.1 - 0.013 15.5 4.1 0.013 15.5 4.1 2.9 3 0 0 3 3 3 0 Zinc knuckle FIBP PF05427.11 PIK52469.1 - 0.014 14.7 0.4 0.023 14.0 0.4 1.3 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) APCDDC PF14921.6 PIK52469.1 - 0.014 14.9 1.9 0.021 14.3 1.3 1.5 1 1 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 Retrotran_gag_2 PF14223.6 PIK52469.1 - 0.11 12.2 2.3 0.11 12.1 0.4 1.9 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type zf-CCHC_2 PF13696.6 PIK52469.1 - 0.97 9.3 4.3 2.2 8.2 4.3 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK52469.1 - 2.3 8.0 6.7 3.8 7.3 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK52470.1 - 4.6e-32 110.0 0.0 1.1e-31 108.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52470.1 - 1.4e-27 96.0 0.0 2.9e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52470.1 - 5.4e-07 29.3 0.4 3.7e-06 26.6 0.2 2.2 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK52471.1 - 2.1e-19 69.9 0.0 3.6e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52471.1 - 7.7e-17 61.2 0.4 1.4e-16 60.4 0.4 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK52471.1 - 1.6e-06 28.2 0.1 2.7e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK52471.1 - 0.0032 17.2 0.1 0.0089 15.8 0.1 1.7 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK52472.1 - 6e-54 182.9 0.1 6e-54 182.9 0.1 2.2 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Stathmin PF00836.19 PIK52472.1 - 0.017 15.1 3.2 0.042 13.8 3.2 1.6 1 0 0 1 1 1 0 Stathmin family Phage_lysis PF03245.13 PIK52472.1 - 0.18 12.0 2.1 0.87 9.7 2.3 2.0 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein RRP7 PF12923.7 PIK52472.1 - 0.27 11.4 0.0 0.27 11.4 0.0 2.7 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF4890 PF16231.5 PIK52472.1 - 0.51 10.8 6.5 0.079 13.5 2.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4890) POTRA_1 PF08478.10 PIK52472.1 - 0.57 10.5 5.1 9.6 6.6 0.1 3.6 2 1 1 3 3 3 0 POTRA domain, FtsQ-type Peptidase_M10 PF00413.24 PIK52473.1 - 2.1e-45 154.4 0.1 4.5e-45 153.3 0.0 1.6 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.19 PIK52473.1 - 4.4e-28 97.0 9.5 4.3e-12 45.8 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 PIK52473.1 - 0.00019 21.6 0.0 0.00048 20.3 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 PIK52473.1 - 0.0029 17.3 0.1 0.0049 16.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 PIK52473.1 - 0.015 15.8 1.0 0.032 14.7 0.5 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK52473.1 - 0.036 14.2 0.1 0.07 13.3 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.5 PIK52473.1 - 0.038 13.2 0.2 0.081 12.1 0.0 1.5 2 0 0 2 2 2 0 Met-zincin Metallopep PF12044.8 PIK52473.1 - 0.095 11.3 0.1 0.15 10.6 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family UNC-50 PF05216.13 PIK52474.1 - 2.4e-71 239.8 13.3 2.7e-71 239.7 13.3 1.0 1 0 0 1 1 1 1 UNC-50 family TMEM144 PF07857.12 PIK52475.1 - 6.7e-103 344.2 8.5 8.9e-103 343.8 8.5 1.2 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 PIK52475.1 - 5.9e-10 38.9 11.2 2e-08 33.9 6.1 2.3 2 0 0 2 2 2 2 Sugar transport protein DMT_YdcZ PF04657.13 PIK52475.1 - 0.0074 16.6 4.2 0.0074 16.6 4.2 3.3 2 2 1 3 3 3 1 Putative inner membrane exporter, YdcZ RVT_1 PF00078.27 PIK52476.1 - 1.2e-17 64.2 0.0 2.5e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PGC7_Stella PF15549.6 PIK52476.1 - 0.16 11.9 0.3 0.29 11.1 0.3 1.3 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain AAA_33 PF13671.6 PIK52477.1 - 2.4e-05 24.5 0.1 7.4e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain CUE PF02845.16 PIK52478.1 - 5e-11 42.1 0.1 9e-07 28.5 0.0 2.3 2 0 0 2 2 2 2 CUE domain DMA PF03474.14 PIK52478.1 - 4.8e-06 26.1 0.1 1.1e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 DMRTA motif DUF1771 PF08590.10 PIK52479.1 - 1e-20 73.8 11.6 1e-20 73.8 11.6 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF1771) Smr PF01713.21 PIK52479.1 - 7.8e-08 32.6 0.0 2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Smr domain Pyridox_oxase_2 PF12766.7 PIK52479.1 - 0.2 12.3 6.2 0.18 12.4 2.7 2.7 1 1 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Arfaptin PF06456.13 PIK52480.1 - 3.1e-73 246.1 12.2 4e-73 245.8 12.2 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR_3 PF16746.5 PIK52480.1 - 0.79 9.4 10.4 1.4 8.6 10.4 1.4 1 0 0 1 1 1 0 BAR domain of APPL family ING PF12998.7 PIK52481.1 - 2e-24 86.1 4.0 2e-24 86.1 4.0 2.1 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 PIK52481.1 - 2.3e-05 24.2 7.0 4.7e-05 23.2 7.0 1.6 1 0 0 1 1 1 1 PHD-finger Endostatin PF06482.11 PIK52481.1 - 0.32 10.4 4.9 0.36 10.3 4.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin zf-HC5HC2H PF13771.6 PIK52481.1 - 0.33 11.2 3.8 0.99 9.7 3.4 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain RRN3 PF05327.11 PIK52481.1 - 0.46 9.0 11.6 0.29 9.6 9.6 1.4 1 1 1 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 MCM_bind PF09739.9 PIK52481.1 - 0.95 7.8 11.3 1.7 7.0 11.3 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 PIK52481.1 - 3.2 5.9 11.6 3.6 5.8 11.6 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 PIK52481.1 - 4 7.2 15.1 5 6.9 15.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 PIK52481.1 - 7.9 5.1 11.0 12 4.5 11.0 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 PIK52481.1 - 9.2 5.4 7.2 11 5.1 7.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-BED PF02892.15 PIK52482.1 - 9.2e-05 22.4 0.5 0.0002 21.3 0.5 1.6 1 0 0 1 1 1 1 BED zinc finger DUF659 PF04937.15 PIK52482.1 - 0.0016 18.3 0.1 0.026 14.4 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) zf-C2H2_4 PF13894.6 PIK52484.1 - 9.3e-16 57.2 101.3 0.019 15.7 0.3 14.7 15 0 0 15 15 14 9 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK52484.1 - 4e-12 45.9 99.5 0.0034 17.7 0.4 13.8 14 0 0 14 14 14 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK52484.1 - 1.5e-05 25.2 94.3 0.00044 20.6 0.1 15.7 17 1 0 17 17 17 5 Zinc-finger double domain zf-H2C2_5 PF13909.6 PIK52484.1 - 0.00026 20.7 0.4 0.00026 20.7 0.4 11.3 14 0 0 14 14 12 3 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 PIK52484.1 - 0.0025 18.5 33.8 0.78 10.4 0.4 7.6 4 2 2 6 6 6 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 PIK52484.1 - 0.0065 16.2 0.0 0.0065 16.2 0.0 8.3 9 0 0 9 9 9 2 zinc-finger C2H2-type zf-met PF12874.7 PIK52484.1 - 0.082 13.3 0.0 0.082 13.3 0.0 9.1 10 0 0 10 10 9 0 Zinc-finger of C2H2 type Spt46 PF17734.1 PIK52484.1 - 0.16 11.7 0.0 0.16 11.7 0.0 4.0 4 2 2 6 6 6 0 Spermatogenesis-associated protein 46 zf-C2H2_12 PF18658.1 PIK52484.1 - 0.23 11.1 17.6 1.4 8.6 0.1 6.3 7 0 0 7 7 7 0 Zinc-finger C2H2-type zf-C2HE PF16278.5 PIK52484.1 - 2.2 8.8 0.0 2.2 8.8 0.0 10.3 7 3 4 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_8 PF15909.5 PIK52484.1 - 4.4 7.7 21.3 9.1 6.7 0.2 6.0 4 1 2 6 6 6 0 C2H2-type zinc ribbon MamL-1 PF09596.10 PIK52485.1 - 0.071 13.4 9.9 0.2 12.0 9.9 1.8 1 0 0 1 1 1 0 MamL-1 domain Kelch_1 PF01344.25 PIK52486.1 - 3.7e-56 186.5 3.9 3.4e-13 48.9 0.1 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 PIK52486.1 - 4.1e-32 109.4 3.0 2.5e-09 37.1 0.0 5.3 2 2 3 5 5 5 4 Kelch motif BACK PF07707.15 PIK52486.1 - 2.6e-31 107.8 0.3 2.6e-31 107.8 0.3 2.1 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 PIK52486.1 - 6.6e-25 87.5 2.5 1.1e-24 86.8 0.8 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 PIK52486.1 - 4.4e-20 70.8 5.1 0.00015 21.6 0.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 PIK52486.1 - 1.7e-11 44.0 1.5 1.8e-05 24.7 0.0 4.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK52486.1 - 9.3e-08 32.2 0.2 0.28 11.5 0.0 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK52486.1 - 0.00053 19.9 0.9 2.5 8.2 0.0 4.0 4 0 0 4 4 4 2 Kelch motif DEK_C PF08766.11 PIK52486.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 DEK C terminal domain DUF4594 PF15266.6 PIK52487.1 - 4.3e-26 92.4 27.2 4.3e-26 92.4 27.2 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4594) PDZ PF00595.24 PIK52487.1 - 7.8e-10 39.0 0.1 2e-09 37.7 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK52487.1 - 0.00027 20.7 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF5320 PF17253.2 PIK52487.1 - 0.0032 18.5 1.3 0.0032 18.5 1.3 4.7 4 0 0 4 4 4 1 Family of unknown function (DUF5320) DUF2098 PF09871.9 PIK52487.1 - 6.9 7.1 6.8 2 8.8 1.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) DUF4209 PF13910.6 PIK52488.1 - 1.7e-15 57.0 0.1 3.7e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) DASH_Dam1 PF08653.10 PIK52488.1 - 0.12 12.2 0.0 0.37 10.6 0.0 1.9 1 0 0 1 1 1 0 DASH complex subunit Dam1 zf-RING_UBOX PF13445.6 PIK52489.1 - 4.5e-07 29.8 5.1 4.5e-07 29.8 5.1 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK52489.1 - 2.4e-05 24.4 13.0 2.4e-05 24.4 13.0 3.9 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK52489.1 - 3.3e-05 24.0 23.7 7.7e-05 22.8 7.6 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-C3HC4 PF00097.25 PIK52489.1 - 7.2e-05 22.6 12.0 7.2e-05 22.6 12.0 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK52489.1 - 0.00016 21.9 12.2 0.00016 21.9 12.2 4.2 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK52489.1 - 0.00072 19.3 13.3 0.00072 19.3 13.3 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK52489.1 - 0.0016 18.2 11.7 0.0016 18.2 11.7 4.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Nucleoside_tran PF01733.18 PIK52489.1 - 0.011 15.2 0.4 0.011 15.2 0.4 1.5 2 0 0 2 2 2 0 Nucleoside transporter DUF383 PF04063.14 PIK52489.1 - 0.22 11.2 2.8 0.21 11.2 1.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF383) CorA PF01544.18 PIK52489.1 - 0.29 10.4 2.6 0.5 9.6 2.6 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc7 PF08317.11 PIK52489.1 - 0.77 8.6 9.0 1.4 7.7 9.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein BTB PF00651.31 PIK52490.1 - 2.2e-07 31.1 0.1 2.7e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain LIN52 PF10044.9 PIK52491.1 - 5e-23 81.6 0.0 5.4e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 Retinal tissue protein CENP-M PF11111.8 PIK52492.1 - 0.025 13.8 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) Astro_capsid_p PF12226.8 PIK52492.1 - 0.35 10.0 7.0 0.53 9.4 7.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Thioredoxin_6 PF13848.6 PIK52493.1 - 5.1e-14 52.6 0.0 1.2e-13 51.4 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 PIK52493.1 - 4.6e-05 23.4 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Glyco_hydro_1 PF00232.18 PIK52494.1 - 3.9e-61 206.9 0.1 2.9e-44 151.3 0.1 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 1 Glyco_hydro_1 PF00232.18 PIK52495.1 - 9.6e-49 166.0 0.1 1.1e-48 165.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Orf78 PF06024.12 PIK52495.1 - 0.0007 19.9 0.5 0.001 19.3 0.5 1.2 1 0 0 1 1 1 1 Orf78 (ac78) BUD22 PF09073.10 PIK52495.1 - 0.0013 18.1 1.0 0.0013 18.1 1.0 1.0 1 0 0 1 1 1 1 BUD22 RRN3 PF05327.11 PIK52495.1 - 0.0014 17.3 5.9 0.0014 17.3 5.9 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF3377 PF11857.8 PIK52495.1 - 0.011 15.6 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF5383 PF17355.2 PIK52495.1 - 0.055 13.8 0.1 0.084 13.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DNA_pol_phi PF04931.13 PIK52495.1 - 0.17 10.0 28.6 0.2 9.7 28.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi GCIP PF13324.6 PIK52495.1 - 0.54 9.8 15.7 0.79 9.3 15.7 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Glyco_hydro_1 PF00232.18 PIK52496.1 - 7.1e-72 242.3 1.6 7.9e-72 242.1 1.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 PIK52496.1 - 0.048 12.8 0.1 0.072 12.2 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 Glyco_hydro_1 PF00232.18 PIK52497.1 - 1.2e-175 584.3 9.4 1.4e-175 584.1 9.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 PIK52497.1 - 0.003 16.8 0.5 0.66 9.1 0.1 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 10 Glyco_hydro_1 PF00232.18 PIK52498.1 - 9.1e-160 532.0 4.7 1e-159 531.8 4.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 PIK52498.1 - 0.053 12.7 0.2 0.11 11.6 0.2 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 MBOAT PF03062.19 PIK52499.1 - 5.3e-22 78.7 16.5 5.3e-22 78.7 16.5 1.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family CSN8_PSD8_EIF3K PF10075.9 PIK52500.1 - 1.1e-11 44.8 0.0 2.9e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family AAA PF00004.29 PIK52501.1 - 3.4e-28 98.7 0.0 7.7e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK52501.1 - 9.4e-12 44.5 0.3 2.3e-11 43.3 0.3 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 PIK52501.1 - 1.3e-07 31.5 0.0 2.8e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 PIK52501.1 - 1.8e-07 31.7 0.1 0.00014 22.3 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 PIK52501.1 - 8.8e-06 25.6 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK52501.1 - 1.4e-05 25.1 0.0 0.00085 19.3 0.0 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 PIK52501.1 - 1.8e-05 25.0 0.0 6.2e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK52501.1 - 2.4e-05 24.6 0.1 0.0014 18.9 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 PIK52501.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 PIK52501.1 - 0.0031 17.7 0.0 0.0089 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 PIK52501.1 - 0.0047 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 PIK52501.1 - 0.0051 17.4 0.1 0.042 14.4 0.0 2.4 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 PIK52501.1 - 0.0053 15.9 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 PIK52501.1 - 0.0057 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 PIK52501.1 - 0.0078 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK52501.1 - 0.0079 16.6 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.11 PIK52501.1 - 0.009 15.9 0.0 0.031 14.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 PIK52501.1 - 0.0096 15.7 0.5 0.13 12.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 PIK52501.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 PIK52501.1 - 0.017 15.1 0.3 0.38 10.6 0.0 3.2 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 PIK52501.1 - 0.017 14.4 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 PIK52501.1 - 0.019 14.7 0.0 0.098 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Occludin_ELL PF07303.13 PIK52501.1 - 0.022 15.5 0.9 0.045 14.5 0.9 1.5 1 0 0 1 1 1 0 Occludin homology domain Prot_ATP_OB_N PF17758.1 PIK52501.1 - 0.024 14.3 0.1 0.058 13.1 0.1 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Thymidylate_kin PF02223.17 PIK52501.1 - 0.036 13.8 0.1 4.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase AAA_25 PF13481.6 PIK52501.1 - 0.042 13.4 0.2 0.35 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 PIK52501.1 - 0.043 13.5 0.3 0.15 11.8 0.0 2.0 3 0 0 3 3 2 0 AAA domain GAS PF13851.6 PIK52501.1 - 0.046 13.1 4.5 0.084 12.2 4.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ThiD2 PF17792.1 PIK52501.1 - 0.06 13.8 0.5 0.36 11.3 0.3 2.3 2 0 0 2 2 2 0 ThiD2 family ATPase PF06745.13 PIK52501.1 - 0.085 12.2 0.1 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 PIK52501.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 PIK52501.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 PIK52501.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 PIK52501.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_13 PF13166.6 PIK52501.1 - 0.14 10.8 0.8 8.5 4.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Neur PF00064.18 PIK52501.1 - 0.2 10.4 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Neuraminidase AAA_23 PF13476.6 PIK52501.1 - 0.35 11.3 4.6 49 4.3 5.9 2.4 2 0 0 2 2 2 0 AAA domain M PF02370.16 PIK52501.1 - 8.8 7.3 14.0 6.5 7.7 1.6 3.8 2 1 1 3 3 3 0 M protein repeat Pkinase PF00069.25 PIK52502.1 - 3e-65 220.2 0.0 4.4e-65 219.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52502.1 - 4.5e-36 124.5 0.0 6.9e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 PIK52502.1 - 1.6e-32 111.1 23.2 9.3e-17 60.7 5.8 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 PIK52502.1 - 2.5e-18 66.2 0.5 5.3e-18 65.2 0.5 1.5 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 PIK52502.1 - 2.4e-10 40.9 0.5 6e-10 39.7 0.5 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.16 PIK52502.1 - 0.00035 20.8 15.4 0.032 14.5 4.8 2.7 2 0 0 2 2 2 2 C1 domain Haspin_kinase PF12330.8 PIK52502.1 - 0.0027 16.7 0.0 0.0047 15.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK52502.1 - 0.013 14.8 0.0 0.045 13.1 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 PIK52502.1 - 0.081 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FYVE_2 PF02318.16 PIK52502.1 - 4.3 7.6 18.5 1.3 9.2 3.8 3.7 3 1 0 4 4 4 0 FYVE-type zinc finger PHD PF00628.29 PIK52502.1 - 4.5 7.3 19.6 3.2 7.7 5.0 2.6 2 0 0 2 2 2 0 PHD-finger DZR PF12773.7 PIK52502.1 - 6.8 6.8 15.7 1.7 8.8 4.8 2.8 2 0 0 2 2 2 0 Double zinc ribbon Fe-S_biosyn PF01521.20 PIK52503.1 - 6.4e-08 32.8 0.0 8.4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis ANAPC4_WD40 PF12894.7 PIK52504.1 - 3.5e-06 27.2 0.0 0.14 12.5 0.0 3.8 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK52504.1 - 0.00053 20.7 16.3 0.0017 19.1 0.4 5.5 4 1 0 4 4 4 2 WD domain, G-beta repeat PRTase_3 PF15610.6 PIK52504.1 - 0.077 12.2 0.0 0.21 10.8 0.0 1.6 2 0 0 2 2 2 0 PRTase ComF-like Guanylate_kin PF00625.21 PIK52505.1 - 5e-39 133.9 0.0 7.8e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 PIK52505.1 - 3e-12 46.7 1.3 3e-12 46.7 1.3 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK52505.1 - 9.3e-11 41.4 0.1 2.4e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 PIK52505.1 - 1.4e-08 34.3 0.0 3.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK52505.1 - 9.7e-08 31.5 0.4 3.8e-07 29.6 0.4 2.1 1 1 0 1 1 1 1 SH3 domain PDZ_2 PF13180.6 PIK52505.1 - 0.00068 19.9 0.3 0.0015 18.8 0.3 1.5 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 PIK52505.1 - 0.0022 17.8 1.9 0.0042 16.9 0.1 2.4 3 0 0 3 3 3 1 Variant SH3 domain SPT6_acidic PF14632.6 PIK52505.1 - 1.2 9.8 9.1 0.13 12.9 3.8 2.1 2 0 0 2 2 2 0 Acidic N-terminal SPT6 L27_N PF09060.10 PIK52506.1 - 2e-13 50.2 7.3 3.5e-13 49.4 7.3 1.4 1 0 0 1 1 1 1 L27_N L27 PF02828.16 PIK52506.1 - 2.8e-10 39.8 4.8 3.3e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 L27 domain TetR_C_19 PF17924.1 PIK52506.1 - 0.15 12.6 0.1 0.15 12.6 0.1 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PDZ PF00595.24 PIK52507.1 - 2e-14 53.7 0.0 4.2e-14 52.6 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK52507.1 - 2.2e-11 43.4 0.0 3.7e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK52507.1 - 3e-07 30.7 0.0 4.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_4 PF17816.1 PIK52507.1 - 0.069 13.5 0.1 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 PDZ domain Ubiquitin_2 PF14560.6 PIK52508.1 - 1.2e-28 99.3 0.1 2.2e-28 98.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.25 PIK52508.1 - 3.9e-24 84.5 2.9 5.8e-24 83.9 2.0 1.8 2 0 0 2 2 2 1 CAP-Gly domain DUF4107 PF13389.6 PIK52508.1 - 0.0073 16.5 0.2 0.015 15.4 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4107) ubiquitin PF00240.23 PIK52508.1 - 0.034 13.9 0.5 0.2 11.4 0.1 2.4 2 1 0 2 2 2 0 Ubiquitin family RSV_NS2 PF03113.14 PIK52508.1 - 0.17 11.9 0.1 0.41 10.7 0.1 1.6 1 0 0 1 1 1 0 Respiratory synctial virus non-structural protein NS2 VGCC_beta4Aa_N PF12052.8 PIK52508.1 - 0.48 10.6 3.3 1.1 9.4 3.3 1.5 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal WD40 PF00400.32 PIK52509.1 - 2.1e-24 85.3 2.6 9.2e-09 35.8 0.1 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Striatin PF08232.12 PIK52509.1 - 5.6e-05 23.8 0.1 0.00016 22.3 0.1 1.8 1 0 0 1 1 1 1 Striatin family ANAPC4_WD40 PF12894.7 PIK52509.1 - 0.00013 22.2 0.1 0.22 11.9 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Clat_adaptor_s PF01217.20 PIK52510.1 - 6.9e-23 81.1 1.6 8e-23 81.0 1.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain EBV-NA3 PF05009.12 PIK52510.1 - 0.16 11.5 0.7 0.21 11.1 0.5 1.3 1 1 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) CAP_GLY PF01302.25 PIK52511.1 - 1.8e-19 69.5 0.1 3.1e-19 68.8 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 PIK52511.1 - 8.2e-12 45.1 28.3 0.0013 19.1 0.5 6.0 4 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK52511.1 - 1.6e-11 43.8 21.2 0.023 14.4 1.7 5.7 4 2 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 PIK52511.1 - 5.6e-09 35.7 10.1 1.9e-06 27.5 0.3 3.2 1 1 2 3 3 3 3 Leucine-rich repeat Med22 PF06179.12 PIK52511.1 - 0.092 13.0 1.7 1.8 8.8 0.6 2.7 2 1 1 3 3 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex LRR_1 PF00560.33 PIK52511.1 - 1.2 10.0 18.4 22 6.1 0.2 7.1 7 2 1 8 8 8 0 Leucine Rich Repeat DUF296 PF03479.15 PIK52512.1 - 2.9e-09 37.2 0.2 4e-09 36.8 0.2 1.2 1 0 0 1 1 1 1 Plants and Prokaryotes Conserved (PCC) domain Fcf1 PF04900.12 PIK52513.1 - 1.6e-27 95.8 0.5 2.4e-27 95.2 0.2 1.4 1 1 1 2 2 2 1 Fcf1 PIN_9 PF18477.1 PIK52513.1 - 1.1e-05 25.8 0.0 1.3e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 PIN like domain HECT PF00632.25 PIK52514.1 - 9.3e-73 245.4 0.7 9.3e-73 245.4 0.7 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.19 PIK52514.1 - 1.7e-12 48.1 1.1 3.3e-07 31.1 0.1 2.6 2 0 0 2 2 2 2 Filamin/ABP280 repeat GIT_CC PF16559.5 PIK52514.1 - 0.042 13.7 1.8 6.7 6.7 0.1 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Syntaxin-6_N PF09177.11 PIK52514.1 - 0.15 12.7 0.5 0.46 11.1 0.5 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal ARA70 PF12489.8 PIK52515.1 - 0.071 13.3 0.1 0.071 13.3 0.1 2.8 3 0 0 3 3 3 0 Nuclear coactivator LRR_6 PF13516.6 PIK52516.1 - 1.3e-31 105.9 9.0 1.5e-05 24.6 0.0 9.7 9 0 0 9 9 9 8 Leucine Rich repeat EF-hand_6 PF13405.6 PIK52516.1 - 6.6e-08 31.9 2.2 0.0082 16.0 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 PIK52516.1 - 8.2e-08 31.3 1.1 0.003 17.0 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK52516.1 - 1.6e-07 31.7 0.9 4.6e-07 30.2 0.3 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK52516.1 - 9.7e-05 21.7 1.6 0.16 11.5 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK52516.1 - 9.9e-05 22.1 0.2 0.00034 20.4 0.1 2.0 1 1 0 1 1 1 1 EF-hand domain pair LRR_1 PF00560.33 PIK52516.1 - 0.00026 21.1 0.1 9.9 7.2 0.0 6.7 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_2 PF07723.13 PIK52516.1 - 0.0038 17.8 3.5 12 6.7 0.0 4.4 5 0 0 5 5 5 2 Leucine Rich Repeat COPI_C PF06957.11 PIK52516.1 - 0.097 11.4 0.4 0.15 10.8 0.4 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus LRR_4 PF12799.7 PIK52516.1 - 0.19 12.2 14.3 3.6 8.1 0.2 6.3 5 2 1 7 7 7 0 Leucine Rich repeats (2 copies) Arf PF00025.21 PIK52517.1 - 5e-72 241.0 0.2 5.7e-72 240.8 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK52517.1 - 6.9e-12 45.6 0.0 1e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK52517.1 - 1.3e-11 44.3 2.1 5.6e-06 25.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 PIK52517.1 - 1.2e-10 41.1 0.0 1.7e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK52517.1 - 3.1e-10 39.9 0.0 3.7e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 PIK52517.1 - 5.7e-08 32.4 0.0 6.8e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK52517.1 - 1.8e-05 24.8 0.0 3.5e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK52517.1 - 0.0079 15.8 0.0 0.023 14.2 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 PIK52517.1 - 0.01 15.3 0.2 0.015 14.7 0.2 1.2 1 0 0 1 1 1 0 Bacterial TniB protein tRNA-synt_1b PF00579.25 PIK52518.1 - 4.1e-21 75.6 0.0 1.2e-20 74.0 0.0 1.8 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) Pkinase PF00069.25 PIK52519.1 - 1.8e-52 178.3 0.0 3.2e-52 177.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52519.1 - 3e-35 121.8 0.0 4.8e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK52519.1 - 3.5e-05 23.3 0.0 0.00012 21.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 PIK52519.1 - 0.0026 16.8 0.3 0.0026 16.8 0.3 1.7 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 PIK52519.1 - 0.0058 16.6 1.2 0.016 15.1 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Ank_4 PF13637.6 PIK52520.1 - 1.2e-16 60.8 0.6 1.8e-12 47.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK52520.1 - 5.2e-12 46.2 0.9 8.7e-12 45.5 0.9 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK52520.1 - 1.1e-11 44.7 3.6 1.1e-09 38.3 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK52520.1 - 7.7e-11 41.9 5.7 1.8e-05 25.0 0.3 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 PIK52520.1 - 2.7e-09 36.5 1.1 0.00012 22.2 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat HTH_Mga PF08280.11 PIK52520.1 - 0.043 13.8 0.1 0.075 13.1 0.1 1.4 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Sec10 PF07393.11 PIK52521.1 - 1.5e-111 374.1 13.2 2.1e-57 195.1 6.7 5.3 2 2 2 4 4 4 4 Exocyst complex component Sec10 Jnk-SapK_ap_N PF09744.9 PIK52521.1 - 0.00012 22.4 0.5 0.00012 22.4 0.5 2.4 3 0 0 3 3 2 1 JNK_SAPK-associated protein-1 DUF812 PF05667.11 PIK52521.1 - 0.009 15.0 1.4 0.009 15.0 1.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF812) Baculo_PEP_C PF04513.12 PIK52521.1 - 0.02 14.9 1.6 0.07 13.2 0.0 2.7 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps53_N PF04100.12 PIK52521.1 - 0.036 13.1 9.4 2.6 6.9 0.1 3.2 3 0 0 3 3 3 0 Vps53-like, N-terminal CorA PF01544.18 PIK52521.1 - 0.053 12.8 0.2 0.053 12.8 0.2 1.9 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HIP1_clath_bdg PF16515.5 PIK52521.1 - 0.072 13.7 6.4 0.04 14.5 1.9 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BLOC1_2 PF10046.9 PIK52521.1 - 0.09 13.1 10.8 0.15 12.4 0.2 4.2 3 1 1 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SPARC_Ca_bdg PF10591.9 PIK52521.1 - 0.12 12.7 4.4 5.5 7.3 0.1 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region LUC7 PF03194.15 PIK52521.1 - 0.15 11.7 8.4 0.14 11.8 1.1 2.7 3 0 0 3 3 3 0 LUC7 N_terminus DUF2203 PF09969.9 PIK52521.1 - 0.16 12.7 1.1 3.6 8.3 0.3 3.0 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2203) TMF_DNA_bd PF12329.8 PIK52521.1 - 0.16 11.9 3.6 4.9 7.2 3.8 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.11 PIK52521.1 - 0.18 12.2 2.5 24 5.4 0.2 3.3 2 1 1 3 3 2 0 Flagella accessory protein C (FlaC) GrpE PF01025.19 PIK52521.1 - 0.37 10.4 4.3 1.5 8.5 0.8 3.1 2 1 0 2 2 2 0 GrpE Phage_Mu_Gam PF07352.12 PIK52521.1 - 1.1 9.2 5.9 0.26 11.2 1.2 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein DUF16 PF01519.16 PIK52521.1 - 1.2 9.7 12.3 0.14 12.7 1.0 3.3 4 0 0 4 4 3 0 Protein of unknown function DUF16 DUF1664 PF07889.12 PIK52521.1 - 1.2 9.2 7.3 1.4 8.9 3.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) GldM_N PF12081.8 PIK52521.1 - 1.4 8.9 6.4 1.7 8.7 4.5 2.2 2 0 0 2 2 2 0 GldM N-terminal domain Snf7 PF03357.21 PIK52521.1 - 1.7 8.2 9.0 0.37 10.4 1.8 2.9 2 1 1 3 3 3 0 Snf7 Fib_alpha PF08702.10 PIK52521.1 - 2.5 8.3 8.2 0.83 9.8 2.1 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TipAS PF07739.13 PIK52521.1 - 2.8 8.5 5.1 12 6.5 1.2 3.3 3 1 0 3 3 3 0 TipAS antibiotic-recognition domain THOC7 PF05615.13 PIK52521.1 - 3.9 7.8 8.5 1.3 9.3 2.6 2.9 2 2 0 2 2 2 0 Tho complex subunit 7 CLZ PF16526.5 PIK52521.1 - 5 7.6 9.1 1.1 9.6 2.2 3.3 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tho2 PF11262.8 PIK52521.1 - 6.5 5.9 11.3 0.69 9.1 2.4 3.1 4 0 0 4 4 4 0 Transcription factor/nuclear export subunit protein 2 XhlA PF10779.9 PIK52521.1 - 7.8 6.8 8.9 4.2 7.6 0.6 3.1 2 1 1 3 3 2 0 Haemolysin XhlA Pinin_SDK_memA PF04696.13 PIK52521.1 - 8.2 6.5 10.0 0.55 10.3 3.1 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Glutaredoxin PF00462.24 PIK52522.1 - 2.2e-17 63.0 0.0 4e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Pro_racemase PF05544.11 PIK52523.1 - 1.2e-100 336.7 0.7 1.4e-100 336.5 0.7 1.0 1 0 0 1 1 1 1 Proline racemase DUF2961 PF11175.8 PIK52523.1 - 0.05 13.2 0.1 0.085 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) DAP_epimerase PF01678.19 PIK52523.1 - 0.063 13.4 0.0 0.6 10.3 0.0 2.2 2 0 0 2 2 2 0 Diaminopimelate epimerase FoP_duplication PF13865.6 PIK52524.1 - 0.92 10.1 8.1 1.7 9.2 8.1 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 ELO PF01151.18 PIK52526.1 - 6.1e-41 140.6 25.2 9e-41 140.0 25.2 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Thioredoxin PF00085.20 PIK52527.1 - 1.3e-56 188.9 1.0 7.8e-32 109.3 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 PIK52527.1 - 4e-34 118.1 4.3 2.7e-28 99.1 9.4 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK52527.1 - 9.3e-09 35.5 0.3 0.047 14.0 0.0 4.2 4 1 1 5 5 5 2 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK52527.1 - 5.9e-08 33.1 1.6 0.00039 20.8 0.0 3.6 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 PIK52527.1 - 1.5e-07 31.5 0.0 0.025 14.7 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 PIK52527.1 - 6.7e-06 26.0 0.5 0.052 13.5 0.0 3.4 3 1 1 4 4 4 2 AhpC/TSA family Redoxin PF08534.10 PIK52527.1 - 0.00066 19.4 0.1 0.56 9.9 0.0 3.3 3 0 0 3 3 3 1 Redoxin OST3_OST6 PF04756.13 PIK52527.1 - 0.005 16.2 3.3 0.13 11.5 0.0 3.4 3 1 1 4 4 4 1 OST3 / OST6 family, transporter family Thioredoxin_4 PF13462.6 PIK52527.1 - 0.0082 16.3 2.7 1.2 9.2 0.0 3.4 3 1 0 3 3 3 1 Thioredoxin Inos-1-P_synth PF01658.17 PIK52527.1 - 0.025 14.8 0.0 0.68 10.2 0.0 2.8 3 0 0 3 3 3 0 Myo-inositol-1-phosphate synthase HyaE PF07449.11 PIK52527.1 - 0.11 12.5 0.0 9.6 6.2 0.0 2.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF3314 PF11771.8 PIK52528.1 - 3 8.0 6.3 4.7 7.3 5.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3314) Borrelia_P83 PF05262.11 PIK52528.1 - 6 5.2 34.3 7.1 5.0 34.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein zf-H2C2_2 PF13465.6 PIK52529.1 - 1.3e-11 44.3 45.4 1.3e-07 31.7 2.0 8.0 8 0 0 8 8 8 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52529.1 - 5.5e-08 32.8 57.1 6e-05 23.3 1.6 7.6 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52529.1 - 1.9e-05 25.1 50.7 0.0077 17.0 0.7 7.6 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2HC_2 PF13913.6 PIK52529.1 - 0.019 14.9 0.6 0.019 14.9 0.6 5.0 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-RING_7 PF02591.15 PIK52529.1 - 0.95 9.7 3.7 53 4.1 0.1 3.7 3 0 0 3 3 3 0 C4-type zinc ribbon domain Elf1 PF05129.13 PIK52529.1 - 1.3 9.1 21.9 1.8 8.7 1.0 5.2 2 1 1 4 4 4 0 Transcription elongation factor Elf1 like zf-met PF12874.7 PIK52529.1 - 8 7.0 25.1 4.8 7.7 0.1 5.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Aminotran_5 PF00266.19 PIK52530.1 - 2.1e-13 50.0 0.0 2.8e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK52530.1 - 0.0022 17.2 0.1 0.011 15.0 0.1 2.1 2 1 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 PIK52530.1 - 0.18 10.3 0.0 0.27 9.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme EAL PF00563.20 PIK52530.1 - 0.18 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 EAL domain YchF-GTPase_C PF06071.13 PIK52531.1 - 5.9e-40 135.3 1.4 1.1e-39 134.5 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 PIK52531.1 - 3.1e-21 75.6 0.0 1.6e-20 73.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK52531.1 - 2.1e-06 27.4 0.0 4.5e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 PIK52531.1 - 0.0033 17.4 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 TGS domain MeaB PF03308.16 PIK52531.1 - 0.0063 15.5 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 PIK52531.1 - 0.052 13.8 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 PIK52531.1 - 0.055 14.0 0.0 0.67 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain zf-H2C2_2 PF13465.6 PIK52532.1 - 2e-13 50.1 8.4 1.8e-07 31.2 2.7 4.6 5 1 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52532.1 - 1.5e-08 34.7 39.6 3.5e-05 24.0 3.3 4.3 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52532.1 - 3.9e-05 24.1 8.5 0.00072 20.2 1.6 4.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK52532.1 - 0.00097 19.1 14.9 0.016 15.2 1.2 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK52532.1 - 0.024 14.9 6.5 0.028 14.7 4.2 2.4 1 1 0 1 1 1 0 C2H2-type zinc ribbon TcfC PF16967.5 PIK52532.1 - 0.034 13.6 0.1 0.19 11.2 0.1 2.3 1 0 0 1 1 1 0 E-set like domain DNA_primase_S PF01896.19 PIK52533.1 - 1.4e-55 188.0 0.8 2.3e-55 187.3 0.8 1.3 1 0 0 1 1 1 1 DNA primase small subunit Exo70 PF03081.15 PIK52533.1 - 0.13 11.3 0.2 0.6 9.1 0.3 1.9 1 1 1 2 2 2 0 Exo70 exocyst complex subunit DUF535 PF04393.13 PIK52534.1 - 0.021 14.1 0.2 0.027 13.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF535) Yippee-Mis18 PF03226.14 PIK52534.1 - 0.074 13.3 0.1 0.13 12.5 0.1 1.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly N-SET PF11764.8 PIK52534.1 - 0.19 11.8 2.7 0.13 12.4 1.2 1.4 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component N Glyco_hydro_4C PF11975.8 PIK52534.1 - 0.31 11.1 3.1 3.5 7.6 0.2 2.0 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase C-terminal domain PP2C PF00481.21 PIK52535.1 - 7.2e-33 114.3 1.8 8.2e-31 107.6 0.1 3.0 3 0 0 3 3 3 2 Protein phosphatase 2C DUF1347 PF07079.11 PIK52535.1 - 0.067 11.8 0.1 0.097 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) Ras PF00071.22 PIK52536.1 - 3.2e-59 199.2 0.1 4e-59 198.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK52536.1 - 1.1e-34 119.3 0.0 2.2e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK52536.1 - 2.1e-11 43.6 0.0 2.7e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK52536.1 - 0.00013 22.0 0.0 0.00021 21.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK52536.1 - 0.0002 20.9 0.0 0.00044 19.9 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK52536.1 - 0.00068 19.6 0.1 0.55 10.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 PIK52536.1 - 0.0018 17.7 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 PIK52536.1 - 0.013 15.8 0.4 0.026 14.9 0.3 1.5 1 1 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.32 PIK52537.1 - 4.8e-10 38.3 0.4 8.2e-07 28.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK52537.1 - 6.8e-09 35.0 0.3 3.3e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK52537.1 - 1.2e-08 35.3 0.2 2.5e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK52537.1 - 1.7e-07 30.4 0.0 4.3e-06 26.0 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 PIK52537.1 - 5e-06 26.3 0.2 0.14 12.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair DUF5580 PF17743.1 PIK52537.1 - 6.8e-05 21.6 0.0 0.0001 21.0 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 PIK52537.1 - 0.011 16.1 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PIP5K PF01504.18 PIK52538.1 - 8.4e-32 110.5 5.3 6.3e-25 87.9 0.2 3.0 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Selenoprotein_S PF06936.11 PIK52538.1 - 0.024 14.5 6.0 0.075 12.8 1.1 2.4 2 0 0 2 2 2 0 Selenoprotein S (SelS) 7tm_1 PF00001.21 PIK52539.1 - 1.2e-09 37.9 4.9 1.6e-09 37.5 4.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK52539.1 - 2.8e-06 26.9 2.1 3.4e-06 26.6 2.1 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK52540.1 - 1.4e-30 106.5 25.9 1.4e-30 106.5 25.9 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK52540.1 - 8.3e-10 38.7 20.9 8.3e-10 38.7 20.9 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK52540.1 - 0.00011 21.7 25.4 0.0002 20.8 25.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK52541.1 - 3.3e-36 125.0 15.0 4.1e-36 124.6 15.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK52541.1 - 5.4e-05 23.0 16.8 8.1e-05 22.4 15.8 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK52541.1 - 0.00024 20.6 12.9 0.0026 17.2 12.9 3.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx IgaA PF07095.11 PIK52541.1 - 0.024 12.6 0.0 0.05 11.6 0.0 1.4 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA TMEM154 PF15102.6 PIK52541.1 - 0.055 13.4 0.1 0.6 10.0 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family 7tm_1 PF00001.21 PIK52542.1 - 3.9e-26 92.0 8.3 4.6e-26 91.7 8.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK52542.1 - 2.8e-08 33.7 13.9 4.6e-08 33.0 13.9 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK52542.1 - 6.9e-07 28.9 9.7 9e-07 28.5 9.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK52542.1 - 4.1e-06 26.4 10.8 7.4e-06 25.5 10.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Srg PF02118.21 PIK52542.1 - 0.0028 17.4 14.8 0.011 15.4 14.8 2.1 1 1 0 1 1 1 1 Srg family chemoreceptor DUF4396 PF14342.6 PIK52542.1 - 0.0047 17.3 2.8 0.01 16.2 2.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) zf-C2H2_4 PF13894.6 PIK52543.1 - 6.6e-11 42.1 46.0 0.0033 18.1 0.5 6.4 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK52543.1 - 8.9e-10 38.5 39.9 0.00034 20.9 0.5 7.0 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52543.1 - 2.3e-09 37.2 52.3 0.00023 21.4 0.5 6.6 7 0 0 7 7 6 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK52543.1 - 4.5e-05 23.6 22.5 0.5 10.7 0.6 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 PIK52543.1 - 0.0056 17.0 3.7 0.38 11.1 0.2 2.7 2 0 0 2 2 2 1 zinc-finger-containing domain zf-SNAP50_C PF12251.8 PIK52543.1 - 0.0088 15.7 9.9 0.097 12.3 0.5 2.3 1 1 1 2 2 2 2 snRNA-activating protein of 50kDa MW C terminal Ribosomal_L28 PF00830.19 PIK52543.1 - 0.0095 16.1 1.5 1.3 9.2 0.0 3.0 2 0 0 2 2 2 1 Ribosomal L28 family zf-Di19 PF05605.12 PIK52543.1 - 0.015 15.6 3.1 0.015 15.6 3.1 4.4 3 1 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 PIK52543.1 - 0.041 13.9 0.2 0.041 13.9 0.2 5.9 2 1 4 6 6 6 0 BED zinc finger PyrI_C PF02748.15 PIK52543.1 - 0.044 13.7 17.1 0.063 13.2 0.5 4.4 4 1 1 5 5 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain CpXC PF14353.6 PIK52543.1 - 0.37 10.8 0.1 0.37 10.8 0.1 4.7 2 1 4 6 6 6 0 CpXC protein zf-U1 PF06220.12 PIK52543.1 - 0.65 9.8 7.7 2.9 7.7 0.3 3.4 3 0 0 3 3 3 0 U1 zinc finger Zn-ribbon_8 PF09723.10 PIK52543.1 - 1.5 9.0 16.1 1.1 9.4 2.7 4.5 5 1 0 5 5 5 0 Zinc ribbon domain DUF2180 PF09947.9 PIK52543.1 - 2.7 8.0 9.9 8.1 6.5 0.4 4.1 4 1 1 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) zf-RING_7 PF02591.15 PIK52543.1 - 4.4 7.6 8.9 9.1 6.6 0.2 3.9 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-C2H2_8 PF15909.5 PIK52543.1 - 7.3 7.0 16.8 0.23 11.8 6.3 3.0 1 1 2 3 3 3 0 C2H2-type zinc ribbon Ank_2 PF12796.7 PIK52544.1 - 3.3e-13 50.0 0.2 9.7e-06 26.1 0.1 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK52544.1 - 1.3e-10 41.5 0.0 0.0004 20.9 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK52544.1 - 3.9e-10 39.1 0.1 0.022 15.2 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK52544.1 - 2.4e-07 30.9 0.0 0.012 16.0 0.0 4.6 5 0 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 PIK52544.1 - 8.7e-05 22.7 0.3 0.26 11.7 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF1460 PF07313.12 PIK52544.1 - 0.066 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) Melittin PF01372.17 PIK52544.1 - 0.11 12.5 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 Melittin FYVE_2 PF02318.16 PIK52545.1 - 3.7e-20 72.3 14.9 4.9e-20 71.9 14.9 1.2 1 0 0 1 1 1 1 FYVE-type zinc finger FYVE PF01363.21 PIK52545.1 - 0.055 13.6 14.3 0.098 12.8 14.3 1.4 1 0 0 1 1 1 0 FYVE zinc finger Pkinase_Tyr PF07714.17 PIK52546.1 - 6.6e-11 42.0 0.0 7.3e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52546.1 - 1.5e-09 37.6 0.0 1.9e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Fusion_gly_K PF01621.17 PIK52546.1 - 0.026 13.6 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Cell fusion glycoprotein K ig PF00047.25 PIK52547.1 - 3.1e-07 30.5 3.2 0.019 15.1 0.2 4.7 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52547.1 - 1.1e-06 28.6 3.6 0.00061 19.8 0.3 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK52547.1 - 1.9e-06 28.4 2.8 0.31 11.7 0.2 4.8 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK52547.1 - 4.5e-05 23.6 0.3 0.27 11.4 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin V-set domain AAA_25 PF13481.6 PIK52547.1 - 6.1e-05 22.7 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Ig_2 PF13895.6 PIK52547.1 - 0.0001 22.5 6.4 3.3 8.1 0.4 4.9 3 1 1 4 4 4 1 Immunoglobulin domain NACHT PF05729.12 PIK52547.1 - 0.0034 17.3 0.0 0.0096 15.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Phostensin PF13914.6 PIK52547.1 - 0.027 15.1 0.2 0.055 14.1 0.2 1.5 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region Pet127 PF08634.10 PIK52547.1 - 0.033 13.6 0.6 0.07 12.6 0.2 1.7 2 0 0 2 2 2 0 Mitochondrial protein Pet127 DUF2569 PF10754.9 PIK52547.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Collectrin PF16959.5 PIK52547.1 - 0.2 11.4 1.8 0.86 9.4 1.8 2.1 1 1 0 1 1 1 0 Renal amino acid transporter PIN_5 PF08745.11 PIK52547.1 - 0.26 10.7 3.1 0.44 9.9 0.2 2.6 3 0 0 3 3 3 0 PINc domain ribonuclease V-set PF07686.17 PIK52548.1 - 2.2e-08 34.2 5.0 0.00041 20.5 0.3 3.5 4 0 0 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52548.1 - 6e-06 26.8 5.1 0.053 14.1 0.1 4.0 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK52548.1 - 2.1e-05 24.6 3.5 0.00036 20.7 0.1 3.4 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK52548.1 - 0.00038 20.4 1.7 1.3 9.1 0.0 3.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK52548.1 - 0.0005 20.1 1.0 0.015 15.3 0.2 3.2 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain NHL PF01436.21 PIK52548.1 - 0.0013 18.7 0.0 1.8 8.8 0.0 3.9 3 0 0 3 3 3 1 NHL repeat Ig_2 PF13895.6 PIK52548.1 - 0.0017 18.6 2.3 0.18 12.1 0.2 3.4 2 0 0 2 2 2 1 Immunoglobulin domain PTCRA PF15028.6 PIK52548.1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 Pre-T-cell antigen receptor Izumo-Ig PF16706.5 PIK52548.1 - 0.019 15.0 0.5 0.064 13.3 0.1 2.2 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK52548.1 - 0.023 15.1 0.1 0.12 12.8 0.1 2.2 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK52548.1 - 0.2 11.2 5.9 1.5 8.5 0.6 3.4 2 1 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK52549.1 - 9.5e-06 26.1 3.7 0.011 16.3 0.9 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK52549.1 - 0.0014 18.6 0.1 0.22 11.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK52549.1 - 0.0022 18.0 0.2 0.0069 16.4 0.2 1.8 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK52549.1 - 0.0081 16.5 8.0 0.066 13.5 2.4 2.4 1 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK52549.1 - 0.01 16.0 2.8 0.51 10.5 0.4 2.6 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK52549.1 - 0.05 13.8 6.2 1.2 9.4 0.1 2.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain HisK_sensor PF18698.1 PIK52549.1 - 0.11 12.9 0.3 0.17 12.3 0.3 1.4 1 1 0 1 1 1 0 Histidine kinase sensor domain Exo5 PF09810.9 PIK52550.1 - 0.023 14.2 0.3 0.03 13.8 0.3 1.2 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease Val_tRNA-synt_C PF10458.9 PIK52551.1 - 0.0045 17.2 2.2 0.36 11.1 0.4 2.5 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm HAUS-augmin3 PF14932.6 PIK52551.1 - 0.0052 16.4 2.1 0.0067 16.0 2.1 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Plexin_cytopl PF08337.12 PIK52551.1 - 0.0075 15.0 2.3 0.0081 14.9 2.3 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Spectrin PF00435.21 PIK52551.1 - 0.011 16.2 4.4 0.016 15.7 4.4 1.3 1 0 0 1 1 1 0 Spectrin repeat DegS PF05384.11 PIK52551.1 - 0.018 14.5 2.7 0.018 14.5 2.7 1.6 2 0 0 2 2 2 0 Sensor protein DegS CENP-F_leu_zip PF10473.9 PIK52551.1 - 0.028 14.4 7.7 0.024 14.7 6.5 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3251 PF11622.8 PIK52551.1 - 0.05 13.2 0.4 0.092 12.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) APG6_N PF17675.1 PIK52551.1 - 0.063 13.8 4.8 0.091 13.3 4.8 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region CP12 PF02672.15 PIK52551.1 - 0.086 13.6 0.5 0.17 12.6 0.5 1.5 1 0 0 1 1 1 0 CP12 domain FrhB_FdhB_C PF04432.13 PIK52551.1 - 0.088 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Cep57_MT_bd PF06657.13 PIK52551.1 - 0.093 13.2 3.9 0.69 10.4 0.3 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4200 PF13863.6 PIK52551.1 - 0.096 13.1 8.2 0.36 11.3 8.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4140 PF13600.6 PIK52551.1 - 0.12 12.8 1.6 0.22 12.0 1.6 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) COMMD1_N PF17221.3 PIK52551.1 - 0.14 12.5 1.9 0.22 11.8 1.1 1.7 1 1 1 2 2 2 0 COMMD1 N-terminal domain TolA_bind_tri PF16331.5 PIK52551.1 - 0.15 12.2 2.7 0.19 11.8 1.2 1.8 2 0 0 2 2 2 0 TolA binding protein trimerisation XhlA PF10779.9 PIK52551.1 - 0.16 12.2 5.7 0.43 10.8 3.3 2.5 1 1 1 2 2 2 0 Haemolysin XhlA Matrilin_ccoil PF10393.9 PIK52551.1 - 0.2 11.5 4.6 1.8 8.5 0.8 3.1 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Spc24 PF08286.11 PIK52551.1 - 0.29 11.4 5.0 0.32 11.2 4.2 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF641 PF04859.12 PIK52551.1 - 0.31 11.4 4.5 0.32 11.3 3.6 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF4618 PF15397.6 PIK52551.1 - 0.36 10.2 9.3 0.37 10.2 2.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DUF1664 PF07889.12 PIK52551.1 - 0.41 10.7 5.7 0.59 10.2 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CorA PF01544.18 PIK52551.1 - 0.54 9.5 3.6 0.8 9.0 3.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF948 PF06103.11 PIK52551.1 - 0.54 10.6 3.9 0.44 10.8 1.8 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BRE1 PF08647.11 PIK52551.1 - 0.54 10.4 9.4 0.38 10.9 6.3 2.2 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase CCDC-167 PF15188.6 PIK52551.1 - 0.72 10.2 5.4 1.2 9.6 4.9 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 FlaC_arch PF05377.11 PIK52551.1 - 0.96 9.9 9.2 0.22 11.9 3.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Flagellin_N PF00669.20 PIK52551.1 - 1.4 9.0 6.1 0.62 10.2 1.5 2.1 1 1 0 2 2 2 0 Bacterial flagellin N-terminal helical region NPV_P10 PF05531.12 PIK52551.1 - 1.9 9.0 8.5 1.1 9.8 3.4 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_25 PF13481.6 PIK52552.1 - 0.00024 20.8 0.0 0.00055 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DED PF01335.21 PIK52552.1 - 0.00044 20.5 0.1 0.0009 19.5 0.1 1.5 1 0 0 1 1 1 1 Death effector domain Tim54 PF11711.8 PIK52553.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NACHT PF05729.12 PIK52554.1 - 2.2e-13 50.4 0.0 4.7e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain C1-set PF07654.15 PIK52554.1 - 1.3e-05 25.5 9.0 0.018 15.4 1.1 3.1 3 0 0 3 3 3 2 Immunoglobulin C1-set domain V-set PF07686.17 PIK52554.1 - 1.4e-05 25.2 1.4 0.23 11.6 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK52554.1 - 2.9e-05 24.0 5.4 0.0033 17.5 0.9 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK52554.1 - 5e-05 23.6 2.8 1.8 9.0 0.2 4.7 4 0 0 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK52554.1 - 0.00015 21.8 4.7 0.5 10.6 0.8 4.8 4 0 0 4 4 4 1 Immunoglobulin domain AAA_25 PF13481.6 PIK52554.1 - 0.00043 19.9 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Phostensin PF13914.6 PIK52554.1 - 0.064 13.9 0.1 0.14 12.8 0.1 1.5 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region YajC PF02699.15 PIK52554.1 - 0.15 12.0 0.1 0.79 9.6 0.1 2.3 1 0 0 1 1 1 0 Preprotein translocase subunit NACHT PF05729.12 PIK52556.1 - 4.2e-18 65.8 0.0 2.9e-17 63.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain DDE_3 PF13358.6 PIK52556.1 - 0.00017 21.4 0.4 0.0024 17.6 0.1 2.5 2 0 0 2 2 2 1 DDE superfamily endonuclease AAA_25 PF13481.6 PIK52556.1 - 0.0026 17.4 0.0 0.0054 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Adeno_E3_CR2 PF02439.15 PIK52556.1 - 0.012 15.4 5.0 0.027 14.2 5.0 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 C2-set_2 PF08205.12 PIK52556.1 - 0.016 15.3 0.4 0.082 13.0 0.1 2.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain AAA_22 PF13401.6 PIK52556.1 - 0.017 15.4 0.0 0.06 13.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain EphA2_TM PF14575.6 PIK52556.1 - 0.031 15.1 0.2 0.089 13.7 0.2 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_3 PF13927.6 PIK52556.1 - 0.064 13.9 0.8 22 5.7 0.1 4.4 3 1 1 4 4 4 0 Immunoglobulin domain V-set PF07686.17 PIK52556.1 - 0.094 12.9 2.6 0.78 9.9 0.0 3.1 4 0 0 4 4 3 0 Immunoglobulin V-set domain AAA_16 PF13191.6 PIK52556.1 - 0.13 12.6 0.0 0.64 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain TMEM154 PF15102.6 PIK52556.1 - 1.1 9.2 4.2 0.96 9.3 0.7 2.3 2 0 0 2 2 2 0 TMEM154 protein family ZU5 PF00791.20 PIK52558.1 - 2.8e-24 85.3 0.2 4e-13 49.5 0.0 3.2 2 0 0 2 2 2 2 ZU5 domain ERM PF00769.19 PIK52558.1 - 4.3e-09 36.6 208.3 0.00051 19.9 47.9 6.2 1 1 4 5 5 5 4 Ezrin/radixin/moesin family GAS PF13851.6 PIK52558.1 - 0.00016 21.1 198.5 0.0033 16.8 29.3 8.2 3 1 5 8 8 8 5 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK52558.1 - 0.01 16.4 31.9 0.01 16.4 31.9 8.9 2 1 5 7 7 7 0 Apg6 coiled-coil region KASH_CCD PF14662.6 PIK52558.1 - 0.14 11.9 179.8 0.13 12.0 13.0 8.7 1 1 6 7 7 7 0 Coiled-coil region of CCDC155 or KASH NACHT PF05729.12 PIK52559.1 - 2.2e-18 66.7 0.0 4e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK52559.1 - 0.00036 19.8 0.0 0.00055 19.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK52559.1 - 0.00089 18.9 0.1 0.0063 16.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK52559.1 - 0.0057 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK52559.1 - 0.038 14.3 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK52559.1 - 0.039 13.1 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF4364 PF14277.6 PIK52559.1 - 0.068 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) C2-set_2 PF08205.12 PIK52559.1 - 0.12 12.4 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF4723 PF15851.5 PIK52559.1 - 0.12 12.5 0.2 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4723) AIG1 PF04548.16 PIK52560.1 - 1.2e-29 103.2 0.0 1.7e-29 102.6 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK52560.1 - 6.2e-09 35.9 0.0 9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK52560.1 - 6e-05 23.2 2.8 0.096 12.7 0.0 2.6 2 1 1 3 3 3 2 Dynamin family RNA_helicase PF00910.22 PIK52560.1 - 0.00028 21.3 0.0 0.00056 20.3 0.0 1.5 2 0 0 2 2 2 1 RNA helicase IIGP PF05049.13 PIK52560.1 - 0.0017 17.5 0.0 0.0022 17.1 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 PIK52560.1 - 0.0034 17.3 0.1 0.0053 16.7 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase CASP_C PF08172.12 PIK52560.1 - 0.0055 16.1 0.2 0.0088 15.4 0.2 1.3 1 0 0 1 1 1 1 CASP C terminal ABC_tran PF00005.27 PIK52560.1 - 0.006 17.1 0.0 0.0085 16.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.18 PIK52560.1 - 0.01 15.3 0.0 0.017 14.7 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.18 PIK52560.1 - 0.035 13.4 0.2 0.08 12.2 0.1 1.6 1 1 0 1 1 1 0 Septin AAA_10 PF12846.7 PIK52560.1 - 0.049 12.5 0.0 0.073 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_7 PF12775.7 PIK52560.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 PIK52560.1 - 0.097 12.9 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 PIK52560.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF87 PF01935.17 PIK52560.1 - 0.25 11.4 4.0 0.33 11.0 0.7 2.4 1 1 2 3 3 3 0 Helicase HerA, central domain Retrotrans_gag PF03732.17 PIK52562.1 - 0.037 14.3 0.0 0.06 13.6 0.0 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein RVT_1 PF00078.27 PIK52563.1 - 3.4e-17 62.7 0.1 3.9e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YHYH PF14240.6 PIK52564.1 - 4.5e-25 88.7 2.1 2.7e-16 60.1 0.0 2.4 1 1 1 2 2 2 2 YHYH protein YHYH PF14240.6 PIK52565.1 - 1.3e-24 87.3 1.0 2.3e-16 60.3 0.0 2.3 1 1 1 2 2 2 2 YHYH protein Mfa1 PF17445.2 PIK52566.1 - 0.11 12.5 1.0 0.41 10.7 1.0 1.9 1 0 0 1 1 1 0 Mating factor A1 Iso_dh PF00180.20 PIK52567.1 - 5.8e-66 223.0 0.0 7.4e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SBF PF01758.16 PIK52568.1 - 6.5e-29 101.0 14.2 1.5e-28 99.9 14.2 1.6 1 0 0 1 1 1 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK52568.1 - 0.001 17.5 7.4 0.36 9.2 0.0 2.5 2 0 0 2 2 2 2 Membrane transport protein DUF2681 PF10883.8 PIK52568.1 - 0.095 13.1 0.3 0.3 11.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) SBF PF01758.16 PIK52569.1 - 4.9e-27 94.9 13.2 4.9e-27 94.9 13.2 1.8 2 0 0 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK52569.1 - 0.021 13.3 7.2 0.044 12.2 1.3 2.8 2 1 1 3 3 3 0 Membrane transport protein SBF PF01758.16 PIK52570.1 - 4e-18 65.8 6.5 5.5e-18 65.3 6.5 1.3 1 1 0 1 1 1 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK52570.1 - 0.00045 18.7 0.4 0.0057 15.1 1.7 1.9 2 0 0 2 2 2 1 Membrane transport protein ATP-synt_ab PF00006.25 PIK52571.1 - 2.1e-68 230.1 0.0 3.1e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 PIK52571.1 - 1.9e-12 47.5 0.3 4.2e-12 46.4 0.2 1.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain 7tm_1 PF00001.21 PIK52572.1 - 7.1e-21 74.7 7.5 9e-21 74.4 7.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4635 PF15466.6 PIK52572.1 - 0.15 11.5 0.2 3.2 7.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) DUF3021 PF11457.8 PIK52572.1 - 0.25 11.7 13.8 1.3 9.3 7.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) 7tm_1 PF00001.21 PIK52573.1 - 2.8e-17 62.9 0.1 4.8e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK52573.1 - 2.6e-05 23.7 0.1 3.6e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx MADF_DNA_bdg PF10545.9 PIK52574.1 - 0.00011 22.5 1.8 0.00011 22.5 1.8 2.6 3 0 0 3 3 3 1 Alcohol dehydrogenase transcription factor Myb/SANT-like DDE_Tnp_4 PF13359.6 PIK52575.1 - 4e-29 101.3 0.0 6.1e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK52575.1 - 8.4e-12 45.1 0.1 1.8e-11 44.0 0.1 1.5 1 1 0 1 1 1 1 Plant transposon protein 7tm_1 PF00001.21 PIK52576.1 - 3.9e-40 137.8 11.7 6.1e-40 137.2 11.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK52576.1 - 6.6e-10 38.8 11.3 8.9e-10 38.4 11.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK52576.1 - 1.4e-05 24.5 10.5 7.5e-05 22.2 10.5 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw MtN3_slv PF03083.16 PIK52577.1 - 1.8e-20 72.8 6.2 1.8e-20 72.8 6.2 1.9 3 0 0 3 3 3 1 Sugar efflux transporter for intercellular exchange DUF2157 PF09925.9 PIK52577.1 - 0.029 14.2 0.7 0.029 14.2 0.7 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) LAB_N PF07578.11 PIK52577.1 - 0.064 13.4 1.7 0.069 13.2 0.2 2.0 2 1 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain PQ-loop PF04193.14 PIK52577.1 - 0.22 11.3 7.1 0.31 10.8 2.6 2.8 1 1 1 2 2 2 0 PQ loop repeat WD40 PF00400.32 PIK52578.1 - 7.1e-18 64.6 17.2 0.00087 20.1 0.5 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK52578.1 - 1.1e-06 28.8 0.3 0.48 10.8 0.0 4.3 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK52578.1 - 1.5e-05 23.9 0.3 0.042 12.5 0.0 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 JMY PF15871.5 PIK52579.1 - 5e-93 312.2 20.1 5e-93 312.2 20.1 2.2 2 0 0 2 2 2 1 Junction-mediating and -regulatory protein WHAMM-JMY_N PF15920.5 PIK52579.1 - 2.8e-13 49.5 0.1 9.3e-13 47.8 0.1 1.8 1 0 0 1 1 1 1 N-terminal of Junction-mediating and WASP homolog-associated CAP_N PF01213.19 PIK52579.1 - 0.19 11.2 12.2 0.62 9.5 12.2 1.9 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 PIK52579.1 - 0.24 11.4 14.1 0.053 13.6 8.8 2.7 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 PIK52579.1 - 0.82 9.7 15.6 1.7 8.7 15.6 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Na_Pi_cotrans PF02690.15 PIK52580.1 - 4e-41 140.4 18.3 9.5e-25 87.3 6.1 2.3 2 0 0 2 2 2 2 Na+/Pi-cotransporter DUF2207 PF09972.9 PIK52580.1 - 0.017 13.9 1.7 0.8 8.4 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Shisa PF13908.6 PIK52581.1 - 0.0012 19.1 0.2 0.0012 19.1 0.2 2.3 2 1 1 3 3 3 1 Wnt and FGF inhibitory regulator TMEM51 PF15345.6 PIK52581.1 - 0.011 15.6 0.2 0.027 14.3 0.0 1.7 2 1 1 3 3 3 0 Transmembrane protein 51 DUF3517 PF12030.8 PIK52581.1 - 0.024 13.5 0.1 0.032 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) rve PF00665.26 PIK52582.1 - 4.2e-24 85.0 0.0 6.8e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52582.1 - 1.4e-16 60.3 2.7 2.8e-16 59.4 2.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK52582.1 - 9.9e-09 34.9 0.1 2.8e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK52582.1 - 0.0023 18.0 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Abhydrolase_1 PF00561.20 PIK52584.1 - 2e-14 53.9 1.2 2.4e-10 40.5 0.0 3.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK52584.1 - 2e-09 38.4 0.1 9.4e-09 36.2 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 PIK52584.1 - 2.6e-07 29.6 0.0 3e-05 22.9 0.0 2.7 1 1 1 2 2 2 2 Ndr family Hydrolase_4 PF12146.8 PIK52584.1 - 0.0022 17.3 0.0 0.0068 15.7 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 PIK52584.1 - 0.014 15.1 0.0 0.049 13.3 0.0 1.7 1 1 1 2 2 2 0 PGAP1-like protein SLC3A2_N PF16028.5 PIK52584.1 - 0.21 11.2 0.8 0.39 10.3 0.8 1.5 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Myb_DNA-binding PF00249.31 PIK52585.1 - 1.2e-10 41.4 0.2 1.2e-10 41.4 0.2 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM PF04433.17 PIK52585.1 - 1.7e-07 31.5 0.2 1.1e-06 28.9 0.1 2.4 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 PIK52585.1 - 2.1e-07 31.1 0.0 7.2e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain RPA_C PF08784.11 PIK52585.1 - 0.021 15.5 0.1 0.069 13.8 0.0 1.9 2 0 0 2 2 2 0 Replication protein A C terminal Not3 PF04065.15 PIK52585.1 - 0.045 13.2 1.3 0.078 12.4 1.3 1.4 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component ZZ PF00569.17 PIK52585.1 - 0.088 12.6 2.2 0.19 11.6 2.2 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type U1snRNP70_N PF12220.8 PIK52587.1 - 0.12 13.1 0.6 0.27 11.9 0.3 1.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal FAM60A PF15396.6 PIK52589.1 - 5.3 7.0 8.9 5.1 7.0 1.6 2.1 2 0 0 2 2 2 0 Protein Family FAM60A SPRY PF00622.28 PIK52591.1 - 6.3e-17 61.8 0.1 8e-08 32.4 0.0 2.6 2 0 0 2 2 2 2 SPRY domain PHD PF00628.29 PIK52591.1 - 0.0017 18.2 13.8 0.0031 17.4 13.8 1.4 1 0 0 1 1 1 1 PHD-finger Neuralized PF07177.12 PIK52591.1 - 0.02 14.9 0.0 0.061 13.3 0.0 1.8 1 0 0 1 1 1 0 Neuralized Zf_RING PF16744.5 PIK52591.1 - 0.31 11.2 4.1 1.6 8.9 3.6 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger NTS_2 PF15448.6 PIK52591.1 - 3 8.3 5.0 1 9.8 0.1 2.7 3 0 0 3 3 3 0 N-terminal segments of P. falciparum erythrocyte membrane protein 60KD_IMP PF02096.20 PIK52592.1 - 2e-15 57.1 0.1 2e-14 53.8 0.1 2.1 1 1 0 1 1 1 1 60Kd inner membrane protein DnaJ_CXXCXGXG PF00684.19 PIK52593.1 - 0.28 11.6 1.2 0.6 10.5 1.2 1.5 1 0 0 1 1 1 0 DnaJ central domain PXA PF02194.15 PIK52594.1 - 5.4e-30 104.7 0.4 9.9e-30 103.9 0.4 1.4 1 0 0 1 1 1 1 PXA domain RGS PF00615.19 PIK52594.1 - 1e-11 45.1 2.2 1.7e-11 44.5 2.2 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ncstrn_small PF18266.1 PIK52594.1 - 0.092 12.8 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Nicastrin small lobe Pre-PUA PF17832.1 PIK52594.1 - 0.11 13.1 0.0 0.43 11.3 0.0 2.0 2 0 0 2 2 2 0 Pre-PUA-like domain PMM PF03332.13 PIK52595.1 - 2.5e-99 331.5 1.5 2.7e-99 331.4 1.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 PIK52595.1 - 0.00058 19.7 0.2 0.013 15.2 0.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CD20 PF04103.15 PIK52596.1 - 1.8e-12 47.6 7.5 2.3e-12 47.3 7.5 1.2 1 0 0 1 1 1 1 CD20-like family Tetraspanin PF00335.20 PIK52596.1 - 0.0026 17.5 13.3 0.026 14.3 13.3 1.9 1 1 0 1 1 1 1 Tetraspanin family DHHC PF01529.20 PIK52596.1 - 0.0063 16.6 3.6 0.0071 16.5 0.4 2.0 1 1 2 3 3 3 1 DHHC palmitoyltransferase DUF3112 PF11309.8 PIK52596.1 - 0.034 13.6 2.9 0.11 11.9 1.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3112) Ninjurin PF04923.12 PIK52596.1 - 0.063 13.2 1.9 0.08 12.9 0.1 2.0 2 0 0 2 2 2 0 Ninjurin L6_membrane PF05805.12 PIK52596.1 - 0.11 12.1 14.0 0.3 10.7 0.1 2.7 2 1 1 3 3 3 0 L6 membrane protein TMEM52 PF14979.6 PIK52596.1 - 0.15 12.0 4.9 1 9.3 0.0 2.9 3 0 0 3 3 3 0 Transmembrane 52 DUF4173 PF13777.6 PIK52596.1 - 0.51 9.7 5.4 0.26 10.7 2.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4173) Neurensin PF14927.6 PIK52596.1 - 0.55 9.9 8.8 0.87 9.3 0.3 2.5 1 1 1 2 2 2 0 Neurensin Cytochrom_B558a PF05038.13 PIK52596.1 - 2.7 7.5 5.6 0.71 9.4 0.8 2.4 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit DUF3899 PF13038.6 PIK52596.1 - 2.8 8.5 5.6 18 5.9 0.8 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF3899) Sigma_reg_N PF13800.6 PIK52596.1 - 2.8 8.3 7.0 4.7 7.6 0.5 2.9 2 1 1 3 3 3 0 Sigma factor regulator N-terminal CSD PF00313.22 PIK52597.1 - 7.3e-07 28.9 0.1 9.9e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 PIK52597.1 - 0.091 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain Ribosomal_S25 PF03297.15 PIK52597.1 - 0.22 11.8 0.0 0.29 11.4 0.0 1.2 1 0 0 1 1 1 0 S25 ribosomal protein ubiquitin PF00240.23 PIK52598.1 - 4.4e-14 52.0 0.2 1.1e-13 50.7 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 PIK52598.1 - 0.0045 17.4 0.1 0.01 16.3 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain Macoilin PF09726.9 PIK52598.1 - 0.0047 15.6 4.1 0.0057 15.3 4.1 1.0 1 0 0 1 1 1 1 Macoilin family fn3 PF00041.21 PIK52599.1 - 1.1e-144 471.1 42.7 4.4e-15 55.8 0.1 14.7 14 0 0 14 14 14 13 Fibronectin type III domain Ig_3 PF13927.6 PIK52599.1 - 3.3e-65 216.7 8.5 2.6e-15 56.8 0.0 8.8 8 0 0 8 8 7 6 Immunoglobulin domain I-set PF07679.16 PIK52599.1 - 3.9e-62 206.3 0.0 3.7e-15 55.7 0.0 7.8 8 0 0 8 8 8 6 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52599.1 - 8.9e-41 138.1 0.6 3.9e-08 33.5 0.0 7.5 7 0 0 7 7 7 5 Immunoglobulin domain ig PF00047.25 PIK52599.1 - 1.7e-33 114.6 0.0 1.2e-06 28.6 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain V-set PF07686.17 PIK52599.1 - 1.3e-20 73.6 1.9 0.033 14.4 0.0 9.0 6 3 1 7 7 7 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 PIK52599.1 - 4.5e-15 56.0 33.1 0.57 10.8 0.1 13.8 14 0 0 14 14 14 4 Purple acid Phosphatase, N-terminal domain Ig_6 PF18452.1 PIK52599.1 - 1.8e-10 40.2 0.0 0.33 10.5 0.0 6.4 6 0 0 6 6 6 3 Immunoglobulin domain fn3_2 PF16893.5 PIK52599.1 - 1.5e-08 34.6 5.2 0.12 12.6 0.0 6.7 8 0 0 8 8 7 2 Fibronectin type III domain Ig_4 PF16680.5 PIK52599.1 - 1.8e-08 34.5 0.0 2.8 8.3 0.0 6.0 6 0 0 6 6 6 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK52599.1 - 3.3e-08 33.5 1.2 0.06 13.4 0.0 4.7 5 0 0 5 5 4 3 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.10 PIK52599.1 - 4.1e-08 33.5 0.1 3.3 8.1 0.0 7.4 8 0 0 8 8 8 1 Interferon-alpha/beta receptor, fibronectin type III Receptor_2B4 PF11465.8 PIK52599.1 - 1.8e-06 28.1 0.8 0.18 12.0 0.0 4.9 6 0 0 6 6 5 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 PIK52599.1 - 0.00066 19.7 0.0 24 5.1 0.0 4.4 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain DUF2369 PF10179.9 PIK52599.1 - 0.0049 17.2 0.0 1e+02 3.4 0.0 5.5 5 1 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) BiPBP_C PF06832.12 PIK52599.1 - 0.054 13.5 0.0 3.9 7.6 0.0 3.3 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family SUI1 PF01253.22 PIK52600.1 - 6.8e-25 87.4 1.1 8.5e-25 87.1 1.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 SH3_19 PF18597.1 PIK52600.1 - 0.036 13.9 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain TNFR_c6 PF00020.18 PIK52601.1 - 3.4e-14 52.9 15.5 3e-07 30.7 8.2 2.4 2 0 0 2 2 2 2 TNFR/NGFR cysteine-rich region TNFR_16_TM PF18422.1 PIK52601.1 - 2.6e-10 40.1 3.2 5e-10 39.2 3.2 1.4 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain Death PF00531.22 PIK52601.1 - 0.00016 21.8 0.3 0.00028 21.0 0.3 1.3 1 0 0 1 1 1 1 Death domain LapA_dom PF06305.11 PIK52601.1 - 0.0061 16.4 0.1 0.0097 15.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Ldl_recept_a PF00057.18 PIK52602.1 - 4.5e-10 39.6 36.0 3.5e-05 23.9 5.0 3.5 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A DUF2828 PF11443.8 PIK52602.1 - 0.26 9.3 9.5 0.46 8.5 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) USP8_interact PF08941.10 PIK52603.1 - 1.9e-79 265.6 1.5 2.7e-79 265.1 1.5 1.2 1 0 0 1 1 1 1 USP8 interacting zf-C3HC4_2 PF13923.6 PIK52603.1 - 1.1e-11 44.3 7.2 1.1e-11 44.3 7.2 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK52603.1 - 1.5e-09 38.0 6.4 6.3e-09 36.0 6.4 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK52603.1 - 8.8e-09 35.1 5.7 8.8e-09 35.1 5.7 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK52603.1 - 1.9e-07 30.8 3.5 1.9e-07 30.8 3.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK52603.1 - 2e-07 31.2 4.2 2e-07 31.2 4.2 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK52603.1 - 3e-07 30.3 7.6 8.8e-07 28.9 7.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK52603.1 - 1e-06 28.7 6.5 1e-06 28.7 6.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 PIK52603.1 - 3e-06 27.0 0.7 8.6e-06 25.5 0.7 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.15 PIK52603.1 - 3.4e-06 27.1 0.0 1.5e-05 25.1 0.0 2.2 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.6 PIK52603.1 - 8.2e-06 25.7 3.8 8.2e-06 25.7 3.8 2.1 2 0 0 2 2 1 1 zinc-RING finger domain zf-Nse PF11789.8 PIK52603.1 - 2.2e-05 24.1 2.0 6.7e-05 22.6 1.3 2.2 2 0 0 2 2 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 PIK52603.1 - 0.0012 18.8 1.4 0.0012 18.8 1.4 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 PIK52603.1 - 0.0015 18.3 6.5 0.11 12.4 7.3 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 PIK52603.1 - 0.0017 18.5 5.4 0.0033 17.5 3.7 2.3 2 0 0 2 2 2 1 zinc RING finger of MSL2 Sina PF03145.16 PIK52603.1 - 0.0031 17.5 1.8 0.0067 16.4 1.8 1.6 1 0 0 1 1 1 1 Seven in absentia protein family Trimer_CC PF08954.11 PIK52603.1 - 0.027 14.0 0.1 0.068 12.7 0.1 1.7 1 0 0 1 1 1 0 Trimerisation motif FlaC_arch PF05377.11 PIK52603.1 - 0.061 13.7 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4677 PF15726.5 PIK52603.1 - 0.082 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) SlyX PF04102.12 PIK52603.1 - 0.15 12.7 0.5 0.44 11.2 0.2 1.9 1 1 0 1 1 1 0 SlyX TolA_bind_tri PF16331.5 PIK52603.1 - 0.15 12.1 2.8 0.6 10.2 2.8 2.0 1 1 0 1 1 1 0 TolA binding protein trimerisation Pox_A_type_inc PF04508.12 PIK52603.1 - 0.81 9.6 4.1 4.9 7.2 0.0 2.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Zn_ribbon_17 PF17120.5 PIK52603.1 - 1 9.0 12.8 0.075 12.7 3.9 2.9 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-TRAF_2 PF15965.5 PIK52603.1 - 2.1 8.9 12.4 0.43 11.1 5.5 3.0 2 1 1 3 3 3 0 TRAF-like zinc-finger zf-TRAF PF02176.18 PIK52603.1 - 3.8 8.3 14.2 2.9 8.7 4.2 3.6 2 1 1 3 3 2 0 TRAF-type zinc finger zf_C2HC_14 PF18574.1 PIK52603.1 - 8.5 6.3 8.2 0.27 11.1 0.6 2.2 2 0 0 2 2 2 0 C2HC Zing finger domain IBR PF01485.21 PIK52603.1 - 9.3 6.6 13.3 0.22 11.8 3.3 2.9 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Orn_Arg_deC_N PF02784.16 PIK52604.1 - 5.6e-60 202.8 0.0 6.8e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Exo_endo_phos PF03372.23 PIK52605.1 - 4.4e-11 42.7 0.0 1.2e-10 41.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 PIK52606.1 - 5.9e-52 176.6 0.0 8.5e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52606.1 - 2.8e-28 98.9 0.0 3.8e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 PIK52606.1 - 4e-12 46.0 0.0 3.5e-11 43.0 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain fn3 PF00041.21 PIK52606.1 - 1.3e-11 44.6 0.1 2.3e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Ig_3 PF13927.6 PIK52606.1 - 3.5e-09 37.1 0.0 1.5e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK52606.1 - 1.3e-07 31.8 0.1 5.1e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK52606.1 - 1.8e-05 24.8 0.1 5.4e-05 23.3 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin domain Kinase-like PF14531.6 PIK52606.1 - 0.0037 16.6 0.1 0.017 14.5 0.1 2.0 1 1 0 1 1 1 1 Kinase-like Pur_ac_phosph_N PF16656.5 PIK52606.1 - 0.0066 17.0 0.2 0.037 14.6 0.2 2.3 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 PIK52606.1 - 0.018 15.1 0.6 0.095 12.8 0.6 2.2 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Vfa1 PF08432.10 PIK52608.1 - 7 6.9 15.1 0.38 11.1 8.1 1.9 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pkinase PF00069.25 PIK52609.1 - 1.7e-67 227.6 0.2 2e-67 227.4 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52609.1 - 1.9e-36 125.7 0.0 2.6e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK52609.1 - 0.0039 16.6 0.0 0.0061 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family fn3 PF00041.21 PIK52609.1 - 0.02 15.2 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain Tubulin_3 PF14881.6 PIK52609.1 - 0.031 13.9 0.3 0.068 12.9 0.3 1.5 1 0 0 1 1 1 0 Tubulin domain APH PF01636.23 PIK52609.1 - 0.19 11.6 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family EamA PF00892.20 PIK52610.1 - 3.7e-11 43.4 26.1 6.7e-06 26.3 15.4 2.3 2 0 0 2 2 2 2 EamA-like transporter family BsuPI PF12690.7 PIK52611.1 - 0.1 12.7 0.6 1.4 8.9 0.0 2.8 4 0 0 4 4 4 0 Intracellular proteinase inhibitor Y_phosphatase PF00102.27 PIK52612.1 - 2.3e-106 354.6 7.8 4.6e-42 144.2 1.8 3.4 2 1 1 3 3 3 3 Protein-tyrosine phosphatase fn3 PF00041.21 PIK52612.1 - 1.1e-08 35.3 0.2 5.9e-08 33.0 0.1 2.3 2 0 0 2 2 2 1 Fibronectin type III domain DSPc PF00782.20 PIK52612.1 - 2.8e-08 33.7 0.4 0.0029 17.4 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK52612.1 - 3.4e-06 27.2 0.0 0.034 14.1 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK52612.1 - 3.2e-05 24.1 0.2 0.018 15.2 0.0 3.3 3 0 0 3 3 3 1 Inositol hexakisphosphate EGF_2 PF07974.13 PIK52612.1 - 0.00021 21.6 11.6 0.00021 21.6 11.6 4.3 3 1 1 4 4 4 1 EGF-like domain Pur_ac_phosph_N PF16656.5 PIK52612.1 - 0.0013 19.3 0.1 0.0062 17.1 0.0 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain hEGF PF12661.7 PIK52612.1 - 0.013 16.1 5.6 0.013 16.1 5.6 4.7 4 0 0 4 4 4 0 Human growth factor-like EGF Tk-SP_N-pro PF18237.1 PIK52612.1 - 0.018 15.1 0.1 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 Tk-SP N-propeptide domain RVT_1 PF00078.27 PIK52613.1 - 5.4e-23 81.7 0.0 6.7e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4371 PF14291.6 PIK52614.1 - 1.3e-08 34.8 0.0 2.5e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 PIK52614.1 - 1.2e-05 25.0 0.1 3e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.15 PIK52614.1 - 0.0027 17.6 0.0 0.0072 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) fn3 PF00041.21 PIK52615.1 - 3.9e-05 23.9 0.5 9.8e-05 22.6 0.5 1.7 1 1 0 1 1 1 1 Fibronectin type III domain Y_phosphatase PF00102.27 PIK52616.1 - 8.3e-110 365.9 1.6 1.6e-56 191.5 0.1 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK52616.1 - 2.6e-10 40.2 0.7 0.00043 20.1 0.2 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK52616.1 - 1.7e-05 25.0 0.0 0.0062 16.7 0.0 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK52616.1 - 2.4e-05 24.4 0.0 0.057 13.4 0.0 2.6 3 0 0 3 3 3 2 Tyrosine phosphatase family Myotub-related PF06602.14 PIK52616.1 - 0.002 17.1 0.4 0.27 10.1 0.3 2.5 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Y_phosphatase2 PF03162.13 PIK52616.1 - 0.0039 16.8 0.9 0.88 9.1 0.0 2.8 2 1 0 2 2 2 2 Tyrosine phosphatase family NACHT PF05729.12 PIK52618.1 - 1.3e-14 54.5 0.0 3e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK52618.1 - 7.2e-10 39.0 1.8 0.00017 21.7 0.2 3.1 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52618.1 - 8e-09 36.0 3.7 0.0062 17.1 0.1 4.6 3 1 1 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK52618.1 - 9.9e-07 28.7 3.9 0.02 14.9 0.4 3.6 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52618.1 - 1.6e-06 28.3 3.2 0.15 12.4 0.1 4.2 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK52618.1 - 6.4e-06 26.2 3.8 0.26 11.5 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain Chordopox_A13L PF05961.11 PIK52618.1 - 0.00084 19.5 0.4 0.014 15.6 0.5 2.6 2 0 0 2 2 2 1 Chordopoxvirus A13L protein AAA_22 PF13401.6 PIK52618.1 - 0.0044 17.3 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Izumo-Ig PF16706.5 PIK52618.1 - 0.0062 16.6 0.1 0.041 13.9 0.1 2.4 1 1 0 1 1 1 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 PIK52618.1 - 0.017 15.2 0.4 0.23 11.5 0.2 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ECSCR PF15820.5 PIK52618.1 - 0.026 14.3 0.6 0.071 12.9 0.6 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator AAA_25 PF13481.6 PIK52618.1 - 0.05 13.2 0.0 0.23 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain TMEM154 PF15102.6 PIK52618.1 - 0.056 13.4 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF5305 PF17231.2 PIK52618.1 - 0.08 12.3 0.6 0.23 10.8 0.6 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Pilin_N PF07790.11 PIK52618.1 - 0.11 13.4 2.1 0.42 11.6 2.1 2.0 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF4834 PF16118.5 PIK52618.1 - 0.15 13.1 0.4 0.34 11.9 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Insulin_TMD PF17870.1 PIK52618.1 - 0.2 11.8 4.6 0.55 10.3 4.6 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment NACHT PF05729.12 PIK52619.1 - 6.4e-15 55.5 0.0 1.1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK52619.1 - 0.0046 17.5 0.5 0.15 12.6 0.1 3.1 2 1 1 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK52619.1 - 0.013 15.7 0.0 0.033 14.4 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain AAA_22 PF13401.6 PIK52619.1 - 0.014 15.7 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK52619.1 - 0.018 14.6 0.0 0.048 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ig PF00047.25 PIK52619.1 - 0.04 14.1 0.1 0.32 11.2 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin domain AAA_14 PF13173.6 PIK52619.1 - 0.068 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain I-set PF07679.16 PIK52619.1 - 0.11 12.6 0.2 4.3 7.5 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin I-set domain NACHT PF05729.12 PIK52620.1 - 2.1e-08 34.2 0.0 5.7e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK52620.1 - 0.017 14.7 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3627 PF12299.8 PIK52620.1 - 0.21 11.7 1.9 14 5.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3627) Pkinase_Tyr PF07714.17 PIK52621.1 - 4.1e-32 111.5 0.1 5.6e-32 111.0 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52621.1 - 3.3e-24 85.7 0.1 4.8e-24 85.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK52621.1 - 2.9e-06 27.3 0.0 8e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK52621.1 - 0.0078 16.6 0.0 0.03 14.7 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain PNMA PF14893.6 PIK52622.1 - 0.00048 19.6 0.2 0.00053 19.5 0.2 1.1 1 0 0 1 1 1 1 PNMA Spuma_A9PTase PF03539.14 PIK52623.1 - 0.024 14.8 0.0 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Herpes_ORF11 PF04797.13 PIK52623.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus dUTPase protein rve PF00665.26 PIK52624.1 - 5e-22 78.3 0.0 8.5e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52624.1 - 8e-20 70.7 0.8 1.4e-19 69.9 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK52624.1 - 0.0045 16.7 0.0 0.013 15.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK52624.1 - 0.0098 16.1 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DUF5332 PF17266.2 PIK52624.1 - 0.012 15.3 0.0 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5332) V-set PF07686.17 PIK52626.1 - 3e-08 33.8 0.3 0.016 15.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52626.1 - 1.3e-07 32.1 5.6 0.099 13.3 0.0 5.0 4 1 1 5 5 5 2 Immunoglobulin domain ig PF00047.25 PIK52626.1 - 1.9e-05 24.7 1.9 0.059 13.6 0.0 4.2 4 0 0 4 4 4 1 Immunoglobulin domain TMEM154 PF15102.6 PIK52626.1 - 3.9e-05 23.6 0.3 9.5e-05 22.3 0.3 1.7 1 0 0 1 1 1 1 TMEM154 protein family Ig_2 PF13895.6 PIK52626.1 - 0.00011 22.5 1.0 0.53 10.7 0.0 4.3 3 1 1 4 4 4 1 Immunoglobulin domain NACHT PF05729.12 PIK52626.1 - 0.0014 18.6 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DUF2207 PF09972.9 PIK52626.1 - 0.0072 15.1 0.1 0.04 12.7 0.0 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) DUF3377 PF11857.8 PIK52626.1 - 0.011 15.7 0.5 0.03 14.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) SKG6 PF08693.10 PIK52626.1 - 0.016 14.6 3.9 0.037 13.4 3.9 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Shisa PF13908.6 PIK52626.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator I-set PF07679.16 PIK52626.1 - 0.02 15.0 1.8 12 6.0 0.0 3.8 4 0 0 4 4 4 0 Immunoglobulin I-set domain CD34_antigen PF06365.12 PIK52626.1 - 0.026 14.1 0.3 0.044 13.4 0.3 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4448 PF14610.6 PIK52626.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) GntP_permease PF02447.16 PIK52626.1 - 0.074 11.7 0.2 0.11 11.2 0.2 1.1 1 0 0 1 1 1 0 GntP family permease Orf78 PF06024.12 PIK52626.1 - 0.082 13.2 0.3 0.18 12.1 0.3 1.5 1 0 0 1 1 1 0 Orf78 (ac78) LRR19-TM PF15176.6 PIK52626.1 - 0.092 12.7 0.0 0.46 10.5 0.0 2.2 2 0 0 2 2 1 0 Leucine-rich repeat family 19 TM domain DAG1 PF05454.11 PIK52626.1 - 0.14 11.5 4.6 0.11 11.9 2.1 2.1 2 1 1 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) C1-set PF07654.15 PIK52626.1 - 0.21 12.0 1.8 7.3 7.1 0.1 3.6 3 2 2 5 5 5 0 Immunoglobulin C1-set domain DUF4519 PF15012.6 PIK52626.1 - 0.21 11.8 0.6 0.56 10.4 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) DUF5383 PF17355.2 PIK52626.1 - 0.89 9.9 3.5 0.44 10.9 0.8 1.8 2 0 0 2 2 1 0 Family of unknown function (DUF5383) zf-H2C2_2 PF13465.6 PIK52628.1 - 3.9e-65 213.6 111.0 1.3e-07 31.7 3.4 14.0 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52628.1 - 8.4e-40 133.1 113.6 5.9e-05 23.3 1.2 13.8 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52628.1 - 1.4e-34 115.7 105.2 0.0032 18.2 1.0 13.8 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK52628.1 - 8.6e-14 51.4 85.8 0.048 14.0 0.1 13.6 13 0 0 13 13 13 8 Zinc-finger double-stranded RNA-binding Sprouty PF05210.13 PIK52628.1 - 0.00028 21.2 42.8 0.014 15.8 3.6 4.5 4 0 0 4 4 4 4 Sprouty protein (Spry) zf-H2C2_5 PF13909.6 PIK52628.1 - 0.00032 20.4 12.7 0.00089 19.0 3.2 9.9 10 0 0 10 10 10 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 PIK52628.1 - 0.0056 16.7 1.5 0.0056 16.7 1.5 13.6 14 0 0 14 14 14 7 C2H2-type zinc finger DUF3268 PF11672.8 PIK52628.1 - 0.084 13.2 0.3 0.084 13.2 0.3 6.5 3 3 2 6 6 6 0 zinc-finger-containing domain GAGA PF09237.11 PIK52628.1 - 0.18 11.6 16.4 9 6.2 0.1 5.5 4 2 2 6 6 6 0 GAGA factor zf-met PF12874.7 PIK52628.1 - 0.88 10.1 92.1 0.039 14.3 1.8 12.2 13 0 0 13 13 12 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK52628.1 - 7.4 7.4 49.7 0.92 10.3 5.2 6.9 2 2 5 7 7 7 0 zinc-ribbon family Zn_ribbon_SprT PF17283.2 PIK52628.1 - 8.1 6.5 45.4 0.11 12.5 3.9 6.5 4 2 2 6 6 6 0 SprT-like zinc ribbon domain Pkinase_Tyr PF07714.17 PIK52629.1 - 6.3e-30 104.3 0.0 8.4e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52629.1 - 1e-17 64.4 0.1 1.7e-17 63.7 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Phycoerythr_ab PF02972.14 PIK52629.1 - 0.14 12.0 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain V-set PF07686.17 PIK52630.1 - 1.1e-12 48.1 0.3 8.5e-05 22.7 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK52630.1 - 2.4e-09 37.7 7.5 0.069 13.7 0.0 5.8 5 1 1 6 6 6 3 Immunoglobulin domain ig PF00047.25 PIK52630.1 - 5.2e-08 32.9 10.7 0.003 17.7 0.0 6.2 5 2 1 6 6 6 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK52630.1 - 1.6e-07 31.3 5.7 0.034 14.2 0.1 3.9 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK52630.1 - 7.2e-06 26.0 0.3 0.49 10.5 0.0 4.3 4 0 0 4 4 4 2 Immunoglobulin I-set domain NACHT PF05729.12 PIK52630.1 - 0.00029 20.8 0.0 0.00059 19.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF5484 PF17583.2 PIK52630.1 - 0.0018 17.9 0.0 2.2 8.0 0.0 2.8 2 0 0 2 2 2 2 Family of unknown function (DUF5484) EphA2_TM PF14575.6 PIK52630.1 - 0.043 14.7 0.0 0.16 12.8 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AAA_25 PF13481.6 PIK52630.1 - 0.1 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DED PF01335.21 PIK52631.1 - 0.021 15.1 0.1 0.04 14.2 0.1 1.5 1 0 0 1 1 1 0 Death effector domain FHA PF00498.26 PIK52631.1 - 0.025 14.9 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 FHA domain DUF2095 PF09868.9 PIK52631.1 - 0.035 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) UvdE PF03851.14 PIK52631.1 - 0.068 12.4 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 UV-endonuclease UvdE HAGH_C PF16123.5 PIK52632.1 - 0.1 13.1 0.1 0.54 10.8 0.0 2.1 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus AA_permease_2 PF13520.6 PIK52633.1 - 1.1e-07 31.0 6.6 1.3e-07 30.8 6.6 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 PIK52633.1 - 0.0032 16.6 4.3 0.0038 16.3 4.3 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Spore_permease PF03845.13 PIK52633.1 - 0.023 13.5 1.6 0.027 13.3 1.6 1.1 1 0 0 1 1 1 0 Spore germination protein SpoVAB PF13782.6 PIK52633.1 - 0.038 14.3 1.1 0.046 14.0 1.1 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AB AA_permease_2 PF13520.6 PIK52634.1 - 4.8e-27 94.9 17.6 5.7e-27 94.6 17.6 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK52634.1 - 3.4e-09 35.8 16.9 5e-09 35.3 16.9 1.2 1 0 0 1 1 1 1 Amino acid permease DUF389 PF04087.14 PIK52634.1 - 0.0033 17.5 3.1 0.0071 16.4 1.5 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF389) p450 PF00067.22 PIK52635.1 - 6.5e-90 302.1 0.0 8e-90 301.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GLTP PF08718.11 PIK52635.1 - 0.14 12.5 0.0 0.86 9.9 0.0 2.1 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) Palm_thioest PF02089.15 PIK52636.1 - 3e-58 197.5 0.3 3.9e-56 190.6 0.3 2.0 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 PIK52636.1 - 0.014 15.0 0.1 0.027 14.1 0.1 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold eIF3_N PF09440.10 PIK52637.1 - 9.7e-25 87.5 1.4 9.7e-25 87.5 1.4 2.5 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 PIK52637.1 - 9e-15 55.1 0.0 9e-15 55.1 0.0 2.4 2 1 0 2 2 2 1 PCI domain TPR_3 PF07720.12 PIK52637.1 - 0.0046 16.9 2.0 0.013 15.5 2.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 PIK52637.1 - 0.048 13.7 0.6 0.27 11.2 0.1 2.3 1 1 1 2 2 2 0 CSN8/PSMD8/EIF3K family ApoLp-III PF07464.11 PIK52637.1 - 0.88 9.7 5.5 0.35 11.0 0.3 2.7 4 0 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) rve PF00665.26 PIK52638.1 - 1.3e-23 83.5 0.0 2.5e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52638.1 - 1.1e-10 41.5 0.9 3.1e-10 40.0 0.9 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK52638.1 - 0.006 16.8 0.9 0.015 15.5 0.9 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK52638.1 - 0.0073 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK52638.1 - 0.029 14.8 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RVT_1 PF00078.27 PIK52639.1 - 3.2e-31 108.6 0.0 4.8e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK52639.1 - 1.7e-20 72.9 0.4 5.8e-14 51.9 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52639.1 - 2.4e-18 66.3 0.3 1.6e-14 54.1 0.1 2.8 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Asp_protease PF09668.10 PIK52640.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease PNMA PF14893.6 PIK52641.1 - 0.013 14.9 0.8 0.028 13.8 0.2 1.6 1 1 1 2 2 2 0 PNMA DUF2120 PF09893.9 PIK52641.1 - 0.12 12.5 0.3 0.3 11.2 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) 7tm_1 PF00001.21 PIK52642.1 - 3.3e-24 85.7 2.0 3.7e-24 85.5 2.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK52642.1 - 1.3e-05 25.0 9.2 3e-05 23.8 9.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK52642.1 - 0.00019 20.9 4.7 0.00032 20.2 4.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF5588 PF17826.1 PIK52643.1 - 9.2e-10 37.9 8.5 4.1e-09 35.8 3.5 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5588) TPR_12 PF13424.6 PIK52643.1 - 2.9e-05 24.3 7.9 0.0026 18.0 2.8 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK52643.1 - 0.0059 16.6 2.4 5.6 7.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK52643.1 - 0.0064 16.6 1.1 4.6 7.7 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK52643.1 - 0.37 11.5 1.1 9.5 7.0 0.4 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK52643.1 - 0.59 10.4 3.5 1.1 9.5 0.4 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TUDOR PF00567.24 PIK52644.1 - 3.2e-157 514.7 5.8 1.1e-27 96.5 0.2 6.4 6 0 0 6 6 6 6 Tudor domain SMN PF06003.12 PIK52644.1 - 1.3e-13 50.9 17.8 0.0034 16.7 0.1 6.5 7 0 0 7 7 7 6 Survival motor neuron protein (SMN) DUF4537 PF15057.6 PIK52644.1 - 6.7e-10 39.0 0.5 3.5 7.7 0.0 6.3 6 0 0 6 6 6 3 Domain of unknown function (DUF4537) Agenet PF05641.12 PIK52644.1 - 9.7e-09 35.6 7.4 5.6 7.5 0.0 6.6 6 0 0 6 6 6 4 Agenet domain Spore_coat_CotO PF14153.6 PIK52644.1 - 0.0039 17.1 0.2 31 4.4 0.0 4.9 5 0 0 5 5 5 0 Spore coat protein CotO TUDOR_5 PF18359.1 PIK52644.1 - 0.069 12.9 0.7 3.8 7.3 0.1 3.0 3 0 0 3 3 3 0 Histone methyltransferase Tudor domain 1 NGP1NT PF08153.12 PIK52646.1 - 1.4e-30 106.1 0.1 2.2e-30 105.5 0.1 1.2 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 PIK52647.1 - 6.9e-10 39.0 0.1 1.5e-06 28.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK52647.1 - 0.00037 20.6 0.1 0.2 11.7 0.0 2.6 3 0 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK52647.1 - 0.00043 20.2 0.0 0.00098 19.1 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 PIK52647.1 - 0.0022 17.5 0.2 0.0057 16.2 0.1 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_18 PF13238.6 PIK52647.1 - 0.018 15.6 0.0 0.041 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 PIK52647.1 - 0.13 12.5 0.0 4 7.7 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF547 PF04784.14 PIK52649.1 - 4.3e-40 136.6 0.0 7.2e-40 135.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Glutaredoxin PF00462.24 PIK52649.1 - 2e-16 59.9 0.0 5e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin DEP PF00610.21 PIK52649.1 - 4.6e-06 26.6 0.0 9.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GST_N_3 PF13417.6 PIK52649.1 - 7.1e-05 23.1 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 PIK52649.1 - 0.062 13.7 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.6 PIK52649.1 - 0.11 12.6 0.6 0.67 10.1 0.1 2.4 2 1 1 3 3 3 0 Thioredoxin GST_N_2 PF13409.6 PIK52649.1 - 0.15 12.4 0.0 0.42 11.0 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain FKBP_C PF00254.28 PIK52650.1 - 9.9e-19 67.5 0.2 1.2e-18 67.2 0.2 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Fibrinogen_C PF00147.18 PIK52651.1 - 5.6e-76 255.2 6.9 2.6e-49 168.0 4.2 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52651.1 - 6.3e-06 26.3 19.2 6.3e-06 26.3 19.2 3.4 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52651.1 - 0.00042 20.5 8.6 0.00042 20.5 8.6 3.3 3 1 0 3 3 3 1 EGF domain EGF_Tenascin PF18720.1 PIK52651.1 - 0.003 17.6 0.2 0.003 17.6 0.2 3.9 2 1 1 3 3 3 1 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK52652.1 - 5.6e-49 166.9 3.6 2.3e-38 132.2 0.9 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52652.1 - 4.9e-06 26.7 19.0 4.9e-06 26.7 19.0 3.7 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK52652.1 - 1.8e-05 24.6 5.3 1.8e-05 24.6 5.3 3.5 3 1 1 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK52652.1 - 0.0004 20.5 7.4 0.0004 20.5 7.4 4.2 6 0 0 6 6 6 1 EGF domain COLFI PF01410.18 PIK52652.1 - 0.00059 19.2 6.4 0.027 13.8 2.4 2.5 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain EGF_MSP1_1 PF12946.7 PIK52652.1 - 0.059 13.4 13.6 0.5 10.5 4.4 2.9 2 0 0 2 2 2 0 MSP1 EGF domain 1 EGF_Tenascin PF18720.1 PIK52652.1 - 0.17 11.9 0.1 0.17 11.9 0.1 4.4 2 2 1 3 3 3 0 Tenascin EGF domain TIL PF01826.17 PIK52653.1 - 9e-07 29.1 19.7 9e-07 29.1 19.7 3.1 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK52653.1 - 5.1e-06 26.4 4.8 5.1e-06 26.4 4.8 3.1 2 1 1 3 3 3 2 TILa domain EGF_3 PF12947.7 PIK52653.1 - 3.9e-05 23.7 3.2 3.9e-05 23.7 3.2 3.6 3 1 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK52653.1 - 0.00016 21.6 1.9 0.022 14.5 0.0 2.4 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_Tenascin PF18720.1 PIK52653.1 - 0.072 13.2 0.2 0.072 13.2 0.2 4.5 3 2 1 4 4 4 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK52654.1 - 4.3e-60 203.3 21.8 1.9e-52 178.3 13.3 3.0 2 1 1 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52654.1 - 0.005 17.1 11.7 0.005 17.1 11.7 2.7 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52654.1 - 0.013 15.7 0.4 0.013 15.7 0.4 3.2 3 0 0 3 3 3 0 EGF domain EB PF01683.18 PIK52654.1 - 5.7 7.3 17.8 0.19 12.0 7.1 3.0 1 1 1 2 2 2 0 EB module Fibrinogen_C PF00147.18 PIK52655.1 - 1.5e-36 126.3 0.8 1.7e-36 126.1 0.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK52656.1 - 2.2e-44 151.9 1.0 2.2e-44 151.9 1.0 1.7 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK52656.1 - 4.3e-06 26.8 7.8 4.3e-06 26.8 7.8 2.6 2 0 0 2 2 2 1 EGF domain TILa PF12714.7 PIK52656.1 - 0.00081 19.3 3.6 0.0029 17.5 3.6 2.0 1 0 0 1 1 1 1 TILa domain EGF_MSP1_1 PF12946.7 PIK52656.1 - 0.012 15.6 6.4 0.012 15.6 6.4 2.3 2 0 0 2 2 2 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK52656.1 - 2.2 8.7 13.5 0.32 11.4 8.2 2.4 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.7 PIK52656.1 - 3.6 7.6 11.8 0.37 10.8 6.2 2.4 2 1 0 2 2 2 0 Complement Clr-like EGF-like zf-C4 PF00105.18 PIK52658.1 - 9.7e-31 106.0 15.6 9.7e-31 106.0 15.6 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK52658.1 - 4.5e-28 98.2 1.1 1.1e-26 93.7 0.0 2.2 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Plavaka PF18759.1 PIK52658.1 - 0.085 12.1 1.3 0.14 11.3 1.3 1.3 1 0 0 1 1 1 0 Plavaka transposase DUF2529 PF10740.9 PIK52658.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) CAP_GLY PF01302.25 PIK52660.1 - 2.9e-17 62.4 0.0 4.9e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain RabGAP-TBC PF00566.18 PIK52660.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Sulfotransfer_2 PF03567.14 PIK52662.1 - 1.9e-09 37.8 0.0 3.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK52662.1 - 0.013 15.0 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain DUF5345 PF17280.2 PIK52662.1 - 0.17 11.8 0.1 0.42 10.6 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Ndc1_Nup PF09531.10 PIK52663.1 - 1.5 7.5 7.7 1.5 7.4 7.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SWIM PF04434.17 PIK52664.1 - 1.3e-07 31.1 2.9 3.2e-07 29.9 2.9 1.7 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_2 PF13639.6 PIK52664.1 - 2e-07 31.2 13.7 1.9e-06 28.1 7.5 3.8 4 0 0 4 4 3 2 Ring finger domain ZZ PF00569.17 PIK52664.1 - 5.9e-06 26.0 10.5 1.8e-05 24.5 10.5 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type FANCL_C PF11793.8 PIK52664.1 - 0.0025 18.0 8.2 0.031 14.5 5.1 2.8 2 0 0 2 2 2 1 FANCL C-terminal domain Rad50_zn_hook PF04423.14 PIK52664.1 - 0.0039 17.0 0.5 3.7 7.5 0.1 2.8 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-rbx1 PF12678.7 PIK52664.1 - 0.0051 17.1 0.3 0.0051 17.1 0.3 4.0 3 1 0 3 3 2 2 RING-H2 zinc finger domain RINGv PF12906.7 PIK52664.1 - 0.0065 16.6 12.5 0.61 10.3 7.3 2.9 2 0 0 2 2 2 2 RING-variant domain zf-ANAPC11 PF12861.7 PIK52664.1 - 0.014 15.4 4.3 0.014 15.4 4.3 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Sporozoite_P67 PF05642.11 PIK52664.1 - 0.06 11.4 1.0 0.082 11.0 1.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-C3HC4_2 PF13923.6 PIK52664.1 - 0.097 12.5 0.3 0.097 12.5 0.3 4.2 3 2 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-H2C2_2 PF13465.6 PIK52664.1 - 0.87 10.1 0.1 0.87 10.1 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-RING_UBOX PF13445.6 PIK52664.1 - 5.9 7.0 15.8 0.48 10.5 5.2 3.7 3 0 0 3 3 3 0 RING-type zinc-finger 7tm_1 PF00001.21 PIK52665.1 - 1.4e-09 37.7 24.4 7.4e-08 32.0 24.4 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK52667.1 - 0.0076 15.6 12.0 0.012 15.0 12.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_S10 PF00450.22 PIK52668.1 - 6.1e-49 167.6 0.0 4.4e-48 164.7 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase 7TM_transglut PF14402.6 PIK52669.1 - 0.018 14.5 1.2 0.042 13.3 0.8 1.7 2 0 0 2 2 2 0 7 transmembrane helices usually fused to an inactive transglutaminase NEMO PF11577.8 PIK52669.1 - 0.047 13.7 0.3 0.12 12.4 0.3 1.7 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO Phospholip_A2_2 PF05826.12 PIK52669.1 - 0.056 13.7 2.4 0.14 12.4 2.4 1.7 1 0 0 1 1 1 0 Phospholipase A2 MAT1 PF06391.13 PIK52669.1 - 0.23 11.3 3.8 0.46 10.3 3.8 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF4181 PF13789.6 PIK52669.1 - 0.62 10.4 3.2 1.3 9.4 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) ARPC4 PF05856.12 PIK52670.1 - 3.5e-81 270.7 10.0 4e-81 270.5 10.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.5 PIK52670.1 - 0.0056 16.8 0.1 0.01 16.0 0.1 1.4 1 0 0 1 1 1 1 Sm_like domain EF-hand_1 PF00036.32 PIK52671.1 - 2.7e-10 39.0 0.0 6.3e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK52671.1 - 5.7e-09 35.2 0.2 0.0021 17.8 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK52671.1 - 3.8e-07 29.3 0.0 0.00093 18.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK52671.1 - 2.5e-06 27.8 0.3 9.4e-05 22.8 0.3 2.6 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK52671.1 - 0.0005 19.8 0.0 0.0065 16.3 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK52671.1 - 0.0015 18.8 0.1 0.0023 18.2 0.1 1.3 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 PIK52671.1 - 0.029 14.6 0.1 0.79 10.0 0.1 2.4 1 1 0 1 1 1 0 Dockerin type I domain Ephrin_rec_like PF07699.13 PIK52672.1 - 1.6e-06 27.8 70.5 3.8e-05 23.3 5.1 8.9 5 3 3 8 8 8 7 Putative ephrin-receptor like Miga PF10265.9 PIK52673.1 - 8.1 5.3 7.1 16 4.4 7.1 1.4 1 0 0 1 1 1 0 Mitoguardin BTB_2 PF02214.22 PIK52674.1 - 1.3e-18 67.2 0.0 2.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 PIK52674.1 - 0.00062 19.8 0.0 0.00099 19.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Cyclin_N PF00134.23 PIK52675.1 - 3.3e-38 130.3 1.7 8e-38 129.1 0.3 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK52675.1 - 2.8e-26 91.9 1.7 1.7e-25 89.4 0.7 2.4 2 0 0 2 2 2 1 Cyclin, C-terminal domain Fib_alpha PF08702.10 PIK52675.1 - 0.08 13.1 0.5 0.08 13.1 0.5 2.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DAG1 PF05454.11 PIK52676.1 - 0.02 14.3 0.0 0.1 11.9 0.0 1.8 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) GerA PF03323.13 PIK52676.1 - 0.033 12.7 0.2 0.056 11.9 0.2 1.3 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein TMEM154 PF15102.6 PIK52676.1 - 0.033 14.1 1.6 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Orthoreo_P10 PF07204.11 PIK52676.1 - 0.075 13.0 0.6 0.17 11.9 0.6 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 MGC-24 PF05283.11 PIK52676.1 - 2.9 8.3 9.1 3.6 8.0 4.3 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Acyl-CoA_dh_1 PF00441.24 PIK52677.1 - 6.5e-42 143.3 3.7 3.6e-37 127.9 3.6 2.3 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK52677.1 - 2.8e-25 88.3 0.0 8.3e-25 86.8 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK52677.1 - 3.7e-24 85.6 0.3 2.1e-23 83.1 0.1 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK52677.1 - 2.1e-13 50.7 0.4 3.6e-12 46.7 0.3 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain ubiquitin PF00240.23 PIK52678.1 - 7.5e-15 54.5 0.0 8.7e-15 54.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 PIK52678.1 - 0.00017 21.3 0.0 0.0002 21.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK52678.1 - 0.0056 17.1 0.0 0.061 13.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK52678.1 - 0.05 14.0 0.0 0.054 13.8 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain PID_2 PF14719.6 PIK52679.1 - 1.6e-09 37.9 0.0 2.2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ig_2 PF13895.6 PIK52680.1 - 3.7e-07 30.4 4.3 4.9e-05 23.6 0.0 3.2 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK52680.1 - 1.9e-05 24.8 0.2 0.014 15.6 0.1 3.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain TMEM154 PF15102.6 PIK52680.1 - 0.00093 19.1 3.5 0.00093 19.1 3.5 3.8 2 1 2 4 4 4 1 TMEM154 protein family EphA2_TM PF14575.6 PIK52680.1 - 0.0021 18.9 0.1 0.0063 17.4 0.1 2.0 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ig_3 PF13927.6 PIK52680.1 - 0.0031 18.1 0.0 0.0031 18.1 0.0 4.4 4 1 0 4 4 3 1 Immunoglobulin domain Shisa PF13908.6 PIK52680.1 - 0.0048 17.2 0.6 0.0048 17.2 0.6 2.5 1 1 1 2 2 1 1 Wnt and FGF inhibitory regulator RIFIN PF02009.16 PIK52680.1 - 0.012 15.5 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 Rifin I-set PF07679.16 PIK52680.1 - 0.066 13.3 0.6 0.32 11.1 0.0 2.4 3 0 0 3 3 2 0 Immunoglobulin I-set domain Tmemb_9 PF05434.11 PIK52680.1 - 0.066 13.1 0.3 0.18 11.7 0.2 1.7 1 1 0 1 1 1 0 TMEM9 TRP PF06011.12 PIK52680.1 - 0.08 11.7 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF5527 PF17665.1 PIK52680.1 - 0.11 12.0 4.6 0.048 13.2 1.8 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5527) DUF4834 PF16118.5 PIK52680.1 - 0.11 13.4 1.0 0.56 11.2 1.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Ctr PF04145.15 PIK52680.1 - 0.21 12.2 1.1 0.46 11.1 0.1 2.2 1 1 1 2 2 2 0 Ctr copper transporter family Orf78 PF06024.12 PIK52680.1 - 0.23 11.8 1.7 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DUF5305 PF17231.2 PIK52680.1 - 1 8.7 9.4 0.23 10.8 2.7 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5305) Hamartin PF04388.12 PIK52680.1 - 1.6 7.3 9.4 2.3 6.8 9.4 1.1 1 0 0 1 1 1 0 Hamartin protein Tab2_like PF06485.11 PIK52683.1 - 0.073 12.6 0.2 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 Ribosomal_L10 PF00466.20 PIK52685.1 - 5.4e-18 65.0 0.0 9.5e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 PIK52685.1 - 8.2e-18 64.2 1.2 1.4e-17 63.4 0.2 1.9 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 PIK52685.1 - 3.9e-10 40.2 12.2 3.9e-10 40.2 12.2 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein DUF936 PF06075.12 PIK52685.1 - 0.16 10.8 0.1 0.22 10.4 0.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) TIP120 PF08623.10 PIK52686.1 - 6.4e-62 208.2 0.9 6.4e-62 208.2 0.9 1.9 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) Cnd1 PF12717.7 PIK52686.1 - 5.2e-07 29.9 3.2 7.5e-05 22.8 0.2 2.8 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK52686.1 - 1e-05 24.3 2.3 0.00036 19.2 0.5 2.8 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.6 PIK52686.1 - 3e-05 24.3 0.0 0.0031 17.9 0.0 3.0 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 PIK52686.1 - 4.5e-05 23.4 0.0 1.5 9.3 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 PIK52687.1 - 2.2e-07 29.8 1.1 0.056 12.0 0.2 3.7 3 1 0 3 3 3 2 Adaptin N terminal region MMS19_C PF12460.8 PIK52687.1 - 1.1e-06 28.1 11.7 7.4e-05 22.0 0.4 5.5 6 2 1 7 7 7 1 RNAPII transcription regulator C-terminal HEAT PF02985.22 PIK52687.1 - 1.7e-06 27.8 2.3 0.54 10.7 0.1 6.4 6 0 0 6 6 6 1 HEAT repeat UME PF08064.13 PIK52687.1 - 2.1e-06 27.6 0.1 0.15 12.0 0.0 4.5 3 1 1 4 4 4 1 UME (NUC010) domain DUF3385 PF11865.8 PIK52687.1 - 5.6e-06 26.3 0.4 0.0046 16.9 0.0 3.9 3 1 2 5 5 5 1 Domain of unknown function (DUF3385) MMS19_N PF14500.6 PIK52687.1 - 0.00041 20.0 0.1 5.1 6.6 0.0 4.9 3 2 1 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II Telomere_reg-2 PF10193.9 PIK52687.1 - 0.0014 19.1 0.1 0.059 13.8 0.0 3.3 3 0 0 3 3 3 1 Telomere length regulation protein V-ATPase_H_N PF03224.14 PIK52687.1 - 0.003 16.9 0.7 1.3 8.2 0.0 3.2 4 0 0 4 4 4 1 V-ATPase subunit H HEAT_EZ PF13513.6 PIK52687.1 - 0.0069 16.9 0.2 1.9e+02 2.7 0.0 6.4 6 2 2 8 8 8 0 HEAT-like repeat DRIM PF07539.12 PIK52687.1 - 0.014 13.7 0.1 0.91 7.8 0.0 3.1 1 1 1 2 2 2 0 Down-regulated in metastasis Sec7_N PF12783.7 PIK52687.1 - 0.026 14.4 4.0 0.5 10.2 0.3 3.4 3 1 1 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Neurochondrin PF05536.11 PIK52687.1 - 0.03 12.7 0.1 0.081 11.3 0.1 1.7 2 0 0 2 2 2 0 Neurochondrin DUF1981 PF09324.10 PIK52687.1 - 0.08 12.8 0.3 3.1 7.7 0.0 3.5 4 1 1 5 5 5 0 Domain of unknown function (DUF1981) RIX1 PF08167.12 PIK52687.1 - 0.12 12.1 5.8 0.64 9.7 0.1 3.9 3 2 0 3 3 3 0 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 PIK52687.1 - 0.41 10.7 3.1 44 4.1 0.0 4.5 6 1 0 6 6 6 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK52688.1 - 6.4e-06 26.5 0.0 1e-05 25.9 0.0 1.3 1 1 0 1 1 1 1 HEAT repeats TAF6_C PF07571.13 PIK52688.1 - 9.6e-05 22.6 0.1 0.0012 19.1 0.1 2.2 1 1 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 PIK52688.1 - 0.00011 22.3 0.9 0.00015 21.8 0.9 1.3 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 PIK52688.1 - 0.00014 21.9 0.1 0.004 17.3 0.0 2.8 3 0 0 3 3 3 1 HEAT repeat Adaptin_N PF01602.20 PIK52688.1 - 0.00024 19.8 0.6 0.00026 19.7 0.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 PIK52688.1 - 0.0021 18.5 0.0 0.12 12.9 0.0 2.4 2 0 0 2 2 2 1 HEAT-like repeat MOR2-PAG1_N PF14222.6 PIK52688.1 - 0.0085 15.1 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 Cell morphogenesis N-terminal GhoS PF11080.8 PIK52688.1 - 0.0097 15.9 0.0 0.025 14.5 0.0 1.7 1 1 0 1 1 1 1 Endoribonuclease GhoS VHS PF00790.19 PIK52688.1 - 0.011 15.6 0.5 0.022 14.6 0.2 1.6 1 1 0 1 1 1 0 VHS domain DRIM PF07539.12 PIK52688.1 - 0.015 13.7 0.2 0.033 12.5 0.2 1.6 1 1 1 2 2 2 0 Down-regulated in metastasis RTP1_C1 PF10363.9 PIK52688.1 - 0.019 15.2 0.2 0.024 14.8 0.2 1.2 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_C PF11698.8 PIK52688.1 - 0.025 14.7 2.1 0.085 13.0 0.6 2.0 1 1 1 2 2 2 0 V-ATPase subunit H UME PF08064.13 PIK52688.1 - 0.041 13.8 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 UME (NUC010) domain Arm PF00514.23 PIK52688.1 - 0.14 12.3 0.1 2.7 8.2 0.1 2.5 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 PIK52688.1 - 0.16 12.3 0.9 0.36 11.2 0.3 2.0 2 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Trypsin PF00089.26 PIK52689.1 - 1.6e-76 257.0 0.1 2.1e-76 256.6 0.1 1.1 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK52689.1 - 1.4e-05 25.2 8.1 3.7e-05 23.9 8.1 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 PIK52689.1 - 2.7e-05 24.5 0.0 6.1e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK52689.1 - 3.1e-05 24.9 0.0 7.9e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain CUB PF00431.20 PIK52689.1 - 0.0014 19.0 0.1 0.0042 17.4 0.0 1.8 2 0 0 2 2 2 1 CUB domain Neuroparsin PF07327.11 PIK52689.1 - 0.5 10.8 5.5 1.5 9.3 5.5 1.7 1 1 0 1 1 1 0 Neuroparsin RVT_1 PF00078.27 PIK52690.1 - 5e-17 62.2 0.0 7.2e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIG1 PF04548.16 PIK52692.1 - 2.6e-45 154.4 3.5 4.3e-45 153.7 3.5 1.3 1 0 0 1 1 1 1 AIG1 family CARD PF00619.21 PIK52692.1 - 7e-13 48.4 0.5 1.8e-12 47.1 0.1 1.9 2 0 0 2 2 2 1 Caspase recruitment domain MMR_HSR1 PF01926.23 PIK52692.1 - 1.6e-08 34.6 1.2 2.9e-08 33.8 0.3 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 PIK52692.1 - 3.6e-05 23.2 0.6 3.6e-05 23.2 0.6 1.7 2 0 0 2 2 2 1 Septin FeoB_N PF02421.18 PIK52692.1 - 0.00044 19.8 0.6 0.0011 18.5 0.2 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK52692.1 - 0.0017 18.3 0.8 0.0048 16.8 0.4 1.8 1 1 1 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 PIK52692.1 - 0.0023 17.3 0.0 0.0052 16.2 0.0 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 PIK52692.1 - 0.012 15.7 8.6 0.18 11.9 7.7 3.4 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 PIK52692.1 - 0.018 14.4 0.6 0.052 13.0 0.6 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 PIK52692.1 - 0.036 14.6 1.0 0.075 13.6 0.1 2.1 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 PIK52692.1 - 0.039 13.3 0.6 0.21 10.9 0.2 2.2 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region T2SSE PF00437.20 PIK52692.1 - 0.052 12.6 0.0 0.094 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 PIK52692.1 - 0.062 13.1 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3991 PF13154.6 PIK52692.1 - 0.1 13.0 0.5 0.88 10.0 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3991) ABC_tran PF00005.27 PIK52692.1 - 0.31 11.6 2.7 0.28 11.7 1.0 2.0 2 1 0 2 2 2 0 ABC transporter DUF87 PF01935.17 PIK52692.1 - 3.5 7.6 6.8 8.5 6.4 4.3 2.6 1 1 1 2 2 2 0 Helicase HerA, central domain AIG1 PF04548.16 PIK52693.1 - 3.1e-39 134.5 3.1 5.4e-39 133.7 3.1 1.4 1 0 0 1 1 1 1 AIG1 family CARD PF00619.21 PIK52693.1 - 5.4e-12 45.6 0.0 2.3e-11 43.6 0.0 2.1 1 0 0 1 1 1 1 Caspase recruitment domain MMR_HSR1 PF01926.23 PIK52693.1 - 2e-11 44.0 0.4 4.8e-11 42.8 0.4 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase CARD_2 PF16739.5 PIK52693.1 - 0.00048 20.1 0.0 0.0024 17.8 0.0 2.3 1 0 0 1 1 1 1 Caspase recruitment domain Dynamin_N PF00350.23 PIK52693.1 - 0.00067 19.8 5.0 0.089 12.8 0.4 3.3 2 1 2 4 4 4 2 Dynamin family Septin PF00735.18 PIK52693.1 - 0.00079 18.8 0.1 0.0019 17.5 0.1 1.6 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 PIK52693.1 - 0.0054 16.7 0.0 0.022 14.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 PIK52693.1 - 0.0078 15.6 0.1 0.043 13.2 0.0 2.2 3 0 0 3 3 3 1 FtsK/SpoIIIE family ABC_tran PF00005.27 PIK52693.1 - 0.0087 16.6 0.2 0.02 15.4 0.2 1.9 1 1 0 1 1 1 1 ABC transporter FeoB_N PF02421.18 PIK52693.1 - 0.012 15.2 0.1 0.029 13.9 0.1 1.8 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF4874 PF16173.5 PIK52693.1 - 0.016 14.9 0.3 0.36 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) Gtr1_RagA PF04670.12 PIK52693.1 - 0.032 13.6 0.3 0.075 12.4 0.1 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 PIK52693.1 - 0.1 12.3 0.4 0.28 11.0 0.1 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Microtub_bd PF16796.5 PIK52693.1 - 1 9.3 4.6 4.9 7.1 0.1 3.2 3 1 0 3 3 3 0 Microtubule binding tRNA_m1G_MT PF01746.21 PIK52695.1 - 5.6e-25 88.2 0.0 9e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Kelch_6 PF13964.6 PIK52695.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Kelch motif BicD PF09730.9 PIK52696.1 - 6.9e-164 547.1 86.3 1.2e-108 364.5 28.5 3.0 2 1 1 3 3 3 2 Microtubule-associated protein Bicaudal-D DUF1759 PF03564.15 PIK52696.1 - 0.0057 16.6 4.9 0.0057 16.6 4.9 4.5 5 1 0 6 6 6 2 Protein of unknown function (DUF1759) Flavi_glycoprot PF00869.20 PIK52696.1 - 0.0069 15.6 0.7 0.012 14.8 0.7 1.3 1 0 0 1 1 1 1 Flavivirus glycoprotein, central and dimerisation domains HALZ PF02183.18 PIK52696.1 - 0.014 15.6 0.3 0.014 15.6 0.3 8.6 9 1 1 10 10 10 0 Homeobox associated leucine zipper Mce4_CUP1 PF11887.8 PIK52696.1 - 0.45 9.9 4.0 5.2 6.4 1.0 2.9 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Acetyltransf_1 PF00583.25 PIK52697.1 - 6.4e-15 55.4 0.0 1.1e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK52697.1 - 4.2e-10 39.7 0.1 7.5e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK52697.1 - 5.6e-09 36.3 0.0 1.5e-08 34.9 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK52697.1 - 2e-07 30.9 0.0 3.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.6 PIK52697.1 - 0.0088 16.0 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 PIK52697.1 - 0.011 15.2 1.0 0.022 14.2 1.0 1.6 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 PIK52697.1 - 0.019 15.0 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 PIK52697.1 - 0.023 15.4 0.0 0.04 14.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 PIK52697.1 - 0.048 13.4 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ CDC45 PF02724.14 PIK52697.1 - 0.43 8.8 10.0 0.52 8.5 10.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_A_exo1 PF01612.20 PIK52698.1 - 1.1e-21 77.3 0.0 1.9e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease Uds1 PF15456.6 PIK52698.1 - 0.15 12.2 0.2 0.27 11.4 0.2 1.4 1 0 0 1 1 1 0 Up-regulated During Septation BBS1 PF14779.6 PIK52698.1 - 0.16 11.3 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 FHA PF00498.26 PIK52699.1 - 4.6e-11 42.9 0.0 1.3e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 FHA domain dsrm PF00035.26 PIK52699.1 - 5e-06 27.1 0.1 1.5e-05 25.6 0.1 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif RVT_1 PF00078.27 PIK52699.1 - 0.00049 19.7 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yop-YscD_cpl PF16697.5 PIK52699.1 - 0.0007 19.9 0.0 0.004 17.4 0.0 2.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Dicer_dimer PF03368.14 PIK52699.1 - 0.017 15.2 0.0 0.056 13.6 0.0 1.9 1 0 0 1 1 1 0 Dicer dimerisation domain DUF2465 PF10239.9 PIK52700.1 - 1.4e-90 303.8 16.4 3.7e-86 289.3 6.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2465) Spectrin PF00435.21 PIK52701.1 - 4.1e-10 40.1 42.9 6.4e-06 26.6 5.0 6.4 4 3 0 5 5 5 4 Spectrin repeat Baculo_PEP_C PF04513.12 PIK52701.1 - 0.01 15.9 23.1 2.4 8.2 1.5 6.3 4 3 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med29 PF11568.8 PIK52701.1 - 0.033 14.4 8.1 0.6 10.3 0.3 4.1 4 0 0 4 4 4 0 Mediator complex subunit 29 Mannitol_dh PF01232.23 PIK52701.1 - 0.31 11.2 3.0 7.4 6.7 0.3 3.5 2 1 0 3 3 3 0 Mannitol dehydrogenase Rossmann domain Laminin_II PF06009.12 PIK52701.1 - 0.68 9.9 28.9 1.4 8.9 0.8 6.3 4 3 1 5 5 5 0 Laminin Domain II DNA_photolyase PF00875.18 PIK52701.1 - 3.2 7.7 7.7 12 5.8 0.1 4.3 5 0 0 5 5 5 0 DNA photolyase NOG1_N PF17835.1 PIK52701.1 - 5 7.1 14.4 0.52 10.3 0.2 4.6 5 1 0 5 5 5 0 NOG1 N-terminal helical domain GIT_CC PF16559.5 PIK52701.1 - 5.4 7.0 12.8 2.3 8.2 0.1 5.0 5 0 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spectrin PF00435.21 PIK52702.1 - 7.3e-08 32.9 38.8 0.0098 16.4 0.1 5.8 3 2 0 5 5 5 3 Spectrin repeat DUF948 PF06103.11 PIK52702.1 - 0.00016 21.8 18.9 0.032 14.5 0.2 6.2 4 2 0 5 5 5 2 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 PIK52702.1 - 0.54 10.3 13.2 0.058 13.4 0.9 4.1 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus RUN PF02759.19 PIK52702.1 - 1.1 9.2 6.1 6 6.8 6.1 2.7 1 1 0 1 1 1 0 RUN domain DUF1902 PF08972.11 PIK52702.1 - 1.5 8.8 3.9 26 4.9 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1902) Hydrolase_3 PF08282.12 PIK52702.1 - 3.7 7.2 11.6 2.6 7.7 1.6 3.0 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase DASH_Duo1 PF08651.10 PIK52702.1 - 3.7 7.4 14.4 9.1 6.1 0.2 5.4 6 1 2 8 8 8 0 DASH complex subunit Duo1 Sec20 PF03908.13 PIK52702.1 - 4 7.4 9.7 37 4.3 0.8 4.7 3 2 1 4 4 4 0 Sec20 Mod_r PF07200.13 PIK52702.1 - 6.3 6.9 44.6 1.1 9.3 11.2 5.0 2 2 3 5 5 5 0 Modifier of rudimentary (Mod(r)) protein YtxH PF12732.7 PIK52702.1 - 6.7 7.3 19.0 12 6.5 0.2 6.0 3 2 1 4 4 4 0 YtxH-like protein DUF5340 PF17275.2 PIK52702.1 - 8.6 6.6 11.2 17 5.6 0.1 4.1 4 1 0 4 4 4 0 Family of unknown function (DUF5340) Spectrin PF00435.21 PIK52703.1 - 5.8e-09 36.4 15.8 5.4e-05 23.6 3.7 4.2 2 1 1 3 3 3 2 Spectrin repeat T3SSipB PF16535.5 PIK52703.1 - 0.0012 19.3 16.8 0.0031 18.0 8.0 3.2 2 1 1 3 3 3 1 Type III cell invasion protein SipB DUF948 PF06103.11 PIK52703.1 - 0.0014 18.8 8.6 20 5.5 1.1 5.2 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 PIK52703.1 - 0.012 16.1 13.2 2.4 8.7 1.0 4.9 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein Sec34 PF04136.15 PIK52703.1 - 0.027 14.3 14.3 2.4 8.0 3.3 3.8 2 2 1 3 3 3 0 Sec34-like family Vps5 PF09325.10 PIK52703.1 - 0.031 13.8 0.6 0.031 13.8 0.6 3.3 2 1 1 3 3 3 0 Vps5 C terminal like Exonuc_VII_L PF02601.15 PIK52703.1 - 0.051 13.1 9.1 0.57 9.7 5.1 2.4 1 1 1 2 2 2 0 Exonuclease VII, large subunit Phage_GP20 PF06810.11 PIK52703.1 - 0.053 13.3 0.2 0.053 13.3 0.2 3.9 3 1 2 5 5 4 0 Phage minor structural protein GP20 DUF713 PF05218.14 PIK52703.1 - 0.057 13.2 0.3 0.057 13.2 0.3 3.5 2 1 1 4 4 4 0 Protein of unknown function (DUF713) Spc7 PF08317.11 PIK52703.1 - 0.08 11.8 23.6 0.39 9.6 3.2 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 PIK52703.1 - 0.11 12.8 14.6 0.78 10.1 1.4 4.5 2 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 PIK52703.1 - 0.11 11.7 0.1 0.11 11.7 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF3837 PF12939.7 PIK52703.1 - 0.3 11.5 5.0 2.3 8.7 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3837) V_ATPase_I PF01496.19 PIK52703.1 - 0.58 8.0 6.1 0.44 8.4 4.5 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 PIK52703.1 - 0.66 10.7 14.2 0.82 10.3 1.3 3.5 1 1 2 4 4 4 0 Initiation control protein YabA FapA PF03961.13 PIK52703.1 - 1.3 7.6 10.5 0.7 8.4 0.7 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4665 PF15679.5 PIK52703.1 - 1.7 9.3 5.7 5.9 7.6 1.4 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) ZapD PF07072.11 PIK52703.1 - 1.9 8.2 10.2 3.4 7.4 0.7 3.2 2 1 1 4 4 4 0 Cell division protein Prefoldin_2 PF01920.20 PIK52703.1 - 2 8.4 22.3 0.86 9.6 0.2 4.9 2 1 3 5 5 5 0 Prefoldin subunit DUF724 PF05266.14 PIK52703.1 - 3 7.6 17.9 4.2 7.2 2.8 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF724) GAS PF13851.6 PIK52703.1 - 3.9 6.8 22.0 0.56 9.5 14.2 2.6 2 2 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med9 PF07544.13 PIK52703.1 - 4.8 7.3 13.2 0.63 10.2 1.4 3.7 3 1 1 4 4 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.12 PIK52703.1 - 5.4 7.1 14.4 3.5 7.7 2.4 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4446 PF14584.6 PIK52703.1 - 8.5 6.4 12.4 2.4 8.1 1.2 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF4446) DUF2203 PF09969.9 PIK52703.1 - 10 6.9 12.1 6.5 7.5 1.5 3.7 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) LRR_8 PF13855.6 PIK52704.1 - 2.5e-35 120.1 57.5 5.3e-11 42.1 1.7 6.1 2 2 4 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 PIK52704.1 - 3.5e-18 65.8 2.1 8.3e-09 35.5 0.7 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK52704.1 - 3.5e-14 52.7 39.4 0.00047 20.5 4.5 6.0 2 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK52704.1 - 9.5e-06 25.2 14.6 0.00082 18.9 5.5 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK52704.1 - 7.5e-05 22.8 34.0 0.022 15.3 0.2 8.9 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 PIK52704.1 - 0.078 13.1 40.4 1.8 8.8 0.1 9.3 9 0 0 9 9 9 0 Leucine Rich repeat Snapin_Pallidin PF14712.6 PIK52705.1 - 0.016 15.6 3.9 0.016 15.6 3.9 3.8 3 1 1 4 4 4 0 Snapin/Pallidin Cauli_AT PF03233.13 PIK52705.1 - 2.2 8.2 9.8 1.4 8.8 0.4 3.0 2 1 1 3 3 3 0 Aphid transmission protein Syntaxin_2 PF14523.6 PIK52705.1 - 3.4 8.1 19.0 10 6.6 6.3 4.1 2 1 1 3 3 3 0 Syntaxin-like protein Ntox28 PF15605.6 PIK52705.1 - 5.8 7.2 10.3 2.1 8.6 0.3 3.9 3 1 1 4 4 4 0 Bacterial toxin 28 Spectrin PF00435.21 PIK52706.1 - 2.5e-18 66.5 95.3 2.8e-08 34.2 1.6 11.1 6 2 5 12 12 12 6 Spectrin repeat TPR_MLP1_2 PF07926.12 PIK52706.1 - 0.0094 16.0 5.9 0.0094 16.0 5.9 10.3 5 2 5 10 10 10 2 TPR/MLP1/MLP2-like protein FlaG PF03646.15 PIK52707.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK52708.1 - 0.074 13.2 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK52710.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.6 1 1 0 1 1 1 0 FlaG protein FlaG PF03646.15 PIK52711.1 - 0.11 12.7 0.1 0.32 11.2 0.1 1.7 1 1 0 1 1 1 0 FlaG protein Spectrin PF00435.21 PIK52712.1 - 9.5e-06 26.0 26.0 0.0012 19.3 10.2 3.1 2 2 1 3 3 3 2 Spectrin repeat HPS3_N PF14761.6 PIK52712.1 - 0.0041 16.7 0.1 0.0063 16.1 0.1 1.3 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 VWA_2 PF13519.6 PIK52712.1 - 0.15 12.7 1.0 1.9 9.2 0.0 2.5 1 1 1 2 2 2 0 von Willebrand factor type A domain AAA-ATPase_like PF09820.9 PIK52712.1 - 1.3 8.4 5.4 0.46 9.9 1.8 1.8 2 0 0 2 2 2 0 Predicted AAA-ATPase DUF4407 PF14362.6 PIK52712.1 - 5.8 6.2 10.1 8.3 5.7 10.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spectrin PF00435.21 PIK52713.1 - 1.9e-52 176.2 125.9 4.5e-09 36.7 0.9 12.3 11 1 1 12 12 12 11 Spectrin repeat Zmiz1_N PF18028.1 PIK52713.1 - 0.003 17.8 7.6 2 8.8 0.2 5.3 4 0 0 4 4 4 2 Zmiz1 N-terminal tetratricopeptide repeat domain Trimer_CC PF08954.11 PIK52713.1 - 0.027 14.0 0.7 3.6 7.2 0.1 4.2 2 0 0 2 2 2 0 Trimerisation motif FAA_hydro_N_2 PF18288.1 PIK52713.1 - 0.077 13.4 42.1 0.85 10.1 0.1 10.9 9 3 2 12 12 12 0 Fumarylacetoacetase N-terminal domain 2 ALS_ss_C PF10369.9 PIK52713.1 - 0.11 12.7 0.1 0.39 11.0 0.1 1.9 1 0 0 1 1 1 0 Small subunit of acetolactate synthase DUF349 PF03993.12 PIK52713.1 - 0.15 12.3 0.1 0.15 12.3 0.1 8.5 8 2 1 9 9 9 0 Domain of Unknown Function (DUF349) DUF3848 PF12959.7 PIK52713.1 - 0.2 11.8 9.6 2 8.6 0.4 5.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3848) Spectrin PF00435.21 PIK52714.1 - 6.8e-26 90.8 23.5 1.9e-11 44.4 4.0 3.2 3 0 0 3 3 3 3 Spectrin repeat CK2S PF15011.6 PIK52714.1 - 0.014 15.3 2.7 0.014 15.3 2.7 3.4 2 2 1 3 3 3 0 Casein Kinase 2 substrate Fib_alpha PF08702.10 PIK52714.1 - 0.031 14.5 16.1 0.56 10.4 3.5 3.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DinB_2 PF12867.7 PIK52714.1 - 0.055 14.0 1.4 1.4 9.4 0.0 2.9 2 1 0 3 3 3 0 DinB superfamily BLOC1_2 PF10046.9 PIK52714.1 - 0.071 13.4 11.7 8.3 6.8 0.1 4.6 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 PIK52714.1 - 0.76 10.1 7.9 6.6 7.1 0.8 4.3 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2258 PF10015.9 PIK52714.1 - 1.5 9.0 5.6 40 4.4 0.3 3.7 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2258) ABC_tran_CTD PF16326.5 PIK52714.1 - 3.5 7.9 11.9 0.9 9.8 1.2 3.9 3 1 2 5 5 5 0 ABC transporter C-terminal domain BNIP2 PF12496.8 PIK52714.1 - 3.9 7.9 7.3 1.2 9.5 0.2 3.0 2 2 1 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF445 PF04286.12 PIK52714.1 - 5.3 6.8 11.7 1 9.1 7.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF445) RVT_1 PF00078.27 PIK52715.1 - 4.4e-19 68.9 0.0 6.3e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK52716.1 - 8.3e-20 70.7 0.5 1.6e-19 69.8 0.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK52716.1 - 1.7e-05 25.0 0.0 3.8e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK52716.1 - 0.0086 16.3 0.2 0.015 15.5 0.2 1.4 1 0 0 1 1 1 1 H2C2 zinc finger zf-C2H2 PF00096.26 PIK52718.1 - 0.004 17.5 2.3 0.013 15.9 2.3 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type CEND1 PF15677.5 PIK52718.1 - 1.1 9.8 7.0 2 9.0 6.8 1.5 1 1 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 zf-C2H2_4 PF13894.6 PIK52718.1 - 3 8.9 8.5 0.17 12.8 2.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK52718.1 - 3.4 8.1 8.2 1.2 9.5 4.4 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding CBM_5_12_2 PF14600.6 PIK52720.1 - 0.013 15.5 0.4 0.029 14.3 0.2 1.8 1 1 0 1 1 1 0 Cellulose-binding domain EGF_3 PF12947.7 PIK52720.1 - 4.3 7.6 11.4 1.5 9.0 1.5 3.5 3 0 0 3 3 3 0 EGF domain OSK PF17182.4 PIK52721.1 - 0.0013 18.0 0.3 0.0019 17.4 0.3 1.2 1 0 0 1 1 1 1 OSK domain C1-set PF07654.15 PIK52723.1 - 0.019 15.4 0.3 1.2 9.6 0.1 2.9 2 1 1 3 3 3 0 Immunoglobulin C1-set domain RVT_1 PF00078.27 PIK52724.1 - 7.6e-41 140.1 0.9 1.7e-40 138.9 0.9 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.17 PIK52724.1 - 6.4e-39 133.8 0.1 4.1e-28 98.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK52724.1 - 4e-14 52.6 0.0 1.8e-09 37.4 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain McyA_C PF12593.8 PIK52724.1 - 0.035 13.9 0.0 0.095 12.5 0.0 1.7 1 0 0 1 1 1 0 Microcystin synthetase C terminal NACHT PF05729.12 PIK52725.1 - 0.00062 19.7 0.0 0.0028 17.6 0.0 2.1 2 0 0 2 2 2 1 NACHT domain R3H PF01424.22 PIK52726.1 - 0.03 14.3 0.6 1.5 8.8 0.0 3.0 3 0 0 3 3 3 0 R3H domain Gamma_PGA_hydro PF05908.11 PIK52726.1 - 0.18 11.2 1.5 0.38 10.1 0.9 1.7 1 1 0 1 1 1 0 Poly-gamma-glutamate hydrolase GTP-bdg_M PF16360.5 PIK52726.1 - 0.25 11.9 4.4 0.32 11.6 0.2 2.4 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Endonuc_Holl PF10107.9 PIK52726.1 - 0.68 9.8 6.6 6 6.7 0.3 2.3 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase EST1 PF10374.9 PIK52726.1 - 2.9 8.5 7.5 5.4 7.7 7.3 1.8 1 1 0 1 1 1 0 Telomerase activating protein Est1 Ly-6_related PF06579.12 PIK52727.1 - 0.16 12.2 7.0 0.62 10.3 7.0 1.8 1 1 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein Ca_hom_mod PF14798.6 PIK52727.1 - 0.71 8.9 4.8 0.39 9.8 0.3 2.1 2 0 0 2 2 2 0 Calcium homeostasis modulator DUF2067 PF09840.9 PIK52728.1 - 0.011 15.4 0.1 0.015 14.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) ZT_dimer PF16916.5 PIK52728.1 - 0.18 12.0 0.1 0.32 11.2 0.1 1.4 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter ADH_zinc_N PF00107.26 PIK52729.1 - 2.8e-05 24.1 0.1 0.28 11.2 0.0 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase YflT PF11181.8 PIK52729.1 - 0.021 15.3 0.0 11 6.6 0.0 2.2 2 0 0 2 2 2 0 Heat induced stress protein YflT DUF465 PF04325.13 PIK52729.1 - 0.023 14.7 0.2 9.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Ly-6_related PF06579.12 PIK52729.1 - 0.031 14.5 9.0 0.81 9.9 0.4 2.7 2 1 0 2 2 2 0 Caenorhabditis elegans ly-6-related protein DUF4926 PF16277.5 PIK52729.1 - 0.053 12.9 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4926) FlxA PF14282.6 PIK52729.1 - 0.082 12.9 1.3 12 6.0 0.1 2.1 2 0 0 2 2 2 0 FlxA-like protein ANAPC15 PF15243.6 PIK52729.1 - 0.11 12.9 0.0 19 5.8 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 CLZ PF16526.5 PIK52729.1 - 0.19 12.1 2.3 16 5.9 0.2 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HicB_lk_antitox PF15919.5 PIK52729.1 - 0.21 11.7 0.8 13 5.9 0.0 2.8 2 2 1 3 3 3 0 HicB_like antitoxin of bacterial toxin-antitoxin system ecTbetaR2 PF08917.10 PIK52729.1 - 0.65 10.0 8.8 5.2 7.0 0.3 3.1 2 2 1 3 3 3 0 Transforming growth factor beta receptor 2 ectodomain QVR PF17064.5 PIK52729.1 - 0.77 10.0 10.5 7.2 6.9 0.1 3.1 2 1 0 2 2 2 0 Sleepless protein Activin_recp PF01064.23 PIK52729.1 - 1.1 10.3 15.0 2 9.6 1.0 2.9 2 1 0 2 2 2 0 Activin types I and II receptor domain Kazal_1 PF00050.21 PIK52730.1 - 0.046 13.7 3.8 0.12 12.4 3.8 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain RVT_1 PF00078.27 PIK52731.1 - 4e-16 59.2 0.1 5.2e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) XPC-binding PF09280.11 PIK52735.1 - 0.74 9.6 3.4 11 5.8 0.3 2.3 2 0 0 2 2 2 0 XPC-binding domain Rieske PF00355.26 PIK52735.1 - 0.78 9.7 7.3 2.1 8.4 0.4 3.1 3 0 0 3 3 3 0 Rieske [2Fe-2S] domain Ly-6_related PF06579.12 PIK52735.1 - 1.3 9.3 18.2 2.2 8.5 0.8 3.2 2 2 0 2 2 2 0 Caenorhabditis elegans ly-6-related protein Brix PF04427.18 PIK52736.1 - 1.6e-16 60.9 0.8 2e-16 60.7 0.8 1.1 1 0 0 1 1 1 1 Brix domain Atg14 PF10186.9 PIK52737.1 - 0.003 16.7 4.4 0.0036 16.4 4.4 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Uso1_p115_C PF04871.13 PIK52737.1 - 0.005 17.2 0.3 0.005 17.2 0.3 2.1 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region Sugarporin_N PF11471.8 PIK52737.1 - 0.024 14.6 1.2 0.059 13.3 1.2 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PEP-utilisers_N PF05524.13 PIK52737.1 - 0.053 13.7 1.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal ATG16 PF08614.11 PIK52737.1 - 0.059 13.6 10.1 0.11 12.7 10.1 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) V-SNARE PF05008.15 PIK52737.1 - 0.067 13.6 1.0 0.067 13.6 1.0 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus JAKMIP_CC3 PF16034.5 PIK52737.1 - 0.07 13.1 11.5 0.27 11.2 4.1 2.1 2 0 0 2 2 2 0 JAKMIP CC3 domain Phage_GPO PF05929.11 PIK52737.1 - 0.24 11.0 5.5 0.4 10.3 5.5 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Seryl_tRNA_N PF02403.22 PIK52737.1 - 0.27 11.5 12.2 0.073 13.3 1.7 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Mvb12 PF09452.10 PIK52737.1 - 1.7 9.1 12.7 6 7.4 3.5 2.3 1 1 1 2 2 2 0 ESCRT-I subunit Mvb12 DUF4407 PF14362.6 PIK52737.1 - 3.1 7.1 9.5 4.2 6.6 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ax_dynein_light PF10211.9 PIK52737.1 - 5.1 7.0 15.2 3.1 7.7 3.0 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain BST2 PF16716.5 PIK52737.1 - 6 7.5 15.3 0.92 10.1 4.3 2.3 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 PIK52737.1 - 7.1 6.7 22.5 1.2 9.2 7.6 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2064 PF09837.9 PIK52738.1 - 1.6e-27 95.8 0.0 2.7e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2064) Glycos_transf_2 PF00535.26 PIK52738.1 - 4.8e-16 59.0 0.0 1e-15 58.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 PIK52738.1 - 2e-08 34.4 0.0 7.7e-08 32.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 PIK52738.1 - 0.0003 20.4 0.0 0.0025 17.4 0.0 2.4 2 1 0 2 2 2 1 Glycosyltransferase like family 2 CofC PF01983.16 PIK52738.1 - 0.006 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Guanylyl transferase CofC like DUF3399 PF11879.8 PIK52740.1 - 1.7e-15 57.2 4.3 1.7e-15 57.2 4.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3399) Hamartin PF04388.12 PIK52740.1 - 1.6 7.3 13.7 2 7.0 13.7 1.0 1 0 0 1 1 1 0 Hamartin protein Ion_trans PF00520.31 PIK52741.1 - 1.1e-27 96.9 14.8 1.5e-27 96.4 14.8 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 PIK52741.1 - 1.6e-26 92.5 0.1 3.5e-26 91.4 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Shal-type PF11601.8 PIK52741.1 - 4.1e-11 42.2 11.0 6.8e-11 41.5 11.0 1.4 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal BTB_3 PF16017.5 PIK52741.1 - 0.00061 19.9 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 PIK52741.1 - 0.013 15.5 3.1 0.013 15.5 3.1 2.6 2 0 0 2 2 2 0 Ion channel PKD_channel PF08016.12 PIK52741.1 - 0.41 9.3 8.9 0.7 8.5 8.9 1.4 1 1 0 1 1 1 0 Polycystin cation channel Y_phosphatase PF00102.27 PIK52742.1 - 4.6e-139 461.7 1.7 5.9e-84 281.3 0.5 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK52742.1 - 3.1e-39 133.2 21.1 2e-11 44.1 1.0 5.5 6 0 0 6 6 5 4 Fibronectin type III domain Ig_3 PF13927.6 PIK52742.1 - 8.1e-05 23.2 0.3 0.0035 17.9 0.0 3.2 2 0 0 2 2 2 1 Immunoglobulin domain Interfer-bind PF09294.10 PIK52742.1 - 0.00038 20.7 6.2 3.4 8.0 0.1 4.2 4 0 0 4 4 4 3 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.20 PIK52742.1 - 0.0012 18.7 0.0 0.0038 17.0 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK52742.1 - 0.0059 16.7 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 Inositol hexakisphosphate I-set PF07679.16 PIK52742.1 - 0.016 15.3 0.1 0.14 12.2 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52742.1 - 0.016 15.5 1.5 0.063 13.6 0.0 2.8 4 0 0 4 4 3 0 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK52742.1 - 0.019 15.6 20.1 0.031 14.9 0.6 5.6 5 1 0 5 5 5 0 Purple acid Phosphatase, N-terminal domain Y_phosphatase3 PF13350.6 PIK52742.1 - 0.021 14.8 0.0 0.069 13.1 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family Ig_6 PF18452.1 PIK52742.1 - 0.069 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK52742.1 - 0.1 12.8 0.1 1.8 8.8 0.0 2.8 2 0 0 2 2 2 0 Immunoglobulin V-set domain Abhydrolase_6 PF12697.7 PIK52743.1 - 7.2e-10 39.8 0.0 7.8e-07 29.9 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK52743.1 - 1.2e-08 34.5 0.0 1.5e-06 27.7 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK52743.1 - 9.2e-07 28.8 0.0 0.019 14.7 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 PIK52743.1 - 0.0033 16.4 0.0 2.1 7.2 0.0 2.4 1 1 1 2 2 2 2 Chlorophyllase enzyme Chlorophyllase PF07224.11 PIK52743.1 - 0.12 11.4 0.4 6.9 5.6 0.0 2.7 1 1 2 3 3 3 0 Chlorophyllase DUF4953 PF16313.5 PIK52743.1 - 0.14 11.4 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 Met-zincin Abhydrolase_6 PF12697.7 PIK52744.1 - 2.4e-07 31.6 0.1 0.00018 22.2 0.1 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK52744.1 - 4.8e-07 29.3 0.3 0.0017 17.6 0.2 2.7 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK52744.1 - 2e-05 24.3 0.0 0.014 15.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 PIK52744.1 - 0.018 14.6 0.1 0.051 13.1 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family rve PF00665.26 PIK52745.1 - 3.6e-23 82.0 0.0 4.4e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52745.1 - 0.0031 17.2 0.0 0.0051 16.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK52745.1 - 0.011 16.2 0.0 0.015 15.8 0.0 1.3 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RT_RNaseH_2 PF17919.1 PIK52746.1 - 2.7e-37 126.8 0.1 5.8e-37 125.7 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52746.1 - 1.6e-33 115.1 0.1 3.1e-33 114.2 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52746.1 - 4.7e-31 108.0 0.0 7.9e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK52747.1 - 8.7e-09 35.8 0.0 1.4e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK52747.1 - 3.9e-08 33.8 0.1 6.7e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 PIK52747.1 - 2.7e-06 27.2 0.0 4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK52747.1 - 0.012 15.9 0.1 0.067 13.5 0.1 2.0 1 1 0 1 1 1 0 Retroviral aspartyl protease PNMA PF14893.6 PIK52748.1 - 0.0043 16.5 0.8 0.007 15.8 0.6 1.5 1 1 0 1 1 1 1 PNMA Med10 PF09748.9 PIK52748.1 - 0.058 13.4 0.6 0.33 10.9 0.1 2.1 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DUF5388 PF17363.2 PIK52748.1 - 0.15 12.3 0.1 1.7 8.9 0.0 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5388) Sulfotransfer_2 PF03567.14 PIK52749.1 - 1.6e-05 25.0 0.1 3.6e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family DUF1645 PF07816.11 PIK52749.1 - 0.091 13.3 0.7 0.12 13.0 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) PhdYeFM_antitox PF02604.19 PIK52751.1 - 0.069 13.0 0.0 0.35 10.7 0.0 2.2 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system SET PF00856.28 PIK52752.1 - 1.2e-07 32.3 0.5 1.2e-07 32.3 0.5 3.4 2 2 0 2 2 2 1 SET domain PCSK9_C1 PF18459.1 PIK52752.1 - 5e-05 23.4 2.3 11 6.3 0.1 4.7 5 0 0 5 5 5 3 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain DUF4426 PF14467.6 PIK52752.1 - 0.046 13.7 6.6 13 5.8 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4426) Con-6 PF10346.9 PIK52752.1 - 0.16 12.1 2.1 1.1e+02 3.0 0.1 3.8 3 0 0 3 3 3 0 Conidiation protein 6 PSRP-3_Ycf65 PF04839.13 PIK52752.1 - 0.89 9.8 2.6 1.4e+02 2.8 0.1 3.5 3 0 0 3 3 3 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Beta_elim_lyase PF01212.21 PIK52753.1 - 1.1e-92 310.5 0.2 1.3e-92 310.2 0.2 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 PIK52753.1 - 1.7e-10 40.6 0.0 2.2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 PIK52753.1 - 6.1e-05 22.1 0.1 8e-05 21.8 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 PIK52753.1 - 8.3e-05 22.0 0.1 0.00024 20.5 0.1 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 PIK52753.1 - 0.0022 16.6 0.0 0.003 16.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Ribosomal_L27 PF01016.19 PIK52754.1 - 9.2e-18 64.0 0.3 1.3e-17 63.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein RT_RNaseH PF17917.1 PIK52756.1 - 2.1e-31 108.3 0.1 4.5e-31 107.2 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK52756.1 - 6e-30 103.2 0.0 1.3e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52756.1 - 4.2e-24 85.3 0.0 7.1e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK52757.1 - 3e-23 82.3 0.0 4e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK52757.1 - 1.1e-05 25.1 0.1 2.5e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK52757.1 - 0.011 15.9 0.1 0.018 15.3 0.1 1.2 1 0 0 1 1 1 0 DDE domain zf-H2C2_2 PF13465.6 PIK52758.1 - 4e-73 238.8 88.8 4.9e-09 36.2 2.7 10.0 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52758.1 - 3.1e-39 131.3 79.1 6.7e-06 26.3 3.8 9.1 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52758.1 - 2e-35 118.4 73.0 0.00013 22.5 3.2 9.1 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK52758.1 - 1.6e-17 63.3 57.0 0.0034 17.6 1.2 9.2 8 1 1 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK52758.1 - 4.9e-14 51.8 47.9 0.041 13.8 0.3 9.5 9 1 0 9 9 9 7 zinc-finger of a C2HC-type PyrI_C PF02748.15 PIK52758.1 - 1.2e-13 50.7 44.4 0.31 11.0 0.3 9.1 9 0 0 9 9 9 8 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_1 PF00130.22 PIK52758.1 - 2.8e-09 36.7 34.9 0.19 11.6 1.5 7.4 1 1 8 9 9 9 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_6 PF13912.6 PIK52758.1 - 4e-08 33.1 71.6 0.066 13.2 2.6 10.2 9 1 0 9 9 9 5 C2H2-type zinc finger zf-AN1 PF01428.16 PIK52758.1 - 5e-08 33.0 49.1 1.8 8.8 0.3 9.2 8 1 1 9 9 9 3 AN1-like Zinc finger zf-C2H2_11 PF16622.5 PIK52758.1 - 2.8e-07 30.2 40.5 0.024 14.4 0.3 8.5 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-ribbon_3 PF13248.6 PIK52758.1 - 3.6e-06 26.2 22.7 5.7 6.5 0.0 8.9 9 0 0 9 9 9 0 zinc-ribbon domain C1_4 PF07975.12 PIK52758.1 - 2.9e-05 24.2 45.2 0.013 15.8 2.5 6.2 2 2 5 7 7 7 4 TFIIH C1-like domain zf-C2HE PF16278.5 PIK52758.1 - 0.00013 22.3 55.1 0.033 14.6 0.7 9.0 3 2 6 9 9 9 2 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK52758.1 - 0.0013 18.7 59.9 3.3 7.8 1.5 9.1 3 2 6 9 9 9 2 BED zinc finger zf_UBZ PF18439.1 PIK52758.1 - 0.003 17.1 37.9 2.3 7.9 0.1 8.8 9 0 0 9 9 9 3 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 PIK52758.1 - 0.0035 18.1 41.3 1.3 9.9 2.3 5.0 2 1 1 4 4 4 3 zinc-ribbon family zf-CHCC PF10276.9 PIK52758.1 - 0.0036 17.3 61.8 1.1 9.3 0.7 9.1 9 0 0 9 9 9 4 Zinc-finger domain zf-Di19 PF05605.12 PIK52758.1 - 0.0041 17.4 49.5 0.49 10.7 3.6 6.8 1 1 4 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding MBDa PF16564.5 PIK52758.1 - 0.011 15.9 18.9 8.9 6.6 0.1 7.5 1 1 7 8 8 8 0 p55-binding region of Methyl-CpG-binding domain proteins MBD zf-met PF12874.7 PIK52758.1 - 0.1 13.1 65.9 1.1 9.8 2.9 9.2 9 0 0 9 9 9 0 Zinc-finger of C2H2 type Glyco_hydro_2_C PF02836.17 PIK52758.1 - 0.11 11.5 17.0 1 8.4 1.1 3.7 1 1 3 4 4 4 0 Glycosyl hydrolases family 2, TIM barrel domain zf-C2H2_2 PF12756.7 PIK52758.1 - 0.18 12.2 52.9 1.8 8.9 0.7 8.8 1 1 8 9 9 9 0 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.8 PIK52758.1 - 0.18 12.1 38.2 0.9 9.9 1.0 5.0 3 1 3 6 6 6 0 zinc-finger-containing domain Zf_RING PF16744.5 PIK52758.1 - 0.44 10.7 38.4 25 5.1 0.3 8.7 1 1 8 9 9 9 0 KIAA1045 RING finger zf-FCS PF06467.14 PIK52758.1 - 0.83 9.6 50.5 1.4 8.9 0.4 9.0 3 1 6 9 9 9 0 MYM-type Zinc finger with FCS sequence motif YyzF PF14116.6 PIK52758.1 - 1 9.4 44.3 12 6.1 0.2 8.9 9 0 0 9 9 9 0 YyzF-like protein GAGA PF09237.11 PIK52758.1 - 2.4 8.0 21.1 4 7.3 1.1 5.2 1 1 1 5 5 5 0 GAGA factor zf-U1 PF06220.12 PIK52758.1 - 2.7 7.8 50.6 2.1 8.2 0.2 9.3 8 1 1 9 9 9 0 U1 zinc finger HNH PF01844.23 PIK52758.1 - 2.8 8.2 42.2 18 5.6 0.9 8.9 9 0 0 9 9 9 0 HNH endonuclease BolA PF01722.18 PIK52758.1 - 3.3 8.1 13.7 7.9 6.8 0.4 4.5 4 1 1 5 5 5 0 BolA-like protein Yippee-Mis18 PF03226.14 PIK52758.1 - 3.7 7.8 31.3 10 6.4 0.1 6.0 2 1 4 6 6 6 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Sgf11 PF08209.11 PIK52758.1 - 3.8 7.2 28.5 14 5.4 0.1 8.4 9 0 0 9 9 9 0 Sgf11 (transcriptional regulation protein) XPA_N PF01286.18 PIK52758.1 - 4.2 7.5 34.5 25 5.0 0.1 8.6 9 0 0 9 9 9 0 XPA protein N-terminal zinc_ribbon_9 PF14369.6 PIK52758.1 - 4.6 7.6 25.2 43 4.5 0.0 7.9 9 0 0 9 9 9 0 zinc-ribbon zf_C2H2_6 PF18450.1 PIK52758.1 - 7.1 6.4 36.5 16 5.3 0.3 8.8 9 0 0 9 9 9 0 Zinc Finger domain zf-H2C2_2 PF13465.6 PIK52759.1 - 1.3e-111 360.5 110.4 5.3e-10 39.3 2.5 13.1 13 0 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.26 PIK52759.1 - 1.6e-66 217.2 105.5 1.1e-06 28.8 3.6 12.2 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK52759.1 - 3.2e-51 167.5 93.8 0.00012 22.6 1.7 12.2 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK52759.1 - 2e-27 94.9 78.0 0.0051 17.1 0.6 12.1 12 0 0 12 12 12 11 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK52759.1 - 5.7e-23 80.3 47.0 0.0012 18.7 0.1 12.5 12 0 0 12 12 12 8 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK52759.1 - 2.4e-21 75.1 47.8 0.0012 18.5 0.3 11.6 12 0 0 12 12 12 6 zinc-finger C2H2-type PyrI_C PF02748.15 PIK52759.1 - 8e-18 64.1 75.6 0.16 11.9 0.6 12.6 12 1 1 13 13 13 12 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 PIK52759.1 - 2.2e-13 50.4 73.2 0.004 17.6 0.3 12.0 1 1 11 12 12 12 5 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 PIK52759.1 - 2.8e-12 46.3 101.2 0.00084 19.3 1.5 13.4 12 1 0 12 12 12 9 C2H2-type zinc finger zf-met PF12874.7 PIK52759.1 - 5.2e-10 39.4 92.0 0.055 13.9 2.2 12.4 12 1 0 12 12 12 7 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK52759.1 - 5.5e-10 38.8 36.8 1.5e-05 24.7 0.8 16.5 13 7 0 13 13 13 5 C2H2-type zinc-finger domain zf-BED PF02892.15 PIK52759.1 - 3.4e-09 36.6 73.8 0.03 14.4 1.5 12.2 1 1 11 12 12 12 5 BED zinc finger C1_4 PF07975.12 PIK52759.1 - 2.7e-08 33.9 61.5 0.014 15.6 2.3 8.5 2 1 5 8 8 8 4 TFIIH C1-like domain zf-AN1 PF01428.16 PIK52759.1 - 9.8e-08 32.0 69.7 2 8.6 0.2 12.3 10 2 2 12 12 12 1 AN1-like Zinc finger zf-Di19 PF05605.12 PIK52759.1 - 4.8e-07 30.0 65.6 0.18 12.1 3.7 8.9 2 1 9 11 11 11 8 Drought induced 19 protein (Di19), zinc-binding Glyco_hydro_2_C PF02836.17 PIK52759.1 - 7.6e-06 25.2 30.2 0.23 10.5 2.1 5.0 1 1 4 5 5 5 5 Glycosyl hydrolases family 2, TIM barrel domain zinc_ribbon_15 PF17032.5 PIK52759.1 - 3.9e-05 24.3 58.4 0.43 11.4 3.7 6.8 3 1 6 9 9 9 6 zinc-ribbon family DUF3506 PF12014.8 PIK52759.1 - 8.8e-05 22.5 5.8 10 6.1 0.3 6.7 4 3 2 6 6 6 0 Domain of unknown function (DUF3506) zf_UBZ PF18439.1 PIK52759.1 - 0.00024 20.6 53.5 0.39 10.3 0.2 11.8 12 0 0 12 12 12 3 Ubiquitin-Binding Zinc Finger zf-CHCC PF10276.9 PIK52759.1 - 0.0014 18.6 83.3 1.5 9.0 0.7 12.1 12 0 0 12 12 12 6 Zinc-finger domain GAGA PF09237.11 PIK52759.1 - 0.016 15.0 28.9 3.5 7.5 0.2 7.8 1 1 7 10 10 10 0 GAGA factor zinc_ribbon_9 PF14369.6 PIK52759.1 - 0.02 15.1 31.8 8.9 6.7 0.1 10.8 11 1 1 12 12 12 0 zinc-ribbon zf-C2H2_2 PF12756.7 PIK52759.1 - 0.048 14.0 75.5 1 9.7 0.7 11.5 1 1 10 11 11 11 0 C2H2 type zinc-finger (2 copies) BolA PF01722.18 PIK52759.1 - 0.11 12.8 22.0 7.3 7.0 0.2 6.2 5 1 2 7 7 7 0 BolA-like protein EKAL PF17986.1 PIK52759.1 - 0.19 11.8 33.5 22 5.2 0.1 10.0 1 1 11 12 12 12 0 EMP3-KAHRP-like N-terminal domain zf-U1 PF06220.12 PIK52759.1 - 0.23 11.3 68.1 7.4 6.4 0.1 12.4 12 0 0 12 12 12 0 U1 zinc finger DUF3268 PF11672.8 PIK52759.1 - 0.32 11.3 58.5 0.7 10.2 2.3 6.7 1 1 7 10 10 10 0 zinc-finger-containing domain Zf_RING PF16744.5 PIK52759.1 - 0.47 10.6 52.8 37 4.5 0.2 11.7 1 1 11 12 12 12 0 KIAA1045 RING finger Yippee-Mis18 PF03226.14 PIK52759.1 - 2.5 8.3 43.6 15 5.8 3.4 8.5 2 1 4 7 7 7 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HlyD PF00529.20 PIK52760.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.8 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS RVT_1 PF00078.27 PIK52761.1 - 5.3e-27 94.8 0.0 7.8e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK52762.1 - 1.5e-25 89.5 0.3 1.3e-24 86.4 0.1 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK52762.1 - 8.1e-23 80.9 0.0 1.8e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK52762.1 - 3.4e-15 55.9 3.1 2.4e-14 53.2 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK52762.1 - 4.8e-15 55.4 0.3 1.6e-14 53.7 0.1 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK52762.1 - 2.5e-05 24.0 0.1 7.6e-05 22.4 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK52762.1 - 0.04 14.1 0.1 0.085 13.1 0.1 1.4 1 0 0 1 1 1 0 DDE domain Y_phosphatase PF00102.27 PIK52763.1 - 4.5e-61 206.4 0.1 5.3e-60 202.9 0.1 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase RR_TM4-6 PF06459.12 PIK52763.1 - 0.008 16.0 1.0 0.012 15.5 1.0 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DSPc PF00782.20 PIK52763.1 - 0.014 15.2 0.8 0.021 14.6 0.0 1.8 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK52763.1 - 0.016 15.2 0.1 0.031 14.2 0.0 1.5 2 0 0 2 2 2 0 Tyrosine phosphatase family RXLR PF16810.5 PIK52763.1 - 0.044 14.2 0.5 0.077 13.4 0.5 1.3 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity SKG6 PF08693.10 PIK52763.1 - 0.055 12.9 0.2 0.099 12.1 0.2 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EIIBC-GUT_N PF03612.14 PIK52763.1 - 0.061 13.1 1.5 0.11 12.2 1.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Cytochrom_B558a PF05038.13 PIK52764.1 - 3.6e-53 179.9 0.2 3.9e-53 179.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit Cg6151-P PF10233.9 PIK52764.1 - 0.0069 16.7 8.8 0.026 14.9 8.8 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein CG6151-P TatC PF00902.18 PIK52764.1 - 0.03 14.1 1.5 0.042 13.7 1.5 1.3 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DUF2754 PF10953.8 PIK52764.1 - 0.085 13.1 0.5 0.2 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) TMEM72 PF16054.5 PIK52764.1 - 1.3 8.7 8.7 5.4 6.7 8.7 1.8 1 1 0 1 1 1 0 Transmembrane protein family 72 CDT1 PF08839.11 PIK52765.1 - 8.1e-52 176.0 7.7 1.8e-51 174.9 0.5 3.1 3 0 0 3 3 3 2 DNA replication factor CDT1 like CDT1_C PF16679.5 PIK52765.1 - 1.5e-28 99.0 4.0 2.3e-28 98.5 1.0 3.0 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain SH3_9 PF14604.6 PIK52766.1 - 1.1e-11 44.4 0.1 1.5e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK52766.1 - 4.6e-11 42.1 0.0 6.3e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK52766.1 - 8.5e-11 41.4 0.0 1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain HYR PF02494.16 PIK52767.1 - 1.8e-11 44.2 0.0 3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 HYR domain EGF PF00008.27 PIK52767.1 - 0.00031 21.0 6.1 0.00075 19.7 6.1 1.6 1 0 0 1 1 1 1 EGF-like domain Neurensin PF14927.6 PIK52767.1 - 0.02 14.6 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Neurensin EGF_2 PF07974.13 PIK52767.1 - 0.028 14.8 6.4 0.051 13.9 6.4 1.4 1 0 0 1 1 1 0 EGF-like domain Orthoreo_P10 PF07204.11 PIK52767.1 - 0.031 14.2 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 hEGF PF12661.7 PIK52767.1 - 0.081 13.6 6.0 0.088 13.5 3.7 2.3 2 0 0 2 2 2 0 Human growth factor-like EGF DUF3827 PF12877.7 PIK52767.1 - 0.14 10.5 0.2 0.24 9.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) HYR PF02494.16 PIK52768.1 - 4.7e-231 747.8 97.1 5.8e-25 87.4 2.7 12.0 12 0 0 12 12 12 12 HYR domain Maelstrom PF13017.6 PIK52768.1 - 0.039 13.6 0.0 6 6.5 0.0 2.3 2 0 0 2 2 2 0 piRNA pathway germ-plasm component Glyco_transf_28 PF03033.20 PIK52768.1 - 0.16 12.0 0.0 41 4.2 0.0 3.0 2 2 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain SH3_12 PF18129.1 PIK52768.1 - 0.16 12.1 8.6 11 6.3 0.1 4.6 4 0 0 4 4 4 0 Xrn1 SH3-like domain PA_decarbox PF05870.11 PIK52768.1 - 0.2 11.3 2.1 5.2 6.7 0.0 3.8 5 0 0 5 5 5 0 Phenolic acid decarboxylase (PAD) Cadherin_3 PF16184.5 PIK52768.1 - 1.3 9.0 25.1 7.6 6.6 0.1 8.4 9 0 0 9 9 9 0 Cadherin-like HYR PF02494.16 PIK52769.1 - 0 1824.2 279.5 1.4e-25 89.4 0.7 28.0 28 0 0 28 28 28 28 HYR domain Cu-oxidase_3 PF07732.15 PIK52769.1 - 0.0006 19.8 1.6 26 4.9 0.0 6.6 5 2 1 7 7 7 1 Multicopper oxidase PhnG PF06754.12 PIK52769.1 - 0.00092 19.2 8.9 14 5.6 0.0 9.0 12 0 0 12 12 12 1 Phosphonate metabolism protein PhnG PDGF_N PF04692.13 PIK52769.1 - 0.046 14.5 0.0 2.4e+02 2.6 0.0 4.7 5 0 0 5 5 5 0 Platelet-derived growth factor, N terminal region DUF5011 PF16403.5 PIK52769.1 - 0.071 13.2 49.2 63 3.8 0.0 21.1 27 0 0 27 27 27 0 Domain of unknown function (DUF5011) SH3_12 PF18129.1 PIK52769.1 - 0.68 10.1 18.2 23 5.2 0.1 7.0 7 0 0 7 7 7 0 Xrn1 SH3-like domain Cadherin_3 PF16184.5 PIK52769.1 - 5 7.2 64.3 27 4.8 0.0 19.8 23 0 0 23 23 23 0 Cadherin-like HYR PF02494.16 PIK52770.1 - 2.8e-97 319.1 40.1 1.2e-19 70.4 3.8 8.0 8 0 0 8 8 8 7 HYR domain EGF PF00008.27 PIK52770.1 - 4.7e-45 151.5 197.3 1.8e-07 31.3 7.6 14.8 13 0 0 13 13 13 12 EGF-like domain hEGF PF12661.7 PIK52770.1 - 3.4e-22 78.2 166.8 4.6e-05 23.9 2.8 17.0 15 2 0 15 15 15 10 Human growth factor-like EGF Kazal_2 PF07648.15 PIK52770.1 - 1.2e-11 44.6 16.3 4e-08 33.3 5.1 7.4 6 1 1 7 7 7 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK52770.1 - 2.5e-11 43.4 17.4 4.7e-07 29.7 9.4 4.0 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain EGF_2 PF07974.13 PIK52770.1 - 0.0023 18.3 8.5 0.0023 18.3 8.5 14.8 14 1 0 14 14 14 9 EGF-like domain HYR PF02494.16 PIK52771.1 - 3.2e-38 129.9 10.8 3.8e-26 91.2 4.9 2.0 2 0 0 2 2 2 2 HYR domain DUF565 PF04483.12 PIK52771.1 - 0.0016 19.0 0.0 3.4 8.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF565) 2H-phosphodiest PF08975.10 PIK52772.1 - 0.077 13.0 0.0 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1868) RT_RNaseH PF17917.1 PIK52773.1 - 4e-36 123.5 0.0 8.6e-36 122.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK52773.1 - 3.8e-32 110.3 0.0 1e-31 108.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52773.1 - 6.8e-26 91.2 0.1 1.2e-25 90.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TTL PF03133.15 PIK52774.1 - 7.8e-25 87.6 0.1 1.1e-24 87.1 0.1 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family TTL PF03133.15 PIK52775.1 - 2.8e-07 30.0 0.0 4e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Galactosyl_T PF01762.21 PIK52776.1 - 9.2e-47 159.4 0.0 1.5e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK52776.1 - 0.0073 15.8 0.0 0.018 14.5 0.0 1.8 2 1 0 2 2 2 1 Fringe-like ASH PF15780.5 PIK52777.1 - 5e-09 36.3 0.0 0.006 16.8 0.0 4.8 4 1 0 4 4 4 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 PIK52777.1 - 0.0067 16.7 0.2 2.2 8.6 0.1 3.9 3 1 0 3 3 3 1 Transmembrane protein 131-like ASH PF15780.5 PIK52778.1 - 8.6e-21 74.0 6.8 5.6e-06 26.5 0.0 5.6 5 2 0 5 5 5 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 PIK52778.1 - 6.4e-11 42.4 2.4 0.001 19.3 0.0 4.7 4 0 0 4 4 4 3 Transmembrane protein 131-like DUF1573 PF07610.11 PIK52778.1 - 9.8e-09 35.2 1.2 0.019 15.0 0.0 4.5 5 0 0 5 5 5 2 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 PIK52778.1 - 0.00051 19.9 0.4 0.67 9.8 0.0 3.1 2 1 1 3 3 3 2 MSP (Major sperm protein) domain PapD-like PF14874.6 PIK52778.1 - 0.0053 16.9 0.8 11 6.2 0.0 4.1 3 1 1 4 4 4 1 Flagellar-associated PapD-like MYCBPAP PF14646.6 PIK52778.1 - 0.011 14.7 0.6 1.9 7.3 0.0 2.8 2 1 1 3 3 3 0 MYCBP-associated protein family Gryzun-like PF12742.7 PIK52778.1 - 0.044 13.8 0.2 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 Gryzun, putative Golgi trafficking Fn3-like PF14310.6 PIK52778.1 - 0.095 12.8 0.0 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Fibronectin type III-like domain ASH PF15780.5 PIK52779.1 - 3.3e-08 33.6 0.1 0.3 11.3 0.0 4.4 4 1 0 4 4 4 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CbiD PF01888.17 PIK52779.1 - 0.013 14.9 0.6 0.019 14.3 0.6 1.2 1 0 0 1 1 1 0 CbiD MYCBPAP PF14646.6 PIK52779.1 - 0.015 14.3 0.3 0.022 13.7 0.3 1.2 1 0 0 1 1 1 0 MYCBP-associated protein family Motile_Sperm PF00635.26 PIK52779.1 - 0.039 13.8 0.1 1.9 8.3 0.0 2.9 3 0 0 3 3 3 0 MSP (Major sperm protein) domain IHABP4_N PF16174.5 PIK52779.1 - 0.68 10.5 11.8 1.2 9.8 11.8 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Hydin_ADK PF17213.3 PIK52780.1 - 2e-44 152.2 1.7 2e-44 152.2 1.7 6.0 5 2 1 6 6 6 2 Hydin Adenylate kinase-like domain ASH PF15780.5 PIK52780.1 - 8.2e-13 48.4 5.1 0.0028 17.8 0.0 8.5 10 0 0 10 10 10 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 PIK52780.1 - 4.4e-08 33.2 1.3 1.8 8.7 0.0 5.4 6 0 0 6 6 6 3 Flagellar-associated PapD-like DUF1573 PF07610.11 PIK52780.1 - 9.8e-08 31.9 4.7 2.8 8.0 0.0 8.2 10 1 0 10 10 10 2 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 PIK52780.1 - 1.1e-05 25.2 5.1 0.54 10.1 0.0 6.5 8 0 0 8 8 8 2 MSP (Major sperm protein) domain PapD_N PF00345.20 PIK52780.1 - 0.032 14.1 1.4 1.2 9.1 0.0 4.0 4 0 0 4 4 4 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain DUF4834 PF16118.5 PIK52780.1 - 0.24 12.4 0.0 0.24 12.4 0.0 4.7 6 0 0 6 6 6 0 Domain of unknown function (DUF4834) ASH PF15780.5 PIK52781.1 - 1.2e-08 35.1 0.2 0.0054 16.9 0.0 3.7 3 1 1 4 4 4 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 PIK52781.1 - 4.8e-06 26.7 0.0 0.013 15.6 0.0 3.0 3 0 0 3 3 3 2 Flagellar-associated PapD-like Motile_Sperm PF00635.26 PIK52781.1 - 0.00013 21.8 0.6 1.7 8.5 0.0 3.5 4 0 0 4 4 4 2 MSP (Major sperm protein) domain TMEM131_like PF12371.8 PIK52781.1 - 0.012 15.9 0.1 1.1 9.6 0.0 3.3 3 0 0 3 3 3 0 Transmembrane protein 131-like ASH PF15780.5 PIK52782.1 - 0.017 15.3 0.0 0.063 13.5 0.0 1.9 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Abhydrolase_1 PF00561.20 PIK52783.1 - 3.9e-28 98.8 0.1 1.5e-17 64.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK52783.1 - 1.7e-13 51.7 0.0 2.6e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK52783.1 - 3.2e-13 49.5 0.0 1.2e-11 44.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 PIK52783.1 - 0.00016 21.4 0.0 0.00065 19.4 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 PIK52783.1 - 0.00052 20.1 0.0 0.00095 19.3 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.21 PIK52783.1 - 0.0018 17.8 0.7 0.024 14.1 0.7 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 PIK52783.1 - 0.0032 17.4 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PGAP1 PF07819.13 PIK52783.1 - 0.033 13.9 0.0 6.4 6.4 0.0 2.2 1 1 1 2 2 2 0 PGAP1-like protein Thioesterase PF00975.20 PIK52783.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 Thioesterase domain Tctex-1 PF03645.13 PIK52784.1 - 1.3e-20 73.5 0.9 2.1e-20 72.9 0.9 1.3 1 0 0 1 1 1 1 Tctex-1 family DNA_pol3_alpha PF07733.12 PIK52784.1 - 0.026 14.1 0.8 0.066 12.8 0.8 1.6 1 1 1 2 2 2 0 Bacterial DNA polymerase III alpha NTPase domain DEAD_assoc PF08494.11 PIK52784.1 - 0.099 12.4 0.2 10 5.9 0.0 2.2 1 1 2 3 3 3 0 DEAD/H associated PBP PF01161.20 PIK52785.1 - 8.4e-16 58.5 0.2 1e-15 58.2 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PBP PF01161.20 PIK52786.1 - 3.3e-17 63.0 0.1 4.6e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF5111 PF17138.4 PIK52786.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5111) TFIID_20kDa PF03847.13 PIK52787.1 - 3e-35 120.5 1.8 3e-35 120.5 1.8 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 PIK52787.1 - 2.6e-05 24.4 0.1 6.6e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK52787.1 - 0.0053 17.1 0.1 0.0053 17.1 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK52787.1 - 0.0081 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 PIK52787.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit M16C_assoc PF08367.11 PIK52787.1 - 0.024 13.8 0.2 0.078 12.1 0.0 1.7 2 0 0 2 2 2 0 Peptidase M16C associated DUF4404 PF14357.6 PIK52787.1 - 0.36 11.5 8.1 4 8.1 0.5 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) cNMP_binding PF00027.29 PIK52788.1 - 3.1e-22 78.5 1.2 3.3e-13 49.5 0.0 3.9 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain zn-ribbon_14 PF16503.5 PIK52789.1 - 1.5e-18 65.9 3.6 1.5e-18 65.9 3.6 3.1 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 PIK52789.1 - 2.5e-16 59.9 0.0 3.7e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 PIK52789.1 - 0.0049 15.7 0.0 0.0097 14.7 0.0 1.4 1 1 0 1 1 1 1 tRNA methyl transferase TF_Zn_Ribbon PF08271.12 PIK52789.1 - 0.0094 15.4 0.9 0.0094 15.4 0.9 3.9 3 1 1 4 4 4 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 PIK52789.1 - 5 7.6 5.8 3.2 8.2 0.7 2.9 3 0 0 3 3 3 0 Restriction alleviation protein Lar Cupin_4 PF08007.12 PIK52790.1 - 3.9e-60 204.0 0.1 5.3e-60 203.5 0.1 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 PIK52790.1 - 2e-05 24.5 1.2 0.052 13.3 0.3 2.6 1 1 1 2 2 2 2 Cupin-like domain Cupin_1 PF00190.22 PIK52790.1 - 0.0024 17.5 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 PIK52790.1 - 0.0038 16.9 0.2 0.1 12.3 0.0 2.4 2 0 0 2 2 2 1 Cupin domain RNA_pol_3_Rpc31 PF11705.8 PIK52790.1 - 0.004 17.4 2.8 0.004 17.4 2.8 1.8 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 Sigma70_ner PF04546.13 PIK52790.1 - 0.057 13.3 3.2 0.14 12.0 3.2 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region DNA_pol_phi PF04931.13 PIK52790.1 - 0.33 9.0 7.8 0.47 8.5 7.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 PIK52790.1 - 0.38 10.4 5.2 0.093 12.4 1.1 1.9 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 PIK52790.1 - 0.74 10.2 9.9 1.7 9.1 9.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 PIK52790.1 - 1.1 8.5 6.8 1.9 7.7 6.8 1.3 1 0 0 1 1 1 0 NOA36 protein FAM184 PF15665.5 PIK52791.1 - 0.00044 20.1 13.4 0.00044 20.1 13.4 2.1 2 1 0 2 2 2 1 Family with sequence similarity 184, A and B Csm1_N PF18504.1 PIK52791.1 - 0.032 14.5 0.6 0.032 14.5 0.6 3.4 4 1 0 4 4 4 0 Csm1 N-terminal domain Endonuc-BglII PF09195.11 PIK52791.1 - 0.086 12.7 0.6 0.18 11.6 0.6 1.5 1 0 0 1 1 1 0 Restriction endonuclease BglII DUF4618 PF15397.6 PIK52791.1 - 0.79 9.1 17.3 0.094 12.1 12.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) MMS22L_N PF14910.6 PIK52793.1 - 2e-93 314.1 21.1 3.3e-93 313.4 21.1 1.3 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal MMS22L_C PF14911.6 PIK52793.1 - 4.6e-28 98.4 10.2 5.3e-20 71.8 3.1 3.1 2 1 1 3 3 3 2 S-phase genomic integrity recombination mediator, C-terminal Mus7 PF09462.10 PIK52793.1 - 4.5e-06 25.8 3.6 0.012 14.5 0.1 3.2 3 0 0 3 3 3 2 Mus7/MMS22 family TMEM135_C_rich PF15982.5 PIK52793.1 - 0.0093 16.6 0.6 11 6.6 0.0 3.2 3 0 0 3 3 3 2 N-terminal cysteine-rich region of Transmembrane protein 135 CRAL_TRIO_2 PF13716.6 PIK52793.1 - 0.07 13.3 1.3 1.1 9.4 0.1 2.9 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain LIP1 PF15904.5 PIK52793.1 - 0.29 11.5 2.0 7 7.1 0.0 3.4 3 0 0 3 3 3 0 LKB1 serine/threonine kinase interacting protein 1 Sulfotransfer_2 PF03567.14 PIK52794.1 - 3.7e-15 56.5 1.2 4.9e-15 56.1 1.2 1.2 1 0 0 1 1 1 1 Sulfotransferase family RRM_1 PF00076.22 PIK52795.1 - 9e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Coilin_N PF15862.5 PIK52795.1 - 0.082 12.7 0.0 0.082 12.7 0.0 4.4 1 1 3 4 4 4 0 Coilin N-terminus Pro_isomerase PF00160.21 PIK52796.1 - 6.3e-40 137.0 0.2 1e-39 136.3 0.2 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3657 PF12394.8 PIK52796.1 - 0.041 14.4 0.0 0.15 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein FAM135 PDZ PF00595.24 PIK52797.1 - 2.4e-15 56.6 1.0 4.9e-15 55.6 0.5 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK52797.1 - 3e-08 33.4 0.6 6.8e-08 32.2 0.6 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK52797.1 - 0.00017 21.9 0.3 0.00067 19.9 0.2 2.1 2 0 0 2 2 2 1 PDZ domain DIL PF01843.19 PIK52797.1 - 0.043 14.1 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 DIL domain Collagen PF01391.18 PIK52797.1 - 4.9 7.0 28.1 0.17 11.7 21.1 2.3 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) RA PF00788.23 PIK52798.1 - 3.4e-25 88.5 0.0 2.7e-13 50.4 0.0 2.6 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.19 PIK52798.1 - 8.1e-12 45.3 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 DIL domain MAS20 PF02064.15 PIK52798.1 - 0.11 12.6 4.3 0.075 13.1 1.8 2.0 2 0 0 2 2 2 0 MAS20 protein import receptor DnaJ PF00226.31 PIK52799.1 - 4.4e-16 58.8 0.8 4.4e-16 58.8 0.8 2.0 2 0 0 2 2 2 1 DnaJ domain MSC PF09402.10 PIK52799.1 - 0.13 11.7 13.1 0.17 11.3 13.1 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain LMBR1 PF04791.16 PIK52799.1 - 3.7 6.3 10.3 4.3 6.1 10.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RMI1_C PF16099.5 PIK52800.1 - 5.4e-24 84.7 0.2 1.6e-13 50.7 0.0 2.7 2 0 0 2 2 2 2 Recq-mediated genome instability protein 1, C-terminal OB-fold DOPA_dioxygen PF08883.11 PIK52800.1 - 0.11 12.7 0.0 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Dopa 4,5-dioxygenase family RMI1_N PF08585.12 PIK52801.1 - 2.2e-53 181.2 0.6 2.2e-53 181.2 0.6 2.5 2 1 1 3 3 3 1 RecQ mediated genome instability protein ATP_bind_1 PF03029.17 PIK52802.1 - 6.3e-87 291.3 0.2 7.4e-87 291.1 0.2 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 PIK52802.1 - 2e-05 24.6 0.1 0.0039 17.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 PIK52802.1 - 0.00015 20.9 0.0 0.00024 20.2 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 PIK52802.1 - 0.001 18.8 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 PIK52802.1 - 0.0012 18.9 0.0 0.0019 18.2 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 PIK52802.1 - 0.0035 17.9 0.2 0.011 16.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK52802.1 - 0.0039 17.5 0.0 0.012 15.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK52802.1 - 0.0067 16.2 0.0 0.0093 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 PIK52802.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SRP54 PF00448.22 PIK52802.1 - 0.019 14.6 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ArsA_ATPase PF02374.15 PIK52802.1 - 0.021 14.0 0.0 0.058 12.6 0.0 1.7 2 1 0 2 2 2 0 Anion-transporting ATPase CLP1_P PF16575.5 PIK52802.1 - 0.021 14.6 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_17 PF13207.6 PIK52802.1 - 0.027 14.9 0.2 0.071 13.5 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK52802.1 - 0.042 14.2 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 PIK52802.1 - 0.051 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 PIK52802.1 - 0.059 13.5 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK52802.1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK52802.1 - 0.07 13.5 0.0 0.15 12.4 0.0 1.7 1 1 0 1 1 1 0 RNA helicase cobW PF02492.19 PIK52802.1 - 0.085 12.4 0.0 0.47 10.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 PIK52802.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 PIK52802.1 - 0.16 11.9 0.1 0.4 10.6 0.1 1.6 1 0 0 1 1 1 0 NTPase Mg_chelatase PF01078.21 PIK52802.1 - 0.21 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PDEase_I PF00233.19 PIK52803.1 - 3.5e-60 203.7 2.8 5.9e-60 203.0 2.8 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 PIK52803.1 - 7.4e-27 94.6 0.0 5.8e-19 69.0 0.0 2.7 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 PIK52803.1 - 5.3e-16 59.2 0.0 2.2e-10 41.0 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 PIK52803.1 - 3.3e-09 37.2 0.0 3.5e-05 24.2 0.0 3.3 2 1 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 PIK52803.1 - 0.042 13.9 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor H_kinase_N PF12282.8 PIK52803.1 - 0.19 11.7 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 Signal transduction histidine kinase NAD_binding_6 PF08030.12 PIK52804.1 - 6.3e-26 91.4 0.0 1.1e-25 90.6 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 PIK52804.1 - 2.6e-25 88.6 0.1 1.7e-24 86.0 0.1 2.1 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 PIK52804.1 - 2.3e-21 76.2 2.8 4.6e-21 75.2 2.8 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 PIK52804.1 - 0.0048 17.2 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 PIK52804.1 - 0.11 13.2 0.0 0.49 11.1 0.0 2.2 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Arm PF00514.23 PIK52805.1 - 9.8e-88 285.8 19.6 6.2e-13 48.3 0.0 8.5 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 PIK52805.1 - 2.9e-23 82.1 4.0 9.2e-23 80.5 3.3 2.3 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 PIK52805.1 - 2.3e-22 78.3 1.2 4.3e-21 74.2 0.8 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 PIK52805.1 - 3.9e-22 78.3 4.4 1.5e-06 28.5 0.1 6.1 3 2 4 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.6 PIK52805.1 - 3.2e-20 72.3 0.2 5.1e-05 23.6 0.0 5.9 2 1 5 7 7 7 6 HEAT repeats HEAT PF02985.22 PIK52805.1 - 1.8e-18 65.0 8.6 0.0018 18.3 0.0 7.7 8 0 0 8 8 7 3 HEAT repeat Arm_2 PF04826.13 PIK52805.1 - 9.6e-06 25.2 0.1 0.021 14.3 0.1 3.2 2 1 0 2 2 2 2 Armadillo-like V-ATPase_H_C PF11698.8 PIK52805.1 - 0.00015 21.9 0.1 0.21 11.7 0.0 4.2 3 2 1 4 4 4 2 V-ATPase subunit H NopRA1 PF16201.5 PIK52805.1 - 0.00023 20.8 0.0 15 5.1 0.0 4.9 2 2 3 5 5 5 0 Nucleolar pre-ribosomal-associated protein 1 Adaptin_N PF01602.20 PIK52805.1 - 0.00025 19.7 0.2 0.0074 14.9 0.0 2.9 1 1 2 3 3 3 1 Adaptin N terminal region HEAT_PBS PF03130.16 PIK52805.1 - 0.00081 19.8 0.2 3.3 8.7 0.0 4.7 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat CTNNBL PF08216.11 PIK52805.1 - 0.0013 18.8 0.2 8.7 6.6 0.0 4.8 5 0 0 5 5 5 1 Catenin-beta-like, Arm-motif containing nuclear SEN1_N PF12726.7 PIK52805.1 - 0.011 13.9 0.2 0.13 10.4 0.0 2.4 3 0 0 3 3 3 0 SEN1 N terminal RICTOR_V PF14668.6 PIK52805.1 - 0.017 15.3 6.7 6.5 7.1 0.1 4.8 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 PIK52805.1 - 0.026 14.5 0.1 4.3 7.4 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.8 PIK52805.1 - 0.058 13.0 1.1 0.7 9.4 0.3 2.7 2 2 1 3 3 3 0 CLASP N terminal DUF3361 PF11841.8 PIK52805.1 - 0.18 11.8 4.4 4.8 7.1 0.2 3.9 3 2 0 4 4 4 0 Domain of unknown function (DUF3361) Cid2 PF09774.9 PIK52806.1 - 8.7e-15 55.5 6.5 3.5e-13 50.3 6.5 2.0 1 1 0 1 1 1 1 Caffeine-induced death protein 2 I_LWEQ PF01608.17 PIK52806.1 - 0.082 13.1 0.6 0.11 12.8 0.6 1.2 1 0 0 1 1 1 0 I/LWEQ domain Activator_LAG-3 PF11498.8 PIK52806.1 - 0.12 11.3 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Cas_Csn2 PF09711.10 PIK52806.1 - 0.14 11.8 1.7 2.2 7.9 1.7 2.0 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) PSI_PsaF PF02507.15 PIK52806.1 - 0.17 11.7 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III MRP-S31 PF15433.6 PIK52807.1 - 3.1e-76 257.1 8.3 3.9e-76 256.7 8.3 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 SH3_9 PF14604.6 PIK52808.1 - 6e-67 221.3 5.2 8.4e-14 51.2 0.1 6.4 6 0 0 6 6 6 5 Variant SH3 domain SH3_1 PF00018.28 PIK52808.1 - 3.3e-65 215.5 14.7 1.5e-13 50.2 0.2 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 PIK52808.1 - 1.9e-60 200.4 2.9 2e-12 46.6 0.0 5.6 5 0 0 5 5 5 5 Variant SH3 domain PH_13 PF16652.5 PIK52808.1 - 7.3e-54 181.8 0.4 7.3e-54 181.8 0.4 2.6 2 0 0 2 2 1 1 Pleckstrin homology domain RhoGEF PF00621.20 PIK52808.1 - 8.8e-36 123.8 1.5 8.8e-36 123.8 1.5 3.2 3 0 0 3 3 2 1 RhoGEF domain C2 PF00168.30 PIK52808.1 - 5.3e-20 71.6 0.0 1.6e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 C2 domain EF-hand_4 PF12763.7 PIK52808.1 - 6.3e-15 55.0 0.0 1.7e-12 47.2 0.0 2.6 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand PH PF00169.29 PIK52808.1 - 3.2e-06 27.6 0.0 1.1e-05 25.8 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 PIK52808.1 - 3.4e-05 23.7 0.0 0.00013 21.8 0.0 2.1 2 0 0 2 2 1 1 PH domain EF-hand_1 PF00036.32 PIK52808.1 - 0.00028 20.2 0.1 0.00079 18.8 0.1 1.9 1 0 0 1 1 1 1 EF hand PH_8 PF15409.6 PIK52808.1 - 0.057 13.7 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain EF-hand_8 PF13833.6 PIK52808.1 - 0.07 13.0 0.1 0.22 11.4 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK52808.1 - 0.079 12.9 0.2 0.39 10.8 0.0 2.3 2 0 0 2 2 1 0 EF-hand domain Neprosin PF03080.15 PIK52808.1 - 0.26 10.6 2.4 1.6 8.0 0.0 2.7 3 0 0 3 3 3 0 Neprosin PH_11 PF15413.6 PIK52808.1 - 5.7 7.4 7.2 1.6 9.2 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain OSCP PF00213.18 PIK52809.1 - 1.1e-47 162.3 2.3 1.5e-47 161.9 2.3 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Carn_acyltransf PF00755.20 PIK52809.1 - 0.056 12.1 0.6 0.09 11.4 0.3 1.3 1 1 0 1 1 1 0 Choline/Carnitine o-acyltransferase Sec20 PF03908.13 PIK52809.1 - 0.11 12.4 0.7 0.46 10.4 0.1 2.3 3 0 0 3 3 3 0 Sec20 Ribosomal_S6 PF01250.17 PIK52810.1 - 6.1e-15 55.3 0.0 9.4e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S6 DHC_N1 PF08385.12 PIK52811.1 - 2.9e-121 405.9 0.0 2.6e-118 396.1 0.0 2.6 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Tautomerase PF01361.21 PIK52811.1 - 0.12 12.4 1.0 4.8 7.2 0.1 3.1 3 0 0 3 3 3 0 Tautomerase enzyme DHC_N2 PF08393.13 PIK52812.1 - 7.9e-87 291.9 1.5 7.9e-87 291.9 1.5 1.9 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 FlgN PF05130.12 PIK52812.1 - 0.47 11.0 6.3 4 8.0 0.1 3.7 4 0 0 4 4 4 0 FlgN protein PWWP PF00855.17 PIK52814.1 - 1.3e-14 54.3 0.0 3.9e-14 52.8 0.0 1.9 1 0 0 1 1 1 1 PWWP domain MBD PF01429.19 PIK52814.1 - 0.093 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyl-CpG binding domain SBDS_C PF09377.10 PIK52815.1 - 0.0092 16.0 0.2 0.015 15.3 0.2 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain HU-DNA_bdg PF14848.6 PIK52815.1 - 0.072 13.1 0.1 0.61 10.1 0.0 2.5 2 0 0 2 2 2 0 DNA-binding domain Homeodomain PF00046.29 PIK52818.1 - 8.2e-11 41.6 1.0 1.5e-10 40.8 0.4 1.7 2 0 0 2 2 2 1 Homeodomain HTH_Crp_2 PF13545.6 PIK52818.1 - 0.034 14.1 0.4 2.4 8.2 0.1 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain PolyA_pol PF01743.20 PIK52820.1 - 3.7e-18 66.2 0.0 8e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 PIK52820.1 - 2.9e-12 46.2 0.0 8.8e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 PIK52820.1 - 0.00045 20.2 0.1 0.00087 19.3 0.1 1.7 1 1 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative Ras PF00071.22 PIK52821.1 - 2.1e-28 99.0 2.1 2.7e-28 98.6 2.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK52821.1 - 2.3e-13 50.4 0.2 4.9e-13 49.3 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK52821.1 - 3.8e-06 26.5 0.3 4.8e-06 26.1 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK52821.1 - 0.016 15.1 0.4 0.03 14.2 0.4 1.5 1 1 0 1 1 1 0 RsgA GTPase AKAP7_NLS PF10469.9 PIK52821.1 - 0.026 14.4 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain DDRGK PF09756.9 PIK52822.1 - 1.3e-59 201.0 39.0 1.3e-59 201.0 39.0 1.4 2 0 0 2 2 2 1 DDRGK domain FeoC PF09012.10 PIK52822.1 - 0.0029 17.6 0.3 0.87 9.7 0.0 2.5 2 0 0 2 2 2 2 FeoC like transcriptional regulator HTH_DeoR PF08220.12 PIK52822.1 - 0.0049 16.6 0.3 1.2 8.9 0.2 2.6 2 0 0 2 2 2 2 DeoR-like helix-turn-helix domain PA26 PF04636.13 PIK52822.1 - 0.16 10.8 7.4 0.19 10.6 7.4 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4661 PF15576.6 PIK52822.1 - 1.1 9.1 9.9 1.5 8.6 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) FAM60A PF15396.6 PIK52822.1 - 5.4 7.0 12.4 9.2 6.2 12.4 1.5 1 0 0 1 1 1 0 Protein Family FAM60A ALMT PF11744.8 PIK52822.1 - 6.5 5.5 11.2 8.9 5.0 11.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 PIK52822.1 - 9.6 4.2 12.6 11 4.0 12.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein rve PF00665.26 PIK52823.1 - 6.9e-06 26.2 0.0 1.5e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain UIM PF02809.20 PIK52824.1 - 3.6e-06 26.5 7.3 0.021 14.7 0.8 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif RAP80_UIM PF18282.1 PIK52824.1 - 0.0015 18.2 2.7 0.86 9.4 0.1 2.5 3 0 0 3 3 3 2 RAP80 N-terminal ubiquitin interaction motif PUF PF00806.19 PIK52824.1 - 0.14 11.9 0.0 29 4.6 0.0 2.6 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat TAF8_C PF10406.9 PIK52839.1 - 1.1 9.8 4.0 2.6 8.7 0.1 2.4 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term BLOC1_2 PF10046.9 PIK52840.1 - 2.7e-31 107.7 6.7 4.5e-31 107.0 6.7 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 T2SSF PF00482.23 PIK52840.1 - 0.01 15.8 0.1 0.014 15.3 0.1 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F Laminin_II PF06009.12 PIK52840.1 - 0.03 14.4 2.3 0.045 13.8 2.3 1.3 1 0 0 1 1 1 0 Laminin Domain II Exonuc_VII_L PF02601.15 PIK52840.1 - 0.044 13.4 2.0 0.053 13.1 2.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 PIK52840.1 - 0.046 14.2 1.2 0.072 13.6 0.1 1.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ParB PF08775.10 PIK52840.1 - 0.076 13.5 2.9 0.18 12.3 2.9 1.7 1 1 0 1 1 1 0 ParB family SKA1 PF07160.12 PIK52840.1 - 0.15 11.9 5.4 0.33 10.8 2.5 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF1451 PF07295.11 PIK52840.1 - 0.21 11.6 6.5 0.2 11.7 2.7 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain Jnk-SapK_ap_N PF09744.9 PIK52840.1 - 0.31 11.2 7.0 0.48 10.6 7.0 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Med9 PF07544.13 PIK52840.1 - 0.35 11.0 5.4 0.12 12.5 2.5 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0449 PF15136.6 PIK52840.1 - 1.4 9.4 8.0 7 7.2 8.0 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF3772 PF12607.8 PIK52840.1 - 4 7.3 5.2 13 5.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3772) HSNSD PF12062.8 PIK52841.1 - 4.1e-180 599.7 0.4 6.6e-180 599.0 0.4 1.3 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 PIK52841.1 - 9.4e-31 107.3 0.0 1.5e-30 106.5 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK52841.1 - 8.5e-10 39.4 0.1 0.00098 19.6 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family YccV-like PF08755.11 PIK52841.1 - 0.028 14.9 0.0 0.28 11.7 0.0 2.5 2 0 0 2 2 2 0 Hemimethylated DNA-binding protein YccV like 7tm_1 PF00001.21 PIK52842.1 - 1.7e-29 102.9 13.7 3.5e-27 95.4 13.7 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK52842.1 - 5.9e-08 32.4 12.6 3.2e-07 30.0 12.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK52842.1 - 0.00016 21.1 0.2 0.00016 21.1 0.2 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK52842.1 - 0.00057 19.6 7.6 0.00057 19.6 7.6 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx zf-met PF12874.7 PIK52843.1 - 2.7e-06 27.6 22.2 0.082 13.3 1.6 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK52843.1 - 0.00011 22.4 3.2 0.00011 22.4 3.2 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK52843.1 - 0.00058 20.2 10.1 0.02 15.3 1.0 3.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK52843.1 - 0.0068 17.1 30.5 0.03 15.2 3.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-RRPl_C4 PF17026.5 PIK52843.1 - 0.27 11.3 8.4 0.51 10.5 8.4 1.4 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2H2_jaz PF12171.8 PIK52843.1 - 0.33 11.3 24.5 0.068 13.5 3.6 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 PIK52843.1 - 1.1 9.0 9.8 1.6 8.4 1.7 3.0 2 1 1 3 3 3 0 MYST family zinc finger domain NPL PF17800.1 PIK52845.1 - 9.8e-14 51.8 0.0 1.1e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 Nucleoplasmin-like domain DUF2200 PF09966.9 PIK52846.1 - 0.084 13.0 0.1 2.2e+02 2.0 0.0 5.2 7 1 1 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2200) Peptidase_M10 PF00413.24 PIK52847.1 - 1.1e-49 168.3 0.0 1.7e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK52847.1 - 6.7e-46 154.0 16.3 1.5e-14 53.6 0.3 5.2 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.18 PIK52847.1 - 2.1e-05 24.7 0.3 7.6e-05 22.8 0.1 2.1 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 PIK52847.1 - 0.031 14.8 0.2 0.061 13.8 0.2 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 PIK52847.1 - 0.054 12.1 0.3 0.08 11.5 0.3 1.1 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M57 PF12388.8 PIK52847.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.9 PIK52847.1 - 0.11 11.4 1.5 0.14 11.1 0.3 1.7 2 0 0 2 2 2 0 Peptidase M66 WD40 PF00400.32 PIK52848.1 - 6.1e-45 150.3 27.0 3.2e-08 34.1 0.2 11.9 11 1 0 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK52848.1 - 4.7e-22 78.1 6.4 0.012 15.9 0.0 8.3 4 2 2 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK52848.1 - 3.9e-07 29.7 10.1 0.0071 15.7 0.5 5.0 2 1 3 5 5 5 3 WD40-like domain AAA_16 PF13191.6 PIK52848.1 - 3.2e-06 27.6 0.1 1.4e-05 25.5 0.0 2.2 3 0 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK52848.1 - 0.00018 21.8 0.1 0.003 17.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 PIK52848.1 - 0.0002 21.3 0.0 0.0005 20.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain DAP3 PF10236.9 PIK52848.1 - 0.0012 18.1 0.1 0.0054 15.9 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 BBS2_Mid PF14783.6 PIK52848.1 - 0.0023 18.0 1.3 3.3 7.8 0.1 5.1 3 2 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region AAA_30 PF13604.6 PIK52848.1 - 0.0035 17.1 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK52848.1 - 0.0089 16.4 0.0 0.027 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 PIK52848.1 - 0.0097 15.1 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain RuvB_N PF05496.12 PIK52848.1 - 0.024 14.4 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Nup160 PF11715.8 PIK52848.1 - 0.025 13.3 11.4 8.5 4.9 0.2 5.9 2 1 4 7 7 7 0 Nucleoporin Nup120/160 Filo_VP35 PF02097.15 PIK52848.1 - 0.087 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Filoviridae VP35 ResIII PF04851.15 PIK52848.1 - 0.096 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 PIK52848.1 - 0.14 11.6 0.0 0.39 10.1 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 PIK52848.1 - 0.2 11.8 0.2 0.81 9.8 0.1 2.2 2 0 0 2 2 1 0 AAA domain adh_short PF00106.25 PIK52849.1 - 2.4e-32 112.0 0.0 3.3e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK52849.1 - 1.1e-16 61.1 0.0 1.6e-16 60.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK52849.1 - 0.0047 16.9 0.0 0.007 16.3 0.0 1.2 1 0 0 1 1 1 1 KR domain PipA PF07108.11 PIK52849.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 PipA protein Arf PF00025.21 PIK52850.1 - 3.9e-46 156.7 0.0 4.4e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 PIK52850.1 - 5.8e-06 25.7 0.0 1.5e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 PIK52850.1 - 0.00024 20.7 0.0 0.00024 20.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK52850.1 - 0.00026 21.2 0.0 0.00034 20.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK52850.1 - 0.00086 18.8 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK52850.1 - 0.026 14.6 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sec23_trunk PF04811.15 PIK52851.1 - 9.5e-65 218.6 0.0 1.5e-64 217.9 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 PIK52851.1 - 2e-26 91.8 0.1 4e-26 90.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 PIK52851.1 - 1.2e-20 74.1 0.0 2e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 PIK52851.1 - 1.5e-14 53.8 4.7 3.8e-14 52.4 4.7 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 PIK52851.1 - 0.018 14.9 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Gelsolin repeat PHD_2 PF13831.6 PIK52851.1 - 4.6 6.9 4.9 1.4e+02 2.1 4.1 3.1 2 1 0 2 2 2 0 PHD-finger adh_short PF00106.25 PIK52852.1 - 4.1e-24 85.1 0.0 1.2e-16 60.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK52852.1 - 7.2e-19 68.3 0.0 1.3e-10 41.2 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK52852.1 - 5.7e-06 26.3 0.0 9.1e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK52853.1 - 4e-28 98.2 0.0 1.2e-19 70.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK52853.1 - 5.2e-20 72.0 0.0 1.5e-12 47.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK52853.1 - 4.6e-06 26.7 0.0 7.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK52853.1 - 0.0064 16.0 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1577 PF07614.11 PIK52853.1 - 0.097 11.7 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) Sulfotransfer_3 PF13469.6 PIK52854.1 - 0.0014 19.1 0.2 0.002 18.5 0.2 1.3 1 0 0 1 1 1 1 Sulfotransferase family UQ_con PF00179.26 PIK52855.1 - 1.4e-42 144.6 0.1 1.6e-42 144.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK52855.1 - 0.00045 19.9 0.0 0.00053 19.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 PIK52855.1 - 0.0015 18.8 0.0 0.002 18.4 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 PIK52855.1 - 0.03 14.2 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 UEV domain Tetraspanin PF00335.20 PIK52856.1 - 3.4e-27 95.7 13.0 3.8e-27 95.5 13.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Fez1 PF06818.15 PIK52858.1 - 0.0011 19.5 8.3 0.0011 19.5 8.3 5.2 1 1 2 4 4 4 1 Fez1 Filament PF00038.21 PIK52858.1 - 1.7 8.2 105.7 0.3 10.6 45.2 3.3 1 1 2 3 3 3 0 Intermediate filament protein APG17 PF04108.12 PIK52858.1 - 9.7 5.2 72.6 0.8 8.8 1.9 5.7 1 1 3 4 4 4 0 Autophagy protein Apg17 DUF3636 PF12331.8 PIK52859.1 - 0.036 13.9 0.1 0.11 12.4 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3636) STAG PF08514.11 PIK52859.1 - 0.79 9.7 2.7 41 4.1 0.1 3.2 3 0 0 3 3 3 0 STAG domain Laminin_G_3 PF13385.6 PIK52860.1 - 4.8e-05 23.5 0.5 0.00022 21.4 0.5 2.1 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Seipin PF06775.14 PIK52860.1 - 0.081 13.0 0.1 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 Putative adipose-regulatory protein (Seipin) Beach PF02138.18 PIK52861.1 - 4.7e-123 409.9 0.4 6.9e-123 409.4 0.4 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 PIK52861.1 - 2.7e-12 46.7 0.0 6.5e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 PIK52861.1 - 1.2e-09 38.6 4.4 1.6e-05 25.5 0.1 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF4800 PF16057.5 PIK52861.1 - 0.079 12.2 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) DUF1088 PF06469.11 PIK52861.1 - 0.14 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Gal_Lectin PF02140.18 PIK52862.1 - 7.1e-94 308.4 60.3 2.7e-16 59.7 1.7 9.2 9 0 0 9 9 8 8 Galactose binding lectin domain F5_F8_type_C PF00754.25 PIK52862.1 - 5.9e-59 197.7 12.2 6e-16 58.7 0.5 7.3 7 0 0 7 7 7 6 F5/8 type C domain Lectin_C PF00059.21 PIK52862.1 - 3.3e-31 108.2 5.3 8.4e-17 61.9 0.1 3.9 3 0 0 3 3 2 2 Lectin C-type domain Mucin2_WxxW PF13330.6 PIK52862.1 - 1.8e-14 54.3 0.7 1.8e-14 54.3 0.7 6.0 5 1 0 5 5 3 1 Mucin-2 protein WxxW repeating region TSP_1 PF00090.19 PIK52862.1 - 1.1e-12 47.9 23.7 6.1e-08 32.8 10.8 3.6 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_3 PF13927.6 PIK52862.1 - 9.8e-07 29.3 0.0 4.7e-06 27.1 0.0 2.3 1 0 0 1 1 1 1 Immunoglobulin domain UL45 PF05473.12 PIK52862.1 - 6.6e-06 25.9 14.4 0.013 15.1 0.6 3.8 3 1 0 3 3 3 2 UL45 protein, carbohydrate-binding C-type lectin-like I-set PF07679.16 PIK52862.1 - 7.7e-06 25.9 0.0 2.2e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK52862.1 - 0.00027 21.2 2.5 0.00044 20.5 0.0 2.8 3 0 0 3 3 2 1 Immunoglobulin domain ig PF00047.25 PIK52862.1 - 0.0048 17.0 0.3 0.04 14.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain DUF3395 PF11875.8 PIK52862.1 - 0.0054 16.6 0.6 3.9 7.3 0.0 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF3395) PAN_4 PF14295.6 PIK52862.1 - 5 7.1 11.2 0.098 12.6 0.6 3.8 3 0 0 3 3 3 0 PAN domain Laminin_G_3 PF13385.6 PIK52863.1 - 6.9e-14 52.3 1.2 6.9e-14 52.3 1.2 2.5 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily F5_F8_type_C PF00754.25 PIK52863.1 - 1.9e-12 47.4 0.3 1.9e-12 47.4 0.3 2.1 2 0 0 2 2 2 1 F5/8 type C domain TSP_1 PF00090.19 PIK52863.1 - 0.00011 22.4 4.0 0.00028 21.0 4.0 1.7 1 0 0 1 1 1 1 Thrombospondin type 1 domain Fibrinogen_C PF00147.18 PIK52863.1 - 0.00014 21.7 0.2 0.00037 20.4 0.1 1.7 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TSP_1 PF00090.19 PIK52864.1 - 1.1e-21 76.7 24.9 9e-12 45.0 6.6 3.0 2 1 1 3 3 3 2 Thrombospondin type 1 domain Lectin_C PF00059.21 PIK52864.1 - 2.4e-11 44.3 0.2 0.0001 23.0 0.5 3.6 2 1 0 2 2 2 2 Lectin C-type domain PAN_1 PF00024.26 PIK52865.1 - 2.5e-09 37.0 0.6 3.4e-09 36.5 0.6 1.2 1 0 0 1 1 1 1 PAN domain Fibrinogen_C PF00147.18 PIK52866.1 - 7.5e-15 55.3 1.5 8.1e-15 55.2 1.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK52867.1 - 2e-07 31.1 0.5 4.2e-07 30.0 0.0 1.8 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK52867.1 - 1.3e-05 25.3 8.4 1.3e-05 25.3 8.4 3.7 3 1 0 3 3 3 1 EGF domain TILa PF12714.7 PIK52867.1 - 0.00044 20.1 2.3 0.00044 20.1 2.3 3.0 2 1 1 3 3 3 1 TILa domain EGF_MSP1_1 PF12946.7 PIK52867.1 - 0.02 14.9 5.4 0.02 14.9 5.4 2.8 3 1 0 3 3 3 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK52867.1 - 2.2 8.7 15.7 0.55 10.6 8.3 2.9 2 1 0 2 2 2 0 EGF-like domain Mpt_N PF09176.11 PIK52868.1 - 0.074 13.2 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal Fibrinogen_C PF00147.18 PIK52869.1 - 7.4e-56 189.4 4.3 8.2e-56 189.3 4.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK52870.1 - 1.1e-14 54.8 4.2 2.3e-14 53.7 4.2 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Yae1_N PF09811.9 PIK52870.1 - 1.1e-06 28.2 6.1 0.17 11.6 0.0 5.5 4 2 2 6 6 6 4 Essential protein Yae1, N terminal Fibrinogen_C PF00147.18 PIK52871.1 - 5.7e-30 104.8 0.8 6.6e-30 104.6 0.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK52872.1 - 0.0047 16.9 3.9 0.0047 16.9 3.9 2.5 1 1 1 2 2 2 1 TILa domain Pox_A22 PF04848.13 PIK52873.1 - 0.0022 18.1 0.6 0.66 10.1 0.1 2.7 1 1 2 3 3 3 2 Poxvirus A22 protein TFIIE_alpha PF02002.17 PIK52873.1 - 0.0099 15.7 10.4 1.5 8.7 0.3 3.1 1 1 2 3 3 3 3 TFIIE alpha subunit VWD PF00094.25 PIK52873.1 - 0.11 12.8 4.8 0.23 11.7 1.7 2.1 1 1 1 2 2 2 0 von Willebrand factor type D domain Lipin_N PF04571.14 PIK52873.1 - 1.7 8.7 14.9 19 5.3 0.3 4.1 1 1 0 4 4 4 0 lipin, N-terminal conserved region Epimerase PF01370.21 PIK52874.1 - 6.2e-18 65.1 0.0 7.6e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK52874.1 - 3.3e-14 53.1 0.0 4.7e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 PIK52874.1 - 3.7e-12 45.9 0.0 4.5e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 PIK52874.1 - 1.9e-07 30.4 0.0 2.4e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 PIK52874.1 - 1.8e-05 24.0 0.0 0.00013 21.3 0.0 2.1 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 PIK52874.1 - 5.7e-05 22.4 0.2 0.0015 17.7 0.2 2.4 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK52874.1 - 0.0061 16.5 0.1 0.86 9.5 0.0 2.5 2 1 0 2 2 2 1 KR domain Ldh_1_N PF00056.23 PIK52874.1 - 0.01 15.9 0.1 0.014 15.5 0.1 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.20 PIK52874.1 - 0.052 13.7 0.0 0.074 13.2 0.0 1.2 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ECH_1 PF00378.20 PIK52875.1 - 1.9e-37 128.9 0.3 5.3e-36 124.2 0.3 2.1 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK52875.1 - 5e-12 46.0 1.3 1.1e-11 44.8 0.3 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase RPA_C PF08784.11 PIK52876.1 - 5.4e-18 65.6 1.3 1.3e-17 64.3 1.3 1.6 1 0 0 1 1 1 1 Replication protein A C terminal RMI2 PF16100.5 PIK52876.1 - 9.5e-05 22.2 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 tRNA_anti-codon PF01336.25 PIK52876.1 - 0.00037 20.4 0.0 0.00063 19.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Fibrinogen_C PF00147.18 PIK52877.1 - 6.8e-94 313.8 12.8 1.3e-55 188.6 6.5 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK52877.1 - 4.3e-07 29.8 7.5 4.3e-07 29.8 7.5 3.7 1 1 1 2 2 2 1 TILa domain TIL PF01826.17 PIK52877.1 - 2e-05 24.7 18.0 2e-05 24.7 18.0 3.5 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52877.1 - 0.00035 20.7 12.5 0.00035 20.7 12.5 5.0 5 1 0 5 5 5 1 EGF domain EGF_2 PF07974.13 PIK52877.1 - 0.019 15.3 10.6 0.019 15.3 10.6 5.5 5 1 0 5 5 5 0 EGF-like domain Syndecan PF01034.20 PIK52878.1 - 0.0015 18.4 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain TMEM132D_C PF15706.5 PIK52878.1 - 0.014 15.1 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Cadherin_C_2 PF16492.5 PIK52878.1 - 0.025 15.3 0.3 0.05 14.4 0.3 1.5 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal CBP_BcsF PF11120.8 PIK52878.1 - 1 9.5 3.7 9 6.5 3.7 2.1 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsF Fibrinogen_C PF00147.18 PIK52879.1 - 3.2e-50 171.0 4.2 4.1e-50 170.6 4.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK52880.1 - 4.4e-14 52.8 2.6 3.4e-06 27.0 0.1 3.7 2 1 2 4 4 4 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK52880.1 - 3.7e-11 42.8 11.9 3.7e-11 42.8 11.9 3.8 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK52880.1 - 2.1e-06 27.9 15.9 2.1e-06 27.9 15.9 3.9 2 1 2 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52880.1 - 0.027 14.7 14.9 0.027 14.7 14.9 4.5 2 2 2 4 4 4 0 EGF domain EGF_MSP1_1 PF12946.7 PIK52880.1 - 1 9.5 33.1 0.09 12.8 8.5 3.6 3 0 0 3 3 3 0 MSP1 EGF domain 1 TILa PF12714.7 PIK52881.1 - 3.3e-10 39.8 12.1 3.3e-10 39.8 12.1 3.8 2 1 2 4 4 4 1 TILa domain Fibrinogen_C PF00147.18 PIK52881.1 - 7.6e-08 32.4 0.0 1.2e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52881.1 - 1e-05 25.7 12.1 1e-05 25.7 12.1 3.4 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52881.1 - 0.0031 17.7 10.9 0.0031 17.7 10.9 4.2 2 2 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK52881.1 - 0.78 9.8 31.3 0.52 10.4 11.5 3.5 3 1 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK52882.1 - 5.6e-45 153.8 1.3 5.3e-25 88.5 0.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Flo11 PF10182.9 PIK52882.1 - 0.12 12.5 1.4 6.9 6.8 0.0 2.7 2 1 1 3 3 3 0 Flo11 domain Fibrinogen_C PF00147.18 PIK52883.1 - 2.3e-38 132.2 1.4 3.4e-38 131.7 1.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK52883.1 - 2.5e-11 43.4 11.9 2.5e-11 43.4 11.9 3.7 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK52883.1 - 1.7e-06 28.1 15.7 1.7e-06 28.1 15.7 3.4 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK52884.1 - 2.7e-74 249.7 6.8 2.7e-39 135.3 0.4 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK52884.1 - 1.3e-10 41.1 11.6 1.3e-10 41.1 11.6 3.9 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK52884.1 - 1.6e-06 28.3 16.6 1.6e-06 28.3 16.6 3.7 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK52884.1 - 0.0057 16.8 10.5 0.0057 16.8 10.5 4.4 3 3 1 4 4 4 1 EGF domain Fibrinogen_C PF00147.18 PIK52885.1 - 2.8e-17 63.3 1.6 3.8e-17 62.8 1.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52885.1 - 8.3e-06 26.0 12.5 1.4e-05 25.2 12.5 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK52885.1 - 0.055 13.5 5.7 0.097 12.7 4.6 2.1 1 1 0 1 1 1 0 MSP1 EGF domain 1 TILa PF12714.7 PIK52886.1 - 2.8e-10 40.0 12.0 2.8e-10 40.0 12.0 3.9 2 1 2 4 4 4 1 TILa domain Fibrinogen_C PF00147.18 PIK52886.1 - 9.9e-10 38.6 0.0 5.7e-07 29.6 0.1 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK52886.1 - 6.6e-07 29.5 15.3 6.6e-07 29.5 15.3 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK52886.1 - 1.3 9.2 32.8 0.46 10.6 11.5 3.8 3 1 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK52887.1 - 4.6e-22 78.9 10.7 4.6e-22 78.9 10.7 1.9 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK52888.1 - 4.1e-41 141.2 1.0 5.1e-41 140.9 1.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain HLH PF00010.26 PIK52889.1 - 1e-10 41.4 0.1 1e-10 41.4 0.1 2.7 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Trypan_PARP PF05887.11 PIK52890.1 - 0.00013 21.9 14.8 0.0002 21.4 14.8 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 PIK52890.1 - 0.023 15.2 11.6 0.035 14.6 11.6 1.2 1 0 0 1 1 1 0 TonB polyproline region Fz PF01392.22 PIK52890.1 - 0.031 14.9 0.2 0.063 13.9 0.2 1.5 1 0 0 1 1 1 0 Fz domain SPESP1 PF15754.5 PIK52890.1 - 0.37 9.9 4.1 0.59 9.3 4.1 1.3 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Fz PF01392.22 PIK52891.1 - 1.2e-104 344.7 63.3 5.9e-29 100.9 7.7 6.3 6 0 0 6 6 6 6 Fz domain zf-RING_11 PF17123.5 PIK52891.1 - 0.017 14.9 2.7 6 6.7 0.2 3.7 2 0 0 2 2 2 0 RING-like zinc finger Glypican PF01153.19 PIK52891.1 - 0.022 13.6 0.5 0.022 13.6 0.5 3.4 4 0 0 4 4 4 0 Glypican Fz PF01392.22 PIK52892.1 - 6.3e-21 75.1 1.3 9.5e-21 74.5 1.3 1.3 1 0 0 1 1 1 1 Fz domain Fz PF01392.22 PIK52893.1 - 1.8e-28 99.4 1.3 2.2e-28 99.1 1.3 1.1 1 0 0 1 1 1 1 Fz domain Fz PF01392.22 PIK52894.1 - 3.3e-31 108.2 12.9 1.4e-17 64.3 4.3 2.9 4 0 0 4 4 4 2 Fz domain IgGFc_binding PF17517.2 PIK52895.1 - 1.9e-35 122.6 3.3 3.3e-35 121.8 3.3 1.3 1 0 0 1 1 1 1 IgGFc binding protein SICA_C PF12879.7 PIK52895.1 - 0.017 15.1 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 SICA C-terminal inner membrane domain KBP_C PF12309.8 PIK52896.1 - 6.7e-112 374.5 2.7 6.7e-112 374.5 2.7 1.8 2 0 0 2 2 2 1 KIF-1 binding protein C terminal TAP42 PF04177.12 PIK52896.1 - 0.013 14.7 9.0 0.14 11.2 0.0 3.5 3 1 1 4 4 4 0 TAP42-like family TPR_7 PF13176.6 PIK52896.1 - 0.042 13.9 0.3 0.47 10.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5423 PF17461.2 PIK52896.1 - 0.16 10.8 0.1 0.3 9.9 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) EF-hand_6 PF13405.6 PIK52897.1 - 6.1e-11 41.3 1.6 0.003 17.3 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 PIK52897.1 - 7.6e-11 42.3 2.4 2.2e-06 28.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK52897.1 - 1.9e-10 39.5 4.3 0.0098 15.4 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 PIK52897.1 - 1.1e-05 25.7 0.4 0.00012 22.4 0.1 2.2 2 1 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 PIK52897.1 - 5.1e-05 23.0 2.7 0.31 10.9 0.2 3.5 2 1 0 3 3 3 3 EF-hand domain pair ACBP PF00887.19 PIK52898.1 - 1.1e-24 86.4 0.6 2e-24 85.6 0.6 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein SH3_9 PF14604.6 PIK52899.1 - 0.00042 20.1 0.4 0.00078 19.3 0.1 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK52899.1 - 0.00072 19.1 0.1 0.0011 18.5 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK52899.1 - 0.0012 18.5 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain zf-C2H2_4 PF13894.6 PIK52899.1 - 0.034 15.0 1.0 0.12 13.3 1.0 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger SH2 PF00017.24 PIK52900.1 - 6.4e-07 29.4 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 SH2 domain PKD PF00801.20 PIK52902.1 - 1.6e-47 159.2 46.6 5.9e-09 35.7 1.9 9.5 9 1 0 9 9 9 9 PKD domain VWD PF00094.25 PIK52902.1 - 0.0002 21.7 0.4 0.019 15.2 0.0 3.5 3 0 0 3 3 3 1 von Willebrand factor type D domain PKD_3 PF16820.5 PIK52902.1 - 0.57 10.0 11.1 6.1 6.7 0.1 4.8 4 0 0 4 4 4 0 PKD-like domain RT_RNaseH_2 PF17919.1 PIK52903.1 - 2.2e-21 75.7 0.0 7.2e-14 51.6 0.0 3.4 2 1 0 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK52903.1 - 1.2e-19 70.5 0.0 3.1e-19 69.2 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK52903.1 - 1.3e-16 60.8 0.1 2.8e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TIR_2 PF13676.6 PIK52903.1 - 0.00047 20.7 1.3 1.3 9.6 0.1 2.6 2 0 0 2 2 2 2 TIR domain Ins_P5_2-kin PF06090.12 PIK52903.1 - 0.02 14.3 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Inositol-pentakisphosphate 2-kinase PDZ PF00595.24 PIK52903.1 - 0.077 13.4 0.0 20 5.6 0.0 2.5 2 0 0 2 2 2 0 PDZ domain DUF3091 PF11291.8 PIK52903.1 - 0.088 13.0 0.1 25 5.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) DUF2709 PF10915.8 PIK52903.1 - 0.15 11.3 0.1 1.6 8.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2709) RVT_1 PF00078.27 PIK52904.1 - 1.7e-22 80.0 0.0 3.3e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PNMA PF14893.6 PIK52904.1 - 3.9e-10 39.6 1.4 3.9e-10 39.6 1.4 1.5 1 1 1 2 2 2 1 PNMA Retrotrans_gag PF03732.17 PIK52904.1 - 0.0068 16.7 0.1 0.049 13.9 0.1 2.4 1 1 1 2 2 2 1 Retrotransposon gag protein REJ PF02010.15 PIK52905.1 - 6e-23 81.4 0.0 7.9e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 REJ domain Pap_E4 PF02711.14 PIK52905.1 - 0.012 16.5 1.6 0.033 15.1 1.6 1.7 1 0 0 1 1 1 0 E4 protein PLAT PF01477.23 PIK52906.1 - 4.2e-13 49.9 0.1 8.2e-12 45.7 0.0 2.7 3 0 0 3 3 3 1 PLAT/LH2 domain GPS PF01825.21 PIK52906.1 - 3.9e-07 30.5 2.5 3.9e-07 30.5 2.5 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif TMEM126 PF07114.11 PIK52906.1 - 0.22 10.9 3.7 0.29 10.5 0.5 2.4 2 1 1 3 3 3 0 Transmembrane protein 126 Galactosyl_T PF01762.21 PIK52907.1 - 5.7e-22 78.5 0.2 1e-21 77.6 0.2 1.4 1 0 0 1 1 1 1 Galactosyltransferase MAGUK_N_PEST PF10608.9 PIK52907.1 - 0.67 10.4 4.7 1.6 9.2 4.6 1.6 1 1 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK Galactosyl_T PF01762.21 PIK52908.1 - 4.1e-18 65.9 0.0 5.1e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Pkinase_Tyr PF07714.17 PIK52909.1 - 2.4e-92 308.9 0.0 4.9e-92 307.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52909.1 - 8e-47 159.8 1.6 2.5e-46 158.2 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain SH2 PF00017.24 PIK52909.1 - 4.4e-13 49.1 0.6 5.8e-12 45.6 0.1 2.7 2 0 0 2 2 2 1 SH2 domain DUF4795 PF16043.5 PIK52909.1 - 0.005 16.5 2.9 0.005 16.5 2.9 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) FlaC_arch PF05377.11 PIK52909.1 - 4.4 7.8 5.5 2.3 8.7 1.2 2.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) OmpH PF03938.14 PIK52909.1 - 4.5 7.6 15.4 12 6.2 1.3 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FCH PF00611.23 PIK52910.1 - 0.0001 22.5 0.1 0.00019 21.7 0.1 1.4 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain ODC_AZ PF02100.17 PIK52911.1 - 3.7e-13 49.5 0.0 5.1e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Filamin PF00630.19 PIK52912.1 - 3.9e-10 40.5 0.7 1.1e-09 39.0 0.2 2.1 2 0 0 2 2 2 1 Filamin/ABP280 repeat Hexapep PF00132.24 PIK52913.1 - 3.3e-08 32.9 14.1 4.1e-05 23.1 0.2 4.5 4 1 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) TPD PF14811.6 PIK52913.1 - 0.096 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif Hexapep_2 PF14602.6 PIK52913.1 - 0.14 12.0 10.9 0.22 11.3 0.3 3.4 2 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase PH PF00169.29 PIK52914.1 - 5.1e-18 65.5 0.5 9.5e-18 64.7 0.5 1.5 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 PIK52914.1 - 2.5e-10 39.9 0.1 5.2e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK52914.1 - 6.3e-09 35.3 0.2 1.6e-08 34.0 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK52914.1 - 9.2e-08 31.8 0.4 2.3e-07 30.6 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_9 PF15410.6 PIK52914.1 - 2.3e-06 28.0 0.3 1.9e-05 25.0 0.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 PIK52914.1 - 3.6e-05 24.1 0.3 9.7e-05 22.7 0.3 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 PIK52914.1 - 0.006 16.8 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.32 PIK52915.1 - 2.8e-27 92.2 15.6 7.7e-08 31.4 0.5 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 PIK52915.1 - 8.5e-26 90.2 12.9 2.6e-14 53.4 2.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK52915.1 - 7.1e-24 81.7 11.3 3.9e-07 29.5 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 PIK52915.1 - 1.4e-18 66.5 14.3 3.2e-11 42.9 0.6 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 PIK52915.1 - 1.7e-12 46.2 12.2 6.2e-05 22.3 0.4 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 PIK52915.1 - 4.4e-09 36.5 1.5 0.00046 20.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 PIK52915.1 - 2.6e-05 24.1 5.3 0.015 15.3 0.3 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 PIK52915.1 - 0.0021 18.0 2.0 0.47 10.4 0.0 3.8 1 1 3 4 4 4 1 Caleosin related protein EF-hand_14 PF17959.1 PIK52915.1 - 0.0071 16.7 3.7 0.63 10.4 0.2 2.8 1 1 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 PIK52915.1 - 0.013 15.8 5.4 0.36 11.2 1.4 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 PIK52915.1 - 0.015 15.1 1.8 1.3 8.8 0.9 2.1 2 0 0 2 2 2 0 SurA N-terminal domain UPF0231 PF06062.11 PIK52915.1 - 0.048 13.9 1.2 0.17 12.1 1.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) Relaxase PF03432.14 PIK52915.1 - 0.27 10.8 6.2 2.3 7.7 6.2 2.0 1 1 0 1 1 1 0 Relaxase/Mobilisation nuclease domain LPD26 PF18842.1 PIK52915.1 - 0.33 10.9 1.7 13 5.9 0.0 2.8 3 0 0 3 3 3 0 Large polyvalent protein associated domain 26 MgtE_N PF03448.17 PIK52915.1 - 0.39 11.4 4.3 0.45 11.1 0.2 2.6 1 1 2 3 3 3 0 MgtE intracellular N domain Homeodomain PF00046.29 PIK52916.1 - 4.7e-22 77.6 8.7 1.2e-21 76.3 8.7 1.7 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 PIK52916.1 - 0.005 16.6 0.7 0.011 15.4 0.7 1.6 1 0 0 1 1 1 1 QLQ STAT_bind PF02864.15 PIK52917.1 - 1.3e-48 165.0 1.1 1.3e-48 165.0 1.1 2.3 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.20 PIK52917.1 - 4.3e-43 147.2 24.7 7.4e-43 146.4 24.7 1.4 1 0 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.24 PIK52917.1 - 1.2e-11 44.6 0.0 4.1e-11 42.8 0.0 2.0 1 0 0 1 1 1 1 SH2 domain STATa_Ig PF18214.1 PIK52917.1 - 0.0002 21.4 0.2 0.0002 21.4 0.2 2.4 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain DUF2379 PF09543.10 PIK52917.1 - 0.048 13.8 0.0 0.3 11.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) Porphyrn_cat_1 PF18206.1 PIK52917.1 - 0.94 10.1 7.6 2.5 8.8 7.6 1.7 1 0 0 1 1 1 0 Porphyranase catalytic subdomain 1 LRR_8 PF13855.6 PIK52918.1 - 2.4e-37 126.5 29.5 9.5e-12 44.5 0.7 4.6 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK52918.1 - 4.7e-15 55.4 37.8 0.00035 20.9 0.5 6.4 4 2 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK52918.1 - 4.6e-11 42.8 0.1 0.0017 18.3 0.0 3.2 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK52918.1 - 6.6e-08 32.3 11.6 5.7e-05 22.7 0.8 2.7 2 1 1 3 3 3 3 Leucine-rich repeat LRRNT PF01462.18 PIK52918.1 - 5.1e-07 29.2 4.5 5.1e-07 29.2 4.5 2.6 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain I-set PF07679.16 PIK52918.1 - 1.2e-06 28.5 0.0 2.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK52918.1 - 0.0016 18.6 0.1 0.0059 16.8 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 PIK52918.1 - 0.0039 17.5 31.5 1.1 10.1 0.3 9.7 10 2 0 10 10 9 2 Leucine Rich Repeat Ig_2 PF13895.6 PIK52918.1 - 0.0076 16.6 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK52918.1 - 0.05 14.2 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Gram_pos_anchor PF00746.21 PIK52918.1 - 0.31 11.0 2.8 0.22 11.5 0.5 2.0 2 0 0 2 2 2 0 LPXTG cell wall anchor motif LRR_6 PF13516.6 PIK52918.1 - 0.71 10.1 36.1 2.8 8.2 0.1 10.0 11 1 0 11 11 11 0 Leucine Rich repeat LRR_8 PF13855.6 PIK52919.1 - 4.7e-32 109.5 32.5 9e-16 57.4 5.0 2.9 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK52919.1 - 1.1e-10 41.5 12.1 1.7e-07 31.4 0.4 3.8 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK52919.1 - 5e-09 36.2 4.7 8.2e-09 35.5 4.7 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK52919.1 - 3.8e-05 23.3 0.7 5.3e-05 22.8 0.7 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRRNT PF01462.18 PIK52919.1 - 0.00012 21.6 1.4 0.00023 20.7 1.4 1.4 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK52919.1 - 0.00021 21.4 12.2 0.63 10.8 0.2 5.0 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK52919.1 - 0.02 14.9 5.9 15 6.0 0.1 4.7 4 0 0 4 4 4 0 Leucine Rich repeat DUF1358 PF07096.11 PIK52920.1 - 7.3e-23 80.8 1.7 9.2e-23 80.4 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) Phage_holin_3_6 PF07332.11 PIK52920.1 - 0.36 10.9 2.9 3.8 7.6 0.3 2.1 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DHHC PF01529.20 PIK52921.1 - 9.9e-28 96.9 28.5 5.3e-27 94.5 17.0 3.0 2 1 1 3 3 3 2 DHHC palmitoyltransferase Reticulon PF02453.17 PIK52921.1 - 0.17 11.9 2.8 0.52 10.3 2.8 1.8 1 1 0 1 1 1 0 Reticulon Phage_holin_3_6 PF07332.11 PIK52921.1 - 1.4 9.0 5.8 0.64 10.1 0.1 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FMN_dh PF01070.18 PIK52922.1 - 1.8e-93 313.3 1.6 2.2e-93 313.1 1.6 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK52922.1 - 9.1e-10 38.1 3.2 3.1e-08 33.0 2.1 2.6 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 PIK52922.1 - 6.7e-06 25.7 0.8 9.4e-06 25.2 0.8 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 PIK52922.1 - 2e-05 23.9 0.1 3.6e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 PIK52922.1 - 4.1e-05 23.1 0.8 0.0024 17.4 0.2 3.0 2 1 1 3 3 3 1 Histidine biosynthesis protein G3P_antiterm PF04309.12 PIK52922.1 - 0.00089 18.7 1.2 1.2 8.5 0.0 3.4 3 1 0 3 3 3 2 Glycerol-3-phosphate responsive antiterminator Dus PF01207.17 PIK52922.1 - 0.0037 16.4 0.4 0.13 11.3 0.1 2.3 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) ThiG PF05690.14 PIK52922.1 - 0.021 14.1 0.5 1.9 7.8 0.1 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG PA PF02225.22 PIK52922.1 - 0.026 14.6 0.3 10 6.3 0.0 2.4 2 0 0 2 2 2 0 PA domain TMP-TENI PF02581.17 PIK52922.1 - 0.049 13.0 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 Thiamine monophosphate synthase CRM1_C PF08767.11 PIK52924.1 - 0.0016 17.7 1.5 0.0016 17.7 1.5 2.8 3 0 0 3 3 3 1 CRM1 C terminal Utp11 PF03998.13 PIK52925.1 - 2.4e-49 168.5 20.6 3e-49 168.2 20.6 1.1 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 PIK52925.1 - 0.086 12.2 2.7 0.091 12.1 0.2 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Pou PF00157.17 PIK52926.1 - 5.1e-38 128.9 0.1 1e-37 127.9 0.1 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK52926.1 - 5.9e-18 64.5 3.1 6.2e-18 64.4 0.8 2.2 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 PIK52926.1 - 0.029 14.3 0.0 0.069 13.1 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain HTH_31 PF13560.6 PIK52926.1 - 0.072 13.4 0.0 0.83 10.1 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain ABC_trans_N PF14510.6 PIK52926.1 - 0.14 12.8 0.2 1 10.0 0.0 2.3 2 0 0 2 2 2 0 ABC-transporter N-terminal Peptidase_S8 PF00082.22 PIK52927.1 - 4.4e-44 150.9 1.9 6.1e-44 150.5 1.9 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 PIK52927.1 - 1.3e-20 73.2 0.0 3.4e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8_N PF16361.5 PIK52927.1 - 0.00091 19.7 0.1 0.0021 18.6 0.1 1.6 1 0 0 1 1 1 1 N-terminal of Subtilase family S8_pro-domain PF16470.5 PIK52927.1 - 0.019 15.7 1.2 0.047 14.5 1.2 1.7 1 0 0 1 1 1 0 Peptidase S8 pro-domain CBM_14 PF01607.24 PIK52928.1 - 0.037 14.2 0.6 0.069 13.3 0.6 1.4 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DUF5320 PF17253.2 PIK52928.1 - 0.19 12.8 7.1 0.4 11.8 0.1 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5320) AAA_23 PF13476.6 PIK52928.1 - 0.91 10.0 15.6 0.12 12.8 4.1 2.4 2 0 0 2 2 2 0 AAA domain BTB PF00651.31 PIK52930.1 - 1.5e-26 92.8 5.4 6.8e-12 45.6 0.1 4.1 3 1 1 4 4 4 3 BTB/POZ domain RCC1 PF00415.18 PIK52930.1 - 1.7e-15 57.4 2.1 6.4e-07 29.9 0.6 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK52930.1 - 5.5e-07 29.2 4.7 0.00091 19.0 0.2 3.6 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat BACK PF07707.15 PIK52930.1 - 0.016 15.3 0.1 0.052 13.6 0.1 1.9 1 0 0 1 1 1 0 BTB And C-terminal Kelch XRN_M PF17846.1 PIK52930.1 - 0.27 10.1 9.5 0.025 13.6 4.5 1.7 2 0 0 2 2 2 0 Xrn1 helical domain Glyco_transf_92 PF01697.27 PIK52931.1 - 4.4e-28 98.6 0.8 6.9e-28 98.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 PIK52931.1 - 1.4e-08 35.1 0.1 3.2e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 OAD_gamma PF04277.13 PIK52931.1 - 0.078 13.6 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_S15 PF00312.22 PIK52932.1 - 6.1e-17 61.6 0.7 6.1e-17 61.6 0.7 2.4 2 0 0 2 2 2 1 Ribosomal protein S15 FGAR-AT_linker PF18072.1 PIK52932.1 - 0.21 12.2 0.7 1.1 9.9 0.2 2.2 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3504 PF12012.8 PIK52933.1 - 2.1e-51 174.1 0.4 2.7e-51 173.7 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) zf-FCS PF06467.14 PIK52934.1 - 4.4e-11 42.5 38.7 8.2e-05 22.5 0.4 5.6 5 0 0 5 5 5 4 MYM-type Zinc finger with FCS sequence motif YHS PF04945.13 PIK52934.1 - 0.0017 18.4 10.9 0.25 11.4 0.1 4.1 4 0 0 4 4 4 2 YHS domain zf-FCS PF06467.14 PIK52935.1 - 1.8e-10 40.6 38.1 1.4e-07 31.3 2.1 5.2 4 2 0 4 4 4 3 MYM-type Zinc finger with FCS sequence motif zf-MYND PF01753.18 PIK52935.1 - 3.6e-08 33.4 0.9 0.15 12.2 0.0 4.8 2 1 2 4 4 4 3 MYND finger zinc_ribbon_2 PF13240.6 PIK52935.1 - 0.02 14.6 1.9 0.02 14.6 1.9 4.9 6 0 0 6 6 6 0 zinc-ribbon domain VATC PF18716.1 PIK52935.1 - 0.048 13.5 0.9 0.048 13.5 0.9 4.8 3 2 1 4 4 4 0 Vms1-associating treble clef domain RecR PF02132.15 PIK52935.1 - 0.77 9.4 11.5 4.2 7.0 0.2 4.5 4 0 0 4 4 4 0 RecR protein DUF2116 PF09889.9 PIK52935.1 - 7.4 6.6 26.3 1.4 8.9 2.0 4.6 3 1 3 6 6 6 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) RRM_1 PF00076.22 PIK52936.1 - 7.5e-29 99.4 3.0 3.8e-16 58.7 0.6 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 PIK52936.1 - 7.7e-27 93.2 3.8 2.6e-26 91.5 3.8 2.0 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_occluded PF16842.5 PIK52936.1 - 0.039 13.8 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_3 PF08777.11 PIK52936.1 - 0.04 14.0 7.7 1.3 9.1 0.0 3.1 3 0 0 3 3 3 0 RNA binding motif RRM_7 PF16367.5 PIK52936.1 - 0.11 12.6 0.2 0.42 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif Tctex-1 PF03645.13 PIK52937.1 - 3.2e-24 85.1 0.5 5e-24 84.5 0.5 1.3 1 0 0 1 1 1 1 Tctex-1 family PBP PF01161.20 PIK52939.1 - 2.5e-17 63.4 0.1 3.2e-17 63.1 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF5111 PF17138.4 PIK52939.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5111) TFIID_20kDa PF03847.13 PIK52940.1 - 4.8e-23 81.4 3.5 1e-22 80.4 0.2 2.7 3 1 0 3 3 3 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 PIK52940.1 - 0.0038 17.6 0.1 0.0038 17.6 0.1 2.4 3 1 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK52940.1 - 0.0078 16.5 0.5 0.026 14.8 0.0 2.1 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Wbp11 PF09429.10 PIK52940.1 - 0.0094 16.3 3.3 0.0094 16.3 3.3 2.8 3 1 1 4 4 4 1 WW domain binding protein 11 Spidroin_N PF16763.5 PIK52940.1 - 0.016 15.2 1.0 0.03 14.4 0.7 1.5 1 1 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term TFIID-31kDa PF02291.15 PIK52940.1 - 0.056 13.5 0.7 1.3 9.1 0.0 2.2 1 1 1 2 2 2 0 Transcription initiation factor IID, 31kD subunit PRIMA1 PF16101.5 PIK52940.1 - 0.13 12.3 7.0 0.23 11.5 7.0 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NIF PF03031.18 PIK52941.1 - 7.4e-49 165.5 0.0 8.9e-49 165.2 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RNA_pol PF00940.19 PIK52942.1 - 3.1e-119 398.5 0.2 2.1e-108 362.9 0.0 2.0 1 1 1 2 2 2 2 DNA-dependent RNA polymerase RPOL_N PF14700.6 PIK52943.1 - 5e-39 134.6 0.0 9.5e-39 133.7 0.0 1.5 1 1 0 1 1 1 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 PIK52943.1 - 1.3e-05 25.2 0.0 4.8e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 PIK52943.1 - 0.0054 16.8 0.1 0.028 14.5 0.0 2.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR PF01535.20 PIK52943.1 - 0.032 14.5 0.1 0.17 12.2 0.0 2.4 2 0 0 2 2 2 0 PPR repeat HEAT_UF PF18817.1 PIK52943.1 - 0.033 14.4 0.5 11 6.4 0.1 2.9 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 Solute_trans_a PF03619.16 PIK52945.1 - 3.6e-20 72.6 9.9 5.7e-19 68.7 9.9 2.0 1 1 0 1 1 1 1 Organic solute transporter Ostalpha FAM176 PF14851.6 PIK52945.1 - 0.045 13.4 0.1 0.075 12.7 0.1 1.3 1 0 0 1 1 1 0 FAM176 family DUF4834 PF16118.5 PIK52945.1 - 0.064 14.2 1.5 0.45 11.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SUR7 PF06687.12 PIK52945.1 - 0.55 9.8 8.4 1.7 8.2 3.5 2.3 2 0 0 2 2 2 0 SUR7/PalI family Claudin_3 PF06653.11 PIK52945.1 - 0.64 9.9 11.0 0.31 11.0 2.8 2.3 2 0 0 2 2 2 0 Tight junction protein, Claudin-like DUF5504 PF17608.2 PIK52945.1 - 2.3 8.4 7.6 1.3 9.2 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5504) Helicase_C PF00271.31 PIK52946.1 - 1.9e-10 41.1 0.0 6.2e-10 39.4 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain MFS_1 PF07690.16 PIK52947.1 - 2.3e-15 56.4 2.5 2.7e-15 56.2 2.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK52947.1 - 0.064 12.1 11.0 0.019 13.9 5.0 2.0 1 1 1 2 2 2 0 Sugar (and other) transporter Ig_3 PF13927.6 PIK52948.1 - 0.0005 20.6 0.1 0.0028 18.2 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 PIK52948.1 - 0.013 15.8 0.2 0.04 14.2 0.2 2.0 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK52948.1 - 0.015 15.5 0.1 0.044 14.0 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK52948.1 - 0.047 14.0 0.1 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK52948.1 - 0.047 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Adeno_E3_CR1 PF02440.15 PIK52948.1 - 0.22 11.3 0.2 0.22 11.3 0.2 2.1 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 PA26 PF04636.13 PIK52949.1 - 8.2 5.2 8.9 9.2 5.1 8.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) C2-set_2 PF08205.12 PIK52950.1 - 0.0016 18.5 0.5 0.051 13.7 0.1 2.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C2-set_2 PF08205.12 PIK52951.1 - 0.00028 20.9 1.5 0.0064 16.5 0.1 2.9 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK52953.1 - 8.1e-05 23.1 0.3 0.0072 16.9 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain ODV-E18 PF10717.9 PIK52953.1 - 0.0071 16.2 0.8 0.018 14.9 0.8 1.7 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 C2-set_2 PF08205.12 PIK52953.1 - 0.021 14.9 0.6 0.37 10.9 0.1 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 PIK52953.1 - 0.031 14.5 0.2 0.44 10.8 0.0 2.9 4 0 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK52953.1 - 0.077 13.1 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 PIK52953.1 - 0.095 12.9 0.4 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin V-set domain V-set_2 PF15910.5 PIK52953.1 - 3 8.0 8.1 1 9.5 1.2 2.7 3 0 0 3 3 3 0 ICOS V-set domain Pkinase_Tyr PF07714.17 PIK52954.1 - 3.8e-23 82.1 0.0 9.8e-23 80.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK52954.1 - 3.5e-15 56.1 0.0 5.8e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 PIK52955.1 - 1.3e-05 25.6 0.0 4e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK52955.1 - 0.00013 22.0 0.1 0.00027 21.0 0.0 1.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) U62_UL91 PF17442.2 PIK52955.1 - 0.11 12.5 0.1 0.31 11.0 0.1 1.8 2 0 0 2 2 2 0 Functional domain of U62 and UL91 proteins Elong_Iki1 PF10483.9 PIK52957.1 - 4.8e-09 36.1 0.1 5.2e-09 36.0 0.1 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 zf-MYND PF01753.18 PIK52958.1 - 2.1e-05 24.5 7.9 2.1e-05 24.5 7.9 3.3 3 1 0 3 3 3 1 MYND finger TPR_2 PF07719.17 PIK52958.1 - 2.4e-05 24.1 0.9 0.078 13.1 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK52958.1 - 9e-05 22.1 1.3 0.00074 19.2 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK52958.1 - 0.015 15.6 1.1 0.71 10.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Repressor_Mnt PF11423.8 PIK52958.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 Regulatory protein Mnt Glyco_transf_29 PF00777.18 PIK52958.1 - 0.61 9.4 4.7 0.16 11.4 1.3 1.8 2 1 0 2 2 2 0 Glycosyltransferase family 29 (sialyltransferase) Neuralized PF07177.12 PIK52959.1 - 6.9e-191 626.6 2.3 2.7e-41 141.0 0.0 6.1 6 0 0 6 6 6 6 Neuralized wnt PF00110.19 PIK52961.1 - 5.3e-124 413.8 22.0 6.1e-124 413.6 22.0 1.0 1 0 0 1 1 1 1 wnt family Imm-NTF2-2 PF15631.6 PIK52962.1 - 0.057 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Pro_isomerase PF00160.21 PIK52964.1 - 1.1e-21 77.7 0.0 1.2e-21 77.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CAP PF00188.26 PIK52965.1 - 3.7e-10 40.7 0.6 4.8e-10 40.4 0.6 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Sulfatase_C PF14707.6 PIK52966.1 - 8.7e-27 94.3 0.0 1.5e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK52966.1 - 2.5e-24 86.2 0.1 3e-23 82.7 0.0 2.3 2 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 PIK52966.1 - 0.083 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Ldl_recept_a PF00057.18 PIK52967.1 - 8.7e-57 189.1 93.5 1.7e-12 47.4 6.8 6.2 6 1 0 6 6 6 5 Low-density lipoprotein receptor domain class A SRCR PF00530.18 PIK52967.1 - 8.1e-19 68.0 0.3 8.1e-19 68.0 0.3 2.7 2 1 1 3 3 3 1 Scavenger receptor cysteine-rich domain CorC_HlyC PF03471.17 PIK52967.1 - 0.084 12.9 0.0 20 5.3 0.0 3.3 4 0 0 4 4 4 0 Transporter associated domain SRCR PF00530.18 PIK52968.1 - 7e-06 26.5 0.0 7.9e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK52969.1 - 3.5e-209 678.9 49.0 1.2e-31 109.2 2.7 7.0 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK52969.1 - 5.4e-44 148.7 17.6 3e-06 27.7 0.1 7.6 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK52969.1 - 2e-26 92.7 6.4 0.007 16.9 0.1 7.7 7 0 0 7 7 7 7 Hepsin, SRCR domain DUF2997 PF11211.8 PIK52969.1 - 0.0004 20.1 0.6 20 5.1 0.1 5.2 5 0 0 5 5 5 1 Protein of unknown function (DUF2997) SapB_2 PF03489.17 PIK52969.1 - 0.0026 17.8 0.1 2.8e+02 1.7 0.0 6.6 7 0 0 7 7 7 0 Saposin-like type B, region 2 Bac_chlorC PF02043.17 PIK52969.1 - 0.0077 16.2 10.3 20 5.3 0.0 6.0 6 0 0 6 6 6 1 Bacteriochlorophyll C binding protein DUF3195 PF11424.8 PIK52969.1 - 0.099 12.7 6.3 1.1e+02 2.9 0.0 6.1 6 0 0 6 6 6 0 Protein of unknown function (DUF3195) NB PF04159.13 PIK52969.1 - 0.34 11.0 5.7 0.39 10.8 0.3 3.1 3 0 0 3 3 3 0 NB glycoprotein AIP3 PF03915.13 PIK52970.1 - 3.1 6.8 4.4 6.7 5.7 4.4 1.6 1 1 0 1 1 1 0 Actin interacting protein 3 Fz PF01392.22 PIK52971.1 - 4.6e-05 24.0 25.6 0.0007 20.2 2.9 3.9 4 1 0 4 4 4 2 Fz domain DUF753 PF05444.12 PIK52972.1 - 3.6e-05 23.8 23.8 0.012 15.7 2.5 4.2 4 0 0 4 4 4 3 Protein of unknown function (DUF753) QVR PF17064.5 PIK52972.1 - 0.072 13.3 0.1 0.072 13.3 0.1 5.8 6 0 0 6 6 6 0 Sleepless protein IBV_3B PF03622.13 PIK52972.1 - 2.3 8.4 7.7 72 3.6 0.1 4.2 4 0 0 4 4 4 0 IBV 3B protein Rad50_zn_hook PF04423.14 PIK52972.1 - 4.8 7.1 10.9 14 5.6 0.4 3.6 4 0 0 4 4 4 0 Rad50 zinc hook motif HYR PF02494.16 PIK52973.1 - 3.1e-08 33.8 0.1 7.5e-08 32.6 0.0 1.6 2 0 0 2 2 2 1 HYR domain Fz PF01392.22 PIK52973.1 - 0.0031 18.1 3.3 0.0032 18.1 1.9 1.8 2 0 0 2 2 2 1 Fz domain HYR PF02494.16 PIK52974.1 - 1.4e-47 159.9 13.6 2.1e-20 72.8 0.2 4.7 4 1 0 4 4 4 4 HYR domain EGF PF00008.27 PIK52974.1 - 0.25 11.7 2.4 0.58 10.5 2.4 1.6 1 0 0 1 1 1 0 EGF-like domain HYR PF02494.16 PIK52975.1 - 2.6e-43 146.2 6.7 4.1e-14 52.7 0.1 3.5 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK52975.1 - 0.015 15.5 0.0 30 4.8 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) fn3 PF00041.21 PIK52976.1 - 5.4e-12 45.9 1.3 3.1e-05 24.2 0.0 2.8 2 1 0 2 2 2 2 Fibronectin type III domain IL6Ra-bind PF09240.10 PIK52976.1 - 0.013 16.0 0.8 0.035 14.5 0.8 1.7 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding U3_snoRNA_assoc PF08297.11 PIK52977.1 - 0.075 13.7 0.2 0.075 13.7 0.2 1.9 2 0 0 2 2 2 0 U3 snoRNA associated Axin_b-cat_bind PF08833.10 PIK52978.1 - 0.15 12.2 1.9 6.5 6.9 0.0 2.7 3 0 0 3 3 3 0 Axin beta-catenin binding domain Duffy_binding PF05424.11 PIK52978.1 - 0.16 12.0 4.0 0.39 10.8 4.0 1.7 1 1 0 1 1 1 0 Duffy binding domain OrsD PF12013.8 PIK52978.1 - 1.6 9.2 6.7 0.94 10.0 1.3 2.4 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D AXH PF08517.12 PIK52979.1 - 0.015 15.9 0.0 0.026 15.1 0.0 1.4 1 0 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) Phage_integrase PF00589.22 PIK52980.1 - 0.027 14.2 0.2 0.051 13.4 0.2 1.4 1 0 0 1 1 1 0 Phage integrase family CDC45 PF02724.14 PIK52980.1 - 0.34 9.2 12.8 1.1 7.4 5.1 2.2 2 0 0 2 2 2 0 CDC45-like protein SDA1 PF05285.12 PIK52980.1 - 1.9 7.8 19.6 3.7 6.9 19.6 1.4 1 0 0 1 1 1 0 SDA1 eIF-3c_N PF05470.12 PIK52980.1 - 9.5 4.4 8.1 14 3.8 8.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus zf-B_box PF00643.24 PIK52981.1 - 1e-11 44.8 22.2 4.6e-10 39.5 7.2 3.9 4 0 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK52981.1 - 4.5e-09 36.2 7.2 4.5e-09 36.2 7.2 3.3 3 1 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK52981.1 - 3.7e-08 33.1 5.8 3.7e-08 33.1 5.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK52981.1 - 5.9e-08 32.5 8.0 5.9e-08 32.5 8.0 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK52981.1 - 6e-08 32.4 8.7 6e-08 32.4 8.7 3.4 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK52981.1 - 1.6e-06 28.0 8.1 1.6e-06 28.0 8.1 3.6 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK52981.1 - 2.4e-06 27.6 9.0 2.4e-06 27.6 9.0 3.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK52981.1 - 3.9e-06 27.1 7.5 3.9e-06 27.1 7.5 3.5 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 PIK52981.1 - 0.00038 20.2 7.2 0.00038 20.2 7.2 3.4 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 Apolipoprotein PF01442.18 PIK52981.1 - 0.0074 16.2 1.4 0.011 15.6 1.4 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Cache_3-Cache_2 PF17201.4 PIK52981.1 - 0.021 14.1 1.7 0.034 13.4 1.7 1.3 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain DUF4164 PF13747.6 PIK52981.1 - 0.16 12.2 4.1 1.1 9.6 3.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) zf-H2C2_2 PF13465.6 PIK52981.1 - 8.3 7.0 14.3 17 6.1 0.4 4.9 5 0 0 5 5 5 0 Zinc-finger double domain DUF3377 PF11857.8 PIK52982.1 - 0.013 15.4 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Asp5 PF17000.5 PIK52982.1 - 0.46 10.6 4.0 9.5 6.4 3.0 2.2 1 1 1 2 2 2 0 Accessory secretory protein Sec, Asp5 Aldedh PF00171.22 PIK52985.1 - 4.4e-41 140.9 0.0 4.9e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 PIK52985.1 - 0.052 13.0 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) zf-Di19 PF05605.12 PIK52986.1 - 0.28 11.5 1.1 6.3 7.2 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF4602 PF15375.6 PIK52987.1 - 0.022 15.1 1.0 1.2 9.5 1.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4602) UPF0449 PF15136.6 PIK52988.1 - 0.019 15.4 1.4 0.04 14.4 0.5 1.9 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Aldedh PF00171.22 PIK52989.1 - 1.4e-153 511.7 0.0 1.7e-153 511.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 PIK52989.1 - 0.0046 16.4 0.1 0.62 9.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) VGLL4 PF15245.6 PIK52990.1 - 1.9e-05 24.9 2.6 2.2e-05 24.7 0.1 2.0 2 0 0 2 2 2 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.14 PIK52990.1 - 5.1e-05 22.9 0.3 0.42 10.4 0.1 2.4 2 0 0 2 2 2 2 Vestigial/Tondu family AdoMet_Synthase PF01941.19 PIK52990.1 - 0.083 11.7 0.1 0.52 9.1 0.1 1.8 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) ATG7_N PF16420.5 PIK52991.1 - 3.1e-81 273.3 0.0 4.4e-81 272.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 PIK52991.1 - 1.1e-20 74.0 0.0 5.2e-20 71.8 0.0 1.9 1 1 1 2 2 2 1 ThiF family NEMO PF11577.8 PIK52992.1 - 0.02 14.9 0.4 0.048 13.7 0.4 1.7 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO 7TM_transglut PF14402.6 PIK52992.1 - 0.022 14.2 1.0 0.043 13.3 1.0 1.4 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase Phospholip_A2_2 PF05826.12 PIK52992.1 - 0.05 13.8 2.3 0.14 12.4 2.3 1.8 1 0 0 1 1 1 0 Phospholipase A2 MAT1 PF06391.13 PIK52992.1 - 0.24 11.2 4.8 0.45 10.3 4.8 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 NRBF2_MIT PF17169.4 PIK52992.1 - 0.36 11.1 2.6 5 7.4 0.8 2.4 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 ARPC4 PF05856.12 PIK52993.1 - 2.5e-81 271.2 10.0 2.8e-81 271.0 10.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.5 PIK52993.1 - 0.0049 17.0 0.2 0.0081 16.3 0.2 1.4 1 0 0 1 1 1 1 Sm_like domain Ephrin_rec_like PF07699.13 PIK52994.1 - 7e-08 32.1 63.8 7.9e-06 25.5 4.3 7.8 4 3 3 7 7 7 6 Putative ephrin-receptor like NCD3G PF07562.14 PIK52994.1 - 0.0011 18.9 56.5 0.043 13.8 2.5 8.1 5 3 2 8 8 8 4 Nine Cysteines Domain of family 3 GPCR PHD PF00628.29 PIK52995.1 - 2.7e-08 33.5 12.4 6.2e-08 32.4 12.4 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK52995.1 - 0.021 14.4 6.8 0.043 13.4 6.8 1.5 1 0 0 1 1 1 0 PHD-finger zf-CW PF07496.15 PIK52995.1 - 0.088 12.8 3.9 0.23 11.5 3.9 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger Pkinase PF00069.25 PIK52996.1 - 5.3e-63 212.8 0.0 6.5e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK52996.1 - 8.7e-40 136.6 0.0 1.1e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 PIK52996.1 - 3.8e-11 43.5 2.1 8e-11 42.5 2.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 PIK52996.1 - 0.0085 15.4 0.0 0.018 14.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK52996.1 - 0.0095 14.9 0.1 0.014 14.3 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK52996.1 - 0.027 14.4 0.3 0.064 13.2 0.3 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF5529 PF17669.1 PIK52996.1 - 0.052 13.6 0.2 0.29 11.2 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5529) Pkinase_fungal PF17667.1 PIK52996.1 - 0.11 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase C1_1 PF00130.22 PIK52997.1 - 1.4e-23 82.5 17.7 3e-16 59.0 8.4 2.2 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK52997.1 - 2.6e-07 30.9 9.6 0.00045 20.5 4.4 2.4 2 0 0 2 2 2 2 C1 domain PHD_2 PF13831.6 PIK52997.1 - 0.00046 19.7 1.6 0.00046 19.7 1.6 3.2 3 0 0 3 3 3 2 PHD-finger zf-RING-like PF08746.11 PIK52997.1 - 0.0019 18.5 15.4 0.033 14.5 2.6 2.6 2 1 0 2 2 2 2 RING-like domain PHD_4 PF16866.5 PIK52997.1 - 0.0078 16.3 5.0 0.89 9.7 0.7 2.6 2 0 0 2 2 2 2 PHD-finger FYVE_2 PF02318.16 PIK52997.1 - 0.01 16.1 7.7 0.051 13.8 2.5 2.3 2 1 0 2 2 2 0 FYVE-type zinc finger Zf_RING PF16744.5 PIK52997.1 - 0.033 14.3 7.1 1.5 9.0 1.6 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING_9 PF13901.6 PIK52997.1 - 0.077 13.0 12.6 0.49 10.4 1.4 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 PIK52997.1 - 0.14 12.1 17.6 0.24 11.3 1.7 2.7 2 1 0 2 2 2 0 PHD-finger DZR PF12773.7 PIK52997.1 - 0.46 10.5 9.8 0.41 10.7 3.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-ACC PF17848.1 PIK52997.1 - 0.97 9.6 0.1 0.97 9.6 0.1 3.6 3 1 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-RRN7 PF11781.8 PIK52997.1 - 8.1 6.2 10.3 1.4 8.7 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 C2 PF00168.30 PIK52998.1 - 3.9e-05 23.9 0.1 4.4e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 C2 domain TIMP PF00965.17 PIK52999.1 - 6.5e-19 68.4 5.5 1.6e-17 63.9 5.5 2.5 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase BppL_N PF18338.1 PIK52999.1 - 0.19 11.6 1.1 0.39 10.5 1.1 1.5 1 0 0 1 1 1 0 Lower baseplate protein N-terminal domain PALP PF00291.25 PIK53000.1 - 5.5e-08 32.6 0.0 1.1e-07 31.6 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4265 PF14085.6 PIK53000.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) SKI PF01202.22 PIK53001.1 - 1.3e-27 96.9 0.0 1.6e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase Thr_synth_N PF14821.6 PIK53001.1 - 2e-08 34.3 0.0 3.8e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Threonine synthase N terminus AAA_18 PF13238.6 PIK53001.1 - 6.1e-06 26.8 0.0 1e-05 26.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 PIK53001.1 - 0.0096 15.8 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA PF00004.29 PIK53001.1 - 0.026 15.0 0.0 0.039 14.4 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 PIK53001.1 - 0.055 13.7 0.1 0.13 12.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 PIK53001.1 - 0.069 13.1 0.1 0.18 11.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Oxidored_nitro PF00148.19 PIK53001.1 - 0.086 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase AAA_17 PF13207.6 PIK53001.1 - 0.12 12.8 0.1 5.2 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4598 PF15370.6 PIK53002.1 - 1e-14 54.9 5.7 1e-14 54.9 5.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4598) MgtE PF01769.16 PIK53003.1 - 1.3e-51 174.1 21.5 3e-26 92.2 3.7 2.7 3 0 0 3 3 3 2 Divalent cation transporter HNF-1B_C PF04812.13 PIK53003.1 - 0.2 11.4 2.1 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus UDG PF03167.19 PIK53004.1 - 9.3e-19 67.9 0.0 1.4e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Bromodomain PF00439.25 PIK53005.1 - 1.2e-85 281.7 18.0 2e-21 75.8 0.8 5.6 5 0 0 5 5 5 5 Bromodomain BAH PF01426.18 PIK53005.1 - 1.6e-39 134.5 8.1 4.8e-24 84.5 0.6 2.9 3 0 0 3 3 3 2 BAH domain HMG_box PF00505.19 PIK53005.1 - 1.2e-11 44.9 0.0 3.6e-11 43.3 0.0 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK53005.1 - 2.4e-09 37.6 0.1 7.9e-09 36.0 0.1 1.9 1 0 0 1 1 1 1 HMG-box domain SpoIIIAH PF12685.7 PIK53005.1 - 1.1 9.0 15.5 0.33 10.8 5.3 3.4 3 0 0 3 3 3 0 SpoIIIAH-like protein Cytomega_UL84 PF06284.11 PIK53005.1 - 3.9 5.8 7.7 6.2 5.2 7.7 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Lectin_C PF00059.21 PIK53006.1 - 4.2e-13 50.0 0.9 1.2e-12 48.5 0.0 1.9 2 0 0 2 2 2 1 Lectin C-type domain Lectin_C PF00059.21 PIK53007.1 - 1e-27 97.0 11.7 1.8e-13 51.1 0.2 2.8 3 0 0 3 3 3 2 Lectin C-type domain Chordopox_A33R PF05966.12 PIK53007.1 - 0.00033 20.0 0.1 0.017 14.4 0.0 2.2 2 0 0 2 2 2 2 Chordopoxvirus A33R protein COPI_C PF06957.11 PIK53010.1 - 6.7e-182 604.7 0.0 8.8e-182 604.3 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 PIK53010.1 - 3.1e-136 455.0 0.0 5.3e-136 454.2 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 PIK53010.1 - 2.3e-38 129.5 20.9 2.9e-07 31.1 0.6 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53010.1 - 7.2e-10 39.0 1.2 7.8e-06 26.1 0.0 5.2 3 2 4 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK53010.1 - 0.045 12.4 6.6 1.2 7.6 0.1 3.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 PRANC PF09372.10 PIK53011.1 - 0.061 13.7 0.1 0.16 12.3 0.1 1.7 1 0 0 1 1 1 0 PRANC domain GpcrRhopsn4 PF10192.9 PIK53012.1 - 4.4e-16 59.1 7.2 6.7e-14 51.9 1.8 2.7 3 0 0 3 3 3 2 Rhodopsin-like GPCR transmembrane domain TCR_zetazeta PF11628.8 PIK53012.1 - 1.6 8.5 5.2 3.2 7.5 1.7 2.5 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain MORN PF02493.20 PIK53013.1 - 4.1e-40 133.3 46.9 4.4e-10 38.9 2.1 7.5 7 0 0 7 7 7 7 MORN repeat DUF1579 PF07617.11 PIK53013.1 - 0.16 11.9 4.1 1.8 8.4 0.5 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1579) Rax2 PF12768.7 PIK53014.1 - 0.00077 19.0 0.1 0.00078 19.0 0.1 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Shisa PF13908.6 PIK53014.1 - 0.0071 16.6 0.0 0.0071 16.6 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF4577 PF15145.6 PIK53014.1 - 0.0098 15.9 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) TMEM154 PF15102.6 PIK53014.1 - 0.034 14.1 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family LapA_dom PF06305.11 PIK53014.1 - 0.035 13.9 0.3 0.047 13.5 0.3 1.1 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Protocadherin PF08374.11 PIK53014.1 - 0.059 13.3 0.1 0.064 13.2 0.1 1.1 1 0 0 1 1 1 0 Protocadherin PRIMA1 PF16101.5 PIK53014.1 - 0.065 13.3 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 PIK53014.1 - 0.18 12.7 0.9 0.33 11.9 0.9 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.5 PIK53014.1 - 0.92 9.4 5.9 1.4 8.8 5.9 1.5 1 1 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF1180 PF06679.12 PIK53014.1 - 0.93 9.9 2.2 1.1 9.7 2.2 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) FeoB_associated PF12669.7 PIK53014.1 - 9.3 6.7 14.0 0.14 12.6 2.7 2.2 1 1 1 2 2 2 0 FeoB-associated Cys-rich membrane protein MSG PF02349.15 PIK53015.1 - 0.014 15.6 0.1 22 5.3 0.1 3.2 1 1 2 3 3 3 0 Major surface glycoprotein rve PF00665.26 PIK53016.1 - 5.4e-21 75.0 0.0 1e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53016.1 - 5.5e-17 61.6 0.7 9.7e-17 60.8 0.7 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK53016.1 - 1.4e-07 31.6 0.5 2.6e-07 30.7 0.5 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK53016.1 - 0.0007 19.3 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK53017.1 - 1.4e-35 121.3 0.2 3.9e-35 119.9 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53017.1 - 8.3e-33 112.8 0.0 2.1e-32 111.5 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK53017.1 - 1.1e-18 67.6 0.3 1.9e-18 66.8 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK53018.1 - 3.1e-09 36.7 0.0 4.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK53019.1 - 3.3e-26 91.2 0.0 5.8e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53019.1 - 6.8e-15 55.2 0.0 1.3e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK53019.1 - 0.00059 19.4 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK53020.1 - 3.8e-20 72.2 0.0 5e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK53020.1 - 0.00091 19.0 0.0 0.0027 17.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Exo_endo_phos PF03372.23 PIK53021.1 - 0.0031 17.1 0.0 0.0047 16.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-RVT PF13966.6 PIK53022.1 - 1.3e-07 32.2 3.0 5.6e-06 27.0 0.8 2.4 2 0 0 2 2 2 2 zinc-binding in reverse transcriptase rve PF00665.26 PIK53023.1 - 7e-17 61.7 0.0 1e-16 61.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53023.1 - 5.3e-15 55.3 0.3 9.7e-15 54.4 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK53023.1 - 0.0011 18.7 0.0 0.0025 17.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Put_Phosphatase PF06888.12 PIK53023.1 - 0.018 14.4 0.0 0.094 12.1 0.0 1.9 1 1 1 2 2 2 0 Putative Phosphatase EPTP PF03736.17 PIK53023.1 - 0.093 12.7 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 EPTP domain RVT_1 PF00078.27 PIK53024.1 - 0.00057 19.5 0.0 0.0057 16.2 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK53024.1 - 0.0098 15.4 0.1 0.014 14.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family rve PF00665.26 PIK53025.1 - 0.00021 21.4 0.0 0.00036 20.7 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain KfrA_N PF11740.8 PIK53027.1 - 0.058 14.1 0.3 4.1 8.1 0.2 2.8 2 1 0 3 3 3 0 Plasmid replication region DNA-binding N-term Poxvirus_B22R_N PF13169.6 PIK53027.1 - 0.089 13.3 0.2 0.15 12.6 0.2 1.4 1 0 0 1 1 1 0 Poxvirus B22R protein N-terminal zf-Di19 PF05605.12 PIK53028.1 - 1 9.7 5.9 13 6.2 0.3 3.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding E7 PF00527.18 PIK53028.1 - 2.7 8.2 5.9 1.8 8.8 1.7 2.9 2 0 0 2 2 2 0 E7 protein, Early protein DEC-1_N PF04625.13 PIK53029.1 - 0.055 12.5 0.2 0.067 12.2 0.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region zf-CCHC PF00098.23 PIK53029.1 - 0.12 12.4 0.8 0.28 11.3 0.8 1.6 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 PIK53030.1 - 1.9e-07 30.9 0.0 0.0098 15.4 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) PNMA PF14893.6 PIK53031.1 - 5.2e-11 42.5 1.4 1e-10 41.5 1.4 1.4 1 0 0 1 1 1 1 PNMA KASH_CCD PF14662.6 PIK53031.1 - 0.006 16.4 1.6 0.013 15.3 1.6 1.5 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DDE_Tnp_ISL3 PF01610.17 PIK53031.1 - 0.016 14.9 2.7 0.02 14.6 0.0 2.5 3 1 0 3 3 3 0 Transposase Blo-t-5 PF11642.8 PIK53031.1 - 0.072 13.1 2.2 0.13 12.3 0.2 2.2 2 0 0 2 2 2 0 Mite allergen Blo t 5 DUF2524 PF10732.9 PIK53031.1 - 0.09 13.1 1.5 0.93 9.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) DDE_Tnp_1_7 PF13843.6 PIK53032.1 - 7.1e-37 127.5 0.0 8.6e-37 127.2 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.21 PIK53032.1 - 0.026 14.2 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain DDE_Tnp_1_7 PF13843.6 PIK53033.1 - 4.5e-15 55.8 0.0 6.3e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 Tyr_Deacylase PF02580.16 PIK53033.1 - 0.19 12.2 0.0 0.41 11.2 0.0 1.5 2 0 0 2 2 2 0 D-Tyr-tRNA(Tyr) deacylase UPF0552 PF10574.9 PIK53034.1 - 0.055 12.8 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Arp2/3-interacting proteins Arpin RVT_1 PF00078.27 PIK53035.1 - 2.3e-25 89.4 0.0 3e-25 89.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_21 PF02992.14 PIK53036.1 - 6.9e-07 28.7 0.0 9.6e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Transposase family tnp2 RVT_1 PF00078.27 PIK53037.1 - 3.4e-44 151.0 0.2 4e-44 150.8 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK53038.1 - 1.4e-18 67.2 0.0 2.7e-18 66.3 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) p450 PF00067.22 PIK53039.1 - 9.6e-82 275.2 0.0 1.1e-81 274.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 PIK53040.1 - 5.2e-46 156.6 0.1 6.9e-46 156.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53040.1 - 1.3e-32 113.2 0.0 1.8e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK53040.1 - 9.8e-13 48.4 0.1 1.3e-12 48.0 0.1 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK53041.1 - 2.4e-24 85.9 0.4 2.7e-24 85.7 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53041.1 - 3.1e-18 66.2 0.2 4.3e-18 65.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK53041.1 - 1.4e-06 28.4 0.2 1.7e-06 28.1 0.2 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK53042.1 - 4.5e-07 29.5 0.0 6.1e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53042.1 - 0.037 13.6 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Calx-beta PF03160.14 PIK53043.1 - 1.3e-19 70.2 4.8 3.4e-11 43.2 1.2 2.6 3 0 0 3 3 3 2 Calx-beta domain HYR PF02494.16 PIK53043.1 - 0.00015 22.0 0.2 0.00044 20.5 0.2 1.8 1 0 0 1 1 1 1 HYR domain DUF4843 PF16132.5 PIK53043.1 - 0.078 12.5 0.0 3.2 7.3 0.0 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4843) 7tm_2 PF00002.24 PIK53045.1 - 2.4e-14 53.2 5.9 3.6e-14 52.7 5.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK53045.1 - 2.6e-14 53.5 3.7 5.5e-14 52.4 3.7 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif CDC37_M PF08565.11 PIK53045.1 - 0.011 15.6 2.7 1.8 8.5 0.0 3.2 2 1 1 3 3 3 0 Cdc37 Hsp90 binding domain Band_7_C PF16200.5 PIK53045.1 - 0.11 12.5 1.2 0.76 9.9 0.2 2.6 3 0 0 3 3 3 0 C-terminal region of band_7 EMP70 PF02990.16 PIK53045.1 - 6 5.4 10.3 8.8 4.9 10.3 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 Neurexophilin PF06312.12 PIK53047.1 - 0.016 14.7 0.1 0.029 13.8 0.1 1.5 1 0 0 1 1 1 0 Neurexophilin Miff PF05644.11 PIK53048.1 - 5.9e-18 65.5 0.6 1.1e-12 48.2 0.0 2.0 1 1 1 2 2 2 2 Mitochondrial and peroxisomal fission factor Mff DUF1690 PF07956.11 PIK53048.1 - 0.089 13.2 0.9 0.12 12.8 0.9 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Tmemb_185A PF10269.9 PIK53049.1 - 1.6e-11 44.4 9.7 2.9e-11 43.5 9.7 1.5 1 1 0 1 1 1 1 Transmembrane Fragile-X-F protein ABC2_membrane_5 PF13346.6 PIK53049.1 - 0.042 13.4 0.6 0.042 13.4 0.6 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein LysE PF01810.18 PIK53049.1 - 0.36 10.3 7.7 0.13 11.7 4.5 1.7 2 0 0 2 2 2 0 LysE type translocator FMN_red PF03358.15 PIK53050.1 - 8.2e-22 77.6 0.0 1.3e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 PIK53050.1 - 0.0045 16.7 0.0 0.0076 16.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold DDE_Tnp_4 PF13359.6 PIK53051.1 - 2.2e-07 30.7 0.0 4.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Viral_helicase1 PF01443.18 PIK53051.1 - 0.036 13.8 0.2 0.77 9.5 0.0 2.5 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Frizzled PF01534.17 PIK53052.1 - 9.5e-14 51.2 1.0 1.2e-13 50.8 1.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region MTS PF05175.14 PIK53053.1 - 4.5e-12 45.9 0.0 1.7e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 PIK53053.1 - 4.8e-06 27.2 0.0 5.3e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 PIK53053.1 - 2.9e-05 23.6 0.1 0.0014 18.0 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK53053.1 - 0.00017 21.4 0.0 0.00024 20.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK53053.1 - 0.00026 20.9 0.0 0.0025 17.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK53053.1 - 0.00047 20.7 0.0 0.047 14.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 PIK53053.1 - 0.0072 15.8 0.0 0.84 9.1 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 PIK53053.1 - 0.0097 16.6 0.0 0.15 12.8 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_24 PF13578.6 PIK53053.1 - 0.023 15.7 0.0 0.08 14.0 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain DUF2020 PF09449.10 PIK53053.1 - 0.032 14.1 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2020) adh_short PF00106.25 PIK53053.1 - 0.18 11.2 0.2 0.42 10.0 0.2 1.6 1 1 0 1 1 1 0 short chain dehydrogenase Ig_3 PF13927.6 PIK53054.1 - 7.5e-06 26.5 2.8 0.019 15.6 0.2 3.1 2 2 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK53054.1 - 1e-05 25.7 0.3 0.0018 18.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK53054.1 - 5.5e-05 23.1 0.1 0.0019 18.2 0.0 2.6 1 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK53054.1 - 0.0046 17.1 0.3 2.7 8.2 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK53055.1 - 5.5e-26 91.4 0.0 7.2e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK53055.1 - 2.6e-10 40.1 0.0 5e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain KN17_SH3 PF18131.1 PIK53055.1 - 0.0065 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain DUF4834 PF16118.5 PIK53055.1 - 0.047 14.6 0.7 0.085 13.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 PIK53055.1 - 0.047 14.6 0.0 0.1 13.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 PIK53055.1 - 1.2 8.9 12.2 1 9.2 10.8 1.5 1 1 0 1 1 1 0 Rifin RVT_1 PF00078.27 PIK53056.1 - 8.5e-08 32.0 0.2 1.8e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 PIK53056.1 - 0.12 12.8 0.1 0.38 11.1 0.1 1.8 1 0 0 1 1 1 0 PRANC domain zf-C3HC4_3 PF13920.6 PIK53057.1 - 1.1e-31 108.4 42.4 1.2e-10 41.0 10.2 3.3 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) Ank_4 PF13637.6 PIK53057.1 - 1e-18 67.4 2.4 4.5e-09 36.7 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK53057.1 - 8.7e-18 63.9 1.4 7.2e-08 32.5 0.4 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 PIK53057.1 - 2.9e-16 59.8 0.2 4.2e-08 33.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK53057.1 - 1.6e-13 50.6 0.4 4.4e-07 30.1 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK53057.1 - 3.3e-13 48.5 0.2 2.8e-05 24.2 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat zf-C3HC4_2 PF13923.6 PIK53057.1 - 1.9e-08 34.0 10.1 1.9e-08 34.0 10.1 3.8 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK53057.1 - 4.6e-08 32.8 42.0 0.0033 17.3 7.9 4.5 3 1 1 4 4 4 3 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK53057.1 - 0.0018 18.5 46.7 0.0093 16.3 9.7 3.8 3 1 0 3 3 3 3 Ring finger domain zf-RING_5 PF14634.6 PIK53057.1 - 0.03 14.3 46.8 0.037 14.0 9.4 4.2 3 2 1 4 4 4 0 zinc-RING finger domain Nrf1_DNA-bind PF10491.9 PIK53057.1 - 0.087 12.5 1.5 0.11 12.2 0.1 1.8 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Vps39_2 PF10367.9 PIK53057.1 - 0.1 13.1 0.3 0.1 13.1 0.3 4.1 3 2 2 5 5 3 0 Vacuolar sorting protein 39 domain 2 zf-RING_11 PF17123.5 PIK53057.1 - 2.2 8.1 17.8 14 5.5 0.6 5.2 4 1 0 4 4 4 0 RING-like zinc finger Fibrinogen_C PF00147.18 PIK53058.1 - 2.1e-70 237.0 10.4 8.4e-40 136.9 3.8 2.4 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53058.1 - 4.7e-06 26.5 7.4 4.7e-06 26.5 7.4 2.6 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK53058.1 - 9.4e-05 22.5 10.9 9.4e-05 22.5 10.9 2.9 1 1 1 2 2 2 1 EGF domain VWC PF00093.18 PIK53058.1 - 0.0032 17.7 6.8 0.0032 17.7 6.8 2.6 2 0 0 2 2 2 1 von Willebrand factor type C domain EGF PF00008.27 PIK53058.1 - 0.0036 17.6 7.7 0.0036 17.6 7.7 2.1 2 0 0 2 2 2 1 EGF-like domain I-set PF07679.16 PIK53059.1 - 0.0018 18.3 0.0 0.011 15.8 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 PIK53059.1 - 0.0022 18.2 0.0 0.0053 16.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK53059.1 - 0.0022 18.6 0.0 0.018 15.7 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK53059.1 - 0.13 12.6 0.0 3.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain DUF5641 PF18701.1 PIK53060.1 - 3.5e-23 81.6 1.1 3.5e-23 81.6 1.1 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5641) Peptidase_A17 PF05380.13 PIK53060.1 - 3.6e-16 59.6 0.0 8.1e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK53060.1 - 7.1e-14 52.0 0.0 1.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53060.1 - 1.1e-06 28.7 2.0 2.5e-06 27.5 2.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK53060.1 - 0.0022 17.7 0.0 0.024 14.4 0.0 2.8 4 0 0 4 4 4 1 Integrase core domain zf-H2C2 PF09337.10 PIK53060.1 - 0.076 13.3 2.9 0.18 12.1 2.9 1.7 1 0 0 1 1 1 0 H2C2 zinc finger Fibrinogen_C PF00147.18 PIK53061.1 - 5.8e-89 297.7 5.1 1.9e-30 106.3 0.2 3.3 3 0 0 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53061.1 - 5.3e-13 48.7 25.0 1.2e-07 31.6 8.5 4.2 5 0 0 5 5 4 2 TILa domain EGF_3 PF12947.7 PIK53061.1 - 2.1e-05 24.6 31.8 0.00058 20.0 12.2 7.0 5 2 2 7 7 7 2 EGF domain fn3_2 PF16893.5 PIK53061.1 - 0.00024 21.2 0.7 9.3 6.5 0.0 3.3 3 0 0 3 3 3 2 Fibronectin type III domain Sec-ASP3 PF15432.6 PIK53061.1 - 0.00087 19.4 0.1 15 5.8 0.0 3.2 3 0 0 3 3 3 1 Accessory Sec secretory system ASP3 VWC PF00093.18 PIK53061.1 - 0.0041 17.4 25.4 0.012 16.0 8.7 4.4 4 0 0 4 4 2 2 von Willebrand factor type C domain DUF4251 PF14059.6 PIK53061.1 - 0.0051 16.8 1.9 17 5.4 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4251) ATP-gua_Ptrans PF00217.19 PIK53061.1 - 0.0056 16.2 0.1 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, C-terminal catalytic domain DUF1735 PF08522.10 PIK53061.1 - 0.013 16.1 2.6 8.3 7.0 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1735) Biotin_carb_C PF02785.19 PIK53061.1 - 0.034 14.3 0.0 7.6 6.7 0.0 3.1 3 0 0 3 3 3 0 Biotin carboxylase C-terminal domain RE_HaeIII PF09556.10 PIK53061.1 - 0.055 12.5 0.0 5 6.1 0.0 2.2 2 0 0 2 2 2 0 HaeIII restriction endonuclease Fibrinogen_C PF00147.18 PIK53062.1 - 5.9e-71 238.8 6.8 2.1e-39 135.6 3.8 2.7 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53062.1 - 4.2e-09 36.2 29.3 6.1e-08 32.5 7.9 3.8 3 0 0 3 3 3 2 TILa domain EGF_3 PF12947.7 PIK53062.1 - 0.0047 17.1 15.3 0.0047 17.1 15.3 6.3 4 2 2 6 6 6 2 EGF domain CFC PF09443.10 PIK53062.1 - 2.6 8.0 8.2 2.4 8.1 1.1 3.1 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) Fibrinogen_C PF00147.18 PIK53063.1 - 7.4e-11 42.3 9.4 4.5e-10 39.7 9.4 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ANXA2R PF15721.5 PIK53063.1 - 0.021 15.4 0.5 0.022 15.3 0.5 1.1 1 0 0 1 1 1 0 Annexin-2 receptor VacA2 PF03077.14 PIK53063.1 - 0.042 13.7 0.5 0.084 12.7 0.5 1.5 1 0 0 1 1 1 0 Putative vacuolating cytotoxin Peptidase_S66 PF02016.15 PIK53065.1 - 0.024 14.7 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain V-set PF07686.17 PIK53066.1 - 0.0077 16.4 0.2 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK53066.1 - 0.071 13.3 0.0 0.18 12.0 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK53066.1 - 0.081 13.5 0.1 0.081 13.5 0.1 2.5 3 0 0 3 3 3 0 Immunoglobulin domain DUF4888 PF16229.5 PIK53066.1 - 0.11 12.4 0.0 5.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4888) HYR PF02494.16 PIK53066.1 - 0.16 12.3 3.5 2.9 8.3 0.4 2.3 2 0 0 2 2 2 0 HYR domain Tme5_EGF_like PF09064.10 PIK53066.1 - 0.99 9.4 11.5 3.4 7.6 3.2 2.9 2 2 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like ESCRT-II PF05871.12 PIK53067.1 - 2e-19 70.2 0.3 2.2e-19 70.1 0.3 1.0 1 0 0 1 1 1 1 ESCRT-II complex subunit DUF5082 PF16888.5 PIK53068.1 - 0.019 15.2 8.7 0.019 15.2 8.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) FlaC_arch PF05377.11 PIK53068.1 - 0.046 14.1 0.7 0.046 14.1 0.7 3.0 4 1 0 4 4 3 0 Flagella accessory protein C (FlaC) FAM76 PF16046.5 PIK53068.1 - 0.27 10.5 23.4 0.47 9.8 23.4 1.3 1 0 0 1 1 1 0 FAM76 protein Flagellin_N PF00669.20 PIK53068.1 - 0.42 10.7 7.3 0.094 12.8 1.8 2.3 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Rota_NSP4 PF01452.16 PIK53068.1 - 0.6 9.8 7.9 0.059 13.0 3.0 1.8 1 1 1 2 2 2 0 Rotavirus non structural protein Prominin PF05478.11 PIK53068.1 - 1 7.3 19.3 0.056 11.4 5.4 2.1 1 1 1 2 2 2 0 Prominin NPV_P10 PF05531.12 PIK53068.1 - 1.5 9.3 7.8 0.91 10.0 1.8 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 PIK53068.1 - 1.7 6.0 30.2 11 3.4 11.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4735 PF15882.5 PIK53068.1 - 1.8 7.9 14.8 0.036 13.5 5.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4735) Chal_sti_synt_N PF00195.19 PIK53068.1 - 2.8 7.3 5.1 0.31 10.4 1.0 1.6 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain DUF725 PF05267.12 PIK53068.1 - 3 7.9 7.2 1 9.4 1.4 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF725) Exonuc_VII_L PF02601.15 PIK53068.1 - 3.5 7.1 26.5 0.94 9.0 13.8 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit FAA_hydro_N_2 PF18288.1 PIK53068.1 - 4.8 7.7 6.6 1.8 9.0 0.3 2.7 1 1 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 PIN_8 PF18476.1 PIK53068.1 - 4.9 7.0 26.0 1.3 8.9 9.1 2.2 1 1 1 2 2 2 0 PIN like domain Malic_M PF03949.15 PIK53068.1 - 4.9 6.3 7.0 1.3 8.3 1.6 2.4 1 1 0 2 2 2 0 Malic enzyme, NAD binding domain MutS_III PF05192.18 PIK53068.1 - 9.3 6.4 15.1 14 5.9 14.9 1.6 1 1 0 1 1 1 0 MutS domain III TetR_C_24 PF17932.1 PIK53069.1 - 0.12 12.6 1.4 0.19 12.0 1.4 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Integrase_H2C2 PF17921.1 PIK53070.1 - 1.7e-20 72.8 0.4 2.8e-20 72.1 0.0 1.6 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK53070.1 - 3.3e-12 46.6 0.0 6.3e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK53070.1 - 0.0054 16.9 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK53071.1 - 1.1e-30 106.8 0.0 1.8e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK53071.1 - 6e-30 103.2 0.0 9.9e-30 102.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53071.1 - 8e-27 93.6 0.0 1.4e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PDEase_I PF00233.19 PIK53072.1 - 4.4e-81 272.1 8.3 5.6e-81 271.8 8.3 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Dna2 PF08696.11 PIK53075.1 - 1.6e-54 184.8 0.0 4.3e-54 183.4 0.0 1.7 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 PIK53075.1 - 2.4e-44 151.4 0.0 5.9e-44 150.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK53075.1 - 1.1e-31 110.6 7.8 6e-18 65.6 0.1 3.3 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 PIK53075.1 - 1.5e-13 51.0 0.0 2.8e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK53075.1 - 1.4e-11 44.9 0.0 3.5e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.7 PIK53075.1 - 0.00016 21.7 1.0 0.00019 21.4 0.0 1.6 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 PIK53075.1 - 0.00049 19.9 5.7 0.8 9.4 0.0 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 PIK53075.1 - 0.0081 16.0 0.0 0.027 14.3 0.0 2.1 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 PIK53075.1 - 0.0086 15.6 0.0 0.0086 15.6 0.0 3.1 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 PIK53075.1 - 0.014 14.9 0.0 0.038 13.4 0.0 1.7 1 1 0 1 1 1 0 PhoH-like protein PIF1 PF05970.14 PIK53075.1 - 0.029 13.5 0.0 0.12 11.5 0.0 2.0 1 1 0 1 1 1 0 PIF1-like helicase AAA_18 PF13238.6 PIK53075.1 - 0.03 14.9 0.7 0.18 12.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 PIK53075.1 - 0.035 13.7 0.7 0.065 12.9 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 PIK53075.1 - 0.046 14.1 0.5 0.19 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain UvrD_C_2 PF13538.6 PIK53075.1 - 0.049 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA PF00004.29 PIK53075.1 - 0.086 13.3 0.3 0.33 11.4 0.1 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 PIK53075.1 - 0.13 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RRS1 PF04939.12 PIK53075.1 - 3.4 7.5 5.2 3.6 7.4 0.4 2.5 2 0 0 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) RhoGEF PF00621.20 PIK53076.1 - 1.1e-36 126.7 1.2 1.1e-36 126.7 1.2 4.4 4 1 0 4 4 4 1 RhoGEF domain Spectrin PF00435.21 PIK53076.1 - 8.4e-34 116.2 75.5 1.5e-11 44.7 1.4 9.8 9 1 1 10 10 10 6 Spectrin repeat PH PF00169.29 PIK53076.1 - 1.8e-08 34.9 1.3 1.4e-07 32.0 0.3 2.9 2 0 0 2 2 2 1 PH domain PH_10 PF15411.6 PIK53076.1 - 1.5e-06 28.4 0.0 6.4e-06 26.4 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain CRAL_TRIO PF00650.20 PIK53076.1 - 0.00026 20.8 0.0 0.00078 19.2 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO domain IQ_SEC7_PH PF16453.5 PIK53076.1 - 0.0024 17.9 0.5 0.073 13.0 0.1 3.1 2 0 0 2 2 2 1 PH domain Ribosomal_L17 PF01196.19 PIK53076.1 - 0.073 14.0 4.0 2.6 9.0 0.1 3.7 3 0 0 3 3 3 0 Ribosomal protein L17 HEPN_AbiV PF18728.1 PIK53076.1 - 0.69 10.0 5.8 3.3 7.9 0.0 3.4 3 0 0 3 3 3 0 AbiV RhoGEF PF00621.20 PIK53077.1 - 2.6e-36 125.6 2.3 8e-36 124.0 1.1 2.2 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 PIK53077.1 - 1.6e-08 35.0 0.0 5.2e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 PIK53077.1 - 2.6e-05 24.5 0.0 0.00021 21.5 0.0 2.6 1 1 1 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 PIK53077.1 - 0.073 13.0 0.0 0.24 11.4 0.0 1.9 1 0 0 1 1 1 0 PH domain Ras PF00071.22 PIK53078.1 - 2.3e-43 147.6 0.1 2.8e-43 147.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK53078.1 - 1.6e-28 99.4 0.2 2e-28 99.0 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK53078.1 - 4.6e-15 55.5 0.1 5.5e-15 55.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK53078.1 - 8.6e-06 25.3 0.1 1e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK53078.1 - 0.00063 19.2 0.0 0.00082 18.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 PIK53078.1 - 0.011 15.5 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 PIK53078.1 - 0.025 13.8 2.4 0.39 9.8 2.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit TniB PF05621.11 PIK53078.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein PH_9 PF15410.6 PIK53079.1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain Spc7 PF08317.11 PIK53080.1 - 2.1e-05 23.6 26.2 7.2e-05 21.8 16.3 2.3 2 0 0 2 2 2 2 Spc7 kinetochore protein APG6_N PF17675.1 PIK53080.1 - 0.0046 17.5 7.1 0.0046 17.5 7.1 3.1 2 1 1 3 3 3 1 Apg6 coiled-coil region YabA PF06156.13 PIK53080.1 - 0.0068 17.0 19.6 0.053 14.1 5.8 3.4 2 1 1 3 3 3 1 Initiation control protein YabA ATG16 PF08614.11 PIK53080.1 - 0.013 15.7 30.3 0.19 11.9 0.4 3.3 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) KELK PF15796.5 PIK53080.1 - 0.1 13.0 0.5 0.1 13.0 0.5 3.9 3 1 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase GNT-I PF03071.15 PIK53080.1 - 0.18 10.5 2.6 0.29 9.9 2.6 1.5 1 0 0 1 1 1 0 GNT-I family TACC_C PF05010.14 PIK53080.1 - 0.24 11.2 27.1 0.061 13.1 18.5 2.5 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal CENP-F_leu_zip PF10473.9 PIK53080.1 - 0.94 9.5 33.3 1.4 8.9 3.1 3.1 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 PIK53080.1 - 1.4 9.1 33.1 9.4 6.4 21.6 3.1 2 1 0 2 2 2 0 Tropomyosin like DUF1664 PF07889.12 PIK53080.1 - 1.8 8.6 18.2 3.6 7.6 6.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 PIK53080.1 - 2.9 7.6 29.6 2.5 7.8 14.6 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 PIK53080.1 - 2.9 7.9 40.3 6.2 6.9 25.3 3.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF16 PF01519.16 PIK53080.1 - 3 8.4 22.0 0.41 11.2 0.4 3.6 2 1 0 2 2 1 0 Protein of unknown function DUF16 HAP1_N PF04849.13 PIK53080.1 - 3.6 6.7 28.8 1.8 7.7 17.6 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF812 PF05667.11 PIK53080.1 - 3.9 6.2 33.3 0.17 10.8 1.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF812) DUF745 PF05335.13 PIK53080.1 - 4.2 7.1 23.4 0.59 9.8 16.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) THOC7 PF05615.13 PIK53080.1 - 4.6 7.5 30.3 3 8.1 1.3 3.2 2 1 1 3 3 3 0 Tho complex subunit 7 Vac_Fusion PF02346.16 PIK53080.1 - 5 6.8 8.6 11 5.7 0.3 3.6 4 0 0 4 4 3 0 Chordopoxvirus multifunctional envelope protein A27 Rotamase PF00639.21 PIK53080.1 - 5.9 7.9 15.3 5.3 8.1 0.9 3.2 2 1 1 3 3 3 0 PPIC-type PPIASE domain COG2 PF06148.11 PIK53080.1 - 8 6.5 21.9 13 5.9 12.7 3.4 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind PF09278.11 PIK53080.1 - 8.4 7.0 12.4 36 5.0 5.9 3.4 2 2 1 3 3 3 0 MerR, DNA binding GAS PF13851.6 PIK53080.1 - 8.5 5.7 35.3 5.8 6.2 17.2 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding SKA1 PF07160.12 PIK53080.1 - 8.8 6.1 23.8 0.44 10.3 0.6 3.0 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 1 Yuri_gagarin PF15934.5 PIK53080.1 - 8.8 6.1 24.8 9.6 6.0 2.8 2.2 2 0 0 2 2 2 0 Yuri gagarin TMF_TATA_bd PF12325.8 PIK53080.1 - 9.8 6.4 32.1 1.6 9.0 15.2 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding p450 PF00067.22 PIK53081.1 - 1.1e-57 195.8 0.8 1.3e-57 195.6 0.8 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1633 PF07794.11 PIK53081.1 - 0.15 10.2 0.0 0.21 9.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) zf-C2HC_2 PF13913.6 PIK53082.1 - 8e-06 25.6 2.6 1.2e-05 25.1 2.6 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type Etmic-2 PF06670.11 PIK53082.1 - 0.0011 18.1 0.0 0.0013 17.7 0.0 1.0 1 0 0 1 1 1 1 Microneme protein Etmic-2 Nairovirus_M PF07948.11 PIK53082.1 - 0.04 12.1 0.3 0.049 11.9 0.3 1.1 1 0 0 1 1 1 0 Nairovirus M polyprotein-like zf-CHCC PF10276.9 PIK53082.1 - 0.097 12.7 1.3 0.16 12.0 1.3 1.3 1 0 0 1 1 1 0 Zinc-finger domain zf-C2H2_4 PF13894.6 PIK53082.1 - 0.18 12.7 2.5 0.34 11.9 1.4 2.2 2 1 0 2 2 2 0 C2H2-type zinc finger ATP_bind_3 PF01171.20 PIK53083.1 - 0.18 11.5 2.8 1.4 8.6 0.0 2.1 2 0 0 2 2 2 0 PP-loop family CAF20 PF17052.5 PIK53083.1 - 1.7 8.7 12.4 1.4 9.0 1.8 2.3 1 1 1 2 2 2 0 Cap associated factor DUF5407 PF17401.2 PIK53086.1 - 0.023 14.9 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5407) DAN PF03045.15 PIK53087.1 - 3e-36 123.9 5.4 4e-36 123.5 5.4 1.1 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 PIK53087.1 - 0.00066 20.0 6.8 0.00094 19.4 6.8 1.2 1 0 0 1 1 1 1 Cystine-knot domain Glycos_transf_2 PF00535.26 PIK53088.1 - 8.3e-25 87.5 0.0 1.7e-24 86.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK53088.1 - 1.6e-16 60.7 0.6 3.2e-16 59.7 0.6 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 PIK53088.1 - 3.4e-05 23.5 0.0 5.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 PIK53088.1 - 4.1e-05 23.2 0.0 9.7e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Zip PF02535.22 PIK53089.1 - 2.7e-37 128.8 21.5 1.8e-31 109.6 9.6 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter DUF996 PF06195.13 PIK53089.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.2 2 2 1 3 3 3 0 Protein of unknown function (DUF996) ASFV_L11L PF05293.11 PIK53089.1 - 0.15 12.4 0.0 0.57 10.5 0.0 1.9 1 0 0 1 1 1 0 African swine fever virus (ASFV) L11L protein Claudin_2 PF13903.6 PIK53089.1 - 1 9.1 5.7 2.2 8.0 0.5 2.9 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction ER PF01133.17 PIK53090.1 - 7.5e-40 134.9 0.1 8.4e-40 134.8 0.1 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary BTB PF00651.31 PIK53091.1 - 2.2e-25 89.0 0.2 2.4e-14 53.5 0.0 3.3 3 1 0 3 3 3 2 BTB/POZ domain BACK PF07707.15 PIK53091.1 - 2.5e-05 24.3 3.1 5.9e-05 23.1 0.3 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF5473 PF17567.2 PIK53091.1 - 0.028 14.7 0.8 0.1 12.9 0.8 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5473) PAS PF00989.25 PIK53092.1 - 5.5e-09 36.0 0.0 9.2e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 PIK53092.1 - 0.0025 18.1 0.0 0.0038 17.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 PIK53092.1 - 0.0035 17.6 0.0 0.0071 16.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 PIK53092.1 - 0.028 14.7 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 PAS fold PAS_2 PF08446.11 PIK53092.1 - 0.076 13.7 0.0 0.24 12.1 0.0 1.9 2 1 0 2 2 2 0 PAS fold PAS_11 PF14598.6 PIK53093.1 - 7.4e-18 64.7 0.1 1.5e-17 63.8 0.1 1.5 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 PIK53093.1 - 6.3e-15 55.2 0.0 1.3e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 PIK53093.1 - 0.00028 20.9 0.0 0.00063 19.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 PIK53093.1 - 0.00046 20.4 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 PIK53093.1 - 0.034 14.4 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 PAS fold Pacs-1 PF10254.9 PIK53094.1 - 1.1e-91 307.9 0.0 1.1e-91 307.9 0.0 1.8 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein AF-4 PF05110.13 PIK53095.1 - 0.097 10.8 5.4 0.12 10.5 5.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMUP PF15761.5 PIK53095.1 - 1.5 9.5 4.7 2.3 9.0 4.7 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein Choline_transpo PF04515.12 PIK53096.1 - 2.9e-94 315.9 28.7 3.3e-94 315.7 28.7 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter BPD_transp_1 PF00528.22 PIK53096.1 - 0.53 10.0 18.0 3 7.5 5.5 3.1 3 0 0 3 3 3 0 Binding-protein-dependent transport system inner membrane component Tmem26 PF09772.9 PIK53097.1 - 1.3e-69 234.8 10.7 1.6e-69 234.5 10.7 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 Exo_endo_phos_2 PF14529.6 PIK53099.1 - 1.1e-05 25.3 0.2 4.3e-05 23.4 0.2 2.1 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Sulfatase PF00884.23 PIK53100.1 - 2.4e-24 86.3 0.0 3.2e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK53100.1 - 0.00042 20.0 0.0 0.00048 19.8 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Gal_Lectin PF02140.18 PIK53101.1 - 8.1e-13 48.6 2.1 1.4e-12 47.8 2.1 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain Gal_Lectin PF02140.18 PIK53102.1 - 2.5e-23 82.3 2.0 3.8e-23 81.7 2.0 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain AA_permease_2 PF13520.6 PIK53103.1 - 1.3e-15 57.1 9.8 1.6e-15 56.9 9.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK53103.1 - 2.8e-06 26.2 8.4 3.4e-06 25.9 8.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4013 PF13197.6 PIK53103.1 - 0.014 15.2 8.4 0.019 14.8 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) Trp_Tyr_perm PF03222.13 PIK53103.1 - 0.024 13.7 6.2 0.029 13.4 6.2 1.1 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family Pkinase PF00069.25 PIK53104.1 - 0.027 13.9 0.0 0.028 13.8 0.0 1.0 1 0 0 1 1 1 0 Protein kinase domain CPSase_L_D2 PF02786.17 PIK53105.1 - 1.4e-62 210.9 0.2 9.3e-62 208.3 0.2 2.1 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 PIK53105.1 - 4e-45 152.9 0.0 1.1e-44 151.4 0.0 1.8 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 PIK53105.1 - 7.1e-38 129.0 0.0 2.5e-37 127.3 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 PIK53105.1 - 5.2e-25 88.2 0.1 9.5e-25 87.4 0.1 1.5 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl PF00364.22 PIK53105.1 - 2.2e-16 59.4 3.2 6.2e-16 58.0 3.2 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 PIK53105.1 - 1.6e-05 24.6 1.4 0.15 11.9 0.6 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 PIK53105.1 - 0.0034 17.3 1.4 0.018 15.0 1.4 2.3 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 PIK53105.1 - 0.047 14.4 0.6 0.39 11.4 0.0 2.5 3 0 0 3 3 3 0 HlyD family secretion protein Epimerase PF01370.21 PIK53106.1 - 1.4e-24 86.9 0.0 2.1e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK53106.1 - 3.2e-24 85.4 0.0 4.1e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK53106.1 - 1.6e-15 57.5 0.0 2.5e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 PIK53106.1 - 4e-14 52.8 0.0 6e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK53106.1 - 3.7e-13 49.3 0.0 1.1e-12 47.6 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 PIK53106.1 - 2.1e-08 34.0 0.0 3.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 PIK53106.1 - 1.5e-05 24.3 0.0 2.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK53106.1 - 7.7e-05 22.7 0.0 0.0002 21.3 0.0 1.6 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 PIK53106.1 - 0.0013 18.2 0.0 0.0043 16.5 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK53106.1 - 0.0097 15.0 0.1 0.015 14.4 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 PIK53107.1 - 3.2e-15 55.9 0.0 4.2e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK53107.1 - 3e-14 53.1 0.0 3.9e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK53107.1 - 3.2e-12 46.7 0.0 4.4e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 PIK53107.1 - 3.6e-08 33.2 0.0 4.9e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 PIK53107.1 - 1.3e-06 28.2 0.0 1.5e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 PIK53107.1 - 1.8e-06 27.3 0.0 0.012 14.9 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 PIK53107.1 - 0.00025 20.3 0.0 0.00033 19.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK53107.1 - 0.036 14.0 0.1 1 9.3 0.1 2.1 1 1 0 1 1 1 0 KR domain RmlD_sub_bind PF04321.17 PIK53107.1 - 0.087 11.9 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.21 PIK53109.1 - 7.4e-18 64.9 0.1 4e-13 49.4 0.0 2.2 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK53109.1 - 1.8e-13 50.1 0.1 1.5e-11 43.9 0.0 2.0 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 PIK53109.1 - 3.2e-08 33.0 0.0 7.3e-06 25.3 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 PIK53109.1 - 4e-07 29.7 0.2 0.0019 17.7 0.0 2.2 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 PIK53109.1 - 6e-05 23.0 0.1 0.04 13.8 0.0 2.2 1 1 1 2 2 2 2 NAD(P)H-binding NmrA PF05368.13 PIK53109.1 - 0.0011 18.6 0.2 0.025 14.1 0.1 2.5 2 1 1 3 3 3 1 NmrA-like family KR PF08659.10 PIK53109.1 - 0.037 13.9 0.1 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 KR domain 3Beta_HSD PF01073.19 PIK53110.1 - 5.3e-11 42.1 0.0 8.7e-10 38.1 0.0 2.0 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK53110.1 - 6.6e-09 35.6 0.1 1.6e-06 27.8 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK53110.1 - 8.2e-08 32.3 0.0 1.6e-07 31.4 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 PIK53110.1 - 7.1e-05 22.1 0.0 0.00012 21.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PK_C PF02887.16 PIK53110.1 - 0.0038 17.5 0.0 0.58 10.4 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain KR PF08659.10 PIK53110.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.5 1 1 0 1 1 1 0 KR domain MFS_1 PF07690.16 PIK53111.1 - 2.5e-06 26.7 3.9 2.8e-06 26.5 3.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK53111.1 - 0.019 13.9 0.0 0.021 13.7 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Flp_Fap PF04964.14 PIK53112.1 - 0.0026 17.5 0.1 0.0054 16.5 0.1 1.5 1 0 0 1 1 1 1 Flp/Fap pilin component DUF5526 PF17664.1 PIK53112.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5526) Frizzled PF01534.17 PIK53113.1 - 1.1e-125 419.1 18.8 1.3e-125 418.8 18.8 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 PIK53113.1 - 7.2e-31 107.1 4.0 1.4e-30 106.2 4.0 1.5 1 0 0 1 1 1 1 Fz domain Ank_2 PF12796.7 PIK53114.1 - 3.6e-14 53.1 0.4 1.2e-13 51.4 0.4 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK53114.1 - 6.8e-12 45.7 0.3 9e-06 26.1 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK53114.1 - 1.4e-11 44.2 0.7 3.7e-05 24.0 0.1 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 PIK53114.1 - 2.3e-10 40.5 1.0 3.5e-05 24.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK53114.1 - 6e-08 32.3 0.1 0.013 15.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat FAP206 PF12018.8 PIK53115.1 - 0.077 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function Med9 PF07544.13 PIK53115.1 - 0.82 9.8 7.0 0.9 9.7 0.8 3.1 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 KH_1 PF00013.29 PIK53116.1 - 3.5e-07 30.0 0.0 5.7e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 KH domain Pro_isomerase PF00160.21 PIK53117.1 - 9.7e-43 146.2 0.0 1.4e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PX PF00787.24 PIK53118.1 - 5.1e-29 100.5 0.1 6.3e-29 100.3 0.1 1.1 1 0 0 1 1 1 1 PX domain Pox_Rif PF03340.13 PIK53118.1 - 0.2 10.1 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus rifampicin resistance protein MARVEL PF01284.23 PIK53119.1 - 3.8e-15 56.2 4.1 4.7e-15 55.9 4.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain Serinc PF03348.15 PIK53119.1 - 0.035 13.0 4.5 0.049 12.5 4.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2909 PF11137.8 PIK53119.1 - 0.038 13.9 0.4 0.075 13.0 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) AA_permease PF00324.21 PIK53119.1 - 0.053 12.1 8.1 0.068 11.8 8.1 1.1 1 0 0 1 1 1 0 Amino acid permease Cation_ATPase_C PF00689.21 PIK53119.1 - 0.38 10.4 9.0 0.42 10.3 8.3 1.3 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF4728 PF15860.5 PIK53119.1 - 0.67 10.7 4.4 1.1 9.9 2.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) DUF5090 PF17009.5 PIK53119.1 - 2.5 8.0 6.5 1.8 8.5 4.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5090) Sushi PF00084.20 PIK53121.1 - 2e-58 194.8 86.9 1.9e-06 28.4 1.3 13.5 13 1 1 14 14 14 12 Sushi repeat (SCR repeat) Colicin_Pyocin PF01320.18 PIK53121.1 - 0.012 15.7 0.0 59 3.9 0.0 4.6 5 0 0 5 5 5 0 Colicin immunity protein / pyocin immunity protein GSIII_N PF12437.8 PIK53121.1 - 0.18 11.4 0.0 56 3.4 0.0 3.4 5 0 0 5 5 5 0 Glutamine synthetase type III N terminal DUF3938 PF13074.6 PIK53121.1 - 0.27 11.5 5.5 81 3.6 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF3938) Antistasin PF02822.14 PIK53121.1 - 1.1 9.9 31.1 1.3e+02 3.4 0.1 12.8 15 0 0 15 15 15 0 Antistasin family Sushi PF00084.20 PIK53122.1 - 3e-28 98.2 25.0 9.3e-06 26.1 1.0 5.3 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) TMCCDC2 PF15844.5 PIK53122.1 - 0.012 15.6 5.1 4.7 7.1 0.1 3.2 3 0 0 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 Antistasin PF02822.14 PIK53122.1 - 0.016 15.9 12.3 43 4.9 0.0 7.7 7 0 0 7 7 7 0 Antistasin family cEGF PF12662.7 PIK53122.1 - 0.025 14.5 21.9 7 6.7 0.5 5.7 5 0 0 5 5 5 0 Complement Clr-like EGF-like Haemadin PF09065.10 PIK53122.1 - 0.027 14.3 11.1 61 3.5 0.1 7.0 8 0 0 8 8 8 0 Haemadin GSIII_N PF12437.8 PIK53122.1 - 0.062 13.0 0.0 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Glutamine synthetase type III N terminal Connexin PF00029.19 PIK53122.1 - 0.24 11.1 4.5 26 4.5 0.1 4.1 4 0 0 4 4 4 0 Connexin CBM_14 PF01607.24 PIK53122.1 - 0.3 11.3 9.8 39 4.5 0.1 5.0 5 0 0 5 5 5 0 Chitin binding Peritrophin-A domain Big_11 PF18200.1 PIK53122.1 - 0.31 11.0 1.8 22 5.1 0.1 3.1 5 0 0 5 5 5 0 Bacterial Ig-like domain FXa_inhibition PF14670.6 PIK53122.1 - 4 7.8 14.9 75 3.7 0.1 5.9 5 0 0 5 5 5 0 Coagulation Factor Xa inhibitory site Sushi PF00084.20 PIK53123.1 - 5.8e-51 170.9 53.3 3.4e-05 24.3 0.6 10.2 10 0 0 10 10 10 10 Sushi repeat (SCR repeat) Big_11 PF18200.1 PIK53123.1 - 2e-06 27.6 3.5 37 4.3 0.0 6.5 6 0 0 6 6 6 0 Bacterial Ig-like domain Legionella_OMP PF05150.12 PIK53123.1 - 4.8e-06 25.7 0.0 30 3.4 0.0 7.1 8 1 1 9 9 9 0 Legionella pneumophila major outer membrane protein precursor TMCCDC2 PF15844.5 PIK53123.1 - 0.028 14.3 1.1 11 6.0 0.1 2.9 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 CDH-cyt PF16010.5 PIK53123.1 - 0.15 11.7 8.2 18 5.0 0.2 6.2 5 2 0 6 6 6 0 Cytochrome domain of cellobiose dehydrogenase Connexin PF00029.19 PIK53123.1 - 1.1 9.0 19.2 33 4.1 0.0 7.3 8 0 0 8 8 8 0 Connexin cEGF PF12662.7 PIK53123.1 - 1.1 9.2 32.7 45 4.1 0.2 8.4 8 0 0 8 8 8 0 Complement Clr-like EGF-like Sushi PF00084.20 PIK53124.1 - 1.6e-133 435.3 171.3 7.7e-07 29.6 4.1 31.1 31 0 0 31 31 31 29 Sushi repeat (SCR repeat) Big_11 PF18200.1 PIK53124.1 - 1.7e-20 72.7 17.9 95 3.0 0.0 21.6 22 0 0 22 22 22 0 Bacterial Ig-like domain cEGF PF12662.7 PIK53124.1 - 0.031 14.2 54.5 8 6.5 0.6 12.5 11 0 0 11 11 11 0 Complement Clr-like EGF-like NPDC1 PF06809.11 PIK53124.1 - 1.9 7.5 5.8 49 2.8 0.0 4.0 4 0 0 4 4 4 0 Neural proliferation differentiation control-1 protein (NPDC1) RVT_1 PF00078.27 PIK53126.1 - 7.8e-34 117.1 0.0 2.7e-28 99.0 0.0 2.0 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) T3SS_ExsE PF18286.1 PIK53126.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Type III secretion system ExsE VWD PF00094.25 PIK53127.1 - 1.7e-110 366.3 22.6 2.1e-30 106.1 0.8 5.2 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.11 PIK53127.1 - 3.6e-44 149.0 29.8 5.5e-16 58.8 1.5 9.1 10 2 1 11 11 11 4 C8 domain TILa PF12714.7 PIK53127.1 - 1.3e-18 66.7 59.9 4.3e-08 33.0 11.3 9.6 10 1 0 10 10 10 4 TILa domain EGF_3 PF12947.7 PIK53127.1 - 1e-11 44.8 38.3 1.6e-06 28.2 7.9 12.5 10 3 2 12 12 12 4 EGF domain TIL PF01826.17 PIK53127.1 - 1.8e-11 44.1 32.2 1e-08 35.3 17.9 16.0 10 5 7 17 17 17 3 Trypsin Inhibitor like cysteine rich domain EGF PF00008.27 PIK53127.1 - 1e-09 38.5 30.5 3.4e-06 27.2 8.5 12.7 11 2 1 12 12 12 2 EGF-like domain EGF_MSP1_1 PF12946.7 PIK53127.1 - 3.1e-06 27.1 6.9 3.1e-06 27.1 6.9 10.1 10 0 0 10 10 10 4 MSP1 EGF domain 1 hEGF PF12661.7 PIK53127.1 - 0.00013 22.5 25.8 0.00018 22.0 8.5 14.1 13 3 1 14 14 14 2 Human growth factor-like EGF cEGF PF12662.7 PIK53127.1 - 0.0024 17.8 5.7 0.0024 17.8 5.7 11.4 12 0 0 12 12 12 4 Complement Clr-like EGF-like C8 PF08742.11 PIK53128.1 - 6.8e-16 58.5 0.3 6.8e-16 58.5 0.3 2.4 2 1 0 2 2 2 1 C8 domain VWD PF00094.25 PIK53128.1 - 2.7e-14 53.7 0.1 4e-14 53.2 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type D domain CLCA PF08434.11 PIK53129.1 - 1.4e-57 195.1 0.2 2.1e-57 194.5 0.2 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK53129.1 - 1.4e-08 35.2 0.3 2.6e-08 34.3 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 PIK53129.1 - 5.6e-08 32.9 0.0 9.1e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK53129.1 - 1.8e-06 28.5 0.0 4.5e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain GRP PF07172.11 PIK53129.1 - 0.0037 17.9 0.0 0.01 16.5 0.0 1.8 1 0 0 1 1 1 1 Glycine rich protein family Herpes_gE PF02480.16 PIK53129.1 - 0.033 12.9 0.0 3.2 6.4 0.0 2.2 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 PIK53129.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF3810 PF12725.7 PIK53129.1 - 0.094 12.0 0.2 4.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Invasin_D3 PF09134.10 PIK53129.1 - 0.56 10.5 3.1 14 6.1 0.1 3.2 3 0 0 3 3 3 0 Invasin, domain 3 Syndecan PF01034.20 PIK53129.1 - 0.63 10.0 2.2 1.3 9.0 2.2 1.4 1 0 0 1 1 1 0 Syndecan domain Gram_pos_anchor PF00746.21 PIK53129.1 - 0.64 10.0 2.0 1.8 8.6 2.0 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Fibrinogen_C PF00147.18 PIK53130.1 - 2.5e-60 204.1 6.7 3e-60 203.8 6.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK53130.1 - 0.0022 17.3 0.3 0.0031 16.9 0.3 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Fibrinogen_C PF00147.18 PIK53131.1 - 2e-60 204.4 2.5 3.3e-60 203.6 2.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain VWD PF00094.25 PIK53131.1 - 2.5e-17 63.6 0.0 5.1e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK53131.1 - 4.5e-15 55.8 3.4 4.5e-15 55.8 3.4 3.8 2 2 1 3 3 3 1 C8 domain TIL PF01826.17 PIK53131.1 - 6.1e-12 45.6 30.4 5.6e-08 32.9 16.8 7.3 5 2 2 7 7 7 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK53131.1 - 2.7e-11 43.2 12.7 2.7e-11 43.2 12.7 6.2 3 2 2 5 5 5 1 TILa domain EGF_3 PF12947.7 PIK53131.1 - 8.8e-05 22.6 31.6 0.00025 21.2 11.7 6.2 5 1 1 6 6 6 2 EGF domain EGF_MSP1_1 PF12946.7 PIK53131.1 - 0.0037 17.3 3.6 0.0037 17.3 3.6 5.0 5 0 0 5 5 5 2 MSP1 EGF domain 1 VWD PF00094.25 PIK53132.1 - 3.1e-86 287.5 18.1 2.1e-28 99.6 0.8 4.3 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.11 PIK53132.1 - 5.4e-49 164.5 31.4 3.8e-16 59.3 1.3 7.3 7 2 1 8 8 8 4 C8 domain TILa PF12714.7 PIK53132.1 - 1.7e-24 85.5 41.3 2.6e-11 43.3 7.7 8.5 6 2 2 8 8 8 3 TILa domain TIL PF01826.17 PIK53132.1 - 6.5e-18 64.7 58.9 5.8e-10 39.3 17.1 11.8 11 4 1 12 12 12 3 Trypsin Inhibitor like cysteine rich domain VWD PF00094.25 PIK53133.1 - 2.4e-85 284.6 16.5 1.2e-31 110.1 0.8 4.2 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.11 PIK53133.1 - 3.3e-36 123.5 14.7 1.4e-14 54.3 0.5 7.6 7 2 0 7 7 7 3 C8 domain TILa PF12714.7 PIK53133.1 - 1.4e-14 53.8 45.3 2.4e-08 33.8 8.9 8.9 6 2 2 8 8 8 3 TILa domain EGF PF00008.27 PIK53133.1 - 3.3e-13 49.7 30.0 7e-09 35.8 9.2 12.8 9 2 3 12 12 12 2 EGF-like domain EGF_3 PF12947.7 PIK53133.1 - 1.7e-12 47.3 38.9 1.2e-06 28.5 7.9 10.2 9 2 1 10 10 10 3 EGF domain TIL PF01826.17 PIK53133.1 - 2e-11 44.0 43.3 9.4e-08 32.2 17.7 13.8 10 5 4 14 14 14 3 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.7 PIK53133.1 - 1.7e-06 28.4 25.8 5.8e-06 26.7 9.4 13.2 12 1 1 13 13 13 2 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK53133.1 - 2.4e-06 27.5 6.9 2.4e-06 27.5 6.9 7.9 7 0 0 7 7 7 3 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK53133.1 - 0.0028 18.0 13.5 0.0028 18.0 13.5 15.9 15 2 2 18 18 18 2 EGF-like domain cEGF PF12662.7 PIK53133.1 - 0.0055 16.6 6.9 0.0055 16.6 6.9 10.7 10 0 0 10 10 10 5 Complement Clr-like EGF-like CLCA PF08434.11 PIK53135.1 - 7.4e-58 196.0 0.2 1e-57 195.5 0.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK53135.1 - 4.5e-09 36.8 0.3 7.8e-09 36.0 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 PIK53135.1 - 2.9e-06 27.3 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK53135.1 - 1.5e-05 25.5 0.0 3.5e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4448 PF14610.6 PIK53135.1 - 0.029 14.2 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Invasin_D3 PF09134.10 PIK53135.1 - 0.034 14.5 0.4 15 6.0 0.1 2.7 2 0 0 2 2 2 0 Invasin, domain 3 DUF4734 PF15881.5 PIK53135.1 - 0.073 13.2 0.1 0.75 10.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) ig PF00047.25 PIK53136.1 - 0.00027 21.0 2.7 0.00027 21.0 2.7 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK53136.1 - 0.0016 18.5 0.5 0.15 12.2 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53136.1 - 0.0063 17.1 3.5 0.02 15.5 1.4 2.2 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK53136.1 - 0.041 14.0 0.9 0.4 10.9 0.3 2.2 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK53136.1 - 0.59 10.5 5.1 0.45 10.9 3.1 1.8 2 0 0 2 2 2 0 Immunoglobulin domain FANCL_C PF11793.8 PIK53136.1 - 1 9.6 5.9 0.9 9.8 2.3 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain Lep_receptor_Ig PF06328.11 PIK53136.1 - 3 7.9 7.9 9.2 6.3 3.6 2.9 1 1 1 2 2 2 0 Ig-like C2-type domain Mito_carr PF00153.27 PIK53137.1 - 4e-59 196.5 2.9 4.9e-22 77.7 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein C2 PF00168.30 PIK53138.1 - 2.4e-11 43.8 0.0 3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK53139.1 - 2e-25 89.0 0.1 1.3e-24 86.5 0.0 2.1 2 0 0 2 2 2 1 C2 domain CEP76-C2 PF15627.6 PIK53139.1 - 0.00013 21.5 0.6 0.00023 20.7 0.0 1.6 2 0 0 2 2 2 1 CEP76 C2 domain DUF3149 PF11346.8 PIK53139.1 - 0.02 14.5 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DOCK-C2 PF14429.6 PIK53139.1 - 0.076 12.8 1.6 0.24 11.2 0.1 2.0 1 1 1 2 2 2 0 C2 domain in Dock180 and Zizimin proteins C2 PF00168.30 PIK53140.1 - 2.3e-25 88.8 0.1 1.5e-24 86.3 0.0 2.1 2 0 0 2 2 2 1 C2 domain CEP76-C2 PF15627.6 PIK53140.1 - 0.00017 21.2 0.8 0.00026 20.6 0.1 1.7 2 0 0 2 2 2 1 CEP76 C2 domain DUF3149 PF11346.8 PIK53140.1 - 0.022 14.3 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DOCK-C2 PF14429.6 PIK53140.1 - 0.083 12.7 1.8 0.19 11.5 0.2 2.2 1 1 1 2 2 2 0 C2 domain in Dock180 and Zizimin proteins kleA_kleC PF17383.2 PIK53141.1 - 0.0094 16.3 0.5 0.0094 16.3 0.5 5.1 5 1 1 6 6 6 1 Uncharacterized KorC regulated protein A Transglut_core PF01841.19 PIK53142.1 - 1.9e-14 54.1 0.3 3.9e-14 53.0 0.3 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.20 PIK53142.1 - 8.7e-09 35.8 0.0 1.7e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase family zf-C3HC4 PF00097.25 PIK53143.1 - 1.2e-09 37.8 8.1 1.2e-09 37.8 8.1 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK53143.1 - 2e-09 37.3 6.8 2e-09 37.3 6.8 3.2 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK53143.1 - 9.2e-08 31.8 12.5 9.2e-08 31.8 12.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK53143.1 - 4.1e-07 30.2 8.6 4.1e-07 30.2 8.6 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK53143.1 - 6.7e-07 29.4 10.2 6.7e-07 29.4 10.2 3.7 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK53143.1 - 9.8e-06 25.3 8.8 9.8e-06 25.3 8.8 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK53143.1 - 4.4e-05 23.3 7.3 4.4e-05 23.3 7.3 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK53143.1 - 0.00041 20.4 28.5 0.003 17.7 13.6 3.9 4 0 0 4 4 4 2 B-box zinc finger AAA_10 PF12846.7 PIK53143.1 - 0.049 12.5 0.1 0.077 11.9 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain Laminin_EGF PF00053.24 PIK53145.1 - 0.017 15.2 24.8 3.9 7.7 0.8 3.8 2 2 1 3 3 3 0 Laminin EGF domain EGF PF00008.27 PIK53145.1 - 0.022 15.0 1.4 0.022 15.0 1.4 4.9 5 1 0 5 5 5 0 EGF-like domain NDUF_B8 PF05821.11 PIK53146.1 - 3e-46 157.5 4.8 3.5e-46 157.3 4.8 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Lipase_3 PF01764.25 PIK53148.1 - 1.9e-07 31.1 0.0 3.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF5630 PF18632.1 PIK53148.1 - 0.16 11.3 0.1 0.27 10.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5630) PPP1R32 PF15691.5 PIK53151.1 - 7.6e-147 489.8 10.1 9e-147 489.5 10.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 32 Sec23_trunk PF04811.15 PIK53152.1 - 1.7e-07 31.1 0.0 0.00034 20.3 0.0 2.5 2 0 0 2 2 2 2 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 PIK53152.1 - 1.3e-05 25.2 0.1 2.6e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger VWA_2 PF13519.6 PIK53152.1 - 2.9e-05 24.7 0.2 0.04 14.6 0.2 3.6 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK53152.1 - 0.0037 16.7 0.1 1.6 8.1 0.0 2.3 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein VCX_VCY PF15231.6 PIK53152.1 - 0.12 13.1 0.3 0.28 11.9 0.3 1.6 1 0 0 1 1 1 0 Variable charge X/Y family VWA PF00092.28 PIK53152.1 - 0.15 12.3 0.4 10 6.4 0.0 3.0 3 0 0 3 3 3 0 von Willebrand factor type A domain Tap-RNA_bind PF09162.10 PIK53153.1 - 0.092 12.6 0.1 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Tap, RNA-binding Svf1 PF08622.10 PIK53154.1 - 0.11 12.6 0.3 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Svf1-like N-terminal lipocalin domain TnpV PF14198.6 PIK53155.1 - 2.2 8.3 7.3 1.4 8.9 3.1 2.1 1 1 1 2 2 2 0 Transposon-encoded protein TnpV zf-H2C2_2 PF13465.6 PIK53156.1 - 3.2e-33 112.7 83.0 3.9e-06 27.0 5.2 9.4 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK53156.1 - 1.4e-14 53.6 82.7 0.00055 20.2 4.4 8.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK53156.1 - 4.3e-14 52.0 74.6 0.0021 18.8 3.1 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK53156.1 - 2.5e-09 37.2 56.9 0.00022 21.4 5.0 8.2 6 2 2 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK53156.1 - 0.00016 21.9 3.2 0.00016 21.9 3.2 7.3 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK53156.1 - 0.015 15.0 0.6 0.015 15.0 0.6 4.9 6 0 0 6 6 6 0 zinc-finger C2H2-type Mito_carr PF00153.27 PIK53157.1 - 1.7e-56 188.2 2.0 7.1e-25 86.8 0.0 3.3 2 2 1 3 3 3 3 Mitochondrial carrier protein VanW PF04294.13 PIK53157.1 - 0.085 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 VanW like protein AIG1 PF04548.16 PIK53158.1 - 2.9e-74 249.0 17.3 2.2e-44 151.4 4.5 3.1 2 0 0 2 2 2 2 AIG1 family Hint PF01079.20 PIK53158.1 - 1.9e-31 109.3 0.0 6.8e-31 107.4 0.0 1.9 1 0 0 1 1 1 1 Hint module MMR_HSR1 PF01926.23 PIK53158.1 - 1.4e-18 67.1 9.4 9.4e-10 38.6 0.7 3.6 3 1 0 3 3 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK53158.1 - 3.9e-09 36.6 14.8 4.3e-05 23.5 0.2 5.0 5 2 0 5 5 5 2 RsgA GTPase CARD PF00619.21 PIK53158.1 - 1.2e-08 34.8 1.4 1.2e-08 34.8 1.4 3.2 4 0 0 4 4 3 1 Caspase recruitment domain Septin PF00735.18 PIK53158.1 - 2.8e-08 33.4 13.5 0.00023 20.6 0.5 4.5 3 1 1 4 4 4 2 Septin FeoB_N PF02421.18 PIK53158.1 - 1.5e-05 24.6 1.8 0.0082 15.7 0.1 2.7 2 0 0 2 2 2 2 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.18 PIK53158.1 - 0.00037 19.9 0.0 0.11 11.8 0.0 3.0 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 PIK53158.1 - 0.0007 19.3 0.5 0.72 9.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 PIK53158.1 - 0.00083 19.4 0.7 0.00083 19.4 0.7 6.4 7 3 3 10 10 6 3 Dynamin family AAA_7 PF12775.7 PIK53158.1 - 0.00094 18.7 0.7 0.85 9.1 0.1 2.9 2 0 0 2 2 2 2 P-loop containing dynein motor region Ras PF00071.22 PIK53158.1 - 0.001 18.7 2.4 0.71 9.5 0.3 3.0 2 0 0 2 2 2 2 Ras family Arf PF00025.21 PIK53158.1 - 0.0014 18.1 2.1 0.08 12.4 0.1 3.8 3 0 0 3 3 3 1 ADP-ribosylation factor family HisKA_2 PF07568.12 PIK53158.1 - 0.0047 17.0 4.6 0.01 15.9 0.1 3.9 4 0 0 4 4 2 1 Histidine kinase T2SSE PF00437.20 PIK53158.1 - 0.015 14.4 0.2 0.53 9.3 0.1 2.8 2 1 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 PIK53158.1 - 0.041 14.4 0.1 0.041 14.4 0.1 5.5 5 1 0 5 5 4 0 ABC transporter Methyltr_RsmB-F PF01189.17 PIK53158.1 - 0.13 11.9 9.3 0.26 10.9 0.1 4.1 5 0 0 5 5 5 0 16S rRNA methyltransferase RsmB/F Hpr_kinase_C PF07475.12 PIK53158.1 - 0.19 11.2 5.0 8.1 5.9 0.0 3.8 4 0 0 4 4 4 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 PIK53158.1 - 0.21 11.8 5.5 5 7.4 0.5 4.0 3 1 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 PIK53158.1 - 0.24 11.1 3.9 2.9 7.7 0.2 3.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CcmD PF04995.14 PIK53158.1 - 0.47 10.6 1.2 1.3 9.2 1.2 1.7 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) AAA_16 PF13191.6 PIK53158.1 - 0.58 10.5 3.2 68 3.8 0.1 4.2 4 0 0 4 4 4 0 AAA ATPase domain BNIP2 PF12496.8 PIK53158.1 - 1 9.8 6.1 0.57 10.6 0.7 2.8 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 AAA_24 PF13479.6 PIK53158.1 - 4 7.1 10.9 13 5.5 0.0 4.2 3 1 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 PIK53158.1 - 7.7 6.0 19.5 7.8 6.0 4.8 5.4 3 2 0 3 3 3 0 Elongation factor Tu GTP binding domain Hint PF01079.20 PIK53159.1 - 3e-31 108.6 0.0 5.3e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Hint module Cactin_mid PF10312.9 PIK53159.1 - 0.0066 16.2 0.5 0.012 15.4 0.5 1.3 1 0 0 1 1 1 1 Conserved mid region of cactin Intein_splicing PF14890.6 PIK53159.1 - 0.015 15.2 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 Intein splicing domain Ysc84 PF04366.12 PIK53159.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Las17-binding protein actin regulator CcmD PF04995.14 PIK53159.1 - 1 9.5 2.7 2.1 8.5 2.7 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) AIG1 PF04548.16 PIK53160.1 - 4.7e-37 127.4 0.7 5.9e-37 127.1 0.7 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK53160.1 - 9.8e-11 41.7 0.2 1.3e-10 41.4 0.2 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK53160.1 - 1.1e-06 28.8 3.7 0.00021 21.4 0.2 2.9 1 1 1 2 2 2 2 Dynamin family Septin PF00735.18 PIK53160.1 - 3.1e-05 23.4 0.4 6.1e-05 22.4 0.4 1.4 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 PIK53160.1 - 0.0014 18.1 0.8 0.0021 17.5 0.7 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 PIK53160.1 - 0.0015 18.1 0.1 0.0026 17.3 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK53160.1 - 0.0038 17.2 0.0 0.0087 16.0 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 PIK53160.1 - 0.0044 17.6 0.1 0.0054 17.2 0.1 1.2 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.18 PIK53160.1 - 0.0067 15.8 0.1 0.019 14.4 0.1 1.7 2 1 0 2 2 2 1 FtsK/SpoIIIE family IIGP PF05049.13 PIK53160.1 - 0.023 13.8 0.2 0.03 13.4 0.2 1.3 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 PIK53160.1 - 0.031 14.0 0.1 0.067 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 PIK53160.1 - 0.052 12.6 0.3 0.095 11.7 0.1 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein GBP PF02263.19 PIK53160.1 - 0.052 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain GTP_EFTU PF00009.27 PIK53160.1 - 0.055 13.0 0.9 0.45 10.0 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 PIK53160.1 - 0.073 12.8 0.3 0.21 11.4 0.3 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 PIK53160.1 - 0.12 12.7 0.5 0.23 11.7 0.5 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK53160.1 - 0.15 11.5 0.9 0.65 9.5 0.8 1.9 1 1 1 2 2 2 0 P-loop containing dynein motor region AIG1 PF04548.16 PIK53161.1 - 2.7e-44 151.0 3.1 2.7e-44 151.0 3.1 3.1 3 1 0 3 3 3 1 AIG1 family Hint PF01079.20 PIK53161.1 - 8.3e-32 110.4 0.0 1.7e-31 109.4 0.0 1.4 1 0 0 1 1 1 1 Hint module MMR_HSR1 PF01926.23 PIK53161.1 - 4.5e-10 39.6 0.2 1.9e-09 37.6 0.2 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK53161.1 - 0.012 15.7 0.1 0.012 15.7 0.1 5.0 3 3 1 4 4 4 0 Dynamin family Intein_splicing PF14890.6 PIK53161.1 - 0.018 15.0 1.6 0.048 13.6 0.1 2.6 2 1 0 2 2 2 0 Intein splicing domain RsgA_GTPase PF03193.16 PIK53161.1 - 0.029 14.3 0.0 0.029 14.3 0.0 3.2 4 0 0 4 4 4 0 RsgA GTPase AAA_22 PF13401.6 PIK53161.1 - 0.036 14.3 0.1 2.3 8.5 0.0 3.3 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 PIK53161.1 - 0.044 13.1 0.2 0.15 11.4 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 PIK53161.1 - 0.2 12.1 0.1 0.2 12.1 0.1 4.0 3 2 0 3 3 3 0 ABC transporter COesterase PF00135.28 PIK53162.1 - 1.9e-100 337.1 0.0 4.9e-97 325.9 0.0 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK53162.1 - 0.00063 19.7 2.9 0.035 13.9 2.9 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold DDE_Tnp_4 PF13359.6 PIK53163.1 - 2.8e-12 46.6 0.0 4.9e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-C4 PF00105.18 PIK53164.1 - 9.4e-31 106.1 14.2 1.3e-30 105.7 14.2 1.2 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) zf-RRPl_C4 PF17026.5 PIK53164.1 - 0.27 11.3 6.8 0.36 11.0 6.8 1.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Hormone_recep PF00104.30 PIK53165.1 - 6.1e-18 65.1 2.5 1.6e-17 63.8 2.5 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DPM2 PF07297.12 PIK53166.1 - 4.8e-22 78.1 6.0 5.2e-22 77.9 6.0 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 PIK53166.1 - 0.17 11.8 3.2 0.18 11.8 3.2 1.1 1 0 0 1 1 1 0 PIG-P DUF4647 PF15504.6 PIK53168.1 - 2.7e-16 59.8 4.9 9e-15 54.7 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4647) Yos9_DD PF17880.1 PIK53168.1 - 0.033 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Yos9 dimerzation domain EF-hand_7 PF13499.6 PIK53169.1 - 3.5e-11 43.4 0.3 6.3e-11 42.6 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK53169.1 - 5.3e-11 41.3 3.8 3.5e-07 29.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK53169.1 - 1.7e-07 30.6 1.2 0.0099 15.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 PIK53169.1 - 2.6e-06 27.2 0.8 6.9e-06 25.8 0.3 1.9 1 1 1 2 2 2 1 EF-hand domain pair Ribosomal_L29 PF00831.23 PIK53169.1 - 0.0027 17.6 0.4 0.019 14.9 0.4 2.1 1 1 0 1 1 1 1 Ribosomal L29 protein EF-hand_5 PF13202.6 PIK53169.1 - 0.0064 15.9 3.7 0.048 13.2 0.0 3.1 3 0 0 3 3 3 1 EF hand MMU163 PF17119.5 PIK53169.1 - 0.036 13.2 0.1 0.046 12.9 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Caleosin PF05042.13 PIK53169.1 - 0.15 12.0 0.2 0.38 10.7 0.2 1.7 1 1 1 2 2 2 0 Caleosin related protein PIP49_C PF12260.8 PIK53170.1 - 1.9e-28 99.4 0.0 2.9e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 PIK53170.1 - 4.9e-09 36.2 0.6 8.9e-09 35.4 0.6 1.4 1 0 0 1 1 1 1 N-term cysteine-rich ER, FAM69 SNF PF00209.18 PIK53171.1 - 9.9e-91 305.0 12.6 1.1e-90 304.8 12.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF2484 PF10658.9 PIK53171.1 - 0.049 13.9 0.3 0.049 13.9 0.3 3.2 3 2 1 4 4 4 0 Protein of unknown function (DUF2484) Peptidase_M15_4 PF13539.6 PIK53171.1 - 0.11 13.0 0.8 1 9.9 0.1 2.6 3 0 0 3 3 3 0 D-alanyl-D-alanine carboxypeptidase Pam17 PF08566.10 PIK53171.1 - 0.17 11.7 0.4 0.94 9.3 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 SNF PF00209.18 PIK53172.1 - 5.8e-159 530.1 31.0 1.1e-157 525.9 31.0 1.9 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family Peptidase_M15_4 PF13539.6 PIK53172.1 - 0.044 14.3 0.1 0.53 10.8 0.0 2.3 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Exo_endo_phos PF03372.23 PIK53173.1 - 0.12 11.9 4.4 0.3 10.6 4.5 1.8 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family REV PF00424.18 PIK53173.1 - 0.22 11.5 1.8 7.4 6.7 0.2 2.7 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Keratin_2_head PF16208.5 PIK53173.1 - 4.8 7.3 41.0 7 6.8 41.0 1.2 1 0 0 1 1 1 0 Keratin type II head CUT PF02376.15 PIK53174.1 - 7.6e-32 109.3 0.2 1.1e-31 108.8 0.2 1.3 1 0 0 1 1 1 1 CUT domain FAD-oxidase_C PF02913.19 PIK53175.1 - 0.023 14.3 0.5 0.037 13.7 0.5 1.3 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain YabA PF06156.13 PIK53175.1 - 0.19 12.4 2.7 0.59 10.8 2.7 1.8 1 0 0 1 1 1 0 Initiation control protein YabA Nucleotid_trans PF03407.16 PIK53176.1 - 7.6e-21 75.1 1.2 1.3e-20 74.3 1.2 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase NACHT PF05729.12 PIK53178.1 - 3.7e-13 49.7 0.0 9.1e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain C1-set PF07654.15 PIK53178.1 - 2.3e-06 27.9 4.6 0.042 14.2 0.3 3.0 2 0 0 2 2 2 2 Immunoglobulin C1-set domain AAA_25 PF13481.6 PIK53178.1 - 0.00038 20.1 0.0 0.00085 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain C2-set_2 PF08205.12 PIK53178.1 - 0.0021 18.1 4.2 0.019 15.0 0.4 2.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ubiq_cyt_C_chap PF03981.12 PIK53178.1 - 0.028 14.5 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone ig PF00047.25 PIK53178.1 - 0.062 13.5 6.4 0.065 13.4 0.4 3.7 4 1 1 5 5 5 0 Immunoglobulin domain Phostensin PF13914.6 PIK53178.1 - 0.067 13.8 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region Imm25 PF15564.6 PIK53178.1 - 0.16 11.9 1.2 0.27 11.2 0.2 1.9 2 0 0 2 2 2 0 Immunity protein 25 DUF4490 PF14892.6 PIK53179.1 - 0.048 13.7 0.5 0.16 12.1 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4490) I-set PF07679.16 PIK53181.1 - 0.0037 17.3 1.5 0.15 12.2 0.1 3.1 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ubiq_cyt_C_chap PF03981.12 PIK53181.1 - 0.0042 17.2 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DUF2207 PF09972.9 PIK53181.1 - 0.0059 15.4 0.1 0.01 14.7 0.1 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Collectrin PF16959.5 PIK53181.1 - 0.025 14.4 0.6 0.069 12.9 0.6 1.8 1 0 0 1 1 1 0 Renal amino acid transporter TMEM154 PF15102.6 PIK53181.1 - 0.1 12.5 2.4 0.21 11.5 2.4 1.5 1 0 0 1 1 1 0 TMEM154 protein family FeoB_associated PF12669.7 PIK53181.1 - 0.16 12.4 0.2 0.38 11.2 0.2 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Aldo_ket_red PF00248.21 PIK53182.1 - 2.7e-26 92.5 0.0 3.3e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 PIK53183.1 - 1e-33 116.8 0.1 6e-18 65.1 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family Aldo_ket_red PF00248.21 PIK53184.1 - 1.8e-49 168.6 0.0 2.3e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family CCDC53 PF10152.9 PIK53185.1 - 3.9e-42 144.3 0.1 8.1e-42 143.2 0.1 1.5 1 1 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF3671 PF12420.8 PIK53185.1 - 0.025 14.6 0.2 0.041 14.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function OAS1_C PF10421.9 PIK53188.1 - 2.3e-12 46.8 0.0 3.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus SMODS PF18144.1 PIK53188.1 - 5e-07 30.0 0.0 1.2e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 PIK53188.1 - 0.0028 17.9 0.0 0.0073 16.6 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Vps62 PF06101.11 PIK53189.1 - 3.9e-13 48.6 0.0 2.9e-10 39.1 0.0 2.1 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 62 ETX_MTX2 PF03318.13 PIK53189.1 - 7.8e-08 32.4 3.2 1.4e-07 31.6 3.2 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK53189.1 - 5.7e-05 22.5 1.2 9.1e-05 21.8 1.2 1.2 1 0 0 1 1 1 1 Aerolysin toxin RRP14 PF15459.6 PIK53191.1 - 0.019 15.5 0.1 0.043 14.4 0.1 1.5 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 RVT_1 PF00078.27 PIK53193.1 - 1.5e-07 31.2 0.0 2.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK53193.1 - 0.00019 21.7 0.1 0.001 19.4 0.0 2.2 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK53193.1 - 0.00047 20.1 4.3 0.00047 20.1 4.3 2.5 2 0 0 2 2 2 1 Zinc knuckle Peptidase_A2E PF12382.8 PIK53193.1 - 0.008 16.2 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon peptidase gag-asp_proteas PF13975.6 PIK53193.1 - 0.023 15.3 0.0 0.063 13.9 0.0 1.9 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK53193.1 - 0.14 12.8 0.0 0.35 11.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zinc-ribbons_6 PF07191.12 PIK53193.1 - 0.19 11.7 6.1 0.47 10.5 6.1 1.6 1 0 0 1 1 1 0 zinc-ribbons ATP-synt_ab PF00006.25 PIK53196.1 - 7.9e-18 64.9 0.0 1.8e-17 63.8 0.0 1.6 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ig PF00047.25 PIK53198.1 - 8.8e-06 25.8 1.4 0.035 14.3 1.5 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK53198.1 - 0.00018 22.1 0.9 0.34 11.5 0.6 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK53198.1 - 0.0028 18.0 0.4 0.029 14.7 0.7 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK53198.1 - 0.0066 16.5 0.6 0.016 15.2 0.6 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK53199.1 - 6.5e-06 26.2 0.0 2.6e-05 24.2 0.0 2.0 1 1 0 1 1 1 1 NACHT domain MLANA PF14991.6 PIK53199.1 - 0.092 13.0 0.1 0.092 13.0 0.1 3.0 3 0 0 3 3 3 0 Protein melan-A OAD_gamma PF04277.13 PIK53199.1 - 1.5 9.5 3.8 2.1 9.0 0.0 3.0 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain RVT_1 PF00078.27 PIK53201.1 - 1.4e-21 77.1 0.0 1.7e-21 76.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HeH PF12949.7 PIK53201.1 - 0.027 14.2 0.2 0.049 13.4 0.2 1.4 1 0 0 1 1 1 0 HeH/LEM domain Integrase_H2C2 PF17921.1 PIK53202.1 - 3.2e-19 68.8 0.1 5.8e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK53202.1 - 1.6e-18 67.0 0.0 2.9e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK53202.1 - 4.7e-07 29.5 0.0 1.5e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 SCAN domain zf-H2C2 PF09337.10 PIK53202.1 - 3.4e-05 24.0 0.0 7.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK53202.1 - 0.00084 19.1 0.0 0.0023 17.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain NEAT PF05031.12 PIK53202.1 - 0.092 13.4 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 Iron Transport-associated domain V-set PF07686.17 PIK53203.1 - 3.4e-09 36.8 0.5 1.7e-08 34.6 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK53203.1 - 1.6e-08 34.5 0.0 1.8e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53203.1 - 4.8e-07 30.3 0.6 0.00089 19.8 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK53203.1 - 8e-06 26.0 1.2 0.064 13.4 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain REJ PF02010.15 PIK53203.1 - 0.00095 18.1 0.1 0.00095 18.1 0.1 1.1 1 0 0 1 1 1 1 REJ domain C1-set PF07654.15 PIK53203.1 - 0.0055 17.0 1.4 0.012 15.9 0.6 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK53203.1 - 0.017 15.2 0.1 0.042 13.9 0.1 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK53204.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.9 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.17 PIK53204.1 - 0.056 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Peptidase_C1 PF00112.23 PIK53205.1 - 3.4e-48 164.6 3.9 4.6e-48 164.2 3.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK53205.1 - 7.3e-10 39.1 2.6 7.3e-10 39.1 2.6 1.8 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 PIK53205.1 - 0.0013 17.6 0.1 0.07 11.9 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DUF1202 PF06717.11 PIK53205.1 - 0.042 13.3 0.2 0.081 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) RVT_1 PF00078.27 PIK53206.1 - 7.2e-20 71.4 0.0 1.1e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ephrin_rec_like PF07699.13 PIK53206.1 - 3.2e-12 46.0 9.0 3.2e-12 46.0 9.0 2.2 1 1 1 2 2 2 2 Putative ephrin-receptor like RT_RNaseH_2 PF17919.1 PIK53206.1 - 1.2e-10 41.3 0.0 2.5e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TNFR_c6 PF00020.18 PIK53206.1 - 0.19 12.2 5.6 1.1 9.8 0.6 3.1 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region ACC_central PF08326.12 PIK53207.1 - 5.2e-178 593.6 6.3 6.8e-178 593.2 6.3 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 PIK53207.1 - 2e-164 547.9 0.0 3e-164 547.3 0.0 1.3 1 0 0 1 1 1 1 Carboxyl transferase domain DUF3767 PF12597.8 PIK53207.1 - 0.13 12.0 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) Peptidase_M17 PF00883.21 PIK53208.1 - 1.9e-98 329.6 0.0 2.4e-98 329.3 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 PIK53208.1 - 1.2e-26 93.4 0.0 3.2e-26 92.0 0.0 1.8 1 0 0 1 1 1 1 M17 aminopeptidase N-terminal domain 2 Tubulin PF00091.25 PIK53209.1 - 1.3e-68 231.1 0.0 2.1e-68 230.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK53209.1 - 6.8e-43 145.8 0.1 1e-42 145.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 PIK53209.1 - 2.1e-05 24.8 0.1 5.9e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 PIK53209.1 - 0.0057 16.3 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 PIK53209.1 - 0.0089 15.2 0.0 0.02 14.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin like DUF2935 PF11155.8 PIK53210.1 - 0.0012 19.2 17.2 0.066 13.6 13.0 3.7 2 1 1 3 3 3 1 Domain of unknown function (DUF2935) EcsC PF12787.7 PIK53210.1 - 0.069 12.8 0.5 0.069 12.8 0.5 2.5 1 1 0 2 2 2 0 EcsC protein family DUF948 PF06103.11 PIK53210.1 - 0.39 11.0 16.5 0.93 9.8 4.8 4.0 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DWNN PF08783.11 PIK53210.1 - 1.4 9.3 5.7 1.5 9.1 0.8 2.6 2 0 0 2 2 2 0 DWNN domain YtxH PF12732.7 PIK53210.1 - 1.4 9.5 13.2 12 6.5 0.8 3.5 1 1 1 2 2 2 0 YtxH-like protein Baculo_PEP_C PF04513.12 PIK53210.1 - 1.9 8.5 19.2 0.38 10.8 2.2 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1319 PF07028.11 PIK53210.1 - 2.9 8.1 31.4 1.1 9.6 3.8 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1319) ZnuA PF01297.17 PIK53210.1 - 4.2 6.7 8.4 4.5 6.6 1.4 2.5 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic TSNAXIP1_N PF15739.5 PIK53210.1 - 5 7.6 37.8 1.8 9.0 0.5 4.0 1 1 3 4 4 4 0 Translin-associated factor X-interacting N-terminus CVNH PF08881.10 PIK53211.1 - 0.11 13.2 1.0 2.1 9.1 0.2 2.7 1 1 2 3 3 3 0 CVNH domain FAM184 PF15665.5 PIK53211.1 - 1.8 8.3 59.3 9.4 5.9 12.5 3.2 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B Muted PF14942.6 PIK53211.1 - 4 7.8 48.3 4.6 7.6 22.9 3.1 1 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein HOOK PF05622.12 PIK53212.1 - 0.00053 18.3 30.8 0.00077 17.7 30.8 1.2 1 0 0 1 1 1 1 HOOK protein DUF4485 PF14846.6 PIK53212.1 - 0.00055 19.9 1.3 0.0017 18.4 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4485) DLP_helical PF18709.1 PIK53212.1 - 0.0043 16.3 19.9 0.0062 15.8 19.9 1.3 1 0 0 1 1 1 1 Dynamin-like helical domain Luteo_PO PF04662.13 PIK53212.1 - 0.038 13.7 0.2 0.078 12.7 0.2 1.5 1 0 0 1 1 1 0 Luteovirus P0 protein PKcGMP_CC PF16808.5 PIK53212.1 - 1.7 8.5 15.9 2.4 8.1 1.3 4.4 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2935 PF11155.8 PIK53212.1 - 3.6 7.9 16.4 4 7.8 2.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Leu_zip PF15294.6 PIK53212.1 - 4.1 6.8 34.7 0.15 11.5 21.0 2.2 1 1 1 2 2 2 0 Leucine zipper CLN3 PF02487.17 PIK53213.1 - 2.8e-23 82.6 1.6 5.2e-23 81.7 1.6 1.4 1 1 0 1 1 1 1 CLN3 protein ABC_membrane PF00664.23 PIK53214.1 - 3.7e-40 138.3 12.3 5.1e-40 137.9 12.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK53214.1 - 1.8e-36 125.7 0.0 3.3e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter MTABC_N PF16185.5 PIK53214.1 - 1.6e-08 34.3 0.7 1.6e-08 34.3 0.7 1.9 2 0 0 2 2 2 1 Mitochondrial ABC-transporter N-terminal five TM region SMC_N PF02463.19 PIK53214.1 - 1.2e-06 28.1 0.1 5.9e-05 22.6 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 PIK53214.1 - 0.00047 20.1 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 PIK53214.1 - 0.00078 19.7 0.1 0.0035 17.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK53214.1 - 0.0015 19.0 0.1 0.0034 17.8 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 PIK53214.1 - 0.0017 18.1 0.0 0.0051 16.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 PIK53214.1 - 0.0074 16.7 0.1 0.078 13.4 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 PIK53214.1 - 0.008 16.0 0.1 0.033 14.0 0.1 1.9 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 PIK53214.1 - 0.0083 15.9 0.1 0.017 14.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK53214.1 - 0.033 13.9 0.0 0.073 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 PIK53214.1 - 0.039 14.4 0.0 0.25 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 PIK53214.1 - 0.042 13.8 0.0 0.43 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 PIK53214.1 - 0.043 13.9 0.0 0.094 12.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 PIK53214.1 - 0.043 13.5 0.2 0.25 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 PIK53214.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 PIK53214.1 - 0.12 12.7 0.2 2.5 8.4 0.2 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Clathrin PF00637.20 PIK53217.1 - 4.4e-28 97.9 2.6 1.7e-27 96.1 2.6 2.1 1 0 0 1 1 1 1 Region in Clathrin and VPS Vps39_1 PF10366.9 PIK53217.1 - 0.00018 21.8 0.2 0.0009 19.5 0.2 2.3 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 PIK53217.1 - 0.0097 16.7 0.6 0.24 12.3 0.1 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53217.1 - 0.019 15.2 0.7 1.2 9.5 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Vps39_2 PF10367.9 PIK53217.1 - 0.022 15.2 0.1 0.088 13.3 0.1 2.1 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 PIK53217.1 - 0.085 12.8 9.6 0.27 11.2 9.6 1.9 1 0 0 1 1 1 0 zinc-RING finger domain Sigma70_ner PF04546.13 PIK53217.1 - 0.15 11.9 7.4 0.36 10.7 7.4 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region Pox_RNA_Pol_19 PF05320.12 PIK53217.1 - 0.15 12.0 6.9 0.37 10.8 6.9 1.6 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Pes-10 PF07149.11 PIK53217.1 - 0.23 10.5 13.3 2.3 7.2 13.3 2.3 2 0 0 2 2 2 0 Pes-10 zf-RING_UBOX PF13445.6 PIK53217.1 - 0.56 10.3 7.3 2.2 8.4 7.3 2.0 1 0 0 1 1 1 0 RING-type zinc-finger Nop14 PF04147.12 PIK53217.1 - 1.2 7.3 10.8 2 6.6 10.8 1.3 1 0 0 1 1 1 0 Nop14-like family zf-C3HC4_2 PF13923.6 PIK53217.1 - 1.9 8.4 7.2 5.8 6.9 7.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK53217.1 - 4.3 7.7 8.4 22 5.4 8.3 2.3 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 PIK53217.1 - 8.4 6.5 10.8 25 5.0 10.8 1.9 1 0 0 1 1 1 0 Zinc-finger Pou PF00157.17 PIK53218.1 - 4.6e-28 97.0 0.1 9.3e-28 96.0 0.1 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 PIK53218.1 - 3.1e-15 55.7 0.8 8.6e-15 54.3 0.8 1.8 1 0 0 1 1 1 1 Homeodomain HOCHOB PF17943.1 PIK53218.1 - 0.049 14.4 0.0 0.091 13.5 0.0 1.4 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox HTH_31 PF13560.6 PIK53218.1 - 0.065 13.6 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Shugoshin_C PF07557.11 PIK53219.1 - 7.3e-07 28.9 4.6 7.3e-07 28.9 4.6 3.1 3 0 0 3 3 3 1 Shugoshin C terminus BBL5 PF07289.11 PIK53221.1 - 1.1e-154 514.5 0.0 1.2e-154 514.3 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 PIK53221.1 - 0.00081 19.5 0.0 0.23 11.7 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 PIK53221.1 - 0.027 14.8 0.0 0.2 12.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial PH domain Voldacs PF03517.13 PIK53221.1 - 0.094 12.8 0.1 13 5.9 0.0 2.5 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling PH_TFIIH PF08567.11 PIK53221.1 - 0.095 13.0 0.0 8.2 6.8 0.0 2.4 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain SH2 PF00017.24 PIK53222.1 - 1.8e-15 56.7 0.1 4e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 SH2 domain BPS PF08947.10 PIK53222.1 - 8.2e-13 48.0 0.2 8.2e-13 48.0 0.2 1.9 2 0 0 2 2 2 1 BPS (Between PH and SH2) PH PF00169.29 PIK53222.1 - 7.8e-10 39.2 0.4 1.8e-09 38.0 0.4 1.7 1 0 0 1 1 1 1 PH domain RA PF00788.23 PIK53222.1 - 3.5e-05 24.4 0.0 8.8e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kindlin_2_N PF18124.1 PIK53222.1 - 0.088 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Kindlin-2 N-terminal domain DUF4551 PF15087.6 PIK53222.1 - 0.094 11.5 2.1 0.14 10.9 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Inositol_P PF00459.25 PIK53223.1 - 6.6e-32 111.1 0.1 8.8e-32 110.7 0.1 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family MPLKIP PF15502.6 PIK53224.1 - 1.5e-07 31.5 0.0 4.4e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 M-phase-specific PLK1-interacting protein Pkinase PF00069.25 PIK53225.1 - 1.3e-61 208.3 0.0 3.5e-61 206.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53225.1 - 8.5e-27 94.1 0.0 1.7e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK53225.1 - 9.2e-05 21.5 0.2 9.2e-05 21.5 0.2 2.2 2 1 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 PIK53225.1 - 0.0024 17.2 0.0 0.0051 16.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Merozoite_SPAM PF07133.11 PIK53225.1 - 1.1 9.3 33.5 0.035 14.1 24.7 2.7 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) IPK PF03770.16 PIK53226.1 - 4.4e-48 163.8 0.0 7.5e-48 163.0 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Bcl-2 PF00452.19 PIK53227.1 - 1.8e-15 57.4 0.5 2.7e-15 56.9 0.5 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Cytochrom_C PF00034.21 PIK53228.1 - 3.5e-11 44.1 0.0 5e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 PIK53228.1 - 0.00019 21.6 1.6 0.0009 19.5 1.6 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 PIK53228.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c-550 domain EamA PF00892.20 PIK53229.1 - 2.1e-11 44.1 16.6 1.5e-08 34.9 8.8 2.0 2 0 0 2 2 2 2 EamA-like transporter family DUF3037 PF11236.8 PIK53230.1 - 0.0041 17.5 5.9 0.29 11.6 1.4 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3037) DEAD_assoc PF08494.11 PIK53230.1 - 0.03 14.1 1.9 0.044 13.6 1.9 1.3 1 0 0 1 1 1 0 DEAD/H associated MIP-T3_C PF17749.1 PIK53230.1 - 0.17 11.8 17.0 1.4 8.8 10.5 2.3 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region YtxH PF12732.7 PIK53230.1 - 0.47 11.0 3.2 2.3 8.8 0.9 2.9 2 1 0 2 2 2 0 YtxH-like protein Exonuc_VII_L PF02601.15 PIK53230.1 - 0.5 9.9 9.4 0.67 9.5 9.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit NRBF2 PF08961.10 PIK53230.1 - 0.72 9.4 18.0 0.27 10.8 9.0 2.5 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator APC_N_CC PF16689.5 PIK53230.1 - 0.85 9.7 9.2 0.14 12.3 4.1 2.4 2 1 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain DUF3800 PF12686.7 PIK53230.1 - 1.3 9.7 3.6 13 6.4 3.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF4201 PF13870.6 PIK53230.1 - 1.3 8.7 22.8 2.6 7.7 20.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) FlxA PF14282.6 PIK53230.1 - 2.9 7.9 15.0 0.68 10.0 8.1 2.5 2 1 0 2 2 2 0 FlxA-like protein HALZ PF02183.18 PIK53230.1 - 4.7 7.5 16.3 4.8 7.5 7.5 3.3 3 1 0 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 PIK53230.1 - 4.9 7.4 26.9 2.9 8.1 21.4 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 S-AdoMet_synt_M PF02772.16 PIK53231.1 - 0.13 12.5 0.8 0.17 12.2 0.8 1.1 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain Spectrin_like PF18373.1 PIK53231.1 - 0.24 11.5 0.2 0.24 11.5 0.2 2.2 1 1 0 2 2 2 0 Spectrin like domain NYD-SP28 PF14772.6 PIK53231.1 - 0.33 11.0 19.3 0.036 14.1 12.1 2.0 1 1 1 2 2 2 0 Sperm tail COG2 PF06148.11 PIK53231.1 - 0.42 10.7 7.4 0.44 10.6 5.3 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 PIK53231.1 - 1.2 9.3 11.3 2.1 8.5 1.8 2.8 3 1 0 3 3 3 0 Vps51/Vps67 GCN5L1 PF06320.13 PIK53231.1 - 1.5 9.0 12.1 1.2 9.4 10.1 1.8 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) V_ATPase_I PF01496.19 PIK53231.1 - 4.4 5.1 10.4 4.5 5.1 10.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RuBisCO_large_N PF02788.16 PIK53232.1 - 0.03 14.5 4.3 2.5 8.3 0.2 2.7 3 0 0 3 3 3 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain VraX PF17412.2 PIK53232.1 - 0.22 11.2 0.9 7.9 6.2 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function YpjP PF14005.6 PIK53232.1 - 0.57 10.2 6.2 0.64 10.1 0.1 3.1 2 1 1 3 3 3 0 YpjP-like protein Seryl_tRNA_N PF02403.22 PIK53232.1 - 7.5 6.8 10.6 0.066 13.4 1.0 2.5 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain SAB PF04382.13 PIK53233.1 - 0.019 15.0 1.0 3 8.0 0.1 3.1 2 0 0 2 2 2 0 SAB domain HTH_6 PF01418.17 PIK53233.1 - 0.44 10.6 3.8 12 6.0 0.3 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family SSXRD PF09514.10 PIK53233.1 - 0.69 9.5 3.7 23 4.7 0.3 2.8 2 0 0 2 2 2 0 SSXRD motif MHC2-interact PF09307.10 PIK53233.1 - 1.4 8.9 5.1 28 4.8 0.4 3.0 2 0 0 2 2 2 0 CLIP, MHC2 interacting Aldo_ket_red PF00248.21 PIK53234.1 - 3.1e-41 141.5 0.0 1.7e-40 139.1 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Rif1_N PF12231.8 PIK53235.1 - 1.2e-53 182.5 6.8 1.2e-53 182.5 6.8 1.8 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal TRC8_N PF13705.6 PIK53235.1 - 0.0018 17.2 5.2 0.0052 15.8 5.2 1.8 1 1 0 1 1 1 1 TRC8 N-terminal domain PH_3 PF14593.6 PIK53235.1 - 0.022 14.9 1.3 0.043 13.9 0.1 2.1 2 0 0 2 2 2 0 PH domain Aa_trans PF01490.18 PIK53238.1 - 2.2e-63 214.4 31.2 2.5e-63 214.2 31.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TMEM191C PF15194.6 PIK53238.1 - 0.038 14.2 0.3 0.12 12.5 0.3 1.9 1 1 0 1 1 1 0 TMEM191C family Oxidored_q5_N PF01059.17 PIK53238.1 - 0.34 11.0 8.6 5.3 7.2 1.5 2.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus YlaC PF10777.9 PIK53238.1 - 2.5 7.9 7.8 0.35 10.7 2.4 2.2 1 1 1 2 2 2 0 Inner membrane protein YlaC TMEM174 PF15029.6 PIK53238.1 - 8.4 6.0 8.0 1.5 8.5 1.3 2.2 2 0 0 2 2 2 0 Transmembrane protein 174 C2-set_2 PF08205.12 PIK53239.1 - 0.013 15.6 0.1 1.2 9.3 0.0 2.9 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK53239.1 - 0.023 14.8 0.3 0.3 11.3 0.1 2.8 1 1 1 2 2 2 0 Immunoglobulin V-set domain Myco_arth_vir_N PF09610.10 PIK53239.1 - 0.13 12.4 0.3 0.46 10.6 0.3 2.0 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) TMEM154 PF15102.6 PIK53239.1 - 7.9 6.4 8.1 0.36 10.7 0.8 2.6 3 1 1 4 4 4 0 TMEM154 protein family Pkinase_Tyr PF07714.17 PIK53240.1 - 1.4e-60 204.8 0.0 5e-60 203.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK53240.1 - 4.8e-25 88.4 0.0 9.8e-25 87.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK53240.1 - 0.031 13.6 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Citrate_synt PF00285.21 PIK53241.1 - 3.5e-62 210.6 0.0 9.5e-40 136.8 0.0 2.1 2 0 0 2 2 2 2 Citrate synthase, C-terminal domain Cpn10 PF00166.21 PIK53242.1 - 9.2e-29 99.4 0.0 1e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 PIK53243.1 - 1e-76 258.6 14.0 9.2e-76 255.4 14.4 2.2 1 1 1 2 2 2 1 TCP-1/cpn60 chaperonin family HEAT PF02985.22 PIK53244.1 - 1.2e-12 46.9 3.4 1.3 9.4 0.1 7.9 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 PIK53244.1 - 3.3e-11 43.4 0.1 0.27 11.8 0.0 6.2 6 0 0 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 PIK53244.1 - 1.5e-08 34.9 0.1 0.026 14.9 0.0 6.3 5 1 1 7 7 7 2 HEAT repeats Cnd1 PF12717.7 PIK53244.1 - 3e-06 27.4 4.8 0.82 9.7 0.1 5.2 3 2 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 PIK53244.1 - 0.00016 21.6 0.5 0.1 12.5 0.0 4.6 3 1 1 5 5 5 1 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 PIK53244.1 - 0.0011 17.7 1.0 25 3.2 0.1 2.6 1 1 0 1 1 1 0 Adaptin N terminal region NUC173 PF08161.12 PIK53244.1 - 0.0018 18.0 0.1 0.93 9.1 0.0 4.0 1 1 3 4 4 4 1 NUC173 domain MMS19_C PF12460.8 PIK53244.1 - 0.0021 17.3 0.0 4.2 6.4 0.0 4.3 1 1 1 4 4 4 1 RNAPII transcription regulator C-terminal DNA_pol_phi PF04931.13 PIK53244.1 - 0.0047 15.1 0.0 1.3 7.0 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase phi Vac14_Fab1_bd PF12755.7 PIK53244.1 - 0.0078 16.8 0.2 3.4 8.3 0.0 3.9 5 0 0 5 5 4 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK53244.1 - 0.0087 15.6 0.1 1.9 8.0 0.0 3.4 3 0 0 3 3 3 1 CLASP N terminal UME PF08064.13 PIK53244.1 - 0.011 15.6 0.2 7.5 6.5 0.0 4.7 3 1 2 5 5 5 0 UME (NUC010) domain Arm PF00514.23 PIK53244.1 - 0.012 15.6 0.8 18 5.6 0.0 5.1 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 PIK53244.1 - 0.043 13.8 0.0 0.25 11.3 0.0 2.3 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central DRIM PF07539.12 PIK53244.1 - 0.063 11.6 0.0 5.4 5.2 0.0 2.7 1 1 0 2 2 2 0 Down-regulated in metastasis TAF6_C PF07571.13 PIK53244.1 - 0.07 13.5 0.0 0.62 10.4 0.0 2.7 1 1 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain DUF1428 PF07237.11 PIK53244.1 - 0.095 13.0 0.1 0.78 10.0 0.1 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1428) SF3b1 PF08920.10 PIK53245.1 - 1.5e-43 148.1 43.6 9.9e-42 142.2 6.0 5.6 2 1 2 4 4 4 2 Splicing factor 3B subunit 1 Polyketide_cyc PF03364.20 PIK53246.1 - 2.3e-24 86.0 0.0 3e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF1857 PF08982.11 PIK53246.1 - 0.014 15.3 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1857) EF-hand_1 PF00036.32 PIK53247.1 - 2.7e-17 60.9 0.0 5.1e-05 22.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK53247.1 - 3.1e-14 51.6 0.1 5.9e-06 25.8 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 PIK53247.1 - 4.6e-13 48.8 0.1 2.6e-09 36.8 0.0 3.6 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_7 PF13499.6 PIK53247.1 - 3e-11 43.6 0.0 0.0001 22.7 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK53247.1 - 9.1e-09 34.4 0.2 0.0013 18.2 0.0 3.4 3 0 0 3 3 3 2 EF hand DUF2835 PF11197.8 PIK53247.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) Glyco_hydro_79n PF03662.14 PIK53249.1 - 2.2e-18 66.3 0.0 3.4e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 79, N-terminal domain Glyco_hydro_cc PF11790.8 PIK53249.1 - 0.00018 21.1 0.0 0.00031 20.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF5570 PF17731.1 PIK53251.1 - 1.8 8.7 11.4 1.2 9.3 0.6 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5570) TB2_DP1_HVA22 PF03134.19 PIK53252.1 - 4.4e-20 71.4 10.6 7.7e-20 70.6 10.6 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2304 PF10066.9 PIK53252.1 - 0.16 12.2 4.4 0.25 11.6 4.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Myosin_head PF00063.21 PIK53253.1 - 1.1e-38 132.9 0.0 1.1e-38 132.9 0.0 3.0 2 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 PIK53253.1 - 5.6e-33 113.9 71.4 7e-33 113.6 71.4 1.0 1 0 0 1 1 1 1 Myosin tail UPF0242 PF06785.11 PIK53253.1 - 0.012 15.8 56.3 0.02 15.0 30.4 2.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus IQ PF00612.27 PIK53253.1 - 0.093 12.6 4.9 0.83 9.6 0.3 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif Fib_alpha PF08702.10 PIK53253.1 - 0.18 12.0 44.2 0.43 10.8 17.5 3.7 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 PIK53253.1 - 0.25 10.2 61.4 0.18 10.6 43.7 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 PIK53253.1 - 0.27 11.3 73.4 7.7 6.5 18.0 3.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 PIK53253.1 - 0.27 11.3 42.1 0.11 12.5 11.2 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.13 PIK53253.1 - 0.42 11.0 73.6 0.035 14.5 31.5 3.3 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.11 PIK53253.1 - 0.79 8.5 66.0 0.1 11.5 32.7 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein ATG16 PF08614.11 PIK53253.1 - 1.8 8.8 63.2 2.7 8.2 17.0 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) GAS PF13851.6 PIK53253.1 - 2.5 7.4 64.0 0.28 10.5 25.8 3.8 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 PIK53253.1 - 2.8 7.2 51.2 0.063 12.6 10.7 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 PIK53253.1 - 3.2 8.4 44.3 0.035 14.7 11.9 4.3 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Lebercilin PF15619.6 PIK53253.1 - 3.2 7.4 64.4 0.13 11.9 31.7 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease FPP PF05911.11 PIK53253.1 - 4 5.5 64.3 0.11 10.6 26.8 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF5082 PF16888.5 PIK53253.1 - 4.8 7.5 46.0 2.8 8.2 20.3 5.0 1 1 0 2 2 1 0 Domain of unknown function (DUF5082) Macoilin PF09726.9 PIK53253.1 - 5.2 5.5 60.4 0.32 9.5 30.5 2.1 1 1 1 2 2 2 0 Macoilin family ArsR PF09824.9 PIK53253.1 - 5.2 6.6 20.4 0.11 12.0 1.5 4.2 1 1 4 5 5 5 0 ArsR transcriptional regulator Filament PF00038.21 PIK53253.1 - 7.3 6.1 57.0 2.6 7.5 20.1 3.2 1 1 2 3 3 3 0 Intermediate filament protein FH2 PF02181.23 PIK53253.1 - 8.2 5.4 38.6 0.41 9.7 8.7 3.3 1 1 2 3 3 3 0 Formin Homology 2 Domain Myosin_tail_1 PF01576.19 PIK53254.1 - 1.1e-82 278.5 143.7 1.5e-82 278.1 143.7 1.2 1 0 0 1 1 1 1 Myosin tail ERM PF00769.19 PIK53254.1 - 0.00098 19.0 27.6 0.00098 19.0 27.6 5.2 2 2 3 5 5 5 2 Ezrin/radixin/moesin family Laminin_II PF06009.12 PIK53254.1 - 0.0032 17.5 15.2 0.0032 17.5 15.2 7.7 2 1 4 7 7 7 4 Laminin Domain II Filament PF00038.21 PIK53254.1 - 0.0068 16.0 16.9 0.0068 16.0 16.9 6.6 1 1 4 5 5 5 3 Intermediate filament protein DUF1664 PF07889.12 PIK53254.1 - 0.23 11.5 82.5 0.22 11.6 5.1 9.2 1 1 9 10 10 10 0 Protein of unknown function (DUF1664) Sulfatase PF00884.23 PIK53256.1 - 2.5e-35 122.3 0.0 5.2e-35 121.3 0.0 1.4 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK53256.1 - 2e-05 24.4 0.4 0.019 14.6 0.4 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 PIK53256.1 - 0.0028 16.8 0.0 0.012 14.7 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1501) TPR_11 PF13414.6 PIK53257.1 - 1.2e-07 31.3 0.0 0.0033 17.1 0.0 2.8 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 PIK53257.1 - 0.00011 21.9 3.7 0.11 12.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK53257.1 - 0.00015 21.9 0.3 0.049 14.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK53257.1 - 0.00015 22.3 0.0 0.73 10.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK53257.1 - 0.00029 20.7 2.6 0.61 10.3 0.0 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK53257.1 - 0.0022 18.4 0.1 11 6.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK53257.1 - 0.0039 17.3 2.8 2.1 8.8 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat IRS PF02174.17 PIK53258.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 PTB domain (IRS-1 type) Snf7 PF03357.21 PIK53259.1 - 1.7e-37 128.7 18.2 2.1e-37 128.4 18.2 1.1 1 0 0 1 1 1 1 Snf7 DUF1043 PF06295.12 PIK53259.1 - 2 8.4 13.6 0.07 13.1 4.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1043) MitMem_reg PF13012.6 PIK53259.1 - 3 8.3 8.4 76 3.8 8.4 2.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function AP_endonuc_2 PF01261.24 PIK53260.1 - 7.7e-15 54.9 0.1 1e-14 54.5 0.1 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Asp_protease_2 PF13650.6 PIK53261.1 - 7.7e-06 26.5 0.0 1.2e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK53261.1 - 1e-05 26.0 0.0 1.5e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 PIK53262.1 - 7.3e-33 113.9 0.0 1.3e-32 113.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK53262.1 - 5.3e-25 87.4 0.0 1.4e-24 86.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53262.1 - 1.3e-21 76.8 0.0 3e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4371 PF14291.6 PIK53263.1 - 5e-10 39.4 0.0 9.7e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 PIK53263.1 - 1.2e-05 25.0 0.1 3.4e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.15 PIK53263.1 - 0.005 16.7 0.1 0.016 15.0 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Imm30 PF15565.6 PIK53263.1 - 0.019 15.0 0.1 0.2 11.8 0.0 2.6 2 0 0 2 2 2 0 Immunity protein 30 DUF4618 PF15397.6 PIK53263.1 - 0.081 12.3 1.4 0.2 11.1 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Peptidase_A17 PF05380.13 PIK53264.1 - 6.7e-48 162.7 0.0 1.5e-47 161.6 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK53264.1 - 7.3e-10 39.1 0.0 2.4e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53264.1 - 2.8e-09 36.9 0.8 8.6e-09 35.4 0.8 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain BBIP10 PF14777.6 PIK53264.1 - 0.16 11.5 0.2 0.61 9.7 0.1 2.0 2 0 0 2 2 2 0 Cilia BBSome complex subunit 10 DUF5641 PF18701.1 PIK53264.1 - 0.23 11.6 5.4 0.72 10.1 5.4 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5641) CaATP_NAI PF12515.8 PIK53264.1 - 0.24 11.0 4.0 1.1 8.9 0.1 3.4 3 0 0 3 3 3 0 Ca2+-ATPase N terminal autoinhibitory domain HTH_psq PF05225.16 PIK53265.1 - 5e-05 22.9 0.0 8.2e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DUF3475 PF11961.8 PIK53266.1 - 0.082 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3475) DUF4515 PF14988.6 PIK53267.1 - 6.7e-39 133.9 47.9 6.7e-39 133.9 47.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4515) DUF4618 PF15397.6 PIK53267.1 - 0.00026 20.5 44.8 0.00039 19.9 44.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) PI_PP_I PF18363.1 PIK53267.1 - 1.6 8.9 14.6 7.2 6.9 1.3 3.3 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain PHD PF00628.29 PIK53268.1 - 1.1e-06 28.4 5.1 1.9e-06 27.6 2.3 2.7 3 0 0 3 3 3 1 PHD-finger UCH PF00443.29 PIK53268.1 - 0.00019 21.0 0.0 0.00056 19.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase AAA_12 PF13087.6 PIK53269.1 - 3.6e-39 134.5 0.3 1.4e-38 132.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK53269.1 - 1.6e-25 90.4 3.3 9.8e-13 48.5 0.1 3.2 2 1 0 3 3 3 2 AAA domain AAA_19 PF13245.6 PIK53269.1 - 4.6e-09 36.8 0.3 3.7e-07 30.6 0.3 2.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK53269.1 - 2.3e-06 27.5 0.0 0.0033 17.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 PIK53269.1 - 0.00017 21.6 0.0 0.002 18.2 0.0 2.6 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 PIK53269.1 - 0.00021 20.6 2.3 0.00038 19.8 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 PIK53269.1 - 0.0062 16.3 3.2 0.36 10.6 0.0 3.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase PhoH PF02562.16 PIK53269.1 - 0.029 13.8 0.0 0.069 12.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 PIK53269.1 - 0.03 13.9 0.8 1.1 8.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 PIK53269.1 - 0.055 13.9 0.3 0.43 11.0 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK53269.1 - 0.056 13.8 0.0 0.19 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 PIK53269.1 - 0.071 13.1 0.1 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK53269.1 - 0.081 13.2 1.3 1.7 8.9 0.0 3.2 3 1 0 3 3 3 0 AAA domain AAA_12 PF13087.6 PIK53271.1 - 7.7e-38 130.1 0.1 2.7e-37 128.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK53271.1 - 1.1e-18 68.0 1.6 6.9e-17 62.1 1.6 3.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK53271.1 - 9.7e-05 22.2 0.0 0.064 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 PIK53271.1 - 0.00029 21.2 0.1 0.34 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF2087 PF09860.9 PIK53271.1 - 0.007 16.5 0.0 0.034 14.3 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2087) ATPase PF06745.13 PIK53271.1 - 0.049 13.0 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_12 PF13087.6 PIK53272.1 - 1.3e-38 132.6 0.1 3.1e-38 131.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK53272.1 - 8.3e-11 42.2 0.3 3.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK53273.1 - 8.5e-08 32.3 0.0 1.7e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK53273.1 - 5.3e-07 30.1 0.0 1.1e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK53273.1 - 8.4e-05 22.0 0.0 0.00018 20.8 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 PIK53273.1 - 0.00094 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK53273.1 - 0.0023 18.0 0.0 0.0055 16.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 PIK53273.1 - 0.0055 16.2 0.1 0.018 14.5 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein ATPase PF06745.13 PIK53273.1 - 0.019 14.3 0.0 0.69 9.2 0.0 2.3 2 0 0 2 2 2 0 KaiC UvrD-helicase PF00580.21 PIK53273.1 - 0.022 14.3 0.0 0.068 12.7 0.0 1.8 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 PIK53273.1 - 0.053 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK53273.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK53273.1 - 0.069 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 PIK53273.1 - 0.071 13.5 0.0 0.21 12.0 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK53273.1 - 0.074 13.1 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK53273.1 - 0.076 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DEAD PF00270.29 PIK53273.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_18 PF13238.6 PIK53273.1 - 0.16 12.6 0.2 3.1 8.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain ASH PF15780.5 PIK53274.1 - 1.4e-25 89.3 1.8 7.9e-06 26.0 0.0 6.4 5 1 0 5 5 5 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 PIK53274.1 - 5.4e-10 39.4 1.2 0.21 11.8 0.0 5.2 4 0 0 4 4 4 4 Transmembrane protein 131-like MYCBPAP PF14646.6 PIK53274.1 - 0.00024 20.2 0.4 0.0025 16.9 0.0 2.7 3 0 0 3 3 3 1 MYCBP-associated protein family DUF1573 PF07610.11 PIK53274.1 - 0.015 15.3 0.7 16 5.6 0.0 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF1573) Transglut_C PF00927.22 PIK53274.1 - 0.048 13.8 2.9 21 5.3 0.1 4.3 5 0 0 5 5 5 0 Transglutaminase family, C-terminal ig like domain PapD_N PF00345.20 PIK53274.1 - 0.094 12.6 0.2 2.7 7.9 0.0 2.6 2 0 0 2 2 2 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain GCIP PF13324.6 PIK53275.1 - 7.6e-54 183.1 0.1 2.1e-53 181.6 0.1 1.6 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting Chromo PF00385.24 PIK53276.1 - 2.4e-16 59.4 1.0 4.6e-16 58.5 1.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 PIK53276.1 - 9.3e-06 25.7 0.5 1.9e-05 24.7 0.5 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 SRCR PF00530.18 PIK53277.1 - 3.3e-30 104.5 2.8 5.8e-18 65.2 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53277.1 - 1.6e-05 25.3 13.6 4.8e-05 23.8 1.8 3.1 2 2 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53277.1 - 0.037 14.5 0.7 0.79 10.3 0.1 2.4 2 0 0 2 2 2 0 Hepsin, SRCR domain AdoHcyase PF05221.17 PIK53278.1 - 1.5e-117 392.1 0.0 3e-63 213.7 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 PIK53278.1 - 5e-36 124.2 2.4 2e-29 102.8 0.9 2.5 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 PIK53278.1 - 0.0029 17.2 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Oxidored_nitro PF00148.19 PIK53278.1 - 0.0046 15.7 0.1 0.21 10.3 0.0 2.1 2 0 0 2 2 2 1 Nitrogenase component 1 type Oxidoreductase TrkA_N PF02254.18 PIK53278.1 - 0.01 16.1 0.1 0.022 15.0 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 PIK53278.1 - 0.036 13.4 0.0 0.066 12.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 PIK53278.1 - 0.084 13.3 0.1 0.18 12.2 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Urocanase PF01175.18 PIK53278.1 - 0.12 12.0 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain PIF1 PF05970.14 PIK53280.1 - 3.4e-30 105.4 0.8 2.1e-26 93.0 0.0 3.1 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 PIK53280.1 - 4.9e-20 72.1 0.0 1.1e-19 70.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK53280.1 - 1.1e-11 45.3 0.4 3.8e-11 43.5 0.0 2.1 3 0 0 3 3 2 1 AAA domain Herpes_Helicase PF02689.14 PIK53280.1 - 1.8e-05 22.9 0.1 0.0079 14.2 0.0 2.2 2 0 0 2 2 2 2 Helicase AAA_22 PF13401.6 PIK53280.1 - 4.1e-05 23.9 0.0 0.00065 20.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 PIK53280.1 - 0.00019 21.9 0.0 0.00067 20.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 PIK53280.1 - 0.0015 18.4 0.1 0.025 14.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 PIK53280.1 - 0.0075 16.2 0.1 0.058 13.3 0.1 2.2 1 1 0 1 1 1 1 NTPase AFG1_ATPase PF03969.16 PIK53280.1 - 0.011 14.7 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase Viral_helicase1 PF01443.18 PIK53280.1 - 0.017 14.9 0.2 1.4 8.6 0.1 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 PIK53280.1 - 0.034 14.6 0.2 0.22 11.9 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 PIK53280.1 - 0.035 13.3 0.1 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 PIK53280.1 - 0.069 13.6 0.0 0.5 10.8 0.0 2.5 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 PIK53280.1 - 0.081 12.1 0.3 0.23 10.6 0.1 1.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RVP PF00077.20 PIK53282.1 - 0.00059 20.1 0.0 0.0042 17.4 0.0 2.3 2 1 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK53282.1 - 0.00091 19.2 11.3 0.0098 15.9 1.8 2.7 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 PIK53282.1 - 0.0029 18.1 0.0 0.0078 16.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK53282.1 - 0.0032 18.1 0.0 0.015 15.9 0.0 2.1 1 1 1 2 2 2 1 Aspartyl protease zf-CCHC_3 PF13917.6 PIK53282.1 - 1.9 8.5 10.6 1.4 8.9 0.1 2.5 1 1 1 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK53283.1 - 9.1e-34 115.5 0.0 2.4e-33 114.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53283.1 - 9.3e-29 99.8 0.0 3.3e-28 98.1 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK53283.1 - 4.9e-17 61.8 0.2 1.2e-16 60.6 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK53283.1 - 8.3e-15 55.0 0.0 2.3e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK53283.1 - 0.00067 19.8 0.3 0.0017 18.5 0.3 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK53283.1 - 0.00082 19.1 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK53283.1 - 0.073 13.3 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 DDE domain DDE_3 PF13358.6 PIK53283.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease RVT_1 PF00078.27 PIK53287.1 - 4.8e-22 78.6 0.2 9.4e-22 77.6 0.2 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK53287.1 - 9.7e-13 48.6 0.0 1.7e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK53287.1 - 9e-12 45.4 0.0 1.5e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 PIK53287.1 - 0.00013 21.7 0.1 0.00022 21.0 0.1 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF1758 PF05585.12 PIK53287.1 - 0.023 14.5 0.1 0.043 13.6 0.1 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Phage_tail_NK PF16532.5 PIK53287.1 - 0.053 13.1 0.1 3.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Sf6-type phage tail needle knob or tip of some Caudovirales Asp_protease PF09668.10 PIK53287.1 - 0.063 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH PF17917.1 PIK53288.1 - 6.5e-31 106.7 0.2 1.6e-30 105.4 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK53288.1 - 2.7e-26 92.1 0.0 6e-26 91.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK53288.1 - 3.3e-26 91.3 0.2 1.2e-25 89.5 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK53288.1 - 2.8e-07 30.5 0.0 7.5e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain DNA_ligase_A_M PF01068.21 PIK53288.1 - 0.027 14.1 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain rve_3 PF13683.6 PIK53288.1 - 0.11 12.3 0.3 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain V-set PF07686.17 PIK53290.1 - 5.6e-12 45.8 0.7 0.00013 22.1 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK53290.1 - 1.6e-09 37.8 0.9 0.014 15.5 0.1 4.5 4 0 0 4 4 4 3 Immunoglobulin domain NACHT PF05729.12 PIK53290.1 - 1e-08 35.2 0.0 2.2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK53290.1 - 6e-08 33.2 3.3 0.05 14.2 0.0 4.8 4 1 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK53290.1 - 5.8e-06 26.3 0.3 0.024 14.7 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK53290.1 - 8.6e-05 22.8 2.7 1.1 9.6 0.0 4.5 4 1 1 5 5 5 1 Immunoglobulin domain DUF3377 PF11857.8 PIK53290.1 - 0.012 15.5 1.5 0.037 13.9 1.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) RIFIN PF02009.16 PIK53290.1 - 0.11 12.3 0.8 0.21 11.5 0.8 1.3 1 0 0 1 1 1 0 Rifin DP-EP PF08985.11 PIK53290.1 - 0.76 10.0 2.9 4.1 7.6 0.1 3.4 5 0 0 5 5 5 0 DP-EP family Ank_4 PF13637.6 PIK53291.1 - 2.1e-11 44.1 0.3 6.9e-08 32.9 0.0 2.5 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK53291.1 - 2e-09 37.9 0.2 2.8e-09 37.4 0.2 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK53291.1 - 5.5e-09 35.5 2.2 0.0051 17.2 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK53291.1 - 9.2e-09 35.4 1.5 0.00062 20.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK53291.1 - 4.8e-08 33.1 1.4 0.043 14.3 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 PIK53292.1 - 2.1e-20 73.1 0.0 4.6e-10 40.0 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK53292.1 - 2.4e-17 63.1 0.2 2.4e-09 37.5 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ion_trans PF00520.31 PIK53292.1 - 2.8e-15 56.2 27.0 5.4e-15 55.3 27.0 1.5 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.6 PIK53292.1 - 1.9e-10 40.0 0.1 0.00041 20.6 0.0 4.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK53292.1 - 4.7e-09 36.3 0.1 3.3e-08 33.7 0.1 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK53292.1 - 6.7e-09 35.8 0.2 1e-06 28.9 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Nucleos_tra2_C PF07662.13 PIK53292.1 - 0.04 13.7 1.0 0.089 12.6 0.3 1.8 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus Osmo_CC PF08946.10 PIK53292.1 - 1.7 8.9 4.0 0.6 10.4 0.3 2.2 3 0 0 3 3 3 0 Osmosensory transporter coiled coil SRCR PF00530.18 PIK53293.1 - 2.7e-151 493.1 38.0 1.7e-26 92.6 0.1 7.1 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53293.1 - 6.1e-24 84.4 26.1 3.7e-05 24.2 0.1 7.5 7 0 0 7 7 7 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53293.1 - 3.2e-10 40.5 1.3 0.0093 16.5 0.0 6.3 7 0 0 7 7 7 2 Hepsin, SRCR domain DUF1962 PF09227.10 PIK53293.1 - 0.06 13.7 5.5 0.04 14.3 1.4 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1962) PARM PF17061.5 PIK53293.1 - 0.076 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 PARM DUF4690 PF15756.5 PIK53293.1 - 0.11 13.1 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Podoplanin PF05808.11 PIK53293.1 - 0.19 11.8 0.1 0.31 11.1 0.1 1.3 1 0 0 1 1 1 0 Podoplanin DUF2613 PF11021.8 PIK53293.1 - 0.55 10.4 2.3 1.1 9.4 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) SRCR PF00530.18 PIK53294.1 - 6.8e-29 100.3 0.9 2.2e-24 85.9 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53294.1 - 5.5e-05 23.6 0.3 9.9e-05 22.8 0.3 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain RCR PF12273.8 PIK53294.1 - 8.6e-05 23.2 0.2 0.00018 22.1 0.2 1.6 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red HemY_N PF07219.13 PIK53294.1 - 0.013 15.6 1.3 0.023 14.9 1.3 1.3 1 0 0 1 1 1 0 HemY protein N-terminus Peptidase_M56 PF05569.11 PIK53294.1 - 0.017 14.3 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF5305 PF17231.2 PIK53294.1 - 0.026 13.9 0.1 0.051 13.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) LRR19-TM PF15176.6 PIK53294.1 - 0.36 10.9 1.3 0.7 9.9 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain THAP PF05485.12 PIK53295.1 - 9.8e-15 55.3 0.1 1.9e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 THAP domain HTH_44 PF14641.6 PIK53296.1 - 0.09 13.2 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 zf-C4 PF00105.18 PIK53297.1 - 3.1e-32 110.9 17.7 5.4e-32 110.1 17.7 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK53297.1 - 3.9e-23 82.1 0.1 1.1e-22 80.6 0.0 1.8 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Dynein_attach_N PF15867.5 PIK53298.1 - 2.1e-30 104.5 10.2 2.5e-30 104.2 3.5 2.3 2 0 0 2 2 2 2 Dynein attachment factor N-terminus RPAP3_C PF13877.6 PIK53298.1 - 6.3e-17 61.9 0.0 7.5e-16 58.4 0.0 2.5 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 CheY-binding PF09078.11 PIK53298.1 - 0.05 13.7 2.4 0.077 13.1 0.2 2.5 2 0 0 2 2 2 0 CheY binding Chalcone_3 PF16036.5 PIK53298.1 - 0.066 13.3 0.3 0.3 11.2 0.0 2.0 2 0 0 2 2 2 0 Chalcone isomerase-like CDO_I PF05995.12 PIK53299.1 - 0.037 13.4 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I Cupin_2 PF07883.11 PIK53299.1 - 0.078 12.7 0.0 0.21 11.4 0.0 1.7 1 1 0 1 1 1 0 Cupin domain Syndecan PF01034.20 PIK53300.1 - 1.8e-22 79.0 0.1 3.4e-22 78.1 0.1 1.5 1 0 0 1 1 1 1 Syndecan domain SEA PF01390.20 PIK53300.1 - 5.7e-14 52.1 1.1 8.8e-14 51.5 0.2 1.7 1 1 1 2 2 2 1 SEA domain DUF5385 PF17359.2 PIK53300.1 - 0.029 13.9 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) EphA2_TM PF14575.6 PIK53300.1 - 0.075 13.9 0.0 0.18 12.7 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 PIK53300.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) RIFIN PF02009.16 PIK53300.1 - 0.14 12.0 0.9 0.22 11.4 0.9 1.3 1 1 0 1 1 1 0 Rifin Insulin_TMD PF17870.1 PIK53300.1 - 0.17 12.0 2.4 0.6 10.2 2.4 2.0 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment TMEM154 PF15102.6 PIK53300.1 - 0.38 10.6 3.6 1.1 9.1 3.6 1.8 1 1 0 1 1 1 0 TMEM154 protein family RVT_1 PF00078.27 PIK53301.1 - 1.1e-11 44.6 0.1 1.1e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ras PF00071.22 PIK53302.1 - 1.9e-23 82.9 0.0 2.5e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK53302.1 - 4.3e-11 43.1 0.0 7.4e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK53302.1 - 0.00079 19.0 0.0 0.00092 18.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK53302.1 - 0.0036 16.8 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family p450 PF00067.22 PIK53304.1 - 2.4e-113 379.4 0.0 2.7e-113 379.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tma16 PF11176.8 PIK53304.1 - 0.13 12.1 0.9 0.18 11.6 0.2 1.5 2 0 0 2 2 2 0 Translation machinery-associated protein 16 RVT_1 PF00078.27 PIK53305.1 - 4.7e-34 117.8 0.1 1.6e-33 116.1 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Serinc PF03348.15 PIK53306.1 - 1.1e-109 367.2 5.1 1.4e-109 366.9 5.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF4534 PF15049.6 PIK53306.1 - 0.023 14.5 4.5 0.069 12.9 4.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4534) CbtA PF09490.10 PIK53306.1 - 1.9 8.2 6.0 2.2 8.0 2.3 2.3 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) Vault PF01505.18 PIK53309.1 - 1.4e-59 198.0 3.6 1.9e-16 59.9 0.0 5.3 6 0 0 6 6 6 4 Major Vault Protein repeat domain MVP_shoulder PF11978.8 PIK53309.1 - 8e-56 187.2 0.2 1.7e-55 186.1 0.2 1.6 1 0 0 1 1 1 1 Shoulder domain Vault_2 PF17794.1 PIK53309.1 - 2.8e-40 136.5 0.7 4.7e-24 84.5 0.1 2.6 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_3 PF17795.1 PIK53309.1 - 1.6e-38 130.6 1.1 2.5e-34 117.1 0.1 4.0 4 0 0 4 4 4 2 Major Vault Protein Repeat domain Vault_4 PF17796.1 PIK53309.1 - 1.3e-31 108.5 0.8 1.5e-29 101.8 0.0 4.2 5 0 0 5 5 5 1 Major Vault Protein repeat domain Dynein_light PF01221.18 PIK53310.1 - 2.6e-42 143.0 2.0 2.9e-42 142.9 2.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 rve PF00665.26 PIK53312.1 - 1e-13 51.5 0.0 2e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK53312.1 - 0.0035 17.1 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK53313.1 - 6.2e-11 42.2 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK53313.1 - 0.0082 16.2 0.0 0.021 14.9 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 PIK53315.1 - 0.0019 18.2 1.6 0.0033 17.4 1.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK53315.1 - 0.008 16.0 0.6 0.016 15.0 0.6 1.5 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 PIK53317.1 - 9.4e-06 25.8 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 PIK53317.1 - 0.00083 19.3 13.7 0.015 15.4 0.6 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK53317.1 - 0.034 13.8 17.9 0.036 13.8 2.5 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Sif PF06767.11 PIK53317.1 - 0.05 12.6 0.1 0.065 12.2 0.1 1.2 1 0 0 1 1 1 0 Sif protein zf-CCHC_3 PF13917.6 PIK53317.1 - 0.079 12.9 0.1 0.079 12.9 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle gag-asp_proteas PF13975.6 PIK53318.1 - 3.2e-06 27.6 0.0 5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK53318.1 - 0.00016 21.9 0.0 0.00031 21.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK53318.1 - 0.0016 19.1 0.0 0.0022 18.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 PIK53318.1 - 0.099 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH_2 PF17919.1 PIK53319.1 - 1.9e-33 114.5 0.0 3.7e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53319.1 - 3.6e-31 107.6 0.0 7.7e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK53319.1 - 2.3e-12 46.9 0.1 4e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sulfotransfer_3 PF13469.6 PIK53321.1 - 5.3e-08 33.5 0.2 8.2e-07 29.6 0.0 2.7 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK53321.1 - 1.3e-05 24.8 0.0 4.8e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 Sulfotransferase domain DUF1151 PF06625.11 PIK53321.1 - 0.12 12.3 0.5 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) NHL PF01436.21 PIK53322.1 - 3.7e-08 33.0 0.2 3e-07 30.1 0.0 2.3 3 0 0 3 3 3 1 NHL repeat Lactonase PF10282.9 PIK53322.1 - 4.7e-07 29.4 0.1 0.00079 18.8 0.0 1.6 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller DUF1918 PF08940.11 PIK53322.1 - 0.029 14.0 0.0 0.11 12.2 0.0 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1918) SGL PF08450.12 PIK53322.1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region U-box PF04564.15 PIK53323.1 - 0.019 15.1 0.0 0.19 11.9 0.0 2.3 2 1 0 2 2 2 0 U-box domain ADH_zinc_N PF00107.26 PIK53324.1 - 5.1e-25 88.0 0.0 1.4e-24 86.5 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK53324.1 - 2.1e-13 51.5 0.0 5.6e-13 50.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 PIK53324.1 - 4.7e-09 36.1 0.2 2.6e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Ets PF00178.22 PIK53325.1 - 5e-20 71.7 1.3 5e-20 71.7 1.3 2.2 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 PIK53325.1 - 1.8e-05 24.6 1.8 4.5e-05 23.3 1.8 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PAS_3 PF08447.12 PIK53325.1 - 0.077 13.3 1.2 0.18 12.1 0.1 2.1 2 0 0 2 2 2 0 PAS fold Death PF00531.22 PIK53326.1 - 5.7e-10 39.2 1.9 4.4e-08 33.2 0.7 2.3 2 0 0 2 2 2 2 Death domain DED PF01335.21 PIK53326.1 - 6.3e-05 23.2 0.9 0.11 12.8 0.1 2.4 2 0 0 2 2 2 2 Death effector domain DUF4865 PF16157.5 PIK53326.1 - 0.025 14.6 0.1 0.051 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4865) Ets PF00178.22 PIK53327.1 - 6.2e-35 119.5 0.5 1e-34 118.9 0.5 1.3 1 0 0 1 1 1 1 Ets-domain Sox17_18_mid PF12067.8 PIK53327.1 - 0.003 17.6 0.5 0.008 16.2 0.5 1.7 1 0 0 1 1 1 1 Sox 17/18 central domain Lectin_C PF00059.21 PIK53328.1 - 7e-07 30.0 1.8 7.6e-07 29.8 1.8 1.1 1 0 0 1 1 1 1 Lectin C-type domain LRR_8 PF13855.6 PIK53329.1 - 3.2e-15 55.6 9.5 8.2e-12 44.7 0.9 2.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 PIK53329.1 - 2.2e-06 27.4 7.6 0.11 13.1 0.1 4.8 3 2 1 4 4 4 2 Leucine Rich Repeat LRR_4 PF12799.7 PIK53329.1 - 1.4e-05 25.4 8.0 0.0029 18.0 3.3 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53329.1 - 0.00068 19.6 0.2 0.0013 18.7 0.0 1.5 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK53329.1 - 0.052 13.6 8.1 4.3 7.6 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat EGF PF00008.27 PIK53330.1 - 2e-07 31.2 11.1 4.2e-07 30.1 11.1 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK53330.1 - 2e-05 25.0 7.8 2e-05 25.0 7.8 2.5 4 0 0 4 4 3 1 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK53330.1 - 0.034 14.5 5.0 0.06 13.7 5.0 1.3 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_CA PF07645.15 PIK53330.1 - 0.042 14.1 12.0 0.042 14.1 12.0 1.9 2 0 0 2 2 2 0 Calcium-binding EGF domain DUF5305 PF17231.2 PIK53330.1 - 0.058 12.8 0.0 0.072 12.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EGF_2 PF07974.13 PIK53330.1 - 0.091 13.1 13.9 0.17 12.3 13.9 1.4 1 0 0 1 1 1 0 EGF-like domain Pox_EPC_I2-L1 PF12575.8 PIK53330.1 - 0.13 12.5 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 SPT_ssu-like PF11779.8 PIK53330.1 - 0.93 9.2 4.3 0.4 10.3 1.5 1.7 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like EGF_3 PF12947.7 PIK53330.1 - 1.9 8.8 11.0 4.4 7.6 11.0 1.7 1 0 0 1 1 1 0 EGF domain DUF2897 PF11446.8 PIK53330.1 - 1.9 8.4 3.1 3.6 7.5 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) FXa_inhibition PF14670.6 PIK53330.1 - 3.8 7.9 11.3 1.6 9.1 7.9 2.1 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Exo_endo_phos_2 PF14529.6 PIK53332.1 - 1.5e-08 34.5 0.9 2.7e-08 33.7 0.9 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK53332.1 - 0.00012 21.7 0.7 0.0002 20.9 0.7 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF167 PF02594.16 PIK53333.1 - 1.4e-15 57.1 0.0 2.1e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 C2 PF00168.30 PIK53334.1 - 2.6e-26 91.9 0.0 3.7e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 PIK53334.1 - 0.00017 21.2 0.1 0.00042 19.9 0.1 1.7 1 1 0 1 1 1 1 CEP76 C2 domain C2 PF00168.30 PIK53335.1 - 1.5e-24 86.3 0.0 1.7e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 PIK53336.1 - 2.8e-08 34.0 0.0 4.8e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain SEA PF01390.20 PIK53337.1 - 5.1e-07 29.8 0.1 3.7e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 SEA domain EGF_2 PF07974.13 PIK53337.1 - 0.0057 17.0 9.0 0.0095 16.3 9.0 1.3 1 0 0 1 1 1 1 EGF-like domain Aminoglyc_resit PF10706.9 PIK53337.1 - 0.034 13.9 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase TMIE PF16038.5 PIK53337.1 - 0.035 14.0 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 TMIE protein EphA2_TM PF14575.6 PIK53337.1 - 0.05 14.5 0.1 0.084 13.8 0.1 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM190 PF15431.6 PIK53337.1 - 0.078 13.1 0.2 0.14 12.3 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 190 Myc_target_1 PF15179.6 PIK53337.1 - 0.092 12.6 0.3 0.13 12.2 0.3 1.2 1 0 0 1 1 1 0 Myc target protein 1 Ly49 PF08391.10 PIK53337.1 - 0.11 12.9 0.6 0.2 12.0 0.6 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Phage_Gp23 PF10669.9 PIK53337.1 - 0.2 12.0 0.5 0.34 11.2 0.5 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) EGF PF00008.27 PIK53337.1 - 0.21 11.9 4.6 0.43 10.9 4.6 1.4 1 0 0 1 1 1 0 EGF-like domain EGF_3 PF12947.7 PIK53337.1 - 0.92 9.8 9.0 1.5 9.1 9.0 1.3 1 0 0 1 1 1 0 EGF domain EB PF01683.18 PIK53338.1 - 0.033 14.5 11.5 0.017 15.4 9.2 1.9 1 1 1 2 2 2 0 EB module EGF_3 PF12947.7 PIK53338.1 - 2.2 8.5 12.0 16 5.8 0.1 2.6 2 0 0 2 2 2 0 EGF domain EGF_CA PF07645.15 PIK53339.1 - 2.8e-23 81.8 48.1 4.5e-10 39.6 10.2 4.0 3 1 1 4 4 4 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK53339.1 - 1.7e-10 41.0 43.0 0.00026 21.2 9.0 3.7 3 1 0 3 3 3 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK53339.1 - 7.1e-08 32.2 13.7 2.8e-06 27.2 3.7 4.1 3 1 0 3 3 3 2 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK53339.1 - 0.0022 18.1 43.7 0.028 14.6 3.5 4.0 4 1 0 4 4 4 3 EGF domain hEGF PF12661.7 PIK53339.1 - 0.0037 17.9 1.3 0.0037 17.9 1.3 6.1 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK53339.1 - 0.0079 16.2 1.0 0.0079 16.2 1.0 4.3 4 0 0 4 4 4 2 MSP1 EGF domain 1 EGF PF00008.27 PIK53339.1 - 0.018 15.3 2.0 0.018 15.3 2.0 4.9 5 2 0 5 5 5 0 EGF-like domain NIDO PF06119.14 PIK53340.1 - 4.2e-14 53.2 0.9 1.1e-13 51.9 0.2 2.1 2 0 0 2 2 2 1 Nidogen-like EGF_CA PF07645.15 PIK53340.1 - 3e-13 49.7 29.2 2.9e-08 33.8 16.6 4.5 5 1 1 6 6 6 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK53340.1 - 8.6e-11 41.8 16.3 8.6e-11 41.8 16.3 5.5 5 1 0 5 5 5 2 EGF domain FXa_inhibition PF14670.6 PIK53340.1 - 1.2e-05 25.5 6.0 1.2e-05 25.5 6.0 4.9 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site VWD PF00094.25 PIK53340.1 - 0.00011 22.5 0.0 0.00045 20.5 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type D domain cEGF PF12662.7 PIK53340.1 - 0.00025 20.9 2.3 0.00025 20.9 2.3 4.4 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF PF00008.27 PIK53340.1 - 0.0031 17.8 10.7 0.0031 17.8 10.7 5.7 6 2 0 6 6 6 3 EGF-like domain hEGF PF12661.7 PIK53340.1 - 0.19 12.4 26.2 0.97 10.2 6.0 5.4 4 1 0 4 4 4 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK53340.1 - 4.9 7.6 31.8 0.1 13.0 2.5 4.3 3 1 0 3 3 3 0 EGF-like domain Ephrin_rec_like PF07699.13 PIK53342.1 - 5.2e-07 29.3 7.4 5.2e-07 29.3 7.4 5.1 3 2 2 5 5 5 3 Putative ephrin-receptor like CbiM PF01891.16 PIK53342.1 - 2.2 8.1 12.1 0.26 11.1 6.4 2.1 2 0 0 2 2 2 0 Cobalt uptake substrate-specific transmembrane region MIF4G PF02854.19 PIK53343.1 - 4.6e-10 39.5 1.9 9.4e-10 38.5 1.9 1.5 1 1 0 1 1 1 1 MIF4G domain LRR_9 PF14580.6 PIK53344.1 - 1.7e-07 30.9 0.0 0.017 14.6 0.0 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 PIK53344.1 - 0.027 14.9 13.8 0.083 13.3 1.4 3.9 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK53344.1 - 0.94 9.3 7.1 8 6.3 1.6 2.9 1 1 2 3 3 3 0 Leucine rich repeat LRR_6 PF13516.6 PIK53344.1 - 1.8 8.8 9.8 37 4.7 0.2 4.7 4 0 0 4 4 4 0 Leucine Rich repeat Somatomedin_B PF01033.17 PIK53346.1 - 0.0065 16.8 14.7 0.054 13.9 14.7 2.7 1 0 0 1 1 1 1 Somatomedin B domain 7tm_2 PF00002.24 PIK53346.1 - 0.11 11.8 9.8 0.22 10.8 9.8 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) YlbE PF14003.6 PIK53346.1 - 0.14 12.6 0.3 0.37 11.3 0.3 1.6 1 0 0 1 1 1 0 YlbE-like protein rRNA_proc-arch PF13234.6 PIK53347.1 - 5.8e-83 278.9 3.6 1.6e-82 277.5 3.6 1.8 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 PIK53347.1 - 1.9e-46 157.8 0.2 5.9e-46 156.1 0.2 1.9 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 PIK53347.1 - 1.8e-17 63.7 0.0 5.7e-17 62.0 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK53347.1 - 6.9e-07 29.6 0.0 5.7e-06 26.6 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ATPase_2 PF01637.18 PIK53347.1 - 0.0017 18.3 0.8 0.76 9.6 0.0 2.7 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 PIK53347.1 - 0.02 15.2 0.0 0.11 12.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Anthrax-tox_M PF09156.10 PIK53347.1 - 0.055 12.8 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 Anthrax toxin lethal factor, middle domain AAA_19 PF13245.6 PIK53347.1 - 0.15 12.4 0.3 1.1 9.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain TPR_MLP1_2 PF07926.12 PIK53347.1 - 3.4 7.7 7.4 4.7 7.3 0.2 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein LRR_8 PF13855.6 PIK53351.1 - 3.4e-35 119.6 32.9 1.9e-08 34.0 0.3 7.8 2 1 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 PIK53351.1 - 6.5e-28 96.3 40.1 5.9e-05 23.4 0.3 9.3 4 2 5 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK53351.1 - 0.00011 22.3 33.8 3.9 8.4 0.0 12.8 13 3 1 14 14 14 3 Leucine Rich Repeat LRR_5 PF13306.6 PIK53351.1 - 0.013 15.5 0.0 7.7 6.5 0.0 2.9 3 0 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) 7tm_1 PF00001.21 PIK53352.1 - 4.8e-25 88.4 6.4 5.8e-25 88.1 6.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK53352.1 - 8.8e-11 41.7 6.4 1.2e-10 41.2 6.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.8 PIK53352.1 - 0.0098 15.7 12.8 0.013 15.3 12.8 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 SRCR PF00530.18 PIK53353.1 - 1.7e-24 86.2 5.1 2.3e-23 82.6 1.3 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53353.1 - 2.9e-05 24.5 1.9 2.9e-05 24.5 1.9 2.2 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53353.1 - 0.043 14.3 0.3 0.043 14.3 0.3 2.5 2 1 1 3 3 3 0 Hepsin, SRCR domain Ig_4 PF16680.5 PIK53354.1 - 0.0015 18.8 0.0 0.044 14.0 0.0 2.4 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_3 PF13927.6 PIK53354.1 - 0.0074 16.9 1.3 0.034 14.7 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK53354.1 - 0.018 15.5 0.0 0.11 13.0 0.0 2.2 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK53354.1 - 0.038 14.1 0.5 0.51 10.4 0.2 3.0 1 1 1 2 2 2 0 Immunoglobulin I-set domain Y_phosphatase PF00102.27 PIK53355.1 - 5.4e-131 435.3 2.6 7.6e-76 254.8 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK53355.1 - 3.9e-09 36.4 0.2 0.0019 18.0 0.0 3.0 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK53355.1 - 8.5e-09 35.7 2.5 1.5e-08 34.8 0.2 2.8 3 0 0 3 3 3 1 Fibronectin type III domain Y_phosphatase3 PF13350.6 PIK53355.1 - 0.00041 20.4 0.0 0.026 14.5 0.0 2.5 3 0 0 3 3 3 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK53355.1 - 0.00063 19.9 0.2 0.017 15.3 0.0 3.0 2 1 0 2 2 2 1 Inositol hexakisphosphate fn3 PF00041.21 PIK53356.1 - 3.6e-09 36.8 0.3 1.7e-07 31.5 0.1 3.3 3 0 0 3 3 3 1 Fibronectin type III domain Ig_3 PF13927.6 PIK53356.1 - 0.00015 22.3 2.6 0.055 14.1 0.0 4.2 4 0 0 4 4 4 1 Immunoglobulin domain hEGF PF12661.7 PIK53356.1 - 0.00025 21.6 8.9 0.001 19.6 8.9 2.2 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 PIK53356.1 - 0.0021 18.4 15.5 0.0052 17.1 15.5 1.7 1 0 0 1 1 1 1 EGF-like domain Ig_5 PF16681.5 PIK53356.1 - 0.02 15.3 0.0 0.11 12.9 0.0 2.3 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK53356.1 - 0.026 14.6 0.0 0.51 10.5 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin I-set domain EGF PF00008.27 PIK53356.1 - 0.033 14.5 10.8 0.096 13.0 10.8 1.8 1 0 0 1 1 1 0 EGF-like domain V-set PF07686.17 PIK53356.1 - 0.045 13.9 0.0 0.67 10.2 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin V-set domain Laminin_EGF PF00053.24 PIK53356.1 - 0.09 12.9 8.3 0.3 11.3 8.3 1.9 1 0 0 1 1 1 0 Laminin EGF domain Y_phosphatase PF00102.27 PIK53357.1 - 2.4e-25 89.5 0.2 3e-14 53.1 0.0 2.2 1 1 1 2 2 2 2 Protein-tyrosine phosphatase RIC1 PF07064.13 PIK53359.1 - 1.6e-85 286.5 0.1 2.7e-85 285.8 0.1 1.4 1 0 0 1 1 1 1 RIC1 Hydrolase PF00702.26 PIK53360.1 - 4.3e-50 170.9 3.0 7.1e-50 170.2 3.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 PIK53360.1 - 2.8e-47 160.6 4.9 3.6e-47 160.2 2.6 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 PIK53360.1 - 3.1e-29 101.2 0.6 1.6e-12 47.7 0.0 3.7 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 PIK53360.1 - 0.004 16.9 4.4 0.0074 16.1 0.2 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 PIK53360.1 - 0.02 15.3 0.0 0.053 13.9 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 PIK53360.1 - 0.061 13.4 0.0 0.29 11.3 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF3671 PF12420.8 PIK53360.1 - 0.73 9.9 8.4 3.5 7.7 3.2 3.2 3 0 0 3 3 3 0 Protein of unknown function SieB PF14163.6 PIK53361.1 - 0.0013 18.2 0.1 0.002 17.6 0.1 1.3 1 0 0 1 1 1 1 Super-infection exclusion protein B RasGAP PF00616.19 PIK53362.1 - 4e-31 108.4 0.6 3.8e-23 82.3 0.2 3.1 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 PIK53362.1 - 1.4e-19 70.7 1.5 8e-19 68.2 0.5 2.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain MOR2-PAG1_C PF14225.6 PIK53362.1 - 0.014 15.3 0.9 0.26 11.1 0.1 3.0 3 0 0 3 3 3 0 Cell morphogenesis C-terminal CRAL_TRIO PF00650.20 PIK53362.1 - 0.035 13.8 0.6 0.15 11.8 0.6 2.2 1 0 0 1 1 1 0 CRAL/TRIO domain FadR_C PF07840.12 PIK53364.1 - 0.032 14.1 0.2 0.069 13.1 0.2 1.7 1 1 0 1 1 1 0 FadR C-terminal domain TPMT PF05724.11 PIK53365.1 - 7.9e-38 130.3 0.1 1.1e-37 129.8 0.1 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 PIK53365.1 - 3.6e-05 23.6 0.6 0.00019 21.2 0.6 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK53365.1 - 7e-05 23.5 0.0 0.00051 20.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK53365.1 - 8.7e-05 22.4 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK53365.1 - 0.00067 20.3 0.0 0.0026 18.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Homeodomain PF00046.29 PIK53366.1 - 1e-11 44.5 0.0 1.5e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK53366.1 - 0.0027 17.6 0.0 0.0063 16.4 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain LIM PF00412.22 PIK53367.1 - 2.1e-19 69.5 1.9 2.3e-19 69.3 1.9 1.0 1 0 0 1 1 1 1 LIM domain Vps39_2 PF10367.9 PIK53367.1 - 0.033 14.6 1.9 0.91 10.0 0.1 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-FLZ PF04570.14 PIK53367.1 - 0.039 13.4 0.8 0.039 13.4 0.8 1.9 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 zf-FCS PF06467.14 PIK53367.1 - 0.047 13.6 3.5 0.74 9.8 1.4 2.5 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-ACC PF17848.1 PIK53367.1 - 0.1 12.7 5.3 0.26 11.4 0.0 3.0 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain RRM_1 PF00076.22 PIK53368.1 - 4.1e-60 199.5 1.2 1.6e-20 72.7 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK53368.1 - 0.00051 20.1 0.8 6.3 7.0 0.1 4.3 4 0 0 4 4 4 1 RNA recognition motif RRM_occluded PF16842.5 PIK53368.1 - 0.0026 17.6 0.0 6.2 6.8 0.0 3.4 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_3 PF08777.11 PIK53368.1 - 0.0076 16.3 0.5 0.18 11.9 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif PAXIP1_C PF15364.6 PIK53368.1 - 9.6 6.5 11.4 4.3 7.6 4.6 2.8 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein Adeno_PV PF03910.13 PIK53369.1 - 0.14 10.8 7.5 0.2 10.3 7.5 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV TbpB_A PF17484.2 PIK53369.1 - 0.41 11.4 10.7 0.45 11.3 9.9 1.5 1 1 0 1 1 1 0 N-Lobe handle Tf-binding protein B Connexin PF00029.19 PIK53369.1 - 0.85 9.3 4.0 1 9.1 4.0 1.4 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 PIK53369.1 - 1.4 7.8 8.2 1.8 7.5 8.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIF_alpha PF05793.12 PIK53369.1 - 1.6 7.2 28.2 1.9 7.0 28.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 PIK53369.1 - 4.2 5.5 15.1 4.6 5.4 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Ferlin_C PF16165.5 PIK53369.1 - 4.3 7.3 10.2 6.6 6.7 10.2 1.3 1 0 0 1 1 1 0 Ferlin C-terminus ALMT PF11744.8 PIK53369.1 - 5.1 5.8 9.2 5.9 5.6 9.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 PIK53369.1 - 6.5 5.4 9.3 6.4 5.4 9.3 1.1 1 0 0 1 1 1 0 Presenilin zf-RING_2 PF13639.6 PIK53370.1 - 1.4e-13 50.9 10.4 3.3e-13 49.7 10.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 PIK53370.1 - 2.1e-11 43.3 8.5 6e-11 41.9 8.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK53370.1 - 1.9e-08 34.0 10.3 4.7e-08 32.7 10.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK53370.1 - 3.2e-08 33.3 8.9 9.7e-08 31.8 8.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK53370.1 - 1.4e-05 25.2 13.3 1.4e-05 25.2 13.3 2.6 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 PIK53370.1 - 2e-05 24.3 7.1 4.6e-05 23.2 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK53370.1 - 3.5e-05 23.7 8.1 9.2e-05 22.3 8.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Vps39_2 PF10367.9 PIK53370.1 - 0.00011 22.6 0.8 0.00011 22.6 0.8 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-RING_UBOX PF13445.6 PIK53370.1 - 0.00011 22.1 6.8 0.00031 20.7 6.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK53370.1 - 0.00062 19.6 7.0 0.0016 18.2 7.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 PIK53370.1 - 0.64 10.2 8.3 3 8.1 8.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 PIK53370.1 - 2.2 8.0 10.2 2.6 7.7 8.3 2.0 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 PIK53370.1 - 2.8 8.0 11.3 0.91 9.6 7.5 2.2 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger EamA PF00892.20 PIK53371.1 - 5.5e-12 46.0 30.6 2.8e-09 37.3 4.4 2.0 2 0 0 2 2 2 2 EamA-like transporter family EamA PF00892.20 PIK53372.1 - 5e-14 52.6 30.8 8.4e-10 38.9 2.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family zf-HIT PF04438.16 PIK53372.1 - 0.28 11.1 4.8 0.54 10.2 4.8 1.4 1 0 0 1 1 1 0 HIT zinc finger RT_RNaseH_2 PF17919.1 PIK53373.1 - 1.2e-35 121.5 0.0 2.5e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53373.1 - 8.8e-35 119.2 0.0 1.8e-34 118.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK53373.1 - 5.3e-20 71.8 0.3 1.1e-19 70.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK53373.1 - 1.9e-17 63.5 0.0 3.5e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK53373.1 - 4.4e-13 49.1 0.1 1e-12 47.9 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK53373.1 - 0.0088 15.8 0.0 0.033 14.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Dimerisation PF08100.11 PIK53373.1 - 0.025 14.6 0.0 0.35 10.9 0.0 2.6 2 0 0 2 2 2 0 Dimerisation domain gag-asp_proteas PF13975.6 PIK53374.1 - 1.5e-07 31.9 0.0 5.4e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK53374.1 - 4.8e-05 23.9 0.1 9.6e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK53374.1 - 0.0012 19.1 0.0 0.0037 17.6 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-C2HE PF16278.5 PIK53374.1 - 0.052 14.0 0.2 0.052 14.0 0.2 2.9 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4834 PF16118.5 PIK53375.1 - 0.0075 17.2 0.0 0.0075 17.2 0.0 2.9 5 0 0 5 5 5 1 Domain of unknown function (DUF4834) Lectin_C PF00059.21 PIK53376.1 - 6.2e-09 36.6 5.2 1e-08 35.8 5.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK53377.1 - 3.6e-08 34.1 4.8 3.6e-08 34.1 4.8 1.8 2 0 0 2 2 2 1 Lectin C-type domain RE_Eco47II PF09553.10 PIK53377.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Eco47II restriction endonuclease Na_sulph_symp PF00939.19 PIK53378.1 - 2.5e-61 208.2 11.4 2.8e-61 208.0 11.4 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK53378.1 - 2.6e-26 92.6 29.6 2.5e-14 53.2 7.2 1.7 1 1 1 2 2 2 2 Citrate transporter DctM PF06808.12 PIK53378.1 - 0.0072 15.2 7.2 0.011 14.6 7.2 1.4 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component GntP_permease PF02447.16 PIK53378.1 - 0.38 9.4 11.9 0.76 8.4 9.2 2.3 1 1 1 2 2 2 0 GntP family permease Na_sulph_symp PF00939.19 PIK53379.1 - 1.8e-06 27.3 0.0 1.8e-06 27.3 0.0 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK53379.1 - 0.00023 20.5 0.8 0.00026 20.3 0.8 1.1 1 0 0 1 1 1 1 Citrate transporter Na_sulph_symp PF00939.19 PIK53380.1 - 2.3e-13 50.0 2.6 2.8e-13 49.7 2.6 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK53380.1 - 6.2e-08 32.2 0.6 7.5e-08 31.9 0.2 1.3 1 1 0 1 1 1 1 Citrate transporter Dam PF05869.11 PIK53381.1 - 0.079 12.5 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Terminase_3C PF17288.2 PIK53382.1 - 0.0014 19.1 1.7 0.0019 18.6 1.7 1.3 1 1 0 1 1 1 1 Terminase RNAseH like domain BAG PF02179.16 PIK53382.1 - 0.14 12.6 1.3 0.51 10.8 0.2 2.1 2 0 0 2 2 2 0 BAG domain BK_channel_a PF03493.18 PIK53383.1 - 8.5e-26 90.0 0.1 2.8e-25 88.4 0.0 2.0 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 PIK53383.1 - 1.8e-06 27.8 4.8 4e-06 26.7 4.8 1.6 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 PIK53383.1 - 0.00013 22.1 0.0 0.021 15.0 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain Alpha_L_fucos PF01120.17 PIK53384.1 - 1.5e-118 396.3 12.9 1.9e-118 396.0 12.9 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 PIK53384.1 - 9e-27 93.5 0.5 9e-27 93.5 0.5 1.7 2 0 0 2 2 2 1 Alpha-L-fucosidase C-terminal domain GHL6 PF14871.6 PIK53384.1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 VERL PF11386.8 PIK53384.1 - 0.053 13.7 0.3 0.8 9.9 0.1 2.5 2 0 0 2 2 2 0 Vitelline envelope receptor for lysin Laminin_EGF PF00053.24 PIK53385.1 - 3.9e-30 103.7 104.6 5e-11 42.6 13.8 6.3 6 1 0 6 6 6 5 Laminin EGF domain DUF5344 PF17279.2 PIK53385.1 - 0.32 11.6 2.5 0.62 10.7 2.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5344) HIP1_clath_bdg PF16515.5 PIK53385.1 - 4.2 8.0 7.7 13 6.5 0.7 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Aldo_ket_red PF00248.21 PIK53387.1 - 3e-08 33.2 0.1 4.5e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family FMO-like PF00743.19 PIK53388.1 - 4.7e-117 391.6 0.0 5.6e-117 391.3 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK53388.1 - 8.8e-12 44.9 0.0 9.8e-08 31.6 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK53388.1 - 5.1e-08 32.5 0.0 3.6e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK53388.1 - 4.1e-07 29.5 0.5 0.00087 18.5 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 PIK53388.1 - 0.0012 18.9 0.0 0.31 11.0 0.0 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 PIK53388.1 - 0.0045 17.2 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain PilJ_C PF18223.1 PIK53388.1 - 0.017 15.6 0.1 0.11 13.0 0.0 2.1 2 0 0 2 2 2 0 Pili PilJ C-terminal domain DAO PF01266.24 PIK53388.1 - 0.068 12.7 0.1 5.1 6.6 0.0 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 PIK53388.1 - 0.093 12.0 0.1 0.2 10.9 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Citrate_bind PF16114.5 PIK53389.1 - 4.4e-37 127.3 0.1 8e-37 126.4 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 PIK53389.1 - 3.6e-08 33.2 0.1 1e-06 28.5 0.0 2.8 2 1 1 3 3 3 1 ATP-grasp domain Succ_CoA_lig PF13607.6 PIK53389.1 - 5e-06 26.4 0.1 2.1e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Ligase_CoA PF00549.19 PIK53389.1 - 0.00034 20.5 0.0 0.0007 19.4 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase Moricin PF06451.11 PIK53389.1 - 0.096 12.5 0.1 0.29 10.9 0.1 1.8 1 0 0 1 1 1 0 Moricin Citrate_bind PF16114.5 PIK53390.1 - 5.7e-39 133.4 0.0 9e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Ligase_CoA PF00549.19 PIK53390.1 - 3.1e-07 30.3 0.0 6.9e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 PIK53390.1 - 6.9e-06 25.9 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain DUF1726 PF08351.11 PIK53390.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) ApeC PF16977.5 PIK53391.1 - 3.4e-29 102.2 0.0 6.6e-29 101.3 0.0 1.4 1 1 0 1 1 1 1 C-terminal domain of apextrin SSXT PF05030.12 PIK53392.1 - 0.065 12.9 0.2 9.5 5.9 0.0 3.2 2 0 0 2 2 2 0 SSXT protein (N-terminal region) Fungal_TACC PF12709.7 PIK53392.1 - 2 8.9 5.1 0.46 11.0 0.5 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins zf-C2H2_4 PF13894.6 PIK53392.1 - 5 8.2 7.0 16 6.7 1.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger CDC45 PF02724.14 PIK53393.1 - 0.0042 15.5 3.4 0.0044 15.4 3.4 1.1 1 0 0 1 1 1 1 CDC45-like protein BNIP2 PF12496.8 PIK53394.1 - 0.083 13.3 6.0 0.79 10.2 0.6 2.7 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Fungal_TACC PF12709.7 PIK53394.1 - 1.5 9.3 5.3 0.47 10.9 0.5 2.7 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Mod_r PF07200.13 PIK53395.1 - 0.0096 16.0 1.5 0.017 15.2 1.5 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein KfrA_N PF11740.8 PIK53395.1 - 0.2 12.4 1.9 0.37 11.5 1.5 1.7 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term PTH2 PF01981.16 PIK53396.1 - 6.7e-48 161.8 0.0 7.8e-48 161.6 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Rsm22 PF09243.10 PIK53396.1 - 0.016 14.5 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 NatB_MDM20 PF09797.9 PIK53397.1 - 1.2e-94 317.4 1.0 2.6e-94 316.3 1.0 1.6 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit NARP1 PF12569.8 PIK53397.1 - 4.1e-05 22.7 2.0 7.8e-05 21.8 0.1 2.1 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 ANAPC3 PF12895.7 PIK53397.1 - 0.00011 22.3 0.9 0.48 10.7 0.3 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 PIK53397.1 - 0.0013 19.4 0.2 0.17 12.8 0.0 4.1 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK53397.1 - 0.0052 16.8 0.1 0.78 10.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK53397.1 - 0.024 14.5 0.1 0.9 9.5 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK53397.1 - 0.042 14.5 0.0 2.9 8.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK53398.1 - 0.0032 17.5 5.4 0.0058 16.7 5.4 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK53398.1 - 0.0051 17.4 1.0 0.0071 17.0 1.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK53398.1 - 0.011 16.5 0.2 0.024 15.4 0.3 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK53398.1 - 0.014 15.2 3.5 0.014 15.2 3.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK53398.1 - 0.016 15.4 2.9 0.076 13.3 2.7 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK53398.1 - 0.017 15.0 5.4 0.021 14.7 2.8 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK53398.1 - 0.17 11.6 5.0 0.19 11.4 3.5 1.8 2 0 0 2 2 2 0 TPR repeat TPR_19 PF14559.6 PIK53399.1 - 3e-15 56.5 1.5 1.8e-05 25.1 0.6 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK53399.1 - 3.4e-15 54.8 2.4 0.081 13.1 0.0 7.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK53399.1 - 3.3e-10 39.9 2.0 0.039 14.8 0.0 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK53399.1 - 5.7e-10 38.6 2.6 0.73 9.8 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK53399.1 - 1.7e-08 34.9 5.2 0.0057 17.3 0.3 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK53399.1 - 3.4e-08 33.1 0.4 3.7 8.0 0.0 6.9 6 1 1 7 7 7 1 Tetratricopeptide repeat PknG_TPR PF16918.5 PIK53399.1 - 2.1e-06 26.7 0.6 0.00035 19.4 0.3 2.3 2 0 0 2 2 2 2 Protein kinase G tetratricopeptide repeat TPR_21 PF09976.9 PIK53399.1 - 2.4e-06 27.4 2.6 2.3e-05 24.2 1.9 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 PIK53399.1 - 3.5e-06 27.2 8.2 0.026 14.7 0.1 4.4 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 PIK53399.1 - 5.1e-06 26.7 11.6 0.08 13.2 0.7 5.6 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 PIK53399.1 - 6.5e-06 25.6 0.8 0.0059 15.9 0.7 2.7 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK53399.1 - 1e-05 25.8 2.2 38 5.2 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK53399.1 - 0.00021 20.8 3.0 0.0045 16.4 2.9 2.4 2 0 0 2 2 2 1 MalT-like TPR region TPR_11 PF13414.6 PIK53399.1 - 0.0013 18.4 0.3 27 4.5 0.3 4.7 5 0 0 5 5 5 0 TPR repeat ChAPs PF09295.10 PIK53399.1 - 0.0014 17.7 0.4 0.15 11.0 0.0 2.2 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) Cohesin_load PF10345.9 PIK53399.1 - 0.0055 15.2 0.7 0.0095 14.4 0.7 1.3 1 0 0 1 1 1 1 Cohesin loading factor TPR_7 PF13176.6 PIK53399.1 - 0.0062 16.5 3.4 40 4.6 0.1 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK53399.1 - 0.0079 16.5 4.2 0.99 9.9 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 PIK53399.1 - 0.028 14.8 0.8 0.64 10.4 0.4 2.8 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK53399.1 - 0.14 12.0 6.4 41 4.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 PIK53400.1 - 8.4e-19 65.7 1.1 8.8e-07 28.0 0.3 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK53400.1 - 2.4e-16 58.2 1.3 9.7e-06 25.1 0.3 3.6 3 1 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 PIK53400.1 - 1.3e-14 54.4 8.7 1.5e-08 35.0 0.9 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK53400.1 - 4.3e-13 48.1 5.9 0.0012 18.3 0.1 4.2 3 1 1 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK53400.1 - 2.6e-08 33.6 3.6 0.053 13.4 0.6 3.6 3 1 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK53400.1 - 0.00015 22.1 0.6 0.012 15.9 0.2 2.8 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 PIK53400.1 - 0.0012 18.9 0.2 0.38 11.0 0.1 3.0 3 0 0 3 3 3 1 Dockerin type I domain EF-hand_10 PF14788.6 PIK53400.1 - 0.0018 18.1 0.6 1 9.3 0.1 3.2 3 0 0 3 3 3 1 EF hand Caleosin PF05042.13 PIK53400.1 - 0.0045 16.9 0.2 0.039 13.9 0.1 2.0 1 1 1 2 2 2 1 Caleosin related protein DUF2141 PF09912.9 PIK53400.1 - 0.025 14.5 0.5 0.65 9.9 0.1 2.5 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2141) EF-hand_9 PF14658.6 PIK53400.1 - 0.079 13.3 0.0 16 5.9 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain Anillin_N PF16018.5 PIK53401.1 - 2e-17 63.6 2.5 2e-17 63.6 2.5 4.8 4 2 2 6 6 6 1 Anillin N-terminus Anillin PF08174.11 PIK53402.1 - 1.1e-20 74.5 0.5 2.3e-20 73.5 0.5 1.6 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 PIK53402.1 - 9.8e-15 55.0 0.5 3.7e-14 53.1 0.1 2.3 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 PIK53402.1 - 0.021 15.3 3.1 0.025 15.0 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain PDZ PF00595.24 PIK53403.1 - 4.6e-19 68.6 0.9 7.7e-19 67.8 0.9 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK53403.1 - 1.5e-05 24.7 0.2 3.2e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK53403.1 - 0.00071 19.8 0.1 0.0013 19.0 0.1 1.4 1 0 0 1 1 1 1 PDZ domain adh_short PF00106.25 PIK53404.1 - 3.2e-47 160.5 0.9 8.3e-47 159.2 0.1 1.8 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53404.1 - 2.5e-34 118.9 0.0 4e-34 118.2 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK53404.1 - 1.3e-13 51.2 0.1 2.6e-13 50.3 0.1 1.4 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 PIK53404.1 - 8.9e-05 22.0 0.1 0.00014 21.4 0.1 1.3 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 PIK53404.1 - 0.0039 16.9 0.3 0.017 14.9 0.2 2.0 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Herpes_UL3 PF03369.13 PIK53404.1 - 0.026 15.0 0.0 0.046 14.3 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL3 protein EF-hand_1 PF00036.32 PIK53405.1 - 5.2e-14 50.7 0.3 1.4e-06 27.5 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK53405.1 - 7.3e-11 41.1 0.1 3.1e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK53405.1 - 2.1e-08 34.5 0.1 2.2e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK53405.1 - 2.4e-07 30.0 0.1 4.9e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK53405.1 - 0.00018 21.3 0.1 0.33 10.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair Nod_GRP PF07806.11 PIK53405.1 - 0.13 12.1 0.3 0.26 11.1 0.3 1.5 1 0 0 1 1 1 0 Nodule-specific GRP repeat AA_permease_2 PF13520.6 PIK53406.1 - 1.9e-07 30.3 11.8 2.1e-07 30.1 11.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK53406.1 - 0.07 11.7 7.8 0.1 11.1 7.6 1.4 1 1 0 1 1 1 0 Amino acid permease Ldl_recept_b PF00058.17 PIK53407.1 - 9.2e-14 51.7 6.6 4.1e-11 43.2 0.1 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor repeat class B adh_short PF00106.25 PIK53408.1 - 1.7e-39 135.3 0.0 3.1e-39 134.5 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53408.1 - 1.5e-33 116.3 0.0 1.9e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK53408.1 - 4.9e-11 42.9 0.1 7.4e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK53408.1 - 0.0066 15.9 0.2 0.24 10.8 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 7tm_1 PF00001.21 PIK53409.1 - 2.5e-31 109.0 18.8 3.6e-31 108.5 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK53409.1 - 5.1e-08 32.6 11.8 5.1e-08 32.6 11.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK53409.1 - 0.0069 15.8 15.3 0.0093 15.4 15.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Dimer_Tnp_hAT PF05699.14 PIK53410.1 - 1.5e-08 34.3 0.2 2.5e-08 33.6 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region FAM176 PF14851.6 PIK53410.1 - 0.0025 17.5 0.2 0.098 12.3 0.1 2.1 2 0 0 2 2 2 2 FAM176 family Death PF00531.22 PIK53413.1 - 0.00058 20.0 0.0 0.00086 19.4 0.0 1.3 1 0 0 1 1 1 1 Death domain DED PF01335.21 PIK53413.1 - 0.0032 17.8 0.1 0.0057 16.9 0.1 1.6 1 1 0 1 1 1 1 Death effector domain CDC45 PF02724.14 PIK53413.1 - 0.0039 15.6 0.2 0.0046 15.3 0.2 1.0 1 0 0 1 1 1 1 CDC45-like protein PIN_9 PF18477.1 PIK53414.1 - 0.11 12.8 0.2 0.3 11.4 0.2 1.7 1 0 0 1 1 1 0 PIN like domain GED PF02212.18 PIK53414.1 - 0.21 11.8 3.7 45 4.3 0.0 3.9 2 1 0 2 2 2 0 Dynamin GTPase effector domain RHD3 PF05879.12 PIK53415.1 - 3.9e-09 35.2 0.0 3.9e-09 35.2 0.0 3.0 3 0 0 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 PIK53415.1 - 1.9e-06 27.4 2.0 3.3e-06 26.6 0.1 2.4 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 PIK53415.1 - 4.1e-05 23.7 2.9 4.8e-05 23.5 0.4 2.6 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 PIK53415.1 - 0.00011 22.2 0.2 0.00076 19.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Death PF00531.22 PIK53415.1 - 0.0012 19.0 1.4 0.012 15.8 0.0 3.2 3 0 0 3 3 3 1 Death domain DED PF01335.21 PIK53415.1 - 0.79 10.1 8.2 0.28 11.5 0.1 4.0 4 0 0 4 4 4 0 Death effector domain RVT_1 PF00078.27 PIK53418.1 - 1.7e-08 34.3 0.1 2.7e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK53418.1 - 1e-06 28.7 0.0 2.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Y_phosphatase PF00102.27 PIK53419.1 - 4.3e-46 157.4 1.7 1.5e-30 106.5 0.0 2.3 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK53419.1 - 0.00026 20.8 0.0 0.00071 19.4 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK53419.1 - 0.0091 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK53419.1 - 0.033 14.1 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK53420.1 - 3.6e-46 157.6 2.5 4.5e-46 157.3 2.5 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK53420.1 - 0.0003 20.6 0.2 0.00054 19.8 0.2 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK53420.1 - 0.0021 18.1 0.1 0.0061 16.6 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DHHA1 PF02272.19 PIK53422.1 - 2.4e-13 50.7 0.4 2.4e-13 50.7 0.4 2.6 2 0 0 2 2 2 1 DHHA1 domain p450 PF00067.22 PIK53423.1 - 5.7e-89 299.0 0.0 6.4e-89 298.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ig_3 PF13927.6 PIK53424.1 - 1.2e-27 96.3 0.4 5.1e-11 43.0 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK53424.1 - 7.7e-23 80.4 0.0 2.5e-08 33.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK53424.1 - 1.1e-20 73.8 1.0 8.2e-11 42.1 0.1 3.7 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK53424.1 - 1.6e-10 41.0 0.2 0.03 14.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK53424.1 - 7.8e-10 38.9 0.8 0.0026 17.9 0.0 3.9 3 1 1 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK53424.1 - 3.3e-05 23.9 0.1 0.077 13.1 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.11 PIK53424.1 - 0.013 15.5 0.5 0.13 12.2 0.1 2.5 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain C1-set PF07654.15 PIK53424.1 - 0.028 14.8 0.3 5.6 7.4 0.1 3.1 3 0 0 3 3 3 0 Immunoglobulin C1-set domain DNA_pol_phi PF04931.13 PIK53424.1 - 0.034 12.3 45.8 0.047 11.8 45.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mpp10 PF04006.12 PIK53424.1 - 0.16 10.4 20.4 0.2 10.1 20.4 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 PIK53424.1 - 0.23 9.7 23.0 0.32 9.2 23.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 PIK53424.1 - 0.48 8.6 32.7 0.65 8.1 32.7 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4637 PF15470.6 PIK53424.1 - 0.57 9.9 10.6 0.31 10.7 8.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Glu-tRNAGln PF02686.15 PIK53425.1 - 1.6e-08 34.7 0.3 3e-08 33.8 0.3 1.4 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit UPF0203 PF05254.12 PIK53426.1 - 2e-24 85.6 2.1 2.5e-24 85.3 2.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 PIK53426.1 - 0.00042 20.5 3.2 0.14 12.4 0.2 2.1 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 PIK53426.1 - 0.0027 17.7 0.7 0.92 9.6 0.0 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 PIK53426.1 - 0.0077 16.6 0.6 0.031 14.6 0.6 1.8 1 1 1 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 PIK53426.1 - 0.0087 16.2 2.4 0.043 14.0 2.2 2.0 1 1 1 2 2 2 1 CHCH domain CX9C PF16860.5 PIK53426.1 - 0.011 15.7 1.2 0.15 12.1 0.1 2.2 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF5339 PF17274.2 PIK53426.1 - 0.026 15.4 2.3 0.61 11.0 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5339) Pet191_N PF10203.9 PIK53426.1 - 0.28 11.5 2.0 4.6 7.6 0.1 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 GIDE PF12483.8 PIK53427.1 - 1e-24 86.7 0.0 1.6e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 E3 Ubiquitin ligase zf-C3HC4_3 PF13920.6 PIK53427.1 - 4.6e-11 42.4 15.7 4.6e-11 42.4 15.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK53427.1 - 1.4e-05 24.8 16.0 3.1e-05 23.7 16.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK53427.1 - 0.018 15.0 14.8 0.018 15.0 14.8 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 PIK53427.1 - 0.02 15.2 16.9 0.02 15.2 16.9 2.1 2 0 0 2 2 2 0 Ring finger domain DUF202 PF02656.15 PIK53427.1 - 0.042 14.3 0.9 0.12 12.8 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF4195 PF13836.6 PIK53428.1 - 0.81 9.8 11.9 0.049 13.7 6.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4195) SH2 PF00017.24 PIK53429.1 - 2.1e-15 56.6 0.5 4.1e-15 55.6 0.1 1.8 2 0 0 2 2 2 1 SH2 domain TPMT PF05724.11 PIK53430.1 - 3e-29 102.3 0.0 3.8e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 PIK53430.1 - 0.032 14.9 0.0 0.074 13.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 PIK53431.1 - 1.3e-34 119.8 0.0 1.5e-34 119.6 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 PIK53431.1 - 0.036 14.7 0.0 0.097 13.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DnaB_bind PF10410.9 PIK53431.1 - 0.093 12.9 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase TPR_19 PF14559.6 PIK53432.1 - 1e-22 80.4 6.2 1.3e-05 25.6 0.0 6.2 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK53432.1 - 5.8e-18 63.5 16.4 0.042 14.0 0.0 9.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK53432.1 - 9.7e-13 47.8 11.1 0.18 12.7 0.5 7.5 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK53432.1 - 3.1e-12 45.7 11.0 2 8.8 0.0 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK53432.1 - 4.3e-12 45.3 19.1 0.18 11.7 3.6 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK53432.1 - 1.2e-09 38.7 16.9 0.0057 17.3 0.0 6.2 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK53432.1 - 2.5e-09 37.3 22.9 0.19 12.0 0.1 8.0 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 PIK53432.1 - 3.7e-09 36.6 13.7 4.3 8.2 0.0 9.1 9 0 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK53432.1 - 6.3e-08 32.7 21.0 0.28 11.4 0.0 6.7 6 2 1 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 PIK53432.1 - 1.2e-06 27.9 10.0 0.0054 16.0 0.5 3.9 2 2 1 4 4 4 3 Tetratricopeptide repeat PknG_TPR PF16918.5 PIK53432.1 - 4.6e-06 25.6 3.8 0.0031 16.3 0.2 3.1 2 1 1 3 3 3 2 Protein kinase G tetratricopeptide repeat TPR_11 PF13414.6 PIK53432.1 - 8.1e-05 22.2 12.2 2 8.1 3.6 6.0 8 0 0 8 8 7 1 TPR repeat TPR_20 PF14561.6 PIK53432.1 - 0.00026 21.2 9.1 1.3 9.4 0.1 4.7 2 2 1 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK53432.1 - 0.00063 18.9 0.1 0.073 12.1 0.0 2.6 2 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 PIK53432.1 - 0.003 17.5 15.1 13 6.0 1.0 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_21 PF09976.9 PIK53432.1 - 0.0056 16.4 15.4 0.4 10.4 0.1 4.4 3 2 2 5 5 5 1 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 PIK53432.1 - 0.078 13.4 13.1 0.52 10.8 0.1 5.8 7 0 0 7 7 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK53432.1 - 0.085 12.8 22.5 0.49 10.3 3.7 6.6 8 0 0 8 8 8 0 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK53432.1 - 0.098 12.7 1.9 9.5 6.4 0.0 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 5 BTAD PF03704.17 PIK53432.1 - 0.12 12.8 0.2 0.12 12.8 0.2 2.5 3 0 0 3 3 3 0 Bacterial transcriptional activator domain ANAPC3 PF12895.7 PIK53433.1 - 0.0011 19.2 0.4 0.068 13.4 0.4 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 NatB_MDM20 PF09797.9 PIK53434.1 - 5.1e-95 318.6 1.0 6.4e-95 318.3 1.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit zf-C3HC4_4 PF15227.6 PIK53435.1 - 5.7e-06 26.4 8.1 5.7e-06 26.4 8.1 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 PIK53435.1 - 8.3e-06 25.9 11.4 8.3e-06 25.9 11.4 3.1 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4 PF00097.25 PIK53435.1 - 3.8e-05 23.5 5.9 3.8e-05 23.5 5.9 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK53435.1 - 6.4e-05 22.9 4.1 6.4e-05 22.9 4.1 3.5 2 1 1 3 3 3 1 RING-type zinc-finger NHL PF01436.21 PIK53435.1 - 0.00012 21.9 0.7 3 8.0 0.0 3.6 3 0 0 3 3 3 2 NHL repeat zf-C3HC4_2 PF13923.6 PIK53435.1 - 0.0002 21.1 8.3 0.0002 21.1 8.3 3.3 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK53435.1 - 0.0012 19.2 7.8 0.0012 19.2 7.8 3.2 2 0 0 2 2 2 1 Ring finger domain Lactonase PF10282.9 PIK53435.1 - 0.0016 17.8 0.0 0.039 13.2 0.0 2.2 1 1 2 3 3 3 3 Lactonase, 7-bladed beta-propeller zf-RING_5 PF14634.6 PIK53435.1 - 0.0042 17.0 3.8 0.0042 17.0 3.8 3.7 3 2 0 3 3 2 1 zinc-RING finger domain zf-RING_10 PF16685.5 PIK53435.1 - 0.012 15.7 4.1 0.012 15.7 4.1 3.2 4 0 0 4 4 3 0 zinc RING finger of MSL2 DUF3920 PF13058.6 PIK53435.1 - 0.043 14.0 0.7 12 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3920) U-box PF04564.15 PIK53435.1 - 0.084 13.1 0.1 0.27 11.4 0.1 1.9 1 0 0 1 1 1 0 U-box domain SBBP PF06739.11 PIK53435.1 - 0.12 12.4 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Beta-propeller repeat Spore_III_AB PF09548.10 PIK53435.1 - 0.13 12.3 1.9 0.25 11.4 1.5 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF740 PF05340.12 PIK53435.1 - 0.51 9.0 3.8 0.16 10.7 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF740) WD40 PF00400.32 PIK53436.1 - 4.5e-18 65.3 4.3 0.0052 17.6 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53436.1 - 2e-06 28.0 0.1 0.63 10.4 0.0 4.3 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain MAM PF00629.23 PIK53438.1 - 3.9e-24 85.4 0.3 7e-23 81.3 0.0 2.2 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK53438.1 - 1.5e-05 25.1 12.6 1.5e-05 25.1 12.6 3.1 2 2 2 4 4 4 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK53439.1 - 5.1e-75 250.8 10.3 1.7e-25 89.8 0.1 4.1 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK53439.1 - 6.1e-06 26.3 14.5 6.1e-06 26.3 14.5 3.0 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Ribosomal_L23 PF00276.20 PIK53439.1 - 0.069 13.5 0.0 14 6.1 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L23 Pterin_4a PF01329.19 PIK53440.1 - 4.6e-32 110.0 0.2 5.6e-32 109.8 0.2 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase zf-CXXC PF02008.20 PIK53441.1 - 2.4e-14 53.1 18.3 2.4e-14 53.1 18.3 2.3 2 0 0 2 2 2 1 CXXC zinc finger domain RcpC PF16976.5 PIK53441.1 - 0.081 13.0 2.3 0.11 12.5 0.2 2.3 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB PHD PF00628.29 PIK53442.1 - 7.5e-21 73.8 58.3 5.1e-09 35.9 8.4 4.6 2 1 2 4 4 4 3 PHD-finger PHD_2 PF13831.6 PIK53442.1 - 5.1e-06 25.9 6.6 5.1e-06 25.9 6.6 5.5 4 2 0 4 4 4 3 PHD-finger zf-HC5HC2H PF13771.6 PIK53443.1 - 7e-11 42.2 8.7 2.3e-10 40.6 8.7 2.0 1 0 0 1 1 1 1 PHD-like zinc-binding domain FYRN PF05964.14 PIK53443.1 - 1.7e-09 37.4 0.0 3.2e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-HC5HC2H_2 PF13832.6 PIK53443.1 - 5.1e-09 36.3 8.0 1.2e-08 35.1 8.0 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain FYRC PF05965.14 PIK53444.1 - 5.7e-17 61.7 0.0 1.4e-16 60.4 0.0 1.8 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.28 PIK53444.1 - 1.5e-16 61.2 1.2 1.5e-16 61.2 1.2 2.3 2 1 0 2 2 2 1 SET domain PIH1 PF08190.12 PIK53445.1 - 3.9e-05 23.2 0.1 4.6e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 PIH1 N-terminal domain NKAP PF15692.5 PIK53446.1 - 6.1e-05 23.7 10.0 6.1e-05 23.7 10.0 3.5 2 1 1 3 3 3 1 NF-kappa-B-activating protein LRR_8 PF13855.6 PIK53447.1 - 5.1e-25 87.0 19.6 2.8e-09 36.6 7.4 4.6 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK53447.1 - 3.5e-22 78.1 30.4 1.9e-06 28.1 5.2 5.8 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK53447.1 - 1.3e-08 34.6 8.6 0.00018 21.0 2.4 2.9 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK53447.1 - 7.9e-07 28.8 24.6 4.5 8.2 0.0 8.8 8 1 1 9 9 9 4 Leucine Rich Repeat SR-25 PF10500.9 PIK53447.1 - 4.8 6.7 9.8 6.6 6.3 9.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 PIK53447.1 - 7.5 7.3 10.5 11 6.7 10.5 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein ABC2_membrane_3 PF12698.7 PIK53449.1 - 9.8e-38 130.1 10.7 1.3e-37 129.7 10.7 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 PIK53449.1 - 3.6e-33 114.8 11.9 4.8e-32 111.1 11.8 2.2 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_2 PF12679.7 PIK53449.1 - 5.4e-09 35.8 6.0 9e-09 35.0 6.0 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 PIK53449.1 - 5.6e-07 30.2 0.0 1e-06 29.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 PIK53449.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Mannitol_dh PF01232.23 PIK53449.1 - 0.12 12.5 0.1 6.9 6.8 0.1 2.2 2 0 0 2 2 2 0 Mannitol dehydrogenase Rossmann domain Ig_3 PF13927.6 PIK53450.1 - 2.3e-27 95.4 0.1 3.6e-16 59.5 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK53450.1 - 4.6e-26 90.7 0.0 1.5e-15 57.1 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK53450.1 - 5.4e-20 71.5 0.1 1.4e-09 38.2 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK53450.1 - 1.1e-18 67.2 0.3 6.6e-10 39.0 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK53450.1 - 8.1e-10 38.8 0.2 0.009 16.2 0.0 4.1 3 1 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK53450.1 - 5.9e-08 32.7 0.0 0.00022 21.2 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK53450.1 - 0.0021 17.6 0.0 0.39 10.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 PIK53450.1 - 0.0037 17.5 0.2 33 4.9 0.0 3.4 3 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain DIX PF00778.17 PIK53451.1 - 1.5e-32 111.3 0.1 2.8e-32 110.4 0.1 1.5 1 0 0 1 1 1 1 DIX domain WEMBL PF05701.11 PIK53451.1 - 0.0018 17.0 16.1 0.0018 17.0 16.1 1.8 1 1 1 2 2 2 1 Weak chloroplast movement under blue light ATG16 PF08614.11 PIK53451.1 - 0.0045 17.2 26.7 0.0045 17.2 26.7 2.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 PIK53451.1 - 0.017 15.2 9.3 0.017 15.2 9.3 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding FliS PF02561.14 PIK53451.1 - 0.046 14.0 2.5 0.11 12.7 2.5 1.6 1 0 0 1 1 1 0 Flagellar protein FliS GAS PF13851.6 PIK53451.1 - 0.097 12.0 30.0 0.23 10.8 21.0 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 PIK53451.1 - 0.1 11.5 27.6 1.3 7.8 4.6 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.10 PIK53451.1 - 0.31 11.4 23.7 0.51 10.7 5.3 3.3 3 0 0 3 3 3 0 Tup N-terminal DUF2891 PF11199.8 PIK53451.1 - 0.4 9.6 2.9 0.64 8.9 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) Uds1 PF15456.6 PIK53451.1 - 0.84 9.8 18.3 0.41 10.8 0.2 3.5 2 1 1 3 3 3 0 Up-regulated During Septation Phage_tail_APC PF16778.5 PIK53451.1 - 0.99 9.3 3.9 0.73 9.8 1.2 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone protein HIP1_clath_bdg PF16515.5 PIK53451.1 - 1.1 9.9 31.8 1.6 9.4 4.9 3.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fib_alpha PF08702.10 PIK53451.1 - 1.9 8.7 25.9 2.3 8.4 0.5 3.8 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.6 PIK53451.1 - 2 8.8 23.2 98 3.4 23.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) SpecificRecomb PF10136.9 PIK53451.1 - 3.1 6.0 8.1 4.3 5.5 8.1 1.3 1 0 0 1 1 1 0 Site-specific recombinase DUF1664 PF07889.12 PIK53451.1 - 4.2 7.4 17.0 3.3 7.8 6.5 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 PIK53451.1 - 7.3 6.6 16.3 4.7 7.2 8.7 2.7 1 1 1 2 2 2 0 Laminin Domain II UPF0242 PF06785.11 PIK53451.1 - 7.9 6.5 32.3 7.6 6.6 26.6 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 PIK53451.1 - 7.9 6.5 15.3 1.1 9.4 7.5 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CREPT PF16566.5 PIK53451.1 - 8.8 6.5 18.4 12 6.1 9.8 2.6 1 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Exonuc_VII_L PF02601.15 PIK53451.1 - 9.7 5.6 24.8 6.5e+02 -0.3 24.7 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit DDE_3 PF13358.6 PIK53452.1 - 3.1e-09 36.7 0.2 4.9e-09 36.1 0.1 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF3225 PF11533.8 PIK53452.1 - 0.033 13.9 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) HTH_Tnp_Tc3_2 PF01498.18 PIK53453.1 - 1.3e-09 38.1 0.9 3e-09 37.0 0.9 1.6 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 PIK53453.1 - 3.1e-05 24.5 4.1 0.0001 22.8 1.1 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_31 PF13560.6 PIK53453.1 - 0.0026 18.1 1.5 0.0085 16.4 0.2 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 PIK53453.1 - 0.013 15.5 0.9 0.063 13.4 0.1 2.3 2 1 0 2 2 2 0 Helix-turn-helix TrmB PF01978.19 PIK53453.1 - 0.029 14.2 0.1 0.065 13.1 0.1 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 PIK53453.1 - 0.046 13.5 2.8 2.5 8.0 0.1 2.8 2 1 0 2 2 2 0 Homeodomain-like domain HTH_7 PF02796.15 PIK53453.1 - 0.087 12.9 0.7 2.3 8.4 0.1 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_25 PF13413.6 PIK53453.1 - 0.18 11.7 1.4 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_19 PF12844.7 PIK53453.1 - 0.19 11.8 1.3 1 9.4 0.2 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.6 PIK53453.1 - 0.32 11.1 2.4 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn helix SRCR PF00530.18 PIK53454.1 - 4e-91 300.0 23.1 2.9e-28 98.3 1.5 5.1 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53454.1 - 8.7e-29 100.0 12.0 3.2e-06 27.6 0.1 5.3 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53454.1 - 5.2e-14 52.7 0.2 0.44 11.1 0.0 5.4 5 0 0 5 5 5 4 Hepsin, SRCR domain YecR PF13992.6 PIK53454.1 - 1.4e-07 31.7 3.8 4.5 7.6 0.0 5.4 5 0 0 5 5 5 3 YecR-like lipoprotein SapB_2 PF03489.17 PIK53454.1 - 0.002 18.2 0.0 41 4.4 0.0 5.0 5 0 0 5 5 5 0 Saposin-like type B, region 2 Lactamase_B_3 PF13483.6 PIK53454.1 - 0.0072 16.2 0.1 0.027 14.4 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DFF40 PF09230.10 PIK53455.1 - 9.4e-30 103.9 3.8 1.1e-29 103.7 3.8 1.0 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa PKcGMP_CC PF16808.5 PIK53455.1 - 0.019 14.8 0.8 0.031 14.1 0.8 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Viral_env_E26 PF11050.8 PIK53455.1 - 0.03 13.7 0.1 0.035 13.5 0.1 1.1 1 0 0 1 1 1 0 Virus envelope protein E26 CIDE-N PF02017.15 PIK53456.1 - 1e-13 51.1 0.0 1.8e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 CIDE-N domain DUF2064 PF09837.9 PIK53457.1 - 0.0074 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2064) CIDE-N PF02017.15 PIK53458.1 - 2.5e-13 49.9 0.0 4.2e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 CIDE-N domain Hexapep_2 PF14602.6 PIK53458.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase DFF40 PF09230.10 PIK53459.1 - 1.4e-34 119.7 2.7 1.4e-34 119.7 2.7 2.8 3 0 0 3 3 3 1 DNA fragmentation factor 40 kDa Exo_endo_phos PF03372.23 PIK53461.1 - 7.3e-05 22.4 0.0 0.0013 18.3 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK53461.1 - 0.0072 16.2 0.0 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase EamA PF00892.20 PIK53463.1 - 1.4e-24 86.8 26.3 4.1e-15 56.2 9.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family Yip1 PF04893.17 PIK53463.1 - 0.053 13.2 24.8 0.022 14.5 9.5 2.6 2 1 1 3 3 3 0 Yip1 domain MNE1 PF13762.6 PIK53463.1 - 0.15 12.0 4.3 0.19 11.7 0.9 2.4 2 1 1 3 3 3 0 Mitochondrial splicing apparatus component LRR19-TM PF15176.6 PIK53463.1 - 0.38 10.8 1.0 0.85 9.6 1.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain ZU5 PF00791.20 PIK53464.1 - 9.7e-15 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 ZU5 domain C2-set_2 PF08205.12 PIK53465.1 - 0.016 15.3 0.5 0.79 9.8 0.0 2.9 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK53465.1 - 0.016 15.2 0.3 0.075 13.1 0.0 2.3 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53465.1 - 0.23 12.1 6.8 1.7 9.3 0.0 3.8 3 1 0 3 3 3 0 Immunoglobulin domain Insulin PF00049.18 PIK53467.1 - 1.4e-11 45.2 1.5 1.4e-11 45.2 1.5 3.7 2 1 0 2 2 2 1 Insulin/IGF/Relaxin family Ins_beta PF03488.14 PIK53467.1 - 0.086 12.9 4.9 3.1 7.9 0.1 2.5 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type UDPGT PF00201.18 PIK53469.1 - 8.7e-09 34.7 0.0 2.5e-08 33.2 0.0 1.6 1 1 1 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 PIK53470.1 - 4.6e-83 279.7 0.0 5.4e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK53470.1 - 0.0007 19.6 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Atg14 PF10186.9 PIK53471.1 - 0.23 10.5 8.6 0.24 10.4 8.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BSP_II PF05432.11 PIK53471.1 - 0.42 10.2 13.0 0.53 9.9 13.0 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) K_channel_TID PF07941.11 PIK53471.1 - 0.55 10.7 6.9 0.11 12.9 3.0 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain CDC45 PF02724.14 PIK53471.1 - 2.7 6.2 13.8 2.8 6.1 13.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 PIK53471.1 - 3.4 6.6 8.6 3.9 6.4 8.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 PIK53471.1 - 4.6 5.3 7.6 4.5 5.3 7.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FTZ PF03867.14 PIK53472.1 - 0.21 11.1 4.8 0.3 10.6 4.8 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region MGC-24 PF05283.11 PIK53472.1 - 0.53 10.7 2.2 0.84 10.1 2.2 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TMEM70 PF06979.12 PIK53473.1 - 2e-35 122.0 0.1 2.8e-35 121.6 0.1 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Mononeg_mRNAcap PF14318.6 PIK53473.1 - 0.019 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V CAAP1 PF15335.6 PIK53475.1 - 1.1e-23 83.6 0.3 2e-23 82.7 0.3 1.5 1 0 0 1 1 1 1 Caspase activity and apoptosis inhibitor 1 PMSI1 PF15322.6 PIK53475.1 - 0.95 8.8 7.0 3.8 6.9 0.4 2.1 2 0 0 2 2 2 0 Protein missing in infertile sperm 1, putative WD40 PF00400.32 PIK53476.1 - 0.00016 22.4 0.1 0.00035 21.3 0.1 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat PPP4R2 PF09184.11 PIK53476.1 - 2.8 7.4 21.3 4.3 6.8 21.3 1.2 1 0 0 1 1 1 0 PPP4R2 WD40 PF00400.32 PIK53477.1 - 3.2e-13 49.9 4.0 0.00026 21.7 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53477.1 - 0.00017 21.8 0.0 0.34 11.2 0.0 3.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK53477.1 - 0.0054 15.7 0.0 0.042 12.8 0.0 2.2 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK53477.1 - 0.0091 14.7 0.7 1.4 7.4 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Glycos_transf_1 PF00534.20 PIK53478.1 - 5.4e-37 127.0 0.0 9.9e-37 126.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK53478.1 - 6.4e-17 62.2 0.0 9.8e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 PIK53478.1 - 9.4e-17 61.5 0.0 1.3e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 PIK53478.1 - 6.1e-08 33.3 0.0 9.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 PIK53478.1 - 0.00095 19.5 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_5 PF16994.5 PIK53478.1 - 0.21 11.2 0.0 0.79 9.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Pkinase PF00069.25 PIK53479.1 - 9.1e-68 228.5 0.0 1.1e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53479.1 - 4e-32 111.5 0.0 5.1e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK53479.1 - 8.1e-09 35.2 0.0 1.5e-08 34.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK53479.1 - 0.0014 17.6 0.1 0.002 17.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain WD40 PF00400.32 PIK53480.1 - 1.5e-05 25.6 0.3 1.6 9.7 0.0 4.6 4 1 0 4 4 4 2 WD domain, G-beta repeat ASF1_hist_chap PF04729.13 PIK53481.1 - 8.7e-45 152.4 0.6 1.3e-38 132.4 0.1 2.3 2 0 0 2 2 2 2 ASF1 like histone chaperone Peptidase_A17 PF05380.13 PIK53482.1 - 9.6e-32 110.2 0.1 1.8e-31 109.3 0.0 1.4 2 0 0 2 2 2 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK53482.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) COG6 PF06419.11 PIK53482.1 - 0.1 10.8 0.0 0.14 10.3 0.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Sulfatase PF00884.23 PIK53483.1 - 1.1e-69 235.3 0.3 1.5e-69 234.8 0.3 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK53483.1 - 0.00011 23.0 0.0 0.00031 21.5 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 PIK53483.1 - 0.099 12.6 0.0 0.49 10.3 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function ArsA_ATPase PF02374.15 PIK53484.1 - 2e-100 335.9 0.0 2.7e-100 335.5 0.0 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase Phospholip_A2_1 PF00068.19 PIK53484.1 - 1e-21 77.5 11.6 2.5e-21 76.2 11.6 1.7 1 0 0 1 1 1 1 Phospholipase A2 CbiA PF01656.23 PIK53484.1 - 7.8e-10 38.9 0.0 2.3e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 PIK53484.1 - 5.3e-09 36.2 0.0 2.7e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 PIK53484.1 - 5.1e-05 23.0 0.0 0.0083 15.8 0.0 2.6 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 PIK53484.1 - 5.2e-05 22.8 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 PIK53484.1 - 7.6e-05 22.3 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 PIK53484.1 - 0.00026 20.5 0.0 0.00065 19.2 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PhoH PF02562.16 PIK53484.1 - 0.031 13.7 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 PIK53484.1 - 0.032 14.6 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 PIK53484.1 - 0.051 13.2 0.0 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 PIK53484.1 - 0.13 11.5 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Phospholip_A2_2 PF05826.12 PIK53484.1 - 0.45 10.8 16.3 1.2 9.4 7.8 2.8 1 1 1 2 2 2 0 Phospholipase A2 UDPGT PF00201.18 PIK53486.1 - 2.1e-89 300.6 0.1 1.6e-54 185.5 0.1 2.0 1 1 1 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK53486.1 - 0.0096 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DOMON PF03351.17 PIK53487.1 - 0.022 15.0 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 DOMON domain Vault PF01505.18 PIK53488.1 - 0.12 12.6 0.7 6.4 7.0 0.0 2.9 2 2 0 2 2 2 0 Major Vault Protein repeat domain Cytochrom_B561 PF03188.16 PIK53489.1 - 1e-05 25.7 4.5 1e-05 25.7 4.5 2.0 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF4064 PF13273.6 PIK53489.1 - 0.015 15.6 0.7 0.015 15.6 0.7 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Ni_hydr_CYTB PF01292.20 PIK53489.1 - 0.41 10.2 14.2 3.9 7.0 13.5 2.1 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Baculo_11_kDa PF06143.11 PIK53489.1 - 0.41 10.3 0.0 0.41 10.3 0.0 3.8 3 1 1 4 4 4 0 Baculovirus 11 kDa family DUF4079 PF13301.6 PIK53489.1 - 0.43 10.7 10.9 0.39 10.9 6.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Ninjurin PF04923.12 PIK53489.1 - 0.51 10.3 14.1 0.5 10.3 0.8 2.3 2 0 0 2 2 2 0 Ninjurin DUF3671 PF12420.8 PIK53489.1 - 0.83 9.7 13.9 0.31 11.1 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function NPCC PF08058.11 PIK53489.1 - 3.2 7.8 14.8 1.9 8.5 0.2 3.0 2 1 1 3 3 3 0 Nuclear pore complex component LapA_dom PF06305.11 PIK53489.1 - 4.6 7.1 0.0 4.6 7.1 0.0 3.4 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 PIK53489.1 - 8.9 7.3 0.0 8.9 7.3 0.0 4.1 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain TFR_dimer PF04253.15 PIK53490.1 - 1.6e-24 86.3 0.0 2.7e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 PIK53490.1 - 3.1e-11 43.3 0.0 1.1e-09 38.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M28 WD40 PF00400.32 PIK53491.1 - 6.4e-37 124.9 14.1 1.1e-07 32.4 0.2 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53491.1 - 0.00011 22.4 0.1 0.12 12.7 0.0 4.3 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK53491.1 - 0.00092 18.6 0.0 0.044 13.1 0.0 2.4 3 0 0 3 3 3 1 WD40-like domain EF-1_beta_acid PF10587.9 PIK53491.1 - 9.1 6.8 14.7 0.079 13.4 4.5 2.7 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region Pkinase PF00069.25 PIK53492.1 - 2.8e-33 115.4 0.1 2.4e-30 105.8 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53492.1 - 1e-32 113.5 0.1 9.3e-32 110.3 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Death PF00531.22 PIK53492.1 - 0.00027 21.0 0.1 0.00073 19.6 0.1 1.7 1 1 0 1 1 1 1 Death domain His_Phos_1 PF00300.22 PIK53493.1 - 1.2e-33 116.5 0.0 1.7e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.18 PIK53493.1 - 2.1e-27 95.9 1.7 3.7e-27 95.1 1.7 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_2 PF00328.22 PIK53493.1 - 0.05 13.0 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) zf-CCHC PF00098.23 PIK53494.1 - 0.0014 18.6 2.2 0.0014 18.6 2.2 3.0 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK53494.1 - 0.013 15.2 12.7 0.31 10.8 1.2 2.8 3 0 0 3 3 3 0 Zinc knuckle OTU PF02338.19 PIK53495.1 - 5.3e-09 36.6 0.0 9e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease UN_NPL4 PF11543.8 PIK53495.1 - 2.7e-05 24.6 0.0 5.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Peptidase_C65 PF10275.9 PIK53495.1 - 0.013 15.0 0.1 0.056 12.9 0.1 1.9 1 1 1 2 2 2 0 Peptidase C65 Otubain zf-C2H2_2 PF12756.7 PIK53495.1 - 0.065 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) UBX PF00789.20 PIK53495.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 UBX domain Sulfotransfer_2 PF03567.14 PIK53496.1 - 1.1e-23 84.4 1.0 2.6e-23 83.2 1.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Methyltransf_23 PF13489.6 PIK53497.1 - 6.3e-06 26.1 0.1 1.3e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK53497.1 - 1.2e-05 26.0 0.0 6.1e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK53497.1 - 0.0047 17.6 0.0 0.016 15.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK53497.1 - 0.023 15.3 0.0 0.18 12.4 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain ABC_tran PF00005.27 PIK53498.1 - 3.7e-48 163.5 0.9 5e-27 95.1 0.0 2.9 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 PIK53498.1 - 4.2e-44 151.2 18.2 1.6e-29 103.4 18.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 PIK53498.1 - 2.9e-09 36.7 3.8 0.022 14.2 0.2 4.2 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 PIK53498.1 - 1.2e-06 28.1 0.8 0.0028 17.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 PIK53498.1 - 0.0002 21.4 0.3 0.2 11.7 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK53498.1 - 0.0019 18.1 3.4 0.018 14.9 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_24 PF13479.6 PIK53498.1 - 0.0041 16.9 0.1 0.42 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK53498.1 - 0.0049 16.4 0.1 0.51 9.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Dynamin_N PF00350.23 PIK53498.1 - 0.0054 16.8 3.7 0.076 13.1 0.0 3.2 3 0 0 3 3 3 1 Dynamin family AAA_16 PF13191.6 PIK53498.1 - 0.0078 16.6 0.1 1.6 9.1 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 PIK53498.1 - 0.012 16.1 7.0 0.48 10.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 PIK53498.1 - 0.016 14.9 4.0 0.35 10.5 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 PIK53498.1 - 0.031 14.6 3.3 1.3 9.3 0.0 3.1 4 0 0 4 4 3 0 AAA domain AAA_25 PF13481.6 PIK53498.1 - 0.039 13.5 0.0 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 PIK53498.1 - 0.046 13.5 2.3 0.43 10.3 0.0 3.2 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system TrwB_AAD_bind PF10412.9 PIK53498.1 - 0.075 11.9 1.0 4.8 6.0 0.2 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain S_4TM PF18159.1 PIK53498.1 - 0.084 12.2 0.9 0.23 10.7 0.9 1.7 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain AAA_13 PF13166.6 PIK53498.1 - 0.089 11.4 0.4 0.25 9.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 PIK53498.1 - 0.099 11.8 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 PIK53498.1 - 0.14 11.7 1.2 0.31 10.6 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 PIK53498.1 - 0.25 10.6 1.3 16 4.7 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 PIK53498.1 - 0.26 11.0 2.1 50 3.5 0.0 3.8 5 0 0 5 5 5 0 IstB-like ATP binding protein DUF87 PF01935.17 PIK53498.1 - 2.3 8.2 6.2 2.9 7.9 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain DUF2534 PF10749.9 PIK53498.1 - 4.8 7.4 8.8 5.1 7.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) FYVE_2 PF02318.16 PIK53500.1 - 2.5e-10 40.6 7.5 7.9e-10 39.0 7.5 1.9 1 0 0 1 1 1 1 FYVE-type zinc finger FYVE PF01363.21 PIK53500.1 - 0.0013 18.9 2.8 0.0032 17.6 2.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger zf-piccolo PF05715.13 PIK53500.1 - 0.012 15.8 2.9 0.029 14.5 2.9 1.7 1 0 0 1 1 1 0 Piccolo Zn-finger zinc_ribbon_5 PF13719.6 PIK53500.1 - 3.6 7.4 4.7 2.3 8.1 0.1 2.6 1 1 0 2 2 2 0 zinc-ribbon domain C2 PF00168.30 PIK53502.1 - 5.9e-16 58.6 0.0 1.4e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 PIK53502.1 - 0.015 15.1 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 PIK53502.1 - 0.024 15.0 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DegS PF05384.11 PIK53502.1 - 0.43 10.1 2.1 0.71 9.3 2.1 1.2 1 0 0 1 1 1 0 Sensor protein DegS DGF-1_C PF11040.8 PIK53503.1 - 0.01 15.8 3.7 0.016 15.2 0.1 3.3 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus TruD PF01142.18 PIK53504.1 - 1.7e-05 23.8 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) NA37 PF04245.13 PIK53504.1 - 0.01 15.4 0.1 0.013 15.0 0.1 1.1 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF1018 PF06252.12 PIK53504.1 - 0.016 16.2 0.3 0.03 15.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) KOW PF00467.29 PIK53504.1 - 0.033 14.2 0.8 0.12 12.4 0.8 2.0 1 1 0 1 1 1 0 KOW motif ArfGap PF01412.18 PIK53504.1 - 0.25 11.4 1.7 0.26 11.4 0.1 1.7 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf 7tm_1 PF00001.21 PIK53505.1 - 8.6e-41 140.0 11.1 1e-40 139.8 11.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK53505.1 - 8.7e-08 31.9 7.0 1.1e-07 31.6 7.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK53505.1 - 9.9e-06 25.1 8.4 1.3e-05 24.7 8.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK53505.1 - 0.00019 21.3 0.4 0.00019 21.3 0.4 2.9 2 1 1 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK53505.1 - 0.00034 20.3 10.7 0.00034 20.3 10.7 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2593 PF10767.9 PIK53505.1 - 0.0021 18.1 1.3 0.0049 16.9 1.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2593) LRR_8 PF13855.6 PIK53506.1 - 8.8e-30 102.3 7.5 7.5e-13 48.0 0.4 4.6 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK53506.1 - 6.4e-16 58.2 7.7 9.3e-06 25.9 0.0 4.8 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) fn3 PF00041.21 PIK53506.1 - 3.7e-12 46.4 2.0 4.4e-10 39.8 0.1 3.0 2 0 0 2 2 2 1 Fibronectin type III domain LRR_5 PF13306.6 PIK53506.1 - 1.4e-08 34.8 0.0 4.9e-08 33.0 0.0 2.0 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ig_3 PF13927.6 PIK53506.1 - 3.4e-08 34.0 1.7 1.2e-07 32.2 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK53506.1 - 2.1e-07 31.0 0.0 9e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK53506.1 - 6.4e-07 29.4 0.0 1.5e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK53506.1 - 7.4e-07 29.4 0.1 2.5e-06 27.7 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 PIK53506.1 - 9.3e-06 25.2 0.6 0.043 13.3 0.2 2.4 1 1 1 2 2 2 2 Leucine-rich repeat V-set PF07686.17 PIK53506.1 - 0.0014 18.8 0.2 0.012 15.7 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain EGF PF00008.27 PIK53506.1 - 0.017 15.4 2.3 0.017 15.4 2.3 3.4 4 0 0 4 4 4 0 EGF-like domain FNIP PF05725.12 PIK53506.1 - 0.034 14.3 0.2 0.034 14.3 0.2 3.0 2 1 1 3 3 3 0 FNIP Repeat Orthoreo_P10 PF07204.11 PIK53506.1 - 0.076 13.0 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 LRRCT PF01463.24 PIK53506.1 - 0.22 12.2 1.2 0.82 10.4 0.2 2.6 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 PIK53506.1 - 0.68 10.7 8.2 53 5.0 0.0 6.0 6 1 0 6 6 5 0 Leucine Rich Repeat LRR_8 PF13855.6 PIK53507.1 - 3.9e-26 90.6 23.8 1.4e-16 60.0 4.1 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK53507.1 - 5.9e-14 52.0 20.2 2.5e-07 30.9 2.5 4.5 2 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK53507.1 - 6.8e-09 35.1 16.2 0.16 12.6 0.1 6.3 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK53507.1 - 1.2e-08 34.7 4.5 3.1e-06 26.8 0.2 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 PIK53507.1 - 8.4e-08 32.2 0.6 2.2e-07 30.9 0.1 1.8 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK53507.1 - 0.00011 22.0 10.2 0.11 12.6 0.1 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRRNT PF01462.18 PIK53507.1 - 0.046 13.4 0.9 0.39 10.4 1.3 2.3 2 1 0 2 2 2 0 Leucine rich repeat N-terminal domain TruD PF01142.18 PIK53508.1 - 2.4e-42 145.3 0.0 1e-41 143.1 0.0 1.8 1 1 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) TIMP PF00965.17 PIK53509.1 - 8.4e-11 42.0 0.0 3.6e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53509.1 - 0.086 12.6 0.3 6.4 6.6 0.2 2.2 2 0 0 2 2 2 0 UNC-6/NTR/C345C module WH2 PF02205.20 PIK53510.1 - 0.00056 19.7 0.1 0.001 18.9 0.1 1.4 1 0 0 1 1 1 1 WH2 motif CAP_N PF01213.19 PIK53510.1 - 0.019 14.5 6.2 0.027 14.0 6.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 PIK53510.1 - 0.09 12.8 5.9 0.054 13.6 3.2 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator KxDL PF10241.9 PIK53512.1 - 0.025 14.9 0.4 0.049 13.9 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein Mrr_N PF14338.6 PIK53512.1 - 0.13 12.4 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Mrr N-terminal domain RVT_1 PF00078.27 PIK53513.1 - 2.2e-10 40.5 0.0 3.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK53514.1 - 2.2e-07 30.6 2.7 3.5e-07 30.0 2.7 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK53514.1 - 0.0063 16.3 0.7 0.019 14.8 0.7 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK53514.1 - 0.078 12.8 1.5 0.12 12.2 1.5 1.3 1 0 0 1 1 1 0 Zinc knuckle Fibrinogen_C PF00147.18 PIK53515.1 - 1.9e-37 129.2 0.1 2.7e-37 128.7 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK53516.1 - 6.2e-22 78.5 16.0 1.1e-21 77.7 16.0 1.4 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK53517.1 - 2.3e-39 135.5 0.9 2.8e-39 135.2 0.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK53518.1 - 3.7e-28 98.8 0.2 2.9e-23 82.8 0.2 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK53518.1 - 4.2e-08 33.3 15.7 6.2e-08 32.8 15.7 1.2 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain c-SKI_SMAD_bind PF08782.10 PIK53518.1 - 0.31 11.3 2.1 0.6 10.4 2.1 1.4 1 0 0 1 1 1 0 c-SKI Smad4 binding domain ABC_tran PF00005.27 PIK53520.1 - 5.7e-09 36.6 0.0 7.2e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter Sybindin PF04099.12 PIK53520.1 - 0.1 12.5 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Sybindin-like family BNR_2 PF13088.6 PIK53521.1 - 3.2e-35 121.8 0.0 4.1e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 PIK53521.1 - 2e-10 40.5 0.0 3.4e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK53521.1 - 0.00016 21.2 24.4 0.028 14.4 0.4 5.8 5 0 0 5 5 5 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 PIK53521.1 - 0.0033 16.3 0.1 0.71 8.6 0.0 2.6 1 1 2 3 3 3 3 Sortilin, neurotensin receptor 3, CyRPA PF18638.1 PIK53521.1 - 0.03 13.5 0.9 2.8 7.0 0.0 3.5 3 1 1 4 4 4 0 Cysteine-Rich Protective Antigen 6 bladed domain BNR_6 PF15899.5 PIK53521.1 - 0.089 12.9 3.7 7.9 6.8 0.2 3.8 3 0 0 3 3 3 0 BNR-Asp box repeat ABC_tran PF00005.27 PIK53522.1 - 1.8e-30 106.2 0.1 3.5e-30 105.3 0.1 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK53522.1 - 4.6e-28 98.6 16.7 6.9e-28 98.1 16.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK53522.1 - 1.6e-07 31.0 2.0 1.9e-05 24.2 0.2 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 PIK53522.1 - 0.0016 17.6 0.1 0.26 10.3 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 PIK53522.1 - 0.048 13.4 0.2 0.11 12.3 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 PIK53522.1 - 0.059 13.1 0.6 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 PIK53522.1 - 0.07 13.2 0.1 0.18 11.9 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 PIK53522.1 - 0.12 12.2 0.3 4.2 7.1 0.5 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 PIK53522.1 - 0.12 12.5 3.0 0.14 12.2 0.2 2.3 3 0 0 3 3 3 0 Helicase HerA, central domain DUF2207 PF09972.9 PIK53522.1 - 0.43 9.3 5.8 5.6 5.6 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) IPTL-CTERM PF18203.1 PIK53522.1 - 2 8.4 6.5 4.7 7.2 6.5 1.6 1 0 0 1 1 1 0 IPTL-CTERM motif HTH_8 PF02954.19 PIK53523.1 - 0.068 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family STAG PF08514.11 PIK53524.1 - 1.3e-37 128.2 0.5 3e-37 127.0 0.5 1.7 1 0 0 1 1 1 1 STAG domain Med30 PF11315.8 PIK53524.1 - 0.044 14.0 2.7 7.6 6.7 0.9 2.8 2 0 0 2 2 2 0 Mediator complex subunit 30 Tho2 PF11262.8 PIK53524.1 - 3.6 6.7 8.2 1.5 8.0 0.8 2.8 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 NPM1-C PF16276.5 PIK53525.1 - 0.071 13.1 0.1 17 5.4 0.0 2.4 2 0 0 2 2 2 0 Nucleophosmin C-terminal domain ATG16 PF08614.11 PIK53526.1 - 4.8e-34 118.3 27.3 6.5e-34 117.9 27.3 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) WD40 PF00400.32 PIK53526.1 - 3.1e-21 75.3 10.9 8e-07 29.7 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53526.1 - 2.7e-06 27.6 0.0 0.26 11.6 0.0 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ERM PF00769.19 PIK53526.1 - 6.4e-05 22.9 4.4 6.4e-05 22.9 4.4 2.1 2 0 0 2 2 2 1 Ezrin/radixin/moesin family Nup160 PF11715.8 PIK53526.1 - 0.0036 16.0 1.2 0.027 13.1 0.3 2.9 1 1 2 3 3 3 1 Nucleoporin Nup120/160 eIF2A PF08662.11 PIK53526.1 - 0.054 13.4 0.0 1.6 8.5 0.0 2.6 1 1 2 3 3 3 0 Eukaryotic translation initiation factor eIF2A Fez1 PF06818.15 PIK53526.1 - 1.1 9.7 26.5 0.27 11.7 17.3 2.1 2 0 0 2 2 2 0 Fez1 GAS PF13851.6 PIK53526.1 - 1.5 8.1 29.3 0.74 9.1 5.8 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 PIK53526.1 - 4.1 7.5 12.2 12 6.0 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-C3HC PF07967.13 PIK53526.1 - 4.9 7.2 6.6 0.84 9.7 1.4 2.3 2 1 1 3 3 3 0 C3HC zinc finger-like Collagen PF01391.18 PIK53527.1 - 8.6e-10 38.2 17.5 1.2e-09 37.7 17.5 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK53528.1 - 8e-10 38.3 15.8 1.5e-09 37.5 15.8 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RRM_1 PF00076.22 PIK53529.1 - 9.9e-21 73.3 0.0 1.9e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK53529.1 - 1.6e-05 25.0 0.0 4.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 PIK53529.1 - 0.00025 20.7 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK53529.1 - 0.055 13.3 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif CRT10 PF08728.10 PIK53529.1 - 0.19 9.9 6.8 0.34 9.0 6.8 1.4 1 0 0 1 1 1 0 CRT10 Filament PF00038.21 PIK53530.1 - 0.0078 15.8 11.1 0.0078 15.8 11.1 2.7 1 1 2 3 3 3 1 Intermediate filament protein FlxA PF14282.6 PIK53530.1 - 2.3 8.2 15.5 0.25 11.4 2.5 3.2 1 1 2 3 3 3 0 FlxA-like protein Csm1_N PF18504.1 PIK53530.1 - 5.3 7.5 23.4 1 9.7 4.4 3.9 2 1 1 4 4 4 0 Csm1 N-terminal domain YabA PF06156.13 PIK53530.1 - 7.1 7.3 27.4 0.058 14.0 4.0 3.6 1 1 1 2 2 2 0 Initiation control protein YabA SlyX PF04102.12 PIK53530.1 - 8.9 7.0 14.9 0.76 10.4 1.0 3.8 1 1 3 4 4 4 0 SlyX MecA_N PF05223.11 PIK53530.1 - 9.8 6.5 12.8 0.76 10.1 3.4 3.1 2 1 2 4 4 4 0 NTF2-like N-terminal transpeptidase domain PNMA PF14893.6 PIK53531.1 - 1.4e-11 44.4 0.0 3.3e-11 43.2 0.0 1.7 2 0 0 2 2 2 1 PNMA RRM_1 PF00076.22 PIK53531.1 - 9.3e-07 28.6 0.2 4.8e-06 26.3 0.0 2.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CdiA_C PF18451.1 PIK53531.1 - 0.0036 17.5 0.0 0.15 12.3 0.0 3.2 3 0 0 3 3 3 1 Contact-dependent growth inhibition CdiA C-terminal domain RRM_3 PF08777.11 PIK53531.1 - 0.044 13.8 0.0 0.32 11.1 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif RVT_1 PF00078.27 PIK53532.1 - 3.1e-36 125.0 0.1 4e-36 124.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MyTH4 PF00784.17 PIK53533.1 - 4.2e-31 107.6 0.2 9.8e-31 106.5 0.2 1.7 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 PIK53533.1 - 1.1e-21 77.4 0.1 5.3e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 PIK53533.1 - 0.00068 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 FERM N-terminal domain PID PF00640.23 PIK53533.1 - 0.006 16.6 0.0 0.039 14.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 PIK53533.1 - 0.042 14.0 0.0 0.098 12.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotyrosine-binding domain FERM_M PF00373.18 PIK53534.1 - 0.00042 20.7 0.1 0.0011 19.4 0.1 1.6 2 0 0 2 2 2 1 FERM central domain SH3_2 PF07653.17 PIK53534.1 - 0.0006 19.4 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ASCH PF04266.14 PIK53534.1 - 0.036 14.7 0.0 0.54 10.9 0.0 2.3 2 0 0 2 2 2 0 ASCH domain SH3_1 PF00018.28 PIK53534.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 SH3 domain MyTH4 PF00784.17 PIK53535.1 - 3.4e-32 111.2 0.0 5.3e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 MyTH4 domain FERM_N PF09379.10 PIK53535.1 - 3.5e-06 26.9 0.0 7.5e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain RA PF00788.23 PIK53535.1 - 0.0021 18.6 0.0 0.0035 18.0 0.0 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Myosin_head PF00063.21 PIK53536.1 - 8.3e-224 744.7 4.6 2.4e-176 587.9 2.1 2.0 1 1 1 2 2 2 2 Myosin head (motor domain) IQ PF00612.27 PIK53536.1 - 6.6e-13 47.2 24.1 0.00067 19.2 1.4 5.0 5 0 0 5 5 5 4 IQ calmodulin-binding motif T2SSE PF00437.20 PIK53536.1 - 0.0004 19.5 0.1 0.33 10.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 PIK53536.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK53536.1 - 0.012 16.0 0.0 0.033 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 PIK53536.1 - 0.015 15.9 0.0 0.045 14.3 0.0 1.8 2 0 0 2 2 2 0 ABC transporter CAF1-p150_C2 PF15539.6 PIK53537.1 - 0.11 12.0 0.1 0.12 11.8 0.1 1.0 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term DUF2937 PF11157.8 PIK53537.1 - 0.17 11.6 0.1 0.19 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) LapA_dom PF06305.11 PIK53537.1 - 0.69 9.8 1.8 0.96 9.3 1.8 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ras PF00071.22 PIK53538.1 - 5e-47 159.5 0.0 6.4e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK53538.1 - 1.5e-18 67.2 0.0 2.7e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Lipase_GDSL_3 PF14606.6 PIK53538.1 - 0.019 15.1 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family TniB PF05621.11 PIK53538.1 - 0.07 12.5 0.0 0.42 10.0 0.0 2.1 2 1 0 2 2 2 0 Bacterial TniB protein Hydrolase_4 PF12146.8 PIK53539.1 - 3.7e-17 62.4 0.0 2.3e-12 46.7 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK53539.1 - 1.3e-14 54.4 0.1 3.3e-11 43.3 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK53539.1 - 2.9e-08 34.6 0.0 5.7e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 PIK53539.1 - 1.1e-05 25.4 0.0 1.8e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK53539.1 - 1.7e-05 24.4 0.0 4e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.25 PIK53539.1 - 0.00038 20.3 0.0 0.00064 19.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) LIDHydrolase PF10230.9 PIK53539.1 - 0.041 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_S15 PF02129.18 PIK53539.1 - 0.044 13.4 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 PIK53539.1 - 0.062 13.1 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Sld5 PF05916.11 PIK53540.1 - 1.7e-05 25.3 0.1 4.1e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 GINS complex protein YqfQ PF14181.6 PIK53541.1 - 0.013 15.7 3.5 0.022 15.0 3.5 1.3 1 0 0 1 1 1 0 YqfQ-like protein Rap_GAP PF02145.15 PIK53541.1 - 0.04 13.5 0.0 0.13 11.8 0.0 1.8 3 0 0 3 3 3 0 Rap/ran-GAP Rap_GAP PF02145.15 PIK53542.1 - 2.1e-30 105.7 0.1 3.7e-30 104.8 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Pheromone PF08015.11 PIK53542.1 - 0.42 11.7 3.5 4.3 8.4 0.1 3.1 2 0 0 2 2 2 0 Fungal mating-type pheromone Ca_bind_SSO6904 PF18249.1 PIK53543.1 - 0.022 15.1 0.0 0.049 14.0 0.0 1.5 1 0 0 1 1 1 0 Calcium binding protein SSO6904 Cullin_binding PF03556.15 PIK53543.1 - 0.19 12.2 0.7 12 6.4 0.0 2.6 2 0 0 2 2 2 0 Cullin binding TRAP_alpha PF03896.16 PIK53544.1 - 0.0091 15.2 1.3 0.013 14.7 1.3 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 PIK53544.1 - 0.019 14.6 1.6 0.035 13.8 1.6 1.5 1 0 0 1 1 1 0 FAM176 family EOS1 PF12326.8 PIK53544.1 - 0.058 13.3 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 N-glycosylation protein RNA_pol_Rpc4 PF05132.14 PIK53544.1 - 0.15 12.5 0.2 0.15 12.5 0.2 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 PIK53544.1 - 0.24 9.4 5.5 0.34 9.0 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 PIK53544.1 - 5.1 6.8 9.8 0.05 13.4 1.7 1.7 2 0 0 2 2 2 0 Pox virus Ag35 surface protein LRR_9 PF14580.6 PIK53546.1 - 8.7e-17 61.2 0.7 7.2e-14 51.7 0.5 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 PIK53546.1 - 5.5e-10 39.3 19.3 6.4e-06 26.4 0.9 5.4 3 1 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK53546.1 - 7e-08 32.1 24.4 1.3e-05 24.9 6.2 4.4 2 1 3 5 5 5 3 Leucine rich repeat LRR_6 PF13516.6 PIK53546.1 - 0.016 15.3 8.5 4.9 7.5 0.0 4.5 2 1 1 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 PIK53546.1 - 1.1 10.1 8.0 2.2e+02 3.0 0.0 4.9 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_3 PF07725.12 PIK53546.1 - 2.3 8.2 0.0 2.3 8.2 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK53547.1 - 5.4e-24 84.6 2.2 2.3e-12 46.7 0.0 3.5 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 PIK53547.1 - 2.8e-19 68.6 32.3 8.5e-08 31.9 0.6 5.1 5 0 0 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK53547.1 - 2.2e-17 62.8 38.0 6.6e-07 29.5 1.5 6.9 2 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK53547.1 - 0.0037 17.2 35.2 0.038 14.0 0.3 8.7 8 1 1 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.33 PIK53547.1 - 8.4 7.4 36.1 1.6 9.6 0.2 9.4 9 1 0 9 9 9 0 Leucine Rich Repeat LRR_9 PF14580.6 PIK53548.1 - 2.9e-16 59.5 5.6 4.4e-13 49.1 0.7 2.8 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 PIK53548.1 - 4.3e-16 58.7 15.5 0.00015 22.0 0.2 4.5 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK53548.1 - 2.3e-15 56.1 19.3 1.1e-08 34.7 4.1 4.0 2 1 1 4 4 4 4 Leucine rich repeat PDZ_assoc PF10600.9 PIK53548.1 - 0.062 14.1 1.9 6.7 7.6 0.9 2.6 2 0 0 2 2 2 0 PDZ-associated domain of NMDA receptors LRR_1 PF00560.33 PIK53548.1 - 0.13 12.9 16.9 17 6.4 0.4 5.7 5 1 0 5 5 5 0 Leucine Rich Repeat TSNAXIP1_N PF15739.5 PIK53549.1 - 5.1e-22 78.4 3.4 5.1e-22 78.4 3.4 2.7 2 0 0 2 2 2 1 Translin-associated factor X-interacting N-terminus Clathrin_H_link PF13838.6 PIK53549.1 - 3.7e-19 68.4 0.0 9.1e-19 67.1 0.0 1.7 1 0 0 1 1 1 1 Clathrin-H-link GAS PF13851.6 PIK53549.1 - 0.00029 20.2 17.2 0.02 14.3 1.7 2.3 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding FRG1 PF06229.12 PIK53549.1 - 0.036 13.8 1.6 0.29 10.8 1.5 2.2 2 0 0 2 2 2 0 FRG1-like domain Baculo_PEP_C PF04513.12 PIK53549.1 - 0.74 9.9 9.8 0.69 10.0 0.1 3.0 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_1 PF00170.21 PIK53549.1 - 0.78 9.9 15.6 0.1 12.7 0.5 4.1 4 0 0 4 4 4 0 bZIP transcription factor DUF2353 PF09789.9 PIK53549.1 - 2.8 7.2 20.8 1 8.7 10.9 2.3 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) LURAP PF14854.6 PIK53550.1 - 0.00015 21.7 0.1 0.00039 20.4 0.0 1.7 2 0 0 2 2 2 1 Leucine rich adaptor protein Dapper PF15268.6 PIK53550.1 - 0.0094 14.9 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 Dapper HSD3 PF15244.6 PIK53551.1 - 5.2e-25 88.8 3.1 6e-25 88.6 3.1 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 7, or HSD3 Dppa2_A PF14049.6 PIK53551.1 - 0.029 14.5 0.1 0.082 13.1 0.1 1.7 1 0 0 1 1 1 0 Dppa2/4 conserved region in higher vertebrates HSD3 PF15244.6 PIK53552.1 - 1.7e-22 80.6 11.7 2e-12 47.4 1.9 2.1 2 0 0 2 2 2 2 Spermatogenesis-associated protein 7, or HSD3 Med2 PF11214.8 PIK53552.1 - 0.0011 19.0 0.0 0.0041 17.3 0.0 1.8 2 0 0 2 2 2 1 Mediator complex subunit 2 Esterase PF00756.20 PIK53553.1 - 8.9e-06 25.5 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 PIK53553.1 - 0.00021 20.6 0.0 0.002 17.5 0.0 2.2 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK53553.1 - 0.00043 20.0 0.0 0.00084 19.1 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK53553.1 - 0.0066 16.0 0.1 0.014 14.9 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 PIK53553.1 - 0.072 13.7 1.7 0.19 12.3 1.7 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Histone_H2A_C PF16211.5 PIK53554.1 - 1.9e-19 69.1 0.8 3.1e-19 68.4 0.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 PIK53554.1 - 1.8e-15 57.4 0.0 2.7e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 PIK53554.1 - 0.00019 21.6 0.0 0.00029 21.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Forkhead PF00250.18 PIK53555.1 - 2.8e-34 117.2 0.0 4.8e-34 116.5 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain TMEM223 PF14640.6 PIK53556.1 - 2.1e-56 190.6 0.0 2.5e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 zf-CCHH PF10283.9 PIK53557.1 - 2.6e-21 75.3 16.5 7e-11 41.9 7.7 2.4 2 0 0 2 2 2 2 PBZ domain FHA_2 PF17913.1 PIK53557.1 - 8.6e-08 32.3 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 PIK53557.1 - 1.3e-05 25.5 0.0 2.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain HUN PF08729.10 PIK53557.1 - 0.027 14.5 1.3 0.027 14.5 1.3 3.3 2 0 0 2 2 2 0 HPC2 and ubinuclein domain Yop-YscD_cpl PF16697.5 PIK53557.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain zf-CCCH PF00642.24 PIK53557.1 - 3.2 7.8 6.7 11 6.0 1.0 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SRCR PF00530.18 PIK53558.1 - 5.8e-72 238.5 13.4 2.9e-26 91.9 0.3 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53558.1 - 3.6e-18 65.9 11.0 5.3e-05 23.7 0.1 4.3 4 0 0 4 4 4 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53558.1 - 2.9e-07 31.0 0.1 1.1 9.8 0.1 3.7 4 0 0 4 4 4 3 Hepsin, SRCR domain Rax2 PF12768.7 PIK53558.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity YecR PF13992.6 PIK53558.1 - 0.051 13.9 4.6 6.3 7.2 0.0 4.0 4 1 0 4 4 4 0 YecR-like lipoprotein TraL PF07178.11 PIK53558.1 - 0.15 12.6 0.3 0.28 11.7 0.3 1.4 1 0 0 1 1 1 0 TraL protein Phage_Coat_Gp8 PF05371.12 PIK53558.1 - 0.28 11.0 0.4 0.53 10.1 0.4 1.3 1 0 0 1 1 1 0 Phage major coat protein, Gp8 SRCR PF00530.18 PIK53559.1 - 1.1e-58 196.0 5.7 1.4e-28 99.3 0.3 3.2 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53559.1 - 5.5e-19 68.5 5.3 1.8e-05 25.2 0.1 3.3 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53559.1 - 3.6e-09 37.1 0.0 0.08 13.5 0.0 3.3 3 0 0 3 3 3 3 Hepsin, SRCR domain Rax2 PF12768.7 PIK53559.1 - 0.0026 17.3 0.1 0.0046 16.5 0.1 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity YecR PF13992.6 PIK53559.1 - 0.0036 17.6 1.6 11 6.4 0.1 3.8 3 1 0 3 3 3 1 YecR-like lipoprotein TraL PF07178.11 PIK53559.1 - 0.1 13.0 0.3 0.19 12.2 0.3 1.3 1 0 0 1 1 1 0 TraL protein Phage_Coat_Gp8 PF05371.12 PIK53559.1 - 0.23 11.3 0.2 0.41 10.5 0.2 1.3 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Syndecan PF01034.20 PIK53559.1 - 0.25 11.3 0.4 0.46 10.4 0.4 1.3 1 0 0 1 1 1 0 Syndecan domain SRCR PF00530.18 PIK53561.1 - 2.6e-51 172.3 1.8 2.5e-22 79.2 0.0 3.0 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53561.1 - 2.6e-15 56.7 2.3 4.1e-07 30.4 0.2 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53561.1 - 9.2e-07 29.4 0.0 0.011 16.3 0.0 2.2 2 0 0 2 2 2 2 Hepsin, SRCR domain YecR PF13992.6 PIK53561.1 - 0.0081 16.4 0.5 1.3 9.4 0.0 2.7 2 0 0 2 2 2 1 YecR-like lipoprotein SRCR PF00530.18 PIK53562.1 - 3.6e-16 59.5 7.9 1.1e-11 45.2 1.6 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK53562.1 - 0.0006 20.3 1.3 0.001 19.5 1.3 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain 2-oxogl_dehyd_N PF16078.5 PIK53563.1 - 2.4e-19 68.6 0.7 4e-19 67.9 0.7 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus WD40 PF00400.32 PIK53564.1 - 3.5e-41 138.4 28.6 4e-08 33.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53564.1 - 1.3e-08 35.0 0.3 0.0058 16.9 0.0 4.4 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK53564.1 - 0.0027 16.7 1.5 1.7 7.5 0.0 3.1 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK53564.1 - 0.0058 15.3 9.1 0.035 12.8 0.1 3.8 2 2 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 PIK53564.1 - 0.1 12.6 0.0 28 4.8 0.1 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Metallophos PF00149.28 PIK53565.1 - 1.6e-20 74.5 0.1 3.5e-20 73.4 0.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 PIK53565.1 - 0.0053 16.4 0.0 0.0083 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Fibrinogen_C PF00147.18 PIK53566.1 - 6.7e-38 130.7 0.3 2.8e-31 109.0 0.1 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK53566.1 - 0.00012 22.2 3.7 0.00012 22.2 3.7 3.4 3 0 0 3 3 3 1 EGF domain TILa PF12714.7 PIK53566.1 - 0.00026 20.9 4.1 0.00026 20.9 4.1 3.0 3 1 1 4 4 4 1 TILa domain Gemini_BL1 PF00845.19 PIK53566.1 - 0.04 13.5 0.3 0.065 12.8 0.3 1.2 1 0 0 1 1 1 0 Geminivirus BL1 movement protein Fibrinogen_C PF00147.18 PIK53567.1 - 2.4e-34 119.1 0.4 3.9e-34 118.4 0.4 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53567.1 - 1.5e-05 24.9 2.9 1.5e-05 24.9 2.9 2.8 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK53567.1 - 0.0011 19.1 11.1 0.0011 19.1 11.1 3.4 3 2 1 4 4 4 1 EGF domain EGF_2 PF07974.13 PIK53567.1 - 0.015 15.7 8.8 0.015 15.7 8.8 3.2 2 2 0 2 2 2 0 EGF-like domain TILa PF12714.7 PIK53568.1 - 3.4e-06 26.9 5.3 3.4e-06 26.9 5.3 3.4 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK53568.1 - 0.00012 22.2 13.0 0.00012 22.2 13.0 3.6 3 1 1 4 4 4 1 EGF domain TIL PF01826.17 PIK53568.1 - 0.00026 21.1 12.7 0.00026 21.1 12.7 3.1 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK53568.1 - 0.018 15.4 8.3 0.018 15.4 8.3 4.2 3 2 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK53569.1 - 2.1e-45 155.2 12.7 2.6e-45 154.9 12.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF1521 PF07481.11 PIK53569.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1521) RVT_1 PF00078.27 PIK53570.1 - 6.5e-35 120.6 0.2 6.5e-35 120.6 0.2 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK53570.1 - 0.00036 20.1 0.0 0.0021 17.6 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Retrotran_gag_2 PF14223.6 PIK53570.1 - 0.0071 16.0 2.0 0.022 14.4 1.0 2.4 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type RVT_1 PF00078.27 PIK53572.1 - 2.5e-22 79.5 0.0 3.5e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GCFC PF07842.12 PIK53572.1 - 0.053 13.1 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein Thymopoietin PF08198.11 PIK53573.1 - 3.3e-08 33.0 6.2 1.2e-07 31.2 1.0 2.8 3 0 0 3 3 3 1 Thymopoietin protein HeH PF12949.7 PIK53573.1 - 2.7e-06 27.0 0.3 2.7e-06 27.0 0.3 2.5 3 0 0 3 3 3 1 HeH/LEM domain LEM PF03020.15 PIK53573.1 - 8.7e-06 25.2 5.0 0.019 14.5 0.0 3.1 3 0 0 3 3 3 2 LEM domain Nop14 PF04147.12 PIK53573.1 - 0.0053 15.0 14.6 0.009 14.3 14.6 1.3 1 0 0 1 1 1 1 Nop14-like family DUF3311 PF11755.8 PIK53573.1 - 0.054 13.4 3.6 0.13 12.2 3.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) XhlA PF10779.9 PIK53573.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Haemolysin XhlA DNA_pol_phi PF04931.13 PIK53573.1 - 0.14 10.3 16.8 0.16 10.0 15.3 1.7 2 0 0 2 2 2 0 DNA polymerase phi NOA36 PF06524.12 PIK53573.1 - 0.92 8.8 13.9 1.8 7.8 13.9 1.5 1 0 0 1 1 1 0 NOA36 protein Astro_capsid_p PF12226.8 PIK53573.1 - 0.95 8.6 13.3 1.4 8.0 11.4 1.9 2 0 0 2 2 2 0 Turkey astrovirus capsid protein RR_TM4-6 PF06459.12 PIK53573.1 - 1.1 9.0 10.7 2.4 7.9 10.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 PIK53573.1 - 2 6.5 6.0 3 5.9 6.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sporozoite_P67 PF05642.11 PIK53573.1 - 2 6.4 11.0 3.1 5.8 11.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 PIK53573.1 - 2.2 8.7 17.1 6.1 7.3 17.1 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain eIF-3c_N PF05470.12 PIK53573.1 - 4 5.6 13.6 6.1 5.0 13.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Presenilin PF01080.17 PIK53573.1 - 8.7 5.0 7.9 16 4.1 7.9 1.4 1 0 0 1 1 1 0 Presenilin Exo_endo_phos PF03372.23 PIK53574.1 - 1.8e-16 60.4 0.0 3.2e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 PIK53574.1 - 2.1e-10 40.5 4.0 5.6e-10 39.2 4.0 1.8 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 PIK53574.1 - 2.1e-06 27.6 0.0 0.00013 21.8 0.0 2.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase PRO8NT PF08082.11 PIK53575.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain UCH PF00443.29 PIK53577.1 - 1.7e-81 273.5 0.0 7.7e-81 271.4 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 PIK53577.1 - 8.5e-32 109.0 0.9 1.8e-31 108.0 0.9 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.12 PIK53577.1 - 3.6e-20 72.4 0.3 3.6e-20 72.4 0.3 2.7 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 PIK53577.1 - 1e-16 61.5 1.5 9.1e-10 38.6 0.3 3.3 2 1 1 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 PIK53577.1 - 7.2e-07 29.1 2.4 1.7e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 PIK53577.1 - 6.8e-05 22.3 0.3 0.00022 20.7 0.2 1.8 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 zf-C6H2 PF15801.5 PIK53577.1 - 1.3 9.4 3.8 2.1 8.7 1.1 2.6 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding Nucleic_acid_bd PF13820.6 PIK53578.1 - 0.024 14.5 0.0 28 4.5 0.0 3.9 1 1 3 4 4 4 0 Putative nucleic acid-binding region Nmad3 PF18754.1 PIK53578.1 - 0.025 14.1 0.6 34 3.9 0.0 4.4 7 0 0 7 7 7 0 Nucleotide modification associated domain 3 L_HMGIC_fpl PF10242.9 PIK53578.1 - 0.05 13.8 9.1 84 3.3 0.1 6.0 1 1 6 7 7 7 0 Lipoma HMGIC fusion partner-like protein TFIIB PF00382.19 PIK53578.1 - 1.1 9.3 10.7 1e+02 3.0 0.2 6.3 2 1 6 8 8 8 0 Transcription factor TFIIB repeat DUF3499 PF12005.8 PIK53578.1 - 9.5 6.8 11.2 2.3e+02 2.4 0.0 5.8 1 1 6 7 7 7 0 Protein of unknown function (DUF3499) Sema PF01403.19 PIK53580.1 - 6.1e-35 120.9 1.7 1e-34 120.1 1.7 1.3 1 0 0 1 1 1 1 Sema domain TIG_plexin PF17960.1 PIK53580.1 - 1.3e-09 37.9 0.2 7.2e-09 35.5 0.1 2.3 2 0 0 2 2 2 1 TIG domain PSI PF01437.25 PIK53580.1 - 2e-08 34.6 11.3 6.4e-08 33.0 11.3 1.9 1 0 0 1 1 1 1 Plexin repeat Runt PF00853.19 PIK53580.1 - 0.056 13.0 0.1 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 Runt domain PSI_integrin PF17205.3 PIK53580.1 - 0.075 12.8 9.1 0.23 11.2 9.1 1.9 1 0 0 1 1 1 0 Integrin plexin domain MGC-24 PF05283.11 PIK53580.1 - 2.8 8.4 7.3 9.6 6.6 4.7 2.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Sema PF01403.19 PIK53581.1 - 1.5e-24 86.6 0.4 2.6e-24 85.8 0.4 1.3 1 0 0 1 1 1 1 Sema domain TIG_plexin PF17960.1 PIK53581.1 - 4.4e-15 55.4 0.2 1.8e-13 50.3 0.0 2.7 2 0 0 2 2 2 1 TIG domain TIG_2 PF18020.1 PIK53581.1 - 2.6e-13 50.4 0.9 4.9e-12 46.3 0.3 2.8 3 0 0 3 3 3 1 TIG domain found in plexin TIG PF01833.24 PIK53581.1 - 5.2e-11 42.5 7.7 0.00033 20.7 0.4 4.6 3 0 0 3 3 3 3 IPT/TIG domain PSI PF01437.25 PIK53581.1 - 1.3e-10 41.6 47.4 1.7e-07 31.7 11.0 3.9 3 0 0 3 3 3 3 Plexin repeat Plexin_cytopl PF08337.12 PIK53582.1 - 5.3e-19 68.3 0.4 6e-19 68.1 0.4 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain BSD PF03909.17 PIK53582.1 - 0.024 14.6 0.2 0.062 13.3 0.2 1.7 1 0 0 1 1 1 0 BSD domain F-box-like PF12937.7 PIK53583.1 - 3.9e-09 36.3 2.8 3.9e-09 36.3 2.8 2.0 2 0 0 2 2 2 1 F-box-like PI31_Prot_N PF11566.8 PIK53583.1 - 6e-09 35.9 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal F-box PF00646.33 PIK53583.1 - 1.3e-05 24.9 1.2 3.8e-05 23.4 1.2 1.9 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 PIK53583.1 - 0.00026 21.5 0.6 0.00052 20.5 0.6 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.5 PIK53583.1 - 0.00076 19.3 0.1 0.049 13.5 0.0 2.5 2 0 0 2 2 2 1 F-box PRANC PF09372.10 PIK53583.1 - 0.041 14.2 0.1 0.12 12.7 0.0 1.8 2 0 0 2 2 2 0 PRANC domain Synapsin_C PF02750.14 PIK53584.1 - 2.2e-12 46.9 0.1 1.7e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Synapsin, ATP binding domain Synapsin_C PF02750.14 PIK53585.1 - 2.2e-18 66.5 0.4 3.1e-18 66.0 0.4 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain DicB PF05358.11 PIK53585.1 - 9.3 6.5 19.0 63 3.8 0.1 6.4 4 2 1 5 5 5 0 DicB protein TIMP PF00965.17 PIK53586.1 - 6.7e-29 101.0 5.2 8.2e-29 100.7 5.2 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53586.1 - 4.7e-08 32.8 0.0 1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 PIK53587.1 - 4.6e-19 68.9 0.1 6.2e-19 68.5 0.1 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53587.1 - 4.9e-08 32.7 0.1 7.1e-08 32.2 0.1 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module NtA PF03146.15 PIK53587.1 - 0.015 15.2 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Agrin NtA domain Noelin-1 PF12308.8 PIK53587.1 - 0.065 13.2 0.5 0.14 12.2 0.4 1.4 1 1 0 1 1 1 0 Neurogenesis glycoprotein TIMP PF00965.17 PIK53588.1 - 2e-17 63.6 1.6 1.7e-16 60.6 1.6 1.9 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53588.1 - 0.016 15.0 0.0 0.058 13.2 0.0 1.9 2 0 0 2 2 2 0 UNC-6/NTR/C345C module KilA-N PF04383.13 PIK53588.1 - 0.049 13.5 0.1 5.5 6.9 0.0 2.2 1 1 1 2 2 2 0 KilA-N domain VWA_N2 PF16164.5 PIK53588.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 VWA N-terminal TIMP PF00965.17 PIK53589.1 - 2.5e-23 82.8 0.6 3.4e-23 82.4 0.6 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53589.1 - 6.7e-06 25.9 0.0 1.7e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 PIK53590.1 - 3.3e-24 85.7 1.0 5.2e-24 85.0 1.0 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Bee_toxin PF17454.2 PIK53590.1 - 0.098 12.7 0.4 0.35 11.0 0.4 1.9 1 0 0 1 1 1 0 Honey bee toxin TIMP PF00965.17 PIK53591.1 - 2.1e-14 53.7 5.1 1.2e-13 51.2 2.8 2.4 1 1 1 2 2 2 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53591.1 - 0.00031 20.5 0.0 0.00067 19.4 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 PIK53592.1 - 3e-30 105.4 3.5 3e-30 105.4 3.5 1.3 2 0 0 2 2 2 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53592.1 - 7.9e-12 44.9 0.4 1.4e-11 44.2 0.4 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module NtA PF03146.15 PIK53592.1 - 0.078 12.8 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Agrin NtA domain Alpha-amylase_C PF02806.18 PIK53593.1 - 1e-12 48.4 0.0 1e-11 45.1 0.0 2.2 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Pkinase_Tyr PF07714.17 PIK53594.1 - 2.8e-28 98.9 0.0 3.7e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK53594.1 - 5.9e-26 91.4 0.0 8.8e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53595.1 - 1.2e-39 136.1 0.0 1.7e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK53595.1 - 2.2e-07 30.6 0.0 4.4e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 PIK53596.1 - 6.9e-18 65.0 1.0 1.3e-16 60.8 1.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53596.1 - 3e-10 39.8 0.3 5.6e-09 35.7 0.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF615 PF04751.14 PIK53597.1 - 0.043 13.8 0.7 0.28 11.2 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF615) DUF2018 PF09442.10 PIK53598.1 - 0.063 14.2 0.7 2.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) DUF778 PF05608.12 PIK53598.1 - 0.18 12.1 0.1 0.22 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Hemopexin PF00045.19 PIK53600.1 - 3e-34 116.7 8.5 1.1e-12 47.7 0.0 4.1 4 0 0 4 4 4 4 Hemopexin MIEAP PF16026.5 PIK53601.1 - 0.096 12.9 5.8 0.13 12.4 5.8 1.3 1 0 0 1 1 1 0 Mitochondria-eating protein SirA PF10747.9 PIK53601.1 - 0.1 12.9 5.8 0.061 13.7 3.5 1.9 2 1 0 2 2 2 0 Sporulation inhibitor of replication protein SirA Ribosomal_S20p PF01649.18 PIK53601.1 - 0.25 12.0 0.1 0.25 12.0 0.1 3.3 1 1 1 3 3 3 0 Ribosomal protein S20 DUF922 PF06037.11 PIK53601.1 - 0.25 11.1 3.9 0.14 11.9 1.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF922) IZUMO PF15005.6 PIK53601.1 - 1.8 9.0 7.3 0.94 10.0 1.9 2.4 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Dpoe2NT PF12213.8 PIK53603.1 - 0.057 13.7 0.6 3 8.2 0.1 3.4 2 1 0 2 2 2 0 DNA polymerases epsilon N terminal CPG4 PF15481.6 PIK53604.1 - 0.12 13.0 2.3 0.16 12.6 0.2 2.2 3 1 0 3 3 3 0 Chondroitin proteoglycan 4 Exo_endo_phos_2 PF14529.6 PIK53605.1 - 4.7e-06 26.4 0.7 1.5e-05 24.8 0.4 2.1 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK53605.1 - 0.011 15.3 0.2 0.026 14.0 0.2 1.7 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family F_bP_aldolase PF01116.20 PIK53606.1 - 0.028 13.9 0.4 0.084 12.3 0.1 1.7 1 1 0 1 1 1 0 Fructose-bisphosphate aldolase class-II RHD3 PF05879.12 PIK53607.1 - 2.2e-05 22.9 0.0 2.2e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK53607.1 - 2.5e-05 24.4 4.9 0.0003 20.9 0.1 2.8 3 1 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 PIK53607.1 - 0.0012 18.9 0.0 0.0029 17.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 PIK53607.1 - 0.0021 17.4 0.2 0.0081 15.4 0.2 2.0 1 1 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AAA_28 PF13521.6 PIK53607.1 - 0.0093 16.2 0.0 0.15 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Cnn_1N PF07989.11 PIK53607.1 - 0.055 13.6 4.3 0.16 12.1 4.3 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 YabA PF06156.13 PIK53607.1 - 0.079 13.6 0.8 0.079 13.6 0.8 1.8 2 0 0 2 2 2 0 Initiation control protein YabA AAA_29 PF13555.6 PIK53607.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain BST2 PF16716.5 PIK53607.1 - 1.3 9.6 8.0 0.32 11.6 4.2 1.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 RVT_1 PF00078.27 PIK53609.1 - 2.5e-05 23.9 0.1 3.6e-05 23.4 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CPG4 PF15481.6 PIK53610.1 - 0.0037 17.9 0.9 0.051 14.2 0.1 2.2 2 0 0 2 2 2 1 Chondroitin proteoglycan 4 LRR_8 PF13855.6 PIK53613.1 - 1.2e-14 53.7 0.1 9.8e-08 31.7 0.0 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK53613.1 - 1.2e-06 28.7 1.1 0.089 13.2 1.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53613.1 - 2.1e-06 27.7 1.7 5.2e-06 26.4 1.7 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) NCD3G PF07562.14 PIK53613.1 - 0.0016 18.3 22.8 0.29 11.1 1.7 3.9 3 1 0 3 3 3 3 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 PIK53613.1 - 0.012 15.3 4.5 0.012 15.3 4.5 5.0 4 1 1 5 5 5 0 Putative ephrin-receptor like Orf78 PF06024.12 PIK53613.1 - 6.4 7.1 6.7 1.1 9.6 1.9 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Ion_trans PF00520.31 PIK53614.1 - 0.067 12.4 1.5 0.068 12.4 1.5 1.1 1 0 0 1 1 1 0 Ion transport protein MFS_1 PF07690.16 PIK53615.1 - 3.2e-10 39.5 21.5 6.2e-10 38.5 21.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3672 PF12421.8 PIK53616.1 - 0.081 12.8 1.3 35 4.3 0.1 3.8 2 2 3 5 5 5 0 Fibronectin type III protein DUF3439 PF11921.8 PIK53616.1 - 4.5 7.3 6.0 19 5.2 0.1 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 PIK53617.1 - 1.5e-48 165.5 0.0 2e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53617.1 - 3.2e-24 85.6 0.0 4.5e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK53617.1 - 0.0049 16.2 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 PIK53617.1 - 0.092 12.4 0.1 10 5.7 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 NACHT PF05729.12 PIK53618.1 - 3.9e-11 43.2 0.0 8.6e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK53618.1 - 0.0008 19.0 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK53618.1 - 0.033 14.5 0.0 0.087 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK53618.1 - 0.12 11.5 0.0 0.29 10.2 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DDE_Tnp_4 PF13359.6 PIK53619.1 - 2.1e-20 73.0 0.0 2.9e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 PIK53619.1 - 9.6e-05 22.1 0.0 0.00074 19.2 0.0 2.4 2 1 0 2 2 2 1 Transposase DDE domain NACHT PF05729.12 PIK53620.1 - 7e-10 39.1 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK53620.1 - 0.0012 18.4 0.0 0.012 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK53620.1 - 0.042 14.1 0.0 0.09 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK53620.1 - 0.099 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Exo_endo_phos_2 PF14529.6 PIK53623.1 - 4.5e-07 29.7 0.1 1.6e-06 28.0 0.1 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK53623.1 - 1.5e-05 24.6 0.3 5.5e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family NACHT PF05729.12 PIK53624.1 - 1.4e-11 44.6 0.0 3.4e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK53624.1 - 0.013 15.7 0.1 0.075 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK53624.1 - 0.015 14.9 0.0 0.056 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Aldo_ket_red PF00248.21 PIK53624.1 - 0.075 12.2 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Aldo/keto reductase family DUF3475 PF11961.8 PIK53625.1 - 0.076 13.1 0.7 14 5.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) Ten1 PF12658.7 PIK53625.1 - 0.098 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Telomere capping, CST complex subunit Ig_6 PF18452.1 PIK53626.1 - 0.088 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK53626.1 - 0.12 12.9 0.1 0.18 12.4 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK53627.1 - 0.0019 18.2 0.1 0.0056 16.7 0.0 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK53627.1 - 0.0067 17.0 0.0 4 8.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain AAA_25 PF13481.6 PIK53629.1 - 0.00022 20.9 0.0 0.00033 20.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK53629.1 - 0.00067 19.6 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK53629.1 - 0.02 15.1 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK53629.1 - 0.03 13.5 0.0 0.061 12.5 0.0 1.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 PIK53629.1 - 0.058 13.8 0.0 0.43 11.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Cnd1 PF12717.7 PIK53630.1 - 1.2e-08 35.2 0.5 9e-05 22.6 0.1 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK53630.1 - 3.9e-06 27.2 0.1 9.5e-06 25.9 0.0 1.7 1 1 0 1 1 1 1 HEAT repeats Arm PF00514.23 PIK53630.1 - 0.00061 19.7 0.1 2.7 8.2 0.0 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 PIK53630.1 - 0.0014 18.8 0.2 3.5 8.1 0.0 3.8 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.8 PIK53630.1 - 0.0017 18.0 0.0 1.1 8.8 0.0 3.0 1 1 1 2 2 2 1 CLASP N terminal Adaptin_N PF01602.20 PIK53630.1 - 0.0028 16.3 0.1 0.0036 15.9 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 PIK53630.1 - 0.014 16.0 0.0 0.027 15.1 0.0 1.6 1 1 0 1 1 1 0 Vacuolar 14 Fab1-binding region MMS19_N PF14500.6 PIK53630.1 - 0.045 13.3 0.1 3.8 7.0 0.0 2.8 2 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 PIK53631.1 - 6.5e-13 47.7 2.8 0.0013 18.9 0.0 4.0 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 PIK53631.1 - 1e-10 41.9 2.8 0.0001 22.6 0.2 2.4 1 1 1 2 2 2 2 HEAT repeats Arm PF00514.23 PIK53631.1 - 1.4e-10 40.8 0.4 0.0022 18.0 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 PIK53631.1 - 1.8e-07 31.3 1.6 9.3e-05 22.5 0.1 2.4 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK53631.1 - 7.7e-07 29.5 5.2 0.015 15.8 0.3 3.6 4 0 0 4 4 4 2 HEAT-like repeat Adaptin_N PF01602.20 PIK53631.1 - 0.00095 17.8 1.1 0.003 16.2 0.2 2.0 1 1 1 2 2 2 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 PIK53631.1 - 0.0049 17.4 0.1 0.045 14.4 0.0 2.3 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 PIK53631.1 - 0.0094 15.5 0.4 0.55 9.7 0.0 2.4 2 1 1 3 3 3 1 Tti2 family IFRD PF05004.13 PIK53631.1 - 0.015 14.4 1.5 0.41 9.7 0.1 2.2 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) KAP PF05804.12 PIK53631.1 - 0.019 13.2 0.1 0.021 13.0 0.1 1.1 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) DUF2019 PF09450.10 PIK53631.1 - 0.027 14.4 0.2 1.7 8.6 0.1 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2019) V-ATPase_H_N PF03224.14 PIK53631.1 - 0.067 12.5 0.0 0.092 12.0 0.0 1.3 1 1 0 1 1 1 0 V-ATPase subunit H Arm_2 PF04826.13 PIK53631.1 - 0.067 12.6 0.0 0.088 12.3 0.0 1.4 1 1 0 1 1 1 0 Armadillo-like Inp1 PF12634.7 PIK53632.1 - 0.093 12.7 0.0 1.7 8.7 0.0 2.6 2 2 1 3 3 3 0 Inheritance of peroxisomes protein 1 RVT_1 PF00078.27 PIK53637.1 - 1.1e-17 64.3 0.0 2.2e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK53637.1 - 6.3e-17 61.9 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53637.1 - 0.0014 18.7 1.7 0.0049 17.0 1.7 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK53637.1 - 0.0038 17.0 0.2 0.026 14.3 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK53637.1 - 0.081 13.0 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein 11 CREPT PF16566.5 PIK53637.1 - 0.35 11.0 2.1 3.8 7.7 0.5 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Fibrinogen_C PF00147.18 PIK53638.1 - 2.9e-28 99.2 0.4 4.7e-28 98.5 0.4 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53638.1 - 4.1e-09 36.3 12.7 4.1e-09 36.3 12.7 1.9 3 0 0 3 3 3 1 TILa domain Tme5_EGF_like PF09064.10 PIK53638.1 - 0.015 15.2 6.6 0.015 15.2 6.6 1.9 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like EGF PF00008.27 PIK53638.1 - 0.019 15.3 4.7 0.019 15.3 4.7 2.6 2 0 0 2 2 2 0 EGF-like domain VWC PF00093.18 PIK53638.1 - 1.2 9.5 18.5 10 6.5 18.5 2.2 1 1 0 1 1 1 0 von Willebrand factor type C domain EGF_3 PF12947.7 PIK53638.1 - 2.4 8.4 24.1 9.5e+02 0.1 24.1 2.6 1 1 0 1 1 1 0 EGF domain Fibrinogen_C PF00147.18 PIK53639.1 - 4.4e-37 128.0 13.7 2.8e-36 125.4 13.7 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK53640.1 - 3.4e-38 131.7 1.8 2.1e-18 67.0 0.1 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53640.1 - 2.8e-10 40.0 14.0 2.8e-10 40.0 14.0 3.5 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK53640.1 - 1.1e-05 25.6 9.6 1.1e-05 25.6 9.6 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK53640.1 - 0.00077 19.6 10.8 0.00077 19.6 10.8 4.0 2 2 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK53640.1 - 0.095 12.8 24.6 0.44 10.7 9.9 3.7 3 0 0 3 3 3 0 MSP1 EGF domain 1 Tme5_EGF_like PF09064.10 PIK53640.1 - 4 7.4 27.4 0.051 13.5 6.9 3.2 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Fibrinogen_C PF00147.18 PIK53641.1 - 8.5e-29 100.9 0.6 1.4e-28 100.2 0.6 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK53641.1 - 8.8e-10 38.4 12.4 8.8e-10 38.4 12.4 1.8 2 0 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK53641.1 - 0.00032 20.8 9.0 0.00032 20.8 9.0 2.6 1 1 1 2 2 2 1 EGF domain EGF_MSP1_1 PF12946.7 PIK53641.1 - 0.016 15.2 8.6 0.016 15.2 8.6 2.4 2 0 0 2 2 2 0 MSP1 EGF domain 1 VWC PF00093.18 PIK53641.1 - 0.051 13.9 17.9 0.22 11.8 17.7 2.0 1 1 1 2 2 2 0 von Willebrand factor type C domain EGF PF00008.27 PIK53641.1 - 0.061 13.6 4.6 0.061 13.6 4.6 2.5 2 0 0 2 2 2 0 EGF-like domain Fibrinogen_C PF00147.18 PIK53642.1 - 0.0006 19.7 0.0 0.00082 19.2 0.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK53643.1 - 5.7e-48 163.6 13.5 8.4e-48 163.1 13.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK53643.1 - 3.2e-05 24.1 11.7 3.2e-05 24.1 11.7 3.8 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK53643.1 - 0.0013 18.9 11.2 0.0013 18.9 11.2 5.0 4 2 0 4 4 4 1 EGF domain CD20 PF04103.15 PIK53644.1 - 0.0005 20.2 4.8 0.00071 19.7 4.8 1.2 1 0 0 1 1 1 1 CD20-like family DUF308 PF03729.13 PIK53644.1 - 0.014 15.7 4.4 0.029 14.7 4.4 1.7 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) DUF4064 PF13273.6 PIK53644.1 - 0.59 10.4 6.1 0.11 12.8 2.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) NUC153 PF08159.12 PIK53646.1 - 5.1e-12 45.4 0.5 9.2e-12 44.6 0.5 1.4 1 0 0 1 1 1 1 NUC153 domain BBS2_N PF14781.6 PIK53646.1 - 0.01 15.7 0.1 0.044 13.7 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal ANAPC4_WD40 PF12894.7 PIK53646.1 - 0.031 14.6 0.0 2.6 8.4 0.0 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ALMT PF11744.8 PIK53646.1 - 0.15 10.8 5.7 0.21 10.4 5.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 PIK53646.1 - 0.21 12.5 0.2 18 6.4 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat RRN3 PF05327.11 PIK53646.1 - 1.4 7.3 7.5 2 6.9 7.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sulfotransfer_1 PF00685.27 PIK53647.1 - 1.1e-29 103.7 0.2 1.9e-29 102.9 0.2 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK53647.1 - 5e-12 46.7 0.0 7.3e-07 29.8 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family GDP_Man_Dehyd PF16363.5 PIK53648.1 - 1.3e-17 64.2 0.0 1.2e-07 31.5 0.0 2.4 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 PIK53648.1 - 2.6e-16 59.8 0.0 4.2e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RPEL PF02755.15 PIK53649.1 - 8.6e-22 76.1 6.0 1.3e-07 31.0 0.0 3.9 4 0 0 4 4 4 3 RPEL repeat EB1 PF03271.17 PIK53650.1 - 3.7e-17 62.3 0.2 7.7e-17 61.3 0.2 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 PIK53650.1 - 4.5e-06 26.8 0.0 7.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain JAB PF01398.21 PIK53651.1 - 1.4e-17 63.7 0.1 2.6e-17 62.9 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SPRY PF00622.28 PIK53652.1 - 1.5e-14 54.1 0.0 3.3e-14 53.0 0.0 1.5 2 0 0 2 2 2 1 SPRY domain Sulfotransfer_1 PF00685.27 PIK53653.1 - 0.035 13.6 0.1 1.1 8.6 0.1 2.2 1 1 0 1 1 1 0 Sulfotransferase domain DUF4995 PF16386.5 PIK53653.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function TauD PF02668.16 PIK53654.1 - 3e-26 92.8 0.0 4.2e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK53654.1 - 0.045 14.4 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF971) CobT PF06213.12 PIK53654.1 - 0.81 9.0 16.4 1 8.7 16.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 PIK53654.1 - 1.8 6.5 36.6 2.2 6.3 36.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 PIK53654.1 - 3.2 5.8 24.6 3.9 5.6 24.6 1.1 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 PIK53654.1 - 4.6 5.6 17.2 5.8 5.2 17.2 1.1 1 0 0 1 1 1 0 Mpp10 protein 7tm_1 PF00001.21 PIK53655.1 - 7.3e-44 150.1 27.1 1.1e-43 149.5 27.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK53655.1 - 6.9e-07 29.3 14.8 1.2e-06 28.5 14.7 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK53655.1 - 0.07 12.5 27.9 0.11 11.8 27.9 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK53656.1 - 2e-22 79.8 2.8 2.4e-22 79.5 2.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK53656.1 - 1.7e-07 31.1 12.4 3e-07 30.3 12.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK53656.1 - 3.6e-05 23.3 4.7 0.00011 21.7 4.6 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.9 PIK53656.1 - 0.09 12.3 7.1 0.17 11.4 7.1 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc DUF3974 PF13120.6 PIK53656.1 - 0.12 12.5 1.3 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) DUF4834 PF16118.5 PIK53656.1 - 0.23 12.5 0.1 0.68 10.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Baculo_11_kDa PF06143.11 PIK53657.1 - 0.015 14.9 1.3 0.015 14.9 1.3 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family ECSCR PF15820.5 PIK53657.1 - 0.072 12.9 0.1 0.072 12.9 0.1 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Adeno_E3_CR2 PF02439.15 PIK53657.1 - 0.18 11.6 0.9 0.37 10.6 0.9 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 LRR_4 PF12799.7 PIK53659.1 - 6.4e-10 39.1 7.6 0.00016 22.0 2.1 4.3 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK53659.1 - 1.5e-09 37.5 4.7 2.7e-06 27.0 0.8 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 PIK53659.1 - 7.5e-06 25.6 0.5 3.3e-05 23.5 0.3 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK53659.1 - 0.02 14.9 1.7 1.4 9.2 0.0 3.4 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 PIK53659.1 - 0.68 10.7 8.3 38 5.4 0.1 5.0 4 1 1 5 5 5 0 Leucine Rich Repeat 7tm_2 PF00002.24 PIK53660.1 - 7.4e-61 205.5 19.0 1.2e-60 204.9 19.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Lectin_C PF00059.21 PIK53660.1 - 1.6e-13 51.3 4.3 8.1e-13 49.1 1.4 2.6 2 0 0 2 2 2 1 Lectin C-type domain GPS PF01825.21 PIK53660.1 - 5.6e-13 49.2 7.4 5.6e-13 49.2 7.4 2.9 4 0 0 4 4 4 1 GPCR proteolysis site, GPS, motif RT_RNaseH PF17917.1 PIK53661.1 - 2.8e-33 114.3 0.0 6.5e-33 113.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK53661.1 - 2e-31 108.0 0.0 4.9e-31 106.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK53661.1 - 2.6e-29 102.3 0.0 4.8e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK53661.1 - 1.9e-20 72.7 0.1 3.8e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK53661.1 - 1.1e-17 64.3 0.0 3.9e-17 62.5 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain NPP PF08384.10 PIK53661.1 - 0.0069 16.4 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region MLVIN_C PF18697.1 PIK53661.1 - 0.087 12.9 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Retrotran_gag_2 PF14223.6 PIK53662.1 - 0.097 12.3 0.1 1.3 8.6 0.0 2.3 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type 5_nucleotid_C PF02872.18 PIK53663.1 - 8.1e-09 35.9 0.0 2e-08 34.6 0.0 1.6 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK53663.1 - 1.2e-05 25.9 0.6 1.8e-05 25.4 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NAP PF00956.18 PIK53664.1 - 1.1e-103 346.1 7.7 1.8e-103 345.4 7.7 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Pex16 PF08610.10 PIK53666.1 - 4.6e-30 104.9 0.3 5.8e-30 104.6 0.3 1.1 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Glyco_transf_54 PF04666.13 PIK53667.1 - 4.5e-70 235.8 2.9 8.1e-70 235.0 2.9 1.4 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region RVT_1 PF00078.27 PIK53668.1 - 1.5e-10 40.9 0.0 3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF629 PF04780.12 PIK53668.1 - 0.0011 17.6 0.4 0.0014 17.2 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF629) RT_RNaseH_2 PF17919.1 PIK53669.1 - 4.8e-34 116.4 0.1 8.4e-34 115.6 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53669.1 - 8.6e-27 93.5 0.0 1.5e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GST_N PF02798.20 PIK53670.1 - 6.3e-11 42.5 0.0 1.1e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK53670.1 - 1.3e-08 35.1 0.0 2.1e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK53670.1 - 5e-07 29.9 0.0 1e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF1974 PF09317.11 PIK53670.1 - 0.028 14.0 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) GST_N_4 PF17172.4 PIK53670.1 - 0.14 12.9 0.0 0.4 11.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C PF00043.25 PIK53671.1 - 3.3e-07 30.4 0.0 4e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK53671.1 - 1e-05 25.6 0.0 1.4e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK53671.1 - 0.00041 20.3 0.1 0.0013 18.7 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain NACHT PF05729.12 PIK53673.1 - 3.7e-18 66.0 0.0 1e-17 64.5 0.0 1.8 2 0 0 2 2 2 1 NACHT domain V-set PF07686.17 PIK53673.1 - 3.7e-10 39.9 1.8 0.00073 19.7 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK53673.1 - 1.3e-06 28.4 0.8 0.02 15.0 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK53673.1 - 1.5e-05 25.5 6.3 0.69 10.6 0.1 5.0 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.6 PIK53673.1 - 5.3e-05 23.5 3.8 1.4 9.3 0.0 4.7 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK53673.1 - 0.00051 20.2 0.9 0.2 11.9 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin domain AAA_25 PF13481.6 PIK53673.1 - 0.042 13.4 0.0 0.09 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK53673.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RVT_1 PF00078.27 PIK53675.1 - 2.4e-05 23.9 0.0 3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK53676.1 - 9.4e-08 31.8 0.0 1.2e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S21 PF01165.20 PIK53677.1 - 3.2e-10 39.6 2.1 6.5e-10 38.6 2.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S21 RIO1 PF01163.22 PIK53678.1 - 1.5e-32 112.7 0.1 1.9e-32 112.4 0.1 1.1 1 0 0 1 1 1 1 RIO1 family RIO1 PF01163.22 PIK53679.1 - 4e-30 104.8 0.0 7.2e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 PIK53679.1 - 0.043 13.7 0.2 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 PIK53680.1 - 2.8e-29 100.7 7.8 1e-08 35.7 0.1 4.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53680.1 - 2.7e-07 30.8 0.1 0.69 10.2 0.0 3.5 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK53680.1 - 0.00013 21.9 0.1 0.16 11.8 0.0 2.1 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK53680.1 - 0.0015 17.6 0.0 0.061 12.3 0.0 2.4 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 PIK53680.1 - 0.059 12.7 0.2 2.9 7.1 0.1 2.2 2 0 0 2 2 2 0 WD40-like domain Bystin PF05291.11 PIK53682.1 - 1.5e-133 444.6 1.4 1.5e-133 444.6 1.4 1.6 2 0 0 2 2 2 1 Bystin TerB PF05099.13 PIK53682.1 - 0.017 15.0 0.1 0.049 13.6 0.1 1.7 1 0 0 1 1 1 0 Tellurite resistance protein TerB Glyco_transf_22 PF03901.17 PIK53683.1 - 2.1e-28 99.7 12.1 2.6e-28 99.4 12.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF5453 PF17534.2 PIK53683.1 - 0.061 13.3 1.2 0.11 12.4 1.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5453) DUF1772 PF08592.11 PIK53683.1 - 1.6 9.0 8.0 0.093 13.0 2.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) 7tm_1 PF00001.21 PIK53684.1 - 7.9e-27 94.2 9.0 9.7e-27 93.9 9.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK53684.1 - 8.8e-11 41.9 10.5 1.1e-10 41.7 10.5 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK53684.1 - 2e-08 34.0 8.5 2.4e-08 33.7 8.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK53684.1 - 0.00022 20.7 12.1 0.00028 20.4 12.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sugar_tr PF00083.24 PIK53685.1 - 1.4e-22 80.2 2.8 1.4e-22 80.2 2.8 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK53685.1 - 1.9e-21 76.4 5.9 1.9e-21 76.4 5.9 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Myc_target_1 PF15179.6 PIK53686.1 - 0.028 14.3 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 Myc target protein 1 N_methyl PF07963.12 PIK53686.1 - 3.4 7.4 4.9 5.8 6.7 4.9 1.3 1 0 0 1 1 1 0 Prokaryotic N-terminal methylation motif Ribonuc_L-PSP PF01042.21 PIK53687.1 - 1.3e-35 122.0 0.0 1.5e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP 7tm_1 PF00001.21 PIK53688.1 - 7.7e-25 87.7 4.0 1e-24 87.3 4.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) KR PF08659.10 PIK53689.1 - 1.3e-46 158.8 0.0 3e-46 157.6 0.0 1.7 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK53689.1 - 1.8e-15 56.9 0.0 3.8e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53689.1 - 2.7e-13 50.0 0.0 4.6e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thioesterase PF00975.20 PIK53689.1 - 3e-11 43.9 0.0 6.1e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 PIK53689.1 - 0.026 14.9 1.1 0.064 13.6 0.1 2.3 2 0 0 2 2 2 0 Phosphopantetheine attachment site Epimerase PF01370.21 PIK53689.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ldh_2 PF02615.14 PIK53690.1 - 4e-84 282.6 0.1 6e-61 206.4 0.1 2.0 1 1 1 2 2 2 2 Malate/L-lactate dehydrogenase Thioredoxin_8 PF13905.6 PIK53691.1 - 6.7e-25 87.3 0.0 9.4e-25 86.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 PIK53691.1 - 2.8e-09 36.9 0.0 3.6e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK53691.1 - 4.7e-07 29.6 0.0 5.8e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 PIK53691.1 - 7.8e-07 29.0 0.3 0.00025 21.0 0.2 2.2 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 PIK53691.1 - 3.5e-06 27.4 0.1 5.3e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain 7tm_1 PF00001.21 PIK53692.1 - 2.7e-31 108.9 9.3 3.6e-31 108.4 9.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CbtA PF09490.10 PIK53692.1 - 0.02 14.6 1.3 0.052 13.3 0.1 2.1 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) DOMON PF03351.17 PIK53693.1 - 4.2e-16 59.3 0.0 4e-11 43.2 0.0 2.6 2 0 0 2 2 2 2 DOMON domain Trypan_PARP PF05887.11 PIK53693.1 - 5e-05 23.3 29.0 5e-05 23.3 29.0 2.2 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) EGF PF00008.27 PIK53693.1 - 0.003 17.8 3.0 0.011 16.0 3.0 2.1 1 1 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 PIK53693.1 - 0.016 15.5 7.0 0.016 15.5 7.0 2.1 2 1 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 PIK53693.1 - 0.052 13.7 4.3 0.17 12.1 4.3 1.9 1 0 0 1 1 1 0 Laminin EGF domain Neisseria_TspB PF05616.13 PIK53693.1 - 0.98 7.8 8.8 0.92 7.9 6.3 2.0 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein WD40 PF00400.32 PIK53694.1 - 7.7e-28 96.2 12.7 4.6e-08 33.6 0.2 6.7 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53694.1 - 1.1e-14 54.5 5.0 0.00014 22.1 0.4 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK53694.1 - 0.018 14.0 0.1 0.24 10.3 0.0 2.5 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FAM183 PF14886.6 PIK53695.1 - 4.2e-35 120.8 2.2 5.4e-35 120.4 2.2 1.1 1 0 0 1 1 1 1 FAM183A and FAM183B related Ebp2 PF05890.12 PIK53696.1 - 2.3e-64 217.5 37.2 5.3e-64 216.4 37.2 1.5 1 1 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 LCIB_C_CA PF18599.1 PIK53696.1 - 0.69 9.2 2.9 0.76 9.0 1.3 1.9 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases ALMT PF11744.8 PIK53696.1 - 1.1 8.0 9.8 1.6 7.5 9.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Prominin PF05478.11 PIK53696.1 - 3.6 5.4 6.8 5 5.0 6.8 1.2 1 0 0 1 1 1 0 Prominin DEP PF00610.21 PIK53697.1 - 3.6e-14 52.6 0.0 1.7e-13 50.4 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 PIK53697.1 - 5.1e-05 23.1 0.2 0.062 13.1 0.2 2.5 2 0 0 2 2 2 2 RhoGAP domain Y_phosphatase PF00102.27 PIK53698.1 - 2.1e-139 462.8 0.5 1e-77 260.9 0.1 2.7 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK53698.1 - 1.1e-76 253.2 18.7 5.1e-13 49.2 0.1 10.0 9 0 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK53698.1 - 4.8e-13 49.5 32.6 0.11 13.1 0.0 10.3 9 2 0 10 10 10 5 Purple acid Phosphatase, N-terminal domain Y_phosphatase3 PF13350.6 PIK53698.1 - 3e-07 30.7 0.0 0.025 14.6 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.20 PIK53698.1 - 7.2e-07 29.1 0.0 0.019 14.8 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain fn3_2 PF16893.5 PIK53698.1 - 8.4e-06 25.8 0.2 18 5.6 0.0 5.7 5 0 0 5 5 5 0 Fibronectin type III domain PTPlike_phytase PF14566.6 PIK53698.1 - 0.00051 20.2 0.0 0.017 15.2 0.0 2.9 2 0 0 2 2 2 1 Inositol hexakisphosphate DUF3377 PF11857.8 PIK53698.1 - 0.014 15.3 0.1 0.039 13.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) fn3_4 PF16794.5 PIK53698.1 - 0.017 15.0 0.0 19 5.3 0.0 4.3 4 0 0 4 4 4 0 Fibronectin-III type domain TMEM154 PF15102.6 PIK53698.1 - 0.018 14.9 1.6 0.026 14.4 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family DUF5348 PF17295.2 PIK53698.1 - 0.021 14.7 0.0 7.2 6.6 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) DapB_N PF01113.20 PIK53698.1 - 0.032 14.4 0.7 5.1 7.2 0.0 3.4 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus zf-RING_12 PF17976.1 PIK53698.1 - 0.082 13.2 0.0 4.1 7.7 0.0 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF2280 PF10045.9 PIK53698.1 - 0.082 13.2 0.9 7.2 6.9 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) DUF1491 PF07372.12 PIK53698.1 - 0.16 12.4 0.0 13 6.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1491) FKBP_C PF00254.28 PIK53699.1 - 2.6e-26 91.8 0.0 7.7e-26 90.3 0.0 1.8 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 PIK53699.1 - 1.6e-16 60.7 0.0 1.6e-16 60.7 0.0 2.4 1 1 0 2 2 2 1 Nucleoplasmin-like domain GAGA_bind PF06217.12 PIK53699.1 - 0.13 12.6 4.7 0.17 12.1 4.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4604 PF15377.6 PIK53699.1 - 0.91 9.9 23.7 1.4 9.3 23.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Pox_Ag35 PF03286.14 PIK53699.1 - 1.9 8.3 26.3 2.6 7.8 26.0 1.4 1 1 0 1 1 1 0 Pox virus Ag35 surface protein PRA-PH PF01503.17 PIK53699.1 - 2.6 8.6 5.6 5.2 7.6 5.6 1.5 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF4746 PF15928.5 PIK53699.1 - 3 7.2 19.0 4.3 6.7 19.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 PIK53699.1 - 3 7.0 13.1 4.8 6.4 13.1 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Adeno_terminal PF02459.15 PIK53699.1 - 7.3 4.8 6.3 12 4.2 6.3 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Patched PF02460.18 PIK53700.1 - 1.9e-28 99.1 19.7 5.5e-23 81.0 20.7 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 PIK53700.1 - 1.1e-11 44.8 1.5 1.1e-11 44.8 1.5 2.3 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation UPF0561 PF10573.9 PIK53700.1 - 0.31 11.2 3.4 0.65 10.1 3.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 MMPL PF03176.15 PIK53700.1 - 1 8.2 18.1 0.04 12.9 1.2 2.2 2 0 0 2 2 2 0 MMPL family Patched PF02460.18 PIK53701.1 - 8.3e-11 40.7 0.2 1.1e-10 40.3 0.2 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK53701.1 - 1.7e-10 40.9 2.0 1.7e-10 40.9 2.0 2.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Tctex-1 PF03645.13 PIK53702.1 - 2.7e-22 78.9 0.1 3.8e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 Tctex-1 family ADK PF00406.22 PIK53704.1 - 2.7e-12 47.0 7.4 2.7e-10 40.5 0.0 4.0 5 0 0 5 5 5 2 Adenylate kinase AAA_17 PF13207.6 PIK53704.1 - 1e-05 26.0 4.4 0.028 14.9 0.3 3.8 3 0 0 3 3 3 2 AAA domain Hydin_ADK PF17213.3 PIK53704.1 - 0.00031 21.1 2.4 0.00031 21.1 2.4 4.1 3 1 0 3 3 3 1 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 PIK53704.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 PIK53704.1 - 0.25 11.5 2.3 0.43 10.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase DUF2408 PF10303.9 PIK53704.1 - 0.32 11.6 4.3 0.18 12.3 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) CH_2 PF06294.11 PIK53705.1 - 3.9e-10 39.7 0.1 1.3e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 CH-like domain in sperm protein Nuc_rec_co-act PF08815.10 PIK53705.1 - 0.088 12.7 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Nuclear receptor coactivator YlqD PF11068.8 PIK53706.1 - 0.012 16.0 0.3 0.012 16.0 0.3 2.3 2 0 0 2 2 2 0 YlqD protein Atg14 PF10186.9 PIK53706.1 - 0.066 12.3 14.5 0.49 9.4 5.1 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 PIK53706.1 - 0.077 12.6 15.9 2 7.9 8.4 2.4 2 1 1 3 3 3 0 Intermediate filament protein Spc7 PF08317.11 PIK53706.1 - 0.083 11.8 14.2 0.084 11.7 5.3 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1090 PF06476.12 PIK53706.1 - 0.12 12.5 11.0 0.16 12.1 1.5 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1090) DUF1664 PF07889.12 PIK53706.1 - 0.15 12.1 9.0 4.1 7.4 1.7 3.7 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF1640 PF07798.11 PIK53706.1 - 0.15 12.1 11.2 0.57 10.2 6.2 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Occludin_ELL PF07303.13 PIK53706.1 - 0.2 12.4 8.9 0.9 10.3 0.2 2.9 3 1 0 3 3 3 0 Occludin homology domain DASH_Spc19 PF08287.11 PIK53706.1 - 0.22 11.4 13.0 0.34 10.8 1.0 2.4 2 0 0 2 2 2 0 Spc19 DUF4363 PF14276.6 PIK53706.1 - 0.31 11.2 2.1 2.6 8.2 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) ABC_tran_CTD PF16326.5 PIK53706.1 - 0.47 10.7 9.1 0.56 10.5 0.4 3.3 3 1 1 4 4 3 0 ABC transporter C-terminal domain SlyX PF04102.12 PIK53706.1 - 0.6 10.8 11.6 0.25 12.0 2.2 3.8 2 2 2 4 4 4 0 SlyX DivIC PF04977.15 PIK53706.1 - 1.5 8.7 5.2 2.8 7.8 0.3 3.1 2 1 0 3 3 3 0 Septum formation initiator Snapin_Pallidin PF14712.6 PIK53706.1 - 1.7 9.2 6.2 4.1 7.9 0.2 3.2 2 1 0 2 2 2 0 Snapin/Pallidin YtxH PF12732.7 PIK53706.1 - 1.9 9.1 5.5 33 5.1 3.3 3.0 2 1 0 2 2 1 0 YtxH-like protein FAM76 PF16046.5 PIK53706.1 - 2.5 7.4 9.6 0.18 11.1 1.6 2.0 2 0 0 2 2 2 0 FAM76 protein bZIP_1 PF00170.21 PIK53706.1 - 3 8.0 9.0 0.56 10.3 0.7 3.3 4 0 0 4 4 4 0 bZIP transcription factor Syntaxin_2 PF14523.6 PIK53706.1 - 4.9 7.6 10.4 1.6 9.2 0.7 3.0 2 1 1 3 3 3 0 Syntaxin-like protein SBF PF01758.16 PIK53707.1 - 4.7e-27 94.9 13.3 4.7e-27 94.9 13.3 1.9 2 0 0 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK53707.1 - 0.019 13.4 6.8 0.044 12.2 1.3 2.8 2 1 1 3 3 3 0 Membrane transport protein SBF PF01758.16 PIK53708.1 - 2.7e-29 102.3 13.8 2.7e-29 102.3 13.8 1.9 3 0 0 3 3 3 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK53708.1 - 0.00091 17.7 8.1 0.024 13.1 4.4 2.7 2 1 0 2 2 2 2 Membrane transport protein DP-EP PF08985.11 PIK53708.1 - 0.048 13.8 1.2 0.11 12.6 1.2 1.6 1 0 0 1 1 1 0 DP-EP family Fil_haemagg_2 PF13332.6 PIK53708.1 - 0.062 13.4 2.1 0.13 12.4 2.1 1.4 1 0 0 1 1 1 0 Hemagglutinin repeat LapA_dom PF06305.11 PIK53708.1 - 0.15 11.9 2.0 0.96 9.3 0.0 3.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Invasin_D3 PF09134.10 PIK53708.1 - 0.17 12.2 3.6 0.11 12.8 1.1 1.9 2 0 0 2 2 2 0 Invasin, domain 3 ATP-synt_ab PF00006.25 PIK53709.1 - 1.3e-66 224.3 0.0 1.9e-66 223.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 PIK53709.1 - 1.9e-12 47.5 0.2 3.3e-12 46.8 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Creatinase_N_2 PF16189.5 PIK53710.1 - 4.2e-46 157.0 0.0 6.6e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 PIK53710.1 - 5.6e-44 150.3 0.0 9.3e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 PIK53710.1 - 1.5e-24 85.8 0.2 5.9e-24 83.9 0.2 2.1 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 PIK53710.1 - 3.3e-14 53.7 0.0 7.7e-12 46.0 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Kinesin PF00225.23 PIK53711.1 - 1.9e-93 313.0 5.5 1.9e-93 313.0 5.5 4.4 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 PIK53711.1 - 2.5e-08 34.0 0.2 2.5e-08 34.0 0.2 3.8 4 1 0 4 4 4 1 Microtubule binding DUF885 PF05960.11 PIK53711.1 - 0.0023 17.6 11.3 0.0023 17.6 11.3 2.2 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF885) DUF3834 PF12916.7 PIK53711.1 - 0.21 10.8 2.7 2.9 7.1 0.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3834) Prominin PF05478.11 PIK53713.1 - 0.0018 16.3 0.0 0.0024 15.9 0.0 1.1 1 0 0 1 1 1 1 Prominin DUF2353 PF09789.9 PIK53714.1 - 2e-104 349.4 30.5 2e-104 349.4 30.5 1.9 2 0 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) DUF3603 PF12227.8 PIK53714.1 - 2.1 7.6 11.5 1.5 8.0 2.2 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF3603) DM13 PF10517.9 PIK53715.1 - 2.4e-16 60.2 0.0 5.8e-07 30.0 0.0 3.4 2 1 0 2 2 2 2 Electron transfer DM13 DOMON PF03351.17 PIK53715.1 - 9.4e-09 35.6 0.0 2e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 DOMON domain Bact_lectin PF18483.1 PIK53715.1 - 0.1 12.6 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Bacterial lectin DM13 PF10517.9 PIK53716.1 - 1.4e-44 150.9 0.0 1.6e-24 86.5 0.0 2.4 2 0 0 2 2 2 2 Electron transfer DM13 DOMON PF03351.17 PIK53716.1 - 2.2e-15 57.0 0.0 4.8e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 DOMON domain Bact_lectin PF18483.1 PIK53716.1 - 0.0019 18.2 0.1 0.0055 16.8 0.1 1.7 2 0 0 2 2 2 1 Bacterial lectin Gaa1 PF04114.14 PIK53717.1 - 1.2e-103 347.8 8.1 1.4e-72 245.3 0.0 2.3 3 0 0 3 3 3 2 Gaa1-like, GPI transamidase component MIEAP PF16026.5 PIK53718.1 - 6e-37 127.8 0.1 1.1e-36 126.9 0.0 1.5 1 1 0 1 1 1 1 Mitochondria-eating protein rve_3 PF13683.6 PIK53718.1 - 2.3 8.1 4.6 15 5.5 0.1 3.5 3 1 1 4 4 4 0 Integrase core domain Longin PF13774.6 PIK53719.1 - 4.1e-11 42.8 0.0 1e-10 41.5 0.0 1.7 2 0 0 2 2 2 1 Regulated-SNARE-like domain N6-adenineMlase PF10237.9 PIK53720.1 - 9.1e-20 71.1 0.1 1.6e-19 70.3 0.1 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase DHHC PF01529.20 PIK53720.1 - 1.3 9.1 20.6 0.32 11.1 2.9 2.5 2 0 0 2 2 2 0 DHHC palmitoyltransferase LRR_8 PF13855.6 PIK53721.1 - 7.4e-35 118.5 37.2 5.7e-13 48.4 7.3 2.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK53721.1 - 2.4e-12 46.8 21.2 0.00028 21.2 8.0 3.1 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53721.1 - 5.6e-11 42.5 0.0 7.5e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK53721.1 - 1.1e-05 25.0 6.7 0.0025 17.4 1.2 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK53721.1 - 3.5e-05 23.8 14.3 1.6 9.6 0.3 4.9 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_8 PF13855.6 PIK53722.1 - 3.3e-67 222.1 50.2 7.2e-12 44.9 1.8 8.4 3 3 5 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 PIK53722.1 - 6.8e-33 113.4 0.2 3.3e-11 43.2 0.0 3.9 3 1 0 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK53722.1 - 2e-32 110.7 50.8 0.00062 20.1 1.4 9.4 6 2 1 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK53722.1 - 6.7e-20 71.3 22.0 3.2e-06 26.7 1.2 5.2 3 2 2 5 5 5 5 Leucine-rich repeat EGF PF00008.27 PIK53722.1 - 6.6e-18 64.7 72.3 9.4e-06 25.8 8.0 7.2 7 0 0 7 7 6 4 EGF-like domain hEGF PF12661.7 PIK53722.1 - 3.8e-13 49.5 68.6 0.00013 22.5 4.0 8.3 8 0 0 8 8 8 4 Human growth factor-like EGF LRRNT PF01462.18 PIK53722.1 - 7.4e-10 38.3 47.1 3.5e-05 23.3 1.8 6.5 7 0 0 7 7 7 3 Leucine rich repeat N-terminal domain LRRCT PF01463.24 PIK53722.1 - 2e-09 37.3 10.1 0.061 13.9 0.1 5.8 6 0 0 6 6 4 3 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 PIK53722.1 - 2.4e-07 30.4 41.3 0.41 11.4 0.5 13.6 13 2 0 13 13 12 3 Leucine Rich Repeat EGF_CA PF07645.15 PIK53722.1 - 0.00019 21.5 11.3 0.00019 21.5 11.3 7.9 5 1 2 7 7 7 3 Calcium-binding EGF domain EGF_3 PF12947.7 PIK53722.1 - 0.0047 17.1 2.6 0.0047 17.1 2.6 6.9 8 0 0 8 8 5 2 EGF domain Tetrabrachion PF11401.8 PIK53722.1 - 0.0077 16.2 0.1 3.5 7.7 0.0 3.0 2 0 0 2 2 2 1 Tetrabrachion cEGF PF12662.7 PIK53722.1 - 0.0079 16.1 1.7 0.0079 16.1 1.7 6.1 6 1 0 6 6 5 2 Complement Clr-like EGF-like LRR_2 PF07723.13 PIK53722.1 - 0.035 14.8 0.6 19 6.1 0.1 4.9 5 0 0 5 5 3 0 Leucine Rich Repeat TPKR_C2 PF16920.5 PIK53722.1 - 2.8 8.2 16.9 45 4.3 0.5 6.4 5 0 0 5 5 5 0 Tyrosine-protein kinase receptor C2 Ig-like domain FANCD2OS PF15124.6 PIK53724.1 - 0.018 15.2 0.1 0.046 13.9 0.0 1.7 2 0 0 2 2 2 0 FANCD2 opposite strand protein WD40 PF00400.32 PIK53725.1 - 9.7e-30 102.2 7.7 5e-07 30.3 0.8 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53725.1 - 1.3e-24 86.3 0.2 0.00066 19.9 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK53725.1 - 3e-11 43.6 0.3 1.3e-06 28.5 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK53725.1 - 3.1e-08 33.1 2.3 3.4e-05 23.1 0.7 3.0 1 1 1 3 3 3 2 Coatomer WD associated region PD40 PF07676.12 PIK53725.1 - 1.2e-05 25.1 0.0 0.0049 16.8 0.0 3.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 PIK53725.1 - 1.6e-05 23.2 0.5 0.00034 18.8 0.1 2.1 1 1 1 2 2 2 2 IKI3 family Cytochrom_D1 PF02239.16 PIK53725.1 - 0.00024 19.7 0.0 0.14 10.7 0.0 2.6 1 1 3 4 4 4 3 Cytochrome D1 heme domain WDCP PF15390.6 PIK53725.1 - 0.0028 16.1 0.6 0.0028 16.1 0.6 1.4 2 0 0 2 2 2 1 WD repeat and coiled-coil-containing protein family WD40_like PF17005.5 PIK53725.1 - 0.0086 15.4 0.1 3 7.1 0.1 3.0 2 1 0 3 3 3 1 WD40-like domain RAB3GAP2_N PF14655.6 PIK53725.1 - 0.041 13.1 0.0 4.2 6.5 0.0 2.6 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pyr_redox_2 PF07992.14 PIK53726.1 - 2e-61 207.8 0.1 3e-61 207.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK53726.1 - 2.7e-19 69.5 4.3 1.3e-15 57.7 0.5 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 PIK53726.1 - 9.7e-17 60.7 0.1 2.3e-16 59.5 0.1 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 PIK53726.1 - 1.2e-15 57.6 2.2 1.2e-12 47.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 PIK53726.1 - 5.3e-09 36.5 0.0 1.3e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 Reductase C-terminal HI0933_like PF03486.14 PIK53726.1 - 6.1e-09 35.1 0.2 0.071 11.8 0.0 3.1 3 0 0 3 3 3 3 HI0933-like protein Rieske_2 PF13806.6 PIK53726.1 - 1.5e-05 24.9 0.0 3.9e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain FAD_binding_2 PF00890.24 PIK53726.1 - 0.00086 18.5 0.7 0.0037 16.4 0.3 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 PIK53726.1 - 0.0067 16.6 0.6 0.0067 16.6 0.6 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 PIK53726.1 - 0.041 13.1 1.2 0.078 12.2 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Amino_oxidase PF01593.24 PIK53726.1 - 0.048 13.0 0.3 0.23 10.7 0.0 2.1 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase DAO PF01266.24 PIK53726.1 - 0.074 12.6 9.6 3.1 7.3 0.0 3.5 3 1 1 4 4 4 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK53726.1 - 0.095 12.7 0.4 36 4.3 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 PIK53726.1 - 3.1 6.5 4.5 8.4 5.1 0.1 2.4 3 0 0 3 3 3 0 Tryptophan halogenase Zona_pellucida PF00100.23 PIK53727.1 - 9.2e-22 78.1 4.2 1.1e-21 77.8 4.2 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Phage_Arf PF17585.2 PIK53727.1 - 0.18 11.8 0.0 0.43 10.6 0.0 1.6 2 0 0 2 2 2 0 Accessory recombination function protein Aerolysin PF01117.20 PIK53728.1 - 0.0006 19.1 0.5 0.0007 18.9 0.5 1.0 1 0 0 1 1 1 1 Aerolysin toxin Tfb4 PF03850.14 PIK53729.1 - 9.6e-94 313.9 0.2 1.2e-93 313.6 0.2 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Ssl1 PF04056.14 PIK53729.1 - 0.018 14.9 0.1 0.031 14.1 0.1 1.3 1 0 0 1 1 1 0 Ssl1-like T3SS_needle_F PF09392.10 PIK53729.1 - 0.023 14.9 1.5 0.041 14.1 0.0 2.1 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Pkinase PF00069.25 PIK53730.1 - 8.8e-68 228.5 0.1 1.2e-67 228.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53730.1 - 1.8e-46 158.5 0.2 3.4e-46 157.6 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RCC1 PF00415.18 PIK53730.1 - 2.8e-35 120.7 21.8 2.7e-09 37.5 0.1 8.1 7 1 1 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK53730.1 - 2.1e-21 75.2 32.5 5.2e-07 29.3 0.0 7.3 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat Haspin_kinase PF12330.8 PIK53730.1 - 0.0012 17.9 0.8 0.0021 17.1 0.8 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK53730.1 - 0.004 16.5 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 PIK53730.1 - 0.047 13.6 0.3 0.13 12.1 0.3 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK53730.1 - 0.049 12.4 0.0 0.13 11.0 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Bee_toxin PF17454.2 PIK53730.1 - 0.052 13.6 0.5 0.12 12.5 0.5 1.6 1 0 0 1 1 1 0 Honey bee toxin zf-C4 PF00105.18 PIK53731.1 - 4.7e-26 91.1 16.0 9.4e-26 90.1 16.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK53731.1 - 8.3e-14 51.6 0.6 2.1e-13 50.3 0.6 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF1712 PF08217.11 PIK53733.1 - 0.0066 15.0 0.4 0.0089 14.6 0.4 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Myosin_head PF00063.21 PIK53734.1 - 5.3e-194 646.2 0.1 6.3e-194 646.0 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 PIK53734.1 - 0.0022 18.2 0.0 0.0091 16.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK53734.1 - 0.013 15.9 0.0 0.088 13.2 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain CbiA PF01656.23 PIK53734.1 - 0.063 13.3 0.1 1.6 8.8 0.1 2.8 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain IQ PF00612.27 PIK53734.1 - 0.25 11.2 1.7 4 7.5 0.3 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif Vpu PF00558.19 PIK53735.1 - 0.095 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Vpu protein UQ_con PF00179.26 PIK53736.1 - 6.2e-43 145.8 0.4 7e-43 145.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK53736.1 - 5.5e-05 23.0 0.2 7.9e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 PIK53736.1 - 5.5e-05 23.4 0.3 7.2e-05 23.0 0.3 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK53736.1 - 0.00074 19.2 0.0 0.00087 19.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 PIK53736.1 - 0.03 13.9 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 PIK53737.1 - 2.6e-41 140.5 0.5 2.9e-41 140.4 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 PIK53737.1 - 6.2e-05 22.8 0.3 9.4e-05 22.3 0.3 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 PIK53737.1 - 6.3e-05 23.2 0.3 8e-05 22.9 0.3 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK53737.1 - 0.00078 19.2 0.0 0.00092 18.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 PIK53737.1 - 0.042 13.5 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RT_RNaseH_2 PF17919.1 PIK53738.1 - 1.7e-29 101.8 0.0 3.6e-29 100.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53738.1 - 9.6e-25 86.9 0.0 2.8e-24 85.4 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK53738.1 - 4.9e-23 81.6 0.0 8.5e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK53738.1 - 2.2e-19 69.3 1.9 2.2e-19 69.3 1.9 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK53738.1 - 8.6e-17 61.4 0.1 2.5e-16 59.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK53738.1 - 0.00021 21.4 0.9 0.00069 19.8 0.9 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK53738.1 - 0.0027 17.4 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain SprT-like PF10263.9 PIK53738.1 - 0.08 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 SprT-like family zf-C3HC4_3 PF13920.6 PIK53739.1 - 5.3e-07 29.4 11.9 1e-06 28.4 11.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK53739.1 - 3.1e-05 23.7 13.7 6.6e-05 22.7 13.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK53739.1 - 3.8e-05 23.5 14.4 8.8e-05 22.3 14.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK53739.1 - 6.9e-05 22.7 15.9 0.00077 19.4 16.2 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 PIK53739.1 - 0.0013 19.0 8.0 0.0039 17.5 8.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 PIK53739.1 - 0.0018 18.6 12.9 0.004 17.5 12.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK53739.1 - 0.0033 17.4 11.0 0.0083 16.1 11.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger BRE1 PF08647.11 PIK53739.1 - 0.0041 17.2 17.4 0.0041 17.2 17.4 10.3 5 3 6 11 11 8 1 BRE1 E3 ubiquitin ligase Prok-RING_4 PF14447.6 PIK53739.1 - 0.0058 16.5 8.1 0.012 15.4 8.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 PIK53739.1 - 0.0095 16.0 2.3 0.019 15.0 2.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 PIK53739.1 - 0.29 11.0 3.7 0.61 10.0 3.7 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 PIK53739.1 - 1.1 9.5 10.7 3.2 8.0 10.7 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zinc_ribbon_9 PF14369.6 PIK53739.1 - 2.2 8.6 7.8 0.86 9.9 2.6 2.5 2 0 0 2 2 2 0 zinc-ribbon FmiP_Thoc5 PF09766.9 PIK53740.1 - 2.9e-70 237.4 25.8 1.2e-38 133.4 0.0 3.9 3 1 0 3 3 3 2 Fms-interacting protein/Thoc5 RWD PF05773.22 PIK53740.1 - 0.5 10.7 0.1 0.5 10.7 0.1 2.8 4 0 0 4 4 4 0 RWD domain BLOC1_2 PF10046.9 PIK53740.1 - 0.92 9.8 14.0 0.27 11.6 1.0 3.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sds3 PF08598.11 PIK53742.1 - 3.9e-22 79.3 9.6 5.7e-22 78.8 9.6 1.3 1 0 0 1 1 1 1 Sds3-like MMR_HSR1_Xtn PF16897.5 PIK53743.1 - 8e-44 148.0 1.0 2.1e-43 146.7 1.0 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 PIK53743.1 - 3.5e-23 81.4 0.0 6e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 PIK53743.1 - 1.7e-19 70.0 0.0 4e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK53743.1 - 1.7e-10 40.6 0.0 1.5e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK53743.1 - 0.0026 17.9 0.1 3.1 7.8 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 PIK53743.1 - 0.007 15.4 0.2 0.02 13.9 0.1 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 PIK53743.1 - 0.013 15.1 0.0 5.4 6.5 0.0 3.5 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 PIK53743.1 - 0.14 12.7 0.1 0.75 10.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Pkinase PF00069.25 PIK53744.1 - 2e-74 250.3 0.0 2.5e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53744.1 - 2.7e-32 112.1 0.0 3.9e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK53744.1 - 1.5e-07 31.1 0.0 1.3e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK53744.1 - 5e-06 26.0 0.1 8.5e-06 25.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK53744.1 - 0.0016 17.5 0.0 0.0028 16.6 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 PIK53744.1 - 0.0024 17.5 0.1 0.0057 16.3 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 PIK53744.1 - 0.0035 16.2 0.0 0.006 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK53744.1 - 0.035 14.0 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YukC PF10140.9 PIK53744.1 - 0.089 11.6 0.1 0.15 10.9 0.1 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC SRR1 PF07985.12 PIK53745.1 - 1.6e-18 66.5 0.2 2.7e-18 65.7 0.2 1.4 1 0 0 1 1 1 1 SRR1 Exo5 PF09810.9 PIK53746.1 - 1.9e-53 182.3 17.4 8.2e-26 91.3 0.0 3.6 2 1 2 4 4 4 3 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 PIK53746.1 - 1.5e-06 28.4 0.0 2.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF647 PF04884.14 PIK53747.1 - 1.4e-98 329.4 3.3 2e-98 328.8 3.3 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Thiol_cytolysin PF01289.19 PIK53747.1 - 0.039 12.9 0.0 0.057 12.3 0.0 1.2 1 0 0 1 1 1 0 Thiol-activated cytolysin DUF4405 PF14358.6 PIK53747.1 - 1.8 9.2 6.2 44 4.7 0.7 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Rep-A_N PF04057.12 PIK53748.1 - 2.4e-27 94.9 0.0 2.3e-10 40.4 0.1 3.6 3 0 0 3 3 3 3 Replication factor-A protein 1, N-terminal domain Myb_DNA-bind_6 PF13921.6 PIK53749.1 - 0.013 15.7 0.1 0.048 13.9 0.0 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 PIK53749.1 - 0.17 12.1 0.1 0.48 10.7 0.1 1.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 PIK53749.1 - 0.22 11.9 0.0 0.22 11.9 0.0 3.0 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain AAA_23 PF13476.6 PIK53749.1 - 2.6 8.5 14.5 1 9.8 8.2 2.8 3 0 0 3 3 3 0 AAA domain EMC3_TMCO1 PF01956.16 PIK53749.1 - 8.7 6.1 8.0 0.81 9.4 1.0 2.7 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Helicase_C PF00271.31 PIK53750.1 - 7.1e-19 68.2 0.0 1.5e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 PIK53751.1 - 4e-64 216.5 2.0 7.6e-64 215.6 2.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.13 PIK53751.1 - 4e-21 75.1 7.1 4e-21 75.1 7.1 3.8 3 1 1 4 4 4 2 HSA DEAD PF00270.29 PIK53751.1 - 3.6e-08 33.4 0.1 4e-05 23.4 0.0 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 PIK53751.1 - 3.3e-06 27.2 0.0 3.3e-06 27.2 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DBINO PF13892.6 PIK53751.1 - 0.015 15.6 12.2 0.17 12.2 12.2 2.9 1 1 0 1 1 1 0 DNA-binding domain Phostensin_N PF13916.6 PIK53751.1 - 3 8.3 6.8 1.8 8.9 0.5 3.2 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal PGA_cap PF09587.10 PIK53752.1 - 3e-08 33.4 30.5 0.27 10.6 0.7 8.4 1 1 6 7 7 7 6 Bacterial capsule synthesis protein PGA_cap ChaC PF04752.12 PIK53752.1 - 0.22 11.6 6.4 1.7 8.6 0.2 3.7 4 1 0 4 4 4 0 ChaC-like protein GIDE PF12483.8 PIK53752.1 - 0.42 10.0 2.1 1.4e+02 1.8 0.0 4.4 1 1 3 6 6 6 0 E3 Ubiquitin ligase THB PF18362.1 PIK53752.1 - 3.8 7.2 11.6 1.8e+02 1.8 0.0 6.2 6 1 1 7 7 7 0 Tri-helix bundle domain DUF496 PF04363.12 PIK53752.1 - 4.3 7.4 7.7 21 5.2 0.5 3.3 2 1 1 4 4 4 0 Protein of unknown function (DUF496) Cwf_Cwc_15 PF04889.12 PIK53753.1 - 0.47 10.1 32.8 0.92 9.2 32.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 PIK53753.1 - 2 7.5 13.5 3.1 6.9 13.5 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein OB_NTP_bind PF07717.16 PIK53754.1 - 4.3e-23 81.5 0.0 1.8e-22 79.5 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK53754.1 - 4.3e-10 39.6 0.2 8.4e-10 38.7 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK53754.1 - 5.3e-08 33.2 0.1 6.9e-07 29.6 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 PIK53754.1 - 7.5e-05 23.1 0.1 0.00015 22.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK53754.1 - 0.00022 21.0 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK53754.1 - 0.00032 21.0 0.1 0.0011 19.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK53754.1 - 0.00084 19.4 0.0 0.43 10.6 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ATPase PF06745.13 PIK53754.1 - 0.0013 18.1 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 KaiC T2SSE PF00437.20 PIK53754.1 - 0.0023 17.0 0.0 0.0042 16.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 PIK53754.1 - 0.0093 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 PIK53754.1 - 0.039 13.4 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 PIK53754.1 - 0.13 12.8 0.0 0.39 11.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 PIK53754.1 - 1.9 9.0 9.3 96 3.4 9.3 2.6 1 1 0 1 1 1 0 AAA domain Ion_trans PF00520.31 PIK53756.1 - 3.5e-18 65.7 5.6 4.8e-18 65.3 5.6 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK53756.1 - 0.0086 16.0 3.0 0.0086 16.0 3.0 3.0 2 2 1 3 3 3 1 Ion channel Gemini_mov PF01708.16 PIK53756.1 - 0.16 11.7 1.3 0.49 10.2 0.2 2.3 2 0 0 2 2 2 0 Geminivirus putative movement protein eRF1_1 PF03463.15 PIK53757.1 - 2.6e-46 156.8 0.0 2.8e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 PIK53758.1 - 1e-23 84.0 0.0 1.8e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 PIK53758.1 - 1.5e-20 73.9 0.1 2.5e-20 73.1 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 WD40 PF00400.32 PIK53759.1 - 5.3e-48 160.0 24.1 2.4e-09 37.7 0.1 8.0 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53759.1 - 8.2e-22 77.3 2.6 4.9e-05 23.6 0.6 4.9 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 PIK53759.1 - 2.4e-13 50.4 0.2 4.4e-13 49.5 0.2 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 PIK53759.1 - 3.2e-07 29.6 0.0 0.02 13.8 0.0 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK53759.1 - 2.4e-05 24.3 0.0 1.2 8.9 0.0 3.0 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 PIK53759.1 - 6.7e-05 21.4 0.0 0.44 8.8 0.0 3.0 2 1 1 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 PIK53759.1 - 0.00013 20.8 0.3 1.5 7.4 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 PIK53759.1 - 0.00016 21.5 0.1 13 5.8 0.0 4.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 PIK53759.1 - 0.0014 18.0 0.0 1.7 7.9 0.0 3.2 3 0 0 3 3 3 1 WD40-like domain TRAP-delta PF05404.12 PIK53759.1 - 0.094 12.2 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) nos_propeller PF18764.1 PIK53759.1 - 0.19 11.7 0.0 6.2 6.8 0.0 3.4 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat Kinesin PF00225.23 PIK53760.1 - 2.3e-99 332.5 3.9 3.1e-99 332.0 0.4 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK53760.1 - 9.1e-24 84.1 0.0 2.4e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding YabA PF06156.13 PIK53760.1 - 0.089 13.4 5.0 3.2 8.5 0.9 3.2 2 0 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 PIK53760.1 - 0.23 11.9 9.6 0.57 10.7 4.5 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Rootletin PF15035.6 PIK53760.1 - 0.27 11.2 6.2 0.59 10.1 6.2 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 PIK53760.1 - 0.45 10.6 9.6 0.73 10.0 0.2 3.6 2 1 1 3 3 3 0 bZIP transcription factor PRKG1_interact PF15898.5 PIK53760.1 - 0.55 11.2 10.6 4.4 8.3 0.7 3.8 3 1 1 4 4 4 0 cGMP-dependent protein kinase interacting domain bZIP_2 PF07716.15 PIK53760.1 - 0.79 9.8 14.5 0.58 10.3 0.7 3.5 3 0 0 3 3 3 0 Basic region leucine zipper KIAA1430 PF13879.6 PIK53760.1 - 6.6 7.6 14.2 1.9e+02 2.9 13.3 2.9 1 1 1 2 2 2 0 KIAA1430 homologue bZIP_1 PF00170.21 PIK53761.1 - 0.084 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor GPCR_chapero_1 PF11904.8 PIK53762.1 - 5e-101 338.2 0.6 8.5e-101 337.4 0.6 1.4 1 0 0 1 1 1 1 GPCR-chaperone Ank PF00023.30 PIK53762.1 - 4.6e-07 30.0 0.0 1.1e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 PIK53762.1 - 5.6e-07 29.7 0.1 3.5e-06 27.2 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK53762.1 - 8.7e-07 29.4 0.0 2.2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK53762.1 - 9.9e-06 25.5 0.0 4.1e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 PIK53762.1 - 0.00027 21.4 0.0 0.00089 19.8 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) TBD PF12845.7 PIK53762.1 - 0.43 10.5 0.0 0.43 10.5 0.0 3.3 4 0 0 4 4 4 0 TBD domain RAP80_UIM PF18282.1 PIK53762.1 - 1.9 8.3 8.2 23 4.8 5.1 2.7 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif UIM PF02809.20 PIK53762.1 - 4.8 7.3 37.6 0.46 10.5 0.9 5.6 5 0 0 5 5 5 0 Ubiquitin interaction motif UCR_UQCRX_QCR9 PF05365.12 PIK53763.1 - 4.2e-21 74.6 0.2 4.7e-21 74.5 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GIY-YIG PF01541.24 PIK53764.1 - 9.8e-15 54.6 0.0 2e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.6 PIK53764.1 - 0.0076 16.5 2.7 0.013 15.7 2.7 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain T5orf172 PF10544.9 PIK53764.1 - 0.008 16.7 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 T5orf172 domain PHD PF00628.29 PIK53764.1 - 0.013 15.4 4.9 0.026 14.4 4.9 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 PIK53764.1 - 0.015 15.5 3.8 0.039 14.1 3.8 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.6 PIK53764.1 - 0.017 15.5 7.4 0.03 14.6 7.4 1.4 1 0 0 1 1 1 0 Ring finger domain Vps39_2 PF10367.9 PIK53764.1 - 0.028 14.9 0.9 0.048 14.1 0.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-HC5HC2H_2 PF13832.6 PIK53764.1 - 0.031 14.4 1.9 0.054 13.7 1.9 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain C1_2 PF03107.16 PIK53764.1 - 0.14 12.5 2.2 0.32 11.3 2.2 1.6 1 0 0 1 1 1 0 C1 domain RhoGAP PF00620.27 PIK53764.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 RhoGAP domain Prok-RING_1 PF14446.6 PIK53764.1 - 0.17 11.8 8.7 0.11 12.4 4.6 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 PIK53764.1 - 1.4 9.3 6.1 4.4 7.7 6.0 2.0 1 1 0 1 1 1 0 RING-like domain NIPSNAP PF07978.13 PIK53765.1 - 4.2e-23 81.5 0.4 1.1e-22 80.1 0.2 1.6 2 0 0 2 2 2 1 NIPSNAP Gal-3-0_sulfotr PF06990.11 PIK53766.1 - 1.1e-56 192.5 1.3 1.4e-56 192.2 1.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK53766.1 - 0.00016 21.7 3.0 0.0066 16.4 3.0 2.8 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK53766.1 - 0.0031 17.0 0.4 0.0071 15.8 0.4 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK53766.1 - 0.039 14.3 1.3 0.63 10.4 0.0 2.5 2 1 1 3 3 3 0 Sulfotransferase family Runt PF00853.19 PIK53766.1 - 0.042 13.4 0.1 0.086 12.4 0.1 1.4 1 0 0 1 1 1 0 Runt domain DENN PF02141.21 PIK53767.1 - 8.3e-34 117.2 1.1 2.2e-33 115.8 1.1 1.8 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 PIK53767.1 - 3e-19 69.5 1.2 1.1e-18 67.7 1.2 2.1 1 0 0 1 1 1 1 uDENN domain Nucleo_P87 PF07267.11 PIK53767.1 - 7 5.4 10.6 0.45 9.3 2.7 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 CASP_C PF08172.12 PIK53768.1 - 0.024 14.0 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 CASP C terminal SBF2 PF12335.8 PIK53768.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Myotubularin protein DUF4518 PF15008.6 PIK53768.1 - 0.092 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) AlcCBM31 PF11606.8 PIK53768.1 - 0.13 12.5 0.0 0.41 10.9 0.0 1.9 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein Agglutinin_C PF18021.1 PIK53768.1 - 0.13 12.8 0.2 0.34 11.5 0.2 1.6 1 0 0 1 1 1 0 Agglutinin C-terminal LRAT PF04970.13 PIK53769.1 - 5.2e-14 52.6 8.9 1.4e-07 31.9 1.8 2.9 2 1 0 2 2 2 2 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK53769.1 - 0.27 11.1 4.2 0.92 9.3 0.4 2.8 2 1 1 3 3 3 0 PPPDE putative peptidase domain LRAT PF04970.13 PIK53770.1 - 1.8e-15 57.3 1.5 6.5e-08 32.9 0.0 2.7 2 0 0 2 2 2 2 Lecithin retinol acyltransferase LRAT PF04970.13 PIK53771.1 - 1.2e-13 51.5 1.8 1.7e-09 38.0 0.2 2.5 2 1 0 2 2 2 2 Lecithin retinol acyltransferase Crust_neurohorm PF01147.17 PIK53771.1 - 0.083 12.7 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Peptidase_C97 PF05903.14 PIK53771.1 - 0.22 11.3 1.1 0.41 10.5 0.1 1.9 2 0 0 2 2 2 0 PPPDE putative peptidase domain Lactamase_B_2 PF12706.7 PIK53772.1 - 9.7e-31 106.8 0.0 1.3e-30 106.5 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 PIK53772.1 - 1.6e-13 50.9 0.0 2.2e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 PIK53772.1 - 0.00037 20.6 0.3 0.01 15.9 0.5 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Casc1_N PF15927.5 PIK53773.1 - 7.7e-42 143.3 13.1 9e-42 143.1 13.1 1.0 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus DUF3086 PF11285.8 PIK53773.1 - 0.0012 18.0 2.6 0.0015 17.7 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) SOG2 PF10428.9 PIK53773.1 - 0.038 13.2 0.2 0.06 12.5 0.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein MAP7 PF05672.11 PIK53773.1 - 1.9 8.2 15.5 2.5 7.8 15.5 1.4 1 1 0 1 1 1 0 MAP7 (E-MAP-115) family SDA1 PF05285.12 PIK53774.1 - 0.027 13.9 13.7 0.03 13.8 13.7 1.1 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 PIK53774.1 - 3.2 7.4 20.1 4.4 7.0 20.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Casc1 PF12366.8 PIK53775.1 - 8.2e-05 22.2 0.1 0.00011 21.9 0.1 1.3 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 Ribosomal_S13_N PF08069.12 PIK53776.1 - 1.7e-31 108.1 0.1 3.1e-31 107.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 PIK53776.1 - 1.3e-14 54.2 0.9 2.4e-14 53.3 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 DUF1057 PF06342.12 PIK53777.1 - 1.2e-16 60.6 0.0 1.5e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_1 PF00561.20 PIK53777.1 - 1.4e-10 41.2 0.1 4.3e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK53777.1 - 4.2e-09 36.0 0.0 1.9e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK53777.1 - 2.4e-07 31.6 0.0 4.2e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 PIK53777.1 - 0.0008 19.3 0.2 0.14 12.0 0.1 2.2 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_5 PF12695.7 PIK53777.1 - 0.03 14.1 0.1 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family PAS_11 PF14598.6 PIK53778.1 - 5.4e-18 65.2 0.1 4.5e-14 52.5 0.0 3.0 2 1 1 3 3 3 2 PAS domain HLH PF00010.26 PIK53778.1 - 2.2e-15 56.3 1.4 5.3e-15 55.1 1.4 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.12 PIK53778.1 - 1.1e-14 54.5 0.0 6.1e-12 45.7 0.0 2.6 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 PIK53778.1 - 4.2e-06 26.7 0.1 0.005 16.8 0.0 3.0 2 1 1 3 3 3 2 PAS fold PAS_9 PF13426.7 PIK53778.1 - 0.001 19.3 0.0 0.42 10.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain Fes1 PF08609.10 PIK53779.1 - 3.4e-05 24.6 2.1 3.4e-05 24.6 2.1 2.6 3 0 0 3 3 3 1 Nucleotide exchange factor Fes1 HEAT_EZ PF13513.6 PIK53779.1 - 0.003 18.0 0.2 0.035 14.6 0.0 2.9 3 1 1 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 PIK53779.1 - 0.0033 17.8 0.1 0.037 14.4 0.1 2.5 1 1 1 2 2 2 2 HEAT repeats V-ATPase_H_C PF11698.8 PIK53779.1 - 0.0035 17.4 5.7 0.41 10.8 0.1 3.1 2 1 0 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 PIK53779.1 - 0.021 14.9 2.9 0.022 14.8 0.6 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 PIK53779.1 - 0.023 14.6 1.2 0.11 12.4 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Dynactin_p22 PF07426.11 PIK53779.1 - 0.047 13.5 4.4 0.16 11.8 0.6 2.4 2 0 0 2 2 2 0 Dynactin subunit p22 DUF4404 PF14357.6 PIK53779.1 - 0.1 13.3 2.5 0.17 12.5 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) HEAT PF02985.22 PIK53779.1 - 2.3 8.7 7.1 1.9 9.0 0.1 3.6 5 0 0 5 5 5 0 HEAT repeat GNAT_acetyltr_2 PF13718.6 PIK53780.1 - 5.4e-103 343.3 0.3 1.1e-100 335.7 0.0 2.2 2 0 0 2 2 2 2 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 PIK53780.1 - 1.7e-71 240.7 8.0 2.5e-71 240.1 8.0 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 PIK53780.1 - 9.8e-07 28.8 0.0 2.8e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 Helicase Acetyltransf_1 PF00583.25 PIK53780.1 - 0.0031 17.7 0.0 0.0079 16.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 PIK53780.1 - 0.0042 17.5 0.0 0.013 15.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FlgT_M PF16539.5 PIK53780.1 - 0.22 11.6 1.7 0.52 10.4 1.7 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Helicase_RecD PF05127.14 PIK53781.1 - 4.8e-52 176.4 0.0 2.9e-51 173.8 0.0 2.1 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 PIK53781.1 - 3.2e-33 113.5 0.0 6.2e-33 112.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) DEAD PF00270.29 PIK53781.1 - 0.00034 20.4 0.0 0.00072 19.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 PIK53781.1 - 0.001 18.8 0.0 0.034 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK53781.1 - 0.0012 19.2 0.0 0.12 12.6 0.0 3.2 3 1 0 3 3 3 1 AAA domain LepB_GAP_N PF18172.1 PIK53781.1 - 0.021 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 LepB GAP domain N-terminal subdomain PHD PF00628.29 PIK53782.1 - 1.4e-09 37.7 8.5 2.8e-09 36.7 8.5 1.5 1 0 0 1 1 1 1 PHD-finger NAM-associated PF14303.6 PIK53782.1 - 0.017 15.9 10.1 0.027 15.2 0.2 3.0 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain PHD_2 PF13831.6 PIK53782.1 - 0.11 12.0 3.8 0.3 10.7 3.8 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.6 PIK53782.1 - 0.42 10.6 15.0 0.98 9.4 0.5 3.2 1 1 1 3 3 3 0 Putative zinc-RING and/or ribbon APG6_N PF17675.1 PIK53782.1 - 1.6 9.3 25.4 0.11 13.1 8.0 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region Metal_resist PF13801.6 PIK53782.1 - 2.1 8.6 8.6 0.15 12.3 1.7 2.4 3 0 0 3 3 3 0 Heavy-metal resistance zf-RING_2 PF13639.6 PIK53782.1 - 3.1 8.2 12.9 7.5 7.0 12.9 1.7 1 1 0 1 1 1 0 Ring finger domain Ureide_permease PF07168.11 PIK53782.1 - 9.9 4.8 10.0 18 4.0 0.0 2.9 3 0 0 3 3 3 0 Ureide permease NUP50 PF08911.11 PIK53783.1 - 2.2e-16 60.2 0.3 2.2e-16 60.2 0.3 3.2 3 2 1 4 4 4 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 PIK53783.1 - 7.2e-08 32.7 0.1 3.7e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 RanBP1 domain Zn-C2H2_12 PF18112.1 PIK53783.1 - 0.38 11.3 1.7 1.1 9.8 1.7 1.8 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain CENP-B_dimeris PF09026.10 PIK53783.1 - 2.2 8.7 6.9 11 6.5 0.2 2.9 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Ldl_recept_b PF00058.17 PIK53784.1 - 2e-13 50.5 0.9 4e-10 40.0 0.3 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK53784.1 - 0.1 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 PIK53785.1 - 5.3e-16 58.8 2.9 1.4e-06 28.6 0.0 4.6 4 0 0 4 4 4 4 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK53785.1 - 1.6e-07 31.5 7.3 1.6e-07 31.5 7.3 2.1 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK53785.1 - 0.0049 16.5 0.0 0.66 9.5 0.0 2.9 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region DUF3604 PF12228.8 PIK53785.1 - 0.14 10.6 0.1 0.18 10.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) EGF PF00008.27 PIK53785.1 - 1.2 9.6 7.1 1.4 9.3 5.3 2.2 1 1 1 2 2 2 0 EGF-like domain Sarcoglycan_1 PF04790.13 PIK53786.1 - 0.076 12.3 0.1 0.21 10.9 0.1 1.7 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein EphA2_TM PF14575.6 PIK53787.1 - 8.2e-07 29.8 0.4 2.2e-06 28.4 0.1 1.9 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.16 PIK53787.1 - 0.0012 17.7 0.0 0.002 17.0 0.0 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Shisa PF13908.6 PIK53787.1 - 0.0029 17.9 1.9 0.0075 16.5 1.9 1.9 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK53787.1 - 0.0032 17.4 0.6 0.0032 17.4 0.6 2.0 2 0 0 2 2 2 1 TMEM154 protein family NCU-G1 PF15065.6 PIK53787.1 - 0.005 15.9 0.9 0.012 14.6 0.9 1.6 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 Glycophorin_A PF01102.18 PIK53787.1 - 0.0057 16.9 0.2 0.012 15.8 0.2 1.5 1 0 0 1 1 1 1 Glycophorin A DAP10 PF07213.11 PIK53787.1 - 0.016 15.2 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 DAP10 membrane protein Orthoreo_P10 PF07204.11 PIK53787.1 - 0.022 14.7 1.1 0.04 13.9 1.1 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 ECSCR PF15820.5 PIK53787.1 - 0.037 13.9 0.2 0.069 13.0 0.2 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator LRRC37AB_C PF14914.6 PIK53787.1 - 0.048 13.6 1.2 0.076 12.9 0.0 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain NICE-1 PF15845.5 PIK53787.1 - 0.081 13.7 0.2 0.15 12.8 0.2 1.5 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family TMEM132D_C PF15706.5 PIK53787.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SKG6 PF08693.10 PIK53787.1 - 0.23 10.9 9.4 0.36 10.3 9.4 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Chordopox_A13L PF05961.11 PIK53787.1 - 0.77 10.0 4.7 0.27 11.5 0.6 2.5 2 1 0 2 2 2 0 Chordopoxvirus A13L protein DUF4051 PF13260.6 PIK53787.1 - 0.87 9.4 2.3 1.8 8.3 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) TMIE PF16038.5 PIK53787.1 - 1.4 8.8 5.1 3.5 7.6 5.1 1.6 1 0 0 1 1 1 0 TMIE protein Btz PF09405.10 PIK53788.1 - 6.6e-05 23.2 8.8 0.00024 21.3 8.8 2.0 1 1 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding Myotub-related PF06602.14 PIK53789.1 - 4.8e-113 377.7 0.7 3.1e-70 236.9 1.3 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain Hydrolase_4 PF12146.8 PIK53790.1 - 1.7e-15 56.9 0.0 2.4e-09 36.8 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK53790.1 - 3.1e-09 36.9 0.0 9.5e-05 22.2 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK53790.1 - 6.6e-07 30.2 0.0 2.3e-06 28.4 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 PIK53790.1 - 4.3e-06 26.5 0.0 9.1e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 PIK53790.1 - 4.7e-06 25.5 0.0 0.22 10.1 0.0 3.1 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 PIK53790.1 - 1.6e-05 24.9 0.0 2.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK53790.1 - 0.00036 20.1 0.2 0.0038 16.7 0.0 2.3 2 1 0 2 2 2 1 Prolyl oligopeptidase family PhoPQ_related PF10142.9 PIK53790.1 - 0.00052 18.8 0.0 0.00077 18.2 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DLH PF01738.18 PIK53790.1 - 0.0033 17.0 0.0 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF818 PF05677.12 PIK53790.1 - 0.0071 15.3 0.0 0.0085 15.1 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.11 PIK53790.1 - 0.0071 16.3 0.0 0.12 12.3 0.0 2.1 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 PIK53790.1 - 0.056 13.2 0.2 0.61 9.8 0.0 2.4 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 PIK53790.1 - 0.075 12.6 0.0 7.4 6.1 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.20 PIK53790.1 - 0.24 11.5 0.0 0.37 10.9 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain RRM_1 PF00076.22 PIK53791.1 - 0.00031 20.5 0.0 0.032 14.0 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK53791.1 - 0.039 13.8 0.0 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif MBOAT PF03062.19 PIK53792.1 - 1.5e-23 83.7 3.3 1.5e-23 83.7 3.3 1.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family NS3_envE PF02723.14 PIK53792.1 - 0.0077 16.3 0.8 0.027 14.5 0.8 1.9 1 0 0 1 1 1 1 Non-structural protein NS3/Small envelope protein E RT_RNaseH_2 PF17919.1 PIK53793.1 - 4.1e-35 119.8 0.0 6.6e-35 119.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK53793.1 - 5.7e-35 119.8 0.1 9.6e-35 119.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK53793.1 - 1.5e-29 103.1 0.0 2.3e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK53794.1 - 8.6e-22 77.6 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK53794.1 - 0.00018 21.2 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain AAA_16 PF13191.6 PIK53795.1 - 0.00052 20.4 0.0 0.00092 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK53795.1 - 0.0016 18.7 0.0 0.0038 17.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK53795.1 - 0.0048 16.8 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 PIK53795.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF4056 PF13265.6 PIK53795.1 - 0.033 13.5 0.1 0.045 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) AAA_5 PF07728.14 PIK53795.1 - 0.045 13.8 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF853 PF05872.12 PIK53795.1 - 0.049 12.2 0.0 0.068 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DAP3 PF10236.9 PIK53795.1 - 0.057 12.6 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 IstB_IS21 PF01695.17 PIK53795.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein SWIB PF02201.18 PIK53795.1 - 0.081 12.8 0.2 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 SWIB/MDM2 domain ABC_tran PF00005.27 PIK53795.1 - 0.1 13.1 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 PIK53795.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 PIK53795.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2791 PF10923.8 PIK53795.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Cytokin_check_N PF10407.9 PIK53795.1 - 0.16 12.0 0.3 31 4.6 0.1 3.3 2 1 1 3 3 3 0 Cdc14 phosphatase binding protein N-terminus DUF2075 PF09848.9 PIK53795.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TLD PF07534.16 PIK53796.1 - 0.031 14.5 0.8 0.71 10.1 0.8 2.5 1 1 0 1 1 1 0 TLD Clathrin PF00637.20 PIK53797.1 - 3.9e-200 655.8 41.6 1.7e-35 121.9 1.7 8.0 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 PIK53797.1 - 3.4e-50 166.0 0.5 3.6e-09 36.5 0.0 6.5 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 PIK53797.1 - 7e-32 109.1 0.9 4e-31 106.7 0.4 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 PIK53797.1 - 1.5e-12 46.7 1.4 4.8e-12 45.0 1.2 2.1 2 0 0 2 2 2 1 Clathrin, heavy-chain linker TPR_7 PF13176.6 PIK53797.1 - 1.3e-06 28.0 11.7 0.8 9.9 0.1 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 PIK53797.1 - 1.8e-06 27.3 0.5 0.00032 19.9 0.0 3.2 3 0 0 3 3 3 1 Coatomer WD associated region TPR_2 PF07719.17 PIK53797.1 - 0.024 14.7 15.0 1.7 8.9 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK53797.1 - 0.036 14.9 17.3 5.7 8.0 0.0 8.0 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK53797.1 - 0.14 12.0 15.7 0.55 10.1 0.0 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat Methyltransf_FA PF12248.8 PIK53798.1 - 1.1e-18 67.5 0.0 2.2e-18 66.5 0.0 1.5 2 0 0 2 2 2 1 Farnesoic acid 0-methyl transferase Lectin_C PF00059.21 PIK53798.1 - 5.8e-15 56.0 0.3 1.3e-06 29.1 0.0 2.5 2 0 0 2 2 2 2 Lectin C-type domain C8 PF08742.11 PIK53798.1 - 9.4e-11 42.0 1.4 9.4e-11 42.0 1.4 2.3 1 1 0 2 2 2 1 C8 domain UL45 PF05473.12 PIK53798.1 - 0.00037 20.2 0.1 0.0073 16.0 0.1 2.2 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like VWD PF00094.25 PIK53799.1 - 4.3e-31 108.3 0.2 4.9e-31 108.1 0.2 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain RGM_N PF06535.12 PIK53799.1 - 0.13 12.4 0.2 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus VWD PF00094.25 PIK53800.1 - 1.5e-17 64.3 3.9 6.6e-16 59.0 3.9 2.5 1 1 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK53800.1 - 1.1e-12 48.2 2.2 1.1e-12 48.2 2.2 2.8 2 0 0 2 2 2 1 C8 domain TILa PF12714.7 PIK53800.1 - 3e-11 43.1 8.3 3e-11 43.1 8.3 2.5 2 0 0 2 2 2 1 TILa domain TIL PF01826.17 PIK53800.1 - 3.4e-08 33.6 8.1 3.4e-08 33.6 8.1 3.2 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain DUF4817 PF16087.5 PIK53800.1 - 0.00022 21.0 0.1 0.35 10.7 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix domain (DUF4817) DUF4817 PF16087.5 PIK53801.1 - 0.12 12.2 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) zf-C3HC4_3 PF13920.6 PIK53802.1 - 4.4e-08 32.8 8.9 4.4e-08 32.8 8.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Armet PF10208.9 PIK53802.1 - 6.3e-05 22.9 7.6 0.037 14.0 0.1 2.9 2 1 1 3 3 3 2 Degradation arginine-rich protein for mis-folding SAP PF02037.27 PIK53802.1 - 0.015 15.1 0.1 4.1 7.3 0.0 2.8 2 0 0 2 2 2 0 SAP domain DIMCO_N PF16844.5 PIK53802.1 - 0.046 14.0 0.1 0.98 9.8 0.0 2.3 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal ATP11 PF06644.11 PIK53802.1 - 0.1 12.4 3.7 0.32 10.7 3.7 1.9 1 0 0 1 1 1 0 ATP11 protein Menin PF05053.13 PIK53802.1 - 0.3 9.4 10.7 1.8 6.8 5.2 2.1 2 0 0 2 2 2 0 Menin ADD_ATRX PF17981.1 PIK53802.1 - 0.54 10.2 8.4 0.15 12.0 1.4 2.7 2 0 0 2 2 2 0 Cysteine Rich ADD domain Glyco_hydro_63 PF03200.16 PIK53803.1 - 3.3e-12 45.9 6.9 6.4e-08 31.8 0.5 4.7 3 1 0 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain Ribosomal_L6e PF01159.19 PIK53804.1 - 1.3e-38 131.9 3.7 2.1e-38 131.3 0.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 PIK53804.1 - 2.5e-05 24.4 7.3 2.5e-05 24.4 7.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L6, N-terminal domain DegS PF05384.11 PIK53805.1 - 0.019 14.4 0.8 0.032 13.7 0.8 1.3 1 0 0 1 1 1 0 Sensor protein DegS DUF733 PF05306.11 PIK53805.1 - 0.027 14.8 0.6 0.066 13.5 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF733) THAP PF05485.12 PIK53806.1 - 0.0029 18.5 0.6 0.0075 17.2 0.1 1.9 2 0 0 2 2 2 1 THAP domain RVT_2 PF07727.14 PIK53807.1 - 5.7e-66 222.6 2.3 7.2e-66 222.3 2.3 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF432 PF04254.13 PIK53807.1 - 0.0079 16.4 0.2 0.012 15.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF432) adh_short_C2 PF13561.6 PIK53808.1 - 6e-33 114.4 0.0 7.7e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK53808.1 - 1.2e-17 64.0 0.0 1.7e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase NHL PF01436.21 PIK53810.1 - 3.8e-12 45.6 3.9 0.076 13.1 0.0 6.5 6 0 0 6 6 6 4 NHL repeat zf-RING_UBOX PF13445.6 PIK53810.1 - 3.9e-09 36.4 4.4 9.8e-09 35.1 4.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK53810.1 - 1.1e-08 34.8 6.2 3.3e-08 33.3 6.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK53810.1 - 4.5e-08 33.3 7.4 1.2e-07 31.9 7.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK53810.1 - 1.1e-07 31.5 7.6 2.4e-07 30.5 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK53810.1 - 2.7e-07 30.3 5.6 8e-07 28.8 5.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK53810.1 - 3e-06 27.3 7.5 3e-06 27.3 7.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK53810.1 - 4.6e-06 26.5 6.4 1.4e-05 25.0 6.4 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Filamin PF00630.19 PIK53810.1 - 6.9e-05 23.6 0.0 0.00024 21.9 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat Prok-RING_4 PF14447.6 PIK53810.1 - 0.00016 21.5 7.6 0.0018 18.1 7.8 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 SGL PF08450.12 PIK53810.1 - 0.00093 18.8 0.1 1 8.9 0.0 2.7 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region zf-RING_10 PF16685.5 PIK53810.1 - 0.014 15.5 4.7 0.046 13.8 4.7 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF5050 PF16472.5 PIK53810.1 - 0.033 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) SBBP PF06739.11 PIK53810.1 - 0.61 10.1 0.0 0.61 10.1 0.0 3.6 4 0 0 4 4 4 0 Beta-propeller repeat zf-rbx1 PF12678.7 PIK53810.1 - 1.3 9.3 7.7 6.5 7.1 7.8 2.1 1 1 1 2 2 2 0 RING-H2 zinc finger domain IP_trans PF02121.18 PIK53811.1 - 5.5e-103 343.8 0.3 6.2e-103 343.7 0.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Pex14_N PF04695.13 PIK53813.1 - 1.6 9.4 6.6 3.2 8.4 6.6 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sulfatase PF00884.23 PIK53814.1 - 2.1e-31 109.5 0.0 2.9e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphoesterase PF04185.14 PIK53814.1 - 0.0044 16.3 0.0 0.015 14.5 0.0 1.7 2 0 0 2 2 2 1 Phosphoesterase family DUF4994 PF16385.5 PIK53814.1 - 0.015 15.2 0.0 0.068 13.1 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function Sulfatase_C PF14707.6 PIK53814.1 - 0.089 13.5 0.1 0.27 12.0 0.1 1.9 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 PIK53814.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) mit_SMPDase PF14724.6 PIK53815.1 - 4.9e-22 77.8 4.1 1.1e-19 70.0 0.8 2.0 1 1 1 2 2 2 2 Mitochondrial-associated sphingomyelin phosphodiesterase mit_SMPDase PF14724.6 PIK53816.1 - 2.3e-62 211.1 0.0 5.7e-62 209.8 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase DUF3687 PF12459.8 PIK53816.1 - 0.036 13.6 1.8 0.089 12.3 1.8 1.6 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein NikR_C PF08753.11 PIK53816.1 - 0.12 12.5 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 NikR C terminal nickel binding domain RRM_1 PF00076.22 PIK53817.1 - 7.9e-41 137.7 0.1 2.6e-19 68.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK53817.1 - 5.7e-11 42.1 0.0 1.1e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif LSM_int_assoc PF16605.5 PIK53817.1 - 1.1e-07 31.8 2.6 7.9e-07 29.1 2.6 2.4 1 1 0 1 1 1 1 LSM-interacting associated unstructured Lsm_interact PF05391.11 PIK53817.1 - 1.6e-05 24.2 1.4 3.9e-05 23.0 1.4 1.7 1 0 0 1 1 1 1 Lsm interaction motif RRM_7 PF16367.5 PIK53817.1 - 0.0033 17.5 0.0 2.4 8.3 0.0 3.0 2 0 0 2 2 2 2 RNA recognition motif TPR_14 PF13428.6 PIK53817.1 - 0.0035 18.0 0.0 18 6.5 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Limkain-b1 PF11608.8 PIK53817.1 - 0.0094 16.0 0.0 0.052 13.6 0.0 2.3 2 0 0 2 2 2 1 Limkain b1 RRM_5 PF13893.6 PIK53817.1 - 0.03 13.9 0.0 0.59 9.7 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK53817.1 - 0.056 13.5 0.1 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Roughex PF06020.11 PIK53817.1 - 0.34 9.9 10.1 0.92 8.5 10.1 1.7 1 0 0 1 1 1 0 Drosophila roughex protein AP-5_subunit_s1 PF15001.6 PIK53817.1 - 6.3 6.7 8.6 20 5.1 8.6 1.9 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 PTS_2-RNA PF01885.16 PIK53818.1 - 2.3e-13 50.6 0.1 3.8e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family LRR_1 PF00560.33 PIK53818.1 - 0.0026 18.0 3.9 0.59 10.9 0.2 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_4 PF12799.7 PIK53818.1 - 0.015 15.7 8.0 0.12 12.9 1.1 4.0 1 1 3 4 4 4 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK53818.1 - 0.06 13.4 0.8 9 6.6 0.1 3.9 3 1 1 4 4 4 0 Leucine Rich repeat B9-C2 PF07162.11 PIK53819.1 - 2.7e-49 167.6 0.1 4.9e-49 166.8 0.1 1.4 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Rad51 PF08423.11 PIK53820.1 - 1.9e-27 96.2 0.0 2.5e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 DnaB_C PF03796.15 PIK53820.1 - 1.1e-06 28.2 0.0 3.3e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 PIK53820.1 - 2e-06 27.3 0.1 3.8e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 KaiC AAA_18 PF13238.6 PIK53820.1 - 0.011 16.3 0.0 0.017 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK53820.1 - 0.038 13.7 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 PIK53820.1 - 0.044 13.2 0.4 0.17 11.3 0.1 1.9 2 0 0 2 2 2 0 recA bacterial DNA recombination protein DUF1907 PF08925.11 PIK53821.1 - 1.2e-74 251.4 0.0 2.2e-74 250.4 0.0 1.4 1 1 0 1 1 1 1 Domain of Unknown Function (DUF1907) VWD PF00094.25 PIK53822.1 - 0.00044 20.5 1.1 0.0021 18.3 0.2 2.4 2 0 0 2 2 2 1 von Willebrand factor type D domain V-set PF07686.17 PIK53822.1 - 0.076 13.2 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin V-set domain EGF_2 PF07974.13 PIK53823.1 - 2.2e-25 88.7 124.3 4.8e-05 23.6 10.5 7.3 7 0 0 7 7 7 7 EGF-like domain EGF PF00008.27 PIK53823.1 - 1.4e-15 57.2 110.4 0.024 14.9 11.5 8.0 7 0 0 7 7 7 7 EGF-like domain hEGF PF12661.7 PIK53823.1 - 4.3e-10 39.8 112.9 0.017 15.7 7.5 9.5 11 0 0 11 11 11 7 Human growth factor-like EGF SLX9 PF15341.6 PIK53825.1 - 6.3e-26 91.3 18.4 6.3e-26 91.3 18.4 1.9 1 1 1 2 2 2 1 Ribosome biogenesis protein SLX9 DUF3141 PF11339.8 PIK53825.1 - 0.04 12.3 0.4 0.048 12.1 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DUF2203 PF09969.9 PIK53825.1 - 2.7 8.7 7.5 1.6 9.4 1.7 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DDHD PF02862.17 PIK53825.1 - 9.9 6.2 8.1 14 5.8 8.1 1.4 1 1 0 1 1 1 0 DDHD domain DUF2007 PF09413.10 PIK53826.1 - 0.07 13.3 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein zf-H2C2_2 PF13465.6 PIK53827.1 - 7.9e-08 32.4 27.0 1.4e-05 25.3 4.4 8.0 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK53827.1 - 0.00057 20.5 65.0 0.014 16.2 2.2 7.7 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK53827.1 - 0.00089 19.6 4.5 0.00089 19.6 4.5 8.0 9 0 0 9 9 9 4 Zinc finger, C2H2 type DUF2457 PF10446.9 PIK53827.1 - 0.0028 16.9 3.9 0.0028 16.9 3.9 4.3 3 1 1 4 4 4 1 Protein of unknown function (DUF2457) zf-C2HC_2 PF13913.6 PIK53827.1 - 0.012 15.5 2.1 0.012 15.5 2.1 6.5 8 0 0 8 8 8 0 zinc-finger of a C2HC-type TRAPPC-Trs85 PF12739.7 PIK53827.1 - 0.031 13.3 1.6 0.095 11.7 1.6 1.7 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit zf-Sec23_Sec24 PF04810.15 PIK53827.1 - 0.051 13.6 0.2 0.051 13.6 0.2 5.2 7 1 1 8 8 8 0 Sec23/Sec24 zinc finger zf-met PF12874.7 PIK53827.1 - 0.07 13.5 0.3 0.07 13.5 0.3 5.8 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK53827.1 - 0.68 10.0 41.7 0.098 12.7 1.3 6.6 6 0 0 6 6 6 0 C2H2-type zinc finger zf-Di19 PF05605.12 PIK53827.1 - 7 7.0 46.5 6 7.3 6.9 6.2 4 2 1 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.25 PIK53828.1 - 3.9e-66 223.1 0.1 4.9e-66 222.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53828.1 - 5.7e-35 120.8 0.0 6.9e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK53828.1 - 0.00035 20.0 0.5 0.00049 19.5 0.5 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK53828.1 - 0.0011 17.8 0.0 0.0019 17.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 PIK53828.1 - 0.0059 16.0 0.0 0.023 14.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 PIK53828.1 - 0.013 14.6 0.5 0.024 13.7 0.5 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 PIK53828.1 - 0.034 14.1 0.0 0.31 10.9 0.3 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 PIK53828.1 - 0.039 13.5 0.4 0.083 12.4 0.3 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 PIK53828.1 - 0.06 13.0 0.2 8.9 5.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 I-set PF07679.16 PIK53829.1 - 7.5e-16 58.0 0.0 1.6e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53829.1 - 2.9e-12 47.0 0.0 1.6e-11 44.6 0.0 2.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK53829.1 - 1.5e-09 37.9 0.0 5.1e-09 36.2 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK53829.1 - 1.8e-08 34.6 0.0 5.7e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK53829.1 - 0.003 17.6 0.0 0.019 15.0 0.0 2.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK53829.1 - 0.046 13.9 0.0 0.28 11.4 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin V-set domain I-set PF07679.16 PIK53830.1 - 2.6e-19 69.1 0.0 4.5e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53830.1 - 6.5e-11 42.7 0.1 3.6e-10 40.3 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK53830.1 - 1.9e-07 31.1 0.3 1.1e-06 28.7 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK53830.1 - 6.1e-07 29.6 0.3 2.8e-06 27.5 0.0 2.2 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK53830.1 - 6.5e-06 26.4 0.0 1.7e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK53830.1 - 0.0033 16.9 0.0 0.007 15.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK53831.1 - 2.5e-235 761.4 2.4 6.4e-26 90.3 0.1 11.0 11 0 0 11 11 11 10 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK53831.1 - 1.1e-143 468.1 0.0 2.7e-13 50.3 0.0 11.3 10 0 0 10 10 10 10 Immunoglobulin domain ig PF00047.25 PIK53831.1 - 1.8e-93 306.9 5.7 3.1e-11 43.3 0.1 11.0 10 0 0 10 10 10 10 Immunoglobulin domain Ig_2 PF13895.6 PIK53831.1 - 9.8e-85 279.0 0.0 7.4e-09 35.8 0.0 10.5 10 0 0 10 10 10 10 Immunoglobulin domain Pkinase PF00069.25 PIK53831.1 - 4.4e-71 239.3 0.0 6.7e-71 238.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK53831.1 - 3.8e-38 130.0 18.2 5.6e-06 26.5 0.0 15.8 10 7 0 10 10 10 8 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 PIK53831.1 - 8.8e-35 120.2 0.0 1.4e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 PIK53831.1 - 1.7e-28 98.5 0.7 0.027 14.6 0.0 10.8 10 1 0 10 10 10 7 CD80-like C2-set immunoglobulin domain fn3 PF00041.21 PIK53831.1 - 1.1e-14 54.5 0.6 8.4e-13 48.5 0.1 3.3 3 0 0 3 3 2 1 Fibronectin type III domain Receptor_2B4 PF11465.8 PIK53831.1 - 6.1e-13 48.9 0.6 0.089 13.0 0.0 8.3 9 0 0 9 9 9 2 Natural killer cell receptor 2B4 Ig_6 PF18452.1 PIK53831.1 - 3e-12 45.9 0.0 0.069 12.7 0.0 7.1 7 0 0 7 7 7 2 Immunoglobulin domain Izumo-Ig PF16706.5 PIK53831.1 - 9e-12 44.9 4.4 0.71 10.0 0.0 8.8 9 0 0 9 9 9 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK53831.1 - 3.4e-09 37.0 9.6 0.63 10.5 0.6 9.1 9 0 0 9 9 9 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 PIK53831.1 - 5.5e-09 36.0 0.0 1.7 8.8 0.0 7.4 8 1 0 9 9 8 3 C17orf99 Ig domain Ig_4 PF16680.5 PIK53831.1 - 8.8e-09 35.5 5.7 0.62 10.4 0.1 9.2 10 0 0 10 10 9 1 T-cell surface glycoprotein CD3 delta chain BiPBP_C PF06832.12 PIK53831.1 - 6.4e-06 26.1 0.0 2.8 8.1 0.0 6.0 7 0 0 7 7 7 1 Penicillin-Binding Protein C-terminus Family Pur_ac_phosph_N PF16656.5 PIK53831.1 - 0.0011 19.5 1.0 0.008 16.7 0.4 2.9 2 1 0 2 2 1 1 Purple acid Phosphatase, N-terminal domain Kdo PF06293.14 PIK53831.1 - 0.0056 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK53831.1 - 0.0068 15.7 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like PKD_3 PF16820.5 PIK53831.1 - 0.007 16.1 0.1 56 3.6 0.0 4.9 4 0 0 4 4 4 0 PKD-like domain PhoD_N PF16655.5 PIK53831.1 - 0.064 13.8 0.0 0.89 10.1 0.0 2.8 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain Amidase_6 PF12671.7 PIK53831.1 - 0.096 12.8 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Putative amidase domain zf-C2H2_4 PF13894.6 PIK53832.1 - 2.2e-11 43.6 51.2 0.00053 20.6 2.5 7.2 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK53832.1 - 3.7e-11 42.8 52.0 5.4e-05 23.4 3.7 7.4 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK53832.1 - 5.1e-11 42.5 46.2 4.3e-06 26.9 4.8 7.6 8 0 0 8 8 8 4 Zinc-finger double domain zf-Di19 PF05605.12 PIK53832.1 - 1.5e-08 34.8 29.8 3.2e-06 27.3 5.4 4.6 3 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 PIK53832.1 - 0.00035 20.8 29.7 0.0042 17.4 2.0 6.0 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK53832.1 - 0.0091 16.3 30.7 0.045 14.0 0.6 5.6 6 0 0 6 6 5 3 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK53832.1 - 0.015 15.3 2.7 0.015 15.3 2.7 6.4 4 2 3 7 7 7 0 BED zinc finger zf-C2H2_6 PF13912.6 PIK53832.1 - 0.14 12.2 41.4 0.33 11.0 2.3 6.8 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK53832.1 - 0.36 11.2 34.9 0.22 11.9 1.4 5.9 2 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 PIK53832.1 - 0.76 9.9 20.1 6.6 6.9 5.0 5.1 5 1 0 5 5 5 0 Zinc ribbon domain zf-C2HE PF16278.5 PIK53832.1 - 1.4 9.4 19.2 2.7 8.5 1.2 4.8 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger C1_1 PF00130.22 PIK53832.1 - 2.1 8.3 28.8 0.73 9.8 3.2 5.6 4 2 1 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cas_CXXC_CXXC PF09706.10 PIK53832.1 - 2.2 8.6 0.0 2.2 8.6 0.0 4.6 4 1 1 5 5 4 0 CRISPR-associated protein (Cas_CXXC_CXXC) GAGA PF09237.11 PIK53832.1 - 2.8 7.8 5.5 1.3 8.9 0.2 2.7 2 1 1 3 3 2 0 GAGA factor zinc_ribbon_15 PF17032.5 PIK53832.1 - 3.4 8.5 22.6 0.57 11.0 2.0 4.1 3 1 2 5 5 4 0 zinc-ribbon family DUF3268 PF11672.8 PIK53832.1 - 4.7 7.6 13.9 1.7 9.0 0.6 3.1 2 1 1 3 3 3 0 zinc-finger-containing domain PolC_DP2 PF03833.13 PIK53832.1 - 4.9 4.9 7.8 8.3 4.1 7.8 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 TRAF6_Z2 PF18048.1 PIK53832.1 - 8.8 6.5 10.0 1.4 9.0 5.4 2.1 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-CCHC_2 PF13696.6 PIK53832.1 - 10 6.1 7.6 16 5.4 0.4 3.6 3 0 0 3 3 3 0 Zinc knuckle zf-H2C2_2 PF13465.6 PIK53833.1 - 5.9e-12 45.4 43.2 1.1e-05 25.6 6.5 6.7 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK53833.1 - 1.9e-09 37.5 53.5 0.0091 16.8 0.5 7.2 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK53833.1 - 1e-06 28.8 60.4 0.0026 18.1 4.3 7.3 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK53833.1 - 0.00011 22.5 6.9 0.00011 22.5 6.9 5.1 4 1 2 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK53833.1 - 0.0074 16.3 1.3 0.0074 16.3 1.3 5.8 5 1 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK53833.1 - 0.23 11.8 0.1 0.23 11.8 0.1 5.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 PIK53833.1 - 9.2 6.2 7.9 26 4.7 0.6 3.7 1 1 2 3 3 3 0 GAGA factor Peptidase_M20 PF01546.28 PIK53834.1 - 8.8e-12 45.2 0.0 1.2e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 PIK53834.1 - 9.8e-11 41.5 0.0 1.8e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain zf-C2H2_4 PF13894.6 PIK53835.1 - 5.1e-08 33.1 59.3 0.0054 17.5 4.8 7.7 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK53835.1 - 8.9e-08 32.2 13.0 1.1e-05 25.7 0.9 7.4 7 1 0 7 7 7 2 Zinc-finger double domain zf-Di19 PF05605.12 PIK53835.1 - 6.3e-06 26.4 22.1 4e-05 23.8 4.5 5.4 5 1 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 PIK53835.1 - 0.00046 20.5 62.3 0.005 17.2 6.2 7.4 8 0 0 8 8 8 3 Zinc finger, C2H2 type XPA_N PF01286.18 PIK53835.1 - 0.02 14.9 0.0 0.02 14.9 0.0 4.8 6 0 0 6 6 6 0 XPA protein N-terminal Cript PF10235.9 PIK53835.1 - 0.031 14.8 23.1 0.11 13.0 3.5 4.0 3 1 1 4 4 4 0 Microtubule-associated protein CRIPT TRAF6_Z2 PF18048.1 PIK53835.1 - 1.3 9.2 11.6 0.89 9.7 5.1 2.8 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 NDUF_B12 PF08122.12 PIK53836.1 - 9.7e-20 70.4 1.1 1.3e-19 70.0 1.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family UPF0302 PF08864.10 PIK53837.1 - 6.8e-10 38.9 6.6 3.5 7.7 0.1 7.4 2 2 7 9 9 9 6 UPF0302 domain Ufm1 PF03671.14 PIK53837.1 - 3.8e-07 30.1 0.0 77 3.5 0.0 7.5 2 2 8 10 10 10 0 Ubiquitin fold modifier 1 protein Inhibitor_I69 PF13734.6 PIK53837.1 - 4.1e-07 30.4 8.3 85 3.7 0.0 9.5 2 2 11 13 13 13 0 Spi protease inhibitor RVT_1 PF00078.27 PIK53838.1 - 1.4e-30 106.4 0.3 5.3e-30 104.6 0.1 2.0 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PP_kinase PF02503.17 PIK53838.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase middle domain EamA PF00892.20 PIK53839.1 - 1.2e-14 54.7 37.3 4.3e-08 33.4 12.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF5316 PF17247.2 PIK53839.1 - 0.0078 16.2 2.0 0.015 15.3 0.0 2.6 3 0 0 3 3 3 1 Family of unknown function (DUF5316) Pkinase_Tyr PF07714.17 PIK53840.1 - 8.2e-88 294.0 0.0 1.2e-87 293.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 PIK53840.1 - 1.7e-50 169.8 3.0 2.3e-27 95.4 0.1 2.4 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 PIK53840.1 - 3.6e-38 131.5 0.0 5.3e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 PIK53840.1 - 2.5e-33 115.1 156.1 2e-21 76.4 44.7 6.3 3 2 3 6 6 6 5 Furin-like cysteine rich region GF_recep_IV PF14843.6 PIK53840.1 - 1.1e-30 106.1 148.0 5.3e-15 55.4 30.5 6.0 3 3 2 5 5 5 4 Growth factor receptor domain IV Haspin_kinase PF12330.8 PIK53840.1 - 0.016 14.2 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 PIK53840.1 - 0.067 12.5 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 PIK53840.1 - 0.073 12.4 0.2 0.13 11.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK53840.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Syndecan PF01034.20 PIK53840.1 - 0.55 10.2 1.7 1.3 9.0 1.2 1.8 2 0 0 2 2 2 0 Syndecan domain Pentapeptide_4 PF13599.6 PIK53842.1 - 0.0024 18.0 5.0 0.79 9.9 0.1 2.8 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 PIK53842.1 - 0.34 10.6 1.9 27 4.5 0.1 3.1 2 1 1 3 3 3 0 Pentapeptide repeats (8 copies) DUF3425 PF11905.8 PIK53842.1 - 1.5 8.8 7.0 6.2 6.8 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3425) Kelch_1 PF01344.25 PIK53843.1 - 3.4e-30 103.4 5.8 4.5e-12 45.4 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 PIK53843.1 - 1.2e-15 57.1 3.2 6.2e-06 26.3 0.0 3.3 2 1 1 3 3 3 3 Kelch motif Kelch_4 PF13418.6 PIK53843.1 - 1.9e-12 46.9 4.2 0.00016 21.6 0.0 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK53843.1 - 5.7e-12 45.1 2.6 6.8e-05 22.7 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 PIK53843.1 - 3e-09 36.9 3.3 1.2e-05 25.4 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK53843.1 - 7.8e-06 25.7 0.9 0.046 13.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif DUF4746 PF15928.5 PIK53843.1 - 1.3 8.3 6.7 1.7 8.0 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Kelch_1 PF01344.25 PIK53844.1 - 7.2e-33 111.9 8.0 2.1e-15 56.0 0.1 3.3 3 0 0 3 3 3 3 Kelch motif BTB PF00651.31 PIK53844.1 - 7.6e-30 103.4 0.3 1.7e-29 102.3 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 PIK53844.1 - 4.2e-19 68.6 0.6 2e-18 66.3 0.5 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 PIK53844.1 - 3.3e-18 65.3 3.8 5.8e-10 39.1 0.0 3.4 1 1 2 3 3 3 3 Kelch motif Kelch_2 PF07646.15 PIK53844.1 - 4.1e-14 51.9 3.2 3.9e-08 33.0 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 PIK53844.1 - 7.6e-10 38.8 2.9 1.2e-06 28.7 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK53844.1 - 2.4e-05 24.2 1.6 0.18 11.9 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 PIK53844.1 - 0.0013 18.7 2.0 0.0023 17.9 0.0 2.3 2 1 1 3 3 3 1 Galactose oxidase, central domain Ribosomal_L17 PF01196.19 PIK53845.1 - 2.1e-18 67.0 0.0 3e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 INSIG PF07281.12 PIK53846.1 - 4.4e-47 160.5 10.6 5.4e-46 156.9 10.6 2.3 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) DUF202 PF02656.15 PIK53846.1 - 1.5 9.3 8.7 0.5 10.8 0.9 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF202) YiaAB PF05360.14 PIK53846.1 - 6.6 7.1 11.9 41 4.5 3.3 3.9 3 1 0 3 3 3 0 yiaA/B two helix domain KOG2701 PF09762.9 PIK53848.1 - 2.3e-48 164.8 0.9 2.3e-48 164.8 0.9 5.0 2 2 1 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) FUSC PF04632.12 PIK53848.1 - 0.35 9.3 12.5 0.27 9.7 11.0 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family BAG PF02179.16 PIK53848.1 - 2.2 8.8 14.9 4.2 7.9 3.6 4.0 2 1 1 3 3 3 0 BAG domain Fib_alpha PF08702.10 PIK53848.1 - 3.7 7.7 32.2 0.15 12.2 7.3 4.2 3 2 1 4 4 4 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 PIK53848.1 - 4.6 7.6 14.1 2.3 8.5 3.9 3.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TPP_enzyme_N PF02776.18 PIK53849.1 - 7.1e-38 129.9 0.0 3.4e-36 124.4 0.0 2.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 PIK53849.1 - 6.5e-31 106.9 0.0 1.3e-30 105.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 PIK53849.1 - 2.8e-26 92.1 0.0 5.5e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 PIK53849.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit DSPc PF00782.20 PIK53850.1 - 2.6e-20 72.6 0.0 3.2e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 PIK53850.1 - 0.01 16.1 0.0 0.016 15.5 0.0 1.3 1 1 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase PF00102.27 PIK53850.1 - 0.03 13.9 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Arm-DNA-bind_2 PF12167.8 PIK53850.1 - 0.16 11.9 0.5 0.43 10.5 0.1 1.8 2 0 0 2 2 2 0 Arm DNA-binding domain Phage_GPL PF05926.11 PIK53851.1 - 0.0026 17.8 1.0 0.0058 16.6 1.0 1.5 1 0 0 1 1 1 1 Phage head completion protein (GPL) DUF4752 PF15944.5 PIK53851.1 - 0.26 11.3 6.7 0.049 13.7 1.1 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF4752) Baculo_PEP_C PF04513.12 PIK53852.1 - 0.34 10.9 3.2 0.3 11.1 0.2 2.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-HC5HC2H PF13771.6 PIK53853.1 - 1.3e-15 57.4 8.4 1.3e-15 57.4 8.4 1.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 PIK53853.1 - 1.3e-14 54.3 7.5 1.9e-14 53.7 7.5 1.2 1 0 0 1 1 1 1 PHD-zinc-finger like domain Peptidase_C74 PF12387.8 PIK53853.1 - 0.079 12.4 0.3 0.11 11.9 0.3 1.1 1 0 0 1 1 1 0 Pestivirus NS2 peptidase PHD PF00628.29 PIK53853.1 - 0.36 10.8 6.9 0.83 9.6 6.9 1.7 1 0 0 1 1 1 0 PHD-finger Myb_DNA-binding PF00249.31 PIK53855.1 - 2.5e-06 27.6 0.2 3.4e-06 27.1 0.2 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK53855.1 - 0.0012 19.0 0.4 0.0014 18.8 0.4 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain DnaJ PF00226.31 PIK53856.1 - 1.7e-21 76.1 0.4 4e-21 74.9 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 PIK53856.1 - 9.8e-05 22.5 0.1 0.00037 20.6 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK53856.1 - 0.017 15.4 0.0 0.049 13.9 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 PIK53856.1 - 0.42 10.7 4.4 16 5.7 0.1 3.8 3 2 1 4 4 4 0 Myb/SANT-like DNA-binding domain WD40 PF00400.32 PIK53857.1 - 1.3e-13 51.2 6.1 0.00081 20.2 0.1 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF_4EBP PF05456.11 PIK53857.1 - 0.053 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) C1_1 PF00130.22 PIK53857.1 - 0.11 12.4 2.9 0.31 11.0 2.9 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ANAPC4_WD40 PF12894.7 PIK53858.1 - 7e-08 32.7 0.0 2.5 8.5 0.0 5.6 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK53858.1 - 0.0008 19.3 0.0 8.3 6.2 0.0 3.8 3 1 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 PIK53858.1 - 0.0014 19.4 0.2 0.0014 19.4 0.2 4.7 5 1 1 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK53859.1 - 0.0085 16.4 0.1 1.5 9.2 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain zinc_ribbon_16 PF17034.5 PIK53861.1 - 4.7e-21 75.3 10.9 9.1e-21 74.4 10.9 1.5 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 PIK53861.1 - 0.00019 21.0 13.0 0.00019 21.0 13.0 3.0 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type Rhodanese_C PF12368.8 PIK53861.1 - 9.4 6.7 11.8 5.6 7.4 0.0 3.6 3 1 0 3 3 3 0 Rhodanase C-terminal Rep_fac-A_3 PF08661.11 PIK53862.1 - 2.8e-20 72.6 0.0 3.6e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 TRAM_LAG1_CLN8 PF03798.16 PIK53863.1 - 2.2e-16 60.2 13.9 2.6e-16 60.0 13.9 1.0 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 PIK53864.1 - 3.5e-05 23.6 1.9 6e-05 22.8 1.9 1.4 1 0 0 1 1 1 1 Homeodomain TRAM_LAG1_CLN8 PF03798.16 PIK53864.1 - 0.0089 15.8 4.5 0.01 15.5 4.5 1.1 1 0 0 1 1 1 1 TLC domain Ribosomal_L27e PF01777.18 PIK53865.1 - 7.9e-25 87.0 10.2 4.6e-23 81.4 10.2 2.1 1 1 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 PIK53865.1 - 7.9e-07 28.8 0.1 2.4e-06 27.3 0.1 1.8 1 0 0 1 1 1 1 KOW motif S1FA PF04689.13 PIK53865.1 - 9.3 6.5 8.4 2 8.6 1.3 2.4 2 0 0 2 2 2 0 DNA binding protein S1FA Tubulin PF00091.25 PIK53866.1 - 2.4e-59 200.9 0.0 3.3e-59 200.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK53866.1 - 1.9e-34 118.6 0.0 6.8e-34 116.8 0.0 2.0 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 PIK53866.1 - 0.0075 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin like ABC_tran PF00005.27 PIK53867.1 - 1.7e-22 80.4 0.0 6.7e-22 78.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_tran_Xtn PF12848.7 PIK53867.1 - 3e-18 65.6 5.7 7.8e-18 64.3 1.2 2.8 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 PIK53867.1 - 2.5e-12 47.2 0.6 6e-06 26.3 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK53867.1 - 2.2e-05 24.0 0.0 0.18 11.2 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 PIK53867.1 - 0.0017 18.9 1.0 0.0079 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 PIK53867.1 - 0.002 17.8 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 PIK53867.1 - 0.0021 17.9 0.3 0.013 15.2 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 PIK53867.1 - 0.0059 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 PIK53867.1 - 0.013 15.6 0.0 0.028 14.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 PIK53867.1 - 0.015 15.8 0.1 0.11 13.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain DUF3584 PF12128.8 PIK53867.1 - 0.025 12.1 0.8 0.087 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_33 PF13671.6 PIK53867.1 - 0.029 14.5 0.1 0.066 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 PIK53867.1 - 0.038 14.1 1.5 0.16 12.0 0.0 2.3 3 0 0 3 3 3 0 Helicase HerA, central domain MukB PF04310.12 PIK53867.1 - 0.056 13.2 0.3 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 MukB N-terminal Dynamin_N PF00350.23 PIK53867.1 - 0.091 12.8 0.3 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 PIK53867.1 - 0.093 12.4 0.0 0.25 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 PIK53867.1 - 0.1 12.5 0.5 0.46 10.4 0.1 2.0 2 1 1 3 3 3 0 NTPase AAA PF00004.29 PIK53867.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 PIK53867.1 - 0.13 12.0 0.0 0.49 10.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain Peptidase_S64 PF08192.11 PIK53868.1 - 0.24 9.8 3.6 0.27 9.7 3.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 7tm_1 PF00001.21 PIK53869.1 - 2.1e-35 122.3 2.2 2.9e-35 121.9 2.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK53869.1 - 7.2e-17 61.9 5.3 9e-17 61.6 5.3 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK53869.1 - 4.2e-12 46.0 3.8 5.5e-12 45.6 3.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK53869.1 - 3.6e-09 36.4 0.3 3.6e-09 36.4 0.3 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.8 PIK53869.1 - 6e-08 32.7 7.8 8.1e-08 32.3 7.8 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srt PF10321.9 PIK53869.1 - 8.4e-06 25.0 6.3 1.1e-05 24.5 6.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt CbtA PF09490.10 PIK53869.1 - 0.019 14.7 2.5 0.21 11.3 0.4 2.2 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) COX14 PF14880.6 PIK53869.1 - 0.1 12.5 0.5 9.9 6.1 0.1 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Frag1 PF10277.9 PIK53869.1 - 0.36 10.3 10.4 0.12 11.8 2.9 2.8 3 0 0 3 3 3 0 Frag1/DRAM/Sfk1 family 7tm_1 PF00001.21 PIK53870.1 - 2.3e-39 135.3 5.3 3e-39 134.9 5.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK53870.1 - 2.4e-14 53.6 4.2 2.4e-14 53.6 4.2 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK53870.1 - 2.9e-08 33.4 3.8 1.6e-07 31.0 0.8 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK53870.1 - 4.6e-07 29.5 8.3 1.4e-05 24.6 2.9 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF621 PF04789.15 PIK53870.1 - 0.031 13.5 4.4 0.079 12.1 4.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF621) Git3 PF11710.8 PIK53870.1 - 0.04 13.7 7.6 0.088 12.6 7.6 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 DUF2721 PF11026.8 PIK53870.1 - 0.14 12.0 0.0 0.14 12.0 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) DUF4064 PF13273.6 PIK53870.1 - 0.49 10.7 8.3 1.7 8.9 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Integrin_alpha2 PF08441.12 PIK53871.1 - 2.1e-56 191.8 0.0 2e-27 96.2 0.0 2.1 2 0 0 2 2 2 2 Integrin alpha FG-GAP PF01839.23 PIK53871.1 - 2.2e-22 78.8 13.9 3.2e-09 36.7 0.0 4.9 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.6 PIK53871.1 - 1.2e-10 41.8 9.2 2.2e-07 31.4 0.7 4.5 2 1 4 6 6 6 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 PIK53871.1 - 0.31 11.1 3.1 0.71 10.0 3.1 1.6 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region Granulin PF00396.18 PIK53873.1 - 6.7e-106 346.4 266.6 2e-17 63.2 21.6 15.1 12 3 4 16 16 16 11 Granulin DUF892 PF05974.12 PIK53873.1 - 0.77 9.8 6.1 60 3.6 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF892) BRD4_CDT PF17105.5 PIK53873.1 - 4.6 6.9 5.3 1.8e+02 1.9 0.0 4.3 5 0 0 5 5 5 0 C-terminal domain of bromodomain protein 4 AIG1 PF04548.16 PIK53874.1 - 1.2e-25 90.2 1.8 1.5e-25 89.8 1.8 1.1 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 PIK53874.1 - 0.012 15.7 0.3 0.026 14.6 0.0 1.8 2 0 0 2 2 2 0 Dynamin family MMR_HSR1 PF01926.23 PIK53874.1 - 0.032 14.3 0.1 0.075 13.1 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase COesterase PF00135.28 PIK53875.1 - 1.9e-100 337.2 0.0 2.5e-100 336.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK53875.1 - 2.6e-09 37.3 0.5 7.8e-09 35.7 0.5 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 PIK53876.1 - 2.4e-119 399.5 0.0 2.9e-119 399.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK53876.1 - 5.2e-08 33.0 0.0 2.2e-07 31.0 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ank_2 PF12796.7 PIK53877.1 - 1.4e-16 60.8 1.2 2.4e-12 47.3 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK53877.1 - 6.4e-13 48.7 0.2 1.7e-05 25.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK53877.1 - 1.4e-10 41.4 0.0 3.6e-06 27.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK53877.1 - 6.1e-10 39.1 0.0 0.0001 22.6 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK53877.1 - 1.4e-07 31.2 0.0 0.00025 21.3 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat DAGK_acc PF00609.19 PIK53878.1 - 1.3e-37 129.5 0.0 3e-36 125.2 0.0 2.7 2 1 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 PIK53878.1 - 2.3e-25 88.7 0.0 4.4e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 PIK53878.1 - 1.2e-14 54.0 24.4 1.9e-11 43.6 12.0 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 PIK53878.1 - 1.3 8.7 8.2 3.5 7.3 1.9 2.7 2 0 0 2 2 2 0 PHD-finger Glyco_transf_29 PF00777.18 PIK53879.1 - 3.7e-60 203.6 0.7 5.2e-60 203.1 0.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Jiv90 PF14901.6 PIK53879.1 - 0.039 14.1 1.5 0.1 12.8 1.0 1.9 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone DUF2251 PF10008.9 PIK53879.1 - 0.069 13.3 0.2 0.2 11.8 0.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) Ribosomal_L3 PF00297.22 PIK53880.1 - 1.2e-29 103.4 3.5 7.8e-27 94.2 2.7 2.8 2 1 0 2 2 2 1 Ribosomal protein L3 CAP_GLY PF01302.25 PIK53881.1 - 6.7e-12 45.2 0.1 1.9e-11 43.8 0.1 1.8 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_1 PF00036.32 PIK53881.1 - 2.8e-07 29.6 6.5 0.0025 17.2 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK53881.1 - 1.3e-06 27.8 2.4 0.011 15.6 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK53881.1 - 1.7e-06 28.4 8.4 0.0016 18.9 0.3 4.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK53881.1 - 3.4e-05 23.6 3.8 0.0057 16.5 0.3 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK53881.1 - 7.8e-05 22.0 6.0 0.018 14.5 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 PIK53881.1 - 0.016 15.1 1.1 4.8 7.2 0.1 3.2 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF948 PF06103.11 PIK53881.1 - 3.5 8.0 14.5 0.86 9.9 1.3 3.6 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 PIK53881.1 - 4.9 7.7 11.5 12 6.4 0.0 4.2 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Branch PF02485.21 PIK53884.1 - 4.7e-48 163.8 0.0 6.6e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Peptidase_S8 PF00082.22 PIK53886.1 - 4.4e-38 131.2 0.1 7e-38 130.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family DOR PF14839.6 PIK53888.1 - 0.0059 16.6 8.6 0.018 15.0 0.1 2.5 1 1 2 3 3 3 2 DOR family RsgA_N PF16745.5 PIK53888.1 - 0.1 12.3 0.4 0.22 11.3 0.4 1.6 1 1 0 1 1 1 0 RsgA N-terminal domain BtpA PF03437.15 PIK53889.1 - 1.7e-61 207.9 0.3 2.1e-61 207.6 0.3 1.0 1 0 0 1 1 1 1 BtpA family His_biosynth PF00977.21 PIK53889.1 - 0.022 14.2 0.1 0.095 12.1 0.0 2.0 2 1 0 2 2 2 0 Histidine biosynthesis protein Cyclin_N PF00134.23 PIK53890.1 - 3.9e-41 139.8 0.1 8.4e-41 138.7 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2065 PF09838.9 PIK53890.1 - 0.19 11.8 0.2 34 4.6 0.0 3.0 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2065) Prefoldin PF02996.17 PIK53891.1 - 3.9e-19 68.7 0.1 9.5e-19 67.5 0.1 1.6 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 PIK53891.1 - 1.6e-06 28.1 0.1 1.6e-06 28.1 0.1 2.3 2 1 1 3 3 3 1 Prefoldin subunit Sas6_CC PF18594.1 PIK53891.1 - 0.42 10.4 7.1 0.14 12.0 0.4 2.9 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Complex1_LYR PF05347.15 PIK53892.1 - 5e-07 29.7 1.7 9.9e-07 28.7 1.7 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) WD40 PF00400.32 PIK53893.1 - 1.1e-23 83.0 18.4 6.3e-06 26.8 0.5 7.0 7 0 0 7 7 6 4 WD domain, G-beta repeat zf-RING_UBOX PF13445.6 PIK53893.1 - 3.2e-07 30.3 8.6 1.5e-06 28.2 8.6 2.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK53893.1 - 5.2e-07 29.4 6.4 2.5e-06 27.2 6.4 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK53893.1 - 4.6e-06 26.7 7.8 4.6e-06 26.7 7.8 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK53893.1 - 2.9e-05 23.8 6.6 0.00014 21.7 6.6 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK53893.1 - 0.00036 20.4 6.0 0.00036 20.4 6.0 3.4 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 PIK53893.1 - 0.00044 20.0 4.2 0.00044 20.0 4.2 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein ANAPC4_WD40 PF12894.7 PIK53893.1 - 0.00048 20.4 0.1 0.0089 16.3 0.0 3.1 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain zf-Nse PF11789.8 PIK53893.1 - 0.00086 19.1 2.7 0.00086 19.1 2.7 2.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 PIK53893.1 - 0.012 15.9 6.8 0.012 15.9 6.8 3.3 2 1 0 2 2 1 0 Ring finger domain PI3K_P85_iSH2 PF16454.5 PIK53893.1 - 0.014 15.0 1.7 0.024 14.2 1.7 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf-TRAF PF02176.18 PIK53893.1 - 0.063 14.0 9.1 0.16 12.7 7.6 2.6 1 1 0 1 1 1 0 TRAF-type zinc finger Tropomyosin_1 PF12718.7 PIK53893.1 - 0.079 13.1 2.3 0.14 12.3 2.3 1.4 1 0 0 1 1 1 0 Tropomyosin like HrpB7 PF09486.10 PIK53893.1 - 0.11 12.9 0.6 0.19 12.1 0.6 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Prefoldin PF02996.17 PIK53893.1 - 0.17 11.8 1.1 0.32 10.9 1.1 1.4 1 0 0 1 1 1 0 Prefoldin subunit Trimer_CC PF08954.11 PIK53893.1 - 0.31 10.6 2.0 0.7 9.5 2.0 1.5 1 0 0 1 1 1 0 Trimerisation motif ACCA PF03255.14 PIK53893.1 - 0.56 10.1 1.5 1 9.2 1.5 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit tRNA-synt_2c PF01411.19 PIK53894.1 - 1.5e-23 83.1 0.1 2.7e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 PIK53894.1 - 2.9e-17 62.5 1.5 3.1e-17 62.4 0.1 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 PIK53894.1 - 1.7e-07 31.8 5.3 2.2e-07 31.4 1.8 2.4 2 0 0 2 2 2 1 DHHA1 domain SH3_7 PF12914.7 PIK53894.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 SH3 domain of SH3b2 type Nrap_D5 PF17406.2 PIK53894.1 - 0.22 11.3 0.9 0.59 9.9 0.8 1.8 1 1 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 UTP15_C PF09384.10 PIK53894.1 - 0.34 10.6 2.9 16 5.1 0.1 2.8 1 1 1 3 3 3 0 UTP15 C terminal DUF1664 PF07889.12 PIK53894.1 - 0.51 10.4 4.0 1.3 9.1 4.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) BshC PF10079.9 PIK53894.1 - 0.75 8.5 4.8 0.72 8.5 3.7 1.4 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC DUF1690 PF07956.11 PIK53894.1 - 2.5 8.5 8.0 13 6.2 5.7 2.4 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) tRNA-synt_2c PF01411.19 PIK53895.1 - 1.5e-63 215.2 0.0 1.7e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA-synt_2c PF01411.19 PIK53896.1 - 3.7e-86 289.8 0.0 4.3e-86 289.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (A) Tail_spike_N PF18668.1 PIK53897.1 - 0.017 15.0 0.0 0.053 13.4 0.0 1.8 1 0 0 1 1 1 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain PBP5_C PF07943.13 PIK53897.1 - 0.79 10.0 3.6 5.7 7.2 0.2 3.2 1 1 1 3 3 3 0 Penicillin-binding protein 5, C-terminal domain PIF1 PF05970.14 PIK53898.1 - 4.4e-19 68.9 0.9 1.2e-18 67.5 0.9 1.6 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 PIK53898.1 - 2e-18 66.8 0.0 3.5e-18 66.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK53898.1 - 1.6e-09 38.2 0.1 4e-09 37.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 PIK53898.1 - 0.0031 17.3 0.0 0.12 12.1 0.0 2.3 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 PIK53898.1 - 0.011 16.1 0.0 0.047 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 PIK53898.1 - 0.026 14.8 1.1 0.13 12.5 0.2 2.3 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK53898.1 - 0.062 13.7 0.1 0.1 13.0 0.1 1.6 1 1 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 PIK53898.1 - 0.065 13.2 0.2 0.28 11.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 PIK53898.1 - 0.068 12.9 0.1 0.16 11.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 PIK53898.1 - 0.076 12.9 0.2 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA PF00004.29 PIK53898.1 - 0.079 13.4 2.4 0.23 11.9 0.9 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK53898.1 - 0.084 13.4 0.0 0.34 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 PIK53898.1 - 0.089 12.5 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RabGAP-TBC PF00566.18 PIK53899.1 - 2e-07 30.9 7.9 2e-07 30.9 7.9 2.3 2 1 0 2 2 2 1 Rab-GTPase-TBC domain WD40_like PF17005.5 PIK53899.1 - 6.5e-05 22.4 0.0 0.00016 21.1 0.0 1.6 1 0 0 1 1 1 1 WD40-like domain WD40 PF00400.32 PIK53899.1 - 0.00022 22.0 5.5 1 10.4 0.4 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Phage_HK97_TLTM PF06120.11 PIK53899.1 - 0.73 9.0 15.5 0.26 10.4 2.1 2.5 1 1 0 2 2 2 0 Tail length tape measure protein LRR_8 PF13855.6 PIK53900.1 - 2.4e-67 222.6 78.2 5.3e-15 54.9 1.1 8.1 3 2 5 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 PIK53900.1 - 1.7e-35 120.4 60.4 1e-05 25.8 0.6 9.3 6 1 2 9 9 9 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53900.1 - 7.7e-26 90.6 14.5 1.3e-07 31.7 0.1 4.1 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK53900.1 - 8.5e-18 62.2 42.1 0.07 13.7 0.2 14.7 15 1 0 15 15 15 5 Leucine Rich Repeat LRR_9 PF14580.6 PIK53900.1 - 3.5e-13 49.4 29.7 0.00025 20.6 2.6 5.0 1 1 4 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 PIK53900.1 - 0.48 10.6 59.7 2.1 8.6 0.1 12.4 15 0 0 15 15 15 0 Leucine Rich repeat FNIP PF05725.12 PIK53900.1 - 0.94 9.7 12.5 2.1 8.6 0.4 6.3 6 4 1 7 7 7 0 FNIP Repeat LRR_8 PF13855.6 PIK53901.1 - 1.2e-32 111.5 21.7 2.9e-15 55.8 2.4 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK53901.1 - 6.6e-09 35.9 8.4 1.4e-05 25.3 1.4 3.9 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53901.1 - 1.2e-07 31.8 0.0 2.5e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK53901.1 - 1.5e-06 27.8 3.2 0.0015 18.1 1.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK53901.1 - 1.5e-05 24.9 11.6 0.11 13.1 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich Repeat LRRNT PF01462.18 PIK53901.1 - 0.0041 16.7 0.3 0.0068 16.0 0.3 1.4 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 PIK53901.1 - 0.063 13.4 9.9 6.7 7.0 0.1 5.2 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 PIK53902.1 - 2e-63 210.0 56.5 7.2e-13 48.1 4.9 10.2 4 4 6 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 PIK53902.1 - 8e-27 92.9 62.9 7.6e-05 23.0 2.2 11.3 9 3 3 12 12 12 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53902.1 - 8.1e-20 71.1 18.2 1.5e-06 28.2 0.8 4.7 3 2 1 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK53902.1 - 5.1e-08 32.4 44.9 0.088 13.4 0.2 15.0 17 1 0 17 17 17 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK53902.1 - 1.5e-06 27.8 29.4 0.00041 19.9 2.8 6.0 1 1 5 6 6 6 5 Leucine-rich repeat LRR_6 PF13516.6 PIK53902.1 - 0.25 11.5 0.0 0.25 11.5 0.0 13.3 17 0 0 17 17 17 0 Leucine Rich repeat Herpes_gE PF02480.16 PIK53903.1 - 0.0039 16.0 0.0 0.0052 15.6 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E LRR_8 PF13855.6 PIK53903.1 - 0.0078 16.0 1.3 0.013 15.2 1.3 1.4 1 0 0 1 1 1 1 Leucine rich repeat EphA2_TM PF14575.6 PIK53903.1 - 0.014 16.2 0.0 0.021 15.7 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LRR_8 PF13855.6 PIK53904.1 - 4e-52 173.8 32.5 3.3e-11 42.8 0.1 7.1 4 3 4 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 PIK53904.1 - 4.4e-23 81.0 32.1 0.00042 20.6 3.7 8.9 6 1 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53904.1 - 3.5e-15 56.1 12.5 0.00014 21.9 0.8 3.8 1 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK53904.1 - 4.6e-13 47.8 21.3 1.6 9.6 0.0 11.4 13 2 0 13 13 13 5 Leucine Rich Repeat LRR_6 PF13516.6 PIK53904.1 - 2.4e-07 30.3 30.4 0.005 16.8 0.1 9.9 12 0 0 12 12 12 3 Leucine Rich repeat LRR_9 PF14580.6 PIK53904.1 - 9.3e-07 28.5 10.4 0.23 10.9 0.1 4.9 1 1 4 5 5 5 4 Leucine-rich repeat LRR_8 PF13855.6 PIK53905.1 - 1.2e-62 207.5 50.8 5e-15 55.0 1.1 7.1 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK53905.1 - 1.2e-28 98.7 41.7 8.3e-06 26.1 0.4 7.9 5 1 3 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53905.1 - 5e-25 87.9 2.1 2.2e-09 37.4 0.0 3.5 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK53905.1 - 5.2e-17 59.8 32.5 0.26 12.0 0.0 12.9 14 0 0 14 14 14 5 Leucine Rich Repeat LRR_9 PF14580.6 PIK53905.1 - 2.4e-14 53.2 18.0 0.00055 19.5 0.5 4.2 1 1 2 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 PIK53905.1 - 6.1e-06 25.9 40.3 0.86 9.8 0.2 11.8 13 0 0 13 13 13 4 Leucine Rich repeat LRRNT PF01462.18 PIK53905.1 - 0.078 12.7 0.3 0.17 11.6 0.3 1.6 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain FNIP PF05725.12 PIK53905.1 - 2.3 8.5 11.8 0.74 10.0 0.2 5.2 5 2 1 6 6 6 0 FNIP Repeat Pkinase PF00069.25 PIK53906.1 - 2e-11 43.8 0.0 2.3e-11 43.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53906.1 - 9.4e-07 28.4 0.0 1.1e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK53906.1 - 0.00028 20.3 0.0 0.00048 19.6 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_8 PF13855.6 PIK53907.1 - 6e-09 35.5 1.2 1.1e-08 34.7 1.2 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.6 PIK53907.1 - 3.2e-05 23.6 2.2 0.0036 17.2 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.7 PIK53907.1 - 0.0007 19.9 1.6 0.0015 18.9 1.3 1.8 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) Herpes_gE PF02480.16 PIK53907.1 - 0.0034 16.2 0.0 0.0047 15.7 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E LRR_1 PF00560.33 PIK53907.1 - 0.022 15.3 1.7 1.5 9.6 0.0 3.2 1 1 1 2 2 2 0 Leucine Rich Repeat EphA2_TM PF14575.6 PIK53907.1 - 0.029 15.3 0.0 0.043 14.7 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LRR_8 PF13855.6 PIK53908.1 - 2.5e-26 91.2 10.6 4.9e-13 48.6 0.6 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK53908.1 - 9.3e-11 41.8 5.3 0.00014 22.1 1.2 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK53908.1 - 3.8e-09 35.8 2.3 0.051 14.1 0.0 4.2 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_5 PF13306.6 PIK53908.1 - 3e-07 30.5 0.0 3.5e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK53908.1 - 0.00012 21.9 3.0 0.29 11.3 0.2 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_9 PF14580.6 PIK53908.1 - 0.00015 21.3 1.1 0.0014 18.1 0.1 1.9 1 1 1 2 2 2 1 Leucine-rich repeat FNIP PF05725.12 PIK53908.1 - 0.12 12.6 2.9 0.42 10.8 0.6 2.7 2 1 1 3 3 3 0 FNIP Repeat 7tm_1 PF00001.21 PIK53909.1 - 5.9e-30 104.5 7.7 6.7e-30 104.3 7.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK53909.1 - 2.3e-09 37.3 10.8 3.7e-09 36.6 10.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK53909.1 - 1.4e-05 24.9 4.5 2.4e-05 24.2 4.5 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 PIK53909.1 - 0.019 14.3 15.3 0.017 14.5 13.1 1.9 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK53909.1 - 0.038 13.4 10.7 0.073 12.4 10.7 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx HECT PF00632.25 PIK53910.1 - 1.4e-09 37.9 0.1 1.5e-07 31.2 0.1 2.1 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) Rad60-SLD PF11976.8 PIK53910.1 - 0.028 14.3 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like rve PF00665.26 PIK53911.1 - 6e-07 29.7 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_7 PF02796.15 PIK53911.1 - 0.0049 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 PIK53911.1 - 0.017 14.9 0.0 0.072 12.9 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 PIK53911.1 - 0.04 13.7 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_11 PF08279.12 PIK53911.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 HTH domain Peptidase_A17 PF05380.13 PIK53913.1 - 3e-56 189.9 0.0 5.1e-56 189.1 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK53913.1 - 0.00074 19.5 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) RVT_1 PF00078.27 PIK53913.1 - 0.031 13.8 0.0 0.23 11.0 0.0 2.1 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TIR_2 PF13676.6 PIK53916.1 - 1.5e-13 51.4 0.5 1.4e-06 28.9 0.0 2.7 3 0 0 3 3 3 2 TIR domain TIR PF01582.20 PIK53916.1 - 0.023 14.5 0.0 0.097 12.5 0.0 2.0 2 0 0 2 2 2 0 TIR domain BEX PF04538.12 PIK53916.1 - 0.11 13.1 0.8 0.21 12.2 0.8 1.4 1 0 0 1 1 1 0 Brain expressed X-linked like family Mcp5_PH PF12814.7 PIK53916.1 - 0.15 12.2 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology WD40 PF00400.32 PIK53917.1 - 2.3e-20 72.5 12.6 2.5e-06 28.1 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 PIK53917.1 - 6.4e-15 55.2 0.2 7.5e-12 45.3 0.0 3.3 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.11 PIK53917.1 - 7e-06 26.1 0.5 2.6e-05 24.2 0.2 2.1 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 PIK53917.1 - 2.8e-05 24.3 0.4 0.087 13.1 0.3 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain HRM PF02793.22 PIK53917.1 - 0.22 11.8 0.8 1.2 9.4 0.3 2.3 2 0 0 2 2 2 0 Hormone receptor domain T4bSS_IcmS PF12608.8 PIK53917.1 - 0.43 10.9 9.0 2 8.8 2.6 2.5 2 0 0 2 2 2 0 Type IVb secretion, IcmS, effector-recruitment SPT2 PF08243.11 PIK53917.1 - 0.65 10.6 8.3 0.54 10.8 0.5 2.5 2 0 0 2 2 2 0 SPT2 chromatin protein CENP-B_dimeris PF09026.10 PIK53917.1 - 7.2 7.1 21.5 0.47 10.9 5.3 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PKD_channel PF08016.12 PIK53918.1 - 1e-87 294.6 15.7 1.6e-87 293.9 15.7 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 PIK53918.1 - 2.1e-09 37.0 21.9 2.1e-09 37.0 21.9 1.7 2 0 0 2 2 2 1 Ion transport protein DUF3566 PF12089.8 PIK53918.1 - 0.98 9.8 7.6 4 7.8 2.4 3.0 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) Claudin_3 PF06653.11 PIK53918.1 - 5.2 7.0 15.4 0.02 14.8 3.4 2.8 2 1 1 3 3 3 0 Tight junction protein, Claudin-like REJ PF02010.15 PIK53919.1 - 2.2e-98 330.0 0.0 3.8e-98 329.2 0.0 1.4 1 0 0 1 1 1 1 REJ domain PLAT PF01477.23 PIK53919.1 - 5.7e-16 59.1 3.2 6.2e-16 59.0 0.0 2.8 4 0 0 4 4 4 1 PLAT/LH2 domain GPS PF01825.21 PIK53919.1 - 6.3e-08 33.0 0.9 2e-07 31.4 0.9 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD PF00801.20 PIK53919.1 - 1.4e-05 24.8 1.4 0.016 15.1 0.2 3.7 3 1 0 3 3 3 2 PKD domain DUF2508 PF10704.9 PIK53919.1 - 0.75 10.0 7.6 1.9 8.7 7.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) DUF4363 PF14276.6 PIK53921.1 - 0.09 12.9 0.2 8.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) YfdX PF10938.8 PIK53921.1 - 0.22 11.4 0.0 0.38 10.7 0.0 1.3 1 0 0 1 1 1 0 YfdX protein DUF1263 PF06882.12 PIK53922.1 - 0.097 12.7 1.3 3.5 7.8 0.1 3.6 2 1 1 4 4 4 0 Protein of unknown function (DUF1263) Lectin_C PF00059.21 PIK53923.1 - 1.5e-12 48.2 2.3 3.4e-12 47.1 2.3 1.6 1 1 0 1 1 1 1 Lectin C-type domain OATP PF03137.20 PIK53924.1 - 2.5e-40 138.3 2.8 4.5e-32 111.1 0.0 2.1 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK53924.1 - 0.00093 19.3 10.3 0.002 18.2 10.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK53924.1 - 0.011 15.7 5.2 0.025 14.6 5.2 1.6 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Sugarporin_N PF11471.8 PIK53924.1 - 0.21 11.6 0.2 0.56 10.2 0.2 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension TIL PF01826.17 PIK53924.1 - 8 6.8 10.3 8.4 6.7 1.6 2.4 1 1 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain Pkinase PF00069.25 PIK53925.1 - 4.6e-63 213.0 0.0 5.8e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK53925.1 - 5.5e-36 124.2 0.0 7.1e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK53925.1 - 1.2e-10 41.2 0.0 3.1e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK53925.1 - 0.00015 21.2 0.1 0.00024 20.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_11 PF18103.1 PIK53925.1 - 0.066 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Retroviral integrase C-terminal SH3 domain Sel1 PF08238.12 PIK53926.1 - 3.2e-08 34.0 8.5 0.25 12.1 0.0 4.7 5 0 0 5 5 5 4 Sel1 repeat SNAP PF14938.6 PIK53926.1 - 0.11 11.8 3.6 0.59 9.5 0.6 2.2 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP Alpha_kinase PF02816.18 PIK53927.1 - 1.9e-59 200.9 2.3 3.6e-59 200.0 0.5 2.0 2 0 0 2 2 2 1 Alpha-kinase family Rad51 PF08423.11 PIK53928.1 - 2.9e-95 318.4 0.0 4.5e-95 317.8 0.0 1.2 1 0 0 1 1 1 1 Rad51 HHH_5 PF14520.6 PIK53928.1 - 7.6e-07 29.6 1.4 2.2e-06 28.2 0.8 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_25 PF13481.6 PIK53928.1 - 0.00013 21.7 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 PIK53928.1 - 0.012 14.9 0.1 0.032 13.6 0.0 1.8 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Sad1_UNC PF07738.13 PIK53929.1 - 3.9e-39 133.7 0.0 9.2e-39 132.5 0.0 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Urocanase PF01175.18 PIK53929.1 - 0.055 13.1 0.4 3.1 7.4 0.0 2.9 2 0 0 2 2 2 0 Urocanase Rossmann-like domain APC_N_CC PF16689.5 PIK53929.1 - 0.073 13.1 7.1 2.1 8.5 0.6 4.7 3 1 1 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain Methyltransf_16 PF10294.9 PIK53931.1 - 6.7e-07 29.2 0.0 8.4e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Myosin_tail_1 PF01576.19 PIK53933.1 - 1.3e-117 394.2 83.9 1.4e-117 394.0 83.9 1.0 1 0 0 1 1 1 1 Myosin tail ERM PF00769.19 PIK53933.1 - 0.0021 17.9 83.9 0.3 10.9 9.8 3.3 2 1 1 3 3 3 3 Ezrin/radixin/moesin family GAS PF13851.6 PIK53933.1 - 0.016 14.5 67.3 0.18 11.2 30.4 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Sin3_corepress PF08295.12 PIK53933.1 - 0.62 10.2 28.8 1.5 8.9 1.7 4.3 4 1 0 4 4 4 0 Sin3 family co-repressor ADIP PF11559.8 PIK53933.1 - 0.69 10.0 70.8 4.1 7.5 18.1 5.0 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Hormone_1 PF00103.20 PIK53933.1 - 0.81 9.4 22.8 0.063 13.0 1.3 4.2 1 1 2 4 4 4 0 Somatotropin hormone family MAD PF05557.13 PIK53933.1 - 2.4 6.4 74.8 0.017 13.5 46.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein FlxA PF14282.6 PIK53933.1 - 2.5 8.1 66.5 0.043 13.8 11.4 4.8 1 1 4 5 5 5 0 FlxA-like protein DUF4407 PF14362.6 PIK53933.1 - 4.7 6.5 61.1 0.082 12.3 22.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) BRI3BP PF14965.6 PIK53933.1 - 6.7 6.2 13.1 1.3 8.5 0.3 3.8 3 1 1 4 4 4 0 Negative regulator of p53/TP53 Baculo_PEP_C PF04513.12 PIK53933.1 - 8.2 6.5 25.9 0.33 11.0 3.3 4.2 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Myosin_tail_1 PF01576.19 PIK53934.1 - 1.2e-190 636.0 150.0 1.3e-190 635.9 150.0 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.21 PIK53934.1 - 1.2e-05 25.1 122.0 0.0001 22.0 60.8 2.8 1 1 1 2 2 2 2 Intermediate filament protein DUF4201 PF13870.6 PIK53934.1 - 0.00037 20.3 13.9 0.00037 20.3 13.9 7.3 1 1 4 6 6 6 2 Domain of unknown function (DUF4201) DUF4200 PF13863.6 PIK53934.1 - 0.029 14.8 7.0 0.029 14.8 7.0 7.8 2 1 6 8 8 8 0 Domain of unknown function (DUF4200) EzrA PF06160.12 PIK53934.1 - 0.086 11.0 100.5 0.11 10.6 74.9 4.5 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA Laminin_II PF06009.12 PIK53934.1 - 0.4 10.7 86.7 0.035 14.1 14.3 6.7 1 1 4 6 6 6 0 Laminin Domain II DUF1664 PF07889.12 PIK53934.1 - 0.49 10.4 72.4 0.85 9.7 1.9 7.3 2 2 6 8 8 8 0 Protein of unknown function (DUF1664) Myosin_head PF00063.21 PIK53935.1 - 3.2e-186 620.5 0.1 7e-186 619.4 0.1 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 PIK53935.1 - 2.7e-52 177.8 38.6 3.3e-52 177.6 38.6 1.1 1 0 0 1 1 1 1 Myosin tail IQ PF00612.27 PIK53935.1 - 0.0001 21.8 4.5 0.0006 19.4 0.3 2.9 2 0 0 2 2 2 1 IQ calmodulin-binding motif Erf4 PF10256.9 PIK53935.1 - 0.047 13.8 1.6 0.18 11.9 0.2 2.7 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family G-7-MTase PF12803.7 PIK53935.1 - 0.11 11.7 0.0 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) HSP70 PF00012.20 PIK53935.1 - 0.2 9.8 16.2 0.38 8.9 16.2 1.3 1 0 0 1 1 1 0 Hsp70 protein SecD-TM1 PF13721.6 PIK53935.1 - 7.5 7.1 15.4 0.18 12.3 2.2 3.1 2 1 1 3 3 3 0 SecD export protein N-terminal TM region ZU5 PF00791.20 PIK53936.1 - 1.7e-15 57.1 0.1 1.9e-07 31.4 0.1 2.6 2 0 0 2 2 2 2 ZU5 domain Death PF00531.22 PIK53936.1 - 1.4e-13 50.8 1.8 4.8e-07 29.9 0.4 2.7 2 0 0 2 2 2 2 Death domain LRR_8 PF13855.6 PIK53936.1 - 1.6e-10 40.5 2.8 6.8e-08 32.2 4.7 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK53936.1 - 6.3e-06 26.4 8.2 0.027 14.9 0.0 3.8 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK53936.1 - 0.0026 18.1 4.7 5 8.1 0.1 5.2 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 PIK53936.1 - 0.027 14.5 4.2 14 6.0 0.6 4.6 5 0 0 5 5 5 0 Leucine Rich repeat Calcipressin PF04847.12 PIK53936.1 - 0.18 11.6 1.3 0.43 10.3 1.3 1.6 1 0 0 1 1 1 0 Calcipressin Nop PF01798.18 PIK53937.1 - 1.5e-77 260.2 0.1 2.3e-77 259.5 0.1 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 PIK53937.1 - 3.5e-45 153.8 3.6 9.2e-45 152.4 3.6 1.7 1 0 0 1 1 1 1 Prp31 C terminal domain HHH_2 PF12826.7 PIK53937.1 - 0.0097 16.0 0.6 8.2 6.6 0.0 3.5 3 0 0 3 3 3 1 Helix-hairpin-helix motif MRP-S34 PF16053.5 PIK53938.1 - 2.9e-39 133.7 0.3 3.8e-39 133.3 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 Ank_2 PF12796.7 PIK53939.1 - 1.1e-26 93.2 0.0 2e-17 63.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK53939.1 - 2.1e-23 82.3 0.7 4.4e-15 55.8 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK53939.1 - 4.4e-18 65.1 0.1 5.5e-09 36.1 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK53939.1 - 4e-17 61.8 0.8 4.5e-07 30.0 0.2 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK53939.1 - 6.5e-14 50.7 0.2 1.6e-05 24.9 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Filamin PF00630.19 PIK53940.1 - 0.019 15.8 0.0 0.052 14.4 0.0 1.8 1 0 0 1 1 1 0 Filamin/ABP280 repeat TUG-UBL1 PF11470.8 PIK53941.1 - 3.3e-22 78.5 0.0 6.9e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 PIK53941.1 - 3e-13 49.8 0.2 2.1e-09 37.4 0.1 2.7 2 0 0 2 2 2 2 UBX domain RBD PF02196.15 PIK53941.1 - 0.00014 21.9 0.1 0.00062 19.8 0.0 2.0 2 0 0 2 2 2 1 Raf-like Ras-binding domain ubiquitin PF00240.23 PIK53941.1 - 0.0012 18.6 0.0 0.0032 17.2 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family THAP PF05485.12 PIK53942.1 - 1.2e-10 42.2 2.3 6.5e-10 39.8 2.3 2.4 1 0 0 1 1 1 1 THAP domain Peptidase_S49 PF01343.18 PIK53942.1 - 0.011 15.6 15.1 4.3 7.3 0.1 6.0 4 2 1 6 6 6 0 Peptidase family S49 Halo_GVPC PF05465.13 PIK53942.1 - 0.016 15.4 0.2 56 4.1 0.0 4.8 5 0 0 5 5 5 0 Halobacterial gas vesicle protein C (GVPC) repeat MCPsignal PF00015.21 PIK53942.1 - 0.023 14.5 5.0 1.5 8.6 2.6 3.2 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain zf-C2H2_11 PF16622.5 PIK53942.1 - 0.092 12.5 0.6 0.17 11.7 0.6 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type Stirrup PF09061.6 PIK53942.1 - 0.098 12.9 0.2 0.49 10.6 0.2 2.3 1 0 0 1 1 1 0 Stirrup FUSC PF04632.12 PIK53942.1 - 4.2 5.8 5.4 3.6 6.0 0.1 2.7 3 1 0 3 3 3 0 Fusaric acid resistance protein family TarH PF02203.15 PIK53942.1 - 9 6.2 11.4 7.3 6.5 0.6 4.4 1 1 1 4 4 4 0 Tar ligand binding domain homologue TSP_1 PF00090.19 PIK53943.1 - 1.6e-21 76.3 28.5 3e-16 59.4 10.0 2.7 2 0 0 2 2 2 2 Thrombospondin type 1 domain Laminin_G_2 PF02210.24 PIK53943.1 - 6.9e-13 49.3 0.0 8e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK53943.1 - 3.8e-06 27.2 0.0 0.005 17.0 0.0 2.5 2 0 0 2 2 2 2 Laminin G domain Exo70 PF03081.15 PIK53944.1 - 1.8e-82 277.4 9.2 1.9e-82 277.3 7.3 1.8 2 0 0 2 2 2 1 Exo70 exocyst complex subunit PRAI PF00697.22 PIK53944.1 - 0.012 15.4 0.1 0.041 13.7 0.0 1.9 2 0 0 2 2 2 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase N_Asn_amidohyd PF14736.6 PIK53945.1 - 4e-93 311.5 0.0 5.1e-93 311.1 0.0 1.0 1 0 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase 2OG-FeII_Oxy_3 PF13640.6 PIK53946.1 - 1.1e-10 42.3 0.1 2e-10 41.4 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 PIK53946.1 - 0.00038 20.0 0.1 0.0056 16.2 0.1 2.2 1 1 1 2 2 2 1 Oxygenase, catalysing oxidative methylation of damaged DNA Thioredoxin PF00085.20 PIK53947.1 - 9e-65 215.1 1.1 2.9e-30 104.3 0.1 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 PIK53947.1 - 4.7e-46 157.0 10.2 1.2e-35 123.1 4.2 3.7 2 2 2 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 PIK53947.1 - 3.8e-11 43.4 5.3 0.00031 21.2 0.1 4.5 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK53947.1 - 1.6e-10 41.2 1.0 0.0004 20.7 0.1 4.5 3 1 1 4 4 4 2 Thioredoxin-like OST3_OST6 PF04756.13 PIK53947.1 - 4.2e-09 36.2 0.0 0.0005 19.5 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 PIK53947.1 - 1.1e-07 31.9 0.0 0.023 14.9 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 PIK53947.1 - 8.8e-07 28.9 0.4 0.066 13.1 0.0 3.2 3 1 1 4 4 4 2 AhpC/TSA family Redoxin PF08534.10 PIK53947.1 - 6.6e-05 22.7 0.2 0.048 13.4 0.1 2.9 2 0 0 2 2 2 2 Redoxin TraF PF13728.6 PIK53947.1 - 0.00042 20.2 0.0 0.017 15.0 0.0 2.6 2 0 0 2 2 2 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 PIK53947.1 - 0.0031 17.7 2.2 0.51 10.6 0.1 3.4 2 1 0 2 2 2 1 Glutaredoxin HyaE PF07449.11 PIK53947.1 - 0.0083 16.1 0.0 2.1 8.3 0.0 2.8 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.6 PIK53947.1 - 0.0098 16.1 0.6 1 9.5 0.2 2.9 2 1 0 2 2 2 1 Thioredoxin DUF4170 PF13773.6 PIK53947.1 - 0.011 15.9 0.8 0.2 11.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4170) ERp29_N PF07912.13 PIK53947.1 - 0.037 14.2 6.9 2.5 8.3 0.1 4.5 4 3 0 4 4 4 0 ERp29, N-terminal domain NOA36 PF06524.12 PIK53947.1 - 0.093 12.0 1.2 0.16 11.2 1.2 1.4 1 0 0 1 1 1 0 NOA36 protein Exo_endo_phos_2 PF14529.6 PIK53948.1 - 3.8e-07 30.0 0.8 5e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase DUF600 PF04634.12 PIK53948.1 - 1.4 9.0 6.5 0.3 11.1 0.4 2.5 2 2 0 2 2 2 0 Protein of unknown function, DUF600 THAP PF05485.12 PIK53949.1 - 2.4e-08 34.8 0.0 4.4e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 THAP domain CENP-M PF11111.8 PIK53951.1 - 2.2e-22 79.1 0.2 2.5e-22 78.9 0.2 1.0 1 0 0 1 1 1 1 Centromere protein M (CENP-M) Sigma54_activat PF00158.26 PIK53951.1 - 0.072 12.8 0.0 0.078 12.7 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain 7tm_1 PF00001.21 PIK53952.1 - 3.2e-35 121.7 22.8 4e-35 121.4 22.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK53952.1 - 3.7e-07 29.8 23.9 4.8e-07 29.4 23.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK53952.1 - 5.9e-05 22.9 18.6 8.4e-05 22.4 18.6 1.3 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srw PF10324.9 PIK53952.1 - 0.00027 20.3 23.3 0.022 14.1 23.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK53952.1 - 0.018 14.7 29.0 0.078 12.6 28.9 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx TIMP PF00965.17 PIK53953.1 - 4.4e-13 49.4 4.8 7.5e-13 48.7 4.8 1.4 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase TIMP PF00965.17 PIK53954.1 - 7.8e-12 45.4 0.0 9.9e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase TIMP PF00965.17 PIK53955.1 - 6.5e-33 114.1 9.3 1.5e-23 83.6 3.4 2.1 2 0 0 2 2 2 2 Tissue inhibitor of metalloproteinase NTR PF01759.21 PIK53955.1 - 0.00035 20.4 1.1 0.85 9.5 0.2 2.4 2 0 0 2 2 2 2 UNC-6/NTR/C345C module EF-hand_1 PF00036.32 PIK53956.1 - 4.8e-08 32.0 0.7 3.7e-06 26.1 0.4 2.8 2 0 0 2 2 2 1 EF hand ZZ PF00569.17 PIK53956.1 - 9.9e-08 31.7 9.5 1.6e-07 31.0 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.6 PIK53956.1 - 1.7e-07 30.6 1.6 0.0001 21.9 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK53956.1 - 3.5e-06 27.4 0.7 0.0045 17.4 0.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK53956.1 - 6.1e-06 25.5 0.4 1.7e-05 24.1 0.4 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 PIK53956.1 - 8.8e-05 22.3 0.6 0.00071 19.4 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_4 PF12763.7 PIK53956.1 - 0.047 13.7 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand 7tm_1 PF00001.21 PIK53957.1 - 2.2e-43 148.5 2.6 3.1e-43 148.0 2.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK53957.1 - 1.2e-07 31.3 21.5 2.7e-05 23.7 11.8 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx SfLAP PF11139.8 PIK53957.1 - 0.0058 16.1 7.2 0.064 12.7 3.0 2.2 2 0 0 2 2 2 2 Sap, sulfolipid-1-addressing protein DUF2207 PF09972.9 PIK53957.1 - 0.34 9.6 9.4 0.19 10.5 0.6 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) MMACHC PF16690.5 PIK53958.1 - 4.2e-86 288.1 0.0 7.6e-86 287.2 0.0 1.4 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family Prefoldin PF02996.17 PIK53958.1 - 2.7e-18 66.0 0.5 4.3e-18 65.4 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 PIK53958.1 - 0.017 15.1 0.4 0.53 10.3 0.0 2.8 3 0 0 3 3 3 0 Prefoldin subunit ANAPC4_WD40 PF12894.7 PIK53959.1 - 7.9e-06 26.1 0.4 0.00025 21.3 0.1 2.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK53959.1 - 0.00015 22.5 0.7 0.0034 18.2 0.0 3.3 3 1 0 3 3 3 1 WD domain, G-beta repeat HPS3_N PF14761.6 PIK53959.1 - 0.00026 20.6 0.8 0.0078 15.8 0.0 2.2 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 PQQ_2 PF13360.6 PIK53959.1 - 0.027 14.0 0.0 0.06 12.9 0.0 1.6 1 1 0 1 1 1 0 PQQ-like domain DUF4062 PF13271.6 PIK53960.1 - 5.1e-13 49.2 0.0 7.3e-12 45.5 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) WD40 PF00400.32 PIK53960.1 - 6e-07 30.1 8.1 6.4e-06 26.8 0.1 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat AAA_16 PF13191.6 PIK53960.1 - 4.3e-05 24.0 0.1 0.00038 20.9 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK53960.1 - 0.014 15.7 0.0 0.41 10.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain ANAPC4_WD40 PF12894.7 PIK53960.1 - 0.026 14.8 0.2 0.21 11.9 0.1 2.6 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Torsin PF06309.11 PIK53960.1 - 0.027 14.6 0.0 0.078 13.1 0.0 1.7 1 0 0 1 1 1 0 Torsin Nup160 PF11715.8 PIK53960.1 - 0.042 12.5 0.2 0.23 10.0 0.1 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NACHT PF05729.12 PIK53960.1 - 0.057 13.3 0.1 1.8 8.5 0.1 2.7 1 1 1 2 2 2 0 NACHT domain Utp8 PF10395.9 PIK53960.1 - 0.11 10.9 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Utp8 family ATPase_2 PF01637.18 PIK53960.1 - 0.15 11.9 0.1 3.9 7.3 0.0 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 PIK53960.1 - 0.18 12.3 0.0 0.9 10.1 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 PIK53960.1 - 0.18 11.5 0.0 0.55 9.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain PPP4R2 PF09184.11 PIK53961.1 - 5.4e-53 180.5 35.0 8.1e-51 173.3 35.0 2.0 1 1 0 1 1 1 1 PPP4R2 Glyco_transf_10 PF00852.19 PIK53962.1 - 7.5e-53 178.9 0.2 1.3e-52 178.1 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK53962.1 - 1.7e-12 47.8 0.0 4.1e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Rad52_Rad22 PF04098.15 PIK53963.1 - 1.5e-46 158.1 0.0 3.4e-46 156.9 0.0 1.6 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein TFIIA PF03153.13 PIK53963.1 - 1.6 8.6 15.1 2.3 8.1 15.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF853 PF05872.12 PIK53963.1 - 2.1 6.8 5.7 3.2 6.2 5.7 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) BBS2_C PF14782.6 PIK53964.1 - 4.2e-62 210.3 6.9 4.6e-62 210.2 6.9 1.0 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal Sec5 PF15469.6 PIK53964.1 - 0.077 12.8 0.6 0.085 12.7 0.6 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec5 BBS2_C PF14782.6 PIK53965.1 - 8.5e-107 357.6 0.3 9.6e-106 354.1 0.0 2.3 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.6 PIK53965.1 - 1.9e-44 150.1 0.1 2.3e-43 146.7 0.0 2.4 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_N PF14781.6 PIK53965.1 - 1e-38 131.4 0.1 1.6e-37 127.6 0.0 2.8 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, N-terminal Itfg2 PF15907.5 PIK53965.1 - 0.0012 18.0 0.0 1.5 7.8 0.0 3.0 1 1 2 3 3 3 2 Integrin-alpha FG-GAP repeat-containing protein 2 FG-GAP PF01839.23 PIK53965.1 - 0.004 17.2 0.6 0.014 15.5 0.1 2.2 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 PIK53965.1 - 0.013 16.1 0.4 0.68 10.6 0.1 3.5 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella RIB43A PF05914.12 PIK53966.1 - 1.3e-146 488.2 60.8 1.4e-146 488.1 60.8 1.0 1 0 0 1 1 1 1 RIB43A CheX PF13690.6 PIK53966.1 - 0.2 11.9 0.1 0.82 9.9 0.1 2.2 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX DUF3715 PF12509.8 PIK53967.1 - 4.2e-32 111.2 0.0 1.3e-31 109.6 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) DUF4776 PF16003.5 PIK53967.1 - 0.015 14.3 0.3 0.015 14.3 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) LIN37 PF15306.6 PIK53968.1 - 5.8e-40 137.1 5.9 5.8e-40 137.1 5.9 1.7 1 1 1 2 2 2 1 LIN37 adh_short PF00106.25 PIK53969.1 - 3.3e-21 75.7 1.3 1.1e-19 70.7 0.2 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK53969.1 - 1e-19 71.1 0.2 1.8e-19 70.2 0.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK53969.1 - 0.078 12.9 0.5 12 5.8 0.0 2.2 2 0 0 2 2 2 0 KR domain Beach PF02138.18 PIK53970.1 - 1.6e-75 254.0 0.5 3.3e-75 253.0 0.5 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 PIK53970.1 - 7e-13 48.5 0.0 2.1e-12 47.0 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 PIK53970.1 - 0.0001 22.5 0.4 0.00036 20.7 0.4 1.9 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 PIK53970.1 - 0.0012 18.2 2.1 0.0025 17.2 2.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) Beach PF02138.18 PIK53971.1 - 8.2e-31 107.4 0.0 1.2e-30 106.9 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 PIK53971.1 - 1.1e-11 45.1 1.9 5.7e-06 27.0 0.1 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40_like PF17005.5 PIK53971.1 - 0.11 11.8 0.1 0.57 9.5 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain CHASE5 PF17149.4 PIK53971.1 - 0.14 12.1 0.1 0.85 9.6 0.1 2.1 2 0 0 2 2 2 0 Periplasmic sensor domain found in signal transduction proteins FYVE PF01363.21 PIK53972.1 - 2.9e-20 72.2 12.1 5.9e-20 71.2 12.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf_C2HC_14 PF18574.1 PIK53972.1 - 0.031 14.1 6.3 0.065 13.0 6.3 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain zf-AN1 PF01428.16 PIK53972.1 - 1.5 9.1 10.8 3.5 7.9 10.8 1.7 1 0 0 1 1 1 0 AN1-like Zinc finger FYVE_2 PF02318.16 PIK53972.1 - 1.7 8.9 12.9 0.26 11.5 8.6 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger 7tm_1 PF00001.21 PIK53973.1 - 1.7e-26 93.2 9.0 1.7e-26 93.2 9.0 2.0 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) Peptidase_M10 PF00413.24 PIK53974.1 - 8.8e-49 165.4 0.1 1.5e-48 164.7 0.1 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK53974.1 - 9.3e-24 83.1 19.0 3.5e-09 36.5 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 PIK53974.1 - 0.00039 20.6 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Peptidase_M57 PF12388.8 PIK53974.1 - 0.0033 17.1 0.1 0.0068 16.0 0.1 1.5 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 PIK53974.1 - 0.0034 17.4 0.1 0.0075 16.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M54 DUF4953 PF16313.5 PIK53974.1 - 0.017 14.4 0.2 0.028 13.6 0.2 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M66 PF10462.9 PIK53974.1 - 0.017 14.1 0.3 0.029 13.3 0.3 1.3 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 PIK53974.1 - 0.022 15.3 0.6 0.022 15.3 0.6 2.3 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK53974.1 - 0.041 14.0 0.6 0.041 14.0 0.6 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12 Metallopep PF12044.8 PIK53974.1 - 0.041 12.5 0.0 0.065 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family SIS PF01380.22 PIK53975.1 - 2e-57 192.7 0.1 1.4e-26 92.9 0.0 3.4 3 0 0 3 3 3 3 SIS domain GATase_6 PF13522.6 PIK53975.1 - 2.6e-16 60.1 0.0 5.2e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 PIK53975.1 - 5.3e-11 42.5 0.0 1.3e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain XH PF03469.14 PIK53975.1 - 0.013 15.4 0.2 0.47 10.3 0.1 2.4 2 0 0 2 2 2 0 XH domain GATase_4 PF13230.6 PIK53975.1 - 0.014 14.3 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferases class-II GATase_2 PF00310.21 PIK53975.1 - 0.024 13.4 0.0 0.063 12.0 0.0 1.6 1 1 1 2 2 2 0 Glutamine amidotransferases class-II CART PF06373.11 PIK53975.1 - 0.1 12.8 0.2 0.59 10.4 0.2 2.3 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) Skp1 PF01466.19 PIK53976.1 - 2e-27 95.1 0.4 2e-27 95.1 0.4 2.3 3 0 0 3 3 3 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 PIK53976.1 - 1e-26 92.8 0.2 2.6e-26 91.6 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain ATP-sulfurylase PF01747.17 PIK53977.1 - 2.5e-70 236.2 0.0 3.5e-70 235.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 PIK53977.1 - 5.7e-68 227.8 0.0 8.5e-68 227.2 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 PIK53977.1 - 3.4e-48 163.3 0.0 6.1e-48 162.5 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 PIK53977.1 - 2.3e-06 27.8 0.0 5.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK53977.1 - 0.00027 21.5 0.0 0.00066 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 PIK53977.1 - 0.023 14.4 0.0 0.075 12.8 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family 6PF2K PF01591.18 PIK53977.1 - 0.039 13.2 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase CbiA PF01656.23 PIK53977.1 - 0.08 13.0 0.0 0.096 12.7 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 PIK53977.1 - 0.092 12.4 0.0 1.7 8.3 0.0 2.4 1 1 1 2 2 2 0 Thymidylate kinase PEPCK_ATP PF01293.20 PIK53977.1 - 0.11 11.2 0.2 0.65 8.6 0.2 1.9 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase zf-MYND PF01753.18 PIK53978.1 - 1.3e-12 47.6 41.1 3.1e-10 39.9 16.3 3.0 3 0 0 3 3 3 2 MYND finger DUF4470 PF14737.6 PIK53978.1 - 8.1e-05 22.7 0.0 0.00021 21.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) ERAP1_C PF11838.8 PIK53979.1 - 6.7e-72 242.7 4.1 1.1e-71 242.0 4.1 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 PIK53979.1 - 4.8e-44 150.5 1.0 4.8e-44 150.5 1.0 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 PIK53980.1 - 4.8e-22 79.1 0.0 8.6e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 PIK53980.1 - 2.1e-15 56.9 0.1 2.8e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain SAPS PF04499.15 PIK53980.1 - 0.2 10.4 7.7 0.21 10.4 7.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 PIK53980.1 - 0.53 8.4 42.7 0.64 8.2 42.7 1.0 1 0 0 1 1 1 0 Nop14-like family LRR_8 PF13855.6 PIK53981.1 - 6.9e-36 121.8 13.7 1.9e-14 53.2 3.5 4.3 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK53981.1 - 9.3e-15 54.5 18.6 1.3e-07 31.8 0.3 4.7 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK53981.1 - 1.9e-13 50.5 0.4 1.7e-06 28.0 0.0 2.9 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK53981.1 - 3e-07 30.1 18.4 0.15 12.7 0.2 8.6 8 1 0 8 8 8 3 Leucine Rich Repeat TMEM154 PF15102.6 PIK53981.1 - 0.013 15.4 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family LRR_6 PF13516.6 PIK53981.1 - 0.025 14.6 20.7 3.6 7.9 0.3 6.8 8 0 0 8 8 8 0 Leucine Rich repeat RIFIN PF02009.16 PIK53981.1 - 0.045 13.6 0.0 0.059 13.3 0.0 1.1 1 0 0 1 1 1 0 Rifin CcmD PF04995.14 PIK53981.1 - 0.37 10.9 1.3 0.67 10.1 1.3 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Death PF00531.22 PIK53982.1 - 1.4e-16 60.4 1.0 2.4e-15 56.4 0.2 2.2 2 0 0 2 2 2 1 Death domain DED PF01335.21 PIK53982.1 - 3e-07 30.6 1.7 8.9e-07 29.1 0.9 2.0 2 0 0 2 2 2 1 Death effector domain DbpA PF03880.15 PIK53982.1 - 0.066 13.2 0.2 0.16 11.9 0.2 1.7 1 0 0 1 1 1 0 DbpA RNA binding domain SRCR PF00530.18 PIK53983.1 - 1.4e-09 38.3 0.1 2.3e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain NOA36 PF06524.12 PIK53983.1 - 0.018 14.4 3.7 0.025 13.9 3.7 1.1 1 0 0 1 1 1 0 NOA36 protein DUF3073 PF11273.8 PIK53983.1 - 0.019 15.7 1.4 0.036 14.8 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) SRCR_2 PF15494.6 PIK53983.1 - 0.047 14.2 0.1 0.12 12.9 0.1 1.6 2 0 0 2 2 2 0 Scavenger receptor cysteine-rich domain Utp14 PF04615.13 PIK53983.1 - 0.051 12.2 3.1 0.053 12.1 3.1 1.1 1 0 0 1 1 1 0 Utp14 protein Cwf_Cwc_15 PF04889.12 PIK53983.1 - 0.055 13.2 5.5 0.07 12.8 5.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3246 PF11596.8 PIK53983.1 - 0.2 11.1 1.5 0.24 10.8 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) FAM176 PF14851.6 PIK53983.1 - 0.83 9.3 5.7 2.1 8.0 5.7 1.8 1 1 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 PIK53983.1 - 1.4 6.9 3.8 1.5 6.8 3.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Kringle PF00051.18 PIK53984.1 - 2.9e-38 130.0 12.2 2.2e-21 76.0 0.8 3.1 1 1 2 3 3 3 2 Kringle domain SRCR PF00530.18 PIK53984.1 - 6.5e-06 26.6 2.5 6.5e-06 26.6 2.5 2.0 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Toxin_5 PF05294.13 PIK53984.1 - 0.98 9.9 5.3 1.7 9.1 2.6 2.9 2 1 0 2 2 2 0 Scorpion short toxin SRCR PF00530.18 PIK53985.1 - 5.3e-29 100.7 1.0 5.3e-29 100.7 1.0 2.7 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Kringle PF00051.18 PIK53985.1 - 2.8e-18 66.0 4.0 9.6e-18 64.3 4.0 2.0 1 1 0 1 1 1 1 Kringle domain Ldl_recept_a PF00057.18 PIK53985.1 - 4.7e-16 58.7 36.8 1.5e-09 37.9 13.0 3.3 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A PAN_1 PF00024.26 PIK53985.1 - 5.1e-08 32.8 1.1 1.9e-07 30.9 1.1 2.1 1 0 0 1 1 1 1 PAN domain F5_F8_type_C PF00754.25 PIK53985.1 - 2.9e-07 30.6 0.0 6.4e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain SRCR_2 PF15494.6 PIK53985.1 - 3e-05 24.5 0.1 8.6e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK53985.1 - 0.0002 21.8 0.1 0.00059 20.3 0.1 1.7 1 0 0 1 1 1 1 Hepsin, SRCR domain 7tm_1 PF00001.21 PIK53986.1 - 6.6e-27 94.5 10.6 9.7e-27 93.9 10.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK53986.1 - 0.0015 17.9 21.6 0.0045 16.4 21.6 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx OSTbeta PF15048.6 PIK53986.1 - 0.11 12.7 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF4834 PF16118.5 PIK53986.1 - 0.16 12.9 5.8 0.53 11.3 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SRCR PF00530.18 PIK53987.1 - 8.4e-08 32.6 0.1 1.2e-07 32.1 0.1 1.2 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Defensin_1 PF00323.19 PIK53987.1 - 0.22 12.1 1.7 15 6.3 0.1 2.3 2 0 0 2 2 2 0 Mammalian defensin Trypsin PF00089.26 PIK53988.1 - 1.2e-25 90.6 0.8 1.3e-25 90.5 0.8 1.1 1 0 0 1 1 1 1 Trypsin UBX PF00789.20 PIK53989.1 - 0.00012 22.2 0.0 0.00019 21.5 0.0 1.3 1 0 0 1 1 1 1 UBX domain S-AdoMet_synt_C PF02773.16 PIK53990.1 - 9.9e-68 226.4 0.8 1.7e-67 225.7 0.1 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 PIK53990.1 - 2.4e-42 144.0 0.0 6.1e-42 142.7 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 PIK53990.1 - 8.5e-32 109.8 1.3 2.4e-31 108.3 1.3 1.7 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Calx-beta PF03160.14 PIK53991.1 - 6.3e-40 135.4 2.5 1.7e-16 60.2 0.1 3.9 3 0 0 3 3 3 3 Calx-beta domain Cadherin_3 PF16184.5 PIK53992.1 - 4.5e-208 677.0 38.7 7e-26 90.4 1.7 12.8 12 1 0 12 12 12 11 Cadherin-like Calx-beta PF03160.14 PIK53992.1 - 1.2e-48 163.4 7.1 7e-14 51.8 0.1 5.9 5 0 0 5 5 5 4 Calx-beta domain Cadherin_4 PF17803.1 PIK53992.1 - 3e-11 43.8 41.8 0.0086 16.7 0.7 10.7 10 1 0 10 10 10 4 Bacterial cadherin-like domain Big_9 PF17963.1 PIK53992.1 - 5.1e-07 30.3 58.1 0.038 14.7 2.9 12.7 11 4 0 11 11 11 5 Bacterial Ig domain VSP PF03302.13 PIK53993.1 - 1.5e-13 50.4 133.5 1.9e-06 27.0 12.3 8.3 1 1 6 7 7 7 7 Giardia variant-specific surface protein GF_recep_IV PF14843.6 PIK53993.1 - 2.9e-09 36.8 139.0 0.0023 17.8 11.4 6.6 1 1 6 7 7 7 7 Growth factor receptor domain IV Furin-like_2 PF15913.5 PIK53993.1 - 1.4e-08 34.9 130.5 0.00018 21.6 19.5 8.3 1 1 7 9 9 9 5 Furin-like repeat, cysteine-rich VWC PF00093.18 PIK53994.1 - 1.4e-48 163.0 134.2 7.9e-10 38.9 13.9 7.3 6 1 1 7 7 7 6 von Willebrand factor type C domain TILa PF12714.7 PIK53994.1 - 6.2e-06 26.1 111.7 0.0091 15.9 9.3 8.2 4 1 4 8 8 8 6 TILa domain CFC PF09443.10 PIK53994.1 - 0.016 15.1 81.9 0.12 12.3 4.1 8.0 8 0 0 8 8 8 0 Cripto_Frl-1_Cryptic (CFC) FerB PF08150.12 PIK53996.1 - 1.3e-27 96.2 0.0 2.6e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 FerB (NUC096) domain FerA PF08165.11 PIK53996.1 - 8.8e-16 57.6 0.1 1.9e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 FerA (NUC095) domain Pex24p PF06398.11 PIK53996.1 - 7.1e-06 25.3 10.6 0.0025 16.9 0.2 2.7 2 1 0 3 3 3 2 Integral peroxisomal membrane peroxin BLOC1_2 PF10046.9 PIK53996.1 - 0.1 12.9 1.0 0.22 11.8 0.3 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 C2 PF00168.30 PIK53997.1 - 1.4e-24 86.3 0.0 6e-17 61.8 0.0 4.3 3 1 1 4 4 4 3 C2 domain Ferlin_C PF16165.5 PIK53997.1 - 1.2e-19 70.8 0.1 2e-19 70.1 0.1 1.3 1 0 0 1 1 1 1 Ferlin C-terminus zf-MYND PF01753.18 PIK53997.1 - 0.13 12.4 0.4 0.33 11.1 0.4 1.7 1 0 0 1 1 1 0 MYND finger Synaptobrevin PF00957.21 PIK53997.1 - 1.2 9.0 4.7 2 8.3 4.7 1.3 1 0 0 1 1 1 0 Synaptobrevin LRR_4 PF12799.7 PIK53998.1 - 1.1e-08 35.2 21.9 1.5 9.3 0.0 8.2 7 2 1 8 8 8 5 Leucine Rich repeats (2 copies) DUF1699 PF08004.11 PIK53998.1 - 0.0012 18.5 0.2 1.1 8.9 0.0 3.7 2 1 1 4 4 4 2 Protein of unknown function (DUF1699) zf-Di19 PF05605.12 PIK53999.1 - 3.4e-21 75.3 1.3 5.6e-21 74.6 1.3 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 PIK53999.1 - 0.013 15.7 1.2 0.62 10.4 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon zf-C2H2 PF00096.26 PIK53999.1 - 0.016 15.7 0.1 0.016 15.7 0.1 2.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK53999.1 - 0.02 15.7 1.4 0.12 13.2 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Di19_C PF14571.6 PIK53999.1 - 0.027 15.0 0.7 0.027 15.0 0.7 2.5 3 1 0 3 3 3 0 Stress-induced protein Di19, C-terminal zf-H2C2_2 PF13465.6 PIK53999.1 - 0.039 14.4 3.8 6.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-Mss51 PF13824.6 PIK53999.1 - 0.13 12.4 1.5 9.5 6.4 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ribbon_3 PF13248.6 PIK53999.1 - 0.13 11.7 3.3 3.8 7.1 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-CHCC PF10276.9 PIK53999.1 - 0.37 10.9 0.1 0.37 10.9 0.1 1.6 2 0 0 2 2 1 0 Zinc-finger domain Spore_III_AB PF09548.10 PIK53999.1 - 0.4 10.8 2.2 0.76 9.9 2.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) CpXC PF14353.6 PIK53999.1 - 3.5 7.7 4.8 0.89 9.6 0.1 2.3 2 1 0 2 2 2 0 CpXC protein 5_nucleotid PF05761.14 PIK54000.1 - 3.3e-167 557.0 0.1 3.8e-167 556.8 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family Tmpp129 PF10272.9 PIK54001.1 - 1.4e-128 429.2 0.5 1.6e-128 429.0 0.5 1.0 1 0 0 1 1 1 1 Putative transmembrane protein precursor Trypsin_2 PF13365.6 PIK54002.1 - 2e-30 106.7 0.1 4e-30 105.7 0.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 PIK54002.1 - 1.4e-13 51.2 0.0 2.3e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 PIK54002.1 - 4.1e-10 39.9 0.2 9.8e-10 38.6 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK54002.1 - 4.9e-08 32.7 0.0 1.5e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.9 PIK54002.1 - 1.6e-06 27.1 0.6 0.015 13.9 0.0 2.1 2 0 0 2 2 2 2 Peptidase S46 PDZ PF00595.24 PIK54002.1 - 1.5e-05 25.3 0.0 4.4e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 PIK54002.1 - 0.019 14.9 0.4 0.084 12.9 0.1 2.1 2 0 0 2 2 2 0 Tricorn protease PDZ domain LSM PF01423.22 PIK54002.1 - 0.076 12.7 0.4 0.3 10.8 0.1 2.0 2 0 0 2 2 2 0 LSM domain Peptidase_S32 PF05579.13 PIK54002.1 - 0.092 11.9 0.2 5.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 LRR_8 PF13855.6 PIK54003.1 - 5e-21 74.2 5.3 4.4e-12 45.6 0.8 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK54003.1 - 4.4e-09 36.5 8.8 7.2e-05 23.1 0.3 3.6 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK54003.1 - 8.7e-06 25.6 4.1 4.3 8.3 0.0 5.1 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK54003.1 - 0.0026 17.3 0.8 0.01 15.3 0.4 2.1 1 1 1 2 2 2 1 Leucine-rich repeat ANAPC8 PF04049.13 PIK54004.1 - 2.3e-26 92.5 5.5 2.3e-26 92.5 5.5 3.3 2 2 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 PIK54004.1 - 1.1e-24 85.1 26.1 5.7e-08 32.3 0.0 8.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54004.1 - 1e-22 78.4 27.6 0.00014 21.7 0.0 9.7 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_8 PF13181.6 PIK54004.1 - 1.6e-18 65.3 23.8 3.8e-05 23.6 0.0 10.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK54004.1 - 4.3e-15 55.1 3.3 2.7e-08 33.3 0.1 4.0 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.6 PIK54004.1 - 9.5e-15 54.1 10.9 0.0046 17.7 0.0 8.5 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK54004.1 - 1.1e-12 47.0 12.4 0.15 12.1 0.0 8.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK54004.1 - 7.4e-10 39.2 12.0 0.0042 17.6 0.1 6.6 7 2 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK54004.1 - 3.6e-08 33.6 18.6 0.0021 18.3 0.7 6.4 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK54004.1 - 3.8e-08 33.8 13.4 0.00043 20.9 0.0 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK54004.1 - 1.4e-07 31.4 8.6 0.16 12.4 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK54004.1 - 1.6e-05 25.3 16.1 1.7 9.5 0.2 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK54004.1 - 0.00032 20.9 29.1 0.15 12.3 0.8 6.9 6 3 2 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK54004.1 - 0.019 15.1 0.0 0.056 13.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat ChAPs PF09295.10 PIK54004.1 - 0.11 11.5 2.4 0.35 9.8 0.7 2.2 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 PIK54004.1 - 0.41 10.6 13.8 8.1 6.5 0.2 6.1 9 0 0 9 9 9 0 Tetratricopeptide repeat TUDOR PF00567.24 PIK54005.1 - 5e-06 26.6 0.1 1e-05 25.6 0.0 1.6 2 0 0 2 2 2 1 Tudor domain V_ATPase_I PF01496.19 PIK54005.1 - 0.068 11.1 2.7 0.077 10.9 2.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TUDOR PF00567.24 PIK54006.1 - 4.7e-92 304.3 3.9 2.8e-19 69.3 0.0 6.6 6 0 0 6 6 6 6 Tudor domain RRM_1 PF00076.22 PIK54006.1 - 7.9e-12 44.8 0.0 1.8e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Agenet PF05641.12 PIK54006.1 - 8.4e-10 39.0 1.3 0.1 13.0 0.0 6.2 6 0 0 6 6 6 3 Agenet domain zf-MYND PF01753.18 PIK54006.1 - 2.1e-05 24.5 19.0 2.1e-05 24.5 19.0 2.8 2 0 0 2 2 2 1 MYND finger RRM_5 PF13893.6 PIK54006.1 - 0.0015 18.2 0.0 0.0055 16.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4537 PF15057.6 PIK54006.1 - 0.0031 17.5 0.0 11 6.1 0.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4537) zf-HIT PF04438.16 PIK54006.1 - 0.056 13.3 10.5 0.16 11.8 10.5 1.8 1 0 0 1 1 1 0 HIT zinc finger Tudor_FRX1 PF18336.1 PIK54006.1 - 0.15 12.0 0.0 0.81 9.7 0.0 2.3 2 0 0 2 2 2 0 Fragile X mental retardation Tudor domain Tudor_4 PF18358.1 PIK54006.1 - 0.3 10.7 4.4 8.5 6.1 0.0 3.8 5 0 0 5 5 5 0 Histone methyltransferase Tudor domain DUF5641 PF18701.1 PIK54008.1 - 1.4e-31 108.5 2.9 1.4e-31 108.5 2.9 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5641) Peptidase_A17 PF05380.13 PIK54008.1 - 4.3e-26 91.8 0.0 8.2e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK54008.1 - 9.9e-09 35.2 0.1 4.1e-08 33.2 0.1 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK54008.1 - 1.7e-08 34.7 0.0 4.1e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain VEK-30 PF12107.8 PIK54008.1 - 0.48 10.4 1.5 30 4.7 0.4 2.8 2 0 0 2 2 2 0 Plasminogen (Pg) ligand in fibrinolytic pathway TIL PF01826.17 PIK54009.1 - 2.9e-06 27.4 16.7 2.9e-06 27.4 16.7 1.8 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain DUF4390 PF14334.6 PIK54009.1 - 0.037 13.4 0.0 7.1 6.0 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4390) CCDC71L PF15374.6 PIK54009.1 - 0.057 12.7 3.6 0.078 12.2 3.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L H_PPase PF03030.16 PIK54009.1 - 0.45 9.1 2.0 0.54 8.8 2.0 1.0 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF5008 PF16400.5 PIK54009.1 - 4.3 7.5 6.5 16 5.6 0.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5008) DNA_pol_A_exo1 PF01612.20 PIK54010.1 - 5.6e-12 45.7 0.0 1.4e-11 44.4 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease PCI PF01399.27 PIK54011.1 - 2.6e-11 44.0 0.0 2.6e-11 44.0 0.0 3.4 4 0 0 4 4 4 1 PCI domain GrpE PF01025.19 PIK54012.1 - 9.7e-47 158.7 5.9 1.2e-46 158.4 5.9 1.1 1 0 0 1 1 1 1 GrpE Connexin PF00029.19 PIK54012.1 - 0.073 12.8 0.2 0.097 12.4 0.2 1.1 1 0 0 1 1 1 0 Connexin DUF4381 PF14316.6 PIK54012.1 - 0.088 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) RBP_receptor PF14752.6 PIK54012.1 - 0.11 11.1 0.4 0.17 10.4 0.4 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor DUF2681 PF10883.8 PIK54012.1 - 0.13 12.6 2.7 0.31 11.5 2.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Mei5 PF10376.9 PIK54012.1 - 4.5 7.1 14.5 1.9 8.3 8.7 2.1 1 1 1 2 2 2 0 Double-strand recombination repair protein KMP11 PF03037.16 PIK54012.1 - 4.7 8.1 8.8 0.33 11.8 2.6 2.2 2 1 1 3 3 3 0 Kinetoplastid membrane protein 11 NdhM PF10664.9 PIK54013.1 - 1.2 9.4 6.5 0.46 10.8 0.3 3.2 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M Uteroglobin PF01099.17 PIK54013.1 - 1.3 9.4 6.2 11 6.4 0.8 3.5 3 0 0 3 3 3 0 Uteroglobin family DUF4407 PF14362.6 PIK54013.1 - 7.4 5.8 35.1 0.58 9.5 6.1 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 PIK54014.1 - 6 6.9 85.0 0.48 10.4 29.9 5.0 2 2 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WD40_alt PF14077.6 PIK54015.1 - 0.03 14.2 0.2 0.03 14.2 0.2 3.3 3 0 0 3 3 3 0 Alternative WD40 repeat motif Tropomyosin_1 PF12718.7 PIK54015.1 - 0.29 11.3 18.9 0.32 11.2 9.3 2.3 2 0 0 2 2 2 0 Tropomyosin like SKA1 PF07160.12 PIK54015.1 - 0.6 9.9 8.5 1.9 8.3 0.3 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Yuri_gagarin PF15934.5 PIK54015.1 - 1.4 8.7 12.8 0.5 10.2 4.0 2.1 2 0 0 2 2 2 0 Yuri gagarin CENP-F_leu_zip PF10473.9 PIK54015.1 - 6.1 6.9 29.5 6.4 6.8 15.6 3.1 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSC22 PF01166.18 PIK54015.1 - 6.7 7.1 14.0 1.4 9.3 1.8 3.8 3 1 0 3 3 3 0 TSC-22/dip/bun family PI3K_P85_iSH2 PF16454.5 PIK54016.1 - 0.012 15.2 9.6 0.48 10.0 2.8 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DHR10 PF18595.1 PIK54016.1 - 0.22 11.6 9.8 1.8 8.7 0.3 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Uds1 PF15456.6 PIK54016.1 - 0.67 10.1 7.7 3.5 7.8 7.6 2.0 1 1 0 1 1 1 0 Up-regulated During Septation DUF4763 PF15960.5 PIK54016.1 - 1.6 8.0 11.9 7.6 5.8 6.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Prominin PF05478.11 PIK54016.1 - 4.4 5.1 5.6 8.1 4.3 5.6 1.4 1 1 0 1 1 1 0 Prominin PCRF PF03462.18 PIK54016.1 - 5.4 6.8 10.9 0.25 11.2 2.0 2.2 1 1 1 2 2 2 0 PCRF domain DUF4527 PF15030.6 PIK54017.1 - 0.0015 18.0 0.3 0.0015 18.0 0.3 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF4527) UPF0242 PF06785.11 PIK54017.1 - 0.0044 17.1 15.9 0.0044 17.1 15.9 3.2 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 PIK54017.1 - 0.022 15.0 6.0 0.022 15.0 6.0 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) SH3_2 PF07653.17 PIK54018.1 - 0.038 13.7 0.0 0.79 9.4 0.0 2.2 2 1 0 2 2 2 0 Variant SH3 domain SH3_9 PF14604.6 PIK54018.1 - 0.13 12.2 0.0 0.61 10.0 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain KASH_CCD PF14662.6 PIK54019.1 - 0.02 14.7 1.8 0.05 13.4 0.5 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH BRE1 PF08647.11 PIK54019.1 - 0.87 9.7 4.9 4.4 7.4 0.9 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Neur_chan_memb PF02932.16 PIK54020.1 - 6.7e-50 170.4 0.2 8.7e-50 170.0 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK54020.1 - 7.9e-27 94.1 0.1 1.2e-26 93.5 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain 7TMR-DISM_7TM PF07695.11 PIK54020.1 - 0.017 15.0 5.9 0.017 15.0 5.9 1.9 2 0 0 2 2 2 0 7TM diverse intracellular signalling YhhN PF07947.14 PIK54020.1 - 0.4 10.3 8.8 0.022 14.4 2.8 1.8 2 0 0 2 2 2 0 YhhN family I-set PF07679.16 PIK54021.1 - 9.2e-34 115.4 0.0 5.6e-12 45.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54021.1 - 5e-30 103.9 0.0 6.2e-12 46.0 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK54021.1 - 9.1e-27 93.1 0.4 2e-10 40.7 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK54021.1 - 7.9e-21 74.2 0.3 2.3e-09 37.4 0.0 4.9 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK54021.1 - 3.8e-14 52.8 0.0 0.0022 18.2 0.0 4.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK54021.1 - 5.2e-08 32.3 0.0 0.25 11.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_4 PF16680.5 PIK54021.1 - 1.8e-06 28.1 0.0 0.58 10.5 0.0 3.8 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK54021.1 - 1e-05 25.5 1.0 0.0075 16.3 0.0 3.8 4 1 1 5 5 4 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK54021.1 - 6.3e-05 23.3 0.0 0.62 10.5 0.0 4.0 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Receptor_2B4 PF11465.8 PIK54021.1 - 0.00087 19.5 0.0 0.32 11.2 0.0 3.0 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 Cadherin_C_2 PF16492.5 PIK54021.1 - 0.022 15.5 0.2 0.055 14.2 0.2 1.6 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 PIK54021.1 - 0.053 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Herpes_gE PF02480.16 PIK54021.1 - 0.078 11.7 0.0 41 2.8 0.0 3.3 3 1 0 3 3 3 0 Alphaherpesvirus glycoprotein E FAM176 PF14851.6 PIK54021.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 FAM176 family RPEL PF02755.15 PIK54022.1 - 2.7e-12 45.9 14.0 4e-05 23.2 0.8 3.9 4 0 0 4 4 4 3 RPEL repeat SAP PF02037.27 PIK54022.1 - 3.7e-12 45.7 0.2 7.6e-12 44.7 0.2 1.6 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.6 PIK54022.1 - 0.088 12.5 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Telomere stability C-terminal TMEM252 PF15664.5 PIK54023.1 - 0.087 12.5 0.1 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 Transmembrane protein 252 family SBE2 PF17076.5 PIK54023.1 - 0.96 7.6 3.8 1.3 7.1 3.8 1.1 1 0 0 1 1 1 0 SBE2, cell-wall formation Cullin_binding PF03556.15 PIK54024.1 - 2.9e-31 108.4 0.0 4e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Cullin binding B3 PF02362.21 PIK54024.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 B3 DNA binding domain Baculo_E56 PF04639.12 PIK54025.1 - 0.0099 15.2 0.1 1.6 7.9 0.1 2.0 1 1 1 2 2 2 2 Baculoviral E56 protein, specific to ODV envelope DUF5641 PF18701.1 PIK54025.1 - 0.056 13.6 0.2 0.094 12.9 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5641) PP2C PF00481.21 PIK54026.1 - 3.6e-19 69.4 0.1 3.5e-15 56.3 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 PIK54026.1 - 0.0031 17.2 0.0 0.0039 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 PIK54027.1 - 0.0014 18.3 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Rho_GDI PF02115.17 PIK54029.1 - 2.6e-64 216.6 0.1 3.1e-64 216.3 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor RRM_1 PF00076.22 PIK54030.1 - 1.8e-11 43.7 0.0 2.8e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 PIK54030.1 - 0.00018 22.0 4.6 0.00018 22.0 4.6 3.8 2 2 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Tektin PF03148.14 PIK54031.1 - 1.4e-118 396.0 29.0 8.7e-81 271.6 20.5 2.0 2 0 0 2 2 2 2 Tektin family DUF4359 PF14271.6 PIK54031.1 - 0.014 16.1 2.2 0.057 14.2 2.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4359) DUF1664 PF07889.12 PIK54031.1 - 1.2 9.2 11.4 8.1 6.5 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) COG2 PF06148.11 PIK54031.1 - 6.4 6.9 7.8 31 4.7 0.1 3.6 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 NDUFB10 PF10249.9 PIK54032.1 - 4e-30 104.9 3.6 5.2e-30 104.5 3.6 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 Ribosomal_L3 PF00297.22 PIK54033.1 - 4.7e-169 562.2 9.9 4e-168 559.1 9.9 1.9 1 1 0 1 1 1 1 Ribosomal protein L3 FMN_dh PF01070.18 PIK54033.1 - 0.041 12.9 0.3 0.073 12.1 0.3 1.4 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Integrase_H2C2 PF17921.1 PIK54034.1 - 4.3e-24 84.4 0.7 1.3e-23 82.8 0.0 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK54034.1 - 2.4e-18 66.5 0.0 6.1e-18 65.1 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 PIK54034.1 - 1.3e-05 25.0 1.8 1.3e-05 25.0 1.8 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 PIK54034.1 - 0.00013 22.1 0.0 0.00028 21.1 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK54034.1 - 0.03 14.1 0.2 0.17 11.7 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain Glutaredoxin PF00462.24 PIK54034.1 - 0.068 13.4 0.3 0.42 10.9 0.0 2.5 3 0 0 3 3 3 0 Glutaredoxin OCD_Mu_crystall PF02423.15 PIK54035.1 - 3.6e-73 246.3 0.1 2.8e-55 187.5 0.0 2.0 2 0 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 PIK54035.1 - 3.8e-07 30.3 0.0 7.1e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 PIK54035.1 - 0.00027 21.5 0.0 0.00063 20.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 PIK54035.1 - 0.0011 19.8 0.1 0.002 18.9 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_2 PF03446.15 PIK54035.1 - 0.0027 17.9 0.6 0.0087 16.2 0.0 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase WD40 PF00400.32 PIK54037.1 - 1.6e-16 60.4 12.7 5.9e-06 26.9 0.4 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK54037.1 - 9.7e-09 35.4 1.4 0.0052 17.1 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK54037.1 - 0.0056 16.6 6.0 0.51 10.2 0.1 3.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Rhodanese PF00581.20 PIK54038.1 - 1.2e-17 64.4 0.0 2.1e-15 57.1 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Rhodanese PF00581.20 PIK54039.1 - 6e-25 87.8 0.0 3.6e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain APG12 PF04110.13 PIK54040.1 - 2.4e-24 85.6 0.0 4.9e-24 84.6 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 PIK54040.1 - 1.9e-07 31.2 0.0 4.4e-07 30.0 0.0 1.5 1 1 1 2 2 2 1 Autophagy protein Atg8 ubiquitin like NAR2 PF16974.5 PIK54040.1 - 0.086 12.2 0.6 0.14 11.6 0.6 1.4 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory WD40 PF00400.32 PIK54041.1 - 5.5e-42 141.0 21.5 0.00034 21.3 0.0 12.3 13 0 0 13 13 13 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK54041.1 - 1e-15 57.8 2.1 0.42 10.9 0.0 9.0 1 1 10 12 12 12 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK54041.1 - 2.8e-06 27.4 0.9 1.7 8.5 0.0 3.8 2 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 PIK54041.1 - 0.0001 22.0 0.0 0.0043 16.7 0.0 2.8 3 0 0 3 3 3 1 PQQ-like domain DAGK_cat PF00781.24 PIK54041.1 - 0.012 15.3 0.3 8 6.1 0.1 3.4 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain TPR_19 PF14559.6 PIK54042.1 - 2.2e-17 63.3 10.8 0.00054 20.4 0.0 7.3 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54042.1 - 1.1e-15 56.4 21.0 0.0011 18.9 0.1 9.9 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK54042.1 - 2.1e-11 44.0 11.9 0.032 14.5 0.8 8.3 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK54042.1 - 7.2e-11 41.4 23.2 0.0036 17.1 0.2 9.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK54042.1 - 1.2e-09 37.5 8.0 0.13 12.3 0.2 7.8 8 1 1 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK54042.1 - 1.3e-09 38.1 13.9 0.0017 18.6 2.6 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 PIK54042.1 - 2.3e-07 31.0 0.3 0.35 11.8 0.0 6.9 6 2 2 8 8 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK54042.1 - 6.6e-07 29.6 12.1 0.031 14.9 0.0 7.2 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK54042.1 - 1.2e-06 29.0 0.4 2.8 8.7 0.0 5.3 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK54042.1 - 1.7e-06 27.7 22.6 0.15 12.3 0.1 8.7 11 0 0 11 11 8 2 Tetratricopeptide repeat YfiO PF13525.6 PIK54042.1 - 0.005 16.6 1.5 0.005 16.6 1.5 2.8 3 0 0 3 3 3 1 Outer membrane lipoprotein HrpB1_HrpK PF09613.10 PIK54042.1 - 0.0076 15.9 0.3 5.3 6.7 0.0 4.2 4 1 0 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_9 PF13371.6 PIK54042.1 - 0.0082 16.3 0.5 7.1 6.9 0.0 3.6 3 1 1 4 4 3 1 Tetratricopeptide repeat DUF285 PF03382.14 PIK54042.1 - 0.035 13.9 0.3 0.068 12.9 0.3 1.4 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 COG2 PF06148.11 PIK54042.1 - 0.38 10.9 3.4 0.22 11.6 0.5 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Fis1_TPR_C PF14853.6 PIK54042.1 - 0.43 10.7 13.7 7.9 6.6 0.3 5.2 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 PIK54042.1 - 3.6 7.4 14.9 25 4.6 0.1 5.4 5 0 0 5 5 5 0 TPR repeat DUF4168 PF13767.6 PIK54042.1 - 4 8.7 9.4 0.54 11.5 0.6 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4168) DUF919 PF06034.11 PIK54042.1 - 7.1 6.5 7.3 0.32 10.9 1.3 1.9 2 0 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) PKD PF00801.20 PIK54043.1 - 9.7e-10 38.2 0.5 1.2e-06 28.3 0.0 3.3 3 1 0 3 3 3 2 PKD domain WD40 PF00400.32 PIK54044.1 - 2.5e-21 75.6 16.7 9.5e-06 26.3 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 PIK54044.1 - 5.1e-08 32.0 0.1 0.069 11.8 0.0 3.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 PIK54044.1 - 1.6e-06 28.3 0.6 1.8 8.9 0.0 5.1 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK54044.1 - 0.0078 15.6 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 WD40-like domain ParA PF10609.9 PIK54046.1 - 6.5e-104 346.7 0.0 7.4e-104 346.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 PIK54046.1 - 1.2e-13 51.3 0.0 9e-13 48.4 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 PIK54046.1 - 3.4e-09 36.4 0.0 9.4e-09 34.9 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 PIK54046.1 - 5.8e-09 36.1 2.3 1.1e-07 31.9 2.3 2.3 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 PIK54046.1 - 3.2e-07 29.8 0.5 1.6e-06 27.5 0.2 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 PIK54046.1 - 1.9e-06 27.9 0.5 0.018 14.8 0.0 3.0 2 1 1 3 3 3 2 AAA domain Fer4_NifH PF00142.18 PIK54046.1 - 6e-05 22.6 0.0 0.02 14.4 0.1 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MeaB PF03308.16 PIK54046.1 - 6.6e-05 22.0 0.2 0.0001 21.4 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 PIK54046.1 - 0.0002 21.3 0.0 0.00051 20.0 0.0 1.6 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_25 PF13481.6 PIK54046.1 - 0.00033 20.3 0.0 0.00048 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 PIK54046.1 - 0.00081 18.7 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 PIK54046.1 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK54046.1 - 0.0016 17.7 0.2 0.0028 16.9 0.2 1.3 1 0 0 1 1 1 1 NB-ARC domain NTPase_1 PF03266.15 PIK54046.1 - 0.0037 17.2 0.7 0.0081 16.1 0.7 1.5 1 0 0 1 1 1 1 NTPase RsgA_GTPase PF03193.16 PIK54046.1 - 0.0067 16.3 0.9 0.016 15.1 0.7 1.8 2 0 0 2 2 1 1 RsgA GTPase CBP_BcsQ PF06564.12 PIK54046.1 - 0.0093 15.5 0.0 0.023 14.2 0.0 1.7 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 PIK54046.1 - 0.011 15.4 0.2 0.038 13.6 0.2 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.12 PIK54046.1 - 0.014 15.3 0.6 0.029 14.3 0.6 1.5 1 0 0 1 1 1 0 NACHT domain KTI12 PF08433.10 PIK54046.1 - 0.018 14.5 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_22 PF13401.6 PIK54046.1 - 0.022 15.0 0.1 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain RP1-2 PF12042.8 PIK54046.1 - 0.027 14.4 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 Tubuliform egg casing silk strands structural domain IstB_IS21 PF01695.17 PIK54046.1 - 0.048 13.4 0.1 0.16 11.7 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein DnaB_C PF03796.15 PIK54046.1 - 0.055 12.8 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain DAP3 PF10236.9 PIK54046.1 - 0.065 12.4 0.2 0.14 11.3 0.3 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_30 PF13604.6 PIK54046.1 - 0.094 12.4 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 PIK54046.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 PIK54046.1 - 0.11 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 PIK54046.1 - 0.11 11.9 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 PIK54046.1 - 0.12 12.7 0.3 0.55 10.6 0.2 2.0 1 1 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 PIK54046.1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 PIK54046.1 - 0.13 12.8 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 PIK54046.1 - 0.16 11.9 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RAI1 PF08652.11 PIK54047.1 - 1e-25 89.7 1.8 1.2e-25 89.4 0.1 2.1 3 0 0 3 3 3 1 RAI1 like PD-(D/E)XK nuclease Ank_5 PF13857.6 PIK54048.1 - 2.8e-09 37.0 0.3 4.4e-08 33.2 0.2 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK54048.1 - 6.5e-09 36.3 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54048.1 - 8.7e-08 32.6 0.2 2.8e-06 27.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK54048.1 - 6.4e-07 29.5 0.0 0.00017 21.9 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat G-patch PF01585.23 PIK54048.1 - 4.1e-05 23.4 0.9 8.5e-05 22.4 0.9 1.6 1 0 0 1 1 1 1 G-patch domain Ank_3 PF13606.6 PIK54048.1 - 7.3e-05 22.9 0.1 0.00063 20.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Mcl1_mid PF12341.8 PIK54048.1 - 0.073 12.4 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region zf-PHD-like PF15446.6 PIK54048.1 - 0.075 12.6 0.5 0.15 11.6 0.5 1.6 1 1 0 1 1 1 0 PHD/FYVE-zinc-finger like domain zf-C2H2_jaz PF12171.8 PIK54048.1 - 0.075 13.3 2.2 0.075 13.3 2.2 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF5401 PF17380.2 PIK54050.1 - 0.0021 16.2 3.5 0.0021 16.2 3.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5401) MIase PF02426.16 PIK54050.1 - 0.16 12.1 1.5 0.22 11.7 1.5 1.2 1 0 0 1 1 1 0 Muconolactone delta-isomerase PI-PLC-Y PF00387.19 PIK54051.1 - 8.7e-26 90.5 0.1 3.3e-25 88.7 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 PIK54051.1 - 2.3e-12 47.1 0.0 5.7e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain JUPITER PF17054.5 PIK54051.1 - 0.032 13.7 0.1 0.071 12.6 0.1 1.6 2 0 0 2 2 2 0 Microtubule-Associated protein Jupiter PI-PLC-X PF00388.19 PIK54051.1 - 0.066 12.8 0.2 0.14 11.7 0.2 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Band_7 PF01145.25 PIK54054.1 - 1.2e-25 90.5 6.7 2.4e-25 89.6 6.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 PIK54054.1 - 0.0012 19.0 1.4 0.002 18.3 1.4 1.3 1 0 0 1 1 1 1 Mediator complex subunit 2 Cas6_N PF17952.1 PIK54054.1 - 0.17 12.1 0.4 1.4 9.2 0.1 2.1 2 0 0 2 2 2 0 Cas6 N-terminal domain Death PF00531.22 PIK54055.1 - 5.2e-09 36.2 0.5 9.5e-09 35.3 0.5 1.4 1 0 0 1 1 1 1 Death domain YqzH PF14164.6 PIK54055.1 - 0.036 14.1 0.4 0.077 13.1 0.4 1.5 1 0 0 1 1 1 0 YqzH-like protein ZU5 PF00791.20 PIK54056.1 - 1.4e-13 51.0 0.0 3.3e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK54056.1 - 5.2e-07 29.7 0.6 1e-06 28.8 0.6 1.5 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK54057.1 - 8.6e-14 51.7 0.0 2.8e-13 50.0 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain RT_RNaseH PF17917.1 PIK54057.1 - 2.5e-13 50.2 0.0 7e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK54057.1 - 4.4e-05 23.5 0.0 0.00017 21.5 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK54057.1 - 0.085 13.0 0.0 0.24 11.6 0.0 1.8 1 1 0 1 1 1 0 Integrase core domain EamA PF00892.20 PIK54058.1 - 1.3e-21 77.2 32.6 2e-13 50.7 14.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family Transgly_assoc PF04226.13 PIK54058.1 - 0.05 13.9 4.6 0.17 12.2 0.3 3.3 3 0 0 3 3 3 0 Transglycosylase associated protein DUF2452 PF10504.9 PIK54059.1 - 3.6e-69 231.2 0.0 4.3e-69 230.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) DUF2721 PF11026.8 PIK54059.1 - 0.047 13.6 0.1 0.08 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) HECT PF00632.25 PIK54060.1 - 4.1e-11 42.9 0.0 8.8e-10 38.5 0.0 2.4 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBX PF00789.20 PIK54060.1 - 3.2e-05 24.0 0.0 9.8e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 UBX domain rve PF00665.26 PIK54061.1 - 3.9e-05 23.8 0.0 7.3e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_7 PF02796.15 PIK54061.1 - 5e-05 23.3 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 PIK54061.1 - 0.023 14.4 0.0 0.064 13.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain TnsD PF15978.5 PIK54061.1 - 0.072 12.1 0.3 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Tn7-like transposition protein D GTP_CH_N PF12471.8 PIK54061.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal 7tm_1 PF00001.21 PIK54062.1 - 3.2e-24 85.7 3.9 3.6e-24 85.5 3.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK54062.1 - 0.00014 21.3 2.2 0.00017 21.1 2.2 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK54062.1 - 0.00019 21.2 6.8 0.00031 20.5 6.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4994 PF16385.5 PIK54063.1 - 2.9e-05 23.9 0.0 9.4e-05 22.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 PIK54063.1 - 9.6e-05 23.1 0.1 0.00031 21.5 0.0 1.8 2 0 0 2 2 2 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 PIK54063.1 - 0.009 15.4 0.1 0.21 11.0 0.1 2.1 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 PIK54063.1 - 0.012 15.8 0.2 0.031 14.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) CCDC84 PF14968.6 PIK54063.1 - 0.064 12.9 0.1 3.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Coiled coil protein 84 PDH PF02153.17 PIK54063.1 - 0.13 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase Sulfatase PF00884.23 PIK54064.1 - 2.3e-60 204.6 0.0 3.1e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF4994 PF16385.5 PIK54064.1 - 7.1e-05 22.7 0.0 0.00027 20.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 PIK54064.1 - 0.00014 22.6 0.0 0.00062 20.5 0.0 2.1 2 1 0 2 2 2 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK54064.1 - 0.086 12.4 0.0 0.91 9.0 0.0 2.2 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase BAR_3 PF16746.5 PIK54065.1 - 1.1e-54 185.6 7.2 1.1e-54 185.6 7.2 2.0 2 0 0 2 2 1 1 BAR domain of APPL family ArfGap PF01412.18 PIK54065.1 - 1.8e-36 124.7 2.7 1.8e-36 124.7 2.7 2.8 4 0 0 4 4 3 1 Putative GTPase activating protein for Arf PH PF00169.29 PIK54065.1 - 1e-14 54.9 0.1 1e-14 54.9 0.1 2.0 2 0 0 2 2 1 1 PH domain Ank_2 PF12796.7 PIK54065.1 - 9.7e-14 51.7 0.6 1.8e-07 31.6 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54065.1 - 8.3e-12 45.4 0.4 9.9e-07 29.2 0.1 3.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54065.1 - 4.4e-09 35.8 0.2 0.0021 18.4 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 PIK54065.1 - 3.4e-08 33.6 1.1 0.00067 19.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK54065.1 - 4.9e-08 33.1 1.8 0.036 14.5 0.1 4.5 4 0 0 4 4 4 2 Ankyrin repeat BAR PF03114.18 PIK54065.1 - 7.1e-06 25.8 2.2 7.1e-06 25.8 2.2 1.9 2 0 0 2 2 1 1 BAR domain zf-B_box PF00643.24 PIK54065.1 - 0.016 15.3 0.6 0.037 14.2 0.6 1.6 1 0 0 1 1 1 0 B-box zinc finger ZnuA PF01297.17 PIK54065.1 - 0.052 13.0 0.4 0.15 11.4 0.4 1.7 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Baculo_PEP_C PF04513.12 PIK54065.1 - 0.058 13.4 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Band_3_cyto PF07565.13 PIK54065.1 - 0.068 13.0 0.5 2.9 7.6 0.1 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain PH_11 PF15413.6 PIK54065.1 - 0.39 11.2 12.0 0.067 13.6 2.6 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain EGF PF00008.27 PIK54066.1 - 2.2e-37 127.0 82.0 1.8e-09 37.7 11.8 6.8 6 1 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK54066.1 - 6e-22 77.5 70.3 1.8e-08 34.7 7.2 8.2 7 2 0 7 7 7 6 Human growth factor-like EGF EGF_2 PF07974.13 PIK54066.1 - 2.5e-09 37.3 93.1 0.01 16.2 5.5 6.5 6 0 0 6 6 6 5 EGF-like domain EGF_CA PF07645.15 PIK54066.1 - 0.00014 22.0 12.6 0.00014 22.0 12.6 7.5 3 2 3 6 6 6 3 Calcium-binding EGF domain cEGF PF12662.7 PIK54066.1 - 0.00024 21.0 0.5 0.00024 21.0 0.5 9.2 8 3 0 8 8 8 3 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 PIK54066.1 - 0.024 14.9 5.7 0.024 14.9 5.7 6.3 5 1 1 6 6 6 0 Pvs28 EGF domain EGF_3 PF12947.7 PIK54066.1 - 0.032 14.4 10.8 0.032 14.4 10.8 7.3 5 1 1 6 6 6 0 EGF domain Pneumo_NS1 PF03438.13 PIK54066.1 - 0.069 13.3 2.4 0.18 11.9 2.3 1.8 1 1 0 1 1 1 0 Pneumovirus NS1 protein CEP76-C2 PF15627.6 PIK54066.1 - 0.097 12.2 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 CEP76 C2 domain FXa_inhibition PF14670.6 PIK54066.1 - 6.9 7.0 73.1 0.77 10.1 11.2 7.0 1 1 3 4 4 4 0 Coagulation Factor Xa inhibitory site Sushi PF00084.20 PIK54067.1 - 2.5e-20 72.8 35.8 9.6e-05 22.9 0.4 5.6 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) HYR PF02494.16 PIK54067.1 - 1.4e-16 60.5 1.9 5e-12 46.0 0.0 3.1 2 1 0 2 2 2 2 HYR domain HRM PF02793.22 PIK54067.1 - 0.75 10.1 29.3 0.19 12.0 0.9 5.6 5 2 1 6 6 6 0 Hormone receptor domain CreA PF05981.12 PIK54068.1 - 0.015 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 CreA protein DUF5388 PF17363.2 PIK54068.1 - 0.043 14.0 0.2 0.095 12.9 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5388) DUF1759 PF03564.15 PIK54069.1 - 0.00022 21.2 0.0 0.00039 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DivIVA PF05103.13 PIK54069.1 - 0.3 11.1 7.6 0.55 10.3 7.6 1.3 1 0 0 1 1 1 0 DivIVA protein RhoGAP PF00620.27 PIK54070.1 - 1.6e-47 161.2 0.0 2.1e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.11 PIK54070.1 - 0.05 12.8 0.0 0.064 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) KIP1 PF07765.12 PIK54071.1 - 0.24 11.5 3.0 0.38 10.9 0.1 2.5 2 0 0 2 2 2 0 KIP1-like protein DUF4205 PF13898.6 PIK54072.1 - 7.6e-127 423.0 0.0 9.6e-127 422.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) 7tm_2 PF00002.24 PIK54073.1 - 4.6e-70 235.7 18.9 6e-70 235.3 18.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 PIK54073.1 - 1.8e-14 53.7 4.7 4.3e-14 52.5 4.7 1.7 1 0 0 1 1 1 1 Hormone receptor domain Insulin_TMD PF17870.1 PIK54073.1 - 4.9 7.3 16.2 1.6 8.9 0.1 3.8 4 0 0 4 4 4 0 Insulin receptor trans-membrane segment DDE_Tnp_4 PF13359.6 PIK54074.1 - 1.7e-35 122.0 0.0 2.5e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK54074.1 - 1.4e-11 44.4 0.0 2.2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 PIK54074.1 - 0.0011 18.6 0.3 0.03 14.0 0.0 2.5 2 1 0 2 2 2 1 Transposase DDE domain REV PF00424.18 PIK54074.1 - 0.0063 16.5 3.4 0.0063 16.5 3.4 1.7 2 0 0 2 2 2 1 REV protein (anti-repression trans-activator protein) Cullin PF00888.22 PIK54076.1 - 9.1e-169 563.0 18.3 1.4e-168 562.3 18.3 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 PIK54076.1 - 1.7e-26 92.0 3.1 1.7e-26 92.0 3.1 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_20 PF12840.7 PIK54076.1 - 0.00022 21.2 0.0 0.0084 16.2 0.0 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain DUF2004 PF09406.10 PIK54076.1 - 0.02 15.2 1.8 0.095 13.0 0.3 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2004) ACDC PF14733.6 PIK54076.1 - 0.94 9.8 4.1 5.7 7.3 0.2 3.7 3 1 0 3 3 3 0 AP2-coincident C-terminal PDZ PF00595.24 PIK54077.1 - 4.4e-41 139.1 4.9 1.3e-14 54.3 0.2 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK54077.1 - 7.7e-19 67.3 0.2 2.7e-06 27.1 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK54077.1 - 1.2e-15 57.6 1.3 0.00084 19.6 0.0 3.7 3 0 0 3 3 3 3 PDZ domain Glycos_transf_2 PF00535.26 PIK54078.1 - 4.1e-30 104.8 0.0 7e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 PIK54078.1 - 1.4e-05 24.6 0.0 2.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 PIK54078.1 - 9.3e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 PIK54078.1 - 0.0052 16.3 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 PIK54079.1 - 3.1e-33 115.0 0.0 5.3e-33 114.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK54079.1 - 8.7e-14 51.9 0.9 1.6e-13 51.0 0.9 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 PIK54079.1 - 3.4e-07 29.8 0.0 6.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 PIK54079.1 - 4.3e-07 30.1 0.0 8.1e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 PIK54079.1 - 0.0019 17.8 0.0 0.0051 16.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 PIK54079.1 - 0.023 15.4 0.1 0.12 13.1 0.1 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 PIK54079.1 - 0.26 10.9 2.0 7 6.2 0.8 2.4 1 1 1 2 2 2 0 Cytolethal distending toxin A/C domain PIN_8 PF18476.1 PIK54080.1 - 0.0037 17.1 1.9 0.0046 16.9 1.9 1.0 1 0 0 1 1 1 1 PIN like domain BRCT PF00533.26 PIK54081.1 - 0.033 14.6 0.9 0.21 12.0 0.1 2.7 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain ODV-E18 PF10717.9 PIK54081.1 - 0.042 13.7 0.2 2.3 8.2 0.0 2.6 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF2059 PF09832.9 PIK54081.1 - 0.081 13.0 0.3 0.19 11.8 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) DUF5082 PF16888.5 PIK54082.1 - 3.5e-05 24.1 12.7 0.00048 20.4 5.5 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF5082) DUF4226 PF10774.9 PIK54082.1 - 0.058 13.7 3.7 0.12 12.6 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) RasGAP_C PF03836.15 PIK54082.1 - 0.1 12.8 15.7 0.091 12.9 3.8 2.3 1 1 1 2 2 2 0 RasGAP C-terminus DUF4404 PF14357.6 PIK54082.1 - 0.11 13.1 0.8 0.11 13.1 0.8 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) DUF1192 PF06698.11 PIK54082.1 - 0.15 12.1 0.5 0.15 12.1 0.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) SlyX PF04102.12 PIK54082.1 - 0.26 11.9 14.7 4.4 8.0 3.4 3.5 1 1 1 3 3 3 0 SlyX DUF2730 PF10805.8 PIK54082.1 - 0.32 11.1 9.0 3.9 7.6 4.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.12 PIK54082.1 - 0.34 10.9 2.8 1.9 8.5 0.9 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.6 PIK54082.1 - 0.67 10.4 12.9 0.47 10.9 6.9 2.6 1 1 1 3 3 3 0 Snapin/Pallidin CLZ PF16526.5 PIK54082.1 - 0.9 9.9 10.6 0.1 12.9 2.0 2.9 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ERM PF00769.19 PIK54082.1 - 1.1 9.1 28.5 7.1 6.4 28.3 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 PIK54082.1 - 1.1 8.7 26.8 0.23 10.9 16.4 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 HalX PF08663.10 PIK54082.1 - 1.3 9.4 11.4 1.5 9.2 0.9 3.8 2 1 1 3 3 3 0 HalX domain NPV_P10 PF05531.12 PIK54082.1 - 1.6 9.3 6.7 2.2 8.8 3.9 2.4 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.14 PIK54082.1 - 2.2 8.1 26.3 5.7 6.7 12.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 PIK54082.1 - 2.6 7.3 12.8 10 5.3 12.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 PIK54082.1 - 2.8 7.8 17.1 6.1 6.7 2.9 3.7 2 2 1 3 3 3 0 Septum formation initiator Prefoldin PF02996.17 PIK54082.1 - 3.5 7.6 15.7 0.25 11.3 1.9 3.1 2 1 1 3 3 3 0 Prefoldin subunit FAM76 PF16046.5 PIK54082.1 - 4.9 6.4 18.5 0.72 9.1 12.8 1.8 1 1 1 2 2 2 0 FAM76 protein Spc7 PF08317.11 PIK54082.1 - 5.1 5.9 29.6 0.9 8.4 11.6 2.3 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 PIK54082.1 - 6.5 6.8 11.9 12 5.9 5.8 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 PIK54082.1 - 6.8 7.4 27.1 5.8 7.6 5.7 3.4 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMPIT PF07851.13 PIK54082.1 - 7.1 5.8 18.3 1.3 8.3 7.8 2.2 1 1 1 2 2 2 0 TMPIT-like protein TPR_MLP1_2 PF07926.12 PIK54082.1 - 7.3 6.7 25.6 2 8.5 9.6 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FapA PF03961.13 PIK54082.1 - 7.3 5.1 18.6 4.9 5.6 10.1 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A TolA_bind_tri PF16331.5 PIK54082.1 - 7.6 6.7 12.3 1.3 9.2 3.6 3.0 3 1 0 3 3 3 0 TolA binding protein trimerisation PIP5K PF01504.18 PIK54083.1 - 5.6e-76 255.4 0.8 7.9e-76 254.9 0.8 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase IPK PF03770.16 PIK54084.1 - 1.4e-43 149.1 0.0 2.7e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase bVLRF1 PF18826.1 PIK54085.1 - 8.6e-34 116.6 7.7 3.8e-31 108.0 0.0 3.6 2 2 2 4 4 4 2 bacteroidetes VLRF1 release factor NodZ PF05830.11 PIK54085.1 - 0.058 12.2 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) BING4CT PF08149.11 PIK54086.1 - 1.7e-37 127.1 0.0 1.8e-36 123.8 0.0 2.4 2 0 0 2 2 2 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 PIK54086.1 - 9.8e-08 32.2 0.0 0.3 11.4 0.0 4.5 2 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK54086.1 - 0.0078 17.0 0.1 0.7 10.9 0.2 3.7 4 0 0 4 4 4 1 WD domain, G-beta repeat MerB PF03243.15 PIK54086.1 - 0.016 15.4 0.1 0.032 14.4 0.1 1.4 1 0 0 1 1 1 0 Alkylmercury lyase DUF4820 PF16091.5 PIK54086.1 - 4.2 6.7 7.8 8.3 5.7 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Anoctamin PF04547.12 PIK54087.1 - 9e-139 463.2 14.7 1.1e-138 462.9 14.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 PIK54087.1 - 5.4e-05 23.0 0.0 0.00013 21.7 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Pex2_Pex12 PF04757.14 PIK54087.1 - 0.063 12.9 1.3 5.2 6.6 1.8 2.7 1 1 1 2 2 2 0 Pex2 / Pex12 amino terminal region Clathrin-link PF09268.10 PIK54087.1 - 0.07 12.5 0.0 0.28 10.6 0.0 2.1 2 0 0 2 2 2 0 Clathrin, heavy-chain linker Glyco_hydro_35 PF01301.19 PIK54088.1 - 5.1e-113 377.9 0.0 6.3e-113 377.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 PIK54088.1 - 3.6e-14 52.9 0.1 1.9e-12 47.2 0.1 2.1 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 PIK54088.1 - 3.1e-06 27.8 0.1 0.00015 22.3 0.0 2.7 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain Kinesin PF00225.23 PIK54089.1 - 7.5e-96 320.9 0.0 1.7e-95 319.8 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK54089.1 - 5.6e-19 68.6 0.0 2.2e-18 66.6 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 PIK54089.1 - 6e-11 42.6 3.4 6.9e-11 42.4 0.6 2.7 2 0 0 2 2 2 1 Kinesin protein 1B Yop-YscD_cpl PF16697.5 PIK54089.1 - 0.0048 17.2 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Titin_Z PF09042.11 PIK54089.1 - 0.07 13.1 1.9 0.4 10.7 1.9 2.4 1 0 0 1 1 1 0 Titin Z C2 PF00168.30 PIK54089.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 C2 domain Kinesin_assoc PF16183.5 PIK54089.1 - 0.42 10.7 12.6 0.61 10.2 7.6 3.2 2 1 0 2 2 2 0 Kinesin-associated KLRAQ PF10205.9 PIK54089.1 - 1.4 9.2 13.9 0.3 11.3 8.7 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF87 PF01935.17 PIK54089.1 - 1.9 8.5 7.6 21 5.1 2.5 2.9 2 0 0 2 2 2 0 Helicase HerA, central domain ARID PF01388.21 PIK54090.1 - 1.7e-11 44.6 0.2 4.7e-11 43.2 0.0 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain zf-CW PF07496.15 PIK54090.1 - 3.5e-11 42.9 9.9 1e-10 41.4 9.9 1.9 1 0 0 1 1 1 1 CW-type Zinc Finger PWWP PF00855.17 PIK54090.1 - 5e-11 42.9 0.4 2.3e-10 40.8 0.4 2.2 1 0 0 1 1 1 1 PWWP domain LRR_8 PF13855.6 PIK54091.1 - 5.8e-49 163.7 43.9 9e-14 51.0 4.2 6.9 3 2 3 7 7 7 6 Leucine rich repeat LRR_5 PF13306.6 PIK54091.1 - 5.3e-23 81.4 0.9 9.4e-13 48.2 0.5 2.7 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK54091.1 - 7.5e-18 64.3 41.1 0.00026 21.3 1.9 8.7 3 2 5 11 11 11 8 Leucine Rich repeats (2 copies) I-set PF07679.16 PIK54091.1 - 3.7e-13 49.3 0.0 6.5e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54091.1 - 8.3e-11 42.3 0.0 3.3e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_9 PF14580.6 PIK54091.1 - 4e-08 33.0 20.9 0.0087 15.6 1.0 5.0 1 1 4 5 5 5 5 Leucine-rich repeat Ig_2 PF13895.6 PIK54091.1 - 4.5e-07 30.1 0.0 1.3e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 PIK54091.1 - 3.1e-05 23.9 25.6 11 7.1 0.3 10.9 12 0 0 12 12 11 1 Leucine Rich Repeat ig PF00047.25 PIK54091.1 - 0.0018 18.4 0.0 0.01 16.0 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK54091.1 - 0.025 14.1 0.0 0.065 12.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK54091.1 - 0.12 12.6 0.0 1 9.6 0.0 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.6 PIK54091.1 - 1.5 9.1 28.8 12 6.2 0.1 8.7 11 0 0 11 11 9 0 Leucine Rich repeat Y_phosphatase PF00102.27 PIK54092.1 - 5.3e-65 219.3 0.0 9.4e-65 218.5 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Receptor_IA-2 PF11548.8 PIK54092.1 - 7.8e-14 51.4 0.1 1.9e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase receptor IA-2 DSPc PF00782.20 PIK54092.1 - 0.0069 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CD34_antigen PF06365.12 PIK54092.1 - 0.013 15.1 0.1 0.033 13.7 0.1 1.7 1 0 0 1 1 1 0 CD34/Podocalyxin family Arc_PepC_II PF06847.11 PIK54092.1 - 0.035 14.6 0.1 0.11 13.0 0.1 1.8 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II DUF3377 PF11857.8 PIK54092.1 - 0.035 14.0 0.9 0.1 12.5 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Y_phosphatase3 PF13350.6 PIK54092.1 - 0.037 14.0 0.4 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Tyrosine phosphatase family SIT PF15330.6 PIK54092.1 - 0.041 14.3 0.2 0.1 13.1 0.2 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.6 PIK54092.1 - 0.043 13.7 0.2 0.043 13.7 0.2 1.9 2 0 0 2 2 2 0 TMEM154 protein family Mem_trans PF03547.18 PIK54092.1 - 0.1 11.0 0.0 0.28 9.5 0.0 1.7 2 0 0 2 2 2 0 Membrane transport protein Orf78 PF06024.12 PIK54092.1 - 0.11 12.9 0.1 0.29 11.5 0.1 1.7 1 0 0 1 1 1 0 Orf78 (ac78) Shisa PF13908.6 PIK54092.1 - 0.11 12.7 0.2 0.28 11.4 0.2 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1635 PF07795.11 PIK54092.1 - 0.3 10.9 4.8 0.28 11.0 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Death PF00531.22 PIK54093.1 - 1.2e-06 28.6 0.0 2.2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Death domain AATF-Che1 PF13339.6 PIK54093.1 - 0.19 12.4 0.0 0.36 11.5 0.0 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor TMEM132D_C PF15706.5 PIK54093.1 - 2.1 8.2 3.8 2.2 8.1 0.1 2.6 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term VWD PF00094.25 PIK54094.1 - 5.3e-37 127.5 0.1 9.6e-37 126.7 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK54094.1 - 1.4e-18 67.1 10.5 1.4e-18 67.1 10.5 4.6 4 1 0 4 4 4 1 C8 domain TIL PF01826.17 PIK54094.1 - 1e-14 54.5 62.1 5.4e-09 36.2 17.6 7.0 6 2 1 7 7 7 3 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 PIK54094.1 - 0.0056 17.0 10.3 0.0056 17.0 10.3 6.9 4 4 2 6 6 6 2 von Willebrand factor type C domain LIM PF00412.22 PIK54095.1 - 1.7e-11 44.2 5.9 2.7e-11 43.5 5.9 1.3 1 0 0 1 1 1 1 LIM domain Asp-B-Hydro_N PF05279.11 PIK54095.1 - 9.5 6.2 35.6 11 6.0 35.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4834 PF16118.5 PIK54096.1 - 0.0059 17.6 0.0 0.0063 17.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 PIK54096.1 - 0.02 15.5 0.2 0.024 15.2 0.2 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain B5 PF03484.15 PIK54096.1 - 0.097 13.0 0.1 0.11 12.8 0.1 1.2 1 0 0 1 1 1 0 tRNA synthetase B5 domain ABC_tran PF00005.27 PIK54098.1 - 5.1e-12 46.5 0.0 1.6e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 PIK54098.1 - 4.1e-06 26.4 0.0 4.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 PIK54098.1 - 0.022 15.0 1.4 0.29 11.4 1.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_membrane PF00664.23 PIK54099.1 - 2.8e-50 171.5 6.2 3.7e-50 171.1 6.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK54099.1 - 2e-12 47.8 0.0 7.1e-12 46.0 0.0 1.9 2 0 0 2 2 1 1 ABC transporter AAA_22 PF13401.6 PIK54099.1 - 0.001 19.4 0.0 0.0034 17.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 PIK54099.1 - 0.0055 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 PIK54099.1 - 0.0083 15.9 0.4 0.014 15.1 0.0 1.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 PIK54099.1 - 0.013 16.1 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK54099.1 - 0.014 15.1 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK54099.1 - 0.017 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 PIK54099.1 - 0.022 14.5 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 PIK54099.1 - 0.025 13.9 0.0 0.058 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin APS_kinase PF01583.20 PIK54099.1 - 0.025 14.5 0.0 0.06 13.2 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_33 PF13671.6 PIK54099.1 - 0.025 14.7 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK54099.1 - 0.028 14.2 0.0 0.56 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 PIK54099.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 PIK54099.1 - 0.033 13.9 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase AAA_16 PF13191.6 PIK54099.1 - 0.075 13.4 0.1 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 PIK54099.1 - 0.096 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RVT_1 PF00078.27 PIK54100.1 - 2.7e-17 63.1 0.0 4.9e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK54100.1 - 1.2e-14 54.5 0.1 2.2e-14 53.6 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK54100.1 - 1.1e-07 31.8 0.1 2.1e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK54100.1 - 2.4e-07 30.7 0.4 3.4e-06 27.0 0.0 2.6 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK54100.1 - 0.00019 21.6 0.5 0.03 14.5 0.3 3.1 3 0 0 3 3 3 1 H2C2 zinc finger Fungal_KA1 PF16797.5 PIK54100.1 - 0.05 13.3 0.1 21 4.8 0.0 3.6 3 1 1 4 4 4 0 Fungal kinase associated-1 domain rve PF00665.26 PIK54101.1 - 4.9e-20 71.9 0.0 5.5e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK54101.1 - 0.0041 16.9 0.0 0.011 15.6 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK54101.1 - 0.013 15.8 0.0 0.015 15.6 0.0 1.1 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK54102.1 - 2e-18 66.7 0.1 2.4e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK54103.1 - 2.8e-26 92.0 0.1 3.5e-26 91.7 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK54103.1 - 2.1e-05 24.2 0.3 5.8e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain ATG13 PF10033.9 PIK54103.1 - 0.042 13.5 0.1 0.054 13.2 0.1 1.1 1 0 0 1 1 1 0 Autophagy-related protein 13 muHD PF10291.9 PIK54104.1 - 9.6e-37 126.8 0.0 1.1e-35 123.4 0.0 2.1 1 1 1 2 2 2 1 Muniscin C-terminal mu homology domain Adap_comp_sub PF00928.21 PIK54104.1 - 9.7e-05 21.9 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family DUF4467 PF14729.6 PIK54104.1 - 0.027 14.8 0.2 0.042 14.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) HCO3_cotransp PF00955.21 PIK54105.1 - 4.8e-19 68.6 0.0 7.3e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.22 PIK54105.1 - 0.00049 20.0 0.0 0.00074 19.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PknG_rubred PF16919.5 PIK54105.1 - 0.3 11.2 3.7 0.62 10.2 3.7 1.5 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain HAUS-augmin3 PF14932.6 PIK54106.1 - 6.7e-49 166.8 15.2 6.7e-49 166.8 15.2 2.9 4 0 0 4 4 4 1 HAUS augmin-like complex subunit 3 Apo-CII PF05355.11 PIK54106.1 - 0.031 14.4 1.0 6 7.1 0.0 3.2 3 0 0 3 3 3 0 Apolipoprotein C-II Vps5 PF09325.10 PIK54106.1 - 0.033 13.8 7.9 0.014 15.0 4.8 2.1 2 0 0 2 2 2 0 Vps5 C terminal like DUF1664 PF07889.12 PIK54106.1 - 0.048 13.7 0.5 0.048 13.7 0.5 4.1 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) Tox-REase-9 PF15650.6 PIK54106.1 - 0.15 12.4 0.2 9.5 6.6 0.0 2.9 3 0 0 3 3 3 0 Restriction endonuclease fold toxin 9 DUF2205 PF10224.9 PIK54106.1 - 0.37 10.8 9.9 5.9 7.0 0.7 4.2 3 0 0 3 3 3 0 Short coiled-coil protein HlyD_2 PF12700.7 PIK54106.1 - 0.61 8.8 8.6 0.087 11.5 4.2 1.8 2 0 0 2 2 2 0 HlyD family secretion protein FapA PF03961.13 PIK54106.1 - 0.65 8.5 23.2 0.56 8.7 0.4 3.7 2 2 2 4 4 4 0 Flagellar Assembly Protein A Phasin_2 PF09361.10 PIK54106.1 - 1 9.6 9.9 4.5 7.6 0.8 3.3 3 0 0 3 3 3 0 Phasin protein TMPIT PF07851.13 PIK54106.1 - 2.1 7.5 14.3 0.81 8.9 0.5 3.3 3 0 0 3 3 3 0 TMPIT-like protein 2OG-FeII_Oxy_4 PF13661.6 PIK54108.1 - 1.8e-34 118.2 0.1 1.3e-29 102.7 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Ofd1_CTDD PF10637.9 PIK54108.1 - 4.9e-34 117.8 0.1 5.5e-31 107.8 0.0 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.6 PIK54108.1 - 6.7e-15 55.8 0.0 7.7e-13 49.2 0.0 2.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily SCP2 PF02036.17 PIK54109.1 - 1e-22 80.5 0.1 1.3e-22 80.2 0.1 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 PIK54109.1 - 4.1e-05 23.9 0.0 5.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 PIK54109.1 - 0.0032 17.9 0.0 0.0041 17.5 0.0 1.3 1 1 0 1 1 1 1 Sterol carrier protein domain DUF3211 PF11485.8 PIK54109.1 - 0.0074 16.5 0.1 0.011 15.9 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3211) zinc_ribbon_5 PF13719.6 PIK54109.1 - 0.038 13.7 1.0 0.058 13.2 0.1 1.8 2 0 0 2 2 2 0 zinc-ribbon domain Acyl-CoA_dh_1 PF00441.24 PIK54110.1 - 2.1e-26 93.0 0.1 3.5e-26 92.2 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK54110.1 - 1.6e-22 80.3 0.0 3e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK54110.1 - 3.4e-20 72.1 0.0 5.1e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK54110.1 - 4.5e-05 23.7 0.0 0.00012 22.4 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Y_phosphatase PF00102.27 PIK54111.1 - 6.8e-26 91.3 0.0 7.5e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK54111.1 - 1.2e-05 25.2 0.1 1.7e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain AAA_10 PF12846.7 PIK54111.1 - 0.017 14.1 0.0 0.021 13.7 0.0 1.2 1 1 0 1 1 1 0 AAA-like domain Y_phosphatase3 PF13350.6 PIK54111.1 - 0.037 14.0 0.0 0.071 13.1 0.0 1.3 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 PIK54111.1 - 0.089 12.4 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK54112.1 - 3.2e-75 252.7 8.5 1.6e-74 250.5 4.9 2.4 2 0 0 2 2 2 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK54112.1 - 5.6e-13 49.0 1.5 2.4e-05 24.6 0.0 4.3 4 1 0 4 4 3 2 Fibronectin type III domain Glycophorin_A PF01102.18 PIK54112.1 - 0.00071 19.8 0.2 0.0017 18.6 0.2 1.6 1 0 0 1 1 1 1 Glycophorin A TMEM154 PF15102.6 PIK54112.1 - 0.0029 17.5 1.2 0.0063 16.4 1.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family UPF0560 PF10577.9 PIK54112.1 - 0.006 15.2 1.9 0.031 12.8 0.4 1.9 1 1 1 2 2 2 1 Uncharacterised protein family UPF0560 Stevor PF17410.2 PIK54112.1 - 0.0065 16.1 0.7 0.016 14.8 0.7 1.6 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DSPc PF00782.20 PIK54112.1 - 0.01 15.6 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain LPG_synthase_TM PF03706.13 PIK54112.1 - 0.021 14.4 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region GSHPx PF00255.19 PIK54112.1 - 0.035 13.7 0.1 0.081 12.5 0.1 1.5 1 0 0 1 1 1 0 Glutathione peroxidase Y_phosphatase3 PF13350.6 PIK54112.1 - 0.038 13.9 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CD34_antigen PF06365.12 PIK54112.1 - 0.047 13.3 0.1 0.098 12.2 0.1 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family PTPlike_phytase PF14566.6 PIK54112.1 - 0.047 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Adeno_E3_CR2 PF02439.15 PIK54112.1 - 0.098 12.4 6.2 0.21 11.4 6.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF5305 PF17231.2 PIK54112.1 - 0.1 12.0 0.1 0.22 10.9 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) fn3 PF00041.21 PIK54113.1 - 4e-14 52.7 0.2 0.00039 20.7 0.1 4.0 3 1 0 3 3 3 3 Fibronectin type III domain Brix PF04427.18 PIK54114.1 - 2.1e-28 99.7 1.7 2.9e-28 99.3 1.7 1.2 1 0 0 1 1 1 1 Brix domain CUB PF00431.20 PIK54115.1 - 6.6e-07 29.7 0.0 1.8e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 CUB domain HYR PF02494.16 PIK54115.1 - 1.7e-05 25.1 3.7 0.00037 20.8 0.3 2.3 2 0 0 2 2 2 2 HYR domain PrmA PF06325.13 PIK54116.1 - 4.4e-08 32.9 0.5 8e-08 32.0 0.1 1.5 1 1 1 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.16 PIK54116.1 - 6.5e-06 26.1 0.5 1.4e-05 25.0 0.5 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_25 PF13649.6 PIK54116.1 - 8.2e-06 26.4 0.0 1.7e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 PIK54116.1 - 2.2e-05 23.5 0.0 3.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PRMT5_C PF17286.2 PIK54116.1 - 9.7e-05 22.3 0.1 0.0002 21.3 0.1 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain MTS PF05175.14 PIK54116.1 - 0.00016 21.3 0.0 0.00034 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 PIK54116.1 - 0.00097 18.8 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 PIK54116.1 - 0.0015 18.5 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CARM1 PF11531.8 PIK54116.1 - 0.02 15.1 0.3 0.038 14.2 0.3 1.4 1 0 0 1 1 1 0 Coactivator-associated arginine methyltransferase 1 N terminal Methyltransf_31 PF13847.6 PIK54116.1 - 0.096 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Med8 PF10232.9 PIK54117.1 - 5.3e-37 127.6 2.4 9.7e-37 126.8 2.4 1.4 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 7tm_1 PF00001.21 PIK54117.1 - 5.8e-18 65.2 0.4 6.1e-18 65.1 0.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Baculo_LEF-10 PF07206.11 PIK54117.1 - 0.086 13.0 0.0 0.25 11.5 0.0 1.8 1 0 0 1 1 1 0 Baculovirus late expression factor 10 (LEF-10) ZU5 PF00791.20 PIK54119.1 - 5.1e-15 55.6 0.0 1.1e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK54119.1 - 3.1e-12 46.5 0.2 1e-11 44.8 0.1 1.9 2 0 0 2 2 2 1 Death domain HGTP_anticodon2 PF12745.7 PIK54119.1 - 0.076 12.5 1.4 0.17 11.4 1.4 1.5 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DUF2604 PF10790.9 PIK54119.1 - 0.11 12.8 0.0 1.6 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of Unknown function (DUF2604) BORA_N PF15280.6 PIK54120.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein aurora borealis N-terminus EURL PF06937.11 PIK54121.1 - 1.7e-07 31.0 8.0 0.0016 17.9 1.2 2.3 2 0 0 2 2 2 2 EURL protein FEZ PF07763.13 PIK54121.1 - 0.0054 16.5 1.1 0.0097 15.7 1.1 1.5 1 0 0 1 1 1 1 FEZ-like protein RecR PF02132.15 PIK54121.1 - 0.54 9.9 3.9 0.24 11.0 0.4 2.2 1 1 1 2 2 2 0 RecR protein NDK PF00334.19 PIK54122.1 - 2.2e-34 118.4 0.0 2.1e-22 79.6 0.0 4.7 5 1 0 5 5 5 4 Nucleoside diphosphate kinase HTH_Tnp_Tc5 PF03221.16 PIK54124.1 - 1.5e-10 40.9 0.0 5.1e-10 39.2 0.1 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 PIK54124.1 - 5.8e-07 29.1 0.0 1.7e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 helix-turn-helix, Psq domain DDE_1 PF03184.19 PIK54125.1 - 2.4e-09 37.1 0.4 5.8e-09 35.9 0.1 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease PHD PF00628.29 PIK54125.1 - 8.4e-07 28.8 15.2 1.6e-06 27.9 15.2 1.5 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 PIK54125.1 - 0.0065 16.3 4.4 0.0065 16.3 4.4 2.1 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_L40e PF01020.17 PIK54125.1 - 0.21 11.5 0.1 0.21 11.5 0.1 2.2 2 0 0 2 2 2 0 Ribosomal L40e family Vps39_2 PF10367.9 PIK54125.1 - 0.22 12.0 5.7 0.12 12.8 0.7 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Zf_RING PF16744.5 PIK54125.1 - 0.55 10.4 10.9 1.1 9.4 10.9 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger AAA_11 PF13086.6 PIK54125.1 - 4.8 6.9 11.0 0.2 11.4 5.2 1.6 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.7 PIK54126.1 - 2.9e-16 59.8 0.0 3.9e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54126.1 - 4.5e-14 52.6 0.0 5.1e-07 30.1 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK54126.1 - 7.9e-14 51.4 0.0 2.8e-05 24.3 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK54126.1 - 4e-13 49.3 0.1 0.0001 22.5 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54126.1 - 1.4e-12 46.6 0.0 0.0022 18.4 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat SAM_1 PF00536.30 PIK54127.1 - 6.4e-14 52.2 0.3 3.9e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK54127.1 - 2.5e-10 40.3 0.0 9.5e-10 38.4 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PhoU_div PF01865.16 PIK54127.1 - 0.07 12.4 1.6 0.13 11.5 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF47 GIY-YIG PF01541.24 PIK54128.1 - 0.00026 21.2 0.0 0.00044 20.5 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain Ets PF00178.22 PIK54129.1 - 8.2e-32 109.5 0.9 1.7e-31 108.5 0.9 1.6 1 0 0 1 1 1 1 Ets-domain HSF_DNA-bind PF00447.17 PIK54129.1 - 0.009 16.6 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Astro_capsid_p PF12226.8 PIK54129.1 - 0.52 9.4 10.0 1.2 8.3 10.0 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PPL5 PF18168.1 PIK54129.1 - 3.7 6.7 7.6 6.4 6.0 7.6 1.3 1 0 0 1 1 1 0 Prim-pol family 5 NACHT PF05729.12 PIK54130.1 - 5.3e-08 33.0 0.0 8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 NACHT domain TrmB PF01978.19 PIK54130.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ZU5 PF00791.20 PIK54131.1 - 7.4e-06 26.2 0.1 1.4e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain NACHT PF05729.12 PIK54132.1 - 7.4e-16 58.5 0.0 1.9e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK54132.1 - 0.00013 21.7 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK54132.1 - 0.007 16.8 0.1 0.021 15.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 PIK54132.1 - 0.016 14.5 0.0 0.035 13.4 0.0 1.5 1 0 0 1 1 1 0 KaiC DAP3 PF10236.9 PIK54132.1 - 0.042 13.0 0.0 0.091 11.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 PIK54132.1 - 0.061 13.4 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 PIK54132.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 PIK54132.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 PIK54132.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 PIK54132.1 - 0.18 11.1 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF913 PF06025.12 PIK54134.1 - 3.1 6.7 7.9 55 2.6 7.9 2.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) rve PF00665.26 PIK54137.1 - 6e-22 78.1 0.0 9.6e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK54137.1 - 2.2e-12 46.9 2.4 4.5e-12 45.9 2.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK54137.1 - 0.0029 17.4 0.0 0.006 16.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK54138.1 - 5.7e-32 111.0 0.1 8e-32 110.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK54138.1 - 0.0027 18.3 0.0 0.0082 16.8 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 PIK54138.1 - 0.0075 15.8 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) gag-asp_proteas PF13975.6 PIK54138.1 - 0.0083 16.7 0.0 0.056 14.0 0.0 2.4 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK54138.1 - 0.0095 16.2 0.0 0.049 13.9 0.0 2.1 1 1 0 1 1 1 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 PIK54138.1 - 0.045 13.9 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) rve PF00665.26 PIK54140.1 - 3.7e-21 75.5 0.0 7.5e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK54140.1 - 2.4e-17 62.8 1.4 5.2e-17 61.7 1.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK54140.1 - 0.0019 18.4 0.6 0.0056 16.9 0.6 1.9 1 0 0 1 1 1 1 H2C2 zinc finger 2_5_RNA_ligase2 PF13563.6 PIK54140.1 - 0.0063 16.4 0.0 0.0093 15.9 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK54140.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.7 1 1 0 1 1 1 0 Integrase core domain Trimer_CC PF08954.11 PIK54140.1 - 0.17 11.4 0.2 5 6.8 0.0 2.9 3 0 0 3 3 3 0 Trimerisation motif zf-CCHC PF00098.23 PIK54141.1 - 0.00061 19.8 0.7 0.035 14.2 0.1 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 PIK54141.1 - 0.1 12.6 2.6 2.5 8.1 0.3 2.3 1 1 1 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK54141.1 - 1.5 8.6 8.7 2.4 7.9 0.0 3.0 2 1 1 3 3 3 0 C2H2 zinc-finger XPG_I_2 PF12813.7 PIK54142.1 - 0.14 11.6 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 XPG domain containing Mod_r PF07200.13 PIK54143.1 - 0.016 15.3 2.5 0.025 14.7 2.5 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF4391 PF14335.6 PIK54143.1 - 0.04 13.6 0.6 0.055 13.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) VASP_tetra PF08776.11 PIK54143.1 - 1.4 8.6 4.0 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 VASP tetramerisation domain NACHT PF05729.12 PIK54144.1 - 6.5e-11 42.4 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Sigma54_AID PF00309.20 PIK54144.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) AAA_25 PF13481.6 PIK54144.1 - 0.077 12.6 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Aminotran_4 PF01063.19 PIK54145.1 - 2.4e-05 24.3 0.0 2.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Aminotran_4 PF01063.19 PIK54146.1 - 4.8e-17 62.6 0.0 6.4e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV PADR1 PF08063.12 PIK54146.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 PADR1 (NUC008) domain N2227 PF07942.12 PIK54146.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein zf-RING_UBOX PF13445.6 PIK54147.1 - 2.3e-09 37.1 12.1 5.3e-09 36.0 5.1 3.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54147.1 - 4.1e-09 36.2 10.0 4.1e-09 36.2 10.0 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK54147.1 - 4.5e-08 33.1 10.2 4.5e-08 33.1 10.2 3.2 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK54147.1 - 1.4e-06 28.0 6.8 1.4e-06 28.0 6.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK54147.1 - 5.9e-06 26.0 10.3 5.9e-06 26.0 10.3 3.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54147.1 - 1.9e-05 24.9 9.7 1.9e-05 24.9 9.7 2.5 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK54147.1 - 0.0003 20.7 9.8 0.0003 20.7 9.8 2.9 2 1 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK54147.1 - 0.072 13.1 4.1 0.43 10.7 4.2 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 PIK54147.1 - 0.094 12.5 4.5 0.2 11.5 4.5 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Crust_neurohorm PF01147.17 PIK54147.1 - 0.71 9.7 14.5 0.13 12.1 0.6 3.9 3 1 0 3 3 3 0 Crustacean CHH/MIH/GIH neurohormone family zf-RING_11 PF17123.5 PIK54147.1 - 0.87 9.4 9.1 2.1 8.2 5.3 2.8 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 PIK54147.1 - 2 8.4 18.8 0.44 10.4 10.1 3.4 2 2 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK54148.1 - 1.2e-08 34.8 12.2 4.8e-08 32.9 4.4 3.4 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54148.1 - 1.3e-08 34.6 8.9 1.3e-08 34.6 8.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK54148.1 - 2e-06 27.9 10.5 2e-06 27.9 10.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK54148.1 - 8.1e-06 25.6 8.1 8.1e-06 25.6 8.1 2.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54148.1 - 1.2e-05 25.6 8.1 1.2e-05 25.6 8.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK54148.1 - 1.2e-05 25.1 6.4 1.2e-05 25.1 6.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK54148.1 - 0.00046 20.1 6.7 0.00046 20.1 6.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain DUF3725 PF12523.8 PIK54148.1 - 0.024 14.9 0.3 0.056 13.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) DUF573 PF04504.14 PIK54148.1 - 0.067 13.8 0.2 0.067 13.8 0.2 1.9 2 0 0 2 2 1 0 Protein of unknown function, DUF573 zf-RING_6 PF14835.6 PIK54148.1 - 0.087 12.7 7.2 0.057 13.3 3.6 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Enkurin PF13864.6 PIK54148.1 - 0.092 13.2 4.7 3.4 8.2 1.9 3.1 3 0 0 3 3 3 0 Calmodulin-binding zf-Nse PF11789.8 PIK54148.1 - 0.39 10.6 7.6 0.31 10.9 4.4 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 PIK54148.1 - 0.81 9.8 7.3 0.12 12.4 2.6 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Trm112p PF03966.16 PIK54148.1 - 1.9 9.1 5.4 8.4 7.1 5.4 2.1 1 0 0 1 1 1 0 Trm112p-like protein Prok-RING_4 PF14447.6 PIK54148.1 - 3.1 7.7 13.8 1.3 8.9 8.4 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF1474 PF07342.11 PIK54148.1 - 3.1 8.4 7.1 15 6.2 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1474) zf-RING_11 PF17123.5 PIK54148.1 - 3.2 7.6 8.1 4.7 7.0 4.0 2.8 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 PIK54148.1 - 7.1 7.0 9.3 0.35 11.2 2.8 2.3 2 0 0 2 2 1 0 RING-H2 zinc finger domain MRF_C2 PF13888.6 PIK54149.1 - 3.5e-16 59.3 0.2 7.4e-16 58.3 0.2 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 zf-C3HC4 PF00097.25 PIK54150.1 - 1.1e-08 34.8 11.2 1.1e-08 34.8 11.2 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK54150.1 - 1.7e-08 34.3 6.1 1.7e-08 34.3 6.1 3.9 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK54150.1 - 3.4e-07 30.3 11.2 3.4e-07 30.3 11.2 2.7 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK54150.1 - 9.5e-07 28.6 11.0 9.5e-07 28.6 11.0 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54150.1 - 2.6e-06 27.7 9.5 2.6e-06 27.7 9.5 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK54150.1 - 7.1e-06 25.8 7.2 7.1e-06 25.8 7.2 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK54150.1 - 0.00027 20.8 9.2 0.00027 20.8 9.2 3.3 3 0 0 3 3 3 1 zinc-RING finger domain DASH_Ask1 PF08655.10 PIK54150.1 - 0.00071 19.4 0.6 0.096 12.6 0.1 2.7 2 0 0 2 2 2 1 DASH complex subunit Ask1 DUF2284 PF10050.9 PIK54150.1 - 0.0035 17.1 2.3 0.0076 16.0 0.2 2.5 2 0 0 2 2 2 1 Predicted metal-binding protein (DUF2284) Prok-RING_4 PF14447.6 PIK54150.1 - 0.0044 16.8 8.6 0.0044 16.8 8.6 3.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 GrpE PF01025.19 PIK54150.1 - 0.042 13.5 2.0 0.076 12.7 2.0 1.4 1 0 0 1 1 1 0 GrpE SCAPER_N PF16501.5 PIK54150.1 - 0.11 12.5 2.1 0.96 9.5 0.4 2.7 1 1 1 2 2 2 0 S phase cyclin A-associated protein in the endoplasmic reticulum zf-RING_6 PF14835.6 PIK54150.1 - 0.21 11.5 10.5 0.22 11.4 5.2 2.8 2 1 0 2 2 2 0 zf-RING of BARD1-type protein zinc_ribbon_4 PF13717.6 PIK54150.1 - 2 8.4 7.6 1.6 8.7 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4 PF00097.25 PIK54151.1 - 6.2e-08 32.4 7.8 6.2e-08 32.4 7.8 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK54151.1 - 1.3e-06 28.3 6.2 1.3e-06 28.3 6.2 4.0 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK54151.1 - 2.4e-06 27.6 7.6 2.4e-06 27.6 7.6 2.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK54151.1 - 3.6e-05 23.5 7.8 3.6e-05 23.5 7.8 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54151.1 - 6.8e-05 23.1 6.7 6.8e-05 23.1 6.7 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK54151.1 - 0.00021 21.1 5.3 0.00021 21.1 5.3 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF2284 PF10050.9 PIK54151.1 - 0.0015 18.3 1.2 0.0046 16.7 0.2 2.3 2 0 0 2 2 2 1 Predicted metal-binding protein (DUF2284) zf-RING_5 PF14634.6 PIK54151.1 - 0.0022 17.9 6.0 0.0022 17.9 6.0 3.2 3 0 0 3 3 3 1 zinc-RING finger domain DASH_Ask1 PF08655.10 PIK54151.1 - 0.0035 17.2 0.6 0.43 10.5 0.1 2.7 2 0 0 2 2 2 1 DASH complex subunit Ask1 GrpE PF01025.19 PIK54151.1 - 0.054 13.2 1.5 0.095 12.4 1.5 1.4 1 0 0 1 1 1 0 GrpE zf-ANAPC11 PF12861.7 PIK54151.1 - 0.076 13.1 0.6 0.076 13.1 0.6 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 PIK54151.1 - 1.3 8.9 7.4 1.7 8.6 2.3 2.8 2 1 0 2 2 2 0 zf-RING of BARD1-type protein Anti-TRAP PF15777.5 PIK54151.1 - 2.7 8.0 6.2 0.92 9.5 0.3 2.8 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-NADH-PPase PF09297.11 PIK54151.1 - 4.4 7.0 7.8 18 5.1 0.3 3.6 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Amnionless PF14828.6 PIK54152.1 - 5.3e-43 147.5 1.8 7e-43 147.1 1.8 1.0 1 0 0 1 1 1 1 Amnionless FtsJ PF01728.19 PIK54153.1 - 1.2e-33 116.7 0.0 2.6e-33 115.6 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 PIK54153.1 - 4.9e-13 48.7 3.8 7.4e-13 48.2 3.0 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 PIK54153.1 - 6.7e-05 22.9 1.0 0.00018 21.5 1.0 1.8 1 0 0 1 1 1 1 G-patch domain WW PF00397.26 PIK54153.1 - 0.00023 21.2 0.2 0.0084 16.2 0.0 2.6 2 0 0 2 2 2 1 WW domain FUSC-like PF12805.7 PIK54154.1 - 0.14 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS RT_RNaseH_2 PF17919.1 PIK54155.1 - 6.6e-35 119.1 0.0 1.4e-34 118.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK54155.1 - 3.6e-34 117.2 0.0 9.1e-34 115.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK54155.1 - 3e-23 82.5 0.0 5.4e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK54155.1 - 2.8e-06 27.8 0.0 9e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK54155.1 - 1.4e-05 24.9 7.4 0.0024 17.9 2.1 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 PIK54155.1 - 0.00081 20.0 0.0 0.0024 18.4 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease HTH_Crp_2 PF13545.6 PIK54155.1 - 0.075 13.0 0.1 9.9 6.2 0.0 2.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain zf-CCHC_5 PF14787.6 PIK54155.1 - 0.078 12.7 10.7 0.28 10.9 1.8 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger MarR_2 PF12802.7 PIK54155.1 - 0.13 12.2 0.5 19 5.2 0.0 2.9 3 0 0 3 3 3 0 MarR family MarR PF01047.22 PIK54155.1 - 0.42 10.6 2.8 2.2 8.2 0.1 3.0 3 0 0 3 3 3 0 MarR family zinc-ribbons_6 PF07191.12 PIK54155.1 - 0.56 10.2 5.8 1.3 9.0 5.8 1.5 1 0 0 1 1 1 0 zinc-ribbons PolC_DP2 PF03833.13 PIK54155.1 - 0.95 7.2 11.5 1.7 6.4 11.5 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-CCHC_3 PF13917.6 PIK54155.1 - 4.6 7.3 7.7 1.7 8.7 1.8 2.4 1 1 1 2 2 2 0 Zinc knuckle DUF515 PF04415.12 PIK54155.1 - 5.4 5.3 5.4 1.4 7.2 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF515) MCM PF00493.23 PIK54156.1 - 5.7e-80 267.6 0.0 2.5e-44 151.1 0.0 2.2 2 0 0 2 2 2 2 MCM P-loop domain MCM_lid PF17855.1 PIK54156.1 - 7.4e-27 93.6 1.0 1.4e-26 92.7 1.0 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 PIK54156.1 - 1.6e-25 89.4 1.5 2.8e-25 88.6 1.5 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 PIK54156.1 - 3.9e-07 29.7 0.0 0.0005 19.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 PIK54156.1 - 0.00044 20.1 0.0 0.042 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK54156.1 - 0.00084 19.4 0.0 1.5 8.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK54156.1 - 0.0092 16.4 0.0 0.031 14.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK54156.1 - 0.017 15.4 0.0 0.18 12.1 0.0 2.4 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 PIK54156.1 - 0.053 13.4 0.2 2.5 8.0 0.1 2.8 3 0 0 3 3 3 0 NTPase FtsK_SpoIIIE PF01580.18 PIK54156.1 - 0.066 12.6 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family TMEM95 PF15203.6 PIK54157.1 - 0.071 12.8 1.0 0.15 11.7 0.1 1.9 2 0 0 2 2 2 0 TMEM95 family DUF1364 PF07102.12 PIK54158.1 - 0.026 14.3 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) Rap_GAP PF02145.15 PIK54160.1 - 2.3e-05 24.1 0.0 0.26 10.8 0.0 3.0 2 1 0 2 2 2 2 Rap/ran-GAP Transglut_core PF01841.19 PIK54161.1 - 0.028 14.9 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily QVR PF17064.5 PIK54163.1 - 0.024 14.9 0.1 0.024 14.9 0.1 2.0 2 1 0 2 2 2 0 Sleepless protein Metallothio_PEC PF02068.16 PIK54163.1 - 1.1 9.6 11.1 0.18 12.2 3.3 2.8 2 1 1 3 3 3 0 Plant PEC family metallothionein Yip1 PF04893.17 PIK54164.1 - 3.4e-11 43.2 21.2 7.4e-11 42.1 20.9 1.8 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 PIK54164.1 - 0.0092 15.8 11.6 0.015 15.1 11.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) AreA_N PF07573.11 PIK54164.1 - 0.11 13.1 2.0 0.2 12.3 2.0 1.4 1 0 0 1 1 1 0 Nitrogen regulatory protein AreA N terminus DUF1189 PF06691.11 PIK54164.1 - 3.2 7.2 12.1 0.4 10.2 7.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) PH PF00169.29 PIK54165.1 - 0.022 15.3 0.2 0.096 13.2 0.0 2.2 2 0 0 2 2 2 0 PH domain RVT_1 PF00078.27 PIK54168.1 - 1.2e-18 67.5 0.0 3.2e-18 66.1 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK54168.1 - 3.7e-05 23.9 0.1 0.00028 21.1 0.1 2.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK54168.1 - 0.029 14.4 0.1 0.18 11.9 0.1 2.3 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DUF1664 PF07889.12 PIK54168.1 - 0.078 13.0 0.2 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Phage_int_SAM_4 PF13495.6 PIK54169.1 - 0.013 16.0 0.0 0.03 14.8 0.0 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK54169.1 - 0.18 12.2 0.2 0.18 12.2 0.2 2.0 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK54171.1 - 0.01 16.3 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK54171.1 - 0.015 15.6 1.3 0.026 14.8 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain GHMP_kinases_N PF00288.26 PIK54172.1 - 3.1e-15 56.1 1.1 8.9e-15 54.7 1.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 PIK54172.1 - 2.6e-06 27.7 0.5 7.2e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal PAS_8 PF13188.7 PIK54172.1 - 0.1 12.6 0.0 0.99 9.5 0.0 2.4 2 0 0 2 2 2 0 PAS domain ING PF12998.7 PIK54172.1 - 0.17 12.5 0.1 0.32 11.6 0.1 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding zf-ZPR1 PF03367.13 PIK54173.1 - 7.8e-115 380.1 1.7 1.7e-58 197.0 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 PIK54173.1 - 0.00025 21.0 3.7 0.18 11.9 0.8 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 PIK54173.1 - 0.87 9.8 6.6 12 6.1 1.1 3.5 3 1 0 3 3 3 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 PIK54173.1 - 1.1 9.2 5.1 1.7 8.6 0.0 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-ISL3 PF14690.6 PIK54173.1 - 3 8.6 6.2 41 4.9 0.1 3.3 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 RRN3 PF05327.11 PIK54174.1 - 1.3 7.5 6.0 1.6 7.2 6.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ank_2 PF12796.7 PIK54175.1 - 4.9e-20 71.9 0.8 2.6e-10 40.8 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54175.1 - 1.3e-17 63.9 0.3 7.7e-05 23.2 0.0 5.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK54175.1 - 5.9e-16 58.3 2.3 7.5e-07 29.3 0.0 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54175.1 - 5.3e-12 44.8 1.2 0.36 11.5 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 PIK54175.1 - 1.2e-11 44.5 2.8 0.0092 16.4 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Glyco_tranf_2_5 PF13712.6 PIK54175.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family LIG3_BRCT PF16759.5 PIK54175.1 - 0.16 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Ten1_2 PF15490.6 PIK54176.1 - 2.1e-21 75.8 0.0 2.9e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit ABC_tran PF00005.27 PIK54177.1 - 0.0041 17.6 0.0 0.0099 16.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 PIK54177.1 - 0.0096 16.5 0.0 0.018 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 PIK54177.1 - 0.036 14.1 0.1 0.095 12.8 0.1 1.7 1 0 0 1 1 1 0 Dynamin family ESM4 PF15952.5 PIK54177.1 - 0.062 13.7 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Enhancer of split M4 family MeaB PF03308.16 PIK54177.1 - 0.084 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 PIK54177.1 - 0.087 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 PIK54177.1 - 0.17 11.6 0.1 0.82 9.5 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF87 PF01935.17 PIK54177.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain DUF608 PF04685.13 PIK54179.1 - 0.2 10.8 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region JAB PF01398.21 PIK54180.1 - 3.3e-24 85.1 0.0 5e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 PIK54180.1 - 5e-24 84.9 1.1 8e-24 84.2 1.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function HAUS5 PF14817.6 PIK54181.1 - 1.6e-14 53.7 1.6 1.7e-14 53.6 1.6 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 HAUS5 PF14817.6 PIK54182.1 - 1e-12 47.7 0.2 1.2e-12 47.5 0.2 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Cobalamin_bind PF01122.19 PIK54183.1 - 3.4e-11 42.6 0.0 4.8e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF898 PF05987.13 PIK54183.1 - 0.0048 16.0 1.6 0.0053 15.8 1.6 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) RSN1_TM PF13967.6 PIK54183.1 - 0.023 14.5 0.1 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport Nop14 PF04147.12 PIK54183.1 - 0.052 11.8 32.6 0.079 11.2 32.6 1.3 1 0 0 1 1 1 0 Nop14-like family Claudin_2 PF13903.6 PIK54183.1 - 0.071 12.9 1.6 0.13 12.0 1.6 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DHHC PF01529.20 PIK54183.1 - 0.16 12.1 7.6 5.1 7.2 7.6 2.2 1 1 0 1 1 1 0 DHHC palmitoyltransferase DUF2615 PF11027.8 PIK54183.1 - 0.18 11.9 15.8 9.6 6.4 15.8 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) Nitroreductase PF00881.24 PIK54183.1 - 0.35 10.9 3.1 0.58 10.2 3.1 1.4 1 0 0 1 1 1 0 Nitroreductase family SpoIIIAH PF12685.7 PIK54183.1 - 0.66 9.8 8.9 1.1 9.0 8.9 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein CobT PF06213.12 PIK54183.1 - 6 6.2 31.9 9.3 5.5 27.5 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Dynactin_p62 PF05502.13 PIK54184.1 - 2.5e-24 85.9 6.2 9.8e-15 54.3 0.5 2.1 2 0 0 2 2 2 2 Dynactin p62 family zf-3CxxC PF13695.6 PIK54184.1 - 0.012 16.0 3.7 5.2 7.6 1.7 2.7 2 1 0 2 2 2 0 Zinc-binding domain Big_2 PF02368.18 PIK54185.1 - 1.2e-14 53.9 13.6 1e-06 28.5 0.0 8.0 9 0 0 9 9 9 4 Bacterial Ig-like domain (group 2) T2SS-T3SS_pil_N PF13629.6 PIK54185.1 - 0.0061 16.3 0.0 0.14 11.9 0.0 3.4 3 0 0 3 3 3 1 Pilus formation protein N terminal region CBM-like PF14683.6 PIK54185.1 - 0.11 12.4 0.0 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain III TPR_1 PF00515.28 PIK54186.1 - 2.1e-21 74.8 0.8 2.8e-10 39.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54186.1 - 7.7e-16 56.9 1.1 1.5e-08 34.1 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK54186.1 - 1.5e-14 53.4 1.7 9.3e-09 34.8 0.7 3.4 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 PIK54186.1 - 4e-10 39.1 0.0 3.5e-05 23.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK54186.1 - 1.3e-09 38.0 0.5 8e-05 23.1 0.1 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK54186.1 - 2.5e-09 37.3 0.1 7.6e-05 22.9 0.0 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK54186.1 - 2.6e-09 37.1 1.0 2.7e-06 27.4 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK54186.1 - 3.6e-08 33.9 0.3 2.3e-07 31.3 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK54186.1 - 8.2e-07 29.0 0.1 0.00048 20.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK54186.1 - 1.7e-06 28.4 0.7 0.0029 18.1 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK54186.1 - 9e-06 25.4 0.7 0.039 13.8 0.0 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK54186.1 - 1.4e-05 24.8 0.6 0.43 10.7 0.0 3.6 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK54186.1 - 0.00018 22.0 0.1 0.027 15.1 0.0 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK54186.1 - 0.0011 18.4 5.0 0.47 9.9 0.0 3.6 4 0 0 4 4 4 2 SHNi-TPR TPR_4 PF07721.14 PIK54186.1 - 0.031 14.9 0.3 0.95 10.3 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.9 PIK54186.1 - 0.045 13.4 0.4 0.41 10.3 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 PIK54186.1 - 0.058 12.8 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region ANAPC5 PF12862.7 PIK54186.1 - 0.084 13.0 0.1 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Fis1_TPR_C PF14853.6 PIK54186.1 - 0.12 12.4 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat LLC1 PF14945.6 PIK54187.1 - 1e-05 26.1 0.8 0.0056 17.3 0.2 2.2 1 1 1 2 2 2 2 Normal lung function maintenance, Low in Lung Cancer 1 protein DUF4131 PF13567.6 PIK54188.1 - 0.0025 17.5 0.1 0.0035 17.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) PET PF06297.14 PIK54189.1 - 3.6e-25 88.1 1.8 4.5e-25 87.8 0.2 2.0 2 0 0 2 2 2 1 PET Domain LIM PF00412.22 PIK54189.1 - 8.2e-11 42.0 11.8 2.6e-10 40.3 4.2 2.6 2 0 0 2 2 2 2 LIM domain Vasculin PF15337.6 PIK54189.1 - 0.58 11.0 0.1 0.58 11.0 0.1 3.1 3 0 0 3 3 3 0 Vascular protein family Vasculin-like 1 CRT-like PF08627.10 PIK54190.1 - 2.3e-21 76.1 13.0 1.7e-20 73.3 13.0 1.9 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like GTP_EFTU PF00009.27 PIK54191.1 - 4.1e-25 88.5 0.5 1.4e-24 86.7 0.5 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK54191.1 - 2.1e-07 31.0 0.1 5.9e-07 29.6 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 PIK54191.1 - 5.7e-06 26.6 0.1 1.2e-05 25.6 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.10 PIK54191.1 - 0.00016 21.2 1.8 0.0018 17.7 1.8 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK54191.1 - 0.00026 20.4 1.7 0.00069 19.0 1.7 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MlaE PF02405.16 PIK54191.1 - 0.011 15.5 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Permease MlaE Septin PF00735.18 PIK54191.1 - 0.026 13.8 0.1 0.049 12.9 0.1 1.5 1 0 0 1 1 1 0 Septin MMR_HSR1_Xtn PF16897.5 PIK54191.1 - 0.034 14.1 0.5 0.088 12.8 0.5 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain PduV-EutP PF10662.9 PIK54191.1 - 0.038 13.7 1.0 3 7.6 0.0 2.8 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FliS_cochap PF16522.5 PIK54191.1 - 0.05 13.6 0.4 0.1 12.5 0.4 1.6 1 0 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 Dynamin_N PF00350.23 PIK54191.1 - 0.088 12.9 0.3 19 5.3 0.1 2.7 1 1 1 2 2 2 0 Dynamin family LRR19-TM PF15176.6 PIK54192.1 - 2.2 8.3 5.6 4.6 7.3 5.6 1.5 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Tugs PF17840.1 PIK54193.1 - 9.7e-13 48.1 0.2 1.6e-12 47.4 0.2 1.3 1 0 0 1 1 1 1 Tethering Ubl4a to BAGS domain ubiquitin PF00240.23 PIK54193.1 - 8e-07 28.7 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family CCDC142 PF14923.6 PIK54193.1 - 0.075 11.8 0.0 0.082 11.6 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil protein 142 Rad60-SLD PF11976.8 PIK54193.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PDZ PF00595.24 PIK54194.1 - 5e-16 58.8 0.0 6.5e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK54194.1 - 4.8e-11 42.3 0.0 6.7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK54194.1 - 7.4e-05 23.0 0.0 0.00017 21.8 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 PIK54195.1 - 8e-42 141.5 9.7 6.2e-16 58.5 0.2 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK54195.1 - 3.6e-21 74.8 5.7 4.2e-09 36.1 0.1 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK54195.1 - 1.3e-18 67.1 2.1 3.6e-06 27.2 0.1 3.3 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 PIK54195.1 - 0.0006 19.7 0.8 0.68 9.9 0.0 3.2 3 0 0 3 3 3 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 PIK54195.1 - 0.21 12.0 0.1 33 4.9 0.0 3.1 3 0 0 3 3 3 0 PDZ domain PDZ PF00595.24 PIK54196.1 - 1.2e-10 41.6 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK54196.1 - 1.3e-09 37.8 0.0 2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK54196.1 - 1.1e-07 32.1 0.0 1.8e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain WW PF00397.26 PIK54197.1 - 3e-14 52.8 5.6 1.1e-06 28.6 0.4 2.5 2 0 0 2 2 2 2 WW domain Arabino_trans_C PF14896.6 PIK54197.1 - 0.0051 15.9 0.7 0.0064 15.6 0.7 1.1 1 0 0 1 1 1 1 EmbC C-terminal domain CDC45 PF02724.14 PIK54197.1 - 0.36 9.1 11.3 0.35 9.1 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 PIK54197.1 - 0.49 9.8 16.1 0.59 9.5 16.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 PIK54197.1 - 1 7.5 15.9 1.1 7.4 15.9 1.0 1 0 0 1 1 1 0 Nop14-like family Sox_N PF12444.8 PIK54197.1 - 4.8 8.4 13.6 0.16 13.1 2.4 2.7 3 0 0 3 3 3 0 Sox developmental protein N terminal Presenilin PF01080.17 PIK54197.1 - 5.1 5.8 8.7 6.2 5.5 8.7 1.3 1 0 0 1 1 1 0 Presenilin FlaG PF03646.15 PIK54197.1 - 5.4 7.2 12.9 1.9 8.7 0.0 2.8 3 0 0 3 3 3 0 FlaG protein DUF3915 PF13054.6 PIK54197.1 - 5.7 7.0 5.8 10 6.2 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Tim17 PF02466.19 PIK54198.1 - 2.7e-15 56.7 8.6 4.2e-15 56.1 8.6 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Rick_17kDa_Anti PF05433.15 PIK54198.1 - 1.8 8.5 10.8 2.6 8.0 4.9 2.6 2 0 0 2 2 2 0 Glycine zipper 2TM domain Cofilin_ADF PF00241.20 PIK54199.1 - 1.2e-37 128.4 0.1 9.3e-21 73.9 0.1 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein ADH_N_2 PF16884.5 PIK54201.1 - 5.7e-32 109.8 0.0 1.4e-31 108.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 PIK54201.1 - 3.8e-21 75.4 0.0 5.6e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK54201.1 - 1.6e-07 32.5 0.0 2.9e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Tetraspanin PF00335.20 PIK54202.1 - 3.4e-29 102.2 15.4 3.4e-29 102.2 15.4 1.3 2 0 0 2 2 2 1 Tetraspanin family MgtE PF01769.16 PIK54202.1 - 0.018 15.4 0.4 0.018 15.4 0.4 3.0 2 1 0 2 2 2 0 Divalent cation transporter MSP1a PF11670.8 PIK54202.1 - 0.99 8.6 7.9 0.39 10.0 2.4 2.1 2 0 0 2 2 2 0 Major surface protein 1a (MSP1a) Tetraspanin PF00335.20 PIK54203.1 - 1.3e-26 93.8 1.9 1.6e-26 93.4 1.9 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2254 PF10011.9 PIK54203.1 - 3.4 6.4 9.5 5.3 5.8 9.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Bcl-2 PF00452.19 PIK54204.1 - 9.9e-20 71.1 0.1 2e-19 70.1 0.1 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BUD22 PF09073.10 PIK54205.1 - 0.032 13.6 24.0 0.034 13.5 24.0 1.0 1 0 0 1 1 1 0 BUD22 Neur_chan_memb PF02932.16 PIK54205.1 - 0.05 13.7 1.7 0.061 13.4 1.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sulfotransfer_1 PF00685.27 PIK54207.1 - 3.8e-11 43.0 1.7 3e-10 40.0 1.7 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK54207.1 - 8.5e-10 39.4 0.0 1.8e-06 28.5 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family YMF19 PF02326.15 PIK54207.1 - 0.033 15.0 0.3 0.31 11.8 0.1 2.3 2 0 0 2 2 2 0 Plant ATP synthase F0 BRAP2 PF07576.12 PIK54207.1 - 0.12 12.6 0.5 0.35 11.1 0.2 1.9 2 0 0 2 2 2 0 BRCA1-associated protein 2 Sulfotransfer_3 PF13469.6 PIK54208.1 - 9.6e-11 42.5 0.3 2.7e-07 31.2 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK54208.1 - 3.5e-09 36.5 0.3 2.2e-07 30.6 0.3 2.2 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK54209.1 - 3.5e-07 30.0 0.0 3.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK54209.1 - 0.00024 21.5 0.1 0.00034 21.0 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Glycogen_syn PF05693.13 PIK54210.1 - 0 1110.9 0.0 0 1110.6 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.11 PIK54210.1 - 7e-06 25.9 0.0 1.7e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_transf_4 PF13439.6 PIK54210.1 - 2.8e-05 24.2 0.0 6.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 PIK54210.1 - 3.6e-05 23.4 0.0 0.00089 18.8 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 PIK54210.1 - 9.3e-05 22.9 0.0 0.0056 17.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 PIK54210.1 - 0.00022 21.7 0.0 0.00057 20.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain EamA PF00892.20 PIK54211.1 - 1.2e-09 38.5 32.0 1.4e-06 28.6 12.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family NB PF04159.13 PIK54211.1 - 1.3 9.1 0.0 1.3 9.1 0.0 3.1 3 1 0 4 4 4 0 NB glycoprotein ERGIC_N PF13850.6 PIK54212.1 - 1.8e-19 69.8 0.0 2.2e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) COPIIcoated_ERV PF07970.12 PIK54213.1 - 3.4e-44 151.3 0.1 4.6e-44 150.9 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter AAA_25 PF13481.6 PIK54214.1 - 1.8e-22 79.9 0.0 2.8e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 PIK54214.1 - 5.1e-13 48.9 0.0 9e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 PIK54214.1 - 1.9e-06 28.2 0.0 3.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK54214.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 KaiC PRK PF00485.18 PIK54214.1 - 0.0023 17.7 0.1 0.0047 16.7 0.1 1.5 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 PIK54214.1 - 0.0024 17.6 0.0 0.0069 16.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 PIK54214.1 - 0.0027 18.1 0.0 0.0052 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 PIK54214.1 - 0.0037 16.4 0.1 0.0061 15.7 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 PIK54214.1 - 0.0038 16.8 0.1 0.1 12.1 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 PIK54214.1 - 0.02 15.4 0.0 0.066 13.7 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 PIK54214.1 - 0.022 15.3 2.0 0.022 15.3 2.0 2.6 3 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 PIK54214.1 - 0.064 13.4 0.0 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 PIK54214.1 - 0.14 11.9 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 PIK54214.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 PIK54214.1 - 0.17 11.6 0.1 0.32 10.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain N_BRCA1_IG PF16158.5 PIK54215.1 - 1.9e-31 108.8 0.2 3.5e-31 108.0 0.2 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PCI PF01399.27 PIK54216.1 - 1.1e-11 45.1 4.0 1.1e-11 45.1 4.0 1.8 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 PIK54216.1 - 3.2e-08 33.1 1.6 7e-08 32.0 1.6 1.7 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix Stn1_C PF12659.7 PIK54216.1 - 0.0078 16.2 3.0 0.011 15.6 1.1 2.1 2 0 0 2 2 2 1 Telomere capping C-terminal wHTH DUF3781 PF12636.7 PIK54216.1 - 0.021 14.7 0.5 0.054 13.4 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3781) Macro PF01661.21 PIK54216.1 - 0.11 12.5 0.0 0.92 9.6 0.0 2.3 2 0 0 2 2 2 0 Macro domain DUF5106 PF17127.4 PIK54216.1 - 0.11 12.7 0.5 0.7 10.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) Xpo1 PF08389.12 PIK54216.1 - 2.7 8.0 9.4 0.43 10.6 2.4 2.9 2 2 1 3 3 3 0 Exportin 1-like protein CREPT PF16566.5 PIK54217.1 - 0.0049 17.0 8.8 0.0049 17.0 8.8 5.4 1 1 4 5 5 5 2 Cell-cycle alteration and expression-elevated protein in tumour DUF3440 PF11922.8 PIK54217.1 - 0.46 10.2 2.8 0.26 11.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3440) DUF4988 PF16378.5 PIK54217.1 - 4.2 7.0 11.5 8.5 6.0 1.0 4.0 3 1 0 3 3 3 0 Domain of unknown function NPV_P10 PF05531.12 PIK54217.1 - 6.6 7.3 23.8 6.1 7.4 0.9 6.2 5 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 PIK54217.1 - 9.8 6.3 73.9 1.3 9.2 18.4 4.6 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) SAM_1 PF00536.30 PIK54218.1 - 1.1e-23 83.4 0.1 1.9e-11 44.2 0.1 3.1 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK54218.1 - 1.3e-22 79.7 2.1 1.7e-08 34.4 0.0 3.2 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Fam20C PF06702.12 PIK54219.1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Golgi casein kinase, C-terminal, Fam20 Glyco_transf_21 PF13506.6 PIK54219.1 - 0.075 12.5 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 HTH_3 PF01381.22 PIK54220.1 - 4e-05 23.6 0.5 4e-05 23.6 0.5 2.2 3 0 0 3 3 3 1 Helix-turn-helix HTH_19 PF12844.7 PIK54220.1 - 0.017 15.1 5.3 0.023 14.7 2.8 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_31 PF13560.6 PIK54220.1 - 0.032 14.6 2.1 0.13 12.6 2.0 2.0 1 1 0 1 1 1 0 Helix-turn-helix domain IQ PF00612.27 PIK54220.1 - 0.079 12.8 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF5584 PF17822.1 PIK54220.1 - 0.18 11.3 1.1 0.29 10.6 1.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5584) LRR_4 PF12799.7 PIK54221.1 - 8.9e-14 51.4 39.7 8.3e-05 22.9 4.3 5.8 4 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK54221.1 - 1.1e-12 47.5 30.2 9.5e-08 31.7 2.9 5.0 2 1 3 5 5 5 4 Leucine rich repeat IQ PF00612.27 PIK54221.1 - 6.4e-12 44.2 5.1 8.9e-06 25.1 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif LRR_9 PF14580.6 PIK54221.1 - 0.00059 19.4 0.5 0.00059 19.4 0.5 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 PIK54221.1 - 0.08 13.0 24.9 1.3 9.3 0.3 7.0 6 1 1 7 7 7 0 Leucine Rich repeat DUF4020 PF13212.6 PIK54222.1 - 0.15 11.9 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4020) Na_H_Exchanger PF00999.21 PIK54223.1 - 2.5e-54 184.5 40.2 3.6e-54 184.0 40.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Alpha-amylase PF00128.24 PIK54223.1 - 0.012 15.2 2.6 0.017 14.7 2.6 1.2 1 0 0 1 1 1 0 Alpha amylase, catalytic domain PHM7_cyt PF14703.6 PIK54223.1 - 3.3 7.9 6.0 7.1 6.8 6.0 1.6 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Abhydrolase_3 PF07859.13 PIK54225.1 - 6.3e-35 121.0 0.0 7.6e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 PIK54225.1 - 1.1e-05 24.5 0.0 1.4e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 PIK54225.1 - 3.4e-05 22.9 0.1 0.00038 19.5 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK54225.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 PIK54227.1 - 1.1e-51 175.7 0.1 2.7e-35 122.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK54227.1 - 2.1e-05 23.6 0.2 0.00012 21.2 0.2 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 PIK54227.1 - 7.7e-05 21.7 0.0 0.00011 21.2 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 PIK54227.1 - 0.00069 19.1 0.0 0.069 12.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 PIK54229.1 - 4.3e-51 173.8 0.1 5.3e-35 121.2 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK54229.1 - 0.00022 20.2 0.2 0.0014 17.6 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 PIK54229.1 - 0.00047 19.7 0.1 0.06 12.8 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 PIK54229.1 - 0.00089 18.2 0.1 0.0013 17.7 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase RCC1 PF00415.18 PIK54230.1 - 4.5e-55 184.1 21.6 2.7e-13 50.3 0.4 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK54230.1 - 5.4e-34 115.3 27.4 1.7e-11 43.6 2.2 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 PIK54230.1 - 8.1e-14 51.8 5.0 2e-08 34.4 0.3 3.2 1 1 2 3 3 3 2 BTB/POZ domain BACK PF07707.15 PIK54230.1 - 0.00019 21.5 2.8 0.0068 16.5 0.6 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF4213 PF13938.6 PIK54230.1 - 0.005 17.0 1.5 1.5 9.1 0.1 2.6 2 0 0 2 2 2 2 Putative heavy-metal chelation GAD-like PF08887.11 PIK54230.1 - 0.097 12.5 0.4 3.7 7.4 0.1 3.0 3 0 0 3 3 3 0 GAD-like domain PALP PF00291.25 PIK54231.1 - 4.7e-26 91.9 0.0 5.5e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cwf_Cwc_15 PF04889.12 PIK54232.1 - 1.3e-72 244.6 16.5 1.8e-72 244.0 16.5 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Ribosomal_L34e PF01199.18 PIK54233.1 - 0.032 14.5 2.7 0.047 14.0 2.7 1.3 1 0 0 1 1 1 0 Ribosomal protein L34e DUF4239 PF14023.6 PIK54234.1 - 0.011 15.5 1.4 0.014 15.1 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF3510 PF12022.8 PIK54234.1 - 0.012 15.9 1.3 0.012 15.9 1.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) PKcGMP_CC PF16808.5 PIK54234.1 - 0.018 14.9 0.6 0.033 14.0 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Cro PF09048.10 PIK54234.1 - 0.02 14.9 0.6 0.02 14.9 0.6 2.8 3 0 0 3 3 3 0 Cro Ecl1 PF12855.7 PIK54234.1 - 0.02 16.1 0.7 0.024 15.8 0.7 1.1 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins AAA_lid_6 PF17866.1 PIK54234.1 - 0.072 13.3 0.9 5.7 7.2 0.0 3.1 3 1 0 3 3 3 0 AAA lid domain DUF3813 PF12758.7 PIK54234.1 - 8.9 6.7 9.8 1.8 9.0 3.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3813) DUF1736 PF08409.11 PIK54236.1 - 0.048 13.7 32.7 1.2e+02 2.8 0.0 11.3 1 1 12 13 13 13 0 Domain of unknown function (DUF1736) FAM150 PF15129.6 PIK54236.1 - 0.084 13.0 18.8 43 4.3 0.3 6.2 1 1 6 7 7 7 0 FAM150 family DDE_Tnp_1_7 PF13843.6 PIK54237.1 - 1.7e-09 37.5 0.1 0.00017 21.0 0.0 2.1 1 1 1 2 2 2 2 Transposase IS4 BNR_assoc_N PF14873.6 PIK54237.1 - 0.034 13.9 0.1 0.085 12.5 0.0 1.6 2 0 0 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase FAP PF07174.11 PIK54237.1 - 0.39 10.1 10.1 0.52 9.7 10.1 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) zf-C2H2_10 PF16588.5 PIK54238.1 - 0.012 15.4 0.8 0.012 15.4 0.8 2.4 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK54238.1 - 0.033 14.2 14.9 0.12 12.3 1.1 3.8 3 1 1 4 4 4 0 Zinc knuckle zf-CCHC PF00098.23 PIK54238.1 - 0.49 10.6 18.3 2.3 8.5 0.2 4.3 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK54238.1 - 2 8.2 10.9 2.6 7.9 0.3 3.1 2 1 1 3 3 3 0 Zinc knuckle DUF4371 PF14291.6 PIK54239.1 - 3.4e-33 115.3 0.4 5.6e-33 114.6 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK54239.1 - 0.039 13.8 0.9 0.22 11.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) DUF3069 PF11269.8 PIK54239.1 - 0.04 14.2 0.0 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3069) RVT_1 PF00078.27 PIK54242.1 - 9.4e-17 61.3 0.0 1.3e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK54243.1 - 4.6e-08 32.8 15.1 0.00035 20.5 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK54243.1 - 0.00014 21.6 7.7 0.052 13.4 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK54243.1 - 0.0062 16.5 16.0 0.099 12.6 0.9 3.6 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK54243.1 - 0.0063 16.2 11.1 2.7 7.8 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK54243.1 - 0.012 15.4 0.2 0.012 15.4 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK54243.1 - 0.012 15.3 0.8 0.012 15.3 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger Helitron_like_N PF14214.6 PIK54244.1 - 8.2e-28 97.9 0.1 8.2e-28 97.9 0.1 1.5 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus DUF3399 PF11879.8 PIK54244.1 - 0.07 13.5 0.2 0.33 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) zf-CCHC_6 PF15288.6 PIK54245.1 - 0.0026 17.6 1.6 0.027 14.3 1.6 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 PIK54245.1 - 0.077 13.1 0.4 0.077 13.1 0.4 1.9 2 0 0 2 2 2 0 Zinc knuckle BEN PF10523.9 PIK54247.1 - 5.8e-08 32.9 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 BEN domain Cas_DxTHG PF09455.10 PIK54248.1 - 0.063 12.8 0.0 0.077 12.6 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family RVT_1 PF00078.27 PIK54248.1 - 0.071 12.6 0.1 0.38 10.2 0.0 2.2 3 0 0 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK54249.1 - 2.9e-07 30.2 15.8 0.00052 20.0 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK54249.1 - 0.00041 20.1 8.0 0.08 12.8 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK54249.1 - 0.018 14.9 0.2 0.018 14.9 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK54249.1 - 0.018 14.8 0.8 0.018 14.8 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK54249.1 - 0.02 14.6 11.3 4 7.2 0.4 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK54249.1 - 0.042 13.8 18.1 0.21 11.6 1.3 4.2 3 1 2 5 5 5 0 Zinc knuckle zf-CCHC PF00098.23 PIK54250.1 - 0.28 11.3 3.2 6.9 6.9 0.1 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-ribbon_3 PF13248.6 PIK54250.1 - 0.81 9.2 3.4 8.6 5.9 0.4 2.8 2 0 0 2 2 2 0 zinc-ribbon domain DUF2195 PF09961.9 PIK54251.1 - 0.019 14.9 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2195) Pkinase PF00069.25 PIK54253.1 - 4.9e-12 45.8 0.0 6.3e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54253.1 - 8e-11 41.7 0.0 9.8e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 PIK54254.1 - 0.036 14.6 0.0 0.15 12.6 0.0 2.0 1 0 0 1 1 1 0 PH domain MARVEL PF01284.23 PIK54255.1 - 5.2 7.1 24.9 36 4.4 24.9 2.0 1 1 0 1 1 1 0 Membrane-associating domain Forkhead PF00250.18 PIK54256.1 - 2.4e-37 127.0 0.0 3.9e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain CEP76-C2 PF15627.6 PIK54257.1 - 1.9e-57 193.3 0.0 1.1e-56 190.8 0.0 2.0 2 0 0 2 2 2 1 CEP76 C2 domain Transglut_core3 PF13471.6 PIK54257.1 - 0.021 14.8 0.1 0.054 13.4 0.1 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Transglut_core PF01841.19 PIK54257.1 - 0.15 12.6 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF1704 PF08014.11 PIK54258.1 - 1.9e-12 46.9 0.0 8.1e-12 44.8 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1704) Microvir_J PF04726.13 PIK54258.1 - 0.025 14.5 0.7 0.082 12.9 0.7 1.9 1 0 0 1 1 1 0 Microvirus J protein Gpi16 PF04113.14 PIK54259.1 - 2.8e-146 488.3 0.1 1.3e-144 482.8 0.1 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component BRF1 PF07741.13 PIK54259.1 - 1.2 9.6 6.9 2 8.8 6.9 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RT_RNaseH PF17917.1 PIK54260.1 - 4.1e-35 120.2 0.0 5.3e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK54260.1 - 5.9e-33 112.9 0.0 8e-33 112.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PfkB PF00294.24 PIK54262.1 - 3.1e-66 223.7 0.5 3.6e-66 223.5 0.5 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 PIK54262.1 - 1.7e-08 34.2 0.0 3e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PSII_BNR PF14870.6 PIK54262.1 - 0.2 10.9 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 PfkB PF00294.24 PIK54263.1 - 1.9e-48 165.3 2.8 2.1e-45 155.4 0.4 2.5 2 1 0 2 2 2 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 PIK54263.1 - 1.3e-07 31.3 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF3014 PF11219.8 PIK54266.1 - 0.14 12.5 0.0 4.5 7.5 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3014) WW PF00397.26 PIK54266.1 - 0.31 11.2 10.6 0.045 13.8 4.4 2.4 2 0 0 2 2 2 0 WW domain AhpC-TSA_2 PF13911.6 PIK54267.1 - 5.7e-08 32.9 0.1 1.1e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 PIK54267.1 - 0.041 13.8 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family AhpC-TSA_2 PF13911.6 PIK54269.1 - 1.1e-08 35.2 0.1 1.6e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Gloverin PF10793.9 PIK54269.1 - 0.074 12.9 0.1 1.9 8.4 0.0 2.0 1 1 1 2 2 2 0 Gloverin-like protein AhpC-TSA PF00578.21 PIK54269.1 - 0.078 12.9 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Peptidase_C97 PF05903.14 PIK54269.1 - 0.17 11.7 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain Il2rg PF15874.5 PIK54270.1 - 3.6e-28 97.7 0.0 4.6e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain DUF4023 PF13215.6 PIK54270.1 - 0.17 11.9 3.1 1.1 9.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4023) HSP20 PF00011.21 PIK54271.1 - 3.1e-17 62.6 0.2 6.9e-17 61.5 0.2 1.6 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Fib_alpha PF08702.10 PIK54272.1 - 0.0079 16.4 0.4 0.011 15.9 0.4 1.3 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family PKcGMP_CC PF16808.5 PIK54272.1 - 0.06 13.2 0.4 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mon1 PF03164.14 PIK54273.1 - 6.1e-72 242.9 1.4 8.3e-72 242.5 1.4 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 rve PF00665.26 PIK54274.1 - 2.8e-08 34.0 0.0 4.1e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain RPN7 PF10602.9 PIK54275.1 - 0.0075 16.0 0.0 0.0098 15.6 0.0 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 RAP1 PF07218.11 PIK54275.1 - 0.013 13.8 0.2 0.015 13.6 0.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Erp_C PF06780.11 PIK54275.1 - 0.084 12.9 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Erp protein C-terminus RVT_1 PF00078.27 PIK54276.1 - 1.9e-35 122.4 0.0 2.6e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK54277.1 - 7.6e-05 22.5 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK54277.1 - 0.0015 18.1 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pacifastin_I PF05375.13 PIK54278.1 - 0.099 12.4 6.5 0.28 10.9 4.9 2.1 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) DUF1068 PF06364.12 PIK54279.1 - 0.018 14.9 0.9 0.019 14.8 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Helicase_C PF00271.31 PIK54282.1 - 2.9e-12 46.9 0.1 7.7e-12 45.5 0.1 1.7 1 1 1 2 2 2 1 Helicase conserved C-terminal domain KDZ PF18758.1 PIK54283.1 - 3.2e-07 30.2 0.0 6.5e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK54283.1 - 4.1e-07 30.1 0.1 2.1e-06 27.9 0.1 2.2 1 1 1 2 2 2 1 CxC2 like cysteine cluster associated with KDZ transposases CxC1 PF18802.1 PIK54283.1 - 0.00051 20.2 0.1 0.0018 18.4 0.1 2.0 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases Transp_Tc5_C PF04236.15 PIK54283.1 - 0.0035 17.7 1.6 0.0081 16.5 1.6 1.5 1 0 0 1 1 1 1 Tc5 transposase C-terminal domain CxC3 PF18804.1 PIK54283.1 - 0.18 11.7 0.1 0.18 11.7 0.1 3.5 4 0 0 4 4 4 0 CxC3 like cysteine cluster associated with KDZ transposases GTF2I PF02946.14 PIK54284.1 - 9.5e-13 48.0 0.0 1.4e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 GTF2I-like repeat BOP1NT PF08145.12 PIK54285.1 - 6.6e-56 190.1 0.1 6.6e-56 190.1 0.1 2.1 2 0 0 2 2 2 1 BOP1NT (NUC169) domain CDC45 PF02724.14 PIK54285.1 - 1.3 7.2 16.5 1.8 6.8 16.5 1.1 1 0 0 1 1 1 0 CDC45-like protein BOP1NT PF08145.12 PIK54286.1 - 9.4e-26 91.3 6.2 1.4e-25 90.7 6.2 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 PIK54286.1 - 1.8e-21 76.0 5.3 1.8e-09 38.0 0.1 6.6 6 2 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK54286.1 - 2.4e-09 37.4 0.0 0.00088 19.5 0.0 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 PIK54286.1 - 0.05 12.7 0.0 1.2 8.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) 7tm_1 PF00001.21 PIK54287.1 - 3.7e-19 69.1 6.4 6.7e-19 68.2 6.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK54287.1 - 1e-05 25.0 4.1 1.6e-05 24.4 4.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw VID27_PH PF17747.1 PIK54288.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 VID27 PH-like domain Malate_DH PF12434.8 PIK54289.1 - 0.11 12.6 0.3 0.24 11.5 0.3 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme zf-DNA_Pol PF08996.10 PIK54289.1 - 0.18 11.6 2.0 0.3 10.8 2.0 1.3 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger Cyt-b5 PF00173.28 PIK54290.1 - 3.5e-15 55.9 0.0 6.9e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AIM3 PF17096.5 PIK54291.1 - 0.42 11.6 2.1 0.46 11.5 0.1 2.1 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 RCC1 PF00415.18 PIK54292.1 - 1e-87 288.6 27.2 4.3e-14 52.9 0.0 8.0 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK54292.1 - 4.5e-36 121.9 38.9 1.3e-07 31.2 0.1 8.7 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat Cul7 PF11515.8 PIK54292.1 - 5.3e-32 109.9 0.4 1.7e-31 108.3 0.4 2.0 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 MIB_HERC2 PF06701.13 PIK54292.1 - 2e-22 79.2 5.3 2e-22 79.2 5.3 3.8 4 0 0 4 4 3 1 Mib_herc2 ZZ PF00569.17 PIK54292.1 - 1.5e-10 40.7 4.7 3.4e-10 39.6 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type ANAPC10 PF03256.16 PIK54292.1 - 6.1e-10 39.0 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) SH3_15 PF18346.1 PIK54292.1 - 4.7e-05 23.6 0.8 4.7e-05 23.6 0.8 4.5 5 0 0 5 5 5 1 Mind bomb SH3 repeat domain Cwf_Cwc_15 PF04889.12 PIK54292.1 - 0.0019 18.0 1.2 0.0038 17.0 1.2 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein F5_F8_type_C PF00754.25 PIK54292.1 - 0.0047 17.1 0.0 0.015 15.4 0.0 1.8 1 0 0 1 1 1 1 F5/8 type C domain NUC205 PF08168.11 PIK54292.1 - 0.094 12.2 0.2 0.41 10.2 0.3 2.0 2 0 0 2 2 2 0 NUC205 domain DDE_Tnp_1_6 PF13751.6 PIK54292.1 - 1 9.6 3.5 21 5.3 0.6 2.7 2 0 0 2 2 2 0 Transposase DDE domain RCC1 PF00415.18 PIK54293.1 - 1.3e-69 230.6 29.2 2.4e-14 53.6 0.1 7.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK54293.1 - 7.8e-28 95.7 48.7 2.2e-07 30.5 1.5 8.7 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 PIK54294.1 - 1.6e-41 142.8 0.0 1.7e-40 139.4 0.0 1.9 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) FANCF PF11107.8 PIK54295.1 - 1.8e-27 96.5 2.4 1.9e-26 93.1 2.4 1.9 1 1 0 1 1 1 1 Fanconi anemia group F protein (FANCF) GIT_CC PF16559.5 PIK54295.1 - 0.00044 20.1 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor YvbH_ext PF11724.8 PIK54295.1 - 0.0017 18.6 0.2 0.0081 16.5 0.0 2.3 2 0 0 2 2 2 1 YvbH-like oligomerisation region THUMP PF02926.17 PIK54295.1 - 0.14 12.3 0.1 0.61 10.2 0.1 1.9 1 1 1 2 2 2 0 THUMP domain Ribonuc_red_lgC PF02867.15 PIK54296.1 - 3.5e-177 590.1 0.0 5.4e-177 589.5 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 PIK54296.1 - 1.1e-22 79.8 0.0 2.5e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 PIK54296.1 - 1.6e-16 60.6 0.1 4.2e-16 59.3 0.1 1.8 1 0 0 1 1 1 1 ATP cone domain CathepsinC_exc PF08773.11 PIK54296.1 - 0.074 13.3 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 Cathepsin C exclusion domain NTF2 PF02136.20 PIK54297.1 - 2.8e-16 60.2 0.2 1.3e-08 35.4 0.0 2.1 2 0 0 2 2 2 2 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 PIK54297.1 - 0.0075 16.2 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 1 Nuclear pore RNA shuttling protein Mtr2 Bromo_TP PF07524.13 PIK54298.1 - 6.2e-13 48.6 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 PIK54298.1 - 0.03 14.5 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 Histone-fold protein APH PF01636.23 PIK54299.1 - 2.6e-13 50.5 0.0 3.8e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 PIK54299.1 - 2.7e-08 33.5 0.1 4.4e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 PIK54299.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Neur_chan_LBD PF02931.23 PIK54300.1 - 4.5e-37 127.6 0.0 6.7e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK54300.1 - 1.1e-25 91.1 4.4 2.7e-23 83.3 2.0 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region PIG-P PF08510.12 PIK54300.1 - 0.48 10.4 4.6 0.92 9.4 2.4 2.5 2 1 0 2 2 2 0 PIG-P C2 PF00168.30 PIK54301.1 - 1e-21 77.1 1.9 1.6e-10 41.1 0.3 2.3 2 0 0 2 2 2 2 C2 domain Methyltransf_11 PF08241.12 PIK54302.1 - 6.7e-15 55.5 0.0 1.4e-14 54.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK54302.1 - 3.3e-13 49.8 0.0 6.1e-13 48.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK54302.1 - 1.1e-10 42.0 0.0 1.9e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK54302.1 - 9.9e-08 32.6 0.0 2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK54302.1 - 2.4e-07 30.7 0.1 3.5e-07 30.1 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK54302.1 - 2.7e-06 26.9 0.1 7.7e-05 22.1 0.1 2.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 PIK54302.1 - 0.0038 17.1 0.0 0.007 16.2 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase NodS PF05401.11 PIK54302.1 - 0.0066 16.1 0.0 0.0092 15.6 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_11 PF08241.12 PIK54303.1 - 3.6e-14 53.2 0.0 1.1e-13 51.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK54303.1 - 3.4e-13 49.7 0.0 4e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK54303.1 - 1.1e-10 42.1 0.0 1.9e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK54303.1 - 1.9e-08 34.9 0.0 3.5e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK54303.1 - 1.2e-07 31.7 0.1 7.7e-07 29.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK54303.1 - 1.3e-05 24.6 0.1 0.0002 20.8 0.1 2.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 PIK54303.1 - 0.0024 17.8 0.0 0.01 15.7 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase NodS PF05401.11 PIK54303.1 - 0.013 15.1 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.12 PIK54303.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RrnaAD PF00398.20 PIK54303.1 - 0.085 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF1943 PF09172.11 PIK54304.1 - 0.17 11.1 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Pkinase_Tyr PF07714.17 PIK54305.1 - 7.1e-67 225.4 0.0 1.1e-66 224.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK54305.1 - 2.1e-23 83.0 0.0 2.9e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 PIK54306.1 - 4.1e-09 36.7 0.8 0.0026 18.1 0.0 2.9 2 0 0 2 2 2 2 Fibronectin type III domain DUF3060 PF11259.8 PIK54306.1 - 0.35 10.6 11.8 47 3.8 0.1 5.8 4 1 1 6 6 6 0 Protein of unknown function (DUF3060) RVT_1 PF00078.27 PIK54307.1 - 3.5e-19 69.2 0.3 3.9e-19 69.1 0.3 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exonuc_VII_L PF02601.15 PIK54308.1 - 2.8 7.4 8.3 3.4 7.2 8.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit fn3 PF00041.21 PIK54309.1 - 0.0031 17.8 1.6 2.4 8.6 0.1 2.9 2 1 0 2 2 2 2 Fibronectin type III domain Glyco_hydro_30 PF02055.16 PIK54310.1 - 1.1e-142 475.2 3.5 1.4e-142 474.8 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 PIK54310.1 - 1.4e-09 38.0 0.1 3.7e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 PIK54310.1 - 1.1e-07 31.5 0.3 1.7e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Ank_2 PF12796.7 PIK54311.1 - 6e-49 164.6 11.2 7.3e-19 68.2 0.6 4.6 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54311.1 - 8.3e-37 125.1 6.6 1.5e-12 47.7 0.1 6.9 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54311.1 - 2e-36 119.9 6.4 0.0002 21.6 0.1 8.7 8 0 0 8 8 8 8 Ankyrin repeat Ank PF00023.30 PIK54311.1 - 1.8e-32 110.4 13.8 9e-06 25.9 0.2 8.0 7 1 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 PIK54311.1 - 2.5e-32 110.5 5.4 1.1e-09 38.3 0.1 7.6 3 1 4 7 7 7 6 Ankyrin repeats (many copies) DUF1843 PF08898.10 PIK54311.1 - 0.097 13.2 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) Flavoprotein PF02441.19 PIK54312.1 - 2.9e-38 131.1 0.0 3.4e-38 130.9 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein SKG6 PF08693.10 PIK54313.1 - 0.0057 16.0 3.3 0.0057 16.0 3.3 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF4719 PF15843.5 PIK54313.1 - 0.02 15.0 2.6 0.02 15.0 2.6 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4719) IMUP PF15761.5 PIK54313.1 - 2.3 8.9 11.6 0.098 13.4 5.6 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF4512 PF14975.6 PIK54313.1 - 6.8 7.5 6.3 9.4 7.1 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Na_trans_assoc PF06512.13 PIK54315.1 - 0.0046 17.3 3.1 0.0058 16.9 3.1 1.2 1 0 0 1 1 1 1 Sodium ion transport-associated Ribosomal_60s PF00428.19 PIK54315.1 - 0.022 15.3 8.3 0.022 15.3 8.3 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cwf_Cwc_15 PF04889.12 PIK54315.1 - 0.46 10.2 8.2 0.63 9.7 8.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3145 PF11343.8 PIK54316.1 - 0.16 11.5 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) MAM PF00629.23 PIK54317.1 - 8e-63 211.1 0.0 3.7e-30 104.9 0.0 2.2 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu EGF PF00008.27 PIK54317.1 - 5e-11 42.7 18.4 2.9e-07 30.7 5.6 2.6 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.15 PIK54317.1 - 0.0032 17.6 28.0 0.018 15.2 8.0 2.8 3 0 0 3 3 3 2 Calcium-binding EGF domain hEGF PF12661.7 PIK54317.1 - 0.039 14.6 18.0 0.13 13.0 5.2 3.4 3 0 0 3 3 3 0 Human growth factor-like EGF Laminin_EGF PF00053.24 PIK54317.1 - 0.63 10.2 18.3 7.1 6.9 5.6 2.8 1 1 1 2 2 2 0 Laminin EGF domain FXa_inhibition PF14670.6 PIK54317.1 - 0.66 10.3 14.2 1.1 9.6 4.7 2.6 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK54317.1 - 4.8 7.2 19.4 0.053 13.5 1.4 4.0 3 0 0 3 3 3 0 Complement Clr-like EGF-like Sulfatase PF00884.23 PIK54318.1 - 3.1e-44 151.6 0.0 4.1e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK54318.1 - 0.018 15.8 0.0 0.057 14.2 0.0 1.8 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF229 PF02995.17 PIK54318.1 - 0.19 10.3 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) rve_3 PF13683.6 PIK54319.1 - 2.2e-09 37.0 0.0 7.1e-09 35.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve PF00665.26 PIK54319.1 - 2.7e-05 24.3 0.0 4.9e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 PIK54319.1 - 0.0011 19.0 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Abhydrolase_1 PF00561.20 PIK54320.1 - 3.3e-10 40.0 0.0 1.9e-09 37.6 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK54320.1 - 1.7e-05 25.5 0.0 2.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 PIK54320.1 - 0.00075 19.7 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 PIK54320.1 - 0.0013 18.1 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 PIK54320.1 - 0.006 16.4 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 PIK54320.1 - 0.009 14.7 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Ndr family UPF0227 PF05728.12 PIK54320.1 - 0.031 14.2 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Cohesin_load PF10345.9 PIK54321.1 - 2.5e-84 283.8 17.4 4.6e-84 283.0 17.4 1.4 1 1 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 PIK54321.1 - 4.3e-06 26.9 9.3 0.2 11.9 0.0 5.9 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK54321.1 - 1.7e-05 25.3 1.3 0.02 15.7 0.1 5.3 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK54321.1 - 1.8e-05 24.6 6.7 2.6 8.5 0.1 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54321.1 - 2.2e-05 24.2 6.3 13 6.2 0.0 7.2 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK54321.1 - 0.00012 21.9 6.8 0.12 12.1 0.5 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 PIK54321.1 - 0.00043 19.8 15.9 0.032 13.6 0.0 3.5 2 1 0 2 2 2 2 MalT-like TPR region TPR_10 PF13374.6 PIK54321.1 - 0.003 17.4 1.4 15 5.7 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK54321.1 - 0.0045 17.5 9.1 0.022 15.2 0.1 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK54321.1 - 0.73 10.1 6.2 4.7 7.5 0.9 3.8 2 2 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK54321.1 - 0.84 9.8 12.5 41 4.5 0.2 6.1 7 1 0 7 7 7 0 Tetratricopeptide repeat GATA PF00320.27 PIK54322.1 - 2.5e-07 30.2 0.7 5.2e-07 29.2 0.7 1.6 1 0 0 1 1 1 1 GATA zinc finger P66_CC PF16563.5 PIK54322.1 - 0.014 15.0 3.9 0.014 15.0 3.9 3.4 3 0 0 3 3 3 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Beta_helix PF13229.6 PIK54322.1 - 0.05 13.5 2.4 0.065 13.1 0.1 2.0 2 0 0 2 2 2 0 Right handed beta helix region C1_1 PF00130.22 PIK54322.1 - 0.18 11.7 1.4 0.33 10.9 1.4 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HECT PF00632.25 PIK54323.1 - 5.2e-92 308.6 0.0 6.8e-92 308.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 PIK54323.1 - 8.2e-38 128.2 8.9 4.8e-13 48.9 0.4 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 PIK54323.1 - 4.6e-22 78.2 0.1 9.8e-22 77.2 0.1 1.6 1 0 0 1 1 1 1 C2 domain FerI PF08151.12 PIK54323.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 FerI (NUC094) domain YjeF_N PF03853.15 PIK54324.1 - 1.1e-15 58.0 0.0 1.7e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 PIK54324.1 - 9.6e-06 26.4 3.4 1.6e-05 25.7 3.4 1.3 1 0 0 1 1 1 1 FDF domain DUF5096 PF17019.5 PIK54324.1 - 2.2e-05 24.3 0.0 4.9e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5096) Synthase_beta PF11421.8 PIK54325.1 - 0.25 12.1 0.4 0.25 12.1 0.4 2.8 3 0 0 3 3 3 0 ATP synthase F1 beta subunit WD40 PF00400.32 PIK54327.1 - 1.1e-21 76.7 19.8 0.0011 19.7 0.6 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK54327.1 - 1.1e-09 38.5 0.0 0.02 15.2 0.0 4.6 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 PIK54327.1 - 0.029 13.1 0.0 0.057 12.2 0.0 1.4 1 0 0 1 1 1 0 Nup133 N terminal like Nup160 PF11715.8 PIK54327.1 - 0.046 12.4 0.2 1.2 7.7 0.2 2.3 1 1 0 1 1 1 0 Nucleoporin Nup120/160 WD40_like PF17005.5 PIK54327.1 - 0.14 11.4 0.0 13 4.9 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain Cytochrom_D1 PF02239.16 PIK54327.1 - 0.15 10.6 0.0 5.9 5.3 0.0 2.7 2 1 0 3 3 3 0 Cytochrome D1 heme domain Pkinase_Tyr PF07714.17 PIK54329.1 - 9.3e-22 77.5 0.1 9.8e-22 77.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK54329.1 - 2.1e-14 53.5 0.1 2.4e-14 53.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain NigD_C PF17415.2 PIK54329.1 - 0.095 12.8 0.0 0.28 11.2 0.0 1.7 2 0 0 2 2 2 0 NigD-like C-terminal beta sandwich domain Laminin_EGF PF00053.24 PIK54330.1 - 4.7e-15 55.5 119.4 0.011 15.9 12.5 7.6 3 2 4 7 7 7 6 Laminin EGF domain hEGF PF12661.7 PIK54330.1 - 0.00026 21.5 28.0 0.0058 17.2 3.6 9.2 8 2 0 8 8 8 5 Human growth factor-like EGF DSL PF01414.19 PIK54330.1 - 0.0015 18.7 117.3 0.051 13.9 15.1 6.5 6 0 0 6 6 6 4 Delta serrate ligand EGF_2 PF07974.13 PIK54330.1 - 3.6 8.0 143.2 0.044 14.2 12.6 10.8 8 4 2 10 10 10 0 EGF-like domain Laminin_EGF PF00053.24 PIK54331.1 - 8.7e-31 105.8 156.9 0.00022 21.3 14.2 9.3 1 1 8 9 9 9 9 Laminin EGF domain EGF_2 PF07974.13 PIK54331.1 - 9.6e-14 51.5 185.7 0.0063 16.8 16.2 16.8 11 5 4 15 15 15 10 EGF-like domain DSL PF01414.19 PIK54331.1 - 6.4e-05 23.1 166.1 0.032 14.5 17.4 9.3 6 2 2 8 8 8 7 Delta serrate ligand hEGF PF12661.7 PIK54331.1 - 0.013 16.1 18.3 0.032 14.9 4.4 14.0 11 3 4 15 15 15 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 PIK54331.1 - 0.044 13.8 0.9 0.044 13.8 0.9 12.6 7 6 4 11 11 11 0 Tenascin EGF domain RVT_1 PF00078.27 PIK54332.1 - 5e-37 127.6 0.2 9.1e-37 126.7 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Laminin_EGF PF00053.24 PIK54333.1 - 4.4e-30 103.6 181.1 0.00017 21.6 17.9 10.8 4 3 6 10 10 10 9 Laminin EGF domain EGF_2 PF07974.13 PIK54333.1 - 9.7e-18 64.2 226.7 0.00055 20.2 14.9 16.5 10 8 6 16 16 16 8 EGF-like domain DSL PF01414.19 PIK54333.1 - 2.5e-06 27.6 194.0 0.0022 18.2 15.7 9.8 8 2 1 9 9 9 5 Delta serrate ligand hEGF PF12661.7 PIK54333.1 - 1.7e-05 25.2 37.3 0.00023 21.6 9.0 14.5 16 2 0 16 16 16 7 Human growth factor-like EGF EGF PF00008.27 PIK54333.1 - 0.012 15.9 11.5 0.012 15.9 11.5 14.0 13 1 0 13 13 13 0 EGF-like domain GRDB PF07355.12 PIK54333.1 - 7.1 5.8 7.8 3.2 6.9 0.8 2.9 3 0 0 3 3 3 0 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) tRNA_SAD PF07973.14 PIK54334.1 - 4.1e-08 33.2 1.6 4.1e-08 33.2 0.1 1.8 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 PIK54334.1 - 0.0089 14.6 0.0 0.013 14.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) AICARFT_IMPCHas PF01808.18 PIK54335.1 - 2.3e-72 243.9 0.0 3.6e-61 207.2 0.0 2.6 2 1 1 3 3 3 2 AICARFT/IMPCHase bienzyme MGS PF02142.22 PIK54335.1 - 5.6e-21 74.5 0.0 1.5e-20 73.2 0.0 1.8 1 0 0 1 1 1 1 MGS-like domain TIR_2 PF13676.6 PIK54336.1 - 1.3e-11 45.1 0.0 2.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 TIR domain Death PF00531.22 PIK54336.1 - 3.3e-08 33.6 0.5 8.4e-08 32.3 0.5 1.6 1 0 0 1 1 1 1 Death domain TIR PF01582.20 PIK54336.1 - 3.7e-08 33.4 0.0 9.6e-08 32.0 0.0 1.7 1 1 0 1 1 1 1 TIR domain HLH PF00010.26 PIK54337.1 - 7.1e-15 54.7 0.0 1.7e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAP_assoc PF03828.19 PIK54337.1 - 0.00045 20.4 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase Nrap_D2 PF17403.2 PIK54337.1 - 0.0024 17.6 1.0 0.0074 16.1 0.1 2.1 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain LMBR1 PF04791.16 PIK54337.1 - 0.031 13.2 1.2 0.043 12.7 1.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein bZIP_2 PF07716.15 PIK54337.1 - 5.2 7.2 8.6 5.7 7.1 1.3 2.5 2 0 0 2 2 2 0 Basic region leucine zipper RL PF17797.1 PIK54338.1 - 1.7e-19 69.5 0.1 3e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 RL domain AOX PF01786.17 PIK54339.1 - 3.6e-93 311.1 0.0 4.4e-93 310.8 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase Rab5ip PF07019.12 PIK54340.1 - 4.8e-11 43.1 0.1 6e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) CytB6-F_Fe-S PF08802.10 PIK54340.1 - 0.91 9.6 6.1 0.44 10.6 2.5 2.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit SWIRM-assoc_2 PF16496.5 PIK54341.1 - 3.3e-48 164.6 0.0 3.6e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal SWIRM-assoc_2 PF16496.5 PIK54342.1 - 1.7e-95 320.3 17.0 1.7e-95 320.3 17.0 3.7 3 1 0 3 3 3 1 SWIRM-associated domain at the N-terminal SWIRM-assoc_1 PF16495.5 PIK54342.1 - 7e-30 102.8 17.0 7e-30 102.8 17.0 2.8 2 0 0 2 2 2 1 SWIRM-associated region 1 SWIRM-assoc_3 PF16498.5 PIK54342.1 - 1.3e-22 79.8 0.2 1.3e-22 79.8 0.2 3.5 4 0 0 4 4 4 1 SWIRM-associated domain at the C-terminal SWIRM PF04433.17 PIK54342.1 - 8.4e-08 32.5 2.1 0.0015 18.8 0.0 3.1 2 1 1 3 3 3 2 SWIRM domain RskA PF10099.9 PIK54342.1 - 0.004 17.5 7.8 0.004 17.5 7.8 3.6 3 1 0 3 3 3 2 Anti-sigma-K factor rskA Myb_DNA-binding PF00249.31 PIK54342.1 - 0.016 15.4 0.4 0.067 13.4 0.4 2.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glutaredoxin PF00462.24 PIK54342.1 - 0.065 13.5 0.1 0.21 11.8 0.1 1.9 1 0 0 1 1 1 0 Glutaredoxin BRCT_2 PF16589.5 PIK54342.1 - 0.097 13.1 0.0 0.42 11.1 0.0 2.2 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF919 PF06034.11 PIK54342.1 - 0.17 11.7 4.9 0.53 10.1 4.9 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Sema PF01403.19 PIK54343.1 - 2.2e-68 231.0 0.1 2.8e-68 230.7 0.1 1.0 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.19 PIK54344.1 - 3.6e-19 68.7 31.4 4.2e-14 52.5 10.9 4.4 5 0 0 5 5 5 3 Thrombospondin type 1 domain PSI PF01437.25 PIK54344.1 - 2e-06 28.2 1.8 2e-06 28.2 1.8 4.1 2 1 1 3 3 3 1 Plexin repeat DUF4404 PF14357.6 PIK54345.1 - 0.041 14.5 0.6 0.088 13.5 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) NACHT PF05729.12 PIK54346.1 - 1.3e-11 44.7 0.0 5.9e-11 42.6 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK54346.1 - 0.0059 16.2 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain UNC45-central PF11701.8 PIK54346.1 - 0.08 12.9 1.4 0.29 11.1 0.0 2.6 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central NACHT PF05729.12 PIK54347.1 - 5.4e-12 45.9 0.0 1.3e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK54347.1 - 0.0044 16.6 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK54347.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 PH PF00169.29 PIK54348.1 - 6.5e-08 33.0 1.0 8.8e-08 32.6 0.3 1.6 2 0 0 2 2 2 1 PH domain zf-C2H2 PF00096.26 PIK54349.1 - 7.8e-09 35.5 1.9 3.4e-05 24.1 0.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 PIK54349.1 - 1.6e-05 24.8 7.1 0.014 15.4 0.4 2.7 2 1 1 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 PIK54349.1 - 1.9e-05 25.1 2.6 0.13 13.2 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK54349.1 - 0.00019 21.6 4.6 0.021 15.1 0.1 2.9 2 1 1 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK54349.1 - 0.0017 18.7 15.8 0.19 12.2 0.7 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-CRD PF17979.1 PIK54349.1 - 0.0018 18.4 0.6 0.0021 18.2 0.6 1.1 1 0 0 1 1 1 1 Cysteine rich domain with multizinc binding regions XPA_N PF01286.18 PIK54349.1 - 0.0019 18.2 1.4 0.048 13.7 0.0 2.3 2 0 0 2 2 2 1 XPA protein N-terminal zf-met PF12874.7 PIK54349.1 - 0.013 15.9 4.3 2 8.9 0.2 2.8 2 1 1 3 3 3 0 Zinc-finger of C2H2 type C1_4 PF07975.12 PIK54349.1 - 0.019 15.2 1.6 0.047 13.9 1.2 1.8 1 1 1 2 2 2 0 TFIIH C1-like domain FYVE PF01363.21 PIK54349.1 - 0.023 14.8 1.2 0.046 13.9 1.2 1.6 1 1 0 1 1 1 0 FYVE zinc finger Ta0938 PF11494.8 PIK54349.1 - 0.033 14.5 0.1 0.038 14.3 0.1 1.2 1 0 0 1 1 1 0 Ta0938 zf-AN1 PF01428.16 PIK54349.1 - 0.049 13.8 2.4 4.4 7.5 0.1 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zf-met2 PF12907.7 PIK54349.1 - 0.054 13.6 1.0 2.2 8.5 0.1 2.4 2 0 0 2 2 2 0 Zinc-binding zf_UBZ PF18439.1 PIK54349.1 - 0.091 12.4 0.7 9.4 5.9 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 PIK54349.1 - 0.13 12.4 6.2 0.18 11.9 4.1 2.2 2 1 1 3 3 3 0 Zinc ribbon domain MEIOC PF15189.6 PIK54350.1 - 1.8e-34 118.7 0.0 2.8e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC HnRNP_M PF11532.8 PIK54350.1 - 0.15 12.3 0.2 0.32 11.3 0.2 1.5 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein M DnaJ PF00226.31 PIK54351.1 - 8.7e-15 54.6 0.1 8.7e-15 54.6 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain Pneumovirus_M2 PF06436.11 PIK54351.1 - 0.034 13.7 0.0 0.074 12.5 0.0 1.7 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) Calpain_inhib PF00748.19 PIK54351.1 - 0.057 13.9 9.9 0.1 13.1 9.9 1.4 1 0 0 1 1 1 0 Calpain inhibitor Bac_luciferase PF00296.20 PIK54351.1 - 0.11 11.9 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Luciferase-like monooxygenase DUF1266 PF06889.11 PIK54351.1 - 0.69 9.9 7.6 0.28 11.2 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Bax1-I PF01027.20 PIK54352.1 - 8.4e-42 143.3 22.1 9.6e-42 143.1 22.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 PIK54352.1 - 0.0065 16.1 18.6 0.013 15.1 18.6 1.5 1 1 0 1 1 1 1 Bax inhibitor 1 like ArfGap PF01412.18 PIK54353.1 - 3.4e-25 88.4 0.4 3.4e-25 88.4 0.4 1.9 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 PIK54353.1 - 0.0014 19.1 0.0 0.0026 18.3 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 PIK54353.1 - 0.0088 16.3 0.8 0.013 15.8 0.1 1.6 2 0 0 2 2 2 1 Pleckstrin homology domain Ras PF00071.22 PIK54354.1 - 2.3e-17 63.1 0.0 4.1e-17 62.3 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK54354.1 - 0.0004 20.6 0.0 0.058 13.6 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 PIK54354.1 - 0.022 14.1 0.0 3.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Spore_IV_A PF09547.10 PIK54354.1 - 0.06 12.3 0.0 0.089 11.7 0.0 1.2 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) AAA_22 PF13401.6 PIK54354.1 - 0.13 12.5 0.0 19 5.5 0.0 2.1 1 1 1 2 2 2 0 AAA domain RT_RNaseH PF17917.1 PIK54355.1 - 0.00081 19.6 0.0 0.15 12.4 0.0 2.4 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Calponin PF00402.18 PIK54357.1 - 0.00012 21.6 0.3 69 3.2 0.0 6.9 6 2 1 8 8 8 1 Calponin family repeat RII_binding_1 PF10522.9 PIK54357.1 - 0.063 13.5 0.3 2.6e+02 2.3 0.0 5.6 8 0 0 8 8 8 0 RII binding domain Reo_sigma1 PF01664.16 PIK54358.1 - 0.0027 17.0 0.3 4.2 6.6 0.0 3.0 1 1 2 3 3 3 2 Reovirus viral attachment protein sigma 1 BetaGal_dom2 PF10435.9 PIK54358.1 - 0.0069 16.2 0.2 2.5 7.9 0.0 3.3 2 1 2 4 4 4 1 Beta-galactosidase, domain 2 DUF2345 PF10106.9 PIK54359.1 - 0.0083 16.0 0.6 4.6 7.1 0.2 2.6 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2345) CutC PF03932.14 PIK54359.1 - 0.24 10.9 2.0 5.5 6.4 0.4 2.2 1 1 1 2 2 2 0 CutC family Peptidase_M14 PF00246.24 PIK54360.1 - 4e-71 240.2 1.1 4.6e-71 240.0 1.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK54360.1 - 1.8e-17 63.5 0.0 5.2e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase activation peptide cEGF PF12662.7 PIK54360.1 - 0.16 11.9 0.4 0.61 10.1 0.3 2.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like UPF0061 PF02696.14 PIK54361.1 - 6.8e-120 401.0 2.2 3.1e-118 395.5 2.2 2.1 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Thioredoxin_4 PF13462.6 PIK54361.1 - 0.0057 16.8 0.3 0.013 15.7 0.3 1.5 1 0 0 1 1 1 1 Thioredoxin TniB PF05621.11 PIK54361.1 - 0.062 12.7 0.2 0.12 11.8 0.2 1.4 1 0 0 1 1 1 0 Bacterial TniB protein DSS1_SEM1 PF05160.13 PIK54362.1 - 1.5e-22 79.4 20.3 2e-22 79.0 20.3 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.8 PIK54362.1 - 0.11 12.4 4.5 0.12 12.2 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) DNA_pol_phi PF04931.13 PIK54362.1 - 4.4 5.3 12.1 4.8 5.2 12.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi Acetyltransf_2 PF00797.17 PIK54363.1 - 5.3e-10 39.5 0.0 6.4e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Lectin_C PF00059.21 PIK54364.1 - 2.7e-67 224.3 17.7 5.3e-19 68.9 0.8 4.2 4 0 0 4 4 4 4 Lectin C-type domain UL45 PF05473.12 PIK54364.1 - 3e-10 40.1 2.3 0.00045 19.9 0.1 4.1 2 1 1 3 3 3 2 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 PIK54364.1 - 0.0025 18.2 0.2 6.3 7.3 0.1 3.8 3 1 0 3 3 3 1 Extracellular link domain DUF2434 PF10361.9 PIK54364.1 - 0.047 12.7 0.4 0.077 12.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) DUF5326 PF17260.2 PIK54364.1 - 0.082 13.0 0.4 0.18 11.9 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5326) CD20 PF04103.15 PIK54365.1 - 0.0013 18.8 7.4 0.0013 18.8 7.4 2.6 2 1 1 3 3 3 1 CD20-like family Spore_III_AB PF09548.10 PIK54365.1 - 1 9.4 3.9 0.37 10.9 0.4 1.9 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) MYCBPAP PF14646.6 PIK54366.1 - 3.6e-109 365.6 0.3 3.3e-101 339.4 0.0 2.1 1 1 1 2 2 2 2 MYCBP-associated protein family CDC45 PF02724.14 PIK54366.1 - 0.47 8.7 6.0 0.76 8.0 6.0 1.2 1 0 0 1 1 1 0 CDC45-like protein PEMT PF04191.13 PIK54367.1 - 2.7e-29 101.7 4.4 2.7e-29 101.7 4.4 1.7 2 1 1 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 PIK54367.1 - 0.074 13.5 0.4 0.074 13.5 0.4 2.0 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF202 PF02656.15 PIK54367.1 - 5.3 7.6 9.4 21 5.6 0.3 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF202) HLH PF00010.26 PIK54368.1 - 5.5e-10 39.1 0.6 9e-10 38.4 0.6 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain YlbD_coat PF14071.6 PIK54368.1 - 0.0055 16.9 0.6 0.0075 16.5 0.0 1.4 2 0 0 2 2 2 1 Putative coat protein BNIP3 PF06553.12 PIK54368.1 - 0.015 15.0 5.6 0.022 14.4 5.6 1.2 1 0 0 1 1 1 0 BNIP3 eIF3_N PF09440.10 PIK54370.1 - 0.059 13.8 2.2 0.068 13.6 2.2 1.2 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain HTH_41 PF14502.6 PIK54370.1 - 0.13 12.0 0.0 0.88 9.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HRG PF16954.5 PIK54371.1 - 1.8e-17 63.5 19.9 1.1e-11 44.9 3.4 2.8 2 1 0 2 2 2 2 Haem-transporter, endosomal/lysosomal, haem-responsive gene PNTB PF02233.16 PIK54371.1 - 0.039 12.9 0.0 0.044 12.7 0.0 1.0 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit Pkinase PF00069.25 PIK54372.1 - 1e-05 25.1 1.1 2.2e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain BSP_II PF05432.11 PIK54372.1 - 0.0013 18.5 3.9 0.0015 18.3 3.9 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) IFRD PF05004.13 PIK54372.1 - 0.0021 17.2 1.5 0.0028 16.8 1.5 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Nop53 PF07767.11 PIK54372.1 - 0.0043 16.5 7.9 0.005 16.3 7.9 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DNA_pol_phi PF04931.13 PIK54372.1 - 0.0072 14.5 3.8 0.0076 14.4 3.8 1.3 1 0 0 1 1 1 1 DNA polymerase phi DUF3381 PF11861.8 PIK54372.1 - 0.009 15.8 9.8 0.011 15.5 9.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3381) NOA36 PF06524.12 PIK54372.1 - 0.0095 15.3 4.5 0.0095 15.3 4.5 1.4 2 0 0 2 2 2 1 NOA36 protein Myc_N PF01056.18 PIK54372.1 - 0.011 15.7 2.3 0.012 15.6 2.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF2262 PF10020.9 PIK54372.1 - 0.039 14.3 2.6 0.047 14.1 2.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) Cyt_b-c1_8 PF10890.8 PIK54372.1 - 0.044 14.2 0.1 0.34 11.4 0.0 2.1 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 CENP-B_dimeris PF09026.10 PIK54372.1 - 0.045 14.1 7.9 0.068 13.6 7.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 PIK54372.1 - 0.046 12.0 6.0 0.053 11.8 6.0 1.0 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 PIK54372.1 - 0.09 13.1 5.9 0.11 12.7 5.9 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PIEZO PF15917.5 PIK54372.1 - 0.11 12.0 5.0 0.14 11.6 5.0 1.1 1 0 0 1 1 1 0 Piezo FAM176 PF14851.6 PIK54372.1 - 0.22 11.2 8.9 0.41 10.3 8.9 1.4 1 0 0 1 1 1 0 FAM176 family FAM163 PF15069.6 PIK54372.1 - 0.53 10.7 2.5 0.75 10.2 2.5 1.1 1 0 0 1 1 1 0 FAM163 family DUF4611 PF15387.6 PIK54372.1 - 0.82 9.9 9.9 1.2 9.4 9.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) DUF3169 PF11368.8 PIK54372.1 - 1 8.8 3.3 1.6 8.2 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Sec62 PF03839.16 PIK54372.1 - 1.6 8.2 5.5 1.9 8.0 4.7 1.4 2 0 0 2 2 2 0 Translocation protein Sec62 DUF4637 PF15470.6 PIK54372.1 - 7 6.4 9.1 9.5 5.9 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Spt5_N PF11942.8 PIK54372.1 - 7.9 7.5 19.4 17 6.4 19.4 1.5 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Pkinase PF00069.25 PIK54373.1 - 2.1e-57 194.5 0.0 2.4e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54373.1 - 7.8e-32 110.6 0.0 9.6e-32 110.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK54373.1 - 2.9e-05 24.1 0.0 0.0011 18.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 PIK54373.1 - 0.00031 20.1 0.1 0.00089 18.7 0.1 2.0 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK54373.1 - 0.00092 18.2 0.1 0.072 12.0 0.0 2.0 2 0 0 2 2 2 2 Haspin like kinase domain Kdo PF06293.14 PIK54373.1 - 0.00095 18.6 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK54373.1 - 0.0011 18.7 0.1 0.0024 17.5 0.1 1.5 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 PIK54373.1 - 0.0017 17.9 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 PIK54373.1 - 0.046 13.3 0.1 1 9.0 0.0 2.2 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 PIK54373.1 - 0.086 11.6 0.9 0.52 9.0 0.1 2.3 2 1 0 3 3 3 0 Fungal protein kinase DFP PF04127.15 PIK54374.1 - 8e-22 78.0 0.1 1.5e-11 44.5 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein SOR PF07682.11 PIK54374.1 - 0.04 12.8 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 Sulphur oxygenase reductase Kazal_1 PF00050.21 PIK54375.1 - 5.9e-47 157.5 51.8 1.5e-09 37.7 4.1 5.7 5 0 0 5 5 5 5 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK54375.1 - 3e-39 132.9 52.7 1.3e-08 34.8 3.7 5.6 5 0 0 5 5 5 5 Kazal-type serine protease inhibitor domain zf-HC5HC2H PF13771.6 PIK54375.1 - 0.61 10.4 38.7 0.96 9.8 1.9 5.2 4 1 1 5 5 5 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 PIK54375.1 - 1.2 9.4 24.6 5.2 7.3 0.6 4.9 2 1 1 5 5 5 0 PHD-zinc-finger like domain Kazal_1 PF00050.21 PIK54376.1 - 8.7e-69 227.4 96.7 1.8e-09 37.4 5.8 9.0 4 3 4 8 8 8 8 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK54376.1 - 7e-64 211.8 112.5 4.2e-08 33.2 6.9 8.6 8 0 0 8 8 8 8 Kazal-type serine protease inhibitor domain Defensin_big PF14862.6 PIK54376.1 - 3.7e-06 27.1 36.5 0.82 10.0 0.1 7.8 8 0 0 8 8 8 6 Big defensin Pullulanase_Ins PF18494.1 PIK54376.1 - 0.023 15.2 17.2 56 4.3 0.1 7.4 7 0 0 7 7 7 0 Pullulanase Ins domain Complex1_51K PF01512.17 PIK54376.1 - 0.27 11.1 7.7 6.6 6.6 0.0 5.1 1 1 6 7 7 7 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit MIP PF00230.20 PIK54377.1 - 1.9e-09 37.6 1.6 2.2e-09 37.4 1.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF4282 PF14110.6 PIK54377.1 - 0.41 11.4 3.2 4.5 8.1 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) zf-C2H2 PF00096.26 PIK54379.1 - 2.9e-17 62.1 24.2 4.2e-05 23.8 0.4 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK54379.1 - 1.5e-15 56.8 20.1 1.1e-06 28.8 0.2 5.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54379.1 - 1e-11 44.6 20.6 0.031 15.1 1.2 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 PIK54379.1 - 0.0058 16.8 6.9 1.5 9.0 2.5 3.0 2 1 1 3 3 3 2 Aberrant zinc-finger CCAP PF11105.8 PIK54379.1 - 0.012 15.6 4.1 1.3 9.0 0.8 2.4 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a Raffinose_syn PF05691.12 PIK54379.1 - 0.025 12.4 0.0 0.045 11.5 0.0 1.4 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 IBR PF01485.21 PIK54379.1 - 0.03 14.5 1.6 0.03 14.5 1.6 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Transpos_assoc PF13963.6 PIK54379.1 - 0.039 14.3 3.4 0.81 10.0 0.1 2.9 2 1 1 3 3 3 0 Transposase-associated domain zinc_ribbon_9 PF14369.6 PIK54379.1 - 0.098 12.9 2.6 2.6 8.4 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon zf-TRAF PF02176.18 PIK54379.1 - 0.12 13.0 12.1 6.4 7.5 0.1 3.3 1 1 2 3 3 3 0 TRAF-type zinc finger FOXP-CC PF16159.5 PIK54379.1 - 0.13 12.9 10.5 1.4 9.6 3.0 2.9 2 0 0 2 2 2 0 FOXP coiled-coil domain CHORD PF04968.12 PIK54379.1 - 0.2 12.4 11.7 12 6.7 2.9 3.7 1 1 2 3 3 3 0 CHORD DUF3268 PF11672.8 PIK54379.1 - 0.37 11.1 2.9 4 7.8 0.2 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain zf-CGNR PF11706.8 PIK54379.1 - 0.45 10.4 6.5 6.6 6.7 0.4 3.2 3 1 0 3 3 3 0 CGNR zinc finger Med3 PF11593.8 PIK54379.1 - 1.1 8.4 9.3 2 7.5 9.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-met PF12874.7 PIK54379.1 - 1.8 9.1 7.5 1.4 9.4 0.5 3.0 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK54379.1 - 2.2 8.1 8.1 4.3 7.2 0.4 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK54379.1 - 2.8 8.3 18.1 0.22 11.9 0.6 3.9 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding ZFYVE21_C PF16696.5 PIK54380.1 - 3.7e-23 81.7 0.1 4.7e-23 81.4 0.1 1.1 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus FYVE PF01363.21 PIK54380.1 - 5.4e-17 61.7 13.7 1e-16 60.8 13.7 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH_12 PF16457.5 PIK54380.1 - 0.02 15.4 0.0 0.037 14.6 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain ABC1 PF03109.16 PIK54381.1 - 1.5e-33 115.5 0.1 1.1e-32 112.7 0.0 2.3 2 0 0 2 2 2 1 ABC1 family WaaY PF06176.11 PIK54381.1 - 0.0011 18.6 0.2 0.0029 17.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) MFS_1 PF07690.16 PIK54382.1 - 2.8e-13 49.5 15.6 2.8e-13 49.5 15.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 PIK54383.1 - 8.9e-20 70.9 49.3 5.1e-19 68.4 27.5 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MinC_C PF03775.16 PIK54383.1 - 0.13 12.2 0.7 2.3 8.3 0.1 2.7 2 1 1 3 3 3 0 Septum formation inhibitor MinC, C-terminal domain Sm_multidrug_ex PF06695.11 PIK54383.1 - 4.2 8.0 10.8 0.055 14.1 1.2 3.0 3 1 0 3 3 3 0 Putative small multi-drug export protein DUF4574 PF15141.6 PIK54384.1 - 2.2e-06 27.5 0.0 2.4e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 CBP4 PF07960.11 PIK54384.1 - 0.051 13.4 0.0 0.068 13.0 0.0 1.3 1 1 0 1 1 1 0 CBP4 Imm51 PF15595.6 PIK54384.1 - 0.12 12.3 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 51 DUF4508 PF14969.6 PIK54385.1 - 1.3e-31 108.7 3.2 1.5e-31 108.5 3.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) DUF2158 PF09926.9 PIK54385.1 - 0.23 11.2 1.7 3.7 7.4 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) DUF4611 PF15387.6 PIK54386.1 - 1.3e-07 31.8 6.4 1.8e-07 31.2 6.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) DUF5524 PF17662.1 PIK54386.1 - 0.015 14.7 5.2 0.016 14.6 5.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5524) Gon7 PF08738.10 PIK54386.1 - 0.16 12.1 6.3 0.55 10.3 6.3 1.9 1 1 0 1 1 1 0 Gon7 family Vfa1 PF08432.10 PIK54386.1 - 0.27 11.5 7.9 0.32 11.3 7.9 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 PIK54386.1 - 2.1 6.3 13.8 2.7 6.0 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 PIK54386.1 - 2.7 6.7 4.1 2.9 6.6 4.1 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 PIK54386.1 - 2.8 6.7 4.3 2.8 6.6 4.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2187 PF09953.9 PIK54387.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) Glycos_transf_2 PF00535.26 PIK54388.1 - 6e-32 110.8 0.0 8.8e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK54388.1 - 3.4e-19 69.4 0.4 5.2e-19 68.8 0.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 PIK54388.1 - 0.00022 20.8 0.0 0.00031 20.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 PIK54388.1 - 0.0015 18.1 0.1 0.0044 16.6 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Sulfotransfer_1 PF00685.27 PIK54389.1 - 8.8e-05 22.1 0.3 0.0059 16.1 0.1 2.6 2 1 1 3 3 3 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK54389.1 - 0.099 13.0 0.0 14 6.0 0.0 2.3 2 0 0 2 2 2 0 Sulfotransferase family HEAT_2 PF13646.6 PIK54390.1 - 7.2e-07 29.5 4.4 0.28 11.6 0.2 5.8 5 1 1 6 6 6 2 HEAT repeats HEAT PF02985.22 PIK54390.1 - 3.7e-06 26.7 15.1 0.64 10.4 0.0 7.3 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 PIK54390.1 - 0.0005 20.5 11.5 2.7 8.6 0.1 6.3 6 0 0 6 6 6 2 HEAT-like repeat DUF3437 PF11919.8 PIK54390.1 - 0.15 12.0 0.2 1.3 9.0 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) MMS19_C PF12460.8 PIK54390.1 - 2.6 7.1 6.7 17 4.4 0.1 4.8 6 1 0 6 6 6 0 RNAPII transcription regulator C-terminal TatD_DNase PF01026.21 PIK54392.1 - 6.4e-38 130.6 0.0 7.5e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 PIK54392.1 - 0.063 13.1 0.0 9.5 5.9 0.0 2.1 1 1 0 2 2 2 0 Amidohydrolase TatD_DNase PF01026.21 PIK54393.1 - 1.7e-06 27.6 0.0 2.1e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase zf-ribbon_3 PF13248.6 PIK54394.1 - 0.0091 15.4 1.6 0.0091 15.4 1.6 2.9 3 0 0 3 3 3 1 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 PIK54394.1 - 0.049 13.6 2.7 0.049 13.6 2.7 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zinc_ribbon_15 PF17032.5 PIK54394.1 - 0.11 13.3 8.8 0.12 13.2 1.7 2.3 2 0 0 2 2 2 0 zinc-ribbon family DZR PF12773.7 PIK54394.1 - 0.16 12.0 13.5 0.32 11.1 3.2 2.6 1 1 1 2 2 2 0 Double zinc ribbon Fer2_4 PF13510.6 PIK54394.1 - 0.49 10.5 5.2 3.8 7.6 0.3 2.8 2 1 1 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain zf-C3HC4_3 PF13920.6 PIK54394.1 - 0.56 10.1 15.6 14 5.7 0.2 3.0 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.10 PIK54394.1 - 0.64 10.2 14.5 0.96 9.6 0.9 3.6 2 1 1 3 3 3 0 Zinc ribbon domain Zn_ribbon_17 PF17120.5 PIK54394.1 - 0.67 9.6 9.6 2.6 7.7 0.6 2.8 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type TackOD1 PF18551.1 PIK54394.1 - 0.86 9.2 11.9 8.5 6.0 11.8 2.2 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 FdhE PF04216.12 PIK54394.1 - 2.6 7.9 10.9 9.4 6.0 10.9 1.9 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-RING_4 PF14570.6 PIK54394.1 - 5.1 7.0 15.8 3.1 7.7 2.7 3.4 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 PIK54394.1 - 7.8 6.4 7.0 23 4.9 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Glyco_transf_64 PF09258.10 PIK54395.1 - 2.6e-07 30.2 0.2 3.4e-07 29.8 0.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 PIK54396.1 - 1.4e-34 119.7 0.0 1.6e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Exostosin family Pribosyltran PF00156.27 PIK54397.1 - 3.5e-11 42.9 0.0 5.5e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyltran_N PF13793.6 PIK54397.1 - 3.6e-06 26.9 0.0 1.2e-05 25.3 0.0 1.9 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 PIK54397.1 - 0.00055 20.0 0.0 0.00092 19.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain UPRTase PF14681.6 PIK54397.1 - 0.014 14.9 0.0 0.03 13.8 0.0 1.5 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 PIK54397.1 - 0.069 12.6 0.0 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosyl transferase ADK PF00406.22 PIK54398.1 - 8.3e-58 194.8 0.0 9.6e-58 194.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 PIK54398.1 - 2.6e-26 92.7 0.4 1.4e-25 90.3 0.0 1.9 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 PIK54398.1 - 1.2e-15 57.2 0.0 4.2e-15 55.4 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.6 PIK54398.1 - 2.4e-05 24.6 0.0 4.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK54398.1 - 0.0047 17.5 0.0 0.0096 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 PIK54398.1 - 0.059 13.1 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase IF-2B PF01008.17 PIK54399.1 - 1.7e-71 240.8 0.2 2.9e-71 240.0 0.2 1.4 1 0 0 1 1 1 1 Initiation factor 2 subunit family HypA PF01155.19 PIK54400.1 - 0.15 12.1 3.5 0.24 11.5 3.2 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RecR PF02132.15 PIK54400.1 - 0.23 11.0 7.0 0.11 12.1 2.2 2.3 2 0 0 2 2 2 0 RecR protein DUF35_N PF12172.8 PIK54400.1 - 1.4 8.8 11.4 7.4 6.6 0.7 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) MTHFR_C PF12225.8 PIK54400.1 - 4 7.2 11.6 5.2e+02 0.4 11.6 2.7 1 1 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal Far-17a_AIG1 PF04750.14 PIK54401.1 - 3.4e-23 82.0 8.2 1.1e-16 60.7 5.0 2.2 2 0 0 2 2 2 2 FAR-17a/AIG1-like protein RVT_1 PF00078.27 PIK54402.1 - 1.7e-18 67.0 0.0 2.6e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4722 PF15849.5 PIK54402.1 - 0.049 13.3 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) RVP PF00077.20 PIK54402.1 - 0.13 12.6 0.0 0.43 10.9 0.0 1.9 2 0 0 2 2 2 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK54402.1 - 0.14 12.8 0.0 0.29 11.8 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 PIK54402.1 - 0.19 12.3 0.0 0.38 11.3 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease CCDC144C PF14915.6 PIK54403.1 - 0.00034 19.8 28.1 0.00034 19.8 28.1 3.3 1 1 2 3 3 3 1 CCDC144C protein coiled-coil region Fez1 PF06818.15 PIK54403.1 - 0.39 11.1 69.7 0.097 13.1 24.3 4.0 1 1 2 3 3 3 0 Fez1 BRCA-2_OB3 PF09104.10 PIK54403.1 - 1.4 8.6 10.4 0.031 13.9 2.1 2.7 3 1 0 3 3 3 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 HrpB7 PF09486.10 PIK54403.1 - 3.3 8.1 35.1 0.25 11.7 10.4 3.2 1 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 PIK54403.1 - 6.7 5.5 70.6 2.2 7.1 21.6 3.6 1 1 2 3 3 3 0 Spc7 kinetochore protein RT_RNaseH_2 PF17919.1 PIK54404.1 - 3.6e-24 84.7 0.1 6e-24 84.0 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK54404.1 - 3.5e-21 75.7 0.0 6.1e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK54404.1 - 6.1e-12 45.8 0.0 1.2e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pico_P2B PF01552.17 PIK54404.1 - 0.0082 16.3 0.9 0.019 15.1 0.0 2.0 2 0 0 2 2 2 1 Picornavirus 2B protein 7tm_1 PF00001.21 PIK54405.1 - 3.9e-19 69.0 9.6 5.9e-19 68.4 9.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK54405.1 - 0.0086 15.4 4.8 0.013 14.8 4.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Lipoprotein_21 PF14041.6 PIK54405.1 - 0.04 14.0 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 LppP/LprE lipoprotein GWT1 PF06423.12 PIK54405.1 - 0.11 12.7 4.3 0.057 13.6 1.7 1.7 1 1 1 2 2 2 0 GWT1 Ig_3 PF13927.6 PIK54406.1 - 9e-11 42.2 4.6 0.00021 21.9 0.0 4.8 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK54406.1 - 1.9e-10 40.9 0.3 6.4e-06 26.3 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.16 PIK54406.1 - 3e-06 27.2 0.1 0.058 13.5 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain Izumo-Ig PF16706.5 PIK54406.1 - 6.5e-05 22.9 0.0 0.0013 18.8 0.0 2.6 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 PIK54406.1 - 0.00018 21.7 3.2 2.2 8.7 0.0 4.5 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK54406.1 - 0.0031 17.6 1.8 2 8.6 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK54406.1 - 0.0038 17.0 2.4 0.69 9.7 0.2 2.9 2 1 0 2 2 2 2 Adenovirus E3 region protein CR1 C2-set_2 PF08205.12 PIK54406.1 - 0.028 14.5 0.1 0.58 10.3 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain RVT_1 PF00078.27 PIK54407.1 - 4.6e-27 95.0 0.0 5.3e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 PIK54408.1 - 3.4e-06 26.2 5.6 5.2e-05 22.3 5.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Aldedh PF00171.22 PIK54409.1 - 1.2e-151 505.4 0.0 1.4e-151 505.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 PIK54409.1 - 0.029 13.8 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) RVT_1 PF00078.27 PIK54411.1 - 2.5e-42 144.9 1.0 2.5e-42 144.9 1.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) MIEAP PF16026.5 PIK54411.1 - 0.057 13.6 1.0 0.43 10.8 1.4 2.2 2 0 0 2 2 2 0 Mitochondria-eating protein MIF PF01187.18 PIK54413.1 - 0.0066 16.7 0.0 0.0076 16.5 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) MIF PF01187.18 PIK54414.1 - 8.5e-11 42.2 0.0 9.8e-11 42.0 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 PIK54414.1 - 0.049 13.6 0.0 1 9.3 0.0 2.3 2 1 0 2 2 2 0 Tautomerase enzyme Rotavirus_VP7 PF05868.11 PIK54416.1 - 0.016 14.6 0.3 0.026 13.9 0.3 1.4 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 Aldedh PF00171.22 PIK54417.1 - 5.1e-24 84.6 0.0 5.6e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Syntaxin-6_N PF09177.11 PIK54417.1 - 0.093 13.3 0.3 0.13 12.9 0.3 1.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Aldedh PF00171.22 PIK54418.1 - 2.3e-48 164.9 0.8 2.3e-39 135.2 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 PIK54418.1 - 0.017 14.6 0.0 1.7 8.0 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1487) DUF1213 PF06740.12 PIK54420.1 - 9.2 6.9 7.7 7.8 7.2 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1213) EssA PF10661.9 PIK54420.1 - 9.3 6.1 10.1 0.2 11.5 0.8 2.5 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA RRM_1 PF00076.22 PIK54422.1 - 7.5e-27 93.0 0.1 1.6e-16 59.9 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK54422.1 - 1.5e-11 44.3 0.1 4.4e-05 23.5 0.0 2.4 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK54422.1 - 0.0037 17.3 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM PF05172.13 PIK54422.1 - 0.019 14.9 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 PIK54422.1 - 0.12 12.3 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 PIK54423.1 - 4.1e-14 52.1 0.0 1e-12 47.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK54423.1 - 0.0007 19.7 0.0 0.98 9.6 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif Laminin_G_1 PF00054.23 PIK54423.1 - 0.0053 17.0 0.0 0.057 13.6 0.0 2.0 2 0 0 2 2 2 1 Laminin G domain HYR PF02494.16 PIK54425.1 - 8.1e-61 202.3 15.5 1.5e-20 73.3 0.4 4.8 5 0 0 5 5 5 4 HYR domain PA_decarbox PF05870.11 PIK54425.1 - 0.037 13.6 0.1 6.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Phenolic acid decarboxylase (PAD) SIP PF04954.13 PIK54426.1 - 0.14 12.6 0.1 21 5.6 0.0 2.3 2 0 0 2 2 2 0 Siderophore-interacting protein Mito_fiss_reg PF05308.11 PIK54426.1 - 0.24 11.4 7.7 0.54 10.3 7.7 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator SAM_1 PF00536.30 PIK54427.1 - 0.00073 19.9 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-HC5HC2H PF13771.6 PIK54427.1 - 0.53 10.6 3.9 2.4 8.5 3.9 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C2H2 PF00096.26 PIK54427.1 - 1.3 9.7 10.0 6.9 7.3 0.4 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ceramidase PF05875.12 PIK54428.1 - 1.3e-14 54.3 2.6 1.5e-14 54.1 2.6 1.0 1 0 0 1 1 1 1 Ceramidase 7TM-7TMR_HD PF07698.11 PIK54428.1 - 0.031 14.1 3.6 0.036 13.8 3.6 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Ig_3 PF13927.6 PIK54429.1 - 1.1e-17 64.3 2.6 2.9e-05 24.6 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK54429.1 - 2.1e-17 63.0 0.8 6e-07 29.4 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK54429.1 - 1.8e-16 60.2 1.8 5.9e-06 26.5 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK54429.1 - 1.1e-13 51.1 1.7 1.2e-05 25.4 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK54429.1 - 9.9e-10 38.4 0.4 2.4e-06 27.5 0.2 4.0 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK54429.1 - 3.2e-09 36.9 0.8 2.7e-07 30.7 0.1 3.4 3 1 1 4 4 4 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK54430.1 - 5.6e-16 58.9 4.5 9.2e-06 26.2 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK54430.1 - 3.8e-15 56.0 3.4 1.9e-06 28.1 0.2 3.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK54430.1 - 4.6e-13 49.3 0.5 2.5e-09 37.3 0.0 4.3 4 0 0 4 4 4 1 Immunoglobulin V-set domain ig PF00047.25 PIK54430.1 - 1.2e-11 44.6 0.4 1.9e-08 34.4 0.0 4.0 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK54430.1 - 5.8e-08 32.7 0.4 0.0047 17.0 0.0 4.3 3 1 0 3 3 3 2 Immunoglobulin I-set domain Myc_target_1 PF15179.6 PIK54430.1 - 6e-05 23.0 0.3 0.00014 21.8 0.3 1.7 1 0 0 1 1 1 1 Myc target protein 1 C2-set_2 PF08205.12 PIK54430.1 - 0.00015 21.8 1.0 0.00083 19.4 0.1 2.8 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain DUF2613 PF11021.8 PIK54430.1 - 0.00056 20.0 1.6 0.095 12.8 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2613) Adeno_E3_CR2 PF02439.15 PIK54430.1 - 0.013 15.2 3.5 0.034 13.9 3.5 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ig_6 PF18452.1 PIK54430.1 - 0.059 12.9 0.9 0.2 11.3 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin domain TRP PF06011.12 PIK54430.1 - 0.094 11.4 0.1 0.14 10.8 0.1 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel BORCS8 PF10167.9 PIK54431.1 - 4.8e-39 132.8 0.7 6.2e-39 132.4 0.7 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 T3SS_ATPase_C PF18269.1 PIK54431.1 - 0.065 13.1 0.5 2.9 7.8 0.0 2.8 2 1 1 3 3 3 0 T3SS EscN ATPase C-terminal domain TIR_2 PF13676.6 PIK54432.1 - 1.1e-29 103.5 0.1 4.2e-22 79.0 0.0 2.7 3 0 0 3 3 3 2 TIR domain Fez1 PF06818.15 PIK54432.1 - 0.016 15.6 2.9 0.016 15.6 2.9 2.1 2 0 0 2 2 2 0 Fez1 HAUS-augmin3 PF14932.6 PIK54432.1 - 0.085 12.4 5.8 0.15 11.6 5.8 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 PIK54432.1 - 0.35 11.4 12.0 0.91 10.1 12.0 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region HemX PF04375.14 PIK54432.1 - 0.37 10.0 5.4 0.62 9.3 5.4 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2968 PF11180.8 PIK54432.1 - 0.47 10.1 6.1 0.86 9.2 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) ATG16 PF08614.11 PIK54432.1 - 1.2 9.3 15.3 0.098 12.9 9.4 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF16 PF01519.16 PIK54432.1 - 3 8.4 16.6 0.17 12.3 9.4 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4446 PF14584.6 PIK54432.1 - 3.1 7.8 11.0 0.48 10.4 4.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) DUF3552 PF12072.8 PIK54432.1 - 3.8 6.9 14.4 0.66 9.4 10.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) EzrA PF06160.12 PIK54432.1 - 4.2 5.4 17.9 0.67 8.1 8.6 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA GAS PF13851.6 PIK54432.1 - 4.9 6.4 16.1 0.11 11.8 8.1 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 PIK54432.1 - 8.2 5.2 16.7 1.3 7.8 12.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Blo-t-5 PF11642.8 PIK54433.1 - 0.065 13.2 2.8 0.14 12.1 2.8 1.5 1 0 0 1 1 1 0 Mite allergen Blo t 5 SlyX PF04102.12 PIK54434.1 - 0.0012 19.4 2.6 0.0012 19.4 2.6 2.7 3 1 1 4 4 3 1 SlyX Spc7 PF08317.11 PIK54434.1 - 0.0033 16.4 4.4 0.0058 15.6 4.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF16 PF01519.16 PIK54434.1 - 0.0037 17.7 7.0 0.0081 16.6 6.1 2.2 2 1 0 2 2 1 1 Protein of unknown function DUF16 DUF4164 PF13747.6 PIK54434.1 - 0.0049 17.1 3.3 0.014 15.7 3.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) BLOC1_2 PF10046.9 PIK54434.1 - 0.0073 16.6 0.9 0.0073 16.6 0.9 3.2 3 1 0 3 3 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.8 PIK54434.1 - 0.02 14.9 3.4 0.02 14.9 3.4 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 PIK54434.1 - 0.021 15.0 6.4 0.025 14.7 4.7 1.9 2 0 0 2 2 2 0 Tropomyosin like Laminin_II PF06009.12 PIK54434.1 - 0.021 14.8 3.5 0.035 14.1 2.2 1.9 2 0 0 2 2 2 0 Laminin Domain II GP41 PF00517.17 PIK54434.1 - 0.065 13.1 0.7 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Retroviral envelope protein MscS_porin PF12795.7 PIK54434.1 - 0.073 12.6 1.7 0.14 11.7 1.7 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF1664 PF07889.12 PIK54434.1 - 0.075 13.1 6.0 0.031 14.3 2.3 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4559 PF15112.6 PIK54434.1 - 0.086 12.5 4.8 0.14 11.8 4.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) DUF948 PF06103.11 PIK54434.1 - 0.12 12.6 7.6 0.12 12.6 3.7 2.6 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Flagellin_C PF00700.21 PIK54434.1 - 0.12 12.7 0.7 0.39 11.1 0.7 1.9 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region ATG16 PF08614.11 PIK54434.1 - 0.14 12.4 6.1 0.22 11.7 6.0 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Pec_lyase_N PF04431.13 PIK54434.1 - 0.14 12.4 0.0 6.4 7.1 0.0 2.6 2 0 0 2 2 2 0 Pectate lyase, N terminus Med9 PF07544.13 PIK54434.1 - 0.24 11.5 2.7 6.7 6.9 0.1 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 NPV_P10 PF05531.12 PIK54434.1 - 0.32 11.5 4.3 0.73 10.3 3.4 2.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 PIK54434.1 - 0.61 10.3 4.8 0.55 10.5 2.1 2.5 2 1 0 2 2 2 0 Haemolysin XhlA Fib_alpha PF08702.10 PIK54434.1 - 0.65 10.2 4.8 0.83 9.8 1.6 2.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 PIK54434.1 - 6.1 7.3 7.9 3.4 8.1 0.7 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TIR_2 PF13676.6 PIK54435.1 - 1.1e-45 155.0 0.0 4.3e-22 78.9 0.0 2.4 2 0 0 2 2 2 2 TIR domain TIR PF01582.20 PIK54435.1 - 0.00071 19.4 0.0 0.94 9.3 0.0 2.6 3 0 0 3 3 3 2 TIR domain Death PF00531.22 PIK54435.1 - 0.0019 18.3 0.1 0.0041 17.3 0.1 1.6 1 0 0 1 1 1 1 Death domain SEFIR PF08357.11 PIK54435.1 - 0.051 13.9 0.0 15 5.9 0.0 2.5 2 0 0 2 2 2 0 SEFIR domain MCPVI PF02993.14 PIK54435.1 - 0.14 12.0 10.9 0.34 10.7 10.9 1.6 1 0 0 1 1 1 0 Minor capsid protein VI Med16 PF11635.8 PIK54436.1 - 0.05 11.5 0.1 0.064 11.2 0.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 16 zf-C2H2_11 PF16622.5 PIK54436.1 - 0.086 12.6 0.1 0.3 10.9 0.1 1.9 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-CCHC_5 PF14787.6 PIK54436.1 - 9.6 6.0 14.3 3.9 7.3 4.4 3.7 3 1 0 3 3 3 0 GAG-polyprotein viral zinc-finger Death PF00531.22 PIK54437.1 - 1.4e-11 44.4 0.0 4.1e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 Death domain Laminin_II PF06009.12 PIK54437.1 - 0.00029 20.9 5.4 0.00051 20.1 5.4 1.4 1 0 0 1 1 1 1 Laminin Domain II SlyX PF04102.12 PIK54437.1 - 0.00054 20.5 6.3 0.0024 18.5 4.8 2.4 1 1 1 2 2 2 1 SlyX Spc7 PF08317.11 PIK54437.1 - 0.0013 17.7 6.6 0.0019 17.2 6.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BLOC1_2 PF10046.9 PIK54437.1 - 0.0014 18.9 6.3 0.0048 17.2 1.0 2.4 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 PIK54437.1 - 0.0027 18.2 9.9 0.023 15.2 10.0 2.3 1 1 0 1 1 1 1 Protein of unknown function DUF16 Laminin_I PF06008.14 PIK54437.1 - 0.0031 17.2 3.3 0.005 16.6 3.3 1.3 1 0 0 1 1 1 1 Laminin Domain I TMF_DNA_bd PF12329.8 PIK54437.1 - 0.0044 17.0 3.4 0.0079 16.2 2.7 1.8 1 1 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DUF4164 PF13747.6 PIK54437.1 - 0.0056 16.9 4.5 0.012 15.9 4.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) CNOT1_HEAT PF16418.5 PIK54437.1 - 0.018 15.1 0.1 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF1664 PF07889.12 PIK54437.1 - 0.023 14.7 6.8 0.052 13.6 6.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 PIK54437.1 - 0.03 14.6 4.7 0.044 14.0 4.7 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) HOOK PF05622.12 PIK54437.1 - 0.031 12.5 6.9 0.038 12.2 6.9 1.1 1 0 0 1 1 1 0 HOOK protein MscS_porin PF12795.7 PIK54437.1 - 0.048 13.2 2.2 0.12 11.9 2.1 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Flagellin_C PF00700.21 PIK54437.1 - 0.056 13.8 2.2 0.35 11.2 0.4 2.3 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region Tropomyosin_1 PF12718.7 PIK54437.1 - 0.069 13.3 12.0 0.04 14.1 6.2 2.1 1 1 1 2 2 2 0 Tropomyosin like Curto_V2 PF07325.11 PIK54437.1 - 0.1 12.5 0.8 0.18 11.7 0.5 1.5 1 1 0 1 1 1 0 Curtovirus V2 protein HEAT_2 PF13646.6 PIK54437.1 - 0.11 12.9 0.1 11 6.5 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats Fib_alpha PF08702.10 PIK54437.1 - 0.12 12.5 3.9 0.28 11.4 3.4 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ABC_tran_CTD PF16326.5 PIK54437.1 - 0.12 12.6 2.5 0.33 11.2 2.5 1.8 1 0 0 1 1 1 0 ABC transporter C-terminal domain Med9 PF07544.13 PIK54437.1 - 0.14 12.3 3.0 4.6 7.4 0.1 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 LMBR1 PF04791.16 PIK54437.1 - 0.14 11.0 0.7 0.18 10.7 0.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ING PF12998.7 PIK54437.1 - 0.17 12.5 2.2 9 7.0 0.3 2.5 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding TMPIT PF07851.13 PIK54437.1 - 0.18 11.0 0.2 0.25 10.5 0.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF948 PF06103.11 PIK54437.1 - 0.26 11.6 9.2 0.13 12.6 4.6 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 PIK54437.1 - 0.43 11.1 9.6 7.2 7.2 8.7 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 PIK54437.1 - 0.7 10.1 9.5 0.57 10.4 2.6 2.7 1 1 1 2 2 2 0 Haemolysin XhlA SOAR PF16533.5 PIK54437.1 - 0.8 9.7 4.3 0.9 9.5 0.3 2.6 1 1 1 2 2 2 0 STIM1 Orai1-activating region COG2 PF06148.11 PIK54437.1 - 1.3 9.1 5.6 2.5 8.2 5.6 1.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2730 PF10805.8 PIK54437.1 - 1.4 9.0 4.8 2.9 8.1 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.11 PIK54437.1 - 1.6 9.2 10.5 2 8.8 0.8 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4559 PF15112.6 PIK54437.1 - 2.2 7.9 7.4 8.7 5.9 7.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) TIR_2 PF13676.6 PIK54438.1 - 5.8e-45 152.7 0.0 3.5e-21 76.0 0.0 2.5 2 0 0 2 2 2 2 TIR domain Death PF00531.22 PIK54438.1 - 1.6e-07 31.4 0.1 3.3e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Death domain TIR PF01582.20 PIK54438.1 - 0.0012 18.6 0.1 0.98 9.2 0.0 2.6 3 0 0 3 3 3 2 TIR domain SEFIR PF08357.11 PIK54438.1 - 0.0028 17.9 0.0 1.3 9.3 0.0 2.6 2 0 0 2 2 2 2 SEFIR domain DUF1863 PF08937.11 PIK54438.1 - 0.16 12.3 2.6 30 4.9 0.2 3.9 3 2 0 3 3 3 0 MTH538 TIR-like domain (DUF1863) MCPVI PF02993.14 PIK54438.1 - 0.74 9.6 10.8 1.7 8.4 10.8 1.5 1 0 0 1 1 1 0 Minor capsid protein VI HYR PF02494.16 PIK54439.1 - 0 1088.1 174.2 2.1e-21 76.0 1.0 21.1 21 0 0 21 21 21 21 HYR domain DUF5011 PF16403.5 PIK54439.1 - 1.4e-18 66.7 31.2 5.4 7.2 0.3 17.0 19 0 0 19 19 19 8 Domain of unknown function (DUF5011) EGF PF00008.27 PIK54439.1 - 0.00025 21.3 5.3 0.00067 19.9 5.3 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 PIK54439.1 - 1.6 9.2 6.7 3.9 7.9 6.7 1.7 1 0 0 1 1 1 0 EGF-like domain HYR PF02494.16 PIK54440.1 - 4.8e-111 363.3 53.3 8.3e-20 70.9 4.3 6.1 6 0 0 6 6 6 6 HYR domain fn3 PF00041.21 PIK54440.1 - 1.9e-06 28.1 15.7 5.7 7.3 0.1 5.7 5 0 0 5 5 5 5 Fibronectin type III domain CzcE PF16986.5 PIK54440.1 - 0.89 9.9 3.5 3.5e+02 1.6 0.0 4.9 6 0 0 6 6 6 0 Heavy-metal resistance protein CzcE MIP PF00230.20 PIK54441.1 - 1.9e-55 188.1 9.0 2.3e-55 187.8 9.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein nlz1 PF12402.8 PIK54441.1 - 0.19 12.2 0.1 0.19 12.2 0.1 1.9 2 0 0 2 2 2 0 NocA-like zinc-finger protein 1 Rab3-GTPase_cat PF13890.6 PIK54442.1 - 5.1e-68 227.8 0.8 1.2e-67 226.6 0.8 1.7 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Pkinase PF00069.25 PIK54444.1 - 2.4e-62 210.7 0.5 3.6e-62 210.1 0.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54444.1 - 8.9e-34 116.9 0.1 1.3e-33 116.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK54444.1 - 1.7e-07 30.9 0.0 7.1e-07 28.8 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK54444.1 - 4.3e-05 22.5 1.1 6.7e-05 21.8 1.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK54444.1 - 0.00076 19.5 0.0 0.087 12.7 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK54444.1 - 0.0033 17.1 0.1 0.0061 16.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 PIK54444.1 - 0.0042 16.5 0.4 0.0097 15.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4892 PF16234.5 PIK54444.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4892) FTA2 PF13095.6 PIK54444.1 - 0.02 14.5 0.4 0.47 10.0 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 bZIP_1 PF00170.21 PIK54445.1 - 3.7e-14 52.6 15.2 8e-14 51.5 15.2 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK54445.1 - 1.2e-10 41.3 8.6 1.2e-10 41.3 8.6 2.2 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.17 PIK54445.1 - 8.4e-05 23.0 13.0 0.00023 21.6 13.0 1.8 1 1 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 PIK54445.1 - 0.0054 17.2 1.6 0.016 15.6 1.6 1.7 1 0 0 1 1 1 1 Cell division protein ZapB HI0933_like PF03486.14 PIK54445.1 - 0.16 10.6 2.9 0.25 10.0 2.9 1.2 1 0 0 1 1 1 0 HI0933-like protein RNA_polI_A14 PF08203.11 PIK54445.1 - 0.19 12.5 1.9 0.49 11.1 1.9 1.8 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 HTH_Tnp_IS630 PF01710.16 PIK54445.1 - 0.25 11.4 3.5 0.45 10.6 3.5 1.3 1 0 0 1 1 1 0 Transposase HAUS-augmin3 PF14932.6 PIK54445.1 - 0.26 10.8 9.2 0.41 10.2 9.0 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 HALZ PF02183.18 PIK54445.1 - 0.4 10.9 6.6 1.5 9.1 6.6 2.0 1 1 1 2 2 2 0 Homeobox associated leucine zipper KIAA1430 PF13879.6 PIK54445.1 - 1.5 9.7 10.2 4.8 8.0 10.2 1.9 1 1 0 1 1 1 0 KIAA1430 homologue M PF02370.16 PIK54445.1 - 1.5 9.6 5.9 8.2 7.4 5.9 2.3 1 0 0 1 1 1 0 M protein repeat APG6_N PF17675.1 PIK54445.1 - 1.7 9.2 11.2 1.3 9.6 9.3 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region SOGA PF11365.8 PIK54445.1 - 2.5 9.3 9.8 4.5 8.5 9.1 1.8 1 1 0 1 1 1 0 Protein SOGA DivIC PF04977.15 PIK54445.1 - 4.5 7.1 6.7 4.8 7.0 5.4 1.8 1 1 0 1 1 1 0 Septum formation initiator ADH_N PF08240.12 PIK54446.1 - 1.1e-19 70.3 3.0 1.9e-19 69.6 3.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK54446.1 - 0.00015 21.8 0.0 0.00033 20.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK54446.1 - 0.0035 16.9 0.0 0.0059 16.1 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NADH_4Fe-4S PF10589.9 PIK54446.1 - 0.027 14.6 3.1 0.07 13.2 3.1 1.8 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region ThiF PF00899.21 PIK54446.1 - 0.087 12.2 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 ThiF family ELFV_dehydrog PF00208.21 PIK54446.1 - 0.096 12.4 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase IGFBP PF00219.18 PIK54446.1 - 0.65 10.7 8.4 0.37 11.5 4.7 2.5 2 0 0 2 2 2 0 Insulin-like growth factor binding protein PrsW-protease PF13367.6 PIK54447.1 - 0.011 15.2 0.3 0.012 15.0 0.3 1.1 1 0 0 1 1 1 0 PrsW family intramembrane metalloprotease IMS PF00817.20 PIK54448.1 - 6.1e-42 143.2 0.0 1.3e-41 142.1 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 PIK54448.1 - 3.9e-09 37.2 0.1 9.6e-09 36.0 0.1 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain HHH_5 PF14520.6 PIK54448.1 - 0.01 16.4 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Tmemb_18A PF09771.9 PIK54448.1 - 0.011 16.2 1.7 0.53 10.7 0.3 2.4 2 0 0 2 2 2 0 Transmembrane protein 188 DUF4332 PF14229.6 PIK54448.1 - 0.026 14.8 0.0 0.084 13.1 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Cdd1 PF11731.8 PIK54448.1 - 0.083 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Pathogenicity locus SLC12 PF03522.15 PIK54449.1 - 5.5e-140 467.2 1.5 1.8e-90 304.0 1.1 2.1 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease PF00324.21 PIK54449.1 - 3.9e-85 286.2 33.7 9.3e-44 149.8 9.3 2.1 1 1 1 2 2 2 2 Amino acid permease MaoC_dehydrat_N PF13452.6 PIK54450.1 - 4.9e-06 26.7 0.0 8.2e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 PIK54451.1 - 1.5e-20 73.0 0.0 1.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain ISK_Channel PF02060.15 PIK54451.1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Slow voltage-gated potassium channel SCP2 PF02036.17 PIK54452.1 - 4.7e-15 55.9 0.3 5.1e-15 55.8 0.3 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 PIK54452.1 - 3.9e-08 33.6 0.1 3.9e-08 33.6 0.1 1.0 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal 7tm_1 PF00001.21 PIK54453.1 - 3.8e-18 65.8 1.3 3.8e-18 65.8 1.3 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Death PF00531.22 PIK54454.1 - 2.2e-14 53.4 2.7 2.9e-14 53.0 2.7 1.2 1 0 0 1 1 1 1 Death domain Rootletin PF15035.6 PIK54454.1 - 0.016 15.3 5.4 0.021 14.8 5.4 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CARD_2 PF16739.5 PIK54454.1 - 0.061 13.3 1.6 0.094 12.7 1.0 1.6 1 1 1 2 2 2 0 Caspase recruitment domain RVT_1 PF00078.27 PIK54455.1 - 4.8e-10 39.3 0.0 6.3e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK54455.1 - 0.00029 20.8 0.0 0.00056 19.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK54456.1 - 1e-19 70.9 0.0 1.6e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK54456.1 - 0.00024 20.8 0.0 0.00053 19.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF4033 PF13225.6 PIK54456.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4033) ZU5 PF00791.20 PIK54457.1 - 3e-10 40.3 0.1 4.8e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK54457.1 - 1.9e-09 37.6 1.4 3e-09 36.9 1.4 1.3 1 0 0 1 1 1 1 Death domain DUF2703 PF10865.8 PIK54457.1 - 0.069 13.3 0.2 3.4 7.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) Mononeg_RNA_pol PF00946.19 PIK54459.1 - 0.018 12.7 0.6 1.5 6.3 0.0 2.1 2 0 0 2 2 2 0 Mononegavirales RNA dependent RNA polymerase IDO PF01231.18 PIK54459.1 - 0.076 11.8 0.2 0.29 9.9 0.1 1.8 2 0 0 2 2 2 0 Indoleamine 2,3-dioxygenase DHHC PF01529.20 PIK54460.1 - 1.6e-14 54.1 1.8 2.2e-14 53.7 1.8 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF1282 PF06930.12 PIK54460.1 - 0.0068 16.2 0.2 0.0094 15.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) MtrE PF04206.12 PIK54460.1 - 0.02 14.2 0.1 0.025 13.9 0.1 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E DUF4052 PF13261.6 PIK54460.1 - 0.025 14.4 2.6 0.025 14.4 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4052) Pox_G9-A16 PF03003.16 PIK54460.1 - 0.067 12.9 2.1 4.5 7.0 0.1 2.7 2 1 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 DUF1980 PF09323.10 PIK54460.1 - 0.13 12.2 0.2 0.15 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) RVT_1 PF00078.27 PIK54462.1 - 0.0014 18.2 0.1 0.0066 16.0 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Troponin PF00992.20 PIK54463.1 - 1.2e-06 28.9 0.1 1.2e-06 28.9 0.1 2.4 2 1 0 2 2 2 1 Troponin CDC45 PF02724.14 PIK54463.1 - 6 5.0 16.2 5.8 5.1 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_10 PF00852.19 PIK54465.1 - 2.8e-50 170.5 5.2 5.2e-50 169.6 5.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK54465.1 - 9.3e-08 32.5 0.2 9.3e-08 32.5 0.2 1.9 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal S_locus_glycop PF00954.20 PIK54465.1 - 0.0064 17.0 2.5 0.047 14.2 0.7 2.7 2 0 0 2 2 2 1 S-locus glycoprotein domain TPT PF03151.16 PIK54469.1 - 1.1e-22 80.8 20.4 1.3e-22 80.6 20.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 PIK54469.1 - 3.4e-05 24.0 30.2 0.0012 19.0 8.6 2.6 2 1 0 2 2 2 2 EamA-like transporter family JmjN PF02375.17 PIK54470.1 - 4.2e-18 65.0 0.8 9.1e-18 63.9 1.0 1.5 2 0 0 2 2 2 1 jmjN domain PLU-1 PF08429.11 PIK54471.1 - 3.1e-90 302.8 18.2 1.4e-89 300.6 14.4 3.4 3 1 0 3 3 3 2 PLU-1-like protein JmjC PF02373.22 PIK54471.1 - 2e-42 144.2 2.0 2e-42 144.2 2.0 2.7 4 0 0 4 4 4 1 JmjC domain, hydroxylase PHD PF00628.29 PIK54471.1 - 1.5e-20 72.8 49.3 6.7e-11 41.9 7.2 4.7 4 1 0 4 4 4 3 PHD-finger zf-C5HC2 PF02928.16 PIK54471.1 - 7.6e-18 64.6 16.2 7.6e-18 64.6 16.2 3.3 3 0 0 3 3 3 1 C5HC2 zinc finger ARID PF01388.21 PIK54471.1 - 1.5e-08 35.2 0.0 4.8e-08 33.6 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-CCHC_2 PF13696.6 PIK54471.1 - 0.011 15.5 5.9 0.12 12.2 0.4 2.9 2 0 0 2 2 2 0 Zinc knuckle Zip PF02535.22 PIK54471.1 - 1.1 8.4 5.9 2 7.6 5.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter EMC3_TMCO1 PF01956.16 PIK54475.1 - 9.9e-42 142.5 0.6 1.3e-41 142.2 0.6 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Minor_capsid_2 PF11114.8 PIK54475.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Minor capsid protein Pkinase PF00069.25 PIK54476.1 - 3.9e-50 170.7 0.1 4.7e-50 170.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54476.1 - 6.4e-18 65.0 0.0 9.5e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK54476.1 - 0.0025 17.8 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 PIK54476.1 - 0.037 13.4 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 PIK54476.1 - 0.04 13.3 0.1 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK54476.1 - 0.15 11.0 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain AdoHcyase PF05221.17 PIK54477.1 - 3e-118 394.3 0.0 3.5e-63 213.5 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 PIK54477.1 - 1.2e-77 259.5 2.0 1.7e-77 259.0 2.0 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 PIK54477.1 - 1e-07 31.5 1.0 1.2e-07 31.2 0.1 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 PIK54477.1 - 0.00032 20.3 0.0 0.00053 19.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 PIK54477.1 - 0.00035 19.9 0.8 0.0012 18.2 0.8 1.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 PIK54477.1 - 0.0096 16.3 0.3 0.023 15.1 0.3 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 PIK54477.1 - 0.017 15.2 0.2 0.057 13.5 0.2 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UPF0180 PF03698.13 PIK54477.1 - 0.045 13.9 0.0 1.1 9.5 0.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) TrkA_N PF02254.18 PIK54477.1 - 0.047 14.0 1.6 0.2 11.9 0.9 2.3 2 1 0 2 2 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 PIK54477.1 - 0.068 12.4 0.8 0.19 11.0 0.8 1.6 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Dehydrin PF00257.19 PIK54477.1 - 1.6 9.2 7.0 2.9 8.4 7.0 1.3 1 0 0 1 1 1 0 Dehydrin SR-25 PF10500.9 PIK54477.1 - 8.9 5.8 12.7 13 5.3 12.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nrf1_DNA-bind PF10491.9 PIK54478.1 - 3.3e-114 379.9 0.1 4.8e-114 379.3 0.1 1.2 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Ldh_1_C PF02866.18 PIK54478.1 - 0.046 13.6 1.5 0.19 11.6 1.4 2.2 1 1 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Tombus_movement PF05318.12 PIK54479.1 - 1.4 9.8 10.7 0.9 10.4 1.4 2.2 2 0 0 2 2 2 0 Tombusvirus movement protein DUF3402 PF11882.8 PIK54480.1 - 1.6e-105 353.9 11.9 2.4e-67 228.1 1.6 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 PIK54480.1 - 1.3e-11 44.2 0.0 2.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 N1221-like protein N1221 PF07923.13 PIK54481.1 - 4.1e-33 114.8 0.7 5.2e-33 114.5 0.7 1.1 1 0 0 1 1 1 1 N1221-like protein Vta1 PF04652.16 PIK54481.1 - 0.048 13.6 0.1 0.071 13.1 0.1 1.2 1 0 0 1 1 1 0 Vta1 like Pkinase PF00069.25 PIK54482.1 - 4e-69 232.9 0.0 4.7e-69 232.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54482.1 - 9.2e-28 97.2 0.0 1.2e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK54482.1 - 9.5e-05 21.5 0.0 0.00044 19.3 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK54482.1 - 0.015 15.3 0.0 0.033 14.1 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 PIK54482.1 - 0.02 14.2 0.0 0.21 10.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Kelch_1 PF01344.25 PIK54483.1 - 1.7e-41 139.5 8.2 2.3e-07 30.3 0.0 8.9 9 0 0 9 9 9 5 Kelch motif Kelch_6 PF13964.6 PIK54483.1 - 2.2e-27 94.4 5.0 0.004 17.4 0.0 8.1 5 4 4 9 9 9 7 Kelch motif Kelch_2 PF07646.15 PIK54483.1 - 6.4e-23 79.8 6.4 0.0026 17.7 0.0 7.8 8 0 0 8 8 8 5 Kelch motif Kelch_3 PF13415.6 PIK54483.1 - 7.7e-20 70.7 0.0 0.005 17.1 0.0 7.4 8 0 0 8 8 8 6 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK54483.1 - 4.5e-13 49.0 11.1 0.0023 17.9 0.0 8.0 6 2 3 9 9 9 3 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK54483.1 - 5.1e-13 48.7 0.0 0.0042 17.0 0.0 6.0 7 0 0 7 7 7 3 Kelch motif GDI PF00996.18 PIK54484.1 - 4.1e-185 615.4 2.8 6.4e-105 351.2 0.3 2.0 1 1 1 2 2 2 2 GDP dissociation inhibitor zf-H2C2_2 PF13465.6 PIK54485.1 - 1.8e-54 179.8 201.8 3.6e-08 33.5 1.1 23.3 24 0 0 24 24 24 16 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54485.1 - 8.5e-30 100.9 205.3 0.027 15.3 2.3 24.2 24 0 0 24 24 24 20 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK54485.1 - 1.3e-20 72.7 215.9 0.00063 20.1 2.3 23.5 24 0 0 24 24 24 17 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK54485.1 - 1.6e-11 44.2 158.7 0.011 16.0 1.3 22.3 22 1 1 23 23 23 13 Zinc-finger double-stranded RNA-binding GATA PF00320.27 PIK54485.1 - 0.0029 17.2 0.1 0.0029 17.2 0.1 8.1 8 1 0 8 8 8 1 GATA zinc finger zf-met PF12874.7 PIK54485.1 - 0.024 15.0 1.7 0.053 13.9 0.9 18.5 19 1 1 20 20 20 0 Zinc-finger of C2H2 type RNase_H_2 PF13482.6 PIK54485.1 - 1.1 9.2 6.4 26 4.7 0.0 4.4 4 1 1 5 5 5 0 RNase_H superfamily zf-H2C2_2 PF13465.6 PIK54486.1 - 2.8e-39 131.8 169.5 1.1e-08 35.1 0.9 19.9 19 1 1 20 20 20 16 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54486.1 - 4.8e-24 83.0 186.5 0.0042 17.8 2.2 20.6 21 0 0 21 21 21 15 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK54486.1 - 1e-13 50.9 195.8 0.0027 18.1 4.7 20.9 21 1 0 21 21 21 12 Zinc finger, C2H2 type Integrase_H2C2 PF17921.1 PIK54486.1 - 1.8e-13 50.4 0.8 1.8e-13 50.4 0.8 3.6 2 0 0 2 2 2 1 Integrase zinc binding domain zf-C2H2_jaz PF12171.8 PIK54486.1 - 4.4e-09 36.4 119.1 0.0075 16.5 0.6 18.1 18 0 0 18 18 18 7 Zinc-finger double-stranded RNA-binding zf-H2C2 PF09337.10 PIK54486.1 - 0.00085 19.5 0.1 0.00085 19.5 0.1 3.7 3 0 0 3 3 3 1 H2C2 zinc finger zf-C2H2_6 PF13912.6 PIK54486.1 - 0.0033 17.4 14.6 0.0045 17.0 2.9 19.3 20 0 0 20 20 20 5 C2H2-type zinc finger zf-C2HE PF16278.5 PIK54486.1 - 0.0041 17.5 0.5 0.0041 17.5 0.5 13.4 7 3 6 13 13 13 1 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 PIK54486.1 - 0.11 12.9 0.1 0.11 12.9 0.1 16.2 19 0 0 19 19 19 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK54486.1 - 0.35 11.6 81.6 1.9 9.3 0.6 10.5 6 1 3 11 11 11 0 zinc-ribbon family Matrilin_ccoil PF10393.9 PIK54487.1 - 1.8 8.5 7.1 9 6.2 0.3 4.4 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Hom_end_hint PF05203.16 PIK54487.1 - 2.6 7.9 6.5 17 5.3 2.6 2.3 2 0 0 2 2 2 0 Hom_end-associated Hint DUF812 PF05667.11 PIK54487.1 - 6.6 5.5 42.7 1.3 7.9 3.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF812) Exonuc_VII_L PF02601.15 PIK54487.1 - 8.7 5.8 34.9 3.2 7.2 1.0 3.1 2 1 1 3 3 3 0 Exonuclease VII, large subunit DUF1664 PF07889.12 PIK54487.1 - 9.6 6.3 29.5 0.25 11.4 6.8 5.0 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Sec7 PF01369.20 PIK54488.1 - 1.3e-66 223.7 1.4 2.4e-66 222.9 1.4 1.4 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 PIK54488.1 - 8.5e-46 155.4 0.5 2.6e-45 153.8 0.2 2.0 2 0 0 2 2 2 1 PH domain WASH_WAHD PF11945.8 PIK54489.1 - 9.2e-108 360.2 2.4 1.3e-107 359.7 2.4 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex DUF2357 PF09823.9 PIK54489.1 - 0.073 12.3 0.8 0.12 11.6 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) RP-C_C PF11800.8 PIK54489.1 - 0.16 12.1 0.5 0.34 11.0 0.5 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region KxDL PF10241.9 PIK54489.1 - 0.22 11.8 2.9 0.17 12.2 0.6 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein Tnp_P_element PF12017.8 PIK54492.1 - 3.9e-10 39.6 0.5 6.4e-10 38.8 0.5 1.4 1 0 0 1 1 1 1 Transposase protein THAP PF05485.12 PIK54492.1 - 1.3e-09 38.9 0.4 2.7e-09 37.8 0.4 1.6 1 0 0 1 1 1 1 THAP domain Mon2_C PF16206.5 PIK54493.1 - 9.1e-95 318.4 1.9 5.8e-94 315.8 1.9 2.2 1 1 0 1 1 1 1 C-terminal region of Mon2 protein DCB PF16213.5 PIK54493.1 - 3.4e-51 173.4 5.1 3.4e-51 173.4 5.1 3.2 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 PIK54493.1 - 1.6e-49 167.8 0.6 5.3e-49 166.2 0.1 2.3 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 PIK54493.1 - 2.1e-18 65.9 0.6 3e-16 59.0 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.22 PIK54493.1 - 0.021 15.1 0.5 36 5.0 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat Mon2_C PF16206.5 PIK54494.1 - 3.4e-16 58.6 0.1 3.4e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 C-terminal region of Mon2 protein DUF792 PF05632.11 PIK54494.1 - 0.063 13.1 0.0 0.92 9.4 0.0 2.0 1 1 1 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF792) Mon2_C PF16206.5 PIK54495.1 - 8.2e-79 265.7 1.0 1e-78 265.4 1.0 1.1 1 0 0 1 1 1 1 C-terminal region of Mon2 protein YaiA PF16362.5 PIK54495.1 - 0.17 12.0 0.0 0.44 10.7 0.0 1.6 1 0 0 1 1 1 0 YaiA protein Ras PF00071.22 PIK54496.1 - 4.7e-54 182.3 0.0 5.6e-54 182.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK54496.1 - 1.1e-20 74.0 0.0 1.7e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK54496.1 - 2.3e-06 27.2 0.0 4e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF4256 PF14066.6 PIK54496.1 - 0.022 14.4 0.2 0.032 13.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4256) GTP_EFTU PF00009.27 PIK54496.1 - 0.039 13.5 0.2 0.17 11.4 0.0 2.0 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK54496.1 - 0.048 13.1 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK54497.1 - 6.3e-58 194.9 0.0 7.4e-58 194.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK54497.1 - 2e-23 82.9 0.0 2.7e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK54497.1 - 2.8e-09 36.7 0.0 4.5e-09 36.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK54497.1 - 0.0004 20.0 0.0 0.0008 19.0 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK54497.1 - 0.044 13.2 0.0 0.085 12.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK54497.1 - 0.07 12.5 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Mito_fiss_Elm1 PF06258.11 PIK54497.1 - 0.08 12.1 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission ELM1 DUF1759 PF03564.15 PIK54498.1 - 0.023 14.7 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Retrotrans_gag PF03732.17 PIK54498.1 - 0.039 14.2 0.0 0.093 13.0 0.0 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein RVT_1 PF00078.27 PIK54499.1 - 4e-24 85.4 0.0 5.4e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK54499.1 - 0.025 14.7 0.1 0.066 13.3 0.0 1.6 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) rve PF00665.26 PIK54500.1 - 7.9e-16 58.3 0.0 9.3e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain Sugar_tr PF00083.24 PIK54502.1 - 8.2e-23 81.0 4.0 1.1e-22 80.6 4.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK54502.1 - 5.4e-07 28.9 20.3 8.6e-06 24.9 17.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NEMP PF10225.9 PIK54502.1 - 0.13 11.9 4.1 0.16 11.6 1.4 2.1 2 0 0 2 2 2 0 NEMP family CABIT PF12736.7 PIK54503.1 - 0.00063 19.1 0.7 0.032 13.5 0.7 2.7 1 1 0 1 1 1 1 Cell-cycle sustaining, positive selection, SAM_1 PF00536.30 PIK54503.1 - 0.034 14.6 0.1 0.058 13.8 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK54504.1 - 8.3e-09 35.8 0.1 1.5e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK54504.1 - 6.2e-06 26.2 0.3 1e-05 25.6 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) GIT_CC PF16559.5 PIK54505.1 - 8.5e-05 22.3 4.5 0.047 13.5 1.7 3.3 2 1 1 3 3 3 2 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 PIK54505.1 - 8.8e-05 22.9 2.7 0.00056 20.3 0.2 2.4 2 0 0 2 2 2 1 Cell division protein ZapB SAM_1 PF00536.30 PIK54505.1 - 0.00012 22.4 0.0 0.00032 21.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CABIT PF12736.7 PIK54505.1 - 0.00073 18.9 0.1 2.8 7.1 0.1 3.3 1 1 1 2 2 2 2 Cell-cycle sustaining, positive selection, Leu_zip PF15294.6 PIK54505.1 - 0.0013 18.3 0.5 0.0013 18.3 0.5 1.5 2 0 0 2 2 2 1 Leucine zipper bZIP_1 PF00170.21 PIK54505.1 - 0.0066 16.5 1.1 0.0066 16.5 1.1 2.0 2 0 0 2 2 2 1 bZIP transcription factor TSC22 PF01166.18 PIK54505.1 - 0.0075 16.6 2.6 1.4 9.2 0.1 2.6 2 0 0 2 2 2 1 TSC-22/dip/bun family KASH_CCD PF14662.6 PIK54505.1 - 0.0094 15.8 3.2 0.044 13.6 0.5 2.2 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH NRBF2 PF08961.10 PIK54505.1 - 0.0094 15.6 1.6 1.1 8.9 0.7 2.4 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator ADIP PF11559.8 PIK54505.1 - 0.011 15.9 1.0 0.011 15.9 1.0 1.6 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding DUF4795 PF16043.5 PIK54505.1 - 0.013 15.1 0.3 0.025 14.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF848 PF05852.11 PIK54505.1 - 0.015 15.4 0.2 0.049 13.8 0.0 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Jnk-SapK_ap_N PF09744.9 PIK54505.1 - 0.034 14.4 1.8 0.054 13.7 0.2 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Herpes_UL6 PF01763.16 PIK54505.1 - 0.035 12.6 0.0 0.052 12.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like CENP-H PF05837.12 PIK54505.1 - 0.041 14.3 0.2 0.041 14.3 0.2 1.7 2 0 0 2 2 1 0 Centromere protein H (CENP-H) DUF2205 PF10224.9 PIK54505.1 - 0.063 13.3 2.8 0.36 10.8 0.5 2.4 2 0 0 2 2 2 0 Short coiled-coil protein NPV_P10 PF05531.12 PIK54505.1 - 0.079 13.4 0.8 0.22 12.0 0.8 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 PIK54505.1 - 0.085 12.6 1.0 0.16 11.8 1.0 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain YabA PF06156.13 PIK54505.1 - 0.1 13.2 1.6 4.2 8.1 1.4 2.4 1 1 1 2 2 2 0 Initiation control protein YabA GAS PF13851.6 PIK54505.1 - 0.33 10.3 4.2 0.081 12.3 0.7 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding JIP_LZII PF16471.5 PIK54505.1 - 0.47 10.7 5.6 11 6.3 0.2 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II WD40_alt PF14077.6 PIK54505.1 - 0.72 9.8 5.8 0.42 10.5 0.1 2.8 3 0 0 3 3 3 0 Alternative WD40 repeat motif Tropomyosin_1 PF12718.7 PIK54505.1 - 1.1 9.4 5.8 0.13 12.4 1.1 1.8 2 0 0 2 2 1 0 Tropomyosin like bZIP_2 PF07716.15 PIK54505.1 - 1.9 8.6 6.5 2.5 8.2 2.2 2.5 2 0 0 2 2 2 0 Basic region leucine zipper DivIC PF04977.15 PIK54505.1 - 2.4 8.0 6.9 0.81 9.5 3.3 2.0 2 0 0 2 2 2 0 Septum formation initiator Cep57_CLD_2 PF14197.6 PIK54505.1 - 9.2 6.4 8.4 4.8 7.3 2.1 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 ECH_1 PF00378.20 PIK54506.1 - 1.8e-51 174.9 0.0 2.2e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK54506.1 - 8.3e-29 101.1 0.0 9.7e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase PHD PF00628.29 PIK54507.1 - 6.8e-07 29.1 6.2 1.1e-06 28.4 6.2 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 PIK54507.1 - 0.034 14.4 0.1 0.081 13.2 0.1 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-C4_Topoisom PF01396.19 PIK54507.1 - 0.054 13.3 2.1 6 6.7 0.1 2.4 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger ING PF12998.7 PIK54508.1 - 7.5e-17 61.8 2.1 9e-17 61.5 2.1 1.0 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding ApbE PF02424.15 PIK54508.1 - 0.038 13.5 0.1 0.041 13.4 0.1 1.0 1 0 0 1 1 1 0 ApbE family ISG65-75 PF11727.8 PIK54508.1 - 0.14 11.3 2.6 0.19 10.9 2.6 1.3 1 1 0 1 1 1 0 Invariant surface glycoprotein NAGLU_N PF12971.7 PIK54508.1 - 0.21 11.4 1.3 0.51 10.2 1.3 1.7 1 1 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain 7tm_1 PF00001.21 PIK54509.1 - 1.7e-29 103.0 4.0 1.7e-29 103.0 4.0 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK54509.1 - 0.00014 21.7 10.4 0.00021 21.1 10.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK54509.1 - 0.00029 20.5 22.3 0.00029 20.5 22.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CitMHS PF03600.16 PIK54509.1 - 0.15 11.3 7.7 0.26 10.5 7.7 1.6 1 1 0 1 1 1 0 Citrate transporter AIG2_2 PF13772.6 PIK54509.1 - 0.16 12.4 0.2 4.1 7.9 0.1 2.6 2 0 0 2 2 2 0 AIG2-like family Shisa PF13908.6 PIK54509.1 - 0.78 10.0 0.0 0.78 10.0 0.0 2.2 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator p450 PF00067.22 PIK54510.1 - 5.2e-92 309.0 0.0 1.7e-74 251.2 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 PIK54511.1 - 1.9e-103 346.7 0.0 2.2e-103 346.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK54512.1 - 7.8e-33 113.9 0.0 1.1e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Enterotoxin_b PF01376.18 PIK54512.1 - 0.023 14.9 0.0 0.084 13.1 0.1 1.8 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain p450 PF00067.22 PIK54513.1 - 2.6e-55 188.0 0.0 3.2e-55 187.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Copine PF07002.16 PIK54514.1 - 1.9e-86 289.0 0.1 2.6e-86 288.6 0.1 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 PIK54514.1 - 7.7e-20 71.1 0.0 6.4e-10 39.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 PIK54514.1 - 1.9e-05 24.9 0.0 3.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DIE2_ALG10 PF04922.12 PIK54515.1 - 4.8e-129 431.1 29.8 6.1e-129 430.8 29.8 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family UPF0139 PF03669.13 PIK54515.1 - 0.011 15.6 0.4 0.036 13.9 0.4 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) CN_hydrolase PF00795.22 PIK54516.1 - 4.2e-61 206.6 0.0 4.7e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Myb_DNA-bind_7 PF15963.5 PIK54517.1 - 3.6e-16 58.8 1.6 1.8e-15 56.6 1.6 2.3 1 0 0 1 1 1 1 Myb DNA-binding like Herpes_UL21 PF03252.13 PIK54517.1 - 0.11 11.2 0.9 0.19 10.5 0.9 1.4 1 0 0 1 1 1 0 Herpesvirus UL21 Rib PF08428.10 PIK54518.1 - 0.0059 16.6 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 Rib/alpha-like repeat Glyco_transf_10 PF00852.19 PIK54519.1 - 2.2e-43 148.0 1.7 3.6e-43 147.3 1.7 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK54519.1 - 4.2e-09 36.8 0.2 1.1e-08 35.5 0.2 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Pkinase_Tyr PF07714.17 PIK54520.1 - 6e-31 107.7 0.8 8e-31 107.2 0.8 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK54520.1 - 3e-17 62.9 0.5 4.4e-17 62.3 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Helo_like_N PF17111.5 PIK54520.1 - 0.042 13.2 0.2 0.079 12.3 0.2 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins V-set PF07686.17 PIK54521.1 - 1.9e-08 34.4 0.9 3.7e-05 23.9 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK54521.1 - 0.00091 19.2 0.4 0.0056 16.7 0.0 2.5 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK54521.1 - 0.084 13.5 4.4 1 10.0 0.1 3.7 3 1 1 4 4 4 0 Immunoglobulin domain Phage_XkdX PF09693.10 PIK54521.1 - 0.29 11.2 3.6 0.35 10.9 0.1 2.7 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) Ig_2 PF13895.6 PIK54521.1 - 2.7 8.4 6.3 36 4.8 0.1 4.1 3 2 0 3 3 3 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK54522.1 - 3.3e-21 75.7 0.0 3.9e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK54522.1 - 4.9e-10 39.2 0.0 6e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK54523.1 - 2.4e-12 46.7 3.6 1.8e-07 31.2 0.2 3.1 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK54523.1 - 5.6e-08 33.3 11.6 0.25 12.0 0.1 5.2 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 PIK54523.1 - 1.8e-07 31.3 0.7 0.00026 21.1 0.0 3.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK54523.1 - 0.00034 20.7 9.1 0.024 14.8 0.6 4.0 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK54523.1 - 0.01 15.9 1.3 4 7.6 0.0 3.9 3 0 0 3 3 3 0 Immunoglobulin I-set domain DUF4448 PF14610.6 PIK54523.1 - 0.049 13.4 2.3 0.062 13.1 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4448) Med12 PF09497.10 PIK54523.1 - 0.14 12.4 0.0 0.91 9.9 0.0 2.4 2 0 0 2 2 2 0 Transcription mediator complex subunit Med12 SATase_N PF06426.14 PIK54523.1 - 1.1 9.7 4.1 42 4.6 0.0 5.0 4 2 0 4 4 4 0 Serine acetyltransferase, N-terminal SKG6 PF08693.10 PIK54523.1 - 3.5 7.1 9.2 8 6.0 9.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4806 PF16064.5 PIK54523.1 - 6.1 7.2 15.2 7.4 6.9 0.1 6.1 6 0 0 6 6 5 0 Domain of unknown function (DUF4806) Ig_2 PF13895.6 PIK54523.1 - 6.5 7.2 6.7 4.7 7.6 0.0 3.7 4 1 0 4 4 4 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK54524.1 - 5.3e-05 23.2 0.2 0.0063 16.6 0.0 3.5 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK54524.1 - 6.2e-05 23.5 0.7 0.13 12.9 0.0 4.4 4 0 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK54524.1 - 0.00037 20.6 0.2 0.0037 17.4 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain Myc_target_1 PF15179.6 PIK54524.1 - 0.59 10.0 4.0 0.75 9.7 0.0 2.5 1 1 1 2 2 2 0 Myc target protein 1 Pkinase_Tyr PF07714.17 PIK54525.1 - 1.3e-16 60.6 0.0 1.5e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK54525.1 - 7.3e-08 32.1 0.0 8.2e-08 31.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK54526.1 - 5.3e-11 43.0 0.0 0.00011 22.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK54526.1 - 2.2e-07 31.0 0.6 0.0011 19.0 0.2 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK54526.1 - 5.6e-07 29.5 0.0 0.018 15.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK54526.1 - 5.3e-06 26.7 0.5 0.042 14.2 0.2 2.7 1 1 1 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 PIK54526.1 - 4.3e-05 23.0 0.0 0.33 10.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK54526.1 - 5.7e-05 23.3 0.8 0.011 15.9 0.1 2.7 1 1 1 2 2 2 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK54526.1 - 0.0013 18.7 0.1 0.89 9.7 0.0 2.3 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK54526.1 - 0.0023 18.3 2.7 0.92 10.0 0.1 3.4 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK54526.1 - 0.012 15.8 1.4 3.5 7.9 0.0 3.1 2 1 1 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Lep_receptor_Ig PF06328.11 PIK54526.1 - 0.099 12.6 0.7 0.61 10.1 0.1 2.5 3 1 0 3 3 3 0 Ig-like C2-type domain NPL PF17800.1 PIK54527.1 - 4e-06 27.3 0.0 1.1e-05 25.9 0.0 1.8 2 0 0 2 2 2 1 Nucleoplasmin-like domain SH2 PF00017.24 PIK54528.1 - 1.1e-11 44.7 0.0 5.4e-11 42.4 0.0 1.9 1 1 0 1 1 1 1 SH2 domain RVT_1 PF00078.27 PIK54529.1 - 2.5e-16 59.9 0.0 4e-16 59.2 0.0 1.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK54530.1 - 0.0011 19.4 0.1 0.0037 17.8 0.1 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK54530.1 - 0.0071 17.0 0.1 0.017 15.7 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease ADD_DNMT3 PF17980.1 PIK54530.1 - 0.029 14.3 2.5 0.07 13.1 2.5 1.6 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 SIS PF01380.22 PIK54530.1 - 0.037 13.9 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 SIS domain RRM_3 PF08777.11 PIK54530.1 - 0.085 12.9 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 RNA binding motif Asp_protease PF09668.10 PIK54530.1 - 0.09 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH PF17917.1 PIK54531.1 - 3e-29 101.4 0.0 4.6e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK54531.1 - 3.9e-27 94.2 0.2 7.9e-27 93.2 0.1 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Tudor-knot PF11717.8 PIK54532.1 - 0.0012 18.7 0.4 0.002 17.9 0.4 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 PIK54532.1 - 0.048 13.6 0.3 0.13 12.2 0.3 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Y_phosphatase PF00102.27 PIK54533.1 - 2.3e-32 112.4 1.1 6.5e-31 107.7 1.1 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK54534.1 - 5.5e-11 42.7 0.7 1.8e-06 28.2 0.5 2.7 2 0 0 2 2 2 2 Fibronectin type III domain TMEM154 PF15102.6 PIK54534.1 - 0.00074 19.4 1.5 0.00081 19.3 0.1 1.7 2 0 0 2 2 2 1 TMEM154 protein family DUF5305 PF17231.2 PIK54534.1 - 0.0033 16.9 0.4 0.0057 16.1 0.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Pur_ac_phosph_N PF16656.5 PIK54534.1 - 0.0053 17.3 3.0 0.028 15.0 2.5 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF3377 PF11857.8 PIK54534.1 - 0.056 13.4 0.4 0.13 12.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ASFV_J13L PF05568.11 PIK54534.1 - 0.061 13.1 0.6 0.061 13.1 0.6 2.3 2 1 1 3 3 3 0 African swine fever virus J13L protein Glycophorin_A PF01102.18 PIK54534.1 - 0.062 13.6 1.1 0.2 11.9 0.6 2.1 1 1 1 2 2 2 0 Glycophorin A DUF4448 PF14610.6 PIK54534.1 - 0.07 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Podoplanin PF05808.11 PIK54534.1 - 0.075 13.1 1.3 0.16 12.1 1.3 1.5 1 0 0 1 1 1 0 Podoplanin DUF2207 PF09972.9 PIK54534.1 - 0.13 11.0 0.3 0.39 9.4 0.2 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SKG6 PF08693.10 PIK54534.1 - 3.2 7.2 12.1 6.3 6.3 11.5 1.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain MAM PF00629.23 PIK54535.1 - 3.1e-106 352.2 0.1 2.6e-29 102.2 0.0 4.1 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK54535.1 - 2.2e-09 37.4 34.7 2.5e-08 34.0 15.6 3.7 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK54536.1 - 1.4e-194 639.4 9.1 3.2e-38 131.2 0.0 10.0 10 0 0 10 10 10 10 MAM domain, meprin/A5/mu MAM PF00629.23 PIK54537.1 - 3.6e-39 134.3 0.0 1.3e-21 77.1 0.0 2.3 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK54537.1 - 9.2e-07 29.0 12.7 1.6e-06 28.2 12.7 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK54538.1 - 4.3e-56 189.3 0.8 2.2e-35 121.9 0.2 3.2 3 0 0 3 3 3 3 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK54538.1 - 2.8e-14 53.0 52.2 5.6e-07 29.7 13.1 3.9 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK54539.1 - 2.3e-50 170.6 0.1 2.7e-25 89.2 0.1 2.2 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu TMEM154 PF15102.6 PIK54539.1 - 4.3e-06 26.7 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 PIK54539.1 - 0.031 13.7 0.2 0.061 12.7 0.2 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) PRIMA1 PF16101.5 PIK54539.1 - 0.058 13.4 0.3 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF3481 PF11980.8 PIK54539.1 - 0.096 12.4 2.4 0.19 11.4 2.4 1.4 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein DUF4713 PF15831.5 PIK54539.1 - 0.4 11.2 5.2 0.8 10.2 5.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Protocadherin PF08374.11 PIK54539.1 - 1.1 9.2 2.7 0.54 10.2 0.5 1.5 2 0 0 2 2 2 0 Protocadherin Insulin_TMD PF17870.1 PIK54539.1 - 1.1 9.4 5.6 2.3 8.3 5.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Ras PF00071.22 PIK54541.1 - 1.4e-50 171.0 0.1 2e-50 170.6 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK54541.1 - 1.2e-32 112.6 0.2 2.1e-32 111.9 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK54541.1 - 1.3e-14 54.0 0.0 1.7e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK54541.1 - 3.3e-07 29.9 0.1 4.7e-07 29.4 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK54541.1 - 9.8e-06 25.6 0.1 2.5e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK54541.1 - 0.0017 18.3 0.0 0.0078 16.1 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 PIK54541.1 - 0.0023 17.5 0.2 0.0093 15.5 0.1 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 PIK54541.1 - 0.0035 17.3 0.0 0.037 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 PIK54541.1 - 0.0054 16.5 0.1 0.02 14.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 PIK54541.1 - 0.0056 16.3 0.1 0.024 14.2 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 PIK54541.1 - 0.0059 15.9 0.1 0.0094 15.3 0.1 1.3 1 0 0 1 1 1 1 Septin TniB PF05621.11 PIK54541.1 - 0.0082 15.6 0.0 0.026 13.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein SRPRB PF09439.10 PIK54541.1 - 0.031 13.7 0.0 0.038 13.4 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 PIK54541.1 - 0.042 14.0 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK54541.1 - 0.046 14.0 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK54541.1 - 0.048 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 PIK54541.1 - 0.053 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 PIK54541.1 - 0.066 13.6 0.1 0.17 12.2 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain PRK PF00485.18 PIK54541.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Sigma54_activat PF00158.26 PIK54541.1 - 0.071 12.8 0.0 0.35 10.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 PIK54541.1 - 0.11 12.9 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 PIK54541.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 PIK54541.1 - 0.17 12.4 0.0 0.22 12.1 0.0 1.5 1 1 0 1 1 1 0 ABC transporter NYD-SP28_assoc PF14775.6 PIK54542.1 - 0.017 15.2 0.9 0.017 15.2 0.9 5.4 3 1 2 5 5 5 0 Sperm tail C-terminal domain EGF PF00008.27 PIK54543.1 - 2.3e-13 50.2 15.8 8.9e-08 32.3 3.4 2.8 3 0 0 3 3 3 2 EGF-like domain GPS PF01825.21 PIK54543.1 - 3.5e-12 46.7 3.1 7.2e-12 45.6 3.1 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif hEGF PF12661.7 PIK54543.1 - 0.00041 20.9 9.3 0.0021 18.6 0.8 3.5 4 0 0 4 4 4 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK54543.1 - 0.0092 16.3 16.4 0.093 13.1 3.9 2.9 3 0 0 3 3 3 2 EGF-like domain EGF_3 PF12947.7 PIK54543.1 - 5.7 7.2 17.3 0.84 9.9 0.3 3.7 3 1 1 4 4 4 0 EGF domain EGF PF00008.27 PIK54544.1 - 8e-17 61.2 12.8 2e-09 37.5 5.6 2.5 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 PIK54544.1 - 1e-06 29.1 18.2 0.00035 21.1 3.0 3.3 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK54544.1 - 2.9e-05 24.3 13.6 0.031 14.6 6.1 2.4 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 PIK54544.1 - 0.0013 18.9 10.5 0.46 10.7 0.2 3.0 2 1 0 2 2 2 2 EGF domain EGF_CA PF07645.15 PIK54544.1 - 0.13 12.5 14.8 3.1 8.1 10.1 2.4 1 1 1 2 2 2 0 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK54544.1 - 0.62 10.4 12.3 12 6.2 2.5 2.6 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site PLAT PF01477.23 PIK54545.1 - 6.5e-68 226.7 3.3 5.1e-24 85.1 0.0 3.3 3 0 0 3 3 3 3 PLAT/LH2 domain SSF PF00474.17 PIK54547.1 - 9.2e-116 387.0 8.1 1.2e-115 386.7 8.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family IBV_3C PF03620.13 PIK54547.1 - 0.083 13.4 0.3 0.29 11.6 0.3 1.9 1 0 0 1 1 1 0 IBV 3C protein RRM_1 PF00076.22 PIK54548.1 - 1.5e-33 114.5 0.2 9.8e-16 57.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK54548.1 - 8.9e-07 28.9 0.3 0.0074 16.4 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 PIK54548.1 - 1.5e-05 24.6 3.3 0.0079 15.8 1.4 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIN_5 PF08745.11 PIK54548.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 PINc domain ribonuclease Pkinase PF00069.25 PIK54549.1 - 6e-78 261.8 0.1 7.4e-78 261.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54549.1 - 9.3e-44 149.7 0.0 1.2e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK54549.1 - 5.7e-06 25.4 1.7 2.3e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 PIK54549.1 - 7e-06 25.5 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK54549.1 - 0.00019 20.8 0.0 0.00079 18.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 PIK54549.1 - 0.0068 16.0 0.9 0.012 15.3 0.9 1.3 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 PIK54549.1 - 0.056 12.9 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ribosomal_L44 PF00935.19 PIK54550.1 - 5.6e-35 119.7 11.1 5.6e-35 119.7 11.1 2.3 2 1 1 3 3 3 1 Ribosomal protein L44 Jiv90 PF14901.6 PIK54550.1 - 0.011 15.9 2.6 0.011 15.9 2.6 1.9 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone LRV_FeS PF05484.11 PIK54550.1 - 4.4 7.4 9.7 1.6 8.8 0.1 2.8 3 0 0 3 3 3 0 LRV protein FeS4 cluster Rpr2 PF04032.16 PIK54550.1 - 4.4 7.7 9.7 14 6.1 9.7 1.9 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain CUE PF02845.16 PIK54551.1 - 0.079 12.7 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 CUE domain Ig_3 PF13927.6 PIK54553.1 - 0.086 13.5 0.1 6.2 7.5 0.1 2.7 1 1 0 1 1 1 0 Immunoglobulin domain TMEM132D_C PF15706.5 PIK54553.1 - 0.22 11.3 0.6 0.7 9.7 0.6 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term His_Phos_2 PF00328.22 PIK54554.1 - 5.4e-09 35.9 0.1 7.6e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Pro_isomerase PF00160.21 PIK54555.1 - 6.3e-30 104.5 0.2 6.9e-30 104.4 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ESPR PF13018.6 PIK54556.1 - 0.068 13.0 1.1 0.11 12.3 1.1 1.4 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system COMP PF11598.8 PIK54557.1 - 2 9.0 8.1 0.31 11.5 3.2 2.2 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein MOZ_SAS PF01853.18 PIK54558.1 - 1e-76 256.6 1.2 2.7e-76 255.2 1.2 1.7 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 PIK54558.1 - 2e-23 81.8 8.2 2.2e-23 81.6 4.7 2.6 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 PIK54558.1 - 2.2e-12 46.7 2.4 2.9e-12 46.3 1.3 1.8 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 PIK54558.1 - 0.0016 18.8 0.0 0.0038 17.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_9 PF08221.11 PIK54558.1 - 0.092 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain RhoGAP PF00620.27 PIK54560.1 - 2.4e-40 137.8 0.0 4.3e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 PIK54560.1 - 2.2e-07 31.3 0.0 7.4e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 PH domain SRP40_C PF05022.12 PIK54561.1 - 4.5e-27 94.7 4.6 4.5e-27 94.7 4.6 2.0 2 0 0 2 2 2 1 SRP40, C-terminal domain Treacle PF03546.14 PIK54561.1 - 2.1e-10 40.1 217.4 0.00089 18.2 27.9 12.5 1 1 10 11 11 11 9 Treacher Collins syndrome protein Treacle Treacle PF03546.14 PIK54562.1 - 0.0014 17.5 65.2 0.015 14.1 13.6 4.2 1 1 3 4 4 4 4 Treacher Collins syndrome protein Treacle LisH PF08513.11 PIK54562.1 - 0.04 13.9 0.2 0.069 13.1 0.2 1.4 1 0 0 1 1 1 0 LisH AAA PF00004.29 PIK54563.1 - 1.9e-36 125.4 0.0 3.7e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK54563.1 - 1.7e-10 40.5 0.0 3.8e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 PIK54563.1 - 1.2e-06 29.1 0.0 0.00066 20.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK54563.1 - 2.6e-06 27.8 0.3 0.011 16.0 0.1 3.0 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 PIK54563.1 - 4.6e-06 26.5 0.0 1.5e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 PIK54563.1 - 1.6e-05 24.9 0.2 0.00039 20.4 0.2 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 PIK54563.1 - 7.9e-05 22.7 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 PIK54563.1 - 8.9e-05 22.0 0.0 0.12 11.7 0.0 2.7 2 1 1 3 3 3 2 Bacterial TniB protein IstB_IS21 PF01695.17 PIK54563.1 - 0.00027 20.7 0.0 0.0011 18.7 0.0 2.0 2 1 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 PIK54563.1 - 0.00068 19.6 0.0 0.0025 17.8 0.0 1.9 1 1 1 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 PIK54563.1 - 0.00069 19.1 0.2 0.002 17.5 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK54563.1 - 0.0007 20.0 0.1 0.0024 18.2 0.0 2.2 1 1 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 PIK54563.1 - 0.0015 18.1 0.0 0.077 12.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 PIK54563.1 - 0.0016 19.0 0.0 0.022 15.3 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 PIK54563.1 - 0.0026 17.5 0.0 0.0056 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 PIK54563.1 - 0.0034 17.5 0.0 0.0097 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 PIK54563.1 - 0.0096 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase_2 PF01637.18 PIK54563.1 - 0.013 15.4 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 PIK54563.1 - 0.014 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_21 PF13304.6 PIK54563.1 - 0.019 14.8 0.1 1.4 8.6 0.1 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 PIK54563.1 - 0.022 14.9 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 PIK54563.1 - 0.022 13.9 0.0 0.039 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase PF06745.13 PIK54563.1 - 0.033 13.5 0.2 2.3 7.5 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_28 PF13521.6 PIK54563.1 - 0.041 14.1 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK54563.1 - 0.051 14.1 0.0 0.11 13.0 0.0 1.9 1 1 0 1 1 1 0 ABC transporter TsaE PF02367.17 PIK54563.1 - 0.065 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 PIK54563.1 - 0.07 13.6 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 PIK54563.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK54563.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 PIK54563.1 - 0.12 12.3 0.1 0.39 10.6 0.0 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 PIK54563.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain SKI PF01202.22 PIK54563.1 - 0.12 12.5 0.2 0.43 10.7 0.1 1.9 2 0 0 2 2 2 0 Shikimate kinase SPO22 PF08631.10 PIK54563.1 - 0.13 11.7 0.1 4.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like SIR2 PF02146.17 PIK54564.1 - 3.6e-45 154.0 0.0 7e-45 153.1 0.0 1.5 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 PIK54564.1 - 0.0012 18.7 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) PHM7_cyt PF14703.6 PIK54564.1 - 0.02 15.2 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter zinc_ribbon_13 PF09855.9 PIK54564.1 - 0.022 14.9 0.1 0.052 13.7 0.1 1.6 1 0 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Presenilin PF01080.17 PIK54564.1 - 0.31 9.7 1.0 0.54 9.0 1.0 1.3 1 0 0 1 1 1 0 Presenilin His_Phos_2 PF00328.22 PIK54565.1 - 1.3e-10 41.2 0.0 1.9e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MAM PF00629.23 PIK54566.1 - 8.4e-95 315.1 2.3 3.3e-43 147.4 0.6 3.1 3 0 0 3 3 3 3 MAM domain, meprin/A5/mu PKD PF00801.20 PIK54566.1 - 0.36 10.7 6.0 0.064 13.1 1.0 2.3 2 0 0 2 2 2 0 PKD domain His_Phos_2 PF00328.22 PIK54567.1 - 2.5e-17 63.3 0.8 8.3e-16 58.3 0.5 2.6 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) MAM PF00629.23 PIK54569.1 - 1.1e-130 431.7 10.9 4.6e-44 150.1 0.2 3.9 4 0 0 4 4 4 3 MAM domain, meprin/A5/mu SRCR PF00530.18 PIK54569.1 - 1e-118 388.6 24.5 3.6e-30 104.4 0.5 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Zona_pellucida PF00100.23 PIK54569.1 - 3.3e-41 141.8 9.3 3.3e-41 141.8 9.3 2.2 2 0 0 2 2 2 1 Zona pellucida-like domain SRCR_2 PF15494.6 PIK54569.1 - 4.8e-25 88.0 10.9 4.1e-05 24.0 0.1 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK54569.1 - 1.3e-10 41.8 1.9 0.67 10.5 0.1 4.8 4 0 0 4 4 4 4 Hepsin, SRCR domain AMP-binding PF00501.28 PIK54570.1 - 4e-95 318.9 0.0 6.3e-95 318.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK54570.1 - 0.0007 20.5 0.0 0.0018 19.2 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LIM PF00412.22 PIK54571.1 - 7.3e-32 109.4 26.1 7.2e-15 55.0 4.1 3.2 3 0 0 3 3 3 3 LIM domain zf-dskA_traR PF01258.17 PIK54571.1 - 1.3 9.0 0.0 1.3 9.0 0.0 3.7 5 0 0 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger Yippee-Mis18 PF03226.14 PIK54571.1 - 2.8 8.2 13.6 0.12 12.5 4.4 2.6 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C3HC4 PF00097.25 PIK54571.1 - 3.1 7.8 21.0 1.4 8.8 3.8 3.8 2 2 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) LRR_4 PF12799.7 PIK54572.1 - 1.6e-09 37.9 14.0 0.016 15.7 0.3 4.9 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK54572.1 - 1.5e-07 31.1 13.0 0.18 11.6 0.7 5.1 3 1 2 5 5 5 4 Leucine rich repeat LRRNT PF01462.18 PIK54572.1 - 2.9e-05 23.6 1.0 2.9e-05 23.6 1.0 2.0 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 PIK54572.1 - 0.0086 16.5 0.6 0.019 15.5 0.6 1.6 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 PIK54572.1 - 0.25 12.0 16.3 74 4.5 0.2 6.7 7 0 0 7 7 7 0 Leucine Rich Repeat p450 PF00067.22 PIK54573.1 - 2.7e-91 306.6 2.0 1.5e-36 126.2 0.1 3.0 1 1 2 3 3 3 3 Cytochrome P450 RVT_1 PF00078.27 PIK54574.1 - 9.1e-15 54.8 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_38N PF01074.22 PIK54575.1 - 4.3e-98 328.2 9.7 4.3e-98 328.2 9.7 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 PIK54575.1 - 2.7e-35 122.4 0.0 5.6e-35 121.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 PIK54575.1 - 1.7e-20 72.9 2.3 2.3e-20 72.5 0.1 2.5 3 0 0 3 3 3 1 Alpha mannosidase middle domain HSP70 PF00012.20 PIK54576.1 - 1.4e-83 281.1 4.4 1.6e-83 280.9 4.4 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF3038 PF11237.8 PIK54576.1 - 0.00033 20.8 1.0 0.00055 20.0 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3038) Z1 PF10593.9 PIK54576.1 - 0.17 11.3 5.6 0.25 10.8 5.6 1.1 1 0 0 1 1 1 0 Z1 domain DUF3813 PF12758.7 PIK54576.1 - 2.9 8.3 6.1 0.88 9.9 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3813) HSP70 PF00012.20 PIK54577.1 - 3.5e-144 481.3 1.7 4.2e-144 481.0 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK54577.1 - 2.7e-14 52.7 0.1 2.3e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein MetOD2 PF18548.1 PIK54577.1 - 0.015 15.4 0.0 0.033 14.3 0.0 1.6 1 0 0 1 1 1 0 Metanogen output domain 2 FtsA PF14450.6 PIK54577.1 - 0.017 15.5 0.5 1.7 9.1 0.3 2.7 2 1 0 2 2 2 0 Cell division protein FtsA StbA PF06406.11 PIK54577.1 - 0.044 13.0 0.1 0.11 11.7 0.1 1.4 1 1 0 1 1 1 0 StbA protein DDR PF08841.10 PIK54577.1 - 0.056 12.4 0.1 0.083 11.9 0.1 1.3 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 PIK54577.1 - 0.059 12.6 1.3 0.1 11.8 0.2 1.9 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase zf-C3HC4_2 PF13923.6 PIK54578.1 - 2.1e-08 33.9 9.5 2.1e-08 33.9 9.5 3.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK54578.1 - 2.2e-08 33.8 11.5 2.2e-08 33.8 11.5 3.5 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54578.1 - 2.1e-07 31.1 8.8 2.1e-07 31.1 8.8 3.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK54578.1 - 2.4e-07 30.5 10.0 2.4e-07 30.5 10.0 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK54578.1 - 3.7e-07 30.0 3.6 3.7e-07 30.0 3.6 3.4 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK54578.1 - 3.1e-06 27.2 9.9 3.1e-06 27.2 9.9 3.8 3 2 1 4 4 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK54578.1 - 7.1e-06 25.9 6.7 7.1e-06 25.9 6.7 3.7 3 1 0 3 3 2 1 zinc-RING finger domain zf-B_box PF00643.24 PIK54578.1 - 2e-05 24.6 28.1 5.6e-05 23.2 12.0 3.8 4 0 0 4 4 3 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK54578.1 - 0.00014 21.7 11.3 0.00014 21.7 11.3 3.6 3 1 0 3 3 2 1 Prokaryotic RING finger family 4 DUF2935 PF11155.8 PIK54578.1 - 0.041 14.2 4.8 0.097 13.0 4.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) HAUS6_N PF14661.6 PIK54578.1 - 0.045 13.3 12.6 0.074 12.6 12.6 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus UPF0061 PF02696.14 PIK54578.1 - 0.089 11.6 2.7 0.12 11.2 2.7 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family TetR_C_24 PF17932.1 PIK54578.1 - 4.8 7.5 5.5 2 8.7 1.3 2.4 1 1 2 3 3 3 0 Tetracyclin repressor-like, C-terminal domain UPF0242 PF06785.11 PIK54578.1 - 5.2 7.1 20.6 46 4.0 20.7 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mitofilin PF09731.9 PIK54578.1 - 6.1 5.5 24.0 8.9 5.0 24.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein V-ATPase_G PF03179.15 PIK54578.1 - 6.3 7.4 21.7 3.8 8.1 13.8 2.8 1 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit NACHT PF05729.12 PIK54580.1 - 0.00023 21.1 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK54580.1 - 0.002 17.7 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK54580.1 - 0.024 14.9 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK54580.1 - 0.07 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK54580.1 - 0.13 12.6 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 PIK54580.1 - 0.17 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Y_phosphatase PF00102.27 PIK54581.1 - 2.3e-70 236.8 3.4 4e-31 108.4 0.1 3.1 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK54581.1 - 1.6e-07 31.2 0.2 4e-06 26.7 0.0 2.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK54581.1 - 2.1e-05 24.7 0.0 0.00037 20.6 0.0 2.6 2 1 0 2 2 2 1 Inositol hexakisphosphate RsgA_GTPase PF03193.16 PIK54581.1 - 0.00049 20.0 0.0 0.0014 18.6 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase Y_phosphatase2 PF03162.13 PIK54581.1 - 0.0006 19.4 0.3 0.0016 18.1 0.1 1.9 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 PIK54581.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family fn3 PF00041.21 PIK54582.1 - 1.2e-17 64.0 9.1 3.2e-09 37.0 0.8 3.1 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK54582.1 - 2.1e-05 25.0 9.2 0.028 15.0 1.3 3.1 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK54582.1 - 5.5e-05 23.4 0.0 0.059 13.7 0.0 2.6 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 PIK54582.1 - 0.046 13.9 1.5 7.7 6.7 0.1 3.1 3 0 0 3 3 3 0 Fibronectin type III domain WIF PF02019.18 PIK54582.1 - 0.053 13.2 0.3 0.72 9.6 0.0 2.7 3 0 0 3 3 3 0 WIF domain SusE PF14292.6 PIK54582.1 - 0.16 12.2 11.3 0.34 11.2 0.2 3.9 3 2 0 3 3 3 0 SusE outer membrane protein CYLD_phos_site PF16607.5 PIK54582.1 - 0.2 11.5 1.3 8.3 6.2 0.2 2.3 2 0 0 2 2 2 0 Phosphorylation region of CYLD, unstructured Y_phosphatase PF00102.27 PIK54583.1 - 4e-56 190.2 1.1 7.6e-56 189.3 1.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK54583.1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate fn3 PF00041.21 PIK54584.1 - 3.3e-19 69.0 4.7 1.5e-09 38.0 0.7 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK54584.1 - 0.00038 21.0 7.7 0.026 15.1 0.7 3.1 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK54584.1 - 0.0044 17.3 0.0 4.8 7.6 0.0 2.6 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III TRAP_beta PF05753.14 PIK54584.1 - 0.12 11.7 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) CHB_HEX_C_1 PF13290.6 PIK54584.1 - 0.73 9.9 6.1 0.14 12.2 1.4 2.4 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain RT_RNaseH_2 PF17919.1 PIK54585.1 - 4.2e-30 103.7 0.0 6.9e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK54585.1 - 5.7e-27 94.1 0.0 9.5e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK54585.1 - 1.3e-19 70.6 0.0 2.2e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK54586.1 - 9.1e-08 32.6 0.3 2.3e-07 31.2 0.1 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK54586.1 - 2e-05 25.2 0.1 5.6e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 Aspartyl protease fn3 PF00041.21 PIK54587.1 - 8.8e-18 64.4 8.1 2.4e-08 34.2 0.3 2.9 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK54587.1 - 0.00053 20.5 11.0 0.014 15.9 0.3 3.3 3 2 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK54587.1 - 0.0026 18.1 0.0 3.4 8.0 0.0 2.5 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III CHB_HEX_C_1 PF13290.6 PIK54587.1 - 0.064 13.3 2.7 0.094 12.7 1.2 2.2 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain rve PF00665.26 PIK54590.1 - 1.5e-21 76.8 0.0 5.3e-21 75.0 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK54590.1 - 2.1e-20 72.5 1.1 4.4e-20 71.5 1.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK54590.1 - 0.0024 18.0 0.6 0.0058 16.8 0.6 1.7 1 0 0 1 1 1 1 H2C2 zinc finger 2_5_RNA_ligase2 PF13563.6 PIK54590.1 - 0.0062 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK54590.1 - 0.039 13.7 0.0 0.11 12.3 0.0 1.9 1 1 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 PIK54591.1 - 7.1e-23 80.5 0.1 1.2e-22 79.9 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK54591.1 - 1.8e-09 37.8 0.1 2.9e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK54591.1 - 0.00037 20.1 0.0 0.00059 19.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK54592.1 - 0.0094 16.0 1.4 0.0094 16.0 1.4 2.8 2 0 0 2 2 2 1 Zinc knuckle zinc_ribbon_2 PF13240.6 PIK54592.1 - 0.27 11.0 3.8 58 3.6 3.8 3.0 1 1 0 1 1 1 0 zinc-ribbon domain RT_RNaseH_2 PF17919.1 PIK54593.1 - 3.3e-28 97.6 0.0 5.7e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK54593.1 - 4.5e-23 81.5 0.0 6.8e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK54593.1 - 0.023 14.5 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like Y_phosphatase PF00102.27 PIK54594.1 - 1.8e-123 410.7 11.7 3.3e-70 236.3 3.5 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK54594.1 - 4.2e-14 52.5 1.5 1e-05 25.4 0.2 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK54594.1 - 1.8e-10 41.0 4.6 2.2e-08 34.3 0.4 3.5 3 0 0 3 3 3 2 Fibronectin type III domain PTPlike_phytase PF14566.6 PIK54594.1 - 1.1e-06 28.9 0.0 0.00024 21.2 0.0 3.1 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK54594.1 - 1.2e-06 28.7 0.0 0.0015 18.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 PIK54594.1 - 0.00033 20.3 0.3 0.0035 16.9 0.2 2.5 2 0 0 2 2 2 1 Tyrosine phosphatase family TMEM154 PF15102.6 PIK54594.1 - 0.038 13.9 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.8 PIK54594.1 - 0.057 13.4 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CHB_HEX_C_1 PF13290.6 PIK54594.1 - 0.17 11.9 1.8 0.74 9.9 1.8 2.1 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain SKG6 PF08693.10 PIK54594.1 - 1.4 8.4 6.6 3 7.4 6.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pur_ac_phosph_N PF16656.5 PIK54594.1 - 1.8 9.2 11.1 0.46 11.1 0.4 3.6 4 0 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain DJ-1_PfpI PF01965.24 PIK54596.1 - 2.4e-16 60.0 0.0 2.5e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 PIK54596.1 - 0.00022 20.9 0.0 0.00025 20.7 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain ThiJ_like PF17124.5 PIK54596.1 - 0.05 13.3 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like SPRY PF00622.28 PIK54597.1 - 2.1e-15 56.9 0.0 3.8e-15 56.1 0.0 1.4 1 1 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 PIK54597.1 - 6.1e-10 39.3 1.0 9.5e-10 38.7 1.0 1.3 1 0 0 1 1 1 1 SOCS box MIF4G PF02854.19 PIK54598.1 - 2.9e-48 164.3 14.1 2.9e-48 164.3 14.1 2.4 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 PIK54598.1 - 4.4e-25 87.9 0.1 1.4e-24 86.2 0.1 1.9 1 0 0 1 1 1 1 MA3 domain W2 PF02020.18 PIK54598.1 - 3.9e-12 46.1 0.0 1.3e-11 44.4 0.0 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon eIF_4G1 PF12152.8 PIK54598.1 - 0.0029 17.7 0.1 0.0029 17.7 0.1 2.7 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 4G1 Borrelia_P83 PF05262.11 PIK54599.1 - 0.005 15.4 10.4 0.0061 15.1 10.4 1.0 1 0 0 1 1 1 1 Borrelia P83/100 protein Bombinin PF05298.11 PIK54599.1 - 0.039 13.6 4.6 0.76 9.5 0.5 2.1 1 1 1 2 2 2 0 Bombinin HIP1_clath_bdg PF16515.5 PIK54599.1 - 0.36 11.5 22.4 0.047 14.3 12.8 2.9 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exonuc_VII_L PF02601.15 PIK54599.1 - 2.1 7.9 10.7 2.5 7.6 10.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 PIK54599.1 - 4.3 6.3 12.3 5.4 6.0 12.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nup88 PF10168.9 PIK54599.1 - 8.1 4.1 16.6 9.5 3.9 16.6 1.1 1 0 0 1 1 1 0 Nuclear pore component ZU5 PF00791.20 PIK54600.1 - 3.8e-10 40.0 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK54600.1 - 0.00013 22.2 0.2 0.00026 21.2 0.2 1.5 1 0 0 1 1 1 1 Death effector domain MA3 PF02847.17 PIK54601.1 - 8.6e-12 45.0 0.6 3.3e-11 43.2 0.1 2.3 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 PIK54601.1 - 7.9e-11 42.0 8.6 8.2e-07 28.9 4.9 2.6 1 1 1 2 2 2 2 MIF4G domain W2 PF02020.18 PIK54601.1 - 8.4e-09 35.5 0.1 3.1e-06 27.2 0.0 3.6 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon eIF_4G1 PF12152.8 PIK54601.1 - 0.0016 18.6 0.6 0.46 10.7 0.0 3.7 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 4G1 CNOT11 PF10155.9 PIK54601.1 - 0.043 14.0 3.1 0.082 13.1 0.4 2.7 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 CENP-F_C_Rb_bdg PF10490.9 PIK54601.1 - 0.43 10.0 1.6 9.9 5.7 0.0 3.1 3 0 0 3 3 3 0 Rb-binding domain of kinetochore protein Cenp-F/LEK1 MIF4G PF02854.19 PIK54603.1 - 5.7e-11 42.5 7.6 4e-10 39.7 7.6 2.0 1 1 0 1 1 1 1 MIF4G domain RHINO PF15319.6 PIK54603.1 - 0.41 10.6 15.8 0.018 15.1 7.1 2.6 1 1 1 2 2 2 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein IFT57 PF10498.9 PIK54604.1 - 0.00016 20.7 14.1 0.00024 20.2 14.1 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Lebercilin PF15619.6 PIK54604.1 - 0.0032 17.2 16.3 0.0071 16.0 16.3 1.6 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.8 PIK54604.1 - 0.0056 16.7 17.3 0.0094 15.9 7.7 2.5 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 PIK54604.1 - 0.015 15.4 5.9 0.023 14.7 5.9 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 PIK54604.1 - 0.043 13.2 3.9 0.05 12.9 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 PIK54604.1 - 0.071 13.6 7.8 0.36 11.3 5.1 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF812 PF05667.11 PIK54604.1 - 0.089 11.7 12.3 0.13 11.2 12.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Phage_GP20 PF06810.11 PIK54604.1 - 0.095 12.5 10.9 0.17 11.7 10.9 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 Atg14 PF10186.9 PIK54604.1 - 0.16 11.1 14.9 0.026 13.6 11.1 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tektin PF03148.14 PIK54604.1 - 0.2 10.4 14.2 5.9 5.5 12.2 2.4 2 0 0 2 2 2 0 Tektin family DUF724 PF05266.14 PIK54604.1 - 0.24 11.2 13.4 0.62 9.9 12.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HemX PF04375.14 PIK54604.1 - 0.25 10.6 13.9 0.44 9.8 13.9 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase OEP PF02321.18 PIK54604.1 - 0.27 11.0 12.8 0.46 10.3 12.8 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein SKA1 PF07160.12 PIK54604.1 - 0.32 10.8 12.4 0.53 10.1 12.4 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 FlaC_arch PF05377.11 PIK54604.1 - 0.32 11.4 8.0 4.6 7.7 3.9 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) HR1 PF02185.16 PIK54604.1 - 0.76 9.9 18.9 11 6.3 7.2 2.7 1 1 1 2 2 2 0 Hr1 repeat ABC_tran_CTD PF16326.5 PIK54604.1 - 0.81 10.0 13.5 4.2 7.7 3.7 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain MAD PF05557.13 PIK54604.1 - 0.81 8.0 16.9 1.1 7.5 16.9 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF3552 PF12072.8 PIK54604.1 - 0.87 9.0 14.9 1.6 8.1 14.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) SlyX PF04102.12 PIK54604.1 - 1 10.1 21.9 0.058 14.0 9.1 3.0 2 1 1 3 3 3 0 SlyX V_ATPase_I PF01496.19 PIK54604.1 - 2.2 6.1 8.2 2.7 5.8 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 PIK54604.1 - 2.7 6.5 11.4 3.8 6.0 11.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-CpG_bind_C PF12269.8 PIK54604.1 - 2.7 7.7 8.0 2.6 7.8 6.8 1.6 1 1 0 1 1 1 0 CpG binding protein zinc finger C terminal domain CCDC-167 PF15188.6 PIK54604.1 - 2.9 8.3 10.8 2.4 8.6 8.8 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 PIK54604.1 - 3.4 7.7 10.6 4.4 7.4 2.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 PIK54604.1 - 4.1 7.4 14.1 7.8 6.5 14.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Prominin PF05478.11 PIK54604.1 - 4.3 5.2 10.6 5.6 4.8 10.6 1.1 1 0 0 1 1 1 0 Prominin Fzo_mitofusin PF04799.13 PIK54604.1 - 7 6.2 13.5 4.7 6.7 3.5 2.2 1 1 1 2 2 2 0 fzo-like conserved region DUF16 PF01519.16 PIK54604.1 - 8.2 7.0 11.4 30 5.2 11.4 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF948 PF06103.11 PIK54604.1 - 8.3 6.8 7.4 29 5.0 6.4 2.3 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.13 PIK54604.1 - 9.9 6.3 13.1 16 5.7 8.7 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PROCN PF08083.11 PIK54605.1 - 7.5e-177 588.1 14.2 2.1e-103 346.2 3.8 2.8 3 1 0 3 3 3 2 PROCN (NUC071) domain U5_2-snRNA_bdg PF10597.9 PIK54605.1 - 5.9e-73 243.3 0.0 1.1e-72 242.4 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 PIK54605.1 - 3.6e-48 161.8 1.0 9.3e-48 160.5 1.0 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PRP8_domainIV PF12134.8 PIK54606.1 - 2.6e-130 433.0 0.7 4.7e-130 432.1 0.7 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 PIK54606.1 - 3.9e-90 299.9 4.0 5.7e-90 299.4 2.8 2.0 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PROCT PF08084.11 PIK54606.1 - 3.1e-54 182.1 0.0 6.3e-54 181.1 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 PIK54606.1 - 4.8e-12 45.9 0.0 1e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DDHD PF02862.17 PIK54607.1 - 1.2e-38 133.5 5.3 5.1e-25 89.0 0.8 3.0 2 1 1 3 3 3 2 DDHD domain LNS2 PF08235.13 PIK54607.1 - 8.2e-05 22.2 0.4 0.0046 16.5 0.4 2.4 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) IP_trans PF02121.18 PIK54608.1 - 2e-57 194.6 0.0 2.2e-57 194.5 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein LLC1 PF14945.6 PIK54610.1 - 2.8e-23 82.7 2.0 3.7e-22 79.1 0.3 2.4 2 1 0 2 2 2 1 Normal lung function maintenance, Low in Lung Cancer 1 protein PC_rep PF01851.22 PIK54610.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Proteasome/cyclosome repeat V-SNARE_C PF12352.8 PIK54611.1 - 3.2e-07 30.5 10.4 2.3e-05 24.6 4.5 2.6 2 1 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus CENP-H PF05837.12 PIK54611.1 - 0.011 16.1 1.1 0.011 16.1 1.1 2.6 3 1 0 3 3 3 0 Centromere protein H (CENP-H) DUF5089 PF17002.5 PIK54611.1 - 0.036 14.0 14.0 0.35 10.7 14.0 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) V_ATPase_I PF01496.19 PIK54611.1 - 1.1 7.1 8.0 1.3 6.9 8.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family XhlA PF10779.9 PIK54611.1 - 6.8 7.0 7.9 19 5.6 0.1 2.8 3 0 0 3 3 3 0 Haemolysin XhlA Presenilin PF01080.17 PIK54611.1 - 9.7 4.8 6.1 13 4.5 6.1 1.2 1 0 0 1 1 1 0 Presenilin RIC3 PF15361.6 PIK54611.1 - 9.9 6.5 7.2 26 5.2 1.3 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 BCAS3 PF12490.8 PIK54612.1 - 2e-28 99.6 0.0 3.8e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 PIK54612.1 - 0.013 16.3 1.1 2 9.4 0.3 3.4 2 1 0 2 2 2 0 WD domain, G-beta repeat 14-3-3 PF00244.20 PIK54613.1 - 5.2e-55 186.3 2.9 8.4e-55 185.7 2.9 1.2 1 0 0 1 1 1 1 14-3-3 protein zf-TRM13_CCCH PF11722.8 PIK54613.1 - 0.28 11.0 1.3 0.87 9.4 1.3 1.9 1 1 0 1 1 1 0 CCCH zinc finger in TRM13 protein TMEM208_SND2 PF05620.11 PIK54614.1 - 0.3 10.8 0.7 0.5 10.1 0.7 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 NACHT PF05729.12 PIK54616.1 - 3.4e-06 27.1 0.0 5.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK54616.1 - 0.00015 21.5 0.2 0.00044 19.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 PIK54616.1 - 0.00067 19.0 0.0 0.00098 18.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 PIK54616.1 - 0.0021 17.4 0.0 0.0026 17.1 0.0 1.4 1 1 0 1 1 1 1 KaiC AAA_16 PF13191.6 PIK54616.1 - 0.015 15.7 0.0 0.019 15.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 PIK54616.1 - 0.026 15.1 0.0 0.043 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 PIK54616.1 - 0.031 14.3 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DAP3 PF10236.9 PIK54616.1 - 0.033 13.3 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK54616.1 - 0.063 13.6 0.0 0.09 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 PIK54616.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ZU5 PF00791.20 PIK54617.1 - 8.9e-15 54.8 0.1 4.5e-14 52.6 0.0 2.2 2 0 0 2 2 2 1 ZU5 domain Death PF00531.22 PIK54617.1 - 3.7e-11 43.0 0.2 8.8e-11 41.8 0.2 1.6 1 0 0 1 1 1 1 Death domain DUF927 PF06048.11 PIK54617.1 - 0.11 12.0 0.3 0.18 11.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF927) DUF3362 PF11842.8 PIK54617.1 - 0.45 10.8 0.0 0.45 10.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3362) fn3 PF00041.21 PIK54618.1 - 0.016 15.5 0.1 0.024 14.9 0.1 1.3 1 0 0 1 1 1 0 Fibronectin type III domain DUF2369 PF10179.9 PIK54618.1 - 0.032 14.6 0.1 0.045 14.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Tristanin_u2 PF16638.5 PIK54618.1 - 0.054 14.3 0.0 0.061 14.2 0.0 1.2 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers 7tm_1 PF00001.21 PIK54619.1 - 4e-42 144.4 13.3 5.6e-42 143.9 13.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK54619.1 - 1.2e-08 34.6 10.2 2.4e-08 33.7 10.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK54619.1 - 5.3e-08 32.8 14.4 5.3e-08 32.8 14.4 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1980 PF09323.10 PIK54619.1 - 0.73 9.7 4.8 0.18 11.7 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1980) 7tm_1 PF00001.21 PIK54620.1 - 1.3e-35 123.1 9.9 1.7e-35 122.7 9.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK54620.1 - 1.4e-07 31.4 10.9 1.4e-07 31.4 10.9 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK54620.1 - 7.8e-06 25.4 4.4 0.00012 21.6 4.4 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK54620.1 - 0.0026 17.2 8.1 0.016 14.6 8.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Phospholamban PF04272.14 PIK54620.1 - 0.08 12.4 1.9 0.41 10.2 1.9 2.2 1 0 0 1 1 1 0 Phospholamban DUF621 PF04789.15 PIK54620.1 - 0.53 9.4 7.6 0.2 10.8 4.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF621) Methyltransf_31 PF13847.6 PIK54621.1 - 0.011 15.5 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 PIK54621.1 - 0.012 16.2 0.0 0.016 15.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain EI24 PF07264.11 PIK54622.1 - 7.2e-26 91.5 14.4 9.8e-26 91.1 14.4 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) TPH PF13868.6 PIK54624.1 - 2.4e-79 266.4 125.6 2.4e-79 266.4 125.6 2.1 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain RITA PF17066.5 PIK54624.1 - 0.0021 17.7 0.7 0.0021 17.7 0.7 2.4 3 0 0 3 3 3 1 RBPJ-interacting and tubulin associated protein TGS PF02824.21 PIK54625.1 - 0.00011 22.2 0.0 0.00023 21.1 0.0 1.5 1 0 0 1 1 1 1 TGS domain Ig_3 PF13927.6 PIK54626.1 - 3.2e-49 165.4 8.7 3.8e-11 43.4 0.1 5.7 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK54626.1 - 4.3e-43 145.3 5.2 5.5e-09 36.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.25 PIK54626.1 - 3.7e-39 132.8 6.3 1.3e-08 34.8 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 PIK54626.1 - 8.6e-35 118.9 8.3 2.5e-06 27.7 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 PIK54626.1 - 6.7e-30 103.5 4.1 2.8e-08 33.9 0.0 6.1 5 1 0 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK54626.1 - 3.5e-11 43.0 2.9 1.4e-07 31.5 0.1 5.3 5 1 0 5 5 5 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK54626.1 - 3.9e-08 33.6 1.2 0.15 12.5 0.1 5.6 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 PIK54626.1 - 0.0044 17.2 1.0 0.88 9.8 0.1 3.8 1 1 2 3 3 3 1 Natural killer cell receptor 2B4 Shisa PF13908.6 PIK54626.1 - 0.013 15.7 3.8 0.019 15.2 0.3 2.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator OppC_N PF12911.7 PIK54626.1 - 0.016 15.2 1.3 0.032 14.2 1.3 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF4834 PF16118.5 PIK54626.1 - 0.019 15.9 3.6 0.73 10.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Peptidase_M56 PF05569.11 PIK54626.1 - 0.054 12.7 0.2 0.088 12.0 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF3139 PF11337.8 PIK54626.1 - 0.14 12.8 0.5 0.33 11.6 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) ETRAMP PF09716.10 PIK54626.1 - 0.31 11.1 1.6 0.83 9.8 0.2 2.4 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) TMEM154 PF15102.6 PIK54626.1 - 0.83 9.6 3.1 0.5 10.3 0.3 2.0 2 0 0 2 2 2 0 TMEM154 protein family Ig_3 PF13927.6 PIK54627.1 - 1.5e-21 76.7 0.1 2.8e-15 56.7 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK54627.1 - 1.2e-20 73.4 0.0 6e-16 58.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK54627.1 - 3.7e-19 68.8 0.2 8.6e-14 51.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK54627.1 - 1.5e-15 57.1 2.5 1.4e-11 44.3 0.1 2.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK54627.1 - 7.6e-06 26.1 1.2 1 9.5 0.0 4.1 2 2 1 3 3 3 3 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK54627.1 - 0.0013 19.0 0.2 0.029 14.6 0.0 2.5 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 PIK54627.1 - 0.025 15.0 0.2 0.14 12.6 0.0 2.2 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.6 PIK54628.1 - 6.1e-29 100.5 0.2 1.8e-15 57.3 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK54628.1 - 1.4e-28 98.8 0.0 2e-16 59.8 0.0 2.0 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK54628.1 - 2.1e-21 76.0 0.2 2e-11 44.0 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK54628.1 - 9e-19 67.4 0.1 6.1e-10 39.1 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK54628.1 - 1e-12 48.1 1.4 0.033 14.3 0.0 4.1 2 2 2 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK54628.1 - 6.3e-07 29.7 0.0 0.035 14.5 0.0 2.5 2 1 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 PIK54628.1 - 2.5e-06 27.5 0.1 0.01 15.9 0.1 2.5 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK54628.1 - 0.00011 21.7 0.0 0.42 10.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.5 PIK54628.1 - 0.00037 20.7 0.0 1.2 9.4 0.0 2.8 2 1 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK54628.1 - 0.0035 17.7 0.2 0.24 11.8 0.0 2.9 2 2 0 2 2 2 1 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 PIK54628.1 - 0.014 15.4 0.1 3.2 7.9 0.0 2.7 2 2 0 2 2 2 0 C17orf99 Ig domain I-set PF07679.16 PIK54629.1 - 2.8e-44 149.1 0.0 1.2e-13 50.9 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54629.1 - 2.5e-41 140.1 0.4 1.3e-14 54.5 0.0 3.9 4 0 0 4 4 3 3 Immunoglobulin domain fn3 PF00041.21 PIK54629.1 - 1.8e-39 134.0 8.9 8.1e-12 45.3 0.1 4.5 4 0 0 4 4 4 3 Fibronectin type III domain ig PF00047.25 PIK54629.1 - 2.4e-27 94.9 0.5 3.6e-11 43.1 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK54629.1 - 3.8e-26 91.2 0.1 7.1e-09 35.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK54629.1 - 1e-21 77.1 2.9 2.3e-06 27.8 0.0 5.2 5 2 0 5 5 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK54629.1 - 8.6e-08 32.2 0.5 0.068 13.2 0.1 3.5 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK54629.1 - 1.3e-06 28.9 2.5 0.022 15.3 0.0 4.7 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.5 PIK54629.1 - 2e-06 27.9 0.1 2.8 8.3 0.0 4.3 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK54629.1 - 0.00033 20.7 0.0 1.3 9.1 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 PIK54629.1 - 0.00059 19.4 0.0 0.16 11.6 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Interfer-bind PF09294.10 PIK54629.1 - 0.0016 18.7 0.1 0.3 11.4 0.0 2.7 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III C2-set PF05790.15 PIK54629.1 - 0.04 14.1 0.0 86 3.4 0.0 3.7 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Lipoprotein_8 PF02030.15 PIK54629.1 - 0.16 10.7 0.2 0.24 10.1 0.2 1.1 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) Sigma70_ner PF04546.13 PIK54629.1 - 1.3 8.8 3.2 2 8.2 3.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region fn3 PF00041.21 PIK54630.1 - 0.00018 21.8 0.1 0.00049 20.4 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain BRO1 PF03097.18 PIK54632.1 - 1.7e-15 56.7 0.2 2e-15 56.5 0.2 1.0 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 PIK54633.1 - 5.8e-49 167.0 17.9 4.5e-41 141.1 11.9 2.2 1 1 1 2 2 2 2 ALIX V-shaped domain binding to HIV DUF1456 PF07308.13 PIK54633.1 - 0.053 13.9 0.2 1.7 9.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) Lipase_GDSL PF00657.22 PIK54633.1 - 0.058 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase AIM5 PF17050.5 PIK54633.1 - 0.071 13.9 0.4 4.6 8.1 0.0 3.6 3 1 0 3 3 3 0 Altered inheritance of mitochondria 5 ING PF12998.7 PIK54633.1 - 0.32 11.6 3.1 0.28 11.8 0.8 2.0 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding MIEAP PF16026.5 PIK54633.1 - 2.5 8.3 7.0 2 8.6 4.4 2.1 2 1 0 2 2 2 0 Mitochondria-eating protein HEXIM PF15313.6 PIK54634.1 - 8.5e-24 84.4 10.7 1.8e-22 80.1 10.7 2.2 1 1 0 1 1 1 1 Hexamethylene bis-acetamide-inducible protein Mad3_BUB1_II PF08171.11 PIK54634.1 - 0.088 13.0 0.6 0.16 12.1 0.6 1.5 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 DUF4023 PF13215.6 PIK54635.1 - 0.1 12.6 4.4 0.24 11.4 4.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Ribul_P_3_epim PF00834.19 PIK54636.1 - 4.3e-39 134.0 3.0 1.6e-38 132.1 0.3 2.0 1 1 1 2 2 2 2 Ribulose-phosphate 3 epimerase family Radical_SAM PF04055.21 PIK54636.1 - 0.25 11.7 1.5 1.6 9.1 0.0 2.8 2 1 1 3 3 3 0 Radical SAM superfamily Myosin_head PF00063.21 PIK54637.1 - 2.9e-235 782.6 6.1 1.8e-169 565.2 0.8 2.3 1 1 1 2 2 2 2 Myosin head (motor domain) IQ PF00612.27 PIK54637.1 - 4.6e-21 72.6 39.1 7.6e-06 25.3 4.4 6.7 6 0 0 6 6 6 6 IQ calmodulin-binding motif AAA_22 PF13401.6 PIK54637.1 - 0.02 15.2 0.3 0.074 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK54637.1 - 0.044 14.2 2.2 0.067 13.6 0.0 2.5 2 2 0 2 2 2 0 AAA ATPase domain DIL PF01843.19 PIK54638.1 - 7.7e-30 103.2 0.9 2.9e-29 101.4 0.9 2.1 1 0 0 1 1 1 1 DIL domain FlaC_arch PF05377.11 PIK54638.1 - 0.041 14.3 0.4 0.041 14.3 0.4 5.1 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) HTH_17 PF12728.7 PIK54638.1 - 0.14 12.4 0.2 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HU-CCDC81_bac_2 PF18175.1 PIK54638.1 - 0.79 9.6 5.4 0.17 11.8 0.7 2.4 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Dynein_light PF01221.18 PIK54638.1 - 1.3 9.4 5.2 0.85 10.0 2.4 2.2 2 0 0 2 2 2 0 Dynein light chain type 1 Vir_act_alpha_C PF10400.9 PIK54638.1 - 2.6 8.8 9.9 0.21 12.3 2.3 3.1 2 1 0 2 2 2 0 Virulence activator alpha C-term LytTR PF04397.15 PIK54641.1 - 0.24 11.6 1.1 10 6.4 0.0 2.8 3 0 0 3 3 3 0 LytTr DNA-binding domain Metallophos PF00149.28 PIK54642.1 - 3.6e-23 83.1 0.0 3.6e-22 79.9 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK54642.1 - 1.1e-13 51.4 3.0 2.3e-13 50.4 3.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain MyTH4 PF00784.17 PIK54643.1 - 2.1e-23 82.9 0.2 8.6e-23 80.9 0.3 2.1 2 0 0 2 2 2 1 MyTH4 domain SH3_2 PF07653.17 PIK54643.1 - 3.2e-14 52.3 0.0 7.7e-14 51.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK54643.1 - 3e-10 39.8 0.0 1.1e-09 38.0 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK54643.1 - 4e-09 35.9 0.0 1e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain RET_CLD1 PF17756.1 PIK54643.1 - 0.12 12.6 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 RET Cadherin like domain 1 Myosin_head PF00063.21 PIK54644.1 - 1.5e-205 684.4 4.8 2.4e-205 683.8 4.8 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 PIK54644.1 - 5.9e-24 84.7 2.3 6.8e-24 84.4 0.0 2.4 2 0 0 2 2 2 1 MyTH4 domain IQ PF00612.27 PIK54644.1 - 8.6e-05 22.0 23.6 0.073 12.9 3.0 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif AAA_22 PF13401.6 PIK54644.1 - 0.016 15.4 1.7 0.1 12.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain MYO10_CC PF16735.5 PIK54644.1 - 0.051 13.7 0.2 0.051 13.7 0.2 4.1 4 0 0 4 4 4 0 Unconventional myosin-X coiled coil domain Paz_1 PF18349.1 PIK54644.1 - 0.07 13.1 0.0 0.27 11.2 0.0 2.0 1 0 0 1 1 1 0 PAZ domain AAA_16 PF13191.6 PIK54644.1 - 0.18 12.2 0.0 0.18 12.2 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 PIK54645.1 - 2.6e-40 136.7 0.1 4.6e-40 135.9 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 PIK54645.1 - 8.1e-23 80.7 0.0 1.6e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 PIK54645.1 - 4.4e-21 74.7 0.1 7.8e-21 73.9 0.1 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 PIK54645.1 - 3.9e-12 46.0 0.0 6.7e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK54645.1 - 0.00011 22.3 0.1 0.42 10.6 0.0 2.4 1 1 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 PIK54645.1 - 0.0077 16.1 0.3 0.084 12.8 0.0 2.6 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 PIK54645.1 - 0.015 15.7 0.0 0.049 14.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 PIK54645.1 - 0.016 15.5 0.0 0.054 13.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 PIK54645.1 - 0.018 14.6 0.9 8 6.0 0.0 3.4 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 PIK54645.1 - 0.031 14.5 0.1 0.072 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 PIK54645.1 - 0.035 13.5 0.2 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MeaB PF03308.16 PIK54645.1 - 0.11 11.5 0.6 0.21 10.6 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 PIK54645.1 - 0.12 12.6 0.0 0.6 10.3 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 PIK54645.1 - 0.13 12.7 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter 7tm_1 PF00001.21 PIK54646.1 - 7.5e-28 97.6 11.2 7.5e-28 97.6 11.2 1.6 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK54646.1 - 4e-05 23.4 16.3 5e-05 23.1 16.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK54646.1 - 0.0012 18.6 5.5 0.0017 18.1 5.5 1.3 1 1 0 1 1 1 1 Olfactory receptor PSI_PsaH PF03244.14 PIK54646.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI Glyco_transf_10 PF00852.19 PIK54647.1 - 2e-50 170.9 1.5 3.7e-50 170.1 1.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK54647.1 - 8.9e-09 35.8 0.1 3.1e-08 34.0 0.1 2.0 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DUF4306 PF14154.6 PIK54647.1 - 0.065 13.4 0.7 5.9 7.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4306) DUF4834 PF16118.5 PIK54647.1 - 0.086 13.8 0.4 0.18 12.8 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Glyco_transf_10 PF00852.19 PIK54648.1 - 6.8e-51 172.5 1.1 9.7e-51 172.0 1.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term 7tm_1 PF00001.21 PIK54649.1 - 7.2e-25 87.8 5.5 8e-25 87.6 5.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK54649.1 - 0.0012 18.6 0.3 0.0014 18.5 0.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK54649.1 - 0.016 14.9 1.4 0.016 14.9 1.4 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Pkinase PF00069.25 PIK54650.1 - 7.7e-67 225.4 0.0 1.1e-66 225.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PH_3 PF14593.6 PIK54650.1 - 1.3e-44 150.5 0.7 3e-44 149.4 0.0 1.9 2 0 0 2 2 2 1 PH domain Pkinase_Tyr PF07714.17 PIK54650.1 - 2.1e-32 112.4 0.0 3.1e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK54650.1 - 3.9e-08 33.0 0.0 1.6e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 PIK54650.1 - 7.1e-08 31.8 0.0 1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 PIK54650.1 - 5.1e-05 22.2 0.1 8.7e-05 21.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK54650.1 - 0.00041 20.3 0.2 0.0026 17.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 PIK54650.1 - 0.0017 18.0 0.2 1.3 8.6 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 PIK54650.1 - 0.0022 17.4 0.7 0.004 16.5 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH_8 PF15409.6 PIK54650.1 - 0.059 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain RIO1 PF01163.22 PIK54650.1 - 0.072 12.7 0.4 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 RIO1 family LRR_4 PF12799.7 PIK54651.1 - 5.5e-30 102.9 53.6 1.8e-07 31.4 4.5 6.4 1 1 8 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK54651.1 - 2e-27 94.8 22.1 1e-12 47.6 7.5 4.1 1 1 2 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 PIK54651.1 - 1.8e-07 30.9 11.4 0.00031 20.3 3.2 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK54651.1 - 6.8e-06 25.9 24.0 3.9 8.4 0.1 9.0 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK54651.1 - 0.0073 16.3 0.2 0.21 11.6 0.0 2.1 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) RsmF_methylt_CI PF17126.5 PIK54651.1 - 0.027 14.5 0.4 5.5 7.1 0.0 3.8 1 1 4 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain LRR_6 PF13516.6 PIK54651.1 - 1.3 9.2 29.9 4.3 7.6 0.1 8.1 9 0 0 9 9 9 0 Leucine Rich repeat XPG_I PF00867.18 PIK54652.1 - 1.4e-25 89.4 0.2 5.7e-24 84.3 0.2 2.6 1 1 0 1 1 1 1 XPG I-region XPG_N PF00752.17 PIK54652.1 - 2.1e-19 69.8 0.9 3.4e-19 69.2 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 PIK54652.1 - 5.2e-07 30.2 0.0 1.6e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold RPA_interact_C PF14768.6 PIK54652.1 - 0.027 15.0 0.9 12 6.6 0.1 2.4 2 0 0 2 2 2 0 Replication protein A interacting C-terminal HHH_2 PF12826.7 PIK54652.1 - 0.1 12.7 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 PIK54652.1 - 0.14 12.8 0.0 0.35 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain DEAD PF00270.29 PIK54653.1 - 1.6e-39 135.4 0.0 5.8e-39 133.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK54653.1 - 2.3e-21 76.2 0.1 1.6e-20 73.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 PIK54653.1 - 0.0088 16.3 0.5 0.068 13.4 0.1 2.8 2 1 0 2 2 2 1 AAA domain XRCC4 PF06632.12 PIK54654.1 - 0.16 10.8 7.3 0.19 10.5 7.3 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 APC_u5 PF16630.5 PIK54654.1 - 0.2 12.7 4.1 0.087 13.9 1.5 1.7 1 1 1 2 2 2 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs CDC45 PF02724.14 PIK54654.1 - 2.2 6.4 7.5 2.7 6.2 7.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Kelch_1 PF01344.25 PIK54655.1 - 4.7e-35 118.9 10.6 1.6e-11 43.6 0.3 6.3 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 PIK54655.1 - 7.9e-25 86.9 2.2 1.3e-24 86.3 1.4 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 PIK54655.1 - 3.5e-24 85.2 0.4 1.5e-23 83.1 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 PIK54655.1 - 2.8e-19 68.3 2.7 1.2e-07 31.4 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 PIK54655.1 - 1.8e-18 66.1 10.2 0.00025 21.2 0.0 6.2 3 2 3 6 6 6 4 Kelch motif Kelch_4 PF13418.6 PIK54655.1 - 3e-17 62.4 0.1 0.0015 18.5 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK54655.1 - 2.2e-16 59.7 0.6 3.8e-05 23.8 0.1 5.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK54655.1 - 1.4e-09 37.7 0.8 0.0016 18.4 0.1 4.2 5 0 0 5 5 5 3 Kelch motif BTB_3 PF16017.5 PIK54655.1 - 0.036 14.2 0.4 0.16 12.1 0.1 2.0 2 0 0 2 2 2 0 BTB/POZ domain ACOX PF01756.19 PIK54655.1 - 0.068 12.7 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Acyl-CoA oxidase Carm_PH PF17888.1 PIK54656.1 - 2.4e-07 31.0 0.0 2.9e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 Carmil pleckstrin homology domain CARMIL_C PF16000.5 PIK54657.1 - 3.7e-37 128.6 20.6 3.7e-37 128.6 20.6 5.4 3 1 1 4 4 4 1 CARMIL C-terminus LRR_6 PF13516.6 PIK54657.1 - 1.9e-12 46.2 30.6 0.00024 20.9 0.1 11.3 12 0 0 12 12 12 3 Leucine Rich repeat LRR_4 PF12799.7 PIK54657.1 - 0.0016 18.8 34.7 0.014 15.8 0.1 7.4 4 3 5 9 9 9 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK54657.1 - 0.0044 17.4 21.3 25 5.9 0.1 9.3 9 0 0 9 9 9 1 Leucine Rich Repeat GLTT PF01744.20 PIK54657.1 - 0.42 10.4 1.4 0.82 9.5 1.4 1.4 1 0 0 1 1 1 0 GLTT repeat (6 copies) LRR_8 PF13855.6 PIK54657.1 - 0.55 10.0 25.7 0.5 10.2 0.1 7.4 5 3 3 8 8 8 0 Leucine rich repeat LRR_5 PF13306.6 PIK54657.1 - 1.9 8.5 7.2 6.7 6.7 1.7 3.3 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) ECH_1 PF00378.20 PIK54658.1 - 1.3e-44 152.4 0.0 1.6e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK54658.1 - 4.6e-20 72.4 0.0 4.2e-19 69.2 0.0 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase zf-B_box PF00643.24 PIK54659.1 - 1.7e-10 40.9 20.2 1.1e-07 31.9 6.4 4.1 5 0 0 5 5 5 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK54659.1 - 1.2e-09 38.1 4.0 1.2e-09 38.1 4.0 3.8 3 2 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54659.1 - 3.9e-09 36.2 6.8 3.9e-09 36.2 6.8 3.8 3 2 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54659.1 - 9.2e-08 32.3 7.0 9.2e-08 32.3 7.0 3.6 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 PIK54659.1 - 2.9e-07 30.2 8.9 2.9e-07 30.2 8.9 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK54659.1 - 5.7e-07 29.3 5.3 5.7e-07 29.3 5.3 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK54659.1 - 7.8e-07 29.0 6.2 7.8e-07 29.0 6.2 4.6 3 2 1 4 4 4 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK54659.1 - 8.7e-07 29.0 7.3 8.7e-07 29.0 7.3 4.0 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 PIK54659.1 - 0.0012 18.7 17.4 0.12 12.3 3.6 3.5 3 0 0 3 3 3 3 zf-RING of BARD1-type protein zf-ribbon_3 PF13248.6 PIK54659.1 - 0.0041 16.5 0.5 0.0041 16.5 0.5 5.0 6 0 0 6 6 6 1 zinc-ribbon domain Prok-RING_4 PF14447.6 PIK54659.1 - 0.016 15.1 8.0 0.016 15.1 8.0 4.5 4 1 1 5 5 5 0 Prokaryotic RING finger family 4 Siva PF05458.12 PIK54659.1 - 0.021 14.5 21.6 0.099 12.3 3.7 3.1 2 1 0 3 3 3 0 Cd27 binding protein (Siva) DUF1759 PF03564.15 PIK54659.1 - 0.042 13.8 0.2 0.094 12.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) zf-Sec23_Sec24 PF04810.15 PIK54659.1 - 0.3 11.2 0.1 0.3 11.2 0.1 4.4 5 0 0 5 5 4 0 Sec23/Sec24 zinc finger zf-WRNIP1_ubi PF18279.1 PIK54659.1 - 4 8.3 10.1 8 7.4 0.2 3.9 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain IBR PF01485.21 PIK54659.1 - 9 6.6 31.9 0.36 11.1 6.5 3.9 3 1 1 4 4 4 0 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 PIK54661.1 - 1.3e-09 37.9 3.5 1.3e-09 37.9 3.5 3.6 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54661.1 - 6.3e-09 35.6 6.2 6.3e-09 35.6 6.2 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK54661.1 - 9.4e-09 35.3 20.2 7.2e-07 29.3 6.0 3.8 4 0 0 4 4 3 2 B-box zinc finger zf-C3HC4_2 PF13923.6 PIK54661.1 - 9.6e-08 31.7 7.9 9.6e-08 31.7 7.9 3.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54661.1 - 2e-07 31.2 6.8 2e-07 31.2 6.8 4.1 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK54661.1 - 6.6e-07 29.1 4.5 6.6e-07 29.1 4.5 3.8 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK54661.1 - 1.2e-06 28.5 7.1 1.2e-06 28.5 7.1 3.9 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK54661.1 - 2.6e-06 27.3 5.7 2.6e-06 27.3 5.7 4.4 3 2 0 3 3 3 1 zinc-RING finger domain ArfGap PF01412.18 PIK54661.1 - 0.00083 19.4 2.4 0.00083 19.4 2.4 2.8 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf zf-ribbon_3 PF13248.6 PIK54661.1 - 0.0066 15.8 0.7 0.0066 15.8 0.7 3.8 5 0 0 5 5 5 1 zinc-ribbon domain Rotavirus_VP3 PF06929.11 PIK54661.1 - 0.016 13.5 0.1 0.025 12.8 0.1 1.2 1 0 0 1 1 1 0 Rotavirus VP3 protein zf-Sec23_Sec24 PF04810.15 PIK54661.1 - 0.07 13.2 5.5 0.91 9.6 0.0 3.7 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Exonuc_VII_L PF02601.15 PIK54661.1 - 0.13 11.8 4.0 0.28 10.7 4.0 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING_6 PF14835.6 PIK54661.1 - 0.14 12.1 19.6 0.077 12.9 3.7 3.7 3 0 0 3 3 3 0 zf-RING of BARD1-type protein Apolipoprotein PF01442.18 PIK54661.1 - 0.16 11.9 7.7 0.29 11.0 7.7 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Phasin PF05597.11 PIK54661.1 - 0.55 10.2 5.2 1.1 9.3 5.2 1.5 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.12 PIK54661.1 - 2.2 8.3 4.9 14 5.7 4.8 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FeoB_Cyto PF17910.1 PIK54661.1 - 3.1 8.4 6.0 1.6 9.3 3.0 2.1 2 0 0 2 2 1 0 FeoB cytosolic helical domain Siva PF05458.12 PIK54661.1 - 3.1 7.4 22.5 0.59 9.8 4.4 3.1 2 1 1 3 3 3 0 Cd27 binding protein (Siva) zf-rbx1 PF12678.7 PIK54661.1 - 4.9 7.5 10.8 0.17 12.2 2.9 2.7 2 0 0 2 2 1 0 RING-H2 zinc finger domain AAA PF00004.29 PIK54662.1 - 6.3e-42 143.1 0.0 9.3e-42 142.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 PIK54662.1 - 1.7e-26 92.0 0.0 3.9e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_16 PF13191.6 PIK54662.1 - 3.1e-06 27.7 0.0 0.00044 20.7 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK54662.1 - 2.5e-05 24.3 0.0 9.2e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 PIK54662.1 - 2.6e-05 24.3 0.0 6.2e-05 23.0 0.0 1.6 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.13 PIK54662.1 - 2.8e-05 23.5 0.0 6.7e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_lid_3 PF17862.1 PIK54662.1 - 3e-05 23.7 0.0 8.6e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 PIK54662.1 - 4.1e-05 23.9 0.1 0.0059 16.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK54662.1 - 5.9e-05 22.9 0.0 9.5e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 PIK54662.1 - 6.2e-05 22.8 0.0 9.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 PIK54662.1 - 0.00026 21.1 0.0 0.00042 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 PIK54662.1 - 0.00067 18.9 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 PIK54662.1 - 0.00068 19.3 0.2 0.49 9.9 0.1 2.3 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 PIK54662.1 - 0.00072 20.1 0.0 0.0016 19.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK54662.1 - 0.0037 17.4 0.0 0.0063 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK54662.1 - 0.0039 16.9 0.0 0.0068 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK54662.1 - 0.004 17.5 0.0 0.0077 16.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 PIK54662.1 - 0.007 16.3 0.0 0.47 10.3 0.0 2.2 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK54662.1 - 0.0081 15.7 0.0 0.023 14.2 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region Parvo_NS1 PF01057.17 PIK54662.1 - 0.022 13.9 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 PIK54662.1 - 0.023 14.6 0.0 0.18 11.7 0.0 2.0 1 1 1 2 2 2 0 NACHT domain AAA_17 PF13207.6 PIK54662.1 - 0.023 15.1 0.0 0.039 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 PIK54662.1 - 0.023 14.1 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 PIK54662.1 - 0.024 14.4 0.0 0.066 12.9 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain KAP_NTPase PF07693.14 PIK54662.1 - 0.026 13.8 0.1 3.8 6.6 0.1 2.3 1 1 1 2 2 2 0 KAP family P-loop domain ATPase PF06745.13 PIK54662.1 - 0.028 13.8 0.1 6 6.1 0.0 2.1 1 1 1 2 2 2 0 KaiC TniB PF05621.11 PIK54662.1 - 0.033 13.6 0.0 6.5 6.1 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein PhoH PF02562.16 PIK54662.1 - 0.041 13.3 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.6 PIK54662.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 PIK54662.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 PIK54662.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase Zeta_toxin PF06414.12 PIK54662.1 - 0.18 11.1 0.0 0.49 9.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin MCM PF00493.23 PIK54662.1 - 0.19 10.8 0.0 0.36 9.9 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Aldolase_II PF00596.21 PIK54663.1 - 1.7e-16 60.7 0.6 2.5e-16 60.1 0.6 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Cyanate_lyase PF02560.14 PIK54663.1 - 0.15 11.9 0.1 16 5.5 0.0 2.6 2 0 0 2 2 2 0 Cyanate lyase C-terminal domain Cys_rich_FGFR PF00839.17 PIK54664.1 - 1.4e-37 127.6 15.0 4.1e-13 49.3 2.1 4.1 4 0 0 4 4 4 4 Cysteine rich repeat Gypsy PF07253.11 PIK54664.1 - 0.11 11.1 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Gypsy protein Cys_rich_FGFR PF00839.17 PIK54665.1 - 4e-60 199.8 51.3 5.2e-12 45.7 2.8 7.3 7 0 0 7 7 7 7 Cysteine rich repeat NUC130_3NT PF08158.12 PIK54665.1 - 0.004 17.4 0.4 2 8.8 0.1 3.3 4 0 0 4 4 4 2 NUC130/3NT domain SAM_LFY PF01698.16 PIK54665.1 - 0.075 13.0 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain DUF1011 PF06237.12 PIK54666.1 - 8.2e-25 87.0 8.0 8.2e-25 87.0 8.0 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF1011) DUF4131 PF13567.6 PIK54666.1 - 0.4 10.3 4.6 5.1 6.7 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) adh_short PF00106.25 PIK54667.1 - 6.1e-48 162.9 0.1 1e-47 162.1 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK54667.1 - 2.4e-35 122.2 0.0 5.5e-35 121.0 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK54667.1 - 1.5e-09 38.0 0.0 3.2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 KR domain TPR_12 PF13424.6 PIK54667.1 - 0.00012 22.3 0.0 0.061 13.6 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54667.1 - 0.01 15.9 0.5 2.9 8.2 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat adh_short PF00106.25 PIK54668.1 - 4.1e-29 101.5 0.3 5.2e-29 101.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK54668.1 - 4.8e-18 65.6 0.0 6.2e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF2316 PF10078.9 PIK54668.1 - 0.0075 16.5 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) RabGAP-TBC PF00566.18 PIK54670.1 - 9.8e-19 67.9 0.5 1.5e-18 67.3 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DHHC PF01529.20 PIK54671.1 - 0.0065 16.6 0.6 0.0088 16.1 0.6 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase SID-1_RNA_chan PF13965.6 PIK54671.1 - 0.17 10.3 0.0 0.23 9.8 0.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NS3_envE PF02723.14 PIK54671.1 - 0.33 11.1 2.7 0.61 10.2 2.7 1.3 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E NLRC4_HD PF17889.1 PIK54673.1 - 0.045 14.1 0.3 0.84 10.0 0.1 2.1 1 1 1 2 2 2 0 NLRC4 helical domain BDHCT PF08072.11 PIK54673.1 - 0.092 12.8 1.0 0.17 12.0 1.0 1.4 1 0 0 1 1 1 0 BDHCT (NUC031) domain PAP2 PF01569.21 PIK54675.1 - 6.2e-31 107.0 1.6 2.8e-30 104.9 0.9 2.0 2 0 0 2 2 2 1 PAP2 superfamily ANAPC10 PF03256.16 PIK54676.1 - 5.3e-72 241.3 0.1 6.1e-72 241.2 0.1 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 PIK54676.1 - 0.00048 20.2 0.1 0.00083 19.5 0.1 1.4 1 1 0 1 1 1 1 F5/8 type C domain PITH PF06201.13 PIK54676.1 - 0.0013 18.9 0.5 0.007 16.6 0.1 1.9 1 1 1 2 2 2 1 PITH domain XRCC1_N PF01834.16 PIK54676.1 - 0.013 15.5 0.1 0.37 10.8 0.0 2.1 1 1 1 2 2 2 0 XRCC1 N terminal domain AA_kinase PF00696.28 PIK54677.1 - 6.9e-31 107.7 0.0 1.3e-30 106.7 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family F-box-like PF12937.7 PIK54678.1 - 3.8e-06 26.7 0.4 1.2e-05 25.1 0.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK54678.1 - 2e-05 24.3 1.1 7.3e-05 22.5 1.1 2.0 1 1 0 1 1 1 1 F-box domain zf-Di19 PF05605.12 PIK54678.1 - 0.011 16.0 0.9 0.026 14.8 0.2 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ATPase PF06745.13 PIK54678.1 - 0.069 12.5 0.5 0.17 11.2 0.5 1.6 1 0 0 1 1 1 0 KaiC Cut12 PF11500.8 PIK54678.1 - 0.077 13.0 2.0 0.18 11.7 2.0 1.6 1 0 0 1 1 1 0 Spindle pole body formation-associated protein DUF4200 PF13863.6 PIK54678.1 - 0.35 11.3 7.4 0.97 9.8 7.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) OrsD PF12013.8 PIK54678.1 - 0.5 10.8 2.8 4.4 7.8 0.2 2.9 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D EABR PF12180.8 PIK54679.1 - 1.7e-05 24.3 2.0 3.6e-05 23.3 2.0 1.5 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 OmpH PF03938.14 PIK54679.1 - 0.01 16.2 10.1 0.01 16.2 10.1 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) WD40_alt PF14077.6 PIK54679.1 - 0.014 15.3 0.3 0.04 13.8 0.3 1.8 1 0 0 1 1 1 0 Alternative WD40 repeat motif Sec8_exocyst PF04048.14 PIK54679.1 - 0.022 14.6 2.4 0.022 14.6 2.4 2.5 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain Laminin_II PF06009.12 PIK54679.1 - 0.054 13.5 11.2 0.056 13.5 9.5 1.9 1 1 1 2 2 2 0 Laminin Domain II KapB PF08810.10 PIK54679.1 - 0.97 9.6 7.2 0.11 12.7 0.9 2.4 1 1 1 3 3 3 0 Kinase associated protein B ACP_PD PF04336.12 PIK54679.1 - 1 9.8 7.1 5.9 7.4 0.8 2.5 1 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase CC2-LZ PF16516.5 PIK54679.1 - 1.1 9.7 24.7 2 8.8 12.6 2.9 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Fib_alpha PF08702.10 PIK54679.1 - 2.7 8.2 22.2 0.39 10.9 5.3 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family 7tm_3 PF00003.22 PIK54680.1 - 4.6e-23 82.2 15.9 5.7e-23 81.9 15.9 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1129 PF06570.11 PIK54680.1 - 0.17 11.4 2.0 0.31 10.5 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TatC PF00902.18 PIK54680.1 - 0.84 9.4 6.7 0.48 10.2 3.9 1.8 1 1 1 2 2 2 0 Sec-independent protein translocase protein (TatC) 7tm_3 PF00003.22 PIK54681.1 - 9.4e-34 117.2 19.8 1.4e-33 116.7 19.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR EF-hand_7 PF13499.6 PIK54683.1 - 2.4e-26 91.9 0.8 1.9e-18 66.7 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK54683.1 - 1.1e-25 87.2 2.9 1.9e-07 30.1 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK54683.1 - 3.9e-22 76.2 0.9 1e-05 25.0 0.0 4.4 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 PIK54683.1 - 1.5e-20 71.7 0.3 5.8e-07 28.7 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 PIK54683.1 - 3.5e-16 58.8 3.3 0.00017 21.4 0.2 3.6 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK54683.1 - 1.6e-07 31.7 0.4 0.0015 18.8 0.0 3.5 1 1 2 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK54683.1 - 2.5e-06 27.4 0.6 0.18 11.8 0.0 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 PIK54683.1 - 0.00063 19.9 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 2 Dockerin type I domain EF-hand_9 PF14658.6 PIK54683.1 - 0.073 13.4 0.1 11 6.4 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain FG-GAP PF01839.23 PIK54683.1 - 0.27 11.4 4.6 2.3 8.4 0.3 2.3 2 0 0 2 2 2 0 FG-GAP repeat RAI16-like PF10257.9 PIK54685.1 - 2.2e-108 362.4 3.9 2.9e-108 362.0 3.9 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DUF3361 PF11841.8 PIK54685.1 - 0.43 10.5 2.3 1.5 8.7 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) BAR PF03114.18 PIK54686.1 - 2.8e-23 82.8 9.5 4.7e-23 82.1 9.5 1.3 1 0 0 1 1 1 1 BAR domain Vps5 PF09325.10 PIK54686.1 - 2.9e-10 40.1 7.2 5.7e-10 39.1 7.2 1.5 1 1 0 1 1 1 1 Vps5 C terminal like BAR_3 PF16746.5 PIK54686.1 - 6.6e-06 26.0 11.0 9.3e-06 25.5 11.0 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Smac_DIABLO PF09057.10 PIK54686.1 - 0.025 13.9 0.1 0.039 13.3 0.1 1.4 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases DUF5082 PF16888.5 PIK54686.1 - 1 9.6 11.2 0.35 11.2 0.8 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) PCO_ADO PF07847.12 PIK54687.1 - 1.5e-42 145.3 0.0 1.9e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 PCO_ADO zf-C2H2 PF00096.26 PIK54688.1 - 1.2e-15 57.0 17.4 1.2e-05 25.5 0.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK54688.1 - 2e-15 56.4 23.6 2.8e-08 33.8 1.9 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54688.1 - 3.5e-08 33.6 19.2 0.0028 18.4 2.0 4.0 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2HC_2 PF13913.6 PIK54688.1 - 0.00015 21.6 10.4 0.07 13.0 0.8 3.5 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 PIK54688.1 - 0.02 15.2 3.4 25 5.3 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK54688.1 - 0.023 14.4 8.5 0.37 10.6 0.1 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type Zf_RING PF16744.5 PIK54688.1 - 0.075 13.2 2.8 0.81 9.8 0.1 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C2H2_6 PF13912.6 PIK54688.1 - 0.091 12.8 5.1 1.1 9.3 0.5 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 PIK54688.1 - 0.45 11.0 7.5 5.9 7.4 0.5 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK54688.1 - 0.48 10.5 9.2 8.5 6.5 9.2 2.5 1 1 0 1 1 1 0 BED zinc finger HNH PF01844.23 PIK54688.1 - 5.1 7.4 6.9 11 6.3 0.1 3.2 3 0 0 3 3 3 0 HNH endonuclease zf-CHY PF05495.12 PIK54688.1 - 6 7.4 7.4 41 4.8 6.9 2.4 1 1 0 1 1 1 0 CHY zinc finger Lectin_leg-like PF03388.13 PIK54689.1 - 2.5e-31 108.8 0.0 3.5e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 PIK54689.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial lectin Lectin_leg-like PF03388.13 PIK54690.1 - 4.3e-92 307.6 0.1 5.2e-92 307.4 0.1 1.0 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 PIK54690.1 - 3.6e-08 33.7 0.2 6.1e-08 32.9 0.2 1.3 1 0 0 1 1 1 1 Bacterial lectin Laminin_G_2 PF02210.24 PIK54690.1 - 0.0038 17.8 0.0 0.0073 16.9 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain EGF_3 PF12947.7 PIK54691.1 - 0.014 15.6 7.0 0.022 15.0 7.0 1.3 1 0 0 1 1 1 0 EGF domain cEGF PF12662.7 PIK54691.1 - 0.057 13.4 0.7 0.057 13.4 0.7 3.0 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK54691.1 - 0.059 13.6 5.3 0.11 12.7 5.3 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF PF00008.27 PIK54691.1 - 0.063 13.6 5.2 0.12 12.7 5.2 1.5 1 0 0 1 1 1 0 EGF-like domain FXa_inhibition PF14670.6 PIK54691.1 - 0.086 13.1 5.5 0.18 12.1 5.5 1.5 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site TMIE PF16038.5 PIK54691.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 TMIE protein OAD_gamma PF04277.13 PIK54691.1 - 0.25 12.0 2.2 0.42 11.2 2.2 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain hEGF PF12661.7 PIK54691.1 - 3.1 8.6 6.0 24 5.7 6.0 2.5 1 1 0 1 1 1 0 Human growth factor-like EGF Sushi PF00084.20 PIK54692.1 - 4.6e-13 49.6 31.6 0.0011 19.5 0.4 6.4 5 2 1 6 6 6 4 Sushi repeat (SCR repeat) Brix PF04427.18 PIK54693.1 - 6.8e-36 124.2 0.3 6.8e-36 124.2 0.3 2.0 2 0 0 2 2 2 1 Brix domain MAPEG PF01124.18 PIK54695.1 - 3.8e-09 36.5 1.3 4.4e-08 33.1 0.6 2.4 1 1 1 2 2 2 1 MAPEG family Trypsin PF00089.26 PIK54696.1 - 2.4e-07 30.8 0.0 4.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.15 PIK54696.1 - 0.015 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 PIK54696.1 - 0.12 13.3 0.0 0.24 12.3 0.0 1.6 1 0 0 1 1 1 0 Trypsin-like peptidase domain Acyltransf_C PF16076.5 PIK54697.1 - 1.9e-19 69.5 0.2 4.5e-19 68.3 0.2 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 PIK54697.1 - 1.5e-12 47.3 0.0 2.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase TSNAXIP1_N PF15739.5 PIK54698.1 - 2.9e-20 72.7 2.8 6.6e-20 71.5 0.0 2.6 2 1 1 3 3 3 1 Translin-associated factor X-interacting N-terminus GAS PF13851.6 PIK54698.1 - 0.0023 17.3 2.3 0.0023 17.3 2.3 2.3 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 PIK54698.1 - 0.024 13.7 1.5 0.039 13.0 0.7 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4404 PF14357.6 PIK54698.1 - 0.076 13.7 0.5 0.076 13.7 0.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) ADIP PF11559.8 PIK54698.1 - 0.091 12.8 9.3 0.12 12.4 2.3 2.9 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 PIK54698.1 - 0.18 12.1 2.2 55 4.1 0.0 3.3 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 PIK54698.1 - 0.21 11.8 10.1 0.14 12.4 6.8 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DegS PF05384.11 PIK54698.1 - 0.43 10.0 6.4 4.4 6.8 1.0 2.8 2 1 1 3 3 3 0 Sensor protein DegS DUF848 PF05852.11 PIK54698.1 - 0.65 10.1 4.4 1.5 8.9 3.5 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Fez1 PF06818.15 PIK54698.1 - 0.7 10.3 11.5 0.089 13.2 1.1 2.6 1 1 0 2 2 2 0 Fez1 Mod_r PF07200.13 PIK54698.1 - 0.82 9.8 14.3 0.39 10.8 1.2 3.2 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 PIK54698.1 - 1.4 9.6 11.7 5.7 7.6 0.1 3.6 3 1 0 3 3 2 0 Initiation control protein YabA COG5 PF10392.9 PIK54698.1 - 1.6 8.9 6.0 2.1 8.5 2.1 2.7 1 1 1 2 2 2 0 Golgi transport complex subunit 5 TSC22 PF01166.18 PIK54698.1 - 3.8 7.9 7.5 22 5.4 0.3 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.21 PIK54698.1 - 4.1 7.6 9.8 3.9 7.7 0.5 3.4 3 0 0 3 3 3 0 bZIP transcription factor Snapin_Pallidin PF14712.6 PIK54698.1 - 5 7.6 15.5 0.54 10.7 5.7 3.1 2 1 0 3 3 2 0 Snapin/Pallidin Laminin_II PF06009.12 PIK54698.1 - 5.6 7.0 10.7 0.6 10.1 3.6 2.5 2 1 1 3 3 3 0 Laminin Domain II ZapB PF06005.12 PIK54698.1 - 6.6 7.3 10.2 1.1 9.8 0.7 3.0 2 1 0 2 2 2 0 Cell division protein ZapB fn3_3 PF14686.6 PIK54699.1 - 0.035 13.9 0.4 7.9 6.3 0.3 3.0 2 1 0 2 2 2 0 Polysaccharide lyase family 4, domain II BBIP10 PF14777.6 PIK54699.1 - 0.16 11.6 0.0 0.43 10.2 0.0 1.7 2 0 0 2 2 2 0 Cilia BBSome complex subunit 10 TFIID-18kDa PF02269.16 PIK54700.1 - 2e-36 123.9 0.4 2.5e-36 123.6 0.4 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Hist_deacetyl PF00850.19 PIK54701.1 - 6.7e-77 259.0 0.0 8.9e-77 258.6 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain adh_short PF00106.25 PIK54702.1 - 2.2e-25 89.3 0.1 2.7e-25 89.0 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK54702.1 - 8.5e-21 74.6 0.0 1e-20 74.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK54702.1 - 9.5e-09 35.4 0.1 1.3e-08 35.0 0.1 1.2 1 0 0 1 1 1 1 KR domain MoCF_biosynth PF00994.24 PIK54702.1 - 0.0052 16.5 0.7 0.0056 16.4 0.0 1.4 2 0 0 2 2 2 1 Probable molybdopterin binding domain Epimerase PF01370.21 PIK54702.1 - 0.023 14.1 0.1 0.03 13.8 0.1 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 PIK54703.1 - 2.5e-07 30.5 0.0 2.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.6 PIK54705.1 - 1.8e-43 148.8 0.0 2.2e-43 148.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK54705.1 - 1.6e-30 106.0 0.0 2.1e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK54705.1 - 0.00051 20.0 0.0 0.00074 19.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK54705.1 - 0.0097 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 PIK54706.1 - 1.2e-31 110.1 12.7 1.5e-31 109.8 12.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK54706.1 - 4.6e-26 91.6 23.0 1.9e-18 66.6 17.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Dpy19 PF10034.9 PIK54707.1 - 2.2e-154 515.2 18.3 1.4e-108 363.9 2.3 3.0 2 1 1 3 3 3 3 Q-cell neuroblast polarisation Spond_N PF06468.13 PIK54708.1 - 0.093 12.8 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Spondin_N ANTH PF07651.16 PIK54710.1 - 1.3e-53 181.8 1.9 1.5e-53 181.6 1.9 1.0 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 PIK54710.1 - 4.4e-06 26.8 0.1 7.4e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 ENTH domain Hamartin PF04388.12 PIK54711.1 - 4.8 5.7 8.0 5.8 5.4 8.0 1.0 1 0 0 1 1 1 0 Hamartin protein Myosin_head PF00063.21 PIK54712.1 - 4.6e-231 768.7 10.2 4.6e-231 768.7 10.2 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.5 PIK54712.1 - 1.5e-37 127.5 0.2 1.6e-36 124.2 0.1 2.7 2 0 0 2 2 2 1 Myosin VI cargo binding domain Myosin_N PF02736.19 PIK54712.1 - 1e-05 25.3 0.3 0.00015 21.6 0.0 2.4 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 PIK54712.1 - 0.039 14.4 0.0 0.039 14.4 0.0 3.3 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 PIK54712.1 - 0.45 10.8 0.0 0.45 10.8 0.0 4.0 3 1 1 4 4 4 0 AAA domain Mcl1_mid PF12341.8 PIK54713.1 - 0.11 11.9 0.1 0.77 9.1 0.0 1.9 1 1 1 2 2 2 0 Minichromosome loss protein, Mcl1, middle region ZU5 PF00791.20 PIK54714.1 - 2.3e-15 56.7 0.0 4.3e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Tim17 PF02466.19 PIK54715.1 - 1.2e-14 54.6 1.4 1.4e-14 54.4 1.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family GHMP_kinases_N PF00288.26 PIK54715.1 - 0.087 13.1 5.4 0.088 13.1 0.6 2.2 1 1 0 2 2 2 0 GHMP kinases N terminal domain RNase_T PF00929.24 PIK54716.1 - 1.5e-26 93.9 0.0 2e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF3599 PF12206.8 PIK54716.1 - 0.074 13.4 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3599) ETC_C1_NDUFA5 PF04716.14 PIK54716.1 - 0.16 11.8 0.0 0.98 9.3 0.0 2.1 2 0 0 2 2 2 0 ETC complex I subunit conserved region BAR_3_WASP_bdg PF10456.9 PIK54717.1 - 0.0015 18.0 3.2 0.0018 17.8 3.1 1.3 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein XhlA PF10779.9 PIK54717.1 - 0.0036 17.5 2.5 0.0036 17.5 2.5 3.9 2 2 2 4 4 4 1 Haemolysin XhlA Transposase_22 PF02994.14 PIK54717.1 - 0.015 15.5 4.0 0.021 15.0 1.0 2.7 1 1 2 3 3 3 0 L1 transposable element RBD-like domain PPR_long PF17177.4 PIK54717.1 - 0.024 14.0 0.1 0.042 13.2 0.1 1.5 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Semialdhyde_dhC PF02774.18 PIK54717.1 - 0.06 13.4 0.5 0.099 12.7 0.5 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain JIP_LZII PF16471.5 PIK54717.1 - 0.076 13.2 0.9 0.076 13.2 0.9 3.7 2 2 1 3 3 3 0 JNK-interacting protein leucine zipper II ABC_tran_CTD PF16326.5 PIK54717.1 - 0.13 12.5 6.5 1 9.6 0.7 3.3 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF5333 PF17267.2 PIK54717.1 - 0.14 12.3 4.2 0.25 11.5 1.5 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5333) Cnn_1N PF07989.11 PIK54717.1 - 0.39 10.9 11.4 0.045 13.9 3.1 2.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 TryThrA_C PF12319.8 PIK54717.1 - 1.6 8.2 9.6 0.046 13.2 2.4 2.0 2 0 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal ZapB PF06005.12 PIK54717.1 - 1.8 9.1 10.2 0.37 11.3 3.8 2.5 2 0 0 2 2 2 0 Cell division protein ZapB DUF16 PF01519.16 PIK54717.1 - 2 9.0 15.4 0.35 11.4 5.7 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 YabA PF06156.13 PIK54717.1 - 3.7 8.2 10.2 0.88 10.2 4.4 2.4 2 0 0 2 2 2 0 Initiation control protein YabA DUF2203 PF09969.9 PIK54717.1 - 4.4 8.1 6.9 7.3 7.3 1.8 2.6 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) LUC7 PF03194.15 PIK54717.1 - 7.2 6.2 14.9 1 9.0 6.9 2.1 1 1 0 2 2 2 0 LUC7 N_terminus Exonuc_VII_L PF02601.15 PIK54717.1 - 9.8 5.6 10.1 26 4.3 10.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 PIK54718.1 - 3.9e-112 375.8 5.8 4.6e-112 375.5 5.8 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein IPTL-CTERM PF18203.1 PIK54718.1 - 0.071 13.0 0.7 0.16 11.9 0.7 1.6 1 0 0 1 1 1 0 IPTL-CTERM motif DUF872 PF05915.12 PIK54718.1 - 0.095 12.9 4.5 0.5 10.6 2.4 2.9 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF3119 PF11317.8 PIK54718.1 - 0.22 11.8 2.1 0.26 11.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3119) TraL PF07178.11 PIK54718.1 - 1.4 9.5 6.4 1.5 9.3 0.1 2.6 2 1 0 2 2 2 0 TraL protein DUF2654 PF10849.8 PIK54720.1 - 0.054 13.7 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) DUF1759 PF03564.15 PIK54721.1 - 1.2e-07 31.8 0.8 2.1e-07 31.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK54721.1 - 0.22 12.1 3.0 0.31 11.6 0.1 2.5 3 0 0 3 3 3 0 Tis11B like protein, N terminus NUDE_C PF04880.13 PIK54721.1 - 1.2 9.6 8.6 0.58 10.6 5.3 2.2 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Exo_endo_phos_2 PF14529.6 PIK54722.1 - 1.2e-06 28.4 1.8 2.6e-06 27.3 0.3 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK54722.1 - 0.00044 19.8 0.0 0.002 17.7 0.0 1.9 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_S17 PF00366.20 PIK54724.1 - 6.9e-27 93.4 0.6 1.3e-26 92.4 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.5 PIK54724.1 - 4.5e-17 62.2 0.2 1.1e-16 61.0 0.1 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Exo_endo_phos_2 PF14529.6 PIK54725.1 - 1.4e-14 53.9 0.0 3.3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK54725.1 - 5e-06 26.2 0.6 1e-05 25.2 0.5 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PhageMin_Tail PF10145.9 PIK54729.1 - 0.096 12.5 0.2 0.14 12.0 0.2 1.2 1 0 0 1 1 1 0 Phage-related minor tail protein COMP PF11598.8 PIK54731.1 - 0.87 10.1 5.8 4 8.0 0.4 3.0 2 1 0 2 2 2 0 Cartilage oligomeric matrix protein Integrase_H2C2 PF17921.1 PIK54732.1 - 3.1e-18 65.6 0.7 4.5e-18 65.1 0.7 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK54732.1 - 0.00032 20.9 0.2 0.00055 20.1 0.2 1.4 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 PIK54732.1 - 0.011 15.9 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain PNMA PF14893.6 PIK54733.1 - 0.0065 15.9 0.0 0.011 15.1 0.0 1.3 1 1 0 1 1 1 1 PNMA Integrase_H2C2 PF17921.1 PIK54734.1 - 3.5e-23 81.5 0.0 9.2e-23 80.1 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK54734.1 - 2.8e-22 79.1 0.0 6.7e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK54734.1 - 2.8e-05 24.2 0.0 7.7e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK54734.1 - 6.2e-05 22.7 1.3 7.7e-05 22.4 0.3 1.7 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK54734.1 - 0.026 14.0 0.1 0.048 13.2 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK54738.1 - 3.1e-16 59.8 0.0 7.6e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK54738.1 - 0.00033 21.0 0.0 0.00075 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 PIK54738.1 - 0.004 16.7 0.0 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK54738.1 - 0.12 12.8 0.0 3 8.3 0.0 2.6 2 0 0 2 2 2 0 RNA helicase V-set PF07686.17 PIK54739.1 - 5.2e-05 23.4 0.2 0.00045 20.4 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK54739.1 - 0.015 15.4 0.3 3.2 8.0 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK54739.1 - 0.027 14.5 0.3 0.083 13.0 0.3 1.9 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK54739.1 - 0.045 14.1 1.6 0.079 13.3 0.3 2.1 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ribonuc_red_2_N PF08471.10 PIK54740.1 - 0.15 12.2 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase PP1_bind PF15276.6 PIK54740.1 - 2.1 8.7 8.0 0.43 10.9 0.4 3.1 1 1 3 4 4 4 0 Protein phosphatase 1 binding PRKCSH PF07915.13 PIK54741.1 - 3.2e-11 44.1 0.4 6.6e-11 43.1 0.4 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 PIK54741.1 - 0.025 14.3 0.1 0.045 13.4 0.1 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein B56 PF01603.20 PIK54742.1 - 1.3e-189 630.5 2.0 1.6e-189 630.2 2.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 PIK54742.1 - 0.0039 17.1 2.1 0.77 9.6 0.5 2.5 1 1 1 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal RB_B PF01857.20 PIK54742.1 - 0.068 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain DUF349 PF03993.12 PIK54742.1 - 0.11 12.8 4.2 0.21 11.9 4.2 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Thioredoxin PF00085.20 PIK54743.1 - 7.3e-16 58.0 0.0 1.2e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin FAM176 PF14851.6 PIK54743.1 - 0.022 14.4 0.1 0.088 12.5 0.1 1.9 1 1 0 1 1 1 0 FAM176 family Thioredoxin_9 PF14595.6 PIK54743.1 - 0.18 11.6 0.2 0.18 11.6 0.2 1.9 3 0 0 3 3 3 0 Thioredoxin SNF2_N PF00176.23 PIK54744.1 - 2.5e-65 220.5 1.3 2.5e-65 220.5 1.3 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 PIK54744.1 - 8.8e-47 158.8 20.0 8.8e-47 158.8 20.0 2.6 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 PIK54744.1 - 5.7e-17 62.1 0.0 1.5e-16 60.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK54744.1 - 0.00012 22.2 0.1 0.00082 19.4 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 PIK54744.1 - 0.0019 17.4 0.0 0.0019 17.4 0.0 3.5 4 0 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 L51_S25_CI-B8 PF05047.16 PIK54744.1 - 0.11 12.4 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ChaC PF04752.12 PIK54745.1 - 8e-55 185.7 0.0 9.9e-55 185.4 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein EGF PF00008.27 PIK54746.1 - 1.9e-23 82.4 38.0 1e-08 35.3 6.6 3.6 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK54746.1 - 5.5e-14 52.2 33.6 2.7e-05 24.6 7.1 3.9 3 0 0 3 3 3 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK54746.1 - 2.5e-07 31.0 47.3 0.0077 16.6 9.2 3.6 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 PIK54746.1 - 5.2e-05 23.4 41.0 0.28 11.4 9.1 3.8 1 1 2 3 3 3 2 Calcium-binding EGF domain DUF918 PF06033.11 PIK54746.1 - 0.001 19.1 0.6 0.0018 18.3 0.6 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF918) FXa_inhibition PF14670.6 PIK54746.1 - 0.024 14.9 33.0 0.2 12.0 5.8 3.8 1 1 2 3 3 3 0 Coagulation Factor Xa inhibitory site DUF1774 PF08611.10 PIK54746.1 - 0.052 13.9 0.0 0.088 13.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) EphA2_TM PF14575.6 PIK54746.1 - 0.068 14.0 0.1 0.14 13.1 0.1 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Metallothi_Euk2 PF12809.7 PIK54746.1 - 2.1 8.7 32.3 1.3 9.3 5.2 2.9 2 0 0 2 2 2 0 Eukaryotic metallothionein MNNL PF07657.13 PIK54747.1 - 2.5e-21 75.5 2.5 2.5e-21 75.5 2.5 3.2 3 0 0 3 3 3 1 N terminus of Notch ligand DSL PF01414.19 PIK54747.1 - 1.8e-19 69.7 7.9 1.8e-19 69.7 7.9 4.6 5 0 0 5 5 5 1 Delta serrate ligand EGF PF00008.27 PIK54747.1 - 5.9e-08 32.9 14.3 2.6e-07 30.8 8.2 7.2 5 1 1 6 6 6 3 EGF-like domain EGF_2 PF07974.13 PIK54747.1 - 0.0043 17.4 12.0 0.0043 17.4 12.0 7.5 6 1 1 7 7 7 3 EGF-like domain hEGF PF12661.7 PIK54747.1 - 5.2 7.9 68.8 0.06 14.0 5.5 8.6 9 0 0 9 9 9 0 Human growth factor-like EGF NIF PF03031.18 PIK54748.1 - 1.6e-37 128.7 0.0 2.4e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase CrgA PF06781.12 PIK54748.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Cell division protein CrgA RRM_1 PF00076.22 PIK54749.1 - 2.2e-30 104.2 0.5 1.3e-15 57.0 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK54749.1 - 4.2e-06 26.7 0.5 0.0003 20.8 0.1 2.3 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.8 PIK54749.1 - 0.00062 19.8 0.7 0.21 11.7 0.1 2.5 2 0 0 2 2 2 2 Limkain b1 RRM_5 PF13893.6 PIK54749.1 - 0.00092 18.8 0.0 0.95 9.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK54749.1 - 0.0025 17.6 0.0 0.52 10.2 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RSRP PF17069.5 PIK54749.1 - 0.094 12.3 54.5 0.13 11.8 54.5 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Nup35_RRM_2 PF14605.6 PIK54749.1 - 0.11 12.5 0.0 0.54 10.3 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 PIK54750.1 - 7.5e-24 83.4 0.9 3.1e-14 52.5 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK54750.1 - 2.4e-06 27.2 0.0 0.051 13.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK54750.1 - 0.001 19.1 0.6 0.029 14.4 0.2 2.5 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.8 PIK54750.1 - 0.0013 18.7 1.2 0.61 10.2 0.2 2.4 2 0 0 2 2 2 2 Limkain b1 RSRP PF17069.5 PIK54750.1 - 0.0059 16.2 73.1 0.0094 15.6 73.1 1.3 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 RRM_occluded PF16842.5 PIK54750.1 - 0.051 13.4 0.0 3.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 PIK54750.1 - 0.051 13.6 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Spc7_N PF15402.6 PIK54750.1 - 0.16 10.2 30.7 0.21 9.8 30.7 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Macoilin PF09726.9 PIK54750.1 - 0.46 9.0 18.8 0.5 8.8 18.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF572 PF04502.13 PIK54750.1 - 1.9 8.0 25.5 2.4 7.7 25.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) XRN_M PF17846.1 PIK54750.1 - 9.4 5.1 9.0 13 4.6 9.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain LSM PF01423.22 PIK54751.1 - 3.2e-19 68.4 0.4 4.6e-19 67.9 0.4 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 PIK54751.1 - 0.018 14.7 0.1 0.033 13.8 0.1 1.4 1 0 0 1 1 1 0 Hfq protein DUF2986 PF11661.8 PIK54751.1 - 0.19 12.3 1.0 0.19 12.3 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) DUF4515 PF14988.6 PIK54752.1 - 6.9e-19 68.5 41.2 6.9e-19 68.5 41.2 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4515) PCP PF02429.15 PIK54752.1 - 0.046 14.0 0.1 0.28 11.5 0.0 2.3 2 0 0 2 2 2 0 Peridinin-chlorophyll A binding protein DUF3573 PF12097.8 PIK54752.1 - 1.6 7.5 14.0 0.077 11.8 7.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3573) 2OG-FeII_Oxy_2 PF13532.6 PIK54753.1 - 2.7e-23 83.2 0.1 4.4e-22 79.2 0.0 2.6 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Cyclin_N PF00134.23 PIK54754.1 - 1e-07 31.7 0.0 3.3e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK54754.1 - 0.0088 16.1 0.2 0.017 15.2 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 PIK54754.1 - 0.025 14.9 0.0 0.055 13.9 0.0 1.5 1 1 0 1 1 1 0 Cyclin C-terminal domain TPR_2 PF07719.17 PIK54755.1 - 1.9e-18 65.0 0.3 0.00015 21.6 0.2 6.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK54755.1 - 4.6e-18 64.2 0.4 0.00015 21.4 0.3 6.3 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK54755.1 - 3.8e-15 54.8 0.0 9.2e-05 22.4 0.1 5.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK54755.1 - 8.1e-15 54.2 2.9 0.0022 17.7 0.1 6.2 2 1 4 6 6 6 5 TPR repeat TPR_9 PF13371.6 PIK54755.1 - 9.4e-11 41.7 0.0 1.3e-07 31.6 0.0 3.9 2 2 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK54755.1 - 1.3e-09 38.1 0.3 0.022 15.5 0.1 5.7 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK54755.1 - 3.9e-09 37.0 0.3 3.3e-05 24.4 0.0 4.4 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK54755.1 - 1.2e-08 35.3 0.1 5.2e-06 26.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK54755.1 - 4.4e-08 33.3 0.2 1.4e-06 28.5 0.0 3.5 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK54755.1 - 4.8e-08 33.1 0.0 1.3 9.8 0.1 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK54755.1 - 1.5e-06 28.3 1.1 0.0012 19.0 0.0 3.6 2 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 PIK54755.1 - 1.1e-05 25.2 1.7 0.00024 20.9 0.3 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK54755.1 - 2.3e-05 23.5 0.1 0.00031 19.8 0.0 2.3 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 PIK54755.1 - 9.3e-05 22.5 0.3 0.019 15.3 0.1 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK54755.1 - 0.00027 20.7 0.5 0.0073 16.2 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 PIK54755.1 - 0.00086 19.0 2.5 0.077 12.6 0.1 3.3 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_20 PF14561.6 PIK54755.1 - 0.0025 18.1 0.4 3.7 7.9 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK54755.1 - 0.026 13.5 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF3577 PF12101.8 PIK54755.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3577) SKIP_SNW PF02731.15 PIK54757.1 - 4.9e-40 136.8 21.1 1.2e-34 119.3 5.3 2.6 1 1 1 2 2 2 2 SKIP/SNW domain ABC1 PF03109.16 PIK54758.1 - 9.1e-38 129.1 0.1 1.9e-37 128.1 0.1 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 PIK54758.1 - 1.6e-05 24.4 0.1 0.00083 18.8 0.1 2.5 2 1 0 3 3 3 1 Protein kinase domain APH PF01636.23 PIK54758.1 - 0.032 14.2 0.2 0.58 10.0 0.4 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family ThiF PF00899.21 PIK54759.1 - 1.9e-26 92.9 0.1 2.5e-26 92.5 0.1 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 PIK54759.1 - 0.0027 17.3 0.1 0.0042 16.7 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 PIK54759.1 - 0.12 11.6 0.2 0.15 11.2 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 PIK54760.1 - 1.3e-23 83.6 0.0 2.1e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 PIK54760.1 - 2.7e-07 31.1 0.0 4.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain IHO1 PF15771.5 PIK54761.1 - 0.06 12.1 0.1 0.06 12.1 0.1 1.0 1 0 0 1 1 1 0 Interactor of HORMAD1 protein 1 RRM_1 PF00076.22 PIK54762.1 - 6.7e-28 96.3 1.7 3.5e-13 49.1 0.1 3.2 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK54762.1 - 2.4e-09 36.8 0.0 0.0017 17.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK54762.1 - 6.6e-08 32.3 0.0 0.00025 20.9 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF4523 PF15023.6 PIK54762.1 - 0.011 15.5 0.2 0.039 13.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Ribosomal_L32e PF01655.18 PIK54763.1 - 7e-51 171.2 3.5 8.4e-51 170.9 3.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 AAA PF00004.29 PIK54764.1 - 2.7e-41 141.1 0.3 6.3e-41 139.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 PIK54764.1 - 2.2e-08 33.9 0.0 5.7e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 PIK54764.1 - 3.3e-06 27.6 0.4 0.00046 20.6 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK54764.1 - 9e-06 25.7 1.5 7e-05 22.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 PIK54764.1 - 8e-05 22.4 0.1 0.0002 21.2 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK54764.1 - 0.00012 22.3 0.5 0.021 15.1 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK54764.1 - 0.00021 21.5 0.4 0.0022 18.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 PIK54764.1 - 0.0012 18.1 0.0 0.0021 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) JIP_LZII PF16471.5 PIK54764.1 - 0.0021 18.2 4.7 0.0063 16.7 4.7 1.8 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II PhoH PF02562.16 PIK54764.1 - 0.0029 17.1 0.0 0.027 13.9 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 PIK54764.1 - 0.0081 15.6 0.1 0.022 14.2 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 PIK54764.1 - 0.012 15.4 0.2 0.69 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 PIK54764.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 PIK54764.1 - 0.013 14.8 0.4 0.079 12.3 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 PIK54764.1 - 0.016 15.3 0.1 0.048 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 PIK54764.1 - 0.024 14.4 0.2 0.08 12.7 0.2 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 PIK54764.1 - 0.043 13.5 0.0 0.21 11.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 PIK54764.1 - 0.046 14.3 0.3 0.14 12.7 0.0 2.1 2 2 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK54764.1 - 0.049 13.1 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 PIK54764.1 - 0.067 12.8 0.6 0.27 10.8 0.2 2.0 1 1 1 2 2 2 0 AAA domain DUF3713 PF12506.8 PIK54764.1 - 0.095 13.0 0.1 0.82 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) RNA_helicase PF00910.22 PIK54764.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 PIK54764.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 PIK54764.1 - 0.13 12.5 0.4 0.52 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PHD PF00628.29 PIK54766.1 - 4.7e-10 39.2 9.9 6.7e-10 38.7 9.9 1.2 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 PIK54766.1 - 0.00045 20.0 8.0 0.00049 19.9 3.1 2.2 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 PIK54766.1 - 0.00049 19.8 6.7 0.0029 17.3 2.9 2.0 1 1 1 2 2 2 1 PHD/FYVE-zinc-finger like domain zf-HC5HC2H_2 PF13832.6 PIK54766.1 - 0.0023 18.1 3.9 0.0032 17.6 3.9 1.2 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD_4 PF16866.5 PIK54766.1 - 0.0042 17.1 8.7 0.01 15.9 8.7 1.7 1 1 0 1 1 1 1 PHD-finger zf-RING_9 PF13901.6 PIK54766.1 - 0.014 15.4 5.6 0.021 14.8 5.6 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.6 PIK54766.1 - 0.015 14.8 3.9 0.015 14.8 3.9 2.0 2 0 0 2 2 2 0 PHD-finger zinc_ribbon_15 PF17032.5 PIK54766.1 - 0.03 15.1 3.3 0.051 14.3 3.3 1.4 1 0 0 1 1 1 0 zinc-ribbon family Prok-RING_1 PF14446.6 PIK54766.1 - 0.096 12.6 6.8 0.057 13.4 3.0 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 PIK54766.1 - 6.1 6.5 10.6 2.7 7.7 6.4 2.0 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 PIK54766.1 - 6.3 7.0 10.1 28 4.9 10.1 2.0 1 1 0 1 1 1 0 KIAA1045 RING finger JmjC PF02373.22 PIK54767.1 - 1.2e-11 45.1 0.1 5.3e-07 30.1 0.0 2.7 2 0 0 2 2 2 2 JmjC domain, hydroxylase Cupin_8 PF13621.6 PIK54767.1 - 1e-06 28.7 1.3 0.0074 16.0 0.1 3.0 1 1 1 2 2 2 2 Cupin-like domain SR-25 PF10500.9 PIK54767.1 - 0.0053 16.4 11.0 0.0082 15.8 11.0 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 PIK54767.1 - 0.12 10.4 12.1 0.16 10.0 12.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF913 PF06025.12 PIK54767.1 - 0.29 10.1 1.0 0.4 9.6 1.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4614 PF15391.6 PIK54767.1 - 1.1 9.2 6.1 1.8 8.5 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) FAM163 PF15069.6 PIK54768.1 - 0.012 16.1 0.0 0.012 16.1 0.0 1.9 2 0 0 2 2 2 0 FAM163 family DuoxA PF10204.9 PIK54768.1 - 3.2 6.7 6.7 1.2 8.1 4.4 1.5 1 1 0 1 1 1 0 Dual oxidase maturation factor Ninjurin PF04923.12 PIK54769.1 - 0.047 13.6 1.8 0.093 12.7 0.4 1.9 1 1 1 2 2 2 0 Ninjurin Orai-1 PF07856.12 PIK54769.1 - 0.25 11.0 2.9 0.27 10.9 0.4 2.1 1 1 1 2 2 2 0 Mediator of CRAC channel activity zf-H2C2_5 PF13909.6 PIK54770.1 - 7e-22 76.8 27.6 1.8e-07 30.8 1.4 4.3 4 0 0 4 4 4 4 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK54770.1 - 8.1e-11 41.8 25.6 1.4e-05 25.3 0.3 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54770.1 - 3.8e-08 33.5 22.9 0.0091 16.8 0.6 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK54770.1 - 1.1e-07 31.9 26.1 0.0033 17.8 0.8 4.7 4 1 0 4 4 4 3 Zinc finger, C2H2 type OrsD PF12013.8 PIK54770.1 - 0.00026 21.4 17.2 0.26 11.7 0.0 4.3 2 2 2 4 4 4 2 Orsellinic acid/F9775 biosynthesis cluster protein D AKAP95 PF04988.12 PIK54770.1 - 0.04 14.1 16.4 1.3 9.3 0.3 4.0 4 0 0 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) zf-C2HE PF16278.5 PIK54770.1 - 0.069 13.6 17.0 0.84 10.1 0.0 4.2 2 2 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4219 PF13961.6 PIK54770.1 - 0.13 11.9 0.4 0.28 10.9 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-C2H2_jaz PF12171.8 PIK54770.1 - 0.25 11.7 0.3 0.25 11.7 0.3 4.8 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK54770.1 - 0.44 10.3 0.1 0.44 10.3 0.1 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type Cys_rich_CPCC PF14206.6 PIK54770.1 - 0.68 9.8 6.9 21 5.0 0.6 3.5 3 1 0 3 3 3 0 Cysteine-rich CPCC zf-ZPR1 PF03367.13 PIK54770.1 - 0.83 9.5 7.3 2.2 8.1 3.6 2.4 2 0 0 2 2 2 0 ZPR1 zinc-finger domain zf_C2H2_ZHX PF18387.1 PIK54770.1 - 1.5 8.6 14.4 5.8 6.6 4.6 3.5 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain PHD_4 PF16866.5 PIK54770.1 - 3.2 7.9 6.2 1.1 9.4 1.0 2.4 2 0 0 2 2 2 0 PHD-finger zinc_ribbon_15 PF17032.5 PIK54770.1 - 4.8 8.0 10.5 5.1 7.9 1.4 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_2 PF12756.7 PIK54770.1 - 5.4 7.4 17.9 12 6.3 0.2 3.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 PIK54770.1 - 9.3 6.4 20.8 11 6.1 3.4 3.6 1 1 1 2 2 2 0 BED zinc finger zf-H2C2_5 PF13909.6 PIK54771.1 - 2e-20 72.2 70.0 5.6e-07 29.2 3.2 6.8 7 0 0 7 7 7 5 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK54771.1 - 3e-14 52.7 53.1 0.0001 22.6 4.0 7.4 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK54771.1 - 2e-10 40.5 72.3 0.00021 21.6 5.8 7.2 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK54771.1 - 5.9e-06 26.7 61.0 0.037 14.9 3.2 6.8 7 0 0 7 7 7 5 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 PIK54771.1 - 0.18 11.5 43.5 0.79 9.4 0.7 7.2 4 3 4 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain Cobl PF09469.10 PIK54771.1 - 4.7 7.6 8.2 9.1 6.6 0.0 3.9 1 1 3 5 5 5 0 Cordon-bleu ubiquitin-like domain TAF6_C PF07571.13 PIK54772.1 - 4.2e-29 100.7 0.0 8.4e-29 99.7 0.0 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 PIK54772.1 - 3.2e-22 78.5 0.1 8.3e-22 77.1 0.1 1.8 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) CAP_N PF01213.19 PIK54772.1 - 0.066 12.7 1.2 0.28 10.6 0.9 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Angiomotin_C PF12240.8 PIK54773.1 - 1.2e-26 93.5 38.6 3.1e-26 92.2 18.2 3.4 2 2 0 2 2 2 2 Angiomotin C terminal bZIP_1 PF00170.21 PIK54773.1 - 0.022 14.8 0.4 0.022 14.8 0.4 5.6 5 1 0 5 5 5 0 bZIP transcription factor DUF4407 PF14362.6 PIK54773.1 - 1.3 8.3 29.2 1.5 8.1 8.3 4.2 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) DUF4465 PF14717.6 PIK54774.1 - 0.14 12.6 1.5 0.27 11.6 1.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4465) Sulfotransfer_1 PF00685.27 PIK54775.1 - 5.1e-14 52.4 0.0 1.4e-13 50.9 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK54775.1 - 9.4e-09 36.0 0.4 3.2e-07 31.0 0.4 3.0 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK54775.1 - 0.05 13.5 3.2 0.69 9.8 0.0 3.1 3 0 0 3 3 3 0 Sulfotransferase family MFS_1 PF07690.16 PIK54776.1 - 3.2e-35 121.7 33.3 2.2e-24 86.1 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK54776.1 - 2.9e-09 36.3 0.0 0.001 18.0 0.0 2.5 1 1 1 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 PIK54776.1 - 0.15 10.4 9.2 0.16 10.3 2.8 2.4 2 0 0 2 2 2 0 Transmembrane secretion effector MFS_1 PF07690.16 PIK54777.1 - 5.3e-19 68.3 20.4 2.5e-18 66.1 19.7 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyco_transf_10 PF00852.19 PIK54778.1 - 3.4e-52 176.7 0.9 5e-52 176.2 0.9 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK54778.1 - 2.5e-11 44.0 0.2 4.7e-11 43.1 0.2 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Nuc_sug_transp PF04142.15 PIK54779.1 - 2.3e-44 151.9 16.0 2.9e-44 151.5 16.0 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter Chordopox_A30L PF06015.12 PIK54779.1 - 0.087 12.7 0.2 0.19 11.6 0.2 1.5 1 0 0 1 1 1 0 Chordopoxvirus A30L protein EamA PF00892.20 PIK54779.1 - 0.25 11.5 27.8 0.6 10.3 12.3 2.4 2 1 0 2 2 2 0 EamA-like transporter family Glyco_transf_15 PF01793.16 PIK54780.1 - 0.0053 16.1 0.0 0.007 15.7 0.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TIR_2 PF13676.6 PIK54781.1 - 2.8e-13 50.5 0.0 4.5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 PIK54781.1 - 3.2e-12 46.6 0.0 6.4e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain I-set PF07679.16 PIK54781.1 - 4.7e-07 29.8 1.3 0.0017 18.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54781.1 - 5.6e-06 26.9 4.7 0.017 15.7 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK54781.1 - 0.018 15.4 0.6 0.018 15.4 0.6 2.8 2 1 0 2 2 2 0 Immunoglobulin domain DUF5074 PF16819.5 PIK54781.1 - 0.12 12.5 0.4 11 6.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) Elf1 PF05129.13 PIK54781.1 - 0.15 12.1 5.2 5.4 7.1 0.1 3.4 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like V-set PF07686.17 PIK54781.1 - 1.2 9.4 10.1 0.039 14.1 2.2 2.6 3 1 0 3 3 3 0 Immunoglobulin V-set domain Lamp PF01299.17 PIK54782.1 - 1.5e-05 24.9 0.0 2.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 PIK54782.1 - 5.8e-05 23.0 0.1 8.5e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) AMA-1 PF02430.15 PIK54782.1 - 0.025 13.6 0.1 0.047 12.7 0.1 1.5 1 1 0 1 1 1 0 Apical membrane antigen 1 DUF4912 PF16258.5 PIK54782.1 - 0.046 13.9 0.0 0.077 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4912) SBP_bac_8 PF13416.6 PIK54782.1 - 0.05 13.4 0.1 0.058 13.2 0.1 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Amnionless PF14828.6 PIK54782.1 - 0.15 10.8 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless TIR PF01582.20 PIK54783.1 - 2.1e-12 47.2 0.2 2.8e-12 46.8 0.2 1.3 1 1 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK54783.1 - 1.5e-11 45.0 0.0 1.7e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 TIR domain Gemini_V2 PF01524.17 PIK54783.1 - 0.16 12.2 0.0 0.44 10.8 0.0 1.7 2 0 0 2 2 2 0 Geminivirus V2 protein TPR_14 PF13428.6 PIK54785.1 - 7.1e-07 29.5 0.3 1.3 10.0 0.0 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK54785.1 - 1.9e-06 27.4 0.7 5.1e-05 22.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK54785.1 - 6e-05 22.9 4.1 0.00045 20.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK54785.1 - 0.00011 22.7 0.2 0.0097 16.5 0.0 3.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK54785.1 - 0.0035 17.8 0.9 4.7 7.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK54785.1 - 0.0039 17.1 0.8 0.049 13.7 0.0 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK54785.1 - 0.0071 16.0 0.0 0.18 11.5 0.0 2.7 1 1 1 2 2 2 1 TPR repeat TPR_8 PF13181.6 PIK54785.1 - 0.0086 16.2 0.1 0.0086 16.2 0.1 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK54785.1 - 0.04 13.1 1.0 0.44 9.7 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK54785.1 - 0.069 13.6 0.1 8.2 7.1 0.0 3.6 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK54785.1 - 0.21 11.9 0.1 0.21 11.9 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK54785.1 - 0.63 10.8 2.4 4.5 8.1 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF948 PF06103.11 PIK54786.1 - 0.11 12.8 2.3 4.4 7.6 0.6 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RYDR_ITPR PF01365.21 PIK54786.1 - 0.24 10.8 5.7 0.35 10.2 5.7 1.3 1 0 0 1 1 1 0 RIH domain LMBR1 PF04791.16 PIK54786.1 - 1.4 7.7 5.3 1.1 8.1 4.4 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein MIIP PF15734.5 PIK54787.1 - 0.034 13.6 0.3 0.042 13.3 0.3 1.2 1 0 0 1 1 1 0 Migration and invasion-inhibitory RVT_N PF13655.6 PIK54787.1 - 0.035 14.4 0.1 0.051 13.8 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of reverse transcriptase Ran_BP1 PF00638.18 PIK54788.1 - 8.5e-98 323.1 7.4 3.6e-49 166.1 0.3 2.6 2 0 0 2 2 2 2 RanBP1 domain zf-RanBP PF00641.18 PIK54788.1 - 4.2e-09 35.6 3.0 8e-09 34.7 3.0 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others WH1 PF00568.23 PIK54788.1 - 3.7e-05 23.6 3.0 0.11 12.4 0.3 2.7 3 0 0 3 3 3 2 WH1 domain IR1-M PF12185.8 PIK54788.1 - 0.0039 17.1 0.1 0.0039 17.1 0.1 3.5 4 0 0 4 4 4 1 Nup358/RanBP2 E3 ligase domain DUF3439 PF11921.8 PIK54788.1 - 1.6 8.7 11.3 6.9 6.7 11.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Na_H_Exchanger PF00999.21 PIK54790.1 - 9.9e-37 126.6 18.2 2e-18 66.4 1.7 2.0 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family Pkr1 PF08636.10 PIK54791.1 - 0.0075 16.4 2.7 0.013 15.6 2.7 1.5 1 0 0 1 1 1 1 ER protein Pkr1 Pyocin_S PF06958.12 PIK54791.1 - 0.016 15.8 2.3 0.028 15.0 2.3 1.4 1 0 0 1 1 1 0 S-type Pyocin Na_H_Exchanger PF00999.21 PIK54791.1 - 0.02 13.7 0.3 0.027 13.2 0.3 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family DUF2157 PF09925.9 PIK54791.1 - 0.031 14.1 0.9 0.046 13.5 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Sid-5 PF17204.3 PIK54791.1 - 0.089 13.0 0.6 0.15 12.2 0.6 1.4 1 0 0 1 1 1 0 Sid-5 family DUF4131 PF13567.6 PIK54791.1 - 0.12 12.0 0.2 0.2 11.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) NAD_binding_8 PF13450.6 PIK54792.1 - 3.1e-11 43.3 0.0 5.4e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK54792.1 - 1.2e-05 25.0 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 PIK54792.1 - 1.3e-05 24.7 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 PIK54792.1 - 0.00037 20.5 0.1 0.001 19.1 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding MCRA PF06100.11 PIK54792.1 - 0.00086 18.2 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 MCRA family Pyr_redox_2 PF07992.14 PIK54792.1 - 0.001 18.4 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK54792.1 - 0.0051 16.1 0.0 0.0081 15.4 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 PIK54792.1 - 0.0086 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK54792.1 - 0.052 12.6 0.0 0.074 12.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 PIK54792.1 - 0.084 12.2 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase K_oxygenase PF13434.6 PIK54792.1 - 0.086 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 PIK54792.1 - 0.09 13.3 0.0 0.25 11.9 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK54792.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 PIK54792.1 - 0.21 10.2 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Rotamase_3 PF13616.6 PIK54793.1 - 7.3e-20 71.7 0.1 2e-19 70.2 0.1 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 PIK54793.1 - 2.5e-15 57.2 0.0 4.8e-15 56.3 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 PIK54793.1 - 0.024 15.5 0.0 0.039 14.8 0.0 1.4 1 1 0 1 1 1 0 PPIC-type PPIASE domain AMMECR1 PF01871.17 PIK54794.1 - 9e-50 168.5 0.0 1.2e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 EMP70 PF02990.16 PIK54795.1 - 9.1e-172 572.3 25.8 7.1e-89 298.8 0.1 2.5 2 1 1 3 3 3 2 Endomembrane protein 70 FtsH_ext PF06480.15 PIK54795.1 - 6 7.3 6.7 19 5.6 2.2 3.1 2 1 1 3 3 3 0 FtsH Extracellular DUF423 PF04241.15 PIK54796.1 - 2.1e-17 63.1 1.0 3.3e-17 62.5 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Deltameth_res PF16020.5 PIK54796.1 - 0.36 10.7 0.2 0.36 10.7 0.2 1.8 2 0 0 2 2 2 0 Deltamethrin resistance fn3 PF00041.21 PIK54797.1 - 1.4e-75 249.6 0.1 2e-12 47.3 0.0 8.0 7 1 0 7 7 7 7 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK54797.1 - 2.8e-20 72.7 0.2 0.0051 17.3 0.1 8.0 7 2 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK54797.1 - 5.4e-08 33.1 0.2 0.0033 17.7 0.0 5.3 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 PIK54797.1 - 1.2e-07 32.0 0.0 5.9 7.4 0.0 5.9 6 1 0 6 6 6 3 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.5 PIK54797.1 - 0.024 14.5 0.0 37 4.3 0.0 5.4 8 0 0 8 8 8 0 Fibronectin-III type domain Suf PF05843.14 PIK54797.1 - 0.8 9.6 2.8 1.4 8.8 2.8 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ran_BP1 PF00638.18 PIK54798.1 - 3.4e-24 85.4 11.9 5.8e-11 42.7 0.6 3.9 3 0 0 3 3 3 3 RanBP1 domain VID27_PH PF17747.1 PIK54798.1 - 7e-05 23.1 5.8 0.78 10.0 0.1 3.4 3 0 0 3 3 3 2 VID27 PH-like domain ACI44 PF15270.6 PIK54798.1 - 0.0022 18.2 0.3 5.1 7.4 0.0 3.0 2 1 1 3 3 3 2 Metallo-carboxypeptidase inhibitor YcgR_2 PF12945.7 PIK54798.1 - 0.014 15.5 0.1 7.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Flagellar protein YcgR BRAP2 PF07576.12 PIK54798.1 - 0.86 9.9 6.9 33 4.8 0.2 3.3 3 0 0 3 3 3 0 BRCA1-associated protein 2 RTX_C PF08339.10 PIK54799.1 - 0.27 11.3 5.5 1.2 9.1 0.9 2.7 1 1 1 2 2 2 0 RTX C-terminal domain DUF2922 PF11148.8 PIK54799.1 - 0.49 10.2 6.2 12 5.7 0.8 4.6 1 1 4 5 5 5 0 Protein of unknown function (DUF2922) RVT_1 PF00078.27 PIK54800.1 - 2.5e-12 46.8 0.1 4.5e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EMP70 PF02990.16 PIK54801.1 - 1.5e-05 23.9 3.9 1.5e-05 23.9 3.9 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 DUF2178 PF09946.9 PIK54801.1 - 0.036 14.3 0.3 0.064 13.4 0.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) PHO4 PF01384.20 PIK54801.1 - 0.066 12.2 4.3 0.095 11.7 4.3 1.1 1 0 0 1 1 1 0 Phosphate transporter family Claudin_2 PF13903.6 PIK54801.1 - 2.8 7.6 9.8 0.3 10.8 4.2 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction FAM176 PF14851.6 PIK54801.1 - 3.5 7.3 12.4 0.11 12.2 1.6 3.3 3 1 0 3 3 3 0 FAM176 family DUF2721 PF11026.8 PIK54801.1 - 8 6.4 9.6 0.22 11.4 2.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) 7tm_1 PF00001.21 PIK54803.1 - 5e-42 144.1 11.3 6.2e-42 143.7 11.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK54803.1 - 1.2e-12 48.1 12.9 1.2e-12 48.1 12.9 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK54803.1 - 4.7e-11 42.6 12.7 1.1e-10 41.4 12.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK54803.1 - 3e-08 33.7 9.2 5.3e-05 23.1 7.7 2.8 2 1 0 2 2 2 2 Olfactory receptor GDPD PF03009.17 PIK54804.1 - 7.2e-16 58.7 0.1 9.7e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family RseC_MucC PF04246.12 PIK54804.1 - 1.3 9.0 3.0 0.64 10.0 0.5 1.7 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Renin_r PF07850.14 PIK54806.1 - 2.4e-24 85.8 0.4 4.2e-24 85.0 0.4 1.4 1 0 0 1 1 1 1 Renin receptor-like protein Phosphodiest PF01663.22 PIK54806.1 - 0.099 12.2 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF2474 PF10617.9 PIK54806.1 - 0.12 12.3 2.1 0.23 11.3 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) COG7 PF10191.9 PIK54807.1 - 3.3e-185 617.6 15.7 9.8e-103 344.9 0.0 2.0 1 1 1 2 2 2 2 Golgi complex component 7 (COG7) COG5 PF10392.9 PIK54807.1 - 2.5e-06 27.7 9.7 4.3e-06 26.9 4.8 3.1 3 0 0 3 3 3 1 Golgi transport complex subunit 5 MFS_1 PF07690.16 PIK54808.1 - 1.2e-29 103.3 12.9 5.3e-19 68.3 14.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK54808.1 - 0.0015 17.5 5.9 0.22 10.3 5.9 2.7 2 1 0 2 2 2 2 MFS_1 like family CLN3 PF02487.17 PIK54808.1 - 0.014 14.5 5.9 0.016 14.3 0.9 2.4 1 1 1 2 2 2 0 CLN3 protein DUF4691 PF15762.5 PIK54808.1 - 0.078 13.1 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) DUF2530 PF10745.9 PIK54808.1 - 1.2 9.4 8.7 0.2 11.9 1.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) MFS_1 PF07690.16 PIK54809.1 - 1.2e-14 54.0 19.7 1.5e-14 53.7 19.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK54809.1 - 0.00033 19.3 6.2 0.00045 18.9 6.2 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 PIK54809.1 - 0.049 12.5 10.2 0.03 13.2 8.5 1.4 1 1 0 1 1 1 0 Sugar (and other) transporter MFS_1_like PF12832.7 PIK54809.1 - 0.19 10.5 6.0 0.32 9.8 5.9 1.4 1 1 0 1 1 1 0 MFS_1 like family Fibrinogen_C PF00147.18 PIK54812.1 - 3.8e-30 105.3 0.8 2.2e-27 96.3 0.3 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Ndc1_Nup PF09531.10 PIK54812.1 - 0.36 9.5 1.0 0.59 8.8 1.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V-ATPase_H_C PF11698.8 PIK54813.1 - 0.049 13.8 0.0 0.067 13.3 0.0 1.1 1 0 0 1 1 1 0 V-ATPase subunit H HAD_2 PF13419.6 PIK54814.1 - 3.1e-25 89.3 0.0 3.6e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK54814.1 - 5.5e-18 66.0 0.0 8.9e-17 62.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK54814.1 - 1e-05 25.5 0.0 2.8e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 PIK54814.1 - 1.9e-05 25.1 0.0 2.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 PIK54814.1 - 2.4e-05 24.4 0.0 0.17 12.0 0.0 2.4 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Nkap_C PF06047.11 PIK54815.1 - 3.8e-48 161.8 0.9 3.8e-48 161.8 0.9 3.0 3 0 0 3 3 3 1 NF-kappa-B-activating protein C-terminal domain LRR_8 PF13855.6 PIK54816.1 - 0.06 13.1 0.6 0.21 11.4 0.5 1.9 1 1 1 2 2 2 0 Leucine rich repeat NACHT PF05729.12 PIK54817.1 - 2.2e-11 44.0 0.0 6.2e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK54817.1 - 1.8e-07 31.6 8.6 0.017 15.7 0.0 4.7 3 2 2 5 5 5 2 Immunoglobulin domain I-set PF07679.16 PIK54817.1 - 8.3e-06 25.8 1.5 0.051 13.6 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK54817.1 - 1.7e-05 24.9 4.8 0.0028 17.8 0.0 4.1 5 0 0 5 5 5 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK54817.1 - 0.00051 20.1 3.0 0.033 14.2 0.4 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain AAA_14 PF13173.6 PIK54817.1 - 0.00061 19.8 0.1 0.055 13.5 0.1 2.6 2 0 0 2 2 2 1 AAA domain C1-set PF07654.15 PIK54817.1 - 0.0034 17.7 0.8 1.2 9.6 0.2 2.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain AAA_16 PF13191.6 PIK54817.1 - 0.024 15.0 0.0 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain TniB PF05621.11 PIK54817.1 - 0.027 13.9 0.0 0.061 12.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 PIK54817.1 - 0.032 14.1 0.1 0.65 9.9 0.1 2.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Ntox46 PF15538.6 PIK54817.1 - 0.038 14.0 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 46 AAA_22 PF13401.6 PIK54817.1 - 0.12 12.6 0.9 2.4 8.4 0.0 3.0 3 1 0 3 3 3 0 AAA domain PRD1_DD PF11087.8 PIK54817.1 - 0.2 11.4 4.4 3.9 7.3 0.3 2.4 2 0 0 2 2 2 0 PRD1 phage membrane DNA delivery PLAT PF01477.23 PIK54821.1 - 8.6e-207 674.5 26.2 3.7e-24 85.5 0.0 10.1 10 0 0 10 10 10 10 PLAT/LH2 domain ATS3 PF06232.11 PIK54821.1 - 5.6e-17 61.8 0.0 0.074 13.0 0.0 8.0 9 0 0 9 9 9 6 Embryo-specific protein 3, (ATS3) Lactamase_B_5 PF14597.6 PIK54821.1 - 0.0082 15.7 2.7 28 4.1 0.0 5.6 7 0 0 7 7 7 1 Metallo-beta-lactamase superfamily RBFA PF02033.18 PIK54821.1 - 0.028 14.9 5.0 3.7 8.1 0.0 4.8 7 0 0 7 7 7 0 Ribosome-binding factor A Transthyretin PF00576.21 PIK54821.1 - 0.087 13.5 0.3 3 8.6 0.0 3.7 3 0 0 3 3 3 0 HIUase/Transthyretin family LnmK_N_HDF PF18238.1 PIK54821.1 - 0.15 11.8 0.1 65 3.2 0.0 3.9 5 0 0 5 5 5 0 LnmK N-terminal Hot Dog Fold domain PLAT PF01477.23 PIK54822.1 - 2.7e-20 73.1 0.1 2.4e-12 47.4 0.0 2.1 2 0 0 2 2 2 2 PLAT/LH2 domain PLAT PF01477.23 PIK54823.1 - 2.4e-43 147.4 1.2 1.1e-26 93.7 0.0 3.0 3 0 0 3 3 3 2 PLAT/LH2 domain Patched PF02460.18 PIK54824.1 - 1.4e-44 152.5 1.6 1.7e-44 152.1 1.6 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK54824.1 - 3.7e-23 82.1 4.5 3.7e-23 82.1 4.5 1.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation BPD_transp_2 PF02653.16 PIK54824.1 - 0.59 9.2 10.9 0.85 8.7 10.9 1.2 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF4064 PF13273.6 PIK54824.1 - 0.9 9.8 5.6 0.99 9.7 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) TssN PF17555.2 PIK54824.1 - 1.2 8.5 6.8 1.6 8.1 6.8 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN SecD_SecF PF02355.16 PIK54824.1 - 2.2 7.6 8.7 0.85 9.0 2.3 2.1 2 0 0 2 2 2 0 Protein export membrane protein CH PF00307.31 PIK54825.1 - 6.5e-20 71.3 0.2 1.3e-16 60.7 0.1 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK54825.1 - 0.0035 17.1 0.1 0.0086 15.9 0.1 1.7 2 0 0 2 2 2 1 CAMSAP CH domain Pol_alpha_B_N PF08418.10 PIK54825.1 - 0.16 11.9 0.0 0.24 11.4 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CH PF00307.31 PIK54826.1 - 1.2e-07 31.8 0.0 1.6e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain TP_methylase PF00590.20 PIK54826.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.0 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases zf-C2H2 PF00096.26 PIK54827.1 - 2.1e-24 84.6 78.4 0.0033 17.8 0.2 10.8 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK54827.1 - 2.7e-15 56.0 77.0 9.9e-05 22.6 0.7 10.5 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54827.1 - 8.9e-15 54.1 82.0 0.021 15.6 1.0 11.5 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK54827.1 - 1.1e-06 28.9 34.5 0.021 15.1 2.3 5.7 1 1 5 6 6 6 4 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 PIK54827.1 - 0.00049 20.3 36.9 1.7 8.8 0.6 7.4 3 2 4 7 7 7 4 Aberrant zinc-finger zf-TRAF PF02176.18 PIK54827.1 - 0.0006 20.4 38.9 0.0053 17.4 1.0 4.9 3 1 1 4 4 4 3 TRAF-type zinc finger GEN1_C PF18380.1 PIK54827.1 - 1.6 9.7 4.4 0.67 10.9 0.1 2.2 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain zf-C2H2_6 PF13912.6 PIK54827.1 - 2.1 8.5 48.7 0.072 13.1 4.1 8.1 8 0 0 8 8 8 0 C2H2-type zinc finger NPL PF17800.1 PIK54828.1 - 7.3e-11 42.6 0.2 7.3e-11 42.6 0.2 2.4 2 1 0 2 2 1 1 Nucleoplasmin-like domain zf-C2H2_6 PF13912.6 PIK54828.1 - 3.6e-09 36.4 22.5 0.00029 20.7 0.3 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_4 PF13894.6 PIK54828.1 - 1.9e-07 31.3 24.6 0.01 16.6 5.4 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK54828.1 - 4.7e-07 29.9 23.4 0.005 17.2 0.3 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type Elf1 PF05129.13 PIK54828.1 - 0.00038 20.5 19.7 0.036 14.1 0.4 3.4 2 1 1 3 3 3 3 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 PIK54828.1 - 0.00089 19.6 26.8 0.015 15.7 4.1 5.0 5 0 0 5 5 5 2 Zinc-finger double domain C1_4 PF07975.12 PIK54828.1 - 0.011 16.0 12.8 0.75 10.1 0.1 3.6 3 0 0 3 3 3 0 TFIIH C1-like domain zf_Hakai PF18408.1 PIK54828.1 - 0.015 15.0 0.3 0.015 15.0 0.3 2.2 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_jaz PF12171.8 PIK54828.1 - 0.029 14.7 20.5 0.14 12.5 6.2 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 PIK54828.1 - 0.047 13.3 0.2 0.047 13.3 0.2 3.1 3 1 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-RING_11 PF17123.5 PIK54828.1 - 0.051 13.3 0.1 0.051 13.3 0.1 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-C2H2_11 PF16622.5 PIK54828.1 - 0.088 12.6 6.8 0.72 9.7 0.1 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type FOXP-CC PF16159.5 PIK54828.1 - 0.23 12.1 5.3 3.4 8.3 0.4 2.9 2 1 0 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 PIK54828.1 - 0.28 11.0 5.2 0.62 9.9 5.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 PIK54828.1 - 4.4 7.7 10.9 12 6.3 1.1 3.0 2 1 1 3 3 3 0 C2H2-type zinc ribbon TFIIS_C PF01096.18 PIK54828.1 - 5.2 7.0 12.2 1.3 9.0 0.1 3.4 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-C2H2_2 PF12756.7 PIK54828.1 - 5.5 7.4 17.4 1.5 9.2 3.2 3.4 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 PIK54828.1 - 6 7.2 19.1 0.46 10.8 1.4 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK54829.1 - 8e-05 22.9 25.7 0.02 15.3 4.4 3.5 2 1 1 3 3 3 3 Zinc-finger double domain Scramblase PF03803.15 PIK54829.1 - 0.011 15.0 0.2 0.014 14.7 0.2 1.2 1 0 0 1 1 1 0 Scramblase zf-C2H2_4 PF13894.6 PIK54829.1 - 0.023 15.5 28.7 1 10.4 3.7 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger PyrI_C PF02748.15 PIK54829.1 - 0.47 10.4 10.7 8.1 6.4 0.1 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Actin_micro PF17003.5 PIK54829.1 - 5 6.2 6.5 5.8 6.0 6.5 1.2 1 0 0 1 1 1 0 Putative actin-like family Elf1 PF05129.13 PIK54829.1 - 9.4 6.4 15.2 0.55 10.3 4.5 2.8 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like CAP PF00188.26 PIK54830.1 - 4.9e-20 72.6 2.2 1.2e-19 71.4 2.2 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family EOS1 PF12326.8 PIK54831.1 - 0.021 14.8 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF3139 PF11337.8 PIK54831.1 - 0.13 12.9 0.0 0.52 11.0 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) V-set PF07686.17 PIK54832.1 - 7.4e-08 32.5 2.8 0.02 15.1 0.2 3.3 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK54832.1 - 1.6e-07 31.8 4.5 0.0017 18.9 0.0 3.7 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK54832.1 - 5.5e-05 23.3 2.6 0.023 14.9 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK54832.1 - 0.00012 22.4 5.6 0.0041 17.4 0.1 3.4 3 1 1 4 4 4 2 Immunoglobulin domain Ig_5 PF16681.5 PIK54832.1 - 0.037 14.4 0.4 0.37 11.2 0.1 2.6 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.6 PIK54833.1 - 0.035 14.7 2.2 0.36 11.5 0.1 3.2 3 1 0 3 3 3 0 Immunoglobulin domain tRNA_bind_2 PF13725.6 PIK54834.1 - 0.0038 17.0 0.3 0.0056 16.4 0.3 1.1 1 0 0 1 1 1 1 Possible tRNA binding domain COG6 PF06419.11 PIK54834.1 - 0.055 11.7 0.0 0.068 11.4 0.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Ig_3 PF13927.6 PIK54835.1 - 1.2e-07 32.2 0.8 0.0064 17.1 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK54835.1 - 8.7e-07 29.1 2.0 0.16 12.2 0.1 4.1 4 0 0 4 4 4 3 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK54835.1 - 8.4e-05 22.8 3.3 0.18 12.1 0.1 4.1 4 1 1 5 5 5 2 Immunoglobulin domain ig PF00047.25 PIK54835.1 - 0.0035 17.5 0.5 0.082 13.1 0.0 2.9 4 0 0 4 4 4 1 Immunoglobulin domain RIFIN PF02009.16 PIK54835.1 - 0.011 15.7 1.6 0.015 15.2 1.6 1.2 1 0 0 1 1 1 0 Rifin Ig_5 PF16681.5 PIK54835.1 - 0.11 12.9 0.3 0.64 10.5 0.1 2.4 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DED PF01335.21 PIK54836.1 - 0.0069 16.7 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Death effector domain zf-B_box PF00643.24 PIK54836.1 - 0.015 15.4 9.4 0.027 14.6 9.4 1.4 1 0 0 1 1 1 0 B-box zinc finger Ig_3 PF13927.6 PIK54837.1 - 4.1e-09 36.9 0.3 0.00049 20.6 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK54837.1 - 7.1e-07 29.4 0.1 0.01 16.0 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK54837.1 - 5.1e-05 23.4 0.1 0.022 14.9 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK54837.1 - 0.0027 18.0 1.8 0.016 15.5 0.1 2.8 3 1 0 3 3 3 1 Immunoglobulin domain DUF3854 PF12965.7 PIK54837.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) BROMI PF14961.6 PIK54839.1 - 0.028 11.9 4.0 0.04 11.4 4.0 1.1 1 0 0 1 1 1 0 Broad-minded protein Acyl-CoA_dh_N PF02771.16 PIK54839.1 - 0.08 13.6 0.1 0.15 12.7 0.1 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain DUF4239 PF14023.6 PIK54839.1 - 0.59 9.8 2.2 1.2 8.9 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Latarcin PF10279.9 PIK54839.1 - 0.67 10.4 3.0 1.1 9.7 0.2 2.2 2 0 0 2 2 2 0 Latarcin precursor PRKG1_interact PF15898.5 PIK54839.1 - 2.7 9.0 10.9 7.8 7.5 10.9 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 PIK54839.1 - 9.7 6.9 8.9 1.5 9.5 1.1 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Lectin_C PF00059.21 PIK54840.1 - 8.9e-10 39.3 0.0 1.1e-09 39.0 0.0 1.1 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK54840.1 - 0.05 13.2 0.2 0.065 12.9 0.2 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Scramblase PF03803.15 PIK54842.1 - 4.4e-22 78.5 0.3 4.7e-22 78.4 0.3 1.0 1 0 0 1 1 1 1 Scramblase Tox-MPTase3 PF15639.6 PIK54842.1 - 0.061 13.2 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase toxin 3 EutQ PF06249.12 PIK54842.1 - 0.088 12.6 0.0 0.097 12.4 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ Scramblase PF03803.15 PIK54843.1 - 7.1e-66 221.7 0.0 8.6e-66 221.4 0.0 1.0 1 0 0 1 1 1 1 Scramblase Scramblase PF03803.15 PIK54844.1 - 6.4e-76 254.5 0.0 7.7e-76 254.2 0.0 1.0 1 0 0 1 1 1 1 Scramblase NAD_binding_5 PF07994.12 PIK54845.1 - 1.4e-27 97.0 0.0 1.6e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 PIK54845.1 - 9.4e-15 54.8 0.1 1.4e-14 54.2 0.1 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase NAD_binding_5 PF07994.12 PIK54846.1 - 2e-45 155.6 0.0 4.4e-45 154.5 0.0 1.5 1 1 1 2 2 2 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 PIK54846.1 - 1.6e-14 54.1 0.3 2.4e-14 53.5 0.3 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase DUF2927 PF11150.8 PIK54846.1 - 0.082 13.0 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2927) MTS PF05175.14 PIK54847.1 - 0.17 11.4 0.2 0.67 9.5 0.2 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Ig_3 PF13927.6 PIK54848.1 - 0.024 15.2 0.2 13 6.5 0.0 3.2 2 1 1 3 3 3 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK54848.1 - 0.044 13.8 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain 7tm_3 PF00003.22 PIK54849.1 - 9.5e-22 77.9 10.0 2.6e-19 69.9 10.0 2.1 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR bZIP_1 PF00170.21 PIK54849.1 - 0.31 11.2 1.2 0.5 10.5 1.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor DUF4371 PF14291.6 PIK54850.1 - 1.7e-12 47.5 1.1 2.9e-09 36.9 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4371) CD225 PF04505.12 PIK54852.1 - 6.3e-06 26.2 0.4 1.1e-05 25.4 0.4 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Transposase_28 PF04195.12 PIK54852.1 - 0.0021 18.2 0.3 0.0034 17.6 0.3 1.4 1 0 0 1 1 1 1 Putative gypsy type transposon CD225 PF04505.12 PIK54853.1 - 2.7e-06 27.4 0.0 4.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Hormone_recep PF00104.30 PIK54856.1 - 6.8e-18 65.0 0.0 1e-10 41.6 0.0 2.1 2 0 0 2 2 2 2 Ligand-binding domain of nuclear hormone receptor DEAD PF00270.29 PIK54857.1 - 4.6e-30 104.7 0.8 1.4e-29 103.1 0.0 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK54857.1 - 1.8e-24 86.2 0.1 1.7e-23 83.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK54857.1 - 2.3e-18 66.2 0.0 4.3e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 PIK54857.1 - 0.032 14.2 0.0 0.032 14.2 0.0 3.2 4 1 0 4 4 4 0 Type III restriction enzyme, res subunit Mito_carr PF00153.27 PIK54858.1 - 7.5e-39 131.6 0.3 2.2e-14 53.1 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein I-set PF07679.16 PIK54860.1 - 2.2e-08 34.0 0.5 8.1e-06 25.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain TIR_2 PF13676.6 PIK54860.1 - 5.3e-07 30.3 0.2 3.8e-06 27.5 0.0 2.3 3 0 0 3 3 3 1 TIR domain Ig_3 PF13927.6 PIK54860.1 - 3.8e-06 27.4 1.4 0.0064 17.1 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain TIR PF01582.20 PIK54860.1 - 9.4e-06 25.5 0.0 1.6e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.6 PIK54860.1 - 0.0004 20.7 0.6 0.01 16.2 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK54861.1 - 3.6e-14 52.6 0.2 5.4e-08 32.8 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54861.1 - 7.4e-13 48.9 0.1 1.8e-05 25.2 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK54861.1 - 3.5e-10 40.1 0.7 1.1e-05 25.6 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK54861.1 - 1.6e-07 31.4 2.5 0.015 15.5 0.2 2.8 2 2 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK54861.1 - 1.1e-05 25.5 0.2 0.0038 17.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain V-set_CD47 PF08204.11 PIK54861.1 - 4.3e-05 23.5 0.1 0.00012 22.1 0.1 1.8 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Ig_5 PF16681.5 PIK54861.1 - 0.001 19.4 0.8 0.013 15.9 0.1 2.5 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 PIK54861.1 - 0.15 12.1 0.1 0.97 9.5 0.0 2.3 3 0 0 3 3 3 0 C17orf99 Ig domain TIR PF01582.20 PIK54862.1 - 1.2e-14 54.5 0.7 1.9e-14 53.8 0.7 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK54862.1 - 2.3e-14 54.0 0.0 4.6e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain I-set PF07679.16 PIK54862.1 - 2.9e-13 49.7 0.0 9.4e-11 41.6 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK54862.1 - 5.5e-12 46.1 0.9 1.4e-08 35.2 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK54862.1 - 8e-09 35.7 2.3 1.3e-07 31.8 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK54862.1 - 2.4e-06 27.6 0.2 0.00057 20.0 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK54862.1 - 3.2e-05 24.1 5.5 0.0098 16.1 0.1 4.4 3 3 1 4 4 4 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK54862.1 - 0.12 12.4 0.0 0.5 10.5 0.0 2.0 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Death PF00531.22 PIK54863.1 - 0.00021 21.4 0.8 0.00031 20.8 0.1 1.7 2 0 0 2 2 2 1 Death domain ESCRT-II PF05871.12 PIK54863.1 - 0.012 15.8 0.5 0.094 13.0 0.0 2.0 2 0 0 2 2 2 0 ESCRT-II complex subunit SH3_1 PF00018.28 PIK54864.1 - 3.7e-05 23.3 0.0 0.0023 17.5 0.0 2.7 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 PIK54864.1 - 0.0013 18.5 0.0 0.018 14.9 0.0 2.6 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 PIK54864.1 - 0.047 13.4 0.0 0.46 10.2 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain RRM_1 PF00076.22 PIK54866.1 - 6.5e-20 70.7 0.0 1.2e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK54866.1 - 0.0018 18.4 0.0 0.012 15.8 0.0 2.2 2 1 1 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 PIK54866.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF959 PF06121.14 PIK54866.1 - 1.5 9.0 6.3 0.29 11.4 1.5 2.2 2 1 1 3 3 3 0 Domain of Unknown Function (DUF959) RVT_1 PF00078.27 PIK54867.1 - 2e-26 92.9 0.0 2.4e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HeH PF12949.7 PIK54867.1 - 0.13 12.0 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 HeH/LEM domain zf_ZIC PF18366.1 PIK54868.1 - 1.6e-28 98.5 2.1 1.6e-28 98.5 2.1 3.4 4 0 0 4 4 4 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 PIK54868.1 - 3.2e-18 65.1 31.6 5.4e-06 26.6 0.2 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK54868.1 - 1.3e-16 60.2 36.0 2.9e-07 30.6 0.4 5.9 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK54868.1 - 7.1e-09 35.8 28.3 0.0068 17.2 0.2 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK54868.1 - 0.0023 18.2 12.8 2.8 8.4 0.0 4.7 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK54868.1 - 0.0078 16.2 6.8 2.5 8.2 0.0 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK54868.1 - 0.012 15.9 12.2 0.12 12.7 1.9 3.3 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-met PF12874.7 PIK54868.1 - 0.068 13.6 12.9 0.49 10.9 0.2 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type CHORD PF04968.12 PIK54868.1 - 0.11 13.3 18.4 5 7.9 0.3 4.5 2 1 2 4 4 4 0 CHORD FOXP-CC PF16159.5 PIK54868.1 - 0.39 11.4 13.7 18 6.1 0.0 4.9 2 2 3 5 5 5 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 PIK54868.1 - 1.9 8.6 12.1 11 6.1 0.1 3.7 1 1 3 4 4 4 0 Aberrant zinc-finger TNFR_c6 PF00020.18 PIK54870.1 - 1.7e-06 28.3 8.9 0.00035 20.9 5.5 2.3 1 1 1 2 2 2 2 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 PIK54870.1 - 0.01 15.6 2.8 0.01 15.6 2.8 2.6 1 1 0 1 1 1 0 Putative ephrin-receptor like NCD3G PF07562.14 PIK54870.1 - 1.2 9.1 10.3 2.7 8.1 8.4 2.4 2 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Sfi1 PF08457.10 PIK54871.1 - 6.2e-14 51.4 170.7 0.0011 17.6 27.9 9.1 5 3 3 8 8 8 8 Sfi1 spindle body protein Sfi1 PF08457.10 PIK54872.1 - 1e-09 37.5 15.2 1.1e-09 37.5 14.1 1.5 1 1 0 1 1 1 1 Sfi1 spindle body protein Olfactory_mark PF06554.12 PIK54872.1 - 0.064 13.0 1.0 0.17 11.6 1.0 1.8 1 0 0 1 1 1 0 Olfactory marker protein Synaptobrevin PF00957.21 PIK54873.1 - 2.7e-36 123.2 2.7 3.2e-36 123.0 2.7 1.1 1 0 0 1 1 1 1 Synaptobrevin ODV-E18 PF10717.9 PIK54873.1 - 0.0007 19.4 0.4 0.011 15.6 0.1 2.1 2 0 0 2 2 2 1 Occlusion-derived virus envelope protein ODV-E18 Shisa PF13908.6 PIK54873.1 - 0.0073 16.6 1.0 0.011 16.1 1.0 1.5 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2207 PF09972.9 PIK54873.1 - 0.0076 15.1 0.0 0.0077 15.0 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) LMBR1 PF04791.16 PIK54873.1 - 0.015 14.2 0.0 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Env-gp36 PF09590.10 PIK54873.1 - 0.016 13.7 0.0 0.017 13.6 0.0 1.0 1 0 0 1 1 1 0 Lentivirus surface glycoprotein MCU PF04678.13 PIK54873.1 - 0.022 14.9 0.0 0.024 14.7 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF5345 PF17280.2 PIK54873.1 - 0.064 13.2 0.2 0.064 13.2 0.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5345) CD34_antigen PF06365.12 PIK54873.1 - 0.084 12.4 0.1 0.099 12.2 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF3619 PF12279.8 PIK54873.1 - 0.093 13.1 0.1 0.13 12.6 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3619) DUF4736 PF15883.5 PIK54873.1 - 0.12 12.1 6.9 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) Orf78 PF06024.12 PIK54873.1 - 0.17 12.2 1.0 0.26 11.6 1.0 1.4 1 1 0 1 1 1 0 Orf78 (ac78) Ferlin_C PF16165.5 PIK54873.1 - 4.7 7.2 7.4 6.5 6.7 7.0 1.3 1 1 0 1 1 1 0 Ferlin C-terminus UPF0258 PF06789.12 PIK54873.1 - 8.2 6.5 8.0 2 8.5 4.7 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) P53 PF00870.18 PIK54874.1 - 2e-52 177.8 0.0 3.3e-52 177.1 0.0 1.3 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.11 PIK54874.1 - 1.8e-08 33.6 0.2 3.3e-08 32.7 0.2 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.17 PIK54874.1 - 0.00024 21.1 0.0 0.00046 20.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK54874.1 - 0.025 15.0 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Nicastrin PF05450.15 PIK54874.1 - 0.05 13.1 0.2 0.088 12.3 0.2 1.3 1 0 0 1 1 1 0 Nicastrin Voltage_CLC PF00654.20 PIK54875.1 - 6.3e-64 216.4 29.6 3.5e-62 210.7 20.6 2.9 2 1 1 3 3 3 2 Voltage gated chloride channel Adap_comp_sub PF00928.21 PIK54877.1 - 6.8e-80 268.2 0.1 9.1e-80 267.8 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK54877.1 - 3.8e-08 33.4 0.7 6.7e-08 32.6 0.7 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain LRR_9 PF14580.6 PIK54878.1 - 1.3e-06 28.1 0.4 2.1e-06 27.4 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK54878.1 - 0.0014 19.0 4.5 0.03 14.8 0.6 2.7 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK54878.1 - 0.0033 17.2 4.0 0.053 13.3 1.0 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 PIK54878.1 - 0.034 14.7 3.4 3.1 8.7 0.0 4.1 2 1 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK54878.1 - 4.4 7.6 4.7 15 6.0 0.0 3.3 4 0 0 4 4 4 0 Leucine Rich repeat 2OG-FeII_Oxy_3 PF13640.6 PIK54879.1 - 1.4e-13 51.6 0.0 1.7e-08 35.3 0.0 2.5 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 PIK54879.1 - 2.1e-12 47.5 0.1 9.1e-07 29.5 0.0 2.8 3 0 0 3 3 3 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 PIK54879.1 - 0.037 14.4 0.0 0.43 11.0 0.0 2.4 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Ras PF00071.22 PIK54881.1 - 1.2e-10 41.3 0.0 1.5e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK54881.1 - 1.2e-07 31.9 0.0 1.8e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK54881.1 - 0.006 16.5 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase CbiA PF01656.23 PIK54881.1 - 0.072 13.1 0.2 0.54 10.3 0.2 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 PIK54881.1 - 0.082 13.0 0.1 0.17 12.0 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRP54 PF00448.22 PIK54881.1 - 0.099 12.3 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AIG1 PF04548.16 PIK54881.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 AIG1 family zf-H2C2_2 PF13465.6 PIK54882.1 - 1.3e-20 72.8 57.5 1.7e-06 28.2 3.3 9.0 9 0 0 9 9 9 5 Zinc-finger double domain NPL PF17800.1 PIK54882.1 - 1.1e-16 61.2 0.1 3.8e-16 59.5 0.1 1.9 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-C2H2_4 PF13894.6 PIK54882.1 - 4.9e-13 48.7 60.4 0.0038 17.9 1.6 7.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK54882.1 - 7.5e-12 45.0 65.3 4.7e-05 23.6 2.2 7.4 7 0 0 7 7 7 5 Zinc finger, C2H2 type C1_4 PF07975.12 PIK54882.1 - 0.012 15.8 28.2 0.13 12.5 2.6 5.5 3 1 1 5 5 5 0 TFIIH C1-like domain zf-met PF12874.7 PIK54882.1 - 0.096 13.1 0.4 0.096 13.1 0.4 5.6 7 0 0 7 7 7 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK54882.1 - 0.35 10.8 20.6 6.1 6.8 0.2 6.4 7 0 0 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK54882.1 - 0.47 10.8 0.0 0.34 11.3 0.2 6.8 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 PIK54882.1 - 3.9 7.8 17.5 0.35 11.2 1.3 3.7 3 1 1 4 4 4 0 zinc-finger-containing domain LapA_dom PF06305.11 PIK54883.1 - 0.27 11.1 0.7 1.1 9.1 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Man-6-P_recep PF02157.15 PIK54884.1 - 2e-58 197.5 0.9 6.4e-34 117.2 0.1 2.0 2 0 0 2 2 2 2 Mannose-6-phosphate receptor ATG27 PF09451.10 PIK54884.1 - 0.00067 19.6 0.1 0.016 15.1 0.0 2.4 2 1 0 2 2 2 1 Autophagy-related protein 27 CIMR PF00878.18 PIK54884.1 - 0.075 13.1 0.1 0.2 11.7 0.0 1.7 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat EF-hand_7 PF13499.6 PIK54885.1 - 1.6e-22 79.7 3.6 1.1e-11 45.0 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK54885.1 - 3.1e-19 68.6 4.0 3.8e-10 39.5 0.2 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK54885.1 - 6.9e-17 59.7 10.6 7.5e-06 25.1 2.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 PIK54885.1 - 1.6e-16 58.8 4.0 0.001 18.8 0.0 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK54885.1 - 4.8e-08 32.1 6.7 0.016 14.7 0.4 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 PIK54885.1 - 0.0011 18.9 1.3 0.011 15.7 0.1 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SurA_N_2 PF13623.6 PIK54885.1 - 0.0065 16.4 1.0 0.5 10.2 0.1 2.2 2 0 0 2 2 2 1 SurA N-terminal domain EF-hand_9 PF14658.6 PIK54885.1 - 0.011 16.1 0.1 0.81 10.1 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 PIK54885.1 - 0.013 15.3 1.7 0.038 13.8 0.3 2.0 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 PIK54885.1 - 0.015 15.6 0.6 0.5 10.7 0.2 2.5 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 PIK54885.1 - 0.019 15.3 0.6 1.1 9.6 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain TerB PF05099.13 PIK54885.1 - 0.036 14.0 3.3 1.5 8.8 0.2 2.3 1 1 2 3 3 3 0 Tellurite resistance protein TerB LETM1 PF07766.13 PIK54885.1 - 0.06 12.7 0.2 0.081 12.3 0.2 1.5 1 1 0 1 1 1 0 LETM1-like protein DUF3879 PF12995.7 PIK54885.1 - 0.1 12.3 0.9 0.42 10.3 0.8 1.9 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3879) Frankia_peptide PF14407.6 PIK54885.1 - 0.14 12.1 1.1 1.2 9.2 0.2 2.4 2 1 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF1296 PF06972.11 PIK54885.1 - 0.16 12.1 1.2 0.54 10.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) DUF1456 PF07308.13 PIK54885.1 - 0.35 11.2 2.0 2.4 8.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) PBC PF03792.13 PIK54886.1 - 6.6e-26 91.3 0.9 1.1e-25 90.5 0.9 1.4 1 0 0 1 1 1 1 PBC domain Homeodomain PF00046.29 PIK54886.1 - 2.3e-19 69.0 1.3 3.9e-19 68.2 1.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK54886.1 - 2.7e-15 56.0 0.1 6.5e-15 54.8 0.0 1.7 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 PIK54886.1 - 0.011 15.5 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Ras PF00071.22 PIK54887.1 - 1.3e-11 44.4 0.0 2.9e-05 23.7 0.1 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK54887.1 - 3.1e-08 33.9 0.8 5.7e-07 29.8 0.3 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK54887.1 - 7.7e-06 25.5 0.1 0.00021 20.8 0.1 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK54887.1 - 0.00016 21.8 0.0 0.00042 20.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4430 PF14478.6 PIK54888.1 - 1.6e-06 28.6 0.0 3.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) Cobalamin_bind PF01122.19 PIK54888.1 - 0.0047 15.9 0.0 0.0057 15.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein Cobalamin_bind PF01122.19 PIK54889.1 - 9.4e-07 28.0 0.0 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein TED_complement PF07678.14 PIK54889.1 - 0.28 10.2 0.2 0.45 9.5 0.2 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain RRN3 PF05327.11 PIK54889.1 - 4.8 5.6 22.1 6.8 5.1 22.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 PIK54889.1 - 7.6 4.6 23.8 10 4.2 23.8 1.2 1 0 0 1 1 1 0 Nop14-like family zf-C3HC4_3 PF13920.6 PIK54889.1 - 7.7 6.5 9.4 7.9 6.4 0.0 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) APH PF01636.23 PIK54890.1 - 4.7e-08 33.2 0.0 9.6e-07 29.0 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Cobalamin_bind PF01122.19 PIK54891.1 - 2.4e-24 85.8 0.0 3.3e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.6 PIK54891.1 - 0.0049 17.4 0.0 0.0098 16.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) TED_complement PF07678.14 PIK54891.1 - 0.11 11.5 2.5 0.23 10.4 0.3 2.2 2 1 1 3 3 3 0 A-macroglobulin TED domain SQHop_cyclase_C PF13243.6 PIK54891.1 - 0.12 11.4 0.5 5.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain WD40 PF00400.32 PIK54892.1 - 4.1e-17 62.2 6.0 0.035 15.0 0.0 6.9 6 0 0 6 6 6 5 WD domain, G-beta repeat WD40_like PF17005.5 PIK54892.1 - 5.9e-07 29.1 1.6 3.3e-05 23.4 0.1 2.6 2 1 1 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 PIK54892.1 - 0.0006 20.1 1.2 0.75 10.1 0.6 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CDO_I PF05995.12 PIK54892.1 - 0.021 14.1 0.3 0.043 13.1 0.3 1.4 1 0 0 1 1 1 0 Cysteine dioxygenase type I PALB2_WD40 PF16756.5 PIK54892.1 - 0.048 12.6 0.1 2.8 6.8 0.1 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain SAE2 PF08573.10 PIK54892.1 - 0.1 13.7 1.5 0.36 12.0 1.5 1.9 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus ISG65-75 PF11727.8 PIK54892.1 - 0.18 11.0 2.2 1.5 8.0 1.0 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein 7tm_3 PF00003.22 PIK54894.1 - 0.00026 20.8 4.3 0.00036 20.3 4.3 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2968 PF11180.8 PIK54894.1 - 0.025 14.2 1.4 0.035 13.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF883 PF05957.13 PIK54894.1 - 0.039 14.6 0.9 0.062 13.9 0.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) ATP-synt_8 PF00895.20 PIK54894.1 - 0.17 12.4 1.9 0.19 12.2 0.0 2.1 2 0 0 2 2 2 0 ATP synthase protein 8 FemAB PF02388.16 PIK54894.1 - 0.2 10.5 1.7 0.26 10.1 1.7 1.1 1 0 0 1 1 1 0 FemAB family UQ_con PF00179.26 PIK54895.1 - 1.3e-05 24.8 0.0 2.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme MiAMP1 PF09117.10 PIK54895.1 - 1.9 8.8 6.4 13 6.1 1.4 2.7 1 1 1 2 2 2 0 MiAMP1 zf-C3HC PF07967.13 PIK54896.1 - 1e-31 109.7 4.4 6.8e-30 103.8 0.4 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 PIK54896.1 - 2.7e-16 59.5 7.8 1.9e-14 53.6 0.8 3.3 2 2 0 2 2 2 2 Rsm1-like BIR PF00653.21 PIK54896.1 - 0.034 14.8 2.3 1.2 9.9 0.3 2.8 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain DUF4611 PF15387.6 PIK54896.1 - 0.2 11.9 2.4 0.62 10.3 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF4045 PF13254.6 PIK54897.1 - 0.011 15.4 16.9 0.013 15.2 16.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Raftlin PF15250.6 PIK54897.1 - 0.018 13.8 7.4 0.024 13.4 7.4 1.1 1 0 0 1 1 1 0 Raftlin MID_MedPIWI PF18296.1 PIK54897.1 - 0.029 14.2 4.8 0.04 13.7 4.8 1.3 1 0 0 1 1 1 0 MID domain of medPIWI Trypan_PARP PF05887.11 PIK54897.1 - 0.085 12.8 38.0 0.23 11.5 37.7 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SAPS PF04499.15 PIK54897.1 - 0.15 10.8 7.1 0.16 10.8 7.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 PIK54897.1 - 0.17 10.6 14.8 0.22 10.3 14.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Velvet PF11754.8 PIK54897.1 - 0.33 10.9 8.0 0.47 10.4 8.0 1.2 1 0 0 1 1 1 0 Velvet factor DUF1682 PF07946.14 PIK54897.1 - 0.38 9.9 8.9 0.55 9.4 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) U79_P34 PF03064.16 PIK54897.1 - 0.58 9.5 11.1 0.94 8.8 11.1 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF913 PF06025.12 PIK54897.1 - 0.72 8.8 9.0 1.1 8.2 9.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 PIK54897.1 - 2.8 6.0 16.5 3.5 5.6 16.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 PIK54897.1 - 3.3 6.0 3.9 4.9 5.4 3.9 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 PIK54897.1 - 3.5 6.3 9.6 1.1 8.0 7.0 1.4 2 0 0 2 2 2 0 Aluminium activated malate transporter Presenilin PF01080.17 PIK54897.1 - 5.3 5.7 21.1 8 5.1 21.1 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 PIK54897.1 - 7.7 4.6 22.3 12 4.0 22.3 1.3 1 0 0 1 1 1 0 Nop14-like family PNISR PF15996.5 PIK54897.1 - 9.4 6.5 27.5 14 5.8 27.5 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR fn3 PF00041.21 PIK54898.1 - 6.1e-05 23.3 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Ig_3 PF13927.6 PIK54899.1 - 5.5e-15 55.7 0.0 4.5e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK54899.1 - 1.8e-11 44.0 0.0 2e-06 27.8 0.0 2.2 1 1 1 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK54899.1 - 4.5e-10 39.6 0.0 3.8e-06 27.0 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK54899.1 - 2.8e-08 33.9 1.0 0.012 15.7 0.2 3.3 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK54899.1 - 2.1e-07 31.2 0.0 0.00044 20.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 PIK54899.1 - 0.0011 18.5 0.1 0.017 14.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Herpes_gE PF02480.16 PIK54899.1 - 0.0011 17.8 0.0 0.25 10.0 0.0 2.1 2 0 0 2 2 2 2 Alphaherpesvirus glycoprotein E V-set_CD47 PF08204.11 PIK54899.1 - 0.12 12.4 0.2 2 8.4 0.0 2.2 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain DUF498 PF04430.14 PIK54900.1 - 1.7e-23 82.7 0.0 1.9e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) DUF2647 PF10839.8 PIK54900.1 - 0.089 12.9 0.0 1.6 8.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2647) STIMATE PF12400.8 PIK54901.1 - 3.3e-19 69.7 7.6 3.3e-19 69.7 7.6 2.1 3 0 0 3 3 3 1 STIMATE family TMEM220 PF15071.6 PIK54901.1 - 0.002 18.8 2.5 0.03 15.1 0.3 2.5 2 0 0 2 2 2 1 Transmembrane family 220, helix LRRNT_2 PF08263.12 PIK54901.1 - 0.046 14.0 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain MBT PF02820.18 PIK54902.1 - 5.8e-82 270.0 0.2 6.6e-21 74.4 0.0 4.4 4 0 0 4 4 4 4 mbt repeat SLED PF12140.8 PIK54902.1 - 1e-31 109.7 2.9 1.3e-31 109.4 0.1 2.5 2 0 0 2 2 2 1 SLED domain SAM_1 PF00536.30 PIK54902.1 - 1.8e-09 37.9 0.0 3.3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK54902.1 - 3.1e-05 24.0 0.0 0.00012 22.1 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK54902.1 - 0.00022 21.1 0.0 0.00055 19.8 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 PIK54902.1 - 0.074 13.3 0.2 0.16 12.2 0.2 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif 7tm_1 PF00001.21 PIK54904.1 - 1.7e-31 109.5 13.7 1.7e-31 109.5 13.7 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK54904.1 - 3.4e-05 23.4 12.9 5.3e-05 22.7 12.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK54904.1 - 0.0017 18.0 19.6 0.0025 17.5 18.1 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK54906.1 - 1e-23 84.1 1.0 1e-23 84.1 1.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK54906.1 - 5.9e-06 26.1 8.8 1.5e-05 24.7 8.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK54906.1 - 5.3e-05 22.7 3.6 7.2e-05 22.3 3.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK54907.1 - 1e-41 143.1 8.2 1e-41 143.1 8.2 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK54907.1 - 3.1e-05 23.5 9.8 3.1e-05 23.5 9.8 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK54907.1 - 4.9e-05 23.1 15.3 4.9e-05 23.1 15.3 2.6 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF5056 PF16479.5 PIK54907.1 - 0.38 11.0 5.7 0.17 12.2 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) MAM33 PF02330.16 PIK54908.1 - 0.027 14.4 9.3 1.4 8.8 4.7 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein Tetraspanin PF00335.20 PIK54908.1 - 0.037 13.7 0.5 0.057 13.1 0.5 1.3 1 0 0 1 1 1 0 Tetraspanin family SAPS PF04499.15 PIK54908.1 - 1.3 7.8 7.1 1.7 7.3 7.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2428 PF10350.9 PIK54908.1 - 4.9 6.3 6.8 0.85 8.8 0.1 2.0 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) Orf78 PF06024.12 PIK54908.1 - 6.1 7.2 9.2 0.91 9.9 1.7 2.5 2 1 0 2 2 2 0 Orf78 (ac78) 7tm_1 PF00001.21 PIK54909.1 - 2.9e-45 154.6 7.6 3.6e-45 154.3 7.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK54909.1 - 1.8e-05 24.3 9.4 1.8e-05 24.3 9.4 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK54909.1 - 2.3e-05 24.2 14.9 2.3e-05 24.2 14.9 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx COG5 PF10392.9 PIK54910.1 - 1.9e-12 47.5 1.3 1.9e-12 47.5 1.3 3.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 NPV_P10 PF05531.12 PIK54910.1 - 0.015 15.8 1.6 1.3 9.6 0.0 3.8 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein MID_MedPIWI PF18296.1 PIK54910.1 - 0.052 13.3 0.6 10 5.8 0.0 3.0 3 0 0 3 3 3 0 MID domain of medPIWI DUF3135 PF11333.8 PIK54910.1 - 1.1 9.6 4.2 1.5 9.1 0.2 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3135) Baculo_PEP_C PF04513.12 PIK54910.1 - 7.2 6.6 8.2 5 7.2 0.3 3.3 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps62 PF06101.11 PIK54911.1 - 5.3e-23 81.1 0.0 1e-10 40.6 0.0 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 62 CPCFC PF17223.3 PIK54912.1 - 0.19 11.5 2.3 71 3.3 0.1 3.3 3 0 0 3 3 3 0 Cuticle protein CPCFC TRH PF05438.12 PIK54914.1 - 8.2e-13 48.6 26.7 8e-07 29.0 2.5 3.7 1 1 2 3 3 3 3 Thyrotropin-releasing hormone (TRH) Methyltransf_1N PF02870.15 PIK54914.1 - 0.00034 21.3 2.9 2.3e+02 2.7 0.1 7.6 7 2 1 8 8 8 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Phage_tail_3 PF08813.11 PIK54914.1 - 0.1 12.2 0.0 21 4.7 0.0 3.5 3 1 1 4 4 4 0 Phage tail tube protein, TTP DUF4057 PF13266.6 PIK54914.1 - 0.61 9.7 15.4 53 3.4 0.1 6.9 5 2 3 8 8 8 0 Protein of unknown function (DUF4057) SNF PF00209.18 PIK54915.1 - 3.3e-196 653.0 34.6 3.9e-196 652.8 34.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 PIK54916.1 - 8.3e-208 691.3 38.9 9.5e-208 691.1 38.9 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family MAGE PF01454.19 PIK54917.1 - 3.4e-08 33.5 0.0 4.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 MAGE family zf-C3HC4 PF00097.25 PIK54918.1 - 2.6e-09 36.8 10.3 2.6e-09 36.8 10.3 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK54918.1 - 7.2e-09 35.5 7.6 7.2e-09 35.5 7.6 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK54918.1 - 2.2e-07 30.6 10.6 2.2e-07 30.6 10.6 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK54918.1 - 2.1e-06 27.8 9.7 2.1e-06 27.8 9.7 3.8 3 2 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK54918.1 - 2.2e-06 27.4 10.8 2.2e-06 27.4 10.8 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK54918.1 - 1.5e-05 25.0 28.7 0.00012 22.1 12.0 4.2 5 0 0 5 5 5 2 B-box zinc finger zf-RING_5 PF14634.6 PIK54918.1 - 2.2e-05 24.3 8.8 2.2e-05 24.3 8.8 3.6 3 0 0 3 3 3 2 zinc-RING finger domain zf-RING_2 PF13639.6 PIK54918.1 - 2.4e-05 24.5 8.9 2.4e-05 24.5 8.9 3.8 3 0 0 3 3 2 1 Ring finger domain Prok-RING_4 PF14447.6 PIK54918.1 - 0.0034 17.2 11.2 0.0034 17.2 11.2 3.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 SPATIAL PF15256.6 PIK54918.1 - 0.48 10.7 7.1 0.26 11.6 4.2 1.9 1 1 1 2 2 2 0 SPATIAL Phage_lysis PF03245.13 PIK54918.1 - 1.3 9.2 5.4 3.3 7.8 5.4 1.6 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein Exonuc_VII_L PF02601.15 PIK54918.1 - 4.8 6.6 10.8 8.7 5.8 10.8 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 PIK54918.1 - 9.7 5.4 10.6 15 4.8 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_UBOX PF13445.6 PIK54919.1 - 6.9e-09 35.6 2.9 6.9e-09 35.6 2.9 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54919.1 - 5e-08 32.7 3.8 5e-08 32.7 3.8 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK54919.1 - 2.4e-05 24.1 5.2 2.4e-05 24.1 5.2 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK54919.1 - 0.00019 21.5 4.7 0.00019 21.5 4.7 3.6 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK54919.1 - 0.00032 20.5 6.5 0.00032 20.5 6.5 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 PIK54919.1 - 0.0084 16.2 10.5 0.0084 16.2 10.5 4.0 5 0 0 5 5 5 2 B-box zinc finger WD40_like PF17005.5 PIK54919.1 - 0.039 13.3 1.8 2.4 7.4 0.0 2.9 1 1 1 2 2 2 0 WD40-like domain NHL PF01436.21 PIK54919.1 - 0.19 11.9 0.4 9.4 6.5 0.2 2.9 2 0 0 2 2 2 0 NHL repeat Fzo_mitofusin PF04799.13 PIK54919.1 - 5 6.7 11.1 7.1 6.1 3.9 3.3 2 1 1 3 3 3 0 fzo-like conserved region zf-RING_UBOX PF13445.6 PIK54920.1 - 1.5e-10 40.9 5.9 1.5e-10 40.9 5.9 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK54920.1 - 3.9e-10 39.4 7.5 3.9e-10 39.4 7.5 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK54920.1 - 5.8e-07 29.2 8.6 5.8e-07 29.2 8.6 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK54920.1 - 1.6e-06 27.9 9.7 1.6e-06 27.9 9.7 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK54920.1 - 3.5e-06 27.2 7.4 3.5e-06 27.2 7.4 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK54920.1 - 1.2e-05 25.4 8.6 1.2e-05 25.4 8.6 3.9 3 1 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK54920.1 - 1.9e-05 24.5 6.9 1.9e-05 24.5 6.9 3.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-B_box PF00643.24 PIK54920.1 - 3.2e-05 24.0 28.5 0.00025 21.1 12.7 4.3 6 0 0 6 6 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK54920.1 - 0.0049 16.7 10.7 0.0049 16.7 10.7 4.1 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 HSBP1 PF06825.12 PIK54920.1 - 0.015 15.1 0.7 0.041 13.8 0.3 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF4407 PF14362.6 PIK54920.1 - 8.7 5.6 10.7 14 5.0 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.27 PIK54921.1 - 0.00037 20.1 0.0 0.00054 19.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aldedh PF00171.22 PIK54922.1 - 8.7e-31 106.9 0.3 1.1e-30 106.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4682 PF15733.5 PIK54922.1 - 0.063 13.9 0.0 0.095 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4682) ACT_4 PF13291.6 PIK54922.1 - 0.083 13.5 0.0 7.5 7.2 0.0 2.8 4 0 0 4 4 4 0 ACT domain GAT PF03127.14 PIK54923.1 - 1.1e-23 83.3 2.0 2.9e-23 82.0 2.0 1.8 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 PIK54923.1 - 1.4e-18 67.1 0.1 2.9e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 VHS domain Baculo_PEP_C PF04513.12 PIK54923.1 - 0.02 14.9 0.5 0.057 13.5 0.5 1.7 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ParB PF08775.10 PIK54923.1 - 0.12 12.9 0.3 0.6 10.6 0.0 2.1 2 0 0 2 2 2 0 ParB family LRR_9 PF14580.6 PIK54924.1 - 2.3e-15 56.5 3.9 2.3e-15 56.5 3.9 3.4 2 1 2 4 4 4 2 Leucine-rich repeat LRR_4 PF12799.7 PIK54924.1 - 4.8e-14 52.2 26.2 7.8e-06 26.2 2.4 4.1 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK54924.1 - 1.6e-06 27.8 22.2 0.00016 21.3 7.2 3.5 1 1 2 3 3 3 3 Leucine rich repeat HTH_OrfB_IS605 PF12323.8 PIK54924.1 - 0.04 13.4 0.0 0.084 12.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain LRR_1 PF00560.33 PIK54924.1 - 0.16 12.6 12.7 2.1 9.2 0.0 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat ATP12 PF07542.11 PIK54925.1 - 1.8e-38 131.5 0.2 4.1e-38 130.4 0.1 1.6 2 0 0 2 2 2 1 ATP12 chaperone protein Vac_ImportDeg PF09783.9 PIK54926.1 - 3.2e-58 196.1 3.9 3.7e-58 195.9 3.9 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein Med7 PF05983.11 PIK54927.1 - 1e-44 152.9 5.8 1e-44 152.9 5.8 2.3 2 1 0 2 2 2 1 MED7 protein ABC2_membrane_3 PF12698.7 PIK54928.1 - 4.4e-54 183.9 49.8 1.6e-35 122.9 16.8 2.9 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 PIK54928.1 - 1.9e-35 122.3 0.8 4.9e-18 66.0 0.0 3.4 2 1 1 3 3 3 3 ABC transporter AAA_21 PF13304.6 PIK54928.1 - 7.8e-19 68.6 0.2 1.6e-06 28.2 0.0 3.8 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 PIK54928.1 - 3.8e-05 24.3 0.6 0.0008 20.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 PIK54928.1 - 0.0057 16.4 0.0 0.67 9.6 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 PIK54928.1 - 0.032 13.7 0.1 2.6 7.4 0.1 2.9 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 PIK54928.1 - 0.034 14.4 0.0 8.7 6.7 0.1 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 PIK54928.1 - 0.1 12.9 0.2 0.71 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 PIK54928.1 - 0.14 12.1 1.1 0.49 10.3 0.1 2.3 3 0 0 3 3 3 0 RsgA GTPase AAA_29 PF13555.6 PIK54928.1 - 0.2 11.4 1.2 0.32 10.8 0.1 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 PIK54928.1 - 0.26 11.0 0.9 1 9.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 PIK54928.1 - 1.2 8.7 4.8 0.62 9.6 0.7 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DAGK_cat PF00781.24 PIK54929.1 - 1.3e-26 92.6 0.0 3.2e-26 91.4 0.0 1.6 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain DUF1730 PF08331.10 PIK54930.1 - 0.73 9.8 3.8 2.6 8.0 0.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1730) SOG2 PF10428.9 PIK54931.1 - 2.4 7.3 6.0 5.9 6.0 6.0 1.6 1 0 0 1 1 1 0 RAM signalling pathway protein ALS2CR8 PF15299.6 PIK54932.1 - 2.8e-38 132.0 6.5 5.6e-38 131.0 6.5 1.5 1 1 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 SWIM PF04434.17 PIK54932.1 - 0.026 14.2 0.6 0.056 13.1 0.6 1.5 1 0 0 1 1 1 0 SWIM zinc finger PX PF00787.24 PIK54933.1 - 3.4e-17 62.4 2.3 5.7e-17 61.7 2.3 1.4 1 0 0 1 1 1 1 PX domain EF-hand_4 PF12763.7 PIK54933.1 - 0.0036 17.2 0.1 0.05 13.6 0.0 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand BAR_3_WASP_bdg PF10456.9 PIK54934.1 - 0.011 15.2 0.4 0.014 14.9 0.4 1.3 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein DDE_Tnp_IS1595 PF12762.7 PIK54934.1 - 0.038 14.0 0.1 0.099 12.7 0.1 1.8 1 1 0 1 1 1 0 ISXO2-like transposase domain Ank_2 PF12796.7 PIK54935.1 - 9.5e-26 90.2 0.5 1.3e-12 48.1 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54935.1 - 7.2e-19 67.9 0.3 7.7e-07 29.5 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK54935.1 - 9.8e-14 51.2 0.1 4e-10 39.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK54935.1 - 3.7e-12 46.1 2.3 5.4e-05 23.4 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 PIK54935.1 - 1.4e-08 34.3 0.1 0.00089 19.5 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Fam20C PF06702.12 PIK54936.1 - 2.6e-100 334.7 0.2 3.6e-100 334.3 0.2 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK54936.1 - 0.018 14.0 0.0 0.036 12.9 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein RT_RNaseH_2 PF17919.1 PIK54937.1 - 1.5e-36 124.4 0.1 5e-36 122.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK54937.1 - 2e-33 114.8 0.0 5.5e-33 113.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK54937.1 - 2.9e-18 65.7 2.4 6e-18 64.7 2.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK54937.1 - 7.6e-17 61.6 0.1 1.9e-13 50.4 0.1 2.6 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK54937.1 - 6.4e-16 58.6 0.0 1.6e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK54937.1 - 4e-08 33.3 0.1 1.1e-07 31.9 0.1 1.8 1 0 0 1 1 1 1 H2C2 zinc finger PHD PF00628.29 PIK54937.1 - 4e-08 33.0 7.9 1.8e-07 31.0 7.9 2.1 1 0 0 1 1 1 1 PHD-finger SCAN PF02023.17 PIK54937.1 - 0.0068 16.2 0.9 0.085 12.7 0.0 3.0 3 0 0 3 3 3 1 SCAN domain zf-CW PF07496.15 PIK54937.1 - 0.13 12.3 5.9 0.45 10.6 4.8 2.4 2 0 0 2 2 2 0 CW-type Zinc Finger TFCD_C PF12612.8 PIK54938.1 - 1.3e-61 207.8 0.3 1.5e-60 204.3 0.1 2.9 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 PIK54938.1 - 0.00029 21.1 2.2 0.042 14.2 0.1 4.4 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 PIK54938.1 - 0.00059 19.9 5.7 0.51 10.7 0.0 6.4 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 PIK54938.1 - 0.00071 20.0 0.7 5 7.7 0.0 4.6 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 PIK54938.1 - 0.029 14.4 0.1 0.63 10.1 0.0 3.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Fam20C PF06702.12 PIK54939.1 - 3.3e-83 278.8 0.1 4.6e-83 278.3 0.1 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK54939.1 - 0.0091 14.9 0.0 0.021 13.7 0.0 1.6 2 0 0 2 2 2 1 FAM198 protein Fam20C PF06702.12 PIK54940.1 - 8.9e-86 287.2 0.3 1.4e-85 286.6 0.3 1.3 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK54940.1 - 0.026 13.4 0.0 0.047 12.6 0.0 1.3 1 0 0 1 1 1 0 FAM198 protein RRP7 PF12923.7 PIK54941.1 - 1.5e-12 47.7 4.5 1.5e-12 47.7 4.5 1.9 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 PIK54941.1 - 2.3e-07 30.8 0.9 6.7e-07 29.2 0.1 2.2 1 1 1 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 PIK54941.1 - 5.2e-06 26.2 0.1 9.4e-05 22.2 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5093 PF17011.5 PIK54941.1 - 0.004 17.4 0.9 0.004 17.4 0.9 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF5093) PHM7_cyt PF14703.6 PIK54941.1 - 0.0086 16.3 1.0 1 9.5 1.0 2.5 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Sld7_C PF18596.1 PIK54941.1 - 0.083 13.0 0.6 0.23 11.6 0.2 2.1 2 1 0 2 2 2 0 Sld7 C-terminal domain RRM_7 PF16367.5 PIK54941.1 - 0.087 13.0 0.1 0.25 11.5 0.1 1.9 1 1 0 1 1 1 0 RNA recognition motif CAF20 PF17052.5 PIK54941.1 - 0.14 12.3 4.1 0.082 13.1 1.9 1.8 2 0 0 2 2 2 0 Cap associated factor DUF4507 PF14964.6 PIK54942.1 - 1.8e-49 168.6 4.7 2.6e-49 168.1 4.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) dCMP_cyt_deam_1 PF00383.23 PIK54943.1 - 2.2e-21 75.6 0.1 3.1e-21 75.1 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 PIK54943.1 - 5.9e-19 68.2 0.1 8.2e-19 67.7 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 PIK54943.1 - 0.0018 18.4 1.3 0.02 15.0 1.3 2.1 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 PIK54943.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 PIK54943.1 - 0.0084 16.2 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 PIK54943.1 - 0.016 15.3 0.0 0.021 15.0 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 PIK54943.1 - 0.024 14.8 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 APOBEC3 NAD2 PF18782.1 PIK54943.1 - 0.035 14.2 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Aminoglyc_resit PF10706.9 PIK54943.1 - 0.043 13.5 0.1 0.28 10.9 0.1 1.9 1 1 1 2 2 2 0 Aminoglycoside-2''-adenylyltransferase APOBEC1 PF18769.1 PIK54943.1 - 0.08 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 APOBEC1 E2F_TDP PF02319.20 PIK54944.1 - 2.5e-24 85.1 0.1 4.7e-24 84.2 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 PIK54944.1 - 7.3e-24 84.0 0.0 1.7e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain CIMR PF00878.18 PIK54946.1 - 2.9e-139 458.6 27.3 7.6e-34 116.8 0.7 6.3 6 0 0 6 6 6 6 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 PIK54946.1 - 3.8e-33 115.5 20.1 1.9e-08 34.5 0.4 6.2 2 2 4 6 6 6 5 Autophagy-related protein 27 Man-6-P_recep PF02157.15 PIK54946.1 - 1.9e-20 73.0 2.9 3.6e-07 29.5 0.1 5.0 3 1 2 5 5 5 4 Mannose-6-phosphate receptor CIMR PF00878.18 PIK54947.1 - 2.5e-34 118.4 9.5 2.1e-17 63.6 0.8 4.0 3 1 1 4 4 4 3 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 PIK54947.1 - 6.4e-08 32.0 0.1 0.001 18.3 0.1 2.8 1 1 2 3 3 3 2 Mannose-6-phosphate receptor ATG27 PF09451.10 PIK54947.1 - 7.2e-07 29.3 3.8 0.00075 19.4 0.5 3.7 1 1 2 3 3 3 2 Autophagy-related protein 27 PRKCSH_1 PF13015.6 PIK54947.1 - 1.3e-05 25.0 1.5 0.12 12.1 0.2 3.3 1 1 2 3 3 3 3 Glucosidase II beta subunit-like protein Omega-toxin PF06357.11 PIK54947.1 - 0.64 9.8 4.1 4 7.3 0.5 3.0 2 0 0 2 2 2 0 Omega-atracotoxin CIMR PF00878.18 PIK54948.1 - 7e-24 84.5 0.3 9.3e-14 51.7 0.8 3.1 3 0 0 3 3 3 3 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 PIK54948.1 - 7.5e-08 32.6 0.0 3.2e-06 27.2 0.0 2.2 1 1 1 2 2 2 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 PIK54948.1 - 0.0015 18.2 0.2 0.015 15.0 0.1 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Man-6-P_recep PF02157.15 PIK54948.1 - 0.0075 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 PIK54949.1 - 1.2e-22 80.6 2.9 4.7e-12 46.2 0.1 3.2 3 0 0 3 3 3 3 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 PIK54949.1 - 2.8e-10 40.5 1.1 3.4e-09 36.9 1.1 2.2 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 PIK54949.1 - 1.9e-05 23.9 1.1 0.0019 17.4 0.0 2.1 2 0 0 2 2 2 2 Mannose-6-phosphate receptor PI3_PI4_kinase PF00454.27 PIK54950.1 - 3.8e-50 171.0 0.0 7.2e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAtT PF16811.5 PIK54950.1 - 0.024 13.9 0.1 0.041 13.2 0.1 1.4 1 0 0 1 1 1 0 TRAP transporter T-component FAT PF02259.23 PIK54951.1 - 2.9e-11 43.2 4.9 2.8e-09 36.7 0.1 2.2 1 1 1 2 2 2 2 FAT domain Syntaxin-6_N PF09177.11 PIK54951.1 - 0.28 11.8 1.7 0.92 10.1 0.8 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HMG_CoA_synt_C PF08540.10 PIK54953.1 - 1.5e-102 343.0 0.0 1.9e-102 342.7 0.0 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 PIK54953.1 - 2.7e-101 336.7 1.0 4.1e-101 336.1 1.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.10 PIK54953.1 - 0.0029 17.4 0.4 0.0073 16.1 0.4 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ank_4 PF13637.6 PIK54954.1 - 3.8e-19 68.8 4.0 2e-05 25.0 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK54954.1 - 1.8e-18 66.9 0.7 4.2e-12 46.5 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK54954.1 - 3.6e-14 52.5 6.5 0.00067 20.0 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK54954.1 - 7.6e-13 48.4 3.2 0.00014 22.1 0.3 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54954.1 - 2e-12 46.1 2.0 0.068 13.8 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 PIK54955.1 - 8.7e-11 42.1 1.1 0.00025 21.6 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK54955.1 - 1.7e-09 38.1 0.1 2.4e-05 24.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK54955.1 - 2.2e-09 36.7 0.3 0.019 15.4 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK54955.1 - 1.1e-08 35.1 0.2 3.5e-05 24.0 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK54955.1 - 4.6e-07 30.0 1.4 0.11 13.0 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Fibrinogen_C PF00147.18 PIK54957.1 - 9.3e-08 32.1 0.0 1.1e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF1115 PF06544.12 PIK54958.1 - 1.2e-45 155.2 3.8 1.2e-45 155.2 3.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Adeno_PV PF03910.13 PIK54958.1 - 0.05 12.3 1.3 0.07 11.8 1.3 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV Beta_propel PF09826.9 PIK54958.1 - 0.1 11.4 0.5 0.13 11.1 0.5 1.0 1 0 0 1 1 1 0 Beta propeller domain DUF3245 PF11595.8 PIK54958.1 - 1.3 9.5 8.3 1 9.8 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) PRP3 PF08572.10 PIK54959.1 - 3.5e-57 193.7 4.6 3.5e-57 193.7 4.6 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) PWI PF01480.17 PIK54959.1 - 9e-08 32.3 0.0 2.2e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 PWI domain Iso_dh PF00180.20 PIK54960.1 - 9.3e-68 228.9 0.0 1.2e-67 228.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 PIK54960.1 - 0.04 14.6 0.1 0.39 11.5 0.0 2.3 3 0 0 3 3 3 0 Phenylalanine zipper AlaDh_PNT_N PF05222.15 PIK54961.1 - 5.3e-46 156.3 0.0 7.9e-46 155.7 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 PIK54961.1 - 1.1e-25 90.3 1.0 1.6e-25 89.6 1.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 PIK54961.1 - 0.017 14.5 0.4 0.18 11.2 0.1 2.7 3 1 1 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 PIK54961.1 - 0.047 12.9 0.4 0.073 12.3 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 PIK54961.1 - 0.068 13.2 0.5 0.7 9.9 0.1 2.5 2 1 1 3 3 3 0 Zinc-binding dehydrogenase PNTB PF02233.16 PIK54962.1 - 3.6e-41 141.5 8.4 3.6e-41 141.5 8.4 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit PNTB_4TM PF12769.7 PIK54962.1 - 1.1e-34 118.8 3.4 1.1e-34 118.8 3.4 3.3 2 1 0 2 2 2 1 4TM region of pyridine nucleotide transhydrogenase, mitoch PNTB PF02233.16 PIK54963.1 - 4.1e-123 411.7 8.8 5.3e-123 411.3 8.8 1.1 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 PIK54963.1 - 0.007 16.1 0.1 0.023 14.4 0.1 1.9 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Phage_holin_2_4 PF16082.5 PIK54963.1 - 0.089 12.5 1.2 0.15 11.8 0.3 1.9 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like Guanylate_cyc PF00211.20 PIK54964.1 - 1.6e-69 233.2 0.1 3.8e-69 232.0 0.1 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK54964.1 - 1.5e-05 24.5 1.0 3.1e-05 23.5 0.7 1.6 2 0 0 2 2 2 1 Heme NO binding associated Pkinase PF00069.25 PIK54965.1 - 3e-14 53.0 0.0 3.6e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK54965.1 - 1.7e-11 43.9 0.0 1.9e-11 43.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase ANF_receptor PF01094.28 PIK54967.1 - 1.1e-22 80.7 0.5 1.1e-22 80.6 0.5 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region ANF_receptor PF01094.28 PIK54968.1 - 5.4e-17 61.9 0.1 6.1e-17 61.8 0.1 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region SH2 PF00017.24 PIK54969.1 - 1.1e-09 38.3 0.1 1.9e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 SH2 domain Lipase PF00151.19 PIK54970.1 - 2.7e-70 237.4 1.8 4e-69 233.5 1.8 2.4 1 1 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 PIK54970.1 - 0.008 16.8 0.2 0.0095 16.6 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family 7tm_1 PF00001.21 PIK54971.1 - 9.4e-22 77.6 8.6 1.1e-21 77.4 8.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TrkH PF02386.16 PIK54971.1 - 0.002 16.7 0.0 0.0031 16.0 0.0 1.3 1 0 0 1 1 1 1 Cation transport protein 7TM_GPCR_Srsx PF10320.9 PIK54971.1 - 0.038 13.4 4.2 0.046 13.1 4.2 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx MscS_TM PF12794.7 PIK54971.1 - 0.1 11.4 3.9 0.21 10.4 0.0 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Serpentine_r_xa PF03383.15 PIK54971.1 - 0.28 11.1 6.0 0.29 11.1 1.6 2.4 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa OppC_N PF12911.7 PIK54971.1 - 2.4 8.2 7.7 1.3 9.0 0.2 2.9 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF3810 PF12725.7 PIK54971.1 - 7.2 5.9 9.7 18 4.5 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) RVT_1 PF00078.27 PIK54972.1 - 2.5e-18 66.4 0.2 6.5e-18 65.1 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 PIK54974.1 - 1.4e-54 182.6 0.0 1.4e-16 60.8 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK54974.1 - 1.7e-38 130.5 0.6 2.1e-08 34.5 0.0 5.7 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK54974.1 - 7.1e-30 102.1 0.0 1.1e-07 31.9 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK54974.1 - 1.2e-29 101.9 0.1 2.3e-09 37.3 0.0 4.4 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK54974.1 - 3.9e-27 91.3 0.0 2.2e-05 24.5 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat TFIIB PF00382.19 PIK54975.1 - 7.4e-05 22.7 0.2 0.016 15.2 0.3 3.0 2 1 0 2 2 2 1 Transcription factor TFIIB repeat A2L_zn_ribbon PF08792.10 PIK54975.1 - 0.026 14.2 5.0 0.051 13.3 3.5 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.12 PIK54975.1 - 0.028 13.9 4.6 0.059 12.9 4.6 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding NinF PF05810.12 PIK54975.1 - 0.08 12.8 5.3 0.21 11.5 1.5 2.5 2 0 0 2 2 2 0 NinF protein Prok-RING_1 PF14446.6 PIK54975.1 - 8.4 6.4 9.9 0.26 11.3 3.2 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 adh_short PF00106.25 PIK54976.1 - 4.8e-19 68.6 0.0 6.5e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK54976.1 - 9.4e-18 64.6 0.0 1.1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK54976.1 - 2.7e-08 33.9 0.0 3.1e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 PIK54976.1 - 4.7e-05 23.3 0.0 6.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 PIK54976.1 - 0.038 13.1 0.1 0.07 12.3 0.1 1.4 1 1 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.19 PIK54976.1 - 0.096 11.7 0.1 0.12 11.3 0.1 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 PIK54976.1 - 0.14 12.4 0.2 0.32 11.3 0.1 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Peptidase_S8 PF00082.22 PIK54977.1 - 2.7e-26 92.5 1.0 8.9e-24 84.3 0.3 2.2 1 1 1 2 2 2 2 Subtilase family Inhibitor_I9 PF05922.16 PIK54977.1 - 8.4e-09 36.0 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Homeodomain PF00046.29 PIK54978.1 - 8.1e-22 76.8 4.7 1.3e-21 76.2 4.7 1.3 1 0 0 1 1 1 1 Homeodomain NAGidase PF07555.13 PIK54979.1 - 1.3e-83 280.7 0.0 1.7e-83 280.3 0.0 1.1 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Acetyltransf_7 PF13508.7 PIK54980.1 - 0.13 12.7 0.0 4.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FAM184 PF15665.5 PIK54983.1 - 3.9e-55 186.9 40.7 5.2e-55 186.5 40.7 1.1 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B MAD PF05557.13 PIK54983.1 - 0.066 11.6 43.4 0.087 11.2 14.7 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Filament PF00038.21 PIK54983.1 - 0.18 11.4 40.1 0.11 12.1 28.1 2.1 1 1 1 2 2 2 0 Intermediate filament protein FAM184 PF15665.5 PIK54984.1 - 4.2e-33 114.9 73.6 1.4e-30 106.7 29.0 6.8 2 1 3 6 6 6 2 Family with sequence similarity 184, A and B GIT_CC PF16559.5 PIK54984.1 - 0.0065 16.3 0.3 0.0065 16.3 0.3 9.1 8 2 2 10 10 10 3 GIT coiled-coil Rho guanine nucleotide exchange factor LPP PF04728.13 PIK54984.1 - 0.025 14.9 0.4 0.025 14.9 0.4 10.3 10 2 0 10 10 10 0 Lipoprotein leucine-zipper Nop14 PF04147.12 PIK54985.1 - 3e-246 819.8 46.5 3.5e-246 819.6 46.5 1.0 1 0 0 1 1 1 1 Nop14-like family Noggin PF05806.12 PIK54985.1 - 2.5 7.9 8.3 0.24 11.3 2.9 2.0 2 0 0 2 2 2 0 Noggin AnkUBD PF18418.1 PIK54986.1 - 3.1e-26 91.3 0.0 5.5e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin ubiquitin-binding domain OTU PF02338.19 PIK54986.1 - 1.5e-17 64.3 0.0 1.6e-11 44.8 0.0 2.7 3 0 0 3 3 3 2 OTU-like cysteine protease MGAT2 PF05060.14 PIK54987.1 - 9.4e-98 327.5 5.6 1e-97 327.3 5.6 1.0 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) TruB_N PF01509.18 PIK54988.1 - 5.8e-40 137.1 0.0 1.3e-39 136.0 0.0 1.5 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 PIK54988.1 - 1e-08 35.2 0.1 3.8e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain CstA PF02554.14 PIK54988.1 - 0.19 10.6 3.0 0.37 9.6 2.4 1.9 2 0 0 2 2 2 0 Carbon starvation protein CstA Ig_3 PF13927.6 PIK54989.1 - 8.6e-15 55.1 0.5 8.7e-11 42.3 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK54989.1 - 2.2e-14 53.4 0.2 7.8e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK54989.1 - 5e-11 42.5 0.0 2.8e-08 33.7 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK54989.1 - 5.5e-10 39.4 0.1 6.9e-09 35.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK54989.1 - 1.8e-09 37.8 0.1 0.00045 20.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK54989.1 - 0.026 14.9 0.0 0.42 11.0 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK54989.1 - 0.078 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK54990.1 - 9e-08 32.6 2.7 0.021 15.4 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK54990.1 - 3.2e-07 30.6 4.3 0.013 15.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK54990.1 - 1.5e-06 28.2 0.2 0.00067 19.8 0.0 3.2 2 2 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK54990.1 - 0.00028 20.9 0.6 1.5 9.0 0.2 3.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK54990.1 - 0.021 14.9 0.0 1.5 9.0 0.0 2.8 2 1 0 2 2 2 0 Immunoglobulin I-set domain TssO PF17561.2 PIK54991.1 - 0.056 13.6 0.1 0.07 13.2 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO FtsL PF04999.13 PIK54991.1 - 0.06 13.4 0.9 0.11 12.5 0.9 1.5 1 1 0 1 1 1 0 Cell division protein FtsL Peptidase_M56 PF05569.11 PIK54991.1 - 0.06 12.5 0.0 0.066 12.4 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF1616 PF07760.11 PIK54991.1 - 0.071 12.5 0.1 0.077 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) DUF4446 PF14584.6 PIK54991.1 - 0.081 12.9 0.3 0.081 12.9 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Mycobact_memb PF05423.13 PIK54991.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Mycobacterium membrane protein A_deaminase PF00962.22 PIK54992.1 - 1.4e-06 27.9 0.0 1.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase APOBEC_C PF05240.14 PIK54992.1 - 0.012 15.6 0.2 0.021 14.8 0.2 1.4 1 1 0 1 1 1 0 APOBEC-like C-terminal domain APOBEC2 PF18772.1 PIK54992.1 - 0.032 14.3 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 PIK54992.1 - 0.095 12.8 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 ATP-synt_Eps PF04627.13 PIK54992.1 - 1.9 8.5 5.1 6.9 6.7 0.5 2.4 2 1 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain Hydrolase_6 PF13344.6 PIK54994.1 - 3.9e-28 97.5 0.0 7.9e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK54994.1 - 5.6e-19 68.0 0.0 1.1e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 PIK54994.1 - 1.9e-12 47.9 0.0 2.5e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK54994.1 - 1e-08 35.5 0.1 5.1e-06 26.7 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 PIK54994.1 - 0.043 13.4 0.1 0.3 10.7 0.0 2.4 3 0 0 3 3 3 0 Mitochondrial PGP phosphatase Avl9 PF09794.9 PIK54994.1 - 0.091 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Transport protein Avl9 Kazal_2 PF07648.15 PIK54995.1 - 9.1e-12 44.9 15.0 8.4e-06 25.8 2.7 2.4 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK54995.1 - 1.9e-10 40.6 10.6 7.8e-07 29.0 2.5 2.5 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain p450 PF00067.22 PIK54996.1 - 5.9e-94 315.4 0.0 1.9e-93 313.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 U1snRNP70_N PF12220.8 PIK54997.1 - 1.6e-21 76.8 1.1 2.9e-21 75.9 0.8 1.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 PIK54997.1 - 1.3e-14 53.7 0.0 2.2e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK54997.1 - 0.027 14.6 0.0 0.061 13.5 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif YLP PF02757.17 PIK54997.1 - 1.5 9.0 6.5 16 5.9 1.6 2.8 2 0 0 2 2 2 0 YLP motif RhoGEF PF00621.20 PIK55000.1 - 2e-43 148.8 0.0 7.7e-43 146.8 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 PIK55000.1 - 1.5e-06 28.6 0.0 1e-05 26.0 0.0 2.4 3 0 0 3 3 3 1 PH domain PH_13 PF16652.5 PIK55000.1 - 0.0025 17.6 0.0 0.0096 15.7 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Sulfotransfer_2 PF03567.14 PIK55001.1 - 2.8e-09 37.3 0.2 4.1e-09 36.7 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase family SF3b10 PF07189.11 PIK55001.1 - 0.043 13.9 0.1 0.081 13.0 0.1 1.4 1 0 0 1 1 1 0 Splicing factor 3B subunit 10 (SF3b10) Sulfotransfer_1 PF00685.27 PIK55002.1 - 8.9e-63 212.3 1.3 1.1e-62 212.0 1.3 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK55002.1 - 4.9e-08 33.6 0.8 0.0002 21.8 0.0 2.6 3 0 0 3 3 3 2 Sulfotransferase family SpoVIF PF14069.6 PIK55002.1 - 0.03 14.1 0.1 0.065 13.0 0.1 1.6 1 0 0 1 1 1 0 Stage VI sporulation protein F Laminin_EGF PF00053.24 PIK55003.1 - 2.9 8.1 23.5 7.5 6.8 5.5 2.9 1 1 1 2 2 2 0 Laminin EGF domain Frag1 PF10277.9 PIK55005.1 - 3.8e-22 78.9 4.6 3.8e-22 78.9 4.6 1.8 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family ThrE PF06738.12 PIK55005.1 - 0.31 10.4 7.1 0.52 9.6 7.1 1.3 1 0 0 1 1 1 0 Putative threonine/serine exporter Pox_A14 PF05767.12 PIK55005.1 - 0.78 9.9 4.3 0.37 11.0 0.9 2.2 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 ANAPC4_WD40 PF12894.7 PIK55006.1 - 0.00058 20.1 0.1 0.098 13.0 0.1 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK55006.1 - 0.019 15.8 0.9 0.92 10.5 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat WD40_like PF17005.5 PIK55006.1 - 0.023 14.1 0.2 0.17 11.2 0.2 2.1 1 1 0 1 1 1 0 WD40-like domain Peptidase_S8 PF00082.22 PIK55008.1 - 1.7e-33 116.2 17.3 1.7e-33 116.2 17.3 2.0 1 1 1 2 2 2 1 Subtilase family CUB PF00431.20 PIK55008.1 - 6.3e-15 55.5 0.0 1.1e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 CUB domain Inhibitor_I9 PF05922.16 PIK55008.1 - 4e-08 33.8 0.2 6.7e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Caprin-1_dimer PF18293.1 PIK55010.1 - 1.3e-34 119.1 0.6 2.5e-34 118.2 0.6 1.5 1 0 0 1 1 1 1 Caprin-1 dimerization domain zf-CSL PF05207.13 PIK55011.1 - 2e-08 33.8 6.2 4.8e-08 32.6 6.2 1.7 1 1 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 PIK55011.1 - 2.7e-06 27.4 0.1 4.2e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Phos_pyr_kin PF08543.12 PIK55011.1 - 0.22 10.9 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase TILa PF12714.7 PIK55012.1 - 3.1e-07 30.2 11.8 3.1e-07 30.2 11.8 2.5 1 1 1 2 2 2 1 TILa domain Fibrinogen_C PF00147.18 PIK55012.1 - 0.00032 20.6 0.0 0.00055 19.8 0.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK55012.1 - 0.00051 20.2 15.4 0.00051 20.2 15.4 3.7 3 1 1 4 4 4 1 EGF domain TIL PF01826.17 PIK55012.1 - 0.003 17.8 1.5 0.003 17.8 1.5 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 PIK55012.1 - 0.075 13.0 3.1 0.075 13.0 3.1 4.5 4 1 0 4 4 4 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK55013.1 - 5.1e-18 65.7 0.6 6.1e-18 65.4 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Pkinase PF00069.25 PIK55014.1 - 1.4e-51 175.4 0.0 2.6e-51 174.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55014.1 - 8.4e-26 90.8 0.0 1.5e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase P33MONOX PF15302.6 PIK55014.1 - 0.04 13.6 3.7 0.63 9.7 0.1 2.4 2 0 0 2 2 2 0 P33 mono-oxygenase SH3_9 PF14604.6 PIK55016.1 - 1.1e-11 44.4 0.0 2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK55016.1 - 5.4e-07 29.1 0.1 2.7e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 PIK55016.1 - 0.001 18.7 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain YopX PF09643.10 PIK55016.1 - 0.25 11.4 2.5 0.44 10.6 0.2 2.6 2 0 0 2 2 2 0 YopX protein WW PF00397.26 PIK55017.1 - 1.5e-16 60.1 16.0 1.9e-08 34.2 4.5 2.7 2 0 0 2 2 2 2 WW domain TPR_1 PF00515.28 PIK55019.1 - 1.4e-44 148.1 41.1 1.3e-05 24.8 0.8 13.8 14 0 0 14 14 13 8 Tetratricopeptide repeat TPR_2 PF07719.17 PIK55019.1 - 7.4e-41 135.0 44.9 0.00014 21.7 0.0 15.1 15 0 0 15 15 14 9 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55019.1 - 1.5e-34 115.3 36.4 0.00014 21.8 0.3 13.3 14 0 0 14 14 12 7 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55019.1 - 1e-31 106.9 15.5 0.0016 19.1 0.1 13.2 6 4 8 14 14 14 8 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55019.1 - 7.9e-30 103.2 16.5 0.00013 22.4 0.3 10.8 6 4 6 13 13 13 9 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55019.1 - 1.2e-27 96.0 34.2 9.5e-09 35.4 2.6 9.3 7 3 3 10 10 9 8 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55019.1 - 4.1e-25 88.2 10.9 0.011 16.4 0.0 9.6 8 1 2 10 10 10 7 Tetratricopeptide repeat TPR_6 PF13174.6 PIK55019.1 - 2.5e-20 71.7 29.8 0.15 12.8 0.0 12.6 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_17 PF13431.6 PIK55019.1 - 1.4e-18 65.8 38.7 0.051 14.0 0.0 15.8 17 1 1 18 18 16 4 Tetratricopeptide repeat TPR_7 PF13176.6 PIK55019.1 - 2.8e-18 64.5 29.2 0.0038 17.2 0.2 11.4 12 1 0 12 12 9 5 Tetratricopeptide repeat TPR_10 PF13374.6 PIK55019.1 - 1.1e-16 60.1 25.3 0.0016 18.2 0.4 11.7 12 0 0 12 12 11 4 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55019.1 - 3.5e-16 58.6 28.8 9.6e-05 22.0 0.0 12.6 11 3 2 13 13 13 3 TPR repeat ANAPC3 PF12895.7 PIK55019.1 - 6.7e-10 39.1 30.0 0.03 14.5 3.2 7.6 8 1 0 8 8 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK55019.1 - 7.9e-07 29.1 6.5 1.9 8.7 0.0 6.9 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK55019.1 - 4.1e-06 26.4 9.2 0.024 14.0 0.0 4.6 5 1 1 6 6 6 2 MalT-like TPR region PknG_TPR PF16918.5 PIK55019.1 - 4.4e-06 25.6 0.4 0.18 10.5 0.0 3.5 3 0 0 3 3 3 2 Protein kinase G tetratricopeptide repeat TPPII_N PF12583.8 PIK55019.1 - 0.00017 22.2 0.5 0.49 11.0 0.0 4.0 3 1 1 4 4 3 1 Tripeptidyl peptidase II N terminal SNAP PF14938.6 PIK55019.1 - 0.002 17.6 0.5 0.002 17.6 0.5 4.6 3 2 0 4 4 4 1 Soluble NSF attachment protein, SNAP Herpes_IE1 PF07340.11 PIK55019.1 - 0.036 13.0 0.1 0.062 12.2 0.1 1.3 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein RPN7 PF10602.9 PIK55019.1 - 0.13 11.9 5.4 2 8.1 0.1 3.8 3 1 0 3 3 3 0 26S proteasome subunit RPN7 DUF4810 PF16068.5 PIK55019.1 - 0.19 12.3 6.0 2.2 8.9 0.0 5.0 5 1 1 6 6 4 0 Domain of unknown function (DUF4810) SH3_13 PF18335.1 PIK55019.1 - 0.22 11.4 0.7 7 6.6 0.1 2.7 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain SPO22 PF08631.10 PIK55019.1 - 0.23 10.9 13.7 0.45 10.0 0.0 5.3 5 2 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like Fis1_TPR_C PF14853.6 PIK55019.1 - 1.4 9.0 23.3 20 5.4 0.2 7.3 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 PIK55019.1 - 2.5 8.9 10.3 57 4.6 0.2 5.5 5 0 0 5 5 3 0 Sel1 repeat TPR_3 PF07720.12 PIK55019.1 - 2.8 8.0 25.4 10 6.2 4.6 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK55019.1 - 4.3 8.3 9.8 23 6.0 0.3 4.7 6 0 0 6 6 2 0 Tetratricopeptide repeat MAS20 PF02064.15 PIK55019.1 - 5.8 7.0 9.2 0.23 11.5 0.1 3.5 6 1 0 6 6 3 0 MAS20 protein import receptor RT_RNaseH_2 PF17919.1 PIK55020.1 - 2.6e-37 126.8 0.0 4.2e-37 126.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55020.1 - 4.5e-36 123.3 0.0 6e-36 122.9 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4371 PF14291.6 PIK55021.1 - 1.1e-05 25.2 0.2 1.4e-05 24.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) AIG1 PF04548.16 PIK55022.1 - 3.5e-19 69.0 0.2 4.2e-19 68.7 0.2 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK55022.1 - 1.1e-05 25.4 0.0 1.4e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK55022.1 - 0.083 13.0 0.5 4.2 7.4 0.0 2.1 1 1 1 2 2 2 0 Dynamin family GGDEF PF00990.21 PIK55022.1 - 0.16 11.7 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Diguanylate cyclase, GGDEF domain AIG1 PF04548.16 PIK55023.1 - 1.4e-32 112.7 1.5 2e-32 112.3 0.6 1.6 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 PIK55023.1 - 1.1e-08 35.2 0.6 2.6e-08 33.9 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK55023.1 - 3.7e-05 23.8 1.4 0.15 12.2 0.1 2.8 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.18 PIK55023.1 - 0.00032 20.3 0.1 0.0007 19.2 0.1 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK55023.1 - 0.0097 15.8 1.3 0.025 14.5 0.2 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 PIK55023.1 - 0.03 14.1 0.0 0.49 10.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 PIK55023.1 - 0.053 12.9 0.1 0.27 10.5 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 PIK55023.1 - 0.059 12.4 0.6 0.26 10.3 0.2 2.2 1 1 1 2 2 2 0 Type II/IV secretion system protein SRPRB PF09439.10 PIK55023.1 - 0.066 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 PIK55023.1 - 0.072 12.4 0.1 0.35 10.1 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 PIK55023.1 - 0.095 13.0 0.1 0.34 11.2 0.1 1.9 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 PIK55023.1 - 0.53 10.3 2.2 3.9 7.5 0.7 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain RT_RNaseH_2 PF17919.1 PIK55024.1 - 6.2e-37 125.6 0.0 9.8e-37 125.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55024.1 - 2.9e-34 117.5 0.0 4.5e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55024.1 - 6.6e-20 71.6 0.1 1.7e-19 70.3 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flu_PB1 PF00602.17 PIK55024.1 - 0.17 10.0 0.0 0.23 9.5 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 rve PF00665.26 PIK55025.1 - 4.9e-21 75.1 0.0 1.7e-20 73.4 0.0 1.9 3 0 0 3 3 3 1 Integrase core domain 2_5_RNA_ligase2 PF13563.6 PIK55025.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK55025.1 - 0.062 13.1 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain Orthoreo_P10 PF07204.11 PIK55026.1 - 1.5e-05 24.9 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 Shisa PF13908.6 PIK55026.1 - 1.7e-05 25.2 0.2 1.9e-05 25.0 0.2 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator CYYR1 PF10873.8 PIK55026.1 - 0.023 15.1 3.4 0.037 14.5 3.4 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Hum_adeno_E3A PF05393.11 PIK55026.1 - 0.028 14.4 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein LST1 PF05083.13 PIK55026.1 - 0.039 14.2 0.1 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 LST-1 protein EphA2_TM PF14575.6 PIK55026.1 - 0.11 13.4 0.0 0.15 12.9 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMIE PF16038.5 PIK55026.1 - 0.97 9.3 4.6 1.5 8.7 4.6 1.3 1 0 0 1 1 1 0 TMIE protein Bcl-2 PF00452.19 PIK55027.1 - 2.2e-15 57.2 0.1 3.9e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family ARID PF01388.21 PIK55027.1 - 0.08 13.6 0.0 0.72 10.6 0.0 2.2 2 0 0 2 2 2 0 ARID/BRIGHT DNA binding domain Astro_capsid_N PF03115.14 PIK55027.1 - 0.16 10.6 0.1 0.21 10.2 0.1 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor CUB PF00431.20 PIK55028.1 - 2.9e-38 130.6 14.6 1.1e-24 86.8 0.1 6.8 6 1 2 8 8 8 3 CUB domain VirE PF05272.11 PIK55028.1 - 0.008 15.9 1.2 62 3.2 0.0 6.0 4 2 1 7 7 7 0 Virulence-associated protein E COX4_pro PF03626.14 PIK55028.1 - 0.011 16.2 23.6 16 6.0 0.1 8.0 4 2 2 9 9 9 0 Prokaryotic Cytochrome C oxidase subunit IV FOLN PF09289.10 PIK55028.1 - 0.046 13.9 2.5 4.7e+02 1.1 0.0 6.1 6 0 0 6 6 6 0 Follistatin/Osteonectin-like EGF domain Defensin_4 PF07936.12 PIK55028.1 - 0.084 12.8 1.7 0.41 10.6 0.7 2.4 2 0 0 2 2 2 0 Potassium-channel blocking toxin TIR_2 PF13676.6 PIK55029.1 - 3.9e-24 85.5 0.0 3.3e-23 82.5 0.0 2.2 2 0 0 2 2 2 1 TIR domain HEAT_2 PF13646.6 PIK55029.1 - 1.1e-16 60.9 2.9 7.5e-10 39.1 0.5 2.5 1 1 1 2 2 2 2 HEAT repeats TIR PF01582.20 PIK55029.1 - 2.7e-06 27.3 0.1 8.2e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 TIR domain HEAT PF02985.22 PIK55029.1 - 3.7e-05 23.6 2.8 0.4 11.1 0.0 3.6 4 0 0 4 4 4 2 HEAT repeat Cbl_N2 PF02761.14 PIK55029.1 - 0.00045 20.9 2.1 0.0017 19.0 0.4 2.6 3 0 0 3 3 3 1 CBL proto-oncogene N-terminus, EF hand-like domain HEAT_PBS PF03130.16 PIK55029.1 - 0.0013 19.2 0.4 33 5.6 0.0 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 PIK55029.1 - 0.0035 17.8 1.1 0.0098 16.4 0.4 2.2 2 0 0 2 2 2 1 HEAT-like repeat MOR2-PAG1_N PF14222.6 PIK55029.1 - 0.035 13.0 0.2 0.055 12.4 0.2 1.3 1 0 0 1 1 1 0 Cell morphogenesis N-terminal API5 PF05918.11 PIK55029.1 - 0.045 12.6 0.2 0.045 12.6 0.2 2.2 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) Cnd1 PF12717.7 PIK55029.1 - 0.057 13.5 2.0 0.11 12.5 1.2 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 PIK55029.1 - 0.075 13.6 0.6 3.2 8.4 0.1 2.5 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region Phasin PF05597.11 PIK55029.1 - 0.11 12.4 2.1 0.56 10.2 0.1 2.7 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Ets PF00178.22 PIK55030.1 - 1.2 9.6 8.0 5.2 7.6 8.0 2.1 1 0 0 1 1 1 0 Ets-domain DUF4532 PF15046.6 PIK55031.1 - 3.9e-23 82.0 3.0 7.2e-23 81.1 3.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4532) CMAS PF02353.20 PIK55031.1 - 0.063 12.6 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Aldolase_II PF00596.21 PIK55032.1 - 2.9e-28 99.0 0.0 3.8e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Ion_trans PF00520.31 PIK55034.1 - 0.0016 17.8 1.6 0.0017 17.6 1.6 1.0 1 0 0 1 1 1 1 Ion transport protein TMEM192 PF14802.6 PIK55034.1 - 0.016 14.3 1.4 0.017 14.3 1.4 1.0 1 0 0 1 1 1 0 TMEM192 family SLATT_5 PF18160.1 PIK55034.1 - 0.24 10.7 2.2 0.3 10.4 2.2 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Aldolase_II PF00596.21 PIK55035.1 - 4.8e-45 153.8 0.0 5.6e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain RT_RNaseH PF17917.1 PIK55036.1 - 4.4e-38 129.8 0.0 5.9e-38 129.4 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK55036.1 - 2.7e-37 126.8 0.0 3.9e-37 126.3 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PilW PF16074.5 PIK55036.1 - 0.2 11.7 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Type IV Pilus-assembly protein W RT_RNaseH PF17917.1 PIK55037.1 - 1.2e-37 128.4 0.0 1.9e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK55037.1 - 7.7e-37 125.3 0.0 1.2e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55037.1 - 3.7e-12 46.2 0.0 6.4e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK55037.1 - 0.014 14.5 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK55037.1 - 0.14 11.4 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box RVT_1 PF00078.27 PIK55038.1 - 2.7e-31 108.8 0.0 3.6e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SspN PF08177.11 PIK55039.1 - 0.31 11.0 1.3 0.64 10.0 0.4 2.0 2 0 0 2 2 2 0 Small acid-soluble spore protein N family rve PF00665.26 PIK55041.1 - 9.8e-22 77.4 0.0 1.2e-21 77.1 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK55041.1 - 0.0006 19.5 0.1 0.0019 18.0 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK55042.1 - 1e-35 121.8 0.0 2.3e-35 120.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55042.1 - 2.7e-32 111.2 0.0 7.3e-32 109.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55042.1 - 3.1e-24 85.7 0.0 5.5e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1759 PF03564.15 PIK55042.1 - 0.0013 18.6 0.0 0.0033 17.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Troponin PF00992.20 PIK55043.1 - 9.2e-05 22.8 8.1 9.2e-05 22.8 8.1 3.8 1 1 2 3 3 3 1 Troponin Caldesmon PF02029.15 PIK55043.1 - 0.4 9.4 64.0 0.53 9.0 64.0 1.2 1 0 0 1 1 1 0 Caldesmon TIP49_C PF17856.1 PIK55044.1 - 6.8e-28 96.6 0.6 1.1e-27 95.9 0.6 1.4 1 0 0 1 1 1 1 TIP49 AAA-lid domain TIP49 PF06068.13 PIK55044.1 - 1e-09 38.1 0.8 1.6e-09 37.4 0.1 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain TFIID-31kDa PF02291.15 PIK55044.1 - 0.091 12.8 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TIP49 PF06068.13 PIK55045.1 - 1.6e-114 382.8 4.9 3.6e-82 276.4 2.6 2.0 2 0 0 2 2 2 2 TIP49 P-loop domain AAA PF00004.29 PIK55045.1 - 4.7e-07 30.3 0.8 0.00035 21.0 0.1 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 PIK55045.1 - 1.1e-05 24.9 0.2 2e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_19 PF13245.6 PIK55045.1 - 0.00029 21.2 0.8 0.0056 17.0 0.8 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 PIK55045.1 - 0.00042 20.1 0.4 0.02 14.6 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 PIK55045.1 - 0.0026 17.1 0.2 0.0038 16.6 0.2 1.4 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.6 PIK55045.1 - 0.0076 16.7 0.1 0.04 14.3 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK55045.1 - 0.011 15.8 0.2 0.19 11.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 PIK55045.1 - 0.014 15.1 0.1 1 9.0 0.1 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 PIK55045.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain MS_channel PF00924.18 PIK55045.1 - 0.033 13.7 0.4 0.082 12.4 0.1 1.8 1 1 1 2 2 2 0 Mechanosensitive ion channel Zeta_toxin PF06414.12 PIK55045.1 - 0.039 13.2 0.2 0.075 12.3 0.2 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 PIK55045.1 - 0.062 13.6 0.1 6.2 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK55045.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 PIK55045.1 - 0.07 12.6 0.2 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 PIK55045.1 - 0.095 12.1 1.2 0.25 10.7 0.2 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 PIK55045.1 - 0.14 12.1 0.4 0.49 10.4 0.1 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TNFR_c6 PF00020.18 PIK55046.1 - 7.1e-06 26.3 5.9 7.1e-06 26.3 5.9 2.8 2 1 0 2 2 2 1 TNFR/NGFR cysteine-rich region NAD_binding_1 PF00175.21 PIK55048.1 - 4.2e-37 127.1 0.0 7.3e-37 126.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 PIK55048.1 - 8.7e-29 99.8 0.0 1.5e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 PIK55048.1 - 8.3e-06 26.0 0.0 0.00011 22.4 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain UPF0258 PF06789.12 PIK55048.1 - 0.017 15.2 0.1 0.033 14.3 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Tetraspanin PF00335.20 PIK55049.1 - 1.4e-11 44.6 0.1 1.8e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Tetraspanin family 7tm_1 PF00001.21 PIK55050.1 - 2.7e-36 125.2 14.8 3.7e-36 124.8 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55050.1 - 2.6e-09 37.1 18.8 5.1e-09 36.1 18.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_2 PF00002.24 PIK55050.1 - 0.0011 18.3 12.4 0.011 15.1 12.4 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7TM_GPCR_Srsx PF10320.9 PIK55050.1 - 0.0098 15.3 16.9 0.011 15.1 7.4 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.15 PIK55050.1 - 0.017 15.1 2.5 0.017 15.1 2.5 3.0 2 2 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa SSF PF00474.17 PIK55051.1 - 2.9e-11 42.9 1.7 4.5e-11 42.3 1.7 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family Phage_holin_3_3 PF16083.5 PIK55051.1 - 0.036 14.2 9.7 0.061 13.4 1.1 3.7 3 0 0 3 3 3 0 LydA holin phage, holin superfamily III DUF5489 PF17592.2 PIK55051.1 - 0.19 12.3 0.0 0.19 12.3 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5489) adh_short PF00106.25 PIK55052.1 - 3e-06 26.8 0.0 5.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK55052.1 - 0.0011 18.6 0.0 0.0028 17.2 0.0 1.6 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase HNOB PF07700.15 PIK55053.1 - 1.6e-56 190.8 0.4 2e-56 190.5 0.4 1.1 1 0 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.14 PIK55053.1 - 8.2e-05 22.1 0.1 0.00012 21.6 0.1 1.3 1 0 0 1 1 1 1 Heme NO binding associated Guanylate_cyc PF00211.20 PIK55054.1 - 1.2e-62 210.8 0.4 1.9e-62 210.2 0.4 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK55054.1 - 2.8e-46 157.7 3.9 4.1e-46 157.2 3.9 1.3 1 0 0 1 1 1 1 Heme NO binding associated DUF3071 PF11268.8 PIK55054.1 - 0.013 15.5 0.2 0.026 14.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Sec20 PF03908.13 PIK55054.1 - 0.52 10.3 2.1 1.1 9.2 2.1 1.5 1 0 0 1 1 1 0 Sec20 Peptidase_M20 PF01546.28 PIK55056.1 - 1.8e-37 129.1 0.0 2.7e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 PIK55056.1 - 1.2e-14 54.1 0.0 2.1e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 PIK55056.1 - 0.03 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 Gln-synt_C PF00120.24 PIK55057.1 - 1.5e-63 214.9 0.0 1.9e-63 214.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Mito_carr PF00153.27 PIK55058.1 - 1.7e-25 88.7 0.2 1.2e-13 50.7 0.1 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein DEAD PF00270.29 PIK55059.1 - 1.6e-44 151.8 0.0 2.6e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK55059.1 - 4.1e-25 88.3 0.0 1.2e-24 86.8 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPRY PF00622.28 PIK55059.1 - 6.3e-11 42.4 0.1 1.4e-10 41.3 0.1 1.6 1 0 0 1 1 1 1 SPRY domain RVT_2 PF07727.14 PIK55059.1 - 0.025 14.2 0.0 0.16 11.6 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) CMS1 PF14617.6 PIK55059.1 - 0.029 13.7 0.2 0.13 11.5 0.0 2.1 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit ATG101 PF07855.12 PIK55063.1 - 5.1e-36 124.0 0.4 7.2e-36 123.5 0.4 1.2 1 0 0 1 1 1 1 Autophagy-related protein 101 NACHT PF05729.12 PIK55064.1 - 3.3e-17 62.9 0.0 7.4e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain V-set PF07686.17 PIK55064.1 - 1e-09 38.5 0.9 0.0003 20.9 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK55064.1 - 5.7e-08 33.2 5.7 0.15 12.7 0.0 4.9 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK55064.1 - 1.8e-07 31.2 1.2 0.12 12.6 0.0 4.3 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.6 PIK55064.1 - 5.9e-06 26.5 2.5 0.23 11.8 0.0 4.7 4 1 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK55064.1 - 6.3e-06 26.2 2.3 0.018 15.1 0.1 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain NB-ARC PF00931.22 PIK55064.1 - 0.0006 19.1 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 PIK55064.1 - 0.0053 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 PIK55064.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK55064.1 - 0.1 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK55064.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain SCAN PF02023.17 PIK55067.1 - 3.9e-15 55.5 0.4 7.4e-15 54.5 0.4 1.5 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK55067.1 - 0.00099 19.3 2.3 0.0099 16.1 0.2 3.1 3 1 1 4 4 4 1 Retrotransposon gag protein APP_E2 PF12925.7 PIK55067.1 - 0.11 12.2 2.1 1.7 8.3 0.1 2.2 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein rve PF00665.26 PIK55069.1 - 8.2e-13 48.6 0.0 1.7e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK55069.1 - 7.8e-05 22.4 0.5 0.007 16.1 0.0 3.1 3 0 0 3 3 3 1 Integrase core domain ATG11 PF10377.9 PIK55069.1 - 0.0013 18.8 0.1 0.0019 18.2 0.1 1.3 1 0 0 1 1 1 1 Autophagy-related protein 11 FAD_binding_8 PF08022.12 PIK55069.1 - 0.0095 16.0 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain ResIII PF04851.15 PIK55069.1 - 0.011 15.7 0.1 0.018 15.1 0.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MLVIN_C PF18697.1 PIK55069.1 - 0.017 15.2 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DFF40 PF09230.10 PIK55070.1 - 6.1e-62 209.2 9.0 8.4e-62 208.7 9.0 1.2 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa CIDE-N PF02017.15 PIK55070.1 - 3.3e-15 55.8 0.6 1.6e-14 53.7 0.1 2.1 2 0 0 2 2 2 1 CIDE-N domain L27_1 PF09058.10 PIK55070.1 - 0.085 12.8 0.3 3.4 7.7 0.0 2.6 2 0 0 2 2 2 0 L27_1 DUF3417 PF11897.8 PIK55070.1 - 0.13 12.8 1.7 0.48 10.9 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3417) HPS3_C PF14763.6 PIK55071.1 - 1.6e-06 27.7 0.3 2e-06 27.4 0.3 1.1 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal SMC_Nse1 PF07574.13 PIK55071.1 - 0.091 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex HPS3_Mid PF14762.6 PIK55072.1 - 6.2e-44 150.3 3.4 2.8e-42 144.9 3.3 2.6 1 1 0 1 1 1 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.6 PIK55072.1 - 4e-22 78.8 5.6 4.6e-21 75.3 1.2 2.8 2 1 0 2 2 2 1 Hermansky-Pudlak syndrome 3 AEP1 PF17049.5 PIK55073.1 - 0.051 12.6 0.0 0.053 12.6 0.0 1.0 1 0 0 1 1 1 0 ATPase expression protein 1 Pas_Saposin PF09016.10 PIK55073.1 - 0.072 13.4 0.0 0.098 13.0 0.0 1.3 1 0 0 1 1 1 0 Pas factor saposin fold Snf7 PF03357.21 PIK55073.1 - 0.095 12.3 0.2 0.091 12.4 0.2 1.1 1 0 0 1 1 1 0 Snf7 ABC_tran PF00005.27 PIK55074.1 - 1.3e-45 155.3 0.6 9.2e-22 78.0 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 PIK55074.1 - 4.3e-21 74.8 3.9 4.3e-21 74.8 3.9 2.2 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 PIK55074.1 - 1.8e-18 67.4 0.1 0.00033 20.5 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK55074.1 - 1.5e-13 50.7 0.1 0.00066 19.2 0.0 3.7 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK55074.1 - 1e-08 35.3 0.2 0.0011 18.8 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 PIK55074.1 - 8.2e-07 28.7 0.5 0.0071 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 PIK55074.1 - 1.5e-06 28.2 0.1 0.034 14.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase NB-ARC PF00931.22 PIK55074.1 - 2.3e-06 27.0 0.0 0.0095 15.1 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_16 PF13191.6 PIK55074.1 - 3.1e-06 27.7 0.3 0.025 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 PIK55074.1 - 4.9e-06 26.5 0.8 0.0075 16.2 0.0 2.8 2 1 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 PIK55074.1 - 7e-06 26.3 0.5 0.029 14.6 0.0 3.1 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 PIK55074.1 - 1e-05 26.1 0.2 0.035 14.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 PIK55074.1 - 1.6e-05 24.9 0.1 0.032 14.3 0.0 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 PIK55074.1 - 2.8e-05 24.7 13.3 0.002 18.7 0.1 3.9 5 0 0 5 5 3 2 AAA domain Roc PF08477.13 PIK55074.1 - 0.00011 22.4 0.4 0.15 12.3 0.0 3.0 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 PIK55074.1 - 0.00013 22.2 0.3 0.17 12.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 PIK55074.1 - 0.00044 20.0 0.0 0.14 11.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 PIK55074.1 - 0.00096 19.6 0.1 2.5 8.6 0.0 3.4 3 1 1 4 4 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 PIK55074.1 - 0.0014 19.0 0.0 1.4 9.4 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 PIK55074.1 - 0.0016 18.2 0.0 1.5 8.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain PduV-EutP PF10662.9 PIK55074.1 - 0.0019 18.0 0.1 1.2 8.8 0.1 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 PIK55074.1 - 0.0021 18.1 0.0 0.064 13.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 PIK55074.1 - 0.0021 17.6 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 PIK55074.1 - 0.0025 18.0 1.4 2.8 8.1 0.0 3.4 3 1 1 4 4 3 1 AAA domain NTPase_1 PF03266.15 PIK55074.1 - 0.0026 17.7 0.1 1.5 8.7 0.0 3.2 3 1 1 4 4 3 1 NTPase AAA_14 PF13173.6 PIK55074.1 - 0.0037 17.3 0.5 6.8 6.7 0.0 3.4 3 1 1 4 4 4 0 AAA domain Arf PF00025.21 PIK55074.1 - 0.0038 16.7 0.2 0.42 10.0 0.0 3.3 3 0 0 3 3 3 1 ADP-ribosylation factor family DUF87 PF01935.17 PIK55074.1 - 0.0041 17.3 3.1 0.1 12.7 0.0 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain cobW PF02492.19 PIK55074.1 - 0.0052 16.4 0.9 2.4 7.7 0.1 3.2 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 PIK55074.1 - 0.0052 16.1 0.1 0.1 11.9 0.0 2.5 3 0 0 3 3 2 1 Zeta toxin MobB PF03205.14 PIK55074.1 - 0.0091 15.9 0.1 0.29 11.0 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 PIK55074.1 - 0.011 15.7 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_13 PF13166.6 PIK55074.1 - 0.013 14.1 10.7 0.16 10.6 0.0 3.7 3 1 1 4 4 4 0 AAA domain ATPase_2 PF01637.18 PIK55074.1 - 0.014 15.3 2.2 5.6 6.8 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ATP-synt_ab PF00006.25 PIK55074.1 - 0.016 14.9 0.0 4.7 6.8 0.0 2.5 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MCM PF00493.23 PIK55074.1 - 0.029 13.4 0.1 0.46 9.5 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain Septin PF00735.18 PIK55074.1 - 0.05 12.9 0.7 4.3 6.5 0.0 2.6 3 0 0 3 3 2 0 Septin T2SSE PF00437.20 PIK55074.1 - 0.05 12.6 0.0 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.6 PIK55074.1 - 0.064 13.5 0.8 17 5.8 0.1 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Sigma54_activat PF00158.26 PIK55074.1 - 0.067 12.9 0.0 3.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain G-alpha PF00503.20 PIK55074.1 - 0.07 12.3 1.6 0.39 9.8 0.0 2.3 2 1 0 2 2 2 0 G-protein alpha subunit AAA_17 PF13207.6 PIK55074.1 - 0.18 12.2 1.2 26 5.2 0.0 3.1 3 0 0 3 3 2 0 AAA domain Dynamin_N PF00350.23 PIK55074.1 - 0.39 10.8 1.8 9.5 6.2 0.0 3.1 3 1 0 3 3 3 0 Dynamin family Galactosyl_T PF01762.21 PIK55075.1 - 8.3e-33 113.9 0.2 1.5e-32 113.0 0.2 1.4 1 0 0 1 1 1 1 Galactosyltransferase Bin3 PF06859.12 PIK55076.1 - 3.6e-42 143.4 0.2 6.7e-42 142.5 0.1 1.5 2 0 0 2 2 2 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_31 PF13847.6 PIK55077.1 - 4e-07 30.0 0.0 1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK55077.1 - 1.5e-06 28.8 0.0 3.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK55077.1 - 2.4e-06 27.5 0.0 4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK55077.1 - 6.7e-06 26.8 0.0 2.4e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK55077.1 - 4.7e-05 24.0 0.0 0.00011 22.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 PIK55077.1 - 5.1e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK55077.1 - 0.00064 19.3 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK55077.1 - 0.0036 16.8 0.0 0.011 15.2 0.0 1.8 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 PIK55077.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 PIK55077.1 - 0.017 14.4 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 PIK55077.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 PIK55077.1 - 0.07 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 PIK55077.1 - 0.14 12.2 0.2 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain PWWP PF00855.17 PIK55078.1 - 6.3e-14 52.1 0.4 2e-13 50.6 0.4 1.8 1 0 0 1 1 1 1 PWWP domain zf-CW PF07496.15 PIK55078.1 - 3.3e-13 49.4 7.4 3.3e-13 49.4 7.4 2.2 2 0 0 2 2 2 1 CW-type Zinc Finger RT_RNaseH_2 PF17919.1 PIK55080.1 - 1.1e-34 118.4 0.0 2.2e-34 117.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55080.1 - 4.2e-30 104.1 0.0 7.3e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55080.1 - 7.9e-30 104.0 0.0 1.2e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.14 PIK55080.1 - 0.12 12.2 0.0 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase thumb domain FXa_inhibition PF14670.6 PIK55081.1 - 2.8e-33 113.9 103.4 2.3e-09 37.3 12.0 15.2 10 2 3 13 13 13 6 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK55081.1 - 5.7e-25 86.9 47.4 1.4e-08 34.5 1.5 16.9 17 0 0 17 17 17 9 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK55081.1 - 2e-20 72.7 88.9 3.2e-08 33.6 9.6 14.3 11 2 2 13 13 13 6 Calcium-binding EGF domain EGF PF00008.27 PIK55081.1 - 4.1e-05 23.8 216.4 0.0072 16.6 7.9 17.3 13 3 2 15 15 15 10 EGF-like domain Laminin_EGF PF00053.24 PIK55081.1 - 0.00029 20.9 16.0 0.00029 20.9 16.0 14.1 3 2 8 11 11 11 4 Laminin EGF domain EGF_2 PF07974.13 PIK55081.1 - 0.0015 18.9 11.8 0.0015 18.9 11.8 18.2 11 3 3 14 14 14 3 EGF-like domain hEGF PF12661.7 PIK55081.1 - 0.0079 16.8 22.3 0.016 15.8 10.6 18.3 19 2 0 19 19 19 6 Human growth factor-like EGF Laminin_EGF PF00053.24 PIK55082.1 - 2.8e-16 59.4 114.5 0.00037 20.6 14.1 6.7 3 2 4 7 7 7 5 Laminin EGF domain EGF_2 PF07974.13 PIK55082.1 - 1.2e-08 35.2 134.5 0.001 19.4 16.4 10.9 8 4 1 9 9 9 6 EGF-like domain hEGF PF12661.7 PIK55082.1 - 0.0019 18.7 19.7 0.0077 16.8 9.2 9.7 10 2 1 11 11 11 4 Human growth factor-like EGF Asp_protease PF09668.10 PIK55082.1 - 0.32 10.8 2.2 0.25 11.1 0.3 1.7 2 0 0 2 2 2 0 Aspartyl protease Ig_3 PF13927.6 PIK55083.1 - 3.1e-07 30.9 0.1 0.026 15.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK55083.1 - 9.7e-06 25.8 0.5 0.28 11.5 0.0 2.7 2 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK55083.1 - 0.00033 20.8 0.5 0.2 11.9 0.3 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK55083.1 - 0.00042 20.5 0.0 0.88 9.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 PIK55083.1 - 0.0024 17.9 0.0 0.1 12.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain PRA1 PF03208.19 PIK55083.1 - 0.011 15.3 0.2 0.021 14.5 0.2 1.4 1 0 0 1 1 1 0 PRA1 family protein UL41A PF17591.2 PIK55083.1 - 0.076 13.1 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL41A DUF3119 PF11317.8 PIK55083.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) Ycf70 PF17382.2 PIK55083.1 - 0.17 12.3 0.1 0.32 11.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized Ycf70-like IgGFc_binding PF17517.2 PIK55084.1 - 1e-16 61.1 0.6 1e-15 57.8 0.2 2.3 1 1 1 2 2 2 1 IgGFc binding protein ING PF12998.7 PIK55085.1 - 1.3e-18 67.4 1.4 1.3e-18 67.4 1.4 1.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding Folliculin PF11704.8 PIK55085.1 - 0.065 13.1 2.2 0.069 13.0 1.4 1.4 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport SpmSyn_N PF17950.1 PIK55085.1 - 0.11 12.7 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Casc1 PF12366.8 PIK55085.1 - 0.23 10.9 3.9 0.11 12.0 1.9 1.4 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 YlqD PF11068.8 PIK55085.1 - 1.2 9.5 8.9 5.6 7.4 5.1 2.2 1 1 1 2 2 2 0 YlqD protein DUF4407 PF14362.6 PIK55085.1 - 7.9 5.7 9.0 27 4.0 9.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Rer1 PF03248.13 PIK55086.1 - 8.5e-71 237.2 6.9 1.3e-70 236.6 6.9 1.3 1 0 0 1 1 1 1 Rer1 family Imm65 PF15582.6 PIK55086.1 - 0.028 13.3 0.1 0.04 12.8 0.1 1.1 1 0 0 1 1 1 0 Immunity protein 65 IncFII_repA PF02387.15 PIK55086.1 - 0.14 11.4 0.3 0.19 10.9 0.3 1.1 1 0 0 1 1 1 0 IncFII RepA protein family Nuc_sug_transp PF04142.15 PIK55087.1 - 5e-08 32.5 0.5 1.1e-07 31.4 0.5 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 PIK55087.1 - 1.6e-07 31.6 26.4 4.3e-06 26.9 9.4 3.8 3 2 1 4 4 4 2 EamA-like transporter family SLC35F PF06027.12 PIK55087.1 - 3.7e-07 30.0 6.1 1.4e-06 28.1 5.0 2.3 2 1 0 2 2 2 1 Solute carrier family 35 CRT-like PF08627.10 PIK55087.1 - 5e-06 25.7 6.6 1.1e-05 24.6 6.6 1.7 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 PIK55087.1 - 5.2e-06 25.9 3.3 7.8e-06 25.3 3.3 1.3 1 0 0 1 1 1 1 UAA transporter family DUF4131 PF13567.6 PIK55087.1 - 0.021 14.5 0.9 0.021 14.5 0.9 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) TIM PF00121.18 PIK55088.1 - 7.9e-90 300.5 0.9 8.9e-90 300.3 0.9 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase UCH PF00443.29 PIK55089.1 - 2.2e-11 43.8 10.6 2.2e-11 43.8 10.6 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RAP80_UIM PF18282.1 PIK55089.1 - 0.003 17.3 0.1 0.003 17.3 0.1 3.5 3 1 0 3 3 3 1 RAP80 N-terminal ubiquitin interaction motif UCH_1 PF13423.6 PIK55089.1 - 0.015 14.9 7.8 0.041 13.5 7.8 1.7 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 PIK55089.1 - 0.022 14.7 0.1 0.022 14.7 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin interaction motif DUF2371 PF10177.9 PIK55090.1 - 0.2 11.9 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) UPF0515 PF15135.6 PIK55091.1 - 6.7e-29 101.1 12.9 1.1e-28 100.4 12.9 1.3 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC_2 PF17180.4 PIK55091.1 - 0.026 15.3 14.2 0.071 13.9 1.2 2.7 1 1 1 2 2 2 0 Zinc-binding domain PAW PF04721.17 PIK55092.1 - 2.2e-56 190.8 6.9 3.3e-56 190.2 2.9 2.2 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.10 PIK55092.1 - 6.6e-22 77.2 0.1 1.7e-21 76.0 0.1 1.6 1 0 0 1 1 1 1 PUB domain Rad4 PF03835.15 PIK55092.1 - 1.6e-12 47.3 1.2 3.8e-12 46.1 1.2 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 PIK55092.1 - 3.4e-12 46.8 1.4 7.7e-12 45.7 1.4 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Lectin_C PF00059.21 PIK55093.1 - 1.2e-10 42.1 1.4 1.7e-10 41.6 1.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain SUKH_6 PF14568.6 PIK55093.1 - 0.037 14.5 3.3 0.037 14.4 1.6 1.8 1 1 0 2 2 2 0 SMI1-KNR4 cell-wall UL45 PF05473.12 PIK55093.1 - 0.083 12.5 0.3 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Pkinase PF00069.25 PIK55094.1 - 8e-19 68.0 0.0 4.2e-18 65.7 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55094.1 - 1.2e-09 37.8 0.0 4.2e-07 29.5 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 PIK55094.1 - 0.0037 17.2 0.0 0.012 15.6 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK55094.1 - 0.0089 15.6 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 PIK55094.1 - 0.23 10.4 0.1 0.38 9.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF948 PF06103.11 PIK55094.1 - 0.38 11.0 3.4 2.5 8.4 0.3 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 PIK55094.1 - 3.3 8.0 4.7 33 4.8 0.8 3.1 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Myosin_tail_1 PF01576.19 PIK55095.1 - 0.0001 20.3 54.6 0.00014 19.9 54.6 1.1 1 0 0 1 1 1 1 Myosin tail ERM PF00769.19 PIK55095.1 - 0.00013 21.9 64.2 0.0018 18.2 25.1 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family GAS PF13851.6 PIK55095.1 - 0.00024 20.5 58.9 0.0089 15.4 31.1 2.6 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 PIK55095.1 - 0.059 13.6 60.6 0.53 10.5 31.7 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HIP1_clath_bdg PF16515.5 PIK55095.1 - 0.15 12.7 58.0 0.13 12.9 22.9 3.4 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4472 PF14739.6 PIK55095.1 - 0.17 12.7 50.9 0.11 13.3 16.1 4.2 1 1 2 4 4 4 0 Domain of unknown function (DUF4472) TPD52 PF04201.15 PIK55095.1 - 0.22 11.1 39.8 0.32 10.6 7.7 3.8 1 1 2 3 3 3 0 Tumour protein D52 family APG6_N PF17675.1 PIK55095.1 - 0.22 12.1 69.1 2 9.0 23.1 3.3 1 1 1 2 2 2 0 Apg6 coiled-coil region CALCOCO1 PF07888.11 PIK55095.1 - 0.23 10.3 51.2 0.3 9.9 51.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TACC_C PF05010.14 PIK55095.1 - 0.51 10.1 47.2 9.2 6.0 46.5 2.1 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FPP PF05911.11 PIK55095.1 - 0.73 7.9 44.9 0.27 9.4 4.2 3.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 PIK55095.1 - 1.5 7.6 55.3 1.1 8.0 25.5 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4806 PF16064.5 PIK55095.1 - 1.7 9.0 12.7 9.2 6.6 0.4 3.7 1 1 4 5 5 5 0 Domain of unknown function (DUF4806) Sipho_Gp157 PF05565.11 PIK55095.1 - 1.9 8.4 41.4 3.5 7.6 11.3 3.4 1 1 1 2 2 2 0 Siphovirus Gp157 SKA2 PF16740.5 PIK55095.1 - 2 8.2 39.3 0.035 13.9 5.4 4.1 1 1 3 4 4 4 0 Spindle and kinetochore-associated protein 2 KASH_CCD PF14662.6 PIK55095.1 - 2.2 8.1 55.7 0.69 9.7 24.3 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DinB_2 PF12867.7 PIK55095.1 - 3 8.4 10.3 1.6e+03 -0.5 10.3 3.1 1 1 0 1 1 1 0 DinB superfamily PilA4 PF18682.1 PIK55095.1 - 3.3 8.2 7.0 13 6.2 0.8 3.8 1 1 3 4 4 4 0 Pilin A4 FliT PF05400.13 PIK55095.1 - 4.5 8.2 39.9 32 5.4 15.8 4.6 1 1 2 3 3 2 0 Flagellar protein FliT DUF1664 PF07889.12 PIK55095.1 - 5 7.2 32.5 0.95 9.5 7.1 3.6 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 PIK55095.1 - 6.2 5.8 48.0 1.2 8.2 21.2 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 PIK55095.1 - 6.6 6.1 55.8 1.3 8.4 39.3 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Lebercilin PF15619.6 PIK55095.1 - 6.8 6.3 58.8 0.85 9.2 43.0 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CREPT PF16566.5 PIK55095.1 - 6.9 6.8 38.1 4.3 7.5 15.4 2.9 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4172 PF13776.6 PIK55095.1 - 7.5 7.0 13.5 4.5 7.7 0.7 3.8 1 1 1 3 3 3 0 Domain of unknown function (DUF4172) BAR_3 PF16746.5 PIK55095.1 - 7.6 6.2 35.4 0.32 10.7 22.1 2.8 1 1 1 2 2 2 0 BAR domain of APPL family ZU5 PF00791.20 PIK55096.1 - 1.2e-09 38.4 0.1 2.3e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 ZU5 domain APG6_N PF17675.1 PIK55097.1 - 0.0013 19.3 46.4 0.013 16.0 15.8 2.4 1 1 1 2 2 2 2 Apg6 coiled-coil region GAS PF13851.6 PIK55097.1 - 0.028 13.8 43.4 0.3 10.4 20.0 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK55097.1 - 0.085 12.7 44.4 0.2 11.5 15.3 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4093 PF13331.6 PIK55097.1 - 0.22 12.0 12.1 0.29 11.6 0.5 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4093) CALCOCO1 PF07888.11 PIK55097.1 - 0.36 9.6 34.6 0.63 8.8 34.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3584 PF12128.8 PIK55097.1 - 2 5.8 32.7 3 5.3 32.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FlgN PF05130.12 PIK55097.1 - 2.2 8.8 36.3 1.3 9.5 7.4 3.4 1 1 2 3 3 3 0 FlgN protein Fez1 PF06818.15 PIK55097.1 - 2.8 8.3 33.8 5.7 7.4 33.8 1.5 1 0 0 1 1 1 0 Fez1 CENP-F_leu_zip PF10473.9 PIK55097.1 - 2.9 7.9 42.9 24 5.0 31.1 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GD_N PF16030.5 PIK55097.1 - 3.5 7.9 6.7 6.6 7.1 0.9 2.8 1 1 1 2 2 2 0 Serine protease gd N-terminus Seryl_tRNA_N PF02403.22 PIK55097.1 - 5.6 7.2 33.6 4.5 7.6 15.4 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Macoilin PF09726.9 PIK55097.1 - 7.5 5.0 24.4 10 4.6 24.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF4472 PF14739.6 PIK55097.1 - 9.2 7.1 35.9 0.8 10.5 10.9 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) ZU5 PF00791.20 PIK55098.1 - 3.1e-13 49.9 0.0 1.1e-12 48.1 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK55098.1 - 7.1e-05 23.0 3.7 0.12 12.6 1.2 2.5 2 0 0 2 2 2 2 Death effector domain Pkinase PF00069.25 PIK55099.1 - 1.3e-17 64.1 0.0 6.3e-17 61.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55099.1 - 7.1e-09 35.3 0.0 8.2e-06 25.3 0.0 2.5 1 1 2 3 3 3 2 Protein tyrosine kinase APH PF01636.23 PIK55099.1 - 0.00086 19.3 0.0 0.0045 16.9 0.0 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK55099.1 - 0.0033 17.0 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 PIK55099.1 - 0.041 13.2 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like GAS PF13851.6 PIK55100.1 - 0.00035 20.0 28.5 0.00035 20.0 28.5 2.5 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK55100.1 - 0.0011 18.9 44.0 0.0037 17.1 44.0 1.7 1 1 0 1 1 1 1 Ezrin/radixin/moesin family CALCOCO1 PF07888.11 PIK55100.1 - 0.0027 16.6 29.3 0.0036 16.3 29.3 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like FPP PF05911.11 PIK55100.1 - 0.036 12.3 25.8 0.049 11.8 25.8 1.3 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil HMMR_N PF15905.5 PIK55100.1 - 0.074 12.5 33.2 0.13 11.8 33.2 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Caldesmon PF02029.15 PIK55100.1 - 0.11 11.2 26.0 0.16 10.7 26.0 1.2 1 0 0 1 1 1 0 Caldesmon Sipho_Gp157 PF05565.11 PIK55100.1 - 0.23 11.4 27.5 0.19 11.7 9.8 2.4 1 1 1 2 2 2 0 Siphovirus Gp157 APG6_N PF17675.1 PIK55100.1 - 0.43 11.1 50.8 0.089 13.3 20.4 3.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4472 PF14739.6 PIK55100.1 - 0.5 11.1 35.8 0.059 14.1 15.9 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4472) DUF3584 PF12128.8 PIK55100.1 - 0.67 7.4 32.1 0.97 6.9 32.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Prominin PF05478.11 PIK55100.1 - 1.2 7.0 12.2 1.9 6.4 12.2 1.4 1 0 0 1 1 1 0 Prominin Fez1 PF06818.15 PIK55100.1 - 1.3 9.4 36.9 3.6 8.0 36.9 1.7 1 1 0 1 1 1 0 Fez1 DUF1664 PF07889.12 PIK55100.1 - 1.6 8.8 18.9 2 8.4 10.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 PIK55100.1 - 1.9 7.3 39.4 0.23 10.3 24.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 PIK55100.1 - 2.4 8.0 38.7 4.6 7.0 10.3 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH HBM PF16591.5 PIK55100.1 - 2.4 7.5 26.9 14 5.0 12.5 2.5 1 1 0 2 2 2 0 Helical bimodular sensor domain Lebercilin PF15619.6 PIK55100.1 - 2.6 7.7 42.5 0.099 12.3 14.6 2.8 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TPD52 PF04201.15 PIK55100.1 - 2.8 7.5 27.2 0.091 12.4 7.8 2.8 1 1 1 2 2 2 0 Tumour protein D52 family ATG16 PF08614.11 PIK55100.1 - 3.4 7.8 42.6 19 5.4 42.3 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 PIK55100.1 - 4.5 7.5 39.5 2.8 8.2 27.1 2.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliT PF05400.13 PIK55100.1 - 5 8.0 31.8 1.8 9.4 11.2 3.6 1 1 2 3 3 3 0 Flagellar protein FliT zf-C4H2 PF10146.9 PIK55100.1 - 6 7.1 25.7 17 5.7 25.8 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein Seryl_tRNA_N PF02403.22 PIK55100.1 - 6.2 7.1 32.2 0.21 11.8 14.1 3.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HIP1_clath_bdg PF16515.5 PIK55100.1 - 6.2 7.5 42.1 0.42 11.2 19.2 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4806 PF16064.5 PIK55100.1 - 7.9 6.8 9.3 12 6.3 1.3 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF4806) Sin3_corepress PF08295.12 PIK55100.1 - 8.3 6.6 11.8 14 5.8 1.2 3.3 1 1 2 3 3 3 0 Sin3 family co-repressor CUB PF00431.20 PIK55101.1 - 1e-29 103.1 0.1 1.2e-29 102.9 0.1 1.0 1 0 0 1 1 1 1 CUB domain CUB PF00431.20 PIK55102.1 - 3.3e-25 88.6 0.1 2.1e-12 47.4 0.3 2.0 2 0 0 2 2 2 2 CUB domain CUB PF00431.20 PIK55103.1 - 1.8e-25 89.4 0.0 2e-25 89.2 0.0 1.0 1 0 0 1 1 1 1 CUB domain ZU5 PF00791.20 PIK55104.1 - 2.1e-08 34.4 0.1 4.9e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain Pkinase PF00069.25 PIK55105.1 - 1.5e-30 106.5 0.1 2.8e-30 105.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55105.1 - 4.7e-14 52.3 0.6 9.4e-14 51.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 PIK55105.1 - 0.00082 19.4 0.0 0.0039 17.1 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK55105.1 - 0.00099 18.5 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK55105.1 - 0.0071 16.0 0.0 0.027 14.0 0.0 1.8 1 1 1 2 2 2 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 PIK55105.1 - 0.068 11.9 0.7 0.12 11.1 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase ZU5 PF00791.20 PIK55106.1 - 1.1e-09 38.5 0.0 2.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain UPF0128 PF03673.13 PIK55106.1 - 0.035 13.6 0.2 0.063 12.8 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Transposase_22 PF02994.14 PIK55107.1 - 0.019 15.1 1.4 0.42 10.8 1.2 2.8 1 1 0 1 1 1 0 L1 transposable element RBD-like domain GAS PF13851.6 PIK55107.1 - 0.022 14.1 6.6 0.031 13.6 6.6 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PQQ_3 PF13570.6 PIK55108.1 - 0.1 13.1 0.0 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 PQQ-like domain HPS3_N PF14761.6 PIK55108.1 - 0.19 11.2 0.0 0.94 9.0 0.0 2.1 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 Pkinase PF00069.25 PIK55109.1 - 5.5e-22 78.4 0.1 7.3e-22 78.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55109.1 - 3.2e-10 39.7 0.1 4.4e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK55109.1 - 0.00017 21.6 0.0 0.0026 17.7 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 PIK55109.1 - 0.00026 20.4 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK55109.1 - 0.0042 16.7 0.0 0.011 15.3 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 PIK55109.1 - 0.035 12.9 0.0 0.052 12.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK55109.1 - 0.071 12.1 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ZU5 PF00791.20 PIK55110.1 - 8.4e-14 51.7 0.0 1.9e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain HIP1_clath_bdg PF16515.5 PIK55111.1 - 0.00018 22.0 14.2 0.00018 22.0 14.2 2.9 1 1 1 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 GAS PF13851.6 PIK55111.1 - 0.00066 19.1 43.8 0.006 16.0 26.1 2.6 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK55111.1 - 0.0022 18.5 52.6 0.11 13.0 17.6 3.5 1 1 1 2 2 2 1 Apg6 coiled-coil region ERM PF00769.19 PIK55111.1 - 0.0081 16.0 48.5 0.015 15.2 18.3 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family DUF1495 PF07381.11 PIK55111.1 - 0.046 13.6 0.3 13 5.7 0.0 2.7 3 0 0 3 3 2 0 Winged helix DNA-binding domain (DUF1495) Seryl_tRNA_N PF02403.22 PIK55111.1 - 0.099 12.9 33.7 0.065 13.5 9.9 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SAM_KSR1 PF13543.6 PIK55111.1 - 0.1 12.8 14.3 0.59 10.3 3.1 3.1 2 2 1 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 NAPRTase_N PF17767.1 PIK55111.1 - 0.11 12.9 10.2 2.6 8.5 2.1 2.8 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Mei5 PF10376.9 PIK55111.1 - 0.44 10.4 26.9 3.8 7.3 4.3 2.4 1 1 1 2 2 2 0 Double-strand recombination repair protein CENP-F_leu_zip PF10473.9 PIK55111.1 - 0.56 10.2 44.1 5.9 6.9 24.7 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 PIK55111.1 - 0.6 7.6 33.1 0.91 7.0 33.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) T3SSipB PF16535.5 PIK55111.1 - 0.63 10.5 25.7 0.24 11.8 5.9 2.9 1 1 1 2 2 2 0 Type III cell invasion protein SipB HMMR_N PF15905.5 PIK55111.1 - 0.94 8.9 40.9 8.6 5.7 39.8 2.1 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Med30 PF11315.8 PIK55111.1 - 1.2 9.3 27.1 0.46 10.7 1.0 3.2 1 1 2 3 3 3 0 Mediator complex subunit 30 PilA4 PF18682.1 PIK55111.1 - 1.2 9.5 3.7 3.7 8.0 0.3 3.1 2 2 1 3 3 3 0 Pilin A4 DUF2073 PF09846.9 PIK55111.1 - 1.4 8.8 5.8 1.6 8.6 3.6 2.1 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) Syntaxin-6_N PF09177.11 PIK55111.1 - 1.4 9.5 24.8 1.5 9.4 4.7 3.2 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TMF_TATA_bd PF12325.8 PIK55111.1 - 1.7 8.9 38.7 2.7 8.2 10.8 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Clusterin PF01093.17 PIK55111.1 - 2.4 7.1 27.5 2.2 7.2 14.0 2.8 1 1 1 2 2 2 0 Clusterin Phage_30_3 PF08010.11 PIK55111.1 - 2.7 7.8 8.8 11 5.8 2.4 2.6 1 1 0 2 2 2 0 Bacteriophage protein GP30.3 DUF4472 PF14739.6 PIK55111.1 - 2.9 8.7 34.0 4.8 7.9 9.8 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) KASH_CCD PF14662.6 PIK55111.1 - 2.9 7.7 40.3 4.3 7.1 13.8 2.8 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 PIK55111.1 - 5.4 5.8 39.4 2.8 6.7 3.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein LMBR1 PF04791.16 PIK55111.1 - 6.3 5.6 14.4 8.8 5.1 14.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4726 PF15855.5 PIK55111.1 - 9.1 6.6 16.6 40 4.5 0.1 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4726) CUB PF00431.20 PIK55112.1 - 6.5e-72 238.9 1.1 7.9e-28 97.0 0.1 3.4 3 0 0 3 3 3 3 CUB domain Peptidase_S8 PF00082.22 PIK55112.1 - 2.9e-32 112.1 7.7 5.8e-32 111.2 7.7 1.4 1 0 0 1 1 1 1 Subtilase family CUB_2 PF02408.20 PIK55112.1 - 6.8e-06 25.8 9.2 0.0039 17.0 0.1 3.9 3 1 0 3 3 3 3 CUB-like domain Inhibitor_I9 PF05922.16 PIK55112.1 - 0.0014 19.3 0.0 0.0029 18.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 CUB PF00431.20 PIK55113.1 - 1.5e-105 347.1 6.6 8.4e-29 100.1 0.0 4.2 4 0 0 4 4 4 4 CUB domain Peptidase_S8 PF00082.22 PIK55113.1 - 7.2e-33 114.1 7.9 1.7e-32 112.9 7.9 1.6 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK55113.1 - 1.2e-07 32.3 0.1 2.4e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 CUB_2 PF02408.20 PIK55113.1 - 5.9e-05 22.8 9.8 0.26 11.1 0.5 4.6 4 0 0 4 4 4 2 CUB-like domain GLTP PF08718.11 PIK55114.1 - 3e-24 86.0 0.0 4.2e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) GIY-YIG PF01541.24 PIK55115.1 - 2.3e-05 24.6 0.2 6.3e-05 23.2 0.2 1.8 1 0 0 1 1 1 1 GIY-YIG catalytic domain 7tm_1 PF00001.21 PIK55116.1 - 5.3e-42 144.0 13.3 7.6e-42 143.4 13.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55116.1 - 0.005 16.5 21.3 0.005 16.5 21.3 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Alb1 PF09135.11 PIK55116.1 - 0.047 14.6 1.8 0.073 14.0 1.8 1.2 1 0 0 1 1 1 0 Alb1 YjcB PF15940.5 PIK55116.1 - 1.4 9.1 5.3 3.7 7.8 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function Josephin PF02099.17 PIK55119.1 - 1.9e-21 76.8 6.0 9.7e-20 71.3 0.3 2.9 2 1 1 3 3 3 2 Josephin SUIM_assoc PF16619.5 PIK55119.1 - 0.00016 21.7 0.8 0.00016 21.7 0.8 2.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.20 PIK55119.1 - 0.0093 15.8 20.7 0.36 10.8 2.8 3.5 3 0 0 3 3 3 3 Ubiquitin interaction motif MHB PF16525.5 PIK55119.1 - 0.034 14.4 0.9 0.22 11.8 0.4 2.3 1 1 1 2 2 2 0 Haemophore, haem-binding Ribosomal_S18 PF01084.20 PIK55120.1 - 1.1e-19 70.3 0.1 1.5e-19 69.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S18 Radial_spoke PF04712.12 PIK55121.1 - 2e-14 53.5 0.0 9.6e-08 31.4 0.0 2.2 2 0 0 2 2 2 2 Radial spokehead-like protein Solute_trans_a PF03619.16 PIK55122.1 - 1.6e-33 116.4 19.1 1.9e-33 116.2 19.1 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha tRNA-synt_1c PF00749.21 PIK55123.1 - 6.6e-115 383.3 0.6 1.4e-114 382.3 0.6 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain zf-H2C2_2 PF13465.6 PIK55123.1 - 1.8e-71 233.6 87.9 6.3e-09 35.9 2.3 12.3 12 0 0 12 12 12 10 Zinc-finger double domain WHEP-TRS PF00458.20 PIK55123.1 - 3e-66 219.4 21.1 5.4e-22 77.7 1.5 3.8 3 0 0 3 3 3 3 WHEP-TRS domain zf-C2H2 PF00096.26 PIK55123.1 - 1.1e-33 113.8 83.7 0.00013 22.2 1.5 12.1 11 0 0 11 11 11 9 Zinc finger, C2H2 type tRNA-synt_1c_C PF03950.18 PIK55123.1 - 1.5e-33 116.1 0.1 4.4e-33 114.6 0.1 1.9 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain zf-C2H2_4 PF13894.6 PIK55123.1 - 2.4e-26 90.1 74.4 0.0015 19.2 1.0 11.9 11 0 0 11 11 11 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK55123.1 - 7.8e-19 67.5 34.7 0.02 15.1 0.2 10.3 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding tRNA-synt_2b PF00587.25 PIK55123.1 - 4.5e-18 65.8 0.0 1.8e-17 63.9 0.0 2.0 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 PIK55123.1 - 1.3e-13 50.9 0.0 3.7e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.11 PIK55123.1 - 1.4e-13 50.9 0.6 1.4e-13 50.9 0.6 2.7 2 0 0 2 2 1 1 Prolyl-tRNA synthetase, C-terminal PyrI_C PF02748.15 PIK55123.1 - 2.9e-08 33.5 61.6 0.3 11.0 0.8 11.6 8 2 3 11 11 11 7 Aspartate carbamoyltransferase regulatory chain, metal binding domain Pentapeptide_2 PF01469.18 PIK55123.1 - 0.00021 21.1 17.7 0.018 14.9 5.7 2.4 2 0 0 2 2 2 2 Pentapeptide repeats (8 copies) zf-C2H2_6 PF13912.6 PIK55123.1 - 0.00079 19.4 7.2 0.0068 16.4 1.4 9.7 11 0 0 11 11 9 5 C2H2-type zinc finger Glyco_hydro_2_C PF02836.17 PIK55123.1 - 0.0062 15.7 12.1 2.3 7.3 0.5 4.5 1 1 3 4 4 4 2 Glycosyl hydrolases family 2, TIM barrel domain tRNA-synt_1e PF01406.19 PIK55123.1 - 0.013 14.8 1.5 0.018 14.4 0.1 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF3850 PF12961.7 PIK55123.1 - 0.052 13.6 0.0 6.7 6.8 0.0 4.0 4 0 0 4 4 3 0 Domain of unknown function (DUF3850) PepSY_2 PF13670.6 PIK55123.1 - 0.26 11.3 1.9 38 4.4 0.0 3.3 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain zf-H2C2_5 PF13909.6 PIK55123.1 - 2.4 8.0 90.0 0.04 13.7 1.0 11.6 11 0 0 11 11 11 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 PIK55123.1 - 5.3 7.6 48.4 3 8.4 0.3 9.8 2 2 4 7 7 6 0 C2HE / C2H2 / C2HC zinc-binding finger EF-hand_7 PF13499.6 PIK55124.1 - 4.7e-14 52.6 0.2 6.4e-09 36.1 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 PIK55124.1 - 1.6e-11 44.3 0.1 4.6e-05 23.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 PIK55124.1 - 1.6e-10 40.0 0.2 0.00075 19.2 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 PIK55124.1 - 3.1e-08 33.3 0.3 0.00026 20.8 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK55124.1 - 3.1e-08 32.6 0.7 0.00044 19.6 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_14 PF17959.1 PIK55124.1 - 0.0065 16.8 0.0 0.62 10.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 PIK55124.1 - 0.024 14.7 0.4 0.048 13.8 0.4 1.4 1 0 0 1 1 1 0 Ca2+ insensitive EF hand EF-hand_5 PF13202.6 PIK55124.1 - 0.039 13.5 0.0 0.039 13.5 0.0 2.4 3 0 0 3 3 3 0 EF hand DUF2666 PF10869.8 PIK55124.1 - 0.1 12.8 0.2 0.22 11.7 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) ECH_1 PF00378.20 PIK55125.1 - 5e-32 111.2 0.1 2e-30 105.9 0.0 2.4 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK55125.1 - 1.5e-22 80.5 0.1 9e-21 74.7 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 PIK55126.1 - 5.6e-22 78.2 0.0 6.1e-21 74.8 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK55126.1 - 2e-14 53.7 0.0 1.9e-13 50.5 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TPR_1 PF00515.28 PIK55127.1 - 2.5e-18 65.0 11.4 9.3e-06 25.3 0.5 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK55127.1 - 1.6e-15 55.9 10.6 5.1e-05 23.1 0.4 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55127.1 - 4.7e-11 42.0 12.7 0.00048 20.1 2.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55127.1 - 1.7e-10 41.0 2.4 8.9e-08 32.3 0.7 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK55127.1 - 1e-08 34.9 1.2 3e-06 27.2 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55127.1 - 1.7e-08 34.0 0.6 1.7e-08 34.0 0.6 3.0 3 0 0 3 3 3 1 TPR repeat TPR_7 PF13176.6 PIK55127.1 - 1.2e-07 31.3 1.7 0.0078 16.2 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55127.1 - 4.9e-05 23.9 0.3 0.0095 16.6 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 PIK55127.1 - 5.2e-05 23.2 9.6 0.043 13.9 2.0 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 PIK55127.1 - 0.00023 21.6 5.2 0.13 12.9 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55127.1 - 0.00027 21.5 0.2 2.7 9.1 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 PIK55127.1 - 0.00096 18.6 7.0 0.0091 15.4 3.5 2.0 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 PIK55127.1 - 0.0017 18.8 0.8 0.048 14.2 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 PIK55127.1 - 0.0072 16.2 2.4 1.8 8.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3450 PF11932.8 PIK55127.1 - 0.033 13.5 1.4 0.77 9.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SPO22 PF08631.10 PIK55127.1 - 0.068 12.6 6.1 2.2 7.7 0.4 3.0 2 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 PIK55127.1 - 0.14 12.2 11.2 0.36 10.9 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 PIK55127.1 - 8.9 7.6 12.7 19 6.6 0.0 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.28 PIK55128.1 - 3.2e-24 83.7 7.2 1.1e-07 31.3 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55128.1 - 5.9e-16 57.9 3.1 9.9e-10 37.9 0.2 3.5 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.17 PIK55128.1 - 6e-16 57.2 7.9 2.2e-05 24.2 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat STI1 PF17830.1 PIK55128.1 - 6.1e-16 58.1 5.5 9.3e-16 57.5 4.2 2.0 2 0 0 2 2 2 1 STI1 domain TPR_8 PF13181.6 PIK55128.1 - 2.9e-12 45.8 4.8 2.8e-05 24.0 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55128.1 - 1.6e-09 38.1 3.2 0.00043 20.7 0.2 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55128.1 - 6.3e-09 36.3 0.8 4.1e-05 24.1 0.1 2.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK55128.1 - 1.7e-08 34.2 4.4 0.068 13.6 0.2 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55128.1 - 2.2e-08 34.2 2.9 0.0052 17.5 0.1 3.7 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK55128.1 - 3.2e-08 33.6 1.0 0.0012 19.0 0.1 3.8 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55128.1 - 9.3e-06 25.8 3.3 0.1 12.9 1.6 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK55128.1 - 1.3e-05 25.5 4.2 0.0052 17.3 0.1 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK55128.1 - 0.0047 17.0 2.2 3.1 7.9 0.0 2.9 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 PIK55128.1 - 0.0095 15.9 0.6 14 6.0 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 PIK55128.1 - 0.012 16.1 1.0 0.48 10.9 0.2 2.3 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 PIK55128.1 - 0.09 13.0 5.3 0.21 11.8 3.7 2.1 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 PIK55128.1 - 0.1 12.5 0.9 13 5.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 PIK55128.1 - 0.45 10.2 3.8 1.1 9.0 0.2 2.5 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_21 PF09976.9 PIK55128.1 - 0.45 10.2 3.1 1.6 8.4 0.6 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Beach PF02138.18 PIK55129.1 - 1.9e-15 57.0 0.0 2.6e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 PIK55129.1 - 1.6e-07 31.9 5.1 0.00033 21.4 0.1 5.0 3 1 0 3 3 3 1 WD domain, G-beta repeat PH_BEACH PF14844.6 PIK55130.1 - 1e-18 67.3 0.0 2.9e-18 65.8 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Beach PF02138.18 PIK55130.1 - 6.8e-16 58.4 0.1 1.5e-15 57.3 0.1 1.6 1 0 0 1 1 1 1 Beige/BEACH domain GRAM PF02893.20 PIK55130.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 GRAM domain BBS1 PF14779.6 PIK55130.1 - 0.36 10.2 2.8 10 5.5 1.4 2.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 Laminin_G_3 PF13385.6 PIK55131.1 - 4.2e-07 30.2 0.0 0.0024 18.0 0.0 2.2 1 1 1 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Med29 PF11568.8 PIK55133.1 - 1.3e-34 119.4 4.6 1.6e-34 119.1 4.6 1.2 1 0 0 1 1 1 1 Mediator complex subunit 29 GrpE PF01025.19 PIK55133.1 - 0.023 14.3 0.7 0.028 14.1 0.7 1.2 1 0 0 1 1 1 0 GrpE NADH_dhqG_C PF09326.11 PIK55133.1 - 0.024 15.3 2.2 0.074 13.8 0.2 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal SH3BP5 PF05276.14 PIK55133.1 - 0.38 10.5 7.5 0.85 9.4 7.5 1.6 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Peptidase_M14 PF00246.24 PIK55134.1 - 2.3e-26 93.3 0.0 2.9e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase IRF-3 PF10401.9 PIK55134.1 - 0.1 12.4 0.2 0.24 11.2 0.1 1.6 2 0 0 2 2 2 0 Interferon-regulatory factor 3 3HBOH PF10605.9 PIK55134.1 - 0.11 10.7 0.0 0.16 10.2 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) CPSase_L_D2 PF02786.17 PIK55136.1 - 5.9e-80 267.7 0.1 9.2e-80 267.1 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 PIK55136.1 - 2e-61 207.2 0.1 3.8e-61 206.3 0.1 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 PIK55136.1 - 1.2e-41 141.6 0.0 2.5e-41 140.6 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 PIK55136.1 - 8.1e-35 119.2 0.0 3.2e-34 117.3 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 PIK55136.1 - 1e-27 97.3 0.0 2.5e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 PIK55136.1 - 9e-19 67.1 8.7 1.8e-18 66.1 7.1 2.4 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 PIK55136.1 - 2.4e-09 37.0 0.0 4.8e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 PIK55136.1 - 3.2e-07 30.0 6.2 0.0025 17.6 1.5 3.2 2 1 1 3 3 3 2 Biotin-lipoyl like ATP-grasp PF02222.22 PIK55136.1 - 3.3e-07 30.0 0.1 7.9e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 PIK55136.1 - 0.00015 21.1 0.6 0.21 10.7 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 PIK55136.1 - 0.00029 20.9 0.0 0.00062 19.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 PIK55136.1 - 0.00079 18.8 0.0 0.0067 15.7 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 PIK55136.1 - 0.0024 17.5 0.0 0.0098 15.5 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_3 PF13437.6 PIK55136.1 - 0.011 16.5 0.7 3 8.6 0.1 3.0 2 0 0 2 2 2 0 HlyD family secretion protein GCV_H PF01597.19 PIK55136.1 - 0.011 15.6 1.5 0.024 14.5 1.5 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein PTS_EIIA_1 PF00358.20 PIK55136.1 - 0.018 14.8 0.7 0.076 12.8 0.3 2.3 2 1 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 NQRA PF05896.11 PIK55136.1 - 0.026 13.9 2.6 0.03 13.8 1.5 1.6 2 0 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) RnfC_N PF13375.6 PIK55136.1 - 0.036 14.0 4.9 0.029 14.3 1.0 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain PYNP_C PF07831.13 PIK55136.1 - 0.055 13.1 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain ATP-grasp_4 PF13535.6 PIK55136.1 - 0.077 12.6 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain ATPgrasp_YheCD PF14398.6 PIK55136.1 - 0.12 11.6 0.0 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 YheC/D like ATP-grasp IQ PF00612.27 PIK55139.1 - 0.012 15.3 1.2 0.022 14.5 1.2 1.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif RhoGAP PF00620.27 PIK55141.1 - 9.6e-39 132.6 0.5 1.7e-38 131.8 0.5 1.3 1 0 0 1 1 1 1 RhoGAP domain RVT_1 PF00078.27 PIK55142.1 - 8.6e-12 45.0 0.0 1.1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.6 PIK55143.1 - 9.8e-25 85.8 21.4 2.4e-07 30.8 0.4 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK55143.1 - 1.6e-07 31.6 27.4 0.0015 19.2 0.6 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK55143.1 - 4.7e-05 23.6 8.9 0.0017 18.7 0.7 5.7 5 1 0 5 5 5 2 Zinc finger, C2H2 type zf-Sec23_Sec24 PF04810.15 PIK55143.1 - 0.00034 20.6 4.3 1.6 8.8 0.1 3.5 3 0 0 3 3 3 2 Sec23/Sec24 zinc finger Zf_RING PF16744.5 PIK55143.1 - 0.0023 18.0 9.1 0.61 10.2 0.5 3.1 2 1 1 3 3 3 2 KIAA1045 RING finger zf-met PF12874.7 PIK55143.1 - 0.011 16.1 21.1 0.027 14.9 0.6 4.4 4 1 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK55143.1 - 0.011 16.0 8.9 0.035 14.4 2.8 4.0 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding tRNA_Me_trans PF03054.16 PIK55143.1 - 0.063 12.1 2.3 0.076 11.8 2.3 1.1 1 0 0 1 1 1 0 tRNA methyl transferase GAGA PF09237.11 PIK55143.1 - 0.66 9.8 3.7 0.98 9.3 0.1 2.7 2 2 1 3 3 3 0 GAGA factor zf-BED PF02892.15 PIK55143.1 - 1 9.4 18.1 3 7.9 1.7 4.2 1 1 3 4 4 4 0 BED zinc finger DUF2197 PF09963.9 PIK55143.1 - 2 8.7 8.8 16 5.9 0.1 3.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-Di19 PF05605.12 PIK55143.1 - 3 8.2 19.4 0.68 10.3 2.6 3.2 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 PIK55144.1 - 2.7e-27 93.9 24.4 7.8e-09 35.6 0.7 4.3 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK55144.1 - 3.6e-09 36.7 31.6 0.0032 18.2 1.3 5.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK55144.1 - 2.7e-08 33.8 37.1 0.00062 20.1 1.5 5.3 5 1 0 5 5 5 3 Zinc finger, C2H2 type DUF3268 PF11672.8 PIK55144.1 - 0.00056 20.2 9.6 0.17 12.2 0.3 2.1 2 0 0 2 2 2 2 zinc-finger-containing domain zf-met PF12874.7 PIK55144.1 - 0.00078 19.7 22.9 0.033 14.6 1.7 4.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-Sec23_Sec24 PF04810.15 PIK55144.1 - 0.0018 18.3 13.2 1.8 8.7 0.3 4.4 3 1 1 4 4 4 2 Sec23/Sec24 zinc finger PyrI_C PF02748.15 PIK55144.1 - 0.0071 16.2 17.6 0.84 9.6 0.7 4.2 3 1 1 4 4 4 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain Elf1 PF05129.13 PIK55144.1 - 0.012 15.7 2.3 0.012 15.7 2.3 3.2 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 PIK55144.1 - 0.017 15.1 22.3 0.036 14.1 3.4 4.3 1 1 3 4 4 4 0 BED zinc finger zinc_ribbon_15 PF17032.5 PIK55144.1 - 0.019 15.7 14.0 0.37 11.6 6.1 2.2 1 1 1 2 2 2 0 zinc-ribbon family zf-CHCC PF10276.9 PIK55144.1 - 0.029 14.4 11.8 0.045 13.8 0.3 3.9 4 0 0 4 4 4 0 Zinc-finger domain zf-C2H2_6 PF13912.6 PIK55144.1 - 0.055 13.5 1.4 0.055 13.5 1.4 5.6 6 1 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK55144.1 - 0.057 13.7 25.3 0.16 12.3 3.2 4.8 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zf_RING PF16744.5 PIK55144.1 - 0.075 13.2 14.4 2 8.6 1.8 3.8 1 1 3 4 4 4 0 KIAA1045 RING finger GAGA PF09237.11 PIK55144.1 - 0.086 12.7 0.4 0.086 12.7 0.4 3.1 1 1 3 4 4 4 0 GAGA factor zf-C2H2_2 PF12756.7 PIK55144.1 - 0.1 13.0 19.5 2.5 8.5 10.7 3.8 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Rpr2 PF04032.16 PIK55144.1 - 0.48 10.8 9.2 0.44 10.9 4.6 2.6 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-piccolo PF05715.13 PIK55144.1 - 0.61 10.3 9.1 0.11 12.6 3.6 2.4 2 1 1 3 3 3 0 Piccolo Zn-finger Yippee-Mis18 PF03226.14 PIK55144.1 - 3.7 7.8 13.6 2.9 8.1 1.3 3.5 2 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2256 PF10013.9 PIK55144.1 - 9.4 6.5 13.5 0.65 10.2 0.5 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 PF13465.6 PIK55145.1 - 4.6e-24 83.7 17.7 4.7e-09 36.3 0.7 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK55145.1 - 1.9e-07 31.3 21.4 0.0052 17.5 1.6 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK55145.1 - 3.5e-06 27.2 26.7 0.002 18.5 2.1 4.4 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-BED PF02892.15 PIK55145.1 - 0.00036 20.5 15.8 0.0058 16.6 3.3 3.4 1 1 2 3 3 3 2 BED zinc finger Rpr2 PF04032.16 PIK55145.1 - 0.0011 19.2 6.3 0.016 15.4 1.6 2.6 1 1 1 3 3 3 2 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF3268 PF11672.8 PIK55145.1 - 0.0041 17.4 1.8 0.4 11.0 0.4 2.1 2 0 0 2 2 2 1 zinc-finger-containing domain zf-C2H2_2 PF12756.7 PIK55145.1 - 0.0046 17.3 10.4 0.069 13.5 10.6 2.7 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) Elf1 PF05129.13 PIK55145.1 - 0.0051 16.8 10.6 0.011 15.7 2.9 2.2 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like zf-piccolo PF05715.13 PIK55145.1 - 0.0092 16.1 0.9 0.0092 16.1 0.9 1.7 2 0 0 2 2 2 1 Piccolo Zn-finger zf-C2H2_jaz PF12171.8 PIK55145.1 - 0.012 15.9 16.0 0.085 13.2 1.1 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-CHCC PF10276.9 PIK55145.1 - 0.013 15.5 0.3 0.013 15.5 0.3 2.6 3 0 0 3 3 2 0 Zinc-finger domain PyrI_C PF02748.15 PIK55145.1 - 0.019 14.9 8.7 0.17 11.8 0.7 3.0 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2039 PF10217.9 PIK55145.1 - 0.02 15.2 7.5 0.037 14.4 7.5 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) zinc_ribbon_15 PF17032.5 PIK55145.1 - 0.028 15.1 5.0 3.7 8.4 4.8 2.1 1 1 1 2 2 2 0 zinc-ribbon family zf-Sec23_Sec24 PF04810.15 PIK55145.1 - 0.029 14.4 8.9 1.5 9.0 0.3 3.1 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger C1_1 PF00130.22 PIK55145.1 - 0.029 14.2 9.0 1.3 8.9 0.3 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.7 PIK55145.1 - 0.039 14.3 2.4 0.039 14.3 2.4 3.6 3 1 0 3 3 3 0 Zinc-finger of C2H2 type Zf_RING PF16744.5 PIK55145.1 - 0.042 13.9 6.7 0.69 10.1 0.2 3.0 1 1 1 3 3 3 0 KIAA1045 RING finger DUF2256 PF10013.9 PIK55145.1 - 0.044 13.9 7.1 0.41 10.8 0.5 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-CHY PF05495.12 PIK55145.1 - 0.092 13.2 13.1 0.093 13.2 7.1 2.1 1 1 1 2 2 2 0 CHY zinc finger zf-AN1 PF01428.16 PIK55145.1 - 0.28 11.4 14.2 5.2 7.3 2.0 3.3 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 PIK55145.1 - 0.28 11.9 6.4 2.7 8.7 1.9 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF2318 PF10080.9 PIK55145.1 - 0.35 11.0 4.9 1 9.5 1.7 2.4 1 1 0 2 2 2 0 Predicted membrane protein (DUF2318) Lar_restr_allev PF14354.6 PIK55145.1 - 0.47 10.9 4.5 3.6 8.1 4.5 2.0 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-trcl PF13451.6 PIK55145.1 - 0.63 10.0 10.4 3.3 7.7 0.1 3.0 2 1 0 2 2 2 0 Probable zinc-ribbon domain Cript PF10235.9 PIK55145.1 - 0.74 10.4 6.6 0.38 11.3 3.3 1.9 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT Zn-ribbon_8 PF09723.10 PIK55145.1 - 1.3 9.2 8.3 10 6.3 0.1 2.7 2 1 0 2 2 2 0 Zinc ribbon domain LIM PF00412.22 PIK55145.1 - 1.4 9.2 12.0 13 6.2 4.2 2.9 1 1 2 3 3 3 0 LIM domain FYDLN_acid PF09538.10 PIK55145.1 - 1.8 9.3 3.5 34 5.2 0.4 2.6 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) FYVE PF01363.21 PIK55145.1 - 3.7 7.7 13.7 12 6.1 4.7 2.3 1 1 1 2 2 2 0 FYVE zinc finger Zn_Tnp_IS1595 PF12760.7 PIK55145.1 - 4.7 7.3 12.2 15 5.7 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2HC_2 PF13913.6 PIK55145.1 - 9.1 6.3 14.8 2.3 8.2 0.8 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK55145.1 - 9.7 6.7 12.6 15 6.1 0.6 3.2 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Laminin_G_3 PF13385.6 PIK55146.1 - 1.1e-21 77.5 4.2 2.2e-06 27.9 0.0 5.2 4 1 0 4 4 4 4 Concanavalin A-like lectin/glucanases superfamily VWD PF00094.25 PIK55146.1 - 6.1e-09 36.3 11.2 0.0004 20.7 2.1 4.0 4 0 0 4 4 4 2 von Willebrand factor type D domain EGF_2 PF07974.13 PIK55146.1 - 0.00022 21.5 12.5 0.00022 21.5 12.5 10.0 8 1 1 9 9 9 3 EGF-like domain Laminin_EGF PF00053.24 PIK55146.1 - 0.0035 17.4 12.3 0.0035 17.4 12.3 7.0 5 2 2 7 7 7 3 Laminin EGF domain VWD PF00094.25 PIK55147.1 - 1e-23 84.4 3.2 2.5e-11 44.1 0.6 3.5 3 0 0 3 3 3 2 von Willebrand factor type D domain Laminin_G_3 PF13385.6 PIK55147.1 - 1.4e-11 44.8 4.7 0.0075 16.4 0.4 4.1 3 1 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 PIK55147.1 - 0.00013 22.3 25.3 0.00092 19.5 10.2 19.2 17 3 1 18 18 18 7 EGF-like domain EGF PF00008.27 PIK55147.1 - 0.0028 17.9 4.6 0.0028 17.9 4.6 15.1 15 1 0 15 15 15 6 EGF-like domain EGF_Tenascin PF18720.1 PIK55147.1 - 0.0036 17.3 11.0 0.0036 17.3 11.0 14.3 11 4 2 13 13 13 2 Tenascin EGF domain Imm45 PF15572.6 PIK55161.1 - 0.0086 16.4 0.0 38 4.7 0.0 3.7 3 0 0 3 3 3 2 Immunity protein 45 DUF5498 PF17602.2 PIK55161.1 - 0.023 15.2 1.0 16 6.1 0.0 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5498) p450 PF00067.22 PIK55163.1 - 4.7e-34 117.9 0.1 5e-34 117.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 EMP70 PF02990.16 PIK55164.1 - 3e-127 425.5 36.9 7.3e-88 295.5 31.7 2.3 2 1 1 3 3 3 2 Endomembrane protein 70 Exo_endo_phos PF03372.23 PIK55165.1 - 0.00057 19.5 0.0 0.00068 19.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK55165.1 - 0.0015 18.4 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ULD PF16534.5 PIK55166.1 - 2.8e-22 78.8 0.0 9.1e-22 77.2 0.1 1.9 2 1 0 2 2 2 1 Ubiquitin-like oligomerisation domain of SATB Homeodomain PF00046.29 PIK55166.1 - 2.2e-10 40.2 3.1 0.0002 21.2 0.5 2.9 2 0 0 2 2 2 2 Homeodomain CUTL PF16557.5 PIK55166.1 - 0.00057 20.0 0.0 0.0024 18.0 0.0 2.1 2 0 0 2 2 2 1 CUT1-like DNA-binding domain of SATB Misat_Tub_SegII PF10644.9 PIK55166.1 - 0.11 12.9 0.2 0.68 10.3 0.0 2.4 3 0 0 3 3 3 0 Misato Segment II tubulin-like domain UPF0179 PF03684.13 PIK55167.1 - 0.14 12.1 0.5 0.31 10.9 0.1 1.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0179) RRM_1 PF00076.22 PIK55168.1 - 0.00016 21.4 0.3 0.021 14.6 0.1 2.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad52_Rad22 PF04098.15 PIK55168.1 - 0.0029 17.6 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein IQ_SEC7_PH PF16453.5 PIK55168.1 - 0.041 13.9 0.5 0.088 12.8 0.5 1.6 1 0 0 1 1 1 0 PH domain DUF1652 PF07865.11 PIK55168.1 - 0.097 12.5 0.1 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) CRAL_TRIO_N PF03765.15 PIK55168.1 - 0.16 12.2 0.0 0.43 10.8 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain Mito_carr PF00153.27 PIK55169.1 - 1.4e-50 169.2 4.5 1.5e-21 76.1 0.1 3.2 2 1 0 3 3 3 3 Mitochondrial carrier protein zf-H2C2_2 PF13465.6 PIK55170.1 - 7e-71 231.7 91.1 1.8e-09 37.6 0.7 10.2 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55170.1 - 1.1e-45 151.6 84.4 3.2e-06 27.3 1.3 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55170.1 - 9.5e-33 110.0 76.7 0.00043 20.9 1.0 10.1 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK55170.1 - 4.9e-16 58.6 69.0 0.0041 17.4 0.2 10.6 10 1 0 10 10 9 8 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK55170.1 - 2.6e-14 52.9 51.2 0.09 12.7 0.4 9.4 8 1 1 9 9 9 8 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK55170.1 - 4.3e-14 52.0 40.0 0.018 14.8 0.7 9.2 9 0 0 9 9 9 6 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 PIK55170.1 - 4.6e-11 42.4 67.0 0.06 13.4 0.7 9.8 9 0 0 9 9 9 6 C2H2-type zinc finger C1_4 PF07975.12 PIK55170.1 - 5.8e-10 39.3 41.2 0.0086 16.3 1.3 7.1 1 1 6 8 8 8 5 TFIIH C1-like domain zf-met PF12874.7 PIK55170.1 - 2e-09 37.5 77.4 0.027 14.8 1.0 10.2 10 1 0 10 10 8 7 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 PIK55170.1 - 1.6e-08 34.2 40.4 0.76 9.7 0.3 9.8 10 0 0 10 10 9 4 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK55170.1 - 2e-07 31.3 55.6 0.64 10.5 1.0 9.3 1 1 8 9 9 9 6 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK55170.1 - 2.5e-06 27.4 58.6 0.83 9.7 0.9 9.3 1 1 8 9 9 9 6 BED zinc finger zf-AN1 PF01428.16 PIK55170.1 - 3.2e-06 27.2 54.2 2.8 8.2 0.2 9.3 8 1 1 9 9 9 3 AN1-like Zinc finger Glyco_hydro_2_C PF02836.17 PIK55170.1 - 0.0016 17.6 17.9 0.046 12.8 2.0 3.4 1 1 2 3 3 3 3 Glycosyl hydrolases family 2, TIM barrel domain zf-Di19 PF05605.12 PIK55170.1 - 0.0068 16.7 48.7 0.25 11.7 3.2 6.4 3 3 0 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.8 PIK55170.1 - 0.019 15.3 35.1 0.26 11.6 1.9 5.0 4 1 2 6 6 6 0 zinc-finger-containing domain zf_UBZ PF18439.1 PIK55170.1 - 0.024 14.2 36.2 9.4 5.9 0.3 9.1 9 0 0 9 9 9 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 PIK55170.1 - 0.15 12.8 44.2 0.4 11.5 2.4 5.6 1 1 4 7 7 7 0 zinc-ribbon family zf-Dof PF02701.15 PIK55170.1 - 0.43 10.8 44.0 1.5 9.0 0.4 7.1 2 2 5 7 7 7 0 Dof domain, zinc finger zinc_ribbon_9 PF14369.6 PIK55170.1 - 0.56 10.5 21.8 53 4.2 0.0 8.0 9 0 0 9 9 9 0 zinc-ribbon EKAL PF17986.1 PIK55170.1 - 1.4 9.0 23.5 39 4.4 0.1 7.4 4 4 3 8 8 8 0 EMP3-KAHRP-like N-terminal domain zf-CHCC PF10276.9 PIK55170.1 - 3.4 7.8 60.8 3.5 7.8 1.5 9.3 9 0 0 9 9 9 0 Zinc-finger domain Yippee-Mis18 PF03226.14 PIK55170.1 - 4.5 7.5 27.3 48 4.2 9.4 5.5 2 2 2 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-H2C2_2 PF13465.6 PIK55171.1 - 2.7e-182 583.9 223.3 1.1e-09 38.2 2.3 23.0 23 0 0 23 23 23 23 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55171.1 - 7.6e-109 350.5 202.5 1e-05 25.7 2.2 23.1 23 0 0 23 23 23 23 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55171.1 - 1.2e-80 259.1 185.0 0.0013 19.4 1.8 23.1 23 0 0 23 23 23 23 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK55171.1 - 2.4e-35 120.1 166.9 0.0054 17.0 1.1 23.1 23 0 0 23 23 23 18 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK55171.1 - 6.1e-27 92.9 98.2 0.29 11.1 0.2 23.5 23 0 0 23 23 23 14 zinc-finger of a C2HC-type PyrI_C PF02748.15 PIK55171.1 - 1.4e-23 82.6 168.8 0.2 11.6 0.4 23.1 19 4 4 23 23 23 18 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK55171.1 - 1.4e-22 79.1 88.7 0.014 15.1 0.0 21.9 23 0 0 23 23 23 9 zinc-finger C2H2-type C1_4 PF07975.12 PIK55171.1 - 1.1e-21 76.8 119.8 0.0013 18.9 1.7 16.0 5 3 8 16 16 16 11 TFIIH C1-like domain zf-met PF12874.7 PIK55171.1 - 3.5e-08 33.6 179.8 0.16 12.4 3.0 22.3 23 0 0 23 23 23 12 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK55171.1 - 5.2e-08 32.7 188.0 0.23 11.5 0.9 24.2 23 2 0 23 23 23 14 C2H2-type zinc finger zf-AN1 PF01428.16 PIK55171.1 - 2e-07 31.0 137.3 9.1 6.5 0.3 23.0 21 2 2 23 23 23 0 AN1-like Zinc finger zf-C2HE PF16278.5 PIK55171.1 - 8.3e-06 26.2 151.3 0.14 12.6 0.6 22.4 3 3 18 21 21 21 5 C2HE / C2H2 / C2HC zinc-binding finger Glyco_hydro_2_C PF02836.17 PIK55171.1 - 0.00013 21.2 64.2 0.79 8.8 1.9 9.2 1 1 8 9 9 9 6 Glycosyl hydrolases family 2, TIM barrel domain DUF3268 PF11672.8 PIK55171.1 - 0.00033 21.0 115.6 0.57 10.5 2.0 12.0 6 1 5 14 14 14 8 zinc-finger-containing domain zf-BED PF02892.15 PIK55171.1 - 0.00079 19.4 162.1 0.7 10.0 1.0 22.9 1 1 22 23 23 23 8 BED zinc finger zinc_ribbon_15 PF17032.5 PIK55171.1 - 0.0049 17.6 123.5 0.89 10.3 4.2 12.0 2 2 14 18 18 18 9 zinc-ribbon family zf-H2C2_5 PF13909.6 PIK55171.1 - 0.0099 15.6 11.8 0.02 14.6 3.5 27.8 24 10 0 24 24 19 6 C2H2-type zinc-finger domain Lipocalin_5 PF13924.6 PIK55171.1 - 0.02 14.7 25.4 5.4 6.8 0.8 8.0 3 3 3 8 8 8 0 Lipocalin-like domain GAGA PF09237.11 PIK55171.1 - 0.046 13.5 48.8 0.096 12.5 0.1 11.8 4 3 11 16 16 16 0 GAGA factor EKAL PF17986.1 PIK55171.1 - 0.079 13.0 83.5 0.97 9.5 0.1 17.9 7 6 13 20 20 20 0 EMP3-KAHRP-like N-terminal domain BolA PF01722.18 PIK55171.1 - 2 8.8 31.3 21 5.5 0.4 8.8 5 3 0 5 5 5 0 BolA-like protein zf-H2C2_2 PF13465.6 PIK55172.1 - 1.9e-68 224.1 63.2 1.3e-10 41.2 2.0 8.2 8 0 0 8 8 8 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55172.1 - 2.3e-40 134.8 71.5 7.9e-07 29.2 2.6 9.6 9 1 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55172.1 - 7.4e-27 91.7 59.2 0.00015 22.3 2.0 9.2 9 0 0 9 9 9 7 C2H2-type zinc finger PyrI_C PF02748.15 PIK55172.1 - 1.9e-14 53.3 43.0 0.019 14.9 0.4 8.1 7 1 1 8 8 8 7 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 PIK55172.1 - 1.1e-13 51.5 44.8 0.03 14.8 0.2 8.1 1 1 7 8 8 8 6 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 PIK55172.1 - 1.4e-13 50.3 29.2 0.012 15.4 0.3 8.3 9 0 0 9 9 8 6 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 PIK55172.1 - 1.4e-10 40.8 29.0 0.13 12.2 0.2 8.8 9 0 0 9 9 9 4 zinc-finger of a C2HC-type zf-AN1 PF01428.16 PIK55172.1 - 2.7e-09 37.0 35.5 1.9 8.7 0.2 8.2 8 0 0 8 8 8 5 AN1-like Zinc finger zf-C2H2_jaz PF12171.8 PIK55172.1 - 4.4e-09 36.4 59.9 0.0078 16.5 1.4 9.6 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding C1_1 PF00130.22 PIK55172.1 - 1.1e-07 31.6 26.3 0.35 10.8 0.2 6.7 1 1 6 7 7 7 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-BED PF02892.15 PIK55172.1 - 6.6e-07 29.3 47.6 1.1 9.4 0.5 8.2 1 1 7 8 8 8 5 BED zinc finger zf-CHCC PF10276.9 PIK55172.1 - 6.6e-06 26.1 49.9 1.2 9.2 0.3 8.1 8 0 0 8 8 8 6 Zinc-finger domain zf-met PF12874.7 PIK55172.1 - 1.7e-05 25.0 60.2 0.1 13.0 0.6 9.1 9 0 0 9 9 8 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK55172.1 - 9.1e-05 22.4 59.8 0.41 10.7 0.8 8.9 9 0 0 9 9 9 4 C2H2-type zinc finger DUF3506 PF12014.8 PIK55172.1 - 0.00026 21.0 0.6 26 4.8 0.0 5.2 2 2 3 5 5 5 0 Domain of unknown function (DUF3506) DUF3268 PF11672.8 PIK55172.1 - 0.00028 21.2 30.6 0.0031 17.8 1.0 4.2 3 1 0 4 4 4 2 zinc-finger-containing domain C1_4 PF07975.12 PIK55172.1 - 0.00059 20.0 39.1 0.64 10.3 4.4 5.9 1 1 5 7 7 7 3 TFIIH C1-like domain zinc_ribbon_9 PF14369.6 PIK55172.1 - 0.00093 19.4 18.2 10 6.5 0.0 7.7 8 0 0 8 8 8 0 zinc-ribbon zinc_ribbon_15 PF17032.5 PIK55172.1 - 0.0011 19.6 31.3 0.72 10.6 1.0 4.2 3 1 1 4 4 4 3 zinc-ribbon family zf-H2C2_5 PF13909.6 PIK55172.1 - 0.0027 17.4 12.1 0.0086 15.8 4.0 10.8 9 3 0 9 9 8 3 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 PIK55172.1 - 0.0078 16.5 41.5 0.92 9.9 0.3 7.5 1 1 6 7 7 7 3 C2H2 type zinc-finger (2 copies) BolA PF01722.18 PIK55172.1 - 0.098 12.9 5.1 5.9 7.2 0.2 3.6 3 1 0 3 3 3 0 BolA-like protein Amidohydro_1 PF01979.20 PIK55172.1 - 0.11 11.7 1.0 1 8.6 0.5 2.1 1 1 1 2 2 2 0 Amidohydrolase family zinc-ribbons_6 PF07191.12 PIK55172.1 - 0.14 12.1 40.0 22 5.1 4.2 7.4 1 1 6 8 8 8 0 zinc-ribbons YyzF PF14116.6 PIK55172.1 - 0.18 11.9 38.1 0.69 10.0 0.5 7.9 5 1 3 8 8 8 0 YyzF-like protein Glyco_hydro_2_C PF02836.17 PIK55172.1 - 0.23 10.5 9.6 0.2 10.8 0.4 2.7 1 1 2 3 3 3 0 Glycosyl hydrolases family 2, TIM barrel domain zf-Di19 PF05605.12 PIK55172.1 - 0.27 11.6 43.9 1.5 9.2 4.5 6.5 2 2 4 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 PIK55172.1 - 0.4 10.3 35.7 5.9 6.6 0.3 7.8 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger FYDLN_acid PF09538.10 PIK55172.1 - 0.59 10.8 27.8 20 5.9 0.1 7.3 1 1 7 8 8 8 0 Protein of unknown function (FYDLN_acid) DUF3280 PF11684.8 PIK55172.1 - 0.85 10.0 18.5 12 6.3 0.2 6.3 1 1 7 8 8 8 0 Protein of unknown function (DUF2380) EKAL PF17986.1 PIK55172.1 - 0.89 9.6 23.6 11 6.2 0.3 6.6 3 2 3 6 6 6 0 EMP3-KAHRP-like N-terminal domain Zf_RING PF16744.5 PIK55172.1 - 1.4 9.1 32.3 23 5.2 2.0 7.3 1 1 6 7 7 7 0 KIAA1045 RING finger Evr1_Alr PF04777.13 PIK55172.1 - 4.1 7.9 38.7 5.4 7.6 0.2 7.4 1 1 6 7 7 7 0 Erv1 / Alr family Zn_Tnp_IS1595 PF12760.7 PIK55172.1 - 5.6 7.0 41.6 4.4 7.3 4.2 6.3 4 1 3 7 7 7 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 PIK55173.1 - 1.6e-48 161.0 48.0 1.1e-09 38.2 1.1 6.8 7 0 0 7 7 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55173.1 - 3.1e-26 90.3 45.5 4.1e-07 30.1 1.6 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55173.1 - 4.3e-20 70.7 39.9 0.00017 22.1 1.2 6.3 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK55173.1 - 1.9e-09 37.1 16.9 0.0064 16.2 0.2 5.2 5 0 0 5 5 5 4 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 PIK55173.1 - 4.8e-09 35.9 15.8 0.43 10.6 0.1 5.7 6 0 0 6 6 5 5 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK55173.1 - 6.4e-09 36.1 26.6 0.0088 16.5 0.5 5.3 1 1 4 5 5 5 3 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.15 PIK55173.1 - 1e-08 34.9 25.3 0.046 13.6 1.6 5.3 5 0 0 5 5 5 4 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK55173.1 - 1.9e-08 34.3 34.9 0.019 15.2 0.4 6.0 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 PIK55173.1 - 6.8e-08 32.1 12.8 3e-05 23.7 2.2 7.6 7 1 0 7 7 7 3 C2H2-type zinc-finger domain zf-BED PF02892.15 PIK55173.1 - 1.5e-05 24.9 28.9 0.059 13.4 1.9 5.5 1 1 3 4 4 4 2 BED zinc finger zf-Di19 PF05605.12 PIK55173.1 - 7.1e-05 23.0 21.5 0.094 13.0 4.5 4.4 1 1 2 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding EKAL PF17986.1 PIK55173.1 - 0.00095 19.2 10.0 4.3 7.4 0.1 5.0 3 2 2 5 5 5 1 EMP3-KAHRP-like N-terminal domain C1_1 PF00130.22 PIK55173.1 - 0.0025 17.7 16.9 1.2 9.1 1.7 4.7 1 1 3 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_9 PF14369.6 PIK55173.1 - 0.0034 17.6 8.9 17 5.7 0.1 5.4 5 0 0 5 5 5 0 zinc-ribbon zf-C2H2_6 PF13912.6 PIK55173.1 - 0.004 17.1 31.8 0.55 10.3 1.0 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger C1_4 PF07975.12 PIK55173.1 - 0.0054 16.9 23.0 0.11 12.8 3.8 4.3 1 1 4 5 5 5 3 TFIIH C1-like domain zf-C2H2_3rep PF18868.1 PIK55173.1 - 0.0066 17.1 17.9 1.2 9.8 1.1 4.6 1 1 4 5 5 5 2 Zinc finger C2H2-type, 3 repeats zf-AN1 PF01428.16 PIK55173.1 - 0.023 14.9 29.2 4.5 7.5 0.2 5.6 3 2 2 5 5 5 0 AN1-like Zinc finger BolA PF01722.18 PIK55173.1 - 0.094 13.0 6.3 4.7 7.6 0.6 3.4 2 1 0 2 2 2 0 BolA-like protein Zf_RING PF16744.5 PIK55173.1 - 0.18 12.0 17.7 16 5.7 1.9 5.2 1 1 4 5 5 5 0 KIAA1045 RING finger YyzF PF14116.6 PIK55173.1 - 0.21 11.7 18.7 7.8 6.6 0.2 5.2 5 0 0 5 5 5 0 YyzF-like protein zf_UBZ PF18439.1 PIK55173.1 - 0.35 10.5 15.7 3.1 7.5 0.2 5.2 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 PIK55173.1 - 0.37 11.2 35.4 0.41 11.1 1.8 5.8 5 1 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK55173.1 - 0.57 10.5 32.0 1.1 9.7 0.7 5.8 2 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) DUF3280 PF11684.8 PIK55173.1 - 0.57 10.6 9.2 36 4.8 0.2 4.3 1 1 4 5 5 5 0 Protein of unknown function (DUF2380) zinc_ribbon_15 PF17032.5 PIK55173.1 - 0.6 10.9 24.1 1 10.2 2.8 3.7 1 1 1 3 3 3 0 zinc-ribbon family zf-CHCC PF10276.9 PIK55173.1 - 0.64 10.1 33.0 1.9 8.6 1.2 4.7 5 0 0 5 5 4 0 Zinc-finger domain DUF3268 PF11672.8 PIK55173.1 - 1 9.7 20.2 1.8 8.9 2.9 3.2 1 1 2 4 4 4 0 zinc-finger-containing domain zf-Dof PF02701.15 PIK55173.1 - 1.1 9.4 17.3 10 6.3 2.0 4.5 1 1 2 3 3 3 0 Dof domain, zinc finger GAGA PF09237.11 PIK55173.1 - 1.3 8.9 8.1 12 5.7 0.1 3.8 1 1 4 5 5 5 0 GAGA factor zinc-ribbons_6 PF07191.12 PIK55173.1 - 1.5 8.8 23.8 26 4.9 0.4 4.9 1 1 3 4 4 4 0 zinc-ribbons CpXC PF14353.6 PIK55173.1 - 3.3 7.8 19.4 15 5.7 0.3 5.2 3 2 2 5 5 5 0 CpXC protein Yippee-Mis18 PF03226.14 PIK55173.1 - 3.7 7.8 14.2 13 6.1 5.0 4.0 1 1 2 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-H2C2_2 PF13465.6 PIK55174.1 - 6.4e-91 295.1 84.7 3.4e-10 39.9 2.0 12.0 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55174.1 - 1.9e-51 169.8 91.9 1.1e-06 28.7 1.7 11.7 12 0 0 12 12 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55174.1 - 4.1e-42 139.2 81.0 0.00021 21.9 0.8 11.8 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK55174.1 - 4.5e-17 61.5 30.9 0.00063 19.4 0.2 10.8 11 0 0 11 11 11 5 zinc-finger C2H2-type PyrI_C PF02748.15 PIK55174.1 - 1.4e-16 60.1 59.9 0.13 12.2 0.8 10.8 10 1 1 11 11 11 10 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK55174.1 - 5.6e-16 58.4 66.4 0.0098 16.2 0.2 11.2 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 PIK55174.1 - 6.6e-16 57.8 42.5 0.0018 18.1 0.1 11.4 11 0 0 11 11 11 6 zinc-finger of a C2HC-type C1_4 PF07975.12 PIK55174.1 - 3.1e-10 40.1 48.4 0.032 14.5 2.6 8.1 2 2 8 10 10 10 6 TFIIH C1-like domain zf-AN1 PF01428.16 PIK55174.1 - 5.3e-09 36.1 49.5 4 7.7 0.2 10.6 11 0 0 11 11 10 3 AN1-like Zinc finger zf-C2HE PF16278.5 PIK55174.1 - 6.7e-08 32.9 59.8 0.21 12.0 0.7 10.7 1 1 10 11 11 11 3 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK55174.1 - 6e-07 29.4 64.6 0.8 9.8 0.6 11.0 3 2 7 10 10 10 4 BED zinc finger zf-C2H2_6 PF13912.6 PIK55174.1 - 1.6e-06 28.0 73.1 0.015 15.3 1.7 11.5 11 0 0 11 11 11 4 C2H2-type zinc finger DUF3268 PF11672.8 PIK55174.1 - 0.0001 22.6 48.0 0.12 12.7 3.5 5.8 1 1 6 8 8 8 7 zinc-finger-containing domain DUF1294 PF06961.13 PIK55174.1 - 0.00095 19.4 1.9 3.8 7.8 0.0 4.2 5 0 0 5 5 3 1 Protein of unknown function (DUF1294) zinc_ribbon_15 PF17032.5 PIK55174.1 - 0.0012 19.5 48.0 0.47 11.2 3.8 5.8 2 2 4 7 7 7 3 zinc-ribbon family zinc_ribbon_9 PF14369.6 PIK55174.1 - 0.0018 18.5 26.2 9.8 6.5 0.1 9.4 8 2 2 10 10 10 0 zinc-ribbon EKAL PF17986.1 PIK55174.1 - 0.0019 18.2 29.0 14 5.9 0.0 9.1 4 2 6 10 10 10 0 EMP3-KAHRP-like N-terminal domain Baculo_IE-1 PF05290.11 PIK55174.1 - 0.003 17.5 41.4 4.7 7.2 0.6 9.3 1 1 8 10 10 10 1 Baculovirus immediate-early protein (IE-0) zf-H2C2_5 PF13909.6 PIK55174.1 - 0.0031 17.2 107.7 0.0043 16.8 2.4 13.5 12 4 0 12 12 12 7 C2H2-type zinc-finger domain zf-CHCC PF10276.9 PIK55174.1 - 0.0065 16.5 71.1 1.4 9.0 0.7 10.3 10 0 0 10 10 10 4 Zinc-finger domain zf-met PF12874.7 PIK55174.1 - 0.014 15.8 71.3 1.1 9.7 0.4 10.8 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Yippee-Mis18 PF03226.14 PIK55174.1 - 0.016 15.4 34.8 6 7.1 4.4 8.7 1 1 5 6 6 6 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3850 PF12961.7 PIK55174.1 - 0.021 14.9 0.8 3.2 7.8 0.0 4.1 3 2 0 3 3 3 0 Domain of unknown function (DUF3850) GAGA PF09237.11 PIK55174.1 - 0.04 13.7 20.9 1.6 8.6 0.2 6.7 3 2 5 8 8 8 0 GAGA factor RIG-I_C-RD PF11648.8 PIK55174.1 - 0.046 14.0 38.7 12 6.2 0.1 9.4 7 2 1 9 9 9 0 C-terminal domain of RIG-I Glyco_hydro_2_C PF02836.17 PIK55174.1 - 0.059 12.5 21.0 0.17 11.0 1.4 3.9 1 1 4 5 5 5 0 Glycosyl hydrolases family 2, TIM barrel domain PHF5 PF03660.14 PIK55174.1 - 0.15 12.3 28.3 0.85 9.9 1.3 4.9 1 1 3 5 5 5 0 PHF5-like protein BolA PF01722.18 PIK55174.1 - 0.48 10.7 12.2 8.6 6.7 0.7 4.8 2 2 1 4 4 4 0 BolA-like protein zf-Di19 PF05605.12 PIK55174.1 - 0.65 10.3 55.3 2.2 8.6 3.6 8.6 2 2 6 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding Zf_RING PF16744.5 PIK55174.1 - 1.1 9.4 44.8 34 4.6 0.3 9.9 1 1 9 10 10 10 0 KIAA1045 RING finger zf-C2H2_2 PF12756.7 PIK55174.1 - 1.5 9.2 59.3 3.5 8.0 0.9 9.8 1 1 9 10 10 10 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 PIK55174.1 - 1.6 8.9 34.9 15 5.7 0.1 9.8 11 0 0 11 11 11 0 XPA protein N-terminal CpXC PF14353.6 PIK55174.1 - 2.3 8.3 44.3 18 5.4 0.4 9.3 5 2 4 9 9 9 0 CpXC protein CLCA PF08434.11 PIK55175.1 - 1.4e-26 93.5 0.0 1.6e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Glycos_transf_2 PF00535.26 PIK55176.1 - 9.9e-25 87.3 0.0 1.7e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK55176.1 - 2.3e-17 63.4 1.2 3.6e-17 62.8 1.2 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 PIK55176.1 - 1.9e-06 27.4 0.0 4.1e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 PIK55176.1 - 9.8e-06 25.2 0.0 1.7e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 DUF4570 PF15134.6 PIK55177.1 - 4.2e-05 23.5 1.9 0.00016 21.6 1.9 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) XhlA PF10779.9 PIK55178.1 - 0.13 12.5 6.9 0.44 10.8 0.2 2.7 3 0 0 3 3 3 0 Haemolysin XhlA Tropomyosin_1 PF12718.7 PIK55178.1 - 2.6 8.2 10.0 15 5.8 6.9 2.8 2 1 0 2 2 2 0 Tropomyosin like Matrilin_ccoil PF10393.9 PIK55178.1 - 3.2 7.7 8.8 4.8 7.1 0.4 3.7 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Gal4_dimer PF03902.13 PIK55178.1 - 3.8 7.8 6.5 29 4.9 0.2 3.1 2 1 0 2 2 2 0 Gal4-like dimerisation domain DUF1759 PF03564.15 PIK55179.1 - 1.2e-07 31.8 0.1 2e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Tis11B_N PF04553.12 PIK55179.1 - 0.15 12.6 2.4 0.3 11.7 0.1 2.4 3 0 0 3 3 3 0 Tis11B like protein, N terminus DUF753 PF05444.12 PIK55179.1 - 4.1 7.4 7.9 0.99 9.4 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF753) Peptidase_A17 PF05380.13 PIK55180.1 - 1e-13 51.6 0.7 5.2e-13 49.3 0.0 2.3 2 0 0 2 2 2 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK55180.1 - 1.3e-05 24.9 0.0 2.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2353 PF09789.9 PIK55180.1 - 0.068 12.5 1.0 0.21 10.9 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF4201 PF13870.6 PIK55181.1 - 0.0037 17.0 15.8 0.0037 17.0 15.8 5.9 2 2 3 5 5 5 1 Domain of unknown function (DUF4201) GIT1_C PF12205.8 PIK55181.1 - 0.039 14.0 0.1 0.039 14.0 0.1 3.8 2 1 1 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term Filament PF00038.21 PIK55181.1 - 0.4 10.2 61.5 2 7.9 13.3 4.9 2 1 2 4 4 4 0 Intermediate filament protein Golgin_A5 PF09787.9 PIK55181.1 - 1.5 8.3 69.7 0.051 13.0 31.4 3.8 2 1 2 4 4 4 0 Golgin subfamily A member 5 Leu_zip PF15294.6 PIK55181.1 - 3.5 7.1 62.6 3.2 7.2 20.9 3.4 1 1 2 3 3 3 0 Leucine zipper BRE1 PF08647.11 PIK55182.1 - 3.3e-05 23.9 28.8 0.00019 21.5 2.1 21.4 7 6 12 22 22 22 7 BRE1 E3 ubiquitin ligase TPR_8 PF13181.6 PIK55182.1 - 6.4 7.3 5.5 15 6.1 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Chi-conotoxin PF16981.5 PIK55183.1 - 0.36 11.1 0.1 0.36 11.1 0.1 1.7 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily TPR_14 PF13428.6 PIK55184.1 - 1.1e-08 35.1 0.0 1.7 9.7 0.0 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat HAT PF02184.16 PIK55184.1 - 0.0011 18.9 0.3 0.3 11.1 0.0 3.9 4 0 0 4 4 4 1 HAT (Half-A-TPR) repeat Mad3_BUB1_I PF08311.12 PIK55184.1 - 0.0018 18.3 5.7 0.46 10.5 0.3 3.9 3 1 0 3 3 3 2 Mad3/BUB1 homology region 1 LRIF1 PF15741.5 PIK55184.1 - 0.021 13.4 0.2 0.021 13.4 0.2 1.7 2 0 0 2 2 2 0 Ligand-dependent nuclear receptor-interacting factor 1 TPR_15 PF13429.6 PIK55184.1 - 0.045 13.0 0.3 7.6 5.6 0.0 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55184.1 - 0.06 13.9 0.0 2.4 8.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat CLTH PF10607.9 PIK55185.1 - 0.00096 19.1 0.1 0.0013 18.7 0.1 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain WD40 PF00400.32 PIK55186.1 - 3.3e-10 40.4 0.1 0.00011 22.9 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55186.1 - 0.0014 18.9 0.1 0.0067 16.7 0.1 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK55187.1 - 4.5e-29 100.1 10.9 3.7e-05 24.4 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55187.1 - 3.7e-06 27.2 0.1 5 7.5 0.0 5.1 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK55187.1 - 0.00016 20.7 0.0 1 8.3 0.0 3.9 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein FANCI_S2 PF14676.6 PIK55188.1 - 0.035 14.4 4.1 0.052 13.9 1.8 2.5 2 0 0 2 2 2 0 FANCI solenoid 2 MAPKK1_Int PF08923.10 PIK55189.1 - 1.1e-08 34.9 0.2 4.9e-08 32.8 0.0 2.0 2 1 0 2 2 2 1 Mitogen-activated protein kinase kinase 1 interacting MTA_R1 PF17226.2 PIK55190.1 - 1.2e-25 89.5 1.4 3.3e-25 88.0 0.1 2.5 2 0 0 2 2 2 1 MTA R1 domain BAH PF01426.18 PIK55190.1 - 4.9e-21 74.8 0.0 1.4e-19 70.1 0.2 2.4 2 1 0 2 2 2 1 BAH domain ELM2 PF01448.24 PIK55190.1 - 2.3e-13 50.6 1.1 1.3e-12 48.3 0.1 2.7 3 0 0 3 3 3 1 ELM2 domain GATA PF00320.27 PIK55190.1 - 7.9e-07 28.6 11.0 2e-06 27.3 11.0 1.7 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.31 PIK55190.1 - 1.6e-06 28.2 0.2 5.3e-06 26.5 0.2 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 PIK55190.1 - 0.0051 16.7 0.2 0.021 14.7 0.2 2.0 1 0 0 1 1 1 1 Myb DNA-binding like PRIMA1 PF16101.5 PIK55190.1 - 0.13 12.3 8.5 0.35 10.9 8.5 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SNF PF00209.18 PIK55191.1 - 5.7e-37 127.6 1.5 7.3e-37 127.2 1.5 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 PIK55192.1 - 5.9e-90 302.4 16.1 7.6e-90 302.1 16.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family zf-UBR PF02207.20 PIK55192.1 - 0.0097 16.1 1.1 0.018 15.2 1.1 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) UBX PF00789.20 PIK55193.1 - 1.7e-23 82.6 0.0 3.9e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 PIK55193.1 - 0.00039 20.2 0.0 0.00082 19.2 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain QVR PF17064.5 PIK55193.1 - 0.064 13.5 0.4 0.21 11.9 0.4 1.8 1 0 0 1 1 1 0 Sleepless protein SOBP PF15279.6 PIK55193.1 - 2.6 8.6 8.5 3.6 8.1 8.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein FIBP PF05427.11 PIK55194.1 - 1.6e-137 458.6 6.2 2.2e-137 458.2 6.2 1.0 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) INT_SG_DDX_CT_C PF15300.6 PIK55194.1 - 0.061 13.1 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus DUF5105 PF17118.5 PIK55194.1 - 0.072 12.9 0.5 0.15 11.9 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5105) SPRY PF00622.28 PIK55195.1 - 9.6e-23 80.6 1.3 1.2e-07 31.8 0.1 4.8 4 1 0 4 4 4 3 SPRY domain TIR_2 PF13676.6 PIK55195.1 - 0.00036 21.1 0.0 0.00088 19.9 0.0 1.7 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 PIK55195.1 - 0.053 13.8 0.1 0.21 11.9 0.0 2.1 2 1 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) p450 PF00067.22 PIK55196.1 - 7.8e-21 74.4 0.0 8.8e-21 74.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK55197.1 - 3e-52 177.9 1.6 4.8e-52 177.2 0.0 1.8 2 0 0 2 2 2 1 Cytochrome P450 DUF448 PF04296.13 PIK55197.1 - 0.19 11.6 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF448) p450 PF00067.22 PIK55198.1 - 3.5e-71 240.3 0.0 3.9e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.21 PIK55199.1 - 9e-28 97.3 17.8 1.2e-27 96.9 17.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK55199.1 - 0.00031 20.2 17.0 0.0061 16.0 17.0 2.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0715 PF17094.5 PIK55199.1 - 0.01 16.4 0.5 0.01 16.4 0.5 3.2 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0715) DUF5400 PF17379.2 PIK55199.1 - 0.84 10.1 12.9 2.4 8.7 2.0 3.6 2 2 1 3 3 3 0 Family of unknown function (DUF5400) CCCAP PF15964.5 PIK55200.1 - 8.6e-114 381.3 81.7 1.1e-113 381.0 81.7 1.1 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family RhoGEF PF00621.20 PIK55201.1 - 1.6e-08 35.0 0.7 3.1e-08 34.1 0.7 1.5 1 0 0 1 1 1 1 RhoGEF domain Apt1 PF10351.9 PIK55202.1 - 0.0066 15.4 19.0 0.008 15.1 19.0 1.3 1 0 0 1 1 1 1 Golgi-body localisation protein domain Macoilin PF09726.9 PIK55202.1 - 0.062 11.9 18.3 0.073 11.6 18.3 1.2 1 0 0 1 1 1 0 Macoilin family PRP38_assoc PF12871.7 PIK55202.1 - 2.7 8.6 76.6 4.9e+02 1.4 76.7 2.8 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term CDC45 PF02724.14 PIK55202.1 - 3.5 5.8 28.4 1.4 7.1 26.1 1.6 2 0 0 2 2 2 0 CDC45-like protein NRDE-2 PF08424.10 PIK55203.1 - 1.5e-50 172.2 0.4 2.4e-50 171.5 0.4 1.3 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference Peptidase_M28 PF04389.17 PIK55205.1 - 6.8e-23 81.4 0.0 9.7e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M28 PF04389.17 PIK55206.1 - 5e-15 55.7 0.0 5.6e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M28 Ras PF00071.22 PIK55207.1 - 3.8e-42 143.6 0.7 4.5e-42 143.4 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK55207.1 - 1.4e-19 70.5 0.1 2.3e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK55207.1 - 3.9e-11 42.7 0.7 5.1e-11 42.3 0.2 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK55207.1 - 5.9e-05 22.5 0.1 8e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK55207.1 - 0.00032 20.3 0.1 0.00044 19.9 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Abhydrolase_4 PF08386.10 PIK55207.1 - 0.14 12.2 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Ribosomal_S30 PF04758.14 PIK55208.1 - 8.9e-26 89.9 7.5 1.2e-25 89.4 7.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.23 PIK55208.1 - 1.7e-13 50.1 0.0 2.4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 PIK55208.1 - 1.4e-05 24.9 0.0 1.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK55208.1 - 0.033 14.6 0.0 0.045 14.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Spectrin PF00435.21 PIK55209.1 - 1.3e-213 694.2 179.7 1.4e-19 70.5 0.9 18.0 16 2 2 18 18 18 18 Spectrin repeat Ribosomal_S4 PF00163.19 PIK55209.1 - 7.3 7.6 6.7 17 6.4 0.5 4.2 4 1 0 4 4 4 0 Ribosomal protein S4/S9 N-terminal domain Spectrin PF00435.21 PIK55210.1 - 1.9e-82 272.6 73.1 1.3e-17 64.2 2.6 8.9 8 1 0 8 8 8 8 Spectrin repeat RVT_1 PF00078.27 PIK55210.1 - 2.6e-35 121.9 0.0 5.8e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TadF PF16964.5 PIK55210.1 - 0.97 9.2 5.1 0.35 10.6 0.6 2.5 2 1 1 3 3 3 0 Putative tight adherence pilin protein F Spectrin PF00435.21 PIK55211.1 - 5.9e-32 110.3 20.4 1e-14 54.9 1.6 4.5 4 1 0 4 4 4 3 Spectrin repeat SH3_1 PF00018.28 PIK55211.1 - 7.8e-08 31.8 0.2 2.3e-07 30.3 0.2 1.9 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK55211.1 - 7.3e-07 29.0 0.0 1.5e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 PIK55211.1 - 4.6e-06 26.6 0.0 1.7e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK55211.1 - 2.5e-05 23.9 0.0 5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Tropomyosin_1 PF12718.7 PIK55211.1 - 0.012 15.8 8.0 0.012 15.8 8.0 3.2 3 0 0 3 3 3 0 Tropomyosin like CLZ PF16526.5 PIK55211.1 - 0.28 11.6 8.4 2 8.8 2.6 3.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 PIK55211.1 - 0.79 9.8 17.7 0.34 11.0 10.4 2.9 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 PIK55211.1 - 2.1 7.3 19.2 0.04 13.0 10.0 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc24 PF08286.11 PIK55211.1 - 4.9 7.5 13.1 6 7.2 7.9 3.1 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 DUF5320 PF17253.2 PIK55211.1 - 5 8.3 8.3 12 7.0 0.0 3.2 3 1 1 4 4 3 0 Family of unknown function (DUF5320) DUF465 PF04325.13 PIK55211.1 - 8.9 6.4 9.4 0.62 10.1 1.0 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF465) Spectrin PF00435.21 PIK55212.1 - 1.5e-32 112.2 14.5 2.4e-14 53.7 1.8 3.2 3 0 0 3 3 3 3 Spectrin repeat DUF3106 PF11304.8 PIK55212.1 - 0.0094 16.4 0.2 0.0094 16.4 0.2 3.7 4 1 0 4 4 4 1 Protein of unknown function (DUF3106) DUF5420 PF17457.2 PIK55212.1 - 0.018 14.9 0.4 0.072 13.0 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5420) Endonuc-BglII PF09195.11 PIK55212.1 - 0.047 13.5 2.6 7.5 6.4 0.1 3.2 3 1 0 3 3 3 0 Restriction endonuclease BglII ARGLU PF15346.6 PIK55212.1 - 0.84 9.5 12.9 0.2 11.5 0.3 2.8 3 0 0 3 3 3 0 Arginine and glutamate-rich 1 Peptidase_C14 PF00656.22 PIK55213.1 - 9.6e-32 110.9 1.1 1.4e-31 110.4 1.1 1.2 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 PIK55213.1 - 3.8e-07 30.0 0.1 1.7e-06 28.0 0.0 2.2 3 0 0 3 3 3 1 Caspase recruitment domain Toxin_7 PF05980.12 PIK55213.1 - 0.36 11.1 1.4 0.98 9.7 1.4 1.7 1 0 0 1 1 1 0 Toxin 7 Img2 PF05046.14 PIK55214.1 - 3.8e-19 68.8 0.1 5.7e-19 68.2 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Spectrin PF00435.21 PIK55215.1 - 5.6e-32 110.4 19.0 2.9e-15 56.6 1.1 3.1 3 0 0 3 3 3 3 Spectrin repeat PH_9 PF15410.6 PIK55215.1 - 0.004 17.5 0.0 0.013 15.9 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain CENP-K PF11802.8 PIK55215.1 - 0.012 15.2 1.4 0.012 15.2 1.4 2.1 1 1 1 2 2 2 0 Centromere-associated protein K LPP PF04728.13 PIK55215.1 - 0.018 15.5 3.3 0.039 14.3 1.4 2.5 1 1 1 2 2 2 0 Lipoprotein leucine-zipper GAS PF13851.6 PIK55215.1 - 0.098 12.0 6.4 0.038 13.4 3.7 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 PIK55215.1 - 0.46 10.6 5.8 0.087 12.9 1.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4201 PF13870.6 PIK55215.1 - 0.53 10.0 6.0 1.6 8.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Spectrin PF00435.21 PIK55216.1 - 5.5e-134 438.2 74.6 8.4e-22 77.6 4.3 11.2 10 1 0 10 10 10 8 Spectrin repeat CH PF00307.31 PIK55216.1 - 5.1e-50 168.2 0.9 1.3e-25 89.7 0.1 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK55216.1 - 5e-07 29.5 0.1 5.7e-05 22.9 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain Myb_DNA-bind_4 PF13837.6 PIK55216.1 - 1.7e-05 25.1 8.5 0.00029 21.1 0.0 5.7 6 0 0 6 6 6 1 Myb/SANT-like DNA-binding domain DUF1843 PF08898.10 PIK55216.1 - 0.031 14.8 6.5 5.7 7.5 0.0 5.2 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) Bap31_Bap29_C PF18035.1 PIK55216.1 - 0.065 13.3 2.8 0.2 11.7 0.3 3.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain FAM195 PF14799.6 PIK55216.1 - 0.081 13.3 0.7 0.38 11.1 0.1 2.5 2 0 0 2 2 2 0 FAM195 family DUF1359 PF07097.11 PIK55216.1 - 0.12 12.6 1.7 4.7 7.5 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1359) SKA2 PF16740.5 PIK55216.1 - 9.3 6.1 20.6 0.46 10.3 0.5 6.8 6 1 1 7 7 7 0 Spindle and kinetochore-associated protein 2 Vps39_1 PF10366.9 PIK55217.1 - 3.5e-32 110.9 4.2 3.5e-32 110.9 4.2 3.4 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 PIK55217.1 - 1.4e-27 97.0 0.0 2.5e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 PIK55217.1 - 1.4e-15 57.4 7.4 6.5e-07 29.3 0.0 3.8 3 1 0 3 3 3 2 Region in Clathrin and VPS Vps39_2 PF10367.9 PIK55217.1 - 4.9e-10 39.8 1.3 3.4e-09 37.1 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 BAF PF02961.14 PIK55218.1 - 3.5e-42 142.7 0.0 3.9e-42 142.6 0.0 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.8 PIK55218.1 - 0.00013 22.0 0.0 0.00021 21.4 0.0 1.3 1 0 0 1 1 1 1 IMS family HHH motif DUF1731 PF08338.11 PIK55218.1 - 0.068 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1731) BAF PF02961.14 PIK55220.1 - 1.4e-22 79.9 0.0 1.8e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.8 PIK55220.1 - 6.4e-05 23.0 0.1 9.8e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 IMS family HHH motif Glyco_hydro_1 PF00232.18 PIK55222.1 - 5.9e-44 150.2 0.0 6.8e-44 150.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Sulfotransfer_1 PF00685.27 PIK55223.1 - 8e-34 117.3 5.6 1.6e-32 113.0 5.6 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK55223.1 - 4.6e-05 23.9 0.0 9.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family RVT_1 PF00078.27 PIK55224.1 - 1e-20 74.2 0.0 3.4e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 PIK55225.1 - 4.7e-07 30.4 3.7 5e-07 30.4 2.0 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Conotoxin PF02950.17 PIK55226.1 - 0.37 11.8 2.8 0.32 12.0 0.2 2.3 2 0 0 2 2 2 0 Conotoxin SDA1 PF05285.12 PIK55226.1 - 2 7.8 6.9 3.8 6.8 6.9 1.4 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 PIK55226.1 - 5.6 5.4 6.9 1.1 7.7 3.3 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 PIK55226.1 - 8.6 4.5 10.6 0.04 12.2 1.8 1.4 2 0 0 2 2 2 0 CDC45-like protein RVT_2 PF07727.14 PIK55228.1 - 3.7e-19 69.3 0.1 4.5e-19 69.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5445 PF17520.2 PIK55228.1 - 0.085 12.7 1.5 0.095 12.6 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5445) RHH_3 PF12651.7 PIK55228.1 - 0.091 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix domain HEM4 PF02602.15 PIK55229.1 - 4.2e-30 104.8 0.0 4.8e-30 104.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Hep_core_N PF08290.11 PIK55229.1 - 0.09 12.7 0.1 0.55 10.3 0.1 2.2 2 0 0 2 2 2 0 Hepatitis core protein, putative zinc finger Calx-beta PF03160.14 PIK55230.1 - 9e-32 109.2 22.3 1.3e-08 34.9 0.3 5.2 5 0 0 5 5 5 4 Calx-beta domain 7tm_2 PF00002.24 PIK55230.1 - 4.9e-27 94.8 16.0 7.2e-27 94.2 16.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK55230.1 - 1.7e-12 47.7 1.9 1.7e-12 47.7 1.9 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK55230.1 - 0.0033 16.9 1.2 0.007 15.8 1.2 1.6 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain DUF4843 PF16132.5 PIK55230.1 - 0.0067 16.0 0.1 2.1 7.9 0.0 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4843) DUF485 PF04341.12 PIK55230.1 - 0.03 14.3 0.1 0.12 12.4 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function, DUF485 7tm_1 PF00001.21 PIK55230.1 - 0.049 13.0 12.9 0.05 12.9 11.9 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.5 PIK55230.1 - 0.21 12.3 6.7 0.42 11.3 4.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4728) Calx-beta PF03160.14 PIK55231.1 - 1.1e-11 44.7 2.4 4e-08 33.3 0.2 3.1 3 0 0 3 3 3 3 Calx-beta domain Mal_decarbox_Al PF16957.5 PIK55231.1 - 0.11 10.8 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 Malonate decarboxylase, alpha subunit, transporter tRNA-synt_2b PF00587.25 PIK55232.1 - 1e-38 133.1 0.0 1.5e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 PIK55232.1 - 3.6e-18 65.8 3.3 3.6e-18 65.8 3.3 2.6 2 1 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain VIT PF08487.10 PIK55233.1 - 3.2e-19 69.2 0.1 4.9e-19 68.6 0.1 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain ITI_HC_C PF06668.12 PIK55234.1 - 8.9e-15 54.8 0.5 1.7e-14 54.0 0.0 1.6 2 0 0 2 2 2 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus Rrn6 PF10214.9 PIK55234.1 - 0.47 8.9 9.2 0.63 8.5 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor IHO1 PF15771.5 PIK55234.1 - 3.4 6.3 6.7 4.6 5.9 6.7 1.1 1 0 0 1 1 1 0 Interactor of HORMAD1 protein 1 VIT PF08487.10 PIK55235.1 - 1.3e-22 80.0 1.5 2.9e-22 79.0 1.5 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 PIK55235.1 - 3.4e-15 56.3 0.1 9.4e-15 54.9 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 PIK55235.1 - 7.2e-15 55.7 0.3 1.2e-14 54.9 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain ITI_HC_C PF06668.12 PIK55235.1 - 9e-12 45.0 0.0 2.8e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA_2 PF13519.6 PIK55235.1 - 6.4e-09 36.4 0.3 1.2e-08 35.5 0.3 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 PIK55235.1 - 0.0023 18.0 0.0 0.0045 17.1 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 PIK55235.1 - 0.0033 16.9 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK55237.1 - 1.2e-22 80.5 0.0 1.8e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK55237.1 - 3.1e-19 69.9 0.2 5e-19 69.2 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK55237.1 - 9.7e-16 58.3 0.1 2.3e-15 57.2 0.1 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK55237.1 - 0.0023 17.3 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Copine PF07002.16 PIK55237.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Copine DUF2201 PF09967.9 PIK55237.1 - 0.12 12.6 0.0 0.3 11.2 0.0 1.8 1 1 0 1 1 1 0 VWA-like domain (DUF2201) VIT PF08487.10 PIK55238.1 - 3.4e-24 85.2 2.4 7.4e-24 84.1 2.4 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain ITI_HC_C PF06668.12 PIK55238.1 - 5.1e-20 71.9 0.1 9.7e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA_3 PF13768.6 PIK55238.1 - 4.2e-16 59.3 0.0 6.8e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK55238.1 - 5.7e-14 52.7 0.0 8.9e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK55238.1 - 2.6e-11 44.1 0.0 6.4e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain CobT_C PF11775.8 PIK55238.1 - 0.0095 15.6 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA domain VIT PF08487.10 PIK55239.1 - 4.6e-08 33.2 0.0 9.2e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain ITI_HC_C PF06668.12 PIK55240.1 - 3e-20 72.7 0.0 4.4e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus DUF1412 PF07203.11 PIK55240.1 - 0.071 13.3 0.3 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1412) VIT PF08487.10 PIK55241.1 - 0.00011 22.3 0.3 0.00024 21.3 0.3 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 PIK55241.1 - 0.002 18.0 0.0 0.0048 16.8 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain EGF_3 PF12947.7 PIK55242.1 - 3.1e-35 120.1 143.2 4.1e-09 36.5 4.7 13.2 12 0 0 12 12 12 10 EGF domain EGF_CA PF07645.15 PIK55242.1 - 3.2e-28 97.6 76.7 7.5e-09 35.7 12.8 13.1 13 1 0 14 14 14 5 Calcium-binding EGF domain cEGF PF12662.7 PIK55242.1 - 3.2e-24 84.5 105.9 3.8e-06 26.7 0.5 13.1 11 2 0 11 11 11 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK55242.1 - 8.6e-09 35.5 36.7 1.6e-06 28.3 9.6 12.5 11 1 1 12 12 12 4 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK55242.1 - 2.2e-05 24.4 31.4 0.00057 19.9 7.3 10.3 10 0 0 10 10 10 3 MSP1 EGF domain 1 EGF PF00008.27 PIK55242.1 - 3.1e-05 24.2 152.6 0.0024 18.2 6.9 14.6 13 1 0 13 13 13 7 EGF-like domain EGF_2 PF07974.13 PIK55242.1 - 0.0016 18.8 7.8 0.0016 18.8 7.8 11.7 10 1 1 11 11 11 2 EGF-like domain PQQ PF01011.21 PIK55242.1 - 0.023 14.6 0.4 0.07 13.1 0.4 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat Plasmod_Pvs28 PF06247.11 PIK55242.1 - 0.091 13.1 90.3 0.021 15.1 3.6 8.5 8 1 0 8 8 8 0 Pvs28 EGF domain DUF4550 PF15084.6 PIK55243.1 - 2.5e-40 136.8 0.2 4.2e-40 136.1 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4550) DUF3450 PF11932.8 PIK55243.1 - 0.022 14.1 0.1 0.039 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) GST_C_6 PF17171.4 PIK55243.1 - 0.068 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CAGE1 PF15066.6 PIK55243.1 - 0.41 9.3 3.2 0.59 8.7 3.2 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family DUF5137 PF17220.3 PIK55246.1 - 0.061 14.2 0.6 1.1 10.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) FLYWCH PF04500.16 PIK55247.1 - 6.6e-15 55.0 0.0 0.0031 17.6 0.0 3.5 3 0 0 3 3 3 3 FLYWCH zinc finger domain MULE PF10551.9 PIK55247.1 - 8.3e-08 32.5 0.0 1.9e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain PFU PF09070.11 PIK55247.1 - 0.0004 20.6 0.1 11 6.3 0.0 3.6 4 0 0 4 4 4 2 PFU (PLAA family ubiquitin binding) PSD5 PF07637.11 PIK55247.1 - 0.015 15.6 3.4 4.7 7.6 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) CC2-LZ PF16516.5 PIK55248.1 - 5e-09 36.4 18.1 1.6e-08 34.8 17.7 2.2 1 1 0 1 1 1 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CENP-F_leu_zip PF10473.9 PIK55248.1 - 0.0011 19.0 22.8 0.031 14.3 13.2 3.0 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 PIK55248.1 - 0.0064 14.7 7.1 0.0064 14.7 7.1 2.0 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA ERM PF00769.19 PIK55248.1 - 0.015 15.1 13.1 0.015 15.1 13.1 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4127 PF13552.6 PIK55248.1 - 0.065 11.8 4.5 0.04 12.5 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4127) Golgin_A5 PF09787.9 PIK55248.1 - 0.14 11.6 25.4 0.87 9.0 10.1 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Tox-ODYAM1 PF15642.6 PIK55248.1 - 0.26 10.2 10.3 0.038 13.0 6.2 1.6 1 1 1 2 2 2 0 Toxin in Odyssella and Amoebophilus DUF3552 PF12072.8 PIK55248.1 - 0.55 9.6 21.7 0.81 9.1 21.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Sec2p PF06428.11 PIK55248.1 - 1 9.4 24.2 1.8 8.6 2.7 3.1 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p KASH_CCD PF14662.6 PIK55248.1 - 5.8 6.7 24.9 13 5.5 14.5 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.9 PIK55248.1 - 6.1 5.8 22.9 0.84 8.7 11.4 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HALZ PF02183.18 PIK55249.1 - 0.0033 17.6 3.0 0.0033 17.6 3.0 4.7 5 1 1 6 6 5 1 Homeobox associated leucine zipper SWI-SNF_Ssr4 PF08549.10 PIK55249.1 - 0.0039 15.9 13.5 0.0046 15.7 13.5 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Baculo_PEP_C PF04513.12 PIK55249.1 - 0.012 15.7 11.7 0.047 13.7 2.0 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 PIK55249.1 - 0.018 15.1 43.5 0.13 12.3 12.0 3.5 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 PIK55249.1 - 0.019 14.7 5.5 0.019 14.7 5.5 4.5 2 2 2 4 4 4 0 Septum formation initiator bZIP_2 PF07716.15 PIK55249.1 - 0.02 15.0 3.8 0.02 15.0 3.8 5.3 4 2 4 8 8 8 0 Basic region leucine zipper Phosphoesterase PF04185.14 PIK55249.1 - 0.033 13.4 4.8 0.046 12.9 4.8 1.2 1 0 0 1 1 1 0 Phosphoesterase family Tropomyosin PF00261.20 PIK55249.1 - 0.049 13.0 32.6 0.017 14.5 29.4 1.7 2 0 0 2 2 2 0 Tropomyosin Bacillus_HBL PF05791.11 PIK55249.1 - 0.05 13.4 25.4 0.45 10.3 9.9 3.0 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Occludin_ELL PF07303.13 PIK55249.1 - 0.17 12.7 26.7 0.11 13.3 10.7 2.8 2 1 0 2 2 2 0 Occludin homology domain DUF3584 PF12128.8 PIK55249.1 - 0.21 9.1 31.9 0.29 8.6 31.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HOOK PF05622.12 PIK55249.1 - 0.26 9.4 34.7 0.27 9.3 11.7 2.2 1 1 1 2 2 2 0 HOOK protein GAS PF13851.6 PIK55249.1 - 0.28 10.5 41.6 0.27 10.5 23.4 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MAD PF05557.13 PIK55249.1 - 0.29 9.4 41.1 4 5.7 21.9 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 PIK55249.1 - 0.3 11.1 40.8 4.1 7.4 24.1 3.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CorA PF01544.18 PIK55249.1 - 0.34 10.2 7.4 0.1 11.9 0.8 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Fez1 PF06818.15 PIK55249.1 - 0.5 10.8 34.5 2.2 8.7 14.5 2.2 1 1 1 2 2 2 0 Fez1 TACC_C PF05010.14 PIK55249.1 - 0.59 9.9 36.5 0.98 9.2 20.4 2.8 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 PIK55249.1 - 0.86 9.1 35.8 0.3 10.6 14.1 2.6 1 1 0 2 2 2 0 Intermediate filament protein Nmad5 PF18757.1 PIK55249.1 - 0.88 9.7 17.6 1.7 8.8 17.5 1.6 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 Spc7 PF08317.11 PIK55249.1 - 0.95 8.3 38.4 8.8 5.1 3.5 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 PIK55249.1 - 1 9.5 33.8 0.092 12.9 6.9 5.4 2 2 2 4 4 4 0 bZIP transcription factor ATG16 PF08614.11 PIK55249.1 - 1.2 9.3 38.2 0.68 10.1 29.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 PIK55249.1 - 1.4 9.4 19.2 5.7 7.4 0.8 5.2 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) PI3K_P85_iSH2 PF16454.5 PIK55249.1 - 1.6 8.3 31.9 2.1 7.9 29.7 2.4 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PRKG1_interact PF15898.5 PIK55249.1 - 2 9.4 35.4 0.35 11.8 13.7 3.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Phlebovirus_NSM PF07246.11 PIK55249.1 - 2.2 7.6 26.7 1.5 8.1 9.7 2.1 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M TSC22 PF01166.18 PIK55249.1 - 3.5 8.0 22.0 0.32 11.4 1.5 4.6 3 2 2 5 5 5 0 TSC-22/dip/bun family ADIP PF11559.8 PIK55249.1 - 4 7.5 38.4 3.3 7.8 15.6 2.5 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 PIK55249.1 - 4.3 7.9 41.8 5e+02 1.2 33.6 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Lebercilin PF15619.6 PIK55249.1 - 4.7 6.8 38.7 0.054 13.1 14.4 2.9 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fungal_TACC PF12709.7 PIK55249.1 - 4.9 7.7 38.2 4.6 7.7 9.6 4.6 1 1 3 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Golgin_A5 PF09787.9 PIK55249.1 - 5.5 6.4 36.1 7.5 5.9 13.4 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 EOS1 PF12326.8 PIK55249.1 - 5.6 6.9 8.4 1.6 8.6 2.5 2.1 2 0 0 2 2 2 0 N-glycosylation protein Rootletin PF15035.6 PIK55249.1 - 6.2 6.8 34.3 5.7 6.9 15.7 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DivIVA PF05103.13 PIK55249.1 - 7.1 6.7 34.0 8.2 6.5 5.5 3.8 1 1 3 4 4 4 0 DivIVA protein DUF1664 PF07889.12 PIK55249.1 - 7.4 6.6 23.1 2.7 8.0 2.0 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Phage_GPO PF05929.11 PIK55249.1 - 9.8 5.7 26.2 3 7.4 12.7 2.4 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase RVT_2 PF07727.14 PIK55250.1 - 2.7e-35 122.2 0.0 3.2e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 PIK55251.1 - 3.9e-20 71.9 0.1 6.8e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 PIK55251.1 - 1.8e-11 44.3 0.0 2.5e-10 40.6 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 PIK55251.1 - 1.6e-06 27.9 0.1 5.5e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 GAG-pre-integrase domain zf-CCHC PF00098.23 PIK55251.1 - 2e-05 24.4 0.6 6.4e-05 22.8 0.6 1.9 1 0 0 1 1 1 1 Zinc knuckle TerY_C PF15616.6 PIK55251.1 - 0.013 15.6 0.4 0.044 13.9 0.1 2.0 2 0 0 2 2 2 0 TerY-C metal binding domain Glyoxalase_2 PF12681.7 PIK55251.1 - 0.068 13.1 0.3 3.4 7.6 0.1 2.8 1 1 2 3 3 3 0 Glyoxalase-like domain DIX PF00778.17 PIK55251.1 - 0.19 11.6 0.8 0.72 9.7 0.1 2.1 2 0 0 2 2 2 0 DIX domain Nucleotid_trans PF03407.16 PIK55252.1 - 2.6e-28 99.4 0.1 5.1e-28 98.5 0.0 1.5 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase PI3K_P85_iSH2 PF16454.5 PIK55252.1 - 0.2 11.2 0.9 5.1 6.7 0.1 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Abhydrolase_6 PF12697.7 PIK55253.1 - 2.8e-13 51.0 0.0 3.7e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 PIK55253.1 - 7e-12 45.5 0.1 6.5e-11 42.4 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 PIK55253.1 - 0.002 17.2 0.0 0.0032 16.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.8 PIK55253.1 - 0.0024 17.2 0.0 0.013 14.8 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 TSGA13 PF14994.6 PIK55254.1 - 3.9e-25 88.8 5.1 5.1e-25 88.4 5.1 1.2 1 0 0 1 1 1 1 Testis-specific gene 13 protein Arf PF00025.21 PIK55255.1 - 1.9e-59 200.1 0.5 6.3e-58 195.1 0.5 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK55255.1 - 1.9e-13 50.7 0.2 3.5e-13 49.8 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK55255.1 - 6.9e-12 45.2 1.4 2.1e-08 33.8 0.3 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 PIK55255.1 - 5.4e-11 42.3 0.1 2.8e-10 39.9 0.1 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 PIK55255.1 - 3.6e-10 39.6 0.1 7.1e-10 38.6 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK55255.1 - 3.1e-09 36.6 0.2 5.5e-09 35.8 0.2 1.5 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 PIK55255.1 - 7.4e-05 22.8 0.1 0.00015 21.8 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK55255.1 - 0.0097 15.2 0.1 0.017 14.4 0.1 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase SRP54 PF00448.22 PIK55255.1 - 0.11 12.1 0.2 0.7 9.5 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain TMEM43 PF07787.12 PIK55256.1 - 2.5e-26 92.6 0.9 4.7e-26 91.7 0.9 1.4 1 0 0 1 1 1 1 Transmembrane protein 43 MAP PF03642.13 PIK55257.1 - 0.27 11.5 4.0 0.61 10.4 4.0 1.5 1 0 0 1 1 1 0 MAP domain TPH PF13868.6 PIK55257.1 - 0.92 8.0 19.9 0.082 11.4 15.2 1.5 2 0 0 2 2 2 0 Trichohyalin-plectin-homology domain Aldedh PF00171.22 PIK55258.1 - 2.2e-85 286.9 2.4 2.7e-85 286.6 2.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 PIK55259.1 - 6.3e-45 153.5 0.1 7.6e-45 153.3 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Phage_ABA_S PF18066.1 PIK55259.1 - 0.00035 21.2 0.0 0.00056 20.5 0.0 1.4 1 0 0 1 1 1 1 Phage ABA sandwich domain AT_hook PF02178.19 PIK55260.1 - 0.0004 19.9 60.3 0.38 10.8 2.9 5.8 5 0 0 5 5 5 5 AT hook motif Abhydrolase_1 PF00561.20 PIK55261.1 - 1.5e-11 44.4 0.1 1.6e-09 37.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK55261.1 - 5.6e-08 33.6 0.1 7.7e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK55261.1 - 3.2e-07 29.8 0.0 7.1e-07 28.7 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DALR_1 PF05746.15 PIK55262.1 - 3e-15 56.4 0.0 8.6e-15 55.0 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain DUF501 PF04417.12 PIK55262.1 - 0.16 11.8 0.2 0.36 10.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Ank_2 PF12796.7 PIK55264.1 - 3.5e-38 130.1 3.8 2.1e-13 50.7 0.2 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK55264.1 - 2.3e-35 120.5 5.3 3.8e-09 36.9 0.4 6.2 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK55264.1 - 1.2e-33 111.3 0.6 9.2e-05 22.6 0.0 7.5 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 PIK55264.1 - 1.2e-28 98.8 15.9 4.1e-07 30.2 0.0 6.9 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 PIK55264.1 - 8.3e-28 95.6 11.1 0.0019 18.5 0.2 7.2 7 0 0 7 7 7 7 Ankyrin repeat Acyltransferase PF01553.21 PIK55265.1 - 6.8e-25 87.2 0.0 9.2e-25 86.8 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase TFIIIC_sub6 PF10419.9 PIK55266.1 - 6.3e-13 48.4 0.0 7.8e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain G-patch PF01585.23 PIK55267.1 - 2e-12 46.8 0.3 2e-12 46.8 0.3 2.1 2 0 0 2 2 2 1 G-patch domain RRM_1 PF00076.22 PIK55267.1 - 0.00039 20.2 0.2 0.00072 19.3 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 PIK55269.1 - 4.9e-22 78.6 0.0 3.1e-19 69.4 0.0 3.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55269.1 - 5.8e-21 74.9 0.0 8.8e-10 38.3 0.0 2.9 2 1 1 3 3 3 2 Protein tyrosine kinase Rx_N PF18052.1 PIK55269.1 - 0.16 12.3 2.3 1.2 9.4 1.1 2.7 2 0 0 2 2 2 0 Rx N-terminal domain DUF445 PF04286.12 PIK55269.1 - 1.3 8.7 11.5 0.27 11.0 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Spore_III_AB PF09548.10 PIK55269.1 - 1.8 8.7 10.2 0.42 10.7 2.5 2.5 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Kazal_2 PF07648.15 PIK55270.1 - 3.6e-27 94.2 20.2 3.9e-09 36.5 5.4 3.4 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK55270.1 - 2.5e-24 85.0 20.2 3.9e-08 33.2 4.3 3.3 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain LEM PF03020.15 PIK55271.1 - 1.6e-15 56.4 0.5 1.6e-15 56.4 0.5 2.0 2 0 0 2 2 2 1 LEM domain Thymopoietin PF08198.11 PIK55271.1 - 1e-07 31.4 3.1 2.4e-06 27.0 0.5 2.8 3 0 0 3 3 3 1 Thymopoietin protein HeH PF12949.7 PIK55271.1 - 5.3e-06 26.0 0.4 5.3e-06 26.0 0.4 1.9 2 0 0 2 2 2 1 HeH/LEM domain Nop14 PF04147.12 PIK55271.1 - 0.00086 17.7 14.6 0.001 17.4 14.6 1.2 1 0 0 1 1 1 1 Nop14-like family DUF3311 PF11755.8 PIK55271.1 - 0.068 13.1 3.3 0.14 12.2 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) CENP-B_dimeris PF09026.10 PIK55271.1 - 0.25 11.7 15.4 0.66 10.4 15.4 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 PIK55271.1 - 0.35 8.9 18.6 0.22 9.6 16.2 1.7 2 0 0 2 2 2 0 DNA polymerase phi Sporozoite_P67 PF05642.11 PIK55271.1 - 0.51 8.4 9.7 0.83 7.7 9.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SAP PF02037.27 PIK55271.1 - 0.82 9.5 3.2 1.3 8.8 0.5 2.2 2 0 0 2 2 2 0 SAP domain Astro_capsid_p PF12226.8 PIK55271.1 - 1.6 7.8 16.5 4.4 6.3 15.4 2.0 2 0 0 2 2 2 0 Turkey astrovirus capsid protein eIF-3c_N PF05470.12 PIK55271.1 - 2.5 6.3 13.4 3.8 5.7 13.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Voldacs PF03517.13 PIK55271.1 - 9.2 6.4 13.2 21 5.2 13.2 1.5 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Exo_endo_phos PF03372.23 PIK55272.1 - 1.5e-05 24.7 0.0 1.6e-05 24.5 0.0 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Intron_maturas2 PF01348.21 PIK55272.1 - 0.17 11.8 0.0 0.21 11.6 0.0 1.1 1 0 0 1 1 1 0 Type II intron maturase zf-GRF PF06839.12 PIK55273.1 - 1.2e-10 41.3 4.0 3.4e-10 39.8 4.0 1.8 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos PF03372.23 PIK55273.1 - 7e-06 25.7 0.1 1.2e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK55273.1 - 0.00047 20.0 0.1 0.07 13.0 0.1 2.5 1 1 1 2 2 2 2 Endonuclease-reverse transcriptase PRO8NT PF08082.11 PIK55274.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain 7tm_1 PF00001.21 PIK55276.1 - 4.2e-32 111.5 7.5 4.2e-32 111.5 7.5 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55276.1 - 7.2e-08 32.4 12.6 7.2e-08 32.4 12.6 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK55276.1 - 0.0021 17.9 16.1 0.015 15.1 16.1 2.0 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK55276.1 - 0.98 8.7 17.7 24 4.2 17.7 2.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx UDPGT PF00201.18 PIK55277.1 - 7.9e-96 321.8 0.0 1e-95 321.4 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK55277.1 - 0.023 14.7 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain CLASP_N PF12348.8 PIK55277.1 - 0.079 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 CLASP N terminal Lipin_N PF04571.14 PIK55279.1 - 2.5e-33 114.1 0.0 2.9e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 lipin, N-terminal conserved region DUF1930 PF09122.10 PIK55279.1 - 0.11 12.5 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) Lipin_mid PF16876.5 PIK55280.1 - 3.3e-29 101.0 0.2 1.6e-28 98.8 0.0 2.1 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain PAXIP1_C PF15364.6 PIK55280.1 - 0.02 15.2 1.5 0.02 15.2 1.5 2.3 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein LNS2 PF08235.13 PIK55281.1 - 1.1e-67 227.9 0.0 1.3e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) WRNPLPNID PF15017.6 PIK55281.1 - 0.00013 22.8 0.0 0.00022 22.0 0.0 1.3 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box Lectin_C PF00059.21 PIK55283.1 - 1.2e-20 74.3 0.8 2.4e-20 73.3 0.8 1.5 1 0 0 1 1 1 1 Lectin C-type domain CUB PF00431.20 PIK55283.1 - 1.2e-07 32.0 0.0 1.6e-06 28.4 0.0 2.3 1 1 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 PIK55283.1 - 1.9e-07 31.2 0.5 5.6e-07 29.7 0.5 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A UL45 PF05473.12 PIK55283.1 - 0.0022 17.6 0.1 0.0031 17.2 0.1 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like PRKCSH-like PF12999.7 PIK55283.1 - 0.0081 16.0 0.2 0.014 15.2 0.2 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like T-box PF00907.22 PIK55284.1 - 3.6e-55 187.1 0.8 3.6e-55 187.1 0.8 1.5 2 0 0 2 2 2 1 T-box fn3 PF00041.21 PIK55284.1 - 0.042 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Fibronectin type III domain Pneumo_att_G PF05539.11 PIK55284.1 - 0.56 9.7 3.6 0.83 9.2 3.6 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Amino_oxidase PF01593.24 PIK55285.1 - 5.7e-86 289.6 0.0 9.7e-86 288.8 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK55285.1 - 2.7e-12 46.8 0.1 5.7e-12 45.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 PIK55285.1 - 3.1e-10 39.8 0.2 8.5e-06 25.2 0.1 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase SWIRM PF04433.17 PIK55285.1 - 1.1e-09 38.5 0.0 3.2e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain HI0933_like PF03486.14 PIK55285.1 - 1.8e-08 33.5 1.4 7.5e-06 24.9 0.2 2.3 2 0 0 2 2 2 2 HI0933-like protein zf-CW PF07496.15 PIK55285.1 - 6.7e-08 32.4 4.0 6.7e-08 32.4 4.0 2.0 2 0 0 2 2 1 1 CW-type Zinc Finger Pyr_redox_3 PF13738.6 PIK55285.1 - 5.9e-07 29.0 0.5 0.0022 17.3 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK55285.1 - 4.9e-06 25.9 0.0 8.7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 PIK55285.1 - 7.4e-06 26.4 2.0 0.00026 21.5 0.3 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK55285.1 - 1.1e-05 25.2 0.4 6.5e-05 22.7 0.9 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK55285.1 - 1.4e-05 25.1 0.3 0.02 14.9 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 PIK55285.1 - 2.4e-05 23.6 0.5 5.1e-05 22.5 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 PIK55285.1 - 3e-05 23.3 0.4 0.0025 16.9 0.4 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 PIK55285.1 - 0.00059 19.2 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 PIK55285.1 - 0.00073 19.0 0.8 0.001 18.6 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK55285.1 - 0.0045 16.1 1.5 0.015 14.4 0.3 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 PIK55285.1 - 0.022 14.1 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 PIK55285.1 - 0.026 13.8 0.0 0.22 10.7 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.20 PIK55285.1 - 0.031 14.4 0.1 0.068 13.2 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase YjeF_N PF03853.15 PIK55285.1 - 0.046 13.6 0.1 0.096 12.6 0.1 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus CUB PF00431.20 PIK55286.1 - 3.2e-38 130.4 0.1 2.2e-09 37.6 0.0 5.1 5 0 0 5 5 5 5 CUB domain Ldl_recept_a PF00057.18 PIK55286.1 - 1.8e-14 53.7 44.9 4.7e-05 23.5 8.4 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A zf-C3HC4_4 PF15227.6 PIK55287.1 - 4e-07 30.1 11.9 7.5e-07 29.2 11.9 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 PIK55287.1 - 4.4e-07 29.8 12.5 8.9e-07 28.8 12.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK55287.1 - 0.00011 22.0 16.8 0.00022 21.1 16.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK55287.1 - 0.00017 21.4 15.0 0.00017 21.4 15.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF4515 PF14988.6 PIK55287.1 - 0.013 15.3 8.2 0.02 14.7 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) zf-RING_10 PF16685.5 PIK55287.1 - 0.015 15.4 6.2 0.035 14.3 6.2 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF4362 PF14275.6 PIK55287.1 - 0.025 14.9 1.5 0.21 11.9 1.5 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4362) zf-C3HC4_2 PF13923.6 PIK55287.1 - 0.029 14.2 14.3 0.066 13.1 14.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK55287.1 - 0.13 12.7 13.4 0.31 11.4 13.4 1.7 1 0 0 1 1 1 0 Ring finger domain DegS PF05384.11 PIK55287.1 - 0.24 10.9 7.1 0.44 10.0 7.0 1.4 1 1 0 1 1 1 0 Sensor protein DegS zf-RING_4 PF14570.6 PIK55287.1 - 0.28 11.0 10.8 16 5.4 9.7 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain V-SNARE PF05008.15 PIK55287.1 - 1.4 9.4 6.0 1.2 9.5 3.7 2.0 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Prok-RING_4 PF14447.6 PIK55287.1 - 7.8 6.4 14.9 21 5.1 14.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 EF-hand_1 PF00036.32 PIK55288.1 - 1.1e-19 68.4 0.2 0.00018 20.8 0.0 4.9 4 1 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 PIK55288.1 - 7.7e-17 61.5 0.1 7.1e-07 29.6 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK55288.1 - 1.2e-16 59.4 0.3 0.0053 16.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 PIK55288.1 - 3.1e-16 57.9 0.1 0.0003 20.5 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 PIK55288.1 - 1e-12 47.7 0.1 7.8e-09 35.3 0.0 3.6 3 1 1 4 4 4 1 EF-hand domain pair GUN4 PF05419.12 PIK55288.1 - 0.02 14.9 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 GUN4-like Caleosin PF05042.13 PIK55288.1 - 0.052 13.5 0.1 1.2 9.0 0.0 2.7 1 1 2 3 3 3 0 Caleosin related protein Toprim_2 PF13155.6 PIK55288.1 - 0.13 12.7 0.0 16 6.0 0.0 2.7 1 1 2 3 3 3 0 Toprim-like Abhydrolase_1 PF00561.20 PIK55289.1 - 3.4e-08 33.4 0.0 3.9e-08 33.3 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK55289.1 - 0.001 19.7 0.0 0.001 19.7 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family EHN PF06441.12 PIK55289.1 - 0.05 14.0 0.4 0.089 13.2 0.4 1.4 1 0 0 1 1 1 0 Epoxide hydrolase N terminus p450 PF00067.22 PIK55290.1 - 4.8e-70 236.6 0.0 4.4e-55 187.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 zf-RING_UBOX PF13445.6 PIK55292.1 - 8.5e-09 35.3 5.8 8.5e-09 35.3 5.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK55292.1 - 6.8e-08 32.7 12.5 6.8e-08 32.7 12.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK55292.1 - 5.5e-07 29.4 12.4 5.5e-07 29.4 12.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-B_box PF00643.24 PIK55292.1 - 5.8e-07 29.6 5.7 5.8e-07 29.6 5.7 2.9 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4 PF00097.25 PIK55292.1 - 2.9e-05 23.9 13.5 2.9e-05 23.9 13.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK55292.1 - 0.00042 20.1 14.8 0.00042 20.1 14.8 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK55292.1 - 0.014 15.2 6.8 0.041 13.6 6.8 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 PIK55292.1 - 0.035 14.1 5.0 0.096 12.7 5.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger NHL PF01436.21 PIK55292.1 - 0.27 11.4 0.9 15 5.9 0.2 3.2 3 0 0 3 3 3 0 NHL repeat zf-C3HC4_4 PF15227.6 PIK55292.1 - 1.3 9.2 20.7 0.055 13.6 11.5 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 PIK55292.1 - 1.6 8.9 15.6 0.35 11.0 8.9 2.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 PIK55292.1 - 5.6 7.3 17.0 0.11 12.7 8.1 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain Mit_KHE1 PF10173.9 PIK55293.1 - 0.055 13.6 0.1 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Patched PF02460.18 PIK55295.1 - 3.1e-21 75.2 3.4 4e-21 74.8 3.4 1.1 1 0 0 1 1 1 1 Patched family PTP2 PF17022.5 PIK55295.1 - 0.18 11.4 1.0 0.3 10.6 1.0 1.3 1 0 0 1 1 1 0 Polar tube protein 2 from Microsporidia Retrotrans_gag PF03732.17 PIK55296.1 - 6.3e-05 23.2 0.2 0.00035 20.8 0.1 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_6 PF15288.6 PIK55296.1 - 0.002 17.9 1.1 0.0046 16.8 1.1 1.6 1 0 0 1 1 1 1 Zinc knuckle DUF1759 PF03564.15 PIK55296.1 - 0.0049 16.8 0.2 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) zf-CCHC PF00098.23 PIK55296.1 - 0.006 16.6 2.9 0.011 15.7 2.9 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF86 PF01934.17 PIK55296.1 - 0.052 13.4 0.4 0.16 11.9 0.1 1.7 1 1 0 2 2 2 0 Protein of unknown function DUF86 SCAN PF02023.17 PIK55296.1 - 0.078 12.8 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 SCAN domain RT_RNaseH_2 PF17919.1 PIK55297.1 - 5.7e-35 119.4 0.0 1.1e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55297.1 - 9e-35 119.1 0.1 1.6e-34 118.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55297.1 - 2.7e-29 102.3 0.0 4.2e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 PIK55297.1 - 0.0011 19.2 0.0 0.73 9.9 0.0 2.4 1 1 1 2 2 2 2 Spumavirus aspartic protease (A9) rve PF00665.26 PIK55298.1 - 4.9e-25 88.0 0.0 1.2e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK55298.1 - 1.9e-05 24.4 0.0 0.00092 18.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Nup192 PF11894.8 PIK55299.1 - 7.1e-108 361.6 0.0 9e-108 361.3 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Nup192 PF11894.8 PIK55300.1 - 3.1e-87 293.2 6.8 3.7e-52 176.9 1.1 2.4 2 1 1 3 3 3 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 IL17 PF06083.11 PIK55302.1 - 6.9e-16 58.5 2.6 1.2e-15 57.7 2.6 1.4 1 0 0 1 1 1 1 Interleukin-17 ubiquitin PF00240.23 PIK55303.1 - 1.7e-33 114.2 0.3 4.8e-23 80.7 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK55303.1 - 6.8e-12 45.0 0.2 1.3e-07 31.3 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK55303.1 - 0.00055 20.3 0.4 0.094 13.2 0.1 2.7 2 1 0 2 2 2 1 Ubiquitin-like domain Big_7 PF17957.1 PIK55303.1 - 0.00061 20.5 0.1 0.62 10.9 0.0 2.2 2 0 0 2 2 2 2 Bacterial Ig domain FlgD_ig PF13860.6 PIK55303.1 - 0.014 15.3 0.2 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 FlgD Ig-like domain rve PF00665.26 PIK55305.1 - 1.1e-13 51.4 0.1 3.2e-13 49.9 0.1 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 PIK55305.1 - 7.8e-06 25.7 0.3 1.7e-05 24.7 0.3 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DDE_Tnp_IS240 PF13610.6 PIK55305.1 - 0.0018 18.5 0.9 0.0039 17.4 0.9 1.6 1 0 0 1 1 1 1 DDE domain Mtf2_C PF14061.6 PIK55305.1 - 0.11 12.7 0.3 0.39 10.9 0.3 2.0 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Plant_zn_clust PF10533.9 PIK55305.1 - 0.29 11.1 3.4 0.7 9.9 3.4 1.6 1 0 0 1 1 1 0 Plant zinc cluster domain zf-C2H2 PF00096.26 PIK55306.1 - 8.4e-07 29.1 17.0 0.00046 20.5 0.8 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55306.1 - 0.0021 18.7 14.1 0.0026 18.5 0.6 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK55306.1 - 0.022 15.0 1.8 0.046 14.0 1.8 1.5 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 PIK55306.1 - 0.027 14.2 4.6 2 8.3 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-met PF12874.7 PIK55306.1 - 0.27 11.7 1.8 25 5.4 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK55306.1 - 1.2 8.9 5.6 1.8 8.4 0.6 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK55306.1 - 3.9 7.9 7.5 17 5.8 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DNA_pol_B_2 PF03175.13 PIK55307.1 - 0.037 12.9 0.0 0.051 12.4 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral ubiquitin PF00240.23 PIK55308.1 - 6.9e-48 160.3 0.6 7e-23 80.2 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK55308.1 - 7.7e-15 54.5 0.3 2.4e-07 30.5 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK55308.1 - 9.3e-06 26.0 0.6 0.14 12.7 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Big_7 PF17957.1 PIK55308.1 - 0.0011 19.7 0.1 1.1 10.0 0.0 2.3 2 0 0 2 2 2 2 Bacterial Ig domain TBK1_ULD PF18396.1 PIK55308.1 - 0.0032 17.4 0.1 3 7.8 0.0 2.8 2 1 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK55308.1 - 0.013 15.8 0.1 5.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain FlgD_ig PF13860.6 PIK55308.1 - 0.026 14.4 0.2 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain Rad60-SLD_2 PF13881.6 PIK55308.1 - 0.036 14.2 0.0 5.2 7.2 0.0 2.7 2 2 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 PIK55308.1 - 0.37 10.9 2.8 18 5.5 0.0 3.4 4 0 0 4 4 4 0 Ubiquitin-like domain DUF4402 PF14352.6 PIK55309.1 - 0.00025 21.7 0.1 1 10.0 0.3 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4402) Vps62 PF06101.11 PIK55310.1 - 4.2e-18 64.9 0.0 6.8e-13 47.8 0.0 2.5 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 62 ETX_MTX2 PF03318.13 PIK55310.1 - 2.2e-06 27.6 3.8 3.3e-06 27.0 3.8 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK55310.1 - 5.8e-06 25.8 1.0 1e-05 25.0 1.0 1.3 1 0 0 1 1 1 1 Aerolysin toxin SBP_bac_3 PF00497.20 PIK55311.1 - 3e-14 53.0 0.0 8.1e-14 51.6 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 adh_short PF00106.25 PIK55312.1 - 5.5e-39 133.6 0.0 8.2e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK55312.1 - 1.1e-21 77.5 0.0 1.7e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK55312.1 - 6.6e-06 26.1 0.0 1.4e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 KR domain zf-C3HC4 PF00097.25 PIK55313.1 - 3.3e-11 42.9 5.4 3.3e-11 42.9 5.4 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK55313.1 - 1e-10 41.5 2.9 1e-10 41.5 2.9 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK55313.1 - 1.9e-08 34.0 7.7 1.9e-08 34.0 7.7 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK55313.1 - 2.1e-08 34.4 7.3 2.1e-08 34.4 7.3 2.8 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK55313.1 - 2e-07 30.8 9.3 2e-07 30.8 9.3 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK55313.1 - 4.3e-07 30.0 7.1 4.3e-07 30.0 7.1 2.7 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK55313.1 - 4.6e-06 26.5 7.2 4.6e-06 26.5 7.2 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 PIK55313.1 - 0.0012 18.5 5.8 0.0012 18.5 5.8 2.6 1 1 1 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 PIK55313.1 - 0.0027 17.5 10.2 0.0027 17.5 10.2 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Condensin2nSMC PF12422.8 PIK55313.1 - 0.0088 16.2 1.4 0.21 11.8 0.5 2.3 2 0 0 2 2 2 1 Condensin II non structural maintenance of chromosomes subunit DUF2587 PF10759.9 PIK55313.1 - 0.18 11.3 1.5 0.28 10.7 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) NPFF PF15085.6 PIK55315.1 - 0.11 12.9 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 Neuropeptide FF PBP_N PF17093.5 PIK55315.1 - 0.33 11.2 3.5 0.76 10.0 3.5 1.6 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus TPR_2 PF07719.17 PIK55316.1 - 4.1e-13 48.4 12.3 0.34 11.1 0.1 8.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK55316.1 - 5.1e-10 38.7 15.1 0.0049 16.6 0.3 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55316.1 - 3.8e-05 23.9 6.9 1.1 9.6 0.3 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK55316.1 - 0.00017 21.4 2.8 0.36 11.0 0.1 4.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55316.1 - 0.00031 21.3 0.8 9.6 7.3 0.0 5.8 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55316.1 - 0.0012 18.5 0.9 0.062 13.0 0.0 4.0 5 0 0 5 5 5 1 TPR repeat TPR_17 PF13431.6 PIK55316.1 - 0.0053 17.1 5.0 53 4.5 0.0 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55316.1 - 0.0073 16.9 2.6 17 6.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55316.1 - 0.014 15.6 13.9 1.7 9.1 0.2 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK55316.1 - 0.018 15.3 0.5 24 5.2 0.1 4.2 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 PIK55316.1 - 0.29 11.1 5.5 4.8 7.2 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK55316.1 - 3 8.7 3.6 1.5e+02 3.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5512 PF17631.2 PIK55317.1 - 0.0025 17.8 1.0 0.0075 16.3 1.0 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5512) LIM PF00412.22 PIK55318.1 - 1.9e-10 40.8 1.5 2.5e-10 40.4 1.5 1.1 1 0 0 1 1 1 1 LIM domain Peptidase_S7 PF00949.21 PIK55318.1 - 0.016 15.0 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease ABC_membrane PF00664.23 PIK55319.1 - 2.8e-34 119.0 3.7 1e-33 117.2 3.7 1.8 1 1 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK55319.1 - 1.2e-08 35.5 0.0 3.7e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter Cuticle_1 PF08140.11 PIK55319.1 - 0.086 12.9 0.1 0.26 11.4 0.1 1.7 1 0 0 1 1 1 0 Crustacean cuticle protein repeat RVT_1 PF00078.27 PIK55321.1 - 2e-18 66.7 0.1 2.4e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK55322.1 - 2.8e-26 92.0 0.1 3.5e-26 91.7 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK55322.1 - 2.1e-05 24.2 0.3 5.8e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain ATG13 PF10033.9 PIK55322.1 - 0.042 13.5 0.1 0.054 13.2 0.1 1.1 1 0 0 1 1 1 0 Autophagy-related protein 13 Tcp11 PF05794.13 PIK55325.1 - 2e-97 327.1 3.9 2.4e-97 326.8 3.9 1.1 1 0 0 1 1 1 1 T-complex protein 11 DUF325 PF03804.13 PIK55325.1 - 0.044 13.8 0.0 0.18 11.9 0.0 2.1 1 0 0 1 1 1 0 Viral proteins of unknown function GKAP PF03359.13 PIK55325.1 - 1.7 8.1 8.5 8 5.9 2.2 2.2 2 0 0 2 2 2 0 Guanylate-kinase-associated protein (GKAP) protein zf-C3HC4_3 PF13920.6 PIK55326.1 - 1.4e-10 40.9 19.3 3.2e-10 39.7 19.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FERM_C PF09380.10 PIK55326.1 - 5.8e-08 33.0 0.1 1.8e-07 31.4 0.1 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK55326.1 - 1.2e-07 32.1 0.6 5.1e-07 30.1 0.6 2.0 1 1 0 1 1 1 1 FERM central domain FERM_N PF09379.10 PIK55326.1 - 3.3e-07 30.1 0.0 7.8e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain Prok-RING_4 PF14447.6 PIK55326.1 - 0.0012 18.7 17.5 0.0032 17.3 17.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK55326.1 - 7.1 6.7 20.4 24 5.0 20.4 2.0 1 0 0 1 1 1 0 zinc-RING finger domain LPD37 PF18853.1 PIK55328.1 - 0.09 12.3 1.1 6 6.3 0.0 2.5 2 0 0 2 2 2 0 Large polyvalent protein associated domain 37 Snf7 PF03357.21 PIK55329.1 - 1e-42 145.7 21.4 1e-42 145.7 21.4 1.6 2 0 0 2 2 2 1 Snf7 YlqD PF11068.8 PIK55329.1 - 0.059 13.8 15.4 0.079 13.3 5.8 2.3 1 1 1 2 2 2 0 YlqD protein PspA_IM30 PF04012.12 PIK55329.1 - 0.25 10.9 21.3 0.68 9.5 5.6 2.4 1 1 1 2 2 2 0 PspA/IM30 family Ribosomal_L1 PF00687.21 PIK55330.1 - 2.2e-45 154.9 2.6 2.6e-45 154.7 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Telomerase_RBD PF12009.8 PIK55330.1 - 0.11 12.5 0.5 0.71 10.0 0.3 2.1 1 1 1 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain RRP36 PF06102.12 PIK55331.1 - 9.5e-46 155.8 27.9 1.2e-45 155.5 27.9 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 DUF2721 PF11026.8 PIK55332.1 - 1.5 8.7 4.2 1.9 8.4 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) HbrB PF08539.11 PIK55333.1 - 5.2e-14 52.6 0.0 1.4e-12 48.0 0.0 2.3 1 1 1 2 2 2 2 HbrB-like Cullin PF00888.22 PIK55333.1 - 0.0058 15.3 0.0 0.0073 15.0 0.0 1.1 1 0 0 1 1 1 1 Cullin family DUF1361 PF07099.11 PIK55333.1 - 0.18 11.7 0.0 0.41 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1361) Mito_carr PF00153.27 PIK55334.1 - 5.6e-16 58.2 0.0 1.6e-07 31.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1896 PF08989.10 PIK55334.1 - 0.026 14.6 0.0 0.042 14.0 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1896) Lectin_C PF00059.21 PIK55335.1 - 1.4e-12 48.3 0.0 1.9e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK55336.1 - 2e-19 70.3 0.1 5.1e-19 69.0 0.1 1.6 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK55336.1 - 0.00012 21.7 0.3 0.00019 21.1 0.3 1.3 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK55337.1 - 1.1e-12 48.6 0.0 1.5e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK55337.1 - 0.99 9.0 3.9 0.22 11.2 0.6 1.6 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like FAD_binding_7 PF03441.14 PIK55338.1 - 2e-60 203.7 1.7 3.2e-60 203.1 1.7 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 PIK55338.1 - 8.5e-25 87.7 0.0 1.3e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase rve_3 PF13683.6 PIK55339.1 - 0.039 13.7 0.0 0.086 12.6 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Nucleos_tra2_C PF07662.13 PIK55340.1 - 1.7e-80 269.7 2.4 4.2e-80 268.5 2.4 1.7 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 PIK55340.1 - 1.7e-26 92.6 3.4 1.7e-26 92.6 3.4 1.9 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 PIK55340.1 - 9.8e-08 32.3 4.2 9.8e-08 32.3 4.2 2.3 2 0 0 2 2 2 1 Nucleoside recognition BNR_2 PF13088.6 PIK55341.1 - 6.2e-26 91.3 0.0 1.1e-25 90.5 0.0 1.3 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK55341.1 - 3e-06 26.4 6.8 0.18 11.9 0.4 4.5 5 0 0 5 5 5 3 BNR/Asp-box repeat BNR_3 PF13859.6 PIK55341.1 - 3.1e-05 23.4 0.0 5.9e-05 22.5 0.0 1.4 2 0 0 2 2 2 1 BNR repeat-like domain DUF4185 PF13810.6 PIK55341.1 - 0.039 13.2 0.1 0.74 9.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4185) LRR_11 PF18831.1 PIK55341.1 - 0.12 12.0 0.1 0.28 10.8 0.1 1.6 1 0 0 1 1 1 0 Leucine-rich repeat zf-C3HC4 PF00097.25 PIK55342.1 - 1.2e-09 37.9 7.6 1.2e-09 37.9 7.6 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK55342.1 - 3.1e-09 36.7 4.7 3.1e-09 36.7 4.7 3.7 4 2 1 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK55342.1 - 5.8e-09 35.6 7.7 5.8e-09 35.6 7.7 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK55342.1 - 2.9e-08 33.4 6.3 2.9e-08 33.4 6.3 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK55342.1 - 2e-06 28.0 8.1 2e-06 28.0 8.1 3.3 3 0 0 3 3 3 1 Ring finger domain zf-B_box PF00643.24 PIK55342.1 - 6.5e-06 26.2 22.3 0.00032 20.8 7.1 4.2 5 0 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK55342.1 - 1.5e-05 24.7 6.9 1.5e-05 24.7 6.9 3.4 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK55342.1 - 1.6e-05 24.8 5.8 1.6e-05 24.8 5.8 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK55342.1 - 0.00047 20.2 9.3 0.00047 20.2 9.3 3.9 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING DZR PF12773.7 PIK55342.1 - 3.8 7.6 30.5 1 9.4 3.4 4.2 3 2 1 4 4 4 0 Double zinc ribbon Mitofilin PF09731.9 PIK55343.1 - 0.026 13.4 13.9 0.033 13.0 13.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein ThiC_Rad_SAM PF01964.18 PIK55343.1 - 0.036 12.9 0.6 0.05 12.4 0.6 1.2 1 0 0 1 1 1 0 Radical SAM ThiC family Glyco_hydro_53 PF07745.13 PIK55343.1 - 0.086 11.8 1.7 0.14 11.1 1.7 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 DUF3135 PF11333.8 PIK55343.1 - 0.17 12.1 1.8 6.9 7.0 0.6 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3135) zf-C3HC4 PF00097.25 PIK55344.1 - 2.1e-10 40.3 9.4 2.1e-10 40.3 9.4 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK55344.1 - 2.9e-10 40.0 6.9 9.5e-10 38.3 6.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK55344.1 - 6.1e-08 32.4 10.7 6.1e-08 32.4 10.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK55344.1 - 6.6e-08 32.8 8.4 6.6e-08 32.8 8.4 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK55344.1 - 9.2e-08 31.8 7.7 9.2e-08 31.8 7.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK55344.1 - 5.7e-06 26.4 9.0 5.7e-06 26.4 9.0 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK55344.1 - 6.9e-06 25.9 8.7 6.9e-06 25.9 8.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK55344.1 - 4.2e-05 23.3 8.6 4.2e-05 23.3 8.6 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-B_box PF00643.24 PIK55344.1 - 0.00061 19.9 13.0 0.00061 19.9 13.0 3.2 3 0 0 3 3 3 1 B-box zinc finger zf-RING_4 PF14570.6 PIK55344.1 - 0.0071 16.1 7.0 0.0071 16.1 7.0 2.2 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain Rad33 PF08730.10 PIK55344.1 - 0.035 14.1 0.0 0.099 12.6 0.0 1.7 1 0 0 1 1 1 0 Rad33 DWNN PF08783.11 PIK55344.1 - 0.57 10.5 4.4 0.34 11.2 0.2 2.5 2 0 0 2 2 2 0 DWNN domain zf-RING_11 PF17123.5 PIK55344.1 - 3.4 7.5 12.8 0.038 13.7 4.1 2.4 2 0 0 2 2 2 0 RING-like zinc finger fn3 PF00041.21 PIK55345.1 - 2.9e-19 69.2 4.9 1.1e-09 38.5 0.0 4.5 3 1 1 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK55345.1 - 0.0052 17.3 0.5 4.4 7.9 0.0 3.5 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain GPI-anchored PF10342.9 PIK55345.1 - 0.049 14.4 0.2 0.44 11.3 0.1 2.7 2 1 1 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glycos_transf_3 PF00591.21 PIK55346.1 - 3e-30 105.7 0.5 3.8e-30 105.3 0.5 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain PYNP_C PF07831.13 PIK55346.1 - 3.4e-11 42.6 0.1 6.9e-11 41.6 0.1 1.5 1 0 0 1 1 1 1 Pyrimidine nucleoside phosphorylase C-terminal domain adh_short PF00106.25 PIK55349.1 - 3.5e-06 26.6 0.1 9.4e-06 25.2 0.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK55349.1 - 0.00089 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CDC45 PF02724.14 PIK55349.1 - 3.1 6.0 17.5 2.1 6.5 16.1 1.4 2 0 0 2 2 2 0 CDC45-like protein DUF2151 PF10221.9 PIK55349.1 - 7.7 5.0 9.7 9.7 4.6 9.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF2201_N PF13203.6 PIK55349.1 - 9.4 5.7 11.6 12 5.3 11.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Di19_C PF14571.6 PIK55350.1 - 0.22 12.1 0.3 0.22 12.1 0.3 3.6 2 1 1 3 3 3 0 Stress-induced protein Di19, C-terminal NUC129 PF08157.11 PIK55351.1 - 0.019 15.3 4.9 0.028 14.7 0.0 3.2 2 1 1 3 3 3 0 NUC129 domain FAM60A PF15396.6 PIK55351.1 - 1.3 8.9 7.8 2.3 8.1 7.8 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Ig_3 PF13927.6 PIK55353.1 - 6.9e-05 23.4 0.3 0.16 12.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK55353.1 - 0.00016 21.7 0.0 0.18 11.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK55353.1 - 0.00058 20.0 0.5 0.31 11.3 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK55353.1 - 0.03 14.7 0.1 0.64 10.4 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK55353.1 - 0.094 12.9 0.3 0.48 10.6 0.0 2.3 2 1 0 2 2 2 0 Immunoglobulin V-set domain Sulfotransfer_1 PF00685.27 PIK55354.1 - 4.4e-36 124.7 0.2 4.9e-36 124.6 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK55355.1 - 3.8e-66 223.3 1.2 4.7e-66 223.0 1.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK55355.1 - 3.1e-10 40.8 0.0 7.6e-06 26.5 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family RVT_1 PF00078.27 PIK55356.1 - 5.5e-10 39.1 0.0 8.9e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHH_1 PF01402.21 PIK55356.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Acatn PF13000.7 PIK55357.1 - 1.4e-77 261.5 11.0 2.8e-35 121.8 0.2 3.0 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 Vma12 PF11712.8 PIK55357.1 - 0.24 11.5 1.4 0.54 10.3 0.2 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase TPR_12 PF13424.6 PIK55358.1 - 1.6e-14 53.9 2.6 5.3e-05 23.4 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat zf-MYND PF01753.18 PIK55358.1 - 3.9e-09 36.5 7.1 7e-09 35.6 7.1 1.5 1 0 0 1 1 1 1 MYND finger TPR_2 PF07719.17 PIK55358.1 - 1.4e-07 31.0 2.0 0.076 13.2 0.2 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55358.1 - 2.1e-05 24.3 0.3 0.34 11.2 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK55358.1 - 2.6e-05 23.8 3.9 0.2 11.5 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.9 PIK55358.1 - 0.0024 17.6 0.3 0.3 10.8 0.0 2.3 2 0 0 2 2 2 1 26S proteasome subunit RPN7 zf-Mss51 PF13824.6 PIK55358.1 - 0.03 14.4 1.2 0.09 12.9 1.2 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TPR_6 PF13174.6 PIK55358.1 - 0.032 14.9 2.4 32 5.4 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK55358.1 - 0.19 11.9 2.1 21 5.4 0.0 3.6 5 0 0 5 5 4 0 Tetratricopeptide repeat zf-HIT PF04438.16 PIK55358.1 - 0.57 10.1 5.3 0.97 9.4 5.3 1.3 1 0 0 1 1 1 0 HIT zinc finger KRAB PF01352.27 PIK55358.1 - 1 9.1 2.5 2.1 8.0 0.1 2.6 3 0 0 3 3 3 0 KRAB box TPR_4 PF07721.14 PIK55358.1 - 3.6 8.5 5.8 1 10.2 0.1 3.1 4 0 0 4 4 2 0 Tetratricopeptide repeat Sulfatase PF00884.23 PIK55359.1 - 2.1e-44 152.2 0.0 2.9e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 PIK55359.1 - 0.023 13.7 0.0 0.085 11.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) Sulfatase_C PF14707.6 PIK55359.1 - 0.087 13.6 0.0 0.19 12.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase FtsJ PF01728.19 PIK55360.1 - 9.9e-53 178.9 0.0 1.5e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Sec62 PF03839.16 PIK55361.1 - 5.8e-64 215.6 0.0 5.8e-64 215.6 0.0 2.6 2 1 1 3 3 3 1 Translocation protein Sec62 Zip PF02535.22 PIK55361.1 - 0.0047 16.2 2.2 1.3 8.2 5.7 2.2 2 0 0 2 2 2 1 ZIP Zinc transporter Dsh_C PF12316.8 PIK55361.1 - 0.095 13.1 10.8 1.2 9.6 0.5 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal CDC45 PF02724.14 PIK55361.1 - 0.23 9.7 23.7 0.27 9.5 9.6 2.2 2 0 0 2 2 2 0 CDC45-like protein Presenilin PF01080.17 PIK55361.1 - 1.8 7.2 16.6 0.41 9.4 5.6 2.2 2 0 0 2 2 2 0 Presenilin LAP1C PF05609.12 PIK55361.1 - 7.8 5.5 15.7 7 5.6 6.3 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Glyco_hydro_31 PF01055.26 PIK55362.1 - 6.2e-64 216.8 0.7 1e-63 216.1 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 PIK55362.1 - 0.00024 21.4 3.8 0.0029 17.9 3.3 2.9 2 1 0 2 2 2 1 Galactose mutarotase-like F_actin_cap_B PF01115.17 PIK55363.1 - 1.5e-107 358.7 0.0 1.6e-107 358.5 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 PIK55363.1 - 0.16 11.4 0.1 1.3 8.4 0.1 2.4 1 1 0 1 1 1 0 F-actin capping protein alpha subunit DNA_ligase_A_M PF01068.21 PIK55364.1 - 3.6e-61 206.4 0.0 1.5e-60 204.4 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase domain LIG3_BRCT PF16759.5 PIK55364.1 - 4.9e-20 71.6 0.0 1.1e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain DNA_ligase_A_N PF04675.14 PIK55364.1 - 1.3e-17 64.7 0.4 2.7e-17 63.6 0.4 1.6 1 0 0 1 1 1 1 DNA ligase N terminus zf-CCHH PF10283.9 PIK55364.1 - 4.1e-11 42.6 3.8 9.2e-11 41.5 3.8 1.6 1 0 0 1 1 1 1 PBZ domain DNA_ligase_A_C PF04679.15 PIK55364.1 - 5.5e-08 33.3 0.0 1.7e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 PIK55364.1 - 7.4e-08 32.7 0.1 3.2e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 PIK55364.1 - 2.5e-07 31.2 0.1 4.5e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 PIK55364.1 - 0.0018 18.1 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Mu-like_Pro PF10123.9 PIK55364.1 - 0.048 13.2 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein zf-H2C2_2 PF13465.6 PIK55365.1 - 8.9e-51 168.2 152.9 8.6e-05 22.8 3.1 21.6 21 1 0 21 21 21 17 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55365.1 - 1.4e-32 110.3 170.9 0.0015 18.9 0.5 19.5 20 0 0 20 20 20 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55365.1 - 2.1e-32 109.0 157.6 0.0031 18.2 3.6 19.0 19 0 0 19 19 19 16 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK55365.1 - 4.3e-06 26.6 145.0 0.0058 16.6 1.0 18.2 19 0 0 19 19 19 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK55365.1 - 1.3e-05 25.3 109.8 0.099 13.0 6.1 16.8 17 0 0 17 17 17 8 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 PIK55365.1 - 0.0057 16.4 10.5 13 5.6 0.0 6.4 5 1 1 6 6 6 1 GAGA factor BolA PF01722.18 PIK55365.1 - 0.16 12.3 16.7 5.6 7.3 0.5 6.3 5 2 2 7 7 7 0 BolA-like protein GPS PF01825.21 PIK55366.1 - 4.6e-16 59.1 5.3 1.3e-15 57.6 5.3 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK55366.1 - 1.2e-14 54.2 21.0 1.2e-14 54.2 21.0 2.5 2 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) PBP_sp32 PF07222.12 PIK55367.1 - 5.6 6.3 6.6 11 5.4 6.6 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Fumerase PF05681.14 PIK55368.1 - 2.7e-87 292.7 0.0 3.4e-87 292.3 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 PIK55368.1 - 1.7e-71 239.8 0.0 2.9e-71 239.1 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus RCC1 PF00415.18 PIK55369.1 - 2.3e-45 153.0 16.2 9.7e-11 42.1 0.2 6.6 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK55369.1 - 8.9e-21 73.2 12.1 1.7e-07 30.9 0.2 6.2 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat SDA1 PF05285.12 PIK55369.1 - 0.02 14.3 11.7 0.03 13.8 11.7 1.2 1 0 0 1 1 1 0 SDA1 TFIIF_alpha PF05793.12 PIK55369.1 - 0.3 9.6 18.0 0.44 9.1 18.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 PIK55369.1 - 0.41 9.2 6.3 0.5 8.9 6.3 1.2 1 0 0 1 1 1 0 Macoilin family Smg8_Smg9 PF10220.9 PIK55369.1 - 0.57 8.4 7.7 0.73 8.1 7.7 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Apt1 PF10351.9 PIK55369.1 - 0.59 8.9 8.0 0.79 8.5 8.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mitofilin PF09731.9 PIK55369.1 - 0.79 8.5 14.2 1.2 7.9 14.2 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Nop14 PF04147.12 PIK55369.1 - 2.6 6.2 14.6 3.5 5.7 14.6 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 PIK55369.1 - 4.2 6.1 7.5 6.7 5.4 7.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GREB1 PF15782.5 PIK55369.1 - 4.2 4.4 7.5 5.5 4.0 7.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Sigma70_ner PF04546.13 PIK55369.1 - 6.7 6.5 11.7 0.22 11.4 1.6 2.1 1 1 1 2 2 2 0 Sigma-70, non-essential region C1q PF00386.21 PIK55370.1 - 0.0028 17.9 0.0 1.5 9.0 0.0 2.2 2 0 0 2 2 2 2 C1q domain TERT_thumb PF17984.1 PIK55370.1 - 0.041 13.8 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Telomerase reverse transcriptase thumb DNA binding domain Aldedh PF00171.22 PIK55371.1 - 3.2e-21 75.4 0.0 3.6e-21 75.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Acyl_transf_3 PF01757.22 PIK55372.1 - 0.00075 18.7 3.4 0.00081 18.6 3.4 1.0 1 0 0 1 1 1 1 Acyltransferase family SpoU_methylas_C PF12105.8 PIK55372.1 - 0.18 11.5 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal Acyl_transf_3 PF01757.22 PIK55373.1 - 3.6e-07 29.6 22.0 0.00022 20.4 6.5 3.1 2 1 1 3 3 3 3 Acyltransferase family Acyl_transf_3 PF01757.22 PIK55374.1 - 4.7e-19 68.6 45.2 4.7e-19 68.6 45.2 1.5 2 0 0 2 2 2 1 Acyltransferase family Zip PF02535.22 PIK55374.1 - 0.0074 15.5 0.9 0.26 10.5 0.0 2.4 2 0 0 2 2 2 2 ZIP Zinc transporter Enolase_C PF00113.22 PIK55375.1 - 1.6e-93 313.2 0.1 1.7e-81 273.7 0.0 2.0 2 0 0 2 2 2 2 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 PIK55375.1 - 1.6e-05 24.6 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 PIK55375.1 - 5e-05 22.6 0.4 7.8e-05 22.0 0.4 1.2 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus PaRep2a PF07903.11 PIK55375.1 - 0.097 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 PaRep2a protein Enolase_N PF03952.16 PIK55376.1 - 7.6e-38 129.7 0.1 8.9e-38 129.4 0.1 1.1 1 0 0 1 1 1 1 Enolase, N-terminal domain PEX11 PF05648.14 PIK55377.1 - 1.8e-25 89.7 1.1 2e-25 89.5 1.1 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) GLTP PF08718.11 PIK55377.1 - 0.0054 17.0 0.3 0.038 14.3 0.0 2.1 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) Peptidase_M8 PF01457.16 PIK55378.1 - 5.6e-62 210.1 13.5 1.2e-61 209.1 10.6 2.8 2 2 1 3 3 3 1 Leishmanolysin WAP PF00095.21 PIK55378.1 - 2.5e-09 37.4 15.9 2.5e-09 37.4 15.9 3.6 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' NOG1 PF06858.14 PIK55379.1 - 1.7e-25 88.6 0.1 3.5e-25 87.6 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 PIK55379.1 - 4.9e-17 61.7 1.8 4.9e-17 61.7 1.8 2.0 2 0 0 2 2 2 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 PIK55379.1 - 0.0014 18.7 0.0 0.0052 16.9 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 PIK55379.1 - 0.037 14.0 0.5 0.5 10.4 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain SurA_N PF09312.11 PIK55379.1 - 0.04 14.0 0.5 0.093 12.8 0.5 1.6 1 0 0 1 1 1 0 SurA N-terminal domain NOG1_N PF17835.1 PIK55380.1 - 3.2e-52 176.7 1.7 4e-52 176.4 1.7 1.1 1 0 0 1 1 1 1 NOG1 N-terminal helical domain MMR_HSR1 PF01926.23 PIK55380.1 - 0.0034 17.5 0.1 0.0084 16.2 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase NEL PF14496.6 PIK55380.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting 7tm_1 PF00001.21 PIK55381.1 - 9.4e-42 143.1 24.2 1.4e-41 142.6 24.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55381.1 - 1.8e-06 27.8 18.6 1.8e-06 27.8 18.6 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55381.1 - 3.3e-05 23.4 23.6 4.3e-05 23.0 23.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK55381.1 - 0.00071 19.0 22.0 0.17 11.1 22.0 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF996 PF06195.13 PIK55381.1 - 3.2 8.0 15.1 0.38 11.0 3.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF996) Somatomedin_B PF01033.17 PIK55382.1 - 0.00028 21.2 9.9 0.0015 18.9 9.9 2.4 1 0 0 1 1 1 1 Somatomedin B domain Asp_protease_2 PF13650.6 PIK55383.1 - 3e-06 27.8 0.2 1.2e-05 25.9 0.0 2.1 3 0 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK55383.1 - 1.2e-05 25.8 0.2 4.4e-05 24.0 0.1 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease DUF1759 PF03564.15 PIK55383.1 - 0.00028 20.8 0.0 0.00082 19.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 PIK55383.1 - 0.0007 19.4 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Defensin_1 PF00323.19 PIK55384.1 - 2.1 9.0 7.1 0.17 12.4 1.5 2.1 2 0 0 2 2 2 0 Mammalian defensin zf-Di19 PF05605.12 PIK55385.1 - 0.0041 17.4 10.0 0.012 15.9 0.4 3.6 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 PIK55385.1 - 0.25 11.8 0.3 0.25 11.8 0.3 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-tcix PF14952.6 PIK55385.1 - 0.52 10.0 10.5 1.4 8.6 3.3 2.7 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.6 PIK55385.1 - 0.64 9.5 5.9 11 5.6 0.6 2.8 2 0 0 2 2 2 0 zinc-ribbon domain NPL PF17800.1 PIK55386.1 - 1.5e-13 51.2 0.0 1.9e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-H2C2_2 PF13465.6 PIK55387.1 - 7e-11 42.0 33.4 3.6e-06 27.2 2.0 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK55387.1 - 1.1e-07 32.0 34.3 0.042 14.7 0.5 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK55387.1 - 7.1e-05 23.0 36.1 0.0014 19.0 0.9 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf_C2H2_6 PF18450.1 PIK55387.1 - 0.00034 20.2 2.6 0.00034 20.2 2.6 2.7 1 1 1 2 2 2 1 Zinc Finger domain Ribonuclease_T2 PF00445.18 PIK55388.1 - 5.8e-32 111.4 4.8 8.6e-32 110.8 4.8 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Lung_7-TM_R PF06814.13 PIK55389.1 - 6.5e-33 114.2 5.3 7.6e-33 114.0 5.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 PIK55389.1 - 3.1e-05 23.5 6.5 3.9e-05 23.2 6.5 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain CDKN3 PF05706.12 PIK55390.1 - 2.6e-53 180.1 0.0 5.3e-53 179.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 PIK55390.1 - 0.00081 19.2 0.2 0.0025 17.6 0.0 2.0 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK55390.1 - 0.0039 16.8 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK55390.1 - 0.009 16.0 0.3 0.033 14.2 0.3 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK55390.1 - 0.021 15.0 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate HAD_2 PF13419.6 PIK55391.1 - 2.2e-22 80.0 0.0 2.9e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK55391.1 - 7.8e-13 48.3 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 PIK55391.1 - 1.2e-12 48.5 0.0 1.6e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Peptidase_M49 PF03571.15 PIK55392.1 - 6.3e-204 678.4 0.4 4.4e-114 381.8 0.2 2.1 1 1 1 2 2 2 2 Peptidase family M49 TRCF PF03461.15 PIK55392.1 - 0.082 13.3 0.0 24 5.4 0.0 3.4 3 0 0 3 3 3 0 TRCF domain Acetyltransf_1 PF00583.25 PIK55393.1 - 1.4e-08 34.9 0.0 2.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK55393.1 - 3.2e-08 33.6 0.0 4.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK55393.1 - 2.3e-06 27.9 0.0 2.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK55393.1 - 3.3e-06 27.0 0.0 4.4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 PIK55393.1 - 0.0015 18.6 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DRY_EERY PF09750.9 PIK55394.1 - 3.7e-43 147.0 0.2 3.7e-43 147.0 0.2 2.4 2 1 0 2 2 2 1 Alternative splicing regulator SIX1_SD PF16878.5 PIK55397.1 - 8.8e-43 145.4 3.6 3.3e-42 143.5 0.5 2.2 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 PIK55397.1 - 1.4e-14 53.7 2.0 3.2e-14 52.5 2.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK55397.1 - 2.5e-10 40.1 1.5 4.8e-10 39.2 1.5 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 PIK55397.1 - 0.0079 15.6 0.1 0.018 14.5 0.1 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 PIK55397.1 - 0.037 13.9 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 5_3_exonuc_N PF02739.16 PIK55397.1 - 0.092 12.6 0.1 0.22 11.4 0.1 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HTH_3 PF01381.22 PIK55397.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix SIX1_SD PF16878.5 PIK55398.1 - 4e-50 169.0 0.8 7.5e-50 168.1 0.2 1.7 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 PIK55398.1 - 4.9e-15 55.1 0.8 3e-14 52.6 0.2 2.2 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 PIK55398.1 - 6.7e-13 48.3 0.2 1.6e-12 47.1 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 PIK55398.1 - 0.012 15.7 0.0 0.07 13.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix Homez PF11569.8 PIK55398.1 - 0.019 14.5 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Phage_mat-A PF03863.13 PIK55398.1 - 0.026 13.4 0.0 0.037 12.9 0.0 1.1 1 0 0 1 1 1 0 Phage maturation protein DUF1456 PF07308.13 PIK55398.1 - 0.076 13.4 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) HTH_26 PF13443.6 PIK55398.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 PIK55398.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT SIX1_SD PF16878.5 PIK55399.1 - 1.2e-48 164.2 0.2 1.2e-47 161.0 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 PIK55399.1 - 1.1e-12 47.6 3.1 1.7e-12 47.0 0.9 2.3 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 PIK55399.1 - 2.5e-10 40.1 1.2 5.8e-10 38.9 1.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 PIK55399.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Ribonuclease_3 PF00636.26 PIK55400.1 - 2.6e-51 172.7 0.0 4.4e-24 85.1 0.0 2.8 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 PIK55400.1 - 1.7e-26 92.9 1.6 1.4e-17 64.1 0.4 3.1 2 1 0 2 2 2 2 Ribonuclease-III-like PAZ PF02170.22 PIK55401.1 - 6.5e-32 110.2 0.2 1.2e-31 109.4 0.2 1.4 1 0 0 1 1 1 1 PAZ domain Dicer_dimer PF03368.14 PIK55401.1 - 9.4e-29 99.4 0.0 2.5e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.31 PIK55401.1 - 6.2e-06 26.5 0.0 1.4e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK55401.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PAS_11 PF14598.6 PIK55402.1 - 0.013 15.7 0.2 1.1 9.4 0.1 2.0 1 1 1 2 2 2 0 PAS domain Metallophos PF00149.28 PIK55403.1 - 5.8e-39 134.7 0.1 7.1e-39 134.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 PIK55403.1 - 2.3e-16 60.0 0.6 4.6e-16 59.0 0.4 1.6 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain TMEM154 PF15102.6 PIK55404.1 - 3.9e-09 36.6 0.4 8.9e-09 35.4 0.4 1.6 1 0 0 1 1 1 1 TMEM154 protein family C2-set_2 PF08205.12 PIK55404.1 - 0.00093 19.2 0.1 0.0034 17.4 0.1 2.0 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK55404.1 - 0.0014 18.8 0.1 0.68 10.1 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin V-set domain DUF4834 PF16118.5 PIK55404.1 - 0.019 15.9 0.0 0.047 14.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) C1-set PF07654.15 PIK55404.1 - 0.025 15.0 0.1 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Insulin_TMD PF17870.1 PIK55404.1 - 0.088 12.9 2.2 0.23 11.6 2.2 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF3377 PF11857.8 PIK55404.1 - 0.13 12.2 1.2 0.33 10.9 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Ephrin_rec_like PF07699.13 PIK55405.1 - 0.00019 21.1 2.4 0.00039 20.1 2.4 1.5 1 0 0 1 1 1 1 Putative ephrin-receptor like NCD3G PF07562.14 PIK55405.1 - 0.017 15.0 2.3 0.036 14.0 2.3 1.5 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Staph_haemo PF05480.11 PIK55405.1 - 0.19 11.5 0.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Staphylococcus haemolytic protein LRR_8 PF13855.6 PIK55406.1 - 0.0023 17.6 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 PIK55406.1 - 0.018 15.5 0.1 0.15 12.7 0.0 2.5 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 PIK55406.1 - 0.062 13.7 0.0 0.2 12.1 0.0 1.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Prok-RING_1 PF14446.6 PIK55407.1 - 1.6 8.7 4.5 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 RVT_1 PF00078.27 PIK55408.1 - 0.038 13.5 0.1 0.047 13.2 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF608 PF04685.13 PIK55408.1 - 0.057 12.6 0.1 0.079 12.1 0.1 1.1 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region LRR_8 PF13855.6 PIK55409.1 - 3.1e-13 49.2 17.0 9.5e-07 28.5 0.8 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 PIK55409.1 - 2e-05 24.5 6.1 2.5e-05 24.2 1.6 2.3 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ephrin_rec_like PF07699.13 PIK55409.1 - 0.0003 20.5 29.2 0.00046 19.9 6.1 5.0 2 1 2 4 4 4 3 Putative ephrin-receptor like Adipogenin PF15202.6 PIK55409.1 - 0.012 15.6 1.0 0.14 12.2 0.2 2.7 2 0 0 2 2 2 0 Adipogenin NCD3G PF07562.14 PIK55409.1 - 0.013 15.5 21.1 0.075 13.0 0.3 4.5 3 1 1 4 4 4 0 Nine Cysteines Domain of family 3 GPCR LRR_9 PF14580.6 PIK55409.1 - 0.048 13.1 3.0 0.57 9.7 1.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeat LRR_4 PF12799.7 PIK55409.1 - 0.057 13.9 19.3 1.7 9.2 1.7 4.7 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 PIK55410.1 - 0.00025 21.4 0.0 0.00067 20.0 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4769 PF15992.5 PIK55410.1 - 0.068 13.0 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) LRR_8 PF13855.6 PIK55411.1 - 2.6e-39 132.8 14.3 3.5e-10 39.5 0.1 5.6 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK55411.1 - 5.4e-32 110.4 29.0 6.3e-16 58.5 4.2 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK55411.1 - 5.1e-19 68.0 19.1 0.0032 17.8 0.0 6.7 1 1 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK55411.1 - 2.6e-11 43.3 7.5 0.0069 15.9 0.1 3.7 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK55411.1 - 4.3e-06 26.5 19.5 1.1 10.1 0.0 8.8 10 1 0 10 10 10 2 Leucine Rich Repeat Sec20 PF03908.13 PIK55411.1 - 0.1 12.6 0.5 8.3 6.4 0.1 3.4 1 1 2 3 3 3 0 Sec20 DUF4466 PF14725.6 PIK55411.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4466) Aurora-A_bind PF09041.10 PIK55411.1 - 0.15 12.2 3.3 12 6.1 0.0 4.0 3 1 1 4 4 4 0 Aurora-A binding Antig_Caf1 PF09255.10 PIK55412.1 - 0.0065 16.6 0.3 0.01 15.9 0.3 1.3 1 0 0 1 1 1 1 Caf1 Capsule antigen SprB PF13573.6 PIK55412.1 - 1.7 8.4 7.2 0.23 11.2 2.5 2.1 2 0 0 2 2 2 0 SprB repeat LRR_9 PF14580.6 PIK55413.1 - 6.5e-19 68.1 5.8 3e-18 65.9 4.1 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 PIK55413.1 - 2.1e-10 40.2 13.4 5.2e-07 29.3 4.0 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK55413.1 - 5.7e-09 36.1 16.9 3.5e-05 24.1 2.0 3.3 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK55413.1 - 0.087 13.4 5.4 4.3 8.3 0.0 4.2 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_3 PF07725.12 PIK55413.1 - 0.13 12.2 1.0 5.1 7.1 0.2 2.9 2 0 0 2 2 2 0 Leucine Rich Repeat Forkhead PF00250.18 PIK55414.1 - 2.6e-12 46.8 0.0 6.4e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain V-set PF07686.17 PIK55415.1 - 1.4e-10 41.3 0.2 3.2e-10 40.2 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK55415.1 - 5.2e-06 27.0 0.1 2.4e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK55415.1 - 0.00059 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK55415.1 - 0.0028 17.7 0.0 0.0066 16.5 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK55415.1 - 0.0034 17.7 3.3 0.017 15.4 0.6 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 PIK55415.1 - 0.0048 16.4 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK55416.1 - 2e-11 44.0 2.3 7.2e-06 26.1 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK55416.1 - 2.8e-09 37.4 0.6 0.036 14.7 0.0 4.1 2 1 2 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK55416.1 - 5.3e-07 29.7 1.0 0.68 10.1 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain DUF4577 PF15145.6 PIK55416.1 - 0.0053 16.8 0.4 0.037 14.1 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4577) TMEM154 PF15102.6 PIK55416.1 - 0.006 16.5 1.3 0.0096 15.8 0.0 2.1 2 0 0 2 2 2 1 TMEM154 protein family T2SSF PF00482.23 PIK55416.1 - 0.12 12.3 2.7 1.5 8.8 1.1 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F EphA2_TM PF14575.6 PIK55416.1 - 0.13 13.2 0.0 0.4 11.6 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 PIK55416.1 - 0.65 10.3 3.4 0.54 10.6 0.2 2.3 2 0 0 2 2 2 0 Orf78 (ac78) UPF0242 PF06785.11 PIK55416.1 - 3.9 7.5 11.4 0.5 10.4 5.7 2.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus C2-set_2 PF08205.12 PIK55417.1 - 2.7e-10 40.2 0.2 3.8e-10 39.7 0.2 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK55417.1 - 1.2e-05 25.5 0.1 2.4e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK55417.1 - 5.1e-05 23.8 0.0 9.4e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK55417.1 - 0.00074 19.6 0.2 0.0012 18.9 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain NACHT PF05729.12 PIK55418.1 - 2.3e-16 60.2 0.0 4.4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 PIK55418.1 - 4.3e-08 32.6 0.0 1e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK55418.1 - 0.00039 20.7 0.0 0.0068 16.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain GSG-1 PF07803.11 PIK55418.1 - 0.0079 16.1 0.2 0.022 14.6 0.0 1.8 2 0 0 2 2 2 1 GSG1-like protein GPI2 PF06432.11 PIK55418.1 - 0.012 15.1 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_16 PF13191.6 PIK55418.1 - 0.063 13.7 0.0 0.17 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.18 PIK55418.1 - 0.086 12.6 0.1 23 4.7 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase V-set PF07686.17 PIK55419.1 - 5.5e-07 29.7 0.1 0.00038 20.6 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK55419.1 - 0.00027 21.5 0.3 0.26 11.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK55419.1 - 0.0006 19.9 1.0 0.52 10.5 0.0 3.6 4 1 0 4 4 4 1 Immunoglobulin domain DUF3694 PF12473.8 PIK55419.1 - 0.072 13.7 0.1 1 10.0 0.0 2.2 2 0 0 2 2 2 0 Kinesin protein RVT_1 PF00078.27 PIK55421.1 - 1.4e-34 119.6 0.0 1.8e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Collagen PF01391.18 PIK55422.1 - 2.5e-14 52.8 53.0 9.3e-09 34.9 25.4 3.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.6 PIK55422.1 - 0.027 14.6 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 PIK55422.1 - 0.093 13.3 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain HECT PF00632.25 PIK55423.1 - 6.2e-13 48.9 0.0 1.6e-06 27.8 0.0 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Collagen PF01391.18 PIK55424.1 - 3.1e-74 244.6 249.3 3.2e-10 39.6 19.2 11.3 5 3 6 11 11 11 11 Collagen triple helix repeat (20 copies) zf-B_box PF00643.24 PIK55425.1 - 3.9e-08 33.3 30.0 2.1e-07 30.9 7.4 3.5 3 0 0 3 3 3 2 B-box zinc finger DUF2524 PF10732.9 PIK55425.1 - 0.0075 16.5 2.2 0.023 15.0 2.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2524) Apolipoprotein PF01442.18 PIK55425.1 - 0.012 15.6 3.5 0.025 14.4 3.5 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2229 PF09989.9 PIK55425.1 - 0.051 13.2 1.6 0.11 12.1 1.6 1.5 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) TMPIT PF07851.13 PIK55425.1 - 0.25 10.6 5.4 0.44 9.8 5.4 1.4 1 0 0 1 1 1 0 TMPIT-like protein Siva PF05458.12 PIK55425.1 - 3.8 7.2 13.7 13 5.4 6.6 2.6 1 1 0 2 2 2 0 Cd27 binding protein (Siva) zf-Sec23_Sec24 PF04810.15 PIK55425.1 - 7.2 6.8 9.8 14 5.8 0.6 4.0 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger KELK PF15796.5 PIK55425.1 - 9 6.8 16.6 0.46 11.0 1.1 3.4 2 1 2 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Phosphodiest PF01663.22 PIK55426.1 - 4.1e-48 164.8 0.3 6e-48 164.2 0.3 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Endonuclease_NS PF01223.23 PIK55426.1 - 0.00029 20.7 0.0 0.003 17.4 0.0 2.2 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease HMG_box PF00505.19 PIK55427.1 - 8.4e-11 42.1 2.1 8.4e-11 42.1 2.1 3.0 2 0 0 2 2 2 1 HMG (high mobility group) box Joubert PF15392.6 PIK55428.1 - 3.3e-08 33.6 16.3 3.3e-08 33.6 16.3 3.7 2 2 1 3 3 3 1 Joubert syndrome-associated Spectrin PF00435.21 PIK55428.1 - 0.00095 19.6 3.1 0.0063 17.0 0.4 3.1 2 0 0 2 2 2 1 Spectrin repeat Adhes-Ig_like PF09085.10 PIK55429.1 - 0.064 13.4 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like FATC PF02260.20 PIK55430.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 FATC domain RT_RNaseH_2 PF17919.1 PIK55432.1 - 7.8e-35 118.9 0.0 1.1e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55432.1 - 2.4e-28 98.5 0.0 3.5e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Laminin_EGF PF00053.24 PIK55433.1 - 9.2e-11 41.7 71.3 0.003 17.7 16.3 4.6 2 2 2 4 4 4 4 Laminin EGF domain hEGF PF12661.7 PIK55433.1 - 2.3e-05 24.8 19.1 9.3e-05 22.9 5.3 7.2 6 2 1 7 7 7 4 Human growth factor-like EGF EGF PF00008.27 PIK55433.1 - 0.012 16.0 79.2 0.056 13.8 11.8 6.0 5 2 1 6 6 6 0 EGF-like domain EGF_2 PF07974.13 PIK55433.1 - 0.33 11.4 84.6 0.8 10.1 18.4 7.3 4 4 0 4 4 4 0 EGF-like domain Laminin_EGF PF00053.24 PIK55434.1 - 3e-15 56.1 64.1 1.4e-06 28.3 13.2 4.5 3 1 1 4 4 4 4 Laminin EGF domain EGF_2 PF07974.13 PIK55434.1 - 8e-08 32.5 81.7 0.00076 19.8 2.7 8.3 7 2 1 8 8 8 5 EGF-like domain TMEM154 PF15102.6 PIK55434.1 - 0.0021 17.9 0.0 0.0031 17.4 0.0 1.1 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 PIK55434.1 - 0.0031 16.9 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) hEGF PF12661.7 PIK55434.1 - 0.0037 17.9 3.2 0.0037 17.9 3.2 7.8 6 2 1 7 7 7 3 Human growth factor-like EGF EGF PF00008.27 PIK55434.1 - 0.0094 16.2 19.8 0.031 14.6 10.2 7.5 8 0 0 8 8 8 3 EGF-like domain DSL PF01414.19 PIK55434.1 - 2.4 8.5 66.9 0.15 12.4 12.1 4.3 4 0 0 4 4 4 0 Delta serrate ligand Laminin_EGF PF00053.24 PIK55435.1 - 2.7e-26 91.5 192.9 0.0021 18.2 7.7 11.3 3 2 8 11 11 11 10 Laminin EGF domain hEGF PF12661.7 PIK55435.1 - 2.1e-05 25.0 49.8 0.0035 17.9 6.1 16.1 14 3 2 16 16 16 8 Human growth factor-like EGF DSL PF01414.19 PIK55435.1 - 0.021 15.1 17.0 0.021 15.1 17.0 10.2 10 0 0 10 10 10 0 Delta serrate ligand EGF_2 PF07974.13 PIK55435.1 - 0.023 15.0 17.6 0.023 15.0 17.6 18.8 12 10 2 14 14 14 0 EGF-like domain RIC3 PF15361.6 PIK55436.1 - 0.0032 17.9 0.0 0.0049 17.3 0.0 1.4 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 LMBR1 PF04791.16 PIK55436.1 - 0.083 11.8 0.3 0.089 11.7 0.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein SCAN PF02023.17 PIK55437.1 - 1.2e-12 47.4 0.0 2.9e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK55437.1 - 0.0065 16.7 0.8 1.4 9.2 0.2 2.7 1 1 1 2 2 2 2 Retrotransposon gag protein DUF4407 PF14362.6 PIK55437.1 - 0.034 13.5 5.1 0.042 13.2 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 PIK55437.1 - 6.8 4.9 10.0 9.8 4.3 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Integrase_H2C2 PF17921.1 PIK55438.1 - 5.3e-19 68.1 0.1 9.6e-19 67.3 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK55438.1 - 4.7e-17 62.3 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK55438.1 - 0.00011 22.4 0.4 0.00055 20.1 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK55438.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 PIK55439.1 - 2.1e-37 127.2 0.0 4.1e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55439.1 - 1.6e-35 121.6 0.0 3.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55439.1 - 2.5e-27 95.8 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TBCC PF07986.12 PIK55440.1 - 2.2e-38 130.7 7.3 5.1e-38 129.5 6.8 1.8 2 0 0 2 2 2 1 Tubulin binding cofactor C CAP_C PF08603.11 PIK55440.1 - 6.9e-05 22.5 0.5 0.00017 21.3 0.5 1.7 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal ATG101 PF07855.12 PIK55441.1 - 1.2e-40 139.0 0.1 1.7e-40 138.5 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 NACHT PF05729.12 PIK55442.1 - 3.6e-15 56.3 0.0 9.4e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK55442.1 - 0.00013 21.6 0.0 0.00044 19.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain SPARC_Ca_bdg PF10591.9 PIK55444.1 - 0.11 12.8 0.0 0.45 10.9 0.0 2.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NACHT PF05729.12 PIK55445.1 - 9e-10 38.7 0.0 2.3e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK55445.1 - 0.038 13.6 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain TFIIE_beta PF02186.15 PIK55445.1 - 0.49 10.7 3.2 35 4.8 0.1 4.0 4 0 0 4 4 4 0 TFIIE beta subunit core domain DUF1759 PF03564.15 PIK55446.1 - 1e-07 32.0 0.0 1.7e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) CABIT PF12736.7 PIK55446.1 - 0.049 12.9 1.7 0.07 12.4 0.0 2.1 2 0 0 2 2 2 0 Cell-cycle sustaining, positive selection, DUF4841 PF16129.5 PIK55446.1 - 0.11 12.8 0.1 2.5 8.4 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4841) CUB PF00431.20 PIK55447.1 - 2.1e-10 40.9 0.0 3.2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 PIK55447.1 - 4.5e-06 26.8 12.0 4.5e-06 26.8 12.0 1.7 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Ras PF00071.22 PIK55448.1 - 1.1e-23 83.6 0.0 1.4e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK55448.1 - 9.9e-10 38.7 0.0 2.3e-09 37.5 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK55448.1 - 4.9e-05 22.9 0.0 6.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Pox_D2 PF04701.13 PIK55448.1 - 0.11 12.7 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Pox virus D2 protein Gtr1_RagA PF04670.12 PIK55448.1 - 0.12 11.7 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region WD40 PF00400.32 PIK55449.1 - 7.1e-17 61.5 10.7 0.00041 21.1 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55449.1 - 1.3e-08 35.0 0.0 0.00013 22.2 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK55449.1 - 6.1e-06 25.4 0.2 0.096 11.6 0.1 2.3 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Med16 PF11635.8 PIK55449.1 - 3e-05 22.2 0.3 4.9e-05 21.5 0.3 1.2 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40_like PF17005.5 PIK55449.1 - 0.074 12.4 0.0 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain OSCP PF00213.18 PIK55449.1 - 0.19 11.9 0.1 0.38 10.8 0.1 1.4 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit 7tm_1 PF00001.21 PIK55450.1 - 4.2e-41 141.0 16.7 7.1e-41 140.3 11.5 2.3 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK55450.1 - 6.8e-11 42.0 10.0 6.8e-11 42.0 10.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK55450.1 - 1.2e-07 31.7 14.9 1.9e-07 31.0 14.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK55450.1 - 2.8e-06 27.3 7.2 4e-06 26.8 7.2 1.2 1 0 0 1 1 1 1 Olfactory receptor UPF0697 PF15117.6 PIK55451.1 - 4.3e-21 74.8 0.3 4.9e-21 74.6 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0697 RloB PF13707.6 PIK55451.1 - 0.047 13.9 0.1 0.05 13.8 0.1 1.1 1 0 0 1 1 1 0 RloB-like protein RGS PF00615.19 PIK55452.1 - 5.3e-18 65.4 1.3 5.3e-18 65.4 1.3 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase PF00069.25 PIK55452.1 - 3.3e-15 56.2 0.2 5.8e-15 55.4 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55452.1 - 8e-06 25.3 0.2 1.1e-05 24.8 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2590 PF10761.9 PIK55452.1 - 0.033 14.3 0.0 0.059 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2590) DUF446 PF04287.12 PIK55452.1 - 0.088 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 tRNA pseudouridine synthase C EMC3_TMCO1 PF01956.16 PIK55452.1 - 0.14 11.9 0.2 0.23 11.2 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Pkinase PF00069.25 PIK55453.1 - 7.5e-28 97.6 0.0 1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55453.1 - 2.2e-12 46.8 0.0 3.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1858 PF08984.11 PIK55453.1 - 0.051 13.7 2.6 12 6.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1858) OLF PF02191.16 PIK55454.1 - 9.5e-54 182.6 0.3 1e-53 182.4 0.3 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain OLF PF02191.16 PIK55455.1 - 2.4e-07 30.6 0.0 3.4e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain SlyX PF04102.12 PIK55455.1 - 0.0016 19.0 5.0 0.064 13.9 0.2 3.3 2 1 1 3 3 3 1 SlyX Spc7 PF08317.11 PIK55455.1 - 0.024 13.5 2.9 0.048 12.6 2.9 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Gluconate_2-dh3 PF13618.6 PIK55455.1 - 0.034 14.4 0.0 0.042 14.1 0.0 1.3 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 Fib_alpha PF08702.10 PIK55455.1 - 0.053 13.7 3.9 0.78 9.9 0.6 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Rootletin PF15035.6 PIK55455.1 - 0.065 13.3 2.5 0.13 12.2 2.5 1.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion AAA_13 PF13166.6 PIK55455.1 - 0.074 11.7 0.7 0.092 11.4 0.7 1.1 1 0 0 1 1 1 0 AAA domain Jnk-SapK_ap_N PF09744.9 PIK55455.1 - 0.092 13.0 2.1 0.14 12.4 1.8 1.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Pox_A_type_inc PF04508.12 PIK55455.1 - 0.098 12.5 0.2 0.55 10.2 0.0 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat HMMR_N PF15905.5 PIK55455.1 - 0.16 11.4 2.3 0.24 10.8 2.3 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Med9 PF07544.13 PIK55455.1 - 0.18 11.9 2.0 1.1 9.4 0.1 2.7 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Noelin-1 PF12308.8 PIK55455.1 - 0.18 11.8 0.8 1 9.4 0.1 2.2 1 1 1 2 2 2 0 Neurogenesis glycoprotein Matrilin_ccoil PF10393.9 PIK55455.1 - 0.19 11.6 0.7 0.92 9.4 0.1 2.5 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Tropomyosin_1 PF12718.7 PIK55455.1 - 1.1 9.4 3.8 6.1 7.0 0.2 2.4 1 1 1 2 2 2 0 Tropomyosin like EF-hand_1 PF00036.32 PIK55456.1 - 1.5e-13 49.2 8.9 8e-08 31.3 1.4 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 PIK55456.1 - 1.3e-11 43.4 10.5 1.2e-07 31.0 0.9 3.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 PIK55456.1 - 6.1e-11 42.6 5.9 5.4e-06 26.8 0.5 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK55456.1 - 7.7e-07 28.9 6.5 0.00016 21.4 2.0 3.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK55456.1 - 3.2e-05 23.2 1.1 3.2e-05 23.2 1.1 2.7 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 PIK55456.1 - 0.0018 18.3 0.1 0.052 13.6 0.0 2.2 1 1 1 2 2 2 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.9 PIK55456.1 - 0.037 14.4 0.2 0.048 14.0 0.2 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK55456.1 - 0.06 13.3 0.3 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 PIK55456.1 - 0.1 12.9 0.1 7.6 6.9 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain Lung_7-TM_R PF06814.13 PIK55457.1 - 1.3e-09 37.8 19.4 2.5e-09 36.8 19.4 1.5 1 1 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 PIK55457.1 - 2.8e-08 33.5 19.0 4.3e-07 29.6 19.0 2.1 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 PIK55458.1 - 1.2e-08 34.5 11.5 1.2e-08 34.5 11.5 2.4 2 0 0 2 2 2 1 Lung seven transmembrane receptor Saf_2TM PF18303.1 PIK55458.1 - 1.8 8.1 6.5 2.5 7.7 1.5 2.7 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Phage_terminase PF10668.9 PIK55459.1 - 0.0028 17.6 2.2 0.014 15.4 0.1 3.3 3 0 0 3 3 3 1 Phage terminase small subunit Tropomyosin_1 PF12718.7 PIK55459.1 - 0.0074 16.4 15.6 0.0074 16.4 15.6 9.7 1 1 7 9 9 9 4 Tropomyosin like COMPASS-Shg1 PF05205.12 PIK55460.1 - 1e-24 87.1 0.1 1.5e-24 86.7 0.1 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 MarR_2 PF12802.7 PIK55460.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 MarR family DUF445 PF04286.12 PIK55460.1 - 0.093 12.5 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) CDPS PF16715.5 PIK55460.1 - 0.2 11.3 0.3 1.9 8.1 0.1 2.0 1 1 1 2 2 2 0 Cyclodipeptide synthase SUFU_C PF12470.8 PIK55464.1 - 2.5e-62 210.6 0.0 3.3e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain SUFU PF05076.13 PIK55464.1 - 3.9e-51 173.4 0.0 5.4e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) Actin PF00022.19 PIK55465.1 - 2.2e-130 434.9 0.0 1.3e-129 432.4 0.0 1.8 1 1 0 1 1 1 1 Actin Glyco_hydro_63 PF03200.16 PIK55466.1 - 7.5e-206 684.6 0.2 9.2e-206 684.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 PIK55466.1 - 4e-45 154.7 0.0 4e-45 154.7 0.0 2.5 3 0 0 3 3 3 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.14 PIK55466.1 - 1.6e-05 24.0 0.3 4.2e-05 22.7 0.2 1.7 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase NAM-associated PF14303.6 PIK55466.1 - 0.05 14.3 4.0 0.095 13.4 4.0 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF4614 PF15391.6 PIK55466.1 - 0.2 11.7 7.9 2.1 8.3 8.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 PIK55466.1 - 1.1 8.0 7.4 1.7 7.4 7.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 PIK55466.1 - 3.5 7.2 20.2 5.2 6.6 20.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ras PF00071.22 PIK55467.1 - 2.4e-13 50.0 0.0 8.4e-13 48.2 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK55467.1 - 8.7e-09 35.6 0.0 1.9e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 PIK55467.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Cir_N PF10197.9 PIK55467.1 - 0.018 15.2 0.1 0.032 14.4 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR BTB PF00651.31 PIK55468.1 - 7.9e-15 55.0 0.4 9e-07 29.1 0.1 2.3 2 0 0 2 2 2 2 BTB/POZ domain Ras PF00071.22 PIK55468.1 - 0.00024 20.7 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 Ras family BTB PF00651.31 PIK55469.1 - 4.7e-11 42.9 0.1 1.9e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Ribosomal_S18 PF01084.20 PIK55471.1 - 6.2e-17 61.5 0.0 1.1e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Peptidase_C48 PF02902.19 PIK55472.1 - 6.3e-11 42.5 1.1 8.8e-11 42.1 1.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DDE_Tnp_1_6 PF13751.6 PIK55472.1 - 0.11 12.8 2.7 0.22 11.8 2.7 1.4 1 0 0 1 1 1 0 Transposase DDE domain Cytochrom_C550 PF14495.6 PIK55472.1 - 0.11 12.2 0.3 0.22 11.2 0.3 1.5 1 0 0 1 1 1 0 Cytochrome c-550 domain PHD PF00628.29 PIK55472.1 - 0.51 10.3 6.3 1.1 9.2 6.3 1.6 1 0 0 1 1 1 0 PHD-finger GH3 PF03321.13 PIK55473.1 - 2.8e-121 406.0 0.0 3.3e-121 405.8 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter DUF842 PF05811.13 PIK55474.1 - 2.3e-43 147.0 11.6 2.6e-43 146.8 11.6 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) RVT_1 PF00078.27 PIK55475.1 - 0.015 14.8 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Homeodomain PF00046.29 PIK55476.1 - 1.8e-20 72.5 2.9 3.2e-20 71.7 2.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK55476.1 - 0.04 13.8 0.2 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Homeobox KN domain Homez PF11569.8 PIK55476.1 - 0.054 13.0 0.0 0.15 11.6 0.0 1.9 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SCHIP-1 PF10148.9 PIK55476.1 - 0.27 10.8 1.9 0.36 10.4 1.9 1.1 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 CCDC106 PF15794.5 PIK55476.1 - 0.49 10.1 5.8 0.83 9.3 5.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 WD40 PF00400.32 PIK55477.1 - 2.7e-20 72.3 7.8 1.1e-05 26.1 0.4 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55477.1 - 6.6e-09 36.0 0.0 0.35 11.2 0.0 4.0 2 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK55477.1 - 0.00017 21.5 0.2 0.029 14.2 0.1 2.5 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A MVP_shoulder PF11978.8 PIK55478.1 - 3.6e-45 152.8 0.3 7.7e-45 151.7 0.3 1.6 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.18 PIK55478.1 - 1.8e-43 146.5 0.0 6.8e-15 55.0 0.0 5.0 5 0 0 5 5 5 4 Major Vault Protein repeat domain Vault_3 PF17795.1 PIK55478.1 - 2.1e-36 123.7 0.2 1.2e-28 98.9 0.0 3.8 4 0 0 4 4 4 2 Major Vault Protein Repeat domain Vault_2 PF17794.1 PIK55478.1 - 2.2e-24 85.6 1.2 2.2e-14 53.6 0.3 2.8 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_4 PF17796.1 PIK55478.1 - 3.2e-22 78.4 0.1 1.5e-21 76.2 0.1 2.2 2 0 0 2 2 2 1 Major Vault Protein repeat domain Fumble PF03630.14 PIK55479.1 - 1.1e-107 360.0 0.0 1.3e-107 359.8 0.0 1.0 1 0 0 1 1 1 1 Fumble COX15-CtaA PF02628.15 PIK55480.1 - 6.7e-60 202.9 13.4 1.2e-40 139.6 2.9 2.9 1 1 2 3 3 3 3 Cytochrome oxidase assembly protein Abhydrolase_1 PF00561.20 PIK55481.1 - 3.1e-13 50.0 0.1 5.8e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK55481.1 - 1.7e-10 41.9 0.0 2.2e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK55481.1 - 0.00022 20.6 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 PIK55481.1 - 0.013 14.6 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_1 PF00561.20 PIK55482.1 - 1.8e-13 50.7 0.1 5.6e-13 49.1 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK55482.1 - 1.2e-06 29.3 0.0 1.5e-06 29.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK55482.1 - 0.0022 17.3 0.0 0.0028 16.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DHHC PF01529.20 PIK55483.1 - 1.1e-32 112.9 11.1 1.1e-32 112.9 11.1 2.9 2 2 0 2 2 2 1 DHHC palmitoyltransferase DUF1272 PF06906.11 PIK55483.1 - 0.095 12.8 5.1 0.24 11.5 5.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) SLBP_RNA_bind PF15247.6 PIK55484.1 - 3.7e-29 100.6 4.7 6e-29 100.0 4.7 1.3 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain M-inducer_phosp PF06617.13 PIK55485.1 - 2.6e-15 56.4 24.4 1.2e-13 51.0 24.4 2.1 1 1 0 1 1 1 1 M-phase inducer phosphatase Rhodanese PF00581.20 PIK55485.1 - 1.3e-11 44.9 0.0 2.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain PMSR PF01625.21 PIK55486.1 - 5.3e-22 78.7 0.5 6.8e-22 78.3 0.5 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Urotensin_II PF02083.15 PIK55486.1 - 3.2 7.6 6.2 16 5.5 0.6 2.5 2 0 0 2 2 2 0 Urotensin II CATSPERG PF15064.6 PIK55487.1 - 1.5e-54 185.2 0.0 2.1e-50 171.6 0.0 2.1 2 0 0 2 2 2 2 Cation channel sperm-associated protein subunit gamma Pentapeptide PF00805.22 PIK55488.1 - 3.3e-32 109.7 25.8 3.3e-10 39.4 4.2 4.8 3 1 1 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 PIK55488.1 - 8.9e-19 67.4 3.4 4.3e-10 39.6 0.2 3.0 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 PIK55488.1 - 3.2e-14 52.8 0.0 0.00013 22.1 0.0 3.8 3 0 0 3 3 3 3 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 PIK55488.1 - 9.4e-14 51.5 0.0 1.9e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain KHA PF11834.8 PIK55488.1 - 1.1e-09 38.2 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel BTB_3 PF16017.5 PIK55488.1 - 0.00019 21.5 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Requiem_N PF14051.6 PIK55488.1 - 0.025 14.8 0.3 0.077 13.2 0.2 1.9 2 0 0 2 2 2 0 N-terminal domain of DPF2/REQ. GCP_N_terminal PF17681.1 PIK55491.1 - 1.4e-44 153.0 0.4 2.9e-44 152.0 0.0 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 PIK55491.1 - 1.3e-35 123.4 10.7 2.7e-35 122.3 10.7 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF3709 PF12493.8 PIK55491.1 - 9.4 6.4 7.6 1.3 9.2 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3709) API5 PF05918.11 PIK55492.1 - 0.031 13.1 0.2 0.04 12.7 0.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Inhibitor_I36 PF03995.13 PIK55492.1 - 0.074 13.0 0.1 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Peptidase inhibitor family I36 Mpp10 PF04006.12 PIK55492.1 - 0.67 8.3 16.0 0.85 8.0 16.0 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 PIK55492.1 - 1.1 7.3 12.8 1.4 7.0 12.8 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 PIK55492.1 - 2.7 7.2 11.7 4.6 6.5 11.7 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 PIK55492.1 - 6.7 4.9 9.2 7.3 4.8 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein PX PF00787.24 PIK55494.1 - 8.5e-16 57.9 0.2 1.6e-15 57.1 0.2 1.4 1 0 0 1 1 1 1 PX domain PDZ PF00595.24 PIK55494.1 - 0.05 14.0 0.0 0.087 13.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain SHIPPO-rpt PF07004.12 PIK55495.1 - 2.7e-09 37.5 29.4 0.15 13.0 0.1 6.2 4 2 0 4 4 4 4 Sperm-tail PG-rich repeat PCI PF01399.27 PIK55496.1 - 1.4e-24 86.6 3.2 1.4e-24 86.6 3.2 2.3 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 PIK55496.1 - 0.0055 16.6 8.4 33 4.8 0.0 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat Gemini_V2 PF01524.17 PIK55496.1 - 0.13 12.4 0.4 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 Geminivirus V2 protein Bac_rhamnosid6H PF17389.2 PIK55496.1 - 0.73 9.0 4.6 5.6 6.1 4.6 2.0 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DpnI_C PF17726.1 PIK55496.1 - 1.8 8.8 8.5 3.4 7.8 1.2 3.0 2 0 0 2 2 2 0 Dam-replacing HTH domain LZ3wCH PF18517.1 PIK55496.1 - 3.8 7.7 7.3 2 8.6 0.2 3.9 3 1 0 3 3 3 0 Leucine zipper with capping helix domain FAM219A PF15260.6 PIK55497.1 - 2.8e-37 127.9 2.6 3.5e-37 127.6 2.6 1.1 1 0 0 1 1 1 1 Protein family FAM219A WD40 PF00400.32 PIK55498.1 - 7.7e-10 39.2 11.8 0.056 14.3 1.2 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55498.1 - 2.2e-07 31.1 0.3 0.97 9.8 0.0 5.2 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Itfg2 PF15907.5 PIK55498.1 - 0.2 10.6 3.2 0.24 10.4 0.0 2.4 3 0 0 3 3 3 0 Integrin-alpha FG-GAP repeat-containing protein 2 tify PF06200.14 PIK55498.1 - 0.27 10.6 0.8 3.3 7.1 0.3 2.6 2 0 0 2 2 2 0 tify domain DUF5339 PF17274.2 PIK55498.1 - 0.42 11.5 8.0 0.35 11.7 5.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5339) MFS_2 PF13347.6 PIK55499.1 - 8.6e-45 153.1 23.8 1e-44 152.8 23.8 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 PIK55499.1 - 3.4e-20 72.3 41.6 2.9e-15 56.0 20.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily LPAM_1 PF08139.12 PIK55499.1 - 0.038 14.5 0.9 0.43 11.2 0.9 3.0 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DPM3 PF08285.11 PIK55499.1 - 0.053 13.7 4.0 0.65 10.2 0.0 3.4 2 1 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) EFG_IV PF03764.18 PIK55500.1 - 1.8e-31 108.4 0.1 4.2e-31 107.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 PIK55500.1 - 2.5e-23 81.9 0.0 4.9e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 PIK55500.1 - 7.2e-14 51.6 0.0 1.6e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 PIK55500.1 - 3.9e-13 49.6 0.0 1.3e-12 47.9 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 TetR_C_25 PF17933.1 PIK55500.1 - 0.058 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain GTP_EFTU PF00009.27 PIK55501.1 - 1.1e-37 129.5 0.0 1.3e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK55501.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK55502.1 - 1.2e-19 70.6 0.8 1.5e-19 70.3 0.8 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FAT PF02259.23 PIK55504.1 - 1.3e-44 152.8 4.6 1.3e-44 152.8 4.6 3.4 3 1 0 3 3 3 1 FAT domain UME PF08064.13 PIK55504.1 - 2.2e-18 66.0 1.5 3.2e-17 62.3 0.0 3.7 4 0 0 4 4 4 1 UME (NUC010) domain TPR_2 PF07719.17 PIK55504.1 - 0.00019 21.3 0.2 0.0023 17.9 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55504.1 - 0.00077 19.1 0.2 0.0046 16.6 0.1 2.3 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 PIK55504.1 - 0.0009 19.7 2.2 0.0027 18.2 0.4 2.9 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK55504.1 - 0.0012 18.6 2.0 0.0016 18.2 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55504.1 - 0.0018 18.3 1.3 0.0054 16.8 0.0 2.7 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55504.1 - 0.049 13.9 0.7 0.26 11.6 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55504.1 - 0.063 14.1 0.0 16 6.6 0.0 4.6 3 1 2 5 5 4 0 Tetratricopeptide repeat TAN PF11640.8 PIK55504.1 - 0.16 12.0 6.3 1.4 9.0 0.8 3.7 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair RTP1_C1 PF10363.9 PIK55504.1 - 0.3 11.3 2.7 1.2 9.4 0.0 3.5 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 FATC PF02260.20 PIK55505.1 - 5.8e-17 61.2 0.0 8.5e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 FATC domain PI3_PI4_kinase PF00454.27 PIK55505.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Myotub-related PF06602.14 PIK55506.1 - 2.2e-54 184.7 10.3 4.8e-39 134.3 3.3 3.1 1 1 2 3 3 3 3 Myotubularin-like phosphatase domain 3-PAP PF12578.8 PIK55506.1 - 2.8e-13 49.8 0.0 1.4e-12 47.5 0.0 2.0 2 0 0 2 2 2 1 Myotubularin-associated protein Zip PF02535.22 PIK55508.1 - 6.1e-63 213.0 11.5 7.2e-63 212.8 11.5 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4653 PF15546.6 PIK55508.1 - 0.064 12.9 0.2 0.085 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) RVT_1 PF00078.27 PIK55509.1 - 2.8e-21 76.1 0.0 5.5e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotrans_gag PF03732.17 PIK55509.1 - 2.9e-05 24.2 0.0 0.00017 21.8 0.0 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 PIK55509.1 - 0.0067 17.0 0.0 0.016 15.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease DUF4148 PF13663.6 PIK55509.1 - 0.087 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) gag-asp_proteas PF13975.6 PIK55509.1 - 0.091 13.3 0.0 0.28 11.8 0.0 1.9 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK55509.1 - 0.36 11.0 9.9 0.31 11.2 1.1 2.7 2 0 0 2 2 2 0 Zinc knuckle PolC_DP2 PF03833.13 PIK55509.1 - 0.55 8.0 6.4 0.76 7.6 6.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 MtN3_slv PF03083.16 PIK55511.1 - 5.5e-37 125.7 21.4 5.2e-20 71.3 1.6 2.4 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 PIK55511.1 - 0.29 11.2 8.4 1.4 9.1 0.2 3.4 2 1 2 4 4 4 0 Lipid A Biosynthesis N-terminal domain DUF1218 PF06749.12 PIK55511.1 - 1.2 9.7 8.7 0.62 10.6 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) SirB PF04247.12 PIK55511.1 - 3.5 7.7 14.9 0.28 11.3 8.0 2.2 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB GLTP PF08718.11 PIK55512.1 - 7.2e-35 120.5 0.1 9.5e-35 120.1 0.1 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) CPSase_L_D2 PF02786.17 PIK55512.1 - 0.00076 19.0 0.1 0.12 11.8 0.1 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 PIK55512.1 - 0.06 12.9 0.1 0.14 11.8 0.1 1.7 2 0 0 2 2 2 0 ATP-grasp domain zf-RING_2 PF13639.6 PIK55513.1 - 2.4e-13 50.2 7.7 2.4e-13 50.2 7.7 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK55513.1 - 7.6e-09 35.3 8.2 7.6e-09 35.3 8.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK55513.1 - 2.1e-08 33.7 2.9 2.1e-08 33.7 2.9 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 PIK55513.1 - 2e-07 31.2 8.1 2e-07 31.2 8.1 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK55513.1 - 3.6e-07 29.9 6.4 3.6e-07 29.9 6.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK55513.1 - 2.2e-06 27.4 5.1 2.2e-06 27.4 5.1 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK55513.1 - 5.1e-06 26.4 5.5 5.1e-06 26.4 5.5 2.1 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK55513.1 - 3.7e-05 23.6 5.0 3.7e-05 23.6 5.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK55513.1 - 5e-05 23.1 11.1 0.0006 19.6 7.9 3.0 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 Vps39_2 PF10367.9 PIK55513.1 - 5.6e-05 23.5 4.9 0.029 14.8 0.2 2.5 1 1 1 2 2 2 2 Vacuolar sorting protein 39 domain 2 Rad50_zn_hook PF04423.14 PIK55513.1 - 7.2e-05 22.5 3.7 0.26 11.1 0.1 3.2 3 0 0 3 3 3 2 Rad50 zinc hook motif zf-ANAPC11 PF12861.7 PIK55513.1 - 9.9e-05 22.3 2.1 9.9e-05 22.3 2.1 1.7 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_9 PF14369.6 PIK55513.1 - 0.00036 20.7 3.2 0.015 15.6 0.3 3.2 3 0 0 3 3 3 1 zinc-ribbon zf-RING_4 PF14570.6 PIK55513.1 - 0.0023 17.7 6.5 0.056 13.2 5.2 2.7 2 1 1 3 3 3 1 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 PIK55513.1 - 0.0069 16.0 3.6 0.0069 16.0 3.6 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 PIK55513.1 - 0.0077 16.0 4.9 0.021 14.7 4.9 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf_Rg PF17915.1 PIK55513.1 - 0.018 14.4 1.7 17 4.9 0.0 3.4 3 0 0 3 3 3 0 Reverse gyrase zinc finger Evr1_Alr PF04777.13 PIK55513.1 - 0.057 13.9 1.0 0.42 11.1 0.1 2.4 2 1 0 2 2 2 0 Erv1 / Alr family Prok-RING_1 PF14446.6 PIK55513.1 - 0.077 12.9 7.6 0.51 10.3 1.8 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DUF983 PF06170.12 PIK55513.1 - 0.081 13.3 0.7 19 5.7 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF983) DUF1272 PF06906.11 PIK55513.1 - 0.11 12.6 6.4 2.4 8.3 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-HC5HC2H_2 PF13832.6 PIK55513.1 - 0.13 12.5 1.5 0.31 11.2 0.8 1.8 1 1 1 2 2 2 0 PHD-zinc-finger like domain OrfB_Zn_ribbon PF07282.11 PIK55513.1 - 0.32 10.9 2.9 0.53 10.2 0.1 2.5 3 0 0 3 3 3 0 Putative transposase DNA-binding domain FANCL_C PF11793.8 PIK55513.1 - 0.35 11.1 4.9 2 8.6 4.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Zn-C2H2_12 PF18112.1 PIK55513.1 - 0.41 11.1 7.3 0.44 11.1 0.2 3.2 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 PIK55513.1 - 0.51 10.7 10.3 4.6 7.6 6.7 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding TRAF6_Z2 PF18048.1 PIK55513.1 - 0.58 10.3 4.4 9.7 6.4 0.4 3.6 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 PHD PF00628.29 PIK55513.1 - 0.67 9.9 8.7 1.5 8.8 5.4 2.5 2 1 0 2 2 2 0 PHD-finger zf-FPG_IleRS PF06827.14 PIK55513.1 - 1.2 9.1 7.6 4.1 7.3 0.1 3.1 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS zf-C3H2C3 PF17122.5 PIK55513.1 - 2.1 8.5 14.2 2.9 8.0 4.4 3.3 3 0 0 3 3 3 0 Zinc-finger zf-RING_10 PF16685.5 PIK55513.1 - 2.3 8.4 5.2 2.9 8.1 3.8 1.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 PIK55513.1 - 2.6 8.1 5.2 8.1 6.5 2.8 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-C3HC4_4 PF15227.6 PIK55513.1 - 3 8.1 8.9 2 8.6 4.4 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C2H2_4 PF13894.6 PIK55513.1 - 3.1 8.9 6.2 23 6.2 0.3 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-RING-like PF08746.11 PIK55513.1 - 8.1 6.8 10.3 0.27 11.6 4.2 1.8 2 0 0 2 2 1 0 RING-like domain FBPase PF00316.20 PIK55514.1 - 1.4e-71 239.9 0.1 1.9e-71 239.5 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 PIK55514.1 - 0.039 13.5 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family Ldl_recept_a PF00057.18 PIK55515.1 - 3.9e-13 49.4 33.3 1.9e-08 34.4 11.9 5.2 5 1 0 5 5 5 2 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK55515.1 - 0.0028 17.5 0.3 0.0028 17.5 0.3 4.6 4 0 0 4 4 4 3 Complement Clr-like EGF-like hEGF PF12661.7 PIK55515.1 - 0.025 15.2 2.2 0.025 15.2 2.2 6.1 8 1 1 9 9 9 0 Human growth factor-like EGF EGF_CA PF07645.15 PIK55515.1 - 0.035 14.3 8.3 0.035 14.3 8.3 6.0 4 1 0 4 4 4 0 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK55515.1 - 0.094 13.0 0.1 0.094 13.0 0.1 5.5 4 2 1 5 5 5 0 Coagulation Factor Xa inhibitory site LRR_8 PF13855.6 PIK55516.1 - 1.6e-46 155.9 60.6 3.9e-12 45.8 6.3 6.5 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK55516.1 - 2.8e-22 78.4 47.4 4.8e-05 23.6 1.4 7.8 7 1 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK55516.1 - 1.8e-09 37.7 3.2 5.1e-05 23.2 0.7 3.1 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK55516.1 - 7.8e-08 32.0 19.8 0.00085 18.9 0.9 4.3 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 PIK55516.1 - 0.00059 20.0 39.2 0.15 12.7 0.1 11.0 10 2 0 10 10 10 3 Leucine Rich Repeat SlyX PF04102.12 PIK55517.1 - 0.022 15.4 0.0 0.054 14.1 0.0 1.6 1 0 0 1 1 1 0 SlyX Sec3_C PF09763.9 PIK55517.1 - 0.023 13.1 0.2 0.032 12.6 0.2 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 CHASE7 PF17151.4 PIK55517.1 - 0.11 12.1 0.2 0.17 11.5 0.2 1.2 1 0 0 1 1 1 0 Periplasmic sensor domain UDPG_MGDP_dh_N PF03721.14 PIK55518.1 - 3.3e-45 154.0 0.1 3.8e-45 153.8 0.1 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 PIK55518.1 - 0.0018 18.4 0.0 0.35 10.9 0.0 2.1 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 PIK55518.1 - 0.05 13.5 0.0 0.12 12.2 0.0 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 PIK55518.1 - 0.06 13.5 0.0 0.2 11.8 0.0 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 PIK55518.1 - 0.1 12.6 0.0 0.21 11.5 0.0 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_C PF03720.15 PIK55519.1 - 8e-36 122.7 0.0 1.5e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 PIK55519.1 - 4.2e-17 62.1 0.0 1.6e-16 60.3 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 PIK55519.1 - 6.9e-10 38.8 0.0 1.1e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Hexapep PF00132.24 PIK55520.1 - 1.1e-10 40.8 8.1 0.00047 19.8 0.1 4.6 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 PIK55520.1 - 2.6e-08 33.7 0.0 6.4e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase W2 PF02020.18 PIK55520.1 - 2.8e-05 24.1 0.1 8.6e-05 22.6 0.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DUF4954 PF16314.5 PIK55520.1 - 0.0019 16.4 7.2 0.022 12.9 0.2 3.0 2 1 1 3 3 3 3 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 PIK55520.1 - 0.068 13.5 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain Hexapep_2 PF14602.6 PIK55520.1 - 0.09 12.6 12.0 3 7.7 4.5 4.5 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase ASC PF00858.24 PIK55521.1 - 3.8e-55 187.6 0.2 2.1e-27 96.2 5.0 2.1 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel ASC PF00858.24 PIK55522.1 - 2.6e-19 69.5 0.0 3.2e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Laminin_G_1 PF00054.23 PIK55523.1 - 7.7e-36 123.2 0.2 1.8e-17 63.8 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 PIK55523.1 - 1.6e-32 112.7 0.1 4.8e-18 65.9 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.6 PIK55523.1 - 0.00061 20.0 0.4 0.14 12.3 0.0 2.5 2 1 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Laminin_EGF PF00053.24 PIK55524.1 - 1.3e-77 255.7 185.4 1.7e-10 40.8 10.6 11.5 10 1 1 11 11 11 11 Laminin EGF domain Laminin_G_2 PF02210.24 PIK55524.1 - 1.1e-42 145.6 0.0 4.4e-13 49.9 0.0 4.4 4 0 0 4 4 4 3 Laminin G domain Laminin_G_1 PF00054.23 PIK55524.1 - 3.1e-36 124.5 0.1 2e-12 47.4 0.1 3.6 3 0 0 3 3 3 3 Laminin G domain Laminin_B PF00052.18 PIK55524.1 - 3.4e-13 49.7 0.0 8.2e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_G_3 PF13385.6 PIK55524.1 - 7.7e-07 29.4 7.3 0.0006 20.0 0.1 4.3 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily Laminin_II PF06009.12 PIK55524.1 - 7.9e-05 22.7 5.5 7.9e-05 22.7 5.5 4.5 4 0 0 4 4 4 2 Laminin Domain II FliT PF05400.13 PIK55524.1 - 0.054 14.3 1.5 0.2 12.5 1.5 2.0 1 0 0 1 1 1 0 Flagellar protein FliT TMF_DNA_bd PF12329.8 PIK55524.1 - 0.058 13.4 6.0 1.7 8.7 0.2 3.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Seryl_tRNA_N PF02403.22 PIK55524.1 - 0.15 12.3 13.5 0.45 10.8 0.7 3.2 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 PIK55524.1 - 0.44 11.0 18.5 0.68 10.3 2.6 4.0 3 1 1 4 4 4 0 Fez1 DUF4988 PF16378.5 PIK55524.1 - 1.2 8.8 10.8 0.64 9.7 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function PspA_IM30 PF04012.12 PIK55524.1 - 1.7 8.2 13.9 0.62 9.6 0.2 3.3 3 0 0 3 3 3 0 PspA/IM30 family DUF4795 PF16043.5 PIK55524.1 - 8.9 5.9 11.6 1.1 8.9 5.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Pkinase PF00069.25 PIK55525.1 - 7e-05 22.3 0.0 0.0003 20.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain DUF4692 PF15763.5 PIK55525.1 - 2.7 8.4 6.7 0.43 11.0 2.1 2.0 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Aminotran_1_2 PF00155.21 PIK55527.1 - 1.5e-45 156.0 0.0 2.1e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PEHE PF15275.6 PIK55528.1 - 8e-07 29.7 0.4 8e-07 29.7 0.4 3.8 4 0 0 4 4 4 1 PEHE domain N-glycanase_C PF09113.10 PIK55529.1 - 9.3e-39 132.3 0.1 1.7e-38 131.5 0.1 1.5 1 0 0 1 1 1 1 Peptide-N-glycosidase F, C terminal N-glycanase_N PF09112.10 PIK55529.1 - 3.6e-21 75.7 0.0 7.9e-20 71.4 0.0 2.4 1 1 0 1 1 1 1 Peptide-N-glycosidase F, N terminal PA PF02225.22 PIK55529.1 - 1.4e-05 25.0 0.0 3.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 PA domain Hydrolase_6 PF13344.6 PIK55530.1 - 3.1e-18 65.8 0.0 5.3e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK55530.1 - 9.6e-18 64.0 0.0 1.7e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 PIK55530.1 - 7.9e-11 42.3 0.1 9.2e-07 29.1 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK55530.1 - 5.4e-06 26.8 0.1 0.036 14.3 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 PIK55530.1 - 0.16 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Pyridoxal_deC PF00282.19 PIK55531.1 - 3.2e-159 529.6 0.0 8.4e-159 528.3 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 PIK55531.1 - 5.2e-05 22.7 0.0 0.00015 21.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 PIK55531.1 - 0.005 15.8 0.0 0.0085 15.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK55531.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II SepSecS PF05889.13 PIK55531.1 - 0.042 12.6 0.0 0.063 12.0 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.17 PIK55531.1 - 0.043 13.1 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-LSD1 PF06943.12 PIK55531.1 - 0.84 9.5 2.8 1.5 8.7 2.8 1.4 1 0 0 1 1 1 0 LSD1 zinc finger XLF PF09302.11 PIK55532.1 - 4.7e-27 95.3 0.1 6.7e-27 94.8 0.1 1.2 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component CRIC_ras_sig PF10534.9 PIK55532.1 - 0.014 15.5 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras CSD PF00313.22 PIK55534.1 - 2.3e-65 216.4 25.5 1.6e-12 47.1 0.0 8.5 9 0 0 9 9 9 6 'Cold-shock' DNA-binding domain S1-like PF14444.6 PIK55534.1 - 2.6e-09 36.9 14.2 0.49 10.4 0.0 6.4 6 0 0 6 6 6 5 S1-like SUZ-C PF12901.7 PIK55534.1 - 3e-06 27.1 1.0 6.4e-06 26.1 0.1 2.0 2 0 0 2 2 2 1 SUZ-C motif RsgA_N PF16745.5 PIK55534.1 - 0.019 14.7 0.8 13 5.7 0.0 3.7 4 0 0 4 4 4 0 RsgA N-terminal domain OB_RNB PF08206.11 PIK55534.1 - 0.032 13.9 16.0 1.4 8.6 0.1 5.0 5 0 0 5 5 5 0 Ribonuclease B OB domain DUF2196 PF09962.9 PIK55534.1 - 0.074 13.0 0.1 12 5.9 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2196) RVT_1 PF00078.27 PIK55536.1 - 7e-20 71.5 0.1 9.2e-20 71.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EF_assoc_2 PF08356.12 PIK55536.1 - 0.0033 17.4 0.2 0.44 10.6 0.0 2.3 2 0 0 2 2 2 2 EF hand associated DUF3487 PF11990.8 PIK55536.1 - 0.084 12.8 0.2 0.19 11.6 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3487) gag-asp_proteas PF13975.6 PIK55537.1 - 0.0021 18.6 0.0 0.0059 17.1 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK55537.1 - 0.003 18.2 0.0 0.011 16.3 0.0 2.0 1 1 1 2 2 2 1 Aspartyl protease RVP PF00077.20 PIK55537.1 - 0.0032 17.7 0.0 0.011 16.0 0.0 1.9 1 1 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK55537.1 - 0.0054 16.8 11.1 0.053 13.6 1.7 2.5 2 0 0 2 2 2 2 Zinc knuckle RVT_1 PF00078.27 PIK55537.1 - 0.0088 15.6 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_3 PF13917.6 PIK55537.1 - 1.7 8.7 11.1 1 9.4 0.2 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55537.1 - 9.6 6.1 9.2 0.3 10.9 0.9 2.3 2 0 0 2 2 2 0 Zinc knuckle GDP_Man_Dehyd PF16363.5 PIK55538.1 - 6.9e-22 78.3 0.0 1e-21 77.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Integrase_H2C2 PF17921.1 PIK55538.1 - 5.7e-17 61.6 0.2 1.1e-16 60.7 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Epimerase PF01370.21 PIK55538.1 - 2e-16 60.2 0.0 3e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family rve PF00665.26 PIK55538.1 - 1.9e-12 47.4 0.0 5.2e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK55538.1 - 0.00056 20.1 0.3 0.0012 19.0 0.3 1.6 1 0 0 1 1 1 1 H2C2 zinc finger DUF2403 PF10290.9 PIK55538.1 - 0.078 13.4 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 Glycine-rich protein domain (DUF2403) Polysacc_synt_2 PF02719.15 PIK55538.1 - 0.092 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RVT_1 PF00078.27 PIK55539.1 - 5.6e-16 58.7 0.1 7e-16 58.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flagellin_C PF00700.21 PIK55539.1 - 0.19 12.1 2.5 0.38 11.1 0.5 2.2 2 1 1 3 3 3 0 Bacterial flagellin C-terminal helical region Cys_rich_FGFR PF00839.17 PIK55540.1 - 2.7e-22 78.7 5.6 1.5e-13 50.6 1.1 2.1 2 0 0 2 2 2 2 Cysteine rich repeat Aldolase_II PF00596.21 PIK55541.1 - 1.7e-30 106.3 1.0 2.4e-30 105.8 1.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain AAA PF00004.29 PIK55542.1 - 6.5e-42 143.1 0.0 2e-41 141.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 PIK55542.1 - 2.1e-26 91.7 0.1 6.7e-26 90.1 0.0 1.9 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 PIK55542.1 - 7.6e-24 83.6 7.0 2.1e-23 82.2 7.0 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 PIK55542.1 - 4.3e-06 27.2 0.1 0.00079 19.8 0.0 2.7 2 1 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 PIK55542.1 - 1.8e-05 24.1 0.0 3.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 PIK55542.1 - 3.4e-05 23.9 0.0 0.00011 22.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 PIK55542.1 - 3.5e-05 23.6 0.0 0.00018 21.3 0.0 2.1 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_lid_3 PF17862.1 PIK55542.1 - 3.5e-05 23.5 0.0 0.00014 21.5 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 PIK55542.1 - 5e-05 23.3 0.0 0.00017 21.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK55542.1 - 5.6e-05 23.4 0.6 0.0023 18.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 PIK55542.1 - 9.2e-05 21.7 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 PIK55542.1 - 0.0001 22.1 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 PIK55542.1 - 0.0001 22.5 0.1 0.0008 19.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 PIK55542.1 - 0.00065 20.2 0.2 0.0023 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 PIK55542.1 - 0.0012 18.4 0.3 0.79 9.3 0.1 2.6 2 1 1 3 3 2 1 AAA domain RNA_helicase PF00910.22 PIK55542.1 - 0.0032 17.8 0.0 0.013 15.9 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_33 PF13671.6 PIK55542.1 - 0.0048 17.1 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK55542.1 - 0.0053 16.5 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK55542.1 - 0.013 15.0 0.0 0.038 13.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Dzip-like_N PF13815.6 PIK55542.1 - 0.023 14.7 1.7 0.05 13.6 1.7 1.5 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal AAA_17 PF13207.6 PIK55542.1 - 0.023 15.1 0.3 0.068 13.6 0.0 2.0 2 1 0 2 2 1 0 AAA domain USP8_dimer PF08969.11 PIK55542.1 - 0.028 14.6 4.8 0.07 13.3 4.8 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain Mg_chelatase PF01078.21 PIK55542.1 - 0.032 13.6 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 PIK55542.1 - 0.045 13.7 0.0 0.26 11.2 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Parvo_NS1 PF01057.17 PIK55542.1 - 0.046 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 PIK55542.1 - 0.048 13.1 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 PIK55542.1 - 0.053 13.3 3.0 4.4 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 PIK55542.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.11 PIK55542.1 - 0.063 12.7 0.0 11 5.4 0.0 2.6 1 1 0 2 2 2 0 Bacterial TniB protein ATPase_2 PF01637.18 PIK55542.1 - 0.063 13.2 3.5 0.84 9.5 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 PIK55542.1 - 0.071 12.3 1.7 6.1 6.0 0.1 2.9 2 1 1 3 3 3 0 KAP family P-loop domain ATPase PF06745.13 PIK55542.1 - 0.077 12.3 1.1 8.4 5.7 0.0 2.6 2 1 1 3 3 3 0 KaiC TPR_2 PF07719.17 PIK55542.1 - 0.27 11.4 3.5 0.48 10.7 0.7 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF3149 PF11346.8 PIK55543.1 - 0.027 14.1 0.3 0.048 13.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Shisa PF13908.6 PIK55543.1 - 0.064 13.5 0.4 0.12 12.6 0.4 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK55543.1 - 0.064 13.2 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Vesiculo_matrix PF06326.12 PIK55543.1 - 0.1 12.4 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 Vesiculovirus matrix protein Ldl_recept_b PF00058.17 PIK55544.1 - 4.9e-08 33.3 1.2 0.00063 20.2 0.0 2.6 2 1 0 2 2 2 2 Low-density lipoprotein receptor repeat class B HYR PF02494.16 PIK55544.1 - 9.6e-05 22.6 0.1 0.00019 21.7 0.1 1.5 1 0 0 1 1 1 1 HYR domain FXa_inhibition PF14670.6 PIK55544.1 - 1.9 8.8 6.8 0.32 11.3 2.6 1.9 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site EH_Signature PF15611.6 PIK55545.1 - 0.034 13.6 0.0 0.35 10.2 0.0 2.1 2 0 0 2 2 2 0 EH_Signature domain Sushi PF00084.20 PIK55546.1 - 4.8e-57 190.4 88.1 3.9e-11 43.4 7.8 9.5 9 0 0 9 9 9 9 Sushi repeat (SCR repeat) HYR PF02494.16 PIK55546.1 - 9.9e-30 102.7 10.1 9.6e-16 57.9 3.2 2.8 2 0 0 2 2 2 2 HYR domain DUF5011 PF16403.5 PIK55546.1 - 0.09 12.9 0.2 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) SusE PF14292.6 PIK55546.1 - 0.16 12.2 4.6 0.083 13.1 0.7 2.4 3 0 0 3 3 3 0 SusE outer membrane protein HYR PF02494.16 PIK55547.1 - 1e-25 89.8 16.2 1.4e-10 41.3 0.4 4.9 4 0 0 4 4 4 4 HYR domain EGF PF00008.27 PIK55547.1 - 2.7e-25 88.3 85.3 4.1e-08 33.4 9.1 8.6 8 0 0 8 8 8 5 EGF-like domain Ephrin_rec_like PF07699.13 PIK55547.1 - 1.1e-22 79.5 36.6 1.5e-11 43.9 7.9 5.2 4 0 0 4 4 4 3 Putative ephrin-receptor like Sushi PF00084.20 PIK55547.1 - 9.2e-17 61.4 53.7 9.4e-07 29.3 3.1 8.3 8 0 0 8 8 8 4 Sushi repeat (SCR repeat) hEGF PF12661.7 PIK55547.1 - 5.1e-07 30.1 30.1 3.9e-05 24.1 5.1 10.0 11 1 0 11 11 11 4 Human growth factor-like EGF EGF_CA PF07645.15 PIK55547.1 - 0.0039 17.4 9.6 0.0039 17.4 9.6 11.7 10 1 2 12 12 12 4 Calcium-binding EGF domain Big_3_4 PF13754.6 PIK55547.1 - 0.011 15.5 0.0 20 4.9 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function Big_3_2 PF12245.8 PIK55547.1 - 0.12 12.7 0.3 6.9 7.0 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain DUF5011 PF16403.5 PIK55547.1 - 0.13 12.4 0.7 38 4.5 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) EGF PF00008.27 PIK55548.1 - 3.3e-33 113.6 50.2 1.8e-09 37.7 4.1 6.3 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK55548.1 - 3e-22 78.4 45.6 2.9e-06 27.7 3.7 7.0 6 0 0 6 6 6 6 Human growth factor-like EGF EGF_CA PF07645.15 PIK55548.1 - 4.5e-06 26.8 63.1 3.7e-05 23.8 5.2 5.8 3 1 3 6 6 6 4 Calcium-binding EGF domain EGF_3 PF12947.7 PIK55548.1 - 0.00049 20.2 46.8 0.0094 16.1 3.1 5.8 4 1 1 5 5 5 3 EGF domain EGF_2 PF07974.13 PIK55548.1 - 0.0015 18.9 65.0 0.061 13.7 9.5 5.9 6 0 0 6 6 6 4 EGF-like domain Laminin_EGF PF00053.24 PIK55548.1 - 1.1 9.5 47.3 2.1 8.6 7.6 4.7 2 2 2 4 4 4 0 Laminin EGF domain Glyco_transf_29 PF00777.18 PIK55550.1 - 6.2e-39 134.0 0.6 9.6e-39 133.4 0.2 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK55551.1 - 2.4e-55 187.8 0.7 3e-55 187.5 0.7 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK55552.1 - 5.1e-35 121.2 0.2 6.3e-35 120.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 PIK55553.1 - 7.7e-59 199.3 0.1 9.6e-59 199.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) NTP_transf_7 PF07984.12 PIK55554.1 - 1.1e-117 392.9 1.8 7.1e-60 202.9 0.7 2.1 1 1 1 2 2 2 2 Nucleotidyltransferase NES_C_h PF18208.1 PIK55554.1 - 0.03 14.6 0.0 0.075 13.3 0.0 1.7 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain EF-hand_4 PF12763.7 PIK55555.1 - 4.3e-14 52.3 0.0 9.6e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 PIK55555.1 - 0.0019 18.6 0.0 0.0041 17.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK55555.1 - 0.0036 16.8 0.0 0.012 15.1 0.0 1.9 2 0 0 2 2 2 1 EF hand ZapB PF06005.12 PIK55555.1 - 0.056 13.9 3.8 0.17 12.3 3.8 1.8 1 0 0 1 1 1 0 Cell division protein ZapB DUF2353 PF09789.9 PIK55555.1 - 0.064 12.6 6.1 0.05 13.0 3.9 1.8 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) UPF0561 PF10573.9 PIK55555.1 - 1.8 8.7 9.0 0.039 14.1 1.5 2.1 2 1 0 2 2 2 0 Uncharacterised protein family UPF0561 DUF4515 PF14988.6 PIK55555.1 - 4.5 7.1 11.5 0.081 12.7 4.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) BPL_N PF09825.9 PIK55556.1 - 3.1e-08 33.1 0.4 6.2e-07 28.8 0.0 2.4 2 1 0 2 2 2 1 Biotin-protein ligase, N terminal ABC_transp_aux PF09822.9 PIK55556.1 - 0.046 13.2 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 ABC-type uncharacterized transport system BPL_LplA_LipB PF03099.19 PIK55557.1 - 3.6e-17 62.5 0.0 6.5e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 PIK55557.1 - 3.8e-06 26.7 0.1 7.9e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain PepSY_2 PF13670.6 PIK55557.1 - 0.17 11.9 0.0 0.47 10.5 0.0 1.7 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain ANF_receptor PF01094.28 PIK55558.1 - 2.4e-57 194.7 0.0 2.8e-57 194.4 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK55558.1 - 3.1e-09 37.0 0.0 4.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein 7tm_3 PF00003.22 PIK55559.1 - 6e-19 68.7 6.3 7.7e-19 68.4 6.3 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1218 PF06749.12 PIK55559.1 - 0.29 11.7 4.8 0.088 13.3 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Cytomega_TRL10 PF06084.11 PIK55559.1 - 0.72 9.9 1.9 0.94 9.5 0.9 1.6 1 1 1 2 2 2 0 Cytomegalovirus TRL10 protein Pkinase PF00069.25 PIK55560.1 - 6.9e-31 107.6 0.0 1.1e-30 107.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55560.1 - 1.1e-15 57.6 0.0 1.5e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK55560.1 - 0.0029 17.0 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK55560.1 - 0.06 13.2 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M24 PF00557.24 PIK55561.1 - 2.1e-36 125.6 0.0 4.3e-36 124.6 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 PIK55561.1 - 4.8e-23 82.0 0.1 5.1e-22 78.7 0.0 2.4 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 PIK55561.1 - 5.5e-11 42.4 0.0 1.8e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 PIK55561.1 - 8.8e-11 42.6 0.0 2.7e-10 41.0 0.0 1.8 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain SH3BGR PF04908.15 PIK55562.1 - 1.1e-14 54.3 0.1 1.3e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein DUF1204 PF06721.11 PIK55562.1 - 0.024 14.1 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) DUF2654 PF10849.8 PIK55562.1 - 0.046 13.9 0.1 0.059 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) BT1 PF03092.16 PIK55562.1 - 0.18 10.0 0.1 0.19 9.9 0.1 1.0 1 0 0 1 1 1 0 BT1 family SH3BGR PF04908.15 PIK55563.1 - 2.8e-20 72.3 0.1 3.3e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 PIK55563.1 - 0.0046 17.2 0.0 0.0058 16.8 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin LLGL PF08366.13 PIK55564.1 - 3e-19 69.3 0.1 1.4e-18 67.1 0.0 2.1 2 0 0 2 2 2 1 LLGL2 Lgl_C PF08596.10 PIK55564.1 - 2.7e-09 36.2 0.1 1.6e-08 33.7 0.0 2.3 4 0 0 4 4 4 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 PIK55564.1 - 5.1e-07 30.3 5.3 0.018 15.9 0.2 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Synaptobrevin PF00957.21 PIK55564.1 - 5.2e-05 23.0 0.8 5.2e-05 23.0 0.8 1.9 2 0 0 2 2 2 1 Synaptobrevin ANAPC4_WD40 PF12894.7 PIK55564.1 - 0.00032 20.9 0.2 0.062 13.6 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 PIK55564.1 - 0.0076 14.6 0.0 0.016 13.5 0.0 1.4 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz RVT_1 PF00078.27 PIK55566.1 - 0.00042 19.9 0.0 0.00072 19.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4614 PF15391.6 PIK55567.1 - 7 6.6 8.4 18 5.2 8.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) EF-hand_7 PF13499.6 PIK55569.1 - 9.5e-07 29.2 1.2 1.7e-06 28.4 1.2 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK55569.1 - 4.9e-05 23.1 0.1 0.005 16.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK55569.1 - 0.0028 17.1 0.4 0.31 10.7 0.1 2.3 2 0 0 2 2 2 2 EF hand UME PF08064.13 PIK55569.1 - 0.0092 15.9 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 UME (NUC010) domain EF-hand_6 PF13405.6 PIK55569.1 - 0.056 13.4 0.3 1.4 9.1 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain F-box-like PF12937.7 PIK55570.1 - 2.6e-07 30.4 0.2 5.8e-07 29.3 0.2 1.7 1 0 0 1 1 1 1 F-box-like DUF4347 PF14252.6 PIK55570.1 - 3.3e-07 30.3 0.0 7e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) DUF4508 PF14969.6 PIK55570.1 - 0.0012 19.1 0.0 0.0041 17.3 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) RhoGEF PF00621.20 PIK55570.1 - 0.019 15.2 0.2 0.065 13.5 0.0 2.1 2 0 0 2 2 2 0 RhoGEF domain F-box PF00646.33 PIK55570.1 - 0.15 12.0 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 F-box domain Imm74 PF15603.6 PIK55570.1 - 1.3 9.3 3.2 1.2e+02 3.0 0.6 3.2 3 0 0 3 3 3 0 Immunity protein 74 DUF2120 PF09893.9 PIK55570.1 - 8.5 6.5 8.4 9.9 6.3 0.1 3.6 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2120) Arf PF00025.21 PIK55571.1 - 3.3e-45 153.7 0.0 4.9e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK55571.1 - 6.1e-08 32.9 0.0 1.3e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 PIK55571.1 - 6.7e-08 32.1 2.9 0.00083 18.6 0.0 3.2 2 1 1 3 3 3 2 G-protein alpha subunit SRPRB PF09439.10 PIK55571.1 - 1.2e-07 31.3 1.0 1.5e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK55571.1 - 3.8e-06 26.9 0.1 1.1e-05 25.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 PIK55571.1 - 2.3e-05 24.1 0.1 3.4e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 PIK55571.1 - 3.8e-05 23.2 0.0 5.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ALMT PF11744.8 PIK55571.1 - 2.9 6.6 4.1 3.8 6.2 4.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EAV_GS PF01309.18 PIK55572.1 - 0.031 13.9 0.1 0.045 13.4 0.1 1.2 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein DUF677 PF05055.12 PIK55572.1 - 0.04 12.8 0.1 0.051 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) SbcCD_C PF13558.6 PIK55572.1 - 0.16 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Pkinase PF00069.25 PIK55573.1 - 3e-22 79.2 0.0 4.8e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55573.1 - 5e-09 35.8 0.0 5.6e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK55573.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK55573.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK55573.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 PIK55574.1 - 1.2e-08 34.2 7.7 1.3e-08 34.1 7.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK55574.1 - 0.00023 20.2 7.4 0.00031 19.7 7.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.24 PIK55575.1 - 2.1e-24 86.2 5.2 2.7e-24 85.9 5.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK55575.1 - 3.2e-14 52.6 12.5 4.2e-14 52.2 12.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TPR_10 PF13374.6 PIK55575.1 - 0.11 12.4 0.5 0.26 11.2 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CcmD PF04995.14 PIK55575.1 - 0.59 10.3 4.1 17 5.6 1.4 3.1 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Dimer_Tnp_hAT PF05699.14 PIK55576.1 - 7e-12 45.0 0.1 1.6e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK55577.1 - 1.7e-22 80.3 0.1 2.7e-22 79.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK55577.1 - 0.0088 15.9 0.6 0.084 12.7 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) DUF3069 PF11269.8 PIK55577.1 - 0.013 15.8 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) DUF4371 PF14291.6 PIK55578.1 - 4.9e-06 26.4 0.1 7.6e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Sugar_tr PF00083.24 PIK55579.1 - 8.8e-28 97.4 16.3 8.8e-28 97.4 16.3 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK55579.1 - 2.2e-19 69.6 31.3 1.7e-13 50.2 21.0 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily NAD_binding_10 PF13460.6 PIK55580.1 - 1.1e-37 129.7 0.0 1.3e-37 129.5 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK55580.1 - 5.4e-08 32.7 0.0 6.7e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 PIK55580.1 - 1.6e-05 24.5 0.1 3.7e-05 23.3 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 PIK55580.1 - 0.081 13.4 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CSN7a_helixI PF18392.1 PIK55580.1 - 0.099 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain Shikimate_DH PF01488.20 PIK55580.1 - 0.14 12.3 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Utp14 PF04615.13 PIK55581.1 - 3.2e-41 141.8 10.8 4e-41 141.5 10.8 1.0 1 0 0 1 1 1 1 Utp14 protein P_C10 PF14974.6 PIK55581.1 - 0.0032 17.5 0.8 0.011 15.8 0.0 2.3 3 0 0 3 3 3 1 Protein C10 DUF919 PF06034.11 PIK55581.1 - 1.2 9.0 5.9 0.24 11.2 1.6 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Cep57_CLD PF14073.6 PIK55582.1 - 3.4e-51 173.8 35.0 3.4e-51 173.8 35.0 2.4 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.13 PIK55582.1 - 2e-18 66.6 0.9 2e-18 66.6 0.9 4.7 3 1 1 5 5 5 1 Centrosome microtubule-binding domain of Cep57 Lebercilin PF15619.6 PIK55582.1 - 0.49 10.0 55.4 0.022 14.4 5.1 3.5 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TMF_TATA_bd PF12325.8 PIK55582.1 - 0.51 10.6 44.2 0.25 11.6 13.6 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding NYD-SP28_assoc PF14775.6 PIK55582.1 - 1.5 9.0 7.7 0.17 12.0 1.7 2.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain HAUS-augmin3 PF14932.6 PIK55582.1 - 2.2 7.8 42.1 0.37 10.3 2.4 3.2 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Baculo_PEP_C PF04513.12 PIK55582.1 - 8.7 6.4 13.3 52 3.9 0.1 3.6 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-H2C2_2 PF13465.6 PIK55583.1 - 2.9e-21 74.9 23.6 4.7e-07 30.0 1.4 5.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55583.1 - 3.6e-17 61.8 35.6 6.8e-05 23.1 2.0 5.0 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55583.1 - 7.4e-10 38.8 33.6 0.0043 17.8 1.9 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK55583.1 - 3.3e-06 27.3 14.9 0.0023 18.2 4.7 2.6 1 1 1 2 2 2 2 C2H2-type zinc ribbon SET PF00856.28 PIK55583.1 - 8.7e-06 26.2 0.0 1.8e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 SET domain zf-met PF12874.7 PIK55583.1 - 0.00045 20.5 24.7 0.026 14.9 1.2 4.7 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK55583.1 - 0.0048 17.1 0.1 0.0048 17.1 0.1 4.5 5 0 0 5 5 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK55583.1 - 0.017 15.1 29.5 0.21 11.6 2.2 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger YceD PF02620.17 PIK55583.1 - 0.39 10.9 1.6 5.8 7.1 0.0 2.7 2 1 1 3 3 3 0 Large ribosomal RNA subunit accumulation protein YceD zf-C2HE PF16278.5 PIK55583.1 - 0.47 10.9 21.2 0.81 10.2 0.4 4.8 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger BolA PF01722.18 PIK55583.1 - 0.68 10.2 6.7 1.1 9.6 0.1 3.0 2 1 1 3 3 2 0 BolA-like protein zf_UBZ PF18439.1 PIK55583.1 - 2.5 7.8 6.9 14 5.4 0.6 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 PIK55583.1 - 3.2 7.8 5.2 35 4.4 5.2 2.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_4 PF07975.12 PIK55583.1 - 4.9 7.5 11.8 3.1 8.1 2.4 3.0 1 1 1 3 3 3 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 PIK55583.1 - 5.2 7.9 7.3 5.5 7.8 1.1 2.5 1 1 0 2 2 2 0 zinc-ribbon family zf-MYST PF17772.1 PIK55583.1 - 8.2 6.1 11.0 27 4.5 0.1 4.1 2 1 2 4 4 4 0 MYST family zinc finger domain SSF PF00474.17 PIK55584.1 - 9.1e-137 456.2 23.1 1.3e-136 455.7 23.1 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family PAN_4 PF14295.6 PIK55584.1 - 0.099 12.6 1.0 0.21 11.5 1.0 1.4 1 0 0 1 1 1 0 PAN domain DUF4271 PF14093.6 PIK55584.1 - 1.4 8.8 30.2 0.7 9.8 14.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) Proteasome PF00227.26 PIK55587.1 - 7e-33 113.7 0.0 8e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit 7tm_1 PF00001.21 PIK55588.1 - 5.6e-20 71.8 4.9 6.7e-20 71.5 4.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55588.1 - 2.3e-12 47.1 11.7 3.4e-12 46.5 11.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55588.1 - 0.00017 21.1 12.9 0.001 18.5 12.9 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK55588.1 - 0.15 11.8 6.9 0.039 13.7 2.5 2.0 1 1 0 2 2 2 0 Olfactory receptor Peptidase_M1 PF01433.20 PIK55589.1 - 5.1e-85 284.5 0.4 1e-84 283.5 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 PIK55589.1 - 7.6e-84 281.9 2.0 1.2e-83 281.3 2.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 PIK55589.1 - 1.8e-47 162.0 0.0 3.6e-47 161.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF4300 PF14133.6 PIK55589.1 - 0.062 13.0 0.1 2.2 7.9 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4300) Peptidase_M1 PF01433.20 PIK55590.1 - 2.5e-87 292.0 0.3 4.5e-87 291.2 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 PIK55590.1 - 9.1e-49 166.2 0.0 1.3e-48 165.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 PIK55590.1 - 2e-42 145.9 1.1 7.3e-24 84.9 0.0 2.6 1 1 1 2 2 2 2 ERAP1-like C-terminal domain DUF4300 PF14133.6 PIK55590.1 - 0.013 15.2 0.5 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4300) Aminopep PF10023.9 PIK55590.1 - 0.045 13.1 0.0 0.098 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative aminopeptidase PP-binding PF00550.25 PIK55590.1 - 0.13 12.6 0.0 3.7 8.0 0.1 2.5 2 0 0 2 2 2 0 Phosphopantetheine attachment site CEBP_ZZ PF16366.5 PIK55591.1 - 1.8e-23 82.5 6.1 2.7e-22 78.8 6.4 2.2 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_7 PF16367.5 PIK55591.1 - 1.5e-21 76.3 0.0 4.1e-21 74.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif RRM_1 PF00076.22 PIK55591.1 - 0.0034 17.2 0.1 1.1 9.1 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COMM_domain PF07258.14 PIK55592.1 - 3.9e-21 74.9 0.3 6.7e-21 74.2 0.3 1.4 1 0 0 1 1 1 1 COMM domain DUF4429 PF14472.6 PIK55592.1 - 0.014 15.9 0.0 0.073 13.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4429) zf-C3HC4_3 PF13920.6 PIK55593.1 - 2e-08 34.0 9.1 2e-08 34.0 9.1 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK55593.1 - 9e-07 29.1 12.7 9e-07 29.1 12.7 3.7 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 PIK55593.1 - 1.6e-06 27.9 11.3 1.6e-06 27.9 11.3 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK55593.1 - 4.4e-06 26.6 12.3 4.4e-06 26.6 12.3 3.2 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK55593.1 - 6.3e-06 25.9 13.2 6.3e-06 25.9 13.2 3.4 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK55593.1 - 0.00042 20.1 11.0 0.00042 20.1 11.0 3.9 4 1 0 4 4 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK55593.1 - 0.0015 18.5 11.1 0.0015 18.5 11.1 3.4 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK55593.1 - 0.0065 16.6 13.0 0.0065 16.6 13.0 3.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 PIK55593.1 - 0.08 12.9 4.0 0.18 11.7 4.0 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Rrn6 PF10214.9 PIK55593.1 - 0.31 9.5 5.9 0.26 9.7 4.7 1.3 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Bac_small_YrzI PF09501.10 PIK55593.1 - 2.6 8.3 5.6 7.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) zf-RING_6 PF14835.6 PIK55593.1 - 4.6 7.2 10.2 0.32 10.9 4.6 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein SSF PF00474.17 PIK55594.1 - 4.5e-42 144.4 22.1 5.7e-42 144.0 22.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family DUF1440 PF07274.12 PIK55594.1 - 1 9.7 4.2 1.8 8.9 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1440) Abhydrolase_9_N PF15420.6 PIK55594.1 - 5.5 6.9 10.1 2.2 8.2 1.7 3.1 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus SSF PF00474.17 PIK55595.1 - 5.4e-22 78.2 10.9 8.2e-22 77.6 10.9 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK55596.1 - 7.2e-18 64.6 10.0 1.1e-17 64.0 10.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family Cuticle_3 PF11018.8 PIK55596.1 - 0.018 15.3 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 Pupal cuticle protein C1 G-alpha PF00503.20 PIK55597.1 - 3.7e-105 352.0 2.4 4.8e-105 351.6 2.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK55597.1 - 6.1e-11 42.1 0.2 2.8e-10 39.9 0.2 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family COesterase PF00135.28 PIK55598.1 - 6.5e-35 121.0 0.1 7.5e-35 120.8 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK55599.1 - 4.7e-112 375.5 0.0 9.3e-63 212.8 0.2 2.0 2 0 0 2 2 2 2 Carboxylesterase family AChE_tetra PF08674.10 PIK55599.1 - 1.9e-05 24.2 5.6 1.9e-05 24.2 5.6 2.0 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.13 PIK55599.1 - 0.06 13.2 0.6 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold COesterase PF00135.28 PIK55600.1 - 5.8e-140 467.6 0.0 6.5e-140 467.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK55600.1 - 1.3e-07 31.7 0.4 1.5e-06 28.2 0.1 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK55600.1 - 6.6e-06 25.7 3.2 6.6e-06 25.7 3.2 2.0 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK55601.1 - 9.1e-130 433.9 0.5 1.3e-108 364.1 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK55601.1 - 9e-10 38.8 0.2 5.4e-09 36.2 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK55601.1 - 0.003 17.2 3.6 0.003 17.2 3.6 2.0 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Peptidase_S9 PF00326.21 PIK55601.1 - 0.039 13.4 0.3 0.039 13.4 0.3 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF773 PF05600.12 PIK55602.1 - 1.9e-177 591.0 17.3 2.2e-177 590.9 17.3 1.0 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 GYF PF02213.16 PIK55602.1 - 0.14 11.9 0.1 0.34 10.6 0.1 1.6 1 0 0 1 1 1 0 GYF domain RNaseH_C PF09293.10 PIK55602.1 - 0.18 12.1 2.1 0.19 12.1 0.1 2.1 2 0 0 2 2 2 0 T4 RNase H, C terminal HIP1_clath_bdg PF16515.5 PIK55602.1 - 0.28 11.8 0.0 0.28 11.8 0.0 3.2 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 STAT_int PF02865.17 PIK55602.1 - 0.46 10.9 6.9 6.5 7.2 0.5 2.9 2 0 0 2 2 2 0 STAT protein, protein interaction domain DUF2203 PF09969.9 PIK55602.1 - 1.3 9.8 10.7 11 6.7 0.0 3.3 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) CREPT PF16566.5 PIK55602.1 - 4.2 7.5 13.0 12 6.1 7.7 3.2 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour zf-C2H2_aberr PF17017.5 PIK55603.1 - 1.3e-05 25.4 0.7 0.00027 21.1 0.1 2.2 2 0 0 2 2 2 1 Aberrant zinc-finger zf-C2H2_4 PF13894.6 PIK55603.1 - 3.8e-05 24.2 2.5 0.024 15.4 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK55603.1 - 0.0038 17.6 3.5 0.45 11.1 0.2 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 PIK55603.1 - 0.0045 16.9 2.7 0.096 12.7 0.1 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK55603.1 - 7.7 7.1 11.1 20 5.8 1.8 3.2 3 0 0 3 3 3 0 Zinc-finger double domain ubiquitin PF00240.23 PIK55605.1 - 2.2e-08 33.7 0.0 3.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 PIK55605.1 - 0.017 15.6 0.0 0.047 14.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain Tim44 PF04280.15 PIK55606.1 - 7.5e-31 107.2 0.1 1.1e-30 106.7 0.1 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 PIK55606.1 - 0.01 14.9 0.0 0.01 14.9 0.0 1.6 2 1 0 2 2 2 0 MBA1-like protein Ion_trans PF00520.31 PIK55607.1 - 7e-08 32.0 12.3 1e-07 31.5 12.3 1.2 1 0 0 1 1 1 1 Ion transport protein NUDIX PF00293.28 PIK55607.1 - 1.7e-06 28.1 0.2 3.6e-06 27.1 0.2 1.5 1 0 0 1 1 1 1 NUDIX domain PKD_channel PF08016.12 PIK55607.1 - 0.011 14.5 9.2 0.022 13.5 9.2 1.4 1 1 0 1 1 1 0 Polycystin cation channel Kazal_2 PF07648.15 PIK55608.1 - 6.9e-05 22.9 1.3 0.00019 21.5 1.3 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK55608.1 - 0.067 13.2 1.8 0.12 12.4 1.8 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DNA_pol_A_exo1 PF01612.20 PIK55609.1 - 8.2e-22 77.7 0.0 1.1e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease Exo84_C PF16528.5 PIK55609.1 - 0.19 11.5 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Exocyst component 84 C-terminal DNA_pol_A_exo1 PF01612.20 PIK55610.1 - 1.1e-22 80.6 0.0 1.5e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease Acetyltransf_1 PF00583.25 PIK55611.1 - 1.4e-10 41.4 0.0 2.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK55611.1 - 2e-07 31.0 0.2 4e-07 30.0 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK55611.1 - 1.8e-06 27.8 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 PIK55611.1 - 9.4e-06 26.0 0.0 3.2e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 PIK55611.1 - 0.0061 16.5 0.1 0.014 15.4 0.1 1.6 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 PIK55611.1 - 0.016 14.7 0.1 0.034 13.6 0.0 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase COP-gamma_platf PF08752.10 PIK55611.1 - 0.042 14.0 0.0 0.082 13.0 0.0 1.5 1 0 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain Acetyltransf_9 PF13527.7 PIK55611.1 - 0.051 13.7 0.0 0.094 12.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Kazal_2 PF07648.15 PIK55612.1 - 7.7e-05 22.7 2.8 0.00015 21.8 2.8 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK55612.1 - 0.0019 18.2 1.0 0.0033 17.4 1.0 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Arm_vescicular PF18770.1 PIK55612.1 - 0.04 13.9 0.4 0.065 13.2 0.4 1.3 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor Nab6_mRNP_bdg PF10567.9 PIK55612.1 - 0.057 12.9 0.6 0.065 12.7 0.6 1.1 1 0 0 1 1 1 0 RNA-recognition motif rve PF00665.26 PIK55613.1 - 5.8e-20 71.7 0.0 7.2e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain 2_5_RNA_ligase2 PF13563.6 PIK55613.1 - 0.0026 17.7 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK55613.1 - 0.022 14.6 0.0 0.054 13.3 0.0 1.8 1 1 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 PIK55614.1 - 7.3e-37 125.4 0.0 1.2e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55614.1 - 3.1e-34 117.4 0.0 5.8e-34 116.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55614.1 - 4.3e-33 114.7 0.1 9.1e-33 113.6 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flu_PB1 PF00602.17 PIK55614.1 - 0.2 9.7 0.0 0.28 9.3 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 DUF1266 PF06889.11 PIK55615.1 - 0.21 11.6 0.8 0.41 10.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) ALS2CR8 PF15299.6 PIK55617.1 - 0.013 15.4 0.6 0.023 14.6 0.1 1.7 2 1 0 2 2 2 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 ALS2CR8 PF15299.6 PIK55618.1 - 8.8e-19 68.3 0.2 1.3e-18 67.7 0.2 1.2 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 FAR1 PF03101.15 PIK55618.1 - 0.097 13.4 0.5 0.39 11.5 0.1 2.1 2 0 0 2 2 2 0 FAR1 DNA-binding domain SNAPc_SNAP43 PF09808.9 PIK55619.1 - 2.5e-30 105.9 5.3 3.8e-30 105.2 5.3 1.3 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Phage_lambda_P PF06992.11 PIK55620.1 - 0.16 11.7 6.8 2.1 8.0 0.1 3.2 1 1 2 3 3 3 0 Replication protein P DUF966 PF06136.13 PIK55620.1 - 0.29 10.8 22.9 0.38 10.4 22.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) LAP1C PF05609.12 PIK55620.1 - 2.1 7.3 26.6 2.8 6.9 26.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RT_RNaseH PF17917.1 PIK55621.1 - 1.3e-26 92.9 0.0 2.1e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK55621.1 - 2e-22 79.1 0.0 3.6e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK55621.1 - 3.4e-14 52.7 0.0 6.9e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK55621.1 - 0.035 14.3 0.0 0.071 13.3 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger Pkinase_Tyr PF07714.17 PIK55622.1 - 1.2e-23 83.8 0.0 1.5e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK55622.1 - 1e-16 61.1 0.0 1.6e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain 7tm_2 PF00002.24 PIK55623.1 - 9.9e-39 133.1 24.4 1.3e-38 132.7 24.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK55623.1 - 1.2e-11 45.0 0.0 2.6e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK55623.1 - 5.4e-07 29.0 18.1 5.4e-07 29.0 18.1 1.3 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor ECSCR PF15820.5 PIK55623.1 - 0.056 13.3 0.1 0.056 13.3 0.1 3.3 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator FAM176 PF14851.6 PIK55623.1 - 0.14 11.8 1.9 4.1 7.1 0.0 3.1 3 0 0 3 3 3 0 FAM176 family DUF2149 PF09919.9 PIK55623.1 - 0.93 9.8 3.2 8.5 6.7 0.4 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2149) DUF2706 PF10913.8 PIK55624.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) Carn_acyltransf PF00755.20 PIK55625.1 - 2.8e-131 439.0 0.0 3.4e-131 438.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FAM35_C PF15793.5 PIK55625.1 - 0.31 10.4 1.4 1.5 8.2 0.5 2.1 2 0 0 2 2 2 0 Protein family FAM35, C-terminal Sulfotransfer_1 PF00685.27 PIK55626.1 - 7.7e-72 242.0 0.2 9e-72 241.7 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK55626.1 - 6.1e-11 43.1 1.5 4.3e-07 30.6 0.1 2.4 2 1 1 3 3 3 2 Sulfotransferase family UPF0300 PF08594.10 PIK55626.1 - 0.0054 16.1 0.0 0.009 15.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0300) Sulfotransfer_1 PF00685.27 PIK55627.1 - 3.1e-68 230.1 0.4 3.6e-68 229.9 0.4 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK55627.1 - 2.2e-09 38.0 0.1 8e-07 29.7 0.1 2.2 1 1 0 2 2 2 2 Sulfotransferase family CHGN PF05679.16 PIK55628.1 - 4.8e-143 477.7 0.1 5.9e-143 477.4 0.1 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase DUF4827 PF16109.5 PIK55628.1 - 0.07 13.1 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4827) Fringe PF02434.16 PIK55629.1 - 2.4e-11 43.6 0.1 4.7e-11 42.6 0.1 1.4 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 PIK55629.1 - 1.6e-05 24.8 0.2 0.024 14.4 0.0 2.3 1 1 1 2 2 2 2 Galactosyltransferase WD40 PF00400.32 PIK55631.1 - 3.4e-10 40.3 10.3 0.0074 17.1 0.4 7.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55631.1 - 0.019 15.2 0.5 14 6.0 0.0 4.4 6 1 0 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain Zona_pellucida PF00100.23 PIK55632.1 - 2e-42 145.8 5.1 3.7e-42 144.9 5.1 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain RVT_1 PF00078.27 PIK55633.1 - 9.6e-18 64.5 0.0 1.2e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK55635.1 - 2e-13 50.4 0.0 2.8e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK55636.1 - 2.1e-15 57.0 0.0 6.8e-15 55.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK55636.1 - 3.4e-05 23.5 0.0 9e-05 22.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 PIK55636.1 - 0.0062 17.0 0.0 0.025 15.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 PIK55636.1 - 0.024 14.0 0.0 0.053 12.9 0.0 1.5 1 0 0 1 1 1 0 KaiC DAP3 PF10236.9 PIK55636.1 - 0.034 13.3 0.0 0.075 12.2 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Zeta_toxin PF06414.12 PIK55636.1 - 0.092 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 PIK55636.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 PIK55636.1 - 0.16 11.3 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ZU5 PF00791.20 PIK55637.1 - 1.6e-15 57.2 0.0 2.7e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK55638.1 - 1.7e-14 53.7 2.2 2.6e-14 53.1 2.2 1.3 1 0 0 1 1 1 1 Death domain Rootletin PF15035.6 PIK55638.1 - 0.034 14.2 1.8 0.052 13.6 1.8 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GP24_25 PF17388.2 PIK55638.1 - 0.081 12.9 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 Arrestin_N PF00339.29 PIK55639.1 - 1.8e-37 128.6 0.2 2.3e-34 118.6 0.0 2.6 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 PIK55639.1 - 7e-26 91.3 0.6 1.7e-25 90.0 0.2 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain AP3B1_C PF14796.6 PIK55639.1 - 0.086 13.1 0.1 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal WD40 PF00400.32 PIK55640.1 - 2.4e-24 85.1 11.0 8.6e-05 23.2 0.0 6.4 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55640.1 - 6.5e-09 36.0 0.0 0.0033 17.7 0.0 4.5 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 PIK55640.1 - 0.00023 20.9 0.8 1.2 9.1 0.0 4.1 4 0 0 4 4 4 1 PQQ enzyme repeat DUF5046 PF16465.5 PIK55640.1 - 0.0065 16.0 0.5 1.9 7.8 0.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) PALB2_WD40 PF16756.5 PIK55640.1 - 0.011 14.8 0.8 0.55 9.1 0.0 3.4 3 2 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 PIK55640.1 - 0.13 10.9 0.5 6.9 5.2 0.1 3.2 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Atg14 PF10186.9 PIK55641.1 - 1.4e-17 63.7 5.8 2.3e-17 63.1 5.8 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 PIK55641.1 - 3.7e-05 22.8 13.9 0.013 14.4 0.1 3.1 2 1 1 3 3 3 2 Vacuolar protein sorting 38 APG6 PF04111.12 PIK55641.1 - 8.4e-05 22.6 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Apg6 BARA domain Jnk-SapK_ap_N PF09744.9 PIK55641.1 - 0.35 11.1 11.1 0.79 9.9 11.1 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0449 PF15136.6 PIK55641.1 - 0.97 9.9 9.2 0.71 10.4 5.7 2.6 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 RVT_1 PF00078.27 PIK55642.1 - 1.3e-35 123.0 0.1 1.5e-35 122.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SH3_9 PF14604.6 PIK55643.1 - 2e-08 34.0 0.0 3.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK55643.1 - 2.8e-08 33.3 0.1 6.1e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK55643.1 - 1.7e-06 27.6 0.0 3.1e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain zf-met PF12874.7 PIK55643.1 - 1.9e-05 24.9 0.1 3.5e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK55643.1 - 2.7e-05 24.3 0.2 6.8e-05 23.0 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding SH3_3 PF08239.11 PIK55643.1 - 0.0011 19.2 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain zf-C2H2_2 PF12756.7 PIK55643.1 - 0.0017 18.7 0.8 0.0049 17.2 0.2 1.9 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) RhoGEF PF00621.20 PIK55644.1 - 5.7e-37 127.7 4.0 1.2e-36 126.7 4.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 PIK55644.1 - 3.2e-29 101.5 0.5 1.5e-13 51.1 0.3 2.7 2 0 0 2 2 2 2 PH domain FERM_C PF09380.10 PIK55644.1 - 5.8e-23 81.1 0.1 2.4e-22 79.1 0.1 2.2 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK55644.1 - 3.7e-18 66.0 0.0 9.6e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 PIK55644.1 - 4e-09 36.3 0.0 1.2e-08 34.8 0.0 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.11 PIK55644.1 - 5.8e-08 32.7 1.8 1.5e-07 31.4 1.8 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) PH_13 PF16652.5 PIK55644.1 - 2e-07 30.9 0.3 0.0011 18.8 0.2 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 PIK55644.1 - 1.8e-05 24.7 0.0 7.3e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 PIK55644.1 - 0.0027 18.1 2.6 0.36 11.3 2.3 3.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 PIK55644.1 - 0.0087 16.3 0.1 0.54 10.6 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain H-kinase_dim PF02895.14 PIK55644.1 - 0.17 12.3 0.0 0.68 10.4 0.0 2.0 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain BLI1 PF17324.2 PIK55644.1 - 0.7 10.6 5.1 14 6.4 2.6 2.9 2 1 0 2 2 2 0 BLOC-1 interactor 1 DUF4298 PF14131.6 PIK55644.1 - 8.2 6.5 6.1 6.5 6.8 1.1 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4298) Cyclin_N PF00134.23 PIK55645.1 - 3.7e-13 49.3 1.0 5.5e-10 39.1 0.2 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 PIK55645.1 - 6.5e-09 36.1 0.1 1.5e-08 34.9 0.1 1.8 1 1 0 1 1 1 1 Cyclin C-terminal domain Cyclin_C PF02984.19 PIK55645.1 - 0.0043 17.1 0.2 0.0091 16.1 0.1 1.6 1 1 0 1 1 1 1 Cyclin, C-terminal domain Nro1 PF12753.7 PIK55645.1 - 0.12 11.3 0.2 0.2 10.6 0.2 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Gln-synt_C PF00120.24 PIK55646.1 - 1.9e-78 263.9 0.0 2.4e-78 263.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Esterase PF00756.20 PIK55647.1 - 3.2e-42 144.9 0.0 4e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 PIK55647.1 - 4.9e-05 22.4 0.0 7.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 PIK55647.1 - 0.0057 16.2 0.0 0.012 15.1 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 PIK55647.1 - 0.0079 14.9 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 PIK55647.1 - 0.016 14.5 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK55647.1 - 0.019 15.6 0.0 0.021 15.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 PIK55647.1 - 0.059 13.2 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 PIK55647.1 - 0.093 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase_phd PF10503.9 PIK55647.1 - 0.12 11.8 0.0 0.47 9.9 0.0 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase Chlorophyllase PF07224.11 PIK55647.1 - 0.16 11.0 0.0 0.51 9.3 0.0 1.7 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_3 PF07859.13 PIK55647.1 - 0.16 11.8 0.0 0.39 10.5 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold EGF PF00008.27 PIK55648.1 - 1.3e-17 63.7 60.2 3.5e-07 30.4 4.8 5.7 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 PIK55648.1 - 9.9e-07 29.2 38.5 0.002 18.7 1.5 6.6 5 1 0 5 5 5 3 Human growth factor-like EGF EGF_CA PF07645.15 PIK55648.1 - 0.017 15.3 8.7 0.017 15.3 8.7 5.9 4 1 1 5 5 5 0 Calcium-binding EGF domain Laminin_EGF PF00053.24 PIK55648.1 - 0.62 10.2 48.8 0.12 12.5 5.1 4.9 2 2 2 4 4 4 0 Laminin EGF domain EGF_3 PF12947.7 PIK55648.1 - 0.78 10.0 46.6 0.27 11.5 8.6 5.1 3 2 1 4 4 4 0 EGF domain L27_1 PF09058.10 PIK55649.1 - 7.3e-32 109.2 0.3 1.3e-31 108.3 0.3 1.5 1 0 0 1 1 1 1 L27_1 PDZ PF00595.24 PIK55649.1 - 8.6e-08 32.4 0.1 1.4e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 PDZ domain DHR-2 PF06920.13 PIK55650.1 - 1.7e-156 522.0 21.1 3.4e-156 521.0 21.1 1.5 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 PIK55650.1 - 2e-51 174.6 0.2 6.9e-51 172.8 0.1 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins PH PF00169.29 PIK55650.1 - 1.5e-10 41.5 0.2 7.2e-10 39.3 0.2 2.3 1 0 0 1 1 1 1 PH domain DUF3398 PF11878.8 PIK55650.1 - 3.8e-08 33.7 1.5 1.8e-07 31.6 0.9 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) TPR_7 PF13176.6 PIK55650.1 - 0.059 13.4 0.1 0.27 11.3 0.1 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat BTD PF09270.10 PIK55651.1 - 2.5e-24 86.3 0.0 5.7e-21 75.3 0.0 2.3 2 0 0 2 2 2 2 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 PIK55651.1 - 1e-09 39.2 0.1 2e-09 38.2 0.1 1.5 1 0 0 1 1 1 1 LAG1, DNA binding MINDY_DUB PF04424.13 PIK55652.1 - 5.1e-22 78.1 0.5 8e-13 48.4 0.1 2.4 1 1 1 2 2 2 2 MINDY deubiquitinase Phage_ABA_S PF18066.1 PIK55652.1 - 0.0031 18.2 0.0 0.0076 16.9 0.0 1.6 1 0 0 1 1 1 1 Phage ABA sandwich domain PHD PF00628.29 PIK55653.1 - 7.1e-09 35.4 6.7 1.3e-08 34.6 6.7 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK55653.1 - 1.4e-07 30.9 3.9 1.4e-07 30.9 3.9 1.8 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 PIK55653.1 - 0.0031 17.4 1.1 0.0031 17.4 1.1 1.9 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK55653.1 - 0.31 11.4 3.4 2.1 8.7 1.5 2.3 2 0 0 2 2 2 0 C1 domain zf-CSL PF05207.13 PIK55653.1 - 6.7 6.5 8.9 43 3.9 5.2 2.6 2 1 0 2 2 2 0 CSL zinc finger RepL PF05732.11 PIK55654.1 - 0.09 12.2 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) UXS1_N PF11803.8 PIK55654.1 - 0.19 12.1 0.1 0.37 11.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal NACHT PF05729.12 PIK55655.1 - 3.3e-13 49.9 0.0 6.8e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain WD40 PF00400.32 PIK55655.1 - 2.8e-10 40.6 1.3 5.3e-05 23.9 0.2 4.4 3 0 0 3 3 3 2 WD domain, G-beta repeat AAA_16 PF13191.6 PIK55655.1 - 1.4e-08 35.4 0.1 2.5e-07 31.2 0.0 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 PIK55655.1 - 5.5e-05 23.5 0.0 0.00021 21.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain DUF4062 PF13271.6 PIK55655.1 - 0.00016 22.0 0.0 0.00047 20.5 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) ANAPC4_WD40 PF12894.7 PIK55655.1 - 0.00036 20.8 0.0 2 8.8 0.0 4.4 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain ATPase_2 PF01637.18 PIK55655.1 - 0.00054 19.9 0.0 0.0018 18.3 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea APAF1_C PF17908.1 PIK55655.1 - 0.11 12.5 0.1 0.38 10.7 0.1 1.9 1 0 0 1 1 1 0 APAF-1 helical domain RsgA_GTPase PF03193.16 PIK55655.1 - 0.16 11.8 0.0 0.4 10.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Nup160 PF11715.8 PIK55655.1 - 0.21 10.2 7.0 6.2 5.3 0.1 4.2 3 1 2 5 5 5 0 Nucleoporin Nup120/160 7tm_1 PF00001.21 PIK55656.1 - 1.4e-54 185.2 18.9 5.7e-54 183.2 18.9 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK55656.1 - 5.1e-11 42.4 22.3 2.4e-08 33.7 15.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4711 PF15829.5 PIK55656.1 - 3e-05 24.1 0.1 5.4e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) 7TM_GPCR_Srx PF10328.9 PIK55656.1 - 4.1e-05 23.3 23.6 4.1e-05 23.3 23.6 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx EVI2A PF05399.11 PIK55656.1 - 0.043 13.4 1.1 0.16 11.5 0.1 2.2 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) DUF1676 PF07898.13 PIK55656.1 - 0.047 13.7 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DUF4448 PF14610.6 PIK55656.1 - 0.22 11.3 2.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF2207 PF09972.9 PIK55656.1 - 6 5.5 17.9 0.6 8.8 0.1 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF4407 PF14362.6 PIK55656.1 - 7.6 5.8 5.9 4 6.7 2.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) 7tm_1 PF00001.21 PIK55657.1 - 4.3e-46 157.4 2.4 5.5e-46 157.0 2.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55657.1 - 4.2e-08 33.1 15.0 4.2e-08 33.1 15.0 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55657.1 - 2e-06 27.4 8.4 2e-06 27.4 8.4 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.25 PIK55658.1 - 1.6e-66 224.4 0.0 2.4e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55658.1 - 9.8e-38 129.9 0.0 1.4e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 PIK55658.1 - 4.3e-24 84.5 0.2 4.6e-21 74.8 0.1 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 PIK55658.1 - 5.2e-05 22.7 0.0 8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK55658.1 - 0.00032 19.6 0.0 0.00052 18.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK55658.1 - 0.016 14.6 0.2 0.048 13.0 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK55658.1 - 0.027 13.4 0.1 0.051 12.5 0.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain G-patch PF01585.23 PIK55659.1 - 2.5e-12 46.5 1.2 4.5e-12 45.7 1.2 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK55659.1 - 0.00062 19.8 1.6 0.00062 19.8 1.6 2.1 2 0 0 2 2 2 1 G-patch domain DUF1647 PF07801.11 PIK55660.1 - 5.3e-20 71.6 0.0 1e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) GST_C_4 PF14834.6 PIK55660.1 - 0.1 13.0 0.0 0.25 11.7 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Gal-3-0_sulfotr PF06990.11 PIK55661.1 - 3.9e-39 134.7 1.3 5.2e-39 134.3 1.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK55661.1 - 0.0055 17.1 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK55661.1 - 0.074 12.9 2.1 0.56 10.1 2.1 2.1 1 1 0 1 1 1 0 Sulfotransferase family T3SS_ExsE PF18286.1 PIK55664.1 - 0.0022 17.9 2.6 62 3.6 0.0 4.3 4 0 0 4 4 4 0 Type III secretion system ExsE Psb28 PF03912.14 PIK55664.1 - 0.0058 16.9 7.2 15 5.9 0.0 4.7 5 0 0 5 5 5 1 Psb28 protein DUF2957 PF11170.8 PIK55664.1 - 0.028 13.3 0.5 80 1.9 0.0 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF2957) T6SS-SciN PF12790.7 PIK55664.1 - 0.03 14.0 7.1 41 3.9 0.0 5.2 6 0 0 6 6 6 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 Rrp44_CSD1 PF17216.3 PIK55664.1 - 0.21 11.3 8.9 31 4.2 0.1 4.1 4 0 0 4 4 4 0 Rrp44-like cold shock domain LZ_Tnp_IS66 PF13007.7 PIK55664.1 - 0.65 10.8 7.4 1.4e+02 3.4 0.1 4.2 4 0 0 4 4 4 0 Transposase C of IS166 homeodomain FAM220 PF15487.6 PIK55664.1 - 0.99 9.0 28.4 3.3 7.3 3.2 4.3 1 1 3 4 4 4 0 FAM220 family DUF281 PF03436.13 PIK55664.1 - 3 8.3 10.5 1.5e+02 2.8 0.1 5.4 5 3 0 5 5 5 0 Domain of unknown function (DUF281) Secretin PF00263.21 PIK55664.1 - 5.3 6.6 8.3 1.1e+02 2.4 0.1 4.0 4 0 0 4 4 4 0 Bacterial type II and III secretion system protein Pkinase_Tyr PF07714.17 PIK55666.1 - 9.1e-19 67.7 0.0 1.1e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK55666.1 - 5.9e-18 65.2 0.0 8.5e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain YorP PF09629.10 PIK55666.1 - 0.032 14.4 0.0 4.1 7.7 0.0 2.3 2 0 0 2 2 2 0 YorP protein RVT_1 PF00078.27 PIK55667.1 - 6.3e-26 91.3 0.1 7.4e-26 91.0 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 PIK55668.1 - 0.2 12.6 6.5 0.76 10.8 2.1 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger NHL PF01436.21 PIK55670.1 - 2.1e-10 40.1 8.5 0.023 14.7 0.0 6.1 6 0 0 6 6 6 3 NHL repeat Filamin PF00630.19 PIK55670.1 - 6.2e-06 27.0 0.2 0.0001 23.0 0.0 2.4 2 0 0 2 2 2 1 Filamin/ABP280 repeat SGL PF08450.12 PIK55670.1 - 0.00093 18.8 0.0 0.46 10.0 0.0 3.4 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 PIK55670.1 - 0.0025 17.7 2.0 1.6 8.8 0.1 2.8 3 0 0 3 3 3 2 Beta-propeller repeat Lactonase PF10282.9 PIK55670.1 - 0.0089 15.3 0.3 0.24 10.6 0.0 2.4 2 1 1 3 3 3 2 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 PIK55670.1 - 0.099 13.0 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Aldo_ket_red PF00248.21 PIK55671.1 - 2e-16 60.1 0.0 3.7e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 PIK55672.1 - 2.1e-06 27.2 0.0 2.5e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RVT_1 PF00078.27 PIK55673.1 - 1.1e-08 34.9 0.0 1.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HisK_sensor PF18698.1 PIK55674.1 - 0.0099 16.3 0.1 3.7 7.9 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase sensor domain C2-set_2 PF08205.12 PIK55674.1 - 0.016 15.2 6.0 12 6.0 0.1 4.4 3 2 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Peptidase_S58 PF03576.14 PIK55674.1 - 0.056 13.0 0.0 4.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S58 Y1_Tnp PF01797.16 PIK55674.1 - 2.6 8.2 7.0 6.1 7.0 1.2 2.7 2 0 0 2 2 2 0 Transposase IS200 like DUF1272 PF06906.11 PIK55674.1 - 2.9 8.1 5.3 16 5.7 1.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) Inhibitor_I67 PF11405.8 PIK55675.1 - 0.0091 16.2 1.0 8.1 6.8 0.1 3.0 2 0 0 2 2 2 2 Bromelain inhibitor VI DUF4359 PF14271.6 PIK55675.1 - 0.065 14.0 0.1 30 5.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) Myb_DNA-bind_4 PF13837.6 PIK55676.1 - 0.00029 21.2 0.9 0.00029 21.2 0.9 2.7 2 1 1 3 3 3 1 Myb/SANT-like DNA-binding domain V-set PF07686.17 PIK55677.1 - 0.00028 21.0 1.4 0.0012 19.0 0.5 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain MBG PF17883.1 PIK55677.1 - 0.018 15.6 0.3 0.047 14.3 0.2 1.7 2 0 0 2 2 2 0 MBG domain Ig_3 PF13927.6 PIK55677.1 - 0.056 14.0 1.4 2.4 8.8 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Clathrin_propel PF01394.20 PIK55677.1 - 0.076 13.4 0.9 7.5 7.1 0.1 2.4 2 0 0 2 2 2 0 Clathrin propeller repeat Ig_C17orf99 PF17736.1 PIK55677.1 - 0.088 12.8 0.2 0.47 10.5 0.0 2.1 1 1 1 2 2 2 0 C17orf99 Ig domain I-set PF07679.16 PIK55677.1 - 0.09 12.9 0.1 0.84 9.7 0.0 2.6 3 1 0 3 3 3 0 Immunoglobulin I-set domain zf-CCHC PF00098.23 PIK55678.1 - 8.6e-06 25.6 16.1 0.0024 17.9 3.3 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55678.1 - 3.2e-05 23.6 6.2 0.0022 17.8 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK55678.1 - 0.00013 21.7 14.3 0.36 10.6 1.1 3.3 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK55678.1 - 0.93 9.8 12.2 0.37 11.0 6.8 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_10 PF16685.5 PIK55679.1 - 2.1 8.6 4.8 1 9.5 1.2 2.3 1 1 1 2 2 2 0 zinc RING finger of MSL2 RVT_1 PF00078.27 PIK55680.1 - 1.1e-05 25.1 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) QueH PF02677.14 PIK55680.1 - 0.017 15.2 2.1 0.017 15.2 2.1 2.1 2 1 1 3 3 3 0 Epoxyqueuosine reductase QueH Exo_endo_phos_2 PF14529.6 PIK55680.1 - 0.08 12.8 0.5 4.3 7.2 0.1 3.1 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase Ribosomal_L34e PF01199.18 PIK55680.1 - 0.17 12.2 4.2 0.38 11.1 4.2 1.6 1 0 0 1 1 1 0 Ribosomal protein L34e C2-set_2 PF08205.12 PIK55682.1 - 0.044 13.8 0.3 3.4 7.8 0.1 2.9 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain HTH_36 PF13730.6 PIK55682.1 - 0.059 13.3 0.1 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain V-set PF07686.17 PIK55682.1 - 0.067 13.4 0.0 0.23 11.6 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin V-set domain Peptidase_S58 PF03576.14 PIK55682.1 - 0.069 12.7 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S58 UFC1 PF08694.11 PIK55682.1 - 0.35 10.5 2.1 1.2 8.8 0.0 2.8 5 0 0 5 5 5 0 Ubiquitin-fold modifier-conjugating enzyme 1 zf-CCHC_2 PF13696.6 PIK55683.1 - 2.5e-05 24.0 5.2 0.0036 17.1 0.1 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK55683.1 - 0.0002 21.0 13.9 0.35 10.6 1.1 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 PIK55683.1 - 0.00021 21.2 17.0 0.0024 17.9 3.3 3.8 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK55683.1 - 4.1 7.7 16.1 0.24 11.6 7.3 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Mic1 PF07035.12 PIK55685.1 - 1.2e-05 25.0 0.6 0.00024 20.9 0.1 2.2 2 0 0 2 2 2 2 Colon cancer-associated protein Mic1-like ANAPC4_WD40 PF12894.7 PIK55686.1 - 0.11 12.8 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Annexin PF00191.20 PIK55687.1 - 6.4e-71 234.4 11.6 1.7e-23 82.4 0.5 5.1 4 1 1 5 5 5 5 Annexin UBA_2 PF08587.11 PIK55687.1 - 0.082 13.0 0.4 8.8 6.5 0.1 3.0 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Annexin PF00191.20 PIK55688.1 - 2.4e-39 133.2 3.6 8.8e-18 64.1 0.1 4.6 4 1 0 4 4 4 4 Annexin Fibrinogen_C PF00147.18 PIK55689.1 - 3.1e-54 184.1 7.1 3.6e-54 183.9 7.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain C6 PF01681.17 PIK55689.1 - 0.088 13.3 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 C6 domain Doppel PF11466.8 PIK55689.1 - 0.45 10.2 0.1 0.45 10.2 0.1 1.5 2 0 0 2 2 2 0 Prion-like protein Doppel Annexin PF00191.20 PIK55690.1 - 2.2e-88 290.3 10.3 3.2e-25 88.0 0.1 4.0 3 1 1 4 4 4 4 Annexin Acetyltransf_11 PF13720.6 PIK55690.1 - 0.018 15.5 0.3 1.3 9.6 0.1 3.1 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 UBA_2 PF08587.11 PIK55690.1 - 0.057 13.5 0.1 5.4 7.2 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin associated domain (UBA) CMD PF02627.20 PIK55690.1 - 0.06 13.4 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Annexin PF00191.20 PIK55691.1 - 5.9e-68 224.9 6.1 1.5e-22 79.4 0.2 4.2 4 0 0 4 4 4 4 Annexin HSCB_C PF07743.13 PIK55691.1 - 8.9 6.9 8.8 1.3 9.6 0.7 2.8 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain IFT43 PF15305.6 PIK55692.1 - 2 8.6 0.0 2 8.6 0.0 2.7 3 1 0 3 3 3 0 Intraflagellar transport protein 43 Shadoo PF14999.6 PIK55692.1 - 6.2 6.9 12.1 0.21 11.7 3.0 2.9 2 1 1 3 3 3 0 Shadow of prion protein, neuroprotective DUF2939 PF11159.8 PIK55692.1 - 7.4 7.1 6.4 3.3 8.2 1.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2939) Fibrinogen_C PF00147.18 PIK55694.1 - 9.6e-29 100.8 0.1 2.1e-26 93.1 0.2 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55694.1 - 1.1e-09 38.1 5.2 1.1e-09 38.1 5.2 3.1 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK55694.1 - 5.9e-07 29.6 10.8 5.9e-07 29.6 10.8 4.1 3 1 1 4 4 4 2 EGF domain cEGF PF12662.7 PIK55694.1 - 0.081 12.9 20.0 0.12 12.3 0.3 4.3 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK55694.1 - 4.3 7.5 20.1 0.82 9.8 7.4 3.2 3 0 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK55695.1 - 6.3e-16 58.8 3.1 5e-15 55.9 3.1 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK55696.1 - 5e-45 154.0 17.2 1.2e-44 152.8 17.2 1.6 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain NADH-G_4Fe-4S_3 PF10588.9 PIK55696.1 - 2.3 7.8 5.7 14 5.3 2.6 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fibrinogen_C PF00147.18 PIK55697.1 - 1.1e-69 234.7 2.9 2.4e-34 119.1 0.2 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55697.1 - 2e-07 30.8 7.4 2e-07 30.8 7.4 3.5 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK55697.1 - 0.00079 19.6 11.8 0.00079 19.6 11.8 4.3 4 1 1 5 5 5 2 EGF domain Fibrinogen_C PF00147.18 PIK55698.1 - 2.6e-51 174.5 7.3 3e-51 174.3 7.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK55699.1 - 4.5e-41 141.1 2.2 9.2e-41 140.1 2.1 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF3747 PF12565.8 PIK55699.1 - 0.21 10.9 2.5 0.67 9.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3747) Fibrinogen_C PF00147.18 PIK55700.1 - 2.6e-16 60.1 5.1 6.1e-16 58.9 5.1 1.8 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK55701.1 - 1.7e-37 129.4 0.2 1.1e-34 120.2 0.4 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55701.1 - 1.4e-07 31.4 7.5 1.4e-07 31.4 7.5 3.5 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK55701.1 - 0.00054 20.1 11.8 0.00054 20.1 11.8 4.3 4 1 1 5 5 5 1 EGF domain cEGF PF12662.7 PIK55701.1 - 0.16 11.9 0.5 0.16 11.9 0.5 5.0 4 1 0 4 4 4 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK55702.1 - 2.2e-29 102.9 1.2 1.7e-25 90.1 1.7 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55702.1 - 9.5e-06 25.5 2.4 9.5e-06 25.5 2.4 3.0 1 1 2 3 3 3 1 TILa domain Fibrinogen_C PF00147.18 PIK55703.1 - 8e-48 163.1 4.3 4e-44 151.0 6.1 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55703.1 - 1.3e-07 31.5 5.3 1.3e-07 31.5 5.3 3.0 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK55703.1 - 4.4e-06 26.8 9.6 4.4e-06 26.8 9.6 4.3 3 1 1 4 4 4 1 EGF domain cEGF PF12662.7 PIK55703.1 - 0.16 12.0 23.4 0.16 11.9 0.4 4.5 3 1 0 3 3 3 0 Complement Clr-like EGF-like SH2 PF00017.24 PIK55704.1 - 2e-21 75.9 0.1 3.2e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK55704.1 - 4.6e-14 51.7 0.1 8.4e-14 50.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK55704.1 - 1.8e-10 40.5 0.1 4.2e-10 39.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK55704.1 - 4.9e-08 32.5 0.0 1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH2_2 PF14633.6 PIK55704.1 - 0.00022 20.7 0.1 0.0062 16.0 0.1 2.1 2 0 0 2 2 2 1 SH2 domain PPR_2 PF13041.6 PIK55705.1 - 2.3e-36 123.8 5.6 5.6e-12 45.7 0.1 6.9 5 2 2 7 7 7 6 PPR repeat family PPR_3 PF13812.6 PIK55705.1 - 9.1e-27 92.9 8.3 8.2e-07 29.0 0.1 6.8 5 1 2 7 7 7 5 Pentatricopeptide repeat domain PPR_long PF17177.4 PIK55705.1 - 1.1e-17 64.1 0.0 1.8e-09 37.3 0.0 4.5 2 2 3 5 5 5 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 PIK55705.1 - 4.3e-15 55.1 0.1 0.0033 17.1 0.0 7.8 8 0 0 8 8 8 2 PPR repeat PPR PF01535.20 PIK55705.1 - 4.4e-14 51.6 12.2 2.1e-05 24.4 0.1 6.9 8 0 0 8 8 8 3 PPR repeat Exog_C PF18026.1 PIK55705.1 - 0.037 14.1 0.5 10 6.3 0.0 4.1 4 0 0 4 4 4 0 Endo/exonuclease (EXOG) C-terminal domain G-alpha PF00503.20 PIK55706.1 - 1.8e-13 50.4 0.1 2.2e-13 50.1 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK55706.1 - 0.0022 17.5 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF815 PF05673.13 PIK55706.1 - 0.0048 16.1 0.0 0.0049 16.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 PIK55706.1 - 0.016 15.0 0.1 0.021 14.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 PIK55706.1 - 0.016 15.6 0.0 0.019 15.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.9 PIK55706.1 - 0.031 13.5 0.2 0.034 13.3 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.6 PIK55706.1 - 0.034 13.9 0.1 0.045 13.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 PIK55706.1 - 0.061 13.5 0.1 0.09 13.0 0.1 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 PIK55706.1 - 0.064 12.6 0.3 0.077 12.3 0.3 1.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family TniB PF05621.11 PIK55706.1 - 0.065 12.6 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 PIK55707.1 - 1.3e-69 235.0 0.1 1.6e-69 234.7 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK55707.1 - 8.2e-09 35.1 0.0 1.7e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK55707.1 - 0.003 16.9 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK55707.1 - 0.054 13.0 0.0 0.078 12.5 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MARVEL PF01284.23 PIK55708.1 - 1.9e-12 47.5 15.8 2.5e-12 47.1 15.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain UPF0014 PF03649.13 PIK55708.1 - 0.036 13.4 1.3 0.056 12.8 1.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) DctQ PF04290.12 PIK55708.1 - 0.23 11.4 7.1 6 6.8 2.3 2.3 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component zf-C2H2_4 PF13894.6 PIK55709.1 - 0.012 16.4 0.3 0.012 16.4 0.3 7.3 7 1 0 7 7 7 0 C2H2-type zinc finger zf-ACC PF17848.1 PIK55709.1 - 0.026 14.6 0.1 0.026 14.6 0.1 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2 PF00096.26 PIK55709.1 - 0.029 14.8 0.7 0.029 14.8 0.7 6.9 8 1 0 8 8 8 0 Zinc finger, C2H2 type A2L_zn_ribbon PF08792.10 PIK55709.1 - 0.98 9.2 5.3 2.3 8.0 0.0 3.4 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-piccolo PF05715.13 PIK55709.1 - 1.6 8.9 6.0 6 7.1 0.2 3.4 3 0 0 3 3 3 0 Piccolo Zn-finger DUF4187 PF13821.6 PIK55709.1 - 9 6.2 14.0 0.1 12.4 2.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4187) Glyco_transf_10 PF00852.19 PIK55711.1 - 1.8e-22 79.9 0.0 3.5e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK55711.1 - 1.1e-05 25.9 0.2 2e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal 7tm_1 PF00001.21 PIK55712.1 - 2.2e-26 92.8 4.8 2.7e-26 92.5 4.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK55712.1 - 2.9e-09 36.7 7.2 2.9e-09 36.7 7.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK55712.1 - 0.00056 19.6 6.4 0.00056 19.6 6.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Shisa PF13908.6 PIK55712.1 - 2.6 8.2 4.6 1.6 9.0 0.1 2.5 2 2 0 2 2 2 0 Wnt and FGF inhibitory regulator 7TM_GPCR_Srab PF10292.9 PIK55712.1 - 6.3 5.6 13.2 0.016 14.1 3.5 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor 7tm_1 PF00001.21 PIK55713.1 - 2.6e-23 82.7 5.2 3.7e-23 82.2 5.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK55713.1 - 5.8e-09 35.7 7.1 5.8e-09 35.7 7.1 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK55713.1 - 0.00021 21.0 6.5 0.00021 21.0 6.5 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srab PF10292.9 PIK55713.1 - 0.0076 15.2 3.2 0.014 14.4 3.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR receptor class ab chemoreceptor Erg28 PF03694.13 PIK55713.1 - 0.016 15.6 0.5 7.8 6.9 0.1 3.3 2 1 0 3 3 3 0 Erg28 like protein 7TM_GPCR_Srbc PF10316.9 PIK55713.1 - 0.018 14.5 9.9 0.04 13.4 9.9 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc Shisa PF13908.6 PIK55713.1 - 6.3 7.0 7.1 1.6 8.9 0.1 2.8 1 1 2 3 3 3 0 Wnt and FGF inhibitory regulator Pkinase PF00069.25 PIK55714.1 - 3.9e-27 95.3 0.0 5e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55714.1 - 5.3e-17 62.0 0.0 6.4e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK55714.1 - 1.6e-09 37.1 0.0 2.4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK55714.1 - 0.00029 20.8 0.1 0.0009 19.2 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK55714.1 - 0.021 13.8 0.2 0.037 13.0 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 PIK55714.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sirohm_synth_C PF14823.6 PIK55715.1 - 0.13 11.9 0.0 0.39 10.4 0.0 1.8 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal E1-E2_ATPase PF00122.20 PIK55716.1 - 0.00031 20.3 0.4 0.013 15.0 0.0 2.2 2 0 0 2 2 2 2 E1-E2 ATPase HTH_48 PF17906.1 PIK55716.1 - 0.021 14.9 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 HTH domain in Mos1 transposase CN_hydrolase PF00795.22 PIK55717.1 - 1.5e-12 47.5 0.0 1.9e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CAP-ZIP_m PF15255.6 PIK55719.1 - 5.4e-10 39.7 18.0 8.9e-06 26.0 2.1 4.3 2 1 1 3 3 3 2 WASH complex subunit CAP-Z interacting, central region Chisel PF15355.6 PIK55719.1 - 0.0021 18.3 0.4 0.0021 18.3 0.4 6.5 7 0 0 7 7 7 1 Stretch-responsive small skeletal muscle X protein, Chisel Nucleoporin_FG PF13634.6 PIK55719.1 - 6.2 7.8 76.0 0.26 12.2 6.0 11.8 4 2 2 8 8 8 0 Nucleoporin FG repeat region Nuf2 PF03800.14 PIK55720.1 - 3.4e-32 111.5 0.6 3.4e-32 111.5 0.6 3.4 4 0 0 4 4 4 1 Nuf2 family DHR10 PF18595.1 PIK55720.1 - 0.00017 21.6 15.3 0.00017 21.6 15.3 3.5 1 1 2 3 3 3 3 Designed helical repeat protein 10 domain RNase_T PF00929.24 PIK55721.1 - 2.3e-24 86.8 0.0 3.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease IQCJ-SCHIP1 PF15157.6 PIK55721.1 - 0.037 13.9 0.2 0.067 13.0 0.2 1.3 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif DUF5051 PF16473.5 PIK55721.1 - 0.099 12.6 0.1 0.22 11.5 0.1 1.7 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like TspO_MBR PF03073.15 PIK55722.1 - 7.3e-09 35.8 10.0 1.1e-08 35.2 9.5 1.6 1 1 1 2 2 2 1 TspO/MBR family DUF1482 PF07358.11 PIK55722.1 - 0.29 11.1 1.6 0.7 9.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1482) DUF2202 PF09968.9 PIK55723.1 - 0.013 15.4 1.2 0.033 14.0 0.2 2.0 2 1 0 2 2 2 0 Uncharacterized protein domain (DUF2202) Potass_KdpF PF09604.10 PIK55723.1 - 1.3 9.1 2.9 2 8.5 2.9 1.3 1 0 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) GBP PF02263.19 PIK55724.1 - 9.4e-37 126.7 0.0 1.1e-36 126.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain UNC-93 PF05978.16 PIK55725.1 - 5.4e-24 84.7 0.2 5.4e-24 84.7 0.2 2.9 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 PIK55725.1 - 1.5e-11 43.9 27.4 4e-08 32.6 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PLDc_2 PF13091.6 PIK55726.1 - 3.2e-27 95.0 0.0 4.4e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 PIK55726.1 - 9.8e-05 22.4 0.1 9.8e-05 22.4 0.1 1.9 2 0 0 2 2 2 1 Phospholipase D Active site motif FAM83 PF07894.12 PIK55726.1 - 0.00017 21.2 0.1 0.00056 19.5 0.0 1.7 1 1 1 2 2 2 1 FAM83 A-H DUF4022 PF13214.6 PIK55726.1 - 0.0051 17.0 1.0 0.012 15.9 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4022) RT_RNaseH_2 PF17919.1 PIK55727.1 - 7.6e-29 99.7 0.0 1.9e-28 98.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55727.1 - 3.6e-27 94.7 0.0 7.8e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK55727.1 - 1.7e-21 76.6 0.0 3.6e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK55727.1 - 8e-19 67.5 0.6 1.7e-18 66.5 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK55727.1 - 2e-06 27.9 0.1 5.6e-06 26.5 0.1 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK55727.1 - 0.0038 17.0 0.0 0.0098 15.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK55727.1 - 0.018 15.3 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 DDE domain BCNT PF07572.12 PIK55727.1 - 0.16 12.0 0.1 0.35 11.0 0.1 1.5 1 0 0 1 1 1 0 Bucentaur or craniofacial development RVT_1 PF00078.27 PIK55728.1 - 1.3e-27 96.8 0.0 2e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4722 PF15849.5 PIK55728.1 - 0.0021 17.8 0.0 0.0041 16.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4722) gag-asp_proteas PF13975.6 PIK55728.1 - 0.11 13.1 0.0 0.54 10.8 0.0 2.2 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease CRISPR_Cse2 PF09485.10 PIK55728.1 - 0.13 12.8 0.7 23 5.5 0.2 2.5 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) HJURP_C PF12347.8 PIK55728.1 - 0.15 12.1 0.0 21 5.2 0.0 2.6 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat PIP5K PF01504.18 PIK55729.1 - 2.4e-46 158.2 1.8 2.9e-38 131.7 1.4 2.8 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 PIK55729.1 - 2.2e-21 76.1 0.1 3.8e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DEP PF00610.21 PIK55729.1 - 0.0042 17.1 0.0 0.014 15.5 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Selenoprotein_S PF06936.11 PIK55729.1 - 0.04 13.7 6.0 0.1 12.4 1.1 2.6 2 0 0 2 2 2 0 Selenoprotein S (SelS) EF-hand_1 PF00036.32 PIK55730.1 - 3.7e-11 41.7 1.3 1.8e-06 27.1 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK55730.1 - 1.7e-10 40.0 0.9 7.2e-06 25.5 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 PIK55730.1 - 5.6e-10 39.5 1.2 6.1e-08 33.0 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK55730.1 - 2.3e-08 33.1 0.3 9.3e-06 24.9 0.0 3.7 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 PIK55730.1 - 7e-08 32.2 1.1 0.29 11.0 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair DUF5580 PF17743.1 PIK55730.1 - 0.00022 19.9 0.0 0.00039 19.1 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 PIK55730.1 - 0.014 15.3 0.4 0.17 11.8 0.1 2.5 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK55730.1 - 0.016 15.5 0.1 0.066 13.5 0.0 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4483 PF14825.6 PIK55730.1 - 0.028 14.2 0.2 8 6.2 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4483) Guanylate_cyc PF00211.20 PIK55731.1 - 5.4e-36 123.9 0.5 5e-19 68.6 0.0 3.0 2 1 1 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 PIK55731.1 - 2.1e-10 40.3 0.0 4.3e-10 39.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK55731.1 - 1.5e-06 27.8 0.0 2.8e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 PIK55731.1 - 0.00073 19.0 2.5 0.0012 18.3 2.5 1.3 1 0 0 1 1 1 1 Heme NO binding associated MitMem_reg PF13012.6 PIK55731.1 - 0.025 15.0 0.1 0.059 13.8 0.1 1.6 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Lipase PF00151.19 PIK55732.1 - 3.3e-38 131.8 1.5 4.9e-38 131.3 1.5 1.2 1 0 0 1 1 1 1 Lipase Fibrinogen_C PF00147.18 PIK55733.1 - 2e-33 116.0 11.2 4.7e-33 114.8 11.2 1.7 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain MVL PF12151.8 PIK55733.1 - 0.039 13.8 0.7 0.08 12.8 0.7 1.5 1 0 0 1 1 1 0 Mannan-binding protein Nse4_C PF08743.10 PIK55734.1 - 3.5e-22 78.5 0.1 9e-22 77.2 0.1 1.7 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 PIK55734.1 - 2.4e-05 24.3 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Peptidase_S8 PF00082.22 PIK55735.1 - 9.5e-40 136.7 4.3 1.4e-39 136.1 4.3 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK55735.1 - 0.00095 19.8 0.0 0.0017 19.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Dynactin PF12455.8 PIK55736.1 - 2e-72 243.9 8.2 2e-72 243.9 8.2 5.1 4 2 1 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 PIK55736.1 - 9e-21 73.7 0.6 1.9e-20 72.6 0.6 1.6 1 0 0 1 1 1 1 CAP-Gly domain Trimer_CC PF08954.11 PIK55736.1 - 0.0046 16.5 0.0 0.0046 16.5 0.0 5.3 5 0 0 5 5 5 1 Trimerisation motif PCYCGC PF13798.6 PIK55736.1 - 1.1 9.1 8.7 0.42 10.4 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function with PCYCGC motif NRBF2_MIT PF17169.4 PIK55737.1 - 0.0011 19.1 2.1 0.0011 19.1 2.1 2.1 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 Vac_Fusion PF02346.16 PIK55737.1 - 0.059 13.0 2.1 0.14 11.8 2.1 1.7 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 LAGLIDADG_2 PF03161.13 PIK55737.1 - 0.061 13.3 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family Uso1_p115_C PF04871.13 PIK55737.1 - 0.87 10.0 24.7 0.067 13.6 4.4 2.7 3 1 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region UPF0242 PF06785.11 PIK55737.1 - 1.4 9.0 18.2 0.3 11.1 7.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlxA PF14282.6 PIK55737.1 - 2 8.4 12.4 6.5 6.8 2.6 2.7 2 1 0 2 2 2 0 FlxA-like protein Hydrolase_3 PF08282.12 PIK55737.1 - 2.2 7.9 6.0 2.4 7.8 1.6 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Rrp15p PF07890.12 PIK55737.1 - 2.2 8.6 20.0 0.24 11.7 8.0 2.6 2 1 0 2 2 2 0 Rrp15p Kelch_4 PF13418.6 PIK55738.1 - 7.9e-34 115.4 1.8 7.4e-08 32.3 0.0 6.6 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK55738.1 - 4e-31 106.5 4.6 1.7e-06 27.8 0.0 7.1 7 0 0 7 7 7 6 Kelch motif Kelch_3 PF13415.6 PIK55738.1 - 8.7e-30 102.4 4.2 2.7e-07 30.7 0.1 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK55738.1 - 1.9e-27 94.2 1.2 0.00028 20.7 0.0 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 PIK55738.1 - 9.4e-24 82.7 3.8 7.8e-06 25.4 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 PIK55738.1 - 1.8e-22 78.8 3.2 0.00019 21.6 0.0 5.5 2 2 3 5 5 5 5 Kelch motif US10 PF17617.2 PIK55738.1 - 0.094 12.8 0.0 19 5.3 0.0 2.3 2 0 0 2 2 2 0 Viral unique short region 10 Glyco_transf_7C PF02709.14 PIK55740.1 - 1.3e-25 88.8 0.1 2.8e-25 87.8 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 PIK55740.1 - 1.7e-24 85.9 0.6 2.6e-24 85.4 0.6 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_2 PF10111.9 PIK55740.1 - 0.013 14.9 0.2 0.83 9.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 RGP PF03214.13 PIK55740.1 - 0.051 12.7 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Reversibly glycosylated polypeptide FTCD_C PF04961.12 PIK55740.1 - 0.096 12.5 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase TPR_1 PF00515.28 PIK55741.1 - 2.8e-17 61.7 8.8 3e-08 33.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK55741.1 - 2.9e-15 55.1 6.2 4.4e-06 26.4 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55741.1 - 5.1e-10 38.9 0.8 0.0012 18.5 0.1 3.3 2 1 1 3 3 3 2 TPR repeat TPR_12 PF13424.6 PIK55741.1 - 5.4e-10 39.4 5.9 4.4e-07 30.1 2.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55741.1 - 3.5e-07 29.9 0.6 0.00018 21.5 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55741.1 - 9.8e-05 22.9 0.5 0.014 16.0 0.2 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK55741.1 - 0.00029 20.9 2.6 0.00071 19.7 2.2 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK55741.1 - 0.0006 19.1 2.6 0.0057 15.9 0.4 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55741.1 - 0.0016 19.1 2.7 0.043 14.6 1.4 3.0 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK55741.1 - 0.0057 16.9 0.2 0.56 10.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55741.1 - 0.015 15.8 2.0 0.046 14.2 1.1 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK55741.1 - 0.024 14.1 1.5 3.7 7.1 0.1 3.8 3 0 0 3 3 3 0 SHNi-TPR SesA PF17107.5 PIK55741.1 - 0.041 14.1 0.6 0.041 14.1 0.6 3.0 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_6 PF13174.6 PIK55741.1 - 0.15 12.7 1.4 0.71 10.6 0.4 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK55741.1 - 0.29 11.3 3.2 0.24 11.5 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 PIK55741.1 - 5.8 7.1 12.0 2.3 8.4 0.3 3.7 3 2 1 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 PIK55742.1 - 5.8e-08 32.9 9.3 0.00031 21.0 1.6 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK55742.1 - 6e-05 22.8 8.8 9.8 6.6 0.2 7.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55742.1 - 0.029 15.2 5.3 2.1 9.4 1.3 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55742.1 - 0.067 13.7 9.8 0.49 10.9 0.1 6.1 8 0 0 8 8 8 0 Tetratricopeptide repeat IcmF-related PF06761.12 PIK55742.1 - 0.094 12.2 5.2 3 7.2 0.0 3.1 3 0 0 3 3 3 0 Intracellular multiplication and human macrophage-killing Baculo_PEP_C PF04513.12 PIK55742.1 - 0.15 12.1 2.1 6.4 6.8 0.1 4.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2225 PF09986.9 PIK55742.1 - 0.52 10.0 5.5 0.86 9.3 0.1 3.5 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF4094 PF13334.6 PIK55742.1 - 0.92 10.0 3.9 7.4 7.1 0.1 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) TPR_8 PF13181.6 PIK55742.1 - 0.98 9.8 13.5 28 5.3 0.0 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat Med18 PF09637.10 PIK55743.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Med18 protein GCFC PF07842.12 PIK55743.1 - 0.063 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein Prominin PF05478.11 PIK55744.1 - 3.1e-90 303.3 0.5 4.1e-90 302.9 0.5 1.0 1 0 0 1 1 1 1 Prominin CitMHS PF03600.16 PIK55744.1 - 0.00017 20.9 0.3 0.0014 17.9 0.0 2.3 2 1 0 2 2 2 1 Citrate transporter TRP PF06011.12 PIK55744.1 - 0.00064 18.6 4.2 0.015 14.1 0.7 2.2 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel Baculo_PEP_C PF04513.12 PIK55744.1 - 0.004 17.2 10.0 0.84 9.7 0.3 4.5 4 0 0 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus REF PF05755.12 PIK55744.1 - 0.19 11.5 0.3 0.79 9.5 0.0 2.1 3 0 0 3 3 3 0 Rubber elongation factor protein (REF) MtrB PF05440.12 PIK55744.1 - 0.44 11.0 0.1 0.44 11.0 0.1 3.2 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B Shisa PF13908.6 PIK55744.1 - 4.6 7.4 7.3 23 5.2 1.5 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF898 PF05987.13 PIK55744.1 - 5.7 5.9 6.3 15 4.5 0.9 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF2207 PF09972.9 PIK55744.1 - 9 4.9 10.9 40 2.8 0.0 3.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Prominin PF05478.11 PIK55745.1 - 5.6e-21 74.2 0.4 6.6e-21 74.0 0.4 1.0 1 0 0 1 1 1 1 Prominin BNR_2 PF13088.6 PIK55746.1 - 5.6e-11 42.3 0.0 1.7e-10 40.7 0.0 1.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK55746.1 - 0.0022 17.7 1.4 1 9.6 0.3 3.0 2 0 0 2 2 2 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 PIK55746.1 - 0.11 11.2 0.1 2.5 6.8 0.1 2.0 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, BNR_2 PF13088.6 PIK55747.1 - 1.3e-23 83.7 0.0 2.7e-23 82.7 0.0 1.4 1 1 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 PIK55747.1 - 1.7e-05 24.2 0.0 7.9e-05 22.1 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.20 PIK55747.1 - 0.0044 16.8 10.1 1.8 8.9 0.3 5.2 6 0 0 6 6 6 3 BNR/Asp-box repeat JAB PF01398.21 PIK55749.1 - 1.4e-21 76.6 0.0 3.4e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 PIK55749.1 - 5.1e-16 59.1 0.9 7.7e-16 58.5 0.9 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF2748 PF10871.8 PIK55749.1 - 0.012 14.3 1.5 0.015 13.9 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) XendoU PF09412.10 PIK55749.1 - 0.047 12.9 0.3 0.065 12.4 0.3 1.2 1 0 0 1 1 1 0 Endoribonuclease XendoU Prok-JAB PF14464.6 PIK55749.1 - 0.055 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain Tyrosinase PF00264.20 PIK55750.1 - 6.4e-18 65.9 0.4 1.5e-12 48.3 0.0 2.4 1 1 1 2 2 2 2 Common central domain of tyrosinase Kunitz_BPTI PF00014.23 PIK55750.1 - 6.5e-15 55.1 6.6 6.5e-15 55.1 6.6 3.5 3 0 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain VWC PF00093.18 PIK55750.1 - 1.1e-06 28.9 8.7 1.1e-06 28.9 8.7 4.6 4 1 1 5 5 5 2 von Willebrand factor type C domain Macoilin PF09726.9 PIK55750.1 - 0.074 11.6 0.4 0.099 11.2 0.4 1.1 1 0 0 1 1 1 0 Macoilin family VWC PF00093.18 PIK55751.1 - 2e-10 40.8 14.8 2e-10 40.8 14.8 2.8 2 1 1 3 3 3 1 von Willebrand factor type C domain Amnionless PF14828.6 PIK55751.1 - 4.6 5.9 16.2 0.21 10.4 10.6 1.5 2 0 0 2 2 2 0 Amnionless VWC PF00093.18 PIK55752.1 - 6.2e-89 292.2 274.9 3.1e-11 43.4 15.6 13.1 13 0 0 13 13 13 13 von Willebrand factor type C domain TILa PF12714.7 PIK55752.1 - 4.9e-06 26.4 228.4 0.0077 16.2 7.5 14.9 10 4 4 15 15 15 11 TILa domain Ion_trans PF00520.31 PIK55753.1 - 2.3e-16 59.8 6.5 2.8e-16 59.5 6.5 1.0 1 0 0 1 1 1 1 Ion transport protein SHP PF03579.13 PIK55753.1 - 1.3 9.0 6.2 1.4 8.9 0.0 3.1 3 0 0 3 3 3 0 Small hydrophobic protein Ion_trans PF00520.31 PIK55754.1 - 5.2e-88 294.4 78.5 2.7e-31 108.7 13.1 4.1 4 0 0 4 4 4 4 Ion transport protein Ependymin PF00811.18 PIK55755.1 - 2.7e-10 40.6 0.0 3.3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Ependymin Ependymin PF00811.18 PIK55756.1 - 1.5e-09 38.2 0.9 3.1e-09 37.2 0.1 1.7 2 0 0 2 2 2 1 Ependymin Ependymin PF00811.18 PIK55757.1 - 1.4e-09 38.2 1.6 2.1e-09 37.7 0.1 1.8 2 0 0 2 2 2 1 Ependymin Ependymin PF00811.18 PIK55759.1 - 7.3e-12 45.6 0.3 1.3e-11 44.9 0.3 1.4 1 1 0 1 1 1 1 Ependymin ParcG PF10274.9 PIK55760.1 - 1e-80 270.2 0.0 1.2e-80 270.0 0.0 1.0 1 0 0 1 1 1 1 Parkin co-regulated protein Rhodanese PF00581.20 PIK55761.1 - 2.4e-13 50.5 0.0 3.9e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain WW PF00397.26 PIK55762.1 - 2.4e-09 37.1 0.3 4.4e-09 36.3 0.3 1.5 1 0 0 1 1 1 1 WW domain FAM181 PF15238.6 PIK55763.1 - 3.8e-07 30.2 1.8 4.5e-07 30.0 1.8 1.1 1 0 0 1 1 1 1 FAM181 WW PF00397.26 PIK55763.1 - 0.0096 16.0 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 WW domain CENP-I PF07778.11 PIK55764.1 - 4.2e-115 385.4 2.4 5.5e-115 385.0 2.4 1.1 1 0 0 1 1 1 1 Mis6 Sec34 PF04136.15 PIK55765.1 - 5.1e-46 156.2 11.3 5.1e-46 156.2 11.3 2.5 2 0 0 2 2 2 1 Sec34-like family KNOX2 PF03791.13 PIK55765.1 - 0.048 13.2 0.2 0.16 11.5 0.2 1.9 1 0 0 1 1 1 0 KNOX2 domain Syntaxin-6_N PF09177.11 PIK55765.1 - 0.054 14.1 4.3 0.089 13.4 1.2 3.0 3 0 0 3 3 3 0 Syntaxin 6, N-terminal DUF501 PF04417.12 PIK55765.1 - 0.075 12.8 0.6 0.36 10.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Nrf1_DNA-bind PF10491.9 PIK55765.1 - 0.085 12.5 0.2 0.19 11.4 0.2 1.5 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Fzo_mitofusin PF04799.13 PIK55765.1 - 1.4 8.4 10.0 6.4 6.3 2.6 2.9 2 0 0 2 2 2 0 fzo-like conserved region RNase_H2-Ydr279 PF09468.10 PIK55766.1 - 6e-18 65.5 1.4 1.5e-17 64.3 1.4 1.7 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 PIK55766.1 - 1.5e-13 50.7 0.2 4e-13 49.4 0.1 1.8 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain Ank_4 PF13637.6 PIK55767.1 - 1.4e-10 41.5 0.0 4.5e-06 27.1 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK55767.1 - 6.1e-10 39.1 0.0 0.0002 21.7 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 PIK55767.1 - 8.2e-10 39.1 0.0 3.7e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK55767.1 - 5e-07 29.9 0.2 3.8e-05 23.9 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK55767.1 - 8.9e-06 25.7 0.0 1 10.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Cu-oxidase_3 PF07732.15 PIK55769.1 - 1.7e-39 134.5 0.9 2.8e-38 130.6 0.2 3.1 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 PIK55769.1 - 4.8e-37 126.7 4.8 2.5e-32 111.5 0.1 3.5 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 PIK55769.1 - 5.4e-28 98.1 0.6 4e-27 95.3 0.0 2.5 3 0 0 3 3 3 1 Multicopper oxidase VWD PF00094.25 PIK55770.1 - 4.7e-21 75.7 0.1 7.8e-21 75.0 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Kazal_1 PF00050.21 PIK55770.1 - 7.9e-19 67.4 13.0 7.1e-11 41.9 3.2 4.6 2 1 2 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 PIK55770.1 - 1.9e-13 50.3 15.2 2.1e-08 34.2 3.1 4.3 2 1 1 3 3 3 2 Kazal-type serine protease inhibitor domain EGF PF00008.27 PIK55770.1 - 7.7e-13 48.5 29.0 2.2e-08 34.2 9.9 4.2 5 0 0 5 5 5 2 EGF-like domain hEGF PF12661.7 PIK55770.1 - 1.6e-09 38.1 19.9 3.6e-06 27.4 5.1 4.7 4 0 0 4 4 4 2 Human growth factor-like EGF C8 PF08742.11 PIK55770.1 - 1.3e-08 35.1 0.2 1.3e-08 35.1 0.2 4.7 5 3 1 6 6 6 1 C8 domain cEGF PF12662.7 PIK55770.1 - 0.00084 19.2 24.6 0.0043 16.9 3.2 4.2 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK55770.1 - 0.0096 16.1 5.7 0.0096 16.1 5.7 4.4 3 1 1 4 4 4 2 EGF domain FXa_inhibition PF14670.6 PIK55770.1 - 8.3 6.8 39.3 0.79 10.1 12.4 3.9 3 1 0 3 3 3 0 Coagulation Factor Xa inhibitory site VWD PF00094.25 PIK55771.1 - 1.5e-119 395.7 8.5 1.3e-30 106.8 0.1 6.0 5 1 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.11 PIK55771.1 - 2.7e-43 146.3 30.8 2.6e-14 53.4 2.9 9.5 10 1 2 12 12 12 5 C8 domain TILa PF12714.7 PIK55771.1 - 1.1e-29 102.1 79.9 4.6e-09 36.1 11.5 11.0 8 2 2 10 10 10 5 TILa domain TIL PF01826.17 PIK55771.1 - 1.9e-24 85.7 85.0 1.5e-10 41.1 17.8 16.5 11 4 3 14 14 14 5 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK55771.1 - 0.00024 21.2 54.9 0.0013 18.8 13.7 13.2 14 3 2 16 16 16 4 EGF domain Fibrinogen_C PF00147.18 PIK55772.1 - 3.4e-57 193.8 4.4 5.2e-57 193.2 4.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain C8 PF08742.11 PIK55772.1 - 2.2e-11 44.0 1.4 2.2e-11 44.0 1.4 2.8 2 1 1 3 3 3 1 C8 domain TIL PF01826.17 PIK55772.1 - 2.5e-08 34.1 16.3 2.5e-08 34.1 16.3 4.0 3 2 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK55772.1 - 0.0017 18.5 9.2 0.0017 18.5 9.2 3.7 3 1 0 3 3 3 1 EGF domain WD40 PF00400.32 PIK55773.1 - 0.16 12.9 13.6 0.71 10.8 0.2 4.3 6 0 0 6 6 6 0 WD domain, G-beta repeat Pkinase PF00069.25 PIK55774.1 - 7.5e-49 166.5 0.0 9.1e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55774.1 - 2.2e-32 112.4 0.0 2.8e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK55774.1 - 2.5e-06 27.0 0.0 5e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK55774.1 - 0.0012 18.2 0.1 0.0019 17.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK55774.1 - 0.0034 17.0 0.1 0.0064 16.1 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 PIK55774.1 - 0.017 14.7 0.2 0.03 13.9 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TSC22 PF01166.18 PIK55776.1 - 3.2e-18 65.8 0.9 7.5e-18 64.6 0.9 1.6 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 PIK55776.1 - 0.00088 19.9 1.8 0.0014 19.2 0.9 1.8 2 0 0 2 2 2 1 Initiation control protein YabA Lebercilin PF15619.6 PIK55776.1 - 0.012 15.3 1.2 0.02 14.6 1.2 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 PIK55776.1 - 0.014 15.8 2.4 0.032 14.7 2.4 1.6 1 0 0 1 1 1 0 Cell division protein ZapB DUF5101 PF17031.5 PIK55776.1 - 0.018 15.1 0.4 0.032 14.3 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) NRBF2 PF08961.10 PIK55776.1 - 0.018 14.6 0.2 0.044 13.4 0.2 1.7 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 PIK55776.1 - 0.02 14.6 1.9 0.04 13.7 1.9 1.4 1 0 0 1 1 1 0 Septum formation initiator HeLo PF14479.6 PIK55776.1 - 0.067 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation bZIP_1 PF00170.21 PIK55776.1 - 0.16 12.1 2.7 0.31 11.2 2.7 1.4 1 0 0 1 1 1 0 bZIP transcription factor HALZ PF02183.18 PIK55776.1 - 0.17 12.2 1.9 0.37 11.1 1.9 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 PIK55776.1 - 0.24 11.3 1.4 0.55 10.1 1.4 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 PIK55776.1 - 0.84 9.8 6.0 1.7 8.8 6.0 1.4 1 0 0 1 1 1 0 Basic region leucine zipper PCI PF01399.27 PIK55777.1 - 6.7e-17 61.9 1.4 1.4e-16 60.9 0.7 1.8 2 0 0 2 2 2 1 PCI domain SPRY PF00622.28 PIK55778.1 - 0.00054 20.1 0.0 0.00066 19.8 0.0 1.2 1 0 0 1 1 1 1 SPRY domain EDR1 PF14381.6 PIK55779.1 - 2.3e-41 141.7 0.1 8.8e-40 136.6 0.0 2.7 3 0 0 3 3 3 1 Ethylene-responsive protein kinase Le-CTR1 Arm PF00514.23 PIK55779.1 - 9.9e-39 130.2 26.4 3.8e-06 26.8 0.1 12.2 12 0 0 12 12 12 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK55779.1 - 6.1e-23 81.0 13.7 0.001 19.4 0.0 7.3 3 3 3 7 7 7 6 HEAT repeats HEAT PF02985.22 PIK55779.1 - 2.9e-17 61.3 15.9 0.011 15.9 0.1 10.0 10 0 0 10 10 10 5 HEAT repeat HEAT_EZ PF13513.6 PIK55779.1 - 3.5e-15 56.1 8.7 0.028 14.9 0.0 8.7 7 1 1 8 8 8 2 HEAT-like repeat V-ATPase_H_N PF03224.14 PIK55779.1 - 1e-08 34.9 1.7 0.0026 17.1 0.1 3.7 1 1 2 3 3 3 2 V-ATPase subunit H V-ATPase_H_C PF11698.8 PIK55779.1 - 1.5e-07 31.5 4.3 0.21 11.7 0.2 5.4 4 1 1 5 5 5 1 V-ATPase subunit H Arm_2 PF04826.13 PIK55779.1 - 1.6e-06 27.8 13.3 0.1 12.1 0.0 6.1 3 2 3 7 7 7 3 Armadillo-like KAP PF05804.12 PIK55779.1 - 9.3e-06 24.1 2.3 0.057 11.6 0.4 3.1 2 1 1 3 3 3 2 Kinesin-associated protein (KAP) Cnd1 PF12717.7 PIK55779.1 - 3e-05 24.1 7.4 1.6 8.8 0.1 4.8 2 2 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 CTNNBL PF08216.11 PIK55779.1 - 0.12 12.6 2.5 18 5.5 0.0 4.0 3 2 1 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear DUF5578 PF17741.1 PIK55779.1 - 0.13 11.7 9.1 0.62 9.4 1.3 3.9 3 1 2 5 5 5 0 Family of unknown function (DUF5578) Atx10homo_assoc PF09759.9 PIK55779.1 - 0.13 12.3 1.6 2.5 8.2 0.2 3.7 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 PIK55779.1 - 0.33 10.9 11.3 8 6.4 0.1 4.7 2 1 1 4 4 4 0 Domain of unknown function (DUF3361) Sdh5 PF03937.16 PIK55780.1 - 1.2e-23 82.8 0.0 2.1e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase AMP-binding PF00501.28 PIK55781.1 - 1.3e-98 330.4 0.0 1.7e-98 330.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK55781.1 - 0.0073 17.3 0.1 0.02 15.8 0.1 1.8 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_transf_64 PF09258.10 PIK55783.1 - 6.1e-94 313.9 0.0 7.2e-94 313.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 PIK55784.1 - 4.7e-25 88.4 0.4 1.2e-22 80.6 0.0 2.6 1 1 1 2 2 2 1 Exostosin family DUF1635 PF07795.11 PIK55784.1 - 0.00082 19.3 1.0 0.0012 18.8 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) ZapD PF07072.11 PIK55784.1 - 0.0021 17.8 4.1 0.004 16.9 4.1 1.4 1 0 0 1 1 1 1 Cell division protein RmuC PF02646.16 PIK55784.1 - 0.0056 15.9 1.6 0.0089 15.2 1.6 1.2 1 0 0 1 1 1 1 RmuC family RasGAP_C PF03836.15 PIK55784.1 - 0.0056 16.8 5.0 0.01 16.0 5.0 1.3 1 0 0 1 1 1 1 RasGAP C-terminus DUF812 PF05667.11 PIK55784.1 - 0.009 14.9 3.4 0.012 14.5 3.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) THOC7 PF05615.13 PIK55784.1 - 0.012 15.9 3.0 0.022 15.0 3.0 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 Leu_zip PF15294.6 PIK55784.1 - 0.013 15.0 2.7 0.021 14.3 2.7 1.2 1 0 0 1 1 1 0 Leucine zipper Myosin_tail_1 PF01576.19 PIK55784.1 - 0.016 13.0 6.5 0.022 12.6 6.5 1.1 1 0 0 1 1 1 0 Myosin tail APG6_N PF17675.1 PIK55784.1 - 0.031 14.8 6.6 0.071 13.6 6.6 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Laminin_II PF06009.12 PIK55784.1 - 0.032 14.2 3.3 0.057 13.4 3.3 1.3 1 0 0 1 1 1 0 Laminin Domain II Golgin_A5 PF09787.9 PIK55784.1 - 0.035 13.6 10.0 0.016 14.7 7.7 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 Spc7 PF08317.11 PIK55784.1 - 0.041 12.8 4.7 0.063 12.2 4.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ATP-synt_B PF00430.18 PIK55784.1 - 0.042 14.0 4.0 0.081 13.0 4.0 1.4 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) ParcG PF10274.9 PIK55784.1 - 0.043 13.9 0.1 0.082 13.0 0.1 1.4 1 0 0 1 1 1 0 Parkin co-regulated protein Cluap1 PF10234.9 PIK55784.1 - 0.05 13.0 4.5 0.081 12.3 4.5 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF148 PF02520.17 PIK55784.1 - 0.086 12.9 5.7 0.16 12.1 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 Exonuc_VII_L PF02601.15 PIK55784.1 - 0.099 12.2 2.0 0.14 11.7 2.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OEP PF02321.18 PIK55784.1 - 0.12 12.2 7.8 0.21 11.4 7.8 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein Uds1 PF15456.6 PIK55784.1 - 0.12 12.5 8.2 0.14 12.3 4.1 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Syntaxin-6_N PF09177.11 PIK55784.1 - 0.16 12.5 3.2 0.37 11.4 3.2 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal IFT57 PF10498.9 PIK55784.1 - 0.17 10.9 6.4 0.26 10.2 6.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 UPF0242 PF06785.11 PIK55784.1 - 0.18 11.9 6.1 0.025 14.7 2.2 1.6 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus YPEB PF14620.6 PIK55784.1 - 0.23 10.7 4.0 0.48 9.7 1.6 2.0 2 0 0 2 2 2 0 YpeB sporulation DUF3450 PF11932.8 PIK55784.1 - 0.26 10.6 7.9 0.4 10.0 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) BRE1 PF08647.11 PIK55784.1 - 0.26 11.4 6.9 0.46 10.6 6.9 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase HIP1_clath_bdg PF16515.5 PIK55784.1 - 0.3 11.7 9.1 0.64 10.7 9.1 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Jnk-SapK_ap_N PF09744.9 PIK55784.1 - 0.35 11.1 13.3 0.09 13.0 9.5 1.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.12 PIK55784.1 - 0.36 10.9 1.6 0.68 10.0 1.6 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 PIK55784.1 - 0.39 10.7 1.9 0.83 9.7 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ZYG-11_interact PF05884.12 PIK55784.1 - 0.4 10.1 1.6 0.43 9.9 0.8 1.4 1 1 0 1 1 1 0 Interactor of ZYG-11 Lectin_N PF03954.14 PIK55784.1 - 0.58 9.9 4.6 3.4 7.4 2.1 2.8 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain COG2 PF06148.11 PIK55784.1 - 1 9.5 5.8 3.5 7.7 5.8 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.12 PIK55784.1 - 1.2 9.7 3.7 3.7 8.1 3.7 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FapA PF03961.13 PIK55784.1 - 1.3 7.5 3.1 1.9 7.0 3.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 PIK55784.1 - 1.7 8.9 9.1 3.1 8.1 9.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Gtr1_RagA PF04670.12 PIK55785.1 - 1.2e-73 247.3 1.4 1.5e-73 247.0 1.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK55785.1 - 4.5e-05 23.0 0.0 9.5e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 PIK55785.1 - 0.00016 21.9 0.0 0.00024 21.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK55785.1 - 0.00056 19.4 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 PIK55785.1 - 0.0025 17.4 0.0 0.0053 16.4 0.1 1.6 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 PIK55785.1 - 0.0037 17.3 0.0 0.0088 16.1 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_14 PF13173.6 PIK55785.1 - 0.085 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK55785.1 - 0.095 13.1 0.0 0.28 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain UCR_hinge PF02320.16 PIK55786.1 - 2.8e-19 69.1 6.0 4.3e-19 68.5 6.0 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.13 PIK55786.1 - 0.0068 16.3 0.6 0.0077 16.1 0.6 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region Ku_C PF03730.14 PIK55786.1 - 0.15 12.8 2.8 0.19 12.5 2.8 1.2 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm ATP-synt_DE_N PF02823.16 PIK55787.1 - 8.8e-15 54.4 0.0 1.2e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain AtuA PF07287.11 PIK55787.1 - 0.034 12.9 0.0 0.041 12.6 0.0 1.1 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA RVT_1 PF00078.27 PIK55788.1 - 1.9e-30 106.0 0.1 4e-30 105.0 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GFO_IDH_MocA PF01408.22 PIK55789.1 - 1.3e-18 68.0 0.0 2.3e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK55789.1 - 1.3e-05 25.2 0.0 2.3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 PIK55789.1 - 0.066 13.8 1.1 0.14 12.7 0.2 2.1 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 PIK55789.1 - 0.084 13.1 0.0 0.38 11.0 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain TauD PF02668.16 PIK55790.1 - 1.2e-13 51.5 0.0 1.2e-06 28.6 0.0 2.3 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 PIK55790.1 - 2.2e-12 47.4 0.0 4.9e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 PIK55790.1 - 0.06 12.5 0.0 0.27 10.3 0.0 1.9 2 0 0 2 2 2 0 CsiD TauD PF02668.16 PIK55791.1 - 3.4e-07 30.3 0.1 4.2e-07 30.0 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF2771 PF10969.8 PIK55792.1 - 0.042 13.9 0.0 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2771) DUF4658 PF15555.6 PIK55792.1 - 0.045 13.9 2.6 1.2 9.3 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) Pex24p PF06398.11 PIK55792.1 - 0.18 10.8 0.0 0.3 10.0 0.0 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin PALP PF00291.25 PIK55793.1 - 6.3e-40 137.4 1.2 4e-39 134.8 1.1 2.0 1 1 1 2 2 2 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 PIK55793.1 - 3.2e-06 26.8 0.1 7.4e-06 25.6 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 PIK55793.1 - 0.0055 17.3 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 PIK55793.1 - 0.018 15.0 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 ACT domain Jiv90 PF14901.6 PIK55794.1 - 3e-21 75.4 0.9 9.3e-21 73.8 0.9 1.9 1 0 0 1 1 1 1 Cleavage inducing molecular chaperone DnaJ PF00226.31 PIK55794.1 - 6.3e-15 55.0 0.2 1.5e-14 53.9 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Cryptochrome_C PF12546.8 PIK55794.1 - 7.1 7.3 8.1 0.76 10.4 0.4 3.2 3 0 0 3 3 3 0 Blue/Ultraviolet sensing protein C terminal DEAD PF00270.29 PIK55795.1 - 8.5e-49 165.7 0.0 2e-48 164.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK55795.1 - 6.2e-33 113.5 0.0 1.1e-30 106.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-CCHC PF00098.23 PIK55795.1 - 3.5e-05 23.7 4.1 3.5e-05 23.7 4.1 1.9 2 0 0 2 2 2 1 Zinc knuckle ResIII PF04851.15 PIK55795.1 - 0.0011 19.0 0.0 0.0039 17.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HEM4 PF02602.15 PIK55795.1 - 0.0038 16.6 0.1 0.0064 15.9 0.1 1.3 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD ERCC3_RAD25_C PF16203.5 PIK55795.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-CCHC_3 PF13917.6 PIK55795.1 - 0.023 14.6 0.0 0.084 12.9 0.1 1.9 2 0 0 2 2 2 0 Zinc knuckle CMS1 PF14617.6 PIK55795.1 - 0.042 13.2 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit EGF PF00008.27 PIK55796.1 - 1.2e-05 25.5 3.9 1.2e-05 25.5 3.9 2.0 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 PIK55796.1 - 0.05 14.0 7.8 0.26 11.7 7.8 2.1 1 1 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 PIK55796.1 - 0.14 12.4 5.8 0.25 11.5 5.8 1.5 1 1 0 1 1 1 0 Laminin EGF domain DUF3844 PF12955.7 PIK55796.1 - 0.2 11.8 5.2 0.057 13.5 2.3 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3844) EGF PF00008.27 PIK55797.1 - 8e-08 32.4 4.5 1.3e-07 31.8 4.5 1.3 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 PIK55797.1 - 0.08 13.3 5.1 0.13 12.6 5.1 1.3 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 PIK55797.1 - 0.18 12.5 4.9 0.1 13.2 2.4 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 PIK55798.1 - 1.4e-25 89.2 58.0 0.00014 22.1 4.7 6.3 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 PIK55798.1 - 1.7e-10 41.1 44.0 0.15 12.8 2.2 7.6 6 0 0 6 6 6 5 Human growth factor-like EGF Laminin_EGF PF00053.24 PIK55798.1 - 2.4e-09 37.2 54.6 0.19 11.9 3.7 6.2 6 0 0 6 6 6 6 Laminin EGF domain DUF1157 PF06636.11 PIK55798.1 - 0.00048 19.1 0.0 14 4.4 0.0 4.7 4 2 1 5 5 5 1 Protein of unknown function (DUF1157) IL4Ra_N PF09238.10 PIK55798.1 - 0.0019 18.5 24.3 3.1 8.2 0.2 5.9 6 0 0 6 6 6 4 Interleukin-4 receptor alpha chain, N-terminal EGF_2 PF07974.13 PIK55798.1 - 0.017 15.5 67.4 1.4 9.3 6.3 6.2 6 0 0 6 6 6 0 EGF-like domain Fer4 PF00037.27 PIK55798.1 - 0.82 9.6 6.8 1.8e+02 2.2 0.0 5.3 5 0 0 5 5 5 0 4Fe-4S binding domain RVT_1 PF00078.27 PIK55799.1 - 4.2e-26 91.8 0.0 5.3e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3479 PF11965.8 PIK55799.1 - 0.09 12.9 0.0 0.14 12.2 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3479) Activin_recp PF01064.23 PIK55800.1 - 0.0045 18.0 0.8 2 9.6 0.5 2.6 2 0 0 2 2 2 2 Activin types I and II receptor domain Syntaxin-5_N PF11416.8 PIK55800.1 - 0.11 11.8 4.4 7.8 5.9 0.4 3.4 2 0 0 2 2 2 0 Syntaxin-5 N-terminal, Sly1p-binding domain Fer4_20 PF14691.6 PIK55801.1 - 9.4e-33 112.4 0.2 1.7e-32 111.6 0.2 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster DHO_dh PF01180.21 PIK55801.1 - 5.2e-30 104.7 0.0 1e-29 103.7 0.0 1.5 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Pyr_redox_2 PF07992.14 PIK55801.1 - 9.7e-14 51.3 0.0 2e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Dus PF01207.17 PIK55801.1 - 1.8e-07 30.6 0.2 8.1e-07 28.4 0.4 1.8 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Pyr_redox_3 PF13738.6 PIK55801.1 - 1.7e-06 27.5 0.0 0.0015 17.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK55801.1 - 1.8e-06 28.0 0.0 6.7e-06 26.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 PIK55801.1 - 0.0003 21.3 0.1 0.12 12.9 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 PIK55801.1 - 0.055 13.5 0.0 8.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 PIK55801.1 - 0.089 12.4 0.1 0.96 9.0 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Fer4_10 PF13237.6 PIK55801.1 - 2.3 8.4 12.1 0.48 10.6 6.7 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain fn3 PF00041.21 PIK55802.1 - 8e-15 55.0 6.0 8.4e-07 29.3 0.7 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Y_phosphatase PF00102.27 PIK55802.1 - 2.7e-06 27.1 0.0 9.9e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Pur_ac_phosph_N PF16656.5 PIK55802.1 - 1.1e-05 26.0 6.0 0.0028 18.2 1.3 2.9 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain REJ PF02010.15 PIK55802.1 - 0.0063 15.4 0.0 0.036 12.8 0.0 1.9 1 1 0 1 1 1 1 REJ domain TMEM154 PF15102.6 PIK55802.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF4448 PF14610.6 PIK55802.1 - 0.041 13.7 0.0 0.13 12.0 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4448) DUF5305 PF17231.2 PIK55802.1 - 0.045 13.2 0.1 0.081 12.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Glycophorin_A PF01102.18 PIK55802.1 - 0.059 13.6 1.5 0.13 12.5 0.8 2.0 1 1 0 1 1 1 0 Glycophorin A Herpes_gE PF02480.16 PIK55802.1 - 0.075 11.8 0.0 1.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DUF2207 PF09972.9 PIK55802.1 - 0.19 10.4 1.5 0.58 8.9 0.7 2.1 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) GPI-anchored PF10342.9 PIK55802.1 - 0.37 11.6 10.4 0.12 13.2 1.7 3.1 2 1 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Y_phosphatase PF00102.27 PIK55803.1 - 7.4e-69 231.9 0.1 3e-37 128.4 0.4 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK55803.1 - 0.00046 20.0 0.5 0.0016 18.3 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK55803.1 - 0.038 14.1 0.2 0.21 11.7 0.0 2.2 2 1 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 PIK55804.1 - 8.6e-17 61.5 0.0 9.3e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK55804.1 - 0.011 15.5 0.0 0.029 14.2 0.0 1.5 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Glyco_transf_29 PF00777.18 PIK55805.1 - 3e-27 95.7 0.1 3.5e-27 95.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SET PF00856.28 PIK55808.1 - 0.013 15.9 0.0 0.013 15.9 0.0 3.4 2 1 0 2 2 2 0 SET domain HTHP PF11534.8 PIK55808.1 - 0.031 14.7 1.5 2.7 8.5 0.1 3.0 2 1 0 2 2 2 0 Hexameric tyrosine-coordinated heme protein (HTHP) Ribosomal_L25p PF01386.19 PIK55808.1 - 0.16 12.5 1.2 4.2 8.0 0.0 3.2 1 1 2 4 4 4 0 Ribosomal L25p family RVT_1 PF00078.27 PIK55809.1 - 1.2e-05 25.0 0.1 4.3e-05 23.1 0.1 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HA PF03457.14 PIK55809.1 - 0.065 13.6 0.0 0.21 12.0 0.0 1.9 1 0 0 1 1 1 0 Helicase associated domain zf-CCHC PF00098.23 PIK55810.1 - 1.5e-07 31.1 15.8 0.00046 20.1 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK55810.1 - 0.011 15.4 11.1 3.5 7.4 0.4 3.5 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK55810.1 - 0.013 15.3 13.2 0.07 13.0 3.8 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55810.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK55810.1 - 0.016 14.9 0.8 0.016 14.9 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK55810.1 - 0.059 13.3 16.4 0.26 11.3 1.7 3.6 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC PF00098.23 PIK55811.1 - 4e-07 29.8 15.8 0.00058 19.8 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK55811.1 - 0.00039 20.2 7.7 0.089 12.7 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55811.1 - 0.019 14.8 0.2 0.019 14.8 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK55811.1 - 0.02 14.6 0.8 0.02 14.6 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK55811.1 - 0.025 14.3 11.3 4.4 7.1 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK55811.1 - 0.058 13.4 18.0 0.21 11.6 1.2 4.1 3 1 2 5 5 5 0 Zinc knuckle Exo_endo_phos PF03372.23 PIK55812.1 - 3.3e-06 26.8 0.0 1.4e-05 24.7 0.0 2.1 1 1 1 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RBD-FIP PF09457.10 PIK55813.1 - 0.006 16.5 1.9 0.006 16.5 1.9 4.8 4 1 0 4 4 4 1 FIP domain ATG16 PF08614.11 PIK55813.1 - 0.0067 16.7 17.8 0.0067 16.7 17.8 6.6 2 1 4 7 7 7 1 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 PIK55813.1 - 0.013 15.6 7.6 0.013 15.6 7.6 6.6 3 3 4 7 7 7 0 Protein of unknown function (DUF1664) DUF1796 PF08795.10 PIK55813.1 - 1.5 8.7 7.1 1.8 8.5 3.3 2.8 1 1 1 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) Pkinase PF00069.25 PIK55814.1 - 5.6e-54 183.3 0.1 4.9e-35 121.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK55814.1 - 6.3e-25 87.9 0.1 2.9e-11 43.2 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase RnlA_toxin PF15935.5 PIK55814.1 - 0.017 14.9 0.6 0.04 13.7 0.0 1.9 3 0 0 3 3 3 0 RNase LS, bacterial toxin TMEM65 PF10507.9 PIK55817.1 - 1.5e-44 150.4 1.1 2.1e-44 149.9 1.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 65 Rtf2 PF04641.12 PIK55818.1 - 1e-83 280.7 7.0 1.8e-83 279.9 7.0 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 PIK55818.1 - 0.0094 15.8 0.0 0.024 14.5 0.0 1.7 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rpr2 PF04032.16 PIK55818.1 - 0.067 13.5 1.4 0.18 12.1 0.1 2.3 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ank_4 PF13637.6 PIK55819.1 - 4.4e-54 180.2 1.2 2.8e-10 40.5 0.0 6.7 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK55819.1 - 3.7e-51 171.7 0.7 1.1e-15 58.0 0.4 4.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK55819.1 - 7.6e-39 131.3 3.2 5.8e-08 32.9 0.0 6.1 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK55819.1 - 7.1e-38 127.4 10.4 1.4e-05 25.4 0.1 7.7 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 PIK55819.1 - 3.2e-35 116.1 3.4 4.6e-06 26.6 0.0 8.0 9 0 0 9 9 9 6 Ankyrin repeat ANAPC4_WD40 PF12894.7 PIK55820.1 - 7.2e-11 42.2 1.3 0.00096 19.4 0.2 5.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 PIK55820.1 - 7.2e-10 38.9 30.3 0.46 10.4 0.3 9.5 6 3 3 10 10 10 5 Region in Clathrin and VPS WD40 PF00400.32 PIK55820.1 - 8.3e-08 32.8 1.9 2 9.4 0.0 6.6 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC3 PF12895.7 PIK55820.1 - 0.00051 20.2 17.6 2 8.7 0.0 8.4 7 2 0 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 BBS2_Mid PF14783.6 PIK55820.1 - 0.023 14.7 1.1 0.14 12.2 0.2 2.7 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Coatomer_WDAD PF04053.14 PIK55820.1 - 0.026 13.6 11.8 0.13 11.2 0.2 5.2 3 2 1 5 5 5 0 Coatomer WD associated region TPR_7 PF13176.6 PIK55820.1 - 0.027 14.5 23.7 5.1 7.4 0.1 10.1 11 3 0 11 11 11 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK55820.1 - 0.068 13.8 11.8 1.2 9.9 0.2 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat eIF2A PF08662.11 PIK55820.1 - 0.094 12.6 0.2 2.8 7.8 0.1 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A TPR_11 PF13414.6 PIK55820.1 - 0.42 10.4 10.2 2.5 7.9 0.2 6.3 7 0 0 7 7 7 0 TPR repeat DUF1394 PF07159.12 PIK55821.1 - 7e-123 409.7 1.8 8.9e-123 409.4 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Myc_N PF01056.18 PIK55822.1 - 9.2e-17 61.9 16.8 3.5e-09 37.0 1.7 3.2 1 1 2 3 3 3 3 Myc amino-terminal region MAGE_N PF12440.8 PIK55822.1 - 0.046 14.4 0.5 0.046 14.4 0.5 2.1 3 0 0 3 3 3 0 Melanoma associated antigen family N terminal IPPT PF01715.17 PIK55823.1 - 1.7e-45 155.6 0.2 1.3e-24 87.3 0.0 3.3 2 1 0 2 2 2 2 IPP transferase IPT PF01745.16 PIK55823.1 - 1e-05 25.0 0.0 1.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Isopentenyl transferase AAA_16 PF13191.6 PIK55823.1 - 0.018 15.4 0.0 0.048 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 PIK55823.1 - 0.082 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK55823.1 - 0.087 13.2 0.0 0.27 11.6 0.0 1.9 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 PIK55823.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 PIK55823.1 - 0.11 11.7 0.1 0.26 10.5 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 PIK55823.1 - 0.13 12.6 0.0 0.66 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 PIK55823.1 - 0.15 12.6 0.1 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 ABC transporter MFS_1 PF07690.16 PIK55824.1 - 5.7e-28 97.8 26.5 1.5e-16 60.3 10.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily 7tm_1 PF00001.21 PIK55825.1 - 7.4e-40 136.9 13.9 9.3e-40 136.6 13.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK55825.1 - 0.00019 20.8 5.7 0.00019 20.8 5.7 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF4790 PF16037.5 PIK55825.1 - 0.12 12.8 0.1 0.49 10.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) AgrB PF04647.15 PIK55825.1 - 0.15 11.4 9.5 0.024 13.9 4.7 2.1 1 1 1 2 2 2 0 Accessory gene regulator B TssN PF17555.2 PIK55825.1 - 0.2 11.0 10.0 0.036 13.5 1.1 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssN TPR_10 PF13374.6 PIK55826.1 - 0.014 15.3 1.7 2.3 8.2 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF5338 PF17273.2 PIK55826.1 - 0.078 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5338) gag-asp_proteas PF13975.6 PIK55827.1 - 0.0059 17.1 0.0 0.013 16.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK55827.1 - 0.022 15.4 0.0 0.093 13.4 0.0 2.0 1 1 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.27 PIK55828.1 - 6e-27 94.6 0.0 9.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.29 PIK55830.1 - 5.1e-08 32.7 6.4 5.1e-08 32.7 6.4 1.5 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 PIK55830.1 - 0.0021 18.3 0.9 0.0021 18.3 0.9 1.7 2 0 0 2 2 2 1 PHD-like zinc-binding domain C1_2 PF03107.16 PIK55830.1 - 0.0038 17.5 0.9 0.0038 17.5 0.9 2.2 3 0 0 3 3 3 1 C1 domain PhnA_Zn_Ribbon PF08274.12 PIK55830.1 - 0.032 14.2 1.4 8.7 6.4 0.8 2.8 2 1 0 2 2 2 0 PhnA Zinc-Ribbon PHD_2 PF13831.6 PIK55830.1 - 0.13 11.8 6.3 1.3 8.6 6.3 2.3 1 1 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.6 PIK55830.1 - 0.16 12.3 6.9 0.51 10.7 7.0 1.8 1 1 1 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 PIK55830.1 - 0.84 9.4 5.7 1.9 8.3 5.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger C1_1 PF00130.22 PIK55830.1 - 2.3 8.2 9.8 0.11 12.4 2.7 2.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ribosomal_L24 PF17136.4 PIK55831.1 - 2e-10 40.9 0.1 4.3e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 PIK55831.1 - 1e-07 31.7 0.3 1e-07 31.7 0.3 3.0 4 0 0 4 4 4 1 KOW motif GCV_T PF01571.21 PIK55832.1 - 4e-68 229.6 0.0 6e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 PIK55832.1 - 1.7e-61 208.8 0.3 2.9e-61 208.0 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.11 PIK55832.1 - 4.5e-17 61.7 0.0 1e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 PIK55832.1 - 4.8e-12 46.0 0.0 1.3e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_3 PF13738.6 PIK55832.1 - 7.4e-08 32.0 0.0 0.0038 16.5 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SoxG PF04268.12 PIK55832.1 - 4.8e-05 23.5 0.0 9.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family NAD_binding_8 PF13450.6 PIK55832.1 - 7.1e-05 23.0 0.4 0.00086 19.5 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 PIK55832.1 - 0.00044 19.5 0.0 0.00091 18.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK55832.1 - 0.00055 19.3 0.0 0.0016 17.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK55832.1 - 0.0054 16.0 0.1 0.0096 15.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.16 PIK55832.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 PIK55832.1 - 0.015 14.6 0.1 0.05 12.8 0.0 1.9 2 1 1 3 3 3 0 FAD binding domain NAD_binding_9 PF13454.6 PIK55832.1 - 0.03 14.3 0.0 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 PIK55832.1 - 0.058 13.3 0.2 0.1 12.4 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 PIK55832.1 - 0.13 12.3 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 PIK55832.1 - 0.18 12.1 0.0 0.62 10.3 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 PIK55832.1 - 0.19 12.2 0.0 0.39 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 PIK55832.1 - 0.2 12.3 0.4 0.51 10.9 0.4 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase S-methyl_trans PF02574.16 PIK55833.1 - 5.1e-43 147.8 0.0 6.6e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Integrase_H2C2 PF17921.1 PIK55834.1 - 1.7e-13 50.5 0.0 4.1e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK55834.1 - 4e-05 23.5 1.0 4e-05 23.5 1.0 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.10 PIK55834.1 - 0.00022 21.4 0.0 0.00047 20.3 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC_4 PF14392.6 PIK55834.1 - 0.0065 16.2 0.7 0.014 15.1 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK55834.1 - 0.26 11.0 2.3 0.71 9.6 2.3 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVT_1 PF00078.27 PIK55835.1 - 2.8e-18 66.3 0.1 9.6e-18 64.5 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4371 PF14291.6 PIK55836.1 - 1.3e-31 110.1 1.0 1.2e-30 106.9 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK55836.1 - 0.026 14.4 0.3 0.12 12.3 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF 659) DUF4780 PF16012.5 PIK55836.1 - 0.044 13.2 0.1 0.1 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) RVT_1 PF00078.27 PIK55837.1 - 1.5e-13 50.8 0.2 1.1e-09 38.1 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MCRS_N PF13325.6 PIK55837.1 - 0.076 13.0 0.0 0.093 12.7 0.0 1.1 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein rve PF00665.26 PIK55838.1 - 9.7e-19 67.7 0.0 1.5e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK55838.1 - 3e-14 52.9 0.0 9.1e-14 51.3 0.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK55838.1 - 0.0003 20.5 0.0 0.00059 19.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK55838.1 - 0.00059 20.0 0.0 0.0015 18.7 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 PIK55839.1 - 0.0015 18.5 8.5 0.0051 16.8 3.5 2.4 2 0 0 2 2 2 2 Zinc knuckle Retrotrans_gag PF03732.17 PIK55839.1 - 0.11 12.8 0.1 1.2 9.5 0.0 2.5 3 0 0 3 3 3 0 Retrotransposon gag protein zf-CCHC_5 PF14787.6 PIK55839.1 - 1.9 8.3 10.5 2.8 7.7 2.2 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Exo_endo_phos_2 PF14529.6 PIK55840.1 - 7e-06 25.9 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase MFS_1 PF07690.16 PIK55841.1 - 2.9e-11 42.9 3.8 3.6e-11 42.6 3.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily VWC PF00093.18 PIK55842.1 - 1.7e-08 34.6 21.7 2e-06 28.0 7.9 4.7 4 0 0 4 4 4 2 von Willebrand factor type C domain Pacifastin_I PF05375.13 PIK55842.1 - 1.3e-07 31.2 19.3 0.00026 20.6 5.3 3.6 3 0 0 3 3 3 2 Pacifastin inhibitor (LCMII) TILa PF12714.7 PIK55842.1 - 8.3e-05 22.5 28.9 0.0023 17.8 2.5 3.9 3 0 0 3 3 3 2 TILa domain CFC PF09443.10 PIK55842.1 - 0.0028 17.4 12.4 0.31 10.9 2.8 2.9 2 0 0 2 2 2 2 Cripto_Frl-1_Cryptic (CFC) Rax2 PF12768.7 PIK55842.1 - 0.015 14.8 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity GCV_H PF01597.19 PIK55842.1 - 0.12 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein Homeodomain PF00046.29 PIK55844.1 - 1.6e-19 69.5 5.5 2.7e-19 68.8 5.5 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK55844.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain XRN_M PF17846.1 PIK55846.1 - 2.5e-151 504.6 0.0 2.5e-151 504.6 0.0 1.4 2 0 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 PIK55846.1 - 1.3e-100 335.9 0.0 2.1e-100 335.1 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus RhoGEF PF00621.20 PIK55847.1 - 5.3e-42 144.1 0.2 5.3e-42 144.1 0.2 3.5 4 0 0 4 4 4 1 RhoGEF domain PH PF00169.29 PIK55847.1 - 5.3e-06 26.9 0.1 1.8e-05 25.2 0.1 1.9 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 PIK55847.1 - 0.0025 18.0 1.0 0.012 15.8 0.5 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PCMT PF01135.19 PIK55848.1 - 8.3e-64 215.2 1.4 3.5e-63 213.2 1.4 1.7 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 PIK55848.1 - 1.6e-10 41.0 0.0 3.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK55848.1 - 1.1e-08 35.7 0.0 2.1e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK55848.1 - 2.9e-07 31.0 0.1 1.2e-06 29.1 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK55848.1 - 8.5e-06 25.3 0.0 1.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 PIK55848.1 - 1.8e-05 24.3 0.1 3.4e-05 23.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK55848.1 - 1.8e-05 24.7 0.0 3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 PIK55848.1 - 2.9e-05 24.1 0.1 5e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 PIK55848.1 - 0.00063 19.3 0.1 0.0016 18.0 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase small domain Fibrillarin PF01269.17 PIK55848.1 - 0.0015 17.7 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin Methyltransf_24 PF13578.6 PIK55848.1 - 0.0016 19.4 0.0 0.003 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK55848.1 - 0.0039 17.0 0.0 0.0093 15.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 PIK55848.1 - 0.024 13.8 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltr_RsmB-F PF01189.17 PIK55848.1 - 0.029 14.0 0.0 0.076 12.6 0.0 1.7 1 1 1 2 2 2 0 16S rRNA methyltransferase RsmB/F VPS13_mid_rpt PF16910.5 PIK55848.1 - 0.052 13.0 0.1 0.077 12.4 0.1 1.2 1 0 0 1 1 1 0 Repeating coiled region of VPS13 Methyltransf_12 PF08242.12 PIK55848.1 - 0.061 14.1 0.0 0.19 12.5 0.0 1.9 2 1 0 2 2 1 0 Methyltransferase domain FtsJ PF01728.19 PIK55848.1 - 0.067 13.3 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase sCache_3_3 PF17202.4 PIK55848.1 - 0.075 13.5 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 Single cache domain 3 AviRa PF11599.8 PIK55848.1 - 0.086 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_9 PF08003.11 PIK55848.1 - 0.15 11.0 0.0 0.36 9.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Nitroreductase PF00881.24 PIK55849.1 - 1.3e-12 48.1 0.0 1.7e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 PIK55849.1 - 0.01 15.4 0.0 0.33 10.5 0.0 2.1 2 0 0 2 2 2 0 Putative TM nitroreductase Ank_2 PF12796.7 PIK55850.1 - 5.4e-69 228.8 12.8 3.1e-10 40.5 0.0 8.9 1 1 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK55850.1 - 6.9e-56 186.0 15.4 7.2e-10 39.2 0.1 13.1 7 5 6 14 14 14 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK55850.1 - 4e-49 164.0 14.7 1.2e-08 35.0 0.4 11.1 6 4 5 11 11 11 11 Ankyrin repeats (many copies) Ank PF00023.30 PIK55850.1 - 1.1e-40 136.4 18.6 0.0005 20.4 0.1 15.3 14 1 0 14 14 14 10 Ankyrin repeat Ank_3 PF13606.6 PIK55850.1 - 3.3e-40 131.5 12.8 0.00013 22.1 0.0 15.8 17 0 0 17 17 17 9 Ankyrin repeat TT_ORF2 PF02957.15 PIK55850.1 - 3.7 8.5 7.6 0.43 11.5 0.4 2.6 2 0 0 2 2 2 0 TT viral ORF2 Nitroreductase PF00881.24 PIK55851.1 - 7.4e-21 74.9 0.0 9.5e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 PIK55851.1 - 2.1e-06 27.5 0.1 0.3 10.6 0.0 3.1 2 1 1 3 3 3 3 Putative TM nitroreductase DUF1801 PF08818.11 PIK55851.1 - 0.11 13.0 0.0 0.84 10.2 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DU1801) Shikimate_dh_N PF08501.11 PIK55852.1 - 0.17 12.2 0.1 0.55 10.5 0.0 1.9 2 0 0 2 2 2 0 Shikimate dehydrogenase substrate binding domain PP1_inhibitor PF05361.12 PIK55853.1 - 8e-08 32.4 0.1 9.7e-08 32.1 0.1 1.0 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor MANEC PF07502.14 PIK55855.1 - 3.7e-18 65.6 4.9 8.5e-18 64.4 4.9 1.6 1 0 0 1 1 1 1 MANEC domain Ldl_recept_a PF00057.18 PIK55855.1 - 3.4e-08 33.6 5.7 3.4e-08 33.6 5.7 2.8 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A Arginase PF00491.21 PIK55856.1 - 5.7e-67 226.2 0.1 6.8e-67 225.9 0.1 1.0 1 0 0 1 1 1 1 Arginase family RT_RNaseH_2 PF17919.1 PIK55858.1 - 1.6e-30 105.1 0.9 3.8e-30 103.9 0.4 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK55858.1 - 1.3e-18 67.4 0.0 4.3e-18 65.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK55858.1 - 3.7e-17 62.5 0.0 1.2e-16 60.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK55858.1 - 3.3e-15 55.9 1.2 3.3e-15 55.9 1.2 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK55858.1 - 0.0028 17.4 0.1 0.02 14.7 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Ferrochelatase PF00762.19 PIK55858.1 - 0.025 13.7 0.1 0.45 9.5 0.0 2.2 1 1 1 2 2 2 0 Ferrochelatase Pyridoxal_deC PF00282.19 PIK55859.1 - 3.5e-11 42.4 0.0 1.8e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Thioredoxin_6 PF13848.6 PIK55859.1 - 0.051 13.5 0.0 16 5.4 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain 40S_SA_C PF16122.5 PIK55860.1 - 9.5e-11 42.9 26.3 6.3e-09 37.1 26.3 2.1 1 1 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.20 PIK55861.1 - 6.1e-19 68.1 0.4 4.1e-14 52.3 0.0 2.0 1 1 1 2 2 2 2 Ribosomal protein S2 Urocanase_N PF17391.2 PIK55861.1 - 0.024 14.3 0.0 0.035 13.8 0.0 1.1 1 0 0 1 1 1 0 Urocanase N-terminal domain DNA_gyraseA_C PF03989.13 PIK55861.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller XendoU PF09412.10 PIK55862.1 - 3.1e-65 220.0 2.5 4.6e-65 219.5 2.5 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK55862.1 - 4.9e-27 94.0 96.2 2e-09 37.7 16.9 4.9 4 1 1 5 5 5 4 Somatomedin B domain EndoU_bacteria PF14436.6 PIK55862.1 - 0.00043 20.6 0.0 0.00089 19.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial EndoU nuclease zf-TRAF_2 PF15965.5 PIK55863.1 - 1.7e-21 76.5 16.5 2.8e-21 75.8 16.5 1.3 1 0 0 1 1 1 1 TRAF-like zinc-finger F-box_4 PF15966.5 PIK55863.1 - 4.1e-13 49.2 0.2 4.1e-13 49.2 0.2 1.7 2 0 0 2 2 2 1 F-box F-box PF00646.33 PIK55863.1 - 3.8e-05 23.4 0.9 7.6e-05 22.5 0.9 1.5 1 0 0 1 1 1 1 F-box domain zf-TRAF PF02176.18 PIK55863.1 - 0.0049 17.5 9.0 0.0049 17.5 9.0 1.8 2 0 0 2 2 2 1 TRAF-type zinc finger F-box-like PF12937.7 PIK55863.1 - 0.022 14.6 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like Erf4 PF10256.9 PIK55864.1 - 1.4e-27 96.1 0.0 2.5e-27 95.3 0.0 1.4 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family Stn1_C PF12659.7 PIK55864.1 - 0.12 12.4 0.6 0.66 9.9 0.1 2.1 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH Syja_N PF02383.18 PIK55865.1 - 1.7e-09 37.5 0.1 2.5e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain Syja_N PF02383.18 PIK55866.1 - 2.2e-48 165.3 0.0 2.9e-48 164.8 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF4518 PF15008.6 PIK55866.1 - 0.012 14.8 0.7 0.014 14.5 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) eRF1_2 PF03464.15 PIK55867.1 - 6.5e-23 81.5 0.1 1e-15 58.2 0.0 2.3 1 1 1 2 2 2 2 eRF1 domain 2 eRF1_3 PF03465.15 PIK55867.1 - 4.2e-22 78.8 0.1 7.4e-22 78.0 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 3 acVLRF1 PF18859.1 PIK55867.1 - 0.00028 21.2 0.0 0.00045 20.5 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor TPR_1 PF00515.28 PIK55868.1 - 8.7e-16 57.0 2.6 9.9e-06 25.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK55868.1 - 8.3e-15 53.7 1.0 0.00034 20.6 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK55868.1 - 1.8e-14 52.6 7.2 0.00011 22.1 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat RRM_1 PF00076.22 PIK55868.1 - 2.3e-12 46.6 0.0 1.7e-11 43.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_16 PF13432.6 PIK55868.1 - 1.4e-09 38.4 0.3 6.3e-05 23.5 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK55868.1 - 7.5e-09 35.1 2.4 5e-05 22.9 0.0 3.5 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 PIK55868.1 - 2.9e-05 24.5 0.7 0.00071 20.0 0.0 3.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55868.1 - 3.8e-05 24.1 0.9 0.049 14.5 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK55868.1 - 0.00012 22.3 1.1 0.029 14.6 0.3 2.7 1 1 0 2 2 2 1 Tetratricopeptide repeat Spt20 PF12090.8 PIK55868.1 - 0.0012 18.6 15.4 0.0012 18.6 15.4 4.0 2 1 0 2 2 1 1 Spt20 family TPR_7 PF13176.6 PIK55868.1 - 0.004 17.1 1.1 1 9.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat RRM_occluded PF16842.5 PIK55868.1 - 0.0051 16.6 0.0 0.019 14.8 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif TPR_9 PF13371.6 PIK55868.1 - 0.019 15.1 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK55868.1 - 0.02 14.7 1.6 11 6.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK55868.1 - 0.027 15.1 2.2 21 6.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK55868.1 - 0.049 13.9 0.1 0.14 12.4 0.1 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 PIK55868.1 - 0.054 13.9 0.5 4.1 8.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK55868.1 - 0.14 12.2 0.0 0.14 12.2 0.0 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF4692 PF15763.5 PIK55869.1 - 1.1 9.7 6.0 0.34 11.4 2.4 1.8 1 1 1 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Cpn60_TCP1 PF00118.24 PIK55870.1 - 1.2e-43 149.5 1.7 1.4e-43 149.3 1.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Death PF00531.22 PIK55871.1 - 6.1e-12 45.5 0.4 1.5e-11 44.3 0.4 1.6 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK55871.1 - 1.3e-10 41.4 0.2 2.4e-10 40.6 0.2 1.4 1 0 0 1 1 1 1 ZU5 domain DRIM PF07539.12 PIK55872.1 - 1.2e-148 496.3 8.7 1.2e-148 496.3 8.7 4.3 5 0 0 5 5 5 1 Down-regulated in metastasis HEAT PF02985.22 PIK55872.1 - 8.7e-05 22.5 6.1 0.82 10.1 0.1 7.7 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 PIK55872.1 - 0.0004 20.7 2.2 0.51 10.8 0.1 5.4 5 0 0 5 5 5 1 HEAT repeats BssS PF13991.6 PIK55872.1 - 0.06 13.4 0.0 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 BssS protein family F-box-like PF12937.7 PIK55873.1 - 2.2e-05 24.2 2.7 0.00025 20.9 0.1 3.1 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 PIK55873.1 - 0.0047 16.5 0.2 0.012 15.2 0.2 1.6 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 PIK55873.1 - 0.09 13.2 25.0 2.4 8.7 5.9 6.0 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) NOD PF06816.13 PIK55873.1 - 0.1 12.2 0.3 4.6 6.9 0.1 3.0 3 0 0 3 3 3 0 NOTCH protein LRR_8 PF13855.6 PIK55874.1 - 3.6e-47 158.0 45.1 3.9e-14 52.2 0.7 4.8 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 PIK55874.1 - 1.1e-15 57.7 6.0 4.5e-10 39.6 0.4 2.7 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK55874.1 - 8.7e-13 48.2 25.0 0.00021 21.6 2.3 5.4 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK55874.1 - 3.9e-08 33.0 9.3 0.0029 17.1 1.2 3.4 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK55874.1 - 2.1e-06 27.5 18.2 2.2 9.2 0.0 8.1 7 2 1 8 8 8 3 Leucine Rich Repeat Pox_EPC_I2-L1 PF12575.8 PIK55874.1 - 0.034 14.4 0.3 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DED PF01335.21 PIK55875.1 - 1.7e-17 63.5 0.7 3.4e-17 62.5 0.7 1.5 1 0 0 1 1 1 1 Death effector domain FKBP_C PF00254.28 PIK55877.1 - 4.2e-19 68.7 0.0 9.4e-19 67.5 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.6 PIK55877.1 - 2.4e-06 27.1 0.6 0.096 12.4 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 PIK55877.1 - 0.00023 21.0 0.5 0.17 12.1 0.4 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK55877.1 - 0.0036 17.8 0.3 1.8 9.1 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK55877.1 - 0.0054 16.5 1.5 3.3 7.7 0.6 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK55877.1 - 0.17 12.8 0.1 1 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Phospholip_A2_2 PF05826.12 PIK55878.1 - 4.8e-32 110.1 1.9 1.4e-31 108.6 1.9 1.8 1 0 0 1 1 1 1 Phospholipase A2 adh_short PF00106.25 PIK55879.1 - 8.4e-29 100.4 0.0 2.1e-28 99.1 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK55879.1 - 4.7e-21 75.4 0.0 1.1e-20 74.3 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK55879.1 - 0.0027 17.7 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 KR domain RT_RNaseH_2 PF17919.1 PIK55880.1 - 5.7e-32 109.7 0.0 1.1e-31 108.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK55880.1 - 2.8e-29 101.5 0.0 5.8e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK55880.1 - 3e-28 98.9 0.0 5.3e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK55880.1 - 1.5e-18 66.6 0.7 3.5e-18 65.4 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVP PF00077.20 PIK55880.1 - 5e-05 23.5 0.0 0.00018 21.8 0.0 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 PIK55880.1 - 0.00028 21.1 0.0 0.00078 19.6 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DUF4722 PF15849.5 PIK55880.1 - 0.0036 17.0 0.0 0.0083 15.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4722) gag-asp_proteas PF13975.6 PIK55880.1 - 0.0042 17.6 0.0 0.011 16.2 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK55880.1 - 0.052 14.2 0.0 0.18 12.5 0.0 2.0 1 0 0 1 1 1 0 Aspartyl protease TPT PF03151.16 PIK55882.1 - 1.6e-80 270.6 17.9 1.9e-80 270.4 17.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 PIK55882.1 - 6.3e-11 42.6 25.4 7.7e-06 26.1 7.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 PIK55882.1 - 5.1e-08 32.5 19.0 6.8e-08 32.1 19.0 1.1 1 0 0 1 1 1 1 UAA transporter family DUF1129 PF06570.11 PIK55882.1 - 0.83 9.1 3.4 0.33 10.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) TRAP-gamma PF07074.12 PIK55883.1 - 7.9e-69 230.6 6.7 9.1e-69 230.4 6.7 1.0 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF3007 PF11460.8 PIK55883.1 - 0.0026 18.0 0.2 0.0044 17.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3007) SpoIIM PF01944.17 PIK55883.1 - 0.003 17.6 0.4 0.0063 16.6 0.1 1.6 2 0 0 2 2 2 1 Stage II sporulation protein M SieB PF14163.6 PIK55883.1 - 0.014 14.9 0.6 0.014 14.9 0.6 2.1 2 0 0 2 2 2 0 Super-infection exclusion protein B FxsA PF04186.13 PIK55883.1 - 0.093 12.9 0.2 0.093 12.9 0.2 1.5 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein CHDNT PF08073.12 PIK55884.1 - 1.3e-22 79.5 0.1 4.1e-22 77.9 0.1 1.9 1 0 0 1 1 1 1 CHDNT (NUC034) domain SURF2 PF05477.11 PIK55884.1 - 0.0091 15.7 6.0 0.014 15.1 6.0 1.2 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) ABC_trans_N PF14510.6 PIK55884.1 - 5.9 7.6 8.7 0.37 11.4 3.5 1.7 2 0 0 2 2 2 0 ABC-transporter N-terminal PHD PF00628.29 PIK55885.1 - 2.2e-23 81.9 26.8 8.5e-12 44.8 5.5 2.9 3 0 0 3 3 3 2 PHD-finger Chromo PF00385.24 PIK55885.1 - 7e-17 61.1 0.1 1e-12 47.8 0.0 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PHD_2 PF13831.6 PIK55885.1 - 0.00072 19.1 9.9 0.14 11.8 2.6 3.1 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 PIK55885.1 - 0.026 14.1 10.0 0.5 10.0 1.0 3.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Rubredoxin PF00301.20 PIK55885.1 - 0.48 10.5 9.6 4.9 7.2 0.4 3.2 2 0 0 2 2 2 0 Rubredoxin C1_1 PF00130.22 PIK55885.1 - 3.7 7.5 19.6 1.7 8.6 1.4 3.6 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RP-C_C PF11800.8 PIK55885.1 - 3.9 7.5 8.2 14 5.7 0.5 2.5 2 0 0 2 2 2 0 Replication protein C C-terminal region SNF2_N PF00176.23 PIK55886.1 - 2.6e-56 190.9 0.0 4.2e-56 190.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1086 PF06461.11 PIK55886.1 - 2.3e-51 173.3 0.0 6.1e-51 171.9 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF1087 PF06465.13 PIK55886.1 - 2.6e-28 97.8 4.8 8.1e-28 96.2 4.8 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.31 PIK55886.1 - 1.1e-20 74.1 0.0 2.3e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK55886.1 - 2.2e-06 27.8 0.0 7.6e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 PIK55886.1 - 2.8e-06 26.7 0.0 1.4e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 PIK55886.1 - 0.006 16.9 0.4 0.025 14.9 0.0 2.4 2 1 1 3 3 3 1 AAA domain DEAD PF00270.29 PIK55886.1 - 0.13 12.0 0.1 0.5 10.1 0.1 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase CHDCT2 PF08074.11 PIK55887.1 - 5.1e-05 23.5 1.7 5.1e-05 23.5 1.7 2.7 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain DUF2967 PF11179.8 PIK55888.1 - 0.12 10.5 0.2 0.14 10.2 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) MMR_HSR1 PF01926.23 PIK55889.1 - 1.5e-07 31.5 0.1 2.7e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK55889.1 - 0.0063 16.6 0.2 0.021 14.9 0.0 1.8 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 PIK55889.1 - 0.01 15.4 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AIG1 PF04548.16 PIK55889.1 - 0.059 12.7 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 PIK55889.1 - 0.097 12.6 0.2 0.19 11.6 0.0 1.5 2 1 0 2 2 2 0 RsgA GTPase Ssu72 PF04722.13 PIK55891.1 - 7.1e-46 156.2 1.0 9.1e-46 155.8 1.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein HECW1_helix PF18436.1 PIK55891.1 - 0.0023 18.0 0.1 0.0046 17.0 0.1 1.5 1 0 0 1 1 1 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 WD40 PF00400.32 PIK55892.1 - 2.6e-34 116.7 20.7 7.3e-07 29.8 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55892.1 - 4.6e-14 52.5 0.6 0.051 13.9 0.0 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK55892.1 - 0.0061 15.6 0.0 1.5 7.7 0.0 2.6 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Borrelia_P83 PF05262.11 PIK55892.1 - 0.032 12.7 9.2 0.045 12.2 9.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4407 PF14362.6 PIK55892.1 - 0.77 9.1 2.7 1.2 8.4 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MCM_bind PF09739.9 PIK55892.1 - 2 6.7 8.4 3 6.2 8.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PA26 PF04636.13 PIK55892.1 - 3.8 6.3 7.2 6.1 5.6 7.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Cyt-b5 PF00173.28 PIK55893.1 - 1.3e-08 34.8 0.0 2.6e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rad60-SLD PF11976.8 PIK55893.1 - 0.066 13.0 0.5 0.18 11.7 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like CRAL_TRIO_N PF03765.15 PIK55893.1 - 0.18 12.0 0.8 2.5 8.3 0.0 2.3 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain DnaJ PF00226.31 PIK55894.1 - 1e-23 83.2 0.1 2.2e-23 82.1 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 PIK55894.1 - 0.011 15.8 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin Wound_ind PF08186.11 PIK55894.1 - 0.14 12.6 0.1 0.6 10.6 0.1 2.1 1 0 0 1 1 1 0 Wound-inducible basic protein family EF-hand_1 PF00036.32 PIK55895.1 - 1.1e-22 77.9 0.5 0.0011 18.4 0.1 6.2 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 PIK55895.1 - 9.2e-18 64.5 7.8 7.2e-08 32.8 0.3 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 PIK55895.1 - 6.5e-16 56.8 1.2 0.0093 15.8 0.1 6.1 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 PIK55895.1 - 4.9e-12 45.5 7.0 0.045 13.6 0.0 5.7 6 0 0 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 PIK55895.1 - 2.1e-10 39.6 5.3 0.044 13.3 0.0 5.6 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 PIK55895.1 - 2.4e-05 24.6 7.4 0.81 10.0 1.3 3.4 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK55895.1 - 0.0015 18.5 4.3 0.23 11.4 0.4 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand UQ_con PF00179.26 PIK55896.1 - 9.5e-20 70.7 0.1 1.4e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK55896.1 - 0.083 12.6 0.1 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic E2 family B SH2 PF00017.24 PIK55897.1 - 7.4e-41 138.1 0.0 1.4e-23 82.8 0.0 2.1 2 0 0 2 2 2 2 SH2 domain SH2_2 PF14633.6 PIK55897.1 - 0.0022 17.4 0.0 0.41 10.0 0.0 2.2 2 0 0 2 2 2 2 SH2 domain Ant_C PF05586.11 PIK55897.1 - 0.042 14.5 0.0 0.18 12.4 0.0 2.0 2 1 0 2 2 2 0 Anthrax receptor C-terminus region p450 PF00067.22 PIK55898.1 - 2.6e-103 346.3 0.0 3e-103 346.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Propep_M14 PF02244.16 PIK55898.1 - 0.23 11.9 1.2 0.99 9.8 0.2 2.5 3 0 0 3 3 3 0 Carboxypeptidase activation peptide p450 PF00067.22 PIK55899.1 - 3.2e-103 346.0 0.0 3.8e-103 345.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Propep_M14 PF02244.16 PIK55899.1 - 0.28 11.6 1.3 1.1 9.7 0.2 2.4 3 0 0 3 3 3 0 Carboxypeptidase activation peptide p450 PF00067.22 PIK55900.1 - 6.7e-104 348.2 0.0 7.5e-104 348.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 PIK55901.1 - 4.8e-19 68.8 0.0 6e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 PIK55901.1 - 4.6e-07 29.2 0.0 0.00035 19.7 0.0 2.3 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_8 PF13450.6 PIK55901.1 - 0.016 15.4 0.1 0.034 14.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_65C PF03633.15 PIK55901.1 - 0.82 9.6 0.0 0.82 9.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain B9-C2 PF07162.11 PIK55902.1 - 1.1e-49 168.9 0.0 1.3e-49 168.6 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein 7tm_1 PF00001.21 PIK55903.1 - 7.5e-47 159.9 28.5 9.2e-47 159.6 28.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55903.1 - 7.8e-11 42.1 21.2 7.8e-11 42.1 21.2 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55903.1 - 3.3e-10 39.8 29.9 4.2e-10 39.4 29.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK55903.1 - 2.6e-07 30.3 19.9 2.6e-07 30.3 19.9 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK55903.1 - 0.00015 21.6 20.3 0.00025 20.9 20.3 1.3 1 1 0 1 1 1 1 Olfactory receptor Srg PF02118.21 PIK55903.1 - 0.0019 17.9 27.4 0.02 14.5 27.6 2.0 1 1 1 2 2 2 1 Srg family chemoreceptor Pkinase_Tyr PF07714.17 PIK55904.1 - 0.0065 15.8 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 PIK55905.1 - 7.1e-46 154.7 0.2 1.6e-21 76.5 0.1 2.7 2 0 0 2 2 2 2 C2 domain Pkinase_Tyr PF07714.17 PIK55905.1 - 2e-34 119.1 0.3 3.5e-34 118.3 0.3 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK55905.1 - 5.5e-16 58.7 0.2 1e-15 57.9 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain GET2 PF08690.10 PIK55905.1 - 0.4 10.3 5.7 0.94 9.1 5.7 1.6 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4693 PF15764.5 PIK55906.1 - 7.3e-18 65.1 8.0 1e-16 61.4 8.0 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4693) DWNN PF08783.11 PIK55908.1 - 1.9e-28 98.5 0.6 4.3e-28 97.4 0.6 1.6 1 0 0 1 1 1 1 DWNN domain zf-CCHC PF00098.23 PIK55908.1 - 1.1e-06 28.5 0.4 4.6e-06 26.5 0.4 2.2 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 PIK55908.1 - 5.7e-06 26.1 11.4 5.7e-06 26.1 11.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 PIK55908.1 - 8.5e-05 22.7 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-CCHC_2 PF13696.6 PIK55908.1 - 0.00014 21.6 1.7 0.00014 21.6 1.7 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-RING_2 PF13639.6 PIK55908.1 - 0.00015 22.0 10.6 0.00015 22.0 10.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK55908.1 - 0.0002 21.1 10.2 0.0002 21.1 10.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK55908.1 - 0.001 19.0 10.2 0.001 19.0 10.2 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK55908.1 - 0.021 14.7 11.5 0.021 14.7 11.5 1.8 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK55908.1 - 0.4 10.9 15.2 0.11 12.6 11.5 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 PIK55908.1 - 1.4 8.7 11.8 0.82 9.5 8.6 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 PIK55908.1 - 6.1 7.0 15.5 9.7 6.3 7.5 3.0 2 2 0 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.6 PIK55908.1 - 6.7 6.7 17.5 0.14 12.0 10.1 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 ADP_ribosyl_GH PF03747.14 PIK55910.1 - 3.1e-52 178.1 0.0 3.9e-52 177.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Titin_Ig-rpts PF06582.12 PIK55912.1 - 0.058 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Titin repeat DUF1759 PF03564.15 PIK55914.1 - 7.6e-06 25.9 0.1 1.5e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) gag-asp_proteas PF13975.6 PIK55915.1 - 0.00099 19.6 0.0 0.0025 18.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK55915.1 - 0.0013 19.3 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 PIK55915.1 - 0.014 15.2 0.0 0.028 14.2 0.0 1.5 1 1 0 1 1 1 0 Putative peptidase (DUF1758) RVT_1 PF00078.27 PIK55915.1 - 0.087 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK55916.1 - 3.5e-58 196.2 0.0 5.5e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase DNA_pol_viral_C PF00336.18 PIK55916.1 - 0.05 13.0 0.1 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain RVT_1 PF00078.27 PIK55917.1 - 2.7e-15 56.5 0.1 4.3e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK55917.1 - 4.7e-10 38.9 1.3 1.1e-09 37.7 1.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) RNA_pol_Rbc25 PF08292.12 PIK55918.1 - 0.038 14.2 0.2 40 4.5 0.0 4.5 2 2 5 7 7 7 0 RNA polymerase III subunit Rpc25 DUF1736 PF08409.11 PIK55918.1 - 0.079 13.0 25.3 8.9 6.4 0.1 9.2 1 1 10 11 11 11 0 Domain of unknown function (DUF1736) DUF5529 PF17669.1 PIK55918.1 - 0.22 11.5 2.5 8.9 6.3 0.2 3.7 1 1 3 4 4 4 0 Family of unknown function (DUF5529) FAM150 PF15129.6 PIK55918.1 - 0.46 10.7 13.5 27 4.9 0.6 5.4 1 1 5 6 6 6 0 FAM150 family DUF4116 PF13475.6 PIK55918.1 - 2.2 8.1 6.1 2.5e+02 1.5 0.0 6.5 10 2 1 11 11 11 0 Domain of unknown function (DUF4116) DNA_pol_B_2 PF03175.13 PIK55919.1 - 1.4e-12 47.3 1.2 2.9e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral Plus-3 PF03126.18 PIK55919.1 - 0.032 14.8 0.4 0.12 12.9 0.0 2.1 2 1 0 2 2 2 0 Plus-3 domain RVT_1 PF00078.27 PIK55924.1 - 1.7e-10 40.8 0.0 2.8e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Myosin_head PF00063.21 PIK55925.1 - 1.5e-28 99.5 0.0 1.9e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 PIK55925.1 - 2.9e-05 24.5 0.0 5.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK55925.1 - 0.0037 17.5 0.0 0.0079 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Torsin PF06309.11 PIK55925.1 - 0.014 15.5 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Torsin Kinesin PF00225.23 PIK55925.1 - 0.028 13.4 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 Kinesin motor domain DUF87 PF01935.17 PIK55925.1 - 0.07 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Microtub_bd PF16796.5 PIK55925.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding RNA_helicase PF00910.22 PIK55925.1 - 0.12 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF218 PF02698.17 PIK55925.1 - 0.16 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 DUF218 domain rve PF00665.26 PIK55926.1 - 2.3e-12 47.2 0.0 4.6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK55926.1 - 6.8e-06 26.1 0.8 2.9e-05 24.1 0.4 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK55926.1 - 0.022 15.0 1.9 0.048 13.9 1.9 1.6 1 0 0 1 1 1 0 H2C2 zinc finger DUF585 PF04522.12 PIK55926.1 - 0.059 13.0 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF585) DUF3110 PF11360.8 PIK55926.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) Sulfatase PF00884.23 PIK55928.1 - 1.6e-35 123.0 0.0 1.9e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK55928.1 - 0.0011 19.7 0.0 0.0021 18.8 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF229 PF02995.17 PIK55928.1 - 0.15 10.6 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Sulfatase PF00884.23 PIK55929.1 - 7.3e-30 104.4 0.0 8.8e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Sulfatase IATP PF04568.12 PIK55930.1 - 6e-22 77.9 3.9 7.7e-22 77.6 3.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP TMPIT PF07851.13 PIK55930.1 - 0.7 9.1 2.3 0.75 9.0 2.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein CREPT PF16566.5 PIK55930.1 - 1.4 9.1 6.9 1.7 8.8 6.9 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4337 PF14235.6 PIK55930.1 - 1.5 8.9 6.8 1.8 8.6 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Somatomedin_B PF01033.17 PIK55931.1 - 0.011 16.2 13.3 0.011 16.2 13.3 3.8 4 0 0 4 4 4 0 Somatomedin B domain Phage_CP76 PF06892.11 PIK55931.1 - 0.068 12.7 1.0 0.13 11.8 1.0 1.4 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) MscS_porin PF12795.7 PIK55931.1 - 0.23 11.0 2.9 0.34 10.4 2.9 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CENP-F_leu_zip PF10473.9 PIK55931.1 - 0.55 10.3 6.5 0.99 9.4 6.5 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sec3_C PF09763.9 PIK55931.1 - 0.96 7.8 4.3 1.4 7.2 4.3 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 TolA_bind_tri PF16331.5 PIK55931.1 - 2.1 8.5 11.8 0.18 11.9 7.2 1.6 2 0 0 2 2 2 0 TolA binding protein trimerisation Sushi PF00084.20 PIK55932.1 - 6.4e-22 77.9 6.9 1.8e-10 41.2 0.4 2.0 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.22 PIK55932.1 - 1.9e-05 24.9 4.6 0.014 15.7 0.5 2.2 2 0 0 2 2 2 2 Hormone receptor domain cEGF PF12662.7 PIK55932.1 - 0.0092 15.9 3.7 0.68 9.9 0.3 2.6 2 0 0 2 2 2 2 Complement Clr-like EGF-like Sushi PF00084.20 PIK55933.1 - 3.2e-07 30.9 9.8 0.0067 17.0 0.3 3.3 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Amidase02_C PF12123.8 PIK55933.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase Orf78 PF06024.12 PIK55934.1 - 1.5 9.1 3.9 1.8 8.9 0.0 2.8 3 1 0 3 3 3 0 Orf78 (ac78) FXa_inhibition PF14670.6 PIK55934.1 - 7.2 7.0 10.7 19 5.7 10.7 1.7 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site zf-CCHC PF00098.23 PIK55935.1 - 1.4e-06 28.1 22.3 0.00028 20.8 0.2 4.7 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK55935.1 - 0.0025 17.7 16.0 0.08 12.9 1.0 3.9 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK55935.1 - 0.0032 17.2 11.1 2.1 8.1 0.3 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55935.1 - 0.0096 15.7 0.2 0.0096 15.7 0.2 3.9 4 0 0 4 4 4 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK55935.1 - 0.0097 15.6 0.8 0.0097 15.6 0.8 2.7 1 1 1 2 2 2 1 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK55935.1 - 0.21 11.4 20.7 0.23 11.3 6.2 3.7 4 0 0 4 4 4 0 Zinc knuckle zf-RVT PF13966.6 PIK55937.1 - 1.9e-07 31.7 0.6 3.7e-07 30.8 0.6 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase NACHT PF05729.12 PIK55939.1 - 4.6e-15 55.9 0.0 7.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK55939.1 - 0.00014 21.8 0.1 0.42 10.7 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain AAA_25 PF13481.6 PIK55939.1 - 0.0012 18.4 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain EphA2_TM PF14575.6 PIK55939.1 - 0.023 15.6 0.3 0.047 14.6 0.3 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AAA_22 PF13401.6 PIK55939.1 - 0.035 14.4 0.0 0.077 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK55939.1 - 0.086 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Adeno_E3_CR2 PF02439.15 PIK55939.1 - 0.091 12.5 3.4 0.2 11.5 3.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NB-ARC PF00931.22 PIK55939.1 - 0.092 11.9 0.0 0.23 10.6 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain V-set PF07686.17 PIK55939.1 - 0.16 12.1 3.2 15 5.8 0.1 3.8 4 0 0 4 4 4 0 Immunoglobulin V-set domain LapA_dom PF06305.11 PIK55939.1 - 0.19 11.6 0.6 0.43 10.4 0.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain KCNQ_channel PF03520.14 PIK55940.1 - 1.1e-31 110.1 0.1 2.1e-31 109.2 0.1 1.4 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.31 PIK55940.1 - 5e-18 65.2 0.1 7e-18 64.7 0.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK55940.1 - 4.2e-12 45.9 2.2 7.3e-12 45.1 2.2 1.3 1 0 0 1 1 1 1 Ion channel Lig_chan PF00060.26 PIK55940.1 - 0.0093 15.8 0.4 0.051 13.4 0.2 2.2 1 1 1 2 2 2 1 Ligand-gated ion channel RVT_1 PF00078.27 PIK55941.1 - 2.7e-39 135.0 0.1 4.4e-39 134.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK55941.1 - 7.8e-09 35.4 0.1 2.3e-07 30.6 0.0 3.0 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK55941.1 - 1.1e-07 31.6 0.1 2.8e-07 30.3 0.1 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1409 PF07197.12 PIK55941.1 - 0.1 12.5 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) SRCR PF00530.18 PIK55942.1 - 2.5e-20 72.8 0.5 2.1e-10 41.0 0.0 3.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain 7tm_2 PF00002.24 PIK55942.1 - 5.7e-15 55.3 16.8 9.2e-15 54.6 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK55942.1 - 1.4e-08 34.9 16.2 5.5e-08 33.1 16.2 2.1 1 0 0 1 1 1 1 Somatomedin B domain SRCR_2 PF15494.6 PIK55942.1 - 3.9e-08 33.7 1.2 0.0031 18.0 0.0 3.3 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain 7tm_1 PF00001.21 PIK55943.1 - 1.3e-40 139.4 19.5 1.9e-40 138.9 19.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55943.1 - 6.6e-10 39.1 23.4 6.6e-10 39.1 23.4 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55943.1 - 5e-08 32.6 21.1 6.3e-08 32.3 21.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SF1-HH PF16275.5 PIK55945.1 - 4.6e-36 123.6 0.5 4.6e-36 123.6 0.5 2.6 3 0 0 3 3 3 1 Splicing factor 1 helix-hairpin domain zf-CCHC_3 PF13917.6 PIK55945.1 - 0.01 15.7 6.8 0.88 9.6 2.7 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK55945.1 - 0.027 14.3 3.5 5.3 7.0 0.3 3.0 2 0 0 2 2 2 0 Zinc knuckle KH_1 PF00013.29 PIK55945.1 - 0.034 14.0 1.0 0.082 12.8 1.0 1.6 1 1 0 1 1 1 0 KH domain Prok-RING_1 PF14446.6 PIK55945.1 - 0.27 11.2 4.2 0.86 9.6 0.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-CCHC PF00098.23 PIK55945.1 - 0.33 11.1 7.6 4.6 7.5 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK55945.1 - 1.9 8.4 5.1 2.5 8.0 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK55945.1 - 2 8.2 6.0 17 5.2 0.0 3.5 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 PIK55945.1 - 4.3 7.2 6.0 3.7 7.4 0.7 2.3 2 0 0 2 2 2 0 Zinc knuckle 7tm_1 PF00001.21 PIK55946.1 - 4.9e-42 144.1 20.7 7.1e-42 143.5 20.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55946.1 - 3.9e-12 46.3 15.5 5.2e-12 45.9 14.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK55946.1 - 7.3e-08 32.1 8.3 8.2e-08 31.9 7.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK55946.1 - 1.8e-07 30.8 16.6 2.3e-07 30.5 16.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK55947.1 - 2.1e-43 148.6 19.7 3e-43 148.0 19.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK55947.1 - 1.6e-12 47.6 14.6 2.4e-12 47.1 14.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK55947.1 - 4.7e-09 36.0 15.9 6e-09 35.7 15.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK55947.1 - 6.7e-08 32.2 6.6 9.6e-08 31.7 6.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv HYR PF02494.16 PIK55948.1 - 9.2e-42 141.3 14.1 7.1e-16 58.3 0.5 3.9 4 0 0 4 4 4 3 HYR domain Sushi PF00084.20 PIK55948.1 - 0.00033 21.2 1.3 0.00075 20.1 0.3 2.3 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK55948.1 - 0.0015 19.1 0.1 0.045 14.4 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain DUF5011 PF16403.5 PIK55948.1 - 0.026 14.6 0.4 1.5 9.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Cadherin_5 PF17892.1 PIK55948.1 - 3.4 7.7 5.2 2 8.5 0.1 3.1 4 0 0 4 4 4 0 Cadherin-like domain 7tm_2 PF00002.24 PIK55950.1 - 5.8e-37 127.3 23.8 5.8e-37 127.3 23.8 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK55950.1 - 5.8e-15 55.6 3.7 1.2e-14 54.5 3.7 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Phage_holin_3_7 PF05449.11 PIK55950.1 - 0.11 12.5 0.1 0.11 12.5 0.1 4.6 6 0 0 6 6 6 0 Putative 3TM holin, Phage_holin_3 Trypsin PF00089.26 PIK55951.1 - 4.9e-47 160.6 0.2 9.9e-47 159.6 0.2 1.5 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 PIK55951.1 - 2.5e-30 104.4 89.7 5.9e-09 36.0 12.0 6.5 5 2 2 7 7 7 5 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 PIK55951.1 - 2.5e-05 24.6 0.1 6e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK55951.1 - 8.1e-05 23.6 0.0 0.00021 22.2 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF4772 PF15997.5 PIK55952.1 - 2e-11 44.5 0.6 3.3e-10 40.6 0.1 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4772) Tudor_2 PF18104.1 PIK55952.1 - 5.2e-06 26.0 0.0 2.6e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain Tudor_3 PF18115.1 PIK55952.1 - 0.00054 19.7 0.0 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 PIK55952.1 - 0.0037 17.3 0.0 0.0084 16.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.10 PIK55952.1 - 0.023 14.6 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor zf-C2H2 PF00096.26 PIK55952.1 - 0.23 12.0 1.6 0.99 10.0 1.6 2.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type Peptidase_A17 PF05380.13 PIK55953.1 - 9.7e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase C2 PF00168.30 PIK55954.1 - 1.5e-32 112.0 0.0 3.7e-16 59.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 PIK55954.1 - 3.3e-15 56.3 11.1 7.2e-15 55.3 11.1 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ_6 PF17820.1 PIK55954.1 - 8.9e-13 47.9 0.0 2.2e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK55954.1 - 5.3e-07 29.9 0.1 1.3e-06 28.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK55954.1 - 0.0074 16.6 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Cytochrome_C7 PF14522.6 PIK55954.1 - 1.9 8.5 7.4 5.5 7.1 7.4 1.8 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c zf-piccolo PF05715.13 PIK55954.1 - 2.4 8.4 6.9 5.1 7.3 6.9 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger Phytochelatin_C PF09328.10 PIK55954.1 - 3.3 7.0 5.0 5.5 6.2 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) RIO1 PF01163.22 PIK55955.1 - 4.9e-50 169.7 0.6 1e-49 168.7 0.6 1.4 1 0 0 1 1 1 1 RIO1 family WD40 PF00400.32 PIK55956.1 - 3.9e-49 163.6 14.9 2.7e-08 34.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK55956.1 - 1e-09 38.6 0.1 0.11 12.8 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK55956.1 - 1.3e-08 34.9 0.1 6.1e-05 23.0 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK55956.1 - 2.1e-08 33.5 0.1 0.065 12.2 0.0 4.1 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 PIK55956.1 - 0.0073 16.2 0.1 20 5.3 0.1 3.9 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 PIK55956.1 - 0.018 14.4 0.1 6.8 5.9 0.0 3.0 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 PIK55956.1 - 0.092 12.1 0.6 0.34 10.2 0.3 1.8 1 1 0 1 1 1 0 WD40-like domain nos_propeller PF18764.1 PIK55956.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Nitrous oxide reductase propeller repeat RVT_1 PF00078.27 PIK55957.1 - 6.3e-19 68.4 0.0 1.3e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK55957.1 - 0.15 12.1 1.0 0.36 10.9 0.3 2.0 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase La PF05383.17 PIK55958.1 - 2.8e-20 72.1 1.0 4.8e-20 71.4 1.0 1.4 1 0 0 1 1 1 1 La domain PAM2 PF07145.15 PIK55958.1 - 0.013 15.1 0.1 0.031 14.0 0.1 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Fibrinogen_C PF00147.18 PIK55959.1 - 7.5e-96 320.2 15.7 1.2e-58 198.5 9.6 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK55959.1 - 0.00052 20.2 12.7 0.00052 20.2 12.7 1.9 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK55960.1 - 9.6e-90 300.2 19.6 1.9e-52 178.2 12.1 2.4 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55960.1 - 5.3e-06 26.3 3.0 5.3e-06 26.3 3.0 3.5 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK55960.1 - 1.3e-05 25.3 4.5 1.3e-05 25.3 4.5 3.2 3 0 0 3 3 3 2 EGF domain TIL PF01826.17 PIK55960.1 - 0.021 15.0 10.1 0.021 15.0 10.1 3.0 3 1 0 3 3 3 0 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK55960.1 - 2.2 8.4 12.0 0.58 10.3 3.0 3.1 2 1 0 2 2 2 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK55961.1 - 2.8e-82 275.8 12.1 2e-56 191.3 8.9 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK55961.1 - 4.6e-06 26.8 19.1 4.6e-06 26.8 19.1 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK55961.1 - 1.4e-05 24.9 3.9 1.4e-05 24.9 3.9 3.5 3 1 1 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK55961.1 - 0.00021 21.4 7.1 0.00021 21.4 7.1 3.4 3 0 0 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK55961.1 - 0.71 10.0 14.0 3.3 7.8 1.4 2.8 2 0 0 2 2 2 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK55962.1 - 9.3e-47 159.7 7.9 4.6e-46 157.4 5.0 2.1 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK55962.1 - 5e-06 26.6 4.2 5e-06 26.6 4.2 3.2 3 0 0 3 3 3 2 EGF domain TILa PF12714.7 PIK55962.1 - 7.6e-05 22.6 3.0 7.6e-05 22.6 3.0 3.4 1 1 2 3 3 3 1 TILa domain TIL PF01826.17 PIK55962.1 - 0.016 15.4 11.0 0.016 15.4 11.0 2.8 2 1 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain EGF PF00008.27 PIK55962.1 - 0.034 14.4 12.9 0.052 13.9 1.0 3.4 2 1 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK55962.1 - 5.2 7.2 14.6 2.4 8.3 2.9 3.1 2 1 0 2 2 2 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK55963.1 - 1.2e-64 218.2 12.2 7.6e-59 199.2 11.0 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK55963.1 - 2e-06 27.9 19.9 2e-06 27.9 19.9 2.4 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_Tenascin PF18720.1 PIK55963.1 - 0.0065 16.5 0.3 0.0065 16.5 0.3 3.3 2 1 0 2 2 2 1 Tenascin EGF domain TILa PF12714.7 PIK55963.1 - 0.0081 16.1 3.2 0.0081 16.1 3.2 3.5 3 1 1 4 4 4 2 TILa domain CFC PF09443.10 PIK55963.1 - 0.042 13.7 2.1 0.042 13.7 2.1 2.5 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) Fibrinogen_C PF00147.18 PIK55964.1 - 8e-93 310.3 23.2 3.2e-50 171.0 11.3 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK55964.1 - 1.4e-05 25.2 6.0 1.4e-05 25.2 6.0 3.7 4 0 0 4 4 4 1 EGF domain COLFI PF01410.18 PIK55964.1 - 0.00079 18.8 5.1 0.11 11.8 0.1 3.3 2 1 1 3 3 3 2 Fibrillar collagen C-terminal domain EB PF01683.18 PIK55964.1 - 0.37 11.1 18.7 1.1 9.6 5.6 3.0 2 0 0 2 2 2 0 EB module EGF PF00008.27 PIK55964.1 - 5.8 7.3 17.4 5 7.5 2.3 4.0 3 0 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK55965.1 - 2.6e-26 92.8 0.6 3.1e-26 92.6 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK55966.1 - 5.2e-45 153.9 1.0 5.2e-45 153.9 1.0 1.4 1 1 1 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK55966.1 - 2.5e-06 27.5 9.4 7.1e-06 26.1 9.4 1.8 1 0 0 1 1 1 1 EGF domain EGF_MSP1_1 PF12946.7 PIK55966.1 - 0.0058 16.7 6.4 0.0058 16.7 6.4 2.0 2 0 0 2 2 2 1 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK55966.1 - 0.052 13.9 8.2 0.15 12.4 8.2 1.8 1 0 0 1 1 1 0 EGF-like domain cEGF PF12662.7 PIK55966.1 - 2.8 7.9 12.7 0.35 10.8 7.1 2.4 2 1 0 2 2 2 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK55967.1 - 2.9e-64 216.9 5.4 2.9e-64 216.9 5.4 1.3 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK55967.1 - 3.6e-06 27.1 9.4 1.2e-05 25.3 9.4 2.0 1 0 0 1 1 1 1 EGF domain EGF_MSP1_1 PF12946.7 PIK55967.1 - 0.01 15.9 6.4 0.01 15.9 6.4 2.3 3 0 0 3 3 3 0 MSP1 EGF domain 1 cEGF PF12662.7 PIK55967.1 - 3.3 7.7 12.0 0.36 10.8 6.4 2.3 2 1 0 2 2 2 0 Complement Clr-like EGF-like rve PF00665.26 PIK55968.1 - 2.5e-25 89.0 0.0 7e-25 87.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK55968.1 - 8e-20 70.7 2.7 1.6e-19 69.7 2.7 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK55968.1 - 0.00012 21.8 0.0 0.00036 20.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DUF4504 PF14953.6 PIK55968.1 - 0.051 13.0 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) zf-H2C2 PF09337.10 PIK55968.1 - 0.35 11.1 2.4 0.79 10.0 2.4 1.7 1 0 0 1 1 1 0 H2C2 zinc finger RT_RNaseH PF17917.1 PIK55969.1 - 1.2e-35 121.9 0.1 1.8e-35 121.4 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK55969.1 - 8.6e-27 93.1 0.1 1.3e-26 92.5 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC_6 PF15288.6 PIK55970.1 - 0.00058 19.6 1.0 0.0012 18.6 1.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK55970.1 - 0.0019 18.2 2.2 0.0035 17.4 2.2 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF86 PF01934.17 PIK55970.1 - 0.018 14.9 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF86 SMODS PF18144.1 PIK55970.1 - 0.11 12.6 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Fibrinogen_C PF00147.18 PIK55971.1 - 6.6e-23 81.7 0.9 7.2e-23 81.6 0.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain zf-CCHC PF00098.23 PIK55972.1 - 0.01 15.8 15.0 0.039 14.0 2.8 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK55972.1 - 0.016 14.9 10.2 0.55 10.0 0.3 2.3 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK55972.1 - 2.9 7.8 12.1 0.42 10.5 0.2 2.8 1 1 1 2 2 2 0 Zinc knuckle Kelch_1 PF01344.25 PIK55973.1 - 1.1e-32 111.4 1.7 3.1e-12 45.9 0.1 5.1 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 PIK55973.1 - 6.8e-25 86.5 4.0 2e-08 34.2 0.0 5.9 4 2 2 6 6 6 3 Kelch motif BTB PF00651.31 PIK55973.1 - 2.7e-22 79.1 0.1 7.7e-21 74.4 0.1 2.7 2 1 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 PIK55973.1 - 7.2e-10 38.7 4.9 0.016 15.2 0.0 4.8 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK55973.1 - 1.4e-07 31.2 7.1 0.013 15.5 0.0 4.7 5 1 0 5 5 5 3 Kelch motif BACK PF07707.15 PIK55973.1 - 2.4e-07 30.8 0.1 5.7e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 PIK55973.1 - 2.5e-07 30.5 9.4 0.0028 17.6 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 PIK55973.1 - 5e-06 26.7 11.5 0.21 11.9 0.0 5.7 5 2 1 6 6 6 3 Galactose oxidase, central domain TMEM234 PF10639.9 PIK55974.1 - 5.7e-38 129.5 0.4 6.2e-38 129.4 0.4 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 PIK55974.1 - 0.0084 16.3 3.4 0.19 11.9 3.4 2.1 1 1 0 1 1 1 1 EamA-like transporter family GCM PF03615.15 PIK55975.1 - 1.4e-52 177.3 2.6 1.6e-51 173.9 2.6 2.3 1 1 0 1 1 1 1 GCM motif protein TIR_2 PF13676.6 PIK55977.1 - 2.4e-06 28.1 0.0 4.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 TIR domain SAM_2 PF07647.17 PIK55977.1 - 3.8e-05 23.7 0.2 7.1e-05 22.8 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK55977.1 - 0.00033 21.1 0.3 0.00058 20.3 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TIR PF01582.20 PIK55977.1 - 0.0014 18.5 1.5 0.0053 16.6 0.1 2.1 2 0 0 2 2 2 1 TIR domain PDEase_I PF00233.19 PIK55978.1 - 4.1e-77 259.1 1.5 6.6e-77 258.4 1.5 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Mito_fiss_reg PF05308.11 PIK55980.1 - 1.5e-17 64.6 0.1 1.5e-17 64.6 0.1 1.9 2 1 0 2 2 2 1 Mitochondrial fission regulator Mito_fiss_reg PF05308.11 PIK55981.1 - 7.7e-05 22.9 0.0 9.7e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator Arm PF00514.23 PIK55982.1 - 2.2e-07 30.7 0.2 7.4e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HMA PF00403.26 PIK55982.1 - 0.00015 22.2 0.9 0.00038 20.8 0.9 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain YopX PF09643.10 PIK55982.1 - 0.0056 16.7 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 YopX protein Phage_holin_6_1 PF09682.10 PIK55982.1 - 0.091 13.2 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Aa_trans PF01490.18 PIK55983.1 - 3.3e-73 246.7 29.5 3.8e-73 246.5 29.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Vut_1 PF02592.15 PIK55983.1 - 0.0089 16.4 4.7 0.0089 16.4 4.7 3.2 2 2 1 3 3 3 1 Putative vitamin uptake transporter UPF0139 PF03669.13 PIK55983.1 - 0.021 14.7 2.0 0.024 14.5 0.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) p450 PF00067.22 PIK55984.1 - 4.7e-111 371.8 0.0 5.4e-111 371.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fibrinogen_C PF00147.18 PIK55985.1 - 4.4e-54 183.6 4.5 5.6e-54 183.3 4.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55985.1 - 2.9e-05 24.0 9.0 2.9e-05 24.0 9.0 3.0 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK55985.1 - 0.00014 22.0 9.3 0.00014 22.0 9.3 4.4 4 1 1 5 5 5 1 EGF domain TIL PF01826.17 PIK55985.1 - 0.011 16.0 13.2 0.011 16.0 13.2 3.3 2 1 1 3 3 3 0 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK55986.1 - 8.3e-48 163.1 1.8 1.1e-47 162.6 1.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK55986.1 - 2.3e-05 24.3 9.1 2.3e-05 24.3 9.1 3.0 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK55986.1 - 0.00013 22.1 9.3 0.00013 22.1 9.3 4.5 4 1 1 5 5 5 1 EGF domain TIL PF01826.17 PIK55986.1 - 0.012 15.9 13.7 0.012 15.9 13.7 3.3 2 1 1 3 3 3 0 Trypsin Inhibitor like cysteine rich domain Destabilase PF05497.12 PIK55987.1 - 9.1e-27 93.7 0.2 1e-26 93.6 0.2 1.1 1 0 0 1 1 1 1 Destabilase Guanylate_kin PF00625.21 PIK55988.1 - 4.7e-26 91.6 0.4 3e-13 49.9 0.1 3.2 2 1 1 3 3 3 2 Guanylate kinase L27 PF02828.16 PIK55988.1 - 9.4e-11 41.3 0.0 7.9e-06 25.5 0.0 2.8 2 0 0 2 2 2 2 L27 domain SH3_2 PF07653.17 PIK55988.1 - 3.7e-10 39.3 0.2 1.6e-09 37.3 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain PDZ PF00595.24 PIK55988.1 - 3.4e-09 36.9 1.1 7.9e-09 35.8 1.1 1.6 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 PIK55988.1 - 1.6e-07 30.8 1.2 3.1e-06 26.7 0.0 2.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK55988.1 - 0.0002 21.1 0.1 0.00093 19.0 0.1 2.2 1 1 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 PIK55988.1 - 0.0029 17.9 0.1 0.012 15.9 0.1 2.1 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 PIK55988.1 - 0.045 13.7 0.1 1.1 9.3 0.1 2.8 2 1 0 2 2 2 0 Tricorn protease PDZ domain TRP PF06011.12 PIK55989.1 - 0.1 11.3 6.7 0.042 12.6 2.4 2.0 1 1 0 2 2 2 0 Transient receptor potential (TRP) ion channel DUF2207 PF09972.9 PIK55989.1 - 5.7 5.6 7.3 2.2 6.9 0.4 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) TRP PF06011.12 PIK55990.1 - 5.3 5.7 11.5 0.08 11.7 2.1 2.3 2 1 0 3 3 3 0 Transient receptor potential (TRP) ion channel LRR_8 PF13855.6 PIK55991.1 - 4.6e-69 228.1 71.4 2.3e-15 56.1 9.3 7.3 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 PIK55991.1 - 2.1e-28 98.9 6.6 1.2e-10 41.5 0.0 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK55991.1 - 7.6e-20 70.7 59.8 6.1e-05 23.3 5.1 8.4 4 3 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK55991.1 - 1.6e-10 40.8 20.3 0.0008 19.0 2.8 5.0 1 1 4 5 5 5 5 Leucine-rich repeat Ephrin_rec_like PF07699.13 PIK55991.1 - 1.9e-06 27.5 23.0 0.005 16.6 5.9 4.1 2 1 1 3 3 3 3 Putative ephrin-receptor like LRR_1 PF00560.33 PIK55991.1 - 0.025 15.1 47.0 0.056 14.0 0.1 11.6 13 2 0 13 13 13 0 Leucine Rich Repeat GIT_SHD PF08518.11 PIK55991.1 - 0.088 12.5 0.2 11 5.8 0.0 2.8 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT DUF4457 PF14652.6 PIK55991.1 - 0.093 12.0 0.3 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4457) NCD3G PF07562.14 PIK55991.1 - 0.49 10.4 26.7 1.2 9.1 0.2 4.1 4 0 0 4 4 4 0 Nine Cysteines Domain of family 3 GPCR Ank_2 PF12796.7 PIK55993.1 - 2.2e-37 127.5 1.2 7.7e-16 58.5 0.0 3.4 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK55993.1 - 4.5e-28 97.3 6.4 8.6e-08 32.6 0.1 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 PIK55993.1 - 4.3e-25 87.0 1.3 1.7e-05 25.1 0.2 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 PIK55993.1 - 1.5e-23 80.3 0.4 2.1e-05 24.5 0.2 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK55993.1 - 2.5e-22 78.6 3.6 2.1e-09 37.4 0.1 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 PIK55993.1 - 8e-10 38.9 2.4 1.5e-09 38.0 2.4 1.5 1 0 0 1 1 1 1 SOCS box CCDC14 PF15254.6 PIK55995.1 - 2.2e-23 82.9 52.2 4.5e-20 72.0 37.4 2.7 2 1 0 2 2 2 2 Coiled-coil domain-containing protein 14 zf-3CxxC_2 PF17180.4 PIK55995.1 - 9.5 7.0 7.3 1.1 10.0 1.1 2.7 2 1 0 2 2 2 0 Zinc-binding domain FA_desaturase PF00487.24 PIK55996.1 - 4.2e-32 112.0 21.4 6.4e-32 111.4 21.4 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 PIK55996.1 - 4.4e-24 84.4 0.1 8.4e-24 83.5 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Voltage_CLC PF00654.20 PIK55996.1 - 0.03 13.6 0.6 0.051 12.8 0.6 1.3 1 0 0 1 1 1 0 Voltage gated chloride channel Cyclin_N PF00134.23 PIK55997.1 - 4.5e-13 49.0 0.4 4.5e-13 49.0 0.4 2.1 2 1 1 3 3 3 1 Cyclin, N-terminal domain Cyclin PF08613.11 PIK55997.1 - 2.1e-10 41.2 1.9 5.1e-10 39.9 0.8 2.3 2 1 0 2 2 2 1 Cyclin MukF_C PF17193.4 PIK55997.1 - 0.088 13.0 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 MukF C-terminal domain zf-C2H2 PF00096.26 PIK55998.1 - 2.8e-18 65.2 54.2 0.00057 20.2 4.3 7.5 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55998.1 - 4.8e-13 48.7 51.6 0.0088 16.8 3.5 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK55998.1 - 2.4e-07 30.9 46.2 0.16 12.5 0.2 7.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK55998.1 - 0.0057 16.9 1.8 0.0057 16.9 1.8 6.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding PHF5 PF03660.14 PIK55998.1 - 0.016 15.4 3.9 0.016 15.4 3.9 3.4 2 1 1 3 3 3 0 PHF5-like protein zf-C2H2_6 PF13912.6 PIK55998.1 - 0.038 14.0 0.4 0.038 14.0 0.4 5.2 6 0 0 6 6 6 0 C2H2-type zinc finger zf-met PF12874.7 PIK55998.1 - 0.19 12.2 42.8 0.12 12.8 2.7 6.7 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 PIK55998.1 - 0.79 9.5 34.5 0.065 13.0 1.2 5.7 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 PIK55999.1 - 1.3e-36 123.3 62.3 3.7e-09 36.6 3.8 8.9 8 1 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK55999.1 - 6.5e-28 95.6 69.4 3e-06 27.4 1.1 8.2 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK55999.1 - 1.1e-22 78.7 62.8 0.0033 18.2 2.4 8.2 8 0 0 8 8 8 6 C2H2-type zinc finger PyrI_C PF02748.15 PIK55999.1 - 9.7e-06 25.4 33.5 0.77 9.7 1.9 7.1 7 0 0 7 7 7 4 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK55999.1 - 1.1e-05 25.5 40.1 0.14 12.4 1.9 7.7 7 1 1 8 8 8 4 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 PIK55999.1 - 0.00089 20.0 26.4 0.063 14.0 0.6 4.2 3 1 1 4 4 4 2 zinc-ribbon family zf-C2H2_11 PF16622.5 PIK55999.1 - 0.0031 17.3 0.1 0.0031 17.3 0.1 6.0 6 0 0 6 6 6 2 zinc-finger C2H2-type C1_4 PF07975.12 PIK55999.1 - 0.0039 17.4 37.8 1.5 9.2 9.2 6.1 3 2 3 6 6 6 4 TFIIH C1-like domain zf-C2HE PF16278.5 PIK55999.1 - 0.0043 17.5 0.5 0.0043 17.5 0.5 6.5 3 2 4 7 7 7 2 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.11 PIK55999.1 - 0.031 14.1 6.3 9.4 6.1 0.1 4.8 3 1 2 5 5 5 0 GAGA factor zf-H2C2_5 PF13909.6 PIK55999.1 - 0.048 13.4 0.8 0.048 13.4 0.8 10.8 10 3 0 10 10 9 0 C2H2-type zinc-finger domain zinc_ribbon_5 PF13719.6 PIK55999.1 - 0.14 12.0 21.8 5 7.0 0.0 5.9 6 0 0 6 6 6 0 zinc-ribbon domain zf-BED PF02892.15 PIK55999.1 - 0.36 10.9 43.9 0.66 10.0 6.7 7.2 3 2 4 7 7 7 0 BED zinc finger zf-AN1 PF01428.16 PIK55999.1 - 0.54 10.5 39.8 1.1 9.5 2.1 7.1 5 2 2 7 7 7 0 AN1-like Zinc finger Siva PF05458.12 PIK55999.1 - 5.3 6.7 16.5 0.056 13.1 5.4 2.8 2 1 0 3 3 3 0 Cd27 binding protein (Siva) zf-met PF12874.7 PIK55999.1 - 8.3 7.0 33.5 0.9 10.0 0.2 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.7 PIK55999.1 - 9.9 6.2 35.9 1.5 8.9 2.9 6.1 5 1 1 6 6 6 0 Transposase zinc-ribbon domain CAP_GLY PF01302.25 PIK56001.1 - 0.0056 16.7 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 CAP-Gly domain LIAS_N PF16881.5 PIK56001.1 - 0.024 15.1 0.1 0.041 14.3 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family RVT_1 PF00078.27 PIK56003.1 - 1.2e-21 77.3 0.1 2.6e-21 76.2 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK56003.1 - 2e-12 47.5 0.0 3.8e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK56003.1 - 1.9e-11 44.4 0.0 3.4e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 PIK56003.1 - 0.00022 21.0 0.1 0.00041 20.1 0.1 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-C4 PF00105.18 PIK56003.1 - 0.013 15.9 0.6 0.013 15.9 0.6 2.8 3 1 0 3 3 2 0 Zinc finger, C4 type (two domains) Retrotrans_gag PF03732.17 PIK56003.1 - 0.022 15.0 0.0 0.048 13.9 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein DUF1758 PF05585.12 PIK56003.1 - 0.045 13.5 0.1 0.086 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Phage_tail_NK PF16532.5 PIK56003.1 - 0.15 11.7 0.7 4.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Sf6-type phage tail needle knob or tip of some Caudovirales Asp_protease PF09668.10 PIK56003.1 - 0.19 11.5 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK56003.1 - 0.94 9.7 9.4 0.091 12.9 1.6 3.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 PIK56003.1 - 5.1 6.9 12.9 0.14 11.9 4.1 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger RT_RNaseH PF17917.1 PIK56004.1 - 4.4e-31 107.3 0.1 5.6e-31 106.9 0.1 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK56004.1 - 4.6e-26 90.8 0.0 6.2e-26 90.4 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_ligase_A_M PF01068.21 PIK56004.1 - 0.0035 17.0 0.0 0.0057 16.3 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain Hormone_recep PF00104.30 PIK56005.1 - 4e-27 95.1 1.5 2.8e-26 92.4 0.0 2.6 3 0 0 3 3 3 1 Ligand-binding domain of nuclear hormone receptor rve PF00665.26 PIK56005.1 - 4.1e-26 91.5 0.0 1.1e-25 90.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-C4 PF00105.18 PIK56005.1 - 6.3e-19 68.2 8.2 6.3e-19 68.2 8.2 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) rve_3 PF13683.6 PIK56005.1 - 0.085 12.6 0.0 0.61 9.9 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain DUP PF00674.18 PIK56005.1 - 0.15 12.2 1.2 0.28 11.3 0.3 1.9 2 0 0 2 2 2 0 DUP family Homeobox_KN PF05920.11 PIK56006.1 - 1.5e-15 56.8 0.5 4.9e-15 55.1 0.2 2.2 3 0 0 3 3 3 1 Homeobox KN domain Homeodomain PF00046.29 PIK56006.1 - 1.1e-05 25.2 0.0 2.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Homeodomain WD40 PF00400.32 PIK56008.1 - 1.8e-25 88.7 27.7 2e-05 25.3 0.1 8.0 7 1 1 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56008.1 - 1.2e-13 51.1 3.3 0.036 14.4 0.0 5.9 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK56008.1 - 1.9e-07 31.2 0.0 0.055 13.3 0.0 3.1 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 PIK56008.1 - 0.0013 18.2 0.0 3 7.1 0.0 3.3 2 1 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 PIK56008.1 - 0.045 12.7 0.0 2.9 6.8 0.0 2.7 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_C552 PF02335.15 PIK56008.1 - 0.059 12.3 0.1 0.08 11.9 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c552 ICA69 PF04629.14 PIK56009.1 - 1.5e-18 68.1 8.0 1.6e-16 61.4 8.0 2.2 1 1 0 1 1 1 1 Islet cell autoantigen ICA69, C-terminal domain Arfaptin PF06456.13 PIK56011.1 - 3.6e-55 187.0 1.3 4.2e-55 186.8 1.3 1.0 1 0 0 1 1 1 1 Arfaptin-like domain UCH_N PF16674.5 PIK56012.1 - 3.9e-10 39.6 0.0 4.5e-10 39.4 0.0 1.0 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 Nucleoporin_N PF08801.11 PIK56013.1 - 1.5e-80 271.1 0.1 6.5e-79 265.7 0.0 2.1 1 1 1 2 2 2 2 Nup133 N terminal like Nucleoporin_C PF03177.14 PIK56013.1 - 3.3e-25 88.9 2.4 4.7e-25 88.4 2.4 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nup160 PF11715.8 PIK56013.1 - 0.0039 15.9 0.0 0.0063 15.2 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 RPN1_RPN2_N PF17781.1 PIK56013.1 - 0.014 14.8 0.1 0.03 13.7 0.1 1.5 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain Efg1 PF10153.9 PIK56013.1 - 0.024 15.0 0.1 0.073 13.4 0.1 1.8 1 0 0 1 1 1 0 rRNA-processing protein Efg1 D5_N PF08706.11 PIK56013.1 - 0.092 13.0 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 D5 N terminal like Guanylate_cyc PF00211.20 PIK56015.1 - 6.3e-63 211.7 0.1 1.1e-62 211.0 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase PF00069.25 PIK56015.1 - 5.6e-39 134.1 0.0 8.9e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56015.1 - 1.2e-37 129.6 0.0 2.1e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HNOBA PF07701.14 PIK56015.1 - 1.3e-05 24.7 0.6 2e-05 24.2 0.6 1.2 1 0 0 1 1 1 1 Heme NO binding associated Kinase-like PF14531.6 PIK56015.1 - 0.0025 17.2 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RhoGAP PF00620.27 PIK56016.1 - 1.3e-45 154.9 0.5 5.4e-45 152.9 0.5 2.1 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 PIK56016.1 - 6.6e-07 29.1 3.9 1.6e-06 27.9 3.9 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.23 PIK56016.1 - 5.1e-05 23.5 5.9 0.001 19.3 5.9 2.9 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain zinc-ribbon_6 PF10005.9 PIK56016.1 - 1.6 9.4 7.9 0.77 10.5 2.8 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DOMON PF03351.17 PIK56017.1 - 6e-10 39.4 0.1 1e-09 38.6 0.1 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 PIK56017.1 - 1.1e-06 28.8 7.2 2.2e-06 27.8 6.1 2.0 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 PQ-loop PF04193.14 PIK56018.1 - 3.7e-36 122.7 20.3 6.1e-19 67.5 4.0 3.1 3 0 0 3 3 3 2 PQ loop repeat DUF4236 PF14020.6 PIK56018.1 - 0.029 14.9 0.1 1.6 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4236) Oxysterol_BP PF01237.18 PIK56019.1 - 4.3e-133 443.7 0.2 5.2e-133 443.5 0.2 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Glyco_transf_10 PF00852.19 PIK56020.1 - 7.2e-53 178.9 0.2 1e-52 178.4 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK56020.1 - 1.5e-14 54.4 0.0 3.8e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Casc1 PF12366.8 PIK56021.1 - 0.096 12.2 1.4 0.13 11.7 1.4 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Phospholip_B PF04916.13 PIK56022.1 - 6.5e-169 562.9 2.3 7.4e-169 562.7 2.3 1.0 1 0 0 1 1 1 1 Phospholipase B CTP_transf_like PF01467.26 PIK56023.1 - 3.8e-50 169.8 0.1 1.3e-28 100.0 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 PIK56023.1 - 0.00052 19.9 5.5 0.91 9.4 0.1 4.3 3 2 0 3 3 3 2 FAD synthetase CENP-X PF09415.10 PIK56024.1 - 6.4e-25 87.3 2.3 7e-25 87.1 2.3 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 PIK56024.1 - 0.0004 20.6 1.0 0.00044 20.5 1.0 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 7tm_1 PF00001.21 PIK56025.1 - 3.2e-48 164.3 14.2 4e-48 164.0 14.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK56025.1 - 0.12 11.6 18.9 1.6 8.0 18.9 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw CYYR1 PF10873.8 PIK56025.1 - 0.15 12.5 0.7 0.38 11.2 0.7 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 DHHC PF01529.20 PIK56025.1 - 4.6 7.4 15.2 0.44 10.7 3.5 3.1 3 0 0 3 3 3 0 DHHC palmitoyltransferase Podoplanin PF05808.11 PIK56025.1 - 7 6.7 7.1 15 5.7 7.1 1.5 1 0 0 1 1 1 0 Podoplanin RecX PF02631.16 PIK56026.1 - 0.072 13.5 0.3 0.14 12.7 0.3 1.4 1 0 0 1 1 1 0 RecX family CBP_BcsO PF17037.5 PIK56026.1 - 0.16 12.1 5.6 0.29 11.3 5.6 1.4 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsO GBP_C PF02841.14 PIK56027.1 - 0.0013 18.2 0.2 0.0021 17.5 0.2 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain 7tm_1 PF00001.21 PIK56028.1 - 1.5e-23 83.5 2.7 2.1e-23 83.0 2.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56028.1 - 0.00042 19.8 4.4 0.00057 19.3 4.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Myc_target_1 PF15179.6 PIK56028.1 - 0.12 12.3 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Myc target protein 1 Peptidase_C97 PF05903.14 PIK56029.1 - 1.1e-40 138.9 0.0 1.7e-40 138.3 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 PIK56029.1 - 7.4e-18 64.8 0.3 1.1e-17 64.1 0.3 1.2 1 0 0 1 1 1 1 PUL domain Ras PF00071.22 PIK56030.1 - 3.7e-29 101.4 0.0 4.5e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK56030.1 - 7.3e-18 64.9 0.1 1e-17 64.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK56030.1 - 6.8e-07 28.9 0.0 8.1e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK56030.1 - 0.0092 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FAM220 PF15487.6 PIK56031.1 - 1.7e-53 182.1 0.2 8.6e-53 179.7 0.0 1.8 2 0 0 2 2 2 1 FAM220 family Ank_2 PF12796.7 PIK56031.1 - 1.6e-14 54.2 1.4 7.4e-12 45.7 0.6 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK56031.1 - 1.8e-14 53.9 0.4 4.5e-08 33.5 0.1 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK56031.1 - 1.3e-11 44.4 6.1 1.5e-06 28.3 0.4 4.3 3 1 1 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 PIK56031.1 - 2.8e-11 42.6 1.4 0.00043 20.5 0.1 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK56031.1 - 8.2e-08 32.4 3.7 2e-05 24.7 1.0 3.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) ABC_membrane PF00664.23 PIK56032.1 - 6.9e-38 130.9 15.2 6.9e-38 130.9 15.2 2.3 3 0 0 3 3 3 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK56032.1 - 1.2e-22 80.9 0.6 3.2e-21 76.3 0.1 2.4 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 PIK56032.1 - 0.00051 20.0 1.3 0.014 15.3 1.3 2.4 1 1 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 PIK56032.1 - 0.003 17.1 0.1 0.052 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK56032.1 - 0.0037 17.7 0.0 0.0075 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 PIK56032.1 - 0.0069 15.8 0.2 1.2 8.5 0.2 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 PIK56032.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK56032.1 - 0.015 15.3 1.8 0.019 15.1 0.5 1.8 2 0 0 2 2 2 0 Dynamin family BSP_II PF05432.11 PIK56032.1 - 0.032 14.0 0.5 0.058 13.1 0.5 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Zeta_toxin PF06414.12 PIK56032.1 - 0.039 13.2 0.2 0.11 11.7 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 PIK56032.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK56032.1 - 0.17 11.4 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 PIK56033.1 - 1.1e-31 110.2 0.0 2.2e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK56033.1 - 6.3e-15 55.6 1.6 8.3e-15 55.2 1.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK56033.1 - 5.9e-05 22.6 0.2 0.0024 17.3 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 PIK56033.1 - 0.0077 16.0 0.3 0.11 12.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 PIK56033.1 - 0.037 14.1 0.1 0.12 12.5 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 PIK56033.1 - 0.24 11.1 0.6 4.7 6.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain Ribosomal_L12 PF00542.19 PIK56034.1 - 6.7e-20 71.2 5.8 1.4e-19 70.2 3.8 2.2 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 PIK56034.1 - 2.9e-13 49.3 0.1 2.9e-13 49.3 0.1 3.2 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain CSTF2_hinge PF14327.6 PIK56034.1 - 0.0067 16.8 2.1 0.23 11.9 0.2 2.2 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 MRP-S27 PF10037.9 PIK56034.1 - 0.26 10.1 3.5 0.69 8.7 3.5 1.6 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF2367 PF10164.9 PIK56035.1 - 1.6e-26 92.8 6.5 1.9e-26 92.5 6.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) zf-RRN7 PF11781.8 PIK56035.1 - 0.058 13.1 0.9 3.1 7.6 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TerY_C PF15616.6 PIK56035.1 - 2.7 8.1 6.8 7.7 6.6 6.8 1.6 1 1 0 1 1 1 0 TerY-C metal binding domain DUF2367 PF10164.9 PIK56036.1 - 1.5e-25 89.7 10.5 1.8e-25 89.4 10.5 1.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) Sema PF01403.19 PIK56037.1 - 5.6e-14 51.8 0.0 8.9e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 Sema domain Thioredoxin PF00085.20 PIK56038.1 - 7.4e-27 93.3 0.0 8.5e-27 93.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 PIK56038.1 - 2.5e-07 30.9 0.0 3.9e-05 23.9 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 PIK56038.1 - 6.8e-06 25.9 0.0 0.00012 21.9 0.0 2.0 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.21 PIK56038.1 - 1.2e-05 25.3 0.0 2.9e-05 24.0 0.0 1.5 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 PIK56038.1 - 2.2e-05 24.9 0.0 7.2e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 PIK56038.1 - 6.6e-05 22.8 0.0 7.5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 PIK56038.1 - 0.00029 21.0 0.0 0.00055 20.1 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 PIK56038.1 - 0.00033 20.4 0.0 0.0004 20.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 PIK56038.1 - 0.0081 15.5 0.0 0.011 15.1 0.0 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 PIK56038.1 - 0.016 15.2 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain DUF836 PF05768.14 PIK56038.1 - 0.097 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin PF00085.20 PIK56039.1 - 3.4e-10 39.8 0.0 4.1e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF836 PF05768.14 PIK56039.1 - 0.0088 16.4 0.0 0.01 16.2 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) SET PF00856.28 PIK56040.1 - 5.4e-07 30.1 0.5 8.9e-06 26.2 0.0 3.0 2 1 0 2 2 2 1 SET domain DUF1409 PF07197.12 PIK56040.1 - 0.0013 18.6 1.2 6.4 6.8 0.0 3.7 1 1 2 3 3 3 2 Protein of unknown function (DUF1409) TMF_DNA_bd PF12329.8 PIK56040.1 - 2.8 8.0 9.3 3.7 7.6 1.8 2.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Glyco_transf_10 PF00852.19 PIK56041.1 - 2.1e-42 144.8 0.2 3.2e-42 144.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK56041.1 - 1.8e-18 67.0 0.1 4.6e-18 65.7 0.1 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal LRR19-TM PF15176.6 PIK56041.1 - 0.052 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain zf_CopZ PF18423.1 PIK56041.1 - 0.16 11.9 0.6 1.8 8.6 0.0 2.6 2 1 1 3 3 3 0 Zinc binding domain Glyco_transf_10 PF00852.19 PIK56042.1 - 3.2e-49 167.0 4.7 4.7e-49 166.5 4.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK56042.1 - 3e-14 53.4 0.0 6.7e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Zincin_2 PF10103.9 PIK56042.1 - 0.026 13.8 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Zincin-like metallopeptidase DEAD PF00270.29 PIK56043.1 - 7.6e-25 87.7 0.0 1.2e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Thioredoxin PF00085.20 PIK56043.1 - 0.018 15.0 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin ResIII PF04851.15 PIK56043.1 - 0.033 14.2 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK56044.1 - 5.5e-23 81.4 0.0 1.1e-22 80.4 0.0 1.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AMP-binding PF00501.28 PIK56045.1 - 1.6e-75 254.3 0.6 4.2e-57 193.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding PF00501.28 PIK56046.1 - 2.8e-07 29.5 0.0 3.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DMAP_binding PF06464.11 PIK56046.1 - 6e-06 27.0 1.5 1.1e-05 26.2 1.5 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain VapB_antitoxin PF09957.9 PIK56046.1 - 0.21 11.5 0.0 3.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB NUDIX PF00293.28 PIK56047.1 - 6.2e-18 65.1 0.0 1e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DCP2 PF05026.13 PIK56047.1 - 0.15 12.4 0.0 0.56 10.6 0.0 2.0 2 0 0 2 2 2 0 Dcp2, box A domain Ccdc124 PF06244.12 PIK56049.1 - 4.2e-40 137.3 8.0 4.2e-40 137.3 8.0 2.3 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 PIK56049.1 - 0.0009 19.6 0.2 0.0009 19.6 0.2 3.1 2 1 1 3 3 3 1 HMG (high mobility group) box Oxysterol_BP PF01237.18 PIK56049.1 - 4.2 6.1 13.9 3.1 6.5 12.7 1.4 1 1 0 1 1 1 0 Oxysterol-binding protein Zip PF02535.22 PIK56050.1 - 1.2e-21 77.4 5.4 1.3e-21 77.2 5.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Beta-lactamase PF00144.24 PIK56050.1 - 0.24 10.6 0.0 0.29 10.3 0.0 1.0 1 0 0 1 1 1 0 Beta-lactamase Rav1p_C PF12234.8 PIK56051.1 - 1.5e-85 287.9 1.3 2.9e-70 237.4 0.4 3.8 3 1 0 3 3 3 3 RAVE protein 1 C terminal WD40 PF00400.32 PIK56051.1 - 1.7e-13 50.8 13.8 0.00022 22.0 0.0 8.4 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56051.1 - 0.00012 22.3 0.0 0.0013 19.0 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PTE PF02126.18 PIK56051.1 - 0.016 14.6 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotriesterase family DUF5543 PF17697.1 PIK56051.1 - 0.13 12.5 0.1 11 6.3 0.0 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5543) FWWh PF14922.6 PIK56052.1 - 2.3e-23 82.7 4.9 2.3e-21 76.3 1.9 2.7 2 1 1 3 3 3 2 Protein of unknown function SRP14 PF02290.15 PIK56052.1 - 0.019 15.3 0.1 0.038 14.3 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle 14kD protein TetR_C_15 PF17918.1 PIK56052.1 - 0.058 14.2 0.6 0.081 13.7 0.1 1.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain BUD22 PF09073.10 PIK56053.1 - 1.6e-06 27.7 58.7 3.7e-05 23.3 8.3 2.9 1 1 0 2 2 2 2 BUD22 NOA36 PF06524.12 PIK56053.1 - 0.00026 20.4 10.5 0.00026 20.4 10.5 1.9 2 0 0 2 2 2 1 NOA36 protein PI3K_1B_p101 PF10486.9 PIK56053.1 - 0.84 7.3 11.7 1.3 6.7 11.7 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pkinase PF00069.25 PIK56054.1 - 4.7e-12 45.8 0.0 5.6e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain PB1 PF00564.24 PIK56054.1 - 1.2e-07 31.6 0.0 3.3e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 PB1 domain Pkinase_Tyr PF07714.17 PIK56054.1 - 1.2e-05 24.8 0.0 0.00013 21.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase A_deaminase PF00962.22 PIK56055.1 - 1.3e-25 90.5 0.0 1.6e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF768 PF05589.11 PIK56055.1 - 0.14 12.2 0.1 11 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF768) RT_RNaseH PF17917.1 PIK56056.1 - 2.7e-28 98.3 0.0 3.6e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK56056.1 - 1.8e-22 79.3 0.0 3.1e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pox_T4_C PF04490.12 PIK56056.1 - 0.052 13.7 0.0 0.069 13.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus DUF2854 PF11016.8 PIK56056.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) Phytoreo_P8 PF07124.11 PIK56056.1 - 0.13 11.2 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus outer capsid protein P8 RVT_1 PF00078.27 PIK56057.1 - 2.7e-18 66.3 0.0 3.5e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) L51_S25_CI-B8 PF05047.16 PIK56058.1 - 5.6e-10 39.0 0.1 1.2e-09 37.9 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Septin PF00735.18 PIK56060.1 - 4.2e-08 32.8 0.2 4.1e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 PIK56060.1 - 5.1e-07 29.8 0.1 1.4e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 PIK56060.1 - 2.5e-05 23.7 0.8 2.5e-05 23.7 0.8 2.5 2 1 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 PIK56060.1 - 0.0016 18.4 0.4 0.0079 16.1 0.0 2.4 3 0 0 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 PIK56060.1 - 0.021 15.2 0.1 0.069 13.5 0.1 1.9 1 0 0 1 1 1 0 RNA helicase FeoB_N PF02421.18 PIK56060.1 - 0.023 14.2 0.5 7.6 6.0 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK56060.1 - 0.032 14.3 3.8 0.1 12.7 0.0 3.0 4 0 0 4 4 4 0 Dynamin family PduV-EutP PF10662.9 PIK56060.1 - 0.085 12.6 0.2 4 7.2 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 PIK56060.1 - 0.086 13.1 0.8 0.5 10.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 PIK56060.1 - 0.11 12.9 0.0 0.39 11.1 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 PIK56060.1 - 0.14 12.6 1.3 0.34 11.4 0.0 2.3 3 0 0 3 3 3 0 ABC transporter SMC_N PF02463.19 PIK56060.1 - 0.62 9.4 5.9 1.5 8.2 0.0 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain C1_1 PF00130.22 PIK56060.1 - 0.97 9.4 8.8 0.04 13.8 2.1 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CCHC PF00098.23 PIK56061.1 - 0.033 14.3 2.8 0.033 14.3 2.8 3.3 3 1 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK56061.1 - 0.076 12.8 7.3 0.84 9.4 4.0 2.9 2 1 1 3 3 3 0 Zinc knuckle IBR PF01485.21 PIK56061.1 - 2.4 8.5 9.3 5.1 7.4 9.3 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Septin PF00735.18 PIK56062.1 - 2.5e-07 30.3 0.0 4.6e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Septin AIG1 PF04548.16 PIK56062.1 - 4e-07 29.6 0.8 3.8e-06 26.4 0.8 2.1 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK56062.1 - 9e-07 29.0 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK56062.1 - 0.00014 21.8 0.0 0.00034 20.6 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase PduV-EutP PF10662.9 PIK56062.1 - 0.0013 18.4 0.1 0.38 10.5 0.1 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 PIK56062.1 - 0.0031 17.6 0.1 0.82 9.7 0.0 2.6 1 1 1 2 2 2 1 Dynamin family AAA_7 PF12775.7 PIK56062.1 - 0.0049 16.4 0.1 0.011 15.2 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 PIK56062.1 - 0.0049 16.0 0.2 0.0072 15.4 0.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 PIK56062.1 - 0.0055 17.2 0.1 0.0077 16.8 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 PIK56062.1 - 0.0096 16.2 0.2 0.025 14.8 0.2 1.7 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 PIK56062.1 - 0.011 15.3 0.1 5 6.6 0.1 2.5 3 0 0 3 3 2 0 Ferrous iron transport protein B NTPase_P4 PF11602.8 PIK56062.1 - 0.015 14.6 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 ResIII PF04851.15 PIK56062.1 - 0.028 14.4 1.1 0.042 13.9 0.1 1.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 PIK56062.1 - 0.03 14.8 1.0 0.074 13.5 1.0 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 PIK56062.1 - 0.033 14.6 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase GTP_EFTU PF00009.27 PIK56062.1 - 0.041 13.4 0.0 0.096 12.2 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 PIK56062.1 - 0.06 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 PIK56062.1 - 0.06 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 PIK56062.1 - 0.063 13.0 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CLP1_P PF16575.5 PIK56062.1 - 0.068 13.0 0.2 18 5.0 0.0 2.9 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 PIK56062.1 - 0.075 12.7 0.4 0.37 10.4 0.3 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain TrwB_AAD_bind PF10412.9 PIK56062.1 - 0.085 11.8 0.2 0.14 11.0 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 PIK56062.1 - 0.087 12.8 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 PIK56062.1 - 0.11 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.19 PIK56062.1 - 0.18 11.4 0.1 0.77 9.3 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 PIK56062.1 - 0.21 11.3 0.1 0.67 9.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain MRP-S33 PF08293.11 PIK56063.1 - 6.8e-26 90.3 2.7 8.5e-26 90.0 2.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 SRCR PF00530.18 PIK56064.1 - 6.4e-16 58.7 3.2 1.2e-15 57.8 3.2 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain fn3 PF00041.21 PIK56064.1 - 1.4e-14 54.2 1.3 4.6e-07 30.1 0.2 3.7 3 1 0 3 3 3 3 Fibronectin type III domain Trypsin PF00089.26 PIK56064.1 - 1.4e-12 47.9 0.1 3.7e-12 46.5 0.0 1.7 2 0 0 2 2 2 1 Trypsin SRCR_2 PF15494.6 PIK56064.1 - 2.4e-07 31.2 3.1 5.3e-07 30.1 3.1 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.11 PIK56064.1 - 5e-05 23.7 0.0 9.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) NUDIX PF00293.28 PIK56065.1 - 2.3e-10 40.6 0.0 2.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain EspB PF05802.11 PIK56066.1 - 0.011 15.7 0.3 0.011 15.7 0.3 2.2 2 1 0 2 2 2 0 Enterobacterial EspB protein DUF2730 PF10805.8 PIK56066.1 - 0.019 15.0 3.9 3.5 7.8 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2730) T2SSF PF00482.23 PIK56066.1 - 0.02 14.9 0.3 7.8 6.5 0.0 2.7 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F KELK PF15796.5 PIK56066.1 - 0.028 14.9 1.6 0.028 14.9 1.6 3.2 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase SesA PF17107.5 PIK56066.1 - 0.039 14.1 4.2 1.4 9.2 0.0 2.9 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF5344 PF17279.2 PIK56066.1 - 0.11 13.1 0.2 0.11 13.1 0.2 2.8 3 1 1 4 4 4 0 Family of unknown function (DUF5344) DUF2207 PF09972.9 PIK56066.1 - 0.12 11.1 0.7 0.71 8.6 0.7 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) FlgN PF05130.12 PIK56066.1 - 0.31 11.5 7.4 0.54 10.8 2.3 3.0 2 2 0 2 2 2 0 FlgN protein DUF16 PF01519.16 PIK56066.1 - 0.39 11.2 14.5 9.6 6.8 0.5 3.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Fez1 PF06818.15 PIK56066.1 - 1.1 9.7 14.7 3.4 8.1 14.6 1.9 1 1 0 1 1 1 0 Fez1 SKA2 PF16740.5 PIK56066.1 - 1.1 9.0 8.8 4.1 7.2 1.0 3.4 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF2115 PF09888.9 PIK56066.1 - 1.5 9.3 5.4 13 6.2 2.7 2.8 2 2 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) DUF4776 PF16003.5 PIK56066.1 - 4.3 6.2 7.5 1.2 8.0 4.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) TMPIT PF07851.13 PIK56066.1 - 7.8 5.6 12.5 13 5.0 0.2 2.9 3 0 0 3 3 3 0 TMPIT-like protein Aminotran_1_2 PF00155.21 PIK56067.1 - 1.3e-67 228.5 0.0 2.1e-67 227.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.10 PIK56067.1 - 4e-12 46.6 2.0 4.6e-10 40.0 1.5 2.7 1 1 0 1 1 1 1 5-aminolevulinate synthase presequence Aminotran_5 PF00266.19 PIK56067.1 - 3e-07 29.7 0.1 5.5e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 PIK56067.1 - 9.4e-07 27.7 0.0 1.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme RNA_polI_A34 PF08208.11 PIK56068.1 - 3.4e-21 76.3 30.3 1.6e-19 70.9 30.3 2.1 1 1 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 SIT PF15330.6 PIK56068.1 - 0.16 12.4 6.5 0.33 11.4 6.5 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Fn_bind PF02986.14 PIK56068.1 - 1.3 8.8 6.1 21 5.0 0.1 2.7 2 0 0 2 2 2 0 Fibronectin binding repeat DnaJ PF00226.31 PIK56069.1 - 5.7e-29 100.0 1.3 5.7e-29 100.0 1.3 1.7 2 0 0 2 2 2 1 DnaJ domain LON_substr_bdg PF02190.16 PIK56070.1 - 3.1e-11 43.5 0.0 3.7e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain I-set PF07679.16 PIK56073.1 - 1.1e-07 31.9 0.1 1.3e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK56073.1 - 0.0026 18.1 0.0 0.0037 17.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Receptor_2B4 PF11465.8 PIK56073.1 - 0.0038 17.4 0.0 0.0052 17.0 0.0 1.3 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 Ig_3 PF13927.6 PIK56073.1 - 0.004 17.7 0.0 0.0058 17.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK56073.1 - 0.024 14.8 0.3 0.038 14.2 0.3 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK56073.1 - 0.031 14.4 0.3 0.04 14.1 0.3 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain I-set PF07679.16 PIK56074.1 - 1.1e-06 28.6 0.0 1.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Receptor_2B4 PF11465.8 PIK56074.1 - 0.0046 17.1 0.1 0.0077 16.4 0.1 1.3 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 V-set PF07686.17 PIK56074.1 - 0.0077 16.4 0.1 0.01 16.0 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK56074.1 - 0.024 15.2 0.1 0.063 13.9 0.0 1.8 1 1 1 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 PIK56074.1 - 0.086 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 PIK56074.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain RT_RNaseH_2 PF17919.1 PIK56075.1 - 1e-30 105.7 0.1 2.2e-30 104.6 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56075.1 - 2.7e-25 88.7 0.0 5.6e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56075.1 - 5.4e-19 68.6 0.1 1.2e-18 67.5 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK56075.1 - 6.3e-17 61.4 0.7 1.9e-16 59.9 0.7 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56075.1 - 5.6e-16 58.8 0.0 1.3e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK56075.1 - 3.2e-06 27.3 0.2 9.4e-06 25.7 0.2 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK56075.1 - 0.0057 16.4 0.1 0.066 13.0 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK56075.1 - 0.0078 16.3 1.5 0.0078 16.3 1.5 2.9 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 PIK56075.1 - 0.027 14.8 0.7 0.027 14.8 0.7 2.9 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G DUF4537 PF15057.6 PIK56075.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) zf-CCCH_7 PF18586.1 PIK56075.1 - 0.13 12.6 3.1 0.16 12.3 0.8 2.4 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 zf-CCHC_5 PF14787.6 PIK56075.1 - 4.9 6.9 13.4 0.28 10.9 3.8 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger CATSPERD PF15020.6 PIK56076.1 - 1.6e-25 89.5 1.3 1.6e-25 89.5 1.3 1.7 1 1 1 2 2 2 1 Cation channel sperm-associated protein subunit delta UCH PF00443.29 PIK56077.1 - 1.3e-45 155.9 0.1 1.3e-45 155.9 0.1 3.5 3 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK56077.1 - 1.9e-26 93.4 1.9 1.7e-20 73.9 0.1 2.9 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase MMS19_N PF14500.6 PIK56077.1 - 0.021 14.4 2.1 1.8 8.1 0.0 3.9 3 1 1 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF2407 PF10302.9 PIK56077.1 - 0.062 13.9 0.0 0.22 12.1 0.0 2.0 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain zf-H2C2_2 PF13465.6 PIK56077.1 - 0.8 10.2 3.8 5.2 7.7 0.4 3.0 2 0 0 2 2 2 0 Zinc-finger double domain FliS PF02561.14 PIK56077.1 - 0.9 9.8 3.7 6.4 7.1 0.1 3.0 2 0 0 2 2 2 0 Flagellar protein FliS zf-H2C2_5 PF13909.6 PIK56078.1 - 4.1e-14 52.0 30.3 7.1e-10 38.5 4.1 4.6 4 0 0 4 4 4 4 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK56078.1 - 4.1e-11 42.7 34.3 0.00085 19.7 1.7 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK56078.1 - 1.4e-06 28.6 32.1 0.0064 17.2 1.1 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK56078.1 - 8.8e-06 25.9 28.7 0.00064 20.0 3.4 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-met PF12874.7 PIK56078.1 - 0.029 14.8 0.1 0.029 14.8 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK56078.1 - 0.13 12.6 13.4 0.31 11.4 0.2 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK56078.1 - 0.63 10.1 17.2 3.2 7.8 1.7 3.5 2 1 1 3 3 3 0 BED zinc finger Endonuclease_7 PF02945.15 PIK56078.1 - 0.76 9.7 11.8 0.029 14.3 4.3 2.3 1 1 1 2 2 2 0 Recombination endonuclease VII Pkinase_Tyr PF07714.17 PIK56079.1 - 1.6e-71 240.6 0.0 9e-71 238.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56079.1 - 6.2e-34 117.6 0.0 2.3e-32 112.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Haspin_kinase PF12330.8 PIK56079.1 - 0.00014 20.9 0.0 0.00026 20.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Ank_2 PF12796.7 PIK56080.1 - 1.8e-19 70.1 0.0 4.1e-09 36.9 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SH2 PF00017.24 PIK56080.1 - 5.4e-19 68.1 0.0 9.3e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Ank_4 PF13637.6 PIK56080.1 - 5.8e-18 65.0 0.2 1e-06 29.2 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK56080.1 - 2.3e-17 62.5 1.0 0.00028 21.2 0.1 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK56080.1 - 8e-16 57.9 0.1 6.5e-05 23.1 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK56080.1 - 1.5e-13 49.6 0.1 0.00061 20.0 0.1 5.5 6 0 0 6 6 6 2 Ankyrin repeat Zwilch PF09817.9 PIK56080.1 - 0.2 10.0 0.0 0.26 9.7 0.0 1.1 1 0 0 1 1 1 0 RZZ complex, subunit zwilch Exo_endo_phos PF03372.23 PIK56082.1 - 1.1e-05 25.0 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4528 PF15031.6 PIK56082.1 - 0.062 13.4 0.0 0.27 11.3 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) SAM_1 PF00536.30 PIK56083.1 - 6.7e-12 45.7 0.0 9.1e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK56083.1 - 3.8e-10 39.7 0.0 5.5e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) BLM_N PF16202.5 PIK56083.1 - 0.65 9.1 3.5 0.21 10.7 1.1 1.4 2 0 0 2 2 2 0 N-terminal region of Bloom syndrome protein Med11 PF10280.9 PIK56084.1 - 5.6e-16 59.3 1.8 6.9e-16 58.9 1.8 1.1 1 0 0 1 1 1 1 Mediator complex protein DHR10 PF18595.1 PIK56084.1 - 0.0026 17.8 2.3 0.18 11.9 0.2 2.3 1 1 1 2 2 2 2 Designed helical repeat protein 10 domain YlqD PF11068.8 PIK56084.1 - 0.0091 16.4 1.5 0.0092 16.4 0.6 1.4 1 1 0 1 1 1 1 YlqD protein SLAM PF06214.11 PIK56084.1 - 0.011 15.8 0.3 0.012 15.6 0.3 1.2 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein Dak2 PF02734.17 PIK56084.1 - 0.019 14.9 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 DAK2 domain PMC2NT PF08066.12 PIK56084.1 - 0.052 14.3 0.3 0.07 13.8 0.3 1.4 1 1 0 1 1 1 0 PMC2NT (NUC016) domain NOG1_N PF17835.1 PIK56084.1 - 0.065 13.2 0.9 0.22 11.5 0.2 1.8 2 0 0 2 2 2 0 NOG1 N-terminal helical domain DASH_Duo1 PF08651.10 PIK56084.1 - 0.19 11.5 2.0 0.48 10.2 0.5 2.1 1 1 1 2 2 2 0 DASH complex subunit Duo1 DUF148 PF02520.17 PIK56084.1 - 0.45 10.6 3.9 5.9 7.1 0.1 2.8 1 1 2 3 3 3 0 Domain of unknown function DUF148 SAP130_C PF16014.5 PIK56086.1 - 6.3e-40 137.5 7.5 7.5e-40 137.3 7.5 1.1 1 0 0 1 1 1 1 Histone deacetylase complex subunit SAP130 C-terminus Pkinase PF00069.25 PIK56087.1 - 6.7e-27 94.5 0.0 8.1e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56087.1 - 1.6e-18 66.9 0.0 1.8e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK56087.1 - 3.7e-06 26.0 0.0 4.2e-06 25.8 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK56087.1 - 0.0018 17.7 0.1 0.0021 17.4 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 PIK56087.1 - 0.0034 17.0 0.0 0.004 16.8 0.0 1.1 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 PIK56087.1 - 0.0089 15.6 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 PIK56087.1 - 0.018 14.4 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 PIK56087.1 - 0.022 14.7 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 PIK56087.1 - 0.087 12.3 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 PIK56087.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 PIK56088.1 - 0.001 18.5 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 PIK56089.1 - 6.1e-39 134.3 0.0 5.7e-38 131.1 0.0 1.9 1 1 1 2 2 2 2 CNH domain Rdx PF10262.9 PIK56090.1 - 1.7e-08 34.5 0.0 2.1e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Rdx family PP2C PF00481.21 PIK56091.1 - 3.5e-54 184.2 0.0 4.6e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK56091.1 - 8.8e-08 32.0 0.1 1.5e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 PIK56091.1 - 0.0063 16.5 0.0 0.97 9.3 0.0 2.6 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) WD40 PF00400.32 PIK56093.1 - 1.3e-16 60.6 14.5 0.0078 17.0 0.2 7.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56093.1 - 2e-14 53.7 1.3 0.029 14.7 0.0 6.9 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK56093.1 - 5e-05 23.3 0.1 0.0052 16.7 0.0 3.8 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK56093.1 - 0.0001 21.4 0.0 0.12 11.3 0.0 2.8 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 PIK56093.1 - 0.039 13.9 2.8 23 5.0 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Ig_2 PF13895.6 PIK56094.1 - 0.0001 22.6 0.1 0.00029 21.1 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 PIK56094.1 - 0.00022 21.7 0.3 0.0009 19.8 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain DUF5527 PF17665.1 PIK56094.1 - 0.021 14.3 0.5 0.037 13.6 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DUF1180 PF06679.12 PIK56094.1 - 0.031 14.7 0.2 0.055 13.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Fig1 PF12351.8 PIK56094.1 - 0.036 14.0 0.3 0.07 13.1 0.3 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 TMEM154 PF15102.6 PIK56094.1 - 0.036 14.0 1.8 0.06 13.2 1.8 1.3 1 0 0 1 1 1 0 TMEM154 protein family Protocadherin PF08374.11 PIK56094.1 - 0.046 13.7 0.4 0.066 13.2 0.4 1.2 1 0 0 1 1 1 0 Protocadherin ig PF00047.25 PIK56094.1 - 0.054 13.7 0.8 0.41 10.9 0.8 2.4 1 1 0 1 1 1 0 Immunoglobulin domain DUF4711 PF15829.5 PIK56094.1 - 0.1 12.5 2.5 0.24 11.4 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Ig_2 PF13895.6 PIK56095.1 - 1.5e-05 25.2 0.4 8.4e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK56095.1 - 0.00012 22.5 0.3 0.00082 19.9 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain SID-1_RNA_chan PF13965.6 PIK56095.1 - 0.0057 15.1 2.0 0.0087 14.5 2.0 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Peptidase_M56 PF05569.11 PIK56095.1 - 0.047 12.9 0.6 0.068 12.4 0.6 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 HPIH PF13323.6 PIK56095.1 - 0.057 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain with HPIH motif Ly49 PF08391.10 PIK56095.1 - 0.058 13.8 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region TMEM154 PF15102.6 PIK56095.1 - 0.065 13.1 3.7 0.11 12.4 3.7 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF1180 PF06679.12 PIK56095.1 - 0.065 13.7 0.4 0.11 12.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4834 PF16118.5 PIK56095.1 - 0.11 13.5 1.3 0.34 11.9 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 PIK56095.1 - 0.12 13.3 0.0 0.3 12.0 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Trp_oprn_chp PF09534.10 PIK56095.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ig PF00047.25 PIK56095.1 - 0.42 10.8 5.2 0.23 11.6 0.7 2.8 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK56096.1 - 8.3e-06 26.1 0.5 3.9e-05 23.9 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK56096.1 - 0.0008 20.0 1.9 0.0016 19.0 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain DAG1 PF05454.11 PIK56096.1 - 0.029 13.7 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) LRR19-TM PF15176.6 PIK56096.1 - 0.041 13.9 0.2 0.22 11.5 0.0 2.3 2 1 1 3 3 3 0 Leucine-rich repeat family 19 TM domain DUF2232 PF09991.9 PIK56096.1 - 0.086 12.0 0.2 0.13 11.4 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) ig PF00047.25 PIK56096.1 - 0.88 9.8 5.3 0.74 10.0 0.7 3.0 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK56097.1 - 5e-05 23.6 0.4 0.00016 21.9 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.6 PIK56097.1 - 0.00013 21.9 2.4 0.00016 21.6 1.6 1.5 1 1 0 1 1 1 1 TMEM154 protein family Protocadherin PF08374.11 PIK56097.1 - 0.0014 18.7 0.6 0.0022 18.0 0.6 1.2 1 0 0 1 1 1 1 Protocadherin Ig_3 PF13927.6 PIK56097.1 - 0.0014 19.2 1.1 0.008 16.8 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain OSTbeta PF15048.6 PIK56097.1 - 0.0017 18.5 0.1 0.0031 17.6 0.1 1.4 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein DUF4834 PF16118.5 PIK56097.1 - 0.003 18.5 0.1 0.016 16.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) TMEM51 PF15345.6 PIK56097.1 - 0.004 17.0 0.2 0.0061 16.4 0.2 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 Glycophorin_A PF01102.18 PIK56097.1 - 0.0043 17.3 1.1 0.0088 16.3 0.8 1.7 1 1 0 1 1 1 1 Glycophorin A FAM176 PF14851.6 PIK56097.1 - 0.0044 16.7 0.3 0.0087 15.7 0.3 1.5 1 0 0 1 1 1 1 FAM176 family Shisa PF13908.6 PIK56097.1 - 0.0064 16.8 1.2 0.011 15.9 1.2 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK56097.1 - 0.01 16.7 0.1 0.022 15.7 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 PIK56097.1 - 0.017 14.9 0.2 0.063 13.1 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) DUF2207 PF09972.9 PIK56097.1 - 0.038 12.7 0.0 0.054 12.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FHIPEP PF00771.20 PIK56097.1 - 0.049 12.1 0.1 0.063 11.7 0.1 1.1 1 0 0 1 1 1 0 FHIPEP family 7TM_GPCR_Srv PF10323.9 PIK56097.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Tmemb_9 PF05434.11 PIK56097.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.3 3 0 0 3 3 2 0 TMEM9 TMEM132D_C PF15706.5 PIK56097.1 - 0.12 12.1 0.0 0.38 10.6 0.0 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Conotoxin PF02950.17 PIK56097.1 - 0.13 13.3 0.1 0.33 12.0 0.1 1.7 1 0 0 1 1 1 0 Conotoxin MAP17 PF15807.5 PIK56097.1 - 0.15 12.3 0.3 0.36 11.1 0.3 1.7 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Orf78 PF06024.12 PIK56097.1 - 0.38 11.1 1.6 0.66 10.3 0.2 2.0 1 1 1 2 2 2 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 PIK56097.1 - 0.78 9.4 3.5 0.49 10.0 0.5 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family Ig_2 PF13895.6 PIK56098.1 - 7.8e-05 22.9 1.7 0.00012 22.4 0.3 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK56098.1 - 0.00033 21.2 0.2 0.00098 19.7 0.2 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK56098.1 - 0.086 13.0 0.9 0.7 10.1 0.9 2.4 2 1 0 2 2 2 0 Immunoglobulin domain Med26 PF08711.11 PIK56099.1 - 3.6e-10 39.7 0.0 9.2e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MMgT PF10270.9 PIK56100.1 - 5.1e-16 58.8 0.0 6.1e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter DNA_photolyase PF00875.18 PIK56101.1 - 6.9e-28 97.7 0.0 1.4e-27 96.7 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.14 PIK56101.1 - 0.057 12.9 1.5 0.16 11.4 1.5 1.7 1 1 0 1 1 1 0 FAD binding domain of DNA photolyase IFT81_CH PF18383.1 PIK56102.1 - 1.7e-49 167.2 1.0 1.7e-49 167.2 1.0 3.5 4 1 0 4 4 4 1 Intraflagellar transport 81 calponin homology domain Spc7 PF08317.11 PIK56102.1 - 0.00085 18.3 11.7 0.00085 18.3 11.7 4.4 1 1 4 5 5 5 4 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.5 PIK56102.1 - 0.0022 17.6 3.0 0.0022 17.6 3.0 5.9 1 1 4 5 5 5 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain MtrG PF04210.13 PIK56102.1 - 1.1 9.2 5.8 0.95 9.4 0.0 3.5 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Uteroglobin PF01099.17 PIK56102.1 - 1.4 9.3 7.3 5.3 7.4 0.1 3.8 3 0 0 3 3 3 0 Uteroglobin family Golgin_A5 PF09787.9 PIK56102.1 - 1.9 7.9 70.1 0.016 14.7 12.5 4.0 1 1 1 3 3 3 0 Golgin subfamily A member 5 MS_channel PF00924.18 PIK56102.1 - 3.6 7.1 4.2 5.5 6.5 0.3 2.5 2 0 0 2 2 2 0 Mechanosensitive ion channel TPR_MLP1_2 PF07926.12 PIK56102.1 - 4.7 7.3 66.6 0.018 15.1 6.1 5.4 4 2 1 5 5 5 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 PIK56102.1 - 5.1 6.4 74.1 0.39 10.0 27.0 5.0 3 3 0 3 3 3 0 Growth-arrest specific micro-tubule binding NPBW PF15180.6 PIK56102.1 - 5.8 6.8 7.9 3 7.7 0.2 3.5 3 0 0 3 3 3 0 Neuropeptides B and W Rhomboid PF01694.22 PIK56103.1 - 1e-26 93.8 12.2 1.6e-26 93.1 12.2 1.3 1 0 0 1 1 1 1 Rhomboid family DUF308 PF03729.13 PIK56103.1 - 0.084 13.2 4.1 9.1 6.7 4.0 3.0 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Epimerase PF01370.21 PIK56104.1 - 3.1e-26 92.3 0.0 4.1e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 PIK56104.1 - 1.8e-24 86.3 0.0 2.3e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 PIK56104.1 - 1.7e-14 54.0 0.0 2.4e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 PIK56104.1 - 2.5e-14 53.6 0.0 5.5e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 PIK56104.1 - 6.3e-12 45.2 0.0 1.7e-11 43.8 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 PIK56104.1 - 3.7e-08 33.2 0.1 7.3e-08 32.3 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 PIK56104.1 - 5.4e-05 22.5 0.0 8.1e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 PIK56104.1 - 0.00014 21.9 0.0 0.00067 19.6 0.0 2.0 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 PIK56104.1 - 0.0012 18.4 0.1 0.0034 16.9 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 PIK56104.1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.4 1 1 0 1 1 1 0 RmlD substrate binding domain TMEM52 PF14979.6 PIK56105.1 - 0.035 14.0 0.2 0.062 13.2 0.2 1.4 1 0 0 1 1 1 0 Transmembrane 52 TMEM154 PF15102.6 PIK56106.1 - 0.0016 18.3 15.7 0.049 13.5 15.7 2.4 1 1 0 1 1 1 1 TMEM154 protein family Stevor PF17410.2 PIK56106.1 - 0.024 14.2 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM52 PF14979.6 PIK56106.1 - 0.026 14.4 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 Transmembrane 52 EphA2_TM PF14575.6 PIK56106.1 - 0.084 13.8 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RCR PF12273.8 PIK56106.1 - 0.091 13.4 0.2 1.1 10.0 0.0 2.1 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Orf78 PF06024.12 PIK56106.1 - 0.15 12.3 0.2 0.35 11.2 0.2 1.6 1 1 0 1 1 1 0 Orf78 (ac78) MAP65_ASE1 PF03999.12 PIK56106.1 - 2.8 6.5 4.9 3.7 6.1 4.9 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SKG6 PF08693.10 PIK56106.1 - 3.6 7.1 4.5 9.9 5.7 4.5 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Shisa PF13908.6 PIK56106.1 - 9.6 6.4 10.1 2.8 8.1 0.1 2.7 1 1 2 3 3 3 0 Wnt and FGF inhibitory regulator Ig_3 PF13927.6 PIK56107.1 - 2.3e-07 31.3 0.0 1.3e-06 28.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK56107.1 - 2e-06 28.0 0.0 3.1e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK56107.1 - 1.4e-05 25.1 0.0 3.7e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK56107.1 - 0.005 17.0 0.1 0.056 13.6 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56107.1 - 0.054 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain TMEM154 PF15102.6 PIK56108.1 - 1.4e-08 34.7 3.1 1.4e-08 34.7 3.1 2.1 1 1 1 2 2 2 1 TMEM154 protein family DUF4713 PF15831.5 PIK56108.1 - 6.2e-07 29.8 7.9 9.6e-07 29.2 7.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) Prominin PF05478.11 PIK56108.1 - 1e-05 23.8 0.1 1.1e-05 23.6 0.1 1.0 1 0 0 1 1 1 1 Prominin gpUL132 PF11359.8 PIK56108.1 - 2.8e-05 23.8 2.5 2.8e-05 23.8 2.5 1.6 1 1 1 2 2 2 1 Glycoprotein UL132 Shisa PF13908.6 PIK56108.1 - 7.5e-05 23.1 3.1 7.5e-05 23.1 3.1 2.5 1 1 1 2 2 1 1 Wnt and FGF inhibitory regulator Orthoreo_P10 PF07204.11 PIK56108.1 - 0.00086 19.2 0.5 0.0019 18.1 0.5 1.6 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 PIK56108.1 - 0.0025 18.6 0.0 0.0053 17.6 0.0 1.6 2 0 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM132D_C PF15706.5 PIK56108.1 - 0.008 15.9 0.5 0.015 15.1 0.5 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term FAM163 PF15069.6 PIK56108.1 - 0.0082 16.6 0.1 0.0082 16.6 0.1 2.1 2 1 0 2 2 2 1 FAM163 family Comm PF15957.5 PIK56108.1 - 0.0089 16.4 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Commissureless DUF5527 PF17665.1 PIK56108.1 - 0.013 15.0 4.4 0.013 15.0 4.4 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5527) LRRC37AB_C PF14914.6 PIK56108.1 - 0.014 15.3 0.4 0.021 14.7 0.4 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Tweety PF04906.13 PIK56108.1 - 0.023 13.4 2.1 0.033 12.9 2.1 1.2 1 0 0 1 1 1 0 Tweety Mucin PF01456.17 PIK56108.1 - 0.036 14.0 1.7 0.036 14.0 1.7 2.7 2 1 1 3 3 1 0 Mucin-like glycoprotein DUF4448 PF14610.6 PIK56108.1 - 0.052 13.3 0.1 0.071 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) RIFIN PF02009.16 PIK56108.1 - 0.07 13.0 2.0 0.088 12.7 2.0 1.1 1 0 0 1 1 1 0 Rifin SARAF PF06682.12 PIK56108.1 - 0.096 12.3 0.0 0.096 12.3 0.0 2.0 1 1 1 2 2 1 0 SOCE-associated regulatory factor of calcium homoeostasis Glycophorin_A PF01102.18 PIK56108.1 - 0.11 12.8 11.0 1.1 9.5 11.0 2.1 1 1 0 1 1 1 0 Glycophorin A CD34_antigen PF06365.12 PIK56108.1 - 0.11 12.1 0.3 0.16 11.5 0.3 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family EII-Sor PF03609.14 PIK56108.1 - 0.12 11.7 3.0 0.15 11.5 2.7 1.3 1 1 0 1 1 1 0 PTS system sorbose-specific iic component Synaptobrevin PF00957.21 PIK56108.1 - 0.13 12.1 1.3 0.21 11.4 1.3 1.3 1 0 0 1 1 1 0 Synaptobrevin MAP65_ASE1 PF03999.12 PIK56108.1 - 0.16 10.7 4.2 0.18 10.5 4.2 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TMIE PF16038.5 PIK56108.1 - 0.17 11.8 6.8 0.31 10.9 6.8 1.4 1 0 0 1 1 1 0 TMIE protein Orf78 PF06024.12 PIK56108.1 - 0.21 11.9 0.7 0.35 11.2 0.6 1.5 1 1 0 1 1 1 0 Orf78 (ac78) Stevor PF17410.2 PIK56108.1 - 0.58 9.7 7.3 0.76 9.3 7.3 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Hum_adeno_E3A PF05393.11 PIK56108.1 - 1.8 8.6 5.4 1.4 8.9 3.7 1.7 1 1 0 1 1 1 0 Human adenovirus early E3A glycoprotein RVT_1 PF00078.27 PIK56109.1 - 3.6e-25 88.8 0.0 9.6e-25 87.4 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK56110.1 - 2.1e-20 72.6 0.9 4.3e-20 71.6 0.9 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56110.1 - 5.6e-19 68.5 0.0 1.2e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK56110.1 - 0.035 14.3 0.1 0.035 14.3 0.1 2.3 3 0 0 3 3 3 0 H2C2 zinc finger DNA_pol_phi PF04931.13 PIK56111.1 - 4 5.4 4.6 4.6 5.2 4.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi GCD14 PF08704.10 PIK56112.1 - 1.1e-92 310.2 0.0 1.9e-92 309.4 0.0 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 PIK56112.1 - 6.7e-08 32.5 0.0 9.2e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK56112.1 - 0.00019 22.1 0.0 0.00038 21.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK56112.1 - 0.00028 20.7 0.0 0.00041 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14_N PF14801.6 PIK56112.1 - 0.00034 20.4 0.0 0.00085 19.1 0.0 1.7 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_11 PF08241.12 PIK56112.1 - 0.0018 18.9 0.0 0.0031 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK56112.1 - 0.0021 18.7 0.0 0.0037 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 PIK56112.1 - 0.003 18.6 0.0 0.0061 17.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK56112.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TGF_beta PF00019.20 PIK56113.1 - 2.4e-33 115.2 0.4 5.8e-33 114.0 0.0 1.8 2 0 0 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 PIK56113.1 - 1.5e-05 24.9 0.5 2e-05 24.5 0.5 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGFb_propeptide PF00688.18 PIK56114.1 - 5.7e-41 140.9 0.3 8.4e-41 140.3 0.3 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 PIK56114.1 - 1.2e-33 116.1 1.5 2.8e-33 115.0 1.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain WD40 PF00400.32 PIK56115.1 - 8.7e-15 54.9 2.9 5.3e-06 27.1 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat F-box-like PF12937.7 PIK56115.1 - 4.7e-10 39.2 0.8 8.2e-10 38.4 0.8 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK56115.1 - 6.2e-10 38.7 2.2 1.3e-09 37.7 2.2 1.6 1 0 0 1 1 1 1 F-box domain Ank_2 PF12796.7 PIK56117.1 - 1.1e-68 227.8 4.3 5.4e-17 62.2 0.1 11.7 3 2 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK56117.1 - 2.4e-51 171.5 9.9 2e-07 31.4 0.0 16.5 10 6 7 18 18 18 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK56117.1 - 2.7e-46 155.0 5.7 2.5e-05 24.4 0.0 14.8 11 4 4 15 15 15 10 Ankyrin repeats (many copies) Ank PF00023.30 PIK56117.1 - 2.6e-41 138.3 32.0 3.6e-05 24.0 0.0 16.6 17 1 1 18 18 18 8 Ankyrin repeat Ank_3 PF13606.6 PIK56117.1 - 3.4e-40 131.5 14.7 0.00015 21.9 0.0 17.1 19 0 0 19 19 19 8 Ankyrin repeat TadF PF16964.5 PIK56117.1 - 0.24 11.1 2.1 14 5.4 1.9 2.5 2 0 0 2 2 2 0 Putative tight adherence pilin protein F Ank_2 PF12796.7 PIK56118.1 - 4.5e-15 56.0 2.8 0.00011 22.7 0.0 3.7 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK56118.1 - 1.1e-12 46.9 0.0 0.00093 19.5 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 PIK56118.1 - 4.9e-11 42.6 0.0 0.00054 20.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 PIK56118.1 - 7.2e-11 42.4 0.5 1.2e-06 28.9 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK56118.1 - 2.1e-09 37.4 1.9 0.0071 16.6 0.0 4.0 2 2 1 3 3 3 2 Ankyrin repeats (many copies) PARP PF00644.20 PIK56119.1 - 3.2e-38 131.3 0.0 5.5e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 PIK56119.1 - 2.1e-23 82.9 3.6 1.2e-22 80.4 2.9 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain VID27_N PF17748.1 PIK56119.1 - 0.69 9.7 6.7 1.7 8.5 6.7 1.6 1 0 0 1 1 1 0 VID27 N-terminal region RR_TM4-6 PF06459.12 PIK56120.1 - 4.7e-37 128.3 0.0 1.2e-36 127.0 0.0 1.8 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Ion_trans PF00520.31 PIK56120.1 - 3e-06 26.7 5.5 3e-06 26.7 5.5 3.1 4 0 0 4 4 4 1 Ion transport protein GWT1 PF06423.12 PIK56120.1 - 0.061 13.4 4.0 1.1 9.3 0.0 3.3 3 0 0 3 3 3 0 GWT1 EF-hand_1 PF00036.32 PIK56121.1 - 4.7e-08 32.0 0.0 4.7e-08 32.0 0.0 2.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 PIK56121.1 - 1.9e-07 30.4 1.3 4.6e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 PIK56121.1 - 2e-05 23.9 0.1 5e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 PIK56121.1 - 8.1e-05 23.0 0.2 0.00014 22.3 0.2 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK56121.1 - 0.00015 21.6 1.5 0.0007 19.4 1.5 2.2 1 1 0 1 1 1 1 EF-hand domain pair RyR PF02026.16 PIK56122.1 - 3.7e-50 168.1 0.2 9.4e-25 86.6 0.0 2.9 2 0 0 2 2 2 2 RyR domain RIH_assoc PF08454.11 PIK56122.1 - 3.1e-32 110.4 0.0 2e-31 107.8 0.0 2.6 2 0 0 2 2 2 1 RyR and IP3R Homology associated RYDR_ITPR PF01365.21 PIK56122.1 - 3.8e-14 52.6 0.0 1.4e-13 50.7 0.0 2.1 1 0 0 1 1 1 1 RIH domain YscK PF06578.12 PIK56122.1 - 0.23 10.9 2.4 0.56 9.7 2.4 1.6 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) RYDR_ITPR PF01365.21 PIK56123.1 - 1.4e-30 106.3 0.3 3.3e-30 105.0 0.3 1.6 1 0 0 1 1 1 1 RIH domain SPRY PF00622.28 PIK56123.1 - 9.9e-16 57.9 0.2 6.3e-15 55.4 0.1 2.2 2 0 0 2 2 2 1 SPRY domain Rit1_C PF17184.4 PIK56123.1 - 0.34 10.3 1.8 0.83 9.0 0.0 2.3 3 0 0 3 3 3 0 Rit1 N-terminal domain RyR PF02026.16 PIK56124.1 - 2.9e-63 210.0 0.0 7.6e-32 109.4 0.0 2.4 2 0 0 2 2 2 2 RyR domain RYDR_ITPR PF01365.21 PIK56124.1 - 1.5e-35 122.4 2.5 2.2e-35 122.0 2.5 1.2 1 0 0 1 1 1 1 RIH domain SPRY PF00622.28 PIK56124.1 - 3.5e-29 101.3 1.7 2.3e-16 60.0 0.0 2.4 2 0 0 2 2 2 2 SPRY domain Trans_reg_C PF00486.28 PIK56124.1 - 0.019 15.1 0.0 4.6 7.4 0.0 3.4 3 0 0 3 3 3 0 Transcriptional regulatory protein, C terminal Ins145_P3_rec PF08709.11 PIK56125.1 - 1.1e-51 175.1 0.1 6.9e-49 165.9 0.1 2.4 2 0 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 PIK56125.1 - 2.5e-48 164.4 0.0 3.3e-44 151.0 0.0 2.3 2 0 0 2 2 2 2 MIR domain Imm31 PF15591.6 PIK56125.1 - 0.1 12.5 0.2 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 31 HBB PF06777.11 PIK56126.1 - 5.4e-46 156.7 0.7 6.4e-42 143.4 0.1 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 PIK56126.1 - 3.1e-45 154.4 0.0 5.9e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain DnaB_2 PF07261.11 PIK56126.1 - 0.096 12.4 0.0 0.58 9.9 0.0 2.3 3 0 0 3 3 3 0 Replication initiation and membrane attachment Metallophos PF00149.28 PIK56127.1 - 1.5e-20 74.6 1.7 1.9e-20 74.2 1.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK56127.1 - 0.00018 21.8 0.0 0.016 15.4 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 PIK56127.1 - 0.03 13.4 0.0 4 6.3 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase Aa_trans PF01490.18 PIK56130.1 - 1.5e-36 126.0 34.1 4e-36 124.6 34.1 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein MAT1 PF06391.13 PIK56131.1 - 1.5e-48 165.4 15.5 1.8e-48 165.1 15.5 1.0 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-UDP PF14569.6 PIK56131.1 - 0.021 15.0 0.2 0.041 14.0 0.2 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_5 PF17121.5 PIK56131.1 - 0.056 13.3 1.4 0.12 12.3 1.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNA_ligase_ZBD PF03119.16 PIK56131.1 - 0.071 13.1 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Forkhead PF00250.18 PIK56132.1 - 1.4e-39 134.2 0.1 2.7e-39 133.3 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain zf-RING_6 PF14835.6 PIK56132.1 - 0.042 13.7 0.3 0.087 12.7 0.3 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein CDC45 PF02724.14 PIK56132.1 - 3.7 5.7 7.3 4.8 5.4 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Sacchrp_dh_NADP PF03435.18 PIK56134.1 - 1e-20 74.3 0.0 2e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 PIK56134.1 - 0.0025 16.9 0.0 0.0039 16.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 PIK56134.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase CE2_N PF17996.1 PIK56134.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal Sacchrp_dh_NADP PF03435.18 PIK56135.1 - 7.1e-21 74.8 0.0 1.1e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF5632 PF18646.1 PIK56135.1 - 0.1 12.7 0.0 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5632) 3Beta_HSD PF01073.19 PIK56135.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 PIK56137.1 - 6e-34 117.2 0.0 3.5e-33 114.7 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK56137.1 - 9.3e-21 74.4 0.0 2.9e-20 72.8 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK56137.1 - 8.5e-10 38.8 0.1 1.1e-09 38.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK56137.1 - 0.00077 19.0 0.0 0.0015 18.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK56137.1 - 0.0017 18.6 0.1 0.0029 17.9 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 PIK56137.1 - 0.0017 18.2 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Hpr_kinase_C PF07475.12 PIK56137.1 - 0.036 13.6 0.1 0.063 12.8 0.1 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Shikimate_DH PF01488.20 PIK56137.1 - 0.036 14.1 0.9 0.071 13.2 0.9 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 PIK56137.1 - 0.048 13.0 0.1 0.079 12.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 PIK56137.1 - 0.069 13.6 0.3 0.22 12.0 0.5 1.6 2 0 0 2 2 2 0 Putative NAD(P)-binding Borrelia_P83 PF05262.11 PIK56137.1 - 0.16 10.4 0.1 0.21 10.1 0.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Pkinase_Tyr PF07714.17 PIK56138.1 - 1.1e-23 83.8 0.0 1.5e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56138.1 - 2e-16 60.2 0.2 2.7e-16 59.7 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.22 PIK56139.1 - 5.9e-10 38.5 0.0 6.4e-10 38.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK56140.1 - 2.6e-84 283.6 3.3 3.3e-84 283.3 3.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF5117 PF17148.4 PIK56140.1 - 0.018 14.9 0.1 0.029 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5117) adh_short PF00106.25 PIK56141.1 - 7.5e-36 123.4 0.0 4.3e-35 120.9 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK56141.1 - 4.2e-24 85.4 0.0 1.4e-23 83.7 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK56141.1 - 6.9e-11 42.4 0.0 1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK56141.1 - 2.9e-05 23.6 0.0 4.4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 PIK56141.1 - 0.059 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.20 PIK56141.1 - 0.088 12.9 0.6 0.26 11.4 0.6 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Hpr_kinase_C PF07475.12 PIK56141.1 - 0.1 12.1 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain 2-Hacid_dh_C PF02826.19 PIK56141.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_11 PF08241.12 PIK56142.1 - 4.9e-15 56.0 0.0 9.6e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK56142.1 - 2.1e-13 50.4 0.0 3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK56142.1 - 2.3e-10 41.0 0.0 5.1e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK56142.1 - 5.3e-07 30.3 0.0 1.1e-06 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK56142.1 - 2.2e-06 27.5 0.0 9.1e-06 25.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK56142.1 - 0.00045 19.6 0.0 0.0012 18.3 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family 7tm_1 PF00001.21 PIK56143.1 - 2e-67 227.3 0.5 3.3e-67 226.6 0.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56143.1 - 2.4e-11 43.5 10.5 2.2e-10 40.4 2.0 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK56143.1 - 1.9e-07 31.0 12.2 4.4e-07 29.8 7.2 2.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK56143.1 - 2.4e-05 24.0 5.6 2.4e-05 24.0 5.6 2.0 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 PIK56143.1 - 0.00085 19.1 0.9 0.00085 19.1 0.9 1.8 1 1 0 2 2 2 1 Olfactory receptor CcmH PF03918.14 PIK56143.1 - 0.65 9.3 0.0 0.65 9.3 0.0 2.4 3 0 0 3 3 3 0 Cytochrome C biogenesis protein CoA_binding_3 PF13727.6 PIK56143.1 - 3.4 7.6 6.0 11 6.0 0.1 3.2 3 0 0 3 3 3 0 CoA-binding domain TMEM187 PF15100.6 PIK56144.1 - 4e-20 72.4 0.2 4.4e-20 72.3 0.2 1.0 1 0 0 1 1 1 1 TMEM187 protein family VWA_N PF08399.11 PIK56145.1 - 4e-25 88.7 1.0 4e-25 88.7 1.0 2.0 2 1 0 2 2 2 1 VWA N-terminal PTE PF02126.18 PIK56145.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotriesterase family VGCC_alpha2 PF08473.11 PIK56146.1 - 4.8e-44 150.9 1.8 1.8e-25 89.6 0.0 2.0 1 1 1 2 2 2 2 Neuronal voltage-dependent calcium channel alpha 2acd dCache_1 PF02743.18 PIK56146.1 - 0.0017 18.2 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 Cache domain GAIN PF16489.5 PIK56147.1 - 0.038 13.4 0.1 0.063 12.7 0.1 1.5 1 1 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain Lipase_GDSL PF00657.22 PIK56148.1 - 5e-14 52.7 0.0 6.6e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK56148.1 - 4.7e-08 33.6 0.0 1.8e-07 31.7 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF3492 PF11997.8 PIK56148.1 - 0.14 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Lipase_GDSL PF00657.22 PIK56149.1 - 5.7e-16 59.1 0.0 9.2e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK56149.1 - 5.4e-07 30.2 0.0 1.9e-06 28.4 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family BLM10_mid PF16507.5 PIK56150.1 - 4.2e-81 273.2 0.2 9.7e-80 268.7 0.2 2.4 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 PIK56150.1 - 0.095 13.0 0.1 0.2 12.0 0.1 1.6 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 PIK56151.1 - 7.8e-38 128.3 0.0 5.1e-37 125.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) Cnd1 PF12717.7 PIK56151.1 - 0.0011 19.1 1.6 1.4 9.0 0.0 3.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 PIK56151.1 - 0.052 13.1 0.0 0.22 11.0 0.0 2.0 2 0 0 2 2 2 0 CLASP N terminal DUF1517 PF07466.11 PIK56151.1 - 0.15 12.2 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) CSN8_PSD8_EIF3K PF10075.9 PIK56152.1 - 8.5e-26 90.7 0.6 1.1e-25 90.2 0.6 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family CAP PF00188.26 PIK56153.1 - 2e-15 57.8 0.5 3.2e-15 57.1 0.5 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF999 PF06198.11 PIK56154.1 - 0.032 14.2 0.0 0.052 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF999) CAP PF00188.26 PIK56155.1 - 1.1e-13 52.1 3.5 1.5e-13 51.7 3.5 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 PIK56156.1 - 2.6e-15 57.4 5.3 4.1e-15 56.7 5.3 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 PIK56157.1 - 7.4e-22 78.5 0.7 1.4e-21 77.7 0.7 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF5359 PF17313.2 PIK56158.1 - 0.15 12.0 2.0 0.3 11.1 2.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5359) Sulfotransfer_3 PF13469.6 PIK56159.1 - 5.4e-05 23.7 0.1 0.00011 22.6 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase family DUF3131 PF11329.8 PIK56159.1 - 0.081 12.0 0.0 0.14 11.2 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3131) Phage_integrase PF00589.22 PIK56162.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family BAH PF01426.18 PIK56163.1 - 6.9e-14 51.8 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 BAH domain WD40 PF00400.32 PIK56164.1 - 2.8e-09 37.4 0.1 0.00023 21.9 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56164.1 - 0.00046 20.4 0.0 0.95 9.8 0.0 2.5 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 PIK56164.1 - 0.031 13.0 1.0 8.7 5.0 0.2 3.0 1 1 2 4 4 4 0 Nup133 N terminal like Hira PF07569.11 PIK56164.1 - 0.13 12.0 0.1 7.2 6.3 0.0 3.1 3 1 1 4 4 4 0 TUP1-like enhancer of split WD40 PF00400.32 PIK56165.1 - 3.5e-18 65.6 13.6 2.7e-06 28.0 1.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56165.1 - 0.0016 18.7 0.2 1.2 9.5 0.0 3.9 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TSP_C PF05735.12 PIK56166.1 - 3.3e-85 285.0 3.7 5.2e-85 284.4 2.6 1.8 2 0 0 2 2 2 1 Thrombospondin C-terminal region TSP_3 PF02412.18 PIK56166.1 - 8.5e-51 169.3 149.5 1.6e-11 43.7 16.3 9.5 8 1 1 9 9 9 8 Thrombospondin type 3 repeat TSP_1 PF00090.19 PIK56166.1 - 7.1e-28 96.6 60.2 1.9e-12 47.2 9.9 4.5 4 0 0 4 4 4 3 Thrombospondin type 1 domain VWC PF00093.18 PIK56166.1 - 2.7e-09 37.2 11.8 2.7e-09 37.2 11.8 6.0 5 1 0 5 5 5 1 von Willebrand factor type C domain EGF_3 PF12947.7 PIK56166.1 - 5.2e-07 29.7 5.4 5.2e-07 29.7 5.4 5.6 6 0 0 6 6 6 2 EGF domain EGF PF00008.27 PIK56166.1 - 0.00091 19.5 7.6 0.00091 19.5 7.6 6.5 5 1 1 6 6 6 2 EGF-like domain FXa_inhibition PF14670.6 PIK56167.1 - 2.3e-09 37.4 5.7 5.6e-09 36.1 5.7 1.7 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Ldl_recept_b PF00058.17 PIK56167.1 - 1.4e-07 31.8 0.3 0.11 12.9 0.2 3.4 3 0 0 3 3 3 2 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK56167.1 - 0.033 13.8 0.1 0.85 9.1 0.1 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 PIK56167.1 - 0.067 13.5 4.2 0.15 12.4 4.2 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_3 PF12947.7 PIK56167.1 - 1.6 9.0 8.4 0.98 9.7 5.9 2.0 2 0 0 2 2 2 0 EGF domain EGF_3 PF12947.7 PIK56168.1 - 2.3e-79 261.3 203.6 2.2e-09 37.3 7.8 12.3 12 0 0 12 12 12 12 EGF domain cEGF PF12662.7 PIK56168.1 - 1.2e-37 127.5 141.7 1.7e-08 34.2 4.3 12.9 12 0 0 12 12 12 12 Complement Clr-like EGF-like EGF PF00008.27 PIK56168.1 - 1.9e-35 120.8 182.0 7e-05 23.0 6.1 12.7 12 0 0 12 12 12 12 EGF-like domain EGF_MSP1_1 PF12946.7 PIK56168.1 - 1e-26 92.7 169.6 1.4e-05 25.1 10.4 12.3 12 0 0 12 12 12 11 MSP1 EGF domain 1 EGF_CA PF07645.15 PIK56168.1 - 1.3e-26 92.5 188.0 8.3e-10 38.7 8.7 12.5 10 1 2 12 12 12 11 Calcium-binding EGF domain Ldl_recept_b PF00058.17 PIK56168.1 - 6.9e-21 74.5 0.1 8.2e-13 48.6 0.1 2.4 2 0 0 2 2 2 2 Low-density lipoprotein receptor repeat class B G2F PF07474.12 PIK56168.1 - 6.8e-20 71.6 0.0 1.1e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 G2F domain Plasmod_Pvs28 PF06247.11 PIK56168.1 - 1.8e-10 41.0 143.8 0.016 15.5 5.6 12.4 12 0 0 12 12 12 9 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK56168.1 - 3.6e-08 33.6 182.4 0.075 13.3 7.8 12.4 10 2 2 12 12 12 10 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK56168.1 - 1.9e-06 28.3 157.3 0.0077 16.8 3.8 15.6 16 1 0 16 16 16 8 Human growth factor-like EGF SGL PF08450.12 PIK56168.1 - 0.0089 15.6 0.0 0.025 14.2 0.0 1.7 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NIDO PF06119.14 PIK56169.1 - 6.9e-14 52.5 0.2 2.1e-13 51.0 0.1 1.8 2 0 0 2 2 2 1 Nidogen-like zf-RING_UBOX PF13445.6 PIK56170.1 - 5.5e-06 26.3 2.1 5.5e-06 26.3 2.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK56170.1 - 6.9e-06 25.8 0.7 2.2e-05 24.2 0.7 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK56170.1 - 2.2e-05 24.3 2.9 2.2e-05 24.3 2.9 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK56170.1 - 2.5e-05 24.3 3.8 0.00013 22.0 3.8 2.3 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK56170.1 - 0.00038 20.7 4.5 0.00038 20.7 4.5 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK56170.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK56170.1 - 0.087 12.7 3.4 0.73 9.7 3.4 2.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 RT_RNaseH_2 PF17919.1 PIK56171.1 - 4.4e-37 126.1 0.1 9.2e-37 125.1 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56171.1 - 2e-33 114.8 0.1 5e-33 113.5 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56171.1 - 7.9e-31 107.3 0.0 1.3e-30 106.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK56171.1 - 3.8e-23 82.0 0.1 1.2e-22 80.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56171.1 - 1.6e-17 63.4 1.0 1.6e-17 63.4 1.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK56171.1 - 0.0016 18.6 3.5 0.0049 17.1 0.6 3.2 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 PIK56171.1 - 0.018 14.8 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MycE_N PF17843.1 PIK56171.1 - 0.084 13.4 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal Asp_protease_2 PF13650.6 PIK56173.1 - 1.6e-07 31.9 0.1 2.2e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK56173.1 - 5.5e-07 30.1 0.0 7.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 PIK56173.1 - 0.0067 16.2 0.0 0.0094 15.7 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK56173.1 - 0.073 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease PNMA PF14893.6 PIK56174.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 PNMA Galactosyl_T PF01762.21 PIK56175.1 - 1.5e-36 126.1 0.1 6.3e-27 94.7 0.1 2.2 2 0 0 2 2 2 2 Galactosyltransferase Galactosyl_T PF01762.21 PIK56176.1 - 4.9e-49 166.8 0.0 7.2e-34 117.3 0.0 2.1 2 0 0 2 2 2 2 Galactosyltransferase Spond_N PF06468.13 PIK56177.1 - 1.8e-56 191.3 1.4 1.9e-56 191.2 0.1 1.6 2 0 0 2 2 2 1 Spondin_N TSP_1 PF00090.19 PIK56177.1 - 4.7e-07 29.9 0.5 4.7e-07 29.9 0.5 2.1 1 1 1 2 2 2 1 Thrombospondin type 1 domain GST_C_3 PF14497.6 PIK56178.1 - 1.4e-17 63.7 0.3 1.9e-17 63.2 0.3 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56178.1 - 3.4e-09 36.8 0.0 5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56178.1 - 9.3e-07 28.8 0.0 2.1e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK56178.1 - 0.014 15.2 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1221 PF06760.11 PIK56179.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1221) Nop16 PF09420.10 PIK56180.1 - 3.5e-18 66.4 20.2 2.5e-13 50.6 0.9 2.9 2 1 1 3 3 3 2 Ribosome biogenesis protein Nop16 FMN_bind_2 PF04299.12 PIK56180.1 - 0.0086 15.8 0.6 0.012 15.3 0.6 1.3 1 0 0 1 1 1 1 Putative FMN-binding domain 7tm_1 PF00001.21 PIK56181.1 - 2e-67 227.3 8.6 2.8e-67 226.8 8.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56181.1 - 2.9e-12 46.5 13.1 2.5e-07 30.3 6.1 2.0 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK56181.1 - 0.0011 18.6 15.5 0.0011 18.6 15.5 2.8 2 2 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK56181.1 - 0.052 13.3 11.9 0.043 13.6 5.2 2.9 2 1 1 3 3 3 0 Olfactory receptor Podoplanin PF05808.11 PIK56181.1 - 0.063 13.4 3.3 1.8 8.6 1.3 2.2 2 0 0 2 2 2 0 Podoplanin CDK2AP PF09806.9 PIK56181.1 - 0.13 12.3 0.7 0.19 11.8 0.7 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Sec15 PF04091.12 PIK56182.1 - 5.2e-14 52.4 0.6 6.1e-14 52.1 0.6 1.1 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like COG5 PF10392.9 PIK56183.1 - 8e-05 22.8 1.5 0.0002 21.6 0.3 2.1 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 PIK56183.1 - 0.035 14.0 3.3 0.045 13.6 0.4 2.4 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain COG2 PF06148.11 PIK56183.1 - 0.37 10.9 6.1 0.3 11.2 0.8 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RP-C_C PF11800.8 PIK56183.1 - 0.75 9.9 3.7 0.46 10.6 1.7 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF5327 PF17261.2 PIK56183.1 - 2.4 8.9 8.4 1.6 9.5 4.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Ank_4 PF13637.6 PIK56185.1 - 6.1e-14 52.2 0.3 4.2e-08 33.6 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK56185.1 - 2e-12 47.0 0.2 1e-09 38.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK56185.1 - 2.2e-12 47.4 0.1 2.6e-06 27.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK56185.1 - 1.2e-10 40.6 1.1 6.4e-05 23.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 PIK56185.1 - 3.9e-09 36.6 1.8 9.1e-05 22.7 0.1 3.4 4 0 0 4 4 4 2 Ankyrin repeat zf-tcix PF14952.6 PIK56186.1 - 4.2e-14 51.9 7.1 4.2e-14 51.9 7.1 2.1 2 0 0 2 2 2 1 Putative treble-clef, zinc-finger, Zn-binding Mu-like_Com PF10122.9 PIK56186.1 - 0.042 13.3 1.0 0.086 12.3 1.0 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com zf-ribbon_3 PF13248.6 PIK56186.1 - 0.083 12.3 0.9 1.5 8.4 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain TAF4 PF05236.14 PIK56186.1 - 0.11 12.3 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family IBR PF01485.21 PIK56187.1 - 5.8e-14 52.1 37.3 3.7e-08 33.5 11.2 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 PIK56187.1 - 0.00041 20.1 1.4 0.00041 20.1 1.4 3.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK56187.1 - 0.0013 19.1 5.0 0.0013 19.1 5.0 4.2 5 0 0 5 5 5 2 Ring finger domain zf-RING_UBOX PF13445.6 PIK56187.1 - 0.0098 15.9 2.7 0.0098 15.9 2.7 4.3 5 0 0 5 5 5 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK56187.1 - 0.012 15.5 3.5 0.012 15.5 3.5 4.3 4 0 0 4 4 4 0 zinc-RING finger domain FOXP-CC PF16159.5 PIK56188.1 - 1.5e-33 115.2 2.6 1.5e-33 115.2 2.6 2.6 2 1 1 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.18 PIK56188.1 - 2.7e-27 94.9 0.0 5.7e-27 93.8 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain Zap1_zf2 PF18217.1 PIK56188.1 - 0.014 15.4 0.8 0.036 14.1 0.8 1.8 1 0 0 1 1 1 0 Zap1 zinc finger 2 MBOAT PF03062.19 PIK56189.1 - 5.6e-17 62.1 14.8 1.8e-16 60.4 14.8 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family ACOX PF01756.19 PIK56190.1 - 3.5e-53 179.8 0.2 5.6e-52 175.9 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 PIK56190.1 - 6.9e-21 75.1 0.3 1.5e-20 74.0 0.3 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 PIK56190.1 - 2.6e-08 34.0 0.0 4.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK56190.1 - 0.0048 17.5 0.0 0.058 14.1 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain DUF5553 PF17707.1 PIK56191.1 - 0.071 12.5 3.0 0.1 12.0 3.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5553) Paramyxo_ncap PF00973.19 PIK56191.1 - 1.1 8.0 5.0 1.6 7.5 5.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SpoIIIAH PF12685.7 PIK56191.1 - 1.5 8.6 9.5 2.7 7.8 9.5 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein Pes-10 PF07149.11 PIK56191.1 - 2.2 7.3 12.8 2.9 6.9 12.8 1.1 1 0 0 1 1 1 0 Pes-10 UPF0242 PF06785.11 PIK56191.1 - 5.2 7.1 10.0 8.3 6.5 10.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GET2 PF08690.10 PIK56191.1 - 6.7 6.3 10.0 8.3 6.0 10.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Mcm10 PF09332.11 PIK56192.1 - 2.3e-56 191.7 25.4 2.3e-56 191.7 25.4 3.2 3 1 1 4 4 4 2 Mcm10 replication factor zf-primase PF09329.11 PIK56192.1 - 4.1e-17 61.7 9.0 9.6e-17 60.5 9.0 1.7 1 0 0 1 1 1 1 Primase zinc finger SH3_1 PF00018.28 PIK56192.1 - 0.13 11.9 1.0 0.44 10.2 0.1 2.2 1 1 1 2 2 2 0 SH3 domain zf-C2H2_8 PF15909.5 PIK56192.1 - 0.5 10.7 7.2 0.2 12.0 3.0 2.5 3 0 0 3 3 3 0 C2H2-type zinc ribbon Gal-3-0_sulfotr PF06990.11 PIK56193.1 - 1.2e-65 222.0 0.1 1.9e-65 221.4 0.1 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK56193.1 - 0.0063 16.9 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK56194.1 - 1.7e-70 238.0 0.1 2.1e-70 237.7 0.1 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK56194.1 - 0.022 14.7 0.4 0.047 13.6 0.0 1.7 2 0 0 2 2 2 0 Sulfotransferase family SASA PF03629.18 PIK56195.1 - 1.3e-12 47.8 0.0 1.1e-10 41.6 0.0 2.6 1 1 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase VPS9 PF02204.18 PIK56196.1 - 0.0036 17.5 0.0 0.012 15.8 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain XPC-binding PF09280.11 PIK56196.1 - 0.011 15.5 0.3 0.052 13.3 0.1 2.2 2 1 0 2 2 2 0 XPC-binding domain MSP7_C PF12948.7 PIK56196.1 - 0.51 11.0 6.6 0.35 11.5 2.3 2.7 2 2 0 2 2 2 0 MSP7-like protein C-terminal domain Pkinase PF00069.25 PIK56198.1 - 1.5e-29 103.2 0.0 1.8e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56198.1 - 2e-17 63.3 0.0 3.5e-17 62.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK56198.1 - 7.2e-06 26.1 0.5 0.12 12.3 0.0 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 PIK56198.1 - 0.006 15.6 0.1 0.024 13.7 0.0 1.8 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 PIK56198.1 - 0.012 15.0 0.3 0.017 14.4 0.3 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 PIK56198.1 - 0.027 14.1 0.0 2.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 PIK56198.1 - 0.15 10.8 0.0 0.54 9.0 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Y_phosphatase PF00102.27 PIK56199.1 - 3.3e-36 125.1 0.9 3.6e-36 124.9 0.9 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK56199.1 - 0.00056 19.7 0.2 0.0011 18.7 0.2 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK56199.1 - 0.0032 17.5 0.0 0.0038 17.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK56200.1 - 1.1e-26 93.8 0.8 7.3e-26 91.2 0.8 1.9 1 1 0 1 1 1 1 Protein-tyrosine phosphatase RT_RNaseH_2 PF17919.1 PIK56201.1 - 2.7e-29 101.2 0.0 6.7e-29 99.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56201.1 - 2e-27 95.5 0.0 3.5e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56201.1 - 4.9e-27 94.9 0.0 9.8e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK56201.1 - 0.00018 21.5 0.1 0.00018 21.5 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain BCNT PF07572.12 PIK56201.1 - 0.1 12.7 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Bucentaur or craniofacial development rve PF00665.26 PIK56202.1 - 2.7e-22 79.2 0.0 5.1e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56202.1 - 9.7e-16 57.6 0.7 1.7e-15 56.8 0.7 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK56202.1 - 2.7e-11 43.4 0.1 4.1e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK56202.1 - 0.00013 21.7 0.0 0.00027 20.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Gifsy-2 PF13856.6 PIK56202.1 - 0.071 13.5 0.0 0.65 10.4 0.0 2.4 2 0 0 2 2 2 0 ATP-binding sugar transporter from pro-phage DDE_Tnp_IS240 PF13610.6 PIK56202.1 - 0.11 12.8 0.0 0.73 10.1 0.0 2.3 3 0 0 3 3 3 0 DDE domain zf-CCHC_2 PF13696.6 PIK56203.1 - 0.066 13.1 4.4 0.14 12.0 4.4 1.6 1 0 0 1 1 1 0 Zinc knuckle Macoilin PF09726.9 PIK56203.1 - 9.3 4.7 8.4 11 4.4 8.4 1.0 1 0 0 1 1 1 0 Macoilin family Y_phosphatase PF00102.27 PIK56204.1 - 1.6e-105 351.9 3.9 1.8e-56 191.3 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK56204.1 - 1.7e-08 34.3 0.1 0.0039 17.0 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK56204.1 - 0.00014 21.9 0.0 0.24 11.3 0.0 2.6 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK56204.1 - 0.00019 21.6 0.0 0.0057 16.8 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate Stevor PF17410.2 PIK56204.1 - 0.036 13.6 0.7 0.072 12.6 0.7 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Y_phosphatase2 PF03162.13 PIK56204.1 - 0.046 13.3 0.4 2.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF4750 PF15938.5 PIK56204.1 - 6 6.6 5.8 14 5.4 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) Big_3 PF07523.12 PIK56205.1 - 0.0025 18.1 16.0 0.89 9.9 1.3 4.2 1 1 4 5 5 5 4 Bacterial Ig-like domain (group 3) CBM_25 PF03423.13 PIK56205.1 - 0.019 15.2 1.9 3.3 8.0 0.3 3.2 1 1 3 4 4 4 0 Carbohydrate binding domain (family 25) Diphtheria_T PF02764.14 PIK56205.1 - 0.39 10.7 8.6 6.8 6.7 0.1 4.0 1 1 4 5 5 5 0 Diphtheria toxin, T domain Trp_ring PF18669.1 PIK56205.1 - 0.86 9.8 23.3 6.5 7.0 0.4 5.6 6 0 0 6 6 6 0 Trimeric autotransporter adhesin Trp ring domain PEGA PF08308.11 PIK56205.1 - 1.1 9.2 14.1 2 8.4 0.5 4.0 2 1 2 4 4 4 0 PEGA domain Y_phosphatase PF00102.27 PIK56206.1 - 1.9e-51 174.9 1.0 1.9e-51 174.9 1.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK56206.1 - 0.0006 19.6 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK56206.1 - 0.023 14.8 0.0 0.091 12.9 0.0 2.0 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK56206.1 - 0.024 14.6 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK56207.1 - 3.2e-09 36.7 0.7 4.1e-09 36.3 0.2 1.4 2 0 0 2 2 2 1 Protein-tyrosine phosphatase TUDOR_5 PF18359.1 PIK56207.1 - 0.095 12.4 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 PX PF00787.24 PIK56208.1 - 2.1e-11 43.8 0.3 4.2e-11 42.8 0.2 1.5 2 0 0 2 2 2 1 PX domain Pkinase PF00069.25 PIK56208.1 - 1.9e-06 27.4 0.4 3.1e-06 26.8 0.2 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56208.1 - 0.062 12.6 0.2 0.084 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase ABC_transp_aux PF09822.9 PIK56209.1 - 4.7e-10 39.4 0.0 7.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.14 PIK56209.1 - 0.005 15.7 0.0 0.24 10.2 0.0 2.1 1 1 0 2 2 2 2 Oligosaccharyltransferase 48 kDa subunit beta ThuA PF06283.11 PIK56209.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Trehalose utilisation DUF4159 PF13709.6 PIK56209.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) DUF3657 PF12394.8 PIK56210.1 - 3.1e-13 50.1 0.8 6.8e-13 49.0 0.8 1.6 1 0 0 1 1 1 1 Protein FAM135 Sulfotransfer_2 PF03567.14 PIK56211.1 - 0.00028 20.9 0.1 0.00035 20.5 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family LegC3_N PF18654.1 PIK56211.1 - 0.059 12.6 0.1 0.087 12.0 0.1 1.2 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain Sulfotransfer_2 PF03567.14 PIK56212.1 - 9.3e-07 29.0 0.1 1.7e-06 28.1 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK56213.1 - 1.3e-11 44.9 0.7 4.3e-11 43.2 0.7 1.7 1 1 0 1 1 1 1 Sulfotransferase family MOZ_SAS PF01853.18 PIK56214.1 - 2.1e-63 213.2 1.4 3.7e-63 212.4 1.4 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 PIK56214.1 - 2.2e-23 81.6 1.1 2.2e-23 81.6 1.1 2.2 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 PIK56214.1 - 0.0029 18.0 0.0 0.0052 17.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FYRN PF05964.14 PIK56215.1 - 5.8e-16 58.1 0.4 1.3e-15 56.9 0.4 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 PIK56215.1 - 3.1e-14 52.9 0.0 7e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 F/Y rich C-terminus HARE-HTH PF05066.13 PIK56215.1 - 5.1e-08 33.2 0.0 1e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain fn2 PF00040.19 PIK56215.1 - 0.07 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type II domain LUD_dom PF02589.15 PIK56215.1 - 0.15 11.8 0.2 0.24 11.1 0.2 1.3 1 0 0 1 1 1 0 LUD domain ACOX PF01756.19 PIK56216.1 - 3.9e-36 124.3 0.0 4.6e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 Acyl-CoA oxidase Arm PF00514.23 PIK56217.1 - 0.67 10.1 14.6 16 5.7 0.3 7.7 9 1 1 10 10 10 0 Armadillo/beta-catenin-like repeat Herpes_BLLF1 PF05109.13 PIK56217.1 - 0.69 7.8 6.6 0.97 7.3 6.6 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Acyl-CoA_ox_N PF14749.6 PIK56218.1 - 0.00088 19.8 0.1 0.0016 19.0 0.1 1.4 1 1 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Maelstrom PF13017.6 PIK56219.1 - 8.9e-19 68.0 0.0 1.3e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.10 PIK56219.1 - 1.2e-11 45.1 0.8 1.2e-11 45.1 0.8 2.0 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.19 PIK56219.1 - 0.00014 22.2 0.5 0.00029 21.2 0.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box Methyltransf_23 PF13489.6 PIK56220.1 - 1.2e-07 31.7 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK56220.1 - 0.0052 17.4 0.0 0.46 11.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK56220.1 - 0.0053 16.6 0.0 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK56220.1 - 0.024 15.4 0.0 0.076 13.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M26_N PF05342.14 PIK56220.1 - 0.094 12.1 0.2 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region Taeniidae_ag PF05596.11 PIK56220.1 - 0.16 12.0 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Taeniidae antigen Peptidase_A17 PF05380.13 PIK56221.1 - 5.4e-41 140.3 0.0 9.2e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK56221.1 - 6.3e-08 32.8 0.0 1.4e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56221.1 - 4e-05 23.7 0.8 8.3e-05 22.6 0.8 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK56221.1 - 0.039 14.0 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56221.1 - 0.087 13.1 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Herpes_BLLF1 PF05109.13 PIK56222.1 - 0.0014 16.7 21.5 0.0017 16.4 21.5 1.0 1 0 0 1 1 1 1 Herpes virus major outer envelope glycoprotein (BLLF1) Hid1 PF12722.7 PIK56222.1 - 0.95 7.5 5.2 0.99 7.4 5.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Myofilin PF15929.5 PIK56223.1 - 0.0008 19.8 0.3 0.0012 19.2 0.3 1.2 1 0 0 1 1 1 1 Myofilin Dimer_Tnp_hAT PF05699.14 PIK56225.1 - 6.1e-05 22.7 0.4 0.00012 21.8 0.4 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK56226.1 - 1.1e-05 25.2 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) zf-BED PF02892.15 PIK56226.1 - 0.021 14.8 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 BED zinc finger BIR PF00653.21 PIK56226.1 - 0.083 13.6 0.0 0.22 12.2 0.0 1.7 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain Ig_3 PF13927.6 PIK56227.1 - 3.7e-16 59.5 3.2 3.8e-07 30.6 0.0 4.3 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK56227.1 - 1.9e-12 47.1 1.1 8e-05 22.6 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK56227.1 - 2.5e-12 46.8 2.3 0.00014 21.9 0.3 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK56227.1 - 1.9e-09 37.7 5.6 8.5e-06 26.0 0.0 4.3 5 0 0 5 5 5 2 Immunoglobulin domain V-set PF07686.17 PIK56227.1 - 7.3e-08 32.5 4.1 3.4e-05 24.0 0.2 3.7 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56227.1 - 0.00046 19.7 1.7 2.1 7.9 0.1 3.6 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK56227.1 - 0.00068 19.6 1.2 0.21 11.7 0.2 3.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK56227.1 - 0.0012 18.9 0.6 0.05 13.7 0.1 2.8 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Alpha_adaptinC2 PF02883.20 PIK56227.1 - 0.0063 16.8 0.7 0.27 11.5 0.2 3.2 2 1 1 3 3 3 1 Adaptin C-terminal domain Ig_3 PF13927.6 PIK56228.1 - 7.8e-17 61.6 4.0 5.2e-09 36.6 0.0 4.4 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK56228.1 - 2.5e-12 46.7 0.9 6.6e-05 22.9 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK56228.1 - 2.5e-11 43.6 5.8 1.9e-06 27.9 0.1 3.5 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK56228.1 - 5.5e-11 42.6 4.8 5.1e-08 33.1 0.0 3.9 5 0 0 5 5 5 2 Immunoglobulin domain V-set PF07686.17 PIK56228.1 - 3.9e-08 33.4 3.4 0.00025 21.2 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56228.1 - 8.8e-06 25.2 1.0 0.57 9.8 0.0 4.3 4 0 0 4 4 4 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK56228.1 - 0.00027 21.0 2.9 0.015 15.3 0.5 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK56228.1 - 0.0061 16.6 1.1 0.68 10.0 0.0 3.2 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 PIK56228.1 - 0.012 15.7 0.0 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin C2-set domain Alpha_adaptinC2 PF02883.20 PIK56228.1 - 0.028 14.7 0.2 1.8 8.9 0.1 3.6 3 2 1 4 4 4 0 Adaptin C-terminal domain Ig_4 PF16680.5 PIK56228.1 - 0.075 13.3 0.1 1.4 9.3 0.0 2.6 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Ig_3 PF13927.6 PIK56229.1 - 2.2e-17 63.4 0.8 4.4e-09 36.8 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK56229.1 - 2.9e-13 49.7 0.4 5e-06 26.5 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK56229.1 - 4.4e-11 42.8 0.4 0.00078 19.6 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK56229.1 - 7.6e-10 39.0 1.5 1.5e-06 28.5 0.0 3.2 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK56229.1 - 1.7e-09 37.9 0.3 0.00011 22.3 0.1 3.1 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56229.1 - 0.00088 18.8 0.1 0.77 9.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set PF05790.15 PIK56229.1 - 0.0023 18.1 0.0 1.9 8.8 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 PIK56229.1 - 0.004 17.2 0.1 0.39 10.8 0.0 2.6 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Alpha_adaptinC2 PF02883.20 PIK56229.1 - 0.094 13.0 0.2 2 8.8 0.0 3.0 4 0 0 4 4 4 0 Adaptin C-terminal domain DUF2207 PF09972.9 PIK56229.1 - 0.19 10.5 0.6 1.3 7.7 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ig_3 PF13927.6 PIK56230.1 - 9.2e-05 23.0 7.2 0.0046 17.5 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK56230.1 - 0.00014 22.0 2.3 0.0004 20.5 0.6 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK56230.1 - 0.00022 21.2 0.1 0.0018 18.3 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK56230.1 - 0.00048 20.3 0.3 0.00048 20.3 0.3 4.2 4 0 0 4 4 4 1 Immunoglobulin domain Ig_2 PF13895.6 PIK56230.1 - 0.0036 17.6 1.6 0.073 13.4 0.5 2.9 2 1 0 2 2 2 1 Immunoglobulin domain DUF2140 PF09911.9 PIK56230.1 - 0.07 12.7 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) SID-1_RNA_chan PF13965.6 PIK56230.1 - 0.071 11.5 0.7 0.12 10.8 0.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 zf-RRN7 PF11781.8 PIK56230.1 - 0.15 11.8 1.4 15 5.4 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Insulin_TMD PF17870.1 PIK56230.1 - 0.35 11.0 3.1 0.73 9.9 3.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment UBA_e1_thiolCys PF10585.9 PIK56230.1 - 0.42 10.5 7.3 0.024 14.6 0.9 2.2 2 1 0 2 2 2 0 Ubiquitin-activating enzyme active site Mem_trans PF03547.18 PIK56230.1 - 2.5 6.4 5.2 6.3 5.1 5.2 1.6 1 1 0 1 1 1 0 Membrane transport protein Methyltransf_11 PF08241.12 PIK56231.1 - 4.3e-07 30.5 0.0 7.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK56231.1 - 2.1e-06 28.3 0.0 4.1e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK56231.1 - 4e-06 27.5 0.1 1e-05 26.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK56231.1 - 2.4e-05 24.2 0.0 3.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK56231.1 - 0.00026 20.6 0.0 0.00046 19.8 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 PIK56231.1 - 0.00028 20.4 0.0 0.00035 20.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK56231.1 - 0.0011 18.8 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 PIK56231.1 - 0.0013 18.1 0.1 0.0034 16.7 0.1 1.6 1 1 0 1 1 1 1 rRNA small subunit methyltransferase G DREV PF05219.12 PIK56231.1 - 0.085 11.9 0.0 0.18 10.9 0.0 1.6 1 1 1 2 2 2 0 DREV methyltransferase Exo_endo_phos_2 PF14529.6 PIK56232.1 - 2.6e-12 46.6 0.1 3.9e-12 46.0 0.1 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HNOB PF07700.15 PIK56232.1 - 0.02 14.9 0.1 0.03 14.3 0.1 1.2 1 0 0 1 1 1 0 Haem-NO-binding Exo_endo_phos PF03372.23 PIK56232.1 - 0.077 12.5 0.0 0.12 11.9 0.0 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family EamA PF00892.20 PIK56233.1 - 3e-06 27.4 9.2 9.4e-05 22.6 2.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 PIK56233.1 - 0.0093 15.5 0.4 0.012 15.1 0.4 1.3 1 1 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 PIK56234.1 - 1.4e-13 51.2 23.9 9.3e-10 38.8 17.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 PIK56234.1 - 0.0019 17.7 0.9 0.0019 17.7 0.9 2.0 1 1 1 2 2 2 1 Solute carrier family 35 YibE_F PF07907.11 PIK56234.1 - 0.041 13.4 17.6 0.083 12.4 4.9 2.2 2 0 0 2 2 2 0 YibE/F-like protein DUF2070 PF09843.9 PIK56234.1 - 0.87 7.8 11.0 1.1 7.5 11.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TspO_MBR PF03073.15 PIK56234.1 - 1.1 9.3 13.6 1.3 9.0 7.1 2.3 1 1 1 2 2 2 0 TspO/MBR family DUF4231 PF14015.6 PIK56234.1 - 2.6 8.6 7.2 1.7 9.1 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Phage_holin_3_6 PF07332.11 PIK56234.1 - 9.8 6.3 15.7 0.37 10.8 1.9 2.6 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III 7tm_1 PF00001.21 PIK56235.1 - 1.8e-32 112.7 8.7 2.3e-32 112.4 8.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK56235.1 - 4e-15 56.1 12.7 4.9e-15 55.9 12.7 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK56235.1 - 4.8e-06 26.1 7.5 6.3e-06 25.8 7.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK56235.1 - 0.0049 16.3 7.1 0.0062 15.9 6.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Pkinase PF00069.25 PIK56236.1 - 6.5e-67 225.7 0.0 9e-67 225.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56236.1 - 4.9e-39 134.2 0.0 7.3e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK56236.1 - 1.3e-08 34.5 0.0 2.3e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 PIK56236.1 - 0.00055 19.9 0.0 0.0056 16.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK56236.1 - 0.00057 18.8 0.0 0.0019 17.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK56236.1 - 0.016 14.1 0.4 0.036 13.0 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 PIK56236.1 - 0.082 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 PIK56237.1 - 1.7e-15 56.6 0.1 2.6e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-synt_G PF04718.15 PIK56238.1 - 9.3e-23 80.9 0.0 1.1e-22 80.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Integrase_H2C2 PF17921.1 PIK56239.1 - 2.6e-19 69.1 0.1 5.4e-19 68.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56239.1 - 2.3e-17 63.3 0.0 5.2e-17 62.1 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK56239.1 - 0.00016 21.8 0.0 0.00033 20.8 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK56239.1 - 0.0019 17.9 0.1 0.014 15.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK56240.1 - 2.9e-37 126.7 0.0 6.1e-37 125.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56240.1 - 3e-27 95.6 0.0 6e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK56240.1 - 3.3e-26 91.6 0.0 7.2e-26 90.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase V-set PF07686.17 PIK56241.1 - 2e-05 24.7 0.1 4.3e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF4888 PF16229.5 PIK56241.1 - 0.0045 17.0 0.2 3.3 7.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4888) Ig_3 PF13927.6 PIK56241.1 - 0.022 15.4 0.1 0.022 15.4 0.1 3.0 4 0 0 4 4 4 0 Immunoglobulin domain Tme5_EGF_like PF09064.10 PIK56241.1 - 9.2 6.3 10.3 8.6 6.3 1.4 3.0 2 2 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like RT_RNaseH_2 PF17919.1 PIK56242.1 - 7.2e-32 109.4 0.0 1.5e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56242.1 - 2.6e-30 105.6 0.0 4e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK56242.1 - 7.6e-26 90.5 0.0 1.4e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Ank_4 PF13637.6 PIK56243.1 - 3e-15 56.4 0.1 2.2e-11 44.1 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK56243.1 - 1.2e-14 54.6 0.4 1.6e-13 51.1 0.2 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK56243.1 - 4.2e-13 49.1 1.0 4.2e-05 23.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK56243.1 - 1.3e-09 38.1 1.4 2.2e-05 24.6 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK56243.1 - 2.1e-08 33.7 0.0 0.0024 18.2 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat PRKG1_interact PF15898.5 PIK56243.1 - 0.00083 20.2 1.5 0.00083 20.2 1.5 5.5 6 0 0 6 6 6 1 cGMP-dependent protein kinase interacting domain NYD-SP28 PF14772.6 PIK56243.1 - 0.0025 17.8 0.2 0.0025 17.8 0.2 4.6 7 0 0 7 7 7 1 Sperm tail PKcGMP_CC PF16808.5 PIK56243.1 - 0.012 15.4 2.2 0.012 15.4 2.2 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 PIK56243.1 - 0.14 12.5 0.2 0.14 12.5 0.2 3.0 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Fib_alpha PF08702.10 PIK56243.1 - 0.32 11.2 0.0 0.32 11.2 0.0 3.0 5 0 0 5 5 5 0 Fibrinogen alpha/beta chain family zf-C2H2_jaz PF12171.8 PIK56244.1 - 2.4e-09 37.2 5.9 2.4e-09 37.2 5.9 1.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK56244.1 - 0.002 18.4 6.5 0.0036 17.6 6.1 1.7 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK56244.1 - 0.44 11.0 4.2 0.79 10.2 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type AAA_lid_2 PF17863.1 PIK56245.1 - 0.091 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA lid domain Glyco_hydro_2_N PF02837.18 PIK56245.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.6 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_38N PF01074.22 PIK56246.1 - 3.4e-44 151.4 3.6 3.1e-19 69.5 0.0 3.2 3 0 0 3 3 3 3 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 PIK56246.1 - 2.8e-13 49.8 0.1 6.3e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 PIK56247.1 - 6.7e-45 153.8 0.1 1.4e-44 152.7 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro38C2 PF17677.1 PIK56247.1 - 1.7e-11 44.1 0.1 1.1e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Biopterin_H PF00351.21 PIK56248.1 - 6.6e-169 561.2 0.3 1.1e-157 524.3 0.1 2.1 2 0 0 2 2 2 2 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 PIK56248.1 - 3.1e-07 30.1 0.0 6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 ACT domain MLANA PF14991.6 PIK56251.1 - 0.0067 16.7 0.5 0.016 15.4 0.3 1.8 1 1 0 1 1 1 1 Protein melan-A TMEM154 PF15102.6 PIK56251.1 - 0.023 14.6 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family GAPT PF11770.8 PIK56251.1 - 0.052 13.4 0.1 0.15 12.0 0.1 1.8 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) WD40 PF00400.32 PIK56252.1 - 9.3e-17 61.1 10.8 1.1e-06 29.2 0.2 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat WD40_like PF17005.5 PIK56252.1 - 0.0031 16.9 0.0 0.042 13.2 0.0 2.3 2 1 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 PIK56252.1 - 0.013 15.8 1.1 0.6 10.4 0.3 3.2 1 1 3 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Chordopox_G3 PF06129.12 PIK56253.1 - 0.0071 17.0 0.7 18 6.1 0.1 3.5 2 1 1 3 3 3 2 Chordopoxvirus G3 protein TMEM154 PF15102.6 PIK56253.1 - 0.046 13.6 0.1 0.046 13.6 0.1 2.5 1 1 1 2 2 2 0 TMEM154 protein family PRELI PF04707.14 PIK56254.1 - 1.1e-17 64.2 0.0 1.3e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family Annexin PF00191.20 PIK56255.1 - 2.1e-90 296.8 10.5 2.8e-27 94.6 0.3 4.5 4 0 0 4 4 4 4 Annexin Ank_2 PF12796.7 PIK56255.1 - 4.1e-13 49.7 0.1 4.2e-11 43.3 0.1 2.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Fn3_assoc PF13287.6 PIK56255.1 - 1.1e-12 47.9 0.1 2.5e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 Fn3 associated Ank_5 PF13857.6 PIK56255.1 - 2.6e-12 46.7 0.8 9.1e-06 25.9 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) CHB_HEX_C_1 PF13290.6 PIK56255.1 - 7e-12 45.2 0.5 1.7e-11 43.9 0.5 1.7 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Ank PF00023.30 PIK56255.1 - 4.2e-09 36.5 0.2 0.0033 17.8 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK56255.1 - 8.5e-09 35.0 0.1 0.0052 17.2 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 PIK56255.1 - 9.7e-09 35.6 0.0 0.01 16.4 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) GP67 PF17634.2 PIK56255.1 - 0.029 14.8 0.3 0.029 14.8 0.3 3.7 4 0 0 4 4 4 0 Gene product 67 PBP_GOBP PF01395.22 PIK56255.1 - 0.055 13.6 3.1 0.6 10.3 0.5 2.5 2 0 0 2 2 2 0 PBP/GOBP family FAM176 PF14851.6 PIK56255.1 - 0.95 9.1 9.1 0.15 11.7 3.7 2.3 2 0 0 2 2 2 0 FAM176 family DED PF01335.21 PIK56256.1 - 1.1e-17 64.1 0.7 2.3e-17 63.0 0.7 1.5 1 0 0 1 1 1 1 Death effector domain HYR PF02494.16 PIK56256.1 - 0.44 10.9 2.6 0.78 10.1 0.2 2.5 3 0 0 3 3 3 0 HYR domain LRR_8 PF13855.6 PIK56257.1 - 5.6e-48 160.5 41.7 5.2e-14 51.8 0.2 4.3 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK56257.1 - 3.2e-14 53.0 3.5 2.9e-08 33.7 0.4 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56257.1 - 1e-12 48.0 25.2 0.00014 22.2 4.0 5.2 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56257.1 - 5.8e-08 32.4 8.3 0.0019 17.7 2.2 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK56257.1 - 4.8e-05 23.3 18.3 17 6.4 0.0 8.3 8 1 0 8 8 8 2 Leucine Rich Repeat Baculo_11_kDa PF06143.11 PIK56257.1 - 0.063 12.9 4.8 0.15 11.6 4.8 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM154 PF15102.6 PIK56257.1 - 0.067 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family EVI2A PF05399.11 PIK56257.1 - 0.17 11.4 2.4 0.29 10.7 2.4 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) RT_RNaseH_2 PF17919.1 PIK56258.1 - 3.1e-29 101.0 0.0 5.9e-29 100.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56258.1 - 4e-26 91.3 0.0 9.6e-26 90.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK56258.1 - 9.6e-20 70.4 1.8 3.4e-19 68.7 1.8 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56258.1 - 3.1e-14 53.2 0.0 8e-14 51.9 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK56258.1 - 2e-10 40.6 0.0 0.00022 20.8 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK56258.1 - 0.0002 21.5 1.0 0.001 19.2 0.9 2.2 2 0 0 2 2 2 1 H2C2 zinc finger LRR_8 PF13855.6 PIK56260.1 - 2.6e-51 171.2 26.8 3.6e-14 52.3 0.1 4.4 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK56260.1 - 7.6e-15 54.8 27.4 2.2e-05 24.7 4.2 5.1 2 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK56260.1 - 4e-13 49.4 0.5 1.5e-07 31.4 0.0 2.5 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK56260.1 - 5.4e-10 39.0 4.4 0.001 18.6 0.2 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK56260.1 - 4.6e-08 32.5 10.7 9.3 7.2 0.0 7.5 8 0 0 8 8 8 3 Leucine Rich Repeat LRRNT PF01462.18 PIK56260.1 - 0.2 11.4 0.7 2.6 7.8 0.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 PIK56260.1 - 0.21 11.7 16.0 3.8 7.8 0.7 5.5 7 0 0 7 7 7 0 Leucine Rich repeat F-box-like PF12937.7 PIK56261.1 - 1e-10 41.3 0.3 1e-10 41.3 0.3 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK56261.1 - 0.00013 21.8 3.3 0.00014 21.6 0.0 2.9 3 0 0 3 3 3 1 F-box domain F-box_5 PF18511.1 PIK56261.1 - 0.00094 18.7 0.1 0.0022 17.5 0.1 1.6 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 PIK56261.1 - 0.052 14.0 2.5 2.2 8.8 0.4 3.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF4637 PF15470.6 PIK56262.1 - 0.00034 20.4 1.8 0.00069 19.4 1.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) CDC45 PF02724.14 PIK56262.1 - 0.032 12.5 6.7 0.035 12.4 6.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 PIK56262.1 - 0.52 9.5 0.9 0.78 8.9 0.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RRN3 PF05327.11 PIK56262.1 - 0.94 7.9 13.2 1.3 7.4 12.6 1.3 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GCIP PF13324.6 PIK56262.1 - 1.5 8.4 8.1 2 8.0 8.0 1.4 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting ORC_WH_C PF18137.1 PIK56262.1 - 1.8 8.6 7.4 10 6.2 0.0 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal FAM176 PF14851.6 PIK56262.1 - 5.7 6.6 9.5 0.58 9.8 4.0 2.1 2 0 0 2 2 2 0 FAM176 family Tub_N PF16322.5 PIK56262.1 - 8.4 6.7 22.2 0.23 11.8 8.3 2.1 2 0 0 2 2 2 0 Tubby N-terminal HEAT_2 PF13646.6 PIK56263.1 - 0.00041 20.7 0.5 0.17 12.3 0.1 3.2 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 PIK56263.1 - 0.048 13.9 2.7 2.1 8.8 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat DRIM PF07539.12 PIK56264.1 - 2.1e-153 512.0 7.6 2.1e-153 512.0 7.6 2.2 3 0 0 3 3 3 1 Down-regulated in metastasis Arm PF00514.23 PIK56264.1 - 0.0053 16.8 0.0 8.2 6.6 0.0 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat BssS PF13991.6 PIK56264.1 - 0.038 14.1 0.1 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 BssS protein family CARD_2 PF16739.5 PIK56265.1 - 4.2e-08 33.1 0.0 1.1e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Caspase recruitment domain 2OG-FeII_Oxy_3 PF13640.6 PIK56266.1 - 3.2e-13 50.4 3.4 8.2e-13 49.1 3.4 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RasGEF_N_2 PF14663.6 PIK56268.1 - 4.4e-35 120.3 1.3 3.8e-34 117.3 0.2 2.5 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 PIK56268.1 - 9.5e-31 105.9 0.7 1.4e-29 102.1 0.3 2.9 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 RICTOR_M PF14666.6 PIK56268.1 - 1.1e-29 102.3 5.0 1.7e-26 92.0 0.4 4.8 4 1 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_N PF14664.6 PIK56269.1 - 1.2e-46 159.4 1.3 1.5e-46 159.1 1.3 1.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term Pkinase PF00069.25 PIK56270.1 - 7e-38 130.5 0.1 1.1e-18 67.6 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56270.1 - 2.7e-09 36.7 0.1 2.6e-05 23.7 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase AAA_32 PF13654.6 PIK56270.1 - 0.17 10.6 6.3 0.32 9.7 6.3 1.3 1 0 0 1 1 1 0 AAA domain RIO1 PF01163.22 PIK56270.1 - 4.4 6.9 6.9 4.7 6.8 0.0 2.3 2 0 0 2 2 2 0 RIO1 family YAF2_RYBP PF17219.3 PIK56271.1 - 8.7e-15 54.0 2.8 1.9e-14 53.0 2.8 1.6 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.18 PIK56271.1 - 6.7e-09 34.9 1.9 1.2e-08 34.1 1.9 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 PIK56271.1 - 0.047 14.0 1.8 0.077 13.3 1.8 1.3 1 0 0 1 1 1 0 C1 domain Ephrin_rec_like PF07699.13 PIK56271.1 - 0.096 12.5 0.8 0.19 11.5 0.8 1.4 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_1 PF00001.21 PIK56272.1 - 6.4e-23 81.4 0.0 9.9e-22 77.5 0.0 2.0 1 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56272.1 - 0.0013 18.2 3.1 0.0013 18.2 3.1 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK56272.1 - 0.0032 16.8 2.1 0.0032 16.8 2.1 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw OFeT_1 PF16955.5 PIK56272.1 - 0.0037 17.0 1.4 0.61 9.7 0.2 2.5 2 0 0 2 2 2 2 Ferrous iron uptake permease, iron-lead transporter Peptidase_C3 PF00548.20 PIK56272.1 - 0.014 15.3 4.5 0.88 9.5 0.4 2.3 2 0 0 2 2 2 0 3C cysteine protease (picornain 3C) Porin_2 PF02530.14 PIK56272.1 - 0.019 14.3 11.6 0.052 12.8 3.5 2.1 2 0 0 2 2 2 0 Porin subfamily DUF4233 PF14017.6 PIK56272.1 - 0.084 13.2 9.6 1.7 9.0 0.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4233) RtxA PF07634.11 PIK56272.1 - 0.1 13.2 0.1 0.32 11.6 0.1 1.9 1 0 0 1 1 1 0 RtxA repeat NADHdeh_related PF10125.9 PIK56272.1 - 0.13 11.6 5.3 5.1 6.4 0.1 3.0 3 0 0 3 3 3 0 NADH dehydrogenase I, subunit N related protein Orf78 PF06024.12 PIK56272.1 - 1.6 9.1 6.4 37 4.7 0.4 3.7 3 0 0 3 3 3 0 Orf78 (ac78) DUF2839 PF10999.8 PIK56272.1 - 4.3 7.8 5.3 52 4.3 0.5 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) Serpentine_r_xa PF03383.15 PIK56272.1 - 5.3 7.0 9.3 0.36 10.8 0.2 3.2 4 0 0 4 4 4 0 Caenorhabditis serpentine receptor-like protein, class xa PspC PF04024.12 PIK56272.1 - 6.5 6.7 7.5 79 3.2 0.2 3.7 3 0 0 3 3 3 0 PspC domain 7tm_1 PF00001.21 PIK56273.1 - 6.3e-08 32.3 0.0 1.1e-05 24.9 0.0 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) DUF3278 PF11683.8 PIK56273.1 - 0.21 11.7 1.8 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) Orf78 PF06024.12 PIK56273.1 - 1 9.7 5.1 0.64 10.3 0.7 2.5 2 1 0 2 2 2 0 Orf78 (ac78) Phage_int_SAM_4 PF13495.6 PIK56274.1 - 0.062 13.8 0.0 15 6.1 0.0 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain SpvD PF05563.12 PIK56274.1 - 0.096 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD SPA PF08616.10 PIK56275.1 - 6.8e-11 42.1 0.0 1.5e-10 41.0 0.0 1.5 2 0 0 2 2 2 1 Stabilization of polarity axis DENN PF02141.21 PIK56275.1 - 1.5e-05 25.0 0.1 0.00011 22.2 0.1 2.0 1 1 0 1 1 1 1 DENN (AEX-3) domain Avl9 PF09794.9 PIK56275.1 - 0.0038 16.0 0.0 0.0049 15.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 RIH_assoc PF08454.11 PIK56276.1 - 0.014 15.3 1.5 0.036 13.9 0.9 2.1 2 0 0 2 2 2 0 RyR and IP3R Homology associated Laminin_B PF00052.18 PIK56276.1 - 0.019 14.9 0.1 0.93 9.4 0.0 2.6 2 0 0 2 2 2 0 Laminin B (Domain IV) Atx10homo_assoc PF09759.9 PIK56277.1 - 1.5e-09 37.8 0.1 2.1e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain wnt PF00110.19 PIK56278.1 - 5.2e-116 387.6 26.4 6e-116 387.3 26.4 1.0 1 0 0 1 1 1 1 wnt family Myosin_tail_1 PF01576.19 PIK56279.1 - 0.00015 19.7 78.5 0.00015 19.7 78.5 2.3 1 1 1 2 2 2 1 Myosin tail TSC22 PF01166.18 PIK56279.1 - 0.01 16.1 1.8 0.01 16.1 1.8 9.7 9 2 1 10 10 10 0 TSC-22/dip/bun family UPF0242 PF06785.11 PIK56279.1 - 0.013 15.6 22.3 0.013 15.6 22.3 6.5 1 1 5 7 7 7 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 PIK56279.1 - 0.041 13.9 141.4 0.91 9.5 25.0 8.4 1 1 6 8 8 8 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RTC PF01137.21 PIK56279.1 - 0.12 11.5 0.1 0.23 10.7 0.1 1.3 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase DUF1643 PF07799.12 PIK56279.1 - 6.9 6.9 8.8 2 8.6 0.1 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1643) DcpS_C PF11969.8 PIK56281.1 - 4.2e-31 107.8 2.3 5.2e-31 107.5 2.0 1.3 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-MYND PF01753.18 PIK56282.1 - 3.5e-10 39.8 17.0 6.9e-10 38.9 17.0 1.5 1 0 0 1 1 1 1 MYND finger CDI PF02234.19 PIK56282.1 - 0.11 12.8 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor zf-HIT PF04438.16 PIK56282.1 - 0.51 10.2 7.1 0.98 9.4 7.1 1.5 1 0 0 1 1 1 0 HIT zinc finger zf-tcix PF14952.6 PIK56282.1 - 0.94 9.2 6.2 1.7 8.3 6.2 1.4 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding zf-C6H2 PF15801.5 PIK56282.1 - 4.5 7.7 11.9 11 6.5 11.9 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PH PF00169.29 PIK56283.1 - 6e-14 52.4 0.0 6.9e-14 52.2 0.0 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK56283.1 - 2.3e-05 24.7 0.5 7.2e-05 23.2 0.5 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain PsbP PF01789.16 PIK56283.1 - 0.0029 17.8 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 PsbP PH_9 PF15410.6 PIK56283.1 - 0.003 17.9 0.1 0.003 17.9 0.1 1.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 PIK56283.1 - 0.0049 17.2 0.0 0.0064 16.8 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_4 PF15404.6 PIK56283.1 - 0.014 15.2 0.0 0.016 15.0 0.0 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 PIK56283.1 - 0.023 14.6 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 PH domain PH_13 PF16652.5 PIK56283.1 - 0.041 13.7 0.1 0.047 13.5 0.1 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain F5_F8_type_C PF00754.25 PIK56285.1 - 7.5e-13 48.7 0.9 1.2e-12 48.1 0.9 1.3 1 0 0 1 1 1 1 F5/8 type C domain Sortilin-Vps10 PF15902.5 PIK56286.1 - 0.021 13.6 1.1 0.037 12.8 1.1 1.6 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, BNR PF02012.20 PIK56286.1 - 2.2 8.6 5.9 23 5.5 0.2 3.1 3 0 0 3 3 3 0 BNR/Asp-box repeat ThiF PF00899.21 PIK56288.1 - 7.3e-95 317.0 0.0 6.4e-53 179.6 0.0 2.1 2 0 0 2 2 2 2 ThiF family E1_FCCH PF16190.5 PIK56288.1 - 1.6e-34 117.9 0.2 4.8e-34 116.4 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain UBA_e1_thiolCys PF10585.9 PIK56288.1 - 2.3e-08 34.3 0.0 4.3e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UBA_e1_thiolCys PF10585.9 PIK56289.1 - 6.9e-45 153.9 0.0 7.4e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site INCA1 PF15142.6 PIK56289.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 INCA1 E1_UFD PF09358.10 PIK56290.1 - 1.1e-35 122.2 0.4 2.1e-35 121.3 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain UBA_e1_thiolCys PF10585.9 PIK56290.1 - 1.5e-14 54.6 0.5 4.2e-14 53.1 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site ThiF PF00899.21 PIK56290.1 - 5.2e-11 42.4 0.0 8.1e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Viral_DNA_Zn_bi PF03728.13 PIK56290.1 - 0.0097 16.4 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 1 Viral DNA-binding protein, zinc binding domain SseC PF04888.12 PIK56290.1 - 0.13 11.9 0.1 0.26 10.8 0.0 1.4 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Plant_NMP1 PF06694.11 PIK56291.1 - 1.2e-13 50.8 1.2 1.5e-11 44.0 1.2 2.9 1 1 0 1 1 1 1 Plant nuclear matrix protein 1 (NMP1) DUF3150 PF11348.8 PIK56291.1 - 0.011 15.0 0.0 0.37 10.0 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3150) DUF3924 PF13062.6 PIK56291.1 - 0.05 13.5 0.3 0.05 13.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) NleF_casp_inhib PF16809.5 PIK56291.1 - 0.057 13.3 0.5 0.12 12.3 0.5 1.5 1 0 0 1 1 1 0 NleF caspase inhibitor Golgin_A5 PF09787.9 PIK56292.1 - 6.8e-111 370.6 26.8 6.8e-111 370.6 26.8 3.2 1 1 2 3 3 3 1 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 PIK56292.1 - 0.001 19.1 20.3 0.001 19.1 20.3 5.5 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 PIK56292.1 - 0.0089 15.8 13.8 0.0089 15.8 13.8 5.0 1 1 2 4 4 4 2 Domain of unknown function (DUF4201) PKcGMP_CC PF16808.5 PIK56292.1 - 0.052 13.4 0.4 0.052 13.4 0.4 5.3 6 1 1 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DNA_pol_B_thumb PF14791.6 PIK56292.1 - 0.061 13.5 0.6 9.1 6.5 0.0 3.3 3 0 0 3 3 3 0 DNA polymerase beta thumb S_2TMBeta PF18153.1 PIK56292.1 - 0.12 12.2 0.3 0.38 10.5 0.3 1.8 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain AAA_13 PF13166.6 PIK56292.1 - 1.1 7.8 61.5 0.17 10.5 28.4 2.4 1 1 1 2 2 2 0 AAA domain Atg14 PF10186.9 PIK56292.1 - 8.5 5.4 77.3 6 5.8 16.5 4.4 1 1 3 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 HOOK PF05622.12 PIK56292.1 - 9.1 4.3 84.8 0.62 8.2 18.0 3.7 1 1 1 3 3 3 0 HOOK protein TPR_12 PF13424.6 PIK56293.1 - 2e-11 44.0 0.1 1.4e-05 25.2 0.1 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56293.1 - 2.7e-09 36.4 2.1 0.094 12.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56293.1 - 1.1e-08 34.6 4.8 0.13 12.5 0.3 3.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56293.1 - 4.8e-08 32.5 6.8 0.0029 17.4 0.8 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56293.1 - 6.3e-07 29.0 0.1 2 8.6 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56293.1 - 5e-05 23.0 0.1 0.0072 16.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Consortin_C PF15281.6 PIK56293.1 - 0.0014 18.6 6.4 0.0014 18.6 6.4 2.9 2 1 0 2 2 2 1 Consortin C-terminus TPR_11 PF13414.6 PIK56293.1 - 0.0024 17.5 0.3 2.5 7.9 0.1 2.7 3 0 0 3 3 3 2 TPR repeat Orf78 PF06024.12 PIK56293.1 - 6.3 7.2 11.5 5.1 7.4 0.5 3.6 3 1 0 3 3 3 0 Orf78 (ac78) FMN_dh PF01070.18 PIK56294.1 - 4.9e-135 450.0 0.0 5.5e-135 449.9 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK56294.1 - 2e-08 33.6 0.8 4e-08 32.7 0.8 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK56294.1 - 7.8e-05 22.0 0.4 0.00012 21.3 0.4 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase TMP-TENI PF02581.17 PIK56294.1 - 0.043 13.1 0.0 0.69 9.2 0.0 2.7 3 0 0 3 3 3 0 Thiamine monophosphate synthase His_biosynth PF00977.21 PIK56294.1 - 0.099 12.1 0.2 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein LRR_4 PF12799.7 PIK56295.1 - 0.00077 19.8 0.1 0.18 12.3 0.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK56295.1 - 0.0029 17.9 1.2 11 7.0 0.1 3.6 3 0 0 3 3 3 2 Leucine Rich Repeat SNAP PF14938.6 PIK56296.1 - 2.4e-67 227.3 21.3 2.6e-38 132.1 13.6 2.7 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 PIK56296.1 - 8.6e-06 25.5 7.6 0.18 12.0 0.1 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat Sel1 PF08238.12 PIK56296.1 - 2e-05 25.1 2.3 1.3 9.8 0.0 3.5 3 0 0 3 3 3 2 Sel1 repeat TPR_7 PF13176.6 PIK56296.1 - 5.3e-05 22.9 4.2 6.8 7.0 0.3 5.0 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56296.1 - 9.1e-05 22.4 7.4 1.1 9.7 0.2 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56296.1 - 0.00014 22.1 7.3 1.4 9.3 1.0 3.9 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK56296.1 - 0.00027 21.4 6.9 0.63 10.8 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat NSF PF02071.20 PIK56296.1 - 0.00068 19.9 23.3 0.44 11.5 1.0 6.0 6 0 0 6 6 5 3 Aromatic-di-Alanine (AdAR) repeat DUF2076 PF09849.9 PIK56296.1 - 0.0042 17.2 1.0 0.0082 16.2 1.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF4368 PF14287.6 PIK56296.1 - 0.0086 16.4 0.2 0.77 10.1 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4368) TPR_1 PF00515.28 PIK56296.1 - 0.015 15.1 12.3 0.4 10.6 0.2 4.3 3 1 2 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56296.1 - 0.099 12.6 3.5 43 4.2 0.0 4.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56296.1 - 0.15 11.8 11.8 3.5 7.4 0.1 4.9 5 1 1 6 6 6 0 TPR repeat NRBF2_MIT PF17169.4 PIK56296.1 - 0.76 10.0 4.6 0.73 10.1 0.2 2.9 2 1 1 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 Spatacsin_C PF14649.6 PIK56296.1 - 0.78 8.8 7.8 11 5.0 7.4 2.7 1 1 0 1 1 1 0 Spatacsin C-terminus Exonuc_VII_S PF02609.16 PIK56296.1 - 0.79 9.8 6.7 11 6.2 0.0 3.6 4 0 0 4 4 4 0 Exonuclease VII small subunit Peptidase_A17 PF05380.13 PIK56299.1 - 6.1e-34 117.4 0.0 1.4e-33 116.2 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK56299.1 - 2.4e-09 37.1 4.2 2.4e-09 37.1 4.2 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain DNA_pol_viral_C PF00336.18 PIK56299.1 - 0.043 13.2 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain HA PF03457.14 PIK56299.1 - 0.16 12.3 1.4 0.32 11.4 0.0 2.3 2 0 0 2 2 2 0 Helicase associated domain zf-H2C2 PF09337.10 PIK56299.1 - 0.16 12.2 4.1 0.088 13.0 1.1 2.1 2 0 0 2 2 2 0 H2C2 zinc finger Asp_protease_2 PF13650.6 PIK56300.1 - 0.039 14.6 0.1 0.087 13.5 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK56300.1 - 1.7 8.9 7.0 0.11 12.6 0.9 2.4 2 0 0 2 2 2 0 Zinc knuckle OEP PF02321.18 PIK56301.1 - 0.0013 18.6 3.4 0.0022 17.8 3.4 1.3 1 0 0 1 1 1 1 Outer membrane efflux protein DUF1759 PF03564.15 PIK56301.1 - 0.0014 18.5 3.2 0.0037 17.2 0.0 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF1759) AAA_23 PF13476.6 PIK56301.1 - 1.1 9.7 9.5 3 8.3 9.5 1.7 1 0 0 1 1 1 0 AAA domain SH2 PF00017.24 PIK56303.1 - 4.3e-42 142.1 0.3 6.5e-20 71.0 0.0 3.1 2 0 0 2 2 2 2 SH2 domain RasGAP PF00616.19 PIK56303.1 - 9.9e-32 110.3 1.1 2.8e-21 76.2 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 PIK56303.1 - 1.4e-18 67.3 1.1 3.5e-18 66.0 0.7 2.0 2 0 0 2 2 2 1 PH domain C2 PF00168.30 PIK56303.1 - 1.9e-10 40.9 0.0 4.9e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain PH_8 PF15409.6 PIK56303.1 - 2.2e-06 27.8 0.2 6.1e-06 26.4 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_1 PF00018.28 PIK56303.1 - 9.2e-06 25.2 0.1 2.6e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK56303.1 - 0.0019 18.0 0.1 0.0055 16.5 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain PH_11 PF15413.6 PIK56303.1 - 0.0068 16.8 3.9 0.052 14.0 3.9 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 PIK56303.1 - 0.21 11.9 1.3 0.7 10.3 1.3 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain SRCR PF00530.18 PIK56304.1 - 0.0008 19.9 0.0 0.0025 18.3 0.0 1.8 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain OSK PF17182.4 PIK56305.1 - 6.2e-08 32.1 0.1 9.3e-08 31.5 0.1 1.2 1 0 0 1 1 1 1 OSK domain Lipase_GDSL PF00657.22 PIK56305.1 - 3.7e-05 23.8 0.0 4.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 PIK56305.1 - 3.9e-05 24.1 0.0 5.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF459 PF04311.13 PIK56305.1 - 0.0055 15.7 0.0 0.012 14.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF459) PHD PF00628.29 PIK56305.1 - 0.22 11.4 5.8 1.3 8.9 4.6 2.8 2 1 0 2 2 2 0 PHD-finger PRCH PF03967.13 PIK56306.1 - 0.0064 16.7 0.0 0.009 16.2 0.0 1.2 1 0 0 1 1 1 1 Photosynthetic reaction centre, H-chain N-terminal region DUF2207 PF09972.9 PIK56306.1 - 0.16 10.7 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SRCR PF00530.18 PIK56307.1 - 8.9e-13 48.6 0.0 1.5e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK56307.1 - 0.16 12.5 0.0 0.61 10.7 0.0 1.8 1 1 1 2 2 2 0 Scavenger receptor cysteine-rich domain zf-H2C2_5 PF13909.6 PIK56308.1 - 0.0032 17.2 5.4 0.0041 16.8 3.8 2.1 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK56308.1 - 0.014 15.8 1.4 0.014 15.8 1.4 2.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.7 PIK56308.1 - 0.054 13.9 5.7 0.086 13.3 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type VPS38 PF17649.1 PIK56308.1 - 0.085 11.7 0.7 0.1 11.5 0.7 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 zf-C2H2_4 PF13894.6 PIK56308.1 - 0.089 13.7 7.4 1.1 10.3 0.9 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK56308.1 - 0.09 13.5 3.0 0.28 11.9 3.0 1.7 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 PIK56308.1 - 0.33 11.5 8.5 2 9.0 1.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF629 PF04780.12 PIK56308.1 - 0.63 8.5 5.0 0.46 9.0 2.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_2 PF12756.7 PIK56308.1 - 0.64 10.4 10.1 1.9 8.9 0.9 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CEBP_ZZ PF16366.5 PIK56308.1 - 2.1 8.6 9.1 1.6 9.0 1.0 2.6 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain RVT_1 PF00078.27 PIK56309.1 - 3.6e-15 56.1 0.0 4.2e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF86 PF01934.17 PIK56310.1 - 0.01 15.7 0.3 0.024 14.5 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF86 IZUMO PF15005.6 PIK56310.1 - 0.048 14.2 0.1 0.078 13.5 0.1 1.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated OrfB_IS605 PF01385.19 PIK56310.1 - 0.052 13.8 0.5 0.11 12.7 0.4 1.7 1 1 1 2 2 2 0 Probable transposase CBFB_NFYA PF02045.15 PIK56310.1 - 6.9 7.4 8.1 7.2 7.3 5.5 2.3 2 1 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF1736 PF08409.11 PIK56311.1 - 0.069 13.2 13.7 20 5.3 0.1 6.2 1 1 6 7 7 7 0 Domain of unknown function (DUF1736) FAM150 PF15129.6 PIK56311.1 - 0.41 10.8 6.3 50 4.1 0.5 3.6 1 1 4 5 5 5 0 FAM150 family Myf5 PF12232.8 PIK56311.1 - 4.4 8.2 12.9 5.2e+02 1.5 0.0 6.3 6 1 1 7 7 7 0 Myogenic determination factor 5 Ependymin PF00811.18 PIK56312.1 - 8.1e-09 35.8 0.4 0.00031 21.0 0.0 2.6 2 1 1 3 3 3 2 Ependymin RT_RNaseH_2 PF17919.1 PIK56313.1 - 6.2e-37 125.6 0.0 9.8e-37 125.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56313.1 - 2.9e-34 117.5 0.0 4.5e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56313.1 - 6.6e-20 71.6 0.1 1.7e-19 70.3 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flu_PB1 PF00602.17 PIK56313.1 - 0.17 10.0 0.0 0.23 9.5 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 ANAPC4_WD40 PF12894.7 PIK56314.1 - 0.00012 22.3 0.2 0.00032 20.9 0.2 1.8 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain MitMem_reg PF13012.6 PIK56315.1 - 7.7e-28 97.2 0.1 1.4e-27 96.3 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 PIK56315.1 - 5.3e-22 78.0 0.1 1.1e-21 77.0 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4743 PF15916.5 PIK56315.1 - 0.078 12.9 0.1 0.28 11.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) FAM194 PF14977.6 PIK56316.1 - 1.2e-64 217.3 0.0 1.9e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 FAM194 protein GCR PF02155.15 PIK56316.1 - 0.02 13.9 0.5 0.041 12.9 0.5 1.4 1 0 0 1 1 1 0 Glucocorticoid receptor DNA_pol_phi PF04931.13 PIK56316.1 - 9.5 4.2 9.4 16 3.4 9.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi CH PF00307.31 PIK56317.1 - 3.1e-11 43.4 0.1 1.8e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain CDC24 PF06395.11 PIK56317.1 - 0.041 14.1 1.6 0.14 12.5 0.0 2.4 2 0 0 2 2 2 0 CDC24 Calponin CAMSAP_CH PF11971.8 PIK56317.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain Tmp39 PF10271.9 PIK56317.1 - 0.34 9.9 2.1 0.74 8.8 0.1 2.0 2 0 0 2 2 2 0 Putative transmembrane protein V_ATPase_I PF01496.19 PIK56318.1 - 0.15 9.9 0.7 0.25 9.2 0.0 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FAM76 PF16046.5 PIK56318.1 - 0.6 9.4 4.6 0.21 10.9 0.1 1.9 2 0 0 2 2 2 0 FAM76 protein LRR_8 PF13855.6 PIK56319.1 - 5.7e-22 77.2 15.2 7.8e-10 38.4 0.1 3.9 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK56319.1 - 3.5e-18 65.4 19.0 4.2e-05 23.8 4.6 4.9 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK56319.1 - 3.2e-08 33.0 19.2 0.5 11.1 1.3 7.3 7 1 0 7 7 7 4 Leucine Rich Repeat LRR_6 PF13516.6 PIK56319.1 - 0.00025 20.8 25.2 0.17 12.0 1.5 6.3 7 0 0 7 7 7 3 Leucine Rich repeat LRR_8 PF13855.6 PIK56320.1 - 4e-31 106.6 29.6 5e-14 51.8 5.7 5.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK56320.1 - 5.6e-12 45.7 0.3 4.7e-07 29.8 0.0 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56320.1 - 1.7e-11 44.2 32.1 0.00069 20.0 0.1 5.7 1 1 7 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56320.1 - 6.4e-07 29.0 6.4 0.00072 19.1 1.3 3.3 2 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK56320.1 - 0.16 12.6 31.4 2.3 9.1 0.2 8.2 7 2 1 8 8 8 0 Leucine Rich Repeat Ras PF00071.22 PIK56321.1 - 6.1e-44 149.5 0.8 6e-32 110.5 0.1 2.6 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK56321.1 - 7e-17 61.8 0.2 7.2e-08 32.7 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase VWA_2 PF13519.6 PIK56321.1 - 1.2e-07 32.3 0.0 0.0024 18.5 0.0 3.1 2 1 1 3 3 3 2 von Willebrand factor type A domain Sec23_trunk PF04811.15 PIK56321.1 - 2.6e-06 27.2 0.1 0.0039 16.8 0.0 2.4 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain RsgA_GTPase PF03193.16 PIK56321.1 - 4.9e-06 26.5 0.0 1.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase zf-Sec23_Sec24 PF04810.15 PIK56321.1 - 1.8e-05 24.7 0.7 5.8e-05 23.1 0.7 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Arf PF00025.21 PIK56321.1 - 0.00011 21.8 0.1 0.2 11.1 0.0 2.9 2 1 1 3 3 3 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK56321.1 - 0.00056 20.0 0.1 0.14 12.2 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase VWA PF00092.28 PIK56321.1 - 0.002 18.4 1.4 0.11 12.7 0.5 3.4 2 1 0 2 2 2 1 von Willebrand factor type A domain Sec23_BS PF08033.12 PIK56321.1 - 0.0043 17.8 0.3 0.015 16.0 0.3 2.0 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain AAA_16 PF13191.6 PIK56321.1 - 0.11 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain PHD PF00628.29 PIK56321.1 - 0.11 12.4 1.6 0.33 10.9 1.6 1.8 1 0 0 1 1 1 0 PHD-finger FeoB_N PF02421.18 PIK56321.1 - 0.28 10.7 3.9 5.3 6.6 0.0 4.0 5 1 0 5 5 5 0 Ferrous iron transport protein B LRR_8 PF13855.6 PIK56322.1 - 4.7e-29 99.9 24.0 2.2e-13 49.7 5.9 4.1 1 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK56322.1 - 1.5e-12 47.5 27.4 0.00028 21.2 4.7 4.5 4 0 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56322.1 - 6.4e-06 25.8 9.2 0.0088 15.6 0.9 3.1 1 1 2 3 3 3 3 Leucine-rich repeat DUF4400 PF14348.6 PIK56322.1 - 0.0073 15.8 1.6 0.012 15.1 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4400) BatD PF13584.6 PIK56322.1 - 0.0082 15.0 0.5 0.012 14.5 0.5 1.1 1 0 0 1 1 1 1 Oxygen tolerance LRR_1 PF00560.33 PIK56322.1 - 0.024 15.1 26.0 2.5 9.0 0.5 7.5 5 2 1 6 6 6 0 Leucine Rich Repeat DUF5383 PF17355.2 PIK56322.1 - 0.11 12.9 5.1 0.23 11.9 5.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5383) Orf78 PF06024.12 PIK56322.1 - 0.13 12.6 10.6 0.033 14.5 7.1 1.7 1 1 1 2 2 2 0 Orf78 (ac78) DUF2207 PF09972.9 PIK56322.1 - 0.16 10.7 1.9 0.24 10.1 1.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EVI2A PF05399.11 PIK56322.1 - 0.21 11.1 11.6 0.33 10.5 11.6 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) MSC PF09402.10 PIK56322.1 - 0.27 10.6 1.4 0.41 10.1 1.4 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain DUF508 PF04370.12 PIK56322.1 - 0.32 10.7 10.4 5.2 6.8 10.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF508) DUF3446 PF11928.8 PIK56322.1 - 0.33 11.3 20.0 0.85 10.0 20.0 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain DUF4448 PF14610.6 PIK56322.1 - 0.46 10.2 2.9 0.82 9.4 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 PIK56322.1 - 0.49 10.3 22.0 0.024 14.5 15.3 1.9 1 1 1 2 2 2 0 TMEM154 protein family Amnionless PF14828.6 PIK56322.1 - 1.2 7.9 5.6 1.8 7.3 5.6 1.2 1 0 0 1 1 1 0 Amnionless SR-25 PF10500.9 PIK56322.1 - 3.8 7.0 25.1 6.5 6.3 25.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Renin_r PF07850.14 PIK56322.1 - 4 8.1 8.8 15 6.3 8.8 2.0 1 1 0 1 1 1 0 Renin receptor-like protein SelP_N PF04592.14 PIK56322.1 - 4.3 6.7 11.3 6.9 6.0 11.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Macoilin PF09726.9 PIK56322.1 - 4.8 5.6 11.2 6.8 5.1 11.2 1.2 1 0 0 1 1 1 0 Macoilin family RIFIN PF02009.16 PIK56322.1 - 6.3 6.6 15.9 13 5.5 15.9 1.5 1 0 0 1 1 1 0 Rifin DUF1635 PF07795.11 PIK56322.1 - 7.4 6.4 8.3 12 5.6 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Rax2 PF12768.7 PIK56322.1 - 8.2 5.8 12.1 3.3 7.1 8.9 1.8 1 1 0 1 1 1 0 Cortical protein marker for cell polarity Ras PF00071.22 PIK56323.1 - 3e-31 108.2 0.5 1.1e-21 77.1 0.1 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 PIK56323.1 - 9.1e-17 61.4 0.0 5e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK56323.1 - 0.0018 18.2 0.0 0.0044 17.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Sec23_BS PF08033.12 PIK56323.1 - 0.0021 18.7 0.1 0.0069 17.1 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain MMR_HSR1 PF01926.23 PIK56323.1 - 0.084 13.0 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase LRR_8 PF13855.6 PIK56324.1 - 1.2e-34 117.8 23.7 8.8e-15 54.2 4.2 5.3 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK56324.1 - 1.7e-18 66.4 22.9 7.4e-05 23.0 1.2 5.4 6 0 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK56324.1 - 3.4e-17 62.6 1.9 2.3e-10 40.5 0.0 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK56324.1 - 1.5e-06 27.9 24.7 6.7 7.7 0.8 8.9 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK56324.1 - 5.6e-06 26.0 6.2 0.00058 19.4 1.0 3.2 1 1 1 3 3 3 2 Leucine-rich repeat DUF4280 PF14107.6 PIK56324.1 - 0.031 15.1 0.3 1.1 10.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4280) LRR_6 PF13516.6 PIK56324.1 - 0.73 10.1 19.5 2.6 8.3 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich repeat LRR_2 PF07723.13 PIK56324.1 - 4 8.3 9.8 30 5.5 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 PIK56325.1 - 4.8e-33 112.7 40.9 6.7e-14 51.4 7.8 4.6 1 1 3 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK56325.1 - 3e-13 49.9 2.3 4.7e-08 33.1 0.0 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56325.1 - 1.4e-12 47.6 36.6 1.1e-05 25.7 5.3 5.7 2 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56325.1 - 2.1e-06 27.4 9.5 0.0042 16.6 1.2 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK56325.1 - 0.00037 20.7 37.9 0.12 13.0 0.5 9.1 8 1 1 9 9 9 4 Leucine Rich Repeat RVT_1 PF00078.27 PIK56326.1 - 3.4e-10 39.8 0.0 4.6e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK56326.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) ALMS_motif PF15309.6 PIK56327.1 - 8.3e-12 45.7 20.0 8.3e-12 45.7 20.0 5.4 5 0 0 5 5 5 1 ALMS motif Ribosomal_L2_C PF03947.18 PIK56328.1 - 5.3e-46 155.9 3.5 8.5e-46 155.3 3.5 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 PIK56328.1 - 3.2e-21 75.1 0.2 1.3e-20 73.1 0.1 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain 7tm_2 PF00002.24 PIK56329.1 - 5.2e-42 143.8 6.8 6.7e-42 143.5 6.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK56329.1 - 6.2e-15 55.5 4.6 6.2e-15 55.5 4.6 1.9 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif PIG-P PF08510.12 PIK56329.1 - 0.095 12.6 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 PIG-P RVT_1 PF00078.27 PIK56331.1 - 1.1e-10 41.4 0.0 1.9e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK56331.1 - 8.3e-06 25.3 0.0 0.00015 21.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) Fis1_TPR_C PF14853.6 PIK56332.1 - 1.2e-23 82.9 0.1 2e-23 82.2 0.1 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 PIK56332.1 - 3e-12 46.0 0.0 5.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 PIK56332.1 - 0.00038 20.3 0.0 0.00084 19.3 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Terminase_1 PF03354.15 PIK56332.1 - 0.22 10.1 0.0 0.31 9.6 0.0 1.2 1 0 0 1 1 1 0 Phage Terminase BTB PF00651.31 PIK56333.1 - 7.6e-23 80.9 0.2 1.5e-15 57.3 0.0 2.2 2 0 0 2 2 2 2 BTB/POZ domain DUF3342 PF11822.8 PIK56333.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) LRR_6 PF13516.6 PIK56334.1 - 0.06 13.4 11.0 0.9 9.8 0.2 4.9 5 0 0 5 5 5 0 Leucine Rich repeat DnaJ PF00226.31 PIK56335.1 - 1.6e-24 85.8 1.8 1.6e-24 85.8 1.8 2.8 3 0 0 3 3 3 1 DnaJ domain TPR_2 PF07719.17 PIK56335.1 - 2.4e-23 80.3 17.1 0.032 14.3 0.0 8.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56335.1 - 5.7e-22 76.6 19.4 0.00096 18.9 0.1 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56335.1 - 5.7e-19 67.2 11.7 0.11 13.3 0.0 8.0 4 3 4 8 8 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56335.1 - 2e-16 60.4 12.1 4.8e-05 23.9 1.3 6.1 5 3 1 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56335.1 - 1.8e-15 55.8 18.1 0.03 14.5 0.0 8.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56335.1 - 2.7e-15 56.6 22.3 7.7e-07 29.5 0.1 5.9 2 2 3 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56335.1 - 7.8e-14 51.1 27.8 0.0081 15.8 0.5 7.9 6 2 3 9 9 8 5 TPR repeat TPR_9 PF13371.6 PIK56335.1 - 1.8e-10 40.8 8.3 0.0016 18.6 0.3 6.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56335.1 - 1.9e-08 34.5 20.0 0.0035 17.6 2.1 6.1 4 3 2 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56335.1 - 3.8e-08 32.8 16.3 0.001 18.9 0.0 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK56335.1 - 1.6e-07 31.5 14.7 0.15 12.3 1.9 4.7 3 2 1 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 PIK56335.1 - 4.3e-06 27.0 20.1 3.7 8.4 0.2 8.8 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_21 PF09976.9 PIK56335.1 - 2e-05 24.4 20.7 0.0016 18.2 7.5 4.2 2 2 3 5 5 5 3 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 PIK56335.1 - 6.9e-05 23.1 20.5 1.9 8.9 1.9 6.8 3 2 4 7 7 7 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK56335.1 - 0.00028 20.9 7.2 0.93 9.6 0.2 5.5 4 1 1 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat ANAPC5 PF12862.7 PIK56335.1 - 0.00031 20.8 4.0 0.052 13.6 0.0 4.2 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 5 TPR_17 PF13431.6 PIK56335.1 - 0.0004 20.5 3.2 0.63 10.5 0.0 5.3 5 1 0 5 5 4 1 Tetratricopeptide repeat ST7 PF04184.12 PIK56335.1 - 0.0015 17.1 2.4 0.0015 17.1 2.4 1.5 1 1 0 1 1 1 1 ST7 protein TPR_MalT PF17874.1 PIK56335.1 - 0.0031 16.9 8.8 0.033 13.6 0.7 3.1 1 1 1 2 2 2 1 MalT-like TPR region TPR_10 PF13374.6 PIK56335.1 - 0.0043 16.9 11.8 6.1 6.9 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK56335.1 - 0.013 15.5 5.2 0.69 10.0 0.1 4.3 4 0 0 4 4 4 0 Domain of Unknown Function (DUF3856) PPR PF01535.20 PIK56335.1 - 0.16 12.3 4.3 22 5.6 0.0 4.7 6 0 0 6 6 4 0 PPR repeat MAS20 PF02064.15 PIK56335.1 - 0.18 11.9 0.1 0.18 11.9 0.1 3.6 3 1 0 3 3 2 0 MAS20 protein import receptor RPN7 PF10602.9 PIK56335.1 - 0.19 11.4 19.5 1.2 8.8 0.4 5.7 1 1 5 6 6 6 0 26S proteasome subunit RPN7 TPR_4 PF07721.14 PIK56335.1 - 0.31 11.8 3.1 12 6.9 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat HEPN PF05168.14 PIK56335.1 - 0.77 9.9 15.8 1.8 8.7 1.3 4.8 3 2 2 5 5 5 0 HEPN domain YfdX PF10938.8 PIK56335.1 - 6.7 6.6 16.7 0.31 11.0 1.1 4.2 3 2 0 3 3 3 0 YfdX protein DP PF08781.10 PIK56336.1 - 8e-62 207.2 1.7 1.8e-61 206.0 1.7 1.6 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 PIK56336.1 - 2.2e-26 91.7 0.1 8e-26 89.9 0.0 2.0 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain HTH_40 PF14493.6 PIK56337.1 - 3.7e-21 75.4 0.0 9.3e-21 74.1 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain RQC PF09382.10 PIK56337.1 - 5.8e-19 68.0 0.0 1.3e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 PIK56337.1 - 1.6e-17 63.8 0.0 7.5e-17 61.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK56337.1 - 1.2e-14 54.5 0.0 1.2e-13 51.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase HRDC PF00570.23 PIK56337.1 - 2.7e-14 52.9 0.0 6.1e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 HRDC domain RecQ_Zn_bind PF16124.5 PIK56337.1 - 3.2e-07 30.9 3.7 1.3e-06 29.0 3.4 2.1 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 PIK56337.1 - 8.6e-05 22.6 0.0 0.00078 19.5 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ALO PF04030.14 PIK56338.1 - 4.4e-20 72.6 0.3 8.1e-20 71.7 0.1 1.5 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 PIK56338.1 - 1.4e-06 28.1 0.1 2.2e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DSPc PF00782.20 PIK56339.1 - 8.5e-32 109.8 0.0 1.3e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK56339.1 - 1.3e-06 28.8 0.1 6.3e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain Init_tRNA_PT PF04179.12 PIK56339.1 - 0.015 15.6 0.0 0.035 14.4 0.0 1.6 2 0 0 2 2 2 0 Rit1 DUSP-like domain zf-CCCH PF00642.24 PIK56339.1 - 0.12 12.3 0.5 0.27 11.2 0.1 1.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Y_phosphatase PF00102.27 PIK56339.1 - 0.15 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase UCH PF00443.29 PIK56340.1 - 4.3e-35 121.4 0.1 5.6e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 PIK56340.1 - 2.3e-13 50.2 3.9 5.3e-13 49.1 2.5 2.1 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 PIK56340.1 - 2.8e-05 23.9 0.1 7.8e-05 22.4 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PTEN_C2 PF10409.9 PIK56340.1 - 0.045 13.5 0.1 0.12 12.1 0.1 1.7 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein zf-UBP_var PF17807.1 PIK56340.1 - 0.059 13.1 1.5 0.17 11.7 1.5 1.8 1 0 0 1 1 1 0 Variant UBP zinc finger RRM_1 PF00076.22 PIK56341.1 - 2.2e-13 49.8 0.0 3.5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 PIK56341.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 DbpA RNA binding domain RRM_1 PF00076.22 PIK56342.1 - 7.1e-14 51.4 0.0 1.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPARC_Ca_bdg PF10591.9 PIK56344.1 - 4.3e-21 75.3 3.3 8.6e-21 74.4 3.3 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 PIK56344.1 - 2.8e-07 30.6 5.9 8.6e-07 29.0 5.9 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK56344.1 - 4.9e-05 23.3 8.0 4.9e-05 23.3 8.0 2.1 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 PIK56344.1 - 0.00054 20.4 1.8 0.0012 19.3 1.8 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK56344.1 - 0.0044 16.5 0.7 0.016 14.7 0.7 2.0 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 PIK56344.1 - 0.0065 15.9 3.1 0.0065 15.9 3.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 PIK56344.1 - 0.01 15.7 4.5 0.016 15.1 3.0 2.2 2 0 0 2 2 2 0 EF-hand domain GST_C_3 PF14497.6 PIK56345.1 - 1.9e-17 63.3 0.2 2.3e-17 63.0 0.2 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56345.1 - 2.5e-07 30.8 0.1 4.2e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56345.1 - 5.9e-05 23.0 0.0 8.9e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK56345.1 - 0.0018 18.1 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK56346.1 - 2.7e-21 75.6 0.0 4e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56346.1 - 4.6e-10 39.7 0.1 1e-09 38.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK56346.1 - 1.2e-06 28.7 0.0 2.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56346.1 - 0.00017 21.5 0.0 0.00038 20.4 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK56346.1 - 0.00062 20.1 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK56346.1 - 0.0017 19.1 0.0 0.0036 18.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 PIK56346.1 - 0.025 14.9 0.0 0.047 14.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK56346.1 - 0.039 13.7 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 PIK56346.1 - 0.085 13.4 0.0 0.14 12.8 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56347.1 - 9.7e-12 45.1 0.1 2.4e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK56347.1 - 1.3e-11 44.5 0.0 2.5e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56347.1 - 2e-07 31.1 0.1 6.5e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK56347.1 - 0.00032 21.1 0.0 0.00067 20.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK56347.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 PIK56347.1 - 0.0085 16.8 0.0 0.019 15.7 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 PIK56347.1 - 0.011 16.0 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain 7tm_2 PF00002.24 PIK56349.1 - 3.4e-12 46.2 1.6 5.7e-12 45.4 1.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HrcA PF01628.21 PIK56349.1 - 0.01 15.8 4.2 0.019 14.9 4.2 1.4 1 0 0 1 1 1 0 HrcA protein C terminal domain GPS PF01825.21 PIK56349.1 - 0.028 14.9 0.2 0.067 13.7 0.2 1.6 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif Vta1 PF04652.16 PIK56349.1 - 0.17 11.8 1.2 0.39 10.7 1.2 1.6 1 0 0 1 1 1 0 Vta1 like GST_C_3 PF14497.6 PIK56350.1 - 7.7e-09 35.7 0.0 1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56350.1 - 2.6e-06 27.6 0.0 3.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56350.1 - 0.044 13.8 0.0 0.048 13.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Xpo1 PF08389.12 PIK56350.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Exportin 1-like protein Baculo_11_kDa PF06143.11 PIK56352.1 - 4.6 6.9 7.8 0.54 9.9 2.7 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF4083 PF13314.6 PIK56352.1 - 6.3 6.8 7.2 0.66 10.0 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) GPS PF01825.21 PIK56353.1 - 1.9e-12 47.5 2.7 3.5e-12 46.6 2.7 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK56353.1 - 2.3e-07 30.5 1.1 3e-07 30.1 1.1 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.24 PIK56354.1 - 2.1e-18 66.5 9.8 3.5e-18 65.8 9.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK56354.1 - 6e-15 55.5 4.9 6e-15 55.5 4.9 1.9 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif IgGFc_binding PF17517.2 PIK56355.1 - 4.3e-19 68.9 0.2 4.3e-19 68.9 0.2 2.5 2 1 0 2 2 2 1 IgGFc binding protein DUF765 PF05570.11 PIK56355.1 - 0.051 13.8 1.0 4.5 7.5 0.1 3.0 2 0 0 2 2 2 0 Circovirus protein of unknown function (DUF765) GPS PF01825.21 PIK56356.1 - 2.1e-16 60.1 5.0 4.7e-16 59.0 5.0 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 PIK56357.1 - 4e-29 101.6 14.6 7.2e-29 100.8 14.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK56357.1 - 2e-16 60.2 4.5 4.6e-16 59.1 4.5 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif IgGFc_binding PF17517.2 PIK56357.1 - 1.1e-07 31.5 0.2 1.1e-07 31.5 0.2 2.3 2 1 1 3 3 3 1 IgGFc binding protein 7tm_2 PF00002.24 PIK56358.1 - 7.9e-14 51.5 0.1 1.3e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK56358.1 - 1.3e-09 38.5 2.8 2.8e-09 37.3 2.8 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK56358.1 - 0.013 14.7 0.3 0.02 14.0 0.3 1.2 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor CENP-B_dimeris PF09026.10 PIK56358.1 - 0.036 14.4 8.7 0.13 12.6 7.9 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CooT PF10133.9 PIK56358.1 - 0.11 12.8 0.2 0.23 11.8 0.2 1.5 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT NOA36 PF06524.12 PIK56358.1 - 0.34 10.2 6.2 0.66 9.3 6.2 1.4 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 PIK56358.1 - 3.6 6.6 9.2 6.6 5.8 9.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.12 PIK56358.1 - 6.4 6.1 9.2 10 5.4 0.2 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RVT_1 PF00078.27 PIK56359.1 - 7.3e-13 48.5 0.0 9.9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Longin PF13774.6 PIK56360.1 - 2.5e-11 43.5 0.5 4e-11 42.8 0.5 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 PIK56360.1 - 8.9e-05 22.2 0.8 8.9e-05 22.2 0.8 1.7 2 0 0 2 2 2 1 Synaptobrevin Glyco_hydro_38N PF01074.22 PIK56361.1 - 8.8e-59 199.2 0.8 1.1e-58 198.9 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain AcetylCoA_hydro PF02550.15 PIK56361.1 - 0.17 11.9 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase N-terminal domain Glyco_hydro_38C PF07748.13 PIK56362.1 - 2.9e-45 155.0 0.3 6.7e-45 153.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 PIK56362.1 - 1.8e-20 72.9 0.0 3.8e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38N PF01074.22 PIK56362.1 - 4.5e-18 65.6 0.4 8.7e-18 64.7 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro38C2 PF17677.1 PIK56362.1 - 1.3e-09 38.1 0.0 2.6e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain CLCA PF08434.11 PIK56363.1 - 4.1e-30 105.0 1.0 7.4e-30 104.2 1.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK56363.1 - 1e-13 51.9 0.1 2.4e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK56363.1 - 6.4e-13 49.3 0.0 3.6e-12 46.9 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK56363.1 - 8.5e-10 38.4 0.0 1.5e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK56363.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1194 PF06707.11 PIK56363.1 - 0.0088 15.3 0.2 0.032 13.4 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1194) Meth_synt_2 PF01717.18 PIK56364.1 - 0.14 11.4 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, Catalytic domain CLCA PF08434.11 PIK56365.1 - 9.6e-57 192.3 0.1 1.4e-56 191.8 0.1 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK56365.1 - 4.3e-09 36.9 1.6 0.00075 19.8 0.0 2.8 2 1 1 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 PIK56365.1 - 1.1e-05 26.0 0.3 3.2e-05 24.5 0.3 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK56365.1 - 8.3e-05 22.1 0.0 0.02 14.3 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein DUF3341 PF11821.8 PIK56365.1 - 0.087 12.5 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) GST_C_3 PF14497.6 PIK56366.1 - 3.1e-16 59.4 0.0 4e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56366.1 - 0.00015 21.9 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56366.1 - 0.00024 21.4 0.1 0.0023 18.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK56366.1 - 0.0014 18.6 0.0 0.0021 18.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Xpo1 PF08389.12 PIK56366.1 - 0.0071 16.4 0.0 0.0078 16.3 0.0 1.2 1 0 0 1 1 1 1 Exportin 1-like protein GST_N_2 PF13409.6 PIK56366.1 - 0.0081 16.4 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK56366.1 - 0.01 16.3 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK56366.1 - 0.065 14.0 0.0 0.13 13.0 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_3 PF14497.6 PIK56367.1 - 5e-21 74.8 0.2 6.1e-21 74.5 0.2 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56367.1 - 2.4e-12 46.9 0.1 3.2e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56367.1 - 4.3e-06 26.7 0.0 6.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK56367.1 - 0.036 13.9 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56368.1 - 2.8e-12 46.8 0.0 3.1e-12 46.7 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK56368.1 - 4.8e-06 26.9 0.0 6e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 PIK56368.1 - 0.00015 22.0 0.0 0.00018 21.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_5 PF18485.1 PIK56368.1 - 0.017 15.5 0.0 0.067 13.5 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK56368.1 - 0.051 14.3 0.0 0.062 14.1 0.0 1.3 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_3 PF14497.6 PIK56369.1 - 2.9e-22 78.7 0.1 4.2e-22 78.2 0.1 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56369.1 - 9.9e-11 41.7 0.0 2.6e-10 40.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56369.1 - 1.7e-07 31.2 0.0 4.2e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56369.1 - 3.3e-07 30.5 0.0 8.2e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK56369.1 - 0.00013 21.7 0.1 0.00065 19.4 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK56370.1 - 4.5e-14 52.4 0.0 6.4e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56370.1 - 2.5e-12 47.0 0.0 5.6e-12 45.8 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK56370.1 - 1.7e-06 28.1 0.0 2.5e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK56370.1 - 0.00027 21.3 0.0 0.00085 19.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK56370.1 - 0.00043 20.2 0.0 0.00073 19.5 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 PIK56370.1 - 0.0024 18.6 0.0 0.0048 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain zf-C6H2 PF15801.5 PIK56371.1 - 2.2e-21 75.9 11.2 3.1e-21 75.4 11.2 1.2 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 PIK56371.1 - 0.00022 21.2 6.2 0.00035 20.6 6.2 1.3 1 0 0 1 1 1 1 MYND finger Peptidase_M24 PF00557.24 PIK56372.1 - 4.8e-57 193.0 0.5 5.5e-57 192.8 0.5 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 FolB PF02152.18 PIK56372.1 - 0.051 14.1 0.0 4.3 7.9 0.0 2.5 2 1 0 2 2 2 0 Dihydroneopterin aldolase Abhydrolase_3 PF07859.13 PIK56373.1 - 7.3e-22 78.3 0.0 1.3e-17 64.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK56373.1 - 3e-16 59.4 0.1 7.7e-14 51.4 0.1 2.7 2 1 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 PIK56373.1 - 1.6e-11 44.1 0.1 6.1e-09 35.7 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 PIK56373.1 - 3.6e-08 34.3 0.0 3.2e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK56373.1 - 0.00019 20.8 0.2 0.044 13.1 0.2 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 LIP PF03583.14 PIK56373.1 - 0.0003 20.2 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 2 Secretory lipase Abhydrolase_1 PF00561.20 PIK56373.1 - 0.00059 19.6 0.6 0.92 9.1 0.6 3.0 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 PIK56373.1 - 0.0014 18.4 0.0 0.046 13.5 0.0 2.7 4 0 0 4 4 4 1 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 PIK56373.1 - 0.0024 17.7 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Say1_Mug180 PF10340.9 PIK56373.1 - 0.025 13.4 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase DLH PF01738.18 PIK56373.1 - 0.045 13.3 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF1749 PF08538.10 PIK56373.1 - 0.079 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Maff2 PF12750.7 PIK56373.1 - 0.12 12.3 0.1 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Maff2 family PAF-AH_p_II PF03403.13 PIK56373.1 - 0.14 10.7 0.1 8.2 4.8 0.0 2.2 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II PhzC-PhzF PF02567.16 PIK56374.1 - 2e-56 191.5 0.0 2.9e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Orn_Arg_deC_N PF02784.16 PIK56375.1 - 2.4e-42 145.0 0.0 2.5e-26 92.6 0.0 2.2 1 1 1 2 2 2 2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 PIK56375.1 - 3.5e-12 46.4 0.0 5.9e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain RUN PF02759.19 PIK56376.1 - 5.4e-31 107.4 1.2 9.7e-31 106.5 0.0 2.0 2 1 0 2 2 2 1 RUN domain Lebercilin PF15619.6 PIK56376.1 - 4.2e-06 26.6 14.7 8.5e-06 25.6 14.7 1.5 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease UPF0242 PF06785.11 PIK56376.1 - 2.7e-05 24.4 13.2 6.8e-05 23.0 13.2 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Lipoprotein_7 PF01540.16 PIK56376.1 - 0.00018 21.0 6.7 0.00033 20.1 6.7 1.4 1 0 0 1 1 1 1 Adhesin lipoprotein Filament PF00038.21 PIK56376.1 - 0.0041 16.7 13.6 0.0069 16.0 13.6 1.2 1 0 0 1 1 1 1 Intermediate filament protein SYCE1 PF15233.6 PIK56376.1 - 0.0055 16.8 13.3 0.015 15.3 13.3 1.8 1 0 0 1 1 1 1 Synaptonemal complex central element protein 1 HAP1_N PF04849.13 PIK56376.1 - 0.0066 15.7 12.7 0.015 14.6 12.7 1.6 1 0 0 1 1 1 1 HAP1 N-terminal conserved region GIT_CC PF16559.5 PIK56376.1 - 0.011 15.6 6.9 0.011 15.6 6.9 3.0 4 1 0 4 4 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Trimer_CC PF08954.11 PIK56376.1 - 0.017 14.6 0.4 0.062 12.9 0.4 1.9 1 0 0 1 1 1 0 Trimerisation motif KASH_CCD PF14662.6 PIK56376.1 - 0.02 14.7 19.5 0.049 13.4 19.5 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 PIK56376.1 - 0.025 14.7 14.8 0.07 13.3 14.8 1.8 1 0 0 1 1 1 0 Tropomyosin like BRE1 PF08647.11 PIK56376.1 - 0.029 14.4 17.0 0.068 13.2 17.0 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Cep57_CLD_2 PF14197.6 PIK56376.1 - 0.047 13.8 17.3 0.11 12.6 15.9 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DUF3450 PF11932.8 PIK56376.1 - 0.059 12.7 10.9 0.12 11.7 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 PIK56376.1 - 0.13 12.3 10.5 0.072 13.1 6.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 PIK56376.1 - 0.15 11.0 15.2 0.27 10.1 15.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 PIK56376.1 - 0.48 10.2 13.0 0.34 10.7 2.2 2.7 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 PIK56376.1 - 0.65 10.1 13.2 0.67 10.1 2.2 3.1 1 1 2 3 3 3 0 bZIP transcription factor YabA PF06156.13 PIK56376.1 - 0.9 10.2 16.5 1.2 9.8 13.0 2.9 2 1 1 3 3 3 0 Initiation control protein YabA V_ATPase_I PF01496.19 PIK56376.1 - 1.3 6.9 7.6 1.9 6.3 7.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cortex-I_coil PF09304.10 PIK56376.1 - 1.5 9.1 14.2 4 7.7 14.2 1.7 1 0 0 1 1 1 0 Cortexillin I, coiled coil ZapB PF06005.12 PIK56376.1 - 3.3 8.2 20.8 21 5.7 20.8 2.3 1 1 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.12 PIK56376.1 - 5.7 7.4 17.3 35 4.9 17.3 2.3 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TMPIT PF07851.13 PIK56376.1 - 6 6.0 8.9 9.5 5.4 8.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Collagen PF01391.18 PIK56377.1 - 1.2e-14 53.8 50.3 3.6e-09 36.2 23.9 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Pex24p PF06398.11 PIK56377.1 - 0.23 10.4 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Collagen PF01391.18 PIK56378.1 - 2.4e-12 46.4 30.2 3.4e-06 26.7 12.7 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) AATF-Che1 PF13339.6 PIK56378.1 - 0.12 13.0 0.5 0.19 12.4 0.5 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor RT_RNaseH PF17917.1 PIK56379.1 - 1.5e-34 118.4 0.1 3.8e-34 117.1 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK56379.1 - 3.4e-33 113.7 0.0 1.1e-32 112.0 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56379.1 - 1.9e-29 102.8 0.1 3.1e-29 102.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) N-glycanase_N PF09112.10 PIK56379.1 - 0.038 13.8 0.0 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 Peptide-N-glycosidase F, N terminal HSBP1 PF06825.12 PIK56379.1 - 0.16 11.9 0.8 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Integrase_H2C2 PF17921.1 PIK56380.1 - 3.6e-21 75.0 1.4 8.8e-21 73.8 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56380.1 - 1.7e-19 70.2 0.0 3.6e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK56380.1 - 0.0001 22.4 0.7 0.00054 20.1 0.7 2.3 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK56380.1 - 0.0024 17.6 0.3 0.012 15.3 0.0 2.2 2 1 0 2 2 2 1 Integrase core domain Phage_cap_E PF03864.15 PIK56380.1 - 0.081 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein E DUF3127 PF11325.8 PIK56380.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) FCH PF00611.23 PIK56381.1 - 4.4e-14 52.5 0.3 4.4e-14 52.5 0.3 2.8 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Lge1 PF11488.8 PIK56381.1 - 0.051 13.8 0.3 1 9.6 0.0 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 AAA_22 PF13401.6 PIK56381.1 - 0.12 12.7 1.0 0.2 11.9 0.1 1.8 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 PIK56381.1 - 3.4 6.6 6.4 0.48 9.4 1.9 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB XYPPX PF02162.17 PIK56382.1 - 7.1e-05 22.5 24.3 7.1e-05 22.5 24.3 7.4 3 2 1 4 4 4 2 XYPPX repeat (two copies) TFIIA_gamma_C PF02751.14 PIK56383.1 - 3.3e-18 65.6 2.7 4.5e-18 65.1 2.7 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 PIK56383.1 - 5.6e-06 26.3 0.1 8.6e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain UPF0524 PF15823.5 PIK56384.1 - 0.98 8.8 7.9 1.2 8.4 7.9 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 CENP-B_dimeris PF09026.10 PIK56384.1 - 1.5 9.3 21.0 0.34 11.3 11.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SGT1 PF07093.11 PIK56384.1 - 3.7 5.9 12.8 0.12 10.8 7.1 1.4 2 0 0 2 2 2 0 SGT1 protein PI3K_1B_p101 PF10486.9 PIK56384.1 - 6.4 4.4 6.9 7.1 4.3 6.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 PIK56384.1 - 8.2 4.6 14.3 9.5 4.4 14.3 1.1 1 0 0 1 1 1 0 CDC45-like protein AAA PF00004.29 PIK56385.1 - 3.5e-39 134.3 0.0 6.3e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 PIK56385.1 - 2.1e-12 46.8 0.1 2.6e-11 43.4 0.1 2.8 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 PIK56385.1 - 2.7e-06 27.1 0.0 4e-05 23.3 0.0 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 PIK56385.1 - 1.6e-05 24.9 0.0 6.9e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK56385.1 - 2.3e-05 24.9 0.0 0.00025 21.5 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 PIK56385.1 - 2.4e-05 23.7 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 PIK56385.1 - 2.9e-05 23.8 0.0 8.7e-05 22.3 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 PIK56385.1 - 5.6e-05 23.4 0.1 0.093 13.0 0.0 2.8 1 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 PIK56385.1 - 6.7e-05 23.1 0.0 0.00019 21.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 PIK56385.1 - 0.00018 21.4 0.0 0.59 10.0 0.0 2.5 1 1 1 2 2 2 2 NACHT domain AAA_18 PF13238.6 PIK56385.1 - 0.00022 21.7 0.0 0.0042 17.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK56385.1 - 0.00084 19.7 0.0 0.0049 17.2 0.0 2.3 2 1 0 2 2 2 1 RNA helicase ATPase PF06745.13 PIK56385.1 - 0.0009 18.7 0.5 1.5 8.1 0.0 2.8 2 1 0 3 3 3 2 KaiC AAA_24 PF13479.6 PIK56385.1 - 0.0013 18.5 0.0 0.0027 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 PIK56385.1 - 0.0034 16.6 0.0 0.0058 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 PIK56385.1 - 0.0058 16.7 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 PIK56385.1 - 0.0063 15.9 0.0 0.074 12.4 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 PIK56385.1 - 0.011 15.5 0.0 0.029 14.1 0.0 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 PIK56385.1 - 0.014 14.9 0.0 0.092 12.3 0.0 2.4 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_17 PF13207.6 PIK56385.1 - 0.017 15.6 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 PIK56385.1 - 0.018 14.9 0.0 0.069 13.0 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 PIK56385.1 - 0.023 14.8 0.0 0.055 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 PIK56385.1 - 0.027 13.6 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Sigma54_activat PF00158.26 PIK56385.1 - 0.033 13.9 0.0 0.94 9.2 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 PIK56385.1 - 0.064 13.2 0.0 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 NTPase TniB PF05621.11 PIK56385.1 - 0.075 12.4 0.0 3.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein KAP_NTPase PF07693.14 PIK56385.1 - 0.085 12.1 0.0 3.8 6.7 0.1 2.3 1 1 1 2 2 2 0 KAP family P-loop domain AAA_25 PF13481.6 PIK56385.1 - 0.091 12.3 0.0 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 PIK56385.1 - 0.1 12.5 0.0 3 7.7 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 PIK56385.1 - 0.11 11.5 0.0 0.82 8.7 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 PIK56385.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RVT_1 PF00078.27 PIK56386.1 - 1.2e-07 31.4 0.2 2.1e-07 30.7 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AbrB_C PF18277.1 PIK56387.1 - 0.22 11.2 0.0 0.41 10.3 0.0 1.4 1 0 0 1 1 1 0 AbrB C-terminal domain TSP_1 PF00090.19 PIK56388.1 - 1.1e-16 60.7 120.4 6.5e-08 32.7 5.5 13.3 12 3 0 12 12 12 9 Thrombospondin type 1 domain TSP_1 PF00090.19 PIK56389.1 - 5e-09 36.2 24.9 1e-07 32.0 8.0 8.0 8 2 0 8 8 8 5 Thrombospondin type 1 domain LRR_8 PF13855.6 PIK56390.1 - 1.8e-41 139.7 91.4 4.1e-12 45.7 11.1 6.9 4 2 4 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 PIK56390.1 - 1.5e-13 50.8 22.7 4.4e-06 26.7 1.5 4.4 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56390.1 - 5.1e-13 49.0 56.2 7.5e-06 26.2 6.2 7.7 3 2 5 8 8 8 5 Leucine Rich repeats (2 copies) LRRNT PF01462.18 PIK56390.1 - 0.00087 18.9 0.8 0.0048 16.5 0.2 2.8 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain Ephrin_rec_like PF07699.13 PIK56390.1 - 0.0015 18.2 29.6 0.018 14.8 3.4 4.9 3 1 1 4 4 4 3 Putative ephrin-receptor like LRR_9 PF14580.6 PIK56390.1 - 0.0016 18.0 23.9 0.27 10.7 3.1 5.3 2 1 4 6 6 6 4 Leucine-rich repeat DUF5362 PF17319.2 PIK56390.1 - 1.9 8.3 4.3 0.29 11.0 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5362) LRR_1 PF00560.33 PIK56390.1 - 3.2 8.7 38.9 4.6 8.2 0.7 10.0 9 1 0 9 9 9 0 Leucine Rich Repeat UCH PF00443.29 PIK56391.1 - 9.4e-69 231.8 0.9 9.4e-69 231.8 0.9 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 PIK56391.1 - 1.6e-21 76.6 3.6 4.7e-21 75.1 3.6 1.9 1 0 0 1 1 1 1 USP8 dimerisation domain UCH_1 PF13423.6 PIK56391.1 - 1.1e-20 74.5 0.9 1.1e-20 74.5 0.9 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase WW PF00397.26 PIK56391.1 - 8.1e-11 41.8 1.8 8.1e-11 41.8 1.8 1.9 2 0 0 2 2 2 1 WW domain Rhodanese PF00581.20 PIK56391.1 - 0.0015 19.1 0.3 0.0061 17.1 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain Allexi_40kDa PF05549.11 PIK56391.1 - 5.5 6.4 7.1 12 5.3 7.1 1.5 1 0 0 1 1 1 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.6 PIK56391.1 - 7.2 7.1 17.6 16 6.0 0.0 3.5 3 0 0 3 3 3 0 Snapin/Pallidin TMEM247 PF15444.6 PIK56391.1 - 8.4 6.4 8.9 24 4.9 8.9 1.9 1 0 0 1 1 1 0 Transmembrane protein 247 SfsA PF03749.13 PIK56392.1 - 0.062 13.2 0.0 4.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Sugar fermentation stimulation protein RE domain FliS PF02561.14 PIK56392.1 - 0.11 12.7 0.7 7.1 6.9 0.2 2.6 2 0 0 2 2 2 0 Flagellar protein FliS Peptidase_S64 PF08192.11 PIK56392.1 - 1.4 7.3 5.5 3.8 5.9 5.5 1.5 1 1 0 1 1 1 0 Peptidase family S64 KH_1 PF00013.29 PIK56393.1 - 3e-35 119.9 3.7 1.2e-17 63.5 0.6 2.4 2 0 0 2 2 2 2 KH domain TUDOR PF00567.24 PIK56393.1 - 3.7e-29 101.2 0.0 7.1e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Tudor domain KH_2 PF07650.17 PIK56393.1 - 4.8e-07 29.5 5.8 0.0012 18.7 0.7 2.5 1 1 1 2 2 2 2 KH domain KH_4 PF13083.6 PIK56393.1 - 0.0001 22.1 2.3 0.0099 15.7 0.1 3.0 2 1 0 2 2 2 2 KH domain KH_5 PF13184.6 PIK56393.1 - 0.00045 20.2 0.8 0.12 12.5 0.1 2.5 2 0 0 2 2 2 2 NusA-like KH domain SKG6 PF08693.10 PIK56393.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EVC2_like PF12297.8 PIK56394.1 - 0.0035 16.1 1.6 1.4 7.5 1.4 2.2 2 0 0 2 2 2 2 Ellis van Creveld protein 2 like protein GAS PF13851.6 PIK56394.1 - 0.039 13.3 5.2 0.34 10.2 1.8 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FliJ PF02050.16 PIK56394.1 - 0.1 12.8 4.6 0.22 11.7 1.2 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein APP_E2 PF12925.7 PIK56394.1 - 0.33 10.6 10.0 0.66 9.7 8.7 1.9 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein DUF4201 PF13870.6 PIK56394.1 - 1.5 8.5 6.3 4.1 7.1 6.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) LRR_8 PF13855.6 PIK56395.1 - 3.8e-71 234.8 98.6 4.6e-16 58.3 5.9 7.8 2 1 9 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 PIK56395.1 - 5.2e-27 93.5 45.5 3.8e-06 27.1 3.5 8.8 8 1 1 9 9 9 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK56395.1 - 9.1e-25 87.1 5.1 7.5e-13 48.6 0.1 3.3 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK56395.1 - 8.7e-09 35.1 25.6 0.00049 19.6 1.0 4.7 1 1 3 4 4 4 4 Leucine-rich repeat FNIP PF05725.12 PIK56395.1 - 0.0032 17.6 1.1 4.5 7.5 1.1 4.2 3 1 0 3 3 3 1 FNIP Repeat LRR_1 PF00560.33 PIK56395.1 - 0.017 15.6 39.4 7.9 7.5 0.1 10.1 10 2 0 10 10 10 0 Leucine Rich Repeat Ephrin_rec_like PF07699.13 PIK56396.1 - 3.6e-06 26.7 18.3 0.0017 18.1 2.7 3.3 1 1 1 2 2 2 2 Putative ephrin-receptor like Sp38 PF07354.12 PIK56396.1 - 0.018 14.5 0.5 0.018 14.5 0.5 2.1 2 1 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) TNFR_c6 PF00020.18 PIK56396.1 - 0.12 12.8 15.9 0.34 11.3 0.1 3.9 1 1 3 4 4 4 0 TNFR/NGFR cysteine-rich region FTH PF01827.27 PIK56396.1 - 0.26 11.1 0.0 0.33 10.7 0.0 1.1 1 0 0 1 1 1 0 FTH domain Chordopox_A13L PF05961.11 PIK56397.1 - 0.061 13.6 3.4 15 5.9 0.0 3.8 3 0 0 3 3 3 0 Chordopoxvirus A13L protein TRP PF06011.12 PIK56397.1 - 0.069 11.9 8.7 0.024 13.4 2.5 2.0 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel DUF2681 PF10883.8 PIK56397.1 - 0.22 12.0 0.0 0.57 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Syndecan PF01034.20 PIK56397.1 - 0.33 10.9 0.0 0.33 10.9 0.0 3.4 4 0 0 4 4 4 0 Syndecan domain SecG PF03840.14 PIK56397.1 - 0.36 11.0 0.0 0.36 11.0 0.0 3.4 4 0 0 4 4 4 0 Preprotein translocase SecG subunit Laminin_EGF PF00053.24 PIK56397.1 - 7.4 6.8 8.1 15 5.8 8.1 1.5 1 0 0 1 1 1 0 Laminin EGF domain Filament PF00038.21 PIK56398.1 - 0.0015 18.2 2.8 0.0017 18.0 2.8 1.1 1 0 0 1 1 1 1 Intermediate filament protein YabA PF06156.13 PIK56398.1 - 0.11 13.1 3.5 0.65 10.7 0.4 2.2 1 1 1 2 2 2 0 Initiation control protein YabA KASH_CCD PF14662.6 PIK56398.1 - 0.19 11.5 11.5 0.3 10.9 11.5 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 PIK56398.1 - 0.7 10.2 14.2 1.3 9.3 0.2 3.5 2 1 1 3 3 3 0 Homeobox associated leucine zipper FlxA PF14282.6 PIK56399.1 - 0.012 15.6 1.0 0.012 15.6 1.0 2.4 3 0 0 3 3 3 0 FlxA-like protein Tup_N PF08581.10 PIK56399.1 - 0.03 14.6 2.1 0.046 14.0 1.0 1.9 2 0 0 2 2 2 0 Tup N-terminal Pheromone PF08015.11 PIK56399.1 - 2.3 9.3 4.8 8.2 7.6 0.1 3.0 3 0 0 3 3 3 0 Fungal mating-type pheromone SAM_2 PF07647.17 PIK56400.1 - 4.1e-23 81.3 2.1 5.6e-09 36.0 0.0 3.3 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK56400.1 - 1.3e-22 80.0 1.6 2.5e-11 43.8 0.1 3.2 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) LRR_4 PF12799.7 PIK56401.1 - 3e-18 65.6 44.7 0.00013 22.3 4.3 7.0 5 1 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK56401.1 - 5.4e-18 64.5 36.1 1.3e-07 31.3 2.6 6.5 3 2 3 6 6 6 6 Leucine rich repeat IQ PF00612.27 PIK56401.1 - 1.2e-09 37.0 1.3 8.9e-06 25.1 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif LRR_9 PF14580.6 PIK56401.1 - 1.5e-06 27.8 8.1 0.00019 21.0 0.9 3.7 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 PIK56401.1 - 0.011 15.7 23.8 2.1 8.6 0.2 8.1 8 1 1 9 9 9 0 Leucine Rich repeat LRR_1 PF00560.33 PIK56401.1 - 0.027 15.0 36.4 1.7 9.5 0.1 8.7 8 1 0 8 8 8 0 Leucine Rich Repeat Topo_C_assoc PF14370.6 PIK56402.1 - 3.3e-09 36.6 11.5 3.5 7.6 0.1 9.0 1 1 10 11 11 11 5 C-terminal topoisomerase domain NCE101 PF11654.8 PIK56402.1 - 0.00062 19.4 15.9 7.3 6.4 0.0 8.2 6 2 4 10 10 10 3 Non-classical export protein 1 EphA2_TM PF14575.6 PIK56402.1 - 0.048 14.5 5.7 27 5.7 0.9 4.9 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain zf-Paramyx-P PF13008.7 PIK56402.1 - 0.12 11.9 5.0 4.4 6.9 0.1 4.8 3 3 3 7 7 7 0 Zinc-binding domain of Paramyxoviridae V protein Ig_3 PF13927.6 PIK56403.1 - 1.1e-20 74.0 1.2 1.8e-06 28.5 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK56403.1 - 1.5e-17 63.4 0.1 3.4e-09 36.6 0.0 4.1 5 0 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.25 PIK56403.1 - 3.3e-17 62.4 5.3 2.3e-06 27.7 0.0 4.8 4 1 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK56403.1 - 4.7e-13 49.3 3.1 5.3e-06 26.7 1.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK56403.1 - 1.1e-11 44.8 0.0 4.2e-09 36.5 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK56403.1 - 1.6e-08 34.5 4.1 9.1e-08 32.1 0.3 3.5 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Rax2 PF12768.7 PIK56403.1 - 0.0044 16.5 0.1 0.0078 15.7 0.1 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF4577 PF15145.6 PIK56403.1 - 0.048 13.7 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) TMEM154 PF15102.6 PIK56403.1 - 0.28 11.1 6.5 0.72 9.8 6.5 1.6 1 1 0 1 1 1 0 TMEM154 protein family LIM PF00412.22 PIK56404.1 - 3.4e-14 52.8 12.5 3e-11 43.4 6.6 2.2 2 0 0 2 2 2 2 LIM domain zinc-ribbons_6 PF07191.12 PIK56404.1 - 0.52 10.3 9.9 1.9 8.6 5.5 2.7 2 1 0 2 2 2 0 zinc-ribbons zf-Di19 PF05605.12 PIK56404.1 - 1.8 8.9 7.7 0.24 11.7 2.2 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DnaJ_CXXCXGXG PF00684.19 PIK56404.1 - 2.2 8.7 12.2 2.7 8.4 3.5 2.6 2 1 0 2 2 2 0 DnaJ central domain Anti-TRAP PF15777.5 PIK56404.1 - 5.5 7.0 10.9 3.8 7.6 0.2 3.0 2 1 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Y_phosphatase PF00102.27 PIK56405.1 - 1.6e-05 24.6 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PRIMA1 PF16101.5 PIK56405.1 - 0.014 15.4 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Orthoreo_P10 PF07204.11 PIK56405.1 - 0.039 13.9 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 DUF4059 PF13268.6 PIK56405.1 - 0.043 14.2 0.0 0.072 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) MAP17 PF15807.5 PIK56405.1 - 0.052 13.8 0.0 0.086 13.1 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 WBP-1 PF11669.8 PIK56405.1 - 0.061 14.0 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 Rhabdo_glycop PF00974.18 PIK56405.1 - 0.086 11.3 0.2 0.15 10.5 0.2 1.3 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Adeno_E3_CR2 PF02439.15 PIK56405.1 - 0.69 9.7 10.5 1.1 9.0 10.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Y_phosphatase PF00102.27 PIK56406.1 - 4.6e-17 62.4 0.4 1.7e-15 57.3 0.1 2.0 1 1 1 2 2 2 2 Protein-tyrosine phosphatase TAFII28 PF04719.14 PIK56407.1 - 9.7e-12 44.8 0.1 1.9e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CaM_binding PF07839.11 PIK56407.1 - 0.0045 17.7 2.6 0.0071 17.1 2.4 1.5 1 1 0 1 1 1 1 Plant calmodulin-binding domain Med13_C PF06333.12 PIK56407.1 - 0.078 12.2 4.5 0.092 12.0 4.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain UQ_con PF00179.26 PIK56408.1 - 7.1e-18 64.6 0.0 1.2e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EF-hand_1 PF00036.32 PIK56409.1 - 1.8e-11 42.8 13.2 0.0031 16.9 1.4 4.6 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 PIK56409.1 - 4.5e-10 38.6 7.4 0.11 12.5 0.0 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 PIK56409.1 - 9.6e-10 38.8 8.8 2.2e-07 31.2 1.8 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK56409.1 - 1.3e-06 27.6 15.0 0.0013 18.1 1.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK56409.1 - 0.0024 17.7 10.9 0.13 12.1 0.6 4.1 4 0 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK56409.1 - 0.051 13.9 1.1 6.1 7.2 0.1 2.4 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Importin_rep PF18773.1 PIK56409.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Importin 13 repeat Dockerin_1 PF00404.18 PIK56409.1 - 0.14 12.4 2.7 28 5.0 0.4 3.7 3 1 0 3 3 3 0 Dockerin type I domain EF-hand_4 PF12763.7 PIK56409.1 - 0.27 11.2 4.9 2.2 8.3 0.1 2.8 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 PIK56410.1 - 1.5e-07 31.8 5.3 9.6e-06 26.0 2.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK56410.1 - 5.8e-06 25.8 0.6 0.00041 20.1 0.1 2.7 1 1 1 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 PIK56410.1 - 0.00023 20.5 0.1 0.0008 18.8 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 PIK56410.1 - 0.0014 18.1 0.0 0.0014 18.1 0.0 2.7 3 1 0 3 3 3 1 EF hand EFhand_Ca_insen PF08726.10 PIK56410.1 - 0.014 15.5 1.5 0.075 13.1 0.2 2.2 2 0 0 2 2 2 0 Ca2+ insensitive EF hand EF-hand_8 PF13833.6 PIK56410.1 - 0.02 14.7 0.4 0.16 11.8 0.1 2.3 2 1 0 2 2 2 0 EF-hand domain pair PSS PF03034.15 PIK56411.1 - 1.1e-103 346.7 14.4 1.1e-103 346.7 14.4 1.6 2 0 0 2 2 2 1 Phosphatidyl serine synthase DUF3382 PF11862.8 PIK56411.1 - 0.0045 17.2 0.5 0.23 11.8 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3382) DUF5452 PF17533.2 PIK56411.1 - 0.0065 16.6 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5452) TctB PF07331.11 PIK56411.1 - 0.01 16.1 0.5 0.01 16.1 0.5 2.3 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family COQ9 PF08511.11 PIK56411.1 - 0.026 14.3 0.0 1.1 9.1 0.0 2.7 2 0 0 2 2 2 0 COQ9 Thymidylat_synt PF00303.19 PIK56412.1 - 1.4e-99 332.6 0.0 1.7e-99 332.3 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase RVT_1 PF00078.27 PIK56413.1 - 0.00032 20.3 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK56413.1 - 0.031 14.3 0.2 0.53 10.3 0.0 2.5 3 0 0 3 3 3 0 RNase H-like domain found in reverse transcriptase Thymidylat_synt PF00303.19 PIK56414.1 - 4.3e-12 45.7 0.0 5.2e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase Ku_N PF03731.15 PIK56415.1 - 7.6e-49 166.4 0.9 2.3e-48 164.9 0.9 1.7 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 PIK56415.1 - 3.7e-35 121.5 0.3 3.5e-22 79.1 0.0 2.3 1 1 1 2 2 2 2 Ku70/Ku80 beta-barrel domain SAP PF02037.27 PIK56416.1 - 4.4e-09 35.9 0.0 6.4e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 SAP domain Rho_N PF07498.12 PIK56416.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain Luteo_P1-P2 PF08467.10 PIK56416.1 - 0.071 12.4 0.1 0.087 12.1 0.1 1.0 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase TPR_2 PF07719.17 PIK56417.1 - 1e-14 53.3 1.4 4.8e-06 26.3 0.0 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56417.1 - 3.7e-14 51.9 1.9 7.9e-06 25.5 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat FKBP_C PF00254.28 PIK56417.1 - 2.4e-10 40.6 0.2 6.1e-10 39.3 0.2 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_8 PF13181.6 PIK56417.1 - 3.1e-09 36.3 4.6 1.5e-05 24.9 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56417.1 - 3.7e-07 29.7 0.3 0.02 14.6 0.0 3.4 2 1 1 3 3 3 3 TPR repeat TPR_6 PF13174.6 PIK56417.1 - 1.4e-06 28.6 0.9 0.022 15.3 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK56417.1 - 3.8e-05 23.7 1.6 0.23 11.5 0.3 3.0 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 PIK56417.1 - 0.00033 21.1 0.4 0.17 12.4 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56417.1 - 0.002 18.0 0.0 0.36 11.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56417.1 - 0.0029 17.9 0.4 0.1 12.9 0.5 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK56417.1 - 0.0072 16.5 0.0 0.03 14.5 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56417.1 - 0.029 15.2 1.1 71 4.6 0.1 3.7 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56417.1 - 0.37 11.5 6.4 15 6.3 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat FAM178 PF14816.6 PIK56417.1 - 1.2 8.0 5.1 2 7.3 5.1 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 FKBP_C PF00254.28 PIK56418.1 - 5e-15 55.6 0.0 1e-14 54.6 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ldl_recept_b PF00058.17 PIK56419.1 - 1.1e-79 262.6 24.9 1.1e-10 41.7 0.0 10.6 10 0 0 10 10 10 9 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK56419.1 - 9.5e-18 64.2 32.4 1.9e-12 47.2 9.6 3.3 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 PIK56419.1 - 2.9e-12 46.4 0.0 1.6e-05 24.3 0.0 3.2 2 1 1 3 3 3 3 Domain of unknown function (DUF5050) SGL PF08450.12 PIK56419.1 - 1.4e-11 44.5 10.2 0.073 12.6 0.0 6.4 4 1 1 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 PIK56419.1 - 0.00049 20.3 22.0 0.0067 16.7 8.3 3.0 2 0 0 2 2 2 2 EGF-like domain Arylesterase PF01731.20 PIK56419.1 - 0.00085 19.5 0.0 4.2 7.6 0.0 4.3 4 0 0 4 4 4 1 Arylesterase cEGF PF12662.7 PIK56419.1 - 3.9 7.5 5.9 0.44 10.5 0.8 2.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Ldl_recept_b PF00058.17 PIK56420.1 - 1.4e-84 278.4 34.0 1.4e-15 57.5 0.0 9.8 10 0 0 10 10 10 9 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 PIK56420.1 - 3.9e-81 266.9 152.0 2.3e-13 50.1 10.2 9.5 9 1 1 10 10 10 8 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 PIK56420.1 - 4.7e-18 65.2 43.3 1.4e-09 38.0 7.8 6.5 6 0 0 6 6 6 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK56420.1 - 1.7e-10 40.9 2.9 0.047 13.3 0.0 5.7 4 2 1 5 5 5 4 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 PIK56420.1 - 1.7e-10 40.6 30.1 6.5e-07 29.2 0.1 5.3 5 0 0 5 5 5 3 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK56420.1 - 1.5e-06 28.2 6.7 1.5e-06 28.2 6.7 10.2 6 2 4 11 11 11 3 Calcium-binding EGF domain Arylesterase PF01731.20 PIK56420.1 - 0.029 14.6 0.0 11 6.3 0.0 3.7 4 0 0 4 4 4 0 Arylesterase NHL PF01436.21 PIK56420.1 - 0.044 13.8 0.0 14 5.9 0.0 4.1 4 0 0 4 4 4 0 NHL repeat SL4P PF17618.2 PIK56420.1 - 6.3 6.9 6.5 86 3.3 0.1 4.4 6 0 0 6 6 6 0 Uncharacterized Strongylid L4 protein WD40 PF00400.32 PIK56422.1 - 1.5e-12 47.8 0.2 9.4e-08 32.6 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56422.1 - 7.8e-06 26.1 0.0 5.1e-05 23.5 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK56422.1 - 0.1 12.5 0.0 2.8 7.8 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A LAP1C PF05609.12 PIK56423.1 - 0.014 14.5 9.6 0.019 14.1 9.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 PIK56423.1 - 0.83 6.7 10.6 1 6.4 10.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PNISR PF15996.5 PIK56423.1 - 2.8 8.2 10.3 5.6 7.2 10.2 1.5 1 1 0 1 1 1 0 Arginine/serine-rich protein PNISR SRCR PF00530.18 PIK56424.1 - 0 1239.9 82.5 5.9e-28 97.3 0.2 20.8 20 1 1 21 21 21 20 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK56424.1 - 1.4e-67 224.3 56.9 0.00036 21.0 0.1 20.2 20 0 0 20 20 20 18 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK56424.1 - 3.9e-29 101.4 43.8 1.2 9.7 0.0 19.8 19 1 0 19 19 19 10 Hepsin, SRCR domain YecR PF13992.6 PIK56424.1 - 1.6e-16 60.3 14.1 2.5 8.5 0.1 15.4 17 0 0 17 17 17 4 YecR-like lipoprotein SapB_2 PF03489.17 PIK56424.1 - 0.037 14.1 20.2 31 4.8 0.0 12.3 18 0 0 18 18 18 0 Saposin-like type B, region 2 SRCR PF00530.18 PIK56425.1 - 8.2e-33 112.9 0.5 5.1e-21 75.1 0.0 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK56425.1 - 3.2e-05 24.4 0.0 5.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK56425.1 - 0.00081 19.9 0.0 0.0015 19.0 0.0 1.4 1 0 0 1 1 1 1 Hepsin, SRCR domain Defensin_beta PF00711.19 PIK56425.1 - 0.034 14.2 3.0 1 9.4 0.1 2.6 2 0 0 2 2 2 0 Beta defensin Defensin_beta_2 PF13841.6 PIK56425.1 - 0.44 11.1 2.6 1.7 9.2 0.3 2.5 2 0 0 2 2 2 0 Beta defensin Frag1 PF10277.9 PIK56426.1 - 1.5e-35 122.8 10.0 1.7e-35 122.6 10.0 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family EII-Sor PF03609.14 PIK56426.1 - 0.38 10.1 9.4 0.69 9.3 9.5 1.5 1 1 1 2 2 2 0 PTS system sorbose-specific iic component Tudor_4 PF18358.1 PIK56427.1 - 4.8e-14 51.7 0.1 9.7e-14 50.7 0.1 1.5 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain OmpH PF03938.14 PIK56427.1 - 0.99 9.7 8.1 0.17 12.2 3.7 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF812 PF05667.11 PIK56427.1 - 1.4 7.7 12.6 0.56 9.0 4.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) YabA PF06156.13 PIK56427.1 - 5.8 7.6 7.9 7.9 7.2 6.2 2.2 1 1 0 1 1 1 0 Initiation control protein YabA SET PF00856.28 PIK56428.1 - 1.1e-26 94.2 3.2 8.9e-26 91.3 0.7 3.0 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 PIK56428.1 - 7.9e-17 61.9 9.3 7.9e-17 61.9 9.3 1.9 2 0 0 2 2 2 1 Pre-SET motif MBD PF01429.19 PIK56428.1 - 3.4e-10 39.5 0.0 8.4e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-RING_2 PF13639.6 PIK56429.1 - 4.6e-13 49.3 6.5 8.8e-13 48.4 6.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 PIK56429.1 - 8.2e-09 35.1 1.5 8.2e-09 35.1 1.5 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK56429.1 - 1.7e-08 34.1 5.6 3.2e-08 33.3 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK56429.1 - 6.6e-08 32.7 6.9 1.8e-07 31.3 6.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK56429.1 - 1.7e-06 27.8 6.4 3.5e-06 26.8 6.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK56429.1 - 2.2e-06 27.5 5.2 4e-06 26.7 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK56429.1 - 3.9e-05 23.4 4.1 7.2e-05 22.6 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK56429.1 - 4.2e-05 23.5 0.5 4.2e-05 23.5 0.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK56429.1 - 0.00063 19.5 3.4 0.0014 18.4 3.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 PIK56429.1 - 0.0042 16.7 3.7 0.0088 15.6 3.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 PIK56429.1 - 0.0059 16.6 4.3 0.02 14.9 4.3 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 PIK56429.1 - 0.0096 16.0 3.6 0.027 14.6 3.6 1.8 1 1 0 1 1 1 1 RING-variant domain zinc_ribbon_16 PF17034.5 PIK56429.1 - 0.056 13.7 0.3 0.12 12.6 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 PIK56429.1 - 0.13 12.3 2.0 0.33 11.0 2.0 1.7 1 0 0 1 1 1 0 Zinc-finger Zf_RING PF16744.5 PIK56429.1 - 0.52 10.5 4.0 1.4 9.1 3.9 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 PIK56429.1 - 2.4 8.4 8.0 5.6 7.2 5.8 2.8 2 1 0 2 2 2 0 FANCL C-terminal domain DUF3660 PF12398.8 PIK56430.1 - 0.13 12.3 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Receptor serine/threonine kinase Fibrinogen_C PF00147.18 PIK56431.1 - 3.5e-22 79.3 0.6 5.4e-22 78.7 0.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PAN_1 PF00024.26 PIK56431.1 - 4.9e-07 29.6 0.5 3.9e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 PAN domain Fibrinogen_C PF00147.18 PIK56432.1 - 1.6e-23 83.6 7.6 1.9e-23 83.4 7.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PI3_PI4_kinase PF00454.27 PIK56433.1 - 8.1e-53 179.8 0.1 3.4e-52 177.8 0.1 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 PIK56433.1 - 1.2e-37 129.1 0.9 2.6e-37 128.0 0.9 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 PIK56433.1 - 3.5e-18 65.9 0.0 9.2e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 PIK56433.1 - 2e-10 40.8 0.1 5.2e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PX PF00787.24 PIK56433.1 - 4.4e-09 36.3 0.2 2.3e-08 34.0 0.2 2.3 1 0 0 1 1 1 1 PX domain DUF4135 PF13575.6 PIK56433.1 - 0.00041 19.8 0.0 0.0012 18.3 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4135) GH3 PF03321.13 PIK56434.1 - 2.6e-13 49.7 0.1 2.9e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter HicA_toxin PF07927.12 PIK56434.1 - 0.2 11.7 0.4 2.2 8.4 0.0 2.2 2 0 0 2 2 2 0 HicA toxin of bacterial toxin-antitoxin, RVT_1 PF00078.27 PIK56435.1 - 9.4e-08 31.8 0.0 2.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK56435.1 - 2.3e-05 24.6 0.0 0.00019 21.6 0.0 2.3 2 0 0 2 2 2 1 GIY-YIG catalytic domain GH3 PF03321.13 PIK56436.1 - 2.2e-41 142.4 0.0 3.8e-40 138.2 0.0 2.0 1 1 0 1 1 1 1 GH3 auxin-responsive promoter GH3 PF03321.13 PIK56437.1 - 4.7e-23 81.8 0.0 6e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Ost5 PF05251.12 PIK56437.1 - 0.11 12.8 9.8 0.21 11.9 9.8 1.6 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Ribosomal_S9 PF00380.19 PIK56438.1 - 5.5e-20 72.1 0.0 6.7e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Nicastrin PF05450.15 PIK56438.1 - 0.0021 17.6 0.0 0.87 9.0 0.0 2.1 2 0 0 2 2 2 2 Nicastrin Homeodomain PF00046.29 PIK56439.1 - 4e-15 55.4 0.5 7.5e-15 54.5 0.5 1.4 1 0 0 1 1 1 1 Homeodomain FmiP_Thoc5 PF09766.9 PIK56439.1 - 0.0065 15.8 2.1 0.0078 15.5 2.1 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 CDC45 PF02724.14 PIK56439.1 - 0.43 8.8 11.6 0.47 8.7 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 PIK56439.1 - 0.94 9.1 7.6 1.2 8.8 7.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 PIK56439.1 - 1.2 7.8 5.6 1.2 7.8 5.6 1.1 1 0 0 1 1 1 0 Presenilin Homeodomain PF00046.29 PIK56440.1 - 2.8e-14 52.7 0.5 4.8e-14 51.9 0.5 1.3 1 0 0 1 1 1 1 Homeodomain DUF5558 PF17713.1 PIK56440.1 - 1.4 9.3 3.3 12 6.3 0.2 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5558) PDZ PF00595.24 PIK56441.1 - 7.1e-57 189.7 15.4 2.3e-16 59.9 0.5 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK56441.1 - 4.4e-26 90.5 8.0 2.3e-06 27.3 0.3 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK56441.1 - 2.9e-15 56.4 6.5 0.0017 18.7 0.1 4.7 4 0 0 4 4 4 4 PDZ domain PDZ_4 PF17816.1 PIK56441.1 - 0.21 12.0 2.6 12 6.4 0.0 4.3 4 1 1 5 5 5 0 PDZ domain zf-C2HC PF01530.18 PIK56441.1 - 3.5 7.9 20.0 1.9e+02 2.3 0.0 7.7 8 0 0 8 8 8 0 Zinc finger, C2HC type PDZ PF00595.24 PIK56442.1 - 1.7e-18 66.7 0.4 1.9e-18 66.6 0.4 1.0 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK56442.1 - 1.7e-08 34.1 0.1 2.2e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK56442.1 - 0.00017 21.8 0.1 0.0002 21.6 0.1 1.2 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 PIK56442.1 - 0.064 13.2 0.1 0.082 12.9 0.1 1.2 1 0 0 1 1 1 0 Tricorn protease PDZ domain HYR PF02494.16 PIK56443.1 - 2.1e-259 838.7 101.0 4e-25 88.0 3.6 11.3 11 0 0 11 11 11 11 HYR domain FAM194 PF14977.6 PIK56443.1 - 1e-05 24.9 16.5 3.9 6.7 0.1 8.4 8 0 0 8 8 8 3 FAM194 protein Gln-synt_N PF03951.19 PIK56443.1 - 0.00019 21.1 6.5 23 4.8 0.0 8.0 11 0 0 11 11 11 3 Glutamine synthetase, beta-Grasp domain FTR_C PF02741.15 PIK56443.1 - 0.66 10.0 5.4 56 3.7 0.0 5.0 6 0 0 6 6 6 0 FTR, proximal lobe HYR PF02494.16 PIK56444.1 - 5.2e-41 138.8 15.4 1.7e-21 76.3 2.3 3.5 3 0 0 3 3 3 2 HYR domain fn3 PF00041.21 PIK56444.1 - 8.3e-11 42.1 16.5 7.5e-06 26.2 1.1 5.5 5 1 0 5 5 5 4 Fibronectin type III domain Lactamase_B_2 PF12706.7 PIK56444.1 - 0.00096 18.7 0.2 0.73 9.3 0.0 2.8 3 1 0 3 3 3 2 Beta-lactamase superfamily domain PA_decarbox PF05870.11 PIK56444.1 - 0.006 16.2 0.1 0.41 10.3 0.0 2.3 2 0 0 2 2 2 1 Phenolic acid decarboxylase (PAD) DUF5011 PF16403.5 PIK56444.1 - 0.11 12.7 0.2 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Y_phosphatase PF00102.27 PIK56445.1 - 8.8e-37 126.9 0.0 1.1e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF4218 PF13960.6 PIK56446.1 - 1e-06 28.4 0.0 2.1e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Transposase_21 PF02992.14 PIK56446.1 - 0.019 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Transposase family tnp2 IRF PF00605.17 PIK56447.1 - 9.5e-35 119.1 0.0 1.1e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor DUF4342 PF14242.6 PIK56447.1 - 0.068 13.2 0.1 0.52 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Glyco_hydro81C PF17652.1 PIK56449.1 - 0.025 13.8 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 81 C-terminal domain Homeodomain PF00046.29 PIK56450.1 - 0.004 17.0 4.4 0.0099 15.7 4.4 1.7 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 PIK56450.1 - 0.066 13.1 1.0 0.13 12.1 1.0 1.5 1 0 0 1 1 1 0 OAR domain TPR_8 PF13181.6 PIK56451.1 - 1.2e-05 25.1 1.2 0.018 15.2 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56451.1 - 1.5e-05 24.7 0.7 0.04 14.0 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56451.1 - 0.00014 21.5 1.7 0.0048 16.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56451.1 - 0.00092 19.7 0.9 2 9.0 0.1 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56451.1 - 0.0022 18.7 3.5 1.1 10.3 0.4 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK56451.1 - 0.0032 17.7 3.1 0.73 10.1 0.0 3.8 1 1 4 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 PIK56451.1 - 0.0033 17.4 7.9 0.02 15.0 0.5 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK56451.1 - 0.0036 17.6 1.0 0.11 13.0 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK56451.1 - 0.0053 17.3 0.4 0.75 10.6 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Mt_ATP_synt PF15704.5 PIK56451.1 - 0.087 12.7 0.4 0.2 11.6 0.4 1.6 1 1 0 1 1 1 0 Mitochondrial ATP synthase subunit DUF1796 PF08795.10 PIK56451.1 - 0.1 12.6 2.4 0.44 10.5 2.4 2.0 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) TPR_16 PF13432.6 PIK56451.1 - 0.1 13.2 0.3 0.1 13.2 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 PIK56451.1 - 0.16 12.0 3.8 0.76 9.8 1.0 2.8 2 1 1 3 3 3 0 Mad3/BUB1 homology region 1 BTG PF07742.12 PIK56451.1 - 0.19 11.6 1.0 0.56 10.1 0.2 2.2 2 1 1 3 3 3 0 BTG family TPR_12 PF13424.6 PIK56451.1 - 0.35 11.2 4.3 3.8 7.9 0.5 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56451.1 - 6.8 6.7 10.8 6.5 6.8 0.4 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat RVT_1 PF00078.27 PIK56452.1 - 0.00022 20.8 0.0 0.00043 19.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPR_17 PF13431.6 PIK56453.1 - 4e-09 36.2 0.3 0.0045 17.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56453.1 - 1.3e-08 35.2 5.5 0.53 10.8 0.0 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56453.1 - 7.8e-08 31.9 0.5 0.0065 16.1 0.0 4.3 4 0 0 4 4 4 2 TPR repeat TPR_1 PF00515.28 PIK56453.1 - 2.2e-07 30.4 10.1 0.011 15.5 0.4 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56453.1 - 1.1e-05 25.8 6.6 0.91 10.5 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56453.1 - 0.00022 21.2 13.2 0.019 15.1 0.2 4.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56453.1 - 0.00052 19.9 21.5 0.025 14.7 1.0 5.8 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56453.1 - 0.0016 18.3 9.6 0.11 12.5 0.5 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56453.1 - 0.0063 17.1 2.8 0.23 12.1 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK56453.1 - 0.04 14.0 0.2 4.1 7.5 0.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_12 PF13424.6 PIK56453.1 - 0.049 13.9 15.1 4.5 7.6 0.8 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK56453.1 - 0.091 13.0 8.2 2.7 8.3 0.1 4.2 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 PIK56453.1 - 0.093 13.4 7.7 1 10.2 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Lyase_1 PF00206.20 PIK56454.1 - 2e-17 63.6 0.0 1.3e-09 37.9 0.0 2.1 1 1 1 2 2 2 2 Lyase EPTP PF03736.17 PIK56455.1 - 2.3e-06 27.5 0.6 0.036 14.1 0.0 3.1 2 1 2 4 4 4 2 EPTP domain G6PD_C PF02781.16 PIK56455.1 - 0.093 11.9 0.7 0.33 10.1 0.1 1.8 1 1 1 2 2 2 0 Glucose-6-phosphate dehydrogenase, C-terminal domain BppL_N PF18338.1 PIK56456.1 - 1e-28 97.9 72.7 0.015 15.0 1.0 18.9 19 0 0 19 19 19 14 Lower baseplate protein N-terminal domain EPTP PF03736.17 PIK56456.1 - 2.4e-10 40.2 1.3 0.0028 17.6 0.5 3.8 3 0 0 3 3 3 3 EPTP domain Bactofilin PF04519.13 PIK56456.1 - 0.0055 17.0 37.9 0.35 11.2 2.0 10.1 4 4 5 9 9 9 4 Polymer-forming cytoskeletal ELO PF01151.18 PIK56457.1 - 1.1e-50 172.5 18.0 1.4e-50 172.2 18.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Glyco_hydro_31 PF01055.26 PIK56458.1 - 6e-158 526.6 0.2 8e-158 526.2 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK56458.1 - 1.4e-28 99.5 0.1 2.4e-28 98.7 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 PIK56458.1 - 7.9e-13 48.1 9.3 1.9e-12 46.9 9.3 1.7 1 0 0 1 1 1 1 Trefoil (P-type) domain DUF5110 PF17137.4 PIK56458.1 - 6.4e-05 23.1 1.5 0.00012 22.2 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) LRR_8 PF13855.6 PIK56459.1 - 7.8e-27 92.8 24.6 7e-12 44.9 2.9 4.1 2 1 3 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 PIK56459.1 - 2.9e-10 40.2 20.2 5.4e-06 26.7 3.1 4.4 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK56459.1 - 1.6e-05 24.8 12.2 0.064 13.8 0.2 5.4 4 2 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK56459.1 - 0.0016 17.9 5.5 0.039 13.4 3.5 2.4 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 PIK56459.1 - 0.0036 17.2 13.0 0.075 13.1 0.7 4.9 5 0 0 5 5 5 1 Leucine Rich repeat GBR_NSP5 PF17580.2 PIK56459.1 - 0.12 12.2 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 LRR_8 PF13855.6 PIK56460.1 - 1.2e-26 92.3 22.9 5.5e-12 45.3 2.3 3.7 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 PIK56460.1 - 5.1e-10 39.4 14.5 1.6e-06 28.4 1.2 4.1 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK56460.1 - 4.9e-06 26.4 10.0 0.073 13.6 0.2 5.2 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK56460.1 - 3.1e-05 24.0 0.2 5.7e-05 23.1 0.2 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK56460.1 - 0.0019 17.7 5.3 0.014 14.9 3.4 2.3 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 PIK56460.1 - 0.002 18.0 12.1 0.085 13.0 0.7 4.8 5 0 0 5 5 5 1 Leucine Rich repeat GBR_NSP5 PF17580.2 PIK56460.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 Syntaxin-6_N PF09177.11 PIK56461.1 - 0.0013 19.2 7.1 0.0018 18.8 7.1 1.2 1 0 0 1 1 1 1 Syntaxin 6, N-terminal HOOK PF05622.12 PIK56461.1 - 0.012 13.8 11.4 0.015 13.5 11.4 1.1 1 0 0 1 1 1 0 HOOK protein Tropomyosin_1 PF12718.7 PIK56461.1 - 0.019 15.2 11.0 0.019 15.2 11.0 1.4 1 1 0 1 1 1 0 Tropomyosin like NleF_casp_inhib PF16809.5 PIK56461.1 - 0.022 14.7 7.0 0.1 12.5 1.2 2.1 1 1 1 2 2 2 0 NleF caspase inhibitor Jnk-SapK_ap_N PF09744.9 PIK56461.1 - 0.025 14.8 11.5 0.032 14.5 11.5 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 PIK56461.1 - 0.025 13.5 11.8 0.03 13.2 11.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein CALCOCO1 PF07888.11 PIK56461.1 - 0.03 13.2 11.7 0.035 13.0 11.7 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GIT_CC PF16559.5 PIK56461.1 - 0.03 14.2 3.1 0.03 14.2 3.1 2.1 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CorA PF01544.18 PIK56461.1 - 0.034 13.5 5.9 0.042 13.2 5.9 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein MIP-T3 PF10243.9 PIK56461.1 - 0.035 14.1 1.5 0.039 13.9 0.6 1.5 2 0 0 2 2 1 0 Microtubule-binding protein MIP-T3 CH-like domain Csm1_N PF18504.1 PIK56461.1 - 0.048 14.0 6.8 0.048 14.0 6.8 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain SlyX PF04102.12 PIK56461.1 - 0.055 14.1 4.7 0.055 14.1 4.7 3.2 1 1 2 3 3 3 0 SlyX Fmp27_WPPW PF10359.9 PIK56461.1 - 0.075 11.9 8.3 0.081 11.8 8.3 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain BLOC1_2 PF10046.9 PIK56461.1 - 0.13 12.6 9.4 0.27 11.5 9.4 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 S6OS1 PF15676.5 PIK56461.1 - 0.22 10.0 7.6 0.33 9.4 7.6 1.3 1 1 0 1 1 1 0 Six6 opposite strand transcript 1 family Cnn_1N PF07989.11 PIK56461.1 - 0.23 11.6 10.7 0.1 12.8 6.4 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 V_ATPase_I PF01496.19 PIK56461.1 - 0.23 9.3 7.3 0.26 9.1 7.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.20 PIK56461.1 - 0.26 11.2 17.3 5.1 7.1 17.3 2.1 1 1 0 1 1 1 0 Prefoldin subunit Exonuc_VII_L PF02601.15 PIK56461.1 - 0.27 10.8 7.1 0.32 10.5 7.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Blo-t-5 PF11642.8 PIK56461.1 - 0.29 11.1 8.4 0.13 12.3 2.7 2.0 1 1 1 2 2 2 0 Mite allergen Blo t 5 DUF2203 PF09969.9 PIK56461.1 - 0.31 11.8 5.9 0.43 11.3 5.9 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 PIK56461.1 - 0.34 10.9 7.2 0.53 10.3 7.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 PIK56461.1 - 0.41 10.0 8.3 0.51 9.6 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 PIK56461.1 - 0.42 10.8 9.8 0.67 10.1 9.8 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 PIK56461.1 - 0.43 11.0 7.0 0.089 13.2 2.6 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 PIK56461.1 - 0.45 10.8 6.7 0.56 10.5 4.2 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Lectin_N PF03954.14 PIK56461.1 - 0.46 10.2 7.2 0.22 11.3 4.9 1.6 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF4094 PF13334.6 PIK56461.1 - 0.49 10.8 7.0 1.5 9.3 6.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) DUF16 PF01519.16 PIK56461.1 - 0.56 10.7 15.9 0.067 13.7 8.3 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 FAM76 PF16046.5 PIK56461.1 - 0.75 9.1 7.8 0.86 8.9 7.8 1.0 1 0 0 1 1 1 0 FAM76 protein DUF4795 PF16043.5 PIK56461.1 - 0.91 9.1 11.4 14 5.2 1.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) TMF_DNA_bd PF12329.8 PIK56461.1 - 0.98 9.5 12.3 0.2 11.7 7.4 2.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.13 PIK56461.1 - 1 9.5 14.0 0.72 10.0 8.1 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF3450 PF11932.8 PIK56461.1 - 1.1 8.6 16.0 2.3 7.5 16.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 PIK56461.1 - 1.2 9.7 17.7 3.3 8.2 17.6 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region COG2 PF06148.11 PIK56461.1 - 1.2 9.2 8.2 0.53 10.4 4.9 1.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 M PF02370.16 PIK56461.1 - 1.5 9.7 10.4 6.2 7.7 0.5 3.9 3 0 0 3 3 3 0 M protein repeat Cauli_AT PF03233.13 PIK56461.1 - 1.6 8.7 9.1 2.3 8.1 4.6 2.0 1 1 1 2 2 2 0 Aphid transmission protein Corona_S2 PF01601.16 PIK56461.1 - 1.6 7.1 6.4 1.9 6.9 6.4 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF724 PF05266.14 PIK56461.1 - 2.2 8.0 12.4 2.9 7.7 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ABC_tran_CTD PF16326.5 PIK56461.1 - 2.3 8.5 11.7 0.44 10.8 2.5 2.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain Sec2p PF06428.11 PIK56461.1 - 2.7 8.0 15.9 3.1 7.8 2.0 2.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Sec34 PF04136.15 PIK56461.1 - 2.8 7.8 11.1 2.2 8.1 3.0 2.1 1 1 1 2 2 2 0 Sec34-like family UPF0242 PF06785.11 PIK56461.1 - 3.5 7.7 18.6 4 7.5 17.7 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 PIK56461.1 - 4.3 6.5 9.6 2.3 7.4 7.2 1.6 1 1 1 2 2 2 0 TMPIT-like protein Atg14 PF10186.9 PIK56461.1 - 6.5 5.7 13.3 8.5 5.4 13.3 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc24 PF08286.11 PIK56461.1 - 10 6.5 13.1 3.7 7.8 6.7 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Voltage_CLC PF00654.20 PIK56463.1 - 4.6e-89 299.1 25.6 4.6e-89 299.1 25.6 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 PIK56463.1 - 6.3e-16 58.6 0.1 1.7e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 CBS domain DUF5641 PF18701.1 PIK56464.1 - 9.9e-18 64.1 1.0 1.8e-17 63.3 1.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DUF3104 PF11302.8 PIK56464.1 - 0.14 12.0 0.0 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) RVT_1 PF00078.27 PIK56465.1 - 5.4e-15 55.5 0.1 1e-14 54.6 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Beta-lactamase PF00144.24 PIK56467.1 - 2.2e-12 46.9 0.0 3.8e-06 26.4 0.0 2.3 1 1 0 2 2 2 2 Beta-lactamase Beta-lactamase PF00144.24 PIK56468.1 - 2.7e-46 158.3 0.1 5.2e-45 154.1 0.0 2.0 1 1 1 2 2 2 2 Beta-lactamase Amino_oxidase PF01593.24 PIK56469.1 - 2.3e-21 76.6 0.0 2.8e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK56469.1 - 9.7e-14 51.4 0.1 1.8e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK56469.1 - 5.5e-08 32.3 0.0 8.2e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 PIK56469.1 - 5.3e-07 29.5 0.5 6e-07 29.4 0.5 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK56469.1 - 2.5e-06 26.8 0.2 3.4e-06 26.4 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK56469.1 - 0.00017 20.9 0.0 0.00023 20.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK56469.1 - 0.0003 19.6 0.1 0.00045 19.1 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Mqo PF06039.15 PIK56469.1 - 0.0006 18.5 0.0 0.00083 18.0 0.0 1.2 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 PIK56469.1 - 0.0011 18.1 0.1 0.0015 17.7 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 PIK56469.1 - 0.0036 16.2 0.3 0.009 14.9 0.1 1.6 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 PIK56469.1 - 0.0042 16.5 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK56469.1 - 0.0065 15.6 0.1 0.0084 15.2 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 PIK56469.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 PIK56469.1 - 0.022 15.3 1.1 0.071 13.7 0.1 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK56469.1 - 0.08 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK56469.1 - 0.11 12.4 0.2 0.24 11.4 0.1 1.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 PIK56470.1 - 1.7e-21 77.0 0.0 2.2e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GATase PF00117.28 PIK56471.1 - 9.5e-05 22.2 0.5 0.00041 20.2 0.5 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 PIK56471.1 - 0.0016 18.3 0.0 0.006 16.4 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 DUF2015 PF09435.10 PIK56471.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) Galactosyl_T PF01762.21 PIK56472.1 - 2.1e-46 158.2 0.0 3.9e-46 157.3 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 PIK56473.1 - 1.3e-46 158.9 0.1 2.4e-46 158.0 0.1 1.4 1 0 0 1 1 1 1 Galactosyltransferase RVT_1 PF00078.27 PIK56474.1 - 2.7e-25 89.2 0.0 4.9e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK56474.1 - 2.7e-20 72.2 0.3 6.7e-20 71.0 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56474.1 - 2.9e-16 59.7 0.0 6.3e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK56474.1 - 4.1e-15 55.6 0.0 1.1e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK56474.1 - 9.3e-07 29.0 0.1 2.9e-06 27.4 0.1 1.9 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 PIK56474.1 - 3.2e-06 27.0 3.6 8.9e-06 25.6 3.6 1.8 1 0 0 1 1 1 1 Zinc knuckle RT_RNaseH PF17917.1 PIK56474.1 - 0.00099 19.4 0.0 0.0026 18.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC_5 PF14787.6 PIK56474.1 - 0.024 14.3 2.4 0.06 13.1 2.4 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 PIK56474.1 - 0.043 13.6 2.9 0.1 12.5 2.9 1.6 1 0 0 1 1 1 0 Zinc knuckle CALM_bind PF16025.5 PIK56475.1 - 7.6e-15 55.1 0.7 7.6e-15 55.1 0.7 3.0 3 0 0 3 3 3 1 Calcium-dependent calmodulin binding Glyco_transf_29 PF00777.18 PIK56476.1 - 1e-20 74.3 0.1 2e-20 73.3 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) WD40 PF00400.32 PIK56477.1 - 1e-18 67.3 14.6 1.4e-07 32.1 1.3 7.1 7 1 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56477.1 - 1.2e-07 31.9 0.1 0.0099 16.2 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK56477.1 - 4.2e-05 23.0 0.2 0.038 13.3 0.0 3.4 3 1 1 4 4 4 2 WD40-like domain Sec7 PF01369.20 PIK56478.1 - 1.2e-67 227.2 0.0 1.5e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain TFA2_Winged_2 PF18121.1 PIK56478.1 - 0.0063 16.2 1.4 0.013 15.2 1.4 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 BBS2_C PF14782.6 PIK56478.1 - 0.07 11.9 0.3 0.096 11.4 0.3 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal CCDC158 PF15921.5 PIK56478.1 - 0.23 9.3 1.4 0.3 8.8 1.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Y_phosphatase PF00102.27 PIK56479.1 - 1e-109 365.6 2.1 5.8e-56 189.7 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK56479.1 - 1.5e-09 37.8 0.1 0.0012 18.7 0.1 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK56479.1 - 2.1e-05 24.6 0.1 0.076 13.0 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK56479.1 - 4.9e-05 23.5 0.0 0.0036 17.4 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK56479.1 - 0.0047 16.5 0.2 0.87 9.2 0.0 2.6 2 0 0 2 2 2 2 Tyrosine phosphatase family Myotub-related PF06602.14 PIK56479.1 - 0.0087 15.0 0.4 3.9 6.3 0.0 2.6 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Kinesin PF00225.23 PIK56479.1 - 0.02 13.9 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Kinesin motor domain fn3 PF00041.21 PIK56480.1 - 3.2e-14 53.0 0.9 8.5e-14 51.7 0.2 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK56480.1 - 8e-06 26.4 0.7 2.2e-05 24.9 0.1 2.0 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 PIK56480.1 - 0.00079 19.8 12.2 0.00079 19.8 12.2 6.4 4 2 0 4 4 4 1 EGF-like domain Stevor PF17410.2 PIK56480.1 - 0.0022 17.6 0.1 0.0035 16.9 0.1 1.2 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame hEGF PF12661.7 PIK56480.1 - 0.0075 16.9 4.9 0.0075 16.9 4.9 5.6 6 1 0 6 6 6 1 Human growth factor-like EGF fn3_2 PF16893.5 PIK56480.1 - 0.015 15.4 0.4 0.075 13.2 0.4 2.0 1 1 0 1 1 1 0 Fibronectin type III domain DUF2207 PF09972.9 PIK56480.1 - 0.069 11.9 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4750 PF15938.5 PIK56480.1 - 6.3 6.5 5.8 11 5.7 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) HYR PF02494.16 PIK56481.1 - 8.6e-78 256.7 42.0 6.3e-13 48.9 2.8 8.3 8 0 0 8 8 8 8 HYR domain EGF PF00008.27 PIK56481.1 - 6.6e-21 74.3 46.5 2.4e-07 30.9 5.8 5.8 5 0 0 5 5 5 4 EGF-like domain EGF_2 PF07974.13 PIK56481.1 - 1.7e-08 34.7 47.1 0.0047 17.3 5.5 5.0 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK56481.1 - 1e-07 32.3 47.7 0.00018 22.0 1.0 6.4 7 0 0 7 7 7 3 Human growth factor-like EGF Laminin_EGF PF00053.24 PIK56481.1 - 0.00069 19.7 37.9 0.052 13.7 2.0 4.8 2 2 2 4 4 4 3 Laminin EGF domain MAR_sialic_bdg PF10564.9 PIK56481.1 - 0.0025 17.8 3.6 0.43 10.7 0.1 3.7 3 0 0 3 3 3 2 Sialic-acid binding micronemal adhesive repeat EGF_3 PF12947.7 PIK56481.1 - 0.014 15.6 39.5 0.017 15.3 2.4 5.4 4 1 1 5 5 5 0 EGF domain HYR PF02494.16 PIK56482.1 - 0 1571.7 229.9 5.6e-25 87.5 3.7 24.0 22 2 2 24 24 24 24 HYR domain TF_Zn_Ribbon PF08271.12 PIK56482.1 - 3.9e-06 26.3 19.6 0.96 9.0 0.5 5.5 4 0 0 4 4 4 4 TFIIB zinc-binding SH3_12 PF18129.1 PIK56482.1 - 1.1e-05 25.4 20.5 8.2 6.6 0.2 8.6 7 0 0 7 7 7 1 Xrn1 SH3-like domain PA_decarbox PF05870.11 PIK56482.1 - 7.5e-05 22.4 18.1 2.2 7.9 0.0 9.6 12 0 0 12 12 12 2 Phenolic acid decarboxylase (PAD) Maelstrom PF13017.6 PIK56482.1 - 0.0016 18.1 1.0 6 6.5 0.0 4.5 7 0 0 7 7 7 1 piRNA pathway germ-plasm component PDGF_N PF04692.13 PIK56482.1 - 0.0017 19.1 0.0 88 4.0 0.0 5.2 5 0 0 5 5 5 0 Platelet-derived growth factor, N terminal region US2 PF02476.15 PIK56482.1 - 0.014 16.1 2.3 48 4.7 0.0 5.0 5 0 0 5 5 5 0 US2 family VWA_3_C PF18571.1 PIK56482.1 - 0.05 13.5 6.0 1.2e+02 2.6 0.0 5.9 7 0 0 7 7 7 0 von Willebrand factor type A C-terminal domain RT_RNaseH_2 PF17919.1 PIK56483.1 - 1e-23 83.2 0.0 2.6e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56483.1 - 2.9e-17 62.8 0.0 7.1e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56483.1 - 5.7e-15 55.4 0.0 1.2e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK56483.1 - 2.3e-12 46.8 0.0 8.9e-12 44.9 0.0 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain RVP PF00077.20 PIK56483.1 - 7.2e-09 35.9 0.1 1.9e-08 34.5 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK56483.1 - 2.7e-06 27.9 0.0 5.8e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK56483.1 - 0.00043 20.9 0.0 0.001 19.7 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 PIK56483.1 - 0.0027 17.7 18.5 0.032 14.3 4.4 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK56483.1 - 2.1 8.1 14.0 1.4 8.7 4.2 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger rve PF00665.26 PIK56484.1 - 9.4e-15 54.9 0.0 2.3e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK56484.1 - 8.5e-05 22.3 0.0 0.00018 21.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Asp_Arg_Hydrox PF05118.15 PIK56485.1 - 1.6e-46 158.0 0.1 2.5e-46 157.4 0.1 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase PMP22_Claudin PF00822.20 PIK56485.1 - 0.037 13.9 0.2 5.2 6.9 0.1 2.3 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family GIT1_C PF12205.8 PIK56486.1 - 3.3e-33 114.3 0.3 3.3e-33 114.3 0.3 2.1 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term ArfGap PF01412.18 PIK56486.1 - 4.5e-25 88.0 1.2 1.2e-24 86.7 0.0 2.3 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf GIT_SHD PF08518.11 PIK56486.1 - 2.1e-24 84.8 7.4 1.3e-13 50.3 1.7 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT_CC PF16559.5 PIK56486.1 - 1.2e-17 63.5 3.6 2.9e-17 62.3 3.6 1.6 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor Ank_2 PF12796.7 PIK56486.1 - 1.1e-07 32.3 0.0 2.3e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK56486.1 - 1.4e-06 28.5 0.0 4.8e-06 26.8 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK56486.1 - 0.0016 18.8 0.1 0.0075 16.7 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 PIK56486.1 - 0.0041 17.6 0.0 0.21 12.2 0.0 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) KASH_CCD PF14662.6 PIK56486.1 - 0.017 15.0 3.8 0.044 13.6 3.8 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 PIK56486.1 - 0.026 15.1 2.1 0.094 13.4 2.1 1.9 1 0 0 1 1 1 0 Initiation control protein YabA Ank_3 PF13606.6 PIK56486.1 - 0.035 14.6 0.0 13 6.7 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat ZapB PF06005.12 PIK56486.1 - 0.16 12.5 3.4 0.6 10.6 3.4 2.0 1 0 0 1 1 1 0 Cell division protein ZapB Sigma70_ner PF04546.13 PIK56486.1 - 0.28 11.1 9.1 2 8.2 0.7 3.2 3 1 0 3 3 3 0 Sigma-70, non-essential region DUF3450 PF11932.8 PIK56486.1 - 0.48 9.7 3.1 0.23 10.7 0.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) BLOC1_2 PF10046.9 PIK56486.1 - 1.2 9.5 9.7 0.14 12.5 4.7 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ndc1_Nup PF09531.10 PIK56486.1 - 3 6.4 9.1 4.5 5.8 9.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3342 PF11822.8 PIK56487.1 - 5.4e-26 90.6 1.2 1.4e-25 89.3 1.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) CHORD PF04968.12 PIK56487.1 - 0.0011 19.7 6.3 0.0011 19.7 6.3 2.2 2 0 0 2 2 2 1 CHORD Myb_DNA-bind_6 PF13921.6 PIK56487.1 - 0.0023 18.2 0.0 0.0067 16.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 PIK56487.1 - 0.014 15.6 0.0 0.041 14.1 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain LSM PF01423.22 PIK56488.1 - 3.7e-15 55.3 0.1 5.4e-15 54.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain RPA_interact_C PF14768.6 PIK56489.1 - 5.2e-20 71.8 2.2 1.4e-19 70.4 2.2 1.8 1 0 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.6 PIK56489.1 - 0.00011 22.7 12.3 0.00027 21.4 12.3 1.7 1 0 0 1 1 1 1 Replication protein A interacting middle RPA_interact_N PF14766.6 PIK56489.1 - 0.00011 21.7 3.7 0.00011 21.7 3.7 1.6 2 0 0 2 2 2 1 Replication protein A interacting N-terminal A2L_zn_ribbon PF08792.10 PIK56489.1 - 0.017 14.8 1.4 0.017 14.8 1.4 2.0 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF1241 PF06840.11 PIK56489.1 - 0.049 13.3 0.4 0.26 10.9 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1241) DUF1644 PF07800.12 PIK56489.1 - 0.057 13.5 2.7 0.33 11.0 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) DUF2325 PF10087.9 PIK56489.1 - 0.088 12.9 0.2 0.66 10.1 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) zf-RING_10 PF16685.5 PIK56489.1 - 0.37 11.0 4.3 0.91 9.7 0.4 2.4 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-HIT PF04438.16 PIK56490.1 - 2.7e-09 36.7 6.4 3.9e-09 36.2 6.4 1.3 1 0 0 1 1 1 1 HIT zinc finger Rabaptin PF03528.15 PIK56491.1 - 2.1e-50 171.8 57.9 3.7e-40 138.1 37.8 5.5 4 2 0 5 5 5 2 Rabaptin Rab5-bind PF09311.11 PIK56491.1 - 1.2e-46 159.6 49.6 1.2e-46 159.6 49.6 4.4 3 2 0 4 4 4 1 Rabaptin-like protein FYVE PF01363.21 PIK56491.1 - 3.7e-10 39.8 12.8 8.6e-10 38.6 12.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger PsaN PF05479.11 PIK56491.1 - 0.028 14.6 0.7 0.094 12.9 0.0 2.2 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Hydrolase_4 PF12146.8 PIK56492.1 - 4.5e-08 32.6 0.0 8.1e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK56492.1 - 0.0016 18.2 0.0 0.004 16.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 PIK56492.1 - 0.03 13.9 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) GST_C PF00043.25 PIK56494.1 - 5.6e-09 36.1 0.0 1e-08 35.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK56494.1 - 4.2e-07 30.1 0.1 1.8e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56494.1 - 7.3e-07 29.4 0.0 1.4e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK56494.1 - 1.9e-06 28.2 0.0 4.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK56494.1 - 6.3e-06 26.1 0.0 1.7e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK56494.1 - 0.0015 18.8 0.0 0.0056 17.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 PIK56494.1 - 0.0025 18.1 0.0 0.0075 16.6 0.0 1.8 1 1 1 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 PIK56494.1 - 0.017 14.9 0.0 0.041 13.7 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56495.1 - 1e-11 45.0 0.0 1.8e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK56495.1 - 7.8e-11 42.2 0.0 1.4e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK56495.1 - 1.6e-09 37.9 0.0 3.7e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK56495.1 - 2.9e-07 30.6 0.1 7.1e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK56495.1 - 5.4e-06 26.6 0.0 1.2e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK56495.1 - 1.3e-05 25.2 0.0 2.8e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK56495.1 - 0.0029 17.3 0.0 0.0085 15.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Ski2_N PF17911.1 PIK56496.1 - 1.3e-34 118.9 0.4 3e-34 117.7 0.0 1.7 2 0 0 2 2 2 1 Ski2 N-terminal region DEAD PF00270.29 PIK56496.1 - 0.02 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Methyltransf_25 PF13649.6 PIK56496.1 - 0.048 14.4 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DSHCT PF08148.12 PIK56497.1 - 2.3e-13 50.1 0.0 4.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 PIK56497.1 - 1.9e-07 31.3 0.0 3.3e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain RhoGAP PF00620.27 PIK56499.1 - 7.7e-23 81.0 0.0 9e-23 80.8 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain START PF01852.19 PIK56500.1 - 8.3e-36 123.4 0.2 1.7e-35 122.3 0.1 1.5 2 0 0 2 2 2 1 START domain RhoGAP PF00620.27 PIK56500.1 - 0.036 13.9 0.1 0.077 12.8 0.1 1.5 1 0 0 1 1 1 0 RhoGAP domain RVT_2 PF07727.14 PIK56501.1 - 7.2e-79 264.8 2.1 9.6e-79 264.4 2.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF432 PF04254.13 PIK56501.1 - 0.023 14.9 0.2 0.046 13.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF432) rve PF00665.26 PIK56502.1 - 9e-13 48.5 0.0 1.9e-11 44.2 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 PIK56502.1 - 0.0061 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain WTF PF03303.13 PIK56503.1 - 0.0014 18.4 0.1 0.0032 17.2 0.0 1.6 1 1 1 2 2 2 1 WTF protein Peptidase_M50B PF13398.6 PIK56503.1 - 0.018 14.7 0.2 0.028 14.1 0.2 1.3 1 0 0 1 1 1 0 Peptidase M50B-like RED_C PF07807.11 PIK56504.1 - 1.6e-53 180.0 3.5 1.9e-53 179.7 3.5 1.1 1 0 0 1 1 1 1 RED-like protein C-terminal region FlgO PF17680.1 PIK56504.1 - 0.027 14.2 0.1 0.036 13.8 0.1 1.1 1 0 0 1 1 1 0 FlgO protein RED_N PF07808.13 PIK56505.1 - 4e-97 324.4 18.9 4e-97 324.4 18.9 2.2 2 0 0 2 2 2 1 RED-like protein N-terminal region UQ_con PF00179.26 PIK56506.1 - 3.3e-52 175.9 0.1 4e-52 175.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 PIK56506.1 - 0.00046 20.5 0.1 0.00057 20.1 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 PIK56506.1 - 0.0025 17.5 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 PIK56506.1 - 0.033 14.0 0.1 0.049 13.5 0.1 1.4 1 0 0 1 1 1 0 UEV domain DUF5487 PF17589.2 PIK56506.1 - 0.078 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5487) Peptidase_C78 PF07910.13 PIK56507.1 - 1.6e-11 44.1 0.2 4e-08 33.0 0.0 2.8 2 1 1 3 3 3 2 Peptidase family C78 Mito_carr PF00153.27 PIK56508.1 - 4.9e-66 218.7 5.1 8.9e-25 86.5 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 PIK56508.1 - 0.0028 16.9 1.0 0.019 14.1 0.1 2.4 1 1 0 2 2 2 1 Gammaproteobacterial serine protease Sulfatase PF00884.23 PIK56509.1 - 3.2e-55 187.7 0.0 6.3e-55 186.7 0.0 1.5 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 PIK56509.1 - 6.7e-09 35.8 0.3 9.3e-08 32.0 0.3 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 PIK56509.1 - 5.3e-07 29.8 1.6 3.9e-05 23.8 1.1 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4976) DUF229 PF02995.17 PIK56509.1 - 4.2e-06 25.6 0.0 8.3e-06 24.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase_C PF14707.6 PIK56509.1 - 0.031 15.0 0.0 0.065 14.0 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Metalloenzyme PF01676.18 PIK56509.1 - 0.055 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily DUF4994 PF16385.5 PIK56509.1 - 0.12 12.4 0.5 0.27 11.2 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function RabGAP-TBC PF00566.18 PIK56510.1 - 5.1e-29 101.5 0.1 5.1e-29 101.5 0.1 2.9 3 0 0 3 3 3 1 Rab-GTPase-TBC domain PID PF00640.23 PIK56510.1 - 1.3e-12 48.0 3.0 5.8e-10 39.3 0.3 3.5 3 0 0 3 3 3 2 Phosphotyrosine interaction domain (PTB/PID) DUF3350 PF11830.8 PIK56510.1 - 7.1e-10 39.1 4.6 7.1e-10 39.1 4.6 3.2 2 2 2 4 4 4 1 Domain of unknown function (DUF3350) PID_2 PF14719.6 PIK56510.1 - 0.00023 21.1 5.2 0.0013 18.7 0.1 3.8 3 1 1 4 4 4 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 PIK56510.1 - 0.0073 16.5 0.4 0.038 14.2 0.1 2.3 2 0 0 2 2 2 1 Phosphotyrosine-binding domain DUF4358 PF14270.6 PIK56510.1 - 0.014 15.6 0.3 0.34 11.2 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4358) ParD_antitoxin PF03693.14 PIK56510.1 - 0.029 14.8 0.0 0.91 10.0 0.0 2.8 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Melibiase_2 PF16499.5 PIK56511.1 - 4.8e-122 406.6 2.1 4.8e-122 406.6 2.1 1.4 2 0 0 2 2 2 1 Alpha galactosidase A Melibiase_2_C PF17450.2 PIK56511.1 - 1.1e-09 38.4 0.0 2.1e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase_C PF17801.1 PIK56511.1 - 2.3e-08 34.0 0.2 5.1e-07 29.7 0.1 2.6 3 0 0 3 3 3 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 PIK56511.1 - 1.9e-05 23.8 0.0 3.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_97 PF10566.9 PIK56511.1 - 0.0019 17.6 0.4 0.0043 16.4 0.0 1.7 2 0 0 2 2 2 1 Glycoside hydrolase 97 Kelch_1 PF01344.25 PIK56512.1 - 4e-81 266.4 22.0 3.1e-17 61.9 0.1 6.7 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 PIK56512.1 - 2.1e-49 164.3 5.7 1.8e-09 37.5 0.0 6.6 1 1 5 6 6 6 6 Kelch motif Kelch_4 PF13418.6 PIK56512.1 - 1.2e-33 114.8 4.3 6.1e-05 23.0 0.0 6.5 4 2 2 6 6 6 6 Galactose oxidase, central domain BACK PF07707.15 PIK56512.1 - 6.2e-29 100.1 0.1 6.2e-29 100.1 0.1 2.2 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 PIK56512.1 - 3.5e-28 96.5 6.0 0.0001 22.1 0.0 6.4 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 PIK56512.1 - 2.4e-27 95.3 1.9 4.2e-27 94.6 1.9 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 PIK56512.1 - 1.3e-23 82.7 12.0 0.00052 20.2 0.1 7.0 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK56512.1 - 3.3e-13 49.3 9.7 0.0038 17.2 0.0 6.2 6 0 0 6 6 6 4 Kelch motif DUF3342 PF11822.8 PIK56512.1 - 0.002 18.3 1.1 0.0044 17.2 0.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) DUF3553 PF12073.8 PIK56513.1 - 0.073 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) DNA_pol3_beta_3 PF02768.15 PIK56513.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III beta subunit, C-terminal domain IgGFc_binding PF17517.2 PIK56516.1 - 5.9e-37 127.5 1.4 5.9e-37 127.5 1.4 1.7 2 0 0 2 2 2 1 IgGFc binding protein Calx-beta PF03160.14 PIK56516.1 - 4.8e-09 36.3 0.1 0.0044 17.2 0.0 3.2 3 0 0 3 3 3 2 Calx-beta domain VWD PF00094.25 PIK56517.1 - 4.7e-16 59.4 1.2 5.9e-16 59.1 1.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type D domain VWD PF00094.25 PIK56518.1 - 6.9e-10 39.4 0.0 9.1e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type D domain VWD PF00094.25 PIK56519.1 - 6.9e-69 231.1 3.9 4.7e-24 85.5 0.0 4.5 4 0 0 4 4 4 4 von Willebrand factor type D domain TIL PF01826.17 PIK56519.1 - 4.4e-21 74.9 68.2 2.7e-10 40.3 14.6 16.3 8 5 6 14 14 14 4 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK56519.1 - 3.8e-18 65.2 60.9 2.3e-09 37.0 8.5 10.9 8 2 3 11 11 11 4 TILa domain EGF PF00008.27 PIK56519.1 - 9.2e-07 29.1 9.9 9.2e-07 29.1 9.9 15.2 17 1 0 17 17 17 4 EGF-like domain EGF_3 PF12947.7 PIK56519.1 - 2.1e-06 27.8 18.0 4.2e-05 23.6 3.1 13.1 14 1 0 14 14 14 5 EGF domain hEGF PF12661.7 PIK56519.1 - 0.002 18.7 8.6 0.002 18.7 8.6 16.9 17 1 0 17 17 17 3 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK56519.1 - 0.0026 17.7 6.4 0.0026 17.7 6.4 8.5 9 0 0 9 9 9 3 MSP1 EGF domain 1 VWD PF00094.25 PIK56520.1 - 1.2e-07 32.1 0.0 1.4e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type D domain OrfB_Zn_ribbon PF07282.11 PIK56520.1 - 0.01 15.7 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain VWD PF00094.25 PIK56521.1 - 8.9e-17 61.8 0.2 2.2e-16 60.5 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 PIK56521.1 - 4.6e-12 46.2 4.8 4.6e-12 46.2 4.8 3.9 3 1 0 3 3 3 1 C8 domain EGF PF00008.27 PIK56521.1 - 0.00019 21.6 6.9 0.00019 21.6 6.9 5.9 5 0 0 5 5 5 2 EGF-like domain CUB PF00431.20 PIK56521.1 - 0.0031 17.8 0.4 0.049 14.0 0.0 3.0 2 1 0 2 2 2 1 CUB domain hEGF PF12661.7 PIK56521.1 - 0.011 16.4 4.9 0.011 16.4 4.9 7.8 8 0 0 8 8 8 0 Human growth factor-like EGF SH2 PF00017.24 PIK56522.1 - 2e-18 66.3 0.3 6.6e-18 64.6 0.1 1.9 2 0 0 2 2 2 1 SH2 domain Pkinase_Tyr PF07714.17 PIK56522.1 - 2.3e-17 63.1 0.0 3.9e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56522.1 - 8.3e-11 41.7 0.0 1.4e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MeaB PF03308.16 PIK56523.1 - 2.2e-91 305.6 0.6 2.8e-91 305.2 0.6 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 PIK56523.1 - 1.8e-06 27.7 0.1 7.1e-06 25.7 0.1 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 PIK56523.1 - 7.1e-05 22.7 0.1 0.00015 21.7 0.1 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 PIK56523.1 - 0.00011 22.0 0.1 0.00022 21.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK56523.1 - 0.00062 20.1 0.8 0.048 13.9 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.6 PIK56523.1 - 0.0013 19.3 0.6 0.16 12.5 0.2 2.4 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 PIK56523.1 - 0.0015 18.5 0.2 0.0045 16.9 0.1 1.8 2 0 0 2 2 2 1 NTPase ABC_tran PF00005.27 PIK56523.1 - 0.0016 18.9 0.2 0.0052 17.3 0.1 1.8 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 PIK56523.1 - 0.0024 17.6 0.1 0.0053 16.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 PIK56523.1 - 0.0028 18.2 0.1 0.0068 17.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK56523.1 - 0.007 16.5 0.4 0.026 14.7 0.0 2.1 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 PIK56523.1 - 0.0077 16.3 0.1 0.3 11.2 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase IstB_IS21 PF01695.17 PIK56523.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 PIK56523.1 - 0.012 15.3 0.5 0.022 14.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 PIK56523.1 - 0.024 14.5 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase ArsA_ATPase PF02374.15 PIK56523.1 - 0.024 13.8 0.5 0.054 12.7 0.5 1.5 1 0 0 1 1 1 0 Anion-transporting ATPase CbiA PF01656.23 PIK56523.1 - 0.038 14.1 0.0 0.096 12.7 0.0 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KAP_NTPase PF07693.14 PIK56523.1 - 0.041 13.1 0.1 0.089 12.0 0.1 1.5 1 1 0 1 1 1 0 KAP family P-loop domain PRK PF00485.18 PIK56523.1 - 0.05 13.3 0.2 0.14 11.8 0.2 1.8 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family KTI12 PF08433.10 PIK56523.1 - 0.06 12.8 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 PIK56523.1 - 0.079 13.3 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 PIK56523.1 - 0.083 12.5 0.0 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 PIK56523.1 - 0.088 13.2 0.1 0.33 11.3 0.1 2.1 2 0 0 2 2 1 0 RNA helicase Mg_chelatase PF01078.21 PIK56523.1 - 0.095 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 PIK56523.1 - 0.1 13.1 0.6 0.23 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK56523.1 - 0.11 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 PIK56523.1 - 0.13 12.2 0.3 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain ParA PF10609.9 PIK56523.1 - 0.14 11.6 0.6 6.1 6.2 0.0 2.3 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_28 PF13521.6 PIK56523.1 - 0.16 12.2 1.1 0.56 10.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain HMMR_C PF15908.5 PIK56524.1 - 2.5e-38 131.8 17.0 2.5e-38 131.8 17.0 10.3 3 2 6 11 11 11 1 Hyaluronan mediated motility receptor C-terminal HMMR_N PF15905.5 PIK56524.1 - 5.6e-15 55.7 51.6 5.6e-15 55.7 51.6 9.9 1 1 8 9 9 9 3 Hyaluronan mediated motility receptor N-terminal HHV-5_US34A PF17087.5 PIK56524.1 - 0.044 13.9 0.4 0.32 11.2 0.4 2.6 1 0 0 1 1 1 0 Herpesvirus US34A protein family Pescadillo_N PF06732.11 PIK56525.1 - 2e-42 145.6 4.0 2.4e-42 145.4 4.0 1.0 1 0 0 1 1 1 1 Pescadillo N-terminus DUF3161 PF11362.8 PIK56526.1 - 3.7e-16 58.9 0.0 5.5e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3161) SKA2 PF16740.5 PIK56526.1 - 4.1e-12 45.9 6.3 2.2e-06 27.4 0.0 2.5 1 1 1 2 2 2 2 Spindle and kinetochore-associated protein 2 SKA1 PF07160.12 PIK56526.1 - 1.1e-06 28.6 2.4 1.7e-06 28.1 1.1 1.7 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 1 RRF PF01765.19 PIK56526.1 - 0.097 12.6 1.5 0.21 11.5 1.5 1.6 1 0 0 1 1 1 0 Ribosome recycling factor Pro_dh PF01619.18 PIK56526.1 - 0.2 11.2 2.5 1.2 8.6 1.3 2.0 2 0 0 2 2 2 0 Proline dehydrogenase Vfa1 PF08432.10 PIK56527.1 - 1.1 9.6 11.7 0.099 13.0 4.2 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 APH PF01636.23 PIK56528.1 - 7.5e-51 173.4 0.0 1.3e-50 172.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 PIK56528.1 - 1.1e-37 129.6 3.3 2.4e-37 128.5 3.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK56528.1 - 1.3e-15 57.4 0.0 3e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK56528.1 - 1.1e-14 54.9 1.6 2.1e-14 53.9 1.6 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HAD_2 PF13419.6 PIK56528.1 - 1.7e-12 47.8 0.0 4.6e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 PIK56528.1 - 5e-10 40.0 0.0 2.6e-09 37.7 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Acyl-CoA_dh_N PF02771.16 PIK56528.1 - 2.2e-08 34.8 0.0 5.3e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain EcKinase PF02958.20 PIK56528.1 - 1.9e-05 24.1 0.0 4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 PIK56528.1 - 0.0013 18.3 0.0 0.15 11.7 0.0 2.4 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 PIK56528.1 - 0.025 14.2 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Hydrolase_6 PF13344.6 PIK56528.1 - 0.034 14.3 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK56528.1 - 0.036 14.1 0.0 0.12 12.5 0.0 1.9 1 0 0 1 1 1 0 HAD-hyrolase-like SHOCT PF09851.9 PIK56528.1 - 0.33 10.8 2.5 1.1 9.1 2.5 2.0 1 0 0 1 1 1 0 Short C-terminal domain Cpn60_TCP1 PF00118.24 PIK56529.1 - 7.7e-125 417.3 11.0 9.2e-125 417.0 11.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SET PF00856.28 PIK56530.1 - 1.5e-13 51.5 0.2 9.3e-13 48.9 0.0 2.4 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 PIK56530.1 - 0.00039 20.4 17.1 0.00039 20.4 17.1 2.9 2 0 0 2 2 2 1 MYND finger TPR_12 PF13424.6 PIK56530.1 - 0.0023 18.2 0.8 1.8 8.9 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat KdpC PF02669.15 PIK56530.1 - 0.065 13.1 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain DUF4390 PF14334.6 PIK56530.1 - 0.17 11.3 0.0 39 3.6 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4390) TPR_12 PF13424.6 PIK56531.1 - 1.6e-24 85.9 9.9 3.2e-11 43.4 1.5 3.6 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56531.1 - 1.3e-22 78.1 4.7 0.0027 17.6 0.0 5.5 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56531.1 - 8.2e-19 66.6 7.4 6.1e-05 22.7 0.1 5.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56531.1 - 3.8e-14 52.0 0.4 0.0036 17.1 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56531.1 - 1.2e-09 37.7 8.1 0.11 12.7 0.1 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56531.1 - 9.4e-09 34.7 7.9 0.12 12.6 0.1 5.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK56531.1 - 1.5e-06 27.8 4.2 4.8e-05 22.9 2.2 2.3 1 1 1 2 2 2 1 MalT-like TPR region DUF4807 PF16065.5 PIK56531.1 - 2.1e-05 24.2 4.2 0.17 11.6 0.1 3.8 1 1 2 3 3 3 3 Domain of unknown function (DUF4807) Rapsyn_N PF10579.9 PIK56531.1 - 0.0001 22.3 1.8 0.77 9.9 0.0 4.1 2 2 2 4 4 4 1 Rapsyn N-terminal myristoylation and linker region TPR_11 PF13414.6 PIK56531.1 - 0.00037 20.1 6.9 0.61 9.8 0.0 5.3 7 0 0 7 7 7 1 TPR repeat TPR_4 PF07721.14 PIK56531.1 - 0.0064 17.0 5.1 23 6.0 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56531.1 - 0.07 13.8 3.5 3.4 8.4 0.2 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK56531.1 - 0.089 13.2 1.5 44 4.8 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK56531.1 - 0.099 12.7 2.1 13 5.9 0.1 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK56531.1 - 0.12 12.4 5.0 1.1 9.3 0.5 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 5 DUF5113 PF17140.4 PIK56531.1 - 0.49 10.2 4.0 1.1 9.0 0.1 3.1 4 1 0 5 5 5 0 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 PIK56531.1 - 3.4 8.0 8.5 14 6.0 1.1 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 PIK56532.1 - 3.9e-52 174.4 29.6 3.3e-12 46.5 1.3 6.1 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56532.1 - 2.8e-50 164.7 30.0 4.9e-07 29.3 0.2 10.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56532.1 - 3.8e-43 143.6 35.4 8.7e-05 22.2 1.8 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56532.1 - 2.9e-30 103.2 24.9 0.0011 18.8 0.1 10.0 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56532.1 - 1.3e-27 93.7 36.4 2.1e-05 24.2 1.4 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56532.1 - 2.1e-27 93.0 34.0 0.00012 22.0 0.1 10.4 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_4 PF07721.14 PIK56532.1 - 3.6e-12 45.7 0.0 0.22 12.2 0.0 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56532.1 - 7e-11 42.0 11.6 0.26 12.2 0.1 8.7 10 0 0 10 10 9 2 Tetratricopeptide repeat Rapsyn_N PF10579.9 PIK56532.1 - 5.6e-10 39.2 13.0 0.024 14.7 0.0 7.1 4 3 3 7 7 7 3 Rapsyn N-terminal myristoylation and linker region TPR_17 PF13431.6 PIK56532.1 - 1.1e-09 38.0 14.7 0.28 11.6 0.1 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK56532.1 - 2.1e-07 30.6 11.5 5.6e-05 22.7 0.3 2.6 1 1 1 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 PIK56532.1 - 1.8e-06 28.2 15.6 0.63 10.8 0.1 7.7 8 1 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56532.1 - 4e-06 27.4 8.9 0.24 12.1 0.2 6.1 5 2 1 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56532.1 - 0.00016 22.1 10.9 1.4 9.5 1.1 5.2 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK56532.1 - 0.0017 18.4 2.0 13 6.0 0.0 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF2989 PF11207.8 PIK56532.1 - 0.0048 16.7 1.4 0.18 11.6 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2989) RPN7 PF10602.9 PIK56532.1 - 0.013 15.2 10.6 1.2 8.8 0.2 4.6 4 1 1 5 5 5 0 26S proteasome subunit RPN7 ComR_TPR PF18710.1 PIK56532.1 - 0.041 13.4 1.0 0.091 12.3 0.0 2.0 2 1 0 2 2 2 0 ComR tetratricopeptide Fis1_TPR_C PF14853.6 PIK56532.1 - 0.056 13.5 16.1 6.2 7.0 0.9 6.0 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat Prefoldin PF02996.17 PIK56532.1 - 0.061 13.2 0.0 0.77 9.7 0.0 2.6 2 1 1 3 3 3 0 Prefoldin subunit DUF4807 PF16065.5 PIK56532.1 - 0.089 12.5 4.2 0.79 9.4 0.1 3.8 3 2 0 4 4 4 0 Domain of unknown function (DUF4807) TPR_11 PF13414.6 PIK56532.1 - 0.15 11.8 31.7 6.2 6.6 1.2 8.5 8 3 3 11 11 11 0 TPR repeat TPR_3 PF07720.12 PIK56532.1 - 1 9.4 11.2 3.2 7.8 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK56532.1 - 8 6.6 13.9 12 6.1 0.1 5.0 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 5 CHAT PF12770.7 PIK56533.1 - 1.8e-33 116.2 0.0 3.7e-33 115.2 0.0 1.5 1 0 0 1 1 1 1 CHAT domain TPR_12 PF13424.6 PIK56533.1 - 4e-18 65.5 5.8 3.3e-11 43.3 0.8 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56533.1 - 3.3e-12 45.6 1.2 0.021 15.0 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56533.1 - 3.1e-10 39.4 0.2 0.012 15.4 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56533.1 - 4.2e-10 38.9 1.5 0.0018 18.2 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56533.1 - 2.1e-07 30.5 0.2 0.048 13.8 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56533.1 - 2.7e-07 30.2 0.9 0.16 11.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56533.1 - 2e-06 28.2 0.7 0.19 12.6 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK56533.1 - 0.0006 19.3 4.6 0.0034 16.8 4.5 2.0 1 1 0 1 1 1 1 MalT-like TPR region Wzy_C_2 PF11846.8 PIK56533.1 - 0.018 15.0 0.4 0.16 11.9 0.0 2.5 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_6 PF13174.6 PIK56533.1 - 0.027 15.1 0.2 35 5.3 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56533.1 - 0.041 14.5 1.5 5.5 7.7 0.1 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK56533.1 - 0.052 14.2 0.4 5.5 7.9 0.2 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56533.1 - 0.1 12.3 0.1 2.6 7.8 0.0 3.2 2 1 1 3 3 3 0 TPR repeat CHAT PF12770.7 PIK56534.1 - 7.9e-05 22.2 0.0 0.00018 21.0 0.0 1.6 2 0 0 2 2 2 1 CHAT domain PUB PF09409.10 PIK56534.1 - 0.033 14.1 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 PUB domain Lipase_GDSL_2 PF13472.6 PIK56536.1 - 1.5e-06 28.8 0.0 4.9e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family MFS_1 PF07690.16 PIK56538.1 - 2e-18 66.5 13.4 2.3e-16 59.7 3.4 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily 2TM PF13239.6 PIK56538.1 - 7.8 6.9 9.4 0.5 10.7 0.4 3.4 3 1 0 3 3 3 0 2TM domain SSrecog PF03531.14 PIK56541.1 - 4.4e-26 90.6 0.0 1.1e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 PIK56541.1 - 4.5e-19 68.7 0.5 1.5e-18 66.9 0.2 2.1 2 0 0 2 2 2 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 PIK56541.1 - 3.5e-18 65.8 0.1 1.4e-17 63.8 0.0 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Fibrinogen_C PF00147.18 PIK56542.1 - 3.8e-46 157.6 9.3 4.5e-45 154.1 9.3 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF3943 PF13084.6 PIK56542.1 - 0.72 9.7 2.5 43 4.0 0.1 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3943) SPT2 PF08243.11 PIK56543.1 - 0.3 11.6 1.7 1.4 9.5 0.2 2.3 2 0 0 2 2 2 0 SPT2 chromatin protein V-set PF07686.17 PIK56544.1 - 4.9e-07 29.9 0.3 0.054 13.7 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK56544.1 - 9.5e-05 22.4 0.5 0.1 12.7 0.2 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK56544.1 - 0.0018 18.4 0.3 1.3 9.2 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK56544.1 - 0.0028 18.2 2.1 1.7 9.3 0.0 3.7 4 1 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK56544.1 - 0.086 13.2 0.4 3.7 8.0 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain ApoL PF05461.11 PIK56544.1 - 0.11 11.9 0.0 0.63 9.3 0.0 2.0 2 0 0 2 2 2 0 Apolipoprotein L Na_sulph_symp PF00939.19 PIK56545.1 - 1.2e-87 295.0 21.0 1.5e-87 294.6 21.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK56545.1 - 9.2e-32 110.4 34.8 1.8e-18 66.8 9.7 3.3 2 1 1 3 3 3 3 Citrate transporter I-set PF07679.16 PIK56546.1 - 0.0041 17.2 0.0 0.69 10.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK56546.1 - 0.039 14.5 0.2 7.6 7.2 0.1 2.7 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK56546.1 - 0.047 13.8 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Invasin_D3 PF09134.10 PIK56546.1 - 0.18 12.1 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Invasin, domain 3 UCH PF00443.29 PIK56547.1 - 3.6e-15 56.2 0.1 5.8e-15 55.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK56547.1 - 6.4e-08 32.5 0.1 8.7e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ig_3 PF13927.6 PIK56548.1 - 4.5e-09 36.8 2.0 2.1e-05 25.1 0.4 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK56548.1 - 8e-07 29.0 0.2 0.0015 18.6 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK56548.1 - 4e-05 23.7 2.0 0.0056 16.8 0.3 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK56548.1 - 0.00014 22.1 8.1 0.00016 22.0 2.1 2.8 2 2 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK56548.1 - 0.00089 19.3 0.0 0.0034 17.4 0.0 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK56548.1 - 0.0025 17.8 0.1 0.0058 16.7 0.1 1.6 1 1 0 1 1 1 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK56548.1 - 0.0025 18.1 1.2 0.025 14.9 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.17 PIK56548.1 - 0.031 14.4 1.9 0.38 10.9 0.8 2.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain MPC PF03650.13 PIK56548.1 - 0.098 12.8 0.8 0.41 10.8 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial pyruvate carriers Ig_6 PF18452.1 PIK56548.1 - 0.1 12.2 0.9 0.69 9.5 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain DUF4988 PF16378.5 PIK56548.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function Pkinase_Tyr PF07714.17 PIK56549.1 - 0.1 11.8 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase SRCR PF00530.18 PIK56550.1 - 9.4e-12 45.3 0.0 1.2e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK56550.1 - 0.025 15.1 0.0 0.051 14.1 0.0 1.4 1 1 0 1 1 1 0 Scavenger receptor cysteine-rich domain RVT_1 PF00078.27 PIK56552.1 - 6.6e-10 38.9 0.0 1.2e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK56553.1 - 2.1e-37 127.2 0.0 4.1e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56553.1 - 1.6e-35 121.6 0.0 3.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56553.1 - 2.5e-27 95.8 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK56554.1 - 3.6e-17 62.7 0.0 7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56554.1 - 2.1e-08 34.1 0.6 5.1e-08 32.9 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK56554.1 - 0.002 17.8 0.1 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK56554.1 - 0.06 13.4 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 Exo_endo_phos_2 PF14529.6 PIK56555.1 - 9.8e-06 25.4 0.2 0.00028 20.7 0.1 2.3 1 1 1 2 2 2 1 Endonuclease-reverse transcriptase T4-Gluco-transf PF09198.10 PIK56555.1 - 0.098 12.3 0.2 0.098 12.3 0.2 1.8 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase Peptidase_A17 PF05380.13 PIK56556.1 - 9.5e-53 178.5 0.0 1.6e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK56556.1 - 0.00062 19.8 1.7 0.0019 18.2 1.7 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK56556.1 - 0.0043 17.3 0.0 0.0093 16.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK56556.1 - 0.029 14.4 0.0 0.079 13.0 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56556.1 - 0.042 13.4 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK56556.1 - 0.078 13.2 1.4 0.15 12.3 0.9 1.8 1 1 0 1 1 1 0 H2C2 zinc finger UBA_6 PF18039.1 PIK56559.1 - 0.14 12.1 0.1 0.33 10.9 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain PARP_reg PF02877.14 PIK56560.1 - 1.7e-38 131.8 0.7 1.7e-38 131.8 0.7 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain PARP PF00644.20 PIK56560.1 - 1.7e-36 125.6 0.0 1.7e-36 125.6 0.0 2.7 3 1 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 PIK56560.1 - 4.9e-28 97.0 1.8 4.9e-28 97.0 1.8 2.2 2 0 0 2 2 2 1 WGR domain RF-1 PF00472.20 PIK56560.1 - 0.099 12.6 0.8 0.47 10.4 0.2 2.4 1 1 1 2 2 2 0 RF-1 domain RT_RNaseH_2 PF17919.1 PIK56562.1 - 1.4e-36 124.5 0.0 2.9e-36 123.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56562.1 - 2.2e-35 121.1 0.0 4.3e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK56562.1 - 1.8e-21 76.7 0.0 4e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK56562.1 - 0.0011 19.3 0.0 0.0024 18.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK56562.1 - 0.0017 18.4 15.6 0.018 15.1 3.6 2.7 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 PIK56562.1 - 0.024 15.2 0.0 0.068 13.7 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK56562.1 - 0.029 15.0 0.0 0.084 13.5 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease DNA_pol_viral_C PF00336.18 PIK56562.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Phage_integrase PF00589.22 PIK56563.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family TPMT PF05724.11 PIK56564.1 - 0.066 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Sulfatase PF00884.23 PIK56566.1 - 3.1e-50 171.3 0.2 5.5e-47 160.7 0.2 2.2 2 0 0 2 2 2 2 Sulfatase Phosphodiest PF01663.22 PIK56566.1 - 4.6e-07 29.7 0.0 0.0017 18.1 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 PIK56566.1 - 0.00025 19.8 0.0 0.00045 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 PIK56566.1 - 0.0004 20.6 0.1 0.0004 20.6 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Exo_endo_phos_2 PF14529.6 PIK56567.1 - 0.00013 21.8 0.1 0.00026 20.8 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Ig_C17orf99 PF17736.1 PIK56567.1 - 0.047 13.7 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 C17orf99 Ig domain Ribosomal_S27e PF01667.17 PIK56568.1 - 0.12 12.1 1.3 3.7 7.3 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 SRCR PF00530.18 PIK56571.1 - 1.9e-21 76.4 3.3 1.9e-21 76.4 3.3 2.3 3 0 0 3 3 3 1 Scavenger receptor cysteine-rich domain CUB PF00431.20 PIK56571.1 - 1.5e-07 31.8 0.0 1e-06 29.1 0.0 2.6 1 1 0 1 1 1 1 CUB domain Sushi PF00084.20 PIK56571.1 - 1.4e-06 28.8 0.9 1.4e-06 28.8 0.9 2.4 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) WSC PF01822.19 PIK56571.1 - 2.8e-05 24.2 1.0 2.8e-05 24.2 1.0 2.1 2 0 0 2 2 2 1 WSC domain SRCR_2 PF15494.6 PIK56571.1 - 0.00027 21.4 0.9 0.00027 21.4 0.9 2.1 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain RVT_1 PF00078.27 PIK56572.1 - 7.5e-47 159.7 0.2 8.8e-47 159.5 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAIM1 PF06905.13 PIK56572.1 - 0.073 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Fas apoptotic inhibitory molecule (FAIM1) Thiamine_BP PF01910.17 PIK56572.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Thiamine-binding protein DDE_Tnp_4 PF13359.6 PIK56573.1 - 1.5e-45 154.7 0.0 2e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.6 PIK56573.1 - 1.2e-09 37.8 0.2 2.1e-09 37.0 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 PIK56573.1 - 2.2e-05 24.2 0.0 5.6e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Transposase DDE domain Sulfatase PF00884.23 PIK56574.1 - 7.8e-25 87.9 0.0 1.1e-24 87.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF4994 PF16385.5 PIK56574.1 - 0.008 16.1 0.4 0.3 11.0 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function Sulfatase_C PF14707.6 PIK56574.1 - 0.022 15.5 0.5 0.07 13.9 0.0 2.1 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 PIK56574.1 - 0.057 13.0 0.0 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Hexokinase_2 PF03727.16 PIK56575.1 - 2.1e-83 279.4 0.0 2.8e-83 279.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 PIK56575.1 - 7.2e-47 159.9 0.0 1.6e-46 158.8 0.0 1.5 1 0 0 1 1 1 1 Hexokinase SSF PF00474.17 PIK56576.1 - 2.8e-24 85.8 17.8 6.2e-24 84.6 17.8 1.5 1 1 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK56577.1 - 1.1e-06 27.8 2.8 1.4e-06 27.5 2.8 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Snf7 PF03357.21 PIK56578.1 - 6.8e-18 64.9 9.6 1.4e-17 63.9 9.6 1.5 1 0 0 1 1 1 1 Snf7 Tropomyosin_1 PF12718.7 PIK56578.1 - 0.00071 19.8 6.3 0.0014 18.8 6.3 1.5 1 0 0 1 1 1 1 Tropomyosin like T4SS PF07996.11 PIK56578.1 - 0.015 15.8 2.5 0.034 14.6 2.5 1.6 1 0 0 1 1 1 0 Type IV secretion system proteins ESCRT-II PF05871.12 PIK56578.1 - 0.025 14.9 2.1 0.26 11.5 0.1 2.5 2 0 0 2 2 2 0 ESCRT-II complex subunit DUF4407 PF14362.6 PIK56578.1 - 0.063 12.6 2.8 0.087 12.2 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FIVAR PF07554.13 PIK56578.1 - 0.19 12.5 4.0 0.61 10.9 0.4 2.6 1 1 1 2 2 2 0 FIVAR domain DWNN PF08783.11 PIK56578.1 - 0.25 11.6 1.3 0.69 10.3 0.1 2.2 2 0 0 2 2 2 0 DWNN domain RGS PF00615.19 PIK56578.1 - 1.9 8.8 4.9 22 5.4 0.1 3.3 2 2 0 2 2 2 0 Regulator of G protein signaling domain FlaC_arch PF05377.11 PIK56578.1 - 2 8.9 5.8 53 4.3 0.4 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) LSM PF01423.22 PIK56579.1 - 2.3e-13 49.6 4.4 8.2e-12 44.6 0.3 2.6 2 1 0 2 2 2 2 LSM domain F-box-like PF12937.7 PIK56580.1 - 4.7e-10 39.2 0.3 1e-09 38.1 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK56580.1 - 5.1e-07 29.4 0.4 5.1e-07 29.4 0.4 2.1 2 0 0 2 2 2 1 F-box domain WD40 PF00400.32 PIK56580.1 - 5.2e-06 27.1 5.1 4.8 8.2 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat F-box_4 PF15966.5 PIK56580.1 - 0.00014 21.7 0.1 0.00036 20.4 0.1 1.7 1 0 0 1 1 1 1 F-box PRANC PF09372.10 PIK56580.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 PRANC domain Aldo_ket_red PF00248.21 PIK56581.1 - 4.3e-53 180.4 0.0 6.4e-53 179.9 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family Arf PF00025.21 PIK56582.1 - 9e-65 217.4 0.0 1e-64 217.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK56582.1 - 4.8e-13 49.0 0.0 6e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 PIK56582.1 - 5.9e-13 48.7 0.2 1.9e-08 33.9 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 PIK56582.1 - 8.5e-13 48.6 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK56582.1 - 1.2e-10 41.1 0.0 1.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK56582.1 - 3.7e-10 39.6 0.0 4.2e-10 39.4 0.0 1.0 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 PIK56582.1 - 3e-09 36.9 0.0 4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK56582.1 - 0.0025 17.4 0.0 0.023 14.2 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 PIK56582.1 - 0.0075 15.8 0.8 0.039 13.5 0.8 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 PIK56582.1 - 0.031 14.7 0.0 0.045 14.2 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 PIK56582.1 - 0.034 14.7 0.0 0.067 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK56582.1 - 0.037 14.5 0.1 0.047 14.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 PIK56582.1 - 0.046 13.5 0.1 0.079 12.7 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 PIK56582.1 - 0.079 12.9 0.0 13 5.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DLIC PF05783.11 PIK56582.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.4 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) Vinculin PF01044.19 PIK56583.1 - 1.1e-44 153.0 47.0 5.6e-18 64.6 4.2 6.3 2 2 4 6 6 6 6 Vinculin family I_LWEQ PF01608.17 PIK56583.1 - 0.00052 20.3 1.0 0.00052 20.3 1.0 5.4 6 0 0 6 6 6 1 I/LWEQ domain Sulfotransfer_3 PF13469.6 PIK56583.1 - 0.075 13.4 0.0 2.5 8.4 0.0 3.0 2 0 0 2 2 2 0 Sulfotransferase family CdiA_C_tRNase PF18664.1 PIK56583.1 - 0.11 12.7 0.1 2e+02 2.2 0.0 4.2 1 1 3 4 4 4 0 CdiA C-terminal tRNase domain Focal_AT PF03623.13 PIK56583.1 - 0.14 12.2 7.9 1.2 9.1 1.2 4.8 4 1 0 4 4 4 0 Focal adhesion targeting region HSP70 PF00012.20 PIK56584.1 - 0.0014 16.9 0.0 0.012 13.8 0.0 2.0 2 0 0 2 2 2 1 Hsp70 protein Rot1 PF10681.9 PIK56584.1 - 0.16 11.4 0.8 0.89 9.0 0.0 2.4 3 0 0 3 3 3 0 Chaperone for protein-folding within the ER, fungal PLA1 PF02253.15 PIK56585.1 - 0.19 11.3 0.3 2.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Phospholipase A1 Glutaredoxin PF00462.24 PIK56586.1 - 2.8e-37 126.8 0.0 2.1e-17 63.1 0.0 3.3 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 PIK56586.1 - 2.1e-13 50.1 0.1 8.3e-13 48.2 0.1 2.0 2 0 0 2 2 2 1 Thioredoxin SH3BGR PF04908.15 PIK56586.1 - 1.3e-09 38.1 0.0 8.4e-05 22.7 0.0 2.8 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein HyaE PF07449.11 PIK56586.1 - 8.7e-05 22.4 0.1 0.0018 18.2 0.1 2.8 3 1 0 3 3 3 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 PIK56586.1 - 0.00018 21.5 0.7 0.00097 19.1 0.3 2.3 3 0 0 3 3 3 1 Thioredoxin domain GST_N_3 PF13417.6 PIK56586.1 - 0.00022 21.6 0.0 0.023 15.1 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 PIK56586.1 - 0.00057 20.3 0.1 0.0046 17.4 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK56586.1 - 0.0011 19.3 0.3 0.12 12.7 0.1 2.7 1 1 1 2 2 2 1 Thioredoxin-like TraF PF13728.6 PIK56586.1 - 0.038 13.8 0.1 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein TrbC_Ftype PF09673.10 PIK56586.1 - 0.079 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein TRC8_N PF13705.6 PIK56587.1 - 3.4e-114 382.5 39.8 4.2e-114 382.2 39.8 1.1 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-C3HC4_2 PF13923.6 PIK56587.1 - 1.2e-07 31.4 11.1 3.6e-07 29.9 11.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK56587.1 - 1.4e-07 31.7 11.9 1.4e-07 31.7 11.9 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 PIK56587.1 - 7.3e-07 29.4 12.1 4.4e-06 26.9 12.1 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 PIK56587.1 - 9.2e-06 25.4 8.9 9.2e-06 25.4 8.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK56587.1 - 3.8e-05 23.6 7.0 0.0001 22.2 7.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK56587.1 - 4.3e-05 23.3 11.6 4.3e-05 23.3 11.6 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK56587.1 - 7e-05 22.6 7.2 7e-05 22.6 7.2 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK56587.1 - 0.006 16.3 8.2 0.019 14.7 8.2 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 PIK56587.1 - 0.01 15.8 11.3 0.01 15.8 11.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 PIK56587.1 - 0.034 14.2 8.7 0.22 11.6 8.7 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 PIK56587.1 - 0.17 12.0 4.6 0.44 10.7 4.6 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 PIK56587.1 - 0.45 10.2 9.1 1.6 8.4 9.1 2.0 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 PIK56587.1 - 1 9.6 9.7 2.5 8.3 9.7 1.7 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 PIK56587.1 - 7 6.9 9.6 55 4.0 9.6 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain SLD5_C PF16922.5 PIK56588.1 - 2.2e-14 53.4 0.1 2.2e-14 53.4 0.1 2.2 2 0 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 PIK56588.1 - 0.072 13.6 5.2 0.17 12.4 5.1 1.8 1 1 1 2 2 2 0 GINS complex protein Ndr PF03096.14 PIK56589.1 - 1.4e-77 260.2 0.1 1.8e-77 259.8 0.1 1.0 1 0 0 1 1 1 1 Ndr family GerE PF00196.19 PIK56589.1 - 0.032 13.8 0.0 0.086 12.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Sulfatase PF00884.23 PIK56590.1 - 9.3e-50 169.8 0.0 2.9e-49 168.1 0.0 1.7 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 PIK56590.1 - 1.1e-09 38.5 1.0 5.5e-08 33.0 1.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 PIK56590.1 - 2.1e-08 34.1 0.0 7.4e-07 29.1 0.0 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 PIK56590.1 - 0.074 13.8 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 PIK56590.1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF1501 PF07394.12 PIK56590.1 - 0.2 10.7 0.0 0.45 9.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Acyltransferase PF01553.21 PIK56591.1 - 4.9e-18 65.0 0.0 1.1e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase FAM124 PF15067.6 PIK56592.1 - 8.7e-57 192.4 0.1 1e-56 192.2 0.1 1.0 1 0 0 1 1 1 1 FAM124 family DrrA_P4M PF14860.6 PIK56593.1 - 0.00075 19.3 0.1 1.3 8.9 0.2 2.6 2 0 0 2 2 2 2 DrrA phosphatidylinositol 4-phosphate binding domain INO80_Ies4 PF08193.11 PIK56594.1 - 0.56 10.2 6.7 0.99 9.3 6.7 1.4 1 0 0 1 1 1 0 INO80 complex subunit Ies4 EXOSC1 PF10447.9 PIK56595.1 - 1.1e-14 55.0 0.1 1.7e-14 54.4 0.1 1.3 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 PIK56595.1 - 1.3e-11 44.1 0.1 2.8e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region FAM184 PF15665.5 PIK56596.1 - 0.0025 17.6 19.0 0.0025 17.6 19.0 2.4 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B Thioredoxin_16 PF18569.1 PIK56596.1 - 0.024 14.7 0.2 0.059 13.5 0.2 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain DUF4407 PF14362.6 PIK56596.1 - 6.7 6.0 28.9 11 5.3 28.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ig PF00047.25 PIK56597.1 - 1.3e-05 25.3 0.4 7.4e-05 22.8 0.4 2.2 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK56597.1 - 1.5e-05 25.2 3.0 1.9e-05 24.8 0.7 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK56597.1 - 0.0008 20.0 0.1 0.0026 18.3 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK56597.1 - 0.016 15.5 2.1 0.027 14.8 0.2 2.3 2 1 0 2 2 2 0 Immunoglobulin domain Izumo-Ig PF16706.5 PIK56597.1 - 0.11 12.5 0.2 0.97 9.5 0.2 2.4 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain RVT_1 PF00078.27 PIK56598.1 - 1.1e-25 90.5 0.0 1.4e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.17 PIK56599.1 - 1.7e-36 125.9 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56599.1 - 3.5e-21 75.8 0.0 5.7e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK56599.1 - 0.00012 21.6 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like I-set PF07679.16 PIK56599.1 - 0.036 14.1 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF4711 PF15829.5 PIK56599.1 - 0.042 13.8 0.2 0.085 12.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Ion_trans PF00520.31 PIK56599.1 - 0.054 12.7 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Ion transport protein DUF4083 PF13314.6 PIK56599.1 - 0.39 10.7 2.8 1.2 9.1 2.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) zf-B_box PF00643.24 PIK56600.1 - 9.6e-08 32.1 6.6 9.6e-08 32.1 6.6 3.4 4 1 0 4 4 2 1 B-box zinc finger zf-RING_5 PF14634.6 PIK56600.1 - 0.00031 20.6 22.0 0.00051 19.9 9.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK56600.1 - 0.00065 19.5 8.0 0.00065 19.5 8.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK56600.1 - 0.0029 17.4 11.4 0.0029 17.4 11.4 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK56600.1 - 0.007 16.7 10.4 0.007 16.7 10.4 2.9 2 0 0 2 2 2 1 Ring finger domain STAT_alpha PF01017.20 PIK56600.1 - 0.1 12.5 6.7 0.18 11.7 6.7 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain HSBP1 PF06825.12 PIK56600.1 - 0.15 11.9 0.6 0.53 10.2 0.2 2.0 3 0 0 3 3 2 0 Heat shock factor binding protein 1 GPS2_interact PF15784.5 PIK56600.1 - 0.18 12.3 3.0 0.15 12.5 1.2 1.8 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain AIP3 PF03915.13 PIK56600.1 - 0.2 10.7 8.0 0.32 10.1 8.0 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Sec8_exocyst PF04048.14 PIK56600.1 - 0.49 10.3 4.7 0.24 11.3 1.9 1.9 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Prok-RING_4 PF14447.6 PIK56600.1 - 1.3 8.9 19.4 0.077 12.9 7.8 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 FYVE PF01363.21 PIK56600.1 - 1.6 8.9 14.4 0.83 9.8 3.8 2.8 1 1 1 2 2 2 0 FYVE zinc finger Spc7 PF08317.11 PIK56600.1 - 2.6 6.8 14.8 6.9 5.5 14.8 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein zf-RING_10 PF16685.5 PIK56600.1 - 2.7 8.2 19.2 0.83 9.8 7.9 3.4 3 0 0 3 3 3 0 zinc RING finger of MSL2 zf-C3HC4_2 PF13923.6 PIK56600.1 - 2.7 7.9 23.4 0.55 10.1 10.4 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Exonuc_VII_L PF02601.15 PIK56600.1 - 4.3 6.8 6.8 6.3 6.3 6.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Occludin_ELL PF07303.13 PIK56600.1 - 5.6 7.8 6.2 2.8 8.7 2.1 2.2 1 1 1 2 2 2 0 Occludin homology domain I-set PF07679.16 PIK56601.1 - 1.6e-89 294.1 4.9 4.3e-18 65.2 0.0 8.1 6 1 2 8 8 8 8 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK56601.1 - 1.7e-83 275.3 27.2 2.6e-16 60.0 0.1 8.2 8 0 0 8 8 8 8 Immunoglobulin domain Ig_2 PF13895.6 PIK56601.1 - 3.5e-63 209.9 24.4 3.2e-12 46.6 0.1 8.2 6 1 2 8 8 8 8 Immunoglobulin domain ig PF00047.25 PIK56601.1 - 2.9e-56 187.6 24.4 3.7e-13 49.5 0.2 8.5 6 2 2 8 8 8 8 Immunoglobulin domain V-set PF07686.17 PIK56601.1 - 6.6e-34 116.4 24.7 0.00013 22.1 0.9 11.4 6 5 4 10 10 10 8 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56601.1 - 3.3e-20 71.4 0.6 0.077 12.6 0.0 8.3 6 1 2 8 8 8 4 Immunoglobulin domain Ig_5 PF16681.5 PIK56601.1 - 1.4e-14 54.2 7.1 0.0069 16.8 0.0 7.2 6 1 2 8 8 8 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK56601.1 - 8.5e-13 48.4 6.8 0.0097 16.1 0.0 7.2 6 1 2 8 8 8 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK56601.1 - 7.5e-12 45.2 12.5 0.055 13.5 0.1 6.5 6 1 0 6 6 6 4 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 PIK56601.1 - 1.2e-11 44.5 4.1 0.001 19.1 0.0 6.6 5 1 2 7 7 7 2 C17orf99 Ig domain Izumo-Ig PF16706.5 PIK56601.1 - 1.4e-06 28.2 4.0 4.4 7.4 0.0 7.7 6 1 2 8 8 8 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK56601.1 - 0.00015 21.4 11.9 1.1 9.1 0.0 6.9 6 2 1 7 7 7 2 Adenovirus E3 region protein CR1 C2-set PF05790.15 PIK56601.1 - 0.0022 18.1 3.8 1.7 8.9 0.1 5.8 7 0 0 7 7 5 1 Immunoglobulin C2-set domain Lep_receptor_Ig PF06328.11 PIK56601.1 - 0.0073 16.2 0.1 0.043 13.8 0.1 2.4 1 0 0 1 1 1 1 Ig-like C2-type domain TrkA_C PF02080.21 PIK56601.1 - 0.032 14.0 0.0 3.6 7.5 0.1 2.7 2 0 0 2 2 2 0 TrkA-C domain fn3 PF00041.21 PIK56602.1 - 3.7e-26 91.3 0.9 1.3e-11 44.6 0.4 3.6 3 0 0 3 3 3 3 Fibronectin type III domain Ig_3 PF13927.6 PIK56602.1 - 1.4e-25 89.7 0.9 1.7e-10 41.3 0.0 4.4 4 1 0 4 4 3 3 Immunoglobulin domain I-set PF07679.16 PIK56602.1 - 4.4e-22 77.9 0.0 2.4e-08 33.9 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.25 PIK56602.1 - 8.4e-15 54.7 0.0 1.6e-07 31.4 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK56602.1 - 1.3e-10 41.5 0.1 0.01 16.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK56602.1 - 2.4e-05 24.3 0.4 1.4 9.0 0.0 3.9 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK56602.1 - 0.00064 19.9 0.0 0.027 14.6 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain DUF2207 PF09972.9 PIK56602.1 - 0.012 14.4 0.2 0.012 14.4 0.2 2.4 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF3992 PF13157.6 PIK56602.1 - 0.018 15.8 1.9 0.2 12.4 0.1 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF3992) Pur_ac_phosph_N PF16656.5 PIK56602.1 - 0.026 15.1 4.9 0.22 12.1 0.0 4.0 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain EphA2_TM PF14575.6 PIK56602.1 - 0.028 15.3 0.3 0.39 11.6 0.0 2.5 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 PIK56602.1 - 0.19 10.5 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 Amnionless Protocadherin PF08374.11 PIK56602.1 - 0.26 11.2 6.2 0.52 10.3 0.0 3.1 3 0 0 3 3 3 0 Protocadherin Coilin_N PF15862.5 PIK56602.1 - 0.29 10.9 6.6 0.6 9.9 1.6 2.5 2 0 0 2 2 2 0 Coilin N-terminus Thg1C PF14413.6 PIK56602.1 - 0.76 9.9 3.6 0.66 10.1 0.3 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain Peptidase_S49_N PF08496.10 PIK56602.1 - 2 8.5 7.7 8.9 6.4 3.1 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ufd2P_core PF10408.9 PIK56603.1 - 2.5e-157 525.2 8.6 4e-157 524.6 8.6 1.3 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 PIK56603.1 - 1.1e-26 92.7 0.9 4.1e-26 90.9 0.9 2.1 1 0 0 1 1 1 1 U-box domain DUF445 PF04286.12 PIK56603.1 - 0.088 12.6 1.8 0.16 11.7 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF445) NACHT PF05729.12 PIK56604.1 - 8.8e-09 35.5 0.0 2e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 PIK56604.1 - 0.0013 18.3 0.0 0.0037 16.8 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region DUF2207 PF09972.9 PIK56604.1 - 0.002 17.0 0.2 0.0059 15.4 0.1 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) AAA_16 PF13191.6 PIK56604.1 - 0.0032 17.9 0.0 0.0055 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 PIK56604.1 - 0.004 16.9 0.0 0.0076 16.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 PIK56604.1 - 0.019 14.1 0.0 0.044 12.8 0.0 1.5 1 1 1 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 PIK56604.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.22 PIK56604.1 - 0.028 14.8 0.1 0.066 13.6 0.1 1.7 1 1 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 PIK56604.1 - 0.028 14.7 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain InaF-motif PF15018.6 PIK56604.1 - 0.03 14.2 1.1 0.03 14.2 1.1 1.9 2 0 0 2 2 2 0 TRP-interacting helix DUF815 PF05673.13 PIK56604.1 - 0.048 12.8 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 PIK56604.1 - 0.073 13.6 0.1 0.13 12.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter Ras PF00071.22 PIK56604.1 - 0.11 12.0 0.1 0.24 11.0 0.1 1.6 1 1 0 1 1 1 0 Ras family Roc PF08477.13 PIK56604.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 PIK56604.1 - 0.13 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK56604.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF4897 PF16238.5 PIK56605.1 - 0.0018 18.1 0.5 0.0035 17.2 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4897) Pkinase_Tyr PF07714.17 PIK56606.1 - 3e-33 115.2 0.1 3.8e-33 114.9 0.1 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56606.1 - 4.3e-10 39.4 0.0 5.7e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain NACHT PF05729.12 PIK56607.1 - 2e-10 40.9 0.0 4.2e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 PIK56607.1 - 0.0008 19.8 0.0 0.0025 18.2 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK56607.1 - 0.0015 18.9 0.0 0.0038 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK56607.1 - 0.0028 16.9 2.3 0.098 11.8 2.3 2.6 1 1 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 PIK56607.1 - 0.0082 16.7 2.1 0.13 12.8 2.1 2.9 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 PIK56607.1 - 0.014 15.3 0.0 0.05 13.5 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 PIK56607.1 - 0.014 15.2 0.1 0.13 12.0 0.0 2.4 1 1 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 PIK56607.1 - 0.021 15.1 0.1 0.083 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK56607.1 - 0.069 13.3 0.3 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK56607.1 - 0.073 12.6 0.0 0.96 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 PIK56607.1 - 0.074 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_5 PF07728.14 PIK56607.1 - 0.074 13.0 0.2 0.55 10.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 PIK56607.1 - 0.12 12.7 0.2 0.73 10.2 0.0 2.3 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 PIK56607.1 - 0.12 12.5 0.1 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 PIK56608.1 - 2.8e-10 40.3 0.1 7.7e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 NACHT domain MMR_HSR1 PF01926.23 PIK56608.1 - 0.0029 17.7 0.0 0.7 10.0 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK56608.1 - 0.0065 16.9 0.0 0.033 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 PIK56608.1 - 0.03 14.8 0.0 0.073 13.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 PIK56608.1 - 0.048 14.2 0.1 0.11 13.1 0.1 1.8 1 1 0 1 1 1 0 ABC transporter DUF1086 PF06461.11 PIK56608.1 - 0.078 12.8 1.1 0.15 11.9 0.2 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1086) TCTP PF00838.17 PIK56611.1 - 0.036 14.4 4.0 0.043 14.2 0.0 2.5 2 1 0 2 2 2 0 Translationally controlled tumour protein APP_E2 PF12925.7 PIK56611.1 - 0.096 12.4 0.6 3.2 7.4 0.2 2.3 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Tnp_P_element PF12017.8 PIK56612.1 - 2.3e-16 59.9 0.0 3.4e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Transposase protein Spc29 PF17082.5 PIK56612.1 - 0.031 14.1 0.2 0.053 13.4 0.2 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF3847 PF12958.7 PIK56612.1 - 0.054 13.6 0.6 0.12 12.5 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) CHD5 PF04420.14 PIK56612.1 - 0.067 13.0 3.5 0.13 12.1 3.5 1.4 1 0 0 1 1 1 0 CHD5-like protein dCache_2 PF08269.11 PIK56612.1 - 0.098 11.8 0.8 0.16 11.2 0.8 1.3 1 0 0 1 1 1 0 Cache domain Gcd10p PF04189.13 PIK56612.1 - 0.11 11.6 4.0 0.076 12.1 0.8 2.0 2 0 0 2 2 2 0 Gcd10p family Syntaxin_2 PF14523.6 PIK56612.1 - 0.72 10.3 5.4 1.4 9.3 5.4 1.5 1 0 0 1 1 1 0 Syntaxin-like protein DUF5093 PF17011.5 PIK56614.1 - 0.048 13.9 0.5 0.048 13.9 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) YaeQ PF07152.12 PIK56614.1 - 0.13 11.9 0.1 0.37 10.4 0.1 1.7 2 0 0 2 2 2 0 YaeQ protein NACHT PF05729.12 PIK56615.1 - 1.9e-10 40.9 0.0 4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK56615.1 - 2.2e-05 24.9 0.0 0.00012 22.5 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK56615.1 - 6.1e-05 22.3 0.3 0.00025 20.3 0.2 2.1 1 1 0 1 1 1 1 NB-ARC domain MMR_HSR1 PF01926.23 PIK56615.1 - 0.0028 17.7 0.0 0.42 10.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 PIK56615.1 - 0.011 16.2 0.1 0.032 14.7 0.0 1.9 1 1 0 1 1 1 0 ABC transporter DUF815 PF05673.13 PIK56615.1 - 0.012 14.8 0.0 0.054 12.6 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 PIK56615.1 - 0.018 14.6 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 PIK56615.1 - 0.019 15.4 0.0 0.047 14.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK56615.1 - 0.034 14.4 0.0 0.3 11.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 PIK56615.1 - 0.079 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 PIK56615.1 - 0.089 12.5 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein PI3K_rbd PF00794.18 PIK56616.1 - 0.076 13.2 0.0 0.099 12.8 0.0 1.2 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain V-set PF07686.17 PIK56617.1 - 1.5e-09 37.9 0.3 5e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK56617.1 - 3e-07 30.9 2.0 0.0011 19.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK56617.1 - 5.2e-07 29.8 0.3 0.00012 22.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK56617.1 - 7.4e-07 29.1 0.3 0.00054 20.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK56617.1 - 0.0022 18.3 2.5 0.96 9.8 0.2 2.4 1 1 1 2 2 2 2 Immunoglobulin domain DUF1533 PF07550.11 PIK56617.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) ComR_TPR PF18710.1 PIK56618.1 - 0.059 12.9 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 ComR tetratricopeptide V-set PF07686.17 PIK56619.1 - 8.2e-07 29.2 0.0 3.4e-06 27.2 0.0 2.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK56619.1 - 3.8e-06 26.9 0.1 1.6e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK56619.1 - 7.2e-06 26.5 0.2 4e-05 24.1 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain NACHT PF05729.12 PIK56619.1 - 0.00066 19.6 0.1 0.0015 18.4 0.1 1.6 1 0 0 1 1 1 1 NACHT domain Protocadherin PF08374.11 PIK56619.1 - 0.00087 19.3 0.1 0.0018 18.3 0.1 1.5 1 0 0 1 1 1 1 Protocadherin ig PF00047.25 PIK56619.1 - 0.001 19.2 0.3 0.0036 17.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain EphA2_TM PF14575.6 PIK56619.1 - 0.025 15.4 0.1 0.09 13.7 0.1 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Lyase_8_C PF02884.17 PIK56619.1 - 0.032 14.7 0.0 3 8.4 0.0 2.8 2 0 0 2 2 2 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain LYRIC PF15686.5 PIK56619.1 - 0.038 13.6 0.4 0.083 12.4 0.4 1.5 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4723 PF15851.5 PIK56619.1 - 0.062 13.4 0.0 11 6.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4723) AAA_19 PF13245.6 PIK56619.1 - 0.077 13.3 0.0 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Myb_DNA-bind_6 PF13921.6 PIK56620.1 - 0.0016 18.6 0.5 0.0025 18.0 0.5 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Med18 PF09637.10 PIK56621.1 - 0.0075 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Med18 protein Nop25 PF09805.9 PIK56622.1 - 0.82 10.1 9.7 3 8.3 2.2 2.2 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DUF2457 PF10446.9 PIK56622.1 - 4.8 6.2 54.9 0.39 9.8 22.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) GCFC PF07842.12 PIK56623.1 - 0.061 12.9 0.0 0.066 12.8 0.0 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein Integrase_H2C2 PF17921.1 PIK56624.1 - 7.3e-09 35.6 0.2 1.6e-08 34.5 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain DNA_pol_viral_C PF00336.18 PIK56624.1 - 0.048 13.1 0.0 0.087 12.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Peptidase_A17 PF05380.13 PIK56625.1 - 7.3e-33 113.9 0.0 1.2e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase Pkinase_Tyr PF07714.17 PIK56626.1 - 1e-32 113.5 0.0 1.4e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56626.1 - 4.1e-08 32.9 0.0 6.9e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain ABC2_membrane_3 PF12698.7 PIK56627.1 - 0.011 14.8 1.9 0.014 14.5 1.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein I-set PF07679.16 PIK56627.1 - 0.11 12.6 0.0 0.96 9.6 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK56627.1 - 0.36 10.9 0.1 0.36 10.9 0.1 3.0 2 2 1 3 3 3 0 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK56628.1 - 8.1e-13 48.6 0.0 2.5e-12 47.0 0.0 1.8 3 0 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 PIK56628.1 - 7.1e-05 23.1 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK56628.1 - 0.0005 20.1 0.1 0.0019 18.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK56628.1 - 0.0025 17.4 0.1 0.0053 16.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 PIK56628.1 - 0.0095 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ABC_tran PF00005.27 PIK56628.1 - 0.012 16.2 0.5 0.043 14.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 PIK56628.1 - 0.019 15.3 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 PIK56628.1 - 0.029 14.8 0.1 0.069 13.6 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Aminotran_5 PF00266.19 PIK56628.1 - 0.054 12.4 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Bac_DnaA PF00308.18 PIK56628.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein IDO PF01231.18 PIK56629.1 - 0.018 13.9 0.0 0.076 11.8 0.0 1.8 2 0 0 2 2 2 0 Indoleamine 2,3-dioxygenase CsgA PF17334.2 PIK56630.1 - 0.018 15.7 0.8 1.2 9.9 0.0 3.5 3 0 0 3 3 3 0 Minor curli fiber component A V-set PF07686.17 PIK56631.1 - 2.7e-08 34.0 0.0 1.8e-07 31.3 0.0 2.5 2 0 0 2 2 1 1 Immunoglobulin V-set domain NACHT PF05729.12 PIK56631.1 - 3.7e-06 27.0 0.1 8.8e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 NACHT domain ig PF00047.25 PIK56631.1 - 2.7e-05 24.2 0.9 0.00047 20.3 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 PIK56631.1 - 4e-05 24.1 0.6 0.00023 21.7 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain KdpD PF02702.17 PIK56631.1 - 4e-05 23.2 0.1 8e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain I-set PF07679.16 PIK56631.1 - 0.00011 22.2 0.1 0.00079 19.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain KAP_NTPase PF07693.14 PIK56631.1 - 0.0018 17.6 0.0 0.0049 16.1 0.0 1.7 1 0 0 1 1 1 1 KAP family P-loop domain Lyase_8_C PF02884.17 PIK56631.1 - 0.0024 18.3 0.0 4.5 7.8 0.0 2.7 2 0 0 2 2 2 2 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Cadherin_C_2 PF16492.5 PIK56631.1 - 0.0064 17.2 0.0 0.044 14.5 0.0 2.5 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal AAA_19 PF13245.6 PIK56631.1 - 0.021 15.1 0.1 0.25 11.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain Insulin_TMD PF17870.1 PIK56631.1 - 0.039 14.0 0.6 0.039 14.0 0.6 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment NB-ARC PF00931.22 PIK56631.1 - 0.045 12.9 0.8 0.093 11.9 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain UL41A PF17591.2 PIK56631.1 - 0.067 13.3 0.1 0.18 11.9 0.1 1.7 1 0 0 1 1 1 0 Herpesvirus UL41A EphA2_TM PF14575.6 PIK56631.1 - 0.074 13.9 0.1 0.29 12.0 0.1 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OAD_gamma PF04277.13 PIK56631.1 - 0.15 12.7 0.0 0.36 11.5 0.0 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain MAP17 PF15807.5 PIK56631.1 - 0.15 12.3 1.3 0.35 11.1 0.1 2.2 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Syndecan PF01034.20 PIK56631.1 - 0.16 11.9 0.1 0.4 10.6 0.1 1.7 1 0 0 1 1 1 0 Syndecan domain SVA PF05326.11 PIK56631.1 - 2.9 7.9 6.5 3.4 7.7 0.7 3.3 3 1 0 3 3 3 0 Seminal vesicle autoantigen (SVA) Pkinase_Tyr PF07714.17 PIK56632.1 - 3.9e-10 39.4 0.1 6.6e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_A22 PF04848.13 PIK56632.1 - 0.059 13.5 1.3 0.14 12.3 1.3 1.6 1 0 0 1 1 1 0 Poxvirus A22 protein MtrG PF04210.13 PIK56633.1 - 0.0038 17.1 0.2 0.0061 16.4 0.2 1.4 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit G DUF3821 PF12863.7 PIK56634.1 - 0.091 12.6 1.6 0.13 12.2 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3821) PT PF04886.12 PIK56635.1 - 1.4e-19 69.3 164.4 0.00027 20.4 5.7 13.6 11 2 0 11 11 11 11 PT repeat NACHT PF05729.12 PIK56636.1 - 1.7e-08 34.6 0.1 3.1e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK56636.1 - 0.0031 17.9 0.0 0.012 16.0 0.0 2.0 2 1 1 3 3 3 1 AAA ATPase domain Tmem26 PF09772.9 PIK56636.1 - 0.0038 16.6 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Transmembrane protein 26 ABC_tran PF00005.27 PIK56636.1 - 0.0039 17.7 0.1 0.0093 16.5 0.1 1.6 1 0 0 1 1 1 1 ABC transporter AAA PF00004.29 PIK56636.1 - 0.019 15.4 0.0 0.057 13.8 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 PIK56636.1 - 0.027 14.4 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 PIK56636.1 - 0.046 13.7 0.1 0.28 11.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 PIK56636.1 - 0.059 13.8 0.0 0.23 11.9 0.0 2.1 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 PIK56636.1 - 0.072 12.6 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 PIK56636.1 - 0.078 13.2 0.1 0.72 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 PIK56637.1 - 5.6e-08 32.9 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK56637.1 - 0.0013 19.2 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK56637.1 - 0.0033 16.7 2.8 0.015 14.5 0.3 2.3 2 0 0 2 2 2 1 NB-ARC domain C1-set PF07654.15 PIK56637.1 - 0.0062 16.9 0.9 0.026 14.9 0.9 2.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ABC_tran PF00005.27 PIK56637.1 - 0.013 16.0 0.4 0.037 14.5 0.1 2.1 2 1 0 2 2 2 0 ABC transporter Nsp1_C PF05064.13 PIK56637.1 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Nsp1-like C-terminal region AAA PF00004.29 PIK56637.1 - 0.066 13.6 0.0 0.15 12.5 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) V-set PF07686.17 PIK56637.1 - 0.082 13.1 0.8 0.94 9.7 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin V-set domain RuvB_N PF05496.12 PIK56637.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MMR_HSR1 PF01926.23 PIK56637.1 - 0.15 12.2 0.1 1.1 9.4 0.0 2.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase Pkinase_Tyr PF07714.17 PIK56638.1 - 1.1e-24 87.2 0.0 1.3e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56638.1 - 1.2e-16 60.9 0.0 1.4e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TPR_2 PF07719.17 PIK56640.1 - 0.059 13.5 0.0 21 5.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56640.1 - 0.09 13.6 0.0 31 5.7 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK56640.1 - 0.13 12.5 1.5 1.6 9.0 0.2 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-C2H2 PF00096.26 PIK56641.1 - 0.04 14.4 0.4 0.14 12.7 0.4 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK56641.1 - 0.083 13.8 0.4 0.083 13.8 0.4 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 PIK56641.1 - 2.5 8.3 7.3 5.1 7.3 6.0 2.1 1 1 1 2 2 2 0 Zinc ribbon domain RVT_1 PF00078.27 PIK56642.1 - 0.046 13.2 0.1 0.13 11.7 0.1 1.8 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK56643.1 - 0.00062 19.3 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Linker_histone PF00538.19 PIK56644.1 - 4.1e-21 75.1 0.4 4.1e-21 75.1 0.4 2.6 2 1 1 3 3 3 1 linker histone H1 and H5 family SAPS PF04499.15 PIK56644.1 - 0.65 8.7 10.3 0.74 8.5 10.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 PIK56644.1 - 1.2 8.1 17.4 1.3 7.9 17.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAM_decarbox PF01536.16 PIK56645.1 - 3.9e-45 154.4 1.6 4.5e-45 154.2 1.6 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase SAM_decarbox PF01536.16 PIK56646.1 - 3.5e-38 131.5 0.7 1.5e-20 73.6 0.1 2.0 1 1 1 2 2 2 2 Adenosylmethionine decarboxylase Pkinase PF00069.25 PIK56647.1 - 1e-11 44.8 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56647.1 - 0.00021 20.7 0.0 0.00025 20.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56648.1 - 1.6e-28 99.8 0.0 2.2e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56648.1 - 1.3e-05 24.6 0.0 2.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MTBP_C PF14920.6 PIK56648.1 - 0.0014 18.5 3.9 0.002 17.9 3.9 1.2 1 0 0 1 1 1 1 MDM2-binding Neur_chan_memb PF02932.16 PIK56648.1 - 3.5 7.6 4.5 11 6.0 4.3 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Sec63 PF02889.16 PIK56649.1 - 1.7e-125 417.4 5.7 1.5e-74 250.4 0.2 2.7 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 PIK56649.1 - 2.9e-13 50.0 0.1 6.6e-13 48.8 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK56649.1 - 2.4e-08 34.3 0.0 7.6e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK56649.1 - 1.8e-06 28.1 0.0 4.8e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 PIK56649.1 - 0.0035 16.4 0.0 0.0074 15.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 PIK56649.1 - 0.018 14.5 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF150_C PF17384.2 PIK56649.1 - 0.021 14.9 0.1 0.055 13.6 0.1 1.7 1 0 0 1 1 1 0 RimP C-terminal SH3 domain DEAD PF00270.29 PIK56650.1 - 1.3e-28 99.9 3.2 3.5e-28 98.5 1.9 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK56650.1 - 2.8e-13 50.2 0.5 7e-13 48.9 0.5 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_PWI PF18149.1 PIK56650.1 - 4e-05 23.8 0.1 0.00017 21.8 0.0 2.1 2 0 0 2 2 2 1 N-terminal helicase PWI domain AAA_22 PF13401.6 PIK56650.1 - 0.009 16.3 1.4 0.065 13.5 0.1 2.9 3 1 0 3 3 3 1 AAA domain Sec63 PF02889.16 PIK56650.1 - 0.024 13.8 0.2 0.044 12.9 0.2 1.4 1 0 0 1 1 1 0 Sec63 Brl domain AAA_19 PF13245.6 PIK56650.1 - 0.041 14.2 0.6 0.16 12.3 0.6 2.0 1 0 0 1 1 1 0 AAA domain ParA PF10609.9 PIK56650.1 - 0.047 13.1 3.9 0.56 9.6 0.0 2.7 2 1 1 3 3 3 0 NUBPL iron-transfer P-loop NTPase IstB_IS21 PF01695.17 PIK56650.1 - 0.068 12.9 0.4 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_11 PF13086.6 PIK56650.1 - 0.26 11.0 3.3 0.71 9.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 PIK56650.1 - 0.3 10.5 3.3 0.14 11.7 0.3 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_23 PF13476.6 PIK56650.1 - 5.1 7.6 9.6 14 6.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain XTBD PF11952.8 PIK56651.1 - 4e-24 84.2 0.5 6.9e-24 83.4 0.5 1.3 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD Pkinase PF00069.25 PIK56652.1 - 1.3e-65 221.4 0.0 2.1e-65 220.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56652.1 - 3.9e-41 141.1 0.0 7.9e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK56652.1 - 1.1e-07 31.5 0.0 2.7e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK56652.1 - 0.00014 20.8 0.1 0.00032 19.6 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 PIK56652.1 - 0.0069 16.0 0.6 0.029 13.9 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 PIK56652.1 - 0.013 14.9 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ApoLp-III PF07464.11 PIK56652.1 - 0.052 13.6 0.3 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) POTRA_TamA_1 PF17243.2 PIK56652.1 - 0.42 10.7 2.4 0.57 10.3 0.0 2.4 3 0 0 3 3 3 0 POTRA domain TamA domain 1 Toxin_2 PF00451.19 PIK56652.1 - 1 9.7 3.8 4.9 7.5 1.1 2.7 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 tRNA-synt_1b PF00579.25 PIK56653.1 - 9.9e-47 159.7 0.0 2.5e-46 158.4 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Prenyltransf PF01255.19 PIK56654.1 - 2.7e-06 27.1 0.0 4.4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RcpC PF16976.5 PIK56655.1 - 0.044 13.8 0.2 0.093 12.8 0.2 1.6 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB Yippee-Mis18 PF03226.14 PIK56656.1 - 8.4e-15 54.9 1.3 1.4e-14 54.2 0.4 1.8 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2854 PF11016.8 PIK56656.1 - 0.009 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2854) 5_nucleotid PF05761.14 PIK56657.1 - 6.2e-44 150.7 0.0 1e-43 149.9 0.0 1.2 1 0 0 1 1 1 1 5' nucleotidase family Tox-PL-2 PF15643.6 PIK56657.1 - 0.0076 16.4 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Papain fold toxin 2 SNF2_N PF00176.23 PIK56658.1 - 1.2e-21 76.9 0.0 2e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HHH_3 PF12836.7 PIK56658.1 - 0.002 18.3 0.1 0.0051 17.0 0.0 1.6 2 0 0 2 2 2 1 Helix-hairpin-helix motif Helicase_C PF00271.31 PIK56659.1 - 3.4e-17 62.8 0.0 6.2e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 PIK56659.1 - 9.1e-06 25.1 0.0 2.1e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SNF2_N PF00176.23 PIK56659.1 - 0.036 12.8 0.1 0.036 12.8 0.1 1.6 2 0 0 2 2 2 0 SNF2 family N-terminal domain RVT_2 PF07727.14 PIK56660.1 - 1.4e-78 263.9 2.1 2.1e-78 263.3 2.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK56660.1 - 2.3e-06 27.8 0.0 6.4e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DUF432 PF04254.13 PIK56660.1 - 0.037 14.2 0.2 0.08 13.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF432) Retrotran_gag_2 PF14223.6 PIK56661.1 - 1.7e-20 73.1 0.1 3.1e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 PIK56661.1 - 1.4e-05 24.9 0.6 4.9e-05 23.2 0.6 2.0 1 0 0 1 1 1 1 Zinc knuckle TerY_C PF15616.6 PIK56661.1 - 0.0097 16.0 0.3 0.03 14.4 0.1 1.8 2 0 0 2 2 2 1 TerY-C metal binding domain Glyoxalase_2 PF12681.7 PIK56661.1 - 0.036 14.0 0.3 2.3 8.2 0.1 2.8 1 1 2 3 3 3 0 Glyoxalase-like domain DIX PF00778.17 PIK56661.1 - 0.13 12.1 0.9 0.53 10.2 0.1 2.2 2 0 0 2 2 2 0 DIX domain zf-CCHC_4 PF14392.6 PIK56661.1 - 7.7 6.3 6.4 19 5.1 0.6 3.2 3 0 0 3 3 3 0 Zinc knuckle DUF1704 PF08014.11 PIK56662.1 - 0.00072 18.7 0.0 0.23 10.4 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1704) DUF3421 PF11901.8 PIK56663.1 - 1.3e-05 25.2 0.1 3.1e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3421) ETX_MTX2 PF03318.13 PIK56663.1 - 2e-05 24.5 12.6 2.9e-05 23.9 12.6 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 PIK56663.1 - 0.00042 19.6 4.7 0.00055 19.3 4.7 1.2 1 0 0 1 1 1 1 Aerolysin toxin MspA PF09203.11 PIK56663.1 - 0.023 14.6 0.5 0.03 14.2 0.5 1.1 1 0 0 1 1 1 0 MspA 4_1_CTD PF05902.13 PIK56663.1 - 0.032 14.3 2.0 0.032 14.3 2.0 2.0 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) MFS_1 PF07690.16 PIK56664.1 - 0.0047 15.9 2.1 0.0058 15.6 2.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ATP1G1_PLM_MAT8 PF02038.16 PIK56664.1 - 0.18 11.3 9.7 0.85 9.1 1.4 3.1 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family DUF2897 PF11446.8 PIK56664.1 - 0.19 11.7 0.5 0.33 10.9 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) CD20 PF04103.15 PIK56664.1 - 0.4 10.7 7.6 0.74 9.9 7.4 1.6 1 1 0 1 1 1 0 CD20-like family ZU5 PF00791.20 PIK56665.1 - 5e-22 78.1 0.0 3e-11 43.5 0.0 2.6 2 0 0 2 2 2 2 ZU5 domain ERM PF00769.19 PIK56666.1 - 6e-06 26.3 59.6 0.014 15.3 25.5 2.2 1 1 1 2 2 2 2 Ezrin/radixin/moesin family GAS PF13851.6 PIK56666.1 - 1.4e-05 24.6 50.1 0.013 14.8 23.6 2.5 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 PIK56666.1 - 7.7e-05 22.4 50.3 0.064 12.9 16.3 3.3 1 1 2 3 3 3 3 Ciliary protein causing Leber congenital amaurosis disease APG6_N PF17675.1 PIK56666.1 - 0.0002 21.9 63.0 1.1 9.8 25.7 3.3 1 1 1 2 2 2 1 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 PIK56666.1 - 0.0048 17.5 54.6 0.044 14.4 21.8 3.3 1 1 1 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 KASH_CCD PF14662.6 PIK56666.1 - 0.05 13.4 53.1 0.2 11.4 20.8 3.6 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF4472 PF14739.6 PIK56666.1 - 0.085 13.6 44.0 0.86 10.4 18.6 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4472) PI3K_P85_iSH2 PF16454.5 PIK56666.1 - 0.26 10.9 40.9 0.25 10.9 12.7 3.9 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain T3SSipB PF16535.5 PIK56666.1 - 0.29 11.6 30.9 14 6.1 17.5 3.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB ATG16 PF08614.11 PIK56666.1 - 0.7 10.1 56.2 2 8.6 33.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 PIK56666.1 - 0.75 9.0 42.6 6.1 6.1 22.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Mei5 PF10376.9 PIK56666.1 - 0.84 9.5 36.9 1.1 9.1 10.2 3.3 1 1 2 3 3 3 0 Double-strand recombination repair protein TACC_C PF05010.14 PIK56666.1 - 0.91 9.3 43.0 1.1 9.0 23.0 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Suppressor_APC PF11414.8 PIK56666.1 - 1.1 9.4 33.9 0.83 9.8 2.1 4.2 1 1 3 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein DUF4600 PF15372.6 PIK56666.1 - 1.1 9.7 37.6 33 4.9 8.2 4.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) Sec20 PF03908.13 PIK56666.1 - 1.2 9.1 27.9 2.8 7.9 3.3 4.7 2 1 3 5 5 5 0 Sec20 CALCOCO1 PF07888.11 PIK56666.1 - 1.4 7.7 53.6 3.9 6.2 53.6 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 PIK56666.1 - 1.6 8.7 51.7 2.1 8.4 14.9 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 PIK56666.1 - 1.7 7.5 48.9 2.1 7.1 27.6 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein FlgN PF05130.12 PIK56666.1 - 1.8 9.1 44.3 50 4.4 13.6 4.1 1 1 1 2 2 2 0 FlgN protein DUF1664 PF07889.12 PIK56666.1 - 1.8 8.6 25.3 1.1 9.3 7.8 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) COG2 PF06148.11 PIK56666.1 - 1.9 8.6 26.4 0.46 10.6 7.9 3.5 2 1 2 4 4 3 0 COG (conserved oligomeric Golgi) complex component, COG2 FPP PF05911.11 PIK56666.1 - 2.8 6.0 45.4 1.9 6.5 26.2 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Tropomyosin_1 PF12718.7 PIK56666.1 - 3.2 7.9 55.1 4.3 7.5 27.2 2.4 1 1 1 2 2 2 0 Tropomyosin like DUF4284 PF14112.6 PIK56666.1 - 3.6 8.5 6.9 6.7 7.7 0.0 3.4 1 1 0 3 3 3 0 Immunity protein 22 Laminin_II PF06009.12 PIK56666.1 - 4.1 7.4 25.3 10 6.1 10.2 2.8 1 1 1 2 2 2 0 Laminin Domain II SOGA PF11365.8 PIK56666.1 - 5.1 8.3 39.7 14 6.8 6.4 3.6 1 1 3 4 4 4 0 Protein SOGA Nmad4 PF18756.1 PIK56666.1 - 5.4 7.4 12.3 22 5.5 0.2 4.2 2 1 2 4 4 4 0 Nucleotide modification associated domain 4 T2SSN PF01203.19 PIK56666.1 - 6.2 7.0 14.5 51 4.0 3.6 3.4 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein N Rho_Binding PF08912.11 PIK56666.1 - 7.3 7.5 50.7 2.5 9.0 8.5 4.6 1 1 3 4 4 4 0 Rho Binding DUF4200 PF13863.6 PIK56666.1 - 8.5 6.8 53.0 5.6 7.4 25.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4172 PF13776.6 PIK56666.1 - 9 6.7 14.5 29 5.1 0.7 4.2 1 1 4 5 5 5 0 Domain of unknown function (DUF4172) Nsp1_C PF05064.13 PIK56666.1 - 9 6.1 38.1 3 7.7 10.9 3.8 1 1 3 4 4 4 0 Nsp1-like C-terminal region gag-asp_proteas PF13975.6 PIK56667.1 - 0.0012 19.4 0.1 0.003 18.1 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK56667.1 - 0.0082 16.8 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Phage_sheath_1C PF17482.2 PIK56667.1 - 0.019 15.0 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain RVP PF00077.20 PIK56667.1 - 0.026 14.8 0.1 0.1 12.9 0.0 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease V-ATPase_H_C PF11698.8 PIK56668.1 - 1.7e-48 163.6 0.4 5.3e-48 162.0 0.0 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 PIK56668.1 - 8.6e-10 38.4 2.5 1.4e-09 37.7 1.5 1.7 2 0 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.13 PIK56668.1 - 0.00077 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Armadillo-like Arm PF00514.23 PIK56668.1 - 0.0013 18.6 0.2 3.7 7.7 0.1 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 PIK56668.1 - 0.0058 17.0 0.0 0.018 15.4 0.0 1.8 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 PIK56668.1 - 0.013 15.7 0.0 0.4 11.1 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat L51_S25_CI-B8 PF05047.16 PIK56668.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Phage_int_SAM_4 PF13495.6 PIK56669.1 - 0.00084 19.8 0.1 0.0016 18.9 0.1 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK56669.1 - 0.0024 18.1 0.2 0.0052 17.1 0.2 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Herpes_BLLF1 PF05109.13 PIK56669.1 - 0.016 13.3 6.0 0.025 12.6 6.0 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Phage_integrase PF00589.22 PIK56670.1 - 0.0084 15.9 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Hist_deacetyl PF00850.19 PIK56671.1 - 4.6e-84 282.5 0.2 8.6e-84 281.6 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain RRM_1 PF00076.22 PIK56672.1 - 7.1e-39 131.5 1.1 1.2e-11 44.2 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK56672.1 - 7.3e-06 25.8 0.0 1.7 8.5 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 PIK56672.1 - 7.6e-05 22.6 4.3 0.0021 18.0 0.1 3.5 3 1 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 PIK56672.1 - 0.0069 16.4 0.0 0.032 14.3 0.0 2.1 2 0 0 2 2 2 1 RNA binding domain O-FucT PF10250.9 PIK56672.1 - 0.038 13.7 0.1 0.086 12.5 0.1 1.5 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase RRM_5 PF13893.6 PIK56672.1 - 0.08 12.5 0.2 5.7 6.6 0.0 2.9 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 PIK56673.1 - 2.4e-12 46.8 0.0 1.3e-11 44.4 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 PIK56673.1 - 0.0054 16.9 0.0 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase BRCT PF00533.26 PIK56674.1 - 1.9e-07 31.3 0.1 5.2e-07 30.0 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK56674.1 - 0.00035 20.9 0.0 0.0011 19.3 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 PIK56674.1 - 0.0017 18.2 0.1 0.0045 16.9 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 PIK56674.1 - 0.0031 17.4 0.0 0.011 15.6 0.0 2.0 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain zf-C3HC4 PF00097.25 PIK56676.1 - 2.3e-09 37.0 9.1 4.8e-09 35.9 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK56676.1 - 5.3e-08 32.6 9.9 1e-07 31.7 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK56676.1 - 8.8e-08 32.2 9.7 1.8e-07 31.2 9.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK56676.1 - 2.8e-07 30.3 6.7 5.1e-07 29.5 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK56676.1 - 6.9e-07 29.5 8.1 1.4e-06 28.5 8.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK56676.1 - 5.2e-06 26.4 9.3 1.4e-05 25.0 9.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK56676.1 - 2.6e-05 24.1 7.9 5.2e-05 23.1 7.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 PIK56676.1 - 2.9e-05 23.8 1.7 6.4e-05 22.8 1.7 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 PIK56676.1 - 0.00039 20.5 4.5 0.00098 19.2 4.5 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.8 PIK56676.1 - 0.0027 17.5 5.1 0.0054 16.5 5.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 PIK56676.1 - 0.012 15.4 7.5 0.024 14.5 7.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 PIK56676.1 - 0.076 12.8 4.9 0.18 11.6 4.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 PIK56676.1 - 0.14 12.2 1.5 0.28 11.2 1.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 PIK56676.1 - 0.15 12.3 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 U-box domain Mso1_Sec1_bdg PF14475.6 PIK56676.1 - 0.22 11.2 1.3 0.75 9.4 1.3 2.0 1 0 0 1 1 1 0 Sec1-binding region of Mso1 zf-rbx1 PF12678.7 PIK56676.1 - 0.25 11.7 6.1 0.62 10.4 6.1 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-MIZ PF02891.20 PIK56676.1 - 6.3 6.6 6.6 11 5.9 6.6 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger DUF4203 PF13886.6 PIK56677.1 - 3e-35 121.7 24.8 3.7e-35 121.4 24.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) BRI3BP PF14965.6 PIK56677.1 - 0.44 10.1 8.1 0.62 9.6 7.2 1.7 1 1 0 1 1 1 0 Negative regulator of p53/TP53 Phage_holin_5_2 PF16079.5 PIK56677.1 - 0.46 10.8 13.8 0.43 10.9 1.0 2.9 1 1 2 3 3 3 0 Phage holin family Hol44, in holin superfamily V CDC45 PF02724.14 PIK56679.1 - 0.1 10.9 2.8 0.12 10.7 2.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2020 PF09449.10 PIK56679.1 - 0.39 10.6 2.0 2.8 7.7 1.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2020) Oxysterol_BP PF01237.18 PIK56679.1 - 1.3 7.8 4.2 1.5 7.6 4.2 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein FAM176 PF14851.6 PIK56679.1 - 2 8.1 7.7 3.7 7.2 7.7 1.4 1 0 0 1 1 1 0 FAM176 family GRP PF07172.11 PIK56679.1 - 3.5 8.4 5.6 0.63 10.8 0.7 1.9 2 0 0 2 2 2 0 Glycine rich protein family DUF3682 PF12446.8 PIK56679.1 - 3.6 8.1 7.8 2 8.9 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Arf PF00025.21 PIK56681.1 - 1.9e-72 242.3 0.1 2.3e-72 242.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK56681.1 - 2.3e-14 53.7 0.0 3.3e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK56681.1 - 1.5e-13 50.6 0.0 1.9e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK56681.1 - 1.3e-12 47.6 1.3 1.3e-08 34.4 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 PIK56681.1 - 1.5e-12 47.4 0.0 1.7e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 PIK56681.1 - 1.5e-11 44.1 0.0 1.8e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK56681.1 - 2.7e-06 27.4 0.0 4.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK56681.1 - 0.0032 16.8 0.8 0.011 15.0 0.8 1.9 1 1 0 1 1 1 1 6-phosphofructo-2-kinase NACHT PF05729.12 PIK56681.1 - 0.031 14.2 0.3 0.077 12.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 PIK56681.1 - 0.085 12.4 0.2 0.62 9.6 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 PIK56682.1 - 1e-77 259.5 0.1 1.1e-77 259.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK56682.1 - 9.1e-14 51.7 0.0 1.3e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 PIK56682.1 - 1.5e-13 50.6 0.0 1.8e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK56682.1 - 1.1e-12 47.8 0.7 1.2e-08 34.5 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 PIK56682.1 - 1.7e-12 47.2 0.0 1.9e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 PIK56682.1 - 7e-11 41.9 0.0 8.5e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 PIK56682.1 - 8.3e-06 25.9 0.0 1.2e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 PIK56682.1 - 0.0081 15.5 0.3 0.015 14.7 0.3 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 PIK56682.1 - 0.07 13.3 0.3 0.34 11.1 0.3 2.0 1 1 0 1 1 1 0 AAA domain Csm1_B PF18211.1 PIK56682.1 - 0.081 12.8 0.0 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Csm1 subunit domain B cobW PF02492.19 PIK56682.1 - 0.21 11.1 0.2 1.5 8.3 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMtag PF10159.9 PIK56683.1 - 4.2e-07 30.2 0.1 4.2e-07 30.2 0.1 3.3 3 1 0 3 3 3 1 Multiple myeloma tumor-associated Tex_YqgF PF16921.5 PIK56684.1 - 3.2e-43 147.2 0.0 6.3e-43 146.2 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain Tex_N PF09371.10 PIK56684.1 - 1.1e-26 93.7 7.6 1.6e-24 86.6 2.3 2.3 1 1 1 2 2 2 2 Tex-like protein N-terminal domain HHH_3 PF12836.7 PIK56684.1 - 8.8e-26 90.0 0.1 5.7e-25 87.4 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_9 PF17674.1 PIK56684.1 - 1.7e-11 44.9 0.1 2e-10 41.4 0.0 2.8 2 0 0 2 2 2 1 HHH domain HHH_7 PF14635.6 PIK56684.1 - 6.5e-11 42.5 0.0 1.8e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 PIK56684.1 - 1.2e-05 25.2 0.0 3.8e-05 23.5 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_5 PF14520.6 PIK56684.1 - 0.0011 19.6 2.2 0.56 10.9 0.3 3.9 2 1 1 3 3 3 1 Helix-hairpin-helix domain HHH PF00633.23 PIK56684.1 - 0.0014 18.4 0.0 3.4 7.7 0.0 3.1 3 0 0 3 3 3 2 Helix-hairpin-helix motif DUF4487 PF14868.6 PIK56684.1 - 0.23 10.2 0.7 0.36 9.6 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) Glycos_transf_2 PF00535.26 PIK56685.1 - 1.9e-33 115.7 0.0 3.1e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 PIK56685.1 - 3.5e-18 66.1 0.5 5.8e-18 65.4 0.5 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 PIK56685.1 - 1.2e-09 38.0 0.0 1.2e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 PIK56685.1 - 1.1e-08 34.6 0.0 2.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 PIK56685.1 - 7.1e-07 29.3 0.0 3.1e-06 27.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 PIK56685.1 - 0.00015 22.4 0.0 0.85 10.4 0.0 2.5 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like LRR_8 PF13855.6 PIK56686.1 - 6.3e-46 154.0 36.3 1.8e-15 56.4 6.1 5.3 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK56686.1 - 2.3e-22 79.3 11.2 1.2e-12 47.9 0.8 3.2 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56686.1 - 3.6e-21 74.9 42.6 2.2e-06 27.9 1.4 6.5 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56686.1 - 2.5e-17 63.0 14.8 1.2e-08 34.7 1.6 4.3 1 1 3 4 4 4 4 Leucine-rich repeat Ig_3 PF13927.6 PIK56686.1 - 1.4e-07 32.0 0.0 3.6e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK56686.1 - 1e-05 25.5 0.0 2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_1 PF00560.33 PIK56686.1 - 0.0002 21.4 30.2 2.2 9.2 0.0 9.4 9 1 0 9 9 8 2 Leucine Rich Repeat ig PF00047.25 PIK56686.1 - 0.00035 20.7 0.0 0.00075 19.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK56686.1 - 0.0014 19.0 0.0 0.0034 17.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.18 PIK56686.1 - 0.0033 17.0 3.4 0.0033 17.0 3.4 2.4 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain HTH_25 PF13413.6 PIK56686.1 - 0.045 13.6 0.0 12 5.9 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain Beta_helix PF13229.6 PIK56686.1 - 0.063 13.1 4.1 0.1 12.5 1.1 2.3 1 1 1 2 2 2 0 Right handed beta helix region ABC_membrane PF00664.23 PIK56687.1 - 2.5e-110 368.4 29.2 2.2e-63 214.5 7.4 2.8 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 PIK56687.1 - 6.2e-72 240.5 2.3 3.4e-36 124.8 0.0 3.0 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 PIK56687.1 - 1.2e-16 60.9 0.8 4e-07 29.7 0.0 2.9 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 PIK56687.1 - 7.1e-07 28.4 0.5 0.0064 15.3 0.0 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 PIK56687.1 - 5.3e-06 26.9 6.4 0.015 15.7 0.1 3.4 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 PIK56687.1 - 6.8e-06 26.4 0.8 0.12 12.7 0.0 3.5 2 2 0 2 2 2 2 AAA domain AAA PF00004.29 PIK56687.1 - 2.9e-05 24.5 3.2 0.98 9.8 0.1 4.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 PIK56687.1 - 0.0001 22.6 3.2 2 8.6 0.1 4.0 2 2 1 4 4 4 2 AAA domain AAA_29 PF13555.6 PIK56687.1 - 0.00012 21.8 1.1 0.58 9.9 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 PIK56687.1 - 0.00013 21.4 0.1 0.02 14.2 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin CDC45 PF02724.14 PIK56687.1 - 0.0002 19.8 6.9 0.00035 19.0 6.9 1.3 1 0 0 1 1 1 1 CDC45-like protein RsgA_GTPase PF03193.16 PIK56687.1 - 0.00022 21.2 0.3 0.46 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 PIK56687.1 - 0.00029 21.0 6.3 0.34 11.2 0.4 4.3 3 2 0 3 3 2 2 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 PIK56687.1 - 0.00046 19.9 0.1 1.1 8.8 0.0 2.6 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain G-alpha PF00503.20 PIK56687.1 - 0.002 17.3 0.0 0.27 10.4 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit Rad17 PF03215.15 PIK56687.1 - 0.0023 17.9 0.2 2.2 8.2 0.0 2.7 3 0 0 3 3 2 1 Rad17 P-loop domain AAA_30 PF13604.6 PIK56687.1 - 0.0031 17.2 2.2 0.5 10.0 0.1 3.3 2 2 0 2 2 2 1 AAA domain DUF87 PF01935.17 PIK56687.1 - 0.0037 17.4 6.3 0.32 11.1 0.0 3.7 4 0 0 4 4 4 2 Helicase HerA, central domain DUF815 PF05673.13 PIK56687.1 - 0.0051 16.0 0.1 1 8.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 PIK56687.1 - 0.0085 16.1 0.2 10 6.1 0.0 3.6 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK56687.1 - 0.031 13.8 0.1 3.9 6.9 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 PIK56687.1 - 0.031 14.0 0.2 4.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF2207 PF09972.9 PIK56687.1 - 0.034 12.9 0.0 0.034 12.9 0.0 4.4 4 2 1 5 5 4 0 Predicted membrane protein (DUF2207) RNA_helicase PF00910.22 PIK56687.1 - 0.055 13.9 0.1 15 6.0 0.0 3.1 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 PIK56687.1 - 0.058 13.1 0.0 5.2 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain YebG PF07130.12 PIK56687.1 - 0.093 12.6 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 YebG protein AAA_33 PF13671.6 PIK56687.1 - 0.14 12.3 0.1 23 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK56687.1 - 0.16 11.5 1.6 14 5.2 0.2 2.9 3 1 0 3 3 3 0 AAA domain TLP-20 PF06088.11 PIK56687.1 - 0.25 11.2 2.6 2.1 8.2 2.5 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PI3K_1B_p101 PF10486.9 PIK56687.1 - 1.2 6.8 7.3 0.58 7.9 5.2 1.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DDRGK PF09756.9 PIK56687.1 - 2 8.0 13.5 4.4 6.8 13.5 1.5 1 0 0 1 1 1 0 DDRGK domain Pox_RNA_Pol_19 PF05320.12 PIK56687.1 - 2 8.3 7.9 6.3 6.7 7.9 1.8 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit LRR_9 PF14580.6 PIK56688.1 - 4.1e-11 42.7 2.8 5.7e-11 42.2 1.3 1.9 2 1 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 PIK56688.1 - 2.2e-08 33.7 4.5 0.00019 21.2 0.3 2.9 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK56688.1 - 1.7e-07 31.5 11.6 0.00012 22.4 3.0 4.3 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK56688.1 - 0.42 11.4 4.5 28 5.8 0.1 4.3 4 1 0 4 4 4 0 Leucine Rich Repeat His_leader PF08047.11 PIK56689.1 - 9.5 6.4 22.7 0.4 10.7 11.9 2.5 2 0 0 2 2 2 0 Histidine operon leader peptide Man-6-P_recep PF02157.15 PIK56691.1 - 2.1e-16 59.8 0.1 2.9e-16 59.3 0.1 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 PIK56691.1 - 5.8e-13 49.3 0.1 7.5e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 TLC PF03219.14 PIK56691.1 - 0.0051 15.6 0.1 0.0072 15.1 0.1 1.1 1 0 0 1 1 1 1 TLC ATP/ADP transporter zf-C2H2_jaz PF12171.8 PIK56692.1 - 2.6e-12 46.7 59.3 0.00015 21.9 2.5 8.9 8 0 0 8 8 8 7 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK56692.1 - 2.2e-07 31.1 88.4 0.0077 17.0 1.8 10.5 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK56692.1 - 3.1e-05 24.2 65.2 0.00088 19.6 0.5 9.2 9 0 0 9 9 9 5 Zinc-finger double domain zf-C2H2 PF00096.26 PIK56692.1 - 4.2e-05 23.8 87.5 0.005 17.2 1.8 9.7 10 0 0 10 10 10 6 Zinc finger, C2H2 type zf-met PF12874.7 PIK56692.1 - 0.02 15.2 2.7 0.02 15.2 2.7 8.0 10 0 0 10 10 10 0 Zinc-finger of C2H2 type Acyl_CoA_thio PF02551.15 PIK56692.1 - 0.14 12.0 1.6 0.31 10.9 1.6 1.5 1 0 0 1 1 1 0 Acyl-CoA thioesterase Ta0938 PF11494.8 PIK56692.1 - 6.8 7.0 7.1 4.6 7.6 1.2 3.4 2 1 0 3 3 3 0 Ta0938 zf-H2C2_2 PF13465.6 PIK56693.1 - 2.2e-45 151.1 124.6 3.8e-07 30.2 3.5 14.9 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56693.1 - 7.2e-23 79.3 123.2 0.0029 18.3 0.7 14.2 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56693.1 - 1.9e-22 78.4 129.9 8.8e-05 22.7 7.2 14.3 14 0 0 14 14 14 10 Zinc finger, C2H2 type PyrI_C PF02748.15 PIK56693.1 - 1.4e-07 31.3 69.0 0.34 10.9 0.6 13.5 12 2 1 13 13 13 7 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK56693.1 - 4.1e-06 26.9 85.6 0.023 15.0 0.6 13.3 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK56693.1 - 0.085 13.0 82.8 4.6 7.5 0.2 13.9 12 2 2 14 14 14 0 AN1-like Zinc finger DUF3268 PF11672.8 PIK56693.1 - 0.095 13.0 48.1 0.79 10.1 1.8 7.0 5 2 1 7 7 7 0 zinc-finger-containing domain PRNT PF15174.6 PIK56693.1 - 0.25 11.4 4.8 33 4.6 0.0 4.2 3 1 1 4 4 4 0 Prion-related protein testis-specific zf-met PF12874.7 PIK56693.1 - 7.2 7.1 68.3 2 9.0 1.3 11.7 12 0 0 12 12 12 0 Zinc-finger of C2H2 type dNK PF01712.19 PIK56694.1 - 1.2e-32 113.5 0.0 1.8e-32 112.9 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 PIK56694.1 - 0.00025 21.6 0.1 0.00098 19.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 PIK56694.1 - 0.00025 20.8 0.1 0.00075 19.2 0.0 1.7 2 0 0 2 2 2 1 Thymidylate kinase AAA_28 PF13521.6 PIK56694.1 - 0.0003 21.1 0.0 0.00055 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 PIK56694.1 - 0.0047 16.9 0.0 0.014 15.4 0.0 1.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 PIK56694.1 - 0.015 15.4 0.0 0.16 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 PIK56694.1 - 0.032 14.0 0.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase SKI PF01202.22 PIK56694.1 - 0.094 12.8 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase PXA PF02194.15 PIK56695.1 - 3.4e-49 167.3 1.4 1e-48 165.7 1.4 1.9 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 PIK56695.1 - 2e-26 92.8 5.6 2.5e-26 92.5 0.5 3.1 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 PIK56695.1 - 5.7e-20 71.4 0.5 1.5e-19 70.1 0.0 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.19 PIK56695.1 - 3.6e-17 62.7 0.2 3.6e-17 62.7 0.2 2.8 3 0 0 3 3 3 1 Regulator of G protein signaling domain NAD_binding_1 PF00175.21 PIK56696.1 - 1.8e-11 44.7 0.0 3e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 PIK56696.1 - 1.3e-05 25.3 0.5 0.02 15.0 0.4 2.7 1 1 1 2 2 2 2 Ferric reductase NAD binding domain 7tm_1 PF00001.21 PIK56697.1 - 1.4e-32 113.1 13.0 1.8e-32 112.7 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK56697.1 - 3.9e-09 36.5 11.9 3.9e-09 36.5 11.9 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK56697.1 - 9.1e-08 31.8 12.8 1.4e-07 31.2 12.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 PIK56697.1 - 1.2e-05 24.8 13.0 1.8e-05 24.3 13.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Thioredoxin PF00085.20 PIK56698.1 - 3e-25 88.2 0.3 3.8e-24 84.6 0.0 2.2 2 1 1 3 3 3 1 Thioredoxin Thioredoxin_8 PF13905.6 PIK56698.1 - 3.8e-05 23.9 0.1 0.011 16.1 0.0 3.3 2 1 2 4 4 4 1 Thioredoxin-like Thioredoxin_2 PF13098.6 PIK56698.1 - 0.00033 21.1 0.1 0.0066 16.9 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 PIK56698.1 - 0.0024 18.0 0.0 0.0054 16.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 PIK56698.1 - 0.0086 16.0 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family PRT_C PF08372.10 PIK56698.1 - 0.12 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Thioredoxin_6 PF13848.6 PIK56699.1 - 8.8e-13 48.6 0.1 1.4e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Calsequestrin PF01216.17 PIK56699.1 - 3.3e-05 23.1 0.6 0.0064 15.6 0.2 2.1 1 1 0 2 2 2 2 Calsequestrin Ras PF00071.22 PIK56700.1 - 2.6e-35 121.4 0.0 3.2e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK56700.1 - 1.1e-10 41.8 0.0 1.8e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 PIK56700.1 - 1.2e-06 28.2 0.0 1.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 PIK56700.1 - 3.2e-05 23.5 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 PIK56700.1 - 0.00073 19.4 0.0 0.0009 19.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Molybdopterin PF00384.22 PIK56701.1 - 1e-70 238.9 0.0 4.7e-70 236.7 0.0 1.8 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 PIK56701.1 - 9e-18 64.7 0.4 2.1e-17 63.5 0.4 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2_4 PF13510.6 PIK56701.1 - 4.3e-17 61.9 0.1 1.1e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 PIK56701.1 - 1.8e-16 59.4 0.1 4.8e-16 58.0 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 PIK56701.1 - 3.5e-09 36.5 0.6 3.5e-09 36.5 0.6 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 PIK56701.1 - 0.00028 20.6 0.1 0.78 9.5 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain EF1_GNE PF00736.19 PIK56702.1 - 3.6e-31 107.2 0.3 3.6e-31 107.2 0.3 1.8 3 0 0 3 3 3 1 EF-1 guanine nucleotide exchange domain GST_C_3 PF14497.6 PIK56702.1 - 0.00029 21.0 0.0 0.00074 19.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 PIK56702.1 - 0.043 13.6 0.1 0.096 12.5 0.1 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56702.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CoA_transf_3 PF02515.17 PIK56703.1 - 5.3e-17 62.0 0.2 5.5e-17 61.9 0.2 1.0 1 0 0 1 1 1 1 CoA-transferase family III KH_1 PF00013.29 PIK56704.1 - 6.8e-12 45.0 0.3 9e-12 44.6 0.3 1.2 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 PIK56705.1 - 5.5e-09 35.7 0.1 8.6e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 PIK56705.1 - 0.00064 19.5 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 PIK56706.1 - 3.9e-12 45.8 0.0 5.4e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 PIK56706.1 - 0.00012 21.8 0.1 0.00018 21.2 0.1 1.2 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 PIK56706.1 - 0.0043 16.9 0.3 0.0066 16.3 0.3 1.2 1 0 0 1 1 1 1 KH domain Det1 PF09737.9 PIK56707.1 - 1.5e-188 627.0 4.3 1.9e-188 626.7 4.3 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 PilJ_C PF18223.1 PIK56707.1 - 0.14 12.6 0.0 0.44 11.1 0.0 1.8 1 0 0 1 1 1 0 Pili PilJ C-terminal domain 7tm_1 PF00001.21 PIK56708.1 - 2.2e-22 79.7 5.1 2.8e-22 79.3 5.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 PIK56709.1 - 7.2e-14 51.7 4.7 1e-13 51.2 4.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ig_3 PF13927.6 PIK56710.1 - 4.9e-35 120.0 1.1 4.5e-13 49.6 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK56710.1 - 3e-32 110.5 2.1 2.8e-10 40.1 0.4 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK56710.1 - 8.4e-31 106.2 3.3 2.2e-12 47.1 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK56710.1 - 7.1e-20 71.0 2.6 1.2e-06 28.6 0.2 3.9 3 1 0 3 3 3 3 Immunoglobulin domain Peptidase_C14 PF00656.22 PIK56710.1 - 7.1e-16 58.9 0.1 1.5e-15 57.9 0.1 1.5 1 1 0 1 1 1 1 Caspase domain V-set PF07686.17 PIK56710.1 - 3.1e-14 53.0 5.9 0.029 14.5 0.0 5.8 3 3 3 6 6 6 4 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK56710.1 - 1.1e-08 34.5 0.0 0.02 14.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 PIK56710.1 - 5.5e-07 29.6 0.2 0.76 9.9 0.0 3.5 3 0 0 3 3 3 3 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK56710.1 - 7.3e-05 23.1 5.7 0.016 15.6 0.5 3.4 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK56710.1 - 0.00036 20.8 6.1 0.16 12.2 0.2 3.6 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Death PF00531.22 PIK56710.1 - 0.0032 17.6 0.1 0.008 16.3 0.1 1.7 1 0 0 1 1 1 1 Death domain C2-set_2 PF08205.12 PIK56710.1 - 0.0043 17.1 0.3 0.49 10.5 0.0 3.5 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 PIK56710.1 - 0.019 15.2 0.8 14 5.9 0.0 3.8 4 1 1 5 5 5 0 Natural killer cell receptor 2B4 Phage-MuB_C PF09077.11 PIK56710.1 - 0.075 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Mu B transposition protein, C terminal Lzipper-MIP1 PF14389.6 PIK56710.1 - 0.16 12.3 0.1 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Ig_Tie2_1 PF10430.9 PIK56710.1 - 0.86 10.1 3.0 15 6.1 0.6 3.2 3 0 0 3 3 3 0 Tie-2 Ig-like domain 1 Ion_trans PF00520.31 PIK56711.1 - 1.5e-36 125.9 23.9 2.1e-36 125.4 23.9 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK56711.1 - 0.00085 18.1 21.3 0.0037 16.0 12.1 2.6 2 1 1 3 3 3 2 Polycystin cation channel SpoVAB PF13782.6 PIK56711.1 - 0.37 11.1 5.9 0.2 12.0 0.9 2.2 2 0 0 2 2 2 0 Stage V sporulation protein AB AAA PF00004.29 PIK56712.1 - 1.3e-29 103.3 0.0 4.4e-29 101.6 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK56712.1 - 5.8e-10 38.8 0.0 2.2e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain LisH PF08513.11 PIK56712.1 - 3.2e-06 26.9 0.8 9.2e-06 25.4 0.2 2.2 2 0 0 2 2 2 1 LisH RuvB_N PF05496.12 PIK56712.1 - 0.00017 21.3 0.0 0.00041 20.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK56712.1 - 0.00075 19.9 0.0 0.0017 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 PIK56712.1 - 0.00081 18.7 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 PIK56712.1 - 0.0039 17.2 0.0 0.0081 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK56712.1 - 0.0053 17.0 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK56712.1 - 0.006 17.0 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 PIK56712.1 - 0.0079 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 PIK56712.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK56712.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 PIK56712.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 PIK56712.1 - 0.022 15.3 0.1 0.09 13.3 0.0 2.2 2 1 0 2 2 1 0 AAA domain AAA_33 PF13671.6 PIK56712.1 - 0.038 14.1 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 PIK56712.1 - 0.11 11.6 0.1 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 PIK56712.1 - 0.12 11.8 0.1 0.3 10.5 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 PIK56712.1 - 0.13 11.9 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 PIK56712.1 - 0.17 12.3 0.0 0.74 10.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain Ndc1_Nup PF09531.10 PIK56712.1 - 0.45 9.1 2.1 0.58 8.8 2.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-MIZ PF02891.20 PIK56713.1 - 6.5e-22 77.0 5.3 1.1e-21 76.3 5.3 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 PIK56713.1 - 5.1e-05 23.0 1.2 9.9e-05 22.1 1.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.15 PIK56713.1 - 0.043 13.9 1.0 0.1 12.7 0.6 1.8 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger PHD PF00628.29 PIK56713.1 - 0.44 10.5 2.7 0.84 9.6 2.7 1.4 1 0 0 1 1 1 0 PHD-finger OCRE PF17780.1 PIK56714.1 - 8.2e-16 57.8 14.3 1.5e-15 56.9 14.3 1.5 1 0 0 1 1 1 1 OCRE domain FHA PF00498.26 PIK56714.1 - 3.5e-05 24.1 0.0 8.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK56714.1 - 0.011 16.1 0.2 0.039 14.3 0.0 2.1 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain PhyH PF05721.13 PIK56714.1 - 0.094 13.0 2.3 0.16 12.2 0.0 2.5 1 1 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) AcylCoA_dehyd_C PF12186.8 PIK56714.1 - 0.45 10.7 4.5 0.23 11.6 0.7 2.4 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal Ank_2 PF12796.7 PIK56715.1 - 2.5e-12 47.2 0.0 5.6e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK56715.1 - 7.5e-12 45.2 0.1 5.8e-05 23.3 0.0 4.5 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK56715.1 - 1.9e-11 44.2 0.0 4e-09 36.8 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) LEM PF03020.15 PIK56715.1 - 4.4e-10 39.0 0.5 1e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 LEM domain Ank PF00023.30 PIK56715.1 - 9.4e-10 38.5 0.0 0.005 17.2 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 PIK56715.1 - 2e-08 33.9 0.1 0.0066 16.9 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Abhydrolase_1 PF00561.20 PIK56716.1 - 4.5e-16 59.3 0.0 9.8e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK56716.1 - 1.7e-12 47.2 0.0 6.9e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK56716.1 - 6.1e-12 46.6 0.0 9e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 PIK56716.1 - 0.00078 19.2 0.0 0.0023 17.6 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Thioesterase PF00975.20 PIK56716.1 - 0.0014 18.7 0.0 0.097 12.8 0.0 2.1 2 0 0 2 2 2 1 Thioesterase domain DLH PF01738.18 PIK56716.1 - 0.0035 16.9 0.0 0.45 10.0 0.0 2.4 2 1 0 2 2 2 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 PIK56716.1 - 0.026 14.1 0.0 0.57 9.7 0.0 2.0 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 PIK56716.1 - 0.032 14.1 0.0 2.9 7.7 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_8 PF06259.12 PIK56716.1 - 0.04 13.6 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Peptidase_S15 PF02129.18 PIK56716.1 - 0.051 13.2 0.0 0.91 9.1 0.0 2.3 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S10 PF00450.22 PIK56716.1 - 0.16 11.4 0.3 3.4 7.0 0.1 2.2 2 1 0 2 2 2 0 Serine carboxypeptidase Kelch_1 PF01344.25 PIK56717.1 - 1.3e-41 140.0 1.5 4.4e-11 42.2 0.0 5.6 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 PIK56717.1 - 1.8e-31 107.4 5.5 6.5e-10 38.9 0.0 5.9 2 1 3 5 5 5 5 Kelch motif Kelch_3 PF13415.6 PIK56717.1 - 2.3e-19 69.2 4.2 1.5e-05 25.1 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK56717.1 - 2e-18 66.1 0.1 0.00013 21.9 0.0 4.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK56717.1 - 1.9e-16 59.6 0.0 9.6e-07 28.7 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 PIK56717.1 - 3.1e-14 52.3 4.4 0.006 16.5 0.0 5.6 4 2 1 5 5 5 4 Kelch motif MFS_1 PF07690.16 PIK56718.1 - 1.1e-37 129.8 31.8 1.1e-37 129.8 31.8 2.5 2 1 1 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK56718.1 - 3.8e-08 32.6 22.3 5.3e-06 25.6 2.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 PIK56718.1 - 0.05 11.9 16.4 0.02 13.2 2.0 3.0 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 PIK56718.1 - 0.061 11.7 16.8 0.12 10.7 16.4 1.6 1 1 0 1 1 1 0 Transmembrane secretion effector TssN PF17555.2 PIK56718.1 - 8.9 5.6 14.3 4.6 6.5 3.5 2.5 2 1 0 2 2 2 0 Type VI secretion system, TssN Forkhead PF00250.18 PIK56719.1 - 1.3e-37 127.9 0.0 2.1e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Astacin PF01400.24 PIK56720.1 - 1.9e-64 216.8 0.3 2.5e-64 216.4 0.3 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56720.1 - 2.2e-07 31.3 8.5 2.2e-07 31.3 8.5 2.6 2 0 0 2 2 2 1 ShK domain-like Peptidase_M11 PF05548.11 PIK56720.1 - 0.017 14.3 0.1 0.027 13.6 0.1 1.4 1 0 0 1 1 1 0 Gametolysin peptidase M11 Astacin PF01400.24 PIK56721.1 - 4.7e-51 173.1 0.0 7.8e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56721.1 - 2.6e-07 31.0 8.9 4.7e-07 30.2 8.9 1.4 1 0 0 1 1 1 1 ShK domain-like ShK PF01549.24 PIK56722.1 - 3.6e-08 33.8 9.7 3.6e-08 33.8 9.7 2.1 2 0 0 2 2 2 1 ShK domain-like Astacin PF01400.24 PIK56723.1 - 2.4e-43 148.0 1.0 3.1e-43 147.6 1.0 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56723.1 - 1.2e-07 32.1 8.9 3.1e-07 30.8 8.9 1.7 1 0 0 1 1 1 1 ShK domain-like Astacin PF01400.24 PIK56725.1 - 7.2e-34 117.1 2.6 1e-33 116.6 2.6 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56725.1 - 2.1e-15 56.9 30.7 5.2e-08 33.3 11.4 2.5 3 0 0 3 3 3 2 ShK domain-like zf-CCCH PF00642.24 PIK56725.1 - 0.0024 17.7 0.2 1.6 8.7 0.0 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Astacin PF01400.24 PIK56726.1 - 3.3e-63 212.8 0.3 5.4e-63 212.1 0.3 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56726.1 - 1.7e-12 47.7 21.9 5.1e-07 30.1 8.9 2.6 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 PIK56726.1 - 0.012 15.5 2.0 4.1 7.4 0.0 3.4 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Astacin PF01400.24 PIK56728.1 - 2.4e-43 148.0 0.0 4.5e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56728.1 - 3.9e-12 46.5 18.6 4.8e-07 30.2 8.9 2.5 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 PIK56728.1 - 0.033 14.1 1.7 3.8 7.5 0.0 2.9 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ShK PF01549.24 PIK56729.1 - 5.6e-08 33.2 9.8 5.6e-08 33.2 9.8 2.4 2 0 0 2 2 2 1 ShK domain-like Astacin PF01400.24 PIK56730.1 - 7.1e-31 107.3 0.0 1.4e-24 86.8 0.0 2.2 1 1 1 2 2 2 2 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56730.1 - 1.1e-07 32.3 8.9 2.7e-07 31.0 8.9 1.7 1 0 0 1 1 1 1 ShK domain-like Astacin PF01400.24 PIK56732.1 - 7.2e-34 117.1 2.6 1e-33 116.6 2.6 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56732.1 - 2.6e-15 56.7 31.1 5.2e-08 33.3 11.4 2.6 3 0 0 3 3 3 2 ShK domain-like zf-CCCH PF00642.24 PIK56732.1 - 0.0024 17.7 0.2 1.6 8.7 0.0 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ShK PF01549.24 PIK56733.1 - 0.00032 21.1 1.9 0.00032 21.1 1.9 2.2 2 0 0 2 2 2 1 ShK domain-like Astacin PF01400.24 PIK56734.1 - 2.3e-40 138.3 0.0 3.8e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56734.1 - 2.3e-15 56.9 28.3 1.1e-07 32.2 11.4 2.3 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 PIK56734.1 - 0.011 15.6 1.8 3.1 7.8 0.0 3.2 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2407_C PF13373.6 PIK56734.1 - 0.11 12.6 0.2 0.98 9.6 0.0 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain Astacin PF01400.24 PIK56736.1 - 1.4e-56 191.1 0.1 2.3e-56 190.5 0.1 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M11 PF05548.11 PIK56736.1 - 0.025 13.7 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Gametolysin peptidase M11 Astacin PF01400.24 PIK56737.1 - 2.5e-47 161.0 0.1 5.4e-41 140.3 0.1 2.4 1 1 1 2 2 2 2 Astacin (Peptidase family M12A) ShK PF01549.24 PIK56737.1 - 3e-15 56.5 28.5 1.3e-07 32.0 11.4 2.6 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 PIK56737.1 - 0.011 15.7 2.5 3 7.9 0.0 3.5 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SRCR PF00530.18 PIK56738.1 - 3.6e-46 155.7 11.7 1.7e-25 89.4 2.5 2.4 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain EGF PF00008.27 PIK56738.1 - 3.2e-09 36.9 6.3 1e-08 35.3 6.3 2.0 1 0 0 1 1 1 1 EGF-like domain SRCR_2 PF15494.6 PIK56738.1 - 2.3e-07 31.3 7.3 0.0041 17.6 1.2 2.9 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain hEGF PF12661.7 PIK56738.1 - 0.013 16.1 3.3 0.013 16.1 3.3 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF DUF5536 PF17688.1 PIK56738.1 - 0.19 11.6 2.2 0.79 9.6 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5536) EGF_MSP1_1 PF12946.7 PIK56738.1 - 5.9 7.0 9.6 0.91 9.6 5.1 2.1 2 0 0 2 2 2 0 MSP1 EGF domain 1 7tm_1 PF00001.21 PIK56739.1 - 1.5e-30 106.4 7.6 1.8e-30 106.2 7.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56739.1 - 5.5e-05 22.7 5.9 7.2e-05 22.3 5.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 PIK56740.1 - 2e-25 89.6 4.6 2.6e-25 89.2 4.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56740.1 - 5.5e-06 25.9 1.5 6.9e-06 25.6 1.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK56740.1 - 0.00023 20.9 9.6 0.00026 20.7 9.6 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Paramyxo_NS_C PF02725.14 PIK56740.1 - 0.078 13.1 0.7 0.27 11.3 0.1 1.9 2 0 0 2 2 2 0 Non-structural protein C EGF_CA PF07645.15 PIK56741.1 - 3.1e-261 843.5 710.5 1.4e-09 38.0 4.5 48.2 49 1 2 51 51 51 41 Calcium-binding EGF domain cEGF PF12662.7 PIK56741.1 - 1.1e-175 568.8 446.1 4.9e-08 32.8 0.5 52.5 52 0 0 52 52 52 46 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK56741.1 - 5e-91 298.7 634.9 1.4e-07 31.7 9.7 50.9 45 4 4 49 49 49 40 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK56741.1 - 7.8e-82 269.1 614.7 0.00013 22.2 5.0 47.0 48 0 0 48 48 48 40 EGF-like domain TB PF00683.17 PIK56741.1 - 7.1e-80 262.5 139.8 2.5e-13 49.5 10.2 11.4 11 0 0 11 11 11 9 TB domain hEGF PF12661.7 PIK56741.1 - 4.5e-40 134.9 639.7 0.00071 20.1 7.6 50.0 52 0 0 52 52 52 37 Human growth factor-like EGF EGF_3 PF12947.7 PIK56741.1 - 1.5e-29 101.9 549.3 6.6e-09 35.8 8.3 45.5 41 3 3 44 44 44 27 EGF domain Fibrillin_U_N PF18193.1 PIK56741.1 - 1.8e-09 37.6 3.9 1.8e-09 37.6 3.9 7.4 7 0 0 7 7 7 1 Fibrillin 1 unique N-terminal domain EGF_MSP1_1 PF12946.7 PIK56741.1 - 2.4e-05 24.3 5.6 2.4e-05 24.3 5.6 37.9 38 2 2 40 40 40 12 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK56741.1 - 0.00023 21.4 446.4 0.00081 19.6 4.5 41.1 38 3 3 41 41 41 24 Pvs28 EGF domain QVR PF17064.5 PIK56742.1 - 0.097 12.9 15.5 0.23 11.7 15.3 1.7 1 1 0 1 1 1 0 Sleepless protein Toxin_TOLIP PF00087.21 PIK56742.1 - 0.64 10.3 16.1 1.1 9.6 16.0 1.6 1 1 0 1 1 1 0 Snake toxin and toxin-like protein HAUS6_N PF14661.6 PIK56744.1 - 4.4e-59 199.8 0.2 1e-58 198.6 0.2 1.6 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus HycA_repressor PF11046.8 PIK56744.1 - 0.16 12.1 0.2 0.37 11.0 0.2 1.5 1 0 0 1 1 1 0 Transcriptional repressor of hyc and hyp operons DUF1674 PF07896.12 PIK56745.1 - 3.2e-08 33.9 5.7 3.2e-08 33.9 5.7 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1674) I-set PF07679.16 PIK56746.1 - 8.2e-61 202.1 0.6 2e-18 66.2 0.1 4.3 3 1 1 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK56746.1 - 7.1e-54 180.3 5.0 1.3e-13 51.3 0.1 4.4 3 1 1 4 4 4 4 Immunoglobulin domain SRCR PF00530.18 PIK56746.1 - 1.1e-45 154.2 4.4 7.5e-26 90.6 0.9 3.8 3 0 0 3 3 2 2 Scavenger receptor cysteine-rich domain Ig_2 PF13895.6 PIK56746.1 - 1.4e-42 143.9 2.4 2.7e-10 40.4 0.0 4.6 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK56746.1 - 8.2e-35 118.9 2.6 1.7e-08 34.5 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK56746.1 - 4.8e-16 58.9 8.3 0.00038 20.6 0.6 6.2 3 3 0 3 3 3 3 Immunoglobulin V-set domain Furin-like_2 PF15913.5 PIK56746.1 - 2.7e-11 43.6 65.0 1.5e-05 25.1 14.7 4.7 3 2 1 4 4 3 3 Furin-like repeat, cysteine-rich Ig_6 PF18452.1 PIK56746.1 - 2.7e-09 36.4 0.0 0.17 11.5 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK56746.1 - 1.2e-08 34.9 3.0 0.057 13.5 0.0 4.4 3 1 1 4 4 4 2 CD80-like C2-set immunoglobulin domain SRCR_2 PF15494.6 PIK56746.1 - 1e-07 32.4 10.4 0.0011 19.5 0.1 3.9 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain VSP PF03302.13 PIK56746.1 - 6.9e-07 28.5 66.1 0.00087 18.3 8.0 4.5 3 1 1 4 4 4 4 Giardia variant-specific surface protein Izumo-Ig PF16706.5 PIK56746.1 - 4.5e-05 23.4 0.1 4.8 7.3 0.0 3.6 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain GF_recep_IV PF14843.6 PIK56746.1 - 0.00048 19.9 20.2 0.00048 19.9 20.2 4.5 3 1 1 4 4 4 2 Growth factor receptor domain IV Furin-like PF00757.20 PIK56746.1 - 7.5 6.4 73.6 2.8 7.8 9.2 5.1 3 2 1 4 4 4 0 Furin-like cysteine rich region zf-CCHC PF00098.23 PIK56748.1 - 4.5e-09 36.0 14.2 3.2e-05 23.8 0.7 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK56748.1 - 0.015 15.1 2.6 0.015 15.1 2.6 3.2 3 1 1 4 4 4 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK56748.1 - 0.31 11.0 11.9 1.3 9.0 2.7 2.9 1 1 1 2 2 2 0 Zinc knuckle IBR PF01485.21 PIK56748.1 - 0.64 10.3 14.6 1.6 9.0 14.6 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-CCHC_4 PF14392.6 PIK56748.1 - 0.96 9.2 12.9 0.36 10.6 0.3 3.0 1 1 2 3 3 3 0 Zinc knuckle CPSF100_C PF13299.6 PIK56748.1 - 0.99 9.6 10.6 1.4 9.0 10.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CxC3 PF18804.1 PIK56748.1 - 2.3 8.1 7.5 5 7.0 7.6 1.6 1 1 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases CDC45 PF02724.14 PIK56748.1 - 3.8 5.7 12.6 4.2 5.5 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 PIK56748.1 - 4.5 6.0 7.3 4.8 5.9 7.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Integrase_H2C2 PF17921.1 PIK56749.1 - 3e-11 43.3 0.0 5.2e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK56749.1 - 0.006 16.8 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 PIK56750.1 - 7.5e-06 26.5 0.0 1.4e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK56750.1 - 1.3e-05 25.6 0.0 2.4e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 PIK56750.1 - 0.031 14.1 0.2 3.6 7.4 0.0 2.2 1 1 1 2 2 2 0 Aspartyl protease Dor1 PF04124.12 PIK56751.1 - 0.053 12.2 0.0 0.077 11.7 0.0 1.2 1 0 0 1 1 1 0 Dor1-like family O-FucT PF10250.9 PIK56752.1 - 8.6e-65 219.6 0.0 1e-64 219.4 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase AKAP7_NLS PF10469.9 PIK56753.1 - 4e-37 128.1 0.1 6.1e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 PIK56753.1 - 1.8e-05 24.7 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 PIK56753.1 - 0.015 15.5 0.0 0.17 12.1 0.0 2.3 2 0 0 2 2 2 0 LigT like Phosphoesterase Corona_NS2A PF05213.12 PIK56753.1 - 0.04 13.3 0.0 0.08 12.3 0.0 1.4 1 1 0 1 1 1 0 Coronavirus NS2A protein Rad60-SLD_2 PF13881.6 PIK56753.1 - 0.12 12.5 0.1 0.4 10.8 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DcpS_C PF11969.8 PIK56754.1 - 1.9e-10 41.2 0.0 1.9e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 PIK56754.1 - 1.5e-05 25.6 0.0 1.5e-05 25.6 0.0 1.0 1 0 0 1 1 1 1 HIT domain SE PF08491.10 PIK56755.1 - 6.4e-40 136.9 0.0 8.4e-40 136.5 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 PIK56755.1 - 4.6e-12 45.9 0.0 6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 PIK56755.1 - 3.3e-10 40.1 0.1 0.00042 20.0 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK56755.1 - 7.4e-05 22.9 0.3 0.00016 21.8 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 PIK56755.1 - 0.00049 19.3 1.2 0.26 10.3 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 PIK56755.1 - 0.00074 20.0 0.1 0.0069 16.9 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 PIK56755.1 - 0.0025 16.7 0.9 0.37 9.6 0.3 2.1 1 1 0 2 2 2 2 Tryptophan halogenase ApbA PF02558.16 PIK56755.1 - 0.0044 16.7 0.1 0.0096 15.6 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 PIK56755.1 - 0.0051 16.1 0.1 0.012 14.8 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 PIK56755.1 - 0.0056 16.9 0.4 0.019 15.2 0.1 1.9 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_2 PF03446.15 PIK56755.1 - 0.0062 16.7 0.2 0.067 13.4 0.0 2.1 1 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 PIK56755.1 - 0.0081 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 PIK56755.1 - 0.0097 15.8 0.1 0.017 15.1 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 PIK56755.1 - 0.015 15.6 0.2 0.034 14.4 0.2 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 PIK56755.1 - 0.025 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 PIK56755.1 - 0.082 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 PIK56755.1 - 0.14 11.2 1.8 0.55 9.3 1.8 1.8 1 1 0 1 1 1 0 Glucose inhibited division protein A MORN PF02493.20 PIK56756.1 - 9.5e-43 141.6 57.2 9.3e-06 25.2 0.3 9.6 9 0 0 9 9 9 9 MORN repeat CobU PF02283.16 PIK56757.1 - 0.025 14.2 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Phage_int_SAM_4 PF13495.6 PIK56759.1 - 0.011 16.2 0.0 0.025 15.1 0.0 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK56759.1 - 0.017 14.9 0.0 0.041 13.7 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family Phage_int_SAM_1 PF02899.17 PIK56759.1 - 0.066 13.5 0.1 0.066 13.5 0.1 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RVT_3 PF13456.6 PIK56760.1 - 0.05 13.4 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like EGF PF00008.27 PIK56763.1 - 1.8e-169 549.3 461.7 1.5e-07 31.5 6.1 33.6 33 0 0 33 33 33 32 EGF-like domain hEGF PF12661.7 PIK56763.1 - 3e-58 192.6 366.0 3.3e-05 24.4 5.0 34.7 34 0 0 34 34 34 28 Human growth factor-like EGF EGF_2 PF07974.13 PIK56763.1 - 0.00029 21.1 42.6 0.0019 18.5 11.9 34.1 34 0 0 34 34 34 20 EGF-like domain EGF_3 PF12947.7 PIK56763.1 - 0.014 15.6 1.1 0.014 15.6 1.1 32.8 32 1 1 33 33 33 0 EGF domain VWA_CoxE PF05762.14 PIK56763.1 - 1 8.7 4.1 3.8 6.8 1.4 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PRP1_N PF06424.12 PIK56764.1 - 7.6e-57 191.9 6.2 7.6e-57 191.9 6.2 2.4 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 PIK56764.1 - 1.8e-26 90.5 25.8 0.0044 17.7 0.0 11.8 4 2 8 12 12 12 10 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56764.1 - 2.2e-16 60.1 15.7 5.9e-06 26.7 0.3 7.4 6 2 2 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56764.1 - 9.8e-08 31.6 12.4 0.34 11.2 0.1 6.3 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56764.1 - 1e-07 31.5 12.5 0.37 11.0 0.1 8.1 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56764.1 - 3.2e-07 30.9 1.5 0.00068 20.2 0.0 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK56764.1 - 1.8e-05 24.8 6.0 0.2 12.1 0.1 6.1 5 1 1 6 6 5 1 Tetratricopeptide repeat Suf PF05843.14 PIK56764.1 - 0.00051 20.1 0.7 1.8 8.5 0.0 3.8 4 1 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_1 PF00515.28 PIK56764.1 - 0.0029 17.4 4.8 1.2 9.1 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat ZNRF_3_ecto PF18212.1 PIK56764.1 - 0.032 14.2 0.5 13 5.8 0.0 3.9 3 1 1 4 4 4 0 ZNRF-3 Ectodomain TPR_21 PF09976.9 PIK56764.1 - 0.055 13.2 14.0 0.13 12.0 2.9 4.4 3 1 2 5 5 5 0 Tetratricopeptide repeat-like domain CD225 PF04505.12 PIK56764.1 - 0.22 11.7 3.5 25 5.1 0.1 4.0 4 0 0 4 4 3 0 Interferon-induced transmembrane protein TPR_6 PF13174.6 PIK56764.1 - 0.29 11.9 15.2 55 4.7 0.2 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56764.1 - 0.32 11.3 11.0 30 5.0 0.0 6.3 5 2 0 6 6 6 0 Tetratricopeptide repeat DUF3808 PF10300.9 PIK56764.1 - 0.41 9.3 6.0 1.3 7.6 0.1 3.7 4 1 1 5 5 5 0 Protein of unknown function (DUF3808) SURF2 PF05477.11 PIK56764.1 - 2.5 7.7 7.9 41 3.7 0.0 2.3 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) NPL PF17800.1 PIK56765.1 - 2e-20 73.3 0.1 2e-20 73.3 0.1 2.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain Nse4_C PF08743.10 PIK56765.1 - 5.7 7.3 5.9 50 4.3 4.3 2.7 2 1 0 2 2 2 0 Nse4 C-terminal Cortex-I_coil PF09304.10 PIK56766.1 - 0.21 11.8 3.9 0.59 10.4 3.5 1.9 1 1 1 2 2 2 0 Cortexillin I, coiled coil Het-C PF07217.11 PIK56766.1 - 0.58 8.6 6.6 0.59 8.6 6.6 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Tim54 PF11711.8 PIK56766.1 - 0.73 8.6 10.5 0.82 8.4 10.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Asp-B-Hydro_N PF05279.11 PIK56766.1 - 0.92 9.5 11.0 1.1 9.2 11.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region zf-H2C2_2 PF13465.6 PIK56767.1 - 2.1e-07 31.0 15.4 7.3e-07 29.3 3.9 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK56767.1 - 1.1e-06 28.7 15.5 0.00036 20.8 3.8 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK56767.1 - 1.8e-05 25.2 14.8 0.0013 19.4 3.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK56767.1 - 0.01 15.6 11.4 0.023 14.4 0.8 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CHCC PF10276.9 PIK56767.1 - 0.017 15.1 2.7 0.14 12.2 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger domain C1_4 PF07975.12 PIK56767.1 - 0.034 14.4 2.5 0.071 13.3 2.5 1.5 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 PIK56767.1 - 0.038 13.9 12.7 0.59 10.1 4.6 2.8 2 1 0 2 2 2 0 zinc-finger of a C2HC-type zf-met PF12874.7 PIK56767.1 - 0.042 14.2 0.5 0.042 14.2 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK56767.1 - 0.046 13.7 7.1 1.6 8.8 2.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger PyrI_C PF02748.15 PIK56767.1 - 0.086 12.8 1.3 7.8 6.5 0.1 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK56767.1 - 0.17 12.2 0.3 0.17 12.2 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK56767.1 - 0.22 11.9 6.8 3.4 8.1 0.9 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) C1_2 PF03107.16 PIK56767.1 - 3.6 8.0 9.2 23 5.4 1.7 2.6 1 1 1 2 2 2 0 C1 domain zf-AN1 PF01428.16 PIK56767.1 - 4.7 7.5 8.5 0.63 10.2 1.9 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger zf-H2C2_2 PF13465.6 PIK56768.1 - 6.7e-15 54.7 20.7 1e-07 32.1 4.3 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56768.1 - 2.8e-06 27.7 20.1 0.00098 19.8 1.4 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56768.1 - 2.4e-05 24.5 14.4 0.00014 22.1 1.5 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK56768.1 - 0.0015 18.8 15.5 0.0015 18.7 0.2 2.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK56768.1 - 0.003 17.4 1.9 3.2 7.7 0.5 3.0 3 0 0 3 3 3 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 PIK56768.1 - 0.04 14.0 4.5 0.89 9.7 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger domain zf-AN1 PF01428.16 PIK56768.1 - 0.059 13.6 13.9 0.069 13.3 2.0 3.2 2 1 1 3 3 3 0 AN1-like Zinc finger zf-met PF12874.7 PIK56768.1 - 0.12 12.8 1.0 0.12 12.8 1.0 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK56768.1 - 0.21 11.7 12.2 2.5 8.2 2.0 3.1 1 1 2 3 3 3 0 BED zinc finger zf-C2HC_2 PF13913.6 PIK56768.1 - 0.27 11.2 0.3 0.27 11.2 0.3 3.5 3 1 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 PIK56768.1 - 0.67 10.3 10.2 0.94 9.9 1.2 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Rpr2 PF04032.16 PIK56768.1 - 2 8.8 8.3 18 5.7 8.3 2.2 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-MYST PF17772.1 PIK56768.1 - 3.4 7.4 8.0 5.7 6.6 0.4 2.6 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C4_ClpX PF06689.13 PIK56768.1 - 3.8 7.5 14.5 6.1 6.8 4.6 3.0 2 1 0 2 2 2 0 ClpX C4-type zinc finger FYVE PF01363.21 PIK56768.1 - 8.2 6.7 15.8 2e+02 2.2 15.9 2.3 1 1 0 1 1 1 0 FYVE zinc finger zf-H2C2_2 PF13465.6 PIK56769.1 - 1.5e-11 44.2 24.4 4.3e-06 26.9 4.1 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK56769.1 - 0.0013 19.0 24.3 0.085 13.4 5.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-met PF12874.7 PIK56769.1 - 0.0019 18.5 18.3 0.2 12.1 0.6 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 PIK56769.1 - 0.0033 18.1 25.2 0.22 12.4 4.4 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger DM PF00751.18 PIK56769.1 - 0.008 16.1 3.7 0.008 16.1 3.7 2.6 3 1 0 3 3 3 1 DM DNA binding domain DUF3268 PF11672.8 PIK56769.1 - 0.031 14.6 0.7 0.031 14.6 0.7 1.6 2 0 0 2 2 2 0 zinc-finger-containing domain zf-MYST PF17772.1 PIK56769.1 - 0.12 12.0 14.8 1.5 8.5 0.5 3.2 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 PIK56769.1 - 0.12 12.6 17.2 0.32 11.3 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc-ribbons_6 PF07191.12 PIK56769.1 - 0.58 10.2 8.0 3.4 7.7 2.7 2.7 1 1 2 3 3 3 0 zinc-ribbons UBZ_FAAP20 PF15750.5 PIK56769.1 - 1.6 8.7 7.1 4.9 7.2 0.3 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger Ribosomal_L37ae PF01780.19 PIK56769.1 - 2.3 8.3 9.7 0.33 11.0 3.1 2.3 1 1 1 2 2 2 0 Ribosomal L37ae protein family Zn-ribbon_8 PF09723.10 PIK56769.1 - 5.1 7.3 12.7 4.4 7.5 1.9 3.0 2 1 1 3 3 3 0 Zinc ribbon domain zf-C4_ClpX PF06689.13 PIK56769.1 - 7.2 6.6 7.8 30 4.6 0.5 3.1 3 0 0 3 3 3 0 ClpX C4-type zinc finger zf-H2C2_2 PF13465.6 PIK56770.1 - 8.5e-10 38.6 15.6 8e-06 26.1 0.7 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56770.1 - 8.6e-07 29.3 19.5 0.016 16.0 0.7 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56770.1 - 2.5e-06 27.6 17.7 0.01 16.3 0.7 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-MYST PF17772.1 PIK56770.1 - 0.0022 17.6 8.1 0.22 11.2 2.2 2.8 2 1 1 3 3 3 2 MYST family zinc finger domain zf-AN1 PF01428.16 PIK56770.1 - 0.05 13.8 9.1 0.97 9.7 0.1 3.5 4 0 0 4 4 3 0 AN1-like Zinc finger HalOD2 PF18547.1 PIK56770.1 - 0.052 13.4 2.0 0.068 13.1 0.5 1.9 2 0 0 2 2 2 0 Halobacterial output domain 2 zf-C2H2_6 PF13912.6 PIK56770.1 - 0.061 13.3 12.8 0.12 12.5 1.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK56770.1 - 0.063 13.0 0.1 0.063 13.0 0.1 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn_Tnp_IS91 PF14319.6 PIK56770.1 - 0.1 12.7 0.8 0.1 12.7 0.8 2.2 1 1 1 2 2 2 0 Transposase zinc-binding domain DUF2688 PF10892.8 PIK56770.1 - 0.16 11.5 1.7 9.1 5.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) Zn_Tnp_IS1595 PF12760.7 PIK56770.1 - 0.36 10.8 11.4 1.1 9.2 5.6 2.7 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-CHY PF05495.12 PIK56770.1 - 0.41 11.2 11.4 7.2 7.2 11.5 2.1 1 1 0 1 1 1 0 CHY zinc finger Endonuclease_7 PF02945.15 PIK56770.1 - 0.44 10.5 5.7 1.1 9.2 5.1 1.9 1 1 0 1 1 1 0 Recombination endonuclease VII zf_UBZ PF18439.1 PIK56770.1 - 0.5 10.0 0.1 0.5 10.0 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 PIK56770.1 - 0.54 10.5 6.1 9 6.6 1.6 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain zf-BED PF02892.15 PIK56770.1 - 0.83 9.7 8.0 5.7 7.0 0.2 3.0 2 1 1 3 3 3 0 BED zinc finger Desulfoferrod_N PF06397.12 PIK56770.1 - 0.84 9.3 7.3 1.3 8.7 0.2 3.2 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain Zn-ribbon_8 PF09723.10 PIK56770.1 - 1.5 9.0 8.6 0.48 10.6 0.6 2.9 3 0 0 3 3 3 0 Zinc ribbon domain PyrI_C PF02748.15 PIK56770.1 - 4 7.4 7.9 1.1 9.3 0.5 2.7 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CCHC_2 PF13696.6 PIK56770.1 - 4.7 7.1 8.2 11 5.9 0.1 3.2 3 0 0 3 3 3 0 Zinc knuckle FYVE PF01363.21 PIK56770.1 - 7.2 6.8 14.7 1.6 8.9 1.3 2.8 1 1 1 2 2 2 0 FYVE zinc finger zf-H2C2_2 PF13465.6 PIK56771.1 - 1.5e-16 60.0 40.9 9.3e-07 29.0 1.4 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK56771.1 - 3.5e-08 33.5 29.1 0.026 14.8 0.0 5.3 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK56771.1 - 6.6e-08 32.8 38.1 0.045 14.6 1.9 6.2 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56771.1 - 2.7e-07 30.7 41.3 0.13 12.7 0.4 6.0 6 0 0 6 6 6 5 Zinc finger, C2H2 type SspN PF08177.11 PIK56771.1 - 0.00062 19.7 0.9 1.2 9.2 0.0 2.8 2 1 0 2 2 2 2 Small acid-soluble spore protein N family zf-C2H2_3rep PF18868.1 PIK56771.1 - 0.0009 19.9 21.6 0.029 15.0 2.3 4.1 1 1 2 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 PIK56771.1 - 0.0011 18.7 16.6 0.6 9.9 0.1 5.1 5 0 0 5 5 5 2 zinc-finger C2H2-type Mut7-C PF01927.16 PIK56771.1 - 0.003 17.7 0.8 0.003 17.7 0.8 3.4 1 1 1 3 3 3 1 Mut7-C RNAse domain zf-C2H2_6 PF13912.6 PIK56771.1 - 0.013 15.5 1.3 0.013 15.5 1.3 5.5 5 1 0 5 5 5 0 C2H2-type zinc finger RC-P840_PscD PF10657.9 PIK56771.1 - 0.098 12.8 0.0 0.45 10.6 0.0 2.0 1 1 1 2 2 2 0 Photosystem P840 reaction centre protein PscD HypA PF01155.19 PIK56771.1 - 0.36 10.8 16.4 27 4.8 1.9 3.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.5 PIK56771.1 - 0.4 11.2 0.2 0.4 11.2 0.2 5.1 3 2 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 PIK56771.1 - 0.59 10.6 0.0 0.59 10.6 0.0 4.8 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-CHCC PF10276.9 PIK56771.1 - 1.2 9.3 10.2 12 6.0 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger domain DUF3268 PF11672.8 PIK56771.1 - 2.4 8.5 14.0 4 7.8 0.6 3.2 3 1 1 4 4 4 0 zinc-finger-containing domain zf-C2H2_2 PF12756.7 PIK56771.1 - 2.5 8.5 29.8 0.18 12.2 2.3 4.9 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 PIK56771.1 - 4.6 7.3 29.1 1.6 8.7 0.3 5.9 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zinc-ribbons_6 PF07191.12 PIK56771.1 - 6.6 6.8 23.1 49 4.0 7.8 4.8 1 1 3 4 4 4 0 zinc-ribbons NosL PF05573.12 PIK56771.1 - 8.4 6.7 6.0 38 4.6 0.1 3.0 4 0 0 4 4 3 0 NosL FYDLN_acid PF09538.10 PIK56771.1 - 9.4 7.0 16.1 28 5.5 3.0 4.2 2 2 1 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-H2C2_2 PF13465.6 PIK56772.1 - 1.6e-12 47.3 12.4 1.1e-08 35.1 0.5 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56772.1 - 4.3e-08 33.3 10.8 0.0016 19.1 0.5 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56772.1 - 1.8e-06 28.0 12.2 0.0091 16.4 0.6 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK56772.1 - 0.00045 20.4 0.7 4.1 7.8 0.0 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding C1_1 PF00130.22 PIK56772.1 - 0.012 15.5 4.2 0.21 11.5 1.5 2.6 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.7 PIK56772.1 - 0.014 15.8 5.7 0.43 11.0 0.1 3.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type LIM PF00412.22 PIK56772.1 - 0.015 15.5 2.7 0.054 13.7 0.2 2.2 1 1 1 2 2 2 0 LIM domain zf-BED PF02892.15 PIK56772.1 - 0.032 14.3 7.0 2.9 8.0 2.9 2.9 1 1 1 2 2 2 0 BED zinc finger C1_4 PF07975.12 PIK56772.1 - 0.036 14.3 2.9 1.9 8.8 3.0 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain DUF4764 PF15961.5 PIK56772.1 - 0.092 11.4 0.5 0.12 11.0 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) PyrI_C PF02748.15 PIK56772.1 - 0.097 12.6 2.3 2.4 8.2 0.1 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 PIK56772.1 - 0.15 12.1 0.4 0.15 12.1 0.4 3.7 3 1 0 3 3 3 0 C2H2-type zinc finger FYVE PF01363.21 PIK56772.1 - 0.18 11.9 12.0 6.6 7.0 0.4 3.1 1 1 1 2 2 2 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 PIK56772.1 - 0.21 11.8 4.1 3.9 7.7 1.8 2.8 2 1 1 3 3 3 0 Zinc ribbon domain Elf1 PF05129.13 PIK56772.1 - 0.66 10.1 5.0 0.33 11.0 0.9 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Zf_RING PF16744.5 PIK56772.1 - 0.72 10.0 4.6 4.5 7.5 0.1 2.9 1 1 1 3 3 3 0 KIAA1045 RING finger C1_2 PF03107.16 PIK56772.1 - 0.85 10.0 7.5 36 4.8 7.5 3.0 1 1 0 1 1 1 0 C1 domain zf-C2H2_11 PF16622.5 PIK56772.1 - 0.91 9.3 8.5 0.21 11.4 0.4 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-FCS PF06467.14 PIK56772.1 - 1.3 9.0 5.6 1.3 9.0 0.8 2.8 1 1 2 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DZR PF12773.7 PIK56772.1 - 1.7 8.8 4.9 11 6.2 4.9 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-AN1 PF01428.16 PIK56772.1 - 2.9 8.1 7.2 7.7 6.8 0.3 3.1 3 0 0 3 3 3 0 AN1-like Zinc finger zf-H2C2_2 PF13465.6 PIK56773.1 - 8.2e-17 60.8 33.9 9.4e-08 32.2 3.6 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56773.1 - 6.4e-11 42.1 24.1 0.0026 18.5 1.9 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56773.1 - 2.7e-09 36.9 27.2 0.0066 16.9 2.5 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-AN1 PF01428.16 PIK56773.1 - 0.00097 19.3 14.1 1.2 9.3 0.6 4.2 4 0 0 4 4 4 2 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 PIK56773.1 - 0.0037 17.4 9.8 0.48 10.6 0.1 3.8 3 1 1 4 4 4 2 Zinc ribbon domain zf-C2H2_jaz PF12171.8 PIK56773.1 - 0.0037 17.5 15.1 1.3 9.4 0.6 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding C1_1 PF00130.22 PIK56773.1 - 0.025 14.4 11.9 0.38 10.7 0.7 3.2 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 PIK56773.1 - 0.032 14.3 10.2 2.6 8.2 0.2 4.0 1 1 2 4 4 4 0 KIAA1045 RING finger DUF3268 PF11672.8 PIK56773.1 - 0.039 14.3 5.9 1.7 9.0 0.2 3.0 1 1 2 3 3 3 0 zinc-finger-containing domain PyrI_C PF02748.15 PIK56773.1 - 0.077 12.9 8.1 13 5.8 0.4 4.1 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 PIK56773.1 - 0.097 13.1 12.9 4.9 7.7 0.1 4.3 4 1 0 4 4 4 0 Zinc-finger of C2H2 type FYVE PF01363.21 PIK56773.1 - 0.15 12.2 14.3 0.13 12.4 3.3 2.8 1 1 1 2 2 2 0 FYVE zinc finger C1_4 PF07975.12 PIK56773.1 - 0.23 11.7 10.0 1.9 8.7 0.2 3.2 1 1 2 3 3 3 0 TFIIH C1-like domain zf-FCS PF06467.14 PIK56773.1 - 0.34 10.9 15.4 5.1 7.1 6.1 4.1 3 1 1 4 4 4 0 MYM-type Zinc finger with FCS sequence motif zinc_ribbon_15 PF17032.5 PIK56773.1 - 0.6 10.9 6.1 8.1 7.3 3.1 2.6 1 1 2 3 3 3 0 zinc-ribbon family zf-BED PF02892.15 PIK56773.1 - 0.6 10.2 16.4 13 5.9 0.1 4.3 1 1 3 4 4 4 0 BED zinc finger zf-DNA_Pol PF08996.10 PIK56773.1 - 0.84 9.4 4.5 0.27 11.0 0.6 1.9 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zf-trcl PF13451.6 PIK56773.1 - 1.7 8.6 0.0 1.7 8.6 0.0 3.8 3 1 0 3 3 3 0 Probable zinc-ribbon domain zf-C2H2_3rep PF18868.1 PIK56773.1 - 1.7 9.3 13.3 16 6.2 0.1 3.9 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 PIK56773.1 - 1.9 8.8 14.5 2 8.8 0.7 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.13 PIK56773.1 - 2.9 8.0 12.8 0.74 9.9 2.8 3.1 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like zf-LYAR PF08790.11 PIK56773.1 - 3.7 7.6 8.2 8.8 6.3 0.1 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger PHD PF00628.29 PIK56773.1 - 4.9 7.1 9.5 37 4.3 6.7 2.9 2 1 0 2 2 2 0 PHD-finger DZR PF12773.7 PIK56773.1 - 5.8 7.0 11.9 1.8e+03 -0.9 11.9 2.8 1 1 0 1 1 1 0 Double zinc ribbon GFA PF04828.14 PIK56773.1 - 8.5 6.8 8.7 19 5.7 1.3 3.2 1 1 3 4 4 4 0 Glutathione-dependent formaldehyde-activating enzyme zf-HIT PF04438.16 PIK56773.1 - 9.3 6.2 18.7 1.8 8.5 0.9 4.0 4 0 0 4 4 4 0 HIT zinc finger HNH_5 PF14279.6 PIK56773.1 - 10 6.1 9.9 71 3.4 0.1 4.1 4 0 0 4 4 4 0 HNH endonuclease zf-C2H2 PF00096.26 PIK56774.1 - 2.1e-15 56.2 43.7 0.00012 22.3 1.8 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK56774.1 - 8.6e-14 51.1 38.6 0.0042 17.8 1.1 6.4 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK56774.1 - 1.2e-11 44.5 51.3 2.6e-07 30.8 1.3 7.2 7 0 0 7 7 7 3 Zinc-finger double domain DUF3268 PF11672.8 PIK56774.1 - 7.1e-05 23.1 12.5 0.11 12.9 0.5 4.0 2 2 2 4 4 4 2 zinc-finger-containing domain C1_1 PF00130.22 PIK56774.1 - 0.00021 21.1 12.5 0.14 12.1 0.1 4.4 2 2 1 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_3rep PF18868.1 PIK56774.1 - 0.0099 16.6 20.8 0.58 10.8 0.1 5.8 2 2 4 6 6 6 2 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 PIK56774.1 - 0.02 15.3 16.6 0.031 14.7 0.4 4.8 5 0 0 5 5 4 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK56774.1 - 0.062 13.2 15.5 12 5.9 0.0 5.9 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK56774.1 - 0.083 13.2 21.1 9.1 6.7 0.4 5.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK56774.1 - 0.095 12.7 32.2 1.1 9.3 0.3 6.2 2 2 4 6 6 6 0 BED zinc finger FYDLN_acid PF09538.10 PIK56774.1 - 0.2 12.4 7.9 10 6.9 0.0 4.3 4 2 1 5 5 5 0 Protein of unknown function (FYDLN_acid) Elf1 PF05129.13 PIK56774.1 - 0.57 10.3 13.2 0.29 11.2 1.3 4.1 2 2 1 4 4 4 0 Transcription elongation factor Elf1 like zf-trcl PF13451.6 PIK56774.1 - 0.58 10.1 14.2 3.3 7.7 0.3 5.4 6 0 0 6 6 6 0 Probable zinc-ribbon domain DZR PF12773.7 PIK56774.1 - 1.8 8.6 20.1 5.6 7.1 5.6 3.7 2 2 0 2 2 2 0 Double zinc ribbon FYVE PF01363.21 PIK56774.1 - 2.2 8.5 29.2 11 6.3 9.5 4.4 2 2 1 3 3 3 0 FYVE zinc finger FYVE_2 PF02318.16 PIK56774.1 - 2.4 8.4 8.3 0.32 11.2 0.4 2.5 2 1 0 2 2 2 0 FYVE-type zinc finger zf-AN1 PF01428.16 PIK56774.1 - 3.8 7.8 26.4 19 5.5 0.1 6.3 6 1 0 6 6 6 0 AN1-like Zinc finger zf-CHCC PF10276.9 PIK56774.1 - 4.6 7.4 27.0 3 8.0 0.3 5.7 6 0 0 6 6 6 0 Zinc-finger domain Zf_RING PF16744.5 PIK56774.1 - 5.8 7.1 18.8 2 8.6 0.2 4.8 2 2 3 5 5 5 0 KIAA1045 RING finger zf-C2H2_4 PF13894.6 PIK56775.1 - 1.8e-07 31.4 35.8 0.024 15.4 0.5 5.1 3 1 2 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK56775.1 - 6.5e-07 29.5 35.2 0.022 15.2 0.3 5.3 4 1 1 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK56775.1 - 0.00062 20.1 29.5 0.0012 19.1 3.1 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK56775.1 - 0.0011 19.2 2.4 0.0011 19.2 2.4 4.4 4 2 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK56775.1 - 0.002 18.4 2.0 0.002 18.4 2.0 4.5 4 1 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK56775.1 - 0.0067 16.4 0.9 0.0067 16.4 0.9 5.9 4 1 1 5 5 5 1 C2H2-type zinc finger Prok-RING_1 PF14446.6 PIK56775.1 - 0.11 12.4 13.0 3.3 7.7 0.1 3.9 4 1 0 4 4 4 0 Prokaryotic RING finger family 1 Spt46 PF17734.1 PIK56775.1 - 0.25 11.1 4.1 0.14 12.0 2.1 1.6 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 zinc_ribbon_5 PF13719.6 PIK56775.1 - 0.88 9.4 15.4 2.3 8.0 3.0 4.0 3 1 0 3 3 3 0 zinc-ribbon domain NicO PF03824.16 PIK56775.1 - 1.2 8.5 2.9 1.5 8.1 2.9 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein zf_UBZ PF18439.1 PIK56775.1 - 2 8.1 13.4 0.92 9.2 0.2 4.0 4 1 1 5 5 5 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 PIK56775.1 - 2.3 8.3 12.6 4.2 7.4 7.2 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met2 PF12907.7 PIK56775.1 - 2.9 8.1 20.9 1.1 9.4 1.1 3.5 3 2 0 3 3 3 0 Zinc-binding Zn-ribbon_8 PF09723.10 PIK56775.1 - 3 8.0 16.3 0.17 12.1 1.7 3.4 2 2 1 3 3 3 0 Zinc ribbon domain zf-Di19 PF05605.12 PIK56775.1 - 4.1 7.8 23.0 0.73 10.2 5.7 3.2 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 PIK56775.1 - 5.3 7.0 24.4 1.5 8.8 4.7 4.5 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Cript PF10235.9 PIK56775.1 - 8.3 7.1 12.1 2.9 8.5 8.2 2.1 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT zf-BED PF02892.15 PIK56775.1 - 9.6 6.3 22.9 2 8.5 1.0 3.9 1 1 3 4 4 4 0 BED zinc finger zf-C2H2_2 PF12756.7 PIK56775.1 - 9.9 6.6 22.5 15 6.0 2.3 3.5 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) rve PF00665.26 PIK56776.1 - 1.4e-20 73.7 0.0 2.2e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56776.1 - 3.4e-18 65.5 0.6 5.8e-18 64.8 0.6 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK56776.1 - 0.00046 20.4 0.8 0.00083 19.5 0.8 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK56776.1 - 0.036 13.8 0.0 0.073 12.9 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Cytochrome_CBB3 PF13442.6 PIK56776.1 - 0.076 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III RVT_1 PF00078.27 PIK56777.1 - 2.9e-06 27.0 0.0 5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Catalase PF00199.19 PIK56778.1 - 2e-128 428.8 4.9 5.4e-90 302.3 3.6 2.7 1 1 1 2 2 2 2 Catalase Catalase-rel PF06628.12 PIK56778.1 - 3.8e-21 75.1 0.1 8.4e-21 74.0 0.1 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive GSK-3_bind PF05350.12 PIK56778.1 - 0.14 11.5 0.2 0.22 10.8 0.2 1.2 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding Arm PF00514.23 PIK56779.1 - 0.00048 20.1 0.2 0.62 10.2 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat C2 PF00168.30 PIK56780.1 - 3.7e-57 191.0 0.3 1e-30 106.0 0.0 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 PIK56780.1 - 0.0001 21.9 0.0 0.033 13.7 0.0 2.3 2 0 0 2 2 2 2 CEP76 C2 domain PI3K_C2 PF00792.24 PIK56780.1 - 0.0031 17.4 0.0 0.024 14.5 0.0 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 DOCK-C2 PF14429.6 PIK56780.1 - 0.049 13.4 0.3 3.4 7.4 0.0 2.1 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins TMEM52 PF14979.6 PIK56781.1 - 0.0012 18.8 4.7 0.0012 18.8 4.7 1.0 1 0 0 1 1 1 1 Transmembrane 52 EphA2_TM PF14575.6 PIK56781.1 - 0.021 15.7 0.0 0.024 15.5 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_C_2 PF16492.5 PIK56781.1 - 0.023 15.4 0.0 0.023 15.4 0.0 1.1 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Mucin PF01456.17 PIK56781.1 - 0.029 14.4 2.7 0.032 14.2 2.7 1.0 1 0 0 1 1 1 0 Mucin-like glycoprotein ETRAMP PF09716.10 PIK56781.1 - 0.029 14.4 0.2 0.032 14.3 0.2 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) HEV_ORF1 PF02444.16 PIK56781.1 - 0.13 12.8 2.7 0.13 12.8 2.7 1.1 1 0 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) Vpu PF00558.19 PIK56781.1 - 0.2 11.4 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 Vpu protein UPF0560 PF10577.9 PIK56781.1 - 0.26 9.8 4.5 0.25 9.8 4.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 ATP1G1_PLM_MAT8 PF02038.16 PIK56781.1 - 2.5 7.6 9.3 1.1 8.8 7.0 1.5 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Gal-3-0_sulfotr PF06990.11 PIK56782.1 - 2.5e-18 66.2 1.9 3e-18 65.9 1.9 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK56782.1 - 0.0003 20.8 0.6 0.0005 20.1 0.6 1.4 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK56782.1 - 0.00046 19.8 0.1 0.0011 18.5 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain OppC_N PF12911.7 PIK56782.1 - 0.068 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C NPL PF17800.1 PIK56783.1 - 5.4e-18 65.5 1.1 1.5e-17 64.1 0.0 2.2 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-C2H2 PF00096.26 PIK56783.1 - 3.7e-09 36.5 19.4 0.0011 19.3 1.4 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK56783.1 - 1.9e-06 28.1 1.2 1.9e-06 28.1 1.2 3.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56783.1 - 1.7e-05 25.2 17.5 0.089 13.7 0.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 PIK56783.1 - 0.0033 17.8 6.3 0.14 12.6 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK56783.1 - 0.012 15.9 8.2 0.29 11.5 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK56783.1 - 0.012 15.5 0.6 5.3 7.0 0.0 2.6 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 PIK56783.1 - 0.041 13.6 9.1 2.7 7.8 0.6 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 PIK56783.1 - 0.12 12.4 0.4 0.12 12.4 0.4 3.2 1 1 2 3 3 3 0 BED zinc finger zf-C2H2_6 PF13912.6 PIK56783.1 - 0.16 12.1 3.5 0.14 12.2 0.7 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger DUF3268 PF11672.8 PIK56783.1 - 0.19 12.1 1.6 0.24 11.7 0.3 1.8 1 1 1 2 2 2 0 zinc-finger-containing domain TF_Zn_Ribbon PF08271.12 PIK56783.1 - 0.31 10.6 3.3 7.9 6.1 0.0 3.0 2 1 0 2 2 2 0 TFIIB zinc-binding zf-C2HE PF16278.5 PIK56783.1 - 0.53 10.8 10.4 0.23 11.9 0.6 3.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger SDA1 PF05285.12 PIK56783.1 - 1.2 8.5 9.4 1.7 8.0 9.4 1.1 1 0 0 1 1 1 0 SDA1 zf-Di19 PF05605.12 PIK56783.1 - 1.4 9.2 4.8 21 5.5 0.2 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 PIK56783.1 - 1.7 8.9 7.0 6 7.1 0.3 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger E2F_TDP PF02319.20 PIK56784.1 - 9.2e-39 131.4 0.3 1.4e-18 66.7 0.0 2.6 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 PIK56784.1 - 0.00049 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RYDR_ITPR PF01365.21 PIK56784.1 - 0.059 12.8 0.3 0.11 11.9 0.3 1.4 1 0 0 1 1 1 0 RIH domain Spond_N PF06468.13 PIK56785.1 - 2.5e-33 115.8 0.2 3.3e-33 115.5 0.2 1.2 1 0 0 1 1 1 1 Spondin_N Spond_N PF06468.13 PIK56786.1 - 3.5e-22 79.5 0.2 5.3e-22 78.9 0.2 1.2 1 0 0 1 1 1 1 Spondin_N Reeler PF02014.16 PIK56786.1 - 5.7e-13 49.7 0.1 9.1e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 Reeler domain GFO_IDH_MocA PF01408.22 PIK56787.1 - 1e-20 74.8 0.0 1.5e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Rossmann-like PF10727.9 PIK56787.1 - 0.037 13.9 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain RVT_1 PF00078.27 PIK56788.1 - 4.7e-31 108.0 0.1 5.1e-31 107.9 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GFO_IDH_MocA PF01408.22 PIK56789.1 - 2.9e-21 76.5 0.0 4.4e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Ribosomal_L21p PF00829.21 PIK56790.1 - 2.8e-22 78.9 0.2 3.3e-22 78.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein DUF5585 PF17823.1 PIK56791.1 - 3.8e-08 32.8 0.8 3.8e-08 32.8 0.8 3.1 1 1 1 3 3 3 1 Family of unknown function (DUF5585) TRP PF06011.12 PIK56791.1 - 0.047 12.4 2.4 0.11 11.2 2.4 1.8 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel ArfGap PF01412.18 PIK56792.1 - 1.3e-29 102.7 0.5 1.3e-29 102.7 0.5 2.7 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf CH PF00307.31 PIK56793.1 - 1.3e-22 80.0 0.0 5e-22 78.1 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK56793.1 - 1.8e-13 50.1 0.0 3.6e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain FAD_binding_3 PF01494.19 PIK56793.1 - 2.8e-08 33.4 0.1 7.5e-08 32.0 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 PIK56793.1 - 2.9e-06 26.8 0.0 5.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase LIM PF00412.22 PIK56793.1 - 6.9e-06 26.2 6.4 1.4e-05 25.2 6.4 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_2 PF00890.24 PIK56793.1 - 1e-05 24.8 0.1 1.5e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 PIK56793.1 - 1e-05 25.0 0.0 1.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK56793.1 - 6.9e-05 21.7 0.1 0.00012 20.9 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 PIK56793.1 - 0.0007 19.3 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK56793.1 - 0.00076 20.0 0.1 0.0023 18.4 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK56793.1 - 0.00081 19.6 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK56793.1 - 0.0015 17.9 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 PIK56793.1 - 0.0022 17.1 0.0 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 PIK56793.1 - 0.0024 17.3 0.1 0.0057 16.1 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 PIK56793.1 - 0.0035 16.7 0.0 0.008 15.5 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 PIK56793.1 - 0.0075 16.7 0.0 0.022 15.2 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding GIDA PF01134.22 PIK56793.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A CH_2 PF06294.11 PIK56793.1 - 0.021 14.9 0.1 0.069 13.3 0.0 1.9 2 0 0 2 2 2 0 CH-like domain in sperm protein Pox_D5 PF03288.16 PIK56793.1 - 0.05 14.1 3.3 0.62 10.6 0.5 2.9 3 0 0 3 3 2 0 Poxvirus D5 protein-like AAA_23 PF13476.6 PIK56793.1 - 0.93 10.0 6.3 0.46 11.0 2.0 2.2 2 0 0 2 2 2 0 AAA domain Spt5_N PF11942.8 PIK56795.1 - 0.035 15.1 5.7 0.046 14.7 5.7 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 PIK56795.1 - 1.4 7.1 8.2 1.7 6.9 8.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3585 PF12130.8 PIK56796.1 - 6.2e-30 104.1 11.9 6.6e-30 104.0 11.9 1.0 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain CRIC_ras_sig PF10534.9 PIK56796.1 - 0.0066 16.6 0.3 0.0087 16.2 0.3 1.2 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras DUF4287 PF14117.6 PIK56796.1 - 0.25 11.5 0.9 4.3 7.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4287) Fibrinogen_C PF00147.18 PIK56797.1 - 5.6e-101 336.9 15.6 1.4e-61 208.2 10.0 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK56797.1 - 8.5e-06 25.6 4.0 8.5e-06 25.6 4.0 3.4 2 1 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK56797.1 - 9.7e-05 22.5 6.8 9.7e-05 22.5 6.8 3.4 3 0 0 3 3 3 1 EGF domain COLFI PF01410.18 PIK56797.1 - 0.48 9.7 6.3 0.048 13.0 0.6 2.0 2 1 1 3 3 3 0 Fibrillar collagen C-terminal domain EGF_MSP1_1 PF12946.7 PIK56797.1 - 7.7 6.7 18.5 1.5 8.9 4.3 2.8 2 0 0 2 2 2 0 MSP1 EGF domain 1 DUF1955 PF09205.10 PIK56799.1 - 0.037 13.8 0.2 0.054 13.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Peptidase_A17 PF05380.13 PIK56801.1 - 1.4e-16 60.9 0.0 2e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK56801.1 - 0.02 15.0 0.2 0.034 14.2 0.2 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain LRR_8 PF13855.6 PIK56803.1 - 3.4e-22 78.0 3.1 4.8e-14 51.9 0.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 PIK56803.1 - 1e-07 32.0 0.2 4e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK56803.1 - 1.9e-05 24.9 1.9 0.00091 19.6 0.1 3.2 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) zf-RING_2 PF13639.6 PIK56804.1 - 2.4e-07 31.0 9.6 2.4e-07 31.0 9.6 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 PIK56804.1 - 5.6e-07 29.3 8.0 1.7e-06 27.8 8.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK56804.1 - 7.7e-07 28.9 5.9 1.8e-06 27.7 5.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK56804.1 - 7.9e-07 28.9 6.4 2.9e-06 27.1 6.4 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK56804.1 - 2.4e-05 24.1 8.6 2.4e-05 24.1 8.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK56804.1 - 2.8e-05 24.0 6.1 2.8e-05 24.0 6.1 3.0 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK56804.1 - 0.0016 18.2 7.7 0.0063 16.3 7.5 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK56804.1 - 0.003 17.7 8.8 0.003 17.7 8.8 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 PIK56804.1 - 0.013 15.6 2.3 0.013 15.6 2.3 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FTH PF01827.27 PIK56804.1 - 0.17 11.7 0.1 0.31 10.8 0.1 1.3 1 0 0 1 1 1 0 FTH domain zf-RING_6 PF14835.6 PIK56804.1 - 0.41 10.5 4.9 1.6 8.7 4.9 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-ACC PF17848.1 PIK56804.1 - 0.89 9.7 3.2 0.87 9.7 0.9 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain IBR PF01485.21 PIK56804.1 - 1.1 9.5 6.4 0.79 10.0 0.2 2.9 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain zf-Nse PF11789.8 PIK56804.1 - 1.4 8.8 6.5 2.4 8.0 4.7 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 PIK56804.1 - 9.7 6.0 8.3 37 4.2 4.8 3.0 2 1 0 2 2 2 0 RING-like zinc finger Arm PF00514.23 PIK56805.1 - 3.8e-07 29.9 15.2 0.26 11.4 0.3 7.6 7 1 0 7 7 7 3 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 PIK56805.1 - 0.00015 21.8 3.7 0.23 11.4 0.1 3.5 2 1 1 3 3 3 2 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 PIK56805.1 - 0.00052 20.5 2.9 16 6.1 0.0 4.7 3 1 2 5 5 5 2 HEAT-like repeat Proteasom_PSMB PF10508.9 PIK56805.1 - 0.00057 18.5 5.1 0.042 12.4 0.1 3.3 1 1 2 3 3 3 2 Proteasome non-ATPase 26S subunit Atx10homo_assoc PF09759.9 PIK56805.1 - 0.0085 16.1 9.8 0.52 10.4 0.5 3.6 4 0 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain IFRD PF05004.13 PIK56805.1 - 0.017 14.2 3.5 0.42 9.7 2.2 2.9 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Arm_vescicular PF18770.1 PIK56805.1 - 0.058 13.3 0.1 0.28 11.1 0.1 2.2 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor Mnd1 PF03962.15 PIK56806.1 - 3.2e-29 101.0 0.4 9.7e-29 99.4 0.4 1.9 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 PIK56806.1 - 3.5e-26 91.1 3.4 3.5e-26 91.1 3.4 2.4 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Penicillinase_R PF03965.16 PIK56806.1 - 0.00051 20.4 2.5 0.001 19.4 2.5 1.5 1 0 0 1 1 1 1 Penicillinase repressor TLE_N PF03920.15 PIK56806.1 - 0.015 15.4 1.6 0.015 15.4 1.6 2.3 2 1 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain FUR PF01475.19 PIK56806.1 - 0.031 14.4 0.4 0.058 13.5 0.4 1.5 1 1 0 1 1 1 0 Ferric uptake regulator family DUF4364 PF14277.6 PIK56806.1 - 0.047 13.5 1.8 0.19 11.5 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) PRIMA1 PF16101.5 PIK56808.1 - 0.36 10.9 14.5 1.1 9.2 14.5 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF4551 PF15087.6 PIK56808.1 - 7.3 5.3 12.7 10 4.8 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CH PF00307.31 PIK56809.1 - 6.4e-17 61.7 0.3 1.4e-16 60.6 0.3 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain GAS2 PF02187.17 PIK56809.1 - 2.7e-09 37.0 0.0 5.4e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain RRM_1 PF00076.22 PIK56810.1 - 6.1e-20 70.8 0.1 8.6e-20 70.3 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK56810.1 - 0.00033 20.7 0.0 0.00056 20.0 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 PIK56810.1 - 0.0024 17.8 0.0 0.0047 16.9 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 PIK56810.1 - 0.0033 17.2 0.0 0.005 16.7 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 PIK56811.1 - 2.6e-11 43.2 0.0 5e-10 39.1 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) rve PF00665.26 PIK56814.1 - 5.4e-19 68.5 0.0 1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK56814.1 - 3.4e-18 65.5 0.3 6.9e-18 64.5 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK56814.1 - 8.9e-07 29.0 0.2 5.3e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 PIK56814.1 - 0.011 15.5 0.1 0.029 14.2 0.1 1.7 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 PIK56815.1 - 2.7e-07 30.3 0.1 4.8e-07 29.5 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PTH2 PF01981.16 PIK56816.1 - 4.3e-16 59.3 0.2 4.8e-16 59.1 0.2 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Rsm22 PF09243.10 PIK56816.1 - 0.0045 16.3 0.0 0.0047 16.2 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 PTH2 PF01981.16 PIK56817.1 - 1.1e-16 61.2 0.0 1.4e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 GCN5L1 PF06320.13 PIK56818.1 - 0.0042 17.2 0.1 0.0055 16.8 0.1 1.2 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) OmpH PF03938.14 PIK56818.1 - 0.039 14.3 0.3 0.049 14.0 0.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ColG_sub PF18496.1 PIK56818.1 - 0.089 13.0 0.2 0.11 12.7 0.2 1.1 1 0 0 1 1 1 0 Collagenase G catalytic helper subdomain AI-2E_transport PF01594.16 PIK56818.1 - 0.28 10.3 0.1 0.32 10.1 0.1 1.2 1 1 0 1 1 1 0 AI-2E family transporter CAP_GLY PF01302.25 PIK56819.1 - 1.2e-15 57.3 0.2 2.1e-12 46.9 0.0 2.5 2 0 0 2 2 2 2 CAP-Gly domain UCH PF00443.29 PIK56820.1 - 5.4e-08 32.6 0.2 1e-07 31.8 0.2 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-B_box PF00643.24 PIK56820.1 - 0.16 12.2 5.6 6.3 7.0 1.0 2.7 2 0 0 2 2 2 0 B-box zinc finger Death PF00531.22 PIK56821.1 - 7.2e-25 87.0 19.8 2.9e-09 37.0 0.2 5.7 6 0 0 6 6 6 4 Death domain Death_2 PF14786.6 PIK56821.1 - 0.007 16.3 0.4 1 9.3 0.0 3.0 3 0 0 3 3 3 2 Tube Death domain SCAN PF02023.17 PIK56821.1 - 1.4 8.8 7.1 13 5.7 1.1 2.9 3 0 0 3 3 3 0 SCAN domain Death PF00531.22 PIK56822.1 - 6.4e-07 29.4 0.5 0.001 19.2 0.0 2.6 2 0 0 2 2 2 2 Death domain DUF5598 PF18127.1 PIK56823.1 - 0.015 15.7 0.1 0.034 14.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5598) CAP_GLY PF01302.25 PIK56823.1 - 0.016 15.3 0.1 0.042 13.9 0.1 1.8 1 0 0 1 1 1 0 CAP-Gly domain VPS13_C PF16909.5 PIK56824.1 - 4.8e-55 186.1 0.1 1e-54 185.0 0.1 1.6 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 PIK56824.1 - 1.7e-33 116.2 0.0 2.8e-32 112.2 0.0 2.5 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 Med31 PF05669.12 PIK56824.1 - 1.9e-09 37.4 0.2 1.9e-09 37.4 0.2 2.1 2 0 0 2 2 2 1 SOH1 WWE PF02825.20 PIK56824.1 - 0.11 13.0 4.0 0.15 12.7 0.0 2.6 2 0 0 2 2 2 0 WWE domain DUF3484 PF11983.8 PIK56824.1 - 0.19 12.8 0.0 0.19 12.8 0.0 2.8 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch WD40 PF00400.32 PIK56825.1 - 1.6e-08 35.1 2.3 0.00047 20.9 0.7 5.3 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56825.1 - 3.8e-08 33.5 0.0 0.0023 18.2 0.0 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TMEM154 PF15102.6 PIK56826.1 - 1.8e-05 24.7 2.5 1.8e-05 24.7 2.5 3.0 3 1 0 3 3 3 1 TMEM154 protein family DUF4448 PF14610.6 PIK56826.1 - 6.4e-05 22.8 0.1 0.00012 21.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) MLANA PF14991.6 PIK56826.1 - 6.5e-05 23.2 6.6 0.5 10.7 0.0 4.2 3 1 1 4 4 4 2 Protein melan-A Mucin PF01456.17 PIK56826.1 - 0.00089 19.3 15.2 0.00089 19.3 15.2 2.2 3 0 0 3 3 3 1 Mucin-like glycoprotein TBPIP PF07106.13 PIK56826.1 - 0.0013 18.6 2.6 9.5 6.2 0.1 3.7 3 0 0 3 3 3 1 TBPIP/Hop2 winged helix domain SRCR_2 PF15494.6 PIK56826.1 - 0.0073 16.8 2.4 65 4.2 0.0 4.7 2 1 0 4 4 4 0 Scavenger receptor cysteine-rich domain Amnionless PF14828.6 PIK56826.1 - 0.0092 14.9 0.1 0.015 14.2 0.1 1.2 1 0 0 1 1 1 1 Amnionless PhaP_Bmeg PF09602.10 PIK56826.1 - 0.044 13.7 4.3 1.3 9.0 0.3 3.5 3 0 0 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Trp_oprn_chp PF09534.10 PIK56826.1 - 0.05 13.4 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4976 PF16347.5 PIK56826.1 - 0.054 13.8 1.9 48 4.3 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4976) Rab_bind PF16704.5 PIK56826.1 - 0.087 12.9 1.0 25 5.0 0.1 3.0 2 0 0 2 2 2 0 Rab binding domain KELK PF15796.5 PIK56826.1 - 0.11 12.9 0.4 48 4.5 0.0 3.2 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase CAV_VP3 PF04771.12 PIK56826.1 - 0.13 12.4 12.3 1.3 9.1 0.5 3.7 3 0 0 3 3 3 0 Chicken anaemia virus VP-3 protein Orf78 PF06024.12 PIK56826.1 - 0.43 10.9 1.9 1.5 9.2 0.0 2.9 2 0 0 2 2 2 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 PIK56826.1 - 1.1 8.9 2.8 21 4.8 0.0 3.6 4 0 0 4 4 4 0 Baculovirus 11 kDa family RIFIN PF02009.16 PIK56826.1 - 2.9 7.7 7.0 0.27 11.1 0.1 2.4 2 1 1 3 3 3 0 Rifin RVT_1 PF00078.27 PIK56827.1 - 8.2e-37 126.9 0.0 1.2e-36 126.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CreA PF05981.12 PIK56827.1 - 0.042 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 CreA protein DUF5388 PF17363.2 PIK56827.1 - 0.11 12.7 0.2 0.3 11.3 0.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5388) TMEM154 PF15102.6 PIK56828.1 - 1.4e-05 25.0 6.0 1.6e-05 24.8 4.0 2.2 1 1 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 PIK56828.1 - 2.5e-05 24.1 0.1 4.2e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Amnionless PF14828.6 PIK56828.1 - 0.0065 15.4 0.1 0.0084 15.0 0.1 1.1 1 0 0 1 1 1 1 Amnionless Trp_oprn_chp PF09534.10 PIK56828.1 - 0.02 14.7 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MLANA PF14991.6 PIK56828.1 - 0.053 13.8 0.1 0.19 12.0 0.0 2.0 1 1 1 2 2 2 0 Protein melan-A RIFIN PF02009.16 PIK56828.1 - 0.064 13.1 0.8 0.11 12.4 0.4 1.5 1 1 0 1 1 1 0 Rifin Orf78 PF06024.12 PIK56828.1 - 0.53 10.6 2.2 0.57 10.5 0.1 2.2 2 1 0 2 2 2 0 Orf78 (ac78) Mucin PF01456.17 PIK56828.1 - 0.93 9.5 28.3 0.31 11.0 24.9 1.9 1 1 1 2 2 2 0 Mucin-like glycoprotein EVI2A PF05399.11 PIK56828.1 - 7.1 6.1 14.5 0.089 12.4 5.1 2.1 1 1 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) RVT_1 PF00078.27 PIK56829.1 - 0.0049 16.4 0.1 0.017 14.6 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK56831.1 - 2.9e-15 55.8 0.4 5.3e-15 55.0 0.4 1.4 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK56831.1 - 0.0016 18.7 1.4 0.012 15.8 0.1 2.6 2 1 1 3 3 3 1 Retrotransposon gag protein Citrate_synt PF00285.21 PIK56831.1 - 0.19 10.8 0.1 0.24 10.4 0.1 1.1 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain TMEM154 PF15102.6 PIK56832.1 - 9e-05 22.4 3.4 9e-05 22.4 3.4 2.2 2 1 1 3 3 3 1 TMEM154 protein family Mucin PF01456.17 PIK56832.1 - 0.0035 17.3 6.3 0.0035 17.3 6.3 2.5 3 0 0 3 3 3 1 Mucin-like glycoprotein DUF455 PF04305.14 PIK56833.1 - 3.4e-93 311.7 0.0 4.4e-93 311.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske_2 PF13806.6 PIK56833.1 - 6e-10 39.0 0.0 1.3e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 PIK56833.1 - 2e-09 37.3 0.0 4.5e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Tom37 PF10568.9 PIK56834.1 - 1.4e-25 90.1 0.0 2.8e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 PIK56834.1 - 4.2e-24 85.2 0.0 1.2e-23 83.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 PIK56834.1 - 5e-17 61.4 0.5 1e-16 60.4 0.5 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK56834.1 - 1.1e-05 25.4 0.1 2.4e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56834.1 - 0.011 16.0 0.2 0.02 15.1 0.2 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK56834.1 - 0.025 14.7 0.3 0.044 14.0 0.3 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TAP42 PF04177.12 PIK56835.1 - 6.8e-85 285.0 1.9 9.3e-85 284.6 1.9 1.1 1 0 0 1 1 1 1 TAP42-like family DUF3456 PF11938.8 PIK56837.1 - 4.5e-36 124.7 0.2 7.4e-36 124.0 0.2 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Sulfotransfer_1 PF00685.27 PIK56838.1 - 5.2e-07 29.4 0.1 1.2e-06 28.2 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK56838.1 - 0.0002 21.9 0.0 0.22 11.8 0.0 2.5 2 1 0 2 2 2 2 Sulfotransferase family OpcA PF07239.11 PIK56839.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein OpcA polyprenyl_synt PF00348.17 PIK56840.1 - 7.6e-39 133.3 0.0 2.7e-35 121.7 0.0 2.6 1 1 1 2 2 2 2 Polyprenyl synthetase zf-met PF12874.7 PIK56840.1 - 6.1e-07 29.6 0.9 6.1e-07 29.6 0.9 7.1 8 0 0 8 8 8 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK56840.1 - 3.8e-05 23.9 1.3 3.8e-05 23.9 1.3 6.1 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 PIK56840.1 - 0.00031 21.0 1.1 0.00031 21.0 1.1 7.9 9 0 0 9 9 9 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK56840.1 - 0.0036 17.7 2.5 0.0036 17.7 2.5 8.3 7 1 1 8 8 8 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK56840.1 - 0.0048 17.6 10.8 0.014 16.2 1.2 9.3 9 1 1 10 10 10 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK56840.1 - 0.0067 16.2 0.7 0.0067 16.2 0.7 5.9 8 0 0 8 8 8 1 C2H2-type zinc-finger domain ROS_MUCR PF05443.11 PIK56840.1 - 0.046 13.8 2.4 0.71 9.9 0.1 2.6 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-Di19 PF05605.12 PIK56840.1 - 3.8 7.9 38.8 0.45 10.8 4.7 5.6 4 1 1 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 PIK56840.1 - 6.4 6.8 18.0 19 5.3 0.5 4.8 2 1 2 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF3699 PF12480.8 PIK56841.1 - 0.017 15.3 0.5 0.042 14.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3699) GAF PF01590.26 PIK56842.1 - 6.4e-23 81.9 0.0 4.5e-18 66.2 0.0 2.5 2 0 0 2 2 2 2 GAF domain PDEase_I PF00233.19 PIK56842.1 - 5.8e-16 58.9 2.2 1.2e-07 31.7 0.4 2.5 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GAF_2 PF13185.6 PIK56842.1 - 8.3e-13 48.8 0.0 1.5e-08 35.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 PIK56842.1 - 5.8e-09 36.4 0.0 1.4e-05 25.4 0.0 2.5 2 0 0 2 2 2 2 GAF domain DUF3369 PF11849.8 PIK56842.1 - 0.00027 21.2 2.2 1.4 9.1 0.8 3.7 2 2 0 2 2 2 2 Domain of unknown function (DUF3369) SpoVT_C PF15714.5 PIK56842.1 - 0.008 16.2 0.0 7.2 6.7 0.0 2.6 2 0 0 2 2 2 2 Stage V sporulation protein T C-terminal, transcription factor S_tail_recep_bd PF14928.6 PIK56843.1 - 0.02 15.5 0.0 0.037 14.7 0.0 1.4 1 0 0 1 1 1 0 Short tail fibre protein receptor-binding domain RseC_MucC PF04246.12 PIK56843.1 - 0.38 10.7 0.1 0.38 10.7 0.1 2.5 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Zip PF02535.22 PIK56844.1 - 2.3e-70 237.5 10.7 2.3e-70 237.5 10.7 1.6 2 0 0 2 2 2 1 ZIP Zinc transporter CCDC24 PF15669.5 PIK56844.1 - 0.19 11.6 0.1 0.33 10.8 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family HOOK PF05622.12 PIK56845.1 - 0.0061 14.8 21.1 0.0071 14.6 21.1 1.0 1 0 0 1 1 1 1 HOOK protein EMC3_TMCO1 PF01956.16 PIK56845.1 - 0.0075 16.0 1.6 0.015 15.1 1.5 1.5 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like MetOD2 PF18548.1 PIK56845.1 - 0.032 14.3 1.8 0.032 14.3 1.8 2.3 2 1 0 2 2 2 0 Metanogen output domain 2 BLOC1_2 PF10046.9 PIK56845.1 - 0.062 13.6 12.6 0.14 12.5 2.3 3.3 2 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.18 PIK56845.1 - 0.18 12.1 9.4 0.73 10.2 0.9 2.9 2 1 1 3 3 3 0 TSC-22/dip/bun family GAS PF13851.6 PIK56845.1 - 0.21 10.9 23.7 0.068 12.5 9.7 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 PIK56845.1 - 0.22 11.7 18.6 0.37 10.9 18.6 1.4 1 0 0 1 1 1 0 Tropomyosin like MCC-bdg_PDZ PF10506.9 PIK56845.1 - 0.23 11.5 9.1 0.048 13.7 2.1 2.7 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Atg14 PF10186.9 PIK56845.1 - 0.27 10.3 17.8 0.43 9.6 17.8 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 PIK56845.1 - 0.31 11.1 22.8 3.9 7.5 22.8 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-H PF05837.12 PIK56845.1 - 0.33 11.4 19.4 0.23 11.9 9.7 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ERM PF00769.19 PIK56845.1 - 0.51 10.1 20.1 0.67 9.7 20.1 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF501 PF04417.12 PIK56845.1 - 0.9 9.3 5.6 0.46 10.3 2.7 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF501) DUF4200 PF13863.6 PIK56845.1 - 1.1 9.7 18.6 0.046 14.1 7.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) YabA PF06156.13 PIK56845.1 - 1.1 9.9 14.8 0.89 10.2 5.4 2.3 1 1 1 2 2 2 0 Initiation control protein YabA CREPT PF16566.5 PIK56845.1 - 1.2 9.3 21.1 2.1 8.5 6.6 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Jnk-SapK_ap_N PF09744.9 PIK56845.1 - 1.5 9.0 24.1 0.25 11.6 12.0 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliD_C PF07195.12 PIK56845.1 - 1.6 8.1 16.3 2 7.8 6.1 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Exonuc_VII_L PF02601.15 PIK56845.1 - 2.1 7.8 14.9 2.9 7.4 14.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Viral_P18 PF04521.13 PIK56845.1 - 2.3 8.0 7.0 1.1 9.1 0.9 2.1 1 1 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Mto2_bdg PF12808.7 PIK56845.1 - 3.7 7.9 7.7 7 7.0 0.2 2.6 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Vir_act_alpha_C PF10400.9 PIK56845.1 - 4.1 8.2 12.5 8.9 7.1 1.0 3.5 1 1 1 2 2 2 0 Virulence activator alpha C-term ZapB PF06005.12 PIK56845.1 - 6.3 7.3 20.4 0.59 10.6 7.6 2.7 1 1 1 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 PIK56845.1 - 8.9 6.4 17.8 1.7 8.7 6.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cnn_1N PF07989.11 PIK56845.1 - 9.1 6.5 18.5 0.22 11.7 4.3 3.5 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DHR10 PF18595.1 PIK56845.1 - 9.2 6.4 25.5 0.14 12.2 11.1 2.6 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain GRAS PF03514.14 PIK56846.1 - 0.01 14.8 0.8 0.015 14.2 0.8 1.2 1 0 0 1 1 1 0 GRAS domain family DUF1943 PF09172.11 PIK56846.1 - 0.012 14.9 3.0 0.019 14.2 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) SHE3 PF17078.5 PIK56846.1 - 0.021 14.6 10.3 0.03 14.0 10.3 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Omp_AT PF11557.8 PIK56846.1 - 0.028 13.4 0.2 0.029 13.3 0.2 1.3 1 0 0 1 1 1 0 Solitary outer membrane autotransporter beta-barrel domain SPOB_ab PF14682.6 PIK56846.1 - 0.11 12.6 1.8 0.64 10.1 0.6 2.3 1 1 1 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal MCC-bdg_PDZ PF10506.9 PIK56846.1 - 0.12 12.4 4.3 0.3 11.1 1.1 2.8 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF2532 PF10811.8 PIK56846.1 - 1.1 9.3 7.8 7.1 6.7 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2532) CENP-F_leu_zip PF10473.9 PIK56846.1 - 2.3 8.2 19.0 0.14 12.2 11.8 2.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2968 PF11180.8 PIK56846.1 - 4.6 6.8 13.4 0.54 9.9 1.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2968) DUF4140 PF13600.6 PIK56846.1 - 7.5 7.1 7.1 9.5 6.7 0.4 3.1 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) ING PF12998.7 PIK56847.1 - 0.00048 20.7 1.1 0.00048 20.7 1.1 2.8 2 1 1 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding Tropomyosin_1 PF12718.7 PIK56847.1 - 0.014 15.6 15.2 0.014 15.6 15.2 3.4 2 1 1 3 3 3 0 Tropomyosin like PilO PF04350.13 PIK56847.1 - 0.051 13.7 0.6 0.051 13.7 0.6 3.7 4 0 0 4 4 4 0 Pilus assembly protein, PilO FUSC PF04632.12 PIK56847.1 - 9.4 4.6 8.9 12 4.3 0.3 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family Pkinase_Tyr PF07714.17 PIK56848.1 - 2e-32 112.5 0.0 4e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK56848.1 - 1.3e-29 103.4 0.0 1.9e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 PIK56848.1 - 0.0022 16.9 0.0 0.0046 15.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase DUF624 PF04854.14 PIK56848.1 - 0.036 14.2 0.0 0.086 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF624 PX PF00787.24 PIK56849.1 - 1e-20 73.8 0.3 3.4e-20 72.1 0.3 1.9 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 PIK56849.1 - 0.00034 20.2 10.5 0.033 13.7 1.0 2.3 1 1 1 2 2 2 2 Vps5 C terminal like GrpE PF01025.19 PIK56849.1 - 0.17 11.5 4.8 0.056 13.1 1.2 1.9 2 0 0 2 2 2 0 GrpE Collagen PF01391.18 PIK56850.1 - 0.19 11.5 4.2 0.31 10.8 4.2 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) zf-C2H2 PF00096.26 PIK56853.1 - 9.7e-21 73.0 24.8 7.9e-05 22.9 0.5 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK56853.1 - 8e-14 51.3 26.0 1.6e-06 28.2 0.5 5.3 5 0 0 5 5 5 3 Zinc-finger double domain FOXP-CC PF16159.5 PIK56853.1 - 1.8e-11 44.5 15.3 0.0012 19.4 0.0 5.2 1 1 2 4 4 4 3 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 PIK56853.1 - 1.1e-05 25.8 37.2 0.0012 19.5 0.3 6.1 6 0 0 6 6 6 4 C2H2-type zinc finger zf_ZIC PF18366.1 PIK56853.1 - 0.00061 19.8 7.7 0.025 14.7 0.2 4.2 1 1 2 3 3 3 1 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 PIK56853.1 - 0.0013 18.9 14.5 0.31 11.1 2.3 3.5 2 1 1 3 3 3 3 Aberrant zinc-finger PcF PF09461.10 PIK56853.1 - 0.029 14.7 5.1 15 6.1 0.1 3.6 2 1 1 3 3 3 0 Phytotoxin PcF protein zf-C2H2_8 PF15909.5 PIK56853.1 - 0.16 12.3 11.9 0.56 10.5 0.7 4.0 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 PIK56853.1 - 0.59 9.9 0.0 0.59 9.9 0.0 3.9 4 0 0 4 4 4 0 C2H2-type zinc-finger domain DUF629 PF04780.12 PIK56853.1 - 2.7 6.4 11.1 3.3 6.1 1.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF629) Fasciclin PF02469.22 PIK56854.1 - 5.6e-42 143.0 0.2 2.6e-20 72.9 0.1 2.3 2 0 0 2 2 2 2 Fasciclin domain Sulfotransfer_2 PF03567.14 PIK56855.1 - 2.5e-11 44.0 0.2 2.5e-11 44.0 0.2 1.7 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK56856.1 - 4e-11 43.3 0.2 8.5e-11 42.2 0.0 1.6 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK56856.1 - 0.039 13.4 0.1 0.44 10.0 0.1 2.3 1 1 0 1 1 1 0 Sulfotransferase domain KTI12 PF08433.10 PIK56857.1 - 4.3e-78 262.5 0.0 4.7e-78 262.4 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 PIK56857.1 - 1.3e-07 31.8 0.0 1.5e-06 28.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 PIK56857.1 - 0.0095 15.5 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 PIK56857.1 - 0.015 15.5 0.0 4.8 7.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 PIK56857.1 - 0.037 14.6 0.2 0.058 13.9 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK56857.1 - 0.057 13.8 0.0 0.11 12.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 PIK56857.1 - 0.15 12.4 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Hemopexin PF00045.19 PIK56858.1 - 1.6e-30 104.8 2.9 3.9e-12 45.9 0.1 4.3 4 0 0 4 4 4 4 Hemopexin Hemopexin PF00045.19 PIK56859.1 - 2e-34 117.3 6.1 4.4e-12 45.8 0.6 4.4 4 0 0 4 4 4 4 Hemopexin LXG PF04740.12 PIK56860.1 - 0.0085 15.8 2.3 0.013 15.2 0.4 1.8 1 1 1 2 2 2 2 LXG domain of WXG superfamily Sec20 PF03908.13 PIK56860.1 - 0.014 15.3 0.8 0.014 15.3 0.8 1.8 2 0 0 2 2 2 0 Sec20 SLATT_6 PF18169.1 PIK56860.1 - 0.033 13.8 0.8 0.045 13.4 0.8 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF334 PF03904.13 PIK56860.1 - 0.057 13.0 5.4 0.077 12.5 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) ALMT PF11744.8 PIK56860.1 - 0.087 11.6 1.7 0.11 11.3 1.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec34 PF04136.15 PIK56860.1 - 0.67 9.8 5.7 0.18 11.7 1.1 1.8 2 1 1 3 3 3 0 Sec34-like family Cauli_AT PF03233.13 PIK56860.1 - 0.72 9.8 3.9 1.1 9.1 3.9 1.2 1 0 0 1 1 1 0 Aphid transmission protein TMPIT PF07851.13 PIK56860.1 - 1 8.5 3.4 1.5 8.0 3.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein Peptidase_A17 PF05380.13 PIK56861.1 - 2e-36 125.5 0.2 3.1e-36 124.8 0.2 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK56861.1 - 7.8e-06 25.6 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK56861.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK56861.1 - 0.06 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase BBIP10 PF14777.6 PIK56861.1 - 0.12 12.0 0.1 0.27 10.8 0.1 1.5 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RVT_3 PF13456.6 PIK56861.1 - 0.12 12.1 0.0 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase-like DUF5641 PF18701.1 PIK56862.1 - 9.7e-34 115.4 6.2 2e-33 114.4 6.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Ferrochelatase PF00762.19 PIK56862.1 - 3e-16 59.4 0.1 4.7e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 Ferrochelatase rve PF00665.26 PIK56862.1 - 1.2e-05 25.5 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain tRNA_anti-codon PF01336.25 PIK56862.1 - 0.12 12.4 0.1 0.41 10.7 0.1 1.9 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain zf-DNL PF05180.12 PIK56863.1 - 2.2e-29 101.2 0.1 3.4e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.13 PIK56863.1 - 0.025 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like LSM PF01423.22 PIK56864.1 - 1.8e-16 59.6 0.0 2.5e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 PIK56864.1 - 0.0044 17.1 0.1 0.0066 16.6 0.1 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain PY_rept_46 PF09689.10 PIK56865.1 - 9.4e-11 42.1 42.0 0.81 10.3 0.5 10.4 1 1 13 14 14 14 10 Plasmodium yoelii repeat (PY_rept_46) FlhC PF05280.11 PIK56865.1 - 9.4e-07 28.7 16.7 0.068 12.9 0.8 4.3 1 1 4 5 5 5 5 Flagellar transcriptional activator (FlhC) DUF3106 PF11304.8 PIK56865.1 - 1.3e-06 28.8 24.1 0.0052 17.2 2.3 4.4 1 1 3 4 4 4 3 Protein of unknown function (DUF3106) Spore_YhaL PF14147.6 PIK56865.1 - 0.034 13.8 25.1 47 3.8 0.1 9.6 6 3 4 10 10 10 0 Sporulation protein YhaL COX16 PF14138.6 PIK56865.1 - 0.38 11.3 23.0 17 6.0 0.3 5.8 1 1 4 5 5 5 0 Cytochrome c oxidase assembly protein COX16 DUF4883 PF16224.5 PIK56865.1 - 0.52 10.6 18.2 7 6.9 0.4 4.7 1 1 4 5 5 5 0 DOmain of unknown function (DUF4883) Zip PF02535.22 PIK56866.1 - 2.3e-75 253.9 9.9 2.3e-75 253.9 9.9 2.4 1 1 1 2 2 2 1 ZIP Zinc transporter CRA PF06589.11 PIK56866.1 - 0.00055 20.0 1.7 0.52 10.4 0.7 2.5 2 0 0 2 2 2 2 Circumsporozoite-related antigen (CRA) SARAF PF06682.12 PIK56866.1 - 0.061 13.0 0.3 0.24 11.0 0.1 1.8 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Otopetrin PF03189.13 PIK56866.1 - 0.14 11.0 0.0 0.63 8.8 0.0 2.0 1 1 0 1 1 1 0 Otopetrin DUF2514 PF10721.9 PIK56866.1 - 0.14 12.1 0.1 1 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DUF1772 PF08592.11 PIK56866.1 - 0.16 12.2 0.0 17 5.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF4834 PF16118.5 PIK56866.1 - 0.3 12.1 4.3 2.3 9.2 0.9 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 PIK56866.1 - 9.6 5.9 9.5 3.9 7.1 0.1 3.1 3 1 1 4 4 4 0 FAM176 family Zona_pellucida PF00100.23 PIK56867.1 - 0.00014 21.8 0.3 0.00034 20.5 0.0 1.8 2 0 0 2 2 2 1 Zona pellucida-like domain Zona_pellucida PF00100.23 PIK56868.1 - 1e-16 61.6 0.0 1.2e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain AI-2E_transport PF01594.16 PIK56869.1 - 0.0013 18.0 0.1 0.0014 17.8 0.1 1.1 1 0 0 1 1 1 1 AI-2E family transporter SUR7 PF06687.12 PIK56869.1 - 0.035 13.7 0.0 0.035 13.7 0.0 1.1 1 0 0 1 1 1 0 SUR7/PalI family Pkinase PF00069.25 PIK56870.1 - 6.8e-47 160.0 0.2 1.7e-26 93.2 0.1 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56870.1 - 6.1e-18 65.0 0.1 1.1e-15 57.7 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 PIK56870.1 - 0.00026 21.0 0.0 0.14 12.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK56870.1 - 0.0033 16.8 0.1 0.0062 15.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK56870.1 - 0.012 14.4 0.2 0.036 12.8 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase DEAD PF00270.29 PIK56871.1 - 1.6e-51 174.5 0.0 3e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK56871.1 - 3.3e-28 98.2 0.0 7.5e-27 93.9 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CdAMP_rec PF06153.11 PIK56871.1 - 0.06 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Cyclic-di-AMP receptor RRN3 PF05327.11 PIK56871.1 - 3.4 6.1 15.5 5.3 5.5 15.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SIR4_SID PF16991.5 PIK56872.1 - 0.19 11.8 2.4 0.13 12.3 0.6 1.6 2 0 0 2 2 2 0 Sir4 SID domain RasGAP PF00616.19 PIK56873.1 - 2.2e-22 79.8 0.1 4.4e-22 78.8 0.1 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CDI PF02234.19 PIK56873.1 - 0.016 15.4 0.0 1.3 9.3 0.0 2.6 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor VPS9 PF02204.18 PIK56875.1 - 7.8e-25 87.1 0.0 2.4e-24 85.5 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 PIK56875.1 - 3.5e-06 27.2 0.2 1.1e-05 25.6 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) Pox_C4_C10 PF03336.13 PIK56875.1 - 0.019 14.1 0.3 0.034 13.2 0.3 1.3 1 0 0 1 1 1 0 Poxvirus C4/C10 protein TGT PF01702.18 PIK56876.1 - 6.5e-78 262.3 0.0 8e-78 262.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Ig_3 PF13927.6 PIK56877.1 - 1.2e-91 301.4 2.3 1.5e-14 54.3 0.0 9.2 9 0 0 9 9 9 8 Immunoglobulin domain I-set PF07679.16 PIK56877.1 - 6.7e-91 298.5 0.0 1.6e-14 53.7 0.0 8.8 9 0 0 9 9 8 8 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK56877.1 - 1.4e-67 224.0 0.2 5.6e-10 39.4 0.0 8.6 7 1 1 8 8 8 7 Immunoglobulin domain ig PF00047.25 PIK56877.1 - 3.6e-53 177.7 1.9 3.6e-09 36.7 0.0 8.9 9 0 0 9 9 9 6 Immunoglobulin domain fn3 PF00041.21 PIK56877.1 - 5.9e-47 157.9 10.1 2.9e-10 40.4 0.0 6.0 5 0 0 5 5 5 5 Fibronectin type III domain V-set PF07686.17 PIK56877.1 - 2e-25 89.1 20.3 0.0016 18.6 0.2 13.3 9 5 0 10 10 10 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK56877.1 - 1e-19 70.3 2.0 0.00072 19.6 0.0 7.8 7 0 0 7 7 7 4 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK56877.1 - 8.1e-12 44.5 0.0 0.17 11.4 0.0 6.6 7 0 0 7 7 7 3 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK56877.1 - 2e-06 27.7 0.0 0.035 14.1 0.0 4.9 5 1 0 5 5 5 1 C17orf99 Ig domain fn3_2 PF16893.5 PIK56877.1 - 1.1e-05 25.5 0.7 1 9.6 0.1 4.5 4 1 0 4 4 4 1 Fibronectin type III domain C1-set PF07654.15 PIK56877.1 - 1.1e-05 25.6 0.1 21 5.6 0.0 6.1 6 0 0 6 6 6 0 Immunoglobulin C1-set domain Pur_ac_phosph_N PF16656.5 PIK56877.1 - 1.5e-05 25.5 10.4 0.08 13.5 0.0 5.6 4 2 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 PIK56877.1 - 6.3e-05 22.8 0.3 0.049 13.5 0.2 3.3 3 0 0 3 3 3 1 Tissue factor Izumo-Ig PF16706.5 PIK56877.1 - 0.0096 16.0 0.1 3.1 7.9 0.0 4.8 7 0 0 7 7 6 1 Izumo-like Immunoglobulin domain DUF2207 PF09972.9 PIK56877.1 - 3.1 6.4 9.0 2.2 7.0 3.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) GH3 PF03321.13 PIK56878.1 - 6.9e-35 120.9 2.8 1.7e-18 66.8 0.2 2.1 2 0 0 2 2 2 2 GH3 auxin-responsive promoter Tropomyosin_1 PF12718.7 PIK56879.1 - 0.018 15.2 2.3 0.018 15.2 2.3 1.5 2 0 0 2 2 1 0 Tropomyosin like Fib_alpha PF08702.10 PIK56879.1 - 0.039 14.1 7.9 0.087 13.0 7.9 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family ATG16 PF08614.11 PIK56879.1 - 0.045 14.0 4.5 0.074 13.3 4.5 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF641 PF04859.12 PIK56879.1 - 0.048 14.0 5.8 0.09 13.1 5.8 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) ToxN_toxin PF13958.6 PIK56879.1 - 0.064 13.5 3.4 0.099 12.9 3.4 1.2 1 0 0 1 1 1 0 Toxin ToxN, type III toxin-antitoxin system YabA PF06156.13 PIK56879.1 - 0.083 13.5 2.4 0.1 13.3 0.6 1.9 2 0 0 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 PIK56879.1 - 0.1 11.9 7.2 0.1 11.8 6.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) LPD15 PF18828.1 PIK56879.1 - 0.11 12.3 0.5 0.7 9.8 0.1 2.1 1 1 1 2 2 2 0 Large polyvalent-protein-associated domain 15 Syntaxin-6_N PF09177.11 PIK56879.1 - 0.14 12.7 3.6 0.3 11.7 3.6 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TMF_TATA_bd PF12325.8 PIK56879.1 - 0.15 12.2 9.6 4.1 7.7 2.2 2.5 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 PIK56879.1 - 0.27 11.3 8.4 0.4 10.8 8.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HIP1_clath_bdg PF16515.5 PIK56879.1 - 0.35 11.5 8.3 0.29 11.8 6.6 1.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SlyX PF04102.12 PIK56879.1 - 1.7 9.3 6.8 2.8 8.6 5.7 1.9 1 1 1 2 2 2 0 SlyX DUF4094 PF13334.6 PIK56879.1 - 1.9 9.0 4.8 34 4.9 4.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) TMF_DNA_bd PF12329.8 PIK56879.1 - 2.7 8.1 9.7 0.67 10.0 6.1 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DHR10 PF18595.1 PIK56879.1 - 6.2 6.9 13.2 4 7.5 8.5 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 PIK56879.1 - 7.4 7.1 9.9 15 6.1 9.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region RVT_1 PF00078.27 PIK56880.1 - 2e-35 122.3 0.0 2.7e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) N6_N4_Mtase PF01555.18 PIK56881.1 - 0.024 14.4 0.1 0.043 13.5 0.1 1.3 1 1 0 1 1 1 0 DNA methylase Peptidase_M55 PF04951.13 PIK56881.1 - 0.14 11.6 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 D-aminopeptidase BEN PF10523.9 PIK56883.1 - 1.3e-06 28.5 0.1 4.8e-06 26.7 0.1 2.0 1 1 0 1 1 1 1 BEN domain MIP-T3 PF10243.9 PIK56883.1 - 0.11 12.5 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CH-like domain Transposase_21 PF02992.14 PIK56884.1 - 4.5e-09 35.9 0.0 7.9e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Transposase family tnp2 DUF4218 PF13960.6 PIK56884.1 - 0.00026 20.6 0.1 0.0047 16.5 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) DDE_Tnp_4 PF13359.6 PIK56885.1 - 3.9e-36 124.1 0.0 5.6e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK56885.1 - 1.7e-06 27.8 0.5 1.5e-05 24.7 0.5 1.9 1 1 0 1 1 1 1 Plant transposon protein Cut8 PF08559.10 PIK56887.1 - 0.03 14.0 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein zf-CCHC_2 PF13696.6 PIK56889.1 - 0.00019 21.2 6.3 0.0057 16.4 0.2 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 PIK56889.1 - 0.00027 20.9 15.4 0.0064 16.5 3.3 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK56889.1 - 0.0008 19.1 14.2 0.56 10.0 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK56889.1 - 4.8 7.5 11.8 1.5 9.1 6.6 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain LOH1CR12 PF10158.9 PIK56890.1 - 0.063 13.3 2.9 0.11 12.5 2.9 1.4 1 0 0 1 1 1 0 Tumour suppressor protein Asp_protease_2 PF13650.6 PIK56894.1 - 0.0026 18.4 0.0 0.0072 16.9 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK56894.1 - 0.0031 18.0 0.0 0.01 16.4 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 PIK56894.1 - 0.011 16.0 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease ANF_receptor PF01094.28 PIK56895.1 - 8.2e-18 64.6 0.0 1.3e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region CENP-B_dimeris PF09026.10 PIK56895.1 - 0.0012 19.2 13.0 0.0021 18.4 13.0 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain RXT2_N PF08595.11 PIK56895.1 - 0.018 15.1 4.3 0.032 14.3 4.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.6 PIK56895.1 - 0.024 15.0 10.6 0.044 14.2 10.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 PIK56895.1 - 0.27 9.3 13.1 0.38 8.8 13.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi GCIP PF13324.6 PIK56895.1 - 1.7 8.2 7.7 2.5 7.6 7.7 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 PIK56895.1 - 1.8 7.0 8.0 2.5 6.5 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 PIK56895.1 - 2.1 7.6 20.0 3.5 6.9 20.0 1.3 1 0 0 1 1 1 0 NOA36 protein Pox_RNA_Pol_19 PF05320.12 PIK56895.1 - 3.4 7.6 8.5 0.61 10.1 4.1 1.8 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Utp14 PF04615.13 PIK56895.1 - 4.5 5.7 8.2 5.8 5.4 8.2 1.0 1 0 0 1 1 1 0 Utp14 protein DUF2457 PF10446.9 PIK56895.1 - 7.4 5.6 23.5 10 5.2 23.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4611 PF15387.6 PIK56895.1 - 8.4 6.7 11.0 17 5.7 11.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Guanylate_cyc PF00211.20 PIK56896.1 - 3e-68 229.0 0.1 4.2e-68 228.6 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK56896.1 - 0.00026 20.5 0.4 0.0004 19.9 0.4 1.3 1 0 0 1 1 1 1 Heme NO binding associated IQ PF00612.27 PIK56897.1 - 2e-14 52.0 23.6 4e-05 23.0 1.8 5.6 6 0 0 6 6 6 3 IQ calmodulin-binding motif TFIIE-A_C PF11521.8 PIK56897.1 - 0.38 11.1 2.3 0.59 10.5 0.3 2.2 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Dfp1_Him1_M PF08630.10 PIK56897.1 - 2.8 8.2 10.3 3 8.1 0.1 3.4 3 0 0 3 3 3 0 Dfp1/Him1, central region CLASP_N PF12348.8 PIK56898.1 - 2.8e-37 128.5 6.7 1.7e-34 119.4 0.9 2.3 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 PIK56898.1 - 0.0016 18.6 0.6 4.5 7.8 0.1 4.8 6 0 0 6 6 6 1 HEAT repeat Anti-adapt_IraP PF10796.9 PIK56898.1 - 0.068 13.7 0.0 0.21 12.2 0.0 1.9 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein MMS19_N PF14500.6 PIK56898.1 - 0.2 11.2 1.8 1.5 8.4 0.0 2.9 3 1 1 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II Ada3 PF10198.9 PIK56899.1 - 0.064 13.4 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 HEAT_2 PF13646.6 PIK56900.1 - 2.5e-08 34.2 0.1 0.00045 20.5 0.0 2.9 1 1 2 3 3 3 3 HEAT repeats Cnd1 PF12717.7 PIK56900.1 - 1.4e-07 31.7 1.4 0.00042 20.4 0.3 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK56900.1 - 1.2e-06 28.9 0.0 0.0017 18.8 0.0 3.2 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 PIK56900.1 - 1.6e-06 27.9 0.7 0.0024 18.0 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat RTP1_C1 PF10363.9 PIK56900.1 - 7.8e-05 22.8 0.6 0.47 10.6 0.1 2.4 2 0 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 PIK56900.1 - 0.00013 20.7 1.6 0.14 10.7 0.4 2.2 1 1 1 2 2 2 2 Adaptin N terminal region MMS19_C PF12460.8 PIK56900.1 - 0.0013 18.0 0.6 0.29 10.2 0.0 2.2 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 PIK56900.1 - 0.0015 18.2 0.1 0.0023 17.6 0.1 1.3 1 0 0 1 1 1 1 CLASP N terminal DUF4042 PF13251.6 PIK56900.1 - 0.0015 18.3 0.6 0.012 15.4 0.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4042) V-ATPase_H_N PF03224.14 PIK56900.1 - 0.0018 17.6 0.0 0.32 10.2 0.0 2.1 1 1 1 2 2 2 2 V-ATPase subunit H Tti2 PF10521.9 PIK56900.1 - 0.0021 17.7 0.1 1.6 8.2 0.0 2.2 2 0 0 2 2 2 2 Tti2 family Ipi1_N PF12333.8 PIK56900.1 - 0.021 15.4 0.0 0.15 12.7 0.0 2.4 1 1 1 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.7 PIK56900.1 - 0.073 13.7 0.1 5.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region RasGEF_N_2 PF14663.6 PIK56900.1 - 0.15 12.5 0.3 0.75 10.2 0.1 2.2 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SIL1 PF16782.5 PIK56900.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 Dymeclin PF09742.9 PIK56901.1 - 2e-122 409.8 8.2 2.3e-122 409.5 8.2 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 PIK56901.1 - 1.6e-08 33.2 12.4 1.4e-05 23.4 9.0 2.2 2 0 0 2 2 2 2 High-temperature-induced dauer-formation protein KH_1 PF00013.29 PIK56902.1 - 1.2e-30 105.1 2.2 1.3e-15 56.9 0.5 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 PIK56902.1 - 1e-10 41.3 5.3 6.2e-07 29.2 1.6 2.2 1 1 1 2 2 2 2 KH domain KH_4 PF13083.6 PIK56902.1 - 2.4e-06 27.3 1.3 0.021 14.7 0.1 2.6 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 PIK56902.1 - 0.00023 21.2 2.2 0.079 13.1 0.4 2.7 2 0 0 2 2 2 2 NusA-like KH domain KH_1 PF00013.29 PIK56903.1 - 7.8e-12 44.8 0.0 1.1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 PIK56903.1 - 0.14 12.0 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 KH domain Collagen PF01391.18 PIK56904.1 - 0.01 15.6 6.1 0.015 15.0 6.1 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Metallophos PF00149.28 PIK56905.1 - 1.1e-34 120.8 0.3 2.4e-34 119.6 0.3 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 PIK56905.1 - 8.6e-29 99.7 0.5 2.4e-28 98.3 0.5 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 PIK56905.1 - 2.4e-06 27.1 2.4 2.9e-05 23.7 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56905.1 - 0.00068 19.6 2.8 0.0014 18.6 0.2 2.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK56905.1 - 0.1 13.3 1.4 0.39 11.4 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat bPH_4 PF06713.11 PIK56905.1 - 0.11 12.5 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial PH domain TPR_8 PF13181.6 PIK56905.1 - 0.28 11.5 1.9 0.58 10.5 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NTPase_1 PF03266.15 PIK56906.1 - 5.5e-51 172.8 0.2 6.1e-51 172.7 0.2 1.0 1 0 0 1 1 1 1 NTPase AAA PF00004.29 PIK56906.1 - 0.0015 19.0 0.0 0.0039 17.6 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK56906.1 - 0.016 15.2 0.0 3.7 7.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 PIK56906.1 - 0.033 13.9 0.2 0.15 11.8 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK56906.1 - 0.067 13.5 0.0 0.27 11.5 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 PIK56906.1 - 0.086 13.3 0.1 0.15 12.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK56906.1 - 0.1 13.0 0.2 1.8 8.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 PIK56906.1 - 0.13 12.0 0.1 1.7 8.3 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 PIK56906.1 - 0.17 11.1 0.1 0.35 10.0 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain LRR_8 PF13855.6 PIK56907.1 - 1.2e-22 79.4 16.3 2.6e-06 27.1 0.8 4.2 2 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK56907.1 - 1.6e-17 63.3 18.4 0.00035 20.9 0.9 4.4 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK56907.1 - 1.2e-06 28.2 6.5 0.0019 17.7 1.8 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK56907.1 - 6.9e-06 25.9 19.5 0.23 12.1 0.4 6.8 6 2 1 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK56907.1 - 0.00012 21.8 18.1 0.13 12.3 0.2 6.4 7 0 0 7 7 7 2 Leucine Rich repeat LRR_5 PF13306.6 PIK56907.1 - 0.034 14.1 0.4 0.082 12.9 0.4 1.6 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) RsmF_methylt_CI PF17126.5 PIK56907.1 - 0.056 13.5 0.0 8.5 6.5 0.0 3.4 3 1 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain p450 PF00067.22 PIK56908.1 - 5e-84 282.7 0.3 5.5e-84 282.5 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_2 PF07719.17 PIK56909.1 - 2.1e-32 108.6 8.7 0.0041 17.1 0.1 8.7 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56909.1 - 1.5e-29 100.5 6.6 3.9e-06 26.5 0.1 7.7 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56909.1 - 1.9e-24 83.8 1.0 0.0018 18.3 0.0 7.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56909.1 - 9.2e-19 67.5 12.8 6.5e-07 29.6 0.1 6.3 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 PIK56909.1 - 2.9e-17 63.0 2.3 0.00086 19.9 0.4 6.2 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56909.1 - 1.5e-16 59.7 4.3 0.0097 16.7 0.0 7.6 1 1 7 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56909.1 - 3.8e-13 49.7 5.7 0.0018 18.7 0.0 5.2 3 2 2 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56909.1 - 3.5e-10 39.2 10.1 0.0023 17.8 0.0 6.9 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK56909.1 - 9.5e-09 35.1 9.9 0.0015 18.8 0.1 7.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK56909.1 - 5.2e-08 33.0 10.5 0.63 10.8 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56909.1 - 6.7e-07 29.0 8.3 0.13 12.1 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK56909.1 - 8.8e-07 29.0 3.4 1.1 9.5 0.0 5.6 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 PIK56909.1 - 1.6e-06 27.6 4.3 0.00016 21.0 0.8 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK56909.1 - 4.6e-06 26.2 5.5 0.67 9.7 0.0 5.8 5 3 1 6 6 6 2 TPR repeat Coatomer_E PF04733.14 PIK56909.1 - 0.00024 20.6 2.0 0.061 12.7 0.1 2.9 2 1 2 4 4 4 2 Coatomer epsilon subunit DUF5112 PF17139.4 PIK56909.1 - 0.0012 18.5 0.9 0.33 10.4 0.1 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF5112) RPN7 PF10602.9 PIK56909.1 - 0.17 11.6 2.7 7 6.3 0.1 3.7 2 2 1 4 4 4 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 PIK56909.1 - 0.32 11.2 15.9 0.8 10.0 0.1 4.0 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 SH3_1 PF00018.28 PIK56910.1 - 2.2e-11 43.2 0.1 6e-11 41.8 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK56910.1 - 2.5e-09 36.8 0.1 7.7e-09 35.3 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK56910.1 - 4.5e-09 35.9 0.0 9.1e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TIP120 PF08623.10 PIK56910.1 - 0.0093 15.8 3.0 0.034 13.9 1.9 2.1 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) SH3_10 PF17902.1 PIK56910.1 - 0.0096 16.0 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain NPV_P10 PF05531.12 PIK56910.1 - 0.084 13.3 1.2 0.3 11.6 1.2 2.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Allexi_40kDa PF05549.11 PIK56910.1 - 0.25 10.8 1.5 0.45 10.0 1.5 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein FliD_N PF02465.18 PIK56910.1 - 3.1 8.5 5.9 42 4.9 5.9 2.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TFR_dimer PF04253.15 PIK56911.1 - 6.4e-28 97.3 0.0 1.1e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 PIK56911.1 - 4.6e-17 62.3 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 PIK56911.1 - 1.2e-10 41.3 0.0 9.7e-10 38.3 0.0 2.2 2 0 0 2 2 2 1 PA domain DHR10 PF18595.1 PIK56912.1 - 0.00023 21.2 17.4 0.00023 21.2 17.4 2.0 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain GAS PF13851.6 PIK56912.1 - 0.00024 20.5 15.4 0.00024 20.5 15.4 1.9 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Uso1_p115_C PF04871.13 PIK56912.1 - 0.0027 18.1 21.0 0.0027 18.1 21.0 1.9 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region Cauli_AT PF03233.13 PIK56912.1 - 0.0029 17.6 6.7 0.0029 17.6 6.7 1.9 1 1 1 2 2 2 1 Aphid transmission protein EzrA PF06160.12 PIK56912.1 - 0.0044 15.3 15.4 0.0044 15.3 14.6 1.4 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 PIK56912.1 - 0.0068 16.8 7.7 0.21 12.0 6.3 2.6 1 1 1 2 2 2 1 Flagella accessory protein C (FlaC) Spore_III_AB PF09548.10 PIK56912.1 - 0.012 15.8 8.7 0.012 15.8 8.7 2.2 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF3584 PF12128.8 PIK56912.1 - 0.021 12.4 16.9 0.025 12.1 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) KELK PF15796.5 PIK56912.1 - 0.022 15.2 12.9 0.022 15.2 12.9 3.1 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HALZ PF02183.18 PIK56912.1 - 0.032 14.5 13.6 0.18 12.0 1.2 3.6 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF4062 PF13271.6 PIK56912.1 - 0.077 13.4 0.7 0.22 11.9 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4062) CENP-H PF05837.12 PIK56912.1 - 0.28 11.6 19.8 0.032 14.6 14.1 2.1 2 1 0 2 2 2 0 Centromere protein H (CENP-H) FlpD PF02662.16 PIK56912.1 - 0.33 11.0 2.0 0.86 9.6 0.1 2.0 1 1 1 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit PPL5 PF18168.1 PIK56912.1 - 0.37 10.0 6.5 0.56 9.4 6.5 1.2 1 0 0 1 1 1 0 Prim-pol family 5 CCDC-167 PF15188.6 PIK56912.1 - 0.47 10.8 22.8 0.24 11.8 2.1 3.4 1 1 3 4 4 4 0 Coiled-coil domain-containing protein 167 Ocular_alb PF02101.15 PIK56912.1 - 0.7 8.7 2.1 0.84 8.5 2.1 1.1 1 0 0 1 1 1 0 Ocular albinism type 1 protein DUF1479 PF07350.12 PIK56912.1 - 0.96 8.1 5.8 1.1 8.0 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) Taxilin PF09728.9 PIK56912.1 - 0.99 8.5 25.9 0.065 12.4 19.0 1.8 1 1 1 2 2 2 0 Myosin-like coiled-coil protein Rho_Binding PF08912.11 PIK56912.1 - 0.99 10.3 25.3 0.072 13.9 12.4 3.1 1 1 2 3 3 3 0 Rho Binding Exonuc_VII_L PF02601.15 PIK56912.1 - 2.7 7.5 11.6 3.3 7.2 11.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin_2 PF01920.20 PIK56912.1 - 3 7.8 22.9 2.6 8.0 15.0 3.3 2 1 0 2 2 2 0 Prefoldin subunit YabA PF06156.13 PIK56912.1 - 3.1 8.5 15.3 19 6.0 15.1 2.2 1 1 0 1 1 1 0 Initiation control protein YabA ARD PF03079.14 PIK56912.1 - 3.6 7.7 8.8 2.1 8.5 6.7 1.6 1 1 1 2 2 2 0 ARD/ARD' family DUF724 PF05266.14 PIK56912.1 - 3.8 7.3 16.8 1 9.2 13.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF883 PF05957.13 PIK56912.1 - 5.2 7.7 11.0 1.8 9.2 6.6 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ADIP PF11559.8 PIK56912.1 - 5.8 7.0 25.0 5.4 7.1 5.1 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.15 PIK56912.1 - 8.1 6.6 15.1 2.8 8.1 0.3 3.1 2 1 2 4 4 4 0 Basic region leucine zipper Cnn_1N PF07989.11 PIK56912.1 - 8.2 6.7 22.6 0.096 12.9 8.1 2.8 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Lectin_N PF03954.14 PIK56912.1 - 8.3 6.2 11.4 9.3 6.0 2.7 2.5 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain APG6_N PF17675.1 PIK56912.1 - 9.2 6.8 28.4 0.41 11.2 19.9 2.3 1 1 0 2 2 2 0 Apg6 coiled-coil region Gal-bind_lectin PF00337.22 PIK56913.1 - 5.2e-110 362.7 0.1 5e-36 123.2 0.1 3.0 3 0 0 3 3 3 3 Galactoside-binding lectin DUF4975 PF16346.5 PIK56913.1 - 1.6e-07 31.6 0.2 0.0084 16.2 0.1 3.1 2 1 1 3 3 3 3 Domain of unknown function (DUF4975) WIF PF02019.18 PIK56913.1 - 0.00058 19.6 0.0 1.4 8.6 0.0 2.8 2 1 0 2 2 2 2 WIF domain Gal-bind_lectin PF00337.22 PIK56914.1 - 4.4e-123 405.0 5.3 1e-40 138.4 0.8 3.0 3 0 0 3 3 3 3 Galactoside-binding lectin WIF PF02019.18 PIK56914.1 - 2.8e-07 30.3 0.1 0.13 12.0 0.0 3.4 3 0 0 3 3 3 3 WIF domain zf-CCHH PF10283.9 PIK56914.1 - 1.5 8.9 11.0 16 5.6 0.2 3.4 3 0 0 3 3 3 0 PBZ domain 7tm_3 PF00003.22 PIK56915.1 - 9.1e-56 189.2 16.6 1.2e-55 188.8 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Claudin_3 PF06653.11 PIK56915.1 - 0.0041 17.1 7.8 0.27 11.2 0.5 4.2 4 0 0 4 4 4 1 Tight junction protein, Claudin-like Lectin_C PF00059.21 PIK56915.1 - 0.0094 16.7 0.0 0.018 15.8 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain SPC25 PF06703.11 PIK56915.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) ANF_receptor PF01094.28 PIK56916.1 - 2.7e-33 115.5 3.4 3.1e-22 79.2 0.1 2.0 1 1 1 2 2 2 2 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK56916.1 - 4.9e-06 26.4 0.0 1.2e-05 25.2 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein GlcV_C_terminal PF17847.1 PIK56917.1 - 1.4e-06 28.7 0.4 40 4.8 0.0 7.3 1 1 8 9 9 9 0 Glucose ABC transporter C-terminal domain T_cell_tran_alt PF15128.6 PIK56917.1 - 0.0032 17.2 1.5 1.4e+02 2.4 0.0 5.9 1 1 7 8 8 8 0 T-cell leukemia translocation-altered RTP801_C PF07809.11 PIK56917.1 - 0.0049 16.8 1.5 6.4 6.7 0.1 3.5 1 1 4 5 5 5 1 RTP801 C-terminal region Arabino_trans_C PF14896.6 PIK56917.1 - 0.008 15.2 3.5 0.85 8.6 0.4 3.3 1 1 3 4 4 4 1 EmbC C-terminal domain DUF2863 PF11062.8 PIK56917.1 - 0.0087 14.5 3.1 2.1 6.6 0.2 3.1 1 1 3 4 4 4 3 Protein of unknown function (DUF2863) DUF1138 PF06592.13 PIK56917.1 - 0.0095 16.0 3.9 1.3e+02 2.7 0.0 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1138) DUF1028 PF06267.12 PIK56917.1 - 0.017 14.9 10.0 3.1 7.6 0.7 3.7 1 1 4 5 5 5 0 Family of unknown function (DUF1028) DUF2227 PF09988.9 PIK56917.1 - 0.03 14.2 9.6 16 5.3 0.2 4.7 1 1 6 7 7 7 0 Uncharacterized metal-binding protein (DUF2227) Peptidase_M73 PF12389.8 PIK56917.1 - 0.035 13.9 3.0 39 4.0 0.1 3.9 1 1 6 7 7 7 0 Camelysin metallo-endopeptidase Staphostatin_B PF09023.10 PIK56917.1 - 0.086 12.9 4.5 1.3e+02 2.6 0.0 5.4 1 1 7 8 8 8 0 Staphostatin B AdoMet_dc PF02675.15 PIK56917.1 - 0.15 12.3 5.7 16 5.8 0.1 4.4 2 1 4 6 6 6 0 S-adenosylmethionine decarboxylase DP-EP PF08985.11 PIK56917.1 - 0.25 11.5 4.8 5 7.3 0.8 3.1 1 1 3 4 4 4 0 DP-EP family SEFIR PF08357.11 PIK56917.1 - 2.1 8.6 6.1 15 5.9 0.7 3.0 1 1 2 4 4 4 0 SEFIR domain PAS_3 PF08447.12 PIK56918.1 - 8.3e-25 86.9 0.0 4.9e-17 62.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 PIK56918.1 - 3.9e-20 72.0 0.0 2.1e-15 56.8 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 PIK56918.1 - 2.2e-12 46.9 0.0 2e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK56918.1 - 7e-08 32.7 0.0 0.022 15.0 0.0 2.7 1 1 0 2 2 2 2 PAS domain PAS_4 PF08448.10 PIK56918.1 - 5e-07 30.0 0.0 0.036 14.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 PIK56918.1 - 0.17 12.6 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 PAS fold Ank_4 PF13637.6 PIK56919.1 - 1.7e-14 54.0 0.1 3.5e-09 37.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK56919.1 - 7.2e-14 52.2 0.0 1.3e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK56919.1 - 2.6e-13 48.8 0.4 9.4e-06 25.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 PIK56919.1 - 9.4e-13 48.1 0.3 5.3e-07 29.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.17 PIK56919.1 - 4.9e-12 45.4 0.0 1e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.30 PIK56919.1 - 1.2e-11 44.5 0.1 2.6e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.28 PIK56919.1 - 1.8e-10 40.2 2.2 3.9e-10 39.2 2.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK56919.1 - 1.1e-07 31.6 0.3 3e-07 30.2 0.3 1.7 1 0 0 1 1 1 1 Variant SH3 domain WSC PF01822.19 PIK56919.1 - 0.044 14.0 0.5 0.14 12.4 0.5 1.8 1 1 1 2 2 2 0 WSC domain DUF1043 PF06295.12 PIK56920.1 - 0.054 13.5 2.1 0.086 12.9 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) V-SNARE PF05008.15 PIK56920.1 - 0.13 12.7 2.7 0.24 11.8 2.7 1.4 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF3552 PF12072.8 PIK56920.1 - 1.6 8.1 4.7 2.3 7.6 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) RA PF00788.23 PIK56921.1 - 0.0013 19.3 0.3 0.41 11.3 0.1 2.1 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain IMS PF00817.20 PIK56922.1 - 2.3e-37 128.3 0.0 3e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 impB/mucB/samB family DUF1805 PF08827.11 PIK56922.1 - 0.058 13.7 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) IMS_HHH PF11798.8 PIK56923.1 - 0.0025 18.0 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 IMS family HHH motif C1_1 PF00130.22 PIK56924.1 - 8.1e-13 48.1 9.0 1.4e-12 47.2 9.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 PIK56924.1 - 4.9e-11 41.3 3.5 1.9e-06 27.0 0.3 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK56924.1 - 6.6e-10 38.1 0.6 6.3e-06 25.7 0.3 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK56924.1 - 1.7e-09 38.0 0.1 2.2e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK56924.1 - 3e-09 36.0 0.8 0.0026 17.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK56924.1 - 3.3e-05 23.6 2.3 0.0072 16.2 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair Cnn_1N PF07989.11 PIK56924.1 - 0.066 13.4 1.3 0.14 12.3 1.3 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 RasGEF PF00617.19 PIK56925.1 - 3.7e-37 128.2 0.1 4.3e-37 128.0 0.1 1.0 1 0 0 1 1 1 1 RasGEF domain Hemocyanin_N PF03722.14 PIK56925.1 - 0.04 14.4 0.0 0.069 13.7 0.0 1.3 1 0 0 1 1 1 0 Hemocyanin, all-alpha domain TMP_2 PF06791.13 PIK56925.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Prophage tail length tape measure protein ANF_receptor PF01094.28 PIK56926.1 - 2.3e-08 33.5 0.0 3.2e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region ANF_receptor PF01094.28 PIK56927.1 - 5.3e-32 111.3 0.2 6.4e-32 111.0 0.2 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK56927.1 - 8.4e-09 35.5 0.0 1.1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein FerB PF08150.12 PIK56927.1 - 0.025 15.1 0.1 0.056 14.1 0.1 1.6 1 0 0 1 1 1 0 FerB (NUC096) domain RGS-like PF09128.11 PIK56927.1 - 0.14 11.9 0.2 0.22 11.2 0.2 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain ANF_receptor PF01094.28 PIK56929.1 - 0.0001 21.6 0.5 0.00013 21.2 0.5 1.3 1 1 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 PIK56930.1 - 1.6e-20 73.9 16.7 2.2e-20 73.4 16.7 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR UPF0220 PF05255.11 PIK56930.1 - 2.5 7.6 11.0 0.23 11.0 5.7 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0220) NrsF PF06532.11 PIK56930.1 - 4 7.1 8.1 0.51 10.0 0.3 2.7 2 1 0 2 2 2 0 Negative regulator of sigma F Imm17 PF15562.6 PIK56930.1 - 8.1 6.4 16.4 0.68 9.8 0.3 3.0 3 0 0 3 3 3 0 Immunity protein 17 7tm_3 PF00003.22 PIK56931.1 - 1.5e-16 60.9 19.3 1.9e-16 60.5 19.3 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Oxidored_q3 PF00499.20 PIK56931.1 - 0.41 10.4 9.3 0.032 14.0 1.9 2.4 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 zf-C3HC4_3 PF13920.6 PIK56932.1 - 3.6e-11 42.7 5.2 5.6e-11 42.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK56932.1 - 3.5e-10 40.0 9.4 5.9e-10 39.3 9.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 PIK56932.1 - 4.4e-10 39.4 6.9 9.4e-10 38.4 6.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK56932.1 - 2e-09 37.1 9.4 3.4e-09 36.4 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK56932.1 - 6.1e-09 35.6 8.4 1e-08 34.9 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK56932.1 - 5.5e-08 33.0 5.0 1e-07 32.1 5.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 PIK56932.1 - 1.3e-07 31.5 5.9 2.5e-07 30.5 5.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK56932.1 - 8.9e-07 28.7 8.2 4.8e-06 26.3 8.4 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK56932.1 - 1.9e-06 27.9 9.2 4e-06 26.9 9.2 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 PIK56932.1 - 0.001 19.1 1.6 0.002 18.2 1.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 PIK56932.1 - 0.0039 17.0 3.2 0.0042 16.9 1.7 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 PIK56932.1 - 0.031 14.1 4.2 0.087 12.7 4.3 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 PIK56932.1 - 0.034 13.8 4.2 0.063 12.9 4.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 PIK56932.1 - 0.09 12.6 7.0 1.3 8.8 4.4 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 PIK56932.1 - 0.15 12.1 5.2 0.25 11.4 5.2 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-RING_10 PF16685.5 PIK56932.1 - 0.2 11.8 5.4 0.54 10.4 5.4 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 UBZ_FAAP20 PF15750.5 PIK56932.1 - 0.42 10.6 3.7 15 5.6 0.4 2.7 3 0 0 3 3 2 0 Ubiquitin-binding zinc-finger TMEM251 PF15190.6 PIK56932.1 - 0.6 10.1 5.1 0.64 10.0 0.6 2.4 2 0 0 2 2 2 0 Transmembrane protein 251 zf-C3HC4_5 PF17121.5 PIK56932.1 - 1.3 8.9 9.2 7.8 6.5 9.2 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIB PF13453.6 PIK56932.1 - 6.2 6.2 10.7 0.51 9.7 4.5 2.4 1 1 1 2 2 2 0 Transcription factor zinc-finger DUF4536 PF15055.6 PIK56933.1 - 0.019 15.2 1.0 0.14 12.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) SpoU_methylase PF00588.19 PIK56934.1 - 1.9e-28 99.4 0.0 3e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 PIK56934.1 - 4.7e-05 23.6 0.0 0.0014 18.9 0.0 3.1 3 1 0 3 3 3 1 RNA 2'-O ribose methyltransferase substrate binding WD40 PF00400.32 PIK56935.1 - 2.4e-14 53.5 10.3 6.6e-07 29.9 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK56935.1 - 0.00072 19.8 0.1 11 6.4 0.0 3.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain CBM26 PF16738.5 PIK56935.1 - 1.2 9.4 6.6 20 5.5 0.3 3.6 4 0 0 4 4 4 0 Starch-binding module 26 Acyl-CoA_dh_1 PF00441.24 PIK56936.1 - 8.9e-49 165.5 5.4 1.4e-48 164.9 5.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK56936.1 - 1.9e-31 109.0 0.0 5.6e-31 107.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK56936.1 - 3.8e-25 88.7 1.7 3.8e-25 88.7 1.7 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK56936.1 - 1.7e-13 50.6 0.1 3.6e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Pkinase PF00069.25 PIK56937.1 - 1.7e-71 240.7 0.0 2.5e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56937.1 - 1.1e-34 119.9 0.1 1.9e-34 119.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK56937.1 - 1.5e-05 24.5 0.1 2.9e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK56937.1 - 0.007 16.0 0.2 0.017 14.8 0.2 1.6 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 PIK56937.1 - 0.011 14.7 0.9 0.018 14.0 0.9 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 PIK56937.1 - 0.011 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Rib_recp_KP_reg PF05104.12 PIK56938.1 - 1.2 10.1 17.4 1.7 9.7 16.9 1.7 1 1 0 1 1 1 0 Ribosome receptor lysine/proline rich region FAM178 PF14816.6 PIK56938.1 - 5.3 5.9 6.2 7.8 5.4 6.2 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 7tm_1 PF00001.21 PIK56939.1 - 9.6e-08 31.7 15.7 1.3e-07 31.2 15.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK56939.1 - 4.2e-05 23.1 1.4 4.2e-05 23.1 1.4 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx GPR_Gpa2_C PF11970.8 PIK56939.1 - 8.3e-05 22.6 3.0 0.013 15.6 0.4 2.5 2 0 0 2 2 2 2 G protein-coupled glucose receptor regulating Gpa2 C-term LPP PF04728.13 PIK56941.1 - 0.085 13.3 3.2 14 6.2 0.2 4.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper CASP_C PF08172.12 PIK56942.1 - 2e-60 204.2 11.2 5.1e-60 202.9 11.2 1.6 1 1 0 1 1 1 1 CASP C terminal CtIP_N PF10482.9 PIK56942.1 - 0.0067 16.5 3.2 0.0067 16.5 3.2 1.9 2 0 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain Scaffolding_pro PF11418.8 PIK56942.1 - 0.026 15.1 0.9 0.23 12.1 0.2 2.2 2 0 0 2 2 2 0 Phi29 scaffolding protein MotB_plug PF13677.6 PIK56942.1 - 0.04 13.5 1.9 0.081 12.5 1.9 1.5 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Nodulin_late PF07127.11 PIK56942.1 - 0.065 13.6 3.0 0.11 12.8 3.0 1.4 1 0 0 1 1 1 0 Late nodulin protein TMF_DNA_bd PF12329.8 PIK56942.1 - 0.23 11.5 4.3 0.89 9.6 0.2 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Viral_Beta_CD PF04530.12 PIK56942.1 - 0.35 11.2 1.5 24 5.3 0.0 3.0 3 0 0 3 3 3 0 Viral Beta C/D like family bZIP_2 PF07716.15 PIK56942.1 - 0.4 10.8 6.3 0.88 9.7 5.3 2.2 1 1 1 2 2 2 0 Basic region leucine zipper KLRAQ PF10205.9 PIK56942.1 - 0.43 10.9 7.0 0.059 13.6 2.1 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF2205 PF10224.9 PIK56942.1 - 0.84 9.7 7.0 0.41 10.7 3.3 2.4 2 1 0 2 2 2 0 Short coiled-coil protein Golgin_A5 PF09787.9 PIK56942.1 - 0.95 8.9 13.2 0.92 8.9 8.7 2.4 2 1 0 2 2 2 0 Golgin subfamily A member 5 DivIC PF04977.15 PIK56942.1 - 2.3 8.0 9.1 0.31 10.8 1.8 2.5 2 0 0 2 2 2 0 Septum formation initiator CUT PF02376.15 PIK56943.1 - 6.7e-45 151.1 1.9 1.7e-22 79.4 0.0 3.1 3 0 0 3 3 3 2 CUT domain SNARE PF05739.19 PIK56943.1 - 0.42 10.7 1.4 1.1 9.3 0.4 2.3 2 0 0 2 2 2 0 SNARE domain Tropomyosin_1 PF12718.7 PIK56943.1 - 1.2 9.2 74.4 0.052 13.7 25.6 4.6 3 1 2 5 5 5 0 Tropomyosin like DUF2935 PF11155.8 PIK56943.1 - 4.4 7.7 10.8 6.3e+02 0.7 8.9 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Prok_Ub PF14454.6 PIK56944.1 - 0.054 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DUF3475 PF11961.8 PIK56944.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3475) DUF5617 PF18493.1 PIK56944.1 - 0.064 13.4 0.9 8.2 6.6 0.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5617) Hit1_C PF18268.1 PIK56944.1 - 0.1 12.7 0.0 0.34 11.1 0.0 1.9 1 0 0 1 1 1 0 Hit1 C-terminal PriA_CRR PF18319.1 PIK56945.1 - 0.073 13.1 0.2 0.073 13.1 0.2 2.0 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain RRN3 PF05327.11 PIK56945.1 - 0.11 11.0 2.7 0.15 10.5 2.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ZZ PF00569.17 PIK56945.1 - 0.22 11.3 2.6 11 5.9 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, ZZ type zf-ACC PF17848.1 PIK56945.1 - 4.2 7.5 6.1 0.83 9.8 0.4 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 PIK56945.1 - 4.5 7.0 7.1 0.69 9.6 0.9 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Nup88 PF10168.9 PIK56946.1 - 2.6e-176 587.5 0.4 3e-176 587.3 0.4 1.0 1 0 0 1 1 1 1 Nuclear pore component Nup88 PF10168.9 PIK56947.1 - 1.9e-09 35.9 1.5 2e-09 35.8 1.5 1.0 1 0 0 1 1 1 1 Nuclear pore component FlaC_arch PF05377.11 PIK56947.1 - 0.016 15.6 1.7 1.7 9.1 1.7 2.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) TPR_2 PF07719.17 PIK56948.1 - 1.2e-13 50.0 10.7 2.9e-07 30.1 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56948.1 - 3.9e-09 35.9 11.6 8e-06 25.5 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 PIK56948.1 - 1.1e-06 28.8 0.0 2.5e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_16 PF13432.6 PIK56948.1 - 9.5e-06 26.2 1.1 0.062 14.0 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK56948.1 - 1.3e-05 25.4 3.4 0.42 10.9 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56948.1 - 0.00011 22.1 4.2 0.014 15.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK56948.1 - 0.0011 19.4 3.3 0.049 14.1 1.9 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK56948.1 - 0.002 18.6 3.5 4.6 8.1 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK56948.1 - 0.0026 18.5 1.2 0.43 11.5 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56948.1 - 0.004 17.1 5.1 2 8.7 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK56948.1 - 0.0055 16.9 5.5 0.0055 16.9 5.5 2.5 2 1 1 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK56948.1 - 0.0082 15.8 9.2 0.67 9.7 0.2 3.4 3 0 0 3 3 3 1 TPR repeat MIT PF04212.18 PIK56948.1 - 0.02 15.0 4.3 0.15 12.1 0.3 2.9 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain Ric8 PF10165.9 PIK56948.1 - 0.032 13.3 4.0 0.98 8.4 1.4 2.2 1 1 1 2 2 2 0 Guanine nucleotide exchange factor synembryn DUF2031 PF09592.10 PIK56948.1 - 0.076 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Fis1_TPR_C PF14853.6 PIK56948.1 - 0.54 10.4 5.0 5.2 7.2 0.2 3.0 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 PIK56948.1 - 0.97 9.5 9.2 1.5 8.9 1.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CDC50 PF03381.15 PIK56949.1 - 1.3e-30 106.9 1.1 1.6e-30 106.6 0.7 1.3 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CDC50 PF03381.15 PIK56950.1 - 3.8e-38 131.6 0.3 4.5e-38 131.4 0.3 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Acatn PF13000.7 PIK56950.1 - 0.044 12.3 0.1 0.052 12.0 0.1 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 VPS9 PF02204.18 PIK56951.1 - 8.1e-30 103.1 0.0 2.5e-29 101.5 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 PIK56951.1 - 9.9e-19 67.4 1.1 5.3e-18 65.1 0.9 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) zf-A20 PF01754.16 PIK56951.1 - 1.2e-13 50.7 4.9 2.1e-13 49.9 4.9 1.4 1 0 0 1 1 1 1 A20-like zinc finger Luteo_PO PF04662.13 PIK56951.1 - 0.062 13.0 3.3 1.6 8.3 0.7 2.3 2 0 0 2 2 2 0 Luteovirus P0 protein Egg_lysin PF01303.17 PIK56951.1 - 0.12 12.6 4.6 0.055 13.7 1.3 2.1 2 0 0 2 2 2 0 Egg lysin (Sperm-lysin) DUF3482 PF11981.8 PIK56951.1 - 0.32 10.3 6.7 0.056 12.8 2.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) DUF2207 PF09972.9 PIK56951.1 - 0.42 9.3 1.7 0.31 9.8 0.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) YtxH PF12732.7 PIK56951.1 - 0.85 10.2 4.7 14 6.3 0.5 3.2 2 1 0 2 2 2 0 YtxH-like protein DUF445 PF04286.12 PIK56951.1 - 6.7 6.4 12.7 4.5 7.0 7.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) GMP_PDE_delta PF05351.11 PIK56952.1 - 1.4e-56 191.0 0.9 1.6e-56 190.8 0.9 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit RF-1 PF00472.20 PIK56953.1 - 1.2e-11 44.6 1.5 2.3e-11 43.6 1.0 1.8 1 1 0 1 1 1 1 RF-1 domain HTH_Tnp_IS630 PF01710.16 PIK56953.1 - 0.0029 17.6 0.5 0.0029 17.6 0.5 1.6 2 0 0 2 2 2 1 Transposase Glyco_transf_10 PF00852.19 PIK56954.1 - 6.2e-43 146.6 0.9 9.6e-43 145.9 0.9 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term RVT_1 PF00078.27 PIK56955.1 - 4e-08 33.1 0.0 6.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK56955.1 - 0.0043 17.1 0.4 0.014 15.4 0.2 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK56956.1 - 3.4e-17 62.7 0.0 5.6e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Glyco_transf_10 PF00852.19 PIK56957.1 - 1.7e-32 112.5 0.0 2.6e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Pyr_redox_2 PF07992.14 PIK56958.1 - 1.1e-48 166.0 0.0 1.3e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 PIK56958.1 - 6.9e-27 93.9 0.0 1.3e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 PIK56958.1 - 1.8e-17 63.7 0.2 4.4e-13 49.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK56958.1 - 1.2e-07 31.4 0.0 0.0005 19.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK56958.1 - 2.9e-06 26.6 1.8 1.5e-05 24.3 2.1 2.0 1 1 1 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 PIK56958.1 - 7.7e-05 22.0 0.0 0.0011 18.2 0.0 2.4 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 PIK56958.1 - 0.00013 20.8 0.2 0.00066 18.5 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 PIK56958.1 - 0.00035 19.9 0.1 0.012 14.9 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 PIK56958.1 - 0.00044 19.6 0.1 0.00094 18.5 0.1 1.5 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 PIK56958.1 - 0.0075 15.7 2.4 0.0086 15.5 1.4 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK56958.1 - 0.012 14.8 1.3 0.04 13.0 1.3 1.8 1 1 0 1 1 1 0 Glucose inhibited division protein A DAO PF01266.24 PIK56958.1 - 0.021 14.4 0.7 0.053 13.1 0.6 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 PIK56958.1 - 0.028 14.6 0.6 0.028 14.6 0.6 1.9 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 PIK56958.1 - 0.14 12.7 0.1 5.2 7.6 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding NYD-SP28_assoc PF14775.6 PIK56958.1 - 0.15 12.2 0.4 0.29 11.2 0.4 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain Lycopene_cycl PF05834.12 PIK56958.1 - 0.23 10.5 0.3 0.35 9.9 0.3 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein PHD PF00628.29 PIK56959.1 - 1.7e-17 63.0 29.0 2.3e-09 37.0 17.3 2.5 2 0 0 2 2 2 2 PHD-finger PHF12_MRG_bd PF16737.5 PIK56959.1 - 5.2e-14 51.7 1.0 9.7e-14 50.8 1.0 1.4 1 0 0 1 1 1 1 PHD finger protein 12 MRG binding domain C1_1 PF00130.22 PIK56959.1 - 0.0004 20.2 16.6 0.0012 18.7 1.7 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 PIK56959.1 - 0.0096 15.5 0.0 0.0096 15.5 0.0 3.2 4 0 0 4 4 4 2 PHD-finger zf-PHD-like PF15446.6 PIK56959.1 - 3.5 7.2 17.8 1.6 8.3 1.0 3.5 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain FHA PF00498.26 PIK56960.1 - 3.3e-05 24.1 0.1 0.00015 22.0 0.1 2.0 2 0 0 2 2 2 1 FHA domain Ldh_1_C PF02866.18 PIK56961.1 - 6.7e-55 185.5 0.0 1.4e-54 184.6 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 PIK56961.1 - 1.7e-45 154.6 0.0 2.7e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 PIK56961.1 - 0.00074 18.6 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 PIK56961.1 - 0.003 17.5 0.1 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 PIK56961.1 - 0.023 15.1 0.1 0.099 13.1 0.0 2.0 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TPR_12 PF13424.6 PIK56962.1 - 1.2e-25 89.5 18.5 6.8e-11 42.3 0.3 7.4 3 3 3 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 PIK56962.1 - 7.8e-21 73.3 1.1 2.2e-08 33.7 0.1 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 PIK56962.1 - 5.2e-09 35.5 17.9 1.5e-05 24.6 1.0 7.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK56962.1 - 8.4e-08 31.8 14.9 0.00059 19.8 1.3 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK56962.1 - 2.5e-07 30.3 6.5 0.0069 16.3 0.1 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK56962.1 - 1e-05 25.3 10.5 0.79 10.0 0.4 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK56962.1 - 0.00084 18.8 7.6 0.5 9.7 0.5 3.6 1 1 0 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 PIK56962.1 - 0.024 15.0 0.3 7.3 7.2 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat GST_C_3 PF14497.6 PIK56963.1 - 5.3e-17 61.8 0.4 8.2e-17 61.2 0.4 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK56963.1 - 2e-06 27.9 0.2 3.5e-06 27.1 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TetR_C_7 PF14246.6 PIK56963.1 - 0.0018 18.3 0.0 0.0046 17.0 0.0 1.7 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal domain GST_C_2 PF13410.6 PIK56963.1 - 0.0025 17.8 0.0 0.0049 16.9 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK56963.1 - 0.048 14.0 1.3 0.3 11.5 0.0 2.5 3 0 0 3 3 3 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 PIK56963.1 - 0.12 13.0 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FliN_N PF16973.5 PIK56963.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliN N-terminal Lectin_C PF00059.21 PIK56964.1 - 6.1e-13 49.5 3.2 1.3e-12 48.4 3.2 1.5 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK56964.1 - 0.13 11.8 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like CEP209_CC5 PF16574.5 PIK56967.1 - 0.0098 16.1 3.4 0.018 15.2 3.4 1.4 1 0 0 1 1 1 1 Coiled-coil region of centrosome protein CE290 Thiolase_N PF00108.23 PIK56968.1 - 5.7e-97 324.1 2.8 8.5e-97 323.6 2.8 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK56968.1 - 8.9e-52 173.9 1.6 1.2e-50 170.3 1.0 2.4 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 PIK56968.1 - 0.00014 22.0 0.2 0.0011 19.1 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 PIK56968.1 - 0.0017 17.9 2.7 0.1 12.2 2.7 2.5 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 PIK56968.1 - 0.0071 16.3 1.8 14 5.7 0.0 4.5 3 2 1 4 4 4 1 Beta-ketoacyl synthase, C-terminal domain Dodecin PF07311.12 PIK56968.1 - 0.085 13.1 0.1 0.38 11.0 0.1 2.1 1 1 1 2 2 2 0 Dodecin ACP_syn_III PF08545.10 PIK56968.1 - 0.15 11.9 0.7 5.6 6.9 0.1 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAP18 PF06487.12 PIK56969.1 - 5.9e-39 133.4 0.0 7.8e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Tctex-1 PF03645.13 PIK56970.1 - 7.7e-34 116.0 0.8 7.7e-34 116.0 0.8 1.4 2 0 0 2 2 2 1 Tctex-1 family PTP2 PF17022.5 PIK56970.1 - 0.012 15.3 2.1 0.02 14.5 0.1 1.9 1 1 1 2 2 2 0 Polar tube protein 2 from Microsporidia DUF507 PF04368.13 PIK56970.1 - 0.014 15.3 0.0 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF507) Anticodon_1 PF08264.13 PIK56970.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA C2 PF00168.30 PIK56973.1 - 3.8e-40 136.3 0.2 1.1e-18 67.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain Orbi_VP5 PF00901.17 PIK56973.1 - 0.033 12.6 0.1 0.064 11.6 0.1 1.4 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 AhpC-TSA PF00578.21 PIK56974.1 - 1.4e-36 125.1 0.0 2.4e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 PIK56974.1 - 1.4e-14 54.0 0.0 2e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 PIK56974.1 - 3.6e-12 45.9 0.0 6.8e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Trimer_CC PF08954.11 PIK56975.1 - 0.0039 16.7 0.1 0.012 15.2 0.1 1.8 1 0 0 1 1 1 1 Trimerisation motif Spc7 PF08317.11 PIK56975.1 - 0.086 11.7 6.1 2.4 6.9 0.3 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 PIK56975.1 - 5.2 7.5 8.0 8.5 6.8 1.8 2.5 2 0 0 2 2 2 0 Fez1 5_nucleotid_C PF02872.18 PIK56976.1 - 1.1e-36 126.4 0.0 2e-36 125.6 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 PIK56976.1 - 6.6e-09 36.6 0.1 1e-08 36.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nucleoporin_FG PF13634.6 PIK56977.1 - 0.081 13.8 1.2 0.081 13.8 1.2 1.6 2 0 0 2 2 2 0 Nucleoporin FG repeat region Pkinase PF00069.25 PIK56979.1 - 7.3e-29 100.9 0.0 9.5e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK56979.1 - 3.5e-16 59.3 0.0 4.5e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK56979.1 - 8.3e-05 22.0 0.0 0.00011 21.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK56979.1 - 0.073 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK56979.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Sugar_tr PF00083.24 PIK56980.1 - 5.1e-23 81.7 19.3 6.5e-23 81.3 19.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK56980.1 - 9.5e-13 47.8 34.1 9.6e-10 37.9 22.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK56981.1 - 4.7e-25 88.4 18.1 4.7e-25 88.4 18.1 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK56981.1 - 4.7e-23 81.7 38.5 3.8e-21 75.4 27.3 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF1381 PF07129.11 PIK56982.1 - 0.0076 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1381) Neurexophilin PF06312.12 PIK56983.1 - 3.1e-10 39.9 0.0 7.2e-10 38.7 0.0 1.6 1 1 0 1 1 1 1 Neurexophilin Conotoxin PF02950.17 PIK56984.1 - 0.00042 21.3 2.5 0.00063 20.7 2.5 1.4 1 1 0 1 1 1 1 Conotoxin Toxin_35 PF10530.9 PIK56984.1 - 2.4 8.2 13.2 10 6.2 13.2 1.9 1 1 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold TTL PF03133.15 PIK56985.1 - 1.9e-79 266.8 0.3 1.9e-79 266.8 0.3 1.6 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK56985.1 - 1.3e-07 31.2 0.0 0.00015 21.1 0.0 2.6 3 0 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK56985.1 - 0.00022 20.6 0.0 0.012 14.8 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Serine_rich PF08824.10 PIK56985.1 - 0.00096 19.2 1.1 0.0039 17.2 0.1 2.1 2 0 0 2 2 2 1 Serine rich protein interaction domain ATP-grasp_3 PF02655.14 PIK56985.1 - 0.055 13.5 0.0 0.84 9.7 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain Peptidase_M1_N PF17900.1 PIK56986.1 - 8.1e-18 65.3 0.4 1.5e-17 64.4 0.4 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Metal_resist PF13801.6 PIK56987.1 - 0.018 15.3 3.9 0.22 11.7 0.4 2.9 2 0 0 2 2 2 0 Heavy-metal resistance DUF4377 PF14302.6 PIK56988.1 - 0.069 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4377) K_channel_TID PF07941.11 PIK56988.1 - 0.26 11.8 5.0 1.1 9.8 5.0 2.0 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Menin PF05053.13 PIK56988.1 - 1.5 7.1 23.5 0.35 9.2 12.6 2.6 3 0 0 3 3 3 0 Menin STI1 PF17830.1 PIK56989.1 - 1.9e-13 50.1 0.9 7.6e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 STI1 domain PLU-1 PF08429.11 PIK56989.1 - 0.053 12.7 0.2 0.053 12.7 0.2 2.6 3 0 0 3 3 3 0 PLU-1-like protein ING PF12998.7 PIK56989.1 - 0.2 12.2 6.2 0.8 10.3 0.2 3.1 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding NifU_N PF01592.16 PIK56990.1 - 5.3e-46 155.9 0.1 6.1e-46 155.7 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DUF3659 PF12396.8 PIK56990.1 - 0.046 13.6 0.3 0.53 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Ribosomal_L13 PF00572.18 PIK56991.1 - 5.9e-11 42.7 0.2 1.3e-09 38.3 0.0 2.4 2 1 0 2 2 2 1 Ribosomal protein L13 CHORD PF04968.12 PIK56992.1 - 7.5e-51 170.7 30.4 1.9e-26 92.5 8.5 2.5 3 0 0 3 3 3 2 CHORD CS PF04969.16 PIK56992.1 - 1.8e-09 38.5 0.3 3.9e-09 37.4 0.0 1.7 2 0 0 2 2 2 1 CS domain BTK PF00779.19 PIK56992.1 - 0.61 10.0 14.7 2.1 8.2 0.5 3.9 3 1 0 3 3 3 0 BTK motif MCD PF05292.11 PIK56993.1 - 1.2e-96 323.2 0.0 2.7e-96 322.1 0.0 1.5 2 0 0 2 2 2 1 Malonyl-CoA decarboxylase C-terminal domain MCD_N PF17408.2 PIK56993.1 - 7e-17 61.3 0.5 2e-16 59.9 0.1 2.0 2 0 0 2 2 2 1 Malonyl-CoA decarboxylase N-terminal domain SIX1_SD PF16878.5 PIK56993.1 - 0.031 14.8 0.1 2.4 8.7 0.0 2.7 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain MAPEG PF01124.18 PIK56994.1 - 6.4e-21 74.6 0.0 9.3e-21 74.1 0.0 1.3 1 1 0 1 1 1 1 MAPEG family GCFC PF07842.12 PIK56995.1 - 2.6e-29 102.7 1.7 1.6e-28 100.1 1.7 2.2 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein Herpes_UL74 PF07982.12 PIK56995.1 - 0.028 13.4 0.0 0.051 12.5 0.0 1.3 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Herpes_UL56 PF04534.12 PIK56995.1 - 1.8 8.0 9.6 3.3 7.2 9.6 1.3 1 0 0 1 1 1 0 Herpesvirus UL56 protein CTP_synth_N PF06418.14 PIK56996.1 - 1.2e-111 372.2 0.6 7.2e-111 369.7 0.6 1.9 1 1 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 PIK56996.1 - 5.6e-58 195.8 0.1 9.3e-58 195.1 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 PIK56996.1 - 1e-07 32.0 0.1 1.9e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 PIK56996.1 - 0.011 15.8 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Cullin PF00888.22 PIK56997.1 - 1.1e-181 605.7 27.0 1.3e-181 605.4 27.0 1.1 1 0 0 1 1 1 1 Cullin family FAD_SOX PF18371.1 PIK56997.1 - 5.1 7.5 8.6 8.5 6.8 0.7 3.6 4 0 0 4 4 4 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase T4_deiodinase PF00837.17 PIK56998.1 - 3.2e-24 85.5 0.0 4.5e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Iodothyronine deiodinase ADH_N PF08240.12 PIK56999.1 - 2.2e-07 30.7 0.2 3.7e-07 30.0 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK56999.1 - 2.9e-07 30.5 0.0 6.6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 PIK56999.1 - 0.0004 21.5 0.0 0.0029 18.7 0.0 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 PIK56999.1 - 0.024 13.9 0.1 0.039 13.2 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain VirB7 PF17413.2 PIK56999.1 - 0.053 12.8 0.2 0.12 11.7 0.2 1.5 1 0 0 1 1 1 0 Outer membrane lipoprotein virB7 Ntox15 PF15604.6 PIK56999.1 - 0.083 13.0 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Novel toxin 15 2-Hacid_dh_C PF02826.19 PIK56999.1 - 0.095 12.0 0.1 0.27 10.6 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Macro PF01661.21 PIK57000.1 - 8.6e-22 77.4 0.0 1.2e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 Macro domain CRAL_TRIO_2 PF13716.6 PIK57001.1 - 3.2e-35 121.3 3.0 3.7e-35 121.1 3.0 1.0 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 PIK57001.1 - 2e-05 24.4 0.5 2.9e-05 23.8 0.5 1.3 1 1 0 1 1 1 1 CRAL/TRIO domain PH PF00169.29 PIK57002.1 - 1.2e-15 57.8 0.1 4.6e-15 56.0 0.1 2.1 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 PIK57002.1 - 3.6e-10 40.2 0.0 1e-09 38.8 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain Tiam_CC_Ex PF18385.1 PIK57002.1 - 6.7e-08 32.8 0.2 1.6e-07 31.6 0.2 1.6 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain WH1 PF00568.23 PIK57002.1 - 1.4e-05 25.0 0.0 3.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 WH1 domain FPV060 PF17614.2 PIK57002.1 - 0.042 13.2 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 Viral CC-type chemokine Arf PF00025.21 PIK57003.1 - 3.8e-53 179.5 0.2 4.3e-53 179.4 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 PIK57003.1 - 2.2e-13 50.5 0.0 3.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK57003.1 - 1.1e-12 47.8 0.1 1.3e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 PIK57003.1 - 2.3e-12 46.7 0.2 3e-12 46.3 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK57003.1 - 6.1e-11 42.1 3.2 1.1e-06 28.0 0.5 2.4 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 PIK57003.1 - 1.2e-07 31.7 0.0 1.8e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 PIK57003.1 - 1.5e-06 27.8 0.2 1.8e-06 27.5 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK57003.1 - 0.00013 21.6 0.2 0.001 18.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 PIK57003.1 - 0.0012 18.4 0.7 0.0038 16.8 0.7 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 PIK57003.1 - 0.034 14.4 0.2 0.16 12.2 0.2 1.9 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK57003.1 - 0.037 13.9 0.3 0.75 9.7 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 PIK57003.1 - 0.059 13.9 0.1 0.083 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain Thioredoxin_9 PF14595.6 PIK57003.1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin AAA_7 PF12775.7 PIK57003.1 - 0.13 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MobB PF03205.14 PIK57003.1 - 0.14 12.0 0.1 0.2 11.5 0.1 1.4 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 PIK57003.1 - 0.15 11.7 0.1 0.7 9.5 0.1 2.0 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain RrnaAD PF00398.20 PIK57004.1 - 8.6e-28 97.1 0.0 1.1e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Dopey_N PF04118.14 PIK57008.1 - 1e-101 340.1 0.1 1.9e-101 339.2 0.1 1.5 1 0 0 1 1 1 1 Dopey, N-terminal Gln-synt_C PF00120.24 PIK57009.1 - 1.4e-83 280.8 0.0 1.6e-83 280.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain FMN_dh PF01070.18 PIK57010.1 - 1.3e-54 185.6 0.8 1.6e-54 185.2 0.8 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK57010.1 - 1.1e-07 31.2 1.6 2.3e-07 30.1 0.9 1.7 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK57010.1 - 1.5e-05 24.3 0.0 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK57010.1 - 2e-05 24.1 0.6 2.3e-05 24.0 0.6 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK57010.1 - 0.0012 18.4 0.1 0.002 17.6 0.1 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein Aminotran_1_2 PF00155.21 PIK57010.1 - 0.024 13.8 0.0 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II FMN_dh PF01070.18 PIK57011.1 - 1.7e-33 116.2 2.0 1.8e-33 116.0 2.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK57011.1 - 1e-07 31.3 1.4 1.4e-07 30.8 1.4 1.3 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK57011.1 - 1.7e-06 27.5 0.1 2.2e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK57011.1 - 5.6e-05 22.7 3.2 6.4e-05 22.5 3.2 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK57011.1 - 0.003 17.0 0.1 0.0053 16.3 0.1 1.5 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 PIK57011.1 - 0.026 13.9 0.4 0.04 13.2 0.4 1.4 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 PIK57011.1 - 0.026 13.7 0.1 0.036 13.3 0.1 1.2 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase MFS_1 PF07690.16 PIK57013.1 - 9.7e-28 97.1 33.3 1.3e-16 60.4 11.7 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4229 PF14012.6 PIK57013.1 - 0.15 12.2 0.1 0.15 12.2 0.1 4.2 4 1 2 6 6 6 0 Protein of unknown function (DUF4229) ASH PF15780.5 PIK57014.1 - 6e-06 26.4 0.0 0.0054 16.9 0.2 2.5 2 0 0 2 2 2 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 PIK57014.1 - 0.00028 21.0 0.0 0.00066 19.8 0.0 1.6 1 0 0 1 1 1 1 Flagellar-associated PapD-like LRR_4 PF12799.7 PIK57016.1 - 9e-07 29.1 13.1 0.026 15.0 0.9 5.4 1 1 5 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK57016.1 - 0.00089 19.5 7.3 0.096 13.3 0.0 5.3 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 PIK57016.1 - 0.007 16.3 5.8 7.9 6.8 0.0 5.1 6 0 0 6 6 6 2 Leucine Rich repeat DNA_primase_lrg PF04104.14 PIK57016.1 - 0.018 14.5 0.3 0.08 12.3 0.1 1.9 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit LRR_8 PF13855.6 PIK57016.1 - 0.081 12.7 5.3 26 4.7 4.8 3.9 3 1 1 4 4 4 0 Leucine rich repeat Bindin PF02084.15 PIK57017.1 - 2.9e-33 116.1 0.0 1.1e-32 114.3 0.0 2.0 1 0 0 1 1 1 1 Bindin Nup88 PF10168.9 PIK57017.1 - 3e-29 101.4 120.8 0.0001 20.3 7.5 9.2 9 0 0 9 9 9 9 Nuclear pore component TolA_bind_tri PF16331.5 PIK57017.1 - 1.1e-11 44.7 75.9 0.25 11.5 1.1 11.5 9 0 0 9 9 9 9 TolA binding protein trimerisation ATG16 PF08614.11 PIK57017.1 - 1.3e-11 45.1 138.5 0.099 12.9 7.1 11.6 9 4 0 9 9 9 7 Autophagy protein 16 (ATG16) HTH_Tnp_Tc3_2 PF01498.18 PIK57017.1 - 6.5e-11 42.3 7.5 37 4.7 0.0 10.4 9 0 0 9 9 9 0 Transposase KxDL PF10241.9 PIK57017.1 - 1.9e-09 37.6 67.6 0.3 11.4 0.6 11.7 11 0 0 11 11 9 9 Uncharacterized conserved protein UPF0242 PF06785.11 PIK57017.1 - 9.7e-05 22.6 149.7 0.37 10.9 10.4 9.4 9 0 0 9 9 9 8 Uncharacterised protein family (UPF0242) N-terminus DUF3926 PF13080.6 PIK57017.1 - 0.00017 21.4 50.7 2.8 7.9 0.2 10.7 10 0 0 10 10 10 5 Protein of unknown function (DUF3926) Golgin_A5 PF09787.9 PIK57017.1 - 0.00022 20.8 127.7 0.12 11.8 4.5 9.3 1 1 4 9 9 9 8 Golgin subfamily A member 5 FliD_N PF02465.18 PIK57017.1 - 0.00029 21.5 44.3 14 6.5 0.2 11.7 10 1 0 10 10 9 0 Flagellar hook-associated protein 2 N-terminus Fib_alpha PF08702.10 PIK57017.1 - 0.0011 19.1 97.7 0.89 9.7 4.5 9.8 9 0 0 9 9 9 8 Fibrinogen alpha/beta chain family ADIP PF11559.8 PIK57017.1 - 0.039 14.0 121.8 1.2 9.2 5.1 11.2 9 2 0 9 9 9 0 Afadin- and alpha -actinin-Binding BST2 PF16716.5 PIK57017.1 - 0.055 14.0 155.9 1.7 9.3 1.1 18.6 18 0 0 18 18 18 0 Bone marrow stromal antigen 2 Rhamno_transf PF11316.8 PIK57017.1 - 0.15 11.4 19.4 15 4.9 0.1 8.3 9 0 0 9 9 9 0 Putative rhamnosyl transferase YjcZ PF13990.6 PIK57017.1 - 5.5 6.3 64.8 3.3 7.0 1.0 9.1 9 0 0 9 9 9 0 YjcZ-like protein Nitr_red_alph_N PF14710.6 PIK57017.1 - 6.4 7.3 14.0 1.1e+02 3.3 0.1 6.5 6 0 0 6 6 6 0 Respiratory nitrate reductase alpha N-terminal RNase_PH_C PF03725.15 PIK57018.1 - 0.61 10.2 2.6 0.94 9.6 0.4 2.2 1 1 1 2 2 2 0 3' exoribonuclease family, domain 2 Fungal_TACC PF12709.7 PIK57018.1 - 2.9 8.4 6.8 0.18 12.3 0.5 2.2 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Rad60-SLD PF11976.8 PIK57019.1 - 1.9e-20 72.4 0.8 2.8e-20 71.9 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 PIK57019.1 - 3.6e-13 49.1 0.5 4.7e-13 48.7 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family PEHE PF15275.6 PIK57020.1 - 3.3e-16 60.1 8.0 3.3e-16 60.1 8.0 2.4 2 1 0 2 2 2 2 PEHE domain RNA_pol_Rpb2_6 PF00562.28 PIK57021.1 - 2.5e-120 402.1 0.0 5.7e-120 401.0 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 PIK57021.1 - 1.3e-35 122.7 0.0 2.2e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 PIK57021.1 - 4.5e-27 94.0 0.0 8.4e-27 93.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 PIK57021.1 - 3.1e-18 65.5 0.0 7.7e-18 64.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 PIK57021.1 - 2.1e-10 40.8 0.1 5.4e-10 39.5 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 PIK57021.1 - 2.3e-08 33.9 0.0 5e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Pkinase PF00069.25 PIK57022.1 - 2.5e-69 233.6 0.0 3.2e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57022.1 - 1.4e-31 109.7 0.0 1.9e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK57022.1 - 0.00018 20.6 0.1 0.0012 17.8 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK57022.1 - 0.003 16.7 0.1 0.0047 16.0 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 PIK57022.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 PIK57022.1 - 0.049 13.5 0.2 0.065 13.1 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kelch_1 PF01344.25 PIK57023.1 - 1.6e-69 229.3 16.9 4.8e-13 48.5 1.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK57023.1 - 5.5e-42 140.7 5.1 1.4e-08 34.7 0.1 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 PIK57023.1 - 1.7e-34 118.0 0.4 3.4e-34 117.0 0.4 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 PIK57023.1 - 3.5e-31 107.7 1.6 6.2e-31 106.9 1.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 PIK57023.1 - 7.8e-29 99.4 9.4 0.00019 21.6 0.0 6.8 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK57023.1 - 8.4e-28 95.3 1.4 8.1e-05 22.4 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 PIK57023.1 - 2.5e-26 91.4 0.1 2.6e-05 24.1 0.0 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK57023.1 - 1.2e-09 37.9 12.5 0.062 13.3 1.0 6.7 6 1 1 7 7 7 3 Kelch motif VWD PF00094.25 PIK57024.1 - 3.2e-43 147.7 0.3 8.7e-25 87.8 0.7 2.4 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 PIK57024.1 - 8.7e-17 61.3 13.1 9.3e-11 42.0 3.6 3.7 3 0 0 3 3 3 2 C8 domain TIL PF01826.17 PIK57024.1 - 1.7e-08 34.6 16.0 1.7e-08 34.6 16.0 3.9 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain VWD PF00094.25 PIK57025.1 - 1.2e-32 113.4 0.9 3.9e-32 111.7 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 PIK57025.1 - 5.8e-13 49.1 5.7 5.8e-13 49.1 5.7 4.0 2 2 2 4 4 4 1 C8 domain TIL PF01826.17 PIK57025.1 - 1.2e-09 38.3 18.2 1.2e-09 38.3 18.2 4.9 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain ROF PF07073.12 PIK57026.1 - 0.0022 18.1 0.2 1 9.6 0.0 3.1 4 0 0 4 4 4 2 Modulator of Rho-dependent transcription termination (ROF) ROF PF07073.12 PIK57027.1 - 7.5e-07 29.2 0.0 1.8 8.8 0.0 4.1 4 0 0 4 4 4 3 Modulator of Rho-dependent transcription termination (ROF) Fve PF09259.11 PIK57027.1 - 0.0037 17.4 0.1 7.6 6.7 0.0 3.5 3 0 0 3 3 3 1 Fungal immunomodulatory protein Fve RinB PF06116.12 PIK57027.1 - 0.0051 16.9 1.2 40 4.4 0.0 3.6 3 0 0 3 3 3 0 Transcriptional activator RinB ACT_7 PF13840.6 PIK57027.1 - 0.008 15.9 1.3 40 4.1 0.2 4.1 3 1 0 3 3 3 0 ACT domain tRNA_edit PF04073.15 PIK57027.1 - 0.015 15.4 0.1 74 3.5 0.0 3.7 3 0 0 3 3 3 0 Aminoacyl-tRNA editing domain DUF3892 PF13031.6 PIK57027.1 - 0.052 14.2 0.5 1.2e+02 3.5 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3892) DUF4907 PF16250.5 PIK57027.1 - 0.066 13.1 1.0 1.1e+02 2.7 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4907) DUF4864 PF16156.5 PIK57027.1 - 0.41 11.4 6.0 1.4e+02 3.3 0.0 4.8 7 0 0 7 7 7 0 Domain of unknown function (DUF4864) Fe-S_assembly PF04384.13 PIK57027.1 - 3.7 8.2 6.2 2.2e+02 2.5 0.1 4.0 4 0 0 4 4 4 0 Iron-sulphur cluster assembly ROF PF07073.12 PIK57028.1 - 0.0004 20.5 0.1 0.61 10.3 0.0 2.7 3 0 0 3 3 3 2 Modulator of Rho-dependent transcription termination (ROF) Fve PF09259.11 PIK57028.1 - 0.023 14.8 0.1 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Fungal immunomodulatory protein Fve RinB PF06116.12 PIK57028.1 - 0.03 14.4 0.1 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Transcriptional activator RinB ACT_7 PF13840.6 PIK57028.1 - 0.048 13.5 0.1 17 5.3 0.0 2.7 2 0 0 2 2 2 0 ACT domain DUF3110 PF11360.8 PIK57029.1 - 0.0014 18.8 0.3 0.072 13.3 0.1 2.3 1 1 0 2 2 2 1 Protein of unknown function (DUF3110) PAD_M PF08527.10 PIK57029.1 - 0.058 13.0 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain Pannexin_like PF12534.8 PIK57029.1 - 0.23 10.5 1.3 0.31 10.1 1.3 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 SSP160 PF06933.11 PIK57029.1 - 0.75 7.9 11.7 1.1 7.3 11.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3110 PF11360.8 PIK57030.1 - 1.9e-16 60.0 20.1 36 4.7 0.0 17.7 22 0 0 22 22 22 0 Protein of unknown function (DUF3110) DUF1257 PF06868.11 PIK57030.1 - 1.7e-11 44.3 0.1 1.9e+02 2.4 0.0 10.9 11 0 0 11 11 11 0 Protein of unknown function (DUF1257) PAD_M PF08527.10 PIK57030.1 - 2.8e-11 43.3 9.9 18 4.9 0.1 9.6 10 0 0 10 10 10 0 Protein-arginine deiminase (PAD) middle domain VWA_N2 PF16164.5 PIK57030.1 - 2.6e-09 37.1 56.2 0.55 10.4 1.1 9.7 10 0 0 10 10 10 7 VWA N-terminal Uso1_p115_head PF04869.14 PIK57030.1 - 1.4e-05 24.4 22.5 17 4.4 0.1 10.2 11 0 0 11 11 11 0 Uso1 / p115 like vesicle tethering protein, head region PcfJ PF14284.6 PIK57030.1 - 0.0026 17.7 24.0 77 3.1 0.1 10.3 10 0 0 10 10 10 0 PcfJ-like protein DUF3247 PF11607.8 PIK57030.1 - 0.0035 17.6 26.5 1.2e+02 3.1 0.1 10.2 10 0 0 10 10 10 0 Protein of unknown function (DUF3247) DUF4592 PF15262.6 PIK57030.1 - 0.033 14.9 34.2 25 5.6 0.3 7.6 7 0 0 7 7 7 0 Domain of unknown function (DUF4592) PPDK_N PF01326.19 PIK57030.1 - 0.044 13.1 7.6 13 5.0 0.1 5.7 9 0 0 9 9 9 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain IFNGR1 PF07140.11 PIK57030.1 - 0.58 10.3 0.0 0.58 10.3 0.0 3.8 6 0 0 6 6 6 0 Interferon gamma receptor (IFNGR1) Tcp10_C PF07202.13 PIK57030.1 - 0.63 10.0 10.0 1.3e+02 2.4 0.0 6.3 7 0 0 7 7 7 0 T-complex protein 10 C-terminus YjeJ PF15922.5 PIK57030.1 - 1.1 8.4 17.9 2.4 7.3 0.1 7.8 9 0 0 9 9 9 0 YjeJ-like Synapsin_N PF10581.9 PIK57030.1 - 3.3 7.7 32.9 2.1e+02 2.0 0.1 10.6 11 0 0 11 11 11 0 Synapsin N-terminal DUF3110 PF11360.8 PIK57031.1 - 3e-05 24.1 0.3 4.2 7.6 0.0 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF3110) VWA_N2 PF16164.5 PIK57031.1 - 0.00085 19.4 5.2 0.053 13.7 1.1 2.4 2 0 0 2 2 2 2 VWA N-terminal PAD_M PF08527.10 PIK57031.1 - 0.0015 18.2 0.2 2 8.0 0.0 2.6 3 0 0 3 3 3 2 Protein-arginine deiminase (PAD) middle domain DUF3247 PF11607.8 PIK57031.1 - 0.034 14.4 0.5 14 6.0 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3247) Uso1_p115_head PF04869.14 PIK57031.1 - 0.034 13.3 0.2 7.8 5.5 0.0 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region DUF1583 PF07622.11 PIK57031.1 - 0.036 12.8 0.1 4 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1583) DUF585 PF04522.12 PIK57031.1 - 0.038 13.6 1.9 4.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF585) DUF1257 PF06868.11 PIK57031.1 - 0.11 12.7 0.0 30 4.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1257) PcfJ PF14284.6 PIK57031.1 - 0.15 12.0 1.3 14 5.5 0.6 2.8 2 1 1 3 3 3 0 PcfJ-like protein RAC_head PF16717.5 PIK57031.1 - 0.65 11.0 2.5 40 5.3 0.1 2.7 2 0 0 2 2 2 0 Ribosome-associated complex head domain DUF5105 PF17118.5 PIK57031.1 - 2.5 7.8 9.1 13 5.5 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5105) DUF3110 PF11360.8 PIK57032.1 - 0.033 14.4 0.1 2.1 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3110) PAD_M PF08527.10 PIK57032.1 - 0.089 12.5 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain Cys_knot PF00007.22 PIK57033.1 - 1.2e-07 32.0 17.3 1.2e-07 32.0 17.3 3.0 1 1 1 3 3 3 1 Cystine-knot domain DAN PF03045.15 PIK57033.1 - 0.00082 19.4 16.9 0.004 17.2 16.9 2.2 1 1 0 1 1 1 1 DAN domain Sclerostin PF05463.11 PIK57033.1 - 0.0078 15.9 0.4 0.0078 15.9 0.4 2.1 2 0 0 2 2 2 1 Sclerostin (SOST) DUF1891 PF09004.10 PIK57034.1 - 3.6e-16 58.5 0.7 6.3e-16 57.7 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) RVT_1 PF00078.27 PIK57034.1 - 3.5e-05 23.4 0.0 5.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) REJ PF02010.15 PIK57036.1 - 1.1e-33 116.7 7.6 1.1e-33 116.7 7.6 2.5 2 1 0 3 3 3 2 REJ domain GPS PF01825.21 PIK57036.1 - 0.00018 21.9 0.3 0.0006 20.3 0.3 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TMEM52 PF14979.6 PIK57036.1 - 0.023 14.6 0.1 0.023 14.6 0.1 2.3 2 0 0 2 2 2 0 Transmembrane 52 Adeno_E3_CR2 PF02439.15 PIK57036.1 - 2.4 8.0 4.5 6.5 6.6 4.5 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SPRY PF00622.28 PIK57037.1 - 6.2e-09 36.0 0.2 3.3e-06 27.2 0.0 2.8 3 1 0 3 3 3 2 SPRY domain Ras PF00071.22 PIK57038.1 - 8.7e-34 116.5 0.0 1.1e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57038.1 - 2.3e-21 76.2 0.0 3.7e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57038.1 - 4.4e-10 39.3 0.0 5.4e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK57038.1 - 3.3e-05 23.5 0.0 0.001 18.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK57038.1 - 0.003 17.6 0.0 0.0063 16.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 PIK57038.1 - 0.024 14.4 0.1 0.036 13.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK57038.1 - 0.043 13.7 0.0 5.7 6.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 PIK57038.1 - 0.094 12.2 0.1 0.18 11.3 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 PIK57038.1 - 0.18 12.1 0.0 0.28 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF3337 PF11816.8 PIK57039.1 - 1.3e-41 142.4 0.0 2.1e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 PIK57039.1 - 1.4e-23 82.7 5.3 0.00017 22.3 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57039.1 - 5.7e-05 23.3 1.1 1.8 8.9 0.1 4.6 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RAWUL PF16207.5 PIK57039.1 - 0.00065 20.3 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like p450 PF00067.22 PIK57040.1 - 1.9e-91 307.1 0.0 2.1e-91 307.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tma16 PF11176.8 PIK57040.1 - 0.091 12.6 0.2 0.14 12.1 0.2 1.2 1 0 0 1 1 1 0 Translation machinery-associated protein 16 BAR_3 PF16746.5 PIK57041.1 - 6.2e-21 75.2 6.0 1.5e-20 73.9 6.0 1.6 1 1 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 PIK57041.1 - 8.1e-09 35.9 4.6 8.2e-09 35.9 0.2 2.5 2 1 1 3 3 3 1 PH domain BAR PF03114.18 PIK57041.1 - 2.6e-05 24.0 2.1 4.8e-05 23.1 2.1 1.4 1 0 0 1 1 1 1 BAR domain PH_9 PF15410.6 PIK57041.1 - 0.0071 16.7 0.4 0.092 13.1 0.1 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 PIK57041.1 - 0.0082 16.2 0.7 0.13 12.4 0.0 2.5 2 0 0 2 2 2 1 PH domain IMD PF08397.11 PIK57041.1 - 0.018 14.4 0.3 0.018 14.4 0.3 2.4 2 1 1 3 3 3 0 IRSp53/MIM homology domain DUF4404 PF14357.6 PIK57041.1 - 0.069 13.8 3.4 0.07 13.8 0.4 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4404) CCDC74_C PF14917.6 PIK57041.1 - 0.094 13.2 0.4 0.27 11.8 0.4 1.8 1 0 0 1 1 1 0 Coiled coil protein 74, C terminal Syntaxin_2 PF14523.6 PIK57041.1 - 0.12 12.7 3.3 6.6 7.2 0.6 2.5 2 0 0 2 2 2 0 Syntaxin-like protein DUF4522 PF15022.6 PIK57041.1 - 0.48 10.7 4.3 7.9 6.8 0.1 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF4522) ArfGap PF01412.18 PIK57042.1 - 1.8e-32 111.9 0.0 4.3e-32 110.6 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 PIK57042.1 - 1.2e-14 54.7 1.0 3.5e-10 40.3 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SH3_1 PF00018.28 PIK57042.1 - 1.1e-12 47.3 0.2 2.1e-12 46.4 0.2 1.5 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.6 PIK57042.1 - 8.8e-11 42.1 0.5 1.8e-06 28.4 0.1 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) SH3_2 PF07653.17 PIK57042.1 - 5.8e-10 38.7 0.1 1.2e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.6 PIK57042.1 - 1.1e-09 38.3 0.2 3.1e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK57042.1 - 1.2e-09 37.6 0.3 7.2e-06 26.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat SH3_9 PF14604.6 PIK57042.1 - 1.7e-09 37.3 0.2 1.7e-09 37.3 0.2 1.8 2 0 0 2 2 2 1 Variant SH3 domain Ank PF00023.30 PIK57042.1 - 2.2e-09 37.3 1.9 1.6e-06 28.3 0.3 3.3 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.25 PIK57043.1 - 3.9e-10 39.5 0.0 4.7e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57043.1 - 0.0039 16.5 0.0 0.0043 16.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase 5_nucleotid PF05761.14 PIK57043.1 - 0.011 14.7 0.0 0.012 14.5 0.0 1.0 1 0 0 1 1 1 0 5' nucleotidase family DCP2 PF05026.13 PIK57043.1 - 0.1 12.9 0.6 0.34 11.3 0.6 1.8 1 1 1 2 2 2 0 Dcp2, box A domain GTP_EFTU PF00009.27 PIK57044.1 - 3.7e-54 183.2 0.0 6.1e-54 182.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 PIK57044.1 - 7.1e-43 145.5 0.2 2.9e-42 143.5 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 PIK57044.1 - 2.2e-16 60.0 1.5 3.6e-16 59.3 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 PIK57044.1 - 0.00014 21.9 0.2 0.0038 17.3 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 PIK57044.1 - 0.01 15.7 0.3 0.043 13.7 0.3 2.0 1 0 0 1 1 1 0 Elongation factor Tu domain 4 zinc_ribbon_12 PF11331.8 PIK57044.1 - 0.058 13.2 0.6 0.12 12.2 0.6 1.5 1 0 0 1 1 1 0 Probable zinc-ribbon domain Abhydrolase_9_N PF15420.6 PIK57045.1 - 0.00021 21.3 1.8 0.00027 21.0 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus YlaC PF10777.9 PIK57045.1 - 0.017 14.9 0.4 0.017 14.9 0.4 1.6 2 0 0 2 2 2 0 Inner membrane protein YlaC EamA PF00892.20 PIK57045.1 - 1 9.6 12.9 3.8 7.7 12.9 1.8 1 1 0 1 1 1 0 EamA-like transporter family CclA_1 PF16942.5 PIK57046.1 - 0.39 11.0 2.5 10 6.4 0.2 2.3 1 1 1 2 2 2 0 Putative cyclic bacteriocin DUF3824 PF12868.7 PIK57047.1 - 0.069 13.8 0.6 0.069 13.8 0.6 1.6 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) MFMR_assoc PF16596.5 PIK57047.1 - 1.3 9.5 11.4 0.12 12.8 6.0 1.9 1 1 1 2 2 2 0 Disordered region downstream of MFMR GAPT PF11770.8 PIK57048.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) TMEM51 PF15345.6 PIK57048.1 - 0.058 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 PIK57048.1 - 0.074 12.7 0.5 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 FAM176 family DUF4514 PF14986.6 PIK57048.1 - 0.096 12.7 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) ECH_1 PF00378.20 PIK57049.1 - 7e-54 182.8 0.0 8.6e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK57049.1 - 4.7e-32 111.8 0.1 1e-31 110.7 0.1 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase zf-C2H2 PF00096.26 PIK57050.1 - 1.9e-13 50.0 37.7 6.5e-05 23.2 2.1 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK57050.1 - 7.5e-10 38.8 8.6 6.9e-07 29.4 1.0 5.5 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK57050.1 - 3.5e-05 24.3 32.4 0.054 14.3 0.7 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK57050.1 - 0.0039 16.9 1.7 0.0039 16.9 1.7 5.2 5 0 0 5 5 5 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 PIK57050.1 - 0.23 11.8 26.8 1.6 9.1 1.5 4.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 PIK57051.1 - 2.3e-07 30.9 21.1 0.01 16.3 1.9 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK57051.1 - 0.00015 22.3 17.5 0.071 14.0 1.4 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 PIK57051.1 - 0.002 18.4 7.3 0.89 9.9 3.9 2.5 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 PIK57051.1 - 0.0088 16.3 9.4 0.9 9.9 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding TFIIS_C PF01096.18 PIK57051.1 - 0.2 11.5 5.6 0.58 10.1 2.3 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 PIK57051.1 - 1.6 8.7 5.3 31 4.7 0.0 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2H2_6 PF13912.6 PIK57051.1 - 4.3 7.5 12.4 0.2 11.7 1.7 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK57051.1 - 4.8 7.0 11.1 3.2 7.6 0.0 3.5 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-met PF12874.7 PIK57051.1 - 6 7.4 14.5 2 8.9 0.7 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF4653 PF15546.6 PIK57052.1 - 0.013 15.1 0.6 0.013 15.1 0.6 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4653) YceD PF02620.17 PIK57052.1 - 0.2 11.8 1.7 0.23 11.6 0.4 1.7 2 0 0 2 2 2 0 Large ribosomal RNA subunit accumulation protein YceD CUB PF00431.20 PIK57053.1 - 2.5e-31 108.3 0.0 1.2e-17 64.2 0.0 3.0 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 PIK57053.1 - 2.9e-07 30.6 2.8 6.3e-07 29.5 2.8 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A LAGLIDADG_3 PF14528.6 PIK57053.1 - 0.1 12.9 0.1 13 6.2 0.0 2.3 2 0 0 2 2 2 0 LAGLIDADG-like domain Trypsin PF00089.26 PIK57054.1 - 5.8e-15 55.7 0.0 6.1e-15 55.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK57054.1 - 0.0074 16.7 0.0 0.0093 16.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) NACHT PF05729.12 PIK57055.1 - 0.0006 19.8 0.0 0.11 12.3 0.0 2.6 1 1 1 2 2 2 2 NACHT domain NACHT PF05729.12 PIK57057.1 - 2.3e-06 27.6 0.0 3.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK57058.1 - 0.056 13.8 0.0 0.067 13.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Thyroglobulin_1 PF00086.18 PIK57059.1 - 3.9e-15 55.3 4.8 3.9e-15 55.3 4.8 2.1 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.15 PIK57059.1 - 1.7e-09 37.6 6.5 1.7e-09 37.6 6.5 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK57059.1 - 0.00044 20.2 5.5 0.00044 20.2 5.5 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain DUF1129 PF06570.11 PIK57060.1 - 0.15 11.5 6.0 0.085 12.3 3.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Fzo_mitofusin PF04799.13 PIK57060.1 - 0.37 10.3 2.7 0.61 9.6 2.7 1.3 1 0 0 1 1 1 0 fzo-like conserved region KleE PF17394.2 PIK57060.1 - 0.43 10.8 6.7 0.54 10.5 0.9 2.5 1 1 1 2 2 2 0 Uncharacterized KleE stable inheritance protein PAS_9 PF13426.7 PIK57061.1 - 4.6e-11 42.9 0.0 7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 PIK57061.1 - 0.012 15.8 0.0 0.026 14.8 0.0 1.6 2 0 0 2 2 2 0 PAS fold PAS PF00989.25 PIK57061.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold PAS_3 PF08447.12 PIK57061.1 - 0.086 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold Ion_trans PF00520.31 PIK57062.1 - 1.5e-18 66.9 2.2 1.6e-18 66.8 2.2 1.0 1 0 0 1 1 1 1 Ion transport protein DUF267 PF03268.14 PIK57062.1 - 0.0063 15.4 0.1 0.0082 15.1 0.1 1.2 1 0 0 1 1 1 1 Caenorhabditis protein of unknown function, DUF267 SafA PF17073.5 PIK57062.1 - 0.067 13.1 0.7 0.33 10.9 0.0 2.3 1 1 1 2 2 2 0 Two-component-system connector protein cNMP_binding PF00027.29 PIK57063.1 - 1e-08 35.1 0.0 1.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 PIK57063.1 - 0.00067 19.3 0.1 0.0012 18.5 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 PIK57063.1 - 0.068 12.9 0.0 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Rotavirus_VP7 PF05868.11 PIK57064.1 - 0.044 13.2 0.0 5.1 6.4 0.0 2.1 2 0 0 2 2 2 0 Rotavirus major outer capsid protein VP7 Harakiri PF15196.6 PIK57064.1 - 0.047 14.1 0.0 10 6.7 0.0 2.3 2 0 0 2 2 2 0 Activator of apoptosis harakiri DUF5329 PF17263.2 PIK57064.1 - 0.18 12.0 0.1 22 5.3 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5329) ADH_N PF08240.12 PIK57064.1 - 0.24 11.3 7.8 1.4 8.8 0.7 2.8 2 1 1 3 3 3 0 Alcohol dehydrogenase GroES-like domain zf-CCCH PF00642.24 PIK57065.1 - 2.7e-24 84.5 13.8 2.4e-12 46.4 3.6 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK57065.1 - 5.5e-13 48.5 14.1 2.1e-07 30.7 4.2 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 PIK57065.1 - 1.3e-10 40.8 13.2 3.1e-07 30.0 2.4 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 PIK57065.1 - 0.00097 19.8 9.1 0.21 12.3 1.2 2.4 1 1 1 2 2 2 2 Torus domain Tis11B_N PF04553.12 PIK57065.1 - 0.012 16.1 0.4 0.026 15.1 0.4 1.7 1 0 0 1 1 1 0 Tis11B like protein, N terminus zf-CCCH_2 PF14608.6 PIK57065.1 - 0.044 14.3 21.7 0.046 14.2 2.5 3.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger oligo_HPY PF08352.12 PIK57065.1 - 0.86 10.2 8.7 3.4 8.3 0.6 2.5 1 1 1 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Pkinase PF00069.25 PIK57066.1 - 1.1e-31 110.2 0.0 2.3e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57066.1 - 4.9e-24 85.0 0.0 1.2e-23 83.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 PIK57066.1 - 0.029 13.4 0.0 0.055 12.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 PIK57066.1 - 0.036 13.7 0.0 4 7.0 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PEGA PF08308.11 PIK57067.1 - 8.5e-06 25.6 0.9 27 4.7 0.0 6.1 6 0 0 6 6 6 1 PEGA domain GXWXG PF14231.6 PIK57067.1 - 0.0011 19.0 0.0 1.9e+02 2.2 0.0 5.8 6 0 0 6 6 6 0 GXWXG protein MULE PF10551.9 PIK57067.1 - 0.0036 17.7 0.0 0.009 16.4 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain SWIM PF04434.17 PIK57067.1 - 0.099 12.3 4.0 0.26 11.0 4.0 1.6 1 0 0 1 1 1 0 SWIM zinc finger PRA-CH PF01502.18 PIK57067.1 - 1.9 8.3 9.3 1.8e+02 2.0 0.1 5.5 2 2 4 6 6 6 0 Phosphoribosyl-AMP cyclohydrolase DAP_B PF07930.12 PIK57068.1 - 0.083 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase, domain B Rad51 PF08423.11 PIK57069.1 - 1.1e-22 80.6 0.0 1.5e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 PIK57069.1 - 1.4e-07 31.1 1.0 2.1e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 PIK57069.1 - 2.7e-07 30.4 0.0 3.8e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 PIK57069.1 - 2.9e-05 24.6 0.0 0.00013 22.5 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain ABC_tran PF00005.27 PIK57069.1 - 0.014 15.9 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RNA_pol_A_CTD PF03118.15 PIK57069.1 - 0.032 14.0 0.1 0.05 13.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF3160 PF11369.8 PIK57069.1 - 0.28 9.6 4.0 1.6 7.1 0.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3160) ECH_1 PF00378.20 PIK57070.1 - 1.2e-38 132.9 0.2 1.8e-38 132.3 0.2 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK57070.1 - 1.1e-07 31.7 0.2 1.7e-07 31.0 0.2 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK57071.1 - 6.9e-32 110.7 0.0 9e-32 110.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK57072.1 - 1.2e-20 73.9 0.0 1.9e-20 73.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase rve PF00665.26 PIK57073.1 - 9.1e-13 48.4 0.0 1.5e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK57073.1 - 0.003 17.3 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK57074.1 - 4.3e-38 129.4 0.0 8.4e-38 128.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57074.1 - 8.4e-38 128.9 0.0 1.5e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK57074.1 - 1.5e-07 31.2 0.2 5e-05 22.9 0.1 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK57076.1 - 9.3e-26 90.7 0.0 3e-25 89.0 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_2 PF07974.13 PIK57077.1 - 0.00043 20.6 5.4 0.00043 20.6 5.4 6.2 5 2 0 5 5 5 2 EGF-like domain TMEM154 PF15102.6 PIK57077.1 - 0.014 15.3 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF2207 PF09972.9 PIK57077.1 - 0.17 10.6 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Laminin_EGF PF00053.24 PIK57077.1 - 0.99 9.6 45.7 0.067 13.3 12.8 3.7 2 1 2 4 4 4 0 Laminin EGF domain SNARE PF05739.19 PIK57078.1 - 1.3e-08 34.6 0.1 3.1e-08 33.5 0.1 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 PIK57078.1 - 1.4e-07 30.5 1.0 1.4e-07 30.5 1.0 2.5 3 0 0 3 3 3 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 PIK57078.1 - 0.0022 17.7 18.8 0.015 15.0 2.4 2.6 2 1 0 2 2 2 2 Syntaxin DUF948 PF06103.11 PIK57078.1 - 0.0055 16.9 7.9 0.16 12.2 0.2 3.0 2 1 0 2 2 2 2 Bacterial protein of unknown function (DUF948) SKA1 PF07160.12 PIK57078.1 - 0.0066 16.3 14.2 0.14 11.9 4.8 2.3 2 1 0 2 2 2 2 Spindle and kinetochore-associated protein 1 UPF0242 PF06785.11 PIK57078.1 - 0.012 15.7 18.4 0.052 13.7 6.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MCPsignal PF00015.21 PIK57078.1 - 0.032 14.0 0.8 0.032 14.0 0.8 2.3 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Vac_Fusion PF02346.16 PIK57078.1 - 0.083 12.5 1.1 0.78 9.4 0.1 3.0 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF5063 PF16702.5 PIK57078.1 - 0.087 13.2 2.5 2.7 8.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5063) TSC22 PF01166.18 PIK57078.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family Syntaxin-18_N PF10496.9 PIK57078.1 - 0.22 11.8 6.3 10 6.4 0.2 4.0 4 0 0 4 4 4 0 SNARE-complex protein Syntaxin-18 N-terminus NPV_P10 PF05531.12 PIK57078.1 - 0.25 11.8 11.0 13 6.3 6.0 3.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Peptidase_C101 PF16218.5 PIK57078.1 - 0.27 10.4 7.1 0.033 13.5 2.7 1.7 2 0 0 2 2 2 0 Peptidase family C101 Baculo_PEP_C PF04513.12 PIK57078.1 - 0.76 9.8 13.0 4.5 7.3 7.0 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KASH_CCD PF14662.6 PIK57078.1 - 1 9.1 19.3 0.35 10.7 1.9 2.8 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH LPP PF04728.13 PIK57078.1 - 1 9.8 9.8 3.4 8.1 0.9 3.5 2 1 1 3 3 3 0 Lipoprotein leucine-zipper HrpB7 PF09486.10 PIK57078.1 - 2.4 8.5 6.0 1.1 9.7 1.2 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) IZUMO PF15005.6 PIK57078.1 - 3 8.4 7.7 2.6 8.5 0.1 2.9 2 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated DUF1664 PF07889.12 PIK57078.1 - 4 7.5 13.6 5.3 7.1 2.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 PIK57078.1 - 4.9 7.3 12.0 3.3 7.9 2.2 2.5 2 0 0 2 2 2 0 Tropomyosin like SlyX PF04102.12 PIK57078.1 - 6.4 7.5 15.2 6.2 7.5 2.2 3.2 2 1 1 3 3 3 0 SlyX BLOC1_2 PF10046.9 PIK57078.1 - 7 7.0 10.4 4.4 7.7 0.8 3.2 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 PIK57078.1 - 7.1 7.2 19.0 0.27 11.7 2.8 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Wbp11 PF09429.10 PIK57078.1 - 7.3 7.1 8.9 1.9 8.9 0.7 3.4 2 1 2 4 4 4 0 WW domain binding protein 11 Met_synt_B12 PF02965.17 PIK57079.1 - 4.4e-122 406.8 0.0 8e-122 405.9 0.0 1.5 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.22 PIK57079.1 - 1.6e-48 165.5 0.9 4.6e-47 160.7 0.9 2.7 1 1 0 1 1 1 1 Pterin binding enzyme S-methyl_trans PF02574.16 PIK57079.1 - 2.4e-39 135.8 0.0 1.8e-23 83.8 0.0 2.6 1 1 1 2 2 2 2 Homocysteine S-methyltransferase B12-binding_2 PF02607.17 PIK57079.1 - 1.6e-23 82.9 0.1 2.9e-22 78.9 0.0 2.9 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 PIK57079.1 - 1.2e-19 70.5 0.2 4.3e-19 68.7 0.2 2.0 1 0 0 1 1 1 1 B12 binding domain CdhD PF03599.16 PIK57079.1 - 0.12 11.1 0.1 0.23 10.1 0.1 1.4 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Ferritin PF00210.24 PIK57079.1 - 0.13 12.1 0.4 46 3.9 0.2 3.4 3 0 0 3 3 3 0 Ferritin-like domain SMK-1 PF04802.15 PIK57080.1 - 6.1e-69 231.7 10.1 6.1e-69 231.7 10.1 2.0 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 SNAPc19 PF15497.6 PIK57080.1 - 1.4 9.4 6.5 6.2 7.4 6.5 2.2 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 DUF3231 PF11553.8 PIK57081.1 - 0.07 12.7 1.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) UIM PF02809.20 PIK57081.1 - 0.15 12.0 8.9 14 5.8 0.0 4.3 3 0 0 3 3 3 0 Ubiquitin interaction motif HOOK PF05622.12 PIK57082.1 - 4.3e-20 71.5 25.4 2.2e-19 69.1 25.4 1.8 1 1 0 1 1 1 1 HOOK protein THOC7 PF05615.13 PIK57082.1 - 0.001 19.4 11.5 0.0024 18.1 11.4 1.8 1 1 0 1 1 1 1 Tho complex subunit 7 ERM PF00769.19 PIK57082.1 - 0.02 14.7 15.5 0.034 14.0 15.5 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family UPF0242 PF06785.11 PIK57082.1 - 0.031 14.4 15.6 0.057 13.5 15.6 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 PIK57082.1 - 0.05 14.1 16.8 0.064 13.8 14.7 2.2 2 1 0 2 2 1 0 Apg6 coiled-coil region HAUS6_N PF14661.6 PIK57082.1 - 0.053 13.1 5.3 0.11 12.1 5.3 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Seryl_tRNA_N PF02403.22 PIK57082.1 - 0.22 11.8 12.5 0.48 10.7 2.6 3.4 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 PIK57082.1 - 0.58 9.0 14.6 0.98 8.2 14.4 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein JAB PF01398.21 PIK57082.1 - 2.6 8.0 5.4 50 3.9 0.0 2.7 2 1 0 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_S30AE PF02482.19 PIK57082.1 - 4.1 8.3 8.1 7.4 7.4 6.5 2.1 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF1764 PF08576.10 PIK57082.1 - 5.1 8.1 5.5 11 7.0 5.5 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4315 PF14193.6 PIK57082.1 - 6.4 6.9 13.9 16 5.6 0.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4315) BLOC1_2 PF10046.9 PIK57082.1 - 9.3 6.6 15.5 5.6 7.3 4.0 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Proteasome PF00227.26 PIK57084.1 - 5.8e-33 114.0 1.8 2.2e-21 76.2 0.0 2.4 2 1 1 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.9 PIK57084.1 - 1e-12 47.4 0.1 1.9e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CDP-OH_P_transf PF01066.21 PIK57085.1 - 2.9e-08 34.3 0.0 2.9e-08 34.3 0.0 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase EMP24_GP25L PF01105.24 PIK57086.1 - 8.1e-31 107.4 0.0 1.1e-30 106.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Xan_ur_permease PF00860.20 PIK57086.1 - 0.0042 15.8 0.0 0.0059 15.4 0.0 1.1 1 0 0 1 1 1 1 Permease family RCC1 PF00415.18 PIK57088.1 - 4.3e-17 62.5 0.1 1.8e-07 31.7 0.0 2.0 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK57088.1 - 5.2e-05 22.9 0.0 8.3e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 PIK57089.1 - 4.5e-30 104.0 0.1 3.2e-07 30.9 0.0 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK57089.1 - 1.1e-17 63.3 4.0 8.7e-07 28.6 0.0 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Jnk-SapK_ap_N PF09744.9 PIK57089.1 - 0.023 14.9 0.8 0.036 14.3 0.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Msap1 PF17077.5 PIK57089.1 - 0.042 13.0 0.4 0.059 12.5 0.4 1.2 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 PP2C PF00481.21 PIK57089.1 - 0.044 13.4 0.6 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein phosphatase 2C Csm1_N PF18504.1 PIK57089.1 - 0.084 13.2 0.5 0.21 12.0 0.5 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain bZIP_1 PF00170.21 PIK57089.1 - 0.1 12.7 1.5 0.19 11.9 1.5 1.4 1 0 0 1 1 1 0 bZIP transcription factor RCC1 PF00415.18 PIK57090.1 - 1.3e-48 163.3 21.7 2.1e-10 41.0 0.1 8.3 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 PIK57090.1 - 1.6e-44 152.3 0.1 2.5e-44 151.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57090.1 - 2.6e-31 108.9 0.1 4.4e-31 108.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.6 PIK57090.1 - 9.6e-28 95.4 12.2 7.2e-06 25.7 0.0 7.2 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.6 PIK57090.1 - 2.6e-05 23.7 0.0 4.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like MTBP_N PF14918.6 PIK57091.1 - 7.3e-21 74.8 0.1 1.2e-20 74.1 0.1 1.2 1 0 0 1 1 1 1 MDM2-binding MTBP_C PF14920.6 PIK57092.1 - 2.1e-29 103.1 19.6 4.5e-19 69.2 4.1 3.0 2 1 1 3 3 3 2 MDM2-binding MTBP_mid PF14919.6 PIK57092.1 - 0.016 14.5 0.0 0.034 13.3 0.0 1.5 1 0 0 1 1 1 0 MDM2-binding SIL1 PF16782.5 PIK57092.1 - 0.02 14.2 0.5 0.035 13.3 0.5 1.3 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 Caveolin PF01146.17 PIK57093.1 - 2.4e-21 76.1 0.1 3.3e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Caveolin Caveolin PF01146.17 PIK57094.1 - 6e-21 74.8 0.3 8.5e-21 74.3 0.3 1.1 1 0 0 1 1 1 1 Caveolin Tho2 PF11262.8 PIK57095.1 - 3.3e-71 240.0 0.2 3.3e-71 240.0 0.2 1.6 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Sulfotransfer_1 PF00685.27 PIK57096.1 - 6e-25 88.2 0.1 7.9e-25 87.8 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK57096.1 - 5e-11 43.4 0.0 5e-10 40.1 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK57097.1 - 1.7e-22 80.2 0.0 2.6e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK57097.1 - 3e-12 47.4 0.0 2.3e-11 44.5 0.0 2.2 1 1 0 1 1 1 1 Sulfotransferase family TGFb_propeptide PF00688.18 PIK57098.1 - 3.1e-42 145.0 0.0 4.5e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 PIK57098.1 - 4e-34 117.7 0.6 8.2e-34 116.7 0.6 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Thioredoxin PF00085.20 PIK57099.1 - 3.5e-12 46.2 0.0 3.7e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin ALO PF04030.14 PIK57100.1 - 6.4e-80 268.7 1.3 7.5e-80 268.5 1.3 1.0 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 PIK57101.1 - 2.2e-06 27.5 0.0 4.1e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain MqsR_toxin PF15723.5 PIK57101.1 - 0.055 13.8 0.3 0.074 13.4 0.3 1.2 1 0 0 1 1 1 0 Motility quorum-sensing regulator, toxin of MqsA BAF250_C PF12031.8 PIK57101.1 - 0.07 12.4 0.2 0.097 11.9 0.2 1.1 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa Flg_new PF09479.10 PIK57101.1 - 0.077 13.2 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) MFS_1 PF07690.16 PIK57102.1 - 3e-42 144.8 46.0 3.2e-24 85.5 19.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK57102.1 - 1.5e-12 47.1 22.0 4e-08 32.5 0.6 4.1 3 1 0 4 4 4 4 MFS_1 like family UPF0060 PF02694.15 PIK57102.1 - 0.37 11.0 6.0 0.64 10.3 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family MFS_1 PF07690.16 PIK57103.1 - 3.4e-30 105.2 44.9 5.7e-30 104.4 44.9 1.2 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK57103.1 - 6.1e-08 31.9 19.6 9e-05 21.5 1.3 3.3 2 2 1 3 3 3 3 MFS_1 like family UPF0060 PF02694.15 PIK57103.1 - 0.00077 19.7 1.7 0.64 10.3 0.1 2.9 2 0 0 2 2 2 2 Uncharacterised BCR, YnfA/UPF0060 family MerC PF03203.14 PIK57103.1 - 9.1 6.8 14.0 1.4 9.4 1.6 3.4 2 2 1 3 3 3 0 MerC mercury resistance protein MFS_1 PF07690.16 PIK57104.1 - 0.00011 21.2 0.0 0.00012 21.1 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 PIK57104.1 - 0.11 10.7 0.0 0.11 10.7 0.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Atg14 PF10186.9 PIK57105.1 - 0.028 13.5 0.5 0.054 12.6 0.5 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 7tm_1 PF00001.21 PIK57106.1 - 6e-16 58.6 15.4 5.6e-15 55.4 15.4 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK57106.1 - 2.8e-09 37.0 16.1 2.8e-09 37.0 16.1 2.4 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx RRM_1 PF00076.22 PIK57108.1 - 7.7e-15 54.5 0.0 1.1e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK57108.1 - 0.00031 20.8 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Trypsin PF00089.26 PIK57110.1 - 1.6e-46 158.9 0.0 2.5e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin Fz PF01392.22 PIK57110.1 - 3.1e-18 66.4 3.1 3.1e-18 66.4 3.1 1.9 2 1 0 2 2 2 1 Fz domain Ldl_recept_a PF00057.18 PIK57110.1 - 4e-06 26.9 5.3 4e-06 26.9 5.3 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 PIK57110.1 - 9.5e-06 26.0 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK57110.1 - 0.00035 21.5 0.0 0.00071 20.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Glypican PF01153.19 PIK57110.1 - 0.0085 15.0 0.4 0.026 13.4 0.4 1.7 2 0 0 2 2 2 1 Glypican CUB PF00431.20 PIK57111.1 - 7.2e-66 219.4 2.2 6e-14 52.3 0.0 7.3 6 1 0 6 6 6 6 CUB domain Ldl_recept_a PF00057.18 PIK57111.1 - 3e-40 136.1 170.2 1.5e-07 31.5 7.1 12.3 11 1 1 12 12 12 11 Low-density lipoprotein receptor domain class A HYR PF02494.16 PIK57111.1 - 2.2e-14 53.5 0.1 5.5e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 HYR domain Trypsin PF00089.26 PIK57111.1 - 5e-12 46.1 0.2 5e-12 46.1 0.2 2.5 3 0 0 3 3 3 1 Trypsin SEA PF01390.20 PIK57111.1 - 5.8e-07 29.6 1.0 1.2e-06 28.5 1.0 1.5 1 0 0 1 1 1 1 SEA domain NigD_N PF12667.7 PIK57111.1 - 0.37 10.9 1.9 18 5.5 0.1 3.1 3 0 0 3 3 3 0 NigD-like N-terminal OB domain HYR PF02494.16 PIK57112.1 - 9.1e-56 186.1 12.8 2.6e-20 72.5 0.2 3.4 3 0 0 3 3 3 3 HYR domain SEA PF01390.20 PIK57112.1 - 3.6e-15 55.9 0.3 8.3e-15 54.8 0.3 1.7 1 0 0 1 1 1 1 SEA domain Reeler PF02014.16 PIK57112.1 - 0.096 13.4 0.1 7.2 7.4 0.0 2.7 1 1 1 2 2 2 0 Reeler domain HATPase_c_3 PF13589.6 PIK57113.1 - 3.7e-14 52.7 0.0 8.8e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 PIK57113.1 - 0.00023 21.6 0.0 0.0013 19.3 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 PIK57113.1 - 0.053 13.5 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Sec1 PF00995.23 PIK57114.1 - 5.6e-71 240.5 0.5 6.3e-71 240.3 0.5 1.0 1 0 0 1 1 1 1 Sec1 family TNF PF00229.18 PIK57114.1 - 0.012 15.5 0.0 0.026 14.5 0.0 1.7 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family Aldose_epim PF01263.20 PIK57115.1 - 3.1e-16 59.6 0.7 4.5e-10 39.3 0.0 2.0 1 1 1 2 2 2 2 Aldose 1-epimerase Integrin_alpha2 PF08441.12 PIK57115.1 - 0.041 12.8 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 Integrin alpha PHR PF08005.12 PIK57116.1 - 1.4e-47 162.2 0.1 2.3e-47 161.4 0.1 1.4 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 PIK57116.1 - 1.5e-26 92.8 0.1 2e-24 85.9 0.0 2.5 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 PIK57116.1 - 1.2e-11 44.6 1.3 2.1e-10 40.6 0.5 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF4082 PF13313.6 PIK57116.1 - 0.023 14.7 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) Pkinase_Tyr PF07714.17 PIK57117.1 - 1e-67 228.2 0.0 7.9e-67 225.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK57117.1 - 1.4e-29 103.3 0.0 2.7e-29 102.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain tRNA_SAD PF07973.14 PIK57117.1 - 0.099 12.8 0.3 0.22 11.7 0.3 1.6 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain XPA_C PF05181.12 PIK57118.1 - 9.7e-25 86.3 0.6 2.1e-24 85.2 0.6 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 PIK57118.1 - 8.3e-11 41.7 8.4 8.3e-11 41.7 8.4 2.0 2 0 0 2 2 2 1 XPA protein N-terminal zf-C4pol PF14260.6 PIK57118.1 - 0.088 13.3 0.4 0.088 13.3 0.4 2.6 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Zn-ribbon_8 PF09723.10 PIK57118.1 - 3.2 7.9 7.9 2.2 8.4 1.6 2.4 2 0 0 2 2 2 0 Zinc ribbon domain DUF2353 PF09789.9 PIK57119.1 - 0.0021 17.4 8.6 0.0021 17.4 8.6 8.0 2 2 6 8 8 8 2 Uncharacterized coiled-coil protein (DUF2353) Surfac_D-trimer PF09006.11 PIK57119.1 - 3.4 7.6 4.8 23 5.0 0.0 3.9 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation P53_C PF11619.8 PIK57120.1 - 0.52 10.4 3.2 1.4 9.1 0.2 3.0 3 0 0 3 3 3 0 Transcription factor P53 - C terminal domain TMF_TATA_bd PF12325.8 PIK57120.1 - 0.59 10.4 33.0 1.9 8.8 4.1 4.3 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.12 PIK57120.1 - 1.2 7.6 16.6 0.48 8.9 13.0 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family GAS PF13851.6 PIK57120.1 - 1.6 8.0 34.2 0.81 9.0 13.4 3.0 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding GPS2_interact PF15784.5 PIK57120.1 - 3.8 8.0 13.0 29 5.2 0.2 3.1 2 1 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain DivIC PF04977.15 PIK57120.1 - 9.6 6.1 26.0 5.6 6.8 6.9 4.9 3 2 2 5 5 5 0 Septum formation initiator DUF3372 PF11852.8 PIK57121.1 - 0.0046 16.4 0.1 0.025 14.1 0.1 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3372) TMEM223 PF14640.6 PIK57122.1 - 0.00023 21.4 0.1 0.00028 21.1 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 ubiquitin PF00240.23 PIK57123.1 - 2.4e-07 30.4 0.0 5.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 PIK57123.1 - 3.9e-05 23.4 0.1 0.00011 22.0 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_5 PF18037.1 PIK57123.1 - 0.00055 20.2 0.0 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 PIK57123.1 - 0.023 14.5 0.0 0.069 13.0 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 PIK57124.1 - 0.0062 16.3 0.4 0.56 10.0 0.0 3.4 2 2 1 3 3 3 1 Fungal ubiquitin-associated domain IFP_35_N PF07334.13 PIK57124.1 - 0.019 15.0 2.0 0.059 13.4 2.0 1.8 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus UBA PF00627.31 PIK57124.1 - 0.076 12.9 2.0 0.49 10.4 0.0 2.8 3 0 0 3 3 3 0 UBA/TS-N domain VWD PF00094.25 PIK57125.1 - 5.2e-11 43.1 3.3 6.1e-08 33.1 0.0 2.7 2 1 1 3 3 3 2 von Willebrand factor type D domain SoDot-IcmSS PF16848.5 PIK57125.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative EGF_CA PF07645.15 PIK57126.1 - 8e-84 275.6 265.6 6.4e-09 35.9 8.2 16.1 13 3 3 16 16 16 13 Calcium-binding EGF domain EGF_3 PF12947.7 PIK57126.1 - 3.3e-56 187.2 263.9 1.6e-10 41.0 16.3 17.4 17 0 0 17 17 17 13 EGF domain cEGF PF12662.7 PIK57126.1 - 4.4e-36 122.4 174.3 2.5e-07 30.5 6.7 16.6 16 1 0 16 16 16 11 Complement Clr-like EGF-like EGF PF00008.27 PIK57126.1 - 1.7e-22 79.4 238.6 0.00078 19.7 8.6 17.5 16 2 0 16 16 16 13 EGF-like domain hEGF PF12661.7 PIK57126.1 - 5e-18 65.0 186.6 0.0034 18.0 9.7 17.8 16 1 0 16 16 16 12 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK57126.1 - 2.8e-14 53.1 206.7 2e-06 28.0 7.8 15.9 13 2 1 14 14 14 10 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK57126.1 - 6.2e-11 42.4 246.6 0.00027 21.1 8.0 16.6 13 3 3 16 16 16 11 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK57126.1 - 7.1e-10 38.8 182.0 1.2e-05 25.3 8.5 14.7 14 1 1 15 15 15 9 MSP1 EGF domain 1 SEA PF01390.20 PIK57127.1 - 1.6e-09 37.8 0.1 4e-09 36.5 0.1 1.7 1 0 0 1 1 1 1 SEA domain EGF_2 PF07974.13 PIK57127.1 - 0.0036 17.6 7.5 0.0036 17.6 7.5 2.4 2 0 0 2 2 2 1 EGF-like domain Orthoreo_P10 PF07204.11 PIK57127.1 - 0.01 15.8 1.0 0.018 15.0 1.0 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 TMIE PF16038.5 PIK57127.1 - 0.027 14.3 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 TMIE protein EGF PF00008.27 PIK57127.1 - 0.031 14.6 3.2 0.031 14.6 3.2 2.5 2 0 0 2 2 2 0 EGF-like domain EphA2_TM PF14575.6 PIK57127.1 - 0.11 13.4 0.1 0.21 12.5 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EB PF01683.18 PIK57127.1 - 4.9 7.5 23.3 0.14 12.5 9.4 2.4 2 0 0 2 2 2 0 EB module EGF_3 PF12947.7 PIK57127.1 - 9.5 6.5 23.7 1.8 8.8 7.9 2.5 2 0 0 2 2 2 0 EGF domain WW PF00397.26 PIK57128.1 - 3.5e-07 30.2 0.2 3.5e-07 30.2 0.2 2.2 2 0 0 2 2 2 1 WW domain DUF1190 PF06693.11 PIK57128.1 - 1.2 9.5 8.0 0.4 11.1 4.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1190) Gemin7 PF11095.8 PIK57129.1 - 8.2e-26 89.7 0.2 9.2e-26 89.5 0.2 1.0 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) DUF3808 PF10300.9 PIK57130.1 - 6.6e-30 104.3 0.0 7.9e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Myb_DNA-bind_6 PF13921.6 PIK57130.1 - 0.18 12.1 0.0 4.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF3808 PF10300.9 PIK57131.1 - 8.9e-66 222.6 1.3 1.1e-65 222.2 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 PIK57131.1 - 1.4e-06 27.9 0.4 0.078 13.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK57131.1 - 0.00026 21.2 0.0 0.024 14.9 0.0 3.1 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57131.1 - 0.0004 20.4 0.0 0.018 15.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK57131.1 - 0.00087 19.8 0.1 18 6.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 PIK57131.1 - 0.0062 16.3 0.0 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 PIK57131.1 - 0.0072 15.7 0.2 4.7 6.5 0.0 2.9 2 1 1 3 3 3 2 MalT-like TPR region Op_neuropeptide PF08035.11 PIK57131.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 Opioids neuropeptide TPR_1 PF00515.28 PIK57131.1 - 0.013 15.3 0.2 0.84 9.6 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK57131.1 - 0.034 13.8 0.1 0.094 12.4 0.1 1.8 1 0 0 1 1 1 0 TPR repeat TPR_16 PF13432.6 PIK57131.1 - 0.061 14.0 0.0 0.81 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK57131.1 - 0.066 14.1 0.0 0.7 10.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fae PF08714.11 PIK57132.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Formaldehyde-activating enzyme (Fae) Neurexophilin PF06312.12 PIK57133.1 - 4.6e-09 36.0 0.0 1.5e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Neurexophilin Filamin PF00630.19 PIK57133.1 - 0.0077 17.0 0.1 0.03 15.1 0.0 1.9 2 1 0 2 2 2 1 Filamin/ABP280 repeat SET PF00856.28 PIK57134.1 - 3.6e-13 50.3 0.2 2.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 1 SET domain Mo-nitro_C PF06967.11 PIK57134.1 - 0.09 12.8 0.1 2.7 8.0 0.0 3.1 4 0 0 4 4 4 0 Mo-dependent nitrogenase C-terminus HDPD PF02924.14 PIK57135.1 - 0.0097 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 Bacteriophage lambda head decoration protein D zf-C2HC_2 PF13913.6 PIK57135.1 - 0.022 14.7 0.1 0.047 13.6 0.1 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 PIK57135.1 - 0.29 11.7 0.9 3.3 8.3 0.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type ERM PF00769.19 PIK57136.1 - 1.3e-05 25.1 102.2 0.0049 16.7 34.9 4.5 2 2 2 4 4 4 3 Ezrin/radixin/moesin family GAS PF13851.6 PIK57136.1 - 0.00069 19.0 82.8 0.0091 15.4 22.3 4.5 2 1 3 5 5 5 4 Growth-arrest specific micro-tubule binding AAA_13 PF13166.6 PIK57136.1 - 0.0007 18.4 30.5 0.0007 18.4 30.5 2.9 2 1 1 3 3 3 1 AAA domain Fez1 PF06818.15 PIK57136.1 - 0.012 16.1 80.1 0.023 15.1 29.4 4.3 1 1 3 4 4 4 0 Fez1 APG6_N PF17675.1 PIK57136.1 - 0.034 14.7 101.2 0.14 12.7 26.2 5.6 2 1 3 5 5 5 0 Apg6 coiled-coil region TPD52 PF04201.15 PIK57136.1 - 0.052 13.2 68.2 0.27 10.8 8.7 6.3 2 1 4 6 6 6 0 Tumour protein D52 family KASH_CCD PF14662.6 PIK57136.1 - 0.11 12.3 85.3 0.41 10.5 21.6 5.4 2 1 3 5 5 5 0 Coiled-coil region of CCDC155 or KASH Nsp1_C PF05064.13 PIK57136.1 - 0.35 10.7 42.2 0.096 12.5 6.8 4.7 4 0 0 4 4 4 0 Nsp1-like C-terminal region Fib_alpha PF08702.10 PIK57136.1 - 0.96 9.6 45.8 0.2 11.8 11.4 4.6 2 1 3 5 5 5 0 Fibrinogen alpha/beta chain family PilA4 PF18682.1 PIK57136.1 - 1 9.8 20.0 5.9 7.3 0.3 6.8 4 3 3 7 7 7 0 Pilin A4 ATG16 PF08614.11 PIK57136.1 - 1.2 9.4 91.3 0.94 9.7 37.8 4.7 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Glyco_transf_7N PF13733.6 PIK57136.1 - 1.7 8.3 5.3 0.61 9.7 0.2 2.9 2 2 1 3 3 3 0 N-terminal region of glycosyl transferase group 7 SCO1-SenC PF02630.14 PIK57136.1 - 4.8 7.1 8.7 9.7 6.1 1.2 3.3 1 1 3 4 4 4 0 SCO1/SenC CENP-F_leu_zip PF10473.9 PIK57136.1 - 5.9 6.9 86.8 0.35 10.9 2.8 4.7 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.10 PIK57136.1 - 9.6 6.6 65.8 0.063 13.7 16.5 4.6 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) NACHT PF05729.12 PIK57137.1 - 1.7e-17 63.8 0.0 9.5e-17 61.4 0.0 2.3 2 0 0 2 2 2 1 NACHT domain ZU5 PF00791.20 PIK57137.1 - 3.7e-09 36.8 0.0 1.1e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 ZU5 domain AAA_25 PF13481.6 PIK57137.1 - 5.4e-05 22.8 0.0 0.0034 17.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 PIK57137.1 - 0.0005 19.5 0.0 0.0014 18.0 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA PF00004.29 PIK57137.1 - 0.0041 17.6 0.0 0.0093 16.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DAP3 PF10236.9 PIK57137.1 - 0.066 12.4 0.0 0.21 10.8 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_5 PF07728.14 PIK57137.1 - 0.13 12.2 0.2 0.82 9.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ZU5 PF00791.20 PIK57138.1 - 0.013 15.8 0.0 0.029 14.7 0.0 1.6 1 0 0 1 1 1 0 ZU5 domain Acyl_transf_3 PF01757.22 PIK57139.1 - 1.3e-06 27.8 27.1 0.0005 19.2 22.5 2.4 2 0 0 2 2 2 2 Acyltransferase family Peptidase_A17 PF05380.13 PIK57139.1 - 1.3e-05 25.2 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase Wzy_C PF04932.15 PIK57139.1 - 0.36 10.4 8.2 2 8.0 0.2 3.2 3 0 0 3 3 3 0 O-Antigen ligase Neurexophilin PF06312.12 PIK57140.1 - 3.1e-14 53.0 0.1 5.5e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 PIK57140.1 - 0.05 14.4 0.0 0.13 13.1 0.0 1.7 1 0 0 1 1 1 0 Filamin/ABP280 repeat DUF2326 PF10088.9 PIK57140.1 - 0.12 12.1 0.0 9 6.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2326) Pkinase_Tyr PF07714.17 PIK57141.1 - 5.7e-21 75.0 0.0 8.6e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK57141.1 - 1.4e-13 50.9 0.0 2.1e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK57141.1 - 4.5e-05 23.4 3.6 0.0029 17.6 0.1 3.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK57141.1 - 0.0015 18.8 0.3 0.0015 18.8 0.3 2.4 3 0 0 3 3 3 1 Immunoglobulin C1-set domain ig PF00047.25 PIK57141.1 - 0.0017 18.5 0.9 0.01 16.0 0.4 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK57141.1 - 0.0027 18.3 2.8 0.28 11.8 0.2 3.1 3 0 0 3 3 3 1 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK57142.1 - 1.1e-24 87.1 0.0 1.6e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK57142.1 - 3.1e-16 59.5 0.0 6.1e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK57142.1 - 1.8e-09 37.5 4.0 1.9e-05 24.6 0.1 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK57142.1 - 0.00084 19.9 2.3 0.21 12.2 0.2 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK57142.1 - 0.0018 18.6 2.3 0.1 12.9 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK57142.1 - 0.047 13.9 3.9 2.9 8.1 0.2 2.6 2 0 0 2 2 2 0 Immunoglobulin domain DED PF01335.21 PIK57143.1 - 6.5e-12 45.6 2.0 6.5e-12 45.6 2.0 3.2 2 1 1 3 3 3 1 Death effector domain zf-B_box PF00643.24 PIK57143.1 - 4.4e-05 23.5 6.0 8.4e-05 22.6 6.0 1.5 1 0 0 1 1 1 1 B-box zinc finger DNA_topoisoIV PF00521.20 PIK57143.1 - 1.6 7.5 17.5 0.27 10.1 13.6 1.6 2 0 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A DUF5340 PF17275.2 PIK57143.1 - 4.9 7.4 8.3 4.3 7.6 3.3 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5340) DED PF01335.21 PIK57144.1 - 1.8e-12 47.4 1.1 1.8e-12 47.4 1.1 3.8 3 2 1 4 4 4 1 Death effector domain zf-B_box PF00643.24 PIK57144.1 - 9.2e-06 25.7 6.5 1.9e-05 24.7 6.5 1.5 1 0 0 1 1 1 1 B-box zinc finger HTH_WhiA PF02650.14 PIK57144.1 - 0.84 10.0 9.7 0.14 12.5 3.7 2.6 1 1 1 2 2 2 0 WhiA C-terminal HTH domain FliT PF05400.13 PIK57144.1 - 2.6 8.9 15.1 0.67 10.8 7.7 3.3 3 1 0 3 3 3 0 Flagellar protein FliT DUF5340 PF17275.2 PIK57144.1 - 5.8 7.1 9.5 4.9 7.3 4.6 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5340) DNA_topoisoIV PF00521.20 PIK57144.1 - 6.1 5.6 17.3 11 4.7 17.2 1.5 1 1 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DED PF01335.21 PIK57145.1 - 6.5e-12 45.6 1.7 6.5e-12 45.6 1.7 3.1 2 1 0 2 2 2 1 Death effector domain zf-B_box PF00643.24 PIK57145.1 - 3.8e-06 27.0 7.5 9.2e-06 25.7 7.5 1.7 1 0 0 1 1 1 1 B-box zinc finger Qua1 PF16274.5 PIK57145.1 - 0.069 13.0 1.4 0.21 11.4 1.4 1.8 1 0 0 1 1 1 0 Qua1 domain IBR PF01485.21 PIK57145.1 - 0.3 11.4 4.6 0.79 10.0 4.6 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain SKA2 PF16740.5 PIK57145.1 - 2.4 8.0 9.9 3 7.7 0.0 3.0 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 RFX_DNA_binding PF02257.15 PIK57147.1 - 6.3e-31 106.8 0.4 1.1e-30 106.1 0.4 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 PIK57147.1 - 0.0026 18.2 0.1 0.0046 17.4 0.1 1.5 1 0 0 1 1 1 1 Poxvirus D5 protein-like REJ PF02010.15 PIK57148.1 - 1.4e-29 103.2 7.8 2.1e-29 102.6 7.8 1.2 1 0 0 1 1 1 1 REJ domain GPS PF01825.21 PIK57148.1 - 0.085 13.4 1.0 0.27 11.8 1.0 1.9 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif REJ PF02010.15 PIK57149.1 - 2.1e-36 125.7 8.9 1.7e-27 96.3 4.6 2.1 1 1 1 2 2 2 2 REJ domain Glyco_transf_10 PF00852.19 PIK57150.1 - 6.3e-45 153.0 1.2 1e-44 152.4 1.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK57150.1 - 1.7e-08 34.9 0.1 3.5e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DED PF01335.21 PIK57151.1 - 8.6e-13 48.4 2.0 8.6e-13 48.4 2.0 1.7 2 0 0 2 2 2 1 Death effector domain zf-B_box PF00643.24 PIK57151.1 - 8e-07 29.1 6.5 8e-07 29.1 6.5 1.6 2 0 0 2 2 2 1 B-box zinc finger HSCB_C PF07743.13 PIK57151.1 - 0.21 12.1 2.9 0.3 11.6 0.3 2.1 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain ATF7IP_BD PF16788.5 PIK57152.1 - 0.011 15.8 1.6 0.017 15.2 1.6 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain Fibrinogen_C PF00147.18 PIK57153.1 - 3.3e-31 108.8 3.0 8.6e-12 45.3 0.2 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK57153.1 - 0.00015 21.9 9.0 0.00015 21.9 9.0 3.6 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK57153.1 - 0.00047 20.1 3.3 0.00047 20.1 3.3 3.5 1 1 2 3 3 3 1 TILa domain Fibrinogen_C PF00147.18 PIK57154.1 - 5.5e-27 95.0 3.6 9.4e-20 71.4 0.3 2.5 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57154.1 - 9.9e-05 22.2 4.5 9.9e-05 22.2 4.5 2.9 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK57154.1 - 0.0018 18.4 9.4 0.0018 18.4 9.4 3.2 2 2 1 3 3 3 1 EGF domain DUF1799 PF08809.11 PIK57154.1 - 0.033 14.4 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 Phage related hypothetical protein (DUF1799) Fibrinogen_C PF00147.18 PIK57155.1 - 2.6e-20 73.2 0.3 2.9e-20 73.0 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Sugar_tr PF00083.24 PIK57156.1 - 5.5e-11 42.0 0.8 8.8e-11 41.3 0.3 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter wnt PF00110.19 PIK57158.1 - 1.4e-103 346.7 26.1 1.6e-103 346.6 26.1 1.0 1 0 0 1 1 1 1 wnt family Use1 PF09753.9 PIK57159.1 - 2.3e-54 184.7 2.2 2.7e-54 184.5 2.2 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 PyrI PF01948.18 PIK57159.1 - 0.067 13.4 0.4 0.13 12.5 0.4 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain Dfp1_Him1_M PF08630.10 PIK57159.1 - 0.14 12.3 0.8 0.73 10.1 0.0 2.2 2 0 0 2 2 2 0 Dfp1/Him1, central region Glyco_hydro_31 PF01055.26 PIK57160.1 - 1.1e-50 173.2 3.2 3.3e-50 171.6 3.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase PF02065.18 PIK57160.1 - 0.0002 20.4 0.1 0.00029 19.9 0.1 1.2 1 0 0 1 1 1 1 Melibiase DUF2856 PF11043.8 PIK57160.1 - 0.14 12.3 0.1 0.54 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) SpoVIF PF14069.6 PIK57160.1 - 0.16 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Stage VI sporulation protein F RNB PF00773.19 PIK57161.1 - 8.8e-88 294.8 0.1 1.3e-87 294.2 0.1 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 PIK57161.1 - 1.4e-13 50.7 0.0 4.9e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 PIK57161.1 - 4.7e-07 29.7 0.0 1.4e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 PIK57161.1 - 1.2e-06 28.3 0.0 2.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 PIK57161.1 - 1.4e-05 25.2 0.0 0.06 13.5 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain DUF5444 PF17519.2 PIK57161.1 - 0.18 11.8 0.0 0.47 10.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5444) Swi3 PF07962.12 PIK57162.1 - 9.5e-28 96.0 0.9 1.5e-27 95.4 0.9 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 TB2_DP1_HVA22 PF03134.19 PIK57164.1 - 8.8e-21 73.6 1.0 1.6e-20 72.8 1.0 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family LRR_9 PF14580.6 PIK57165.1 - 2.2e-21 76.1 12.1 2.1e-11 43.6 0.2 4.4 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 PIK57165.1 - 6.4e-13 48.7 17.8 7.7e-05 23.0 0.6 5.7 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57165.1 - 1.1e-09 37.9 19.5 0.012 15.4 0.2 5.7 4 1 1 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 PIK57165.1 - 0.29 11.3 2.1 7 7.0 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 PIK57166.1 - 2.3e-28 97.7 23.6 5.5e-10 38.9 2.4 5.4 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 PIK57166.1 - 2.4e-21 75.5 24.8 8.1e-07 29.3 2.0 6.1 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK57166.1 - 4e-07 29.7 9.8 0.0023 17.4 1.4 3.0 2 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK57166.1 - 5.2e-06 26.3 22.7 0.92 10.3 0.2 7.5 7 2 1 8 8 8 4 Leucine Rich Repeat LRR_6 PF13516.6 PIK57166.1 - 0.072 13.2 19.4 0.93 9.7 0.2 5.6 6 0 0 6 6 6 0 Leucine Rich repeat Na_Ca_ex PF01699.24 PIK57167.1 - 8e-24 84.3 9.9 9.7e-24 84.0 9.9 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF1129 PF06570.11 PIK57167.1 - 0.28 10.7 3.1 6.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Na_Ca_ex PF01699.24 PIK57168.1 - 6.3e-22 78.2 13.8 9.8e-22 77.5 13.8 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Methyltransf_25 PF13649.6 PIK57169.1 - 5.3e-05 23.8 0.0 0.00011 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK57169.1 - 0.0027 18.4 0.0 0.01 16.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK57169.1 - 0.003 18.2 0.0 0.0063 17.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain RhoGAP PF00620.27 PIK57170.1 - 3.9e-44 150.1 2.3 7.6e-44 149.2 0.3 2.4 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 PIK57170.1 - 3.6e-07 30.0 13.3 9.4e-07 28.6 13.3 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3275 PF11679.8 PIK57170.1 - 0.0057 16.7 0.3 0.0057 16.7 0.3 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3275) C1_2 PF03107.16 PIK57170.1 - 2.4 8.5 10.3 6.6 7.1 10.3 1.7 1 0 0 1 1 1 0 C1 domain Myosin_head PF00063.21 PIK57171.1 - 6.3e-106 355.2 10.0 5.4e-70 236.4 1.4 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) IQ PF00612.27 PIK57171.1 - 7.4e-11 40.9 19.0 0.003 17.2 0.4 5.0 4 0 0 4 4 4 4 IQ calmodulin-binding motif RNA_GG_bind PF10258.9 PIK57172.1 - 6.4e-28 96.6 0.0 1.6e-27 95.3 0.0 1.7 1 0 0 1 1 1 1 PHAX RNA-binding domain TB2_DP1_HVA22 PF03134.19 PIK57173.1 - 1.9e-29 101.4 2.3 1.9e-29 101.4 2.3 1.9 2 0 0 2 2 2 1 TB2/DP1, HVA22 family FA_desaturase PF00487.24 PIK57173.1 - 4.1 7.2 8.5 10 5.9 8.5 1.6 1 1 0 1 1 1 0 Fatty acid desaturase ARTD15_N PF18084.1 PIK57174.1 - 1.1e-26 92.9 0.1 2.6e-26 91.7 0.1 1.7 1 0 0 1 1 1 1 ARTD15 N-terminal domain PARP PF00644.20 PIK57174.1 - 2.4e-24 86.0 0.3 1.2e-23 83.7 0.3 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ArlS_N PF18719.1 PIK57174.1 - 0.081 13.1 0.1 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 ArlS sensor domain COX7a PF02238.15 PIK57174.1 - 0.09 13.2 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII Exotox-A_cataly PF09009.10 PIK57174.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A catalytic Atx10homo_assoc PF09759.9 PIK57175.1 - 7.4e-07 29.1 0.3 0.00011 22.2 0.1 2.3 1 1 1 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 PIK57175.1 - 2.8e-06 27.2 1.5 0.0021 18.0 0.2 2.6 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat RVT_1 PF00078.27 PIK57176.1 - 1.6e-20 73.5 0.0 2.1e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltransf_31 PF13847.6 PIK57178.1 - 4.1e-06 26.7 0.0 6.2e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK57178.1 - 3.5e-05 24.4 0.0 6.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK57178.1 - 0.0001 22.2 0.0 0.00013 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK57178.1 - 0.012 16.4 0.0 0.032 15.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Dimerisation2 PF16864.5 PIK57178.1 - 0.047 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain DUF4704 PF15787.5 PIK57179.1 - 2e-96 322.6 0.8 2e-96 322.6 0.8 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 PIK57179.1 - 3.6e-14 53.2 0.0 6.8e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GST_C_4 PF14834.6 PIK57179.1 - 0.057 13.8 0.1 0.58 10.6 0.0 2.5 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Arm_vescicular PF18770.1 PIK57179.1 - 0.061 13.3 0.5 6.4 6.8 0.0 3.0 2 0 0 2 2 2 0 Armadillo tether-repeat of vescicular transport factor Ig_2 PF13895.6 PIK57181.1 - 1.4e-06 28.5 0.1 0.00096 19.5 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK57181.1 - 6.3e-06 26.7 0.1 0.0001 22.8 0.0 2.9 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK57181.1 - 0.00018 21.6 0.0 0.0014 18.8 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK57181.1 - 0.00096 19.5 0.0 0.0043 17.4 0.0 2.1 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 PIK57181.1 - 0.0016 18.5 0.0 0.0052 16.9 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_4 PF16680.5 PIK57181.1 - 0.0041 17.4 0.0 0.0083 16.4 0.0 1.6 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 PIK57181.1 - 0.011 15.8 0.0 0.029 14.4 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain LRR_9 PF14580.6 PIK57183.1 - 9.6e-18 64.3 0.8 4e-17 62.3 0.8 1.9 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK57183.1 - 8.3e-15 54.7 5.8 2.2e-07 31.1 0.4 3.5 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57183.1 - 3.4e-11 42.7 5.3 3.2e-07 30.0 2.9 3.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 PIK57183.1 - 0.00024 20.9 8.7 0.097 12.8 0.2 4.4 4 0 0 4 4 4 2 Leucine Rich repeat YscO PF07321.12 PIK57183.1 - 0.0045 16.9 14.8 0.0095 15.9 14.8 1.5 1 0 0 1 1 1 1 Type III secretion protein YscO LRR_1 PF00560.33 PIK57183.1 - 0.022 15.2 9.7 3.3 8.6 0.2 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat Exonuc_VII_L PF02601.15 PIK57183.1 - 0.086 12.4 9.4 0.081 12.5 3.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit FOXP-CC PF16159.5 PIK57183.1 - 0.61 10.8 6.4 0.19 12.4 0.7 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain Prominin PF05478.11 PIK57183.1 - 0.64 7.9 5.9 0.12 10.3 2.5 1.4 2 0 0 2 2 2 0 Prominin Fmp27_WPPW PF10359.9 PIK57183.1 - 0.91 8.3 9.5 1.4 7.7 9.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FapA PF03961.13 PIK57183.1 - 1.2 7.6 7.9 2.4 6.7 7.9 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A FliD_C PF07195.12 PIK57183.1 - 1.4 8.3 6.8 0.78 9.1 3.0 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Lectin_N PF03954.14 PIK57183.1 - 1.5 8.6 6.3 7.1 6.4 2.3 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4407 PF14362.6 PIK57183.1 - 2.8 7.2 9.1 6.2 6.1 9.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TelA PF05816.11 PIK57183.1 - 5 6.1 18.2 0.13 11.3 4.9 2.6 3 1 1 4 4 4 0 Toxic anion resistance protein (TelA) CENP-Q PF13094.6 PIK57183.1 - 6.2 7.0 19.3 96 3.1 1.9 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CCDC-167 PF15188.6 PIK57183.1 - 7.8 6.9 17.7 0.3 11.4 0.7 3.5 4 0 0 4 4 3 0 Coiled-coil domain-containing protein 167 DUF2730 PF10805.8 PIK57183.1 - 7.9 6.6 10.3 0.9 9.7 3.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF812 PF05667.11 PIK57185.1 - 2.1e-06 26.9 30.1 2.1e-06 26.9 30.1 5.0 1 1 3 4 4 4 1 Protein of unknown function (DUF812) DUF4200 PF13863.6 PIK57185.1 - 1.5e-05 25.4 14.1 1.5e-05 25.4 14.1 9.9 3 3 6 10 10 10 3 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.9 PIK57185.1 - 0.0028 17.7 7.5 0.0028 17.7 7.5 9.1 1 1 6 8 8 8 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vac_Fusion PF02346.16 PIK57185.1 - 0.003 17.1 1.4 0.003 17.1 1.4 8.0 6 3 4 11 11 11 2 Chordopoxvirus multifunctional envelope protein A27 MPS2 PF17060.5 PIK57185.1 - 0.0042 16.4 4.1 0.0042 16.4 4.1 6.3 1 1 4 6 6 6 1 Monopolar spindle protein 2 ADIP PF11559.8 PIK57185.1 - 0.01 15.9 157.5 0.39 10.8 22.8 9.5 2 1 7 10 10 10 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 PIK57185.1 - 0.24 10.2 170.4 0.018 14.0 22.2 7.7 1 1 6 7 7 7 0 Spc7 kinetochore protein Band_7 PF01145.25 PIK57186.1 - 1.3e-22 80.6 0.0 1.7e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family SNN_linker PF09050.10 PIK57186.1 - 0.072 12.9 2.8 0.23 11.3 2.8 1.8 1 1 0 1 1 1 0 Stannin unstructured linker GP68 PF17469.2 PIK57187.1 - 0.032 14.6 1.1 0.055 13.9 0.7 1.6 1 1 0 1 1 1 0 Phage protein Gp68 Band_7 PF01145.25 PIK57187.1 - 0.087 12.8 0.3 0.12 12.4 0.3 1.2 1 0 0 1 1 1 0 SPFH domain / Band 7 family CALM_bind PF16025.5 PIK57187.1 - 0.099 13.1 0.3 0.15 12.6 0.3 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Gal_Lectin PF02140.18 PIK57188.1 - 4.8e-17 62.1 1.8 1.1e-16 61.0 1.8 1.6 1 0 0 1 1 1 1 Galactose binding lectin domain Ras PF00071.22 PIK57189.1 - 6.9e-36 123.3 0.0 7.9e-36 123.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57189.1 - 7e-19 68.2 0.0 8.8e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57189.1 - 0.0026 17.2 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 PIK57190.1 - 2.2e-30 105.4 0.0 1.2e-24 86.7 0.0 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK57190.1 - 2.6e-12 47.0 0.0 3.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57190.1 - 0.00025 20.5 0.0 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Nore1-SARAH PF16517.5 PIK57191.1 - 1.2e-16 60.3 1.4 2.7e-16 59.2 1.4 1.6 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.23 PIK57191.1 - 1.8e-11 44.5 0.1 4.8e-11 43.1 0.1 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 PIK57191.1 - 3.2e-08 33.3 14.5 5.7e-08 32.5 14.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PRMT5 PF05185.16 PIK57191.1 - 0.053 13.4 0.3 0.12 12.2 0.3 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Annexin PF00191.20 PIK57191.1 - 0.13 12.4 0.2 2.5 8.2 0.2 2.5 2 0 0 2 2 2 0 Annexin Mst1_SARAH PF11629.8 PIK57191.1 - 0.16 12.0 7.7 0.49 10.5 0.6 2.7 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 4HB_MCP_1 PF12729.7 PIK57191.1 - 0.46 10.0 6.5 0.054 13.0 0.9 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction zf-RING_9 PF13901.6 PIK57191.1 - 1.6 8.7 14.1 0.36 10.8 10.4 1.8 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon zf-CCCH_4 PF18044.1 PIK57192.1 - 2.6e-21 75.0 41.8 8.7e-07 28.6 5.3 4.8 4 0 0 4 4 4 4 CCCH-type zinc finger zf-CCCH PF00642.24 PIK57192.1 - 1e-14 54.0 36.5 0.00018 21.4 3.1 4.7 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 PIK57192.1 - 1.3e-14 54.8 17.5 8.3e-05 23.2 0.5 4.7 3 1 1 4 4 4 4 Torus domain zf_CCCH_4 PF18345.1 PIK57192.1 - 2e-11 43.5 48.9 0.0019 18.2 9.2 5.2 4 1 0 4 4 4 4 Zinc finger domain zf-C3HC4 PF00097.25 PIK57192.1 - 1.2e-06 28.3 11.8 1.2e-06 28.3 11.8 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK57192.1 - 1.2e-05 25.5 10.6 1.2e-05 25.5 10.6 4.1 4 2 1 5 5 4 1 Ring finger domain zf-CCCH_3 PF15663.5 PIK57192.1 - 5e-05 23.5 5.1 5e-05 23.5 5.1 3.5 3 1 0 3 3 3 1 Zinc-finger containing family zf-RING_5 PF14634.6 PIK57192.1 - 0.00012 21.9 10.6 0.00012 21.9 10.6 3.3 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 PIK57192.1 - 0.00096 19.4 9.5 0.00096 19.4 9.5 3.2 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK57192.1 - 0.0032 17.5 6.5 0.0032 17.5 6.5 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK57192.1 - 0.013 15.7 5.8 0.013 15.7 5.8 3.3 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK57192.1 - 0.45 10.4 15.2 0.059 13.2 9.0 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-CCCH_2 PF14608.6 PIK57192.1 - 0.55 10.8 52.3 0.063 13.8 4.5 5.3 6 0 0 6 6 4 0 RNA-binding, Nab2-type zinc finger rve PF00665.26 PIK57193.1 - 2.3e-16 60.1 0.0 4.2e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK57193.1 - 7.4e-16 58.0 0.1 1.5e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK57193.1 - 0.046 14.0 0.4 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK57193.1 - 0.061 13.6 0.3 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 DDE domain RVT_1 PF00078.27 PIK57194.1 - 9.6e-16 58.0 0.0 1.5e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mg_trans_NIPA PF05653.14 PIK57195.1 - 8.9e-114 379.6 16.8 1.1e-113 379.2 16.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 PIK57195.1 - 0.00026 21.2 5.2 0.00026 21.2 5.2 4.7 4 1 0 4 4 4 1 EamA-like transporter family Multi_Drug_Res PF00893.19 PIK57195.1 - 3.1 8.5 9.5 0.9 10.2 1.7 3.6 2 2 1 3 3 3 0 Small Multidrug Resistance protein Glyco_transf_10 PF00852.19 PIK57196.1 - 4.8e-47 160.0 1.3 7e-47 159.4 1.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK57196.1 - 0.0008 19.8 0.0 0.0027 18.1 0.0 1.9 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal DUF3772 PF12607.8 PIK57196.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) BLOC1_2 PF10046.9 PIK57198.1 - 0.028 14.7 1.4 0.45 10.9 0.2 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Gtr1_RagA PF04670.12 PIK57198.1 - 0.032 13.6 0.2 0.062 12.6 0.2 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Repressor_Mnt PF11423.8 PIK57198.1 - 0.046 13.5 0.1 0.14 11.9 0.1 1.9 2 0 0 2 2 2 0 Regulatory protein Mnt Myosin_tail_1 PF01576.19 PIK57198.1 - 0.11 10.3 0.3 0.16 9.8 0.3 1.1 1 0 0 1 1 1 0 Myosin tail DUF1664 PF07889.12 PIK57198.1 - 0.15 12.1 1.0 1.1 9.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 PIK57198.1 - 0.17 12.3 0.4 0.7 10.3 0.4 2.1 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DNA_pol_phi PF04931.13 PIK57199.1 - 0.13 10.4 2.8 3.3 5.7 0.1 2.1 2 0 0 2 2 2 0 DNA polymerase phi Preseq_ALAS PF09029.10 PIK57201.1 - 0.086 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence DUF3443 PF11925.8 PIK57204.1 - 0.00083 18.3 0.3 0.0012 17.7 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3443) CytochromB561_N PF09786.9 PIK57206.1 - 1.5e-76 258.6 0.0 1.8e-76 258.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal Katanin_con80 PF13925.6 PIK57207.1 - 3.1e-06 27.3 0.1 5.6e-06 26.5 0.1 1.4 1 1 0 1 1 1 1 con80 domain of Katanin BetaGal_dom4_5 PF13364.6 PIK57207.1 - 0.11 13.1 0.0 1.5 9.4 0.0 2.1 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain DUF4619 PF15398.6 PIK57208.1 - 0.0015 18.1 0.5 0.0018 17.9 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4619) Ndc1_Nup PF09531.10 PIK57209.1 - 0.87 8.2 7.7 0.92 8.1 7.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 PIK57209.1 - 1.2 7.4 4.0 1.2 7.4 4.0 1.0 1 0 0 1 1 1 0 Menin Homeobox_KN PF05920.11 PIK57210.1 - 2.3e-19 69.0 1.4 4.5e-19 68.1 1.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 PIK57210.1 - 1.6e-07 31.1 0.3 3.4e-07 30.0 0.3 1.5 1 0 0 1 1 1 1 Homeodomain Dicty_REP PF05086.12 PIK57210.1 - 0.23 9.4 4.8 0.29 9.1 4.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRCR PF00530.18 PIK57211.1 - 3.3e-98 322.8 36.1 2.3e-26 92.2 10.0 5.1 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK57211.1 - 5.9e-16 58.8 18.5 0.00081 19.9 4.3 4.6 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK57211.1 - 2.5e-12 47.3 5.7 0.03 14.9 0.1 4.7 3 1 0 4 4 4 4 Hepsin, SRCR domain Mon2_C PF16206.5 PIK57212.1 - 0.044 11.9 0.1 0.067 11.3 0.1 1.1 1 0 0 1 1 1 0 C-terminal region of Mon2 protein CAP PF00188.26 PIK57212.1 - 7.5 7.4 12.1 3.8 8.4 0.1 4.3 3 1 0 3 3 3 0 Cysteine-rich secretory protein family F5_F8_type_C PF00754.25 PIK57213.1 - 8.8e-06 25.9 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain Fibrinogen_C PF00147.18 PIK57214.1 - 2e-44 152.0 13.8 2.6e-44 151.7 13.2 1.4 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TPR_19 PF14559.6 PIK57216.1 - 1.3e-09 38.4 1.6 0.0088 16.5 0.1 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK57216.1 - 3.8e-08 33.2 0.0 0.34 11.4 0.0 6.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK57216.1 - 9.1e-08 31.7 6.4 1.1 9.6 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK57216.1 - 4e-07 30.6 0.2 0.41 11.3 0.0 4.9 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK57216.1 - 5.1e-07 30.0 0.4 4.2 8.4 0.0 6.2 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK57216.1 - 8.1e-07 29.3 4.4 0.23 11.8 0.0 5.4 4 2 1 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK57216.1 - 8.8e-06 25.4 1.5 5.3 7.3 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK57216.1 - 1.8e-05 24.4 0.9 2.9 7.9 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat SNAP PF14938.6 PIK57216.1 - 0.00013 21.5 5.0 0.0038 16.7 2.8 2.4 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 PIK57216.1 - 0.0038 17.8 2.5 0.3 11.8 0.2 5.0 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57216.1 - 0.006 16.7 11.4 12 6.4 0.0 6.9 7 1 0 7 7 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK57216.1 - 0.031 14.0 0.0 26 4.6 0.0 4.1 3 0 0 3 3 3 0 TPR repeat PPR PF01535.20 PIK57216.1 - 0.033 14.4 0.0 27 5.3 0.0 4.2 3 0 0 3 3 3 0 PPR repeat ANAPC3 PF12895.7 PIK57216.1 - 0.25 11.6 5.1 16 5.8 0.0 3.9 5 1 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 PIK57216.1 - 0.29 10.8 3.6 0.59 9.8 0.8 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 PIK57216.1 - 1.1 9.2 4.1 72 3.5 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat HLH PF00010.26 PIK57217.1 - 3.6e-15 55.7 0.1 3.6e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Fibrinogen_C PF00147.18 PIK57218.1 - 7.5e-56 189.4 1.8 9.2e-56 189.1 1.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK57219.1 - 9.2e-37 127.0 2.2 1.3e-36 126.5 2.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK57219.1 - 4.2e-07 30.1 12.4 4.2e-07 30.1 12.4 1.8 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK57220.1 - 8.7e-64 215.3 13.5 2e-39 135.7 0.3 2.4 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK57220.1 - 1.9e-06 28.0 15.3 1.9e-06 28.0 15.3 2.4 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK57221.1 - 1.1e-23 84.2 0.6 1.4e-23 83.9 0.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57221.1 - 4.4e-11 42.6 9.0 4.4e-11 42.6 9.0 3.3 2 1 1 3 3 3 1 TILa domain TIL PF01826.17 PIK57221.1 - 0.00087 19.5 16.0 0.00087 19.5 16.0 3.1 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK57222.1 - 5e-69 232.5 9.5 1.6e-36 126.2 1.6 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57222.1 - 4.6e-11 42.5 11.3 4.6e-11 42.5 11.3 2.2 2 1 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK57222.1 - 0.59 10.4 23.6 43 4.4 23.6 3.0 1 1 0 1 1 1 0 EGF domain VWC PF00093.18 PIK57222.1 - 1.5 9.2 21.5 0.061 13.7 14.0 2.5 2 1 1 3 3 3 0 von Willebrand factor type C domain Fibrinogen_C PF00147.18 PIK57223.1 - 1.4e-81 273.5 13.4 6.5e-41 140.5 6.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK57223.1 - 5.6e-08 32.9 10.9 5.6e-08 32.9 10.9 2.7 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 PIK57223.1 - 2.4 8.1 20.1 0.27 11.2 1.3 4.4 5 0 0 5 5 5 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK57224.1 - 4.7e-27 95.2 3.7 5.5e-27 95.0 3.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK57225.1 - 3.1e-55 187.4 17.0 1e-32 113.8 7.2 3.4 1 1 2 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK57225.1 - 6.3e-07 29.5 16.4 6.3e-07 29.5 16.4 2.6 4 0 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK57226.1 - 7.4e-08 32.2 13.1 7.4e-08 32.2 13.1 3.3 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK57226.1 - 2.4e-07 30.9 14.5 2.4e-07 30.9 14.5 3.5 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK57226.1 - 0.00016 21.6 0.0 0.0003 20.6 0.0 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK57226.1 - 0.0092 16.2 14.5 0.0092 16.2 14.5 4.6 2 2 1 3 3 3 1 EGF domain MR_MLE_C PF13378.6 PIK57227.1 - 4.2e-42 144.2 0.2 2.7e-40 138.3 0.0 2.2 1 1 1 2 2 2 2 Enolase C-terminal domain-like MR_MLE_N PF02746.16 PIK57227.1 - 4.6e-10 39.7 0.0 7.5e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain JAB PF01398.21 PIK57228.1 - 3.2e-35 120.6 0.1 4.9e-35 120.1 0.1 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 PIK57228.1 - 3.1e-21 76.1 0.6 5.1e-21 75.4 0.6 1.4 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 PIK57228.1 - 9.9e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 PIK57228.1 - 0.00032 20.8 0.3 0.00058 20.0 0.1 1.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) DUF2781 PF10914.8 PIK57229.1 - 1.7 9.0 20.0 14 6.1 0.1 5.1 2 1 2 5 5 5 0 Protein of unknown function (DUF2781) DUF410 PF04190.13 PIK57230.1 - 5.5e-70 236.1 0.0 6.5e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TILa PF12714.7 PIK57230.1 - 5.4e-05 23.1 8.2 5.4e-05 23.1 8.2 2.5 2 1 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK57230.1 - 5.9e-05 23.2 2.9 5.9e-05 23.2 2.9 3.8 3 1 0 3 3 3 1 EGF domain TIL PF01826.17 PIK57230.1 - 0.021 15.0 9.0 0.021 15.0 9.0 3.3 2 1 1 3 3 3 0 Trypsin Inhibitor like cysteine rich domain IgGFc_binding PF17517.2 PIK57231.1 - 3.7e-30 105.2 0.4 6.1e-30 104.5 0.4 1.3 1 0 0 1 1 1 1 IgGFc binding protein AMOP PF03782.17 PIK57231.1 - 1.4e-15 57.6 6.2 8.3e-15 55.1 6.2 2.1 1 1 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK57231.1 - 0.0082 16.4 0.0 0.052 13.8 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type D domain Anth_Ig PF05587.13 PIK57231.1 - 0.015 15.6 0.0 0.041 14.2 0.0 1.8 1 1 0 1 1 1 0 Anthrax receptor extracellular domain Sushi PF00084.20 PIK57232.1 - 3.6e-17 62.7 1.0 3.9e-10 40.2 0.0 2.4 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) VWD PF00094.25 PIK57232.1 - 1.5e-08 35.1 0.0 3.5e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type D domain TMEM154 PF15102.6 PIK57232.1 - 0.00017 21.5 0.1 0.00033 20.6 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family Tmemb_9 PF05434.11 PIK57232.1 - 0.00035 20.5 0.4 0.00064 19.6 0.4 1.4 1 0 0 1 1 1 1 TMEM9 HRM PF02793.22 PIK57232.1 - 0.0021 18.3 0.1 3 8.2 0.0 2.4 2 0 0 2 2 2 2 Hormone receptor domain MLANA PF14991.6 PIK57232.1 - 0.015 15.6 0.8 0.09 13.1 0.8 2.0 1 1 0 1 1 1 0 Protein melan-A SIT PF15330.6 PIK57232.1 - 0.024 15.1 0.1 0.045 14.2 0.1 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Comm PF15957.5 PIK57232.1 - 0.025 14.9 0.4 0.046 14.1 0.4 1.4 1 0 0 1 1 1 0 Commissureless EphA2_TM PF14575.6 PIK57232.1 - 0.029 15.2 0.2 0.069 14.0 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3377 PF11857.8 PIK57232.1 - 0.051 13.5 1.1 0.099 12.6 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Sigma_reg_N PF13800.6 PIK57232.1 - 0.11 12.8 0.5 0.24 11.7 0.5 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DAG1 PF05454.11 PIK57232.1 - 0.13 11.6 0.2 0.26 10.6 0.2 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Ly49 PF08391.10 PIK57232.1 - 0.15 12.4 1.1 0.27 11.6 1.1 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region PAG PF15347.6 PIK57232.1 - 0.26 10.3 1.2 0.26 10.3 0.3 1.4 2 0 0 2 2 2 0 Phosphoprotein associated with glycosphingolipid-enriched IgGFc_binding PF17517.2 PIK57233.1 - 8.3e-54 182.8 16.0 1.9e-52 178.3 7.0 2.3 2 0 0 2 2 2 2 IgGFc binding protein AMOP PF03782.17 PIK57233.1 - 3.4e-23 82.3 5.4 5.5e-13 49.2 2.8 2.8 2 1 0 2 2 2 2 AMOP domain Sushi PF00084.20 PIK57233.1 - 5.1e-21 75.0 3.6 1.1e-09 38.7 0.5 2.7 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) VWD PF00094.25 PIK57233.1 - 4.9e-15 56.1 0.0 1.5e-14 54.5 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type D domain HRM PF02793.22 PIK57233.1 - 0.082 13.2 2.5 2.5 8.4 0.5 2.5 2 0 0 2 2 2 0 Hormone receptor domain IgGFc_binding PF17517.2 PIK57234.1 - 6.3e-49 166.8 12.0 1.8e-48 165.4 5.8 2.5 2 0 0 2 2 2 2 IgGFc binding protein AMOP PF03782.17 PIK57234.1 - 2.1e-10 40.9 3.7 6.1e-10 39.4 3.7 1.7 1 1 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK57234.1 - 7.7e-08 32.8 0.0 2.9e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type D domain Sushi PF00084.20 PIK57235.1 - 2.4e-20 72.9 2.8 5.3e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.22 PIK57235.1 - 0.0026 18.0 0.9 0.1 12.9 0.5 2.3 2 0 0 2 2 2 1 Hormone receptor domain Lectin_C PF00059.21 PIK57236.1 - 3.2e-14 53.6 0.2 4.9e-14 53.0 0.2 1.3 1 0 0 1 1 1 1 Lectin C-type domain Calx-beta PF03160.14 PIK57236.1 - 0.015 15.4 0.4 0.27 11.4 0.1 3.0 2 2 0 2 2 2 0 Calx-beta domain DCAF15_WD40 PF14939.6 PIK57237.1 - 8.6e-41 140.0 0.6 6.1e-37 127.4 0.7 3.2 1 1 1 2 2 2 2 DDB1-and CUL4-substrate receptor 15, WD repeat DUF4336 PF14234.6 PIK57237.1 - 0.055 12.6 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4336) Glyoxalase_2 PF12681.7 PIK57237.1 - 0.078 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase-like domain RVT_1 PF00078.27 PIK57239.1 - 1e-40 139.6 0.0 2.5e-34 118.7 0.0 2.4 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) Herpes_UL6 PF01763.16 PIK57240.1 - 0.0016 17.1 0.6 0.0016 17.1 0.6 1.0 1 0 0 1 1 1 1 Herpesvirus UL6 like ALMT PF11744.8 PIK57240.1 - 0.0027 16.6 1.8 0.0027 16.6 1.8 1.3 1 1 0 1 1 1 1 Aluminium activated malate transporter Seryl_tRNA_N PF02403.22 PIK57240.1 - 0.0046 17.2 0.9 0.0088 16.3 0.9 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Prefoldin_2 PF01920.20 PIK57240.1 - 0.0092 15.9 1.1 0.017 15.0 1.1 1.5 1 0 0 1 1 1 1 Prefoldin subunit DASH_Spc19 PF08287.11 PIK57240.1 - 0.011 15.6 2.2 0.011 15.6 2.2 1.5 1 1 1 2 2 2 0 Spc19 TBCC_N PF16752.5 PIK57240.1 - 0.017 15.6 2.7 0.019 15.4 1.3 1.7 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF1351 PF07083.11 PIK57240.1 - 0.023 14.5 0.9 0.03 14.1 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Prefoldin PF02996.17 PIK57240.1 - 0.023 14.6 0.6 0.042 13.8 0.6 1.4 1 0 0 1 1 1 0 Prefoldin subunit Apolipoprotein PF01442.18 PIK57240.1 - 0.041 13.8 0.2 0.056 13.3 0.2 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain BMFP PF04380.13 PIK57240.1 - 0.045 14.2 0.0 0.078 13.5 0.0 1.5 1 0 0 1 1 1 0 Membrane fusogenic activity Sipho_Gp157 PF05565.11 PIK57240.1 - 0.055 13.5 1.3 0.076 13.0 1.3 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 REV1_C PF16727.5 PIK57240.1 - 0.086 13.2 0.1 3.3 8.2 0.0 2.3 2 1 0 2 2 2 0 DNA repair protein REV1 C-terminal domain bZIP_1 PF00170.21 PIK57240.1 - 1.6 8.9 6.0 0.16 12.1 0.8 2.1 2 0 0 2 2 2 0 bZIP transcription factor zf-RING_UBOX PF13445.6 PIK57241.1 - 2.8e-09 36.9 3.5 2.8e-09 36.9 3.5 3.2 3 1 0 3 3 2 1 RING-type zinc-finger zf-B_box PF00643.24 PIK57241.1 - 6.8e-08 32.5 21.6 1.9e-07 31.1 4.7 5.1 5 1 0 5 5 5 2 B-box zinc finger zf-C3HC4 PF00097.25 PIK57241.1 - 7.3e-08 32.2 7.2 7.3e-08 32.2 7.2 3.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK57241.1 - 8.7e-07 29.0 8.8 8.7e-07 29.0 8.8 4.1 3 2 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK57241.1 - 4.9e-06 26.3 8.1 4.9e-06 26.3 8.1 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK57241.1 - 6.8e-05 22.7 6.9 6.8e-05 22.7 6.9 3.8 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK57241.1 - 0.0021 17.9 13.1 0.0021 17.9 13.1 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK57241.1 - 0.0045 17.3 11.1 0.0045 17.3 11.1 3.9 3 0 0 3 3 3 1 Ring finger domain FAM184 PF15665.5 PIK57241.1 - 0.083 12.7 28.0 0.25 11.1 28.0 1.7 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Apolipoprotein PF01442.18 PIK57241.1 - 0.19 11.6 16.0 0.31 10.9 16.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain tRNA-synt_1e PF01406.19 PIK57241.1 - 0.21 10.9 7.1 0.58 9.5 6.6 2.0 1 1 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain ALMT PF11744.8 PIK57241.1 - 1.2 7.9 15.9 1.9 7.3 15.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 PIK57241.1 - 1.8 7.9 16.0 2.7 7.3 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF885 PF05960.11 PIK57241.1 - 2.1 7.9 12.0 0.87 9.1 1.6 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) Sds3 PF08598.11 PIK57241.1 - 8.3 6.3 23.0 0.05 13.6 12.2 2.1 1 1 1 2 2 2 0 Sds3-like Xan_ur_permease PF00860.20 PIK57242.1 - 3.3e-76 256.5 30.2 4.5e-76 256.1 30.2 1.1 1 0 0 1 1 1 1 Permease family YfzA PF14118.6 PIK57242.1 - 0.63 10.5 3.8 2 8.8 3.8 1.8 1 0 0 1 1 1 0 YfzA-like protein Bap31 PF05529.12 PIK57242.1 - 1.3 8.9 3.1 4.9 7.0 0.1 3.0 3 0 0 3 3 3 0 Bap31/Bap29 transmembrane region SNARE PF05739.19 PIK57243.1 - 0.0013 18.7 0.2 0.0022 18.0 0.2 1.5 1 0 0 1 1 1 1 SNARE domain Ribosom_S12_S23 PF00164.25 PIK57244.1 - 3.2e-52 174.9 0.9 4.1e-52 174.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Syndecan PF01034.20 PIK57246.1 - 0.17 11.8 0.4 0.35 10.8 0.4 1.4 1 0 0 1 1 1 0 Syndecan domain Flavi_propep PF01570.17 PIK57246.1 - 0.46 10.5 2.1 1.2 9.1 2.1 1.8 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide Muskelin_N PF06588.11 PIK57247.1 - 1.3e-46 159.0 0.1 1.5e-46 158.8 0.1 1.0 1 0 0 1 1 1 1 Muskelin N-terminus F5_F8_type_C PF00754.25 PIK57247.1 - 0.0013 18.9 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain XRCC1_N PF01834.16 PIK57247.1 - 0.0063 16.5 0.1 0.0088 16.1 0.1 1.2 1 0 0 1 1 1 1 XRCC1 N terminal domain Kelch_3 PF13415.6 PIK57248.1 - 2.9e-25 88.0 3.2 8.3e-07 29.1 0.0 5.9 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK57248.1 - 4.9e-22 77.7 6.7 4.2e-06 26.7 0.0 6.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK57248.1 - 4.4e-17 61.7 8.9 0.0026 18.0 0.1 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 PIK57248.1 - 8e-16 57.4 15.5 0.0001 21.8 0.0 5.9 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 PIK57248.1 - 2.9e-15 55.9 3.2 0.056 13.4 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 PIK57248.1 - 7e-10 38.5 12.6 0.12 12.4 0.5 6.5 6 1 0 6 6 6 4 Kelch motif DUF2452 PF10504.9 PIK57248.1 - 0.02 14.4 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) LRR_8 PF13855.6 PIK57249.1 - 1.4e-17 63.2 17.6 1.1e-12 47.6 0.9 2.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK57249.1 - 8.5e-11 41.9 5.5 3.8e-05 24.0 0.1 2.9 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK57249.1 - 0.00012 22.2 10.6 10 7.1 0.0 5.3 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_5 PF13306.6 PIK57249.1 - 0.00083 19.3 0.1 0.0016 18.4 0.1 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK57249.1 - 0.0045 16.5 0.8 0.019 14.4 0.5 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRRNT PF01462.18 PIK57249.1 - 0.033 13.8 4.2 0.034 13.8 1.9 2.1 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 PIK57249.1 - 0.1 12.7 9.7 13 6.1 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich repeat SPACA9 PF15120.6 PIK57250.1 - 1e-08 35.1 0.0 1.5e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 SAT PF16073.5 PIK57250.1 - 0.17 11.6 0.0 4.1 7.1 0.0 2.6 3 0 0 3 3 3 0 Starter unit:ACP transacylase in aflatoxin biosynthesis NB-ARC PF00931.22 PIK57251.1 - 4.6e-30 104.6 0.0 8.4e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain APAF1_C PF17908.1 PIK57251.1 - 1.7e-29 102.6 0.0 3.2e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 APAF-1 helical domain WD40 PF00400.32 PIK57251.1 - 3.1e-20 72.1 16.6 4.1e-06 27.4 0.4 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat CARD PF00619.21 PIK57251.1 - 2.3e-09 37.2 0.0 4.7e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain ANAPC4_WD40 PF12894.7 PIK57251.1 - 1.8e-08 34.6 0.9 0.44 10.9 0.0 5.0 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 PIK57251.1 - 0.00022 21.6 0.0 0.00052 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK57251.1 - 0.0074 16.6 0.0 0.025 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain Ge1_WD40 PF16529.5 PIK57251.1 - 0.018 14.0 2.2 2.7 6.9 0.0 3.7 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2719 PF10891.8 PIK57251.1 - 0.027 14.3 0.1 0.079 12.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) AAA_33 PF13671.6 PIK57251.1 - 0.084 13.0 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 PIK57252.1 - 1.1e-08 35.6 3.9 8.3e-06 26.5 0.3 2.7 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57252.1 - 0.00048 20.4 0.0 0.0028 17.9 0.0 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2415 PF10313.9 PIK57252.1 - 0.043 13.7 0.0 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) HSP90 PF00183.18 PIK57253.1 - 2.6e-222 739.3 35.6 2.6e-222 739.3 35.6 1.6 1 1 1 2 2 2 1 Hsp90 protein HATPase_c PF02518.26 PIK57253.1 - 4.7e-13 49.6 0.1 1.1e-12 48.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 PIK57253.1 - 3.5e-11 43.1 0.2 1.1e-10 41.5 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CobT PF06213.12 PIK57253.1 - 9.1e-06 25.3 30.4 1.6e-05 24.4 12.7 2.5 2 0 0 2 2 2 2 Cobalamin biosynthesis protein CobT Ribosomal_L10 PF00466.20 PIK57253.1 - 0.056 13.6 1.3 4.8 7.4 0.1 3.0 2 0 0 2 2 2 0 Ribosomal protein L10 NOA36 PF06524.12 PIK57253.1 - 4.2 6.6 31.5 0.6 9.4 12.4 2.7 2 0 0 2 2 2 0 NOA36 protein pPIWI_RE_Y PF18156.1 PIK57254.1 - 0.07 13.6 0.2 0.22 11.9 0.2 1.8 1 0 0 1 1 1 0 pPIWI_RE three-gene island domain Y PDZ PF00595.24 PIK57255.1 - 0.00038 20.8 0.1 0.00055 20.2 0.1 1.3 1 0 0 1 1 1 1 PDZ domain zf-C3HC4_2 PF13923.6 PIK57256.1 - 1.1e-10 41.2 9.1 1.1e-10 41.2 9.1 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK57256.1 - 7.8e-09 35.4 6.9 7.8e-09 35.4 6.9 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK57256.1 - 5e-08 33.2 8.5 5e-08 33.2 8.5 3.2 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 PIK57256.1 - 7.6e-08 32.1 8.1 7.6e-08 32.1 8.1 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK57256.1 - 9.8e-07 28.5 5.0 9.8e-07 28.5 5.0 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK57256.1 - 1.8e-06 28.0 8.0 1.8e-06 28.0 8.0 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK57256.1 - 6.5e-06 25.9 8.0 2.1e-05 24.3 8.0 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK57256.1 - 2.3e-05 24.3 6.2 2.3e-05 24.3 6.2 2.7 3 1 0 3 3 2 1 zinc-RING finger domain zf-TRAF PF02176.18 PIK57256.1 - 0.0017 19.0 5.3 0.0017 19.0 5.3 3.0 1 1 1 2 2 2 1 TRAF-type zinc finger Sina PF03145.16 PIK57256.1 - 0.005 16.8 0.9 0.005 16.8 0.9 2.3 1 1 1 2 2 2 2 Seven in absentia protein family zf-RING_6 PF14835.6 PIK57256.1 - 0.0073 16.2 3.2 0.0073 16.2 3.2 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 PIK57256.1 - 0.032 14.5 7.7 0.032 14.5 7.7 3.4 3 2 1 4 4 4 0 RING-H2 zinc finger domain Dynamitin PF04912.14 PIK57256.1 - 0.032 13.6 2.5 0.049 13.0 2.5 1.1 1 0 0 1 1 1 0 Dynamitin zf-RING_11 PF17123.5 PIK57256.1 - 0.039 13.7 3.8 0.039 13.7 3.8 2.4 2 0 0 2 2 2 0 RING-like zinc finger U-box PF04564.15 PIK57256.1 - 0.067 13.4 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 U-box domain IBR PF01485.21 PIK57256.1 - 6.7 7.0 21.0 4.1 7.7 5.0 3.2 1 1 0 2 2 2 0 IBR domain, a half RING-finger domain SIP1 PF04938.12 PIK57257.1 - 3.3e-59 200.3 0.0 3.8e-59 200.0 0.0 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) ATP-gua_Ptrans PF00217.19 PIK57258.1 - 1.5e-234 772.8 0.0 5.6e-80 267.8 0.0 3.1 3 0 0 3 3 3 3 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 PIK57258.1 - 5.7e-89 292.5 0.1 6.4e-29 100.2 0.0 3.4 3 0 0 3 3 3 3 ATP:guanido phosphotransferase, N-terminal domain zf-RING_14 PF17978.1 PIK57258.1 - 0.00057 20.3 0.0 10 6.6 0.0 4.1 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain HsbA PF12296.8 PIK57258.1 - 0.025 15.0 0.2 9 6.8 0.0 3.2 3 0 0 3 3 3 0 Hydrophobic surface binding protein A P4Ha_N PF08336.11 PIK57258.1 - 0.063 13.3 0.5 17 5.5 0.0 3.0 3 0 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2740 PF10872.8 PIK57258.1 - 0.28 11.1 3.1 6.7 6.7 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2740) ATP-gua_Ptrans PF00217.19 PIK57259.1 - 2e-41 141.8 0.0 2.7e-41 141.4 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_Ptrans PF00217.19 PIK57260.1 - 2e-58 197.4 0.0 2.3e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain 7tm_1 PF00001.21 PIK57261.1 - 1.1e-10 41.3 15.8 1.4e-10 40.9 15.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_M20 PF01546.28 PIK57262.1 - 9.5e-34 116.9 0.0 1.5e-33 116.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 PIK57262.1 - 8.6e-14 51.4 0.0 1.5e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 PIK57262.1 - 3e-05 23.8 0.0 7.4e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 N_formyltrans_C PF18216.1 PIK57262.1 - 0.086 12.5 0.0 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 N-formyltransferase dimerization C-terminal domain VIT PF08487.10 PIK57263.1 - 8.4e-26 90.4 3.0 1.7e-25 89.4 3.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain ITI_HC_C PF06668.12 PIK57263.1 - 3.6e-22 78.9 0.1 6.6e-22 78.1 0.1 1.3 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA_3 PF13768.6 PIK57263.1 - 4.8e-17 62.3 0.0 7.7e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK57263.1 - 2.6e-16 60.4 0.0 4.9e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK57263.1 - 8.9e-10 39.2 0.0 2.4e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK57263.1 - 0.071 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein 7tm_2 PF00002.24 PIK57264.1 - 4.1e-28 98.3 16.7 6e-28 97.8 16.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK57264.1 - 1.3e-12 48.0 5.9 1.3e-12 48.0 5.9 2.5 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Gal-3-0_sulfotr PF06990.11 PIK57265.1 - 1.5e-12 47.2 0.3 1.8e-12 46.8 0.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK57265.1 - 0.0085 15.6 0.1 0.012 15.1 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain LRR_8 PF13855.6 PIK57266.1 - 2.9e-35 119.8 24.4 2e-14 53.1 0.2 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 PIK57266.1 - 1.4e-15 57.2 31.4 0.00025 21.4 2.4 6.2 4 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK57266.1 - 1.6e-12 47.5 0.5 2.7e-08 33.8 0.1 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK57266.1 - 1.4e-06 27.9 8.0 0.007 15.9 2.0 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK57266.1 - 7.1e-06 25.9 28.6 0.41 11.4 0.1 8.8 9 1 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK57266.1 - 0.25 11.5 26.1 0.49 10.6 0.2 7.0 8 0 0 8 8 8 0 Leucine Rich repeat LRR_4 PF12799.7 PIK57269.1 - 1e-11 44.8 7.1 2.2e-05 24.7 0.7 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57269.1 - 2e-11 43.5 8.1 6e-08 32.3 0.7 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 PIK57269.1 - 0.00052 20.2 11.6 0.92 10.3 0.0 5.0 5 1 0 5 5 4 1 Leucine Rich Repeat TMEM154 PF15102.6 PIK57269.1 - 0.0014 18.5 0.2 0.0014 18.5 0.2 1.6 2 0 0 2 2 1 1 TMEM154 protein family Endomucin PF07010.12 PIK57269.1 - 0.0099 15.9 1.3 0.015 15.3 1.3 1.2 1 0 0 1 1 1 1 Endomucin Myco_arth_vir_N PF09610.10 PIK57269.1 - 0.014 15.5 0.9 0.032 14.3 0.9 1.7 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) LRR_9 PF14580.6 PIK57269.1 - 0.023 14.2 1.5 0.38 10.2 0.5 1.9 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK57269.1 - 0.023 14.7 10.2 0.3 11.2 0.2 3.6 4 0 0 4 4 4 0 Leucine Rich repeat Glycophorin_A PF01102.18 PIK57269.1 - 0.029 14.6 0.1 0.029 14.6 0.1 1.9 2 0 0 2 2 2 0 Glycophorin A LRRC37AB_C PF14914.6 PIK57269.1 - 0.065 13.1 0.2 0.065 13.1 0.2 2.1 1 1 1 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Renin_r PF07850.14 PIK57269.1 - 0.12 13.0 0.1 0.26 11.9 0.1 1.6 1 0 0 1 1 1 0 Renin receptor-like protein RIFIN PF02009.16 PIK57269.1 - 0.27 11.1 0.0 0.27 11.1 0.0 1.7 2 0 0 2 2 1 0 Rifin DUF5383 PF17355.2 PIK57269.1 - 0.31 11.4 0.0 0.31 11.4 0.0 1.7 2 0 0 2 2 1 0 Family of unknown function (DUF5383) OATP PF03137.20 PIK57270.1 - 1.9e-46 158.5 8.5 2e-33 115.5 4.8 2.0 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK57270.1 - 9.4e-06 25.7 11.7 9.4e-06 25.7 11.7 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK57270.1 - 0.029 14.4 4.8 0.065 13.3 4.8 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain OATP PF03137.20 PIK57271.1 - 2.5e-147 491.5 12.5 3.1e-147 491.2 12.5 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK57271.1 - 7.3e-22 77.8 33.9 1.1e-18 67.3 26.9 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK57271.1 - 2.4e-07 30.8 9.8 5.1e-07 29.7 9.8 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.7 PIK57271.1 - 3.7e-06 26.1 9.5 0.0041 16.0 0.3 3.1 3 0 0 3 3 3 2 MFS_1 like family Kazal_1 PF00050.21 PIK57271.1 - 0.00072 19.5 4.2 0.002 18.1 4.2 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Trep_Strep PF09605.10 PIK57271.1 - 0.015 15.3 0.1 0.015 15.3 0.1 3.7 3 2 0 3 3 3 0 Hypothetical bacterial integral membrane protein (Trep_Strep) PUCC PF03209.15 PIK57271.1 - 3.4 6.6 14.5 1.5 7.8 0.0 3.8 4 0 0 4 4 4 0 PUCC protein OATP PF03137.20 PIK57272.1 - 3.9e-17 61.8 0.5 5.4e-17 61.3 0.5 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family OATP PF03137.20 PIK57273.1 - 1.4e-27 96.3 2.0 1.4e-27 96.2 2.0 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK57273.1 - 3.9e-05 23.7 3.6 7.8e-05 22.7 3.6 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Trep_Strep PF09605.10 PIK57273.1 - 0.00019 21.5 1.7 0.00082 19.4 0.3 2.1 2 0 0 2 2 2 1 Hypothetical bacterial integral membrane protein (Trep_Strep) MFS_1 PF07690.16 PIK57273.1 - 0.043 12.7 7.7 0.052 12.5 7.7 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Kazal_1 PF00050.21 PIK57273.1 - 0.12 12.4 5.0 0.27 11.3 5.0 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain OATP PF03137.20 PIK57274.1 - 5.2e-78 262.7 10.5 6.2e-78 262.4 10.5 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK57274.1 - 4.2e-13 49.0 19.9 8.5e-13 47.9 19.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Staphylcoagulse PF04022.12 PIK57274.1 - 0.28 10.8 3.2 0.67 9.5 3.2 1.6 1 0 0 1 1 1 0 Staphylocoagulase repeat DUF4271 PF14093.6 PIK57274.1 - 6.9 6.5 12.0 3.5 7.5 1.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) DENN PF02141.21 PIK57275.1 - 7.6e-47 159.7 1.9 9.5e-45 152.8 1.9 2.2 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 PIK57275.1 - 3e-10 40.7 0.9 3e-10 40.7 0.9 1.9 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 PIK57275.1 - 3.3e-08 33.4 3.7 7e-08 32.3 3.7 1.6 1 0 0 1 1 1 1 dDENN domain Amino_oxidase PF01593.24 PIK57276.1 - 1.2e-15 57.8 0.0 1.5e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Amino_oxidase PF01593.24 PIK57277.1 - 2.8e-38 132.4 0.0 3.5e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK57277.1 - 1e-09 38.5 0.1 2.1e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK57277.1 - 1.1e-08 35.1 0.2 3.3e-05 23.6 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 PIK57277.1 - 1.2e-06 27.9 1.0 0.0026 16.9 0.4 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.17 PIK57277.1 - 1.2e-06 28.0 0.5 2.9e-06 26.7 0.5 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 PIK57277.1 - 4.6e-06 26.1 0.2 7.1e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK57277.1 - 9.4e-06 25.0 0.8 1.7e-05 24.1 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 PIK57277.1 - 0.00012 21.5 1.9 0.2 10.9 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 PIK57277.1 - 0.00014 21.1 1.8 0.00094 18.4 0.2 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 PIK57277.1 - 0.00023 20.7 0.2 0.00037 20.0 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 PIK57277.1 - 0.00026 19.8 1.0 0.0047 15.7 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 PIK57277.1 - 0.0027 18.2 1.2 0.068 13.7 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK57277.1 - 0.0034 17.4 0.8 0.18 11.8 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 PIK57278.1 - 9.7e-61 206.3 0.2 1.8e-60 205.4 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.21 PIK57278.1 - 1.6e-44 152.2 0.0 1.9e-22 79.9 0.0 2.2 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 PIK57278.1 - 9.7e-19 67.5 0.3 1.9e-18 66.5 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 PIK57278.1 - 6e-09 35.7 0.0 2.1e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain Thi4 PF01946.17 PIK57278.1 - 0.0059 15.9 0.2 0.02 14.2 0.1 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 PIK57278.1 - 0.01 15.1 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK57278.1 - 0.021 14.1 0.1 0.052 12.8 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 PIK57278.1 - 0.033 13.1 0.1 0.22 10.3 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_3 PF01494.19 PIK57278.1 - 0.075 12.3 0.3 0.35 10.1 0.2 2.1 3 0 0 3 3 3 0 FAD binding domain SoxG PF04268.12 PIK57278.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family ApbA PF02558.16 PIK57278.1 - 0.16 11.6 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UPF0184 PF03670.13 PIK57279.1 - 1.2e-09 38.4 4.4 1.5e-09 38.1 4.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) HALZ PF02183.18 PIK57279.1 - 0.033 14.4 0.6 0.051 13.8 0.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper CLZ PF16526.5 PIK57279.1 - 0.042 14.2 0.5 0.071 13.5 0.1 1.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DEAD PF00270.29 PIK57280.1 - 1.3e-38 132.5 0.4 2.7e-38 131.5 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK57280.1 - 2.7e-25 88.9 0.3 4.8e-23 81.6 0.1 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 PIK57280.1 - 1.3e-07 31.7 0.0 2.5e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 PIK57280.1 - 0.015 14.7 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Acyl-CoA_dh_1 PF00441.24 PIK57281.1 - 4.3e-40 137.4 0.5 6.3e-40 136.8 0.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK57281.1 - 1.1e-27 97.0 0.1 2.1e-27 96.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK57281.1 - 1.5e-21 77.1 0.7 2.6e-21 76.3 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK57281.1 - 1e-13 51.3 0.1 2.1e-13 50.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Laminin_G_3 PF13385.6 PIK57282.1 - 0.036 14.2 0.0 0.08 13.1 0.0 1.6 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_3 PF13385.6 PIK57283.1 - 8.9e-10 38.9 0.0 1.6e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sushi PF00084.20 PIK57283.1 - 1.8e-05 25.2 26.9 0.011 16.3 0.6 5.9 5 1 0 5 5 5 2 Sushi repeat (SCR repeat) Notch PF00066.17 PIK57283.1 - 2.6e-05 24.6 4.1 2.6e-05 24.6 4.1 5.6 5 0 0 5 5 4 2 LNR domain Peptidase_M43 PF05572.13 PIK57283.1 - 0.00016 21.6 0.1 0.00065 19.6 0.1 2.0 1 1 0 1 1 1 1 Pregnancy-associated plasma protein-A Peptidase_M57 PF12388.8 PIK57283.1 - 0.0019 17.9 0.7 0.0041 16.8 0.7 1.5 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.6 PIK57283.1 - 0.0027 17.9 0.9 0.0062 16.7 0.9 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK57283.1 - 0.0038 17.7 0.1 0.0096 16.4 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK57283.1 - 0.011 15.4 0.7 0.05 13.2 0.4 2.2 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M11 PF05548.11 PIK57283.1 - 0.013 14.6 0.2 0.03 13.5 0.2 1.5 1 0 0 1 1 1 0 Gametolysin peptidase M11 Astacin PF01400.24 PIK57283.1 - 0.018 14.7 1.1 0.039 13.6 1.1 1.5 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 PIK57283.1 - 0.027 14.3 0.2 0.049 13.5 0.2 1.4 1 0 0 1 1 1 0 Matrixin Reprolysin PF01421.19 PIK57283.1 - 0.027 14.4 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.9 PIK57283.1 - 0.076 12.0 1.1 0.13 11.2 1.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Pkinase PF00069.25 PIK57284.1 - 1.2e-46 159.3 0.0 2.7e-46 158.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57284.1 - 1e-42 146.3 0.0 1.9e-31 109.3 0.0 2.0 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 PIK57284.1 - 6.3e-06 26.3 0.0 0.029 14.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK57284.1 - 2.6e-05 23.7 0.0 4.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK57284.1 - 0.00022 20.1 0.0 0.00054 18.9 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase B2 PF11473.8 PIK57284.1 - 0.072 12.9 0.1 0.38 10.6 0.0 2.2 3 0 0 3 3 3 0 RNA binding protein B2 AhpC-TSA PF00578.21 PIK57285.1 - 7.8e-24 84.0 0.0 1e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 PIK57285.1 - 3.9e-09 36.2 0.2 6.9e-09 35.4 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 PIK57285.1 - 2.6e-07 30.5 0.0 3.3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 PIK57285.1 - 0.00074 19.6 0.0 0.0017 18.5 0.0 1.5 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme BAT2_N PF07001.11 PIK57289.1 - 2e-23 83.8 13.3 2e-23 83.8 13.3 1.6 2 0 0 2 2 2 1 BAT2 N-terminus ADK PF00406.22 PIK57290.1 - 1e-41 142.5 0.0 1.7e-33 115.9 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 PIK57290.1 - 2.5e-20 73.3 0.0 1.6e-14 54.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 PIK57290.1 - 7.1e-07 29.8 0.0 0.02 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 PIK57290.1 - 2.8e-05 24.5 0.8 0.081 13.2 0.0 3.4 3 0 0 3 3 3 2 Hydin Adenylate kinase-like domain Choline_transpo PF04515.12 PIK57291.1 - 6.3e-98 328.0 38.2 6.3e-98 328.0 38.2 2.6 3 0 0 3 3 3 1 Plasma-membrane choline transporter ECR1_N PF14382.6 PIK57292.1 - 1.2e-16 60.2 0.2 2.2e-16 59.4 0.2 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 PIK57292.1 - 0.0014 18.9 0.1 0.0031 17.8 0.1 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 PIK57292.1 - 0.065 13.8 0.5 11 6.7 0.0 2.4 1 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 NPDC1 PF06809.11 PIK57294.1 - 4.3e-24 85.2 0.1 5e-24 85.0 0.1 1.1 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) Shisa PF13908.6 PIK57294.1 - 0.023 15.0 0.0 0.033 14.5 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Orthoreo_P10 PF07204.11 PIK57294.1 - 0.13 12.3 0.3 0.23 11.4 0.3 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Zip PF02535.22 PIK57294.1 - 0.13 11.5 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Fe-S_biosyn PF01521.20 PIK57295.1 - 2.1e-16 60.1 0.1 2.2e-16 60.0 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Torsin PF06309.11 PIK57297.1 - 3.8e-40 136.9 0.4 6.6e-40 136.1 0.4 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.29 PIK57297.1 - 0.00032 21.1 0.0 0.00059 20.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK57297.1 - 0.0035 17.3 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 PIK57297.1 - 0.019 14.9 0.2 0.066 13.2 0.2 1.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_2 PF07724.14 PIK57297.1 - 0.034 14.3 0.0 0.2 11.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.18 PIK57297.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 PIK57297.1 - 0.079 13.2 0.4 1.9 8.8 0.1 2.7 2 1 0 2 2 2 0 AAA domain CobA_CobO_BtuR PF02572.15 PIK57297.1 - 0.15 12.3 0.0 18 5.5 0.0 2.2 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP CC2-LZ PF16516.5 PIK57298.1 - 2.4e-05 24.6 3.9 2.4e-05 24.6 3.9 5.6 2 2 4 6 6 6 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YabA PF06156.13 PIK57298.1 - 2 9.1 44.6 0.19 12.3 10.6 5.1 3 2 1 4 4 4 0 Initiation control protein YabA GST_C_3 PF14497.6 PIK57299.1 - 7e-15 55.0 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK57299.1 - 2.8e-09 37.2 0.0 6.5e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK57299.1 - 3.8e-05 23.8 0.0 7.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK57299.1 - 0.0066 16.4 0.0 0.0099 15.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK57299.1 - 0.064 13.7 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Calx-beta PF03160.14 PIK57300.1 - 6e-25 87.3 28.2 5e-07 29.8 0.1 5.2 5 0 0 5 5 5 4 Calx-beta domain EGF_CA PF07645.15 PIK57300.1 - 9.1e-15 54.6 79.3 1.4e-07 31.6 5.8 7.9 7 1 0 7 7 7 5 Calcium-binding EGF domain cEGF PF12662.7 PIK57300.1 - 6.7e-06 25.9 42.3 0.0017 18.3 2.2 7.5 6 0 0 6 6 6 4 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK57300.1 - 0.00023 21.4 58.4 0.08 13.2 2.4 7.0 3 2 3 6 6 6 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK57300.1 - 0.0058 16.9 66.6 0.023 15.0 6.8 8.5 8 0 0 8 8 8 4 EGF-like domain EGF_3 PF12947.7 PIK57300.1 - 0.017 15.3 54.8 0.048 13.9 1.0 7.0 7 1 0 7 7 7 0 EGF domain hEGF PF12661.7 PIK57300.1 - 0.027 15.1 54.8 0.11 13.2 5.6 8.0 7 0 0 7 7 7 0 Human growth factor-like EGF SEA PF01390.20 PIK57300.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 SEA domain KRTAP PF11759.8 PIK57301.1 - 0.0025 18.3 60.3 1.8e+04 -18.4 60.3 3.5 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 PIK57301.1 - 0.075 13.2 66.6 1.8e+04 -17.9 66.6 3.1 1 1 0 1 1 1 0 Keratin type II head Calx-beta PF03160.14 PIK57302.1 - 2.6e-07 30.7 6.5 2.6e-06 27.5 1.2 2.8 2 0 0 2 2 2 2 Calx-beta domain Tim17 PF02466.19 PIK57302.1 - 0.11 12.8 17.3 1.8e+04 -4.9 17.3 5.5 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Calx-beta PF03160.14 PIK57303.1 - 1e-10 41.7 5.1 5.5e-06 26.5 0.4 2.6 3 0 0 3 3 3 2 Calx-beta domain GTP_EFTU PF00009.27 PIK57304.1 - 2.9e-57 193.4 0.0 3.5e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK57304.1 - 0.00052 20.1 0.0 0.0013 18.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK57304.1 - 0.026 14.0 0.0 0.061 12.7 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 PIK57304.1 - 0.05 12.8 0.1 0.26 10.4 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Ras PF00071.22 PIK57304.1 - 0.057 13.0 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Ras family Roc PF08477.13 PIK57304.1 - 0.06 13.6 0.0 0.76 10.0 0.0 2.2 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK57304.1 - 0.071 13.0 0.8 0.28 11.1 0.1 2.2 2 1 0 3 3 3 0 RsgA GTPase 30K_MP_C_Ter PF11330.8 PIK57304.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins DUF1387 PF07139.11 PIK57305.1 - 0.28 10.9 22.8 0.37 10.5 22.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF3824 PF12868.7 PIK57305.1 - 2.3 8.9 9.3 1.4 9.5 0.1 2.4 2 1 0 2 2 2 0 Domain of unknwon function (DUF3824) Macoilin PF09726.9 PIK57305.1 - 6 5.3 20.1 6.7 5.1 20.1 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 PIK57305.1 - 9.6 3.2 17.2 12 2.9 17.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MFS_1 PF07690.16 PIK57306.1 - 4e-37 128.0 52.6 3.3e-24 85.5 21.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK57306.1 - 1e-08 34.5 33.0 3.8e-05 22.7 3.3 4.2 3 1 1 4 4 4 4 MFS_1 like family GCOM2 PF15328.6 PIK57307.1 - 1.6e-15 58.1 4.1 2.3e-15 57.5 4.1 1.4 1 1 0 1 1 1 1 Putative GRINL1B complex locus protein 2 NICE-3 PF07406.11 PIK57308.1 - 4.2e-49 167.0 0.3 6.6e-49 166.3 0.3 1.2 1 0 0 1 1 1 1 NICE-3 protein Use1 PF09753.9 PIK57308.1 - 0.33 10.6 3.5 0.62 9.7 3.5 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 PEX11 PF05648.14 PIK57309.1 - 4.1e-46 157.2 0.4 4.6e-46 157.1 0.4 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Acid_phosphat_B PF03767.14 PIK57309.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) MoaE PF02391.17 PIK57310.1 - 1e-40 138.6 0.6 2.4e-40 137.3 0.1 1.7 2 0 0 2 2 2 1 MoaE protein ThiS PF02597.20 PIK57310.1 - 1.5e-07 31.9 0.0 3.1e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 ThiS family NHL PF01436.21 PIK57311.1 - 9.3e-18 63.3 11.8 4.8e-06 26.3 0.5 5.2 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 PIK57311.1 - 6e-07 29.3 0.1 0.055 13.0 0.0 3.9 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 PIK57311.1 - 0.0083 15.3 0.0 0.049 12.8 0.0 1.9 2 0 0 2 2 2 1 6-bladed beta-propeller PQQ PF01011.21 PIK57311.1 - 0.012 15.5 0.1 6.1 7.0 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat Cu2_monoox_C PF03712.15 PIK57312.1 - 2.8e-34 117.9 0.1 3.9e-34 117.4 0.1 1.2 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 PIK57312.1 - 2e-20 73.3 0.1 2.2e-19 70.0 0.0 2.1 2 0 0 2 2 2 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain TRAP_beta PF05753.14 PIK57313.1 - 6.2e-62 208.1 0.0 7.8e-62 207.8 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) CARDB PF07705.11 PIK57313.1 - 0.06 13.6 0.1 0.084 13.1 0.1 1.3 1 0 0 1 1 1 0 CARDB I-set PF07679.16 PIK57314.1 - 6.3e-29 99.9 2.9 5e-12 45.7 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK57314.1 - 3.9e-26 91.5 2.2 1e-09 38.9 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK57314.1 - 5.5e-20 71.3 3.9 1.6e-06 28.2 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK57314.1 - 3.3e-17 62.6 4.6 1.9e-05 24.9 0.0 3.4 2 1 1 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK57314.1 - 1.7e-07 31.3 8.2 0.0019 18.4 0.1 5.4 3 3 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK57314.1 - 1.2e-05 25.6 3.2 0.019 15.3 0.0 4.0 4 1 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.11 PIK57314.1 - 3e-05 24.0 0.6 0.3 11.1 0.0 3.4 2 1 1 3 3 3 1 CD47 immunoglobulin-like domain Wzt_C PF14524.6 PIK57314.1 - 0.002 18.2 0.1 0.013 15.5 0.1 2.4 1 1 0 1 1 1 1 Wzt C-terminal domain Ig_6 PF18452.1 PIK57314.1 - 0.027 14.0 0.0 0.48 10.0 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Izumo-Ig PF16706.5 PIK57314.1 - 0.034 14.2 0.0 0.34 11.0 0.0 2.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK57314.1 - 0.037 14.4 0.4 2.6 8.5 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain DUF3642 PF12182.8 PIK57314.1 - 0.087 13.1 6.3 1.3 9.4 0.8 2.9 3 0 0 3 3 3 0 Bacterial lipoprotein Ion_trans PF00520.31 PIK57315.1 - 2.9e-27 95.5 17.8 3.9e-27 95.0 17.8 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.10 PIK57315.1 - 6.5e-18 64.1 0.1 1.3e-17 63.1 0.1 1.6 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.29 PIK57315.1 - 8.5e-18 64.2 0.1 1.7e-17 63.2 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK57315.1 - 0.0048 16.8 1.0 0.011 15.7 0.1 2.2 2 0 0 2 2 2 1 Ion channel Osw5 PF17062.5 PIK57315.1 - 0.03 14.4 1.4 0.11 12.6 1.4 1.9 1 0 0 1 1 1 0 Outer spore wall 5 LIM PF00412.22 PIK57316.1 - 1.8e-23 82.5 27.8 1.2e-12 47.9 10.8 2.0 2 0 0 2 2 2 2 LIM domain C1_4 PF07975.12 PIK57316.1 - 0.0024 18.1 5.2 0.0024 18.1 5.2 2.6 2 1 0 2 2 2 1 TFIIH C1-like domain NPV_P10 PF05531.12 PIK57318.1 - 0.19 12.2 1.4 0.65 10.5 0.1 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Cyclin_N PF00134.23 PIK57319.1 - 5.5e-41 139.3 2.6 5.5e-41 139.3 2.6 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK57319.1 - 9.9e-37 125.7 2.2 1.6e-36 125.0 0.8 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Aldedh PF00171.22 PIK57320.1 - 5.6e-38 130.6 0.2 6.7e-38 130.4 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 PIK57321.1 - 5.6e-25 87.8 0.0 6.7e-25 87.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Arrestin_N PF00339.29 PIK57322.1 - 1.2e-34 119.5 0.0 1.7e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 PIK57322.1 - 1.1e-26 93.8 0.0 4.9e-21 75.6 0.0 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 PIK57322.1 - 0.0018 17.4 0.0 0.003 16.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Pro_isomerase PF00160.21 PIK57323.1 - 3.3e-44 150.9 0.0 4e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TSP_1 PF00090.19 PIK57324.1 - 4.2e-20 71.7 60.1 1.6e-06 28.2 7.5 6.1 6 0 0 6 6 6 4 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 PIK57324.1 - 5e-12 45.9 0.2 8.7e-12 45.1 0.2 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 PIK57324.1 - 7.8e-12 45.5 9.8 5.3e-10 39.5 9.8 2.3 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 PIK57324.1 - 2.2e-10 41.0 4.0 2.2e-10 41.0 4.0 2.4 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK57324.1 - 1.1e-07 32.3 1.3 3.2e-07 30.9 1.3 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK57324.1 - 2.6e-07 30.7 3.3 4.2e-07 30.1 0.8 2.5 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 PIK57324.1 - 0.0036 18.0 5.2 0.022 15.5 5.2 2.5 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Reprolysin_4 PF13583.6 PIK57324.1 - 0.0071 16.0 2.6 0.022 14.4 2.6 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK57324.1 - 0.042 13.7 1.1 0.087 12.7 0.1 2.1 3 0 0 3 3 3 0 Matrixin zinc_ribbon_2 PF13240.6 PIK57324.1 - 0.49 10.2 4.0 4.6 7.1 0.0 3.7 3 0 0 3 3 3 0 zinc-ribbon domain AAA_18 PF13238.6 PIK57325.1 - 9.1e-13 48.9 0.1 1.7e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain Ribosomal_S3Ae PF01015.18 PIK57325.1 - 0.13 11.8 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal S3Ae family 7tm_1 PF00001.21 PIK57327.1 - 2e-42 145.4 12.9 2e-42 145.4 12.9 1.4 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK57327.1 - 4.1e-09 36.2 14.0 5.6e-09 35.8 14.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK57327.1 - 0.0019 17.9 18.9 0.006 16.3 17.3 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1907 PF08925.11 PIK57327.1 - 0.098 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) CAS_CSE1 PF03378.15 PIK57328.1 - 0.0034 15.9 0.1 0.0051 15.4 0.1 1.2 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus SeqA_N PF17206.3 PIK57328.1 - 0.23 10.8 2.1 0.52 9.7 0.0 2.6 3 0 0 3 3 3 0 SeqA protein N-terminal domain Homeodomain PF00046.29 PIK57329.1 - 2.3e-15 56.2 1.5 4.4e-15 55.3 0.9 1.8 2 0 0 2 2 2 1 Homeodomain DUF3528 PF12045.8 PIK57329.1 - 0.093 13.4 0.1 0.16 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3528) Homeodomain PF00046.29 PIK57330.1 - 7.8e-15 54.5 0.5 2e-14 53.1 0.5 1.7 1 0 0 1 1 1 1 Homeodomain FAM176 PF14851.6 PIK57330.1 - 0.018 14.7 3.1 0.022 14.4 3.1 1.2 1 0 0 1 1 1 0 FAM176 family ORC6 PF05460.13 PIK57330.1 - 0.052 12.8 5.7 0.056 12.7 5.7 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Nucleo_P87 PF07267.11 PIK57330.1 - 0.15 10.9 5.5 0.16 10.8 5.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 PIK57330.1 - 0.8 7.9 7.7 0.85 7.8 7.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1764 PF08576.10 PIK57330.1 - 1.5 9.8 8.9 4.3 8.3 8.9 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 PIK57330.1 - 3 6.5 4.8 3.2 6.4 4.8 1.1 1 0 0 1 1 1 0 Presenilin IQ PF00612.27 PIK57331.1 - 0.00058 19.4 0.1 0.0014 18.2 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ldl_recept_a PF00057.18 PIK57332.1 - 4.2e-23 81.3 34.8 7.5e-12 45.3 12.5 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF4407 PF14362.6 PIK57332.1 - 0.003 17.0 6.8 0.0038 16.6 6.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 PIK57332.1 - 0.03 14.4 5.3 0.039 14.0 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 PIK57332.1 - 0.12 11.5 1.8 0.14 11.4 1.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter O-antigen_lig PF13425.6 PIK57332.1 - 4.8 5.9 7.4 6.3 5.5 7.4 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sugar_tr PF00083.24 PIK57333.1 - 2.4e-25 89.3 8.7 2.4e-25 89.3 8.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK57333.1 - 1.4e-22 80.1 20.5 1.4e-22 80.1 20.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily EamA PF00892.20 PIK57334.1 - 1.2e-17 64.3 33.9 3.5e-12 46.7 7.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family Spaetzle PF16077.5 PIK57334.1 - 0.092 13.3 0.1 22 5.7 0.0 2.4 2 0 0 2 2 2 0 Spaetzle DNA_pol_delta_4 PF04081.13 PIK57335.1 - 8.2e-19 68.2 0.1 8.2e-19 68.2 0.1 3.2 2 1 0 3 3 3 1 DNA polymerase delta, subunit 4 SET PF00856.28 PIK57335.1 - 8.5e-06 26.3 1.4 0.00045 20.6 0.0 2.6 2 1 0 2 2 2 1 SET domain adh_short PF00106.25 PIK57337.1 - 1.5e-36 125.7 0.3 1.9e-36 125.4 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK57337.1 - 3.3e-27 95.5 0.1 4.4e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK57337.1 - 1.4e-06 28.4 0.1 2.2e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK57337.1 - 0.00013 21.5 0.1 0.00018 21.1 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 PIK57337.1 - 0.00082 18.6 0.0 0.001 18.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK57337.1 - 0.006 16.0 0.0 0.0076 15.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 PIK57337.1 - 0.031 13.3 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_transf_29 PF00777.18 PIK57338.1 - 2.7e-36 125.4 4.4 2.7e-22 79.5 2.6 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) PRELI PF04707.14 PIK57339.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 PRELI-like family UCH PF00443.29 PIK57341.1 - 2.9e-23 82.7 0.0 6.4e-23 81.6 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF4807 PF16065.5 PIK57342.1 - 1.8e-35 121.3 0.0 3.2e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4807) Thioredoxin PF00085.20 PIK57343.1 - 4.5e-13 49.1 0.0 7.4e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OmdA PF13376.6 PIK57344.1 - 0.014 15.4 1.0 0.039 14.0 1.0 1.7 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated GST_C_3 PF14497.6 PIK57345.1 - 8.8e-17 61.1 0.3 1.2e-16 60.7 0.3 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK57345.1 - 4.1e-06 26.9 0.1 6.1e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK57345.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK57345.1 - 0.065 13.6 0.1 1.6 9.1 0.0 2.5 3 0 0 3 3 3 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 PIK57345.1 - 0.12 13.0 0.0 0.15 12.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 PIK57345.1 - 0.13 13.0 0.0 0.35 11.6 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain zf-CCHC PF00098.23 PIK57346.1 - 0.00026 20.9 3.2 0.00026 20.9 3.2 2.9 3 0 0 3 3 3 1 Zinc knuckle CPSF_A PF03178.15 PIK57347.1 - 3.8e-36 125.0 0.0 6.3e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 CPSF A subunit region MLVIN_C PF18697.1 PIK57347.1 - 0.099 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Y_phosphatase PF00102.27 PIK57348.1 - 6.1e-26 91.4 0.2 6.6e-26 91.3 0.2 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RVT_2 PF07727.14 PIK57349.1 - 7.1e-24 84.8 0.6 1.3e-23 83.9 0.6 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK57350.1 - 9.7e-35 120.1 0.2 2.1e-34 119.0 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Y_phosphatase PF00102.27 PIK57350.1 - 1.5e-07 31.3 0.0 2.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Exo_endo_phos_2 PF14529.6 PIK57350.1 - 9.1e-06 25.5 0.1 3e-05 23.8 0.1 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Y_phosphatase PF00102.27 PIK57351.1 - 1.5e-64 217.8 3.4 3.3e-35 121.8 1.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 PIK57351.1 - 4.2e-11 43.0 4.4 1.3e-05 25.4 0.6 2.8 2 0 0 2 2 2 2 Fibronectin type III domain DSPc PF00782.20 PIK57351.1 - 0.00071 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Pur_ac_phosph_N PF16656.5 PIK57351.1 - 0.00093 19.7 4.7 0.075 13.6 1.5 3.0 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain DUF4448 PF14610.6 PIK57351.1 - 0.0048 16.7 0.0 0.022 14.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 PIK57351.1 - 0.03 14.2 0.1 0.1 12.5 0.1 1.9 1 0 0 1 1 1 0 TMEM154 protein family GPI-anchored PF10342.9 PIK57351.1 - 0.17 12.7 4.9 0.29 11.9 1.5 2.9 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family TSP_1 PF00090.19 PIK57353.1 - 7.5e-08 32.5 10.5 1.2e-07 31.8 10.5 1.3 1 0 0 1 1 1 1 Thrombospondin type 1 domain Lectin_C PF00059.21 PIK57353.1 - 0.0052 17.5 0.1 0.014 16.1 0.1 1.8 1 0 0 1 1 1 1 Lectin C-type domain LSM PF01423.22 PIK57354.1 - 1.9e-20 72.3 0.3 2.4e-20 72.0 0.3 1.1 1 0 0 1 1 1 1 LSM domain TH1 PF04858.13 PIK57355.1 - 3.8e-78 263.6 0.0 4.4e-78 263.4 0.0 1.0 1 0 0 1 1 1 1 TH1 protein TH1 PF04858.13 PIK57357.1 - 2.5e-91 307.1 6.1 1e-82 278.7 2.9 2.0 1 1 1 2 2 2 2 TH1 protein zf-H2C2_2 PF13465.6 PIK57359.1 - 9.9e-31 104.8 88.8 9.5e-08 32.1 6.8 12.1 13 0 0 13 13 13 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK57359.1 - 1.9e-27 94.1 98.8 0.00044 20.6 1.5 12.2 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK57359.1 - 3.6e-18 64.7 89.0 0.012 16.4 2.1 12.3 12 0 0 12 12 12 9 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK57359.1 - 1.5e-08 34.2 22.8 2.3e-05 24.0 0.7 11.4 13 0 0 13 13 13 5 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 PIK57359.1 - 0.0016 18.7 49.7 0.0057 16.9 4.9 6.0 1 1 5 6 6 6 5 C2H2-type zinc ribbon zf-Di19 PF05605.12 PIK57359.1 - 0.0029 17.9 58.5 0.0058 16.9 5.7 6.7 4 2 3 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK57359.1 - 0.052 13.6 0.5 0.052 13.6 0.5 9.5 12 2 0 12 12 12 0 C2H2-type zinc finger zf-GRF PF06839.12 PIK57359.1 - 3.2 7.9 10.6 27 4.9 5.6 3.8 1 1 1 2 2 2 0 GRF zinc finger zf-C2H2_4 PF13894.6 PIK57360.1 - 3.3e-15 55.5 94.5 0.081 13.8 0.2 13.8 13 0 0 13 13 13 10 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK57360.1 - 4.5e-11 42.6 93.9 0.023 15.1 1.9 13.2 13 0 0 13 13 13 8 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK57360.1 - 3.3e-07 29.9 8.1 0.00026 20.7 1.0 11.4 12 0 0 12 12 12 5 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 PIK57360.1 - 8.9e-07 29.1 91.9 0.0013 19.1 1.2 13.7 14 1 0 14 14 14 7 Zinc-finger double domain AKAP95 PF04988.12 PIK57360.1 - 0.0067 16.7 1.5 0.0067 16.7 1.5 8.2 8 2 1 9 9 9 3 A-kinase anchoring protein 95 (AKAP95) zf_C2H2_ZHX PF18387.1 PIK57360.1 - 0.037 13.7 0.1 0.037 13.7 0.1 8.6 7 2 3 10 10 10 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF1011 PF06237.12 PIK57362.1 - 2.9e-29 101.3 8.3 2.9e-29 101.3 8.3 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) DUF1011 PF06237.12 PIK57363.1 - 0.002 18.4 1.0 0.011 16.1 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) GpcrRhopsn4 PF10192.9 PIK57363.1 - 0.029 13.8 0.3 0.031 13.7 0.3 1.2 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain DPM3 PF08285.11 PIK57363.1 - 0.038 14.2 0.9 0.038 14.2 0.9 2.0 1 1 1 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF1011 PF06237.12 PIK57364.1 - 3.3e-12 46.6 2.2 3.3e-12 46.6 2.2 3.4 3 1 0 3 3 3 2 Protein of unknown function (DUF1011) 2-Hacid_dh_C PF02826.19 PIK57365.1 - 5e-37 127.0 0.0 6.2e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Myosin_head PF00063.21 PIK57366.1 - 1.8e-176 588.3 2.4 2.6e-176 587.8 2.4 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 PIK57366.1 - 7.4e-39 133.4 7.9 9.6e-39 133.0 6.5 1.9 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 PIK57366.1 - 1.7e-09 36.6 9.5 0.039 13.7 0.1 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif DUF3874 PF12990.7 PIK57366.1 - 0.06 13.7 0.1 3.4 8.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknonw function from B. Theta Gene description (DUF3874) LRR_8 PF13855.6 PIK57367.1 - 1.7e-21 75.7 28.5 1.5e-08 34.3 5.8 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK57367.1 - 1.1e-16 60.6 23.3 1.7e-06 28.3 5.5 5.0 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK57367.1 - 3.3e-09 36.0 19.5 3.7 8.5 0.9 7.5 7 0 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.6 PIK57367.1 - 9.7e-05 22.1 24.6 5.1 7.4 0.4 7.6 8 0 0 8 8 8 3 Leucine Rich repeat RsmF_methylt_CI PF17126.5 PIK57367.1 - 0.013 15.5 0.1 2.8 8.0 0.0 3.8 2 2 3 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain bZIP_1 PF00170.21 PIK57368.1 - 1.2e-13 50.9 9.2 2.8e-13 49.7 9.2 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK57368.1 - 5.9e-06 26.3 8.6 5.9e-06 26.3 8.6 2.2 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 PIK57368.1 - 0.0074 16.8 3.2 0.0074 16.8 3.2 2.6 3 0 0 3 3 3 1 bZIP Maf transcription factor DUF1353 PF07087.11 PIK57368.1 - 0.071 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) zf-C2H2_4 PF13894.6 PIK57368.1 - 0.79 10.7 3.1 1.5 9.8 3.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger ZU5 PF00791.20 PIK57369.1 - 7.3e-33 112.8 0.0 1.4e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain PDZ PF00595.24 PIK57370.1 - 2.5e-25 88.6 1.2 9.6e-15 54.7 0.0 3.4 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 PIK57370.1 - 6.5e-17 61.1 6.7 7.2e-08 32.2 0.2 3.0 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 PIK57370.1 - 1.2e-11 44.8 0.2 6.4e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 PDZ domain BRCT PF00533.26 PIK57371.1 - 2.1e-39 133.7 0.1 2e-12 47.3 0.0 4.5 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 PIK57371.1 - 2.4e-29 101.1 0.5 3e-14 52.7 0.1 3.8 3 1 0 3 3 3 3 twin BRCT domain BRCT_2 PF16589.5 PIK57371.1 - 3.5e-20 72.2 0.0 4.7e-07 30.1 0.0 4.1 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK57371.1 - 7.1e-08 32.3 0.0 4.1e-06 26.6 0.0 3.4 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 PIK57371.1 - 1.4e-07 31.7 0.1 0.027 14.8 0.1 3.9 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 PIK57371.1 - 0.00013 22.0 0.0 0.061 13.4 0.0 3.7 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 PIK57372.1 - 1.5e-37 127.4 3.7 2.9e-20 72.0 0.3 4.4 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 PIK57372.1 - 9e-37 125.3 3.9 1.7e-13 50.7 0.1 5.1 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK57372.1 - 7.9e-16 58.2 3.5 0.00017 21.9 0.0 3.7 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 PIK57372.1 - 2.9e-08 33.9 0.2 0.063 13.6 0.0 3.4 3 0 0 3 3 3 3 DNA ligase 3 BRCT domain FAIM1 PF06905.13 PIK57373.1 - 1.3e-58 197.5 0.1 4.2e-44 150.3 0.0 2.0 1 1 1 2 2 2 2 Fas apoptotic inhibitory molecule (FAIM1) COesterase PF00135.28 PIK57374.1 - 2.4e-111 373.1 0.2 1.8e-74 251.5 0.0 2.7 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK57374.1 - 7.1e-05 22.8 1.7 0.034 14.0 0.1 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK57374.1 - 0.00077 19.1 4.1 0.0015 18.2 4.1 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK57375.1 - 3.8e-98 329.6 0.5 4.1e-64 217.3 0.0 3.0 1 1 2 3 3 3 3 Carboxylesterase family AChE_tetra PF08674.10 PIK57375.1 - 0.00075 19.1 3.2 0.0023 17.6 3.2 1.9 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.13 PIK57375.1 - 0.0011 18.8 2.3 0.02 14.7 0.1 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold TPR_1 PF00515.28 PIK57376.1 - 1.3e-13 50.1 0.2 6.8e-05 22.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK57376.1 - 4e-11 42.2 0.1 0.0096 16.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat CS PF04969.16 PIK57376.1 - 2.3e-08 35.0 0.1 6.1e-08 33.6 0.1 1.8 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.6 PIK57376.1 - 7.8e-07 28.7 0.1 0.008 15.8 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 PIK57376.1 - 1.3e-05 25.4 0.0 0.53 10.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57376.1 - 0.00041 20.3 2.7 1.3 9.5 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK57376.1 - 0.0008 20.0 0.0 0.073 13.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK57376.1 - 0.0048 17.0 0.1 4.3 7.6 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK57376.1 - 0.025 15.0 1.6 1.3 9.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CSG2 PF16965.5 PIK57376.1 - 0.69 8.8 4.7 19 4.1 0.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator DUF4407 PF14362.6 PIK57376.1 - 1.1 8.6 9.7 1.5 8.1 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 PIK57376.1 - 2 5.8 19.8 2.8 5.4 19.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Presenilin PF01080.17 PIK57376.1 - 2.9 6.6 11.1 3.5 6.3 11.1 1.1 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 PIK57376.1 - 3.8 6.3 3.9 5.8 5.7 3.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF334 PF03904.13 PIK57376.1 - 4.8 6.7 15.0 7.8 6.0 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) PA26 PF04636.13 PIK57376.1 - 5.4 5.8 9.4 7.7 5.3 9.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) cwf18 PF08315.12 PIK57377.1 - 1.8e-36 125.8 15.8 2.6e-36 125.3 15.8 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Arg_tRNA_synt_N PF03485.16 PIK57377.1 - 0.00048 20.7 0.8 0.00094 19.7 0.8 1.5 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Imm70 PF15601.6 PIK57377.1 - 0.05 13.2 0.1 0.067 12.7 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 70 Spore_III_AB PF09548.10 PIK57377.1 - 0.36 10.9 1.6 0.74 9.9 1.5 1.8 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) cNMP_binding PF00027.29 PIK57379.1 - 1.3e-15 57.2 0.1 1.5e-14 53.9 0.0 2.4 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain FAA_hydrolase PF01557.18 PIK57380.1 - 3.7e-59 200.0 0.0 4.2e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family OB_NTP_bind PF07717.16 PIK57381.1 - 9.8e-15 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 PIK57382.1 - 3.1e-16 59.6 1.4 8.8e-16 58.1 0.1 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 PIK57382.1 - 3.4e-13 49.7 0.1 8e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK57382.1 - 4.4e-13 49.5 0.2 3.1e-12 46.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 PIK57382.1 - 2.5e-07 31.0 0.2 8.2e-06 26.1 0.1 2.8 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 PIK57382.1 - 0.00011 21.4 0.0 0.0002 20.5 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 PIK57382.1 - 0.00033 21.0 0.0 0.001 19.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 PIK57382.1 - 0.0024 17.3 0.0 0.0057 16.0 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_29 PF13555.6 PIK57382.1 - 0.025 14.3 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 PIK57382.1 - 0.03 14.3 0.0 0.079 12.9 0.0 1.8 1 0 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.18 PIK57382.1 - 0.056 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 PIK57382.1 - 0.1 13.0 0.3 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 PIK57382.1 - 0.11 13.0 0.0 0.45 11.0 0.0 2.1 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 PIK57382.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain dsRBD2 PF17842.1 PIK57382.1 - 1.2 9.3 8.4 2.4 8.4 0.2 3.4 2 1 1 3 3 3 0 Double-stranded RNA binding domain 2 EPL1 PF10513.9 PIK57384.1 - 4.1e-14 53.3 0.9 4.1e-14 53.3 0.9 2.2 2 1 0 2 2 2 1 Enhancer of polycomb-like Eapp_C PF10238.9 PIK57384.1 - 7.8 6.6 7.8 1.2 9.3 0.2 2.9 3 0 0 3 3 3 0 E2F-associated phosphoprotein COesterase PF00135.28 PIK57385.1 - 1.3e-70 238.8 9.3 5.2e-46 157.6 1.4 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK57385.1 - 2.1e-10 40.8 0.2 4.4e-10 39.8 0.2 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 PIK57385.1 - 7.1e-07 28.8 1.3 7.1e-07 28.8 1.3 2.2 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Peptidase_S9 PF00326.21 PIK57385.1 - 0.002 17.7 0.1 0.0054 16.2 0.1 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 PIK57386.1 - 2.9e-30 105.6 0.1 3.3e-30 105.5 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family LRR19-TM PF15176.6 PIK57387.1 - 0.043 13.8 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Vpu PF00558.19 PIK57387.1 - 0.075 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Vpu protein SHMT PF00464.19 PIK57388.1 - 1.8e-161 537.2 0.0 1.3e-131 438.9 0.0 2.1 2 0 0 2 2 2 2 Serine hydroxymethyltransferase zf-MYND PF01753.18 PIK57390.1 - 2.1e-09 37.3 18.9 4.9e-09 36.1 18.9 1.7 1 0 0 1 1 1 1 MYND finger DUF1682 PF07946.14 PIK57390.1 - 0.0071 15.6 10.6 0.009 15.3 10.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) PPL5 PF18168.1 PIK57390.1 - 0.26 10.5 7.7 0.35 10.1 7.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 AAA_23 PF13476.6 PIK57390.1 - 0.38 11.2 10.3 0.46 11.0 10.3 1.1 1 0 0 1 1 1 0 AAA domain PolC_DP2 PF03833.13 PIK57390.1 - 0.48 8.2 14.1 0.55 8.0 14.1 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF913 PF06025.12 PIK57390.1 - 1.3 8.0 6.4 1.4 7.8 6.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MCM_bind PF09739.9 PIK57390.1 - 1.7 7.0 11.7 1.9 6.8 11.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor zf-C6H2 PF15801.5 PIK57390.1 - 2 8.8 16.1 4.5 7.7 16.1 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PTPRCAP PF15713.5 PIK57390.1 - 3.9 7.7 15.4 5.2 7.4 15.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TFB6 PF17110.5 PIK57390.1 - 10 5.9 8.3 13 5.5 8.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Ank_2 PF12796.7 PIK57391.1 - 1.5e-15 57.5 0.2 2.8e-08 34.2 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK57391.1 - 1.4e-11 44.7 0.0 1.4e-05 25.6 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK57391.1 - 1.6e-11 43.3 0.1 3.7e-05 23.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 PIK57391.1 - 8.6e-11 41.8 2.1 3e-05 24.3 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK57391.1 - 1.6e-10 41.0 0.3 8.5e-05 22.8 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) RNA_pol_Rpb1_4 PF05000.17 PIK57391.1 - 0.018 14.9 0.1 0.072 13.0 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 4 Pyr_redox_2 PF07992.14 PIK57392.1 - 1.7e-15 57.0 0.0 5.2e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK57392.1 - 0.0089 16.6 0.5 1.8 9.2 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK57392.1 - 0.068 12.4 0.0 12 5.0 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK57392.1 - 0.077 13.0 0.0 4.6 7.2 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding KH_1 PF00013.29 PIK57393.1 - 2.2e-18 65.8 0.4 2.8e-18 65.5 0.4 1.1 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 PIK57393.1 - 0.0039 17.0 0.6 0.0057 16.5 0.5 1.3 1 1 0 1 1 1 1 KH domain KH_4 PF13083.6 PIK57393.1 - 0.0077 16.1 0.6 0.012 15.4 0.5 1.5 1 1 0 1 1 1 1 KH domain FMN_dh PF01070.18 PIK57394.1 - 2.3e-54 184.8 0.0 2.7e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK57394.1 - 7.3e-09 35.1 2.0 1.7e-08 33.9 2.0 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK57394.1 - 9.7e-05 21.7 0.2 0.00019 20.7 0.2 1.6 1 1 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK57394.1 - 0.0014 18.1 1.1 0.0021 17.5 1.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK57394.1 - 0.021 14.3 0.3 0.14 11.6 0.3 2.1 1 1 0 1 1 1 0 Histidine biosynthesis protein G3P_antiterm PF04309.12 PIK57394.1 - 0.087 12.2 0.0 14 5.1 0.0 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator DUF2117 PF09890.9 PIK57394.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) AA_permease_2 PF13520.6 PIK57395.1 - 6.7e-43 147.1 36.3 8.3e-43 146.8 36.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK57395.1 - 2.6e-18 65.9 31.8 3.9e-18 65.3 31.8 1.1 1 0 0 1 1 1 1 Amino acid permease FMN_dh PF01070.18 PIK57396.1 - 9.2e-39 133.4 0.0 1.1e-38 133.2 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase fn1 PF00039.18 PIK57396.1 - 0.097 12.9 1.0 1.5 9.0 0.1 2.5 2 0 0 2 2 2 0 Fibronectin type I domain SRCR PF00530.18 PIK57397.1 - 6.4e-08 33.0 0.1 1e-07 32.3 0.1 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK57397.1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK57398.1 - 0.00031 21.2 0.0 0.00043 20.7 0.0 1.2 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK57399.1 - 2.1e-09 37.8 1.3 3.1e-07 30.8 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Shisa PF13908.6 PIK57399.1 - 0.0029 17.9 0.6 0.0029 17.9 0.6 2.9 1 1 1 3 3 3 1 Wnt and FGF inhibitory regulator SRCR PF00530.18 PIK57400.1 - 0.034 14.6 10.3 0.82 10.2 4.6 2.4 2 0 0 2 2 2 0 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK57403.1 - 2.5e-12 47.2 8.5 4e-08 33.7 0.1 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain RT_RNaseH_2 PF17919.1 PIK57404.1 - 2.9e-36 123.5 0.0 5.7e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57404.1 - 4.3e-35 120.2 0.0 8.6e-35 119.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK57404.1 - 2e-21 76.4 0.0 5.3e-21 75.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK57404.1 - 3e-21 76.0 0.1 8.5e-21 74.5 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK57404.1 - 1.8e-15 56.8 0.6 3.7e-15 55.8 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK57404.1 - 0.00024 20.8 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK57404.1 - 0.00095 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Alpha-amylase PF00128.24 PIK57405.1 - 4e-12 46.4 0.0 8.1e-12 45.3 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 PIK57405.1 - 2.8e-10 40.5 0.0 6.7e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Metallophos PF00149.28 PIK57406.1 - 1.9e-09 38.3 0.2 4.3e-09 37.2 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK57406.1 - 6e-05 23.3 0.1 0.0001 22.6 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RskA PF10099.9 PIK57406.1 - 0.0029 17.9 2.3 0.0045 17.3 2.3 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF508 PF04370.12 PIK57406.1 - 0.015 15.0 2.4 0.035 13.8 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF508) SR-25 PF10500.9 PIK57406.1 - 0.031 13.9 18.8 0.049 13.2 18.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 PIK57406.1 - 0.1 13.5 4.0 0.18 12.7 4.0 1.4 1 0 0 1 1 1 0 Chorion family 2 Pex14_N PF04695.13 PIK57406.1 - 0.13 12.9 4.9 0.21 12.3 4.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPX PF03105.19 PIK57406.1 - 0.26 11.2 3.9 0.35 10.7 3.9 1.1 1 0 0 1 1 1 0 SPX domain BUD22 PF09073.10 PIK57406.1 - 0.28 10.5 3.0 0.37 10.1 3.0 1.1 1 0 0 1 1 1 0 BUD22 AF-4 PF05110.13 PIK57406.1 - 0.9 7.5 20.0 1.1 7.2 20.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Mito_fiss_reg PF05308.11 PIK57406.1 - 1.1 9.3 8.8 1.9 8.5 8.8 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-C3HC4_2 PF13923.6 PIK57407.1 - 5.3e-10 39.0 10.7 5.3e-10 39.0 10.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK57407.1 - 9.4e-09 35.0 3.9 9.4e-09 35.0 3.9 2.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK57407.1 - 1.2e-08 34.9 6.3 1.2e-08 34.9 6.3 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK57407.1 - 1.3e-08 35.0 8.1 1.3e-08 35.0 8.1 3.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 PIK57407.1 - 2.6e-08 33.6 8.0 2.6e-08 33.6 8.0 2.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK57407.1 - 3.7e-08 33.4 9.8 3.7e-08 33.4 9.8 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK57407.1 - 7.9e-07 28.9 6.7 7.9e-07 28.9 6.7 3.0 3 2 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK57407.1 - 0.00029 20.6 11.2 0.00029 20.6 11.2 3.5 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 U-box PF04564.15 PIK57407.1 - 0.0045 17.1 0.2 0.014 15.5 0.1 1.8 2 0 0 2 2 2 1 U-box domain zf-Di19 PF05605.12 PIK57407.1 - 0.0056 17.0 14.4 0.023 15.0 0.2 3.3 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 PIK57407.1 - 0.022 14.6 0.7 0.13 12.2 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif UBZ_FAAP20 PF15750.5 PIK57407.1 - 0.25 11.3 0.2 0.25 11.3 0.2 3.1 2 1 1 3 3 3 0 Ubiquitin-binding zinc-finger zf_C2HC_14 PF18574.1 PIK57407.1 - 0.39 10.5 6.2 9.1 6.2 6.2 2.8 1 1 0 1 1 1 0 C2HC Zing finger domain zf-RING_11 PF17123.5 PIK57407.1 - 1 9.1 8.2 1.8 8.4 5.8 2.6 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 PIK57407.1 - 9.5 6.6 21.0 0.42 10.9 9.3 3.4 2 2 0 2 2 2 0 RING-H2 zinc finger domain NIT PF08376.10 PIK57409.1 - 2.1e-22 80.8 0.0 2.4e-22 80.5 0.0 1.0 1 0 0 1 1 1 1 Nitrate and nitrite sensing NIT PF08376.10 PIK57410.1 - 8.3e-08 33.0 0.0 1.2e-07 32.5 0.0 1.1 1 0 0 1 1 1 1 Nitrate and nitrite sensing ZYG-11_interact PF05884.12 PIK57410.1 - 0.031 13.7 0.3 0.043 13.2 0.3 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 Mannosyl_trans PF05007.13 PIK57411.1 - 2.8e-71 240.4 17.3 2.8e-71 240.4 17.3 1.9 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 PIK57411.1 - 2.6e-14 53.1 27.2 3.4e-14 52.7 27.2 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U PMP1_2 PF08114.11 PIK57411.1 - 0.056 13.2 0.0 0.19 11.5 0.0 1.9 1 0 0 1 1 1 0 ATPase proteolipid family PigN PF04987.14 PIK57412.1 - 1.3e-126 423.2 46.3 1.6e-126 422.8 46.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 PIK57412.1 - 1.9e-10 40.9 2.6 4.1e-10 39.8 2.6 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase TetR_C_28 PF17937.1 PIK57412.1 - 0.021 15.3 0.0 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 PIK57413.1 - 5.1e-10 39.8 13.0 0.00026 21.7 0.1 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57413.1 - 6.2e-06 26.4 0.7 0.046 14.0 0.1 3.0 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Zn_ribbon_17 PF17120.5 PIK57414.1 - 3.5e-10 39.4 14.5 3.5e-10 39.4 14.5 2.3 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 PIK57414.1 - 2.5e-07 31.0 6.7 2.5e-07 31.0 6.7 2.9 2 1 1 3 3 3 1 Zinc-ribbon like family V-set PF07686.17 PIK57415.1 - 0.0039 17.3 1.7 0.014 15.6 0.2 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain CDC37_C PF08564.10 PIK57416.1 - 0.0084 16.2 0.1 0.023 14.8 0.0 1.7 2 0 0 2 2 2 1 Cdc37 C terminal domain PUFD PF16553.5 PIK57416.1 - 0.1 12.7 0.1 0.31 11.2 0.0 1.8 2 0 0 2 2 2 0 BCORL-PCGF1-binding domain MICSWaP PF17018.5 PIK57416.1 - 0.11 12.0 0.3 0.16 11.5 0.3 1.2 1 0 0 1 1 1 0 Spore wall protein Ras PF00071.22 PIK57417.1 - 5.2e-35 120.4 0.0 7.3e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57417.1 - 1.5e-11 44.6 0.0 3.5e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK57417.1 - 6.2e-07 29.5 0.0 0.0028 17.6 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 PIK57417.1 - 1.8e-05 24.8 0.0 3.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 PIK57417.1 - 0.0002 20.8 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 PIK57417.1 - 0.00045 20.6 0.0 0.00079 19.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 PIK57417.1 - 0.00083 18.9 0.0 0.0036 16.8 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 PIK57417.1 - 0.01 15.4 0.0 0.026 14.0 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B RNA_helicase PF00910.22 PIK57417.1 - 0.022 15.1 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 PIK57417.1 - 0.035 14.4 0.0 0.28 11.4 0.0 2.4 2 1 1 3 3 3 0 AAA domain AIG1 PF04548.16 PIK57417.1 - 0.037 13.3 0.0 0.067 12.5 0.0 1.5 1 0 0 1 1 1 0 AIG1 family AAA_5 PF07728.14 PIK57417.1 - 0.06 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RAG2 PF03089.14 PIK57417.1 - 0.073 12.0 0.2 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Recombination activating protein 2 ABC_tran PF00005.27 PIK57417.1 - 0.073 13.6 0.1 0.3 11.6 0.1 2.1 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 PIK57417.1 - 0.096 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 PIK57417.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK57417.1 - 0.17 11.7 0.3 2.4 8.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 PIK57417.1 - 0.21 11.7 2.1 12 6.0 0.0 2.9 3 0 0 3 3 3 0 Dynamin family Somatomedin_B PF01033.17 PIK57418.1 - 0.0019 18.5 8.5 0.012 16.0 8.5 2.5 1 0 0 1 1 1 1 Somatomedin B domain MMS1_N PF10433.9 PIK57420.1 - 1.8e-123 412.8 0.0 4.8e-118 394.9 0.0 2.6 2 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 PIK57420.1 - 2.6e-100 335.9 0.1 2e-99 332.9 0.0 2.4 3 0 0 3 3 3 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 PIK57420.1 - 0.13 12.6 0.0 0.92 9.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 PF13923.6 PIK57421.1 - 4.6e-13 48.8 6.9 9.3e-13 47.8 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK57421.1 - 2.8e-11 43.1 5.9 2.8e-11 43.1 5.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK57421.1 - 2.1e-10 40.4 7.4 4.6e-10 39.3 7.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK57421.1 - 9.6e-10 38.6 6.3 2.2e-09 37.5 6.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK57421.1 - 1.5e-07 31.4 5.5 3.7e-07 30.2 5.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK57421.1 - 1.8e-07 30.9 5.3 4e-07 29.8 5.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK57421.1 - 3.6e-06 27.2 7.2 5.7e-06 26.5 5.6 2.2 2 1 0 2 2 1 1 RING-H2 zinc finger domain U-box PF04564.15 PIK57421.1 - 2.8e-05 24.2 0.1 7.5e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 U-box domain Prok-RING_4 PF14447.6 PIK57421.1 - 3e-05 23.8 4.5 6.9e-05 22.6 4.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK57421.1 - 5.5e-05 23.0 5.2 0.00013 21.8 5.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 PIK57421.1 - 0.0075 16.4 4.1 0.0075 16.4 4.1 1.7 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 PIK57421.1 - 0.017 15.0 1.8 0.038 13.9 1.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 PIK57421.1 - 0.018 14.9 2.4 0.04 13.7 2.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 PIK57421.1 - 0.038 14.0 1.7 0.038 14.0 1.7 1.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 PIK57421.1 - 0.092 12.5 4.9 0.39 10.5 5.0 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 PIK57421.1 - 0.22 11.3 5.1 0.58 9.9 5.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger GTP_EFTU_D3 PF03143.17 PIK57422.1 - 3.1e-30 104.8 0.2 1.2e-29 102.9 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 PIK57422.1 - 8.7e-23 80.9 0.0 2.2e-11 43.7 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain PAM2 PF07145.15 PIK57422.1 - 1.1e-06 27.9 7.5 0.00048 19.6 1.0 2.6 1 1 1 2 2 2 2 Ataxin-2 C-terminal region GTP_EFTU_D2 PF03144.25 PIK57422.1 - 0.0006 20.2 0.1 0.0054 17.1 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu domain 2 LPD34 PF18852.1 PIK57422.1 - 0.032 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 CDC27 PF09507.10 PIK57422.1 - 0.38 10.1 15.2 0.64 9.3 15.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RNase_H2_suC PF08615.11 PIK57422.1 - 2 8.6 4.7 4.4 7.5 4.7 1.7 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Telomere_reg-2 PF10193.9 PIK57423.1 - 1.6e-36 125.1 0.1 8.2e-36 122.8 0.1 2.4 1 0 0 1 1 1 1 Telomere length regulation protein RIX1 PF08167.12 PIK57423.1 - 5.6 6.7 8.7 23 4.7 0.0 3.9 5 0 0 5 5 5 0 rRNA processing/ribosome biogenesis GTP_EFTU PF00009.27 PIK57424.1 - 1.9e-21 76.5 0.0 3.5e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK57424.1 - 0.0032 17.5 0.1 0.0074 16.4 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 PIK57424.1 - 0.005 17.2 2.3 0.0079 16.6 1.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 PIK57424.1 - 0.0053 17.0 0.5 0.036 14.4 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain PduV-EutP PF10662.9 PIK57424.1 - 0.0072 16.1 0.0 5.7 6.7 0.0 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 PIK57424.1 - 0.081 12.8 0.1 12 5.8 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase Arf PF00025.21 PIK57424.1 - 0.098 12.1 0.1 3.8 6.9 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family LRAT PF04970.13 PIK57425.1 - 6.5e-18 65.2 0.6 2.2e-09 37.7 0.1 2.1 1 1 1 2 2 2 2 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 PIK57425.1 - 0.0067 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 NlpC/P60 family ORC_WH_C PF18137.1 PIK57425.1 - 0.13 12.3 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Solute_trans_a PF03619.16 PIK57427.1 - 1.9e-66 224.3 20.0 3.9e-37 128.2 2.5 2.9 3 0 0 3 3 3 2 Organic solute transporter Ostalpha SNF PF00209.18 PIK57428.1 - 1.8e-38 132.6 17.4 1.4e-28 99.9 9.6 2.1 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family SNF PF00209.18 PIK57429.1 - 0.0032 16.2 0.4 0.0042 15.8 0.4 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Y_phosphatase PF00102.27 PIK57430.1 - 9.8e-57 192.2 0.2 1.7e-56 191.4 0.2 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK57430.1 - 2.5e-17 63.0 10.2 5.1e-09 36.4 0.7 2.9 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57430.1 - 0.0001 22.8 8.1 0.028 15.0 0.6 3.0 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK57430.1 - 0.002 18.4 4.4 0.12 12.7 0.2 3.1 2 1 1 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III DUF2207 PF09972.9 PIK57430.1 - 0.01 14.6 0.0 0.02 13.7 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PTPlike_phytase PF14566.6 PIK57430.1 - 0.063 13.4 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate TRAP_beta PF05753.14 PIK57430.1 - 0.14 11.6 0.2 0.43 10.0 0.0 1.8 1 1 0 2 2 2 0 Translocon-associated protein beta (TRAPB) EGF_2 PF07974.13 PIK57431.1 - 0.0078 16.6 16.7 0.0078 16.6 16.7 3.7 3 1 0 3 3 3 1 EGF-like domain hEGF PF12661.7 PIK57431.1 - 0.0084 16.7 8.2 0.0084 16.7 8.2 4.9 6 0 0 6 6 6 1 Human growth factor-like EGF Ig_3 PF13927.6 PIK57432.1 - 0.0018 18.8 0.6 0.053 14.1 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK57432.1 - 0.0042 17.4 0.4 0.02 15.3 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK57432.1 - 0.0059 17.0 0.3 0.04 14.3 0.0 2.3 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK57432.1 - 0.014 15.6 0.1 0.14 12.5 0.0 2.4 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK57432.1 - 0.022 15.0 0.1 0.072 13.3 0.0 1.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain Izumo-Ig PF16706.5 PIK57432.1 - 0.094 12.8 0.1 0.37 10.9 0.0 2.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Y_phosphatase PF00102.27 PIK57433.1 - 6.5e-17 61.9 0.0 7e-17 61.8 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK57433.1 - 0.0058 16.6 0.0 0.0063 16.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family INT_SG_DDX_CT_C PF15300.6 PIK57433.1 - 0.025 14.4 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 INTS6/SAGE1/DDX26B/CT45 C-terminus fn3 PF00041.21 PIK57434.1 - 1.8e-11 44.2 1.0 3.6e-05 24.0 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain fn3_2 PF16893.5 PIK57434.1 - 0.16 12.2 0.2 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 Fibronectin type III domain Peptidase_A17 PF05380.13 PIK57435.1 - 2.4e-12 47.1 0.1 3.9e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1758 PF05585.12 PIK57436.1 - 0.00061 19.6 0.2 0.00089 19.1 0.2 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) RVP_2 PF08284.11 PIK57436.1 - 0.0084 15.9 0.2 0.013 15.3 0.2 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK57436.1 - 0.032 14.9 0.0 0.055 14.1 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 PIK57436.1 - 0.095 13.3 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Ig_3 PF13927.6 PIK57437.1 - 0.00049 20.6 0.5 0.041 14.5 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK57437.1 - 0.0069 16.4 0.0 0.12 12.4 0.0 2.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK57437.1 - 0.0074 16.5 0.0 0.2 11.9 0.0 2.7 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.6 PIK57437.1 - 0.0093 16.3 1.0 0.074 13.4 0.0 2.5 2 1 1 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.5 PIK57437.1 - 0.047 14.1 0.2 0.82 10.1 0.0 2.6 2 1 1 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK57437.1 - 0.11 12.0 0.0 0.76 9.4 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK57437.1 - 0.15 12.3 0.8 0.77 10.0 0.0 2.5 2 2 1 3 3 3 0 Immunoglobulin V-set domain Y_phosphatase PF00102.27 PIK57438.1 - 5.3e-48 163.6 0.5 8.2e-48 163.0 0.5 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK57438.1 - 1.9e-07 31.4 0.4 5.6e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57438.1 - 0.044 14.3 0.2 0.2 12.3 0.0 2.2 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain DSPc PF00782.20 PIK57438.1 - 0.071 12.9 1.4 0.17 11.7 0.1 2.1 2 1 1 3 3 3 0 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK57439.1 - 3.7e-10 40.0 1.4 6e-06 26.5 0.4 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57439.1 - 0.0004 20.9 4.5 0.027 15.0 0.9 2.1 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain DUF568 PF04526.13 PIK57439.1 - 0.16 12.7 0.2 0.22 12.3 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF568) Y_phosphatase PF00102.27 PIK57440.1 - 4.2e-97 324.3 2.2 1.3e-74 250.7 0.6 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK57440.1 - 0.00018 21.3 0.5 0.0017 18.1 0.1 2.4 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK57440.1 - 0.00062 19.8 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK57440.1 - 0.00089 19.4 0.3 0.0035 17.5 0.0 2.1 2 0 0 2 2 2 1 Inositol hexakisphosphate hEGF PF12661.7 PIK57441.1 - 7.7e-05 23.2 7.2 7.7e-05 23.2 7.2 2.8 4 0 0 4 4 4 1 Human growth factor-like EGF Ig_3 PF13927.6 PIK57441.1 - 0.00019 22.0 1.2 0.028 15.0 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK57441.1 - 0.0015 18.8 1.4 0.014 15.7 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK57441.1 - 0.0046 17.0 0.1 0.033 14.2 0.0 2.3 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 PIK57441.1 - 0.0051 17.2 0.0 0.0051 17.2 0.0 3.1 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain EGF_2 PF07974.13 PIK57441.1 - 0.015 15.7 16.9 0.036 14.4 16.9 1.7 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 PIK57441.1 - 0.033 14.5 12.3 0.033 14.5 12.3 2.2 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 PIK57441.1 - 0.042 14.0 9.1 0.14 12.3 9.1 1.9 1 1 0 1 1 1 0 Laminin EGF domain I-set PF07679.16 PIK57441.1 - 0.043 13.9 1.3 0.11 12.5 0.2 2.3 2 1 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.17 PIK57441.1 - 0.053 13.7 1.7 0.17 12.1 0.1 2.3 2 2 0 2 2 2 0 Immunoglobulin V-set domain fn3 PF00041.21 PIK57442.1 - 4.8e-15 55.7 0.8 3e-09 37.1 0.2 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57442.1 - 3.9e-06 27.4 0.9 0.00034 21.1 0.2 2.3 1 1 1 2 2 2 2 Purple acid Phosphatase, N-terminal domain FliW PF02623.15 PIK57442.1 - 0.0086 16.0 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 FliW protein hEGF PF12661.7 PIK57443.1 - 7.1e-05 23.3 7.2 7.1e-05 23.3 7.2 3.3 5 0 0 5 5 5 1 Human growth factor-like EGF Izumo-Ig PF16706.5 PIK57443.1 - 0.0087 16.1 0.0 0.078 13.0 0.0 2.2 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain EGF_2 PF07974.13 PIK57443.1 - 0.0095 16.3 16.7 0.026 14.9 16.7 1.8 1 0 0 1 1 1 1 EGF-like domain Ig_2 PF13895.6 PIK57443.1 - 0.015 15.6 0.1 0.14 12.5 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Ig_5 PF16681.5 PIK57443.1 - 0.027 14.9 1.6 0.2 12.1 0.0 2.8 4 0 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 PIK57443.1 - 0.045 13.9 0.1 0.16 12.1 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK57443.1 - 0.093 13.3 0.5 0.4 11.3 0.0 2.3 2 2 0 2 2 2 0 Immunoglobulin domain Laminin_EGF PF00053.24 PIK57443.1 - 0.14 12.3 9.0 0.47 10.6 9.0 1.9 1 1 0 1 1 1 0 Laminin EGF domain EGF PF00008.27 PIK57443.1 - 0.22 11.9 16.8 0.083 13.2 12.8 2.4 2 0 0 2 2 2 0 EGF-like domain Syndecan PF01034.20 PIK57444.1 - 0.12 12.3 1.7 0.19 11.7 1.7 1.3 1 0 0 1 1 1 0 Syndecan domain Y_phosphatase PF00102.27 PIK57445.1 - 1.2e-23 83.9 0.9 1.9e-12 47.3 0.1 2.0 1 1 1 2 2 2 2 Protein-tyrosine phosphatase COesterase PF00135.28 PIK57446.1 - 3.4e-31 108.7 0.0 4.1e-31 108.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK57447.1 - 1.3e-28 100.2 0.0 1.5e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 PIK57448.1 - 7.4e-95 318.7 0.0 8.3e-95 318.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK57448.1 - 3.1e-06 27.2 0.1 1.4e-05 25.1 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 PIK57448.1 - 0.18 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase COesterase PF00135.28 PIK57449.1 - 6.4e-114 381.6 0.0 7.6e-114 381.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK57449.1 - 0.00081 19.3 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ion_trans PF00520.31 PIK57450.1 - 6e-15 55.1 2.7 8.2e-15 54.7 2.7 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 PIK57450.1 - 1.1e-11 44.5 8.4 3.3e-11 43.0 8.3 1.8 1 1 1 2 2 2 1 Ion channel CD225 PF04505.12 PIK57450.1 - 0.071 13.3 0.1 0.22 11.7 0.1 1.8 1 0 0 1 1 1 0 Interferon-induced transmembrane protein TFIID_20kDa PF03847.13 PIK57450.1 - 0.2 12.2 0.0 0.41 11.2 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Lig_chan PF00060.26 PIK57450.1 - 0.62 9.9 3.0 1.6 8.5 3.0 1.6 1 1 0 1 1 1 0 Ligand-gated ion channel HA70_C PF17993.1 PIK57451.1 - 0.08 13.0 0.1 46 4.1 0.0 3.5 2 1 3 5 5 5 0 Haemagglutinin 70 C-terminal domain M-factor PF03855.13 PIK57451.1 - 2 8.6 16.8 33 4.7 0.1 5.7 3 1 3 6 6 6 0 M-factor Ion_trans PF00520.31 PIK57452.1 - 8.8e-06 25.1 1.3 8.9e-06 25.1 1.3 1.1 1 0 0 1 1 1 1 Ion transport protein YfhO PF09586.10 PIK57452.1 - 0.0088 14.3 2.4 0.0091 14.3 2.4 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO PTE PF02126.18 PIK57452.1 - 0.11 12.0 0.1 0.15 11.5 0.1 1.3 1 1 0 1 1 1 0 Phosphotriesterase family GPR_Gpa2_C PF11970.8 PIK57453.1 - 9e-07 28.9 1.2 9e-07 28.9 1.2 1.9 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF3671 PF12420.8 PIK57453.1 - 0.074 13.1 0.2 0.074 13.1 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function GTA_holin_3TM PF11351.8 PIK57453.1 - 0.29 11.7 5.7 0.35 11.4 4.8 1.6 1 1 0 1 1 1 0 Holin of 3TMs, for gene-transfer release RhoGAP PF00620.27 PIK57454.1 - 3e-24 85.6 0.7 5.1e-24 84.8 0.3 1.5 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 PIK57454.1 - 2.5e-14 53.6 3.3 2.9e-13 50.2 0.8 2.7 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 PIK57454.1 - 0.00017 21.3 0.5 0.00051 19.8 0.2 1.9 2 0 0 2 2 2 1 CRAL/TRIO domain Rapsyn_N PF10579.9 PIK57455.1 - 7.2e-18 64.5 0.7 1.9e-14 53.5 0.2 2.1 2 0 0 2 2 2 2 Rapsyn N-terminal myristoylation and linker region TPR_12 PF13424.6 PIK57455.1 - 3.9e-11 43.1 4.3 1.1e-05 25.6 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK57455.1 - 2e-07 31.5 1.9 0.052 14.2 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK57455.1 - 4.4e-07 29.5 5.8 0.012 15.7 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57455.1 - 0.00027 20.9 1.6 4.8 7.6 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK57455.1 - 0.0011 19.6 2.5 0.25 12.3 0.1 3.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK57455.1 - 0.0074 16.2 0.6 3.5 7.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 PIK57455.1 - 0.029 14.4 1.0 1 9.4 0.4 2.6 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) CBFD_NFYB_HMF PF00808.23 PIK57455.1 - 0.12 12.7 0.1 0.3 11.4 0.0 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF4398 PF14346.6 PIK57455.1 - 0.29 11.8 2.7 17 6.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) TPR_6 PF13174.6 PIK57455.1 - 0.84 10.4 3.3 15 6.5 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK57455.1 - 3 8.7 10.4 22 6.0 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 PIK57456.1 - 1.4e-06 28.5 8.0 1.4e-06 28.5 8.0 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 PIK57456.1 - 1.2e-05 25.0 7.1 1.2e-05 25.0 7.1 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 PIK57456.1 - 2e-05 24.5 9.9 4e-05 23.5 9.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK57456.1 - 7.5e-05 22.5 7.9 0.00016 21.4 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_MalT PF17874.1 PIK57456.1 - 0.00049 19.6 0.2 0.025 14.0 0.2 1.8 1 1 1 2 2 2 2 MalT-like TPR region zf-C3HC4_3 PF13920.6 PIK57456.1 - 0.0023 17.8 8.2 0.0048 16.7 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK57456.1 - 0.0077 16.1 9.3 0.014 15.2 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 PIK57456.1 - 0.0083 16.4 1.4 0.25 11.7 0.1 1.6 1 1 1 2 2 2 2 Tetratricopeptide repeat zf-rbx1 PF12678.7 PIK57456.1 - 0.0096 16.2 6.0 0.021 15.1 6.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 PIK57456.1 - 0.02 14.7 3.9 0.042 13.7 3.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 PIK57456.1 - 0.027 14.5 2.3 0.12 12.4 2.5 2.0 1 1 1 2 2 2 0 RING-type zinc-finger TPR_2 PF07719.17 PIK57456.1 - 0.078 13.1 0.4 0.95 9.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1272 PF06906.11 PIK57456.1 - 0.18 11.9 3.1 0.34 11.0 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Zn_ribbon_17 PF17120.5 PIK57456.1 - 0.39 10.4 9.1 1.1 9.0 9.1 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Spt4 PF06093.13 PIK57456.1 - 1 9.5 6.9 10 6.3 2.9 3.1 1 1 2 3 3 3 0 Spt4/RpoE2 zinc finger zf-C3H2C3 PF17122.5 PIK57456.1 - 1.1 9.4 9.7 2.3 8.3 9.7 1.7 1 1 0 1 1 1 0 Zinc-finger PHD PF00628.29 PIK57456.1 - 2 8.4 9.8 4.1 7.4 9.8 1.6 1 0 0 1 1 1 0 PHD-finger 7tm_1 PF00001.21 PIK57457.1 - 2.7e-37 128.5 11.5 2.7e-37 128.5 11.5 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK57457.1 - 0.0015 18.2 14.6 0.0021 17.7 14.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_L4 PF00573.22 PIK57458.1 - 6.1 6.5 7.2 0.25 11.0 1.4 1.5 2 0 0 2 2 2 0 Ribosomal protein L4/L1 family CN_hydrolase PF00795.22 PIK57459.1 - 5e-37 127.6 0.1 1.3e-36 126.2 0.0 1.7 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 PIK57459.1 - 5.6e-11 42.0 0.0 1.9e-10 40.3 0.0 1.7 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 PIK57459.1 - 0.028 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase Abhydro_lipase PF04083.16 PIK57460.1 - 8.3e-23 79.7 0.0 8.1e-22 76.6 0.0 2.2 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 PIK57460.1 - 2.2e-22 80.0 0.2 8.1e-22 78.1 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 PIK57460.1 - 7.4e-08 31.9 0.0 6.6e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 PIK57460.1 - 0.0036 17.9 0.0 0.0042 17.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family SET PF00856.28 PIK57461.1 - 6e-05 23.5 1.7 0.00048 20.6 0.1 3.2 3 1 0 3 3 3 1 SET domain zf-Di19 PF05605.12 PIK57461.1 - 0.0098 16.2 0.5 0.1 12.9 0.3 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK57461.1 - 1 10.4 6.2 0.92 10.5 1.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 PIK57461.1 - 5.6 7.5 9.2 0.34 11.4 0.2 3.3 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain Linker_histone PF00538.19 PIK57463.1 - 2.5e-21 75.8 0.6 2.5e-21 75.8 0.6 2.6 2 1 1 3 3 3 1 linker histone H1 and H5 family SLC12 PF03522.15 PIK57463.1 - 0.44 9.5 10.5 0.55 9.2 10.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2486 PF10667.9 PIK57463.1 - 0.77 9.9 8.7 1.2 9.3 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) DUF3729 PF12526.8 PIK57463.1 - 1.1 10.8 4.0 2.6 9.7 4.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3729) RR_TM4-6 PF06459.12 PIK57463.1 - 2.8 7.7 15.7 3.2 7.5 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 PIK57463.1 - 2.9 7.9 8.4 2.9 7.9 8.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.32 PIK57464.1 - 1.2e-05 25.9 4.3 0.0012 19.6 0.4 3.9 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57464.1 - 0.021 15.1 0.0 1.5 9.2 0.0 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L23 PF00276.20 PIK57465.1 - 1e-13 51.5 0.0 1.6e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 Linker_histone PF00538.19 PIK57466.1 - 7.3e-21 74.3 0.6 7.3e-21 74.3 0.6 2.7 2 1 1 3 3 3 1 linker histone H1 and H5 family SLC12 PF03522.15 PIK57466.1 - 1.4 7.9 14.4 1.5 7.7 14.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2486 PF10667.9 PIK57466.1 - 2.1 8.5 17.3 2.9 8.0 17.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) SAPS PF04499.15 PIK57466.1 - 2.2 7.0 8.0 2.5 6.8 8.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Atg14 PF10186.9 PIK57466.1 - 7 5.6 15.4 7.5 5.5 15.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C2H2 PF00096.26 PIK57467.1 - 2.5e-44 147.3 129.9 3.3e-05 24.1 1.7 15.3 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK57467.1 - 3.2e-41 137.9 106.8 1.7e-07 31.3 0.3 15.5 15 1 0 15 15 15 12 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK57467.1 - 1.8e-30 103.0 122.0 0.00037 21.1 0.9 15.4 15 0 0 15 15 15 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK57467.1 - 9.9e-16 57.6 108.7 0.00014 22.1 1.6 14.5 15 0 0 15 15 15 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK57467.1 - 9.2e-14 51.3 100.7 0.001 19.4 0.2 14.9 15 0 0 15 15 15 7 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK57467.1 - 3e-09 36.6 106.7 0.00034 20.5 0.3 14.7 14 1 0 14 14 14 8 C2H2-type zinc finger zf-MYST PF17772.1 PIK57467.1 - 0.088 12.4 0.1 0.088 12.4 0.1 11.2 10 3 4 14 14 14 0 MYST family zinc finger domain Zn-C2H2_12 PF18112.1 PIK57467.1 - 0.66 10.5 0.1 0.66 10.5 0.1 8.2 8 0 0 8 8 8 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_8 PF15909.5 PIK57467.1 - 6 7.2 62.3 0.12 12.7 2.0 7.4 1 1 7 8 8 8 0 C2H2-type zinc ribbon BID PF06393.11 PIK57468.1 - 0.035 13.6 0.0 0.073 12.6 0.0 1.5 1 0 0 1 1 1 0 BH3 interacting domain (BID) Bcl-2 PF00452.19 PIK57468.1 - 0.082 13.6 0.3 0.32 11.7 0.1 2.0 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family LRR_8 PF13855.6 PIK57469.1 - 3e-34 116.6 25.4 8.3e-11 41.5 1.9 5.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 PIK57469.1 - 5.5e-17 61.9 5.0 3.1e-09 36.9 0.3 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK57469.1 - 1.6e-13 50.6 18.5 0.00031 21.1 2.4 6.1 4 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK57469.1 - 1.1e-10 41.3 5.5 0.00075 19.0 0.6 3.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 PIK57469.1 - 3.9e-06 26.7 14.2 3.2 8.7 0.1 8.1 9 0 0 9 9 9 1 Leucine Rich Repeat DUF2985 PF11204.8 PIK57469.1 - 0.17 12.1 0.1 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) fn3 PF00041.21 PIK57472.1 - 1.8e-21 76.3 6.7 9.7e-07 29.1 0.7 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57472.1 - 0.00034 21.1 1.5 0.97 10.1 0.0 3.5 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK57472.1 - 0.21 12.0 0.7 0.87 10.0 0.2 2.2 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) Y_phosphatase PF00102.27 PIK57473.1 - 3.8e-82 275.4 0.4 5.2e-82 274.9 0.4 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK57473.1 - 7.8e-06 25.7 0.0 2.1e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK57473.1 - 0.0003 20.9 0.0 0.00064 19.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK57473.1 - 0.00041 20.5 0.0 0.00087 19.4 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate PTP_tm PF18861.1 PIK57473.1 - 0.01 15.8 0.3 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J SOBP PF15279.6 PIK57474.1 - 0.16 12.6 15.5 0.21 12.2 15.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4537 PF15057.6 PIK57475.1 - 4.5e-25 88.0 0.0 8.2e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Dicty_CAR PF05462.11 PIK57476.1 - 1.8e-11 43.7 12.4 1.8e-11 43.7 12.4 1.6 1 1 0 2 2 2 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 PIK57476.1 - 0.00012 21.2 5.1 0.00012 21.2 5.1 1.7 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Transmemb_17 PF09799.9 PIK57476.1 - 0.077 13.6 0.3 0.077 13.6 0.3 2.8 3 1 0 3 3 3 0 Predicted membrane protein Rhabdo_M1 PF03342.13 PIK57476.1 - 0.19 11.1 0.2 0.26 10.6 0.2 1.1 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) 7TM_GPCR_Srx PF10328.9 PIK57476.1 - 0.27 10.8 11.1 14 5.2 11.1 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SEN1_N PF12726.7 PIK57478.1 - 1.3e-05 23.7 4.1 4.2e-05 22.0 4.1 1.7 1 1 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 PIK57479.1 - 7e-09 35.8 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK57479.1 - 0.0051 17.2 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 PIK57480.1 - 1.3e-23 83.6 0.1 2.3e-23 82.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK57480.1 - 3.3e-08 33.7 7.4 1.7e-07 31.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain ABC_tran_CTD PF16326.5 PIK57480.1 - 0.14 12.4 2.1 0.34 11.2 2.1 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain TMF_DNA_bd PF12329.8 PIK57480.1 - 2.5 8.2 7.8 1.2 9.2 0.3 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding zf-H2C2_2 PF13465.6 PIK57481.1 - 8.1e-90 291.6 159.7 4.7e-08 33.1 0.6 21.0 21 0 0 21 21 21 18 Zinc-finger double domain zf-C2H2 PF00096.26 PIK57481.1 - 1.7e-58 191.9 190.0 3.3e-05 24.1 1.6 22.2 23 0 0 23 23 22 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK57481.1 - 1.7e-53 174.6 176.0 0.00048 20.7 2.5 22.4 23 0 0 23 23 22 18 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK57481.1 - 3.3e-18 65.5 107.4 0.028 14.7 0.8 20.0 20 0 0 20 20 20 11 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK57481.1 - 1e-10 41.3 148.4 0.00037 20.4 1.5 21.3 21 2 0 21 21 21 9 C2H2-type zinc finger zf-met PF12874.7 PIK57481.1 - 2.2e-10 40.5 112.2 0.0042 17.4 0.2 19.9 20 0 0 20 20 20 9 Zinc-finger of C2H2 type BolA PF01722.18 PIK57481.1 - 4.1e-07 30.2 28.1 0.27 11.5 0.1 9.0 5 4 4 10 10 10 3 BolA-like protein BHD_1 PF10403.9 PIK57481.1 - 0.0022 17.8 8.6 0.73 9.7 0.0 5.4 6 1 0 6 6 6 1 Rad4 beta-hairpin domain 1 zf-H2C2_5 PF13909.6 PIK57481.1 - 0.033 14.0 0.1 0.033 14.0 0.1 16.7 17 2 0 17 17 17 0 C2H2-type zinc-finger domain zf_UBZ PF18439.1 PIK57481.1 - 0.11 12.1 98.1 2.2 7.9 0.1 19.3 21 0 0 21 21 21 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 PIK57481.1 - 0.63 10.8 94.8 0.35 11.6 1.1 11.4 5 5 6 12 12 12 0 zinc-ribbon family 2OG-FeII_Oxy PF03171.20 PIK57482.1 - 1.9e-18 66.8 0.0 3.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 PIK57482.1 - 9.2e-08 32.9 0.0 1.7e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 7tm_2 PF00002.24 PIK57483.1 - 6.7e-16 58.3 22.0 9e-16 57.9 22.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) CUB PF00431.20 PIK57484.1 - 1e-34 119.2 3.7 4.1e-27 94.7 0.2 2.9 3 0 0 3 3 3 2 CUB domain Gal-3-0_sulfotr PF06990.11 PIK57485.1 - 2.1e-49 168.5 0.4 2.7e-49 168.1 0.4 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 PIK57485.1 - 0.0062 16.0 0.1 0.015 14.8 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Ceramidase PF05875.12 PIK57486.1 - 1.1e-17 64.3 0.4 1.4e-17 64.0 0.4 1.0 1 0 0 1 1 1 1 Ceramidase HlyIII PF03006.20 PIK57486.1 - 0.15 11.7 3.0 0.22 11.2 3.0 1.4 1 1 0 1 1 1 0 Haemolysin-III related zf-C2H2 PF00096.26 PIK57488.1 - 8.3e-22 76.4 40.8 1.1e-05 25.6 1.2 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK57488.1 - 1.7e-19 68.8 38.8 0.00073 20.2 0.8 6.8 7 0 0 7 7 6 6 C2H2-type zinc finger zf-met PF12874.7 PIK57488.1 - 1.7e-10 40.9 15.8 0.017 15.5 0.2 6.5 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK57488.1 - 5.4e-09 35.8 34.0 0.011 15.7 0.5 6.7 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK57488.1 - 5.4e-08 32.9 24.8 0.15 12.4 0.8 7.2 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 PIK57488.1 - 6.3e-05 22.9 16.3 1.2 9.2 0.2 5.3 4 1 1 5 5 5 3 BED zinc finger zf-H2C2_2 PF13465.6 PIK57488.1 - 0.00021 21.5 0.8 0.00021 21.5 0.8 7.3 7 1 0 7 7 7 3 Zinc-finger double domain zinc_ribbon_15 PF17032.5 PIK57488.1 - 0.00072 20.3 14.6 0.045 14.5 1.7 3.6 2 1 1 3 3 3 2 zinc-ribbon family zf_UBZ PF18439.1 PIK57488.1 - 0.014 15.0 16.6 0.25 10.9 0.8 5.3 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Evr1_Alr PF04777.13 PIK57488.1 - 0.016 15.7 14.9 1.5 9.3 0.1 4.6 2 1 2 4 4 4 0 Erv1 / Alr family DUF1638 PF07796.11 PIK57488.1 - 0.035 14.2 0.0 0.061 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) CpXC PF14353.6 PIK57488.1 - 0.091 12.8 4.1 0.83 9.7 0.0 3.3 2 1 0 2 2 2 0 CpXC protein zf-C2H2_11 PF16622.5 PIK57488.1 - 0.11 12.2 0.2 0.11 12.2 0.2 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type FAM101 PF15068.6 PIK57488.1 - 0.13 12.2 0.7 1.2 9.1 0.2 2.5 2 1 0 2 2 2 0 FAM101 family zf-AN1 PF01428.16 PIK57488.1 - 0.74 10.0 25.0 4.8 7.4 1.9 6.2 6 0 0 6 6 6 0 AN1-like Zinc finger Yippee-Mis18 PF03226.14 PIK57488.1 - 2.4 8.4 12.4 2.8 8.2 0.0 4.2 3 2 2 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-CHCC PF10276.9 PIK57488.1 - 3.7 7.7 11.4 11 6.2 0.3 4.1 4 0 0 4 4 3 0 Zinc-finger domain HNH_5 PF14279.6 PIK57488.1 - 5.8 6.8 12.9 1.4 8.9 0.5 3.9 4 0 0 4 4 4 0 HNH endonuclease FKBP_C PF00254.28 PIK57489.1 - 4.4e-30 103.9 0.0 5.7e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Nucleoporin_C PF03177.14 PIK57490.1 - 5.2e-31 108.1 8.4 7e-26 91.1 4.8 2.2 1 1 1 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 PIK57491.1 - 1.2e-17 63.8 0.6 1.5e-17 63.5 0.6 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Ribonuclease_T2 PF00445.18 PIK57492.1 - 4.9e-38 131.2 0.7 6.1e-38 130.9 0.7 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Eapp_C PF10238.9 PIK57493.1 - 3e-53 179.9 2.0 3e-53 179.9 2.0 2.1 2 1 0 2 2 2 1 E2F-associated phosphoprotein C1_4 PF07975.12 PIK57493.1 - 0.011 15.9 0.3 0.16 12.2 0.1 2.7 3 0 0 3 3 3 0 TFIIH C1-like domain IBR PF01485.21 PIK57493.1 - 0.027 14.7 0.9 2.3 8.5 0.1 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Yippee-Mis18 PF03226.14 PIK57493.1 - 2.3 8.5 5.5 27 5.0 5.6 2.3 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PX PF00787.24 PIK57494.1 - 4.8e-17 62.0 0.2 1.1e-16 60.8 0.2 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 PIK57494.1 - 2e-15 57.0 21.8 3.1e-11 43.3 7.7 2.6 2 1 1 3 3 3 2 Vps5 C terminal like BAR PF03114.18 PIK57494.1 - 1.1e-05 25.2 15.8 0.00023 20.9 10.6 2.3 2 0 0 2 2 2 2 BAR domain Latarcin PF10279.9 PIK57494.1 - 0.008 16.6 4.2 0.008 16.6 4.2 2.6 2 0 0 2 2 2 1 Latarcin precursor SHOCT PF09851.9 PIK57494.1 - 0.016 15.0 0.8 0.069 12.9 0.8 2.2 1 0 0 1 1 1 0 Short C-terminal domain ChaC PF04752.12 PIK57495.1 - 3.2e-64 216.3 0.0 3.6e-64 216.1 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 PIK57495.1 - 1.4e-05 25.7 0.0 1.9e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK57495.1 - 0.0029 18.0 0.0 0.0041 17.5 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family PHF12_MRG_bd PF16737.5 PIK57495.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain Phosphorylase PF00343.20 PIK57496.1 - 0 1062.6 0.0 0 1062.4 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase rpo132 PF12415.8 PIK57496.1 - 0.21 10.9 3.1 0.49 9.7 0.2 2.4 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase EGF PF00008.27 PIK57497.1 - 2.1e-59 197.3 147.8 1.9e-08 34.4 8.0 11.7 12 0 0 12 12 12 10 EGF-like domain hEGF PF12661.7 PIK57497.1 - 1.3e-44 149.3 119.4 1.3e-07 31.9 0.9 12.8 12 0 0 12 12 12 10 Human growth factor-like EGF EGF_CA PF07645.15 PIK57497.1 - 6.1e-22 77.5 146.3 0.0099 16.1 10.9 11.2 4 3 7 11 11 11 10 Calcium-binding EGF domain EGF_2 PF07974.13 PIK57497.1 - 1.3e-12 47.8 166.1 0.0035 17.7 9.2 11.7 11 0 0 11 11 11 8 EGF-like domain EGF_3 PF12947.7 PIK57497.1 - 6e-11 42.4 125.1 0.0022 18.2 6.0 12.2 7 4 4 11 11 11 8 EGF domain Plasmod_Pvs28 PF06247.11 PIK57497.1 - 0.023 15.0 2.3 0.023 15.0 2.3 10.7 7 4 3 10 10 10 0 Pvs28 EGF domain cEGF PF12662.7 PIK57497.1 - 0.19 11.7 0.1 0.19 11.7 0.1 12.2 11 2 0 11 11 11 0 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK57497.1 - 0.95 9.8 133.9 0.48 10.7 7.8 11.4 7 4 4 11 11 11 0 Coagulation Factor Xa inhibitory site Histone PF00125.24 PIK57498.1 - 1.2e-47 161.5 1.0 1.6e-47 161.1 1.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK57498.1 - 5.5e-05 23.3 0.2 0.00031 20.8 0.0 2.0 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 PIK57498.1 - 0.00045 20.6 0.0 0.00077 19.8 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 PIK57498.1 - 0.11 12.8 0.3 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Tap-RNA_bind PF09162.10 PIK57499.1 - 4.1e-28 97.0 0.1 8.2e-28 96.1 0.1 1.5 1 0 0 1 1 1 1 Tap, RNA-binding TAP_C PF03943.13 PIK57499.1 - 6.9e-14 51.2 0.0 1.3e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 PIK57499.1 - 7.4e-10 39.4 0.8 3.2e-09 37.4 0.8 2.0 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_9 PF14580.6 PIK57499.1 - 0.026 14.0 0.3 0.046 13.2 0.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_8 PF13855.6 PIK57499.1 - 0.054 13.3 7.4 0.15 11.9 7.4 1.8 1 1 0 1 1 1 0 Leucine rich repeat LRR_4 PF12799.7 PIK57499.1 - 4.4 7.9 10.8 8.8 6.9 6.7 2.5 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) NT-C2 PF10358.9 PIK57500.1 - 7.6e-21 74.4 0.1 1.3e-20 73.6 0.1 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins CH PF00307.31 PIK57501.1 - 1.5e-18 66.9 0.5 2.7e-17 62.9 0.0 2.5 2 1 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK57501.1 - 1.7e-05 24.5 0.0 3.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 PIK57501.1 - 0.026 14.6 0.0 0.065 13.4 0.0 1.7 1 0 0 1 1 1 0 CH-like domain in sperm protein DUF3037 PF11236.8 PIK57501.1 - 0.099 13.1 2.9 0.27 11.7 2.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) TF_Otx PF03529.13 PIK57502.1 - 0.00019 21.7 6.2 0.00019 21.7 6.2 2.2 1 1 1 2 2 2 2 Otx1 transcription factor Glyco_transf_10 PF00852.19 PIK57503.1 - 4.2e-48 163.4 1.5 5.3e-48 163.1 1.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term LRR_6 PF13516.6 PIK57504.1 - 8.4e-22 75.3 19.1 5.9e-06 25.9 0.5 7.2 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 PIK57504.1 - 3.3e-05 23.8 1.6 4.3 8.3 0.0 5.6 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 PIK57504.1 - 0.00058 20.2 9.7 0.04 14.3 1.3 4.1 1 1 3 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57504.1 - 0.028 14.2 16.2 5.4 6.9 4.3 5.0 1 1 3 5 5 5 0 Leucine rich repeat FTH PF01827.27 PIK57504.1 - 0.057 13.2 0.7 15 5.3 0.0 3.3 3 0 0 3 3 3 0 FTH domain rve PF00665.26 PIK57505.1 - 2e-23 82.8 0.0 3.7e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK57505.1 - 2.4e-18 66.0 1.0 6.3e-18 64.6 1.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK57505.1 - 0.00096 19.3 0.6 0.0021 18.2 0.6 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK57505.1 - 0.0093 15.7 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK57505.1 - 0.038 14.5 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RVT_1 PF00078.27 PIK57506.1 - 6.5e-11 42.2 0.0 7.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ion_trans_2 PF07885.16 PIK57507.1 - 2.7e-15 56.1 5.1 4.1e-15 55.5 5.1 1.2 1 0 0 1 1 1 1 Ion channel DUF4834 PF16118.5 PIK57507.1 - 0.039 14.9 0.1 0.086 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TEX29 PF15839.5 PIK57507.1 - 0.049 14.2 0.6 0.049 14.2 0.6 2.0 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein Pkinase PF00069.25 PIK57508.1 - 6.8e-13 48.6 0.0 8.7e-10 38.4 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57508.1 - 6.9e-05 22.3 0.0 9.9e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 PIK57510.1 - 2.5e-14 53.1 0.8 5.4e-14 52.0 0.8 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain rve PF00665.26 PIK57511.1 - 1.9e-15 57.1 0.0 3.1e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain PX PF00787.24 PIK57511.1 - 9e-11 41.8 0.4 2.1e-10 40.6 0.4 1.6 1 0 0 1 1 1 1 PX domain rve_3 PF13683.6 PIK57511.1 - 6.7e-09 35.4 0.1 2.4e-08 33.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK57511.1 - 0.002 18.2 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain FERM_M PF00373.18 PIK57512.1 - 3.3e-18 66.2 0.2 3.3e-18 66.2 0.2 2.9 3 1 0 3 3 3 1 FERM central domain FERM_C PF09380.10 PIK57512.1 - 1.2e-13 51.3 0.1 2.9e-13 50.0 0.1 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 PIK57512.1 - 5.4e-13 48.7 0.1 1.4e-12 47.4 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain DUF1349 PF07081.11 PIK57512.1 - 0.003 17.3 0.1 0.018 14.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1349) DUF4549 PF15082.6 PIK57512.1 - 0.054 13.3 0.1 0.16 11.7 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) PLAC8 PF04749.17 PIK57514.1 - 3.8e-14 53.5 11.3 5.6e-14 52.9 11.3 1.3 1 0 0 1 1 1 1 PLAC8 family dCMP_cyt_deam_1 PF00383.23 PIK57515.1 - 4.8e-15 55.3 0.1 3.9e-14 52.4 0.1 2.2 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 PIK57515.1 - 1.6e-10 40.9 0.0 2.9e-08 33.6 0.0 2.3 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 PIK57515.1 - 0.0087 16.1 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Bd3614-like deaminase Sulfatase PF00884.23 PIK57516.1 - 1e-12 48.1 0.0 1e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Globin PF00042.22 PIK57517.1 - 4e-07 30.6 0.0 5.7e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Globin HSBP1 PF06825.12 PIK57517.1 - 0.072 13.0 1.0 0.38 10.6 0.6 2.2 1 1 1 2 2 2 0 Heat shock factor binding protein 1 EPTP PF03736.17 PIK57518.1 - 7.8e-31 105.8 16.2 7.8e-06 25.8 0.0 6.9 6 0 0 6 6 6 6 EPTP domain FAF PF11250.8 PIK57519.1 - 2.8e-05 24.3 36.3 13 6.1 0.1 9.2 9 0 0 9 9 9 9 Fantastic Four meristem regulator DUF294_C PF10335.9 PIK57519.1 - 0.065 13.0 0.9 91 2.8 0.0 4.0 2 1 5 7 7 7 0 Putative nucleotidyltransferase substrate binding domain DUF1780 PF08682.10 PIK57519.1 - 0.65 9.6 4.4 37 3.9 0.1 3.7 1 1 2 4 4 4 0 Putative endonuclease, protein of unknown function (DUF1780) Actin PF00022.19 PIK57520.1 - 3.9e-20 71.8 0.0 1.7e-17 63.1 0.0 2.0 1 1 0 1 1 1 1 Actin Actin PF00022.19 PIK57521.1 - 1.8e-19 69.6 0.0 2.5e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Actin S-methyl_trans PF02574.16 PIK57522.1 - 2.3e-19 70.2 0.0 2.8e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase AP_endonuc_2 PF01261.24 PIK57522.1 - 0.017 14.6 0.0 1.1 8.6 0.0 2.2 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel S-methyl_trans PF02574.16 PIK57523.1 - 3.9e-43 148.2 0.0 4.9e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Prion PF00377.18 PIK57524.1 - 0.33 10.8 2.7 2.3 8.1 0.3 2.3 2 0 0 2 2 2 0 Prion/Doppel alpha-helical domain DDE_Tnp_ISL3 PF01610.17 PIK57527.1 - 0.073 12.8 4.2 0.37 10.5 4.2 1.9 1 1 0 1 1 1 0 Transposase Herpes_env PF01673.18 PIK57528.1 - 0.054 12.4 0.0 0.086 11.7 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Ephrin_rec_like PF07699.13 PIK57528.1 - 0.11 12.3 1.7 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 Putative ephrin-receptor like VWC PF00093.18 PIK57529.1 - 3e-08 33.8 30.0 0.00027 21.2 9.5 3.0 3 0 0 3 3 3 2 von Willebrand factor type C domain CFC PF09443.10 PIK57529.1 - 0.0029 17.4 9.8 0.37 10.7 1.5 2.6 2 0 0 2 2 2 2 Cripto_Frl-1_Cryptic (CFC) TILa PF12714.7 PIK57529.1 - 0.02 14.8 23.9 0.2 11.7 6.4 2.5 2 0 0 2 2 2 0 TILa domain DUF4083 PF13314.6 PIK57529.1 - 0.1 12.5 0.4 0.18 11.8 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Fibrinogen_C PF00147.18 PIK57530.1 - 4e-51 173.9 11.7 5.5e-51 173.5 11.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57530.1 - 1.2e-06 28.4 12.0 1.2e-06 28.4 12.0 3.2 2 1 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK57530.1 - 0.0052 17.0 14.5 0.0052 17.0 14.5 4.1 3 2 1 4 4 4 1 EGF domain TIL PF01826.17 PIK57530.1 - 0.0054 17.0 13.4 0.0054 17.0 13.4 3.1 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Exo_endo_phos_2 PF14529.6 PIK57531.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase IHABP4_N PF16174.5 PIK57531.1 - 0.04 14.5 0.1 0.1 13.2 0.1 1.7 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal p450 PF00067.22 PIK57532.1 - 4.2e-78 263.1 0.0 1.6e-47 162.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Peptidase_M3 PF01432.20 PIK57533.1 - 0.042 13.1 10.3 0.073 12.3 10.3 1.3 1 0 0 1 1 1 0 Peptidase family M3 7tm_1 PF00001.21 PIK57534.1 - 5.2e-22 78.4 2.1 6.4e-22 78.1 2.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK57534.1 - 4.5e-07 29.7 6.5 7.1e-07 29.1 6.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK57534.1 - 0.0038 16.6 3.1 0.0056 16.1 3.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Y_phosphatase PF00102.27 PIK57535.1 - 1e-69 234.7 5.7 1.1e-41 142.9 0.1 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK57535.1 - 2.9e-05 23.9 0.5 0.0079 16.0 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK57535.1 - 0.00079 19.6 0.0 0.0025 17.9 0.0 1.9 1 0 0 1 1 1 1 Inositol hexakisphosphate Stevor PF17410.2 PIK57535.1 - 0.0059 16.2 0.1 0.013 15.1 0.1 1.5 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 PIK57535.1 - 0.053 12.3 0.0 0.094 11.5 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4750 PF15938.5 PIK57535.1 - 5.7 6.7 6.0 13 5.5 6.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) fn3 PF00041.21 PIK57536.1 - 1.5e-24 86.1 6.5 1.9e-13 50.6 0.1 3.3 3 1 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57536.1 - 1.1e-08 35.6 0.6 2e-05 25.1 0.1 2.9 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK57536.1 - 0.00058 20.0 3.0 0.015 15.5 0.5 3.5 3 2 0 3 3 3 1 Fibronectin type III domain Y_phosphatase PF00102.27 PIK57538.1 - 5.7e-73 245.4 5.1 6.1e-28 98.0 0.1 3.1 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK57538.1 - 3.1e-09 36.7 0.4 0.00078 19.3 0.0 2.7 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK57538.1 - 1.1e-06 28.9 1.0 0.02 14.9 0.1 2.3 1 1 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK57538.1 - 9.5e-06 25.8 1.7 0.0052 16.9 0.0 3.2 2 1 0 2 2 2 2 Inositol hexakisphosphate Myotub-related PF06602.14 PIK57538.1 - 0.011 14.7 0.6 0.6 9.0 0.5 2.6 2 1 0 2 2 2 0 Myotubularin-like phosphatase domain CDKN3 PF05706.12 PIK57538.1 - 0.033 13.8 0.0 2.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 PIK57538.1 - 0.047 13.3 3.1 2.6 7.6 0.1 3.2 2 2 1 3 3 3 0 Tyrosine phosphatase family Aminotran_5 PF00266.19 PIK57539.1 - 4.5e-26 91.7 0.0 5.6e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK57539.1 - 0.0009 18.5 0.0 0.0011 18.2 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II EF-hand_1 PF00036.32 PIK57540.1 - 1.5e-42 140.0 10.8 8e-10 37.6 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 PIK57540.1 - 6.8e-36 122.6 3.3 2.5e-18 66.3 0.9 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK57540.1 - 3.7e-33 113.1 10.9 2e-15 56.4 0.6 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 PIK57540.1 - 2.8e-30 101.6 5.6 1.7e-09 36.8 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK57540.1 - 4.4e-27 92.3 8.3 9.8e-07 28.0 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 PIK57540.1 - 1.7e-15 57.1 0.2 3.5e-09 36.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 PIK57540.1 - 3.6e-10 39.7 0.3 5.9e-05 23.0 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK57540.1 - 7.4e-08 32.7 0.0 0.0084 16.4 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 PIK57540.1 - 2.3e-06 28.4 0.0 0.00081 20.2 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 PIK57540.1 - 2.3e-05 24.3 0.0 0.057 13.4 0.0 3.1 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 PIK57540.1 - 0.0002 21.4 0.6 0.0016 18.5 0.1 2.4 2 2 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 PIK57540.1 - 0.00045 20.4 4.1 0.077 13.2 0.3 3.0 1 1 1 2 2 2 2 Dockerin type I domain DUF1103 PF06513.11 PIK57540.1 - 0.0012 18.5 2.9 0.0013 18.4 2.9 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF3349 PF11829.8 PIK57540.1 - 0.0015 19.2 0.4 1 10.1 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 PIK57540.1 - 0.0017 18.8 0.0 1.7 9.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) Caleosin PF05042.13 PIK57540.1 - 0.0032 17.4 0.8 0.73 9.8 0.0 3.3 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 PIK57540.1 - 0.0083 16.4 1.7 2.1 8.7 0.1 2.7 3 1 0 3 3 2 1 RNA polymerase Rpb4 TerB PF05099.13 PIK57540.1 - 0.011 15.7 0.7 1.1 9.2 0.0 2.4 1 1 1 2 2 2 0 Tellurite resistance protein TerB Poly_export PF02563.16 PIK57540.1 - 0.013 15.7 0.1 0.38 11.0 0.0 2.9 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein DUF5580 PF17743.1 PIK57540.1 - 0.021 13.4 0.0 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) MotA_activ PF09114.10 PIK57540.1 - 0.025 14.7 0.2 0.6 10.3 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_2 PF13623.6 PIK57540.1 - 0.028 14.3 0.8 1.2 9.0 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain dCache_2 PF08269.11 PIK57540.1 - 0.04 13.1 0.1 3.5 6.7 0.0 2.2 1 1 0 2 2 2 0 Cache domain DUF2267 PF10025.9 PIK57540.1 - 0.068 13.4 0.0 0.3 11.4 0.0 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) Spore_III_AB PF09548.10 PIK57540.1 - 0.091 12.9 0.6 0.27 11.3 0.5 1.8 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) CMD PF02627.20 PIK57540.1 - 0.14 12.2 0.3 9.9 6.3 0.0 2.7 3 1 0 3 3 2 0 Carboxymuconolactone decarboxylase family TetR_C_7 PF14246.6 PIK57540.1 - 0.16 12.0 0.0 10 6.2 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain PPP4R2 PF09184.11 PIK57541.1 - 0.0011 18.7 8.8 0.0011 18.7 8.8 1.9 2 0 0 2 2 2 1 PPP4R2 NOA36 PF06524.12 PIK57541.1 - 0.0021 17.4 20.3 0.005 16.2 20.3 1.6 1 0 0 1 1 1 1 NOA36 protein FYDLN_acid PF09538.10 PIK57541.1 - 0.23 12.1 24.2 0.058 14.1 18.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RXT2_N PF08595.11 PIK57541.1 - 1 9.4 14.3 0.23 11.5 9.1 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 PIK57541.1 - 1.2 8.2 11.7 1.8 7.6 11.7 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein GCIP PF13324.6 PIK57541.1 - 4.7 6.7 11.4 9.4 5.8 11.4 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CCDC32 PF14989.6 PIK57542.1 - 2.3e-14 53.6 0.0 3.1e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing 32 PPPI_inhib PF14895.6 PIK57543.1 - 1.6e-20 73.6 0.0 7e-14 51.8 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 1 inhibitor Pkinase PF00069.25 PIK57544.1 - 1.7e-51 175.2 0.0 6.1e-51 173.3 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain C1_1 PF00130.22 PIK57544.1 - 5e-26 90.3 18.0 2.7e-13 49.6 7.4 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 PIK57544.1 - 6.8e-18 64.9 0.0 2.5e-17 63.0 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK57544.1 - 1.3e-07 31.3 0.0 2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.16 PIK57544.1 - 5.3e-06 26.7 16.1 0.00086 19.6 1.7 2.5 2 0 0 2 2 2 2 C1 domain Kdo PF06293.14 PIK57544.1 - 0.00027 20.3 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.6 PIK57544.1 - 0.017 15.1 14.7 0.2 11.6 1.5 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Pkinase_fungal PF17667.1 PIK57544.1 - 0.021 13.6 0.0 0.037 12.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PHD PF00628.29 PIK57544.1 - 0.059 13.3 18.4 1.1 9.2 2.7 2.6 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.6 PIK57544.1 - 4.6 6.9 10.3 18 5.0 0.5 2.8 2 0 0 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 PIK57544.1 - 5.5 7.0 15.0 1.9 8.5 1.4 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 SSF PF00474.17 PIK57545.1 - 3.4e-34 118.4 26.4 4.6e-19 68.6 19.0 2.2 2 0 0 2 2 2 2 Sodium:solute symporter family Gly-zipper_Omp PF13488.6 PIK57545.1 - 0.12 12.4 1.2 0.32 11.0 1.2 1.7 1 0 0 1 1 1 0 Glycine zipper VWC PF00093.18 PIK57546.1 - 4.2e-18 65.4 111.4 2.3e-05 24.6 13.2 6.3 6 0 0 6 6 6 6 von Willebrand factor type C domain fn3 PF00041.21 PIK57546.1 - 3.8e-12 46.4 7.7 0.0036 17.6 0.2 4.7 4 1 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK57546.1 - 0.00026 21.5 4.8 0.26 11.9 0.0 4.6 5 0 0 5 5 5 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 PIK57546.1 - 0.00041 20.7 0.3 7.1 7.1 0.0 4.4 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) TILa PF12714.7 PIK57546.1 - 0.0088 16.0 5.5 0.0088 16.0 5.5 7.6 7 1 1 8 8 8 5 TILa domain Big_5 PF13205.6 PIK57546.1 - 0.097 13.4 0.0 2.7 8.7 0.0 2.7 3 0 0 3 3 3 0 Bacterial Ig-like domain fn3_2 PF16893.5 PIK57546.1 - 0.4 10.9 1.9 0.75 10.0 0.4 2.2 2 0 0 2 2 2 0 Fibronectin type III domain FA_desaturase PF00487.24 PIK57547.1 - 4.3e-22 79.2 11.9 7.1e-22 78.5 11.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 PIK57547.1 - 1.3e-20 72.6 0.1 2.3e-20 71.8 0.1 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) HXXEE PF13787.6 PIK57547.1 - 0.087 13.6 0.2 0.087 13.6 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function with HXXEE motif EF-hand_7 PF13499.6 PIK57548.1 - 0.051 14.0 6.0 0.13 12.7 0.0 3.7 3 1 0 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.6 PIK57548.1 - 0.1 12.6 0.0 0.69 10.0 0.0 2.5 1 0 0 1 1 1 0 EF-hand domain THRAP3_BCLAF1 PF15440.6 PIK57548.1 - 4.4 6.2 51.4 6.1 5.7 51.4 1.2 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Fibrinogen_C PF00147.18 PIK57549.1 - 9.1e-34 117.2 8.9 1.1e-33 116.9 8.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RT_RNaseH PF17917.1 PIK57550.1 - 1.9e-34 118.1 0.1 4.6e-34 116.8 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK57550.1 - 4.5e-33 113.3 0.0 1.4e-32 111.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK57550.1 - 2.7e-29 102.3 0.1 4.7e-29 101.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) N-glycanase_N PF09112.10 PIK57550.1 - 0.054 13.3 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 Peptide-N-glycosidase F, N terminal EGF_3 PF12947.7 PIK57551.1 - 2.8e-11 43.4 25.2 6.2e-07 29.5 8.7 5.6 4 2 1 5 5 5 2 EGF domain Fibrinogen_C PF00147.18 PIK57551.1 - 9e-11 42.0 0.0 2.2e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57551.1 - 4.6e-10 39.3 14.2 3.7e-06 26.8 4.2 4.5 2 1 2 4 4 4 2 TILa domain TIL PF01826.17 PIK57551.1 - 0.0025 18.0 11.7 0.0025 18.0 11.7 4.5 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK57551.1 - 0.016 15.3 16.3 0.029 14.4 4.3 4.5 5 0 0 5 5 5 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK57551.1 - 0.036 14.4 44.6 0.036 14.4 8.5 5.3 3 2 1 4 4 4 0 EGF-like domain Caprin-1_C PF12287.8 PIK57551.1 - 0.23 11.6 3.0 0.27 11.3 0.6 1.9 1 1 1 2 2 2 0 Cytoplasmic activation/proliferation-associated protein-1 C term Fibrinogen_C PF00147.18 PIK57552.1 - 9.3e-51 172.7 9.6 2.1e-50 171.6 9.6 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57552.1 - 2.3e-09 37.0 29.9 3.3e-05 23.8 3.7 3.8 3 1 0 3 3 3 2 TILa domain EGF_3 PF12947.7 PIK57552.1 - 5.5e-08 32.9 41.5 0.00017 21.7 8.7 4.7 2 2 2 4 4 4 2 EGF domain EGF_MSP1_1 PF12946.7 PIK57552.1 - 1.6e-05 24.8 24.7 0.00047 20.2 5.5 3.5 3 0 0 3 3 3 2 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK57552.1 - 0.0044 17.4 31.7 0.01 16.2 7.8 4.1 3 2 0 3 3 3 2 EGF-like domain Fibrinogen_C PF00147.18 PIK57553.1 - 8.1e-55 186.0 2.2 6.4e-34 117.7 0.7 2.4 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK57553.1 - 0.00023 21.3 8.0 0.00023 21.3 8.0 4.1 3 0 0 3 3 3 1 EGF domain TIL PF01826.17 PIK57553.1 - 0.00029 21.0 35.7 0.0022 18.2 14.0 3.7 4 0 0 4 4 4 2 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK57553.1 - 0.0052 17.1 5.8 0.0052 17.1 5.8 6.3 6 2 0 6 6 6 1 EGF-like domain EFhand_Ca_insen PF08726.10 PIK57553.1 - 0.015 15.4 0.2 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Ca2+ insensitive EF hand G6PD_bact PF10786.9 PIK57553.1 - 0.021 14.4 0.1 6.5 6.2 0.0 2.3 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) DUF2846 PF11008.8 PIK57553.1 - 0.036 14.1 0.2 15 5.7 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2846) Fibrinogen_C PF00147.18 PIK57555.1 - 4.8e-52 177.0 18.7 1.4e-50 172.2 13.5 2.3 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57555.1 - 2.3e-05 24.2 5.5 2.3e-05 24.2 5.5 4.3 2 2 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK57555.1 - 9.5e-05 22.5 13.9 9.5e-05 22.5 13.9 4.6 3 1 1 4 4 4 1 EGF domain TIL PF01826.17 PIK57555.1 - 0.00085 19.5 13.0 0.00085 19.5 13.0 3.8 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK57555.1 - 0.0078 16.2 3.5 0.0078 16.2 3.5 3.4 4 0 0 4 4 4 1 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK57556.1 - 1.4e-57 195.1 15.8 1.9e-52 178.3 10.3 3.5 3 0 0 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK57556.1 - 1.4e-11 44.4 72.8 1.5e-05 25.1 8.4 7.2 5 2 2 7 7 7 3 EGF domain TILa PF12714.7 PIK57556.1 - 4.6e-10 39.3 30.8 5.2e-06 26.3 5.8 5.3 4 1 1 5 5 5 3 TILa domain TIL PF01826.17 PIK57556.1 - 0.012 15.9 12.7 0.012 15.9 12.7 6.0 3 1 2 5 5 5 0 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK57556.1 - 0.012 15.7 3.2 0.012 15.7 3.2 5.4 6 0 0 6 6 6 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK57556.1 - 0.026 14.9 59.1 0.3 11.5 8.0 6.5 4 1 0 4 4 4 0 EGF-like domain DUF4304 PF14137.6 PIK57556.1 - 1.8 8.8 4.1 61 3.8 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4304) PapB PF03333.13 PIK57556.1 - 2.4 8.2 8.3 8.2 6.5 0.2 2.9 3 0 0 3 3 3 0 Adhesin biosynthesis transcription regulatory protein Fibrinogen_C PF00147.18 PIK57557.1 - 2.9e-26 92.6 2.1 3.2e-26 92.5 2.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK57558.1 - 2.7e-22 79.7 0.2 3e-22 79.5 0.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK57560.1 - 4.8e-30 105.0 0.3 6.9e-30 104.5 0.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK57560.1 - 1.7e-05 24.7 14.0 1.7e-05 24.7 14.0 2.2 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK57560.1 - 2.4e-05 24.4 13.4 2.4e-05 24.4 13.4 2.5 2 1 0 2 2 2 1 EGF domain EGF PF00008.27 PIK57560.1 - 0.041 14.2 5.7 0.041 14.2 5.7 2.4 2 1 1 3 3 3 0 EGF-like domain VWC PF00093.18 PIK57560.1 - 0.64 10.4 16.7 3.2 8.1 16.7 2.0 1 1 0 1 1 1 0 von Willebrand factor type C domain Med18 PF09637.10 PIK57561.1 - 0.017 15.0 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 Med18 protein RVT_1 PF00078.27 PIK57562.1 - 1.7e-11 44.0 0.0 2.3e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ARL6IP6 PF15062.6 PIK57563.1 - 6.9e-15 54.9 0.4 1.2e-14 54.2 0.4 1.4 1 0 0 1 1 1 1 Haemopoietic lineage transmembrane helix PrmA PF06325.13 PIK57564.1 - 1.8e-11 44.0 0.1 2.5e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 PIK57564.1 - 3e-11 43.1 0.0 4.5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 PIK57564.1 - 3.4e-10 39.9 0.1 4.1e-10 39.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK57564.1 - 6.7e-08 33.1 0.1 1.4e-07 32.1 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK57564.1 - 2.6e-07 30.4 0.0 3.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 PIK57564.1 - 2.1e-05 25.2 0.0 4.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 PIK57564.1 - 0.00034 20.3 1.3 0.0012 18.6 1.3 1.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 PIK57564.1 - 0.00089 18.9 0.1 0.0012 18.4 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 PIK57564.1 - 0.0053 17.4 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 PIK57564.1 - 0.0081 15.5 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase DUF43 PF01861.16 PIK57564.1 - 0.021 14.1 0.2 0.045 13.0 0.1 1.6 2 0 0 2 2 2 0 Branched-chain polyamine synthase A C-terminal domain Ubie_methyltran PF01209.18 PIK57564.1 - 0.035 13.4 0.3 0.056 12.8 0.1 1.4 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family N6-adenineMlase PF10237.9 PIK57564.1 - 0.042 13.7 0.1 0.05 13.4 0.1 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Methyltransf_4 PF02390.17 PIK57564.1 - 0.047 13.2 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DNA_methylase PF00145.17 PIK57564.1 - 0.069 12.5 0.2 0.13 11.6 0.1 1.5 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase PCMT PF01135.19 PIK57564.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fam20C PF06702.12 PIK57565.1 - 7.2e-62 209.1 0.1 1.4e-41 142.7 0.0 2.5 1 1 1 2 2 2 2 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 PIK57565.1 - 0.0034 16.3 0.5 0.011 14.7 0.0 1.9 2 0 0 2 2 2 1 FAM198 protein Laminin_N PF00055.17 PIK57565.1 - 0.22 11.1 2.1 1.2 8.7 0.2 2.1 2 0 0 2 2 2 0 Laminin N-terminal (Domain VI) DUF4449 PF14613.6 PIK57566.1 - 0.11 12.6 0.9 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) Sema PF01403.19 PIK57567.1 - 1.7e-17 63.3 1.2 1.6e-09 37.1 0.1 2.3 1 1 1 2 2 2 2 Sema domain ABC_tran PF00005.27 PIK57568.1 - 3e-11 44.0 0.0 4.7e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 PIK57568.1 - 1.5e-07 31.6 0.0 2.1e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_21 PF13304.6 PIK57570.1 - 9.4e-05 22.4 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 PIK57571.1 - 7e-22 78.0 13.0 1.4e-21 77.0 13.0 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 PIK57571.1 - 1.6e-19 70.8 0.0 3.6e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_15 PF13175.6 PIK57571.1 - 0.0037 17.0 0.0 0.006 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 PIK57571.1 - 0.0042 17.6 0.2 0.0083 16.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain ABC2_membrane_2 PF12679.7 PIK57571.1 - 0.0076 15.6 6.2 0.015 14.6 6.2 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_29 PF13555.6 PIK57571.1 - 0.028 14.2 0.2 0.059 13.1 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 PIK57571.1 - 0.065 13.0 0.1 0.23 11.2 0.1 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SRP54 PF00448.22 PIK57571.1 - 0.21 11.2 0.2 0.33 10.6 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF3677 PF12432.8 PIK57572.1 - 4.6e-30 103.8 4.7 1.8e-29 101.9 2.2 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3677) MMM1 PF10296.9 PIK57575.1 - 7.4e-06 25.2 0.2 0.0003 19.9 0.0 2.9 2 1 2 4 4 4 1 Maintenance of mitochondrial morphology protein 1 RRM_1 PF00076.22 PIK57576.1 - 1.8e-16 59.7 0.0 2.7e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 PIK57576.1 - 0.0068 16.4 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 Nup35_RRM_2 PF14605.6 PIK57576.1 - 0.012 15.6 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF572 PF04502.13 PIK57576.1 - 0.048 13.3 11.8 0.066 12.8 11.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Presenilin PF01080.17 PIK57576.1 - 1.3 7.7 10.2 2.1 7.0 10.2 1.5 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 PIK57576.1 - 2.6 7.2 4.9 3.7 6.7 4.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AMP-binding_C PF13193.6 PIK57577.1 - 7.2e-17 62.1 2.3 6.7e-11 43.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK57578.1 - 1.4e-68 231.5 0.0 1.5e-68 231.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme M20_dimer PF07687.14 PIK57580.1 - 1.2e-11 44.5 0.0 2.6e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 PIK57580.1 - 6.9e-09 35.7 0.1 1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 ENTH PF01417.20 PIK57581.1 - 2.8e-36 124.3 0.5 4.6e-36 123.6 0.5 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 PIK57581.1 - 0.0017 17.4 0.1 0.0028 16.7 0.1 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 PIK57581.1 - 0.0019 18.1 0.2 0.0051 16.7 0.1 1.7 2 0 0 2 2 2 1 VHS domain UIM PF02809.20 PIK57581.1 - 0.021 14.7 5.5 0.021 14.7 5.5 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif UCR_UQCRX_QCR9 PF05365.12 PIK57581.1 - 0.065 13.2 0.3 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Dus PF01207.17 PIK57582.1 - 1.2e-74 251.2 0.1 2e-74 250.5 0.1 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SOR_SNZ PF01680.17 PIK57582.1 - 9.8e-06 25.5 0.6 0.00011 22.1 0.1 2.3 1 1 1 2 2 2 1 SOR/SNZ family His_biosynth PF00977.21 PIK57582.1 - 0.0018 17.8 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 PIK57582.1 - 0.0053 16.2 0.0 0.031 13.7 0.0 1.9 1 1 1 2 2 2 1 Nitronate monooxygenase G3P_antiterm PF04309.12 PIK57582.1 - 0.073 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator NanE PF04131.14 PIK57582.1 - 0.13 11.4 0.1 0.28 10.4 0.1 1.5 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 PIK57582.1 - 0.17 10.9 0.1 0.34 9.9 0.1 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase ThiG PF05690.14 PIK57582.1 - 0.17 11.2 0.1 0.29 10.4 0.1 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG CBM_3 PF00942.18 PIK57583.1 - 0.11 13.0 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Cellulose binding domain Fez1 PF06818.15 PIK57584.1 - 0.015 15.7 33.3 0.48 10.9 13.7 2.2 1 1 1 2 2 2 0 Fez1 Herpes_BLRF2 PF05812.12 PIK57584.1 - 0.089 12.9 20.0 0.27 11.4 5.3 3.7 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein HAP1_N PF04849.13 PIK57584.1 - 0.25 10.5 33.9 0.27 10.4 24.1 2.5 2 1 0 2 2 2 0 HAP1 N-terminal conserved region GIT_CC PF16559.5 PIK57584.1 - 2.2 8.2 15.1 0.14 12.0 2.8 3.7 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2680 PF10925.8 PIK57584.1 - 5.7 7.0 11.1 14 5.8 0.6 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) DUF16 PF01519.16 PIK57584.1 - 6.3 7.3 24.5 8.1 7.0 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function DUF16 DUF4407 PF14362.6 PIK57584.1 - 9.1 5.5 23.5 9.1 5.5 9.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) LUC7 PF03194.15 PIK57585.1 - 7e-84 281.4 28.3 7e-84 281.4 28.3 3.0 1 1 1 2 2 2 1 LUC7 N_terminus DUF2203 PF09969.9 PIK57585.1 - 0.074 13.8 0.5 0.074 13.8 0.5 4.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Death PF00531.22 PIK57586.1 - 1e-05 25.6 0.2 1.6e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 Death domain CARD PF00619.21 PIK57586.1 - 0.014 15.4 0.1 0.034 14.2 0.0 1.7 2 0 0 2 2 2 0 Caspase recruitment domain YqzE PF14038.6 PIK57586.1 - 5.1 7.2 6.8 83 3.3 5.4 2.3 2 0 0 2 2 2 0 YqzE-like protein HA2 PF04408.23 PIK57587.1 - 9.9e-16 58.0 0.0 1.7e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK57587.1 - 8.6e-09 35.7 0.0 1.9e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK57587.1 - 2.6e-05 24.1 0.0 5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase TraG_N PF07916.11 PIK57587.1 - 0.017 14.0 0.0 0.024 13.5 0.0 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Flavi_DEAD PF07652.14 PIK57587.1 - 0.087 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Na_trans_assoc PF06512.13 PIK57588.1 - 0.11 12.8 5.6 0.16 12.2 5.6 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Ank_2 PF12796.7 PIK57589.1 - 4.6e-26 91.2 0.1 2.4e-14 53.7 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK57589.1 - 1.3e-25 89.4 0.6 1.6e-09 38.1 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK57589.1 - 9.2e-20 70.5 1.4 5.5e-08 32.9 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK57589.1 - 4.8e-19 66.5 0.3 6.8e-05 23.0 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 PIK57589.1 - 8.9e-18 63.9 1.5 7.4e-07 29.3 0.2 3.6 3 0 0 3 3 3 3 Ankyrin repeat PLAT PF01477.23 PIK57589.1 - 3.3e-15 56.7 0.0 6.4e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain ELO PF01151.18 PIK57590.1 - 3.7e-63 213.4 20.2 4.2e-63 213.2 20.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 PIK57591.1 - 1.7e-23 83.4 2.5 2e-23 83.3 2.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family COX15-CtaA PF02628.15 PIK57591.1 - 0.00056 19.1 1.0 0.00069 18.8 1.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF4149 PF13664.6 PIK57591.1 - 0.0059 16.9 0.0 0.0083 16.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4149) YesK PF14150.6 PIK57591.1 - 0.025 14.7 2.0 0.026 14.7 0.8 1.7 2 0 0 2 2 2 0 YesK-like protein Raf1_HTH PF18579.1 PIK57591.1 - 0.12 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain ELO PF01151.18 PIK57592.1 - 8.2e-63 212.2 27.1 9.7e-63 212.0 27.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 PIK57593.1 - 8.9e-61 205.6 25.8 1e-60 205.4 25.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RVT_1 PF00078.27 PIK57594.1 - 2.6e-06 27.1 0.0 5.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF656 PF04920.12 PIK57594.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF656) RVT_1 PF00078.27 PIK57595.1 - 0.026 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK57596.1 - 2.7e-07 30.4 0.8 4.8e-07 29.7 0.8 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK57596.1 - 0.0031 17.1 0.0 0.0048 16.4 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TMEM154 PF15102.6 PIK57597.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Shisa PF13908.6 PIK57597.1 - 0.037 14.3 8.7 0.2 11.9 0.0 3.5 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK57597.1 - 0.056 14.3 0.3 0.14 13.1 0.3 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PMP1_2 PF08114.11 PIK57597.1 - 0.11 12.2 4.3 0.21 11.3 4.3 1.4 1 0 0 1 1 1 0 ATPase proteolipid family DUF4381 PF14316.6 PIK57597.1 - 0.12 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) MHYT PF03707.16 PIK57597.1 - 0.51 10.5 3.1 1.5 9.1 1.0 2.5 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat TMC PF07810.13 PIK57598.1 - 3.6e-13 50.1 0.6 3.6e-13 50.1 0.6 3.4 4 0 0 4 4 4 1 TMC domain TrbC PF04956.13 PIK57598.1 - 0.18 12.1 0.1 0.18 12.1 0.1 2.5 2 0 0 2 2 2 0 TrbC/VIRB2 family RR_TM4-6 PF06459.12 PIK57598.1 - 6.7 6.5 6.7 0.62 9.8 1.9 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FKBP_C PF00254.28 PIK57599.1 - 1.3e-12 47.9 0.0 1.4e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LAP1C PF05609.12 PIK57600.1 - 0.00062 19.0 2.4 0.00077 18.7 2.4 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) SDA1 PF05285.12 PIK57600.1 - 0.0042 16.6 28.5 0.0049 16.3 28.5 1.1 1 0 0 1 1 1 1 SDA1 DUF481 PF04338.12 PIK57600.1 - 0.0047 17.0 3.7 0.38 10.8 3.7 2.4 1 1 0 1 1 1 1 Protein of unknown function, DUF481 Mpp10 PF04006.12 PIK57600.1 - 0.25 9.8 34.0 0.28 9.6 34.0 1.1 1 0 0 1 1 1 0 Mpp10 protein PCI PF01399.27 PIK57601.1 - 9.9e-19 67.8 0.1 9.9e-19 67.8 0.1 2.7 3 1 0 3 3 3 1 PCI domain RPN5_C PF18098.1 PIK57601.1 - 8e-17 61.1 9.8 2.2e-16 59.6 9.8 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain DUF1031 PF06275.11 PIK57601.1 - 0.013 15.8 1.3 0.043 14.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) TPR_19 PF14559.6 PIK57601.1 - 0.027 15.0 1.4 3.9 8.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SIX1_SD PF16878.5 PIK57601.1 - 0.056 14.0 0.4 0.27 11.8 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain DUF2203 PF09969.9 PIK57601.1 - 0.057 14.2 8.5 0.42 11.3 0.0 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) CLTH PF10607.9 PIK57601.1 - 1.3 8.9 11.2 6.5 6.6 8.3 3.3 1 1 2 3 3 3 0 CTLH/CRA C-terminal to LisH motif domain Ras PF00071.22 PIK57602.1 - 3.2e-61 205.7 0.1 3.9e-61 205.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57602.1 - 2.8e-34 117.9 0.1 4e-34 117.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57602.1 - 3.7e-15 55.8 0.0 4.6e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK57602.1 - 3e-08 33.3 0.1 3.7e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK57602.1 - 2.9e-05 23.7 0.4 7.7e-05 22.3 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 PIK57602.1 - 0.00012 22.1 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 PIK57602.1 - 0.00081 19.2 0.0 0.0015 18.3 0.0 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 PIK57602.1 - 0.0034 16.9 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 PIK57602.1 - 0.0043 17.0 0.4 0.55 10.1 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 PIK57602.1 - 0.032 13.5 0.2 0.078 12.2 0.2 1.6 1 1 0 1 1 1 0 Septin AAA_16 PF13191.6 PIK57602.1 - 0.047 14.1 0.1 0.081 13.3 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 PIK57602.1 - 0.048 13.4 0.2 0.07 12.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK57602.1 - 0.091 13.0 0.2 0.3 11.4 0.1 2.1 1 1 1 2 2 2 0 AAA domain AsnC_trans_reg2 PF17805.1 PIK57602.1 - 0.093 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 AsnC-like ligand binding domain AAA_7 PF12775.7 PIK57602.1 - 0.096 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Hpr_kinase_C PF07475.12 PIK57602.1 - 0.11 12.1 0.2 3.8 7.0 0.1 2.2 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain PH PF00169.29 PIK57604.1 - 1.5e-21 76.8 0.4 1.7e-10 41.3 0.1 3.4 2 0 0 2 2 2 2 PH domain GAS PF13851.6 PIK57604.1 - 0.0013 18.2 16.3 0.0013 18.2 16.3 8.8 2 1 6 9 9 9 4 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 PIK57604.1 - 0.0065 16.7 16.1 0.0065 16.7 16.1 11.1 4 2 6 10 10 10 4 Autophagy protein 16 (ATG16) Apyrase PF06079.11 PIK57605.1 - 3e-33 115.3 0.1 3.6e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 Apyrase Apyrase PF06079.11 PIK57606.1 - 1.9e-56 191.4 0.2 2.2e-56 191.2 0.2 1.0 1 0 0 1 1 1 1 Apyrase Complex1_LYR PF05347.15 PIK57607.1 - 2e-09 37.4 0.0 3.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 PIK57607.1 - 0.0013 19.4 0.2 0.0018 18.9 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Lipocalin_2 PF08212.12 PIK57608.1 - 1.1e-09 38.3 0.0 1.6e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain PCRF PF03462.18 PIK57610.1 - 0.048 13.5 0.1 0.14 12.0 0.1 1.7 1 1 1 2 2 2 0 PCRF domain Imm3 PF14425.6 PIK57610.1 - 0.076 13.1 0.8 0.98 9.5 0.0 2.3 2 0 0 2 2 2 0 Immunity protein Imm3 FliG_M PF14841.6 PIK57610.1 - 0.1 12.8 0.1 0.7 10.2 0.0 2.3 2 0 0 2 2 2 0 FliG middle domain Rx_N PF18052.1 PIK57612.1 - 0.0047 17.2 0.9 1.4 9.3 0.2 2.5 2 0 0 2 2 2 2 Rx N-terminal domain MSP1b PF03429.13 PIK57613.1 - 0.082 11.0 0.1 0.083 11.0 0.1 1.0 1 0 0 1 1 1 0 Major surface protein 1B DUF656 PF04920.12 PIK57614.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF656) Aldedh PF00171.22 PIK57616.1 - 1.2e-116 389.9 0.0 1.4e-116 389.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family V-set PF07686.17 PIK57617.1 - 5.5e-12 45.8 0.1 5.1e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK57617.1 - 2.1e-08 34.2 0.0 0.006 16.7 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK57617.1 - 1.4e-07 32.0 0.6 0.0061 17.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK57617.1 - 0.00063 19.8 0.0 0.31 11.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain SIM_C PF06621.12 PIK57617.1 - 0.14 12.2 0.0 2.3 8.2 0.0 2.0 2 0 0 2 2 2 0 Single-minded protein C-terminus NACHT PF05729.12 PIK57618.1 - 6.7e-16 58.6 0.0 1.7e-15 57.3 0.0 1.7 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 PIK57618.1 - 5.6e-07 29.0 0.0 9e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain C2-set_2 PF08205.12 PIK57618.1 - 4.1e-06 26.8 0.3 0.046 13.8 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain AAA_25 PF13481.6 PIK57618.1 - 0.0045 16.6 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK57618.1 - 0.0077 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain CD34_antigen PF06365.12 PIK57618.1 - 0.013 15.1 0.1 0.023 14.3 0.1 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family TMEM154 PF15102.6 PIK57618.1 - 0.016 15.1 0.6 0.03 14.2 0.6 1.4 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 PIK57618.1 - 0.019 15.9 0.4 0.12 13.2 0.1 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2561 PF10812.8 PIK57618.1 - 0.022 14.8 0.1 0.046 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) AAA_22 PF13401.6 PIK57618.1 - 0.032 14.5 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK57618.1 - 0.043 13.0 0.0 0.086 12.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ECSCR PF15820.5 PIK57618.1 - 0.063 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Adeno_E3_CR2 PF02439.15 PIK57618.1 - 0.087 12.6 7.0 0.16 11.7 7.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Shisa PF13908.6 PIK57618.1 - 0.091 13.0 0.5 0.16 12.2 0.5 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator GOLD_2 PF13897.6 PIK57618.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking UPF0489 PF12640.7 PIK57619.1 - 0.037 14.3 0.2 0.065 13.5 0.2 1.5 1 1 0 1 1 1 0 UPF0489 domain YqzE PF14038.6 PIK57619.1 - 1 9.4 3.1 8.2 6.5 0.2 2.3 2 0 0 2 2 2 0 YqzE-like protein PUF PF00806.19 PIK57620.1 - 2.8e-14 51.9 3.3 0.61 9.9 0.0 8.9 9 0 0 9 9 9 6 Pumilio-family RNA binding repeat DUF5097 PF17020.5 PIK57620.1 - 0.079 13.3 0.6 0.26 11.6 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) RcsD_ABL PF16359.5 PIK57620.1 - 0.13 12.5 1.4 0.35 11.0 0.1 2.4 3 0 0 3 3 3 0 RcsD-ABL domain RT_RNaseH_2 PF17919.1 PIK57621.1 - 7.7e-28 96.5 0.0 1.3e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57621.1 - 3.2e-25 88.4 0.0 4.8e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK57621.1 - 1.7e-17 63.2 1.1 3.4e-17 62.3 1.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK57621.1 - 7.7e-07 28.9 0.3 1.8e-06 27.7 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK57621.1 - 0.024 14.8 0.8 0.056 13.7 0.8 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Bclx_interact PF08945.10 PIK57622.1 - 0.53 10.1 3.3 1.3 8.8 3.3 1.6 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain zf-CCHC PF00098.23 PIK57623.1 - 0.049 13.7 1.6 0.079 13.1 1.6 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK57623.1 - 0.08 12.8 0.6 0.08 12.8 0.6 1.6 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 PIK57624.1 - 2.6e-29 102.3 0.2 5e-29 101.4 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK57624.1 - 6e-23 80.8 0.0 1.7e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57624.1 - 7.2e-10 39.1 0.0 2.2e-09 37.6 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase GEP5 PF17053.5 PIK57624.1 - 0.11 12.4 0.1 0.5 10.2 0.0 1.9 2 0 0 2 2 2 0 Genetic interactor of prohibitin 5 C8 PF08742.11 PIK57625.1 - 7.1e-15 55.2 5.1 7.1e-15 55.2 5.1 2.4 2 0 0 2 2 2 1 C8 domain TIL PF01826.17 PIK57625.1 - 8.7e-11 41.9 15.9 8.7e-11 41.9 15.9 3.1 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 PIK57626.1 - 1.8e-44 149.9 371.2 6.3e-11 42.4 14.1 19.8 17 3 1 18 18 12 12 von Willebrand factor type C domain VWD PF00094.25 PIK57626.1 - 4.8e-36 124.4 0.0 1.1e-35 123.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type D domain Ig_3 PF13927.6 PIK57626.1 - 2.3e-17 63.4 2.8 0.00071 20.1 0.0 7.3 7 0 0 7 7 7 2 Immunoglobulin domain I-set PF07679.16 PIK57626.1 - 7e-12 45.3 0.1 0.0033 17.5 0.0 5.9 6 0 0 6 6 6 2 Immunoglobulin I-set domain ig PF00047.25 PIK57626.1 - 5.2e-11 42.6 1.0 0.018 15.2 0.0 4.8 5 0 0 5 5 5 3 Immunoglobulin domain TILa PF12714.7 PIK57626.1 - 4.7e-07 29.7 25.1 2.1e-06 27.6 7.7 19.2 19 3 1 21 21 12 5 TILa domain V-set PF07686.17 PIK57626.1 - 1.5e-06 28.4 1.3 0.24 11.6 0.1 4.3 4 1 0 4 4 4 2 Immunoglobulin V-set domain FXa_inhibition PF14670.6 PIK57626.1 - 1.5e-05 25.2 8.8 1.5e-05 25.2 8.8 18.6 18 5 1 19 19 7 2 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 PIK57626.1 - 4.9e-05 23.6 27.0 0.00035 20.9 7.0 23.2 24 2 2 26 26 21 12 EGF-like domain EGF_Tenascin PF18720.1 PIK57626.1 - 0.0014 18.6 7.3 0.0014 18.6 7.3 17.3 16 0 0 16 16 12 6 Tenascin EGF domain cEGF PF12662.7 PIK57626.1 - 0.002 18.0 0.8 0.002 18.0 0.8 15.4 18 0 0 18 18 16 3 Complement Clr-like EGF-like EGF PF00008.27 PIK57626.1 - 0.0036 17.6 297.0 0.015 15.6 8.4 21.3 21 0 0 21 21 17 14 EGF-like domain hEGF PF12661.7 PIK57626.1 - 0.012 16.2 5.6 0.012 16.2 5.6 22.5 23 0 0 23 23 17 0 Human growth factor-like EGF Ig_3 PF13927.6 PIK57627.1 - 7.5e-21 74.5 0.5 9.3e-05 23.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK57627.1 - 1.2e-15 57.3 0.0 3.4e-05 23.8 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK57627.1 - 3.3e-13 49.8 2.4 0.0013 19.0 0.0 5.4 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 PIK57627.1 - 3e-10 40.3 0.7 0.19 11.9 0.0 5.0 6 1 1 7 7 7 3 Immunoglobulin V-set domain ig PF00047.25 PIK57627.1 - 1.4e-09 38.0 0.0 0.7 10.1 0.0 5.3 5 1 0 5 5 5 3 Immunoglobulin domain EGF PF00008.27 PIK57627.1 - 1.1e-08 35.2 90.3 0.00044 20.5 7.3 7.8 8 0 0 8 8 8 5 EGF-like domain EGF_2 PF07974.13 PIK57627.1 - 1.1e-08 35.3 91.2 0.0049 17.2 7.3 6.6 6 0 0 6 6 6 4 EGF-like domain Ig_6 PF18452.1 PIK57627.1 - 3.9e-05 23.1 0.7 0.12 11.9 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain hEGF PF12661.7 PIK57627.1 - 5.4e-05 23.7 84.6 0.0025 18.4 4.2 8.6 8 0 0 8 8 8 5 Human growth factor-like EGF Izumo-Ig PF16706.5 PIK57627.1 - 0.0041 17.2 0.1 2 8.5 0.1 2.9 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_3 PF13927.6 PIK57628.1 - 5.5e-15 55.7 0.0 6e-06 26.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK57628.1 - 8e-14 51.6 0.0 3.7e-06 27.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK57628.1 - 2.4e-09 37.1 0.0 0.013 15.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK57628.1 - 1.9e-08 34.5 0.0 0.0032 17.8 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain EGF_2 PF07974.13 PIK57628.1 - 5.1e-07 29.9 40.8 0.0036 17.7 7.9 3.9 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.27 PIK57628.1 - 5.6e-07 29.8 38.1 0.0063 16.8 7.6 4.7 4 0 0 4 4 4 3 EGF-like domain V-set PF07686.17 PIK57628.1 - 2.5e-06 27.6 0.1 0.067 13.4 0.0 3.2 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK57629.1 - 5.6e-78 257.6 17.9 7.4e-07 29.7 0.2 13.3 13 0 0 13 13 13 12 Immunoglobulin domain I-set PF07679.16 PIK57629.1 - 5e-65 215.6 0.0 7.2e-07 29.2 0.0 13.1 13 0 0 13 13 13 11 Immunoglobulin I-set domain ig PF00047.25 PIK57629.1 - 1.4e-61 204.6 3.4 1.8e-05 24.8 0.0 12.9 13 1 0 13 13 13 11 Immunoglobulin domain Ig_2 PF13895.6 PIK57629.1 - 1.5e-40 137.3 10.2 0.00013 22.3 0.0 13.4 12 1 1 13 13 13 8 Immunoglobulin domain V-set PF07686.17 PIK57629.1 - 2.4e-38 130.6 15.1 0.024 14.8 0.1 14.2 12 4 0 12 12 12 11 Immunoglobulin V-set domain EGF_2 PF07974.13 PIK57629.1 - 6.6e-20 71.2 194.5 0.0026 18.1 12.7 10.6 10 0 0 10 10 10 10 EGF-like domain EGF PF00008.27 PIK57629.1 - 2.8e-14 53.1 168.3 0.0037 17.5 9.7 11.9 11 0 0 11 11 11 8 EGF-like domain Ig_6 PF18452.1 PIK57629.1 - 1.8e-12 46.6 11.7 1.9 8.1 0.0 11.4 12 0 0 12 12 12 2 Immunoglobulin domain Izumo-Ig PF16706.5 PIK57629.1 - 1.5e-10 41.0 2.0 4.1 7.5 0.0 10.1 11 1 0 11 11 11 1 Izumo-like Immunoglobulin domain hEGF PF12661.7 PIK57629.1 - 0.19 12.4 153.3 0.29 11.8 6.3 12.7 11 0 0 11 11 11 0 Human growth factor-like EGF Ig_3 PF13927.6 PIK57630.1 - 5.1e-23 81.5 0.0 1.4e-05 25.6 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 PIK57630.1 - 1.3e-19 70.0 0.0 0.0046 17.0 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.25 PIK57630.1 - 6e-18 64.8 0.0 1.2e-06 28.6 0.0 5.0 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK57630.1 - 7.9e-15 55.0 0.6 0.0012 19.0 0.0 4.9 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK57630.1 - 3.3e-12 46.6 0.0 0.053 13.9 0.0 5.1 4 1 0 4 4 4 3 Immunoglobulin domain EGF_2 PF07974.13 PIK57630.1 - 8.1e-11 42.1 103.2 0.0007 19.9 4.8 7.5 7 0 0 7 7 6 5 EGF-like domain RT_RNaseH_2 PF17919.1 PIK57630.1 - 3.3e-09 36.7 0.0 6.8e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Izumo-Ig PF16706.5 PIK57630.1 - 2.5e-06 27.5 0.1 2.1 8.5 0.0 4.6 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain EGF PF00008.27 PIK57630.1 - 3.9e-05 23.8 84.0 0.037 14.3 7.7 7.6 7 0 0 7 7 7 4 EGF-like domain hEGF PF12661.7 PIK57630.1 - 0.0001 22.8 67.6 0.0028 18.2 7.5 8.3 7 1 0 7 7 7 4 Human growth factor-like EGF Ig_6 PF18452.1 PIK57630.1 - 0.00047 19.7 0.1 9.3 5.9 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin domain RLL PF10036.9 PIK57630.1 - 0.31 10.9 1.4 1.7 8.4 0.2 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein EGF PF00008.27 PIK57631.1 - 4.9e-26 90.7 231.4 0.001 19.3 9.2 15.7 15 0 0 15 15 15 12 EGF-like domain EGF_2 PF07974.13 PIK57631.1 - 8.2e-22 77.3 253.5 0.00016 22.0 11.4 14.8 14 1 1 15 15 15 11 EGF-like domain FXa_inhibition PF14670.6 PIK57631.1 - 4.9e-14 52.3 40.7 3.1e-07 30.5 11.3 15.0 6 1 5 11 11 11 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 PIK57631.1 - 3.6e-11 42.8 25.1 1.4e-08 34.5 0.9 15.0 12 4 1 13 13 13 5 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK57631.1 - 6e-10 39.2 21.2 2.4e-06 27.6 8.0 15.7 7 1 7 14 14 14 3 Calcium-binding EGF domain hEGF PF12661.7 PIK57631.1 - 4.4e-08 33.4 229.9 0.0039 17.8 8.5 18.1 18 0 0 18 18 18 11 Human growth factor-like EGF EGF_Tenascin PF18720.1 PIK57631.1 - 0.00018 21.5 9.5 0.00018 21.5 9.5 11.7 12 0 0 12 12 12 4 Tenascin EGF domain I-set PF07679.16 PIK57631.1 - 0.0023 17.9 0.0 0.0046 17.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain cEGF PF12662.7 PIK57632.1 - 4.7e-25 87.2 59.9 5.7e-09 35.7 1.5 6.6 7 0 0 7 7 7 5 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK57632.1 - 4.7e-17 61.9 44.2 2.5e-07 30.8 9.3 6.8 6 1 1 7 7 7 4 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK57632.1 - 2.4e-16 59.7 84.0 4.2e-07 30.1 6.7 6.4 6 2 1 7 7 7 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK57632.1 - 7e-09 35.8 37.4 6.6e-05 23.1 6.5 7.3 7 1 1 8 8 8 4 EGF-like domain EGF_3 PF12947.7 PIK57632.1 - 0.021 15.0 69.8 0.25 11.6 7.8 6.6 4 2 1 5 5 5 0 EGF domain hEGF PF12661.7 PIK57632.1 - 0.046 14.4 18.5 0.066 13.9 4.3 9.9 11 3 2 13 13 13 0 Human growth factor-like EGF Gal-3-0_sulfotr PF06990.11 PIK57633.1 - 1.2e-52 179.2 0.1 1.6e-52 178.7 0.1 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 PIK57633.1 - 0.0088 16.0 0.8 0.017 15.1 0.8 1.7 1 1 0 1 1 1 1 Sulfotransferase family NHL PF01436.21 PIK57634.1 - 0.00023 21.1 0.0 0.059 13.4 0.0 4.0 5 0 0 5 5 5 1 NHL repeat COX5B PF01215.19 PIK57634.1 - 0.053 13.2 0.0 8.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Vb SecA_DEAD PF07517.14 PIK57635.1 - 1.2e-31 110.1 0.1 3.3e-31 108.7 0.1 1.7 1 0 0 1 1 1 1 SecA DEAD-like domain Helicase_C PF00271.31 PIK57635.1 - 1.5e-05 25.3 0.4 0.00012 22.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK57635.1 - 3.5e-05 23.7 0.0 9.7e-05 22.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SecA_PP_bind PF01043.20 PIK57635.1 - 0.0006 20.4 0.0 0.0022 18.6 0.0 2.0 1 0 0 1 1 1 1 SecA preprotein cross-linking domain ResIII PF04851.15 PIK57635.1 - 0.00072 19.6 0.1 0.0043 17.1 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TPR_1 PF00515.28 PIK57635.1 - 0.0059 16.4 0.2 0.044 13.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat ZU5 PF00791.20 PIK57636.1 - 3.7e-12 46.4 0.0 8.7e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain T6SS_TssF PF05947.12 PIK57636.1 - 0.097 11.2 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssF Integrase_H2C2 PF17921.1 PIK57637.1 - 2.4e-16 59.6 0.2 5.6e-16 58.4 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK57637.1 - 9.4e-10 38.4 0.0 1.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK57637.1 - 0.00057 20.1 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK57637.1 - 0.0058 16.8 0.6 0.027 14.7 0.6 2.2 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 PIK57638.1 - 1.7e-14 53.9 0.0 7.9e-14 51.7 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK57638.1 - 6.1e-08 32.4 0.1 1.4e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK57638.1 - 0.0054 16.8 1.6 0.012 15.6 1.6 1.7 1 0 0 1 1 1 1 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK57638.1 - 0.0084 16.1 0.4 0.034 14.2 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK57641.1 - 0.0011 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like PCO_ADO PF07847.12 PIK57642.1 - 0.082 12.3 0.2 0.16 11.4 0.2 1.4 1 0 0 1 1 1 0 PCO_ADO TNF PF00229.18 PIK57643.1 - 1.1e-11 44.8 0.0 2.5e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family NPP1 PF05630.11 PIK57643.1 - 0.083 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Necrosis inducing protein (NPP1) MTHFR_C PF12225.8 PIK57643.1 - 0.11 12.2 4.2 0.084 12.5 0.7 2.2 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal HYR PF02494.16 PIK57644.1 - 4.1e-51 171.2 15.4 2.6e-23 82.1 1.5 3.0 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK57644.1 - 0.0077 16.3 0.1 3.1 8.0 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5011) HYR PF02494.16 PIK57645.1 - 8.2e-111 362.5 32.0 3.8e-26 91.2 2.0 5.1 5 0 0 5 5 5 5 HYR domain DUF5011 PF16403.5 PIK57645.1 - 0.019 15.1 0.1 9.6 6.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) HYR PF02494.16 PIK57646.1 - 1e-68 227.7 11.0 3.6e-23 81.7 1.5 3.0 3 0 0 3 3 3 3 HYR domain DUF5011 PF16403.5 PIK57646.1 - 0.0032 17.6 0.9 18 5.6 0.1 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF5011) PA_decarbox PF05870.11 PIK57646.1 - 0.078 12.6 0.1 41 3.8 0.0 3.0 3 0 0 3 3 3 0 Phenolic acid decarboxylase (PAD) HYR PF02494.16 PIK57647.1 - 1.1e-54 182.6 12.7 2.2e-24 85.6 0.2 3.7 3 0 0 3 3 3 3 HYR domain 7tm_2 PF00002.24 PIK57647.1 - 3e-22 79.1 22.3 1.5e-13 50.6 10.1 2.3 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK57647.1 - 6.1e-11 42.7 3.0 1.6e-10 41.3 3.0 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Lectin_C PF00059.21 PIK57648.1 - 7.6e-14 52.4 0.3 7.6e-14 52.4 0.3 1.9 2 1 0 2 2 2 1 Lectin C-type domain UL45 PF05473.12 PIK57648.1 - 0.04 13.5 2.4 0.13 11.9 0.4 2.5 2 1 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DMAP1 PF05499.12 PIK57649.1 - 6.4e-66 221.3 2.5 6.4e-66 221.3 2.5 2.2 2 1 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.5 PIK57649.1 - 0.00028 21.0 0.3 0.00087 19.4 0.3 1.9 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Med21 PF11221.8 PIK57649.1 - 0.022 15.0 2.1 0.053 13.8 2.1 1.8 1 0 0 1 1 1 0 Subunit 21 of Mediator complex ARHGEF5_35 PF15441.6 PIK57649.1 - 0.41 9.6 6.8 0.65 8.9 6.8 1.2 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 UpxZ PF06603.11 PIK57649.1 - 0.71 10.2 4.7 48 4.3 0.0 3.6 4 0 0 4 4 4 0 UpxZ family of transcription anti-terminator antagonists NACHT_N PF17100.5 PIK57649.1 - 2 8.2 6.4 3.5 7.4 5.2 2.0 1 1 1 2 2 2 0 N-terminal domain of NWD NACHT-NTPase adh_short PF00106.25 PIK57650.1 - 4.2e-29 101.4 0.0 5.6e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK57650.1 - 6.2e-15 55.4 0.1 7.7e-15 55.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK57650.1 - 1.3e-08 35.0 0.1 2.6e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 KR domain DDR_swiveling PF18427.1 PIK57650.1 - 0.024 14.7 0.1 0.045 13.8 0.1 1.4 1 0 0 1 1 1 0 DD-reactivating factor swiveling domain adh_short PF00106.25 PIK57651.1 - 8.6e-22 77.6 0.0 1.3e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK57651.1 - 1e-13 51.4 0.0 1.3e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK57651.1 - 2.5e-06 27.5 0.1 5.7e-06 26.4 0.1 1.5 2 0 0 2 2 2 1 KR domain adh_short PF00106.25 PIK57652.1 - 1.6e-28 99.5 0.0 2.1e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK57652.1 - 9.7e-16 58.0 0.0 1.2e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK57652.1 - 2.2e-08 34.2 0.2 3.7e-08 33.5 0.2 1.3 1 0 0 1 1 1 1 KR domain FIST_C PF10442.9 PIK57652.1 - 0.019 15.0 0.1 0.037 14.0 0.1 1.5 1 0 0 1 1 1 0 FIST C domain Polysacc_synt_2 PF02719.15 PIK57652.1 - 0.092 11.9 0.1 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KinB_sensor PF16767.5 PIK57652.1 - 0.11 12.9 0.1 0.19 12.2 0.1 1.3 1 0 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB ATP_bind_1 PF03029.17 PIK57654.1 - 2.1e-69 234.0 0.1 2.1e-69 234.0 0.1 1.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 PIK57654.1 - 7.7e-07 28.8 0.7 2.3e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 PIK57654.1 - 0.0013 18.3 0.1 0.0027 17.3 0.1 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 PIK57654.1 - 0.024 14.7 0.0 0.069 13.2 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Fe-ADH_2 PF13685.6 PIK57654.1 - 0.14 11.8 0.4 0.27 10.9 0.4 1.4 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase FliJ PF02050.16 PIK57654.1 - 0.25 11.6 7.6 0.82 9.9 5.1 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein ubiquitin PF00240.23 PIK57655.1 - 1.3e-34 117.8 0.4 1.7e-34 117.4 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 PIK57655.1 - 6.4e-32 109.2 11.0 9.8e-32 108.6 11.0 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 PIK57655.1 - 3.5e-17 62.0 0.4 5e-17 61.5 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK57655.1 - 5.1e-06 26.9 0.1 1.9e-05 25.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK57655.1 - 0.0027 17.6 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 PIK57655.1 - 0.0039 17.5 0.0 0.0065 16.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK57655.1 - 0.0044 17.1 0.1 0.0091 16.1 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 PIK57655.1 - 0.022 14.8 0.7 6.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 PIK57655.1 - 0.045 14.3 0.1 0.05 14.2 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Bud13 PF09736.9 PIK57656.1 - 3.1e-46 157.4 11.8 3.1e-46 157.4 11.8 4.1 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex RabGAP-TBC PF00566.18 PIK57657.1 - 2.8e-16 59.8 2.2 4.9e-16 59.0 2.2 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 PIK57657.1 - 3.7e-05 24.2 0.0 0.00023 21.7 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain Type_III_YscX PF09474.10 PIK57657.1 - 0.14 12.4 0.3 0.28 11.5 0.3 1.5 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) Cbl_N PF02262.16 PIK57658.1 - 2.6e-47 159.9 0.3 4.2e-47 159.3 0.3 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.14 PIK57658.1 - 4.4e-46 154.6 0.1 8.3e-46 153.8 0.1 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.14 PIK57658.1 - 8e-39 132.2 3.7 1.7e-38 131.2 3.7 1.6 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.6 PIK57658.1 - 1.1e-10 41.2 9.2 2.8e-10 39.9 9.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 PIK57658.1 - 6.8e-09 35.5 8.6 1.5e-08 34.4 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK57658.1 - 2.6e-07 30.9 7.2 6.1e-07 29.7 7.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK57658.1 - 6.9e-07 29.0 8.4 1.5e-06 27.9 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK57658.1 - 1.9e-06 27.8 4.7 5.6e-06 26.3 4.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK57658.1 - 0.0013 18.6 9.9 0.003 17.5 9.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 PIK57658.1 - 0.0023 17.8 8.8 0.01 15.7 8.8 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK57658.1 - 0.025 14.7 7.4 0.063 13.5 7.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 PIK57658.1 - 0.8 10.0 5.0 2 8.7 5.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 PIK57658.1 - 5.8 6.8 8.9 13 5.7 8.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain AAR2 PF05282.11 PIK57659.1 - 3.1e-112 375.5 0.0 3.5e-112 375.3 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein HYR PF02494.16 PIK57660.1 - 2.3e-112 367.5 106.1 3.8e-18 65.6 2.0 12.2 12 0 0 12 12 12 11 HYR domain EGF PF00008.27 PIK57660.1 - 1.1e-20 73.6 194.3 8.3e-08 32.4 7.3 15.6 17 0 0 17 17 17 9 EGF-like domain EGF_2 PF07974.13 PIK57660.1 - 0.0048 17.2 11.2 0.0048 17.2 11.2 15.6 14 0 0 14 14 14 5 EGF-like domain hEGF PF12661.7 PIK57660.1 - 0.014 16.0 1.9 0.014 16.0 1.9 15.9 16 0 0 16 16 16 0 Human growth factor-like EGF DUF5011 PF16403.5 PIK57660.1 - 0.069 13.3 0.4 2.3 8.4 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) Reeler PF02014.16 PIK57661.1 - 2.3e-07 31.6 0.0 2.8e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Reeler domain FimA PF16970.5 PIK57661.1 - 0.092 12.9 0.1 0.99 9.6 0.0 1.9 1 1 1 2 2 2 0 Type-1 fimbrial protein, A HYR PF02494.16 PIK57662.1 - 5.1e-20 71.6 20.8 1.4e-05 25.3 1.5 4.1 4 0 0 4 4 4 4 HYR domain GCV_T_C PF08669.11 PIK57662.1 - 6.2e-05 22.8 0.2 5.7 6.9 0.0 3.7 4 0 0 4 4 4 3 Glycine cleavage T-protein C-terminal barrel domain Big_7 PF17957.1 PIK57662.1 - 0.0024 18.6 7.7 7.5 7.4 0.0 4.0 3 1 1 4 4 4 3 Bacterial Ig domain GST_C PF00043.25 PIK57662.1 - 0.019 15.2 0.5 43 4.4 0.0 3.8 4 0 0 4 4 4 0 Glutathione S-transferase, C-terminal domain Urocanase_N PF17391.2 PIK57662.1 - 0.048 13.3 0.9 2.9 7.6 0.0 3.4 4 0 0 4 4 4 0 Urocanase N-terminal domain 7TM_GPCR_Srh PF10318.9 PIK57662.1 - 1.2 8.1 7.6 8.2 5.4 0.1 3.4 4 0 0 4 4 4 0 Serpentine type 7TM GPCR chemoreceptor Srh ApbE PF02424.15 PIK57662.1 - 5.6 6.4 5.8 28 4.1 0.2 2.9 3 0 0 3 3 3 0 ApbE family HYR PF02494.16 PIK57663.1 - 6.7e-14 52.0 39.7 1.7e-11 44.3 5.2 4.1 2 2 2 4 4 4 4 HYR domain HYR PF02494.16 PIK57664.1 - 2.3e-41 140.0 71.2 6.3e-11 42.4 5.1 7.4 5 2 2 7 7 7 6 HYR domain GCV_T PF01571.21 PIK57664.1 - 9.9e-05 21.8 0.0 2.8 7.2 0.0 4.0 4 0 0 4 4 4 2 Aminomethyltransferase folate-binding domain FAM194 PF14977.6 PIK57664.1 - 0.0014 18.0 3.8 15 4.8 0.1 4.4 4 0 0 4 4 4 2 FAM194 protein DBR1 PF05011.13 PIK57664.1 - 0.33 11.4 11.0 11 6.4 0.2 3.9 4 0 0 4 4 4 0 Lariat debranching enzyme, C-terminal domain Metallothio_Cad PF07846.11 PIK57664.1 - 1.2 9.3 20.5 9.2 6.5 0.7 5.8 4 0 0 4 4 4 0 Metallothionein family NO_synthase PF02898.15 PIK57664.1 - 1.3 7.9 3.2 9.1 5.2 0.1 2.6 3 0 0 3 3 3 0 Nitric oxide synthase, oxygenase domain HYR PF02494.16 PIK57665.1 - 1.1e-35 121.8 55.8 4.9e-13 49.2 0.1 6.4 4 2 2 6 6 6 6 HYR domain EGF PF00008.27 PIK57665.1 - 4.8e-13 49.1 128.3 2.2e-05 24.6 11.7 10.9 11 2 0 11 11 11 6 EGF-like domain Corona_NS2 PF04753.12 PIK57665.1 - 0.00064 20.3 2.5 1.4 9.5 0.2 3.5 3 0 0 3 3 3 2 Coronavirus non-structural protein NS2 HYR PF02494.16 PIK57666.1 - 1.9e-06 28.1 1.7 0.00032 20.9 0.1 2.9 3 0 0 3 3 3 2 HYR domain FGGY_C PF02782.16 PIK57667.1 - 3.4e-67 226.0 0.2 6.4e-67 225.1 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 PIK57667.1 - 5.5e-48 163.7 1.3 2.6e-39 135.3 0.5 2.3 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Osmo_CC PF08946.10 PIK57667.1 - 0.16 12.3 0.4 0.37 11.1 0.4 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil 7tm_1 PF00001.21 PIK57668.1 - 3.9e-34 118.2 4.2 3.9e-34 118.2 4.2 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK57668.1 - 1.7e-08 34.5 10.4 1.7e-08 34.5 10.4 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK57668.1 - 0.002 17.9 15.9 0.009 15.8 15.9 1.9 1 1 0 1 1 1 1 Olfactory receptor DUF4834 PF16118.5 PIK57668.1 - 0.032 15.2 0.1 0.032 15.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) 7TM_GPCR_Srsx PF10320.9 PIK57668.1 - 0.58 9.5 18.0 5.3 6.3 18.0 2.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Tetraspanin PF00335.20 PIK57670.1 - 2.6e-33 115.7 4.0 3.1e-33 115.4 4.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Methyltransf_25 PF13649.6 PIK57671.1 - 1.1e-10 42.1 0.0 2.3e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 PIK57671.1 - 8.8e-10 38.4 0.1 1.4e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 PIK57671.1 - 3.4e-07 30.2 0.4 1.4e-06 28.2 0.4 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK57671.1 - 3.8e-07 30.7 0.0 9.1e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK57671.1 - 1.2e-06 28.5 0.0 6.6e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 PIK57671.1 - 4.1e-06 26.0 0.0 5.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 PIK57671.1 - 1.1e-05 25.4 0.2 1.8e-05 24.7 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 PIK57671.1 - 1.4e-05 24.5 0.0 2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 PIK57671.1 - 5.3e-05 22.8 0.2 8.4e-05 22.2 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 PIK57671.1 - 0.002 17.9 0.1 0.003 17.3 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 PIK57671.1 - 0.0027 17.5 0.2 0.0048 16.7 0.2 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 PIK57671.1 - 0.027 14.3 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.12 PIK57671.1 - 0.06 14.1 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 PIK57671.1 - 0.064 12.8 0.9 0.11 12.0 0.4 1.7 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase DOT1 PF08123.13 PIK57671.1 - 0.077 12.5 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 PIK57671.1 - 0.16 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Hydrolase_6 PF13344.6 PIK57672.1 - 2.1e-23 82.3 0.0 4.9e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 PIK57672.1 - 1.9e-16 59.9 0.0 3.6e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 PIK57672.1 - 4.2e-07 30.5 0.0 0.0001 22.7 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK57672.1 - 7.9e-05 22.8 0.0 0.0002 21.5 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PAXNEB PF05625.11 PIK57673.1 - 1.1e-84 284.8 0.7 1.4e-84 284.4 0.7 1.0 1 0 0 1 1 1 1 PAXNEB protein PAX PF00292.18 PIK57675.1 - 9.7e-68 225.8 0.3 1.1e-67 225.7 0.3 1.0 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 PIK57675.1 - 0.00015 22.3 0.1 0.072 13.7 0.0 2.1 2 0 0 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 PIK57675.1 - 0.00039 20.1 0.0 0.00062 19.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 PIK57675.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 InsA C-terminal domain HTH_28 PF13518.6 PIK57675.1 - 0.035 14.2 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain 5_nucleotid_C PF02872.18 PIK57676.1 - 1.4e-42 145.6 0.0 2.2e-42 144.9 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Pectate_lyase PF03211.13 PIK57676.1 - 0.15 11.6 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 Pectate lyase Zona_pellucida PF00100.23 PIK57677.1 - 1.4e-37 129.9 3.1 3e-37 128.8 2.6 1.8 2 0 0 2 2 2 1 Zona pellucida-like domain Ammonium_transp PF00909.21 PIK57678.1 - 3.4e-110 368.5 24.8 3.8e-110 368.3 24.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Homeodomain PF00046.29 PIK57679.1 - 2.7e-24 84.8 5.3 7.7e-23 80.1 4.7 2.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 PIK57679.1 - 4.6e-05 23.2 0.2 0.0004 20.2 0.2 2.4 2 0 0 2 2 2 1 Homeobox KN domain Cadherin_3 PF16184.5 PIK57679.1 - 0.017 15.1 0.1 0.032 14.3 0.1 1.4 1 0 0 1 1 1 0 Cadherin-like CDC48_2 PF02933.17 PIK57679.1 - 0.083 12.7 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 DUF1323 PF07037.11 PIK57679.1 - 0.1 13.0 0.1 0.26 11.7 0.0 1.7 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) Ig_3 PF13927.6 PIK57680.1 - 1.5e-30 105.6 0.2 6.3e-12 45.9 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK57680.1 - 8e-25 87.0 0.0 4.6e-08 33.3 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK57680.1 - 1.5e-21 76.3 0.3 2.8e-09 36.9 0.0 4.5 3 2 0 3 3 3 3 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK57680.1 - 2.4e-17 62.8 0.3 3.3e-10 39.9 0.0 3.5 3 1 1 4 4 4 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK57680.1 - 1e-16 60.8 0.0 1.7e-06 28.1 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain C1-set PF07654.15 PIK57680.1 - 1e-07 32.2 0.0 0.012 16.0 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK57680.1 - 4.7e-07 30.0 0.0 0.16 12.3 0.0 3.8 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 PIK57680.1 - 4.5e-05 23.6 0.1 3.8 7.7 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK57680.1 - 0.038 13.5 0.0 0.091 12.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK57680.1 - 0.17 11.9 0.2 22 5.2 0.0 3.7 4 1 0 4 4 4 0 C17orf99 Ig domain TMEM154 PF15102.6 PIK57681.1 - 0.00079 19.3 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family I-set PF07679.16 PIK57681.1 - 0.00095 19.2 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Herpes_glycop PF01528.16 PIK57681.1 - 0.012 14.5 0.2 0.015 14.2 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M EVC2_like PF12297.8 PIK57681.1 - 0.015 14.0 0.2 0.021 13.6 0.2 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Ig_3 PF13927.6 PIK57681.1 - 0.032 14.8 0.4 0.097 13.3 0.4 1.8 1 0 0 1 1 1 0 Immunoglobulin domain SieB PF14163.6 PIK57681.1 - 0.038 13.5 0.4 0.063 12.8 0.4 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B RSN1_TM PF13967.6 PIK57681.1 - 0.053 13.3 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport TMEM132D_C PF15706.5 PIK57681.1 - 0.058 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Pex24p PF06398.11 PIK57681.1 - 0.058 12.4 0.1 0.15 11.0 0.0 1.6 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin SIT PF15330.6 PIK57681.1 - 0.071 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4577 PF15145.6 PIK57681.1 - 0.095 12.7 0.7 0.2 11.7 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) EphA2_TM PF14575.6 PIK57681.1 - 0.11 13.4 0.0 0.29 12.0 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 PIK57681.1 - 0.12 12.3 0.2 0.12 12.3 0.2 1.8 2 0 0 2 2 2 0 Syndecan domain DUF1772 PF08592.11 PIK57681.1 - 0.14 12.5 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) MLANA PF14991.6 PIK57681.1 - 0.18 12.1 1.5 3.7 7.9 0.0 2.9 3 0 0 3 3 3 0 Protein melan-A Sigma_reg_N PF13800.6 PIK57681.1 - 0.4 11.0 2.1 0.3 11.4 0.4 1.6 2 0 0 2 2 1 0 Sigma factor regulator N-terminal DUF4083 PF13314.6 PIK57681.1 - 1.1 9.2 6.7 0.25 11.3 3.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) HSL_N PF06350.12 PIK57682.1 - 3.1e-14 52.7 0.0 3.8e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Abhydrolase_3 PF07859.13 PIK57683.1 - 4.6e-11 43.0 0.0 5.8e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 PIK57683.1 - 0.073 12.6 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family DED PF01335.21 PIK57684.1 - 5.3e-17 61.9 1.2 6.8e-17 61.5 1.2 1.2 1 0 0 1 1 1 1 Death effector domain RRM_1 PF00076.22 PIK57686.1 - 1.1e-08 34.7 0.1 2.2e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 PIK57686.1 - 3.9e-07 29.9 0.1 8.5e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 RL domain Nup35_RRM_2 PF14605.6 PIK57686.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-C2H2_2 PF12756.7 PIK57686.1 - 0.016 15.5 0.3 0.016 15.5 0.3 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF3449 PF11931.8 PIK57686.1 - 0.041 13.7 0.7 0.041 13.7 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3449) PAP_assoc PF03828.19 PIK57686.1 - 0.045 14.0 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Cid1 family poly A polymerase zf-met PF12874.7 PIK57686.1 - 0.71 10.3 5.2 1.8 9.1 3.1 2.8 3 1 0 3 3 3 0 Zinc-finger of C2H2 type MRNIP PF15749.5 PIK57686.1 - 2.8 8.7 6.9 0.89 10.3 0.2 2.5 2 1 0 2 2 2 0 MRN-interacting protein UQ_con PF00179.26 PIK57687.1 - 6.6e-23 80.9 0.0 4.4e-22 78.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme CENP-B_dimeris PF09026.10 PIK57687.1 - 0.0038 17.6 6.5 0.0038 17.6 6.5 1.9 2 0 0 2 2 2 1 Centromere protein B dimerisation domain GCIP PF13324.6 PIK57687.1 - 0.0071 16.0 0.1 0.0084 15.7 0.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Claudin_2 PF13903.6 PIK57687.1 - 1.3 8.7 17.1 2.4 7.9 17.1 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction NOA36 PF06524.12 PIK57687.1 - 1.8 7.8 11.4 2.7 7.2 11.4 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 PIK57687.1 - 4.6 5.9 23.7 5.7 5.6 23.7 1.1 1 0 0 1 1 1 0 Presenilin RRM_1 PF00076.22 PIK57689.1 - 4e-09 36.2 0.1 8e-09 35.2 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAP_assoc PF03828.19 PIK57689.1 - 1.7e-08 34.6 0.0 3.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase RL PF17797.1 PIK57689.1 - 2e-07 30.8 0.1 4.6e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 RL domain NTP_transf_2 PF01909.23 PIK57689.1 - 1.6e-05 25.1 0.0 9.5e-05 22.6 0.0 2.3 2 1 0 2 2 2 1 Nucleotidyltransferase domain Nup35_RRM_2 PF14605.6 PIK57689.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PAP_central PF04928.17 PIK57689.1 - 0.031 13.3 0.0 0.065 12.2 0.0 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain RRM_occluded PF16842.5 PIK57689.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif UPF0193 PF05250.11 PIK57690.1 - 3.3e-60 203.6 8.2 3.7e-60 203.4 8.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) DUF3585 PF12130.8 PIK57691.1 - 2e-37 128.3 30.2 2.4e-37 128.1 30.2 1.1 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain DUF4936 PF16290.5 PIK57691.1 - 0.14 12.8 2.9 0.18 12.5 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4936) Thg1C PF14413.6 PIK57691.1 - 0.22 11.7 5.9 0.32 11.2 5.4 1.7 1 1 0 1 1 1 0 Thg1 C terminal domain Nudc_N PF14050.6 PIK57693.1 - 4.7e-21 74.5 0.2 8.6e-21 73.7 0.2 1.4 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 PIK57693.1 - 6.7e-07 30.2 0.9 1.8e-06 28.9 0.9 1.7 1 0 0 1 1 1 1 CS domain YqeY PF09424.10 PIK57693.1 - 0.32 11.1 7.1 0.75 9.9 0.4 2.5 2 1 1 3 3 3 0 Yqey-like protein Phi_1 PF04674.12 PIK57693.1 - 0.39 10.0 7.6 0.23 10.7 0.2 2.1 1 1 0 2 2 2 0 Phosphate-induced protein 1 conserved region DUF5398 PF17376.2 PIK57693.1 - 3.9 8.2 9.7 0.27 11.9 0.5 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5398) CKAP2_C PF15297.6 PIK57693.1 - 8.6 5.3 14.7 0.27 10.3 5.4 2.0 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus Pyr_redox_3 PF13738.6 PIK57695.1 - 3.3e-15 56.1 0.0 1.1e-10 41.3 0.0 2.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK57695.1 - 2.2e-05 23.8 0.0 2.6e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 PIK57695.1 - 0.0016 16.9 0.1 0.0051 15.3 0.0 1.7 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 PIK57695.1 - 0.0043 16.3 0.0 0.011 15.0 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 PIK57695.1 - 0.018 14.4 0.0 0.084 12.1 0.0 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase DAO PF01266.24 PIK57695.1 - 0.022 14.4 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK57695.1 - 0.11 12.5 0.0 0.33 10.9 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding p450 PF00067.22 PIK57696.1 - 6e-61 206.6 0.0 6.8e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK57697.1 - 4.9e-33 114.6 0.0 5.7e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GIY-YIG PF01541.24 PIK57698.1 - 2.1e-05 24.7 0.1 5.5e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 GIY-YIG catalytic domain Ribosomal_S8 PF00410.19 PIK57699.1 - 4.9e-23 81.5 0.0 5.6e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Tom22 PF04281.13 PIK57700.1 - 5.7e-13 48.8 0.3 6.8e-13 48.6 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Chibby PF14645.6 PIK57701.1 - 4.1e-38 130.4 4.5 4.6e-38 130.2 4.5 1.0 1 0 0 1 1 1 1 Chibby family YabA PF06156.13 PIK57701.1 - 0.32 11.7 3.4 0.38 11.4 2.3 1.6 2 0 0 2 2 2 0 Initiation control protein YabA Thyroglobulin_1 PF00086.18 PIK57702.1 - 1.9e-06 27.4 0.6 3.1e-06 26.7 0.6 1.4 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Thioredoxin PF00085.20 PIK57703.1 - 5.7e-15 55.2 0.2 2.9e-12 46.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 PIK57703.1 - 0.13 12.6 0.1 3.2 8.1 0.0 3.0 2 1 0 2 2 2 0 Thioredoxin-like MFS_1 PF07690.16 PIK57704.1 - 0.0032 16.4 1.1 0.004 16.1 1.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK57705.1 - 4.5e-20 71.6 25.6 1.9e-15 56.4 20.5 2.8 1 1 1 2 2 2 2 MFS/sugar transport protein EF_assoc_2 PF08356.12 PIK57707.1 - 6e-36 122.3 0.0 1.1e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 PIK57707.1 - 6.9e-24 84.3 0.0 7.8e-20 71.1 0.0 2.3 2 0 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 PIK57707.1 - 4.3e-12 45.5 0.4 2e-11 43.3 0.1 2.3 2 1 0 2 2 2 1 EF hand associated Roc PF08477.13 PIK57707.1 - 1.7e-10 41.2 0.0 1.9e-09 37.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_6 PF13405.6 PIK57707.1 - 1.7e-07 30.6 0.0 0.0016 18.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK57707.1 - 2.4e-07 29.8 0.1 0.0031 16.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK57707.1 - 1.7e-06 28.4 0.0 0.014 15.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair SRPRB PF09439.10 PIK57707.1 - 6.1e-06 25.8 0.1 2.3e-05 23.9 0.0 2.0 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit EF-hand_5 PF13202.6 PIK57707.1 - 4.5e-05 22.8 0.3 0.0014 18.0 0.0 2.5 2 0 0 2 2 2 1 EF hand Arf PF00025.21 PIK57707.1 - 0.00071 19.1 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 PIK57707.1 - 0.00073 19.5 0.4 0.6 10.0 0.0 3.2 5 0 0 5 5 3 2 RsgA GTPase MMR_HSR1 PF01926.23 PIK57707.1 - 0.0031 17.6 0.0 0.021 14.9 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase SPARC_Ca_bdg PF10591.9 PIK57707.1 - 0.0032 17.8 0.0 4 7.8 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region AAA_16 PF13191.6 PIK57707.1 - 0.06 13.7 0.1 0.15 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 PIK57707.1 - 0.093 12.5 0.0 5 6.9 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 PIK57707.1 - 0.11 12.3 0.0 1.8 8.3 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 PIK57707.1 - 0.22 11.2 0.0 0.44 10.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ANAPC4_WD40 PF12894.7 PIK57708.1 - 1.3e-08 35.0 0.0 0.00016 21.9 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK57708.1 - 2.8e-06 27.9 0.0 0.66 10.9 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_2 PF13360.6 PIK57708.1 - 0.11 12.1 0.0 4.5 6.8 0.0 2.7 2 1 0 2 2 2 0 PQQ-like domain PQQ PF01011.21 PIK57708.1 - 0.11 12.5 0.3 8.5 6.5 0.0 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat MFS_1 PF07690.16 PIK57710.1 - 2e-05 23.7 2.1 2.9e-05 23.2 2.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Nucleos_tra2_C PF07662.13 PIK57711.1 - 3e-24 86.0 1.4 5.6e-24 85.2 0.2 1.8 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Gate PF07670.14 PIK57711.1 - 0.037 14.3 0.4 0.037 14.3 0.4 1.9 2 0 0 2 2 2 0 Nucleoside recognition Lectin_C PF00059.21 PIK57712.1 - 7.1e-13 49.2 1.4 7.9e-13 49.1 1.4 1.0 1 0 0 1 1 1 1 Lectin C-type domain EGF_CA PF07645.15 PIK57713.1 - 1.6e-44 149.8 110.5 1.6e-09 37.8 10.5 7.1 7 0 0 7 7 7 6 Calcium-binding EGF domain cEGF PF12662.7 PIK57713.1 - 1.1e-23 82.8 69.6 3.7e-06 26.8 2.3 7.2 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK57713.1 - 2.3e-11 43.7 108.9 0.0013 18.9 8.6 7.3 7 1 0 7 7 7 5 EGF domain FXa_inhibition PF14670.6 PIK57713.1 - 1.5e-09 37.9 99.3 0.004 17.4 7.0 7.0 6 1 1 7 7 7 6 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK57713.1 - 1.6e-09 38.0 71.9 0.0045 17.6 1.7 9.3 10 1 1 11 11 11 6 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK57713.1 - 6.6e-06 26.1 63.6 0.22 11.6 5.3 6.8 6 0 0 6 6 6 6 MSP1 EGF domain 1 EGF PF00008.27 PIK57713.1 - 7.8e-06 26.1 87.3 0.011 16.0 4.4 8.5 8 2 0 8 8 8 5 EGF-like domain DUF3297 PF11730.8 PIK57713.1 - 0.0018 18.1 7.7 3 7.8 0.1 4.3 4 0 0 4 4 4 1 Protein of unknown function (DUF3297) Fibrinogen_C PF00147.18 PIK57714.1 - 1.9e-35 122.7 4.1 2.6e-35 122.3 4.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF3438 PF11920.8 PIK57714.1 - 0.22 10.7 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Fibrinogen_C PF00147.18 PIK57715.1 - 1.3e-52 178.8 5.7 1.6e-52 178.5 5.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Glyco_transf_22 PF03901.17 PIK57716.1 - 3.4e-106 356.0 29.0 4e-106 355.7 29.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family RPN2_C PF18004.1 PIK57717.1 - 2.1e-32 112.3 25.8 2.1e-32 112.3 25.8 3.0 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 PIK57717.1 - 3.4e-27 93.5 11.3 0.00027 21.2 0.0 6.8 6 0 0 6 6 6 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 PIK57717.1 - 1.7e-18 66.8 0.2 1.9e-12 47.4 0.0 4.4 2 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 PIK57717.1 - 0.00056 19.9 0.2 3.8 8.0 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat XRCC4 PF06632.12 PIK57717.1 - 0.0083 15.0 0.0 0.0083 15.0 0.0 3.0 3 0 0 3 3 3 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 HEAT_EZ PF13513.6 PIK57717.1 - 0.14 12.7 0.3 35 5.0 0.0 3.8 3 1 2 5 5 5 0 HEAT-like repeat SID-1_RNA_chan PF13965.6 PIK57717.1 - 2.3 6.5 5.2 0.55 8.6 1.3 1.9 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DDHD PF02862.17 PIK57717.1 - 3.4 7.8 11.3 44 4.1 0.0 2.4 2 0 0 2 2 2 0 DDHD domain SPATIAL PF15256.6 PIK57717.1 - 4.4 7.6 16.3 0.066 13.6 8.0 2.2 2 1 0 2 2 2 0 SPATIAL FGGY_N PF00370.21 PIK57718.1 - 3.8e-32 111.8 0.8 2.8e-30 105.7 0.8 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 PIK57718.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain SpmSyn_N PF17950.1 PIK57719.1 - 0.083 13.1 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Glyco_transf_8 PF01501.20 PIK57720.1 - 4.9e-15 55.8 0.0 1.5e-08 34.5 0.0 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 PIK57720.1 - 7.9e-05 22.1 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Fam20C PF06702.12 PIK57720.1 - 0.094 12.5 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Golgi casein kinase, C-terminal, Fam20 Folate_carrier PF01770.18 PIK57721.1 - 5e-138 460.3 23.5 5.3e-137 456.9 23.5 1.9 1 1 0 1 1 1 1 Reduced folate carrier Spc7 PF08317.11 PIK57722.1 - 0.002 17.1 19.9 0.002 17.1 19.9 7.5 2 1 7 9 9 9 5 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 PIK57722.1 - 0.0026 18.0 8.4 0.0026 18.0 8.4 12.4 2 2 10 12 12 12 6 TATA element modulatory factor 1 TATA binding GRIP PF01465.20 PIK57723.1 - 3e-16 59.1 0.7 2.1e-15 56.3 0.4 2.7 2 0 0 2 2 2 1 GRIP domain Rab_bind PF16704.5 PIK57723.1 - 5.2e-10 39.2 7.0 5.2e-10 39.2 7.0 6.0 7 2 1 8 8 8 1 Rab binding domain SlyX PF04102.12 PIK57723.1 - 0.0014 19.2 5.7 0.0014 19.2 5.7 10.5 4 3 6 11 11 11 2 SlyX Bap31_Bap29_C PF18035.1 PIK57723.1 - 0.01 15.8 5.4 0.01 15.8 5.4 10.7 8 3 0 8 8 8 0 Bap31/Bap29 cytoplasmic coiled-coil domain ERM PF00769.19 PIK57723.1 - 4.9 6.9 152.2 0.015 15.1 49.3 5.4 1 1 4 5 5 5 0 Ezrin/radixin/moesin family TPR_1 PF00515.28 PIK57724.1 - 1.8e-12 46.5 0.4 3.7e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK57724.1 - 5.1e-11 41.8 0.4 9.2e-05 22.3 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK57724.1 - 1.8e-10 40.3 0.2 2.7e-09 36.5 0.1 2.3 1 1 1 2 2 2 1 TPR repeat TPR_16 PF13432.6 PIK57724.1 - 1.1e-06 29.2 0.3 2.1e-06 28.3 0.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK57724.1 - 2.2e-06 27.7 0.0 1.1e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK57724.1 - 1.9e-05 24.9 0.5 0.00017 21.8 0.4 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57724.1 - 3.6e-05 23.6 0.1 0.033 14.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat S1 PF00575.23 PIK57724.1 - 8.7e-05 22.8 3.9 0.11 12.9 0.1 3.1 4 0 0 4 4 3 2 S1 RNA binding domain TPR_10 PF13374.6 PIK57724.1 - 0.00015 21.5 0.2 0.018 14.9 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK57724.1 - 0.00025 21.5 0.1 0.00047 20.6 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK57724.1 - 0.00036 21.1 0.2 0.049 14.5 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK57724.1 - 0.00037 20.7 0.5 0.0039 17.5 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK57724.1 - 0.0028 16.7 0.0 0.0028 16.7 0.0 1.4 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 MAS20 PF02064.15 PIK57724.1 - 0.0044 17.1 0.5 0.78 9.8 0.1 2.8 2 1 1 3 3 3 1 MAS20 protein import receptor TPR_7 PF13176.6 PIK57724.1 - 0.013 15.5 0.1 3.9 7.7 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK57724.1 - 0.045 14.4 0.8 12 6.8 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK57724.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat MAPEG PF01124.18 PIK57727.1 - 6.5e-13 48.7 1.8 1.1e-12 48.0 1.8 1.3 1 0 0 1 1 1 1 MAPEG family TTKRSYEDQ PF10212.9 PIK57727.1 - 0.12 11.4 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Claudin_2 PF13903.6 PIK57727.1 - 1.1 8.9 7.3 0.14 11.9 2.9 1.8 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Rib_hydrolayse PF02267.17 PIK57728.1 - 7.8e-50 169.5 0.0 8.9e-50 169.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase DUF3775 PF12616.8 PIK57728.1 - 0.24 11.5 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) z-alpha PF02295.17 PIK57729.1 - 0.87 9.7 7.9 0.12 12.4 2.2 2.6 3 0 0 3 3 3 0 Adenosine deaminase z-alpha domain GrpE PF01025.19 PIK57729.1 - 9.4 5.9 23.2 0.26 10.9 8.6 3.0 2 1 1 3 3 3 0 GrpE Dermcidin PF15291.6 PIK57730.1 - 0.0066 17.0 13.7 0.19 12.3 2.2 3.2 2 1 0 2 2 2 2 Dermcidin, antibiotic peptide XPG_N PF00752.17 PIK57731.1 - 1.6e-28 99.1 0.0 4.1e-28 97.8 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 PIK57731.1 - 1.3e-06 28.6 0.1 1.3e-06 28.6 0.1 3.1 3 1 0 3 3 3 1 XPG I-region Trimer_CC PF08954.11 PIK57732.1 - 0.018 14.6 0.7 0.018 14.6 0.7 4.0 4 0 0 4 4 4 0 Trimerisation motif FUSC PF04632.12 PIK57732.1 - 0.089 11.3 1.0 0.17 10.4 0.2 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family NYD-SP28_assoc PF14775.6 PIK57732.1 - 5.2 7.3 10.5 14 5.9 0.9 4.2 3 1 0 3 3 3 0 Sperm tail C-terminal domain SOAR PF16533.5 PIK57732.1 - 6.8 6.7 13.8 0.088 12.8 0.3 4.4 3 1 0 3 3 3 0 STIM1 Orai1-activating region HYR PF02494.16 PIK57734.1 - 3.1e-12 46.6 0.5 3.1e-12 46.6 0.5 2.4 3 0 0 3 3 3 1 HYR domain Ldl_recept_a PF00057.18 PIK57734.1 - 2.4e-07 30.8 14.9 0.00017 21.7 3.1 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 PIK57736.1 - 0.018 15.3 27.0 0.49 10.7 6.2 3.4 3 0 0 3 3 3 0 Low-density lipoprotein receptor domain class A Ependymin PF00811.18 PIK57737.1 - 7.3e-16 58.6 0.0 9.5e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Ependymin DctM PF06808.12 PIK57737.1 - 0.16 10.7 0.5 0.2 10.4 0.5 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component Glyco_hydro_31 PF01055.26 PIK57738.1 - 2.7e-119 399.2 0.9 3.5e-119 398.9 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK57738.1 - 9e-22 77.5 0.4 2e-21 76.4 0.4 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 PIK57738.1 - 2.2e-07 31.1 5.0 4.9e-06 26.8 0.1 3.7 4 0 0 4 4 4 1 Galactose mutarotase-like Trefoil PF00088.18 PIK57738.1 - 9.8e-06 25.4 6.7 2.6e-05 24.0 6.7 1.7 1 0 0 1 1 1 1 Trefoil (P-type) domain Collagen PF01391.18 PIK57739.1 - 6.6e-17 61.0 47.0 1.5e-09 37.5 20.8 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) JAB PF01398.21 PIK57741.1 - 5.6e-34 116.6 0.1 9.7e-34 115.9 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease BRCC36_C PF18110.1 PIK57741.1 - 1e-26 92.9 0.7 1.9e-26 92.0 0.7 1.5 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain Prok-JAB PF14464.6 PIK57741.1 - 9.2e-09 35.1 0.1 1.5e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 PIK57741.1 - 0.019 15.0 0.0 0.097 12.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) CEP63 PF17045.5 PIK57743.1 - 6.8e-33 114.7 43.5 6.8e-33 114.7 43.5 3.9 1 1 0 2 2 2 1 Centrosomal protein of 63 kDa Tup_N PF08581.10 PIK57743.1 - 0.001 19.3 10.8 0.001 19.3 10.8 6.5 4 2 2 6 6 6 2 Tup N-terminal HALZ PF02183.18 PIK57743.1 - 0.0016 18.6 5.6 0.0016 18.6 5.6 4.2 4 0 0 4 4 4 1 Homeobox associated leucine zipper YabA PF06156.13 PIK57743.1 - 0.0035 18.0 3.4 0.0035 18.0 3.4 6.8 2 2 4 7 7 7 1 Initiation control protein YabA Glutaredoxin2_C PF04399.13 PIK57743.1 - 4.7 7.1 17.1 0.26 11.1 0.4 4.3 3 2 1 5 5 5 0 Glutaredoxin 2, C terminal domain RVT_1 PF00078.27 PIK57744.1 - 1.5e-08 34.4 0.0 2.8e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med11 PF10280.9 PIK57744.1 - 0.16 12.4 4.5 0.73 10.3 4.5 1.9 1 1 0 1 1 1 0 Mediator complex protein Integrase_H2C2 PF17921.1 PIK57745.1 - 1.3e-23 82.8 0.1 2.6e-23 81.9 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK57745.1 - 8.5e-18 64.6 0.2 1.7e-17 63.6 0.2 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK57745.1 - 8.8e-07 28.9 0.0 2.1e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK57745.1 - 0.00028 21.0 0.0 0.0007 19.8 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Chromo PF00385.24 PIK57746.1 - 0.0091 15.9 0.1 0.022 14.7 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ATP-grasp_2 PF08442.10 PIK57747.1 - 3.2e-75 252.1 0.9 5.5e-75 251.4 0.9 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 PIK57747.1 - 4.5e-26 91.5 0.9 8.2e-26 90.7 0.9 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 PIK57747.1 - 2.5e-13 50.0 0.1 4.3e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 PIK57747.1 - 0.0012 18.7 0.2 0.0026 17.5 0.2 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF2922 PF11148.8 PIK57747.1 - 0.02 14.6 0.6 0.33 10.7 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2922) PuR_N PF09182.10 PIK57747.1 - 0.15 12.0 0.1 0.36 10.8 0.1 1.6 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal S-methyl_trans PF02574.16 PIK57748.1 - 8.7e-59 199.5 0.0 9.9e-59 199.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Prefoldin PF02996.17 PIK57748.1 - 0.12 12.3 1.0 0.23 11.4 1.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit S-methyl_trans PF02574.16 PIK57749.1 - 1.6e-63 215.0 0.0 1.8e-63 214.8 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase RGS-like PF09128.11 PIK57749.1 - 0.096 12.4 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Pkinase PF00069.25 PIK57750.1 - 1.4e-69 234.4 0.0 2e-69 233.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57750.1 - 7.1e-44 150.0 0.3 1.3e-43 149.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 PIK57750.1 - 2.6e-22 78.9 0.0 7.5e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 PIK57750.1 - 1.1e-07 31.5 0.1 0.00024 20.5 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 PIK57750.1 - 1e-06 27.8 0.2 2.8e-06 26.4 0.1 1.9 1 1 1 2 2 2 1 Fungal protein kinase APH PF01636.23 PIK57750.1 - 0.029 14.3 0.0 0.68 9.8 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.12 PIK57750.1 - 0.037 13.7 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain DUF5558 PF17713.1 PIK57750.1 - 2.1 8.7 5.9 0.78 10.1 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5558) DEAD PF00270.29 PIK57751.1 - 6.8e-52 175.8 0.0 1.1e-51 175.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK57751.1 - 1.9e-24 86.1 0.0 4.2e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK57751.1 - 3.6e-05 23.8 0.0 5.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HEM4 PF02602.15 PIK57751.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Ras PF00071.22 PIK57752.1 - 2.1e-58 196.5 0.3 2.7e-58 196.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57752.1 - 5.4e-36 123.4 0.2 8.6e-36 122.8 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57752.1 - 3.9e-15 55.7 0.1 5e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK57752.1 - 3.1e-06 26.9 0.1 1.8e-05 24.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK57752.1 - 9.3e-06 25.2 0.1 1.4e-05 24.6 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK57752.1 - 5.6e-05 23.2 0.0 9.4e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK57752.1 - 0.00011 21.8 0.2 0.0024 17.4 0.2 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 PIK57752.1 - 0.00026 20.4 0.2 0.00032 20.1 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 PIK57752.1 - 0.0003 20.7 0.1 0.15 11.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase DUF1854 PF08909.11 PIK57752.1 - 0.092 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) Motile_Sperm PF00635.26 PIK57753.1 - 1e-15 57.5 0.0 1.6e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Pyr_redox_2 PF07992.14 PIK57754.1 - 1.5e-46 159.0 2.8 1.9e-46 158.6 2.8 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK57754.1 - 6.9e-14 52.2 1.4 9.6e-11 42.1 0.2 3.0 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK57754.1 - 1.1e-09 38.0 1.7 1.5e-07 31.0 0.5 2.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK57754.1 - 1.2e-07 31.8 2.6 0.034 14.1 0.0 4.3 3 1 1 4 4 4 2 FAD-NAD(P)-binding DAO PF01266.24 PIK57754.1 - 1.6e-07 31.2 7.1 0.023 14.3 0.1 4.1 3 1 1 4 4 4 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 PIK57754.1 - 6e-07 28.9 0.4 0.0022 17.2 0.1 2.6 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 PIK57754.1 - 7.8e-06 25.2 0.9 0.27 10.2 0.0 4.0 3 1 1 4 4 4 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 PIK57754.1 - 7.1e-05 23.2 4.5 0.0059 17.0 0.0 2.7 2 1 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 PIK57754.1 - 0.00028 20.3 0.0 0.058 12.7 0.0 2.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 PIK57754.1 - 0.0008 19.7 0.7 1.9 8.8 0.1 3.1 3 0 0 3 3 3 2 TrkA-N domain GIDA PF01134.22 PIK57754.1 - 0.004 16.3 13.1 0.17 10.9 0.0 4.2 4 1 1 5 5 5 2 Glucose inhibited division protein A Shikimate_DH PF01488.20 PIK57754.1 - 0.0052 16.8 1.5 0.59 10.2 0.0 3.4 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase DUF1188 PF06690.11 PIK57754.1 - 0.0094 15.5 0.1 0.087 12.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) ThiF PF00899.21 PIK57754.1 - 0.013 14.8 1.3 0.17 11.2 0.0 2.5 3 0 0 3 3 3 0 ThiF family NAD_binding_8 PF13450.6 PIK57754.1 - 0.014 15.6 0.7 1.8 8.9 0.1 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 PIK57754.1 - 0.017 14.0 6.8 2.5 6.8 0.1 3.9 2 2 2 4 4 4 0 Tryptophan halogenase Peroxidase_ext PF11895.8 PIK57754.1 - 0.17 11.9 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Fungal peroxidase extension region Amino_oxidase PF01593.24 PIK57754.1 - 0.19 11.0 0.1 5.6 6.1 0.1 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase KOW PF00467.29 PIK57754.1 - 1.3 9.1 6.0 7.3 6.7 0.2 3.0 3 0 0 3 3 3 0 KOW motif FAM70 PF14967.6 PIK57755.1 - 0.017 14.6 12.3 0.012 15.0 9.4 1.9 1 1 1 2 2 2 0 FAM70 protein Dzip-like_N PF13815.6 PIK57756.1 - 6.2e-32 110.0 7.5 1e-31 109.3 7.5 1.3 1 0 0 1 1 1 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal TMEM214 PF10151.9 PIK57756.1 - 0.012 14.1 3.7 0.015 13.8 3.7 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator LepB_GAP_C PF18227.1 PIK57756.1 - 0.059 13.9 0.3 0.11 13.1 0.3 1.5 1 0 0 1 1 1 0 LepB GAP domain C-terminal subdomain Phycobilisome PF00502.19 PIK57756.1 - 0.082 12.8 0.4 0.14 12.0 0.4 1.4 1 0 0 1 1 1 0 Phycobilisome protein SYCP2_SLD PF18584.1 PIK57756.1 - 0.14 12.4 2.7 0.21 11.8 2.7 1.3 1 0 0 1 1 1 0 Synaptonemal complex 2 Spt16M-like domain DUF1713 PF08213.11 PIK57756.1 - 0.38 10.7 6.7 0.11 12.4 1.1 2.3 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1713) AIP3 PF03915.13 PIK57757.1 - 0.073 12.2 32.2 0.09 11.9 32.2 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 Apolipoprotein PF01442.18 PIK57757.1 - 0.24 11.3 43.5 0.28 11.0 16.7 2.8 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 PIK57757.1 - 0.47 10.5 29.1 98 3.0 22.5 3.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) COG2 PF06148.11 PIK57757.1 - 2.7 8.1 29.8 1.4 9.0 7.6 3.2 2 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 APG17 PF04108.12 PIK57757.1 - 4.4 6.3 31.6 66 2.4 31.6 2.0 1 1 0 1 1 1 0 Autophagy protein Apg17 DNA_pol_phi PF04931.13 PIK57758.1 - 2.9 5.9 11.6 5 5.1 11.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF4407 PF14362.6 PIK57758.1 - 3.9 6.7 5.1 6.2 6.1 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UCH PF00443.29 PIK57759.1 - 1.2e-22 80.7 0.0 1.5e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK57759.1 - 1e-07 31.9 0.2 1.5e-07 31.3 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 PIK57760.1 - 1.6e-12 47.5 0.3 8.4e-08 32.0 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK57760.1 - 0.035 13.7 4.9 0.81 9.2 4.9 2.2 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 PIK57760.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Importin_rep_4 PF18808.1 PIK57761.1 - 3.3e-29 101.0 0.3 3.3e-29 101.0 0.3 3.8 6 0 0 6 6 4 1 Importin repeat HEAT PF02985.22 PIK57761.1 - 8.8e-15 53.6 4.4 8.9e-05 22.4 0.0 7.2 7 0 0 7 7 6 3 HEAT repeat HEAT_EZ PF13513.6 PIK57761.1 - 5.1e-14 52.4 1.1 3.8e-10 40.1 0.1 6.2 7 0 0 7 7 6 1 HEAT-like repeat HEAT_2 PF13646.6 PIK57761.1 - 6.9e-14 52.0 3.1 6.9e-09 36.0 0.1 6.5 7 2 1 8 8 8 2 HEAT repeats Importin_rep_6 PF18829.1 PIK57761.1 - 3.1e-12 46.6 3.6 4.9e-12 45.9 0.9 2.8 2 0 0 2 2 2 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 PIK57761.1 - 1.7e-11 44.6 1.6 7.1e-07 29.7 0.0 6.1 4 1 3 7 7 7 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK57761.1 - 7.2e-09 35.9 0.1 8.9e-05 22.6 0.0 4.2 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK57761.1 - 2.7e-05 22.9 0.0 0.002 16.8 0.0 2.9 2 1 0 2 2 2 1 Adaptin N terminal region DUF3385 PF11865.8 PIK57761.1 - 0.00054 19.9 8.4 1.8 8.4 0.0 7.2 5 2 3 9 9 9 1 Domain of unknown function (DUF3385) HEAT_PBS PF03130.16 PIK57761.1 - 0.00055 20.4 0.4 9 7.3 0.0 5.4 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat Arm PF00514.23 PIK57761.1 - 0.0006 19.8 0.4 0.5 10.5 0.0 4.0 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 PIK57761.1 - 0.0025 17.7 0.1 0.78 9.7 0.0 4.2 4 0 0 4 4 4 1 Importin-beta N-terminal domain UME PF08064.13 PIK57761.1 - 0.0027 17.6 0.5 3.4 7.6 0.0 4.8 4 0 0 4 4 4 1 UME (NUC010) domain RIX1 PF08167.12 PIK57761.1 - 0.015 15.0 0.1 14 5.3 0.0 4.2 7 0 0 7 7 7 0 rRNA processing/ribosome biogenesis Omptin PF01278.20 PIK57762.1 - 0.054 12.5 0.1 0.062 12.3 0.1 1.2 1 0 0 1 1 1 0 Omptin family DUF3761 PF12587.8 PIK57762.1 - 0.057 13.9 1.0 0.077 13.4 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) tRNA-synt_1e PF01406.19 PIK57763.1 - 4.7e-101 338.1 0.0 7.1e-101 337.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 PIK57763.1 - 4.1e-06 25.8 0.4 0.0067 15.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 PIK57763.1 - 0.0074 16.7 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 DALR domain tRNA-synt_1 PF00133.22 PIK57763.1 - 0.016 13.5 0.0 0.034 12.4 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 PIK57763.1 - 0.022 13.7 0.1 0.11 11.4 0.0 2.0 2 1 0 2 2 2 0 tRNA synthetases class I (K) Augurin PF15187.6 PIK57763.1 - 0.15 12.2 0.5 0.5 10.6 0.1 2.0 2 0 0 2 2 2 0 Oesophageal cancer-related gene 4 MIT PF04212.18 PIK57764.1 - 3.2e-05 23.9 0.9 7.8e-05 22.7 0.9 1.7 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain Neuropep_like PF15161.6 PIK57764.1 - 0.0025 17.5 0.2 1.4 8.7 0.3 2.4 2 0 0 2 2 2 2 Neuropeptide-like Apolipoprotein PF01442.18 PIK57764.1 - 0.0051 16.7 0.6 0.0071 16.2 0.6 1.3 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain TPR_1 PF00515.28 PIK57764.1 - 0.0074 16.1 0.8 0.0074 16.1 0.8 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF1640 PF07798.11 PIK57764.1 - 0.011 15.7 0.3 0.017 15.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) TPR_6 PF13174.6 PIK57764.1 - 0.013 16.1 1.3 0.088 13.5 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK57764.1 - 0.022 14.8 0.2 0.082 13.0 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK57764.1 - 0.028 14.5 0.3 0.028 14.5 0.3 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK57764.1 - 0.03 14.5 2.2 0.053 13.8 0.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Aida_N PF08910.10 PIK57764.1 - 0.058 13.8 0.2 2.3 8.6 0.3 2.3 1 1 1 2 2 2 0 Aida N-terminus TPR_12 PF13424.6 PIK57764.1 - 0.082 13.2 1.8 0.15 12.4 0.3 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat PspB PF06667.12 PIK57764.1 - 4.7 7.4 5.5 2.9 8.0 1.5 2.7 2 1 0 2 2 2 0 Phage shock protein B Senescence PF06911.12 PIK57765.1 - 6.8e-34 117.8 0.3 1.1e-33 117.1 0.3 1.3 1 0 0 1 1 1 1 Senescence-associated protein Inp1 PF12634.7 PIK57765.1 - 0.0014 18.6 0.0 0.0051 16.8 0.0 1.8 1 1 1 2 2 2 1 Inheritance of peroxisomes protein 1 SH3_9 PF14604.6 PIK57766.1 - 1e-16 60.5 1.0 2.9e-11 43.1 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK57766.1 - 6.1e-13 48.2 0.6 1.8e-11 43.5 0.1 2.4 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 PIK57766.1 - 1.3e-12 47.1 0.3 6.5e-07 28.9 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 PIK57766.1 - 3.5e-05 24.0 0.5 8.8e-05 22.7 0.5 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 PIK57766.1 - 0.006 16.4 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 PIK57766.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 SH3 domain PSI_PsaF PF02507.15 PIK57766.1 - 0.067 13.0 0.5 0.18 11.6 0.5 1.7 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Docking PF08990.11 PIK57766.1 - 0.069 12.8 0.4 0.18 11.4 0.4 1.7 1 0 0 1 1 1 0 Erythronolide synthase docking FCH PF00611.23 PIK57766.1 - 0.076 13.3 0.1 0.076 13.3 0.1 2.7 3 1 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Glu-tRNAGln PF02686.15 PIK57766.1 - 0.14 12.5 0.3 0.47 10.8 0.3 1.9 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit DUF3713 PF12506.8 PIK57766.1 - 1.1 9.5 6.5 0.68 10.3 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3713) Methyltransf_8 PF05148.15 PIK57767.1 - 1.3e-55 188.6 0.1 1.5e-55 188.5 0.1 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 PIK57767.1 - 1.8e-09 38.1 0.0 1.1e-08 35.6 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK57767.1 - 1e-06 29.4 0.0 7.5e-05 23.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK57767.1 - 0.00013 21.8 0.1 0.054 13.3 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK57767.1 - 0.0012 18.7 0.0 0.0043 16.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK57767.1 - 0.0014 18.0 0.0 0.0032 16.9 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 PIK57767.1 - 0.0019 18.9 0.0 0.16 12.7 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 PIK57767.1 - 0.0029 17.2 0.0 0.63 9.6 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase small domain PUB PF09409.10 PIK57767.1 - 0.013 15.4 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 PUB domain NNMT_PNMT_TEMT PF01234.17 PIK57767.1 - 0.15 11.2 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Sushi PF00084.20 PIK57768.1 - 2.3e-59 197.8 116.0 8.8e-09 35.8 1.7 13.5 13 0 0 13 13 13 13 Sushi repeat (SCR repeat) HYR PF02494.16 PIK57768.1 - 9.6e-43 144.4 10.1 1.1e-13 51.3 1.0 4.8 4 0 0 4 4 4 4 HYR domain DUF5011 PF16403.5 PIK57768.1 - 0.0084 16.2 0.6 3.3 7.9 0.6 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF5011) Big_3_4 PF13754.6 PIK57768.1 - 0.083 12.6 0.0 2.3 8.0 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function Prenyltrans PF00432.21 PIK57768.1 - 0.28 11.0 4.4 9 6.1 0.2 4.0 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat Big_4 PF07532.11 PIK57768.1 - 1.6 8.5 3.9 0.83 9.4 0.5 2.1 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) EGF PF00008.27 PIK57769.1 - 2.5e-102 334.6 341.8 1.4e-09 38.1 6.1 25.8 23 1 1 24 24 24 22 EGF-like domain hEGF PF12661.7 PIK57769.1 - 1.1e-62 206.7 290.8 2.1e-06 28.2 3.9 25.9 23 1 0 23 23 22 18 Human growth factor-like EGF Ephrin_rec_like PF07699.13 PIK57769.1 - 5.1e-36 122.2 65.4 1.5e-11 43.9 2.2 8.4 5 2 2 7 7 6 5 Putative ephrin-receptor like HYR PF02494.16 PIK57769.1 - 2.3e-19 69.5 7.7 5.2e-11 42.7 1.0 4.1 3 0 0 3 3 3 3 HYR domain Laminin_G_3 PF13385.6 PIK57769.1 - 1.4e-14 54.5 0.2 2.4e-14 53.8 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily TSP_1 PF00090.19 PIK57769.1 - 1.3e-10 41.3 12.3 1.3e-10 41.3 12.3 6.7 6 1 1 7 7 1 1 Thrombospondin type 1 domain Pentaxin PF00354.17 PIK57769.1 - 1.7e-06 27.8 0.0 2.9e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family EGF_2 PF07974.13 PIK57769.1 - 0.0001 22.6 8.4 0.0001 22.6 8.4 26.5 26 1 0 26 26 24 14 EGF-like domain EGF_CA PF07645.15 PIK57769.1 - 0.0012 19.0 24.5 0.0022 18.2 8.2 27.8 17 6 10 27 27 24 11 Calcium-binding EGF domain EGF_3 PF12947.7 PIK57769.1 - 0.0063 16.7 6.3 0.0063 16.7 6.3 26.6 24 3 2 26 26 24 13 EGF domain Laminin_G_2 PF02210.24 PIK57769.1 - 0.015 15.9 0.1 0.027 15.0 0.1 1.4 1 0 0 1 1 1 0 Laminin G domain Laminin_G_1 PF00054.23 PIK57769.1 - 0.038 14.2 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain Toxin_R_bind_N PF07953.12 PIK57769.1 - 0.11 12.2 0.1 0.55 9.9 0.0 1.9 2 0 0 2 2 2 0 Clostridium neurotoxin, N-terminal receptor binding Mod_r PF07200.13 PIK57774.1 - 1.3e-14 54.5 4.7 2.3e-14 53.7 4.7 1.4 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein SHE3 PF17078.5 PIK57774.1 - 0.0012 18.7 0.7 0.002 17.9 0.7 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 RWD PF05773.22 PIK57774.1 - 0.029 14.7 0.1 0.097 13.0 0.0 2.0 2 0 0 2 2 2 0 RWD domain Snapin_Pallidin PF14712.6 PIK57774.1 - 0.074 13.5 1.0 0.16 12.4 1.0 1.5 1 0 0 1 1 1 0 Snapin/Pallidin UEV PF05743.13 PIK57774.1 - 0.089 12.7 2.0 0.36 10.7 2.0 2.0 1 1 0 1 1 1 0 UEV domain WD40 PF00400.32 PIK57775.1 - 2.4e-41 139.0 20.4 7.9e-11 42.3 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57775.1 - 6.3e-23 80.9 0.5 0.00022 21.4 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK57775.1 - 3.1e-09 36.3 2.5 0.0048 15.9 0.2 5.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK57775.1 - 1.1e-07 31.0 0.4 0.0063 15.2 0.2 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 PIK57775.1 - 3.1e-05 22.7 0.8 0.8 8.2 0.0 3.5 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nbas_N PF15492.6 PIK57775.1 - 0.00066 19.1 0.2 5.9 6.1 0.0 4.0 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal HPS3_N PF14761.6 PIK57775.1 - 0.0084 15.7 0.0 0.87 9.1 0.0 2.8 2 1 0 3 3 3 1 Hermansky-Pudlak syndrome 3 DUF5046 PF16465.5 PIK57775.1 - 0.016 14.6 0.0 0.13 11.7 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) PD40 PF07676.12 PIK57775.1 - 0.03 14.3 0.3 5 7.2 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 PIK57775.1 - 0.034 12.9 0.1 0.16 10.7 0.0 2.2 1 1 0 1 1 1 0 Nup133 N terminal like Frtz PF11768.8 PIK57775.1 - 0.047 12.0 0.0 0.076 11.3 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 PIK57775.1 - 0.06 12.3 0.2 16 4.3 0.1 3.0 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain LRR_9 PF14580.6 PIK57776.1 - 3.4e-14 52.7 1.3 1.1e-13 51.1 1.3 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK57776.1 - 2e-10 40.7 3.4 0.00019 21.8 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57776.1 - 0.055 13.3 7.8 0.31 10.8 0.3 3.0 2 1 1 3 3 3 0 Leucine rich repeat DUF2526 PF10735.9 PIK57776.1 - 0.057 13.6 0.1 0.088 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) Ras PF00071.22 PIK57777.1 - 3.9e-53 179.4 0.0 4.5e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK57777.1 - 5.6e-29 100.8 0.0 1e-28 100.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK57777.1 - 2.2e-08 33.8 0.0 2.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK57777.1 - 1.2e-06 28.6 0.0 1.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK57777.1 - 0.00022 20.8 0.0 0.0093 15.5 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK57777.1 - 0.0011 18.9 0.0 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 PIK57777.1 - 0.0012 18.2 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 PIK57777.1 - 0.018 14.6 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 PIK57777.1 - 0.04 13.3 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 PIK57777.1 - 0.046 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 PIK57777.1 - 0.048 14.0 0.0 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 PIK57777.1 - 0.051 12.7 2.0 1.7 7.7 0.3 2.5 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 PIK57777.1 - 0.056 13.0 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AIG1 PF04548.16 PIK57777.1 - 0.094 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family ABC_tran PF00005.27 PIK57777.1 - 0.47 11.0 1.6 1.5 9.4 1.6 2.1 1 1 0 1 1 1 0 ABC transporter ABC1 PF03109.16 PIK57778.1 - 1.1e-17 64.3 0.0 4.3e-17 62.4 0.0 2.1 2 1 0 2 2 2 1 ABC1 family DUF4649 PF15507.6 PIK57778.1 - 0.051 13.5 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4649) HAT_KAT11 PF08214.11 PIK57779.1 - 3.5e-65 220.6 1.4 3.5e-65 220.6 1.4 3.5 2 2 0 2 2 2 1 Histone acetylation protein KIX PF02172.16 PIK57779.1 - 6.2e-37 125.7 2.6 1.6e-36 124.4 2.6 1.7 1 0 0 1 1 1 1 KIX domain zf-TAZ PF02135.16 PIK57779.1 - 3.1e-28 98.0 66.6 5.8e-19 68.3 16.8 4.1 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.13 PIK57779.1 - 1.1e-21 77.0 7.9 1.1e-21 77.0 7.9 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 PIK57779.1 - 2.2e-14 53.2 0.2 6.8e-14 51.7 0.2 1.9 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.17 PIK57779.1 - 8.8e-14 51.0 12.2 8.8e-14 51.0 12.2 3.9 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.5 PIK57779.1 - 4.5e-05 23.4 0.9 4.5e-05 23.4 0.9 3.0 2 0 0 2 2 2 1 KIX domain Patched PF02460.18 PIK57780.1 - 8.8e-87 292.0 0.3 1e-86 291.8 0.3 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK57780.1 - 5.5e-41 140.0 3.2 5.5e-41 140.0 3.2 1.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK57780.1 - 5.2e-07 28.9 9.2 1.8e-06 27.1 7.9 2.1 2 0 0 2 2 2 1 MMPL family SecD_SecF PF02355.16 PIK57780.1 - 0.074 12.4 2.1 0.18 11.2 2.2 1.6 1 1 0 1 1 1 0 Protein export membrane protein DUF3267 PF11667.8 PIK57780.1 - 2.4 8.5 7.0 0.3 11.4 1.6 2.3 2 1 0 2 2 2 0 Putative zincin peptidase rve PF00665.26 PIK57781.1 - 3.9e-19 69.0 0.0 9e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Retrotran_gag_2 PF14223.6 PIK57781.1 - 8.1e-19 67.7 0.4 2.1e-18 66.3 0.2 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type RVT_2 PF07727.14 PIK57781.1 - 1.2e-15 57.8 0.0 2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 PIK57781.1 - 2.5e-05 24.0 0.4 0.00026 20.8 0.2 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 PIK57781.1 - 0.006 16.3 0.0 0.019 14.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 PIK57782.1 - 1.1e-41 143.1 0.1 1.8e-41 142.4 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SRA1 PF07304.11 PIK57782.1 - 4.9e-35 120.5 0.9 1.2e-34 119.2 0.9 1.6 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) AAA_23 PF13476.6 PIK57783.1 - 1.6e-13 51.6 60.7 1.6e-13 51.6 60.7 8.6 3 2 2 5 5 3 1 AAA domain Rad50_zn_hook PF04423.14 PIK57783.1 - 4.2e-10 39.3 0.1 4.2e-10 39.3 0.1 6.4 7 0 0 7 7 6 1 Rad50 zinc hook motif AAA_21 PF13304.6 PIK57783.1 - 9.2e-10 38.8 3.3 0.00087 19.2 0.0 3.8 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 PIK57783.1 - 2.1e-08 34.3 3.2 2.1e-08 34.3 3.2 5.4 1 1 3 5 5 2 2 AAA ATPase domain SMC_N PF02463.19 PIK57783.1 - 1.1e-07 31.5 0.0 1.1e-07 31.5 0.0 3.1 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 PIK57783.1 - 1.8e-05 24.9 0.0 0.00016 21.8 0.0 2.5 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 PIK57783.1 - 0.007 16.1 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 PIK57783.1 - 0.093 13.2 0.0 0.093 13.2 0.0 8.1 3 1 1 4 4 2 0 ABC transporter AAA_13 PF13166.6 PIK57783.1 - 0.1 11.3 0.0 0.1 11.3 0.0 7.4 4 1 1 6 6 5 0 AAA domain AAA_16 PF13191.6 PIK57783.1 - 0.56 10.6 0.0 0.56 10.6 0.0 4.7 5 2 1 6 6 6 0 AAA ATPase domain DASH_Dam1 PF08653.10 PIK57783.1 - 3.4 7.5 8.8 4.3 7.2 0.3 4.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 DUF2012 PF09430.10 PIK57784.1 - 0.00087 19.4 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) DUF2012 PF09430.10 PIK57785.1 - 4.8e-24 84.8 0.0 8.7e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Tho2 PF11262.8 PIK57786.1 - 2.3e-60 204.3 10.6 1.6e-34 119.5 0.6 6.3 5 1 1 6 6 6 3 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 PIK57787.1 - 1.9e-74 251.5 10.9 2e-48 165.5 7.8 3.0 1 1 1 2 2 2 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 PIK57787.1 - 1.5e-35 121.0 0.1 3.7e-35 119.8 0.1 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit TPR_19 PF14559.6 PIK57787.1 - 0.025 15.1 0.0 0.058 13.9 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat RolB_RolC PF02027.17 PIK57787.1 - 0.086 12.5 2.3 0.31 10.7 0.2 2.2 1 1 1 2 2 2 0 RolB/RolC glucosidase family Peptidase_A17 PF05380.13 PIK57788.1 - 0.0062 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK57789.1 - 1.4e-05 24.7 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lectin_C PF00059.21 PIK57790.1 - 7.3e-11 42.8 0.2 1.5e-10 41.7 0.0 1.6 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.12 PIK57790.1 - 0.24 11.0 0.1 0.92 9.1 0.1 1.8 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK57791.1 - 1.7e-16 60.9 0.1 2.2e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Lectin C-type domain DUF4994 PF16385.5 PIK57791.1 - 0.081 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function MFS_1_like PF12832.7 PIK57792.1 - 4.9e-64 216.6 11.7 2.7e-38 131.8 1.5 2.1 1 1 1 2 2 2 2 MFS_1 like family MFS_1 PF07690.16 PIK57792.1 - 2.6e-21 75.9 21.8 1.6e-12 47.1 11.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 PIK57792.1 - 1.9e-14 53.3 10.7 2.7e-06 26.4 0.2 3.2 3 0 0 3 3 3 3 LacY proton/sugar symporter Nuc_H_symport PF03825.16 PIK57792.1 - 5.7e-06 25.6 6.2 6e-05 22.2 0.9 2.5 2 1 0 2 2 2 2 Nucleoside H+ symporter MFS_3 PF05977.13 PIK57792.1 - 0.037 12.4 2.6 0.55 8.6 0.4 2.7 3 0 0 3 3 3 0 Transmembrane secretion effector Neurochondrin PF05536.11 PIK57793.1 - 5.2e-103 345.5 14.5 6.9e-103 345.1 14.5 1.0 1 0 0 1 1 1 1 Neurochondrin DUF4042 PF13251.6 PIK57793.1 - 0.0031 17.2 1.1 3.6 7.3 0.4 3.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4042) CS PF04969.16 PIK57794.1 - 4.9e-17 62.7 0.2 7e-17 62.2 0.2 1.2 1 0 0 1 1 1 1 CS domain RuvB_N PF05496.12 PIK57794.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Nup96 PF12110.8 PIK57796.1 - 0.039 13.1 1.0 0.4 9.8 0.4 2.3 1 1 1 2 2 2 0 Nuclear protein 96 TPR_14 PF13428.6 PIK57796.1 - 0.39 11.7 2.3 9.9 7.3 0.0 3.4 2 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 PIK57797.1 - 1.3e-09 38.5 3.4 0.029 15.2 0.0 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK57797.1 - 1.7e-09 37.8 0.0 0.002 18.4 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain UQ_con PF00179.26 PIK57800.1 - 0.0044 16.7 0.0 0.0067 16.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Corona_NS1 PF06145.11 PIK57800.1 - 0.064 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Coronavirus nonstructural protein NS1 FXR_C1 PF16096.5 PIK57801.1 - 0.045 14.0 1.9 0.045 14.0 1.9 1.8 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Fibrinogen_C PF00147.18 PIK57802.1 - 2.5e-57 194.2 2.5 3.2e-57 193.9 2.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Y_phosphatase PF00102.27 PIK57803.1 - 3.5e-71 239.5 1.0 4.2e-71 239.2 1.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK57803.1 - 0.0001 22.1 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK57803.1 - 0.0095 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK57803.1 - 0.028 14.5 0.1 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate BRO1 PF03097.18 PIK57805.1 - 5.4e-114 381.0 4.2 5.4e-114 381.0 4.2 2.0 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 PIK57805.1 - 1.1e-55 189.1 20.1 1.1e-55 189.1 20.1 2.2 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV Y_phosphatase3 PF13350.6 PIK57805.1 - 0.0072 16.3 1.1 0.34 10.9 0.3 2.7 2 0 0 2 2 2 1 Tyrosine phosphatase family ROS_MUCR PF05443.11 PIK57805.1 - 1.4 9.0 6.8 33 4.5 6.8 3.1 1 1 0 1 1 1 0 ROS/MUCR transcriptional regulator protein Actin PF00022.19 PIK57806.1 - 8.9e-87 291.3 0.0 2.4e-56 191.1 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 PIK57806.1 - 0.00011 21.1 0.0 0.077 11.8 0.0 2.6 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 PIK57806.1 - 0.0093 16.4 0.0 0.036 14.5 0.0 2.1 2 1 0 2 2 2 1 Cell division protein FtsA tRNA_anti-codon PF01336.25 PIK57807.1 - 0.00044 20.2 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 PIK57807.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 Ion_trans PF00520.31 PIK57808.1 - 1.8e-28 99.4 9.9 2.3e-28 99.0 9.9 1.1 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK57808.1 - 2.8e-10 40.1 0.0 6.9e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK57808.1 - 5.9e-10 39.0 1.1 5.9e-10 39.0 1.1 2.5 3 0 0 3 3 3 1 Ion channel UBM PF14377.6 PIK57808.1 - 0.033 13.6 0.4 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin binding region BLOC1S3 PF15753.5 PIK57808.1 - 0.088 12.9 1.5 0.16 12.0 1.5 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF3099 PF11298.8 PIK57808.1 - 1.8 8.7 5.7 0.21 11.7 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) Il2rg PF15874.5 PIK57809.1 - 8.5e-17 61.2 0.0 1.4e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain zf-H2C2_2 PF13465.6 PIK57810.1 - 3.5e-08 33.5 1.2 3.5e-08 33.5 1.2 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK57810.1 - 5.4e-08 32.9 12.8 9.3e-06 25.8 3.5 3.6 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK57810.1 - 4.9e-05 23.8 20.6 7.8e-05 23.2 2.0 3.8 2 1 1 3 3 3 2 C2H2-type zinc finger TF_Zn_Ribbon PF08271.12 PIK57810.1 - 0.018 14.5 4.3 2 8.0 1.6 2.7 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4428 PF14471.6 PIK57810.1 - 0.074 13.0 0.4 0.29 11.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) Actin_micro PF17003.5 PIK57810.1 - 0.11 11.7 1.0 0.15 11.2 1.0 1.2 1 0 0 1 1 1 0 Putative actin-like family zf_C2H2_ZHX PF18387.1 PIK57810.1 - 0.12 12.0 2.6 0.3 10.8 0.5 2.5 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-LYAR PF08790.11 PIK57810.1 - 0.14 12.1 1.8 0.27 11.2 0.8 2.1 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-trcl PF13451.6 PIK57810.1 - 0.42 10.6 0.3 0.42 10.6 0.3 3.0 3 1 0 3 3 3 0 Probable zinc-ribbon domain PHD_Oberon PF07227.11 PIK57810.1 - 1.4 8.8 9.5 12 5.7 9.5 2.0 1 1 0 1 1 1 0 PHD - plant homeodomain finger protein UPF0449 PF15136.6 PIK57811.1 - 0.73 10.3 4.5 2.1 8.8 3.3 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 TSC22 PF01166.18 PIK57811.1 - 6.7 7.1 8.3 0.67 10.3 2.6 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family RsfS PF02410.15 PIK57813.1 - 5.6e-28 97.3 0.2 1e-27 96.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Sulfotransfer_2 PF03567.14 PIK57814.1 - 3.1e-45 155.1 2.5 4.1e-45 154.7 2.5 1.2 1 0 0 1 1 1 1 Sulfotransferase family DUF2116 PF09889.9 PIK57814.1 - 0.25 11.4 0.7 0.58 10.2 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) ATP19 PF11022.8 PIK57815.1 - 0.031 14.6 0.1 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase subunit K RIIa PF02197.17 PIK57815.1 - 0.042 13.5 0.1 0.085 12.5 0.1 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Dpy-30 PF05186.13 PIK57815.1 - 0.093 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif SapB_1 PF05184.15 PIK57815.1 - 0.15 12.1 0.5 23 5.1 0.2 2.9 2 0 0 2 2 2 0 Saposin-like type B, region 1 p450 PF00067.22 PIK57816.1 - 5.2e-69 233.2 0.0 6.7e-69 232.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 IFN-gamma PF00714.17 PIK57816.1 - 0.0037 17.1 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 Interferon gamma Hormone_recep PF00104.30 PIK57817.1 - 7.6e-10 38.7 0.0 1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF3014 PF11219.8 PIK57818.1 - 0.037 14.3 0.0 0.052 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3014) MG3 PF17791.1 PIK57819.1 - 2.1e-19 69.5 0.0 6.4e-18 64.8 0.0 2.9 3 0 0 3 3 3 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK57819.1 - 1.7e-08 34.5 0.0 3.5e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Macroglobulin domain MG4 MG2 PF01835.19 PIK57819.1 - 0.0026 18.2 0.0 6.3 7.3 0.0 3.0 3 0 0 3 3 3 2 MG2 domain A2M_BRD PF07703.14 PIK57820.1 - 6.1e-20 72.0 0.0 8.5e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain TED_complement PF07678.14 PIK57821.1 - 2.5e-37 128.6 0.0 6e-32 110.9 0.0 2.6 2 1 1 3 3 3 2 A-macroglobulin TED domain A2M_recep PF07677.14 PIK57822.1 - 8.7e-17 61.6 0.5 1.2e-16 61.1 0.5 1.2 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain NACHT PF05729.12 PIK57823.1 - 1.8e-16 60.5 0.0 5.3e-16 59.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Ig_3 PF13927.6 PIK57823.1 - 6.1e-06 26.7 2.8 0.15 12.7 0.0 4.4 3 1 1 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK57823.1 - 1.7e-05 24.8 1.0 0.046 13.8 0.1 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK57823.1 - 0.00026 21.2 1.1 2.2 8.7 0.0 4.1 3 1 1 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK57823.1 - 0.0049 17.0 1.4 1.9 8.7 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain AAA_25 PF13481.6 PIK57823.1 - 0.0067 16.0 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain V-set PF07686.17 PIK57823.1 - 0.0083 16.3 0.0 0.063 13.5 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 PIK57823.1 - 0.0087 16.4 1.9 0.4 11.1 0.5 3.2 3 0 0 3 3 2 1 Immunoglobulin C1-set domain I-set PF07679.16 PIK57823.1 - 0.021 14.9 0.1 5.4 7.1 0.0 3.3 3 0 0 3 3 3 0 Immunoglobulin I-set domain AAA_16 PF13191.6 PIK57823.1 - 0.032 14.6 0.0 0.099 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 PIK57823.1 - 0.045 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Il13Ra_Ig PF18001.1 PIK57823.1 - 0.11 12.6 0.8 2 8.6 0.1 2.9 3 0 0 3 3 3 0 Interleukin-13 receptor subunit alpha Ig-like domain DNA_methylase PF00145.17 PIK57824.1 - 3.9e-24 85.6 0.6 5.2e-24 85.2 0.6 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Vps26 PF03643.15 PIK57825.1 - 1.9e-101 338.7 9.1 4.5e-99 330.9 9.1 2.0 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 PIK57825.1 - 0.00069 19.7 2.1 0.38 10.8 0.0 3.5 3 1 1 4 4 4 2 Arrestin (or S-antigen), N-terminal domain RAWUL PF16207.5 PIK57826.1 - 4.8e-20 72.0 0.0 6.1e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like DUF3337 PF11816.8 PIK57826.1 - 0.034 14.0 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) zf-C3HC4_2 PF13923.6 PIK57827.1 - 8.3e-16 57.5 10.8 1.3e-15 56.9 10.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK57827.1 - 1.9e-09 37.2 11.0 3e-09 36.6 11.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK57827.1 - 3.3e-09 36.9 9.0 5.4e-09 36.2 9.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK57827.1 - 2.6e-07 30.4 8.3 3.7e-07 29.9 8.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK57827.1 - 7.8e-06 25.7 9.3 1.3e-05 25.1 9.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK57827.1 - 1.1e-05 25.3 8.5 2.3e-05 24.3 8.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 PIK57827.1 - 0.00023 20.9 5.8 0.0004 20.1 5.8 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 PIK57827.1 - 0.00047 20.3 8.9 0.00081 19.5 8.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 PIK57827.1 - 0.0036 17.5 8.4 0.016 15.5 8.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 PIK57827.1 - 0.0042 16.8 9.1 0.013 15.3 9.3 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 PIK57827.1 - 0.0059 16.4 3.4 0.0097 15.8 3.4 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-UDP PF14569.6 PIK57827.1 - 0.044 13.9 4.7 0.11 12.7 4.7 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 PIK57827.1 - 0.056 13.3 9.2 1.8 8.5 9.7 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 PIK57827.1 - 0.078 12.9 8.5 0.48 10.4 8.5 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 PIK57827.1 - 0.39 10.8 3.6 0.99 9.5 3.6 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C4_Topoisom PF01396.19 PIK57827.1 - 0.45 10.3 3.7 0.18 11.6 0.9 1.7 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-RING_10 PF16685.5 PIK57827.1 - 0.54 10.4 7.2 0.91 9.7 7.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 SBP PF03110.14 PIK57827.1 - 1 9.7 6.4 0.11 12.9 1.9 1.7 2 0 0 2 2 2 0 SBP domain zf-MIZ PF02891.20 PIK57827.1 - 1.7 8.5 7.4 3.3 7.5 7.4 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger DZR PF12773.7 PIK57827.1 - 3.1 7.9 7.5 41 4.3 7.5 2.4 1 1 1 2 2 2 0 Double zinc ribbon PTCB-BRCT PF12738.7 PIK57828.1 - 1.1e-48 163.0 5.2 3.6e-20 71.7 0.0 5.3 5 0 0 5 5 5 5 twin BRCT domain BRCT PF00533.26 PIK57828.1 - 4.3e-44 148.8 14.6 8e-12 45.4 0.0 6.0 7 0 0 7 7 5 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK57828.1 - 6.2e-31 106.7 4.3 4e-07 30.4 0.0 6.3 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK57828.1 - 1.8e-19 69.4 5.1 2.9e-13 49.5 0.0 5.1 5 1 1 6 6 5 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 PIK57828.1 - 4.6e-09 36.4 12.6 0.031 14.6 0.0 5.0 5 0 0 5 5 4 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 PIK57828.1 - 6.1e-07 29.5 2.4 0.055 13.5 0.0 4.5 6 0 0 6 6 6 2 BRCA1 C Terminus (BRCT) domain Thioredoxin_8 PF13905.6 PIK57828.1 - 0.025 14.9 0.0 0.16 12.3 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like SRP-alpha_N PF04086.13 PIK57828.1 - 0.3 11.0 18.0 0.62 9.9 18.0 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDK2AP PF09806.9 PIK57828.1 - 1.7 8.7 6.9 22 5.0 5.6 2.3 1 1 1 2 2 2 0 Cyclin-dependent kinase 2-associated protein SAPS PF04499.15 PIK57828.1 - 6.1 5.5 8.0 9.6 4.9 8.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 PIK57828.1 - 8.8 5.4 8.5 16 4.6 6.6 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter SLC12 PF03522.15 PIK57828.1 - 9.2 5.2 8.6 15 4.4 8.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CC2-LZ PF16516.5 PIK57829.1 - 0.00048 20.4 35.4 0.00079 19.8 2.2 3.9 2 1 0 3 3 3 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator TMEM173 PF15009.6 PIK57829.1 - 0.028 13.6 1.4 0.062 12.5 1.4 1.5 1 0 0 1 1 1 0 Transmembrane protein 173 Death PF00531.22 PIK57830.1 - 0.025 14.7 0.8 0.082 13.1 0.3 2.1 1 1 2 3 3 3 0 Death domain CLCA PF08434.11 PIK57831.1 - 7e-64 215.7 0.0 8.7e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Peptidase_M64 PF09471.10 PIK57831.1 - 0.75 9.3 3.1 0.98 8.9 1.8 1.8 1 1 1 2 2 2 0 IgA Peptidase M64 VWA_2 PF13519.6 PIK57832.1 - 5.3e-11 43.1 0.0 1.1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 PIK57832.1 - 1.7e-09 38.2 0.0 2.7e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK57832.1 - 0.0005 19.5 0.1 0.00084 18.8 0.1 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF997 PF06196.12 PIK57832.1 - 0.00089 19.2 0.1 0.0017 18.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF997) LRR_9 PF14580.6 PIK57835.1 - 1.4e-13 50.7 3.0 3.1e-13 49.6 3.0 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 PIK57835.1 - 1.3e-10 41.4 8.6 1.3e-05 25.4 0.3 2.9 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK57835.1 - 0.0019 17.9 9.4 0.016 14.9 1.0 3.1 2 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 PIK57835.1 - 0.015 15.3 8.7 3.3 8.0 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat ERAP1_C PF11838.8 PIK57836.1 - 8.6e-82 275.2 1.5 1.4e-81 274.5 1.5 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 PIK57836.1 - 2.8e-81 272.2 1.9 4.7e-81 271.5 1.9 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 PIK57836.1 - 3e-36 125.4 0.2 6.8e-36 124.2 0.1 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain BSP PF04450.12 PIK57836.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase of plants and bacteria CH PF00307.31 PIK57837.1 - 0.0038 17.4 0.1 0.0057 16.8 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF3952 PF13130.6 PIK57837.1 - 0.051 13.8 0.3 0.64 10.2 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3952) Amidohydro_2 PF04909.14 PIK57838.1 - 2.7e-44 152.1 0.5 3.1e-44 151.9 0.5 1.0 1 0 0 1 1 1 1 Amidohydrolase ETC_C1_NDUFA4 PF04800.12 PIK57838.1 - 0.024 14.9 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 ETC complex I subunit conserved region Peptidase_M19 PF01244.21 PIK57838.1 - 0.065 12.4 0.0 0.3 10.2 0.0 2.0 1 1 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) P4Ha_N PF08336.11 PIK57839.1 - 0.023 14.7 1.7 0.023 14.7 1.7 2.4 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF313 PF03754.13 PIK57839.1 - 0.025 14.8 1.3 0.67 10.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF313) EMP24_GP25L PF01105.24 PIK57839.1 - 1.9 8.4 10.3 0.14 12.1 2.6 2.4 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD GST_C PF00043.25 PIK57840.1 - 4.4e-07 30.0 0.0 5.5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK57840.1 - 1.2e-05 25.4 0.0 1.7e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK57840.1 - 0.00057 19.8 0.1 0.0017 18.3 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain AP_endonuc_2 PF01261.24 PIK57840.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Mis12 PF05859.12 PIK57840.1 - 0.17 11.9 0.0 0.26 11.4 0.0 1.5 1 1 0 1 1 1 0 Mis12 protein OGG_N PF07934.12 PIK57841.1 - 1.8e-23 82.9 0.1 2.7e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain Hamartin PF04388.12 PIK57843.1 - 7.8e-30 104.2 0.1 7.8e-30 104.2 0.1 2.6 3 0 0 3 3 3 1 Hamartin protein PKcGMP_CC PF16808.5 PIK57843.1 - 0.49 10.3 0.0 0.49 10.3 0.0 3.8 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Hamartin PF04388.12 PIK57844.1 - 4.1e-121 406.0 0.1 4.9e-121 405.7 0.1 1.0 1 0 0 1 1 1 1 Hamartin protein DnaJ_CXXCXGXG PF00684.19 PIK57845.1 - 0.033 14.6 1.2 0.045 14.1 0.2 1.7 2 0 0 2 2 2 0 DnaJ central domain HalX PF08663.10 PIK57845.1 - 0.049 13.9 11.7 0.38 11.1 1.8 2.6 2 0 0 2 2 2 0 HalX domain Cep57_CLD_2 PF14197.6 PIK57845.1 - 0.07 13.2 14.4 0.88 9.7 2.0 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Ribosomal_L29 PF00831.23 PIK57845.1 - 0.082 12.9 2.2 2.4 8.2 0.9 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein DUF2367 PF10164.9 PIK57845.1 - 0.25 11.9 1.2 0.83 10.2 1.2 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Csm1_N PF18504.1 PIK57845.1 - 0.26 11.6 7.8 5.7 7.4 1.9 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain APG6_N PF17675.1 PIK57845.1 - 0.39 11.2 6.3 6.8 7.2 0.3 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 PIK57845.1 - 0.73 9.1 6.7 1.9 7.7 6.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 PIK57845.1 - 1.1 9.7 10.9 0.64 10.4 8.1 2.0 1 1 1 2 2 2 0 Fez1 BST2 PF16716.5 PIK57845.1 - 1.3 9.6 7.1 8.5 7.0 0.6 2.4 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 PIK57845.1 - 5.2 7.1 9.5 5.5 7.1 1.6 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 PIK57845.1 - 9.4 6.5 10.1 21 5.4 3.4 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding AKNA PF12443.8 PIK57846.1 - 7.1e-07 29.8 1.1 7.1e-07 29.8 1.1 4.0 4 0 0 4 4 4 1 AT-hook-containing transcription factor ATG16 PF08614.11 PIK57846.1 - 0.0037 17.5 1.9 0.0037 17.5 1.9 4.6 4 1 1 5 5 5 1 Autophagy protein 16 (ATG16) MukF_M PF17192.4 PIK57846.1 - 0.016 15.0 0.3 0.037 13.8 0.3 1.6 1 0 0 1 1 1 0 MukF middle domain PvlArgDC PF01862.16 PIK57846.1 - 0.092 12.5 0.2 0.27 11.0 0.2 1.7 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Ank_4 PF13637.6 PIK57848.1 - 3.2e-06 27.6 0.5 2.9e-05 24.5 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK57848.1 - 7.1e-06 26.5 0.0 3.8e-05 24.2 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK57848.1 - 2.8e-05 24.2 0.1 0.0049 17.3 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 PIK57848.1 - 0.00015 22.1 1.3 0.11 13.0 0.3 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK57848.1 - 0.00076 19.7 0.2 0.0025 18.1 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF3437 PF11919.8 PIK57848.1 - 0.013 15.4 5.0 2.4 8.1 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) DnaI_N PF07319.11 PIK57848.1 - 0.02 15.6 0.6 0.18 12.5 0.0 2.5 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus Feld-I_B PF09252.10 PIK57849.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Allergen Fel d I-B chain MethyltransfD12 PF02086.15 PIK57849.1 - 0.13 11.9 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Bclx_interact PF08945.10 PIK57849.1 - 0.27 11.0 3.1 0.55 10.0 3.1 1.4 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain RVT_1 PF00078.27 PIK57851.1 - 1.1e-08 34.9 0.0 2e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK57852.1 - 2.5e-28 98.0 0.0 3.8e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57852.1 - 9.8e-26 90.1 0.0 1.4e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase FERM_C PF09380.10 PIK57853.1 - 0.047 14.1 0.0 0.093 13.1 0.0 1.5 1 0 0 1 1 1 0 FERM C-terminal PH-like domain SH3_1 PF00018.28 PIK57854.1 - 5.9e-09 35.4 0.0 1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK57854.1 - 4e-08 33.0 0.1 7.3e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK57854.1 - 3.9e-06 26.5 0.0 6.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK57854.1 - 9.7e-06 25.8 0.0 2.2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain HR1 PF02185.16 PIK57854.1 - 2.9e-05 24.1 0.2 6e-05 23.1 0.2 1.6 1 0 0 1 1 1 1 Hr1 repeat MtrG PF04210.13 PIK57854.1 - 0.0094 15.8 0.2 6.9 6.6 0.1 2.5 2 0 0 2 2 2 2 Tetrahydromethanopterin S-methyltransferase, subunit G Fungal_TACC PF12709.7 PIK57854.1 - 0.027 14.9 2.0 0.027 14.9 2.0 2.2 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Uds1 PF15456.6 PIK57854.1 - 0.13 12.4 1.3 0.32 11.2 1.3 1.7 1 1 0 1 1 1 0 Up-regulated During Septation FCH PF00611.23 PIK57855.1 - 9.6e-17 61.0 0.9 2.8e-16 59.5 0.9 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Band_3_cyto PF07565.13 PIK57855.1 - 0.034 14.0 2.6 0.048 13.4 2.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Thioredoxin_4 PF13462.6 PIK57855.1 - 0.067 13.3 3.0 0.13 12.4 3.0 1.4 1 0 0 1 1 1 0 Thioredoxin Methyltrn_RNA_3 PF02598.17 PIK57856.1 - 6.9e-78 262.0 0.0 9.7e-78 261.6 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase DUF1905 PF08922.11 PIK57856.1 - 0.091 12.8 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1905) PTPA PF03095.15 PIK57857.1 - 2.2e-98 329.4 3.1 5.4e-72 242.8 1.3 2.0 1 1 1 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein TRM PF02005.16 PIK57858.1 - 4.7e-56 190.6 0.9 7.7e-53 180.0 0.1 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_31 PF13847.6 PIK57858.1 - 0.012 15.4 0.1 0.026 14.3 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 PIK57858.1 - 0.021 14.6 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein RT_RNaseH_2 PF17919.1 PIK57859.1 - 2.6e-27 94.8 0.0 4.6e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK57859.1 - 5.6e-24 84.4 0.0 9.7e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK57859.1 - 1.7e-16 60.4 0.0 2.7e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK57859.1 - 4e-15 55.7 0.3 7.4e-15 54.8 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain AAA_11 PF13086.6 PIK57862.1 - 2.5e-26 93.0 0.0 1e-12 48.5 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 PIK57862.1 - 5.5e-07 29.5 0.0 3.6e-06 26.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK57862.1 - 9e-06 25.8 0.0 2.4e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 PIK57862.1 - 2.5e-05 24.0 0.0 5.6e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 PIK57862.1 - 3.1e-05 24.3 0.0 8.2e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 PIK57862.1 - 0.004 16.9 0.6 4.4 7.0 0.0 3.1 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_RecD PF05127.14 PIK57862.1 - 0.017 15.0 0.0 0.11 12.4 0.0 2.1 1 1 0 1 1 1 0 Helicase Papilloma_E5A PF05776.12 PIK57862.1 - 0.022 15.1 1.0 0.065 13.6 1.0 1.8 1 0 0 1 1 1 0 Papillomavirus E5A protein PhoH PF02562.16 PIK57862.1 - 0.046 13.2 0.0 3.7 6.9 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein RNB PF00773.19 PIK57863.1 - 1.2e-30 106.9 0.0 1.1e-23 84.1 0.0 2.5 1 1 1 2 2 2 2 RNB domain AAA_12 PF13087.6 PIK57863.1 - 2.9e-23 82.6 0.2 5.3e-23 81.7 0.2 1.5 1 0 0 1 1 1 1 AAA domain OB_Dis3 PF17849.1 PIK57863.1 - 0.0041 17.1 0.0 0.013 15.5 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 PIK57863.1 - 0.0071 16.5 0.0 4.6 7.5 0.0 2.9 2 0 0 2 2 2 2 Cold shock domain UvrD_C_2 PF13538.6 PIK57863.1 - 0.055 13.3 1.1 7.6 6.4 0.1 2.7 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 PIK57864.1 - 1e-46 159.8 0.0 1.7e-46 159.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 PIK57864.1 - 7.7e-46 156.2 0.2 2.1e-44 151.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK57864.1 - 2.5e-12 46.9 0.0 3.9e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 PIK57864.1 - 5.1e-09 36.6 0.0 4.5e-08 33.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 PIK57864.1 - 1.4e-05 24.8 0.1 0.0012 18.6 0.0 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 PIK57864.1 - 2.6e-05 24.5 0.0 0.0023 18.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 PIK57864.1 - 3.3e-05 23.7 0.3 0.48 10.1 0.0 3.4 3 1 1 4 4 4 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 PIK57864.1 - 0.0002 20.7 0.7 2.2 7.4 0.1 3.4 3 1 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) UvrD_C PF13361.6 PIK57864.1 - 0.014 14.8 0.9 0.026 13.9 0.9 1.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 PIK57864.1 - 0.042 13.9 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ResIII PF04851.15 PIK57864.1 - 0.055 13.5 0.0 23 4.9 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit PhoH PF02562.16 PIK57864.1 - 0.065 12.7 0.0 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 PIK57864.1 - 0.091 13.3 0.0 1.4 9.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 PIK57864.1 - 0.14 11.9 0.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_12 PF13087.6 PIK57866.1 - 1.5e-31 109.6 1.4 2.4e-31 108.9 0.2 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK57866.1 - 2.7e-26 92.9 1.0 4e-13 49.8 0.1 2.9 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 PIK57866.1 - 5.9e-06 26.1 0.0 3.4e-05 23.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 PIK57866.1 - 2.8e-05 24.2 0.0 8.7e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 PIK57866.1 - 5.5e-05 22.8 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 PIK57866.1 - 5.9e-05 23.4 0.0 0.00089 19.6 0.0 2.7 2 2 0 2 2 2 1 AAA domain DEAD PF00270.29 PIK57866.1 - 0.0082 15.9 1.3 10 5.9 0.0 3.6 4 0 0 4 4 4 2 DEAD/DEAH box helicase zf-C2H2_4 PF13894.6 PIK57866.1 - 0.041 14.7 0.4 0.25 12.3 0.4 2.5 1 0 0 1 1 1 0 C2H2-type zinc finger UvrD_C_2 PF13538.6 PIK57866.1 - 0.059 13.2 1.1 2.1 8.2 0.1 2.6 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 PIK57866.1 - 0.063 13.1 0.0 0.3 10.9 0.0 2.1 1 1 0 1 1 1 0 Helicase DUF2183 PF09949.9 PIK57866.1 - 0.17 12.2 0.3 1.6 9.1 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2183) RNB PF00773.19 PIK57867.1 - 4.6e-74 249.7 0.0 1.5e-73 248.0 0.0 1.9 1 1 0 1 1 1 1 RNB domain AAA_11 PF13086.6 PIK57867.1 - 8.3e-16 58.5 0.0 1.9e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK57867.1 - 0.00056 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK57867.1 - 0.00071 19.9 0.0 0.0018 18.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain OB_Dis3 PF17849.1 PIK57867.1 - 0.0046 16.9 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) AAA_22 PF13401.6 PIK57867.1 - 0.027 14.7 0.0 0.13 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF4138 PF13595.6 PIK57867.1 - 0.044 13.0 0.1 0.086 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) PhoH PF02562.16 PIK57867.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_12 PF13087.6 PIK57868.1 - 1.5e-26 93.3 1.3 2.3e-17 63.3 0.0 2.3 1 1 1 2 2 2 2 AAA domain RasGEF PF00617.19 PIK57869.1 - 3.7e-43 147.8 0.9 1.3e-42 146.0 0.9 1.8 1 1 0 1 1 1 1 RasGEF domain PH PF00169.29 PIK57869.1 - 0.018 15.6 0.4 0.041 14.4 0.4 1.6 1 0 0 1 1 1 0 PH domain rve PF00665.26 PIK57870.1 - 5e-17 62.2 0.0 6.6e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK57870.1 - 0.0022 17.7 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK57870.1 - 0.22 12.0 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 MycE methyltransferase N-terminal Integrase_H2C2 PF17921.1 PIK57871.1 - 1.3e-18 66.9 1.0 3.2e-18 65.6 1.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK57871.1 - 0.0012 19.1 0.6 0.0012 19.1 0.6 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Speriolin_N PF15058.6 PIK57871.1 - 0.26 11.3 3.3 1.2 9.1 3.3 2.0 1 1 0 1 1 1 0 Speriolin N terminus RabGAP-TBC PF00566.18 PIK57872.1 - 3.2e-29 102.1 0.0 7.9e-29 100.8 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Tropomyosin PF00261.20 PIK57872.1 - 0.00085 18.8 13.9 0.0053 16.2 4.4 2.3 2 0 0 2 2 2 2 Tropomyosin HOOK PF05622.12 PIK57872.1 - 0.0014 16.9 17.5 0.025 12.8 6.2 2.2 1 1 1 2 2 2 2 HOOK protein Lebercilin PF15619.6 PIK57872.1 - 0.17 11.5 18.6 9.3 5.9 18.3 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Noelin-1 PF12308.8 PIK57872.1 - 0.19 11.8 7.8 0.064 13.2 2.6 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein DUF724 PF05266.14 PIK57872.1 - 0.26 11.1 12.9 4.3 7.1 13.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF724) TSC22 PF01166.18 PIK57872.1 - 0.39 11.1 6.5 0.96 9.8 0.1 3.3 1 1 2 3 3 3 0 TSC-22/dip/bun family Viral_P18 PF04521.13 PIK57872.1 - 0.4 10.5 3.3 1.7 8.5 0.0 2.8 3 1 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein CorA PF01544.18 PIK57872.1 - 3.5 6.9 7.3 8.2 5.6 7.3 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein RabGAP-TBC PF00566.18 PIK57873.1 - 5e-05 23.1 0.3 5e-05 23.1 0.3 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain NTP_transf_8 PF12281.8 PIK57876.1 - 0.099 12.6 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Nucleotidyltransferase NACHT PF05729.12 PIK57879.1 - 1.7e-05 24.8 0.0 2.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK57879.1 - 0.0069 16.0 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain Ephrin_rec_like PF07699.13 PIK57880.1 - 1.9e-06 27.5 4.4 1.9e-06 27.5 4.4 3.6 1 1 2 3 3 3 3 Putative ephrin-receptor like NCD3G PF07562.14 PIK57880.1 - 0.29 11.1 12.3 0.8 9.7 0.6 3.1 2 1 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR Pkinase_Tyr PF07714.17 PIK57881.1 - 1.3e-31 109.8 0.0 2e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK57881.1 - 1.2e-23 83.8 0.1 1.8e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK57881.1 - 3.1e-09 36.8 1.3 9.2e-06 25.6 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK57881.1 - 0.00024 21.4 0.2 0.0015 18.9 0.0 2.4 2 1 1 3 3 3 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK57881.1 - 0.00064 20.3 4.0 0.21 12.2 0.1 3.3 3 0 0 3 3 3 2 Immunoglobulin domain YpmT PF17431.2 PIK57881.1 - 0.12 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized YmpT-like ig PF00047.25 PIK57881.1 - 0.37 11.0 3.7 1.4 9.2 0.0 3.3 3 1 0 4 4 4 0 Immunoglobulin domain Dam PF05869.11 PIK57882.1 - 0.03 13.9 0.1 0.055 13.0 0.1 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) DUF2043 PF09740.9 PIK57882.1 - 0.16 12.7 2.8 0.24 12.1 2.2 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) NACHT PF05729.12 PIK57883.1 - 5e-15 55.8 0.0 9.7e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain TMEM154 PF15102.6 PIK57883.1 - 2.2e-07 30.8 0.2 4.7e-07 29.8 0.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 PIK57883.1 - 2.1e-06 28.3 3.2 0.049 14.2 0.0 4.9 4 1 1 5 5 5 1 Immunoglobulin domain V-set PF07686.17 PIK57883.1 - 0.00027 21.1 0.2 0.055 13.7 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain SKG6 PF08693.10 PIK57883.1 - 0.0017 17.7 4.0 0.0036 16.7 4.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Herpes_gE PF02480.16 PIK57883.1 - 0.0029 16.4 0.0 1 8.0 0.0 2.2 2 0 0 2 2 2 2 Alphaherpesvirus glycoprotein E Ig_2 PF13895.6 PIK57883.1 - 0.0029 17.9 1.1 0.53 10.7 0.0 3.7 3 1 1 4 4 4 1 Immunoglobulin domain DUF2207 PF09972.9 PIK57883.1 - 0.0044 15.9 0.0 0.008 15.0 0.0 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) CD34_antigen PF06365.12 PIK57883.1 - 0.013 15.1 0.3 0.028 14.0 0.3 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF3377 PF11857.8 PIK57883.1 - 0.036 14.0 0.1 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF4448 PF14610.6 PIK57883.1 - 0.039 13.7 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) C2-set_2 PF08205.12 PIK57883.1 - 0.043 13.9 3.6 0.93 9.6 0.1 3.2 2 1 1 3 3 3 0 CD80-like C2-set immunoglobulin domain RIFIN PF02009.16 PIK57883.1 - 0.047 13.6 0.3 0.085 12.7 0.3 1.4 1 0 0 1 1 1 0 Rifin Shisa PF13908.6 PIK57883.1 - 0.079 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator AAA_22 PF13401.6 PIK57883.1 - 0.11 12.8 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ig PF00047.25 PIK57883.1 - 0.32 11.2 5.0 52 4.1 0.0 4.8 4 2 0 5 5 5 0 Immunoglobulin domain C1-set PF07654.15 PIK57883.1 - 0.54 10.7 3.6 6.4 7.2 0.1 3.2 3 1 0 3 3 2 0 Immunoglobulin C1-set domain Marek_A PF02124.15 PIK57883.1 - 1.3 8.8 6.6 8.1 6.2 3.1 2.9 2 1 0 2 2 2 0 Marek's disease glycoprotein A 2-Hacid_dh_C PF02826.19 PIK57885.1 - 1.6e-11 43.9 0.0 2.5e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 PIK57885.1 - 0.092 12.4 0.0 0.22 11.2 0.0 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Pyr_redox PF00070.27 PIK57885.1 - 0.1 13.2 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 PIK57885.1 - 0.16 11.3 0.0 0.7 9.2 0.0 1.9 2 0 0 2 2 2 0 ThiF family Pyr_redox_2 PF07992.14 PIK57885.1 - 0.17 11.1 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAGK_acc PF00609.19 PIK57886.1 - 1.9e-51 174.5 0.0 2.7e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 PIK57886.1 - 4.6e-21 74.7 0.0 8.6e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_2 PF12796.7 PIK57887.1 - 2.8e-08 34.2 0.1 0.018 15.6 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK57887.1 - 1.3e-05 25.6 0.0 0.083 13.5 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK57887.1 - 2.2e-05 24.4 0.0 4.5 8.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK57887.1 - 0.019 15.3 0.0 43 4.6 0.0 3.7 3 1 1 4 4 4 0 Ankyrin repeats (many copies) DUF3921 PF13060.6 PIK57887.1 - 0.12 12.4 0.6 0.33 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) Sgf11 PF08209.11 PIK57888.1 - 1.4e-13 50.2 4.9 2.3e-13 49.4 4.9 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SCA7 PF08313.12 PIK57888.1 - 2.6e-05 24.0 1.2 5.8e-05 22.9 1.2 1.5 1 0 0 1 1 1 1 SCA7, zinc-binding domain DUF4703 PF15775.5 PIK57889.1 - 0.42 10.4 2.6 17 5.2 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4703) Proteasome_A_N PF10584.9 PIK57889.1 - 1.5 8.6 4.2 27 4.5 0.3 2.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature PRRSV_2b PF07069.11 PIK57890.1 - 0.11 13.1 0.3 0.15 12.6 0.3 1.2 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b tRNA-synt_2 PF00152.20 PIK57892.1 - 1e-78 264.6 0.1 1.2e-78 264.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 PIK57892.1 - 7.7e-05 22.3 0.1 0.11 12.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 PIK57893.1 - 0.084 12.9 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain OAD_gamma PF04277.13 PIK57893.1 - 0.4 11.3 3.5 0.58 10.8 3.5 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Na_Pi_cotrans PF02690.15 PIK57894.1 - 2.9e-40 137.6 19.9 3.8e-25 88.6 7.6 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter TMEM232 PF15877.5 PIK57895.1 - 2.2e-64 218.1 0.5 6.2e-47 160.6 0.0 3.9 2 2 1 3 3 3 3 Transmembrane protein family 232 OmpH PF03938.14 PIK57895.1 - 3 8.2 13.1 6.9 7.0 13.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 PIK57896.1 - 0.065 13.5 17.7 0.082 13.1 17.7 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Asp-B-Hydro_N PF05279.11 PIK57896.1 - 0.62 10.1 20.8 0.76 9.8 20.8 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4776 PF16003.5 PIK57896.1 - 2.2 7.2 14.5 2.6 7.0 14.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF2151 PF10221.9 PIK57896.1 - 4.3 5.8 13.9 5.2 5.5 13.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator V_ATPase_I PF01496.19 PIK57896.1 - 5.9 4.7 10.6 6.9 4.5 10.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 PIK57896.1 - 6.2 5.6 22.9 7.9 5.3 22.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RhoGAP PF00620.27 PIK57897.1 - 1.1e-42 145.5 0.6 4.2e-42 143.5 0.0 2.3 3 0 0 3 3 3 1 RhoGAP domain G10 PF01125.17 PIK57897.1 - 0.23 11.2 0.1 0.23 11.2 0.1 2.9 3 1 0 3 3 3 0 G10 protein Spot_14 PF07084.12 PIK57897.1 - 1.7 8.8 10.0 1 9.5 3.1 2.7 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 RUN PF02759.19 PIK57900.1 - 1.6e-13 50.8 0.0 3.7e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 RUN domain SH3_2 PF07653.17 PIK57900.1 - 1.8e-06 27.5 0.0 3.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK57900.1 - 9.6e-06 25.4 0.0 1.7e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK57900.1 - 0.00032 20.3 0.1 0.00093 18.8 0.0 1.8 2 0 0 2 2 2 1 SH3 domain EGF_CA PF07645.15 PIK57901.1 - 4.5e-93 305.2 275.6 1.2e-09 38.2 8.5 19.1 18 1 1 19 19 19 14 Calcium-binding EGF domain EGF_3 PF12947.7 PIK57901.1 - 1.5e-62 207.5 251.3 8.4e-10 38.7 9.1 19.5 19 2 0 19 19 19 15 EGF domain EGF PF00008.27 PIK57901.1 - 9.2e-35 118.6 269.6 0.00016 21.9 4.7 21.4 20 2 0 20 20 20 17 EGF-like domain cEGF PF12662.7 PIK57901.1 - 5.7e-28 96.5 203.0 4e-08 33.0 3.1 20.9 21 1 0 21 21 21 13 Complement Clr-like EGF-like hEGF PF12661.7 PIK57901.1 - 2.6e-15 56.4 211.5 0.0044 17.6 5.4 22.2 20 2 0 20 20 20 14 Human growth factor-like EGF NIDO PF06119.14 PIK57901.1 - 5.6e-14 52.9 0.0 1.1e-13 51.9 0.0 1.5 1 0 0 1 1 1 1 Nidogen-like EGF_MSP1_1 PF12946.7 PIK57901.1 - 7.5e-09 35.5 211.8 0.00046 20.2 4.9 17.5 18 0 0 18 18 18 12 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK57901.1 - 8.8e-09 35.5 166.5 0.029 14.7 9.5 15.5 13 1 1 14 14 14 12 Pvs28 EGF domain FXa_inhibition PF14670.6 PIK57901.1 - 1.1e-06 28.8 5.0 1.1e-06 28.8 5.0 20.7 16 4 4 20 20 20 10 Coagulation Factor Xa inhibitory site LysM PF01476.20 PIK57902.1 - 8.8e-09 35.3 0.1 1.4e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 LysM domain TMEM154 PF15102.6 PIK57903.1 - 0.0019 18.1 0.1 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 TMEM154 protein family EphA2_TM PF14575.6 PIK57903.1 - 0.015 16.2 0.0 0.059 14.3 0.0 2.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 PIK57903.1 - 0.016 15.0 4.9 0.033 13.9 4.9 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Baculo_11_kDa PF06143.11 PIK57903.1 - 0.049 13.2 0.2 0.14 11.8 0.2 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family MLANA PF14991.6 PIK57903.1 - 0.098 12.9 0.1 0.91 9.8 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A PRIMA1 PF16101.5 PIK57903.1 - 0.29 11.2 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Syndecan PF01034.20 PIK57903.1 - 3.3 7.7 4.4 9.4 6.2 4.5 1.7 1 1 0 1 1 1 0 Syndecan domain MYEOV2 PF15004.6 PIK57904.1 - 1.3e-13 51.2 1.6 9.4 6.8 0.0 9.7 1 1 11 13 13 13 3 Myeloma-overexpressed-like DUF268 PF03269.14 PIK57904.1 - 1.7e-09 37.8 0.8 37 4.1 0.0 7.7 1 1 8 10 10 10 0 Caenorhabditis protein of unknown function, DUF268 Adeno_E4_ORF3 PF06931.11 PIK57904.1 - 3.3e-05 24.1 0.0 1.1e+02 3.1 0.0 6.9 1 1 9 10 10 10 0 Mastadenovirus E4 ORF3 protein DUF4573 PF15140.6 PIK57904.1 - 0.0033 17.2 11.7 0.46 10.3 3.6 3.5 1 1 2 3 3 3 3 Domain of unknown function (DUF4573) DUF4813 PF16072.5 PIK57904.1 - 6.2 6.4 20.5 17 4.9 0.3 5.0 1 1 5 6 6 6 0 Domain of unknown function (DUF4813) fn3 PF00041.21 PIK57905.1 - 1.1e-47 160.2 11.4 1.5e-12 47.7 0.1 5.9 6 0 0 6 6 6 5 Fibronectin type III domain Ig_3 PF13927.6 PIK57905.1 - 2.8e-21 75.9 0.0 4.1e-11 43.3 0.0 4.3 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK57905.1 - 4.9e-17 61.8 0.0 2.5e-10 40.3 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK57905.1 - 2.8e-12 46.6 3.1 0.00021 21.4 0.0 4.7 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.6 PIK57905.1 - 3.8e-10 39.9 0.0 3.1e-05 24.2 0.0 3.9 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK57905.1 - 1.2e-09 38.3 5.8 0.42 10.8 0.0 6.3 4 2 2 6 6 6 3 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 PIK57905.1 - 4.3e-08 33.6 8.6 2e-05 25.0 0.2 5.8 6 1 0 6 6 6 1 Purple acid Phosphatase, N-terminal domain Ig_6 PF18452.1 PIK57905.1 - 0.00022 20.7 0.0 4.4 7.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C2-set PF05790.15 PIK57905.1 - 0.013 15.7 0.0 8.9 6.6 0.0 2.8 2 0 0 2 2 2 0 Immunoglobulin C2-set domain FAST_2 PF08368.12 PIK57906.1 - 1.9e-24 86.2 0.6 2.3e-23 82.8 0.0 3.1 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 PIK57906.1 - 4.5e-17 61.8 4.7 1.2e-12 47.6 0.2 5.2 5 1 0 5 5 5 2 FAST kinase-like protein, subdomain 1 RAP PF08373.10 PIK57906.1 - 1.9e-14 53.5 1.8 5.5e-14 52.0 0.2 2.6 2 0 0 2 2 2 1 RAP domain NUC130_3NT PF08158.12 PIK57906.1 - 0.22 11.9 5.3 0.71 10.2 0.1 3.5 4 0 0 4 4 4 0 NUC130/3NT domain APC_N_CC PF16689.5 PIK57907.1 - 3.1e-18 65.6 4.6 1e-17 63.9 4.6 1.9 1 0 0 1 1 1 1 Coiled-coil N-terminus of APC, dimerisation domain Suppressor_APC PF11414.8 PIK57907.1 - 5.1e-08 32.9 7.3 5.1e-08 32.9 7.3 2.8 3 1 0 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein HALZ PF02183.18 PIK57907.1 - 0.0034 17.6 0.7 0.0034 17.6 0.7 2.5 2 1 0 2 2 2 1 Homeobox associated leucine zipper JIP_LZII PF16471.5 PIK57907.1 - 0.0077 16.4 0.8 0.0077 16.4 0.8 2.9 4 0 0 4 4 4 1 JNK-interacting protein leucine zipper II Phage_integr_3 PF16795.5 PIK57907.1 - 0.054 13.4 0.3 0.11 12.4 0.2 1.5 1 1 0 1 1 1 0 Archaeal phage integrase YabA PF06156.13 PIK57907.1 - 2 9.1 15.0 0.72 10.5 0.8 3.2 2 1 1 3 3 3 0 Initiation control protein YabA APC_rep PF18797.1 PIK57908.1 - 4.5e-09 37.1 0.1 1.3e-08 35.6 0.1 1.9 1 0 0 1 1 1 1 Adenomatous polyposis coli (APC) repeat Arm PF00514.23 PIK57908.1 - 0.053 13.6 1.0 0.22 11.6 0.0 2.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Arm PF00514.23 PIK57909.1 - 7.6e-10 38.5 0.2 0.0023 17.9 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat MBD PF01429.19 PIK57910.1 - 0.022 14.5 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Methyl-CpG binding domain PWWP PF00855.17 PIK57912.1 - 2.2e-15 56.9 0.0 6.3e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 PWWP domain MTBP_C PF14920.6 PIK57912.1 - 2.7 7.7 10.1 0.42 10.3 2.3 2.2 2 0 0 2 2 2 0 MDM2-binding ALMT PF11744.8 PIK57912.1 - 9.5 4.9 6.9 0.41 9.4 1.1 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter RCR PF12273.8 PIK57914.1 - 0.012 16.2 4.7 0.89 10.2 4.7 2.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Corona_NS4 PF03905.13 PIK57914.1 - 0.62 10.1 4.1 0.46 10.5 1.8 2.0 2 0 0 2 2 2 0 Coronavirus non-structural protein NS4 DUF5305 PF17231.2 PIK57915.1 - 0.003 17.0 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) SARAF PF06682.12 PIK57915.1 - 0.0036 17.0 0.1 0.0048 16.6 0.1 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 PIK57915.1 - 0.012 16.4 0.1 0.032 15.1 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 PIK57915.1 - 0.075 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Orf78 PF06024.12 PIK57915.1 - 0.13 12.6 0.3 0.32 11.3 0.3 1.7 1 1 0 1 1 1 0 Orf78 (ac78) Ureide_permease PF07168.11 PIK57915.1 - 0.26 10.0 0.2 0.37 9.5 0.2 1.1 1 0 0 1 1 1 0 Ureide permease MFS_1 PF07690.16 PIK57917.1 - 6.6e-27 94.4 18.7 6.6e-27 94.4 18.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CdiA_C_tRNase PF18664.1 PIK57917.1 - 0.0083 16.3 0.2 0.34 11.1 0.0 2.8 2 1 1 3 3 3 1 CdiA C-terminal tRNase domain NuA4 PF09340.10 PIK57917.1 - 0.02 14.7 1.4 36 4.3 0.0 3.6 3 1 0 3 3 3 0 Histone acetyltransferase subunit NuA4 zf-H2C2_5 PF13909.6 PIK57917.1 - 1.1 9.1 10.5 28 4.6 0.2 4.4 4 0 0 4 4 4 0 C2H2-type zinc-finger domain PAD_N PF08526.10 PIK57917.1 - 1.5 9.2 6.0 20 5.6 0.1 3.4 2 1 2 4 4 4 0 Protein-arginine deiminase (PAD) N-terminal domain Reprolysin_2 PF13574.6 PIK57918.1 - 2e-36 125.7 0.5 3.4e-36 125.0 0.5 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK57918.1 - 2.1e-34 119.4 0.9 4.8e-34 118.2 0.9 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK57918.1 - 4e-19 69.3 0.3 1e-18 68.0 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK57918.1 - 7e-15 55.2 0.7 1.3e-14 54.4 0.7 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 PIK57918.1 - 0.0002 21.3 0.0 0.0002 21.3 0.0 3.0 3 1 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Disintegrin PF00200.23 PIK57918.1 - 0.0014 19.4 22.8 0.0014 19.4 22.8 3.1 2 1 1 3 3 3 1 Disintegrin ODV-E18 PF10717.9 PIK57918.1 - 0.04 13.8 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 UPF0370 PF13980.6 PIK57918.1 - 0.2 11.7 4.8 0.46 10.6 4.8 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) SBF PF01758.16 PIK57919.1 - 0.0022 17.7 3.0 0.0022 17.7 3.0 2.0 1 1 1 2 2 2 1 Sodium Bile acid symporter family DUF1385 PF07136.11 PIK57919.1 - 3.2 7.0 10.4 0.66 9.2 3.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1385) Nrap_D5 PF17406.2 PIK57920.1 - 0.11 12.2 1.7 8.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 Skp1 PF01466.19 PIK57920.1 - 1 9.5 5.3 1.6 8.9 0.0 3.6 3 0 0 3 3 3 0 Skp1 family, dimerisation domain Laminin_EGF PF00053.24 PIK57921.1 - 0.00016 21.8 115.4 0.009 16.1 19.6 8.0 1 1 7 8 8 8 3 Laminin EGF domain EGF_2 PF07974.13 PIK57921.1 - 0.0051 17.1 109.0 0.0068 16.7 7.9 8.3 7 1 0 7 7 7 5 EGF-like domain hEGF PF12661.7 PIK57921.1 - 0.0096 16.5 3.5 0.0096 16.5 3.5 8.3 7 2 1 8 8 8 4 Human growth factor-like EGF RRM_1 PF00076.22 PIK57922.1 - 7.5e-16 57.7 0.0 1.6e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 PIK57922.1 - 8.4e-08 31.8 0.3 2.6e-07 30.3 0.3 1.8 2 0 0 2 2 2 1 SAP domain RRM_5 PF13893.6 PIK57922.1 - 4.7e-05 23.0 0.0 9.1e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Leo1 PF04004.13 PIK57923.1 - 3.3e-49 166.9 0.0 3.3e-49 166.9 0.0 2.9 2 1 0 2 2 2 1 Leo1-like protein GABP-alpha PF11620.8 PIK57927.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 GA-binding protein alpha chain SH2 PF00017.24 PIK57928.1 - 6.1e-24 83.9 0.3 2.3e-12 46.8 0.1 2.2 2 0 0 2 2 2 2 SH2 domain Cu-oxidase_2 PF07731.14 PIK57928.1 - 0.022 14.5 0.0 7.1 6.4 0.0 2.3 2 0 0 2 2 2 0 Multicopper oxidase HMG_box_5 PF14887.6 PIK57928.1 - 0.18 11.8 0.0 21 5.2 0.0 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Pkinase_Tyr PF07714.17 PIK57929.1 - 1.5e-31 109.6 0.0 1.9e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK57929.1 - 2.5e-18 66.4 0.0 3e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Hemopexin PF00045.19 PIK57930.1 - 8.9e-52 172.8 14.3 3.3e-18 65.4 0.8 4.2 4 0 0 4 4 4 4 Hemopexin DUF4993 PF16384.5 PIK57930.1 - 0.089 11.8 2.8 0.83 8.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function Hemopexin PF00045.19 PIK57931.1 - 2.3e-93 306.0 25.7 1.4e-18 66.5 0.8 8.3 8 0 0 8 8 8 8 Hemopexin F-box-like PF12937.7 PIK57932.1 - 8e-11 41.7 6.0 2e-07 30.8 3.0 2.8 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 PIK57932.1 - 4.1e-08 32.9 8.1 1e-05 25.2 4.4 3.7 3 1 0 3 3 3 1 F-box domain TPR_2 PF07719.17 PIK57932.1 - 0.0012 18.8 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 PIK57932.1 - 0.0054 16.8 0.0 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pepdidase_M14_N PF18027.1 PIK57933.1 - 2.7e-17 63.1 0.1 1.1e-16 61.1 0.1 2.1 2 0 0 2 2 2 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 PIK57933.1 - 2.6e-15 57.0 0.2 8.2e-15 55.4 0.0 1.9 2 0 0 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.14 PIK57933.1 - 0.0003 19.9 0.0 0.0013 17.9 0.0 1.9 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family zf-HIT PF04438.16 PIK57935.1 - 2.2 8.2 14.3 2.3 8.2 3.0 3.4 3 0 0 3 3 3 0 HIT zinc finger Joubert PF15392.6 PIK57935.1 - 9 5.9 15.7 13 5.4 15.7 1.2 1 0 0 1 1 1 0 Joubert syndrome-associated PAS_11 PF14598.6 PIK57936.1 - 1.7e-13 50.7 0.1 9.7e-10 38.6 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 PIK57936.1 - 2.4e-07 30.8 1.3 7.6e-06 25.9 0.0 3.3 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 PIK57936.1 - 0.00015 22.0 0.1 0.043 14.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK57936.1 - 0.00022 21.4 0.1 0.0012 19.1 0.1 2.3 2 0 0 2 2 2 1 PAS domain CBP_BcsS PF17036.5 PIK57936.1 - 0.13 12.2 0.5 0.24 11.3 0.5 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsS LMBR1 PF04791.16 PIK57937.1 - 0.15 10.9 1.9 0.2 10.5 1.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein WDCP PF15390.6 PIK57937.1 - 0.23 9.8 5.6 0.33 9.3 5.6 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family TERB2 PF15101.6 PIK57937.1 - 6.4 6.8 15.6 2.1 8.4 12.6 1.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Itfg2 PF15907.5 PIK57937.1 - 6.7 5.7 8.6 9.5 5.2 8.6 1.2 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 DUF1126 PF06565.12 PIK57939.1 - 4e-26 90.9 0.0 7.4e-26 90.0 0.0 1.5 1 0 0 1 1 1 1 DUF1126 PH-like domain EF-hand_7 PF13499.6 PIK57939.1 - 7e-09 36.0 0.3 1.5e-08 34.9 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK57939.1 - 2e-07 30.1 0.9 3.8e-05 22.9 0.0 3.3 3 1 1 4 4 4 1 EF hand EF-hand_6 PF13405.6 PIK57939.1 - 7e-07 28.7 3.6 1.1e-05 24.9 0.0 3.4 3 1 1 4 4 4 1 EF-hand domain DUF5580 PF17743.1 PIK57939.1 - 3.5e-06 25.8 0.0 4.2e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_5 PF13202.6 PIK57939.1 - 1.4e-05 24.3 0.4 0.0002 20.7 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_11 PF08976.11 PIK57939.1 - 0.00058 20.7 0.0 0.00089 20.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 PIK57939.1 - 0.0022 17.8 0.2 0.088 12.7 0.1 2.9 1 1 2 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK57939.1 - 0.024 14.9 0.0 0.038 14.3 0.0 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 PIK57939.1 - 0.14 12.1 0.1 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 EF hand DUF1126 PF06565.12 PIK57940.1 - 1.5e-70 233.6 1.3 4.3e-37 126.2 0.2 2.2 2 0 0 2 2 2 2 DUF1126 PH-like domain Pkinase PF00069.25 PIK57942.1 - 1.5e-38 132.7 0.1 1.9e-38 132.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57942.1 - 1.3e-12 47.6 0.0 3.7e-12 46.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 PIK57942.1 - 0.03 13.9 0.3 0.11 12.1 0.0 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 PIK57942.1 - 0.11 11.8 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Archease PF01951.16 PIK57943.1 - 4.2e-31 108.0 0.1 5e-31 107.8 0.1 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) SAP130_C PF16014.5 PIK57944.1 - 0.02 14.0 1.4 0.024 13.8 1.4 1.0 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Archease PF01951.16 PIK57944.1 - 0.034 14.4 0.1 0.034 14.4 0.1 1.6 2 0 0 2 2 2 0 Archease protein family (MTH1598/TM1083) DUF2477 PF10631.9 PIK57944.1 - 0.12 13.1 0.0 0.14 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Merozoite_SPAM PF07133.11 PIK57944.1 - 0.44 10.5 12.9 0.66 10.0 12.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) TRAP_alpha PF03896.16 PIK57944.1 - 0.66 9.1 3.5 0.61 9.2 3.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Ank_5 PF13857.6 PIK57945.1 - 4.8e-27 93.7 6.1 1.8e-10 40.8 0.2 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK57945.1 - 3e-26 91.4 4.7 1.6e-15 57.2 0.1 4.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK57945.1 - 2e-22 76.9 0.2 1.2e-06 28.4 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 PIK57945.1 - 2.5e-22 78.3 1.8 7.1e-09 35.7 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 PIK57945.1 - 1.3e-21 77.0 0.1 4.3e-14 52.9 0.0 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) MtrF PF09472.10 PIK57945.1 - 0.028 13.8 0.1 0.05 13.0 0.1 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Oxysterol_BP PF01237.18 PIK57946.1 - 5.2e-93 311.8 0.0 1e-92 310.9 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein Mating_N PF12731.7 PIK57946.1 - 0.031 14.4 0.6 0.11 12.6 0.6 1.9 1 0 0 1 1 1 0 Mating-type protein beta 1 DUF3323 PF11796.8 PIK57946.1 - 0.049 13.5 0.8 0.75 9.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) CENP-F_leu_zip PF10473.9 PIK57946.1 - 0.81 9.7 10.7 0.086 12.9 5.6 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 PIK57946.1 - 0.86 7.7 5.6 0.67 8.1 0.1 2.7 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA GAS PF13851.6 PIK57946.1 - 7.3 5.9 10.5 1.7 8.0 1.6 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Oxysterol_BP PF01237.18 PIK57947.1 - 4.3e-37 127.8 4.0 4.7e-37 127.7 4.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein TUDOR PF00567.24 PIK57948.1 - 1.2e-17 64.1 0.0 4.2e-17 62.3 0.0 1.9 2 0 0 2 2 2 1 Tudor domain OST-HTH PF12872.7 PIK57948.1 - 6.5e-07 29.1 0.0 0.0033 17.2 0.0 2.4 2 0 0 2 2 2 2 OST-HTH/LOTUS domain Adaptin_binding PF10199.9 PIK57948.1 - 0.12 13.0 0.5 0.28 11.8 0.5 1.7 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Patched PF02460.18 PIK57949.1 - 9.7e-78 262.1 24.6 1.7e-47 162.1 2.4 2.2 2 0 0 2 2 2 2 Patched family NPC1_N PF16414.5 PIK57949.1 - 7.9e-70 235.2 7.6 1.6e-69 234.2 7.6 1.5 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 PIK57949.1 - 6.6e-52 175.4 5.5 6.6e-52 175.4 5.5 2.8 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 PIK57949.1 - 1.5e-05 24.1 6.4 1.5e-05 24.1 6.4 2.1 3 1 0 3 3 3 1 MMPL family ACR_tran PF00873.19 PIK57949.1 - 4.6 4.7 11.4 0.11 10.2 4.7 1.5 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Fz PF01392.22 PIK57950.1 - 6e-17 62.3 14.3 6.3e-09 36.4 4.0 2.5 2 1 0 2 2 2 2 Fz domain Fz PF01392.22 PIK57951.1 - 3.2e-17 63.2 31.5 0.015 15.9 0.6 6.7 6 0 0 6 6 6 6 Fz domain CotJA PF11007.8 PIK57951.1 - 0.045 13.6 0.0 2e+02 1.9 0.0 4.3 4 0 0 4 4 4 0 Spore coat associated protein JA (CotJA) zf-A20 PF01754.16 PIK57951.1 - 0.051 13.5 0.6 1.7e+02 2.3 0.0 4.5 4 0 0 4 4 4 0 A20-like zinc finger Fz PF01392.22 PIK57952.1 - 1.3e-19 70.8 14.2 8.3e-11 42.5 2.3 2.6 2 1 0 2 2 2 2 Fz domain CUB PF00431.20 PIK57952.1 - 4.6e-12 46.2 0.0 7.2e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 PIK57952.1 - 2.8e-08 33.8 8.0 2.8e-08 33.8 8.0 2.5 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Trypsin PF00089.26 PIK57953.1 - 2.4e-33 115.8 0.0 2.9e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK57953.1 - 0.0069 16.8 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF2452 PF10504.9 PIK57954.1 - 8.4e-69 230.0 0.0 1.1e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) DUF2721 PF11026.8 PIK57954.1 - 0.046 13.6 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) 7tm_1 PF00001.21 PIK57956.1 - 5.1e-39 134.2 2.1 5.7e-39 134.0 2.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK57956.1 - 2.2e-10 40.4 5.6 3.1e-10 39.9 5.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK57956.1 - 4.3e-07 29.8 11.2 4.3e-07 29.8 11.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK57956.1 - 0.00025 20.9 6.0 0.00039 20.3 6.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 PIK57956.1 - 0.002 17.7 9.9 0.0033 17.0 9.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc UPF0542 PF15086.6 PIK57956.1 - 0.094 12.7 0.2 0.54 10.2 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Viral_Beta_CD PF04530.12 PIK57956.1 - 0.1 12.9 0.2 0.24 11.7 0.2 1.6 1 0 0 1 1 1 0 Viral Beta C/D like family SHR3_chaperone PF08229.11 PIK57956.1 - 0.5 9.3 4.2 6.3 5.7 4.2 2.2 1 1 0 1 1 1 0 ER membrane protein SH3 Plexin_cytopl PF08337.12 PIK57957.1 - 1.6e-101 340.7 0.3 2e-101 340.4 0.3 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Plexin_cytopl PF08337.12 PIK57958.1 - 8.6e-67 226.0 3.0 1e-66 225.8 3.0 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 PIK57959.1 - 6.1e-29 101.1 1.2 7.4e-29 100.8 0.0 1.6 2 0 0 2 2 2 1 Sema domain PSI PF01437.25 PIK57959.1 - 5.1e-11 42.9 34.8 1.5e-06 28.7 13.7 2.6 2 0 0 2 2 2 2 Plexin repeat TIG_plexin PF17960.1 PIK57959.1 - 5.3e-10 39.2 0.3 5.3e-10 39.2 0.3 2.1 2 0 0 2 2 2 1 TIG domain MGC-24 PF05283.11 PIK57959.1 - 0.025 15.0 5.3 0.025 15.0 5.3 3.0 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PSI_integrin PF17205.3 PIK57959.1 - 0.042 13.6 29.6 0.45 10.3 11.8 2.7 2 0 0 2 2 2 0 Integrin plexin domain TIG_2 PF18020.1 PIK57959.1 - 0.089 13.4 0.1 30 5.3 0.0 2.6 2 0 0 2 2 2 0 TIG domain found in plexin CGI-121 PF08617.10 PIK57960.1 - 4.1e-38 131.1 2.6 4.7e-38 130.9 2.6 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Pkinase PF00069.25 PIK57962.1 - 1e-35 123.4 0.0 1.6e-35 122.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK57962.1 - 7.8e-34 117.1 0.0 1.2e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Death PF00531.22 PIK57962.1 - 0.00094 19.3 0.0 0.0022 18.1 0.0 1.7 1 0 0 1 1 1 1 Death domain APH PF01636.23 PIK57962.1 - 0.084 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Methyltransf_25 PF13649.6 PIK57963.1 - 6.5e-08 33.2 0.0 1.6e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 PIK57963.1 - 9e-08 31.8 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 PIK57963.1 - 9.4e-08 32.0 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmC_N PF17827.1 PIK57963.1 - 5.1e-07 30.2 0.0 1.6e-06 28.6 0.0 1.9 1 1 0 1 1 1 1 PrmC N-terminal domain PrmA PF06325.13 PIK57963.1 - 1.5e-05 24.5 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 PIK57963.1 - 0.00015 21.5 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 PIK57963.1 - 0.00021 21.3 0.1 0.00032 20.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK57963.1 - 0.00023 21.9 0.0 0.00045 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK57963.1 - 0.00055 20.5 0.0 0.0013 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK57963.1 - 0.0016 18.3 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 PIK57963.1 - 0.0032 16.6 0.0 0.0057 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_16 PF10294.9 PIK57963.1 - 0.0054 16.5 0.0 0.0097 15.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_28 PF02636.17 PIK57963.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 PIK57963.1 - 0.021 14.6 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 PIK57963.1 - 0.022 14.7 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 PIK57963.1 - 0.035 13.4 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 PIK57963.1 - 0.036 13.9 0.0 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Hypothetical methyltransferase tRNA_U5-meth_tr PF05958.11 PIK57963.1 - 0.092 11.7 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_4 PF02390.17 PIK57963.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase AviRa PF11599.8 PIK57963.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa WIF PF02019.18 PIK57964.1 - 4.5e-14 52.3 0.0 6.9e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 WIF domain EGF_2 PF07974.13 PIK57964.1 - 5.4e-12 45.9 56.5 0.00025 21.3 12.0 3.5 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.27 PIK57964.1 - 5e-07 29.9 48.2 0.00087 19.5 12.3 3.6 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK57964.1 - 0.00056 20.4 44.2 0.012 16.2 5.6 4.4 4 0 0 4 4 4 2 Human growth factor-like EGF DSL PF01414.19 PIK57964.1 - 0.0084 16.4 12.2 0.0084 16.4 12.2 3.4 2 1 1 3 3 3 2 Delta serrate ligand Laminin_EGF PF00053.24 PIK57964.1 - 3.3 7.9 38.3 2.6 8.3 10.2 3.3 1 1 2 3 3 3 0 Laminin EGF domain Pyr_redox_2 PF07992.14 PIK57965.1 - 2.7e-55 187.7 3.0 4.4e-53 180.4 1.5 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 PIK57965.1 - 9.9e-40 135.2 1.7 1e-39 135.2 0.1 1.9 3 0 0 3 3 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 PIK57965.1 - 1.8e-10 41.2 4.0 5.8e-07 30.0 0.3 3.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 PIK57965.1 - 1.8e-09 37.4 0.1 1.8e-09 37.4 0.1 2.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK57965.1 - 1.4e-08 34.2 2.3 1.8e-08 33.9 0.8 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 PIK57965.1 - 7.2e-08 31.9 2.9 2.6e-07 30.1 0.5 2.6 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 PIK57965.1 - 1.7e-06 28.1 3.2 0.00022 21.4 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 PIK57965.1 - 0.0001 21.7 2.8 0.099 11.9 0.6 3.2 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 PIK57965.1 - 0.00027 20.3 2.5 0.23 10.7 0.2 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 PIK57965.1 - 0.00085 18.1 0.5 0.00085 18.1 0.5 2.6 4 0 0 4 4 4 1 HI0933-like protein Thi4 PF01946.17 PIK57965.1 - 0.00091 18.5 0.8 0.0023 17.2 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 PIK57965.1 - 0.0087 15.3 2.9 0.035 13.3 0.3 2.3 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 PIK57965.1 - 0.013 14.6 2.8 1.7 7.6 0.4 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 PIK57965.1 - 0.025 13.9 2.7 5.6 6.3 0.1 3.3 3 1 1 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 PIK57965.1 - 0.054 13.1 0.7 8.2 6.0 0.2 2.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Clathrin_propel PF01394.20 PIK57965.1 - 0.095 13.1 0.0 38 4.8 0.0 3.0 3 0 0 3 3 2 0 Clathrin propeller repeat UPF0227 PF05728.12 PIK57965.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DAO PF01266.24 PIK57965.1 - 1.6 8.3 7.8 2.2 7.8 0.1 2.8 2 1 1 3 3 3 0 FAD dependent oxidoreductase tRNA_Me_trans PF03054.16 PIK57966.1 - 1.6e-114 382.4 0.0 1e-113 379.8 0.0 1.8 1 1 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 PIK57966.1 - 3.5e-07 29.6 0.0 1.5e-05 24.3 0.0 2.5 3 0 0 3 3 3 1 NAD synthase ThiI PF02568.14 PIK57966.1 - 0.00011 21.9 0.0 0.00046 19.8 0.0 1.9 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 PIK57966.1 - 0.012 15.1 0.0 0.043 13.3 0.0 1.8 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Antimicrobial22 PF16047.5 PIK57966.1 - 0.18 11.7 0.1 0.39 10.6 0.1 1.5 1 0 0 1 1 1 0 Frog antimicrobial peptide Myotub-related PF06602.14 PIK57967.1 - 2.4e-05 23.4 0.1 8.4e-05 21.7 0.0 1.8 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 PIK57967.1 - 0.0011 19.1 0.1 0.0024 17.9 0.1 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family DHFR_2 PF06442.11 PIK57967.1 - 0.049 13.5 0.0 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 R67 dihydrofolate reductase Y_phosphatase2 PF03162.13 PIK57967.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 PIK57967.1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ank_2 PF12796.7 PIK57969.1 - 3.8e-22 78.7 0.0 9.5e-13 48.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK57969.1 - 2.3e-21 75.9 0.0 1.6e-12 47.6 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK57969.1 - 7e-19 67.7 0.1 7.8e-10 38.8 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK57969.1 - 5.4e-18 64.6 0.0 1.1e-05 25.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 PIK57969.1 - 1.7e-14 52.5 0.0 0.0058 17.0 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat SlyX PF04102.12 PIK57969.1 - 0.36 11.5 2.0 0.89 10.2 2.0 1.7 1 0 0 1 1 1 0 SlyX zf-met PF12874.7 PIK57970.1 - 3.5e-16 59.0 30.8 8.2e-06 26.0 1.7 5.4 5 0 0 5 5 5 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK57970.1 - 8.4e-11 41.9 28.7 0.0018 18.5 0.2 5.6 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK57970.1 - 1.5e-08 34.9 20.0 0.14 12.5 0.0 5.5 4 1 1 5 5 5 5 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 PIK57970.1 - 0.0011 18.6 2.4 0.091 12.4 0.1 2.7 2 0 0 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain Sugar_tr PF00083.24 PIK57971.1 - 1.9e-62 211.6 10.5 4.2e-45 154.5 0.7 2.3 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK57971.1 - 1.5e-09 37.2 0.3 1.5e-09 37.2 0.3 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily PSI_integrin PF17205.3 PIK57971.1 - 0.0096 15.6 6.5 0.02 14.6 6.5 1.5 1 0 0 1 1 1 1 Integrin plexin domain Peptidase_C48 PF02902.19 PIK57973.1 - 3.2e-07 30.4 0.4 7e-07 29.3 0.4 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PHD PF00628.29 PIK57973.1 - 2e-06 27.6 6.6 5.6e-06 26.2 6.6 1.8 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 PIK57973.1 - 0.076 13.1 0.9 0.076 13.1 0.9 2.5 1 1 1 2 2 2 0 PHD-finger Gin PF10764.9 PIK57973.1 - 0.27 11.2 3.5 0.65 10.0 3.5 1.7 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin CxC4 PF18717.1 PIK57974.1 - 4.5e-12 46.0 0.6 4.5e-12 46.0 0.6 3.0 3 0 0 3 3 3 1 CxC4 like cysteine cluster associated with KDZ transposases ROS_MUCR PF05443.11 PIK57974.1 - 0.013 15.6 3.1 0.04 14.0 0.3 2.6 3 0 0 3 3 3 0 ROS/MUCR transcriptional regulator protein TRAF6_Z2 PF18048.1 PIK57974.1 - 3.8 7.7 9.4 0.052 13.7 1.1 2.3 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 ABC_membrane_2 PF06472.15 PIK57975.1 - 5.2e-67 226.1 1.5 7.1e-67 225.6 1.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 PIK57976.1 - 9.2e-19 68.3 0.0 2.5e-18 66.9 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 PIK57976.1 - 0.0011 19.6 0.6 0.003 18.1 0.1 2.0 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 PIK57976.1 - 0.003 17.4 0.0 0.0053 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK57976.1 - 0.0038 16.7 0.1 0.13 11.6 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 PIK57976.1 - 0.0043 16.8 0.1 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 PIK57976.1 - 0.015 15.2 0.3 0.084 12.8 0.1 2.0 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 PIK57976.1 - 0.078 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 PIK57976.1 - 0.12 12.3 0.1 0.75 9.7 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK57976.1 - 0.15 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 PIK57976.1 - 0.2 11.0 0.0 0.37 10.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pyr_redox_2 PF07992.14 PIK57977.1 - 2.4e-44 151.8 0.0 3.2e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 PIK57977.1 - 2.8e-29 101.6 0.1 4.3e-29 101.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 PIK57977.1 - 3.1e-13 50.1 0.0 7e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK57977.1 - 2.8e-08 33.4 0.0 3.9e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SymE_toxin PF08845.10 PIK57977.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Toxin SymE, type I toxin-antitoxin system T2SSC PF11356.8 PIK57977.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system protein C CENP-P PF13096.6 PIK57978.1 - 2.1e-21 76.4 1.5 4.8e-21 75.3 0.2 2.1 2 0 0 2 2 2 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P Armet PF10208.9 PIK57979.1 - 2.7e-61 205.8 6.9 3.1e-61 205.5 6.9 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding HSP70 PF00012.20 PIK57980.1 - 1.2e-77 261.5 3.1 3.2e-76 256.8 1.5 2.6 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK57980.1 - 0.0019 17.1 0.1 1.5 7.6 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein SNF2_N PF00176.23 PIK57981.1 - 1.3e-37 129.3 0.0 2.3e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 PIK57981.1 - 9.5e-06 25.7 3.0 1.6e-05 25.0 0.0 2.9 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DUF5451 PF17532.2 PIK57981.1 - 0.023 15.0 1.4 0.052 13.8 1.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5451) Helicase_C PF00271.31 PIK57983.1 - 0.00055 20.3 0.0 0.001 19.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3464 PF11947.8 PIK57983.1 - 0.055 13.2 0.3 0.11 12.3 0.0 1.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 2OG-FeII_Oxy_3 PF13640.6 PIK57984.1 - 2.4e-15 57.2 0.3 5.4e-15 56.1 0.3 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SPARC_Ca_bdg PF10591.9 PIK57984.1 - 0.04 14.2 0.1 0.2 12.0 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region rve PF00665.26 PIK57985.1 - 2.4e-06 27.7 0.0 1.3e-05 25.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain HTH_8 PF02954.19 PIK57985.1 - 0.008 15.9 1.9 0.014 15.1 0.8 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_23 PF13384.6 PIK57985.1 - 3.1 7.7 6.1 0.72 9.7 0.8 2.7 2 0 0 2 2 2 0 Homeodomain-like domain 2OG-FeII_Oxy_3 PF13640.6 PIK57986.1 - 3e-05 24.8 1.9 0.00017 22.4 1.9 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_6 PF13405.6 PIK57986.1 - 0.0025 17.6 0.3 0.11 12.5 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 PIK57986.1 - 0.02 15.3 3.1 0.06 13.8 3.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 PIK57986.1 - 0.088 12.4 0.0 3.7 7.3 0.0 2.7 2 0 0 2 2 2 0 EF hand HEAT_2 PF13646.6 PIK57988.1 - 1.3e-27 96.0 0.2 1.3e-12 47.9 0.0 2.4 2 1 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 PIK57988.1 - 4e-23 79.7 0.1 0.00013 22.3 0.0 5.4 5 0 0 5 5 5 4 PBS lyase HEAT-like repeat HEAT PF02985.22 PIK57988.1 - 2.5e-10 39.7 0.3 0.082 13.2 0.0 5.8 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 PIK57988.1 - 1.4e-05 25.5 0.0 2.5 8.7 0.0 4.6 3 1 1 4 4 4 2 HEAT-like repeat Arm PF00514.23 PIK57988.1 - 0.0002 21.3 0.1 2.5 8.3 0.0 4.3 2 2 3 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 PIK57988.1 - 0.01 15.9 0.4 2.5 8.1 0.1 3.4 2 2 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 C9orf72-like PF15019.6 PIK57989.1 - 4.5e-53 180.3 3.6 6.5e-53 179.8 3.6 1.1 1 0 0 1 1 1 1 C9orf72-like protein family PKD_channel PF08016.12 PIK57990.1 - 9e-15 54.3 10.1 9e-15 54.3 10.1 1.9 3 0 0 3 3 3 1 Polycystin cation channel Ion_trans PF00520.31 PIK57990.1 - 6.2e-05 22.3 24.0 0.00055 19.2 24.1 2.0 1 1 0 1 1 1 1 Ion transport protein Phospholip_A2_1 PF00068.19 PIK57991.1 - 1.4e-25 89.9 5.9 2.3e-25 89.2 5.9 1.3 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.12 PIK57991.1 - 0.045 14.0 7.6 0.39 11.0 4.2 2.6 2 0 0 2 2 2 0 Phospholipase A2 Phospholip_A2_1 PF00068.19 PIK57992.1 - 6.4e-05 23.4 11.6 0.00014 22.3 11.6 1.6 1 1 0 1 1 1 1 Phospholipase A2 Phospholip_A2_1 PF00068.19 PIK57993.1 - 2.4e-26 92.4 12.0 3.2e-26 92.0 12.0 1.1 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.12 PIK57993.1 - 0.003 17.8 16.2 0.015 15.5 9.7 2.4 1 1 1 2 2 2 2 Phospholipase A2 Parvo_coat_N PF08398.10 PIK57993.1 - 0.096 12.9 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP1 SID-1_RNA_chan PF13965.6 PIK57994.1 - 0.0017 16.8 1.2 0.0027 16.2 1.2 1.3 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 TMEM154 PF15102.6 PIK57994.1 - 0.0042 17.0 6.3 0.0042 17.0 6.3 2.9 1 1 2 3 3 3 1 TMEM154 protein family Phospholamban PF04272.14 PIK57994.1 - 0.091 12.2 0.8 0.21 11.1 0.8 1.6 1 0 0 1 1 1 0 Phospholamban ABC2_membrane_3 PF12698.7 PIK57994.1 - 0.23 10.6 2.0 0.34 10.0 2.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein IL2RB_N1 PF18707.1 PIK57994.1 - 0.34 11.5 4.4 0.22 12.1 0.5 2.3 2 0 0 2 2 2 0 Interleukin-2 receptor subunit beta N-terminal domain 1 RIFIN PF02009.16 PIK57994.1 - 0.42 10.5 5.7 0.11 12.4 2.4 1.6 2 0 0 2 2 2 0 Rifin LRAT PF04970.13 PIK57995.1 - 2.5e-09 37.5 1.5 7.9e-08 32.7 0.8 2.8 2 1 0 2 2 2 1 Lecithin retinol acyltransferase MatE PF01554.18 PIK57995.1 - 0.059 13.0 0.0 0.086 12.5 0.0 1.1 1 0 0 1 1 1 0 MatE REC104 PF17378.2 PIK57996.1 - 0.0057 16.5 2.5 0.013 15.3 2.5 1.6 1 0 0 1 1 1 1 Meiotic recombination protein REC104 DUF829 PF05705.14 PIK57997.1 - 1e-34 120.5 0.3 1.2e-34 120.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Peptidase_S9 PF00326.21 PIK57997.1 - 1.5e-05 24.6 0.2 0.00026 20.5 0.2 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 PIK57997.1 - 0.0002 20.7 0.0 0.0054 16.0 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PI_PP_C PF18365.1 PIK57997.1 - 0.057 13.4 0.0 0.15 12.0 0.0 1.7 1 1 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain Abhydrolase_3 PF07859.13 PIK57997.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.8 PIK57997.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) MIF4G PF02854.19 PIK57998.1 - 8.3e-44 149.8 0.5 8.3e-44 149.8 0.5 2.4 3 0 0 3 3 3 1 MIF4G domain W2 PF02020.18 PIK57998.1 - 5.9e-18 64.8 0.3 2e-17 63.1 0.3 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.17 PIK57998.1 - 0.0005 20.0 4.9 0.0037 17.2 0.2 3.2 3 0 0 3 3 3 1 MA3 domain ALC PF17527.2 PIK57998.1 - 0.22 11.2 1.4 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Phage ALC protein Synaptobrevin PF00957.21 PIK57999.1 - 2.1e-12 46.6 0.1 5.1e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 Synaptobrevin YojJ PF10372.9 PIK57999.1 - 0.039 14.0 0.2 0.097 12.8 0.1 1.7 1 1 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Retrotrans_gag PF03732.17 PIK57999.1 - 0.43 10.9 3.4 0.35 11.2 1.1 2.1 3 1 0 3 3 3 0 Retrotransposon gag protein PIN_8 PF18476.1 PIK57999.1 - 0.95 9.3 8.3 0.32 10.8 4.9 1.8 2 0 0 2 2 2 0 PIN like domain OmpH PF03938.14 PIK57999.1 - 2.5 8.5 10.0 0.47 10.8 2.1 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SHIPPO-rpt PF07004.12 PIK58000.1 - 0.0006 20.6 2.5 0.21 12.5 0.3 3.4 3 0 0 3 3 3 2 Sperm-tail PG-rich repeat ECR1_N PF14382.6 PIK58000.1 - 0.058 13.2 0.8 0.49 10.2 0.2 2.5 2 1 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region BSD PF03909.17 PIK58001.1 - 3.4e-22 78.2 0.5 9.1e-16 57.6 0.0 2.7 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 PIK58001.1 - 1.1e-20 73.8 0.0 2.4e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain ApoL PF05461.11 PIK58001.1 - 5.7 6.2 6.9 3.1 7.0 0.2 2.7 3 0 0 3 3 3 0 Apolipoprotein L EF-hand_7 PF13499.6 PIK58002.1 - 7.1e-09 36.0 1.5 7.1e-09 36.0 1.5 4.0 3 2 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK58002.1 - 8.5e-08 31.5 2.1 0.00043 20.0 0.4 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK58002.1 - 1.2e-06 27.6 6.0 0.01 15.3 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 PIK58002.1 - 4.7e-05 23.2 2.8 0.13 12.2 0.0 4.0 3 0 0 3 3 3 2 EF-hand domain pair Peptidase_M3_N PF08439.10 PIK58002.1 - 0.002 18.3 2.5 0.002 18.3 2.5 4.4 4 1 1 5 5 5 1 Oligopeptidase F EF-hand_5 PF13202.6 PIK58002.1 - 0.0038 16.6 0.3 0.063 12.8 0.1 2.9 2 0 0 2 2 2 1 EF hand Pkinase PF00069.25 PIK58003.1 - 5.7e-20 71.8 0.0 8.2e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58003.1 - 5e-12 45.7 0.0 1.1e-11 44.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase SPATA6 PF14909.6 PIK58004.1 - 0.02 15.0 0.1 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 Spermatogenesis-assoc protein 6 Tetraspanin PF00335.20 PIK58005.1 - 6.8e-18 65.2 7.0 8.5e-18 64.9 7.0 1.1 1 0 0 1 1 1 1 Tetraspanin family YrvL PF14184.6 PIK58005.1 - 0.013 15.7 3.4 0.013 15.7 3.4 2.2 3 0 0 3 3 3 0 Regulatory protein YrvL CLN3 PF02487.17 PIK58006.1 - 5.9e-16 58.5 12.6 7e-16 58.3 12.6 1.2 1 0 0 1 1 1 1 CLN3 protein Orai-1 PF07856.12 PIK58006.1 - 6.3 6.5 9.9 2.8 7.6 3.5 2.2 2 0 0 2 2 2 0 Mediator of CRAC channel activity dDENN PF03455.19 PIK58008.1 - 1.2e-13 50.8 5.5 3.5e-13 49.3 5.5 1.9 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 PIK58008.1 - 1.3e-12 48.3 0.8 2.9e-12 47.2 0.8 1.6 1 0 0 1 1 1 1 uDENN domain DENN PF02141.21 PIK58008.1 - 2.1e-06 27.8 0.0 4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain GEMIN8 PF15348.6 PIK58008.1 - 0.084 13.2 10.9 0.37 11.1 0.0 2.4 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Ribosomal_L27A PF00828.19 PIK58009.1 - 2.2e-24 86.6 0.2 2.9e-24 86.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Bromo_MP PF01573.16 PIK58009.1 - 0.045 13.1 0.0 0.054 12.8 0.0 1.1 1 0 0 1 1 1 0 Bromovirus movement protein RTC4 PF14474.6 PIK58009.1 - 0.17 12.0 1.2 1.2 9.3 0.2 2.1 1 1 1 2 2 2 0 RTC4-like domain zf-B_box PF00643.24 PIK58010.1 - 1.8e-11 44.0 23.4 6.5e-08 32.6 6.8 4.5 5 0 0 5 5 5 2 B-box zinc finger zf-RING_UBOX PF13445.6 PIK58010.1 - 2.4e-07 30.7 2.8 2.4e-07 30.7 2.8 4.2 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK58010.1 - 3.6e-07 30.0 6.9 3.6e-07 30.0 6.9 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK58010.1 - 9.4e-07 28.7 7.8 9.4e-07 28.7 7.8 4.5 3 1 1 4 4 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK58010.1 - 7.7e-06 25.7 8.3 7.7e-06 25.7 8.3 4.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK58010.1 - 8.6e-06 25.5 6.5 8.6e-06 25.5 6.5 4.5 5 0 0 5 5 4 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK58010.1 - 1.1e-05 25.7 7.3 1.1e-05 25.7 7.3 3.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_4 PF14570.6 PIK58010.1 - 0.0014 18.3 4.8 0.0014 18.3 4.8 3.6 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 PIK58010.1 - 0.0019 18.3 4.6 0.0019 18.3 4.6 4.3 3 2 1 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 PIK58010.1 - 0.0072 16.1 9.7 0.0072 16.1 9.7 4.8 3 2 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-WRNIP1_ubi PF18279.1 PIK58010.1 - 0.63 10.8 0.1 0.63 10.8 0.1 3.7 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C2H2_4 PF13894.6 PIK58010.1 - 1.7 9.7 0.1 1.7 9.7 0.1 5.1 6 0 0 6 6 5 0 C2H2-type zinc finger Med25 PF11232.8 PIK58011.1 - 5.2e-18 65.5 0.0 1.2e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit 25 PTOV activation and synapsin 2 PHD PF00628.29 PIK58011.1 - 9.4e-09 35.0 9.0 9.4e-09 35.0 9.0 2.0 2 0 0 2 2 2 1 PHD-finger Bromodomain PF00439.25 PIK58011.1 - 3.5e-05 23.8 0.1 7.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Bromodomain C1_1 PF00130.22 PIK58011.1 - 0.46 10.4 6.7 1.1 9.2 4.5 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.6 PIK58011.1 - 0.84 9.8 3.9 0.42 10.8 0.8 2.1 2 0 0 2 2 2 0 PHD-zinc-finger like domain Zf_RING PF16744.5 PIK58011.1 - 1.4 9.1 8.3 29 4.9 8.3 2.6 1 1 0 1 1 1 0 KIAA1045 RING finger Ras PF00071.22 PIK58012.1 - 5.7e-41 139.8 0.1 7.1e-41 139.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK58012.1 - 4e-13 49.6 0.1 6.9e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK58012.1 - 2.6e-07 30.3 0.1 4.4e-07 29.5 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK58012.1 - 7.9e-05 22.7 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 PIK58012.1 - 0.016 14.6 0.6 0.073 12.4 0.0 2.1 2 1 0 2 2 2 0 AIG1 family AAA_22 PF13401.6 PIK58012.1 - 0.082 13.2 0.0 0.35 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 PIK58012.1 - 0.12 12.8 0.3 0.34 11.3 0.3 1.9 1 1 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 PIK58012.1 - 0.19 10.7 1.1 4.3 6.2 0.0 2.4 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TIP49 PF06068.13 PIK58013.1 - 2.1e-172 573.2 0.4 2.6e-172 572.9 0.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 PIK58013.1 - 1.3e-23 82.8 0.1 5e-23 81.0 0.1 2.1 1 0 0 1 1 1 1 TIP49 AAA-lid domain RuvB_N PF05496.12 PIK58013.1 - 6.5e-13 48.7 0.3 4e-09 36.4 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 PIK58013.1 - 2e-12 47.6 0.7 2.3e-08 34.5 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK58013.1 - 6.3e-08 33.0 0.3 0.0052 17.1 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 PIK58013.1 - 3.2e-05 24.4 0.0 0.0012 19.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK58013.1 - 6.6e-05 22.9 0.1 0.011 15.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 PIK58013.1 - 0.00028 20.6 0.1 0.42 10.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain DnaB_C PF03796.15 PIK58013.1 - 0.00033 20.1 0.0 0.00066 19.1 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 PIK58013.1 - 0.00033 20.3 0.2 0.0011 18.6 0.0 1.9 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 PIK58013.1 - 0.00034 20.0 0.3 0.022 14.1 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 PIK58013.1 - 0.00041 20.9 0.0 0.0057 17.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK58013.1 - 0.0014 18.3 0.1 0.0032 17.2 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 PIK58013.1 - 0.0017 18.7 1.8 0.066 13.5 1.8 2.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 PIK58013.1 - 0.0021 18.3 0.1 0.0047 17.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK58013.1 - 0.0031 17.5 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 PIK58013.1 - 0.0033 17.6 0.0 0.061 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 PIK58013.1 - 0.0045 16.3 0.2 0.027 13.7 0.1 2.2 2 0 0 2 2 2 1 Zeta toxin ResIII PF04851.15 PIK58013.1 - 0.0063 16.5 0.1 0.23 11.4 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 PIK58013.1 - 0.012 15.7 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 PIK58013.1 - 0.014 15.4 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 PIK58013.1 - 0.015 14.4 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 PIK58013.1 - 0.019 14.4 0.1 0.053 13.0 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 PIK58013.1 - 0.025 14.4 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK58013.1 - 0.031 13.8 0.1 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 PIK58013.1 - 0.036 13.8 0.8 1.3 8.7 0.1 2.7 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 PIK58013.1 - 0.036 13.4 0.8 0.24 10.7 0.0 2.3 2 1 0 2 2 2 0 KaiC NTPase_1 PF03266.15 PIK58013.1 - 0.048 13.6 0.5 0.18 11.7 0.0 2.3 3 0 0 3 3 2 0 NTPase AAA_17 PF13207.6 PIK58013.1 - 0.065 13.7 0.3 0.91 10.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 PIK58013.1 - 0.077 12.0 0.2 0.24 10.4 0.0 1.9 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF2075 PF09848.9 PIK58013.1 - 0.087 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 PIK58013.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Fibrinogen_C PF00147.18 PIK58014.1 - 3.4e-39 134.9 2.7 3.4e-39 134.9 2.7 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58014.1 - 3.1e-09 36.6 11.6 3.1e-09 36.6 11.6 3.4 1 1 2 3 3 3 2 TILa domain TIL PF01826.17 PIK58014.1 - 0.00011 22.4 12.7 0.00011 22.4 12.7 3.4 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK58014.1 - 2 8.5 27.9 0.12 12.5 4.6 3.3 3 0 0 3 3 3 0 MSP1 EGF domain 1 Ion_trans PF00520.31 PIK58015.1 - 5.8e-12 45.4 5.0 8.8e-12 44.8 5.0 1.2 1 0 0 1 1 1 1 Ion transport protein UPF0184 PF03670.13 PIK58015.1 - 0.099 13.0 0.9 0.25 11.7 0.9 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF4763 PF15960.5 PIK58015.1 - 0.11 11.8 3.4 0.33 10.2 2.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) DUF1664 PF07889.12 PIK58015.1 - 0.2 11.7 0.4 0.53 10.3 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PKD_channel PF08016.12 PIK58015.1 - 1.4 7.5 9.2 6.4 5.3 9.2 1.8 1 1 0 1 1 1 0 Polycystin cation channel Pkinase PF00069.25 PIK58016.1 - 1.2e-07 31.4 0.0 1.4e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58016.1 - 1.5e-05 24.4 0.0 1.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SMP_LBD PF17047.5 PIK58016.1 - 0.13 11.7 0.0 0.24 10.8 0.0 1.6 1 1 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain SH2 PF00017.24 PIK58017.1 - 2.8e-11 43.4 0.0 7.1e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 SH2 domain WW PF00397.26 PIK58017.1 - 0.016 15.3 0.1 0.079 13.1 0.0 2.3 2 1 0 2 2 2 0 WW domain Ad_cyc_g-alpha PF08509.11 PIK58017.1 - 3.2 7.5 4.6 0.6 9.9 0.2 2.1 3 0 0 3 3 3 0 Adenylate cyclase G-alpha binding domain DUF4651 PF15513.6 PIK58018.1 - 0.00037 20.2 0.3 4.5 7.2 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4651) Peptidase_S7 PF00949.21 PIK58018.1 - 0.0016 18.3 0.5 11 5.8 0.0 3.2 3 0 0 3 3 3 2 Peptidase S7, Flavivirus NS3 serine protease IFN-gamma PF00714.17 PIK58018.1 - 0.0059 16.5 0.9 18 5.1 0.0 3.1 3 0 0 3 3 3 0 Interferon gamma P_proprotein PF01483.20 PIK58018.1 - 0.012 15.7 0.1 6.6 6.8 0.0 2.5 2 1 0 2 2 2 0 Proprotein convertase P-domain CX PF01705.19 PIK58018.1 - 0.021 15.4 0.3 9 6.9 0.1 2.5 2 0 0 2 2 2 0 CX module bMG6 PF17962.1 PIK58018.1 - 0.021 15.0 0.0 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial macroglobulin domain 6 Acetyltransf_17 PF17668.1 PIK58018.1 - 0.067 14.0 0.0 20 6.0 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2259 PF10016.9 PIK58018.1 - 0.07 13.1 0.5 14 5.6 0.0 2.4 2 1 0 2 2 2 0 Predicted secreted protein (DUF2259) Inhibitor_I66 PF16850.5 PIK58018.1 - 0.097 12.5 0.0 12 5.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase inhibitor I66 DUF150 PF02576.17 PIK58018.1 - 0.17 12.3 0.1 35 4.9 0.0 2.4 2 0 0 2 2 2 0 RimP N-terminal domain NTP_transferase PF00483.23 PIK58019.1 - 1.6e-52 178.6 0.0 2e-52 178.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 PIK58019.1 - 9.9e-12 45.5 0.0 1.3e-11 45.1 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 PIK58019.1 - 1.1e-09 37.6 6.5 3.7e-09 35.9 3.5 2.7 1 1 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 PIK58019.1 - 2.9e-05 23.7 4.5 8.8e-05 22.2 2.6 2.7 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 PIK58019.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 PIK58019.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Tam41_Mmp37 PF09139.11 PIK58020.1 - 4.4e-112 374.7 1.0 5.1e-112 374.5 1.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial I-set PF07679.16 PIK58021.1 - 1.7e-09 37.6 0.0 3.1e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_8 PF13855.6 PIK58021.1 - 2.3e-09 36.8 3.8 4.2e-09 36.0 3.8 1.4 1 0 0 1 1 1 1 Leucine rich repeat Ig_3 PF13927.6 PIK58021.1 - 2.3e-07 31.3 0.0 4.8e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_4 PF12799.7 PIK58021.1 - 0.00013 22.3 2.6 0.00029 21.1 2.6 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRRCT PF01463.24 PIK58021.1 - 0.025 15.1 0.0 0.06 13.9 0.0 1.7 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain PRIMA1 PF16101.5 PIK58021.1 - 0.079 13.0 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ig PF00047.25 PIK58021.1 - 0.091 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain WD40 PF00400.32 PIK58022.1 - 1.4e-05 25.8 0.0 0.55 11.2 0.0 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58022.1 - 6.8e-05 23.1 0.0 9.8 6.6 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Hormone_5 PF00184.17 PIK58023.1 - 0.51 11.2 4.6 1.3 9.8 4.8 1.6 1 1 0 1 1 1 0 Neurohypophysial hormones, C-terminal Domain Tmemb_40 PF10160.9 PIK58024.1 - 9.3e-71 238.3 16.6 1.2e-70 237.9 16.6 1.1 1 0 0 1 1 1 1 Predicted membrane protein MCM PF00493.23 PIK58025.1 - 3.3e-101 337.1 0.0 5.3e-101 336.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK58025.1 - 9.4e-36 122.4 0.0 1.9e-35 121.5 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK58025.1 - 6.5e-28 97.0 1.5 2.2e-27 95.3 1.5 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 PIK58025.1 - 1.9e-17 63.7 1.2 6e-17 62.1 1.2 1.8 1 0 0 1 1 1 1 MCM N-terminal domain MCM2_N PF12619.8 PIK58025.1 - 1.7e-16 60.8 22.1 5.1e-16 59.3 20.7 2.2 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 Mg_chelatase PF01078.21 PIK58025.1 - 7.6e-09 35.2 0.0 1e-06 28.3 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK58025.1 - 4.5e-07 30.0 0.0 3e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK58025.1 - 3.1e-05 23.8 0.0 0.0004 20.3 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK58025.1 - 0.005 16.6 0.0 0.96 9.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 PIK58025.1 - 0.078 13.4 0.0 0.29 11.6 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 PIK58025.1 - 0.08 12.8 1.3 0.57 10.1 0.0 2.8 3 0 0 3 3 3 0 AAA lid domain DUF2274 PF10038.9 PIK58025.1 - 0.1 13.1 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Zn-ribbon_8 PF09723.10 PIK58025.1 - 0.47 10.6 1.9 1.2 9.3 1.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain DUF720 PF05302.11 PIK58026.1 - 0.0027 17.6 1.0 0.0038 17.1 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF720) RNase_P_Rpp14 PF01900.19 PIK58029.1 - 6.2e-10 39.2 0.0 7.7e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Cyclin_N PF00134.23 PIK58030.1 - 2.6e-13 49.8 0.3 1.5e-12 47.3 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain WD40 PF00400.32 PIK58031.1 - 6.9e-64 210.3 17.3 1.7e-10 41.3 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58031.1 - 3.5e-22 78.5 0.4 6.8e-05 23.1 0.1 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK58031.1 - 1.6e-12 47.7 0.3 1.5e-07 31.5 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 PIK58031.1 - 5.3e-09 35.5 3.3 0.051 12.5 0.2 4.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 PIK58031.1 - 1.8e-05 23.5 0.0 0.063 11.8 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 PIK58031.1 - 0.0011 18.3 0.0 31 3.7 0.0 4.5 2 1 2 5 5 5 0 WD40-like domain Frtz PF11768.8 PIK58031.1 - 0.0074 14.7 0.0 0.32 9.3 0.0 2.8 2 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 PIK58031.1 - 0.042 12.6 0.4 0.29 9.8 0.2 2.3 2 1 0 2 2 2 0 Nup133 N terminal like Proteasome_A_N PF10584.9 PIK58031.1 - 0.069 12.8 0.6 6.7 6.5 0.0 3.4 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ELFV_dehydrog PF00208.21 PIK58032.1 - 3.4e-11 43.3 0.2 4.5e-07 29.8 0.3 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 PIK58032.1 - 6.5e-05 22.8 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Shikimate_DH PF01488.20 PIK58032.1 - 0.0012 18.9 0.1 0.0024 18.0 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 PIK58032.1 - 0.0047 17.3 0.1 0.01 16.2 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding TrkA_N PF02254.18 PIK58032.1 - 0.012 15.9 0.3 0.036 14.3 0.3 1.8 2 0 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.17 PIK58032.1 - 0.026 15.1 0.0 0.053 14.1 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PDZ PF00595.24 PIK58034.1 - 1.9e-22 79.4 0.6 1.4e-15 57.4 0.1 2.8 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK58034.1 - 4.4e-14 52.1 0.4 4.8e-07 29.5 0.1 2.8 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 PIK58034.1 - 2e-10 40.9 1.4 1.7e-05 25.1 0.1 3.5 2 1 1 3 3 3 2 PDZ domain WASH-7_N PF14745.6 PIK58035.1 - 2.1e-233 776.0 7.7 2.1e-233 776.0 7.7 2.1 2 0 0 2 2 2 1 WASH complex subunit 7, N-terminal WASH-7_mid PF14744.6 PIK58035.1 - 6.5e-169 561.5 9.1 6.5e-169 561.5 9.1 2.0 2 0 0 2 2 2 1 WASH complex subunit 7 WASH-7_C PF14746.6 PIK58035.1 - 4.8e-72 241.3 4.6 1.5e-71 239.7 4.6 1.9 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Pkinase PF00069.25 PIK58036.1 - 5.3e-41 140.7 6.7 1.2e-31 110.1 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58036.1 - 8.3e-25 87.5 0.0 7.8e-21 74.5 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Spc7 PF08317.11 PIK58036.1 - 0.16 10.9 24.2 0.34 9.7 24.2 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 PIK58036.1 - 1 9.4 24.7 3.5 7.7 24.7 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 PIK58036.1 - 2.8 7.4 17.0 7.9 5.9 17.0 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 PIK58036.1 - 4.7 6.5 14.4 7.7 5.8 14.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 PIK58036.1 - 9.5 5.2 22.5 26 3.8 22.5 1.8 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ECH_1 PF00378.20 PIK58037.1 - 1.7e-19 70.1 0.2 1e-18 67.6 0.1 2.0 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK58037.1 - 2.8e-15 56.7 0.4 2.7e-13 50.2 0.1 2.2 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase HisKA_4TM PF16926.5 PIK58037.1 - 0.016 14.8 0.2 0.24 11.0 0.1 2.1 1 1 1 2 2 2 0 Archaeal 4TM region of histidine kinase Ge1_WD40 PF16529.5 PIK58038.1 - 7e-62 209.3 0.0 3.7e-61 206.9 0.0 2.0 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 PIK58038.1 - 2.8e-08 34.3 0.1 1.1e-05 26.1 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Spo0A_C PF08769.11 PIK58038.1 - 1.2 9.3 3.8 25 5.0 0.1 3.3 2 1 0 3 3 3 0 Sporulation initiation factor Spo0A C terminal HSBP1 PF06825.12 PIK58038.1 - 1.2 9.0 11.9 0.49 10.3 1.2 3.3 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DUF2433 PF10360.9 PIK58038.1 - 2.2 8.4 4.5 4.2 7.5 2.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2433) TetR_C_24 PF17932.1 PIK58038.1 - 9 6.6 8.0 1.8 8.9 0.6 3.3 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF4503 PF14951.6 PIK58039.1 - 1.2e-58 198.5 0.5 1.7e-58 198.0 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) DUF4502 PF14950.6 PIK58039.1 - 5.9e-14 52.3 30.3 2.2e-12 47.1 29.1 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF4502) TMEM189_B_dmain PF10520.9 PIK58040.1 - 2.5e-73 245.9 4.6 3.7e-73 245.3 4.6 1.2 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain FtsX PF02687.21 PIK58040.1 - 3.8 8.0 5.9 12 6.5 5.9 1.8 1 1 0 1 1 1 0 FtsX-like permease family RRM_1 PF00076.22 PIK58041.1 - 5.5e-21 74.2 0.0 2.4e-05 24.0 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 PIK58041.1 - 0.00024 21.7 0.0 0.00047 20.7 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Imm7 PF15585.6 PIK58041.1 - 0.029 14.7 0.0 0.49 10.7 0.0 2.4 1 1 1 2 2 2 0 Immunity protein 7 LIM PF00412.22 PIK58042.1 - 5.7e-23 80.9 23.9 4.2e-11 42.9 5.6 3.3 3 0 0 3 3 3 3 LIM domain ECH_1 PF00378.20 PIK58043.1 - 1.9e-50 171.6 0.0 3.3e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.19 PIK58043.1 - 1e-23 83.3 0.4 3.2e-23 81.7 0.4 1.8 1 0 0 1 1 1 1 Acyl CoA binding protein ECH_2 PF16113.5 PIK58043.1 - 4.9e-21 75.6 0.0 7.4e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CSRNP_N PF16019.5 PIK58044.1 - 0.18 11.7 1.1 0.26 11.2 1.1 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PNMA PF14893.6 PIK58045.1 - 5.8e-11 42.4 0.0 8.5e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.23 PIK58045.1 - 8.1e-07 28.8 0.6 1.4e-06 28.1 0.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK58045.1 - 0.0014 18.3 0.4 0.0027 17.4 0.4 1.5 1 0 0 1 1 1 1 Zinc knuckle CdiA_C PF18451.1 PIK58045.1 - 0.012 15.8 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 Contact-dependent growth inhibition CdiA C-terminal domain zf-CCHC_6 PF15288.6 PIK58045.1 - 0.027 14.3 1.1 0.027 14.3 1.1 1.8 2 0 0 2 2 2 0 Zinc knuckle CS PF04969.16 PIK58046.1 - 8.9e-16 58.7 0.0 4.3e-15 56.5 0.0 2.2 2 0 0 2 2 2 1 CS domain MRPL52 PF18699.1 PIK58047.1 - 7e-29 99.9 2.0 7e-29 99.9 2.0 1.5 2 0 0 2 2 2 1 Mitoribosomal protein mL52 Drc1-Sld2 PF11719.8 PIK58048.1 - 5.1e-10 39.5 2.5 5.1e-10 39.5 2.5 2.5 2 1 0 2 2 2 1 DNA replication and checkpoint protein DEAD PF00270.29 PIK58050.1 - 2.3e-09 37.3 0.0 2.3e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK58050.1 - 0.0056 16.7 0.0 0.0058 16.6 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK58051.1 - 2.3e-14 53.7 0.1 1.4e-13 51.2 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Pep_M12B_propep PF01562.19 PIK58052.1 - 4e-38 130.8 0.0 7.9e-38 129.8 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 PIK58052.1 - 2.3e-35 121.1 0.0 3.8e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 PIK58052.1 - 2.1e-25 89.8 0.0 4e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 PIK58052.1 - 2.7e-19 69.5 3.1 2.7e-19 69.5 3.1 6.2 5 1 1 6 6 6 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 PIK58052.1 - 1.2e-12 48.5 0.2 1.2e-12 48.5 0.2 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12 TSP_1 PF00090.19 PIK58052.1 - 1.7e-12 47.4 45.0 4e-07 30.2 8.8 5.1 4 0 0 4 4 4 3 Thrombospondin type 1 domain PLAC PF08686.11 PIK58052.1 - 1.2e-07 32.3 8.8 1.2e-07 32.3 8.8 2.4 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Reprolysin_3 PF13582.6 PIK58052.1 - 2.8e-07 31.1 0.0 5.3e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK58052.1 - 3e-06 27.3 0.2 7.1e-06 26.0 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK58052.1 - 0.00043 20.0 0.1 0.001 18.8 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like adh_short PF00106.25 PIK58053.1 - 6.5e-26 91.0 0.0 6.3e-23 81.2 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase WW PF00397.26 PIK58053.1 - 6.2e-17 61.4 1.0 3.4e-10 39.8 0.6 2.4 2 0 0 2 2 2 2 WW domain adh_short_C2 PF13561.6 PIK58053.1 - 1.8e-15 57.1 0.0 2.9e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK58053.1 - 7.6e-07 29.2 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK58053.1 - 0.0036 16.8 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Acetyltransf_2 PF00797.17 PIK58055.1 - 1.3e-06 28.4 0.1 5.8e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 N-acetyltransferase DUF4810 PF16068.5 PIK58056.1 - 0.33 11.5 2.7 0.64 10.6 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) DUF872 PF05915.12 PIK58056.1 - 0.67 10.1 2.3 2.8 8.2 2.3 2.2 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) MORN PF02493.20 PIK58058.1 - 4.7e-20 70.2 41.4 7.7e-07 28.6 1.5 6.7 6 1 0 6 6 6 5 MORN repeat PI-PLC-X PF00388.19 PIK58059.1 - 6.8e-62 207.4 0.0 1.4e-61 206.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 PIK58059.1 - 3.6e-11 43.0 0.0 9.6e-11 41.6 0.0 1.8 1 0 0 1 1 1 1 SH2 domain EF-hand_like PF09279.11 PIK58059.1 - 7.4e-06 26.4 1.3 7.4e-06 26.4 1.3 2.0 3 0 0 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like PH_12 PF16457.5 PIK58059.1 - 0.00089 19.8 0.2 0.003 18.1 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain DIX PF00778.17 PIK58059.1 - 0.0012 18.6 0.5 0.047 13.5 0.2 3.2 3 0 0 3 3 3 1 DIX domain PH PF00169.29 PIK58059.1 - 0.0087 16.6 0.0 1.6 9.3 0.0 3.4 3 0 0 3 3 3 1 PH domain Beta-Casp PF10996.8 PIK58059.1 - 0.015 15.6 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 Beta-Casp domain GDPD PF03009.17 PIK58059.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family EF-hand_10 PF14788.6 PIK58059.1 - 0.055 13.3 0.4 0.12 12.2 0.4 1.6 1 0 0 1 1 1 0 EF hand PI-PLC-Y PF00387.19 PIK58060.1 - 7.1e-39 132.7 0.0 1.6e-38 131.6 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 PIK58060.1 - 8.6e-16 58.1 0.0 2e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain SH2 PF00017.24 PIK58060.1 - 5.1e-15 55.3 0.1 1.1e-14 54.3 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK58060.1 - 2.1e-12 46.4 0.4 4.8e-12 45.3 0.4 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK58060.1 - 8.4e-09 35.2 0.2 3.4e-08 33.2 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain PH PF00169.29 PIK58060.1 - 3.8e-07 30.6 0.0 8.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 PIK58060.1 - 1.3e-05 24.8 0.0 2.9e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH2 PF00017.24 PIK58061.1 - 3.1e-21 75.2 0.7 6.3e-21 74.3 0.3 1.8 2 0 0 2 2 2 1 SH2 domain PI-PLC-Y PF00387.19 PIK58062.1 - 9.5e-42 142.0 1.2 2.9e-41 140.4 0.1 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 PIK58062.1 - 3e-17 62.8 0.0 5.4e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain rve PF00665.26 PIK58063.1 - 2.2e-19 69.8 0.0 3.2e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58063.1 - 0.0018 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK58063.1 - 0.049 13.9 0.0 0.078 13.2 0.0 1.2 1 0 0 1 1 1 0 DDE domain RT_RNaseH_2 PF17919.1 PIK58064.1 - 2.8e-17 62.6 0.0 6.5e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58064.1 - 7.8e-08 32.1 0.2 3.6e-05 23.4 0.1 2.7 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK58064.1 - 3.8e-05 23.9 0.0 8.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58065.1 - 5.2e-19 68.6 0.5 3.7e-14 52.8 0.1 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK58065.1 - 7.9e-18 64.8 0.0 1.6e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58065.1 - 0.00028 20.6 0.2 0.00071 19.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK58066.1 - 1.1e-06 28.5 14.9 0.018 15.1 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-C2H2_10 PF16588.5 PIK58066.1 - 0.0029 17.3 4.8 0.0082 15.8 0.6 2.7 2 0 0 2 2 2 1 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK58066.1 - 0.0083 15.9 9.6 0.27 11.1 6.5 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK58066.1 - 0.036 14.0 14.1 0.16 11.9 1.7 3.6 3 1 1 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK58066.1 - 0.058 13.1 8.6 2.1 8.1 0.3 3.2 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK58066.1 - 0.38 10.6 0.0 0.38 10.6 0.0 3.5 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC PF00098.23 PIK58068.1 - 3.8e-05 23.6 15.2 0.0026 17.8 3.3 2.9 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK58068.1 - 0.00011 21.8 14.4 0.22 11.3 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK58068.1 - 0.0023 17.7 0.2 0.0023 17.7 0.2 2.8 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK58068.1 - 1.6 9.0 12.0 0.51 10.6 6.6 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain YhfH PF14149.6 PIK58068.1 - 5.6 7.0 8.9 0.54 10.3 2.7 2.1 2 0 0 2 2 2 0 YhfH-like protein RVT_1 PF00078.27 PIK58069.1 - 8.9e-19 67.9 0.0 1.2e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AA_permease_2 PF13520.6 PIK58070.1 - 8e-15 54.6 13.8 9.5e-15 54.3 13.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK58070.1 - 0.00017 20.3 11.3 0.00027 19.7 11.3 1.4 1 1 0 1 1 1 1 Amino acid permease DUF563 PF04577.14 PIK58071.1 - 9.8e-20 71.6 0.1 2.2e-19 70.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) adh_short_C2 PF13561.6 PIK58072.1 - 7.6e-44 150.0 0.1 1.1e-43 149.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK58072.1 - 5.7e-36 123.8 0.1 8.7e-36 123.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK58072.1 - 1.8e-09 37.8 0.1 3.3e-09 36.9 0.1 1.4 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 PIK58072.1 - 0.017 15.7 0.4 0.038 14.6 0.4 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 PIK58072.1 - 0.034 14.0 0.3 0.062 13.2 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 PIK58072.1 - 0.048 12.8 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sas10_Utp3 PF04000.15 PIK58073.1 - 1.5e-16 60.8 0.5 1.5e-16 60.8 0.5 2.5 2 1 0 2 2 2 1 Sas10/Utp3/C1D family FATC PF02260.20 PIK58073.1 - 0.02 14.7 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 FATC domain Spidroin_MaSp PF11260.8 PIK58073.1 - 0.11 12.8 0.4 0.24 11.7 0.4 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 AIG2_2 PF13772.6 PIK58074.1 - 3e-40 136.5 0.4 2.4e-20 72.7 0.0 2.3 2 0 0 2 2 2 2 AIG2-like family GGACT PF06094.12 PIK58074.1 - 3.8e-14 53.3 0.0 1.3e-05 25.8 0.0 2.4 2 0 0 2 2 2 2 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 PIK58075.1 - 2.5e-19 69.5 0.0 3.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 PIK58075.1 - 1.5e-05 25.5 0.1 3.3e-05 24.5 0.1 1.5 1 1 1 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like EamA PF00892.20 PIK58076.1 - 8.7e-26 90.7 30.2 1.8e-13 50.8 14.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK58076.1 - 8.3e-05 22.1 20.5 0.0093 15.3 20.5 2.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family TPR_12 PF13424.6 PIK58077.1 - 2.3e-25 88.7 16.0 1.5e-08 34.8 1.1 5.8 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 PIK58077.1 - 1.1e-20 72.5 16.1 0.038 13.8 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 PIK58077.1 - 2.4e-19 67.8 17.0 0.014 15.5 0.2 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK58077.1 - 4.8e-19 66.9 11.5 0.0013 18.7 0.0 8.6 9 0 0 9 9 7 4 Tetratricopeptide repeat Ank_2 PF12796.7 PIK58077.1 - 3e-18 66.2 0.5 1e-10 42.0 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK58077.1 - 1e-17 64.2 0.1 3.9e-10 40.1 0.1 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK58077.1 - 1.2e-17 63.8 0.5 4.2e-07 30.1 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) TPR_8 PF13181.6 PIK58077.1 - 4.5e-17 60.8 12.6 0.014 15.5 0.1 8.1 8 0 0 8 8 7 5 Tetratricopeptide repeat Ank_3 PF13606.6 PIK58077.1 - 1.3e-14 52.8 0.4 0.00059 20.1 0.2 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 PIK58077.1 - 5.2e-14 52.0 0.4 2.3e-05 24.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat TPR_11 PF13414.6 PIK58077.1 - 2.1e-10 40.1 4.8 0.096 12.4 0.0 6.5 6 0 0 6 6 6 3 TPR repeat TPR_16 PF13432.6 PIK58077.1 - 5.5e-09 36.5 4.2 0.059 14.0 0.2 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK58077.1 - 9.6e-09 35.0 17.3 1.3e-05 24.8 0.3 3.7 1 1 1 3 3 3 2 MalT-like TPR region TPR_10 PF13374.6 PIK58077.1 - 1.7e-08 34.0 2.2 0.17 11.8 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK58077.1 - 6.2e-08 32.8 5.2 5.3 8.1 0.0 7.3 5 2 2 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK58077.1 - 0.00032 21.2 10.5 0.38 11.3 0.4 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK58077.1 - 0.00034 20.8 1.0 16 6.1 0.0 5.9 5 1 0 5 5 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 PIK58077.1 - 0.00088 18.7 0.9 0.015 14.8 1.0 3.0 2 0 0 2 2 2 1 SHNi-TPR RPN7 PF10602.9 PIK58077.1 - 0.0027 17.5 15.6 0.058 13.1 1.1 4.2 1 1 2 3 3 3 2 26S proteasome subunit RPN7 ANAPC3 PF12895.7 PIK58077.1 - 0.0086 16.3 18.0 10 6.5 0.1 6.6 5 2 2 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK58077.1 - 0.021 15.0 1.7 14 5.9 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat MA-Mit PF09245.10 PIK58077.1 - 0.031 13.8 0.2 0.094 12.2 0.1 1.8 2 0 0 2 2 1 0 Mycoplasma arthritidis-derived mitogen TPR_4 PF07721.14 PIK58077.1 - 0.068 13.8 0.1 45 5.1 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 PIK58077.1 - 0.18 12.2 4.1 36 4.9 0.0 5.7 7 0 0 7 7 5 0 PPR repeat Rapsyn_N PF10579.9 PIK58077.1 - 0.25 11.5 2.4 29 4.9 0.2 4.0 3 1 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region Gastrin PF00918.17 PIK58077.1 - 0.88 10.5 0.0 0.88 10.5 0.0 3.2 3 0 0 3 3 3 0 Gastrin/cholecystokinin family HemY_N PF07219.13 PIK58077.1 - 1 9.6 6.3 1.2 9.3 0.8 3.3 2 1 1 3 3 3 0 HemY protein N-terminus CAF1A PF12253.8 PIK58077.1 - 3.4 7.9 7.3 11 6.3 7.3 1.8 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A TPR_6 PF13174.6 PIK58077.1 - 3.7 8.4 9.3 2.3e+02 2.7 0.0 6.6 8 0 0 8 8 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK58078.1 - 3.4e-21 75.3 9.0 2.3e-05 24.6 0.0 6.2 4 2 1 6 6 6 4 Tetratricopeptide repeat LRR_6 PF13516.6 PIK58078.1 - 7.9e-12 44.2 25.1 0.02 14.9 0.0 9.0 10 0 0 10 10 10 4 Leucine Rich repeat TPR_1 PF00515.28 PIK58078.1 - 2.4e-11 42.9 4.6 0.0024 17.6 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK58078.1 - 6.9e-11 41.4 8.0 0.17 12.1 0.0 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK58078.1 - 7.2e-08 32.1 13.1 0.021 15.0 0.0 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK58078.1 - 3.1e-07 30.0 4.4 0.93 9.7 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat LRR_4 PF12799.7 PIK58078.1 - 6e-06 26.5 20.9 0.2 12.1 1.2 6.8 6 1 1 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK58078.1 - 2.7e-05 23.8 15.9 0.13 12.1 0.0 5.8 5 1 0 5 5 5 2 Leucine rich repeat TPR_14 PF13428.6 PIK58078.1 - 4.9e-05 23.8 0.0 0.73 10.8 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK58078.1 - 5.9e-05 23.6 0.0 5.6 7.7 0.0 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC5 PF12862.7 PIK58078.1 - 0.0037 17.3 0.6 1.9 8.6 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 PIK58078.1 - 0.038 13.9 1.2 17 5.4 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_1 PF00560.33 PIK58078.1 - 0.48 11.2 12.4 70 4.6 0.0 6.8 7 0 0 7 7 7 0 Leucine Rich Repeat TPR_11 PF13414.6 PIK58078.1 - 7.8 6.3 9.1 6.4 6.5 0.1 4.5 6 1 0 6 6 6 0 TPR repeat Med10 PF09748.9 PIK58079.1 - 1.5e-34 118.6 0.3 1.6e-34 118.4 0.3 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex UvrD_C PF13361.6 PIK58079.1 - 0.012 15.1 0.3 0.014 14.8 0.3 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Septin PF00735.18 PIK58080.1 - 3.7e-111 370.9 0.0 3.7e-111 370.9 0.0 1.9 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 PIK58080.1 - 2.5e-08 34.0 0.3 7.5e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK58080.1 - 3.4e-05 23.8 5.2 9.2e-05 22.4 0.1 3.1 3 0 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 PIK58080.1 - 8.5e-05 22.0 0.0 8.5e-05 22.0 0.0 2.2 2 0 0 2 2 1 1 AIG1 family AAA_23 PF13476.6 PIK58080.1 - 0.00066 20.2 7.1 0.37 11.3 6.2 2.3 2 0 0 2 2 2 2 AAA domain Exonuc_VII_L PF02601.15 PIK58080.1 - 0.0012 18.5 3.8 0.0015 18.2 3.8 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit Gtr1_RagA PF04670.12 PIK58080.1 - 0.0013 18.2 0.0 0.0013 18.2 0.0 2.8 3 0 0 3 3 2 1 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK58080.1 - 0.0039 16.8 1.8 0.0042 16.7 0.0 1.9 2 0 0 2 2 2 1 Ras family ABC_tran PF00005.27 PIK58080.1 - 0.0042 17.6 2.1 0.044 14.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter GAS PF13851.6 PIK58080.1 - 0.0093 15.3 19.3 0.021 14.2 19.3 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding FeoB_N PF02421.18 PIK58080.1 - 0.01 15.4 0.1 0.024 14.2 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 PIK58080.1 - 0.011 16.2 0.5 0.023 15.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 PIK58080.1 - 0.012 15.8 0.7 0.051 13.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 PIK58080.1 - 0.037 14.2 1.4 0.076 13.2 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 PIK58080.1 - 0.049 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain COG2 PF06148.11 PIK58080.1 - 0.081 13.0 7.7 0.25 11.4 7.7 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 RNA_helicase PF00910.22 PIK58080.1 - 0.33 11.4 3.3 1.5 9.3 0.0 3.0 3 0 0 3 3 3 0 RNA helicase DUF87 PF01935.17 PIK58080.1 - 0.34 11.0 4.6 6.6 6.8 2.4 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain TFIIF_beta_N PF17683.1 PIK58080.1 - 0.76 10.5 7.5 1.5 9.6 7.5 1.4 1 0 0 1 1 1 0 TFIIF, beta subunit N-terminus GTP_EFTU PF00009.27 PIK58080.1 - 1 8.9 11.2 0.82 9.2 0.1 3.8 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain MutS_III PF05192.18 PIK58080.1 - 1.1 9.5 3.8 1.9 8.7 3.8 1.4 1 0 0 1 1 1 0 MutS domain III DUF4407 PF14362.6 PIK58080.1 - 2.1 7.6 5.5 2.9 7.2 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dynamin_N PF00350.23 PIK58080.1 - 2.2 8.3 18.2 0.74 9.8 0.3 3.7 2 2 1 3 3 2 0 Dynamin family FapA PF03961.13 PIK58080.1 - 2.3 6.7 10.7 3.4 6.2 10.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Atg14 PF10186.9 PIK58080.1 - 2.8 6.9 13.2 4.4 6.3 13.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4523 PF15023.6 PIK58081.1 - 2.4e-13 50.3 0.1 3.5e-13 49.7 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4523) RRM_1 PF00076.22 PIK58081.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_2 PF00002.24 PIK58082.1 - 1.1e-15 57.6 11.3 1.9e-15 56.8 11.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Lectin_C PF00059.21 PIK58082.1 - 4.3e-14 53.1 0.0 4.3e-14 53.1 0.0 2.7 3 0 0 3 3 3 1 Lectin C-type domain GPS PF01825.21 PIK58082.1 - 2.5e-13 50.3 7.8 1.1e-12 48.2 7.8 2.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 PIK58082.1 - 2.2e-11 43.6 5.8 4.2e-11 42.7 0.0 3.0 2 1 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain EGF PF00008.27 PIK58082.1 - 3e-06 27.4 2.4 3e-06 27.4 2.4 2.4 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 PIK58082.1 - 0.0049 17.5 0.7 0.022 15.4 0.7 2.3 1 0 0 1 1 1 1 Human growth factor-like EGF Toxin_R_bind_N PF07953.12 PIK58082.1 - 0.019 14.7 5.3 0.18 11.5 4.9 2.4 2 0 0 2 2 2 0 Clostridium neurotoxin, N-terminal receptor binding Mss4 PF04421.13 PIK58084.1 - 3.1e-33 113.8 0.5 4.1e-33 113.4 0.0 1.4 2 0 0 2 2 2 1 Mss4 protein zf-ACC PF17848.1 PIK58084.1 - 0.14 12.3 0.2 0.14 12.3 0.2 2.1 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain HECT_2 PF09814.9 PIK58084.1 - 0.15 10.9 1.3 3.8 6.3 0.3 2.0 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding PNP_UDP_1 PF01048.20 PIK58085.1 - 2e-29 102.5 3.4 1.3e-20 73.7 0.3 2.0 1 1 1 2 2 2 2 Phosphorylase superfamily LBP_BPI_CETP_C PF02886.17 PIK58086.1 - 1.4e-42 145.8 0.2 2e-42 145.3 0.2 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain RTTN_N PF14726.6 PIK58087.1 - 8.2e-30 103.5 3.8 8.2e-30 103.5 3.8 4.0 3 0 0 3 3 3 1 Rotatin, an armadillo repeat protein, centriole functioning Arm PF00514.23 PIK58087.1 - 0.18 11.9 0.8 25 5.1 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF680 PF05079.12 PIK58087.1 - 0.2 12.4 1.6 0.58 10.9 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF680) CAP PF00188.26 PIK58088.1 - 4.5e-06 27.5 0.3 7.2e-06 26.9 0.3 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Atg8 PF02991.16 PIK58089.1 - 1.8e-47 159.8 0.0 2.4e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 PIK58089.1 - 1.3e-06 28.7 0.0 1.7e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 CLPTM1 PF05602.12 PIK58090.1 - 2.6e-122 409.0 0.3 3.1e-122 408.7 0.3 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 PIK58090.1 - 0.013 15.3 0.1 1.1 9.1 0.0 3.0 2 0 0 2 2 2 0 PQ loop repeat dsDNA_bind PF01984.20 PIK58091.1 - 1.2e-25 89.9 9.3 1.3e-25 89.8 9.3 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4808 PF16066.5 PIK58091.1 - 0.0083 16.7 0.3 0.0092 16.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) CDT1_C PF16679.5 PIK58091.1 - 0.8 10.2 7.0 1.2 9.7 7.0 1.3 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain RNase_PH PF01138.21 PIK58092.1 - 5.2e-24 85.2 0.0 1.2e-23 84.1 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK58092.1 - 6.1e-08 32.6 0.6 4.8e-07 29.7 0.0 2.2 2 1 0 2 2 2 1 3' exoribonuclease family, domain 2 A_deamin PF02137.18 PIK58093.1 - 2e-97 326.6 8.1 3.4e-96 322.6 8.1 2.2 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain Mem_trans PF03547.18 PIK58093.1 - 0.19 10.1 0.3 0.23 9.8 0.3 1.2 1 0 0 1 1 1 0 Membrane transport protein BRCA-2_helical PF09169.10 PIK58093.1 - 0.36 10.5 3.0 0.77 9.4 2.3 2.0 1 1 0 1 1 1 0 BRCA2, helical TM231 PF10149.9 PIK58094.1 - 1.9e-60 204.8 0.0 2.3e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 Transmembrane protein 231 adh_short PF00106.25 PIK58096.1 - 1.2e-53 181.5 0.0 1.6e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK58096.1 - 7e-30 104.3 0.0 1e-29 103.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK58096.1 - 2.2e-12 47.3 0.0 2.9e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 PIK58096.1 - 0.0012 18.0 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 PIK58096.1 - 0.0014 18.9 0.1 0.0024 18.2 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 PIK58096.1 - 0.0067 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ApbA PF02558.16 PIK58096.1 - 0.034 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3Beta_HSD PF01073.19 PIK58096.1 - 0.078 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 PIK58096.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Roc PF08477.13 PIK58097.1 - 3.7e-13 49.8 0.0 3.8e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 PIK58097.1 - 2.1e-11 43.7 0.0 2.2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 PIK58097.1 - 0.00061 19.3 0.0 0.00079 18.9 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 PIK58097.1 - 0.00095 19.5 0.1 0.0013 19.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 PIK58097.1 - 0.001 19.0 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 PIK58097.1 - 0.0025 18.2 0.0 0.0031 17.9 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 PIK58097.1 - 0.0039 17.3 0.0 0.0045 17.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_5 PF07728.14 PIK58097.1 - 0.0083 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK58097.1 - 0.011 15.2 0.2 0.083 12.4 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PduV-EutP PF10662.9 PIK58097.1 - 0.015 15.1 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation zf-CCCH PF00642.24 PIK58097.1 - 0.015 15.2 0.2 0.033 14.1 0.2 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Septin PF00735.18 PIK58097.1 - 0.015 14.6 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Septin G-alpha PF00503.20 PIK58097.1 - 0.028 13.6 0.0 0.035 13.3 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit NACHT PF05729.12 PIK58097.1 - 0.028 14.3 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 NACHT domain TniB PF05621.11 PIK58097.1 - 0.033 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 PIK58097.1 - 0.043 13.5 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 PIK58097.1 - 0.052 12.4 0.0 0.064 12.1 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) SRPRB PF09439.10 PIK58097.1 - 0.072 12.5 0.0 0.08 12.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 PIK58097.1 - 0.08 13.4 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 PIK58097.1 - 0.092 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 PIK58097.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.22 PIK58097.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 PIK58097.1 - 0.16 12.4 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Complex1_30kDa PF00329.19 PIK58098.1 - 5.3e-43 146.5 0.0 7.3e-43 146.1 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF4765 PF15962.5 PIK58098.1 - 0.065 11.2 0.1 0.078 10.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4765) SRP54 PF00448.22 PIK58099.1 - 0.081 12.5 1.0 0.12 12.0 0.6 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain DEP PF00610.21 PIK58100.1 - 7.2e-14 51.6 0.1 1.5e-13 50.6 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) S-methyl_trans PF02574.16 PIK58101.1 - 4.2e-42 144.8 0.1 5.2e-42 144.5 0.1 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase AP_endonuc_2 PF01261.24 PIK58101.1 - 0.0044 16.5 0.0 0.0095 15.4 0.0 1.6 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel RVT_1 PF00078.27 PIK58102.1 - 2.6e-22 79.4 0.0 3.5e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK58102.1 - 7.4e-06 25.5 0.0 0.00014 21.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) Peptidase_A17 PF05380.13 PIK58103.1 - 1.7e-58 197.2 0.1 2.3e-58 196.7 0.1 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase BBIP10 PF14777.6 PIK58103.1 - 0.014 15.0 0.0 0.038 13.6 0.0 1.7 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RVT_3 PF13456.6 PIK58103.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like Integrase_H2C2 PF17921.1 PIK58104.1 - 3.8e-09 36.5 0.3 7.7e-09 35.5 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK58104.1 - 1.3e-06 28.6 0.0 2.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Nse4-Nse3_bdg PF15412.6 PIK58104.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE Transposase_21 PF02992.14 PIK58105.1 - 2e-14 53.3 0.4 8.3e-14 51.3 0.0 1.9 2 0 0 2 2 2 1 Transposase family tnp2 DUF1258 PF06869.12 PIK58105.1 - 0.0092 15.5 1.8 0.02 14.4 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1258) S-methyl_trans PF02574.16 PIK58107.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.3 1 1 0 1 1 1 0 Homocysteine S-methyltransferase S-methyl_trans PF02574.16 PIK58108.1 - 6.6e-10 39.2 0.0 7.3e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase S-methyl_trans PF02574.16 PIK58109.1 - 2.3e-15 57.1 0.0 2.4e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase TMEM247 PF15444.6 PIK58110.1 - 0.078 13.0 12.0 0.11 12.6 12.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 BASP1 PF05466.12 PIK58110.1 - 0.68 9.9 12.5 1.1 9.2 12.5 1.3 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) DDE_Tnp_4 PF13359.6 PIK58111.1 - 5.2e-20 71.7 0.0 7.2e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 PIK58111.1 - 8.9e-05 22.2 0.0 0.00075 19.2 0.0 2.4 2 1 0 2 2 2 1 Transposase DDE domain S-methyl_trans PF02574.16 PIK58112.1 - 1.6e-10 41.2 0.0 2.7e-10 40.5 0.0 1.3 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Sas6_CC PF18594.1 PIK58112.1 - 0.53 10.1 2.1 7.3 6.5 0.3 2.3 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain S-methyl_trans PF02574.16 PIK58113.1 - 1.2e-44 153.1 0.0 2.1e-44 152.3 0.0 1.3 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Cys_knot PF00007.22 PIK58114.1 - 3.2e-13 49.9 5.8 4.4e-13 49.4 5.8 1.1 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 PIK58114.1 - 0.0029 17.6 4.2 0.0032 17.5 3.3 1.6 1 1 0 1 1 1 1 DAN domain PT PF04886.12 PIK58115.1 - 0.0021 17.6 0.7 1.9 8.1 0.0 3.5 3 1 0 3 3 3 2 PT repeat PAN_1 PF00024.26 PIK58115.1 - 0.17 11.9 0.0 0.46 10.5 0.0 1.7 2 0 0 2 2 2 0 PAN domain Cys_knot PF00007.22 PIK58116.1 - 2.7e-09 37.3 1.1 3.4e-09 36.9 0.8 1.4 1 1 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 PIK58116.1 - 0.0015 18.5 1.0 0.0021 18.1 1.0 1.2 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 PIK58117.1 - 8.8e-08 32.4 9.1 1.5e-07 31.7 9.1 1.4 1 1 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 PIK58117.1 - 1e-07 32.0 5.4 1.5e-07 31.4 5.4 1.2 1 0 0 1 1 1 1 DAN domain Scramblase PF03803.15 PIK58117.1 - 0.023 14.0 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Scramblase TGF_beta PF00019.20 PIK58117.1 - 0.054 14.5 5.7 0.075 14.0 5.7 1.2 1 0 0 1 1 1 0 Transforming growth factor beta like domain tRNA_edit PF04073.15 PIK58118.1 - 4.7e-27 94.5 0.0 5.8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Ank_2 PF12796.7 PIK58119.1 - 8.6e-66 218.5 11.6 1.1e-14 54.7 0.1 4.7 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK58119.1 - 1e-41 140.8 4.6 1.7e-08 34.8 0.0 7.1 3 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 PIK58119.1 - 1.9e-36 122.9 5.9 2.8e-06 27.5 0.0 8.3 7 1 1 8 8 8 8 Ankyrin repeat Ank_5 PF13857.6 PIK58119.1 - 1e-35 121.3 5.7 3.8e-07 30.3 0.0 7.1 3 1 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK58119.1 - 2.9e-32 107.1 1.4 0.0002 21.6 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat DUF2390 PF09523.10 PIK58119.1 - 0.061 13.6 0.1 0.2 12.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) Cyt-b5 PF00173.28 PIK58120.1 - 3.7e-10 39.8 0.1 5.9e-10 39.2 0.1 1.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Actin PF00022.19 PIK58121.1 - 1.1e-55 188.9 0.0 8.3e-51 172.9 0.0 2.1 2 0 0 2 2 2 2 Actin VWC PF00093.18 PIK58122.1 - 2.6e-31 107.7 56.1 3.3e-11 43.3 13.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type C domain TILa PF12714.7 PIK58122.1 - 3e-12 46.3 45.2 0.00016 21.6 8.2 3.7 3 0 0 3 3 3 3 TILa domain CFC PF09443.10 PIK58122.1 - 6.2e-05 22.8 25.2 0.097 12.5 5.2 3.7 3 0 0 3 3 3 3 Cripto_Frl-1_Cryptic (CFC) Amnionless PF14828.6 PIK58122.1 - 0.0014 17.6 17.2 0.0014 17.6 17.2 4.1 3 1 1 4 4 4 3 Amnionless PSP94 PF05825.11 PIK58122.1 - 0.051 14.1 31.5 0.22 12.1 1.2 3.7 2 1 1 3 3 3 0 Beta-microseminoprotein (PSP-94) MFS_1 PF07690.16 PIK58124.1 - 8.6e-24 84.1 29.8 8.6e-24 84.1 29.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 PIK58124.1 - 7.7e-08 31.2 3.6 1.3e-07 30.4 3.6 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector Sugar_tr PF00083.24 PIK58124.1 - 2.5e-05 23.4 13.9 2.5e-05 23.4 13.9 3.8 2 2 1 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 PIK58124.1 - 7.9e-05 21.1 2.0 0.00015 20.2 2.0 1.6 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF4227 PF14004.6 PIK58124.1 - 3.4 7.7 5.0 0.89 9.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) Ribosomal_L4 PF00573.22 PIK58125.1 - 1.8e-14 53.9 0.0 2.3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family TTKRSYEDQ PF10212.9 PIK58126.1 - 4.5e-154 514.3 18.4 4.5e-154 514.3 18.4 2.1 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein KLRAQ PF10205.9 PIK58126.1 - 9e-16 57.9 9.9 9e-16 57.9 9.9 5.1 3 1 1 4 4 4 1 Predicted coiled-coil domain-containing protein Cep57_CLD_2 PF14197.6 PIK58126.1 - 0.0017 18.4 7.4 0.0017 18.4 7.4 5.9 6 2 0 6 6 6 1 Centrosome localisation domain of PPC89 SPATA48 PF15073.6 PIK58126.1 - 0.02 15.2 0.1 0.059 13.7 0.1 1.8 1 0 0 1 1 1 0 Spermatogenesis-associated protein 48 TraC PF07820.12 PIK58126.1 - 1.7 9.1 5.8 0.49 10.8 0.6 2.8 2 1 0 2 2 2 0 TraC-like protein ApoLp-III PF07464.11 PIK58126.1 - 4 7.5 37.1 0.031 14.4 8.7 4.9 5 0 0 5 5 5 0 Apolipophorin-III precursor (apoLp-III) DUF1848 PF08902.11 PIK58126.1 - 5 6.8 9.8 0.11 12.2 1.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1848) DUF2608 PF11019.8 PIK58127.1 - 0.024 14.1 0.2 0.039 13.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) PBS_linker_poly PF00427.21 PIK58127.1 - 0.033 14.2 0.2 0.11 12.5 0.2 1.9 2 0 0 2 2 2 0 Phycobilisome Linker polypeptide AAA_12 PF13087.6 PIK58127.1 - 0.043 13.4 0.3 0.079 12.6 0.3 1.5 1 0 0 1 1 1 0 AAA domain TPD52 PF04201.15 PIK58127.1 - 0.084 12.5 0.6 0.17 11.5 0.6 1.5 1 0 0 1 1 1 0 Tumour protein D52 family Glyco_transf_64 PF09258.10 PIK58128.1 - 3.1e-68 229.7 0.0 4.1e-68 229.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Gtr1_RagA PF04670.12 PIK58129.1 - 1.7e-73 246.8 1.4 2.2e-73 246.5 1.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK58129.1 - 5.5e-05 22.7 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 PIK58129.1 - 0.0002 21.6 0.0 0.0003 21.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK58129.1 - 0.00074 19.0 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK58129.1 - 0.0048 17.0 0.0 0.011 15.8 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 PIK58129.1 - 0.0049 16.5 0.1 0.0077 15.8 0.1 1.3 1 0 0 1 1 1 1 Ras family AAA_14 PF13173.6 PIK58129.1 - 0.099 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 PIK58129.1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Tmemb_cc2 PF10267.9 PIK58130.1 - 2.4e-120 402.4 9.2 3.2e-120 402.0 9.2 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 PIK58130.1 - 0.0045 16.0 5.5 0.012 14.5 0.1 2.1 2 0 0 2 2 2 1 LMBR1-like membrane protein VPS13_C PF16909.5 PIK58130.1 - 0.015 15.0 0.1 0.046 13.5 0.1 1.9 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Fib_alpha PF08702.10 PIK58130.1 - 0.034 14.3 27.4 0.68 10.1 11.9 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 PIK58130.1 - 0.042 13.4 16.8 0.15 11.6 7.0 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit ODV-E18 PF10717.9 PIK58130.1 - 0.062 13.2 0.8 0.18 11.7 0.8 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ATG_C PF09333.11 PIK58130.1 - 0.12 12.7 1.6 12 6.3 0.0 3.9 3 1 1 4 4 4 0 Autophagy-related protein C terminal domain FUSC PF04632.12 PIK58130.1 - 0.51 8.8 2.2 0.78 8.2 2.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prominin PF05478.11 PIK58130.1 - 1.2 7.0 16.1 0.43 8.5 5.6 2.2 2 0 0 2 2 2 0 Prominin Cyclin_C PF02984.19 PIK58130.1 - 2 8.5 5.9 3 8.0 0.1 3.3 2 1 1 3 3 3 0 Cyclin, C-terminal domain DUF1599 PF07659.11 PIK58130.1 - 2.8 8.5 5.6 1 9.8 0.2 3.0 3 0 0 3 3 3 0 Nucleotide modification associated domain 1 HMMR_N PF15905.5 PIK58130.1 - 2.9 7.3 31.1 0.24 10.8 11.9 2.3 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4407 PF14362.6 PIK58130.1 - 6.8 5.9 24.7 3.1 7.0 1.7 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Tweety PF04906.13 PIK58130.1 - 8.7 4.9 13.9 1.2 7.7 0.3 2.9 2 1 1 3 3 3 0 Tweety NACHT PF05729.12 PIK58131.1 - 1e-14 54.8 0.1 2.1e-14 53.8 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 PIK58131.1 - 9.8e-05 22.7 0.0 0.028 14.8 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK58131.1 - 0.00016 22.1 2.8 0.0029 18.0 1.6 2.9 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 PIK58131.1 - 0.00078 18.7 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK58131.1 - 0.0011 19.2 0.0 0.0037 17.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain SRPRB PF09439.10 PIK58131.1 - 0.006 16.0 0.0 0.0096 15.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 PIK58131.1 - 0.0091 15.5 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region G-alpha PF00503.20 PIK58131.1 - 0.01 15.0 0.1 0.019 14.1 0.0 1.8 1 1 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 PIK58131.1 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ThiF PF00899.21 PIK58131.1 - 0.013 14.9 0.0 0.18 11.1 0.0 2.5 2 1 0 2 2 2 0 ThiF family AAA_25 PF13481.6 PIK58131.1 - 0.014 15.0 0.0 0.035 13.7 0.0 1.6 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 PIK58131.1 - 0.016 14.6 0.0 0.038 13.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 PIK58131.1 - 0.016 14.9 0.0 0.039 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 PIK58131.1 - 0.023 14.9 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 PIK58131.1 - 0.024 14.4 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 PIK58131.1 - 0.026 13.9 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ras PF00071.22 PIK58131.1 - 0.029 13.9 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Ras family TrwB_AAD_bind PF10412.9 PIK58131.1 - 0.036 13.0 0.0 0.063 12.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 PIK58131.1 - 0.075 12.1 0.0 0.19 10.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 PIK58131.1 - 0.077 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 PIK58131.1 - 0.084 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 PIK58131.1 - 0.089 12.1 0.0 0.24 10.7 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 PIK58131.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 PIK58131.1 - 0.14 12.3 0.0 0.48 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 PIK58131.1 - 0.16 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin SRP54 PF00448.22 PIK58131.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 PIK58132.1 - 2.1e-14 53.8 0.1 4.1e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 PIK58132.1 - 0.00022 21.6 0.0 0.046 14.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK58132.1 - 0.00038 20.9 1.3 0.0043 17.5 1.3 2.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK58132.1 - 0.0014 17.8 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK58132.1 - 0.0019 18.5 0.0 0.0064 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.10 PIK58132.1 - 0.0073 15.7 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 PIK58132.1 - 0.017 14.9 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 PIK58132.1 - 0.02 14.1 0.0 0.11 11.7 0.0 1.9 1 1 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 PIK58132.1 - 0.025 14.1 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 PIK58132.1 - 0.025 14.3 0.0 0.064 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 PIK58132.1 - 0.037 13.4 0.0 0.075 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 PIK58132.1 - 0.037 14.2 0.0 0.082 13.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 PIK58132.1 - 0.037 13.8 0.0 0.081 12.7 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ThiF PF00899.21 PIK58132.1 - 0.041 13.2 0.0 0.37 10.1 0.0 2.4 2 1 0 2 2 2 0 ThiF family AAA PF00004.29 PIK58132.1 - 0.041 14.3 0.0 1.1 9.7 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 PIK58132.1 - 0.05 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 PIK58132.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 PIK58132.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family FTH PF01827.27 PIK58132.1 - 0.089 12.6 0.2 9.5 6.0 0.0 2.5 2 0 0 2 2 2 0 FTH domain AAA_33 PF13671.6 PIK58132.1 - 0.11 12.6 0.0 0.75 9.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 PIK58132.1 - 0.12 11.4 0.0 0.38 9.8 0.0 1.8 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 PIK58132.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 PIK58132.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2972 PF11186.8 PIK58133.1 - 0.037 13.9 0.3 0.039 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) Trypsin PF00089.26 PIK58134.1 - 2.9e-55 187.5 0.6 4.7e-55 186.8 0.1 1.6 2 0 0 2 2 2 1 Trypsin HYR PF02494.16 PIK58134.1 - 1.3e-33 115.2 25.6 7.5e-15 55.0 1.0 4.8 4 0 0 4 4 4 4 HYR domain SEA PF01390.20 PIK58134.1 - 2.9e-05 24.1 0.0 8.2e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 SEA domain CUB PF00431.20 PIK58134.1 - 0.0011 19.3 0.0 0.0036 17.6 0.0 1.9 1 0 0 1 1 1 1 CUB domain DUF1986 PF09342.11 PIK58134.1 - 0.0014 19.0 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) RL10P_insert PF17777.1 PIK58135.1 - 1.2e-26 92.5 0.0 1.9e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 PIK58135.1 - 3.8e-18 65.5 0.3 5.5e-18 65.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 14-3-3 PF00244.20 PIK58136.1 - 3.4e-105 350.4 6.4 3.9e-105 350.3 6.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Focal_AT PF03623.13 PIK58136.1 - 0.06 13.3 1.1 2.7 8.0 0.3 2.3 2 0 0 2 2 2 0 Focal adhesion targeting region Laminin_G_1 PF00054.23 PIK58137.1 - 8.7e-18 64.8 0.0 1.1e-17 64.5 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 PIK58137.1 - 8.7e-18 65.1 0.1 1.1e-17 64.7 0.1 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 PIK58138.1 - 5.4e-09 36.7 0.0 8.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK58138.1 - 1.3e-06 28.7 0.0 3.1e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Laminin G domain EGF PF00008.27 PIK58138.1 - 7.2e-06 26.2 14.7 0.00027 21.1 3.7 3.2 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 PIK58138.1 - 0.028 15.1 2.4 0.028 15.1 2.4 3.4 4 0 0 4 4 4 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK58138.1 - 0.62 10.5 19.0 0.078 13.4 6.5 2.8 2 0 0 2 2 2 0 EGF-like domain EGF PF00008.27 PIK58139.1 - 4.4e-77 253.9 178.6 1.4e-09 38.1 5.3 13.8 14 0 0 14 14 14 13 EGF-like domain hEGF PF12661.7 PIK58139.1 - 1.8e-42 142.5 155.2 2.8e-06 27.7 3.3 15.0 14 1 0 14 14 14 13 Human growth factor-like EGF EGF_2 PF07974.13 PIK58139.1 - 1.5e-13 50.9 198.9 0.0012 19.2 7.4 13.7 13 0 0 13 13 13 11 EGF-like domain EGF_CA PF07645.15 PIK58139.1 - 7.1e-09 35.7 191.8 0.00014 21.9 5.6 13.3 8 2 5 13 13 13 9 Calcium-binding EGF domain EGF_3 PF12947.7 PIK58139.1 - 0.00066 19.8 157.9 0.023 14.9 3.8 14.1 8 3 5 13 13 13 8 EGF domain Plasmod_Pvs28 PF06247.11 PIK58139.1 - 0.02 15.2 4.0 0.02 15.2 4.0 11.4 12 0 0 12 12 12 0 Pvs28 EGF domain UBX PF00789.20 PIK58140.1 - 2.5e-12 46.8 0.0 1.1e-11 44.8 0.0 2.1 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 PIK58140.1 - 5.2e-06 26.2 0.0 1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 PIK58140.1 - 3.1e-05 24.1 0.0 8.9e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like RcsD_ABL PF16359.5 PIK58140.1 - 0.022 14.9 0.2 0.26 11.4 0.3 2.3 2 0 0 2 2 2 0 RcsD-ABL domain Presenilin PF01080.17 PIK58140.1 - 1.9 7.2 3.9 3 6.5 3.9 1.3 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 PIK58140.1 - 1.9 9.1 8.8 0.26 11.9 0.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TRP_2 PF08344.11 PIK58141.1 - 1.4e-27 95.7 0.7 2.8e-27 94.7 0.7 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 PIK58141.1 - 6.2e-06 25.6 0.4 6.2e-06 25.6 0.4 1.5 2 0 0 2 2 2 1 Ion transport protein Ank_5 PF13857.6 PIK58141.1 - 0.00023 21.4 0.1 0.01 16.1 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK58141.1 - 0.0013 19.1 0.0 0.072 13.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 PIK58141.1 - 0.0038 17.8 0.0 0.016 15.8 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK58141.1 - 0.01 16.3 0.1 0.12 13.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat DUF3687 PF12459.8 PIK58141.1 - 0.084 12.4 0.4 0.32 10.6 0.4 2.0 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein DUF4698 PF15769.5 PIK58142.1 - 3.5e-37 128.6 16.8 4.1e-37 128.4 16.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4698) HTH_34 PF13601.6 PIK58142.1 - 0.018 15.2 0.7 0.51 10.6 0.0 2.8 3 0 0 3 3 3 0 Winged helix DNA-binding domain Reprolysin_2 PF13574.6 PIK58143.1 - 6.4e-32 111.0 0.0 1.8e-31 109.6 0.0 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK58143.1 - 4.4e-31 108.6 0.0 4.4e-31 108.6 0.0 2.4 3 0 0 3 3 3 1 Metallo-peptidase family M12 Disintegrin PF00200.23 PIK58143.1 - 9.9e-14 51.9 26.2 9.9e-14 51.9 26.2 3.0 3 1 1 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 PIK58143.1 - 6.6e-13 49.3 0.1 1.9e-12 47.8 0.0 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 PIK58143.1 - 3.8e-10 40.1 0.2 1e-09 38.7 0.2 1.7 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM17_MPD PF16698.5 PIK58143.1 - 1.4e-08 35.0 11.3 1.4e-08 35.0 11.3 3.7 2 1 0 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 Reprolysin_4 PF13583.6 PIK58143.1 - 1.9e-06 27.6 0.1 3.2e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 PIK58143.1 - 2.3e-06 27.7 0.0 0.0012 18.8 0.0 3.0 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease TPR_1 PF00515.28 PIK58144.1 - 1.7e-37 125.7 16.8 2e-06 27.3 0.6 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 PIK58144.1 - 1.1e-31 106.4 14.3 0.003 17.5 0.4 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 PIK58144.1 - 3.3e-20 70.5 16.2 0.0063 16.6 0.0 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_9 PF13371.6 PIK58144.1 - 1.5e-17 63.5 0.0 0.0018 18.4 0.0 6.3 4 2 2 6 6 6 5 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 PIK58144.1 - 3.8e-13 49.3 17.5 1.2e-05 25.3 0.1 7.3 8 0 0 8 8 8 3 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 PIK58144.1 - 2.2e-12 46.4 18.6 1.6e-05 24.5 0.0 7.2 5 4 5 10 10 10 4 TPR repeat TPR_17 PF13431.6 PIK58144.1 - 2.3e-11 43.2 9.2 0.00092 19.4 0.1 7.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK58144.1 - 1.1e-08 35.2 15.6 0.29 11.5 0.4 7.1 3 3 4 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK58144.1 - 1.4e-08 35.1 6.9 0.00066 20.1 0.1 5.1 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK58144.1 - 1.8e-08 34.9 1.0 0.23 12.1 0.0 5.5 4 3 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK58144.1 - 7.6e-08 31.9 14.4 2.2 8.5 0.0 7.7 8 2 0 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK58144.1 - 9.6e-06 26.0 4.2 3.7 8.6 0.0 6.7 5 2 4 9 9 8 1 Tetratricopeptide repeat MIT PF04212.18 PIK58144.1 - 0.0024 17.9 14.9 5.4 7.2 0.0 6.5 6 0 0 6 6 6 1 MIT (microtubule interacting and transport) domain RPAP3_C PF13877.6 PIK58144.1 - 0.0068 16.9 0.1 0.041 14.4 0.0 2.3 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_6 PF13174.6 PIK58144.1 - 0.11 13.1 13.1 22 6.0 0.0 7.0 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 PIK58144.1 - 1.2 9.2 5.0 62 3.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat NKAIN PF05640.14 PIK58145.1 - 1.4e-54 184.5 11.4 1.9e-54 184.1 11.4 1.1 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Linker_histone PF00538.19 PIK58146.1 - 8.6e-21 74.1 0.7 8.6e-21 74.1 0.7 3.0 2 1 0 2 2 1 1 linker histone H1 and H5 family DUF5521 PF17659.1 PIK58146.1 - 0.041 11.8 12.4 0.049 11.5 12.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) SLC12 PF03522.15 PIK58146.1 - 0.06 12.4 12.8 0.072 12.1 12.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 PIK58146.1 - 0.15 10.7 12.5 0.16 10.6 12.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Asp-B-Hydro_N PF05279.11 PIK58146.1 - 0.18 11.8 12.5 0.22 11.5 12.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF2052 PF09747.9 PIK58146.1 - 0.2 11.7 8.2 0.3 11.2 8.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) GREB1 PF15782.5 PIK58146.1 - 0.44 7.6 11.1 0.45 7.6 11.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pkinase_fungal PF17667.1 PIK58146.1 - 0.44 9.3 11.2 0.55 8.9 11.2 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF2486 PF10667.9 PIK58146.1 - 0.52 10.5 11.8 0.79 9.9 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) LMBR1 PF04791.16 PIK58146.1 - 1.1 8.1 5.3 1.2 8.0 5.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 PIK58146.1 - 1.2 8.9 18.0 1.8 8.3 18.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Membralin PF09746.9 PIK58146.1 - 1.5 7.7 6.7 2 7.4 6.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein CDC45 PF02724.14 PIK58146.1 - 2.8 6.1 12.9 3.5 5.8 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 PIK58146.1 - 2.9 8.0 29.9 5.1 7.2 29.9 1.4 1 0 0 1 1 1 0 YL1 nuclear protein DUF4551 PF15087.6 PIK58146.1 - 3.6 6.3 13.1 4.1 6.1 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3807 PF12720.7 PIK58146.1 - 3.9 7.7 23.3 7.2 6.8 23.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Hid1 PF12722.7 PIK58146.1 - 4.3 5.3 13.3 5.4 5.0 13.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Borrelia_P83 PF05262.11 PIK58146.1 - 5.2 5.4 25.1 6.4 5.2 25.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 PIK58146.1 - 6.3 5.5 14.7 8 5.1 14.7 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 PIK58146.1 - 9.5 4.9 9.9 11 4.7 9.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CRAL_TRIO_N PF03765.15 PIK58147.1 - 6.6e-06 26.2 2.2 1.2e-05 25.4 2.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO PF00650.20 PIK58148.1 - 1.3e-11 44.5 0.0 1.7e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain LRR_8 PF13855.6 PIK58149.1 - 0.00018 21.2 19.7 0.51 10.1 1.9 4.8 2 2 2 4 4 4 4 Leucine rich repeat Ig_2 PF13895.6 PIK58149.1 - 0.0018 18.6 0.1 0.0087 16.4 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRRCT PF01463.24 PIK58149.1 - 0.012 16.1 2.7 0.056 14.0 0.4 2.6 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain EPL1 PF10513.9 PIK58149.1 - 0.054 13.9 0.2 0.093 13.1 0.2 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Ig_3 PF13927.6 PIK58149.1 - 0.27 11.9 1.4 0.89 10.2 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin domain LRR_9 PF14580.6 PIK58149.1 - 0.41 10.1 7.1 0.28 10.6 1.8 2.6 2 1 1 3 3 3 0 Leucine-rich repeat LRR_8 PF13855.6 PIK58150.1 - 0.00016 21.4 15.2 0.7 9.7 0.6 5.2 4 2 1 5 5 5 3 Leucine rich repeat Oxidored_q2 PF00420.24 PIK58150.1 - 0.0022 17.6 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Ig_2 PF13895.6 PIK58150.1 - 0.0055 17.0 0.4 0.02 15.2 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK58150.1 - 0.013 15.9 0.1 0.051 14.0 0.0 2.0 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_9 PF14580.6 PIK58150.1 - 0.035 13.6 4.8 0.55 9.7 1.8 2.7 1 1 0 2 2 2 0 Leucine-rich repeat Ig_3 PF13927.6 PIK58150.1 - 0.043 14.4 0.2 0.043 14.4 0.2 2.3 2 0 0 2 2 2 0 Immunoglobulin domain LRR_4 PF12799.7 PIK58150.1 - 0.19 12.2 0.1 0.19 12.2 0.1 5.4 6 1 0 6 6 6 0 Leucine Rich repeats (2 copies) M-factor PF03855.13 PIK58151.1 - 0.28 11.4 1.5 0.73 10.0 0.1 2.2 2 0 0 2 2 2 0 M-factor PH PF00169.29 PIK58152.1 - 4e-43 146.2 1.5 2.6e-20 72.9 0.1 3.5 3 1 1 4 4 4 2 PH domain PDZ PF00595.24 PIK58152.1 - 2.4e-14 53.5 0.2 4.1e-14 52.7 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 PIK58152.1 - 6.9e-13 48.9 11.2 9.1e-06 26.0 3.8 3.6 2 2 0 2 2 2 2 Pleckstrin homology domain PDZ_6 PF17820.1 PIK58152.1 - 3.2e-09 36.5 0.7 6.1e-09 35.6 0.7 1.4 1 0 0 1 1 1 1 PDZ domain PH_9 PF15410.6 PIK58152.1 - 4.6e-08 33.4 5.3 0.016 15.6 0.2 4.1 2 2 0 2 2 2 2 Pleckstrin homology domain PDZ_2 PF13180.6 PIK58152.1 - 1.5e-06 28.5 0.1 3.5e-06 27.2 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PH_3 PF14593.6 PIK58152.1 - 2.6e-06 27.5 0.8 3.4e-05 23.9 0.2 2.4 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 PIK58152.1 - 5.3e-06 26.6 5.2 0.0064 16.7 0.2 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 PIK58152.1 - 4.8e-05 23.2 0.2 0.042 13.7 0.1 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_15 PF17339.2 PIK58152.1 - 0.00011 22.1 1.5 0.32 10.9 0.3 2.7 2 1 0 2 2 2 2 PH domain PH_16 PF17838.1 PIK58152.1 - 0.0023 17.8 0.0 0.5 10.2 0.1 2.7 2 1 0 2 2 2 1 PH domain PH_6 PF15406.6 PIK58152.1 - 0.009 16.3 0.0 0.68 10.2 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain DUF1560 PF07597.11 PIK58153.1 - 0.047 13.7 14.4 77 3.4 0.1 7.1 6 3 2 8 8 8 0 Protein of unknown function (DUF1560) DNA_ligase_OB PF03120.16 PIK58153.1 - 0.064 13.1 5.6 4.6 7.2 0.2 3.7 1 1 3 4 4 4 0 NAD-dependent DNA ligase OB-fold domain DUF5602 PF18197.1 PIK58153.1 - 0.14 12.6 1.7 8.2 7.0 0.0 4.2 3 3 4 7 7 7 0 Domain of unknown function (DUF5602) MFS_1 PF07690.16 PIK58154.1 - 7e-41 140.3 42.6 1.3e-32 113.1 37.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK58154.1 - 0.00015 20.8 25.2 0.014 14.3 0.6 4.1 2 2 1 4 4 4 3 MFS_1 like family Nodulin-like PF06813.13 PIK58154.1 - 0.00061 19.3 3.2 0.00061 19.3 3.2 2.1 2 0 0 2 2 2 1 Nodulin-like UPF0060 PF02694.15 PIK58154.1 - 0.0084 16.3 6.6 0.22 11.8 0.2 3.6 3 1 0 3 3 3 2 Uncharacterised BCR, YnfA/UPF0060 family PfkB PF00294.24 PIK58155.1 - 3.5e-07 29.8 0.0 1.7e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Indigoidine_A PF04227.12 PIK58156.1 - 3.3e-103 345.0 0.5 4.5e-103 344.6 0.5 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 PIK58156.1 - 1.4e-15 57.4 0.0 2.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase LRR_8 PF13855.6 PIK58158.1 - 3.8e-38 129.1 20.3 2.6e-16 59.1 0.1 3.7 2 1 2 4 4 4 3 Leucine rich repeat LRR_5 PF13306.6 PIK58158.1 - 1.3e-18 67.2 3.0 4.7e-10 39.5 0.2 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) 7tm_1 PF00001.21 PIK58158.1 - 7.9e-18 64.7 3.7 1.1e-17 64.2 3.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_4 PF12799.7 PIK58158.1 - 1.2e-13 51.0 29.6 1.5e-06 28.5 0.2 4.3 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK58158.1 - 2e-09 36.7 15.7 0.53 11.0 0.1 6.3 5 1 0 5 5 5 4 Leucine Rich Repeat LRR_9 PF14580.6 PIK58158.1 - 1e-05 25.1 6.4 0.00015 21.3 3.1 2.4 1 1 1 2 2 2 1 Leucine-rich repeat Git3 PF11710.8 PIK58158.1 - 0.0036 17.1 3.6 0.0057 16.4 3.6 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srx PF10328.9 PIK58158.1 - 0.023 14.3 6.0 0.043 13.5 6.0 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Srg PF02118.21 PIK58158.1 - 0.048 13.3 4.2 0.075 12.7 4.2 1.3 1 0 0 1 1 1 0 Srg family chemoreceptor Serpentine_r_xa PF03383.15 PIK58158.1 - 0.049 13.6 1.1 0.097 12.7 1.1 1.5 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa LRR_6 PF13516.6 PIK58158.1 - 0.2 11.8 16.3 3.3 8.0 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich repeat DOMON PF03351.17 PIK58159.1 - 4.1e-11 43.2 0.1 7.1e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 PIK58159.1 - 0.2 11.8 6.1 1.3 9.2 6.1 2.2 1 1 0 1 1 1 0 Eukaryotic cytochrome b561 WD40 PF00400.32 PIK58160.1 - 1.4e-21 76.4 10.1 7.4e-07 29.8 0.1 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58160.1 - 4.3e-10 39.8 0.2 0.32 11.3 0.1 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK58160.1 - 0.015 15.1 0.0 0.21 11.5 0.0 2.7 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 PIK58160.1 - 0.02 13.4 0.3 3.2 6.2 0.0 3.4 2 1 2 4 4 4 0 Cytochrome D1 heme domain WD40_like PF17005.5 PIK58160.1 - 0.038 13.3 0.1 0.11 11.8 0.0 1.7 2 0 0 2 2 2 0 WD40-like domain MIG-14_Wnt-bd PF06664.12 PIK58161.1 - 1.3e-78 264.2 21.8 1.6e-78 263.9 21.8 1.1 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion Claudin_3 PF06653.11 PIK58161.1 - 0.00091 19.2 7.0 0.00091 19.2 7.0 2.2 2 1 0 2 2 2 1 Tight junction protein, Claudin-like DUF2516 PF10724.9 PIK58161.1 - 3.8 7.8 6.7 2.4 8.5 2.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2516) RAMPs PF03787.15 PIK58162.1 - 0.0029 17.7 34.9 1.5 8.8 0.8 6.0 6 0 0 6 6 6 5 RAMP superfamily DUF3665 PF12427.8 PIK58162.1 - 0.015 14.9 4.6 2.1 8.1 0.2 2.8 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase Inhibitor_I66 PF16850.5 PIK58162.1 - 0.018 14.9 0.4 8.8 6.2 0.0 2.8 3 0 0 3 3 3 0 Peptidase inhibitor I66 zf-H2C2_2 PF13465.6 PIK58163.1 - 7.6e-11 41.9 10.5 2e-06 28.0 0.1 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58163.1 - 3.8e-10 39.7 10.8 7e-06 26.2 0.7 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58163.1 - 4.5e-06 27.0 13.7 6.9e-05 23.4 0.5 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK58163.1 - 2.6e-05 24.1 0.2 2.6e-05 24.1 0.2 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK58163.1 - 4.7e-05 23.6 0.4 0.00032 20.9 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK58163.1 - 7.7e-05 23.0 0.8 0.00018 21.8 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK58163.1 - 0.076 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Phage_CRI PF05144.14 PIK58163.1 - 0.21 10.9 0.7 0.44 9.8 0.5 1.6 2 0 0 2 2 2 0 Phage replication protein CRI FANCL_C PF11793.8 PIK58163.1 - 0.24 11.6 1.5 0.54 10.5 1.5 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain HABP4_PAI-RBP1 PF04774.15 PIK58164.1 - 3e-27 95.8 17.8 3e-27 95.8 17.8 3.7 3 1 1 4 4 4 1 Hyaluronan / mRNA binding family IF-2B PF01008.17 PIK58165.1 - 1.4e-58 198.3 0.2 3e-35 121.8 0.2 2.2 2 0 0 2 2 2 2 Initiation factor 2 subunit family Capsid_VP7 PF17071.5 PIK58165.1 - 0.00081 18.8 0.0 0.0012 18.2 0.0 1.1 1 0 0 1 1 1 1 Outer capsid protein VP7 QSOX_Trx1 PF18108.1 PIK58165.1 - 0.11 12.7 0.0 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 QSOX Trx-like domain tRNA-synt_2b PF00587.25 PIK58166.1 - 1.6e-34 119.5 0.0 2.2e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 PIK58166.1 - 7.8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Adap_comp_sub PF00928.21 PIK58167.1 - 1.2e-93 313.4 1.1 1.4e-93 313.1 1.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK58167.1 - 7.6e-05 22.7 0.2 0.00015 21.7 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 PIK58167.1 - 0.022 14.2 0.4 0.039 13.4 0.0 1.5 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain TP_methylase PF00590.20 PIK58168.1 - 2.2e-25 89.8 0.0 4e-25 89.0 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Cation_efflux PF01545.21 PIK58169.1 - 1.3e-39 136.0 24.2 3e-39 134.8 24.2 1.6 1 1 0 1 1 1 1 Cation efflux family Wzy_C PF04932.15 PIK58169.1 - 3.1 7.4 6.9 1.6e+02 1.9 0.0 2.7 2 1 0 2 2 2 0 O-Antigen ligase NAD_kinase PF01513.21 PIK58170.1 - 1.5e-09 37.5 0.0 0.00037 19.8 0.0 2.1 2 0 0 2 2 2 2 ATP-NAD kinase Alpha_L_fucos PF01120.17 PIK58170.1 - 0.16 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Alpha-L-fucosidase DAGK_cat PF00781.24 PIK58170.1 - 0.19 11.4 0.0 0.58 9.8 0.0 1.8 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Pkinase PF00069.25 PIK58171.1 - 1.9e-66 224.1 0.0 3e-66 223.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58171.1 - 4.6e-41 140.8 0.0 7.8e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-RING_2 PF13639.6 PIK58171.1 - 5e-06 26.7 10.3 5e-06 26.7 10.3 2.5 2 0 0 2 2 2 1 Ring finger domain Kinase-like PF14531.6 PIK58171.1 - 2.9e-05 23.5 0.1 0.28 10.4 0.0 2.5 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 PIK58171.1 - 0.00024 20.0 7.5 0.00024 20.0 7.5 2.3 2 1 0 2 2 2 1 Fungal protein kinase zf-ANAPC11 PF12861.7 PIK58171.1 - 0.011 15.8 5.6 0.035 14.1 5.6 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 PIK58171.1 - 0.012 15.5 9.8 0.012 15.5 9.8 2.7 3 0 0 3 3 3 0 PHD-finger Ribonuc_red_lgC PF02867.15 PIK58171.1 - 0.041 12.4 0.0 0.061 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain APH PF01636.23 PIK58171.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-C6H2 PF15801.5 PIK58171.1 - 5.2 7.4 9.7 29 5.1 1.0 2.8 1 1 1 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding HEXIM PF15313.6 PIK58171.1 - 9.8 6.4 11.4 3.4 7.9 7.9 2.0 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein zf-HC5HC2H_2 PF13832.6 PIK58172.1 - 9.6e-30 103.0 9.3 9.6e-30 103.0 9.3 2.9 3 0 0 3 3 3 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 PIK58172.1 - 5.3e-17 61.2 5.7 3e-10 39.6 0.1 2.7 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 PIK58172.1 - 1.9e-15 56.9 4.7 1.9e-15 56.9 4.7 4.3 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 PIK58172.1 - 1.3e-14 53.4 10.0 1.2e-13 50.4 2.4 3.2 2 0 0 2 2 2 2 PHD-finger PHD PF00628.29 PIK58172.1 - 0.00025 20.8 5.5 0.00025 20.8 5.5 3.7 4 2 0 4 4 4 2 PHD-finger DUF4537 PF15057.6 PIK58172.1 - 0.0078 16.2 0.5 0.023 14.7 0.3 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 PIK58172.1 - 0.0078 16.0 1.3 1.4 8.8 0.0 3.1 2 1 1 3 3 3 1 DNA repair protein Crb2 Tudor domain C1_1 PF00130.22 PIK58172.1 - 0.019 14.8 0.1 0.019 14.8 0.1 4.3 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) JmjC PF02373.22 PIK58173.1 - 5.3e-41 139.6 0.2 5.3e-41 139.6 0.2 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 PIK58173.1 - 4.8e-12 45.6 0.9 1.2e-11 44.3 0.0 2.2 2 0 0 2 2 2 1 jmjN domain Alpha-amylase PF00128.24 PIK58174.1 - 2e-12 47.4 0.0 4.5e-12 46.2 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 PIK58174.1 - 2.3e-06 28.0 0.0 7.1e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 PIK58176.1 - 1.3e-13 51.3 0.0 1.6e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Y_phosphatase PF00102.27 PIK58177.1 - 2.3e-107 357.9 7.1 3.8e-67 226.3 2.4 3.0 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 PIK58177.1 - 2.6e-11 43.5 0.1 2e-07 30.9 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK58177.1 - 2e-09 37.8 0.0 5.7e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 PIK58177.1 - 1.5e-07 31.7 0.1 1.3e-05 25.4 0.1 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 PIK58177.1 - 0.0007 19.2 0.2 0.28 10.7 0.1 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family GTP_EFTU PF00009.27 PIK58177.1 - 0.0026 17.3 0.2 0.047 13.2 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain CDKN3 PF05706.12 PIK58177.1 - 0.0068 16.1 0.0 3.7 7.2 0.0 2.5 2 1 0 2 2 2 2 Cyclin-dependent kinase inhibitor 3 (CDKN3) Myotub-related PF06602.14 PIK58177.1 - 0.012 14.5 0.1 0.28 10.1 0.0 2.2 2 0 0 2 2 2 0 Myotubularin-like phosphatase domain fn3 PF00041.21 PIK58178.1 - 6.6e-19 68.0 0.3 3.2e-08 33.8 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK58178.1 - 3.4e-05 24.3 0.8 0.0088 16.6 0.1 2.7 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 PIK58178.1 - 0.00044 20.1 0.0 0.078 12.9 0.0 2.4 2 0 0 2 2 2 2 Fibronectin-III type domain fn3_2 PF16893.5 PIK58178.1 - 0.0075 16.4 0.2 0.053 13.7 0.0 2.2 2 1 0 2 2 2 1 Fibronectin type III domain fn3 PF00041.21 PIK58179.1 - 9.2e-10 38.7 0.1 4.6e-06 26.9 0.1 3.0 3 0 0 3 3 3 2 Fibronectin type III domain GIY-YIG PF01541.24 PIK58179.1 - 0.0078 16.5 0.1 0.018 15.3 0.1 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain EGF PF00008.27 PIK58180.1 - 0.0041 17.4 8.0 0.0041 17.4 8.0 8.6 5 4 1 6 6 6 2 EGF-like domain hEGF PF12661.7 PIK58180.1 - 0.0068 17.0 7.6 0.0068 17.0 7.6 10.0 7 2 2 9 9 9 1 Human growth factor-like EGF Y_phosphatase PF00102.27 PIK58182.1 - 6.9e-77 258.2 6.8 2.9e-53 180.8 1.2 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 PIK58182.1 - 0.071 13.2 0.0 0.24 11.5 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate HTH_38 PF13936.6 PIK58183.1 - 0.015 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 PIK58183.1 - 0.032 14.4 0.2 0.12 12.5 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_7 PF02796.15 PIK58183.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase EspA PF03433.13 PIK58183.1 - 0.19 11.6 0.0 0.42 10.4 0.0 1.5 2 0 0 2 2 2 0 EspA-like secreted protein Dimer_Tnp_hAT PF05699.14 PIK58184.1 - 3.2e-07 30.0 2.1 5.8e-07 29.2 1.0 2.0 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Nup54_C PF18437.1 PIK58184.1 - 0.85 9.6 3.4 0.85 9.6 0.1 2.6 3 0 0 3 3 3 0 Nup54 C-terminal interacting domain RT_RNaseH_2 PF17919.1 PIK58185.1 - 2.3e-37 127.0 0.1 5e-37 125.9 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58185.1 - 1.4e-33 115.4 0.1 2.7e-33 114.4 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58185.1 - 4.3e-31 108.2 0.0 6.7e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK58186.1 - 1.1e-22 80.4 0.0 1.8e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-C2H2 PF00096.26 PIK58186.1 - 1.2e-06 28.6 11.1 0.00066 20.0 2.1 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK58186.1 - 0.00016 21.4 2.3 0.00016 21.4 2.3 3.1 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 PIK58186.1 - 0.00023 21.7 8.4 0.0085 16.9 1.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 PIK58186.1 - 0.0012 18.4 1.3 0.89 9.2 0.2 2.4 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-Di19 PF05605.12 PIK58186.1 - 0.0023 18.2 0.8 0.0051 17.1 0.8 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding rve_3 PF13683.6 PIK58186.1 - 0.0048 16.7 0.0 0.013 15.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2_2 PF13465.6 PIK58186.1 - 0.014 15.8 0.8 0.014 15.8 0.8 3.2 3 0 0 3 3 3 0 Zinc-finger double domain MycE_N PF17843.1 PIK58186.1 - 0.025 15.1 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal zf-C2H2_11 PF16622.5 PIK58186.1 - 0.028 14.2 1.6 0.047 13.5 0.1 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 PIK58186.1 - 0.2 11.7 4.7 0.59 10.2 4.7 1.9 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Actin_micro PF17003.5 PIK58186.1 - 1.8 7.7 5.3 1.9 7.5 0.6 2.4 2 1 1 3 3 3 0 Putative actin-like family zf-C2H2_jaz PF12171.8 PIK58186.1 - 6.1 7.3 12.3 6.7 7.1 1.4 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Y_phosphatase PF00102.27 PIK58187.1 - 6.4e-31 107.7 0.2 7.9e-31 107.4 0.2 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase PF00102.27 PIK58189.1 - 7.6e-21 74.7 1.7 3e-20 72.8 1.7 1.9 1 1 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK58189.1 - 1.7e-08 34.7 5.4 6.7e-08 32.8 1.0 2.8 2 0 0 2 2 2 1 Fibronectin type III domain fn3_4 PF16794.5 PIK58189.1 - 0.0059 16.5 0.4 0.059 13.3 0.2 2.2 1 1 1 2 2 2 1 Fibronectin-III type domain Y_phosphatase PF00102.27 PIK58191.1 - 9.5e-25 87.5 1.3 1.6e-15 57.3 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase PF00102.27 PIK58192.1 - 4.2e-14 52.7 0.1 4.9e-14 52.5 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rrp15p PF07890.12 PIK58192.1 - 0.13 12.6 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 Rrp15p Alg6_Alg8 PF03155.15 PIK58193.1 - 1.3e-108 364.0 5.3 1.5e-108 363.8 5.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family RcsF PF16358.5 PIK58194.1 - 0.035 14.2 0.0 0.09 12.8 0.0 1.7 1 0 0 1 1 1 0 RcsF lipoprotein zf-H2C2_2 PF13465.6 PIK58195.1 - 1.7e-11 44.0 9.4 1.6e-06 28.3 0.1 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58195.1 - 2.2e-10 40.4 10.8 5.6e-06 26.5 0.7 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58195.1 - 2.6e-06 27.8 13.7 5.5e-05 23.7 0.5 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK58195.1 - 2.1e-05 24.4 0.2 2.1e-05 24.4 0.2 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK58195.1 - 3.2e-05 24.1 0.4 0.00026 21.2 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK58195.1 - 5.7e-05 23.4 0.8 0.00014 22.1 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK58195.1 - 0.057 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) FANCL_C PF11793.8 PIK58195.1 - 0.22 11.7 1.8 0.49 10.6 1.8 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain Alg6_Alg8 PF03155.15 PIK58196.1 - 9e-75 252.5 18.9 1.1e-74 252.2 18.9 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF2614 PF11023.8 PIK58196.1 - 2.2 8.4 5.7 0.6 10.2 1.4 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain Asn_synthase PF00733.21 PIK58197.1 - 2.1e-18 67.1 0.4 4.4e-07 29.9 0.0 3.4 3 1 1 4 4 4 3 Asparagine synthase GATase_7 PF13537.6 PIK58197.1 - 1e-07 31.9 0.0 7e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 PIK58197.1 - 0.00073 19.7 0.0 0.0023 18.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain FBPase_glpX PF03320.13 PIK58197.1 - 0.046 12.6 0.2 0.069 12.0 0.2 1.1 1 0 0 1 1 1 0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded Stevor PF17410.2 PIK58198.1 - 0.051 13.1 4.1 0.51 9.8 1.0 2.2 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Shisa PF13908.6 PIK58198.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Adeno_E3_CR2 PF02439.15 PIK58198.1 - 0.43 10.4 4.0 0.77 9.6 4.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF2368 PF10166.9 PIK58199.1 - 1e-45 154.6 0.8 1.3e-45 154.3 0.8 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) DUF2206 PF09971.9 PIK58200.1 - 0.097 11.4 0.5 0.18 10.5 0.0 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) C1_1 PF00130.22 PIK58201.1 - 2.6e-12 46.4 16.2 3.8e-07 29.9 9.8 2.7 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_1 PF00536.30 PIK58201.1 - 6e-11 42.6 0.1 1.3e-10 41.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK58201.1 - 4.9e-09 36.2 0.2 1.3e-08 34.8 0.1 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 PIK58201.1 - 0.0052 16.4 0.6 0.26 10.9 0.1 2.4 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 PIK58201.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain PHD PF00628.29 PIK58201.1 - 8.4 6.4 13.7 1.7 8.6 5.6 3.4 4 0 0 4 4 4 0 PHD-finger Gaa1 PF04114.14 PIK58202.1 - 9.3e-101 338.3 0.0 1.8e-100 337.4 0.0 1.4 2 0 0 2 2 2 1 Gaa1-like, GPI transamidase component MIEAP PF16026.5 PIK58203.1 - 2.2e-38 132.5 0.4 5.3e-38 131.2 0.0 1.8 1 1 0 1 1 1 1 Mitochondria-eating protein HAUS6_N PF14661.6 PIK58203.1 - 0.004 16.8 4.7 0.01 15.4 3.7 1.9 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus Zwint PF15556.6 PIK58203.1 - 0.014 14.9 5.2 0.027 14.0 5.2 1.4 1 0 0 1 1 1 0 ZW10 interactor CorA PF01544.18 PIK58203.1 - 0.074 12.4 4.1 0.11 11.8 4.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TipAS PF07739.13 PIK58203.1 - 0.53 10.8 4.0 0.35 11.4 1.6 1.9 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain DUF4407 PF14362.6 PIK58203.1 - 0.69 9.2 3.5 1.1 8.6 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 PIK58203.1 - 1.1 7.8 3.1 1.5 7.3 3.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HR1 PF02185.16 PIK58203.1 - 5.1 7.3 15.2 8.4 6.6 9.7 2.7 2 0 0 2 2 2 0 Hr1 repeat DNApol3-delta_C PF09115.10 PIK58204.1 - 1.1 9.8 4.3 2.3 8.7 0.6 2.5 2 0 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal Synaptobrevin PF00957.21 PIK58205.1 - 1.4e-15 56.8 0.2 2.5e-15 56.1 0.2 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 PIK58205.1 - 5.3e-11 42.4 0.0 1.4e-10 41.1 0.0 1.7 2 0 0 2 2 2 1 Regulated-SNARE-like domain MORN PF02493.20 PIK58207.1 - 3.2e-43 143.1 41.4 7.4e-08 31.8 1.0 9.3 9 0 0 9 9 9 9 MORN repeat DUF543 PF04418.12 PIK58209.1 - 1e-07 31.8 0.1 1.2e-07 31.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Myb_DNA-binding PF00249.31 PIK58210.1 - 1.2e-09 38.2 0.2 2.7e-09 37.1 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK58210.1 - 1.1e-05 25.5 0.1 1.1e-05 25.5 0.1 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 PIK58210.1 - 0.0034 17.7 3.1 0.0099 16.2 0.4 2.9 2 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain SLIDE PF09111.10 PIK58210.1 - 0.067 13.2 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 SLIDE SANT_DAMP1_like PF16282.5 PIK58210.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Sulfotransfer_1 PF00685.27 PIK58211.1 - 2.7e-37 128.7 0.3 3e-37 128.6 0.3 1.0 1 0 0 1 1 1 1 Sulfotransferase domain SpoVIF PF14069.6 PIK58211.1 - 0.0046 16.7 0.2 0.0069 16.1 0.2 1.2 1 0 0 1 1 1 1 Stage VI sporulation protein F Glypican PF01153.19 PIK58212.1 - 4.2e-26 91.9 1.7 1.2e-25 90.4 1.7 1.6 1 1 0 1 1 1 1 Glypican Lectin_C PF00059.21 PIK58212.1 - 1.4e-11 45.1 0.0 3.7e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Lectin C-type domain PriX PF18689.1 PIK58212.1 - 0.012 16.0 0.4 0.045 14.1 0.3 2.1 1 1 0 1 1 1 0 Primase X ASH PF15780.5 PIK58213.1 - 9.6e-11 41.8 2.6 0.045 14.0 0.0 7.3 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 PIK58213.1 - 3.8e-07 30.0 0.2 0.15 12.1 0.0 5.7 5 0 0 5 5 5 2 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 PIK58213.1 - 3.1e-06 27.0 0.1 1.6 8.6 0.0 5.0 4 0 0 4 4 4 2 MSP (Major sperm protein) domain PapD-like PF14874.6 PIK58213.1 - 0.00085 19.4 0.2 8.3 6.6 0.0 4.4 5 0 0 5 5 5 2 Flagellar-associated PapD-like Med4 PF10018.9 PIK58214.1 - 0.0017 18.1 1.5 0.0022 17.7 1.5 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 CENP-H PF05837.12 PIK58214.1 - 0.0032 17.9 6.4 0.0049 17.3 6.4 1.3 1 0 0 1 1 1 1 Centromere protein H (CENP-H) Spc7 PF08317.11 PIK58214.1 - 0.0033 16.4 5.3 0.0041 16.1 5.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein FliJ PF02050.16 PIK58214.1 - 0.0039 17.4 1.6 0.0065 16.7 1.6 1.4 1 0 0 1 1 1 1 Flagellar FliJ protein Imm6 PF14434.6 PIK58214.1 - 0.012 15.5 0.8 0.018 14.9 0.8 1.2 1 0 0 1 1 1 0 Immunity protein Imm6 Katanin_con80 PF13925.6 PIK58214.1 - 0.03 14.4 1.6 0.044 13.8 1.0 1.6 1 1 1 2 2 2 0 con80 domain of Katanin FlaC_arch PF05377.11 PIK58214.1 - 0.039 14.3 3.3 0.22 12.0 3.3 2.1 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 PIK58214.1 - 0.041 14.5 1.0 0.1 13.3 1.0 1.7 1 0 0 1 1 1 0 SlyX DUF4404 PF14357.6 PIK58214.1 - 0.056 14.1 1.2 0.098 13.3 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) SpecificRecomb PF10136.9 PIK58214.1 - 0.072 11.4 0.7 0.083 11.2 0.7 1.0 1 0 0 1 1 1 0 Site-specific recombinase Endonuc-EcoRV PF09233.11 PIK58214.1 - 0.074 12.4 0.3 0.11 11.9 0.3 1.2 1 0 0 1 1 1 0 Restriction endonuclease EcoRV Tup_N PF08581.10 PIK58214.1 - 0.08 13.3 5.9 0.35 11.2 1.5 2.3 2 0 0 2 2 2 0 Tup N-terminal ABC_tran_CTD PF16326.5 PIK58214.1 - 0.16 12.3 10.5 1.3 9.3 6.8 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain TMF_DNA_bd PF12329.8 PIK58214.1 - 0.24 11.4 5.8 0.61 10.1 5.5 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Spc24 PF08286.11 PIK58214.1 - 0.25 11.6 2.9 0.48 10.7 2.9 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TMPIT PF07851.13 PIK58214.1 - 0.46 9.7 2.8 0.56 9.4 2.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 PIK58214.1 - 0.8 10.0 6.5 0.73 10.1 4.6 1.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain LPP PF04728.13 PIK58214.1 - 1.4 9.4 5.6 0.66 10.4 1.2 2.4 2 1 1 3 3 2 0 Lipoprotein leucine-zipper Sulfotransfer_1 PF00685.27 PIK58215.1 - 2.3e-07 30.6 0.0 2.5e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK58215.1 - 0.0046 17.4 0.0 0.0052 17.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family G-alpha PF00503.20 PIK58216.1 - 2e-15 56.9 4.9 1.3e-14 54.2 4.9 1.8 1 1 0 1 1 1 1 G-protein alpha subunit RNA_pol_Rpb1_3 PF04983.18 PIK58216.1 - 0.12 12.2 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 G-alpha PF00503.20 PIK58217.1 - 2.1e-39 135.7 0.1 2.5e-39 135.4 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit SH2 PF00017.24 PIK58218.1 - 6.2e-13 48.6 0.0 1.7e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 PIK58218.1 - 4.5e-12 45.5 0.2 5e-11 42.1 0.2 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK58218.1 - 6e-08 32.2 0.1 1.8e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 SH3 domain Death PF00531.22 PIK58218.1 - 1.6e-07 31.4 0.3 1.1e-06 28.7 0.1 2.3 2 0 0 2 2 2 1 Death domain SH2_2 PF14633.6 PIK58218.1 - 0.017 14.5 0.2 0.64 9.4 0.0 2.4 1 1 1 2 2 2 0 SH2 domain SH3_9 PF14604.6 PIK58218.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_12 PF18129.1 PIK58220.1 - 5.7e-19 68.0 0.0 1.3e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 PIK58220.1 - 3.5e-15 56.0 0.0 8.4e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain XRN1_D1 PF18332.1 PIK58220.1 - 1.2e-11 44.8 0.1 4.5e-11 42.9 0.1 1.9 1 1 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN_M PF17846.1 PIK58222.1 - 4.4e-48 164.3 1.6 4.4e-48 164.3 1.6 1.6 1 1 1 2 2 2 1 Xrn1 helical domain Myosin_tail_1 PF01576.19 PIK58222.1 - 0.016 13.0 0.4 0.022 12.6 0.4 1.1 1 0 0 1 1 1 0 Myosin tail XRN_M PF17846.1 PIK58223.1 - 1.3e-16 60.7 0.0 1.6e-16 60.4 0.0 1.0 1 0 0 1 1 1 1 Xrn1 helical domain Sterile PF03015.19 PIK58223.1 - 0.013 15.7 0.7 0.017 15.4 0.0 1.4 2 0 0 2 2 2 0 Male sterility protein XRN_N PF03159.18 PIK58224.1 - 6.6e-91 304.0 0.0 9e-91 303.6 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Ski_Sno PF02437.17 PIK58225.1 - 2e-45 153.0 0.7 2e-45 153.0 0.7 1.9 2 0 0 2 2 2 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 PIK58225.1 - 2.1e-26 92.0 4.5 4.8e-26 90.8 4.5 1.6 1 0 0 1 1 1 1 c-SKI Smad4 binding domain Jas PF16135.5 PIK58225.1 - 3.8 7.8 7.5 0.44 10.8 2.0 2.2 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling YabA PF06156.13 PIK58226.1 - 0.0016 19.0 1.2 0.0016 19.0 1.2 2.1 2 0 0 2 2 2 1 Initiation control protein YabA CSN7a_helixI PF18392.1 PIK58227.1 - 1.9e-19 69.3 6.6 3.5e-19 68.4 6.6 1.5 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain DUF4435 PF14491.6 PIK58227.1 - 0.006 16.5 0.5 0.0084 16.0 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4435) STAT_alpha PF01017.20 PIK58227.1 - 0.013 15.4 0.4 0.025 14.5 0.4 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain HI0933_like PF03486.14 PIK58227.1 - 0.062 12.0 2.0 0.066 11.9 0.5 1.7 2 0 0 2 2 2 0 HI0933-like protein DMPK_coil PF08826.10 PIK58227.1 - 0.08 13.1 0.8 0.2 11.8 0.8 1.6 1 0 0 1 1 1 0 DMPK coiled coil domain like ACCA PF03255.14 PIK58227.1 - 0.098 12.5 1.4 10 6.0 1.2 2.2 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF3336 PF11815.8 PIK58227.1 - 0.66 9.7 4.9 1.2 8.9 4.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3336) zf-RING_UBOX PF13445.6 PIK58228.1 - 1.2e-08 34.8 4.0 1.2e-08 34.8 4.0 3.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-B_box PF00643.24 PIK58228.1 - 2.9e-08 33.7 8.0 2.9e-08 33.7 8.0 4.7 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4_4 PF15227.6 PIK58228.1 - 2.3e-07 30.9 5.2 2.3e-07 30.9 5.2 4.0 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK58228.1 - 1.7e-06 27.8 2.9 1.7e-06 27.8 2.9 4.0 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK58228.1 - 8.2e-06 25.6 3.3 8.2e-06 25.6 3.3 3.7 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK58228.1 - 8.2e-05 22.4 3.4 8.2e-05 22.4 3.4 4.4 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) fn3 PF00041.21 PIK58228.1 - 0.0005 20.4 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_5 PF14634.6 PIK58228.1 - 0.00066 19.6 1.7 0.00066 19.6 1.7 4.6 5 0 0 5 5 3 1 zinc-RING finger domain Flagellar_rod PF05149.12 PIK58228.1 - 0.00093 18.7 1.0 0.0015 18.1 1.0 1.2 1 0 0 1 1 1 1 Paraflagellar rod protein zf-RING_2 PF13639.6 PIK58228.1 - 0.0064 16.8 3.2 0.0064 16.8 3.2 4.4 4 0 0 4 4 3 1 Ring finger domain zf-RING_6 PF14835.6 PIK58228.1 - 0.0098 15.8 1.2 0.0098 15.8 1.2 3.1 4 0 0 4 4 2 1 zf-RING of BARD1-type protein HAUS-augmin3 PF14932.6 PIK58228.1 - 0.01 15.4 3.1 0.018 14.6 3.1 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 IBR PF01485.21 PIK58228.1 - 0.016 15.5 1.7 0.016 15.5 1.7 3.9 4 0 0 4 4 4 0 IBR domain, a half RING-finger domain Prok-RING_4 PF14447.6 PIK58228.1 - 0.017 14.9 3.7 0.017 14.9 3.7 4.3 4 0 0 4 4 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 PIK58228.1 - 0.028 14.5 2.0 0.028 14.5 2.0 3.7 3 0 0 3 3 3 0 zinc RING finger of MSL2 Cast PF10174.9 PIK58228.1 - 0.03 12.6 6.5 0.042 12.1 6.5 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone SPRY PF00622.28 PIK58228.1 - 0.058 13.5 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 SPRY domain DNA_topoisoIV PF00521.20 PIK58228.1 - 0.061 12.2 1.9 0.095 11.6 1.9 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Mce4_CUP1 PF11887.8 PIK58228.1 - 0.13 11.7 0.3 0.24 10.8 0.3 1.4 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative YkyA PF10368.9 PIK58228.1 - 0.25 11.0 5.3 0.4 10.3 5.3 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein KELK PF15796.5 PIK58228.1 - 0.29 11.6 3.5 0.64 10.5 3.5 1.6 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF1664 PF07889.12 PIK58228.1 - 0.69 10.0 3.1 1.4 9.0 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TEX13 PF15186.6 PIK58228.1 - 1 9.0 4.1 2.1 8.0 4.1 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family zf-CRD PF17979.1 PIK58228.1 - 1.2 9.2 27.5 0.042 14.0 7.1 3.3 2 1 1 3 3 3 0 Cysteine rich domain with multizinc binding regions Mito_carr PF00153.27 PIK58229.1 - 1.4e-42 143.5 0.4 6.3e-17 61.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein COesterase PF00135.28 PIK58230.1 - 7.2e-89 299.0 0.0 8.5e-89 298.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK58230.1 - 6.4e-08 32.7 0.3 4.4e-07 30.0 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK58230.1 - 0.022 15.4 0.0 0.027 15.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 PIK58230.1 - 0.15 11.7 0.7 0.79 9.3 0.7 1.9 1 1 0 1 1 1 0 Putative esterase Say1_Mug180 PF10340.9 PIK58230.1 - 0.21 10.4 0.1 15 4.3 0.0 2.1 2 0 0 2 2 2 0 Steryl acetyl hydrolase COesterase PF00135.28 PIK58231.1 - 2e-06 27.0 0.2 2.1e-06 26.9 0.2 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK58231.1 - 3.5e-06 26.6 3.3 3.5e-06 26.6 3.3 1.9 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK58232.1 - 1.2e-54 186.0 0.0 1.6e-54 185.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 PIK58232.1 - 0.0022 17.7 3.6 0.0022 17.7 3.6 1.9 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain DUF773 PF05600.12 PIK58233.1 - 4.5e-155 517.3 22.4 3e-103 346.3 11.6 2.0 1 1 1 2 2 2 2 CDK5 regulatory subunit-associated protein 3 GYF PF02213.16 PIK58233.1 - 0.13 12.0 0.1 0.32 10.7 0.1 1.6 1 0 0 1 1 1 0 GYF domain VGLL4 PF15245.6 PIK58233.1 - 0.15 12.1 1.8 0.25 11.4 1.8 1.3 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 60KD_IMP PF02096.20 PIK58233.1 - 1.1 9.1 8.1 0.68 9.8 4.8 2.3 2 0 0 2 2 2 0 60Kd inner membrane protein CREPT PF16566.5 PIK58233.1 - 7.4 6.7 13.5 11 6.1 8.1 3.1 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour STAT_int PF02865.17 PIK58233.1 - 8.5 6.9 11.7 6 7.4 0.5 3.1 3 0 0 3 3 3 0 STAT protein, protein interaction domain zf-C2H2_4 PF13894.6 PIK58234.1 - 0.022 15.5 0.2 0.022 15.5 0.2 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK58234.1 - 0.09 12.8 0.1 0.09 12.8 0.1 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK58234.1 - 0.77 10.3 4.7 0.41 11.2 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type ATP-synt_C PF00137.21 PIK58235.1 - 6.9e-05 23.1 3.7 0.00014 22.1 3.7 1.5 1 0 0 1 1 1 1 ATP synthase subunit C DUF3211 PF11485.8 PIK58236.1 - 0.0059 16.8 0.2 0.0098 16.1 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3211) DUF3153 PF11353.8 PIK58236.1 - 0.86 9.1 3.3 3.4 7.2 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3153) LSDAT_euk PF18139.1 PIK58237.1 - 6.6e-74 248.7 3.6 2.5e-39 135.3 0.9 2.3 2 0 0 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 PIK58237.1 - 1.6e-23 83.0 2.2 2.3e-14 53.1 0.1 2.4 2 0 0 2 2 2 2 SLOG in TRPM, prokaryote Ion_trans PF00520.31 PIK58237.1 - 8.6e-15 54.6 18.3 1.4e-14 54.0 18.3 1.3 1 0 0 1 1 1 1 Ion transport protein NUDIX PF00293.28 PIK58237.1 - 4.2e-06 26.8 0.2 1.4e-05 25.1 0.2 1.8 1 0 0 1 1 1 1 NUDIX domain PKD_channel PF08016.12 PIK58237.1 - 0.00097 17.9 13.9 0.0081 14.9 8.5 2.5 1 1 1 2 2 2 2 Polycystin cation channel Chordopox_L2 PF05803.12 PIK58237.1 - 0.27 11.1 2.6 2.8 7.9 0.4 2.8 2 0 0 2 2 2 0 Chordopoxvirus L2 protein OPT PF03169.15 PIK58238.1 - 0.19 10.3 0.0 0.26 9.9 0.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein Kelch_1 PF01344.25 PIK58239.1 - 1.7e-83 274.0 16.9 6.9e-15 54.4 0.9 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK58239.1 - 5.7e-54 178.8 8.1 1.9e-09 37.5 0.1 7.1 2 1 5 7 7 7 6 Kelch motif Kelch_2 PF07646.15 PIK58239.1 - 9.6e-42 139.4 7.6 4.4e-07 29.6 0.1 6.4 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 PIK58239.1 - 1.7e-32 111.9 0.2 3.1e-32 111.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 PIK58239.1 - 1.2e-30 105.2 5.5 2.2e-05 24.4 0.0 6.2 5 1 1 6 6 6 6 Galactose oxidase, central domain BACK PF07707.15 PIK58239.1 - 4.2e-29 100.7 0.0 9.6e-29 99.5 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 PIK58239.1 - 4.3e-20 71.5 13.7 2.4e-05 24.5 0.0 6.1 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK58239.1 - 1.8e-11 43.8 6.4 0.36 10.9 0.1 6.2 6 0 0 6 6 6 3 Kelch motif DUF3342 PF11822.8 PIK58239.1 - 0.001 19.2 0.4 0.032 14.4 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Glyoxal_oxid_N PF07250.11 PIK58239.1 - 0.05 12.8 0.4 1.1 8.3 0.0 2.7 2 1 1 3 3 3 0 Glyoxal oxidase N-terminus zf-RanBP PF00641.18 PIK58240.1 - 0.00036 19.8 7.8 0.00036 19.8 7.8 2.1 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-MYND PF01753.18 PIK58240.1 - 8.5 6.6 7.2 0.8 9.8 0.5 2.6 2 0 0 2 2 2 0 MYND finger SNF2_N PF00176.23 PIK58241.1 - 1e-25 90.2 0.0 1.6e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 PIK58241.1 - 1.7e-10 41.2 0.0 3.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK58241.1 - 2.7e-09 37.3 0.1 7.8e-06 26.0 0.0 3.0 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 PIK58241.1 - 0.006 15.8 0.0 0.0096 15.2 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 PIK58241.1 - 0.016 15.5 0.1 0.1 12.8 0.0 2.4 2 1 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.14 PIK58241.1 - 0.047 13.7 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_11 PF13086.6 PIK58241.1 - 0.17 11.6 0.0 0.63 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Pyridoxal_deC PF00282.19 PIK58242.1 - 1e-88 297.6 0.0 1.3e-88 297.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 PIK58242.1 - 1.9e-14 53.6 0.0 2.7e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 PIK58242.1 - 6.1e-07 28.7 0.0 8.8e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V SepSecS PF05889.13 PIK58242.1 - 2.5e-05 23.1 0.0 4.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_1_2 PF00155.21 PIK58242.1 - 0.0086 15.3 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II UvdE PF03851.14 PIK58242.1 - 0.034 13.4 0.1 0.051 12.8 0.1 1.3 1 0 0 1 1 1 0 UV-endonuclease UvdE T4_Rnl2_C PF18043.1 PIK58242.1 - 0.051 13.7 0.5 0.085 13.0 0.5 1.3 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal RVT_1 PF00078.27 PIK58243.1 - 7.9e-42 143.3 1.4 9.8e-42 143.0 1.4 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L9_C PF03948.14 PIK58243.1 - 0.037 14.5 0.1 0.099 13.1 0.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L9, C-terminal domain DnaJ_C PF01556.18 PIK58243.1 - 0.091 12.8 0.6 5.9 7.0 0.8 2.6 2 1 0 2 2 2 0 DnaJ C terminal domain DUF2555 PF10742.9 PIK58243.1 - 0.15 11.9 0.6 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) C2 PF00168.30 PIK58244.1 - 5.8e-38 129.3 0.0 2.4e-21 75.9 0.0 2.3 2 0 0 2 2 2 2 C2 domain SMP_LBD PF17047.5 PIK58244.1 - 3.7e-29 101.5 0.2 6.6e-29 100.6 0.2 1.4 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain KH_6 PF15985.5 PIK58245.1 - 8.6e-14 51.6 0.3 2e-13 50.4 0.3 1.7 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 PIK58245.1 - 3.5e-06 26.8 0.0 6.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Radial_spoke PF04712.12 PIK58246.1 - 2e-05 23.7 0.0 7.1e-05 21.9 0.0 1.7 1 1 1 2 2 2 1 Radial spokehead-like protein Ribosomal_S18 PF01084.20 PIK58247.1 - 1.7e-18 66.5 0.1 2.4e-18 66.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S18 Prok-RING_4 PF14447.6 PIK58247.1 - 0.089 12.7 1.8 0.37 10.7 0.0 2.2 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Josephin PF02099.17 PIK58248.1 - 6e-57 192.3 1.4 3.7e-54 183.2 0.0 2.7 2 1 1 3 3 3 2 Josephin SUIM_assoc PF16619.5 PIK58248.1 - 0.00027 21.0 0.4 0.00027 21.0 0.4 2.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.20 PIK58248.1 - 0.027 14.4 17.4 0.52 10.4 2.8 3.7 3 0 0 3 3 3 0 Ubiquitin interaction motif MHB PF16525.5 PIK58248.1 - 0.033 14.4 0.9 0.27 11.5 0.1 2.5 1 1 1 2 2 2 0 Haemophore, haem-binding RNA_pol_A_bac PF01000.26 PIK58250.1 - 3.6e-29 101.4 0.0 5.2e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 PIK58250.1 - 3e-09 36.2 0.0 3.8e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 PIK58251.1 - 3.1e-11 42.5 0.0 3.5e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ig_3 PF13927.6 PIK58252.1 - 6.7e-55 183.6 7.1 1.6e-11 44.6 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 PIK58252.1 - 1.5e-48 162.8 0.3 5.2e-11 42.5 0.0 5.5 5 1 0 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK58252.1 - 4.6e-38 129.4 5.0 1.8e-09 37.8 0.0 5.1 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 PIK58252.1 - 5.2e-27 93.9 4.9 0.00052 20.1 0.0 5.6 5 1 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 PIK58252.1 - 1.1e-16 60.9 6.4 0.011 15.9 0.0 7.8 5 3 2 7 7 7 3 Immunoglobulin V-set domain Ig_5 PF16681.5 PIK58252.1 - 1.2e-10 41.6 0.2 0.0084 16.5 0.0 4.6 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK58252.1 - 1.9e-07 30.5 0.0 0.11 12.1 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain Ig_4 PF16680.5 PIK58252.1 - 1.6e-06 28.2 0.5 0.0028 17.9 0.0 4.0 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK58252.1 - 3.6e-05 23.7 6.7 0.98 9.5 0.4 5.3 5 2 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK58252.1 - 4.1e-05 23.6 0.6 3.2 7.9 0.0 4.7 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 PIK58252.1 - 0.00039 20.4 1.8 1.2 9.1 0.0 4.1 4 1 0 4 4 4 2 CD47 immunoglobulin-like domain Fer2_4 PF13510.6 PIK58252.1 - 0.015 15.4 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain DLIC PF05783.11 PIK58253.1 - 1.4e-08 34.0 0.1 3e-07 29.6 0.1 2.1 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 PIK58253.1 - 1.8e-07 31.4 0.0 8.6e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 PIK58253.1 - 6.5e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 PIK58253.1 - 8.5e-05 22.1 1.2 0.00017 21.1 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK58253.1 - 0.0003 20.4 0.0 0.037 13.6 0.0 2.3 1 1 1 2 2 2 1 Ras family Arf PF00025.21 PIK58253.1 - 0.0012 18.4 0.0 0.0085 15.6 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family GatB_Yqey PF02637.18 PIK58253.1 - 0.018 14.9 0.9 4.3 7.2 0.2 2.3 2 0 0 2 2 2 0 GatB domain MMR_HSR1 PF01926.23 PIK58253.1 - 0.15 12.2 0.3 0.42 10.7 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 PIK58253.1 - 0.15 11.9 1.2 0.23 11.4 0.0 1.9 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Xpo1 PF08389.12 PIK58255.1 - 7.8e-28 97.4 15.5 8.3e-28 97.3 6.0 3.5 4 0 0 4 4 4 2 Exportin 1-like protein IBN_N PF03810.19 PIK58255.1 - 0.001 19.0 0.0 0.0043 16.9 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Lung_7-TM_R PF06814.13 PIK58256.1 - 6.9e-68 229.0 22.4 8e-45 153.3 6.2 2.1 1 1 1 2 2 2 2 Lung seven transmembrane receptor PTPRCAP PF15713.5 PIK58256.1 - 0.11 12.8 6.6 0.09 13.1 1.9 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TRAP_alpha PF03896.16 PIK58256.1 - 2.5 7.2 7.9 0.45 9.7 2.8 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DSPc PF00782.20 PIK58257.1 - 3.5e-28 98.0 0.0 5e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain NHL PF01436.21 PIK58258.1 - 1.4e-10 40.6 1.2 1e-05 25.3 0.0 4.4 4 0 0 4 4 4 2 NHL repeat SGL PF08450.12 PIK58258.1 - 0.00045 19.9 0.1 0.14 11.7 0.0 2.1 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 PIK58258.1 - 0.00076 19.4 0.0 1.5 8.9 0.0 2.8 2 0 0 2 2 2 2 Beta-propeller repeat SdiA-regulated PF06977.11 PIK58258.1 - 0.0025 17.1 0.0 0.15 11.2 0.0 2.3 2 0 0 2 2 2 1 SdiA-regulated DUF5128 PF17170.4 PIK58258.1 - 0.0028 16.9 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 6-bladed beta-propeller ANAPC4_WD40 PF12894.7 PIK58258.1 - 0.021 15.1 0.2 0.051 13.9 0.2 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Ldl_recept_b PF00058.17 PIK58258.1 - 0.18 12.3 0.3 1.9 9.0 0.1 2.8 3 1 0 3 3 3 0 Low-density lipoprotein receptor repeat class B NHL PF01436.21 PIK58259.1 - 5.5e-14 51.4 1.1 2.2e-05 24.2 0.0 6.4 6 0 0 6 6 6 3 NHL repeat SGL PF08450.12 PIK58259.1 - 0.00064 19.4 0.0 0.4 10.2 0.0 2.5 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 PIK58259.1 - 0.0023 17.1 1.1 0.053 12.7 0.1 2.5 3 0 0 3 3 3 1 6-bladed beta-propeller Filamin PF00630.19 PIK58259.1 - 0.014 16.2 0.0 0.042 14.7 0.0 1.9 1 0 0 1 1 1 0 Filamin/ABP280 repeat SdiA-regulated PF06977.11 PIK58259.1 - 0.024 13.8 0.0 0.27 10.4 0.0 2.4 1 1 1 3 3 3 0 SdiA-regulated SBBP PF06739.11 PIK58259.1 - 0.028 14.4 0.2 2.5 8.2 0.0 2.7 2 0 0 2 2 2 0 Beta-propeller repeat Arylesterase PF01731.20 PIK58259.1 - 0.12 12.6 0.9 2 8.7 0.1 2.9 2 1 1 3 3 3 0 Arylesterase zf-C3HC4_2 PF13923.6 PIK58261.1 - 3.6e-10 39.5 9.9 7.9e-10 38.4 9.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK58261.1 - 1.2e-09 38.0 5.5 2.5e-09 37.0 5.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK58261.1 - 1.9e-09 37.2 8.8 3.9e-09 36.2 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK58261.1 - 3.4e-09 36.9 8.2 3.4e-09 36.9 8.2 1.9 2 0 0 2 2 1 1 Ring finger domain NHL PF01436.21 PIK58261.1 - 5e-09 35.8 3.6 1.3e-05 25.0 0.0 5.1 5 0 0 5 5 5 1 NHL repeat zf-C3HC4_3 PF13920.6 PIK58261.1 - 5.8e-09 35.7 7.3 1.1e-08 34.8 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK58261.1 - 4.8e-08 33.0 8.6 1.1e-07 31.9 8.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK58261.1 - 3e-06 27.0 7.7 1.1e-05 25.2 7.8 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 SBBP PF06739.11 PIK58261.1 - 1.2e-05 25.2 0.1 0.043 13.8 0.0 2.8 2 0 0 2 2 2 2 Beta-propeller repeat zf-RING_5 PF14634.6 PIK58261.1 - 1.7e-05 24.7 8.1 2.6e-05 24.1 6.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain SGL PF08450.12 PIK58261.1 - 3.7e-05 23.4 0.4 0.029 14.0 0.0 2.6 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Filamin PF00630.19 PIK58261.1 - 0.0004 21.2 0.0 0.001 19.9 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF5128 PF17170.4 PIK58261.1 - 0.0054 15.9 0.2 0.45 9.6 0.0 2.4 2 0 0 2 2 2 1 6-bladed beta-propeller zf-RING_10 PF16685.5 PIK58261.1 - 0.011 15.8 7.6 0.022 14.9 7.6 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 SdiA-regulated PF06977.11 PIK58261.1 - 0.018 14.3 0.0 0.58 9.3 0.0 2.3 1 1 1 2 2 2 0 SdiA-regulated Zn_ribbon_17 PF17120.5 PIK58261.1 - 0.041 13.5 3.7 0.12 12.0 3.7 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type HypA PF01155.19 PIK58261.1 - 0.051 13.6 2.1 0.12 12.4 2.1 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ANAPC4_WD40 PF12894.7 PIK58261.1 - 0.064 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_4 PF14570.6 PIK58261.1 - 0.11 12.2 6.7 0.34 10.7 6.7 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 PIK58261.1 - 0.27 11.4 7.2 1.9 8.7 4.6 2.8 2 2 0 2 2 2 0 Zinc-binding RING-finger zf-rbx1 PF12678.7 PIK58261.1 - 0.29 11.4 9.1 1.3 9.4 9.1 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 PIK58261.1 - 2.5 8.1 6.8 5.6 7.0 6.8 1.6 1 0 0 1 1 1 0 zinc-ribbons RINGv PF12906.7 PIK58261.1 - 4.5 7.5 8.1 15 5.8 8.1 2.0 1 0 0 1 1 1 0 RING-variant domain PhyH PF05721.13 PIK58264.1 - 8.9e-46 156.8 0.0 1.1e-45 156.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 PIK58264.1 - 0.025 13.3 0.0 8.7 5.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1479) EntA_Immun PF08951.10 PIK58264.1 - 0.53 10.7 2.6 6.8 7.1 0.2 2.6 2 0 0 2 2 2 0 Enterocin A Immunity GDWWSH PF15667.5 PIK58265.1 - 4.1e-34 118.1 3.4 4.9e-34 117.9 3.4 1.1 1 0 0 1 1 1 1 Protein of unknown function with motif GDWWSH Sushi PF00084.20 PIK58266.1 - 1.2e-24 86.6 9.5 6.8e-09 36.2 0.1 3.2 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Trypsin PF00089.26 PIK58267.1 - 2.2e-13 50.5 0.0 2.6e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin Sushi PF00084.20 PIK58268.1 - 1e-24 86.9 10.3 7.8e-09 36.0 0.2 3.2 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) cEGF PF12662.7 PIK58268.1 - 8.4 6.4 14.1 2.6 8.1 0.2 4.4 5 0 0 5 5 5 0 Complement Clr-like EGF-like VWA PF00092.28 PIK58269.1 - 5e-30 105.0 0.0 6.4e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK58269.1 - 4.7e-09 36.9 0.0 1.3e-08 35.4 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 PIK58269.1 - 0.0022 17.9 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Kelch_1 PF01344.25 PIK58270.1 - 3.2e-90 295.5 22.2 4.2e-19 67.9 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK58270.1 - 4.3e-50 166.5 6.0 6.2e-11 42.2 0.0 6.6 3 1 3 6 6 6 6 Kelch motif BACK PF07707.15 PIK58270.1 - 1.6e-34 118.1 0.7 3.4e-34 117.0 0.1 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 PIK58270.1 - 5.1e-33 112.8 1.8 4.4e-07 29.8 0.0 6.3 4 2 2 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 PIK58270.1 - 6.4e-31 106.9 0.7 9.8e-31 106.3 0.2 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 PIK58270.1 - 1.1e-28 98.0 7.1 1.8e-06 27.7 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 PIK58270.1 - 2.8e-28 97.6 11.6 6.1e-05 23.2 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK58270.1 - 9.9e-10 38.2 2.6 0.0056 16.6 0.0 5.5 5 0 0 5 5 5 2 Kelch motif DUF2963 PF11178.8 PIK58270.1 - 0.07 12.8 0.0 16 5.3 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2963) Transcrip_act PF04949.13 PIK58271.1 - 9.4e-08 32.1 24.2 2.1e-07 30.9 24.2 1.6 1 0 0 1 1 1 1 Transcriptional activator RT_RNaseH PF17917.1 PIK58271.1 - 0.017 15.4 1.3 0.049 13.9 1.3 1.8 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58271.1 - 0.024 14.7 0.6 0.089 12.8 0.2 2.1 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase LPP PF04728.13 PIK58271.1 - 0.15 12.4 5.7 1.5 9.2 0.2 2.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper RT_RNaseH PF17917.1 PIK58272.1 - 4.2e-32 110.6 0.2 3.5e-31 107.6 0.1 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58272.1 - 5.8e-24 84.0 0.2 1.9e-23 82.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK58272.1 - 8.9e-23 80.7 0.0 2e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK58272.1 - 4e-15 55.7 3.1 2.6e-14 53.1 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK58272.1 - 3.3e-05 23.6 0.1 8.2e-05 22.3 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK58272.1 - 0.046 14.0 0.1 0.094 12.9 0.1 1.4 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK58273.1 - 2e-27 96.2 0.0 3.1e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) KH_1 PF00013.29 PIK58276.1 - 1e-64 214.2 16.2 2.8e-16 59.1 0.1 4.4 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 PIK58276.1 - 6.1e-17 61.2 11.2 0.003 17.3 0.0 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 PIK58276.1 - 4.3e-13 48.9 10.7 0.0036 17.1 1.1 4.4 4 0 0 4 4 4 4 KH domain KH_5 PF13184.6 PIK58276.1 - 9.2e-08 32.1 7.6 0.97 9.6 0.0 4.9 4 1 0 4 4 4 4 NusA-like KH domain dUTPase PF00692.19 PIK58276.1 - 0.048 13.3 0.0 10 5.8 0.0 2.7 3 0 0 3 3 3 0 dUTPase SBF PF01758.16 PIK58277.1 - 1.3e-26 93.5 13.2 1.3e-26 93.5 13.2 2.4 2 1 1 3 3 3 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK58277.1 - 2.1 6.7 10.8 0.58 8.5 2.0 3.1 2 1 0 2 2 2 0 Membrane transport protein BAG6 PF12057.8 PIK58278.1 - 1.4e-16 60.2 0.1 5.2e-16 58.4 0.1 2.0 1 0 0 1 1 1 1 BCL2-associated athanogene 6 ubiquitin PF00240.23 PIK58278.1 - 7e-12 44.9 0.0 1.5e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 PIK58278.1 - 0.0045 17.4 0.0 0.013 16.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 PIK58278.1 - 0.032 14.1 0.0 0.073 12.9 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 PIK58278.1 - 0.046 14.3 0.0 0.32 11.6 0.0 2.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK58278.1 - 0.075 13.2 0.0 0.35 11.0 0.0 2.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ALMT PF11744.8 PIK58278.1 - 8.8 5.0 6.0 17 4.1 6.0 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S28 PF05577.12 PIK58279.1 - 1.3e-88 297.7 0.0 1.6e-88 297.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 PIK58279.1 - 1.9e-06 27.7 0.0 3.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S37 PF05576.11 PIK58279.1 - 0.00098 17.9 0.0 0.0019 17.0 0.0 1.4 1 0 0 1 1 1 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 PIK58279.1 - 0.0022 17.3 0.0 0.0046 16.2 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 PIK58279.1 - 0.017 14.6 0.7 0.027 13.9 0.1 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family AAA_11 PF13086.6 PIK58280.1 - 2.3e-28 99.7 1.6 2.5e-28 99.6 0.7 1.5 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 PIK58280.1 - 4.9e-15 55.7 0.8 1.1e-14 54.5 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK58280.1 - 1.9e-06 27.7 0.0 4.9e-06 26.4 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 PIK58280.1 - 0.083 13.2 0.0 0.15 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 PIK58280.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3786 PF12654.7 PIK58280.1 - 0.11 12.1 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3786) RNB PF00773.19 PIK58281.1 - 1.4e-66 225.1 0.0 1.9e-65 221.3 0.0 2.4 1 1 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 PIK58281.1 - 0.0031 17.5 0.0 0.01 15.8 0.0 2.0 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 PIK58281.1 - 0.0099 16.0 0.1 1.3 9.3 0.0 3.3 3 0 0 3 3 3 1 Cold shock domain DUF3047 PF11249.8 PIK58281.1 - 0.024 14.1 0.1 0.94 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3047) Peptidase_S28 PF05577.12 PIK58283.1 - 3.6e-15 55.7 0.0 4.3e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 AAA_12 PF13087.6 PIK58284.1 - 3.5e-75 252.0 0.7 7.1e-41 140.0 0.2 2.9 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 PIK58284.1 - 7.6e-72 242.2 11.9 3.3e-48 164.8 0.0 5.2 5 1 1 6 6 5 3 AAA domain RNB PF00773.19 PIK58284.1 - 2.1e-71 240.9 0.0 8.3e-71 239.0 0.0 2.1 1 1 0 1 1 1 1 RNB domain AAA_30 PF13604.6 PIK58284.1 - 3.5e-18 66.0 0.0 8.7e-05 22.3 0.0 3.9 3 1 0 3 3 3 3 AAA domain AAA_19 PF13245.6 PIK58284.1 - 7.3e-14 52.3 0.1 6.4e-06 26.6 0.0 3.3 2 1 0 2 2 2 2 AAA domain UvrD_C PF13361.6 PIK58284.1 - 9.9e-07 28.4 0.5 0.02 14.3 0.2 3.3 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 PIK58284.1 - 2.1e-06 28.1 0.1 1.3 9.3 0.0 4.3 3 0 0 3 3 3 2 AAA domain ResIII PF04851.15 PIK58284.1 - 4.2e-06 26.9 0.2 0.0018 18.3 0.0 3.5 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 PIK58284.1 - 4.6e-06 26.4 6.2 0.00035 20.2 0.0 4.9 4 1 1 5 5 5 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 PIK58284.1 - 8.9e-06 25.4 5.0 0.0084 15.9 0.3 4.1 3 1 0 3 3 3 2 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 PIK58284.1 - 5.6e-05 23.0 7.5 0.87 9.3 0.0 5.3 5 1 0 5 5 4 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 PIK58284.1 - 9.5e-05 22.2 0.2 1.4 8.7 0.0 3.8 3 2 0 3 3 3 2 DEAD/DEAH box helicase OB_Dis3 PF17849.1 PIK58284.1 - 0.001 19.0 1.1 0.0066 16.5 0.2 2.9 2 1 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) LSDAT_euk PF18139.1 PIK58284.1 - 0.0068 15.8 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM AAA_5 PF07728.14 PIK58284.1 - 0.0077 16.2 0.0 3.9 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) CSD2 PF17876.1 PIK58284.1 - 0.034 14.3 0.0 2.9 8.1 0.0 2.9 2 0 0 2 2 2 0 Cold shock domain Mg_chelatase PF01078.21 PIK58284.1 - 0.036 13.5 0.0 9.5 5.5 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 PIK58284.1 - 0.046 13.2 0.0 2.1 7.7 0.0 3.1 3 0 0 3 3 3 0 PhoH-like protein Terminase_6 PF03237.15 PIK58284.1 - 0.08 12.6 0.1 0.35 10.5 0.0 2.2 2 0 0 2 2 2 0 Terminase-like family Helicase_RecD PF05127.14 PIK58284.1 - 0.083 12.7 0.1 1.1 9.1 0.0 3.1 3 0 0 3 3 3 0 Helicase AAA PF00004.29 PIK58284.1 - 0.12 12.8 0.0 24 5.3 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK58284.1 - 0.17 12.3 0.0 36 4.7 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain zf-C2H2_2 PF12756.7 PIK58284.1 - 8.4 6.8 9.1 1 9.7 0.4 3.4 3 0 0 3 3 2 0 C2H2 type zinc-finger (2 copies) KDZ PF18758.1 PIK58286.1 - 7.8e-46 156.5 0.2 1.2e-45 155.9 0.2 1.2 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK58286.1 - 1.7e-14 53.8 0.1 5.1e-14 52.3 0.1 1.8 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC1 PF18802.1 PIK58286.1 - 4e-12 46.2 0.3 1.3e-11 44.5 0.3 1.9 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK58286.1 - 7.1e-05 22.6 1.7 0.00015 21.6 0.1 2.4 3 0 0 3 3 3 1 CxC3 like cysteine cluster associated with KDZ transposases SNF2_N PF00176.23 PIK58286.1 - 0.014 14.1 0.0 0.032 13.0 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain PDZ PF00595.24 PIK58287.1 - 7.9e-05 22.9 0.0 0.00016 22.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK58287.1 - 0.0046 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RVT_1 PF00078.27 PIK58288.1 - 1.6e-29 103.1 0.1 2.1e-29 102.7 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK58288.1 - 1.1e-05 24.9 0.0 0.00019 21.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) MAPEG PF01124.18 PIK58289.1 - 3.5e-21 75.4 0.0 4.1e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 MAPEG family IRS PF02174.17 PIK58290.1 - 9.4e-15 54.3 0.0 1.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) INTS5_C PF14838.6 PIK58291.1 - 0.014 14.1 0.0 0.017 13.8 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 5 C-terminus INTS5_C PF14838.6 PIK58292.1 - 5.3e-114 382.4 9.7 7e-114 382.0 9.7 1.1 1 0 0 1 1 1 1 Integrator complex subunit 5 C-terminus INTS5_N PF14837.6 PIK58292.1 - 4.6e-73 245.3 0.1 1e-72 244.2 0.1 1.6 1 0 0 1 1 1 1 Integrator complex subunit 5 N-terminus Nop14 PF04147.12 PIK58292.1 - 9.9 4.2 14.5 16 3.6 14.5 1.3 1 0 0 1 1 1 0 Nop14-like family PDZ PF00595.24 PIK58293.1 - 8.5e-07 29.2 0.0 1.7e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK58293.1 - 0.00016 21.4 0.0 0.00058 19.6 0.0 2.0 1 0 0 1 1 1 1 PDZ domain RT_RNaseH PF17917.1 PIK58294.1 - 1.2e-31 109.0 0.2 7.2e-31 106.6 0.1 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58294.1 - 1.3e-23 82.9 0.2 3.5e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK58294.1 - 1e-22 80.5 0.0 4.2e-22 78.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK58294.1 - 1.1e-14 54.2 3.1 4.7e-14 52.2 1.5 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK58294.1 - 4.1e-05 23.3 0.1 0.00015 21.5 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK58295.1 - 5.8e-27 94.6 0.0 8.7e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TCR PF03638.15 PIK58297.1 - 0.99 9.8 19.9 2.9 8.3 19.9 1.7 1 1 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain rve PF00665.26 PIK58298.1 - 0.00042 20.5 0.0 0.00085 19.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 PIK58299.1 - 7.5e-05 22.6 15.2 0.0038 17.2 3.3 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK58299.1 - 7.7e-05 22.4 6.2 0.0035 17.1 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK58299.1 - 0.00017 21.2 14.3 0.34 10.7 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK58299.1 - 2.5 8.4 11.9 0.51 10.6 6.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain BEN PF10523.9 PIK58300.1 - 3.7e-07 30.3 0.1 1e-06 28.9 0.1 1.8 1 1 0 1 1 1 1 BEN domain DUF4763 PF15960.5 PIK58300.1 - 0.0047 16.3 1.5 0.0071 15.7 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) DUF4093 PF13331.6 PIK58300.1 - 0.042 14.3 0.2 0.086 13.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Polo_box_3 PF18544.1 PIK58300.1 - 0.16 12.6 1.0 0.46 11.1 0.2 1.9 1 1 1 2 2 2 0 Polo box domain Spc24 PF08286.11 PIK58300.1 - 0.26 11.5 3.7 0.63 10.3 3.7 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 MMU163 PF17119.5 PIK58302.1 - 0.022 13.9 0.0 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis GIY-YIG PF01541.24 PIK58303.1 - 1.5e-05 25.2 0.3 2.8e-05 24.3 0.3 1.6 1 1 0 1 1 1 1 GIY-YIG catalytic domain Elf1 PF05129.13 PIK58303.1 - 6.1 7.0 6.8 74 3.5 6.8 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Stork_head PF10264.9 PIK58304.1 - 0.03 14.5 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain FAM193_C PF15914.5 PIK58304.1 - 0.033 13.9 0.2 0.091 12.5 0.2 1.8 1 0 0 1 1 1 0 FAM193 family C-terminal Glyco_transf_4 PF13439.6 PIK58304.1 - 0.11 12.5 0.1 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 Glycosyltransferase Family 4 RVT_1 PF00078.27 PIK58305.1 - 5e-30 104.7 0.1 5.7e-30 104.5 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GAS PF13851.6 PIK58306.1 - 4.4e-11 42.5 120.5 0.00018 20.9 28.1 4.6 1 1 4 5 5 5 5 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK58306.1 - 8e-11 42.2 138.2 8.7e-05 22.5 41.2 3.8 1 1 3 4 4 4 4 Ezrin/radixin/moesin family KASH_CCD PF14662.6 PIK58306.1 - 3.3e-08 33.6 123.0 0.033 14.0 26.4 6.0 1 1 5 6 6 6 5 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 PIK58306.1 - 1.8e-07 31.7 142.1 0.019 15.5 32.7 5.9 1 1 4 5 5 5 3 Apg6 coiled-coil region Fez1 PF06818.15 PIK58306.1 - 0.00018 22.0 114.4 0.051 14.0 34.8 4.1 1 1 3 4 4 4 4 Fez1 DUF4472 PF14739.6 PIK58306.1 - 0.0011 19.7 104.2 0.57 10.9 18.1 7.3 1 1 6 8 8 8 5 Domain of unknown function (DUF4472) HIP1_clath_bdg PF16515.5 PIK58306.1 - 0.0073 16.9 127.0 1.3 9.6 16.2 7.4 1 1 8 9 9 9 4 Clathrin-binding domain of Huntingtin-interacting protein 1 HBM PF16591.5 PIK58306.1 - 0.008 15.6 77.2 0.17 11.3 12.1 5.3 1 1 3 4 4 4 4 Helical bimodular sensor domain Frankia_peptide PF14407.6 PIK58306.1 - 0.046 13.7 26.4 0.69 9.9 0.5 7.9 1 1 5 7 7 7 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Lebercilin PF15619.6 PIK58306.1 - 0.08 12.6 120.8 0.56 9.8 15.6 6.8 1 1 4 6 6 6 0 Ciliary protein causing Leber congenital amaurosis disease DUF1495 PF07381.11 PIK58306.1 - 0.38 10.6 2.9 35 4.3 0.0 4.4 2 2 1 5 5 5 0 Winged helix DNA-binding domain (DUF1495) GD_N PF16030.5 PIK58306.1 - 0.79 10.0 32.9 2.6 8.4 1.3 6.1 1 1 6 8 8 8 0 Serine protease gd N-terminus ATG16 PF08614.11 PIK58306.1 - 1.2 9.3 128.3 0.029 14.6 30.2 4.9 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) Cep57_MT_bd PF06657.13 PIK58306.1 - 1.3 9.5 85.9 1 9.9 8.8 8.7 1 1 9 10 10 10 0 Centrosome microtubule-binding domain of Cep57 Spc7 PF08317.11 PIK58306.1 - 1.9 7.3 115.0 0.23 10.3 23.4 4.3 1 1 5 6 6 6 0 Spc7 kinetochore protein DUF150_C PF17384.2 PIK58306.1 - 2.1 8.6 49.3 11 6.3 0.3 10.0 2 1 8 10 10 10 0 RimP C-terminal SH3 domain TACC_C PF05010.14 PIK58306.1 - 7.1 6.4 98.3 8.2 6.2 31.5 3.7 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ZU5 PF00791.20 PIK58307.1 - 2e-09 37.7 0.4 6.8e-09 36.0 0.1 2.0 2 0 0 2 2 2 1 ZU5 domain RT_RNaseH_2 PF17919.1 PIK58309.1 - 6.4e-33 112.8 0.1 1.7e-32 111.4 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58309.1 - 3.5e-28 97.9 0.0 1e-27 96.4 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58309.1 - 5.3e-19 68.6 0.0 9.8e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK58309.1 - 0.00097 19.1 2.8 0.00097 19.1 2.8 2.6 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK58309.1 - 0.0072 16.9 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK58309.1 - 0.018 15.7 0.0 0.039 14.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zinc-ribbons_6 PF07191.12 PIK58309.1 - 0.47 10.5 5.8 2.2 8.3 5.2 2.4 2 0 0 2 2 2 0 zinc-ribbons PQQ_3 PF13570.6 PIK58310.1 - 0.0031 17.9 0.1 1.5 9.4 0.1 3.1 3 1 1 4 4 4 2 PQQ-like domain Beta_propel PF09826.9 PIK58310.1 - 0.03 13.2 0.0 0.042 12.7 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain DUF5018 PF16410.5 PIK58310.1 - 0.074 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) AA_permease PF00324.21 PIK58313.1 - 5.1e-65 219.9 50.3 7.7e-57 192.9 34.7 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 PIK58313.1 - 8.2e-10 38.1 54.6 1.2e-08 34.3 54.6 2.2 1 1 0 1 1 1 1 Amino acid permease Anoct_dimer PF16178.5 PIK58314.1 - 3.7e-27 95.5 0.1 5.1e-27 95.1 0.1 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Anoctamin PF04547.12 PIK58314.1 - 2.7e-25 89.1 0.6 3.2e-25 88.9 0.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoctamin PF04547.12 PIK58315.1 - 4e-102 342.4 0.2 4.9e-102 342.1 0.2 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel PQ-loop PF04193.14 PIK58316.1 - 3.1e-19 68.5 6.5 1.1e-16 60.4 2.9 2.7 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 PIK58316.1 - 0.00013 21.9 0.4 0.00013 21.9 0.4 2.2 2 1 0 2 2 2 1 Sugar efflux transporter for intercellular exchange TSP_1 PF00090.19 PIK58317.1 - 4.3e-56 186.9 92.5 1.2e-10 41.4 5.5 7.3 7 0 0 7 7 7 6 Thrombospondin type 1 domain Glyco_transf_49 PF13896.6 PIK58319.1 - 4.2e-50 171.0 0.1 5.5e-50 170.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_tranf_2_2 PF10111.9 PIK58319.1 - 0.00019 21.0 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Tankyrase_bdg_C PF15327.6 PIK58319.1 - 0.13 12.7 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Tankyrase binding protein C terminal domain ICAT PF06384.11 PIK58320.1 - 9.8e-28 96.2 0.8 9.8e-28 96.2 0.8 2.1 2 1 0 2 2 2 1 Beta-catenin-interacting protein ICAT CAMP_factor PF07373.11 PIK58320.1 - 3.7e-05 23.4 1.5 6.9e-05 22.5 1.5 1.4 1 0 0 1 1 1 1 CAMP factor (Cfa) TMCO5 PF14992.6 PIK58320.1 - 0.0065 16.1 7.9 0.0065 16.1 7.9 1.5 1 1 1 2 2 2 1 TMCO5 family FlxA PF14282.6 PIK58320.1 - 0.015 15.2 4.7 0.015 15.2 4.7 2.2 2 1 1 3 3 3 0 FlxA-like protein FCD PF07729.12 PIK58320.1 - 0.023 15.1 0.8 0.039 14.4 0.8 1.5 1 0 0 1 1 1 0 FCD domain TetR_C_7 PF14246.6 PIK58320.1 - 0.025 14.6 0.2 0.055 13.5 0.0 1.7 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain LuxC PF05893.14 PIK58320.1 - 0.051 12.6 1.0 0.072 12.1 1.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DASH_Hsk3 PF08227.11 PIK58320.1 - 0.16 12.4 2.8 2.7 8.4 0.4 3.4 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like GvpG PF05120.12 PIK58320.1 - 0.18 11.8 11.3 0.29 11.2 0.1 2.4 2 0 0 2 2 2 0 Gas vesicle protein G DUF2408 PF10303.9 PIK58320.1 - 0.57 10.8 10.2 0.21 12.2 5.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) MutS_III PF05192.18 PIK58320.1 - 1 9.6 5.0 1.5 9.0 4.6 1.5 1 1 0 1 1 1 0 MutS domain III PilJ PF13675.6 PIK58320.1 - 1 9.4 6.6 15 5.6 0.2 3.1 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term LMBR1 PF04791.16 PIK58320.1 - 1.5 7.6 3.5 1.9 7.3 3.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF883 PF05957.13 PIK58320.1 - 2 9.0 9.6 1.6 9.4 2.1 3.4 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) CorA PF01544.18 PIK58320.1 - 2.3 7.5 7.2 6.2 6.1 7.1 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein NuA4 PF09340.10 PIK58320.1 - 5.1 7.0 6.4 14 5.7 0.0 2.7 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 Vir_act_alpha_C PF10400.9 PIK58320.1 - 5.7 7.7 9.6 10 6.9 4.4 3.0 1 1 1 2 2 2 0 Virulence activator alpha C-term Alk_phosphatase PF00245.20 PIK58321.1 - 4.3e-131 437.7 0.1 5.1e-131 437.5 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 PIK58321.1 - 2.3e-05 23.9 0.1 3.8e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 PIK58321.1 - 0.01 15.2 0.1 0.06 12.7 0.1 2.0 1 1 0 1 1 1 0 Sulfatase Phosphodiest PF01663.22 PIK58321.1 - 0.066 12.8 0.1 0.097 12.2 0.1 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase PPR_2 PF13041.6 PIK58321.1 - 0.18 12.0 0.0 0.44 10.8 0.0 1.6 1 0 0 1 1 1 0 PPR repeat family HTH_Tnp_Tc5 PF03221.16 PIK58322.1 - 0.001 19.1 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Cullin_Nedd8 PF10557.9 PIK58322.1 - 0.061 13.4 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Cullin protein neddylation domain PP2C PF00481.21 PIK58323.1 - 3.9e-56 190.5 0.0 4.4e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK58323.1 - 4.2e-06 26.6 0.0 8.3e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_8 PF01501.20 PIK58324.1 - 9.9e-05 22.0 0.1 0.00013 21.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 PI3_PI4_kinase PF00454.27 PIK58325.1 - 2.8e-61 207.5 0.3 1.3e-60 205.3 0.3 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 PIK58325.1 - 4.3e-41 140.4 0.2 7.2e-41 139.6 0.2 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 PIK58325.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI3K_p85B PF02192.16 PIK58326.1 - 3.8e-22 77.8 0.0 8.8e-22 76.6 0.0 1.7 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_C2 PF00792.24 PIK58326.1 - 5.1e-22 78.3 0.0 9.4e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 PIK58326.1 - 3.4e-14 52.9 0.1 7.6e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3Ka PF00613.20 PIK58326.1 - 0.018 14.4 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) IQ PF00612.27 PIK58327.1 - 1e-12 46.6 38.3 0.001 18.6 3.4 6.3 6 0 0 6 6 6 6 IQ calmodulin-binding motif DUF1473 PF07341.11 PIK58327.1 - 0.71 9.6 5.8 0.79 9.5 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1473) Ank_2 PF12796.7 PIK58328.1 - 9.4e-05 22.9 0.0 0.00031 21.3 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) TIG PF01833.24 PIK58328.1 - 0.0001 22.3 0.0 0.00027 21.0 0.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain Ank_5 PF13857.6 PIK58328.1 - 0.0022 18.2 0.1 3.1 8.2 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK58328.1 - 0.0061 17.0 0.7 1.6 9.3 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 PIK58328.1 - 0.0067 16.8 0.5 8.2 7.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat CG-1 PF03859.16 PIK58329.1 - 1.1e-09 38.1 1.1 1.9e-09 37.3 0.1 2.0 3 0 0 3 3 3 1 CG-1 domain DDOST_48kD PF03345.14 PIK58330.1 - 2.4e-115 385.7 0.0 3.2e-115 385.3 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta EMP24_GP25L PF01105.24 PIK58331.1 - 4.6e-09 36.5 0.0 5.2e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Noelin-1 PF12308.8 PIK58331.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Neurogenesis glycoprotein EMP24_GP25L PF01105.24 PIK58332.1 - 1.8e-17 63.9 1.0 2.3e-17 63.5 1.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD BspA_v PF18220.1 PIK58332.1 - 0.029 14.5 0.1 0.045 13.9 0.1 1.3 1 0 0 1 1 1 0 Adhesin BspA variable domain Ank_2 PF12796.7 PIK58333.1 - 2.3e-33 114.6 1.2 5.1e-15 55.8 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK58333.1 - 3.3e-22 78.5 1.1 4.7e-12 46.2 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK58333.1 - 2.4e-19 68.9 0.6 1.6e-05 25.2 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 PIK58333.1 - 3.8e-17 60.6 0.2 5e-05 23.4 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 PIK58333.1 - 3e-16 59.3 0.7 9e-10 38.6 0.2 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Trypan_glycop_C PF10659.9 PIK58334.1 - 0.0022 18.4 1.6 3.7 8.0 0.4 4.0 1 1 1 2 2 2 1 Trypanosome variant surface glycoprotein C-terminal domain DUF1864 PF08933.11 PIK58334.1 - 0.019 13.7 0.3 25 3.5 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF1864) PADR1 PF08063.12 PIK58334.1 - 0.26 11.1 7.1 63 3.5 0.0 4.9 6 0 0 6 6 6 0 PADR1 (NUC008) domain DUF3332 PF11810.8 PIK58334.1 - 0.56 9.8 7.2 4.9 6.8 2.0 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF3332) ubiquitin PF00240.23 PIK58335.1 - 8.2e-54 179.3 3.0 1.5e-27 95.1 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 PIK58335.1 - 3.7e-29 100.4 5.8 2.5e-14 52.9 1.1 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 PIK58335.1 - 8.8e-11 42.1 0.7 0.00014 22.2 0.0 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 PIK58335.1 - 6.9e-08 32.3 0.2 0.0046 16.9 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 PIK58335.1 - 2.1e-06 28.2 0.0 0.0097 16.5 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK58335.1 - 2.5e-06 27.6 0.1 0.003 17.6 0.0 2.7 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 PIK58335.1 - 0.0012 19.1 0.5 0.66 10.4 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain USP7_C2 PF14533.6 PIK58335.1 - 0.0051 16.5 0.6 0.18 11.5 0.2 2.2 1 1 1 2 2 2 1 Ubiquitin-specific protease C-terminal Ubiquitin_4 PF18036.1 PIK58335.1 - 0.02 14.9 6.1 5.7 7.0 0.0 3.9 2 2 2 4 4 4 0 Ubiquitin-like domain UN_NPL4 PF11543.8 PIK58335.1 - 0.034 14.6 0.0 8.5 6.9 0.0 2.4 1 1 1 2 2 2 0 Nuclear pore localisation protein NPL4 FERM_N PF09379.10 PIK58335.1 - 0.052 13.5 0.5 2.4 8.2 0.1 3.2 3 1 0 3 3 3 0 FERM N-terminal domain Polysacc_deac_3 PF15421.6 PIK58335.1 - 0.078 11.5 0.1 1.3 7.5 0.0 2.2 1 1 1 2 2 2 0 Putative polysaccharide deacetylase RRM_1 PF00076.22 PIK58336.1 - 1.9e-06 27.6 0.0 3.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 PIK58336.1 - 0.49 11.0 44.3 0.11 13.1 39.4 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Peptidase_M13_N PF05649.13 PIK58337.1 - 8.7e-80 269.2 2.1 1.1e-61 209.6 0.1 2.1 1 1 1 2 2 2 2 Peptidase family M13 DUF2304 PF10066.9 PIK58337.1 - 0.011 16.0 0.7 0.019 15.2 0.3 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) TnpW PF14202.6 PIK58337.1 - 0.03 14.2 0.2 0.091 12.6 0.1 1.9 2 0 0 2 2 2 0 Transposon-encoded protein TnpW GbpC PF08363.10 PIK58337.1 - 0.045 13.2 0.1 0.093 12.2 0.1 1.5 1 0 0 1 1 1 0 Glucan-binding protein C PPP1R35_C PF15503.6 PIK58338.1 - 1.6e-29 102.6 0.9 2.5e-29 101.9 0.5 1.5 2 0 0 2 2 2 1 Protein phosphatase 1 regulatory subunit 35 C-terminus WD40 PF00400.32 PIK58339.1 - 4.3e-17 62.2 9.2 6.8e-06 26.7 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat HEAT PF02985.22 PIK58339.1 - 3e-06 27.0 2.2 1.2 9.6 0.1 5.5 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 PIK58339.1 - 0.0053 17.1 0.3 7.1 7.1 0.0 3.2 2 1 1 3 3 3 2 HEAT repeats Cas_Csy4 PF09618.10 PIK58339.1 - 0.028 14.6 0.0 0.064 13.4 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) ANAPC4_WD40 PF12894.7 PIK58339.1 - 0.033 14.5 0.2 5.7 7.3 0.0 3.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 PIK58340.1 - 2e-16 60.1 0.0 7.6e-12 45.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58340.1 - 5e-07 29.3 0.0 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 PIK58340.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Alk_phosphatase PF00245.20 PIK58341.1 - 5.6e-141 470.2 0.2 1.7e-83 280.9 0.2 2.0 1 1 1 2 2 2 2 Alkaline phosphatase Metalloenzyme PF01676.18 PIK58341.1 - 6.2e-05 22.5 0.0 8.6e-05 22.0 0.0 1.4 1 1 0 1 1 1 1 Metalloenzyme superfamily Methyltranf_PUA PF13636.6 PIK58341.1 - 0.025 14.6 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 RNA-binding PUA-like domain of methyltransferase RsmF DeoRC PF00455.22 PIK58341.1 - 0.028 14.3 0.4 13 5.7 0.0 2.7 3 0 0 3 3 3 0 DeoR C terminal sensor domain acVLRF1 PF18859.1 PIK58341.1 - 0.088 13.1 0.0 22 5.4 0.0 2.4 2 0 0 2 2 2 0 Actinobacteria/chloroflexi VLRF1 release factor Terpene_synth PF01397.21 PIK58341.1 - 0.18 11.5 0.0 23 4.6 0.0 2.2 2 0 0 2 2 2 0 Terpene synthase, N-terminal domain Alk_phosphatase PF00245.20 PIK58342.1 - 1.7e-12 47.0 0.0 2.1e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Alk_phosphatase PF00245.20 PIK58343.1 - 5.7e-142 473.5 0.0 6.6e-142 473.3 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 PIK58343.1 - 0.0018 17.7 0.2 0.003 17.0 0.2 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily RUN PF02759.19 PIK58344.1 - 2.4e-11 43.7 4.2 2.5e-11 43.7 0.6 2.8 3 0 0 3 3 3 1 RUN domain PH PF00169.29 PIK58344.1 - 2.4e-07 31.2 0.6 2.4e-07 31.2 0.6 3.6 4 0 0 4 4 4 1 PH domain Myosin_TH1 PF06017.13 PIK58344.1 - 1.1e-06 28.5 1.0 0.00031 20.5 0.2 2.6 2 0 0 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 PIK58344.1 - 0.0043 16.8 0.3 0.064 13.0 0.1 2.3 2 0 0 2 2 2 1 Inositol phosphatase PH_9 PF15410.6 PIK58344.1 - 0.066 13.6 0.0 0.63 10.4 0.0 2.6 1 1 1 2 2 2 0 Pleckstrin homology domain His_Phos_2 PF00328.22 PIK58345.1 - 4.6e-23 82.2 1.7 1.2e-22 80.9 0.0 2.3 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) DUF4820 PF16091.5 PIK58345.1 - 3.5 6.9 7.2 6.1 6.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Laminin_G_3 PF13385.6 PIK58346.1 - 0.0015 18.7 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_16 PF00722.21 PIK58346.1 - 0.0094 15.4 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Laminin_G_2 PF02210.24 PIK58346.1 - 0.0095 16.5 0.0 0.022 15.3 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain 7tm_3 PF00003.22 PIK58346.1 - 0.063 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR FAM176 PF14851.6 PIK58346.1 - 0.075 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 FAM176 family DUF4448 PF14610.6 PIK58346.1 - 0.096 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) T2SSF PF00482.23 PIK58346.1 - 0.23 11.4 0.1 0.44 10.5 0.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF1180 PF06679.12 PIK58346.1 - 0.54 10.7 3.1 1.3 9.5 3.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) RPAP2_Rtr1 PF04181.13 PIK58347.1 - 0.018 15.3 0.1 0.027 14.8 0.1 1.3 1 0 0 1 1 1 0 Rtr1/RPAP2 family Cadherin PF00028.17 PIK58348.1 - 2e-12 47.4 0.0 9.4e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 Cadherin domain PseudoU_synth_1 PF01416.20 PIK58349.1 - 2.6e-17 63.2 0.0 5.7e-16 58.9 0.0 2.3 2 1 0 2 2 2 1 tRNA pseudouridine synthase PTN_MK_C PF01091.18 PIK58349.1 - 0.066 13.6 0.7 0.13 12.6 0.7 1.4 1 0 0 1 1 1 0 PTN/MK heparin-binding protein family, C-terminal domain FlxA PF14282.6 PIK58349.1 - 0.12 12.4 0.8 0.2 11.7 0.8 1.3 1 0 0 1 1 1 0 FlxA-like protein eIF2A PF08662.11 PIK58350.1 - 1.9e-11 44.2 0.2 0.016 15.1 0.0 3.7 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 PIK58350.1 - 2.4e-09 37.4 5.2 0.0074 16.6 0.2 5.6 2 2 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK58350.1 - 2.4e-08 34.5 5.2 1.2 10.1 0.1 7.0 7 0 0 7 7 7 2 WD domain, G-beta repeat DPPIV_N PF00930.21 PIK58350.1 - 0.00014 20.8 2.8 0.18 10.5 0.0 4.3 3 1 1 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 PIK58350.1 - 0.00038 20.3 0.1 7.5 6.6 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 PIK58350.1 - 0.0017 16.5 1.7 0.69 7.8 0.1 3.5 2 2 2 4 4 4 2 IKI3 family Lactonase PF10282.9 PIK58350.1 - 0.12 11.6 0.0 3.6 6.8 0.0 2.8 1 1 2 3 3 3 0 Lactonase, 7-bladed beta-propeller Proteasome_A_N PF10584.9 PIK58350.1 - 0.15 11.8 0.2 37 4.1 0.0 4.3 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature HSF_DNA-bind PF00447.17 PIK58350.1 - 0.22 12.2 1.2 6 7.6 0.1 3.7 4 2 3 7 7 7 0 HSF-type DNA-binding Guanylate_cyc PF00211.20 PIK58351.1 - 3.9e-33 114.6 0.3 8.4e-32 110.3 0.0 2.2 1 1 1 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain NIT PF08376.10 PIK58351.1 - 5.4e-09 36.8 0.1 9.6e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Nitrate and nitrite sensing HNOBA PF07701.14 PIK58351.1 - 0.00016 21.1 0.2 0.00026 20.5 0.2 1.2 1 0 0 1 1 1 1 Heme NO binding associated Spore_III_AB PF09548.10 PIK58351.1 - 0.035 14.2 0.1 0.078 13.1 0.1 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) MLANA PF14991.6 PIK58351.1 - 0.15 12.3 1.0 5.6 7.3 0.2 2.4 2 0 0 2 2 2 0 Protein melan-A TrbC PF04956.13 PIK58351.1 - 0.18 12.1 1.4 0.27 11.5 0.3 1.8 2 0 0 2 2 2 0 TrbC/VIRB2 family Sulfotransfer_2 PF03567.14 PIK58352.1 - 1.1e-11 45.2 0.1 1.9e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK58352.1 - 0.052 13.0 0.8 0.078 12.4 0.0 1.6 2 0 0 2 2 2 0 Sulfotransferase domain DUF3481 PF11980.8 PIK58352.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein 7tm_1 PF00001.21 PIK58353.1 - 2.6e-27 95.8 18.2 3.8e-27 95.3 18.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58353.1 - 1.3e-10 41.1 18.8 1.3e-10 41.1 18.8 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK58353.1 - 1.9e-09 37.6 21.7 1.9e-09 37.6 21.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK58353.1 - 2.3e-08 33.7 11.2 2.3e-08 33.7 11.2 2.7 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srv SP_C-Propep PF08999.10 PIK58353.1 - 0.098 12.5 0.1 0.098 12.5 0.1 3.2 4 1 1 5 5 5 0 Surfactant protein C, N terminal propeptide EphA2_TM PF14575.6 PIK58353.1 - 5.6 7.9 0.0 5.6 7.9 0.0 3.8 5 0 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain RRM_1 PF00076.22 PIK58354.1 - 4.3e-27 93.7 0.2 1.4e-12 47.2 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TDP43_N PF18694.1 PIK58354.1 - 7.2e-26 89.8 0.0 1.2e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_7 PF16367.5 PIK58354.1 - 7.3e-06 26.0 0.1 0.13 12.4 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK58354.1 - 0.00015 21.7 0.1 0.033 14.2 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 PIK58354.1 - 0.0012 18.7 0.1 0.35 10.9 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 PIK58354.1 - 0.0096 15.8 0.0 0.51 10.3 0.0 2.2 2 0 0 2 2 2 1 RL domain Ish1 PF10281.9 PIK58354.1 - 0.033 14.5 0.2 5.6 7.4 0.0 2.8 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein OB_RNB PF08206.11 PIK58354.1 - 0.057 13.1 0.3 5.3 6.8 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain Mod_r PF07200.13 PIK58356.1 - 0.0096 16.0 1.5 0.017 15.2 1.5 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein KfrA_N PF11740.8 PIK58356.1 - 0.2 12.4 1.9 0.37 11.5 1.5 1.7 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term NACHT PF05729.12 PIK58357.1 - 1.3e-11 44.7 0.0 3.2e-11 43.4 0.0 1.6 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK58357.1 - 6.2e-06 25.9 0.0 0.0057 16.3 0.0 2.6 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 PIK58357.1 - 0.0053 17.1 0.6 0.42 11.0 0.1 3.4 1 1 2 3 3 3 1 RNA helicase ER PF01133.17 PIK58357.1 - 0.035 14.1 0.8 0.1 12.7 0.1 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary AAA_22 PF13401.6 PIK58357.1 - 0.039 14.2 0.0 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 PIK58357.1 - 0.07 13.6 0.0 0.19 12.2 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PaaX PF07848.12 PIK58358.1 - 0.013 15.7 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 PaaX-like protein Transp_Tc5_C PF04236.15 PIK58359.1 - 0.14 12.6 4.3 0.29 11.5 4.3 1.5 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain RVT_1 PF00078.27 PIK58360.1 - 2.3e-19 69.8 0.0 6.3e-19 68.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK58360.1 - 0.026 14.4 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Med18 protein zf-C3HC4_2 PF13923.6 PIK58361.1 - 4.6e-07 29.6 9.2 1e-06 28.5 9.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.20 PIK58361.1 - 3.2e-06 27.1 2.8 7e-06 26.0 2.8 1.5 1 0 0 1 1 1 1 Region in Clathrin and VPS zf-RING_2 PF13639.6 PIK58361.1 - 4.1e-06 27.0 8.7 1e-05 25.8 8.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 PIK58361.1 - 7.2e-05 23.0 4.5 0.0002 21.6 4.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 PIK58361.1 - 0.00024 21.0 7.9 0.0005 20.0 7.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK58361.1 - 0.0022 17.8 8.6 0.0047 16.8 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 PIK58361.1 - 0.0047 17.4 3.1 0.012 16.0 3.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-C3H2C3 PF17122.5 PIK58361.1 - 0.0091 16.0 11.5 0.019 15.0 11.5 1.6 1 0 0 1 1 1 1 Zinc-finger Zn_ribbon_17 PF17120.5 PIK58361.1 - 0.021 14.4 7.2 0.046 13.4 7.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 PIK58361.1 - 0.036 14.1 8.9 0.11 12.5 8.9 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK58361.1 - 0.068 13.0 5.9 0.13 12.2 5.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) VPS11_C PF12451.8 PIK58361.1 - 0.087 13.1 1.2 0.28 11.4 1.2 1.9 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal zf-RING-like PF08746.11 PIK58361.1 - 1.4 9.3 9.2 5.4 7.4 9.2 2.1 1 1 0 1 1 1 0 RING-like domain zf-C3HC4_4 PF15227.6 PIK58361.1 - 6.4 7.0 11.5 5.8 7.2 9.9 1.8 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING RT_RNaseH PF17917.1 PIK58362.1 - 3.6e-30 104.3 0.0 7.3e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58362.1 - 1.3e-26 92.5 0.0 2.8e-26 91.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK58362.1 - 1.1e-15 57.5 0.3 3.6e-15 55.8 0.3 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK58362.1 - 0.0059 16.8 0.1 0.022 15.0 0.1 2.0 1 0 0 1 1 1 1 H2C2 zinc finger SET PF00856.28 PIK58363.1 - 1.7e-15 57.9 0.5 6.2e-15 56.0 0.5 1.7 1 1 0 1 1 1 1 SET domain PTS_EIIB PF00367.20 PIK58363.1 - 0.049 13.1 1.5 0.088 12.3 0.6 1.9 2 0 0 2 2 2 0 phosphotransferase system, EIIB TIMELESS PF04821.14 PIK58364.1 - 2.3e-54 184.5 2.4 6.7e-31 107.6 0.7 2.1 1 1 1 2 2 2 2 Timeless protein Peptidase_S24 PF00717.23 PIK58365.1 - 7.5e-10 38.6 0.1 1.3e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like Zwilch PF09817.9 PIK58366.1 - 6.3e-41 140.5 1.4 8.1e-41 140.1 1.4 1.1 1 0 0 1 1 1 1 RZZ complex, subunit zwilch Ribosomal_L4 PF00573.22 PIK58367.1 - 9.4e-20 71.1 0.1 3.1e-19 69.4 0.1 1.7 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family DUF3127 PF11325.8 PIK58368.1 - 0.0033 17.6 0.1 0.0077 16.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3127) AAA_30 PF13604.6 PIK58368.1 - 0.075 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.17 PIK58369.1 - 5.9e-43 147.0 0.0 9.4e-43 146.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58369.1 - 5.7e-26 91.4 0.0 1.1e-25 90.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK58369.1 - 7.3e-24 84.2 0.5 4.8e-09 36.7 0.0 6.0 6 0 0 6 6 6 4 Immunoglobulin domain I-set PF07679.16 PIK58369.1 - 2.4e-14 53.2 0.0 3.4e-08 33.4 0.0 4.5 5 0 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK58369.1 - 2.8e-13 50.0 0.7 1.7e-05 25.1 0.0 6.1 6 0 0 6 6 6 2 Immunoglobulin domain ig PF00047.25 PIK58369.1 - 3.4e-12 46.3 0.9 0.00011 22.3 0.0 5.5 6 1 0 6 6 6 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK58369.1 - 7.2e-07 29.2 0.4 0.43 10.7 0.0 4.9 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK58369.1 - 0.00051 20.2 0.1 0.035 14.3 0.0 3.7 3 1 0 3 3 3 1 Immunoglobulin V-set domain RVT_1 PF00078.27 PIK58370.1 - 3.6e-38 131.3 0.1 6.7e-38 130.4 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK58370.1 - 0.00034 20.4 1.2 0.37 10.6 0.0 3.1 3 0 0 3 3 3 2 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK58372.1 - 1.7e-26 93.2 0.1 2.7e-26 92.4 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK58372.1 - 0.0005 19.9 0.1 0.0012 18.6 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase V-set PF07686.17 PIK58373.1 - 6.7e-05 23.0 0.1 8.9e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK58373.1 - 0.0016 19.0 0.3 0.0037 17.8 0.3 1.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK58373.1 - 0.017 15.3 0.3 0.05 13.8 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Fibrinogen_C PF00147.18 PIK58374.1 - 5.9e-12 45.9 3.7 1.2e-05 25.2 0.2 2.4 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58374.1 - 0.0019 18.1 1.7 0.0019 18.1 1.7 2.7 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK58374.1 - 4 7.7 15.0 1.3 9.3 4.8 3.7 2 2 0 2 2 2 0 EGF domain Fibrinogen_C PF00147.18 PIK58375.1 - 6.5e-26 91.5 2.9 3e-19 69.7 0.0 2.6 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK58375.1 - 5.2e-05 23.4 6.3 5.2e-05 23.4 6.3 3.5 4 1 1 5 5 5 1 EGF domain TILa PF12714.7 PIK58375.1 - 0.00013 21.9 4.9 0.00013 21.9 4.9 2.9 1 1 1 2 2 2 1 TILa domain RVT_1 PF00078.27 PIK58376.1 - 2.3e-41 141.7 0.1 3.5e-41 141.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CotJB PF12652.7 PIK58376.1 - 0.18 12.1 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 CotJB protein Fibrinogen_C PF00147.18 PIK58377.1 - 7.8e-34 117.4 0.1 1.1e-33 116.9 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58377.1 - 2.9e-07 30.6 17.5 2.9e-07 30.6 17.5 2.3 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK58378.1 - 7e-48 163.3 2.0 8.4e-40 136.9 0.3 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58378.1 - 5.9e-07 29.6 18.8 5.9e-07 29.6 18.8 3.7 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58378.1 - 0.00019 21.6 9.9 0.00019 21.6 9.9 4.5 5 0 0 5 5 5 1 EGF domain TILa PF12714.7 PIK58378.1 - 0.0002 21.2 4.5 0.0002 21.2 4.5 3.2 2 1 2 4 4 4 1 TILa domain EGF_Tenascin PF18720.1 PIK58378.1 - 0.17 12.0 0.1 0.17 12.0 0.1 5.4 5 1 0 5 5 5 0 Tenascin EGF domain zf-H2C2_5 PF13909.6 PIK58379.1 - 6.6e-05 22.6 0.9 0.00016 21.3 0.9 1.7 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 PIK58379.1 - 0.0084 16.5 0.6 0.026 14.9 0.6 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 PIK58379.1 - 0.08 13.6 2.9 4 8.2 0.3 2.8 1 1 1 2 2 2 0 FOXP coiled-coil domain zf_C2H2_ZHX PF18387.1 PIK58379.1 - 0.096 12.3 0.4 0.57 9.9 0.1 2.3 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Formyl_trans_C PF02911.18 PIK58379.1 - 0.13 12.5 0.5 1.5 9.1 0.1 2.7 3 1 0 3 3 3 0 Formyl transferase, C-terminal domain DUF3716 PF12511.8 PIK58379.1 - 0.18 11.9 1.9 0.37 10.9 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) zf-C2H2_4 PF13894.6 PIK58379.1 - 0.21 12.5 0.6 0.79 10.7 0.5 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger RT_RNaseH_2 PF17919.1 PIK58380.1 - 2.7e-37 126.8 0.0 5.3e-37 125.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58380.1 - 1.1e-24 86.7 0.0 3.5e-24 85.1 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58380.1 - 4.1e-23 82.1 0.0 1.6e-16 60.5 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK58380.1 - 3.8e-20 71.8 2.0 1.1e-19 70.3 2.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain Spuma_A9PTase PF03539.14 PIK58380.1 - 0.00059 20.0 0.2 0.0031 17.6 0.0 2.3 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) zf-H2C2 PF09337.10 PIK58380.1 - 0.0026 17.9 0.1 0.011 16.0 0.1 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Fibrinogen_C PF00147.18 PIK58381.1 - 1.6e-15 57.5 3.2 1.8e-15 57.3 3.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK58382.1 - 1.4e-23 83.8 3.0 1.5e-23 83.7 3.0 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK58383.1 - 1.3e-64 218.0 9.1 1.7e-64 217.6 9.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK58383.1 - 0.00048 19.5 0.1 0.00068 19.0 0.1 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain EGF_3 PF12947.7 PIK58383.1 - 0.21 11.8 4.5 0.12 12.6 1.9 2.0 2 0 0 2 2 2 0 EGF domain Phage_integrase PF00589.22 PIK58384.1 - 0.0038 17.0 0.0 0.009 15.8 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family TPMT PF05724.11 PIK58385.1 - 0.059 13.0 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) RT_RNaseH PF17917.1 PIK58386.1 - 0.047 14.0 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Raftlin PF15250.6 PIK58387.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Raftlin Fibrinogen_C PF00147.18 PIK58389.1 - 4.4e-49 167.3 8.7 2.9e-37 128.6 2.3 3.2 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58389.1 - 8.7e-08 32.3 17.4 8.7e-08 32.3 17.4 3.7 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58389.1 - 0.00041 20.5 10.5 0.00041 20.5 10.5 4.2 4 0 0 4 4 4 1 EGF domain TILa PF12714.7 PIK58389.1 - 0.00099 19.0 5.1 0.00099 19.0 5.1 3.2 3 1 1 4 4 4 1 TILa domain EGF_Tenascin PF18720.1 PIK58389.1 - 0.012 15.6 0.2 0.012 15.6 0.2 5.2 5 1 1 6 6 6 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK58390.1 - 3.5e-38 131.6 0.9 4.9e-38 131.1 0.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK58390.1 - 0.00042 19.7 0.1 0.00058 19.2 0.1 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain EGF_3 PF12947.7 PIK58390.1 - 5.4 7.3 8.8 2.9 8.1 6.0 2.1 2 0 0 2 2 2 0 EGF domain Fibrinogen_C PF00147.18 PIK58391.1 - 5.8e-102 340.2 15.2 2.6e-61 207.3 10.3 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58391.1 - 1.4e-07 31.7 17.9 1.4e-07 31.7 17.9 3.5 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain COLFI PF01410.18 PIK58391.1 - 5.2e-07 29.2 2.9 0.00011 21.6 0.6 2.4 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK58391.1 - 0.00017 21.4 5.4 0.00017 21.4 5.4 3.3 2 1 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK58391.1 - 0.0003 20.9 9.9 0.0003 20.9 9.9 3.8 4 0 0 4 4 4 1 EGF domain EGF_Tenascin PF18720.1 PIK58391.1 - 0.032 14.3 0.7 0.032 14.3 0.7 5.4 6 1 0 6 6 6 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK58393.1 - 5.9e-15 55.7 0.2 2.4e-07 30.8 0.1 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58393.1 - 1.5e-07 31.5 18.3 1.5e-07 31.5 18.3 3.2 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain COLFI PF01410.18 PIK58393.1 - 3.1e-05 23.4 0.3 6.6e-05 22.3 0.3 1.5 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK58393.1 - 0.00017 21.5 4.2 0.00017 21.5 4.2 3.2 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK58393.1 - 0.00018 21.7 8.6 0.00018 21.7 8.6 3.7 4 1 0 4 4 4 1 EGF domain EGF_Tenascin PF18720.1 PIK58393.1 - 0.18 11.9 0.3 0.18 11.9 0.3 5.0 5 2 0 5 5 5 0 Tenascin EGF domain Fibrinogen_C PF00147.18 PIK58394.1 - 2e-35 122.6 0.1 2.4e-35 122.3 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58394.1 - 3.1e-06 27.4 20.5 5.6e-06 26.5 20.5 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Calcyon PF06387.11 PIK58394.1 - 0.23 11.4 1.2 0.38 10.7 1.2 1.3 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Fibrinogen_C PF00147.18 PIK58395.1 - 9e-63 212.0 9.1 1.2e-62 211.6 9.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58395.1 - 1.3e-06 28.5 13.6 1.3e-06 28.5 13.6 3.4 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain COLFI PF01410.18 PIK58395.1 - 1e-05 25.0 0.1 1.6e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK58395.1 - 3.7e-05 23.6 2.5 3.7e-05 23.6 2.5 3.3 2 1 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK58395.1 - 0.00021 21.4 5.8 0.00021 21.4 5.8 3.4 3 1 0 3 3 3 1 EGF domain cEGF PF12662.7 PIK58395.1 - 0.27 11.2 8.7 3.9 7.5 2.5 3.5 2 0 0 2 2 2 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK58396.1 - 5.3e-33 114.7 0.1 6.6e-33 114.4 0.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK58397.1 - 1.7e-27 96.4 0.4 2e-27 96.2 0.4 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TraT PF05818.12 PIK58397.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein TIL PF01826.17 PIK58398.1 - 8.3e-07 29.2 16.8 8.3e-07 29.2 16.8 3.3 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK58398.1 - 6.6e-06 26.1 0.1 1.5e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK58398.1 - 0.0013 18.9 8.1 0.0013 18.9 8.1 3.1 3 0 0 3 3 3 1 EGF domain COLFI PF01410.18 PIK58398.1 - 0.0016 17.8 0.3 0.0036 16.6 0.3 1.5 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain TILa PF12714.7 PIK58398.1 - 0.0023 17.8 1.5 0.0023 17.8 1.5 3.0 2 1 0 2 2 2 1 TILa domain cEGF PF12662.7 PIK58398.1 - 0.2 11.6 11.7 0.96 9.4 4.0 3.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK58399.1 - 1.6e-29 103.3 0.1 9.1e-28 97.6 0.0 2.2 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58399.1 - 2.1e-07 31.1 17.3 2.1e-07 31.1 17.3 3.4 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58399.1 - 9.8e-05 22.5 7.2 9.8e-05 22.5 7.2 3.6 3 1 0 3 3 3 1 EGF domain TILa PF12714.7 PIK58399.1 - 0.00025 20.9 3.6 0.00025 20.9 3.6 2.8 2 1 0 2 2 2 1 TILa domain cEGF PF12662.7 PIK58399.1 - 0.022 14.7 11.7 0.49 10.4 4.0 3.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_Tenascin PF18720.1 PIK58399.1 - 0.16 12.0 0.3 0.16 12.0 0.3 4.8 3 2 1 4 4 4 0 Tenascin EGF domain FERM_C PF09380.10 PIK58400.1 - 3.2e-27 94.8 0.0 9.4e-27 93.2 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 PIK58400.1 - 1.4e-26 93.2 0.3 1.4e-26 93.2 0.3 2.8 2 1 1 3 3 3 1 FERM central domain ERM PF00769.19 PIK58400.1 - 6.5e-05 22.9 50.5 6.5e-05 22.9 50.5 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family DUF737 PF05300.11 PIK58400.1 - 0.11 12.8 27.9 0.21 11.9 27.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Radial_spoke_3 PF06098.11 PIK58401.1 - 8.8e-131 435.4 9.3 8.8e-131 435.4 9.3 2.0 2 0 0 2 2 2 1 Radial spoke protein 3 DUF2866 PF11065.8 PIK58401.1 - 0.16 12.0 0.7 0.59 10.2 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) V_ATPase_I PF01496.19 PIK58401.1 - 2.9 5.7 7.0 4.6 5.0 7.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-C2H2 PF00096.26 PIK58402.1 - 3e-16 58.9 22.5 4.8e-05 23.6 1.8 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58402.1 - 8.7e-14 51.1 19.8 0.0056 17.4 1.3 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK58402.1 - 8.8e-11 41.7 17.4 0.00023 21.5 0.4 5.7 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK58402.1 - 1.6e-05 25.1 5.7 0.19 12.1 0.0 4.7 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK58402.1 - 1.9e-05 24.9 3.1 3.3 8.2 0.0 4.2 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK58402.1 - 0.00077 19.4 15.1 0.0024 17.9 0.9 3.3 3 0 0 3 3 3 2 BED zinc finger SET PF00856.28 PIK58402.1 - 0.002 18.6 0.0 0.55 10.6 0.0 3.0 2 1 0 2 2 2 1 SET domain zf-C2H2_2 PF12756.7 PIK58402.1 - 0.025 14.9 6.3 13 6.2 0.5 4.2 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) C1_1 PF00130.22 PIK58402.1 - 0.1 12.5 5.4 15 5.5 0.4 3.6 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_5 PF13909.6 PIK58402.1 - 0.13 12.0 12.0 5.7 6.8 3.3 4.3 3 1 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_12 PF18658.1 PIK58402.1 - 0.14 11.7 2.1 1 9.0 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 PIK58402.1 - 1.2 8.8 3.8 8.6 6.1 0.0 3.0 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain NPR1_interact PF15699.5 PIK58402.1 - 1.6 9.4 7.0 0.76 10.4 1.3 2.5 2 1 1 3 3 3 0 NPR1 interacting PyrI_C PF02748.15 PIK58402.1 - 3.1 7.8 5.7 6.7 6.7 0.1 3.0 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 PIK58402.1 - 4.5 7.4 18.6 6.7 6.8 2.0 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger FYVE PF01363.21 PIK58402.1 - 6.1 7.1 8.0 1.1e+02 3.0 0.1 3.5 2 1 0 2 2 2 0 FYVE zinc finger Methyltransf_22 PF13383.6 PIK58403.1 - 1.2e-07 31.6 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Mago_nashi PF02792.14 PIK58404.1 - 8.9e-77 256.0 0.3 9.9e-77 255.9 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein Cornifin PF02389.15 PIK58405.1 - 2.4e-13 50.4 18.9 1.3e-07 31.8 8.3 2.4 1 1 1 2 2 2 2 Cornifin (SPRR) family DUF1388 PF07142.12 PIK58405.1 - 4.6e-06 26.5 40.3 1.8e+04 -23.6 40.3 8.1 1 1 0 1 1 1 0 Repeat of unknown function (DUF1388) MAP7 PF05672.11 PIK58406.1 - 0.0048 16.6 70.5 0.0048 16.6 70.5 4.2 2 2 0 3 3 3 1 MAP7 (E-MAP-115) family NOZZLE PF08744.10 PIK58407.1 - 0.0059 16.2 0.8 0.0072 15.9 0.8 1.2 1 0 0 1 1 1 1 Plant transcription factor NOZZLE RAM PF15320.6 PIK58407.1 - 2 9.0 10.7 56 4.4 8.8 2.9 2 1 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein SKA1 PF07160.12 PIK58408.1 - 3.1e-05 24.0 0.2 3.1e-05 24.0 0.2 2.4 2 1 0 2 2 2 2 Spindle and kinetochore-associated protein 1 Sod_Fe_C PF02777.18 PIK58409.1 - 3.2e-37 126.8 0.0 5.6e-37 126.0 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 PIK58409.1 - 2.8e-29 101.4 0.6 5e-29 100.6 0.6 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Wtap PF17098.5 PIK58410.1 - 9.4e-52 175.1 16.8 1.1e-51 174.8 14.6 2.4 2 0 0 2 2 2 1 WTAP/Mum2p family DUF3810 PF12725.7 PIK58410.1 - 5.9 6.1 5.2 1.4 8.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF3665 PF12427.8 PIK58410.1 - 6.3 6.6 5.6 1.4 8.7 0.3 2.7 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase Calcipressin PF04847.12 PIK58411.1 - 1.5e-29 103.1 0.2 1.5e-29 103.1 0.2 1.9 2 1 0 2 2 2 1 Calcipressin 7tm_1 PF00001.21 PIK58412.1 - 1.1e-12 47.8 0.2 1.6e-12 47.4 0.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58412.1 - 3.8e-07 29.8 0.6 4.8e-07 29.4 0.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sre PF03125.18 PIK58412.1 - 4.9e-05 22.6 0.9 6.1e-05 22.3 0.9 1.0 1 0 0 1 1 1 1 C. elegans Sre G protein-coupled chemoreceptor TRAPP PF04051.16 PIK58413.1 - 1.8e-37 128.3 0.0 2.3e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Coprogen_oxidas PF01218.18 PIK58414.1 - 5.6e-142 471.8 0.0 6.7e-142 471.5 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase PAE PF03283.13 PIK58415.1 - 9.5e-70 235.5 0.6 1.9e-68 231.2 0.6 2.2 1 1 0 1 1 1 1 Pectinacetylesterase Peptidase_S9 PF00326.21 PIK58415.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Creatinase_N_2 PF16189.5 PIK58417.1 - 9.1e-43 146.1 0.0 1.7e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 PIK58417.1 - 1.8e-37 129.0 0.0 3.7e-37 128.1 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 PIK58417.1 - 3.3e-17 62.3 0.6 7.2e-17 61.2 0.1 1.9 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 PIK58417.1 - 4e-15 56.6 0.0 6.6e-11 43.0 0.0 2.6 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Snf7 PF03357.21 PIK58418.1 - 2.4e-35 121.7 30.9 2.4e-35 121.7 30.9 1.7 2 0 0 2 2 2 1 Snf7 DnaJ-X PF14308.6 PIK58418.1 - 0.0025 17.3 13.7 0.0025 17.3 13.7 1.9 1 1 1 2 2 2 1 X-domain of DnaJ-containing Peptidase_S64 PF08192.11 PIK58418.1 - 5.6 5.3 17.2 5.5 5.4 17.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 SAM_2 PF07647.17 PIK58419.1 - 2.6e-31 107.5 0.5 1.1e-09 38.2 0.0 4.3 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK58419.1 - 2.6e-29 101.4 0.3 2.9e-10 40.4 0.0 3.9 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) NCD1 PF04904.13 PIK58419.1 - 2.8e-06 27.2 0.2 0.055 13.5 0.0 3.8 3 0 0 3 3 3 2 NAB conserved region 1 (NCD1) SH3_2 PF07653.17 PIK58419.1 - 0.00036 20.1 0.0 0.00075 19.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Npa1 PF11707.8 PIK58420.1 - 5.3e-54 183.8 13.5 4.9e-53 180.7 1.7 3.7 3 0 0 3 3 3 3 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 PIK58420.1 - 7.2e-44 149.8 2.7 1e-43 149.2 0.0 2.8 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Glyco_hydro_99 PF16317.5 PIK58421.1 - 7.4e-139 462.7 8.9 7.4e-139 462.7 8.9 1.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 99 tRNA-synt_1d PF00750.19 PIK58422.1 - 2.3e-98 329.4 0.9 3.2e-98 328.9 0.9 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 PIK58422.1 - 9.7e-22 77.4 0.4 2.9e-21 75.8 0.4 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain DUF4162 PF13732.6 PIK58422.1 - 0.11 13.2 0.4 0.61 10.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) Ig_3 PF13927.6 PIK58423.1 - 5.3e-08 33.4 0.2 0.00015 22.3 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK58423.1 - 9.8e-08 32.1 0.1 7.5e-07 29.3 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58423.1 - 0.00037 20.5 0.6 0.021 14.9 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin I-set domain LST1 PF05083.13 PIK58423.1 - 0.0018 18.5 0.1 0.008 16.4 0.0 2.1 2 0 0 2 2 2 1 LST-1 protein ig PF00047.25 PIK58423.1 - 0.0022 18.1 4.1 0.01 16.0 0.2 3.4 3 1 1 4 4 4 1 Immunoglobulin domain Comm PF15957.5 PIK58423.1 - 0.0031 17.8 0.0 0.084 13.2 0.0 2.5 2 0 0 2 2 2 1 Commissureless Ig_2 PF13895.6 PIK58423.1 - 0.024 15.0 5.2 4.6 7.6 0.6 3.7 2 1 1 3 3 3 0 Immunoglobulin domain Nairovirus_M PF07948.11 PIK58423.1 - 0.09 11.0 0.1 0.14 10.4 0.1 1.2 1 0 0 1 1 1 0 Nairovirus M polyprotein-like Orthoreo_P10 PF07204.11 PIK58423.1 - 0.1 12.6 0.1 0.1 12.6 0.1 1.7 2 0 0 2 2 1 0 Orthoreovirus membrane fusion protein p10 WBP-1 PF11669.8 PIK58423.1 - 0.12 13.0 0.0 1.7 9.3 0.0 2.5 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF997 PF06196.12 PIK58423.1 - 1.2 9.2 4.3 1.2 9.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF997) Ig_3 PF13927.6 PIK58424.1 - 1.5e-17 64.0 3.2 2.1e-09 37.9 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK58424.1 - 2.1e-11 43.9 0.2 2.7e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK58424.1 - 3.7e-11 43.2 2.0 0.0002 21.6 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK58424.1 - 1e-10 41.5 0.0 4.4e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 PIK58424.1 - 2.8e-06 27.5 0.1 2.8e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain EphA2_TM PF14575.6 PIK58424.1 - 0.034 15.0 0.0 0.034 15.0 0.0 2.3 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK58424.1 - 0.31 10.9 2.3 0.21 11.5 0.2 1.8 2 0 0 2 2 2 0 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK58424.1 - 1.8 8.2 12.0 1.4 8.5 8.9 2.4 1 1 1 2 2 2 0 Baculovirus 11 kDa family Orf78 PF06024.12 PIK58424.1 - 2.9 8.3 6.4 0.31 11.3 1.1 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Ig_3 PF13927.6 PIK58425.1 - 1.4e-08 35.2 0.2 1.3e-05 25.7 0.0 4.2 4 0 0 4 4 4 1 Immunoglobulin domain ig PF00047.25 PIK58425.1 - 6.5e-05 23.0 1.3 0.021 15.0 0.1 3.9 3 1 0 3 3 3 1 Immunoglobulin domain Cadherin_C_2 PF16492.5 PIK58425.1 - 0.03 15.1 0.5 0.91 10.3 0.5 2.7 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Stevor PF17410.2 PIK58425.1 - 0.04 13.5 1.1 0.058 12.9 0.1 1.7 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Chordopox_A13L PF05961.11 PIK58425.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein C1-set PF07654.15 PIK58425.1 - 0.12 12.8 0.0 0.52 10.7 0.0 2.1 1 0 0 1 1 1 0 Immunoglobulin C1-set domain YajC PF02699.15 PIK58425.1 - 0.14 12.1 1.2 0.33 10.9 1.2 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit DUF5385 PF17359.2 PIK58425.1 - 0.18 11.3 0.9 0.28 10.7 0.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ATP-synt_B PF00430.18 PIK58425.1 - 0.29 11.2 1.1 0.44 10.7 1.1 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) SKG6 PF08693.10 PIK58425.1 - 1.4 8.4 6.9 3.8 7.0 6.9 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain 7tm_1 PF00001.21 PIK58426.1 - 4.6e-40 137.6 7.9 5.7e-40 137.3 7.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58426.1 - 8.3e-10 38.5 5.5 1.1e-09 38.1 5.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK58426.1 - 1.1e-06 28.4 6.2 2.5e-06 27.3 6.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2909 PF11137.8 PIK58426.1 - 3.9 7.5 8.1 0.28 11.1 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) TUDOR PF00567.24 PIK58427.1 - 4.3e-107 352.9 11.2 2.9e-26 91.9 0.3 6.5 6 0 0 6 6 6 6 Tudor domain zf-B_box PF00643.24 PIK58427.1 - 2.9e-12 46.5 31.4 4.8e-10 39.4 1.5 4.2 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 PIK58427.1 - 6.5e-06 26.0 8.6 6.5e-06 26.0 8.6 3.3 4 0 0 4 4 4 1 zinc-RING finger domain Agenet PF05641.12 PIK58427.1 - 6.9e-05 23.2 3.4 1.9 9.0 0.0 5.1 5 1 0 5 5 5 1 Agenet domain zf-RING_UBOX PF13445.6 PIK58427.1 - 0.00019 21.4 6.3 0.00071 19.6 6.3 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK58427.1 - 0.00041 20.2 8.8 0.00041 20.2 8.8 3.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK58427.1 - 0.00058 20.2 8.0 0.00058 20.2 8.0 4.0 4 0 0 4 4 4 1 Ring finger domain DUF4537 PF15057.6 PIK58427.1 - 0.0011 18.9 0.1 15 5.7 0.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 PIK58427.1 - 0.0022 17.8 3.6 0.36 10.7 0.0 3.3 4 0 0 4 4 4 2 DNA repair protein Crb2 Tudor domain Sh_2 PF17512.2 PIK58427.1 - 0.012 15.3 0.5 0.033 14.0 0.5 1.7 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Peptidase_M50 PF02163.22 PIK58428.1 - 3.4e-14 52.7 0.0 4.6e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M50 Med13_C PF06333.12 PIK58430.1 - 6.2 6.0 11.8 0.39 9.9 4.8 2.1 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain DUF3808 PF10300.9 PIK58431.1 - 0.085 11.6 0.7 0.13 11.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Ashwin PF15323.6 PIK58432.1 - 2e-14 54.2 10.1 2.7e-14 53.8 10.1 1.3 1 0 0 1 1 1 1 Developmental protein RlaP PF10127.9 PIK58433.1 - 0.068 12.8 0.0 0.093 12.3 0.0 1.1 1 0 0 1 1 1 0 RNA repair pathway DNA polymerase beta family STb_secrete PF09075.10 PIK58433.1 - 0.077 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Heat-stable enterotoxin B, secretory polyprenyl_synt PF00348.17 PIK58434.1 - 3.3e-09 36.2 0.0 4.1e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CTD_bind PF04818.13 PIK58435.1 - 9.3e-15 55.2 2.0 1.6e-14 54.5 0.1 2.4 3 0 0 3 3 3 1 RNA polymerase II-binding domain. RRM_occluded PF16842.5 PIK58437.1 - 0.00025 20.8 0.0 0.00037 20.3 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 PIK58437.1 - 0.0025 17.6 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK58437.1 - 0.24 11.0 0.0 0.4 10.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sod_Cu PF00080.20 PIK58438.1 - 6.7e-48 162.5 6.2 7.9e-48 162.2 6.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Kdo PF06293.14 PIK58439.1 - 3.1e-05 23.4 0.2 4.1e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 PIK58439.1 - 0.045 13.1 0.5 0.062 12.6 0.3 1.3 1 1 0 1 1 1 0 Protein kinase domain F5_F8_type_C PF00754.25 PIK58440.1 - 6.1e-37 126.6 0.1 2.5e-14 53.5 0.1 3.4 3 0 0 3 3 3 3 F5/8 type C domain Ldl_recept_a PF00057.18 PIK58440.1 - 8.6e-37 125.1 97.8 2.6e-10 40.3 11.1 8.5 8 0 0 8 8 8 6 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK58440.1 - 1.3e-23 83.4 0.0 2.2e-12 47.3 0.0 3.5 3 0 0 3 3 3 2 CUB domain EGF_CA PF07645.15 PIK58440.1 - 4e-06 26.9 6.1 4e-06 26.9 6.1 8.0 4 2 5 9 9 9 1 Calcium-binding EGF domain 7tm_1 PF00001.21 PIK58440.1 - 1.1e-05 25.0 0.3 2.1e-05 24.0 0.3 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FXa_inhibition PF14670.6 PIK58440.1 - 0.00011 22.4 9.1 0.00011 22.4 9.1 4.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site DUF3421 PF11901.8 PIK58441.1 - 4e-26 91.3 6.9 2.6e-09 37.1 0.3 3.6 2 1 2 4 4 4 3 Protein of unknown function (DUF3421) Aerolysin PF01117.20 PIK58441.1 - 4.9e-06 26.0 0.3 6.5e-06 25.6 0.3 1.1 1 0 0 1 1 1 1 Aerolysin toxin ETX_MTX2 PF03318.13 PIK58441.1 - 0.0029 17.4 3.1 0.0029 17.4 3.1 1.6 1 1 1 2 2 2 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Galactosyl_T PF01762.21 PIK58442.1 - 9.9e-43 146.2 0.1 1.4e-42 145.7 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 PIK58442.1 - 3.7e-06 26.6 0.4 5.9e-06 25.9 0.4 1.4 1 1 0 1 1 1 1 Fringe-like YacG PF03884.14 PIK58443.1 - 0.023 14.4 3.3 17 5.2 0.0 4.5 6 0 0 6 6 6 0 DNA gyrase inhibitor YacG Rieske PF00355.26 PIK58443.1 - 0.043 13.8 2.2 33 4.5 0.3 3.9 1 1 2 3 3 3 0 Rieske [2Fe-2S] domain MFS_1 PF07690.16 PIK58444.1 - 1.3e-10 40.8 21.7 1.3e-10 40.8 21.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily SRCR PF00530.18 PIK58445.1 - 5.6e-32 110.2 1.6 6.9e-32 109.9 1.6 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK58445.1 - 0.00013 22.5 0.1 0.00022 21.7 0.1 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.18 PIK58448.1 - 2.6e-49 165.8 0.3 1.5e-23 83.1 0.0 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK58448.1 - 1.2e-13 51.4 3.6 2e-06 28.3 1.1 2.7 2 2 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK58448.1 - 2.1e-07 31.5 0.3 0.0016 18.9 0.0 3.4 1 1 2 4 4 4 2 Hepsin, SRCR domain YecR PF13992.6 PIK58448.1 - 0.17 12.2 2.5 18 5.7 0.0 3.1 3 0 0 3 3 3 0 YecR-like lipoprotein rve PF00665.26 PIK58449.1 - 2e-22 79.6 0.0 3e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58449.1 - 5.5e-05 22.9 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK58449.1 - 6.4e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS240 PF13610.6 PIK58449.1 - 0.0067 16.6 0.0 0.17 12.1 0.0 2.3 2 0 0 2 2 2 1 DDE domain RT_RNaseH_2 PF17919.1 PIK58450.1 - 8.7e-37 125.2 0.0 1.6e-36 124.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58450.1 - 1.3e-35 121.8 0.0 2.3e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58450.1 - 9.3e-22 77.6 0.0 2e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 PIK58450.1 - 0.078 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain DUF2362 PF10154.9 PIK58450.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) rve PF00665.26 PIK58451.1 - 1e-21 77.4 0.0 1.7e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK58451.1 - 5.9e-16 58.3 0.6 9.5e-16 57.7 0.6 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK58451.1 - 7.7e-05 22.4 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK58451.1 - 0.00066 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS240 PF13610.6 PIK58451.1 - 0.017 15.3 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 DDE domain RVT_1 PF00078.27 PIK58452.1 - 4.6e-22 78.6 0.0 1e-21 77.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK58452.1 - 0.0078 16.5 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK58452.1 - 0.059 13.9 0.0 0.18 12.4 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK58452.1 - 0.18 12.4 0.1 0.53 11.0 0.0 1.8 2 0 0 2 2 2 0 Aspartyl protease rve PF00665.26 PIK58453.1 - 1.2e-24 86.8 0.0 1.4e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58453.1 - 0.00017 21.3 0.0 0.00032 20.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK58454.1 - 1.6e-29 101.9 0.1 3.1e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58454.1 - 1.2e-27 96.2 0.0 2.7e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SMYLE_N PF18615.1 PIK58454.1 - 0.053 13.1 0.1 0.071 12.7 0.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Cnd1_N PF12922.7 PIK58454.1 - 0.17 11.7 1.6 0.29 11.0 1.6 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term RVT_1 PF00078.27 PIK58455.1 - 2.4e-16 59.9 0.0 3.3e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1638 PF07796.11 PIK58455.1 - 0.087 12.9 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) gag-asp_proteas PF13975.6 PIK58456.1 - 0.0011 19.5 0.0 0.0019 18.8 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK58456.1 - 0.0049 17.5 0.0 0.0078 16.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK58456.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.10 PIK58456.1 - 0.2 11.4 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease Pox_MCEL PF03291.16 PIK58458.1 - 0.0095 15.1 4.7 0.012 14.8 4.7 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Retrotran_gag_2 PF14223.6 PIK58458.1 - 0.016 14.8 4.3 0.029 14.0 4.3 1.4 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type Asp1 PF16993.5 PIK58458.1 - 0.019 14.2 1.0 0.022 14.0 1.0 1.1 1 0 0 1 1 1 0 Accessory Sec system protein Asp1 DUF2524 PF10732.9 PIK58458.1 - 0.54 10.6 4.6 1.1 9.6 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2524) RVT_1 PF00078.27 PIK58459.1 - 8.2e-38 130.1 0.1 1.1e-37 129.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 PIK58460.1 - 2.5e-23 82.7 8.9 3e-23 82.5 8.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Suf PF05843.14 PIK58461.1 - 1.2e-73 248.6 14.1 1.1e-72 245.5 0.2 4.9 3 2 0 4 4 4 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 PIK58461.1 - 0.033 13.3 10.3 1.7 7.7 0.0 4.6 4 1 0 4 4 4 0 NRDE-2, necessary for RNA interference SF3A3 PF16837.5 PIK58461.1 - 1.6 9.3 4.3 70 4.0 0.1 3.6 3 1 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 NACHT PF05729.12 PIK58462.1 - 5.3e-14 52.5 0.0 8.4e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK58462.1 - 0.0012 18.5 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain DED PF01335.21 PIK58462.1 - 0.0056 17.0 0.4 0.016 15.5 0.1 1.9 2 0 0 2 2 2 1 Death effector domain ATPase PF06745.13 PIK58462.1 - 0.008 15.6 0.1 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 KaiC ResIII PF04851.15 PIK58462.1 - 0.0092 16.0 0.2 0.021 14.8 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DnaB_C PF03796.15 PIK58462.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_24 PF13479.6 PIK58462.1 - 0.031 14.0 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 PIK58462.1 - 0.043 13.0 0.0 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain IstB_IS21 PF01695.17 PIK58462.1 - 0.045 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 PIK58462.1 - 0.053 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 PIK58462.1 - 0.058 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 PIK58462.1 - 0.076 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 PIK58462.1 - 0.098 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 PIK58462.1 - 0.14 12.6 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 PIK58462.1 - 0.14 12.6 0.0 0.97 10.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter EF-hand_6 PF13405.6 PIK58463.1 - 1.2e-07 31.0 0.0 0.007 16.2 0.0 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 PIK58463.1 - 2.9e-07 30.8 5.7 4.3e-06 27.1 2.3 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK58463.1 - 3.2e-06 26.4 0.2 7.4e-05 22.1 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 PIK58463.1 - 0.00022 20.6 3.7 0.0015 17.9 0.0 3.9 4 1 0 4 4 4 1 EF hand T6SS_TssG PF06996.11 PIK58463.1 - 0.0038 16.5 0.0 0.0093 15.2 0.0 1.6 1 0 0 1 1 1 1 Type VI secretion, TssG EF-hand_8 PF13833.6 PIK58463.1 - 0.024 14.5 0.1 1.1 9.2 0.0 2.9 1 1 1 2 2 2 0 EF-hand domain pair DUF1126 PF06565.12 PIK58463.1 - 0.063 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 DUF1126 PH-like domain UPF0489 PF12640.7 PIK58463.1 - 0.077 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain Arylesterase PF01731.20 PIK58464.1 - 9.2e-12 45.0 0.0 2.1e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 PIK58464.1 - 0.00066 19.3 0.0 0.0019 17.8 0.0 1.7 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 PIK58464.1 - 0.0034 16.7 0.0 0.0069 15.7 0.0 1.5 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller Str_synth PF03088.16 PIK58464.1 - 0.076 13.1 0.0 0.49 10.6 0.0 2.4 2 0 0 2 2 2 0 Strictosidine synthase 7tm_1 PF00001.21 PIK58465.1 - 2.5e-31 109.0 16.0 3.2e-31 108.6 16.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK58465.1 - 4.4e-09 36.1 13.1 5.1e-09 35.9 13.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 PIK58465.1 - 4e-07 29.9 11.8 4.2e-06 26.6 11.8 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 PIK58465.1 - 1.4e-05 24.6 14.4 0.00012 21.5 14.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 PIK58465.1 - 0.00016 21.5 11.8 0.00021 21.1 11.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK58465.1 - 0.0039 16.6 15.4 0.0056 16.1 15.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1129 PF06570.11 PIK58465.1 - 1.1 8.7 10.4 0.068 12.6 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) zf-H2C2_2 PF13465.6 PIK58466.1 - 3.9e-14 52.3 13.4 8e-06 26.1 0.5 3.7 3 0 0 3 3 3 3 Zinc-finger double domain NPL PF17800.1 PIK58466.1 - 2.7e-11 44.0 0.0 2.7e-11 44.0 0.0 2.4 2 1 0 2 2 2 1 Nucleoplasmin-like domain zf-C2H2 PF00096.26 PIK58466.1 - 1.6e-08 34.5 21.2 0.0048 17.3 0.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58466.1 - 2.2e-05 24.9 19.1 0.23 12.4 0.3 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 PIK58466.1 - 0.67 10.3 13.6 1.2 9.5 4.8 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK58466.1 - 1 9.7 8.1 8.7 6.8 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK58466.1 - 2.1 8.7 10.1 7.5 7.0 0.8 2.9 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK58466.1 - 4.6 7.1 10.5 0.75 9.6 1.9 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type FYVE PF01363.21 PIK58466.1 - 7.1 6.9 18.7 2.6 8.2 1.9 3.3 1 1 1 3 3 3 0 FYVE zinc finger zf-RING_5 PF14634.6 PIK58466.1 - 7.9 6.5 9.1 25 5.0 0.1 2.9 2 1 0 2 2 2 0 zinc-RING finger domain AIG1 PF04548.16 PIK58467.1 - 1.1e-38 132.7 2.4 2.3e-38 131.7 2.4 1.5 1 0 0 1 1 1 1 AIG1 family Hint PF01079.20 PIK58467.1 - 1.5e-34 119.4 0.0 2.9e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Hint module CARD PF00619.21 PIK58467.1 - 1.8e-09 37.5 0.0 5e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Caspase recruitment domain MMR_HSR1 PF01926.23 PIK58467.1 - 1.3e-08 34.9 0.8 2.7e-08 33.9 0.8 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK58467.1 - 8.2e-06 25.4 0.1 1.9e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 PIK58467.1 - 4.1e-05 23.0 0.4 7.7e-05 22.1 0.4 1.3 1 0 0 1 1 1 1 Septin Intein_splicing PF14890.6 PIK58467.1 - 0.0039 17.1 0.1 0.012 15.6 0.0 1.9 2 0 0 2 2 2 1 Intein splicing domain RsgA_GTPase PF03193.16 PIK58467.1 - 0.021 14.8 0.1 0.056 13.3 0.1 1.8 1 0 0 1 1 1 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 PIK58467.1 - 0.029 13.7 0.1 0.067 12.5 0.1 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.12 PIK58467.1 - 0.032 13.6 0.2 0.083 12.2 0.2 1.7 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region T2SSE PF00437.20 PIK58467.1 - 0.058 12.5 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Interferon PF00143.19 PIK58467.1 - 0.1 12.8 1.2 0.25 11.5 1.2 1.6 1 0 0 1 1 1 0 Interferon alpha/beta domain AAA_7 PF12775.7 PIK58467.1 - 0.11 12.0 0.2 0.32 10.5 0.2 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 PIK58467.1 - 0.15 12.6 1.5 0.28 11.7 0.1 2.2 3 0 0 3 3 3 0 ABC transporter AAA_29 PF13555.6 PIK58467.1 - 0.2 11.5 0.3 0.48 10.2 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 PIK58467.1 - 3.1 7.8 11.5 0.91 9.6 0.2 3.3 3 1 1 4 4 3 0 Dynamin family Ras PF00071.22 PIK58468.1 - 5.2e-29 100.9 0.1 6.8e-29 100.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK58468.1 - 1e-21 77.4 0.0 1.4e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK58468.1 - 2.1e-06 27.3 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK58468.1 - 0.00017 21.2 0.0 0.0016 18.0 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK58468.1 - 0.042 13.2 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 PIK58468.1 - 0.067 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF1801 PF08818.11 PIK58468.1 - 0.19 12.2 0.5 8.1 7.0 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DU1801) LRR_8 PF13855.6 PIK58469.1 - 3.8e-25 87.4 25.4 3e-11 42.9 0.6 4.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 PIK58469.1 - 1.8e-14 53.8 3.7 2.6e-06 27.4 0.0 2.6 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK58469.1 - 5.8e-10 39.3 26.6 0.00024 21.4 0.5 5.7 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK58469.1 - 0.00059 20.0 24.3 0.9 10.3 0.0 8.4 8 2 0 8 8 8 2 Leucine Rich Repeat Neurensin PF14927.6 PIK58469.1 - 0.0017 18.0 0.7 0.23 11.1 0.0 3.3 3 0 0 3 3 3 1 Neurensin LRR_9 PF14580.6 PIK58469.1 - 0.0034 16.9 4.3 1.2 8.6 0.2 3.1 2 1 1 3 3 3 2 Leucine-rich repeat zf-H2C2_2 PF13465.6 PIK58471.1 - 4.2e-17 61.7 41.3 7.3e-08 32.5 0.1 5.8 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58471.1 - 2.1e-16 59.4 32.0 2.7e-05 24.4 1.4 4.6 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58471.1 - 2.1e-10 40.5 25.1 0.0078 17.0 1.2 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger C1_4 PF07975.12 PIK58471.1 - 2.7e-07 30.7 4.5 0.0059 16.8 3.7 2.9 2 1 1 3 3 3 2 TFIIH C1-like domain DUF3268 PF11672.8 PIK58471.1 - 3.5e-07 30.5 3.6 0.01 16.1 0.1 2.4 2 0 0 2 2 2 2 zinc-finger-containing domain zf-C2H2_6 PF13912.6 PIK58471.1 - 2.9e-06 27.1 23.8 0.0038 17.2 2.2 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK58471.1 - 1.4e-05 25.3 12.2 0.013 15.7 2.2 2.6 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 PIK58471.1 - 0.00023 21.2 11.5 0.063 13.4 1.2 3.4 3 0 0 3 3 3 2 Zinc ribbon domain zf-C2HC_2 PF13913.6 PIK58471.1 - 0.00074 19.3 13.6 0.23 11.4 0.1 4.2 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-Sec23_Sec24 PF04810.15 PIK58471.1 - 0.0012 18.8 9.7 4 7.6 0.3 4.2 3 1 1 4 4 4 1 Sec23/Sec24 zinc finger zf-AN1 PF01428.16 PIK58471.1 - 0.0015 18.6 12.5 2.9 8.1 0.2 4.3 4 0 0 4 4 4 1 AN1-like Zinc finger FYVE PF01363.21 PIK58471.1 - 0.0049 17.0 3.8 0.0049 17.0 3.8 2.6 1 1 1 2 2 2 1 FYVE zinc finger HypA PF01155.19 PIK58471.1 - 0.01 15.9 6.6 0.17 11.9 0.3 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PHF5 PF03660.14 PIK58471.1 - 0.016 15.4 3.3 0.097 12.9 0.5 2.2 1 1 1 2 2 2 0 PHF5-like protein zf-met PF12874.7 PIK58471.1 - 0.017 15.5 19.3 0.45 11.0 1.7 4.6 4 1 0 4 4 4 0 Zinc-finger of C2H2 type Elf1 PF05129.13 PIK58471.1 - 0.021 14.9 12.0 0.037 14.1 3.0 3.1 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like FYDLN_acid PF09538.10 PIK58471.1 - 0.021 15.5 7.0 0.83 10.4 0.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) CpXC PF14353.6 PIK58471.1 - 0.029 14.4 11.0 4.2 7.4 0.1 4.2 1 1 3 4 4 4 0 CpXC protein zf-C2H2_3rep PF18868.1 PIK58471.1 - 0.029 15.0 12.4 0.13 12.9 0.3 4.1 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_15 PF17032.5 PIK58471.1 - 0.041 14.6 6.3 1.5 9.7 1.6 2.5 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 PIK58471.1 - 0.044 14.1 17.0 3.4 8.1 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK58471.1 - 0.051 13.5 12.1 4.1 7.4 0.1 3.7 2 1 2 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Gmx_para_CXXCG PF09535.10 PIK58471.1 - 0.069 12.4 1.8 1.7 7.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) zf_UBZ PF18439.1 PIK58471.1 - 0.099 12.3 9.6 1.6 8.4 0.1 3.6 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Zn_Tnp_IS1595 PF12760.7 PIK58471.1 - 0.12 12.4 17.5 0.84 9.7 0.3 3.6 3 1 0 3 3 3 0 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.10 PIK58471.1 - 0.12 12.1 8.2 0.55 9.9 1.6 2.4 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zinc-ribbons_6 PF07191.12 PIK58471.1 - 0.16 12.0 10.2 5.5 7.1 3.0 3.6 1 1 1 2 2 2 0 zinc-ribbons DZR PF12773.7 PIK58471.1 - 0.29 11.2 9.2 19 5.3 9.2 2.7 1 1 0 1 1 1 0 Double zinc ribbon Fer2_2 PF01799.20 PIK58471.1 - 0.43 10.6 3.8 1.7 8.7 0.6 2.4 1 1 1 2 2 2 0 [2Fe-2S] binding domain zf-C2H2_2 PF12756.7 PIK58471.1 - 0.46 10.8 13.5 36 4.8 8.9 3.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.6 PIK58471.1 - 0.54 10.1 12.8 4.4 7.1 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain HNH PF01844.23 PIK58471.1 - 0.59 10.3 12.0 0.84 9.9 0.1 4.0 4 0 0 4 4 4 0 HNH endonuclease Prok-RING_1 PF14446.6 PIK58471.1 - 0.95 9.4 11.1 8 6.5 0.1 4.1 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 FdhE PF04216.12 PIK58471.1 - 1 9.2 6.2 5.9 6.7 0.3 2.8 1 1 2 3 3 3 0 Protein involved in formate dehydrogenase formation DpnI PF06044.12 PIK58471.1 - 1.8 8.2 8.0 0.17 11.5 0.6 2.6 1 1 2 3 3 3 0 Dam-replacing family Zn_ribbon_SprT PF17283.2 PIK58471.1 - 2.7 8.0 13.4 2.9 7.9 1.4 3.3 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zf-nanos PF05741.13 PIK58471.1 - 4.1 7.7 15.4 31 4.9 4.5 3.8 2 2 0 2 2 2 0 Nanos RNA binding domain zf-C2HE PF16278.5 PIK58471.1 - 5.9 7.4 19.7 1.2 9.6 0.6 4.1 1 1 3 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-C2H2_12 PF18112.1 PIK58471.1 - 6.6 7.3 8.4 6.9 7.2 0.3 4.0 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain TF_Zn_Ribbon PF08271.12 PIK58471.1 - 8.1 6.0 9.2 6.9 6.3 0.3 3.4 2 2 1 3 3 3 0 TFIIB zinc-binding Desulfoferrod_N PF06397.12 PIK58471.1 - 8.6 6.1 7.6 2.9 7.6 0.6 2.9 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-H2C2_2 PF13465.6 PIK58472.1 - 2e-06 28.0 27.5 2.3e-05 24.6 3.6 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK58472.1 - 3.5e-06 27.4 25.0 0.023 15.5 0.3 4.6 3 1 1 4 4 4 4 C2H2-type zinc finger zf-CHCC PF10276.9 PIK58472.1 - 0.004 17.2 8.7 3.2 7.9 0.2 3.7 3 1 1 4 4 4 2 Zinc-finger domain PyrI_C PF02748.15 PIK58472.1 - 0.0041 17.0 16.9 0.46 10.4 0.6 4.1 1 1 3 4 4 4 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain HypA PF01155.19 PIK58472.1 - 0.019 15.0 9.4 0.14 12.2 4.9 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE PF01363.21 PIK58472.1 - 0.074 13.2 21.4 0.95 9.7 15.5 3.1 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2 PF00096.26 PIK58472.1 - 0.12 12.9 30.7 1.1 9.8 2.0 4.4 3 1 1 4 4 4 0 Zinc finger, C2H2 type YyzF PF14116.6 PIK58472.1 - 0.62 10.1 13.7 14 5.8 0.9 4.1 3 1 1 4 4 4 0 YyzF-like protein zf-C2H2_jaz PF12171.8 PIK58472.1 - 1.7 9.0 15.7 0.25 11.7 1.0 4.3 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK58472.1 - 1.9 8.7 22.0 2 8.7 0.2 4.3 3 1 0 4 4 4 0 AN1-like Zinc finger Zf_RING PF16744.5 PIK58472.1 - 2.4 8.4 15.6 15 5.8 5.3 4.1 1 1 2 3 3 3 0 KIAA1045 RING finger zf-BED PF02892.15 PIK58472.1 - 2.5 8.2 19.4 18 5.4 0.3 4.2 1 1 3 4 4 4 0 BED zinc finger zf-C2HC5 PF06221.13 PIK58472.1 - 4.6 7.3 11.3 7.2 6.7 0.3 3.8 1 1 3 4 4 4 0 Putative zinc finger motif, C2HC5-type zinc-ribbons_6 PF07191.12 PIK58472.1 - 6.2 6.9 12.8 5.8 7.0 3.8 3.1 1 1 1 2 2 2 0 zinc-ribbons HNH_5 PF14279.6 PIK58472.1 - 8.6 6.3 15.7 22 5.0 0.4 4.0 4 0 0 4 4 4 0 HNH endonuclease GCV_T PF01571.21 PIK58473.1 - 3.7e-08 33.0 0.0 5.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DUF4207 PF13904.6 PIK58474.1 - 1.9e-20 73.7 65.7 1.9e-20 73.7 65.7 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4207) Asp-B-Hydro_N PF05279.11 PIK58474.1 - 0.057 13.5 30.6 0.11 12.5 30.6 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Hamartin PF04388.12 PIK58474.1 - 2.5 6.6 34.3 3.5 6.2 34.3 1.2 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 PIK58474.1 - 6.1 5.3 40.3 9.3 4.7 40.3 1.2 1 0 0 1 1 1 0 Macoilin family RVT_1 PF00078.27 PIK58475.1 - 2.9e-13 49.8 0.0 4.6e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK58476.1 - 3.2e-36 123.8 0.0 4.2e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58476.1 - 5.9e-35 119.3 0.0 9e-35 118.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DnaJ PF00226.31 PIK58477.1 - 6.2e-29 99.9 1.8 8.2e-29 99.5 1.8 1.2 1 0 0 1 1 1 1 DnaJ domain CAP PF00188.26 PIK58478.1 - 3e-20 73.3 1.5 3e-20 73.3 1.5 1.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family ALS2CR8 PF15299.6 PIK58479.1 - 7.9e-48 163.2 0.1 1.2e-47 162.6 0.1 1.3 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 ORMDL PF04061.14 PIK58480.1 - 3.8e-29 101.2 3.5 4.7e-29 100.9 3.5 1.0 1 0 0 1 1 1 1 ORMDL family Put_Phosphatase PF06888.12 PIK58481.1 - 3.1e-18 66.0 0.0 3.2e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase Put_Phosphatase PF06888.12 PIK58483.1 - 5.6e-18 65.2 0.0 5.9e-18 65.1 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase AGO_N PF18236.1 PIK58484.1 - 0.069 13.4 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Argonaute N domain Integrin_alpha2 PF08441.12 PIK58486.1 - 4.7e-18 65.3 2.5 5.2e-16 58.6 2.5 2.6 1 1 0 1 1 1 1 Integrin alpha Integrin_alpha2 PF08441.12 PIK58487.1 - 2.7e-30 105.7 0.3 5.2e-19 68.5 0.2 2.2 2 0 0 2 2 2 2 Integrin alpha FG-GAP PF01839.23 PIK58487.1 - 1.6e-15 56.9 21.0 2.4e-09 37.2 1.1 5.3 6 0 0 6 6 6 3 FG-GAP repeat VCBS PF13517.6 PIK58487.1 - 5e-08 33.4 5.9 9.1e-07 29.4 0.4 3.5 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 PIK58487.1 - 1.4e-07 31.7 5.0 0.029 14.6 0.2 4.0 3 0 0 3 3 3 2 FG-GAP repeat HisK_sensor PF18698.1 PIK58487.1 - 0.00054 20.3 0.7 0.39 11.1 0.0 2.7 3 0 0 3 3 3 2 Histidine kinase sensor domain RNA_pol_Rpb2_2 PF04561.14 PIK58488.1 - 1e-07 31.8 0.0 1.6e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Rubredoxin PF00301.20 PIK58489.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Rubredoxin Gly_radical PF01228.21 PIK58489.1 - 0.12 12.9 0.0 0.43 11.1 0.0 1.9 1 0 0 1 1 1 0 Glycine radical RNA_pol_Rpb2_6 PF00562.28 PIK58492.1 - 8.5e-79 265.4 0.0 4.8e-75 253.0 0.0 2.1 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 PIK58492.1 - 1.1e-34 118.6 0.8 2.4e-34 117.6 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_7 PF04560.20 PIK58493.1 - 5.1e-33 113.3 0.2 1.1e-19 70.6 0.5 2.3 1 1 1 2 2 2 2 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_6 PF00562.28 PIK58493.1 - 3.4e-26 92.2 0.1 4.6e-26 91.8 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 zf-TFIIB PF13453.6 PIK58493.1 - 0.055 12.8 4.3 3.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger RNA_pol_Rpb2_1 PF04563.15 PIK58494.1 - 1.9e-38 132.1 0.0 9.7e-38 129.7 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 PIK58494.1 - 6.2e-28 97.7 0.6 1.1e-27 96.9 0.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 PIK58494.1 - 2.7e-23 82.0 0.2 2.7e-23 82.0 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 PIK58494.1 - 2.2e-21 75.8 0.2 6e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_6 PF00562.28 PIK58494.1 - 1e-09 38.0 0.0 1.9e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 Ank_2 PF12796.7 PIK58495.1 - 1.7e-36 124.6 0.2 7.2e-13 48.9 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK58495.1 - 8.3e-34 115.2 1.7 8e-09 35.6 0.0 6.1 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK58495.1 - 1.1e-32 108.4 0.9 8.4e-06 25.8 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 PIK58495.1 - 3.7e-32 109.3 6.6 9e-06 25.9 0.2 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 PIK58495.1 - 1.4e-30 105.3 2.0 3.3e-07 30.7 0.1 5.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) SH3_2 PF07653.17 PIK58495.1 - 8.4e-09 35.0 0.0 2.4e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK58495.1 - 1.7e-05 24.3 0.0 2.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK58495.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2384 PF09722.10 PIK58495.1 - 0.079 13.0 0.0 8.1 6.6 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2384) Pribosyl_synth PF14572.6 PIK58496.1 - 1.4e-89 299.0 0.0 2.3e-89 298.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 PIK58496.1 - 1.1e-37 128.5 0.2 2.9e-37 127.1 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 PIK58496.1 - 8.8e-08 31.8 0.1 3.6e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain RelB PF04221.12 PIK58496.1 - 0.015 15.2 0.0 2.6 8.1 0.0 2.6 2 0 0 2 2 2 0 RelB antitoxin S_layer_C PF05124.12 PIK58496.1 - 0.022 14.8 0.1 0.037 14.0 0.1 1.4 1 0 0 1 1 1 0 S-layer like family, C-terminal region Thioredoxin_16 PF18569.1 PIK58497.1 - 9.5e-30 102.6 0.4 1.6e-29 101.8 0.4 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain GST_C_6 PF17171.4 PIK58497.1 - 0.00014 21.5 0.0 0.00035 20.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK58497.1 - 0.00064 19.9 0.1 0.011 16.0 0.0 2.4 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK58497.1 - 0.0017 18.4 0.1 0.0054 16.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain AIMP2_LysRS_bd PF16780.5 PIK58497.1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 0 AIMP2 lysyl-tRNA synthetase binding domain TMCCDC2 PF15844.5 PIK58497.1 - 0.16 11.9 0.0 0.48 10.3 0.0 1.7 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 DDT PF02791.17 PIK58498.1 - 3.3e-12 46.5 0.7 3.3e-12 46.5 0.7 2.4 3 0 0 3 3 3 1 DDT domain WHIM1 PF15612.6 PIK58498.1 - 1.1e-08 34.4 0.0 2.6e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD PF00628.29 PIK58498.1 - 8.4e-08 32.0 12.9 1.9e-07 30.9 12.2 2.0 2 0 0 2 2 2 1 PHD-finger WSD PF15613.6 PIK58498.1 - 5.2e-07 30.1 1.1 5.2e-07 30.1 1.1 5.4 3 3 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif ADK_lid PF05191.14 PIK58498.1 - 0.55 10.3 3.4 1.6 8.8 3.4 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid Prok-RING_1 PF14446.6 PIK58498.1 - 1.2 9.2 8.9 1.8 8.5 7.3 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Bromodomain PF00439.25 PIK58499.1 - 2.6e-21 75.5 0.1 7.8e-21 74.0 0.1 1.9 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 PIK58499.1 - 6.5e-19 67.6 22.0 1.1e-10 41.3 6.5 2.6 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 PIK58499.1 - 0.0079 15.7 13.1 0.043 13.4 3.2 2.6 2 0 0 2 2 2 2 PHD-finger PHD_4 PF16866.5 PIK58499.1 - 1.5 9.0 12.7 11 6.3 7.8 3.1 1 1 1 2 2 2 0 PHD-finger zinc_ribbon_10 PF10058.9 PIK58499.1 - 3.3 7.5 9.3 4.9 6.9 3.4 2.6 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein PIG-X PF08320.12 PIK58500.1 - 4.7e-17 62.6 0.0 5.7e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 PIG-X / PBN1 Thioredox_DsbH PF03190.15 PIK58501.1 - 1.3e-75 252.8 0.0 2.2e-75 252.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 PIK58501.1 - 1.7e-10 41.0 0.0 3.4e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C5-epim_C PF06662.13 PIK58501.1 - 0.0022 17.5 0.8 0.0057 16.2 0.1 2.0 2 1 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 PIK58501.1 - 0.019 13.5 0.9 0.1 11.1 0.2 2.0 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 PIK58501.1 - 0.02 14.4 1.3 3.2 7.2 0.3 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase family 76 LANC_like PF05147.13 PIK58501.1 - 0.033 12.8 0.0 15 4.0 0.0 3.2 3 0 0 3 3 3 0 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.13 PIK58501.1 - 0.034 13.2 0.6 0.23 10.5 0.0 2.4 2 2 0 2 2 2 0 Glycosyl Hydrolase Family 88 Thioredoxin_2 PF13098.6 PIK58501.1 - 0.052 14.0 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Glyco_hydro_47 PF01532.20 PIK58501.1 - 0.13 11.1 0.8 0.65 8.8 0.2 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 47 Glyco_hydro_31 PF01055.26 PIK58502.1 - 8.9e-160 532.7 0.7 1.1e-159 532.3 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK58502.1 - 1.6e-13 50.9 1.0 2.8e-13 50.1 1.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 PIK58502.1 - 8.1e-11 42.1 1.8 7.3e-10 39.0 1.1 2.6 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 PIK58502.1 - 0.00028 21.1 0.0 0.00083 19.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) GHL15 PF14885.6 PIK58502.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Phage_tail_S PF05069.13 PIK58504.1 - 0.085 12.7 1.5 0.22 11.4 1.5 1.8 1 1 0 1 1 1 0 Phage virion morphogenesis family DUF501 PF04417.12 PIK58504.1 - 0.94 9.3 4.8 1.5 8.6 2.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF501) DUF573 PF04504.14 PIK58504.1 - 1.7 9.4 14.5 0.53 11.0 4.3 3.5 3 0 0 3 3 3 0 Protein of unknown function, DUF573 Cadherin_C_2 PF16492.5 PIK58505.1 - 0.0079 16.9 0.5 0.036 14.8 0.5 2.0 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal PQQ PF01011.21 PIK58507.1 - 0.00039 20.2 0.1 0.00094 19.0 0.1 1.7 1 0 0 1 1 1 1 PQQ enzyme repeat Ribonuc_2-5A PF06479.12 PIK58508.1 - 3.5e-45 153.3 0.2 5.8e-45 152.6 0.2 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 PIK58508.1 - 3.1e-43 148.0 0.0 5.8e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58508.1 - 1.1e-25 90.4 0.0 2e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK58508.1 - 8.9e-08 31.3 0.0 1.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK58508.1 - 0.00082 18.8 0.1 0.002 17.6 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK58508.1 - 0.0032 17.4 0.3 0.024 14.6 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RRM_1 PF00076.22 PIK58509.1 - 0.02 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_C PF00433.24 PIK58512.1 - 2.6e-05 24.8 0.1 5e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain TIL PF01826.17 PIK58514.1 - 1.4e-07 31.6 15.1 1.4e-07 31.6 15.1 4.1 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK58514.1 - 4.9e-07 29.6 12.8 4.9e-07 29.6 12.8 4.0 2 1 2 4 4 4 1 TILa domain Fibrinogen_C PF00147.18 PIK58514.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK58514.1 - 0.0018 18.5 12.3 0.0018 18.5 12.3 4.5 4 1 0 4 4 4 1 EGF domain Fibrinogen_C PF00147.18 PIK58515.1 - 3e-36 125.3 0.9 5.6e-36 124.4 0.9 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58515.1 - 3.3e-10 39.8 13.8 3.3e-10 39.8 13.8 3.6 2 1 1 3 3 3 1 TILa domain TIL PF01826.17 PIK58515.1 - 5.3e-06 26.6 8.7 5.3e-06 26.6 8.7 3.4 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58515.1 - 0.0026 17.9 11.8 0.0026 17.9 11.8 4.0 2 2 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK58515.1 - 0.0039 17.2 28.8 0.022 14.8 10.6 3.6 3 0 0 3 3 3 2 MSP1 EGF domain 1 RVT_1 PF00078.27 PIK58516.1 - 2.1e-22 79.8 0.1 4.7e-22 78.6 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Laminin_G_2 PF02210.24 PIK58517.1 - 8.8e-47 158.8 0.0 3.8e-14 53.3 0.0 3.4 3 1 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 PIK58517.1 - 4.2e-44 149.9 0.0 2.3e-16 60.2 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.6 PIK58517.1 - 2.6e-11 43.9 0.0 5.9e-05 23.3 0.1 3.1 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily TIL PF01826.17 PIK58518.1 - 1e-07 32.1 15.9 1e-07 32.1 15.9 2.4 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK58519.1 - 3.4e-09 36.8 0.9 2.3e-05 24.3 0.1 2.3 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58519.1 - 4.7e-07 30.0 15.5 4.7e-07 30.0 15.5 4.0 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK58519.1 - 1.6e-05 24.8 12.7 1.6e-05 24.8 12.7 3.6 2 1 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK58519.1 - 0.00077 19.6 12.6 0.00077 19.6 12.6 4.1 3 1 0 3 3 3 1 EGF domain Fibrinogen_C PF00147.18 PIK58520.1 - 4e-53 180.5 19.8 1.1e-29 103.9 13.0 2.7 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58520.1 - 1.1e-05 25.6 10.3 1.1e-05 25.6 10.3 2.6 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain GIY-YIG PF01541.24 PIK58521.1 - 2.2e-05 24.6 0.3 4.3e-05 23.7 0.3 1.6 1 1 0 1 1 1 1 GIY-YIG catalytic domain TIL PF01826.17 PIK58522.1 - 1.1e-07 32.0 15.9 1.1e-07 32.0 15.9 4.3 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK58522.1 - 7.4e-07 29.0 14.6 7.4e-07 29.0 14.6 4.2 2 1 2 4 4 4 1 TILa domain Fibrinogen_C PF00147.18 PIK58522.1 - 3.9e-06 26.8 0.1 6.6e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK58522.1 - 0.0022 18.2 12.5 0.0022 18.2 12.5 4.5 4 1 0 4 4 4 1 EGF domain Fibrinogen_C PF00147.18 PIK58523.1 - 4e-79 265.5 24.7 9.2e-41 140.1 14.7 2.8 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58523.1 - 5e-09 36.0 14.7 5e-09 36.0 14.7 4.6 4 2 1 5 5 5 1 TILa domain TIL PF01826.17 PIK58523.1 - 2.6e-05 24.4 9.7 2.6e-05 24.4 9.7 4.6 4 1 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58523.1 - 0.0014 18.8 10.8 0.0014 18.8 10.8 4.9 3 2 1 4 4 4 1 EGF domain Flo11 PF10182.9 PIK58523.1 - 0.0018 18.4 1.1 0.28 11.3 0.1 2.6 2 0 0 2 2 2 2 Flo11 domain EGF_MSP1_1 PF12946.7 PIK58523.1 - 0.026 14.6 1.9 0.026 14.6 1.9 3.7 3 0 0 3 3 3 0 MSP1 EGF domain 1 TIL PF01826.17 PIK58524.1 - 1.7e-07 31.4 15.4 1.7e-07 31.4 15.4 2.4 3 0 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK58525.1 - 1.7e-63 214.4 7.8 7.7e-40 137.0 1.6 2.0 1 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58525.1 - 9.4e-06 25.8 10.3 9.4e-06 25.8 10.3 1.7 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK58525.1 - 0.05 13.7 1.7 0.14 12.2 1.7 1.8 1 0 0 1 1 1 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK58526.1 - 2.4e-36 125.6 5.5 2.7e-36 125.5 1.8 2.1 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58526.1 - 7.9e-10 38.6 14.5 7.9e-10 38.6 14.5 3.6 2 1 1 3 3 3 1 TILa domain TIL PF01826.17 PIK58526.1 - 1.5e-05 25.1 10.1 1.5e-05 25.1 10.1 3.4 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK58526.1 - 0.00095 19.3 11.1 0.00095 19.3 11.1 4.2 2 2 1 3 3 3 1 EGF domain Tme5_EGF_like PF09064.10 PIK58526.1 - 4.1 7.4 27.8 1.9 8.4 8.0 3.6 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like EGF_MSP1_1 PF12946.7 PIK58526.1 - 9.3 6.4 34.1 0.19 11.8 10.6 3.9 4 0 0 4 4 4 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK58527.1 - 2.5e-38 132.1 15.4 1.8e-37 129.3 15.4 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58527.1 - 2.3e-06 27.8 8.6 2.3e-06 27.8 8.6 2.8 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Thymidylate_kin PF02223.17 PIK58527.1 - 0.0011 18.7 6.0 0.83 9.3 0.1 3.7 1 1 3 4 4 4 3 Thymidylate kinase Mucin-like PF16058.5 PIK58527.1 - 3.5 7.8 6.8 2.6 8.2 4.2 1.9 1 1 1 2 2 2 0 Mucin-like Atthog PF18800.1 PIK58528.1 - 1.1e-35 122.6 1.1 1.5e-35 122.2 1.1 1.1 1 0 0 1 1 1 1 Attenuator of Hedgehog DUF998 PF06197.13 PIK58528.1 - 0.0068 16.0 7.4 0.0068 16.0 7.4 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF998) Claudin_3 PF06653.11 PIK58528.1 - 0.014 15.3 2.6 0.014 15.3 2.6 2.2 2 1 0 2 2 2 0 Tight junction protein, Claudin-like Peptidase_U4 PF03419.13 PIK58528.1 - 0.55 9.5 0.0 0.55 9.5 0.0 2.1 1 1 1 2 2 2 0 Sporulation factor SpoIIGA Transferrin PF00405.17 PIK58529.1 - 2.9e-97 325.8 0.2 2e-92 309.9 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 PIK58529.1 - 6e-07 29.3 0.0 1.2e-06 28.3 0.0 1.4 2 0 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF1126 PF06565.12 PIK58530.1 - 5.3e-106 347.6 1.0 1.6e-33 114.7 0.1 4.2 3 1 0 3 3 3 3 DUF1126 PH-like domain EF-hand_7 PF13499.6 PIK58530.1 - 1.4e-10 41.5 0.5 1.2e-05 25.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK58530.1 - 4.8e-06 25.7 0.3 0.1 12.2 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK58530.1 - 0.00012 21.8 0.8 0.77 9.9 0.1 4.0 3 0 0 3 3 3 2 EF-hand domain DUF5580 PF17743.1 PIK58530.1 - 0.00021 20.0 0.0 0.00032 19.4 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Death PF00531.22 PIK58531.1 - 9.5e-22 77.0 0.1 6.8e-10 39.0 0.0 2.4 2 0 0 2 2 2 2 Death domain Mt_ATP-synt_B PF05405.14 PIK58531.1 - 0.0061 16.2 0.7 0.015 15.0 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) PHY PF00360.20 PIK58531.1 - 0.038 13.3 0.0 0.066 12.5 0.0 1.4 1 0 0 1 1 1 0 Phytochrome region Pkinase_Tyr PF07714.17 PIK58531.1 - 0.092 12.0 0.4 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase Adap_comp_sub PF00928.21 PIK58532.1 - 3.3e-41 141.4 0.2 5.3e-41 140.7 0.2 1.3 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK58532.1 - 0.019 14.9 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Na_Ca_ex PF01699.24 PIK58533.1 - 1.4e-22 80.2 11.4 1.6e-22 80.1 11.4 1.0 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Herpes_LMP1 PF05297.11 PIK58533.1 - 0.27 10.4 3.7 0.33 10.1 3.7 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Ser_hydrolase PF06821.13 PIK58534.1 - 1.8e-10 41.0 0.0 2.2e-10 40.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_6 PF12697.7 PIK58534.1 - 3.8e-05 24.4 0.0 5.3e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK58534.1 - 6.8e-05 22.2 0.0 7.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 PIK58534.1 - 0.00059 19.0 0.0 0.002 17.2 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_5 PF12695.7 PIK58534.1 - 0.011 15.5 0.0 0.054 13.3 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF1749 PF08538.10 PIK58534.1 - 0.015 14.4 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Abhydrolase_1 PF00561.20 PIK58534.1 - 0.036 13.7 0.0 0.079 12.6 0.0 1.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold SRP54 PF00448.22 PIK58535.1 - 1e-69 234.1 0.2 2.2e-69 233.1 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 PIK58535.1 - 2.4e-30 105.1 2.9 2.4e-30 105.1 2.9 2.2 1 1 1 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 PIK58535.1 - 2.9e-19 69.0 4.0 2.9e-19 69.0 4.0 2.2 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 PIK58535.1 - 3.3e-07 30.1 0.5 1.2e-05 25.0 0.6 2.7 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 PIK58535.1 - 3.3e-06 27.6 0.5 0.00086 19.7 0.0 3.7 3 2 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 PIK58535.1 - 4.7e-06 26.8 0.0 9.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 PIK58535.1 - 1.7e-05 24.9 0.0 6.8e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 PIK58535.1 - 0.00021 21.7 0.0 0.0012 19.3 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 PIK58535.1 - 0.00045 19.7 1.0 0.79 9.1 0.0 2.7 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit DUF2209 PF09974.9 PIK58535.1 - 0.00057 20.2 0.2 0.0019 18.5 0.2 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) ResIII PF04851.15 PIK58535.1 - 0.0013 18.8 0.1 0.0038 17.2 0.1 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 PIK58535.1 - 0.0017 18.8 0.6 0.01 16.3 0.3 2.5 2 1 0 2 2 1 1 AAA domain APS_kinase PF01583.20 PIK58535.1 - 0.002 18.0 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase MeaB PF03308.16 PIK58535.1 - 0.0027 16.7 0.2 0.067 12.2 0.0 2.8 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 PIK58535.1 - 0.0031 16.8 0.0 0.0079 15.5 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin CLP1_P PF16575.5 PIK58535.1 - 0.0036 17.1 0.1 1.4 8.7 0.0 2.6 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 PIK58535.1 - 0.0041 17.2 1.0 0.022 14.8 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 PIK58535.1 - 0.0079 15.9 0.0 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Fe-ADH PF00465.19 PIK58535.1 - 0.014 14.3 0.1 0.049 12.4 0.0 1.9 3 0 0 3 3 3 0 Iron-containing alcohol dehydrogenase AAA_22 PF13401.6 PIK58535.1 - 0.025 14.9 0.9 0.21 11.9 0.1 3.0 3 1 0 3 3 3 0 AAA domain MobB PF03205.14 PIK58535.1 - 0.026 14.4 0.1 0.079 12.9 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.6 PIK58535.1 - 0.032 14.1 0.5 0.075 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 PIK58535.1 - 0.037 14.4 0.1 0.097 13.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 PIK58535.1 - 0.04 13.6 0.2 0.14 11.8 0.1 2.0 2 0 0 2 2 1 0 Thymidylate kinase 6PF2K PF01591.18 PIK58535.1 - 0.04 13.2 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase PduV-EutP PF10662.9 PIK58535.1 - 0.041 13.6 0.6 1.5 8.5 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 PIK58535.1 - 0.059 13.1 2.2 0.17 11.6 0.1 2.6 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.20 PIK58535.1 - 0.064 12.4 0.4 2.4 7.2 0.1 2.6 2 1 0 3 3 3 0 G-protein alpha subunit AAA_18 PF13238.6 PIK58535.1 - 0.074 13.6 0.4 0.4 11.2 0.3 2.4 2 1 0 2 2 1 0 AAA domain AAA_28 PF13521.6 PIK58535.1 - 0.17 12.2 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain YlbD_coat PF14071.6 PIK58535.1 - 2.2 8.6 9.1 3.5 7.9 1.4 4.0 3 1 0 3 3 3 0 Putative coat protein Spectrin PF00435.21 PIK58536.1 - 6.9e-65 216.1 18.9 3e-20 72.7 3.2 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 PIK58536.1 - 6.2e-51 171.2 0.5 3.3e-27 94.8 0.0 3.4 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 PIK58536.1 - 3.3e-28 97.6 0.1 1.5e-27 95.5 0.0 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 PIK58536.1 - 4.1e-10 39.3 0.1 1.7e-08 34.1 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.32 PIK58536.1 - 1.5e-07 30.5 0.1 0.00062 19.1 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK58536.1 - 2.3e-06 27.1 0.5 0.001 18.8 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 PIK58536.1 - 1e-05 25.9 0.6 4.8e-05 23.7 0.3 2.5 2 0 0 2 2 2 1 EF-hand domain pair ApoLp-III PF07464.11 PIK58536.1 - 0.039 14.0 1.4 0.45 10.6 0.1 2.9 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) CH_2 PF06294.11 PIK58536.1 - 0.13 12.4 0.0 9.7 6.4 0.0 2.9 2 0 0 2 2 2 0 CH-like domain in sperm protein DUF724 PF05266.14 PIK58536.1 - 1.2 8.9 8.1 0.43 10.4 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF724) APG6_N PF17675.1 PIK58537.1 - 0.0054 17.3 14.9 0.0054 17.3 14.9 6.2 3 2 3 6 6 6 2 Apg6 coiled-coil region UVR PF02151.19 PIK58537.1 - 0.012 15.3 2.6 0.012 15.3 2.6 4.6 4 0 0 4 4 4 0 UvrB/uvrC motif WD40 PF00400.32 PIK58538.1 - 9.6e-12 45.2 3.5 4.5e-05 24.1 0.2 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat Pkinase PF00069.25 PIK58540.1 - 2.6e-67 227.0 0.0 3.4e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58540.1 - 1.4e-41 142.5 0.0 2.1e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 PIK58540.1 - 2.7e-12 46.8 0.0 7.6e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 PIK58540.1 - 7.3e-06 25.5 0.0 1.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK58540.1 - 0.001 18.0 0.0 0.0018 17.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Fn3_assoc PF13287.6 PIK58541.1 - 3.7e-12 46.2 0.0 4.6e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Fn3 associated CHB_HEX_C_1 PF13290.6 PIK58541.1 - 9.7e-11 41.5 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain DZR PF12773.7 PIK58542.1 - 5.7e-11 42.3 23.1 1.3e-08 34.8 12.6 2.9 2 1 1 3 3 3 3 Double zinc ribbon Ank_2 PF12796.7 PIK58542.1 - 9.4e-09 35.7 0.2 1e-06 29.2 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK58542.1 - 1.8e-06 28.1 0.4 0.047 14.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 PIK58542.1 - 4.6e-06 27.1 0.1 0.026 15.1 0.0 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK58542.1 - 0.00018 21.7 0.1 0.00085 19.6 0.1 2.2 2 1 0 2 2 2 1 Ankyrin repeats (many copies) zinc_ribbon_2 PF13240.6 PIK58542.1 - 0.0013 18.4 26.8 0.016 14.9 6.9 3.7 3 0 0 3 3 3 2 zinc-ribbon domain Ank_3 PF13606.6 PIK58542.1 - 0.0015 18.8 0.0 2.4 9.0 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat zinc_ribbon_15 PF17032.5 PIK58542.1 - 0.003 18.3 20.1 0.51 11.1 0.8 3.9 4 0 0 4 4 4 3 zinc-ribbon family Cytochrom_c3_2 PF14537.6 PIK58542.1 - 0.56 10.7 9.9 0.62 10.6 1.4 3.1 2 1 1 3 3 3 0 Cytochrome c3 zf-RanBP PF00641.18 PIK58542.1 - 2.4 7.5 27.8 2.7 7.4 0.8 4.4 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others Nudix_N_2 PF14803.6 PIK58542.1 - 9.2 6.3 10.6 58 3.7 0.1 4.7 4 0 0 4 4 4 0 Nudix N-terminal zf-H2C2_2 PF13465.6 PIK58543.1 - 9.7e-23 79.5 45.2 4e-09 36.5 1.6 5.8 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58543.1 - 9.9e-18 63.5 33.1 9.9e-05 22.6 0.9 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58543.1 - 8.2e-14 51.1 35.4 0.00018 22.1 0.9 5.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK58543.1 - 1.4e-07 31.6 26.3 0.00066 19.9 0.1 5.0 4 1 1 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK58543.1 - 0.0043 17.0 1.9 0.0043 17.0 1.9 5.2 6 0 0 6 6 6 2 C2H2-type zinc finger DUF3268 PF11672.8 PIK58543.1 - 0.024 14.9 11.6 0.029 14.7 0.6 2.5 2 0 0 2 2 2 0 zinc-finger-containing domain C1_4 PF07975.12 PIK58543.1 - 0.13 12.5 22.2 0.36 11.1 2.2 4.4 2 1 3 5 5 5 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 PIK58543.1 - 1.6 9.5 19.0 6.7 7.5 2.9 3.5 2 1 1 3 3 3 0 zinc-ribbon family GFO_IDH_MocA PF01408.22 PIK58544.1 - 3.3e-21 76.3 0.0 7.6e-21 75.2 0.1 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK58544.1 - 2.3e-06 27.6 0.2 3e-05 24.0 0.1 2.4 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_7 PF13241.6 PIK58544.1 - 0.00075 19.9 0.0 0.0034 17.8 0.0 2.1 2 1 1 3 3 3 1 Putative NAD(P)-binding DDT PF02791.17 PIK58544.1 - 0.0041 17.4 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 DDT domain CoA_binding PF02629.19 PIK58544.1 - 0.17 12.6 0.0 0.41 11.4 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain DUF3395 PF11875.8 PIK58545.1 - 2.4e-23 82.8 0.8 3.8e-23 82.1 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) RVT_1 PF00078.27 PIK58546.1 - 1.3e-30 106.6 0.0 2.4e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DnaJ PF00226.31 PIK58546.1 - 9e-22 77.0 3.7 2.6e-21 75.5 2.0 2.3 2 0 0 2 2 2 1 DnaJ domain Pkinase PF00069.25 PIK58548.1 - 1.5e-53 181.9 0.1 1.8e-53 181.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58548.1 - 1.2e-28 100.1 0.1 1.5e-28 99.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK58548.1 - 3.6e-06 26.5 0.1 5.8e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 PIK58548.1 - 0.023 14.3 0.1 0.036 13.7 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK58548.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RT_RNaseH_2 PF17919.1 PIK58550.1 - 6.5e-35 119.2 0.1 2.2e-34 117.5 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58550.1 - 4.5e-32 110.5 0.0 1.2e-31 109.1 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK58550.1 - 1.8e-20 73.3 0.0 6.9e-20 71.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK58550.1 - 3.5e-20 72.5 0.1 1e-19 71.0 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK58550.1 - 2.4e-16 59.5 0.7 4.9e-16 58.6 0.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK58550.1 - 4.9e-07 29.9 0.5 1.2e-06 28.6 0.5 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK58550.1 - 0.0027 17.4 0.0 0.0093 15.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain NAAA-beta PF15508.6 PIK58553.1 - 1.1e-08 35.2 0.0 2.5e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.18 PIK58553.1 - 3.1e-07 30.4 0.0 0.0081 15.8 0.0 3.1 1 1 2 3 3 3 3 Linear amide C-N hydrolases, choloylglycine hydrolase family FAM76 PF16046.5 PIK58554.1 - 2.4e-97 325.9 66.3 1.8e-96 323.0 66.3 1.9 1 1 0 1 1 1 1 FAM76 protein Fez1 PF06818.15 PIK58554.1 - 0.0022 18.5 11.1 0.0022 18.5 11.1 2.5 2 1 0 2 2 2 1 Fez1 TF_Zn_Ribbon PF08271.12 PIK58554.1 - 0.0024 17.3 0.9 0.0024 17.3 0.9 3.5 4 1 0 4 4 4 2 TFIIB zinc-binding FAA_hydrolase_N PF09298.11 PIK58554.1 - 0.25 11.5 2.0 0.57 10.4 2.0 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal DUF1664 PF07889.12 PIK58554.1 - 2.6 8.1 7.4 5.6 7.0 7.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DZR PF12773.7 PIK58554.1 - 3.1 7.9 33.1 1.9 8.6 5.4 3.6 1 1 2 3 3 3 0 Double zinc ribbon Jnk-SapK_ap_N PF09744.9 PIK58554.1 - 3.9 7.7 27.0 0.11 12.8 16.7 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DnaJ_CXXCXGXG PF00684.19 PIK58554.1 - 6.8 7.1 30.6 11 6.4 14.1 3.1 2 0 0 2 2 2 0 DnaJ central domain zf-H2C2_2 PF13465.6 PIK58555.1 - 3.6e-06 27.2 1.0 3.6e-06 27.2 1.0 3.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58555.1 - 0.00043 20.6 10.6 0.0027 18.0 2.9 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type Mito_fiss_reg PF05308.11 PIK58555.1 - 0.0098 16.0 9.7 0.0098 16.0 9.7 3.3 3 0 0 3 3 3 2 Mitochondrial fission regulator WD40 PF00400.32 PIK58556.1 - 7e-05 23.5 11.9 0.18 12.7 0.0 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat Hira PF07569.11 PIK58556.1 - 0.012 15.3 0.1 3.2 7.4 0.0 3.1 3 0 0 3 3 3 0 TUP1-like enhancer of split Amino_oxidase PF01593.24 PIK58557.1 - 8.8e-121 404.3 0.0 2e-120 403.1 0.0 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 PIK58557.1 - 3.9e-18 65.6 0.5 1.3e-16 60.7 0.0 2.8 3 0 0 3 3 2 1 SWIRM domain NAD_binding_8 PF13450.6 PIK58557.1 - 5.2e-13 49.0 0.6 1.2e-12 47.8 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK58557.1 - 2.8e-07 30.5 0.0 4.5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 PIK58557.1 - 6.8e-07 28.8 0.3 6.8e-07 28.8 0.3 2.7 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 PIK58557.1 - 2.3e-06 27.1 2.5 6.9e-06 25.5 2.6 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK58557.1 - 3.9e-05 24.1 4.6 6.6e-05 23.4 0.8 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK58557.1 - 5.8e-05 22.0 0.8 5.8e-05 22.0 0.8 2.3 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 PIK58557.1 - 7.5e-05 22.0 2.6 0.00012 21.3 2.6 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 PIK58557.1 - 0.00012 21.6 0.1 0.00012 21.6 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 PIK58557.1 - 0.0004 19.7 1.0 0.00071 18.9 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 PIK58557.1 - 0.0015 17.9 0.3 0.0015 17.9 0.3 1.9 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK58557.1 - 0.0024 17.1 0.2 0.0047 16.2 0.2 1.4 1 0 0 1 1 1 1 Thi4 family DUF489 PF04356.12 PIK58557.1 - 0.0064 16.5 2.8 0.014 15.4 2.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF489) GIDA PF01134.22 PIK58557.1 - 0.007 15.5 0.9 0.007 15.5 0.9 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 PIK58557.1 - 0.0072 15.7 0.1 0.02 14.3 0.1 1.8 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 PIK58557.1 - 0.0091 15.1 0.2 0.014 14.5 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DUF4315 PF14193.6 PIK58557.1 - 0.017 15.1 9.1 0.47 10.5 6.3 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4315) NAD_binding_7 PF13241.6 PIK58557.1 - 0.035 14.5 0.9 0.086 13.3 0.1 2.2 2 0 0 2 2 1 0 Putative NAD(P)-binding XdhC_C PF13478.6 PIK58557.1 - 0.13 12.8 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain CmlA_N PF18456.1 PIK58557.1 - 0.14 11.4 2.7 0.29 10.4 2.7 1.4 1 0 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain TrkA_N PF02254.18 PIK58557.1 - 0.18 12.1 0.1 0.45 10.8 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain SPT16 PF08644.11 PIK58557.1 - 0.18 12.0 4.0 0.42 10.8 4.0 1.6 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DUF4715 PF15835.5 PIK58557.1 - 0.21 11.6 3.4 0.31 11.1 2.4 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4715) SlyX PF04102.12 PIK58557.1 - 0.47 11.1 5.7 1.4 9.6 4.7 2.4 2 0 0 2 2 1 0 SlyX OEP PF02321.18 PIK58557.1 - 0.54 10.0 4.1 1.9 8.3 3.5 2.1 2 0 0 2 2 2 0 Outer membrane efflux protein DUF4065 PF13274.6 PIK58557.1 - 3 8.8 5.7 2.4 9.1 1.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4065) 3HCDH_N PF02737.18 PIK58557.1 - 3.3 7.6 5.3 1.3 8.9 0.5 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain V_ATPase_I PF01496.19 PIK58557.1 - 9 4.1 10.6 1.4 6.8 6.3 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family LRR_8 PF13855.6 PIK58558.1 - 7.1e-18 64.1 25.4 7.4e-09 35.3 5.2 4.7 1 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK58558.1 - 5.6e-09 36.1 26.2 5.2e-06 26.7 2.5 4.6 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK58558.1 - 3.5e-07 29.8 16.3 0.12 13.0 0.1 6.7 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 PIK58558.1 - 6.7e-05 22.5 5.5 0.18 11.3 0.2 3.5 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 PIK58558.1 - 0.0014 18.6 1.9 0.0042 17.0 0.5 2.4 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) DUF1431 PF07248.12 PIK58558.1 - 0.11 12.8 1.9 0.11 12.8 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1431) LRR_6 PF13516.6 PIK58558.1 - 0.42 10.8 22.3 15 6.0 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich repeat PGF-CTERM PF18204.1 PIK58558.1 - 0.8 9.8 2.2 1.5 8.9 2.2 1.5 1 0 0 1 1 1 0 PGF-CTERM motif Ig_3 PF13927.6 PIK58559.1 - 3e-09 37.4 1.6 0.0017 18.9 0.0 4.4 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK58559.1 - 1.4e-08 34.9 1.5 0.041 14.2 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK58559.1 - 6.4e-07 29.5 0.2 6.7e-05 23.0 0.0 3.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58559.1 - 1.5e-06 28.2 0.5 0.00024 21.1 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain ig PF00047.25 PIK58559.1 - 7.6e-06 26.0 4.8 0.00026 21.1 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain TMEM154 PF15102.6 PIK58559.1 - 0.017 15.0 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family GST_N_2 PF13409.6 PIK58560.1 - 1.9e-21 76.1 0.0 3.8e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK58560.1 - 1.2e-10 41.2 0.0 7.2e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK58560.1 - 3.3e-08 33.6 0.0 6e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK58560.1 - 0.00052 20.2 0.0 0.001 19.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK58560.1 - 0.00075 19.9 0.0 0.028 14.8 0.0 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Spore_III_AB PF09548.10 PIK58560.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DGCR6 PF07324.11 PIK58561.1 - 3.5e-37 127.9 4.7 4.4e-37 127.6 4.7 1.0 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF2458 PF10454.9 PIK58561.1 - 1.5e-06 28.0 0.8 1.9e-06 27.7 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Arm PF00514.23 PIK58562.1 - 2.1e-77 253.0 15.2 1.1e-12 47.5 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK58562.1 - 9.4e-24 83.5 5.3 6.8e-09 36.0 0.0 5.5 5 1 0 5 5 5 4 HEAT-like repeat IBB PF01749.20 PIK58562.1 - 6.9e-23 80.9 8.9 6.9e-23 80.9 8.9 3.0 3 0 0 3 3 3 1 Importin beta binding domain HEAT_2 PF13646.6 PIK58562.1 - 8.8e-20 70.9 1.5 0.00067 20.0 0.0 5.9 4 2 2 6 6 6 5 HEAT repeats Arm_3 PF16186.5 PIK58562.1 - 3.8e-18 64.8 6.5 8.9e-18 63.6 5.7 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT PF02985.22 PIK58562.1 - 1.6e-13 49.6 6.8 0.00062 19.8 0.0 7.7 9 0 0 9 9 9 3 HEAT repeat Arm_2 PF04826.13 PIK58562.1 - 4.2e-05 23.1 0.4 1.7 8.1 0.0 4.0 1 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 PIK58562.1 - 6.1e-05 23.1 4.4 0.67 10.1 0.3 4.6 5 3 0 5 5 5 2 V-ATPase subunit H Adaptin_N PF01602.20 PIK58562.1 - 0.00023 19.9 0.0 0.007 15.0 0.0 2.8 1 1 1 2 2 2 1 Adaptin N terminal region HEAT_PBS PF03130.16 PIK58562.1 - 0.0023 18.4 1.8 42 5.2 0.0 6.1 7 0 0 7 7 6 0 PBS lyase HEAT-like repeat RICTOR_V PF14668.6 PIK58562.1 - 0.0057 16.9 0.7 27 5.1 0.0 4.7 4 1 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 Lpp-LpqN PF10738.9 PIK58562.1 - 0.05 13.1 0.2 0.11 12.0 0.2 1.5 1 0 0 1 1 1 0 Probable lipoprotein LpqN Hairy_orange PF07527.13 PIK58563.1 - 0.00028 21.0 0.0 0.00057 20.0 0.0 1.5 1 0 0 1 1 1 1 Hairy Orange Mfa2 PF08842.10 PIK58563.1 - 0.063 12.9 0.0 0.084 12.5 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2 DUF4071 PF13281.6 PIK58564.1 - 1.2e-153 511.6 0.1 2.3e-153 510.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 PIK58564.1 - 7.6e-62 209.0 0.0 2.1e-61 207.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58564.1 - 1.2e-39 136.2 0.0 2.3e-39 135.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK58564.1 - 0.0023 16.8 0.1 0.0059 15.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase TLE_N PF03920.15 PIK58564.1 - 0.11 12.6 0.2 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.18 PIK58564.1 - 4.3 7.6 6.0 0.77 10.0 1.4 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper Pkinase PF00069.25 PIK58565.1 - 2.7e-32 112.2 0.0 3.9e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58565.1 - 4.6e-16 58.9 0.0 6e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK58565.1 - 6e-05 22.5 0.5 0.00041 19.8 0.5 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK58565.1 - 0.0001 21.2 0.0 0.00019 20.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase DSPc PF00782.20 PIK58566.1 - 2.8e-14 53.1 0.0 3.9e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 PIK58566.1 - 0.00024 20.8 0.0 0.00035 20.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RRM_1 PF00076.22 PIK58566.1 - 0.0014 18.4 0.1 0.0034 17.2 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PTPlike_phytase PF14566.6 PIK58566.1 - 0.063 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 PIK58567.1 - 1.1e-40 136.9 29.3 2.8e-09 37.4 0.2 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58567.1 - 1.4e-18 67.0 2.4 0.012 15.9 0.0 5.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK58567.1 - 1.3e-05 24.3 0.3 0.17 10.8 0.0 3.8 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK58567.1 - 3.6e-05 23.7 0.2 0.0086 16.0 0.1 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 PIK58567.1 - 0.01 13.9 0.3 0.028 12.4 0.1 1.6 1 1 0 1 1 1 0 IKI3 family Coatomer_WDAD PF04053.14 PIK58567.1 - 0.031 13.3 0.3 0.57 9.2 0.1 2.7 1 1 1 2 2 2 0 Coatomer WD associated region Arg_repressor_C PF02863.18 PIK58567.1 - 0.12 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain PGM_PMM_I PF02878.16 PIK58568.1 - 6.8e-15 55.0 0.0 1.7e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 PIK58568.1 - 3.5e-10 39.9 0.4 1.2e-09 38.2 0.4 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 PIK58568.1 - 0.00015 21.9 0.4 0.00059 20.0 0.4 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 PIK58568.1 - 0.0067 17.0 0.7 0.044 14.4 0.7 2.3 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II zf-H2C2_2 PF13465.6 PIK58569.1 - 1.2e-40 136.1 89.6 7e-09 35.7 1.4 10.4 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58569.1 - 1.1e-36 123.2 90.4 1.2e-05 25.4 0.9 10.4 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK58569.1 - 1.2e-29 100.5 83.7 0.0025 18.5 0.7 10.4 10 0 0 10 10 10 10 C2H2-type zinc finger zf-met PF12874.7 PIK58569.1 - 1.4e-15 57.1 64.6 0.01 16.2 0.3 10.8 9 1 1 10 10 10 8 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK58569.1 - 6.4e-12 45.4 65.2 0.0061 16.8 0.1 11.0 10 1 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK58569.1 - 2.6e-06 27.3 84.9 0.02 14.9 0.8 10.0 10 0 0 10 10 10 7 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK58569.1 - 5.2e-05 22.9 54.4 0.011 15.5 3.0 9.5 9 1 1 10 10 10 5 zinc-finger C2H2-type GAGA PF09237.11 PIK58569.1 - 0.031 14.1 13.7 3.2 7.6 0.4 5.2 2 1 2 5 5 5 0 GAGA factor zf-C2HE PF16278.5 PIK58569.1 - 0.038 14.4 0.6 0.038 14.4 0.6 9.6 1 1 7 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 PIK58569.1 - 0.04 13.7 0.2 0.04 13.7 0.2 9.0 9 2 0 9 9 9 0 C2H2-type zinc-finger domain DUF3268 PF11672.8 PIK58569.1 - 0.23 11.8 24.3 0.19 12.1 2.8 4.4 2 1 2 5 5 5 0 zinc-finger-containing domain zf-C2H2_2 PF12756.7 PIK58569.1 - 7 7.1 65.8 2.3 8.6 1.0 8.5 1 1 7 8 8 8 0 C2H2 type zinc-finger (2 copies) gag-asp_proteas PF13975.6 PIK58570.1 - 0.00063 20.3 0.0 0.0017 18.9 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK58570.1 - 0.0008 19.4 1.4 0.0008 19.4 1.4 2.8 3 0 0 3 3 3 1 Zinc knuckle Asp_protease_2 PF13650.6 PIK58570.1 - 0.0066 17.1 0.0 0.019 15.6 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK58570.1 - 0.067 13.5 0.0 0.17 12.2 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 PIK58570.1 - 0.63 9.8 5.3 2 8.2 0.7 2.8 3 0 0 3 3 3 0 Zinc knuckle RT_RNaseH PF17917.1 PIK58571.1 - 1.8e-25 89.2 0.0 2.9e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK58571.1 - 3.1e-15 56.0 0.0 5.6e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK58571.1 - 1.4e-11 44.3 0.1 2.7e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK58571.1 - 0.0028 17.8 0.0 0.0052 17.0 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger RRM_1 PF00076.22 PIK58572.1 - 4.6e-59 196.2 0.1 4.9e-21 74.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK58572.1 - 7.3e-12 45.0 0.0 2.4e-08 33.7 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 PIK58572.1 - 6.1e-08 32.3 0.0 0.087 12.4 0.0 3.4 1 1 2 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK58572.1 - 2.3e-06 27.5 0.3 0.00024 21.1 0.0 3.5 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 PIK58572.1 - 8.2e-05 22.7 1.4 0.62 10.2 0.0 3.9 3 1 1 4 4 4 2 RNA recognition motif SET_assoc PF11767.8 PIK58572.1 - 0.027 14.1 0.1 5.3 6.7 0.0 3.0 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 PIK58572.1 - 0.11 12.6 5.2 16 5.6 0.9 3.6 2 2 1 3 3 3 0 RNA binding motif Limkain-b1 PF11608.8 PIK58572.1 - 0.12 12.5 0.2 7.6 6.7 0.0 2.7 3 0 0 3 3 3 0 Limkain b1 TFIIA PF03153.13 PIK58572.1 - 0.27 11.2 21.8 0.35 10.8 21.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 PIK58572.1 - 4.6 7.9 15.7 1.7 9.3 12.4 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NHL PF01436.21 PIK58573.1 - 6.1e-28 95.4 2.1 1.2e-05 25.0 0.0 8.2 8 0 0 8 8 8 5 NHL repeat SGL PF08450.12 PIK58573.1 - 2.9e-09 36.9 0.0 0.0029 17.2 0.0 3.4 2 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 PIK58573.1 - 6e-06 26.4 0.0 2.6 8.3 0.0 4.2 4 0 0 4 4 4 2 Arylesterase NIR_SIR_ferr PF03460.17 PIK58573.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain NTR2 PF15458.6 PIK58573.1 - 0.29 10.7 0.1 0.43 10.1 0.1 1.2 1 0 0 1 1 1 0 Nineteen complex-related protein 2 BCIP PF13862.6 PIK58574.1 - 1.3e-45 155.7 0.3 1.8e-45 155.3 0.3 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein HA2 PF04408.23 PIK58575.1 - 4.8e-25 87.9 0.1 1.3e-24 86.5 0.1 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK58575.1 - 2.4e-20 72.7 0.0 6.3e-20 71.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK58575.1 - 4.7e-12 46.2 0.0 1.1e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK58575.1 - 0.00018 21.3 0.8 0.16 11.7 0.8 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 PIK58575.1 - 0.0008 18.9 0.0 0.0017 17.8 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.6 PIK58575.1 - 0.0045 17.3 3.5 0.077 13.3 2.0 3.0 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 PIK58575.1 - 0.018 15.0 0.1 8.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 PIK58575.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 PIK58575.1 - 0.14 11.1 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 PIK58575.1 - 0.15 12.6 0.6 0.99 9.9 0.3 2.3 1 1 1 2 2 2 0 ABC transporter AAA_19 PF13245.6 PIK58575.1 - 0.2 12.0 0.5 0.56 10.5 0.5 1.8 1 1 0 1 1 1 0 AAA domain DUF872 PF05915.12 PIK58576.1 - 3.2e-21 75.6 0.1 3.7e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) DUF4713 PF15831.5 PIK58576.1 - 0.00045 20.6 0.1 0.00078 19.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) DUF3185 PF11381.8 PIK58576.1 - 0.015 15.3 2.7 1.1 9.3 2.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3185) DUF2207 PF09972.9 PIK58576.1 - 0.05 12.4 0.0 0.05 12.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3040 PF11239.8 PIK58576.1 - 0.17 12.2 0.5 0.23 11.8 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) DUF3592 PF12158.8 PIK58576.1 - 2.9 7.9 8.1 15 5.6 8.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3592) adh_short PF00106.25 PIK58577.1 - 6.8e-06 25.7 0.0 9.1e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK58577.1 - 0.0016 18.0 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SNRNP27 PF08648.12 PIK58578.1 - 1.9e-25 88.7 1.6 3.5e-25 87.8 1.6 1.4 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins FYVE PF01363.21 PIK58579.1 - 1.2e-10 41.4 12.1 1.2e-10 41.4 12.1 2.8 3 0 0 3 3 3 1 FYVE zinc finger FYVE_2 PF02318.16 PIK58579.1 - 0.0021 18.2 8.8 0.0021 18.2 8.8 1.9 2 0 0 2 2 2 1 FYVE-type zinc finger Reticulon PF02453.17 PIK58579.1 - 0.021 14.8 9.7 0.27 11.2 9.8 2.0 1 1 1 2 2 2 0 Reticulon Pex24p PF06398.11 PIK58579.1 - 0.04 12.9 13.4 0.011 14.8 9.5 1.9 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin Med8 PF10232.9 PIK58579.1 - 0.079 12.5 0.2 0.18 11.4 0.2 1.5 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF639 PF04842.12 PIK58579.1 - 1.1 8.6 5.1 0.51 9.7 1.5 1.9 1 1 0 2 2 2 0 Plant protein of unknown function (DUF639) NOB1_Zn_bind PF08772.11 PIK58579.1 - 2.5 8.3 18.2 2e+02 2.2 14.8 2.9 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like SseC PF04888.12 PIK58580.1 - 0.0078 15.8 5.7 0.011 15.4 5.7 1.1 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family DUF3130 PF11328.8 PIK58580.1 - 0.069 13.4 1.5 0.18 12.1 1.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3130 KTI12 PF08433.10 PIK58581.1 - 3.2e-20 72.7 0.1 2e-16 60.3 0.1 2.1 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_33 PF13671.6 PIK58581.1 - 1.3e-07 31.9 0.0 2.9e-06 27.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK58581.1 - 0.0011 19.3 0.0 0.0027 18.1 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain 6PF2K PF01591.18 PIK58581.1 - 0.0016 17.8 0.0 0.0034 16.7 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA PF00004.29 PIK58581.1 - 0.025 15.0 0.0 0.048 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.12 PIK58581.1 - 0.074 12.9 0.0 5 6.9 0.0 2.3 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 PIK58581.1 - 0.096 13.2 0.1 0.91 10.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain PA PF02225.22 PIK58582.1 - 1.1e-08 35.0 0.0 1.8e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 PA domain Aminotran_3 PF00202.21 PIK58583.1 - 1.2e-69 235.0 0.0 1.5e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DUF4219 PF13961.6 PIK58583.1 - 0.046 13.4 0.3 0.093 12.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Aminotran_3 PF00202.21 PIK58584.1 - 5.8e-41 140.5 0.0 6.7e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III LDcluster4 PF18306.1 PIK58586.1 - 1.5e-05 24.6 0.0 8.1e-05 22.3 0.0 2.2 2 1 0 2 2 2 1 SLOG cluster4 family TIR_2 PF13676.6 PIK58586.1 - 6.1e-05 23.6 0.0 0.00029 21.4 0.0 2.2 1 1 0 1 1 1 1 TIR domain STALD PF18185.1 PIK58586.1 - 0.12 11.7 0.3 17 4.7 0.0 2.6 3 0 0 3 3 3 0 Sir2- and TIR-associating SLOG family DUF2383 PF09537.10 PIK58587.1 - 0.045 14.1 5.7 0.1 13.0 0.0 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF2383) CCDC84 PF14968.6 PIK58587.1 - 0.077 12.6 9.4 0.091 12.4 9.4 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 CCDC74_C PF14917.6 PIK58587.1 - 4.3 7.9 14.8 6.6 7.3 9.6 2.5 1 1 1 2 2 2 0 Coiled coil protein 74, C terminal WD40 PF00400.32 PIK58588.1 - 2.4e-09 37.6 13.6 0.07 14.0 0.0 7.8 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58588.1 - 2.1e-06 28.0 0.4 0.6 10.4 0.0 5.5 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 PIK58588.1 - 7.1e-05 23.2 1.1 1.4 9.5 0.0 5.7 5 0 0 5 5 5 1 PQQ-like domain PQQ PF01011.21 PIK58588.1 - 0.0091 15.9 3.1 67 3.7 0.1 5.8 6 0 0 6 6 6 0 PQQ enzyme repeat DUF1513 PF07433.11 PIK58588.1 - 0.083 12.0 2.5 2.4 7.2 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1513) WD40_like PF17005.5 PIK58588.1 - 0.14 11.4 0.0 21 4.3 0.0 3.0 2 1 1 3 3 3 0 WD40-like domain RVT_1 PF00078.27 PIK58589.1 - 7.9e-29 100.7 0.0 1.4e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK58589.1 - 0.0025 18.4 0.0 0.012 16.3 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-RING_2 PF13639.6 PIK58590.1 - 1.5e-11 44.4 10.7 1.5e-11 44.4 10.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 PIK58590.1 - 1.1e-08 34.7 3.6 1.1e-08 34.7 3.6 2.4 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 PIK58590.1 - 1.5e-08 34.8 7.3 1.5e-08 34.8 7.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK58590.1 - 5.9e-08 32.5 5.9 1.3e-07 31.4 5.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK58590.1 - 4.4e-07 29.6 10.1 1.1e-06 28.4 10.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK58590.1 - 3.4e-06 26.8 6.9 8.5e-06 25.5 6.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK58590.1 - 2.1e-05 24.4 7.9 4.3e-05 23.4 7.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK58590.1 - 3.1e-05 23.9 3.1 0.00011 22.1 3.1 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK58590.1 - 0.00047 20.0 4.4 0.00047 20.0 4.4 2.0 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 PIK58590.1 - 0.00062 19.8 3.2 0.00062 19.8 3.2 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 PIK58590.1 - 0.12 12.5 8.6 0.67 10.2 2.3 2.7 2 0 0 2 2 2 0 Zinc-ribbon like family FANCL_C PF11793.8 PIK58590.1 - 1.3 9.2 6.3 4.9 7.4 6.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 PIK58590.1 - 4.5 7.2 7.3 10 6.0 7.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 PIK58590.1 - 9.7 6.4 11.6 0.79 9.9 6.2 2.0 2 0 0 2 2 2 0 RING-variant domain Peptidase_M17 PF00883.21 PIK58591.1 - 3.6e-52 177.6 0.0 8.6e-49 166.5 0.0 2.1 1 1 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain zf-H2C2_2 PF13465.6 PIK58592.1 - 1.9e-12 47.0 48.4 0.00012 22.3 0.7 9.1 9 1 0 9 9 9 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK58592.1 - 4.1e-12 45.8 60.2 0.02 15.3 0.4 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 PIK58592.1 - 2e-11 43.5 41.0 0.0035 17.1 0.1 6.4 6 0 0 6 6 6 5 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 PIK58592.1 - 0.00027 21.5 57.5 0.16 12.9 0.2 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-met PF12874.7 PIK58592.1 - 0.11 13.0 0.4 0.11 13.0 0.4 6.4 8 1 0 8 8 8 0 Zinc-finger of C2H2 type S1 PF00575.23 PIK58593.1 - 9.5e-33 112.4 32.0 8.5e-08 32.4 0.1 10.6 10 0 0 10 10 10 6 S1 RNA binding domain eIF3_subunit PF08597.10 PIK58593.1 - 0.017 15.0 13.2 0.05 13.5 13.2 1.7 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RNase_II_C_S1 PF18614.1 PIK58593.1 - 0.079 12.9 0.0 0.079 12.9 0.0 4.1 4 0 0 4 4 4 0 RNase II-type exonuclease C-terminal S1 domain FeoA PF04023.14 PIK58593.1 - 0.19 12.0 0.6 5.7 7.3 0.1 3.0 2 0 0 2 2 2 0 FeoA domain HpaP PF09483.10 PIK58593.1 - 0.49 10.7 4.3 0.54 10.5 0.7 2.9 3 0 0 3 3 3 0 Type III secretion protein (HpaP) Suf PF05843.14 PIK58595.1 - 2.2e-11 44.3 6.5 3.8e-07 30.4 0.8 3.0 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 PIK58595.1 - 1.4e-10 41.0 0.0 0.4 11.6 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat Ribosomal_S7 PF00177.21 PIK58595.1 - 2.6e-05 23.9 0.1 0.2 11.3 0.0 2.6 3 0 0 3 3 3 2 Ribosomal protein S7p/S5e TPR_15 PF13429.6 PIK58595.1 - 0.00031 20.0 0.1 2.1 7.5 0.1 3.4 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK58595.1 - 0.00044 20.7 0.0 1.8 9.2 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK58595.1 - 0.0008 19.3 0.2 1.5 9.1 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 PIK58595.1 - 0.0012 18.0 1.7 0.24 10.5 0.1 2.5 1 1 0 2 2 2 2 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 PIK58595.1 - 0.0018 18.8 0.1 0.48 11.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK58595.1 - 0.0049 17.0 0.3 2.1 8.8 0.0 3.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK58595.1 - 0.0068 17.0 0.0 8.1 7.2 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Vitellogenin_N PF01347.22 PIK58595.1 - 0.026 12.9 0.1 0.073 11.5 0.1 1.4 1 1 0 1 1 1 0 Lipoprotein amino terminal region TPR_MalT PF17874.1 PIK58595.1 - 0.12 11.7 0.4 0.31 10.3 0.4 1.7 1 1 0 1 1 1 0 MalT-like TPR region ATP_synth_reg PF14960.6 PIK58596.1 - 4.2e-14 51.7 0.4 5.3e-14 51.4 0.4 1.2 1 0 0 1 1 1 1 ATP synthase regulation Aa_trans PF01490.18 PIK58597.1 - 7.1e-18 64.5 5.4 4.1e-16 58.7 5.4 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein NigD_C PF17415.2 PIK58597.1 - 0.25 11.4 0.0 1.6 8.8 0.0 1.9 2 0 0 2 2 2 0 NigD-like C-terminal beta sandwich domain DUF2892 PF11127.8 PIK58597.1 - 8.6 6.5 8.8 1.2 9.2 1.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2892) Aa_trans PF01490.18 PIK58598.1 - 1.6e-31 109.5 11.9 1.8e-31 109.3 11.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3188 PF11384.8 PIK58598.1 - 6 6.7 8.2 6.1 6.6 0.5 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3188) PIP49_C PF12260.8 PIK58599.1 - 8.6e-26 90.7 1.7 8.6e-26 90.7 1.7 1.7 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 PIK58599.1 - 7.4e-11 42.2 0.1 2e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 N-term cysteine-rich ER, FAM69 Leu_zip PF15294.6 PIK58600.1 - 4.6e-108 360.9 18.3 5.2e-108 360.8 18.3 1.0 1 0 0 1 1 1 1 Leucine zipper DUF2884 PF11101.8 PIK58600.1 - 0.015 14.8 2.1 0.015 14.8 2.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2884) KELK PF15796.5 PIK58600.1 - 0.044 14.2 1.2 0.044 14.2 1.2 3.0 2 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF4349 PF14257.6 PIK58600.1 - 0.12 11.8 11.2 0.1 12.0 7.6 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) DUF406 PF04175.12 PIK58600.1 - 1 9.9 5.0 0.6 10.6 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF406) SlyX PF04102.12 PIK58600.1 - 3.4 8.4 11.8 0.47 11.1 0.4 4.4 5 0 0 5 5 5 0 SlyX Occludin_ELL PF07303.13 PIK58600.1 - 3.8 8.3 7.2 7 7.4 1.1 3.0 1 1 0 2 2 2 0 Occludin homology domain DUF4315 PF14193.6 PIK58600.1 - 4.9 7.2 12.9 2.7 8.0 1.9 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4315) GIT_CC PF16559.5 PIK58600.1 - 5.8 6.9 14.2 0.15 11.9 1.8 3.5 2 2 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CCDC-167 PF15188.6 PIK58600.1 - 7.8 6.9 16.5 0.48 10.8 1.2 3.2 3 2 0 3 3 3 0 Coiled-coil domain-containing protein 167 DUF1640 PF07798.11 PIK58600.1 - 9 6.3 14.3 1.6 8.7 9.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Mak16 PF04874.14 PIK58601.1 - 2.4e-28 98.6 19.0 2.4e-28 98.6 19.0 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.17 PIK58601.1 - 4.9e-12 46.6 2.7 2.9e-11 44.1 0.1 2.6 3 0 0 3 3 3 1 Ribosomal L28e protein family BUD22 PF09073.10 PIK58601.1 - 0.00082 18.8 13.5 0.00095 18.6 13.5 1.1 1 0 0 1 1 1 1 BUD22 AbiEi_4 PF13338.6 PIK58601.1 - 0.091 12.9 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Nop14 PF04147.12 PIK58601.1 - 0.13 10.4 18.7 0.16 10.2 18.7 1.1 1 0 0 1 1 1 0 Nop14-like family zinc_ribbon_2 PF13240.6 PIK58602.1 - 1.3e-10 40.7 10.8 6.6e-05 22.5 1.3 3.4 3 0 0 3 3 3 2 zinc-ribbon domain zf-ribbon_3 PF13248.6 PIK58602.1 - 8.8e-07 28.1 7.9 0.0099 15.3 1.0 3.1 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 PIK58602.1 - 1.7e-06 28.0 11.3 0.0028 17.6 0.1 3.0 3 0 0 3 3 3 2 Double zinc ribbon UPF0547 PF10571.9 PIK58602.1 - 0.00076 19.5 3.6 0.69 10.1 0.2 2.8 2 0 0 2 2 2 2 Uncharacterised protein family UPF0547 PDZ PF00595.24 PIK58602.1 - 0.026 14.9 0.2 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 PDZ domain Nudix_N_2 PF14803.6 PIK58602.1 - 0.088 12.7 0.5 19 5.3 0.0 3.2 2 0 0 2 2 2 0 Nudix N-terminal PDZ_6 PF17820.1 PIK58602.1 - 0.093 12.6 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 PDZ domain RNA_POL_M_15KD PF02150.16 PIK58602.1 - 0.2 11.6 5.4 3.2 7.7 0.5 2.9 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-dskA_traR PF01258.17 PIK58602.1 - 0.42 10.6 2.1 27 4.8 0.2 2.7 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger PDZ_2 PF13180.6 PIK58604.1 - 6e-07 29.7 0.1 0.0002 21.6 0.1 2.3 1 1 1 2 2 2 2 PDZ domain PDZ PF00595.24 PIK58604.1 - 8.6e-06 26.0 0.0 0.18 12.2 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK58604.1 - 0.00039 20.2 0.0 0.023 14.5 0.0 2.4 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 PIK58604.1 - 0.1 12.6 0.1 1.3 9.0 0.0 2.5 1 1 2 3 3 3 0 Tricorn protease PDZ domain FA_desaturase PF00487.24 PIK58605.1 - 5.4e-15 55.9 10.4 5.4e-15 55.9 10.4 1.8 1 1 1 2 2 2 1 Fatty acid desaturase C2-set_2 PF08205.12 PIK58607.1 - 0.03 14.4 2.1 0.12 12.5 0.0 2.4 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain C2-set_2 PF08205.12 PIK58608.1 - 5.6e-13 48.8 0.3 1.5e-05 25.0 0.0 3.0 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK58608.1 - 2.3e-09 37.7 5.4 0.0019 18.8 0.1 5.9 5 1 2 7 7 7 2 Immunoglobulin domain V-set PF07686.17 PIK58608.1 - 3.4e-06 27.2 0.1 0.048 13.8 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK58608.1 - 2.5e-05 24.4 4.4 0.0092 16.1 0.1 4.3 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK58608.1 - 0.00022 21.2 0.8 0.11 12.6 0.1 3.8 4 0 0 4 4 4 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK58608.1 - 0.0085 16.4 7.3 0.015 15.6 0.0 4.6 5 2 0 6 6 6 1 Immunoglobulin domain DUF3397 PF11877.8 PIK58608.1 - 0.031 14.5 0.6 0.091 13.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3397) Gram_pos_anchor PF00746.21 PIK58608.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Ig_5 PF16681.5 PIK58608.1 - 0.39 11.1 2.1 6.3 7.3 0.7 3.3 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.6 PIK58609.1 - 0.00019 22.0 0.2 0.0005 20.6 0.0 1.8 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK58609.1 - 0.00036 20.5 0.0 0.00079 19.4 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK58609.1 - 0.00047 20.3 0.0 0.0016 18.6 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK58609.1 - 0.0011 19.1 0.2 0.0023 18.1 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK58609.1 - 0.0054 17.0 0.1 0.021 15.1 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 PIK58609.1 - 0.009 16.0 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Pkinase_Tyr PF07714.17 PIK58610.1 - 4.2e-26 91.8 0.0 6.2e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58610.1 - 1.4e-19 70.5 0.1 3.1e-19 69.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Ig_3 PF13927.6 PIK58610.1 - 0.00096 19.7 0.3 0.2 12.3 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK58610.1 - 0.021 15.0 0.0 0.051 13.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain I-set PF07679.16 PIK58610.1 - 0.025 14.7 0.0 0.072 13.2 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 PIK58610.1 - 0.12 12.6 1.1 0.66 10.2 0.0 2.7 2 1 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK58611.1 - 7.7e-20 71.3 0.3 1.3e-19 70.6 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58611.1 - 3.2e-14 53.0 0.4 5.3e-14 52.2 0.4 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK58611.1 - 4.1e-10 40.1 5.0 1.5e-08 35.1 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK58611.1 - 5.6e-08 32.8 1.2 1e-06 28.7 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 PIK58611.1 - 6.4e-08 32.7 1.3 2.2e-07 31.0 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 PIK58611.1 - 1.3e-06 28.5 3.3 1.9e-05 24.7 0.1 3.7 4 0 0 4 4 4 1 Immunoglobulin domain Ig_2 PF13895.6 PIK58611.1 - 0.0004 20.7 9.0 0.0072 16.6 0.0 4.3 5 1 0 5 5 4 2 Immunoglobulin domain Ig_5 PF16681.5 PIK58611.1 - 0.012 16.0 8.3 0.16 12.4 0.4 4.4 4 1 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ECSCR PF15820.5 PIK58611.1 - 0.046 13.5 1.3 0.086 12.7 0.0 2.2 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator TGBp3 PF02495.17 PIK58611.1 - 0.12 12.0 5.3 5.3 6.8 0.2 3.3 3 0 0 3 3 3 0 Triple gene block 3 FeoB_associated PF12669.7 PIK58611.1 - 0.14 12.6 2.9 0.14 12.6 1.1 1.9 2 0 0 2 2 1 0 FeoB-associated Cys-rich membrane protein Ig_3 PF13927.6 PIK58613.1 - 5.9e-11 42.8 0.3 1.1e-08 35.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK58613.1 - 1.2e-08 35.1 0.4 4.3e-08 33.3 0.1 2.1 1 1 1 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58613.1 - 2.5e-08 33.9 1.3 5.3e-08 32.8 0.1 2.1 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK58613.1 - 2e-07 31.1 0.8 2.9e-06 27.3 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK58613.1 - 1.8e-05 25.0 4.8 0.0016 18.8 0.0 3.0 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK58613.1 - 0.0012 18.9 0.1 0.014 15.5 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK58613.1 - 0.0013 19.1 1.4 0.03 14.7 0.4 3.0 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 PIK58613.1 - 0.0098 16.2 1.1 0.53 10.7 0.7 2.6 2 1 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.17 PIK58614.1 - 4.2e-11 43.0 0.2 3.3e-10 40.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK58614.1 - 7.8e-11 42.4 4.8 1.1e-07 32.3 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK58614.1 - 7.8e-09 35.6 1.7 2.4e-06 27.7 0.1 3.5 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 PIK58614.1 - 8.7e-08 32.1 0.3 2.7e-06 27.3 0.2 3.1 2 1 0 2 2 2 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK58614.1 - 7.9e-07 29.1 1.4 3.9e-06 26.8 0.4 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK58614.1 - 1e-06 28.9 5.7 0.014 15.7 0.0 3.9 2 2 1 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 PIK58614.1 - 0.0024 18.2 5.4 0.023 15.1 0.4 4.0 3 2 1 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK58614.1 - 0.03 13.9 0.0 0.069 12.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain C1-set PF07654.15 PIK58614.1 - 0.037 14.4 1.4 1.6 9.2 0.7 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Adeno_E3_CR2 PF02439.15 PIK58614.1 - 0.05 13.4 0.5 0.05 13.4 0.5 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Microtub_bd PF16796.5 PIK58614.1 - 0.66 9.9 3.5 1.3 8.9 0.6 2.6 1 1 1 2 2 2 0 Microtubule binding Ig_3 PF13927.6 PIK58615.1 - 9.3e-11 42.2 0.9 8.4e-09 35.9 0.1 2.8 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK58615.1 - 2.9e-10 40.3 0.1 7.5e-10 39.0 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58615.1 - 4.3e-07 29.9 0.2 1.4e-06 28.3 0.2 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK58615.1 - 9.1e-07 29.0 0.6 2.7e-06 27.5 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 PIK58615.1 - 0.0003 21.1 3.5 0.014 15.7 1.5 3.1 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 PIK58615.1 - 0.0017 18.6 2.4 0.012 15.9 0.0 2.9 2 2 0 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 PIK58615.1 - 0.0035 17.6 1.1 1.3 9.4 1.1 2.6 1 1 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain EphA2_TM PF14575.6 PIK58615.1 - 0.037 14.9 0.0 0.098 13.6 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Izumo-Ig PF16706.5 PIK58615.1 - 0.076 13.1 0.1 0.16 12.0 0.1 1.6 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF4083 PF13314.6 PIK58615.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Death PF00531.22 PIK58616.1 - 0.0026 17.9 2.5 1.2 9.4 0.0 4.1 4 0 0 4 4 4 2 Death domain MatP PF06303.12 PIK58616.1 - 0.72 10.4 3.0 5.5 7.6 0.5 2.7 2 0 0 2 2 2 0 MatP N-terminal domain V-set PF07686.17 PIK58618.1 - 2.5e-09 37.3 0.2 0.0048 17.1 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK58618.1 - 3.7e-08 33.9 0.3 0.006 17.2 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK58618.1 - 9.7e-06 25.7 0.5 0.0059 16.8 0.0 3.3 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK58618.1 - 2.5e-05 24.3 0.1 0.0024 17.9 0.0 3.0 3 1 0 3 3 3 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK58618.1 - 0.0004 20.4 0.1 0.00094 19.2 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK58618.1 - 0.0038 17.5 0.5 0.27 11.6 0.0 3.1 2 2 1 3 3 3 1 Immunoglobulin domain RT_RNaseH_2 PF17919.1 PIK58619.1 - 4.5e-29 100.4 0.0 8.6e-29 99.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58619.1 - 5.9e-27 94.0 0.0 2.9e-26 91.8 0.0 2.1 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK58619.1 - 3.3e-23 82.1 0.0 5.5e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58619.1 - 0.0028 17.4 0.1 0.01 15.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain SprT-like PF10263.9 PIK58619.1 - 0.076 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 SprT-like family RVT_1 PF00078.27 PIK58620.1 - 5.3e-24 85.0 0.1 1.2e-23 83.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 PIK58621.1 - 2.5e-11 44.0 0.4 5.1e-09 36.6 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK58621.1 - 4.2e-10 39.8 0.3 1.9e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58621.1 - 4.1e-07 30.0 0.2 1.7e-06 28.0 0.2 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK58621.1 - 9.8e-07 29.0 2.3 0.0012 19.1 0.0 2.8 2 2 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK58621.1 - 1.8e-06 28.0 2.7 3.1e-05 24.0 0.3 3.0 2 2 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK58621.1 - 0.0001 22.3 0.6 0.0011 19.0 0.2 2.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK58621.1 - 0.0042 17.5 5.0 0.018 15.4 0.9 3.3 2 2 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 PIK58621.1 - 0.12 12.0 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Ank_2 PF12796.7 PIK58622.1 - 2.7e-26 92.0 0.4 2.7e-09 37.5 0.0 3.8 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 PIK58622.1 - 2.9e-26 90.7 4.3 2.4e-07 30.9 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 PIK58622.1 - 7.8e-26 90.1 0.6 1e-10 41.9 0.3 4.5 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK58622.1 - 6.9e-24 83.6 1.6 4.9e-08 33.1 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK58622.1 - 2.3e-23 79.7 4.7 0.00012 22.2 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Trefoil PF00088.18 PIK58623.1 - 7.4e-44 147.4 51.9 7.4e-10 38.6 6.3 5.3 5 0 0 5 5 5 5 Trefoil (P-type) domain Glyco_hydro_31 PF01055.26 PIK58623.1 - 2.8e-37 129.0 0.1 3.8e-37 128.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK58623.1 - 2.1e-30 105.3 0.1 4.1e-30 104.4 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 PIK58623.1 - 1.5e-08 34.8 1.4 3.3e-08 33.7 1.4 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like DUF1935 PF09149.10 PIK58623.1 - 0.025 14.9 0.0 8.1 6.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1935) Glyco_hydro_31 PF01055.26 PIK58624.1 - 1.2e-98 331.1 0.6 1.5e-98 330.8 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 PIK58624.1 - 0.013 15.7 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) Sigma70_r3 PF04539.16 PIK58625.1 - 0.053 13.6 0.9 0.2 11.7 0.0 2.3 3 0 0 3 3 3 0 Sigma-70 region 3 Peptidase_A17 PF05380.13 PIK58627.1 - 1.9e-52 177.5 0.0 3e-52 176.9 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase rve PF00665.26 PIK58627.1 - 1.1e-10 41.8 0.0 2.5e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK58627.1 - 1.4e-08 34.7 0.7 4.9e-08 33.0 0.1 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK58627.1 - 0.0063 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 PIK58627.1 - 0.066 13.4 0.5 0.26 11.6 0.5 2.1 1 0 0 1 1 1 0 H2C2 zinc finger RT_RNaseH PF17917.1 PIK58627.1 - 0.083 13.2 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Pkinase_Tyr PF07714.17 PIK58628.1 - 2e-42 145.2 0.0 3.2e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58628.1 - 1.5e-26 93.3 0.0 3.4e-26 92.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Ig_3 PF13927.6 PIK58628.1 - 1.7e-14 54.2 0.1 4.4e-09 36.8 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK58628.1 - 4e-10 39.9 0.1 2.4e-05 24.6 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK58628.1 - 1.1e-09 38.2 0.0 3.2e-08 33.5 0.0 3.0 4 0 0 4 4 4 1 Immunoglobulin I-set domain ig PF00047.25 PIK58628.1 - 8.8e-08 32.2 0.0 3.3e-05 24.0 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 PIK58628.1 - 0.0038 17.4 0.2 0.1 12.8 0.0 3.1 3 1 0 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK58628.1 - 0.062 13.4 0.1 3.7 7.7 0.0 3.2 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain PPR_3 PF13812.6 PIK58629.1 - 0.017 15.2 1.7 0.12 12.4 0.0 3.2 3 1 1 4 4 4 0 Pentatricopeptide repeat domain PPR_2 PF13041.6 PIK58630.1 - 9.2e-20 70.6 0.1 9.4e-13 48.1 0.0 3.2 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.6 PIK58630.1 - 4.5e-12 45.9 0.6 7.8e-06 25.9 0.0 2.6 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 PIK58630.1 - 4.8e-08 32.6 0.7 0.00043 19.9 0.0 3.9 4 0 0 4 4 4 2 PPR repeat PPR PF01535.20 PIK58630.1 - 6.5e-08 32.3 0.1 6.5e-08 32.3 0.1 4.7 7 0 0 7 7 7 1 PPR repeat T4SS_TraI PF16932.5 PIK58630.1 - 0.0015 17.8 0.2 0.0046 16.1 0.3 1.7 2 0 0 2 2 2 1 Type IV secretory system, conjugal DNA-protein transfer PPR_long PF17177.4 PIK58630.1 - 0.0016 17.8 0.0 0.006 16.0 0.0 1.9 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP Fibritin_C PF07921.12 PIK58630.1 - 0.058 13.5 0.2 0.36 11.0 0.0 2.4 3 0 0 3 3 3 0 Fibritin C-terminal region Spo0A_C PF08769.11 PIK58630.1 - 0.11 12.5 0.2 4.2 7.5 0.0 2.4 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal Ank_2 PF12796.7 PIK58631.1 - 1.1e-35 122.1 5.9 6.8e-14 52.2 0.1 4.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK58631.1 - 9.9e-34 115.3 5.4 3.6e-10 40.2 0.1 6.5 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK58631.1 - 3.4e-32 106.8 7.3 0.00025 21.2 0.0 9.2 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 PIK58631.1 - 5.8e-29 99.3 19.0 2.2e-05 24.7 0.0 8.4 8 1 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 PIK58631.1 - 5.4e-20 71.2 8.3 2.4e-07 30.9 0.1 6.1 4 2 2 6 6 6 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 PIK58631.1 - 1e-07 32.2 2.5 3e-07 30.7 2.5 1.8 1 0 0 1 1 1 1 SOCS box zf-LYAR PF08790.11 PIK58632.1 - 5.6e-15 54.9 9.2 8.8e-15 54.3 2.9 2.7 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-ACC PF17848.1 PIK58632.1 - 0.016 15.3 2.3 0.045 13.8 0.2 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain IBR PF01485.21 PIK58632.1 - 0.19 12.0 7.9 0.6 10.4 7.9 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2 PF00096.26 PIK58632.1 - 0.46 11.0 2.3 17 6.1 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Prok-RING_1 PF14446.6 PIK58632.1 - 0.61 10.1 8.7 2.2 8.3 8.7 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-TRAF PF02176.18 PIK58632.1 - 1.8 9.3 8.0 0.68 10.7 5.1 1.9 2 0 0 2 2 2 0 TRAF-type zinc finger DUF5584 PF17822.1 PIK58632.1 - 2.7 7.4 6.6 3.1 7.2 0.3 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5584) DUF4207 PF13904.6 PIK58633.1 - 9.7e-05 22.2 59.5 9.7e-05 22.2 59.5 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF4207) SIR2 PF02146.17 PIK58635.1 - 1.6e-47 161.7 0.0 2.4e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 PIK58635.1 - 0.085 12.6 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain RNase_P_p30 PF01876.16 PIK58636.1 - 1.2e-46 158.9 0.0 1.4e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 RNase P subunit p30 ArAE_1 PF06081.11 PIK58636.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 NHL PF01436.21 PIK58637.1 - 2.8e-13 49.2 2.0 2.6e-05 24.0 0.2 3.9 3 0 0 3 3 3 2 NHL repeat SGL PF08450.12 PIK58637.1 - 2.5e-05 24.0 0.1 0.77 9.3 0.0 3.4 3 1 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region ANAPC4_WD40 PF12894.7 PIK58637.1 - 0.022 15.0 0.0 0.055 13.8 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 PIK58637.1 - 0.046 13.0 0.1 0.11 11.7 0.1 1.5 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Phytase-like PF13449.6 PIK58637.1 - 0.074 13.0 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Esterase-like activity of phytase DUF5128 PF17170.4 PIK58637.1 - 0.16 11.1 0.0 0.8 8.8 0.0 1.8 1 1 0 1 1 1 0 6-bladed beta-propeller zf-C3HC4_4 PF15227.6 PIK58638.1 - 8e-09 35.5 3.5 8e-09 35.5 3.5 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 PIK58638.1 - 1.6e-08 34.3 1.7 1.6e-08 34.3 1.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK58638.1 - 2.1e-07 30.8 6.3 2.9e-07 30.4 3.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK58638.1 - 5.1e-06 26.2 3.5 5.1e-06 26.2 3.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK58638.1 - 1.5e-05 25.2 4.1 1.5e-05 25.2 4.1 2.1 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 PIK58638.1 - 0.00037 20.4 0.9 0.00037 20.4 0.9 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK58638.1 - 0.00076 19.3 4.4 0.00076 19.3 4.4 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK58638.1 - 0.0013 18.9 2.6 0.0037 17.5 2.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 PIK58638.1 - 0.0019 18.0 3.8 0.0019 18.0 3.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 PIK58638.1 - 0.0079 16.0 2.4 0.0079 16.0 2.4 1.7 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain HypA PF01155.19 PIK58638.1 - 0.05 13.6 0.5 0.1 12.7 0.5 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ANAPC11 PF12861.7 PIK58638.1 - 0.053 13.6 0.5 0.1 12.7 0.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-AD PF07776.15 PIK58638.1 - 0.078 13.2 2.4 0.17 12.1 2.4 1.6 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) A2L_zn_ribbon PF08792.10 PIK58638.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn_ribbon_17 PF17120.5 PIK58638.1 - 2 8.1 6.9 0.46 10.2 2.7 2.1 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type DEAD PF00270.29 PIK58639.1 - 1.5e-14 54.1 0.1 3.7e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK58639.1 - 2e-11 44.2 0.0 1.4e-09 38.3 0.0 3.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK58639.1 - 9.8e-08 32.2 0.0 3.4e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Forkhead PF00250.18 PIK58640.1 - 1.6e-31 108.4 0.4 2.4e-31 107.8 0.4 1.3 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 PIK58640.1 - 0.088 13.2 0.2 0.16 12.3 0.2 1.4 1 0 0 1 1 1 0 linker histone H1 and H5 family Ribosomal_L7Ae PF01248.26 PIK58641.1 - 1e-24 86.0 0.1 1.2e-24 85.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family WW PF00397.26 PIK58642.1 - 2.4e-22 78.7 20.2 3.7e-10 39.7 5.3 3.7 3 0 0 3 3 3 3 WW domain TFIIA PF03153.13 PIK58642.1 - 0.011 15.8 42.4 0.14 12.1 16.2 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAS_4 PF08448.10 PIK58642.1 - 0.14 12.4 0.1 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 PAS fold FF PF01846.19 PIK58643.1 - 5.3e-58 193.0 32.4 1.8e-12 47.3 0.7 6.3 6 0 0 6 6 6 6 FF domain RhoGAP-FF1 PF16512.5 PIK58643.1 - 4.2e-06 27.3 1.8 4.2e-06 27.3 1.8 5.2 3 2 2 5 5 5 3 p190-A and -B Rho GAPs FF domain DUF5550 PF17704.1 PIK58645.1 - 0.034 14.3 0.7 0.064 13.4 0.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5550) DUF2498 PF10692.9 PIK58647.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) THAP PF05485.12 PIK58648.1 - 3.8e-14 53.4 1.6 3.8e-14 53.4 1.6 1.8 2 0 0 2 2 1 1 THAP domain zf-C3HC4_2 PF13923.6 PIK58648.1 - 1.1e-10 41.2 9.9 2.4e-10 40.1 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK58648.1 - 1.2e-07 31.5 10.3 3e-07 30.2 10.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK58648.1 - 1.9e-05 24.9 9.1 1.9e-05 24.9 9.1 2.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK58648.1 - 0.00019 21.3 7.7 0.00044 20.1 7.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK58648.1 - 0.00088 19.2 14.5 0.0014 18.6 11.9 2.6 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK58648.1 - 0.0009 19.2 6.5 0.0025 17.8 6.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 PIK58648.1 - 0.0021 18.3 6.2 0.0061 16.8 6.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 PIK58648.1 - 0.02 15.0 2.8 0.02 15.0 2.8 2.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 PIK58648.1 - 0.021 14.7 8.2 0.047 13.6 8.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK58648.1 - 0.029 14.5 9.1 0.075 13.2 9.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PG_binding_4 PF12229.8 PIK58648.1 - 0.053 13.8 0.3 0.094 13.0 0.3 1.4 1 0 0 1 1 1 0 Putative peptidoglycan binding domain zf-Nse PF11789.8 PIK58648.1 - 0.79 9.6 7.7 0.52 10.2 4.1 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DED PF01335.21 PIK58650.1 - 1e-11 45.0 0.6 3.8e-05 23.9 0.0 2.4 2 1 0 2 2 2 2 Death effector domain Clat_adaptor_s PF01217.20 PIK58650.1 - 0.037 13.9 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Clathrin adaptor complex small chain PPTA PF01239.22 PIK58651.1 - 2.4e-53 176.4 12.9 8.2e-12 44.4 0.9 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 PIK58651.1 - 0.04 14.3 1.8 4.6 7.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4219 PF13961.6 PIK58651.1 - 0.9 9.3 12.4 5.3 6.8 1.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) PIEZO PF15917.5 PIK58655.1 - 9.1 5.7 10.6 0.39 10.1 2.4 2.4 2 0 0 2 2 2 0 Piezo WD40 PF00400.32 PIK58660.1 - 3.1e-10 40.5 25.8 5.1e-06 27.1 0.3 7.0 7 2 1 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK58660.1 - 1e-06 28.9 0.4 0.0036 17.6 0.0 4.9 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK58660.1 - 0.0029 17.0 0.1 2.8 7.2 0.0 3.7 4 1 0 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 PIK58660.1 - 0.0031 16.3 0.0 0.39 9.4 0.0 2.5 3 0 0 3 3 3 2 Nup133 N terminal like CPSF_A PF03178.15 PIK58660.1 - 0.025 13.9 0.0 0.064 12.6 0.0 1.7 1 1 0 1 1 1 0 CPSF A subunit region WD40 PF00400.32 PIK58661.1 - 3.9e-09 37.0 1.7 0.34 11.9 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat GAF PF01590.26 PIK58662.1 - 7.2e-16 59.0 0.0 1.3e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 PIK58662.1 - 3.3e-05 24.2 0.0 4.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 GAF domain DUF5101 PF17031.5 PIK58662.1 - 0.094 12.8 1.9 0.47 10.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) GAF PF01590.26 PIK58663.1 - 2.9e-15 57.1 0.0 3.9e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 PIK58663.1 - 1.9e-09 37.9 0.0 3.1e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 PIK58663.1 - 6.8e-07 29.7 0.0 1.3e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 GAF domain EMP24_GP25L PF01105.24 PIK58664.1 - 6.4e-32 110.9 2.1 7.4e-32 110.8 2.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF658 PF04936.12 PIK58664.1 - 0.013 15.2 0.4 0.016 15.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF658) BNIP3 PF06553.12 PIK58665.1 - 1.9e-42 145.2 2.4 2.5e-42 144.8 2.4 1.1 1 0 0 1 1 1 1 BNIP3 DUF2092 PF09865.9 PIK58665.1 - 0.23 10.8 0.2 0.36 10.2 0.2 1.2 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2092) Herpes_DNAp_acc PF04929.12 PIK58665.1 - 0.26 10.2 1.7 0.31 10.0 1.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Mtc PF03820.17 PIK58666.1 - 3.7e-115 384.3 1.7 1.2e-92 310.3 0.2 2.0 2 0 0 2 2 2 2 Tricarboxylate carrier Claudin_2 PF13903.6 PIK58666.1 - 0.047 13.4 1.0 0.52 10.0 1.1 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction PPP4R2 PF09184.11 PIK58667.1 - 0.0045 16.6 20.3 0.0045 16.6 20.3 3.2 3 0 0 3 3 3 1 PPP4R2 DRMBL PF07522.14 PIK58668.1 - 1.9e-21 76.3 0.1 6.8e-21 74.5 0.0 1.9 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 PIK58668.1 - 5e-07 29.4 0.0 7.8e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 PIK58668.1 - 0.0019 18.2 1.6 0.005 16.9 1.6 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily TFB6 PF17110.5 PIK58669.1 - 0.32 10.7 4.7 0.43 10.3 4.7 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2722 PF10846.8 PIK58669.1 - 0.77 8.6 11.6 0.92 8.4 11.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pox_Ag35 PF03286.14 PIK58669.1 - 1.9 8.2 10.9 2.8 7.7 10.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 PIK58669.1 - 2.5 6.1 22.6 2.8 6.0 22.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 PIK58669.1 - 4.2 5.5 17.8 4.2 5.4 17.8 1.0 1 0 0 1 1 1 0 Nop14-like family DUF4637 PF15470.6 PIK58669.1 - 4.3 7.0 8.1 6.4 6.5 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pes-10 PF07149.11 PIK58669.1 - 4.8 6.1 13.0 5.3 6.0 13.0 1.1 1 0 0 1 1 1 0 Pes-10 CDC45 PF02724.14 PIK58669.1 - 5.9 5.1 13.3 6.3 5.0 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 PIK58669.1 - 9.4 5.3 8.2 11 5.1 8.2 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 PIK58669.1 - 10 5.5 18.1 11 5.3 18.1 1.1 1 0 0 1 1 1 0 SDA1 bZIP_2 PF07716.15 PIK58670.1 - 8e-06 25.8 9.5 2.3e-05 24.4 9.5 1.8 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK58670.1 - 0.00085 19.4 11.7 0.00085 19.4 11.7 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 PIK58670.1 - 0.011 16.2 4.3 0.024 15.1 3.9 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor GDA1_CD39 PF01150.17 PIK58671.1 - 9.3e-125 416.6 0.0 1.2e-124 416.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family PIG-Y PF15159.6 PIK58671.1 - 0.12 13.4 1.6 0.67 10.9 0.2 2.6 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Ppx-GppA PF02541.16 PIK58671.1 - 0.13 11.7 0.0 5.9 6.2 0.0 2.2 2 0 0 2 2 2 0 Ppx/GppA phosphatase family DEAD PF00270.29 PIK58672.1 - 2.8e-40 137.9 0.1 5.4e-40 137.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK58672.1 - 4.1e-21 75.4 0.9 3.8e-20 72.3 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK58672.1 - 6.1e-06 26.3 0.0 2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SRCR PF00530.18 PIK58673.1 - 1.7e-92 304.4 20.1 2.9e-24 85.4 0.7 5.2 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain Lysyl_oxidase PF01186.17 PIK58673.1 - 7.3e-80 267.4 1.2 2.2e-79 265.9 0.1 2.3 2 0 0 2 2 2 1 Lysyl oxidase SRCR_2 PF15494.6 PIK58673.1 - 2.7e-22 79.1 8.9 6.6e-05 23.4 0.0 4.6 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK58673.1 - 1e-16 61.4 7.6 4.8e-06 27.1 0.0 5.1 5 0 0 5 5 5 3 Hepsin, SRCR domain NDUF_B7 PF05676.13 PIK58673.1 - 2.4 7.9 8.7 4.2 7.2 0.2 3.4 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Glyco_hydro_39 PF01229.17 PIK58674.1 - 3.8e-97 325.9 0.1 1.1e-96 324.4 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 39 fn3 PF00041.21 PIK58674.1 - 0.015 15.6 0.1 0.015 15.6 0.1 2.8 4 0 0 4 4 4 0 Fibronectin type III domain Ank_5 PF13857.6 PIK58675.1 - 2.1e-42 142.6 10.8 6.9e-15 54.9 0.2 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK58675.1 - 4.9e-35 115.6 2.1 1.1e-06 28.5 0.0 6.7 7 0 0 7 7 7 4 Ankyrin repeat Ank_2 PF12796.7 PIK58675.1 - 1.8e-33 115.0 2.1 1.4e-13 51.2 0.1 3.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 PIK58675.1 - 8.6e-33 111.4 7.7 1.4e-06 28.5 0.2 5.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 PIK58675.1 - 5.9e-32 109.6 1.0 5.5e-14 52.3 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeats (many copies) LBP_BPI_CETP_C PF02886.17 PIK58676.1 - 1.4e-21 77.0 0.1 1.7e-21 76.8 0.1 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK58677.1 - 0.051 13.2 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain 7tm_1 PF00001.21 PIK58678.1 - 4.2e-19 68.9 3.0 4.2e-19 68.9 3.0 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK58678.1 - 9e-08 32.2 5.8 1e-07 32.0 5.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK58678.1 - 2.1e-05 24.1 7.4 2.6e-05 23.7 7.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK58678.1 - 0.037 13.7 10.7 0.045 13.4 10.7 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 PIK58679.1 - 4.8e-31 108.0 7.5 1.4e-17 63.9 1.5 2.3 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58679.1 - 4.3e-10 39.4 12.2 1.3e-05 24.7 4.0 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58679.1 - 6.1e-10 39.3 7.8 5.4e-08 32.9 2.9 2.1 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 PIK58680.1 - 5.9e-43 147.1 11.8 8.3e-43 146.6 11.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58680.1 - 3.1e-11 43.2 12.5 4.4e-11 42.6 12.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58680.1 - 2.4e-07 30.8 10.1 3.4e-06 27.0 4.1 2.2 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK58680.1 - 2.9e-06 27.1 10.0 2.9e-06 27.1 10.0 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx SCAN PF02023.17 PIK58681.1 - 6.1e-14 51.6 1.0 1.7e-13 50.2 1.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2_10 PF16588.5 PIK58681.1 - 2.9e-05 23.7 1.5 5.3e-05 22.8 1.5 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 PIK58681.1 - 0.14 12.3 0.8 0.27 11.4 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.26 PIK58682.1 - 1.8e-15 57.1 0.0 2.2e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58682.1 - 0.0091 15.8 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Sulfotransfer_1 PF00685.27 PIK58683.1 - 2e-07 30.7 0.5 9.4e-07 28.6 0.1 2.0 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK58683.1 - 1.2e-06 29.1 0.2 3.6e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK58684.1 - 2.9e-07 30.2 0.2 1.7e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK58684.1 - 9.3e-07 29.4 0.2 2.2e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family Adeno_E3B PF03376.14 PIK58684.1 - 0.067 13.4 0.1 0.4 11.0 0.1 2.3 2 0 0 2 2 2 0 Adenovirus E3B protein NIPSNAP PF07978.13 PIK58685.1 - 3.4e-30 104.3 0.0 1.1e-23 83.4 0.0 2.1 2 0 0 2 2 2 2 NIPSNAP Lon_C PF05362.13 PIK58686.1 - 4.7e-77 258.2 0.1 8.9e-77 257.3 0.1 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 PIK58686.1 - 2.3e-26 93.0 0.1 3.5e-26 92.4 0.1 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 PIK58686.1 - 1.6e-20 73.9 0.0 3.6e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 PIK58686.1 - 2.2e-07 30.9 0.0 4e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 PIK58686.1 - 7.2e-05 22.6 0.0 0.00017 21.4 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_3 PF07726.11 PIK58686.1 - 0.00028 20.7 0.0 0.00073 19.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK58686.1 - 0.00093 19.6 0.3 0.0055 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 PIK58686.1 - 0.0013 18.9 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK58686.1 - 0.0039 17.5 0.0 0.047 14.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 PIK58686.1 - 0.0044 16.8 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 PIK58686.1 - 0.0045 16.0 0.0 0.0095 14.9 0.0 1.5 1 0 0 1 1 1 1 PrkA AAA domain RsgA_GTPase PF03193.16 PIK58686.1 - 0.008 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 PIK58686.1 - 0.026 14.7 0.8 0.18 11.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain SKI PF01202.22 PIK58686.1 - 0.03 14.4 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase AAA_18 PF13238.6 PIK58686.1 - 0.067 13.7 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain GCV_T PF01571.21 PIK58687.1 - 1.4e-64 217.9 0.0 2.5e-64 217.1 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 PIK58687.1 - 1.6e-55 189.2 0.1 3.4e-55 188.1 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 PIK58687.1 - 3.9e-20 71.9 0.1 7.2e-20 71.1 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain FAD_binding_3 PF01494.19 PIK58687.1 - 0.00012 21.4 0.3 0.00045 19.6 0.4 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 PIK58687.1 - 0.00048 19.3 0.6 0.00088 18.5 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain SoxG PF04268.12 PIK58687.1 - 0.00092 19.4 0.0 0.0026 17.9 0.0 1.7 1 1 1 2 2 2 1 Sarcosine oxidase, gamma subunit family Pyr_redox_2 PF07992.14 PIK58687.1 - 0.001 18.4 0.1 0.021 14.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK58687.1 - 0.003 16.9 0.2 0.27 10.5 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 PIK58687.1 - 0.0038 16.1 0.6 0.085 11.7 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 PIK58687.1 - 0.013 15.8 0.6 0.036 14.3 0.6 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK58687.1 - 0.018 14.3 0.2 0.043 13.1 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 PIK58687.1 - 0.043 14.4 1.1 10 6.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase T-box PF00907.22 PIK58688.1 - 5.4e-77 258.2 0.0 8.1e-77 257.6 0.0 1.3 1 0 0 1 1 1 1 T-box 7tm_1 PF00001.21 PIK58689.1 - 5.7e-47 160.3 9.7 5.7e-47 160.3 9.7 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58689.1 - 1.4e-19 70.5 9.8 1.9e-19 70.1 9.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58689.1 - 2.7e-09 37.2 9.9 8e-08 32.3 9.9 2.3 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK58689.1 - 4.4e-06 26.5 13.1 4.4e-06 26.5 13.1 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2208 PF09973.9 PIK58689.1 - 7.8 6.0 12.9 2 8.0 0.4 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2208) 7tm_1 PF00001.21 PIK58690.1 - 2.1e-37 128.9 10.4 2.5e-37 128.6 10.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58690.1 - 1.1e-15 57.7 10.9 1.5e-15 57.3 10.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58690.1 - 2.8e-06 27.3 14.8 1.3e-05 25.1 4.8 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srw PF10324.9 PIK58690.1 - 0.00019 20.9 13.5 0.013 14.8 13.5 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 PIK58690.1 - 0.0004 20.1 11.4 0.0004 20.1 11.4 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK58690.1 - 0.0013 18.3 7.6 0.0013 18.3 7.6 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srv PF10323.9 PIK58690.1 - 0.017 14.5 7.7 0.035 13.5 7.6 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 PIK58691.1 - 2.2e-41 142.0 9.0 2.7e-41 141.6 9.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58691.1 - 2e-13 50.4 8.3 2.7e-13 49.9 8.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58691.1 - 6.5e-07 29.4 8.6 5e-06 26.5 1.3 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK58691.1 - 1.2e-05 25.1 7.1 1.2e-05 25.1 7.1 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx SBF PF01758.16 PIK58691.1 - 0.01 15.6 6.4 0.054 13.2 0.1 3.1 3 0 0 3 3 3 0 Sodium Bile acid symporter family GWT1 PF06423.12 PIK58691.1 - 0.4 10.8 2.5 0.4 10.8 0.1 2.3 2 2 0 2 2 2 0 GWT1 Cpn60_TCP1 PF00118.24 PIK58692.1 - 1.7e-43 149.0 0.0 6.2e-28 97.7 0.0 2.8 2 1 0 2 2 2 2 TCP-1/cpn60 chaperonin family SRCR PF00530.18 PIK58693.1 - 1.4e-83 275.8 15.6 6.2e-28 97.2 0.2 4.2 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK58693.1 - 6.6e-18 65.1 13.8 0.00013 22.4 0.1 4.7 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK58693.1 - 1.1e-13 51.7 3.3 0.00084 19.8 0.6 4.7 4 0 0 4 4 4 4 Hepsin, SRCR domain SCRG1 PF15224.6 PIK58693.1 - 0.24 11.5 4.1 3 8.0 0.1 3.9 4 0 0 4 4 4 0 Scrapie-responsive protein 1 RRM_1 PF00076.22 PIK58694.1 - 1.1e-11 44.4 0.2 1.6e-11 43.9 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 PIK58694.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 PIK58694.1 - 0.008 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 PIK58694.1 - 0.028 14.0 0.0 0.039 13.5 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 PIK58694.1 - 0.17 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA binding domain RRM_occluded PF16842.5 PIK58694.1 - 0.19 11.6 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif SUIM_assoc PF16619.5 PIK58695.1 - 0.074 13.1 9.1 0.22 11.6 9.1 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 PIK58695.1 - 0.08 12.9 22.8 0.095 12.7 22.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fumarate_red_D PF02313.17 PIK58695.1 - 0.12 12.5 2.2 1.2 9.2 2.2 2.2 1 1 0 1 1 1 0 Fumarate reductase subunit D DDHD PF02862.17 PIK58695.1 - 1.5 8.9 5.2 2.3 8.3 5.2 1.3 1 0 0 1 1 1 0 DDHD domain SWI-SNF_Ssr4 PF08549.10 PIK58695.1 - 4.6 5.8 15.2 6 5.4 15.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Spt20 PF12090.8 PIK58695.1 - 9.2 5.8 22.7 13 5.3 22.7 1.2 1 0 0 1 1 1 0 Spt20 family Exonuc_VII_L PF02601.15 PIK58696.1 - 2.4 7.6 35.2 2.9 7.4 35.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit IMD PF08397.11 PIK58697.1 - 3.7e-72 242.3 4.1 5e-72 241.8 4.1 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain Vac14_Fig4_bd PF11916.8 PIK58698.1 - 9e-74 247.0 9.9 9e-74 247.0 9.9 1.7 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding DUF3802 PF12290.8 PIK58698.1 - 0.088 13.3 0.1 0.88 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3802) Vac14_Fab1_bd PF12755.7 PIK58699.1 - 1.4e-32 112.1 0.0 3.7e-31 107.6 0.0 2.4 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 PIK58699.1 - 1.9e-08 33.8 0.0 0.0038 17.3 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 PIK58699.1 - 8.6e-05 23.0 0.0 0.37 11.3 0.0 3.1 3 0 0 3 3 3 2 HEAT-like repeat Cnd1 PF12717.7 PIK58699.1 - 0.00028 21.0 0.3 0.82 9.7 0.0 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 PIK58699.1 - 0.0043 17.4 0.0 0.53 10.7 0.0 2.9 2 1 0 2 2 2 1 HEAT repeats FANCI_S2 PF14676.6 PIK58699.1 - 0.032 14.5 0.1 0.12 12.7 0.1 1.8 2 0 0 2 2 2 0 FANCI solenoid 2 Adaptin_N PF01602.20 PIK58699.1 - 0.054 12.1 0.0 0.5 8.9 0.0 2.1 1 1 0 2 2 2 0 Adaptin N terminal region TFCD_C PF12612.8 PIK58699.1 - 0.058 13.2 0.0 1.5 8.6 0.0 2.6 1 1 1 2 2 2 0 Tubulin folding cofactor D C terminal Ribosomal_L37ae PF01780.19 PIK58700.1 - 0.04 14.0 2.4 0.073 13.2 2.4 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family APO_RNA-bind PF05634.11 PIK58700.1 - 0.052 12.9 0.2 0.083 12.2 0.2 1.2 1 0 0 1 1 1 0 APO RNA-binding Integrase_H2C2 PF17921.1 PIK58700.1 - 0.088 12.9 11.1 1.1 9.4 0.2 3.7 4 0 0 4 4 4 0 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK58700.1 - 1.1 9.5 5.4 16 5.8 0.3 2.9 2 0 0 2 2 2 0 H2C2 zinc finger PMSR PF01625.21 PIK58701.1 - 1.4e-15 57.8 3.0 2.5e-15 57.0 3.0 1.4 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase LPD13 PF18825.1 PIK58701.1 - 0.03 14.1 0.3 0.035 13.9 0.3 1.1 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 13 FERM_N PF09379.10 PIK58702.1 - 1.5e-16 60.1 0.0 1e-15 57.4 0.0 2.3 2 0 0 2 2 2 1 FERM N-terminal domain zf-C3HC4_3 PF13920.6 PIK58702.1 - 2.1e-12 46.7 7.4 4.1e-12 45.8 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FERM_M PF00373.18 PIK58702.1 - 9e-12 45.4 0.1 4.1e-11 43.3 0.1 2.0 1 1 0 1 1 1 1 FERM central domain Prok-RING_4 PF14447.6 PIK58702.1 - 8.1e-07 28.8 8.0 1.9e-06 27.6 8.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 PIK58702.1 - 3.9e-05 23.4 9.8 0.00015 21.5 8.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK58702.1 - 6.3e-05 22.8 6.9 0.00014 21.7 6.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK58702.1 - 6.8e-05 22.7 5.5 6.8e-05 22.7 5.5 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK58702.1 - 0.00019 21.4 3.2 0.00019 21.4 3.2 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK58702.1 - 0.0011 19.2 8.1 0.0011 19.2 8.1 2.0 2 0 0 2 2 1 1 Ring finger domain DUF2039 PF10217.9 PIK58702.1 - 0.034 14.5 2.5 0.089 13.1 2.5 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) zf-AD PF07776.15 PIK58702.1 - 0.23 11.7 6.3 0.77 10.0 6.3 1.9 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) zf-RING_4 PF14570.6 PIK58702.1 - 0.28 11.0 6.6 0.68 9.8 6.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 PIK58702.1 - 0.55 10.4 6.9 1.9 8.7 6.9 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DZR PF12773.7 PIK58702.1 - 3.5 7.7 8.1 8.1 6.6 8.1 1.6 1 1 0 1 1 1 0 Double zinc ribbon NAGPA PF09992.9 PIK58703.1 - 6.1e-19 68.8 0.0 9.5e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Phosphodiester glycosidase LIP1 PF15904.5 PIK58703.1 - 0.22 11.9 0.6 0.9 9.9 0.1 2.1 2 0 0 2 2 2 0 LKB1 serine/threonine kinase interacting protein 1 Pkinase PF00069.25 PIK58705.1 - 1e-64 218.5 0.0 1.1e-64 218.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58705.1 - 1.6e-39 135.8 0.0 1.8e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK58705.1 - 1.4e-09 37.7 0.0 3.1e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK58705.1 - 0.00019 20.9 0.1 0.00025 20.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK58705.1 - 0.025 14.2 0.3 0.036 13.6 0.3 1.3 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 PIK58705.1 - 0.098 12.2 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 PIK58705.1 - 0.17 11.8 0.0 0.33 10.8 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family NPDC1 PF06809.11 PIK58706.1 - 1e-22 80.7 0.3 1.1e-22 80.6 0.3 1.0 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) ABA_GPCR PF12430.8 PIK58706.1 - 0.15 11.8 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor SID-1_RNA_chan PF13965.6 PIK58706.1 - 0.16 10.3 0.0 0.2 10.0 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ECR1_N PF14382.6 PIK58707.1 - 1.7e-16 59.7 0.2 3e-16 58.9 0.2 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 PIK58707.1 - 0.087 13.2 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 KH domain Choline_transpo PF04515.12 PIK58708.1 - 3.2e-95 319.1 38.2 3.2e-95 319.1 38.2 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter YbjN PF10722.9 PIK58708.1 - 0.063 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator ADK PF00406.22 PIK58709.1 - 1.5e-50 171.2 0.0 2.6e-33 115.2 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 PIK58709.1 - 4.3e-26 91.9 0.0 2.4e-14 53.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 PIK58709.1 - 1.5e-13 51.5 4.4 0.00067 20.0 0.8 4.2 3 1 0 4 4 4 3 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 PIK58709.1 - 1.4e-11 45.1 0.0 3.3e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 PIK58709.1 - 2.3e-08 34.3 0.1 4.4e-05 23.7 0.0 2.6 2 1 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.18 PIK58709.1 - 1.1e-05 25.3 0.4 0.018 14.8 0.1 2.3 2 0 0 2 2 2 2 Cytidylate kinase AAA PF00004.29 PIK58709.1 - 1.1e-05 25.9 0.0 0.091 13.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 PIK58709.1 - 1.6e-05 25.0 0.1 0.064 13.4 0.0 3.4 3 0 0 3 3 3 1 Shikimate kinase AAA_16 PF13191.6 PIK58709.1 - 1.8e-05 25.2 0.3 0.009 16.4 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain DUF5582 PF17819.1 PIK58709.1 - 5.7e-05 23.6 0.3 0.00014 22.4 0.3 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5582) SRPRB PF09439.10 PIK58709.1 - 0.0003 20.3 0.0 0.032 13.7 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit T2SSE PF00437.20 PIK58709.1 - 0.00046 19.3 0.0 0.068 12.2 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 PIK58709.1 - 0.0021 18.6 0.0 3.2 8.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_22 PF13401.6 PIK58709.1 - 0.0041 17.4 0.2 1.1 9.5 0.0 3.2 3 2 0 3 3 3 1 AAA domain AAA_23 PF13476.6 PIK58709.1 - 0.0075 16.8 0.0 0.11 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 PIK58709.1 - 0.014 15.2 0.0 5.7 6.8 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain RuvB_N PF05496.12 PIK58709.1 - 0.015 15.0 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 PIK58709.1 - 0.018 15.1 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 PIK58709.1 - 0.021 14.3 0.0 5.1 6.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 PIK58709.1 - 0.023 13.9 0.0 0.1 11.8 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 PIK58709.1 - 0.03 13.7 0.0 1 8.6 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 PIK58709.1 - 0.03 14.7 0.1 2.4 8.6 0.0 3.0 3 0 0 3 3 3 0 RNA helicase TsaE PF02367.17 PIK58709.1 - 0.031 14.3 0.0 0.96 9.5 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CoaE PF01121.20 PIK58709.1 - 0.042 13.5 0.1 5 6.8 0.0 2.8 3 0 0 3 3 3 0 Dephospho-CoA kinase Zeta_toxin PF06414.12 PIK58709.1 - 0.042 13.1 0.1 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 PIK58709.1 - 0.088 12.5 0.0 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TniB PF05621.11 PIK58709.1 - 0.14 11.5 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein Peptidase_S64 PF08192.11 PIK58710.1 - 5.7 5.3 11.6 6.6 5.1 11.6 1.3 1 0 0 1 1 1 0 Peptidase family S64 Y_phosphatase PF00102.27 PIK58711.1 - 1.5e-102 342.1 0.3 1.4e-51 175.3 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK58711.1 - 1.1e-06 28.5 0.2 0.0027 17.5 0.0 2.8 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Phage_glycop_gL PF11108.8 PIK58711.1 - 0.011 15.8 0.2 8.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Viral glycoprotein L PTPlike_phytase PF14566.6 PIK58711.1 - 0.011 15.8 0.4 0.3 11.2 0.0 3.1 3 0 0 3 3 3 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 PIK58711.1 - 0.089 12.7 0.0 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family fn3 PF00041.21 PIK58712.1 - 3.5e-11 43.3 5.8 6.7e-05 23.1 0.4 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK58712.1 - 0.00017 22.1 6.9 0.026 15.1 2.1 2.7 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain TMEM154 PF15102.6 PIK58712.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family DUF5305 PF17231.2 PIK58712.1 - 0.028 13.8 0.3 0.048 13.1 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Glycophorin_A PF01102.18 PIK58712.1 - 0.089 13.0 1.1 0.17 12.1 0.6 1.8 1 1 0 1 1 1 0 Glycophorin A DUF3377 PF11857.8 PIK58712.1 - 0.11 12.4 0.1 0.32 10.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CcmH PF03918.14 PIK58712.1 - 0.12 11.6 0.2 0.35 10.1 0.0 1.8 2 0 0 2 2 2 0 Cytochrome C biogenesis protein NACHT PF05729.12 PIK58715.1 - 1.7e-16 60.6 0.0 3.3e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK58715.1 - 0.00029 21.1 0.0 0.00077 19.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK58715.1 - 0.006 15.9 0.0 0.019 14.2 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 PIK58715.1 - 0.017 14.7 0.0 0.042 13.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 PIK58715.1 - 0.024 14.0 0.0 0.062 12.6 0.0 1.8 1 1 0 1 1 1 0 KaiC DAP3 PF10236.9 PIK58715.1 - 0.036 13.3 0.0 0.11 11.6 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.15 PIK58715.1 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 PIK58715.1 - 0.085 12.9 0.0 6.9 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK58715.1 - 0.1 12.3 0.0 0.32 10.7 0.0 1.8 1 1 1 2 2 2 0 IstB-like ATP binding protein Peptidase_S74 PF13884.6 PIK58715.1 - 0.1 12.9 0.0 3.5 8.0 0.0 3.0 3 0 0 3 3 3 0 Chaperone of endosialidase AAA_16 PF13191.6 PIK58715.1 - 0.13 12.7 0.0 3.4 8.0 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain bZIP_1 PF00170.21 PIK58716.1 - 2.4e-05 24.3 11.5 4.1e-05 23.6 11.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 PIK58716.1 - 0.00049 20.1 10.7 0.00078 19.5 10.7 1.3 1 0 0 1 1 1 1 Basic region leucine zipper Jnk-SapK_ap_N PF09744.9 PIK58716.1 - 0.023 14.9 5.6 0.025 14.8 5.6 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PCRF PF03462.18 PIK58716.1 - 0.025 14.5 0.7 0.029 14.2 0.7 1.1 1 0 0 1 1 1 0 PCRF domain HrpJ PF07201.11 PIK58716.1 - 0.035 14.4 4.3 0.048 14.0 4.3 1.1 1 0 0 1 1 1 0 HrpJ-like domain NLRC4_HD PF17889.1 PIK58718.1 - 0.064 13.6 0.1 0.14 12.5 0.0 1.6 2 0 0 2 2 2 0 NLRC4 helical domain NACHT PF05729.12 PIK58719.1 - 1.1e-17 64.4 0.0 2.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 PIK58719.1 - 0.00097 19.4 0.1 0.0031 17.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 PIK58719.1 - 0.0039 16.8 0.0 0.0098 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 PIK58719.1 - 0.01 15.1 0.0 0.038 13.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 PIK58719.1 - 0.018 14.2 0.0 0.047 12.8 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 PIK58719.1 - 0.066 13.6 0.0 2.1 8.7 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 PIK58719.1 - 0.094 12.1 0.0 0.26 10.6 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 PIK58719.1 - 0.1 12.6 0.0 8.4 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK58719.1 - 0.13 12.0 0.0 0.38 10.5 0.0 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein Kinesin PF00225.23 PIK58720.1 - 2.8e-83 279.6 1.1 2.8e-83 279.6 1.1 3.6 4 0 0 4 4 4 1 Kinesin motor domain Microtub_bind PF13931.6 PIK58720.1 - 2.6e-17 63.5 4.3 2.6e-17 63.5 4.3 6.5 3 1 4 7 7 7 1 Kinesin-associated microtubule-binding Microtub_bd PF16796.5 PIK58720.1 - 0.00019 21.4 5.3 0.0002 21.3 0.0 3.7 4 0 0 4 4 4 1 Microtubule binding DUF885 PF05960.11 PIK58720.1 - 9.1 5.8 38.6 0.01 15.5 9.0 3.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF885) Prominin PF05478.11 PIK58722.1 - 1.8e-81 274.3 5.7 2.2e-81 274.0 5.7 1.0 1 0 0 1 1 1 1 Prominin Baculo_PEP_C PF04513.12 PIK58722.1 - 0.0016 18.5 28.1 0.012 15.6 6.5 4.0 3 1 1 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus DELLA PF12041.8 PIK58722.1 - 0.0023 17.8 0.6 0.04 13.8 0.1 3.1 2 1 1 3 3 3 1 Transcriptional regulator DELLA protein N terminal Apolipoprotein PF01442.18 PIK58722.1 - 0.028 14.3 0.1 12 5.7 0.0 2.7 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain Syntaxin-5_N PF11416.8 PIK58722.1 - 0.037 13.3 0.1 0.095 12.0 0.1 1.6 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain V-SNARE_C PF12352.8 PIK58722.1 - 0.059 13.7 1.5 0.56 10.5 0.0 3.0 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Phage_holin_3_6 PF07332.11 PIK58722.1 - 0.067 13.2 2.4 0.46 10.5 0.5 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1218 PF06749.12 PIK58722.1 - 0.085 13.4 13.7 0.19 12.3 2.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) T2SSG PF08334.11 PIK58722.1 - 0.095 12.8 0.1 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein G SUR7 PF06687.12 PIK58722.1 - 0.096 12.3 8.3 0.63 9.6 1.1 3.6 3 0 0 3 3 3 0 SUR7/PalI family AIP3 PF03915.13 PIK58722.1 - 0.1 11.7 4.5 0.051 12.7 0.4 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 DUF2207 PF09972.9 PIK58722.1 - 0.13 11.0 8.4 0.59 8.8 0.2 3.1 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Laminin_II PF06009.12 PIK58722.1 - 0.21 11.6 8.0 1.7 8.6 0.2 3.9 4 0 0 4 4 4 0 Laminin Domain II MIG-14_Wnt-bd PF06664.12 PIK58722.1 - 0.29 10.3 5.5 0.15 11.3 0.8 2.3 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion ApoLp-III PF07464.11 PIK58722.1 - 0.31 11.1 9.2 2.8 8.0 2.0 3.0 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) BLOC1_2 PF10046.9 PIK58722.1 - 1.1 9.6 5.2 71 3.8 0.0 4.4 3 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_p24 PF05073.12 PIK58722.1 - 2 8.2 7.4 12 5.7 0.2 3.2 3 0 0 3 3 3 0 Baculovirus P24 capsid protein DUF1664 PF07889.12 PIK58722.1 - 2.1 8.4 6.2 5.3 7.1 0.2 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF2353 PF09789.9 PIK58723.1 - 7.7e-38 130.6 5.3 7.7e-38 130.6 5.3 2.2 2 1 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Helicase_PWI PF18149.1 PIK58723.1 - 0.46 10.7 2.9 1.4 9.1 0.1 2.6 3 0 0 3 3 3 0 N-terminal helicase PWI domain DUF2353 PF09789.9 PIK58724.1 - 2.2e-59 201.4 20.0 2.8e-59 201.0 20.0 1.0 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) DUF4482 PF14818.6 PIK58724.1 - 0.042 14.7 1.4 0.042 14.7 1.4 2.6 2 1 0 2 2 1 0 Domain of unknown function (DUF4482) COMM_domain PF07258.14 PIK58724.1 - 0.082 13.0 0.8 4.4 7.5 0.1 2.6 2 0 0 2 2 2 0 COMM domain Ca_bind_SSO6904 PF18249.1 PIK58724.1 - 0.17 12.3 0.8 0.44 10.9 0.0 2.1 3 0 0 3 3 3 0 Calcium binding protein SSO6904 DUF3603 PF12227.8 PIK58724.1 - 0.17 11.2 5.4 0.19 11.0 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3603) UPF0242 PF06785.11 PIK58724.1 - 0.28 11.3 16.2 1.9 8.6 8.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 PIK58724.1 - 0.37 11.3 23.0 1.9 9.0 11.6 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region PseudoU_synth_2 PF00849.22 PIK58724.1 - 0.64 10.1 3.4 0.82 9.7 3.4 1.3 1 1 0 1 1 1 0 RNA pseudouridylate synthase Fib_alpha PF08702.10 PIK58724.1 - 0.96 9.6 8.3 2.4 8.3 3.8 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 PIK58724.1 - 1 9.4 17.6 8.5 6.5 1.7 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein CdvA PF18822.1 PIK58724.1 - 2.8 7.8 21.2 0.25 11.1 2.6 3.6 2 1 1 3 3 3 0 CdvA-like coiled-coil domain YtxH PF12732.7 PIK58724.1 - 3.7 8.1 5.2 2.4 8.7 0.6 2.5 2 1 0 2 2 2 0 YtxH-like protein Atg14 PF10186.9 PIK58724.1 - 3.8 6.5 12.2 6.7 5.7 12.3 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nup88 PF10168.9 PIK58724.1 - 4.8 4.9 10.9 6.1 4.5 10.9 1.2 1 0 0 1 1 1 0 Nuclear pore component DUF883 PF05957.13 PIK58724.1 - 8.6 7.0 13.1 1.5 9.5 1.0 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Metal_resist PF13801.6 PIK58724.1 - 9.6 6.4 11.4 4.4 7.5 3.7 2.4 2 1 0 2 2 2 0 Heavy-metal resistance DOMON PF03351.17 PIK58725.1 - 2.9e-18 66.3 0.0 4.7e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 DOMON domain DUF948 PF06103.11 PIK58726.1 - 0.048 13.9 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) GDNF PF02351.16 PIK58727.1 - 2.9 8.9 15.7 5.1 8.1 6.5 2.4 2 0 0 2 2 2 0 GDNF/GAS1 domain Pkinase PF00069.25 PIK58728.1 - 2.2e-70 237.1 0.0 4.4e-70 236.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58728.1 - 1.3e-48 165.6 0.1 3.2e-48 164.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase MIT PF04212.18 PIK58728.1 - 1.8e-34 117.6 9.4 1.3e-21 76.4 3.3 2.7 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Kdo PF06293.14 PIK58728.1 - 0.00026 20.4 0.2 0.00046 19.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_7 PF13176.6 PIK58728.1 - 0.043 13.8 0.0 0.21 11.7 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat APH PF01636.23 PIK58728.1 - 0.055 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_2 PF07719.17 PIK58728.1 - 0.57 10.4 5.0 1.1 9.6 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK58728.1 - 0.78 9.7 3.0 3.3 7.7 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat P22_AR_N PF10547.9 PIK58728.1 - 1.1 9.6 4.0 0.81 10.0 0.6 2.3 2 0 0 2 2 2 0 P22_AR N-terminal domain Med10 PF09748.9 PIK58728.1 - 1.9 8.5 5.3 1.7 8.7 0.3 2.7 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex TPH PF13868.6 PIK58729.1 - 9.2e-22 77.0 118.0 9.2e-22 77.0 118.0 2.2 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain PhoLip_ATPase_C PF16212.5 PIK58730.1 - 7.1e-37 127.5 9.5 7.1e-37 127.5 9.5 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 PIK58730.1 - 1.4e-26 92.0 7.0 4.3e-26 90.4 7.0 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 PIK58730.1 - 1.3e-08 34.6 0.1 7.6e-08 32.1 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_C PF16212.5 PIK58731.1 - 3.1e-34 118.8 11.5 3.7e-34 118.6 11.5 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal RNA_pol_A_bac PF01000.26 PIK58732.1 - 1.9e-31 108.7 0.0 3.2e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 PIK58732.1 - 6.8e-16 57.5 0.0 1.1e-15 56.8 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF5461 PF17545.2 PIK58732.1 - 0.16 12.3 0.0 0.53 10.6 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5461) Ank PF00023.30 PIK58733.1 - 3.1e-06 27.4 0.0 6.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 PIK58733.1 - 4.6e-05 23.5 0.0 0.00027 21.1 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 PIK58733.1 - 5.2e-05 23.8 0.0 8.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK58733.1 - 0.011 16.3 0.0 0.02 15.5 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Rox3 PF08633.10 PIK58734.1 - 0.021 15.1 1.8 0.043 14.1 1.8 1.6 1 1 0 1 1 1 0 Rox3 mediator complex subunit DUF836 PF05768.14 PIK58734.1 - 0.079 13.4 0.1 0.23 11.9 0.1 1.7 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF2977 PF11192.8 PIK58734.1 - 0.096 12.8 1.3 0.33 11.1 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2977) Homeobox_KN PF05920.11 PIK58735.1 - 2.9e-16 59.1 0.3 6.4e-16 58.0 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 PIK58735.1 - 1.2e-07 31.4 1.6 4.2e-07 29.7 1.6 1.9 1 0 0 1 1 1 1 Homeodomain DNA_pol_phi PF04931.13 PIK58735.1 - 3.4 5.7 14.2 4.8 5.2 14.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi LRR_4 PF12799.7 PIK58736.1 - 3.8e-07 30.3 11.3 0.0027 18.1 3.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK58736.1 - 5.8e-07 29.2 12.5 6.8e-05 22.6 4.3 3.2 3 0 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 PIK58736.1 - 3.3e-06 26.7 0.2 1.1e-05 25.0 0.2 1.9 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 PIK58736.1 - 0.0014 18.6 5.8 2 8.7 0.1 3.7 3 0 0 3 3 3 2 Leucine Rich repeat DUF4809 PF16067.5 PIK58736.1 - 0.01 16.0 2.5 0.087 13.0 2.5 2.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4809) DUF2555 PF10742.9 PIK58736.1 - 1.6 8.6 5.9 0.81 9.6 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) LRR_1 PF00560.33 PIK58736.1 - 6.1 7.8 8.0 1.2e+02 3.9 0.3 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat DUF948 PF06103.11 PIK58736.1 - 7.1 7.0 32.8 0.78 10.0 2.9 5.6 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF4665 PF15679.5 PIK58737.1 - 0.056 14.1 1.0 0.059 14.0 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) Vps53_N PF04100.12 PIK58739.1 - 1e-154 515.1 7.6 1e-154 515.1 7.6 1.9 2 0 0 2 2 2 1 Vps53-like, N-terminal Vps54_N PF10475.9 PIK58739.1 - 1.9e-08 33.9 2.7 1.9e-08 33.9 2.7 2.1 2 1 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex VPS53_C PF16854.5 PIK58739.1 - 5.7e-05 23.1 0.0 5.7e-05 23.1 0.0 3.0 4 0 0 4 4 3 1 Vacuolar protein sorting-associated protein 53 C-terminus Laminin_II PF06009.12 PIK58739.1 - 0.0004 20.4 4.0 0.0004 20.4 4.0 2.6 3 1 0 3 3 2 1 Laminin Domain II DUF2451 PF10474.9 PIK58739.1 - 0.00061 19.7 1.3 0.0031 17.3 0.0 2.7 2 1 1 3 3 2 1 Protein of unknown function C-terminus (DUF2451) Vps51 PF08700.11 PIK58739.1 - 0.0011 19.0 0.6 0.0011 19.0 0.6 3.8 3 1 1 4 4 3 1 Vps51/Vps67 Spc7 PF08317.11 PIK58739.1 - 0.0023 16.8 4.6 0.0023 16.8 4.6 2.3 2 1 0 3 3 2 1 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 PIK58739.1 - 0.0046 17.1 2.6 0.0046 17.1 2.6 2.6 3 0 0 3 3 2 1 Tropomyosin like NBD94 PF16830.5 PIK58739.1 - 0.0074 16.7 3.1 0.025 15.0 3.1 1.9 1 0 0 1 1 1 1 Nucleotide-Binding Domain 94 of RH Sec8_exocyst PF04048.14 PIK58739.1 - 0.013 15.3 2.6 0.014 15.3 0.8 2.1 2 0 0 2 2 1 0 Sec8 exocyst complex component specific domain Snf7 PF03357.21 PIK58739.1 - 0.015 14.9 7.4 0.2 11.2 7.4 2.8 1 1 0 1 1 1 0 Snf7 Lipoprotein_7 PF01540.16 PIK58739.1 - 0.018 14.4 2.2 0.22 10.8 0.0 2.4 2 0 0 2 2 2 0 Adhesin lipoprotein Tropomyosin PF00261.20 PIK58739.1 - 0.019 14.3 4.4 0.1 11.9 2.0 2.4 2 0 0 2 2 2 0 Tropomyosin GAS PF13851.6 PIK58739.1 - 0.025 13.9 2.6 0.066 12.6 2.6 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding BORCS8 PF10167.9 PIK58739.1 - 0.045 13.7 6.0 0.32 10.9 0.5 3.7 4 0 0 4 4 3 0 BLOC-1-related complex sub-unit 8 T3SS_needle_F PF09392.10 PIK58739.1 - 0.097 12.9 0.1 1.7 8.9 0.0 3.1 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF XhlA PF10779.9 PIK58739.1 - 0.11 12.8 14.7 0.024 14.8 4.2 3.3 2 1 1 3 3 3 0 Haemolysin XhlA GrpE PF01025.19 PIK58739.1 - 0.11 12.1 5.6 0.057 13.1 2.5 2.1 2 1 0 2 2 1 0 GrpE COG5 PF10392.9 PIK58739.1 - 0.11 12.6 4.0 0.14 12.3 0.3 2.8 2 0 0 2 2 2 0 Golgi transport complex subunit 5 ING PF12998.7 PIK58739.1 - 0.17 12.5 9.6 0.054 14.1 3.6 3.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF1664 PF07889.12 PIK58739.1 - 0.23 11.5 12.3 10 6.2 5.6 4.6 2 2 2 5 5 5 0 Protein of unknown function (DUF1664) DUF4413 PF14372.6 PIK58739.1 - 0.23 11.8 1.7 1.5 9.2 0.1 3.2 4 0 0 4 4 3 0 Domain of unknown function (DUF4413) ATG16 PF08614.11 PIK58739.1 - 0.31 11.2 5.2 0.29 11.3 2.9 2.2 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 PIK58739.1 - 0.37 9.4 5.9 0.11 11.2 2.4 1.8 2 0 0 2 2 2 0 AAA domain KxDL PF10241.9 PIK58739.1 - 0.64 10.3 6.6 2.4 8.5 0.5 3.9 2 1 1 3 3 3 0 Uncharacterized conserved protein CREPT PF16566.5 PIK58739.1 - 1.1 9.5 4.7 3.9 7.6 1.5 3.3 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2570 PF10828.8 PIK58739.1 - 1.1 9.0 4.5 3.6 7.5 3.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) COG2 PF06148.11 PIK58739.1 - 1.2 9.2 9.3 1 9.5 3.8 3.5 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 PIK58739.1 - 2.6 8.1 10.3 2.5 8.1 2.5 3.9 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec34 PF04136.15 PIK58739.1 - 2.9 7.8 6.9 0.4 10.6 0.3 2.8 4 0 0 4 4 3 0 Sec34-like family DUF4200 PF13863.6 PIK58739.1 - 6 7.3 12.5 0.07 13.5 4.2 2.1 3 0 0 3 3 1 0 Domain of unknown function (DUF4200) Com_YlbF PF06133.11 PIK58739.1 - 7.1 7.3 9.7 0.42 11.2 1.6 2.8 3 0 0 3 3 2 0 Control of competence regulator ComK, YlbF/YmcA Syntaxin_2 PF14523.6 PIK58739.1 - 7.2 7.0 14.0 1.4 9.3 5.8 3.8 3 1 1 4 4 3 0 Syntaxin-like protein DUF5082 PF16888.5 PIK58739.1 - 7.5 6.9 10.6 20 5.5 3.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) SKA2 PF16740.5 PIK58739.1 - 10 6.0 9.0 1.9 8.3 1.1 3.3 2 1 2 4 4 3 0 Spindle and kinetochore-associated protein 2 SNAP-25 PF00835.19 PIK58740.1 - 2.3e-14 53.4 4.0 4.9e-14 52.4 4.0 1.6 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 PIK58740.1 - 0.00011 22.1 10.9 0.00055 19.9 10.7 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 PIK58740.1 - 0.0017 18.6 7.6 0.0053 17.0 1.4 3.0 2 2 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus OEP PF02321.18 PIK58740.1 - 0.0043 16.9 1.4 0.0043 16.9 1.4 2.0 2 0 0 2 2 2 1 Outer membrane efflux protein Snapin_Pallidin PF14712.6 PIK58740.1 - 0.069 13.6 7.4 0.099 13.1 3.2 2.3 2 0 0 2 2 2 0 Snapin/Pallidin Sec20 PF03908.13 PIK58740.1 - 0.11 12.4 3.1 0.17 11.9 1.0 2.0 2 0 0 2 2 2 0 Sec20 CCDC-167 PF15188.6 PIK58740.1 - 0.27 11.6 5.6 2.3 8.6 0.2 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DUF16 PF01519.16 PIK58740.1 - 0.79 10.2 9.5 0.88 10.1 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 SOAR PF16533.5 PIK58740.1 - 0.88 9.6 4.1 1.2 9.1 0.0 2.8 2 2 0 3 3 3 0 STIM1 Orai1-activating region Golgin_A5 PF09787.9 PIK58740.1 - 1.2 8.5 12.2 0.21 11.0 5.1 2.0 1 1 0 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.12 PIK58740.1 - 3.6 7.7 7.8 6.1 6.9 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cep57_CLD PF14073.6 PIK58740.1 - 4.9 7.1 12.5 0.44 10.5 5.7 2.5 2 2 0 2 2 2 0 Centrosome localisation domain of Cep57 DUF1077 PF06417.12 PIK58741.1 - 0.047 13.7 1.3 0.11 12.5 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1077) PRA1 PF03208.19 PIK58741.1 - 1.9 8.1 10.0 0.28 10.8 4.2 2.4 2 1 0 2 2 2 0 PRA1 family protein DUF1635 PF07795.11 PIK58742.1 - 0.0097 15.8 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) Sel1 PF08238.12 PIK58743.1 - 4.2e-36 122.6 24.7 1.8e-07 31.6 0.1 11.1 11 0 0 11 11 11 10 Sel1 repeat 7tm_1 PF00001.21 PIK58744.1 - 1.5e-09 37.6 7.6 2.1e-09 37.1 7.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK58744.1 - 0.17 11.1 6.1 0.23 10.7 6.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 PIK58745.1 - 1.5e-20 73.6 5.5 1.5e-20 73.6 5.5 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK58745.1 - 3.7e-08 33.1 4.0 5.1e-08 32.6 4.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK58745.1 - 0.027 14.2 6.1 0.036 13.8 6.1 1.2 1 0 0 1 1 1 0 Olfactory receptor HRG PF16954.5 PIK58745.1 - 7.3 7.1 9.6 0.68 10.4 1.8 2.4 2 0 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Adap_comp_sub PF00928.21 PIK58746.1 - 6.9e-20 71.5 0.1 1.8e-19 70.2 0.1 1.6 1 1 0 1 1 1 1 Adaptor complexes medium subunit family EF-hand_7 PF13499.6 PIK58747.1 - 6e-05 23.4 0.4 0.00062 20.2 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK58747.1 - 0.00017 20.9 0.1 0.00035 19.9 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK58747.1 - 0.00028 20.6 0.1 0.00086 19.0 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 PIK58747.1 - 0.00086 18.7 0.0 0.0017 17.8 0.0 1.5 1 0 0 1 1 1 1 EF hand 7tm_1 PF00001.21 PIK58748.1 - 4.3e-29 101.6 5.6 8.9e-29 100.6 5.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK58748.1 - 5.6e-05 23.0 4.8 5.6e-05 23.0 4.8 1.6 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 PIK58748.1 - 0.00014 21.6 14.2 0.00014 21.6 14.2 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 PIK58748.1 - 0.0005 19.5 10.1 0.0005 19.5 10.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 PIK58748.1 - 0.00075 18.9 0.1 0.00075 18.9 0.1 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 PIK58750.1 - 6.8e-23 81.3 1.5 1e-22 80.7 1.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK58750.1 - 4.2e-06 26.6 5.1 7.2e-06 25.8 5.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK58750.1 - 7.2e-05 22.7 0.3 0.00012 21.9 0.3 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK58750.1 - 0.00024 20.6 1.3 0.00047 19.6 1.3 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK58750.1 - 1.9 7.8 8.7 0.11 11.8 3.2 1.8 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv SSF PF00474.17 PIK58751.1 - 1.7e-36 126.0 30.5 2e-24 86.2 17.1 2.4 3 0 0 3 3 3 2 Sodium:solute symporter family SSF PF00474.17 PIK58752.1 - 6.2e-39 134.0 28.2 1.1e-37 129.9 25.5 3.0 2 1 0 2 2 2 1 Sodium:solute symporter family Ald_Xan_dh_C2 PF02738.18 PIK58753.1 - 1.7e-130 436.1 0.2 2.5e-130 435.5 0.2 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.22 PIK58753.1 - 3.1e-34 117.7 0.0 9.2e-34 116.1 0.0 1.9 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain FAD_binding_5 PF00941.21 PIK58753.1 - 1.7e-24 86.4 0.0 3.4e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 PIK58753.1 - 1.9e-24 85.8 0.1 5e-24 84.5 0.1 1.7 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain zf-C4 PF00105.18 PIK58754.1 - 3e-23 82.1 14.7 3e-23 82.1 14.7 2.5 2 1 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK58754.1 - 2.2e-18 66.6 0.0 4.2e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor RVT_1 PF00078.27 PIK58756.1 - 7.6e-05 22.3 0.1 0.00017 21.2 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C4 PF00105.18 PIK58757.1 - 6.7e-15 55.3 1.3 1.5e-14 54.2 1.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK58758.1 - 2.4e-15 56.7 0.1 4.9e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Auxin_repressed PF05564.12 PIK58758.1 - 0.44 11.3 1.8 1.3 9.8 0.0 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein OATP PF03137.20 PIK58759.1 - 1.8e-42 145.4 6.1 2.3e-42 145.0 6.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK58759.1 - 1.4e-07 31.5 8.8 1.4e-07 31.5 8.8 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK58759.1 - 6.8e-06 26.0 4.6 1.8e-05 24.6 4.6 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain UPF0542 PF15086.6 PIK58759.1 - 0.8 9.7 0.0 0.8 9.7 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 OATP PF03137.20 PIK58760.1 - 3.1e-103 345.9 12.6 2.5e-82 277.0 9.5 3.0 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK58760.1 - 6.8e-09 35.1 27.1 1.6e-06 27.3 13.7 3.1 3 1 0 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK58760.1 - 2.1e-08 34.2 9.2 2.1e-08 34.2 9.2 2.8 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK58760.1 - 8.6e-05 22.5 5.4 8.6e-05 22.5 5.4 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain ATG22 PF11700.8 PIK58760.1 - 0.22 10.1 12.4 0.3 9.7 0.5 3.2 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like OATP PF03137.20 PIK58761.1 - 9.8e-33 113.2 1.1 1.4e-32 112.7 1.1 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family OATP PF03137.20 PIK58762.1 - 3.3e-62 210.5 0.0 3.9e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK58762.1 - 5.1e-10 38.8 7.5 8.8e-07 28.2 0.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily ECF_trnsprt PF12822.7 PIK58762.1 - 0.037 14.1 6.2 0.11 12.6 1.0 2.2 2 0 0 2 2 2 0 ECF transporter, substrate-specific component DUF202 PF02656.15 PIK58762.1 - 0.051 14.0 0.6 1.4 9.4 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2207 PF09972.9 PIK58762.1 - 0.09 11.5 1.8 0.078 11.7 0.2 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF2157 PF09925.9 PIK58762.1 - 0.17 11.7 3.9 0.56 10.0 0.2 2.9 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) TraL PF07178.11 PIK58762.1 - 2.8 8.5 5.0 58 4.2 0.0 3.6 4 1 0 4 4 4 0 TraL protein DUF3611 PF12263.8 PIK58762.1 - 5 7.0 10.3 0.94 9.4 1.8 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF3611) OATP PF03137.20 PIK58763.1 - 1.8e-54 185.0 12.1 2.1e-54 184.8 12.1 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 PIK58763.1 - 6.7e-08 32.5 11.9 6.7e-08 32.5 11.9 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK58763.1 - 3.4e-06 26.9 9.0 9.4e-06 25.6 9.0 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 PIK58763.1 - 0.13 11.2 5.4 0.19 10.6 1.3 2.1 2 0 0 2 2 2 0 Major Facilitator Superfamily THOC2_N PF16134.5 PIK58764.1 - 0.016 13.9 0.0 0.029 13.0 0.0 1.4 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Arrestin_N PF00339.29 PIK58764.1 - 0.94 9.5 3.6 14 5.7 0.8 2.2 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain ATG16 PF08614.11 PIK58764.1 - 4.9 7.3 12.4 0.17 12.1 4.4 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FXR_C1 PF16096.5 PIK58764.1 - 9.5 6.5 15.2 0.87 9.8 3.9 2.8 2 1 1 3 3 3 0 Fragile X-related 1 protein C-terminal region 2 RBB1NT PF08169.11 PIK58765.1 - 6.7e-21 74.3 0.2 6.7e-21 74.3 0.2 4.3 4 1 0 5 5 5 1 RBB1NT (NUC162) domain ARID PF01388.21 PIK58765.1 - 5.7e-19 68.6 0.1 1.7e-18 67.1 0.1 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.8 PIK58765.1 - 1.8e-10 40.5 1.5 1.6e-09 37.5 1.5 2.9 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF4537 PF15057.6 PIK58765.1 - 0.0017 18.4 0.1 1.4 9.0 0.0 3.1 2 1 0 3 3 3 2 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 PIK58765.1 - 0.0022 17.7 0.3 0.0098 15.6 0.1 2.3 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain PWWP PF00855.17 PIK58765.1 - 0.0039 17.6 0.1 0.0039 17.6 0.1 7.6 5 3 0 5 5 5 1 PWWP domain TUDOR_5 PF18359.1 PIK58765.1 - 0.022 14.4 1.9 0.15 11.8 0.0 3.0 3 0 0 3 3 3 0 Histone methyltransferase Tudor domain 1 Tudor_3 PF18115.1 PIK58765.1 - 0.034 14.0 0.4 8.7 6.3 0.0 3.5 3 0 0 3 3 3 0 DNA repair protein Crb2 Tudor domain DUF2417 PF10329.9 PIK58765.1 - 0.22 10.9 0.1 1 8.7 0.1 2.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF2315 PF10231.9 PIK58766.1 - 9.2e-38 129.1 4.4 1.3e-37 128.6 4.4 1.2 1 0 0 1 1 1 1 Apoptogenic protein 1 ZU5 PF00791.20 PIK58768.1 - 1.6e-15 57.2 0.0 4.5e-15 55.8 0.0 1.8 1 1 0 1 1 1 1 ZU5 domain RT_RNaseH_2 PF17919.1 PIK58769.1 - 1.8e-18 66.4 0.0 3.6e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58769.1 - 8e-18 64.8 0.0 1.1e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK58769.1 - 1.4e-07 31.7 0.0 2.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_thumb PF06817.14 PIK58769.1 - 0.047 13.5 0.0 0.11 12.3 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase thumb domain V-set PF07686.17 PIK58770.1 - 1.2e-07 31.8 0.0 1.9e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK58770.1 - 4.9e-06 27.1 0.4 3.8e-05 24.2 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK58770.1 - 2.3e-05 24.4 0.3 4e-05 23.6 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK58770.1 - 0.0016 18.4 0.1 0.0035 17.4 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK58770.1 - 0.0021 18.2 0.8 0.58 10.4 0.2 3.0 1 1 1 2 2 2 1 Immunoglobulin domain Arm_vescicular PF18770.1 PIK58771.1 - 0.012 15.6 0.1 6.8 6.7 0.0 3.6 2 2 2 4 4 4 0 Armadillo tether-repeat of vescicular transport factor SH3_4 PF06347.13 PIK58771.1 - 0.042 13.7 2.9 19 5.1 0.0 4.2 5 0 0 5 5 5 0 Bacterial SH3 domain Fer4_13 PF13370.6 PIK58771.1 - 0.045 14.3 0.0 49 4.6 0.0 3.6 3 1 1 4 4 4 0 4Fe-4S single cluster domain of Ferredoxin I NACHT PF05729.12 PIK58773.1 - 0.00013 21.9 0.0 0.00027 20.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK58773.1 - 0.0015 18.1 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK58773.1 - 0.003 16.9 0.0 0.0065 15.8 0.0 1.5 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.9 PIK58773.1 - 0.0033 16.7 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 PIK58773.1 - 0.033 13.4 0.0 0.057 12.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK58773.1 - 0.052 13.8 0.0 0.19 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 PIK58773.1 - 0.069 12.5 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 PIK58773.1 - 0.086 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Integrase_H2C2 PF17921.1 PIK58774.1 - 4.6e-17 61.9 1.2 4.6e-17 61.9 1.2 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK58775.1 - 2e-21 76.4 0.0 6.4e-21 74.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK58775.1 - 0.00013 21.7 0.0 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK58775.1 - 0.0081 16.2 0.1 0.022 14.9 0.1 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Ribosomal_S28e PF01200.18 PIK58775.1 - 0.083 12.9 0.2 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S28e Fibrinogen_C PF00147.18 PIK58776.1 - 2.5e-32 112.5 0.6 2.9e-32 112.3 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK58777.1 - 3e-45 154.7 2.8 3.4e-45 154.5 2.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK58777.1 - 1.2 9.1 4.4 0.43 10.5 1.8 1.6 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) Fibrinogen_C PF00147.18 PIK58778.1 - 1e-50 172.6 2.5 1.2e-50 172.4 2.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK58778.1 - 0.017 15.0 1.1 0.017 15.0 1.1 1.6 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) PAS_9 PF13426.7 PIK58778.1 - 0.075 13.3 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 PAS domain Ribosomal_S10 PF00338.22 PIK58779.1 - 9.7e-20 70.6 0.0 1.1e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fibrinogen_C PF00147.18 PIK58780.1 - 1.5e-06 28.2 0.2 2.3e-06 27.6 0.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain zf-B_box PF00643.24 PIK58782.1 - 1.6e-15 56.9 35.4 7.6e-08 32.4 13.0 2.7 2 1 0 2 2 2 2 B-box zinc finger XRN1_D1 PF18332.1 PIK58782.1 - 0.043 13.6 0.4 0.097 12.4 0.4 1.5 1 0 0 1 1 1 0 Exoribonuclease Xrn1 D1 domain IBR PF01485.21 PIK58782.1 - 0.092 13.0 24.6 0.86 9.9 7.4 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DUF4298 PF14131.6 PIK58782.1 - 0.1 12.6 1.1 0.31 11.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Csm2_III-A PF03750.13 PIK58782.1 - 0.3 11.9 2.5 2.8 8.8 0.3 2.5 2 0 0 2 2 2 0 Csm2 Type III-A NfrA_C PF13283.6 PIK58783.1 - 0.14 11.7 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage N adsorption protein A C-term Fibrinogen_C PF00147.18 PIK58784.1 - 2.7e-39 135.2 0.5 1.1e-31 110.3 0.1 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58784.1 - 1.6e-05 24.8 3.7 1.6e-05 24.8 3.7 3.6 3 1 1 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK58784.1 - 7.8e-05 22.8 4.0 7.8e-05 22.8 4.0 3.6 2 2 1 3 3 3 1 EGF domain adh_short PF00106.25 PIK58785.1 - 1.4e-06 27.9 0.0 2.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK58785.1 - 1.7e-05 24.5 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase XendoU PF09412.10 PIK58785.1 - 0.023 13.9 0.1 0.033 13.4 0.1 1.5 1 0 0 1 1 1 0 Endoribonuclease XendoU THB PF18362.1 PIK58785.1 - 0.058 13.0 0.0 28 4.4 0.0 3.9 4 0 0 4 4 4 0 Tri-helix bundle domain DUF247 PF03140.15 PIK58785.1 - 0.074 12.3 0.6 0.099 11.8 0.0 1.5 2 0 0 2 2 2 0 Plant protein of unknown function Fibrinogen_C PF00147.18 PIK58786.1 - 7.9e-73 244.9 4.1 3.6e-37 128.3 0.6 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK58786.1 - 3e-05 23.9 3.7 3e-05 23.9 3.7 3.9 4 1 1 5 5 5 1 TILa domain EGF_3 PF12947.7 PIK58786.1 - 0.00016 21.8 4.1 0.00016 21.8 4.1 3.4 3 1 0 3 3 3 1 EGF domain zf-CCHC PF00098.23 PIK58787.1 - 1.2e-07 31.4 16.7 8e-05 22.5 1.1 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK58787.1 - 0.018 14.8 4.6 0.018 14.8 4.6 3.1 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK58787.1 - 0.26 11.0 15.0 0.89 9.3 0.5 3.4 1 1 2 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK58788.1 - 3.3e-42 144.5 0.2 3.9e-42 144.3 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IBP39 PF11422.8 PIK58788.1 - 0.061 13.1 0.0 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Initiator binding protein 39 kDa RVT_1 PF00078.27 PIK58789.1 - 1.5e-08 34.4 0.0 2.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.10 PIK58789.1 - 0.051 13.2 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1891) Fibrinogen_C PF00147.18 PIK58789.1 - 0.15 11.9 0.7 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Fibrinogen beta and gamma chains, C-terminal globular domain AAA_12 PF13087.6 PIK58790.1 - 2.6e-47 161.0 0.0 5.3e-47 160.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 PIK58790.1 - 1.4e-27 97.1 0.0 1.7e-13 51.0 0.0 2.6 2 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 PIK58790.1 - 9.1e-11 41.8 0.0 2.1e-10 40.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK58790.1 - 2.8e-09 37.5 0.0 8e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 PIK58790.1 - 0.00056 19.5 0.0 0.44 10.0 0.0 3.2 1 1 2 3 3 3 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 PIK58790.1 - 0.00066 19.7 0.0 0.0027 17.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 PIK58790.1 - 0.0066 16.7 0.0 0.038 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 PIK58790.1 - 0.0092 15.5 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 PIK58790.1 - 0.01 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 PIK58790.1 - 0.014 15.8 0.1 0.046 14.1 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 PIK58790.1 - 0.037 13.5 0.0 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Viral_helicase1 PF01443.18 PIK58790.1 - 0.046 13.5 0.0 9.6 5.9 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.6 PIK58790.1 - 0.061 12.7 0.0 3.5 6.9 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain CARD PF00619.21 PIK58791.1 - 1.1e-10 41.4 0.1 1.5e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 PIK58791.1 - 0.023 14.7 0.3 0.045 13.7 0.1 1.6 2 0 0 2 2 2 0 Caspase recruitment domain GramPos_pilinD3 PF16570.5 PIK58791.1 - 0.1 13.3 0.0 0.12 13.1 0.0 1.1 1 0 0 1 1 1 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain Pkinase PF00069.25 PIK58792.1 - 5.1e-67 226.0 0.3 6.4e-67 225.7 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58792.1 - 7e-52 176.3 0.3 1e-51 175.7 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK58792.1 - 0.00013 20.9 6.4 0.00041 19.2 0.0 3.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 PIK58792.1 - 0.00022 21.2 0.0 0.069 13.1 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family ACOX PF01756.19 PIK58792.1 - 0.00098 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Kinase-like PF14531.6 PIK58792.1 - 0.0012 18.3 0.2 0.002 17.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK58792.1 - 0.003 16.9 0.1 0.0057 16.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK58792.1 - 0.0033 17.1 0.3 0.0065 16.1 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 PIK58792.1 - 0.62 8.9 10.4 0.027 13.4 0.6 2.7 2 1 0 2 2 2 0 Haspin like kinase domain NPL PF17800.1 PIK58793.1 - 3.9e-11 43.4 0.3 1.7e-09 38.2 0.0 2.6 2 0 0 2 2 2 1 Nucleoplasmin-like domain Diphtheria_R PF01324.19 PIK58793.1 - 0.44 10.2 1.8 0.77 9.4 0.0 2.1 2 0 0 2 2 2 0 Diphtheria toxin, R domain zf-C2H2_4 PF13894.6 PIK58793.1 - 2.2 9.3 7.7 0.86 10.6 0.4 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Sulfatase PF00884.23 PIK58794.1 - 9.5e-20 71.2 0.5 1.2e-19 70.9 0.5 1.1 1 0 0 1 1 1 1 Sulfatase GP4 PF03010.14 PIK58794.1 - 0.015 15.2 0.5 0.024 14.6 0.0 1.6 2 0 0 2 2 2 0 GP4 Phosphodiest PF01663.22 PIK58794.1 - 0.066 12.8 0.1 0.074 12.6 0.1 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase EI24 PF07264.11 PIK58794.1 - 0.11 12.8 0.1 0.16 12.2 0.1 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Fimbrial_CS1 PF04449.12 PIK58795.1 - 0.053 13.7 0.4 0.12 12.5 0.4 1.5 1 0 0 1 1 1 0 CS1 type fimbrial major subunit Glyco_transf_90 PF05686.12 PIK58796.1 - 7.8e-99 331.3 0.3 9.9e-99 330.9 0.3 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 PIK58796.1 - 0.12 12.8 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Lectin_C PF00059.21 PIK58797.1 - 0.17 12.6 1.7 0.34 11.7 1.0 1.8 2 0 0 2 2 2 0 Lectin C-type domain Lectin_C PF00059.21 PIK58798.1 - 0.0071 17.1 1.0 0.048 14.4 0.3 2.3 2 0 0 2 2 2 1 Lectin C-type domain Peptidase_S32 PF05579.13 PIK58798.1 - 0.23 10.6 0.0 0.34 10.0 0.0 1.1 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 UAA PF08449.11 PIK58800.1 - 2.6e-74 250.2 14.3 3.1e-74 249.9 14.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 PIK58800.1 - 0.052 13.7 21.4 0.47 10.6 10.3 3.0 2 1 1 3 3 3 0 EamA-like transporter family 7TMR-DISM_7TM PF07695.11 PIK58800.1 - 0.16 11.8 22.3 0.069 13.0 13.0 2.2 1 1 1 2 2 2 0 7TM diverse intracellular signalling Lactamase_B PF00753.27 PIK58801.1 - 1.2e-14 54.8 2.0 6.3e-14 52.4 2.0 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK58801.1 - 0.013 15.0 0.6 0.025 14.1 0.6 1.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain DRMBL PF07522.14 PIK58802.1 - 4.2e-17 62.3 0.3 9.3e-17 61.2 0.3 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 PIK58802.1 - 0.00041 20.2 0.0 0.00083 19.2 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Glyco_hydro_47 PF01532.20 PIK58803.1 - 3.2e-28 98.8 1.6 1.4e-19 70.4 0.1 3.4 2 1 1 3 3 3 3 Glycosyl hydrolase family 47 Glyco_hydro_47 PF01532.20 PIK58804.1 - 1e-16 60.9 0.0 1.3e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF563 PF04577.14 PIK58805.1 - 1.2e-26 94.2 1.2 2e-26 93.4 1.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) FRG PF08867.11 PIK58805.1 - 0.21 12.6 0.2 0.21 12.6 0.2 2.6 3 0 0 3 3 3 0 FRG domain Hormone_recep PF00104.30 PIK58806.1 - 2.1e-43 148.3 0.6 3.2e-43 147.7 0.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF4520 PF15016.6 PIK58806.1 - 0.021 14.9 0.6 0.097 12.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4520) FSA_C PF10479.9 PIK58806.1 - 5.4 5.0 7.9 8.4 4.4 7.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sulfotransfer_2 PF03567.14 PIK58807.1 - 0.00069 19.6 0.3 0.00083 19.3 0.3 1.4 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK58807.1 - 0.01 15.3 0.1 0.023 14.2 0.0 1.6 2 0 0 2 2 2 0 Sulfotransferase domain B PF02216.16 PIK58807.1 - 0.012 15.6 0.8 0.029 14.4 0.8 1.6 1 0 0 1 1 1 0 B domain PNMA PF14893.6 PIK58808.1 - 0.00024 20.6 0.0 0.00029 20.3 0.0 1.1 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.17 PIK58808.1 - 0.012 15.8 0.4 0.024 14.9 0.0 1.7 2 0 0 2 2 2 0 Retrotransposon gag protein DUF4211 PF13926.6 PIK58808.1 - 0.029 14.4 0.2 0.068 13.2 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4211) RVT_1 PF00078.27 PIK58809.1 - 2.4e-12 46.9 0.0 4.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK58809.1 - 2.5e-08 34.4 0.0 4.4e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK58809.1 - 5.9e-05 23.6 0.0 0.00011 22.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease rve PF00665.26 PIK58810.1 - 9.2e-22 77.5 0.0 2.4e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK58810.1 - 2.2e-20 72.5 2.0 5.9e-20 71.1 2.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK58810.1 - 0.00014 21.6 0.5 0.00051 19.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK58810.1 - 0.032 14.5 0.5 0.1 12.9 0.5 1.9 1 0 0 1 1 1 0 H2C2 zinc finger Sod_Fe_N PF00081.22 PIK58810.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Ras PF00071.22 PIK58811.1 - 1.3e-53 180.9 0.1 1.5e-53 180.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK58811.1 - 6.8e-27 94.1 0.0 1.1e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK58811.1 - 1.3e-10 41.1 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK58811.1 - 0.00033 20.7 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK58811.1 - 0.00068 19.2 0.0 0.0023 17.5 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 PIK58811.1 - 0.0026 17.1 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region IBN_N PF03810.19 PIK58812.1 - 9.6e-10 38.2 0.0 4.2e-09 36.2 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 PIK58812.1 - 3e-07 30.6 0.4 2.9e-06 27.4 0.0 2.9 3 0 0 3 3 3 1 Exportin 1-like protein RIX1 PF08167.12 PIK58812.1 - 3.4e-06 26.9 0.7 0.34 10.6 0.0 5.1 4 1 1 5 5 5 2 rRNA processing/ribosome biogenesis DUF3385 PF11865.8 PIK58812.1 - 0.086 12.8 2.8 1.5 8.7 0.0 4.0 6 0 0 6 6 6 0 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 PIK58812.1 - 0.2 12.2 3.1 12 6.5 0.1 4.3 4 0 0 4 4 4 0 HEAT-like repeat HEAT PF02985.22 PIK58812.1 - 0.41 11.0 1.4 1.1e+02 3.5 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat Sec7_N PF12783.7 PIK58812.1 - 1.1 9.2 5.0 0.72 9.8 0.8 3.1 4 1 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Na_Pi_cotrans PF02690.15 PIK58814.1 - 2.6e-12 47.0 14.5 3.4e-12 46.7 13.2 2.0 1 1 0 1 1 1 1 Na+/Pi-cotransporter ApoO PF09769.9 PIK58814.1 - 0.32 11.0 1.1 1 9.4 1.1 1.9 1 0 0 1 1 1 0 Apolipoprotein O Homeodomain PF00046.29 PIK58815.1 - 1.2e-18 66.7 1.4 1.2e-18 66.7 1.4 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 PIK58815.1 - 0.061 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain TTL PF03133.15 PIK58816.1 - 4.6e-22 78.5 0.0 9.4e-10 38.1 0.0 2.3 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family Cadherin-like PF12733.7 PIK58816.1 - 0.0032 18.0 0.0 0.011 16.2 0.0 1.9 2 0 0 2 2 2 1 Cadherin-like beta sandwich domain PC-Esterase PF13839.6 PIK58816.1 - 0.012 15.3 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p DUF4536 PF15055.6 PIK58816.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) TRAP-delta PF05404.12 PIK58817.1 - 6e-62 207.9 0.0 7.2e-62 207.7 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) FHA PF00498.26 PIK58818.1 - 4.2e-18 65.5 0.0 1.2e-17 64.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 PIK58818.1 - 0.021 15.1 0.0 0.12 12.7 0.0 2.3 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain IFRD PF05004.13 PIK58819.1 - 1e-95 320.4 7.1 1.3e-95 320.0 7.1 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 PIK58819.1 - 1.5e-16 60.7 6.6 4e-16 59.3 0.1 2.9 3 0 0 3 3 3 1 Interferon-related protein conserved region PALP PF00291.25 PIK58820.1 - 3.8e-63 213.6 0.1 4.7e-63 213.3 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Abhydrolase_1 PF00561.20 PIK58821.1 - 2.5e-29 102.7 0.3 8.5e-21 74.8 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK58821.1 - 2.7e-20 74.0 0.1 5.3e-20 73.0 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK58821.1 - 5.6e-15 55.3 0.3 1.8e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 PIK58821.1 - 0.0059 16.3 0.1 0.03 14.0 0.1 2.0 1 1 0 1 1 1 1 Putative esterase DUF2048 PF09752.9 PIK58821.1 - 0.006 15.7 0.2 0.016 14.4 0.0 1.7 2 0 0 2 2 2 1 Abhydrolase domain containing 18 Palm_thioest PF02089.15 PIK58821.1 - 0.013 15.4 0.0 0.038 13.8 0.0 1.8 1 1 0 1 1 1 0 Palmitoyl protein thioesterase TSP_1 PF00090.19 PIK58822.1 - 1.7e-23 82.6 30.1 4.3e-13 49.2 11.0 4.5 4 1 1 5 5 5 2 Thrombospondin type 1 domain Viral_RdRp_C PF17501.2 PIK58822.1 - 1.3 9.5 7.7 3.7 8.1 0.1 2.8 3 0 0 3 3 3 0 Viral RNA-directed RNA polymerase Kazal_2 PF07648.15 PIK58824.1 - 4.2e-26 90.8 15.0 1.7e-09 37.7 1.4 3.3 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK58824.1 - 5.3e-19 68.0 17.7 5.1e-07 29.6 2.8 3.4 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain UCH PF00443.29 PIK58825.1 - 1.6e-15 57.3 0.0 1.8e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 PIK58826.1 - 8e-39 133.7 1.7 8.2e-39 133.6 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase CS PF04969.16 PIK58826.1 - 6.3e-11 43.1 9.3 3.2e-10 40.9 5.0 2.5 2 0 0 2 2 2 1 CS domain zf-MYND PF01753.18 PIK58826.1 - 2e-08 34.2 18.4 2e-08 34.2 18.4 2.5 3 0 0 3 3 3 1 MYND finger UCH_1 PF13423.6 PIK58826.1 - 2e-06 27.7 0.7 1.1e-05 25.2 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 PIK58826.1 - 6.7e-06 25.9 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal NOA36 PF06524.12 PIK58826.1 - 0.25 10.6 20.1 0.44 9.8 9.9 2.4 2 0 0 2 2 2 0 NOA36 protein Ribosomal_60s PF00428.19 PIK58826.1 - 0.39 11.3 10.2 0.73 10.5 8.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein CotH PF08757.11 PIK58826.1 - 0.55 9.7 6.7 1.2 8.6 6.7 1.4 1 0 0 1 1 1 0 CotH kinase protein DUF4820 PF16091.5 PIK58826.1 - 0.96 8.8 9.7 0.42 9.9 6.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) zf-C6H2 PF15801.5 PIK58826.1 - 1.1 9.7 24.9 2.7 8.4 15.7 3.0 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding Myc_N PF01056.18 PIK58826.1 - 1.6 8.6 15.2 1.7 8.4 8.3 2.3 2 0 0 2 2 2 0 Myc amino-terminal region Phage_spike PF18715.1 PIK58826.1 - 5.5 7.1 5.8 0.3 11.2 0.3 1.8 2 0 0 2 2 1 0 Phage spike trimer wnt PF00110.19 PIK58827.1 - 4.2e-52 177.7 28.3 4.6e-52 177.5 28.3 1.0 1 0 0 1 1 1 1 wnt family TSP_1 PF00090.19 PIK58828.1 - 4e-31 107.0 84.8 4.5e-12 46.0 5.9 6.8 6 2 0 6 6 6 5 Thrombospondin type 1 domain GyrI-like PF06445.15 PIK58829.1 - 0.0077 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 GyrI-like small molecule binding domain EGF PF00008.27 PIK58830.1 - 6.1e-129 419.7 280.7 1.1e-09 38.4 7.7 20.3 19 1 0 19 19 19 19 EGF-like domain hEGF PF12661.7 PIK58830.1 - 4.4e-79 258.7 245.8 1.6e-06 28.5 4.0 22.1 20 1 0 20 20 20 19 Human growth factor-like EGF EGF_CA PF07645.15 PIK58830.1 - 2.8e-54 181.1 299.2 1.9e-06 28.0 9.0 19.4 14 4 5 19 19 19 18 Calcium-binding EGF domain EGF_2 PF07974.13 PIK58830.1 - 3.4e-28 97.7 331.6 0.0019 18.5 11.4 19.6 19 1 0 19 19 19 19 EGF-like domain EGF_3 PF12947.7 PIK58830.1 - 2.2e-11 43.7 272.5 0.0008 19.5 9.1 20.0 17 4 2 19 19 19 14 EGF domain cEGF PF12662.7 PIK58830.1 - 0.0028 17.6 3.8 0.02 14.8 0.5 22.1 20 4 0 20 20 20 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK58830.1 - 7.3 7.0 262.7 0.039 14.2 5.6 19.2 10 3 9 19 19 19 0 Coagulation Factor Xa inhibitory site DUF4588 PF15251.6 PIK58831.1 - 2.5e-63 214.2 5.2 4.3e-63 213.4 5.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) tRNA_int_end_N2 PF12928.7 PIK58834.1 - 1.6e-10 41.0 0.1 4.4e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term AIG1 PF04548.16 PIK58835.1 - 1.9e-30 105.8 0.1 3e-30 105.2 0.1 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK58835.1 - 1.4e-09 38.0 0.1 2e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 PIK58835.1 - 3.6e-05 23.0 0.1 4.5e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 PIK58835.1 - 0.0006 20.2 0.0 0.00093 19.6 0.0 1.3 1 0 0 1 1 1 1 RNA helicase Dynamin_N PF00350.23 PIK58835.1 - 0.00085 19.4 4.1 0.15 12.1 0.0 2.5 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 PIK58835.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 PIK58835.1 - 0.0019 18.1 0.2 0.003 17.5 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 PIK58835.1 - 0.0064 17.0 0.0 0.009 16.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 PIK58835.1 - 0.0069 15.9 0.2 0.011 15.3 0.2 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_10 PF12846.7 PIK58835.1 - 0.012 14.5 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Septin PF00735.18 PIK58835.1 - 0.023 14.0 0.2 0.036 13.4 0.2 1.4 1 0 0 1 1 1 0 Septin Gtr1_RagA PF04670.12 PIK58835.1 - 0.024 14.0 0.5 0.04 13.3 0.1 1.5 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Ras PF00071.22 PIK58835.1 - 0.028 14.0 0.1 0.048 13.2 0.1 1.4 1 0 0 1 1 1 0 Ras family Guanylate_kin PF00625.21 PIK58835.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Guanylate kinase NMT1_3 PF16868.5 PIK58835.1 - 0.051 13.0 0.1 0.063 12.7 0.1 1.1 1 0 0 1 1 1 0 NMT1-like family Sigma54_activat PF00158.26 PIK58835.1 - 0.085 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Roc PF08477.13 PIK58835.1 - 0.093 12.9 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Peptidase_C30 PF05409.13 PIK58835.1 - 0.11 11.8 0.2 0.19 11.0 0.2 1.5 1 1 0 1 1 1 0 Coronavirus endopeptidase C30 AAA_18 PF13238.6 PIK58835.1 - 0.13 12.9 0.0 0.21 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4218 PF13960.6 PIK58836.1 - 0.00024 20.7 0.2 0.00058 19.4 0.3 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4218) RT_RNaseH_2 PF17919.1 PIK58837.1 - 2.1e-37 127.2 0.0 4.1e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK58837.1 - 1.6e-35 121.6 0.0 3.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK58837.1 - 2.5e-27 95.8 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HlyIII PF03006.20 PIK58838.1 - 7.4e-45 153.4 20.8 9e-45 153.1 20.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related HTH_6 PF01418.17 PIK58840.1 - 0.032 14.2 0.3 0.18 11.8 0.1 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain, rpiR family DUF2095 PF09868.9 PIK58840.1 - 0.19 11.7 0.0 0.52 10.3 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) TPR_MLP1_2 PF07926.12 PIK58842.1 - 0.0052 16.8 4.5 0.0052 16.8 4.5 2.1 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein DUF3475 PF11961.8 PIK58842.1 - 0.2 11.7 2.9 17 5.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) GIT_CC PF16559.5 PIK58842.1 - 0.25 11.2 4.2 1.1 9.1 4.1 2.2 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 PIK58842.1 - 0.71 9.9 4.6 2.6 8.1 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Imm43 PF15570.6 PIK58842.1 - 1.2 9.1 5.0 3.4 7.7 0.3 2.2 1 1 1 2 2 2 0 Immunity protein 43 Exonuc_VII_L PF02601.15 PIK58842.1 - 6 6.3 9.7 9.1 5.7 9.5 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit V-set PF07686.17 PIK58844.1 - 8.6e-09 35.5 1.5 0.001 19.2 0.1 3.6 4 0 0 4 4 4 2 Immunoglobulin V-set domain C1-set PF07654.15 PIK58844.1 - 2e-08 34.5 4.9 0.0069 16.7 0.2 3.6 3 0 0 3 3 3 2 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK58844.1 - 5.6e-07 29.5 1.7 0.0019 18.2 0.1 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK58844.1 - 6.5e-07 29.6 3.2 0.31 11.4 0.2 5.0 4 2 1 5 5 5 3 Immunoglobulin domain Ig_3 PF13927.6 PIK58844.1 - 3.8e-06 27.4 7.6 0.25 11.9 0.1 5.4 4 1 0 4 4 4 1 Immunoglobulin domain I-set PF07679.16 PIK58844.1 - 1.6e-05 24.9 1.6 2.4 8.3 0.1 4.4 4 0 0 4 4 4 2 Immunoglobulin I-set domain ig PF00047.25 PIK58844.1 - 0.00045 20.3 8.1 0.59 10.4 0.7 5.1 4 1 1 5 5 5 1 Immunoglobulin domain Sigma_reg_N PF13800.6 PIK58844.1 - 0.032 14.5 5.2 0.068 13.5 1.0 3.2 3 1 1 4 4 4 0 Sigma factor regulator N-terminal RVT_1 PF00078.27 PIK58846.1 - 1.2e-11 44.5 0.1 7.5e-07 28.9 0.0 2.7 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) GIY-YIG PF01541.24 PIK58846.1 - 1e-10 41.7 0.2 0.00042 20.5 0.0 3.1 3 0 0 3 3 3 2 GIY-YIG catalytic domain PRANC PF09372.10 PIK58846.1 - 0.00036 20.8 1.2 1.6 9.1 0.1 3.0 2 0 0 2 2 2 2 PRANC domain Arm-DNA-bind_2 PF12167.8 PIK58846.1 - 0.0031 17.4 0.0 6.7 6.7 0.0 3.2 4 0 0 4 4 4 2 Arm DNA-binding domain DUF2922 PF11148.8 PIK58846.1 - 0.012 15.3 1.1 75 3.2 0.0 4.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2922) DUF1848 PF08902.11 PIK58846.1 - 0.017 14.8 3.1 0.87 9.3 2.8 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1848) Pkinase_Tyr PF07714.17 PIK58847.1 - 1.7e-51 175.0 0.0 2.2e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58847.1 - 4.6e-26 91.7 0.0 6.8e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH3_2 PF07653.17 PIK58847.1 - 9.3e-07 28.4 0.0 2.9e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK58847.1 - 1.7e-06 27.5 0.0 2.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK58847.1 - 1e-05 25.3 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.14 PIK58847.1 - 0.0063 15.9 0.0 0.0099 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK58847.1 - 0.044 12.6 0.1 0.095 11.5 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase adh_short_C2 PF13561.6 PIK58849.1 - 1.1e-44 152.8 0.0 1.4e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK58849.1 - 2.5e-40 138.0 0.0 2.9e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK58849.1 - 0.00097 19.1 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 PIK58849.1 - 0.081 12.3 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) HLH PF00010.26 PIK58850.1 - 8.8e-13 48.0 1.4 1.4e-12 47.3 1.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 PIK58850.1 - 1.5e-09 37.9 0.4 4.3e-09 36.4 0.4 1.8 1 0 0 1 1 1 1 Hairy Orange Folate_rec PF03024.14 PIK58851.1 - 2.1e-06 27.7 6.6 0.0001 22.2 4.7 2.0 1 1 1 2 2 2 2 Folate receptor family ALG3 PF05208.13 PIK58852.1 - 5.2e-137 457.1 27.2 7.4e-137 456.5 27.2 1.2 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.6 PIK58852.1 - 0.00061 19.2 33.3 0.0011 18.4 33.3 1.3 1 1 0 1 1 1 1 EpsG family RINT1_TIP1 PF04437.13 PIK58853.1 - 1.1e-117 394.0 11.5 1.1e-117 394.0 11.5 1.7 2 0 0 2 2 2 1 RINT-1 / TIP-1 family NLRC4_HD PF17889.1 PIK58853.1 - 0.039 14.3 0.9 9 6.7 0.0 3.3 3 0 0 3 3 3 0 NLRC4 helical domain SesA PF17107.5 PIK58853.1 - 0.057 13.6 1.8 5.4 7.2 0.2 3.5 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Mad3_BUB1_I PF08311.12 PIK58854.1 - 4e-39 133.4 0.1 1.1e-38 132.0 0.1 1.8 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 PIK58854.1 - 8e-17 61.5 0.0 1.9e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.11 PIK58854.1 - 0.017 15.2 0.1 0.12 12.6 0.0 2.3 2 0 0 2 2 2 0 Mad3/BUB1 homology region 2 Pkinase_fungal PF17667.1 PIK58854.1 - 0.024 13.4 0.0 0.024 13.4 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Mad3_BUB1_I_2 PF17014.5 PIK58854.1 - 0.03 14.4 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein RIO1 PF01163.22 PIK58854.1 - 0.16 11.6 0.0 0.16 11.6 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Atg14 PF10186.9 PIK58854.1 - 0.66 9.0 10.4 1.7 7.6 10.4 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nup88 PF10168.9 PIK58854.1 - 3.6 5.3 14.6 2.5 5.8 12.4 1.7 2 0 0 2 2 2 0 Nuclear pore component MBOAT PF03062.19 PIK58855.1 - 2.9e-37 128.8 14.8 2.9e-37 128.8 14.8 2.3 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Phage_Orf51 PF06194.11 PIK58855.1 - 0.032 14.3 1.6 0.088 12.8 1.6 1.7 1 0 0 1 1 1 0 Phage Conserved Open Reading Frame 51 DHDPS PF00701.22 PIK58856.1 - 1.8e-32 112.2 0.0 2.7e-19 69.0 0.0 2.0 2 0 0 2 2 2 2 Dihydrodipicolinate synthetase family CDC45 PF02724.14 PIK58857.1 - 4.6 5.4 13.2 4.9 5.3 13.2 1.0 1 0 0 1 1 1 0 CDC45-like protein zf-H2C2_2 PF13465.6 PIK58858.1 - 1.8e-12 47.0 10.3 3.7e-08 33.4 1.8 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK58858.1 - 3.3e-09 36.8 8.3 0.00059 20.4 1.9 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK58858.1 - 1.1e-05 25.6 18.2 0.0001 22.5 3.1 3.2 3 1 0 3 3 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK58858.1 - 5e-05 23.5 2.6 0.00012 22.3 2.6 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK58858.1 - 0.00022 21.1 6.9 0.077 13.0 0.9 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK58858.1 - 0.00031 20.4 3.9 0.014 15.2 0.2 2.3 2 0 0 2 2 2 2 zinc-finger C2H2-type GAGA PF09237.11 PIK58858.1 - 0.0038 17.0 2.1 0.012 15.4 1.3 2.0 1 1 1 2 2 2 1 GAGA factor zf-H2C2_5 PF13909.6 PIK58858.1 - 0.013 15.2 0.4 0.013 15.2 0.4 3.4 3 1 0 3 3 2 0 C2H2-type zinc-finger domain Zn-C2H2_12 PF18112.1 PIK58858.1 - 0.015 15.7 2.1 2.2 8.8 0.4 2.9 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FYVE PF01363.21 PIK58858.1 - 0.048 13.8 1.7 0.087 13.0 1.7 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-C2H2_jaz PF12171.8 PIK58858.1 - 0.091 13.1 0.5 0.091 13.1 0.5 2.8 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_12 PF18658.1 PIK58858.1 - 0.11 12.1 0.1 0.25 10.9 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger C2H2-type zf-BED PF02892.15 PIK58858.1 - 0.13 12.3 0.3 0.13 12.3 0.3 2.6 1 1 1 2 2 2 0 BED zinc finger DUF1043 PF06295.12 PIK58858.1 - 0.34 10.9 3.9 1.7 8.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) zf-C2H2_3rep PF18868.1 PIK58858.1 - 0.52 11.0 4.0 1.6 9.4 0.3 2.7 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Rad50_zn_hook PF04423.14 PIK58858.1 - 1.4 8.8 4.8 0.27 11.1 0.6 2.0 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-met PF12874.7 PIK58858.1 - 1.7 9.1 10.8 0.44 11.0 0.6 2.9 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf-CHCC PF10276.9 PIK58858.1 - 2.3 8.3 4.9 20 5.3 0.5 2.3 2 0 0 2 2 2 0 Zinc-finger domain DUF3523 PF12037.8 PIK58859.1 - 1.5e-103 345.8 23.0 2.4e-103 345.1 23.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 PIK58859.1 - 1.1e-19 71.2 0.0 1.1e-18 68.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK58859.1 - 0.00032 21.1 3.3 0.0085 16.5 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 PIK58859.1 - 0.00059 20.1 6.3 0.094 13.0 0.0 3.7 2 2 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 PIK58859.1 - 0.0021 17.5 0.2 0.0096 15.3 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 PIK58859.1 - 0.0037 17.4 0.1 0.0037 17.4 0.1 2.3 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 PIK58859.1 - 0.0039 16.9 0.0 0.0088 15.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Zot PF05707.12 PIK58859.1 - 0.011 15.3 0.1 0.41 10.3 0.0 2.6 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) ATPase PF06745.13 PIK58859.1 - 0.017 14.5 0.0 0.061 12.7 0.0 1.9 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 PIK58859.1 - 0.023 14.7 0.0 0.1 12.6 0.0 2.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 PIK58859.1 - 0.033 14.0 0.0 0.096 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA+ lid domain RNA_helicase PF00910.22 PIK58859.1 - 0.052 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 PIK58859.1 - 0.057 13.4 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 PIK58859.1 - 0.059 12.9 0.0 0.47 9.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 PIK58859.1 - 0.064 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 PIK58859.1 - 0.13 12.0 0.0 0.13 12.0 0.0 3.0 2 1 0 2 2 1 0 AAA domain Dynactin_p62 PF05502.13 PIK58859.1 - 5.5 5.6 13.0 9.6 4.9 13.0 1.3 1 0 0 1 1 1 0 Dynactin p62 family Omp_AT PF11557.8 PIK58859.1 - 8.7 5.2 6.5 1.6 7.6 2.7 1.6 1 1 1 2 2 2 0 Solitary outer membrane autotransporter beta-barrel domain zf-3CxxC PF13695.6 PIK58860.1 - 3.7e-19 69.0 1.9 5.2e-19 68.6 1.9 1.2 1 0 0 1 1 1 1 Zinc-binding domain DUF3465 PF11948.8 PIK58860.1 - 0.061 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) HypA PF01155.19 PIK58860.1 - 0.062 13.3 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_9 PF13901.6 PIK58861.1 - 5.5e-32 111.4 4.9 2.5e-19 70.1 0.2 2.4 1 1 1 2 2 2 2 Putative zinc-RING and/or ribbon RUN PF02759.19 PIK58861.1 - 2.3e-10 40.5 0.2 5.6e-10 39.3 0.2 1.6 1 0 0 1 1 1 1 RUN domain zf-RRN7 PF11781.8 PIK58861.1 - 0.28 10.9 6.0 0.39 10.4 1.6 2.6 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 hSac2 PF12456.8 PIK58862.1 - 5.4e-23 80.9 0.0 8.1e-23 80.3 0.0 1.2 1 0 0 1 1 1 1 Inositol phosphatase GTP_cyclohydroI PF01227.22 PIK58863.1 - 3.2e-73 245.0 0.4 4.3e-73 244.6 0.4 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 PIK58863.1 - 0.016 15.4 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 QueF-like protein Peptidase_S64 PF08192.11 PIK58863.1 - 0.12 10.8 5.1 0.15 10.5 5.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 FAD_binding_4 PF01565.23 PIK58864.1 - 3.3e-25 88.5 0.1 4.5e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 PIK58865.1 - 1.4e-40 139.5 0.0 1.6e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain AdoHcyase_NAD PF00670.21 PIK58865.1 - 0.15 12.1 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain PH PF00169.29 PIK58866.1 - 7.1e-06 26.5 0.2 2.1e-05 25.0 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_BEACH PF14844.6 PIK58866.1 - 0.002 18.2 0.0 0.005 16.9 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH RuBisCO_small PF00101.20 PIK58866.1 - 0.081 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase, small chain SHR-BD PF06650.12 PIK58867.1 - 1.4e-55 188.6 0.0 2.4e-55 187.8 0.0 1.4 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 PIK58867.1 - 8e-28 97.4 10.0 1.1e-20 74.1 0.2 3.4 2 1 1 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal Hormone_recep PF00104.30 PIK58867.1 - 0.001 18.7 0.4 0.0019 17.8 0.4 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ATG_C PF09333.11 PIK58867.1 - 0.0032 17.8 0.0 0.012 15.9 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Ricin_B_lectin PF00652.22 PIK58867.1 - 0.0069 16.6 0.0 0.017 15.4 0.0 1.6 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Senescence PF06911.12 PIK58867.1 - 0.076 13.3 0.6 0.35 11.2 0.1 2.2 3 0 0 3 3 3 0 Senescence-associated protein VPS13_mid_rpt PF16910.5 PIK58868.1 - 2.6e-05 23.8 6.0 0.0002 20.8 0.3 4.2 4 1 0 4 4 4 1 Repeating coiled region of VPS13 UBA PF00627.31 PIK58868.1 - 0.0002 21.2 0.0 0.00042 20.2 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain VPS13_mid_rpt PF16910.5 PIK58869.1 - 6.3e-27 94.5 0.3 8e-26 90.9 0.3 2.1 1 1 0 1 1 1 1 Repeating coiled region of VPS13 CAMSAP_CC1 PF17095.5 PIK58870.1 - 0.02 14.8 0.4 0.031 14.1 0.4 1.3 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Chorein_N PF12624.7 PIK58871.1 - 4.4e-36 123.5 0.4 2.3e-35 121.2 0.0 2.0 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 PIK58871.1 - 6e-36 124.4 0.1 7.9e-36 124.0 0.1 1.2 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Scramblase PF03803.15 PIK58872.1 - 4.3e-49 166.8 0.1 1.1e-33 116.5 0.0 2.1 1 1 1 2 2 2 2 Scramblase Med1 PF10744.9 PIK58872.1 - 0.019 14.0 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 MFS_1 PF07690.16 PIK58874.1 - 6.3e-05 22.1 13.3 7.6e-05 21.8 13.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily RPE65 PF03055.15 PIK58875.1 - 4.4e-94 316.3 0.0 6.7e-68 230.0 0.0 2.1 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein WD40 PF00400.32 PIK58876.1 - 4.9e-29 100.0 1.5 1.3e-06 29.0 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat CSTF1_dimer PF16699.5 PIK58876.1 - 2.9e-22 78.2 0.1 5.1e-22 77.4 0.1 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.7 PIK58876.1 - 1.7e-15 57.1 0.1 0.018 15.4 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK58876.1 - 1.1e-06 27.9 1.3 0.4 9.6 0.1 3.2 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK58876.1 - 0.00038 20.4 0.9 0.33 10.8 0.1 3.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 PIK58876.1 - 0.0019 17.3 0.0 0.012 14.6 0.0 2.1 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 PIK58876.1 - 0.0029 16.2 0.0 0.013 14.0 0.0 2.1 3 0 0 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 PIK58876.1 - 0.0032 16.9 0.1 0.86 8.9 0.0 2.8 2 1 0 3 3 3 2 WD40-like domain TFIIIC_delta PF12657.7 PIK58876.1 - 0.063 13.2 0.2 0.16 11.9 0.1 1.7 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term TEX15 PF15326.6 PIK58876.1 - 0.13 11.9 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Testis expressed sequence 15 Ima1_N PF09779.9 PIK58877.1 - 1.1e-21 78.1 3.4 2.1e-21 77.2 3.4 1.4 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-LITAF-like PF10601.9 PIK58877.1 - 0.058 13.7 1.7 0.23 11.7 0.8 2.3 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-FPG_IleRS PF06827.14 PIK58877.1 - 1.3 8.9 5.3 13 5.8 1.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Gin PF10764.9 PIK58877.1 - 1.6 8.8 3.9 17 5.5 0.1 2.7 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin YqzM PF14141.6 PIK58877.1 - 4.6 7.4 7.5 2.4 8.3 0.5 2.5 2 0 0 2 2 2 0 YqzM-like protein EMC1_C PF07774.13 PIK58878.1 - 2.6e-71 239.7 0.0 5e-71 238.8 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 PIK58878.1 - 2.2e-08 33.6 0.1 0.006 16.5 0.0 4.1 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_2 PF13360.6 PIK58878.1 - 2.3e-07 30.7 0.5 0.013 15.1 0.0 4.3 4 1 0 4 4 4 2 PQQ-like domain RRM_1 PF00076.22 PIK58879.1 - 2e-15 56.3 0.0 3.1e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BAH PF01426.18 PIK58880.1 - 2.5e-17 62.9 0.1 4.1e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 BAH domain ELM2 PF01448.24 PIK58880.1 - 9.6e-10 39.1 1.1 2.8e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 ELM2 domain GATA PF00320.27 PIK58880.1 - 3.4e-07 29.7 3.8 7.4e-07 28.7 3.8 1.6 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-bind_7 PF15963.5 PIK58880.1 - 0.023 14.6 0.1 0.052 13.4 0.1 1.5 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.31 PIK58880.1 - 0.084 13.1 0.1 0.25 11.6 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Atrophin-1 PF03154.15 PIK58881.1 - 5.7e-25 87.8 1.4 7e-25 87.5 1.4 1.1 1 0 0 1 1 1 1 Atrophin-1 family BBS2_C PF14782.6 PIK58881.1 - 0.033 12.9 0.9 0.038 12.8 0.9 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF1682 PF07946.14 PIK58881.1 - 0.12 11.5 7.3 0.13 11.4 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Phage_Gp23 PF10669.9 PIK58881.1 - 0.19 12.1 7.1 0.24 11.7 7.1 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF3915 PF13054.6 PIK58881.1 - 2.8 7.9 4.9 4.4 7.3 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Mlf1IP PF10248.9 PIK58882.1 - 5e-20 72.2 3.5 5e-20 72.2 3.5 1.9 2 0 0 2 2 2 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein eIF-5a PF01287.20 PIK58883.1 - 1.5e-17 63.4 0.2 2.4e-17 62.8 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold NTR2 PF15458.6 PIK58883.1 - 0.0038 16.8 0.1 0.0044 16.6 0.1 1.1 1 0 0 1 1 1 1 Nineteen complex-related protein 2 EFP_N PF08207.12 PIK58883.1 - 0.017 15.2 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Pro_isomerase PF00160.21 PIK58885.1 - 1e-37 129.8 0.7 1.3e-37 129.6 0.7 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4885 PF16226.5 PIK58885.1 - 0.0019 17.3 0.0 0.0022 17.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4885) Dynein_C PF18199.1 PIK58886.1 - 0.11 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain DUF5614 PF18474.1 PIK58887.1 - 3.6e-46 157.2 0.1 6.8e-46 156.3 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5614) DUF1308 PF07000.11 PIK58887.1 - 8.3e-40 136.4 0.1 1.6e-39 135.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) KH_6 PF15985.5 PIK58887.1 - 0.035 14.5 0.1 0.09 13.1 0.1 1.8 1 0 0 1 1 1 0 KH domain PRC PF05239.16 PIK58887.1 - 0.085 13.0 0.1 0.7 10.0 0.0 2.6 3 0 0 3 3 3 0 PRC-barrel domain Tropomyosin_1 PF12718.7 PIK58887.1 - 0.87 9.7 4.3 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Tropomyosin like PspB PF06667.12 PIK58887.1 - 2.1 8.5 5.4 4.9 7.3 0.3 2.6 3 0 0 3 3 3 0 Phage shock protein B PH PF00169.29 PIK58891.1 - 4.2e-07 30.4 0.0 6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK58891.1 - 0.023 15.1 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3694 PF12473.8 PIK58892.1 - 1.3e-39 136.3 0.1 2e-38 132.5 0.0 2.7 3 0 0 3 3 3 1 Kinesin protein KIF1B PF12423.8 PIK58892.1 - 1.3e-11 44.7 0.0 4.5e-11 43.0 0.0 2.0 1 0 0 1 1 1 1 Kinesin protein 1B Kinesin PF00225.23 PIK58893.1 - 7.5e-65 219.0 0.3 1.1e-64 218.5 0.3 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 PIK58893.1 - 2.4e-10 40.9 3.7 1.8e-09 38.0 1.6 2.7 2 1 1 3 3 3 1 Kinesin-associated G-gamma PF00631.22 PIK58893.1 - 0.012 15.6 0.5 0.27 11.3 0.1 2.7 2 1 1 3 3 3 0 GGL domain Methyltr_RsmB-F PF01189.17 PIK58894.1 - 7.5e-30 104.1 0.1 1.8e-29 102.8 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 PIK58894.1 - 0.0014 18.7 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase NUC153 PF08159.12 PIK58894.1 - 0.073 12.9 0.1 1.9 8.4 0.1 2.6 2 0 0 2 2 2 0 NUC153 domain DUF778 PF05608.12 PIK58895.1 - 2.4e-32 112.9 2.0 8.2e-19 68.7 0.8 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF778) Arc_trans_TRASH PF08394.10 PIK58895.1 - 0.051 13.9 0.7 0.093 13.1 0.7 1.4 1 0 0 1 1 1 0 Archaeal TRASH domain Sulfatase PF00884.23 PIK58896.1 - 1.6e-43 149.3 0.2 2e-43 148.9 0.2 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 PIK58897.1 - 0.026 15.3 0.0 0.067 13.9 0.0 1.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 PIK58897.1 - 0.045 13.7 0.1 0.97 9.4 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function LBP_BPI_CETP PF01273.25 PIK58898.1 - 0.028 14.0 0.5 0.04 13.5 0.5 1.2 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain TNFR_c6 PF00020.18 PIK58899.1 - 0.00038 20.8 14.7 0.00038 20.8 14.7 2.2 2 0 0 2 2 2 1 TNFR/NGFR cysteine-rich region zf-C3HC4_3 PF13920.6 PIK58899.1 - 2.1 8.2 21.1 5.5 6.9 16.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FAM181 PF15238.6 PIK58900.1 - 0.024 14.5 3.7 0.044 13.6 3.1 1.9 1 1 0 1 1 1 0 FAM181 Phage_integrase PF00589.22 PIK58900.1 - 0.035 13.9 0.0 0.077 12.8 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family SAM_1 PF00536.30 PIK58901.1 - 1.2e-27 96.2 6.0 9.8e-15 54.8 0.3 3.5 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK58901.1 - 8.8e-27 93.0 1.1 1e-09 38.3 0.0 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_KSR1 PF13543.6 PIK58901.1 - 0.19 11.9 0.9 4.5 7.4 0.0 2.7 1 1 1 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 KCNQC3-Ank-G_bd PF11956.8 PIK58902.1 - 0.019 15.3 2.7 0.095 13.0 2.7 2.2 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 TPR_MLP1_2 PF07926.12 PIK58902.1 - 0.043 13.9 65.9 0.13 12.4 19.9 3.7 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein COX6C PF02937.15 PIK58902.1 - 0.06 13.5 0.4 20 5.4 0.1 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc TGT_C1 PF14809.6 PIK58902.1 - 0.77 10.1 6.3 15 6.0 0.5 3.0 3 0 0 3 3 3 0 C1 domain of tRNA-guanine transglycosylase dimerisation SLATT_6 PF18169.1 PIK58902.1 - 1.3 8.5 13.6 1.4 8.5 1.1 2.8 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 6 DUF4686 PF15742.5 PIK58902.1 - 1.5 7.8 62.5 3.1 6.8 36.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) RRP7 PF12923.7 PIK58902.1 - 1.6 8.9 36.4 0.28 11.3 6.6 4.3 4 0 0 4 4 4 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Spc7 PF08317.11 PIK58902.1 - 2.2 7.1 59.1 0.14 11.0 11.2 3.5 2 1 1 3 3 3 0 Spc7 kinetochore protein DsrC PF04358.13 PIK58902.1 - 2.7 8.5 19.2 2 9.0 1.0 4.5 2 2 2 4 4 4 0 DsrC like protein WXG100 PF06013.12 PIK58902.1 - 4.7 7.5 21.2 3.6 7.9 2.2 4.9 4 2 0 4 4 4 0 Proteins of 100 residues with WXG TFIID_30kDa PF03540.13 PIK58903.1 - 2.7e-25 88.1 0.0 3.9e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 PIK58903.1 - 0.00072 19.5 0.0 0.013 15.5 0.0 2.0 1 1 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 PIK58903.1 - 0.053 13.8 0.0 3.8 7.9 0.0 2.1 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 PIK58903.1 - 0.064 13.4 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) HTH_42 PF06224.12 PIK58903.1 - 0.066 12.7 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF1499 PF07386.11 PIK58904.1 - 0.0016 18.9 0.0 0.0021 18.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1499) HYR PF02494.16 PIK58905.1 - 1.2e-51 173.0 38.1 3.7e-17 62.4 0.3 5.2 5 0 0 5 5 5 5 HYR domain DUF859 PF05895.12 PIK58905.1 - 0.013 14.0 0.0 32 2.8 0.0 3.8 4 0 0 4 4 4 0 Siphovirus protein of unknown function (DUF859) Toprim_C_rpt PF13368.6 PIK58905.1 - 0.039 13.9 0.0 42 4.3 0.0 3.6 4 0 0 4 4 4 0 Topoisomerase C-terminal repeat HYR PF02494.16 PIK58906.1 - 2.2e-14 53.5 5.1 3.4e-07 30.5 0.3 2.1 2 0 0 2 2 2 2 HYR domain EGF_3 PF12947.7 PIK58906.1 - 0.27 11.5 4.2 3.3 8.0 1.0 2.7 2 0 0 2 2 2 0 EGF domain HYR PF02494.16 PIK58907.1 - 1.6e-61 204.6 30.0 2.8e-14 53.2 0.7 6.1 6 0 0 6 6 6 6 HYR domain fn3 PF00041.21 PIK58907.1 - 2.8e-06 27.6 5.6 1.4 9.3 0.0 4.7 4 0 0 4 4 4 4 Fibronectin type III domain HYR PF02494.16 PIK58908.1 - 6.9e-99 324.3 57.8 4.2e-16 59.0 3.5 7.3 7 1 0 7 7 7 7 HYR domain DUF5011 PF16403.5 PIK58908.1 - 0.0002 21.4 0.4 0.35 11.0 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF5011) Reeler PF02014.16 PIK58908.1 - 0.049 14.4 6.5 44 4.8 0.0 5.1 4 1 1 5 5 5 0 Reeler domain VP4_2 PF08935.10 PIK58908.1 - 0.21 12.2 0.8 3 8.5 0.2 2.8 2 0 0 2 2 2 0 Viral protein VP4 subunit YjzC PF14168.6 PIK58908.1 - 0.23 11.8 0.9 3.5 8.1 0.0 2.5 2 0 0 2 2 2 0 YjzC-like protein HYR PF02494.16 PIK58909.1 - 0 1005.3 179.8 3.1e-18 65.9 1.6 22.9 22 1 1 23 23 23 22 HYR domain DUF5011 PF16403.5 PIK58909.1 - 6.6e-12 45.4 7.4 3.2 8.0 0.0 11.7 15 0 0 15 15 15 3 Domain of unknown function (DUF5011) EGF PF00008.27 PIK58909.1 - 5.1e-08 33.1 4.6 5.8e-07 29.7 4.6 3.1 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 PIK58909.1 - 0.0019 18.8 7.2 0.025 15.2 5.3 4.4 2 0 0 2 2 2 1 Human growth factor-like EGF Big_8 PF17961.1 PIK58909.1 - 0.044 13.9 27.6 17 5.6 0.0 10.1 11 1 1 12 12 12 0 Bacterial Ig domain EGF_2 PF07974.13 PIK58909.1 - 0.43 11.0 8.2 1.9 8.9 8.2 2.3 1 0 0 1 1 1 0 EGF-like domain HYR PF02494.16 PIK58910.1 - 2.7e-87 287.2 47.9 4.7e-15 55.7 0.1 7.3 7 0 0 7 7 7 7 HYR domain Big_3_3 PF13750.6 PIK58910.1 - 9.3e-09 35.1 5.4 1.3 8.6 0.0 6.4 5 1 1 6 6 6 4 Bacterial Ig-like domain (group 3) HYR PF02494.16 PIK58911.1 - 1.4e-60 201.6 54.2 1.3e-12 47.9 4.8 7.3 7 0 0 7 7 7 7 HYR domain MRP-S22 PF10245.9 PIK58912.1 - 3e-102 341.5 0.6 3.9e-102 341.1 0.6 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 Fer2_3 PF13085.6 PIK58913.1 - 8.7e-34 115.8 0.1 1.7e-33 114.9 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 PIK58913.1 - 1.5e-09 38.2 6.6 1.5e-09 38.2 6.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 PIK58913.1 - 4.4e-08 33.4 8.0 4.4e-08 33.4 8.0 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 PIK58913.1 - 3.1e-07 30.4 3.8 3.1e-07 30.4 3.8 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 PIK58913.1 - 0.005 17.4 6.6 0.005 17.4 6.6 2.7 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 PIK58913.1 - 0.0052 16.7 0.3 0.0052 16.7 0.3 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.6 PIK58913.1 - 0.0073 16.5 0.5 0.34 11.1 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 PIK58913.1 - 0.11 13.4 8.3 1.3 10.0 1.2 3.0 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 PIK58913.1 - 0.13 12.4 13.7 0.042 14.0 8.2 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Alk_phosphatase PF00245.20 PIK58914.1 - 9.7e-83 278.4 0.0 9.2e-67 225.8 0.0 2.0 1 1 1 2 2 2 2 Alkaline phosphatase Alk_phosphatase PF00245.20 PIK58915.1 - 1.4e-11 44.1 0.0 1.7e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase PT PF04886.12 PIK58915.1 - 3e-06 26.7 1.0 2.4 7.8 0.0 5.4 4 2 1 5 5 5 3 PT repeat Keratin_B2 PF01500.17 PIK58915.1 - 1.1 9.2 9.0 3 7.8 1.3 3.2 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein RRM_1 PF00076.22 PIK58916.1 - 3.4e-27 94.0 0.2 1.3e-12 47.4 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TDP43_N PF18694.1 PIK58916.1 - 4e-15 55.4 0.0 7.4e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_7 PF16367.5 PIK58916.1 - 7e-07 29.3 0.3 0.12 12.5 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 PIK58916.1 - 0.00011 22.2 0.1 0.029 14.4 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 PIK58916.1 - 0.001 19.0 0.1 0.32 11.0 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 PIK58916.1 - 0.0076 16.2 0.0 0.46 10.5 0.0 2.3 2 0 0 2 2 2 1 RL domain Ish1 PF10281.9 PIK58916.1 - 0.027 14.8 0.2 5.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein RRM_occluded PF16842.5 PIK58916.1 - 0.035 14.0 0.0 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif OB_RNB PF08206.11 PIK58916.1 - 0.06 13.0 0.3 4.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Pkinase_Tyr PF07714.17 PIK58921.1 - 1e-05 25.0 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ig PF00047.25 PIK58921.1 - 0.0001 22.4 0.1 0.84 9.8 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK58921.1 - 0.013 15.5 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain DUF1622 PF07784.11 PIK58921.1 - 0.046 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1622) ETRAMP PF09716.10 PIK58921.1 - 0.056 13.5 0.9 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) NLRC4_HD2 PF17776.1 PIK58922.1 - 0.028 15.0 1.1 0.21 12.1 1.1 2.6 1 1 0 1 1 1 0 NLRC4 helical domain HD2 DUF2796 PF10986.8 PIK58922.1 - 0.12 12.3 1.1 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Death PF00531.22 PIK58923.1 - 6.4e-10 39.1 0.2 1.1e-09 38.3 0.2 1.3 1 0 0 1 1 1 1 Death domain TILa PF12714.7 PIK58924.1 - 1.2e-15 57.1 51.8 1.7e-06 27.9 5.6 5.2 3 1 2 5 5 5 3 TILa domain EGF_3 PF12947.7 PIK58924.1 - 6.8e-12 45.4 69.5 6.4e-05 23.1 12.3 6.8 5 2 2 7 7 7 3 EGF domain Fibrinogen_C PF00147.18 PIK58924.1 - 7.3e-09 35.7 0.0 4.5e-06 26.6 0.0 2.7 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK58924.1 - 0.024 14.9 12.1 0.024 14.9 12.1 6.2 2 1 4 6 6 6 0 Trypsin Inhibitor like cysteine rich domain Caprin-1_C PF12287.8 PIK58924.1 - 0.026 14.7 5.8 0.77 9.8 0.4 2.8 1 1 1 3 3 3 0 Cytoplasmic activation/proliferation-associated protein-1 C term EGF_2 PF07974.13 PIK58924.1 - 0.043 14.2 10.3 0.043 14.2 10.3 7.2 6 3 2 8 8 8 0 EGF-like domain Fibrinogen_C PF00147.18 PIK58925.1 - 5.8e-16 59.0 0.6 6.7e-07 29.3 0.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK58925.1 - 0.00036 20.7 11.8 0.00093 19.3 10.0 2.6 1 1 1 2 2 2 1 EGF domain TILa PF12714.7 PIK58925.1 - 0.00059 19.7 1.8 0.00059 19.7 1.8 2.2 3 0 0 3 3 3 1 TILa domain RVT_1 PF00078.27 PIK58926.1 - 7.1e-19 68.2 0.0 1.3e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MLVIN_C PF18697.1 PIK58926.1 - 0.088 12.9 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Integrase_H2C2 PF17921.1 PIK58927.1 - 8.2e-20 70.7 1.1 1.4e-19 69.9 1.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK58927.1 - 1e-19 70.8 0.0 5.5e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK58927.1 - 2.7e-05 24.3 0.2 5.6e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK58927.1 - 0.00053 19.7 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Fimbrillin_C PF15495.6 PIK58927.1 - 0.13 12.7 0.2 0.51 10.8 0.0 1.9 2 0 0 2 2 2 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal RVT_1 PF00078.27 PIK58928.1 - 3.5e-06 26.7 0.0 4.2e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAM150 PF15129.6 PIK58929.1 - 0.52 10.5 5.1 42 4.3 0.1 3.3 1 1 2 3 3 3 0 FAM150 family DUF1736 PF08409.11 PIK58929.1 - 1.2 9.2 10.5 1.1e+02 2.9 0.1 5.3 1 1 5 6 6 6 0 Domain of unknown function (DUF1736) Kelch_3 PF13415.6 PIK58930.1 - 2.1e-44 149.0 10.5 4.1e-08 33.3 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK58930.1 - 8.1e-39 131.4 9.8 7.4e-07 29.1 0.0 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 PIK58930.1 - 3.1e-37 125.9 13.0 2.8e-06 26.8 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 PIK58930.1 - 4.8e-36 121.9 10.0 1.6e-07 31.4 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.6 PIK58930.1 - 3.7e-35 119.4 6.6 2.6e-06 27.3 0.2 6.6 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 PIK58930.1 - 1.2e-25 89.8 0.1 2.7e-11 43.7 0.0 3.0 2 1 1 3 3 3 2 BTB/POZ domain Kelch_2 PF07646.15 PIK58930.1 - 2.6e-22 77.9 10.2 1.9e-06 27.6 0.0 6.7 6 0 0 6 6 6 6 Kelch motif RAG2 PF03089.14 PIK58930.1 - 0.00091 18.3 0.0 0.092 11.7 0.0 3.0 3 0 0 3 3 3 1 Recombination activating protein 2 Pkinase_Tyr PF07714.17 PIK58931.1 - 1e-23 83.9 0.0 1.3e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58931.1 - 1.2e-23 83.9 0.0 1.5e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Peptidase_M10 PF00413.24 PIK58932.1 - 6.5e-54 182.0 0.1 1e-53 181.4 0.1 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK58932.1 - 2e-43 146.1 16.5 1.1e-15 57.3 1.9 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 PIK58932.1 - 0.00017 21.7 0.7 0.00035 20.7 0.7 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 PIK58932.1 - 0.0046 16.6 0.3 3 7.4 0.0 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 PIK58932.1 - 0.018 15.6 0.1 0.03 14.8 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK58932.1 - 0.037 14.2 0.1 0.062 13.5 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 PIK58932.1 - 0.11 12.1 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK58932.1 - 0.19 10.9 0.2 0.31 10.2 0.2 1.3 1 0 0 1 1 1 0 Met-zincin GST_C PF00043.25 PIK58933.1 - 1.9e-08 34.4 0.5 6.7e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK58933.1 - 1e-07 31.9 0.0 2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK58933.1 - 6.5e-07 29.6 0.0 1.6e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK58933.1 - 1.2e-06 28.8 0.0 2.8e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK58933.1 - 3.2e-06 27.3 1.1 5.5e-06 26.5 0.0 2.0 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK58933.1 - 2.3e-05 24.6 0.1 8.6e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK58933.1 - 0.0011 19.6 0.0 0.0041 17.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 PIK58933.1 - 0.0014 18.4 0.0 0.005 16.6 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 PIK58933.1 - 0.019 15.3 0.0 0.04 14.2 0.0 1.6 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein SAM_KSR1 PF13543.6 PIK58933.1 - 0.072 13.2 0.2 4.1 7.6 0.0 2.3 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 Peptidase_M14 PF00246.24 PIK58934.1 - 1.4e-57 195.8 0.0 1.6e-57 195.5 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK58934.1 - 3e-16 59.6 0.3 5.6e-16 58.7 0.3 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide B5 PF03484.15 PIK58934.1 - 0.05 13.9 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase B5 domain An_peroxidase PF03098.15 PIK58936.1 - 2.1e-70 237.8 0.0 2.6e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase CNDH2_C PF16858.5 PIK58937.1 - 0.07 13.0 10.1 0.083 12.7 10.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF3527 PF12043.8 PIK58937.1 - 1.9 8.0 8.6 2.5 7.6 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) SOBP PF15279.6 PIK58937.1 - 4.5 7.8 15.6 6.8 7.2 15.6 1.3 1 1 0 1 1 1 0 Sine oculis-binding protein PhoLip_ATPase_C PF16212.5 PIK58938.1 - 1.8e-46 158.9 29.3 1.8e-46 158.9 29.3 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 PIK58938.1 - 1.3e-12 48.4 0.8 6.1e-08 33.2 0.3 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK58938.1 - 2.4e-12 46.8 0.0 1.5e-11 44.2 0.0 2.3 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 PIK58938.1 - 5.2e-11 42.4 0.0 1.3e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 PIK58938.1 - 1e-05 25.4 0.3 0.0058 16.4 0.0 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 PIK58938.1 - 0.075 13.4 0.0 21 5.5 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase CC2-LZ PF16516.5 PIK58938.1 - 0.081 13.3 0.6 0.23 11.9 0.6 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HAD_2 PF13419.6 PIK58938.1 - 0.15 12.1 0.2 0.53 10.4 0.1 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF4404 PF14357.6 PIK58938.1 - 0.21 12.3 6.6 0.16 12.6 4.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Peptidase_C54 PF03416.19 PIK58939.1 - 1.2e-37 129.9 0.2 1.3e-37 129.7 0.2 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C54 PF03416.19 PIK58940.1 - 2.2e-43 148.7 0.0 2.5e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Astacin PF01400.24 PIK58941.1 - 4.8e-56 189.4 0.4 8.8e-56 188.6 0.4 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 PIK58941.1 - 7.7e-20 71.3 0.0 1.8e-09 37.9 0.0 2.5 2 1 1 3 3 3 2 CUB domain FXa_inhibition PF14670.6 PIK58941.1 - 1e-06 28.9 8.4 2.6e-06 27.6 8.4 1.8 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK58941.1 - 0.01 16.0 8.2 0.025 14.8 8.2 1.7 1 0 0 1 1 1 0 Calcium-binding EGF domain HCV_env PF01539.17 PIK58941.1 - 0.029 14.1 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 Reprolysin_4 PF13583.6 PIK58941.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like EGF_3 PF12947.7 PIK58941.1 - 0.13 12.5 6.9 0.33 11.2 6.9 1.8 1 0 0 1 1 1 0 EGF domain LRR_8 PF13855.6 PIK58942.1 - 8.8e-05 22.2 10.4 0.005 16.6 0.3 4.6 3 1 1 4 4 4 3 Leucine rich repeat TMEM154 PF15102.6 PIK58942.1 - 0.71 9.8 2.8 0.33 10.8 0.1 1.8 2 0 0 2 2 2 0 TMEM154 protein family LRR_4 PF12799.7 PIK58942.1 - 4.3 7.9 16.8 3.7 8.1 0.0 5.2 4 2 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK58943.1 - 0.00011 21.9 3.9 0.22 11.3 0.0 4.3 6 0 0 6 6 6 3 Leucine rich repeat Neur_chan_memb PF02932.16 PIK58944.1 - 1.7e-18 67.6 0.9 2e-18 67.3 0.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 PIK58945.1 - 2.6e-20 73.5 2.9 3.2e-20 73.2 2.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CNOT11 PF10155.9 PIK58945.1 - 0.019 15.2 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 Neur_chan_LBD PF02931.23 PIK58946.1 - 2.6e-34 118.6 0.2 3.6e-34 118.1 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK58946.1 - 6.5e-17 62.4 8.6 6.3e-15 55.9 3.7 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region FTH PF01827.27 PIK58946.1 - 0.037 13.8 0.2 0.075 12.8 0.2 1.5 1 0 0 1 1 1 0 FTH domain Neur_chan_memb PF02932.16 PIK58947.1 - 1.2e-16 61.5 0.0 1.5e-16 61.2 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK58947.1 - 0.014 14.8 0.1 0.021 14.3 0.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain Ldl_recept_a PF00057.18 PIK58948.1 - 1.4e-41 140.4 81.6 1.4e-10 41.2 12.9 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK58948.1 - 2.2e-15 56.9 0.1 4.6e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 CUB domain Gal-3-0_sulfotr PF06990.11 PIK58949.1 - 1.7e-38 132.6 0.7 2e-38 132.3 0.7 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Phage_Mu_Gp45 PF06890.12 PIK58949.1 - 0.1 12.3 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gp45 protein Aldedh PF00171.22 PIK58950.1 - 2.5e-182 606.5 0.0 1.6e-154 514.9 0.0 3.0 2 1 1 3 3 3 3 Aldehyde dehydrogenase family DUF1487 PF07368.11 PIK58950.1 - 0.00046 19.7 0.4 0.0069 15.9 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF1487) GCFC PF07842.12 PIK58951.1 - 5.3e-87 291.9 14.6 5.3e-87 291.9 14.6 1.7 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 PIK58951.1 - 1.2e-14 53.9 2.7 2.7e-14 52.8 2.7 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK58951.1 - 9.5e-06 25.6 1.2 3.8e-05 23.7 1.2 2.1 1 0 0 1 1 1 1 G-patch domain DUF5099 PF17025.5 PIK58951.1 - 0.058 13.8 1.1 0.11 12.9 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) 7tm_2 PF00002.24 PIK58952.1 - 1.6e-22 80.0 17.5 2.6e-22 79.3 17.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK58952.1 - 0.038 14.4 12.8 0.16 12.4 12.8 2.1 1 0 0 1 1 1 0 Somatomedin B domain IFT57 PF10498.9 PIK58953.1 - 0.036 13.0 2.6 0.062 12.3 2.6 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.10 PIK58953.1 - 0.06 13.5 0.8 0.11 12.7 0.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1351 PF07083.11 PIK58953.1 - 0.06 13.1 4.8 0.33 10.7 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) Terminase_6C PF17289.2 PIK58953.1 - 0.1 12.7 0.6 0.54 10.3 0.2 2.3 2 1 0 2 2 2 0 Terminase RNaseH-like domain Prefoldin PF02996.17 PIK58953.1 - 0.14 12.1 2.0 0.25 11.3 1.4 1.8 1 1 0 1 1 1 0 Prefoldin subunit DUF2913 PF11140.8 PIK58953.1 - 0.24 11.1 3.3 1.6 8.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) RVT_1 PF00078.27 PIK58954.1 - 3.2e-52 177.3 0.0 3.9e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ABC_transp_aux PF09822.9 PIK58954.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 ABC-type uncharacterized transport system TPR_1 PF00515.28 PIK58955.1 - 2.9e-35 118.7 12.9 1.4e-08 34.2 0.3 10.4 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 PIK58955.1 - 2.4e-33 111.6 16.5 2.4e-06 27.2 0.4 9.8 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_11 PF13414.6 PIK58955.1 - 1.2e-26 92.1 17.3 5.8e-09 35.5 0.1 9.3 7 3 3 10 10 10 5 TPR repeat TPR_8 PF13181.6 PIK58955.1 - 1.8e-24 83.8 11.6 0.0025 17.9 0.1 9.2 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 PIK58955.1 - 1.5e-23 81.4 8.0 0.019 15.3 0.0 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 PIK58955.1 - 1.5e-23 82.9 26.6 0.00021 21.5 0.6 7.4 3 3 4 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 PIK58955.1 - 1.2e-17 64.2 8.3 0.0026 18.4 0.2 6.2 5 2 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 PIK58955.1 - 1.1e-16 59.6 7.7 0.015 15.3 0.1 7.9 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 PIK58955.1 - 1.3e-14 54.4 9.6 0.00071 20.0 0.4 6.3 2 1 7 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 PIK58955.1 - 6.1e-14 51.5 6.8 0.24 12.3 0.1 9.0 2 1 8 10 10 10 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK58955.1 - 1.4e-13 50.2 25.3 0.012 15.4 0.2 9.4 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.6 PIK58955.1 - 5.3e-07 29.9 7.5 0.31 11.8 0.1 7.3 9 0 0 9 9 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK58955.1 - 2.2e-06 27.8 8.9 0.00038 20.6 0.5 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK58955.1 - 1.4e-05 25.1 3.0 3.3 7.9 0.1 5.0 2 2 3 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 PIK58955.1 - 0.0022 18.4 0.8 2.5 9.0 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 PIK58955.1 - 0.0041 17.1 1.4 8.6 6.5 0.1 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat FAT PF02259.23 PIK58955.1 - 0.0073 15.6 2.5 0.039 13.2 0.2 2.2 2 0 0 2 2 2 1 FAT domain ANAPC5 PF12862.7 PIK58955.1 - 0.0085 16.1 8.3 2.4 8.3 0.1 4.7 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 5 EST1_DNA_bind PF10373.9 PIK58955.1 - 0.031 13.8 1.7 0.72 9.3 0.2 2.9 3 0 0 3 3 3 0 Est1 DNA/RNA binding domain Mannosyl_trans4 PF15971.5 PIK58955.1 - 0.066 13.1 2.4 0.14 12.0 2.4 1.6 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase TPR_21 PF09976.9 PIK58955.1 - 0.24 11.1 4.9 0.4 10.4 1.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain MIT PF04212.18 PIK58955.1 - 0.39 10.8 4.4 17 5.6 0.1 3.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 PIK58955.1 - 0.61 9.5 4.4 1 8.7 0.3 2.9 4 0 0 4 4 4 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.6 PIK58955.1 - 0.77 9.9 3.3 2.6 8.2 0.3 3.4 5 0 0 5 5 2 0 Fis1 C-terminal tetratricopeptide repeat SSF PF00474.17 PIK58956.1 - 1.2e-12 47.5 7.1 1.2e-12 47.5 7.1 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family Ig_3 PF13927.6 PIK58957.1 - 7.5e-09 36.1 4.2 1.2e-05 25.8 0.4 3.1 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK58957.1 - 1.6e-05 25.2 8.5 0.34 11.3 3.3 3.9 2 2 1 3 3 3 3 Immunoglobulin domain I-set PF07679.16 PIK58957.1 - 5.1e-05 23.3 0.6 0.0013 18.7 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK58957.1 - 6.4e-05 23.1 3.0 0.0022 18.1 0.2 3.1 2 2 1 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK58957.1 - 0.00032 20.9 3.4 0.016 15.4 0.4 3.0 2 2 0 2 2 2 2 Immunoglobulin V-set domain C1-set PF07654.15 PIK58957.1 - 0.068 13.6 6.2 0.31 11.4 0.3 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK58958.1 - 9.4e-06 26.1 0.2 8.5e-05 23.1 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK58958.1 - 9.9e-05 22.5 0.6 0.0017 18.5 0.0 2.8 1 1 2 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK58958.1 - 0.00067 19.7 0.2 0.0036 17.3 0.0 2.1 1 1 1 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK58958.1 - 0.0028 17.8 0.5 0.012 15.8 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK58958.1 - 0.016 15.6 1.0 0.28 11.6 0.2 2.8 2 1 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK58959.1 - 3.3e-28 98.7 0.1 8.4e-28 97.3 0.1 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58959.1 - 1.4e-09 37.8 0.0 2.9e-09 36.7 0.0 1.5 1 1 1 2 2 2 1 Protein kinase domain GlutR_dimer PF00745.20 PIK58959.1 - 0.013 15.9 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain HSM3_N PF18795.1 PIK58959.1 - 0.016 14.6 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Pkinase_Tyr PF07714.17 PIK58960.1 - 1.2e-11 44.4 0.0 1.5e-08 34.2 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK58960.1 - 2e-05 24.1 0.0 3.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58961.1 - 5.5e-31 107.8 0.0 2.2e-26 92.7 0.3 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK58961.1 - 1.2e-10 41.2 0.0 1.6e-09 37.5 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain GlutR_dimer PF00745.20 PIK58961.1 - 0.024 15.1 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain HSM3_N PF18795.1 PIK58961.1 - 0.039 13.4 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Pkinase_Tyr PF07714.17 PIK58962.1 - 2e-26 92.8 0.0 2.6e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58962.1 - 4.6e-14 52.4 0.0 5.7e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58963.1 - 2.3e-33 115.6 0.0 2.8e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58963.1 - 5.7e-19 68.5 0.0 7.5e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF2083 PF09856.9 PIK58963.1 - 0.074 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) Pkinase_Tyr PF07714.17 PIK58964.1 - 3.3e-31 108.5 0.1 5.5e-27 94.7 0.3 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK58964.1 - 1.9e-11 43.8 0.0 2e-10 40.5 0.0 1.9 1 1 1 2 2 2 2 Protein kinase domain GlutR_dimer PF00745.20 PIK58964.1 - 0.018 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain HSM3_N PF18795.1 PIK58964.1 - 0.025 14.0 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Pkinase_Tyr PF07714.17 PIK58965.1 - 4e-40 137.7 0.0 4.6e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58965.1 - 1.4e-17 63.9 0.0 1.8e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58966.1 - 2.8e-34 118.6 0.0 4.7e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK58966.1 - 1.7e-17 63.6 0.0 3.3e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain ig PF00047.25 PIK58966.1 - 1.2e-05 25.4 0.3 0.0045 17.1 0.1 2.9 2 1 1 3 3 3 2 Immunoglobulin domain TMEM154 PF15102.6 PIK58966.1 - 0.0026 17.7 2.7 0.0055 16.6 2.7 1.6 1 1 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 PIK58966.1 - 0.0039 17.7 1.5 0.95 10.1 0.2 2.8 2 0 0 2 2 2 2 Immunoglobulin domain OAS1_C PF10421.9 PIK58967.1 - 2.3e-09 37.0 0.0 3.1e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus OAS1_C PF10421.9 PIK58968.1 - 4.5e-12 45.8 0.0 7.5e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus SMODS PF18144.1 PIK58968.1 - 1.9e-08 34.6 0.0 3.6e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 PIK58968.1 - 0.0016 18.7 0.0 0.0037 17.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain OAS1_C PF10421.9 PIK58969.1 - 1.5e-12 47.4 0.0 2.2e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Roc PF08477.13 PIK58970.1 - 0.035 14.3 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ZU5 PF00791.20 PIK58971.1 - 1.9e-24 85.9 0.0 4.6e-24 84.6 0.0 1.7 2 0 0 2 2 2 1 ZU5 domain TUDOR PF00567.24 PIK58972.1 - 9.2e-23 80.6 0.0 1.3e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 PIK58972.1 - 5.8e-13 48.5 0.0 1.1e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 PIK58972.1 - 0.006 16.4 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 PIK58972.1 - 0.024 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 KH domain Pkinase PF00069.25 PIK58973.1 - 1.2e-33 116.7 2.6 1.3e-18 67.4 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58973.1 - 7.8e-23 81.1 1.6 8.1e-12 45.0 0.8 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase DUF2087 PF09860.9 PIK58973.1 - 0.078 13.1 0.2 0.13 12.4 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) DUF3543 PF12063.8 PIK58975.1 - 8.4e-09 35.2 0.1 1.1e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) MIOX PF05153.15 PIK58976.1 - 2e-124 414.1 5.5 2.5e-124 413.8 5.5 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase CUB PF00431.20 PIK58977.1 - 2e-08 34.5 0.0 1.5e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 CUB domain SSF PF00474.17 PIK58978.1 - 9.9e-119 396.8 20.0 1.3e-118 396.4 20.0 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Beta-APP PF03494.13 PIK58978.1 - 0.022 14.6 0.5 0.076 12.9 0.5 1.9 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) WWE PF02825.20 PIK58979.1 - 2e-34 118.0 0.1 3.3e-17 62.8 0.0 2.6 2 0 0 2 2 2 2 WWE domain DUF4129 PF13559.6 PIK58979.1 - 0.012 15.9 0.5 0.063 13.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) DTC PF18102.1 PIK58980.1 - 1.3e-49 167.8 0.0 1.5e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Deltex C-terminal domain Vps53_N PF04100.12 PIK58981.1 - 8.9e-94 314.6 1.7 2.5e-93 313.1 0.3 2.0 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF4413 PF14372.6 PIK58981.1 - 0.15 12.5 0.2 1.3 9.4 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) DUF4006 PF13179.6 PIK58982.1 - 0.17 11.8 1.0 0.25 11.3 1.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Acyl-CoA_dh_1 PF00441.24 PIK58983.1 - 4.1e-22 79.0 0.2 7e-22 78.2 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK58983.1 - 2.8e-16 59.5 0.0 5e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK58983.1 - 1e-06 29.0 0.0 2.4e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 PIK58983.1 - 0.026 14.4 0.1 0.061 13.3 0.0 1.7 1 1 0 1 1 1 0 Adaptive response protein AidB N-terminal domain Septin PF00735.18 PIK58984.1 - 5.3e-129 429.5 0.4 6.1e-129 429.3 0.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 PIK58984.1 - 3.3e-08 33.6 0.0 7.5e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK58984.1 - 2.3e-06 27.3 0.6 0.021 14.3 0.1 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK58984.1 - 3.2e-06 27.1 1.2 0.00089 19.2 0.4 2.5 2 1 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 PIK58984.1 - 7.7e-05 22.1 0.0 0.00023 20.5 0.0 1.9 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 PIK58984.1 - 0.00035 20.7 3.2 0.12 12.5 0.0 3.2 3 1 1 4 4 4 2 Dynamin family Ras PF00071.22 PIK58984.1 - 0.00043 19.9 0.2 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 Ras family AAA_15 PF13175.6 PIK58984.1 - 0.0019 18.0 0.0 0.0037 17.0 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 PIK58984.1 - 0.0024 18.1 0.0 0.0048 17.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 PIK58984.1 - 0.0031 17.8 0.0 0.0096 16.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 PIK58984.1 - 0.0097 15.3 0.7 0.11 11.8 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 PIK58984.1 - 0.012 16.1 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 PIK58984.1 - 0.013 15.9 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 PIK58984.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 PIK58984.1 - 0.029 13.9 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IIGP PF05049.13 PIK58984.1 - 0.063 12.3 0.5 0.46 9.5 0.0 2.3 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) AAA_23 PF13476.6 PIK58984.1 - 0.069 13.6 0.5 0.16 12.4 0.5 1.6 1 1 0 1 1 1 0 AAA domain 2-oxogl_dehyd_N PF16078.5 PIK58984.1 - 0.12 12.0 0.3 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus AMP-binding PF00501.28 PIK58985.1 - 4.5e-66 223.2 0.0 5.7e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK58985.1 - 0.00012 23.0 0.0 0.00026 21.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TMEM219 PF14940.6 PIK58986.1 - 4.3e-38 131.2 1.4 4.9e-38 131.0 1.4 1.0 1 0 0 1 1 1 1 Transmembrane 219 Morc6_S5 PF17942.1 PIK58987.1 - 5.4e-19 68.6 3.9 4.1e-13 49.6 0.3 2.5 2 0 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like zf-CW PF07496.15 PIK58987.1 - 2.8e-13 49.6 1.0 6.5e-13 48.5 1.0 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger Mod_r PF07200.13 PIK58988.1 - 0.13 12.4 8.1 0.14 12.2 2.5 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4710 PF15828.5 PIK58988.1 - 0.19 11.9 4.9 8.3 6.6 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Ax_dynein_light PF10211.9 PIK58988.1 - 3.5 7.5 11.7 3.2 7.7 0.3 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain Glyco_transf_10 PF00852.19 PIK58989.1 - 2.2e-49 167.5 0.1 3.8e-49 166.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK58989.1 - 2.7e-05 24.6 0.0 6.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal zf-NOSIP PF15906.5 PIK58990.1 - 0.00064 19.8 0.0 0.00077 19.6 0.0 1.1 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 PIK58990.1 - 0.0074 16.1 0.1 0.0087 15.9 0.1 1.4 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Pro_isomerase PF00160.21 PIK58991.1 - 4.8e-52 176.4 0.1 1.1e-51 175.3 0.1 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 PIK58991.1 - 9.7e-06 25.1 1.6 2.3e-05 23.9 0.2 1.9 2 0 0 2 2 2 1 Rtf2 RING-finger SUI1 PF01253.22 PIK58992.1 - 2.8e-19 69.4 0.4 5.8e-19 68.4 0.4 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pyocin_S PF06958.12 PIK58992.1 - 0.09 13.3 0.3 0.13 12.8 0.3 1.2 1 0 0 1 1 1 0 S-type Pyocin AMPKBI PF04739.15 PIK58992.1 - 0.11 12.8 0.9 0.19 12.0 0.9 1.4 1 0 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interaction domain Cthe_2159 PF14262.6 PIK58993.1 - 0.0031 16.9 1.6 0.042 13.2 1.6 1.9 1 1 1 2 2 2 2 Carbohydrate-binding domain-containing protein Cthe_2159 Chloroa_b-bind PF00504.21 PIK58993.1 - 0.055 14.0 3.7 28 5.2 0.8 4.8 1 1 2 3 3 3 0 Chlorophyll A-B binding protein FTP PF07504.13 PIK58993.1 - 1.3 8.9 11.1 17 5.4 0.2 5.1 2 2 4 6 6 6 0 Fungalysin/Thermolysin Propeptide Motif SARA PF11409.8 PIK58994.1 - 2.1 8.6 5.9 77 3.6 0.1 3.7 4 0 0 4 4 4 0 Smad anchor for receptor activation (SARA) Doppel PF11466.8 PIK58994.1 - 9.8 5.9 6.7 78 3.1 0.1 3.2 3 0 0 3 3 3 0 Prion-like protein Doppel Pkinase PF00069.25 PIK58995.1 - 4.3e-73 245.9 0.0 1.1e-72 244.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK58995.1 - 7.3e-32 110.7 0.0 1.2e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 PIK58995.1 - 7.7e-10 39.2 0.0 1.6e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 PIK58995.1 - 0.0021 17.4 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK58995.1 - 0.02 13.7 0.0 0.035 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PH_11 PF15413.6 PIK58995.1 - 0.11 12.9 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Haspin_kinase PF12330.8 PIK58995.1 - 0.13 11.1 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF2840 PF11000.8 PIK58996.1 - 0.01 15.7 0.0 0.048 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2840) CRAL_TRIO PF00650.20 PIK58997.1 - 2e-09 37.4 0.0 4.3e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 PIK58997.1 - 7.6e-07 29.2 1.5 2e-06 27.9 1.5 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Exo_endo_phos PF03372.23 PIK58997.1 - 0.13 11.7 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family CRAL_TRIO PF00650.20 PIK58998.1 - 1.7e-40 138.3 0.2 1.2e-39 135.5 0.2 2.1 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 PIK58998.1 - 6.8e-09 35.8 0.7 3.3e-08 33.6 0.6 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 PIK58998.1 - 1.4e-05 25.3 0.3 7.4e-05 22.9 0.3 2.2 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain GOLD_2 PF13897.6 PIK58998.1 - 0.051 14.1 0.1 0.23 11.9 0.1 1.9 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking CRAL_TRIO PF00650.20 PIK58999.1 - 2.9e-37 127.9 0.0 4.9e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain EMP24_GP25L PF01105.24 PIK58999.1 - 2.5e-05 24.3 0.3 2.5e-05 24.3 0.3 1.7 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD CRAL_TRIO_2 PF13716.6 PIK58999.1 - 0.014 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 PIK59000.1 - 2.9e-31 108.3 0.2 4.1e-31 107.9 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 PIK59000.1 - 3.3e-07 30.4 2.8 3.3e-07 30.4 2.8 2.4 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 PIK59000.1 - 0.00035 20.8 0.8 0.00069 19.8 0.0 1.8 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain EMP24_GP25L PF01105.24 PIK59000.1 - 0.0086 16.0 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Med21 PF11221.8 PIK59001.1 - 2.9e-28 98.9 9.5 1.1e-27 97.1 9.5 1.8 1 1 0 1 1 1 1 Subunit 21 of Mediator complex TelA PF05816.11 PIK59001.1 - 0.0038 16.4 2.5 0.0042 16.2 2.4 1.2 1 1 0 1 1 1 1 Toxic anion resistance protein (TelA) LMBR1 PF04791.16 PIK59001.1 - 0.39 9.6 1.4 0.4 9.5 1.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.25 PIK59002.1 - 2.5e-63 213.9 0.6 3.4e-63 213.5 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59002.1 - 1.5e-33 116.2 0.1 2e-33 115.8 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK59002.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK59002.1 - 0.011 14.7 1.7 0.022 13.7 1.7 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 PIK59002.1 - 0.016 14.6 0.3 0.028 13.8 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK59002.1 - 0.062 12.1 1.3 2.3 6.9 0.1 2.1 1 1 1 2 2 2 0 Fungal protein kinase rve PF00665.26 PIK59003.1 - 2e-21 76.4 0.0 5e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59003.1 - 4.6e-20 71.5 2.0 1e-19 70.3 2.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK59003.1 - 0.00028 20.6 0.9 0.00091 19.0 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 PIK59003.1 - 0.061 13.6 0.5 0.17 12.1 0.5 1.8 1 0 0 1 1 1 0 H2C2 zinc finger UvrD_C PF13361.6 PIK59003.1 - 0.12 11.7 1.5 0.38 10.1 1.9 1.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain RT_RNaseH_2 PF17919.1 PIK59004.1 - 1.8e-34 117.8 0.1 3.2e-34 117.0 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK59004.1 - 8.2e-34 117.0 0.0 1.4e-33 116.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK59004.1 - 7.9e-32 109.7 0.1 1.5e-31 108.8 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PP2C PF00481.21 PIK59005.1 - 2.6e-35 122.3 0.0 3.2e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK59005.1 - 0.013 15.2 0.4 0.032 13.8 0.4 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C Rep_fac_C PF08542.11 PIK59007.1 - 7.5e-14 51.9 0.1 1.4e-13 51.1 0.1 1.6 1 1 0 1 1 1 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 PIK59007.1 - 3.3e-06 27.3 0.0 5.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain TPR_MalT PF17874.1 PIK59007.1 - 0.0028 17.1 0.0 0.003 17.0 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region Rad17 PF03215.15 PIK59008.1 - 1.2e-10 41.6 0.0 1.3e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 PIK59008.1 - 9.8e-10 39.0 0.0 1.4e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 PIK59008.1 - 4.4e-07 29.8 0.0 0.009 15.8 0.0 2.1 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_11 PF13086.6 PIK59008.1 - 1e-06 28.7 0.0 4.9e-05 23.2 0.0 2.0 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 PIK59008.1 - 1.6e-05 24.7 0.0 2.4e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 PIK59008.1 - 8.5e-05 22.1 0.0 0.0011 18.5 0.0 2.0 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 PIK59008.1 - 8.5e-05 22.8 0.1 0.018 15.3 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 PIK59008.1 - 0.0001 22.8 0.0 0.00013 22.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 PIK59008.1 - 0.00027 20.2 0.0 0.00029 20.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 PIK59008.1 - 0.00039 20.2 0.0 0.00055 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 PIK59008.1 - 0.00076 19.0 0.0 0.02 14.4 0.0 2.1 1 1 1 2 2 2 1 PhoH-like protein ResIII PF04851.15 PIK59008.1 - 0.00097 19.2 0.0 0.0061 16.6 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 PIK59008.1 - 0.0018 18.6 0.0 0.0036 17.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 PIK59008.1 - 0.0025 17.3 0.0 0.029 13.8 0.0 2.0 1 1 0 2 2 2 1 Bacterial TniB protein TIP49 PF06068.13 PIK59008.1 - 0.0042 16.4 0.0 0.0045 16.2 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain DEAD PF00270.29 PIK59008.1 - 0.0048 16.7 0.1 0.14 12.0 0.0 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_5 PF07728.14 PIK59008.1 - 0.012 15.7 0.1 0.028 14.4 0.0 1.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 PIK59008.1 - 0.019 14.7 0.0 0.077 12.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 PIK59008.1 - 0.027 14.5 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK59008.1 - 0.036 14.0 0.0 0.039 13.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 PIK59008.1 - 0.062 12.7 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 PIK59008.1 - 0.074 12.6 0.1 1.3 8.6 0.0 2.1 1 1 1 2 2 2 0 AAA domain T2SSE PF00437.20 PIK59008.1 - 0.081 12.0 0.0 0.098 11.7 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 PIK59008.1 - 0.094 12.4 0.0 0.25 11.0 0.0 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.6 PIK59008.1 - 0.099 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1647 PF07801.11 PIK59009.1 - 1.2e-11 44.5 0.0 1.9e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) DUF1647 PF07801.11 PIK59010.1 - 3.2e-07 30.2 0.0 4.5e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) CNOT11 PF10155.9 PIK59012.1 - 1.1e-53 180.6 6.1 1.9e-53 179.9 6.1 1.4 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 zf-CCHC PF00098.23 PIK59014.1 - 5.7e-12 45.1 13.9 0.00061 19.8 0.7 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK59014.1 - 0.0031 17.4 15.3 0.62 10.1 2.6 3.1 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59014.1 - 0.0066 16.2 1.1 0.0066 16.2 1.1 3.5 2 2 1 3 3 3 2 Zinc knuckle zf-CCHC_5 PF14787.6 PIK59014.1 - 0.013 15.1 0.7 0.013 15.1 0.7 3.2 1 1 2 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 PIK59014.1 - 0.072 12.9 1.1 0.072 12.9 1.1 2.7 3 0 0 3 3 3 0 Zinc knuckle CxC7 PF18866.1 PIK59014.1 - 0.091 12.9 0.3 0.091 12.9 0.3 2.2 2 0 0 2 2 2 0 CxC7 like cysteine cluster associated with KDZ transposases NADH-G_4Fe-4S_3 PF10588.9 PIK59014.1 - 6.7 6.3 10.4 6.2 6.5 1.0 3.1 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region zf-RVT PF13966.6 PIK59015.1 - 0.0017 19.0 2.8 0.0017 19.0 2.8 1.9 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 PIK59016.1 - 1.9e-19 70.1 0.3 2.1e-19 69.9 0.3 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltransf_25 PF13649.6 PIK59017.1 - 1.5e-33 115.4 0.0 4.1e-15 56.3 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 PIK59017.1 - 2.1e-32 111.7 0.0 3e-15 56.6 0.0 2.8 3 0 0 3 3 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59017.1 - 2e-30 105.6 0.1 4.7e-16 59.0 0.0 2.4 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59017.1 - 1.2e-21 77.3 0.0 5.5e-11 42.6 0.0 2.5 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59017.1 - 5.9e-21 75.1 0.0 2.3e-09 37.9 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain Ubie_methyltran PF01209.18 PIK59017.1 - 6.3e-21 74.8 0.0 7.3e-10 38.6 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 PIK59017.1 - 2.5e-10 40.2 0.5 1.3e-09 37.9 0.0 2.3 2 1 1 3 3 3 1 AdoMet dependent proline di-methyltransferase NodS PF05401.11 PIK59017.1 - 8.7e-10 38.6 0.0 5.8e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 Nodulation protein S (NodS) MTS PF05175.14 PIK59017.1 - 5.4e-09 35.8 0.0 0.0006 19.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain TehB PF03848.14 PIK59017.1 - 1.1e-08 34.7 0.0 0.00044 19.7 0.0 2.4 2 0 0 2 2 2 2 Tellurite resistance protein TehB RrnaAD PF00398.20 PIK59017.1 - 1.9e-08 33.7 0.0 6.2e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Ribosomal RNA adenine dimethylase PCMT PF01135.19 PIK59017.1 - 1.3e-07 31.6 0.0 0.0005 19.9 0.0 2.6 3 0 0 3 3 3 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 PIK59017.1 - 5.5e-07 29.2 0.0 2.5e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase CheR PF01739.18 PIK59017.1 - 5.8e-07 29.2 0.1 6.9e-05 22.4 0.1 3.3 3 1 1 4 4 4 1 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 PIK59017.1 - 0.00029 20.8 0.0 0.058 13.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 PIK59017.1 - 0.00084 18.7 0.0 0.34 10.2 0.0 2.4 2 1 0 2 2 2 2 O-methyltransferase domain DRE2_N PF16803.5 PIK59017.1 - 0.016 15.4 0.1 13 6.1 0.0 2.9 2 1 1 3 3 2 0 Fe-S cluster assembly protein DRE2 N-terminus Methyltr_RsmB-F PF01189.17 PIK59017.1 - 0.026 14.2 0.0 0.33 10.6 0.0 2.3 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Pox_MCEL PF03291.16 PIK59017.1 - 0.037 13.1 0.3 0.26 10.4 0.1 2.3 1 1 1 2 2 2 0 mRNA capping enzyme FtsJ PF01728.19 PIK59017.1 - 0.049 13.7 0.1 2.3 8.3 0.0 2.8 2 2 0 2 2 2 0 FtsJ-like methyltransferase DUF938 PF06080.12 PIK59017.1 - 0.051 13.3 0.0 14 5.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF938) Fibrillarin PF01269.17 PIK59017.1 - 0.068 12.3 0.0 8.1 5.5 0.0 2.5 2 1 0 2 2 2 0 Fibrillarin MSV199 PF10553.9 PIK59017.1 - 0.15 12.3 1.9 0.23 11.7 0.4 2.1 2 0 0 2 2 2 0 MSV199 domain Methyltransf_11 PF08241.12 PIK59018.1 - 6.2e-36 122.9 0.0 3e-18 66.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 PIK59018.1 - 1.4e-34 118.7 0.0 5e-17 62.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59018.1 - 2.2e-27 95.7 0.0 2.2e-13 50.3 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59018.1 - 4e-22 78.8 0.0 3.2e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59018.1 - 4.4e-20 72.3 0.0 6.3e-09 36.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 PIK59018.1 - 4.9e-17 62.0 0.0 3.1e-09 36.5 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family MTS PF05175.14 PIK59018.1 - 3.2e-10 39.8 0.0 0.00037 20.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain NodS PF05401.11 PIK59018.1 - 7.5e-10 38.8 0.0 3.2e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Nodulation protein S (NodS) TehB PF03848.14 PIK59018.1 - 7.9e-08 31.9 0.0 0.0006 19.3 0.0 2.2 2 0 0 2 2 2 2 Tellurite resistance protein TehB PCMT PF01135.19 PIK59018.1 - 1.2e-07 31.7 0.0 0.003 17.3 0.0 2.2 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 PIK59018.1 - 1.4e-06 27.9 0.1 0.00018 20.9 0.1 2.2 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_PK PF05891.12 PIK59018.1 - 6.4e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_9 PF08003.11 PIK59018.1 - 3e-05 23.1 0.0 0.15 10.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1698) CheR PF01739.18 PIK59018.1 - 3.6e-05 23.3 0.3 0.031 13.7 0.0 3.7 3 1 1 4 4 4 1 CheR methyltransferase, SAM binding domain RrnaAD PF00398.20 PIK59018.1 - 0.00016 20.9 0.0 0.00061 18.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 PIK59018.1 - 0.00036 19.9 0.0 0.23 10.7 0.0 2.4 2 1 0 2 2 2 2 O-methyltransferase domain Methyltransf_32 PF13679.6 PIK59018.1 - 0.0018 18.3 0.0 0.074 13.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 PIK59018.1 - 0.0024 17.3 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_29 PF03141.16 PIK59018.1 - 0.0025 16.4 0.1 0.03 12.9 0.0 2.5 2 1 1 3 3 3 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TPMT PF05724.11 PIK59018.1 - 0.0068 16.1 0.0 1.3 8.6 0.0 2.9 2 1 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) UPF0020 PF01170.18 PIK59018.1 - 0.011 15.4 0.1 0.31 10.7 0.0 2.6 2 1 1 3 3 3 0 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 PIK59018.1 - 0.016 15.2 0.0 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain DUF938 PF06080.12 PIK59018.1 - 0.021 14.6 0.0 3.4 7.4 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF938) DREV PF05219.12 PIK59018.1 - 0.024 13.7 0.0 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 DREV methyltransferase DUF2194 PF09960.9 PIK59018.1 - 0.038 12.3 0.2 0.2 10.0 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2194) MetW PF07021.12 PIK59018.1 - 0.074 12.6 0.1 0.48 10.0 0.0 2.1 2 1 0 2 2 2 0 Methionine biosynthesis protein MetW Frataxin_Cyay PF01491.16 PIK59018.1 - 3.8 7.6 5.0 8.5 6.5 0.0 3.7 5 1 0 5 5 4 0 Frataxin-like domain Methyltransf_11 PF08241.12 PIK59019.1 - 7.1e-23 81.1 0.0 3e-14 53.4 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 PIK59019.1 - 2.1e-22 79.6 0.0 1.9e-11 44.5 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59019.1 - 3.1e-21 75.8 0.1 2.7e-12 46.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59019.1 - 4.5e-20 72.1 0.0 8.4e-13 48.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59019.1 - 3.9e-16 59.6 0.0 5.9e-08 33.4 0.0 3.2 3 0 0 3 3 3 2 Methyltransferase domain Ubie_methyltran PF01209.18 PIK59019.1 - 5.9e-12 45.4 0.1 1e-05 25.0 0.0 2.8 2 1 0 3 3 3 2 ubiE/COQ5 methyltransferase family NodS PF05401.11 PIK59019.1 - 5.4e-08 32.7 0.0 2.4e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Nodulation protein S (NodS) CheR PF01739.18 PIK59019.1 - 5.7e-07 29.2 0.1 0.00034 20.1 0.0 3.3 2 1 1 3 3 3 1 CheR methyltransferase, SAM binding domain RrnaAD PF00398.20 PIK59019.1 - 2.9e-05 23.3 0.0 4.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.12 PIK59019.1 - 0.0004 20.0 0.3 0.012 15.1 0.0 2.6 2 1 1 3 3 3 1 AdoMet dependent proline di-methyltransferase CMAS PF02353.20 PIK59019.1 - 0.0015 17.9 0.0 0.012 14.9 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 PIK59019.1 - 0.0042 16.0 0.0 0.92 8.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1698) Methyltransf_2 PF00891.18 PIK59019.1 - 0.012 14.9 0.0 2 7.6 0.0 2.3 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_32 PF13679.6 PIK59019.1 - 0.022 14.7 0.0 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 PIK59019.1 - 0.04 13.5 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Met_10 PF02475.16 PIK59019.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_16 PF10294.9 PIK59019.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase zf-C2H2 PF00096.26 PIK59020.1 - 2.6e-28 96.8 49.8 0.0001 22.6 1.3 7.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK59020.1 - 2.3e-27 93.3 45.4 0.00068 20.3 1.1 7.2 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK59020.1 - 1.7e-18 66.2 48.4 2.1e-09 37.3 0.0 8.8 9 0 0 9 9 9 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK59020.1 - 5.5e-10 39.0 44.6 2.7e-06 27.2 1.6 7.5 7 1 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK59020.1 - 2.5e-09 36.7 23.2 0.045 13.5 0.3 6.2 5 1 1 6 6 6 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK59020.1 - 2.6e-09 37.1 44.4 0.036 14.3 0.3 7.3 6 1 1 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK59020.1 - 1.6e-08 34.8 33.2 0.042 14.2 0.7 5.7 2 2 3 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 PIK59020.1 - 3.8e-07 30.3 37.1 0.35 11.3 0.2 6.6 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2HE PF16278.5 PIK59020.1 - 2.5e-05 24.7 28.8 0.00068 20.0 0.6 6.2 3 2 2 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 PIK59020.1 - 3.7e-05 23.2 20.9 0.04 13.5 0.7 5.7 6 0 0 6 6 5 2 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 PIK59020.1 - 6.4e-05 23.6 15.3 0.03 15.0 0.9 4.7 2 1 1 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 PIK59020.1 - 0.00016 21.9 5.1 0.00016 21.9 5.1 3.5 2 1 1 3 3 3 1 C2H2-type zinc ribbon zf-BED PF02892.15 PIK59020.1 - 0.0011 19.0 28.0 0.35 10.9 1.2 5.9 4 2 2 6 6 6 4 BED zinc finger GAGA PF09237.11 PIK59020.1 - 0.0014 18.4 1.4 0.66 9.8 0.4 2.7 2 0 0 2 2 2 1 GAGA factor zinc_ribbon_15 PF17032.5 PIK59020.1 - 0.0082 16.9 25.7 0.17 12.6 0.9 4.1 3 1 1 4 4 4 1 zinc-ribbon family zf-C2H2_9 PF16293.5 PIK59020.1 - 0.016 15.0 14.2 3.5 7.5 0.1 5.9 5 1 1 6 6 6 0 C2H2 type zinc-finger (1 copy) Zn_ribbon_recom PF13408.6 PIK59020.1 - 0.018 15.5 0.9 0.018 15.5 0.9 3.9 3 1 0 3 3 3 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 PIK59020.1 - 0.021 15.1 1.3 0.021 15.1 1.3 4.3 3 2 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 PIK59020.1 - 0.035 14.2 30.2 1.6 8.9 0.2 5.9 5 2 0 5 5 5 0 Zinc ribbon domain PyrI_C PF02748.15 PIK59020.1 - 0.05 13.5 0.1 0.05 13.5 0.1 5.1 5 2 0 5 5 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain T4_Gp59_N PF08993.10 PIK59020.1 - 0.11 12.9 1.3 0.26 11.7 1.3 1.7 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase HNH_5 PF14279.6 PIK59020.1 - 0.18 11.7 17.0 10 6.0 0.1 5.8 5 1 1 6 6 6 0 HNH endonuclease BolA PF01722.18 PIK59020.1 - 0.23 11.8 3.4 0.34 11.2 0.3 2.6 3 0 0 3 3 3 0 BolA-like protein PriA_CRR PF18319.1 PIK59020.1 - 0.25 11.4 0.2 0.25 11.4 0.2 5.3 6 0 0 6 6 5 0 PriA DNA helicase Cys-rich region (CRR) domain zf_ZIC PF18366.1 PIK59020.1 - 0.25 11.5 0.1 0.25 11.5 0.1 5.4 4 2 2 6 6 6 0 Zic proteins zinc finger domain C1_4 PF07975.12 PIK59020.1 - 0.28 11.4 33.1 0.1 12.9 2.7 5.2 2 2 5 7 7 7 0 TFIIH C1-like domain zf-AN1 PF01428.16 PIK59020.1 - 0.4 10.9 27.8 5 7.4 0.2 6.6 7 0 0 7 7 6 0 AN1-like Zinc finger HypA PF01155.19 PIK59020.1 - 1.8 8.6 20.2 8.7 6.4 0.5 4.0 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zf_RING PF16744.5 PIK59020.1 - 2.2 8.4 18.9 9.5 6.4 1.0 4.8 3 1 2 5 5 5 0 KIAA1045 RING finger Mut7-C PF01927.16 PIK59020.1 - 7.2 6.7 17.5 4.4 7.4 8.4 3.6 2 1 0 2 2 2 0 Mut7-C RNAse domain TF_Zn_Ribbon PF08271.12 PIK59020.1 - 7.3 6.2 20.6 3.3 7.3 0.2 5.5 6 0 0 6 6 6 0 TFIIB zinc-binding Evr1_Alr PF04777.13 PIK59020.1 - 9.9 6.7 25.2 4.1 7.9 2.0 5.2 2 2 1 3 3 3 0 Erv1 / Alr family Methyltransf_11 PF08241.12 PIK59021.1 - 0.17 12.5 0.1 0.99 10.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain zf-C2H2_4 PF13894.6 PIK59022.1 - 0.00012 22.6 20.7 0.023 15.5 6.7 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK59022.1 - 0.024 15.1 18.9 0.028 14.9 2.9 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.26 PIK59022.1 - 0.037 14.5 21.9 0.038 14.4 3.9 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK59022.1 - 9.6 6.6 13.2 14 6.1 1.4 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK59022.1 - 9.8 6.0 16.6 6.9 6.5 4.9 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 PIK59023.1 - 7.5e-17 60.8 43.2 5.4e-05 23.4 1.3 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK59023.1 - 8.4e-16 57.6 39.3 6.6e-07 29.5 0.7 6.7 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK59023.1 - 3.6e-14 52.2 43.2 0.0016 19.1 0.4 5.8 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK59023.1 - 6.1e-10 38.7 2.3 6.1e-10 38.7 2.3 6.0 7 0 0 7 7 7 3 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 PIK59023.1 - 1.8e-05 25.0 29.7 0.94 9.8 0.1 5.2 1 1 4 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 PIK59023.1 - 0.0027 18.4 21.9 0.52 11.0 0.6 4.1 2 2 1 4 4 4 2 Zinc finger C2H2-type, 3 repeats DUF4599 PF15371.6 PIK59023.1 - 0.008 16.7 2.0 0.011 16.3 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4599) zf-C2H2_6 PF13912.6 PIK59023.1 - 0.11 12.5 0.1 0.11 12.5 0.1 4.9 7 0 0 7 7 5 0 C2H2-type zinc finger OrsD PF12013.8 PIK59023.1 - 0.36 11.3 26.3 0.12 12.8 5.7 4.6 2 2 3 5 5 5 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_jaz PF12171.8 PIK59023.1 - 0.4 11.0 0.1 0.4 11.0 0.1 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_7 PF15269.6 PIK59023.1 - 0.43 10.7 0.1 0.43 10.7 0.1 4.2 3 1 2 5 5 5 0 Zinc-finger zf-C2H2_9 PF16293.5 PIK59023.1 - 1.2 9.1 11.8 1.5 8.8 0.1 3.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_aberr PF17017.5 PIK59023.1 - 2.3 8.3 12.7 16 5.6 6.9 2.6 2 1 0 2 2 2 0 Aberrant zinc-finger Zn_ribbon_SprT PF17283.2 PIK59023.1 - 2.5 8.1 8.4 38 4.3 2.9 3.7 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zf-met PF12874.7 PIK59023.1 - 4 8.0 34.2 0.59 10.6 0.8 6.0 6 1 0 6 6 6 0 Zinc-finger of C2H2 type DUF629 PF04780.12 PIK59023.1 - 6.2 5.2 24.5 0.058 11.9 6.7 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 PIK59024.1 - 8e-18 63.8 13.1 4.3e-07 30.0 1.2 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK59024.1 - 1.5e-14 53.4 9.8 3.8e-05 24.2 0.3 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK59024.1 - 1.5e-13 50.6 1.5 0.00031 20.9 0.0 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK59024.1 - 4.4e-13 49.0 8.6 5e-08 33.0 0.0 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 PIK59024.1 - 5e-12 45.8 6.8 0.00032 21.0 0.1 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK59024.1 - 1.4e-07 31.1 7.5 0.00035 20.3 0.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_9 PF16293.5 PIK59024.1 - 1.7e-05 24.6 5.5 0.2 11.5 0.1 3.2 2 1 1 3 3 3 3 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 PIK59024.1 - 1.8e-05 24.4 12.0 0.0069 16.1 2.8 2.8 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 PIK59024.1 - 0.00012 22.0 9.1 0.029 14.4 0.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK59024.1 - 0.00049 20.3 7.5 0.035 14.4 2.4 2.7 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-Sec23_Sec24 PF04810.15 PIK59024.1 - 0.0028 17.6 3.8 4.9 7.3 0.1 3.2 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger zf-C2H2_2 PF12756.7 PIK59024.1 - 0.0046 17.3 9.8 16 5.9 10.8 3.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 PIK59024.1 - 0.016 15.5 2.0 0.049 13.9 2.0 1.7 1 1 0 1 1 1 0 C2H2-type zinc ribbon CTU2 PF10288.9 PIK59024.1 - 0.042 14.1 8.1 0.8 10.0 4.3 2.8 1 1 2 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 FYDLN_acid PF09538.10 PIK59024.1 - 0.048 14.4 1.3 0.056 14.1 0.1 1.7 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) Elf1 PF05129.13 PIK59024.1 - 0.055 13.5 5.5 1.7 8.8 1.1 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DZR PF12773.7 PIK59024.1 - 0.087 12.9 3.7 0.29 11.2 3.7 1.8 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 PIK59024.1 - 0.097 13.4 2.2 0.91 10.3 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 PIK59024.1 - 0.12 13.0 2.8 5.2 7.8 0.4 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats OrfB_Zn_ribbon PF07282.11 PIK59024.1 - 0.17 11.9 3.2 0.25 11.3 1.0 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain C1_2 PF03107.16 PIK59024.1 - 0.18 12.2 8.2 1.4 9.3 3.7 3.1 1 1 1 2 2 2 0 C1 domain GAGA PF09237.11 PIK59024.1 - 0.18 11.6 7.7 0.48 10.3 0.0 3.3 2 1 2 4 4 3 0 GAGA factor zf_UBZ PF18439.1 PIK59024.1 - 0.23 11.1 3.9 12 5.6 0.2 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Actin_micro PF17003.5 PIK59024.1 - 0.57 9.3 6.1 1.9 7.6 0.2 2.6 1 1 2 3 3 3 0 Putative actin-like family Zn-C2H2_12 PF18112.1 PIK59024.1 - 0.68 10.5 0.1 0.68 10.5 0.1 3.3 3 1 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Ima1_N PF09779.9 PIK59024.1 - 0.9 10.4 7.7 0.28 12.0 3.5 2.1 1 1 1 2 2 2 0 Ima1 N-terminal domain zf-C2H2_3 PF13878.6 PIK59024.1 - 3.3 7.6 10.3 8.2 6.3 0.1 3.3 1 1 2 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-RING_5 PF14634.6 PIK59024.1 - 3.4 7.7 7.9 13 5.8 0.2 2.9 2 1 1 3 3 3 0 zinc-RING finger domain UBZ_FAAP20 PF15750.5 PIK59024.1 - 4.6 7.3 8.2 13 5.8 0.6 3.3 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger PEPCK_GTP PF00821.18 PIK59025.1 - 3.5e-105 351.8 0.7 4.1e-105 351.5 0.7 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 PIK59026.1 - 8.2e-30 104.0 0.1 1.1e-29 103.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Pkinase PF00069.25 PIK59027.1 - 9e-61 205.5 0.0 1.2e-60 205.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59027.1 - 6.5e-40 137.0 0.0 1.1e-39 136.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59027.1 - 5.5e-06 25.9 0.0 1.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK59027.1 - 0.0012 17.9 0.0 0.0023 16.9 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 PIK59027.1 - 0.01 15.8 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF5507 PF17612.2 PIK59027.1 - 0.021 14.5 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5507) Kdo PF06293.14 PIK59027.1 - 0.048 13.0 0.2 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK59027.1 - 0.75 9.3 4.2 2 7.9 0.1 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase Snf7 PF03357.21 PIK59028.1 - 9e-13 48.2 15.9 1.1e-12 47.9 15.9 1.2 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 PIK59028.1 - 2e-06 27.8 5.1 2.8e-06 27.4 5.1 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DMSP_lyase PF16867.5 PIK59028.1 - 0.011 15.4 0.8 0.017 14.8 0.1 1.7 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase UPF0176_N PF17773.1 PIK59028.1 - 0.12 12.8 1.6 1 9.7 0.0 2.4 2 1 0 2 2 2 0 UPF0176 acylphosphatase like domain GrpE PF01025.19 PIK59028.1 - 0.13 11.9 9.9 0.11 12.2 8.4 1.6 1 1 0 1 1 1 0 GrpE HSCB_C PF07743.13 PIK59028.1 - 0.24 11.9 7.3 1.9 9.1 2.4 3.4 2 1 2 4 4 4 0 HSCB C-terminal oligomerisation domain DUF1104 PF06518.11 PIK59028.1 - 0.61 10.5 8.6 1.9 8.9 3.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) UPF0242 PF06785.11 PIK59028.1 - 9.2 6.3 11.1 0.92 9.6 0.3 2.1 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-N PF05238.13 PIK59029.1 - 2.6e-29 102.8 0.1 3.7e-29 102.3 0.1 1.2 1 0 0 1 1 1 1 Kinetochore protein CHL4 like GCR1_C PF12550.8 PIK59029.1 - 0.012 15.9 0.2 4.3 7.7 0.1 2.5 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes MetOD2 PF18548.1 PIK59029.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Metanogen output domain 2 F-box-like PF12937.7 PIK59030.1 - 1.4e-09 37.7 3.0 2e-09 37.2 1.4 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK59030.1 - 8.1e-06 25.6 1.0 8.1e-06 25.6 1.0 2.5 2 0 0 2 2 2 1 F-box domain EF-hand_6 PF13405.6 PIK59031.1 - 0.001 18.8 0.1 0.09 12.8 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 PIK59031.1 - 0.0032 16.9 0.2 0.14 11.8 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 PIK59031.1 - 0.0059 16.4 0.2 0.015 15.1 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 PIK59031.1 - 0.02 15.3 3.2 0.55 10.7 0.1 2.8 2 1 0 3 3 3 0 EF-hand domain pair SesA PF17107.5 PIK59031.1 - 0.059 13.6 0.9 0.55 10.4 0.5 2.6 1 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Glyco_transf_29 PF00777.18 PIK59032.1 - 6.9e-66 222.4 0.3 1.4e-65 221.4 0.1 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) HcyBio PF01837.16 PIK59032.1 - 0.0023 16.8 0.1 0.0035 16.2 0.1 1.2 1 0 0 1 1 1 1 Homocysteine biosynthesis enzyme, sulfur-incorporation RT_RNaseH_2 PF17919.1 PIK59033.1 - 1.4e-31 108.4 0.0 3.3e-31 107.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK59033.1 - 3.4e-27 94.8 0.0 8.8e-27 93.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK59033.1 - 5.6e-17 62.0 0.1 1.3e-16 60.8 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.6 PIK59033.1 - 0.0028 17.3 5.7 0.007 16.0 5.7 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Retrotrans_gag PF03732.17 PIK59033.1 - 0.0065 16.7 0.9 0.036 14.3 0.2 2.7 2 0 0 2 2 2 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 PIK59033.1 - 0.012 16.3 0.0 0.041 14.5 0.0 1.9 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 PIK59033.1 - 0.044 14.3 0.3 0.2 12.3 0.0 2.3 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease FIBP PF05427.11 PIK59033.1 - 0.048 12.9 0.4 0.088 12.1 0.4 1.3 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) zf-CCHC PF00098.23 PIK59033.1 - 4.9 7.4 14.8 0.036 14.1 4.1 2.8 2 1 0 2 2 2 0 Zinc knuckle Ndr PF03096.14 PIK59034.1 - 7.2e-107 356.3 0.1 1.4e-106 355.4 0.0 1.4 2 0 0 2 2 2 1 Ndr family Abhydrolase_1 PF00561.20 PIK59034.1 - 1.5e-05 24.8 0.1 2.3e-05 24.2 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Fijivirus_P9-2 PF06837.11 PIK59034.1 - 0.14 11.6 0.1 0.14 11.6 0.1 1.8 2 0 0 2 2 2 0 Fijivirus P9-2 protein p450 PF00067.22 PIK59036.1 - 3.6e-102 342.5 0.0 4.5e-102 342.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4965 PF16335.5 PIK59036.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4965) Ldl_recept_a PF00057.18 PIK59037.1 - 2.6e-15 56.4 31.8 1.8e-12 47.3 11.7 4.6 4 1 1 5 5 5 2 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK59037.1 - 6.5e-13 49.0 1.8 1.2e-05 25.6 0.0 3.3 3 0 0 3 3 3 2 CUB domain Anoctamin PF04547.12 PIK59038.1 - 6e-58 196.8 0.8 7.2e-58 196.5 0.8 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Cyt_bd_oxida_II PF02322.15 PIK59038.1 - 0.0019 17.6 0.3 0.0027 17.1 0.3 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II Ribosomal_L13e PF01294.18 PIK59039.1 - 3.1e-69 232.4 4.3 4.7e-69 231.9 4.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e tRNA-synt_1 PF00133.22 PIK59040.1 - 6.9e-47 160.0 0.5 6.6e-21 74.2 1.0 6.2 3 2 2 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 PIK59040.1 - 1.3e-26 93.3 0.3 3e-18 65.8 0.0 4.1 3 1 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 PIK59040.1 - 1.7e-19 70.0 0.0 5.3e-19 68.5 0.0 1.8 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Anticodon_1 PF08264.13 PIK59040.1 - 2.8e-14 53.4 0.5 5.3e-14 52.4 0.5 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 PIK59040.1 - 0.03 13.3 0.0 6.1 5.6 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) zf-ribbon_3 PF13248.6 PIK59040.1 - 0.038 13.4 3.1 0.62 9.5 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_4 PF13894.6 PIK59041.1 - 0.0025 18.5 20.1 0.013 16.3 4.8 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK59041.1 - 0.0084 16.5 4.8 0.0084 16.5 4.8 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK59041.1 - 0.0088 16.4 14.5 0.009 16.4 1.5 3.3 2 1 1 3 3 3 2 Zinc-finger double domain DUF2321 PF10083.9 PIK59041.1 - 0.047 13.3 0.1 0.052 13.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Peptidase_C97 PF05903.14 PIK59041.1 - 0.058 13.2 0.3 0.065 13.1 0.3 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain Elf1 PF05129.13 PIK59041.1 - 0.082 13.0 1.7 0.12 12.5 1.1 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C2H2_jaz PF12171.8 PIK59042.1 - 0.47 10.8 5.9 0.98 9.8 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK59042.1 - 3.7 8.6 8.8 2.4 9.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DDE_Tnp_4 PF13359.6 PIK59044.1 - 6.4e-17 61.7 0.0 1e-16 61.0 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.23 PIK59046.1 - 2.6e-07 30.4 15.8 0.0005 20.0 0.2 3.8 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK59046.1 - 0.00035 20.3 8.0 0.076 12.9 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59046.1 - 0.015 15.0 11.3 3.8 7.3 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59046.1 - 0.017 15.0 0.2 0.017 15.0 0.2 3.1 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK59046.1 - 0.017 14.8 0.8 0.017 14.8 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 PIK59046.1 - 0.017 15.1 16.0 0.19 11.7 1.3 3.7 2 1 2 4 4 4 0 Zinc knuckle RVT_1 PF00078.27 PIK59048.1 - 4.4e-18 65.6 0.0 5.8e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Albumin_I PF08027.11 PIK59049.1 - 6.1 6.5 10.5 0.19 11.3 4.0 1.9 2 0 0 2 2 2 0 Albumin I chain b DUF4871 PF16167.5 PIK59050.1 - 0.062 13.3 0.7 6.6 6.8 0.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4871) zf-CCHC PF00098.23 PIK59051.1 - 6.2e-06 26.1 16.1 0.0024 17.9 3.3 3.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59051.1 - 2.9e-05 23.8 6.2 0.0022 17.8 0.2 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59051.1 - 4.4e-05 23.1 13.2 0.19 11.5 0.6 3.3 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK59051.1 - 8.6 6.7 16.5 0.36 11.1 6.8 2.6 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 PIK59052.1 - 4.2e-06 26.4 0.0 1.3e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK59052.1 - 0.088 12.3 0.7 0.16 11.4 0.7 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Lsm_interact PF05391.11 PIK59054.1 - 0.013 15.0 1.3 0.083 12.4 0.0 2.7 2 0 0 2 2 2 0 Lsm interaction motif HlyC PF02794.16 PIK59054.1 - 0.067 13.1 0.4 0.42 10.5 0.1 1.9 1 1 1 2 2 2 0 RTX toxin acyltransferase family DDE_Tnp_4 PF13359.6 PIK59055.1 - 8.2e-31 106.8 0.0 1.4e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 PIK59055.1 - 1.8e-07 31.0 0.0 2.1e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 PIK59055.1 - 2e-07 30.8 0.0 2e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Transposase DDE domain zf-CCHC PF00098.23 PIK59056.1 - 7.7e-06 25.8 16.1 0.0025 17.8 3.3 3.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59056.1 - 2.1e-05 24.2 6.2 0.0023 17.7 0.2 3.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59056.1 - 0.00013 21.7 14.3 0.37 10.6 1.1 3.4 2 1 1 3 3 3 3 Zinc knuckle IBR PF01485.21 PIK59056.1 - 0.92 9.8 12.4 0.43 10.8 6.9 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_10 PF16588.5 PIK59056.1 - 2 8.2 12.9 0.69 9.7 0.3 4.1 4 0 0 4 4 4 0 C2H2 zinc-finger rve PF00665.26 PIK59058.1 - 1.2e-25 90.1 0.1 2e-25 89.3 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59058.1 - 2.3e-19 69.2 1.4 4.4e-19 68.3 1.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK59058.1 - 5.6e-10 39.5 0.0 2.1e-09 37.6 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK59058.1 - 5.4e-05 22.9 0.1 0.00015 21.4 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK59058.1 - 0.00013 22.0 0.7 0.00034 20.8 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK59058.1 - 0.0041 17.1 0.0 0.012 15.6 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Gifsy-2 PF13856.6 PIK59058.1 - 0.14 12.5 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage RVT_1 PF00078.27 PIK59059.1 - 3.2e-18 66.1 0.1 3.9e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK59060.1 - 1.4e-08 35.1 0.0 6.1e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK59060.1 - 2.7e-07 31.1 0.1 3.5e-06 27.6 0.0 2.5 2 0 0 2 2 2 1 Aspartyl protease PNMA PF14893.6 PIK59060.1 - 0.00013 21.5 1.9 0.0013 18.2 0.0 2.2 2 0 0 2 2 2 1 PNMA RVP PF00077.20 PIK59060.1 - 0.0003 21.1 0.1 0.00086 19.6 0.1 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease SlyX PF04102.12 PIK59060.1 - 0.033 14.8 1.6 0.33 11.6 0.2 2.7 2 0 0 2 2 2 0 SlyX bZIP_1 PF00170.21 PIK59061.1 - 0.0015 18.6 3.0 0.0033 17.5 3.0 1.5 1 0 0 1 1 1 1 bZIP transcription factor BEN PF10523.9 PIK59061.1 - 0.015 15.5 0.1 0.069 13.4 0.0 1.9 2 0 0 2 2 2 0 BEN domain SPX PF03105.19 PIK59061.1 - 0.024 14.6 1.7 0.028 14.4 1.7 1.1 1 0 0 1 1 1 0 SPX domain IFP_35_N PF07334.13 PIK59061.1 - 0.03 14.4 2.8 0.082 13.0 2.8 1.8 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus NPV_P10 PF05531.12 PIK59061.1 - 1.2 9.6 4.8 3.3 8.3 2.4 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4218 PF13960.6 PIK59062.1 - 0.00013 21.5 0.0 0.00025 20.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DUF4050 PF13259.6 PIK59062.1 - 0.093 13.0 0.7 0.15 12.4 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) EF-hand_7 PF13499.6 PIK59064.1 - 0.00053 20.4 0.2 0.0021 18.5 0.0 2.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK59064.1 - 0.0034 17.2 0.1 0.0094 15.8 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK59064.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.7 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 PIK59064.1 - 0.025 14.5 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 PIK59064.1 - 0.18 11.3 0.0 0.82 9.3 0.0 1.9 2 0 0 2 2 2 0 EF hand BDHCT_assoc PF16204.5 PIK59065.1 - 0.026 14.2 6.4 0.047 13.4 6.4 1.4 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein DUF4692 PF15763.5 PIK59065.1 - 4.2 7.8 7.8 7.4 7.0 7.8 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Cupin_8 PF13621.6 PIK59066.1 - 9.2e-10 38.7 0.1 7.2e-08 32.4 0.0 2.7 2 1 1 3 3 3 1 Cupin-like domain JmjC PF02373.22 PIK59066.1 - 0.0013 19.1 0.1 0.016 15.6 0.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase TFIID-18kDa PF02269.16 PIK59066.1 - 0.093 12.8 1.1 6 7.0 0.1 2.3 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit 3-HAO PF06052.12 PIK59066.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase DUF2140 PF09911.9 PIK59066.1 - 0.26 10.8 2.3 0.45 10.0 2.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) C2 PF00168.30 PIK59067.1 - 1.5e-49 166.5 0.7 1.5e-24 86.3 0.0 2.2 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 PIK59067.1 - 1.7e-09 37.7 0.1 0.0011 18.9 0.0 2.7 2 1 1 3 3 3 2 Phosphoinositide 3-kinase C2 DOCK-C2 PF14429.6 PIK59067.1 - 0.00024 21.0 0.3 0.0095 15.8 0.0 2.1 1 1 1 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF1494 PF07379.11 PIK59067.1 - 0.038 13.8 0.1 0.19 11.6 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1494) Metallophos_3 PF14582.6 PIK59067.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily DeoC PF01791.9 PIK59068.1 - 3e-20 72.9 0.1 4e-20 72.4 0.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase Herpes_glycop PF01528.16 PIK59068.1 - 0.077 11.8 0.1 0.099 11.5 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF4516 PF14990.6 PIK59068.1 - 0.22 11.3 0.9 0.41 10.4 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4516) Neur_chan_memb PF02932.16 PIK59069.1 - 3.6e-15 56.7 0.1 4.3e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK59069.1 - 1e-05 25.1 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain His_Phos_2 PF00328.22 PIK59070.1 - 6.9e-15 55.3 2.6 8.2e-15 55.0 1.1 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) 7tm_2 PF00002.24 PIK59071.1 - 9.1e-20 71.0 21.0 2e-19 69.9 21.0 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK59071.1 - 0.003 17.9 11.3 0.01 16.2 11.3 2.0 1 0 0 1 1 1 1 Somatomedin B domain 7tm_2 PF00002.24 PIK59072.1 - 6e-17 61.7 21.2 9.6e-17 61.1 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Somatomedin_B PF01033.17 PIK59072.1 - 0.0015 18.8 9.9 0.0047 17.3 9.9 1.9 1 0 0 1 1 1 1 Somatomedin B domain Asp_protease_2 PF13650.6 PIK59073.1 - 1.7e-06 28.6 0.1 4.8e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK59073.1 - 2.2e-06 28.1 0.1 7.6e-06 26.4 0.1 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease DUF1758 PF05585.12 PIK59073.1 - 0.0023 17.7 0.2 0.0034 17.2 0.2 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Phage_head_fibr PF11133.8 PIK59073.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Head fiber protein Cytomega_TRL10 PF06084.11 PIK59073.1 - 0.64 10.0 4.0 1 9.3 4.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein zf-Di19 PF05605.12 PIK59074.1 - 4.3e-05 23.7 7.4 0.04 14.2 0.4 3.6 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding SPT6_acidic PF14632.6 PIK59074.1 - 9.8e-05 22.9 5.3 0.16 12.6 0.7 2.8 2 0 0 2 2 2 2 Acidic N-terminal SPT6 Defensin_1 PF00323.19 PIK59074.1 - 0.00051 20.5 7.8 0.35 11.5 1.9 3.1 2 0 0 2 2 2 2 Mammalian defensin zf-C2H2_4 PF13894.6 PIK59074.1 - 0.031 15.1 16.8 0.85 10.6 1.2 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3970 PF13113.6 PIK59074.1 - 0.034 14.4 0.4 5.6 7.3 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3970) DDE_3 PF13358.6 PIK59074.1 - 0.07 12.9 0.8 9.8 5.9 0.1 2.4 2 0 0 2 2 2 0 DDE superfamily endonuclease DUF2316 PF10078.9 PIK59074.1 - 0.99 9.7 3.2 15 5.9 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) zf-tcix PF14952.6 PIK59074.1 - 1.2 8.9 9.6 2 8.1 2.5 2.9 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.6 PIK59074.1 - 2.7 7.5 5.9 24 4.5 0.6 2.8 2 0 0 2 2 2 0 zinc-ribbon domain Zn-C2H2_12 PF18112.1 PIK59074.1 - 7 7.2 10.4 0.7 10.4 0.3 3.0 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain SET PF00856.28 PIK59075.1 - 2.5e-10 41.0 1.0 2.5e-09 37.7 0.1 2.6 2 1 0 2 2 2 1 SET domain NPL PF17800.1 PIK59076.1 - 3.6e-10 40.3 0.3 1.1e-09 38.8 0.1 1.9 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-H2C2_2 PF13465.6 PIK59077.1 - 4.4e-08 33.2 22.5 2.2e-06 27.8 2.0 4.8 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK59077.1 - 2.5e-07 31.0 39.6 0.026 15.3 0.5 5.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf_C2H2_6 PF18450.1 PIK59077.1 - 3e-05 23.6 4.1 3e-05 23.6 4.1 2.7 1 1 1 2 2 2 1 Zinc Finger domain zf-C2H2 PF00096.26 PIK59077.1 - 0.00011 22.4 37.0 0.00087 19.6 0.9 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type DHFR_1 PF00186.19 PIK59077.1 - 0.056 13.1 0.0 0.084 12.6 0.0 1.4 1 1 0 1 1 1 0 Dihydrofolate reductase BolA PF01722.18 PIK59077.1 - 1 9.7 4.5 1.2 9.4 1.2 2.3 2 1 0 2 2 2 0 BolA-like protein zf-H2C2_2 PF13465.6 PIK59078.1 - 2.1e-29 100.6 53.4 6.1e-06 26.4 0.1 8.1 8 1 1 9 9 8 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK59078.1 - 7.2e-28 95.5 58.7 9.2e-07 29.0 1.0 7.9 8 0 0 8 8 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK59078.1 - 1.4e-24 84.6 54.4 0.00023 21.7 0.7 7.8 7 1 1 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK59078.1 - 3.3e-13 49.5 39.2 0.028 14.7 0.7 7.5 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK59078.1 - 2e-11 43.6 48.2 0.0023 17.9 0.3 8.4 8 0 0 8 8 8 6 C2H2-type zinc finger zf-met PF12874.7 PIK59078.1 - 4e-08 33.4 42.4 0.0015 18.8 0.3 7.8 8 0 0 8 8 7 3 Zinc-finger of C2H2 type zf-BED PF02892.15 PIK59078.1 - 1.1e-06 28.6 48.8 0.078 13.0 6.1 7.3 1 1 6 7 7 7 5 BED zinc finger SET PF00856.28 PIK59078.1 - 0.0044 17.4 1.1 0.0063 16.9 0.0 1.8 2 1 0 2 2 2 1 SET domain zf-C2H2_3rep PF18868.1 PIK59078.1 - 0.019 15.6 25.4 0.68 10.6 6.2 5.4 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 PIK59078.1 - 0.019 15.3 37.9 5.3 7.4 3.4 6.9 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 PIK59078.1 - 0.026 14.4 0.3 0.026 14.4 0.3 5.8 5 2 2 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-RING_11 PF17123.5 PIK59078.1 - 0.033 13.9 2.6 38 4.2 0.1 4.5 4 0 0 4 4 4 0 RING-like zinc finger GAGA PF09237.11 PIK59078.1 - 0.051 13.4 11.3 0.28 11.0 0.1 4.1 2 2 2 4 4 4 0 GAGA factor BolA PF01722.18 PIK59078.1 - 0.053 13.8 8.4 0.97 9.8 0.2 4.1 2 2 2 4 4 4 0 BolA-like protein zinc_ribbon_15 PF17032.5 PIK59078.1 - 0.15 12.9 26.2 0.6 10.9 0.7 4.2 1 1 3 4 4 4 0 zinc-ribbon family zf-C2HC_2 PF13913.6 PIK59078.1 - 0.28 11.1 35.7 0.95 9.4 0.4 6.6 7 0 0 7 7 6 0 zinc-finger of a C2HC-type C1_2 PF03107.16 PIK59078.1 - 0.3 11.5 36.3 23 5.4 0.2 7.1 2 2 3 5 5 5 0 C1 domain DUF2256 PF10013.9 PIK59078.1 - 0.31 11.2 24.6 2 8.6 0.0 6.8 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-met2 PF12907.7 PIK59078.1 - 1 9.6 19.2 5.7 7.2 0.7 5.3 5 0 0 5 5 5 0 Zinc-binding Zf_RING PF16744.5 PIK59078.1 - 1.8 8.8 30.5 1.6 8.9 0.1 7.3 3 1 5 8 8 8 0 KIAA1045 RING finger zf-MYST PF17772.1 PIK59078.1 - 8.1 6.1 17.2 21 4.8 0.2 4.6 3 2 2 5 5 5 0 MYST family zinc finger domain zf-C2H2_9 PF16293.5 PIK59078.1 - 8.5 6.3 14.0 12 5.8 0.5 5.6 4 2 3 7 7 7 0 C2H2 type zinc-finger (1 copy) YHYH PF14240.6 PIK59079.1 - 2.1e-20 73.5 2.4 5.9e-12 45.9 0.2 2.2 1 1 1 2 2 2 2 YHYH protein zf-C3HC4_2 PF13923.6 PIK59081.1 - 1.9e-10 40.4 9.5 3.1e-10 39.7 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK59081.1 - 1.9e-09 37.2 10.7 3.3e-09 36.5 10.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK59081.1 - 1.1e-06 28.8 8.2 1.9e-06 28.1 8.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK59081.1 - 1.3e-06 28.2 9.4 2.1e-06 27.5 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK59081.1 - 1.1e-05 25.6 5.4 2.1e-05 24.7 5.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK59081.1 - 0.00012 22.1 6.1 0.00026 20.9 6.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK59081.1 - 0.00053 19.9 12.7 0.0013 18.6 11.6 2.0 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK59081.1 - 0.0036 17.1 10.4 0.0046 16.8 9.5 1.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 PIK59081.1 - 0.0044 17.1 10.4 0.0086 16.2 10.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SIR2_2 PF13289.6 PIK59081.1 - 0.016 15.3 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 SIR2-like domain zf-Nse PF11789.8 PIK59081.1 - 0.02 14.7 6.1 0.045 13.6 6.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 PIK59081.1 - 0.035 14.2 3.4 0.061 13.4 3.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 PIK59081.1 - 0.51 10.5 9.3 1.8 8.7 8.5 2.1 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4_5 PF17121.5 PIK59081.1 - 0.51 10.3 4.3 0.96 9.4 4.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 PIK59081.1 - 0.99 9.1 7.7 2.7 7.7 7.7 1.7 1 1 0 1 1 1 0 P-11 zinc finger DUF1272 PF06906.11 PIK59081.1 - 1.2 9.3 4.7 2.8 8.1 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 PIK59081.1 - 4.4 7.2 7.2 10 6.0 7.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Retrotrans_gag PF03732.17 PIK59082.1 - 0.0039 17.4 0.1 0.0089 16.3 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein ZT_dimer PF16916.5 PIK59082.1 - 0.12 12.5 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter RVT_1 PF00078.27 PIK59083.1 - 3.3e-23 82.4 0.1 5.8e-23 81.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HxlR PF01638.17 PIK59083.1 - 0.085 12.7 0.1 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 HxlR-like helix-turn-helix DUF4542 PF15075.6 PIK59083.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) RVT_2 PF07727.14 PIK59084.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK59085.1 - 3e-18 66.1 0.0 6.7e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 PIK59085.1 - 1.9e-07 31.0 0.0 2.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS240 PF13610.6 PIK59085.1 - 0.0073 16.5 0.2 0.027 14.7 0.0 2.0 3 0 0 3 3 3 1 DDE domain rve_3 PF13683.6 PIK59085.1 - 0.01 15.6 0.0 0.037 13.8 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain IN_DBD_C PF00552.21 PIK59085.1 - 0.057 12.7 0.1 0.15 11.4 0.1 1.6 1 0 0 1 1 1 0 Integrase DNA binding domain TadF PF16964.5 PIK59085.1 - 0.12 12.1 0.0 1.6 8.4 0.0 2.1 2 0 0 2 2 2 0 Putative tight adherence pilin protein F RVT_1 PF00078.27 PIK59086.1 - 1e-20 74.2 0.0 1.7e-20 73.5 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tektin PF03148.14 PIK59086.1 - 0.11 11.2 0.3 0.16 10.7 0.3 1.1 1 0 0 1 1 1 0 Tektin family Xan_ur_permease PF00860.20 PIK59087.1 - 2e-26 92.6 9.9 1.2e-15 57.1 6.2 2.2 2 0 0 2 2 2 2 Permease family Exo_endo_phos_2 PF14529.6 PIK59088.1 - 0.00022 21.0 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK59088.1 - 0.0021 17.6 0.0 0.0042 16.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TF_Zn_Ribbon PF08271.12 PIK59088.1 - 0.026 14.0 1.8 1.9 8.1 0.2 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding Xan_ur_permease PF00860.20 PIK59089.1 - 0.00017 20.4 0.1 0.00048 18.9 0.1 1.6 1 1 1 2 2 2 1 Permease family F5_F8_type_C PF00754.25 PIK59090.1 - 4.7e-14 52.6 3.4 9.2e-07 29.0 0.7 2.6 2 0 0 2 2 2 2 F5/8 type C domain EGF_CA PF07645.15 PIK59090.1 - 1.2e-07 31.8 7.1 4.4e-07 30.0 7.1 2.1 1 0 0 1 1 1 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK59090.1 - 1.7e-06 28.2 8.2 5.2e-06 26.6 8.2 1.9 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Lectin_C PF00059.21 PIK59090.1 - 0.00023 21.9 0.7 0.00023 21.9 0.7 3.7 3 2 1 4 4 3 1 Lectin C-type domain EGF PF00008.27 PIK59090.1 - 0.00048 20.4 7.3 0.0022 18.3 7.3 2.2 1 0 0 1 1 1 1 EGF-like domain cEGF PF12662.7 PIK59090.1 - 0.00091 19.1 2.4 0.0063 16.4 1.7 2.5 2 0 0 2 2 2 1 Complement Clr-like EGF-like BAR_3 PF16746.5 PIK59090.1 - 0.0048 16.6 2.9 0.0048 16.6 2.9 1.9 2 0 0 2 2 2 1 BAR domain of APPL family Colipase-like PF15083.6 PIK59090.1 - 0.052 13.7 7.9 0.24 11.6 7.9 2.2 1 0 0 1 1 1 0 Colipase-like EGF_3 PF12947.7 PIK59090.1 - 0.061 13.5 3.8 0.18 12.0 3.8 1.9 1 0 0 1 1 1 0 EGF domain Cor1 PF04803.12 PIK59090.1 - 0.13 12.5 6.8 0.54 10.5 6.7 2.1 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Apolipoprotein PF01442.18 PIK59090.1 - 0.16 11.9 0.0 0.24 11.3 0.0 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain APG17 PF04108.12 PIK59090.1 - 0.3 10.2 16.9 3.4 6.7 17.0 2.0 1 1 1 2 2 2 0 Autophagy protein Apg17 MAP65_ASE1 PF03999.12 PIK59090.1 - 0.53 8.9 7.3 0.75 8.4 7.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) His_Phos_2 PF00328.22 PIK59090.1 - 0.57 9.5 4.6 0.87 8.9 4.6 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DUF3150 PF11348.8 PIK59090.1 - 1.1 8.5 3.7 4.8 6.3 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3150) Phage_int_SAM_5 PF13102.6 PIK59090.1 - 3.2 8.1 17.8 83 3.6 4.6 3.9 1 1 1 2 2 2 0 Phage integrase SAM-like domain Phi-29_GP4 PF05464.11 PIK59090.1 - 4 7.7 8.7 29 5.0 0.4 3.4 1 1 1 3 3 3 0 Phi-29-like late genes activator (early protein GP4) Terminase_4 PF05119.12 PIK59090.1 - 5.1 7.6 4.7 71 3.9 1.3 3.1 1 1 1 2 2 2 0 Phage terminase, small subunit hEGF PF12661.7 PIK59090.1 - 6.2 7.6 10.3 2 9.2 5.8 2.8 2 0 0 2 2 1 0 Human growth factor-like EGF CUB PF00431.20 PIK59091.1 - 8.2e-29 100.2 0.1 4.6e-14 52.7 0.0 2.3 2 0 0 2 2 2 2 CUB domain Lectin_C PF00059.21 PIK59091.1 - 0.00013 22.7 0.3 0.00092 19.9 0.1 2.3 2 0 0 2 2 2 1 Lectin C-type domain CUB_2 PF02408.20 PIK59091.1 - 0.0073 16.1 0.6 0.066 13.0 0.1 2.3 2 0 0 2 2 2 1 CUB-like domain 7tm_1 PF00001.21 PIK59092.1 - 3.6e-23 82.2 18.7 4.7e-23 81.9 18.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 PIK59092.1 - 2.2e-09 36.9 0.8 4.7e-09 35.9 0.8 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 PIK59092.1 - 0.0021 18.4 0.7 0.0049 17.3 0.7 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK59092.1 - 0.033 14.2 1.1 0.058 13.4 1.1 1.4 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK59092.1 - 1.2 9.9 4.5 1.2 10.0 1.4 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat DUF751 PF05421.11 PIK59092.1 - 1.3 9.8 9.6 2.2 9.0 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF751) HYR PF02494.16 PIK59093.1 - 1.2e-56 189.0 5.2 1.2e-23 83.2 0.4 3.5 3 0 0 3 3 3 3 HYR domain UreE_C PF05194.12 PIK59093.1 - 0.12 12.9 7.9 0.22 12.0 7.9 1.4 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain Lamp PF01299.17 PIK59097.1 - 1.1e-05 25.3 2.1 1.8e-05 24.6 2.1 1.3 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 PIK59097.1 - 4.5e-05 23.3 0.6 8.2e-05 22.5 0.6 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) GCV_T PF01571.21 PIK59098.1 - 1e-71 241.4 0.0 1.3e-71 241.0 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 PIK59098.1 - 1.2e-11 44.3 0.0 2.4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 PIK59098.1 - 2.4e-05 24.5 0.0 4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family Hydrolase PF00702.26 PIK59098.1 - 0.087 13.1 0.0 0.25 11.6 0.0 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase COesterase PF00135.28 PIK59099.1 - 5.2e-60 203.8 0.0 5.8e-32 111.2 0.0 2.0 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK59099.1 - 0.041 13.7 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold COesterase PF00135.28 PIK59100.1 - 3.5e-83 280.2 0.0 4e-83 280.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK59100.1 - 0.00026 20.9 0.2 0.23 11.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 PIK59101.1 - 2e-46 158.9 0.0 2.4e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Dicer_N PF17895.1 PIK59101.1 - 0.033 14.0 0.0 0.81 9.5 0.0 2.2 2 0 0 2 2 2 0 Giardia Dicer N-terminal domain COesterase PF00135.28 PIK59102.1 - 1.5e-24 86.8 0.4 3.1e-24 85.7 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family UT PF03253.14 PIK59103.1 - 0.024 13.8 3.3 0.44 9.6 0.1 2.0 2 0 0 2 2 2 0 Urea transporter RhoGEF PF00621.20 PIK59104.1 - 5.8e-18 65.8 1.8 2.6e-17 63.7 0.2 2.3 2 0 0 2 2 2 1 RhoGEF domain PH_16 PF17838.1 PIK59104.1 - 0.0002 21.2 0.1 0.0016 18.3 0.0 2.3 2 0 0 2 2 2 1 PH domain DNA_pol3_tau_5 PF12170.8 PIK59106.1 - 0.17 11.9 2.3 2.9 7.9 0.4 2.1 2 0 0 2 2 2 0 DNA polymerase III tau subunit V interacting with alpha Carn_acyltransf PF00755.20 PIK59107.1 - 2e-88 297.5 0.0 2.7e-88 297.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase 7tm_2 PF00002.24 PIK59108.1 - 1.3e-26 93.4 26.0 4.2e-15 55.7 12.7 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) GAIN PF16489.5 PIK59108.1 - 0.002 17.6 0.8 0.014 14.8 0.3 2.2 2 0 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain DUF1405 PF07187.11 PIK59108.1 - 0.77 9.7 7.9 1.4 8.9 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1405) Carn_acyltransf PF00755.20 PIK59109.1 - 5.2e-144 481.1 0.0 6.4e-144 480.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Ribosomal_L21e PF01157.18 PIK59109.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L21e Carn_acyltransf PF00755.20 PIK59110.1 - 7.1e-159 530.2 0.0 8e-159 530.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF1589 PF07628.11 PIK59110.1 - 0.17 12.0 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1589) RVT_1 PF00078.27 PIK59112.1 - 0.0027 17.2 0.0 0.0049 16.4 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5641 PF18701.1 PIK59113.1 - 1.5e-30 105.2 3.4 2.3e-30 104.6 3.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK59113.1 - 1.2e-05 25.5 0.0 1.9e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain 7tm_2 PF00002.24 PIK59114.1 - 1.3e-21 77.0 18.1 7.8e-13 48.3 5.9 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK59114.1 - 7.3e-16 58.4 0.3 1.4e-15 57.5 0.3 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif FAM176 PF14851.6 PIK59114.1 - 0.093 12.4 0.7 2.3 7.9 0.0 2.9 3 0 0 3 3 3 0 FAM176 family TraL PF07178.11 PIK59114.1 - 0.11 13.0 0.1 0.11 13.0 0.1 3.1 2 1 1 3 3 3 0 TraL protein ECSCR PF15820.5 PIK59114.1 - 0.14 12.0 0.2 0.14 12.0 0.2 3.2 2 1 1 3 3 3 0 Endothelial cell-specific chemotaxis regulator PRIMA1 PF16101.5 PIK59114.1 - 0.35 10.9 4.0 3.7 7.6 0.6 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 PMT_4TMC PF16192.5 PIK59114.1 - 0.82 9.2 6.9 3 7.4 2.0 2.2 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase DUF3810 PF12725.7 PIK59114.1 - 5.1 6.4 8.5 1.9 7.7 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) EphA2_TM PF14575.6 PIK59114.1 - 5.8 7.9 7.9 17 6.3 0.1 3.1 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Wzy_C PF04932.15 PIK59114.1 - 9.2 5.9 8.8 15 5.2 7.8 1.9 1 1 0 1 1 1 0 O-Antigen ligase GAIN PF16489.5 PIK59115.1 - 0.0028 17.1 0.3 0.0055 16.2 0.3 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Carn_acyltransf PF00755.20 PIK59116.1 - 3.2e-116 389.3 0.0 5.7e-116 388.5 0.0 1.3 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 PIK59118.1 - 5.9e-05 22.1 19.8 0.00041 19.4 21.0 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Tubulin_C PF03953.17 PIK59119.1 - 4.7e-52 175.4 0.0 6.3e-52 175.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Sec2p PF06428.11 PIK59119.1 - 0.038 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Tubulin PF00091.25 PIK59120.1 - 3.2e-33 115.6 0.0 3.9e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain SRCR PF00530.18 PIK59121.1 - 1.3e-25 89.8 10.4 5.6e-21 74.9 3.1 3.1 2 1 1 3 3 3 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK59121.1 - 1.4e-07 32.0 0.3 3.4e-07 30.7 0.3 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Saf_2TM PF18303.1 PIK59121.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Hepsin-SRCR PF09272.10 PIK59121.1 - 0.019 15.5 0.1 0.041 14.4 0.1 1.6 1 0 0 1 1 1 0 Hepsin, SRCR domain FtsL PF04999.13 PIK59121.1 - 0.025 14.5 0.1 0.042 13.9 0.1 1.3 1 0 0 1 1 1 0 Cell division protein FtsL DUF1129 PF06570.11 PIK59121.1 - 0.028 13.9 0.5 0.043 13.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) 7TM_GPCR_Srab PF10292.9 PIK59121.1 - 0.051 12.5 0.0 0.079 11.9 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Sushi PF00084.20 PIK59121.1 - 0.13 12.9 1.6 0.24 12.1 0.1 2.3 2 0 0 2 2 2 0 Sushi repeat (SCR repeat) DnaJ_C PF01556.18 PIK59123.1 - 6.7e-30 104.1 0.0 9.4e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 PIK59123.1 - 4.7e-22 77.9 1.0 7e-22 77.3 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain Peptidase_C48 PF02902.19 PIK59124.1 - 2.3e-28 99.6 2.2 7.5e-28 97.8 2.2 1.9 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain UCH PF00443.29 PIK59124.1 - 1.5e-17 63.9 1.8 4.3e-17 62.5 0.7 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK59124.1 - 9.9e-09 35.2 2.4 9.9e-09 35.2 2.4 2.3 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase PHD PF00628.29 PIK59124.1 - 2.4e-05 24.1 9.0 2.4e-05 24.1 9.0 3.3 3 0 0 3 3 3 1 PHD-finger TMEM131_like PF12371.8 PIK59125.1 - 0.045 14.0 0.2 3.4 8.0 0.0 2.8 2 1 0 2 2 2 0 Transmembrane protein 131-like Motile_Sperm PF00635.26 PIK59125.1 - 0.057 13.3 4.1 0.24 11.2 0.6 3.1 3 1 0 3 3 3 0 MSP (Major sperm protein) domain Transglut_C PF00927.22 PIK59125.1 - 0.23 11.6 1.3 1.2 9.3 0.1 2.7 3 1 0 4 4 4 0 Transglutaminase family, C-terminal ig like domain ASH PF15780.5 PIK59126.1 - 1.1e-10 41.6 1.7 0.15 12.3 0.0 6.6 6 1 0 6 6 6 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CH PF00307.31 PIK59126.1 - 8.4e-08 32.4 0.0 3.3e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Calponin homology (CH) domain Motile_Sperm PF00635.26 PIK59126.1 - 0.00017 21.4 0.0 3 7.7 0.0 3.6 3 0 0 3 3 3 2 MSP (Major sperm protein) domain PapD-like PF14874.6 PIK59126.1 - 0.0012 19.0 1.5 3.2 8.0 0.1 4.9 5 0 0 5 5 5 1 Flagellar-associated PapD-like CAMSAP_CH PF11971.8 PIK59126.1 - 0.15 11.9 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain DUF1573 PF07610.11 PIK59126.1 - 0.16 12.0 0.0 31 4.7 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 PIK59127.1 - 2.2e-08 34.3 2.5 0.00019 21.6 0.1 4.3 5 0 0 5 5 5 2 Transmembrane protein 131-like ASH PF15780.5 PIK59127.1 - 2.2e-08 34.2 3.0 0.00065 19.9 0.1 6.1 6 0 0 6 6 6 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Transglut_C PF00927.22 PIK59127.1 - 4.1e-05 23.7 0.5 0.25 11.5 0.0 5.0 4 1 0 4 4 4 1 Transglutaminase family, C-terminal ig like domain TFIID-18kDa PF02269.16 PIK59129.1 - 2.8e-14 52.9 0.0 6.6e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Runt PF00853.19 PIK59130.1 - 2.8e-68 227.4 0.0 3.5e-68 227.1 0.0 1.1 1 0 0 1 1 1 1 Runt domain ATE_C PF04377.15 PIK59131.1 - 2.6e-31 109.0 0.8 4.8e-31 108.2 0.8 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 PIK59131.1 - 2.3e-12 47.1 1.2 1.2e-11 44.9 1.2 2.2 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 PIK59131.1 - 0.091 12.9 0.1 0.19 11.9 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PDZ PF00595.24 PIK59132.1 - 0.0001 22.6 0.0 0.00026 21.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 PIK59132.1 - 0.00017 22.1 5.4 0.0034 17.9 2.4 3.1 3 0 0 3 3 3 1 PH domain PDZ_6 PF17820.1 PIK59132.1 - 0.0056 16.5 0.1 0.016 15.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 PIK59132.1 - 0.47 10.9 2.6 1.9 9.0 2.6 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain PH PF00169.29 PIK59133.1 - 0.0043 17.5 0.2 0.0062 17.0 0.2 1.3 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 PIK59133.1 - 0.067 13.0 0.6 0.078 12.8 0.6 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain Cupin_8 PF13621.6 PIK59134.1 - 1.5e-33 116.6 0.1 5.4e-33 114.8 0.1 2.0 1 1 0 1 1 1 1 Cupin-like domain EF-hand_7 PF13499.6 PIK59134.1 - 0.0016 18.9 1.2 0.032 14.7 0.5 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK59134.1 - 0.013 15.0 0.2 0.17 11.5 0.1 2.7 2 0 0 2 2 2 0 EF hand JmjC PF02373.22 PIK59134.1 - 0.014 15.9 0.1 0.05 14.0 0.1 2.0 1 0 0 1 1 1 0 JmjC domain, hydroxylase EF-hand_6 PF13405.6 PIK59134.1 - 0.025 14.5 0.6 0.74 9.9 0.1 3.1 3 0 0 3 3 3 0 EF-hand domain Dynein_C PF18199.1 PIK59135.1 - 3.8e-63 213.5 0.2 1.1e-34 120.1 0.0 2.0 2 0 0 2 2 2 2 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 PIK59136.1 - 4.3e-82 274.5 0.4 3.5e-81 271.5 0.6 2.3 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 PIK59136.1 - 3.9e-56 189.4 0.0 8.7e-56 188.3 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 PIK59136.1 - 7.4e-44 150.2 6.9 7.4e-44 150.2 6.9 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.7 PIK59136.1 - 7.1e-38 130.4 0.0 6.2e-37 127.3 0.0 2.3 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_heavy PF03028.15 PIK59136.1 - 2.3e-29 101.9 0.0 1.9e-28 98.9 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_C PF18199.1 PIK59136.1 - 0.0003 20.1 0.0 0.0003 20.1 0.0 2.7 4 0 0 4 4 4 1 Dynein heavy chain C-terminal domain IF2_N PF04760.15 PIK59136.1 - 0.013 15.3 1.0 0.32 10.8 0.5 3.1 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region Tobravirus_2B PF05271.11 PIK59136.1 - 0.03 14.2 0.0 0.086 12.8 0.0 1.8 1 0 0 1 1 1 0 Tobravirus 2B protein Fez1 PF06818.15 PIK59136.1 - 0.35 11.3 18.0 0.15 12.5 0.2 3.2 3 0 0 3 3 3 0 Fez1 WEMBL PF05701.11 PIK59136.1 - 7.2 5.2 32.4 0.36 9.5 1.0 3.1 3 0 0 3 3 3 0 Weak chloroplast movement under blue light AAA_6 PF12774.7 PIK59137.1 - 2.3e-144 480.3 0.0 3.2e-143 476.6 0.0 2.6 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 PIK59137.1 - 4.5e-117 392.0 10.8 7.2e-74 249.4 5.2 3.5 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 PIK59137.1 - 1.4e-109 366.9 3.2 1.4e-109 366.9 3.2 4.4 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 PIK59137.1 - 2.9e-69 232.2 0.8 1.4e-63 213.7 0.1 4.2 4 0 0 4 4 4 3 P-loop containing dynein motor region AAA_8 PF12780.7 PIK59137.1 - 3.7e-29 101.8 0.1 9.7e-29 100.5 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 PIK59137.1 - 1.4e-22 80.2 0.0 3.6e-07 30.2 0.0 5.3 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 PIK59137.1 - 8.7e-18 64.7 6.6 9.2e-18 64.6 0.1 3.4 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 PIK59137.1 - 1e-14 54.5 0.1 5.5e-14 52.2 0.1 2.3 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 PIK59137.1 - 2.4e-07 31.3 0.1 0.42 11.0 0.0 4.5 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK59137.1 - 0.0073 16.6 4.8 17 5.7 0.0 4.7 5 0 0 5 5 5 0 AAA domain AAA_30 PF13604.6 PIK59137.1 - 0.0097 15.6 2.4 27 4.4 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_18 PF13238.6 PIK59137.1 - 0.053 14.1 1.1 15 6.2 0.0 4.7 5 0 0 5 5 5 0 AAA domain Sipho_Gp157 PF05565.11 PIK59137.1 - 0.075 13.0 1.8 0.65 10.0 0.1 2.9 2 0 0 2 2 2 0 Siphovirus Gp157 Sigma54_activat PF00158.26 PIK59137.1 - 0.084 12.6 0.4 4.2 7.0 0.0 3.3 4 0 0 4 4 4 0 Sigma-54 interaction domain AAA_33 PF13671.6 PIK59137.1 - 0.5 10.5 5.0 15 5.8 0.0 4.5 6 0 0 6 6 5 0 AAA domain DHC_N1 PF08385.12 PIK59138.1 - 1.1e-19 70.6 0.3 2e-19 69.7 0.3 1.5 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 L_protein_N PF15518.6 PIK59138.1 - 0.017 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 L protein N-terminus SH3_9 PF14604.6 PIK59139.1 - 1.6e-19 69.5 3.0 9.6e-13 47.8 0.2 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 PIK59139.1 - 7.3e-17 60.8 0.9 2e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK59139.1 - 8.9e-15 54.0 5.1 1.9e-10 40.1 0.1 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 PIK59140.1 - 2.3e-13 49.7 0.0 3.4e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK59140.1 - 3.9e-13 48.9 0.0 5.9e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK59140.1 - 1.5e-11 43.7 0.5 2.3e-11 43.1 0.5 1.3 1 0 0 1 1 1 1 SH3 domain Tmemb_cc2 PF10267.9 PIK59140.1 - 0.0017 17.6 0.1 0.0021 17.3 0.1 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Rootletin PF15035.6 PIK59140.1 - 0.0028 17.7 4.4 0.004 17.2 4.4 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF1664 PF07889.12 PIK59140.1 - 0.004 17.2 6.0 0.0067 16.5 6.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 PIK59140.1 - 0.02 14.4 5.1 0.026 14.0 5.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 PIK59140.1 - 0.021 14.2 0.2 0.03 13.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1319 PF07028.11 PIK59140.1 - 0.057 13.6 1.8 0.1 12.8 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Com_YlbF PF06133.11 PIK59140.1 - 0.067 13.8 5.2 0.1 13.2 5.2 1.2 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Baculo_PEP_C PF04513.12 PIK59140.1 - 0.082 12.9 0.2 0.11 12.5 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lzipper-MIP1 PF14389.6 PIK59140.1 - 0.3 11.4 4.5 0.43 10.9 2.8 2.0 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CARMIL_C PF16000.5 PIK59140.1 - 0.4 10.3 13.3 0.03 14.0 8.3 1.6 2 0 0 2 2 2 0 CARMIL C-terminus HIP1_clath_bdg PF16515.5 PIK59140.1 - 0.42 11.3 7.9 0.91 10.2 7.9 1.6 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 COMP PF11598.8 PIK59140.1 - 0.43 11.1 0.1 0.43 11.1 0.1 1.9 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein FlaC_arch PF05377.11 PIK59140.1 - 0.44 11.0 5.2 0.61 10.5 4.3 1.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1515 PF07439.11 PIK59140.1 - 0.55 10.3 3.9 0.86 9.7 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DivIC PF04977.15 PIK59140.1 - 1.2 9.0 5.9 0.76 9.6 0.8 2.2 1 1 1 2 2 2 0 Septum formation initiator Ribosomal_L29 PF00831.23 PIK59140.1 - 2.3 8.3 6.5 1.2 9.1 1.4 2.2 1 1 1 2 2 2 0 Ribosomal L29 protein Cnn_1N PF07989.11 PIK59140.1 - 3 8.1 9.5 1 9.6 1.5 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DEAD PF00270.29 PIK59141.1 - 2.3e-46 157.8 0.2 5.3e-46 156.6 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK59141.1 - 7.7e-25 87.4 0.1 8.3e-24 84.1 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 PIK59141.1 - 3.7e-18 65.5 0.2 6.8e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 PIK59141.1 - 3.5e-07 30.4 0.9 9.8e-07 28.9 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 PIK59141.1 - 0.11 12.8 1.4 0.78 10.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain Tubulin_C PF03953.17 PIK59142.1 - 2.7e-51 173.0 0.0 3.6e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 PIK59143.1 - 4.6e-50 170.5 0.0 5.2e-50 170.4 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 PIK59143.1 - 0.0015 18.2 0.0 0.0031 17.2 0.0 1.4 1 1 0 1 1 1 1 Tubulin domain RRM_1 PF00076.22 PIK59144.1 - 5.2e-18 64.6 0.0 1.3e-08 34.5 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK59144.1 - 0.084 12.7 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif Vg_Tdu PF07545.14 PIK59145.1 - 2.5e-15 55.9 0.2 5.9e-15 54.7 0.2 1.7 1 0 0 1 1 1 1 Vestigial/Tondu family FAM181 PF15238.6 PIK59145.1 - 0.071 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 FAM181 Acetyltransf_1 PF00583.25 PIK59146.1 - 0.00016 21.9 0.0 0.22 11.8 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Gal_Lectin PF02140.18 PIK59147.1 - 6.3e-27 93.8 8.3 3.8e-18 65.7 1.9 4.4 3 2 1 4 4 4 2 Galactose binding lectin domain TIL PF01826.17 PIK59147.1 - 3.1e-08 33.8 18.7 3.1e-08 33.8 18.7 5.7 4 2 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK59147.1 - 4.8e-08 32.8 12.4 4.8e-08 32.8 12.4 4.2 3 1 0 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK59147.1 - 3.2e-05 24.0 5.0 3.2e-05 24.0 5.0 4.6 4 1 0 4 4 4 1 EGF domain VWD PF00094.25 PIK59148.1 - 3e-73 245.3 0.0 1.9e-29 103.0 0.0 3.4 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 PIK59148.1 - 2e-26 92.2 13.8 6e-16 58.6 5.7 5.5 4 1 1 5 5 5 2 C8 domain F5_F8_type_C PF00754.25 PIK59148.1 - 1.3e-18 67.3 0.0 2.6e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain Gal_Lectin PF02140.18 PIK59148.1 - 3e-18 66.0 7.5 2e-13 50.5 0.5 7.3 8 2 0 9 9 9 2 Galactose binding lectin domain TIL PF01826.17 PIK59148.1 - 3.1e-16 59.3 39.0 6.8e-12 45.4 19.1 9.7 9 2 1 10 10 10 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK59148.1 - 3.2e-11 43.0 21.4 5.9e-08 32.5 6.7 6.6 5 2 2 7 7 7 2 TILa domain EGF PF00008.27 PIK59148.1 - 8.7e-07 29.1 6.2 8.7e-07 29.1 6.2 7.9 7 1 0 7 7 7 2 EGF-like domain COLFI PF01410.18 PIK59149.1 - 1.2e-10 41.1 2.9 2.3e-07 30.3 0.0 4.9 3 3 1 4 4 4 2 Fibrillar collagen C-terminal domain Fibrinogen_C PF00147.18 PIK59149.1 - 4.9e-05 23.2 2.6 0.0005 20.0 0.0 2.7 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain Glyco_hyd_101C PF17451.2 PIK59150.1 - 0.2 12.0 0.0 0.62 10.4 0.0 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Tcp10_C PF07202.13 PIK59151.1 - 8.8e-07 29.0 0.1 0.27 11.2 0.0 4.8 2 1 0 3 3 3 2 T-complex protein 10 C-terminus Poly_export PF02563.16 PIK59151.1 - 0.028 14.6 4.1 24 5.2 0.1 5.7 3 3 0 3 3 3 0 Polysaccharide biosynthesis/export protein Big_11 PF18200.1 PIK59151.1 - 0.029 14.3 9.7 3.9 7.4 0.4 5.5 3 3 2 5 5 5 0 Bacterial Ig-like domain VirK PF06903.12 PIK59151.1 - 0.16 12.1 0.1 8.6 6.5 0.0 3.2 1 1 2 3 3 3 0 VirK protein Cuticle_1 PF08140.11 PIK59151.1 - 0.81 9.8 19.0 2.1 8.4 0.0 8.7 9 3 1 10 10 10 0 Crustacean cuticle protein repeat DUF1387 PF07139.11 PIK59152.1 - 0.006 16.4 47.0 0.011 15.5 16.6 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1387) zf-CRD PF17979.1 PIK59152.1 - 0.0073 16.4 0.6 0.014 15.5 0.6 1.4 1 0 0 1 1 1 1 Cysteine rich domain with multizinc binding regions MscS_TM PF12794.7 PIK59152.1 - 0.0081 15.1 5.5 0.0081 15.1 5.5 4.1 4 0 0 4 4 4 2 Mechanosensitive ion channel inner membrane domain 1 FYDLN_acid PF09538.10 PIK59152.1 - 0.036 14.8 5.1 0.036 14.8 5.1 4.2 2 2 2 4 4 4 0 Protein of unknown function (FYDLN_acid) Presenilin PF01080.17 PIK59152.1 - 0.076 11.8 39.5 0.074 11.8 15.8 2.1 2 0 0 2 2 2 0 Presenilin TFIIA PF03153.13 PIK59152.1 - 0.19 11.7 49.1 0.22 11.5 13.6 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAS_3 PF08447.12 PIK59153.1 - 3.2e-25 88.2 0.1 2.8e-19 69.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 PIK59153.1 - 3.8e-24 85.0 0.1 2e-17 63.3 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 PIK59153.1 - 1.6e-16 60.3 0.0 2e-11 43.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK59153.1 - 6.1e-05 23.2 0.0 0.028 14.7 0.0 2.6 2 0 0 2 2 2 2 PAS domain HLH PF00010.26 PIK59153.1 - 0.0005 20.0 0.8 0.0009 19.1 0.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.10 PIK59153.1 - 0.0047 17.2 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 1 PAS fold CDC45 PF02724.14 PIK59153.1 - 0.028 12.7 3.3 0.048 12.0 3.3 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 PIK59153.1 - 6.8 6.0 21.8 0.21 11.0 14.5 1.8 2 0 0 2 2 2 0 SDA1 WD40 PF00400.32 PIK59155.1 - 4.7e-24 84.2 9.8 6.2e-07 30.0 0.2 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat TPR_11 PF13414.6 PIK59155.1 - 1.9e-07 30.6 0.4 2.5e-06 27.1 0.1 2.2 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 PIK59155.1 - 3.8e-07 30.5 0.2 0.028 14.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK59155.1 - 1.9e-05 25.1 0.5 0.16 12.8 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 PIK59155.1 - 4.1e-05 23.8 0.0 0.011 16.1 0.0 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_1 PF00515.28 PIK59155.1 - 7.1e-05 22.4 1.0 0.24 11.3 0.0 3.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK59155.1 - 0.0032 17.5 3.3 0.51 10.6 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK59155.1 - 0.025 15.0 0.0 0.1 13.0 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK59155.1 - 0.1 12.8 0.1 1.7 9.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK59155.1 - 0.13 12.4 0.7 0.28 11.3 0.7 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Kunitz_BPTI PF00014.23 PIK59156.1 - 1.3e-17 63.7 2.2 2.4e-17 62.9 2.2 1.5 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain SET PF00856.28 PIK59157.1 - 2.9e-09 37.5 0.1 2.9e-09 37.5 0.1 5.5 3 2 0 3 3 3 1 SET domain WW PF00397.26 PIK59158.1 - 1.1e-06 28.6 0.2 2.1e-06 27.7 0.2 1.5 1 0 0 1 1 1 1 WW domain p450 PF00067.22 PIK59159.1 - 1.5e-51 175.6 0.0 5.1e-51 173.9 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF664 PF04978.12 PIK59159.1 - 0.0042 17.5 0.9 0.0085 16.5 0.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF664) p450 PF00067.22 PIK59160.1 - 5.5e-06 25.4 0.1 6e-06 25.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_4 PF12799.7 PIK59161.1 - 2.4e-33 113.6 69.9 1.1e-08 35.2 7.0 7.2 3 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK59161.1 - 1.1e-21 77.2 25.6 2.7e-08 33.5 8.4 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 PIK59161.1 - 1.4e-19 69.6 76.4 6.7e-06 25.8 1.0 6.2 1 1 5 8 8 8 7 Leucine rich repeat LRR_6 PF13516.6 PIK59161.1 - 1.8e-05 24.4 20.9 0.25 11.5 0.0 7.5 8 0 0 8 8 8 3 Leucine Rich repeat Phage_rep_org_N PF09681.10 PIK59161.1 - 0.0048 16.8 7.3 2.3 8.2 0.3 3.5 1 1 2 3 3 3 2 N-terminal phage replisome organiser (Phage_rep_org_N) Ribosomal_L50 PF10501.9 PIK59161.1 - 0.009 16.1 0.7 3 8.0 0.1 3.0 1 1 2 3 3 3 1 Ribosomal subunit 39S MannoseP_isomer PF01050.18 PIK59161.1 - 0.044 13.7 0.1 0.15 12.0 0.0 1.8 1 1 1 2 2 2 0 Mannose-6-phosphate isomerase LRR_1 PF00560.33 PIK59161.1 - 0.054 14.0 29.9 3.6 8.5 0.2 9.0 9 2 0 9 9 9 0 Leucine Rich Repeat Orthopox_F6 PF06601.12 PIK59161.1 - 1 9.5 6.2 0.33 11.1 1.9 2.5 2 2 1 3 3 3 0 Orthopoxvirus F6 protein GMP_synt_C PF00958.22 PIK59162.1 - 1e-19 70.3 0.0 4.7e-11 42.6 0.0 3.2 2 1 0 2 2 2 2 GMP synthase C terminal domain GATase PF00117.28 PIK59162.1 - 7.4e-11 42.2 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 PIK59162.1 - 1.3e-10 40.8 0.1 1.3e-06 27.7 0.1 2.4 2 0 0 2 2 2 2 NAD synthase QueC PF06508.13 PIK59162.1 - 5.2e-07 29.4 0.0 5.7e-06 26.0 0.0 2.3 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 PIK59162.1 - 1.4e-05 24.0 0.0 0.00011 21.1 0.0 2.1 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.21 PIK59162.1 - 5.9e-05 22.9 0.1 0.00011 22.0 0.1 1.3 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 PIK59162.1 - 8.9e-05 22.2 0.1 0.00047 19.8 0.1 2.1 2 1 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) Peptidase_C26 PF07722.13 PIK59162.1 - 0.0004 20.2 0.0 0.00067 19.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 Arginosuc_synth PF00764.19 PIK59162.1 - 0.0009 18.6 0.2 0.005 16.2 0.1 1.9 2 0 0 2 2 2 1 Arginosuccinate synthase PAPS_reduct PF01507.19 PIK59162.1 - 0.0016 18.6 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 PIK59162.1 - 0.0026 17.5 0.2 0.0064 16.3 0.1 1.7 2 0 0 2 2 2 1 PP-loop family ArnB_C PF18677.1 PIK59162.1 - 0.035 14.2 1.2 4.3 7.5 0.5 2.4 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain NPV_P10 PF05531.12 PIK59162.1 - 0.14 12.6 0.1 0.47 11.0 0.1 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RPE65 PF03055.15 PIK59163.1 - 5.1e-121 405.1 0.2 6e-121 404.9 0.2 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF1104 PF06518.11 PIK59164.1 - 0.026 14.9 1.5 0.026 14.9 1.5 10.0 4 2 5 9 9 9 0 Protein of unknown function (DUF1104) Transglut_core PF01841.19 PIK59165.1 - 0.16 12.4 0.0 0.44 11.0 0.0 1.7 2 0 0 2 2 2 0 Transglutaminase-like superfamily CDC37_N PF03234.14 PIK59165.1 - 0.4 11.6 7.5 0.17 12.8 4.3 1.9 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding XhlA PF10779.9 PIK59165.1 - 9.2 6.6 8.5 4.7 7.5 0.1 3.0 3 0 0 3 3 3 0 Haemolysin XhlA RVT_1 PF00078.27 PIK59167.1 - 6e-23 81.5 0.1 7e-23 81.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DivIC PF04977.15 PIK59168.1 - 0.00021 21.0 3.8 0.00021 21.0 3.8 1.9 1 1 1 2 2 2 1 Septum formation initiator DUF4686 PF15742.5 PIK59168.1 - 0.0025 17.0 8.4 0.048 12.8 8.6 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4686) Herpes_UL14 PF03580.14 PIK59168.1 - 0.098 12.9 3.9 0.072 13.3 2.3 1.5 1 1 0 1 1 1 0 Herpesvirus UL14-like protein DHR10 PF18595.1 PIK59168.1 - 0.37 10.9 10.2 2.4 8.2 1.6 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain betaPIX_CC PF16523.5 PIK59168.1 - 0.54 10.1 7.2 0.84 9.5 7.2 1.2 1 0 0 1 1 1 0 betaPIX coiled coil Phage_Gp23 PF10669.9 PIK59168.1 - 1.2 9.5 9.0 1.7 9.0 9.0 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Prominin PF05478.11 PIK59168.1 - 7.1 4.5 7.5 8.3 4.2 7.5 1.0 1 0 0 1 1 1 0 Prominin SWIRM-assoc_1 PF16495.5 PIK59168.1 - 9.1 6.3 12.1 5.5 7.0 4.1 2.1 1 1 1 2 2 2 0 SWIRM-associated region 1 ATG16 PF08614.11 PIK59169.1 - 0.001 19.3 21.0 0.001 19.3 21.0 5.7 1 1 5 6 6 6 1 Autophagy protein 16 (ATG16) ABC_membrane_2 PF06472.15 PIK59169.1 - 0.1 12.0 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Filament PF00038.21 PIK59169.1 - 0.88 9.1 78.3 0.018 14.6 17.6 4.0 1 1 2 3 3 3 0 Intermediate filament protein FOP_dimer PF09398.10 PIK59169.1 - 2.1 8.7 7.9 1.5 9.1 0.1 3.6 3 0 0 3 3 3 0 FOP N terminal dimerisation domain DUF572 PF04502.13 PIK59170.1 - 0.055 13.1 12.8 0.069 12.8 12.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) BST2 PF16716.5 PIK59170.1 - 1.1 9.9 13.4 1.7 9.3 5.0 2.4 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF5499 PF17603.2 PIK59170.1 - 2.5 8.8 6.2 6 7.5 1.7 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5499) OSTbeta PF15048.6 PIK59171.1 - 0.0011 19.0 0.3 0.0019 18.3 0.3 1.3 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein Phage_holin_3_6 PF07332.11 PIK59171.1 - 0.011 15.7 0.1 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Vpu PF00558.19 PIK59171.1 - 0.016 14.9 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 Vpu protein 7tm_7 PF08395.12 PIK59171.1 - 0.024 13.9 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor Shisa PF13908.6 PIK59171.1 - 0.043 14.1 0.2 0.061 13.6 0.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PgaD PF13994.6 PIK59171.1 - 0.064 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 PgaD-like protein DUF4834 PF16118.5 PIK59171.1 - 0.07 14.1 2.3 0.16 12.9 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 PIK59171.1 - 0.074 13.9 1.0 0.16 12.9 1.0 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ASFV_J13L PF05568.11 PIK59171.1 - 0.082 12.7 0.4 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF1218 PF06749.12 PIK59171.1 - 0.099 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) ECSCR PF15820.5 PIK59171.1 - 0.12 12.2 0.7 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Glycoprotein_G PF00802.19 PIK59171.1 - 0.72 9.2 5.3 0.097 12.0 1.3 1.6 2 0 0 2 2 2 0 Pneumovirus attachment glycoprotein G RNA_pol_Rpb4 PF03874.16 PIK59172.1 - 1e-15 58.2 0.4 1e-15 58.1 0.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 Forkhead PF00250.18 PIK59173.1 - 3.1e-38 129.9 0.2 5.2e-38 129.2 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain Mitofilin PF09731.9 PIK59173.1 - 0.052 12.4 3.1 0.069 12.0 3.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF3464 PF11947.8 PIK59173.1 - 5.4 6.7 5.3 2.3 7.9 2.9 1.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 6PGD PF00393.19 PIK59174.1 - 6.2e-132 439.3 0.0 9.3e-132 438.7 0.0 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 PIK59174.1 - 4.1e-43 147.3 0.1 5.9e-43 146.8 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 PIK59174.1 - 0.0012 19.1 0.1 0.0093 16.2 0.1 2.4 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 PIK59174.1 - 0.024 15.2 0.3 0.056 14.0 0.3 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Ub-Mut7C PF14451.6 PIK59174.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Mut7-C ubiquitin DUF1617 PF07761.12 PIK59174.1 - 0.24 11.5 1.0 2.6 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1617) Cupin_8 PF13621.6 PIK59175.1 - 6e-32 111.3 0.0 1.5e-31 110.1 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK59175.1 - 0.0023 17.4 0.1 0.0052 16.3 0.0 1.8 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 PIK59175.1 - 0.02 14.6 0.0 0.051 13.3 0.0 1.7 1 0 0 1 1 1 0 Cupin domain JmjC PF02373.22 PIK59175.1 - 0.038 14.4 0.0 0.096 13.1 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_8 PF13621.6 PIK59176.1 - 2.1e-31 109.5 0.0 5.5e-31 108.2 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 PIK59176.1 - 2.2e-05 24.1 0.2 3.7e-05 23.3 0.2 1.4 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 PIK59176.1 - 0.02 15.3 0.0 0.04 14.4 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase BK_channel_a PF03493.18 PIK59177.1 - 7.6e-26 90.2 0.1 2.7e-25 88.4 0.0 2.0 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 PIK59177.1 - 5.4e-08 32.7 6.3 1.2e-07 31.6 6.3 1.6 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 PIK59177.1 - 0.00014 22.1 0.0 0.021 15.1 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain Ion_trans PF00520.31 PIK59177.1 - 0.023 13.9 3.6 0.043 13.0 3.6 1.3 1 0 0 1 1 1 0 Ion transport protein adh_short PF00106.25 PIK59178.1 - 7.9e-21 74.4 0.0 1.6e-14 53.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 PIK59178.1 - 2.3e-15 56.8 0.0 2.5e-11 43.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK59178.1 - 0.00023 21.1 0.0 0.00056 19.9 0.0 1.7 2 0 0 2 2 2 1 KR domain Methyltransf_25 PF13649.6 PIK59179.1 - 7.1e-16 58.7 0.0 3.5e-10 40.5 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 PIK59179.1 - 9.9e-13 48.6 0.0 1.4e-10 41.7 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59179.1 - 1.2e-10 41.4 1.3 3.1e-08 33.5 0.1 2.7 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59179.1 - 1.2e-05 25.9 0.1 0.0015 19.2 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Spermine_synth PF01564.17 PIK59179.1 - 4.3e-05 23.0 0.4 0.00011 21.6 0.3 1.8 2 0 0 2 2 2 1 Spermine/spermidine synthase domain MTS PF05175.14 PIK59179.1 - 0.0025 17.4 0.0 1.2 8.7 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase small domain Ubie_methyltran PF01209.18 PIK59179.1 - 0.091 12.1 0.8 2.5 7.4 0.1 2.5 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 PIK59179.1 - 0.11 11.9 0.3 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Trypsin PF00089.26 PIK59180.1 - 4.8e-50 170.4 0.0 7.3e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin Sushi PF00084.20 PIK59180.1 - 8.8e-11 42.2 19.8 0.00027 21.5 0.2 4.6 3 1 1 4 4 4 3 Sushi repeat (SCR repeat) DUF1986 PF09342.11 PIK59180.1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Sushi_2 PF09014.10 PIK59180.1 - 0.48 10.3 4.1 5 7.1 0.1 3.1 2 1 0 3 3 3 0 Beta-2-glycoprotein-1 fifth domain NDUF_B7 PF05676.13 PIK59180.1 - 4.7 7.0 5.6 1.3 8.8 0.2 2.8 3 1 0 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Tfb2 PF03849.14 PIK59181.1 - 7.4e-78 262.0 0.0 8.4e-78 261.8 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 DUF4817 PF16087.5 PIK59182.1 - 0.37 10.6 1.2 9.8 6.1 0.4 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) Glyco_transf_10 PF00852.19 PIK59183.1 - 1.4e-56 191.0 3.3 1.7e-56 190.8 3.3 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59183.1 - 0.037 14.5 1.6 0.068 13.6 0.2 2.1 2 0 0 2 2 2 0 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59184.1 - 2.7e-54 183.6 4.0 3.2e-54 183.3 4.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59184.1 - 0.038 14.4 1.6 0.068 13.6 0.2 2.1 2 0 0 2 2 2 0 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59185.1 - 4.3e-27 95.0 0.1 5.2e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59185.1 - 0.012 16.0 0.2 0.028 14.9 0.2 1.6 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal RabGAP-TBC PF00566.18 PIK59186.1 - 4.3e-37 127.9 0.9 5e-35 121.1 0.0 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Dimerisation2 PF16864.5 PIK59186.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain OST-HTH PF12872.7 PIK59187.1 - 4.2e-33 113.0 0.1 3.5e-08 33.1 0.0 4.4 4 0 0 4 4 4 4 OST-HTH/LOTUS domain TUDOR PF00567.24 PIK59187.1 - 2.6e-22 79.1 0.1 5.8e-22 78.0 0.1 1.6 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 PIK59187.1 - 0.075 13.5 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 Agenet domain RPA_C PF08784.11 PIK59188.1 - 0.034 14.8 0.5 0.043 14.5 0.5 1.1 1 0 0 1 1 1 0 Replication protein A C terminal DUF4706 PF15797.5 PIK59188.1 - 0.048 14.2 0.3 0.058 13.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) SRP-alpha_N PF04086.13 PIK59189.1 - 1.4e-52 179.5 14.5 1.7e-52 179.2 14.5 1.0 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal Longin PF13774.6 PIK59189.1 - 0.078 13.0 0.3 0.15 12.1 0.3 1.5 1 1 0 1 1 1 0 Regulated-SNARE-like domain SRP54 PF00448.22 PIK59190.1 - 3.7e-23 82.2 0.0 7.2e-22 78.0 0.0 2.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 PIK59190.1 - 3.1e-07 30.5 0.0 7.1e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain PPI_Ypi1 PF07491.11 PIK59191.1 - 1.4e-23 82.5 7.2 2.9e-23 81.5 7.2 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor TB PF00683.17 PIK59191.1 - 1.6 8.6 8.5 6.9 6.5 8.5 2.0 1 1 0 1 1 1 0 TB domain DUF1117 PF06547.12 PIK59193.1 - 0.29 11.7 2.0 0.91 10.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) LRR_9 PF14580.6 PIK59194.1 - 9.3e-18 64.3 6.8 3.6e-13 49.4 0.4 3.4 2 1 0 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 PIK59194.1 - 3.4e-15 55.9 37.6 9.1e-06 25.9 0.9 6.7 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK59194.1 - 3.7e-14 52.2 37.5 1.2e-07 31.3 0.7 6.5 3 2 3 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 PIK59194.1 - 0.0013 18.6 33.6 0.042 13.9 0.3 7.8 6 2 2 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 PIK59194.1 - 2.7 8.9 24.0 1.7 9.5 0.2 7.6 7 0 0 7 7 7 0 Leucine Rich Repeat CdvA PF18822.1 PIK59194.1 - 3.5 7.5 8.7 5.5 6.8 6.3 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain LRR_3 PF07725.12 PIK59194.1 - 5.2 7.1 7.7 6.9 6.7 0.0 4.7 6 0 0 6 6 6 0 Leucine Rich Repeat DUF745 PF05335.13 PIK59194.1 - 6.3 6.5 7.8 7.3 6.3 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) LRR_9 PF14580.6 PIK59195.1 - 9.7e-28 96.8 6.1 2e-13 50.3 0.7 5.1 2 2 2 5 5 5 4 Leucine-rich repeat LRR_4 PF12799.7 PIK59195.1 - 1.4e-18 66.6 38.5 5.5e-07 29.8 1.5 7.4 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK59195.1 - 4.7e-14 51.9 35.8 2.2e-08 33.7 4.0 5.7 4 2 2 6 6 6 5 Leucine rich repeat TSNAXIP1_N PF15739.5 PIK59196.1 - 4.5e-21 75.3 2.1 4.5e-21 75.3 2.1 2.6 2 0 0 2 2 2 1 Translin-associated factor X-interacting N-terminus Clathrin_H_link PF13838.6 PIK59196.1 - 3.6e-19 68.4 0.0 8.7e-19 67.2 0.0 1.7 1 0 0 1 1 1 1 Clathrin-H-link GAS PF13851.6 PIK59196.1 - 0.00044 19.7 15.3 0.058 12.7 0.7 2.3 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.12 PIK59196.1 - 0.27 11.2 7.6 1.2 9.1 0.0 3.0 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Piwi PF02171.17 PIK59196.1 - 0.52 9.5 2.6 0.51 9.5 0.1 1.9 2 0 0 2 2 2 0 Piwi domain bZIP_1 PF00170.21 PIK59196.1 - 0.75 9.9 14.7 0.17 12.0 0.3 4.1 4 0 0 4 4 4 0 bZIP transcription factor DUF2353 PF09789.9 PIK59196.1 - 1.8 7.9 18.7 0.95 8.8 10.9 2.3 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) TMPIT PF07851.13 PIK59196.1 - 7.8 5.6 11.3 0.91 8.7 0.4 2.3 1 1 0 2 2 2 0 TMPIT-like protein ZU5 PF00791.20 PIK59197.1 - 6.6e-11 42.4 0.1 1.2e-10 41.6 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK59198.1 - 3.7e-05 24.0 0.2 0.21 11.9 0.1 2.7 2 0 0 2 2 2 2 Death effector domain NLRC4_HD2 PF17776.1 PIK59198.1 - 0.04 14.4 0.1 0.12 12.9 0.0 1.8 2 0 0 2 2 2 0 NLRC4 helical domain HD2 Death PF00531.22 PIK59198.1 - 0.091 12.9 0.0 0.33 11.1 0.0 2.0 2 0 0 2 2 2 0 Death domain Death PF00531.22 PIK59199.1 - 1.8e-12 47.3 0.2 3.2e-12 46.4 0.2 1.4 1 0 0 1 1 1 1 Death domain RVT_1 PF00078.27 PIK59200.1 - 7.8e-08 32.1 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RCDG1 PF15725.5 PIK59200.1 - 7 7.1 9.0 20 5.7 9.0 1.8 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein C2-set_2 PF08205.12 PIK59202.1 - 6.7e-06 26.1 0.2 1.4e-05 25.1 0.2 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK59202.1 - 2.4e-05 24.5 0.0 6.6e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK59202.1 - 0.00028 21.0 0.1 0.12 12.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK59202.1 - 0.00034 21.2 0.4 0.14 12.8 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK59202.1 - 0.00064 19.7 0.1 0.0032 17.5 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK59202.1 - 0.0027 18.0 0.0 0.85 10.0 0.0 2.9 2 1 0 2 2 2 1 Immunoglobulin domain DUF2850 PF11012.8 PIK59202.1 - 0.13 12.6 0.1 0.52 10.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2850) ZU5 PF00791.20 PIK59204.1 - 9.9e-14 51.5 0.0 2.3e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK59204.1 - 3.2e-11 43.2 0.2 8e-11 42.0 0.2 1.7 1 0 0 1 1 1 1 Death domain Ig_3 PF13927.6 PIK59205.1 - 2.2e-12 47.4 0.2 4.1e-12 46.5 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK59205.1 - 2.2e-10 40.4 0.0 3.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK59205.1 - 4.3e-09 36.4 0.0 6.7e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK59205.1 - 5.2e-08 33.1 0.0 9.9e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK59205.1 - 0.0022 18.0 0.0 0.0049 16.9 0.0 1.7 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain CXCXC PF03128.14 PIK59205.1 - 0.032 14.6 17.7 0.46 11.0 5.1 3.7 3 0 0 3 3 3 0 CXCXC repeat FlgM PF04316.13 PIK59205.1 - 0.037 14.4 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM V-set PF07686.17 PIK59205.1 - 0.075 13.2 0.0 0.14 12.3 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin V-set domain hEGF PF12661.7 PIK59205.1 - 0.57 10.9 23.3 1.6 9.5 1.0 5.1 5 0 0 5 5 5 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK59205.1 - 9.4 6.7 35.8 3.2 8.2 2.5 3.8 3 1 0 3 3 3 0 EGF-like domain RNA_pol_Rpc4 PF05132.14 PIK59206.1 - 6.7e-31 107.7 0.0 6.7e-31 107.7 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase III RPC4 zf-C2H2_assoc2 PF16624.5 PIK59206.1 - 5 8.2 14.2 12 7.0 4.6 3.7 2 1 0 2 2 2 0 Unstructured region upstream of a zinc-finger ELO PF01151.18 PIK59207.1 - 2.4e-18 66.6 9.4 3.3e-18 66.1 9.4 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Pyridoxal_deC PF00282.19 PIK59208.1 - 6e-22 77.9 0.0 4.3e-19 68.5 0.0 2.3 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 PIK59208.1 - 4.8e-12 45.5 0.0 4.6e-09 35.7 0.0 2.5 2 1 0 2 2 2 2 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 PIK59208.1 - 8.6e-07 28.6 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.13 PIK59208.1 - 0.0019 17.0 0.0 0.0034 16.1 0.0 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Cys_Met_Meta_PP PF01053.20 PIK59208.1 - 0.0023 16.5 0.1 0.036 12.6 0.0 2.6 2 1 1 3 3 3 1 Cys/Met metabolism PLP-dependent enzyme Phage_min_tail PF05939.13 PIK59208.1 - 0.017 15.5 1.7 43 4.6 0.0 3.9 2 1 2 4 4 4 0 Phage minor tail protein HBD PF18534.1 PIK59208.1 - 0.066 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Helical bundle domain GPS PF01825.21 PIK59209.1 - 2.5e-15 56.7 5.5 4.2e-15 56.0 5.5 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Flagellin_C PF00700.21 PIK59209.1 - 0.12 12.8 0.2 0.18 12.2 0.2 1.3 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region DUF3823_C PF18003.1 PIK59209.1 - 0.23 12.2 1.1 0.39 11.5 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3823_C) Ldl_recept_a PF00057.18 PIK59210.1 - 3.5e-07 30.3 10.5 5.6e-07 29.7 10.5 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trans_reg_C PF00486.28 PIK59211.1 - 0.046 13.8 0.1 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal GPS PF01825.21 PIK59212.1 - 2.6e-14 53.5 3.7 2.6e-14 53.5 3.7 2.1 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif NPV_P10 PF05531.12 PIK59212.1 - 0.14 12.7 2.7 0.2 12.1 1.6 1.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CUB PF00431.20 PIK59213.1 - 2.1e-19 69.9 3.2 0.0084 16.4 0.1 5.6 5 0 0 5 5 5 5 CUB domain Ldl_recept_a PF00057.18 PIK59213.1 - 4.4e-13 49.2 36.9 0.00015 21.9 8.0 3.5 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A HlyD PF00529.20 PIK59213.1 - 5.2e-07 29.4 0.0 17 5.4 0.0 5.2 4 1 0 4 4 4 0 HlyD membrane-fusion protein of T1SS CheB_methylest PF01339.17 PIK59213.1 - 1.4e-06 28.1 0.0 28 4.4 0.0 5.1 5 0 0 5 5 5 0 CheB methylesterase DUF2993 PF11209.8 PIK59213.1 - 0.0031 17.8 0.0 45 4.2 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF2993) GDE_N_bis PF14742.6 PIK59213.1 - 0.03 13.9 0.0 26 4.3 0.0 3.6 5 0 0 5 5 5 0 N-terminal domain of (some) glycogen debranching enzymes V-set PF07686.17 PIK59213.1 - 0.083 13.1 5.9 1e+02 3.2 0.1 5.3 5 0 0 5 5 5 0 Immunoglobulin V-set domain tRNA-synt_1c_C PF03950.18 PIK59213.1 - 0.09 12.7 0.0 1.1e+02 2.5 0.0 3.8 4 0 0 4 4 4 0 tRNA synthetases class I (E and Q), anti-codon binding domain PyrI_C PF02748.15 PIK59213.1 - 0.56 10.2 12.3 21 5.1 0.1 3.7 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Imm31 PF15591.6 PIK59213.1 - 0.65 9.9 5.4 35 4.4 0.1 4.6 5 0 0 5 5 5 0 Immunity protein 31 DUF4912 PF16258.5 PIK59213.1 - 4.5 7.5 8.0 57 4.0 0.0 4.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4912) GPS PF01825.21 PIK59214.1 - 4e-16 59.3 5.7 9e-16 58.1 5.7 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Sushi PF00084.20 PIK59214.1 - 2.1e-07 31.4 12.4 0.00029 21.4 0.8 3.7 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) CUB PF00431.20 PIK59214.1 - 0.0037 17.6 0.0 0.009 16.3 0.0 1.6 1 0 0 1 1 1 1 CUB domain Phage_TAC_9 PF10876.8 PIK59214.1 - 0.092 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Phage tail assemb.y chaperone protein, TAC 7tm_2 PF00002.24 PIK59215.1 - 7.1e-29 100.8 23.4 1.1e-28 100.2 23.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK59215.1 - 2.3e-14 53.6 4.0 2.3e-14 53.6 4.0 2.5 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif DUF4149 PF13664.6 PIK59215.1 - 0.18 12.1 9.1 0.99 9.8 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) Cadherin PF00028.17 PIK59217.1 - 1.9e-112 367.9 22.9 1.7e-17 63.6 0.4 10.5 9 1 1 10 10 10 10 Cadherin domain Cadherin_3 PF16184.5 PIK59217.1 - 1.4e-06 28.2 22.0 0.01 15.8 0.0 7.6 9 0 0 9 9 9 4 Cadherin-like Cadherin_2 PF08266.12 PIK59217.1 - 1.8e-06 27.7 0.0 4 7.3 0.0 6.0 6 1 0 6 6 6 2 Cadherin-like PepSY PF03413.19 PIK59217.1 - 0.18 12.4 8.7 0.32 11.6 0.1 5.0 5 0 0 5 5 5 0 Peptidase propeptide and YPEB domain Cadherin PF00028.17 PIK59218.1 - 5.9e-147 478.6 35.3 8.7e-21 74.2 0.7 10.1 10 0 0 10 10 10 10 Cadherin domain Cadherin_2 PF08266.12 PIK59218.1 - 2.3e-18 65.8 0.0 0.18 11.7 0.0 9.5 9 0 0 9 9 9 4 Cadherin-like Cadherin_3 PF16184.5 PIK59218.1 - 7.6e-14 51.7 23.8 0.00015 21.7 0.3 9.2 9 1 0 10 10 10 4 Cadherin-like RET_CLD1 PF17756.1 PIK59218.1 - 4.4e-05 23.8 0.0 1.3 9.4 0.0 4.1 4 0 0 4 4 4 2 RET Cadherin like domain 1 Cadherin_4 PF17803.1 PIK59218.1 - 0.0012 19.4 80.4 0.073 13.7 0.8 10.0 9 1 0 9 9 9 5 Bacterial cadherin-like domain Big_9 PF17963.1 PIK59218.1 - 0.003 18.3 77.0 0.0073 17.0 6.7 9.5 8 1 1 9 9 9 3 Bacterial Ig domain PepSY PF03413.19 PIK59218.1 - 0.14 12.8 0.9 2.5 8.7 0.0 3.7 4 0 0 4 4 4 0 Peptidase propeptide and YPEB domain MG4 PF17789.1 PIK59218.1 - 0.52 10.5 6.0 2.8 8.2 0.1 4.1 5 0 0 5 5 5 0 Macroglobulin domain MG4 EGF PF00008.27 PIK59219.1 - 0.0016 18.7 6.2 0.0016 18.7 6.2 4.4 4 0 0 4 4 4 2 EGF-like domain hEGF PF12661.7 PIK59219.1 - 0.013 16.1 7.4 0.013 16.1 7.4 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF EGF_2 PF07974.13 PIK59219.1 - 1.2 9.5 32.3 0.15 12.4 8.0 3.1 3 0 0 3 3 3 0 EGF-like domain Collagen PF01391.18 PIK59220.1 - 4.2e-14 52.0 56.0 1.1e-08 34.7 21.0 3.1 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) DUF1902 PF08972.11 PIK59220.1 - 0.022 14.7 0.2 0.79 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) Collagen PF01391.18 PIK59221.1 - 4.4e-16 58.4 52.6 3.9e-09 36.1 23.6 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK59222.1 - 1.9e-12 46.8 37.8 3.8e-06 26.6 13.2 2.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK59223.1 - 8e-15 54.4 51.2 9.3e-09 34.9 23.8 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Pex24p PF06398.11 PIK59224.1 - 0.041 12.9 0.0 0.044 12.8 0.0 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin FYVE PF01363.21 PIK59225.1 - 2.3e-19 69.3 10.4 2.3e-19 69.3 10.4 1.9 2 0 0 2 2 2 1 FYVE zinc finger IBR PF01485.21 PIK59225.1 - 0.00048 20.3 6.9 0.0019 18.4 6.9 2.0 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Baculo_IE-1 PF05290.11 PIK59225.1 - 0.0037 17.2 2.7 0.0037 17.2 2.7 2.5 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) GIT_CC PF16559.5 PIK59225.1 - 0.0054 16.6 5.8 0.0054 16.6 5.8 4.5 4 2 1 5 5 5 1 GIT coiled-coil Rho guanine nucleotide exchange factor Cep57_CLD_2 PF14197.6 PIK59225.1 - 0.0095 16.0 11.7 0.0095 16.0 11.7 4.8 3 3 1 4 4 3 1 Centrosome localisation domain of PPC89 YabA PF06156.13 PIK59225.1 - 0.016 15.8 8.8 0.016 15.8 8.8 5.2 1 1 5 6 6 6 0 Initiation control protein YabA Tup_N PF08581.10 PIK59225.1 - 0.017 15.4 6.2 0.017 15.4 6.2 5.7 2 2 4 6 6 5 0 Tup N-terminal UPF0242 PF06785.11 PIK59225.1 - 0.017 15.2 16.3 0.017 15.2 16.3 3.1 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Trimer_CC PF08954.11 PIK59225.1 - 0.064 12.8 0.3 0.064 12.8 0.3 4.1 3 1 2 5 5 4 0 Trimerisation motif Fez1 PF06818.15 PIK59225.1 - 0.34 11.3 55.9 0.089 13.2 9.1 3.2 1 1 2 3 3 3 0 Fez1 ATG16 PF08614.11 PIK59225.1 - 0.54 10.4 59.1 2.6 8.2 14.2 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) zf-RING_5 PF14634.6 PIK59225.1 - 0.81 9.7 10.5 1.7 8.6 10.5 1.6 1 0 0 1 1 1 0 zinc-RING finger domain DUF724 PF05266.14 PIK59225.1 - 0.96 9.2 54.7 0.48 10.2 7.2 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF724) zf-RING_2 PF13639.6 PIK59225.1 - 1.1 9.7 9.9 3.6 8.0 5.8 2.4 2 0 0 2 2 2 0 Ring finger domain DUF1664 PF07889.12 PIK59225.1 - 1.2 9.2 40.7 0.16 12.0 5.0 4.5 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Filament PF00038.21 PIK59225.1 - 1.7 8.1 54.7 0.2 11.2 7.9 2.5 1 1 1 2 2 2 0 Intermediate filament protein Lipoprotein_7 PF01540.16 PIK59225.1 - 2.1 7.5 35.8 2.4 7.4 19.0 2.3 1 1 1 2 2 2 0 Adhesin lipoprotein Rootletin PF15035.6 PIK59225.1 - 2.3 8.2 53.2 0.037 14.1 20.1 3.3 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion LPP PF04728.13 PIK59225.1 - 2.9 8.3 19.6 0.33 11.4 0.4 5.6 3 3 2 5 5 4 0 Lipoprotein leucine-zipper ERM PF00769.19 PIK59225.1 - 2.9 7.6 62.9 1.3 8.8 14.0 3.4 1 1 2 3 3 3 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 PIK59225.1 - 3.5 6.2 44.8 9.7 4.7 6.0 2.9 1 1 1 2 2 2 0 AAA domain Mod_r PF07200.13 PIK59225.1 - 3.8 7.6 56.3 1.1 9.4 8.4 4.1 1 1 2 3 3 2 0 Modifier of rudimentary (Mod(r)) protein DUF641 PF04859.12 PIK59225.1 - 4.1 7.8 49.0 0.096 13.0 8.9 5.2 1 1 3 5 5 5 0 Plant protein of unknown function (DUF641) ADIP PF11559.8 PIK59225.1 - 4.7 7.3 60.9 0.25 11.4 8.2 4.3 1 1 3 4 4 3 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 PIK59225.1 - 5 7.2 68.7 0.031 14.3 11.1 6.2 1 1 4 6 6 4 0 TATA element modulatory factor 1 DNA binding APG17 PF04108.12 PIK59225.1 - 6 5.9 40.1 0.26 10.4 3.3 3.3 2 1 1 3 3 3 0 Autophagy protein Apg17 Spc7 PF08317.11 PIK59225.1 - 8.3 5.2 62.7 0.75 8.6 13.5 3.2 1 1 1 3 3 3 0 Spc7 kinetochore protein GAS PF13851.6 PIK59225.1 - 9.7 5.5 61.8 2.3 7.5 22.0 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Orn_DAP_Arg_deC PF00278.22 PIK59226.1 - 2.1e-11 43.9 0.0 2.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.16 PIK59227.1 - 1.5e-33 116.2 0.0 2.1e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain PhzC-PhzF PF02567.16 PIK59228.1 - 6e-47 160.4 0.0 8.7e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Peptidase_M24 PF00557.24 PIK59229.1 - 2.6e-27 95.9 0.0 1.1e-26 93.8 0.0 2.0 1 1 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 PIK59229.1 - 1.4e-20 73.4 11.2 3.2e-20 72.2 11.2 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 PIK59229.1 - 0.0016 18.5 6.2 0.0034 17.5 6.2 1.6 1 0 0 1 1 1 1 MYND finger GST_N PF02798.20 PIK59230.1 - 5.8e-10 39.4 0.0 1e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK59230.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK59230.1 - 0.019 15.7 0.0 0.033 14.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_3 PF14497.6 PIK59231.1 - 4.5e-22 78.1 0.2 6.4e-22 77.6 0.2 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK59231.1 - 4.7e-11 42.9 0.0 9.8e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK59231.1 - 3.9e-10 39.8 0.1 9.4e-10 38.6 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 PIK59231.1 - 5.5e-06 26.3 0.0 2.2e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK59231.1 - 1.7e-05 25.1 0.0 5.5e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK59231.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK59231.1 - 0.016 15.5 0.0 0.048 14.0 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 PIK59232.1 - 1e-20 73.7 0.3 1.7e-20 73.1 0.3 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK59232.1 - 1.6e-11 44.4 0.4 4.4e-11 43.0 0.0 2.0 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK59232.1 - 1.2e-10 41.5 0.1 2.2e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK59232.1 - 4.6e-05 23.7 0.0 8.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK59232.1 - 4.6e-05 23.3 0.0 8.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK59232.1 - 0.001 19.3 0.0 0.002 18.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK59232.1 - 0.0098 16.6 0.0 0.031 15.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_N_5 PF18485.1 PIK59232.1 - 0.058 13.7 0.0 0.37 11.2 0.0 2.2 3 0 0 3 3 3 0 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK59232.1 - 0.13 12.1 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK59233.1 - 8e-13 48.4 0.0 1.2e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK59233.1 - 1.8e-08 34.6 0.0 1e-07 32.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK59233.1 - 0.00012 22.3 0.0 0.00019 21.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK59233.1 - 0.00052 20.4 0.0 0.00098 19.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK59233.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK59233.1 - 0.0089 16.3 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Xpo1 PF08389.12 PIK59233.1 - 0.0094 16.0 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Exportin 1-like protein GST_N_4 PF17172.4 PIK59233.1 - 0.022 15.5 0.0 0.11 13.3 0.0 2.1 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain CLCA PF08434.11 PIK59234.1 - 3.7e-123 410.1 6.5 2.4e-62 210.7 0.0 3.6 3 0 0 3 3 3 3 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK59234.1 - 3.9e-30 105.4 4.0 8.6e-15 55.4 0.1 3.0 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 PIK59234.1 - 2.1e-26 92.6 0.9 7.4e-12 45.9 0.1 3.5 4 0 0 4 4 4 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 PIK59234.1 - 3.2e-19 69.2 0.0 2.3e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein VWA_3 PF13768.6 PIK59234.1 - 1.2e-10 41.6 0.2 2.5e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF1194 PF06707.11 PIK59234.1 - 3.5e-09 36.2 2.0 1.7e-05 24.2 0.1 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1194) vWA-TerF-like PF10138.9 PIK59234.1 - 4.5e-05 23.7 0.0 0.02 15.0 0.0 2.4 2 0 0 2 2 2 2 vWA found in TerF C terminus AAA_33 PF13671.6 PIK59234.1 - 0.19 11.9 0.0 0.43 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain STAT_alpha PF01017.20 PIK59235.1 - 0.0092 15.9 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 STAT protein, all-alpha domain DUF4479 PF14794.6 PIK59235.1 - 0.055 13.3 0.0 0.1 12.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) DUF2226 PF09987.9 PIK59235.1 - 0.055 12.8 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) IQ PF00612.27 PIK59237.1 - 2e-19 67.5 15.2 1.2e-05 24.7 0.5 4.7 4 0 0 4 4 4 4 IQ calmodulin-binding motif RasGAP PF00616.19 PIK59238.1 - 2e-34 119.1 0.3 4e-34 118.2 0.3 1.5 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Lant_dehydr_N PF04738.13 PIK59238.1 - 0.057 11.5 0.0 0.29 9.2 0.0 1.9 2 0 0 2 2 2 0 Lantibiotic dehydratase, N terminus RasGAP_C PF03836.15 PIK59239.1 - 5.5e-14 52.5 3.5 5.4e-12 46.0 3.5 2.2 1 1 0 1 1 1 1 RasGAP C-terminus Ribosomal_L22 PF00237.19 PIK59240.1 - 1e-42 144.6 0.0 1.5e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Y_phosphatase PF00102.27 PIK59241.1 - 2.4e-66 223.7 8.2 9.2e-34 117.0 1.5 3.1 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Stevor PF17410.2 PIK59241.1 - 0.18 11.3 3.2 0.33 10.5 3.2 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Ly49 PF08391.10 PIK59241.1 - 0.21 12.0 1.8 0.62 10.4 0.0 2.5 3 0 0 3 3 3 0 Ly49-like protein, N-terminal region RVT_1 PF00078.27 PIK59242.1 - 2.2e-42 145.1 1.0 4.9e-42 143.9 0.3 1.8 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipase_GDSL_2 PF13472.6 PIK59243.1 - 3.7e-08 34.0 0.0 2.5e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 PIK59243.1 - 1.8e-05 24.9 0.0 6.7e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PHD_2 PF13831.6 PIK59243.1 - 0.00011 21.6 3.3 0.00023 20.7 3.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 PIK59243.1 - 0.00011 22.0 8.1 0.0002 21.2 8.1 1.4 1 0 0 1 1 1 1 PHD-finger OSK PF17182.4 PIK59243.1 - 0.039 13.2 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 OSK domain PHM7_cyt PF14703.6 PIK59243.1 - 0.047 13.9 0.5 0.32 11.2 0.5 2.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter FYVE_2 PF02318.16 PIK59243.1 - 6.1 7.1 7.1 0.42 10.8 1.6 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger Y_phosphatase PF00102.27 PIK59244.1 - 0.00021 21.0 0.0 0.00024 20.7 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RVT_1 PF00078.27 PIK59245.1 - 1.7e-07 31.0 0.1 2.9e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S15 PF00312.22 PIK59245.1 - 0.17 12.1 2.1 0.21 11.8 0.3 2.1 2 0 0 2 2 2 0 Ribosomal protein S15 DUF2703 PF10865.8 PIK59245.1 - 0.18 12.0 1.1 0.49 10.6 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2703) DUF5446 PF17522.2 PIK59245.1 - 4.1 7.6 6.6 2.6 8.3 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Y_phosphatase PF00102.27 PIK59246.1 - 3.4e-29 102.1 0.1 5.6e-29 101.4 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase EphA2_TM PF14575.6 PIK59246.1 - 0.091 13.6 0.0 0.19 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain HTH_31 PF13560.6 PIK59247.1 - 1.5e-06 28.5 1.3 2.9e-06 27.5 0.4 2.0 2 0 0 2 2 1 1 Helix-turn-helix domain DDE_3 PF13358.6 PIK59247.1 - 2e-06 27.6 0.0 3.9e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_3 PF01381.22 PIK59247.1 - 2.9e-06 27.2 0.6 2e-05 24.6 0.3 2.4 2 0 0 2 2 2 1 Helix-turn-helix HTH_IclR PF09339.10 PIK59247.1 - 9.8e-05 22.1 0.0 0.0002 21.1 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 PIK59247.1 - 0.00026 20.8 0.5 0.00059 19.7 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_7 PF02796.15 PIK59247.1 - 0.00028 20.9 1.1 0.0078 16.3 0.1 3.0 4 0 0 4 4 2 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 PIK59247.1 - 0.00049 20.7 3.9 0.055 14.1 0.8 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 PIK59247.1 - 0.00068 19.3 1.1 0.0018 18.0 0.1 2.1 2 0 0 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.7 PIK59247.1 - 0.0012 18.7 0.1 0.0031 17.4 0.1 1.7 1 0 0 1 1 1 1 MarR family HTH_6 PF01418.17 PIK59247.1 - 0.0017 18.3 0.1 0.055 13.5 0.1 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain, rpiR family HTH_Tnp_ISL3 PF13542.6 PIK59247.1 - 0.0031 16.9 1.4 0.0058 16.0 0.1 2.2 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 HTH_17 PF12728.7 PIK59247.1 - 0.005 17.0 0.0 0.015 15.5 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 PIK59247.1 - 0.0051 16.3 2.2 0.014 14.9 0.3 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 PIK59247.1 - 0.0092 15.7 0.7 0.0092 15.7 0.7 2.5 3 1 1 4 4 2 1 Helix-turn-helix domain HTH_19 PF12844.7 PIK59247.1 - 0.0093 16.0 3.3 0.05 13.6 0.2 3.3 4 0 0 4 4 4 1 Helix-turn-helix domain HTH_Tnp_4 PF13613.6 PIK59247.1 - 0.011 15.4 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HTH_5 PF01022.20 PIK59247.1 - 0.015 15.1 0.4 0.033 14.1 0.1 1.7 2 0 0 2 2 1 0 Bacterial regulatory protein, arsR family SpoIIID PF12116.8 PIK59247.1 - 0.016 15.3 0.0 0.047 13.8 0.0 1.7 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_26 PF13443.6 PIK59247.1 - 0.018 15.5 0.1 0.053 14.0 0.1 1.8 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_29 PF13551.6 PIK59247.1 - 0.019 15.0 0.7 0.075 13.1 0.7 2.0 1 1 0 1 1 1 0 Winged helix-turn helix HTH_37 PF13744.6 PIK59247.1 - 0.022 14.7 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 PIK59247.1 - 0.04 13.6 0.4 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_25 PF13413.6 PIK59247.1 - 0.046 13.6 2.0 0.055 13.3 0.3 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 PIK59247.1 - 0.054 13.6 1.7 0.056 13.6 0.2 1.9 2 0 0 2 2 1 0 Helix-turn-helix domain LacI PF00356.21 PIK59247.1 - 0.055 13.3 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_49 PF18010.1 PIK59247.1 - 0.058 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Cry35Ab1 HTH C-terminal domain AT_hook PF02178.19 PIK59247.1 - 0.072 13.0 2.3 0.23 11.4 2.3 1.9 1 0 0 1 1 1 0 AT hook motif HTH_11 PF08279.12 PIK59247.1 - 2.2 8.3 5.4 2.3 8.2 0.2 3.2 4 0 0 4 4 4 0 HTH domain WWE PF02825.20 PIK59248.1 - 0.00017 22.1 21.5 1.8 9.2 0.3 7.1 1 1 3 5 5 5 5 WWE domain Helicase_C_2 PF13307.6 PIK59249.1 - 1.9e-22 80.2 0.0 2.1e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Helicase C-terminal domain Y_phosphatase PF00102.27 PIK59250.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase TPP_enzyme_M PF00205.22 PIK59251.1 - 1.2e-16 60.7 0.0 1.7e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.18 PIK59251.1 - 0.015 14.9 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain CO_dh PF02552.16 PIK59251.1 - 0.032 14.0 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit TPP_enzyme_N PF02776.18 PIK59252.1 - 1.9e-18 66.7 1.7 2e-18 66.6 1.7 1.0 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain T7SS_ESX_EspC PF10824.8 PIK59252.1 - 0.015 15.8 0.6 0.016 15.7 0.6 1.0 1 0 0 1 1 1 0 Excreted virulence factor EspC, type VII ESX diderm Death PF00531.22 PIK59253.1 - 1.1e-06 28.7 0.3 1.2e-06 28.5 0.3 1.2 1 0 0 1 1 1 1 Death domain DUF550 PF04447.12 PIK59253.1 - 0.15 12.2 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF550) Ephrin_rec_like PF07699.13 PIK59255.1 - 0.002 17.9 29.3 0.0021 17.8 1.4 4.4 3 2 1 4 4 4 2 Putative ephrin-receptor like Furin-like_2 PF15913.5 PIK59255.1 - 0.011 15.8 1.7 0.011 15.8 1.7 4.2 2 1 2 4 4 4 0 Furin-like repeat, cysteine-rich FixQ PF05545.11 PIK59255.1 - 0.21 11.6 0.1 0.21 11.6 0.1 2.1 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF2165 PF09933.9 PIK59255.1 - 0.49 10.4 8.4 0.27 11.2 0.6 2.9 2 1 1 3 3 3 0 Predicted small integral membrane protein (DUF2165) NCD3G PF07562.14 PIK59255.1 - 1.5 8.8 22.3 0.51 10.4 0.7 4.4 2 1 3 5 5 5 0 Nine Cysteines Domain of family 3 GPCR Neurensin PF14927.6 PIK59255.1 - 5.9 6.6 6.3 0.59 9.8 1.4 1.9 2 0 0 2 2 2 0 Neurensin LRR_8 PF13855.6 PIK59256.1 - 1.3e-14 53.7 9.1 6.2e-10 38.7 5.9 2.0 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK59256.1 - 3.4e-06 27.3 7.4 0.0008 19.8 3.6 2.1 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK59256.1 - 0.00051 20.0 0.0 0.00057 19.8 0.0 1.0 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK59256.1 - 0.0041 17.5 3.5 3.5 8.5 0.2 3.0 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK59256.1 - 4.1 7.7 8.4 2.3 8.5 0.8 2.9 3 0 0 3 3 3 0 Leucine Rich repeat Izumo-Ig PF16706.5 PIK59257.1 - 0.014 15.5 0.0 0.046 13.8 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Y_phosphatase PF00102.27 PIK59258.1 - 4e-17 62.6 0.0 8.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK59258.1 - 0.0031 17.8 0.2 0.79 10.1 0.0 3.2 3 0 0 3 3 3 1 Fibronectin type III domain fn3_2 PF16893.5 PIK59258.1 - 0.087 13.0 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 Fibronectin type III domain DUF4307 PF14155.6 PIK59258.1 - 0.2 11.5 0.5 10 6.0 0.3 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4307) LRR_8 PF13855.6 PIK59259.1 - 1.6e-31 107.9 28.8 1.2e-12 47.4 5.7 5.7 3 2 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 PIK59259.1 - 2.6e-16 59.4 34.9 0.00036 20.9 3.1 7.6 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK59259.1 - 1.9e-11 44.0 6.9 3.8e-05 23.7 4.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK59259.1 - 3e-08 33.1 15.0 3 8.7 0.0 8.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK59259.1 - 3.6e-05 23.3 13.7 9.3e-05 22.0 0.6 3.7 1 1 3 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 PIK59259.1 - 0.042 13.9 25.2 1.9 8.8 0.4 7.9 9 0 0 9 9 9 0 Leucine Rich repeat ASC PF00858.24 PIK59260.1 - 1.2e-74 251.9 5.5 1.8e-74 251.3 5.5 1.3 1 1 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.24 PIK59261.1 - 6.9e-77 259.3 0.6 8.3e-77 259.0 0.6 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Myb_DNA-bind_2 PF08914.11 PIK59262.1 - 5.5e-19 68.1 0.2 1.5e-18 66.7 0.2 1.8 1 0 0 1 1 1 1 Rap1 Myb domain BRCT_2 PF16589.5 PIK59262.1 - 8.2e-09 35.8 0.0 7.9e-08 32.6 0.0 2.5 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 PIK59262.1 - 0.00032 20.8 0.2 0.019 15.1 0.0 2.7 2 1 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.8 PIK59262.1 - 0.00043 20.3 0.0 0.0041 17.2 0.0 2.3 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 PIK59262.1 - 0.00067 19.7 0.6 0.0084 16.1 0.0 2.8 2 1 2 4 4 4 1 SLIDE Myb_DNA-bind_6 PF13921.6 PIK59262.1 - 0.071 13.4 0.6 6.3 7.1 0.2 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain MIEAP PF16026.5 PIK59263.1 - 1.9e-48 165.3 0.2 6.1e-48 163.7 0.0 1.8 2 0 0 2 2 2 1 Mitochondria-eating protein DUF4378 PF14309.6 PIK59263.1 - 0.0033 17.8 1.1 0.019 15.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4378) HsbA PF12296.8 PIK59263.1 - 0.31 11.5 2.0 19 5.7 0.0 2.7 2 1 0 2 2 2 0 Hydrophobic surface binding protein A Med18 PF09637.10 PIK59264.1 - 0.013 15.4 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Med18 protein GCFC PF07842.12 PIK59264.1 - 0.053 13.1 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein PrmA PF06325.13 PIK59265.1 - 1.6e-08 34.3 0.0 2.7e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 PIK59265.1 - 2.9e-07 31.1 0.1 1.2e-06 29.1 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 PIK59265.1 - 1.1e-05 25.1 0.1 2.4e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 PIK59265.1 - 0.00013 21.7 0.1 0.00056 19.7 0.0 2.0 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_18 PF12847.7 PIK59265.1 - 0.0009 19.2 0.1 0.0022 17.9 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK59265.1 - 0.0014 19.2 0.0 0.004 17.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK59265.1 - 0.0032 17.1 0.0 0.0069 16.0 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.20 PIK59265.1 - 0.007 15.5 0.0 0.016 14.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 PIK59265.1 - 0.0084 16.1 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59265.1 - 0.0089 16.8 0.0 0.039 14.7 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59265.1 - 0.011 15.5 0.0 0.037 13.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59265.1 - 0.016 15.0 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TPR_14 PF13428.6 PIK59265.1 - 0.031 15.1 0.0 0.6 11.1 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK59265.1 - 0.068 13.2 0.0 5.6 7.2 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK59265.1 - 0.15 12.3 0.0 0.41 10.9 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 PIK59265.1 - 0.16 11.7 0.0 5.7 6.7 0.0 2.4 1 1 1 2 2 2 0 TPR repeat DUF4371 PF14291.6 PIK59266.1 - 2.2e-05 24.2 0.2 3.7e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Zn_ribbon_17 PF17120.5 PIK59266.1 - 0.091 12.4 0.3 0.2 11.3 0.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-BED PF02892.15 PIK59266.1 - 0.19 11.7 2.6 0.52 10.4 2.6 1.7 1 0 0 1 1 1 0 BED zinc finger IBR PF01485.21 PIK59267.1 - 1.6e-20 73.1 32.3 1.1e-14 54.4 0.5 4.2 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 PIK59267.1 - 3.5e-05 24.0 9.0 3.5e-05 24.0 9.0 4.7 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 PIK59267.1 - 0.0017 18.3 11.5 0.0017 18.3 11.5 4.3 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK59267.1 - 0.0045 17.0 9.5 0.0045 17.0 9.5 3.9 4 0 0 4 4 4 2 RING-type zinc-finger zf-RING_11 PF17123.5 PIK59267.1 - 0.0073 16.0 7.5 0.0073 16.0 7.5 3.3 3 1 0 3 3 3 1 RING-like zinc finger RWD PF05773.22 PIK59268.1 - 1.2e-15 57.8 1.0 2.9e-15 56.6 0.1 2.1 2 0 0 2 2 2 1 RWD domain IBR PF01485.21 PIK59268.1 - 3.2e-11 43.3 28.0 3e-06 27.4 9.1 4.5 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 PIK59268.1 - 4.5e-05 23.7 9.0 4.5e-05 23.7 9.0 3.8 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK59268.1 - 0.0022 17.9 11.5 0.0022 17.9 11.5 3.2 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK59268.1 - 0.0057 16.6 9.5 0.0057 16.6 9.5 3.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 PIK59268.1 - 0.009 15.7 7.5 0.009 15.7 7.5 2.7 3 0 0 3 3 3 1 RING-like zinc finger HLH PF00010.26 PIK59269.1 - 7.8e-15 54.6 0.7 7.8e-15 54.6 0.7 2.8 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.5 PIK59269.1 - 0.038 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain DUF4726 PF15855.5 PIK59269.1 - 0.24 11.6 0.1 0.24 11.6 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4726) Lzipper-MIP1 PF14389.6 PIK59269.1 - 0.5 10.7 9.5 0.091 13.1 2.9 2.6 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Orthopox_A5L PF06193.11 PIK59270.1 - 0.099 12.1 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like RWD PF05773.22 PIK59271.1 - 9.2e-16 58.2 0.5 1.8e-15 57.3 0.5 1.4 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 PIK59271.1 - 4.1e-11 42.9 0.4 4.1e-11 42.9 0.4 3.5 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 PIK59271.1 - 0.0007 19.6 7.9 0.0007 19.6 7.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK59271.1 - 0.0027 17.5 8.7 0.0027 17.5 8.7 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK59271.1 - 0.0069 16.7 8.1 0.0069 16.7 8.1 3.0 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK59271.1 - 0.0073 16.2 20.7 0.0089 16.0 12.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK59271.1 - 0.33 10.9 21.7 0.95 9.4 9.0 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 PIK59271.1 - 2.3 8.0 12.4 7.1 6.5 12.4 1.9 1 0 0 1 1 1 0 RING-like zinc finger tRNA-synt_2 PF00152.20 PIK59273.1 - 1.7e-49 168.7 0.2 5.1e-46 157.2 0.1 2.1 1 1 1 2 2 2 2 tRNA synthetases class II (D, K and N) Melibiase_2 PF16499.5 PIK59274.1 - 5.6e-81 271.8 0.3 6.6e-81 271.6 0.3 1.0 1 0 0 1 1 1 1 Alpha galactosidase A HNOBA PF07701.14 PIK59275.1 - 2.1e-59 200.7 4.3 9.1e-59 198.6 4.3 1.9 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 PIK59275.1 - 2.2e-52 177.3 0.0 4.4e-52 176.3 0.0 1.5 1 0 0 1 1 1 1 Haem-NO-binding Guanylate_cyc PF00211.20 PIK59275.1 - 7.1e-50 169.2 0.1 1.2e-49 168.4 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Guanylate_cyc PF00211.20 PIK59276.1 - 4.1e-55 186.3 0.0 9.2e-55 185.1 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 PIK59276.1 - 3.6e-42 144.3 2.8 1.7e-40 138.9 2.8 2.1 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 PIK59276.1 - 3.7e-21 75.8 0.1 1.2e-20 74.1 0.0 1.9 2 0 0 2 2 2 1 Haem-NO-binding DUF4537 PF15057.6 PIK59277.1 - 2.8e-63 211.3 1.7 2.7e-25 88.8 0.1 3.7 3 0 0 3 3 3 3 Domain of unknown function (DUF4537) HALZ PF02183.18 PIK59277.1 - 1.3e-05 25.3 10.0 0.00021 21.4 0.7 3.1 2 1 1 3 3 3 2 Homeobox associated leucine zipper Tudor_3 PF18115.1 PIK59277.1 - 0.00017 21.3 0.0 2.3 8.1 0.0 4.0 4 0 0 4 4 4 2 DNA repair protein Crb2 Tudor domain Agenet PF05641.12 PIK59277.1 - 0.0045 17.4 0.0 24 5.5 0.0 4.2 3 0 0 3 3 3 1 Agenet domain VWA_3 PF13768.6 PIK59278.1 - 6.4e-30 104.1 0.2 6e-21 75.0 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA PF00092.28 PIK59278.1 - 4e-15 56.5 0.0 1e-09 38.9 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 PIK59278.1 - 2.1e-09 38.0 0.1 1.2e-06 29.1 0.0 2.8 2 0 0 2 2 2 2 von Willebrand factor type A domain Hrs_helical PF12210.8 PIK59278.1 - 0.042 14.4 0.1 0.17 12.4 0.1 2.0 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF2203 PF09969.9 PIK59278.1 - 0.098 13.4 0.2 0.37 11.5 0.2 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Recombinase PF07508.13 PIK59278.1 - 0.12 12.8 0.1 40 4.7 0.0 3.2 3 0 0 3 3 3 0 Recombinase Mn_catalase PF05067.12 PIK59279.1 - 0.0068 15.4 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Manganese containing catalase PCM1_C PF15717.5 PIK59281.1 - 3.8e-62 210.9 2.7 3.8e-62 210.9 2.7 2.9 2 2 1 3 3 3 1 Pericentriolar material 1 C terminus PCM1_C PF15717.5 PIK59282.1 - 1.1 7.9 82.4 0.012 14.3 59.8 2.9 1 1 1 2 2 2 0 Pericentriolar material 1 C terminus Guanylate_cyc PF00211.20 PIK59284.1 - 4.9e-53 179.5 0.1 5.9e-53 179.2 0.1 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF2935 PF11155.8 PIK59284.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) Guanylate_cyc PF00211.20 PIK59285.1 - 2.3e-11 43.7 0.0 4.2e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 PIK59285.1 - 0.00089 18.5 0.1 0.0014 17.9 0.1 1.2 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region F-box-like PF12937.7 PIK59286.1 - 2.1e-09 37.1 0.6 5.5e-09 35.8 0.6 1.8 1 0 0 1 1 1 1 F-box-like Sec7 PF01369.20 PIK59286.1 - 2.3e-09 37.2 0.0 3.8e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain F-box PF00646.33 PIK59286.1 - 3.8e-06 26.6 0.2 7.9e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 F-box domain DUF615 PF04751.14 PIK59286.1 - 0.089 12.8 0.0 0.21 11.6 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF615) Nup96 PF12110.8 PIK59287.1 - 8.9e-82 274.5 6.7 2.1e-81 273.3 6.7 1.6 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 PIK59288.1 - 3.9e-29 101.7 0.0 7.4e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 PIK59288.1 - 7.7 7.4 115.2 0.26 12.2 44.3 6.7 6 2 0 6 6 6 0 Nucleoporin FG repeat region START PF01852.19 PIK59289.1 - 2.8e-14 53.0 0.1 3.4e-14 52.8 0.1 1.0 1 0 0 1 1 1 1 START domain HLH PF00010.26 PIK59291.1 - 3e-15 55.9 1.3 1.8e-14 53.4 1.3 2.3 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain FapA PF03961.13 PIK59291.1 - 4.5 5.8 8.2 10 4.6 0.2 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A LMWPc PF01451.21 PIK59292.1 - 0.014 15.7 0.0 0.041 14.2 0.0 1.8 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase OHCU_decarbox PF09349.10 PIK59293.1 - 4.4e-24 85.7 0.0 5.6e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 OHCU decarboxylase YscK PF06578.12 PIK59293.1 - 0.021 14.3 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) DUF4190 PF13828.6 PIK59294.1 - 2.5e-06 27.1 1.6 4.1e-06 26.5 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4190) Col_cuticle_N PF01484.17 PIK59294.1 - 3 8.0 7.5 5.9 7.0 7.5 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain RVT_1 PF00078.27 PIK59295.1 - 1.1e-28 100.3 0.0 1.7e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CreA PF05981.12 PIK59295.1 - 0.027 14.4 0.0 0.093 12.7 0.0 1.8 2 0 0 2 2 2 0 CreA protein DUF5388 PF17363.2 PIK59295.1 - 0.11 12.7 0.2 0.31 11.3 0.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5388) Laminin_EGF PF00053.24 PIK59296.1 - 1.5e-14 53.8 110.8 0.0049 17.0 9.2 6.8 2 2 4 6 6 6 5 Laminin EGF domain EGF_2 PF07974.13 PIK59296.1 - 3.8e-13 49.6 136.9 0.00064 20.0 12.0 10.0 7 4 4 11 11 11 7 EGF-like domain hEGF PF12661.7 PIK59296.1 - 4e-06 27.3 97.6 0.00021 21.8 9.0 8.5 9 1 0 9 9 9 5 Human growth factor-like EGF DSL PF01414.19 PIK59296.1 - 0.00018 21.7 39.2 0.002 18.4 15.7 7.2 5 2 2 7 7 7 3 Delta serrate ligand EGF PF00008.27 PIK59296.1 - 0.011 16.1 11.5 0.011 16.1 11.5 8.5 9 0 0 9 9 9 0 EGF-like domain Pkinase_Tyr PF07714.17 PIK59298.1 - 1e-22 80.7 0.0 1.6e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK59298.1 - 6.9e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WBP-1 PF11669.8 PIK59298.1 - 0.028 15.0 0.0 0.12 13.0 0.0 2.0 1 1 1 2 2 2 0 WW domain-binding protein 1 DUF4834 PF16118.5 PIK59298.1 - 0.066 14.2 0.0 0.13 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SelK_SelG PF10961.8 PIK59299.1 - 0.021 15.4 1.7 0.032 14.8 1.7 1.3 1 1 0 1 1 1 0 Selenoprotein SelK_SelG BAR PF03114.18 PIK59300.1 - 4e-50 170.7 7.2 5.4e-50 170.3 7.2 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 PIK59300.1 - 6.9e-13 48.2 0.1 1.2e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK59300.1 - 1e-12 47.5 0.0 2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK59300.1 - 1.4e-12 47.0 0.1 2.3e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain BAR_2 PF10455.9 PIK59300.1 - 1.6e-11 43.9 5.4 2.2e-11 43.4 5.4 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 PIK59300.1 - 5.5e-05 23.0 6.8 0.00028 20.7 6.8 1.9 1 1 0 1 1 1 1 BAR domain of APPL family Prefoldin_3 PF13758.6 PIK59300.1 - 0.038 14.0 3.1 0.093 12.8 3.1 1.7 1 0 0 1 1 1 0 Prefoldin subunit AAA_11 PF13086.6 PIK59300.1 - 0.056 13.2 7.6 0.04 13.7 2.5 2.0 1 1 1 2 2 2 0 AAA domain Oxidored_q6 PF01058.22 PIK59301.1 - 6.5e-24 84.2 0.1 8.8e-24 83.8 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Ribosomal_S19 PF00203.21 PIK59302.1 - 1.1e-36 124.6 0.2 1.6e-36 124.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 UPF0236 PF06782.11 PIK59302.1 - 0.035 12.7 0.0 0.043 12.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) LCAT PF02450.15 PIK59302.1 - 0.091 11.9 0.1 0.098 11.8 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase IF2_assoc PF08364.11 PIK59302.1 - 3.8 7.8 8.3 0.34 11.2 3.0 2.1 2 0 0 2 2 2 0 Bacterial translation initiation factor IF-2 associated region AHD PF17793.1 PIK59303.1 - 2.1e-24 85.1 0.3 3.6e-24 84.3 0.3 1.4 1 0 0 1 1 1 1 ANC1 homology domain (AHD) YEATS PF03366.16 PIK59303.1 - 1.5e-08 34.4 0.0 3.4e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 YEATS family BET PF17035.5 PIK59303.1 - 0.00031 20.8 0.1 0.00068 19.8 0.1 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation GnHR_trans PF12369.8 PIK59303.1 - 1.7 9.5 4.9 1.4 9.7 0.1 3.3 3 1 1 4 4 4 0 Gonadotropin hormone receptor transmembrane region Na_Ca_ex PF01699.24 PIK59304.1 - 1.4e-23 83.5 22.6 3.1e-23 82.4 10.1 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF4051 PF13260.6 PIK59304.1 - 1.4 8.7 3.3 0.77 9.5 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) Na_Ca_ex PF01699.24 PIK59305.1 - 5.4e-09 36.2 1.4 9.4e-09 35.4 0.5 1.7 2 0 0 2 2 2 1 Sodium/calcium exchanger protein SabA_adhesion PF18304.1 PIK59305.1 - 0.026 13.8 0.0 0.033 13.4 0.0 1.1 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain RasGAP PF00616.19 PIK59306.1 - 1.4e-49 168.7 0.5 4.1e-49 167.1 0.5 1.9 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 PIK59306.1 - 5.3e-34 117.3 13.7 8.3e-34 116.7 9.1 2.8 3 0 0 3 3 3 1 RasGAP C-terminus CH PF00307.31 PIK59308.1 - 4e-19 68.8 0.0 5.6e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 PIK59308.1 - 0.00054 19.7 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Tex_N PF09371.10 PIK59308.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Tex-like protein N-terminal domain AAA_23 PF13476.6 PIK59309.1 - 4.4e-20 73.0 6.6 4.4e-20 73.0 6.6 2.8 1 1 1 2 2 1 1 AAA domain SMC_N PF02463.19 PIK59309.1 - 4.3e-13 49.2 8.9 8.7e-13 48.2 8.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK59309.1 - 3.8e-09 36.7 14.0 9.8e-09 35.4 14.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 PIK59309.1 - 0.00071 19.5 4.2 0.001 18.9 2.6 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Filo_VP35 PF02097.15 PIK59309.1 - 0.00079 18.6 0.2 0.0016 17.6 0.2 1.4 1 0 0 1 1 1 1 Filoviridae VP35 Myosin_tail_1 PF01576.19 PIK59309.1 - 0.0036 15.2 24.5 0.0056 14.6 24.5 1.2 1 0 0 1 1 1 1 Myosin tail AAA_29 PF13555.6 PIK59309.1 - 0.0051 16.5 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SLATT_fungal PF18142.1 PIK59309.1 - 0.032 14.2 4.7 3.1 7.8 0.5 3.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain HrpB7 PF09486.10 PIK59309.1 - 0.033 14.6 8.2 0.54 10.6 0.5 2.5 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) ChaC PF04752.12 PIK59309.1 - 0.073 13.1 0.4 0.12 12.4 0.4 1.4 1 0 0 1 1 1 0 ChaC-like protein FOXO-TAD PF16676.5 PIK59309.1 - 0.098 13.1 2.3 2.3 8.7 0.0 3.3 3 0 0 3 3 3 0 Transactivation domain of FOXO protein family TPK_catalytic PF04263.16 PIK59309.1 - 0.1 12.7 0.3 0.24 11.5 0.3 1.7 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain AAA_27 PF13514.6 PIK59309.1 - 0.12 12.0 4.6 0.46 10.1 0.0 3.0 2 1 1 3 3 3 0 AAA domain Tropomyosin PF00261.20 PIK59309.1 - 0.25 10.7 28.1 0.89 8.9 28.1 1.9 1 1 0 1 1 1 0 Tropomyosin PXA PF02194.15 PIK59309.1 - 0.35 10.8 5.6 0.051 13.6 0.9 1.9 2 0 0 2 2 2 0 PXA domain XhlA PF10779.9 PIK59309.1 - 0.36 11.0 19.1 0.058 13.6 2.6 3.5 3 1 0 3 3 2 0 Haemolysin XhlA DUF3450 PF11932.8 PIK59309.1 - 0.44 9.8 12.8 0.18 11.1 10.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) AAA_13 PF13166.6 PIK59309.1 - 0.45 9.1 24.7 1.5 7.4 18.4 2.5 2 1 0 2 2 2 0 AAA domain Laminin_II PF06009.12 PIK59309.1 - 0.5 10.4 16.5 0.092 12.8 10.3 2.6 1 1 1 2 2 2 0 Laminin Domain II DUF2730 PF10805.8 PIK59309.1 - 0.59 10.3 7.0 0.41 10.8 3.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) MCPsignal PF00015.21 PIK59309.1 - 0.89 9.3 9.4 0.53 10.1 4.0 2.4 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 PIK59309.1 - 2.4 8.7 14.6 51 4.4 7.9 4.2 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF745 PF05335.13 PIK59309.1 - 4.1 7.1 10.5 1.2 8.9 5.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) BLOC1_2 PF10046.9 PIK59309.1 - 4.6 7.6 13.2 2 8.7 4.8 3.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 PIK59309.1 - 8 7.0 28.0 2.3 8.7 13.3 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region SMC_N PF02463.19 PIK59310.1 - 5.5e-06 26.0 19.1 1.1e-05 24.9 19.1 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 PIK59310.1 - 3.9e-05 23.9 0.0 0.00018 21.8 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain APG6_N PF17675.1 PIK59310.1 - 0.017 15.6 25.1 0.017 15.6 25.1 4.9 2 1 4 6 6 4 0 Apg6 coiled-coil region Spc7 PF08317.11 PIK59310.1 - 0.043 12.7 55.7 0.011 14.7 16.0 4.2 2 1 2 4 4 4 0 Spc7 kinetochore protein SbcCD_C PF13558.6 PIK59310.1 - 0.07 13.4 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATG16 PF08614.11 PIK59310.1 - 0.15 12.3 56.6 0.068 13.4 11.2 4.4 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 PIK59310.1 - 0.26 11.4 53.7 0.059 13.4 19.2 5.1 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 PIK59310.1 - 0.71 9.6 58.1 0.31 10.7 26.2 4.9 2 1 2 4 4 4 0 Domain of unknown function (DUF4201) Fez1 PF06818.15 PIK59310.1 - 1.3 9.5 54.0 0.075 13.5 22.8 3.5 2 1 1 3 3 3 0 Fez1 ADIP PF11559.8 PIK59310.1 - 5 7.2 57.8 0.03 14.4 16.1 5.5 3 1 3 6 6 6 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 PIK59310.1 - 6.8 6.7 55.7 11 6.0 0.1 4.8 2 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 PIK59310.1 - 8.5 4.9 41.7 1.4 7.5 5.6 3.5 1 1 2 3 3 3 0 AAA domain DUF812 PF05667.11 PIK59310.1 - 9.4 5.0 52.1 0.51 9.1 37.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF812) SF3b10 PF07189.11 PIK59311.1 - 1.3e-39 134.1 0.0 1.5e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) RRM_3 PF08777.11 PIK59311.1 - 0.065 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif RCC1 PF00415.18 PIK59312.1 - 1.3e-28 99.4 3.5 5.7e-15 55.7 0.0 4.2 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK59312.1 - 9.2e-21 73.1 10.3 6.3e-09 35.4 0.7 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.6 PIK59312.1 - 0.16 11.8 0.3 18 5.2 0.0 2.7 3 0 0 3 3 3 0 PapC C-terminal domain SF3b10 PF07189.11 PIK59313.1 - 1.1e-39 134.4 0.0 1.2e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) RRM_3 PF08777.11 PIK59313.1 - 0.064 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Cu-oxidase_2 PF07731.14 PIK59314.1 - 2.5e-30 105.0 13.6 1.9e-16 60.1 0.3 6.8 6 2 0 6 6 6 5 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK59314.1 - 1.5e-23 83.0 0.2 1.5e-07 31.5 0.0 4.4 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 PIK59315.1 - 2.3e-18 66.3 3.6 1.2e-09 38.2 0.0 3.9 3 2 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 PIK59315.1 - 6.8e-07 29.1 1.4 0.27 10.9 0.1 4.3 3 1 0 3 3 3 3 Multicopper oxidase CFIA_Pcf11 PF11526.8 PIK59316.1 - 0.04 14.4 0.0 0.068 13.7 0.0 1.3 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 Rhamnogal_lyase PF06045.11 PIK59316.1 - 0.082 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Rhamnogalacturonate lyase family Cu-oxidase_3 PF07732.15 PIK59316.1 - 0.11 12.5 0.5 3.2 7.8 0.1 2.4 2 1 0 2 2 2 0 Multicopper oxidase Cu-oxidase_2 PF07731.14 PIK59317.1 - 4.5e-17 62.1 1.6 1.5e-16 60.4 1.6 1.7 1 1 0 1 1 1 1 Multicopper oxidase N6-adenineMlase PF10237.9 PIK59318.1 - 1.3e-33 116.0 0.2 1.7e-33 115.7 0.2 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase MelC1 PF06236.11 PIK59319.1 - 0.0028 17.7 4.2 5.3 7.2 0.1 3.5 2 2 1 3 3 3 3 Tyrosinase co-factor MelC1 DUF3368 PF11848.8 PIK59319.1 - 0.1 12.4 0.0 33 4.4 0.0 3.3 5 0 0 5 5 5 0 Domain of unknown function (DUF3368) HMG_box PF00505.19 PIK59320.1 - 4.2e-26 91.1 2.1 6.8e-26 90.5 1.5 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK59320.1 - 1.9e-09 38.0 0.3 3.8e-09 37.0 0.3 1.5 1 0 0 1 1 1 1 HMG-box domain DUF4806 PF16064.5 PIK59321.1 - 0.0025 18.1 0.1 0.0065 16.7 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4806) DUF1359 PF07097.11 PIK59321.1 - 0.23 11.7 1.6 0.58 10.4 1.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) Mis12 PF05859.12 PIK59322.1 - 3.1e-26 92.0 0.6 5.2e-26 91.3 0.6 1.4 1 0 0 1 1 1 1 Mis12 protein ALIX_LYPXL_bnd PF13949.6 PIK59322.1 - 0.00023 20.6 3.3 0.00025 20.5 2.0 1.6 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV SnoaL_3 PF13474.6 PIK59322.1 - 0.0026 18.0 0.1 0.0053 17.0 0.1 1.5 1 0 0 1 1 1 1 SnoaL-like domain tRNA-synt_1d PF00750.19 PIK59322.1 - 0.01 14.8 0.2 1.8 7.4 0.0 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (R) SKA2 PF16740.5 PIK59322.1 - 0.017 14.9 0.4 0.057 13.2 0.2 2.0 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Dynamitin PF04912.14 PIK59322.1 - 0.022 14.1 0.6 0.027 13.8 0.6 1.1 1 0 0 1 1 1 0 Dynamitin KASH_CCD PF14662.6 PIK59322.1 - 0.058 13.2 4.1 0.12 12.2 2.3 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Apolipoprotein PF01442.18 PIK59322.1 - 0.11 12.4 3.8 0.26 11.1 2.2 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DASH_Duo1 PF08651.10 PIK59322.1 - 0.11 12.2 0.9 0.27 11.1 0.9 1.6 1 0 0 1 1 1 0 DASH complex subunit Duo1 DUF4164 PF13747.6 PIK59322.1 - 1.5 9.1 5.2 2.1 8.7 0.6 2.9 2 2 2 4 4 4 0 Domain of unknown function (DUF4164) Peptidase_S28 PF05577.12 PIK59323.1 - 4.4e-120 401.4 5.9 9.1e-70 235.6 3.3 2.0 1 1 1 2 2 2 2 Serine carboxypeptidase S28 LRR_8 PF13855.6 PIK59324.1 - 3.2e-14 52.4 18.2 2.1e-09 37.0 4.7 3.3 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK59324.1 - 5.3e-09 36.2 22.7 0.00029 21.1 0.8 4.7 1 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK59324.1 - 0.00012 21.8 9.6 0.41 10.8 0.2 5.4 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 PIK59324.1 - 0.00026 21.1 23.5 3.2 8.7 0.0 6.8 6 0 0 6 6 6 4 Leucine Rich Repeat Pro_CA PF00484.19 PIK59325.1 - 3.6e-31 108.6 0.0 7.5e-31 107.5 0.0 1.5 1 1 0 1 1 1 1 Carbonic anhydrase SAM_1 PF00536.30 PIK59326.1 - 1.2e-18 67.3 0.1 2e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK59326.1 - 1.7e-17 63.3 0.1 2.7e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 PIK59326.1 - 0.00043 20.0 0.0 0.0014 18.4 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 PIK59326.1 - 0.0024 17.8 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK59326.1 - 0.019 14.9 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 PIK59326.1 - 0.025 14.8 0.1 0.045 14.0 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DAGK_acc PF00609.19 PIK59327.1 - 4.1e-50 170.2 0.0 5.1e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 PIK59328.1 - 1.4e-17 63.5 0.0 2.1e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 PIK59328.1 - 1.8e-16 59.8 32.1 5.2e-09 35.9 5.9 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 PIK59328.1 - 0.063 13.6 20.7 0.24 11.8 7.9 3.1 3 0 0 3 3 3 0 C1 domain EF-hand_7 PF13499.6 PIK59329.1 - 0.14 12.7 0.8 0.73 10.3 0.3 2.2 2 0 0 2 2 2 0 EF-hand domain pair START PF01852.19 PIK59332.1 - 3.1e-12 46.3 0.1 4.4e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 START domain 7tm_1 PF00001.21 PIK59334.1 - 1.6e-16 60.4 0.0 1.9e-16 60.2 0.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 PIK59334.1 - 0.064 13.6 0.0 0.16 12.3 0.0 1.7 2 0 0 2 2 2 0 Orf78 (ac78) 7tm_1 PF00001.21 PIK59335.1 - 1.1e-57 195.4 5.5 1.3e-57 195.1 5.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK59335.1 - 1e-12 48.0 7.5 1.4e-12 47.6 7.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK59335.1 - 2.3e-08 34.0 10.9 1.1e-07 31.8 10.9 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK59335.1 - 0.00019 21.3 5.9 0.00019 21.3 5.9 1.6 1 1 1 2 2 2 1 Olfactory receptor UPF0259 PF06790.11 PIK59335.1 - 0.1 12.3 10.6 0.017 14.9 3.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0259) Prominin PF05478.11 PIK59336.1 - 2.4e-10 39.1 0.2 2.9e-10 38.8 0.2 1.1 1 0 0 1 1 1 1 Prominin UPF0542 PF15086.6 PIK59336.1 - 0.076 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Phage_integrase PF00589.22 PIK59337.1 - 0.0084 15.9 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Prominin PF05478.11 PIK59338.1 - 3.5e-65 220.4 5.5 5.8e-38 130.4 5.1 2.2 1 1 1 2 2 2 2 Prominin Baculo_PEP_C PF04513.12 PIK59338.1 - 0.0002 21.4 28.1 0.0095 16.0 3.1 4.6 3 1 0 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2207 PF09972.9 PIK59338.1 - 0.00071 18.5 3.5 0.01 14.6 0.0 2.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) Tweety PF04906.13 PIK59338.1 - 0.0024 16.6 4.7 0.0024 16.6 4.7 3.9 3 2 1 4 4 4 1 Tweety DUF948 PF06103.11 PIK59338.1 - 0.0028 17.9 14.7 0.44 10.8 0.8 5.7 4 1 1 5 5 5 2 Bacterial protein of unknown function (DUF948) Shisa PF13908.6 PIK59338.1 - 0.022 15.0 4.3 4.5 7.5 3.0 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator NPV_P10 PF05531.12 PIK59338.1 - 0.075 13.5 28.5 0.41 11.1 1.5 5.5 3 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 PIK59338.1 - 0.11 13.0 12.0 38 4.8 0.1 5.1 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.9 PIK59338.1 - 0.28 11.2 1.6 0.67 10.0 0.4 2.4 2 0 0 2 2 2 0 Short coiled-coil protein DUF4064 PF13273.6 PIK59338.1 - 1.1 9.5 15.3 36 4.7 8.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) MCPsignal PF00015.21 PIK59338.1 - 3.1 7.6 11.1 5.5 6.8 0.2 3.3 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1542 PF07564.11 PIK59338.1 - 6.4 7.0 9.8 0.66 10.1 3.0 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1542) PID PF00640.23 PIK59339.1 - 0.00069 19.7 0.0 0.0021 18.1 0.0 1.8 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) C2 PF00168.30 PIK59341.1 - 1.7e-21 76.4 0.0 2e-21 76.2 0.0 1.0 1 0 0 1 1 1 1 C2 domain DAP3 PF10236.9 PIK59342.1 - 0.034 13.3 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 PIK59342.1 - 0.064 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 PIK59342.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 PIK59342.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpb2_7 PF04560.20 PIK59343.1 - 8.3e-16 58.2 0.3 1e-15 57.8 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_6 PF00562.28 PIK59343.1 - 9.9e-08 31.4 0.1 1.2e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 LAGLIDADG_2 PF03161.13 PIK59343.1 - 0.19 11.8 0.0 0.19 11.8 0.0 1.1 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family TRAP_alpha PF03896.16 PIK59344.1 - 2.2 7.4 6.1 0.12 11.6 0.8 1.5 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Bax1-I PF01027.20 PIK59346.1 - 1.1e-42 146.3 22.1 1.2e-42 146.0 22.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 PH_12 PF16457.5 PIK59347.1 - 1.9e-11 44.6 0.1 3.5e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_10 PF14788.6 PIK59347.1 - 3.3e-08 33.2 5.7 1.7e-07 31.0 1.4 2.8 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK59347.1 - 7.8e-06 25.4 1.1 0.0018 18.1 0.2 2.8 1 1 1 2 2 2 1 EF-hand domain PH PF00169.29 PIK59347.1 - 1.6e-05 25.4 0.2 2.9e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 PIK59347.1 - 4e-05 22.9 0.8 0.0016 17.9 0.1 2.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK59347.1 - 6.5e-05 23.3 1.9 0.00027 21.3 1.9 2.1 1 1 0 1 1 1 1 EF-hand domain pair Mcp5_PH PF12814.7 PIK59347.1 - 0.00023 21.3 0.1 0.00039 20.5 0.1 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_14 PF17787.1 PIK59347.1 - 0.00058 19.7 0.4 0.0084 16.0 0.4 2.3 1 1 0 1 1 1 1 PH domain EF-hand_5 PF13202.6 PIK59347.1 - 0.028 13.9 0.2 0.11 12.0 0.2 2.1 1 0 0 1 1 1 0 EF hand DUF3847 PF12958.7 PIK59347.1 - 0.082 13.0 1.9 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Baculo_PEP_C PF04513.12 PIK59347.1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PI-PLC-X PF00388.19 PIK59348.1 - 4.4e-18 65.3 0.3 5.2e-18 65.0 0.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 PIK59349.1 - 1.8e-19 70.2 0.2 4.6e-19 68.9 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 PIK59349.1 - 6.5e-16 58.5 0.2 1.6e-15 57.3 0.1 1.7 1 1 0 1 1 1 1 C2 domain 7tm_1 PF00001.21 PIK59351.1 - 2.7e-07 30.2 9.6 3.2e-07 29.9 9.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Guanylate_kin PF00625.21 PIK59352.1 - 1.1e-43 149.0 0.0 4.7e-43 147.0 0.0 1.9 1 1 0 1 1 1 1 Guanylate kinase SH3_1 PF00018.28 PIK59352.1 - 5.8e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK59352.1 - 5.6e-06 26.1 0.0 1.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK59352.1 - 4.4e-05 23.1 0.0 0.0001 21.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_5 PF07728.14 PIK59352.1 - 0.0074 16.3 0.0 0.092 12.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK59352.1 - 0.022 15.0 0.0 0.55 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 PIK59352.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PDZ PF00595.24 PIK59353.1 - 4.6e-11 42.9 0.5 8.7e-11 42.0 0.5 1.5 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 PIK59353.1 - 2e-09 37.1 0.0 3.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 L27 domain PDZ_6 PF17820.1 PIK59353.1 - 1.3e-07 31.4 0.2 3.2e-07 30.1 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK59353.1 - 0.00012 22.3 0.7 0.00024 21.4 0.4 1.5 1 1 0 1 1 1 1 PDZ domain Cu_amine_oxidN1 PF07833.11 PIK59353.1 - 0.065 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase N-terminal domain Spore_III_AF PF09581.10 PIK59354.1 - 0.0038 17.3 0.3 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Stage III sporulation protein AF (Spore_III_AF) ETRAMP PF09716.10 PIK59354.1 - 0.064 13.3 0.2 1.4 9.1 0.1 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SepZ PF06066.11 PIK59354.1 - 0.11 12.8 0.2 0.25 11.6 0.2 1.6 1 0 0 1 1 1 0 SepZ Methyltransf_FA PF12248.8 PIK59355.1 - 4.6e-08 33.3 0.0 1.4e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 Farnesoic acid 0-methyl transferase RVT_1 PF00078.27 PIK59356.1 - 1.2e-36 126.3 0.1 1.6e-36 125.9 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltransf_FA PF12248.8 PIK59358.1 - 3.7e-28 97.8 0.0 1.9e-10 41.0 0.0 4.5 4 1 0 4 4 4 4 Farnesoic acid 0-methyl transferase Glyco_transf_10 PF00852.19 PIK59360.1 - 2e-45 154.7 0.1 3.7e-45 153.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59360.1 - 4.3e-10 40.0 0.2 9.2e-10 39.0 0.2 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DivIVA PF05103.13 PIK59362.1 - 0.041 14.0 6.1 0.083 13.0 6.1 1.4 1 0 0 1 1 1 0 DivIVA protein SIS PF01380.22 PIK59362.1 - 0.049 13.5 0.2 0.085 12.7 0.2 1.3 1 0 0 1 1 1 0 SIS domain HCO3_cotransp PF00955.21 PIK59363.1 - 4.7e-202 672.3 3.2 6.2e-202 671.9 3.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 PIK59363.1 - 3.7e-89 299.1 0.3 3.7e-89 299.1 0.3 2.5 2 0 0 2 2 2 1 Band 3 cytoplasmic domain Xan_ur_permease PF00860.20 PIK59363.1 - 0.00053 18.8 14.1 0.0012 17.7 1.2 3.3 3 0 0 3 3 3 3 Permease family PTS_EIIA_2 PF00359.22 PIK59363.1 - 0.029 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 GpcrRhopsn4 PF10192.9 PIK59366.1 - 4.5e-22 78.7 18.4 6.5e-18 65.1 15.9 3.1 1 1 1 2 2 2 2 Rhodopsin-like GPCR transmembrane domain NIT PF08376.10 PIK59367.1 - 2.4e-16 60.9 0.0 3.1e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Nitrate and nitrite sensing Fib_alpha PF08702.10 PIK59367.1 - 0.093 12.9 0.8 0.34 11.1 0.1 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SUR7 PF06687.12 PIK59367.1 - 0.093 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 SUR7/PalI family ELMO_CED12 PF04727.13 PIK59369.1 - 2.3e-19 70.2 0.0 2.3e-19 70.2 0.0 1.8 2 1 0 2 2 2 1 ELMO/CED-12 family DUF572 PF04502.13 PIK59369.1 - 9.4 5.7 15.9 13 5.3 15.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF21 PF01595.20 PIK59370.1 - 2.5e-18 66.4 0.0 3.9e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 PIK59370.1 - 2.1e-06 28.1 2.9 0.046 14.2 0.2 3.8 2 1 1 3 3 3 2 CBS domain TcdB_N PF12918.7 PIK59370.1 - 0.035 14.4 0.7 9.3 6.6 0.1 2.5 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain WD40 PF00400.32 PIK59371.1 - 0.00013 22.7 0.3 49 5.0 0.0 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK59371.1 - 0.0049 17.2 0.0 0.063 13.6 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK59371.1 - 0.0094 15.0 0.0 1.1 8.1 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein VWA_2 PF13519.6 PIK59372.1 - 1.1e-19 71.0 0.1 9.7e-19 68.0 0.0 2.6 3 0 0 3 3 3 1 von Willebrand factor type A domain UIM PF02809.20 PIK59372.1 - 1.7e-06 27.5 21.5 0.0031 17.3 0.2 4.2 4 0 0 4 4 4 3 Ubiquitin interaction motif VWA PF00092.28 PIK59372.1 - 4.8e-06 26.9 0.1 1e-05 25.9 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 PIK59372.1 - 1.4e-05 25.0 0.3 2.9e-05 24.0 0.3 1.5 1 0 0 1 1 1 1 Ssl1-like RAP80_UIM PF18282.1 PIK59372.1 - 0.32 10.8 11.3 0.9 9.4 0.4 3.5 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif zf-C3HC4_3 PF13920.6 PIK59373.1 - 4.1e-13 49.0 9.8 6.3e-13 48.4 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK59373.1 - 0.00033 20.4 10.0 0.00059 19.6 10.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK59373.1 - 0.0049 17.2 11.7 0.0083 16.4 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK59373.1 - 0.094 12.6 13.3 0.16 11.8 13.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Utp21 PF04192.12 PIK59373.1 - 0.17 11.3 3.1 0.18 11.3 1.5 1.8 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain zf-RING_5 PF14634.6 PIK59373.1 - 0.18 11.8 11.0 0.34 10.9 11.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain SMC_N PF02463.19 PIK59374.1 - 9.7e-24 84.0 13.4 2.9e-23 82.4 13.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 PIK59374.1 - 4.4e-10 40.4 4.9 4.4e-10 40.4 4.9 3.7 1 1 1 3 3 1 1 AAA domain AAA_21 PF13304.6 PIK59374.1 - 0.00012 22.0 0.0 0.00012 22.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ERM PF00769.19 PIK59374.1 - 0.0018 18.1 9.6 0.0018 18.1 9.6 2.8 1 1 0 2 2 2 1 Ezrin/radixin/moesin family AAA_15 PF13175.6 PIK59374.1 - 0.0022 17.8 34.1 0.14 11.9 34.2 2.5 1 1 0 1 1 1 1 AAA ATPase domain HrpB7 PF09486.10 PIK59374.1 - 0.015 15.7 5.3 0.015 15.7 5.3 4.1 2 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) ATG16 PF08614.11 PIK59374.1 - 0.017 15.4 53.8 0.15 12.2 5.5 4.4 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) AAA_29 PF13555.6 PIK59374.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Spc7 PF08317.11 PIK59374.1 - 0.2 10.5 51.3 0.16 10.8 20.1 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Carbpep_Y_N PF05388.11 PIK59374.1 - 0.27 11.8 14.1 1.3 9.6 1.8 4.2 3 1 1 4 4 4 0 Carboxypeptidase Y pro-peptide Baculo_PEP_C PF04513.12 PIK59374.1 - 0.54 10.3 15.9 1.5 8.9 3.0 4.0 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 PIK59374.1 - 0.72 10.4 55.9 4.4 7.8 6.6 3.6 2 1 1 3 3 3 0 Apg6 coiled-coil region TMEM192 PF14802.6 PIK59374.1 - 0.75 8.8 5.3 1.1 8.2 2.0 2.2 2 0 0 2 2 2 0 TMEM192 family HOOK PF05622.12 PIK59374.1 - 2.6 6.1 50.1 1.8 6.6 31.4 2.2 1 1 1 2 2 2 0 HOOK protein DUF3584 PF12128.8 PIK59374.1 - 6.5 4.1 47.4 7.4 3.9 29.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 PIK59374.1 - 9.3 5.5 36.5 1.5 8.0 5.3 4.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF5641 PF18701.1 PIK59375.1 - 1.9e-28 98.4 2.3 4.4e-28 97.3 2.3 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK59375.1 - 2e-07 31.2 0.0 2.4e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59375.1 - 3.1e-05 24.0 0.8 8.3e-05 22.6 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain NYD-SP28_assoc PF14775.6 PIK59375.1 - 0.052 13.7 0.0 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 Sperm tail C-terminal domain DNA_pol_viral_C PF00336.18 PIK59375.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Peptidase_A17 PF05380.13 PIK59376.1 - 5.3e-40 137.1 0.0 8.4e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK59376.1 - 0.0056 16.2 0.0 0.0092 15.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RESP18 PF14948.6 PIK59376.1 - 0.034 14.5 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 RESP18 domain DUF321 PF03778.13 PIK59376.1 - 0.27 10.9 4.3 0.54 10.0 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF321) SMC_hinge PF06470.13 PIK59377.1 - 3.9e-13 49.7 0.0 1.1e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain EMP24_GP25L PF01105.24 PIK59377.1 - 0.011 15.6 2.5 0.011 15.6 2.5 2.5 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD KI67R PF08065.12 PIK59377.1 - 0.045 14.3 3.2 0.18 12.4 3.2 2.1 1 0 0 1 1 1 0 KI67R (NUC007) repeat APS-reductase_C PF12139.8 PIK59377.1 - 0.1 12.8 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 Adenosine-5'-phosphosulfate reductase beta subunit FUSC-like PF12805.7 PIK59377.1 - 0.15 11.1 0.8 0.33 10.0 0.4 1.8 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS Alpha-E PF04168.12 PIK59377.1 - 0.64 9.7 8.8 1.4 8.6 8.3 1.8 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. LsmAD PF06741.13 PIK59377.1 - 3 8.5 5.4 12 6.5 0.1 2.9 2 0 0 2 2 2 0 LsmAD domain DUF4806 PF16064.5 PIK59377.1 - 3.4 8.0 8.0 1.3 9.4 0.4 3.9 2 2 2 4 4 4 0 Domain of unknown function (DUF4806) Med4 PF10018.9 PIK59377.1 - 7.3 6.2 15.6 0.13 12.0 5.0 2.9 3 1 0 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 SMC_N PF02463.19 PIK59378.1 - 2.5e-32 112.1 0.0 2.9e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 PIK59378.1 - 2.2e-08 34.3 0.0 2.4e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 PIK59378.1 - 0.1 12.9 0.4 0.32 11.3 0.4 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit EF-hand_1 PF00036.32 PIK59379.1 - 4.7e-16 57.1 8.4 1.5e-06 27.3 0.6 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 PIK59379.1 - 2.6e-15 55.0 6.4 5.1e-06 26.0 0.3 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 PIK59379.1 - 3.6e-13 49.8 11.0 2.4e-08 34.3 1.7 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 PIK59379.1 - 3.7e-09 35.7 8.3 8.9e-07 28.1 0.4 3.6 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 PIK59379.1 - 8.8e-06 25.6 4.7 0.0051 16.7 0.4 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.6 PIK59379.1 - 3.2e-05 23.7 7.7 0.01 15.7 0.5 3.3 3 0 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK59379.1 - 1 9.7 6.2 0.8 10.0 0.1 2.8 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DNA_topoisoIV PF00521.20 PIK59380.1 - 2.3e-05 23.5 0.1 3.2e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_topoisoIV PF00521.20 PIK59381.1 - 3.1e-110 369.0 0.0 5.5e-110 368.2 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 PIK59381.1 - 4.1e-26 91.7 0.5 4.1e-26 91.7 0.5 3.2 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 PIK59381.1 - 3.3e-16 59.3 0.5 7.9e-16 58.0 0.5 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 PIK59381.1 - 4.3e-14 53.0 0.0 1.5e-13 51.3 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 PIK59381.1 - 2.7e-10 40.4 0.1 1.8e-09 37.7 0.0 2.4 2 0 0 2 2 2 1 Toprim domain UQ_con PF00179.26 PIK59382.1 - 9e-07 28.6 0.0 0.0014 18.2 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Amidase02_C PF12123.8 PIK59382.1 - 0.079 12.7 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase Sulfotransfer_2 PF03567.14 PIK59383.1 - 2.4e-23 83.3 0.0 3.2e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family TSP_1 PF00090.19 PIK59384.1 - 4.3e-37 126.1 159.6 0.0001 22.4 8.5 13.1 11 2 2 13 13 13 12 Thrombospondin type 1 domain DUF5417 PF17438.2 PIK59384.1 - 2.8e-09 37.2 12.7 0.59 10.5 0.2 5.2 4 0 0 4 4 4 4 Family of unknown function (DUF5417) VP7 PF00434.18 PIK59384.1 - 4.7e-05 22.7 67.1 0.29 10.3 0.4 7.0 1 1 6 7 7 7 7 Glycoprotein VP7 Phage_TAC_14 PF16462.5 PIK59384.1 - 0.019 15.2 12.5 1.4e+02 2.7 0.0 6.9 7 0 0 7 7 7 0 Phage tail assembly chaperone protein, TAC Presenilin PF01080.17 PIK59385.1 - 5 5.8 5.0 4.8 5.8 5.0 1.1 1 0 0 1 1 1 0 Presenilin Glyco_transf_10 PF00852.19 PIK59386.1 - 1.9e-39 135.2 0.0 3.6e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59386.1 - 2.5e-10 40.8 0.1 4.5e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59387.1 - 6.1e-53 179.2 2.7 9.1e-53 178.6 2.7 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59387.1 - 2.1e-09 37.8 1.2 1.1e-08 35.5 0.1 2.5 2 1 1 3 3 3 1 Fucosyltransferase, N-terminal Rubredoxin_2 PF18073.1 PIK59387.1 - 0.39 10.5 3.2 0.24 11.1 0.4 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain Glyco_transf_10 PF00852.19 PIK59388.1 - 2.5e-41 141.3 0.1 3.3e-41 141.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59388.1 - 3.3e-10 40.4 0.1 5.5e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59389.1 - 2e-35 122.1 1.5 2.9e-35 121.6 1.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59389.1 - 1e-08 35.6 0.0 2.3e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal FMO-like PF00743.19 PIK59390.1 - 1.6e-41 142.3 0.0 1.9e-41 142.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 PIK59390.1 - 0.018 14.3 0.0 0.024 13.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 PIK59391.1 - 1.5e-24 86.4 0.0 1.7e-24 86.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 PIK59391.1 - 1.2e-06 28.6 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 PIK59391.1 - 0.00069 18.9 0.0 0.00069 18.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 PIK59391.1 - 0.0061 15.7 0.0 0.0061 15.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 PIK59391.1 - 0.017 14.4 0.1 0.022 14.1 0.1 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 PIK59391.1 - 0.04 13.1 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 PIK59391.1 - 0.051 12.3 0.1 0.063 12.0 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 PIK59391.1 - 0.18 12.4 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PDZ_6 PF17820.1 PIK59392.1 - 7.6e-12 44.9 0.0 1.4e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK59392.1 - 1.1e-11 45.0 0.0 2.1e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK59392.1 - 1.9e-05 24.9 0.0 3.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 PIK59392.1 - 0.045 14.1 0.0 0.071 13.4 0.0 1.3 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain DUF4178 PF13785.6 PIK59392.1 - 0.049 13.8 0.1 0.076 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) GLTP PF08718.11 PIK59393.1 - 2.6e-14 53.8 0.0 4e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) GAD PF02938.14 PIK59393.1 - 0.014 15.6 0.2 0.028 14.6 0.2 1.5 1 1 0 1 1 1 0 GAD domain ANAPC4 PF12896.7 PIK59394.1 - 0.081 12.4 0.4 0.1 12.1 0.4 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 SNCAIP_SNCA_bd PF16700.5 PIK59394.1 - 0.23 11.2 2.7 0.74 9.6 0.3 2.4 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain PH PF00169.29 PIK59395.1 - 5.6e-14 52.5 0.0 7.8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK59395.1 - 3.1e-06 27.6 0.8 5.3e-05 23.6 0.7 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 PIK59395.1 - 0.00016 21.9 0.0 0.00037 20.7 0.0 1.6 2 0 0 2 2 2 1 Pleckstrin homology domain DUF5327 PF17261.2 PIK59395.1 - 0.05 14.3 0.3 0.069 13.9 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5327) FKBP_C PF00254.28 PIK59396.1 - 1.4e-12 47.7 0.1 2.8e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.6 PIK59396.1 - 1.1e-08 35.4 0.6 2.7e-08 34.1 0.6 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK59396.1 - 4.2e-08 32.2 7.1 0.0013 18.1 1.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK59396.1 - 1.5e-07 30.8 4.5 0.00032 20.4 0.5 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 PIK59396.1 - 4.2e-07 29.7 5.3 0.00069 19.4 0.4 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK59396.1 - 0.0003 20.1 7.9 0.045 13.3 0.7 2.7 2 0 0 2 2 2 2 EF hand Borrelia_REV PF03978.13 PIK59396.1 - 0.022 14.7 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Lipoprotein_19 PF13617.6 PIK59396.1 - 0.18 11.6 0.0 0.55 10.1 0.0 1.8 1 0 0 1 1 1 0 YnbE-like lipoprotein DHC_N2 PF08393.13 PIK59398.1 - 4.6e-154 513.3 7.1 4.6e-154 513.3 7.1 2.1 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 SAS4 PF15460.6 PIK59398.1 - 0.23 11.6 7.2 0.27 11.4 0.7 3.6 3 0 0 3 3 3 0 Something about silencing, SAS, complex subunit 4 Apolipoprotein PF01442.18 PIK59398.1 - 9.5 6.0 11.7 39 4.0 7.3 2.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain AAA_6 PF12774.7 PIK59399.1 - 2.2e-65 220.8 0.1 1.4e-52 178.7 0.0 3.3 2 1 1 3 3 3 3 Hydrolytic ATP binding site of dynein motor region Dynein_AAA_lid PF17852.1 PIK59399.1 - 4.3e-31 107.7 0.1 8.4e-31 106.7 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK59399.1 - 1.9e-05 24.7 0.0 0.00036 20.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 PIK59400.1 - 4.5e-76 254.4 0.0 6.8e-76 253.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 PIK59400.1 - 8.9e-21 74.0 0.0 2.6e-20 72.5 0.0 1.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 PIK59400.1 - 1.3e-06 28.4 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 PIK59400.1 - 0.029 14.6 0.0 0.071 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 PIK59400.1 - 0.034 14.6 0.0 0.071 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK59400.1 - 0.073 13.4 0.1 0.27 11.6 0.0 1.9 1 1 1 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 PIK59400.1 - 0.095 11.6 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain RHSP PF07999.11 PIK59400.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon hot spot protein AAA_14 PF13173.6 PIK59400.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK59400.1 - 0.15 12.0 0.2 0.42 10.5 0.0 1.8 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Ras PF00071.22 PIK59400.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Ras family AAA_8 PF12780.7 PIK59401.1 - 2.5e-76 256.5 0.1 9.7e-64 215.2 0.1 2.3 1 1 1 2 2 2 2 P-loop containing dynein motor region D4 AAA_9 PF12781.7 PIK59401.1 - 4.4e-61 205.8 0.1 4.4e-61 205.8 0.1 2.3 2 0 0 2 2 2 1 ATP-binding dynein motor region MT PF12777.7 PIK59401.1 - 2e-33 115.9 6.9 8.6e-32 110.5 7.1 2.6 1 1 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 PIK59401.1 - 0.0011 18.9 0.2 0.01 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DHR10 PF18595.1 PIK59401.1 - 0.0027 17.7 6.7 0.0027 17.7 6.7 2.6 3 0 0 3 3 3 1 Designed helical repeat protein 10 domain ATG16 PF08614.11 PIK59401.1 - 0.0072 16.6 0.4 0.0072 16.6 0.4 3.2 4 0 0 4 4 4 1 Autophagy protein 16 (ATG16) Spc7 PF08317.11 PIK59401.1 - 0.021 13.7 14.6 0.026 13.4 7.8 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein HrpB7 PF09486.10 PIK59401.1 - 0.17 12.2 8.0 0.17 12.3 2.3 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Dynein_C PF18199.1 PIK59403.1 - 2.1e-111 372.1 0.0 2.5e-111 371.8 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 PIK59403.1 - 2.3e-64 216.1 0.0 3.8e-64 215.4 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain LSM PF01423.22 PIK59404.1 - 9.9e-19 66.8 1.2 1.5e-18 66.3 1.2 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 PIK59404.1 - 0.12 12.5 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain Cucumo_2B PF03263.13 PIK59404.1 - 0.13 12.7 0.1 0.22 12.0 0.1 1.3 1 0 0 1 1 1 0 Cucumovirus protein 2B DUF4284 PF14112.6 PIK59405.1 - 0.04 14.9 0.7 0.045 14.7 0.7 1.1 1 0 0 1 1 1 0 Immunity protein 22 Methyltransf_16 PF10294.9 PIK59406.1 - 2.5e-13 50.1 0.3 3e-13 49.9 0.3 1.2 1 0 0 1 1 1 1 Lysine methyltransferase DUF5524 PF17662.1 PIK59407.1 - 4.2e-21 75.6 0.1 4.8e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5524) UMPH-1 PF05822.12 PIK59408.1 - 2.7e-70 236.7 3.5 4.8e-69 232.6 3.5 2.1 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 PIK59408.1 - 0.014 15.8 0.0 0.048 14.1 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK59408.1 - 0.064 13.3 0.3 0.25 11.4 0.0 2.1 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Chordopox_A35R PF05989.12 PIK59408.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A35R protein PHTB1_N PF14727.6 PIK59409.1 - 2.9e-58 198.2 0.0 3.6e-58 197.9 0.0 1.0 1 0 0 1 1 1 1 PTHB1 N-terminus F-box-like PF12937.7 PIK59410.1 - 6.5e-07 29.1 0.9 1e-06 28.5 0.9 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK59410.1 - 1.6e-06 27.8 1.1 2.5e-06 27.2 1.1 1.4 1 0 0 1 1 1 1 F-box domain FIST_C PF10442.9 PIK59411.1 - 4.6e-11 42.8 0.1 8.8e-11 41.9 0.0 1.5 1 1 0 1 1 1 1 FIST C domain FIST PF08495.10 PIK59411.1 - 0.02 14.9 0.2 0.91 9.5 0.0 2.6 2 1 0 2 2 2 0 FIST N domain MoCF_biosynth PF00994.24 PIK59411.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Probable molybdopterin binding domain Trypsin PF00089.26 PIK59412.1 - 1.1e-52 179.0 0.4 1.7e-52 178.5 0.4 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 PIK59412.1 - 3.7e-31 107.7 0.0 1.9e-13 50.7 0.0 4.0 4 0 0 4 4 4 2 CUB domain DUF1986 PF09342.11 PIK59412.1 - 1.8e-06 28.3 0.0 5.7e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ldl_recept_a PF00057.18 PIK59412.1 - 0.00016 21.8 6.5 0.00067 19.8 6.5 2.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK59413.1 - 4.7e-13 49.4 0.0 8.3e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 CUB domain Trypsin PF00089.26 PIK59413.1 - 4e-08 33.3 0.0 5.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin EGF_CA PF07645.15 PIK59413.1 - 4.4e-07 30.0 7.0 4.4e-07 30.0 7.0 3.7 4 1 0 4 4 4 1 Calcium-binding EGF domain EB PF01683.18 PIK59413.1 - 5e-05 23.5 3.1 5e-05 23.5 3.1 3.7 4 1 0 4 4 4 1 EB module hEGF PF12661.7 PIK59413.1 - 0.75 10.5 15.1 7.7 7.3 3.7 3.4 2 1 0 2 2 2 0 Human growth factor-like EGF cEGF PF12662.7 PIK59413.1 - 4 7.4 14.8 0.2 11.6 1.1 3.7 3 1 0 3 3 3 0 Complement Clr-like EGF-like Neur_chan_memb PF02932.16 PIK59414.1 - 1.8e-17 64.2 0.0 1.8e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 PIK59415.1 - 2e-27 96.1 1.0 1e-25 90.4 0.2 2.0 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Sugar_tr PF00083.24 PIK59416.1 - 1.4e-25 90.1 13.2 1.5e-22 80.1 1.1 2.4 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK59416.1 - 1.5e-21 76.7 11.6 3.8e-17 62.2 6.6 2.7 3 0 0 3 3 3 2 Major Facilitator Superfamily REJ PF02010.15 PIK59417.1 - 1.3e-21 77.0 8.2 2.4e-21 76.1 8.2 1.3 1 0 0 1 1 1 1 REJ domain Bundlin PF05307.11 PIK59417.1 - 0.041 13.7 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 Bundlin CheZ PF04344.13 PIK59417.1 - 0.079 12.9 0.3 0.14 12.0 0.3 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Arrestin_C PF02752.22 PIK59417.1 - 0.094 13.2 0.0 0.34 11.3 0.0 1.9 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain CorA PF01544.18 PIK59419.1 - 0.036 13.4 0.1 0.29 10.4 0.0 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Nbas_N PF15492.6 PIK59420.1 - 0.0051 16.2 0.0 0.0066 15.8 0.0 1.2 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Nbas_N PF15492.6 PIK59421.1 - 8.8e-53 179.4 0.4 2e-52 178.3 0.2 1.6 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal TEX19 PF15553.6 PIK59422.1 - 0.53 10.3 2.9 1.2 9.0 2.9 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 SAE2 PF08573.10 PIK59422.1 - 4.3 8.5 6.1 2.2 9.4 1.4 2.5 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Helicase_Sgs1 PF11408.8 PIK59423.1 - 0.092 12.8 0.1 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Sgs1 RecQ helicase DUF2935 PF11155.8 PIK59424.1 - 0.12 12.7 0.3 0.78 10.1 0.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) PDEase_I PF00233.19 PIK59425.1 - 5.6e-54 183.4 0.5 7.7e-54 182.9 0.5 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase AKAP95 PF04988.12 PIK59426.1 - 0.037 14.3 0.1 0.063 13.5 0.1 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Kinesin PF00225.23 PIK59428.1 - 1.5e-102 343.0 0.4 1.5e-102 343.0 0.4 1.4 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK59428.1 - 5.3e-47 159.5 0.3 1.3e-46 158.2 0.3 1.6 1 0 0 1 1 1 1 Microtubule binding DUF1664 PF07889.12 PIK59429.1 - 0.13 12.3 0.3 0.13 12.3 0.3 5.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) DUF3138 PF11336.8 PIK59429.1 - 0.19 10.3 16.0 1.1 7.8 7.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) EzrA PF06160.12 PIK59429.1 - 1.9 6.6 65.0 0.087 11.0 19.1 3.4 2 2 1 3 3 3 0 Septation ring formation regulator, EzrA Golgin_A5 PF09787.9 PIK59429.1 - 2 7.8 69.3 5.6 6.3 14.6 3.3 1 1 2 3 3 3 0 Golgin subfamily A member 5 Golgin_A5 PF09787.9 PIK59430.1 - 0.023 14.2 43.8 0.029 13.8 14.7 2.5 3 0 0 3 3 3 0 Golgin subfamily A member 5 QRPTase_C PF01729.19 PIK59430.1 - 0.089 12.6 0.2 0.089 12.6 0.2 2.4 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Spc7 PF08317.11 PIK59430.1 - 1.1 8.1 42.7 0.48 9.3 12.5 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 PIK59430.1 - 6.5 5.7 35.9 0.42 9.7 25.2 2.8 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GPO PF05929.11 PIK59430.1 - 7.1 6.2 22.5 8 6.0 6.5 2.6 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase fn3 PF00041.21 PIK59431.1 - 2e-23 82.5 8.1 6.8e-09 36.0 0.1 4.9 4 1 0 4 4 4 3 Fibronectin type III domain fn3_2 PF16893.5 PIK59431.1 - 7.2e-06 26.1 0.9 1.3 9.2 0.1 3.5 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK59431.1 - 0.0062 17.1 11.0 0.5 11.0 1.4 4.1 3 3 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 PIK59431.1 - 0.014 15.7 0.0 0.45 10.9 0.1 2.6 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 PIK59432.1 - 1e-34 118.8 11.9 4.6e-10 39.7 0.1 5.6 5 1 0 5 5 5 4 Fibronectin type III domain fn3_2 PF16893.5 PIK59432.1 - 7.6e-08 32.4 2.0 0.12 12.6 0.0 4.6 4 1 0 4 4 4 2 Fibronectin type III domain Tissue_fac PF01108.17 PIK59432.1 - 0.00027 20.7 0.3 0.94 9.4 0.0 3.9 3 1 2 5 5 5 2 Tissue factor Pur_ac_phosph_N PF16656.5 PIK59432.1 - 0.0013 19.2 12.9 1.2 9.8 0.3 5.4 4 4 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain CHASE4 PF05228.13 PIK59432.1 - 0.0082 16.4 0.1 8 6.7 0.0 3.7 3 1 1 4 4 4 1 CHASE4 domain fn3 PF00041.21 PIK59433.1 - 1.3e-24 86.4 7.3 8.5e-09 35.7 0.0 4.5 4 1 0 4 4 4 3 Fibronectin type III domain Interfer-bind PF09294.10 PIK59433.1 - 0.0077 16.5 0.0 6.4 7.1 0.0 3.4 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 PIK59433.1 - 0.17 12.1 3.0 7.8 6.7 0.1 3.7 4 0 0 4 4 4 0 Fibronectin type III domain fn3 PF00041.21 PIK59434.1 - 4.3e-22 78.3 2.2 3.7e-10 40.0 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 PIK59434.1 - 0.00038 20.7 0.1 0.025 14.9 0.3 2.2 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 PIK59435.1 - 7.8e-11 42.2 5.3 1.3e-05 25.5 0.1 3.4 4 1 0 4 4 4 2 Fibronectin type III domain fn3 PF00041.21 PIK59436.1 - 1.1e-12 48.1 4.4 1.1e-11 44.9 2.1 2.6 2 1 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 PIK59436.1 - 0.018 15.4 0.1 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 PIK59437.1 - 2.9e-33 114.0 14.0 3.2e-10 40.2 1.0 4.7 4 1 0 4 4 4 3 Fibronectin type III domain fn3_2 PF16893.5 PIK59437.1 - 4.1e-11 42.9 3.3 0.0023 18.1 0.0 4.4 4 1 0 4 4 4 2 Fibronectin type III domain Interfer-bind PF09294.10 PIK59437.1 - 2.2e-06 27.9 1.2 0.26 11.6 0.1 3.8 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 PIK59437.1 - 0.1 12.4 4.9 1 9.2 0.1 3.3 4 0 0 4 4 4 0 Tissue factor DUF493 PF04359.14 PIK59437.1 - 0.12 13.0 1.1 4.6 7.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF493) Pur_ac_phosph_N PF16656.5 PIK59437.1 - 0.8 10.3 17.9 0.79 10.3 0.7 4.5 4 3 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain SusE PF14292.6 PIK59437.1 - 1.2 9.4 5.5 15 5.9 0.3 3.9 2 1 3 5 5 5 0 SusE outer membrane protein fn3 PF00041.21 PIK59438.1 - 4.5e-20 71.8 4.3 3.6e-11 43.2 0.0 3.8 3 2 0 3 3 3 2 Fibronectin type III domain fn3_2 PF16893.5 PIK59438.1 - 0.0023 18.0 0.4 0.69 10.1 0.1 3.6 4 0 0 4 4 4 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK59438.1 - 0.16 12.6 5.9 0.29 11.7 0.1 3.6 2 2 1 3 3 3 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 PIK59439.1 - 3.1e-07 30.6 1.3 0.013 15.9 0.2 3.4 3 1 0 3 3 3 2 Fibronectin type III domain Ank_2 PF12796.7 PIK59440.1 - 1.6e-14 54.2 0.0 2.9e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) NUDIX PF00293.28 PIK59440.1 - 2.2e-14 53.6 0.0 5.4e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain Ank_4 PF13637.6 PIK59440.1 - 2.7e-12 46.9 0.3 2.5e-07 31.1 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK59440.1 - 2.2e-10 40.6 0.0 9.6e-10 38.5 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK59440.1 - 6.5e-08 32.7 0.0 1.1e-06 28.9 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat zf-NADH-PPase PF09297.11 PIK59440.1 - 1.5e-06 27.7 1.6 2.9e-06 26.8 1.6 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Ank_3 PF13606.6 PIK59440.1 - 5.3e-06 26.4 0.1 2.1e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat NUDIX-like PF09296.11 PIK59440.1 - 0.0002 22.0 0.0 0.00049 20.7 0.0 1.8 1 1 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain DNA_ligase_ZBD PF03119.16 PIK59440.1 - 0.13 12.3 2.4 0.27 11.3 2.4 1.5 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Zip PF02535.22 PIK59441.1 - 0.14 11.4 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GON PF08685.11 PIK59442.1 - 0.079 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 GON domain HlyIII PF03006.20 PIK59443.1 - 2.2e-48 164.9 17.8 2.9e-48 164.5 17.8 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 PIK59443.1 - 0.91 9.7 6.0 3.5 7.9 1.2 3.0 2 1 0 2 2 2 0 Low psii accumulation1 / Rep27 DUF4229 PF14012.6 PIK59443.1 - 1.8 8.7 13.1 0.34 11.0 3.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4229) ATP-synt_I PF03899.15 PIK59443.1 - 7 7.1 14.8 1.5 9.3 9.0 2.4 1 1 1 2 2 2 0 ATP synthase I chain Surp PF01805.20 PIK59444.1 - 1.3e-09 37.9 0.1 2.7e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 Surp module LLC1 PF14945.6 PIK59444.1 - 0.86 10.2 5.4 0.25 11.9 1.6 2.1 2 1 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Ndc1_Nup PF09531.10 PIK59444.1 - 5.3 5.6 11.6 8.7 4.9 11.6 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DHHC PF01529.20 PIK59445.1 - 1e-35 122.7 11.5 1e-35 122.7 11.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2681 PF10883.8 PIK59445.1 - 0.14 12.5 0.1 0.14 12.5 0.1 2.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2681) LSM PF01423.22 PIK59446.1 - 2.3e-16 59.2 0.1 3.3e-16 58.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 PIK59446.1 - 9.6e-05 22.5 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 PIK59446.1 - 0.029 14.5 0.1 0.045 13.9 0.1 1.4 1 1 0 1 1 1 0 Scd6-like Sm domain Ion_trans PF00520.31 PIK59447.1 - 1.7e-45 155.2 23.5 2.3e-45 154.7 23.5 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK59447.1 - 1.4e-09 37.2 15.0 7.6e-09 34.7 7.3 2.3 1 1 1 2 2 2 2 Polycystin cation channel DUF962 PF06127.11 PIK59447.1 - 0.15 12.2 2.1 0.21 11.7 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Vma12 PF11712.8 PIK59447.1 - 0.84 9.7 4.5 0.66 10.0 2.0 2.2 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Ion_trans PF00520.31 PIK59448.1 - 1.3e-30 106.5 6.3 1.8e-30 106.0 6.3 1.1 1 0 0 1 1 1 1 Ion transport protein GPHH PF16905.5 PIK59448.1 - 0.00019 21.1 0.0 0.00035 20.3 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 PIK59448.1 - 0.0012 17.6 4.6 0.0023 16.7 4.6 1.4 1 1 0 1 1 1 1 Polycystin cation channel DUF2534 PF10749.9 PIK59448.1 - 7.2 6.8 7.1 0.37 11.0 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2534) ParcG PF10274.9 PIK59449.1 - 8.8e-79 263.9 0.0 1.1e-78 263.6 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein NHL PF01436.21 PIK59450.1 - 1.7e-25 87.7 2.8 6.3e-07 29.1 0.0 5.4 5 0 0 5 5 5 4 NHL repeat Arylesterase PF01731.20 PIK59450.1 - 0.11 12.7 0.0 1.4 9.2 0.0 2.4 2 0 0 2 2 2 0 Arylesterase LRV_FeS PF05484.11 PIK59450.1 - 0.14 12.2 0.1 0.33 11.0 0.1 1.6 1 0 0 1 1 1 0 LRV protein FeS4 cluster Cu2_monooxygen PF01082.20 PIK59451.1 - 4.6e-08 33.4 0.0 7.2e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain NUDIX PF00293.28 PIK59452.1 - 1.1e-21 77.2 0.1 1.3e-21 77.0 0.1 1.0 1 0 0 1 1 1 1 NUDIX domain Kinesin PF00225.23 PIK59453.1 - 3.8e-71 239.7 0.2 6.9e-35 120.5 0.1 2.1 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 PIK59453.1 - 8.2e-16 58.3 0.0 1.4e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Fez1 PF06818.15 PIK59454.1 - 1.2 9.5 8.5 0.27 11.7 2.4 2.1 2 0 0 2 2 2 0 Fez1 PI3Ka PF00613.20 PIK59455.1 - 9.1e-59 198.0 2.3 1.6e-58 197.2 2.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 PIK59455.1 - 7.5e-45 152.3 0.1 1.6e-44 151.2 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3_PI4_kinase PF00454.27 PIK59455.1 - 4e-13 49.8 0.0 1.7e-12 47.7 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Sec23_trunk PF04811.15 PIK59456.1 - 9.3e-111 369.2 3.2 8e-81 271.2 0.3 2.2 2 0 0 2 2 2 2 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 PIK59456.1 - 1.2e-29 102.0 16.5 1.7e-14 53.5 4.3 2.8 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 PIK59456.1 - 5.2e-25 87.3 0.0 9.6e-25 86.4 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 PIK59456.1 - 1.8e-16 60.6 0.0 5.1e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sen15 PF09631.10 PIK59456.1 - 1.3e-09 38.3 0.1 0.0032 17.7 0.0 2.6 2 0 0 2 2 2 2 Sen15 protein Gelsolin PF00626.22 PIK59456.1 - 2.4e-06 27.3 0.0 5.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Transp_Tc5_C PF04236.15 PIK59456.1 - 0.051 13.9 1.9 15 6.0 0.0 3.1 3 0 0 3 3 3 0 Tc5 transposase C-terminal domain LIM PF00412.22 PIK59457.1 - 1.7e-11 44.1 4.9 2e-11 43.9 4.9 1.1 1 0 0 1 1 1 1 LIM domain SMN PF06003.12 PIK59458.1 - 0.26 10.5 7.5 0.36 10.1 6.1 1.9 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) zf-CCHC PF00098.23 PIK59459.1 - 3.4e-10 39.5 43.8 1.3e-05 25.0 1.3 5.9 6 0 0 6 6 6 4 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59459.1 - 9.6e-06 25.2 32.5 0.12 12.1 0.8 5.6 4 1 1 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.6 PIK59459.1 - 0.014 15.4 21.2 0.13 12.3 0.6 4.6 2 1 2 4 4 4 0 Zinc knuckle PAX PF00292.18 PIK59460.1 - 5.7e-49 165.2 0.7 3.6e-48 162.6 0.7 2.3 1 1 0 1 1 1 1 'Paired box' domain Recombinase PF07508.13 PIK59460.1 - 0.0079 16.6 0.1 0.017 15.5 0.1 1.5 1 0 0 1 1 1 1 Recombinase HTH_32 PF13565.6 PIK59460.1 - 0.092 13.4 1.1 3.5 8.3 0.0 2.9 2 1 1 3 3 3 0 Homeodomain-like domain GramPos_pilinD1 PF16555.5 PIK59460.1 - 0.16 12.1 2.9 0.32 11.1 2.9 1.5 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain Pyrophosphatase PF00719.19 PIK59464.1 - 1.1e-57 194.3 0.6 1.4e-57 193.9 0.6 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Pkinase PF00069.25 PIK59466.1 - 3.8e-18 65.8 0.0 9.7e-18 64.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59466.1 - 3e-14 52.9 0.0 8.6e-14 51.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Cornifin PF02389.15 PIK59466.1 - 1.9e-06 28.1 3.5 3.6e-06 27.2 3.5 1.4 1 0 0 1 1 1 1 Cornifin (SPRR) family Kinase-like PF14531.6 PIK59466.1 - 0.0024 17.3 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK59466.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trypan_PARP PF05887.11 PIK59466.1 - 3 7.8 14.5 5.3 7.0 14.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TUDOR PF00567.24 PIK59467.1 - 1.7e-20 73.3 0.0 1.5e-19 70.2 0.0 2.7 2 0 0 2 2 2 1 Tudor domain RRM_1 PF00076.22 PIK59467.1 - 2.1e-06 27.4 0.0 0.00014 21.6 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK59467.1 - 0.00035 20.6 1.0 0.034 14.3 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif DUF1616 PF07760.11 PIK59467.1 - 0.019 14.3 0.1 0.032 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) WhiA_N PF10298.9 PIK59467.1 - 0.97 9.5 2.9 22 5.2 0.4 3.2 2 1 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain CAML PF14963.6 PIK59468.1 - 0.0025 18.0 3.1 0.0025 18.0 3.1 2.1 2 0 0 2 2 2 2 Calcium signal-modulating cyclophilin ligand GH101_N PF17995.1 PIK59470.1 - 0.053 13.2 0.1 0.053 13.2 0.1 2.2 2 0 0 2 2 2 0 Endo-alpha-N-acetylgalactosaminidase N-terminal HMG_box PF00505.19 PIK59470.1 - 0.055 13.9 0.1 0.16 12.4 0.1 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box 7tm_1 PF00001.21 PIK59471.1 - 1.1e-37 129.9 13.3 1.1e-37 129.9 13.3 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Piezo_RRas_bdg PF12166.8 PIK59471.1 - 0.008 15.5 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain RCC1 PF00415.18 PIK59472.1 - 9.9e-39 131.7 16.4 6.3e-10 39.5 0.1 6.7 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK59472.1 - 5.4e-27 93.0 21.4 2.2e-07 30.5 0.0 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 PIK59472.1 - 4.1e-24 85.0 1.8 2.7e-22 79.1 0.2 2.3 2 0 0 2 2 2 2 BTB/POZ domain Peptidase_C25_C PF03785.14 PIK59472.1 - 0.037 13.9 0.3 0.98 9.3 0.1 2.7 2 1 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain BACK PF07707.15 PIK59472.1 - 0.12 12.4 2.3 0.33 11.1 0.5 2.3 2 0 0 2 2 2 0 BTB And C-terminal Kelch Ras PF00071.22 PIK59473.1 - 1.5e-25 89.7 0.0 1.8e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK59473.1 - 2.6e-20 72.8 0.0 3.1e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK59473.1 - 2.4e-08 33.6 0.0 2.7e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK59473.1 - 0.0043 16.4 0.0 0.005 16.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 PIK59473.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Ras PF00071.22 PIK59474.1 - 1.7e-10 40.7 0.0 2.7e-10 40.1 0.0 1.3 1 1 0 1 1 1 1 Ras family FSA_C PF10479.9 PIK59475.1 - 6.3e-72 242.8 9.0 1.3e-67 228.6 6.1 3.1 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus PEGSRP PF07623.11 PIK59476.1 - 0.058 13.2 0.3 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1584) Drf_FH3 PF06367.16 PIK59478.1 - 1.5e-20 73.6 0.9 2.9e-20 72.7 0.9 1.5 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 PIK59478.1 - 3.8e-17 62.5 0.6 3.8e-17 62.5 0.6 2.1 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain rve PF00665.26 PIK59481.1 - 1.7e-18 66.9 0.0 2.9e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK59481.1 - 4.3e-07 29.6 0.5 9.1e-07 28.6 0.1 1.7 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 PIK59482.1 - 1.1e-06 28.4 16.2 0.00076 19.4 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK59482.1 - 0.00094 19.0 8.2 0.12 12.2 3.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59482.1 - 0.025 14.4 0.2 0.025 14.4 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK59482.1 - 0.026 14.3 0.8 0.026 14.3 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK59482.1 - 0.053 13.3 11.1 5.7 6.8 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK59482.1 - 0.11 12.5 16.7 0.27 11.2 1.2 3.6 2 1 2 4 4 4 0 Zinc knuckle rve PF00665.26 PIK59483.1 - 4e-18 65.7 0.0 6.4e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59483.1 - 2.3e-06 27.6 1.3 6.1e-06 26.3 1.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain 2_5_RNA_ligase2 PF13563.6 PIK59483.1 - 0.0036 17.2 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK59483.1 - 0.024 14.4 0.0 0.07 12.9 0.0 1.9 1 1 0 1 1 1 0 Integrase core domain Exo_endo_phos PF03372.23 PIK59485.1 - 2.7e-10 40.1 0.1 3.5e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK59485.1 - 0.0011 18.8 0.0 0.003 17.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK59486.1 - 7.7e-35 120.4 0.0 1e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK59488.1 - 1.6e-08 34.2 15.1 0.00026 20.9 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59488.1 - 0.0027 17.4 11.1 2 8.2 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK59488.1 - 0.003 17.5 16.5 0.073 13.0 0.9 3.8 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59488.1 - 0.0089 15.8 0.2 0.0089 15.8 0.2 3.3 3 0 0 3 3 3 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK59488.1 - 0.009 15.7 0.8 0.009 15.7 0.8 2.8 1 1 1 2 2 2 1 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK59488.1 - 0.023 14.5 18.1 0.21 11.4 6.2 3.6 3 0 0 3 3 3 0 Zinc knuckle 7tm_3 PF00003.22 PIK59489.1 - 4.3e-40 137.9 19.5 5.8e-40 137.5 19.5 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR LapA_dom PF06305.11 PIK59489.1 - 6.3 6.7 7.6 9.2 6.2 0.1 2.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Kinesin PF00225.23 PIK59490.1 - 9.7e-31 106.9 4.4 6.2e-24 84.5 0.1 2.9 2 1 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 PIK59490.1 - 0.0011 18.9 0.3 0.0011 18.9 0.3 2.3 2 1 0 2 2 2 1 Microtubule binding Mvb12 PF09452.10 PIK59490.1 - 0.018 15.5 2.5 0.034 14.6 1.5 2.1 1 1 0 1 1 1 0 ESCRT-I subunit Mvb12 Somatostatin PF03002.15 PIK59490.1 - 0.25 11.3 1.2 0.62 10.0 1.2 1.6 1 0 0 1 1 1 0 Somatostatin/Cortistatin family DUF4748 PF15932.5 PIK59490.1 - 0.34 10.7 4.7 0.45 10.3 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) LRR_8 PF13855.6 PIK59491.1 - 4.1e-35 119.3 30.5 1.3e-08 34.5 0.3 6.3 1 1 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK59491.1 - 8.4e-31 105.5 29.4 1.2e-06 28.8 1.7 7.5 6 1 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK59491.1 - 2.5e-13 48.5 25.3 1.8 9.4 0.7 11.6 12 0 0 12 12 12 6 Leucine Rich Repeat LRR_9 PF14580.6 PIK59491.1 - 1.3e-07 31.2 10.9 0.035 13.6 0.9 4.0 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 PIK59491.1 - 0.0063 16.5 29.7 0.3 11.2 0.1 9.3 11 0 0 11 11 11 2 Leucine Rich repeat LRR_5 PF13306.6 PIK59491.1 - 0.026 14.5 0.1 0.081 12.9 0.1 1.8 1 1 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) DUF2441 PF10386.9 PIK59491.1 - 0.078 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2441) LRR_8 PF13855.6 PIK59492.1 - 1.9e-15 56.3 8.6 1.2e-05 25.0 0.4 3.3 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK59492.1 - 4.1e-12 46.1 13.3 2.6e-06 27.7 2.5 4.1 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) Death PF00531.22 PIK59492.1 - 6.3e-06 26.3 0.2 1.4e-05 25.2 0.2 1.6 1 0 0 1 1 1 1 Death domain LRR_1 PF00560.33 PIK59492.1 - 0.0004 20.5 12.2 3.1 8.7 0.2 5.5 4 1 1 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 PIK59492.1 - 0.014 14.9 0.2 0.054 13.0 0.2 1.9 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 PIK59492.1 - 0.037 14.1 4.4 9.7 6.5 0.5 3.7 3 0 0 3 3 3 0 Leucine Rich repeat zf-H2C2_2 PF13465.6 PIK59494.1 - 1.3e-36 123.4 81.9 9e-08 32.2 0.4 10.5 10 0 0 10 10 10 10 Zinc-finger double domain zf-C2H2 PF00096.26 PIK59494.1 - 1.2e-32 110.5 87.1 8.8e-05 22.8 0.7 10.8 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK59494.1 - 2.2e-23 80.9 83.2 0.0067 17.2 1.6 10.7 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK59494.1 - 2e-12 47.1 54.1 0.0071 16.6 0.1 10.2 9 1 1 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK59494.1 - 4.2e-12 45.8 77.3 0.0013 18.7 3.9 10.2 10 0 0 10 10 10 8 C2H2-type zinc finger zf-met PF12874.7 PIK59494.1 - 2.3e-05 24.6 56.7 0.083 13.3 0.3 9.7 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 PIK59494.1 - 0.00015 22.4 28.2 0.36 11.6 0.8 5.6 5 0 0 5 5 5 4 zinc-ribbon family Zn-ribbon_8 PF09723.10 PIK59494.1 - 0.0072 16.4 31.8 0.66 10.1 0.4 6.8 6 1 0 7 7 7 3 Zinc ribbon domain zf-H2C2_5 PF13909.6 PIK59494.1 - 0.02 14.7 0.2 0.02 14.7 0.2 7.9 7 3 0 7 7 7 0 C2H2-type zinc-finger domain Band_7 PF01145.25 PIK59497.1 - 3.2e-26 92.4 0.6 4.1e-26 92.1 0.6 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family RRM_3 PF08777.11 PIK59498.1 - 4e-21 75.0 1.7 4e-21 75.0 1.7 2.8 2 1 0 2 2 2 1 RNA binding motif La PF05383.17 PIK59498.1 - 2.4e-19 69.1 0.2 4.8e-19 68.2 0.2 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 PIK59498.1 - 1.4e-11 44.0 0.8 9.2e-09 35.0 0.3 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DHHA1 PF02272.19 PIK59498.1 - 0.0042 17.5 0.9 0.015 15.7 0.6 2.0 2 0 0 2 2 2 1 DHHA1 domain RRM_7 PF16367.5 PIK59498.1 - 0.11 12.7 0.4 0.32 11.2 0.4 1.9 1 0 0 1 1 1 0 RNA recognition motif Peptidase_S49_N PF08496.10 PIK59498.1 - 1.2 9.2 14.8 0.077 13.1 4.9 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal AIF_C PF14721.6 PIK59498.1 - 3.6 8.0 12.1 1.3 9.4 7.0 2.6 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DFRP_C PF16543.5 PIK59500.1 - 5.8e-23 81.2 8.7 5.8e-23 81.2 8.7 3.9 4 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 PIK59500.1 - 1.2e-08 35.6 13.7 1.6e-06 28.7 2.6 3.6 2 1 1 3 3 3 2 Torus domain zf-CCCH PF00642.24 PIK59500.1 - 3.4e-07 30.0 4.8 8.8e-07 28.7 1.2 2.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 PIK59500.1 - 5.2e-07 29.5 6.7 5.2e-07 29.5 6.7 3.7 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_4 PF18044.1 PIK59500.1 - 4.2e-06 26.4 2.1 4.2e-06 26.4 2.1 4.1 4 0 0 4 4 4 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 PIK59500.1 - 0.0066 16.9 16.1 0.14 12.7 4.8 3.6 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 PIK59500.1 - 0.31 11.3 9.5 0.091 13.0 1.9 3.2 3 1 0 3 3 3 0 Zinc-finger containing family AP-5_subunit_s1 PF15001.6 PIK59500.1 - 6 6.8 8.5 0.34 10.9 0.8 2.5 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 WD40_like PF17005.5 PIK59501.1 - 0.00037 19.9 0.3 0.00069 19.0 0.3 1.3 1 0 0 1 1 1 1 WD40-like domain Ank_2 PF12796.7 PIK59502.1 - 9.8e-17 61.3 0.1 7.2e-10 39.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK59502.1 - 5.7e-14 52.0 0.2 0.0001 22.5 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK59502.1 - 3.8e-11 43.3 0.1 7.4e-06 26.4 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) FERM_M PF00373.18 PIK59502.1 - 7.5e-10 39.2 0.0 1.6e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 FERM central domain Ank PF00023.30 PIK59502.1 - 7.9e-09 35.6 0.0 0.31 11.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 PIK59502.1 - 6.4e-07 29.2 0.2 0.013 16.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat UBA PF00627.31 PIK59502.1 - 0.087 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain MORN PF02493.20 PIK59503.1 - 5e-22 76.4 32.8 2.4e-05 24.0 1.2 8.6 8 0 0 8 8 8 8 MORN repeat VPS9 PF02204.18 PIK59503.1 - 4.4e-18 65.4 0.0 8.8e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RCC1 PF00415.18 PIK59503.1 - 4.1e-06 27.3 2.1 0.00012 22.7 0.2 2.7 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat PH PF00169.29 PIK59503.1 - 0.0042 17.6 0.1 0.011 16.2 0.1 1.7 1 0 0 1 1 1 1 PH domain RCC1_2 PF13540.6 PIK59503.1 - 0.016 15.0 6.1 0.019 14.8 1.5 2.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 PIK59504.1 - 1.3e-41 141.0 20.3 1.1e-12 48.4 1.3 5.4 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK59504.1 - 1.6e-22 78.8 27.4 1.3e-08 34.4 0.4 5.5 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat DarA_C PF18789.1 PIK59506.1 - 0.16 12.3 0.8 2.2 8.7 0.0 2.5 2 1 0 2 2 2 0 Defence against restriction A C-terminal Ly49 PF08391.10 PIK59507.1 - 3.1 8.2 5.2 2.1 8.7 2.1 2.0 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF4695 PF15766.5 PIK59508.1 - 8.3e-05 22.8 9.6 0.071 13.3 3.4 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF4695) Gelsolin PF00626.22 PIK59510.1 - 1.9e-06 27.7 0.1 3.8e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Gelsolin repeat HHV6-IE PF03753.13 PIK59510.1 - 0.03 11.8 0.0 0.04 11.4 0.0 1.0 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein VHP PF02209.19 PIK59511.1 - 3.6e-15 55.7 2.7 3.6e-15 55.7 2.7 2.0 2 0 0 2 2 2 1 Villin headpiece domain IgGFc_binding PF17517.2 PIK59512.1 - 9.6e-65 218.7 1.6 9.6e-65 218.7 1.6 1.6 2 0 0 2 2 2 1 IgGFc binding protein NTP_transferase PF00483.23 PIK59513.1 - 5.7e-29 101.4 0.0 9.2e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 PIK59513.1 - 3.7e-05 24.1 0.0 5.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 PIK59513.1 - 4e-05 23.2 8.6 0.015 15.0 1.1 4.4 4 1 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) DUF383 PF04063.14 PIK59514.1 - 0.0029 17.3 0.3 0.0052 16.5 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF383) DUF3361 PF11841.8 PIK59514.1 - 0.01 15.8 1.5 0.016 15.2 0.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) Proteasom_PSMB PF10508.9 PIK59514.1 - 0.021 13.3 0.1 0.026 13.1 0.1 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Arm PF00514.23 PIK59514.1 - 0.14 12.2 0.0 14 5.9 0.0 2.4 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat LETM1 PF07766.13 PIK59515.1 - 3.2e-18 66.0 0.6 4.3e-18 65.6 0.6 1.1 1 0 0 1 1 1 1 LETM1-like protein LETM1 PF07766.13 PIK59516.1 - 1e-22 80.8 1.5 1.1e-22 80.7 1.5 1.0 1 0 0 1 1 1 1 LETM1-like protein AAA_13 PF13166.6 PIK59518.1 - 0.0034 16.1 38.9 0.0034 16.1 38.9 3.9 1 1 3 4 4 4 3 AAA domain Baculo_PEP_C PF04513.12 PIK59518.1 - 0.007 16.4 9.9 0.007 16.4 9.9 5.2 5 1 1 6 6 6 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4400 PF14348.6 PIK59518.1 - 3.5 7.1 5.8 1.5 8.3 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4400) DUF1664 PF07889.12 PIK59518.1 - 5.1 7.2 59.5 0.065 13.3 6.9 6.7 5 2 2 7 7 7 0 Protein of unknown function (DUF1664) ASH PF15780.5 PIK59519.1 - 2.1e-23 82.4 2.4 0.0019 18.4 0.3 9.7 9 0 0 9 9 9 6 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 PIK59519.1 - 1.4e-10 41.0 0.7 4.1 7.3 0.0 7.9 7 0 0 7 7 7 2 MSP (Major sperm protein) domain PapD-like PF14874.6 PIK59519.1 - 1.2e-06 28.7 0.1 3.7 7.8 0.0 5.8 5 0 0 5 5 5 2 Flagellar-associated PapD-like TMEM131_like PF12371.8 PIK59519.1 - 3.7e-05 23.9 1.6 0.35 11.2 0.1 4.5 5 0 0 5 5 5 2 Transmembrane protein 131-like DUF1573 PF07610.11 PIK59519.1 - 0.00026 20.9 2.9 35 4.5 0.0 6.7 7 0 0 7 7 7 0 Protein of unknown function (DUF1573) STI1 PF17830.1 PIK59519.1 - 0.094 12.7 0.0 7.2 6.6 0.0 2.4 2 0 0 2 2 2 0 STI1 domain TSP_1 PF00090.19 PIK59520.1 - 1.5e-27 95.5 123.0 2.4e-07 30.8 9.9 10.8 11 0 0 11 11 11 8 Thrombospondin type 1 domain CUB PF00431.20 PIK59520.1 - 6.4e-07 29.7 0.4 8e-06 26.2 0.1 2.6 2 0 0 2 2 2 1 CUB domain ADAM_spacer1 PF05986.14 PIK59520.1 - 2.4e-05 24.3 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Pep_M12B_propep PF01562.19 PIK59521.1 - 2e-23 83.2 0.1 3.5e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.19 PIK59521.1 - 1.5e-08 34.8 0.1 0.0045 16.9 0.0 2.4 1 1 1 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 PIK59521.1 - 0.00013 22.1 0.0 0.00029 21.1 0.0 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Fam20C PF06702.12 PIK59521.1 - 0.087 12.6 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Golgi casein kinase, C-terminal, Fam20 Ribosomal_S26e PF01283.19 PIK59522.1 - 3.2e-53 178.7 8.9 3.8e-53 178.5 8.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e SAP PF02037.27 PIK59523.1 - 1e-06 28.3 1.3 1e-06 28.3 1.3 2.0 2 0 0 2 2 2 1 SAP domain Ish1 PF10281.9 PIK59523.1 - 0.015 15.6 0.2 0.027 14.8 0.2 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Telomere_Sde2_2 PF13297.6 PIK59523.1 - 0.03 14.0 0.1 0.064 12.9 0.1 1.5 1 0 0 1 1 1 0 Telomere stability C-terminal COS PF18568.1 PIK59523.1 - 0.043 13.7 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain HCO3_cotransp PF00955.21 PIK59524.1 - 5.4e-215 715.0 13.1 8.5e-215 714.4 13.1 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 PIK59524.1 - 2.8e-98 329.0 1.2 5.4e-98 328.1 0.2 1.8 2 0 0 2 2 2 1 Band 3 cytoplasmic domain SLX9 PF15341.6 PIK59524.1 - 6.9 7.1 7.7 32 4.9 0.2 2.5 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 Ependymin PF00811.18 PIK59525.1 - 8.1e-29 100.5 0.0 1.4e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Ependymin Trypan_PARP PF05887.11 PIK59525.1 - 0.29 11.1 5.3 0.48 10.4 5.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 PIK59525.1 - 0.51 10.8 4.3 1.1 9.8 4.3 1.4 1 0 0 1 1 1 0 TonB polyproline region NIF PF03031.18 PIK59527.1 - 0.0088 15.8 0.1 0.012 15.3 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase 7tm_1 PF00001.21 PIK59529.1 - 9.1e-21 74.4 9.8 1.1e-20 74.0 9.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK59529.1 - 0.025 13.9 2.2 0.034 13.5 2.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv RFX_DNA_binding PF02257.15 PIK59531.1 - 5.2e-30 103.9 0.3 1.1e-29 102.9 0.3 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain PHM7_cyt PF14703.6 PIK59531.1 - 0.027 14.7 0.2 0.05 13.8 0.2 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Pox_D5 PF03288.16 PIK59531.1 - 0.063 13.8 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Poxvirus D5 protein-like CLAMP PF14769.6 PIK59531.1 - 0.066 13.7 0.0 0.81 10.2 0.0 2.9 2 1 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 Coronavirus_5 PF05528.11 PIK59531.1 - 0.12 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Coronavirus gene 5 protein Rib_hydrolayse PF02267.17 PIK59532.1 - 9.7e-70 234.7 0.0 1.2e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase VWD PF00094.25 PIK59533.1 - 8e-36 123.7 0.0 1.2e-21 77.6 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 PIK59533.1 - 2.6e-12 47.0 1.1 2.6e-12 47.0 1.1 4.0 3 1 0 3 3 3 1 C8 domain TILa PF12714.7 PIK59533.1 - 4.5e-08 32.9 8.4 4.5e-08 32.9 8.4 3.5 2 1 1 3 3 3 1 TILa domain TIL PF01826.17 PIK59533.1 - 5e-08 33.1 15.6 5e-08 33.1 15.6 5.3 4 2 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK59533.1 - 0.00016 21.8 12.9 0.00016 21.8 12.9 3.9 2 1 1 3 3 3 1 EGF domain EGF_MSP1_1 PF12946.7 PIK59533.1 - 0.0037 17.3 7.0 0.0037 17.3 7.0 3.5 4 0 0 4 4 4 1 MSP1 EGF domain 1 VWD PF00094.25 PIK59534.1 - 4.5e-80 267.5 1.2 7.6e-30 104.3 0.1 3.3 3 0 0 3 3 3 3 von Willebrand factor type D domain TILa PF12714.7 PIK59534.1 - 5.1e-23 80.8 52.7 3.7e-09 36.4 11.9 8.5 7 1 1 8 8 8 4 TILa domain TIL PF01826.17 PIK59534.1 - 9.5e-18 64.2 56.4 2.5e-10 40.4 17.1 11.6 10 4 0 10 10 10 3 Trypsin Inhibitor like cysteine rich domain C8 PF08742.11 PIK59534.1 - 5.6e-13 49.1 11.2 1.4e-11 44.7 1.4 6.4 6 1 0 6 6 6 2 C8 domain EGF_3 PF12947.7 PIK59534.1 - 0.00026 21.1 12.6 0.00026 21.1 12.6 10.6 12 2 1 13 13 13 2 EGF domain EGF_MSP1_1 PF12946.7 PIK59534.1 - 0.0011 19.0 8.6 0.0011 19.0 8.6 6.8 6 0 0 6 6 6 2 MSP1 EGF domain 1 FAP206 PF12018.8 PIK59534.1 - 0.33 10.4 1.4 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function Fibrinogen_C PF00147.18 PIK59535.1 - 3.6e-56 190.4 5.1 6.2e-56 189.7 5.1 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain VWD PF00094.25 PIK59535.1 - 5.4e-43 147.0 4.7 8.7e-31 107.3 0.3 3.8 3 1 0 3 3 3 2 von Willebrand factor type D domain C8 PF08742.11 PIK59535.1 - 3.4e-28 97.8 12.3 2.4e-17 63.1 3.8 4.3 3 0 0 3 3 3 2 C8 domain TIL PF01826.17 PIK59535.1 - 4e-12 46.2 32.3 1.3e-07 31.7 8.5 7.6 6 3 1 8 8 8 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK59535.1 - 2.8e-11 43.2 10.8 2.8e-11 43.2 10.8 5.8 3 2 2 5 5 5 2 TILa domain EGF_3 PF12947.7 PIK59535.1 - 0.0019 18.3 7.2 0.0019 18.3 7.2 6.3 5 1 1 6 6 6 2 EGF domain EGF_MSP1_1 PF12946.7 PIK59535.1 - 0.014 15.4 8.1 0.014 15.4 8.1 5.1 5 0 0 5 5 5 0 MSP1 EGF domain 1 RabGAP-TBC PF00566.18 PIK59536.1 - 5.8e-53 179.7 0.6 8e-53 179.3 0.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4941 PF16299.5 PIK59536.1 - 0.1 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4941) Pyr_redox_2 PF07992.14 PIK59537.1 - 4.8e-44 150.8 5.1 6.1e-44 150.4 5.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK59537.1 - 2.5e-14 53.6 1.5 1.1e-10 41.9 0.8 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK59537.1 - 1e-12 48.4 4.0 0.0029 17.2 0.0 4.1 3 1 1 4 4 4 4 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK59537.1 - 3e-12 46.4 6.1 1.4e-11 44.3 3.7 2.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 PIK59537.1 - 2.4e-10 40.1 1.2 0.19 10.7 0.0 4.1 4 0 0 4 4 4 4 Lycopene cyclase protein NAD_binding_9 PF13454.6 PIK59537.1 - 2.4e-09 37.4 0.5 0.53 10.3 0.0 4.2 3 1 1 4 4 4 3 FAD-NAD(P)-binding K_oxygenase PF13434.6 PIK59537.1 - 4.3e-08 32.7 0.7 0.00011 21.4 0.1 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 PIK59537.1 - 1.6e-06 27.5 12.7 0.011 14.8 0.3 4.1 3 1 1 4 4 4 2 Glucose inhibited division protein A Amino_oxidase PF01593.24 PIK59537.1 - 2.3e-06 27.2 0.2 0.0012 18.2 0.1 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase ThiF PF00899.21 PIK59537.1 - 1e-05 25.0 0.0 0.06 12.7 0.0 2.4 2 0 0 2 2 2 2 ThiF family TrkA_N PF02254.18 PIK59537.1 - 2.7e-05 24.4 0.2 0.13 12.5 0.0 2.7 2 0 0 2 2 2 2 TrkA-N domain HI0933_like PF03486.14 PIK59537.1 - 0.0001 21.2 3.3 1 8.0 0.1 4.0 4 0 0 4 4 4 2 HI0933-like protein NAD_binding_8 PF13450.6 PIK59537.1 - 0.00021 21.4 0.0 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 PIK59537.1 - 0.00027 21.3 4.4 0.22 12.0 0.0 2.8 2 1 0 2 2 2 2 Putative NAD(P)-binding Thi4 PF01946.17 PIK59537.1 - 0.00027 20.2 1.0 0.052 12.8 0.1 2.7 3 0 0 3 3 3 1 Thi4 family DUF1188 PF06690.11 PIK59537.1 - 0.00069 19.2 0.0 0.0037 16.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) UDPG_MGDP_dh_N PF03721.14 PIK59537.1 - 0.00096 18.8 1.0 0.46 10.0 0.1 2.7 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 PIK59537.1 - 0.0019 18.3 2.7 4.5 7.3 0.2 3.7 3 1 1 4 4 4 2 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 PIK59537.1 - 0.0042 17.3 0.7 0.46 10.7 0.1 2.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Trp_halogenase PF04820.14 PIK59537.1 - 0.005 15.7 5.6 8 5.2 0.0 4.0 3 1 1 4 4 4 0 Tryptophan halogenase GFO_IDH_MocA PF01408.22 PIK59537.1 - 0.036 14.9 0.9 12 6.8 0.0 2.8 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold 2-Hacid_dh_C PF02826.19 PIK59537.1 - 0.054 12.8 0.0 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1344 PF07076.11 PIK59537.1 - 0.06 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Ldl_recept_b PF00058.17 PIK59538.1 - 3.2e-45 152.3 16.7 1.3e-08 35.2 0.1 10.3 10 0 0 10 10 10 8 Low-density lipoprotein receptor repeat class B Sushi PF00084.20 PIK59538.1 - 1.4e-44 150.5 95.8 1.6e-06 28.6 2.5 11.4 11 0 0 11 11 11 9 Sushi repeat (SCR repeat) HYR PF02494.16 PIK59538.1 - 1.2e-33 115.3 21.1 3.6e-12 46.4 2.4 6.0 6 0 0 6 6 6 4 HYR domain Ephrin_rec_like PF07699.13 PIK59538.1 - 1.5e-10 40.6 5.2 1.5e-10 40.6 5.2 3.0 2 0 0 2 2 2 1 Putative ephrin-receptor like FXa_inhibition PF14670.6 PIK59538.1 - 3.1e-09 36.9 11.1 3.1e-09 36.9 11.1 8.7 10 1 0 10 10 10 2 Coagulation Factor Xa inhibitory site SGL PF08450.12 PIK59538.1 - 2.7e-07 30.4 3.6 0.15 11.7 0.0 5.7 4 1 0 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region DUF2207 PF09972.9 PIK59538.1 - 0.065 12.0 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EGF PF00008.27 PIK59538.1 - 0.16 12.3 31.8 0.016 15.5 6.1 5.5 4 0 0 4 4 4 0 EGF-like domain CC PF04942.14 PIK59538.1 - 0.5 10.6 6.6 0.18 12.0 0.3 3.9 3 0 0 3 3 3 0 CC domain FBPase_glpX PF03320.13 PIK59539.1 - 0.14 11.0 0.6 0.26 10.1 0.0 1.6 2 0 0 2 2 2 0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded Mak16 PF04874.14 PIK59539.1 - 0.33 11.6 11.4 0.064 13.9 6.8 1.9 2 0 0 2 2 2 0 Mak16 protein C-terminal region DLEU7 PF15760.5 PIK59540.1 - 0.29 10.6 1.0 29 4.1 0.0 2.8 3 0 0 3 3 3 0 Leukemia-associated protein 7 Pkinase_Tyr PF07714.17 PIK59541.1 - 9.5e-75 251.2 0.0 1.3e-74 250.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WIF PF02019.18 PIK59541.1 - 1.3e-30 105.8 0.0 2.2e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 WIF domain Pkinase PF00069.25 PIK59541.1 - 1.1e-25 90.5 0.0 2e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Nucleoporin_FG PF13634.6 PIK59543.1 - 0.00078 20.2 25.7 0.00078 20.2 25.7 3.9 1 1 3 4 4 4 1 Nucleoporin FG repeat region Lectin_C PF00059.21 PIK59545.1 - 2.5e-38 131.1 8.4 1.9e-18 67.2 0.1 3.4 3 0 0 3 3 3 3 Lectin C-type domain Cadherin_C_2 PF16492.5 PIK59545.1 - 0.0032 18.2 0.0 0.0085 16.8 0.0 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal DUF4448 PF14610.6 PIK59545.1 - 0.035 13.9 0.1 0.059 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) PRIMA1 PF16101.5 PIK59545.1 - 0.093 12.8 0.3 0.22 11.6 0.3 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Lectin_C PF00059.21 PIK59546.1 - 2e-170 556.1 63.0 4e-20 72.5 1.2 11.8 10 1 1 11 11 11 11 Lectin C-type domain Kringle PF00051.18 PIK59546.1 - 2.2e-78 258.6 56.1 2.5e-18 66.2 8.3 8.3 7 0 0 7 7 7 7 Kringle domain UL45 PF05473.12 PIK59546.1 - 5.1e-16 58.9 22.6 0.061 13.0 0.3 10.7 11 0 0 11 11 11 6 UL45 protein, carbohydrate-binding C-type lectin-like PAN_1 PF00024.26 PIK59546.1 - 7.8e-10 38.6 0.7 5.2e-09 36.0 0.7 2.4 1 0 0 1 1 1 1 PAN domain Xlink PF00193.17 PIK59546.1 - 1.7e-05 25.1 10.5 14 6.2 0.0 9.5 9 1 1 10 10 10 1 Extracellular link domain Chordopox_A33R PF05966.12 PIK59546.1 - 0.011 15.0 13.5 8.4 5.6 0.1 7.3 10 0 0 10 10 10 0 Chordopoxvirus A33R protein UBA PF00627.31 PIK59547.1 - 5.9e-09 35.7 0.1 9.6e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.22 PIK59547.1 - 0.0035 17.4 7.8 0.006 16.6 7.8 1.5 1 1 0 1 1 1 1 Rhomboid family CUE PF02845.16 PIK59547.1 - 0.0062 16.2 0.2 0.013 15.2 0.2 1.5 1 0 0 1 1 1 1 CUE domain DER1 PF04511.15 PIK59547.1 - 0.041 13.8 1.0 0.078 12.9 1.0 1.4 1 0 0 1 1 1 0 Der1-like family DUF1751 PF08551.10 PIK59547.1 - 0.22 12.1 1.6 0.52 10.9 1.6 1.6 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) DUF1241 PF06840.11 PIK59548.1 - 4.8e-43 146.4 0.3 6.5e-43 146.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Sec8_exocyst PF04048.14 PIK59548.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain PG_binding_4 PF12229.8 PIK59548.1 - 0.17 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative peptidoglycan binding domain JmjC PF02373.22 PIK59549.1 - 2.1e-11 44.3 0.0 5.8e-11 42.8 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.28 PIK59550.1 - 8.1e-33 110.9 0.2 3.7e-06 26.5 0.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 PIK59550.1 - 1.8e-20 71.4 0.1 0.1 12.8 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 PIK59550.1 - 2.2e-14 52.4 0.1 0.056 13.7 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK59550.1 - 3.9e-13 48.8 3.3 0.0022 17.6 0.0 6.6 6 1 2 8 8 8 4 TPR repeat TPR_12 PF13424.6 PIK59550.1 - 2.4e-12 47.0 1.8 0.38 11.1 0.0 6.2 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK59550.1 - 6.7e-12 44.9 0.0 0.0047 17.2 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK59550.1 - 1.6e-10 41.4 0.0 0.18 12.5 0.0 5.1 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK59550.1 - 1.1e-07 32.1 0.0 0.52 11.3 0.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 PIK59550.1 - 1.2e-07 31.2 1.5 4.7 7.5 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK59550.1 - 3.1e-07 30.8 0.1 0.0064 17.0 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK59550.1 - 2.9e-06 27.3 0.2 0.26 11.4 0.0 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK59550.1 - 7.8e-06 26.2 0.5 6.6 7.6 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat ChAPs PF09295.10 PIK59550.1 - 0.0072 15.4 0.2 0.055 12.5 0.0 2.1 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 PIK59550.1 - 0.013 14.9 0.5 1.2 8.5 0.0 2.5 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 PIK59550.1 - 0.028 14.6 0.0 0.028 14.6 0.0 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 PIK59550.1 - 0.046 12.9 0.4 0.75 9.0 0.1 2.7 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK59551.1 - 6.1e-07 29.2 0.1 3.2e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK59551.1 - 4.2e-06 26.4 0.4 6.1e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK59551.1 - 1.4e-05 24.8 0.1 0.00013 21.8 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK59551.1 - 3.2e-05 23.6 0.1 0.017 15.1 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK59551.1 - 0.00073 20.0 0.0 0.025 15.2 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK59551.1 - 0.0014 18.9 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK59551.1 - 0.031 15.1 0.0 0.57 11.2 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat PG_binding_1 PF01471.18 PIK59551.1 - 0.11 12.7 0.1 4.2 7.6 0.0 2.1 2 0 0 2 2 2 0 Putative peptidoglycan binding domain Glyco_transf_22 PF03901.17 PIK59552.1 - 6.4e-82 276.0 28.1 7.6e-82 275.7 28.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family RPN2_C PF18004.1 PIK59553.1 - 3.6e-48 163.5 23.7 3.7e-27 95.2 19.4 2.2 1 1 1 2 2 2 2 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 PIK59553.1 - 9.8e-23 79.4 10.4 0.0002 21.6 0.1 5.6 5 0 0 5 5 5 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 PIK59553.1 - 6.1e-16 58.6 0.1 7.3e-13 48.7 0.0 3.0 1 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 PIK59553.1 - 0.00027 20.9 0.2 1.8 9.0 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 PIK59553.1 - 0.059 13.9 0.4 16 6.1 0.1 3.4 2 1 2 4 4 4 0 HEAT-like repeat Zip PF02535.22 PIK59553.1 - 0.066 12.4 1.3 0.12 11.6 1.3 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.17 PIK59553.1 - 0.17 12.0 6.8 0.32 11.1 6.8 1.4 1 0 0 1 1 1 0 DDHD domain SPATIAL PF15256.6 PIK59553.1 - 1.5 9.1 10.4 2.7 8.3 10.0 1.6 1 1 0 1 1 1 0 SPATIAL DUF4820 PF16091.5 PIK59553.1 - 2.2 7.6 9.3 17 4.7 10.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) PC_rep PF01851.22 PIK59554.1 - 0.00071 19.9 0.0 0.0025 18.1 0.0 2.0 1 0 0 1 1 1 1 Proteasome/cyclosome repeat XRCC4 PF06632.12 PIK59554.1 - 0.0025 16.7 4.9 0.0029 16.5 0.0 2.1 2 0 0 2 2 2 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF4552 PF15089.6 PIK59554.1 - 0.092 11.8 2.6 0.13 11.3 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) Cob_adeno_trans PF01923.18 PIK59554.1 - 0.12 12.5 0.1 0.38 10.9 0.1 1.8 1 0 0 1 1 1 0 Cobalamin adenosyltransferase FGGY_N PF00370.21 PIK59555.1 - 2.5e-29 102.6 3.7 2.4e-27 96.1 3.7 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DUF4052 PF13261.6 PIK59555.1 - 0.057 13.3 0.5 0.27 11.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4052) Nt_Gln_amidase PF09764.9 PIK59555.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 N-terminal glutamine amidase Raco_middle PF17651.1 PIK59555.1 - 0.17 11.5 0.3 2.2 8.0 0.1 2.1 1 1 1 2 2 2 0 RACo middle region FGGY_C PF02782.16 PIK59556.1 - 3.6e-25 88.9 0.2 8.4e-23 81.1 0.0 2.1 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, C-terminal domain RVT_1 PF00078.27 PIK59557.1 - 3.8e-08 33.1 0.0 4.1e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WSC PF01822.19 PIK59558.1 - 3.8e-12 46.2 1.2 5.7e-12 45.7 1.2 1.3 1 0 0 1 1 1 1 WSC domain LicD PF04991.13 PIK59559.1 - 2.3e-05 24.6 0.6 0.00063 20.0 0.1 2.6 2 1 1 3 3 3 2 LicD family Exo84_C PF16528.5 PIK59560.1 - 1.5e-40 139.2 0.6 1e-39 136.5 0.6 2.3 1 1 0 1 1 1 1 Exocyst component 84 C-terminal PH PF00169.29 PIK59560.1 - 0.0018 18.7 0.0 0.0045 17.5 0.0 1.7 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 PIK59560.1 - 0.02 14.9 0.2 0.1 12.6 0.1 2.3 1 1 1 2 2 2 0 PH domain CTP_transf_like PF01467.26 PIK59560.1 - 0.1 12.8 0.1 0.24 11.6 0.1 1.6 1 0 0 1 1 1 0 Cytidylyltransferase-like LIM PF00412.22 PIK59562.1 - 2.2e-23 82.2 19.4 2.8e-09 37.1 3.6 3.3 3 0 0 3 3 3 3 LIM domain DZR PF12773.7 PIK59562.1 - 0.013 15.5 23.1 0.079 13.0 2.8 3.8 3 2 0 3 3 3 0 Double zinc ribbon WD40 PF00400.32 PIK59563.1 - 3.1e-07 31.0 3.5 0.044 14.7 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat Exostosin PF03016.15 PIK59564.1 - 1.5e-08 34.2 0.0 1.6e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Exostosin family zf-C4 PF00105.18 PIK59565.1 - 2.3e-23 82.4 9.1 2.3e-23 82.4 9.1 1.9 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK59565.1 - 9.2e-17 61.3 0.1 1.6e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor UPF0515 PF15135.6 PIK59566.1 - 2.8e-18 66.2 21.1 1.1e-17 64.2 21.1 2.1 1 1 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC_2 PF17180.4 PIK59566.1 - 0.0013 19.4 5.2 0.0013 19.4 5.2 2.8 2 1 0 2 2 2 1 Zinc-binding domain ClpS PF02617.17 PIK59566.1 - 0.12 12.2 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS DUF1451 PF07295.11 PIK59566.1 - 0.76 9.8 7.2 0.62 10.1 1.3 2.6 1 1 1 2 2 2 0 Zinc-ribbon containing domain TackOD1 PF18551.1 PIK59566.1 - 1.4 8.6 12.7 0.13 11.9 6.9 2.0 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 Zn-ribbon_8 PF09723.10 PIK59566.1 - 4.2 7.6 18.5 0.094 12.9 1.9 3.4 3 0 0 3 3 3 0 Zinc ribbon domain Pkinase PF00069.25 PIK59567.1 - 1.8e-62 211.1 0.0 2.5e-62 210.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59567.1 - 1e-40 139.7 0.0 1.4e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59567.1 - 4.7e-05 22.8 0.0 0.0013 18.1 0.0 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK59567.1 - 0.0029 16.5 0.0 0.0054 15.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK59567.1 - 0.16 11.3 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_25 PF13649.6 PIK59568.1 - 5.2e-08 33.5 0.0 7.1e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK59568.1 - 7.2e-05 23.4 0.0 0.0001 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Fibrillarin PF01269.17 PIK59568.1 - 0.00037 19.7 0.0 0.00042 19.5 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin Methyltransf_31 PF13847.6 PIK59568.1 - 0.0005 19.9 0.0 0.00063 19.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59568.1 - 0.0025 18.5 0.0 0.0033 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59568.1 - 0.013 15.3 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 PIK59568.1 - 0.073 12.8 0.0 0.081 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 PIK59568.1 - 0.16 11.0 0.1 0.2 10.7 0.1 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 PIK59568.1 - 0.17 12.0 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 FtsJ-like methyltransferase MAP17 PF15807.5 PIK59569.1 - 0.00037 20.7 0.0 0.001 19.3 0.0 1.7 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Lectin_C PF00059.21 PIK59570.1 - 1.7e-33 115.6 7.5 3.7e-19 69.4 1.1 2.9 3 0 0 3 3 3 2 Lectin C-type domain fn3 PF00041.21 PIK59570.1 - 3.2e-29 101.1 8.5 3.6e-09 36.8 0.0 3.5 3 0 0 3 3 3 3 Fibronectin type III domain CUB PF00431.20 PIK59570.1 - 2.8e-14 53.4 0.0 4e-13 49.7 0.0 2.5 1 1 0 1 1 1 1 CUB domain Pur_ac_phosph_N PF16656.5 PIK59570.1 - 3.3e-05 24.4 10.5 0.8 10.3 0.0 4.6 3 1 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain Chordopox_A33R PF05966.12 PIK59570.1 - 0.0031 16.8 0.0 1.6 8.0 0.0 2.3 2 0 0 2 2 2 2 Chordopoxvirus A33R protein DUF2369 PF10179.9 PIK59570.1 - 0.0066 16.8 0.1 23 5.5 0.1 3.4 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) CUB PF00431.20 PIK59571.1 - 1.8e-60 202.0 0.0 5.1e-14 52.5 0.0 5.7 6 0 0 6 6 6 5 CUB domain Lectin_C PF00059.21 PIK59571.1 - 1.5e-58 196.2 20.3 3.5e-18 66.3 1.4 4.6 4 0 0 4 4 4 4 Lectin C-type domain fn3 PF00041.21 PIK59571.1 - 3e-24 85.2 1.5 2.8e-09 37.2 0.1 4.6 4 0 0 4 4 4 3 Fibronectin type III domain HAP2-GCS1 PF10699.9 PIK59571.1 - 0.00065 19.6 1.3 0.69 9.9 0.1 2.9 2 0 0 2 2 2 2 Male gamete fusion factor DUF3558 PF12079.8 PIK59571.1 - 0.0048 16.9 0.1 0.83 9.6 0.2 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3558) Lectin_C PF00059.21 PIK59572.1 - 4.7e-15 56.3 0.9 9.6e-15 55.2 0.9 1.6 1 0 0 1 1 1 1 Lectin C-type domain fn3 PF00041.21 PIK59572.1 - 6.3e-12 45.7 4.4 7.7e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Chordopox_A33R PF05966.12 PIK59573.1 - 0.0093 15.3 0.0 0.0097 15.2 0.0 1.1 1 0 0 1 1 1 1 Chordopoxvirus A33R protein Lectin_C PF00059.21 PIK59574.1 - 4.5e-11 43.4 1.2 1.2e-10 42.1 1.2 1.7 1 1 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK59575.1 - 1.5e-15 57.8 0.4 2.7e-15 57.0 0.1 1.5 2 0 0 2 2 2 1 Lectin C-type domain fn3 PF00041.21 PIK59575.1 - 0.00029 21.1 0.0 0.0006 20.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain CUB PF00431.20 PIK59575.1 - 0.001 19.4 0.0 0.0023 18.3 0.0 1.6 1 0 0 1 1 1 1 CUB domain CUB PF00431.20 PIK59576.1 - 1.7e-50 170.0 0.0 7.7e-14 52.0 0.0 4.1 4 0 0 4 4 4 4 CUB domain CUB_2 PF02408.20 PIK59576.1 - 0.041 13.6 0.2 2.5 7.9 0.0 3.3 4 0 0 4 4 4 0 CUB-like domain Lectin_C PF00059.21 PIK59577.1 - 6.7e-15 55.7 0.4 1.1e-14 55.1 0.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain fn3 PF00041.21 PIK59577.1 - 1.6e-11 44.3 0.1 2.8e-11 43.6 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CUB PF00431.20 PIK59578.1 - 1.7e-84 279.4 7.0 4.9e-17 62.3 0.0 6.6 6 0 0 6 6 6 6 CUB domain Lectin_C PF00059.21 PIK59578.1 - 4.8e-45 152.7 12.0 3.8e-16 59.8 2.8 4.5 4 0 0 4 4 4 3 Lectin C-type domain fn3 PF00041.21 PIK59578.1 - 1.2e-17 64.1 6.1 1.3e-08 35.0 0.1 3.6 4 0 0 4 4 4 2 Fibronectin type III domain Chordopox_A33R PF05966.12 PIK59578.1 - 0.0012 18.2 0.3 7.5 5.8 0.0 3.4 3 0 0 3 3 3 2 Chordopoxvirus A33R protein UL45 PF05473.12 PIK59578.1 - 0.0051 16.5 3.6 5.1 6.7 0.1 3.8 4 0 0 4 4 4 2 UL45 protein, carbohydrate-binding C-type lectin-like CUB_2 PF02408.20 PIK59578.1 - 0.019 14.7 9.7 1.6 8.5 0.0 5.0 4 1 1 5 5 5 0 CUB-like domain Pur_ac_phosph_N PF16656.5 PIK59578.1 - 0.04 14.5 7.9 4.1 8.0 0.1 4.2 3 0 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 PIK59578.1 - 0.12 12.5 0.2 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Fibronectin type III domain Pkinase PF00069.25 PIK59579.1 - 9.1e-08 31.8 0.1 0.00053 19.4 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain PAS PF00989.25 PIK59579.1 - 0.066 13.2 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 PAS fold GpcrRhopsn4 PF10192.9 PIK59580.1 - 1.3e-35 123.1 19.3 2e-35 122.5 19.3 1.3 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain GWT1 PF06423.12 PIK59580.1 - 0.0027 17.9 2.6 0.003 17.7 0.2 2.4 3 0 0 3 3 3 1 GWT1 AsnC_trans_reg2 PF17805.1 PIK59580.1 - 0.075 13.2 0.2 0.21 11.8 0.2 1.7 1 0 0 1 1 1 0 AsnC-like ligand binding domain TMEM107 PF14995.6 PIK59580.1 - 0.29 11.6 5.9 0.92 10.0 5.7 2.1 1 1 0 1 1 1 0 Transmembrane protein GpcrRhopsn4 PF10192.9 PIK59581.1 - 4.8e-41 140.9 18.6 6.7e-41 140.4 18.6 1.2 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain GWT1 PF06423.12 PIK59581.1 - 0.0029 17.7 3.2 0.0029 17.7 0.8 2.3 2 1 0 2 2 2 1 GWT1 AsnC_trans_reg2 PF17805.1 PIK59581.1 - 0.082 13.1 0.4 0.23 11.6 0.4 1.7 1 0 0 1 1 1 0 AsnC-like ligand binding domain JmjN PF02375.17 PIK59581.1 - 0.21 11.6 0.8 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 jmjN domain Adenyl_cycl_N PF12633.7 PIK59582.1 - 4.9 7.0 12.2 3 7.7 10.1 1.7 1 1 0 1 1 1 0 Adenylate cyclase NT domain Lipase_GDSL_2 PF13472.6 PIK59582.1 - 8.9 6.7 8.3 0.8 10.1 1.4 2.4 1 1 2 3 3 3 0 GDSL-like Lipase/Acylhydrolase family ABC_tran PF00005.27 PIK59583.1 - 7.7e-32 110.7 0.0 1.2e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter DEAD PF00270.29 PIK59583.1 - 0.00027 20.7 0.1 0.0005 19.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SMC_N PF02463.19 PIK59583.1 - 0.00048 19.6 0.3 0.023 14.1 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 PIK59583.1 - 0.00053 20.2 0.2 0.00099 19.3 0.2 1.4 1 0 0 1 1 1 1 Helicase HerA, central domain MeaB PF03308.16 PIK59583.1 - 0.033 13.2 0.1 0.051 12.5 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 PIK59583.1 - 0.048 12.7 0.1 0.079 12.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 PIK59583.1 - 0.065 12.6 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_21 PF13304.6 PIK59583.1 - 0.079 12.7 0.2 7.9 6.2 0.0 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 PIK59583.1 - 0.11 12.2 0.3 0.22 11.3 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 PIK59583.1 - 0.16 12.1 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase CbiA PF01656.23 PIK59583.1 - 0.18 11.8 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 PIK59583.1 - 0.19 12.3 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 PIK59584.1 - 6.4e-22 78.4 1.4 2.7e-21 76.4 0.4 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 PIK59584.1 - 0.00064 19.9 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF3450 PF11932.8 PIK59584.1 - 0.013 14.8 1.9 0.028 13.7 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SPACA9 PF15120.6 PIK59584.1 - 0.74 9.6 4.5 3.3 7.4 0.2 2.4 2 1 0 2 2 2 0 Sperm acrosome-associated protein 9 ANAPC4_WD40 PF12894.7 PIK59585.1 - 0.00035 20.8 0.0 0.078 13.3 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK59585.1 - 0.00036 21.3 5.5 0.08 13.9 0.0 4.6 4 1 0 4 4 4 1 WD domain, G-beta repeat ETF PF01012.21 PIK59586.1 - 5.2e-15 55.8 0.1 1.1e-08 35.2 0.0 2.1 2 0 0 2 2 2 2 Electron transfer flavoprotein domain ATG16 PF08614.11 PIK59587.1 - 0.0042 17.3 21.8 0.0057 16.9 21.8 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) B2 PF11473.8 PIK59587.1 - 0.044 13.6 0.7 6.6 6.6 0.1 2.3 2 0 0 2 2 2 0 RNA binding protein B2 ASD2 PF08687.11 PIK59587.1 - 0.045 13.3 16.6 0.06 12.9 16.6 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 DUF1664 PF07889.12 PIK59587.1 - 0.061 13.4 17.8 0.024 14.7 8.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Tmemb_cc2 PF10267.9 PIK59587.1 - 0.071 12.2 20.8 0.1 11.7 20.8 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Occludin_ELL PF07303.13 PIK59587.1 - 0.15 12.8 17.9 0.059 14.1 8.4 2.4 1 1 1 2 2 2 0 Occludin homology domain ThrE PF06738.12 PIK59587.1 - 0.23 10.8 4.6 0.3 10.4 3.7 1.5 1 1 0 1 1 1 0 Putative threonine/serine exporter Baculo_PEP_C PF04513.12 PIK59587.1 - 0.41 10.7 7.9 2.5 8.1 7.4 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PEP-utilisers_N PF05524.13 PIK59587.1 - 0.56 10.4 9.9 0.23 11.7 6.2 2.2 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal GAS PF13851.6 PIK59587.1 - 0.61 9.4 26.5 0.96 8.8 26.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 PIK59587.1 - 0.71 9.4 20.1 2.5 7.6 20.2 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit Prominin PF05478.11 PIK59587.1 - 0.86 7.5 12.7 1 7.2 12.7 1.1 1 0 0 1 1 1 0 Prominin Ku_C PF03730.14 PIK59587.1 - 1.1 10.0 15.5 0.12 13.1 1.2 3.1 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm DUF948 PF06103.11 PIK59587.1 - 1.1 9.5 12.0 0.15 12.4 4.3 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Cauli_DNA-bind PF03310.13 PIK59587.1 - 3.1 7.9 7.4 1.5 8.9 3.9 2.0 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein Med2 PF11214.8 PIK59587.1 - 3.3 7.9 19.6 0.25 11.5 9.2 2.9 1 1 2 3 3 3 0 Mediator complex subunit 2 T3SSipB PF16535.5 PIK59587.1 - 5.1 7.5 16.8 1.6 9.2 1.9 2.6 1 1 1 2 2 2 0 Type III cell invasion protein SipB Enolase_N PF03952.16 PIK59587.1 - 6.3 7.0 6.7 3 8.0 1.3 2.2 1 1 1 2 2 2 0 Enolase, N-terminal domain Fez1 PF06818.15 PIK59587.1 - 6.5 7.2 24.3 3.2 8.2 13.9 2.0 1 1 1 2 2 2 0 Fez1 Bac_globin PF01152.21 PIK59587.1 - 7.2 6.8 11.0 6.1 7.0 2.4 3.0 1 1 1 3 3 3 0 Bacterial-like globin LMBR1 PF04791.16 PIK59587.1 - 7.2 5.4 13.1 8.4 5.2 13.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 PIK59587.1 - 7.7 5.5 20.8 0.29 10.2 6.7 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 PIK59587.1 - 7.7 6.3 26.2 3.8 7.3 8.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) BEX PF04538.12 PIK59587.1 - 8.1 7.1 14.5 46 4.6 14.5 2.3 1 1 0 1 1 1 0 Brain expressed X-linked like family Fib_alpha PF08702.10 PIK59587.1 - 8.9 6.5 20.4 7.4 6.7 8.9 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 PIK59587.1 - 9.2 6.3 27.3 3.5 7.7 16.5 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ly49 PF08391.10 PIK59587.1 - 9.7 6.6 18.5 0.92 9.9 10.5 2.7 1 1 2 3 3 3 0 Ly49-like protein, N-terminal region DUF87 PF01935.17 PIK59587.1 - 9.9 6.2 11.9 2.4 8.2 7.4 1.8 1 1 1 2 2 2 0 Helicase HerA, central domain Beta_propel PF09826.9 PIK59588.1 - 0.014 14.2 0.0 1.2 7.9 0.0 2.3 2 1 0 2 2 2 0 Beta propeller domain Sybindin PF04099.12 PIK59589.1 - 5.2e-48 162.6 0.0 5.6e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 PIK59589.1 - 4.2e-09 36.6 0.0 5.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PDZ_6 PF17820.1 PIK59589.1 - 9.7e-05 22.1 0.2 0.00016 21.5 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK59589.1 - 0.012 16.0 0.2 0.023 15.0 0.2 1.5 1 0 0 1 1 1 0 PDZ domain Porphobil_deam PF01379.20 PIK59590.1 - 4.4e-69 232.1 0.0 7e-69 231.4 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 PIK59590.1 - 7.1e-17 61.6 1.8 1.7e-14 53.9 1.8 2.5 1 1 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF4819 PF16090.5 PIK59591.1 - 3.5e-08 33.4 2.2 1.2e-07 31.7 2.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4819) DUF4537 PF15057.6 PIK59591.1 - 0.022 14.8 0.7 0.042 13.9 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DCAF17 PF15802.5 PIK59591.1 - 0.95 8.1 3.1 1.4 7.6 3.1 1.1 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 17 HMG_box PF00505.19 PIK59592.1 - 2.4e-16 59.9 3.5 5.3e-16 58.8 3.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK59592.1 - 1.3e-06 28.9 2.4 2.5e-06 28.0 1.3 2.2 1 1 0 1 1 1 1 HMG-box domain RhoGAP PF00620.27 PIK59595.1 - 6e-45 152.8 0.0 2e-44 151.1 0.1 1.8 2 0 0 2 2 2 1 RhoGAP domain SH3_9 PF14604.6 PIK59595.1 - 1.1e-09 38.0 0.0 2.1e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK59595.1 - 2.6e-08 33.4 0.0 7e-08 32.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK59595.1 - 2e-07 30.5 0.1 6.7e-07 28.8 0.1 2.0 2 0 0 2 2 2 1 SH3 domain PX PF00787.24 PIK59595.1 - 0.00023 21.1 0.0 0.00068 19.6 0.0 1.7 1 0 0 1 1 1 1 PX domain JAB PF01398.21 PIK59595.1 - 9.3 6.3 8.2 43 4.1 1.1 4.2 1 1 1 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RRM_1 PF00076.22 PIK59596.1 - 1.7e-60 200.7 0.7 1.2e-20 73.1 0.2 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK59596.1 - 1.1e-09 38.0 0.1 0.012 15.2 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK59596.1 - 0.0001 22.3 0.0 0.39 10.8 0.1 2.5 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 PIK59596.1 - 0.00041 20.2 0.0 0.0035 17.2 0.0 2.5 3 2 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 PIK59596.1 - 0.00066 19.8 0.0 14 5.9 0.0 3.6 3 0 0 3 3 3 2 RNA recognition motif RNA_bind PF08675.11 PIK59596.1 - 0.0032 17.5 0.0 0.92 9.6 0.0 3.3 3 0 0 3 3 3 1 RNA binding domain Pepdidase_M14_N PF18027.1 PIK59597.1 - 2.9e-12 46.9 0.0 3.4e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain DUF1990 PF09348.10 PIK59597.1 - 0.096 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1990) Peptidase_M14 PF00246.24 PIK59598.1 - 4.5e-18 66.1 0.0 5e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase RNA_pol_Rpb1_5 PF04998.17 PIK59599.1 - 7.8e-96 320.6 0.0 1.3e-95 319.9 0.0 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 PIK59599.1 - 3.8e-09 36.5 1.2 1.6e-08 34.4 0.0 2.8 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 4 NOA36 PF06524.12 PIK59599.1 - 0.15 11.4 13.8 0.17 11.2 3.8 2.6 2 0 0 2 2 2 0 NOA36 protein RNA_pol_Rpb1_2 PF00623.20 PIK59600.1 - 7.1e-68 228.0 0.4 1.4e-67 227.1 0.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 PIK59600.1 - 3.6e-23 82.2 0.8 1.4e-22 80.3 0.0 2.3 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 PIK59600.1 - 0.0001 21.8 3.6 0.023 14.0 0.2 3.0 2 1 1 3 3 3 2 RNA polymerase Rpb1, domain 1 NDUF_B7 PF05676.13 PIK59601.1 - 2.9e-28 97.4 9.9 3.8e-28 97.0 9.9 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 PIK59601.1 - 0.00028 20.8 6.0 0.00044 20.2 6.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like UPF0203 PF05254.12 PIK59601.1 - 0.48 10.7 7.5 1.3 9.3 0.2 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0203) ELO PF01151.18 PIK59602.1 - 1.2e-47 162.6 27.9 5.2e-36 124.4 19.1 2.0 1 1 1 2 2 2 2 GNS1/SUR4 family CCSMST1 PF15013.6 PIK59602.1 - 1.8 8.8 9.2 1.6 9.0 0.6 2.7 3 0 0 3 3 3 0 CCSMST1 family PRCH PF03967.13 PIK59602.1 - 2 8.7 5.0 15 5.8 0.1 2.4 2 0 0 2 2 2 0 Photosynthetic reaction centre, H-chain N-terminal region ELO PF01151.18 PIK59603.1 - 2.1e-47 161.7 20.9 2.5e-47 161.5 20.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family 2OG-FeII_Oxy_3 PF13640.6 PIK59604.1 - 2.5e-13 50.7 3.6 6.7e-13 49.4 3.6 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RICTOR_V PF14668.6 PIK59608.1 - 3.3e-17 62.5 0.1 9.1e-16 57.9 0.0 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 PIK59608.1 - 3.8e-13 49.8 0.3 2.1e-11 44.1 0.0 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 PIK59608.1 - 0.038 13.8 0.0 3.6 7.4 0.0 2.3 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_N PF14664.6 PIK59609.1 - 1.1e-72 245.1 1.0 8e-72 242.3 1.0 1.9 1 1 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term Glyco_hydro_16 PF00722.21 PIK59610.1 - 6e-16 58.4 0.2 1.1e-15 57.6 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PAT1 PF09770.9 PIK59611.1 - 0.98 7.6 34.2 1.3 7.2 34.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Secretin_N_2 PF07655.13 PIK59611.1 - 5.5 7.6 10.8 8.4 7.0 5.8 3.0 2 1 0 2 2 2 0 Secretin N-terminal domain STIL_N PF15253.6 PIK59612.1 - 2.3e-53 181.6 0.3 2.8e-53 181.3 0.3 1.1 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus STIL_N PF15253.6 PIK59613.1 - 5.8e-10 38.7 0.0 6.6e-10 38.5 0.0 1.0 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus UBX PF00789.20 PIK59614.1 - 2.7e-15 56.3 0.0 7.3e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 PIK59614.1 - 1.9e-05 24.4 0.4 5.7e-05 22.8 0.4 1.8 1 0 0 1 1 1 1 UBA-like domain ubiquitin PF00240.23 PIK59614.1 - 0.0026 17.5 0.0 3.9 7.3 0.0 2.9 2 0 0 2 2 2 2 Ubiquitin family DUF724 PF05266.14 PIK59614.1 - 2.7 7.8 14.9 16 5.2 13.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF3523 PF12037.8 PIK59614.1 - 6.4 6.1 19.1 12 5.2 19.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) tRNA-synt_1c PF00749.21 PIK59614.1 - 9.2 5.0 9.9 29 3.4 9.7 1.9 1 1 1 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain EF-hand_7 PF13499.6 PIK59615.1 - 9.3e-24 83.7 24.2 2.4e-10 40.7 1.4 3.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 PIK59615.1 - 1.5e-21 74.4 5.7 7.7e-06 25.4 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 PIK59615.1 - 7e-20 69.0 13.9 4.3e-07 29.0 2.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 PIK59615.1 - 2.9e-12 45.5 12.2 0.0016 17.9 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 PIK59615.1 - 2.5e-10 40.0 14.7 3.1e-08 33.4 3.4 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 PIK59615.1 - 0.00016 21.6 0.6 0.034 14.1 0.1 2.6 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 PIK59615.1 - 0.037 14.3 0.3 8.4 6.8 0.0 3.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_M10_C PF08548.11 PIK59615.1 - 0.091 12.6 0.9 6 6.7 0.1 2.3 1 1 1 2 2 2 0 Peptidase M10 serralysin C terminal EF-hand_9 PF14658.6 PIK59615.1 - 0.095 13.0 2.2 2.9 8.3 0.3 3.8 3 1 1 4 4 4 0 EF-hand domain LSM PF01423.22 PIK59616.1 - 0.021 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 LSM domain Hfx_Cass5 PF18287.1 PIK59616.1 - 0.15 12.2 0.3 0.28 11.4 0.3 1.5 1 1 0 1 1 1 0 Integron Cassette Protein Hfx_Cass5 XPC-binding PF09280.11 PIK59617.1 - 7.4e-15 54.4 8.0 1.3e-14 53.7 8.0 1.3 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 PIK59617.1 - 3.2e-14 52.4 0.0 6.7e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 PIK59617.1 - 1.8e-11 43.7 1.3 3.2e-11 42.9 1.3 1.4 1 0 0 1 1 1 1 UBA/TS-N domain DUF2407 PF10302.9 PIK59617.1 - 0.0003 21.3 0.0 0.0006 20.3 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 PIK59617.1 - 0.00033 20.7 0.0 0.00068 19.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Hamartin PF04388.12 PIK59617.1 - 4.7 5.8 8.5 5.3 5.6 8.5 1.1 1 0 0 1 1 1 0 Hamartin protein 2OG-FeII_Oxy_3 PF13640.6 PIK59618.1 - 3.5e-15 56.7 0.3 2.9e-13 50.5 0.3 2.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_6 PF13405.6 PIK59618.1 - 0.064 13.2 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Peptidase_C14 PF00656.22 PIK59618.1 - 0.087 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Caspase domain 2OG-FeII_Oxy PF03171.20 PIK59618.1 - 0.2 12.2 0.5 1.3 9.5 0.5 2.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily URO-D PF01208.17 PIK59619.1 - 2.3e-103 346.0 0.0 2.7e-103 345.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) HOOK PF05622.12 PIK59620.1 - 2.9e-61 207.5 0.1 3.6e-61 207.3 0.1 1.0 1 0 0 1 1 1 1 HOOK protein DUF903 PF06004.12 PIK59620.1 - 0.047 13.6 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) FAA_hydrolase_N PF09298.11 PIK59620.1 - 0.17 12.1 0.3 1.5 9.1 0.0 2.2 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal HOOK PF05622.12 PIK59621.1 - 1.5e-46 158.9 18.2 1.8e-46 158.7 18.2 1.0 1 0 0 1 1 1 1 HOOK protein Tropomyosin PF00261.20 PIK59621.1 - 5.4e-05 22.7 19.4 0.019 14.3 9.0 2.1 2 0 0 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 PIK59621.1 - 0.00099 19.3 21.1 0.067 13.3 2.6 2.2 2 0 0 2 2 2 2 Tropomyosin like GAS PF13851.6 PIK59621.1 - 0.0048 16.3 24.4 0.16 11.3 4.2 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 PIK59621.1 - 0.007 16.5 14.2 0.007 16.5 14.2 1.7 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus KASH_CCD PF14662.6 PIK59621.1 - 0.016 15.1 21.6 0.27 11.1 9.9 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF4472 PF14739.6 PIK59621.1 - 0.024 15.4 17.9 0.49 11.1 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 PIK59621.1 - 0.036 14.6 9.7 0.036 14.6 9.7 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region CALCOCO1 PF07888.11 PIK59621.1 - 0.066 12.1 23.3 0.39 9.5 5.9 2.0 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like NBP1 PF08537.10 PIK59621.1 - 0.24 10.8 18.2 1.4 8.3 18.2 1.9 1 1 0 1 1 1 0 Fungal Nap binding protein NBP1 Npun_R1517 PF18068.1 PIK59621.1 - 0.25 11.7 4.1 4.6 7.6 0.6 2.6 2 0 0 2 2 2 0 Npun R1517 DUF4407 PF14362.6 PIK59621.1 - 0.36 10.1 11.3 0.48 9.7 4.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2514 PF10721.9 PIK59621.1 - 0.38 10.8 4.4 3.7 7.6 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) COG6 PF06419.11 PIK59621.1 - 0.4 8.8 10.0 0.014 13.6 4.0 1.5 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 DUF641 PF04859.12 PIK59621.1 - 0.51 10.7 16.6 0.25 11.7 1.9 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Golgin_A5 PF09787.9 PIK59621.1 - 0.55 9.6 23.4 0.26 10.7 8.7 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF4200 PF13863.6 PIK59621.1 - 0.56 10.6 21.9 2.3 8.6 9.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 PIK59621.1 - 0.73 10.0 24.3 0.35 11.1 8.9 2.4 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Herpes_BLRF2 PF05812.12 PIK59621.1 - 1.1 9.4 10.8 0.15 12.2 1.6 2.5 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein ERM PF00769.19 PIK59621.1 - 1.1 9.0 29.0 2 8.2 7.4 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family BST2 PF16716.5 PIK59621.1 - 2.3 8.9 18.9 0.54 10.9 1.1 3.2 2 2 1 3 3 3 0 Bone marrow stromal antigen 2 Spc7 PF08317.11 PIK59621.1 - 2.7 6.8 23.5 1.5 7.6 10.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 PIK59621.1 - 2.7 7.2 16.0 0.89 8.8 6.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) HALZ PF02183.18 PIK59621.1 - 4.5 7.6 10.5 1.5 9.1 3.0 3.5 3 1 0 3 3 3 0 Homeobox associated leucine zipper DUF4140 PF13600.6 PIK59621.1 - 4.6 7.7 11.7 1.6 9.2 4.8 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FapA PF03961.13 PIK59621.1 - 5.1 5.6 15.2 1.1 7.7 2.9 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Fez1 PF06818.15 PIK59621.1 - 5.4 7.4 22.9 98 3.3 22.5 2.0 1 1 0 1 1 1 0 Fez1 NPV_P10 PF05531.12 PIK59621.1 - 5.7 7.5 9.3 19 5.8 3.6 3.2 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 PIK59621.1 - 5.8 5.9 17.0 4.3 6.3 5.5 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSC22 PF01166.18 PIK59621.1 - 6 7.3 16.5 2.6 8.4 3.3 3.6 3 1 1 4 4 4 0 TSC-22/dip/bun family Fungal_TACC PF12709.7 PIK59621.1 - 8.9 6.8 19.2 0.91 10.0 4.1 3.4 2 2 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4201 PF13870.6 PIK59621.1 - 9.2 6.0 22.6 0.15 11.7 8.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Tho2 PF11262.8 PIK59621.1 - 9.3 5.4 14.0 0.1 11.8 4.0 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Csm1_N PF18504.1 PIK59621.1 - 9.6 6.6 21.6 11 6.4 2.3 3.7 2 2 1 3 3 3 0 Csm1 N-terminal domain Pkinase_Tyr PF07714.17 PIK59622.1 - 2.3e-05 23.8 0.0 3.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK59622.1 - 3.5e-05 23.3 0.0 5.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF3261 PF11659.8 PIK59622.1 - 0.042 13.7 0.9 11 5.8 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3261) Tctex-1 PF03645.13 PIK59623.1 - 7.6e-24 83.9 0.0 1.2e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Tctex-1 family EGF PF00008.27 PIK59624.1 - 7.5e-05 22.9 4.8 7.5e-05 22.9 4.8 2.8 2 1 0 2 2 2 2 EGF-like domain FXa_inhibition PF14670.6 PIK59624.1 - 0.023 14.9 1.7 0.023 14.9 1.7 2.4 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site hEGF PF12661.7 PIK59624.1 - 0.036 14.7 3.7 0.036 14.7 3.7 2.9 3 0 0 3 3 3 0 Human growth factor-like EGF Laminin_G_2 PF02210.24 PIK59625.1 - 2.4e-05 24.9 0.0 2.8e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK59625.1 - 0.00078 19.7 0.0 0.00078 19.7 0.0 1.0 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 PIK59626.1 - 4.7e-59 198.3 0.0 9.4e-27 93.8 0.0 3.1 3 0 0 3 3 3 3 Laminin G domain Laminin_G_2 PF02210.24 PIK59626.1 - 1.4e-58 196.9 0.2 1.7e-26 93.3 0.1 3.1 3 0 0 3 3 3 3 Laminin G domain EGF PF00008.27 PIK59626.1 - 7.1e-08 32.6 23.9 0.00074 19.8 7.0 2.6 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 PIK59626.1 - 7.8e-07 29.5 16.9 0.00042 20.8 3.9 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 PIK59626.1 - 0.14 12.5 25.2 1.1 9.7 8.1 2.5 2 0 0 2 2 2 0 EGF-like domain GNT-I PF03071.15 PIK59627.1 - 6.5e-49 166.9 1.0 1.8e-48 165.4 1.0 1.6 1 1 0 1 1 1 1 GNT-I family ILEI PF15711.5 PIK59627.1 - 3.3e-25 88.4 0.1 7.2e-25 87.3 0.1 1.6 1 0 0 1 1 1 1 Interleukin-like EMT inducer MGAT2 PF05060.14 PIK59627.1 - 2.4e-06 26.8 0.1 0.0096 15.0 0.1 2.2 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Fibrinogen_C PF00147.18 PIK59628.1 - 7.7e-64 215.5 7.8 8.7e-64 215.3 7.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK59628.1 - 0.018 14.4 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain rve PF00665.26 PIK59629.1 - 3e-24 85.5 0.0 4.7e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK59629.1 - 6.9e-09 35.4 0.1 2.1e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 PIK59629.1 - 0.0017 18.4 0.0 0.0037 17.3 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve PF00665.26 PIK59630.1 - 2.2e-19 69.8 0.0 3.9e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59630.1 - 1.1e-17 63.9 0.0 1.7e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK59630.1 - 9.9e-07 28.9 0.0 1.9e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK59630.1 - 0.00036 20.2 0.0 0.00075 19.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK59631.1 - 2.6e-27 94.8 0.0 4.9e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK59631.1 - 3.3e-22 78.8 0.0 6e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK59631.1 - 1.5e-15 57.3 0.0 2.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 PIK59631.1 - 0.03 14.1 0.0 0.51 10.2 0.0 2.2 2 0 0 2 2 2 0 Reverse transcriptase-like Thiolase_N PF00108.23 PIK59632.1 - 1e-64 218.4 1.2 4.2e-61 206.6 1.0 2.4 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK59632.1 - 6.9e-47 158.1 0.0 1.4e-46 157.1 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 PIK59632.1 - 1.4e-05 24.8 0.5 3e-05 23.7 0.5 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ECH_1 PF00378.20 PIK59633.1 - 3.1e-28 98.7 0.1 8.8e-27 94.0 0.1 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK59633.1 - 1.3e-18 67.7 0.0 1.5e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase AMA-1 PF02430.15 PIK59633.1 - 0.21 10.5 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 3HCDH_N PF02737.18 PIK59634.1 - 3.9e-53 180.0 1.5 3.9e-53 180.0 1.5 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 PIK59634.1 - 1.7e-33 115.1 0.2 1.4e-25 89.7 0.1 2.8 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Acyltransf_C PF16076.5 PIK59635.1 - 2.4e-16 59.6 0.0 4.1e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase C-terminus Fibrinogen_C PF00147.18 PIK59636.1 - 2.3e-21 76.6 0.2 9.5e-13 48.5 0.0 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59636.1 - 1.5e-05 25.1 5.8 1.5e-05 25.1 5.8 3.2 2 1 1 3 3 3 1 EGF domain TILa PF12714.7 PIK59636.1 - 0.0014 18.6 4.6 0.0014 18.6 4.6 2.4 1 1 1 2 2 2 1 TILa domain EGF_2 PF07974.13 PIK59636.1 - 2.8 8.4 18.9 0.5 10.8 5.8 3.3 2 2 0 2 2 2 0 EGF-like domain EGF_3 PF12947.7 PIK59637.1 - 4.6e-12 45.9 58.5 7.2e-06 26.1 10.5 5.7 3 3 2 5 5 5 3 EGF domain TILa PF12714.7 PIK59637.1 - 4.9e-06 26.4 34.8 0.00035 20.5 1.5 4.5 4 1 1 5 5 5 3 TILa domain EGF_2 PF07974.13 PIK59637.1 - 0.00021 21.6 40.5 0.011 16.1 7.6 4.3 4 0 0 4 4 4 3 EGF-like domain EGF_MSP1_1 PF12946.7 PIK59637.1 - 0.00046 20.2 30.9 0.011 15.8 2.9 5.1 6 0 0 6 6 6 3 MSP1 EGF domain 1 DUF3740 PF12548.8 PIK59637.1 - 1.6 9.1 12.8 7.9 6.9 0.8 3.3 1 1 2 3 3 3 0 Sulfatase protein DUF406 PF04175.12 PIK59637.1 - 2.1 8.9 5.0 10 6.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF406) Fibrinogen_C PF00147.18 PIK59638.1 - 1.6e-56 191.5 13.6 1.9e-54 184.8 13.6 2.1 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59638.1 - 0.00028 21.0 10.3 0.00028 21.0 10.3 3.1 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK59638.1 - 0.013 15.4 2.6 0.013 15.4 2.6 2.6 3 0 0 3 3 3 0 TILa domain EGF_2 PF07974.13 PIK59638.1 - 0.095 13.1 6.1 0.47 10.9 5.9 2.5 1 1 0 1 1 1 0 EGF-like domain Fibrinogen_C PF00147.18 PIK59640.1 - 4.4e-24 85.5 9.3 3.7e-21 76.0 9.3 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59641.1 - 7.4e-32 110.9 0.9 1.1e-31 110.4 0.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK59641.1 - 6 7.2 11.9 0.27 11.5 6.3 1.7 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK59643.1 - 3.9e-06 27.0 5.9 3.9e-06 27.0 5.9 3.7 4 0 0 4 4 4 1 EGF domain TILa PF12714.7 PIK59643.1 - 2.7e-05 24.0 4.9 2.7e-05 24.0 4.9 2.6 1 1 1 2 2 2 1 TILa domain Fibrinogen_C PF00147.18 PIK59643.1 - 0.00018 21.4 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 PIK59643.1 - 1.5 9.3 20.7 1.1 9.6 6.9 3.7 3 1 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK59644.1 - 2e-43 148.8 0.2 3e-43 148.2 0.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59644.1 - 0.001 19.0 4.4 0.001 19.0 4.4 3.8 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59644.1 - 0.0025 17.9 13.6 0.0025 17.9 13.6 3.9 3 1 0 3 3 3 1 EGF domain EGF_2 PF07974.13 PIK59644.1 - 2.8 8.4 24.6 0.4 11.1 5.8 4.5 2 2 1 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK59645.1 - 5e-56 190.0 12.9 1.2e-53 182.2 12.9 2.2 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59645.1 - 6.7e-05 22.8 4.6 6.7e-05 22.8 4.6 3.9 2 1 2 4 4 4 1 TILa domain EGF_3 PF12947.7 PIK59645.1 - 0.00011 22.4 10.0 0.00011 22.4 10.0 3.7 3 1 1 4 4 4 1 EGF domain Fibrinogen_C PF00147.18 PIK59646.1 - 1e-62 211.8 28.1 1.5e-34 119.8 0.3 4.3 2 1 2 4 4 4 4 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59646.1 - 9.9e-07 28.9 5.1 9.9e-07 28.9 5.1 3.9 4 0 0 4 4 4 1 EGF domain TIL PF01826.17 PIK59646.1 - 0.016 15.4 10.5 0.016 15.4 10.5 3.8 3 1 0 3 3 3 0 Trypsin Inhibitor like cysteine rich domain Arfaptin PF06456.13 PIK59648.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 Arfaptin-like domain Fibrinogen_C PF00147.18 PIK59649.1 - 5.8e-31 108.0 0.1 7.8e-31 107.6 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK59649.1 - 0.02 14.4 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK59650.1 - 1.9e-06 28.1 0.0 4.7e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK59650.1 - 0.00089 19.8 0.0 0.0018 18.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 PIK59650.1 - 0.045 13.2 0.1 0.083 12.4 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) NACHT PF05729.12 PIK59652.1 - 2e-08 34.4 0.0 4.6e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK59652.1 - 0.0021 17.7 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK59652.1 - 0.066 13.6 0.0 0.37 11.2 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AMOP PF03782.17 PIK59655.1 - 8.7e-16 58.3 6.3 5.6e-15 55.7 6.3 2.1 1 1 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK59655.1 - 0.004 17.4 0.0 0.018 15.3 0.0 2.1 3 0 0 3 3 3 1 von Willebrand factor type D domain Galactosyl_T PF01762.21 PIK59656.1 - 7.8e-30 104.2 0.0 8.4e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Galactosyltransferase AMOP PF03782.17 PIK59657.1 - 3.1e-16 59.8 6.4 3e-15 56.6 6.4 2.3 1 1 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK59657.1 - 0.0074 16.6 0.0 0.02 15.1 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type D domain VWD PF00094.25 PIK59658.1 - 1.1e-15 58.3 0.0 1.9e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain Sushi PF00084.20 PIK59658.1 - 8.1e-10 39.2 0.2 1.9e-09 37.9 0.2 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) AMOP PF03782.17 PIK59658.1 - 0.0016 18.5 0.4 0.0029 17.7 0.4 1.4 1 0 0 1 1 1 1 AMOP domain DUF4690 PF15756.5 PIK59658.1 - 0.14 12.7 3.9 0.44 11.2 3.9 1.8 1 0 0 1 1 1 0 Small Novel Rich in Cartilage IgGFc_binding PF17517.2 PIK59659.1 - 4.8e-36 124.5 5.7 5.5e-36 124.3 5.7 1.0 1 0 0 1 1 1 1 IgGFc binding protein Glyco_hydro_65C PF03633.15 PIK59660.1 - 0.02 14.8 0.1 1.8 8.6 0.0 2.5 1 1 1 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain IgGFc_binding PF17517.2 PIK59661.1 - 6.1e-09 35.6 0.7 3.5e-05 23.2 0.0 3.1 2 1 1 3 3 3 3 IgGFc binding protein VWD PF00094.25 PIK59662.1 - 3.6e-07 30.6 0.0 6.1e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain FWWh PF14922.6 PIK59663.1 - 4.8e-41 140.1 0.9 7.7e-41 139.5 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function RSD-2 PF07547.13 PIK59663.1 - 0.023 15.2 0.3 0.059 13.9 0.1 1.7 2 0 0 2 2 2 0 RSD-2 N-terminal domain DUF2681 PF10883.8 PIK59664.1 - 0.0076 16.6 4.7 0.071 13.5 0.1 2.5 1 1 2 3 3 3 2 Protein of unknown function (DUF2681) DUF2140 PF09911.9 PIK59664.1 - 0.072 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) RT_RNaseH PF17917.1 PIK59666.1 - 2e-05 24.8 0.1 8.3e-05 22.8 0.1 1.9 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK59666.1 - 0.0037 17.1 0.1 0.0061 16.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK59666.1 - 0.046 13.7 0.1 0.2 11.7 0.1 2.0 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Branch PF02485.21 PIK59667.1 - 9e-28 97.4 0.3 2.1e-27 96.2 0.3 1.6 1 1 0 1 1 1 1 Core-2/I-Branching enzyme Xylo_C PF12529.8 PIK59667.1 - 8.9e-10 38.5 0.1 1.4e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal RF-1 PF00472.20 PIK59668.1 - 1.1e-22 80.1 3.3 1.8e-22 79.4 3.3 1.2 1 0 0 1 1 1 1 RF-1 domain DUF2856 PF11043.8 PIK59668.1 - 0.074 13.2 0.4 0.18 12.0 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) G10 PF01125.17 PIK59668.1 - 0.081 12.7 1.2 0.14 11.9 1.2 1.3 1 0 0 1 1 1 0 G10 protein DUF3283 PF11686.8 PIK59668.1 - 0.096 12.6 1.1 0.18 11.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3283) Septin PF00735.18 PIK59669.1 - 1.4e-49 168.9 1.0 2.5e-49 168.1 1.0 1.4 1 1 0 1 1 1 1 Septin DUF4549 PF15082.6 PIK59669.1 - 0.1 12.4 0.1 5.9 6.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) Septin PF00735.18 PIK59670.1 - 2.2e-44 151.8 0.0 2.8e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 PIK59670.1 - 7.2e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 PIK59670.1 - 2e-05 24.5 0.4 7e-05 22.8 0.4 1.8 1 1 0 1 1 1 1 RsgA GTPase AIG1 PF04548.16 PIK59670.1 - 3e-05 23.5 0.0 3.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 AIG1 family AAA_16 PF13191.6 PIK59670.1 - 8.5e-05 23.0 0.0 0.00011 22.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain Dynamin_N PF00350.23 PIK59670.1 - 0.00076 19.6 0.5 0.095 12.7 0.2 2.2 1 1 1 2 2 2 1 Dynamin family T2SSE PF00437.20 PIK59670.1 - 0.0021 17.2 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 PIK59670.1 - 0.0031 17.8 0.0 0.0054 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 PIK59670.1 - 0.0052 17.0 0.0 0.0088 16.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 PIK59670.1 - 0.007 16.9 0.1 0.0094 16.5 0.1 1.4 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 PIK59670.1 - 0.0089 15.7 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 PIK59670.1 - 0.0097 16.1 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 PIK59670.1 - 0.012 15.4 0.0 0.018 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 PIK59670.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 PIK59670.1 - 0.015 14.9 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 PIK59670.1 - 0.042 14.2 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase GTP_EFTU PF00009.27 PIK59670.1 - 0.048 13.2 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ras PF00071.22 PIK59670.1 - 0.05 13.2 0.0 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Ras family FtsK_SpoIIIE PF01580.18 PIK59670.1 - 0.055 12.8 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.20 PIK59670.1 - 0.059 12.5 0.1 0.2 10.8 0.0 1.7 1 1 1 2 2 2 0 G-protein alpha subunit Sigma54_activat PF00158.26 PIK59670.1 - 0.061 13.0 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_32 PF13654.6 PIK59670.1 - 0.063 12.1 0.0 0.081 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 PIK59670.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain DUF815 PF05673.13 PIK59670.1 - 0.098 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Pox_A32 PF04665.12 PIK59670.1 - 0.1 12.1 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein IstB_IS21 PF01695.17 PIK59670.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 PIK59670.1 - 0.13 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Guanylate_kin PF00625.21 PIK59670.1 - 0.14 11.9 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 Guanylate kinase IIGP PF05049.13 PIK59670.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) NACHT PF05729.12 PIK59670.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SGT1 PF07093.11 PIK59671.1 - 1.3e-181 605.0 0.5 1.5e-181 604.8 0.5 1.0 1 0 0 1 1 1 1 SGT1 protein Csm1_N PF18504.1 PIK59672.1 - 0.041 14.2 0.3 0.041 14.2 0.3 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain DivIC PF04977.15 PIK59672.1 - 0.92 9.3 8.3 5.1 6.9 3.3 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF5320 PF17253.2 PIK59672.1 - 2 9.5 5.8 14 6.8 0.2 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) SIKE PF05769.11 PIK59673.1 - 0.0063 16.5 0.3 0.0069 16.3 0.3 1.2 1 0 0 1 1 1 1 SIKE family BicD PF09730.9 PIK59673.1 - 0.013 14.0 0.7 0.015 13.8 0.7 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D Latarcin PF10279.9 PIK59673.1 - 0.026 14.9 0.4 0.037 14.4 0.4 1.2 1 0 0 1 1 1 0 Latarcin precursor DMPK_coil PF08826.10 PIK59673.1 - 0.036 14.2 1.8 0.055 13.6 1.8 1.3 1 0 0 1 1 1 0 DMPK coiled coil domain like GrpE PF01025.19 PIK59673.1 - 0.068 12.8 0.7 0.083 12.5 0.2 1.4 2 0 0 2 2 2 0 GrpE V-SNARE PF05008.15 PIK59673.1 - 0.071 13.5 1.3 0.099 13.0 1.3 1.2 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF848 PF05852.11 PIK59673.1 - 0.073 13.2 1.1 0.086 13.0 1.1 1.1 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Filament PF00038.21 PIK59674.1 - 1.8e-05 24.5 35.8 0.00011 21.9 8.9 3.0 1 1 2 3 3 3 2 Intermediate filament protein Fib_alpha PF08702.10 PIK59674.1 - 0.0021 18.3 5.1 0.0021 18.3 5.1 3.0 1 1 2 3 3 3 1 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 PIK59674.1 - 0.0034 16.9 39.5 0.064 12.7 19.6 2.3 1 1 1 2 2 2 2 Golgin subfamily A member 5 IFT20 PF14931.6 PIK59674.1 - 0.0092 16.1 5.2 0.0092 16.1 5.2 4.2 1 1 2 3 3 3 1 Intraflagellar transport complex B, subunit 20 SHE3 PF17078.5 PIK59674.1 - 0.018 14.8 31.8 0.043 13.5 0.8 4.6 1 1 4 5 5 5 0 SWI5-dependent HO expression protein 3 HMMR_N PF15905.5 PIK59674.1 - 0.02 14.4 38.4 0.13 11.7 19.1 2.3 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF641 PF04859.12 PIK59674.1 - 0.034 14.5 0.2 0.034 14.5 0.2 5.0 1 1 4 5 5 5 0 Plant protein of unknown function (DUF641) Fez1 PF06818.15 PIK59674.1 - 0.094 13.2 37.4 1.5 9.3 17.6 2.5 1 1 1 2 2 2 0 Fez1 DUF4200 PF13863.6 PIK59674.1 - 0.095 13.1 45.3 0.17 12.3 15.7 4.6 1 1 3 4 4 4 0 Domain of unknown function (DUF4200) Prominin PF05478.11 PIK59674.1 - 0.45 8.4 10.6 0.94 7.3 9.6 1.7 1 1 1 2 2 2 0 Prominin CENP-F_leu_zip PF10473.9 PIK59674.1 - 0.7 9.9 38.4 0.26 11.3 4.1 3.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Bacillus_HBL PF05791.11 PIK59674.1 - 1.3 8.8 13.7 4.6 7.0 1.9 3.5 1 1 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) CorA PF01544.18 PIK59674.1 - 1.5 8.1 24.8 0.94 8.7 8.7 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein PKcGMP_CC PF16808.5 PIK59674.1 - 1.6 8.6 41.2 0.3 11.0 0.6 6.9 5 1 2 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HIP1_clath_bdg PF16515.5 PIK59674.1 - 2 9.1 33.4 24 5.6 0.0 4.3 1 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 PIK59674.1 - 4.7 6.5 29.0 37 3.5 4.5 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 PIK59674.1 - 7.3 6.7 35.3 1.8 8.6 10.6 3.4 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Forkhead PF00250.18 PIK59675.1 - 4.3e-41 139.1 0.1 7.6e-41 138.3 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Glycos_transf_2 PF00535.26 PIK59676.1 - 2.3e-12 47.1 0.0 4.1e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 PIK59676.1 - 0.00011 21.8 0.0 0.026 14.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 PIK59676.1 - 0.00037 20.4 0.0 0.041 13.8 0.0 2.1 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 PIK59676.1 - 0.0052 17.3 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 LCM PF04072.14 PIK59677.1 - 4.5e-31 108.2 0.0 2e-30 106.1 0.0 1.9 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase KASH_CCD PF14662.6 PIK59678.1 - 0.00026 20.9 10.6 0.00026 20.9 10.6 3.2 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH ZapB PF06005.12 PIK59678.1 - 0.027 14.9 1.5 0.027 14.9 1.5 5.6 4 1 0 4 4 4 0 Cell division protein ZapB TSC22 PF01166.18 PIK59678.1 - 0.034 14.5 9.9 0.32 11.3 1.5 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family YabA PF06156.13 PIK59678.1 - 0.076 13.7 28.6 0.052 14.2 1.2 5.0 2 1 2 4 4 4 0 Initiation control protein YabA Glyco_transf_10 PF00852.19 PIK59679.1 - 1.4e-47 161.7 0.1 1.8e-47 161.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 PIK59680.1 - 1.8e-47 161.3 0.2 2.7e-47 160.8 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59680.1 - 0.0044 17.5 0.0 0.009 16.4 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59681.1 - 6.3e-30 104.2 0.2 1.3e-29 103.2 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59681.1 - 1.5e-08 35.0 0.0 3.7e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal rve PF00665.26 PIK59682.1 - 1e-21 77.3 0.0 1.4e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain 2_5_RNA_ligase2 PF13563.6 PIK59682.1 - 0.0029 17.5 0.0 0.0035 17.2 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily rve_3 PF13683.6 PIK59682.1 - 0.019 14.7 0.0 0.05 13.4 0.0 1.8 1 1 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 PIK59683.1 - 3.4e-20 72.5 0.0 6.3e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK59683.1 - 2.9e-05 24.0 0.1 5e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Flu_PB1 PF00602.17 PIK59683.1 - 0.078 11.1 0.0 0.099 10.7 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Spuma_A9PTase PF03539.14 PIK59684.1 - 0.005 17.0 0.1 0.016 15.4 0.0 1.7 1 1 1 2 2 2 1 Spumavirus aspartic protease (A9) tRNA_bind_4 PF18490.1 PIK59684.1 - 0.064 13.0 0.3 0.21 11.4 0.1 1.8 1 1 1 2 2 2 0 tRNA-binding domain DUF1759 PF03564.15 PIK59685.1 - 0.0025 17.8 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Retrotrans_gag PF03732.17 PIK59685.1 - 0.0034 17.6 0.1 0.0068 16.7 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon gag protein PNMA PF14893.6 PIK59685.1 - 0.014 14.8 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 PNMA Glyco_transf_10 PF00852.19 PIK59686.1 - 1.9e-46 158.0 1.5 2.7e-46 157.5 1.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59686.1 - 4.3e-05 23.9 0.0 8.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DUF3343 PF11823.8 PIK59686.1 - 0.044 13.2 0.1 0.49 9.9 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3343) Ion_trans_2 PF07885.16 PIK59687.1 - 5e-33 112.9 18.4 8e-18 64.2 6.6 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 PIK59687.1 - 4.8e-06 26.0 13.5 0.00086 18.6 0.2 2.4 2 1 0 2 2 2 2 Ion transport protein Lig_chan PF00060.26 PIK59687.1 - 0.014 15.3 0.4 0.034 14.0 0.0 2.0 2 1 0 2 2 2 0 Ligand-gated ion channel DUF378 PF04070.12 PIK59687.1 - 0.093 12.6 1.9 0.1 12.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF378) DXP_redisom_C PF08436.12 PIK59687.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain IRK PF01007.20 PIK59687.1 - 0.28 11.0 10.7 0.45 10.3 0.1 2.8 3 1 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain Glyco_transf_10 PF00852.19 PIK59688.1 - 4.7e-24 85.1 0.0 7.6e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59688.1 - 6.1e-07 29.9 0.0 1.2e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK59689.1 - 7.3e-19 68.1 0.0 1.5e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK59689.1 - 2.3e-05 24.8 0.1 5.2e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal PH PF00169.29 PIK59690.1 - 3.7e-06 27.4 0.0 8.7e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 PIK59690.1 - 0.013 15.6 0.2 0.042 13.9 0.2 1.9 1 1 0 1 1 1 0 PH domain PH_2 PF08458.10 PIK59690.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Linker_histone PF00538.19 PIK59691.1 - 8.3e-28 96.6 0.4 8.3e-28 96.6 0.4 2.0 2 0 0 2 2 2 1 linker histone H1 and H5 family WcbI PF18588.1 PIK59691.1 - 0.088 12.4 0.2 7.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis enzyme WcbI fn3_4 PF16794.5 PIK59692.1 - 2.2e-26 91.7 0.0 5.1e-26 90.6 0.0 1.6 1 0 0 1 1 1 1 Fibronectin-III type domain fn3 PF00041.21 PIK59692.1 - 0.026 14.9 0.0 0.12 12.7 0.0 2.2 1 0 0 1 1 1 0 Fibronectin type III domain HIP1_clath_bdg PF16515.5 PIK59693.1 - 0.042 14.5 6.7 0.042 14.5 6.7 1.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fibrinogen_C PF00147.18 PIK59694.1 - 3e-29 102.4 1.3 8.5e-26 91.1 0.9 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59695.1 - 4.9e-33 114.8 1.8 5.5e-33 114.6 1.2 1.4 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59695.1 - 9.7e-07 28.9 10.6 9.7e-07 28.9 10.6 4.3 3 1 1 4 4 4 1 EGF domain TILa PF12714.7 PIK59695.1 - 5.9e-06 26.1 6.8 5.9e-06 26.1 6.8 4.0 2 2 1 3 3 3 1 TILa domain cEGF PF12662.7 PIK59695.1 - 0.024 14.6 21.3 0.12 12.4 0.4 4.2 3 1 0 3 3 3 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK59696.1 - 9.7e-37 126.9 0.2 5.9e-34 117.8 0.4 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59696.1 - 1.4e-07 31.4 7.5 1.4e-07 31.4 7.5 3.5 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK59696.1 - 0.00054 20.1 11.8 0.00054 20.1 11.8 4.3 4 1 1 5 5 5 1 EGF domain cEGF PF12662.7 PIK59696.1 - 0.16 11.9 0.5 0.16 11.9 0.5 5.0 4 1 0 4 4 4 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK59697.1 - 5.3e-51 173.5 1.0 9.5e-25 87.7 0.1 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain DUF3805 PF12712.7 PIK59697.1 - 1.9 8.6 4.9 3.1 7.9 0.8 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3805) Fibrinogen_C PF00147.18 PIK59698.1 - 3.7e-40 138.1 11.3 2.8e-39 135.2 11.3 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TMEM251 PF15190.6 PIK59698.1 - 0.35 10.8 0.8 11 5.9 0.3 2.1 2 0 0 2 2 2 0 Transmembrane protein 251 Fibrinogen_C PF00147.18 PIK59699.1 - 1.5e-71 240.7 3.1 6.4e-35 121.0 0.3 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59699.1 - 1.6e-07 31.1 5.3 1.6e-07 31.1 5.3 3.1 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59699.1 - 5.7e-06 26.4 9.6 5.7e-06 26.4 9.6 4.3 3 1 1 4 4 4 1 EGF domain DUF1293 PF06950.11 PIK59699.1 - 0.15 12.2 0.0 3.3 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1293) cEGF PF12662.7 PIK59699.1 - 0.35 10.8 23.5 0.2 11.6 0.4 4.5 3 1 0 3 3 3 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK59700.1 - 2.8e-28 99.3 12.6 4.5e-28 98.6 12.6 1.3 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59701.1 - 5.1e-36 124.6 0.2 5.7e-36 124.4 0.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59702.1 - 1.6e-41 142.5 0.7 2e-41 142.2 0.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59703.1 - 2.6e-60 203.9 1.7 1.2e-34 120.1 0.3 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59703.1 - 1.9e-07 30.9 7.4 1.9e-07 30.9 7.4 3.3 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59703.1 - 0.00073 19.7 11.8 0.00073 19.7 11.8 4.1 4 1 1 5 5 5 1 EGF domain DUF1293 PF06950.11 PIK59703.1 - 0.074 13.2 0.0 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1293) DUF3805 PF12712.7 PIK59703.1 - 0.44 10.7 3.6 3.3 7.9 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3805) Fibrinogen_C PF00147.18 PIK59704.1 - 4.9e-36 124.6 0.2 5.5e-36 124.4 0.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59705.1 - 1.8e-18 67.2 0.1 2.2e-18 66.9 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59706.1 - 1.2e-27 97.1 17.2 3.5e-27 95.6 17.2 1.6 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain NADH-G_4Fe-4S_3 PF10588.9 PIK59706.1 - 1.2 8.7 5.7 10 5.7 2.6 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fibrinogen_C PF00147.18 PIK59707.1 - 5.8e-31 108.0 0.1 7.1e-31 107.7 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59708.1 - 8.1e-72 241.6 2.9 6.3e-36 124.3 0.1 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59708.1 - 2.9e-06 27.1 7.4 2.9e-06 27.1 7.4 3.6 1 1 1 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK59708.1 - 0.00055 20.1 11.2 0.00055 20.1 11.2 4.8 4 1 1 5 5 5 1 EGF domain Calcyon PF06387.11 PIK59708.1 - 0.083 12.9 0.6 0.14 12.2 0.6 1.3 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) cEGF PF12662.7 PIK59708.1 - 0.099 12.6 0.3 0.099 12.6 0.3 4.7 4 1 0 4 4 4 0 Complement Clr-like EGF-like Fibrinogen_C PF00147.18 PIK59709.1 - 5e-39 134.4 1.8 1.1e-25 90.7 0.2 2.2 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59709.1 - 1.1e-10 41.3 11.7 1.1e-10 41.3 11.7 3.8 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK59709.1 - 2.7e-05 24.3 15.2 2.7e-05 24.3 15.2 3.2 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK59709.1 - 0.00038 20.6 9.5 0.00038 20.6 9.5 4.5 3 1 0 3 3 3 1 EGF domain Kelch_1 PF01344.25 PIK59710.1 - 8.9e-14 50.8 0.2 1e-06 28.2 0.0 2.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 PIK59710.1 - 2.9e-13 49.6 0.1 0.00014 22.0 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 PIK59710.1 - 8.1e-10 38.6 0.3 0.00036 20.5 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 PIK59710.1 - 8.5e-07 28.7 0.1 0.0098 15.8 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 PIK59710.1 - 0.0071 16.3 0.0 0.85 9.7 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 PIK59710.1 - 0.0083 16.4 0.0 6.6 7.2 0.0 2.9 2 1 0 2 2 2 2 Galactose oxidase, central domain Man-6-P_recep PF02157.15 PIK59710.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Mannose-6-phosphate receptor BTB PF00651.31 PIK59711.1 - 3.3e-28 98.1 0.1 6.3e-28 97.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 PIK59711.1 - 8.5e-21 74.0 0.6 2.4e-20 72.5 0.2 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.8 PIK59711.1 - 0.0018 18.4 0.0 0.0047 17.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) IL10 PF00726.17 PIK59711.1 - 0.017 14.6 0.2 0.059 12.9 0.0 1.8 2 0 0 2 2 2 0 Interleukin 10 Ca_bind_SSO6904 PF18249.1 PIK59711.1 - 0.11 12.9 0.3 2.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Calcium binding protein SSO6904 Transferrin PF00405.17 PIK59712.1 - 2.4e-127 424.6 2.5 2.3e-91 306.4 0.3 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 PIK59712.1 - 2.2e-12 47.1 0.0 1.1e-10 41.5 0.0 2.8 3 0 0 3 3 3 1 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF247 PF03140.15 PIK59712.1 - 0.092 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function Fibrinogen_C PF00147.18 PIK59713.1 - 2.5e-38 132.1 6.5 2.8e-38 131.9 6.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59714.1 - 1.3e-45 156.0 1.1 1.6e-45 155.6 1.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59715.1 - 3.7e-51 174.0 2.4 4.9e-51 173.6 2.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59716.1 - 3.9e-52 177.2 3.1 4.9e-52 176.9 3.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59717.1 - 3.9e-35 121.7 9.6 4.3e-35 121.5 9.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Apis_Csd PF11671.8 PIK59717.1 - 0.13 12.2 4.5 0.27 11.2 4.5 1.5 1 0 0 1 1 1 0 Complementary sex determiner protein Fibrinogen_C PF00147.18 PIK59718.1 - 0.00045 20.1 0.0 0.00076 19.3 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Herpes_IR6 PF06307.12 PIK59718.1 - 0.074 12.6 0.0 0.086 12.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus IR6 protein Sec7 PF01369.20 PIK59719.1 - 1.2e-63 214.1 0.3 2.7e-63 213.0 0.3 1.6 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 PIK59719.1 - 1e-47 162.0 5.8 2.1e-47 161.0 4.8 2.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 PIK59719.1 - 2.2e-35 121.9 0.6 2.2e-35 121.9 0.6 2.5 2 1 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Luciferase_N PF05295.11 PIK59719.1 - 0.098 12.7 0.0 18 5.4 0.0 2.9 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain DUF1981 PF09324.10 PIK59720.1 - 2.9e-36 123.2 1.6 6.8e-35 118.8 0.1 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) Fibrinogen_C PF00147.18 PIK59721.1 - 2.5e-17 63.4 0.7 3.9e-17 62.8 0.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK59721.1 - 8.3e-05 22.8 3.9 0.00013 22.1 3.9 1.2 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK59721.1 - 0.07 13.2 4.9 0.14 12.2 4.9 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 RVT_1 PF00078.27 PIK59722.1 - 5.8e-18 65.2 0.0 9.9e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK59722.1 - 2.8e-15 56.6 0.0 5.6e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK59722.1 - 2.3e-11 43.4 0.0 5.4e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK59722.1 - 5.9e-06 26.1 1.5 1.2e-05 25.2 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK59722.1 - 0.0003 20.5 0.0 0.00071 19.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_5 PF14787.6 PIK59722.1 - 0.0018 18.0 2.2 0.0045 16.7 2.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 PIK59722.1 - 0.32 10.8 1.9 0.73 9.7 1.9 1.6 1 0 0 1 1 1 0 Zinc knuckle ADAM_spacer1 PF05986.14 PIK59723.1 - 4.3e-28 97.6 0.0 6.6e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 PIK59723.1 - 1.7e-13 51.0 0.2 3.1e-13 50.1 0.2 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 PIK59723.1 - 2.3e-12 47.2 7.5 2.3e-12 47.2 7.5 5.7 3 2 2 5 5 2 1 ADAM cysteine-rich domain TSP_1 PF00090.19 PIK59723.1 - 8.1e-07 29.2 89.6 0.0018 18.5 3.7 8.5 8 3 0 8 8 8 5 Thrombospondin type 1 domain Reprolysin_5 PF13688.6 PIK59723.1 - 1.2e-06 28.9 1.2 1.2e-06 28.9 1.2 2.4 4 0 0 4 4 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK59723.1 - 2.8e-06 27.9 0.1 5.6e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 PIK59723.1 - 7.9e-06 25.9 0.7 2e-05 24.6 0.7 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK59723.1 - 8.3e-06 25.6 0.3 1.4e-05 24.8 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DAGK_cat PF00781.24 PIK59723.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Peptidase_M10 PF00413.24 PIK59723.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.7 PIK59723.1 - 0.16 11.3 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Peptidase_M66 PF10462.9 PIK59723.1 - 0.18 10.7 0.5 0.3 10.0 0.5 1.2 1 0 0 1 1 1 0 Peptidase M66 Cadherin_3 PF16184.5 PIK59724.1 - 3.6e-104 342.5 19.4 1.1e-22 80.2 0.1 7.4 7 0 0 7 7 7 7 Cadherin-like Lectin_C PF00059.21 PIK59724.1 - 5.1e-19 69.0 1.1 9.2e-19 68.2 0.7 1.7 2 0 0 2 2 2 1 Lectin C-type domain Big_9 PF17963.1 PIK59724.1 - 5.2e-10 39.9 11.0 0.0087 16.8 0.1 7.2 7 0 0 7 7 7 3 Bacterial Ig domain Cadherin_4 PF17803.1 PIK59724.1 - 1e-05 26.0 2.0 2.3 8.9 0.2 5.2 5 0 0 5 5 5 2 Bacterial cadherin-like domain Calx-beta PF03160.14 PIK59724.1 - 0.00026 21.1 0.0 0.0012 19.0 0.0 2.2 1 0 0 1 1 1 1 Calx-beta domain CBM_21 PF03370.13 PIK59724.1 - 0.14 12.3 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Carbohydrate/starch-binding module (family 21) Cadherin_3 PF16184.5 PIK59725.1 - 1.5e-69 231.0 4.7 7.2e-23 80.7 0.0 5.2 5 0 0 5 5 5 5 Cadherin-like Big_9 PF17963.1 PIK59725.1 - 1.9e-05 25.3 0.5 0.04 14.7 0.0 4.3 6 1 0 6 6 6 1 Bacterial Ig domain Cadherin_4 PF17803.1 PIK59725.1 - 7.2e-05 23.3 0.6 0.037 14.7 0.0 3.8 4 0 0 4 4 4 1 Bacterial cadherin-like domain Cuticle_1 PF08140.11 PIK59726.1 - 0.16 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Crustacean cuticle protein repeat MFS_1 PF07690.16 PIK59727.1 - 1.5e-38 132.6 17.6 1.5e-38 132.6 17.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK59727.1 - 1.7e-05 23.9 15.2 0.00061 18.8 15.2 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter NAGLU PF05089.12 PIK59728.1 - 7.6e-116 386.7 5.0 5.2e-86 288.6 1.2 2.7 2 1 1 3 3 3 2 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 PIK59728.1 - 9.9e-82 274.4 6.3 1.3e-81 274.1 6.3 1.1 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 PIK59728.1 - 5.3e-18 64.6 0.0 1.2e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain SAM_1 PF00536.30 PIK59729.1 - 0.14 12.6 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Nop14 PF04147.12 PIK59729.1 - 0.46 8.6 5.0 0.62 8.2 5.0 1.1 1 0 0 1 1 1 0 Nop14-like family Pkinase PF00069.25 PIK59730.1 - 6.7e-46 156.8 0.0 7.1e-43 146.9 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59730.1 - 3.2e-21 75.8 0.1 4.9e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1908 PF08926.11 PIK59730.1 - 3.5e-17 62.4 1.0 3.6e-14 52.5 0.2 3.2 3 2 1 4 4 4 2 Domain of unknown function (DUF1908) Kinase-like PF14531.6 PIK59730.1 - 3.8e-05 23.2 0.1 0.00058 19.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 PIK59730.1 - 5.7e-05 23.2 0.0 0.025 14.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 PIK59730.1 - 0.0013 17.6 0.0 0.0026 16.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK59730.1 - 0.029 13.3 0.0 0.053 12.5 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 PIK59730.1 - 0.035 13.7 0.0 3.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PDZ_6 PF17820.1 PIK59731.1 - 1.8e-10 40.5 0.3 3.5e-10 39.6 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 PIK59731.1 - 3.1e-08 33.8 0.0 5.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK59731.1 - 4.6e-06 26.9 0.0 8.6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PBP_sp32 PF07222.12 PIK59732.1 - 0.28 10.6 4.7 0.43 10.0 4.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Tho2 PF11262.8 PIK59732.1 - 2.3 7.3 8.5 3.4 6.8 8.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Presenilin PF01080.17 PIK59732.1 - 2.9 6.6 3.8 4.6 5.9 3.8 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 PIK59732.1 - 4.3 5.5 8.9 6.3 5.0 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S49_N PF08496.10 PIK59732.1 - 8.3 6.5 11.4 14 5.7 11.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HhH-GPD PF00730.25 PIK59733.1 - 1.5e-15 57.6 0.0 3.1e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 PIK59733.1 - 3.3e-07 30.3 0.0 6.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 PIK59733.1 - 5.4e-05 22.8 0.0 0.00018 21.2 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif RseC_MucC PF04246.12 PIK59733.1 - 0.039 13.9 0.7 0.07 13.1 0.7 1.4 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF1924 PF09086.11 PIK59733.1 - 0.52 10.7 4.2 5.2 7.5 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) gag-asp_proteas PF13975.6 PIK59734.1 - 9.5e-07 29.3 0.0 1.6e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK59734.1 - 0.017 15.8 0.0 0.043 14.5 0.0 1.7 2 0 0 2 2 2 0 Aspartyl protease TPR_1 PF00515.28 PIK59735.1 - 0.00052 19.7 0.2 0.014 15.2 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat CwsA PF10814.8 PIK59735.1 - 0.03 14.5 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA FapA PF03961.13 PIK59735.1 - 0.043 12.4 3.3 0.043 12.4 3.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPR_2 PF07719.17 PIK59735.1 - 0.051 13.7 0.1 8.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Baculo_F PF12259.8 PIK59735.1 - 0.087 11.3 2.7 0.1 11.1 2.7 1.1 1 0 0 1 1 1 0 Baculovirus F protein DUF1664 PF07889.12 PIK59735.1 - 0.1 12.6 2.5 0.22 11.6 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TPR_7 PF13176.6 PIK59735.1 - 0.13 12.3 0.0 4.9 7.4 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ISG65-75 PF11727.8 PIK59735.1 - 0.64 9.2 9.3 0.12 11.5 6.0 1.4 2 0 0 2 2 2 0 Invariant surface glycoprotein Fib_alpha PF08702.10 PIK59735.1 - 0.69 10.1 6.8 0.11 12.7 2.9 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FliD_N PF02465.18 PIK59735.1 - 0.76 10.5 5.9 1.6 9.5 5.9 1.7 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF2203 PF09969.9 PIK59735.1 - 2.8 8.7 8.3 0.62 10.8 2.9 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) NAC PF01849.18 PIK59737.1 - 1.6e-21 76.0 0.3 1.1e-20 73.3 0.0 2.2 2 0 0 2 2 2 1 NAC domain DUF768 PF05589.11 PIK59737.1 - 0.02 14.9 0.1 0.042 13.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF768) NAC PF01849.18 PIK59738.1 - 4.8e-25 87.3 0.0 1.2e-24 86.1 0.0 1.7 1 0 0 1 1 1 1 NAC domain DNA_repr_REX1B PF14966.6 PIK59739.1 - 1.3e-19 70.6 0.6 1.5e-19 70.4 0.6 1.0 1 0 0 1 1 1 1 DNA repair REX1-B DUF3480 PF11979.8 PIK59740.1 - 2.8e-143 477.1 0.0 4.4e-143 476.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) FYVE PF01363.21 PIK59740.1 - 6.5e-19 67.8 13.4 1.4e-18 66.7 13.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger Fanconi_A_N PF15865.5 PIK59740.1 - 0.056 12.8 0.2 0.14 11.5 0.1 1.7 2 0 0 2 2 2 0 Fanconi anaemia group A protein N terminus zf_C2HC_14 PF18574.1 PIK59740.1 - 0.52 10.2 13.9 0.23 11.3 4.6 2.5 2 0 0 2 2 2 0 C2HC Zing finger domain Actin PF00022.19 PIK59741.1 - 2.2e-60 204.4 0.4 6.6e-41 140.3 0.1 4.6 3 1 0 3 3 3 3 Actin Rapsyn_N PF10579.9 PIK59741.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Kinesin PF00225.23 PIK59742.1 - 8.4e-28 97.3 0.1 2e-27 96.0 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain DUF4472 PF14739.6 PIK59742.1 - 9.3e-15 55.3 7.5 9.3e-15 55.3 7.5 5.9 5 2 0 5 5 5 2 Domain of unknown function (DUF4472) DUF2935 PF11155.8 PIK59742.1 - 0.03 14.6 9.2 3 8.2 0.4 4.7 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) Maelstrom PF13017.6 PIK59742.1 - 0.071 12.8 0.2 0.62 9.7 0.1 2.5 2 1 0 2 2 2 0 piRNA pathway germ-plasm component PTEN_C2 PF10409.9 PIK59743.1 - 1.7e-21 76.4 0.1 2.8e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.31 PIK59743.1 - 8.7e-06 25.8 0.0 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Cwf_Cwc_15 PF04889.12 PIK59743.1 - 0.042 13.6 3.1 0.088 12.5 3.1 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GCIP PF13324.6 PIK59743.1 - 9.4 5.8 6.1 18 4.8 6.1 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Pkinase PF00069.25 PIK59744.1 - 3.9e-41 141.2 0.0 5.6e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59744.1 - 3.1e-30 105.3 0.0 4.1e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK59744.1 - 7.3e-06 25.2 0.1 9.7e-06 24.8 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 PIK59744.1 - 0.0022 17.4 0.0 0.0047 16.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 PIK59744.1 - 0.0039 16.3 0.1 0.0063 15.6 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase PF00069.25 PIK59745.1 - 1.4e-70 237.7 0.1 1.6e-70 237.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59745.1 - 4.1e-38 131.1 0.0 5.1e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59745.1 - 1.4e-07 31.1 0.0 5.3e-06 25.9 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK59745.1 - 0.00033 19.6 0.0 0.00053 18.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 PIK59745.1 - 0.014 14.4 0.3 0.023 13.7 0.3 1.4 1 1 0 1 1 1 0 Haspin like kinase domain CH PF00307.31 PIK59746.1 - 2.4e-10 40.5 0.1 3.6e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain dCache_1 PF02743.18 PIK59747.1 - 2.6e-08 33.9 0.1 0.00085 19.2 0.1 2.2 2 0 0 2 2 2 2 Cache domain VWA_N PF08399.11 PIK59748.1 - 1.9e-10 41.3 0.1 6.1e-10 39.6 0.1 2.0 1 1 0 1 1 1 1 VWA N-terminal dCache_1 PF02743.18 PIK59748.1 - 3.7e-10 40.0 0.2 7.1e-09 35.8 0.0 2.5 3 1 0 3 3 3 1 Cache domain VWA_3 PF13768.6 PIK59748.1 - 0.00035 20.5 0.0 0.0014 18.6 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 PIK59748.1 - 0.0011 19.3 0.4 0.0065 16.7 0.1 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK59748.1 - 0.0038 17.9 0.0 0.12 13.1 0.0 2.5 1 1 1 2 2 2 1 von Willebrand factor type A domain fn3 PF00041.21 PIK59749.1 - 8.5e-11 42.1 1.6 0.0058 17.0 0.1 3.8 3 0 0 3 3 3 3 Fibronectin type III domain MBF2 PF15868.5 PIK59749.1 - 0.1 13.2 0.4 0.52 10.9 0.1 2.2 2 0 0 2 2 2 0 Transcription activator MBF2 SlyX PF04102.12 PIK59750.1 - 0.098 13.3 0.1 0.18 12.4 0.1 1.4 1 0 0 1 1 1 0 SlyX EloA-BP1 PF15870.5 PIK59751.1 - 7.4e-39 133.7 12.1 8e-29 101.0 0.1 3.3 2 1 1 3 3 3 2 ElonginA binding-protein 1 RNase_T PF00929.24 PIK59751.1 - 3.5e-08 34.2 0.2 2.4e-07 31.5 0.1 2.3 2 1 0 2 2 2 1 Exonuclease Ecotin PF03974.13 PIK59751.1 - 0.1 12.6 0.3 0.98 9.4 0.0 2.7 3 1 0 3 3 3 0 Ecotin Tctex-1 PF03645.13 PIK59752.1 - 2e-23 82.6 0.1 2.7e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 Tctex-1 family DOCK-C2 PF14429.6 PIK59753.1 - 1.7e-15 57.3 0.0 1.9e-06 27.8 0.0 2.5 1 1 1 2 2 2 2 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 PIK59753.1 - 2.9e-14 53.5 2.6 9.5e-14 51.8 2.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) DOCK_N PF16172.5 PIK59753.1 - 0.00011 21.3 0.0 0.00017 20.6 0.0 1.2 1 0 0 1 1 1 1 DOCK N-terminus DUF1922 PF09082.10 PIK59754.1 - 0.014 15.7 1.3 7.4 6.9 0.1 3.9 4 2 0 4 4 4 0 Domain of unknown function (DUF1922) Pico_P2A PF00947.19 PIK59754.1 - 0.032 14.2 0.4 8.3 6.4 0.0 2.7 2 1 1 3 3 3 0 Picornavirus core protein 2A DHR-2 PF06920.13 PIK59756.1 - 4.3e-144 481.1 4.3 4.9e-141 471.0 4.3 3.4 1 1 0 1 1 1 1 Dock homology region 2 ADK PF00406.22 PIK59757.1 - 4.3e-50 169.7 0.0 5.1e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 PIK59757.1 - 2.4e-22 79.8 0.0 5.2e-22 78.7 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 PIK59757.1 - 4.1e-16 58.6 0.0 6.6e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 PIK59757.1 - 0.00011 22.8 0.0 0.0003 21.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 PIK59757.1 - 0.0006 20.0 0.1 0.0022 18.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 PIK59757.1 - 0.013 15.2 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase PNK3P PF08645.11 PIK59758.1 - 6.1e-54 182.1 0.0 1.1e-53 181.3 0.0 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 PIK59758.1 - 3.9e-17 62.8 0.0 6.7e-09 36.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain Zeta_toxin PF06414.12 PIK59758.1 - 5.1e-08 32.4 0.0 0.0028 17.0 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin KTI12 PF08433.10 PIK59758.1 - 0.044 13.2 0.3 3 7.2 0.3 2.1 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 PIK59758.1 - 0.054 13.9 0.0 0.088 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 PIK59758.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain FAD_binding_4 PF01565.23 PIK59759.1 - 3.7e-15 55.9 0.0 5.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_4 PF01565.23 PIK59760.1 - 4.6e-06 26.4 0.0 0.094 12.5 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain SlyX PF04102.12 PIK59761.1 - 3e-06 27.8 18.7 0.14 12.8 0.1 6.4 5 2 2 7 7 6 2 SlyX BLOC1_2 PF10046.9 PIK59761.1 - 2.1e-05 24.8 17.6 0.0092 16.3 0.1 5.7 4 2 1 6 6 6 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Leu_zip PF15294.6 PIK59761.1 - 0.00019 21.1 6.4 0.00019 21.1 6.4 1.9 2 1 1 3 3 1 1 Leucine zipper DUF4407 PF14362.6 PIK59761.1 - 0.00021 20.8 3.7 0.00048 19.6 0.4 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 PIK59761.1 - 0.00026 21.2 21.6 0.00052 20.2 6.8 4.3 2 2 1 4 4 4 1 Fibrinogen alpha/beta chain family TSC22 PF01166.18 PIK59761.1 - 0.00042 20.6 0.3 11 6.4 0.3 4.7 4 0 0 4 4 4 0 TSC-22/dip/bun family DUF3584 PF12128.8 PIK59761.1 - 0.00051 17.7 2.6 0.00051 17.7 2.6 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3584) UPF0242 PF06785.11 PIK59761.1 - 0.00085 19.5 1.6 0.018 15.1 0.7 2.4 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 PIK59761.1 - 0.0025 16.8 4.3 0.0025 16.8 4.3 2.6 2 1 1 3 3 3 1 Spc7 kinetochore protein DUF948 PF06103.11 PIK59761.1 - 0.0043 17.3 21.2 1.6 9.1 0.2 5.0 3 1 1 4 4 4 2 Bacterial protein of unknown function (DUF948) DUF724 PF05266.14 PIK59761.1 - 0.0045 16.8 1.5 0.0045 16.8 1.5 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF724) SKA2 PF16740.5 PIK59761.1 - 0.0084 15.9 13.0 0.18 11.6 2.5 4.2 2 1 2 4 4 4 1 Spindle and kinetochore-associated protein 2 Troponin PF00992.20 PIK59761.1 - 0.0088 16.4 0.1 1.1 9.6 0.2 2.7 3 0 0 3 3 2 1 Troponin Prefoldin PF02996.17 PIK59761.1 - 0.0089 15.9 11.7 0.77 9.7 0.6 4.5 4 1 1 5 5 4 2 Prefoldin subunit Spectrin PF00435.21 PIK59761.1 - 0.01 16.3 11.9 0.12 12.9 1.3 4.8 2 2 2 4 4 4 0 Spectrin repeat ATG16 PF08614.11 PIK59761.1 - 0.011 16.0 14.0 0.37 11.0 2.7 3.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 PIK59761.1 - 0.013 15.5 13.6 0.26 11.3 1.2 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DivIC PF04977.15 PIK59761.1 - 0.019 14.7 6.7 6 6.7 0.1 4.2 4 0 0 4 4 3 0 Septum formation initiator ZapB PF06005.12 PIK59761.1 - 0.019 15.4 11.0 5.9 7.4 3.4 4.6 3 2 1 4 4 3 0 Cell division protein ZapB PLAC9 PF15205.6 PIK59761.1 - 0.029 14.8 0.0 0.53 10.7 0.0 3.0 3 0 0 3 3 1 0 Placenta-specific protein 9 DUF3138 PF11336.8 PIK59761.1 - 0.031 12.9 3.9 0.047 12.3 3.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Atg14 PF10186.9 PIK59761.1 - 0.035 13.2 4.1 0.66 9.0 3.4 2.3 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4201 PF13870.6 PIK59761.1 - 0.037 13.8 3.3 0.22 11.2 0.1 3.1 3 1 1 4 4 3 0 Domain of unknown function (DUF4201) Csm1_N PF18504.1 PIK59761.1 - 0.041 14.2 16.7 2.8 8.3 0.3 5.6 6 0 0 6 6 5 0 Csm1 N-terminal domain zf-C4H2 PF10146.9 PIK59761.1 - 0.041 14.2 5.4 0.03 14.7 2.9 2.1 2 1 0 2 2 1 0 Zinc finger-containing protein FlaC_arch PF05377.11 PIK59761.1 - 0.043 14.2 15.9 2.6 8.5 0.6 5.7 5 1 2 7 7 5 0 Flagella accessory protein C (FlaC) HBM PF16591.5 PIK59761.1 - 0.051 13.0 8.7 0.2 11.1 2.3 2.9 2 1 1 3 3 3 0 Helical bimodular sensor domain Fez1 PF06818.15 PIK59761.1 - 0.057 13.9 6.9 0.036 14.5 3.1 2.4 1 1 2 3 3 2 0 Fez1 Apolipoprotein PF01442.18 PIK59761.1 - 0.063 13.2 6.1 0.73 9.7 6.1 2.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HAUS-augmin3 PF14932.6 PIK59761.1 - 0.063 12.8 5.3 0.054 13.1 1.0 2.4 1 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 DUF4618 PF15397.6 PIK59761.1 - 0.1 12.0 10.6 4.2 6.7 0.3 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4618) Vps53_N PF04100.12 PIK59761.1 - 0.11 11.5 14.1 0.12 11.3 4.0 2.7 3 0 0 3 3 3 0 Vps53-like, N-terminal Seryl_tRNA_N PF02403.22 PIK59761.1 - 0.11 12.7 10.4 0.037 14.2 2.4 3.5 4 1 1 5 5 3 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 PIK59761.1 - 0.12 12.9 16.6 0.25 11.8 0.5 3.9 2 2 1 3 3 3 0 Protein of unknown function DUF16 LXG PF04740.12 PIK59761.1 - 0.12 12.1 14.4 1.1 9.0 2.3 4.0 3 1 1 4 4 4 0 LXG domain of WXG superfamily Snapin_Pallidin PF14712.6 PIK59761.1 - 0.12 12.8 10.4 6.4 7.3 0.3 4.4 2 1 2 4 4 4 0 Snapin/Pallidin Prefoldin_2 PF01920.20 PIK59761.1 - 0.14 12.2 10.6 21 5.1 2.6 4.7 3 1 1 4 4 4 0 Prefoldin subunit COG5 PF10392.9 PIK59761.1 - 0.18 12.0 15.7 3.1 8.0 1.2 4.0 3 1 1 4 4 4 0 Golgi transport complex subunit 5 Hormone_1 PF00103.20 PIK59761.1 - 0.22 11.3 1.5 1.2 8.9 0.1 2.5 1 1 2 3 3 2 0 Somatotropin hormone family GAS PF13851.6 PIK59761.1 - 0.22 10.8 7.6 8 5.8 4.0 3.4 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.9 PIK59761.1 - 0.23 11.6 11.1 0.034 14.4 3.2 3.0 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 IFT57 PF10498.9 PIK59761.1 - 0.26 10.2 6.7 0.3 10.0 5.0 1.8 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 FliD_N PF02465.18 PIK59761.1 - 0.27 11.9 17.7 18 6.1 8.3 4.1 2 1 1 3 3 2 0 Flagellar hook-associated protein 2 N-terminus LPP PF04728.13 PIK59761.1 - 0.3 11.5 19.2 5.7 7.4 0.1 5.9 4 1 0 4 4 4 0 Lipoprotein leucine-zipper ATP-synt_D PF01813.17 PIK59761.1 - 0.32 10.8 2.5 2.4 7.9 2.1 2.2 1 1 1 2 2 2 0 ATP synthase subunit D Fmp27_WPPW PF10359.9 PIK59761.1 - 0.35 9.7 7.6 0.36 9.6 1.1 2.4 2 1 1 3 3 2 0 RNA pol II promoter Fmp27 protein domain F_actin_bind PF08919.10 PIK59761.1 - 0.36 10.9 8.8 11 6.2 0.0 4.3 3 1 1 5 5 4 0 F-actin binding KxDL PF10241.9 PIK59761.1 - 0.37 11.1 10.7 2.4 8.5 1.3 4.8 4 1 1 5 5 5 0 Uncharacterized conserved protein Trimer_CC PF08954.11 PIK59761.1 - 0.38 10.4 6.2 65 3.2 0.1 4.8 5 0 0 5 5 4 0 Trimerisation motif Allexi_40kDa PF05549.11 PIK59761.1 - 0.4 10.1 15.7 0.62 9.5 8.4 3.4 2 1 1 3 3 3 0 Allexivirus 40kDa protein MbeD_MobD PF04899.12 PIK59761.1 - 0.41 10.8 3.6 22 5.3 0.8 4.0 3 1 1 4 4 3 0 MbeD/MobD like DUF4686 PF15742.5 PIK59761.1 - 0.46 9.6 11.7 0.031 13.4 5.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4686) DUF1515 PF07439.11 PIK59761.1 - 0.58 10.2 5.7 1.1 9.3 0.7 3.3 3 1 1 4 4 3 0 Protein of unknown function (DUF1515) ParB PF08775.10 PIK59761.1 - 0.63 10.5 8.8 5.6 7.5 0.2 3.0 2 1 1 3 3 2 0 ParB family Golgin_A5 PF09787.9 PIK59761.1 - 0.64 9.4 12.4 0.028 13.9 6.0 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 T7SS_ESX_EspC PF10824.8 PIK59761.1 - 0.7 10.4 5.1 13 6.4 0.6 2.8 3 0 0 3 3 2 0 Excreted virulence factor EspC, type VII ESX diderm TMF_DNA_bd PF12329.8 PIK59761.1 - 0.81 9.7 17.5 2.9 7.9 0.9 4.9 4 1 2 6 6 4 0 TATA element modulatory factor 1 DNA binding DUF3829 PF12889.7 PIK59761.1 - 0.85 9.0 5.6 1.9 7.9 4.4 2.1 2 1 1 3 3 2 0 Protein of unknown function (DUF3829) Tropomyosin PF00261.20 PIK59761.1 - 1 8.7 8.6 1.6 8.1 0.3 3.9 2 1 2 4 4 4 0 Tropomyosin FlxA PF14282.6 PIK59761.1 - 1.1 9.3 17.7 1.4 8.9 5.6 4.0 2 1 2 4 4 3 0 FlxA-like protein DUF4795 PF16043.5 PIK59761.1 - 1.3 8.6 13.8 7.7 6.1 2.5 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4795) DHR-2 PF06920.13 PIK59761.1 - 1.4 7.5 4.7 0.47 9.0 0.1 2.4 2 1 1 3 3 3 0 Dock homology region 2 TMPIT PF07851.13 PIK59761.1 - 1.4 8.1 4.1 2.7 7.2 3.7 1.7 1 1 0 1 1 1 0 TMPIT-like protein KLRAQ PF10205.9 PIK59761.1 - 1.5 9.1 8.5 1.9 8.8 0.3 3.9 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein Sas10_Utp3 PF04000.15 PIK59761.1 - 1.5 9.5 16.6 8.2 7.1 0.6 5.1 5 0 0 5 5 4 0 Sas10/Utp3/C1D family DUF2205 PF10224.9 PIK59761.1 - 1.6 8.8 5.6 22 5.2 0.0 3.9 2 1 2 4 4 3 0 Short coiled-coil protein TolA_bind_tri PF16331.5 PIK59761.1 - 1.9 8.6 14.3 1.2 9.2 0.7 4.6 2 1 1 4 4 3 0 TolA binding protein trimerisation TPR_MLP1_2 PF07926.12 PIK59761.1 - 1.9 8.5 13.6 0.31 11.1 4.2 3.5 4 1 1 5 5 4 0 TPR/MLP1/MLP2-like protein MAP65_ASE1 PF03999.12 PIK59761.1 - 2 7.0 10.7 0.14 10.8 5.5 1.5 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) ADIP PF11559.8 PIK59761.1 - 2.1 8.4 13.5 0.39 10.8 1.4 3.5 2 1 2 4 4 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 PIK59761.1 - 2.1 9.0 12.0 2.1 9.0 3.2 4.1 4 1 0 4 4 2 0 Initiation control protein YabA Phage_GPO PF05929.11 PIK59761.1 - 2.3 7.8 8.5 0.74 9.4 4.7 2.1 2 1 1 3 3 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF5082 PF16888.5 PIK59761.1 - 2.4 8.5 12.8 6.8 7.0 1.0 4.1 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) CdvA PF18822.1 PIK59761.1 - 3.6 7.4 9.3 9.7 6.0 1.7 4.5 3 2 1 4 4 4 0 CdvA-like coiled-coil domain Sec34 PF04136.15 PIK59761.1 - 3.7 7.4 11.8 0.92 9.4 1.0 3.6 2 1 2 4 4 4 0 Sec34-like family AAA_13 PF13166.6 PIK59761.1 - 3.9 6.0 15.2 1.1 7.8 6.3 2.3 2 1 1 3 3 3 0 AAA domain DUF4665 PF15679.5 PIK59761.1 - 4.4 8.0 7.4 21 5.8 1.6 3.5 1 1 3 4 4 3 0 Domain of unknown function (DUF4665) XhlA PF10779.9 PIK59761.1 - 4.8 7.5 15.6 30 4.9 0.1 5.2 4 1 0 4 4 4 0 Haemolysin XhlA EzrA PF06160.12 PIK59761.1 - 4.9 5.2 11.9 0.29 9.3 3.4 2.7 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 PIK59761.1 - 5.2 7.6 31.5 0.87 10.1 3.4 5.7 3 1 3 6 6 5 0 Nucleopolyhedrovirus P10 protein CENP-H PF05837.12 PIK59761.1 - 6.4 7.2 15.2 1.7 9.1 5.0 3.4 4 1 0 4 4 2 0 Centromere protein H (CENP-H) RmuC PF02646.16 PIK59761.1 - 7.2 5.6 12.7 0.47 9.5 1.6 2.9 2 1 1 3 3 2 0 RmuC family V_ATPase_I PF01496.19 PIK59761.1 - 7.4 4.3 6.3 21 2.9 3.0 2.8 3 1 1 4 4 4 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 PIK59761.1 - 7.7 6.7 13.1 6.5 6.9 1.2 3.6 2 1 1 3 3 3 0 Tropomyosin like Pkinase PF00069.25 PIK59762.1 - 1.6e-71 240.8 0.0 2.1e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59762.1 - 1.9e-39 135.5 0.0 2.6e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59762.1 - 2.9e-11 43.2 0.0 4.5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK59762.1 - 1.7e-05 24.3 0.5 0.00072 19.0 0.3 2.3 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK59762.1 - 0.00029 20.5 0.1 0.00049 19.7 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pet100 PF09803.9 PIK59763.1 - 3.5e-19 69.1 6.0 3.8e-19 69.0 5.4 1.3 1 1 0 1 1 1 1 Pet100 EF-hand_4 PF12763.7 PIK59764.1 - 1.2e-35 121.6 0.0 1.1e-17 63.9 0.1 3.6 2 1 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 PIK59764.1 - 1.6e-11 42.9 0.1 0.066 12.8 0.0 5.1 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 PIK59764.1 - 8.7e-09 35.7 0.6 0.0054 17.1 0.0 4.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK59764.1 - 1.1e-06 28.1 0.1 0.17 11.9 0.0 5.0 5 0 0 5 5 5 1 EF-hand domain EF-hand_8 PF13833.6 PIK59764.1 - 0.0024 17.7 1.6 0.091 12.6 0.6 2.9 1 1 1 2 2 2 2 EF-hand domain pair HrpB7 PF09486.10 PIK59764.1 - 0.0042 17.5 26.7 0.26 11.6 4.5 3.2 1 1 2 3 3 3 2 Bacterial type III secretion protein (HrpB7) EF-hand_5 PF13202.6 PIK59764.1 - 0.0069 15.8 4.6 0.24 10.9 0.2 3.3 3 0 0 3 3 3 1 EF hand Spc7 PF08317.11 PIK59764.1 - 0.015 14.2 44.4 0.16 10.8 22.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein HMMR_N PF15905.5 PIK59764.1 - 0.096 12.1 42.2 0.7 9.3 21.4 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ATG16 PF08614.11 PIK59764.1 - 0.13 12.5 42.1 0.067 13.4 11.4 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 PIK59764.1 - 0.24 8.8 33.9 0.34 8.4 33.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4795 PF16043.5 PIK59764.1 - 0.42 10.2 24.9 0.85 9.2 24.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) CENP-F_leu_zip PF10473.9 PIK59764.1 - 0.46 10.5 45.3 0.32 11.0 24.0 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MscS_porin PF12795.7 PIK59764.1 - 0.47 9.9 49.4 0.7 9.4 7.6 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DegS PF05384.11 PIK59764.1 - 0.67 9.4 29.5 0.084 12.4 12.7 2.3 1 1 1 2 2 2 0 Sensor protein DegS TPR_MLP1_2 PF07926.12 PIK59764.1 - 1.1 9.3 41.8 0.21 11.6 28.8 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 PIK59764.1 - 1.1 9.4 32.2 1.9 8.7 8.3 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Laminin_I PF06008.14 PIK59764.1 - 1.7 8.3 37.9 0.73 9.5 21.3 2.2 1 1 1 2 2 2 0 Laminin Domain I IFT57 PF10498.9 PIK59764.1 - 1.9 7.4 33.2 17 4.3 31.6 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 BRE1 PF08647.11 PIK59764.1 - 2.4 8.3 43.5 1.2 9.3 15.0 3.0 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase ERM PF00769.19 PIK59764.1 - 2.5 7.8 41.6 3.7 7.3 40.6 1.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Prominin PF05478.11 PIK59764.1 - 3 5.7 23.4 4.1 5.3 23.4 1.1 1 0 0 1 1 1 0 Prominin AAA_13 PF13166.6 PIK59764.1 - 3.4 6.2 31.1 57 2.1 31.4 2.0 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.11 PIK59764.1 - 3.8 7.8 20.0 1.4 9.2 0.5 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SPARC_Ca_bdg PF10591.9 PIK59764.1 - 4 7.8 9.1 7.5 6.9 0.0 3.1 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FlaC_arch PF05377.11 PIK59764.1 - 5.5 7.5 27.4 0.061 13.7 1.2 5.2 2 2 3 5 5 5 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 PIK59764.1 - 8 5.4 36.9 61 2.5 37.1 2.1 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HECT PF00632.25 PIK59765.1 - 1.4e-82 277.7 0.0 2.6e-82 276.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 PIK59765.1 - 0.33 10.9 1.4 0.97 9.4 1.4 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Peptidase_M16 PF00675.20 PIK59766.1 - 5.8e-37 127.0 0.0 1e-36 126.2 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 PIK59766.1 - 9.3e-09 35.6 0.1 2.2e-08 34.3 0.1 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain IZUMO PF15005.6 PIK59766.1 - 0.05 14.1 0.0 0.099 13.2 0.0 1.4 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Mhr1 PF12829.7 PIK59766.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Peptidase_M16_M PF16187.5 PIK59767.1 - 8.1e-17 61.4 0.1 9.1e-17 61.2 0.1 1.0 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_M PF16187.5 PIK59768.1 - 5.2e-30 104.7 0.4 7.7e-30 104.1 0.4 1.2 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 PIK59768.1 - 2.5e-06 27.6 0.0 6.2e-05 23.1 0.0 2.3 2 1 0 2 2 2 1 Peptidase M16 inactive domain Rav1p_C PF12234.8 PIK59768.1 - 0.0006 18.3 0.1 0.00073 18.1 0.1 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal DUF4094 PF13334.6 PIK59770.1 - 1e-05 25.9 15.2 0.0098 16.3 0.0 3.2 2 1 1 4 4 4 2 Domain of unknown function (DUF4094) Vinculin PF01044.19 PIK59770.1 - 0.0015 16.9 7.8 0.002 16.5 7.8 1.1 1 0 0 1 1 1 1 Vinculin family DUF5320 PF17253.2 PIK59770.1 - 0.0063 17.5 12.5 0.11 13.5 0.0 3.5 2 1 1 3 3 3 1 Family of unknown function (DUF5320) UPF0231 PF06062.11 PIK59770.1 - 0.0067 16.7 2.4 0.0067 16.7 2.4 2.2 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0231) FapA PF03961.13 PIK59770.1 - 0.0097 14.6 18.2 0.26 9.8 0.8 2.1 2 0 0 2 2 2 2 Flagellar Assembly Protein A TetR_C_24 PF17932.1 PIK59770.1 - 0.029 14.6 0.2 0.084 13.1 0.1 1.8 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain CENP-Q PF13094.6 PIK59770.1 - 0.033 14.4 14.2 0.26 11.5 13.9 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit V-ATPase_G_2 PF16999.5 PIK59770.1 - 0.077 13.4 20.5 0.052 14.0 7.9 3.0 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit TSC22 PF01166.18 PIK59770.1 - 0.16 12.3 12.0 2.1 8.7 2.2 3.9 4 1 0 4 4 4 0 TSC-22/dip/bun family DUF4140 PF13600.6 PIK59770.1 - 0.36 11.3 13.4 0.46 11.0 0.1 3.5 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) RapA_C PF12137.8 PIK59770.1 - 0.47 9.4 13.9 0.071 12.1 8.0 2.1 2 0 0 2 2 2 0 RNA polymerase recycling family C-terminal Csm1_N PF18504.1 PIK59770.1 - 0.48 10.8 27.4 0.17 12.3 2.3 3.8 3 1 1 4 4 4 0 Csm1 N-terminal domain End3 PF12761.7 PIK59770.1 - 0.58 10.3 24.0 0.68 10.1 3.3 2.5 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF4085 PF13315.6 PIK59770.1 - 0.59 9.7 12.5 0.034 13.8 7.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4085) DUF3552 PF12072.8 PIK59770.1 - 0.64 9.4 22.9 2.1 7.7 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF883 PF05957.13 PIK59770.1 - 0.68 10.6 18.0 0.17 12.5 1.7 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Mst1_SARAH PF11629.8 PIK59770.1 - 0.9 9.7 8.2 0.3 11.2 1.7 2.6 3 0 0 3 3 2 0 C terminal SARAH domain of Mst1 DUF4618 PF15397.6 PIK59770.1 - 1 8.7 20.5 0.92 8.9 13.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) ApoO PF09769.9 PIK59770.1 - 1.1 9.2 6.2 6.3 6.8 0.0 3.0 2 1 0 2 2 2 0 Apolipoprotein O Baculo_PEP_C PF04513.12 PIK59770.1 - 1.2 9.1 7.2 1.6 8.8 2.4 2.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus JIP_LZII PF16471.5 PIK59770.1 - 4.5 7.5 20.3 4.3 7.6 5.3 3.6 3 1 1 4 4 3 0 JNK-interacting protein leucine zipper II Cnn_1N PF07989.11 PIK59770.1 - 4.7 7.5 26.4 1.2 9.3 1.4 3.6 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF4407 PF14362.6 PIK59770.1 - 5.3 6.3 21.1 6.9 5.9 4.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) MobC PF05713.11 PIK59770.1 - 6.3 7.4 6.2 1.5 9.3 0.3 2.7 3 0 0 3 3 3 0 Bacterial mobilisation protein (MobC) TPR_MLP1_2 PF07926.12 PIK59770.1 - 6.7 6.8 32.7 4 7.5 3.6 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Fzo_mitofusin PF04799.13 PIK59770.1 - 8.3 5.9 15.3 1.3 8.5 7.2 2.7 2 1 0 2 2 2 0 fzo-like conserved region CoA_trans PF01144.23 PIK59771.1 - 5.8e-103 342.9 0.2 1.5e-54 184.7 0.0 2.5 2 1 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 PIK59771.1 - 0.0009 19.2 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Ribonuc_red_sm PF00268.21 PIK59772.1 - 1.7e-113 378.7 0.2 2.1e-113 378.4 0.2 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain NMT PF01233.19 PIK59772.1 - 0.0084 16.0 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain VCBS PF13517.6 PIK59774.1 - 4.3e-07 30.4 1.1 0.028 15.0 0.5 2.9 2 1 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK59774.1 - 0.0029 17.7 1.1 0.079 13.1 0.0 2.4 2 0 0 2 2 2 1 FG-GAP repeat Dynein_light PF01221.18 PIK59775.1 - 1.4e-35 121.5 0.1 1.6e-35 121.3 0.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 KLRAQ PF10205.9 PIK59775.1 - 0.067 13.4 1.0 0.084 13.1 1.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Methyltransf_11 PF08241.12 PIK59776.1 - 4e-16 59.5 0.0 6.9e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK59776.1 - 1.8e-15 57.4 0.0 3.3e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK59776.1 - 5.9e-10 39.1 0.0 9e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK59776.1 - 5e-08 33.6 0.0 8.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK59776.1 - 2.5e-05 24.2 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK59776.1 - 0.00013 21.4 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 PIK59776.1 - 0.0021 17.6 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK59776.1 - 0.0061 16.0 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.20 PIK59776.1 - 0.014 14.7 0.0 0.037 13.3 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase NodS PF05401.11 PIK59776.1 - 0.03 14.0 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PCMT PF01135.19 PIK59776.1 - 0.034 13.9 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Dynein_light PF01221.18 PIK59777.1 - 2.7e-37 127.0 3.2 3.5e-37 126.6 3.2 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 SET PF00856.28 PIK59778.1 - 0.019 15.4 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 SET domain TFIIF_alpha PF05793.12 PIK59779.1 - 2.5e-100 336.6 60.5 3e-100 336.3 60.5 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Copine PF07002.16 PIK59780.1 - 5.7e-55 186.1 0.0 7.7e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 PIK59780.1 - 2e-11 44.4 0.0 3.2e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2771 PF10969.8 PIK59780.1 - 0.12 12.4 0.0 8.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2771) BP28CT PF08146.12 PIK59781.1 - 1.8e-39 135.1 0.3 1.8e-39 135.1 0.3 5.2 5 1 2 7 7 7 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 PIK59781.1 - 1.1e-23 83.8 3.5 1.1e-23 83.8 3.5 7.4 9 3 0 9 9 9 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 PIK59781.1 - 1.1e-09 38.5 1.8 0.42 11.0 0.0 7.3 6 0 0 6 6 6 2 HEAT repeats HEAT PF02985.22 PIK59781.1 - 2.3e-08 33.6 1.0 1.7 9.1 0.0 8.1 7 0 0 7 7 7 1 HEAT repeat DUF5071 PF16804.5 PIK59781.1 - 0.0024 18.1 0.9 0.063 13.5 0.1 3.9 3 0 0 3 3 2 1 Domain of unknown function (DUF5071) Vac14_Fab1_bd PF12755.7 PIK59781.1 - 0.014 15.9 1.2 7.8 7.2 0.0 4.3 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 PIK59781.1 - 0.038 14.5 8.3 7 7.3 0.0 6.5 8 0 0 8 8 6 0 HEAT-like repeat LuxT_C PF18285.1 PIK59781.1 - 0.049 14.2 0.9 10 6.8 0.1 4.2 3 0 0 3 3 3 0 Tetracycline repressor LuxT C-terminal domain Cnd1 PF12717.7 PIK59781.1 - 0.067 13.2 19.3 2.2 8.3 0.1 7.0 4 2 3 7 7 7 0 non-SMC mitotic condensation complex subunit 1 RbsD_FucU PF05025.13 PIK59781.1 - 0.14 12.6 1.2 1 9.8 0.1 2.9 3 0 0 3 3 2 0 RbsD / FucU transport protein family CLASP_N PF12348.8 PIK59781.1 - 2.9 7.4 11.0 0.5 9.9 0.2 4.6 4 1 1 5 5 5 0 CLASP N terminal V-set PF07686.17 PIK59783.1 - 3.8e-13 49.6 1.4 2.8e-06 27.5 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK59783.1 - 9.2e-10 39.0 6.5 0.00072 20.1 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK59783.1 - 2.4e-08 34.0 3.9 0.0049 17.0 0.0 4.4 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK59783.1 - 4e-08 33.2 1.3 0.01 15.9 0.1 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK59783.1 - 2.7e-06 27.4 1.3 0.00045 20.2 0.0 3.1 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK59783.1 - 7.7e-05 23.0 8.1 0.044 14.1 0.1 4.4 4 0 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.5 PIK59783.1 - 0.0015 18.5 0.2 0.0084 16.2 0.1 2.4 2 1 0 2 2 2 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 PIK59783.1 - 0.088 12.6 1.2 10 6.0 0.1 2.7 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 CarbopepD_reg_2 PF13715.6 PIK59783.1 - 0.12 12.4 0.3 0.62 10.1 0.1 2.3 2 0 0 2 2 2 0 CarboxypepD_reg-like domain RVT_1 PF00078.27 PIK59784.1 - 1.1e-20 74.1 0.1 1.8e-20 73.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK59784.1 - 7.7e-20 70.8 0.1 1.7e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK59784.1 - 6.1e-10 39.3 0.0 1.4e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CheR PF01739.18 PIK59784.1 - 0.095 12.2 0.1 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain LRR_6 PF13516.6 PIK59785.1 - 3.1e-31 104.8 19.1 7.2e-05 22.5 0.3 9.0 9 0 0 9 9 9 7 Leucine Rich repeat rve PF00665.26 PIK59785.1 - 1.7e-15 57.3 0.0 3.1e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59785.1 - 3.1e-15 56.0 0.8 6.5e-15 55.0 0.8 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain LRR_1 PF00560.33 PIK59785.1 - 9.8e-10 37.6 0.1 25 6.0 0.0 8.0 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.7 PIK59785.1 - 0.00042 20.6 17.0 0.04 14.4 0.8 5.0 3 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK59785.1 - 0.2 11.4 19.8 0.2 11.4 3.8 5.5 3 2 2 5 5 5 0 Leucine rich repeat EF-hand_1 PF00036.32 PIK59786.1 - 1.2e-08 33.9 6.3 0.00016 21.0 0.6 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK59786.1 - 1.2e-06 28.8 3.9 3.4e-06 27.4 3.9 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 PIK59786.1 - 1.8e-05 24.5 5.1 0.0047 16.7 0.7 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK59786.1 - 8.4e-05 22.2 8.4 0.00068 19.4 0.6 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 PIK59786.1 - 0.0044 16.5 12.2 0.055 13.0 0.5 2.9 3 0 0 3 3 3 2 EF hand DAG_kinase_N PF14513.6 PIK59786.1 - 0.02 15.1 0.1 0.028 14.6 0.1 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus C1q PF00386.21 PIK59787.1 - 6e-26 91.1 0.1 7.3e-26 90.9 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 PIK59787.1 - 1.5e-05 24.6 18.9 3.2e-05 23.6 18.9 1.5 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 PIK59787.1 - 1.6e-05 24.8 0.0 2.2e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain Pkinase PF00069.25 PIK59788.1 - 7.5e-05 22.2 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 PIK59789.1 - 1.9e-50 171.7 0.0 2.2e-49 168.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59789.1 - 2.2e-28 99.3 0.0 3.4e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59789.1 - 1.5e-06 27.8 0.0 2.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK59789.1 - 1.4e-05 24.0 0.0 2.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 PIK59789.1 - 0.032 14.2 0.1 0.44 10.4 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Neur_chan_LBD PF02931.23 PIK59790.1 - 2.9e-24 85.7 0.0 4.8e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK59790.1 - 7.5e-07 29.4 0.0 1.1e-06 28.9 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region YesK PF14150.6 PIK59790.1 - 0.08 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 YesK-like protein PH PF00169.29 PIK59791.1 - 1.6e-06 28.5 0.1 3.3e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 PIK59791.1 - 0.058 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain CSN5_C PF18323.1 PIK59794.1 - 2.8 8.9 8.2 0.99 10.4 0.2 2.7 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain LRR_9 PF14580.6 PIK59795.1 - 4.4e-08 32.8 0.9 9.8e-07 28.4 0.9 2.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 PIK59795.1 - 4.8e-07 29.4 6.4 0.0017 18.0 1.7 3.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK59795.1 - 3.8e-05 23.9 7.2 0.053 14.0 2.3 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK59795.1 - 0.13 12.3 0.2 3.7 7.8 0.1 2.7 2 0 0 2 2 2 0 Leucine Rich repeat AP3D1 PF06375.11 PIK59795.1 - 0.51 10.6 25.1 0.83 9.9 4.6 3.3 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 Eapp_C PF10238.9 PIK59795.1 - 1.3 9.1 13.2 0.98 9.5 0.7 3.2 3 0 0 3 3 3 0 E2F-associated phosphoprotein DUF1619 PF07773.11 PIK59796.1 - 6.9e-05 22.9 2.6 0.071 13.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) DUF1619 PF07773.11 PIK59797.1 - 6.7e-17 62.4 3.6 1.1e-10 41.9 6.6 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) E1-E2_ATPase PF00122.20 PIK59798.1 - 1.9e-28 99.2 4.2 9.2e-26 90.5 1.0 2.3 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 PIK59798.1 - 3.6e-17 61.8 0.6 6.8e-16 57.7 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DNA_ligase_OB PF03120.16 PIK59798.1 - 0.11 12.4 2.6 4.7 7.2 0.1 2.5 1 1 1 2 2 2 0 NAD-dependent DNA ligase OB-fold domain E1-E2_ATPase PF00122.20 PIK59799.1 - 5.7e-09 35.7 1.2 9e-09 35.1 0.4 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 PIK59799.1 - 0.016 15.5 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK59800.1 - 2.6e-12 46.7 0.1 3.6e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 PIK59801.1 - 2.5e-15 57.3 0.2 2.3e-06 28.0 0.0 2.0 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 PIK59801.1 - 4.2e-07 30.0 0.4 1.2e-05 25.3 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 PIK59801.1 - 3.9e-06 27.4 0.3 9e-06 26.2 0.3 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 PIK59802.1 - 5.5e-10 39.2 0.0 9.7e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus RNase_P_Rpp14 PF01900.19 PIK59803.1 - 9.4e-16 57.9 0.6 1.6e-14 54.0 0.6 2.2 1 1 0 1 1 1 1 Rpp14/Pop5 family zf-C2H2 PF00096.26 PIK59804.1 - 0.00043 20.6 2.2 0.00084 19.7 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK59804.1 - 0.0021 18.8 0.4 0.005 17.6 0.4 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 PIK59804.1 - 0.022 15.1 0.5 0.04 14.3 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK59804.1 - 0.05 13.9 0.1 0.087 13.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK59804.1 - 0.13 12.3 0.2 0.23 11.5 0.2 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK59805.1 - 6.6e-19 67.2 48.5 0.00027 21.2 0.6 6.8 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK59805.1 - 2.6e-16 59.2 37.2 2.6e-06 27.6 0.5 6.9 7 0 0 7 7 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK59805.1 - 5.5e-15 54.8 41.6 0.0057 17.4 0.5 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK59805.1 - 0.0075 16.5 21.8 0.84 10.0 0.0 6.1 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 PIK59805.1 - 0.028 14.3 2.3 0.028 14.3 2.3 3.8 3 1 1 4 4 3 0 SprT-like zinc ribbon domain zf-C2H2_9 PF16293.5 PIK59805.1 - 0.045 13.6 1.1 1.2 9.1 0.2 3.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.11 PIK59805.1 - 0.073 12.9 0.1 0.073 12.9 0.1 3.9 2 2 3 5 5 4 0 GAGA factor zf-met PF12874.7 PIK59805.1 - 0.074 13.5 0.2 0.074 13.5 0.2 6.3 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK59805.1 - 0.12 12.5 23.5 7.1 6.8 0.2 5.1 3 1 1 5 5 5 0 Zinc ribbon domain HemX PF04375.14 PIK59805.1 - 0.16 11.2 3.1 0.26 10.5 3.1 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Zn-C2H2_12 PF18112.1 PIK59805.1 - 0.27 11.7 6.4 1.9 9.0 0.1 4.5 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain MetOD2 PF18548.1 PIK59805.1 - 0.3 11.2 3.6 0.34 11.0 1.7 2.1 2 0 0 2 2 2 0 Metanogen output domain 2 zinc_ribbon_15 PF17032.5 PIK59805.1 - 0.32 11.8 13.9 3.9 8.3 1.2 3.8 3 1 0 3 3 3 0 zinc-ribbon family Spectrin PF00435.21 PIK59805.1 - 0.37 11.3 5.3 0.074 13.5 1.1 2.1 2 0 0 2 2 1 0 Spectrin repeat zf_UBZ PF18439.1 PIK59805.1 - 1.1 8.9 16.9 2.7 7.6 0.1 6.1 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 PIK59805.1 - 1.3 9.7 22.7 23 5.7 9.6 5.3 2 1 3 5 5 4 0 Zinc finger C2H2-type, 3 repeats Desulfoferrod_N PF06397.12 PIK59805.1 - 2 8.1 11.5 22 4.7 0.9 4.0 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain C1_4 PF07975.12 PIK59805.1 - 3.7 7.9 19.6 23 5.3 4.3 4.5 3 1 1 4 4 4 0 TFIIH C1-like domain zf-C2H2_6 PF13912.6 PIK59805.1 - 4.2 7.5 36.6 0.36 10.9 0.9 7.0 7 0 0 7 7 7 0 C2H2-type zinc finger zf-Di19 PF05605.12 PIK59805.1 - 4.7 7.6 26.8 1 9.7 1.7 4.0 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding DER1 PF04511.15 PIK59806.1 - 2e-32 112.7 3.2 2.2e-32 112.6 3.2 1.0 1 0 0 1 1 1 1 Der1-like family Phage_holin_5_2 PF16079.5 PIK59806.1 - 0.1 12.9 0.8 13 6.2 0.1 2.4 1 1 1 2 2 2 0 Phage holin family Hol44, in holin superfamily V GDPD PF03009.17 PIK59807.1 - 7.7e-26 91.4 0.3 2.3e-25 89.8 0.3 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 PIK59807.1 - 1.6e-06 28.3 0.1 2.7e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Thioredoxin_9 PF14595.6 PIK59807.1 - 0.0045 16.8 0.3 0.0095 15.7 0.3 1.5 1 0 0 1 1 1 1 Thioredoxin PIG-S PF10510.9 PIK59808.1 - 8.9e-128 427.3 1.3 1.2e-127 426.9 1.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein DUF5641 PF18701.1 PIK59808.1 - 4e-29 100.6 5.2 8.4e-29 99.6 5.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 PIK59808.1 - 4.6e-05 23.4 0.6 0.0001 22.3 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK59808.1 - 0.00019 21.6 0.0 0.00052 20.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MA3 PF02847.17 PIK59808.1 - 0.094 12.7 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 MA3 domain zf-H2C2 PF09337.10 PIK59808.1 - 0.11 12.8 0.2 0.25 11.6 0.2 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Peptidase_A17 PF05380.13 PIK59809.1 - 4e-54 183.0 0.0 6.9e-54 182.2 0.0 1.4 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 PIK59809.1 - 1e-08 35.2 0.0 1.8e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) IML1 PF12257.8 PIK59810.1 - 1.7e-89 299.8 0.1 3e-89 298.9 0.1 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 PIK59810.1 - 1.5e-06 28.1 0.1 4e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RNA_pol_L_2 PF13656.6 PIK59811.1 - 6.9e-28 96.2 0.0 9.5e-28 95.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 PIK59811.1 - 7.6e-12 44.5 0.0 1.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Cas_DxTHG PF09455.10 PIK59812.1 - 0.061 12.9 0.7 0.071 12.7 0.7 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family DUF4239 PF14023.6 PIK59812.1 - 0.14 11.8 0.3 0.18 11.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) zf-C2H2_4 PF13894.6 PIK59813.1 - 7.5e-07 29.5 15.3 0.15 13.0 0.9 3.7 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK59813.1 - 2.3e-06 27.7 17.3 0.0091 16.4 0.7 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK59813.1 - 0.002 18.4 13.3 0.0049 17.2 0.7 3.9 4 1 0 4 4 3 1 Zinc-finger double domain zf-Sec23_Sec24 PF04810.15 PIK59813.1 - 0.014 15.4 0.3 1.9 8.6 0.0 3.0 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger PriA_CRR PF18319.1 PIK59813.1 - 0.057 13.4 1.2 0.057 13.4 1.2 2.5 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain PyrI_C PF02748.15 PIK59813.1 - 0.086 12.8 2.1 0.88 9.5 0.2 2.8 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FYVE PF01363.21 PIK59813.1 - 0.13 12.5 9.0 1.1 9.4 8.1 2.7 1 1 1 2 2 2 0 FYVE zinc finger zf_UBZ PF18439.1 PIK59813.1 - 0.21 11.2 1.4 0.73 9.5 0.1 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 PIK59813.1 - 0.23 11.5 14.5 1.3 9.1 2.5 3.5 2 1 2 4 4 4 0 BED zinc finger zf-C2H2_2 PF12756.7 PIK59813.1 - 0.51 10.7 7.7 15 6.0 0.6 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) C1_2 PF03107.16 PIK59813.1 - 0.55 10.6 5.5 4.6 7.6 0.1 3.2 2 1 1 3 3 3 0 C1 domain DUF3449 PF11931.8 PIK59813.1 - 1.6 8.5 7.9 4.3 7.1 0.1 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF3449) Zf_RING PF16744.5 PIK59813.1 - 2.6 8.2 6.8 66 3.7 0.1 3.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-UBP PF02148.19 PIK59813.1 - 8.2 6.8 7.5 43 4.5 7.5 2.2 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-H2C2_2 PF13465.6 PIK59814.1 - 3.3e-20 71.5 20.6 1.4e-09 37.9 0.8 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK59814.1 - 9e-08 32.3 27.1 0.0091 16.8 2.5 4.5 4 1 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK59814.1 - 3.5e-05 24.0 33.3 0.16 12.5 4.2 4.8 4 2 0 4 4 4 3 Zinc finger, C2H2 type Zn-ribbon_8 PF09723.10 PIK59814.1 - 0.0076 16.3 7.3 0.12 12.5 0.8 2.7 2 2 0 2 2 2 1 Zinc ribbon domain zf-BED PF02892.15 PIK59814.1 - 0.0089 16.0 28.1 1.5 8.9 3.7 4.2 1 1 2 3 3 3 2 BED zinc finger Elf1 PF05129.13 PIK59814.1 - 0.017 15.2 4.2 0.017 15.2 4.2 2.8 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like zf-CHCC PF10276.9 PIK59814.1 - 0.033 14.2 0.1 0.033 14.2 0.1 3.5 4 0 0 4 4 4 0 Zinc-finger domain C1_4 PF07975.12 PIK59814.1 - 0.035 14.3 11.1 1.5 9.1 0.2 3.0 2 1 1 3 3 3 0 TFIIH C1-like domain DUF3268 PF11672.8 PIK59814.1 - 0.046 14.1 2.0 0.046 14.1 2.0 2.2 2 0 0 2 2 2 0 zinc-finger-containing domain C1_2 PF03107.16 PIK59814.1 - 0.046 14.0 19.9 2.7 8.4 4.0 4.0 1 1 2 3 3 3 0 C1 domain Zf_RING PF16744.5 PIK59814.1 - 0.064 13.4 17.1 1.9 8.6 0.9 3.9 1 1 2 3 3 3 0 KIAA1045 RING finger CTV_P23 PF04808.12 PIK59814.1 - 0.069 12.7 1.7 0.075 12.6 1.7 1.1 1 0 0 1 1 1 0 Citrus tristeza virus (CTV) P23 protein Desulfoferrod_N PF06397.12 PIK59814.1 - 0.077 12.6 11.9 0.42 10.3 0.2 3.8 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_jaz PF12171.8 PIK59814.1 - 0.2 12.0 16.8 0.85 10.0 2.3 4.7 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK59814.1 - 0.33 11.4 18.5 0.47 10.9 2.0 4.4 4 1 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK59814.1 - 0.36 10.9 32.5 2.3 8.3 0.2 6.4 6 1 0 6 6 5 0 C2H2-type zinc finger YyzF PF14116.6 PIK59814.1 - 0.5 10.4 10.7 13 5.9 0.3 3.8 3 1 1 4 4 4 0 YyzF-like protein zf_UBZ PF18439.1 PIK59814.1 - 0.78 9.4 12.2 6.6 6.4 0.4 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 PIK59814.1 - 1.1 9.6 20.2 0.27 11.6 1.7 3.2 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) DZR PF12773.7 PIK59814.1 - 1.4 9.0 13.6 3e+02 1.5 13.6 2.8 1 1 0 1 1 1 0 Double zinc ribbon Ribosomal_L37ae PF01780.19 PIK59814.1 - 1.8 8.7 16.0 3.5 7.8 2.6 3.3 1 1 2 3 3 3 0 Ribosomal L37ae protein family TFIIS_C PF01096.18 PIK59814.1 - 1.9 8.4 13.5 2.7 7.9 3.7 3.7 3 1 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-3CxxC_2 PF17180.4 PIK59814.1 - 2.4 8.9 15.1 5.1 7.9 0.7 2.9 2 1 0 2 2 2 0 Zinc-binding domain zf_C2H2_ZHX PF18387.1 PIK59814.1 - 3.1 7.5 9.2 4.6 6.9 0.1 2.8 3 0 0 3 3 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3449 PF11931.8 PIK59814.1 - 3.9 7.2 9.8 22 4.8 0.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) zf-nanos PF05741.13 PIK59814.1 - 4.5 7.6 15.2 3.4 8.0 1.6 4.1 4 0 0 4 4 4 0 Nanos RNA binding domain SIR2 PF02146.17 PIK59814.1 - 5.6 6.9 8.1 11 5.9 7.8 1.7 1 1 0 1 1 1 0 Sir2 family GLTP PF08718.11 PIK59815.1 - 1.2e-35 123.0 0.0 1.6e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Fibrinogen_C PF00147.18 PIK59816.1 - 7.3e-46 156.7 1.5 9.8e-46 156.3 1.5 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59816.1 - 1.3e-06 28.3 7.5 1.3e-06 28.3 7.5 2.5 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59816.1 - 1.8e-05 24.8 8.6 1.8e-05 24.8 8.6 3.0 2 1 0 2 2 2 1 EGF domain TIL PF01826.17 PIK59816.1 - 6.2 7.1 21.4 2.7 8.3 7.8 3.2 2 1 1 3 3 3 0 Trypsin Inhibitor like cysteine rich domain GBP_C PF02841.14 PIK59817.1 - 0.0029 17.0 5.4 0.11 11.9 0.2 2.4 2 0 0 2 2 2 2 Guanylate-binding protein, C-terminal domain DUF4897 PF16238.5 PIK59817.1 - 0.22 11.3 1.9 0.54 10.1 0.6 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4897) Nod1 PF17114.5 PIK59817.1 - 0.89 9.7 3.8 7.3 6.7 1.1 3.2 2 2 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 GBP PF02263.19 PIK59818.1 - 4.5e-36 124.4 0.4 1.7e-35 122.5 0.0 2.0 3 0 0 3 3 3 1 Guanylate-binding protein, N-terminal domain Med29 PF11568.8 PIK59818.1 - 0.029 14.6 0.7 0.11 12.8 0.7 2.0 1 0 0 1 1 1 0 Mediator complex subunit 29 DNA_pol_lambd_f PF10391.9 PIK59818.1 - 6.7 6.6 5.2 14 5.7 0.0 3.3 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda GBP PF02263.19 PIK59820.1 - 9.3e-27 93.9 0.0 1.1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain CobU PF02283.16 PIK59820.1 - 0.032 13.8 0.0 0.077 12.6 0.0 1.6 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase GBP PF02263.19 PIK59821.1 - 2e-31 109.2 0.0 3.5e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 PIK59821.1 - 1.5e-05 24.6 29.3 1.9e-05 24.3 5.6 2.7 2 1 1 3 3 3 2 Guanylate-binding protein, C-terminal domain TFIID_NTD2 PF04494.15 PIK59821.1 - 0.049 13.9 2.0 0.14 12.4 2.0 1.8 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain RNA_helicase PF00910.22 PIK59821.1 - 0.29 11.6 1.7 9.5 6.7 0.0 3.7 2 1 2 4 4 4 0 RNA helicase GBP PF02263.19 PIK59822.1 - 4.8e-32 111.2 0.0 4.8e-32 111.2 0.0 3.2 4 0 0 4 4 4 1 Guanylate-binding protein, N-terminal domain MHC_I_3 PF16497.5 PIK59822.1 - 0.00055 19.5 1.0 0.071 12.6 0.0 2.8 3 0 0 3 3 3 1 MHC-I family domain LPD29 PF18847.1 PIK59822.1 - 0.015 16.2 0.4 10 7.2 0.0 3.7 3 0 0 3 3 3 0 Large polyvalent protein associated domain 29 CobU PF02283.16 PIK59822.1 - 0.065 12.8 3.5 0.21 11.2 0.0 3.4 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase CENP-L PF13092.6 PIK59822.1 - 0.16 12.2 1.1 0.83 9.8 1.1 2.3 1 1 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 QslA_E PF18226.1 PIK59822.1 - 0.22 11.4 0.3 4.1 7.4 0.1 2.4 2 0 0 2 2 2 0 LasR-specific antiactivator QslA chain E PTPS_related PF10131.9 PIK59822.1 - 0.31 9.3 2.4 8.1 4.6 0.2 2.1 2 0 0 2 2 2 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF4530 PF15039.6 PIK59822.1 - 0.7 10.0 10.0 0.45 10.7 0.2 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4530) Mt_ATP-synt_D PF05873.12 PIK59822.1 - 1.9 8.3 21.6 0.54 10.1 0.7 4.9 4 0 0 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) RbsD_FucU PF05025.13 PIK59822.1 - 6.3 7.2 13.9 0.97 9.9 0.3 4.1 4 1 0 4 4 4 0 RbsD / FucU transport protein family PIF1 PF05970.14 PIK59824.1 - 1.6e-21 76.9 0.0 2.1e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 PIK59824.1 - 1.7e-15 57.3 0.0 2.4e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK59824.1 - 7.8e-14 52.2 0.0 1.1e-13 51.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK59824.1 - 0.00014 22.1 0.0 0.00026 21.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 PIK59824.1 - 0.0054 17.1 0.0 0.014 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 PIK59824.1 - 0.0085 16.0 1.0 0.098 12.6 0.2 2.6 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 PIK59824.1 - 0.015 15.1 0.1 0.067 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 PIK59824.1 - 0.018 15.5 0.0 0.032 14.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK59824.1 - 0.025 14.9 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 PIK59824.1 - 0.028 14.1 0.0 0.093 12.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 PIK59824.1 - 0.033 14.1 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 NTPase Viral_helicase1 PF01443.18 PIK59824.1 - 0.047 13.4 0.0 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.9 PIK59824.1 - 0.049 12.5 0.0 0.12 11.2 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 PIK59824.1 - 0.06 13.1 0.0 0.18 11.6 0.0 1.8 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 PIK59824.1 - 0.064 12.7 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Bac_DnaA PF00308.18 PIK59824.1 - 0.087 12.6 0.3 6.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein Zeta_toxin PF06414.12 PIK59824.1 - 0.11 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 PIK59824.1 - 0.14 12.8 0.0 0.21 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 PIK59824.1 - 0.19 11.7 0.0 9.3 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RVT_1 PF00078.27 PIK59825.1 - 5.7e-18 65.2 0.0 7.5e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 PIK59826.1 - 0.0023 17.5 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Squash PF00299.18 PIK59826.1 - 0.8 9.8 5.9 5.7 7.0 0.5 2.8 2 0 0 2 2 2 0 Squash family serine protease inhibitor zf-CCHC PF00098.23 PIK59827.1 - 1.9e-05 24.5 15.2 0.0023 17.9 3.3 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59827.1 - 3e-05 23.7 14.0 0.2 11.4 0.4 3.6 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59827.1 - 0.0021 17.8 0.2 0.0021 17.8 0.2 3.0 3 0 0 3 3 3 2 Zinc knuckle IBR PF01485.21 PIK59827.1 - 0.99 9.7 12.0 0.5 10.6 6.7 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain TSC22 PF01166.18 PIK59828.1 - 0.0032 17.7 1.1 0.0073 16.6 1.1 1.6 1 0 0 1 1 1 1 TSC-22/dip/bun family TPR_MLP1_2 PF07926.12 PIK59828.1 - 0.01 15.9 2.6 0.018 15.1 2.0 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 PIK59828.1 - 0.017 14.5 0.2 0.026 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) BEN PF10523.9 PIK59828.1 - 0.022 15.0 0.0 0.074 13.3 0.0 1.8 2 0 0 2 2 2 0 BEN domain FliD_C PF07195.12 PIK59828.1 - 0.038 13.4 0.3 0.054 12.9 0.3 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Herpes_UL6 PF01763.16 PIK59828.1 - 0.054 12.0 0.2 0.072 11.6 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like HTH_21 PF13276.6 PIK59829.1 - 0.00092 19.3 0.3 0.003 17.6 0.1 2.0 2 0 0 2 2 2 1 HTH-like domain HTH_Tnp_Tc3_2 PF01498.18 PIK59829.1 - 0.091 13.0 1.1 3.4 8.0 0.2 2.6 2 0 0 2 2 2 0 Transposase HTH_30 PF13556.6 PIK59829.1 - 4.5 7.1 6.6 1.9 8.3 0.6 2.6 3 0 0 3 3 3 0 PucR C-terminal helix-turn-helix domain zf-CCHC PF00098.23 PIK59832.1 - 6.9e-08 32.2 15.1 0.00041 20.3 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK59832.1 - 0.0002 21.1 7.7 0.061 13.2 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK59832.1 - 0.0088 16.0 15.9 0.16 12.0 1.3 3.7 2 1 2 4 4 4 2 Zinc knuckle zf-CCHC_4 PF14392.6 PIK59832.1 - 0.009 15.7 11.1 3.1 7.6 0.4 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK59832.1 - 0.014 15.2 0.2 0.014 15.2 0.2 3.4 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK59832.1 - 0.014 15.1 0.8 0.014 15.1 0.8 2.6 1 1 1 2 2 2 0 C2H2 zinc-finger Sof1 PF04158.14 PIK59833.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Sof1-like domain Tail_spike_N PF18668.1 PIK59835.1 - 0.0024 17.7 0.0 0.0065 16.3 0.0 1.7 1 0 0 1 1 1 1 Tail spike TSP1/Gp66 receptor binding N-terminal domain RVT_1 PF00078.27 PIK59836.1 - 2.2e-27 96.0 0.1 3.5e-27 95.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK59837.1 - 1.1e-36 124.9 0.0 2.1e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK59837.1 - 1e-33 115.7 0.0 2e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK59837.1 - 8.8e-21 74.3 0.0 1.9e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK59837.1 - 1.4e-08 34.7 0.5 3.6e-08 33.4 0.5 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK59837.1 - 0.0014 18.4 0.0 0.0038 17.0 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK59837.1 - 0.13 12.5 0.0 0.37 11.0 0.0 1.7 2 0 0 2 2 2 0 DDE domain Ferrochelatase PF00762.19 PIK59837.1 - 0.16 11.1 0.0 5 6.1 0.0 2.7 2 1 1 3 3 3 0 Ferrochelatase NACHT PF05729.12 PIK59838.1 - 3.1e-05 24.0 0.0 6.9e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain E6 PF00518.17 PIK59839.1 - 0.0015 18.9 2.4 0.0029 18.0 2.2 1.7 2 0 0 2 2 2 1 Early Protein (E6) TilS PF09179.11 PIK59839.1 - 0.03 14.8 0.2 0.056 13.9 0.2 1.4 1 0 0 1 1 1 0 TilS substrate binding domain Cut8 PF08559.10 PIK59839.1 - 0.056 13.0 0.9 0.067 12.8 0.9 1.3 1 1 0 1 1 1 0 Cut8, nuclear proteasome tether protein Ge1_WD40 PF16529.5 PIK59840.1 - 1.8e-90 303.3 0.0 2.9e-90 302.6 0.0 1.3 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 PIK59840.1 - 6.5e-11 42.6 1.2 8.8e-06 26.4 0.0 5.4 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK59840.1 - 0.089 13.1 0.0 0.37 11.1 0.0 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain HSBP1 PF06825.12 PIK59840.1 - 0.3 11.0 14.5 0.41 10.5 1.2 4.1 4 0 0 4 4 4 0 Heat shock factor binding protein 1 PIN_2 PF10130.9 PIK59840.1 - 3.3 7.9 5.5 0.6 10.3 0.8 2.1 2 0 0 2 2 2 0 PIN domain DUF1515 PF07439.11 PIK59840.1 - 6.4 6.8 6.4 4.6 7.3 1.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) ECH_1 PF00378.20 PIK59841.1 - 8e-43 146.6 0.0 9.5e-43 146.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK59841.1 - 1.2e-21 77.5 0.2 4.9e-20 72.3 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Pkinase PF00069.25 PIK59842.1 - 4.6e-40 137.6 2.6 9.4e-30 103.8 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59842.1 - 8.3e-23 81.0 0.0 5.1e-19 68.6 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase DivIC PF04977.15 PIK59842.1 - 4.2 7.2 10.8 14 5.6 10.8 1.9 1 0 0 1 1 1 0 Septum formation initiator zf-C3HC4_2 PF13923.6 PIK59843.1 - 6.7e-10 38.6 5.6 2.4e-09 36.9 5.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK59843.1 - 6.6e-09 35.5 4.7 6.6e-09 35.5 4.7 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK59843.1 - 6.6e-07 29.3 6.9 6.6e-07 29.3 6.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 PIK59843.1 - 1.5e-06 28.2 5.2 1.5e-06 28.2 5.2 2.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 PIK59843.1 - 3.4e-06 26.8 1.4 3.4e-06 26.8 1.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK59843.1 - 3.7e-06 27.2 6.1 3.7e-06 27.2 6.1 2.9 3 1 0 3 3 1 1 Ring finger domain zf-TRAF_2 PF15965.5 PIK59843.1 - 7.8e-05 23.1 9.4 7.8e-05 23.1 9.4 2.5 2 1 1 3 3 2 1 TRAF-like zinc-finger zf-TRAF PF02176.18 PIK59843.1 - 0.00023 21.8 5.4 0.00023 21.8 5.4 3.0 4 0 0 4 4 2 1 TRAF-type zinc finger zf-RING_6 PF14835.6 PIK59843.1 - 0.00033 20.5 2.1 0.00033 20.5 2.1 2.5 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 PIK59843.1 - 0.00074 19.4 3.7 0.00074 19.4 3.7 2.4 2 1 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK59843.1 - 0.00093 19.0 4.3 0.0028 17.5 4.3 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Sina PF03145.16 PIK59843.1 - 0.0011 19.0 3.7 0.0011 19.0 3.7 2.3 1 1 1 2 2 2 2 Seven in absentia protein family zf-rbx1 PF12678.7 PIK59843.1 - 0.0066 16.7 6.9 0.0066 16.7 6.9 3.3 2 2 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 PIK59843.1 - 0.018 15.2 0.0 0.048 13.8 0.0 1.8 1 0 0 1 1 1 0 U-box domain FAM184 PF15665.5 PIK59843.1 - 0.049 13.4 3.9 0.07 12.9 3.9 1.2 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B DUF1640 PF07798.11 PIK59843.1 - 0.65 10.0 6.7 0.38 10.8 3.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) zf-C2H2_4 PF13894.6 PIK59844.1 - 0.026 15.3 16.8 4.2 8.5 1.3 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK59844.1 - 0.042 14.3 1.6 0.042 14.3 1.6 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-UDP PF14569.6 PIK59844.1 - 7.3 6.8 7.4 12 6.1 1.5 3.3 3 0 0 3 3 3 0 Zinc-binding RING-finger Copine PF07002.16 PIK59845.1 - 7.6e-90 300.1 0.0 1.1e-89 299.7 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 PIK59845.1 - 4.6e-20 71.8 0.1 5.3e-11 42.7 0.0 2.5 1 1 1 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 PIK59845.1 - 7e-08 32.8 0.1 1.9e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus A2M_BRD PF07703.14 PIK59846.1 - 3.8e-24 85.6 0.0 5.8e-24 85.0 0.0 1.3 1 1 0 1 1 1 1 Alpha-2-macroglobulin bait region domain Imm58 PF15581.6 PIK59846.1 - 0.2 11.8 0.0 0.39 10.8 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 58 TED_complement PF07678.14 PIK59847.1 - 9e-74 248.3 0.0 3.5e-53 180.7 0.0 2.1 1 1 1 2 2 2 2 A-macroglobulin TED domain A2M PF00207.22 PIK59847.1 - 3.3e-22 78.1 0.3 7.4e-22 77.0 0.3 1.6 1 1 0 1 1 1 1 Alpha-2-macroglobulin family Prenyltrans PF00432.21 PIK59847.1 - 0.0025 17.5 1.9 0.33 10.7 0.1 2.9 3 0 0 3 3 3 2 Prenyltransferase and squalene oxidase repeat FSA_C PF10479.9 PIK59848.1 - 1.1 7.3 4.9 1.5 6.9 4.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF2228 PF10228.9 PIK59849.1 - 6.2e-69 232.5 0.0 8.3e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) zf-CCHH PF10283.9 PIK59849.1 - 7.9e-12 44.9 4.8 1.4e-11 44.1 4.8 1.4 1 0 0 1 1 1 1 PBZ domain Phosducin PF02114.16 PIK59849.1 - 0.23 10.4 1.5 0.36 9.8 1.5 1.2 1 0 0 1 1 1 0 Phosducin zf-CCCH_2 PF14608.6 PIK59849.1 - 0.26 11.8 1.9 0.5 10.9 1.9 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger LIAS_N PF16881.5 PIK59850.1 - 4.1e-30 104.4 0.1 7.8e-30 103.5 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 PIK59850.1 - 1.2e-15 58.3 0.0 1.7e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily ROS_MUCR PF05443.11 PIK59850.1 - 0.025 14.6 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein DUF2250 PF10007.9 PIK59850.1 - 0.098 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) STAS PF01740.21 PIK59850.1 - 0.14 11.8 0.0 3.9 7.1 0.0 2.2 1 1 1 2 2 2 0 STAS domain HSP70 PF00012.20 PIK59851.1 - 2.6e-144 481.7 14.7 2.6e-143 478.4 0.4 2.4 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 PIK59851.1 - 1.7e-08 33.7 0.2 2.6e-08 33.1 0.2 1.2 1 0 0 1 1 1 1 MreB/Mbl protein SPC22 PF04573.12 PIK59852.1 - 1e-50 171.6 0.2 1.3e-50 171.3 0.2 1.0 1 0 0 1 1 1 1 Signal peptidase subunit MFS_1_like PF12832.7 PIK59853.1 - 2.3e-82 276.9 13.8 3e-82 276.6 13.8 1.0 1 0 0 1 1 1 1 MFS_1 like family Nuc_H_symport PF03825.16 PIK59853.1 - 1.6e-17 63.6 13.9 1.8e-14 53.6 7.1 2.0 2 0 0 2 2 2 2 Nucleoside H+ symporter MFS_1 PF07690.16 PIK59853.1 - 2.3e-14 53.1 33.2 2.2e-07 30.1 9.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 PIK59853.1 - 4.4e-07 29.0 12.5 0.0002 20.3 2.3 2.7 2 1 0 2 2 2 2 LacY proton/sugar symporter MFS_2 PF13347.6 PIK59853.1 - 8.4e-05 21.3 16.2 0.001 17.7 7.8 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein RhoGAP PF00620.27 PIK59854.1 - 5.8e-43 146.3 0.1 1.2e-42 145.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 PIK59854.1 - 1.9e-07 31.5 0.1 6.3e-07 29.9 0.1 1.9 1 0 0 1 1 1 1 PH domain BAR_3 PF16746.5 PIK59854.1 - 0.0062 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 BAR domain of APPL family DUF4801 PF16059.5 PIK59855.1 - 1.1e-13 50.9 10.1 2.8e-13 49.6 10.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4801) HLH PF00010.26 PIK59856.1 - 0.00064 19.6 3.2 0.0015 18.5 1.5 2.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Pkinase PF00069.25 PIK59858.1 - 2.6e-63 213.9 0.0 5.8e-61 206.2 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain DCX PF03607.17 PIK59858.1 - 3.1e-37 126.5 0.1 3.3e-17 62.4 0.0 2.5 2 0 0 2 2 2 2 Doublecortin Pkinase_Tyr PF07714.17 PIK59858.1 - 6.4e-30 104.3 0.0 9.6e-30 103.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK59858.1 - 0.0014 18.0 0.0 0.093 12.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK59858.1 - 0.0037 16.1 0.0 0.0072 15.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 PIK59858.1 - 0.0046 16.6 0.0 0.17 11.5 0.2 2.5 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 PIK59858.1 - 0.029 13.7 0.1 0.052 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 PIK59858.1 - 0.15 11.0 0.2 0.25 10.3 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase TPR_2 PF07719.17 PIK59859.1 - 5.8e-16 57.3 8.8 8.5e-05 22.4 0.1 4.5 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK59859.1 - 6.7e-16 57.4 1.8 3.9e-07 29.6 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 PIK59859.1 - 1.8e-11 43.5 0.5 0.00016 21.3 0.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_9 PF13371.6 PIK59859.1 - 6.1e-10 39.1 0.1 7.2e-09 35.7 0.1 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK59859.1 - 4.4e-09 36.8 0.2 6.8e-06 26.6 0.0 2.6 2 1 1 3 3 2 2 Tetratricopeptide repeat STI1 PF17830.1 PIK59859.1 - 7.5e-09 35.4 0.6 7.5e-09 35.4 0.6 2.2 3 0 0 3 3 2 1 STI1 domain TPR_14 PF13428.6 PIK59859.1 - 3.2e-08 33.7 0.1 0.036 14.9 0.0 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK59859.1 - 2e-07 30.7 7.8 0.00036 20.5 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK59859.1 - 3.4e-07 30.2 0.4 0.022 15.1 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK59859.1 - 6.8e-07 29.7 0.7 8.1e-06 26.3 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK59859.1 - 0.00018 21.0 0.0 0.0056 16.1 0.0 2.1 1 1 1 2 2 2 1 MalT-like TPR region TPR_15 PF13429.6 PIK59859.1 - 0.00071 18.9 0.1 0.16 11.2 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK59859.1 - 0.0021 18.6 2.9 4.8 8.0 0.1 4.0 4 1 0 4 4 3 1 Tetratricopeptide repeat NARP1 PF12569.8 PIK59859.1 - 0.0068 15.4 0.3 0.0068 15.4 0.3 2.5 1 1 1 2 2 1 1 NMDA receptor-regulated protein 1 TPR_12 PF13424.6 PIK59859.1 - 0.0068 16.7 3.2 0.4 11.0 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK59859.1 - 0.072 13.3 0.4 7.3 6.9 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Rrn6 PF10214.9 PIK59859.1 - 0.11 11.0 2.4 0.13 10.7 2.4 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TPR_7 PF13176.6 PIK59859.1 - 0.16 12.0 0.1 57 4.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Hrs_helical PF12210.8 PIK59859.1 - 0.62 10.6 7.2 9.2 6.9 4.7 2.3 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate XRN_N PF03159.18 PIK59859.1 - 0.95 8.8 3.7 1.6 8.1 3.7 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus TPR_10 PF13374.6 PIK59859.1 - 2.1 8.3 4.7 96 3.0 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2203 PF09969.9 PIK59859.1 - 2.9 8.6 6.7 8.1 7.2 6.7 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) PDCD2_C PF04194.13 PIK59859.1 - 8.8 6.4 11.2 0.83 9.7 0.4 2.4 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain DUF910 PF06014.11 PIK59860.1 - 0.044 13.8 0.1 0.084 12.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) OAS1_C PF10421.9 PIK59861.1 - 6.7e-11 42.0 0.0 9.2e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Ndr PF03096.14 PIK59861.1 - 0.045 12.4 0.0 0.058 12.1 0.0 1.1 1 0 0 1 1 1 0 Ndr family OAS1_C PF10421.9 PIK59862.1 - 5.2e-11 42.4 0.0 8.2e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Ndr PF03096.14 PIK59862.1 - 0.07 11.8 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family OAS1_C PF10421.9 PIK59863.1 - 5.6e-13 48.8 0.0 9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus SMODS PF18144.1 PIK59863.1 - 4.6e-08 33.4 0.1 1.3e-07 32.0 0.1 1.7 2 0 0 2 2 2 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 PIK59863.1 - 0.00066 19.9 0.0 0.0031 17.8 0.0 2.1 1 1 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 PIK59863.1 - 0.0018 18.1 0.1 0.0093 15.7 0.1 2.1 1 1 0 1 1 1 1 Nrap protein PAP/OAS-like domain Ndr PF03096.14 PIK59863.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.4 1 0 0 1 1 1 0 Ndr family DUF812 PF05667.11 PIK59864.1 - 7.2e-99 332.3 0.9 9.6e-99 331.9 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) NLE PF08154.12 PIK59864.1 - 0.0013 19.2 9.1 78 3.9 0.3 8.7 4 3 0 4 4 4 0 NLE (NUC135) domain DUF2203 PF09969.9 PIK59864.1 - 0.035 14.8 4.2 0.86 10.3 0.8 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) ADAM17_MPD PF16698.5 PIK59864.1 - 0.042 14.2 0.6 0.042 14.2 0.6 7.2 5 2 0 5 5 4 0 Membrane-proximal domain, switch, for ADAM17 DUF1640 PF07798.11 PIK59864.1 - 0.042 13.9 2.8 1.5 8.8 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) TGBp3 PF02495.17 PIK59864.1 - 0.1 12.3 1.3 15 5.3 0.4 3.5 2 0 0 2 2 2 0 Triple gene block 3 Tropomyosin_1 PF12718.7 PIK59864.1 - 0.68 10.1 14.1 0.15 12.2 5.2 2.2 2 0 0 2 2 2 0 Tropomyosin like TSC22 PF01166.18 PIK59864.1 - 1.3 9.4 8.0 0.92 9.9 0.6 4.2 3 1 1 4 4 4 0 TSC-22/dip/bun family YlqD PF11068.8 PIK59864.1 - 2.3 8.6 9.3 1.3 9.4 1.8 2.3 2 0 0 2 2 2 0 YlqD protein SOGA PF11365.8 PIK59864.1 - 2.5 9.3 7.7 0.13 13.4 1.1 2.2 2 0 0 2 2 2 0 Protein SOGA DUF4200 PF13863.6 PIK59864.1 - 2.9 8.3 12.5 0.25 11.7 6.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Uso1_p115_C PF04871.13 PIK59864.1 - 5.2 7.5 12.7 5.6 7.3 2.9 2.4 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GrpE PF01025.19 PIK59864.1 - 6 6.5 9.2 7.4 6.2 3.0 2.2 2 0 0 2 2 2 0 GrpE Prefoldin_2 PF01920.20 PIK59864.1 - 6.8 6.7 12.0 0.26 11.3 5.7 1.8 2 0 0 2 2 2 0 Prefoldin subunit DUF812 PF05667.11 PIK59865.1 - 1.6e-86 291.5 19.6 2e-86 291.2 19.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Mod_r PF07200.13 PIK59865.1 - 0.003 17.7 17.8 0.015 15.4 9.2 3.2 1 1 2 3 3 3 1 Modifier of rudimentary (Mod(r)) protein Latarcin PF10279.9 PIK59865.1 - 0.0036 17.7 8.7 0.052 14.0 0.4 3.3 1 1 1 2 2 2 1 Latarcin precursor ZapB PF06005.12 PIK59865.1 - 0.004 17.6 1.4 0.004 17.6 1.4 3.8 2 2 2 4 4 4 1 Cell division protein ZapB DUF948 PF06103.11 PIK59865.1 - 0.0049 17.1 7.0 1.2 9.5 0.1 3.6 2 1 2 4 4 4 1 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 PIK59865.1 - 0.011 16.0 19.0 0.15 12.3 7.7 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain zf-C4H2 PF10146.9 PIK59865.1 - 0.027 14.8 16.2 0.082 13.2 16.2 1.8 1 1 0 1 1 1 0 Zinc finger-containing protein Fez1 PF06818.15 PIK59865.1 - 0.065 13.7 14.1 0.066 13.7 13.4 1.4 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 PIK59865.1 - 0.075 12.4 8.3 0.092 12.1 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spectrin PF00435.21 PIK59865.1 - 0.092 13.2 14.8 0.85 10.1 0.5 3.1 1 1 2 3 3 3 0 Spectrin repeat Hemerythrin PF01814.23 PIK59865.1 - 0.15 12.7 3.1 2.6 8.7 0.0 2.5 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain Syntaxin-6_N PF09177.11 PIK59865.1 - 0.15 12.7 12.1 2.2 8.9 1.8 3.2 1 1 2 3 3 3 0 Syntaxin 6, N-terminal PI3K_P85_iSH2 PF16454.5 PIK59865.1 - 0.17 11.5 15.8 0.41 10.2 11.9 3.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Syntaxin_2 PF14523.6 PIK59865.1 - 0.19 12.1 12.9 32 5.0 12.7 3.3 1 1 1 2 2 2 0 Syntaxin-like protein TACC_C PF05010.14 PIK59865.1 - 0.34 10.7 18.2 0.19 11.5 8.1 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 PIK59865.1 - 0.35 10.9 10.0 1.8 8.6 1.0 2.3 1 1 1 2 2 2 0 Laminin Domain II SKA2 PF16740.5 PIK59865.1 - 0.49 10.2 8.9 2 8.2 2.3 3.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Sec66 PF09802.9 PIK59865.1 - 0.62 9.6 8.5 0.11 12.1 3.4 2.0 2 1 0 2 2 2 0 Preprotein translocase subunit Sec66 FlgN PF05130.12 PIK59865.1 - 0.64 10.5 11.5 2.2 8.8 5.0 2.5 1 1 1 2 2 2 0 FlgN protein Aminopep PF10023.9 PIK59865.1 - 0.8 9.0 6.0 0.65 9.3 4.9 1.4 1 1 0 1 1 1 0 Putative aminopeptidase YabA PF06156.13 PIK59865.1 - 0.89 10.2 14.6 0.92 10.2 0.8 2.7 1 1 2 3 3 3 0 Initiation control protein YabA DUF4047 PF13256.6 PIK59865.1 - 0.91 9.7 14.3 8.5 6.6 6.8 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) ISG65-75 PF11727.8 PIK59865.1 - 1.2 8.3 13.3 0.73 9.0 4.3 2.2 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF5082 PF16888.5 PIK59865.1 - 1.3 9.4 18.5 1.5 9.1 12.2 2.5 2 1 1 3 3 2 0 Domain of unknown function (DUF5082) FadA PF09403.10 PIK59865.1 - 1.4 9.4 18.9 0.1 13.1 10.0 2.5 1 1 1 2 2 2 0 Adhesion protein FadA RP-C_C PF11800.8 PIK59865.1 - 1.6 8.8 10.5 0.41 10.7 0.8 2.4 1 1 1 2 2 2 0 Replication protein C C-terminal region DUF2203 PF09969.9 PIK59865.1 - 1.7 9.4 11.6 12 6.6 0.5 3.0 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Jnk-SapK_ap_N PF09744.9 PIK59865.1 - 2 8.6 18.3 0.52 10.5 10.5 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1043 PF06295.12 PIK59865.1 - 2.4 8.2 9.7 1.9 8.5 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) BRE1 PF08647.11 PIK59865.1 - 3 8.0 22.2 0.12 12.5 8.4 3.1 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase DUF16 PF01519.16 PIK59865.1 - 3.2 8.3 17.0 58 4.2 0.1 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 PIK59865.1 - 3.3 7.9 13.2 3.8 7.7 8.7 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 PIK59865.1 - 3.3 7.7 12.4 5.7 7.0 1.9 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Sigma70_ner PF04546.13 PIK59865.1 - 3.3 7.5 15.1 3 7.7 11.3 2.3 1 1 1 2 2 2 0 Sigma-70, non-essential region Peptidase_M75 PF09375.10 PIK59865.1 - 3.6 7.0 6.8 1.6e+02 1.5 6.8 2.5 1 1 0 1 1 1 0 Imelysin DUF4200 PF13863.6 PIK59865.1 - 6 7.3 23.5 0.77 10.2 5.6 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) CENP-H PF05837.12 PIK59865.1 - 6.9 7.1 16.3 7.5 7.0 7.8 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) LMBR1 PF04791.16 PIK59865.1 - 7.2 5.4 9.3 9.2 5.0 9.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NYD-SP28_assoc PF14775.6 PIK59865.1 - 9.3 6.4 7.8 2.6 8.2 0.4 3.4 3 1 0 3 3 3 0 Sperm tail C-terminal domain Fibrinogen_C PF00147.18 PIK59866.1 - 5e-24 85.3 3.2 5.5e-24 85.2 3.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59867.1 - 7.5e-36 124.0 0.2 9.9e-36 123.6 0.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RRM_1 PF00076.22 PIK59868.1 - 2.7e-25 88.0 0.0 4.8e-16 58.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trnau1ap PF17654.1 PIK59868.1 - 3.6e-12 47.0 27.2 2.4e-11 44.4 27.2 2.0 1 1 0 1 1 1 1 Selenocysteine tRNA 1 associated proteins BRAP2 PF07576.12 PIK59868.1 - 0.012 15.9 0.0 0.3 11.3 0.0 2.4 2 0 0 2 2 2 0 BRCA1-associated protein 2 Limkain-b1 PF11608.8 PIK59868.1 - 0.046 13.8 0.0 4.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 BRCT_2 PF16589.5 PIK59870.1 - 5.7e-19 68.3 0.0 2.9e-07 30.8 0.0 3.7 3 0 0 3 3 3 3 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK59870.1 - 8.7e-16 58.1 1.2 7.7e-06 26.2 0.0 4.1 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 PIK59870.1 - 1.1e-15 57.3 3.4 1.4e-13 50.6 0.3 2.7 2 0 0 2 2 2 2 twin BRCT domain RTT107_BRCT_5 PF16770.5 PIK59870.1 - 7.8e-05 22.5 0.0 0.0064 16.4 0.0 3.1 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 PIK59870.1 - 0.0036 17.3 2.2 11 6.1 0.1 3.7 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 PIK59870.1 - 0.0063 16.8 2.9 0.3 11.4 0.4 3.5 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain KH_2 PF07650.17 PIK59870.1 - 0.067 13.0 3.2 0.077 12.8 0.8 2.2 2 0 0 2 2 2 0 KH domain Acp26Ab PF05777.12 PIK59870.1 - 0.067 13.8 0.2 0.36 11.5 0.1 2.2 2 0 0 2 2 2 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) HMG_box PF00505.19 PIK59871.1 - 8e-07 29.4 0.1 1.5e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box NOA36 PF06524.12 PIK59872.1 - 7.9 5.7 7.0 4.8 6.4 1.0 2.1 2 0 0 2 2 2 0 NOA36 protein Fibrinogen_C PF00147.18 PIK59873.1 - 1e-31 110.5 0.1 1.4e-31 110.0 0.1 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ErmC PF06308.11 PIK59873.1 - 1.8 9.0 7.2 0.56 10.6 0.7 3.0 3 0 0 3 3 3 0 23S rRNA methylastransferase leader peptide (ErmCL) Csm2_III-A PF03750.13 PIK59876.1 - 0.005 17.7 0.3 0.0073 17.1 0.3 1.2 1 0 0 1 1 1 1 Csm2 Type III-A ABC_membrane_3 PF13748.6 PIK59876.1 - 0.039 13.2 0.7 0.054 12.7 0.7 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region Mad3_BUB1_I PF08311.12 PIK59877.1 - 0.13 12.2 1.9 0.29 11.1 1.9 1.6 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 Methyltransf_34 PF11312.8 PIK59879.1 - 0.0036 16.6 0.1 0.063 12.5 0.1 2.1 1 1 0 1 1 1 1 Putative SAM-dependent methyltransferase Ssl1 PF04056.14 PIK59879.1 - 0.042 13.7 0.0 0.088 12.6 0.0 1.6 1 0 0 1 1 1 0 Ssl1-like NiFe_hyd_SSU_C PF14720.6 PIK59879.1 - 0.23 11.8 1.9 0.47 10.9 1.9 1.5 1 0 0 1 1 1 0 NiFe/NiFeSe hydrogenase small subunit C-terminal Fibrinogen_C PF00147.18 PIK59880.1 - 6.3e-53 179.8 7.2 8.2e-53 179.5 7.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59880.1 - 4.8e-06 26.7 6.2 1.2e-05 25.4 6.2 1.7 1 0 0 1 1 1 1 EGF domain EGF_CA PF07645.15 PIK59880.1 - 0.13 12.5 3.2 0.4 10.9 3.2 1.9 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF_2 PF07974.13 PIK59880.1 - 0.34 11.3 5.0 0.94 9.9 5.0 1.8 1 0 0 1 1 1 0 EGF-like domain FXa_inhibition PF14670.6 PIK59880.1 - 1.5 9.2 6.6 4.2 7.7 6.6 1.8 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site Fibrinogen_C PF00147.18 PIK59881.1 - 2.8e-55 187.5 11.2 6.1e-51 173.3 9.2 2.0 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59882.1 - 1.3e-39 136.3 1.9 1.6e-39 136.0 1.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK59882.1 - 0.038 14.2 11.0 0.038 14.2 11.0 1.8 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain WD40 PF00400.32 PIK59883.1 - 1.2e-24 86.1 7.5 5.9e-06 26.9 0.0 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK59883.1 - 5.3e-13 49.1 0.0 0.0074 16.6 0.0 5.0 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain SGL PF08450.12 PIK59883.1 - 0.019 14.6 0.0 0.064 12.8 0.1 2.0 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region ArfGap PF01412.18 PIK59884.1 - 1e-35 122.3 0.1 1.4e-35 121.9 0.1 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RC-P840_PscD PF10657.9 PIK59884.1 - 0.01 16.0 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction centre protein PscD DUF1539 PF07560.11 PIK59885.1 - 0.012 15.7 0.6 0.015 15.4 0.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) LTV PF04180.14 PIK59887.1 - 5.3e-13 49.5 2.2 2.4e-12 47.3 2.2 1.9 1 1 0 1 1 1 1 Low temperature viability protein LTV PF04180.14 PIK59888.1 - 1.4e-41 143.6 5.8 1.6e-41 143.3 5.8 1.0 1 0 0 1 1 1 1 Low temperature viability protein UNC-79 PF14776.6 PIK59888.1 - 0.016 14.0 1.2 0.018 13.8 1.2 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 MFS_1 PF07690.16 PIK59889.1 - 5e-46 157.3 49.1 2.9e-45 154.7 27.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PCMD PF13201.6 PIK59889.1 - 0.0079 16.0 0.2 0.016 15.0 0.2 1.4 1 0 0 1 1 1 1 Putative carbohydrate metabolism domain MFS_1 PF07690.16 PIK59890.1 - 0.0072 15.3 0.2 0.03 13.3 0.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Presenilin PF01080.17 PIK59890.1 - 0.06 12.1 0.9 0.076 11.8 0.9 1.2 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 PIK59890.1 - 0.22 10.9 10.6 0.3 10.5 10.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Fibrinogen_C PF00147.18 PIK59891.1 - 4.7e-87 291.4 24.1 9.4e-50 169.5 19.1 2.0 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain HC2 PF07382.11 PIK59892.1 - 8.3e-22 78.2 75.8 5.6e-13 49.4 49.4 2.1 2 0 0 2 2 2 2 Histone H1-like nucleoprotein HC2 Pentapeptide PF00805.22 PIK59892.1 - 1.8e-08 33.9 0.0 0.00023 20.7 0.0 2.6 2 0 0 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 PIK59892.1 - 1.6e-06 28.2 4.8 3.5e-05 23.9 1.9 2.6 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) FlpD PF02662.16 PIK59892.1 - 7 6.7 9.2 2.4 8.2 3.4 2.9 1 1 2 3 3 3 0 Methyl-viologen-reducing hydrogenase, delta subunit Fibrinogen_C PF00147.18 PIK59893.1 - 2.2e-29 102.8 5.2 1.5e-27 96.8 1.6 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK59893.1 - 4.9e-06 26.7 17.8 8.2e-06 26.0 17.8 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain EGF_CA PF07645.15 PIK59893.1 - 0.0014 18.8 13.9 0.0028 17.8 13.9 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain TILa PF12714.7 PIK59894.1 - 3.4e-09 36.5 6.4 3.4e-09 36.5 6.4 3.0 3 1 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59894.1 - 1.1e-06 28.7 28.6 8e-06 26.0 12.9 4.0 3 1 1 4 4 4 2 EGF domain cEGF PF12662.7 PIK59894.1 - 0.0012 18.7 9.7 0.018 15.0 0.2 4.2 4 1 0 4 4 4 2 Complement Clr-like EGF-like Tme5_EGF_like PF09064.10 PIK59894.1 - 0.0023 17.8 23.0 0.011 15.6 0.5 3.3 2 1 1 3 3 3 2 Thrombomodulin like fifth domain, EGF-like EGF_MSP1_1 PF12946.7 PIK59894.1 - 0.0026 17.8 10.2 0.027 14.5 6.9 3.1 4 0 0 4 4 4 2 MSP1 EGF domain 1 EGF_CA PF07645.15 PIK59894.1 - 0.0067 16.6 25.1 0.06 13.6 0.3 3.9 2 1 2 4 4 4 2 Calcium-binding EGF domain EB PF01683.18 PIK59894.1 - 0.065 13.5 7.5 0.065 13.5 7.5 3.5 2 1 1 3 3 3 0 EB module Fibrinogen_C PF00147.18 PIK59894.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain FXa_inhibition PF14670.6 PIK59894.1 - 0.14 12.4 0.5 0.14 12.4 0.5 4.0 3 1 1 4 4 4 0 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK59894.1 - 0.58 10.5 0.1 0.58 10.5 0.1 4.2 3 1 0 3 3 3 0 EGF-like domain Fibrinogen_C PF00147.18 PIK59895.1 - 3.1e-23 82.7 0.2 3.4e-23 82.6 0.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF5010_C PF18099.1 PIK59895.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 DUF5010 C-terminal domain Fibrinogen_C PF00147.18 PIK59896.1 - 2.8e-44 151.5 2.0 3.6e-44 151.2 2.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59896.1 - 0.00096 19.3 0.6 0.002 18.3 0.6 1.6 1 0 0 1 1 1 1 EGF domain cEGF PF12662.7 PIK59896.1 - 0.0077 16.1 5.0 0.017 15.1 5.0 1.6 1 0 0 1 1 1 1 Complement Clr-like EGF-like SH3_1 PF00018.28 PIK59897.1 - 0.0002 20.9 0.0 0.00048 19.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK59897.1 - 0.0093 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TPR_8 PF13181.6 PIK59898.1 - 1.5e-05 24.8 0.1 0.24 11.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK59898.1 - 1.5e-05 25.4 0.0 0.51 10.9 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK59898.1 - 2.4e-05 24.1 0.0 1.2 9.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK59898.1 - 0.00014 22.3 0.0 2 9.2 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK59898.1 - 0.00015 22.0 0.0 0.13 12.6 0.0 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK59898.1 - 0.00043 20.0 0.1 0.24 11.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK59898.1 - 0.0077 15.6 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region ANAPC3 PF12895.7 PIK59898.1 - 0.014 15.6 0.5 4.1 7.7 0.1 2.9 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ATP13 PF12921.7 PIK59898.1 - 0.07 13.0 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 Mitochondrial ATPase expression UPA PF17217.3 PIK59899.1 - 1.2e-39 135.3 0.0 2.1e-39 134.6 0.0 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 PIK59899.1 - 4.2e-27 94.4 0.1 4.2e-26 91.1 0.0 2.7 3 0 0 3 3 3 1 ZU5 domain Ig_3 PF13927.6 PIK59899.1 - 4.9e-05 23.8 5.5 6.1e-05 23.5 1.7 3.0 2 1 0 2 2 2 1 Immunoglobulin domain Death PF00531.22 PIK59899.1 - 0.0062 16.7 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 Death domain I-set PF07679.16 PIK59899.1 - 0.044 13.9 0.5 3.1 7.9 0.0 2.6 1 1 1 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK59899.1 - 0.046 14.1 3.8 6.6 7.1 2.3 3.5 2 1 0 2 2 2 0 Immunoglobulin domain TSP_1 PF00090.19 PIK59899.1 - 0.15 12.3 6.2 0.45 10.8 6.2 1.9 1 0 0 1 1 1 0 Thrombospondin type 1 domain RRM_1 PF00076.22 PIK59900.1 - 6.5e-28 96.3 0.0 2e-09 37.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK59900.1 - 0.031 14.3 0.2 11 6.1 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif NEMO PF11577.8 PIK59900.1 - 0.047 13.7 0.3 0.096 12.7 0.3 1.4 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO RA PF00788.23 PIK59901.1 - 9.5e-10 39.0 0.0 2e-09 38.0 0.0 1.5 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 PIK59901.1 - 0.00014 21.7 2.2 0.00024 20.9 2.2 1.4 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Ras_bdg_2 PF14847.6 PIK59901.1 - 0.00066 20.0 0.0 0.016 15.6 0.0 2.0 1 1 1 2 2 2 1 Ras-binding domain of Byr2 YusW PF14039.6 PIK59901.1 - 0.0037 17.8 0.3 0.023 15.2 0.0 2.1 2 1 0 2 2 2 1 YusW-like protein SHIPPO-rpt PF07004.12 PIK59902.1 - 1.7e-18 66.6 37.7 0.036 15.0 0.3 12.4 12 0 0 12 12 12 11 Sperm-tail PG-rich repeat HSP70 PF00012.20 PIK59903.1 - 9.8e-121 403.8 4.5 2.8e-120 402.3 4.5 1.6 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK59903.1 - 1e-14 54.1 0.1 2.7e-12 46.2 0.1 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 PIK59903.1 - 0.022 15.2 0.5 2 8.9 0.3 2.8 2 1 0 2 2 2 0 Cell division protein FtsA DDR PF08841.10 PIK59903.1 - 0.037 13.0 0.1 0.053 12.5 0.1 1.3 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.11 PIK59903.1 - 0.058 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 StbA protein Hydantoinase_A PF01968.18 PIK59903.1 - 0.13 11.5 1.2 0.21 10.8 0.2 1.9 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase HSP70 PF00012.20 PIK59904.1 - 4.6e-54 183.6 10.8 8.2e-52 176.2 10.8 2.0 1 1 0 1 1 1 1 Hsp70 protein Membralin PF09746.9 PIK59904.1 - 0.51 9.3 4.1 0.81 8.7 4.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein HSP70 PF00012.20 PIK59905.1 - 1.6e-10 39.8 9.6 1.8e-10 39.6 9.6 1.0 1 0 0 1 1 1 1 Hsp70 protein Z1 PF10593.9 PIK59905.1 - 0.38 10.2 3.7 0.42 10.1 3.7 1.0 1 0 0 1 1 1 0 Z1 domain DUF3813 PF12758.7 PIK59905.1 - 0.38 11.1 4.5 0.62 10.4 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3813) TarH PF02203.15 PIK59905.1 - 0.48 10.3 2.5 0.52 10.2 2.5 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue HSP70 PF00012.20 PIK59906.1 - 5.7e-132 440.9 0.2 6.9e-132 440.6 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 PIK59906.1 - 1e-13 50.9 0.0 1.3e-08 34.1 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 PIK59906.1 - 0.00037 20.3 0.0 0.00059 19.6 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 PIK59906.1 - 0.0052 15.8 0.0 0.16 10.9 0.0 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain DUF1464 PF07318.12 PIK59906.1 - 0.021 14.0 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) PilM_2 PF11104.8 PIK59906.1 - 0.022 13.8 0.0 2.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Raco_middle PF17651.1 PIK59906.1 - 0.065 12.9 0.0 0.61 9.8 0.0 2.2 1 1 1 2 2 2 0 RACo middle region MetOD2 PF18548.1 PIK59906.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Metanogen output domain 2 Pkinase PF00069.25 PIK59907.1 - 1.2e-11 44.5 0.2 1.2e-11 44.4 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59907.1 - 6.4e-06 25.6 0.1 6.8e-06 25.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK59908.1 - 1e-35 123.4 0.0 1.1e-35 123.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK59908.1 - 3.6e-13 49.4 0.0 4.1e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DEC-1_N PF04625.13 PIK59910.1 - 0.0074 15.4 1.9 0.009 15.1 1.9 1.2 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region CUTL PF16557.5 PIK59911.1 - 0.094 12.9 0.1 0.3 11.3 0.1 1.8 1 0 0 1 1 1 0 CUT1-like DNA-binding domain of SATB RRM_1 PF00076.22 PIK59912.1 - 9.2e-16 57.4 0.1 8.8e-11 41.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 PIK59912.1 - 0.0022 18.0 0.0 0.09 12.8 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif SMN PF06003.12 PIK59913.1 - 6.1 6.0 12.8 2.8 7.1 10.7 1.5 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) C2 PF00168.30 PIK59915.1 - 2e-10 40.9 0.0 2.4e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 C2 domain BEN PF10523.9 PIK59916.1 - 2.2e-09 37.4 0.0 4.5e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 BEN domain APG6_N PF17675.1 PIK59916.1 - 0.13 12.8 6.0 0.32 11.5 6.0 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Pox_RNA_Pol_19 PF05320.12 PIK59916.1 - 0.16 11.9 1.9 0.26 11.2 1.9 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit ANAPC4_WD40 PF12894.7 PIK59917.1 - 0.00019 21.7 0.1 0.0058 16.9 0.1 2.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK59917.1 - 0.0042 17.9 0.2 0.68 10.9 0.0 2.8 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40_3 PF15911.5 PIK59918.1 - 5.9e-26 90.2 0.9 9.3e-26 89.6 0.1 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Clathrin PF00637.20 PIK59918.1 - 3.3e-08 33.5 6.8 0.0064 16.4 0.1 4.3 3 1 2 5 5 5 2 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 PIK59918.1 - 0.00072 18.7 4.3 0.14 11.1 0.2 3.0 3 0 0 3 3 3 2 Coatomer WD associated region Nic96 PF04097.14 PIK59918.1 - 0.0025 16.3 1.5 0.022 13.2 0.4 2.1 1 1 1 2 2 2 1 Nup93/Nic96 TPR_14 PF13428.6 PIK59918.1 - 0.0026 18.4 0.3 1.3 10.0 0.4 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK59918.1 - 0.0073 16.4 4.0 3 8.3 0.4 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 PIK59918.1 - 0.015 14.7 1.6 0.039 13.4 1.5 1.7 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 PIK59918.1 - 0.023 14.7 0.7 34 4.8 0.1 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK59918.1 - 0.046 13.9 7.7 1.3 9.3 0.5 5.2 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK59918.1 - 5.7 6.9 11.8 15 5.6 2.0 5.3 7 0 0 7 7 7 0 Tetratricopeptide repeat DZR PF12773.7 PIK59919.1 - 0.00059 19.8 8.7 0.0074 16.3 6.6 2.4 2 0 0 2 2 2 1 Double zinc ribbon zf-ribbon_3 PF13248.6 PIK59919.1 - 0.0036 16.7 7.6 0.25 10.8 1.8 3.2 3 0 0 3 3 3 2 zinc-ribbon domain zinc_ribbon_2 PF13240.6 PIK59919.1 - 0.022 14.5 7.7 1.2 8.9 2.8 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf-Di19 PF05605.12 PIK59919.1 - 0.025 14.9 17.0 0.76 10.1 8.3 3.7 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_4 PF14570.6 PIK59919.1 - 0.041 13.7 10.8 0.2 11.5 6.4 2.6 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_9 PF14369.6 PIK59919.1 - 0.65 10.3 12.7 8.6 6.7 3.8 3.6 3 1 0 3 3 3 0 zinc-ribbon Prok-RING_1 PF14446.6 PIK59919.1 - 2.6 8.1 12.2 17 5.4 2.0 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-4CXXC_R1 PF10497.9 PIK59919.1 - 3 8.1 7.9 4 7.7 6.5 2.0 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf_UBZ PF18439.1 PIK59919.1 - 5.9 6.6 12.0 3.1 7.5 1.8 3.7 3 1 1 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-LITAF-like PF10601.9 PIK59919.1 - 7.8 6.8 12.8 1.2 9.4 2.1 3.1 1 1 2 3 3 3 0 LITAF-like zinc ribbon domain HypA PF01155.19 PIK59919.1 - 9.4 6.3 9.2 1.8e+02 2.2 9.0 2.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SOAR PF16533.5 PIK59920.1 - 7.6e-36 122.1 18.0 3.6e-35 120.0 3.2 2.8 2 1 0 2 2 2 2 STIM1 Orai1-activating region SAM_2 PF07647.17 PIK59920.1 - 1.3e-10 41.2 0.0 4.2e-10 39.6 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 PIK59920.1 - 4.3e-09 36.7 0.0 1.3e-08 35.1 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Halogen_Hydrol PF10112.9 PIK59920.1 - 0.08 13.0 0.3 0.08 13.0 0.3 3.0 3 1 1 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein SAM_Ste50p PF09235.10 PIK59920.1 - 0.13 12.5 0.1 0.57 10.5 0.0 2.1 2 0 0 2 2 2 0 Ste50p, sterile alpha motif COG5 PF10392.9 PIK59920.1 - 1.7 8.8 6.4 0.39 10.9 0.3 2.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 PI3K_P85_iSH2 PF16454.5 PIK59920.1 - 2.7 7.6 19.6 0.44 10.1 7.1 3.4 3 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Cadherin PF00028.17 PIK59921.1 - 3.9e-92 302.9 1.9 1.2e-16 61.0 0.0 7.3 7 0 0 7 7 7 7 Cadherin domain Cadherin_2 PF08266.12 PIK59921.1 - 2.3e-08 33.7 0.0 3.5e-05 23.5 0.0 4.4 4 0 0 4 4 4 1 Cadherin-like PAG PF15347.6 PIK59921.1 - 0.0022 17.1 0.0 0.0049 15.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched DnaJ PF00226.31 PIK59922.1 - 1.1e-25 89.6 3.0 2.4e-25 88.5 3.0 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 PIK59922.1 - 1.2e-25 90.4 0.0 1.9e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 PIK59922.1 - 1.5e-09 38.0 16.5 1.5e-09 38.0 16.5 1.9 2 0 0 2 2 2 1 DnaJ central domain KAsynt_C_assoc PF16197.5 PIK59922.1 - 0.0054 17.2 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Anti-TRAP PF15777.5 PIK59922.1 - 0.029 14.3 1.0 0.029 14.3 1.0 3.4 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein YtxH PF12732.7 PIK59922.1 - 3.8 8.1 5.0 52 4.5 0.1 2.4 2 0 0 2 2 2 0 YtxH-like protein 7tm_1 PF00001.21 PIK59923.1 - 3.1e-15 56.2 3.3 4.4e-15 55.7 3.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK59923.1 - 0.00022 20.7 3.7 0.0004 19.9 3.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DNA_pol_A_exo1 PF01612.20 PIK59924.1 - 3.5e-14 52.9 0.0 5.6e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease CitMHS PF03600.16 PIK59925.1 - 2.5e-22 79.4 7.3 3.5e-22 79.0 7.3 1.2 1 0 0 1 1 1 1 Citrate transporter Na_sulph_symp PF00939.19 PIK59925.1 - 8.5e-14 51.4 6.8 1.1e-13 51.1 6.8 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CbiQ PF02361.16 PIK59925.1 - 0.058 13.0 7.4 0.07 12.7 7.4 1.1 1 0 0 1 1 1 0 Cobalt transport protein SPC25 PF06703.11 PIK59925.1 - 0.19 11.5 1.6 0.17 11.6 0.4 1.5 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Keratin_assoc PF09775.9 PIK59925.1 - 1.6 8.4 5.1 36 4.0 5.3 2.1 1 1 0 1 1 1 0 Keratinocyte-associated protein 2 CitMHS PF03600.16 PIK59926.1 - 1.9e-30 106.1 8.1 1.9e-30 106.1 8.1 1.4 2 0 0 2 2 2 1 Citrate transporter ArsB PF02040.15 PIK59926.1 - 1.3e-06 28.1 9.2 2e-06 27.4 9.2 1.2 1 0 0 1 1 1 1 Arsenical pump membrane protein DctM PF06808.12 PIK59926.1 - 5.8e-06 25.4 6.4 5.8e-06 25.4 6.4 1.4 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component PDR_CDR PF06422.12 PIK59926.1 - 0.35 10.8 0.1 0.35 10.8 0.1 2.5 3 0 0 3 3 3 0 CDR ABC transporter Cyclin_N PF00134.23 PIK59927.1 - 8.9e-14 51.3 0.2 1.6e-13 50.5 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 PIK59927.1 - 0.066 13.3 2.2 0.16 12.1 2.0 1.8 1 1 0 1 1 1 0 Cyclin, C-terminal domain Phage_int_SAM_4 PF13495.6 PIK59928.1 - 0.0011 19.4 0.1 0.0021 18.5 0.1 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK59928.1 - 0.0025 18.1 0.2 0.0068 16.7 0.2 1.7 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.22 PIK59928.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 Phage integrase family MPC PF03650.13 PIK59929.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial pyruvate carriers Scramblase PF03803.15 PIK59930.1 - 0.0019 17.5 0.0 0.2 10.9 0.0 2.1 1 1 0 1 1 1 1 Scramblase fn3 PF00041.21 PIK59933.1 - 3.2e-14 53.1 2.3 1.9e-08 34.6 0.2 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK59933.1 - 0.0021 18.6 0.5 0.55 10.8 0.1 2.4 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 PIK59934.1 - 8.4e-20 70.9 2.8 2.1e-14 53.6 1.0 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK59934.1 - 2.2e-07 31.3 1.4 4.2e-05 24.1 0.6 2.2 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Uroplakin_II PF07353.12 PIK59934.1 - 0.086 12.3 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Uroplakin II CCDC84 PF14968.6 PIK59935.1 - 2.5e-52 178.7 12.3 1e-51 176.6 12.3 1.7 1 1 0 1 1 1 1 Coiled coil protein 84 RE_HaeIII PF09556.10 PIK59935.1 - 0.058 12.5 2.1 0.096 11.7 2.1 1.3 1 0 0 1 1 1 0 HaeIII restriction endonuclease Ion_trans PF00520.31 PIK59936.1 - 5.2e-06 25.9 2.5 7.5e-06 25.3 2.5 1.2 1 0 0 1 1 1 1 Ion transport protein Bac_rhamnosid6H PF17389.2 PIK59936.1 - 0.042 13.1 0.7 3.2 6.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Syntaxin_2 PF14523.6 PIK59936.1 - 0.073 13.4 1.6 1.3 9.4 0.1 2.4 2 1 0 2 2 2 0 Syntaxin-like protein eIF-5_eIF-2B PF01873.17 PIK59936.1 - 0.1 12.4 0.2 0.2 11.5 0.2 1.4 1 0 0 1 1 1 0 Domain found in IF2B/IF5 RNase_H2-Ydr279 PF09468.10 PIK59936.1 - 0.14 12.4 0.2 0.24 11.6 0.2 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain 7tm_7 PF08395.12 PIK59937.1 - 2e-10 40.4 28.1 2.5e-10 40.1 28.1 1.0 1 0 0 1 1 1 1 7tm Chemosensory receptor CarboxypepD_reg PF13620.6 PIK59938.1 - 2.2e-08 34.2 0.1 2.9e-06 27.5 0.0 3.0 2 2 0 2 2 2 1 Carboxypeptidase regulatory-like domain fn3 PF00041.21 PIK59938.1 - 0.11 12.8 0.0 8.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Fibronectin type III domain Big_6 PF17936.1 PIK59938.1 - 0.11 12.7 0.1 0.31 11.4 0.1 1.9 1 0 0 1 1 1 0 Bacterial Ig domain 2OG-FeII_Oxy_2 PF13532.6 PIK59938.1 - 0.16 12.2 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily CarboxypepD_reg PF13620.6 PIK59939.1 - 4.1e-27 94.3 14.6 1.1e-06 28.8 0.1 7.3 8 1 0 8 8 7 5 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 PIK59939.1 - 1.2e-18 66.9 9.5 1.4e-05 25.0 0.2 6.1 6 0 0 6 6 6 4 CarboxypepD_reg-like domain DUF2012 PF09430.10 PIK59939.1 - 1.4e-16 60.8 0.2 8.3e-05 22.7 0.0 6.4 4 1 0 6 6 6 3 Protein of unknown function (DUF2012) SdrD_B PF17210.3 PIK59939.1 - 1.1e-14 54.6 3.7 0.024 14.9 0.0 6.5 6 2 0 6 6 6 5 SdrD B-like domain fn3_3 PF14686.6 PIK59939.1 - 4.2e-13 48.9 2.3 0.12 12.2 0.0 6.8 7 1 1 8 8 8 3 Polysaccharide lyase family 4, domain II SpaA PF17802.1 PIK59939.1 - 1.4e-11 44.6 0.4 0.011 16.0 0.0 5.8 6 0 0 6 6 6 3 Prealbumin-like fold domain Y_Y_Y PF07495.13 PIK59939.1 - 0.0027 17.6 1.4 19 5.3 0.0 5.3 7 0 0 7 7 7 0 Y_Y_Y domain DUF1416 PF07210.12 PIK59939.1 - 0.0048 16.8 0.1 26 4.8 0.1 4.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1416) MG4 PF17789.1 PIK59939.1 - 0.034 14.3 5.8 2.3 8.4 0.0 4.9 5 1 0 5 5 5 0 Macroglobulin domain MG4 Dioxygenase_C PF00775.21 PIK59939.1 - 0.11 11.9 0.0 9 5.7 0.0 3.7 5 0 0 5 5 5 0 Dioxygenase MetallophosN PF16371.5 PIK59939.1 - 0.26 11.6 6.1 5.6 7.3 0.2 5.3 6 0 0 6 6 6 0 N terminal of Calcineurin-like phosphoesterase Big_1 PF02369.16 PIK59939.1 - 0.62 10.1 14.8 0.13 12.3 0.6 4.6 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 1) Ig_3 PF13927.6 PIK59940.1 - 7.5e-08 32.9 3.4 0.12 13.0 0.1 4.5 4 1 1 5 5 5 3 Immunoglobulin domain V-set PF07686.17 PIK59940.1 - 2.4e-05 24.5 0.6 0.0078 16.4 0.0 3.2 4 0 0 4 4 4 1 Immunoglobulin V-set domain I-set PF07679.16 PIK59940.1 - 2.8e-05 24.1 1.0 0.18 11.9 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain NACHT PF05729.12 PIK59940.1 - 0.0011 18.9 0.0 0.0032 17.4 0.0 1.8 1 0 0 1 1 1 1 NACHT domain C2-set_2 PF08205.12 PIK59940.1 - 0.021 14.9 0.2 0.074 13.1 0.2 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK59940.1 - 0.022 14.9 0.2 2.2 8.5 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin domain ResIII PF04851.15 PIK59940.1 - 0.045 13.8 0.2 1.2 9.2 0.0 2.4 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ATPase PF06745.13 PIK59940.1 - 0.078 12.3 1.8 8.3 5.7 0.0 3.1 3 0 0 3 3 3 0 KaiC Hpr_kinase_C PF07475.12 PIK59940.1 - 0.14 11.7 0.3 0.99 8.9 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 PIK59940.1 - 0.16 12.4 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RVT_1 PF00078.27 PIK59941.1 - 9e-33 113.6 0.3 6.4e-32 110.9 0.2 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Fibrinogen_C PF00147.18 PIK59942.1 - 4.2e-37 128.1 2.0 6.4e-37 127.5 2.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59942.1 - 7e-07 29.1 5.5 7.8e-07 29.0 1.2 2.8 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59942.1 - 9.4e-05 22.5 8.0 0.00031 20.9 6.7 2.5 1 1 1 2 2 2 1 EGF domain COLFI PF01410.18 PIK59942.1 - 0.0038 16.5 0.8 0.0049 16.2 0.4 1.4 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain IgGFc_binding PF17517.2 PIK59943.1 - 7.8e-19 68.0 3.3 7.8e-19 68.0 3.3 1.7 2 0 0 2 2 2 1 IgGFc binding protein Fibrinogen_C PF00147.18 PIK59944.1 - 3.5e-62 210.1 3.6 4.7e-62 209.7 3.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59945.1 - 2.1e-61 207.5 5.6 2.6e-61 207.2 5.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59946.1 - 5.6e-38 130.9 10.0 5e-36 124.6 5.5 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK59947.1 - 3.6e-14 52.8 0.0 5.4e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Polysacc_deac_2 PF04748.13 PIK59947.1 - 0.055 12.6 0.0 0.094 11.9 0.0 1.3 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase FYDLN_acid PF09538.10 PIK59947.1 - 0.24 12.1 2.2 0.43 11.3 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Fibrinogen_C PF00147.18 PIK59948.1 - 2.8e-30 105.8 4.7 5.2e-23 82.0 0.9 2.0 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Pox_C7_F8A PF03287.14 PIK59948.1 - 0.012 15.5 0.4 0.016 15.2 0.4 1.1 1 0 0 1 1 1 0 Poxvirus C7/F8A protein GD_N PF16030.5 PIK59948.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Serine protease gd N-terminus Fibrinogen_C PF00147.18 PIK59949.1 - 3.3e-35 121.9 0.7 4.1e-35 121.6 0.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK59950.1 - 1.8e-11 44.3 0.1 3.7e-11 43.3 0.1 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59950.1 - 1.4e-09 38.0 38.7 0.0001 22.4 12.8 4.0 2 2 2 4 4 4 2 EGF domain TILa PF12714.7 PIK59950.1 - 1.1e-05 25.3 23.0 0.011 15.6 7.4 2.6 2 0 0 2 2 2 2 TILa domain EGF_MSP1_1 PF12946.7 PIK59950.1 - 0.00015 21.8 21.0 0.00031 20.7 5.5 3.1 2 1 1 3 3 3 2 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK59950.1 - 0.00019 21.7 26.9 0.0075 16.6 8.0 3.2 2 1 0 2 2 2 2 EGF-like domain Fibrinogen_C PF00147.18 PIK59951.1 - 1.8e-26 93.3 1.8 2e-26 93.2 1.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4218 PF13960.6 PIK59952.1 - 0.025 14.2 0.2 0.049 13.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) rve PF00665.26 PIK59953.1 - 1.1e-18 67.6 0.0 1.7e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Fibrinogen_C PF00147.18 PIK59955.1 - 1.7e-86 289.6 17.4 7.4e-51 173.1 11.3 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59955.1 - 3.4e-12 46.4 72.2 5.6e-05 23.2 11.9 7.2 4 3 3 7 7 7 3 EGF domain TILa PF12714.7 PIK59955.1 - 2e-09 37.2 29.8 5.2e-05 23.1 5.9 6.6 4 2 2 6 6 6 3 TILa domain EGF_MSP1_1 PF12946.7 PIK59955.1 - 1.3e-05 25.1 41.5 0.00081 19.4 5.5 5.3 4 0 0 4 4 4 3 MSP1 EGF domain 1 TIL PF01826.17 PIK59955.1 - 0.0028 17.9 13.9 0.0028 17.9 13.9 7.2 3 1 2 5 5 5 1 Trypsin Inhibitor like cysteine rich domain Caprin-1_C PF12287.8 PIK59955.1 - 0.086 13.0 4.4 0.65 10.1 0.2 2.4 1 1 1 2 2 2 0 Cytoplasmic activation/proliferation-associated protein-1 C term Fibrinogen_C PF00147.18 PIK59956.1 - 1.2e-47 162.6 4.8 1.1e-45 156.1 3.5 2.5 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59956.1 - 2.5e-09 36.9 15.6 9.8e-06 25.4 4.5 4.1 2 1 2 4 4 4 2 TILa domain EGF_3 PF12947.7 PIK59956.1 - 1.8e-07 31.2 31.2 3.6e-06 27.1 8.5 5.4 5 1 1 6 6 6 2 EGF domain EGF_MSP1_1 PF12946.7 PIK59956.1 - 0.0033 17.4 18.2 0.013 15.5 6.7 4.2 5 0 0 5 5 5 2 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK59956.1 - 0.0085 16.4 8.4 0.0085 16.4 8.4 5.2 3 2 0 3 3 3 2 EGF-like domain TIL PF01826.17 PIK59956.1 - 0.0095 16.2 13.0 0.0095 16.2 13.0 4.2 3 2 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK59957.1 - 3.1e-46 157.9 3.1 1.3e-34 120.0 0.6 2.3 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59957.1 - 2.2e-15 56.3 31.3 3e-05 23.9 7.0 3.8 3 0 0 3 3 3 3 TILa domain EGF_3 PF12947.7 PIK59957.1 - 1.1e-11 44.8 64.7 0.00048 20.3 13.6 6.0 3 3 3 6 6 6 3 EGF domain EGF_MSP1_1 PF12946.7 PIK59957.1 - 4.2e-11 42.7 35.7 0.0016 18.5 5.8 4.4 3 0 0 3 3 3 3 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK59957.1 - 3.7e-08 33.6 41.0 0.018 15.4 6.5 4.5 3 0 0 3 3 3 3 EGF-like domain Caprin-1_C PF12287.8 PIK59957.1 - 0.09 12.9 5.7 8.2 6.5 0.4 3.2 1 1 2 3 3 3 0 Cytoplasmic activation/proliferation-associated protein-1 C term Fibrinogen_C PF00147.18 PIK59959.1 - 1.1e-40 139.8 5.5 1.4e-34 119.8 1.1 2.2 1 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK59959.1 - 7.4e-06 25.8 6.0 7.4e-06 25.8 6.0 3.3 1 1 2 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK59959.1 - 9.2e-06 25.8 9.1 9.2e-06 25.8 9.1 3.8 3 1 1 4 4 4 1 EGF domain TIL PF01826.17 PIK59959.1 - 0.0031 17.7 13.9 0.0031 17.7 13.9 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain EGF_2 PF07974.13 PIK59959.1 - 0.044 14.2 9.3 0.044 14.2 9.3 4.1 2 2 0 2 2 2 0 EGF-like domain DUF1758 PF05585.12 PIK59960.1 - 1.5e-06 28.1 0.0 4.4e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 PIK59960.1 - 0.00027 21.5 0.1 0.00094 19.8 0.0 2.0 2 1 1 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK59960.1 - 0.018 15.6 0.0 0.079 13.5 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Pneumo_att_G PF05539.11 PIK59960.1 - 1.3 8.6 7.6 1.7 8.2 7.6 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Fibrinogen_C PF00147.18 PIK59961.1 - 3.2e-90 301.8 22.3 4.1e-53 180.4 11.4 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK59961.1 - 2.1e-06 27.8 9.3 2.1e-06 27.8 9.3 4.1 2 1 1 3 3 3 1 EGF domain TILa PF12714.7 PIK59961.1 - 7.4e-06 25.8 6.6 7.4e-06 25.8 6.6 4.2 2 1 2 4 4 4 1 TILa domain TIL PF01826.17 PIK59961.1 - 0.0017 18.6 13.4 0.0017 18.6 13.4 3.9 4 1 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain YaiA PF16362.5 PIK59961.1 - 0.18 11.9 0.0 0.77 9.9 0.0 2.1 2 0 0 2 2 2 0 YaiA protein EGF_MSP1_1 PF12946.7 PIK59961.1 - 0.87 9.7 16.8 0.048 13.7 5.5 3.1 2 0 0 2 2 2 0 MSP1 EGF domain 1 EGF_2 PF07974.13 PIK59961.1 - 3.9 7.9 26.9 0.27 11.6 11.1 4.3 2 1 0 2 2 2 0 EGF-like domain NFACT-R_1 PF05670.13 PIK59962.1 - 5.4e-40 136.4 0.3 1e-39 135.5 0.0 1.5 2 0 0 2 2 2 1 NFACT protein RNA binding domain AAA_11 PF13086.6 PIK59962.1 - 0.79 9.5 11.8 1.1 9.0 11.8 1.1 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.16 PIK59962.1 - 3.8 7.0 10.7 5.7 6.4 10.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 COX5B PF01215.19 PIK59963.1 - 1.2e-17 63.8 0.1 1.5e-17 63.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Pkinase_Tyr PF07714.17 PIK59964.1 - 5e-91 304.6 0.0 9.8e-91 303.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.13 PIK59964.1 - 9.4e-52 174.5 5.5 9.4e-52 174.5 5.5 1.8 2 0 0 2 2 2 1 Focal adhesion targeting region Pkinase PF00069.25 PIK59964.1 - 1.8e-45 155.4 0.0 4.6e-45 154.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain FERM_N_2 PF18038.1 PIK59964.1 - 1.9e-22 79.9 1.7 3.8e-22 78.9 0.3 2.2 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 PIK59964.1 - 2e-11 44.3 0.7 1.4e-10 41.6 0.3 2.3 2 0 0 2 2 2 1 FERM central domain Haspin_kinase PF12330.8 PIK59964.1 - 0.001 18.1 0.1 0.0031 16.5 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain FERM_F2 PF18377.1 PIK59964.1 - 0.0011 19.0 0.4 0.0032 17.4 0.4 1.8 1 0 0 1 1 1 1 FERM F2 acyl-CoA binding protein-like domain Kinase-like PF14531.6 PIK59964.1 - 0.0035 16.7 0.0 0.0066 15.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Abi_2 PF07751.11 PIK59964.1 - 0.014 15.7 0.3 0.091 13.0 0.0 2.5 2 1 0 2 2 2 0 Abi-like protein Pkinase_Tyr PF07714.17 PIK59965.1 - 1.2e-91 306.6 0.0 1.6e-91 306.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK59965.1 - 2.9e-46 158.0 0.0 4.1e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK59965.1 - 4.2e-17 62.0 0.0 9.5e-17 60.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK59965.1 - 1.8e-15 56.2 0.3 6.2e-15 54.5 0.2 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK59965.1 - 9.8e-10 38.1 0.2 2.9e-09 36.6 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK59965.1 - 3e-08 33.2 0.0 8.5e-08 31.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Haspin_kinase PF12330.8 PIK59965.1 - 4.2e-05 22.7 0.4 9.6e-05 21.5 0.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 PIK59965.1 - 0.034 13.8 0.1 0.07 12.7 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK59965.1 - 0.078 12.3 0.3 0.22 10.9 0.3 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF727 PF05303.12 PIK59965.1 - 0.15 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF727) APH PF01636.23 PIK59965.1 - 0.19 11.6 0.1 0.43 10.5 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family zf-B_box PF00643.24 PIK59966.1 - 4.2e-10 39.6 8.3 7.2e-10 38.9 8.3 1.4 1 0 0 1 1 1 1 B-box zinc finger Phage_Mu_Gam PF07352.12 PIK59966.1 - 0.00034 20.5 2.2 0.00049 20.0 1.5 1.6 1 1 0 1 1 1 1 Bacteriophage Mu Gam like protein APG17 PF04108.12 PIK59966.1 - 0.0009 18.5 4.9 0.0011 18.1 4.9 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 ApoLp-III PF07464.11 PIK59966.1 - 0.0025 17.9 6.8 0.0033 17.5 6.8 1.1 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Dermcidin PF15291.6 PIK59966.1 - 0.018 15.6 0.4 0.12 12.9 0.1 2.0 1 1 1 2 2 2 0 Dermcidin, antibiotic peptide SHE3 PF17078.5 PIK59966.1 - 0.026 14.2 4.2 0.035 13.8 4.2 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Prominin PF05478.11 PIK59966.1 - 0.029 12.3 5.9 0.035 12.1 5.9 1.0 1 0 0 1 1 1 0 Prominin GvpL_GvpF PF06386.11 PIK59966.1 - 0.038 13.9 4.5 0.053 13.5 4.5 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF3810 PF12725.7 PIK59966.1 - 0.054 12.8 0.6 0.069 12.5 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) AAA_lid_10 PF17872.1 PIK59966.1 - 0.054 13.6 1.4 0.094 12.9 1.4 1.5 1 0 0 1 1 1 0 AAA lid domain YtxH PF12732.7 PIK59966.1 - 0.059 13.9 3.3 0.41 11.2 3.3 2.1 1 1 0 1 1 1 0 YtxH-like protein DUF885 PF05960.11 PIK59966.1 - 0.16 11.6 2.2 0.18 11.4 2.2 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DegS PF05384.11 PIK59966.1 - 0.19 11.2 7.5 0.066 12.7 2.6 2.4 1 1 2 3 3 3 0 Sensor protein DegS DUF1664 PF07889.12 PIK59966.1 - 0.2 11.7 5.6 4.9 7.2 5.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) OmpH PF03938.14 PIK59966.1 - 0.22 11.9 6.6 0.29 11.5 6.6 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATP-synt_B PF00430.18 PIK59966.1 - 0.29 11.2 9.9 1.6 8.8 8.5 2.2 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) FYVE PF01363.21 PIK59966.1 - 0.32 11.2 7.7 2.7 8.2 7.7 2.2 1 1 0 1 1 1 0 FYVE zinc finger DUF16 PF01519.16 PIK59966.1 - 0.34 11.4 7.3 0.11 13.0 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 C1_4 PF07975.12 PIK59966.1 - 0.5 10.6 8.4 0.43 10.9 6.1 2.0 2 0 0 2 2 2 0 TFIIH C1-like domain YkyA PF10368.9 PIK59966.1 - 0.61 9.7 8.1 47 3.6 0.8 1.9 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF883 PF05957.13 PIK59966.1 - 0.65 10.6 5.0 0.52 10.9 1.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) LMBR1 PF04791.16 PIK59966.1 - 1.6 7.5 3.9 1.8 7.4 3.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein COG2 PF06148.11 PIK59966.1 - 4.7 7.3 7.2 51 4.0 7.2 2.1 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 PIK59966.1 - 5.3 6.2 9.2 2.9 7.1 5.8 1.8 1 1 0 2 2 2 0 TMPIT-like protein zf-B_box PF00643.24 PIK59967.1 - 1.6e-10 41.0 11.1 3.3e-10 40.0 11.1 1.5 1 0 0 1 1 1 1 B-box zinc finger PhageMin_Tail PF10145.9 PIK59967.1 - 0.048 13.5 0.1 0.079 12.8 0.1 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein DUF763 PF05559.11 PIK59967.1 - 0.086 12.0 1.7 0.1 11.8 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF763) DUF4294 PF14127.6 PIK59967.1 - 0.098 12.6 3.9 0.062 13.2 1.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4294) STAT_alpha PF01017.20 PIK59967.1 - 0.19 11.6 6.9 0.075 12.9 3.8 1.8 1 1 0 1 1 1 0 STAT protein, all-alpha domain DUF948 PF06103.11 PIK59967.1 - 1.4 9.2 3.8 20 5.5 0.2 2.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Enkurin PF13864.6 PIK59967.1 - 3.9 8.0 9.6 0.58 10.6 4.8 2.1 2 1 1 3 3 3 0 Calmodulin-binding zf-B_box PF00643.24 PIK59968.1 - 2.5e-11 43.5 25.8 7.3e-11 42.0 7.7 2.4 2 0 0 2 2 2 2 B-box zinc finger DUF4164 PF13747.6 PIK59968.1 - 7.4e-06 26.2 2.6 1.8e-05 24.9 2.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) Baculo_PEP_C PF04513.12 PIK59968.1 - 0.0045 17.0 5.9 0.0051 16.9 4.5 1.8 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus UvrD_C PF13361.6 PIK59968.1 - 0.017 14.5 3.5 0.022 14.2 3.5 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain CortBP2 PF09727.9 PIK59968.1 - 0.019 14.9 5.1 0.031 14.2 5.1 1.4 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF2894 PF11445.8 PIK59968.1 - 0.028 14.9 0.5 0.039 14.4 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF4407 PF14362.6 PIK59968.1 - 0.041 13.2 4.8 0.051 12.9 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 4HB_MCP_1 PF12729.7 PIK59968.1 - 0.048 13.2 8.0 0.07 12.7 8.0 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction APG17 PF04108.12 PIK59968.1 - 0.054 12.6 9.2 0.088 11.9 9.2 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 SOGA PF11365.8 PIK59968.1 - 0.1 13.7 2.3 0.15 13.2 0.8 2.0 1 1 1 2 2 2 0 Protein SOGA DNA_photolyase PF00875.18 PIK59968.1 - 0.13 12.2 1.1 0.29 11.1 1.0 1.6 1 1 0 1 1 1 0 DNA photolyase DUF1664 PF07889.12 PIK59968.1 - 0.25 11.4 9.8 0.17 11.9 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) UPF0449 PF15136.6 PIK59968.1 - 0.8 10.2 7.8 0.47 11.0 5.0 2.1 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 JIP_LZII PF16471.5 PIK59968.1 - 1.2 9.4 6.2 9.1 6.5 0.2 3.0 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II MeaB PF03308.16 PIK59968.1 - 1.4 7.8 5.4 1.8 7.5 5.4 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF743 PF05332.11 PIK59968.1 - 2.2 8.3 5.8 1.6 8.8 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF743) IBR PF01485.21 PIK59968.1 - 3.1 8.1 20.8 3.5 7.9 4.9 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-CCHC PF00098.23 PIK59969.1 - 0.75 10.0 7.1 1.6 9.0 7.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-B_box PF00643.24 PIK59971.1 - 3.2e-11 43.2 31.6 3.5e-11 43.1 7.1 2.7 3 0 0 3 3 3 2 B-box zinc finger DUF4164 PF13747.6 PIK59971.1 - 0.0027 18.0 2.9 0.0041 17.4 2.0 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4164) C1_4 PF07975.12 PIK59971.1 - 0.033 14.4 22.7 0.13 12.5 3.0 3.6 3 0 0 3 3 3 0 TFIIH C1-like domain DUF4407 PF14362.6 PIK59971.1 - 0.29 10.4 3.4 0.35 10.2 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 PIK59971.1 - 3.7 7.8 9.9 2.9 8.2 7.6 1.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 PIK59971.1 - 4.8 7.2 7.7 4.4 7.4 5.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) rve PF00665.26 PIK59972.1 - 0.00014 22.1 0.0 0.0002 21.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-B_box PF00643.24 PIK59973.1 - 7.4e-10 38.8 20.7 1.2e-09 38.1 6.0 3.5 4 0 0 4 4 4 2 B-box zinc finger zf-C3HC4_3 PF13920.6 PIK59973.1 - 3.8e-08 33.0 5.6 3.8e-08 33.0 5.6 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK59973.1 - 9.7e-08 31.9 8.0 9.7e-08 31.9 8.0 2.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 PIK59973.1 - 1.1e-07 31.6 10.4 1.1e-07 31.6 10.4 3.2 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK59973.1 - 6.6e-07 29.1 9.4 6.6e-07 29.1 9.4 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK59973.1 - 1.6e-06 27.9 7.9 1.6e-06 27.9 7.9 3.8 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK59973.1 - 2.8e-06 27.4 11.7 2.8e-06 27.4 11.7 3.5 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 PIK59973.1 - 6e-06 26.5 8.6 6e-06 26.5 8.6 3.6 3 0 0 3 3 2 1 Ring finger domain DUF4164 PF13747.6 PIK59973.1 - 9.7e-05 22.6 2.7 0.0002 21.6 2.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) Prok-RING_4 PF14447.6 PIK59973.1 - 9.8e-05 22.1 6.5 9.8e-05 22.1 6.5 3.5 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 APG17 PF04108.12 PIK59973.1 - 0.00012 21.3 1.8 0.00019 20.7 1.8 1.3 1 0 0 1 1 1 1 Autophagy protein Apg17 Baculo_PEP_C PF04513.12 PIK59973.1 - 0.0002 21.4 0.2 0.00034 20.7 0.2 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_Mu_Gam PF07352.12 PIK59973.1 - 0.032 14.2 4.7 0.077 12.9 4.7 1.7 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein CortBP2 PF09727.9 PIK59973.1 - 0.055 13.4 4.6 0.1 12.5 4.6 1.4 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF5082 PF16888.5 PIK59973.1 - 0.12 12.7 6.0 0.26 11.6 5.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF465 PF04325.13 PIK59973.1 - 0.23 11.5 4.8 0.59 10.2 4.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF465) DUF4407 PF14362.6 PIK59973.1 - 0.24 10.7 3.8 0.33 10.2 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 PIK59973.1 - 0.32 11.0 4.6 1 9.4 4.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) OTT_1508_deam PF14441.6 PIK59973.1 - 0.33 11.0 8.1 3.6 7.7 1.1 2.9 2 0 0 2 2 2 0 OTT_1508-like deaminase DUF743 PF05332.11 PIK59973.1 - 1.2 9.2 3.5 4.8 7.3 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF743) zf-B_box PF00643.24 PIK59974.1 - 4.5e-10 39.5 6.7 4.5e-10 39.5 6.7 1.9 2 0 0 2 2 2 1 B-box zinc finger DUF4164 PF13747.6 PIK59974.1 - 5.4e-06 26.6 2.6 1.4e-05 25.3 2.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) Baculo_PEP_C PF04513.12 PIK59974.1 - 0.002 18.2 5.3 0.0035 17.4 4.4 1.9 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 PIK59974.1 - 0.0095 15.3 3.1 0.011 15.1 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) CortBP2 PF09727.9 PIK59974.1 - 0.02 14.8 5.6 0.035 14.0 5.6 1.4 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF2894 PF11445.8 PIK59974.1 - 0.022 15.2 0.6 0.03 14.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) UvrD_C PF13361.6 PIK59974.1 - 0.024 14.0 4.4 0.028 13.8 4.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain 4HB_MCP_1 PF12729.7 PIK59974.1 - 0.037 13.6 8.0 0.053 13.1 8.0 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction APG17 PF04108.12 PIK59974.1 - 0.063 12.4 10.1 0.1 11.7 10.1 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 C1_4 PF07975.12 PIK59974.1 - 0.073 13.3 7.5 0.086 13.1 3.1 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain SOGA PF11365.8 PIK59974.1 - 0.087 14.0 2.6 0.13 13.4 0.9 2.1 1 1 1 2 2 2 0 Protein SOGA UPF0449 PF15136.6 PIK59974.1 - 0.1 13.1 7.4 0.33 11.5 4.9 2.5 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 T3SS_needle_E PF08988.10 PIK59974.1 - 0.11 12.6 0.6 0.3 11.3 0.6 1.7 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle DNA_photolyase PF00875.18 PIK59974.1 - 0.13 12.3 1.4 0.23 11.4 1.1 1.5 1 1 0 1 1 1 0 DNA photolyase Cir_Bir_Yir PF06022.11 PIK59974.1 - 0.17 11.3 3.7 0.58 9.6 3.7 1.8 1 1 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir DUF1664 PF07889.12 PIK59974.1 - 0.28 11.2 10.7 0.12 12.4 5.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 PIK59974.1 - 0.73 10.0 6.3 7.5 6.8 0.2 3.0 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II MeaB PF03308.16 PIK59974.1 - 1.1 8.2 5.5 1.4 7.8 5.5 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ALMT PF11744.8 PIK59974.1 - 1.2 7.9 6.8 1.6 7.5 6.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Allexi_40kDa PF05549.11 PIK59974.1 - 1.3 8.5 6.8 0.59 9.6 4.4 1.6 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF743 PF05332.11 PIK59974.1 - 1.6 8.8 5.7 1.2 9.2 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF743) zf-RING_5 PF14634.6 PIK59974.1 - 4.7 7.3 12.0 7.9 6.5 7.0 2.4 2 0 0 2 2 2 0 zinc-RING finger domain zf-B_box PF00643.24 PIK59975.1 - 1.1e-11 44.7 7.3 1.1e-11 44.7 7.3 1.6 2 0 0 2 2 2 1 B-box zinc finger Tweety PF04906.13 PIK59975.1 - 0.00045 19.0 2.6 0.00072 18.3 2.6 1.3 1 0 0 1 1 1 1 Tweety DUF4164 PF13747.6 PIK59975.1 - 0.001 19.3 4.2 0.0011 19.2 2.3 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4164) Tektin PF03148.14 PIK59975.1 - 0.0039 16.0 7.0 0.0047 15.7 7.0 1.1 1 0 0 1 1 1 1 Tektin family DUF465 PF04325.13 PIK59975.1 - 0.019 15.0 3.9 0.04 14.0 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF465) APG17 PF04108.12 PIK59975.1 - 0.026 13.6 4.4 0.033 13.3 4.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 zf-UBR PF02207.20 PIK59975.1 - 0.028 14.6 5.8 0.055 13.6 5.8 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) C1_4 PF07975.12 PIK59975.1 - 0.033 14.4 3.9 0.091 13.0 3.9 1.8 1 0 0 1 1 1 0 TFIIH C1-like domain AAA_13 PF13166.6 PIK59975.1 - 0.035 12.8 5.9 0.041 12.5 5.9 1.1 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 PIK59975.1 - 0.051 13.6 8.9 0.036 14.1 7.3 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein T3SS_basalb_I PF17001.5 PIK59975.1 - 0.061 13.9 3.7 6.7 7.4 1.5 2.4 1 1 1 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI Tho2 PF11262.8 PIK59975.1 - 0.062 12.5 6.2 0.08 12.1 6.2 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Exonuc_VII_L PF02601.15 PIK59975.1 - 0.063 12.8 3.1 0.076 12.6 3.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 PIK59975.1 - 0.13 12.3 1.7 0.21 11.6 1.7 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4337 PF14235.6 PIK59975.1 - 0.15 12.1 3.6 0.24 11.5 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF1664 PF07889.12 PIK59975.1 - 0.24 11.4 7.7 0.37 10.8 7.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 PIK59975.1 - 0.3 10.0 2.6 0.32 9.9 2.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 PIK59975.1 - 0.42 9.9 5.7 0.55 9.5 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 PIK59975.1 - 0.63 10.5 10.2 0.12 12.7 6.7 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) Fzo_mitofusin PF04799.13 PIK59975.1 - 1.1 8.7 11.4 0.27 10.8 7.1 2.1 1 1 1 2 2 2 0 fzo-like conserved region DUF724 PF05266.14 PIK59975.1 - 1.6 8.5 8.3 2.3 8.0 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-C3HC4 PF00097.25 PIK59977.1 - 1.6e-08 34.3 10.4 1.6e-08 34.3 10.4 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK59977.1 - 2.3e-08 33.7 11.0 2.3e-08 33.7 11.0 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK59977.1 - 3.8e-08 33.2 8.0 3.8e-08 33.2 8.0 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 PIK59977.1 - 1.2e-07 31.5 6.7 1.2e-07 31.5 6.7 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK59977.1 - 4.3e-07 30.1 8.6 4.3e-07 30.1 8.6 3.2 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK59977.1 - 6.4e-07 29.4 11.5 6.4e-07 29.4 11.5 2.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 PIK59977.1 - 7.6e-06 25.8 9.0 7.6e-06 25.8 9.0 3.6 4 1 1 5 5 4 1 zinc-RING finger domain zf-B_box PF00643.24 PIK59977.1 - 2.2e-05 24.5 6.1 2.2e-05 24.5 6.1 4.0 5 1 0 5 5 5 2 B-box zinc finger Prok-RING_4 PF14447.6 PIK59977.1 - 0.00042 20.1 7.9 0.00042 20.1 7.9 3.0 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 PIK59977.1 - 0.014 15.1 4.9 0.067 12.9 4.9 2.3 1 0 0 1 1 1 0 RING-like zinc finger FYDLN_acid PF09538.10 PIK59977.1 - 1.5 9.5 5.2 0.88 10.3 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-B_box PF00643.24 PIK59978.1 - 6.8e-11 42.1 30.0 5.1e-09 36.2 12.6 2.4 2 0 0 2 2 2 2 B-box zinc finger DUF4294 PF14127.6 PIK59978.1 - 0.00027 20.9 0.9 0.0085 16.0 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4294) DUF4047 PF13256.6 PIK59978.1 - 0.0045 17.2 2.1 0.013 15.7 2.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4047) Pex19 PF04614.12 PIK59978.1 - 0.037 13.8 3.5 0.066 13.0 3.2 1.5 1 1 0 1 1 1 0 Pex19 protein family MbeB_N PF04837.12 PIK59978.1 - 0.072 13.4 2.4 0.16 12.3 1.0 2.2 2 0 0 2 2 2 0 MbeB-like, N-term conserved region Exonuc_VII_L PF02601.15 PIK59978.1 - 0.28 10.7 2.5 0.37 10.3 2.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 PIK59978.1 - 0.31 10.5 8.4 0.28 10.6 7.5 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 I_LWEQ PF01608.17 PIK59978.1 - 0.78 10.0 8.1 1.9 8.7 8.1 1.6 1 1 0 1 1 1 0 I/LWEQ domain Fibrinogen_C PF00147.18 PIK59980.1 - 9.4e-45 153.1 2.5 1.5e-44 152.4 2.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 PIK59980.1 - 0.01 15.1 0.2 0.014 14.7 0.2 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain Peptidase_C1 PF00112.23 PIK59981.1 - 5e-60 203.3 14.0 1e-58 199.0 7.0 3.0 2 1 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 PIK59981.1 - 2.4e-08 34.3 3.0 4.6e-08 33.4 3.0 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Cystatin PF00031.21 PIK59981.1 - 1.4e-06 28.5 1.2 3.7e-06 27.1 0.1 2.2 2 0 0 2 2 2 1 Cystatin domain Peptidase_C1_2 PF03051.15 PIK59981.1 - 3e-05 23.0 0.2 0.027 13.2 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family RT_RNaseH_2 PF17919.1 PIK59982.1 - 1e-32 112.1 0.0 2.1e-32 111.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK59982.1 - 2.2e-27 95.4 0.0 4.1e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK59982.1 - 3e-26 92.3 0.0 9e-26 90.8 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK59982.1 - 3.4e-13 49.5 0.0 8.3e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK59982.1 - 6.1e-05 23.2 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK59982.1 - 0.0098 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain FPP PF05911.11 PIK59984.1 - 0.00017 20.0 26.9 0.00017 20.0 26.9 2.1 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil Spectrin PF00435.21 PIK59984.1 - 0.0011 19.4 1.8 0.0011 19.4 1.8 5.2 3 1 2 5 5 5 1 Spectrin repeat DivIC PF04977.15 PIK59984.1 - 0.0012 18.5 33.5 0.32 10.8 0.4 5.3 3 1 0 4 4 4 3 Septum formation initiator FlaC_arch PF05377.11 PIK59984.1 - 0.0048 17.3 29.1 0.52 10.7 0.6 5.3 6 0 0 6 6 4 3 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 PIK59984.1 - 0.0057 16.7 52.5 0.34 10.9 1.3 5.2 3 1 2 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 PIK59984.1 - 0.0095 15.3 34.8 0.089 12.1 0.8 4.2 1 1 1 4 4 4 3 Protein of unknown function (DUF3450) Lebercilin PF15619.6 PIK59984.1 - 0.02 14.6 42.9 0.036 13.7 33.9 2.6 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 PIK59984.1 - 0.032 14.3 33.2 0.16 12.1 2.5 6.0 5 1 1 6 6 6 0 bZIP transcription factor GIT_CC PF16559.5 PIK59984.1 - 0.037 13.9 23.1 0.2 11.5 1.0 5.7 4 2 2 6 6 6 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF948 PF06103.11 PIK59984.1 - 0.038 14.2 15.8 1 9.7 0.7 4.7 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Troponin PF00992.20 PIK59984.1 - 0.06 13.7 0.3 0.06 13.7 0.3 4.3 1 1 2 4 4 3 0 Troponin Golgin_A5 PF09787.9 PIK59984.1 - 0.14 11.6 40.8 0.92 8.9 18.8 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 CCDC92 PF14916.6 PIK59984.1 - 0.17 11.7 11.5 3.9 7.3 0.7 4.1 3 0 0 3 3 3 0 Coiled-coil domain of unknown function UPF0242 PF06785.11 PIK59984.1 - 0.18 11.9 42.9 5.9 6.9 11.6 3.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Phage_GP20 PF06810.11 PIK59984.1 - 0.22 11.3 47.6 0.027 14.3 11.3 4.6 2 2 2 4 4 4 0 Phage minor structural protein GP20 ADIP PF11559.8 PIK59984.1 - 0.26 11.3 40.3 3.8 7.6 2.1 4.3 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding KASH_CCD PF14662.6 PIK59984.1 - 0.56 10.0 42.9 0.51 10.2 23.3 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Csm1_N PF18504.1 PIK59984.1 - 0.85 10.0 36.5 8.8 6.7 2.6 5.5 3 1 2 5 5 5 0 Csm1 N-terminal domain ATG16 PF08614.11 PIK59984.1 - 1.7 8.8 47.9 0.043 14.0 3.1 4.8 1 1 2 5 5 5 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK59984.1 - 1.9 8.9 41.1 1.6 9.1 3.4 3.3 1 1 1 3 3 3 0 Fez1 FH2 PF02181.23 PIK59984.1 - 2.1 7.4 25.8 0.16 11.1 6.5 4.0 1 1 3 4 4 4 0 Formin Homology 2 Domain Spc7 PF08317.11 PIK59984.1 - 4.6 6.0 48.1 0.58 9.0 16.3 3.2 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.6 PIK59984.1 - 5.7 6.2 31.8 0.88 8.9 7.4 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 PIK59984.1 - 6.2 7.3 50.2 1.5 9.3 2.0 4.5 2 1 2 4 4 4 0 Apg6 coiled-coil region TolA_bind_tri PF16331.5 PIK59984.1 - 8.7 6.5 17.8 6.7 6.9 0.1 4.7 4 2 0 4 4 4 0 TolA binding protein trimerisation SlyX PF04102.12 PIK59984.1 - 8.7 7.0 26.7 4.6 7.9 0.3 5.3 5 0 0 5 5 4 0 SlyX Tropomyosin_1 PF12718.7 PIK59984.1 - 9 6.4 50.6 3.1 8.0 8.0 4.4 2 1 1 4 4 4 0 Tropomyosin like CENP-Q PF13094.6 PIK59984.1 - 9.8 6.3 46.5 27 4.9 16.8 5.7 1 1 2 4 4 3 0 CENP-Q, a CENPA-CAD centromere complex subunit SH3_2 PF07653.17 PIK59985.1 - 3.8e-07 29.7 0.0 6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 PIK59985.1 - 0.0049 16.4 0.4 0.083 12.5 0.1 2.7 2 0 0 2 2 2 1 SH3 domain NAM-associated PF14303.6 PIK59985.1 - 0.048 14.4 1.0 0.048 14.4 1.0 3.0 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain 2-oxoacid_dh PF00198.23 PIK59986.1 - 1.3e-57 194.9 0.0 1.8e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 PIK59986.1 - 2.6e-15 56.0 3.1 4.3e-15 55.3 3.1 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 PIK59986.1 - 2.9e-05 23.8 2.9 0.00015 21.5 0.5 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 PIK59986.1 - 0.0064 15.7 0.1 0.0098 15.1 0.1 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 PIK59986.1 - 0.046 13.6 0.3 0.094 12.6 0.3 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_3 PF13437.6 PIK59986.1 - 0.091 13.5 0.9 0.23 12.2 0.3 1.8 1 1 1 2 2 2 0 HlyD family secretion protein RnfC_N PF13375.6 PIK59986.1 - 0.17 11.9 1.2 0.59 10.1 1.2 1.9 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain F420_oxidored PF03807.17 PIK59987.1 - 5.8e-10 39.6 0.0 1.1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 PIK59987.1 - 0.00046 20.4 0.0 0.00076 19.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 PIK59987.1 - 0.019 14.8 0.0 0.054 13.4 0.0 1.6 1 1 0 1 1 1 0 Rossmann-like domain DSPc PF00782.20 PIK59988.1 - 3e-38 130.7 0.1 7.2e-38 129.4 0.1 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 PIK59988.1 - 1.2e-11 45.1 0.0 2.2e-10 41.0 0.0 2.5 2 0 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.6 PIK59988.1 - 1.1e-05 25.7 0.0 2.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 PIK59988.1 - 0.001 18.7 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF442 PF04273.13 PIK59988.1 - 0.04 14.0 0.0 0.44 10.7 0.0 2.3 1 1 0 1 1 1 0 Putative phosphatase (DUF442) Init_tRNA_PT PF04179.12 PIK59988.1 - 0.074 13.4 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 Rit1 DUSP-like domain Solute_trans_a PF03619.16 PIK59989.1 - 1.2e-29 103.7 17.1 1.5e-29 103.3 17.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Solute_trans_a PF03619.16 PIK59990.1 - 4.5e-25 88.7 16.3 2.4e-24 86.3 5.3 2.4 1 1 1 2 2 2 2 Organic solute transporter Ostalpha zf-MYND PF01753.18 PIK59991.1 - 2.2e-11 43.7 12.8 2.2e-11 43.7 12.8 2.1 2 0 0 2 2 2 1 MYND finger 2OG-FeII_Oxy_3 PF13640.6 PIK59991.1 - 1.8e-05 25.5 0.0 4.7e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 PIK59991.1 - 0.099 13.3 0.0 0.33 11.7 0.0 1.9 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily zf-Mss51 PF13824.6 PIK59991.1 - 0.21 11.7 9.0 0.52 10.5 9.0 1.7 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Vault_4 PF17796.1 PIK59992.1 - 0.031 14.3 0.0 0.099 12.7 0.0 1.8 2 0 0 2 2 2 0 Major Vault Protein repeat domain Forkhead PF00250.18 PIK59993.1 - 4.8e-36 122.9 0.0 7.9e-36 122.2 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain Forkhead_N PF08430.12 PIK59993.1 - 1.9e-07 31.7 53.8 1.9e-07 31.7 53.8 3.7 2 2 1 3 3 3 1 Forkhead N-terminal region DpnI_C PF17726.1 PIK59993.1 - 0.12 12.5 0.2 0.23 11.6 0.2 1.3 1 0 0 1 1 1 0 Dam-replacing HTH domain YcgR PF07317.12 PIK59994.1 - 0.011 15.5 1.1 0.03 14.2 1.1 1.7 1 0 0 1 1 1 0 Flagellar regulator YcgR PAX PF00292.18 PIK59995.1 - 4.1e-35 120.4 0.1 6.8e-35 119.7 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 PIK59995.1 - 0.00086 19.9 0.0 0.0016 19.0 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain cNMP_binding PF00027.29 PIK59996.1 - 4.5e-20 71.5 0.0 9.5e-20 70.5 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Thx PF17070.5 PIK59996.1 - 2.3 8.4 5.9 1.1 9.4 0.3 2.7 3 0 0 3 3 3 0 30S ribosomal protein Thx Myc_N PF01056.18 PIK59997.1 - 0.016 15.1 1.0 0.023 14.6 1.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 PIK59997.1 - 0.26 10.6 1.7 0.35 10.1 1.7 1.2 1 0 0 1 1 1 0 NOA36 protein Homeodomain PF00046.29 PIK59998.1 - 4.6e-19 68.0 6.2 7.1e-19 67.4 6.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK59998.1 - 0.083 12.8 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 PIK59999.1 - 1.9e-09 37.2 2.3 2.7e-09 36.7 2.3 1.2 1 0 0 1 1 1 1 Homeodomain RT_RNaseH_2 PF17919.1 PIK60000.1 - 2.9e-36 123.5 0.0 2.9e-36 123.5 0.0 2.8 4 0 0 4 4 4 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60000.1 - 8e-35 119.3 0.1 2.5e-34 117.7 0.0 2.0 2 0 0 2 2 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60000.1 - 1.9e-26 92.9 0.0 3.4e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK60000.1 - 1.1e-18 67.0 0.1 3.4e-18 65.5 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK60000.1 - 1.8e-16 60.4 0.0 4.7e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain SCAN PF02023.17 PIK60000.1 - 6e-13 48.4 0.0 1.9e-12 46.8 0.0 1.9 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK60000.1 - 3.6e-06 26.8 2.0 9.9e-06 25.4 2.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 PIK60000.1 - 0.0018 18.4 0.0 0.0018 18.4 0.0 2.4 3 0 0 3 3 3 1 H2C2 zinc finger zf-CCHC_2 PF13696.6 PIK60000.1 - 0.0089 15.8 1.4 0.019 14.8 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.6 PIK60000.1 - 0.015 15.1 0.2 0.089 12.6 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain NodZ PF05830.11 PIK60000.1 - 0.18 10.6 1.4 2.5 6.9 0.0 2.2 2 0 0 2 2 2 0 Nodulation protein Z (NodZ) DUF4407 PF14362.6 PIK60000.1 - 0.67 9.2 6.0 2 7.7 6.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ank_2 PF12796.7 PIK60001.1 - 6.6e-15 55.5 0.0 1.1e-09 38.8 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK60001.1 - 8.9e-14 51.4 0.0 1.3e-08 34.9 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK60001.1 - 7.4e-11 42.0 0.0 6e-05 23.3 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 PIK60001.1 - 8e-09 35.9 0.0 2.8e-05 24.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK60001.1 - 8.2e-09 35.0 0.0 0.018 15.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat HECT PF00632.25 PIK60002.1 - 8.8e-44 150.2 0.0 2.6e-43 148.6 0.0 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) BTHB PF18410.1 PIK60002.1 - 6.3e-19 67.6 0.0 1.4e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Basic tilted helix bundle domain Sad1_UNC PF07738.13 PIK60002.1 - 4e-15 56.0 0.0 7.7e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 PIK60002.1 - 0.00042 20.4 0.1 0.001 19.2 0.1 1.7 1 0 0 1 1 1 1 F5/8 type C domain DUF148 PF02520.17 PIK60002.1 - 0.24 11.5 1.0 0.5 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 TFIIA PF03153.13 PIK60002.1 - 2.2 8.2 16.3 0.48 10.4 11.8 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CD20 PF04103.15 PIK60003.1 - 7.9e-10 39.0 11.8 2.6e-09 37.4 11.5 2.0 1 1 0 1 1 1 1 CD20-like family DUF3464 PF11947.8 PIK60003.1 - 0.0092 15.7 3.0 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 Photosynthesis affected mutant 68 Phage_holin_3_6 PF07332.11 PIK60003.1 - 0.4 10.7 11.1 1.9 8.6 0.4 2.5 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III 3-HAO PF06052.12 PIK60004.1 - 1.3e-67 226.2 0.1 1.1e-60 203.7 0.1 2.0 2 0 0 2 2 2 2 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 PIK60004.1 - 1.3e-06 28.0 0.0 0.00011 21.8 0.0 2.4 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.19 PIK60004.1 - 0.0067 16.3 0.0 0.79 9.6 0.0 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_6 PF12852.7 PIK60004.1 - 0.062 13.0 0.0 2.3 7.9 0.0 2.1 2 0 0 2 2 2 0 Cupin Aldedh PF00171.22 PIK60005.1 - 3.5e-126 421.4 0.3 4.3e-126 421.1 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 PIK60005.1 - 0.11 11.5 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) HpaB PF03241.13 PIK60005.1 - 0.15 11.1 0.3 1.2 8.2 0.1 2.1 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal SH2 PF00017.24 PIK60006.1 - 2.6e-08 33.8 0.5 5.5e-08 32.8 0.1 1.8 2 0 0 2 2 2 1 SH2 domain Lectin_C PF00059.21 PIK60007.1 - 1.7e-20 73.7 0.2 2.7e-20 73.1 0.2 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK60007.1 - 1.4e-05 24.8 0.0 2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK60008.1 - 2.5e-21 76.4 1.3 3.3e-21 76.0 1.3 1.2 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 PIK60008.1 - 0.0022 17.3 0.1 0.0048 16.2 0.1 1.6 2 0 0 2 2 2 1 Chordopoxvirus A33R protein UL45 PF05473.12 PIK60008.1 - 0.027 14.1 0.3 0.044 13.4 0.3 1.6 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK60009.1 - 5e-22 78.7 1.2 6.8e-22 78.3 1.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 PIK60009.1 - 0.0037 16.6 0.1 0.007 15.7 0.1 1.4 1 0 0 1 1 1 1 Chordopoxvirus A33R protein UL45 PF05473.12 PIK60009.1 - 0.013 15.1 0.2 0.019 14.6 0.2 1.6 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK60010.1 - 1.5e-17 64.3 0.1 2.2e-17 63.7 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK60010.1 - 0.00082 19.1 0.4 0.0016 18.1 0.1 1.5 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK60011.1 - 8.9e-19 68.2 0.3 1.3e-18 67.7 0.3 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK60011.1 - 0.00051 19.7 0.1 0.00091 18.9 0.0 1.5 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like UL45 PF05473.12 PIK60012.1 - 3e-05 23.8 0.2 3.3e-05 23.6 0.2 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Mito_carr PF00153.27 PIK60013.1 - 4.2e-62 206.1 4.4 2.8e-22 78.5 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Spy1 PF11357.8 PIK60014.1 - 2.8e-36 124.7 0.2 3e-36 124.6 0.2 1.0 1 0 0 1 1 1 1 Cell cycle regulatory protein GCD14 PF08704.10 PIK60015.1 - 2e-16 60.4 0.1 4.7e-16 59.2 0.0 1.6 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 PIK60015.1 - 3.2e-08 33.6 0.0 6e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 PIK60015.1 - 0.0016 19.1 0.0 0.0039 17.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK60015.1 - 0.0019 18.9 0.0 0.0047 17.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 PIK60015.1 - 0.0063 16.3 0.1 0.015 15.1 0.1 1.7 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_23 PF13489.6 PIK60015.1 - 0.025 14.4 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 PIK60015.1 - 0.026 15.5 0.0 0.058 14.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 PIK60015.1 - 0.057 13.2 0.0 0.2 11.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 PIK60015.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DHC_N1 PF08385.12 PIK60016.1 - 1.7e-32 112.8 0.0 2.1e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 PIK60017.1 - 1.1e-115 387.0 13.7 1.1e-115 387.0 13.7 3.5 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 PIK60017.1 - 6.7e-83 279.2 0.1 6.7e-83 279.2 0.1 3.5 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 PIK60017.1 - 9.1e-77 258.2 10.7 1.3e-76 257.7 0.1 5.0 5 1 0 5 5 5 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 PIK60017.1 - 2.2e-47 161.6 0.1 2.4e-23 82.8 0.0 4.1 3 1 1 4 4 4 2 P-loop containing dynein motor region D4 AAA_7 PF12775.7 PIK60017.1 - 9.2e-44 149.1 0.0 4.4e-38 130.6 0.0 4.6 5 0 0 5 5 5 2 P-loop containing dynein motor region AAA_5 PF07728.14 PIK60017.1 - 5.4e-24 84.8 0.0 2e-09 37.6 0.0 6.3 6 0 0 6 6 5 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 PIK60017.1 - 2.7e-17 63.1 0.0 9.4e-17 61.3 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 PIK60017.1 - 1.8e-13 51.0 0.0 0.0033 17.7 0.0 5.9 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.6 PIK60017.1 - 2.1e-10 41.0 0.5 0.058 13.6 0.0 4.9 5 0 0 5 5 3 3 AAA domain AAA_18 PF13238.6 PIK60017.1 - 2.9e-09 37.6 2.9 0.15 12.6 0.0 7.2 8 0 0 8 8 5 2 AAA domain AAA PF00004.29 PIK60017.1 - 1.1e-08 35.5 0.0 0.065 13.7 0.0 4.5 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK60017.1 - 5.6e-08 33.3 3.3 0.56 10.6 0.0 5.9 7 0 0 7 7 5 2 AAA ATPase domain Mg_chelatase PF01078.21 PIK60017.1 - 6.8e-07 28.9 0.9 0.42 10.0 0.0 5.2 6 0 0 6 6 5 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 PIK60017.1 - 7.6e-07 29.7 1.2 0.16 12.5 0.0 5.3 4 0 0 4 4 4 2 ABC transporter AAA_29 PF13555.6 PIK60017.1 - 5.3e-06 26.1 0.1 0.45 10.3 0.0 3.6 3 0 0 3 3 3 2 P-loop containing region of AAA domain T2SSE PF00437.20 PIK60017.1 - 1.8e-05 23.9 0.0 0.12 11.5 0.0 3.8 3 0 0 3 3 3 1 Type II/IV secretion system protein MT PF12777.7 PIK60017.1 - 2.3e-05 23.6 12.4 4.4e-05 22.7 12.4 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_30 PF13604.6 PIK60017.1 - 4.8e-05 23.2 0.0 3.5 7.3 0.0 3.9 3 0 0 3 3 3 2 AAA domain FtsK_SpoIIIE PF01580.18 PIK60017.1 - 9.4e-05 21.9 0.0 1.7 8.0 0.0 3.7 3 0 0 3 3 3 2 FtsK/SpoIIIE family AAA_lid_1 PF17857.1 PIK60017.1 - 0.00011 22.3 0.7 0.00075 19.7 0.0 2.8 3 0 0 3 3 2 1 AAA+ lid domain AAA_19 PF13245.6 PIK60017.1 - 0.00014 22.2 0.0 0.2 12.0 0.0 3.9 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 PIK60017.1 - 0.0002 21.3 0.0 4.1 7.3 0.0 3.8 3 0 0 3 3 3 1 Rad17 P-loop domain NACHT PF05729.12 PIK60017.1 - 0.00065 19.6 0.3 32 4.4 0.0 4.9 4 0 0 4 4 4 0 NACHT domain IstB_IS21 PF01695.17 PIK60017.1 - 0.00079 19.2 0.0 0.28 10.9 0.0 4.2 4 0 0 4 4 4 1 IstB-like ATP binding protein RsgA_GTPase PF03193.16 PIK60017.1 - 0.00081 19.3 0.4 11 5.8 0.0 4.1 4 0 0 4 4 3 0 RsgA GTPase RNA_helicase PF00910.22 PIK60017.1 - 0.0013 19.1 0.8 4.5 7.7 0.0 5.1 5 0 0 5 5 5 1 RNA helicase AAA_25 PF13481.6 PIK60017.1 - 0.0054 16.3 0.1 0.44 10.1 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 PIK60017.1 - 0.0091 15.7 0.1 21 4.7 0.0 4.1 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 PIK60017.1 - 0.011 15.7 0.1 4.9 7.2 0.0 3.7 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 PIK60017.1 - 0.03 14.1 0.1 0.79 9.5 0.0 2.8 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain dNK PF01712.19 PIK60017.1 - 0.28 11.0 5.4 0.55 10.0 0.1 4.1 5 0 0 5 5 3 0 Deoxynucleoside kinase DUF3987 PF13148.6 PIK60017.1 - 0.44 9.5 0.0 0.44 9.5 0.0 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3987) CENP-O PF09496.10 PIK60017.1 - 2.4 8.1 7.4 16 5.4 7.4 2.5 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF4407 PF14362.6 PIK60017.1 - 2.5 7.4 14.7 2.4 7.5 9.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Rad9 PF04139.13 PIK60018.1 - 4.2e-80 268.8 0.0 5.3e-80 268.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Metallophos_2 PF12850.7 PIK60019.1 - 2.8e-21 76.4 0.1 3.5e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 PIK60019.1 - 0.0002 21.9 0.8 0.26 11.8 0.1 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase FAM216B PF15107.6 PIK60020.1 - 0.0049 16.7 2.6 0.0079 16.1 0.0 2.1 2 0 0 2 2 2 1 FAM216B protein family DAO PF01266.24 PIK60021.1 - 3.3e-17 63.1 0.0 4.9e-16 59.3 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 PIK60021.1 - 0.00045 19.6 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK60022.1 - 0.00037 20.2 0.0 0.00043 20.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 PIK60023.1 - 9.1e-16 58.4 0.0 9.7e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sugar_tr PF00083.24 PIK60024.1 - 4.9e-12 45.4 0.4 3.1e-06 26.3 0.1 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK60024.1 - 7e-09 35.1 10.0 1.5e-07 30.7 2.3 2.4 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_5 PF05631.14 PIK60024.1 - 0.0091 15.0 0.1 0.014 14.3 0.1 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_2 PF13347.6 PIK60024.1 - 0.018 13.6 2.1 0.023 13.3 0.4 2.0 2 0 0 2 2 2 0 MFS/sugar transport protein CDC45 PF02724.14 PIK60025.1 - 4.3e-147 491.1 13.5 6.6e-142 474.0 13.5 3.0 1 1 0 1 1 1 1 CDC45-like protein DUF240 PF03086.14 PIK60025.1 - 0.027 14.4 1.9 0.062 13.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF240) HGD-D PF06050.13 PIK60025.1 - 0.083 12.6 0.4 3.5 7.3 0.1 2.3 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component PAXIP1_C PF15364.6 PIK60026.1 - 8.6e-29 100.6 1.4 8.6e-29 100.6 1.4 1.6 2 0 0 2 2 2 1 PAXIP1-associated-protein-1 C term PTIP binding protein HTH_40 PF14493.6 PIK60026.1 - 0.27 11.7 1.2 95 3.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain Thiamine_BP PF01910.17 PIK60027.1 - 0.0038 17.1 4.4 0.0063 16.4 0.9 2.2 2 0 0 2 2 2 1 Thiamine-binding protein MAAL_N PF05034.13 PIK60027.1 - 0.25 11.0 1.0 1.2 8.8 0.2 1.9 1 1 1 2 2 2 0 Methylaspartate ammonia-lyase N-terminus Hira PF07569.11 PIK60028.1 - 6.1e-34 117.7 0.2 7.7e-34 117.4 0.2 1.1 1 0 0 1 1 1 1 TUP1-like enhancer of split DUF2520 PF10728.9 PIK60028.1 - 0.086 12.6 0.0 0.11 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2520) Hira PF07569.11 PIK60029.1 - 6e-12 45.8 1.4 9e-12 45.2 0.0 2.0 2 1 0 2 2 2 1 TUP1-like enhancer of split RCC1_2 PF13540.6 PIK60029.1 - 0.022 14.6 4.8 0.47 10.3 0.2 2.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat gag-asp_proteas PF13975.6 PIK60030.1 - 1.3e-07 32.1 0.1 3.4e-07 30.7 0.1 1.8 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK60030.1 - 1.4e-06 28.8 0.1 3.1e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF1759 PF03564.15 PIK60030.1 - 3.2e-06 27.1 0.0 6.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Integrase_H2C2 PF17921.1 PIK60031.1 - 2.4e-07 30.7 0.5 5.4e-07 29.6 0.5 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK60031.1 - 3.8e-05 23.9 0.0 7.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK60031.1 - 0.0025 18.0 0.4 0.0055 16.9 0.4 1.6 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC_6 PF15288.6 PIK60031.1 - 0.07 13.0 0.3 0.15 11.9 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle WD40 PF00400.32 PIK60032.1 - 1.2e-15 57.6 8.3 9.7e-08 32.6 3.1 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60032.1 - 0.0012 19.1 0.3 1.1 9.7 0.1 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK60033.1 - 0.02 15.8 0.0 0.18 12.7 0.0 2.0 2 0 0 2 2 2 0 WD domain, G-beta repeat zf-RING_UBOX PF13445.6 PIK60034.1 - 4.1e-10 39.5 5.5 1.2e-09 38.0 5.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK60034.1 - 2.3e-09 37.0 8.8 8.7e-09 35.1 8.8 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK60034.1 - 3.9e-09 36.7 8.4 1.3e-08 35.1 8.4 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK60034.1 - 1.5e-08 34.3 9.4 3.3e-08 33.3 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK60034.1 - 1.4e-07 31.2 8.6 1.6e-07 31.0 7.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK60034.1 - 3.7e-07 30.0 7.9 1.2e-06 28.3 7.9 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK60034.1 - 1.4e-06 28.3 9.5 1.4e-06 28.3 9.5 2.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING NHL PF01436.21 PIK60034.1 - 2.1e-06 27.5 0.6 1.6 9.0 0.0 3.9 4 0 0 4 4 4 3 NHL repeat Filamin PF00630.19 PIK60034.1 - 1.3e-05 26.0 0.0 3.4e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat Prok-RING_4 PF14447.6 PIK60034.1 - 2.6e-05 24.0 10.0 0.0007 19.4 9.9 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 PIK60034.1 - 0.099 12.8 7.1 0.083 13.0 5.0 2.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 PIK60034.1 - 0.25 11.4 5.4 0.58 10.2 5.4 1.6 1 0 0 1 1 1 0 zinc-ribbons SBBP PF06739.11 PIK60034.1 - 0.28 11.2 1.6 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Beta-propeller repeat zf-rbx1 PF12678.7 PIK60034.1 - 0.44 10.9 9.1 3 8.2 9.1 2.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 PIK60034.1 - 1.2 9.0 10.3 0.23 11.3 5.6 2.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain KDZ PF18758.1 PIK60035.1 - 3.6e-09 36.6 0.4 3.6e-09 36.6 0.4 1.6 2 0 0 2 2 2 1 Kyakuja-Dileera-Zisupton transposase Clathrin_lg_ch PF01086.17 PIK60035.1 - 0.021 14.9 1.6 0.032 14.3 0.0 2.2 3 0 0 3 3 3 0 Clathrin light chain DLP_helical PF18709.1 PIK60035.1 - 0.57 9.3 9.3 0.032 13.4 1.0 2.6 3 0 0 3 3 3 0 Dynamin-like helical domain GTF2I PF02946.14 PIK60036.1 - 7.8e-13 48.3 0.0 1.6e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 GTF2I-like repeat Chromo PF00385.24 PIK60036.1 - 4.8e-11 42.4 0.4 1.3e-10 41.0 0.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 PIK60036.1 - 4.3e-05 23.3 0.2 0.0001 22.1 0.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 PIK60036.1 - 0.0098 16.0 0.3 0.05 13.8 0.2 2.1 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 ROS_MUCR PF05443.11 PIK60037.1 - 0.00013 22.0 3.6 0.012 15.7 0.5 2.2 2 0 0 2 2 2 2 ROS/MUCR transcriptional regulator protein FOXP-CC PF16159.5 PIK60037.1 - 0.00055 20.5 6.9 0.0058 17.2 1.8 2.4 2 1 0 2 2 2 2 FOXP coiled-coil domain Amino_oxidase PF01593.24 PIK60038.1 - 8.1e-07 28.7 0.0 8.1e-07 28.7 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 PIK60038.1 - 0.03 13.9 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase SSF PF00474.17 PIK60039.1 - 1.3e-132 442.5 25.7 1.9e-132 442.0 25.7 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2569 PF10754.9 PIK60039.1 - 0.023 15.1 2.9 0.023 15.1 2.9 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2569) Toxin_2 PF00451.19 PIK60039.1 - 0.58 10.5 2.7 1.1 9.7 2.7 1.4 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 Rx_N PF18052.1 PIK60040.1 - 6.2 7.2 7.3 7.8 6.9 3.9 2.1 2 0 0 2 2 2 0 Rx N-terminal domain DUF4588 PF15251.6 PIK60042.1 - 0.014 15.2 1.2 0.015 15.0 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) DHR10 PF18595.1 PIK60042.1 - 0.026 14.6 5.6 0.03 14.4 5.6 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF641 PF04859.12 PIK60042.1 - 0.044 14.1 1.5 0.053 13.9 1.5 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF3574 PF12098.8 PIK60043.1 - 0.064 13.0 0.6 0.17 11.7 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) DUF1664 PF07889.12 PIK60043.1 - 1.5 8.8 8.5 1.7 8.7 0.3 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF641 PF04859.12 PIK60044.1 - 0.0029 18.0 5.9 0.0029 18.0 5.9 3.7 1 1 2 3 3 2 1 Plant protein of unknown function (DUF641) MCC-bdg_PDZ PF10506.9 PIK60044.1 - 0.0031 17.5 1.6 0.0031 17.5 1.6 3.3 3 1 0 3 3 3 1 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF3584 PF12128.8 PIK60044.1 - 0.0058 14.2 31.1 0.008 13.8 31.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Golgin_A5 PF09787.9 PIK60044.1 - 0.0073 15.8 33.0 0.0073 15.8 33.0 1.9 1 1 1 2 2 2 1 Golgin subfamily A member 5 KxDL PF10241.9 PIK60044.1 - 0.0096 16.2 24.5 0.087 13.1 4.4 3.2 2 1 1 3 3 3 2 Uncharacterized conserved protein PRKG1_interact PF15898.5 PIK60044.1 - 0.042 14.7 17.3 0.042 14.7 17.3 3.2 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Apolipoprotein PF01442.18 PIK60044.1 - 0.32 10.9 29.5 0.2 11.5 14.5 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain V_ATPase_I PF01496.19 PIK60044.1 - 0.33 8.8 23.7 0.41 8.5 23.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HAUS-augmin3 PF14932.6 PIK60044.1 - 1.1 8.8 31.1 0.031 13.9 5.9 2.5 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 UPF0061 PF02696.14 PIK60044.1 - 1.1 7.9 10.8 1.4 7.6 10.8 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family Spc7 PF08317.11 PIK60044.1 - 1.5 7.6 45.1 0.71 8.7 28.9 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4201 PF13870.6 PIK60044.1 - 2 8.1 44.4 7.6 6.2 17.9 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF883 PF05957.13 PIK60044.1 - 3.2 8.4 19.3 0.16 12.6 3.5 3.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) ATG16 PF08614.11 PIK60044.1 - 4.6 7.4 39.2 2.1 8.5 21.7 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) IFT57 PF10498.9 PIK60044.1 - 4.8 6.1 33.7 1.8 7.5 7.2 2.5 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 zf-C4pol PF14260.6 PIK60044.1 - 4.8 7.7 13.8 0.73 10.3 3.3 3.7 2 2 1 4 4 4 0 C4-type zinc-finger of DNA polymerase delta Fib_alpha PF08702.10 PIK60044.1 - 6.9 6.8 35.7 7.7 6.7 2.0 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family GAS PF13851.6 PIK60044.1 - 8.7 5.6 45.4 4.4 6.6 27.0 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding XRCC1_N PF01834.16 PIK60045.1 - 0.026 14.5 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 XRCC1 N terminal domain GLE1 PF07817.13 PIK60046.1 - 2.5e-06 26.9 0.1 2.5e-06 26.9 0.1 2.3 2 1 0 2 2 2 1 GLE1-like protein PHAT PF09246.10 PIK60046.1 - 0.022 14.6 0.0 0.069 13.0 0.0 1.8 1 0 0 1 1 1 0 PHAT GLE1 PF07817.13 PIK60047.1 - 8.7e-32 110.3 0.0 1.3e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 GLE1-like protein BRAP2 PF07576.12 PIK60048.1 - 5.5e-32 109.9 0.2 1.3e-31 108.8 0.2 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 PIK60048.1 - 1.7e-21 76.3 6.8 4.4e-21 75.0 6.8 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein RRM_1 PF00076.22 PIK60048.1 - 0.01 15.6 0.0 0.03 14.1 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 PIK60048.1 - 0.017 14.9 4.8 0.93 9.4 2.3 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-UBP_var PF17807.1 PIK60048.1 - 0.062 13.1 2.2 0.16 11.7 2.2 1.7 1 0 0 1 1 1 0 Variant UBP zinc finger Apolipoprotein PF01442.18 PIK60048.1 - 1.1 9.1 13.0 3.1 7.6 13.0 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Med9 PF07544.13 PIK60048.1 - 6.1 7.0 13.2 13 6.0 6.8 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.12 PIK60048.1 - 6.7 6.8 8.6 1 9.4 1.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 PIK60048.1 - 9 5.5 8.5 18 4.6 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 PIK60048.1 - 9.6 6.0 17.5 2.3 8.0 6.9 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 Collagen PF01391.18 PIK60049.1 - 0.00048 19.8 8.9 0.00048 19.8 8.9 1.5 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Dynamin_M PF01031.20 PIK60050.1 - 0.16 11.1 4.9 7.6 5.7 3.1 2.3 2 0 0 2 2 2 0 Dynamin central region EST1 PF10374.9 PIK60050.1 - 0.36 11.5 4.3 0.5 11.0 2.8 2.0 2 0 0 2 2 2 0 Telomerase activating protein Est1 GTP-bdg_M PF16360.5 PIK60050.1 - 0.36 11.4 4.3 0.5 11.0 0.2 2.7 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Gamma_PGA_hydro PF05908.11 PIK60050.1 - 0.5 9.7 2.9 0.71 9.2 1.1 1.9 1 1 0 2 2 2 0 Poly-gamma-glutamate hydrolase Endonuc_Holl PF10107.9 PIK60050.1 - 0.78 9.6 6.6 89 2.9 6.6 2.4 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase HYR PF02494.16 PIK60051.1 - 4.2e-10 39.8 0.0 9.1e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 HYR domain Shisa PF13908.6 PIK60051.1 - 0.045 14.0 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK60051.1 - 0.11 13.4 0.0 0.17 12.8 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CUB PF00431.20 PIK60052.1 - 2.7e-43 146.8 0.0 5.9e-21 74.9 0.0 2.5 2 0 0 2 2 2 2 CUB domain Ldl_recept_b PF00058.17 PIK60052.1 - 7.1e-16 58.4 7.8 0.0048 17.4 0.0 6.9 7 0 0 7 7 7 5 Low-density lipoprotein receptor repeat class B HYR PF02494.16 PIK60052.1 - 1.5e-10 41.2 0.1 5.3e-10 39.5 0.1 2.0 1 0 0 1 1 1 1 HYR domain DUF5050 PF16472.5 PIK60052.1 - 6.6e-05 22.3 0.4 2 7.6 0.0 3.4 3 1 0 3 3 3 2 Domain of unknown function (DUF5050) SGL PF08450.12 PIK60052.1 - 0.0042 16.7 0.3 0.44 10.1 0.0 3.4 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 PIK60052.1 - 0.11 12.8 1.1 0.32 11.3 1.1 1.9 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site CUB PF00431.20 PIK60053.1 - 2.7e-05 24.5 0.0 3.7e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 CUB domain Ldl_recept_b PF00058.17 PIK60054.1 - 8.5e-11 42.2 0.1 2.1e-05 24.9 0.0 4.5 4 0 0 4 4 4 2 Low-density lipoprotein receptor repeat class B CUB PF00431.20 PIK60054.1 - 1.2e-05 25.6 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 CUB domain Peptidase_M14 PF00246.24 PIK60055.1 - 2.4e-63 214.6 0.0 3e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK60055.1 - 2.2e-09 37.6 0.5 1.2e-08 35.2 0.8 2.1 2 0 0 2 2 2 1 Carboxypeptidase activation peptide DUF2812 PF11193.8 PIK60055.1 - 0.043 14.0 0.0 0.27 11.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2812) tRNA_deacylase PF04414.12 PIK60055.1 - 0.082 12.4 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase EKLF_TAD1 PF16832.5 PIK60055.1 - 0.098 12.5 0.5 0.2 11.5 0.5 1.5 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 Fibrinogen_C PF00147.18 PIK60056.1 - 3e-62 210.3 3.6 3.6e-62 210.0 3.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Excalibur PF05901.11 PIK60056.1 - 0.089 13.4 0.1 0.27 11.9 0.1 1.8 1 0 0 1 1 1 0 Excalibur calcium-binding domain Sulfotransfer_2 PF03567.14 PIK60057.1 - 1.5e-23 84.1 0.3 1.8e-23 83.8 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK60058.1 - 1.5e-32 113.5 0.1 2.9e-32 112.6 0.1 1.4 1 1 0 1 1 1 1 Sulfotransferase family RVT_1 PF00078.27 PIK60059.1 - 6.5e-23 81.4 0.2 1.2e-22 80.5 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK60059.1 - 2.5e-21 75.6 0.1 7.1e-21 74.1 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK60059.1 - 7.8e-20 70.7 0.0 1.7e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK60059.1 - 3.9e-19 68.9 0.0 7.8e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK60059.1 - 3.9e-17 62.5 0.0 7.4e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK60059.1 - 2.1e-05 24.6 0.0 0.00038 20.6 0.0 2.6 2 0 0 2 2 2 1 H2C2 zinc finger DUF4441 PF14536.6 PIK60059.1 - 0.089 13.0 1.9 3.5 7.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) Sulfotransfer_2 PF03567.14 PIK60060.1 - 3.1e-33 115.7 0.1 1.4e-32 113.6 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase family zf-TRAF PF02176.18 PIK60061.1 - 6.8e-24 84.3 23.2 7e-18 65.1 7.8 2.8 3 0 0 3 3 3 2 TRAF-type zinc finger TRAF6_Z2 PF18048.1 PIK60061.1 - 0.00049 20.1 4.4 0.1 12.7 0.1 3.7 3 0 0 3 3 3 2 TNF receptor-associated factor 6 zinc finger 2 zf-TRAF_2 PF15965.5 PIK60061.1 - 0.0019 18.6 15.6 0.0037 17.7 7.2 3.0 1 1 2 3 3 3 2 TRAF-like zinc-finger Pkinase_Tyr PF07714.17 PIK60062.1 - 6.5e-17 61.7 0.0 8.2e-17 61.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60062.1 - 0.04 13.3 0.0 0.067 12.5 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain EZH2_N PF18601.1 PIK60062.1 - 0.16 12.4 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 EZH2 N-terminal domain Ig_3 PF13927.6 PIK60063.1 - 2.5e-05 24.8 1.4 7.8e-05 23.2 0.1 2.3 2 1 1 3 3 3 1 Immunoglobulin domain ig PF00047.25 PIK60063.1 - 5.8e-05 23.2 2.1 0.00031 20.8 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK60063.1 - 0.017 15.2 0.2 0.11 12.6 0.1 2.4 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK60063.1 - 0.021 15.2 1.0 0.13 12.6 0.2 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Sulfotransfer_2 PF03567.14 PIK60064.1 - 3.4e-12 46.8 0.2 7.6e-12 45.7 0.2 1.6 1 0 0 1 1 1 1 Sulfotransferase family Ig_2 PF13895.6 PIK60064.1 - 2.6e-09 37.3 0.6 0.0038 17.5 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK60064.1 - 9.4e-09 35.4 0.1 4.4e-07 30.0 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK60064.1 - 1.3e-08 35.3 0.4 0.00025 21.6 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK60064.1 - 2.5e-07 30.7 0.1 0.00021 21.3 0.0 3.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain Kinesin PF00225.23 PIK60064.1 - 1.1e-06 27.8 1.4 2.3e-06 26.8 1.4 1.5 1 1 0 1 1 1 1 Kinesin motor domain ig PF00047.25 PIK60064.1 - 4.9e-06 26.6 1.7 0.052 13.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain SIT PF15330.6 PIK60064.1 - 0.0043 17.5 0.1 0.0097 16.3 0.1 1.6 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT Microtub_bd PF16796.5 PIK60064.1 - 0.013 15.4 0.1 0.044 13.7 0.1 1.9 1 0 0 1 1 1 0 Microtubule binding TMEM154 PF15102.6 PIK60064.1 - 0.017 15.1 0.1 0.095 12.6 0.1 2.3 1 0 0 1 1 1 0 TMEM154 protein family Sulfotransfer_1 PF00685.27 PIK60064.1 - 0.059 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase domain DUF1664 PF07889.12 PIK60064.1 - 0.062 13.3 0.0 0.25 11.4 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3792 PF12670.7 PIK60064.1 - 0.073 13.2 2.2 2.7 8.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) EphA2_TM PF14575.6 PIK60064.1 - 0.097 13.6 0.1 1.5 9.7 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF996 PF06195.13 PIK60064.1 - 0.1 12.9 1.7 0.3 11.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF996) C2-set_2 PF08205.12 PIK60064.1 - 0.11 12.6 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain OAD_gamma PF04277.13 PIK60064.1 - 1.1 9.9 3.2 2.3 8.9 0.1 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain FancD2 PF14631.6 PIK60065.1 - 5.7e-66 222.9 7.5 5.7e-66 222.9 7.5 2.1 2 0 0 2 2 2 1 Fanconi anaemia protein FancD2 nuclease EF-hand_8 PF13833.6 PIK60065.1 - 0.059 13.2 3.0 0.12 12.3 0.3 2.8 3 0 0 3 3 3 0 EF-hand domain pair FAST_2 PF08368.12 PIK60065.1 - 0.06 14.1 0.4 3.7 8.4 0.0 2.8 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 2 ResIII PF04851.15 PIK60066.1 - 1.5e-18 67.4 0.5 2.5e-18 66.7 0.5 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 PIK60066.1 - 3.4e-16 59.5 0.9 5.7e-16 58.8 0.9 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD_2 PF16739.5 PIK60066.1 - 5e-07 29.6 0.0 1.4e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Caspase recruitment domain AAA_22 PF13401.6 PIK60066.1 - 5e-06 26.8 0.1 1.6e-05 25.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK60066.1 - 0.00027 20.7 0.0 0.00048 19.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK60066.1 - 0.00087 19.6 2.7 0.0048 17.3 0.1 2.2 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 PIK60066.1 - 0.013 15.3 0.1 0.041 13.6 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 PIK60066.1 - 0.034 13.6 0.2 0.64 9.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_34 PF13872.6 PIK60066.1 - 0.049 12.5 0.4 0.18 10.6 0.4 1.8 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 PhoH PF02562.16 PIK60066.1 - 0.074 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 PIK60066.1 - 0.1 12.1 0.1 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 PIK60066.1 - 0.15 12.5 0.4 0.51 10.8 0.2 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RIG-I_C PF18119.1 PIK60067.1 - 5.2e-23 81.6 0.4 1.3e-22 80.3 0.4 1.7 1 0 0 1 1 1 1 RIG-I receptor C-terminal domain Helicase_C PF00271.31 PIK60067.1 - 4.8e-13 49.4 0.0 1.6e-12 47.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK60067.1 - 6.3e-08 32.6 0.2 1.8e-07 31.1 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK60067.1 - 7.4e-07 29.3 0.1 2.5e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CARD_2 PF16739.5 PIK60067.1 - 5.7e-05 23.0 0.0 0.0013 18.6 0.0 2.8 2 0 0 2 2 2 1 Caspase recruitment domain PHD PF00628.29 PIK60068.1 - 2.8e-05 23.9 10.4 7.6e-05 22.5 10.4 1.8 1 0 0 1 1 1 1 PHD-finger Peptidase_C48 PF02902.19 PIK60068.1 - 0.00015 21.7 0.1 0.0015 18.4 0.5 2.5 3 1 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain Acetyltransf_14 PF03421.16 PIK60068.1 - 0.00017 21.7 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 YopJ Serine/Threonine acetyltransferase Zn_Tnp_IS91 PF14319.6 PIK60068.1 - 1.1 9.3 8.7 0.86 9.7 6.6 1.8 2 0 0 2 2 2 0 Transposase zinc-binding domain Rho_N PF07498.12 PIK60069.1 - 0.046 13.7 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain MUG113 PF13455.6 PIK60071.1 - 0.0065 17.1 2.0 1.2 9.8 0.2 2.8 2 1 0 2 2 2 2 Meiotically up-regulated gene 113 NPV_P10 PF05531.12 PIK60071.1 - 1.6 9.2 8.3 3.1 8.3 0.2 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TolA_bind_tri PF16331.5 PIK60071.1 - 2 8.6 26.8 7.2 6.8 0.2 3.6 3 0 0 3 3 3 0 TolA binding protein trimerisation WD40 PF00400.32 PIK60072.1 - 0.0091 16.8 0.6 0.09 13.7 0.0 2.9 4 1 0 4 4 4 1 WD domain, G-beta repeat DUF370 PF04025.12 PIK60072.1 - 0.068 13.3 0.0 0.3 11.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF370) GSAP-16 PF14959.6 PIK60074.1 - 5.9e-08 32.6 1.3 1.3e-06 28.2 0.2 3.2 3 1 0 3 3 3 1 gamma-Secretase-activating protein C-term SBF PF01758.16 PIK60075.1 - 1.6e-19 70.3 15.3 3.3e-19 69.3 15.3 1.5 1 0 0 1 1 1 1 Sodium Bile acid symporter family Mem_trans PF03547.18 PIK60075.1 - 5.3 5.3 15.3 6.6 5.0 6.7 2.5 1 1 1 2 2 2 0 Membrane transport protein CD52 PF15116.6 PIK60077.1 - 0.098 12.7 2.6 0.26 11.4 2.6 1.7 1 0 0 1 1 1 0 CAMPATH-1 antigen Pkinase PF00069.25 PIK60078.1 - 9.6e-42 143.2 0.0 6e-34 117.6 0.0 3.3 3 1 1 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60078.1 - 5.5e-31 107.8 1.5 3.9e-24 85.4 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase OSR1_C PF12202.8 PIK60078.1 - 3e-26 91.4 1.8 3e-26 91.4 1.8 2.2 2 0 0 2 2 2 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_fungal PF17667.1 PIK60078.1 - 0.0067 15.2 0.0 0.0067 15.2 0.0 2.5 2 1 0 2 2 2 1 Fungal protein kinase DUF2034 PF10356.9 PIK60078.1 - 0.074 12.5 1.0 0.17 11.3 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) BSP_II PF05432.11 PIK60078.1 - 1.2 8.8 23.6 0.027 14.2 16.6 1.8 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PDZ PF00595.24 PIK60079.1 - 5.4e-11 42.7 0.0 1.1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK60079.1 - 6.9e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK60079.1 - 0.00014 22.1 0.0 0.00024 21.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK60080.1 - 8.3e-12 45.3 0.1 1.3e-11 44.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK60080.1 - 3.8e-09 36.3 0.1 6.8e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK60080.1 - 0.0031 17.8 0.0 0.0047 17.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK60081.1 - 4.4e-25 87.3 0.3 6.1e-13 48.4 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 PIK60081.1 - 2.8e-24 85.3 0.0 6.7e-11 42.4 0.0 2.1 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK60081.1 - 1.8e-11 44.2 0.0 4.4e-05 23.7 0.1 2.2 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 PIK60081.1 - 0.00073 19.5 0.1 0.11 12.5 0.0 2.3 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ PF00595.24 PIK60082.1 - 4.1e-42 142.4 2.4 2.6e-14 53.3 0.3 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 PIK60082.1 - 1.8e-30 104.6 0.6 3.4e-09 36.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 PIK60082.1 - 2.3e-16 59.8 0.3 4.8e-06 26.8 0.0 3.2 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 PIK60082.1 - 1.5e-05 24.9 0.1 0.16 11.9 0.0 3.4 3 0 0 3 3 3 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 PIK60082.1 - 0.032 14.6 0.0 7 7.1 0.0 2.8 3 0 0 3 3 3 0 PDZ domain PikAIV_N PF18605.1 PIK60083.1 - 0.017 14.7 1.7 0.034 13.7 1.7 1.5 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Cep57_CLD_2 PF14197.6 PIK60083.1 - 0.082 13.0 2.9 0.14 12.2 2.9 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 NRBF2 PF08961.10 PIK60083.1 - 0.35 10.5 2.8 0.78 9.3 2.8 1.5 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator WD40 PF00400.32 PIK60084.1 - 5.7e-06 27.0 1.0 0.064 14.2 1.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK60084.1 - 0.095 11.6 0.0 0.17 10.8 0.0 1.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 PIK60084.1 - 0.15 12.4 0.0 0.54 10.6 0.0 1.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2 PF00096.26 PIK60085.1 - 4.1e-24 83.6 47.7 2.4e-06 27.7 4.0 5.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK60085.1 - 1.4e-22 79.0 44.5 6.3e-05 23.2 6.1 6.1 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK60085.1 - 6.2e-19 67.1 42.7 0.00046 20.8 3.2 5.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK60085.1 - 4.5e-09 36.1 39.3 0.00039 20.3 3.9 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK60085.1 - 1.3e-08 34.9 32.4 0.037 14.3 0.7 5.4 5 0 0 5 5 5 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK60085.1 - 8.6e-05 22.8 29.0 0.033 14.6 0.4 5.4 5 0 0 5 5 5 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 PIK60085.1 - 0.00044 20.3 17.6 0.14 12.3 1.7 3.8 3 2 0 3 3 3 2 Zinc ribbon domain XPA_N PF01286.18 PIK60085.1 - 0.0052 16.8 18.3 0.51 10.4 0.1 5.3 5 0 0 5 5 5 1 XPA protein N-terminal Zf_RING PF16744.5 PIK60085.1 - 0.0075 16.4 19.2 0.14 12.2 0.8 4.6 1 1 4 5 5 5 2 KIAA1045 RING finger FYDLN_acid PF09538.10 PIK60085.1 - 0.02 15.5 7.7 11 6.8 1.3 4.0 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) zf-AN1 PF01428.16 PIK60085.1 - 0.028 14.6 28.8 0.13 12.4 2.2 5.2 4 1 1 5 5 5 0 AN1-like Zinc finger zf-Sec23_Sec24 PF04810.15 PIK60085.1 - 0.032 14.3 16.4 1.9 8.6 2.5 4.8 3 2 1 4 4 4 0 Sec23/Sec24 zinc finger zf-C2H2_11 PF16622.5 PIK60085.1 - 0.055 13.2 0.3 0.055 13.2 0.3 4.3 5 0 0 5 5 4 0 zinc-finger C2H2-type BolA PF01722.18 PIK60085.1 - 0.062 13.6 4.2 5.8 7.3 0.8 3.3 2 2 1 4 4 4 0 BolA-like protein zf-MYST PF17772.1 PIK60085.1 - 0.14 11.8 16.5 0.34 10.6 0.2 4.5 2 1 3 5 5 5 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 PIK60085.1 - 0.14 12.9 18.1 0.86 10.4 1.7 3.2 1 1 3 4 4 4 0 zinc-ribbon family zf-C2HE PF16278.5 PIK60085.1 - 0.22 12.0 31.1 1.4 9.5 3.6 4.5 2 2 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2180 PF09947.9 PIK60085.1 - 0.23 11.5 0.0 0.23 11.5 0.0 3.9 3 2 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) FYVE PF01363.21 PIK60085.1 - 0.24 11.6 29.6 0.049 13.8 8.0 3.6 1 1 1 2 2 1 0 FYVE zinc finger Rep_fac-A_C PF08646.10 PIK60085.1 - 0.31 10.8 11.3 1.3 8.8 1.2 2.7 1 1 0 2 2 2 0 Replication factor-A C terminal domain zf-C2H2_9 PF16293.5 PIK60085.1 - 0.53 10.2 10.7 27 4.7 0.2 4.1 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) ADK_lid PF05191.14 PIK60085.1 - 0.65 10.0 18.7 1.4 9.0 1.2 3.8 2 2 1 3 3 3 0 Adenylate kinase, active site lid zf-C2H2_2 PF12756.7 PIK60085.1 - 0.71 10.2 28.6 3.4 8.1 1.3 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.6 PIK60085.1 - 1.3 9.0 21.6 2.1 8.3 0.2 5.1 4 1 0 4 4 4 0 Probable zinc-ribbon domain GAGA PF09237.11 PIK60085.1 - 1.5 8.7 12.3 0.68 9.8 0.2 3.7 1 1 2 4 4 4 0 GAGA factor zf_UBZ PF18439.1 PIK60085.1 - 2 8.0 17.3 12 5.5 0.3 5.2 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_9 PF14369.6 PIK60085.1 - 4.1 7.7 16.6 7.4 6.9 2.5 4.5 4 1 1 5 5 5 0 zinc-ribbon Cript PF10235.9 PIK60085.1 - 5.5 7.6 24.9 1.8 9.2 3.7 3.9 1 1 2 3 3 3 0 Microtubule-associated protein CRIPT Zn_ribbon_SprT PF17283.2 PIK60085.1 - 7.7 6.5 21.3 3.2 7.7 2.6 4.5 3 2 1 4 4 4 0 SprT-like zinc ribbon domain DUF2256 PF10013.9 PIK60085.1 - 9.8 6.4 17.6 73 3.6 0.0 5.2 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) RPN7 PF10602.9 PIK60086.1 - 2.3e-61 206.5 3.4 3.3e-61 206.0 3.4 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 PIK60086.1 - 6.6e-17 61.9 0.0 1.8e-16 60.5 0.0 1.8 1 0 0 1 1 1 1 PCI domain DUF2779 PF11074.8 PIK60086.1 - 0.0077 16.7 0.5 0.15 12.6 0.1 2.8 3 1 0 3 3 3 1 Domain of unknown function(DUF2779) UQ_con PF00179.26 PIK60087.1 - 1.2e-46 157.9 0.0 1.4e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK60087.1 - 0.0018 18.0 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 PIK60087.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.4 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 PIK60087.1 - 0.075 13.3 0.1 0.11 12.7 0.1 1.4 1 1 0 1 1 1 0 RWD domain DUF2457 PF10446.9 PIK60088.1 - 0.16 11.1 24.5 0.17 11.0 24.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PTPRCAP PF15713.5 PIK60088.1 - 0.2 11.9 12.8 0.25 11.6 12.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 PIK60088.1 - 1.6 6.9 19.6 1.7 6.8 19.6 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK60088.1 - 3.9 6.8 21.0 4 6.8 21.0 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 PIK60088.1 - 5 6.4 21.2 5.4 6.2 21.2 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 PIK60088.1 - 7.5 4.7 14.0 8.4 4.6 14.0 1.1 1 0 0 1 1 1 0 CDC45-like protein IFT57 PF10498.9 PIK60088.1 - 9.6 5.1 8.1 12 4.8 8.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 LisH PF08513.11 PIK60089.1 - 9.9e-06 25.3 0.0 2.7e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 LisH Ribosomal_L22e PF01776.17 PIK60089.1 - 0.061 13.7 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L22e protein family Macoilin PF09726.9 PIK60089.1 - 3.2 6.2 18.6 4.8 5.6 18.6 1.2 1 0 0 1 1 1 0 Macoilin family CECR6_TMEM121 PF14997.6 PIK60090.1 - 9e-34 117.0 16.0 1.5e-33 116.3 16.0 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family FUN14 PF04930.15 PIK60090.1 - 0.0032 17.8 0.0 0.0062 16.9 0.0 1.6 1 1 0 1 1 1 1 FUN14 family DUF4131 PF13567.6 PIK60090.1 - 5.4 6.6 6.9 9.3 5.9 1.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) CECR6_TMEM121 PF14997.6 PIK60091.1 - 6.5e-35 120.8 14.1 6.5e-35 120.8 14.1 1.4 2 0 0 2 2 2 1 CECR6/TMEM121 family Glyco_transf_10 PF00852.19 PIK60092.1 - 1.8e-45 154.8 0.8 3.1e-45 154.1 0.8 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK60092.1 - 2e-11 44.3 0.1 4.4e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal HgmA PF04209.13 PIK60092.1 - 0.016 14.0 0.0 0.026 13.2 0.0 1.3 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase Leader_CPA1 PF08252.11 PIK60092.1 - 0.42 10.0 3.8 1.9 7.9 0.0 3.0 3 0 0 3 3 3 0 arg-2/CPA1 leader peptide WD40 PF00400.32 PIK60093.1 - 9.1e-20 70.6 21.4 0.0017 19.1 0.3 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60093.1 - 2.8e-08 34.0 9.2 0.0025 18.1 0.3 4.3 2 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK60093.1 - 0.021 13.8 3.8 2.1 7.2 0.0 3.5 2 2 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Laminin_G_2 PF02210.24 PIK60094.1 - 1.1e-32 113.2 0.0 3e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain GAIN PF16489.5 PIK60094.1 - 1.2e-30 106.5 0.3 2.5e-30 105.5 0.3 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.24 PIK60094.1 - 1.3e-28 99.9 24.1 1.9e-27 96.1 16.1 2.3 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) Laminin_G_1 PF00054.23 PIK60094.1 - 3.7e-25 88.7 0.2 5.8e-16 58.9 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain GPS PF01825.21 PIK60094.1 - 7e-15 55.3 4.9 7e-15 55.3 4.9 3.6 3 0 0 3 3 2 1 GPCR proteolysis site, GPS, motif Laminin_EGF PF00053.24 PIK60094.1 - 1.9e-08 34.3 83.9 4.9e-08 33.0 14.0 7.3 6 1 1 7 7 7 4 Laminin EGF domain HRM PF02793.22 PIK60094.1 - 2.4e-08 34.2 2.5 2.4e-08 34.2 2.5 4.6 6 1 0 6 6 5 1 Hormone receptor domain EGF PF00008.27 PIK60094.1 - 2.2e-07 31.0 6.3 2.2e-07 31.0 6.3 7.6 7 0 0 7 7 5 4 EGF-like domain Laminin_G_3 PF13385.6 PIK60094.1 - 0.00098 19.3 0.8 0.14 12.3 0.0 2.4 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DTHCT PF08070.11 PIK60094.1 - 0.013 16.2 4.0 0.029 15.1 4.0 1.5 1 0 0 1 1 1 0 DTHCT (NUC029) region hEGF PF12661.7 PIK60094.1 - 2.3 9.0 41.6 0.086 13.5 3.7 7.4 7 0 0 7 7 7 0 Human growth factor-like EGF Cadherin PF00028.17 PIK60095.1 - 1.7e-38 131.0 1.2 1.7e-19 70.0 0.2 3.1 3 0 0 3 3 3 3 Cadherin domain Cadherin_2 PF08266.12 PIK60095.1 - 0.0061 16.4 0.0 21 5.0 0.0 3.3 3 0 0 3 3 3 3 Cadherin-like Cadherin PF00028.17 PIK60096.1 - 1.9e-123 403.2 22.4 6.5e-23 81.0 0.1 7.0 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 PIK60096.1 - 1.6e-08 34.3 0.0 0.39 10.6 0.0 6.1 5 1 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.5 PIK60096.1 - 1.5e-07 31.4 17.7 0.034 14.1 0.3 6.4 7 0 0 7 7 7 3 Cadherin-like RET_CLD1 PF17756.1 PIK60096.1 - 1.7e-07 31.5 0.0 1.7 9.0 0.0 5.2 5 1 0 6 6 6 2 RET Cadherin like domain 1 PepSY PF03413.19 PIK60096.1 - 9.4e-05 22.9 5.2 8.6 7.0 0.0 6.2 6 1 1 7 7 7 2 Peptidase propeptide and YPEB domain DUF5419 PF17441.2 PIK60096.1 - 0.0031 17.6 0.0 0.03 14.4 0.0 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5419) Fibrinogen_C PF00147.18 PIK60098.1 - 7.4e-41 140.4 2.7 9.1e-41 140.1 2.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Peptidase_S66 PF02016.15 PIK60099.1 - 0.023 14.8 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Fibrinogen_C PF00147.18 PIK60100.1 - 3.5e-71 239.5 14.1 1.4e-57 195.1 9.1 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain T3SS_basalb_I PF17001.5 PIK60102.1 - 0.038 14.6 0.1 0.057 14.0 0.1 1.2 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI RNase_T PF00929.24 PIK60104.1 - 9e-19 68.6 0.0 1.5e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 PIK60104.1 - 0.018 14.8 0.0 0.073 12.8 0.0 1.9 1 1 0 1 1 1 0 3'-5' exonuclease Ribosomal_S9 PF00380.19 PIK60105.1 - 0.0068 16.9 2.2 0.0068 16.9 2.2 2.2 3 0 0 3 3 3 1 Ribosomal protein S9/S16 SLM4 PF16818.5 PIK60105.1 - 0.11 12.4 4.7 2.8 7.9 1.1 2.4 1 1 0 2 2 2 0 Protein SLM4 DUF4806 PF16064.5 PIK60106.1 - 0.002 18.4 0.1 38 4.7 0.0 3.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4806) Cytochrom_C1 PF02167.15 PIK60106.1 - 0.0026 17.5 2.3 0.07 12.9 0.1 2.9 1 1 3 4 4 4 1 Cytochrome C1 family DUF3472 PF11958.8 PIK60106.1 - 0.0081 16.6 1.5 32 4.9 0.0 4.2 2 1 3 5 5 5 0 Domain of unknown function (DUF3472) RPGR1_C PF18111.1 PIK60106.1 - 0.047 13.6 1.1 76 3.2 0.1 4.4 1 1 3 4 4 4 0 Retinitis pigmentosa G-protein regulator interacting C-terminal Borealin PF10512.9 PIK60106.1 - 0.063 13.3 0.0 47 4.0 0.0 3.9 1 1 4 5 5 5 0 Cell division cycle-associated protein 8 Glyphos_transf PF04464.14 PIK60106.1 - 3.8 6.4 39.6 1.6 7.6 0.1 6.5 7 0 0 7 7 7 0 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase Q_salvage PF10343.9 PIK60108.1 - 4.1e-120 400.6 0.1 5.3e-120 400.2 0.1 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 PIK60108.1 - 0.038 12.7 0.0 5.4 5.6 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1688) DNA_ligase_IV PF11411.8 PIK60108.1 - 0.04 14.0 0.0 0.093 12.9 0.0 1.7 1 0 0 1 1 1 0 DNA ligase IV HDNR PF15115.6 PIK60109.1 - 2.6e-22 79.9 8.4 4e-22 79.3 8.4 1.3 1 0 0 1 1 1 1 Domain of unknown function with conserved HDNR motif His_Phos_1 PF00300.22 PIK60111.1 - 1.2e-34 119.7 0.0 1.6e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TetR_C_13 PF16925.5 PIK60111.1 - 0.076 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Acetyltransf_1 PF00583.25 PIK60112.1 - 1.3e-07 31.8 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 PIK60112.1 - 0.00099 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 PIK60112.1 - 0.0029 17.5 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PI3Ka PF00613.20 PIK60112.1 - 0.015 14.7 0.1 0.032 13.7 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Acetyltransf_7 PF13508.7 PIK60112.1 - 0.06 13.8 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_17 PF17668.1 PIK60112.1 - 0.14 12.9 0.0 0.24 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AMP-binding PF00501.28 PIK60113.1 - 1.2e-35 123.0 0.0 1.6e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK60113.1 - 7.1e-22 78.2 1.0 1.2e-21 77.4 1.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK60114.1 - 1.4e-09 37.1 0.1 1.4e-09 37.0 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme zf-C2H2 PF00096.26 PIK60115.1 - 2.8e-09 36.9 19.4 0.00038 20.7 3.0 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60115.1 - 4.1e-09 36.5 16.9 0.0014 19.3 1.8 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK60115.1 - 0.00021 21.5 1.9 0.00021 21.5 1.9 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK60115.1 - 0.076 13.3 9.2 0.91 9.9 3.4 2.8 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF2256 PF10013.9 PIK60115.1 - 0.084 13.0 4.5 3.3 7.9 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-CHCC PF10276.9 PIK60115.1 - 0.092 12.8 10.3 0.35 11.0 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger domain DZR PF12773.7 PIK60115.1 - 0.17 11.9 5.1 2.4 8.3 5.1 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-C2HC_2 PF13913.6 PIK60115.1 - 0.17 11.8 11.9 1.3 9.0 0.8 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DUF4187 PF13821.6 PIK60115.1 - 0.18 11.6 10.1 0.72 9.7 0.6 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4187) zf-BED PF02892.15 PIK60115.1 - 0.22 11.6 16.5 1.1 9.3 1.6 3.4 1 1 2 3 3 3 0 BED zinc finger CpXC PF14353.6 PIK60115.1 - 0.22 11.5 6.4 5.2 7.1 0.2 2.9 1 1 1 2 2 2 0 CpXC protein FBP_C PF16571.5 PIK60115.1 - 0.27 10.7 2.1 0.35 10.4 0.5 1.9 1 1 1 2 2 2 0 FBP C-terminal treble-clef zinc-finger PyrI_C PF02748.15 PIK60115.1 - 0.48 10.4 10.6 3 7.8 1.9 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 PIK60115.1 - 0.68 10.3 13.0 2.1 8.8 0.6 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 PIK60115.1 - 0.77 10.3 21.7 0.29 11.7 2.4 4.4 4 1 0 4 4 4 0 Zinc-finger double domain zf-ribbon_3 PF13248.6 PIK60115.1 - 0.81 9.2 5.8 8.7 5.9 0.2 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 PIK60115.1 - 0.85 9.8 5.3 2.4 8.3 2.6 2.4 1 1 1 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 PIK60115.1 - 1 8.9 3.6 6.8 6.3 0.7 2.5 1 1 1 2 2 2 0 TFIIB zinc-binding HNH PF01844.23 PIK60115.1 - 1.1 9.5 9.3 2.7 8.2 0.4 3.1 4 0 0 4 4 3 0 HNH endonuclease zinc_ribbon_15 PF17032.5 PIK60115.1 - 2.4 8.9 7.2 18 6.2 4.3 2.5 1 1 1 2 2 2 0 zinc-ribbon family Vasohibin PF14822.6 PIK60116.1 - 1.5e-13 50.6 0.0 1.7e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Vasohibin Opacity PF02462.15 PIK60117.1 - 0.035 14.2 0.0 0.047 13.8 0.0 1.2 1 0 0 1 1 1 0 Opacity family porin protein Ins134_P3_kin PF05770.11 PIK60119.1 - 1.1e-54 185.0 0.1 1.8e-54 184.3 0.1 1.3 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 PIK60119.1 - 7.3e-14 51.9 0.2 1.4e-13 51.0 0.2 1.5 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Dala_Dala_lig_C PF07478.13 PIK60119.1 - 0.063 12.8 0.2 3.4 7.1 0.1 2.2 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus DUF5582 PF17819.1 PIK60119.1 - 0.14 12.6 1.3 0.22 11.9 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5582) DUF883 PF05957.13 PIK60119.1 - 0.22 12.2 0.6 2.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) AAA PF00004.29 PIK60120.1 - 8.6e-43 145.9 0.0 1.6e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK60120.1 - 1.3e-10 40.9 0.4 2.4e-10 40.1 0.4 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 PIK60120.1 - 2e-09 37.2 0.2 3.9e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 PIK60120.1 - 2.6e-07 30.9 0.0 5.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK60120.1 - 4.6e-06 27.0 0.1 0.0019 18.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 PIK60120.1 - 3.9e-05 22.9 0.0 6.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 PIK60120.1 - 4.9e-05 23.1 0.0 9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK60120.1 - 0.0001 22.7 0.1 0.0033 17.8 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 PIK60120.1 - 0.00012 22.1 0.2 0.00059 19.9 0.2 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK60120.1 - 0.0028 17.4 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 PIK60120.1 - 0.004 17.3 0.0 0.0082 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK60120.1 - 0.0046 16.3 0.2 0.37 10.1 0.0 2.6 2 1 0 3 3 3 1 KaiC AAA_28 PF13521.6 PIK60120.1 - 0.0061 16.8 0.4 0.014 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK60120.1 - 0.0065 16.8 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 PIK60120.1 - 0.0078 15.8 0.3 0.35 10.4 0.1 2.4 1 1 1 2 2 2 1 AAA domain Prot_ATP_OB_N PF17758.1 PIK60120.1 - 0.0093 15.6 0.1 0.033 13.8 0.0 2.0 2 0 0 2 2 1 1 Proteasomal ATPase OB N-terminal domain AAA_18 PF13238.6 PIK60120.1 - 0.013 16.0 0.0 0.013 16.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 PIK60120.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain PhoH PF02562.16 PIK60120.1 - 0.016 14.6 0.0 0.082 12.4 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 PIK60120.1 - 0.017 14.6 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 PIK60120.1 - 0.017 15.2 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 PIK60120.1 - 0.031 14.2 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 PIK60120.1 - 0.04 13.7 0.5 0.096 12.4 0.2 1.8 2 1 0 2 2 1 0 AAA domain NACHT PF05729.12 PIK60120.1 - 0.047 13.6 0.0 0.59 10.0 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 PIK60120.1 - 0.047 13.2 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 PIK60120.1 - 0.069 12.9 0.2 0.15 11.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 PIK60120.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 PIK60120.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 PIK60120.1 - 0.15 12.6 0.0 0.46 11.0 0.0 1.9 2 0 0 2 2 1 0 ABC transporter Sigma54_activat PF00158.26 PIK60120.1 - 0.17 11.6 0.1 0.61 9.8 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 PIK60120.1 - 0.17 11.6 0.6 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain PAP_central PF04928.17 PIK60121.1 - 9.6e-111 368.7 0.0 1.8e-110 367.8 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 PIK60121.1 - 5.5e-10 39.4 0.0 1.6e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_RNA-bind PF04926.15 PIK60121.1 - 7.7e-10 38.7 0.9 1.7e-09 37.6 0.8 1.6 1 1 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain DDE_Tnp_1_7 PF13843.6 PIK60122.1 - 1.1e-34 120.3 0.0 1.3e-34 120.1 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 rve PF00665.26 PIK60123.1 - 4.1e-20 72.2 0.0 8.5e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60123.1 - 1.2e-17 63.7 0.7 2.3e-17 62.8 0.7 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK60123.1 - 0.0012 18.6 0.0 0.003 17.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK60123.1 - 0.0012 19.0 1.3 0.0024 18.1 0.2 2.1 2 0 0 2 2 2 1 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK60123.1 - 0.082 13.1 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 DDE domain DUF4042 PF13251.6 PIK60123.1 - 0.14 11.8 0.0 0.91 9.2 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) RVT_1 PF00078.27 PIK60124.1 - 5.5e-29 101.3 0.0 1e-28 100.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK60124.1 - 1.3e-22 79.7 0.0 3e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60124.1 - 5.6e-13 49.1 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVP PF00077.20 PIK60124.1 - 0.011 16.0 0.0 0.037 14.3 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK60124.1 - 0.011 16.2 0.0 0.031 14.8 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_thumb PF06817.14 PIK60124.1 - 0.035 13.9 0.0 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase thumb domain Asp_protease_2 PF13650.6 PIK60124.1 - 0.1 13.2 0.0 0.42 11.3 0.0 2.1 2 0 0 2 2 2 0 Aspartyl protease Seipin PF06775.14 PIK60125.1 - 1.3e-54 185.3 1.4 1.6e-54 185.0 1.4 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) NETI PF14044.6 PIK60125.1 - 0.17 11.7 0.1 0.38 10.5 0.1 1.5 1 0 0 1 1 1 0 NETI protein Ank_2 PF12796.7 PIK60126.1 - 7.7e-28 96.9 3.0 1.2e-11 45.0 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 PIK60126.1 - 4.6e-23 80.6 0.5 0.00059 20.2 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 PIK60126.1 - 2.3e-21 75.9 0.3 8.4e-07 29.4 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK60126.1 - 1.1e-16 60.7 1.3 4.4e-07 30.0 0.6 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK60126.1 - 8.1e-14 50.4 0.2 0.0052 17.2 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat HAP1_N PF04849.13 PIK60127.1 - 0.0038 16.5 1.1 0.0056 15.9 1.1 1.4 1 0 0 1 1 1 1 HAP1 N-terminal conserved region TSNAXIP1_N PF15739.5 PIK60127.1 - 0.0069 16.8 1.3 0.024 15.0 1.3 1.9 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus Med9 PF07544.13 PIK60127.1 - 0.031 14.3 2.2 0.059 13.5 0.4 2.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 PLDc_N PF13396.6 PIK60127.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal AATF-Che1 PF13339.6 PIK60127.1 - 0.74 10.5 4.5 1.7 9.3 3.3 2.3 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor TSNAXIP1_N PF15739.5 PIK60128.1 - 0.00024 21.5 1.0 0.00048 20.5 1.0 1.4 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus HAP1_N PF04849.13 PIK60128.1 - 0.013 14.7 1.3 0.019 14.2 1.3 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region CABIT PF12736.7 PIK60129.1 - 0.013 14.8 1.7 0.014 14.7 0.0 1.8 2 1 0 2 2 2 0 Cell-cycle sustaining, positive selection, Methyltransf_11 PF08241.12 PIK60132.1 - 0.016 15.8 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 PIK60132.1 - 0.11 12.3 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain zf-CCHC PF00098.23 PIK60133.1 - 1.1e-07 31.6 1.9 2.1e-07 30.7 1.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK60133.1 - 0.00032 20.5 0.1 0.00032 20.5 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK60133.1 - 0.12 12.2 0.4 0.19 11.5 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK60133.1 - 0.16 12.1 0.3 0.4 10.8 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK60133.1 - 0.21 11.4 0.5 0.45 10.3 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle HscB_4_cys PF18256.1 PIK60133.1 - 8.2 6.3 5.9 1 9.2 1.1 2.0 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Asp_protease PF09668.10 PIK60134.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH_2 PF17919.1 PIK60135.1 - 1.4e-37 127.8 0.1 2.3e-37 127.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60135.1 - 2.3e-33 114.6 0.0 4.3e-33 113.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60135.1 - 1.6e-31 109.6 0.0 2.6e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK60135.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase rve PF00665.26 PIK60136.1 - 3.8e-24 85.1 0.0 5.5e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60136.1 - 6.2e-11 42.2 0.9 1.2e-10 41.3 0.9 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK60136.1 - 0.0029 17.8 0.9 0.006 16.8 0.9 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK60136.1 - 0.0033 17.2 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK60136.1 - 0.011 16.2 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal DUF5382 PF17354.2 PIK60136.1 - 0.056 12.3 0.0 0.1 11.4 0.0 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5382) QueC PF06508.13 PIK60136.1 - 0.12 11.8 0.6 0.23 11.0 0.6 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC adh_short PF00106.25 PIK60137.1 - 1.9e-25 89.5 2.8 2.5e-25 89.1 2.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK60137.1 - 4.1e-24 85.4 1.5 5.6e-24 85.0 1.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK60137.1 - 4.5e-09 36.5 1.1 6.2e-09 36.0 1.1 1.1 1 0 0 1 1 1 1 KR domain PALP PF00291.25 PIK60137.1 - 0.007 15.8 0.1 0.0085 15.5 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme 3HCDH_N PF02737.18 PIK60137.1 - 0.033 14.1 0.5 0.043 13.7 0.5 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF2183 PF09949.9 PIK60138.1 - 0.12 12.7 0.0 11 6.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) Lipase_GDSL_2 PF13472.6 PIK60138.1 - 0.19 12.1 0.1 0.34 11.3 0.1 1.6 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Peptidase_M48_N PF16491.5 PIK60139.1 - 3e-68 229.3 7.4 3e-68 229.3 7.4 2.0 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 PIK60139.1 - 1.9e-60 204.0 0.0 2.8e-60 203.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF4710 PF15828.5 PIK60139.1 - 1.7 8.8 4.5 24 5.1 3.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) MPC PF03650.13 PIK60141.1 - 8.9e-40 135.3 0.1 1.2e-39 134.9 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers UPF0242 PF06785.11 PIK60141.1 - 0.039 14.1 0.0 0.048 13.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Pkinase PF00069.25 PIK60142.1 - 3.3e-51 174.2 0.0 3e-39 135.0 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60142.1 - 1.3e-28 100.0 0.0 6e-22 78.2 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PQQ PF01011.21 PIK60142.1 - 7.9e-09 35.0 0.2 0.035 14.0 0.0 3.7 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.6 PIK60142.1 - 1.2e-08 34.9 0.0 2.5e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 PQQ-like domain Kinase-like PF14531.6 PIK60142.1 - 5.4e-06 25.9 0.1 4.5e-05 22.9 0.1 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 PIK60142.1 - 2.6e-05 23.2 0.4 4.4e-05 22.4 0.4 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 PIK60142.1 - 0.02 14.2 0.1 0.046 13.1 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 PIK60142.1 - 0.057 13.0 0.1 6.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PQQ_3 PF13570.6 PIK60142.1 - 0.092 13.3 0.0 10 6.7 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain RIO1 PF01163.22 PIK60142.1 - 0.13 11.9 0.7 0.52 9.9 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Synaptonemal_3 PF15191.6 PIK60143.1 - 0.056 13.2 0.2 0.08 12.7 0.2 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 LRR_8 PF13855.6 PIK60144.1 - 5.2e-24 83.8 13.0 2.3e-13 49.7 3.8 3.0 2 1 1 3 3 3 2 Leucine rich repeat LRR_5 PF13306.6 PIK60144.1 - 1.3e-11 44.5 0.1 2.7e-11 43.5 0.1 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK60144.1 - 1.1e-09 38.4 23.7 9e-05 22.8 2.1 4.3 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK60144.1 - 7.4e-09 35.0 6.4 0.093 13.3 0.1 5.4 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.6 PIK60144.1 - 0.00011 21.9 10.5 0.13 12.4 0.1 4.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_9 PF14580.6 PIK60144.1 - 0.00012 21.6 0.7 0.0044 16.5 0.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat Ig_3 PF13927.6 PIK60144.1 - 0.00064 20.3 0.7 0.003 18.1 0.1 2.5 2 1 0 2 2 2 1 Immunoglobulin domain LRRNT PF01462.18 PIK60144.1 - 0.011 15.4 4.6 0.011 15.4 4.6 2.5 2 1 0 2 2 2 0 Leucine rich repeat N-terminal domain TPKR_C2 PF16920.5 PIK60144.1 - 0.02 15.0 2.2 0.075 13.2 0.7 2.8 3 0 0 3 3 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.25 PIK60144.1 - 0.037 14.2 1.7 0.068 13.4 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK60144.1 - 0.044 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK60144.1 - 0.072 13.2 0.1 0.23 11.6 0.1 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain 7tm_2 PF00002.24 PIK60145.1 - 1.1e-14 54.4 10.8 1.8e-14 53.6 10.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK60145.1 - 9.1e-11 42.1 0.0 2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TMEMspv1-c74-12 PF11044.8 PIK60145.1 - 0.004 17.1 1.5 0.0096 15.9 1.5 1.6 1 0 0 1 1 1 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein Adeno_E3_CR2 PF02439.15 PIK60145.1 - 0.019 14.7 3.4 0.019 14.7 3.4 2.9 4 0 0 4 4 4 0 Adenovirus E3 region protein CR2 Fez1 PF06818.15 PIK60146.1 - 3.5e-20 73.3 32.9 3.5e-20 73.3 32.9 4.2 1 1 1 3 3 3 2 Fez1 Pox_A_type_inc PF04508.12 PIK60146.1 - 0.88 9.5 23.2 1.1 9.3 0.0 7.2 6 1 1 7 7 7 0 Viral A-type inclusion protein repeat WBP-1 PF11669.8 PIK60147.1 - 2.5e-24 85.9 10.6 9.1e-24 84.1 10.6 2.0 1 1 0 1 1 1 1 WW domain-binding protein 1 Presenilin PF01080.17 PIK60148.1 - 4.7 5.9 8.3 4.7 5.9 8.3 1.0 1 0 0 1 1 1 0 Presenilin NIF PF03031.18 PIK60149.1 - 7.1e-30 103.8 0.2 1.6e-29 102.7 0.1 1.6 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 PIK60149.1 - 1.9e-08 34.0 0.2 4.9e-08 32.6 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin family DUF705 PF05152.12 PIK60149.1 - 0.018 14.6 0.1 0.029 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Ubiquitin_2 PF14560.6 PIK60149.1 - 0.12 12.9 0.2 0.32 11.5 0.2 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain Sec8_exocyst PF04048.14 PIK60150.1 - 9.9e-16 57.9 2.7 3.7e-15 56.1 2.7 2.1 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Zw10 PF06248.13 PIK60150.1 - 7.9e-05 21.4 10.8 0.00069 18.3 3.8 3.4 3 1 0 3 3 3 3 Centromere/kinetochore Zw10 COG5 PF10392.9 PIK60150.1 - 0.00054 20.2 1.2 0.00054 20.2 1.2 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps54_N PF10475.9 PIK60150.1 - 0.058 12.7 5.9 0.15 11.4 5.9 1.6 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex RT_RNaseH_2 PF17919.1 PIK60151.1 - 7.2e-24 83.7 0.0 1.6e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60151.1 - 2.2e-18 66.6 0.0 4.8e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK60151.1 - 7.2e-12 45.5 0.0 1.5e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVP PF00077.20 PIK60151.1 - 0.0023 18.2 0.0 0.0051 17.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK60151.1 - 0.004 17.2 3.6 0.011 15.7 3.6 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 PIK60151.1 - 0.0061 17.2 0.1 0.028 15.1 0.0 2.1 3 0 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK60151.1 - 0.0089 16.6 0.0 0.025 15.1 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease DNA_pol_viral_C PF00336.18 PIK60151.1 - 0.067 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain rve PF00665.26 PIK60152.1 - 4.7e-17 62.3 0.0 6.3e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK60152.1 - 4e-05 23.3 0.0 6.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK60152.1 - 0.0015 18.3 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-C2H2_6 PF13912.6 PIK60154.1 - 7.6e-06 25.8 0.4 7.6e-06 25.8 0.4 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 PIK60154.1 - 1.8e-05 25.2 15.8 0.00052 20.6 0.3 3.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK60154.1 - 0.00057 20.2 15.1 0.0022 18.4 0.5 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK60154.1 - 0.0025 18.2 15.0 0.033 14.6 0.8 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 PIK60154.1 - 0.0041 17.5 3.8 0.032 14.6 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK60154.1 - 0.034 14.4 2.9 0.14 12.4 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK60154.1 - 0.075 13.3 1.5 4.3 7.7 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 PIK60154.1 - 0.087 13.2 2.3 0.21 11.9 0.1 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 PIK60154.1 - 0.46 11.0 1.6 0.59 10.6 0.1 2.0 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 PIK60154.1 - 5.1 7.2 8.0 0.83 9.7 0.1 2.7 3 0 0 3 3 3 0 BED zinc finger LRR_4 PF12799.7 PIK60155.1 - 2.5e-16 59.5 8.8 8.4e-08 32.4 3.3 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK60155.1 - 9.6e-11 41.5 0.2 3.1e-06 26.8 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 PIK60155.1 - 1.9e-08 33.9 10.5 0.0015 18.2 1.9 3.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 PIK60155.1 - 0.0066 16.8 5.3 9.2 7.3 0.0 4.7 4 1 0 4 4 4 1 Leucine Rich Repeat Ribosomal_S10 PF00338.22 PIK60156.1 - 7.3e-19 67.8 0.1 1.1e-18 67.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Cwf_Cwc_15 PF04889.12 PIK60156.1 - 0.0076 16.0 9.2 0.0076 16.0 9.2 2.0 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein COG2 PF06148.11 PIK60157.1 - 1.2e-41 141.9 4.9 1.8e-41 141.3 2.7 2.3 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 PIK60157.1 - 5.2e-05 23.3 0.0 5.2e-05 23.3 0.0 2.7 4 0 0 4 4 4 1 Vps51/Vps67 GAS PF13851.6 PIK60157.1 - 0.016 14.5 6.3 0.032 13.6 6.3 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ApoA-II PF04711.13 PIK60157.1 - 0.064 13.4 0.8 0.55 10.4 0.0 2.8 3 0 0 3 3 3 0 Apolipoprotein A-II (ApoA-II) DUF1664 PF07889.12 PIK60157.1 - 0.11 12.6 4.9 0.26 11.3 1.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 PIK60157.1 - 1.2 9.5 5.4 1.7 9.0 2.8 2.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3510 PF12022.8 PIK60158.1 - 4.2e-37 127.3 0.6 5.2e-37 127.0 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) PspA_IM30 PF04012.12 PIK60158.1 - 0.035 13.7 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 PspA/IM30 family Gcd10p PF04189.13 PIK60159.1 - 2.2e-15 56.6 0.5 2.2e-15 56.6 0.5 2.0 1 1 1 2 2 2 1 Gcd10p family zf-DNA_Pol PF08996.10 PIK60159.1 - 0.092 12.5 0.7 0.21 11.3 0.7 1.6 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger Churchill PF06573.11 PIK60160.1 - 2.1e-44 150.4 9.1 2.3e-44 150.3 9.1 1.0 1 0 0 1 1 1 1 Churchill protein zf-3CxxC_2 PF17180.4 PIK60160.1 - 0.26 12.1 12.3 0.081 13.7 9.5 1.7 2 1 0 2 2 2 0 Zinc-binding domain zf-C4_ClpX PF06689.13 PIK60160.1 - 5.4 7.0 0.0 5.4 7.0 0.0 4.2 5 1 0 5 5 5 0 ClpX C4-type zinc finger Dimer_Tnp_hAT PF05699.14 PIK60161.1 - 2.2e-06 27.3 0.0 6.8e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.6 PIK60161.1 - 9.3e-05 22.2 0.1 0.00017 21.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK60161.1 - 0.0011 18.9 0.3 0.0038 17.1 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Imm74 PF15603.6 PIK60161.1 - 0.13 12.5 0.7 1.5 9.1 0.0 2.4 1 1 0 2 2 2 0 Immunity protein 74 Dak1 PF02733.17 PIK60162.1 - 2.4e-111 371.6 1.0 3e-111 371.3 1.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 PIK60162.1 - 1.4e-14 54.3 0.1 3e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 DAK2 domain PLDc_3 PF13918.6 PIK60163.1 - 3.6e-23 82.1 0.0 4.5e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 PIK60163.1 - 0.022 14.6 0.0 0.029 14.3 0.0 1.1 1 0 0 1 1 1 0 PLD-like domain LRR_4 PF12799.7 PIK60164.1 - 7.8e-05 23.0 0.1 0.44 11.0 0.0 2.2 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK60164.1 - 0.001 18.9 2.2 0.024 14.7 0.1 2.6 2 0 0 2 2 2 1 Leucine Rich repeat LRR_8 PF13855.6 PIK60164.1 - 0.0019 17.9 1.8 0.16 11.8 0.2 2.3 1 1 1 2 2 2 2 Leucine rich repeat Ion_trans_2 PF07885.16 PIK60165.1 - 2e-17 62.9 13.3 3.1e-14 52.7 8.3 2.4 2 1 0 2 2 2 2 Ion channel InaF-motif PF15018.6 PIK60165.1 - 0.069 13.0 4.3 0.069 13.0 4.3 3.0 3 0 0 3 3 3 0 TRP-interacting helix Ion_trans_2 PF07885.16 PIK60166.1 - 6.3e-30 103.0 13.3 8.9e-16 57.6 0.0 3.4 3 1 1 4 4 4 2 Ion channel Sigma_reg_N PF13800.6 PIK60166.1 - 0.13 12.6 4.6 1.9 8.8 0.3 3.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF3328 PF11807.8 PIK60166.1 - 0.19 11.5 1.6 1 9.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) PIG-U PF06728.13 PIK60166.1 - 0.41 9.6 7.7 0.88 8.5 0.7 2.7 2 1 1 3 3 3 0 GPI transamidase subunit PIG-U Internalin_N PF12354.8 PIK60166.1 - 1.8 8.7 6.1 13 5.9 0.1 2.9 3 0 0 3 3 3 0 Bacterial adhesion/invasion protein N terminal DUF2207 PF09972.9 PIK60166.1 - 7.7 5.1 5.6 2.3 6.9 2.7 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) LRR_4 PF12799.7 PIK60167.1 - 1.8e-17 63.2 30.4 7.8e-06 26.2 6.7 4.8 2 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK60167.1 - 1.2e-13 50.5 29.7 1.5e-05 24.6 9.5 3.9 1 1 3 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 PIK60167.1 - 8.3e-06 25.4 6.5 0.00027 20.5 3.4 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK60167.1 - 0.18 12.5 41.2 2.5 9.0 0.7 8.1 8 0 0 8 8 8 0 Leucine Rich Repeat Plus-3 PF03126.18 PIK60168.1 - 1.1e-33 116.0 0.4 4.1e-33 114.1 0.1 2.1 2 0 0 2 2 2 1 Plus-3 domain DUF1771 PF08590.10 PIK60168.1 - 0.00014 22.2 0.3 0.00033 21.0 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) PspA_IM30 PF04012.12 PIK60168.1 - 0.0062 16.1 4.5 0.015 14.9 4.5 1.7 1 1 0 1 1 1 1 PspA/IM30 family HSP70 PF00012.20 PIK60171.1 - 3.6e-42 144.4 0.2 4e-42 144.2 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein HSP70 PF00012.20 PIK60172.1 - 3.5e-36 124.6 0.2 3.9e-36 124.4 0.2 1.2 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 PIK60172.1 - 0.086 12.6 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Metallophos PF00149.28 PIK60173.1 - 3.5e-19 70.1 0.8 6e-19 69.3 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 PIK60173.1 - 6.3e-16 59.0 0.4 5.3e-15 56.0 0.0 2.4 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 PIK60173.1 - 4.8e-13 49.5 1.1 1.8e-12 47.7 0.4 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Cu_amine_oxidN2 PF02727.16 PIK60174.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain DUF4477 PF14780.6 PIK60178.1 - 4.4e-06 26.4 2.5 1.4e-05 24.8 0.4 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4477) HPS3_C PF14763.6 PIK60178.1 - 0.0013 18.2 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal COMMD1_N PF17221.3 PIK60180.1 - 5.9e-42 142.1 0.0 1e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 COMMD1 N-terminal domain COMM_domain PF07258.14 PIK60180.1 - 7.2e-14 51.7 1.2 1.5e-13 50.6 1.2 1.5 1 0 0 1 1 1 1 COMM domain SNO PF01174.19 PIK60180.1 - 0.012 15.5 0.1 0.83 9.5 0.1 2.0 2 0 0 2 2 2 0 SNO glutamine amidotransferase family Methyltransf_28 PF02636.17 PIK60182.1 - 1.5e-40 139.5 0.1 7.5e-40 137.2 0.1 1.8 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase FERM_M PF00373.18 PIK60183.1 - 8.8e-08 32.6 0.0 1.6e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 FERM central domain DUF4047 PF13256.6 PIK60183.1 - 0.19 11.9 0.2 0.38 11.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) p31comet PF06581.12 PIK60184.1 - 9.7e-15 54.4 0.0 7.3e-13 48.3 0.0 2.1 2 0 0 2 2 2 2 Mad1 and Cdc20-bound-Mad2 binding Nuc_deoxyrib_tr PF05014.15 PIK60185.1 - 5.8e-13 49.0 0.0 6.5e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Pkinase PF00069.25 PIK60186.1 - 1.7e-54 184.9 0.2 1.9e-54 184.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60186.1 - 1.4e-29 103.2 0.1 1.7e-29 102.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK60186.1 - 0.00015 21.2 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 PIK60186.1 - 0.0021 17.8 0.1 0.0034 17.0 0.1 1.5 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 PIK60186.1 - 0.0024 17.3 0.6 0.0051 16.2 0.6 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ribos_L4_asso_C PF14374.6 PIK60186.1 - 0.0048 16.9 0.0 0.0083 16.2 0.0 1.3 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain APH PF01636.23 PIK60186.1 - 0.028 14.3 0.2 0.15 12.0 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Acyltransf_C PF16076.5 PIK60187.1 - 3.1e-18 65.6 0.5 5.5e-18 64.8 0.5 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 PIK60187.1 - 1.2e-07 31.4 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 PIK60188.1 - 2.6e-18 65.9 0.0 4.9e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 PIK60188.1 - 3.5e-12 46.2 1.0 8e-12 45.1 0.5 1.9 2 0 0 2 2 2 1 Acyltransferase C-terminus eIF-5_eIF-2B PF01873.17 PIK60189.1 - 1.3e-24 86.3 0.1 1.4e-23 83.0 0.2 2.5 1 1 1 2 2 2 1 Domain found in IF2B/IF5 HisKA_3 PF07730.13 PIK60189.1 - 0.11 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase NES_C_h PF18208.1 PIK60189.1 - 0.21 11.9 3.5 0.36 11.1 0.2 2.3 2 0 0 2 2 2 0 Nicking enzyme C-terminal middle helical domain TPR_12 PF13424.6 PIK60190.1 - 4.2e-45 151.9 9.6 1.9e-17 63.3 0.5 3.7 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 PIK60190.1 - 1.4e-42 142.4 7.9 4.7e-10 39.0 0.0 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 PIK60190.1 - 3.6e-25 86.1 9.3 3.4e-06 26.7 0.1 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 PIK60190.1 - 1.8e-20 71.8 22.7 6.4e-05 22.6 0.3 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 PIK60190.1 - 6.6e-14 50.8 20.7 0.0028 17.6 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 PIK60190.1 - 1.9e-13 49.4 18.0 0.0022 18.1 0.3 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 PIK60190.1 - 5.5e-12 45.4 2.4 0.92 10.5 0.0 6.2 3 1 3 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK60190.1 - 3.8e-10 40.1 8.3 0.00043 20.7 0.2 4.2 4 1 0 5 5 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK60190.1 - 6.3e-10 39.1 4.6 0.0001 22.4 0.1 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 PIK60190.1 - 2.9e-09 37.4 2.3 0.14 12.8 0.1 4.7 2 2 0 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK60190.1 - 2.7e-07 30.3 0.4 2.7e-07 30.3 0.4 2.9 2 1 0 2 2 2 1 MalT-like TPR region TPR_17 PF13431.6 PIK60190.1 - 2.5e-06 27.4 5.8 0.025 14.9 0.6 5.1 4 1 0 4 4 4 1 Tetratricopeptide repeat Csm1_N PF18504.1 PIK60190.1 - 0.0018 18.6 2.8 0.0086 16.4 2.8 2.2 1 0 0 1 1 1 1 Csm1 N-terminal domain JIP_LZII PF16471.5 PIK60190.1 - 0.0024 18.0 2.0 0.0024 18.0 2.0 2.6 2 0 0 2 2 2 1 JNK-interacting protein leucine zipper II NUDE_C PF04880.13 PIK60190.1 - 0.003 18.1 1.2 0.0059 17.1 1.2 1.5 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region TPR_11 PF13414.6 PIK60190.1 - 0.0034 17.0 14.0 0.056 13.1 0.2 5.0 4 2 1 5 5 5 2 TPR repeat DUF2225 PF09986.9 PIK60190.1 - 0.0058 16.4 0.8 0.26 11.0 0.5 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_4 PF07721.14 PIK60190.1 - 0.012 16.2 0.0 18 6.3 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 PIK60190.1 - 0.014 15.6 4.8 0.88 10.0 0.0 4.6 6 0 0 6 6 4 0 PPR repeat HycH PF07450.11 PIK60190.1 - 0.047 14.1 1.4 0.095 13.1 0.1 2.1 3 0 0 3 3 2 0 Formate hydrogenlyase maturation protein HycH L27 PF02828.16 PIK60190.1 - 0.11 12.2 0.0 0.37 10.6 0.0 1.9 1 0 0 1 1 1 0 L27 domain PPR_2 PF13041.6 PIK60190.1 - 0.2 11.9 0.5 14 5.9 0.1 3.1 3 0 0 3 3 2 0 PPR repeat family Cob_adeno_trans PF01923.18 PIK60190.1 - 0.2 11.8 3.1 1.3 9.2 2.5 2.2 1 1 0 1 1 1 0 Cobalamin adenosyltransferase MIT PF04212.18 PIK60190.1 - 0.71 10.0 15.7 25 5.0 0.6 5.7 3 1 3 6 6 5 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 PIK60190.1 - 0.83 9.7 14.4 1.3 9.1 0.5 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK60190.1 - 1 10.2 8.0 1.4 9.7 0.2 4.4 4 1 0 4 4 3 0 Tetratricopeptide repeat BST2 PF16716.5 PIK60190.1 - 1.4 9.6 8.7 6.5 7.4 5.9 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 ADIP PF11559.8 PIK60190.1 - 1.5 8.9 15.9 0.94 9.5 6.2 3.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.8 PIK60190.1 - 2.6 8.3 17.9 0.07 13.3 4.7 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding PY_rept_46 PF09689.10 PIK60190.1 - 3.3 8.3 5.9 38 4.9 0.2 2.7 2 0 0 2 2 2 0 Plasmodium yoelii repeat (PY_rept_46) TMF_DNA_bd PF12329.8 PIK60190.1 - 5.6 7.0 16.6 0.098 12.7 4.2 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SOGA PF11365.8 PIK60190.1 - 6.9 7.9 12.7 0.84 10.8 4.3 3.4 2 1 1 3 3 2 0 Protein SOGA YfdX PF10938.8 PIK60190.1 - 9.9 6.1 9.6 19 5.1 0.2 3.8 5 0 0 5 5 4 0 YfdX protein RHD_DNA_bind PF00554.22 PIK60191.1 - 1.8e-47 161.4 1.2 1.8e-47 161.4 0.0 1.6 2 0 0 2 2 2 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 PIK60191.1 - 9.3e-34 115.5 0.2 1.8e-33 114.6 0.2 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain FERM_M PF00373.18 PIK60192.1 - 1e-35 122.7 0.0 2.3e-35 121.5 0.0 1.6 1 1 0 1 1 1 1 FERM central domain PH PF00169.29 PIK60192.1 - 2.2e-08 34.6 0.0 6.7e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 PH domain ZU5 PF00791.20 PIK60193.1 - 2.5e-13 50.2 0.0 6e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain HSP70 PF00012.20 PIK60195.1 - 9e-177 588.9 20.6 2.6e-131 438.8 1.2 3.0 1 1 2 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 PIK60195.1 - 1.1e-13 50.7 0.2 1.1e-09 37.6 0.0 3.2 3 0 0 3 3 3 3 MreB/Mbl protein FGGY_C PF02782.16 PIK60195.1 - 0.00023 21.0 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 PIK60195.1 - 0.011 15.0 0.1 0.05 12.8 0.0 2.1 2 0 0 2 2 2 0 StbA protein Hydantoinase_A PF01968.18 PIK60195.1 - 0.013 14.8 0.4 0.071 12.4 0.0 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase FtsA PF14450.6 PIK60195.1 - 0.23 11.9 11.0 4.7 7.7 0.5 4.0 2 2 1 3 3 3 0 Cell division protein FtsA Pkinase PF00069.25 PIK60196.1 - 1.1e-14 54.5 0.0 1.2e-14 54.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 PIK60196.1 - 3.9e-08 32.5 0.0 4.8e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 PIK60196.1 - 6.8e-08 32.1 0.0 6.8e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK60196.1 - 0.11 11.8 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD-3 PF09765.9 PIK60197.1 - 8.2e-64 215.7 5.6 1.6e-39 136.0 2.6 2.7 1 1 1 2 2 2 2 WD-repeat region FANCL_C PF11793.8 PIK60197.1 - 1.4e-11 44.4 3.6 2.7e-11 43.5 3.6 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain DUF2935 PF11155.8 PIK60197.1 - 0.0067 16.8 0.1 0.023 15.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF2935) DUF5051 PF16473.5 PIK60197.1 - 0.037 14.0 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like zf-HC5HC2H PF13771.6 PIK60197.1 - 0.045 14.0 0.5 0.088 13.1 0.5 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain HAD_2 PF13419.6 PIK60197.1 - 0.05 13.7 0.1 0.1 12.7 0.1 1.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase FAA_hydro_N_2 PF18288.1 PIK60197.1 - 0.19 12.1 0.2 5.6 7.5 0.0 2.7 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 zf-RING_2 PF13639.6 PIK60197.1 - 0.66 10.4 9.2 0.38 11.1 4.1 2.3 2 0 0 2 2 2 0 Ring finger domain HAT PF02184.16 PIK60198.1 - 1.8e-18 66.2 19.0 5.7e-09 35.8 0.2 5.2 5 0 0 5 5 5 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 PIK60198.1 - 4.7e-07 30.2 0.0 0.002 18.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK60198.1 - 1.4e-06 28.6 8.4 0.052 14.4 0.1 3.9 2 1 3 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK60198.1 - 0.00038 21.0 0.6 0.53 11.0 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 PIK60198.1 - 0.00055 19.2 6.2 0.042 13.1 3.4 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK60198.1 - 0.00065 19.6 2.8 9.1 6.7 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Suf PF05843.14 PIK60198.1 - 0.0012 18.9 4.9 0.0012 18.9 4.9 1.7 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) U3_assoc_6 PF08640.11 PIK60198.1 - 0.0024 17.9 9.5 0.14 12.2 0.4 3.3 2 1 1 3 3 3 1 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.6 PIK60198.1 - 0.0037 17.8 4.2 4 8.3 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK60198.1 - 0.0057 16.8 2.1 0.33 11.1 0.0 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK60198.1 - 0.12 12.0 0.0 0.42 10.3 0.0 1.9 1 1 0 1 1 1 0 TPR repeat Mad3_BUB1_I PF08311.12 PIK60198.1 - 0.12 12.3 7.9 2.4 8.1 3.9 3.2 2 1 0 2 2 2 0 Mad3/BUB1 homology region 1 TAF8_C PF10406.9 PIK60198.1 - 0.15 12.6 1.1 0.43 11.2 0.3 2.2 2 0 0 2 2 1 0 Transcription factor TFIID complex subunit 8 C-term DUF719 PF05334.13 PIK60198.1 - 0.39 10.9 2.0 0.43 10.8 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF719) TPR_7 PF13176.6 PIK60198.1 - 0.49 10.5 2.6 2.5 8.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK60199.1 - 4.8e-09 36.0 0.4 0.00014 22.0 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat Suf PF05843.14 PIK60199.1 - 7.6e-09 36.0 12.7 0.023 14.7 0.1 4.9 2 2 2 4 4 4 3 Suppressor of forked protein (Suf) HAT PF02184.16 PIK60199.1 - 3.7e-08 33.2 28.5 0.018 15.0 0.2 8.7 8 1 0 8 8 8 3 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 PIK60199.1 - 6.7e-06 26.5 9.9 1.1 10.3 0.1 6.2 6 3 2 8 8 8 2 Tetratricopeptide repeat NRDE-2 PF08424.10 PIK60199.1 - 0.0001 21.6 8.1 0.1 11.7 2.8 3.9 2 2 1 3 3 3 2 NRDE-2, necessary for RNA interference Mad3_BUB1_I PF08311.12 PIK60199.1 - 0.0034 17.4 11.8 0.021 14.8 1.1 4.4 3 1 1 4 4 4 1 Mad3/BUB1 homology region 1 TPR_19 PF14559.6 PIK60199.1 - 0.0054 17.2 0.1 86 3.8 0.0 5.0 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK60199.1 - 0.042 14.5 0.2 70 4.2 0.0 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK60199.1 - 3.3 8.1 5.8 28 5.1 0.0 3.7 6 0 0 6 6 6 0 Tetratricopeptide repeat SPATA3 PF15662.5 PIK60200.1 - 9.3 6.8 11.6 12 6.4 10.2 1.7 1 1 1 2 2 2 0 Spermatogenesis-associated protein 3 family zf-C4 PF00105.18 PIK60201.1 - 2.8e-26 91.8 14.6 5.4e-26 90.8 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ClpS PF02617.17 PIK60202.1 - 5.2e-23 80.6 0.4 2.2e-22 78.6 0.2 2.2 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS zf-UBR PF02207.20 PIK60202.1 - 4.3e-14 52.4 10.7 2.1e-13 50.2 10.7 2.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Ank_2 PF12796.7 PIK60205.1 - 5.2e-33 113.5 2.5 3.5e-12 46.7 0.1 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK60205.1 - 4.1e-25 87.8 10.0 7.2e-10 39.2 0.1 4.7 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK60205.1 - 9.3e-23 80.0 3.3 1e-07 32.0 0.1 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 PIK60205.1 - 3.3e-21 74.7 6.5 4.1e-05 23.8 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 PIK60205.1 - 6e-21 72.3 4.7 0.0017 18.7 0.0 6.4 7 0 0 7 7 7 4 Ankyrin repeat SOCS_box PF07525.16 PIK60205.1 - 5.4e-09 36.3 0.6 5.4e-09 36.3 0.6 2.3 2 1 0 2 2 2 1 SOCS box DUF1843 PF08898.10 PIK60205.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) EMP24_GP25L PF01105.24 PIK60206.1 - 2.3e-41 141.7 0.7 2.6e-41 141.6 0.7 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SRCR PF00530.18 PIK60207.1 - 1.2e-11 45.0 1.4 3e-11 43.7 1.4 1.7 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain EGF PF00008.27 PIK60207.1 - 5e-05 23.5 8.6 9.9e-05 22.6 8.6 1.5 1 0 0 1 1 1 1 EGF-like domain SRCR_2 PF15494.6 PIK60207.1 - 0.00017 22.1 0.3 0.0013 19.2 0.0 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain EGF_2 PF07974.13 PIK60207.1 - 0.00092 19.5 10.8 0.002 18.4 10.8 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_3 PF12947.7 PIK60207.1 - 0.024 14.8 7.4 0.052 13.7 7.4 1.5 1 0 0 1 1 1 0 EGF domain ODV-E18 PF10717.9 PIK60207.1 - 0.042 13.7 0.2 0.071 13.0 0.2 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 WTF PF03303.13 PIK60207.1 - 0.07 12.8 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 WTF protein EGF_MSP1_1 PF12946.7 PIK60207.1 - 0.23 11.5 6.9 0.47 10.6 6.9 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 DUF4408 PF14364.6 PIK60207.1 - 1.8 8.3 8.2 4.9 7.0 8.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4408) EGF_Tenascin PF18720.1 PIK60207.1 - 2 8.5 11.5 0.72 10.0 7.6 2.3 2 1 0 2 2 2 0 Tenascin EGF domain DUF3844 PF12955.7 PIK60207.1 - 4.4 7.5 7.3 16 5.7 7.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3844) Complex1_LYR PF05347.15 PIK60208.1 - 4.3e-07 29.9 0.5 5.9e-07 29.4 0.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 PIK60208.1 - 0.0062 17.3 0.2 0.0072 17.1 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Metal_resist PF13801.6 PIK60208.1 - 0.059 13.6 0.0 0.078 13.2 0.0 1.1 1 0 0 1 1 1 0 Heavy-metal resistance SSL_OB PF09199.10 PIK60208.1 - 0.086 13.2 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 Staphylococcal superantigen-like OB-fold domain Ldh_1_N PF00056.23 PIK60210.1 - 0.0012 18.9 0.0 0.0017 18.5 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain CENP-B_N PF04218.13 PIK60210.1 - 0.2 11.3 0.1 0.31 10.7 0.1 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Peptidase_M1_N PF17900.1 PIK60212.1 - 2.4e-31 109.4 0.1 2.9e-31 109.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 PIK60213.1 - 2.3e-48 165.4 0.1 2.2e-33 116.1 0.0 2.1 1 1 1 2 2 2 2 ERAP1-like C-terminal domain COesterase PF00135.28 PIK60214.1 - 1.1e-105 354.4 0.0 2.6e-58 198.1 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family AChE_tetra PF08674.10 PIK60214.1 - 0.00013 21.6 5.8 0.00027 20.6 5.8 1.6 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.13 PIK60214.1 - 0.001 19.0 0.1 0.34 10.7 0.2 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 PIK60214.1 - 0.03 13.2 0.1 0.21 10.4 0.1 2.0 2 0 0 2 2 2 0 Steryl acetyl hydrolase Collagen PF01391.18 PIK60215.1 - 0.045 13.5 3.2 1.1 9.0 3.2 2.8 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) DUF4538 PF15061.6 PIK60215.1 - 1.6 8.5 3.8 0.64 9.8 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Glyco_hydro81C PF17652.1 PIK60216.1 - 1.5e-24 86.9 5.3 2.2e-22 79.8 1.9 2.1 1 1 0 2 2 2 2 Glycosyl hydrolase family 81 C-terminal domain UBX PF00789.20 PIK60217.1 - 1.2e-06 28.6 0.0 2.1e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 UBX domain DUF2514 PF10721.9 PIK60217.1 - 0.013 15.6 11.8 0.02 14.9 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) TROVE PF05731.11 PIK60219.1 - 8.5e-103 344.8 2.3 2.8e-101 339.8 2.3 2.5 1 1 0 1 1 1 1 TROVE domain RXT2_N PF08595.11 PIK60219.1 - 0.0047 17.0 5.8 0.0047 17.0 5.8 1.8 2 0 0 2 2 2 1 RXT2-like, N-terminal Myc_N PF01056.18 PIK60219.1 - 0.0069 16.3 0.8 0.012 15.5 0.8 1.4 1 0 0 1 1 1 1 Myc amino-terminal region NOA36 PF06524.12 PIK60219.1 - 0.29 10.4 8.6 0.56 9.5 8.6 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 PIK60219.1 - 0.51 8.4 15.8 0.98 7.4 15.8 1.4 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_Rpc4 PF05132.14 PIK60219.1 - 2.8 8.4 6.2 6.1 7.3 6.2 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 FoP_duplication PF13865.6 PIK60219.1 - 4.1 8.0 18.5 0.068 13.7 9.6 2.2 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Sporozoite_P67 PF05642.11 PIK60219.1 - 4.1 5.4 6.7 22 3.0 0.0 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF3464 PF11947.8 PIK60219.1 - 4.3 7.1 5.6 10 5.8 5.6 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CENP-N PF05238.13 PIK60219.1 - 5.8 6.1 8.2 0.87 8.8 4.3 1.5 2 0 0 2 2 2 0 Kinetochore protein CHL4 like DUF4062 PF13271.6 PIK60220.1 - 1.1e-16 60.9 0.0 4.4e-16 59.0 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4062) WD40 PF00400.32 PIK60221.1 - 1.1e-56 187.5 48.2 4.7e-07 30.4 0.0 13.6 11 1 2 13 13 13 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60221.1 - 1.1e-23 83.4 1.9 0.00022 21.5 0.1 7.5 2 2 5 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK60221.1 - 2.7e-06 27.0 0.0 0.00054 19.4 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain NACHT PF05729.12 PIK60221.1 - 2e-05 24.6 0.1 8.4e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 PIK60221.1 - 0.0011 19.4 0.0 0.022 15.1 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 PIK60221.1 - 0.0014 18.5 0.0 0.0037 17.2 0.0 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea APAF1_C PF17908.1 PIK60221.1 - 0.0022 18.0 0.0 0.008 16.2 0.0 1.9 1 1 0 1 1 1 1 APAF-1 helical domain Ge1_WD40 PF16529.5 PIK60221.1 - 0.0059 15.6 3.4 3.7 6.4 0.2 4.3 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Zeta_toxin PF06414.12 PIK60221.1 - 0.013 14.7 0.0 0.032 13.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 PIK60221.1 - 0.016 15.5 0.1 0.16 12.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain KAP_NTPase PF07693.14 PIK60221.1 - 0.051 12.8 0.0 0.68 9.1 0.0 2.1 1 1 0 2 2 2 0 KAP family P-loop domain AAA_29 PF13555.6 PIK60221.1 - 0.093 12.5 0.0 0.39 10.5 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 PIK60221.1 - 0.17 12.3 2.7 0.21 12.1 0.0 2.3 2 1 1 3 3 3 0 AAA domain WD40 PF00400.32 PIK60222.1 - 5.2e-17 61.9 5.5 2.3e-05 25.1 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat CPSF_A PF03178.15 PIK60222.1 - 0.046 13.0 0.1 0.15 11.4 0.1 1.9 1 1 1 2 2 2 0 CPSF A subunit region PE-PPE PF08237.11 PIK60222.1 - 0.16 11.5 0.1 15 5.1 0.0 2.3 2 0 0 2 2 2 0 PE-PPE domain PQQ_3 PF13570.6 PIK60222.1 - 1.3 9.6 6.0 39 4.9 0.0 4.6 6 0 0 6 6 6 0 PQQ-like domain tRNA-synt_1g PF09334.11 PIK60223.1 - 3e-147 490.4 0.0 4.7e-147 489.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) GST_N_5 PF18485.1 PIK60223.1 - 2.2e-20 72.8 0.0 5.1e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK60223.1 - 2.5e-07 30.8 0.5 1.2e-06 28.6 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1 PF00133.22 PIK60223.1 - 1.4e-06 26.9 0.3 0.0012 17.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) GST_C_2 PF13410.6 PIK60223.1 - 3.5e-06 26.9 0.2 1.1e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK60223.1 - 8.6e-06 25.9 0.2 3.1e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Anticodon_1 PF08264.13 PIK60223.1 - 0.00049 20.1 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_C_6 PF17171.4 PIK60223.1 - 0.0028 17.4 0.3 0.0092 15.8 0.3 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK60223.1 - 0.0067 16.8 0.1 0.015 15.6 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain tRNA-synt_1e PF01406.19 PIK60223.1 - 0.062 12.6 0.1 0.56 9.5 0.0 2.3 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain zinc-ribbons_6 PF07191.12 PIK60223.1 - 1.2 9.2 7.6 5.6 7.0 7.6 2.1 1 1 0 1 1 1 0 zinc-ribbons zf-CHY PF05495.12 PIK60223.1 - 1.9 9.0 6.0 8.5 6.9 6.0 2.1 1 1 0 1 1 1 0 CHY zinc finger C1_1 PF00130.22 PIK60223.1 - 3.7 7.5 5.2 4.3 7.3 0.4 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Laminin_EGF PF00053.24 PIK60223.1 - 9.1 6.5 8.9 21 5.3 8.9 1.7 1 0 0 1 1 1 0 Laminin EGF domain PHD PF00628.29 PIK60227.1 - 4.4e-10 39.3 5.4 8.2e-10 38.4 5.4 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK60227.1 - 4.2e-07 29.4 10.3 1.6e-06 27.5 0.6 3.0 3 0 0 3 3 3 2 PHD-finger Prok-RING_1 PF14446.6 PIK60227.1 - 0.00021 21.1 1.9 0.00021 21.1 1.9 1.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 PIK60227.1 - 0.0038 16.9 1.9 0.0094 15.6 1.9 1.7 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain Zf_RING PF16744.5 PIK60227.1 - 0.0038 17.3 4.2 0.0066 16.5 4.2 1.3 1 0 0 1 1 1 1 KIAA1045 RING finger C1_1 PF00130.22 PIK60227.1 - 0.0046 16.8 3.5 0.013 15.4 0.8 2.2 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 PIK60227.1 - 0.063 13.4 7.9 0.35 11.0 7.9 2.3 1 1 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.6 PIK60227.1 - 0.067 13.5 4.6 0.11 12.8 4.6 1.4 1 0 0 1 1 1 0 Ring finger domain C1_2 PF03107.16 PIK60227.1 - 0.3 11.4 4.9 1.3 9.4 1.3 2.4 2 0 0 2 2 2 0 C1 domain DNA_RNApol_7kD PF03604.13 PIK60227.1 - 0.32 10.7 2.9 0.87 9.3 2.9 1.7 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Nop14 PF04147.12 PIK60227.1 - 0.35 9.0 13.0 0.41 8.8 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family zf-C3HC4 PF00097.25 PIK60227.1 - 0.82 9.6 3.8 1.8 8.5 3.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RRN3 PF05327.11 PIK60227.1 - 2.5 6.5 7.3 3.2 6.2 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Astro_capsid_p PF12226.8 PIK60227.1 - 3 6.9 7.6 4.6 6.3 7.6 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RNA_pol_3_Rpc31 PF11705.8 PIK60227.1 - 4.1 7.6 15.0 7.8 6.7 15.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 PIK60227.1 - 8 4.6 7.7 8.7 4.5 7.7 1.2 1 0 0 1 1 1 0 CDC45-like protein zf-HC5HC2H_2 PF13832.6 PIK60228.1 - 8.9e-12 45.1 0.0 1.2e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD PF00628.29 PIK60229.1 - 4.7e-09 36.0 4.9 7.5e-09 35.4 4.9 1.4 1 0 0 1 1 1 1 PHD-finger Zf_RING PF16744.5 PIK60229.1 - 0.0012 18.9 0.5 0.0021 18.1 0.5 1.4 1 0 0 1 1 1 1 KIAA1045 RING finger C1_2 PF03107.16 PIK60229.1 - 0.0021 18.4 0.8 0.0034 17.7 0.8 1.3 1 0 0 1 1 1 1 C1 domain zf-HC5HC2H PF13771.6 PIK60229.1 - 0.0022 18.2 0.4 0.005 17.1 0.4 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain Sec34 PF04136.15 PIK60229.1 - 0.0037 17.2 1.9 0.0065 16.4 1.9 1.4 1 0 0 1 1 1 1 Sec34-like family DHC_N2 PF08393.13 PIK60229.1 - 0.0049 16.0 0.3 0.0064 15.6 0.3 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 C1_1 PF00130.22 PIK60229.1 - 0.0073 16.2 2.9 0.012 15.4 2.9 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Dor1 PF04124.12 PIK60229.1 - 0.0087 14.8 1.1 0.012 14.4 1.1 1.2 1 0 0 1 1 1 1 Dor1-like family zf-HC5HC2H_2 PF13832.6 PIK60229.1 - 0.0089 16.2 0.4 0.018 15.2 0.4 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain Rootletin PF15035.6 PIK60229.1 - 0.014 15.5 3.0 0.02 14.9 3.0 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion AAA_15 PF13175.6 PIK60229.1 - 0.044 13.5 3.1 0.057 13.1 3.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain FANCL_C PF11793.8 PIK60229.1 - 0.083 13.1 3.4 0.14 12.3 3.4 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Wtap PF17098.5 PIK60229.1 - 0.1 12.5 3.0 0.11 12.4 0.5 1.9 1 1 1 2 2 2 0 WTAP/Mum2p family zf-RING_2 PF13639.6 PIK60229.1 - 0.15 12.4 5.7 0.23 11.8 5.7 1.3 1 0 0 1 1 1 0 Ring finger domain DUF4298 PF14131.6 PIK60229.1 - 0.15 12.0 3.6 0.25 11.3 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) Prok-RING_1 PF14446.6 PIK60229.1 - 0.2 11.6 5.4 0.36 10.8 5.4 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 APG6_N PF17675.1 PIK60229.1 - 0.36 11.4 7.7 0.75 10.3 7.8 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region Plasmid_RAQPRD PF09686.10 PIK60229.1 - 0.46 10.7 2.8 4.2 7.7 0.1 2.2 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DivIC PF04977.15 PIK60229.1 - 3 7.7 6.6 0.86 9.4 1.7 2.1 1 1 1 2 2 2 0 Septum formation initiator PHD PF00628.29 PIK60230.1 - 3.1e-12 46.2 8.4 4.5e-12 45.7 8.4 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 PIK60230.1 - 0.0017 18.6 3.3 0.0023 18.1 3.3 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 PIK60230.1 - 0.012 15.7 1.3 0.017 15.2 1.3 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain Zf_RING PF16744.5 PIK60230.1 - 0.016 15.3 11.5 0.23 11.6 11.5 2.2 1 1 0 1 1 1 0 KIAA1045 RING finger zf-RING_2 PF13639.6 PIK60230.1 - 0.033 14.5 8.4 0.051 13.9 8.4 1.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_9 PF13901.6 PIK60230.1 - 0.045 13.7 5.9 0.073 13.0 5.7 1.6 1 1 1 2 2 2 0 Putative zinc-RING and/or ribbon C1_1 PF00130.22 PIK60230.1 - 0.16 11.9 6.8 0.065 13.1 3.0 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_17 PF17120.5 PIK60230.1 - 0.18 11.5 6.7 0.56 9.9 6.7 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 PIK60230.1 - 0.55 10.2 9.0 0.36 10.8 4.8 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 PIK60230.1 - 0.61 9.7 9.6 0.19 11.3 5.5 2.1 2 0 0 2 2 2 0 PHD-finger C1_2 PF03107.16 PIK60230.1 - 0.99 9.8 9.6 0.25 11.7 4.9 2.0 2 0 0 2 2 2 0 C1 domain zf-MIZ PF02891.20 PIK60230.1 - 2.1 8.1 7.6 0.58 10.0 4.0 2.0 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger Glyco_transf_29 PF00777.18 PIK60232.1 - 3.2e-24 85.8 0.1 6.8e-22 78.1 0.0 2.3 1 1 1 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) TPH PF13868.6 PIK60233.1 - 3.4e-44 150.8 95.8 4.5e-44 150.4 95.8 1.1 1 0 0 1 1 1 1 Trichohyalin-plectin-homology domain TPH PF13868.6 PIK60234.1 - 1.5e-09 36.8 22.7 1.5e-09 36.8 22.7 2.1 1 1 0 1 1 1 1 Trichohyalin-plectin-homology domain Fmp27_SW PF10305.9 PIK60234.1 - 9.8 7.0 8.1 0.66 10.7 1.7 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Snapin_Pallidin PF14712.6 PIK60235.1 - 3.9e-18 65.7 5.9 3.9e-18 65.7 5.9 1.9 1 1 1 2 2 2 1 Snapin/Pallidin FAP206 PF12018.8 PIK60235.1 - 0.023 14.2 5.6 0.035 13.6 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function PBP_sp32 PF07222.12 PIK60235.1 - 1.3 8.5 11.1 0.017 14.6 2.1 1.9 1 1 1 2 2 2 0 Proacrosin binding protein sp32 DUF3337 PF11816.8 PIK60235.1 - 2.1 8.2 8.3 1.2 9.0 4.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3337) PhaP_Bmeg PF09602.10 PIK60238.1 - 0.002 18.1 7.2 0.014 15.3 1.0 2.6 1 1 2 3 3 3 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Fib_alpha PF08702.10 PIK60238.1 - 0.15 12.2 5.9 0.55 10.4 0.1 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF2254 PF10011.9 PIK60239.1 - 0.8 8.5 4.2 0.79 8.5 2.3 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2254) Peptidase_M9_N PF08453.10 PIK60240.1 - 0.009 15.7 0.8 0.018 14.8 0.8 1.5 1 0 0 1 1 1 1 Peptidase family M9 N-terminal Transposase_21 PF02992.14 PIK60241.1 - 0.065 12.5 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Transposase family tnp2 FAST_2 PF08368.12 PIK60242.1 - 2.8e-17 63.3 0.0 6.7e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 PIK60242.1 - 9.4e-05 22.3 8.5 0.024 14.6 0.2 4.0 3 1 1 4 4 4 2 FAST kinase-like protein, subdomain 1 DUF1539 PF07560.11 PIK60242.1 - 0.048 13.7 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) Kelch_1 PF01344.25 PIK60243.1 - 2.1e-43 145.6 6.1 1.7e-13 49.9 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 PIK60243.1 - 3.2e-33 112.9 0.1 2.9e-08 33.7 0.0 5.0 4 1 1 5 5 5 4 Kelch motif BACK PF07707.15 PIK60243.1 - 2.3e-31 108.0 1.0 5.7e-31 106.7 0.2 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 PIK60243.1 - 8.2e-30 102.6 0.0 2e-08 34.1 0.0 5.8 6 0 0 6 6 6 4 Galactose oxidase, central domain BTB PF00651.31 PIK60243.1 - 5.9e-28 97.3 0.2 1.2e-27 96.3 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 PIK60243.1 - 2.5e-18 65.2 0.1 0.00046 20.0 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 PIK60243.1 - 4.3e-18 65.1 0.1 0.0029 17.9 0.0 4.8 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK60243.1 - 3.4e-12 46.1 0.0 0.043 13.8 0.0 5.1 5 0 0 5 5 5 3 Kelch motif DUF3342 PF11822.8 PIK60243.1 - 0.048 13.9 0.4 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) IL6 PF00489.17 PIK60244.1 - 0.023 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family T2SSE PF00437.20 PIK60245.1 - 0.077 12.0 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.21 PIK60245.1 - 0.089 12.3 6.3 0.03 13.9 2.1 2.5 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 PIK60245.1 - 0.13 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ADAM_spacer1 PF05986.14 PIK60246.1 - 7.9e-20 71.0 0.0 1.3e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 NTR PF01759.21 PIK60246.1 - 3.1e-15 55.9 0.0 3.1e-15 55.9 0.0 1.7 2 0 0 2 2 2 1 UNC-6/NTR/C345C module ADAM_CR_2 PF17771.1 PIK60246.1 - 0.00036 21.0 1.3 0.0013 19.2 1.3 2.0 1 0 0 1 1 1 1 ADAM cysteine-rich domain RasGAP PF00616.19 PIK60246.1 - 0.031 14.0 2.0 0.049 13.3 2.0 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase CCDC106 PF15794.5 PIK60246.1 - 0.032 14.0 8.0 0.055 13.2 8.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RR_TM4-6 PF06459.12 PIK60246.1 - 0.15 11.8 6.7 0.23 11.3 6.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 PIK60246.1 - 0.29 9.9 0.3 0.37 9.5 0.3 1.1 1 0 0 1 1 1 0 Presenilin YqfQ PF14181.6 PIK60246.1 - 0.29 11.3 9.9 0.54 10.4 9.9 1.3 1 0 0 1 1 1 0 YqfQ-like protein RNA_pol_Rpc4 PF05132.14 PIK60246.1 - 0.52 10.7 7.9 0.85 10.0 7.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 PPTA PF01239.22 PIK60247.1 - 3.9e-15 55.0 12.5 0.0011 18.6 0.3 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Ras PF00071.22 PIK60248.1 - 3.1e-39 134.2 0.1 5.6e-39 133.3 0.0 1.4 2 0 0 2 2 2 1 Ras family Roc PF08477.13 PIK60248.1 - 3.8e-10 40.0 0.0 8.9e-10 38.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK60248.1 - 0.0012 18.4 0.0 0.0024 17.4 0.0 1.5 1 1 1 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK60248.1 - 0.0097 15.5 0.0 0.013 15.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 PIK60248.1 - 0.16 11.7 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Filament PF00038.21 PIK60249.1 - 0.0017 18.0 24.1 0.0017 18.0 24.1 13.0 5 3 6 13 13 13 9 Intermediate filament protein ZapB PF06005.12 PIK60249.1 - 0.0021 18.5 10.1 0.0021 18.5 10.1 22.7 9 4 9 18 18 18 3 Cell division protein ZapB Arb2 PF09757.9 PIK60250.1 - 8.5e-05 21.8 0.1 0.00013 21.2 0.1 1.2 1 0 0 1 1 1 1 Arb2 domain Esterase PF00756.20 PIK60250.1 - 0.0053 16.4 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 PIK60250.1 - 0.0054 16.0 0.1 0.011 15.1 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 PIK60250.1 - 0.0056 16.6 0.0 0.05 13.5 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_1 PF00561.20 PIK60250.1 - 0.013 15.2 0.0 0.025 14.2 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold 120_Rick_ant PF12574.8 PIK60250.1 - 0.015 14.5 0.5 0.03 13.5 0.5 1.5 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen Abhydrolase_6 PF12697.7 PIK60250.1 - 0.025 15.2 0.0 0.03 14.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 PIK60250.1 - 0.06 13.1 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein zf-C2H2 PF00096.26 PIK60251.1 - 1.1e-05 25.6 36.4 0.0045 17.4 5.4 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60251.1 - 0.00047 20.8 33.0 0.028 15.2 4.8 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK60251.1 - 0.0029 18.0 2.5 0.0029 18.0 2.5 4.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK60251.1 - 0.024 14.6 5.8 0.024 14.6 5.8 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger YmgD PF16456.5 PIK60251.1 - 0.12 12.5 23.5 1.8 8.6 2.6 6.5 1 1 3 5 5 5 0 YmgD protein zf-C2H2_11 PF16622.5 PIK60251.1 - 0.61 9.9 22.5 1.5 8.7 2.8 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type DUF2853 PF11015.8 PIK60251.1 - 1.3 9.7 12.0 4 8.2 0.0 5.2 2 1 1 5 5 5 0 Protein of unknown function (DUF2853) zf-C2H2_jaz PF12171.8 PIK60251.1 - 3.3 8.1 27.7 0.3 11.4 1.4 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK60251.1 - 9.3 6.8 24.8 6 7.4 3.9 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK60252.1 - 3.3e-14 52.4 27.4 1.3e-05 25.3 0.6 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60252.1 - 1.7e-07 31.5 25.9 0.0028 18.3 0.6 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK60252.1 - 2.3e-07 30.9 21.1 0.00066 20.0 0.2 5.2 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK60252.1 - 2.3e-06 27.7 19.9 0.0029 17.9 0.1 4.0 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK60252.1 - 0.00035 20.8 11.4 0.0037 17.5 0.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 PIK60252.1 - 0.0025 17.8 22.3 0.19 11.7 1.4 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 PIK60252.1 - 0.01 16.2 17.6 0.086 13.3 0.4 4.2 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-CCHC_2 PF13696.6 PIK60252.1 - 1.4 8.8 11.6 5.9 6.8 1.1 3.6 3 0 0 3 3 3 0 Zinc knuckle CpXC PF14353.6 PIK60252.1 - 3.8 7.6 11.6 12 5.9 2.3 3.0 2 2 0 2 2 2 0 CpXC protein Zn-ribbon_8 PF09723.10 PIK60252.1 - 3.8 7.7 12.9 22 5.3 0.6 3.9 3 1 1 4 4 4 0 Zinc ribbon domain zf-3CxxC PF13695.6 PIK60252.1 - 4.8 7.7 9.0 1.2 9.6 0.6 2.6 2 1 0 2 2 2 0 Zinc-binding domain zf-CHY PF05495.12 PIK60252.1 - 4.9 7.7 17.4 6.2 7.4 6.2 2.7 2 1 0 2 2 2 0 CHY zinc finger DUF2256 PF10013.9 PIK60252.1 - 6.5 7.0 10.9 1.5 9.0 0.5 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) ADK_lid PF05191.14 PIK60252.1 - 8.9 6.4 7.5 13 5.9 1.2 3.4 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-H2C2_2 PF13465.6 PIK60253.1 - 2.2e-37 125.8 52.5 4.5e-07 30.0 0.3 7.1 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK60253.1 - 1.3e-19 69.5 61.7 4e-05 23.8 3.1 6.2 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60253.1 - 1.6e-17 62.6 55.4 0.0043 17.8 7.1 6.2 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK60253.1 - 5.2e-12 45.7 27.8 0.0042 17.3 0.1 6.3 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK60253.1 - 3.5e-09 36.7 43.3 0.045 14.1 1.9 6.2 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK60253.1 - 0.00092 19.2 10.4 0.0079 16.2 2.3 6.5 6 1 0 6 6 6 3 C2H2-type zinc finger DUF3850 PF12961.7 PIK60253.1 - 0.0025 17.8 0.0 8.1 6.6 0.0 3.4 3 1 0 3 3 3 1 Domain of unknown function (DUF3850) C1_4 PF07975.12 PIK60253.1 - 0.015 15.5 27.6 0.59 10.4 3.3 4.0 2 1 2 4 4 4 0 TFIIH C1-like domain BolA PF01722.18 PIK60253.1 - 0.021 15.1 8.0 3.3 8.0 0.3 4.1 2 2 2 4 4 4 0 BolA-like protein zf-C2H2_3rep PF18868.1 PIK60253.1 - 0.057 14.1 23.5 0.52 11.0 4.3 4.5 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats Zf_RING PF16744.5 PIK60253.1 - 0.058 13.5 29.3 3.6 7.8 0.4 5.9 1 1 5 6 6 6 0 KIAA1045 RING finger zinc_ribbon_15 PF17032.5 PIK60253.1 - 0.076 13.8 19.1 0.53 11.1 0.9 3.7 3 1 1 4 4 4 0 zinc-ribbon family zf_UBZ PF18439.1 PIK60253.1 - 0.23 11.1 0.1 0.23 11.1 0.1 5.6 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger FYDLN_acid PF09538.10 PIK60253.1 - 1.5 9.5 14.1 40 4.9 3.5 4.9 1 1 4 5 5 5 0 Protein of unknown function (FYDLN_acid) DUF2256 PF10013.9 PIK60253.1 - 1.5 9.0 27.1 1.2 9.3 1.2 6.0 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-AN1 PF01428.16 PIK60253.1 - 1.5 9.0 34.7 2.8 8.2 0.2 6.3 5 1 1 6 6 6 0 AN1-like Zinc finger zinc-ribbons_6 PF07191.12 PIK60253.1 - 2.2 8.3 24.8 5.4 7.1 4.0 4.9 1 1 4 5 5 5 0 zinc-ribbons GAGA PF09237.11 PIK60253.1 - 7.8 6.4 25.9 3.2 7.6 0.9 5.6 1 1 5 6 6 6 0 GAGA factor DUF758 PF05527.11 PIK60254.1 - 5.1e-54 183.0 3.8 5.6e-54 182.9 3.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) PFO_beta_C PF12367.8 PIK60254.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal adh_short PF00106.25 PIK60255.1 - 7.4e-45 152.8 0.1 9.1e-45 152.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK60255.1 - 1.2e-28 100.3 0.0 1.6e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK60255.1 - 4.5e-12 46.2 0.0 6e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 PIK60256.1 - 5.5e-31 107.5 0.2 6.9e-31 107.2 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK60256.1 - 9.6e-21 74.4 0.1 1.2e-20 74.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK60256.1 - 1.8e-07 31.3 0.1 2.4e-07 30.9 0.1 1.1 1 0 0 1 1 1 1 KR domain RRM_1 PF00076.22 PIK60258.1 - 5e-30 103.1 0.3 3.6e-14 52.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK60258.1 - 8.1e-07 29.1 0.1 2.4e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif RRM_1 PF00076.22 PIK60259.1 - 9e-32 108.7 0.1 2.7e-17 62.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK60259.1 - 9.4e-10 38.5 0.0 4.8e-07 29.8 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 PIK60259.1 - 0.00013 22.0 0.0 0.0037 17.3 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.6 PIK60259.1 - 0.0025 17.4 0.0 0.0062 16.1 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Laminin_G_1 PF00054.23 PIK60259.1 - 0.004 17.4 0.7 0.013 15.7 0.0 2.1 3 0 0 3 3 3 1 Laminin G domain HYR PF02494.16 PIK60260.1 - 8.7e-19 67.6 2.1 1.9e-15 56.9 0.1 2.7 3 0 0 3 3 3 2 HYR domain Zona_pellucida PF00100.23 PIK60261.1 - 2.2e-42 145.6 5.5 3.6e-42 144.9 5.5 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain RVT_1 PF00078.27 PIK60262.1 - 6e-26 91.3 0.1 1.2e-25 90.4 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK60262.1 - 1.3e-14 54.4 0.0 2.8e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK60262.1 - 5.2e-12 45.7 0.0 2.5e-11 43.5 0.0 2.3 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK60262.1 - 0.032 14.0 0.0 0.082 12.7 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH PF17917.1 PIK60262.1 - 0.059 13.7 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60263.1 - 2e-27 96.1 0.1 2.3e-27 95.9 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zona_pellucida PF00100.23 PIK60264.1 - 3e-26 92.8 0.8 6.5e-26 91.7 0.8 1.6 1 0 0 1 1 1 1 Zona pellucida-like domain RT_RNaseH_2 PF17919.1 PIK60265.1 - 3.1e-33 113.8 0.1 7e-33 112.7 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60265.1 - 3.4e-27 94.8 0.0 6.1e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK60265.1 - 6.8e-15 54.9 0.3 6.8e-15 54.9 0.3 2.1 3 0 0 3 3 3 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK60265.1 - 3e-12 46.5 0.0 5.7e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBP_BcsF PF11120.8 PIK60265.1 - 0.13 12.4 0.9 0.27 11.4 0.9 1.5 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF zf-H2C2 PF09337.10 PIK60265.1 - 0.22 11.7 2.3 1.6 9.0 0.0 2.7 3 0 0 3 3 3 0 H2C2 zinc finger FAM101 PF15068.6 PIK60266.1 - 0.00082 19.4 0.7 0.00093 19.2 0.7 1.1 1 0 0 1 1 1 1 FAM101 family TMEM132 PF16070.5 PIK60267.1 - 6.1e-90 302.0 0.5 1.2e-89 301.1 0.3 1.5 2 0 0 2 2 2 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 PIK60267.1 - 5e-12 45.4 0.0 1.2e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Orf78 PF06024.12 PIK60267.1 - 0.0021 18.3 0.0 0.0085 16.4 0.0 2.0 2 0 0 2 2 2 1 Orf78 (ac78) SLAC1 PF03595.17 PIK60267.1 - 0.0047 16.2 0.1 0.0071 15.6 0.1 1.2 1 0 0 1 1 1 1 Voltage-dependent anion channel Saf_2TM PF18303.1 PIK60267.1 - 0.02 14.5 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF5383 PF17355.2 PIK60267.1 - 0.099 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5383) Cadherin_C_2 PF16492.5 PIK60267.1 - 0.11 13.3 0.0 0.31 11.8 0.0 1.9 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal MAM PF00629.23 PIK60268.1 - 4.7e-111 367.9 0.6 8.3e-37 126.6 0.0 4.2 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK60268.1 - 1.1e-20 73.5 66.5 6e-07 29.6 9.5 4.5 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A DUF3149 PF11346.8 PIK60268.1 - 0.0054 16.3 0.3 0.013 15.1 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3149) Ldl_recept_a PF00057.18 PIK60269.1 - 5.8e-09 36.0 12.0 7.4e-09 35.7 12.0 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Omega-toxin PF06357.11 PIK60269.1 - 0.0073 16.1 0.9 0.014 15.2 0.9 1.5 1 0 0 1 1 1 1 Omega-atracotoxin MAM PF00629.23 PIK60270.1 - 2.2e-63 213.0 0.7 1.7e-36 125.6 0.1 2.6 3 0 0 3 3 3 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK60270.1 - 4.7e-05 23.5 26.1 0.0036 17.5 4.1 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A MAM PF00629.23 PIK60271.1 - 9.9e-55 184.8 0.0 1.6e-39 135.4 0.0 2.1 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK60271.1 - 1.4e-07 31.6 8.8 1.4e-07 31.6 8.8 2.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A SKG6 PF08693.10 PIK60271.1 - 0.002 17.5 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Pkinase_Tyr PF07714.17 PIK60272.1 - 1.1e-43 149.5 0.0 1.5e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60272.1 - 1.2e-16 60.9 0.0 1.6e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DAP_epimerase PF01678.19 PIK60272.1 - 0.079 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelate epimerase DUF2944 PF11161.8 PIK60272.1 - 0.18 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) Zip PF02535.22 PIK60273.1 - 4.4e-57 193.8 21.3 4.4e-57 193.8 21.3 2.8 2 1 0 2 2 2 1 ZIP Zinc transporter ZIP4_domain PF18292.1 PIK60273.1 - 2.9e-12 46.8 3.2 2.2e-09 37.5 0.0 2.7 3 0 0 3 3 3 2 Zinc transporter ZIP4 domain Smoothelin PF12510.8 PIK60273.1 - 0.097 12.7 2.4 3.4 7.8 0.1 2.5 2 0 0 2 2 2 0 Smoothelin cytoskeleton protein RVT_1 PF00078.27 PIK60274.1 - 9.9e-11 41.6 0.0 1.6e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5516 PF17637.2 PIK60275.1 - 1 9.1 5.5 1.2 8.9 1.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5516) Acyl-CoA_dh_1 PF00441.24 PIK60277.1 - 1.5e-20 74.0 0.5 2e-20 73.5 0.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 PIK60277.1 - 4.1e-20 71.8 0.0 7.7e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK60277.1 - 1.4e-11 45.1 0.0 2.8e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK60277.1 - 1.5e-08 34.9 1.0 2.1e-08 34.5 1.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RPW8 PF05659.11 PIK60278.1 - 0.17 11.5 1.5 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ZYG-11_interact PF05884.12 PIK60278.1 - 0.24 10.8 0.3 0.37 10.1 0.3 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 SKA2 PF16740.5 PIK60279.1 - 2.9e-21 75.3 7.4 2.9e-21 75.3 7.4 1.6 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 2 DUF3161 PF11362.8 PIK60279.1 - 5.7e-17 61.5 0.0 1.7e-16 59.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3161) SKA1 PF07160.12 PIK60279.1 - 3.2e-06 27.2 6.2 4.4e-06 26.7 4.5 2.0 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 1 Tup_N PF08581.10 PIK60279.1 - 0.0011 19.2 6.3 0.004 17.4 1.9 2.6 3 0 0 3 3 2 1 Tup N-terminal ATP-synt_D PF01813.17 PIK60279.1 - 0.0018 18.1 1.4 0.0018 18.1 1.4 1.9 2 1 0 2 2 2 1 ATP synthase subunit D HBM PF16591.5 PIK60279.1 - 0.0021 17.6 3.2 0.056 12.9 1.6 2.2 2 0 0 2 2 2 1 Helical bimodular sensor domain DUF1043 PF06295.12 PIK60279.1 - 0.0034 17.4 5.3 0.21 11.6 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1043) DUF4208 PF13907.6 PIK60279.1 - 0.011 16.1 1.8 0.14 12.6 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) EzrA PF06160.12 PIK60279.1 - 0.031 12.5 4.0 0.72 7.9 3.3 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA IL11 PF07400.11 PIK60279.1 - 0.037 13.7 0.8 0.078 12.6 0.6 1.6 1 1 0 1 1 1 0 Interleukin 11 DUF3921 PF13060.6 PIK60279.1 - 0.061 13.4 0.2 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) OmpH PF03938.14 PIK60279.1 - 0.11 12.8 9.4 0.15 12.4 7.8 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HAP1_N PF04849.13 PIK60279.1 - 0.13 11.4 9.8 0.28 10.4 5.9 2.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Filament PF00038.21 PIK60279.1 - 0.14 11.7 6.2 0.27 10.8 6.2 1.4 1 0 0 1 1 1 0 Intermediate filament protein FlaC_arch PF05377.11 PIK60279.1 - 0.18 12.3 5.7 3.2 8.2 0.9 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HIP1_clath_bdg PF16515.5 PIK60279.1 - 0.21 12.2 9.4 0.12 13.0 6.4 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 PIK60279.1 - 0.24 10.3 8.8 0.31 9.9 7.5 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein TolA_bind_tri PF16331.5 PIK60279.1 - 0.37 10.9 7.1 2.1 8.5 7.1 2.2 1 1 0 1 1 1 0 TolA binding protein trimerisation Occludin_ELL PF07303.13 PIK60279.1 - 0.39 11.5 5.4 0.83 10.4 1.5 2.8 3 0 0 3 3 3 0 Occludin homology domain BLOC1_2 PF10046.9 PIK60279.1 - 0.58 10.5 7.7 8.9 6.7 3.2 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 XhlA PF10779.9 PIK60279.1 - 0.91 9.8 5.5 0.63 10.3 1.3 2.4 2 0 0 2 2 2 0 Haemolysin XhlA DASH_Dad2 PF08654.10 PIK60279.1 - 5.1 7.6 8.3 3.9 8.0 5.7 2.3 2 1 0 2 2 1 0 DASH complex subunit Dad2 Pescadillo_N PF06732.11 PIK60280.1 - 1.3e-59 202.0 8.5 7.7e-41 140.4 2.9 3.5 1 1 2 3 3 3 3 Pescadillo N-terminus BRCT_2 PF16589.5 PIK60280.1 - 3.2e-11 43.5 2.1 6.8e-11 42.4 0.1 2.5 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK60280.1 - 5.1e-08 33.2 0.3 1.7e-07 31.5 0.1 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 PIK60280.1 - 0.019 15.3 0.3 0.11 12.8 0.0 2.5 2 1 0 2 2 2 0 DNA ligase 3 BRCT domain Hid1 PF12722.7 PIK60283.1 - 1.8 6.6 7.0 3.7 5.5 7.0 1.5 1 1 0 1 1 1 0 High-temperature-induced dauer-formation protein DEK_C PF08766.11 PIK60284.1 - 1.8e-08 34.2 0.1 3.6e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 DEK C terminal domain Dicty_REP PF05086.12 PIK60284.1 - 3 5.7 6.6 5.3 4.9 6.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein EF-hand_6 PF13405.6 PIK60287.1 - 4.3e-05 23.1 6.3 8.9e-05 22.1 0.9 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 PIK60287.1 - 8.7e-05 21.8 1.7 8.7e-05 21.8 1.7 3.4 4 0 0 4 4 4 1 EF hand Dpy-30 PF05186.13 PIK60287.1 - 0.00053 19.6 1.2 0.051 13.3 0.0 2.6 2 0 0 2 2 2 2 Dpy-30 motif EF-hand_7 PF13499.6 PIK60287.1 - 0.00083 19.8 9.6 0.0054 17.2 1.3 4.4 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 PIK60287.1 - 0.089 12.3 3.6 0.11 12.1 1.8 2.2 2 0 0 2 2 2 0 EF hand EF-hand_10 PF14788.6 PIK60287.1 - 0.57 10.1 3.1 1.5 8.8 0.1 2.8 3 0 0 3 3 3 0 EF hand ATC_hydrolase PF14196.6 PIK60289.1 - 0.099 13.4 0.1 0.12 13.1 0.1 1.1 1 0 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase DUF624 PF04854.14 PIK60289.1 - 1.1 9.4 8.7 0.21 11.7 2.7 2.5 2 1 1 3 3 3 0 Protein of unknown function, DUF624 Rhodanese PF00581.20 PIK60290.1 - 2.3e-08 34.5 0.0 4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_A22B PF04258.13 PIK60291.1 - 8.6e-84 281.4 16.3 1e-83 281.2 16.3 1.1 1 0 0 1 1 1 1 Signal peptide peptidase MNHE PF01899.16 PIK60291.1 - 1.3 8.8 19.6 0.91 9.3 6.4 3.1 3 0 0 3 3 3 0 Na+/H+ ion antiporter subunit AbiEi_3_N PF17194.4 PIK60293.1 - 0.038 14.0 1.5 0.14 12.2 1.5 2.0 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain TMPIT PF07851.13 PIK60294.1 - 0.22 10.7 0.7 0.29 10.3 0.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein TBCC PF07986.12 PIK60295.1 - 6.2e-32 109.8 0.1 1.7e-31 108.5 0.1 1.8 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 PIK60295.1 - 0.0041 16.7 2.6 0.0075 15.9 2.6 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal rve_3 PF13683.6 PIK60296.1 - 0.018 14.8 0.9 0.23 11.3 0.1 2.3 2 0 0 2 2 2 0 Integrase core domain ERM PF00769.19 PIK60297.1 - 8.3e-08 32.4 105.4 0.0035 17.2 39.1 3.1 1 1 3 4 4 4 4 Ezrin/radixin/moesin family GAS PF13851.6 PIK60297.1 - 1.3e-07 31.2 93.8 0.006 16.0 22.7 4.4 1 1 4 5 5 5 5 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 PIK60297.1 - 5.2e-07 30.3 109.0 0.012 16.1 26.1 4.5 1 1 3 4 4 4 4 Apg6 coiled-coil region KASH_CCD PF14662.6 PIK60297.1 - 1.7e-05 24.8 93.1 0.0023 17.8 34.6 4.4 1 1 3 4 4 4 3 Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg PF16515.5 PIK60297.1 - 0.00015 22.3 95.3 0.0041 17.7 17.6 5.1 1 1 2 5 5 5 4 Clathrin-binding domain of Huntingtin-interacting protein 1 Lebercilin PF15619.6 PIK60297.1 - 0.00029 20.6 89.4 0.18 11.4 44.2 4.7 1 1 1 3 3 3 3 Ciliary protein causing Leber congenital amaurosis disease DUF4472 PF14739.6 PIK60297.1 - 0.0034 18.1 81.1 3 8.6 18.4 5.4 1 1 5 6 6 6 4 Domain of unknown function (DUF4472) HBM PF16591.5 PIK60297.1 - 0.006 16.0 57.8 0.43 10.0 33.9 4.4 1 1 2 3 3 3 2 Helical bimodular sensor domain Cep57_MT_bd PF06657.13 PIK60297.1 - 0.011 16.1 61.6 0.52 10.8 9.3 6.9 1 1 5 6 6 6 0 Centrosome microtubule-binding domain of Cep57 Fez1 PF06818.15 PIK60297.1 - 0.021 15.3 84.9 0.49 10.8 32.2 3.3 1 1 2 3 3 3 0 Fez1 TACC_C PF05010.14 PIK60297.1 - 0.042 13.6 78.2 0.24 11.2 43.0 3.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Spc7 PF08317.11 PIK60297.1 - 1.2 7.9 85.0 0.92 8.3 30.0 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein TPD52 PF04201.15 PIK60297.1 - 1.2 8.7 79.0 2.1 7.9 5.4 6.8 1 1 6 7 7 7 0 Tumour protein D52 family DUF3128 PF11326.8 PIK60297.1 - 1.5 9.2 45.9 0.76 10.2 1.6 6.1 1 1 5 6 6 6 0 Protein of unknown function (DUF3128) CcdB PF01845.17 PIK60297.1 - 1.7 8.9 7.4 5.4 7.3 0.1 4.3 1 1 4 6 6 6 0 CcdB protein DUF4600 PF15372.6 PIK60297.1 - 1.8 9.0 70.1 11 6.5 13.6 6.1 1 1 5 6 6 6 0 Domain of unknown function (DUF4600) DUF1664 PF07889.12 PIK60297.1 - 3.4 7.7 50.6 0.21 11.6 10.4 4.7 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) PilA4 PF18682.1 PIK60297.1 - 4.1 7.8 22.5 4.5 7.7 0.5 6.5 2 1 4 7 7 7 0 Pilin A4 ATG16 PF08614.11 PIK60297.1 - 7.3 6.8 100.3 2.4 8.3 24.6 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ZU5 PF00791.20 PIK60298.1 - 0.063 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 ZU5 domain CSN5_C PF18323.1 PIK60298.1 - 0.13 13.2 0.7 0.22 12.5 0.7 1.4 1 0 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain TFB6 PF17110.5 PIK60298.1 - 0.3 10.8 4.2 0.59 9.9 4.2 1.5 1 1 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ZU5 PF00791.20 PIK60299.1 - 0.11 12.8 0.1 0.63 10.4 0.0 2.1 2 0 0 2 2 2 0 ZU5 domain Ribosomal_L16 PF00252.18 PIK60300.1 - 3e-05 24.0 0.6 0.00094 19.2 0.3 2.7 2 1 0 2 2 2 1 Ribosomal protein L16p/L10e Thioredoxin_8 PF13905.6 PIK60300.1 - 0.015 15.6 0.0 0.026 14.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like WD40_like PF17005.5 PIK60301.1 - 0.0047 16.3 0.0 0.0062 15.9 0.0 1.1 1 0 0 1 1 1 1 WD40-like domain PQQ_3 PF13570.6 PIK60301.1 - 0.015 15.8 0.0 0.17 12.4 0.0 2.4 2 1 1 3 3 3 0 PQQ-like domain PQQ_2 PF13360.6 PIK60301.1 - 0.16 11.6 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 PQQ-like domain ZU5 PF00791.20 PIK60302.1 - 6.7e-20 71.3 2.5 2e-09 37.7 0.1 3.0 3 0 0 3 3 3 2 ZU5 domain Phage_tail_T PF06223.12 PIK60302.1 - 0.05 14.1 0.8 8 7.1 0.0 2.9 3 0 0 3 3 3 0 Minor tail protein T BLACT_WH PF17778.1 PIK60302.1 - 0.059 13.4 0.0 12 6.0 0.0 2.5 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain Scytalone_dh PF02982.14 PIK60302.1 - 0.12 12.2 0.5 0.66 9.8 0.1 2.3 3 0 0 3 3 3 0 Scytalone dehydratase ZU5 PF00791.20 PIK60303.1 - 0.003 17.9 0.1 0.0088 16.4 0.0 1.8 2 0 0 2 2 2 1 ZU5 domain RVT_1 PF00078.27 PIK60305.1 - 1.1e-26 93.7 0.0 1.4e-26 93.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IalB PF06776.12 PIK60305.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Invasion associated locus B (IalB) protein ZU5 PF00791.20 PIK60306.1 - 3.3e-15 56.2 0.0 1.6e-11 44.4 0.0 2.8 2 0 0 2 2 2 2 ZU5 domain MMR_HSR1 PF01926.23 PIK60307.1 - 0.0088 16.1 0.0 0.099 12.7 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Hormone_recep PF00104.30 PIK60307.1 - 0.032 13.8 0.5 0.06 12.9 0.1 1.6 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor GTP_EFTU PF00009.27 PIK60307.1 - 0.048 13.2 0.1 0.16 11.5 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain F-box-like PF12937.7 PIK60308.1 - 0.00016 21.5 0.9 0.00016 21.5 0.9 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK60308.1 - 0.00048 19.9 0.1 0.0012 18.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain BTK PF00779.19 PIK60308.1 - 0.0069 16.2 1.0 0.0069 16.2 1.0 2.3 2 0 0 2 2 2 1 BTK motif F-box-like PF12937.7 PIK60309.1 - 0.00076 19.3 0.9 0.00076 19.3 0.9 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK60309.1 - 0.0019 18.0 0.1 0.0058 16.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain BTK PF00779.19 PIK60309.1 - 0.01 15.7 1.0 0.029 14.2 1.0 1.8 1 0 0 1 1 1 0 BTK motif NACHT PF05729.12 PIK60310.1 - 4.9e-16 59.1 0.0 1.8e-15 57.2 0.0 2.1 2 0 0 2 2 2 1 NACHT domain DED PF01335.21 PIK60310.1 - 2.6e-06 27.7 0.7 0.043 14.1 0.0 2.9 2 0 0 2 2 2 2 Death effector domain AAA PF00004.29 PIK60310.1 - 0.00069 20.1 0.0 0.0021 18.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 PIK60310.1 - 0.001 18.7 0.0 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK60310.1 - 0.019 14.3 0.0 0.052 12.9 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 PIK60310.1 - 0.11 12.7 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 PIK60310.1 - 0.11 12.4 0.0 0.38 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 PIK60310.1 - 0.14 11.9 0.1 0.99 9.1 0.0 2.3 3 0 0 3 3 3 0 IstB-like ATP binding protein RT_RNaseH_2 PF17919.1 PIK60311.1 - 3.3e-38 129.7 0.0 6.5e-37 125.6 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60311.1 - 2.4e-37 127.4 0.0 1.1e-34 118.9 0.0 2.4 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60311.1 - 3.6e-09 36.5 0.2 8.6e-09 35.2 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Utp14 PF04615.13 PIK60312.1 - 0.033 12.8 15.0 0.04 12.5 15.0 1.1 1 0 0 1 1 1 0 Utp14 protein Dapper PF15268.6 PIK60312.1 - 0.71 8.7 21.9 0.29 9.9 11.3 2.1 2 0 0 2 2 2 0 Dapper CLN3 PF02487.17 PIK60312.1 - 5.5 5.9 6.4 8.3 5.3 6.4 1.3 1 0 0 1 1 1 0 CLN3 protein Lectin_C PF00059.21 PIK60314.1 - 2e-16 60.7 0.7 2.3e-16 60.4 0.7 1.1 1 0 0 1 1 1 1 Lectin C-type domain Acetyltransf_1 PF00583.25 PIK60315.1 - 1.5e-11 44.5 0.0 2.1e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 PIK60315.1 - 2.6e-08 33.9 0.0 3.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 PIK60315.1 - 6.4e-08 32.9 0.0 9e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 PIK60315.1 - 4.2e-07 30.2 0.1 6.2e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 PIK60315.1 - 1.1e-05 25.3 0.0 2.2e-05 24.3 0.0 1.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 PIK60315.1 - 0.0015 19.2 0.0 0.0025 18.5 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 PIK60315.1 - 0.0068 16.5 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 PIK60315.1 - 0.0097 15.6 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Gly_acyl_tr_C PF08444.10 PIK60315.1 - 0.036 14.3 0.1 0.18 12.1 0.0 1.8 1 1 1 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region DUF762 PF05555.11 PIK60315.1 - 0.036 13.6 0.1 0.048 13.2 0.1 1.1 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF762) RL PF17797.1 PIK60315.1 - 0.046 13.7 0.4 0.069 13.1 0.4 1.3 1 0 0 1 1 1 0 RL domain ATP-synt_ab PF00006.25 PIK60316.1 - 7.2e-79 264.4 0.1 1.1e-78 263.8 0.1 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 PIK60316.1 - 1.5e-24 86.2 0.0 2.8e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension Fumble PF03630.14 PIK60316.1 - 0.039 13.1 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 Fumble ATP-synt_ab_N PF02874.23 PIK60316.1 - 0.08 13.5 0.1 0.17 12.4 0.1 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain Pkinase_Tyr PF07714.17 PIK60317.1 - 5e-32 111.2 0.0 7.5e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60317.1 - 5.1e-11 42.4 0.0 8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK60317.1 - 0.00082 19.4 0.4 0.0035 17.4 0.4 2.1 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK60318.1 - 0.0047 16.9 0.0 0.016 15.1 0.0 2.0 1 1 0 1 1 1 1 NACHT domain Lipoprotein_3 PF00938.17 PIK60318.1 - 0.016 15.4 0.3 0.061 13.5 0.3 2.0 1 0 0 1 1 1 0 Lipoprotein NLRC4_HD2 PF17776.1 PIK60318.1 - 0.14 12.7 3.2 2 9.0 0.9 3.1 2 1 0 2 2 2 0 NLRC4 helical domain HD2 NACHT PF05729.12 PIK60320.1 - 0.02 14.8 0.1 0.059 13.3 0.1 1.8 1 1 0 1 1 1 0 NACHT domain NACHT PF05729.12 PIK60322.1 - 6.9e-08 32.6 0.0 1.7e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 NACHT domain ATE_C PF04377.15 PIK60322.1 - 0.067 13.8 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, C terminus SKG6 PF08693.10 PIK60322.1 - 0.074 12.5 7.5 0.14 11.6 7.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MLANA PF14991.6 PIK60322.1 - 0.18 12.1 0.3 0.77 10.1 0.3 2.0 1 0 0 1 1 1 0 Protein melan-A FixS PF03597.15 PIK60322.1 - 0.9 9.3 3.8 1.5 8.6 3.8 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type ig PF00047.25 PIK60324.1 - 0.0018 18.4 4.1 0.24 11.6 0.3 2.4 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK60324.1 - 0.0051 16.9 0.3 0.0051 16.9 0.3 2.3 2 2 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Tropomyosin PF00261.20 PIK60325.1 - 0.0042 16.5 3.9 0.0075 15.7 3.9 1.4 1 0 0 1 1 1 1 Tropomyosin ImcF-related_N PF14331.6 PIK60325.1 - 0.013 14.9 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain Tropomyosin_1 PF12718.7 PIK60325.1 - 0.025 14.7 4.2 0.045 13.9 4.2 1.5 1 0 0 1 1 1 0 Tropomyosin like DUF2730 PF10805.8 PIK60325.1 - 0.035 14.2 2.5 0.082 13.0 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Transposase_22 PF02994.14 PIK60325.1 - 0.043 14.0 1.2 0.18 12.0 1.1 2.2 1 1 0 1 1 1 0 L1 transposable element RBD-like domain Laminin_II PF06009.12 PIK60325.1 - 0.047 13.7 1.2 0.093 12.7 1.2 1.6 1 0 0 1 1 1 0 Laminin Domain II zf-C4H2 PF10146.9 PIK60325.1 - 0.088 13.1 5.2 0.11 12.8 5.2 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Mis12 PF05859.12 PIK60325.1 - 0.13 12.3 2.0 0.32 11.1 2.0 1.6 1 1 0 1 1 1 0 Mis12 protein FlaC_arch PF05377.11 PIK60325.1 - 0.15 12.5 3.0 0.29 11.5 2.1 2.0 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1515 PF07439.11 PIK60325.1 - 0.17 11.9 5.1 0.33 11.0 1.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) DUF1664 PF07889.12 PIK60325.1 - 0.23 11.5 4.1 0.48 10.5 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) KMP11 PF03037.16 PIK60325.1 - 0.27 12.0 2.9 0.93 10.3 2.6 2.0 1 1 0 1 1 1 0 Kinetoplastid membrane protein 11 COG2 PF06148.11 PIK60325.1 - 0.4 10.8 3.7 0.7 10.0 1.5 2.3 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec34 PF04136.15 PIK60325.1 - 0.47 10.3 4.9 0.25 11.2 1.7 2.2 2 1 1 3 3 3 0 Sec34-like family TMF_DNA_bd PF12329.8 PIK60325.1 - 0.51 10.4 5.9 1.3 9.1 5.9 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Herpes_UL14 PF03580.14 PIK60325.1 - 1.1 9.5 6.4 0.41 10.9 2.7 2.0 2 0 0 2 2 2 0 Herpesvirus UL14-like protein Lipoprotein_19 PF13617.6 PIK60326.1 - 6 6.7 5.6 36 4.3 0.6 2.9 3 0 0 3 3 3 0 YnbE-like lipoprotein NACHT PF05729.12 PIK60327.1 - 2.2e-06 27.7 0.0 8.4e-06 25.8 0.0 2.0 1 1 0 1 1 1 1 NACHT domain I-set PF07679.16 PIK60327.1 - 0.0011 19.0 0.1 0.12 12.5 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60327.1 - 0.032 14.8 0.4 1.6 9.4 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain Vps39_1 PF10366.9 PIK60327.1 - 0.041 14.2 0.1 0.19 12.0 0.1 2.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 V-set PF07686.17 PIK60327.1 - 0.05 13.8 0.3 0.14 12.3 0.3 1.8 1 0 0 1 1 1 0 Immunoglobulin V-set domain ig PF00047.25 PIK60327.1 - 0.15 12.2 2.0 11 6.2 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain PIH1_CS PF18201.1 PIK60327.1 - 0.23 11.9 1.1 5 7.6 0.1 2.8 3 0 0 3 3 3 0 PIH1 CS-like domain V-set PF07686.17 PIK60328.1 - 1.5e-06 28.3 0.3 7.8e-06 26.0 0.0 2.2 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK60328.1 - 1.3e-05 25.7 0.4 0.054 14.1 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK60328.1 - 0.00027 21.0 0.0 0.22 11.6 0.0 2.6 2 1 1 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK60328.1 - 0.00099 19.2 0.4 1.9 8.8 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK60328.1 - 0.021 15.2 1.5 0.035 14.5 0.8 1.7 2 0 0 2 2 2 0 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK60328.1 - 0.036 14.1 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain NACHT PF05729.12 PIK60329.1 - 2.6e-06 27.5 0.0 7.6e-06 25.9 0.0 1.8 1 1 0 1 1 1 1 NACHT domain MLANA PF14991.6 PIK60329.1 - 0.072 13.4 0.4 0.22 11.8 0.4 1.8 1 0 0 1 1 1 0 Protein melan-A Mg_trans_NIPA PF05653.14 PIK60329.1 - 0.08 12.0 0.2 0.12 11.5 0.2 1.2 1 0 0 1 1 1 0 Magnesium transporter NIPA Shisa PF13908.6 PIK60329.1 - 0.1 12.8 0.2 0.1 12.8 0.2 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator RCR PF12273.8 PIK60329.1 - 0.11 13.2 0.0 0.37 11.5 0.0 1.9 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TsaE PF02367.17 PIK60329.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TMIE PF16038.5 PIK60329.1 - 0.21 11.4 0.8 0.58 10.0 0.8 1.7 1 0 0 1 1 1 0 TMIE protein Vps39_1 PF10366.9 PIK60330.1 - 0.14 12.5 2.2 3.4 8.0 0.1 2.8 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 Pkinase_Tyr PF07714.17 PIK60331.1 - 1.3e-41 142.6 0.0 2.1e-41 141.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60331.1 - 8.5e-13 48.3 0.0 2.7e-12 46.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60332.1 - 6.1e-41 140.4 0.0 8.1e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60332.1 - 1.9e-15 56.9 0.0 2.2e-14 53.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain DED PF01335.21 PIK60333.1 - 1.1e-06 28.9 0.6 0.0042 17.4 0.1 2.3 2 1 0 2 2 2 2 Death effector domain BORA_N PF15280.6 PIK60333.1 - 0.046 13.4 0.1 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein aurora borealis N-terminus RT_RNaseH PF17917.1 PIK60334.1 - 5.2e-24 84.6 0.0 1.1e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK60334.1 - 1.3e-15 57.3 0.0 2.8e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60334.1 - 4.2e-11 42.8 0.1 1.8e-10 40.7 0.1 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK60335.1 - 8.1e-05 22.8 0.0 0.00018 21.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain ZU5 PF00791.20 PIK60336.1 - 4.4e-15 55.8 0.0 9.3e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK60336.1 - 6e-12 45.6 0.1 1.2e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Death domain Chromo PF00385.24 PIK60338.1 - 1.5e-11 44.0 0.4 3.9e-11 42.7 0.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain GTF2I PF02946.14 PIK60338.1 - 7.2e-09 35.6 0.0 1.9e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 GTF2I-like repeat Tudor-knot PF11717.8 PIK60338.1 - 6.9e-05 22.7 0.1 0.00016 21.5 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 PIK60338.1 - 0.02 15.0 0.3 0.044 13.9 0.3 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Ig_3 PF13927.6 PIK60341.1 - 1.9e-05 25.1 0.0 3.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60341.1 - 0.00021 21.6 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 PIK60341.1 - 0.02 14.4 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_5 PF16681.5 PIK60341.1 - 0.03 14.7 0.0 0.052 14.0 0.0 1.3 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TPR_11 PF13414.6 PIK60341.1 - 0.079 12.7 0.1 1.3 8.7 0.0 2.8 3 0 0 3 3 3 0 TPR repeat Fer4_13 PF13370.6 PIK60341.1 - 0.083 13.4 0.1 22 5.7 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I I-set PF07679.16 PIK60341.1 - 0.089 12.9 0.0 0.22 11.6 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 PIK60341.1 - 0.16 12.1 0.1 0.72 10.1 0.0 1.9 1 1 1 2 2 2 0 Immunoglobulin V-set domain ig PF00047.25 PIK60341.1 - 0.17 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain 7tm_2 PF00002.24 PIK60342.1 - 3.8e-31 108.3 16.3 5e-31 107.9 16.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 PIK60342.1 - 4.3e-05 22.8 11.5 4.3e-05 22.8 11.5 1.3 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor ECSCR PF15820.5 PIK60342.1 - 0.058 13.2 2.9 0.079 12.8 0.3 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator DUF3687 PF12459.8 PIK60342.1 - 8.1 6.0 8.6 0.36 10.4 0.4 2.6 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein MULE PF10551.9 PIK60343.1 - 1e-06 29.1 0.0 1.8e-05 25.1 0.0 2.7 2 1 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.18 PIK60343.1 - 0.052 12.4 0.0 0.086 11.7 0.0 1.2 1 0 0 1 1 1 0 Transposase, Mutator family FANCI_S1 PF14675.6 PIK60343.1 - 0.099 12.2 0.4 17 4.9 0.0 2.7 3 0 0 3 3 3 0 FANCI solenoid 1 Fer2_2 PF01799.20 PIK60345.1 - 3.4e-29 100.7 0.3 8.4e-29 99.4 0.3 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 PIK60345.1 - 5.8e-09 35.8 0.8 5.8e-09 35.8 0.8 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 PIK60345.1 - 0.29 11.2 10.2 0.91 9.6 0.4 2.5 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain OTT_1508_deam PF14441.6 PIK60345.1 - 0.49 10.4 2.6 0.41 10.7 0.1 2.1 2 0 0 2 2 2 0 OTT_1508-like deaminase Ald_Xan_dh_C2 PF02738.18 PIK60346.1 - 4.4e-73 246.6 2.3 1.8e-26 92.8 0.0 4.1 3 1 1 4 4 4 4 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.22 PIK60346.1 - 4.4e-33 113.9 0.3 7.6e-33 113.2 0.3 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain DNA_pol_E_B PF04042.16 PIK60348.1 - 9.6e-26 90.4 0.8 1e-25 90.3 0.8 1.0 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 PIK60350.1 - 1.3e-16 60.6 1.8 9.6e-16 57.9 1.0 2.3 2 0 0 2 2 2 1 DNA polymerases epsilon N terminal BCDHK_Adom3 PF10436.9 PIK60350.1 - 0.096 12.5 0.4 0.14 12.0 0.4 1.3 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase WD40 PF00400.32 PIK60351.1 - 2.1e-08 34.6 12.5 0.0095 16.8 0.0 7.1 8 0 0 8 8 8 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 PIK60351.1 - 2.4e-05 23.3 3.3 0.62 8.7 0.1 4.9 3 2 2 5 5 5 3 Nup133 N terminal like Nup160 PF11715.8 PIK60351.1 - 4.6e-05 22.3 0.8 0.39 9.3 0.1 3.4 3 0 0 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 PIK60352.1 - 2.5e-06 28.1 1.1 0.0045 17.8 0.5 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat HN PF00423.19 PIK60353.1 - 0.028 13.2 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase FAD_binding_5 PF00941.21 PIK60354.1 - 2e-36 125.3 0.0 3.3e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.20 PIK60354.1 - 1.2e-29 102.1 0.1 3e-29 100.9 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 PIK60354.1 - 1.9e-29 102.2 0.1 4.4e-29 101.1 0.1 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 PIK60354.1 - 8.2e-25 87.0 0.0 1.7e-24 85.9 0.0 1.6 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C2 PF02738.18 PIK60354.1 - 2.4e-13 49.4 0.1 3.8e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Fer2 PF00111.27 PIK60354.1 - 6.4e-05 22.8 1.6 0.00013 21.8 0.7 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Ald_Xan_dh_C2 PF02738.18 PIK60355.1 - 7.8e-128 427.3 0.0 9.1e-128 427.1 0.0 1.0 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase zf-H2C2_2 PF13465.6 PIK60357.1 - 4.8e-31 105.8 34.2 2.7e-07 30.7 0.7 6.6 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 PIK60357.1 - 3.8e-26 90.0 37.3 3.9e-07 30.2 0.1 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60357.1 - 3e-19 68.0 36.4 0.0012 19.5 1.4 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK60357.1 - 5.3e-06 26.6 24.7 0.021 15.1 0.3 6.0 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 PIK60357.1 - 0.0019 18.4 20.2 0.2 11.8 0.1 4.7 3 2 1 4 4 4 2 Aberrant zinc-finger zf-C2H2_8 PF15909.5 PIK60357.1 - 0.0039 17.5 14.4 0.16 12.3 3.7 3.5 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-met PF12874.7 PIK60357.1 - 0.019 15.3 26.2 0.38 11.2 1.0 6.5 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-RING_7 PF02591.15 PIK60357.1 - 0.025 14.8 1.8 0.12 12.5 0.2 2.8 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf-C2H2_6 PF13912.6 PIK60357.1 - 0.039 14.0 33.6 0.045 13.8 0.2 5.7 6 0 0 6 6 6 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK60357.1 - 0.18 11.6 0.1 0.18 11.6 0.1 5.8 5 1 0 5 5 5 0 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.5 PIK60357.1 - 0.3 11.8 11.7 0.72 10.6 0.5 2.9 2 1 1 3 3 3 0 zinc-ribbon family zf-C2HC_2 PF13913.6 PIK60357.1 - 0.82 9.6 11.5 4.1 7.4 0.5 4.9 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-DNA_Pol PF08996.10 PIK60357.1 - 2.6 7.7 7.5 4.7 6.9 1.2 2.4 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger CpXC PF14353.6 PIK60357.1 - 5.7 7.0 6.2 11 6.2 0.1 3.2 2 1 1 3 3 3 0 CpXC protein CRM1_C PF08767.11 PIK60358.1 - 4.9e-125 417.0 0.6 4.9e-125 417.0 0.6 3.3 2 1 1 3 3 3 1 CRM1 C terminal CRM1_repeat_2 PF18784.1 PIK60358.1 - 1.5e-35 120.6 3.3 1.5e-35 120.6 3.3 2.2 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 PIK60358.1 - 2.4e-30 104.4 3.0 3.7e-30 103.8 1.0 2.6 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 Xpo1 PF08389.12 PIK60358.1 - 8.6e-26 90.8 8.6 2.4e-25 89.3 1.4 4.0 4 1 0 4 4 4 1 Exportin 1-like protein CRM1_repeat PF18777.1 PIK60358.1 - 2.1e-19 68.7 5.3 4.7e-19 67.6 5.3 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 PIK60358.1 - 1.6e-11 43.9 0.0 1.1e-10 41.3 0.0 2.6 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 PIK60358.1 - 0.0071 16.9 2.0 2.5 8.7 0.1 4.6 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region DUF917 PF06032.12 PIK60359.1 - 1e-88 297.5 3.9 4.3e-47 160.6 0.1 3.2 2 1 1 3 3 3 2 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 PIK60359.1 - 1.2e-33 116.3 4.0 9.1e-32 110.2 0.0 3.2 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 PIK60359.1 - 5.9e-31 107.8 4.6 3.2e-26 92.2 0.1 3.3 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase MutL PF13941.6 PIK60359.1 - 9.1e-06 24.5 1.4 0.0034 16.0 0.1 2.5 2 0 0 2 2 2 2 MutL protein StbA PF06406.11 PIK60359.1 - 0.011 15.0 0.8 0.23 10.6 0.1 2.6 2 0 0 2 2 2 0 StbA protein FtsA PF14450.6 PIK60359.1 - 0.013 15.9 3.6 5 7.6 0.0 3.5 3 1 0 3 3 3 0 Cell division protein FtsA BcrAD_BadFG PF01869.20 PIK60359.1 - 0.32 10.4 2.3 12 5.3 0.0 2.9 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family KDGP_aldolase PF07071.11 PIK60359.1 - 1.3 8.8 4.1 3.7 7.3 0.0 2.6 2 1 1 3 3 3 0 KDGP aldolase ECH_1 PF00378.20 PIK60360.1 - 1.8e-25 89.7 0.0 2.6e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK60360.1 - 3.3e-09 36.7 0.0 5.5e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK60361.1 - 1.3e-30 106.6 0.0 1.6e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK60361.1 - 4.9e-15 55.9 0.0 6.8e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK60362.1 - 0.00022 20.6 0.1 0.00025 20.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK60362.1 - 0.017 15.0 0.1 0.033 14.1 0.1 1.5 1 1 0 1 1 1 0 Peptidase family S49 CBFD_NFYB_HMF PF00808.23 PIK60363.1 - 1.1e-19 70.4 1.0 1.7e-19 69.9 1.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK60363.1 - 2e-06 28.2 0.4 2e-06 28.2 0.4 2.4 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Macoilin PF09726.9 PIK60363.1 - 0.029 13.0 12.2 0.034 12.7 12.2 1.0 1 0 0 1 1 1 0 Macoilin family Pol_alpha_B_N PF08418.10 PIK60363.1 - 0.072 13.0 12.2 0.2 11.6 12.2 1.7 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Myc_N PF01056.18 PIK60363.1 - 0.14 12.0 9.9 0.19 11.6 9.9 1.3 1 1 0 1 1 1 0 Myc amino-terminal region PNISR PF15996.5 PIK60363.1 - 0.23 11.7 9.4 0.34 11.2 9.4 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Pox_Ag35 PF03286.14 PIK60363.1 - 0.24 11.2 8.7 0.35 10.6 8.7 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein KCT2 PF17818.1 PIK60363.1 - 0.34 11.0 8.7 0.63 10.1 8.7 1.4 1 0 0 1 1 1 0 Keratinocyte-associated gene product TMEM215 PF15746.5 PIK60363.1 - 0.49 9.8 4.0 0.65 9.4 4.0 1.2 1 0 0 1 1 1 0 TMEM215 family Hid1 PF12722.7 PIK60363.1 - 0.61 8.1 9.2 0.7 8.0 9.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 PIK60363.1 - 0.99 8.2 6.2 1.2 7.9 6.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NOA36 PF06524.12 PIK60363.1 - 1.1 8.5 9.1 1.6 8.0 9.1 1.3 1 0 0 1 1 1 0 NOA36 protein FancD2 PF14631.6 PIK60363.1 - 1.8 5.8 9.9 1.8 5.8 9.0 1.3 1 1 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Vpu PF00558.19 PIK60363.1 - 1.9 8.3 4.1 4.5 7.1 4.1 1.6 1 0 0 1 1 1 0 Vpu protein SpoIIIAH PF12685.7 PIK60363.1 - 7.5 6.3 13.1 9.7 6.0 13.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein THAP PF05485.12 PIK60365.1 - 2.4e-13 50.8 0.1 6.6e-13 49.4 0.1 1.8 1 0 0 1 1 1 1 THAP domain GCD14_N PF14801.6 PIK60365.1 - 0.15 12.0 0.3 8.4 6.3 0.2 2.5 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit N-term ComP_DUS PF16732.5 PIK60367.1 - 0.032 15.1 0.1 0.05 14.5 0.1 1.3 1 0 0 1 1 1 0 Type IV minor pilin ComP, DNA uptake sequence receptor EF-hand_7 PF13499.6 PIK60369.1 - 6.7e-08 32.9 14.4 0.00067 20.0 0.1 6.3 5 2 1 6 6 6 3 EF-hand domain pair EF-hand_13 PF17958.1 PIK60369.1 - 9.4e-07 28.6 0.1 1.8e-05 24.5 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_6 PF13405.6 PIK60369.1 - 3.4e-05 23.4 10.7 1.3 9.1 0.0 5.5 6 0 0 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 PIK60369.1 - 0.00014 21.1 7.7 0.28 10.8 0.0 5.4 7 0 0 7 7 7 2 EF hand EF-hand_5 PF13202.6 PIK60369.1 - 0.017 14.6 0.4 0.18 11.4 0.0 2.9 3 0 0 3 3 3 0 EF hand 2-Hacid_dh_C PF02826.19 PIK60370.1 - 2.6e-17 62.7 0.0 3.1e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 PIK60370.1 - 0.011 16.2 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PglD_N PF17836.1 PIK60370.1 - 0.013 16.1 0.0 0.021 15.4 0.0 1.3 1 0 0 1 1 1 0 PglD N-terminal domain ThiF PF00899.21 PIK60370.1 - 0.014 14.7 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 ThiF family Pyr_redox_2 PF07992.14 PIK60370.1 - 0.06 12.6 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Dehydratase_LU PF02286.15 PIK60370.1 - 0.075 11.6 0.0 0.094 11.3 0.0 1.1 1 0 0 1 1 1 0 Dehydratase large subunit Shikimate_DH PF01488.20 PIK60370.1 - 0.08 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase WD40 PF00400.32 PIK60371.1 - 8.1e-18 64.5 0.5 1.5e-06 28.8 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat LisH_TPL PF17814.1 PIK60371.1 - 9.9e-13 47.5 0.2 1.8e-12 46.7 0.2 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 PIK60371.1 - 1.7e-10 41.1 0.0 0.00021 21.5 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK60371.1 - 4.8e-08 32.3 0.2 0.0034 16.4 0.0 2.6 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 PIK60371.1 - 0.00096 17.9 0.0 0.2 10.3 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 FOP_dimer PF09398.10 PIK60371.1 - 0.089 13.1 0.0 0.23 11.7 0.0 1.6 2 0 0 2 2 2 0 FOP N terminal dimerisation domain GerA PF03323.13 PIK60371.1 - 0.14 10.6 0.0 0.45 8.9 0.0 1.7 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Hira PF07569.11 PIK60371.1 - 0.14 11.9 0.2 27 4.4 0.0 3.0 3 0 0 3 3 3 0 TUP1-like enhancer of split WD40 PF00400.32 PIK60372.1 - 0.00035 21.3 0.0 0.00096 19.9 0.0 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat RT_RNaseH_2 PF17919.1 PIK60373.1 - 2.3e-18 66.1 0.0 5e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60373.1 - 1e-06 29.0 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK60373.1 - 4.3e-05 23.1 0.0 7.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 PIK60373.1 - 0.0045 17.3 0.0 0.0092 16.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK60373.1 - 0.01 16.4 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK60373.1 - 0.04 14.0 2.0 0.04 14.0 2.0 2.5 2 0 0 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 PIK60373.1 - 0.072 13.7 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease RVP_2 PF08284.11 PIK60373.1 - 0.083 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease EGF PF00008.27 PIK60374.1 - 8e-127 412.9 428.7 4.1e-08 33.4 6.6 28.8 28 1 1 29 29 27 25 EGF-like domain hEGF PF12661.7 PIK60374.1 - 1.5e-72 238.0 357.8 4.8e-07 30.2 4.7 30.3 29 1 0 29 29 28 23 Human growth factor-like EGF Ank_2 PF12796.7 PIK60374.1 - 2.2e-26 92.3 3.1 6.1e-11 42.8 0.1 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) EGF_CA PF07645.15 PIK60374.1 - 2.3e-24 85.3 425.7 5e-05 23.4 7.0 27.7 11 8 16 27 27 24 15 Calcium-binding EGF domain Ank_4 PF13637.6 PIK60374.1 - 7.1e-20 71.1 0.3 4.3e-06 27.2 0.0 5.2 3 1 1 4 4 4 4 Ankyrin repeats (many copies) EGF_2 PF07974.13 PIK60374.1 - 8.7e-20 70.8 457.2 0.00023 21.5 7.6 28.3 28 1 0 28 28 26 18 EGF-like domain Ank_3 PF13606.6 PIK60374.1 - 6.7e-19 66.0 1.8 0.00018 21.7 0.0 6.6 6 0 0 6 6 5 4 Ankyrin repeat Ank PF00023.30 PIK60374.1 - 4.2e-16 58.6 2.5 0.00022 21.5 0.2 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 PIK60374.1 - 8.3e-14 51.5 0.4 2.6e-05 24.4 0.0 4.3 2 2 1 3 3 3 3 Ankyrin repeats (many copies) DUF3454 PF11936.8 PIK60374.1 - 3e-08 34.0 14.2 3e-08 34.0 14.2 2.6 2 0 0 2 2 1 1 Domain of unknown function (DUF3454) NOD PF06816.13 PIK60374.1 - 0.00026 20.5 0.0 0.00041 19.9 0.0 1.3 1 0 0 1 1 1 1 NOTCH protein NODP PF07684.12 PIK60374.1 - 0.00027 21.0 0.6 0.0016 18.6 0.0 2.8 2 0 0 2 2 1 1 NOTCH protein cEGF PF12662.7 PIK60374.1 - 0.0029 17.5 10.3 0.0048 16.8 1.6 25.8 24 4 0 24 24 22 9 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK60374.1 - 0.0072 16.5 3.8 0.0072 16.5 3.8 27.9 22 5 4 26 26 25 12 EGF domain EGF PF00008.27 PIK60375.1 - 6.3e-26 90.3 63.3 1e-08 35.3 8.0 5.3 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 PIK60375.1 - 4.2e-16 58.9 48.0 1.3e-05 25.6 5.9 5.5 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_CA PF07645.15 PIK60375.1 - 3e-10 40.1 63.9 1.2e-07 31.8 10.6 5.8 4 1 1 5 5 5 4 Calcium-binding EGF domain EGF_2 PF07974.13 PIK60375.1 - 3.7e-07 30.4 69.2 0.0067 16.8 10.3 5.0 5 0 0 5 5 5 4 EGF-like domain EGF_3 PF12947.7 PIK60375.1 - 0.00086 19.5 26.1 0.0048 17.1 7.9 5.3 4 1 1 5 5 5 3 EGF domain FXa_inhibition PF14670.6 PIK60375.1 - 0.007 16.6 53.5 0.37 11.1 10.6 5.0 2 1 3 5 5 5 3 Coagulation Factor Xa inhibitory site HAUS-augmin3 PF14932.6 PIK60376.1 - 0.0024 17.5 0.7 0.0026 17.4 0.7 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 SUZ PF12752.7 PIK60376.1 - 0.0055 17.4 2.6 0.033 15.0 0.6 2.3 2 0 0 2 2 2 1 SUZ domain DUF5526 PF17664.1 PIK60376.1 - 0.0089 15.6 2.0 0.0089 15.6 2.0 1.7 2 1 0 2 2 2 1 Family of unknown function (DUF5526) Filament PF00038.21 PIK60376.1 - 0.012 15.2 1.7 0.014 15.0 1.7 1.1 1 0 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.11 PIK60376.1 - 0.016 14.1 1.1 0.02 13.8 1.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 PIK60376.1 - 0.026 14.6 1.2 0.028 14.5 1.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 PIK60376.1 - 0.028 14.6 2.0 0.037 14.3 2.0 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FapA PF03961.13 PIK60376.1 - 0.029 13.0 1.6 0.029 13.0 1.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Phage_GPO PF05929.11 PIK60376.1 - 0.033 13.8 0.6 0.041 13.5 0.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HIP1_clath_bdg PF16515.5 PIK60376.1 - 0.06 14.0 2.0 0.092 13.4 2.0 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_TATA_bd PF12325.8 PIK60376.1 - 0.063 13.5 2.2 0.15 12.3 2.2 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 PIK60376.1 - 0.11 12.5 3.6 1.7 8.7 2.8 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PKcGMP_CC PF16808.5 PIK60376.1 - 0.15 11.9 7.8 0.8 9.6 0.8 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF5082 PF16888.5 PIK60376.1 - 0.18 12.1 3.7 5.3 7.3 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Spc42p PF11544.8 PIK60376.1 - 0.22 11.5 3.3 2.7 8.0 0.5 2.3 1 1 1 2 2 2 0 Spindle pole body component Spc42p SlyX PF04102.12 PIK60376.1 - 0.24 12.1 4.6 3.1 8.5 0.1 2.2 1 1 0 1 1 1 0 SlyX Csm1_N PF18504.1 PIK60376.1 - 0.58 10.5 4.4 1.2 9.5 0.7 2.3 1 1 0 2 2 2 0 Csm1 N-terminal domain DUF4140 PF13600.6 PIK60376.1 - 0.89 10.0 3.6 1.4 9.4 0.8 2.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 PIK60376.1 - 3.4 7.5 7.2 13 5.6 1.9 2.1 1 1 1 2 2 2 0 Septum formation initiator CLZ PF16526.5 PIK60377.1 - 0.87 10.0 9.9 0.68 10.3 2.2 2.4 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LMBR1 PF04791.16 PIK60377.1 - 1.2 7.9 7.7 1.4 7.7 7.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 PIK60377.1 - 1.7 9.0 19.4 2.2 8.6 18.7 1.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) V_ATPase_I PF01496.19 PIK60378.1 - 0.12 10.3 4.1 0.13 10.1 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fez1 PF06818.15 PIK60378.1 - 0.13 12.7 9.2 0.2 12.1 9.2 1.3 1 0 0 1 1 1 0 Fez1 Fzo_mitofusin PF04799.13 PIK60378.1 - 0.14 11.7 2.5 0.28 10.7 2.5 1.4 1 0 0 1 1 1 0 fzo-like conserved region DivIC PF04977.15 PIK60378.1 - 0.15 11.9 2.6 2.3 8.0 2.0 2.5 2 0 0 2 2 2 0 Septum formation initiator DUF4164 PF13747.6 PIK60378.1 - 0.15 12.3 6.0 0.58 10.5 6.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) CENP-F_leu_zip PF10473.9 PIK60378.1 - 1.5 8.8 18.3 2.2 8.3 13.6 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YabA PF06156.13 PIK60378.1 - 2.3 8.9 6.7 4.2 8.1 6.7 1.5 1 0 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 PIK60378.1 - 5.6 7.5 13.5 10 6.7 13.5 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF812 PF05667.11 PIK60378.1 - 6 5.6 11.5 8.5 5.1 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4430 PF14478.6 PIK60379.1 - 5.3e-10 39.8 0.2 0.014 15.9 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function (DUF4430) tRNA-synt_2c PF01411.19 PIK60379.1 - 0.019 13.5 0.1 1.8 7.0 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II (A) DUF4430 PF14478.6 PIK60380.1 - 1e-10 42.0 0.0 0.013 16.0 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function (DUF4430) tRNA-synt_2c PF01411.19 PIK60380.1 - 0.024 13.2 0.1 1.6 7.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II (A) Cobalamin_bind PF01122.19 PIK60381.1 - 0.00034 19.6 0.2 0.0017 17.3 0.2 1.8 1 1 0 1 1 1 1 Eukaryotic cobalamin-binding protein Phospholip_A2_1 PF00068.19 PIK60382.1 - 1.4e-10 41.6 0.2 1.8e-10 41.3 0.2 1.1 1 0 0 1 1 1 1 Phospholipase A2 Adap_comp_sub PF00928.21 PIK60383.1 - 4.1e-54 183.7 0.0 6.8e-52 176.4 0.0 2.1 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 PIK60383.1 - 3.9e-08 33.3 0.4 7.2e-08 32.5 0.4 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Sec6 PF06046.13 PIK60383.1 - 0.17 10.2 0.4 0.25 9.7 0.4 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec6 ABC_membrane PF00664.23 PIK60384.1 - 7.9e-12 45.4 14.4 4.6e-09 36.3 6.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_membrane PF00664.23 PIK60385.1 - 4.6e-36 124.9 9.1 5.4e-36 124.7 9.1 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region VMA21 PF09446.10 PIK60385.1 - 0.066 13.3 0.5 0.066 13.3 0.5 2.9 3 0 0 3 3 3 0 VMA21-like domain ABC_tran PF00005.27 PIK60386.1 - 2.9e-26 92.6 0.1 6e-26 91.6 0.0 1.6 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 PIK60386.1 - 2.9e-07 30.2 0.3 0.0027 17.2 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 PIK60386.1 - 0.00039 20.8 0.1 0.0015 19.0 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 PIK60386.1 - 0.00062 19.9 0.1 0.0014 18.7 0.1 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 PIK60386.1 - 0.00099 19.2 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 PIK60386.1 - 0.0029 17.4 0.6 0.99 9.1 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 PIK60386.1 - 0.0084 15.3 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 PIK60386.1 - 0.0084 16.4 0.5 0.18 12.0 0.5 2.5 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 PIK60386.1 - 0.0099 15.1 1.3 0.42 9.7 0.1 2.5 2 1 1 3 3 3 1 NB-ARC domain HIP1_clath_bdg PF16515.5 PIK60386.1 - 0.018 15.7 0.5 0.037 14.6 0.5 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_23 PF13476.6 PIK60386.1 - 0.018 15.6 0.9 0.27 11.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 PIK60386.1 - 0.035 13.8 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 PIK60386.1 - 0.04 13.6 0.1 0.51 10.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 PIK60386.1 - 0.043 13.7 0.3 0.19 11.6 0.1 2.0 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 PIK60386.1 - 0.05 13.6 0.1 10 6.1 0.0 2.9 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 PIK60386.1 - 0.068 12.9 1.0 0.25 11.0 0.2 1.9 2 0 0 2 2 2 0 Guanylate kinase AAA_PrkA PF08298.11 PIK60386.1 - 0.13 11.1 0.0 0.65 8.8 0.0 1.9 2 0 0 2 2 2 0 PrkA AAA domain AIG1 PF04548.16 PIK60386.1 - 0.26 10.6 1.9 1.4 8.2 0.0 2.2 2 1 0 2 2 2 0 AIG1 family CreA PF05981.12 PIK60387.1 - 0.035 14.1 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 CreA protein Inj_translocase PF16928.5 PIK60387.1 - 0.077 12.4 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome Exo_endo_phos_2 PF14529.6 PIK60388.1 - 1.2e-09 38.0 0.1 1.8e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK60388.1 - 2.3e-05 24.0 0.2 3.3e-05 23.5 0.2 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 PIK60389.1 - 1.9e-14 53.8 9.2 0.012 16.4 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60389.1 - 1.1e-06 28.8 0.5 0.032 14.5 0.0 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK60389.1 - 7.7e-05 21.5 0.3 0.4 9.2 0.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 DUF1513 PF07433.11 PIK60389.1 - 0.044 12.9 0.1 5.9 5.9 0.0 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1513) GGACT PF06094.12 PIK60392.1 - 0.026 15.1 0.0 0.038 14.6 0.0 1.3 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like SH3_1 PF00018.28 PIK60393.1 - 4.5e-16 58.2 0.3 3.4e-13 49.0 0.1 2.2 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 PIK60393.1 - 5.8e-13 48.5 0.2 2.4e-12 46.5 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK60393.1 - 1.8e-11 43.6 0.1 3.8e-11 42.5 0.1 1.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK60394.1 - 2.5e-35 119.8 5.2 9.1e-11 41.2 0.2 3.3 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 PIK60394.1 - 1.8e-25 88.5 3.7 5.8e-10 38.9 0.3 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 PIK60394.1 - 3.1e-24 84.4 0.5 5.4e-07 29.2 0.0 3.3 3 0 0 3 3 3 3 Variant SH3 domain Guanylate_cyc PF00211.20 PIK60395.1 - 7.1e-13 48.6 0.0 8.3e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Apt1 PF10351.9 PIK60397.1 - 2.2 7.1 12.6 0.059 12.2 2.0 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain MOR2-PAG1_C PF14225.6 PIK60398.1 - 4.8e-50 170.8 0.7 9.9e-50 169.8 0.1 1.9 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_N PF14222.6 PIK60399.1 - 1.2e-109 367.8 2.7 1.5e-69 235.4 0.6 3.1 1 1 2 3 3 3 3 Cell morphogenesis N-terminal HEAT_2 PF13646.6 PIK60399.1 - 0.0062 16.9 0.2 0.17 12.3 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats Glycos_transf_2 PF00535.26 PIK60400.1 - 3.4e-32 111.6 0.0 4e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 PIK60400.1 - 0.17 11.3 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Ricin_B_lectin PF00652.22 PIK60401.1 - 7.6e-22 77.9 0.7 1e-21 77.5 0.7 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 PIK60401.1 - 3.6e-05 23.3 0.8 6.8e-05 22.5 0.8 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase CDtoxinA PF03498.14 PIK60401.1 - 0.0014 18.3 0.9 0.057 13.0 0.1 2.3 1 1 0 2 2 2 2 Cytolethal distending toxin A/C domain Exo_endo_phos PF03372.23 PIK60402.1 - 3e-16 59.7 0.0 7e-16 58.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 PIK60402.1 - 0.011 15.6 0.0 0.036 13.9 0.0 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase LRR_8 PF13855.6 PIK60404.1 - 3e-13 49.3 17.1 3.7e-08 33.0 1.8 2.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 PIK60404.1 - 5.3e-11 42.6 24.4 1e-05 25.7 3.6 4.1 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK60404.1 - 6.9e-06 25.7 11.1 0.009 16.0 0.4 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.6 PIK60404.1 - 3.4e-05 23.4 9.7 6.2e-05 22.6 5.1 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 PIK60404.1 - 0.00049 20.3 15.5 1.5 9.7 0.1 5.8 5 1 0 5 5 5 2 Leucine Rich Repeat Sec23_helical PF04815.15 PIK60404.1 - 0.0023 17.7 0.9 0.0098 15.7 0.1 2.2 1 1 1 2 2 2 1 Sec23/Sec24 helical domain AFOR_C PF01314.18 PIK60404.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 eIF_4EBP PF05456.11 PIK60405.1 - 2.9e-21 75.5 0.6 2.9e-21 75.5 0.6 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) eIF_4G1 PF12152.8 PIK60405.1 - 0.0096 16.1 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Collagen PF01391.18 PIK60406.1 - 4.9e-25 87.1 99.9 4.3e-09 36.0 27.3 5.1 3 1 2 5 5 5 4 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK60407.1 - 7.2e-45 150.6 140.4 7.8e-11 41.6 25.9 6.2 2 2 4 6 6 6 6 Collagen triple helix repeat (20 copies) Forkhead PF00250.18 PIK60408.1 - 4.5e-12 46.1 1.7 9.6e-12 45.0 1.7 1.6 1 0 0 1 1 1 1 Forkhead domain Attractin PF08037.11 PIK60408.1 - 0.037 14.0 1.0 0.11 12.5 1.0 1.9 1 0 0 1 1 1 0 Attractin family Alpha-2-MRAP_C PF06401.11 PIK60409.1 - 7.9e-35 120.7 27.5 7.8e-31 107.7 17.9 2.1 2 0 0 2 2 2 2 Alpha-2-macroglobulin RAP, C-terminal domain Spc7 PF08317.11 PIK60409.1 - 0.023 13.6 27.8 0.99 8.2 0.4 4.0 3 1 1 4 4 4 0 Spc7 kinetochore protein MAAL_N PF05034.13 PIK60409.1 - 0.026 14.2 1.4 0.35 10.5 0.1 2.7 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase N-terminus COMM_domain PF07258.14 PIK60409.1 - 0.19 11.8 4.7 2.8 8.1 0.1 2.9 3 0 0 3 3 3 0 COMM domain UPF0449 PF15136.6 PIK60409.1 - 1.1 9.8 12.4 0.86 10.1 2.8 3.2 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 FlaC_arch PF05377.11 PIK60409.1 - 2.4 8.6 10.4 1.9 8.9 0.1 3.7 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Lyase_8_N PF08124.11 PIK60409.1 - 3 6.7 6.8 2.1 7.2 0.1 2.6 2 1 1 3 3 3 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF4407 PF14362.6 PIK60409.1 - 6.2 6.1 12.7 1.9 7.8 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) LRR_8 PF13855.6 PIK60410.1 - 6.4e-11 41.8 5.6 0.0013 18.5 0.0 3.3 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 PIK60410.1 - 2.2e-05 24.7 9.6 0.023 15.1 1.4 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK60410.1 - 0.003 17.5 0.2 1 9.4 0.3 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK60410.1 - 0.072 13.7 14.1 11 7.0 0.0 5.2 5 1 0 5 5 5 0 Leucine Rich Repeat RVT_1 PF00078.27 PIK60411.1 - 2.1e-23 83.0 0.1 3.5e-23 82.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK60411.1 - 5.3e-16 58.5 0.0 1.1e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60411.1 - 5.2e-09 36.3 0.0 1.5e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HxlR PF01638.17 PIK60411.1 - 0.064 13.1 0.2 1.2 9.0 0.0 2.7 3 0 0 3 3 3 0 HxlR-like helix-turn-helix DUF4542 PF15075.6 PIK60411.1 - 0.14 12.5 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) WAPL PF07814.13 PIK60412.1 - 1.3e-68 231.5 8.7 1.3e-68 231.5 8.7 1.9 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin WAPL PF07814.13 PIK60413.1 - 1.4e-35 122.8 5.0 1.7e-35 122.5 5.0 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Wap1 PF16997.5 PIK60413.1 - 0.00094 18.4 3.3 0.0014 17.9 3.2 1.3 1 1 0 1 1 1 1 Wap1 domain Atx10homo_assoc PF09759.9 PIK60413.1 - 0.0024 17.8 2.1 1 9.4 0.1 3.0 2 1 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Ank_2 PF12796.7 PIK60415.1 - 1.9e-135 441.8 26.4 4.2e-16 59.3 0.1 12.0 2 2 8 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK60415.1 - 2.6e-112 365.9 7.9 2.5e-12 47.0 0.0 15.6 8 4 9 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.30 PIK60415.1 - 5.2e-104 336.6 34.7 5.1e-07 29.8 0.0 21.2 20 1 0 20 20 20 19 Ankyrin repeat Ank_3 PF13606.6 PIK60415.1 - 1.1e-100 317.3 17.5 2.1e-05 24.6 0.0 21.6 21 1 1 22 22 22 20 Ankyrin repeat Ank_5 PF13857.6 PIK60415.1 - 3.2e-87 285.4 23.0 2.2e-09 37.4 0.1 19.0 6 4 13 19 19 19 18 Ankyrin repeats (many copies) KH_1 PF00013.29 PIK60415.1 - 2.1e-14 53.1 2.4 6.3e-14 51.5 2.4 1.9 1 0 0 1 1 1 1 KH domain Vta1 PF04652.16 PIK60415.1 - 0.062 13.3 5.3 3 7.8 0.0 3.2 3 0 0 3 3 3 0 Vta1 like KH_4 PF13083.6 PIK60415.1 - 0.081 12.8 0.9 0.86 9.5 0.0 3.3 4 0 0 4 4 4 0 KH domain eIF-3c_N PF05470.12 PIK60415.1 - 0.47 8.7 15.2 0.94 7.7 15.2 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus LMBR1 PF04791.16 PIK60415.1 - 7.9 5.2 5.4 17 4.1 5.4 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein RNA_pol_Rpb1_5 PF04998.17 PIK60416.1 - 3.3e-76 256.2 0.2 6.4e-76 255.3 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 PIK60416.1 - 4.7e-73 244.9 0.0 8.6e-73 244.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_4 PF05000.17 PIK60416.1 - 5.9e-32 109.8 0.0 1.6e-31 108.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 PIK60416.1 - 1.3e-30 106.4 0.0 6e-30 104.3 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 PIK60416.1 - 6.8e-23 81.5 2.5 4e-18 65.8 0.0 2.5 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 1 Metallophos PF00149.28 PIK60417.1 - 6.9e-24 85.5 0.0 1.1e-23 84.8 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 PIK60417.1 - 0.034 13.9 1.1 1.5 8.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) DivIC PF04977.15 PIK60418.1 - 0.33 10.8 4.3 0.42 10.4 1.2 2.5 1 1 2 3 3 3 0 Septum formation initiator APG6_N PF17675.1 PIK60418.1 - 0.37 11.3 8.4 1.1 9.8 8.2 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region SlyX PF04102.12 PIK60418.1 - 0.39 11.4 5.0 14 6.4 0.0 3.1 1 1 2 3 3 3 0 SlyX bZIP_1 PF00170.21 PIK60418.1 - 0.48 10.5 10.8 1.1 9.4 0.1 3.7 3 1 1 4 4 4 0 bZIP transcription factor HALZ PF02183.18 PIK60418.1 - 1.4 9.2 6.7 10 6.5 0.2 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper ZapB PF06005.12 PIK60418.1 - 9.4 6.8 11.5 18 5.9 4.9 3.0 2 1 0 2 2 2 0 Cell division protein ZapB CH PF00307.31 PIK60419.1 - 0.036 14.2 2.4 0.55 10.4 0.6 2.8 2 1 1 3 3 3 0 Calponin homology (CH) domain Pkinase PF00069.25 PIK60420.1 - 4e-40 137.8 0.0 8e-40 136.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60420.1 - 7.9e-18 64.7 0.0 1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK60420.1 - 0.00054 20.0 0.1 0.00082 19.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 PIK60420.1 - 0.0025 17.4 0.2 0.0041 16.7 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 PIK60420.1 - 0.0034 16.8 0.1 0.0052 16.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK60420.1 - 0.016 14.5 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 PIK60420.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PDE8 PF08629.10 PIK60421.1 - 0.029 14.4 0.4 0.29 11.2 0.0 2.3 2 0 0 2 2 2 0 PDE8 phosphodiesterase ODV-E18 PF10717.9 PIK60421.1 - 0.03 14.2 0.0 0.072 13.0 0.0 1.7 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 HORMA PF02301.18 PIK60422.1 - 1.9e-13 50.5 0.4 3.5e-13 49.7 0.4 1.4 1 1 0 1 1 1 1 HORMA domain ATG13 PF10033.9 PIK60422.1 - 0.0007 19.4 0.3 0.0017 18.1 0.1 1.7 1 1 1 2 2 2 1 Autophagy-related protein 13 RVT_1 PF00078.27 PIK60423.1 - 5.7e-17 62.0 0.0 1.6e-16 60.5 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK60423.1 - 3.4e-05 23.6 0.0 8.2e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-CCHC_3 PF13917.6 PIK60423.1 - 0.00016 21.5 0.0 0.00044 20.2 0.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK60423.1 - 0.0013 18.8 3.3 0.002 18.1 3.3 1.3 1 0 0 1 1 1 1 Zinc knuckle FYVE PF01363.21 PIK60424.1 - 1.7e-19 69.7 9.2 1.7e-19 69.7 9.2 1.8 2 0 0 2 2 2 1 FYVE zinc finger Arm PF00514.23 PIK60424.1 - 3.1e-11 42.9 15.5 0.033 14.2 0.1 5.7 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat DUF1120 PF06551.12 PIK60424.1 - 0.052 13.7 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1120) IBR PF01485.21 PIK60424.1 - 0.37 11.1 11.4 0.82 9.9 11.4 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 PIK60424.1 - 0.4 10.9 8.1 1.1 9.5 8.1 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger Peptidase_C48 PF02902.19 PIK60425.1 - 2.6e-06 27.4 0.6 5.6e-06 26.3 0.6 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Acetyltransf_14 PF03421.16 PIK60425.1 - 0.0014 18.7 0.1 0.0026 17.8 0.1 1.4 1 0 0 1 1 1 1 YopJ Serine/Threonine acetyltransferase Macoilin PF09726.9 PIK60425.1 - 0.12 10.9 2.2 0.12 10.9 2.2 1.1 1 0 0 1 1 1 0 Macoilin family Podoplanin PF05808.11 PIK60425.1 - 2.6 8.1 5.6 4.2 7.5 5.6 1.3 1 0 0 1 1 1 0 Podoplanin RVT_1 PF00078.27 PIK60426.1 - 5.7e-17 62.0 0.1 1.6e-16 60.5 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med18 PF09637.10 PIK60426.1 - 0.021 14.7 0.2 0.05 13.4 0.0 1.5 2 0 0 2 2 2 0 Med18 protein RVT_1 PF00078.27 PIK60427.1 - 6.9e-09 35.5 0.0 9.8e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK60428.1 - 2.7e-23 81.9 0.0 3.5e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60428.1 - 7.2e-12 45.5 0.0 1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK60429.1 - 5.1e-22 78.3 0.0 9.7e-21 74.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60429.1 - 2e-17 63.0 0.6 3.9e-17 62.1 0.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK60429.1 - 0.00048 19.8 0.0 0.0028 17.4 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK60429.1 - 0.039 14.2 0.8 0.08 13.2 0.8 1.5 1 0 0 1 1 1 0 H2C2 zinc finger HR1 PF02185.16 PIK60430.1 - 1.4e-05 25.1 0.4 2.7e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 Hr1 repeat MtrG PF04210.13 PIK60430.1 - 0.0047 16.7 0.4 4.4 7.2 0.1 2.4 2 0 0 2 2 2 2 Tetrahydromethanopterin S-methyltransferase, subunit G Fungal_TACC PF12709.7 PIK60430.1 - 0.013 15.9 1.7 0.013 15.9 1.7 1.9 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Uds1 PF15456.6 PIK60430.1 - 0.058 13.6 1.3 0.16 12.1 1.3 1.8 1 1 0 1 1 1 0 Up-regulated During Septation Fibrinogen_C PF00147.18 PIK60432.1 - 2.9e-77 259.4 9.8 3.6e-77 259.1 9.8 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain YojJ PF10372.9 PIK60432.1 - 0.029 14.4 0.2 0.049 13.7 0.2 1.3 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Fibrinogen_C PF00147.18 PIK60433.1 - 1.9e-56 191.3 8.9 1.9e-56 191.3 8.9 1.9 2 0 0 2 2 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RRN3 PF05327.11 PIK60433.1 - 0.0058 15.2 13.9 0.0071 14.9 13.9 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 PIK60433.1 - 0.0081 14.4 15.2 0.011 14.1 15.2 1.1 1 0 0 1 1 1 1 Nop14-like family DNA_pol_phi PF04931.13 PIK60433.1 - 0.027 12.6 32.7 0.036 12.2 32.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4211 PF13926.6 PIK60433.1 - 0.12 12.4 7.3 2.2 8.3 5.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4211) DUF4637 PF15470.6 PIK60433.1 - 0.22 11.2 5.5 0.34 10.6 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SAPS PF04499.15 PIK60433.1 - 0.25 10.1 1.9 0.31 9.8 1.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 PIK60433.1 - 0.34 9.1 16.5 0.47 8.7 16.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 PIK60433.1 - 0.55 10.1 15.1 0.9 9.4 15.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region TRAP_alpha PF03896.16 PIK60433.1 - 0.56 9.4 13.2 0.8 8.9 13.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2796 PF10986.8 PIK60433.1 - 0.66 9.9 5.8 1.1 9.2 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Mpp10 PF04006.12 PIK60433.1 - 1 7.7 14.9 1.4 7.3 14.9 1.1 1 0 0 1 1 1 0 Mpp10 protein TFB6 PF17110.5 PIK60433.1 - 1.6 8.5 13.1 3.2 7.5 13.1 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2457 PF10446.9 PIK60433.1 - 1.8 7.6 40.0 2.6 7.1 40.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.12 PIK60433.1 - 3.6 6.9 20.2 5.2 6.4 20.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 PIK60433.1 - 6.7 5.9 35.5 14 4.9 35.5 1.5 1 0 0 1 1 1 0 NOA36 protein SGT1 PF07093.11 PIK60433.1 - 8.1 4.7 15.6 11 4.3 15.6 1.1 1 0 0 1 1 1 0 SGT1 protein CNDH2_C PF16858.5 PIK60433.1 - 8.7 6.1 11.9 12 5.7 11.9 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NPR3 PF03666.13 PIK60433.1 - 9.1 5.0 6.8 13 4.5 6.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAM_1 PF00536.30 PIK60434.1 - 1.3e-18 67.2 1.3 5.8e-12 45.9 0.1 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) PID PF00640.23 PIK60434.1 - 2.2e-18 66.6 0.6 5.7e-18 65.3 0.6 1.7 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SAM_2 PF07647.17 PIK60434.1 - 1.1e-15 57.5 1.0 9.2e-07 28.9 0.0 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) PID_2 PF14719.6 PIK60434.1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) NAM-associated PF14303.6 PIK60435.1 - 0.16 12.7 1.2 0.27 12.0 1.2 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Ank_5 PF13857.6 PIK60436.1 - 9.1e-40 134.2 2.5 1.6e-11 44.2 0.0 6.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK60436.1 - 2.1e-39 133.4 0.2 4.2e-09 36.8 0.0 5.6 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK60436.1 - 1.9e-37 127.7 0.2 8.3e-13 48.7 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK60436.1 - 4.6e-36 118.7 1.1 4.4e-07 29.7 0.1 6.4 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 PIK60436.1 - 6.4e-33 111.8 3.7 1.4e-05 25.3 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat CD20 PF04103.15 PIK60438.1 - 3e-05 24.2 11.0 6.6e-05 23.0 11.0 1.7 1 1 0 1 1 1 1 CD20-like family DUF4118 PF13493.6 PIK60438.1 - 0.012 15.4 0.8 0.028 14.2 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) CD20 PF04103.15 PIK60439.1 - 1.6e-06 28.3 12.1 3e-06 27.4 12.1 1.4 1 1 0 1 1 1 1 CD20-like family DUF4064 PF13273.6 PIK60439.1 - 0.0048 17.2 1.7 0.0048 17.2 1.7 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF4064) Chorein_N PF12624.7 PIK60440.1 - 6.8e-15 55.2 0.1 7.3e-15 55.1 0.1 1.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Ric8 PF10165.9 PIK60443.1 - 3.6e-39 135.1 0.6 4e-39 134.9 0.6 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn YopE_N PF09020.10 PIK60443.1 - 0.16 12.3 0.0 0.2 11.9 0.0 1.1 1 0 0 1 1 1 0 YopE, N terminal DASH_Spc19 PF08287.11 PIK60444.1 - 0.088 12.7 2.6 0.17 11.8 2.6 1.4 1 0 0 1 1 1 0 Spc19 HOOK PF05622.12 PIK60447.1 - 0.0022 16.2 3.9 0.0025 16.0 3.9 1.1 1 0 0 1 1 1 1 HOOK protein APG6_N PF17675.1 PIK60447.1 - 0.0081 16.7 5.8 0.011 16.3 5.8 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region AbiGi PF10899.8 PIK60447.1 - 0.12 12.2 0.6 0.16 11.8 0.6 1.1 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin EamA PF00892.20 PIK60448.1 - 7.7e-15 55.3 19.4 2e-13 50.7 18.3 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 PIK60448.1 - 0.0093 15.3 5.2 0.013 14.8 5.2 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family WD40 PF00400.32 PIK60449.1 - 0.0019 19.0 4.1 1.7 9.7 0.2 3.1 3 1 1 4 4 4 2 WD domain, G-beta repeat Lactonase PF10282.9 PIK60449.1 - 0.027 13.7 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller PH_4 PF15404.6 PIK60449.1 - 0.14 12.0 0.6 4.9 6.9 0.1 2.1 1 1 1 2 2 2 0 Pleckstrin homology domain WD40 PF00400.32 PIK60450.1 - 0.0043 17.9 0.0 0.0066 17.3 0.0 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK60450.1 - 0.01 14.8 0.0 0.012 14.6 0.0 1.1 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cullin_binding PF03556.15 PIK60452.1 - 4.1e-39 133.7 1.5 5.7e-39 133.3 1.5 1.2 1 0 0 1 1 1 1 Cullin binding Kelch_1 PF01344.25 PIK60453.1 - 1.3e-35 120.7 18.0 6.2e-12 44.9 0.1 6.3 7 1 0 7 7 7 4 Kelch motif BTB PF00651.31 PIK60453.1 - 2.3e-27 95.4 0.7 4.8e-27 94.4 0.7 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 PIK60453.1 - 1.3e-26 92.0 8.5 1e-09 38.3 0.0 6.0 4 2 2 6 6 6 4 Kelch motif BACK PF07707.15 PIK60453.1 - 3.4e-23 81.7 1.8 3.4e-23 81.7 1.8 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 PIK60453.1 - 6.9e-18 63.9 4.4 7.8e-05 22.5 0.0 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 PIK60453.1 - 3.9e-16 58.8 5.2 1.1e-06 28.6 0.1 5.5 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 PIK60453.1 - 1.7e-14 53.7 1.9 1.5e-07 31.5 0.1 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK60453.1 - 2.5e-12 46.5 1.3 0.00067 19.6 0.0 4.5 5 0 0 5 5 5 3 Kelch motif DUF3342 PF11822.8 PIK60453.1 - 6.5e-06 26.3 0.1 1.6e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Rhomboid PF01694.22 PIK60454.1 - 6e-10 39.3 2.5 7.8e-10 38.9 2.5 1.1 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 PIK60454.1 - 0.17 12.4 1.2 0.27 11.8 1.2 1.3 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) Glyco_transf_10 PF00852.19 PIK60455.1 - 2e-54 184.0 0.4 3.5e-54 183.2 0.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK60455.1 - 1.2e-05 25.7 0.3 4.7e-05 23.8 0.2 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal SAP PF02037.27 PIK60456.1 - 5.7e-11 41.9 0.5 5.7e-11 41.9 0.5 1.7 2 0 0 2 2 2 1 SAP domain HeH PF12949.7 PIK60456.1 - 0.0013 18.4 1.2 0.0027 17.4 1.2 1.6 1 0 0 1 1 1 1 HeH/LEM domain CSN5_C PF18323.1 PIK60456.1 - 1.7 9.6 5.5 6.9 7.7 4.0 2.1 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain DUF382 PF04037.13 PIK60457.1 - 4.9e-58 194.8 3.2 4.9e-58 194.8 3.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 PIK60457.1 - 4.1e-20 71.4 2.9 4.1e-20 71.4 2.9 2.8 3 0 0 3 3 3 1 PSP DDE_Tnp_1_7 PF13843.6 PIK60458.1 - 4.4e-57 194.0 0.4 5.3e-57 193.7 0.4 1.0 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.21 PIK60458.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 Transposase DDE domain DUF309 PF03745.14 PIK60458.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF309) MIP PF00230.20 PIK60459.1 - 1.8e-61 207.8 11.9 2.2e-61 207.5 11.9 1.1 1 0 0 1 1 1 1 Major intrinsic protein EF-hand_1 PF00036.32 PIK60460.1 - 6.4e-22 75.4 14.9 0.00012 21.4 0.2 6.5 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 PIK60460.1 - 4.4e-21 73.0 19.0 0.00027 20.6 0.1 6.7 6 1 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 PIK60460.1 - 7.1e-21 74.4 12.4 3.5e-09 37.0 0.1 3.8 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 PIK60460.1 - 8.2e-11 40.9 11.3 0.00074 18.9 0.0 5.8 6 0 0 6 6 6 3 EF hand Caleosin PF05042.13 PIK60460.1 - 0.0003 20.8 3.4 0.17 11.8 0.0 3.6 4 1 1 5 5 5 2 Caleosin related protein EF-hand_8 PF13833.6 PIK60460.1 - 0.0012 18.7 10.6 0.058 13.3 0.1 4.9 4 3 1 5 5 5 2 EF-hand domain pair EF-hand_10 PF14788.6 PIK60460.1 - 0.0021 17.9 6.1 1.2 9.1 0.3 5.0 4 1 1 5 5 5 1 EF hand Myb_DNA-bind_5 PF13873.6 PIK60460.1 - 0.014 15.4 0.1 0.043 13.9 0.1 1.8 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain SPARC_Ca_bdg PF10591.9 PIK60460.1 - 3.3 8.1 6.4 25 5.2 0.1 4.1 2 2 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Cation_ATPase_C PF00689.21 PIK60461.1 - 2e-42 144.9 8.4 2e-42 144.9 8.4 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 PIK60461.1 - 3.5e-26 91.8 11.4 2.3e-24 85.9 0.0 3.6 4 0 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 PIK60461.1 - 1.4e-19 71.2 2.1 1.1e-18 68.2 2.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 PIK60461.1 - 3.3e-16 58.7 0.0 7.5e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 PIK60461.1 - 3.1e-12 46.4 0.0 8.4e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 PIK60461.1 - 0.0052 16.5 1.4 0.0052 16.5 1.4 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PhoR PF11808.8 PIK60461.1 - 0.06 13.8 0.1 3.5 8.1 0.0 2.8 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF1634 PF07843.11 PIK60461.1 - 0.074 13.1 6.2 0.032 14.3 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1634) zf-C2H2_4 PF13894.6 PIK60462.1 - 8.2e-15 54.2 32.6 0.00046 20.8 0.2 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK60462.1 - 1.3e-14 53.7 38.3 5.2e-05 23.5 0.5 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK60462.1 - 4e-09 36.5 29.7 0.0011 19.2 1.0 4.6 4 1 1 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 PIK60462.1 - 4.6e-07 30.0 37.1 0.032 14.7 7.3 5.9 5 1 0 5 5 5 4 Zinc-finger double domain zf-met PF12874.7 PIK60462.1 - 9.6e-06 25.8 23.9 0.063 13.7 1.0 4.3 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK60462.1 - 0.0031 17.8 26.6 0.76 10.1 4.0 4.0 1 1 3 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK60462.1 - 0.024 14.4 2.0 0.19 11.5 0.5 3.3 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-Di19 PF05605.12 PIK60462.1 - 0.03 14.6 3.4 0.03 14.6 3.4 3.2 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK60462.1 - 0.051 13.3 4.5 0.051 13.3 4.5 5.2 5 2 0 5 5 5 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 PIK60462.1 - 0.073 13.1 0.3 0.073 13.1 0.3 4.4 4 1 0 4 4 4 0 C2H2-type zinc finger PyrI_C PF02748.15 PIK60462.1 - 0.1 12.5 16.6 8.1 6.4 0.2 4.1 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Dak1_2 PF13684.6 PIK60462.1 - 0.16 11.0 1.0 0.18 10.8 0.2 1.4 2 0 0 2 2 2 0 Dihydroxyacetone kinase family COX5B PF01215.19 PIK60462.1 - 0.21 11.3 0.2 0.21 11.3 0.2 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Vb zf-FCS PF06467.14 PIK60462.1 - 0.39 10.7 17.6 3.5 7.6 0.3 4.1 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif Fer4_9 PF13187.6 PIK60462.1 - 0.59 10.3 9.6 3.9 7.7 3.3 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain zf-C2H2_9 PF16293.5 PIK60462.1 - 1.8 8.5 11.8 12 5.8 0.5 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) HNH_5 PF14279.6 PIK60462.1 - 2.4 8.1 16.6 4.6 7.2 5.2 3.1 2 1 0 2 2 2 0 HNH endonuclease TF_Zn_Ribbon PF08271.12 PIK60462.1 - 3.8 7.1 12.0 0.98 9.0 1.1 3.1 3 1 0 3 3 3 0 TFIIB zinc-binding zf-C2H2_8 PF15909.5 PIK60462.1 - 4.1 7.8 15.0 2.1 8.7 5.0 2.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 PIK60462.1 - 4.1 7.6 16.0 0.84 9.8 3.0 3.4 2 1 1 3 3 3 0 Zinc ribbon domain ADK_lid PF05191.14 PIK60462.1 - 9.1 6.4 13.0 3.3 7.8 3.4 3.2 3 1 0 3 3 3 0 Adenylate kinase, active site lid RWD PF05773.22 PIK60464.1 - 1.3e-18 67.4 0.5 2e-18 66.7 0.5 1.3 1 0 0 1 1 1 1 RWD domain YueH PF14166.6 PIK60464.1 - 0.056 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 YueH-like protein UEV PF05743.13 PIK60464.1 - 0.095 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 UEV domain RVT_1 PF00078.27 PIK60466.1 - 1.4e-43 149.0 1.3 1.4e-43 149.0 1.3 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) C2 PF00168.30 PIK60467.1 - 7.4e-19 68.0 0.0 1.2e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain PRKCSH_1 PF13015.6 PIK60468.1 - 6.6e-14 51.9 0.1 1.2e-13 51.1 0.1 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 PIK60468.1 - 6.9e-09 36.6 3.9 1.9e-08 35.2 3.8 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Nop14 PF04147.12 PIK60469.1 - 0.024 12.9 33.6 0.032 12.5 33.6 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 PIK60469.1 - 0.025 14.0 39.2 0.032 13.7 39.2 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 PIK60469.1 - 1.2 7.4 32.9 1.6 7.0 32.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Smg8_Smg9 PF10220.9 PIK60469.1 - 3.2 5.9 14.3 4.2 5.6 14.3 1.2 1 0 0 1 1 1 0 Smg8_Smg9 Astro_capsid_p PF12226.8 PIK60469.1 - 4.7 6.3 18.7 6.8 5.7 18.7 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein LAP1C PF05609.12 PIK60469.1 - 7 5.6 16.8 8.2 5.4 16.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) ER_lumen_recept PF00810.18 PIK60470.1 - 1.3e-54 185.0 10.1 1.9e-54 184.5 10.1 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor UQ_con PF00179.26 PIK60471.1 - 8.3e-41 138.9 0.0 1e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 PIK60471.1 - 1.7e-06 27.7 0.0 2.5e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B Patatin PF01734.22 PIK60472.1 - 9.9e-12 45.5 0.0 1.2e-11 45.2 0.0 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase GTP_EFTU PF00009.27 PIK60473.1 - 0.0022 17.5 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SUIM_assoc PF16619.5 PIK60473.1 - 0.013 15.6 6.7 0.013 15.6 6.7 2.7 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF1043 PF06295.12 PIK60473.1 - 0.055 13.5 2.7 0.11 12.5 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) HMG_box PF00505.19 PIK60474.1 - 4.4e-13 49.5 8.0 1.1e-12 48.2 8.0 1.7 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK60474.1 - 3.1e-05 24.5 6.4 6.8e-05 23.4 6.4 1.6 1 0 0 1 1 1 1 HMG-box domain Spc7 PF08317.11 PIK60474.1 - 0.071 12.0 0.1 0.071 12.0 0.1 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein Rho_Binding PF08912.11 PIK60474.1 - 0.37 11.6 6.5 15 6.5 2.5 2.5 2 0 0 2 2 2 0 Rho Binding Syntaxin_2 PF14523.6 PIK60474.1 - 1.4 9.4 4.5 1.3 9.4 0.5 2.2 2 0 0 2 2 2 0 Syntaxin-like protein BRE1 PF08647.11 PIK60474.1 - 1.6 8.9 7.5 1.6 8.8 0.5 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase HALZ PF02183.18 PIK60474.1 - 1.9 8.8 9.0 7 7.0 0.2 2.8 2 1 1 3 3 3 0 Homeobox associated leucine zipper HAGH_C PF16123.5 PIK60475.1 - 2.7e-27 95.1 0.0 4.8e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 PIK60475.1 - 1.2e-11 45.0 1.6 1.2e-10 41.7 1.6 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 PIK60475.1 - 0.0069 15.9 0.1 0.02 14.4 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Rap_GAP PF02145.15 PIK60476.1 - 3.7e-44 150.5 0.0 5.9e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 PIK60477.1 - 2.9e-108 362.1 3.1 2.9e-108 362.1 3.1 1.9 2 0 0 2 2 2 1 Tuberin DUF3384 PF11864.8 PIK60477.1 - 6.8e-89 299.0 4.0 2e-88 297.4 4.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) HEAT PF02985.22 PIK60477.1 - 0.012 15.8 0.0 0.78 10.2 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat RGS PF00615.19 PIK60478.1 - 1.7e-21 76.7 0.0 2.2e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 PIK60478.1 - 0.0061 16.3 0.0 0.0077 16.0 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Alginate_lyase2 PF08787.11 PIK60478.1 - 0.12 12.2 0.0 0.13 12.1 0.0 1.3 1 1 0 1 1 1 0 Alginate lyase Axin_b-cat_bind PF08833.10 PIK60479.1 - 5.9e-09 35.9 2.2 1.4e-08 34.6 2.2 1.7 1 0 0 1 1 1 1 Axin beta-catenin binding domain Caskin-tail PF16632.5 PIK60479.1 - 0.053 13.9 0.3 0.14 12.6 0.3 1.6 1 0 0 1 1 1 0 C-terminal region of Caskin TP2 PF01254.18 PIK60479.1 - 0.34 11.5 9.0 0.06 13.9 2.9 2.3 3 0 0 3 3 3 0 Nuclear transition protein 2 DIX PF00778.17 PIK60480.1 - 5.1e-10 39.0 0.2 8.6e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 DIX domain Macoilin PF09726.9 PIK60480.1 - 0.34 9.4 4.8 0.38 9.3 4.8 1.1 1 0 0 1 1 1 0 Macoilin family SAC3_GANP PF03399.16 PIK60481.1 - 1.6e-13 50.7 6.2 9.7e-12 44.9 6.2 2.6 1 1 1 2 2 2 1 SAC3/GANP family COX5A PF02284.16 PIK60481.1 - 0.069 13.2 0.1 0.31 11.0 0.1 2.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va U3_snoRNA_assoc PF08297.11 PIK60481.1 - 2.5 8.9 14.3 3.8 8.3 0.3 4.0 4 0 0 4 4 4 0 U3 snoRNA associated SMN PF06003.12 PIK60482.1 - 6 6.0 13.7 1.1 8.5 9.5 1.9 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) OATP PF03137.20 PIK60483.1 - 1e-23 83.5 0.0 1.3e-23 83.1 0.0 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family VWA_3 PF13768.6 PIK60484.1 - 4e-46 156.8 0.0 4.5e-18 65.7 0.0 3.9 4 0 0 4 4 4 3 von Willebrand factor type A domain VWA PF00092.28 PIK60484.1 - 2.2e-15 57.4 0.0 6e-07 29.9 0.0 3.9 3 1 1 4 4 4 3 von Willebrand factor type A domain VWA_2 PF13519.6 PIK60484.1 - 2.4e-11 44.2 0.0 0.0013 19.4 0.0 4.0 4 0 0 4 4 4 3 von Willebrand factor type A domain NinG PF05766.12 PIK60485.1 - 0.18 11.7 0.1 0.26 11.2 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein DUF3246 PF11596.8 PIK60486.1 - 0.58 9.5 3.7 8 5.8 1.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) BAH PF01426.18 PIK60489.1 - 5.8e-08 32.6 0.0 6.9e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 BAH domain DUF2090 PF09863.9 PIK60489.1 - 0.15 11.0 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) WD40 PF00400.32 PIK60491.1 - 7.2e-09 36.1 0.2 0.0012 19.7 0.1 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60491.1 - 6.3e-08 32.8 0.0 0.00048 20.4 0.0 2.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RtcR PF06956.11 PIK60492.1 - 0.35 10.3 4.3 0.44 10.0 0.2 2.5 2 1 1 3 3 3 0 Regulator of RNA terminal phosphate cyclase WD40 PF00400.32 PIK60493.1 - 1.8e-10 41.2 4.5 0.0085 16.9 0.0 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat HELP PF03451.14 PIK60493.1 - 0.0013 18.5 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 HELP motif Nucleoporin_N PF08801.11 PIK60493.1 - 0.0026 16.6 0.0 0.0057 15.4 0.0 1.6 1 1 0 1 1 1 1 Nup133 N terminal like ANAPC4_WD40 PF12894.7 PIK60493.1 - 0.0037 17.5 0.0 9.5 6.6 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Mito_carr PF00153.27 PIK60494.1 - 1.2e-14 54.0 0.1 4.3e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein WRW PF10206.9 PIK60495.1 - 9.5e-15 54.8 0.0 1.1e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f F1F0-ATPsyn_F PF10791.9 PIK60495.1 - 0.015 15.8 0.0 0.019 15.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi ENTH PF01417.20 PIK60496.1 - 4.7e-10 39.6 0.1 1.1e-09 38.4 0.0 1.7 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 PIK60496.1 - 0.041 12.9 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 ANTH domain Zip PF02535.22 PIK60497.1 - 6.4e-23 81.5 5.0 1.3e-22 80.5 5.0 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter FAM212 PF15342.6 PIK60498.1 - 0.51 10.2 5.6 2.6 7.9 0.0 3.2 2 1 1 3 3 3 0 FAM212 family 3Beta_HSD PF01073.19 PIK60499.1 - 8.1e-56 189.1 0.0 1e-55 188.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK60499.1 - 2e-22 79.8 0.0 3.8e-22 78.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 PIK60499.1 - 3.3e-10 39.5 0.0 4.6e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 PIK60499.1 - 1.7e-09 37.3 0.4 7.1e-09 35.2 0.4 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 PIK60499.1 - 2e-08 34.0 0.0 4.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 PIK60499.1 - 6.7e-08 32.0 0.0 1.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 PIK60499.1 - 1.6e-05 24.9 0.0 2.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 PIK60499.1 - 0.023 14.3 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 PIK60499.1 - 0.087 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Dynein_light PF01221.18 PIK60500.1 - 4.7e-16 58.9 1.1 5.8e-16 58.6 1.1 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF3109 PF11307.8 PIK60500.1 - 0.0026 17.6 0.1 0.0026 17.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3109) Cyclin_N PF00134.23 PIK60500.1 - 0.027 14.2 0.2 0.033 13.9 0.2 1.1 1 0 0 1 1 1 0 Cyclin, N-terminal domain RD3 PF14473.6 PIK60500.1 - 0.062 13.1 2.3 0.093 12.6 1.3 1.6 1 1 1 2 2 2 0 RD3 protein Endonuclease_5 PF04493.14 PIK60501.1 - 1.1e-30 106.8 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V HpaB PF03241.13 PIK60501.1 - 0.089 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal UvrC_HhH_N PF08459.11 PIK60501.1 - 0.11 12.4 0.0 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 UvrC Helix-hairpin-helix N-terminal 7tm_1 PF00001.21 PIK60502.1 - 7.7e-26 91.0 8.6 1e-25 90.6 8.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 PIK60502.1 - 0.0097 15.0 1.8 0.013 14.7 1.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2207 PF09972.9 PIK60502.1 - 0.027 13.2 0.3 0.096 11.4 0.1 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TctB PF07331.11 PIK60502.1 - 0.033 14.5 0.5 6.4 7.1 0.1 2.3 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family 7TM_GPCR_Srv PF10323.9 PIK60502.1 - 0.044 13.1 6.2 0.061 12.7 6.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF3810 PF12725.7 PIK60502.1 - 3.9 6.7 5.6 1.6 8.0 3.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) FMN_dh PF01070.18 PIK60504.1 - 7.2e-72 242.3 0.0 8.2e-72 242.1 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK60504.1 - 4.7e-10 39.0 0.3 4.1e-09 35.9 0.1 1.9 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK60504.1 - 0.00011 21.5 0.2 0.00021 20.6 0.2 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 PIK60504.1 - 0.00029 20.4 0.1 0.00039 19.9 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 PIK60504.1 - 0.01 15.1 0.1 2.2 7.5 0.0 2.7 3 0 0 3 3 3 0 Thiazole biosynthesis protein ThiG PA PF02225.22 PIK60504.1 - 0.18 11.8 1.5 2.9 8.0 0.0 2.7 2 1 1 3 3 3 0 PA domain DDA1 PF10172.9 PIK60505.1 - 0.026 14.8 0.7 0.062 13.6 0.7 1.6 1 0 0 1 1 1 0 Det1 complexing ubiquitin ligase FAA_hydrolase PF01557.18 PIK60506.1 - 7.2e-33 114.1 0.0 1.2e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 PIK60506.1 - 8.6e-22 77.4 0.0 2.4e-21 75.9 0.0 1.6 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal Laminin_EGF PF00053.24 PIK60507.1 - 2.2e-20 72.5 149.1 0.00068 19.7 10.5 9.8 2 2 7 9 9 9 7 Laminin EGF domain hEGF PF12661.7 PIK60507.1 - 3.2e-15 56.1 120.7 0.0026 18.3 3.9 12.5 13 0 0 13 13 13 8 Human growth factor-like EGF DSL PF01414.19 PIK60507.1 - 4.4e-13 49.3 166.1 0.00032 20.9 11.1 8.4 8 0 0 8 8 8 7 Delta serrate ligand EGF_2 PF07974.13 PIK60507.1 - 2.7e-08 34.1 186.0 0.0026 18.1 12.5 15.5 11 5 1 12 12 12 7 EGF-like domain EGF PF00008.27 PIK60507.1 - 1.5e-07 31.6 149.3 0.0017 18.6 9.9 12.3 13 1 0 13 13 13 8 EGF-like domain Laminin_EGF PF00053.24 PIK60508.1 - 6e-09 35.9 108.1 0.032 14.4 14.0 7.6 4 3 3 7 7 7 6 Laminin EGF domain hEGF PF12661.7 PIK60508.1 - 2.1e-08 34.5 79.0 5e-05 23.8 7.1 8.5 7 2 2 9 9 9 5 Human growth factor-like EGF DSL PF01414.19 PIK60508.1 - 0.0009 19.5 32.8 0.0029 17.8 11.5 6.4 6 0 0 6 6 6 4 Delta serrate ligand EGF_2 PF07974.13 PIK60508.1 - 0.0049 17.2 31.4 0.0064 16.8 13.6 10.9 11 2 1 12 12 12 4 EGF-like domain EGF PF00008.27 PIK60508.1 - 0.017 15.4 10.4 0.017 15.4 10.4 8.6 9 0 0 9 9 9 0 EGF-like domain NADase_NGA PF07461.11 PIK60508.1 - 0.3 9.9 0.0 0.43 9.4 0.0 1.1 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) Laminin_EGF PF00053.24 PIK60509.1 - 2.8e-07 30.6 75.9 0.0056 16.8 12.6 5.7 4 1 2 6 6 6 4 Laminin EGF domain hEGF PF12661.7 PIK60509.1 - 9.6e-05 22.9 72.3 0.0013 19.3 8.1 7.3 5 2 2 7 7 7 5 Human growth factor-like EGF EGF_2 PF07974.13 PIK60509.1 - 0.00026 21.3 93.2 0.0051 17.1 5.6 7.8 7 1 1 8 8 8 4 EGF-like domain DSL PF01414.19 PIK60509.1 - 0.011 16.0 9.9 0.011 16.0 9.9 5.2 5 0 0 5 5 5 0 Delta serrate ligand Laminin_EGF PF00053.24 PIK60510.1 - 4e-13 49.3 70.1 0.00016 21.8 9.4 4.3 2 1 2 4 4 4 3 Laminin EGF domain EGF_2 PF07974.13 PIK60510.1 - 2.8e-10 40.4 95.0 0.00057 20.2 10.5 7.6 7 1 0 7 7 7 7 EGF-like domain hEGF PF12661.7 PIK60510.1 - 1.9e-07 31.4 31.7 9.1e-05 22.9 1.1 7.6 8 2 0 8 8 8 3 Human growth factor-like EGF DSL PF01414.19 PIK60510.1 - 0.0035 17.6 14.9 0.0035 17.6 14.9 4.2 4 0 0 4 4 4 3 Delta serrate ligand EGF PF00008.27 PIK60510.1 - 0.012 15.8 83.0 0.085 13.2 11.7 7.2 7 0 0 7 7 7 0 EGF-like domain Peptidase_A17 PF05380.13 PIK60511.1 - 2.9e-48 163.9 0.0 2.9e-48 163.9 0.0 1.7 2 0 0 2 2 2 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 PIK60511.1 - 4.9e-06 26.6 0.6 2.6e-05 24.2 0.8 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK60511.1 - 2e-05 24.2 0.0 3.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Patched PF02460.18 PIK60512.1 - 9.1e-38 129.9 0.1 1.2e-37 129.5 0.1 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK60512.1 - 4.9e-07 29.7 1.5 4.9e-07 29.7 1.5 2.1 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation FYVE PF01363.21 PIK60513.1 - 1.3e-16 60.5 20.5 3.3e-16 59.2 20.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger GOLD_2 PF13897.6 PIK60513.1 - 0.0024 18.4 0.0 0.0024 18.4 0.0 4.8 2 1 3 5 5 5 2 Golgi-dynamics membrane-trafficking IBR PF01485.21 PIK60513.1 - 5.6 7.3 17.6 0.8 10.0 12.5 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Exonuc_VII_L PF02601.15 PIK60513.1 - 9.9 5.6 10.1 19 4.7 10.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit 2-Hacid_dh_C PF02826.19 PIK60514.1 - 9.2e-43 145.7 0.0 1.4e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 PIK60514.1 - 1.9e-05 24.2 0.0 5.2e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 ThiF family Oxidored_nitro PF00148.19 PIK60514.1 - 0.00012 20.9 0.0 0.00016 20.5 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase F420_oxidored PF03807.17 PIK60514.1 - 0.00052 20.5 0.0 0.0013 19.2 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 PIK60514.1 - 0.00074 19.6 0.0 0.0022 18.1 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 PIK60514.1 - 0.0027 18.2 0.0 0.0062 17.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 PIK60514.1 - 0.0037 17.4 0.0 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 PIK60514.1 - 0.0046 16.2 0.0 0.0068 15.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh PF00389.30 PIK60514.1 - 0.0063 16.2 0.0 0.013 15.2 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain HTH_56 PF18662.1 PIK60514.1 - 0.11 12.5 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 Cch helix turn helix domain Glyco_transf_10 PF00852.19 PIK60515.1 - 3.1e-54 183.4 0.1 3.8e-54 183.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term PIP5K PF01504.18 PIK60516.1 - 1e-30 106.9 0.2 7.3e-20 71.3 0.2 3.0 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase PDCD2_C PF04194.13 PIK60517.1 - 1.2e-25 90.6 0.0 1.2e-25 90.6 0.0 3.1 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain YdjO PF14169.6 PIK60517.1 - 0.041 13.6 2.0 4.2 7.2 0.1 3.1 3 0 0 3 3 3 0 Cold-inducible protein YdjO Prok-RING_1 PF14446.6 PIK60517.1 - 1.7 8.6 8.0 0.23 11.4 2.8 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 TNFR_c6 PF00020.18 PIK60519.1 - 2.2e-07 31.2 43.0 4.6e-05 23.7 10.9 4.6 5 0 0 5 5 5 3 TNFR/NGFR cysteine-rich region DED PF01335.21 PIK60519.1 - 0.0018 18.5 0.0 0.0042 17.4 0.0 1.5 1 0 0 1 1 1 1 Death effector domain Pkinase_Tyr PF07714.17 PIK60520.1 - 1.3e-78 263.8 0.0 1.9e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60520.1 - 5e-33 114.6 0.0 7.3e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK60520.1 - 1.9e-16 59.9 0.1 3.7e-16 59.0 0.1 1.5 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 PIK60520.1 - 1.5e-12 48.0 0.1 8e-12 45.6 0.0 2.3 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 PIK60520.1 - 1.9e-11 43.4 0.4 5e-11 42.0 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK60520.1 - 6e-10 38.8 0.6 2.1e-09 37.1 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain BTK PF00779.19 PIK60520.1 - 1.5e-08 34.3 6.1 3.9e-08 33.0 6.1 1.8 1 0 0 1 1 1 1 BTK motif SH3_2 PF07653.17 PIK60520.1 - 3.7e-07 29.7 0.0 1e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 PIK60520.1 - 0.0023 18.0 0.0 0.0058 16.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 PIK60520.1 - 0.0031 17.8 1.2 0.0065 16.7 0.3 2.0 2 0 0 2 2 2 1 Bacterial SH3 domain Kinase-like PF14531.6 PIK60520.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 PIK60520.1 - 0.056 13.3 0.1 0.093 12.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK60520.1 - 0.082 11.8 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Myotub-related PF06602.14 PIK60521.1 - 3.8e-147 489.8 0.2 5.5e-147 489.3 0.2 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 PIK60521.1 - 2.5e-17 62.8 0.0 8.3e-17 61.1 0.0 1.8 2 0 0 2 2 2 1 GRAM domain 3-PAP PF12578.8 PIK60521.1 - 6.3e-05 22.7 0.7 0.0014 18.4 0.4 2.6 2 0 0 2 2 2 1 Myotubularin-associated protein Y_phosphatase PF00102.27 PIK60521.1 - 0.00052 19.7 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 PIK60521.1 - 0.0024 17.9 0.0 0.0057 16.6 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 PIK60521.1 - 0.041 13.7 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF2709 PF10915.8 PIK60521.1 - 0.11 11.7 0.1 0.34 10.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2709) Period_C PF12114.8 PIK60521.1 - 0.56 9.8 4.4 1.3 8.6 4.4 1.5 1 0 0 1 1 1 0 Period protein 2/3C-terminal region EamA PF00892.20 PIK60522.1 - 1.2e-14 54.6 25.3 1.2e-11 44.9 3.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family Claudin_3 PF06653.11 PIK60522.1 - 0.98 9.3 13.7 0.14 12.0 9.3 1.9 2 1 0 2 2 2 0 Tight junction protein, Claudin-like Amidohydro_1 PF01979.20 PIK60523.1 - 8.5e-09 35.2 0.0 8.6e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK60523.1 - 1.3e-07 31.5 0.0 1.5e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 PIK60524.1 - 1.2e-05 24.8 0.1 1.6e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family rve PF00665.26 PIK60525.1 - 2.8e-25 88.8 0.0 7.6e-25 87.4 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60525.1 - 1.4e-19 69.9 5.2 1.7e-19 69.7 2.7 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK60525.1 - 0.00026 20.7 0.0 0.00073 19.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK60525.1 - 0.37 11.0 2.4 0.83 9.9 2.4 1.6 1 0 0 1 1 1 0 H2C2 zinc finger RT_RNaseH_2 PF17919.1 PIK60526.1 - 1.1e-35 121.6 0.0 1.6e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK60526.1 - 1.7e-35 121.5 0.1 2.3e-35 121.0 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Spuma_A9PTase PF03539.14 PIK60527.1 - 3.7e-05 23.9 0.0 0.11 12.7 0.0 2.2 1 1 1 2 2 2 2 Spumavirus aspartic protease (A9) Gemin6 PF06372.12 PIK60528.1 - 2.1e-30 105.4 0.0 2.6e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Gemin6 protein AD PF09793.9 PIK60528.1 - 0.007 16.5 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain MethyltransfD12 PF02086.15 PIK60528.1 - 0.027 14.2 0.0 0.036 13.7 0.0 1.2 1 1 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Sprouty PF05210.13 PIK60529.1 - 1.8e-26 92.5 31.2 2.9e-26 91.8 31.2 1.3 1 0 0 1 1 1 1 Sprouty protein (Spry) DUF2370 PF10176.9 PIK60530.1 - 4.5e-08 33.0 0.8 4.5e-08 33.0 0.8 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF2370) PHO4 PF01384.20 PIK60530.1 - 0.092 11.8 0.6 0.12 11.4 0.6 1.1 1 0 0 1 1 1 0 Phosphate transporter family CH_2 PF06294.11 PIK60531.1 - 2.7e-32 110.8 0.0 5.1e-32 109.8 0.0 1.5 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 PIK60531.1 - 9.9e-15 54.1 0.0 2.1e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Nup96 PF12110.8 PIK60532.1 - 0.033 13.3 0.1 0.067 12.3 0.1 1.5 1 0 0 1 1 1 0 Nuclear protein 96 Clathrin PF00637.20 PIK60532.1 - 0.044 13.6 0.0 0.18 11.6 0.0 2.1 2 1 0 2 2 2 0 Region in Clathrin and VPS GCH_III PF05165.12 PIK60532.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase III Exonuc_VII_S PF02609.16 PIK60532.1 - 0.17 12.0 0.1 0.72 10.0 0.1 2.1 1 0 0 1 1 1 0 Exonuclease VII small subunit WD40 PF00400.32 PIK60533.1 - 3.3e-09 37.2 1.3 0.0017 19.1 0.0 4.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60533.1 - 0.00033 20.9 0.0 0.64 10.4 0.0 2.5 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 PIK60533.1 - 0.056 12.1 0.1 0.13 10.9 0.1 1.5 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SERTA PF06031.13 PIK60533.1 - 0.22 11.2 0.0 0.41 10.4 0.0 1.4 1 0 0 1 1 1 0 SERTA motif Methyltransf_32 PF13679.6 PIK60535.1 - 0.00041 20.4 0.1 0.00066 19.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 PIK60535.1 - 0.14 11.4 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.6 PIK60536.1 - 8.3e-06 25.9 0.2 1.1e-05 25.5 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 PIK60536.1 - 0.02 14.4 0.0 0.02 14.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 Methyltransf_11 PF08241.12 PIK60538.1 - 1.5e-12 48.0 0.0 2.6e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK60538.1 - 1e-08 35.8 0.0 1.7e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK60538.1 - 0.00023 21.0 0.0 0.00032 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK60538.1 - 0.00024 21.0 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK60538.1 - 0.00081 20.1 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 PIK60538.1 - 0.024 14.5 0.1 0.037 13.9 0.1 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.20 PIK60538.1 - 0.16 11.2 0.0 0.24 10.7 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Mito_carr PF00153.27 PIK60539.1 - 2e-36 123.8 3.2 1.5e-17 63.2 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein RVT_1 PF00078.27 PIK60540.1 - 1.9e-23 83.1 0.0 2.4e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ifi-6-16 PF06140.13 PIK60541.1 - 3.8e-17 62.0 18.2 5.4e-17 61.5 18.2 1.2 1 0 0 1 1 1 1 Interferon-induced 6-16 family MitoNEET_N PF10660.9 PIK60541.1 - 0.094 12.7 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Flavi_NS2B PF01002.19 PIK60541.1 - 0.13 12.2 0.8 0.16 11.8 0.8 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2B DUF4781 PF16013.5 PIK60541.1 - 0.52 9.1 4.3 0.68 8.7 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF726 PF05277.12 PIK60541.1 - 2.4 7.0 8.5 3 6.7 8.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF5353 PF17304.2 PIK60541.1 - 4.3 7.1 9.0 0.87 9.4 3.1 2.5 1 1 2 3 3 3 0 Family of unknown function (DUF5353) SNF PF00209.18 PIK60543.1 - 1e-88 298.4 19.2 1.2e-88 298.2 19.2 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family An_peroxidase PF03098.15 PIK60544.1 - 2.2e-117 392.8 0.0 2.5e-117 392.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase DUF5073 PF16817.5 PIK60544.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5073) An_peroxidase PF03098.15 PIK60545.1 - 1.9e-85 287.5 0.0 1.2e-56 192.4 0.0 2.1 1 1 1 2 2 2 2 Animal haem peroxidase ZU5 PF00791.20 PIK60546.1 - 2e-13 50.5 0.0 6.8e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain DED PF01335.21 PIK60546.1 - 0.00035 20.8 1.9 0.21 11.9 0.2 2.6 2 0 0 2 2 2 2 Death effector domain GAS PF13851.6 PIK60547.1 - 6.9e-07 28.8 67.8 0.00022 20.7 31.6 2.4 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ERM PF00769.19 PIK60547.1 - 0.0039 17.1 28.2 0.0039 17.1 28.2 2.5 1 1 1 2 2 2 1 Ezrin/radixin/moesin family PilA4 PF18682.1 PIK60547.1 - 0.034 14.5 8.7 8.6 6.8 0.2 4.1 1 1 3 4 4 4 0 Pilin A4 DUF4284 PF14112.6 PIK60547.1 - 0.11 13.5 1.4 38 5.2 0.0 3.5 1 1 2 3 3 3 0 Immunity protein 22 APG6_N PF17675.1 PIK60547.1 - 0.18 12.4 78.8 43 4.6 25.2 3.9 1 1 1 2 2 2 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 PIK60547.1 - 0.18 12.4 70.3 0.24 12.0 22.1 4.0 3 1 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 T2SSN PF01203.19 PIK60547.1 - 0.78 9.9 9.8 7.5 6.7 1.9 3.2 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein N FPP PF05911.11 PIK60547.1 - 1.2 7.2 52.9 0.0051 15.1 24.5 2.9 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Fez1 PF06818.15 PIK60547.1 - 1.5 9.2 58.8 0.25 11.8 28.4 2.4 1 1 1 2 2 2 0 Fez1 KASH_CCD PF14662.6 PIK60547.1 - 2.9 7.7 67.7 0.59 9.9 20.5 3.8 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF4472 PF14739.6 PIK60547.1 - 4 8.2 55.1 3.8 8.3 17.9 4.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4472) DUF2009 PF09418.10 PIK60547.1 - 4.7 6.2 25.9 1.2 8.1 11.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2009) An_peroxidase PF03098.15 PIK60548.1 - 5.6e-28 97.8 0.0 7.2e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 PIK60549.1 - 7e-20 71.1 0.0 9.7e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 PIK60550.1 - 1.7e-40 139.1 0.2 2e-40 138.9 0.2 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Cgr1 PF03879.14 PIK60551.1 - 2e-12 47.5 23.6 2.7e-12 47.0 23.6 1.1 1 0 0 1 1 1 1 Cgr1 family HECT PF00632.25 PIK60552.1 - 2.1e-83 280.3 0.1 3.5e-83 279.6 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ocular_alb PF02101.15 PIK60553.1 - 3.5e-09 36.1 0.0 3.7e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein Acyl_transf_3 PF01757.22 PIK60553.1 - 0.00063 18.9 0.2 0.00071 18.7 0.2 1.0 1 0 0 1 1 1 1 Acyltransferase family zf-Tim10_DDP PF02953.15 PIK60554.1 - 1.3e-21 76.0 1.1 1.8e-21 75.5 1.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger HTH_Tnp_Tc5 PF03221.16 PIK60554.1 - 0.18 11.8 0.0 0.28 11.2 0.0 1.2 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain zf-FCS PF06467.14 PIK60555.1 - 0.033 14.1 4.0 32 4.6 0.1 3.7 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DUF3713 PF12506.8 PIK60555.1 - 0.084 13.2 0.5 0.21 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) XAF1_C PF18608.1 PIK60555.1 - 0.24 11.0 7.9 0.55 9.8 0.3 2.8 3 0 0 3 3 3 0 XIAP-associated factor 1 C-terminal domain zf_UBZ PF18439.1 PIK60555.1 - 0.3 10.7 11.9 0.43 10.2 0.6 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger AP_endonuc_2 PF01261.24 PIK60556.1 - 0.0056 16.1 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Ntox35 PF15534.6 PIK60556.1 - 0.25 11.8 1.6 6.3 7.3 0.1 2.8 1 1 1 2 2 2 0 Bacterial toxin 35 ELO PF01151.18 PIK60557.1 - 7.3e-64 215.7 23.5 8.7e-64 215.4 23.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Presenilin PF01080.17 PIK60558.1 - 8.4 5.0 6.7 9 4.9 6.7 1.0 1 0 0 1 1 1 0 Presenilin SMAP PF15477.6 PIK60559.1 - 4.8e-13 49.9 1.7 4.8e-13 49.9 1.7 2.5 2 1 0 2 2 2 1 Small acidic protein family FGGY_N PF00370.21 PIK60560.1 - 6.4e-05 22.6 0.0 9.8e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain EST1_DNA_bind PF10373.9 PIK60561.1 - 7.7e-50 170.0 0.1 3e-34 118.8 0.0 2.5 2 1 1 3 3 3 2 Est1 DNA/RNA binding domain EST1 PF10374.9 PIK60561.1 - 1.1e-13 51.9 1.0 4e-13 50.2 1.0 2.0 1 0 0 1 1 1 1 Telomerase activating protein Est1 PIN_4 PF13638.6 PIK60561.1 - 7.7e-08 32.7 0.5 3.4e-07 30.6 0.5 2.2 1 1 0 1 1 1 1 PIN domain Spt4 PF06093.13 PIK60562.1 - 1.3e-32 111.7 2.8 1.6e-32 111.4 2.8 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger CAP_GLY PF01302.25 PIK60564.1 - 1.2e-37 127.7 3.2 5.7e-23 80.7 0.1 2.4 2 0 0 2 2 2 2 CAP-Gly domain Spc7 PF08317.11 PIK60564.1 - 0.00043 19.3 34.1 0.00043 19.3 34.1 8.5 2 2 6 8 8 8 3 Spc7 kinetochore protein ATG16 PF08614.11 PIK60564.1 - 0.0015 18.8 37.6 0.0015 18.8 37.6 10.3 2 1 8 11 11 11 4 Autophagy protein 16 (ATG16) Fez1 PF06818.15 PIK60564.1 - 0.0025 18.3 35.8 0.0025 18.3 35.8 9.3 1 1 8 9 9 9 4 Fez1 DUF5527 PF17665.1 PIK60564.1 - 6.4 6.3 7.9 1 8.9 0.1 3.4 3 1 1 4 4 4 0 Family of unknown function (DUF5527) CCDC74_C PF14917.6 PIK60565.1 - 5.4e-21 75.4 17.0 3.3e-19 69.6 3.8 3.4 2 1 0 2 2 2 1 Coiled coil protein 74, C terminal CCDC92 PF14916.6 PIK60565.1 - 7.1e-18 64.1 4.8 7.1e-18 64.1 4.8 2.7 3 0 0 3 3 3 1 Coiled-coil domain of unknown function V_ATPase_I PF01496.19 PIK60565.1 - 0.048 11.6 2.0 0.077 10.9 2.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TSC22 PF01166.18 PIK60565.1 - 0.07 13.5 6.9 1 9.7 1.1 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family ECH_2 PF16113.5 PIK60565.1 - 0.071 12.6 4.0 0.15 11.5 4.0 1.6 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF3972 PF13118.6 PIK60565.1 - 0.26 11.7 7.8 0.096 13.1 2.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3972) LCD1 PF09798.9 PIK60565.1 - 0.34 9.4 17.2 0.15 10.6 11.7 1.7 1 1 1 2 2 2 0 DNA damage checkpoint protein ZapB PF06005.12 PIK60565.1 - 1.1 9.8 10.6 2.1 8.8 2.9 3.1 3 0 0 3 3 3 0 Cell division protein ZapB MNR PF15718.5 PIK60566.1 - 3.5e-59 200.9 54.2 1.2e-56 192.5 50.3 3.7 2 1 0 2 2 2 2 Protein moonraker Imm71 PF15602.6 PIK60566.1 - 0.02 15.0 0.4 0.074 13.1 0.4 2.0 1 0 0 1 1 1 0 Immunity protein 71 ACOX PF01756.19 PIK60566.1 - 0.15 11.7 0.6 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Acyl-CoA oxidase MRP-63 PF14978.6 PIK60567.1 - 9.6e-23 80.6 5.0 1e-22 80.5 5.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome protein 63 Pkinase PF00069.25 PIK60568.1 - 6.2e-23 81.5 0.0 1.1e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60568.1 - 1e-07 31.5 0.0 1.4e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4361 PF14274.6 PIK60568.1 - 0.13 12.5 0.0 7 6.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4361) Toxin_30 PF08117.11 PIK60568.1 - 0.55 10.5 2.2 1.9 8.8 2.2 2.0 1 1 0 1 1 1 0 Ptu family Filamin PF00630.19 PIK60569.1 - 0.017 15.9 0.0 0.11 13.3 0.0 2.3 1 1 0 1 1 1 0 Filamin/ABP280 repeat RVT_1 PF00078.27 PIK60570.1 - 8.3e-16 58.2 0.0 1.1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.12 PIK60570.1 - 0.11 12.4 0.3 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 ZU5 PF00791.20 PIK60574.1 - 7e-14 52.0 0.0 1.6e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Mis12 PF05859.12 PIK60575.1 - 0.086 12.9 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Mis12 protein PhoU PF01895.19 PIK60575.1 - 0.12 12.8 0.0 0.46 11.0 0.0 1.9 2 1 0 2 2 2 0 PhoU domain Mucin15 PF15672.5 PIK60576.1 - 0.034 13.6 4.0 0.042 13.3 4.0 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 YTV PF07639.11 PIK60576.1 - 2 8.6 9.3 11 6.1 0.1 3.9 3 2 0 3 3 3 0 YTV SMP PF04927.12 PIK60577.1 - 0.032 14.7 1.8 3.5 8.2 0.0 3.4 3 2 1 4 4 4 0 Seed maturation protein Pro_dh-DNA_bdg PF14850.6 PIK60577.1 - 0.58 10.7 5.5 11 6.6 1.0 3.0 2 2 1 3 3 3 0 DNA-binding domain of Proline dehydrogenase ZU5 PF00791.20 PIK60578.1 - 1.4e-08 34.9 0.3 5.4e-08 33.1 0.0 2.1 3 0 0 3 3 3 1 ZU5 domain ZU5 PF00791.20 PIK60580.1 - 6.3e-14 52.1 0.0 1.4e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK60581.1 - 1.6e-13 50.7 0.8 2.9e-13 49.8 0.6 1.6 2 0 0 2 2 2 1 Death domain HTH_psq PF05225.16 PIK60582.1 - 2e-07 30.6 0.0 4.2e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 PIK60582.1 - 4.8e-06 26.5 0.0 7.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 PIK60582.1 - 0.017 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Bombinin PF05298.11 PIK60582.1 - 0.044 13.5 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Bombinin zf-CCHC PF00098.23 PIK60583.1 - 0.0014 18.6 2.2 0.0014 18.6 2.2 3.0 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK60583.1 - 0.14 11.9 15.3 0.81 9.5 2.6 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF3866 PF12982.7 PIK60583.1 - 0.42 9.7 1.9 0.49 9.5 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3866) Lebercilin PF15619.6 PIK60584.1 - 0.00025 20.8 6.2 0.00035 20.3 6.2 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease T3SSipB PF16535.5 PIK60584.1 - 0.0031 18.0 2.2 0.0031 18.0 2.2 2.2 2 0 0 2 2 2 1 Type III cell invasion protein SipB GAS PF13851.6 PIK60584.1 - 0.04 13.3 4.8 0.061 12.7 4.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.9 PIK60584.1 - 0.041 14.1 4.2 0.076 13.2 4.2 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 KELK PF15796.5 PIK60584.1 - 0.085 13.3 5.3 0.2 12.1 5.3 1.6 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Vfa1 PF08432.10 PIK60584.1 - 2.5 8.4 11.1 2.1 8.6 2.8 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 ATP-synt_B PF00430.18 PIK60584.1 - 4.3 7.4 6.1 1 9.4 1.2 2.1 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) ZU5 PF00791.20 PIK60585.1 - 9.7e-09 35.5 0.1 2.5e-08 34.2 0.1 1.7 1 0 0 1 1 1 1 ZU5 domain ERM PF00769.19 PIK60586.1 - 3e-07 30.5 24.6 6.8e-07 29.3 24.6 1.7 1 0 0 1 1 1 1 Ezrin/radixin/moesin family HIP1_clath_bdg PF16515.5 PIK60586.1 - 0.025 15.2 18.3 0.025 15.2 18.3 3.1 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 KASH_CCD PF14662.6 PIK60586.1 - 0.043 13.7 33.3 0.12 12.2 33.3 1.8 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 PIK60586.1 - 0.19 11.1 40.0 0.12 11.7 24.7 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 PIK60586.1 - 0.36 8.3 28.3 0.5 7.8 28.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_11 PF13086.6 PIK60586.1 - 1.7 8.3 23.2 20 4.9 23.2 2.3 1 1 0 1 1 1 0 AAA domain Atg14 PF10186.9 PIK60586.1 - 3.3 6.7 26.4 6.2 5.8 26.4 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2514 PF10721.9 PIK60586.1 - 3.5 7.7 8.2 6.4 6.8 8.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) DUF1664 PF07889.12 PIK60586.1 - 6.9 6.7 17.7 1.2 9.2 8.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CLCA PF08434.11 PIK60588.1 - 7e-46 156.7 1.7 2.4e-33 115.6 0.0 2.4 1 1 1 2 2 2 2 Calcium-activated chloride channel N terminal VWA PF00092.28 PIK60588.1 - 4.6e-11 43.3 0.3 8.4e-11 42.4 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 PIK60588.1 - 3e-08 33.7 0.0 5.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 PIK60588.1 - 2.5e-07 31.3 0.1 5.9e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Lectin_C PF00059.21 PIK60589.1 - 4.9e-09 36.9 4.6 4.3e-08 33.9 1.7 2.6 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.12 PIK60589.1 - 0.7 9.5 6.8 7.5 6.1 1.4 2.8 2 2 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Sulfotransfer_1 PF00685.27 PIK60590.1 - 3.5e-08 33.3 0.0 9.3e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK60590.1 - 7e-08 33.1 0.0 3.4e-06 27.6 0.0 2.8 1 1 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK60590.1 - 0.0072 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Zona_pellucida PF00100.23 PIK60591.1 - 0.039 13.8 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Zona pellucida-like domain DOG1 PF14144.6 PIK60591.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Seed dormancy control Neur_chan_LBD PF02931.23 PIK60593.1 - 2.3e-33 115.5 0.1 3.7e-33 114.8 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 PIK60594.1 - 2.8e-42 144.6 2.5 3.8e-42 144.2 2.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK60594.1 - 9.2e-21 75.0 7.2 1.5e-19 71.0 6.5 2.1 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Frag1 PF10277.9 PIK60594.1 - 0.21 11.1 6.8 0.34 10.4 4.4 2.0 2 0 0 2 2 2 0 Frag1/DRAM/Sfk1 family DUF2207 PF09972.9 PIK60594.1 - 1.3 7.7 4.2 10 4.7 4.3 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Fig1 PF12351.8 PIK60594.1 - 2.4 8.1 7.2 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 DUF2842 PF11003.8 PIK60594.1 - 3.6 7.9 7.3 1.8 8.9 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) Y_phosphatase PF00102.27 PIK60595.1 - 1.3e-22 80.5 0.4 1.5e-22 80.3 0.4 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 PIK60595.1 - 0.034 14.0 0.1 0.067 13.0 0.0 1.6 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 PIK60596.1 - 1.5e-06 28.4 0.7 2.7e-06 27.6 0.7 1.4 1 0 0 1 1 1 1 Fibronectin type III domain DUF1065 PF06358.11 PIK60596.1 - 0.084 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1065) rve PF00665.26 PIK60597.1 - 1.2e-05 25.4 0.0 5.4e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK60597.1 - 0.00019 21.1 0.0 0.00042 20.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain IF2_N PF04760.15 PIK60597.1 - 0.046 13.5 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region RVT_2 PF07727.14 PIK60598.1 - 1.2e-76 257.6 2.4 1.5e-76 257.3 2.4 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF432 PF04254.13 PIK60598.1 - 0.0093 16.1 0.2 0.017 15.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF432) MTS PF05175.14 PIK60599.1 - 0.076 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PRRSV_Env PF02340.15 PIK60599.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 PRRSV putative envelope protein Y_phosphatase PF00102.27 PIK60600.1 - 1.4e-100 335.8 0.1 1.4e-50 172.1 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 PIK60600.1 - 1.9e-07 30.9 0.2 0.00018 21.3 0.1 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 PIK60600.1 - 0.0044 17.1 0.2 0.094 12.8 0.0 2.8 3 1 0 3 3 3 1 Inositol hexakisphosphate Phage_glycop_gL PF11108.8 PIK60600.1 - 0.021 14.9 0.0 10 6.2 0.0 2.9 3 0 0 3 3 3 0 Viral glycoprotein L CBS PF00571.28 PIK60600.1 - 0.056 13.9 0.4 1.8 9.1 0.2 2.5 2 0 0 2 2 2 0 CBS domain XPA_C PF05181.12 PIK60600.1 - 0.16 12.0 0.6 0.74 9.8 0.0 2.4 2 0 0 2 2 2 0 XPA protein C-terminus fn3 PF00041.21 PIK60601.1 - 0.0024 18.2 2.2 0.0063 16.8 0.9 2.2 2 0 0 2 2 2 1 Fibronectin type III domain ICAM_N PF03921.14 PIK60601.1 - 0.1 12.3 0.1 0.89 9.3 0.1 2.3 1 1 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain TMEM40 PF15817.5 PIK60601.1 - 0.19 11.5 0.1 0.8 9.5 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 40 family RVT_1 PF00078.27 PIK60602.1 - 1.1e-06 28.4 0.1 2.5e-06 27.2 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.6 PIK60602.1 - 0.019 14.6 3.6 0.037 13.8 3.6 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger ATG16 PF08614.11 PIK60603.1 - 0.019 15.2 29.7 0.019 15.2 29.7 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SCP-1 PF05483.12 PIK60603.1 - 0.071 11.1 61.2 0.061 11.3 60.1 1.3 1 1 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) Peptidase_S46 PF10459.9 PIK60603.1 - 0.45 9.1 32.5 0.55 8.8 32.5 1.1 1 0 0 1 1 1 0 Peptidase S46 TPR_MLP1_2 PF07926.12 PIK60603.1 - 4.4 7.4 68.4 0.077 13.1 32.0 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 PIK60603.1 - 6.9 5.9 52.1 9.3 5.5 25.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Trans_reg_C PF00486.28 PIK60605.1 - 0.025 14.7 0.5 5.2 7.2 0.3 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal TssO PF17561.2 PIK60605.1 - 0.052 13.6 0.1 0.075 13.1 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF4167 PF13763.6 PIK60605.1 - 0.093 12.9 0.9 0.16 12.1 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) DUF16 PF01519.16 PIK60605.1 - 0.16 12.4 1.5 1.6 9.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Y_phosphatase PF00102.27 PIK60606.1 - 2.7e-08 33.7 0.1 3e-08 33.5 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF1071 PF06378.11 PIK60606.1 - 0.058 13.0 0.3 0.071 12.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Mfa_like_1 PF13149.6 PIK60607.1 - 0.029 14.4 0.0 0.031 14.3 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin-like DarA_N PF18788.1 PIK60607.1 - 0.12 12.5 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Defence against restriction A N-terminal Ig_3 PF13927.6 PIK60608.1 - 0.0022 18.6 0.7 0.045 14.3 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60608.1 - 0.01 16.1 0.3 0.066 13.5 0.0 2.2 2 1 0 2 2 2 0 Immunoglobulin domain Ig_4 PF16680.5 PIK60608.1 - 0.032 14.5 0.0 0.77 10.1 0.0 2.6 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 PIK60608.1 - 0.052 14.0 0.0 0.37 11.2 0.0 2.2 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK60608.1 - 0.18 11.9 0.0 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain 7tm_1 PF00001.21 PIK60609.1 - 8.3e-11 41.7 17.4 1.3e-10 41.1 17.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK60609.1 - 7.2e-06 25.6 18.5 9e-05 22.0 18.5 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv ZIP4_domain PF18292.1 PIK60610.1 - 6.9e-15 55.4 0.4 9.7e-15 54.9 0.4 1.2 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain DUF2796 PF10986.8 PIK60610.1 - 0.045 13.7 14.0 0.091 12.7 14.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Zip PF02535.22 PIK60610.1 - 2.6 7.2 8.1 3.9 6.6 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Zip PF02535.22 PIK60611.1 - 3.1e-53 181.1 15.6 3.1e-52 177.9 15.6 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter RVT_1 PF00078.27 PIK60612.1 - 2.2e-20 73.2 0.0 3.3e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF PF00008.27 PIK60613.1 - 0.004 17.4 5.6 0.004 17.4 5.6 5.0 5 1 0 5 5 5 2 EGF-like domain EGF_2 PF07974.13 PIK60613.1 - 0.37 11.2 38.4 0.068 13.5 9.5 4.6 3 2 0 3 3 3 0 EGF-like domain UPF0160 PF03690.13 PIK60614.1 - 4e-85 286.2 0.0 4.5e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) UPF0160 PF03690.13 PIK60615.1 - 1.8e-38 133.0 0.0 2e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) GTP_CH_N PF12471.8 PIK60615.1 - 0.046 13.5 0.0 0.053 13.3 0.0 1.1 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal ApoL PF05461.11 PIK60616.1 - 1.3e-08 34.6 11.7 1.1e-05 24.9 2.6 2.5 2 1 0 2 2 2 2 Apolipoprotein L ubiquitin PF00240.23 PIK60617.1 - 4.2e-13 48.8 0.0 6.5e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 PIK60617.1 - 0.0061 17.0 0.0 0.019 15.4 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain PRP21_like_P PF12230.8 PIK60618.1 - 3.3e-22 79.4 1.8 3.3e-22 79.4 1.8 1.6 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 PIK60619.1 - 1.1e-33 115.0 5.9 7.6e-20 70.7 1.0 2.5 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 PIK60619.1 - 2.3e-22 79.9 3.2 3.8e-22 79.2 3.2 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein VHL PF01847.16 PIK60620.1 - 2.4e-19 69.0 0.1 3.4e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 VHL beta domain ELO PF01151.18 PIK60621.1 - 4.3e-46 157.5 15.8 6e-46 157.0 15.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family DUF4770 PF15994.5 PIK60623.1 - 0.00063 20.0 4.1 0.0018 18.6 4.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4770) zf-CCCH_4 PF18044.1 PIK60623.1 - 0.011 15.5 11.1 0.042 13.6 3.6 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger Torus PF16131.5 PIK60623.1 - 0.018 15.7 11.3 0.12 13.1 3.9 2.5 1 1 1 2 2 2 0 Torus domain Myticin-prepro PF10690.9 PIK60623.1 - 0.026 14.7 0.5 0.026 14.7 0.5 2.1 3 0 0 3 3 3 0 Myticin pre-proprotein from the mussel zf-CCCH PF00642.24 PIK60623.1 - 0.046 13.6 10.7 1.2 9.1 0.4 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 PIK60623.1 - 0.13 12.8 10.7 0.26 11.8 1.9 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 PIK60623.1 - 0.19 11.8 14.6 0.19 11.9 2.1 3.3 2 1 0 2 2 2 0 Zinc finger domain Auxin_canalis PF05703.11 PIK60624.1 - 0.014 15.4 3.9 0.017 15.1 3.9 1.1 1 0 0 1 1 1 0 Auxin canalisation Nop53 PF07767.11 PIK60624.1 - 0.019 14.4 19.5 0.023 14.1 19.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3292 PF11696.8 PIK60624.1 - 0.023 13.1 3.8 0.028 12.8 3.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Med19 PF10278.9 PIK60624.1 - 0.024 14.6 8.0 0.031 14.2 8.0 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RR_TM4-6 PF06459.12 PIK60624.1 - 0.097 12.5 11.8 0.12 12.2 11.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1509 PF07420.11 PIK60624.1 - 0.23 10.4 5.3 0.3 10.0 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Myc_N PF01056.18 PIK60624.1 - 0.32 10.8 8.1 0.4 10.5 8.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region CDC45 PF02724.14 PIK60624.1 - 0.44 8.8 15.9 0.51 8.6 15.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.11 PIK60624.1 - 0.45 10.5 26.5 0.63 10.0 26.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CENP-N PF05238.13 PIK60624.1 - 0.48 9.7 6.0 0.56 9.4 6.0 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like PMSI1 PF15322.6 PIK60624.1 - 0.54 9.7 7.6 0.66 9.4 7.6 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DUF3381 PF11861.8 PIK60624.1 - 0.59 9.9 20.5 0.81 9.5 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Herpes_DNAp_acc PF04929.12 PIK60624.1 - 2.2 7.2 4.5 2.4 7.0 4.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PAC1 PF16094.5 PIK60624.1 - 3.5 6.7 9.6 5.7 6.0 9.6 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Astro_capsid_p PF12226.8 PIK60624.1 - 4.4 6.4 9.8 5.5 6.0 9.8 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Connexin PF00029.19 PIK60624.1 - 6.2 6.5 5.8 7.9 6.2 5.8 1.2 1 0 0 1 1 1 0 Connexin Hid1 PF12722.7 PIK60624.1 - 6.6 4.7 6.4 7 4.6 6.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 PIK60624.1 - 8.5 5.0 8.4 8.9 5.0 8.4 1.1 1 0 0 1 1 1 0 Presenilin Spt5_N PF11942.8 PIK60625.1 - 0.03 15.3 4.3 0.03 15.3 4.3 4.0 2 1 1 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal DUF1639 PF07797.14 PIK60625.1 - 0.16 12.0 0.9 0.35 10.9 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Drc1-Sld2 PF11719.8 PIK60625.1 - 0.24 10.9 6.4 0.27 10.7 6.4 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein Nop53 PF07767.11 PIK60625.1 - 0.25 10.7 10.9 0.48 9.8 10.9 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CCSAP PF15748.5 PIK60625.1 - 0.33 11.1 4.7 0.41 10.8 4.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Astro_capsid_p PF12226.8 PIK60625.1 - 8 5.5 14.3 13 4.8 14.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Spt5-NGN PF03439.13 PIK60626.1 - 1e-26 92.6 0.2 2.2e-26 91.6 0.2 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 PIK60626.1 - 1.9e-26 91.1 9.6 5.9e-08 32.4 3.9 5.9 5 1 0 5 5 5 4 KOW motif DUF3912 PF13051.6 PIK60626.1 - 9e-05 22.7 3.6 0.006 16.8 0.0 3.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3912) SH3_1 PF00018.28 PIK60629.1 - 5e-12 45.2 0.3 5e-12 45.2 0.3 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 PIK60629.1 - 1.1e-09 38.0 0.4 1.1e-09 38.0 0.4 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK60629.1 - 2.8e-08 33.3 0.2 4.3e-08 32.7 0.2 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK60629.1 - 0.038 14.3 1.0 0.038 14.3 1.0 1.8 2 0 0 2 2 2 0 Bacterial SH3 domain eIF3_subunit PF08597.10 PIK60629.1 - 2.3 8.1 10.5 2.9 7.8 10.5 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit BAR_3_WASP_bdg PF10456.9 PIK60630.1 - 2.1e-56 191.0 0.1 3.1e-56 190.5 0.1 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 PIK60630.1 - 1.2e-05 25.3 0.1 0.00053 20.0 0.0 3.0 2 1 0 2 2 2 1 PX domain DUF2525 PF10733.9 PIK60630.1 - 0.16 12.3 1.0 1.6 9.1 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2525) Met_10 PF02475.16 PIK60631.1 - 2.2e-24 86.3 0.0 4e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 PIK60631.1 - 7.8e-05 22.3 0.0 0.00015 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 PIK60631.1 - 0.0011 18.6 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DNA_methylase PF00145.17 PIK60631.1 - 0.01 15.2 0.0 0.028 13.8 0.0 1.7 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase TRM PF02005.16 PIK60631.1 - 0.012 14.9 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase PrmA PF06325.13 PIK60631.1 - 0.013 14.9 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 PIK60631.1 - 0.023 14.7 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 PIK60631.1 - 0.093 13.4 0.0 0.31 11.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Caldesmon PF02029.15 PIK60632.1 - 0.014 14.2 56.2 0.02 13.7 56.2 1.2 1 0 0 1 1 1 0 Caldesmon WD40 PF00400.32 PIK60633.1 - 9.2e-22 76.9 4.0 0.00036 21.3 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60633.1 - 0.0061 16.8 0.0 0.45 10.9 0.0 3.5 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 PIK60634.1 - 2.1e-15 56.3 0.0 3.1e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK60634.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif NUFIP1 PF10453.9 PIK60635.1 - 1.3e-09 37.7 1.1 1.3e-09 37.7 1.1 3.1 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) p450 PF00067.22 PIK60636.1 - 1.1e-78 265.1 0.0 1.2e-78 265.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 COG6 PF06419.11 PIK60637.1 - 2.8e-208 693.1 7.5 3.4e-208 692.8 7.5 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 PIK60637.1 - 0.0074 16.2 2.7 0.0074 16.2 2.7 2.6 2 0 0 2 2 2 1 Sec34-like family YabA PF06156.13 PIK60637.1 - 0.14 12.8 6.0 0.075 13.7 1.4 2.8 2 1 0 2 2 2 0 Initiation control protein YabA Fzo_mitofusin PF04799.13 PIK60637.1 - 0.15 11.6 1.8 0.51 9.9 1.8 2.0 1 0 0 1 1 1 0 fzo-like conserved region sCache_like PF16736.5 PIK60637.1 - 0.24 11.5 2.0 2.7 8.1 0.1 2.9 2 1 0 3 3 3 0 Single Cache-like COG2 PF06148.11 PIK60637.1 - 4.9 7.2 8.3 0.24 11.5 1.1 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Muted PF14942.6 PIK60637.1 - 6.2 7.2 11.2 1.4 9.3 2.6 3.4 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein Sulfotransfer_1 PF00685.27 PIK60638.1 - 5.3e-16 58.9 0.0 8.4e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK60638.1 - 2.4e-11 44.5 0.0 9.3e-11 42.5 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK60639.1 - 4.8e-17 62.3 0.0 1.7e-16 60.5 0.0 1.8 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK60639.1 - 2.1e-07 31.5 0.0 3.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family YceD PF02620.17 PIK60639.1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Large ribosomal RNA subunit accumulation protein YceD RhoGEF PF00621.20 PIK60640.1 - 4.9e-47 160.5 5.8 8.7e-47 159.7 5.8 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_2 PF07653.17 PIK60640.1 - 2.3e-07 30.4 0.2 8.4e-07 28.6 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 PIK60640.1 - 2.8e-07 30.3 0.2 1.5e-06 27.9 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 PIK60640.1 - 1.6e-06 27.6 1.7 1.6e-06 27.6 1.7 2.1 2 0 0 2 2 2 1 SH3 domain SOG2 PF10428.9 PIK60641.1 - 5.4 6.1 28.8 6.1 5.9 28.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein PhoLip_ATPase_C PF16212.5 PIK60642.1 - 3.5e-70 236.6 34.1 3.5e-70 236.6 34.1 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 PIK60642.1 - 1.3e-12 48.5 0.5 4.9e-08 33.5 0.2 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 PIK60642.1 - 3e-12 46.5 0.0 1.5e-11 44.2 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 PIK60642.1 - 5.2e-11 42.4 0.0 1.3e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 PIK60642.1 - 7.7e-06 25.8 0.1 0.003 17.4 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 PIK60642.1 - 0.052 13.6 0.3 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase CC2-LZ PF16516.5 PIK60642.1 - 0.079 13.3 0.4 0.21 12.0 0.4 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HAD PF12710.7 PIK60642.1 - 0.084 13.3 0.0 23 5.3 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4404 PF14357.6 PIK60642.1 - 0.25 12.0 6.6 0.16 12.6 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Peptidase_C54 PF03416.19 PIK60643.1 - 1.7e-101 339.3 0.0 2e-101 339.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 PIK60643.1 - 0.3 10.5 1.1 1.1 8.7 1.1 1.9 1 1 0 1 1 1 0 Peptidase family C78 Astacin PF01400.24 PIK60644.1 - 6.6e-09 35.7 0.2 6.6e-09 35.7 0.2 1.8 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) CUB PF00431.20 PIK60645.1 - 6.2e-45 152.1 0.0 2.6e-23 82.4 0.0 3.2 3 0 0 3 3 3 3 CUB domain FXa_inhibition PF14670.6 PIK60645.1 - 3.4e-21 75.2 40.5 8.4e-08 32.4 9.5 3.6 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK60645.1 - 3.9e-18 65.4 41.4 3.2e-09 36.9 8.9 3.5 3 0 0 3 3 3 3 Calcium-binding EGF domain cEGF PF12662.7 PIK60645.1 - 2.2e-14 53.0 18.4 1.3e-07 31.4 1.2 3.8 3 0 0 3 3 3 3 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK60645.1 - 0.00081 19.5 33.9 0.083 13.1 4.0 4.2 3 1 1 4 4 4 2 EGF domain EGF PF00008.27 PIK60645.1 - 0.0017 18.6 33.6 0.0036 17.6 7.8 3.7 3 0 0 3 3 3 2 EGF-like domain Tme5_EGF_like PF09064.10 PIK60645.1 - 0.0036 17.2 21.0 0.017 15.0 4.8 3.0 2 1 0 2 2 2 2 Thrombomodulin like fifth domain, EGF-like Spheroidin PF05541.12 PIK60645.1 - 5.9 4.6 8.0 8.1 4.1 8.0 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein RhoGEF PF00621.20 PIK60646.1 - 1.7e-24 87.0 10.8 1e-12 48.6 0.7 2.6 2 1 1 3 3 3 2 RhoGEF domain PH PF00169.29 PIK60646.1 - 6.4e-05 23.4 6.2 6.4e-05 23.4 6.2 2.4 2 1 0 2 2 2 1 PH domain PH_10 PF15411.6 PIK60646.1 - 0.0012 19.1 3.4 0.0061 16.8 3.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 PIK60646.1 - 0.016 15.1 3.2 0.088 12.8 3.2 2.1 1 1 0 1 1 1 0 PH domain PH_8 PF15409.6 PIK60646.1 - 0.054 13.8 0.2 0.2 11.9 0.2 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_HK97_TLTM PF06120.11 PIK60647.1 - 0.089 12.0 0.4 0.16 11.2 0.4 1.3 1 0 0 1 1 1 0 Tail length tape measure protein CRAL_TRIO_2 PF13716.6 PIK60648.1 - 0.00026 21.1 0.0 0.0005 20.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RVT_1 PF00078.27 PIK60650.1 - 4.6e-11 42.7 0.2 6.9e-05 22.5 0.1 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD PF12009.8 PIK60650.1 - 1.1e-08 35.3 0.0 5.9e-08 32.9 0.0 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain Sulfotransfer_2 PF03567.14 PIK60651.1 - 2.3e-17 63.7 0.0 3.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK60652.1 - 3.6e-22 79.5 0.4 4.4e-22 79.2 0.4 1.0 1 0 0 1 1 1 1 Sulfotransferase family DUF3453 PF11935.8 PIK60652.1 - 0.011 15.4 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3453) FeoB_N PF02421.18 PIK60652.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.22 PIK60653.1 - 3e-38 131.0 0.0 3.7e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK60653.1 - 1.7e-21 76.6 0.0 2.2e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK60653.1 - 5.7e-06 25.9 0.0 1e-05 25.1 0.0 1.2 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 PIK60653.1 - 0.05 13.0 0.0 0.066 12.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 PIK60653.1 - 0.056 13.0 0.0 0.076 12.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region C2-set_2 PF08205.12 PIK60654.1 - 8.4e-06 25.8 3.1 0.12 12.5 0.6 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK60654.1 - 0.0079 16.4 0.1 0.14 12.3 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK60654.1 - 0.034 14.8 2.7 13 6.4 0.0 4.3 4 1 0 4 4 4 0 Immunoglobulin domain ig PF00047.25 PIK60654.1 - 0.55 10.4 4.9 48 4.2 0.1 4.3 4 0 0 4 4 4 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK60655.1 - 3.8e-09 36.5 0.3 0.00022 21.2 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK60655.1 - 4.1e-05 23.9 0.4 0.0005 20.4 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 PIK60655.1 - 0.0012 19.4 0.2 0.02 15.5 0.0 2.7 2 1 1 3 3 3 1 Immunoglobulin domain Cupredoxin_1 PF13473.6 PIK60655.1 - 0.072 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Cupredoxin-like domain Pkinase_Tyr PF07714.17 PIK60656.1 - 1.8e-28 99.6 0.0 2.5e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60656.1 - 4.7e-20 72.1 0.1 7.7e-20 71.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 PIK60657.1 - 8.4e-16 58.1 0.5 4.3e-06 26.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK60657.1 - 4.7e-10 39.9 0.4 0.057 14.0 0.0 4.8 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK60657.1 - 4.2e-07 30.1 0.5 0.16 12.1 0.1 4.6 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK60657.1 - 4.3e-05 23.5 0.1 0.021 14.9 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin I-set domain DcuC PF03606.15 PIK60657.1 - 0.0084 14.6 0.1 0.013 14.0 0.1 1.2 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier Peptidase_M73 PF12389.8 PIK60657.1 - 0.019 14.8 0.1 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase DUF4448 PF14610.6 PIK60657.1 - 0.062 13.1 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) PRIMA1 PF16101.5 PIK60657.1 - 0.097 12.7 0.3 5.4 7.1 0.2 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DED PF01335.21 PIK60658.1 - 5.2e-11 42.7 0.0 0.00033 20.9 0.0 3.6 3 0 0 3 3 3 3 Death effector domain Pkinase_Tyr PF07714.17 PIK60659.1 - 2.2e-43 148.4 0.1 2.8e-43 148.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60659.1 - 2.7e-18 66.3 0.1 3.8e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK60660.1 - 4.7e-05 23.9 1.7 0.67 10.6 0.1 3.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK60660.1 - 7.3e-05 22.9 1.0 0.77 10.0 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin V-set domain I-set PF07679.16 PIK60660.1 - 0.00025 21.0 0.4 1.1 9.4 0.2 3.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK60660.1 - 0.00073 19.6 0.0 0.0023 18.0 0.0 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF5017 PF16409.5 PIK60660.1 - 0.0057 16.2 0.4 0.014 14.8 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5017) Exo_endo_phos_2 PF14529.6 PIK60661.1 - 3.5e-07 30.1 0.2 6e-07 29.3 0.2 1.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase LIFR_N PF18207.1 PIK60661.1 - 0.031 14.7 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 Leukemia inhibitory factor receptor N-terminal domain Nod_GRP PF07806.11 PIK60661.1 - 1.5 8.7 4.2 3 7.7 4.2 1.4 1 0 0 1 1 1 0 Nodule-specific GRP repeat Pkinase_Tyr PF07714.17 PIK60662.1 - 7.2e-19 68.1 0.4 1.3e-18 67.2 0.4 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase ig PF00047.25 PIK60662.1 - 1.3e-06 28.4 2.8 3.6e-05 23.9 0.4 3.2 2 1 1 3 3 3 1 Immunoglobulin domain Pkinase PF00069.25 PIK60662.1 - 6.7e-06 25.7 0.1 1.1e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK60662.1 - 1.5e-05 25.5 0.7 0.0013 19.3 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60662.1 - 7.3e-05 23.0 0.5 0.0011 19.3 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 PIK60662.1 - 0.045 14.1 1.3 0.51 10.7 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK60662.1 - 0.066 13.3 0.3 0.23 11.6 0.1 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain NDK PF00334.19 PIK60663.1 - 0.12 12.4 0.0 0.36 10.8 0.0 1.8 1 0 0 1 1 1 0 Nucleoside diphosphate kinase RXT2_N PF08595.11 PIK60663.1 - 0.75 9.8 5.1 1.5 8.8 4.0 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal A_deamin PF02137.18 PIK60664.1 - 4.8e-38 131.4 0.1 8.4e-38 130.6 0.1 1.4 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 PIK60664.1 - 5.8e-27 94.2 0.4 7.5e-13 49.0 0.0 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif TbpB_B_D PF01298.18 PIK60664.1 - 0.0068 16.8 0.3 3 8.2 0.1 2.4 2 0 0 2 2 2 2 C-lobe and N-lobe beta barrels of Tf-binding protein B DND1_DSRM PF14709.7 PIK60664.1 - 0.013 15.8 3.9 0.23 11.8 0.4 3.0 2 2 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 Acyl-CoA_dh_1 PF00441.24 PIK60665.1 - 4.3e-42 143.9 0.1 6.3e-42 143.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK60665.1 - 1.2e-30 106.4 0.1 2.7e-30 105.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK60665.1 - 2e-27 95.2 0.0 3.8e-27 94.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK60665.1 - 8.2e-11 42.3 0.0 1.3e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Tsg PF04668.12 PIK60665.1 - 0.056 14.1 0.5 0.099 13.3 0.5 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region Ank_2 PF12796.7 PIK60668.1 - 7e-39 132.3 0.9 1.3e-11 44.9 0.0 5.1 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK60668.1 - 1.6e-30 105.1 5.0 5.7e-10 39.5 0.0 5.9 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK60668.1 - 1.6e-30 104.7 3.0 6.1e-08 32.8 0.0 6.8 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK60668.1 - 2.9e-26 90.7 7.0 1.8e-05 25.0 0.0 8.5 8 1 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 PIK60668.1 - 1.1e-22 77.7 8.8 0.00089 19.5 0.0 8.8 7 1 1 8 8 8 5 Ankyrin repeat TPR_2 PF07719.17 PIK60668.1 - 1.7e-05 24.6 2.0 0.37 11.0 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 PIK60668.1 - 0.00046 19.9 3.3 0.5 10.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK60668.1 - 0.00099 18.7 0.1 5.1 6.9 0.0 3.3 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.6 PIK60668.1 - 0.0053 16.9 0.3 5.6 7.4 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK60668.1 - 0.0056 17.4 1.2 0.023 15.5 1.2 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK60668.1 - 0.025 14.7 0.2 0.068 13.3 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat RFX_DNA_binding PF02257.15 PIK60669.1 - 5.3e-25 87.9 0.1 7.3e-25 87.4 0.1 1.2 1 0 0 1 1 1 1 RFX DNA-binding domain RFX5_N PF18326.1 PIK60669.1 - 3.1e-09 36.4 0.3 6.8e-09 35.4 0.2 1.6 1 1 1 2 2 2 1 RFX5 N-terminal domain Pox_D5 PF03288.16 PIK60669.1 - 0.088 13.3 0.1 0.42 11.1 0.0 1.9 1 1 1 2 2 2 0 Poxvirus D5 protein-like Cdc6_C PF09079.11 PIK60669.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain FA_hydroxylase PF04116.13 PIK60670.1 - 4.5e-25 88.5 8.4 4.5e-25 88.5 8.4 2.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Kinesin PF00225.23 PIK60671.1 - 5.2e-37 127.5 0.1 6.2e-37 127.3 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK60671.1 - 1.1e-19 70.9 0.3 1.6e-16 60.6 0.0 2.3 2 1 0 2 2 2 2 Microtubule binding ApoA-II PF04711.13 PIK60671.1 - 0.056 13.6 0.1 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) Alpha_E1_glycop PF01589.16 PIK60671.1 - 0.14 10.7 0.0 0.22 10.1 0.0 1.2 1 0 0 1 1 1 0 Alphavirus E1 glycoprotein rve PF00665.26 PIK60672.1 - 6.3e-23 81.2 0.0 1.3e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60672.1 - 2.2e-15 56.5 3.1 1.9e-14 53.5 1.5 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 PIK60672.1 - 2e-05 24.3 0.1 6e-05 22.7 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK60672.1 - 0.032 14.5 0.1 0.062 13.5 0.1 1.4 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK60673.1 - 1.5e-16 60.6 0.0 2.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MKLP1_Arf_bdg PF16540.5 PIK60674.1 - 4.5e-26 91.0 0.7 1.1e-25 89.8 0.7 1.7 1 0 0 1 1 1 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Kinesin PF00225.23 PIK60674.1 - 2.6e-16 59.5 0.0 5.7e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain DUF4407 PF14362.6 PIK60674.1 - 2.4 7.4 9.6 3.7 6.8 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tubulin-binding PF00418.19 PIK60675.1 - 6.2e-76 250.0 56.6 9.6e-15 54.3 0.8 10.7 10 1 0 10 10 10 9 Tau and MAP protein, tubulin-binding repeat Lectin_C PF00059.21 PIK60676.1 - 2.9e-50 169.5 7.9 1.2e-12 48.5 0.0 6.6 5 2 1 6 6 6 6 Lectin C-type domain Churchill PF06573.11 PIK60677.1 - 0.18 12.2 0.4 0.26 11.6 0.4 1.2 1 0 0 1 1 1 0 Churchill protein DUF4371 PF14291.6 PIK60679.1 - 1.1e-05 25.3 0.1 1.7e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 PIK60679.1 - 0.00016 21.5 0.1 0.00037 20.4 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) MAP65_ASE1 PF03999.12 PIK60679.1 - 0.18 10.4 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) zf-CCCH PF00642.24 PIK60680.1 - 3.3e-09 36.4 2.6 3.3e-09 36.4 2.6 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 PIK60680.1 - 1.4e-07 31.2 9.7 2.4e-07 30.5 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK60680.1 - 7.8e-06 25.6 12.3 1.5e-05 24.7 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK60680.1 - 1.3e-05 25.0 14.4 2.2e-05 24.3 14.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 PIK60680.1 - 3.9e-05 23.4 13.0 8e-05 22.4 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 PIK60680.1 - 9.4e-05 22.3 5.0 9.4e-05 22.3 5.0 2.1 2 0 0 2 2 1 1 Zinc finger domain zf-RING_2 PF13639.6 PIK60680.1 - 0.00018 21.8 11.2 0.00037 20.8 11.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 PIK60680.1 - 0.00035 20.6 9.4 0.00085 19.4 9.4 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 PIK60680.1 - 0.0034 17.4 12.2 0.0077 16.2 12.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-CCCH_4 PF18044.1 PIK60680.1 - 0.0052 16.5 3.2 0.0052 16.5 3.2 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 PIK60680.1 - 0.012 15.5 9.9 0.022 14.6 9.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 PIK60680.1 - 0.024 14.5 5.4 0.043 13.6 5.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-CCCH_2 PF14608.6 PIK60680.1 - 0.03 14.8 3.1 0.086 13.3 3.1 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-RING_10 PF16685.5 PIK60680.1 - 0.11 12.6 9.6 0.052 13.7 7.2 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 PIK60680.1 - 0.89 9.3 7.2 1.8 8.3 7.2 1.4 1 0 0 1 1 1 0 P-11 zinc finger CHCH PF06747.13 PIK60681.1 - 8.4e-07 29.0 2.1 8.4e-07 29.0 2.1 2.8 3 0 0 3 3 3 2 CHCH domain CX9C PF16860.5 PIK60681.1 - 0.0015 18.5 9.6 0.036 14.1 1.5 2.4 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 PIK60681.1 - 0.4 10.7 10.6 0.84 9.7 1.3 2.7 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 PIK60681.1 - 0.83 10.0 11.3 1.2 9.5 1.2 2.8 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 PIK60681.1 - 5.6 6.8 9.9 0.32 10.7 2.1 2.2 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF4580 PF15162.6 PIK60682.1 - 0.018 14.6 0.1 0.026 14.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) ATP-gua_Ptrans PF00217.19 PIK60684.1 - 8.8e-77 257.3 0.0 2.2e-76 256.0 0.0 1.6 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 PIK60684.1 - 6.7e-13 48.8 0.0 1.6e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain LRR_6 PF13516.6 PIK60686.1 - 2e-11 43.0 1.8 0.031 14.3 0.1 5.9 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 PIK60686.1 - 0.00025 21.1 1.2 1.6e+02 3.5 0.1 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 PIK60686.1 - 0.0011 19.3 2.2 2.5 8.7 0.2 4.5 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) Acetyltransf_CG PF14542.6 PIK60687.1 - 1.1e-21 76.8 0.0 1.3e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 PIK60687.1 - 0.06 12.8 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Ldh_1_C PF02866.18 PIK60687.1 - 0.089 12.7 0.0 0.093 12.7 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain zinc_ribbon_10 PF10058.9 PIK60688.1 - 8.9e-14 51.0 0.5 1.6e-13 50.2 0.5 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Mu-like_Com PF10122.9 PIK60688.1 - 0.011 15.1 0.1 0.031 13.7 0.1 1.8 1 0 0 1 1 1 0 Mu-like prophage protein Com TFIIF_alpha PF05793.12 PIK60688.1 - 0.053 12.1 0.2 0.075 11.6 0.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-tcix PF14952.6 PIK60688.1 - 0.16 11.6 0.9 0.43 10.2 0.9 1.7 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding Herpes_LMP1 PF05297.11 PIK60688.1 - 2 7.5 16.0 0.081 12.1 1.9 2.2 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Exo_endo_phos PF03372.23 PIK60689.1 - 0.019 14.5 0.0 1.2 8.6 0.0 2.1 1 1 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family GATA PF00320.27 PIK60690.1 - 7.6e-05 22.2 1.6 0.00018 21.0 1.6 1.7 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 PIK60690.1 - 0.025 14.9 3.3 0.053 13.8 3.3 1.5 1 0 0 1 1 1 0 zinc-ribbon COLFI PF01410.18 PIK60691.1 - 1.5e-73 247.0 0.0 1.9e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Collagen PF01391.18 PIK60691.1 - 4.5e-31 106.4 110.9 5.8e-09 35.6 18.9 4.3 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK60692.1 - 5.3e-15 54.9 54.9 1.3e-08 34.5 23.6 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK60693.1 - 1.2e-99 326.0 382.0 1.6e-08 34.1 30.3 13.7 1 1 4 5 5 5 3 Collagen triple helix repeat (20 copies) DUF1522 PF07482.11 PIK60695.1 - 0.025 14.9 0.2 5.4 7.4 0.1 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1522) DUF3717 PF12512.8 PIK60695.1 - 0.046 13.6 0.1 26 4.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3717) Collagen PF01391.18 PIK60696.1 - 5e-138 449.0 660.7 4.5e-09 35.9 30.3 20.4 4 2 11 15 15 15 12 Collagen triple helix repeat (20 copies) COLFI PF01410.18 PIK60696.1 - 6.1e-56 189.3 0.8 2e-54 184.4 0.8 2.1 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain PID PF00640.23 PIK60698.1 - 1.3e-16 60.9 0.2 3e-16 59.7 0.2 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Cnn_1N PF07989.11 PIK60698.1 - 0.0074 16.4 2.0 0.014 15.5 2.0 1.4 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 APP_E2 PF12925.7 PIK60698.1 - 0.011 15.5 0.7 0.016 14.9 0.7 1.2 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein HAP1_N PF04849.13 PIK60698.1 - 0.019 14.2 1.9 0.028 13.6 1.9 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region PID_2 PF14719.6 PIK60698.1 - 0.03 14.2 0.1 0.045 13.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) GIT_CC PF16559.5 PIK60698.1 - 0.045 13.6 0.2 0.088 12.7 0.2 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 PIK60698.1 - 0.047 13.5 2.3 0.11 12.3 2.3 1.6 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.21 PIK60698.1 - 0.049 13.7 2.1 0.11 12.7 2.1 1.5 1 0 0 1 1 1 0 bZIP transcription factor CCDC85 PF10226.9 PIK60698.1 - 0.053 13.2 0.3 0.053 13.2 0.3 1.6 2 0 0 2 2 2 0 CCDC85 family FlaC_arch PF05377.11 PIK60698.1 - 0.072 13.5 0.5 0.17 12.3 0.5 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Dna2 PF08696.11 PIK60698.1 - 0.078 12.8 0.8 0.11 12.2 0.8 1.2 1 0 0 1 1 1 0 DNA replication factor Dna2 YabA PF06156.13 PIK60698.1 - 0.093 13.4 1.3 0.18 12.5 1.3 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Hom_end PF05204.14 PIK60698.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Homing endonuclease Spc24 PF08286.11 PIK60698.1 - 0.16 12.2 1.8 0.32 11.3 1.8 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 XhlA PF10779.9 PIK60698.1 - 0.2 11.9 0.9 0.38 11.0 0.9 1.5 1 0 0 1 1 1 0 Haemolysin XhlA CENP-H PF05837.12 PIK60698.1 - 0.43 11.0 2.5 0.76 10.2 2.5 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) TED_complement PF07678.14 PIK60699.1 - 1.3e-103 346.3 0.0 1.9e-103 345.8 0.0 1.3 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK60699.1 - 1.6e-29 103.1 0.2 3.2e-28 98.8 0.1 3.2 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK60699.1 - 4e-28 97.1 0.1 9.7e-28 95.9 0.1 1.7 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 PIK60699.1 - 1.5e-26 92.9 0.2 6.6e-26 90.8 0.2 2.3 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain Methyltransf_FA PF12248.8 PIK60699.1 - 1.6e-13 50.8 0.0 4.6e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase MG3 PF17791.1 PIK60699.1 - 1e-11 44.9 0.4 5.5e-11 42.6 0.4 2.4 1 0 0 1 1 1 1 Macroglobulin domain MG3 MG4 PF17789.1 PIK60699.1 - 8e-10 38.7 0.0 3.6e-09 36.7 0.0 2.1 1 0 0 1 1 1 1 Macroglobulin domain MG4 Kazal_2 PF07648.15 PIK60699.1 - 5.2e-06 26.5 5.2 1.7e-05 24.9 5.2 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK60699.1 - 0.018 15.0 5.7 0.05 13.6 5.7 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain YjeF_N PF03853.15 PIK60700.1 - 3.3e-35 121.5 0.0 4.3e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus NAD_Gly3P_dh_C PF07479.14 PIK60701.1 - 4.7e-48 163.1 2.7 5e-48 163.0 0.6 2.1 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 PIK60701.1 - 1.7e-42 145.1 0.5 5.4e-42 143.4 0.0 2.0 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pox_VLTF3 PF04947.14 PIK60701.1 - 0.022 14.5 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like Guanylate_cyc PF00211.20 PIK60701.1 - 0.03 14.0 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain AcetDehyd-dimer PF09290.11 PIK60701.1 - 0.1 12.8 0.1 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation adh_short_C2 PF13561.6 PIK60702.1 - 3.8e-42 144.4 0.0 3.6e-41 141.3 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK60702.1 - 3e-30 105.1 0.1 5.9e-29 100.9 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase TOBE PF03459.17 PIK60702.1 - 0.09 13.1 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 TOBE domain RRM_1 PF00076.22 PIK60703.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 PIK60704.1 - 1.7e-10 40.6 0.0 2.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 PIK60704.1 - 0.044 14.0 0.0 0.68 10.1 0.0 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter ECH_2 PF16113.5 PIK60705.1 - 5.6e-43 147.7 0.0 7.4e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK60705.1 - 2.5e-19 69.6 0.0 3e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Imm47 PF15573.6 PIK60705.1 - 0.066 12.7 0.0 0.066 12.7 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 47 ECH_2 PF16113.5 PIK60706.1 - 1.6e-61 208.7 0.0 1.8e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_C6 PF00851.18 PIK60706.1 - 0.0023 16.9 0.1 0.0027 16.7 0.1 1.1 1 0 0 1 1 1 1 Helper component proteinase Peptidase_M24 PF00557.24 PIK60707.1 - 5.2e-51 173.3 0.1 6.3e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 TGS PF02824.21 PIK60707.1 - 2.1 8.5 3.8 37 4.5 0.0 3.0 3 0 0 3 3 3 0 TGS domain Acyl-CoA_dh_1 PF00441.24 PIK60708.1 - 9.8e-40 136.2 0.0 1.4e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK60708.1 - 8.2e-29 100.5 0.0 1.7e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK60708.1 - 1.6e-27 95.5 0.0 2.9e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 PIK60708.1 - 8.7e-09 35.7 0.0 1.5e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RVT_1 PF00078.27 PIK60709.1 - 1.1e-29 103.6 0.1 1.7e-29 103.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_CA PF07645.15 PIK60711.1 - 4.1e-36 122.9 139.4 1.6e-06 28.2 6.7 10.9 10 1 1 11 11 11 9 Calcium-binding EGF domain EGF_3 PF12947.7 PIK60711.1 - 1.2e-28 99.0 107.7 2.4e-06 27.6 5.4 10.2 8 1 1 9 9 9 8 EGF domain cEGF PF12662.7 PIK60711.1 - 2.3e-28 97.8 80.3 1e-05 25.4 7.1 9.9 9 0 0 9 9 9 7 Complement Clr-like EGF-like EGF PF00008.27 PIK60711.1 - 2.4e-16 59.7 110.4 0.00094 19.4 3.8 12.7 11 3 1 12 12 12 7 EGF-like domain FXa_inhibition PF14670.6 PIK60711.1 - 4.5e-13 49.2 90.5 8e-05 22.8 5.9 10.0 7 2 2 9 9 9 7 Coagulation Factor Xa inhibitory site SEA PF01390.20 PIK60711.1 - 1.2e-11 44.6 0.6 2.5e-11 43.6 0.6 1.5 1 0 0 1 1 1 1 SEA domain hEGF PF12661.7 PIK60711.1 - 1.2e-10 41.6 105.5 0.00028 21.4 4.9 13.3 13 1 1 14 14 14 8 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK60711.1 - 2.2e-05 24.4 79.6 0.0011 19.0 2.2 9.1 9 0 0 9 9 9 5 MSP1 EGF domain 1 NIDO PF06119.14 PIK60712.1 - 1.8e-13 51.2 9.0 2.9e-13 50.5 0.1 4.3 3 1 1 4 4 4 1 Nidogen-like EGF PF00008.27 PIK60712.1 - 2.1e-10 40.7 18.1 2.8e-09 37.1 2.6 4.7 5 0 0 5 5 5 2 EGF-like domain EGF_3 PF12947.7 PIK60712.1 - 1.6e-09 37.8 24.8 3.6e-09 36.7 12.7 3.0 2 0 0 2 2 2 2 EGF domain Sushi PF00084.20 PIK60712.1 - 1.7e-08 34.9 15.2 5.2e-06 27.0 0.6 3.6 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) EGF_CA PF07645.15 PIK60712.1 - 4.6e-08 33.1 27.2 1.9e-07 31.2 12.7 5.1 5 1 1 6 6 6 2 Calcium-binding EGF domain Ldl_recept_a PF00057.18 PIK60712.1 - 2.9e-05 24.2 5.9 2.9e-05 24.2 5.9 3.9 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A hEGF PF12661.7 PIK60712.1 - 0.00036 21.0 2.8 0.00036 21.0 2.8 5.2 4 0 0 4 4 4 2 Human growth factor-like EGF cEGF PF12662.7 PIK60712.1 - 0.67 9.9 23.1 0.061 13.3 4.2 5.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 PIK60712.1 - 1.5 9.0 22.4 0.068 13.2 6.6 3.8 3 0 0 3 3 3 0 MSP1 EGF domain 1 Rab_bind PF16704.5 PIK60713.1 - 0.015 15.3 4.0 4.2 7.5 0.8 3.1 2 0 0 2 2 2 0 Rab binding domain Sulfotransfer_3 PF13469.6 PIK60714.1 - 7e-06 26.6 0.0 1.1e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Reticulon PF02453.17 PIK60715.1 - 2.3e-44 151.1 6.2 2.6e-44 150.9 6.2 1.0 1 0 0 1 1 1 1 Reticulon Phage_holin_3_6 PF07332.11 PIK60715.1 - 0.011 15.8 1.4 0.21 11.6 0.2 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III HTH_Crp_2 PF13545.6 PIK60715.1 - 0.063 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain FtsL PF04999.13 PIK60715.1 - 0.77 9.8 3.2 2.1 8.4 0.1 2.4 2 0 0 2 2 2 0 Cell division protein FtsL DUF962 PF06127.11 PIK60715.1 - 3.1 8.0 5.2 12 6.1 5.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF962) Pkinase PF00069.25 PIK60716.1 - 1.3e-67 227.9 0.0 2.3e-67 227.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60716.1 - 3.4e-35 121.6 0.0 4.9e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 PIK60716.1 - 7.2e-11 42.5 0.4 1.8e-10 41.2 0.4 1.7 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 PIK60716.1 - 1.4e-08 34.5 0.0 3.1e-07 30.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 PIK60716.1 - 0.013 14.5 0.5 0.021 13.8 0.5 1.3 1 1 0 1 1 1 0 Haspin like kinase domain PH_11 PF15413.6 PIK60716.1 - 0.048 14.1 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Pertus-S5-tox PF09276.10 PIK60716.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin S5 subunit SBP_bac_3 PF00497.20 PIK60717.1 - 3.4e-06 26.7 0.2 4e-06 26.4 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Fascin PF06268.13 PIK60717.1 - 0.053 13.8 0.5 0.36 11.1 0.1 2.0 1 1 1 2 2 2 0 Fascin domain Neur_chan_memb PF02932.16 PIK60718.1 - 3.9e-17 63.1 4.4 1.4e-15 58.0 4.4 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2849 PF11011.8 PIK60718.1 - 0.087 13.5 0.1 0.14 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2849) Glyco_hydro_79C PF16862.5 PIK60718.1 - 0.11 13.5 0.9 0.24 12.3 0.4 2.0 2 1 0 2 2 2 0 Glycosyl hydrolase family 79 C-terminal beta domain cNMP_binding PF00027.29 PIK60719.1 - 2.7e-06 27.3 0.1 5.7e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HABP4_PAI-RBP1 PF04774.15 PIK60719.1 - 0.56 11.1 4.1 0.45 11.4 0.9 2.4 3 0 0 3 3 3 0 Hyaluronan / mRNA binding family Alg6_Alg8 PF03155.15 PIK60720.1 - 2.3e-145 485.3 26.2 1.9e-141 472.4 26.2 2.0 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family HYR PF02494.16 PIK60721.1 - 2.6e-24 85.3 14.5 2e-12 47.3 0.1 2.7 3 0 0 3 3 3 2 HYR domain EGF PF00008.27 PIK60721.1 - 8.1e-22 77.2 158.1 1.3e-05 25.4 11.7 10.8 10 2 0 10 10 10 8 EGF-like domain hEGF PF12661.7 PIK60721.1 - 0.00028 21.4 148.3 0.016 15.8 3.6 14.4 11 5 1 12 12 12 8 Human growth factor-like EGF HYR PF02494.16 PIK60722.1 - 1.6e-06 28.3 1.5 0.00033 20.9 0.1 3.0 3 0 0 3 3 3 2 HYR domain CUB PF00431.20 PIK60722.1 - 0.00059 20.2 0.0 0.0016 18.7 0.0 1.6 2 0 0 2 2 2 1 CUB domain FGGY_C PF02782.16 PIK60723.1 - 1.7e-66 223.7 0.3 3e-66 222.9 0.3 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 PIK60723.1 - 1.6e-16 60.6 0.4 2.9e-16 59.8 0.4 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_N PF00370.21 PIK60724.1 - 3.2e-13 49.8 0.0 3.8e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Osmo_CC PF08946.10 PIK60724.1 - 0.032 14.5 0.6 0.074 13.3 0.3 1.7 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Pkinase_Tyr PF07714.17 PIK60725.1 - 1.4e-41 142.5 0.3 1.9e-41 142.1 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60725.1 - 6.3e-09 35.6 0.0 1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK60725.1 - 5.7e-07 30.1 3.2 0.048 14.2 0.1 3.4 2 1 1 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK60725.1 - 0.0083 16.5 2.1 0.1 13.0 0.4 3.0 2 1 1 3 3 3 1 Immunoglobulin C1-set domain Herpes_gp2 PF05955.11 PIK60725.1 - 0.0084 15.7 0.3 0.016 14.7 0.3 1.5 1 0 0 1 1 1 1 Equine herpesvirus glycoprotein gp2 Marek_A PF02124.15 PIK60725.1 - 0.04 13.8 0.1 0.069 13.0 0.1 1.5 1 1 0 1 1 1 0 Marek's disease glycoprotein A ig PF00047.25 PIK60725.1 - 0.13 12.4 0.9 7.3 6.8 0.2 2.7 2 1 0 2 2 2 0 Immunoglobulin domain NACHT PF05729.12 PIK60726.1 - 1.7e-13 50.8 0.0 3.4e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TMIE PF16038.5 PIK60726.1 - 0.0025 17.6 0.1 0.0082 16.0 0.1 1.9 1 0 0 1 1 1 1 TMIE protein Shisa PF13908.6 PIK60726.1 - 0.0054 17.0 0.1 0.018 15.3 0.1 1.9 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK60726.1 - 0.0084 16.0 0.0 0.029 14.3 0.0 1.9 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 PIK60726.1 - 0.0087 16.9 0.0 0.031 15.1 0.0 1.9 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain C2-set_2 PF08205.12 PIK60726.1 - 0.019 15.0 0.2 0.049 13.7 0.2 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK60726.1 - 0.033 14.4 0.1 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin V-set domain Tafi-CsgC PF10610.9 PIK60726.1 - 0.1 12.8 1.2 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 Thin aggregative fimbriae synthesis protein Aminotran_3 PF00202.21 PIK60727.1 - 1.3e-31 109.7 0.0 4.3e-24 84.9 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-III Aminotran_3 PF00202.21 PIK60728.1 - 0.13 10.9 0.0 0.15 10.7 0.0 1.0 1 0 0 1 1 1 0 Aminotransferase class-III THF_DHG_CYH_C PF02882.19 PIK60729.1 - 8.4e-55 184.5 0.6 1.1e-54 184.1 0.6 1.1 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 PIK60729.1 - 0.047 13.8 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 PIK60729.1 - 0.05 13.6 0.1 0.079 12.9 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase THF_DHG_CYH PF00763.23 PIK60730.1 - 2.6e-25 88.9 0.5 9.1e-25 87.2 0.5 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain C2 PF00168.30 PIK60731.1 - 8.7e-19 67.7 0.6 1.7e-18 66.8 0.1 1.8 2 0 0 2 2 2 1 C2 domain MASE1 PF05231.14 PIK60731.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 MASE1 Pcc1 PF09341.10 PIK60731.1 - 0.13 12.4 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 Transcription factor Pcc1 C2 PF00168.30 PIK60732.1 - 2.7e-06 27.6 0.0 2.8e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 C2 domain HYR PF02494.16 PIK60736.1 - 8.5e-44 147.8 101.0 8.6e-06 26.0 5.2 11.6 10 2 1 11 11 11 9 HYR domain GIY-YIG PF01541.24 PIK60737.1 - 1.4e-05 25.2 0.7 2.6e-05 24.4 0.7 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain THAP PF05485.12 PIK60738.1 - 1.5e-12 48.3 0.1 2.4e-12 47.6 0.1 1.4 1 0 0 1 1 1 1 THAP domain HYR PF02494.16 PIK60741.1 - 5.3e-13 49.1 18.1 8.9e-07 29.1 5.2 2.1 2 0 0 2 2 2 2 HYR domain DUF1314 PF07013.11 PIK60741.1 - 0.029 14.2 4.3 1.8 8.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1314) HCV_NS5a_1a PF08300.13 PIK60741.1 - 0.89 9.7 5.8 9.1 6.5 0.3 2.6 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a zinc finger domain Pkinase_Tyr PF07714.17 PIK60743.1 - 4.9e-35 121.1 0.0 8.8e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60743.1 - 5.5e-17 62.0 0.0 9.4e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK60743.1 - 4.1e-11 43.3 2.2 8.8e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK60743.1 - 0.00028 20.9 0.2 0.042 13.9 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK60743.1 - 0.022 15.1 3.1 0.23 11.8 0.4 2.8 3 0 0 3 3 3 0 Immunoglobulin domain Marek_A PF02124.15 PIK60743.1 - 0.024 14.5 0.1 0.045 13.6 0.1 1.6 1 1 0 1 1 1 0 Marek's disease glycoprotein A DUF3377 PF11857.8 PIK60744.1 - 8.7e-05 22.4 0.1 0.00014 21.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) TMEM154 PF15102.6 PIK60744.1 - 0.02 14.8 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Trp_dioxygenase PF03301.13 PIK60744.1 - 0.042 13.2 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase Insulin_TMD PF17870.1 PIK60744.1 - 0.065 13.3 0.2 0.13 12.4 0.2 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF2627 PF11118.8 PIK60744.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Pkinase_Tyr PF07714.17 PIK60746.1 - 1.3e-48 165.5 1.0 1.8e-48 165.1 1.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60746.1 - 1.5e-19 70.4 0.5 8.3e-19 68.0 0.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK60746.1 - 0.01 16.4 0.3 9.2 7.0 0.2 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK60747.1 - 0.0029 18.2 1.9 2.3 8.9 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain NACHT PF05729.12 PIK60748.1 - 1.2e-10 41.6 0.0 3.4e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 NACHT domain TsaE PF02367.17 PIK60748.1 - 6.4e-05 23.0 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SecY PF00344.20 PIK60748.1 - 0.00099 18.4 0.3 0.0021 17.4 0.3 1.5 1 0 0 1 1 1 1 SecY translocase Stevor PF17410.2 PIK60748.1 - 0.0088 15.6 0.5 0.021 14.4 0.5 1.6 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame RCR PF12273.8 PIK60748.1 - 0.013 16.2 2.2 0.016 15.9 0.0 2.2 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red UL42 PF17638.2 PIK60748.1 - 0.038 14.0 0.1 0.089 12.8 0.1 1.5 1 0 0 1 1 1 0 HCMV UL42 TMEM154 PF15102.6 PIK60748.1 - 0.046 13.6 1.0 0.077 12.9 0.1 1.8 2 0 0 2 2 2 0 TMEM154 protein family ResIII PF04851.15 PIK60748.1 - 0.1 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PspB PF06667.12 PIK60748.1 - 0.54 10.4 3.1 0.74 9.9 1.2 2.1 2 0 0 2 2 2 0 Phage shock protein B C2-set_2 PF08205.12 PIK60749.1 - 0.0098 15.9 0.4 0.038 14.1 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF3212 PF11486.8 PIK60749.1 - 0.08 13.0 0.1 0.19 11.7 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3212) C1-set PF07654.15 PIK60749.1 - 0.16 12.3 2.6 0.68 10.3 0.8 2.6 2 1 1 3 3 3 0 Immunoglobulin C1-set domain Pkinase_Tyr PF07714.17 PIK60750.1 - 7e-41 140.2 0.1 1e-40 139.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK60750.1 - 2.3e-18 66.5 0.0 3.3e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Amidohydro_3 PF07969.11 PIK60751.1 - 1.6e-56 192.8 0.0 5.3e-40 138.3 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 PIK60751.1 - 7.7e-19 68.2 0.0 5.3e-17 62.2 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 PIK60752.1 - 2.6e-40 139.3 0.0 3.2e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 PIK60752.1 - 4.6e-13 49.2 0.0 6.5e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 PIK60753.1 - 6.9e-41 141.2 0.0 7.1e-22 78.5 0.0 2.1 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 PIK60753.1 - 5.8e-12 45.6 0.2 9.7e-09 35.0 0.0 2.2 1 1 1 2 2 2 2 Amidohydrolase family MRP-L28 PF09812.9 PIK60754.1 - 5.7e-35 120.8 8.0 7e-35 120.5 8.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF4338 PF14236.6 PIK60754.1 - 0.65 9.2 3.4 0.78 8.9 1.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4338) HAUS5 PF14817.6 PIK60755.1 - 6.5e-88 296.1 33.3 2.1e-63 215.1 24.8 2.0 1 1 1 2 2 2 2 HAUS augmin-like complex subunit 5 DUF4706 PF15797.5 PIK60755.1 - 1.1 9.8 7.7 0.52 10.9 1.4 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4706) MitMem_reg PF13012.6 PIK60756.1 - 3.4e-24 85.4 1.1 4.9e-24 84.9 1.1 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 PIK60756.1 - 1.3e-06 28.3 0.1 2.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TRAM_LAG1_CLN8 PF03798.16 PIK60759.1 - 1.2e-08 34.9 7.4 1.6e-08 34.5 7.4 1.2 1 0 0 1 1 1 1 TLC domain Smg8_Smg9 PF10220.9 PIK60760.1 - 0.0009 17.7 0.0 0.0012 17.2 0.0 1.1 1 0 0 1 1 1 1 Smg8_Smg9 ABC_tran PF00005.27 PIK60760.1 - 0.0014 19.2 0.1 0.005 17.3 0.1 2.0 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 PIK60760.1 - 0.0041 17.7 0.0 0.0065 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 PIK60760.1 - 0.008 16.3 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK60760.1 - 0.029 14.4 0.5 0.1 12.6 0.1 2.1 3 0 0 3 3 3 0 Dynamin family NB-ARC PF00931.22 PIK60760.1 - 0.093 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain MeaB PF03308.16 PIK60760.1 - 0.097 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ten1_2 PF15490.6 PIK60761.1 - 2.1e-22 79.0 0.0 2.5e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Ten1 PF12658.7 PIK60761.1 - 0.084 12.8 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Telomere capping, CST complex subunit Ank_2 PF12796.7 PIK60762.1 - 4.6e-24 84.8 2.6 4.8e-12 46.3 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK60762.1 - 2.7e-19 69.3 0.7 0.00034 21.1 0.0 6.2 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 PIK60762.1 - 4.9e-18 64.7 4.0 5.7e-07 29.7 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 PIK60762.1 - 1.4e-16 60.3 2.6 1.4e-06 28.4 0.0 5.3 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK60762.1 - 1.3e-15 55.9 1.8 0.0032 17.8 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Phage_G PF02306.15 PIK60764.1 - 0.1 12.3 1.7 0.32 10.7 0.0 2.2 2 1 1 3 3 3 0 Major spike protein (G protein) zf-ZPR1 PF03367.13 PIK60765.1 - 2.3e-113 375.3 2.5 7e-58 195.0 0.1 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 PIK60765.1 - 0.0018 18.3 4.1 0.19 11.8 0.8 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_C7 PF14522.6 PIK60765.1 - 1.7 8.7 7.4 1.1 9.3 0.2 2.8 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c Zn-ribbon_8 PF09723.10 PIK60765.1 - 2.3 8.4 7.1 7.3 6.8 0.9 3.4 3 0 0 3 3 3 0 Zinc ribbon domain RNA_POL_M_15KD PF02150.16 PIK60765.1 - 3.7 7.5 8.2 1.1 9.2 0.1 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit GHMP_kinases_N PF00288.26 PIK60766.1 - 1.3e-15 57.3 1.2 3.3e-15 56.1 1.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain APG17 PF04108.12 PIK60766.1 - 0.0058 15.8 0.0 0.0081 15.3 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 PAS_8 PF13188.7 PIK60766.1 - 0.082 13.0 0.0 0.76 9.9 0.0 2.5 2 0 0 2 2 2 0 PAS domain Na_sulph_symp PF00939.19 PIK60767.1 - 1.9e-70 238.2 13.6 2.3e-70 238.0 13.6 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK60767.1 - 3.1e-20 72.6 5.3 3.1e-20 72.6 5.3 2.6 1 1 1 2 2 2 2 Citrate transporter DcuC PF03606.15 PIK60767.1 - 0.082 11.3 18.6 1.5 7.2 18.6 2.6 1 1 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Na_sulph_symp PF00939.19 PIK60768.1 - 7.8e-25 87.8 3.9 8.8e-25 87.7 3.9 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 PIK60768.1 - 3.5e-07 29.7 1.5 3.9e-07 29.6 0.9 1.4 1 1 0 1 1 1 1 Citrate transporter COMM_domain PF07258.14 PIK60769.1 - 5.1e-16 58.5 0.2 7.5e-16 58.0 0.2 1.3 1 0 0 1 1 1 1 COMM domain CSTF_C PF14304.6 PIK60769.1 - 0.017 14.7 0.1 2.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal WD40 PF00400.32 PIK60770.1 - 6e-20 71.2 2.0 3.5e-05 24.5 0.0 5.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60770.1 - 4.5e-12 46.1 3.7 0.0014 18.9 0.0 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 PIK60770.1 - 0.0066 15.2 0.0 0.011 14.5 0.0 1.5 1 1 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal CPSF_A PF03178.15 PIK60770.1 - 0.007 15.7 0.0 0.019 14.3 0.0 1.6 1 1 0 1 1 1 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 PIK60771.1 - 1.1e-09 38.5 0.0 0.0014 18.9 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK60771.1 - 7.4e-09 36.1 7.9 0.029 15.2 0.0 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat FAM104 PF15434.6 PIK60772.1 - 2 9.0 0.0 2 9.0 0.0 3.3 2 1 0 2 2 2 0 Family 104 UCH PF00443.29 PIK60773.1 - 6e-26 91.5 0.2 1.4e-25 90.3 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK60773.1 - 1.5e-14 54.4 2.0 1.5e-14 54.4 2.0 2.0 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PHD PF00628.29 PIK60773.1 - 4e-08 33.0 6.5 4e-08 33.0 6.5 3.2 3 0 0 3 3 3 1 PHD-finger Zf_RING PF16744.5 PIK60773.1 - 0.21 11.7 2.9 0.34 11.0 1.2 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger TTL PF03133.15 PIK60774.1 - 1.9e-31 109.3 0.0 2.4e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK60774.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 YheC/D like ATP-grasp NCU-G1 PF15065.6 PIK60775.1 - 5.3e-67 226.4 0.8 6.9e-67 226.0 0.8 1.0 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 TFA2_Winged_2 PF18121.1 PIK60776.1 - 0.058 13.1 0.4 0.26 11.0 0.3 2.2 1 1 0 1 1 1 0 TFA2 Winged helix domain 2 Calx-beta PF03160.14 PIK60777.1 - 5.2e-15 55.4 22.3 3.2e-07 30.5 0.2 5.7 6 0 0 6 6 6 4 Calx-beta domain DUF4843 PF16132.5 PIK60777.1 - 0.02 14.5 2.1 11 5.6 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4843) GARS_N PF02844.15 PIK60778.1 - 0.041 14.7 0.0 0.08 13.7 0.0 1.5 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain FimH_man-bind PF09160.10 PIK60780.1 - 0.027 14.1 0.5 18 5.0 0.0 3.2 2 1 0 3 3 3 0 FimH, mannose binding zf-Di19 PF05605.12 PIK60781.1 - 0.018 15.3 0.9 0.018 15.3 0.9 2.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Csm1_N PF18504.1 PIK60781.1 - 0.62 10.4 3.7 1.2 9.5 3.7 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain DUF4407 PF14362.6 PIK60781.1 - 1.1 8.6 5.7 1.6 8.0 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-CHY PF05495.12 PIK60781.1 - 9.2 6.8 13.0 1 9.9 3.2 2.5 2 0 0 2 2 2 0 CHY zinc finger FHA PF00498.26 PIK60782.1 - 2.8e-11 43.6 0.9 8.7e-11 42.0 0.9 1.9 1 0 0 1 1 1 1 FHA domain LPP PF04728.13 PIK60782.1 - 6.9 7.1 13.8 15 6.1 0.9 4.5 4 0 0 4 4 4 0 Lipoprotein leucine-zipper FimH_man-bind PF09160.10 PIK60783.1 - 1.9e-05 24.3 12.5 2 8.1 0.0 6.0 2 2 3 6 6 6 5 FimH, mannose binding CBP_BcsS PF17036.5 PIK60783.1 - 1.3 8.9 10.5 15 5.5 0.1 5.0 2 2 4 6 6 6 0 Cellulose biosynthesis protein BcsS EamA PF00892.20 PIK60784.1 - 8e-07 29.3 5.9 9.5e-07 29.1 5.9 1.1 1 0 0 1 1 1 1 EamA-like transporter family Vma12 PF11712.8 PIK60784.1 - 0.1 12.7 0.0 0.14 12.2 0.0 1.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Calx-beta PF03160.14 PIK60785.1 - 1.6e-12 47.4 3.3 1.1e-07 32.0 0.3 3.4 4 0 0 4 4 4 2 Calx-beta domain DUF4843 PF16132.5 PIK60785.1 - 0.053 13.1 0.8 1.2 8.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4843) Invasin_D3 PF09134.10 PIK60785.1 - 0.12 12.6 0.4 25 5.3 0.0 2.8 3 0 0 3 3 3 0 Invasin, domain 3 HYR PF02494.16 PIK60786.1 - 3.3e-11 43.4 0.7 7.5e-11 42.2 0.7 1.6 1 0 0 1 1 1 1 HYR domain TraP PF07296.11 PIK60786.1 - 0.75 8.9 1.9 1.4 8.1 1.9 1.3 1 0 0 1 1 1 0 TraP protein OATP PF03137.20 PIK60787.1 - 0.11 10.7 6.8 3.6 5.8 8.3 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family KH_1 PF00013.29 PIK60788.1 - 7.6e-44 147.4 7.7 7.9e-13 48.0 0.3 4.1 4 0 0 4 4 4 4 KH domain SLS PF14611.6 PIK60788.1 - 7.5e-06 25.9 0.3 0.0044 16.9 0.1 2.8 1 1 2 3 3 3 1 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 PIK60788.1 - 0.00041 20.2 6.3 0.05 13.5 0.0 3.1 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 PIK60788.1 - 0.011 15.6 6.6 19 5.2 0.0 3.8 3 1 0 3 3 3 0 KH domain AbiH PF14253.6 PIK60788.1 - 0.015 15.2 0.1 0.023 14.6 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DREPP PF05558.12 PIK60788.1 - 0.026 14.4 0.3 0.089 12.7 0.0 2.0 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide SH3_15 PF18346.1 PIK60788.1 - 0.035 14.4 0.1 0.36 11.2 0.0 2.3 2 1 0 2 2 2 0 Mind bomb SH3 repeat domain Bcr-Abl_Oligo PF09036.10 PIK60788.1 - 0.041 13.9 0.2 0.21 11.6 0.3 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain KH_5 PF13184.6 PIK60788.1 - 2.7 8.1 6.3 49 4.1 0.4 3.6 2 1 2 4 4 4 0 NusA-like KH domain KH_1 PF00013.29 PIK60789.1 - 2.4e-111 363.6 36.5 1.3e-14 53.8 0.2 11.4 11 0 0 11 11 11 11 KH domain KH_2 PF07650.17 PIK60789.1 - 1.6e-16 59.9 29.3 0.027 14.3 0.3 8.0 6 2 1 8 8 8 7 KH domain SLS PF14611.6 PIK60789.1 - 6.4e-10 39.2 6.7 4.1e-05 23.5 0.1 4.0 2 1 2 4 4 4 3 Mitochondrial inner-membrane-bound regulator KH_5 PF13184.6 PIK60789.1 - 0.0072 16.4 24.5 2.3 8.4 0.1 8.1 9 1 0 9 9 9 3 NusA-like KH domain Ku_C PF03730.14 PIK60789.1 - 0.087 13.5 1.7 0.92 10.2 0.1 3.4 4 0 0 4 4 4 0 Ku70/Ku80 C-terminal arm HeH PF12949.7 PIK60789.1 - 0.11 12.2 0.0 0.35 10.6 0.0 1.9 1 0 0 1 1 1 0 HeH/LEM domain TPR_2 PF07719.17 PIK60790.1 - 3.3e-11 42.4 0.0 0.0098 15.9 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK60790.1 - 2.5e-09 36.5 0.0 0.013 15.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK60790.1 - 3.2e-07 30.0 0.0 0.11 12.8 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 PIK60790.1 - 1.6e-05 25.3 0.0 0.00015 22.2 0.0 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 PIK60790.1 - 3e-05 24.1 0.0 0.011 16.1 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 PIK60790.1 - 3.2e-05 23.6 0.0 0.36 11.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK60790.1 - 0.0002 21.0 0.0 0.0015 18.1 0.0 2.4 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 PIK60790.1 - 0.002 18.3 0.0 1.6 9.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK60790.1 - 0.0079 16.8 0.0 0.053 14.2 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK60790.1 - 0.021 15.6 0.0 2 9.4 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 PIK60790.1 - 0.031 14.3 0.1 2.5 8.2 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF627) TPR_10 PF13374.6 PIK60790.1 - 0.041 13.7 0.2 1.4 8.9 0.2 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 PIK60790.1 - 0.046 13.9 0.0 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1681 PF07933.14 PIK60792.1 - 4.1e-47 159.6 0.0 5e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) LRR_6 PF13516.6 PIK60793.1 - 1.5e-31 105.7 17.7 0.0001 22.1 0.0 8.3 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 PIK60793.1 - 9e-08 32.3 12.7 0.027 14.9 0.1 5.6 3 2 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK60793.1 - 9e-06 25.6 1.5 24 6.0 0.0 7.0 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.6 PIK60793.1 - 0.0036 17.0 14.7 0.072 12.9 0.1 6.1 3 2 2 5 5 5 2 Leucine rich repeat LRR_2 PF07723.13 PIK60793.1 - 0.0056 17.3 2.4 53 4.7 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat MMPL PF03176.15 PIK60794.1 - 0.0012 17.9 2.4 0.0012 17.9 2.4 1.8 1 1 0 1 1 1 1 MMPL family Patched PF02460.18 PIK60795.1 - 8.7e-12 44.0 0.0 1.1e-11 43.7 0.0 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 PIK60795.1 - 2.3 8.0 11.1 0.038 13.8 4.1 1.6 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation Proteasome PF00227.26 PIK60796.1 - 8.7e-28 97.1 1.8 1.8e-20 73.2 0.1 2.0 2 0 0 2 2 2 2 Proteasome subunit Amidase_6 PF12671.7 PIK60796.1 - 0.13 12.3 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Putative amidase domain zf-C2H2 PF00096.26 PIK60797.1 - 6.6e-19 67.2 74.2 0.025 15.0 0.2 11.6 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK60797.1 - 7.4e-18 63.7 76.2 0.0014 19.3 0.3 11.6 11 0 0 11 11 11 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK60797.1 - 3.2e-12 46.3 78.7 0.0037 17.6 0.6 11.8 12 0 0 12 12 12 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK60797.1 - 2.8e-05 24.3 36.5 0.064 13.6 0.1 8.6 10 0 0 10 10 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 PIK60797.1 - 0.00026 21.3 26.4 0.0004 20.6 4.4 4.8 2 1 1 4 4 4 2 C2H2-type zinc ribbon zf-met PF12874.7 PIK60797.1 - 0.00071 19.9 40.7 0.019 15.3 0.2 9.6 10 0 0 10 10 10 3 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK60797.1 - 0.12 12.3 0.1 0.12 12.3 0.1 6.5 6 0 0 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain ADK_lid PF05191.14 PIK60797.1 - 0.15 12.1 0.2 0.15 12.1 0.2 4.3 5 1 1 6 6 6 0 Adenylate kinase, active site lid FOXP-CC PF16159.5 PIK60797.1 - 4.1 8.1 19.3 1.9 9.2 0.8 5.9 5 2 1 6 6 6 0 FOXP coiled-coil domain RNA_POL_M_15KD PF02150.16 PIK60797.1 - 6.6 6.7 14.0 0.19 11.6 1.0 3.9 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit zf-C2H2_3rep PF18868.1 PIK60797.1 - 8 7.2 29.4 0.12 13.1 5.9 5.5 4 1 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats CDC45 PF02724.14 PIK60797.1 - 8 4.6 8.9 15 3.8 8.9 1.3 1 0 0 1 1 1 0 CDC45-like protein CoA_trans PF01144.23 PIK60798.1 - 0.08 12.3 0.0 0.099 12.0 0.0 1.0 1 0 0 1 1 1 0 Coenzyme A transferase Spermine_synth PF01564.17 PIK60799.1 - 2.3e-73 245.6 0.0 8.9e-73 243.7 0.0 1.8 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 PIK60799.1 - 4.5e-22 77.7 0.2 8e-22 76.9 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 PIK60799.1 - 6.1e-05 23.7 0.0 0.00011 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 PIK60799.1 - 0.035 13.3 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_12 PF08242.12 PIK60799.1 - 0.035 14.8 0.0 0.088 13.6 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 PIK60799.1 - 0.048 13.3 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 PIK60799.1 - 0.048 14.3 0.0 0.12 13.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 PIK60799.1 - 0.14 13.2 0.0 0.3 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain C2 PF00168.30 PIK60801.1 - 4.2e-17 62.3 0.0 1.2e-16 60.8 0.0 1.9 1 0 0 1 1 1 1 C2 domain SMP_C2CD2L PF18696.1 PIK60801.1 - 1.3e-14 54.3 0.4 2e-14 53.7 0.4 1.3 1 0 0 1 1 1 1 Synaptotagmin-like, mitochondrial and lipid-binding domain Death PF00531.22 PIK60802.1 - 3.2e-12 46.5 0.3 5.9e-12 45.6 0.3 1.4 1 0 0 1 1 1 1 Death domain DUF2604 PF10790.9 PIK60802.1 - 0.00057 20.1 0.1 1.3 9.4 0.0 2.5 2 0 0 2 2 2 2 Protein of Unknown function (DUF2604) Exo_endo_phos_2 PF14529.6 PIK60803.1 - 2.1e-09 37.3 0.0 3.9e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK60803.1 - 2.5e-06 27.2 0.1 4.3e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PRD_Mga PF08270.11 PIK60803.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) PRD domain RVT_1 PF00078.27 PIK60804.1 - 1e-46 159.2 0.0 1.3e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Death PF00531.22 PIK60806.1 - 2.3e-12 46.9 2.5 2.6e-12 46.7 0.9 1.8 2 0 0 2 2 2 1 Death domain UPA PF17217.3 PIK60806.1 - 0.0049 16.8 0.0 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 UPA domain ALS_ss_C PF10369.9 PIK60806.1 - 0.071 13.3 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Small subunit of acetolactate synthase DED PF01335.21 PIK60807.1 - 0.00018 21.7 1.2 0.013 15.8 0.2 2.2 2 0 0 2 2 2 2 Death effector domain Peptidase_A17 PF05380.13 PIK60808.1 - 8.6e-22 77.9 0.0 1.3e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase RVT_1 PF00078.27 PIK60808.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK60809.1 - 2.4e-14 52.9 1.0 6.5e-14 51.5 1.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2_10 PF16588.5 PIK60809.1 - 4.3e-05 23.1 1.5 8e-05 22.3 1.5 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 PIK60809.1 - 0.26 11.4 1.1 0.52 10.5 1.1 1.4 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.26 PIK60810.1 - 1.6e-15 57.4 0.0 1.9e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK60810.1 - 0.0083 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain OS-D PF03392.13 PIK60812.1 - 0.028 14.5 0.7 0.2 11.7 0.2 2.0 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D vWA-TerF-like PF10138.9 PIK60812.1 - 0.2 11.7 0.0 1.6 8.8 0.0 1.9 2 0 0 2 2 2 0 vWA found in TerF C terminus NACHT PF05729.12 PIK60813.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain GPI2 PF06432.11 PIK60813.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Death PF00531.22 PIK60814.1 - 1.1e-12 48.0 2.6 2.5e-12 46.8 2.6 1.7 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 PIK60814.1 - 0.0012 19.2 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Phasin PF05597.11 PIK60815.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) zf-RRN7 PF11781.8 PIK60815.1 - 0.4 10.4 1.8 8 6.2 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2H2_4 PF13894.6 PIK60815.1 - 0.58 11.2 5.4 7.1 7.8 0.1 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger RtcR PF06956.11 PIK60816.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase Rap_GAP PF02145.15 PIK60817.1 - 2e-20 73.2 0.2 2.4e-20 72.9 0.2 1.1 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.22 PIK60818.1 - 8e-09 35.5 0.0 1.3e-05 25.0 0.0 2.8 1 1 1 2 2 2 2 CNH domain CNH PF00780.22 PIK60819.1 - 4.7e-10 39.5 0.1 7e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 CNH domain CBFD_NFYB_HMF PF00808.23 PIK60820.1 - 1.1e-13 51.3 0.5 2.5e-13 50.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK60820.1 - 3.1e-06 27.6 0.0 3.1e-06 27.6 0.0 2.4 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 PIK60820.1 - 0.0023 18.0 21.3 0.0028 17.7 21.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 PIK60820.1 - 0.0026 17.5 26.4 0.0033 17.2 26.4 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Myc_N PF01056.18 PIK60820.1 - 0.014 15.3 7.9 0.021 14.7 7.9 1.2 1 0 0 1 1 1 0 Myc amino-terminal region CDC27 PF09507.10 PIK60820.1 - 0.015 14.7 16.4 0.019 14.4 16.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Prothymosin PF03247.14 PIK60820.1 - 0.018 15.5 29.9 0.031 14.7 29.9 1.3 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF4746 PF15928.5 PIK60820.1 - 0.037 13.4 9.5 0.052 13.0 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 PIK60820.1 - 0.39 8.9 28.9 0.49 8.6 28.9 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 PIK60820.1 - 1.2 8.4 25.2 1.9 7.7 25.2 1.4 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 PIK60820.1 - 4.4 6.6 30.4 5.8 6.2 30.4 1.2 1 0 0 1 1 1 0 SDA1 DUF2076 PF09849.9 PIK60820.1 - 7.4 6.5 18.7 11 6.0 18.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SURF2 PF05477.11 PIK60820.1 - 9 5.9 22.7 13 5.4 22.7 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) EGF PF00008.27 PIK60821.1 - 1.6e-80 264.9 291.8 2e-06 28.0 9.0 20.7 21 0 0 21 21 21 18 EGF-like domain Laminin_G_2 PF02210.24 PIK60821.1 - 1.8e-32 112.5 10.8 1.7e-14 54.5 0.0 5.4 4 1 1 5 5 5 5 Laminin G domain hEGF PF12661.7 PIK60821.1 - 3.6e-29 100.3 249.6 1.9e-06 28.2 4.8 21.9 21 0 0 21 21 21 15 Human growth factor-like EGF Laminin_G_1 PF00054.23 PIK60821.1 - 2.6e-23 82.7 0.2 1e-11 45.2 0.0 4.3 4 1 0 4 4 4 3 Laminin G domain EGF_CA PF07645.15 PIK60821.1 - 5.9e-06 26.4 20.4 0.0001 22.4 5.2 20.1 11 7 8 19 19 19 7 Calcium-binding EGF domain EGF_2 PF07974.13 PIK60821.1 - 0.0051 17.1 310.7 0.012 16.0 9.4 18.8 17 1 1 18 18 18 11 EGF-like domain Syndecan PF01034.20 PIK60821.1 - 0.12 12.4 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain AAA_5 PF07728.14 PIK60822.1 - 4.2e-52 175.8 0.0 5.7e-18 65.2 0.0 5.4 5 0 0 5 5 5 5 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 PIK60822.1 - 6e-36 122.9 0.1 3.5e-16 59.3 0.0 4.0 4 0 0 4 4 3 2 Midasin AAA lid domain AAA_lid_5 PF17865.1 PIK60822.1 - 1.2e-29 102.5 0.0 3.9e-29 100.8 0.0 2.0 1 0 0 1 1 1 1 Midasin AAA lid domain AAA_7 PF12775.7 PIK60822.1 - 6e-11 42.2 0.2 0.00021 20.8 0.0 3.2 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_16 PF13191.6 PIK60822.1 - 1.6e-10 41.6 1.9 3.9e-06 27.4 0.1 3.4 3 0 0 3 3 2 2 AAA ATPase domain AAA_3 PF07726.11 PIK60822.1 - 3.3e-10 39.9 0.0 0.025 14.5 0.0 4.7 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 PIK60822.1 - 4.2e-10 39.7 0.0 0.018 15.1 0.0 4.6 4 0 0 4 4 4 2 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 PIK60822.1 - 2.5e-07 31.2 0.1 0.0051 17.2 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 PIK60822.1 - 4.2e-07 30.2 0.2 0.00039 20.5 0.0 3.3 3 0 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 PIK60822.1 - 2.3e-06 27.4 0.0 0.11 12.2 0.0 3.5 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_22 PF13401.6 PIK60822.1 - 4e-06 27.2 1.0 0.0068 16.7 0.0 3.4 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 PIK60822.1 - 8.8e-06 25.7 0.1 0.15 12.1 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 PIK60822.1 - 2.3e-05 24.9 0.6 0.11 13.0 0.1 3.1 2 0 0 2 2 2 2 ABC transporter AAA_6 PF12774.7 PIK60822.1 - 3.4e-05 23.0 0.1 0.013 14.5 0.0 3.5 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region AAA_30 PF13604.6 PIK60822.1 - 9e-05 22.3 0.1 4 7.1 0.0 4.3 5 0 0 5 5 4 1 AAA domain AAA_19 PF13245.6 PIK60822.1 - 0.00011 22.5 0.7 0.66 10.3 0.3 3.4 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 PIK60822.1 - 0.0002 21.3 0.1 0.52 10.2 0.0 2.9 2 0 0 2 2 2 2 NACHT domain DUF815 PF05673.13 PIK60822.1 - 0.00022 20.5 0.0 0.024 13.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 PIK60822.1 - 0.00077 20.0 0.1 0.88 10.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain HEAT_EZ PF13513.6 PIK60822.1 - 0.0029 18.1 1.9 3.7 8.2 0.0 3.2 3 0 0 3 3 2 2 HEAT-like repeat DEAD PF00270.29 PIK60822.1 - 0.0067 16.2 0.3 5.5 6.7 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase cobW PF02492.19 PIK60822.1 - 0.015 14.9 0.3 3.3 7.3 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 PIK60822.1 - 0.016 14.6 0.0 3.3 7.0 0.0 3.5 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 PIK60822.1 - 0.019 15.4 0.1 1.7 9.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 PIK60822.1 - 0.026 14.1 0.6 0.65 9.6 0.2 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_2 PF07724.14 PIK60822.1 - 0.028 14.5 0.1 16 5.5 0.0 3.4 3 1 0 3 3 3 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 PIK60822.1 - 0.034 14.3 0.1 15 5.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain Adaptin_N PF01602.20 PIK60822.1 - 0.042 12.4 0.3 0.079 11.5 0.3 1.3 1 0 0 1 1 1 0 Adaptin N terminal region T2SSE PF00437.20 PIK60822.1 - 0.043 12.9 0.8 2.5 7.1 0.1 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF3450 PF11932.8 PIK60822.1 - 0.074 12.4 0.5 0.15 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PduV-EutP PF10662.9 PIK60822.1 - 0.097 12.4 0.1 2.5 7.8 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 PIK60822.1 - 0.097 12.7 0.5 4.6 7.3 0.1 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain ATP_bind_1 PF03029.17 PIK60822.1 - 0.13 12.0 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_11 PF13086.6 PIK60822.1 - 1.7 8.4 5.7 21 4.8 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 PIK60823.1 - 2e-18 66.7 0.1 1.9e-08 34.4 0.0 4.3 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 PIK60823.1 - 1.1e-09 38.5 0.0 7e-09 35.9 0.0 2.4 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_16 PF13191.6 PIK60823.1 - 8.8e-06 26.2 2.5 0.068 13.5 0.0 4.3 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 PIK60823.1 - 4.3e-05 23.9 0.3 0.33 11.4 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 PIK60823.1 - 5.4e-05 23.3 0.0 0.00035 20.7 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain RsgA_GTPase PF03193.16 PIK60823.1 - 0.001 19.0 0.0 1 9.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 PIK60823.1 - 0.03 13.9 0.2 2.8 7.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 PIK60823.1 - 0.049 13.8 0.1 13 5.9 0.0 3.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 PIK60823.1 - 0.9 10.1 8.7 4.4 7.9 0.0 4.8 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 PIK60823.1 - 1.1 9.7 4.0 3.2 8.3 0.0 3.6 3 0 0 3 3 3 0 ABC transporter EF-hand_1 PF00036.32 PIK60824.1 - 1.1e-21 74.6 10.6 4.3e-07 29.0 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 PIK60824.1 - 2.1e-21 76.1 9.1 2e-15 57.0 1.9 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 PIK60824.1 - 9.1e-19 65.7 5.5 5e-05 22.9 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 PIK60824.1 - 1.1e-13 50.0 10.6 0.00016 21.0 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 PIK60824.1 - 1.6e-12 47.1 11.1 0.00025 20.8 0.2 4.2 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK60824.1 - 6.8e-05 23.2 6.0 0.17 12.2 0.8 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 PIK60824.1 - 0.027 14.4 9.5 3.1 7.8 0.1 3.7 2 2 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand S10_plectin PF03501.15 PIK60824.1 - 0.062 13.4 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 Plectin/S10 domain DUF5552 PF17706.1 PIK60824.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5552) Homez PF11569.8 PIK60824.1 - 0.17 11.4 1.2 0.38 10.3 0.2 2.1 2 1 1 3 3 3 0 Homeodomain leucine-zipper encoding, Homez SHOCT PF09851.9 PIK60824.1 - 6.4 6.7 6.3 20 5.1 0.0 3.1 4 0 0 4 4 4 0 Short C-terminal domain Torsin PF06309.11 PIK60826.1 - 2e-09 37.6 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Torsin DUF4325 PF14213.6 PIK60826.1 - 0.0068 16.1 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 STAS-like domain of unknown function (DUF4325) DUF3139 PF11337.8 PIK60826.1 - 0.021 15.5 1.0 0.049 14.3 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Ca_hom_mod PF14798.6 PIK60826.1 - 0.05 12.7 0.1 0.072 12.2 0.1 1.2 1 0 0 1 1 1 0 Calcium homeostasis modulator Hep_59 PF07052.11 PIK60827.1 - 5.4e-29 101.1 9.1 5.4e-29 101.1 9.1 2.5 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 Collagen PF01391.18 PIK60828.1 - 3e-115 376.0 417.5 7.9e-09 35.1 25.5 15.5 3 3 11 14 14 14 13 Collagen triple helix repeat (20 copies) COLFI PF01410.18 PIK60828.1 - 2.4e-39 135.0 0.1 5e-19 68.5 0.1 2.1 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain PPO1_DWL PF12142.8 PIK60828.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Polyphenol oxidase middle domain C2 PF00168.30 PIK60829.1 - 3.2e-37 126.9 1.8 4e-22 78.5 0.0 2.1 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 PIK60829.1 - 0.00027 20.5 0.1 0.48 10.0 0.0 2.2 2 0 0 2 2 2 2 CEP76 C2 domain RVT_1 PF00078.27 PIK60830.1 - 3.5e-20 72.5 0.0 4.7e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.14 PIK60830.1 - 8.4e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain DUF3613 PF12266.8 PIK60830.1 - 0.0038 17.0 0.4 0.41 10.5 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3613) Integrase_H2C2 PF17921.1 PIK60831.1 - 2.5e-09 37.1 0.1 4.4e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK60831.1 - 3.7e-06 27.1 0.0 8.5e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain MIF PF01187.18 PIK60832.1 - 1.7e-08 34.7 0.0 0.00011 22.5 0.1 2.2 2 0 0 2 2 2 2 Macrophage migration inhibitory factor (MIF) PDZ PF00595.24 PIK60833.1 - 1.2e-09 38.4 0.6 1.7e-08 34.7 0.2 2.5 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK60833.1 - 1.2e-05 25.1 0.8 2.2e-05 24.2 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK60833.1 - 0.019 15.3 0.1 0.052 13.9 0.1 1.7 1 0 0 1 1 1 0 PDZ domain RVT_1 PF00078.27 PIK60835.1 - 9.5e-11 41.6 0.1 0.00013 21.5 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TrmB PF01978.19 PIK60835.1 - 0.038 13.9 0.0 1.6 8.7 0.0 3.0 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB zf-CCHC PF00098.23 PIK60836.1 - 0.0085 16.1 4.9 0.0085 16.1 4.9 3.0 3 0 0 3 3 3 1 Zinc knuckle ApoLp-III PF07464.11 PIK60836.1 - 0.015 15.4 5.7 0.021 14.9 5.7 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Mu-like_Pro PF10123.9 PIK60836.1 - 0.058 12.9 2.5 0.073 12.6 2.5 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein MORN PF02493.20 PIK60837.1 - 6.9e-10 38.2 0.8 7.7e-07 28.6 0.2 3.0 3 0 0 3 3 3 2 MORN repeat Qn_am_d_aII PF14930.6 PIK60837.1 - 0.12 12.7 0.6 0.22 11.9 0.1 1.7 2 1 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain II rRNA_proc-arch PF13234.6 PIK60838.1 - 4.2e-31 108.9 1.3 4.4e-31 108.8 0.3 1.5 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 PIK60838.1 - 2.5e-22 79.3 0.0 5.7e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 PIK60839.1 - 6.2e-17 61.9 0.0 1.4e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK60839.1 - 3e-07 30.6 0.0 6.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ski2_N PF17911.1 PIK60839.1 - 5.8e-07 29.4 1.0 9.5e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 Ski2 N-terminal region PhoH PF02562.16 PIK60839.1 - 0.086 12.3 0.2 0.23 10.9 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein GOLGA2L5 PF15070.6 PIK60840.1 - 1.6e-63 215.4 107.0 4.3e-43 147.9 27.2 5.7 1 1 4 5 5 5 3 Putative golgin subfamily A member 2-like protein 5 bZIP_1 PF00170.21 PIK60840.1 - 0.0044 17.1 2.6 0.0044 17.1 2.6 9.4 9 1 1 10 10 10 3 bZIP transcription factor TPR_MLP1_2 PF07926.12 PIK60840.1 - 0.0066 16.5 8.7 0.0066 16.5 8.7 8.4 3 3 3 7 7 7 1 TPR/MLP1/MLP2-like protein Tektin PF03148.14 PIK60841.1 - 9.7e-08 31.1 0.1 1.1e-07 31.0 0.1 1.0 1 0 0 1 1 1 1 Tektin family Ras PF00071.22 PIK60842.1 - 1.5e-16 60.4 0.1 1.8e-16 60.2 0.1 1.1 1 0 0 1 1 1 1 Ras family CX9C PF16860.5 PIK60843.1 - 6.5e-15 54.9 11.4 6.3e-11 42.1 3.0 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 PIK60843.1 - 5.1e-06 26.5 6.2 0.00073 19.6 0.4 2.8 2 1 1 3 3 3 2 CHCH domain Cmc1 PF08583.10 PIK60843.1 - 0.00077 19.4 8.4 0.034 14.2 1.6 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 PIK60843.1 - 0.014 15.1 8.0 0.67 9.7 0.3 2.1 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX6B PF02297.17 PIK60843.1 - 0.27 11.5 10.1 0.28 11.5 0.4 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb COX17 PF05051.13 PIK60843.1 - 1.4 9.3 7.1 8.4 6.8 1.9 2.4 2 1 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 PIK60843.1 - 2.2 8.6 10.7 1.7e+02 2.5 10.1 2.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Pet191_N PF10203.9 PIK60843.1 - 4.1 7.8 8.1 9.1 6.7 6.7 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 E1-E2_ATPase PF00122.20 PIK60844.1 - 6.5e-19 68.1 0.0 3.2e-12 46.3 0.0 2.5 2 1 0 2 2 2 2 E1-E2 ATPase DHHC PF01529.20 PIK60844.1 - 8.9 6.4 10.1 1.2 9.2 0.2 3.3 4 0 0 4 4 4 0 DHHC palmitoyltransferase Hydrolase PF00702.26 PIK60845.1 - 1.6e-12 48.1 0.0 2.9e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 PIK60845.1 - 0.00037 20.3 0.0 0.15 11.8 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase O-FucT PF10250.9 PIK60847.1 - 4.2e-77 260.1 0.0 5e-77 259.9 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF5131 PF07505.11 PIK60847.1 - 0.006 16.1 0.1 0.0085 15.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF5131) Ctr PF04145.15 PIK60848.1 - 7.1e-33 114.3 8.2 1.8e-32 113.0 8.2 1.6 1 1 0 1 1 1 1 Ctr copper transporter family DUF3021 PF11457.8 PIK60848.1 - 0.0018 18.6 8.4 0.046 14.0 0.5 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3021) P2X_receptor PF00864.19 PIK60848.1 - 0.073 12.1 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 ATP P2X receptor ERGIC_N PF13850.6 PIK60848.1 - 0.24 11.8 3.1 0.24 11.8 0.2 2.4 2 1 1 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Oxidored_q4 PF00507.19 PIK60848.1 - 8.4 6.6 12.4 0.17 12.1 4.9 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 HCR PF07111.12 PIK60849.1 - 7.5e-19 67.3 47.6 1.1e-18 66.7 47.6 1.2 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) Filament PF00038.21 PIK60849.1 - 0.21 11.1 69.1 1.1 8.7 9.5 3.7 3 1 1 4 4 4 0 Intermediate filament protein HMMR_N PF15905.5 PIK60849.1 - 1.2 8.5 77.2 0.015 14.8 8.5 4.3 2 2 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal EGF PF00008.27 PIK60850.1 - 7.8e-25 86.8 36.5 6.6e-09 35.9 8.8 3.3 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK60850.1 - 5.2e-13 49.1 44.7 9.9e-07 29.2 5.4 5.1 6 1 0 6 6 6 3 Human growth factor-like EGF EGF_2 PF07974.13 PIK60850.1 - 1.5e-11 44.5 39.4 5.2e-05 23.5 8.6 3.2 3 0 0 3 3 3 3 EGF-like domain EGF_3 PF12947.7 PIK60850.1 - 5.7e-05 23.2 33.3 0.059 13.6 6.6 3.8 2 1 1 3 3 3 3 EGF domain EGF_CA PF07645.15 PIK60850.1 - 0.0016 18.6 37.2 0.25 11.6 13.8 3.5 1 1 2 3 3 3 1 Calcium-binding EGF domain Laminin_EGF PF00053.24 PIK60850.1 - 0.0039 17.3 25.6 1.4 9.1 3.2 3.3 1 1 2 3 3 3 2 Laminin EGF domain cEGF PF12662.7 PIK60850.1 - 0.027 14.4 3.0 0.027 14.4 3.0 3.8 3 2 0 3 3 3 0 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK60850.1 - 0.75 10.1 32.0 1.4 9.2 5.0 3.9 2 2 1 3 3 3 0 Coagulation Factor Xa inhibitory site TAFA PF12020.8 PIK60850.1 - 2 8.9 13.3 10 6.6 1.1 3.1 1 1 1 2 2 2 0 TAFA family LRR_8 PF13855.6 PIK60851.1 - 7.3e-25 86.5 23.4 2.7e-15 55.9 6.8 2.9 2 1 1 3 3 3 2 Leucine rich repeat PIR PF00399.19 PIK60851.1 - 1.1e-17 63.0 25.9 0.54 9.9 0.0 10.5 10 0 0 10 10 10 8 Yeast PIR protein repeat LRR_4 PF12799.7 PIK60851.1 - 5.5e-16 58.4 41.7 7.2e-07 29.4 5.2 3.8 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK60851.1 - 6.5e-14 52.0 0.6 6.5e-14 52.0 0.6 2.4 3 0 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK60851.1 - 2.8e-05 23.7 6.6 0.009 15.5 3.4 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 PIK60851.1 - 0.0025 17.7 19.6 0.77 10.0 0.1 6.1 5 0 0 5 5 5 2 Leucine Rich repeat LRRNT PF01462.18 PIK60851.1 - 0.012 15.3 1.4 0.18 11.5 0.1 3.1 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 PIK60851.1 - 0.16 12.6 19.5 6.1 7.8 0.2 6.3 6 0 0 6 6 6 0 Leucine Rich Repeat EGF PF00008.27 PIK60852.1 - 9e-30 102.6 46.4 1e-08 35.3 5.7 4.4 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 PIK60852.1 - 2.2e-19 69.3 51.3 4e-06 27.2 3.1 5.2 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_2 PF07974.13 PIK60852.1 - 2.4e-12 47.0 55.6 0.00052 20.3 8.1 4.3 4 0 0 4 4 4 4 EGF-like domain EGF_CA PF07645.15 PIK60852.1 - 7.4e-08 32.5 47.5 0.00047 20.3 7.4 4.6 1 1 3 4 4 4 2 Calcium-binding EGF domain EGF_3 PF12947.7 PIK60852.1 - 5.4e-06 26.5 36.6 0.02 15.1 5.6 4.9 2 2 2 4 4 4 2 EGF domain cEGF PF12662.7 PIK60852.1 - 6.6e-06 26.0 34.5 0.016 15.1 0.9 5.0 4 2 0 4 4 4 4 Complement Clr-like EGF-like Laminin_EGF PF00053.24 PIK60852.1 - 1.9e-05 24.7 39.2 0.2 11.8 5.0 4.3 1 1 3 4 4 4 4 Laminin EGF domain FXa_inhibition PF14670.6 PIK60852.1 - 0.013 15.8 39.2 0.84 10.0 6.3 4.6 1 1 3 4 4 4 0 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK60852.1 - 0.074 13.1 1.6 0.074 13.1 1.6 4.6 4 1 0 4 4 4 0 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 PIK60852.1 - 0.68 10.3 34.5 4 7.8 6.2 4.7 3 1 1 4 4 4 0 Pvs28 EGF domain fn3 PF00041.21 PIK60853.1 - 1.6e-35 121.3 22.0 1.9e-07 31.3 0.1 6.2 6 0 0 6 6 6 5 Fibronectin type III domain DUF4998 PF16389.5 PIK60853.1 - 0.0058 16.2 2.4 1.2 8.7 0.1 3.2 3 1 0 3 3 3 2 Domain of unknown function Glyco_hydro_66 PF13199.6 PIK60853.1 - 0.0078 14.9 0.3 0.23 10.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 66 SUN PF03856.13 PIK60853.1 - 0.59 9.6 2.8 1.5 8.2 2.5 1.8 1 1 0 1 1 1 0 Beta-glucosidase (SUN family) HEAT_EZ PF13513.6 PIK60854.1 - 1.1e-30 105.6 5.8 5e-12 46.1 0.0 10.9 8 2 4 12 12 12 4 HEAT-like repeat HEAT PF02985.22 PIK60854.1 - 2.1e-29 99.0 11.9 0.0017 18.4 0.0 11.2 10 1 1 11 11 11 7 HEAT repeat HEAT_2 PF13646.6 PIK60854.1 - 9.7e-19 67.6 0.0 7.8e-05 23.0 0.0 6.3 4 2 3 7 7 7 5 HEAT repeats Arm PF00514.23 PIK60854.1 - 2.5e-13 49.6 4.7 0.017 15.2 0.0 7.3 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 PIK60854.1 - 2.3e-12 47.4 0.4 0.021 15.4 0.0 6.1 4 3 2 6 6 5 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK60854.1 - 2.5e-11 43.9 0.9 0.0018 18.4 0.3 5.1 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 PIK60854.1 - 3.1e-09 35.9 5.4 0.018 13.6 0.4 4.1 3 1 1 4 4 4 3 Adaptin N terminal region MMS19_C PF12460.8 PIK60854.1 - 1.9e-07 30.6 1.3 0.011 14.9 0.1 5.0 3 1 2 5 5 5 1 RNAPII transcription regulator C-terminal Xpo1 PF08389.12 PIK60854.1 - 7.1e-05 22.9 2.9 0.93 9.5 0.0 4.7 4 1 1 5 5 4 1 Exportin 1-like protein UNC45-central PF11701.8 PIK60854.1 - 0.00036 20.5 0.9 0.0024 17.8 0.1 2.7 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 PIK60854.1 - 0.00037 20.7 0.3 0.054 13.7 0.1 3.8 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 PIK60854.1 - 0.00057 19.5 0.8 10 5.6 0.0 4.7 3 2 2 5 5 5 0 Tti2 family Dopey_N PF04118.14 PIK60854.1 - 0.00064 18.9 0.5 0.0024 17.0 0.2 2.2 2 1 0 2 2 2 1 Dopey, N-terminal IFRD PF05004.13 PIK60854.1 - 0.0046 16.1 1.4 0.02 14.0 0.2 2.5 2 1 1 3 3 3 1 Interferon-related developmental regulator (IFRD) DUF3437 PF11919.8 PIK60854.1 - 0.0069 16.3 0.1 8.6 6.4 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) DUF3689 PF12463.8 PIK60854.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) TAFH PF07531.14 PIK60854.1 - 0.018 15.1 0.8 10 6.3 0.0 4.1 5 0 0 5 5 5 0 NHR1 homology to TAF CAS_CSE1 PF03378.15 PIK60854.1 - 0.053 12.0 0.6 0.53 8.7 0.0 2.4 2 0 0 2 2 2 0 CAS/CSE protein, C-terminus UME PF08064.13 PIK60854.1 - 0.13 12.2 3.3 43 4.1 0.3 4.8 4 2 0 4 4 4 0 UME (NUC010) domain RIX1 PF08167.12 PIK60854.1 - 0.35 10.6 5.5 46 3.7 0.1 4.9 4 2 1 5 5 5 0 rRNA processing/ribosome biogenesis Ras PF00071.22 PIK60855.1 - 2.3e-46 157.4 0.0 3e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK60855.1 - 5.3e-17 62.2 0.1 1.3e-16 60.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 PIK60855.1 - 1.8e-06 28.0 0.1 0.0092 15.9 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase Arf PF00025.21 PIK60855.1 - 2.7e-06 27.0 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MeaB PF03308.16 PIK60855.1 - 0.00011 21.3 0.0 0.33 9.9 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 PIK60855.1 - 0.0011 19.1 0.0 0.0018 18.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 PIK60855.1 - 0.0053 16.2 0.5 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF87 PF01935.17 PIK60855.1 - 0.027 14.6 0.0 0.65 10.0 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_16 PF13191.6 PIK60855.1 - 0.098 13.0 0.0 0.2 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 PIK60855.1 - 0.12 12.6 0.1 0.63 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 PIK60855.1 - 0.15 12.4 0.5 2 8.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain Patatin PF01734.22 PIK60856.1 - 3.5e-21 76.3 0.3 1.4e-20 74.3 0.3 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase Ank_5 PF13857.6 PIK60856.1 - 1.9e-15 56.7 2.1 1.1e-05 25.5 0.2 4.8 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK60856.1 - 2e-13 50.7 8.0 3.7e-07 30.6 1.7 3.8 2 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK60856.1 - 2e-11 44.2 0.6 4.5e-05 23.9 0.0 4.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK60856.1 - 5e-11 41.8 0.6 0.0062 16.9 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 PIK60856.1 - 5.8e-11 42.3 7.4 0.0012 19.2 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 PIK60857.1 - 7.8e-28 96.9 16.1 1.4e-07 32.0 1.7 4.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK60857.1 - 1e-19 70.3 2.6 1.1e-05 25.6 0.5 5.3 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK60857.1 - 5.8e-17 61.8 1.7 0.0005 20.6 0.0 5.9 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK60857.1 - 7e-17 59.8 2.7 0.00046 20.4 0.0 7.8 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 PIK60857.1 - 2.7e-15 56.0 9.6 0.011 16.2 0.0 6.0 5 1 0 5 5 5 5 Ankyrin repeat Clathrin PF00637.20 PIK60857.1 - 0.021 14.7 0.3 11 5.9 0.1 3.0 3 0 0 3 3 3 0 Region in Clathrin and VPS DUF2688 PF10892.8 PIK60858.1 - 0.092 12.2 1.3 0.14 11.6 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) DUF996 PF06195.13 PIK60858.1 - 0.63 10.3 12.4 0.077 13.3 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF996) DUF334 PF03904.13 PIK60863.1 - 0.083 12.4 0.8 0.8 9.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF334) NAD_synthase PF02540.17 PIK60867.1 - 0.12 11.5 0.2 0.14 11.2 0.2 1.1 1 0 0 1 1 1 0 NAD synthase RTP1_C1 PF10363.9 PIK60872.1 - 0.16 12.1 0.5 8.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 UCH PF00443.29 PIK60875.1 - 5.6e-29 101.4 0.0 1.4e-28 100.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK60875.1 - 1.1e-15 58.0 0.1 2.8e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Coat_F PF07875.12 PIK60875.1 - 0.08 13.2 1.0 0.4 10.9 0.0 2.6 3 0 0 3 3 3 0 Coat F domain rve PF00665.26 PIK60879.1 - 2.1e-21 76.3 0.0 4.1e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60879.1 - 2.6e-12 46.7 1.4 2.6e-12 46.7 1.4 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 PIK60879.1 - 2e-08 34.4 0.0 8.7e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK60879.1 - 0.019 14.7 0.0 0.049 13.4 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Spectrin PF00435.21 PIK60880.1 - 0.06 13.8 2.3 0.081 13.4 0.8 2.0 3 0 0 3 3 3 0 Spectrin repeat DUF4681 PF15732.5 PIK60880.1 - 0.076 13.3 0.2 0.17 12.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4681) Ribosomal_S5_C PF03719.15 PIK60880.1 - 0.19 11.2 0.5 0.69 9.4 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein S5, C-terminal domain PCRF PF03462.18 PIK60880.1 - 0.32 10.8 4.1 0.13 12.2 1.7 1.6 2 0 0 2 2 2 0 PCRF domain muHD PF10291.9 PIK60882.1 - 1.3e-32 113.3 0.9 1.7e-32 113.0 0.9 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF4467 PF14729.6 PIK60882.1 - 0.16 12.3 0.2 0.26 11.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) rve PF00665.26 PIK60883.1 - 5.2e-22 78.3 0.0 8.1e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK60883.1 - 3.8e-19 68.5 2.8 8e-19 67.5 2.8 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK60883.1 - 0.00044 20.0 0.2 0.00091 19.0 0.2 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK60883.1 - 0.0018 18.5 1.6 0.0054 16.9 1.6 1.9 1 0 0 1 1 1 1 H2C2 zinc finger TPP_enzyme_M_2 PF16582.5 PIK60883.1 - 0.056 13.1 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate Ketoacyl-synt_C PF02801.22 PIK60884.1 - 1.7e-36 124.8 0.2 3e-36 124.0 0.2 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 PIK60884.1 - 1.3e-24 87.2 0.1 4.9e-21 75.4 0.1 2.8 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 PIK60884.1 - 0.044 13.1 0.2 0.14 11.5 0.1 1.8 2 0 0 2 2 2 0 Thiolase, N-terminal domain zf-CCHC PF00098.23 PIK60885.1 - 1.1e-08 34.7 14.2 4.5e-05 23.3 0.7 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK60885.1 - 0.021 14.7 2.6 0.021 14.7 2.6 3.1 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK60885.1 - 0.63 10.0 11.6 1.7 8.7 2.6 2.7 1 1 1 2 2 2 0 Zinc knuckle IBR PF01485.21 PIK60885.1 - 1.4 9.2 15.1 3.5 7.9 15.1 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-CCHC_4 PF14392.6 PIK60885.1 - 2 8.2 12.8 0.51 10.1 0.3 3.1 1 1 2 3 3 3 0 Zinc knuckle CPSF100_C PF13299.6 PIK60885.1 - 2.4 8.3 10.8 3.5 7.8 10.8 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 PIK60885.1 - 5.1 5.8 7.2 6 5.6 7.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 PIK60885.1 - 6 5.0 12.3 7.2 4.8 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein XRN_M PF17846.1 PIK60885.1 - 9.2 5.1 9.3 12 4.7 9.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain V-set PF07686.17 PIK60886.1 - 1.8e-09 37.8 0.0 0.0023 18.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK60886.1 - 2.3e-07 31.3 0.0 0.0014 19.2 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK60886.1 - 3.7e-06 26.9 0.0 0.00048 20.1 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 PIK60886.1 - 3e-05 24.1 0.0 0.0002 21.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Aconitase_2_N PF06434.13 PIK60886.1 - 0.04 13.5 0.0 0.058 13.0 0.0 1.3 1 1 0 1 1 1 0 Aconitate hydratase 2 N-terminus Ig_2 PF13895.6 PIK60886.1 - 0.057 13.8 0.0 0.19 12.1 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 PIK60888.1 - 6.7e-09 36.2 0.0 1.1e-08 35.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 PIK60888.1 - 6.8e-08 32.7 0.1 1.3e-07 31.8 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK60888.1 - 4.3e-07 30.0 0.1 1.7e-06 28.1 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK60888.1 - 1.2e-06 28.5 0.1 4.2e-06 26.7 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_5 PF16681.5 PIK60888.1 - 0.0012 19.2 0.3 0.011 16.1 0.3 2.0 1 1 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 PIK60888.1 - 0.0016 18.8 0.0 0.0065 16.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain DUF1411 PF07199.11 PIK60888.1 - 0.024 14.3 0.1 0.029 14.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) Ig_3 PF13927.6 PIK60889.1 - 1.1e-10 41.9 0.2 1.7e-08 35.0 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK60889.1 - 2.7e-10 40.4 0.1 7.3e-10 39.0 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 PIK60889.1 - 5.3e-07 29.7 0.5 2.8e-06 27.4 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK60889.1 - 9.2e-07 28.9 0.2 2.3e-06 27.6 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_5 PF16681.5 PIK60889.1 - 0.00035 20.9 3.1 0.015 15.7 1.5 3.0 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 PIK60889.1 - 0.0063 16.8 0.1 0.087 13.2 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 PIK60889.1 - 0.0065 16.7 1.1 2.8 8.3 0.1 2.5 1 1 1 2 2 2 2 T-cell surface glycoprotein CD3 delta chain CD34_antigen PF06365.12 PIK60889.1 - 0.032 13.8 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family ECSCR PF15820.5 PIK60889.1 - 0.04 13.7 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Izumo-Ig PF16706.5 PIK60889.1 - 0.077 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain UreE_N PF02814.15 PIK60889.1 - 0.091 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 UreE urease accessory protein, N-terminal domain Death PF00531.22 PIK60890.1 - 0.00011 22.3 5.3 0.0012 18.9 0.3 2.9 3 1 0 3 3 3 2 Death domain DUF5410 PF17422.2 PIK60892.1 - 0.0069 15.7 0.4 0.0084 15.4 0.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5410) RICH PF05062.12 PIK60892.1 - 0.041 14.2 0.4 0.35 11.3 0.1 2.0 2 0 0 2 2 2 0 RICH domain Abp2 PF09441.10 PIK60892.1 - 0.05 13.7 0.3 0.062 13.4 0.3 1.2 1 0 0 1 1 1 0 ARS binding protein 2 Death PF00531.22 PIK60892.1 - 0.06 13.5 1.1 0.58 10.4 0.6 2.1 2 0 0 2 2 2 0 Death domain DUF3271 PF11675.8 PIK60892.1 - 0.071 12.4 0.1 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3271) Death PF00531.22 PIK60893.1 - 0.054 13.7 0.2 2.7 8.2 0.0 3.1 3 0 0 3 3 3 0 Death domain Ig_3 PF13927.6 PIK60894.1 - 1.3e-11 44.9 1.0 7.3e-09 36.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK60894.1 - 7.4e-09 35.7 0.5 2.1e-07 31.0 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK60894.1 - 1.5e-08 34.8 0.9 8.8e-08 32.3 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 PIK60894.1 - 5e-08 32.9 0.1 1.7e-07 31.2 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK60894.1 - 8.7e-06 26.0 0.8 0.031 14.6 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK60894.1 - 0.0001 22.3 0.4 0.00062 19.8 0.2 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK60894.1 - 0.012 16.0 0.9 0.29 11.6 0.3 2.9 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 PIK60894.1 - 0.058 13.8 0.9 1.6 9.2 0.4 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Cpn60_TCP1 PF00118.24 PIK60895.1 - 0.014 14.1 0.0 0.018 13.7 0.0 1.2 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family Ig_3 PF13927.6 PIK60896.1 - 2.6e-10 40.8 0.4 6.2e-08 33.1 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK60896.1 - 1.2e-09 38.3 0.1 2.8e-09 37.1 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK60896.1 - 1.1e-06 28.6 0.2 3e-06 27.2 0.2 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 PIK60896.1 - 7.3e-06 26.1 4.9 3.1e-05 24.1 0.1 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.5 PIK60896.1 - 0.00021 21.6 4.6 0.077 13.4 1.7 3.3 2 1 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Death PF00531.22 PIK60896.1 - 0.0012 19.0 2.2 0.047 13.8 0.2 2.9 3 0 0 3 3 3 1 Death domain Ig_2 PF13895.6 PIK60896.1 - 0.0067 16.7 1.4 0.076 13.4 0.0 2.6 1 1 1 2 2 2 1 Immunoglobulin domain ECSCR PF15820.5 PIK60896.1 - 0.007 16.2 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator CD34_antigen PF06365.12 PIK60896.1 - 0.014 15.0 0.0 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 CD34/Podocalyxin family Chordopox_A13L PF05961.11 PIK60896.1 - 0.058 13.6 0.4 0.54 10.5 0.1 2.5 2 0 0 2 2 2 0 Chordopoxvirus A13L protein CK2S PF15011.6 PIK60896.1 - 0.083 12.8 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 Casein Kinase 2 substrate EphA2_TM PF14575.6 PIK60896.1 - 0.1 13.5 0.2 0.33 11.9 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SLAC1 PF03595.17 PIK60896.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel SLATT_5 PF18160.1 PIK60896.1 - 0.48 9.7 2.4 31 3.8 0.0 3.0 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 Ig_4 PF16680.5 PIK60896.1 - 1.3 9.4 7.2 5.5 7.3 1.5 3.1 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Lectin_C PF00059.21 PIK60898.1 - 1.9e-18 67.2 0.4 2.3e-18 66.9 0.4 1.1 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 PIK60899.1 - 7.2e-08 33.1 0.0 8.3e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Lectin C-type domain Aminotran_1_2 PF00155.21 PIK60900.1 - 2.1e-33 116.0 0.0 2.8e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 PIK60900.1 - 0.021 13.5 0.0 0.041 12.6 0.0 1.4 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 PIK60900.1 - 0.025 13.9 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 PIK60900.1 - 0.031 13.2 0.0 0.053 12.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V WD40 PF00400.32 PIK60901.1 - 2.6e-26 91.3 20.7 0.0025 18.6 0.1 11.0 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK60901.1 - 1.7e-12 47.5 0.0 4.2e-05 23.8 0.0 5.6 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain GBP PF02263.19 PIK60902.1 - 6e-67 225.6 0.0 9.3e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 PIK60902.1 - 0.00015 21.3 0.1 0.00024 20.6 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 PIK60902.1 - 0.00016 22.0 0.0 0.0059 17.0 0.0 2.7 2 0 0 2 2 2 1 T-lymphoma invasion and metastasis CC-Ex domain G-patch PF01585.23 PIK60903.1 - 8.1e-07 28.8 1.0 1.8e-06 27.7 1.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK60903.1 - 0.0028 17.7 0.2 0.0096 16.0 0.2 1.9 1 0 0 1 1 1 1 G-patch domain Diphthami_syn_2 PF01902.17 PIK60904.1 - 8.3e-41 139.9 0.1 2.1e-40 138.6 0.1 1.6 1 0 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 PIK60904.1 - 8.2e-25 87.2 0.0 4e-13 49.4 0.0 3.5 3 0 0 3 3 3 3 Endoribonuclease L-PSP Pkinase PF00069.25 PIK60905.1 - 1.5e-41 142.6 0.0 1.7e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60905.1 - 3.9e-25 88.6 0.0 4.5e-25 88.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK60905.1 - 0.00035 20.0 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 PIK60905.1 - 0.0015 17.9 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 PIK60905.1 - 0.0054 15.7 0.1 0.0054 15.7 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 PIK60905.1 - 0.021 14.4 0.1 0.027 14.0 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 PIK60905.1 - 0.1 11.3 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 PIK60905.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 PIK60905.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 RIO1 family bZIP_1 PF00170.21 PIK60907.1 - 1.6e-08 34.6 14.4 1.6e-08 34.6 14.4 1.9 2 1 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 PIK60907.1 - 8.3e-08 32.6 14.5 8.3e-08 32.6 14.5 1.5 1 1 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 PIK60907.1 - 7.2e-06 26.0 13.4 7.2e-06 26.0 13.4 2.0 2 0 0 2 2 2 1 Basic region leucine zipper DUF2400 PF09674.10 PIK60907.1 - 0.11 12.5 1.5 0.13 12.2 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) SOBP PF15279.6 PIK60907.1 - 0.19 12.3 6.3 0.22 12.1 6.3 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3450 PF11932.8 PIK60907.1 - 0.21 10.8 8.0 0.29 10.4 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Macoilin PF09726.9 PIK60907.1 - 9.7 4.6 16.0 5.4 5.4 14.6 1.3 1 1 0 1 1 1 0 Macoilin family bZIP_2 PF07716.15 PIK60908.1 - 8.6e-06 25.7 18.2 8.6e-06 25.7 18.2 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 PIK60908.1 - 0.00029 20.9 21.4 0.00078 19.5 21.4 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 PIK60908.1 - 0.099 13.2 10.9 0.35 11.4 10.9 1.9 1 0 0 1 1 1 0 bZIP Maf transcription factor Trm112p PF03966.16 PIK60909.1 - 2.1e-08 34.6 0.0 2.7e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein Pkinase PF00069.25 PIK60910.1 - 3.7e-20 72.4 0.0 4.7e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60910.1 - 9.2e-14 51.3 0.2 1.1e-13 51.1 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 PIK60910.1 - 0.0018 18.2 0.0 0.95 9.3 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 PIK60910.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FDF PF09532.10 PIK60911.1 - 3.5 8.5 9.2 0.33 11.9 4.0 1.9 2 0 0 2 2 2 0 FDF domain RrnaAD PF00398.20 PIK60914.1 - 1.1e-12 47.6 0.0 2.7e-12 46.4 0.0 1.6 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF2838 PF10998.8 PIK60914.1 - 0.12 12.6 0.4 0.29 11.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) RNase_PH PF01138.21 PIK60915.1 - 5.2e-23 82.0 0.6 5.2e-23 82.0 0.6 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK60915.1 - 1.2e-05 25.3 0.2 3.8e-05 23.6 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Glyco_hydro_1 PF00232.18 PIK60916.1 - 1.1e-50 172.4 0.3 1.3e-50 172.1 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cadherin_5 PF17892.1 PIK60916.1 - 0.098 12.6 0.3 0.14 12.1 0.3 1.2 1 0 0 1 1 1 0 Cadherin-like domain AMP-binding PF00501.28 PIK60917.1 - 1.1e-25 90.2 0.2 1.5e-25 89.7 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK60917.1 - 0.00035 21.5 0.0 0.00073 20.5 0.0 1.5 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK60918.1 - 5.9e-24 84.4 0.0 6.5e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme EF-hand_7 PF13499.6 PIK60919.1 - 7.1e-10 39.2 1.6 7.1e-10 39.2 1.6 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK60919.1 - 1.5e-09 36.7 6.7 6.5e-05 22.2 1.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 PIK60919.1 - 2.1e-07 30.3 6.8 0.00034 20.3 0.2 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 PIK60919.1 - 1.9e-06 27.6 7.2 0.0026 17.6 0.4 3.5 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK60919.1 - 0.028 14.8 0.1 0.05 13.9 0.1 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 PIK60919.1 - 0.12 12.0 5.6 2.5 7.7 0.8 2.7 2 0 0 2 2 2 0 EF hand Homez PF11569.8 PIK60919.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez EF-hand_7 PF13499.6 PIK60920.1 - 5.7e-15 55.5 0.1 1.3e-09 38.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 PIK60920.1 - 1.3e-11 43.2 2.0 0.00027 20.3 0.1 3.5 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 PIK60920.1 - 8.8e-11 40.8 0.6 0.00053 19.7 0.1 4.2 3 1 1 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 PIK60920.1 - 0.00046 20.0 1.5 0.012 15.4 0.7 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 PIK60920.1 - 0.078 13.3 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain PUF PF00806.19 PIK60920.1 - 0.094 12.4 0.0 0.33 10.7 0.0 1.9 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Sel_put PF04328.13 PIK60921.1 - 0.011 15.7 0.3 0.029 14.4 0.3 1.6 1 0 0 1 1 1 0 Selenoprotein, putative WWE PF02825.20 PIK60921.1 - 0.011 16.3 0.6 0.011 16.3 0.6 2.0 2 0 0 2 2 2 0 WWE domain TMEM72 PF16054.5 PIK60922.1 - 1.6e-10 41.0 2.0 1.9e-10 40.7 2.0 1.0 1 0 0 1 1 1 1 Transmembrane protein family 72 Cg6151-P PF10233.9 PIK60922.1 - 9.1e-07 29.2 5.8 1.2e-06 28.8 5.8 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF565 PF04483.12 PIK60922.1 - 0.0063 17.0 0.4 0.013 16.0 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF565) Phage_holin_3_6 PF07332.11 PIK60922.1 - 0.95 9.5 6.8 12 6.0 6.8 2.0 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III COPI_assoc PF08507.10 PIK60922.1 - 1 9.4 7.5 1.8 8.7 7.5 1.4 1 1 0 1 1 1 0 COPI associated protein CD20 PF04103.15 PIK60922.1 - 1.1 9.4 10.3 34 4.5 10.4 2.3 1 1 0 1 1 1 0 CD20-like family DUF308 PF03729.13 PIK60922.1 - 1.4 9.3 14.7 0.69 10.3 2.3 2.7 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) DUF1206 PF06724.11 PIK60922.1 - 7.6 6.7 7.7 6.8 6.8 1.8 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1206) DUF1943 PF09172.11 PIK60923.1 - 2e-12 47.0 0.1 1.3e-05 24.6 0.0 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF1943) OMP_b-brl PF13505.6 PIK60923.1 - 2.5e-07 31.0 1.2 1.6e-05 25.1 1.2 2.3 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain OMP_b-brl_2 PF13568.6 PIK60923.1 - 1.4e-05 25.2 0.1 0.79 9.7 0.0 3.9 1 1 1 2 2 2 2 Outer membrane protein beta-barrel domain MspA PF09203.11 PIK60923.1 - 1.6e-05 24.9 0.3 0.045 13.6 0.3 2.9 1 1 0 1 1 1 1 MspA OMP_b-brl_3 PF14905.6 PIK60923.1 - 2.9e-05 23.2 0.2 0.045 12.7 0.1 2.4 1 1 1 2 2 2 2 Outer membrane protein beta-barrel family DUF2715 PF10895.8 PIK60923.1 - 0.00025 20.7 6.7 1 9.0 3.3 3.9 1 1 1 2 2 2 2 Domain of unknown function (DUF2715) PorP_SprF PF11751.8 PIK60923.1 - 0.0023 17.5 0.7 0.03 13.8 0.7 2.3 1 1 0 1 1 1 1 Type IX secretion system membrane protein PorP/SprF DUF481 PF04338.12 PIK60923.1 - 0.035 14.1 0.0 1.9 8.5 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF481 DUF3194 PF11419.8 PIK60923.1 - 0.044 14.1 52.9 7 7.1 0.3 7.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3194) OmpW PF03922.14 PIK60923.1 - 0.083 12.8 18.6 1.6 8.6 0.8 4.3 1 1 3 4 4 4 0 OmpW family Guanylate_kin PF00625.21 PIK60924.1 - 3.1e-20 72.6 0.1 3.1e-13 49.8 0.0 2.1 2 0 0 2 2 2 2 Guanylate kinase VGCC_beta4Aa_N PF12052.8 PIK60925.1 - 2.3e-19 69.2 5.4 4e-19 68.4 5.4 1.4 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal NTR2 PF15458.6 PIK60925.1 - 0.059 12.9 0.2 0.064 12.8 0.2 1.1 1 0 0 1 1 1 0 Nineteen complex-related protein 2 EF_TS PF00889.19 PIK60926.1 - 3.5e-24 85.6 0.0 5.9e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor TS Guanylate_kin PF00625.21 PIK60927.1 - 9.3e-38 129.7 1.6 1.3e-37 129.3 1.6 1.1 1 0 0 1 1 1 1 Guanylate kinase T3SS_needle_E PF08988.10 PIK60927.1 - 0.0014 18.7 0.2 0.0067 16.6 0.3 1.9 2 0 0 2 2 2 1 Type III secretion system, cytoplasmic E component of needle Shikimate_DH PF01488.20 PIK60927.1 - 0.004 17.2 0.2 0.0094 16.0 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase PPP1R35_C PF15503.6 PIK60927.1 - 0.077 12.8 0.4 0.11 12.3 0.4 1.2 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus HEAT PF02985.22 PIK60928.1 - 9.2e-15 53.5 14.4 3.6e-05 23.6 0.1 9.7 10 0 0 10 10 9 2 HEAT repeat HEAT_EZ PF13513.6 PIK60928.1 - 2.1e-13 50.5 4.1 1.6e-08 34.9 0.1 7.3 9 0 0 9 9 8 1 HEAT-like repeat IBN_N PF03810.19 PIK60928.1 - 1.5e-09 37.6 0.1 5.3e-08 32.7 0.0 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 PIK60928.1 - 3.8e-08 33.6 8.9 0.012 16.0 0.2 7.4 6 2 2 8 8 8 1 HEAT repeats Arm PF00514.23 PIK60928.1 - 0.00062 19.7 0.1 0.00062 19.7 0.1 5.8 8 0 0 8 8 7 1 Armadillo/beta-catenin-like repeat UME PF08064.13 PIK60928.1 - 0.0018 18.2 7.8 0.91 9.5 0.5 4.7 4 2 0 5 5 5 2 UME (NUC010) domain RIX1 PF08167.12 PIK60928.1 - 0.011 15.5 1.1 2.5 7.8 0.0 4.0 3 2 1 4 4 4 0 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 PIK60928.1 - 0.014 16.0 4.2 0.32 11.6 0.8 4.2 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 PIK60928.1 - 0.02 14.4 3.7 2.8 7.5 0.1 4.6 3 1 2 5 5 5 0 CLASP N terminal Xpo1 PF08389.12 PIK60928.1 - 0.029 14.4 11.5 0.84 9.7 0.3 4.7 3 2 1 4 4 4 0 Exportin 1-like protein GCFC PF07842.12 PIK60928.1 - 0.044 13.4 0.4 0.13 11.8 0.3 1.8 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein V-ATPase_H_C PF11698.8 PIK60928.1 - 0.9 9.7 6.8 0.61 10.2 1.3 3.4 3 0 0 3 3 3 0 V-ATPase subunit H zf-C2H2 PF00096.26 PIK60929.1 - 1.1e-27 95.0 58.9 3.7e-06 27.1 0.4 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK60929.1 - 4.6e-23 80.5 50.1 1.6e-07 31.4 0.3 7.4 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK60929.1 - 3.8e-20 70.8 54.9 0.0002 21.9 1.5 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK60929.1 - 9e-05 22.4 49.7 0.0094 15.9 0.6 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-Di19 PF05605.12 PIK60929.1 - 0.0001 22.5 42.2 0.019 15.3 0.3 5.0 1 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 PIK60929.1 - 0.0051 16.6 2.7 6.2 6.7 0.2 3.5 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-met PF12874.7 PIK60929.1 - 0.057 13.8 0.7 0.057 13.8 0.7 6.5 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Zn-C2H2_12 PF18112.1 PIK60929.1 - 0.084 13.4 0.2 0.084 13.4 0.2 4.8 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain UBZ_FAAP20 PF15750.5 PIK60929.1 - 0.084 12.8 6.6 8.8 6.4 0.2 3.9 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-C2H2_jaz PF12171.8 PIK60929.1 - 0.12 12.7 0.3 0.12 12.7 0.3 6.5 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 PIK60929.1 - 0.31 11.2 30.2 4.2 7.6 4.7 5.4 3 2 2 5 5 4 0 Zinc ribbon domain GAGA PF09237.11 PIK60929.1 - 2.1 8.2 27.5 6.1 6.7 0.1 5.9 2 2 4 6 6 6 0 GAGA factor CpXC PF14353.6 PIK60929.1 - 3.4 7.7 26.5 2.2 8.4 2.2 5.5 1 1 4 5 5 4 0 CpXC protein zf_UBZ PF18439.1 PIK60929.1 - 5.8 6.6 28.4 1.3 8.7 0.1 6.1 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger CRAL_TRIO PF00650.20 PIK60930.1 - 1.7e-05 24.6 0.0 0.14 11.9 0.0 2.7 2 0 0 2 2 2 2 CRAL/TRIO domain Spectrin PF00435.21 PIK60930.1 - 0.00025 21.5 14.3 0.0042 17.5 0.0 4.7 4 2 0 4 4 4 2 Spectrin repeat CRAL_TRIO_2 PF13716.6 PIK60930.1 - 0.011 15.9 0.0 0.04 14.1 0.0 1.9 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain Spectrin PF00435.21 PIK60931.1 - 1.1e-19 70.9 24.8 9.7e-08 32.4 2.6 4.4 2 1 1 3 3 3 3 Spectrin repeat TEX12 PF15219.6 PIK60931.1 - 0.016 15.5 1.3 8.3 6.8 0.1 3.5 3 0 0 3 3 3 0 Testis-expressed 12 Sec34 PF04136.15 PIK60931.1 - 0.023 14.6 13.2 0.57 10.0 2.9 4.1 2 1 0 3 3 3 0 Sec34-like family ABC_tran_CTD PF16326.5 PIK60931.1 - 0.1 12.9 0.4 0.1 12.9 0.4 4.7 3 1 1 4 4 4 0 ABC transporter C-terminal domain Glyco_trans_1_4 PF13692.6 PIK60931.1 - 0.16 12.4 0.3 1.7 9.1 0.0 2.6 2 1 1 3 3 3 0 Glycosyl transferases group 1 Med28 PF11594.8 PIK60931.1 - 0.22 11.6 11.3 1.2 9.2 2.1 3.5 3 1 0 3 3 3 0 Mediator complex subunit 28 FCD PF07729.12 PIK60931.1 - 0.58 10.6 9.5 1.8 9.0 0.4 3.8 3 1 2 5 5 5 0 FCD domain DUF948 PF06103.11 PIK60931.1 - 0.58 10.4 12.1 10 6.5 0.5 4.8 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) GIT1_C PF12205.8 PIK60931.1 - 1.2 9.2 6.6 0.21 11.7 0.6 2.6 3 1 0 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF1798 PF08807.10 PIK60931.1 - 1.6 8.9 5.4 1.1 9.4 0.3 3.1 2 1 1 3 3 3 0 Bacterial domain of unknown function (DUF1798) Lipoprotein_6 PF01441.19 PIK60931.1 - 3.7 7.5 9.5 0.84 9.6 2.1 3.1 2 2 2 4 4 4 0 Lipoprotein PspA_IM30 PF04012.12 PIK60931.1 - 6.3 6.3 20.8 0.66 9.5 5.4 3.2 2 1 0 3 3 3 0 PspA/IM30 family I-set PF07679.16 PIK60933.1 - 8.9e-58 192.4 0.0 3.1e-19 68.8 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60933.1 - 5.5e-36 123.0 0.0 4.6e-13 49.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK60933.1 - 4.5e-25 87.7 0.0 4.3e-08 33.2 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK60933.1 - 4.3e-23 81.4 0.0 5.4e-08 33.1 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK60933.1 - 1.1e-08 35.1 1.0 0.79 9.9 0.1 5.7 3 3 1 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60933.1 - 1e-07 31.9 0.1 0.057 13.5 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK60933.1 - 7e-06 26.4 0.5 0.38 11.2 0.0 4.1 3 2 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 PIK60933.1 - 2.5e-05 24.4 0.7 0.011 15.9 0.0 3.2 3 2 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK60933.1 - 0.00025 21.4 0.1 0.72 10.3 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 PIK60933.1 - 0.00054 19.5 0.0 0.17 11.5 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 PIK60933.1 - 0.0099 15.9 0.2 5 7.2 0.0 3.1 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_3 PF13927.6 PIK60934.1 - 5.2e-06 27.0 0.1 4.4e-05 24.0 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60934.1 - 3.1e-05 24.2 0.0 6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK60934.1 - 9.9e-05 22.3 0.0 0.00023 21.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK60934.1 - 0.03 14.4 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK60934.1 - 0.13 12.5 0.0 0.52 10.5 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK60935.1 - 1.3e-139 454.6 0.0 1.9e-18 66.3 0.0 9.0 9 0 0 9 9 9 9 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60935.1 - 2.4e-121 396.5 4.8 5.2e-15 55.8 0.1 9.2 8 1 1 9 9 9 8 Immunoglobulin domain Ig_2 PF13895.6 PIK60935.1 - 5.5e-88 289.4 8.3 6.1e-12 45.7 0.1 9.1 7 1 2 9 9 9 9 Immunoglobulin domain ig PF00047.25 PIK60935.1 - 1.4e-68 227.1 0.1 5.4e-09 36.1 0.0 9.2 8 1 1 9 9 9 8 Immunoglobulin domain V-set PF07686.17 PIK60935.1 - 1.2e-33 115.5 11.4 0.0037 17.4 0.0 13.7 9 6 0 9 9 9 7 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60935.1 - 1.3e-31 108.5 11.1 0.0019 18.2 0.0 8.7 8 1 0 8 8 8 8 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 PIK60935.1 - 4.3e-20 71.5 0.0 0.51 10.4 0.0 8.2 6 1 2 8 8 8 6 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 PIK60935.1 - 2.7e-15 56.4 0.0 0.4 11.0 0.0 8.5 9 1 0 9 9 9 3 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 PIK60935.1 - 1.9e-13 50.6 0.0 1.2 9.6 0.0 8.2 8 1 0 8 8 8 2 Immunoglobulin C1-set domain C2-set PF05790.15 PIK60935.1 - 4.3e-10 39.7 0.8 1.5 9.0 0.0 7.5 7 1 1 8 8 8 2 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 PIK60935.1 - 8e-07 29.0 0.0 46 4.2 0.0 6.6 7 0 0 7 7 7 0 Izumo-like Immunoglobulin domain CBM_5_12 PF02839.14 PIK60935.1 - 4.4e-05 23.8 9.3 22 5.9 0.1 6.5 5 0 0 5 5 5 0 Carbohydrate binding domain Receptor_2B4 PF11465.8 PIK60935.1 - 5.5e-05 23.3 0.0 65 3.8 0.0 6.2 7 0 0 7 7 7 0 Natural killer cell receptor 2B4 Ig_6 PF18452.1 PIK60935.1 - 0.00012 21.5 0.0 11 5.7 0.0 5.7 7 0 0 7 7 7 1 Immunoglobulin domain ICAM_N PF03921.14 PIK60935.1 - 0.0026 17.4 0.0 85 2.9 0.0 4.3 4 0 0 4 4 4 0 Intercellular adhesion molecule (ICAM), N-terminal domain I-set PF07679.16 PIK60936.1 - 5.7e-165 535.9 0.0 5.3e-18 64.9 0.0 10.0 10 0 0 10 10 10 10 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60936.1 - 2.4e-141 460.6 3.1 1.4e-15 57.7 0.1 10.2 10 0 0 10 10 10 10 Immunoglobulin domain Ig_2 PF13895.6 PIK60936.1 - 2e-108 354.9 11.9 2e-13 50.5 0.0 10.1 9 1 1 10 10 10 10 Immunoglobulin domain ig PF00047.25 PIK60936.1 - 2.5e-88 290.4 0.0 5.9e-11 42.4 0.0 10.2 10 0 0 10 10 10 10 Immunoglobulin domain V-set PF07686.17 PIK60936.1 - 3.4e-41 139.8 15.1 0.00019 21.6 0.1 15.2 10 6 1 11 11 11 9 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60936.1 - 5.2e-32 109.8 10.9 0.0084 16.2 0.0 9.6 9 1 0 9 9 9 8 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 PIK60936.1 - 1.6e-21 76.4 0.2 0.096 13.0 0.0 10.5 10 2 0 10 10 10 4 T-cell surface glycoprotein CD3 delta chain C2-set PF05790.15 PIK60936.1 - 1.3e-20 73.3 0.7 0.059 13.6 0.0 9.6 9 0 0 9 9 9 3 Immunoglobulin C2-set domain C1-set PF07654.15 PIK60936.1 - 5.2e-19 68.4 0.0 0.41 11.1 0.0 9.7 9 2 0 9 9 9 5 Immunoglobulin C1-set domain Ig_5 PF16681.5 PIK60936.1 - 1.9e-13 50.6 0.0 1.7 9.1 0.0 9.4 10 0 0 10 10 9 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK60936.1 - 1.9e-12 47.1 0.0 2.6 8.2 0.0 9.6 10 0 0 10 10 10 1 Izumo-like Immunoglobulin domain BiPBP_C PF06832.12 PIK60936.1 - 7.4e-12 45.2 0.0 1.2 9.2 0.0 8.0 9 0 0 9 9 9 2 Penicillin-Binding Protein C-terminus Family Ig_C17orf99 PF17736.1 PIK60936.1 - 4.6e-10 39.4 1.0 15 5.7 0.0 8.8 9 0 0 9 9 9 0 C17orf99 Ig domain Ig_6 PF18452.1 PIK60936.1 - 8.3e-08 31.7 0.1 17 5.1 0.0 7.8 9 0 0 9 9 9 0 Immunoglobulin domain SAG PF04092.13 PIK60936.1 - 3.6e-06 27.8 0.5 45 4.8 0.0 7.0 7 0 0 7 7 7 0 SRS domain Receptor_2B4 PF11465.8 PIK60936.1 - 5.8e-05 23.3 0.0 11 6.2 0.0 6.9 9 0 0 9 9 9 0 Natural killer cell receptor 2B4 ICAM_N PF03921.14 PIK60936.1 - 7.4e-05 22.4 3.7 36 4.1 0.0 7.2 8 0 0 8 8 8 0 Intercellular adhesion molecule (ICAM), N-terminal domain CBM_5_12 PF02839.14 PIK60936.1 - 0.00092 19.7 27.3 34 5.3 0.2 9.5 10 0 0 10 10 9 0 Carbohydrate binding domain I-set PF07679.16 PIK60937.1 - 6.4e-296 955.6 0.0 8.2e-21 73.9 0.0 16.1 16 0 0 16 16 16 16 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60937.1 - 1.6e-206 669.5 18.3 4.2e-15 56.1 0.1 16.3 16 0 0 16 16 16 16 Immunoglobulin domain Ig_2 PF13895.6 PIK60937.1 - 5e-135 440.1 10.0 1.5e-13 50.9 0.0 16.2 16 0 0 16 16 16 15 Immunoglobulin domain ig PF00047.25 PIK60937.1 - 2.1e-103 338.7 0.1 1.6e-08 34.6 0.0 16.1 16 0 0 16 16 16 15 Immunoglobulin domain V-set PF07686.17 PIK60937.1 - 4.3e-59 197.4 19.9 2.1e-06 27.8 0.1 22.7 16 9 0 16 16 16 12 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60937.1 - 4.6e-34 116.3 19.7 0.02 14.9 0.0 16.0 16 1 0 16 16 16 6 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 PIK60937.1 - 1.4e-18 66.7 0.2 0.35 11.0 0.0 13.9 13 2 2 15 15 15 1 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 PIK60937.1 - 7.6e-18 64.5 9.2 0.27 11.5 0.0 11.6 13 0 0 13 13 11 4 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK60937.1 - 1.4e-16 60.3 1.4 1.1 9.4 0.0 11.5 12 0 0 12 12 12 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 PIK60937.1 - 2.2e-13 50.4 0.0 1 9.6 0.0 11.3 14 0 0 14 14 14 1 Natural killer cell receptor 2B4 Ig_6 PF18452.1 PIK60937.1 - 6.1e-09 35.3 1.7 0.25 10.9 0.0 8.2 10 0 0 10 10 10 2 Immunoglobulin domain C1-set PF07654.15 PIK60937.1 - 1e-08 35.4 4.8 9.2 6.7 0.0 10.1 12 0 0 12 12 11 1 Immunoglobulin C1-set domain C2-set PF05790.15 PIK60937.1 - 1.7e-05 24.9 8.7 0.15 12.3 0.0 7.5 9 0 0 9 9 8 1 Immunoglobulin C2-set domain Cupredoxin_1 PF13473.6 PIK60937.1 - 0.00058 19.9 4.5 6.8 6.9 0.1 5.0 4 0 0 4 4 4 1 Cupredoxin-like domain DUF11 PF01345.18 PIK60937.1 - 0.00073 19.8 0.2 8.3 6.8 0.0 6.1 7 1 0 7 7 5 1 Domain of unknown function DUF11 MG2 PF01835.19 PIK60937.1 - 0.0017 18.8 1.2 49 4.5 0.0 5.8 6 1 0 6 6 4 0 MG2 domain bMG6 PF17962.1 PIK60937.1 - 0.0091 16.1 1.2 67 3.7 0.1 5.9 6 0 0 6 6 5 0 Bacterial macroglobulin domain 6 TOBE_2 PF08402.10 PIK60937.1 - 0.056 13.6 0.1 54 4.0 0.0 4.6 5 0 0 5 5 5 0 TOBE domain AglB_L1 PF18079.1 PIK60937.1 - 0.87 9.9 5.3 62 4.0 0.0 6.3 7 0 0 7 7 6 0 Archaeal glycosylation protein B long peripheral domain I-set PF07679.16 PIK60938.1 - 8.7e-76 250.1 1.5 5.3e-25 87.3 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60938.1 - 1.4e-46 157.0 0.2 2.1e-15 57.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK60938.1 - 8.2e-29 99.8 0.2 8.2e-10 38.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK60938.1 - 8.1e-26 90.0 0.2 3.4e-09 36.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK60938.1 - 3.4e-12 46.5 1.6 0.055 13.6 0.0 5.5 3 3 3 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60938.1 - 8.4e-10 38.6 0.3 0.026 14.6 0.0 3.8 3 1 0 3 3 3 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK60938.1 - 0.00011 22.5 0.2 3.9 7.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 PIK60938.1 - 0.00047 20.1 0.1 0.37 10.8 0.0 3.2 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Receptor_2B4 PF11465.8 PIK60938.1 - 0.0005 20.2 0.0 1.2 9.4 0.0 3.3 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 PIK60938.1 - 0.00081 19.4 0.0 7.2 6.7 0.0 3.9 4 0 0 4 4 4 2 C17orf99 Ig domain Ig_4 PF16680.5 PIK60938.1 - 0.0011 19.2 0.7 4 7.8 0.2 3.7 3 2 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 PIK60938.1 - 0.0032 17.5 0.3 15 5.8 0.1 3.6 3 1 1 4 4 4 0 Izumo-like Immunoglobulin domain Herpes_gE PF02480.16 PIK60938.1 - 0.028 13.2 1.7 2.8 6.6 0.2 2.9 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E I-set PF07679.16 PIK60939.1 - 2e-50 168.8 0.0 3.9e-19 68.5 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60939.1 - 1.1e-32 112.4 0.0 1.4e-12 48.0 0.0 4.5 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 PIK60939.1 - 3.4e-22 78.6 0.0 2.3e-09 37.4 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK60939.1 - 8.3e-18 64.4 0.0 6e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 PIK60939.1 - 7.4e-09 35.8 0.2 0.72 10.1 0.0 5.7 4 2 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60939.1 - 1.9e-05 24.6 0.0 0.063 13.4 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK60939.1 - 0.0039 17.5 0.0 2.4 8.6 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin C1-set domain I-set PF07679.16 PIK60940.1 - 4.5e-88 289.5 0.0 4e-21 74.9 0.0 5.1 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60940.1 - 7.7e-58 193.1 0.4 2.7e-13 50.3 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 PIK60940.1 - 3.9e-39 132.9 0.2 7e-12 45.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 PIK60940.1 - 3.9e-34 116.7 0.1 5.7e-12 45.6 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 PIK60940.1 - 2.2e-17 63.2 2.2 0.00073 19.7 0.1 6.9 5 2 0 5 5 5 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60940.1 - 8.8e-13 48.1 0.1 0.028 14.5 0.0 4.7 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 PIK60940.1 - 0.0056 16.7 0.2 15 5.7 0.0 4.4 5 0 0 5 5 5 1 C17orf99 Ig domain Izumo-Ig PF16706.5 PIK60940.1 - 0.01 15.9 0.2 0.38 10.8 0.0 3.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain C2-set PF05790.15 PIK60940.1 - 0.059 13.6 0.0 29 4.9 0.0 3.6 3 0 0 3 3 3 0 Immunoglobulin C2-set domain I-set PF07679.16 PIK60941.1 - 9.6e-80 262.8 0.0 4.8e-23 81.0 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60941.1 - 2.5e-52 175.4 3.2 1.8e-16 60.5 0.1 5.9 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 PIK60941.1 - 1.4e-34 118.3 1.5 3.6e-13 49.6 0.2 4.8 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK60941.1 - 4.4e-28 97.3 1.1 2.6e-09 37.1 0.0 5.7 6 0 0 6 6 6 4 Immunoglobulin domain V-set PF07686.17 PIK60941.1 - 1.4e-19 70.2 0.4 0.0067 16.6 0.0 6.3 5 1 1 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60941.1 - 8.8e-13 48.1 3.1 0.032 14.3 0.0 5.5 5 0 0 5 5 5 4 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 PIK60941.1 - 0.0011 18.9 0.0 2.8 8.0 0.0 4.5 4 0 0 4 4 4 1 Penicillin-Binding Protein C-terminus Family Ig_6 PF18452.1 PIK60941.1 - 0.019 14.5 0.1 0.24 11.0 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Ig_C17orf99 PF17736.1 PIK60941.1 - 0.1 12.7 0.1 27 4.9 0.0 3.9 3 0 0 3 3 3 0 C17orf99 Ig domain I-set PF07679.16 PIK60942.1 - 9e-39 131.4 0.7 3.3e-18 65.5 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60942.1 - 6.7e-25 87.5 0.0 3.6e-12 46.7 0.1 3.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK60942.1 - 5.9e-12 45.7 0.0 1.2e-06 28.7 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK60942.1 - 7.3e-12 45.3 0.1 4.5e-07 30.0 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK60942.1 - 6e-06 26.2 0.0 0.23 11.6 0.0 3.0 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK60943.1 - 1.4e-19 69.9 0.9 7e-19 67.7 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60943.1 - 2e-10 41.1 0.0 6.8e-10 39.4 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60943.1 - 0.002 18.4 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK60943.1 - 0.012 15.6 0.0 0.047 13.8 0.0 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK60943.1 - 0.02 15.0 0.0 0.049 13.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK60944.1 - 9.4e-20 70.5 0.1 4.9e-19 68.2 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60944.1 - 1.1e-10 42.0 0.0 4.9e-10 39.9 0.0 2.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60944.1 - 0.0012 19.1 0.0 0.003 17.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK60944.1 - 0.0079 16.2 0.0 0.034 14.2 0.0 2.1 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK60944.1 - 0.012 15.8 0.0 0.036 14.3 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK60945.1 - 3.7e-38 129.5 0.2 6.4e-21 74.2 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60945.1 - 2.4e-24 85.7 0.0 1.5e-11 44.8 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK60945.1 - 4.4e-11 42.8 0.1 0.00035 20.7 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK60945.1 - 5.4e-09 36.3 0.0 0.0011 19.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK60945.1 - 3.4e-08 33.5 0.0 0.019 15.0 0.0 3.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK60945.1 - 0.0018 18.6 2.8 3.1 8.2 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin C1-set domain Phage_endo_I PF05367.11 PIK60945.1 - 0.076 12.6 0.1 17 5.0 0.0 2.3 2 0 0 2 2 2 0 Phage endonuclease I DUF406 PF04175.12 PIK60945.1 - 0.39 11.2 7.5 4.3 7.9 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF406) I-set PF07679.16 PIK60946.1 - 1.2e-21 76.5 0.0 2.9e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60946.1 - 2.5e-12 47.2 0.0 6.7e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK60946.1 - 7.6e-05 22.8 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 PIK60946.1 - 0.00026 21.3 0.0 0.0005 20.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK60946.1 - 0.0038 17.3 0.0 0.0095 16.0 0.0 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 PIK60947.1 - 7.4e-09 35.6 0.0 2.4e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60947.1 - 2.5e-08 34.4 0.0 9.4e-08 32.6 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK60947.1 - 0.00095 19.3 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK60947.1 - 0.017 15.2 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Big_4 PF07532.11 PIK60947.1 - 0.33 10.7 11.6 12 5.7 2.2 4.3 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 4) CDC48_2 PF02933.17 PIK60947.1 - 2.9 7.7 10.2 9.4 6.1 1.5 2.8 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 FixG_C PF11614.8 PIK60948.1 - 3.2 8.0 9.6 2 8.7 5.7 2.1 1 1 1 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF4330 PF14221.6 PIK60948.1 - 4.2 7.6 7.2 16 5.7 7.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4330) I-set PF07679.16 PIK60949.1 - 1e-17 64.0 0.0 2.6e-17 62.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60949.1 - 4e-10 40.1 0.0 1.1e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK60949.1 - 0.0053 16.8 0.0 0.012 15.6 0.0 1.8 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK60949.1 - 0.0059 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF3338 PF11819.8 PIK60949.1 - 0.068 13.1 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) ig PF00047.25 PIK60949.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 PIK60950.1 - 3.1e-33 113.7 0.1 1.8e-17 63.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60950.1 - 6.8e-25 87.5 0.0 3.4e-12 46.8 0.0 3.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 PIK60950.1 - 3.8e-13 49.4 0.0 5.2e-07 29.8 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK60950.1 - 1.6e-12 47.6 0.0 3.6e-07 30.4 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK60950.1 - 0.0015 18.7 0.0 4.4 7.5 0.1 3.6 2 1 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60950.1 - 0.002 18.1 0.0 1 9.5 0.0 3.1 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain GET2 PF08690.10 PIK60951.1 - 1.3 8.6 3.6 1.4 8.6 3.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Myc-LZ PF02344.15 PIK60952.1 - 2.8 8.1 6.7 8 6.6 0.4 2.6 2 0 0 2 2 2 0 Myc leucine zipper domain I-set PF07679.16 PIK60953.1 - 1.8e-97 319.6 1.7 5.9e-21 74.3 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60953.1 - 9.1e-58 192.8 3.5 1.4e-11 44.9 0.0 7.7 7 0 0 7 7 7 5 Immunoglobulin domain Ig_2 PF13895.6 PIK60953.1 - 6e-34 116.2 0.0 4.5e-09 36.5 0.0 6.1 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.25 PIK60953.1 - 4.7e-32 110.0 0.0 4.6e-07 29.9 0.1 5.9 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 PIK60953.1 - 8.4e-19 67.8 1.3 0.0053 16.9 0.0 8.3 6 3 0 6 6 6 3 Immunoglobulin V-set domain SH3_1 PF00018.28 PIK60953.1 - 3.6e-12 45.7 1.4 1.1e-10 41.0 0.6 2.8 2 0 0 2 2 2 1 SH3 domain C2-set_2 PF08205.12 PIK60953.1 - 6.7e-11 42.1 0.2 0.75 9.9 0.0 6.0 5 0 0 5 5 5 4 CD80-like C2-set immunoglobulin domain fn3 PF00041.21 PIK60953.1 - 1.4e-10 41.4 2.6 6.1e-10 39.3 2.6 2.2 1 0 0 1 1 1 1 Fibronectin type III domain SH3_9 PF14604.6 PIK60953.1 - 2.4e-07 30.5 0.3 9.5e-07 28.6 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK60953.1 - 1.8e-06 27.5 0.0 2.2e-05 24.0 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 PIK60953.1 - 1.4e-05 25.2 4.3 0.0002 21.6 0.2 3.3 2 0 0 2 2 2 1 Bacterial SH3 domain BiPBP_C PF06832.12 PIK60953.1 - 6e-05 23.0 0.0 1.8 8.6 0.0 4.9 6 0 0 6 6 5 1 Penicillin-Binding Protein C-terminus Family Tissue_fac PF01108.17 PIK60953.1 - 0.00024 20.9 0.2 0.00074 19.3 0.2 1.9 1 0 0 1 1 1 1 Tissue factor Izumo-Ig PF16706.5 PIK60953.1 - 0.0012 18.8 0.1 1.6 8.8 0.0 4.4 5 0 0 5 5 4 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK60953.1 - 0.0079 16.5 12.2 0.077 13.4 0.0 5.2 7 0 0 7 7 6 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 PIK60953.1 - 0.079 13.2 0.3 36 4.6 0.0 5.0 6 1 1 7 7 6 0 Natural killer cell receptor 2B4 Ig_5 PF16681.5 PIK60953.1 - 0.12 12.8 6.7 3.6 8.1 0.0 5.5 8 0 0 8 8 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 PIK60954.1 - 1e-98 323.5 5.4 1.8e-18 66.4 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60954.1 - 5.2e-67 222.4 0.2 2.9e-12 47.0 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 PIK60954.1 - 8.4e-41 138.1 3.0 8.4e-08 32.3 0.0 6.2 6 0 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 PIK60954.1 - 8.1e-40 135.0 0.0 1e-09 38.6 0.0 6.3 5 1 1 6 6 6 6 Immunoglobulin domain V-set PF07686.17 PIK60954.1 - 1.7e-20 73.2 4.7 0.0036 17.5 0.1 9.4 6 5 0 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60954.1 - 2.9e-13 49.7 0.1 0.023 14.8 0.0 5.6 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK60954.1 - 8e-09 35.4 0.6 1.6 8.9 0.0 5.3 5 0 0 5 5 5 4 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK60954.1 - 3.5e-08 33.7 0.6 2.1 8.8 0.0 5.5 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK60954.1 - 4.2e-06 26.9 4.6 3.6 7.9 0.2 6.1 6 0 0 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 PIK60954.1 - 9.3e-05 22.6 0.0 2 8.7 0.0 5.0 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 THB PF18362.1 PIK60954.1 - 0.00031 20.3 0.3 0.00064 19.3 0.3 1.5 1 0 0 1 1 1 1 Tri-helix bundle domain Ig_6 PF18452.1 PIK60954.1 - 0.0016 18.0 0.0 0.26 10.9 0.1 3.8 4 0 0 4 4 4 1 Immunoglobulin domain ACAS_N PF16177.5 PIK60954.1 - 0.062 13.2 1.9 50 3.9 0.0 4.1 4 0 0 4 4 4 0 Acetyl-coenzyme A synthetase N-terminus Mitochondr_Som1 PF11093.8 PIK60954.1 - 0.066 13.2 0.3 20 5.3 0.1 2.9 2 0 0 2 2 2 0 Mitochondrial export protein Som1 DUF4198 PF10670.9 PIK60954.1 - 1.1 9.6 14.2 8 6.8 0.0 5.2 3 2 0 5 5 5 0 Domain of unknown function (DUF4198) I-set PF07679.16 PIK60955.1 - 1.6e-92 303.7 32.7 2.1e-14 53.3 0.0 9.7 9 0 0 9 9 9 8 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60955.1 - 3e-72 239.2 29.8 7.7e-12 45.7 0.2 10.7 14 0 0 14 14 10 8 Immunoglobulin domain fn3 PF00041.21 PIK60955.1 - 6.5e-69 228.3 31.9 3.7e-17 62.4 0.2 13.3 8 1 5 13 13 13 8 Fibronectin type III domain ig PF00047.25 PIK60955.1 - 5.1e-62 206.0 18.2 5.1e-12 45.8 0.2 8.4 8 0 0 8 8 8 7 Immunoglobulin domain Ig_2 PF13895.6 PIK60955.1 - 1.6e-50 169.3 0.7 6e-08 32.9 0.0 8.2 7 1 1 8 8 8 6 Immunoglobulin domain V-set PF07686.17 PIK60955.1 - 3.5e-35 120.5 17.7 2.3e-05 24.5 0.2 11.9 7 6 1 8 8 8 7 Immunoglobulin V-set domain C1-set PF07654.15 PIK60955.1 - 7.7e-27 93.5 29.8 0.00013 22.3 0.3 12.5 13 0 0 13 13 13 4 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK60955.1 - 9.1e-19 67.3 13.6 0.0018 18.3 0.1 7.5 6 1 1 7 7 7 5 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK60955.1 - 5.2e-12 45.8 25.1 0.017 15.3 0.5 7.2 7 0 0 7 7 7 5 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 PIK60955.1 - 1.5e-06 28.5 23.3 0.22 11.9 0.5 7.3 7 0 0 7 7 7 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain BiPBP_C PF06832.12 PIK60955.1 - 2e-05 24.6 0.1 0.18 11.9 0.0 5.5 6 0 0 6 6 6 1 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.12 PIK60955.1 - 5.1e-05 23.3 6.1 11 6.1 0.0 6.7 5 1 0 6 6 6 1 CD80-like C2-set immunoglobulin domain Secretin_N PF03958.17 PIK60955.1 - 5.3e-05 23.5 0.0 35 4.9 0.0 5.4 5 1 1 6 6 5 0 Bacterial type II/III secretion system short domain Ig_6 PF18452.1 PIK60955.1 - 0.00037 20.0 0.0 3.4 7.3 0.0 5.1 5 0 0 5 5 5 1 Immunoglobulin domain TIG PF01833.24 PIK60955.1 - 0.037 14.1 1.8 65 3.7 0.0 5.5 6 0 0 6 6 6 0 IPT/TIG domain GPI-anchored PF10342.9 PIK60955.1 - 1.7 9.5 46.9 50 4.8 0.1 12.2 14 1 1 15 15 13 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family fn3 PF00041.21 PIK60956.1 - 6.1e-285 920.6 83.8 2.7e-19 69.3 0.3 19.8 19 1 1 20 20 20 19 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK60956.1 - 8e-50 167.4 48.9 0.00018 22.0 0.3 17.7 16 2 0 16 16 16 13 Purple acid Phosphatase, N-terminal domain GPI-anchored PF10342.9 PIK60956.1 - 2.2e-22 79.6 73.7 0.35 11.7 0.3 17.8 18 1 0 18 18 18 10 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family fn3_2 PF16893.5 PIK60956.1 - 1.3e-21 76.5 6.9 7.1 6.9 0.0 14.6 15 0 0 15 15 14 1 Fibronectin type III domain I-set PF07679.16 PIK60956.1 - 1.6e-13 50.5 8.1 0.83 9.8 0.0 12.7 13 0 0 13 13 13 1 Immunoglobulin I-set domain Haem_degrading PF03928.14 PIK60956.1 - 2.3e-10 40.5 0.1 40 4.3 0.0 8.7 9 0 0 9 9 9 0 Haem-degrading C1-set PF07654.15 PIK60956.1 - 1.5e-09 38.1 11.2 1.2e+02 3.1 0.0 11.3 11 0 0 11 11 10 0 Immunoglobulin C1-set domain hemP PF10636.9 PIK60956.1 - 1.1e-08 34.8 2.2 70 3.3 0.0 10.8 12 0 0 12 12 12 0 Hemin uptake protein hemP Interfer-bind PF09294.10 PIK60956.1 - 2.2e-07 31.1 1.5 7.8 6.9 0.0 10.7 15 0 0 15 15 14 1 Interferon-alpha/beta receptor, fibronectin type III Arylsulfotran_N PF17425.2 PIK60956.1 - 4.8e-07 29.7 11.9 56 3.9 0.0 10.0 11 0 0 11 11 10 0 Arylsulfotransferase Ig-like domain DUF4998 PF16389.5 PIK60956.1 - 3.7e-06 26.7 2.3 3.6 7.1 0.0 6.4 5 1 0 5 5 5 1 Domain of unknown function DUF2369 PF10179.9 PIK60956.1 - 4.7e-06 26.9 11.5 15 6.1 0.1 11.0 13 0 0 13 13 13 0 Uncharacterised conserved protein (DUF2369) Ig_3 PF13927.6 PIK60956.1 - 4.8e-06 27.1 19.1 6.8 7.4 0.2 10.5 10 0 0 10 10 10 1 Immunoglobulin domain CDKN3 PF05706.12 PIK60956.1 - 2e-05 24.3 0.0 1.5e+02 2.0 0.0 8.1 10 1 0 10 10 9 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) bMG6 PF17962.1 PIK60956.1 - 0.0021 18.2 0.9 11 6.2 0.0 5.9 7 0 0 7 7 6 0 Bacterial macroglobulin domain 6 ChitinaseA_N PF08329.10 PIK60956.1 - 0.13 11.9 0.1 17 5.1 0.0 4.4 6 0 0 6 6 6 0 Chitinase A, N-terminal domain DUF1093 PF06486.11 PIK60956.1 - 0.73 10.6 9.1 2.5 8.9 0.2 5.5 5 0 0 5 5 5 0 Protein of unknown function (DUF1093) DUF2057 PF09829.9 PIK60956.1 - 3.2 7.9 6.4 1e+02 2.9 0.1 4.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2057) fn3 PF00041.21 PIK60957.1 - 4.6e-107 350.6 31.4 3.5e-16 59.3 0.7 9.1 9 0 0 9 9 9 8 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK60957.1 - 9.3e-11 42.2 18.7 0.49 11.0 0.2 8.1 7 1 0 8 8 8 4 Purple acid Phosphatase, N-terminal domain I-set PF07679.16 PIK60957.1 - 3.4e-10 39.8 0.2 1.7 8.7 0.0 6.3 6 0 0 6 6 6 4 Immunoglobulin I-set domain bMG6 PF17962.1 PIK60957.1 - 5.9e-07 29.6 3.3 0.83 9.8 0.1 5.6 6 0 0 6 6 6 3 Bacterial macroglobulin domain 6 fn3_2 PF16893.5 PIK60957.1 - 8.9e-07 29.0 0.0 2.9 8.1 0.0 5.7 6 0 0 6 6 6 1 Fibronectin type III domain DUF1093 PF06486.11 PIK60957.1 - 0.0023 18.6 3.8 3.9 8.2 0.1 4.2 4 0 0 4 4 4 2 Protein of unknown function (DUF1093) DUF2171 PF09939.9 PIK60957.1 - 0.023 15.0 0.3 9.8 6.5 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2171) ASH PF15780.5 PIK60957.1 - 0.047 13.9 4.1 0.47 10.7 0.3 4.4 4 1 0 4 4 4 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Reeler PF02014.16 PIK60957.1 - 0.056 14.2 9.0 32 5.3 0.1 6.2 5 2 0 6 6 6 0 Reeler domain fn3 PF00041.21 PIK60958.1 - 1.7e-35 121.2 1.9 1.4e-17 63.8 0.1 2.6 3 0 0 3 3 3 2 Fibronectin type III domain fn3_2 PF16893.5 PIK60958.1 - 5.3e-08 32.9 0.0 0.0011 19.0 0.0 2.8 2 1 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK60958.1 - 1.7e-06 28.5 0.5 0.003 18.1 0.2 2.8 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 PIK60958.1 - 2.6e-06 27.2 0.0 0.012 15.5 0.0 2.2 2 0 0 2 2 2 2 Tissue factor I-set PF07679.16 PIK60958.1 - 0.064 13.3 0.1 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain fn3 PF00041.21 PIK60959.1 - 7.2e-64 212.1 11.6 1.2e-16 60.8 0.1 6.5 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 PIK60959.1 - 2.1e-17 63.0 0.2 2e-14 53.4 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 PIK60959.1 - 2.6e-08 34.3 8.2 0.0024 18.4 0.0 6.7 7 1 0 7 7 7 2 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 PIK60959.1 - 7e-07 29.8 0.1 1.6e-05 25.4 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK60959.1 - 2.9e-05 24.2 0.2 0.00016 21.8 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain fn3_2 PF16893.5 PIK60959.1 - 0.0002 21.4 0.0 3.6 7.8 0.0 4.8 6 0 0 6 6 6 1 Fibronectin type III domain Ig_2 PF13895.6 PIK60959.1 - 0.026 14.9 0.0 0.074 13.4 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Collagen_bind_2 PF12904.7 PIK60959.1 - 0.1 12.6 0.5 7.7 6.6 0.0 3.4 4 0 0 4 4 4 0 Putative collagen-binding domain of a collagenase bMG6 PF17962.1 PIK60959.1 - 0.15 12.2 0.6 39 4.4 0.1 3.8 4 0 0 4 4 4 0 Bacterial macroglobulin domain 6 fn3 PF00041.21 PIK60960.1 - 3.2e-50 168.4 2.7 1.7e-18 66.7 0.1 4.2 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK60960.1 - 2.1e-05 25.0 1.8 1.2 9.8 0.1 4.4 4 2 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 PIK60960.1 - 0.00076 19.4 0.0 0.6 10.1 0.0 3.9 4 1 0 4 4 4 1 Y_Y_Y domain fn3 PF00041.21 PIK60961.1 - 1.4e-07 31.7 0.1 1.8e-07 31.4 0.1 1.1 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK60961.1 - 0.0074 16.8 0.2 0.0095 16.5 0.2 1.3 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain I-set PF07679.16 PIK60962.1 - 3.6e-18 65.4 0.1 1.2e-15 57.4 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60962.1 - 1.9e-14 54.0 0.1 3.4e-13 50.0 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain fn3 PF00041.21 PIK60962.1 - 9.5e-10 38.7 0.0 2.1e-09 37.6 0.0 1.5 2 0 0 2 2 2 1 Fibronectin type III domain Ig_2 PF13895.6 PIK60962.1 - 6.7e-09 36.0 0.1 1.3e-08 35.0 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK60962.1 - 2.1e-07 31.0 0.2 7e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK60962.1 - 1.6e-05 25.0 0.3 0.0018 18.5 0.3 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60962.1 - 0.016 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.11 PIK60962.1 - 0.025 14.5 0.1 0.043 13.8 0.1 1.4 1 1 0 1 1 1 0 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 PIK60962.1 - 0.04 14.0 0.1 0.091 12.8 0.1 1.6 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK60962.1 - 0.068 13.7 0.0 0.16 12.5 0.0 1.6 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 PIK60963.1 - 0.042 14.2 0.1 0.33 11.3 0.0 2.0 2 0 0 2 2 2 0 Fibronectin type III domain I-set PF07679.16 PIK60964.1 - 8.6e-68 224.5 0.0 1.3e-22 79.7 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin I-set domain fn3 PF00041.21 PIK60964.1 - 8e-63 208.8 9.2 4.7e-16 58.9 0.4 6.2 5 1 1 6 6 6 5 Fibronectin type III domain Ig_3 PF13927.6 PIK60964.1 - 2.2e-45 153.2 0.0 2.7e-15 56.7 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain Pkinase PF00069.25 PIK60964.1 - 1.6e-35 122.8 3.0 2.1e-35 122.4 3.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK60964.1 - 1.4e-23 83.6 0.6 2.1e-23 82.9 0.6 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_2 PF13895.6 PIK60964.1 - 9.3e-23 80.4 0.0 7.9e-10 38.9 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 PIK60964.1 - 2e-20 72.7 0.0 2.8e-13 49.8 0.0 4.3 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK60964.1 - 5.2e-13 49.1 0.1 0.0023 18.1 0.1 5.7 4 3 0 4 4 4 2 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 PIK60964.1 - 1.5e-10 41.5 2.3 0.003 18.1 0.3 5.5 4 2 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 PIK60964.1 - 8.2e-05 22.6 0.6 0.68 10.0 0.0 3.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 PIK60964.1 - 0.00015 21.9 0.0 0.011 16.0 0.0 2.9 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 C1-set PF07654.15 PIK60964.1 - 0.0011 19.3 0.0 0.16 12.3 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Kdo PF06293.14 PIK60964.1 - 0.012 15.0 1.0 0.02 14.3 1.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhoD_N PF16655.5 PIK60964.1 - 0.016 15.7 0.0 18 5.9 0.0 3.7 4 0 0 4 4 2 0 PhoD-like phosphatase, N-terminal domain RIO1 PF01163.22 PIK60964.1 - 0.088 12.4 1.7 0.17 11.4 1.7 1.4 1 0 0 1 1 1 0 RIO1 family DUF11 PF01345.18 PIK60964.1 - 0.21 11.9 0.6 4.5 7.6 0.2 3.3 4 1 0 4 4 4 0 Domain of unknown function DUF11 I-set PF07679.16 PIK60965.1 - 1.4e-46 156.4 0.1 4.9e-24 84.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60965.1 - 1.2e-29 102.7 0.0 1.9e-15 57.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Pkinase PF00069.25 PIK60965.1 - 2.5e-20 73.0 0.0 3.7e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 PIK60965.1 - 1e-16 61.0 0.0 1.8e-09 37.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK60965.1 - 1.8e-15 56.9 0.3 3.5e-09 36.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK60965.1 - 1e-11 44.9 0.2 0.00032 20.8 0.0 4.4 3 1 0 3 3 3 2 Immunoglobulin V-set domain C1-set PF07654.15 PIK60965.1 - 3.6e-06 27.3 0.4 0.0061 16.9 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 PIK60965.1 - 7.7e-06 26.1 0.0 0.28 11.4 0.0 3.1 3 0 0 3 3 3 2 Natural killer cell receptor 2B4 Pkinase_Tyr PF07714.17 PIK60965.1 - 4.3e-05 22.9 0.0 7.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_4 PF16680.5 PIK60965.1 - 0.0012 19.0 1.1 0.71 10.2 0.1 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 PIK60965.1 - 0.062 13.4 0.3 3.6 7.7 0.0 2.8 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 PIK60965.1 - 0.13 11.9 0.0 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK60966.1 - 6.5e-28 96.6 0.0 1.8e-18 66.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60966.1 - 6.7e-16 58.7 0.0 2e-09 37.9 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK60966.1 - 5.9e-09 36.0 0.2 0.00042 20.4 0.1 3.1 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 PIK60966.1 - 4e-06 27.0 0.0 0.0019 18.3 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK60966.1 - 7.7e-06 26.2 0.0 0.063 13.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain HTH_32 PF13565.6 PIK60966.1 - 0.015 15.9 0.6 0.037 14.6 0.6 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Ig_6 PF18452.1 PIK60966.1 - 0.21 11.2 0.0 0.6 9.7 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK60967.1 - 6.9e-46 154.2 0.0 1.1e-22 79.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK60967.1 - 3.7e-29 101.1 0.3 1.1e-15 58.0 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK60967.1 - 2.3e-18 66.1 0.0 6.1e-12 45.6 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 PIK60967.1 - 1.7e-17 63.5 0.0 9.4e-11 41.9 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK60967.1 - 4.3e-10 39.7 0.2 0.00042 20.5 0.1 4.8 2 2 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK60967.1 - 0.028 14.5 0.0 0.61 10.2 0.0 2.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 PIK60967.1 - 0.056 13.5 0.0 6.9 6.8 0.0 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain C1-set PF07654.15 PIK60967.1 - 0.086 13.2 0.0 18 5.8 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Frizzled PF01534.17 PIK60968.1 - 1.6e-135 451.3 16.5 2.1e-135 451.0 16.5 1.0 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 PIK60968.1 - 8.3e-12 45.7 0.9 2e-11 44.5 0.9 1.6 1 0 0 1 1 1 1 Fz domain Pox_A14 PF05767.12 PIK60968.1 - 0.054 13.7 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 FxsA PF04186.13 PIK60968.1 - 0.14 12.3 2.3 0.47 10.6 0.0 2.9 2 1 0 2 2 2 0 FxsA cytoplasmic membrane protein FA_FANCE PF11510.8 PIK60969.1 - 4.6e-16 59.0 6.0 5.1e-10 39.1 1.5 2.0 1 1 1 2 2 2 2 Fanconi Anaemia group E protein FANCE DUF2383 PF09537.10 PIK60969.1 - 0.1 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DAO_C PF16901.5 PIK60970.1 - 7e-38 129.3 0.0 1.4e-37 128.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 PIK60970.1 - 3.4e-14 53.1 0.2 9.6e-14 51.6 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair DAO PF01266.24 PIK60970.1 - 1.2e-13 51.3 0.0 2.7e-08 33.8 0.0 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase EF-hand_1 PF00036.32 PIK60970.1 - 4.6e-10 38.3 0.0 6.8e-05 22.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK60970.1 - 5.2e-10 39.0 0.1 6.4e-09 35.5 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK60970.1 - 1.9e-08 33.5 0.1 0.0025 17.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK60970.1 - 0.00016 21.0 0.3 0.026 14.0 0.1 2.4 2 0 0 2 2 2 1 EF hand FAD_binding_2 PF00890.24 PIK60970.1 - 0.012 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 PIK60971.1 - 1.6e-14 54.3 0.3 2.3e-14 53.7 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK60971.1 - 2.2e-06 27.0 0.6 3e-06 26.6 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 PIK60971.1 - 2.5e-06 27.1 0.2 3.3e-06 26.7 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 PIK60971.1 - 0.00041 19.7 0.1 0.00071 18.9 0.1 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 PIK60971.1 - 0.00064 18.9 0.2 0.00084 18.5 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 PIK60971.1 - 0.0053 16.0 0.2 0.0076 15.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 PIK60971.1 - 0.0065 15.2 0.6 0.0087 14.8 0.1 1.4 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 PIK60971.1 - 0.024 15.2 0.2 0.051 14.2 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK60971.1 - 0.026 13.7 0.1 0.035 13.4 0.1 1.1 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 PIK60971.1 - 0.033 14.4 1.5 0.046 14.0 0.4 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 PIK60971.1 - 0.038 13.0 0.3 0.12 11.4 0.1 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 PIK60971.1 - 0.042 13.1 0.0 0.05 12.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Transposase_20 PF02371.16 PIK60971.1 - 0.099 13.0 0.1 1.2 9.5 0.0 2.2 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family CPSase_L_D2 PF02786.17 PIK60972.1 - 1.2e-106 354.9 2.7 1.8e-73 246.6 0.3 3.0 3 0 0 3 3 3 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 PIK60972.1 - 7.3e-51 171.3 0.0 2.1e-50 169.9 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 PIK60972.1 - 6.8e-41 140.1 0.0 2.1e-40 138.6 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 PIK60972.1 - 3.7e-38 130.6 0.1 8e-38 129.5 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 PIK60972.1 - 1.1e-18 67.4 0.2 6.8e-11 42.0 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 PIK60972.1 - 9.4e-18 64.5 0.2 9.3e-08 31.9 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 PIK60972.1 - 3.8e-16 59.0 0.1 6.3e-15 55.1 0.0 2.8 3 0 0 3 3 3 1 MGS-like domain ATPgrasp_Ter PF15632.6 PIK60972.1 - 9.2e-10 38.4 0.2 3.7e-05 23.5 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 PIK60972.1 - 0.00014 22.0 0.2 0.18 11.9 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_5 PF13549.6 PIK60972.1 - 0.0015 18.0 0.1 1.8 8.0 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 PIK60972.1 - 0.0026 17.6 0.6 0.28 10.9 0.6 2.5 1 1 0 1 1 1 1 Peptidase C26 MerR-DNA-bind PF09278.11 PIK60972.1 - 0.16 12.5 0.1 8 7.1 0.2 2.9 3 0 0 3 3 3 0 MerR, DNA binding VHP PF02209.19 PIK60973.1 - 6.8e-17 61.2 1.5 1.4e-16 60.2 1.5 1.6 1 0 0 1 1 1 1 Villin headpiece domain Gelsolin PF00626.22 PIK60974.1 - 2.2e-62 206.9 0.9 7.4e-14 51.4 0.0 6.6 7 0 0 7 7 7 5 Gelsolin repeat DUF5010 PF16402.5 PIK60974.1 - 0.064 12.1 0.1 0.1 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) DMAP_binding PF06464.11 PIK60975.1 - 0.00029 21.6 0.2 0.00055 20.7 0.2 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain AMP-binding PF00501.28 PIK60976.1 - 5.9e-72 242.6 1.9 3.2e-41 141.3 0.2 3.1 2 1 0 2 2 2 2 AMP-binding enzyme Spore_YhcN_YlaJ PF09580.10 PIK60977.1 - 0.13 12.4 0.2 0.2 11.7 0.2 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Helicase_C PF00271.31 PIK60978.1 - 1.6e-25 89.6 0.0 3e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK60978.1 - 1.3e-05 25.1 0.0 5.3e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD PF00270.29 PIK60979.1 - 1e-18 67.7 0.0 1.3e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 PIK60979.1 - 0.00041 20.4 0.0 0.00044 20.3 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 PIK60979.1 - 0.074 12.6 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arc PF03869.14 PIK60979.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Arc-like DNA binding domain Glyco_transf_10 PF00852.19 PIK60980.1 - 2.2e-49 167.5 4.4 3.4e-49 167.0 4.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK60980.1 - 2.1e-09 37.8 0.9 5.1e-05 23.7 0.1 2.6 2 0 0 2 2 2 2 Fucosyltransferase, N-terminal SDA1 PF05285.12 PIK60980.1 - 5.4e-05 22.8 33.1 0.0001 21.9 33.1 1.4 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 PIK60980.1 - 0.02 14.3 33.7 0.033 13.6 33.7 1.3 1 0 0 1 1 1 0 BUD22 Zincin_2 PF10103.9 PIK60980.1 - 0.067 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Zincin-like metallopeptidase Nop14 PF04147.12 PIK60980.1 - 0.41 8.8 51.4 0.6 8.3 51.4 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 PIK60980.1 - 1.1 7.9 15.7 1.8 7.3 15.7 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Glyco_transf_10 PF00852.19 PIK60981.1 - 3.2e-43 147.5 1.7 3.5e-43 147.4 1.7 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Corona_RPol_N PF06478.13 PIK60981.1 - 0.0044 16.1 0.4 0.0095 15.0 0.1 1.6 2 0 0 2 2 2 1 Coronavirus RPol N-terminus TPR_1 PF00515.28 PIK60982.1 - 0.00029 20.5 0.1 0.00077 19.2 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK60982.1 - 0.00029 20.4 0.3 0.0005 19.7 0.3 1.4 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 PIK60982.1 - 0.0028 17.6 0.1 0.0067 16.4 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK60982.1 - 0.016 15.4 0.7 0.034 14.4 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat GET2 PF08690.10 PIK60982.1 - 0.052 13.2 1.1 0.054 13.2 1.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 MOSC_N PF03476.16 PIK60982.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 MOSC N-terminal beta barrel domain GerD PF17898.1 PIK60982.1 - 0.24 11.3 4.3 0.53 10.3 4.3 1.5 1 0 0 1 1 1 0 Spore germination GerD central core domain DUF4245 PF14030.6 PIK60983.1 - 0.091 12.8 0.4 0.12 12.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) DUF4083 PF13314.6 PIK60983.1 - 2 8.4 6.9 1.7 8.7 5.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DPPIV_N PF00930.21 PIK60984.1 - 2.7e-29 102.1 0.6 5.6e-25 87.9 0.2 2.1 2 0 0 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 PIK60985.1 - 2.3e-26 92.6 0.3 7.2e-26 91.0 0.3 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 PIK60985.1 - 0.00038 20.1 0.1 0.0062 16.2 0.0 2.4 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Orf78 PF06024.12 PIK60985.1 - 0.00099 19.4 21.4 0.0083 16.4 2.4 4.4 3 1 1 4 4 3 3 Orf78 (ac78) DUF4834 PF16118.5 PIK60985.1 - 0.0056 17.6 1.2 0.0056 17.6 1.2 4.6 2 1 1 3 3 2 1 Domain of unknown function (DUF4834) DUF2207 PF09972.9 PIK60985.1 - 0.22 10.3 12.7 4.8 5.8 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3619 PF12279.8 PIK60985.1 - 0.28 11.5 2.7 15 6.0 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3619) SARAF PF06682.12 PIK60985.1 - 0.28 10.8 8.8 4.1 7.0 0.0 3.5 2 1 2 4 4 4 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4448 PF14610.6 PIK60985.1 - 0.39 10.5 7.7 0.29 10.9 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4448) SPX PF03105.19 PIK60985.1 - 2.7 7.8 15.7 48 3.7 15.6 2.2 1 1 0 1 1 1 0 SPX domain DUF2370 PF10176.9 PIK60985.1 - 4.5 6.8 8.1 1 8.9 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) DUF2721 PF11026.8 PIK60985.1 - 8.9 6.2 13.1 5.4 6.9 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) 7tm_1 PF00001.21 PIK60987.1 - 7.5e-31 107.4 6.8 1.7e-17 63.6 1.8 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK60987.1 - 9.5e-05 21.9 15.5 0.00044 19.7 5.7 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 PIK60987.1 - 0.00026 20.5 8.0 0.051 12.9 0.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.8 PIK60987.1 - 0.00081 19.2 3.8 0.00081 19.2 3.8 1.9 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Amidase_2 PF01510.25 PIK60988.1 - 0.0018 18.7 0.0 0.0024 18.3 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Vps8 PF12816.7 PIK60989.1 - 5.1e-64 215.5 2.0 1.6e-62 210.5 0.2 3.6 3 1 1 5 5 5 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 PIK60989.1 - 1.2e-09 38.2 0.5 0.00013 21.8 0.0 4.0 3 1 0 3 3 3 2 Region in Clathrin and VPS Ank_3 PF13606.6 PIK60991.1 - 4.3e-20 69.7 0.3 9.5e-06 25.6 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK60991.1 - 2.5e-19 69.1 0.9 1.2e-07 31.8 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK60991.1 - 3.5e-19 69.2 0.1 3.1e-17 62.9 0.1 2.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK60991.1 - 1.6e-18 66.2 1.6 9.1e-05 22.7 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 PIK60991.1 - 1.1e-17 64.1 0.2 1.1e-09 38.7 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) BRCT PF00533.26 PIK60991.1 - 1.3e-17 63.9 0.0 1e-11 45.1 0.0 2.8 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 PIK60991.1 - 5.6e-11 42.7 0.0 0.00047 20.5 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 PIK60991.1 - 1.3e-07 31.4 0.0 2.5e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 PIK60991.1 - 0.00042 20.2 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain SH3_2 PF07653.17 PIK60991.1 - 0.081 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain AUX_IAA PF02309.16 PIK60992.1 - 0.47 10.3 2.8 1.1 9.0 2.8 1.6 1 1 0 1 1 1 0 AUX/IAA family MCRS_N PF13325.6 PIK60993.1 - 8.8e-77 257.6 6.9 2.6e-76 256.1 6.9 1.7 1 1 0 1 1 1 1 N-terminal region of micro-spherule protein FHA PF00498.26 PIK60993.1 - 2.6e-06 27.7 0.0 4.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain Myb_DNA-binding PF00249.31 PIK60993.1 - 0.00087 19.4 0.4 0.91 9.8 0.0 3.6 3 1 0 3 3 3 1 Myb-like DNA-binding domain Y_phosphatase PF00102.27 PIK60994.1 - 3.4e-41 141.4 0.3 1.4e-40 139.3 0.3 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase RVT_1 PF00078.27 PIK60995.1 - 4.7e-38 130.9 0.0 6.5e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK60996.1 - 1.2e-38 132.9 0.0 1.4e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK60997.1 - 1.2e-06 28.3 2.9 0.00043 20.2 0.2 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK60997.1 - 0.00031 20.6 5.1 0.15 12.1 1.0 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK60997.1 - 0.015 15.2 0.2 0.015 15.2 0.2 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK60997.1 - 0.015 15.0 0.8 0.015 15.0 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK60997.1 - 0.048 13.4 4.6 3.3 7.5 0.4 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 PIK60997.1 - 1.4 8.8 5.8 1.8 8.5 0.2 2.9 2 0 0 2 2 2 0 Zinc knuckle SAP PF02037.27 PIK60998.1 - 2.9e-08 33.3 0.4 2.9e-08 33.3 0.4 2.0 3 0 0 3 3 3 1 SAP domain Ish1 PF10281.9 PIK60998.1 - 0.01 16.1 0.1 0.023 15.0 0.1 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Telomere_Sde2_2 PF13297.6 PIK60998.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Telomere stability C-terminal TPR_1 PF00515.28 PIK61001.1 - 3.9e-25 86.6 18.9 1.3e-06 27.9 0.2 8.5 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61001.1 - 5.2e-22 76.1 16.2 0.0042 17.1 0.2 8.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61001.1 - 9.1e-19 66.0 21.0 0.0038 17.3 0.0 7.8 9 0 0 9 9 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61001.1 - 9.8e-18 63.6 12.7 2.3e-07 30.4 0.1 5.9 5 1 1 6 6 5 3 TPR repeat TPR_14 PF13428.6 PIK61001.1 - 1.3e-15 56.7 8.0 0.0015 19.2 0.0 6.8 2 1 5 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61001.1 - 3e-13 49.8 15.6 0.0011 19.2 0.1 5.3 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61001.1 - 2.3e-12 47.3 7.3 9e-05 23.0 0.4 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 PIK61001.1 - 2.9e-11 42.9 9.3 0.039 14.3 0.0 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 PIK61001.1 - 5.8e-09 36.0 8.3 0.0027 17.8 0.1 5.3 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 PIK61001.1 - 1.3e-05 25.5 17.0 0.71 10.6 0.2 8.1 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61001.1 - 3.2e-05 24.3 19.9 0.041 14.4 0.2 6.1 3 1 4 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 PIK61001.1 - 5.1e-05 22.6 5.6 0.053 12.7 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat ST7 PF04184.12 PIK61001.1 - 0.0066 15.0 0.7 0.014 13.9 0.2 1.7 2 0 0 2 2 2 1 ST7 protein TPR_7 PF13176.6 PIK61001.1 - 0.0077 16.2 4.3 29 5.0 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat COG2 PF06148.11 PIK61001.1 - 0.02 15.0 1.7 0.033 14.3 0.7 1.9 2 0 0 2 2 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_10 PF13374.6 PIK61001.1 - 0.1 12.5 14.4 3.6 7.6 0.0 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 PIK61001.1 - 0.15 11.7 1.7 5.8 6.6 0.0 3.1 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_21 PF09976.9 PIK61001.1 - 0.15 11.7 18.2 0.065 12.9 0.7 3.7 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain SHNi-TPR PF10516.9 PIK61001.1 - 0.28 10.6 2.7 8.4 5.9 0.0 3.8 4 0 0 4 4 4 0 SHNi-TPR TPR_MalT PF17874.1 PIK61001.1 - 0.5 9.7 8.0 0.32 10.3 2.9 2.9 2 1 2 4 4 4 0 MalT-like TPR region Mad3_BUB1_I PF08311.12 PIK61001.1 - 4.8 7.2 6.2 12 5.9 0.9 3.4 3 1 0 3 3 3 0 Mad3/BUB1 homology region 1 ANAPC5 PF12862.7 PIK61001.1 - 5.1 7.2 9.6 2.2 8.4 0.6 3.9 3 3 1 4 4 4 0 Anaphase-promoting complex subunit 5 PBP_GOBP PF01395.22 PIK61001.1 - 7.4 6.8 12.0 0.14 12.3 3.0 2.6 3 1 0 3 3 2 0 PBP/GOBP family DUF1387 PF07139.11 PIK61002.1 - 6.6 6.4 12.9 8.7 6.0 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) MFS_1 PF07690.16 PIK61003.1 - 3.8e-21 75.4 48.1 3.2e-20 72.4 45.5 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily G0-G1_switch_2 PF15103.6 PIK61003.1 - 0.22 11.9 0.5 2.7 8.4 0.0 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 MFS_1 PF07690.16 PIK61004.1 - 7.4e-16 58.0 6.2 8.8e-16 57.8 6.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 PIK61004.1 - 0.0021 17.0 7.5 0.0051 15.7 7.3 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter DUF550 PF04447.12 PIK61004.1 - 0.098 12.8 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF550) PDZ_6 PF17820.1 PIK61005.1 - 1.7e-11 43.8 0.1 3.1e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK61005.1 - 2.9e-08 33.9 0.1 3.8e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK61005.1 - 6.7e-05 23.2 0.1 9.3e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 PIK61005.1 - 0.00029 21.2 0.0 0.00032 21.0 0.0 1.1 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain DUF3394 PF11874.8 PIK61005.1 - 0.16 11.6 0.0 0.32 10.7 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3394) DUF2053 PF09767.9 PIK61006.1 - 6.2e-33 114.2 1.7 6.6e-33 114.1 1.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) RPN13_C PF16550.5 PIK61007.1 - 0.0024 18.0 0.0 0.0033 17.6 0.0 1.2 1 0 0 1 1 1 1 UCH-binding domain ASXH PF13919.6 PIK61007.1 - 0.0073 16.3 1.2 0.0092 16.0 0.2 1.6 2 0 0 2 2 2 1 Asx homology domain E7 PF00527.18 PIK61007.1 - 8.5 6.6 10.6 1.1 9.5 1.8 2.6 1 1 0 2 2 2 0 E7 protein, Early protein DUF5641 PF18701.1 PIK61008.1 - 3.6e-28 97.6 1.1 5.5e-28 97.0 1.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 PIK61008.1 - 1.9e-11 44.2 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK61008.1 - 0.0022 17.7 0.0 0.0085 15.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DUF3110 PF11360.8 PIK61008.1 - 0.095 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) NFRKB_winged PF14465.6 PIK61009.1 - 1.1e-09 38.4 3.4 1.1e-09 38.4 3.4 2.0 2 0 0 2 2 2 1 NFRKB Winged Helix-like DUF4452 PF14618.6 PIK61010.1 - 0.019 14.8 0.1 0.019 14.8 0.1 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4452) DNA_pol_phi PF04931.13 PIK61010.1 - 2.7 6.0 8.1 3.4 5.6 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pex19 PF04614.12 PIK61011.1 - 1.9e-07 31.1 0.3 1.9e-07 31.1 0.3 2.9 2 1 0 2 2 2 1 Pex19 protein family Ig_2 PF13895.6 PIK61013.1 - 1.3e-09 38.2 2.6 0.002 18.4 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK61013.1 - 5.2e-09 36.6 1.6 0.0021 18.6 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK61013.1 - 2.4e-07 30.7 0.1 0.038 14.1 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 PIK61013.1 - 0.0088 16.2 0.2 1.6 9.0 0.0 2.9 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 PIK61014.1 - 0.00018 21.5 0.1 0.27 11.3 0.0 3.3 3 1 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 PIK61014.1 - 0.0025 18.4 0.1 3.1 8.5 0.1 3.3 2 1 0 2 2 2 2 Immunoglobulin domain TPR_1 PF00515.28 PIK61015.1 - 0.0012 18.6 2.1 0.11 12.3 0.4 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat PhaC_N PF07167.13 PIK61015.1 - 0.078 12.6 1.5 0.34 10.5 0.0 2.7 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus TPR_11 PF13414.6 PIK61015.1 - 0.68 9.7 3.7 0.37 10.5 0.2 2.4 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.17 PIK61015.1 - 0.8 10.0 7.6 2 8.7 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SET PF00856.28 PIK61015.1 - 1.5 9.2 8.4 11 6.4 0.6 3.8 3 0 0 3 3 3 0 SET domain Ig_3 PF13927.6 PIK61017.1 - 2.6e-19 69.6 10.7 1.2e-09 38.6 1.2 4.4 3 1 1 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK61017.1 - 4.5e-16 58.7 2.2 1.3e-06 28.4 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61017.1 - 5.3e-15 55.5 8.8 3.7e-07 30.4 0.5 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK61017.1 - 1.2e-10 41.4 9.0 5.5e-07 29.7 0.3 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK61017.1 - 7.6e-05 22.9 5.8 2.6 8.3 0.2 5.2 4 2 1 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK61017.1 - 0.033 14.2 4.4 0.39 10.8 0.2 3.3 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Gal-3-0_sulfotr PF06990.11 PIK61018.1 - 4.5e-25 88.4 0.4 5.4e-25 88.1 0.4 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Kinesin PF00225.23 PIK61019.1 - 4.6e-19 68.5 2.8 1.7e-17 63.3 0.4 2.2 1 1 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 PIK61019.1 - 1.5e-17 63.9 0.5 3.3e-17 62.8 0.5 1.5 1 0 0 1 1 1 1 Microtubule binding Ig_3 PF13927.6 PIK61019.1 - 0.00014 22.3 1.4 0.075 13.6 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK61019.1 - 0.00018 21.6 0.2 0.0027 17.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK61019.1 - 0.00088 19.4 0.0 0.0035 17.5 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 PIK61019.1 - 0.0021 18.1 0.1 0.1 12.7 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain ODV-E18 PF10717.9 PIK61019.1 - 0.01 15.6 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF3169 PF11368.8 PIK61019.1 - 0.057 12.9 0.1 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF2140 PF09911.9 PIK61019.1 - 0.075 12.6 0.3 0.19 11.3 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF997 PF06196.12 PIK61019.1 - 0.13 12.3 0.2 0.48 10.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF997) Pkinase_Tyr PF07714.17 PIK61020.1 - 4.5e-08 32.7 0.0 5.2e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61020.1 - 9.5e-05 21.9 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain C1q PF00386.21 PIK61023.1 - 5e-32 110.8 0.1 6.3e-32 110.5 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 PIK61023.1 - 4.2e-06 26.4 43.5 0.031 14.0 25.9 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) FAT PF02259.23 PIK61024.1 - 1.7e-74 251.1 5.9 3.2e-40 138.4 1.4 3.4 3 0 0 3 3 3 2 FAT domain DUF3385 PF11865.8 PIK61024.1 - 2e-64 216.3 1.2 2.4e-60 203.1 0.1 4.2 4 0 0 4 4 4 2 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 PIK61024.1 - 5.9e-14 52.2 5.6 0.00039 20.8 0.0 7.3 6 2 1 7 7 7 4 HEAT repeats HEAT PF02985.22 PIK61024.1 - 1.1e-12 47.0 9.4 0.005 17.0 0.1 10.0 11 0 0 11 11 10 2 HEAT repeat HEAT_EZ PF13513.6 PIK61024.1 - 5.6e-11 42.7 19.1 0.26 11.8 0.3 11.5 13 1 1 14 14 12 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK61024.1 - 3.1e-07 30.9 0.9 0.7 10.5 0.0 7.2 6 1 1 7 7 7 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 PIK61024.1 - 5.6e-06 25.2 1.9 0.22 10.0 0.3 5.8 5 1 0 6 6 6 1 Adaptin N terminal region IFRD PF05004.13 PIK61024.1 - 1e-05 24.8 5.5 0.0015 17.7 0.1 3.9 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 PIK61024.1 - 0.0023 17.6 2.5 33 3.9 0.0 5.6 5 0 0 5 5 5 0 CLASP N terminal TPR_19 PF14559.6 PIK61024.1 - 0.026 15.0 2.3 5.2 7.7 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK61024.1 - 0.029 14.4 0.2 2.5 8.3 0.0 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat UME PF08064.13 PIK61024.1 - 0.037 14.0 0.9 2.6 8.0 0.0 4.4 4 0 0 4 4 4 0 UME (NUC010) domain Arm PF00514.23 PIK61024.1 - 0.043 13.9 16.3 0.086 12.9 0.1 5.9 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat TPR_2 PF07719.17 PIK61024.1 - 0.48 10.7 4.7 40 4.7 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat UbiA PF01040.18 PIK61025.1 - 2.8e-37 128.4 11.3 3.5e-37 128.1 11.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family HLH PF00010.26 PIK61026.1 - 1.1e-14 54.1 1.5 1.9e-14 53.3 1.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 PIK61026.1 - 2.2e-11 43.8 0.2 4.2e-11 42.9 0.2 1.5 1 0 0 1 1 1 1 Hairy Orange DUF2808 PF10989.8 PIK61027.1 - 0.016 15.2 0.7 0.033 14.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) HEPN_Swt1 PF18731.1 PIK61029.1 - 0.012 16.0 0.4 0.018 15.4 0.4 1.3 1 0 0 1 1 1 0 Swt1-like HEPN Dynamin_N PF00350.23 PIK61030.1 - 5.3e-39 134.0 2.6 7.2e-39 133.5 0.4 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 PIK61030.1 - 3.9e-06 26.9 0.1 0.00012 22.1 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK61030.1 - 0.0038 16.8 0.0 0.87 9.1 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B DUF1593 PF07632.11 PIK61030.1 - 0.0058 16.1 0.1 0.012 15.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Roc PF08477.13 PIK61030.1 - 0.014 15.6 0.1 0.41 10.9 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 PIK61030.1 - 0.14 12.6 0.0 0.41 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 PIK61030.1 - 0.78 9.4 0.0 0.78 9.4 0.0 3.1 2 2 2 4 4 4 0 AAA ATPase domain DUF5595 PF18077.1 PIK61030.1 - 1.8 8.7 6.2 14 5.9 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) Calx-beta PF03160.14 PIK61031.1 - 3e-11 43.4 7.5 1.7e-07 31.3 0.8 3.1 3 0 0 3 3 3 2 Calx-beta domain EGF PF00008.27 PIK61031.1 - 0.33 11.3 7.8 0.85 10.0 7.8 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 PIK61031.1 - 0.57 10.6 13.0 1.3 9.5 13.0 1.6 1 0 0 1 1 1 0 EGF-like domain CUB PF00431.20 PIK61032.1 - 1.2e-07 32.1 0.0 0.029 14.7 0.0 3.4 3 0 0 3 3 3 2 CUB domain Calx-beta PF03160.14 PIK61032.1 - 0.00017 21.7 10.5 0.0047 17.1 0.6 3.1 3 0 0 3 3 3 2 Calx-beta domain Ig_2 PF13895.6 PIK61032.1 - 0.0038 17.5 0.1 1.7 9.1 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK61032.1 - 0.074 13.7 0.4 8.2 7.1 0.1 3.1 3 0 0 3 3 3 0 Immunoglobulin domain SSF PF00474.17 PIK61033.1 - 3.2e-30 105.3 15.6 4.4e-30 104.9 15.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family NUDIX PF00293.28 PIK61034.1 - 1.1e-11 44.8 0.0 1.9e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Sugar_tr PF00083.24 PIK61035.1 - 2.5e-123 412.3 15.6 2.9e-123 412.1 15.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK61035.1 - 3.8e-21 75.4 22.9 3e-20 72.5 17.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 PIK61035.1 - 0.00033 19.7 0.6 0.00033 19.7 0.6 1.8 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM MFS_3 PF05977.13 PIK61035.1 - 0.033 12.6 9.2 0.031 12.7 0.6 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector Phage_holin_3_2 PF04550.12 PIK61035.1 - 0.22 12.1 4.0 0.71 10.5 4.0 1.9 1 0 0 1 1 1 0 Phage holin family 2 Sugar_tr PF00083.24 PIK61036.1 - 0.015 14.2 0.1 0.02 13.8 0.1 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Sugar_tr PF00083.24 PIK61038.1 - 4.3e-68 230.2 16.9 8.5e-54 183.1 3.4 3.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK61038.1 - 2.4e-16 59.6 13.1 2.4e-16 59.6 13.1 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily COX2-transmemb PF09125.10 PIK61038.1 - 0.048 13.5 1.5 0.14 12.0 1.5 1.8 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane Sugar_tr PF00083.24 PIK61040.1 - 2.2e-125 419.1 19.9 2.5e-125 418.9 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK61040.1 - 2.2e-19 69.6 41.7 1.8e-18 66.6 15.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.18 PIK61040.1 - 3.9e-07 29.2 0.3 3.3e-05 22.8 0.0 2.2 1 1 0 2 2 2 2 Reduced folate carrier Fructosamin_kin PF03881.14 PIK61041.1 - 6.2e-71 238.9 0.8 1.9e-69 234.0 0.8 2.0 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 PIK61041.1 - 1.8e-09 37.9 0.0 2.3e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family REJ PF02010.15 PIK61042.1 - 1.8e-59 201.7 8.7 2.2e-54 185.0 6.6 2.1 2 0 0 2 2 2 2 REJ domain DUF4489 PF14879.6 PIK61042.1 - 0.083 13.0 0.6 0.4 10.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4489) Mito_carr PF00153.27 PIK61044.1 - 2.4e-43 146.0 0.5 2.8e-21 75.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein COesterase PF00135.28 PIK61045.1 - 4.5e-59 200.7 0.0 9.2e-59 199.6 0.0 1.4 2 0 0 2 2 2 1 Carboxylesterase family AChE_tetra PF08674.10 PIK61045.1 - 8e-05 22.3 2.3 0.00027 20.6 2.3 1.9 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 PIK61046.1 - 2.1e-98 330.4 0.0 2.4e-98 330.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK61046.1 - 4.3e-09 36.6 0.5 2e-08 34.3 0.5 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold S1 PF00575.23 PIK61047.1 - 3.6e-11 43.3 0.1 1.2e-10 41.6 0.1 1.9 1 0 0 1 1 1 1 S1 RNA binding domain zf-CCHC_3 PF13917.6 PIK61047.1 - 0.00025 20.9 0.0 0.0007 19.5 0.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 PIK61047.1 - 0.0043 17.1 0.3 0.012 15.7 0.3 1.8 1 0 0 1 1 1 1 Zinc knuckle LYRIC PF15686.5 PIK61047.1 - 0.037 13.6 30.3 0.052 13.1 30.3 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Nup35_RRM PF05172.13 PIK61049.1 - 3.4e-15 55.8 0.2 1.1e-09 38.1 0.0 2.3 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 PIK61049.1 - 0.00078 19.4 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Troponin PF00992.20 PIK61052.1 - 0.099 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Troponin PKcGMP_CC PF16808.5 PIK61053.1 - 1e-05 25.3 14.2 0.017 15.0 0.8 3.7 1 1 2 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase Ig_3 PF13927.6 PIK61053.1 - 2.5e-05 24.8 3.9 0.00041 20.9 2.2 2.8 2 0 0 2 2 2 1 Immunoglobulin domain UPF0242 PF06785.11 PIK61053.1 - 0.00018 21.7 8.2 0.00031 20.9 8.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Ig_2 PF13895.6 PIK61053.1 - 0.0005 20.4 2.9 0.00074 19.8 1.6 1.9 2 0 0 2 2 2 1 Immunoglobulin domain bZIP_1 PF00170.21 PIK61053.1 - 0.0037 17.3 19.3 0.088 12.9 4.6 2.5 2 1 0 2 2 2 2 bZIP transcription factor Fez1 PF06818.15 PIK61053.1 - 0.017 15.6 18.4 0.034 14.6 18.4 1.6 1 0 0 1 1 1 0 Fez1 I-set PF07679.16 PIK61053.1 - 0.019 15.0 0.1 0.085 12.9 0.1 2.1 1 0 0 1 1 1 0 Immunoglobulin I-set domain Atg14 PF10186.9 PIK61053.1 - 0.023 13.8 11.0 0.034 13.2 11.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cep57_CLD PF14073.6 PIK61053.1 - 0.041 13.9 16.8 0.76 9.8 5.7 2.2 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 ig PF00047.25 PIK61053.1 - 0.049 13.8 3.1 0.72 10.1 2.5 2.8 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK61053.1 - 0.05 13.7 2.7 0.13 12.4 2.7 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF1876 PF08962.11 PIK61053.1 - 0.059 13.3 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1876) DUF4071 PF13281.6 PIK61053.1 - 0.064 12.3 3.5 0.38 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4071) Lebercilin PF15619.6 PIK61053.1 - 0.079 12.6 19.1 0.13 11.9 19.1 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Pox_EPC_I2-L1 PF12575.8 PIK61053.1 - 0.12 12.6 0.0 0.41 10.9 0.0 1.9 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF641 PF04859.12 PIK61053.1 - 0.13 12.6 15.2 2.3 8.6 13.9 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) MLTR_LBD PF17765.1 PIK61053.1 - 0.16 12.1 1.5 15 5.6 0.1 2.4 1 1 1 2 2 2 0 MmyB-like transcription regulator ligand binding domain NPV_P10 PF05531.12 PIK61053.1 - 0.27 11.7 3.8 5 7.7 0.6 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 PIK61053.1 - 0.37 9.6 17.8 0.6 8.9 17.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IL6 PF00489.17 PIK61053.1 - 0.59 9.7 6.7 0.99 8.9 6.7 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family DUF4566 PF15130.6 PIK61053.1 - 0.81 9.1 6.4 3.8 6.9 0.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4566) Orf78 PF06024.12 PIK61053.1 - 1.1 9.6 0.0 1.1 9.6 0.0 2.8 2 1 1 3 3 3 0 Orf78 (ac78) DUF5499 PF17603.2 PIK61053.1 - 3.2 8.4 7.4 2.6 8.7 1.7 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5499) V_ATPase_I PF01496.19 PIK61053.1 - 3.9 5.3 14.0 5.1 4.9 0.1 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Zip PF02535.22 PIK61053.1 - 8.2 5.5 8.1 76 2.4 8.1 2.1 1 1 0 1 1 1 0 ZIP Zinc transporter Seryl_tRNA_N PF02403.22 PIK61053.1 - 9.3 6.5 18.0 0.69 10.2 11.8 2.2 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain Ig_3 PF13927.6 PIK61054.1 - 1.3e-13 51.4 2.2 3.1e-07 30.9 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK61054.1 - 2.7e-11 43.5 0.5 8.3e-06 25.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK61054.1 - 1.1e-10 41.7 1.0 1.1e-08 35.2 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK61054.1 - 6.6e-09 35.7 0.2 5.3e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61054.1 - 9.2e-08 32.3 1.9 0.009 16.3 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 PIK61054.1 - 2.5e-05 24.5 1.4 0.00026 21.3 0.0 3.1 2 2 1 3 3 3 1 Immunoglobulin C1-set domain DUF4307 PF14155.6 PIK61054.1 - 0.011 15.6 1.5 0.016 15.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) Lep_receptor_Ig PF06328.11 PIK61054.1 - 0.052 13.5 6.0 0.19 11.7 0.1 3.6 3 1 0 3 3 3 0 Ig-like C2-type domain Izumo-Ig PF16706.5 PIK61054.1 - 0.073 13.1 0.2 3.6 7.7 0.0 2.6 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain DUF982 PF06169.12 PIK61055.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF982) Ig_3 PF13927.6 PIK61056.1 - 3.3e-11 43.6 10.1 0.0019 18.8 0.2 4.2 3 1 1 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 PIK61056.1 - 4.1e-11 43.1 8.0 1e-05 25.8 0.6 3.5 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK61056.1 - 5.3e-08 32.9 9.7 0.014 15.5 0.8 4.1 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK61056.1 - 5.4e-06 26.5 6.0 0.00017 21.7 0.0 3.6 3 2 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK61056.1 - 1.2e-05 25.3 3.6 0.77 9.9 0.1 3.8 3 1 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 PIK61056.1 - 0.0061 16.9 0.3 0.0061 16.9 0.3 3.0 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 PIK61056.1 - 0.0065 16.5 0.7 2.4 8.3 0.0 3.1 1 1 1 2 2 2 2 C17orf99 Ig domain Ig_6 PF18452.1 PIK61056.1 - 0.033 13.7 0.1 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK61057.1 - 7.8e-09 36.0 5.9 0.0016 19.0 0.0 3.3 3 1 1 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 PIK61057.1 - 2.2e-08 34.3 1.8 1.5e-05 25.2 0.4 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK61057.1 - 1.5e-07 31.6 3.6 1.6e-05 25.0 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 PIK61057.1 - 1.5e-07 31.4 1.6 0.02 15.1 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK61057.1 - 8.6e-07 29.0 0.5 0.0013 18.8 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain Lep_receptor_Ig PF06328.11 PIK61057.1 - 0.045 13.7 1.9 24 5.0 0.3 3.6 3 1 0 3 3 3 0 Ig-like C2-type domain TRAM_LAG1_CLN8 PF03798.16 PIK61058.1 - 4.8e-15 55.8 27.4 1.5e-14 54.2 27.3 1.9 1 1 0 1 1 1 1 TLC domain SHR3_chaperone PF08229.11 PIK61058.1 - 2.7 7.0 6.3 2.7 6.9 0.2 2.9 3 0 0 3 3 3 0 ER membrane protein SH3 Sel1 PF08238.12 PIK61059.1 - 0.00081 20.0 10.1 0.0022 18.6 0.8 3.9 4 0 0 4 4 4 2 Sel1 repeat Sel1 PF08238.12 PIK61060.1 - 1.2e-19 70.3 29.2 3.3e-05 24.4 1.4 7.5 7 0 0 7 7 7 5 Sel1 repeat OTU PF02338.19 PIK61060.1 - 2.9e-07 31.0 0.0 9.2e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 OTU-like cysteine protease TPR_17 PF13431.6 PIK61060.1 - 0.00053 20.2 0.4 0.16 12.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61060.1 - 0.028 15.1 4.2 0.039 14.6 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK61060.1 - 0.11 13.3 1.2 5.1 8.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61060.1 - 0.81 10.2 9.9 3.5 8.2 0.2 4.4 5 1 1 6 6 6 0 Tetratricopeptide repeat BRCA2 PF00634.18 PIK61063.1 - 0.04 13.6 0.0 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 BRCA2 repeat WTF PF03303.13 PIK61063.1 - 9.7 5.8 6.7 18 5.0 6.7 1.3 1 0 0 1 1 1 0 WTF protein BRCA-2_OB1 PF09103.10 PIK61064.1 - 4.1e-37 126.9 0.0 1.2e-36 125.3 0.0 1.9 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 PIK61064.1 - 2.4e-36 125.2 0.8 3.2e-32 111.7 0.0 3.3 3 1 1 4 4 4 2 BRCA2, helical BRCA-2_OB3 PF09104.10 PIK61064.1 - 7.2e-36 122.9 0.9 4.2e-35 120.4 0.2 2.3 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 Tower PF09121.10 PIK61064.1 - 1.4e-14 54.0 1.4 1.4e-14 54.0 1.4 2.6 2 0 0 2 2 2 1 Tower Homeodomain PF00046.29 PIK61065.1 - 2.8e-22 78.3 4.3 4.2e-22 77.8 4.3 1.3 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 PIK61065.1 - 0.018 14.9 0.2 0.028 14.3 0.2 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Homeobox_KN PF05920.11 PIK61065.1 - 0.026 14.4 0.2 0.053 13.4 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain HTH_23 PF13384.6 PIK61065.1 - 0.04 13.7 0.1 0.067 13.0 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Homeodomain PF00046.29 PIK61066.1 - 3.5e-22 78.0 6.1 6.4e-22 77.2 6.1 1.5 1 0 0 1 1 1 1 Homeodomain RAB3GAP2_N PF14655.6 PIK61066.1 - 0.17 11.1 0.8 2 7.6 0.1 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AMP-binding PF00501.28 PIK61068.1 - 1.2e-36 126.3 0.7 1.4e-32 112.8 0.0 2.6 2 1 1 3 3 3 2 AMP-binding enzyme FA_hydroxylase PF04116.13 PIK61068.1 - 4.8e-15 56.1 16.4 1.5e-14 54.4 16.4 1.9 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily PP-binding PF00550.25 PIK61068.1 - 0.028 14.8 0.1 0.064 13.6 0.1 1.7 1 0 0 1 1 1 0 Phosphopantetheine attachment site PQQ_3 PF13570.6 PIK61069.1 - 2e-36 123.5 0.0 4e-07 30.3 0.1 8.3 8 1 0 8 8 8 6 PQQ-like domain PQQ PF01011.21 PIK61069.1 - 1.3e-30 103.9 0.2 4.8e-06 26.2 0.0 8.3 8 0 0 8 8 8 6 PQQ enzyme repeat PQQ_2 PF13360.6 PIK61069.1 - 9.6e-26 90.8 0.0 2.8e-09 36.9 0.0 4.0 1 1 2 4 4 4 4 PQQ-like domain BBS1 PF14779.6 PIK61069.1 - 0.0012 18.3 0.1 2.9 7.3 0.0 3.3 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 1 WD40 PF00400.32 PIK61069.1 - 0.0037 18.1 5.1 1.1 10.3 0.1 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61069.1 - 0.009 16.3 0.0 5.2 7.5 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK61069.1 - 0.13 11.6 0.9 5 6.4 0.0 3.0 2 1 1 4 4 4 0 WD40-like domain AMOP PF03782.17 PIK61070.1 - 8.4e-26 90.8 1.6 1.7e-25 89.8 1.6 1.5 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK61070.1 - 3.1e-10 40.6 0.1 1.2e-09 38.7 0.0 2.0 2 1 0 2 2 2 1 von Willebrand factor type D domain Sushi PF00084.20 PIK61070.1 - 9.6e-06 26.1 0.7 2.7e-05 24.7 0.7 1.8 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) TMEM52 PF14979.6 PIK61070.1 - 0.00094 19.1 1.6 0.0017 18.3 1.6 1.3 1 0 0 1 1 1 1 Transmembrane 52 PAG PF15347.6 PIK61070.1 - 0.0012 17.9 0.5 0.011 14.7 0.6 2.1 2 0 0 2 2 2 1 Phosphoprotein associated with glycosphingolipid-enriched Shisa PF13908.6 PIK61070.1 - 0.0023 18.2 1.5 0.0025 18.1 0.1 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 PIK61070.1 - 0.025 14.5 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Nairovirus_M PF07948.11 PIK61070.1 - 0.027 12.7 0.3 0.046 12.0 0.3 1.3 1 0 0 1 1 1 0 Nairovirus M polyprotein-like Rax2 PF12768.7 PIK61070.1 - 0.072 12.5 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Cortical protein marker for cell polarity OSTbeta PF15048.6 PIK61070.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein MIT_C PF16565.5 PIK61071.1 - 4.9e-55 185.4 0.5 9.8e-55 184.4 0.5 1.5 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 PIK61071.1 - 3.3e-17 62.3 2.5 5.6e-17 61.6 2.5 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Lge1 PF11488.8 PIK61071.1 - 2.1 8.6 5.4 7 6.9 0.5 2.4 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 CAF1 PF04857.20 PIK61072.1 - 2e-21 76.5 1.8 4.8e-11 42.4 0.1 2.6 1 1 1 2 2 2 2 CAF1 family ribonuclease RNase_H_2 PF13482.6 PIK61072.1 - 0.0015 18.6 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 RNase_H superfamily Cadherin PF00028.17 PIK61073.1 - 2.8e-96 316.2 0.2 7.4e-23 80.8 0.3 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 PIK61073.1 - 1e-06 28.4 0.1 13 5.7 0.0 6.3 6 1 0 6 6 6 2 Cadherin-like RET_CLD1 PF17756.1 PIK61073.1 - 2.4e-05 24.6 0.0 1.4 9.2 0.0 4.0 4 0 0 4 4 4 2 RET Cadherin like domain 1 Cadherin_4 PF17803.1 PIK61073.1 - 3.5e-05 24.3 22.7 0.093 13.4 3.4 5.4 5 0 0 5 5 5 3 Bacterial cadherin-like domain Cadherin_3 PF16184.5 PIK61073.1 - 0.04 13.9 10.3 1.6 8.8 0.0 5.9 6 2 0 6 6 6 0 Cadherin-like Big_9 PF17963.1 PIK61073.1 - 0.066 14.0 24.0 0.063 14.0 6.3 5.0 5 0 0 5 5 5 0 Bacterial Ig domain DUF1845 PF08900.11 PIK61073.1 - 0.072 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) Invasin_D3 PF09134.10 PIK61073.1 - 1.5 9.2 5.8 19 5.6 1.2 3.5 3 1 0 3 3 3 0 Invasin, domain 3 Cadherin PF00028.17 PIK61074.1 - 1.4e-222 721.0 44.0 1.7e-24 86.1 0.5 13.2 13 0 0 13 13 13 13 Cadherin domain Cadherin_2 PF08266.12 PIK61074.1 - 1.4e-23 82.5 0.8 0.015 15.2 0.0 10.5 11 1 0 11 11 11 6 Cadherin-like Cadherin_C PF01049.17 PIK61074.1 - 2.8e-09 37.5 0.2 1.1e-08 35.6 0.0 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic region PepSY PF03413.19 PIK61074.1 - 0.00056 20.4 5.0 5.1 7.7 0.0 5.6 5 0 0 5 5 5 1 Peptidase propeptide and YPEB domain Y_Y_Y PF07495.13 PIK61074.1 - 0.011 15.6 1.4 1.1e+02 2.8 0.0 5.8 6 0 0 6 6 6 0 Y_Y_Y domain LRR_4 PF12799.7 PIK61075.1 - 2.5e-22 78.6 34.9 0.00031 21.1 0.2 10.9 7 3 3 11 11 11 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 PIK61075.1 - 2e-19 67.9 37.3 0.012 15.6 0.2 13.6 13 0 0 13 13 13 8 Leucine Rich repeat LRR_8 PF13855.6 PIK61075.1 - 1.2e-08 34.6 31.4 0.13 12.1 0.3 9.2 5 4 4 9 9 9 5 Leucine rich repeat LRR_1 PF00560.33 PIK61075.1 - 6.7e-08 32.0 32.0 6.4 7.7 0.0 12.2 12 2 0 12 12 12 2 Leucine Rich Repeat F-box_5 PF18511.1 PIK61075.1 - 0.00066 19.2 0.6 0.00066 19.2 0.6 1.8 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 PIK61075.1 - 0.00075 19.3 2.0 0.14 12.1 0.5 2.8 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 PIK61075.1 - 0.26 11.2 5.2 0.15 11.9 0.6 2.9 3 0 0 3 3 3 0 F-box domain AAA PF00004.29 PIK61076.1 - 1.3e-81 271.6 0.0 1.2e-39 135.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK61076.1 - 8.1e-24 83.2 4.7 1.5e-12 47.1 0.3 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 PIK61076.1 - 5.3e-07 29.9 0.0 0.016 15.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 PIK61076.1 - 5.4e-07 29.5 0.0 0.0062 16.3 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK61076.1 - 0.00018 22.0 1.2 0.093 13.1 0.0 3.7 2 2 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 PIK61076.1 - 0.00024 21.1 0.2 0.0029 17.6 0.0 2.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 PIK61076.1 - 0.00032 20.0 0.0 0.0026 17.0 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 PIK61076.1 - 0.0006 20.1 0.9 0.46 10.7 0.1 3.6 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.6 PIK61076.1 - 0.01 15.9 0.0 2.8 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 PIK61076.1 - 0.011 15.7 0.1 0.079 12.9 0.0 2.5 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_33 PF13671.6 PIK61076.1 - 0.043 14.0 0.0 2.4 8.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 PIK61076.1 - 0.062 13.7 0.0 2.1 8.8 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_3 PF07726.11 PIK61076.1 - 0.069 13.0 0.1 0.55 10.1 0.0 2.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 PIK61076.1 - 0.075 13.0 0.2 7.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain AAA_25 PF13481.6 PIK61076.1 - 0.33 10.5 1.6 11 5.5 0.1 2.8 3 1 0 3 3 3 0 AAA domain DUF719 PF05334.13 PIK61077.1 - 1.3e-39 136.4 0.4 1.3e-39 136.4 0.4 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF719) Acylphosphatase PF00708.18 PIK61077.1 - 0.081 13.3 0.6 0.34 11.3 0.6 2.0 1 0 0 1 1 1 0 Acylphosphatase DUF2155 PF09923.9 PIK61077.1 - 0.15 12.3 0.2 9.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2155) Nucleoporin_FG2 PF15967.5 PIK61078.1 - 2.5e-79 267.4 67.1 1.4e-78 264.9 3.9 2.6 2 1 0 2 2 2 2 Nucleoporin FG repeated region GCP_N_terminal PF17681.1 PIK61078.1 - 0.00088 19.0 1.1 0.0013 18.4 1.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal PHM7_cyt PF14703.6 PIK61078.1 - 0.0096 16.2 2.8 0.016 15.4 2.8 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Spectrin PF00435.21 PIK61078.1 - 0.043 14.3 4.4 0.15 12.5 2.3 2.3 2 1 0 2 2 2 0 Spectrin repeat DUF948 PF06103.11 PIK61078.1 - 0.063 13.5 1.1 3.4 8.0 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2383 PF09537.10 PIK61078.1 - 0.13 12.6 0.3 0.13 12.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) SKA1 PF07160.12 PIK61078.1 - 2.8 7.7 6.8 4.2 7.1 0.2 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Mod_r PF07200.13 PIK61078.1 - 5.9 7.0 9.8 2 8.5 3.2 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BBS2_Mid PF14783.6 PIK61079.1 - 7.8e-05 22.7 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region Itfg2 PF15907.5 PIK61079.1 - 0.04 13.0 0.0 0.62 9.0 0.0 2.1 1 1 2 3 3 3 0 Integrin-alpha FG-GAP repeat-containing protein 2 TPR_MLP1_2 PF07926.12 PIK61080.1 - 0.0042 17.1 11.3 0.0065 16.5 11.3 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF4164 PF13747.6 PIK61080.1 - 0.016 15.5 5.5 0.016 15.5 5.5 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4164) RR_TM4-6 PF06459.12 PIK61080.1 - 0.044 13.6 8.7 0.05 13.4 8.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1664 PF07889.12 PIK61080.1 - 0.21 11.6 5.1 0.1 12.6 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 PIK61080.1 - 0.23 11.7 18.2 0.5 10.6 18.2 1.5 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 OmpH PF03938.14 PIK61080.1 - 0.37 11.1 21.6 0.085 13.2 11.7 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 PIK61080.1 - 0.39 10.2 8.4 0.48 9.9 8.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF87 PF01935.17 PIK61080.1 - 0.43 10.6 6.4 0.49 10.4 6.4 1.0 1 0 0 1 1 1 0 Helicase HerA, central domain Seryl_tRNA_N PF02403.22 PIK61080.1 - 0.55 10.5 12.6 0.14 12.4 3.6 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FAM76 PF16046.5 PIK61080.1 - 0.77 9.0 11.9 1.1 8.6 11.9 1.2 1 0 0 1 1 1 0 FAM76 protein TORC_M PF12885.7 PIK61080.1 - 0.89 9.5 3.8 0.67 9.9 2.5 1.4 1 1 1 2 2 2 0 Transducer of regulated CREB activity middle domain DUF4407 PF14362.6 PIK61080.1 - 0.92 8.8 7.4 1.2 8.5 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 PIK61080.1 - 1.2 8.2 12.6 1.4 8.0 12.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tho2 PF11262.8 PIK61080.1 - 2 7.5 10.0 2.3 7.3 10.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 KfrA_N PF11740.8 PIK61080.1 - 2 9.1 6.9 0.38 11.5 1.6 2.0 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Fzo_mitofusin PF04799.13 PIK61080.1 - 2 7.9 6.2 3 7.3 6.1 1.4 1 1 0 1 1 1 0 fzo-like conserved region AAA_11 PF13086.6 PIK61080.1 - 2.2 8.0 9.5 2.7 7.7 9.5 1.1 1 0 0 1 1 1 0 AAA domain Ax_dynein_light PF10211.9 PIK61080.1 - 2.4 8.1 14.0 3.2 7.7 14.0 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Metal_resist PF13801.6 PIK61080.1 - 8.6 6.6 7.8 3.8 7.7 3.6 2.1 1 1 1 2 2 2 0 Heavy-metal resistance Septin PF00735.18 PIK61081.1 - 9.5e-09 34.9 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Septin Septin PF00735.18 PIK61082.1 - 3.1e-49 167.8 0.2 5.1e-49 167.1 0.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 PIK61082.1 - 9.1e-06 25.7 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 PIK61082.1 - 0.00056 20.3 0.2 0.012 15.9 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK61082.1 - 0.00081 19.7 0.0 0.0017 18.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain Roc PF08477.13 PIK61082.1 - 0.0039 17.4 0.4 0.0075 16.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 PIK61082.1 - 0.0072 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Microtub_bd PF16796.5 PIK61082.1 - 0.017 15.0 0.4 0.039 13.9 0.1 1.8 1 1 1 2 2 2 0 Microtubule binding AAA_7 PF12775.7 PIK61082.1 - 0.026 14.0 0.1 0.066 12.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Ras PF00071.22 PIK61082.1 - 0.028 14.0 0.0 0.07 12.7 0.0 1.7 1 1 0 1 1 1 0 Ras family RsgA_GTPase PF03193.16 PIK61082.1 - 0.054 13.4 0.1 0.12 12.3 0.1 1.6 1 1 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 PIK61082.1 - 2.1 8.8 6.0 0.23 12.0 0.3 2.1 1 1 1 2 2 2 0 ABC transporter Peptidase_S8 PF00082.22 PIK61083.1 - 3.7e-14 52.7 7.1 6.7e-14 51.8 7.1 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK61083.1 - 3.7e-06 27.5 0.0 9.7e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 TPP_enzyme_N PF02776.18 PIK61083.1 - 0.25 11.0 1.1 0.54 9.8 0.9 1.6 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Peptidase_S8 PF00082.22 PIK61084.1 - 8.6e-28 97.4 15.3 1.4e-27 96.7 15.3 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 PIK61084.1 - 6.7e-06 26.7 0.0 1.7e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 Ank_4 PF13637.6 PIK61086.1 - 3.6e-20 72.1 5.5 3.9e-10 40.1 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK61086.1 - 6.2e-18 65.2 1.0 9.7e-09 35.7 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK61086.1 - 1.6e-16 60.1 1.2 2.9e-07 30.6 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK61086.1 - 1.1e-15 57.3 3.1 6.1e-05 23.3 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 PIK61086.1 - 5.1e-13 47.9 2.6 0.0096 16.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 PIK61087.1 - 3.3e-35 120.0 15.6 3.3e-09 37.1 0.1 6.7 3 1 5 8 8 8 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK61087.1 - 3.4e-30 104.5 14.7 2.4e-15 56.9 1.0 4.8 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 PIK61087.1 - 2.1e-25 88.0 18.9 7e-06 26.3 0.0 7.4 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 PIK61087.1 - 2.6e-23 79.5 9.8 3.4e-05 23.9 0.1 7.9 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 PIK61087.1 - 1e-21 76.7 12.8 3.8e-06 27.1 0.2 6.9 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ion_trans PF00520.31 PIK61087.1 - 5.7e-12 45.4 20.6 8.7e-12 44.8 20.6 1.2 1 0 0 1 1 1 1 Ion transport protein UCR_UQCRX_QCR9 PF05365.12 PIK61087.1 - 0.79 9.7 2.9 5.5 7.0 2.7 2.4 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Paf67 PF10255.9 PIK61088.1 - 5.6e-98 328.6 7.1 1.1e-55 189.3 0.1 2.1 1 1 1 2 2 2 2 RNA polymerase I-associated factor PAF67 DUF2428 PF10350.9 PIK61088.1 - 0.0094 15.2 0.0 4.9 6.3 0.0 2.5 1 1 1 2 2 2 2 Putative death-receptor fusion protein (DUF2428) HLH PF00010.26 PIK61090.1 - 3.2e-15 55.8 1.5 3.2e-15 55.8 1.5 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.21 PIK61091.1 - 3.9e-34 118.2 17.7 5.8e-34 117.6 17.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 PIK61091.1 - 0.59 10.5 6.0 2.4 8.5 0.1 3.0 3 0 0 3 3 3 0 Orf78 (ac78) Gaa1 PF04114.14 PIK61091.1 - 2.9 6.8 12.9 3 6.8 3.9 2.5 1 1 1 2 2 2 0 Gaa1-like, GPI transamidase component EF-hand_7 PF13499.6 PIK61092.1 - 0.00013 22.3 4.7 0.00029 21.2 3.2 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK61092.1 - 0.0014 18.0 4.8 0.1 12.2 0.4 3.1 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 PIK61092.1 - 0.0018 17.7 0.3 0.0018 17.7 0.3 3.0 3 1 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 PIK61092.1 - 0.0084 16.0 5.0 0.96 9.5 0.1 3.1 3 1 1 4 4 4 2 EF-hand domain DUF325 PF03804.13 PIK61092.1 - 0.023 14.7 0.0 0.043 13.9 0.0 1.4 1 1 0 1 1 1 0 Viral proteins of unknown function EF-hand_8 PF13833.6 PIK61092.1 - 0.76 9.7 4.3 0.86 9.5 0.2 2.7 4 0 0 4 4 4 0 EF-hand domain pair Ly49 PF08391.10 PIK61094.1 - 0.01 16.2 0.1 0.012 16.0 0.1 1.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region EF-hand_5 PF13202.6 PIK61095.1 - 0.0077 15.7 3.2 0.018 14.5 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 PIK61095.1 - 0.052 14.0 0.9 0.16 12.4 0.9 1.8 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 PIK61095.1 - 0.075 12.6 2.6 0.45 10.2 0.2 2.2 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 PIK61095.1 - 0.1 12.6 3.1 0.28 11.2 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 PIK61096.1 - 4.9e-09 35.1 1.9 0.00052 19.4 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 PIK61096.1 - 6.5e-08 32.9 0.9 1.8e-07 31.5 0.9 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK61096.1 - 2.1e-07 30.3 1.4 0.00088 19.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 PIK61096.1 - 2.3e-05 23.7 2.8 0.022 14.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 PIK61096.1 - 7.6e-05 22.5 1.5 0.039 13.8 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK61096.1 - 0.029 14.7 0.1 0.054 13.8 0.1 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2996 PF11210.8 PIK61096.1 - 0.11 13.0 0.2 0.18 12.3 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2996) RCR PF12273.8 PIK61096.1 - 1.5 9.5 2.8 3.5 8.3 2.8 1.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red F5_F8_type_C PF00754.25 PIK61097.1 - 0.0024 18.0 0.1 0.0056 16.8 0.1 1.6 1 0 0 1 1 1 1 F5/8 type C domain DUF945 PF06097.11 PIK61098.1 - 0.017 14.3 0.7 0.029 13.5 0.2 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF945) Bactofilin PF04519.13 PIK61098.1 - 0.03 14.6 2.5 0.38 11.1 0.1 3.6 3 2 0 3 3 3 0 Polymer-forming cytoskeletal hGDE_N PF14699.6 PIK61098.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain from the human glycogen debranching enzyme DUF1491 PF07372.12 PIK61102.1 - 0.00072 19.9 0.0 3 8.3 0.0 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1491) ChlamPMP_M PF07548.11 PIK61103.1 - 0.079 12.9 0.7 14 5.6 0.0 3.5 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein middle domain EGF_2 PF07974.13 PIK61109.1 - 2e-28 98.4 311.1 1.2e-05 25.6 4.0 21.0 20 1 1 21 21 21 16 EGF-like domain EGF_Tenascin PF18720.1 PIK61109.1 - 0.0063 16.5 8.7 0.0063 16.5 8.7 16.3 13 4 5 18 18 18 6 Tenascin EGF domain EGF_2 PF07974.13 PIK61110.1 - 0.0021 18.4 22.6 0.0085 16.4 10.1 6.6 6 1 0 6 6 6 5 EGF-like domain EGF_2 PF07974.13 PIK61111.1 - 8.5e-10 38.8 67.3 0.0002 21.7 8.7 5.4 5 0 0 5 5 5 4 EGF-like domain EGF_Tenascin PF18720.1 PIK61111.1 - 3.1e-05 23.9 24.6 6e-05 23.0 17.0 5.4 4 1 1 5 5 5 3 Tenascin EGF domain EGF PF00008.27 PIK61111.1 - 0.00057 20.1 52.9 0.003 17.8 3.6 5.4 3 1 2 5 5 5 4 EGF-like domain Laminin_EGF PF00053.24 PIK61111.1 - 6.9 6.9 55.2 0.52 10.5 7.7 5.2 1 1 4 5 5 5 0 Laminin EGF domain VWD PF00094.25 PIK61112.1 - 4.5e-14 53.0 0.3 2.4e-10 40.9 0.2 2.9 2 0 0 2 2 2 2 von Willebrand factor type D domain Laminin_G_3 PF13385.6 PIK61112.1 - 1.5e-12 48.0 11.0 3.5e-07 30.5 0.8 3.7 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 PIK61112.1 - 0.0012 19.1 7.6 0.0012 19.1 7.6 8.4 8 1 1 9 9 9 1 EGF-like domain VWD PF00094.25 PIK61113.1 - 0.0081 16.4 0.1 0.097 12.9 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type D domain Laminin_EGF PF00053.24 PIK61113.1 - 0.29 11.3 23.5 0.51 10.5 5.4 2.9 1 1 1 2 2 2 0 Laminin EGF domain EGF_2 PF07974.13 PIK61113.1 - 1.6 9.2 35.4 0.18 12.2 9.8 3.8 2 1 1 3 3 3 0 EGF-like domain TPR_2 PF07719.17 PIK61114.1 - 7.1e-16 57.0 4.1 8.6e-06 25.5 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61114.1 - 2.3e-11 43.0 4.5 5e-05 22.9 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 PIK61114.1 - 3.4e-08 33.6 0.2 0.014 16.1 0.1 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61114.1 - 5.9e-08 32.3 3.0 0.042 14.1 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61114.1 - 1.1e-07 31.4 1.1 0.00016 21.3 0.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.6 PIK61114.1 - 8.2e-07 29.4 1.0 0.002 18.6 0.9 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61114.1 - 1.7e-05 25.4 0.1 0.19 12.4 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61114.1 - 1.9e-05 24.9 1.6 0.00026 21.2 0.1 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat DUF4003 PF13170.6 PIK61114.1 - 0.00096 18.6 1.2 0.0014 18.0 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4003) ANAPC3 PF12895.7 PIK61114.1 - 0.0012 19.0 1.6 0.0061 16.8 1.5 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 PIK61114.1 - 0.0024 18.0 0.0 0.29 11.3 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat RICTOR_N PF14664.6 PIK61114.1 - 0.0045 16.0 1.1 0.013 14.5 0.1 1.9 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term TPR_6 PF13174.6 PIK61114.1 - 0.0045 17.5 2.3 5 8.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 PIK61114.1 - 0.007 16.7 0.2 11 6.6 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF4919 PF16266.5 PIK61114.1 - 0.0078 16.2 1.1 0.38 10.7 0.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4919) Fis1_TPR_C PF14853.6 PIK61114.1 - 0.0083 16.2 0.9 5.2 7.2 0.0 3.8 2 1 2 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 PIK61114.1 - 0.015 14.6 0.5 1.9 7.6 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF5001 PF16392.5 PIK61114.1 - 0.016 15.1 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 Ig-like domain TPR_7 PF13176.6 PIK61114.1 - 0.024 14.7 0.5 1 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF908 PF06012.12 PIK61114.1 - 0.03 13.8 2.9 0.27 10.6 0.2 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF908) BTAD PF03704.17 PIK61114.1 - 0.037 14.5 1.7 0.45 10.9 1.7 2.5 1 1 0 1 1 1 0 Bacterial transcriptional activator domain DUF3361 PF11841.8 PIK61114.1 - 0.057 13.4 2.7 0.15 12.0 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) DUF3856 PF12968.7 PIK61114.1 - 0.11 12.6 1.4 18 5.4 1.4 3.2 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 PIK61114.1 - 0.18 12.2 3.8 0.76 10.2 0.2 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 PIK61114.1 - 0.53 10.4 4.0 0.57 10.3 1.8 2.3 2 0 0 2 2 1 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 PIK61114.1 - 0.53 9.8 2.2 7.3 6.1 0.0 2.7 3 0 0 3 3 2 0 SHNi-TPR UNC45-central PF11701.8 PIK61115.1 - 2e-21 76.6 2.8 5.2e-21 75.2 0.6 2.4 2 1 1 3 3 3 1 Myosin-binding striated muscle assembly central Arm PF00514.23 PIK61115.1 - 0.001 19.1 1.0 39 4.5 0.1 5.7 5 1 2 7 7 7 1 Armadillo/beta-catenin-like repeat V_ATPase_I_N PF18670.1 PIK61115.1 - 0.11 13.0 0.9 14 6.1 0.2 3.2 3 0 0 3 3 3 0 V-type ATPase subunit I, N-terminal domain Integrase_H2C2 PF17921.1 PIK61118.1 - 3.5e-17 62.3 2.8 4.1e-17 62.0 1.5 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK61118.1 - 3.4e-16 59.5 0.0 6e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK61118.1 - 0.0072 16.1 0.0 0.021 14.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 PIK61119.1 - 6.8e-38 128.7 0.0 1.2e-37 128.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK61119.1 - 1.1e-33 115.7 0.0 2.2e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 PIK61119.1 - 0.093 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Pao retrotransposon peptidase Myofilin PF15929.5 PIK61120.1 - 0.0016 18.9 0.3 0.0022 18.4 0.3 1.3 1 0 0 1 1 1 1 Myofilin DED PF01335.21 PIK61121.1 - 2.2e-11 43.9 1.8 2.2e-11 43.9 1.8 2.6 2 1 0 2 2 2 1 Death effector domain zf-B_box PF00643.24 PIK61121.1 - 4.1e-07 30.1 4.8 9.9e-07 28.8 4.8 1.6 1 0 0 1 1 1 1 B-box zinc finger TPR_MLP1_2 PF07926.12 PIK61121.1 - 0.44 10.6 12.8 0.11 12.5 1.2 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Glyco_transf_10 PF00852.19 PIK61122.1 - 7.7e-19 68.1 0.0 9.7e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK61122.1 - 4.1e-06 27.2 0.1 6.7e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal REJ PF02010.15 PIK61123.1 - 8.1e-24 84.2 0.2 9.9e-24 83.9 0.2 1.1 1 0 0 1 1 1 1 REJ domain Collectrin PF16959.5 PIK61123.1 - 0.088 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Renal amino acid transporter GPS PF01825.21 PIK61124.1 - 5e-05 23.8 2.1 0.00015 22.2 2.1 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TssO PF17561.2 PIK61124.1 - 0.034 14.2 0.5 0.19 11.8 0.1 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO REJ PF02010.15 PIK61125.1 - 8.7e-30 103.9 2.5 4.3e-17 62.0 0.0 2.1 1 1 1 2 2 2 2 REJ domain Big_5 PF13205.6 PIK61125.1 - 2.2 9.0 5.8 0.83 10.4 0.2 3.0 3 0 0 3 3 3 0 Bacterial Ig-like domain TFIIA PF03153.13 PIK61128.1 - 0.59 10.1 14.7 0.82 9.6 14.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF608 PF04685.13 PIK61130.1 - 5.5e-162 539.0 5.5 7.1e-162 538.6 5.5 1.1 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 PIK61130.1 - 2.6e-17 63.3 0.1 4.5e-17 62.5 0.1 1.3 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Bac_rhamnosid6H PF17389.2 PIK61130.1 - 0.00018 20.9 1.0 0.00032 20.1 1.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain GDE_C PF06202.14 PIK61130.1 - 0.0027 16.7 0.2 0.0062 15.5 0.2 1.6 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydr_116N PF12215.8 PIK61131.1 - 3.7e-72 243.4 0.4 4.8e-72 243.1 0.4 1.1 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term 7tm_1 PF00001.21 PIK61132.1 - 3.7e-32 111.7 13.2 4.3e-32 111.5 13.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK61132.1 - 1.1e-15 57.7 12.6 1.8e-15 57.0 12.6 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK61132.1 - 2.7e-11 43.6 16.0 2.7e-11 43.6 16.0 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 PIK61132.1 - 0.0014 18.2 6.8 0.0014 18.2 6.8 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 PIK61132.1 - 0.076 12.7 9.3 0.39 10.4 5.1 2.5 2 1 0 2 2 2 0 Olfactory receptor Peptidase_S49_N PF08496.10 PIK61132.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SBF PF01758.16 PIK61133.1 - 1.4e-35 122.8 14.5 2.2e-35 122.1 14.5 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family CrgA PF06781.12 PIK61133.1 - 0.63 10.1 7.1 1.5 8.9 0.1 3.3 2 1 1 3 3 3 0 Cell division protein CrgA GAPT PF11770.8 PIK61133.1 - 3.6 7.4 6.8 0.49 10.2 0.1 2.7 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) Gln-synt_C PF00120.24 PIK61134.1 - 4.5e-80 269.2 0.0 6.2e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 PIK61134.1 - 2.3e-05 24.0 0.1 0.0014 18.4 0.1 2.6 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain ThiF PF00899.21 PIK61135.1 - 1.2e-94 316.2 0.1 1.8e-63 214.1 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 PIK61135.1 - 2.6e-79 266.7 2.8 4.5e-79 265.9 2.8 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 PIK61135.1 - 1.5e-25 89.1 0.7 3.7e-25 87.9 0.7 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 PIK61135.1 - 5.4e-15 55.9 0.8 1.3e-14 54.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin fold domain E1_4HB PF16191.5 PIK61135.1 - 1.1e-12 48.0 0.0 1.3e-11 44.5 0.0 2.8 3 0 0 3 3 3 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 PIK61135.1 - 0.00042 20.4 0.6 0.0012 19.0 0.1 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 PIK61135.1 - 0.095 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 KR domain TrkA_N PF02254.18 PIK61135.1 - 0.098 12.9 0.1 0.42 10.9 0.1 2.2 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 PIK61135.1 - 0.17 12.4 0.9 20 5.8 0.2 3.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Ino80_Iec3 PF14612.6 PIK61135.1 - 0.34 11.5 1.7 0.63 10.7 0.5 2.0 2 0 0 2 2 2 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling 7tm_1 PF00001.21 PIK61136.1 - 8.1e-09 35.2 0.4 9.9e-09 34.9 0.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) C6_DPF PF10170.9 PIK61136.1 - 0.055 13.8 0.0 0.075 13.4 0.0 1.2 1 0 0 1 1 1 0 Cysteine-rich domain 7tm_1 PF00001.21 PIK61137.1 - 6.6e-15 55.2 7.1 8.3e-15 54.8 7.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 PIK61137.1 - 0.00064 19.6 7.0 0.00081 19.2 7.0 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 PIK61137.1 - 0.0054 16.1 8.4 0.0067 15.8 8.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2569 PF10754.9 PIK61137.1 - 0.041 14.3 4.7 0.064 13.7 4.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) HA2 PF04408.23 PIK61138.1 - 7.3e-19 68.0 0.2 2e-18 66.6 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 PIK61138.1 - 4e-13 49.7 0.2 8.4e-13 48.6 0.2 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 PIK61138.1 - 4.2e-12 46.3 0.0 1e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 PIK61138.1 - 5e-10 39.4 0.1 9.5e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase R3H PF01424.22 PIK61138.1 - 1.5e-08 34.5 0.0 3e-07 30.3 0.0 2.6 2 0 0 2 2 2 1 R3H domain Ank_5 PF13857.6 PIK61138.1 - 6.1e-06 26.4 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK61138.1 - 7.3e-06 26.5 0.1 2.1e-05 25.0 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) ATPase PF06745.13 PIK61138.1 - 0.0033 16.8 0.0 0.007 15.7 0.0 1.4 1 0 0 1 1 1 1 KaiC Ank PF00023.30 PIK61138.1 - 0.011 16.2 0.4 0.086 13.3 0.1 2.5 2 0 0 2 2 2 0 Ankyrin repeat AAA_23 PF13476.6 PIK61138.1 - 0.013 16.0 2.7 0.091 13.3 2.7 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 PIK61138.1 - 0.015 15.6 1.6 0.046 14.0 0.4 2.4 2 1 0 2 2 2 0 AAA domain Ank_3 PF13606.6 PIK61138.1 - 0.016 15.7 2.4 0.12 12.9 0.0 3.5 4 0 0 4 4 3 0 Ankyrin repeat AAA_19 PF13245.6 PIK61138.1 - 0.02 15.2 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 PIK61138.1 - 0.032 14.0 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 PIK61138.1 - 0.047 12.7 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 PIK61138.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 PIK61138.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Ank_4 PF13637.6 PIK61138.1 - 0.15 12.7 0.0 0.42 11.2 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Trypsin PF00089.26 PIK61139.1 - 1.2e-47 162.5 0.1 1.4e-47 162.3 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 PIK61139.1 - 0.00018 22.4 0.0 0.00029 21.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain ADP_PFK_GK PF04587.15 PIK61140.1 - 1e-120 403.2 0.0 1.2e-120 403.0 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region Sec1 PF00995.23 PIK61141.1 - 1.2e-129 434.2 1.7 1.4e-129 434.0 1.7 1.0 1 0 0 1 1 1 1 Sec1 family TNF PF00229.18 PIK61141.1 - 0.029 14.3 0.0 0.087 12.8 0.0 1.8 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family 4HB_MCP_1 PF12729.7 PIK61141.1 - 0.11 12.0 2.2 0.82 9.2 0.3 2.6 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction UvrD_C PF13361.6 PIK61141.1 - 0.29 10.5 3.2 0.44 9.9 3.0 1.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Aldose_epim PF01263.20 PIK61142.1 - 5.1e-39 134.4 0.3 6e-39 134.1 0.3 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Integrin_alpha2 PF08441.12 PIK61142.1 - 0.012 14.5 0.1 0.016 14.1 0.1 1.1 1 0 0 1 1 1 0 Integrin alpha DUF4432 PF14486.6 PIK61142.1 - 0.016 14.0 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) PHR PF08005.12 PIK61143.1 - 4.1e-47 160.6 0.1 5e-47 160.4 0.1 1.1 1 0 0 1 1 1 1 PHR domain DUF4082 PF13313.6 PIK61143.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) Pkinase_Tyr PF07714.17 PIK61144.1 - 3.3e-75 252.7 0.0 4.7e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61144.1 - 1.5e-33 116.3 0.0 2.1e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain XPA_C PF05181.12 PIK61145.1 - 4.4e-26 90.6 1.4 1.1e-25 89.4 1.4 1.7 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 PIK61145.1 - 1e-10 41.5 8.4 1e-10 41.5 8.4 2.0 2 0 0 2 2 2 1 XPA protein N-terminal zf-C4pol PF14260.6 PIK61145.1 - 0.087 13.3 0.5 0.087 13.3 0.5 2.6 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Zn-ribbon_8 PF09723.10 PIK61145.1 - 6.3 7.0 8.3 3.4 7.9 1.9 2.4 2 0 0 2 2 2 0 Zinc ribbon domain DUF2634 PF10934.8 PIK61146.1 - 0.4 10.8 7.7 0.095 12.8 2.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) DUF2353 PF09789.9 PIK61147.1 - 0.0044 16.4 29.0 0.0044 16.4 29.0 3.7 1 1 2 3 3 3 1 Uncharacterized coiled-coil protein (DUF2353) FlaC_arch PF05377.11 PIK61147.1 - 0.0085 16.5 1.0 0.0085 16.5 1.0 5.8 4 2 0 5 5 5 2 Flagella accessory protein C (FlaC) Filament PF00038.21 PIK61147.1 - 0.39 10.3 58.6 0.021 14.4 17.5 4.2 1 1 2 4 4 4 0 Intermediate filament protein DUF641 PF04859.12 PIK61147.1 - 1.1 9.6 52.5 0.14 12.5 6.8 4.3 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) ERM PF00769.19 PIK61147.1 - 5.5 6.7 73.4 0.82 9.4 30.1 2.4 1 1 2 3 3 3 0 Ezrin/radixin/moesin family GAS PF13851.6 PIK61148.1 - 0.0088 15.4 38.5 0.44 9.9 11.5 4.5 3 1 1 4 4 4 4 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 PIK61149.1 - 0.0065 16.0 30.6 0.1 12.1 7.9 2.6 1 1 1 2 2 2 2 Golgin subfamily A member 5 NIBRIN_BRCT_II PF16508.5 PIK61149.1 - 0.39 11.1 3.2 0.23 11.8 0.2 2.1 3 0 0 3 3 3 0 Second BRCT domain on Nijmegen syndrome breakage protein Baculo_PEP_C PF04513.12 PIK61149.1 - 0.46 10.5 3.0 32 4.5 0.1 3.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 PIK61149.1 - 0.53 9.1 24.3 0.092 11.6 4.7 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF489 PF04356.12 PIK61149.1 - 4.4 7.3 12.7 1.2 9.1 2.7 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF489) DUF948 PF06103.11 PIK61149.1 - 6 7.2 6.2 23 5.3 0.0 4.0 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 PIK61149.1 - 8.2 6.5 16.1 2.4 8.2 3.7 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TMEM223 PF14640.6 PIK61150.1 - 0.00016 21.9 0.1 0.00018 21.7 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 223 ubiquitin PF00240.23 PIK61151.1 - 2.4e-07 30.4 0.0 5.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 PIK61151.1 - 3.9e-05 23.5 0.1 0.00011 22.0 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_5 PF18037.1 PIK61151.1 - 0.00055 20.3 0.0 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 PIK61151.1 - 0.023 14.5 0.0 0.069 13.0 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like GNT-I PF03071.15 PIK61152.1 - 1.4e-104 350.3 0.2 1.8e-104 349.9 0.2 1.1 1 0 0 1 1 1 1 GNT-I family Glyco_tranf_2_3 PF13641.6 PIK61152.1 - 1.2e-05 25.4 0.0 2.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 PIK61152.1 - 0.00092 19.1 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 NIF PF03031.18 PIK61153.1 - 9e-55 184.7 1.1 1.3e-54 184.2 1.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RVT_1 PF00078.27 PIK61154.1 - 5.1e-41 140.6 0.1 8.6e-41 139.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Clat_adaptor_s PF01217.20 PIK61155.1 - 1.3e-18 67.3 1.2 1.7e-18 66.9 1.2 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Clat_adaptor_s PF01217.20 PIK61156.1 - 1.8e-09 37.7 0.1 2e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Collagen PF01391.18 PIK61158.1 - 1.6e-21 75.8 75.0 5.9e-09 35.6 18.5 3.2 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Orai-1 PF07856.12 PIK61159.1 - 6.2e-38 130.2 0.2 8.3e-38 129.8 0.2 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity Neurensin PF14927.6 PIK61159.1 - 0.057 13.1 0.4 0.099 12.3 0.3 1.3 1 1 0 1 1 1 0 Neurensin DUF1129 PF06570.11 PIK61159.1 - 0.12 11.9 0.0 0.12 11.9 0.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) PHD_4 PF16866.5 PIK61160.1 - 7e-18 64.5 9.0 7e-18 64.5 9.0 2.8 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.20 PIK61160.1 - 2.4e-13 49.9 23.0 2.4e-13 49.9 23.0 2.6 2 1 0 2 2 2 1 CXXC zinc finger domain Cupin_8 PF13621.6 PIK61160.1 - 9.9e-07 28.7 0.1 9.9e-07 28.7 0.1 3.2 2 2 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 PIK61160.1 - 2.5e-06 27.9 0.3 0.00018 21.9 0.3 3.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase JHD PF17811.1 PIK61160.1 - 5.7e-06 26.8 0.2 5.7e-06 26.8 0.2 2.1 2 0 0 2 2 2 1 Jumonji helical domain PHD PF00628.29 PIK61160.1 - 5.8e-05 22.9 7.7 5.8e-05 22.9 7.7 2.8 2 0 0 2 2 2 1 PHD-finger Cupin_1 PF00190.22 PIK61160.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Cupin Macoilin PF09726.9 PIK61160.1 - 0.94 7.9 13.3 1.5 7.3 13.3 1.2 1 0 0 1 1 1 0 Macoilin family LRR_6 PF13516.6 PIK61161.1 - 4e-08 32.7 11.3 0.009 16.0 0.3 5.6 6 0 0 6 6 6 3 Leucine Rich repeat F-box-like PF12937.7 PIK61161.1 - 3.7e-07 29.9 0.3 9.2e-07 28.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 PIK61161.1 - 4.4e-06 26.9 7.4 0.96 10.0 0.2 5.0 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK61161.1 - 3.2e-05 23.9 3.7 21 6.2 0.0 6.2 5 2 0 5 5 5 1 Leucine Rich Repeat F-box PF00646.33 PIK61161.1 - 0.0003 20.6 0.1 0.0011 18.8 0.1 2.1 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 PIK61161.1 - 0.00042 20.0 3.9 0.016 14.9 1.0 3.1 2 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.6 PIK61162.1 - 2.4e-07 30.3 11.6 0.013 15.5 0.3 5.4 5 0 0 5 5 5 3 Leucine Rich repeat F-box-like PF12937.7 PIK61162.1 - 4e-07 29.8 1.3 1e-06 28.5 1.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK61162.1 - 1.5e-05 24.7 0.1 4.6e-05 23.2 0.1 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 PIK61162.1 - 2.2e-05 24.7 7.5 1.4 9.4 0.3 4.9 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK61162.1 - 0.00029 21.0 4.2 32 5.6 0.0 6.0 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 PIK61162.1 - 0.001 18.8 3.8 0.025 14.3 1.0 2.9 2 1 0 2 2 2 1 Leucine rich repeat MORN PF02493.20 PIK61163.1 - 8.6e-29 97.7 35.8 7e-05 22.5 1.4 7.3 7 0 0 7 7 7 6 MORN repeat HlyD_D23 PF16576.5 PIK61164.1 - 0.67 9.1 4.4 1.1 8.4 4.4 1.2 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Coiled-coil_56 PF09813.9 PIK61164.1 - 4.4 7.4 7.8 11 6.1 7.8 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Tcp10_C PF07202.13 PIK61165.1 - 1.6e-83 278.9 3.0 1.6e-83 278.9 3.0 2.5 2 1 1 3 3 3 1 T-complex protein 10 C-terminus MORN_2 PF07661.13 PIK61165.1 - 0.0037 17.3 0.0 57 4.4 0.0 5.6 5 0 0 5 5 5 0 MORN repeat variant DUF4520 PF15016.6 PIK61165.1 - 0.025 14.7 0.0 3 8.0 0.0 3.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4520) Shugoshin_N PF07558.11 PIK61165.1 - 0.086 12.7 3.6 1.5 8.7 0.1 2.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region STIL_N PF15253.6 PIK61165.1 - 0.25 10.3 2.7 0.51 9.2 2.7 1.5 1 0 0 1 1 1 0 SCL-interrupting locus protein N-terminus CENP-K PF11802.8 PIK61165.1 - 3.9 7.0 24.9 8.3 5.9 24.9 1.5 1 1 0 1 1 1 0 Centromere-associated protein K RHS_repeat PF05593.14 PIK61165.1 - 4.7 7.8 6.1 9.3 6.9 0.6 3.5 4 0 0 4 4 4 0 RHS Repeat TSC22 PF01166.18 PIK61165.1 - 7.7 6.9 12.2 66 3.9 0.4 3.6 2 1 0 2 2 2 0 TSC-22/dip/bun family INTS2 PF14750.6 PIK61167.1 - 2.4e-258 859.8 5.0 2.6e-258 859.6 5.0 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 INTS2 PF14750.6 PIK61168.1 - 9.2e-94 314.9 0.4 1.1e-93 314.6 0.4 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 UQ_con PF00179.26 PIK61169.1 - 5.7e-47 158.9 0.0 7.5e-47 158.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PAW PF04721.17 PIK61170.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW MAM33 PF02330.16 PIK61171.1 - 1.6e-23 83.8 3.0 2.2e-23 83.3 3.0 1.2 1 0 0 1 1 1 1 Mitochondrial glycoprotein CAMSAP_CC1 PF17095.5 PIK61172.1 - 3.2e-18 65.3 2.0 9.4e-18 63.8 2.0 1.8 1 0 0 1 1 1 1 Spectrin-binding region of Ca2+-Calmodulin DUF1835 PF08874.10 PIK61173.1 - 0.54 10.5 0.1 0.54 10.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1835) CAMSAP_CKK PF08683.11 PIK61174.1 - 1.2e-49 167.4 0.0 1.4e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated DUF4250 PF14056.6 PIK61174.1 - 0.04 13.9 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) MIR PF02815.19 PIK61175.1 - 4.6e-14 52.7 1.1 2.5e-11 43.8 0.4 2.3 1 1 1 2 2 2 2 MIR domain RicinB_lectin_2 PF14200.6 PIK61175.1 - 0.0056 17.4 0.4 0.53 11.0 0.0 2.3 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ribosomal_L5 PF00281.19 PIK61176.1 - 2.2e-21 75.9 0.1 7.2e-20 71.1 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 PIK61176.1 - 8.1e-10 38.8 0.0 1.7e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus NYD-SP28 PF14772.6 PIK61177.1 - 9.3e-28 96.3 11.4 9.3e-28 96.3 11.4 4.7 2 1 1 4 4 4 1 Sperm tail Mga PF05043.13 PIK61177.1 - 0.2 12.3 11.2 0.7 10.5 5.9 3.2 2 1 0 2 2 2 0 Mga helix-turn-helix domain IBR PF01485.21 PIK61178.1 - 3e-12 46.6 24.6 2.6e-08 34.0 6.2 2.6 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain IBR PF01485.21 PIK61179.1 - 2.6e-14 53.2 12.5 2.6e-14 53.2 12.5 4.0 3 1 1 4 4 4 1 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 PIK61179.1 - 1.6e-05 24.7 9.0 1.6e-05 24.7 9.0 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK61179.1 - 8.3e-05 22.8 7.9 8.3e-05 22.8 7.9 3.6 3 1 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK61179.1 - 0.012 15.6 7.1 0.012 15.6 7.1 3.7 3 1 0 3 3 3 0 zinc-RING finger domain LRAT PF04970.13 PIK61180.1 - 3.8e-17 62.8 1.6 3.6e-11 43.5 0.2 3.1 2 1 0 2 2 2 2 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK61180.1 - 0.027 14.3 0.1 3.3 7.5 0.0 2.6 2 0 0 2 2 2 0 PPPDE putative peptidase domain CHAP PF05257.16 PIK61180.1 - 0.076 13.6 0.0 0.22 12.1 0.0 1.8 1 0 0 1 1 1 0 CHAP domain Mntp PF02659.15 PIK61180.1 - 0.11 12.3 9.0 0.21 11.3 9.0 1.4 1 0 0 1 1 1 0 Putative manganese efflux pump PHD PF00628.29 PIK61181.1 - 0.11 12.5 6.6 1 9.3 5.5 2.9 2 1 0 2 2 2 0 PHD-finger RVT_1 PF00078.27 PIK61182.1 - 3.8e-17 62.5 0.0 4.2e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRAT PF04970.13 PIK61183.1 - 5.8e-16 59.0 1.8 1.5e-10 41.4 0.2 3.2 2 1 0 2 2 2 2 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 PIK61183.1 - 0.032 14.1 0.1 4.9 7.0 0.0 2.7 2 0 0 2 2 2 0 PPPDE putative peptidase domain Mntp PF02659.15 PIK61183.1 - 0.037 13.8 6.5 0.069 12.9 6.5 1.4 1 0 0 1 1 1 0 Putative manganese efflux pump CHAP PF05257.16 PIK61183.1 - 0.078 13.6 0.0 0.21 12.2 0.0 1.7 1 0 0 1 1 1 0 CHAP domain 7tm_1 PF00001.21 PIK61184.1 - 1.2e-35 123.2 8.9 1.5e-35 122.9 8.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 PIK61184.1 - 0.025 13.9 7.6 0.055 12.8 7.4 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw MFS_1 PF07690.16 PIK61186.1 - 5.5e-10 38.7 18.8 2.2e-05 23.6 0.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Polysacc_synt_4 PF04669.13 PIK61187.1 - 5.7e-10 39.1 0.0 5.2e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Death PF00531.22 PIK61188.1 - 4.8e-07 29.8 0.4 1.6e-06 28.1 0.4 1.9 1 0 0 1 1 1 1 Death domain Pirin PF02678.16 PIK61189.1 - 9.5e-35 118.9 0.1 1.8e-34 118.0 0.1 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 PIK61189.1 - 3.9e-20 72.2 0.0 8.3e-19 67.9 0.0 2.5 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 PIK61189.1 - 1.9e-05 24.3 3.4 0.19 11.5 0.7 3.1 3 0 0 3 3 3 2 Cupin domain AraC_binding PF02311.19 PIK61189.1 - 0.013 15.4 0.3 5.8 6.8 0.0 2.2 2 0 0 2 2 2 0 AraC-like ligand binding domain Cupin_3 PF05899.12 PIK61189.1 - 0.13 11.9 0.6 15 5.4 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF861) Pkinase_Tyr PF07714.17 PIK61190.1 - 2.8e-39 135.0 0.0 4.1e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61190.1 - 2.7e-24 85.9 0.0 4.2e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 PIK61190.1 - 7.3e-21 74.6 0.5 1.2e-11 45.0 1.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 PIK61190.1 - 3e-20 71.7 2.3 7.5e-06 26.2 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 PIK61190.1 - 1.3e-18 66.8 8.0 1.1e-07 32.0 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK61190.1 - 5e-16 58.9 1.6 1.8e-08 34.8 0.2 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK61190.1 - 1.4e-14 52.7 1.0 0.0011 19.3 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Longin PF13774.6 PIK61191.1 - 3e-17 62.4 0.1 4.2e-17 62.0 0.1 1.2 1 0 0 1 1 1 1 Regulated-SNARE-like domain WD40_4 PF16300.5 PIK61192.1 - 5.1e-36 122.3 3.2 4.6e-17 61.6 0.5 2.6 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.32 PIK61192.1 - 1.4e-27 95.4 7.0 2.6e-05 24.9 0.0 9.1 8 1 0 8 8 8 4 WD domain, G-beta repeat DUF1899 PF08953.11 PIK61192.1 - 2.7e-26 91.2 0.5 6.4e-14 51.6 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 PIK61192.1 - 2.7e-14 53.2 0.0 6.3e-05 23.2 0.0 5.8 3 2 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK61192.1 - 5.6e-06 25.5 0.0 0.0015 17.6 0.0 3.3 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 PIK61192.1 - 7.9e-05 22.6 0.0 0.22 11.4 0.0 3.4 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 PIK61192.1 - 0.016 14.3 0.0 0.82 8.6 0.0 2.4 2 0 0 2 2 2 0 Coatomer WD associated region DUF1652 PF07865.11 PIK61192.1 - 0.15 11.9 0.0 3.2 7.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) DUF4805 PF16063.5 PIK61192.1 - 0.21 10.9 3.4 0.48 9.7 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) RabGAP-TBC PF00566.18 PIK61193.1 - 5.1e-35 121.1 14.5 8.8e-35 120.3 3.6 3.1 3 1 0 3 3 3 2 Rab-GTPase-TBC domain TAF PF02969.17 PIK61193.1 - 0.0091 16.1 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CCCAP PF15964.5 PIK61194.1 - 2.9e-08 32.5 24.0 2.9e-08 32.5 24.0 3.0 1 1 2 3 3 3 1 Centrosomal colon cancer autoantigen protein family Csm1_N PF18504.1 PIK61194.1 - 0.0054 17.0 2.2 0.0054 17.0 2.2 7.5 2 1 6 8 8 8 1 Csm1 N-terminal domain DUF883 PF05957.13 PIK61194.1 - 0.018 15.6 2.9 0.018 15.6 2.9 5.1 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF883) MTS PF05175.14 PIK61194.1 - 0.094 12.3 0.4 0.3 10.6 0.3 1.9 1 1 0 1 1 1 0 Methyltransferase small domain HALZ PF02183.18 PIK61194.1 - 0.14 12.4 0.4 0.14 12.4 0.4 7.6 8 0 0 8 8 8 0 Homeobox associated leucine zipper APG6_N PF17675.1 PIK61194.1 - 1.3 9.5 77.0 0.61 10.6 4.0 5.0 2 1 3 5 5 5 0 Apg6 coiled-coil region DUF3584 PF12128.8 PIK61195.1 - 0.91 7.0 44.9 1.2 6.5 44.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FAM184 PF15665.5 PIK61195.1 - 0.99 9.1 51.5 0.15 11.9 38.1 2.6 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B WXG100 PF06013.12 PIK61195.1 - 1.2 9.5 13.6 11 6.4 1.8 3.4 1 1 1 2 2 2 0 Proteins of 100 residues with WXG GAS PF13851.6 PIK61195.1 - 2.6 7.3 58.0 0.18 11.1 35.1 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding NHL PF01436.21 PIK61196.1 - 1.8e-45 150.8 20.5 5.4e-08 32.5 1.0 6.5 6 0 0 6 6 6 6 NHL repeat Filamin PF00630.19 PIK61196.1 - 1.1e-17 64.7 0.0 3.6e-17 63.1 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat SGL PF08450.12 PIK61196.1 - 3.6e-13 49.7 0.9 0.0007 19.3 0.1 5.1 1 1 3 4 4 4 4 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 PIK61196.1 - 4.3e-11 42.6 3.1 9.5e-06 25.0 0.1 4.1 1 1 1 3 3 3 3 6-bladed beta-propeller zf-B_box PF00643.24 PIK61196.1 - 1.3e-09 38.1 5.4 1.3e-09 38.1 5.4 2.9 3 1 0 3 3 1 1 B-box zinc finger zf-RING_UBOX PF13445.6 PIK61196.1 - 5.3e-09 36.0 9.9 1.8e-08 34.3 9.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK61196.1 - 1.7e-07 31.0 9.2 1.7e-07 31.0 9.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK61196.1 - 3e-07 30.2 10.4 3e-07 30.2 10.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK61196.1 - 4e-07 30.2 8.6 4e-07 30.2 8.6 3.1 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 PIK61196.1 - 1.3e-06 28.3 7.3 1.3e-06 28.3 7.3 2.5 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK61196.1 - 1.4e-05 24.9 6.3 1.4e-05 24.9 6.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK61196.1 - 0.00011 22.3 12.3 0.00011 22.3 12.3 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK61196.1 - 0.00015 21.5 8.9 0.00015 21.5 8.9 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Phytase-like PF13449.6 PIK61196.1 - 0.00031 20.8 0.0 11 5.9 0.0 4.7 2 2 2 4 4 4 0 Esterase-like activity of phytase Invasin_D3 PF09134.10 PIK61196.1 - 0.0011 19.2 0.0 0.0034 17.6 0.0 1.8 1 0 0 1 1 1 1 Invasin, domain 3 SBBP PF06739.11 PIK61196.1 - 0.011 15.7 1.1 3.8 7.6 0.0 3.0 2 0 0 2 2 2 0 Beta-propeller repeat zf-ANAPC11 PF12861.7 PIK61196.1 - 0.03 14.4 5.8 0.064 13.3 2.8 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF5011 PF16403.5 PIK61196.1 - 0.045 13.9 0.6 0.13 12.4 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) Exonuc_VII_L PF02601.15 PIK61196.1 - 0.35 10.4 2.3 0.53 9.8 2.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spectrin PF00435.21 PIK61196.1 - 0.36 11.3 2.9 0.72 10.4 2.9 1.5 1 0 0 1 1 1 0 Spectrin repeat Spc7 PF08317.11 PIK61196.1 - 0.48 9.3 9.4 0.71 8.7 9.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein VCBS PF13517.6 PIK61196.1 - 0.84 10.3 8.9 9.7 6.9 0.4 4.4 2 2 2 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-C4H2 PF10146.9 PIK61196.1 - 1.9 8.8 8.9 3.8 7.8 8.8 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein MFS_1_like PF12832.7 PIK61197.1 - 2e-38 132.2 0.0 2.5e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK61197.1 - 1.3e-06 27.6 4.7 1.3e-06 27.6 4.7 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily LacY_symp PF01306.19 PIK61197.1 - 8.1e-05 21.6 10.1 0.00039 19.3 0.1 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter zf-LITAF-like PF10601.9 PIK61197.1 - 7.5 6.9 13.1 6 7.2 1.5 3.6 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain MFS_1_like PF12832.7 PIK61198.1 - 3e-06 26.4 3.3 3.7e-06 26.1 3.3 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK61198.1 - 4.6e-06 25.8 0.1 5e-06 25.7 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 PIK61198.1 - 0.096 11.0 0.0 0.086 11.1 0.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BT1 PF03092.16 PIK61198.1 - 0.12 10.6 0.0 0.12 10.6 0.0 1.0 1 0 0 1 1 1 0 BT1 family MFS_1_like PF12832.7 PIK61199.1 - 6.7e-78 262.2 8.0 8.2e-78 261.9 8.0 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK61199.1 - 3.6e-16 59.0 29.1 5.3e-10 38.7 15.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 PIK61199.1 - 1.4e-08 34.2 13.4 2.4e-08 33.4 7.5 2.1 2 0 0 2 2 2 2 Nucleoside H+ symporter LacY_symp PF01306.19 PIK61199.1 - 2.7e-05 23.2 16.7 0.00064 18.6 2.1 2.5 2 1 0 2 2 2 2 LacY proton/sugar symporter AIF_C PF14721.6 PIK61200.1 - 7.5e-56 188.1 0.0 2.5e-55 186.4 0.0 1.9 1 1 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.14 PIK61200.1 - 5.6e-44 150.5 0.1 8.5e-44 149.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK61200.1 - 1.8e-13 50.8 0.7 5.6e-12 46.1 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 PIK61200.1 - 6.8e-05 22.9 3.9 0.15 12.0 0.3 4.0 3 1 1 4 4 4 2 FAD-NAD(P)-binding Amino_oxidase PF01593.24 PIK61200.1 - 0.00033 20.1 2.5 0.022 14.0 0.3 2.2 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase K_oxygenase PF13434.6 PIK61200.1 - 0.0014 17.8 0.1 0.014 14.5 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 PIK61200.1 - 0.026 14.1 8.8 1.9 8.0 0.2 3.6 2 2 1 3 3 3 0 FAD dependent oxidoreductase Reductase_C PF14759.6 PIK61200.1 - 0.074 13.6 0.0 0.25 11.9 0.0 1.9 1 0 0 1 1 1 0 Reductase C-terminal HI0933_like PF03486.14 PIK61200.1 - 1 8.0 3.9 13 4.4 0.0 2.9 3 1 1 4 4 4 0 HI0933-like protein Thioredoxin PF00085.20 PIK61201.1 - 9.5e-09 35.2 0.1 1.4e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 PIK61201.1 - 0.075 12.0 0.0 0.088 11.7 0.0 1.1 1 0 0 1 1 1 0 Phosducin TraF PF13728.6 PIK61201.1 - 0.076 12.8 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Abhydrolase_6 PF12697.7 PIK61202.1 - 1.4e-21 78.1 0.0 2.1e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 PIK61202.1 - 2.4e-10 40.1 0.0 4.7e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK61202.1 - 1.4e-07 31.4 0.1 9.7e-07 28.7 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 PIK61202.1 - 0.00028 20.7 0.0 0.00045 20.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 PIK61202.1 - 0.0014 18.8 0.0 0.002 18.3 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 PIK61202.1 - 0.0037 17.1 0.0 0.0066 16.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 PIK61202.1 - 0.0046 16.5 0.2 0.0078 15.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 PIK61202.1 - 0.014 15.2 0.1 0.032 14.0 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF676 PF05057.14 PIK61202.1 - 0.022 14.3 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Esterase PF00756.20 PIK61202.1 - 0.03 14.0 4.5 0.1 12.2 3.1 2.3 2 1 0 2 2 2 0 Putative esterase Ser_hydrolase PF06821.13 PIK61202.1 - 0.058 13.3 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase LCAT PF02450.15 PIK61202.1 - 0.06 12.5 0.3 0.2 10.8 0.0 1.8 1 1 0 2 2 2 0 Lecithin:cholesterol acyltransferase PGM_PMM_I PF02878.16 PIK61203.1 - 1.2e-37 128.7 0.1 3.5e-37 127.2 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 PIK61203.1 - 3e-24 85.6 0.0 7.6e-24 84.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 PIK61203.1 - 1.4e-12 47.8 0.3 2.7e-12 46.9 0.3 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 PIK61203.1 - 4.9e-05 23.4 0.0 0.00026 21.1 0.0 2.2 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF4434 PF14488.6 PIK61203.1 - 0.0049 16.9 0.2 3.6 7.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4434) Laminin_G_3 PF13385.6 PIK61204.1 - 0.00058 20.0 0.4 0.00087 19.5 0.4 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PP2C PF00481.21 PIK61205.1 - 5e-39 134.5 0.0 7.5e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK61205.1 - 4.5e-05 23.2 0.2 6.6e-05 22.6 0.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C GH3 PF03321.13 PIK61206.1 - 9.7e-143 476.8 0.0 1.1e-142 476.6 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter Fucokinase PF07959.12 PIK61207.1 - 1.9e-68 231.3 0.0 2.2e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase Fucokinase PF07959.12 PIK61208.1 - 3.9e-18 65.6 0.0 5.4e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase UbiA PF01040.18 PIK61209.1 - 1.1e-49 169.0 11.0 1.5e-49 168.6 11.0 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family SH3_9 PF14604.6 PIK61210.1 - 9.2e-36 121.5 0.2 1.2e-12 47.4 0.0 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 PIK61210.1 - 1.3e-33 114.3 0.6 3.8e-12 45.6 0.1 3.3 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 PIK61210.1 - 6.2e-31 105.9 1.1 7.8e-12 44.7 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain zf-C3HC4_2 PF13923.6 PIK61210.1 - 1.1e-09 38.0 8.3 2.1e-09 37.1 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK61210.1 - 5.3e-09 36.3 8.7 9.5e-09 35.5 8.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 PIK61210.1 - 1.3e-08 34.6 8.9 2.2e-08 33.8 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK61210.1 - 1.7e-08 34.2 6.7 2.7e-08 33.5 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK61210.1 - 4.1e-07 29.8 7.6 7.3e-07 29.0 7.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK61210.1 - 3.2e-06 27.1 7.4 3.9e-06 26.8 6.0 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 PIK61210.1 - 4e-06 26.5 6.1 1.2e-05 25.0 5.9 1.8 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 PIK61210.1 - 0.00012 22.1 7.8 0.00022 21.3 7.8 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK61210.1 - 0.00048 19.9 7.5 0.00089 19.1 7.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 PIK61210.1 - 0.0014 18.5 2.8 0.0027 17.6 2.8 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 PIK61210.1 - 0.0015 18.2 3.4 0.0015 18.2 3.4 2.1 1 1 1 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 PIK61210.1 - 0.014 15.7 4.5 0.03 14.6 4.5 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-P11 PF03854.14 PIK61210.1 - 0.069 12.8 6.1 0.16 11.7 6.1 1.6 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 PIK61210.1 - 0.12 12.4 4.2 0.37 10.8 4.2 1.8 1 1 0 1 1 1 0 Double zinc ribbon DUF1272 PF06906.11 PIK61210.1 - 0.27 11.3 6.0 0.56 10.3 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-MIZ PF02891.20 PIK61210.1 - 0.65 9.8 6.3 1.1 9.0 6.3 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zinc-ribbons_6 PF07191.12 PIK61210.1 - 0.85 9.6 4.6 1.6 8.8 4.6 1.4 1 0 0 1 1 1 0 zinc-ribbons Secretin_N_2 PF07655.13 PIK61210.1 - 3.2 8.4 7.6 13 6.4 7.6 2.1 1 1 0 1 1 1 0 Secretin N-terminal domain Ion_trans PF00520.31 PIK61211.1 - 4.9e-27 94.7 7.4 6.3e-27 94.4 7.4 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK61211.1 - 4.3e-07 29.0 8.0 2.9e-06 26.2 8.0 2.1 1 1 0 1 1 1 1 Polycystin cation channel MBT PF02820.18 PIK61212.1 - 2.5e-11 43.7 0.0 4.5e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 mbt repeat MBT PF02820.18 PIK61213.1 - 3.5e-65 216.3 3.9 1.3e-22 79.9 0.0 3.3 3 0 0 3 3 3 3 mbt repeat SR-25 PF10500.9 PIK61213.1 - 0.013 15.1 28.4 0.013 15.1 28.4 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2052 PF09747.9 PIK61213.1 - 0.17 12.0 6.3 0.29 11.2 6.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RSB_motif PF16294.5 PIK61213.1 - 0.45 10.8 23.1 0.96 9.7 0.3 2.4 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif Presenilin PF01080.17 PIK61213.1 - 2.1 7.1 7.1 2.7 6.7 7.1 1.2 1 0 0 1 1 1 0 Presenilin DUF3987 PF13148.6 PIK61213.1 - 2.3 7.2 5.6 3.4 6.6 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) EOS1 PF12326.8 PIK61213.1 - 3.9 7.4 6.2 12 5.8 6.2 1.7 1 1 0 1 1 1 0 N-glycosylation protein DUF1682 PF07946.14 PIK61213.1 - 6.6 5.8 14.8 11 5.1 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ureide_permease PF07168.11 PIK61213.1 - 7.9 5.1 5.1 13 4.5 5.1 1.2 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 PIK61213.1 - 9.5 5.3 6.6 17 4.5 6.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SAM_1 PF00536.30 PIK61214.1 - 0.026 15.0 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK61214.1 - 0.031 14.4 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 PIK61214.1 - 0.062 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 PIK61215.1 - 5.3e-69 232.5 0.1 1e-68 231.6 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61215.1 - 2.8e-46 157.9 0.0 5.2e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK61215.1 - 8.4e-05 22.0 0.0 8.4e-05 22.0 0.0 2.5 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 PIK61215.1 - 0.0011 17.9 9.2 0.023 13.5 0.0 3.0 3 0 0 3 3 3 2 Fungal protein kinase DUF4666 PF15697.5 PIK61215.1 - 0.01 16.5 1.5 0.01 16.5 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4666) APH PF01636.23 PIK61215.1 - 2.1 8.2 9.5 1.8 8.4 0.0 3.3 2 2 1 3 3 3 0 Phosphotransferase enzyme family CLCA PF08434.11 PIK61217.1 - 1.2e-48 165.7 0.1 1.5e-48 165.4 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Peptidase_M64 PF09471.10 PIK61217.1 - 0.13 11.8 2.0 0.22 11.0 1.1 1.7 1 1 1 2 2 2 0 IgA Peptidase M64 Big_3_3 PF13750.6 PIK61218.1 - 0.12 12.1 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) VWA PF00092.28 PIK61219.1 - 0.012 15.8 2.6 0.04 14.2 0.0 2.3 2 0 0 2 2 2 0 von Willebrand factor type A domain DUF4448 PF14610.6 PIK61219.1 - 0.014 15.1 0.3 0.051 13.3 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) PorB PF11565.8 PIK61219.1 - 0.061 13.7 0.5 0.23 11.9 0.0 2.1 2 0 0 2 2 2 0 Alpha helical Porin B TMEM154 PF15102.6 PIK61219.1 - 0.068 13.1 3.1 0.13 12.1 2.4 1.8 2 0 0 2 2 2 0 TMEM154 protein family Pox_F12L PF03337.13 PIK61220.1 - 0.025 12.7 0.1 2.7 6.0 0.0 2.1 2 0 0 2 2 2 0 Poxvirus F12L protein MG2 PF01835.19 PIK61220.1 - 0.045 14.2 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 MG2 domain CLCA PF08434.11 PIK61221.1 - 3.8e-26 92.0 0.0 4.5e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal PriA_3primeBD PF17764.1 PIK61221.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 3′ DNA-binding domain (3′BD) Pro_isomerase PF00160.21 PIK61222.1 - 6.2e-48 163.1 3.0 7.2e-48 162.8 2.2 1.5 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 PIK61222.1 - 6.7e-16 57.4 7.0 1.6e-05 24.5 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61222.1 - 3.9e-11 42.2 13.3 0.00034 20.5 0.8 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61222.1 - 1.2e-05 25.8 6.5 0.36 11.5 2.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61222.1 - 2.6e-05 24.1 8.7 0.11 12.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 PIK61222.1 - 0.00011 22.3 3.0 0.00021 21.3 1.5 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61222.1 - 0.00068 19.9 6.1 3.1 8.1 0.2 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61222.1 - 0.00082 19.8 10.4 0.0019 18.6 1.5 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61222.1 - 0.0013 18.4 1.6 0.053 13.2 0.0 3.2 2 1 1 3 3 3 1 TPR repeat TPR_6 PF13174.6 PIK61222.1 - 0.0023 18.4 5.0 8.7 7.2 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 PIK61222.1 - 0.014 16.1 6.1 1.5 9.8 1.4 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK61222.1 - 0.045 13.8 6.6 12 6.2 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK61222.1 - 0.055 13.4 3.9 7.3 6.6 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4623 PF15416.6 PIK61222.1 - 0.072 11.7 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4623) MIT PF04212.18 PIK61222.1 - 0.097 12.8 6.0 0.22 11.6 0.8 2.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 PIK61222.1 - 0.14 12.4 3.4 0.48 10.7 3.3 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 PIK61222.1 - 0.45 10.6 5.9 22 5.2 0.3 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 PIK61222.1 - 0.64 10.5 3.5 25 5.6 0.0 3.4 3 1 0 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.25 PIK61224.1 - 6.2e-53 179.8 0.0 3e-44 151.4 0.1 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61224.1 - 9.2e-27 93.9 0.0 7.4e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 PIK61224.1 - 0.00092 18.8 0.2 0.0014 18.3 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 PIK61224.1 - 0.0016 17.8 0.0 0.011 15.1 0.0 2.0 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 PIK61224.1 - 0.0026 17.4 0.1 0.72 9.4 0.0 2.2 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 PIK61224.1 - 0.0035 17.3 0.9 0.44 10.4 0.2 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 PIK61224.1 - 0.041 12.9 0.0 0.067 12.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 PIK61224.1 - 0.055 12.8 0.2 0.13 11.6 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.12 PIK61225.1 - 1.4e-05 25.6 4.8 2.8e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 Sel1 repeat DNA_pol_phi PF04931.13 PIK61228.1 - 9 4.3 7.5 12 3.8 7.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Myb_DNA-bind_7 PF15963.5 PIK61231.1 - 0.00051 19.9 0.2 0.00051 19.9 0.2 2.6 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 PIK61231.1 - 0.0031 17.6 0.6 0.076 13.2 0.0 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain RRN9 PF10680.9 PIK61231.1 - 0.054 13.8 1.6 0.28 11.5 1.6 2.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor Myb_DNA-bind_6 PF13921.6 PIK61231.1 - 0.15 12.4 1.0 32 4.9 0.0 3.3 4 0 0 4 4 4 0 Myb-like DNA-binding domain Sarcoglycan_1 PF04790.13 PIK61233.1 - 6.5e-25 88.0 2.8 7.6e-25 87.7 2.8 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein Sarcoglycan_1 PF04790.13 PIK61234.1 - 2.7e-28 99.0 0.0 3.5e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein Macoilin PF09726.9 PIK61235.1 - 9.3e-89 298.8 30.0 1.2e-88 298.4 30.0 1.1 1 0 0 1 1 1 1 Macoilin family Malic_M PF03949.15 PIK61235.1 - 0.036 13.3 1.0 0.07 12.4 1.0 1.4 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain DUF2935 PF11155.8 PIK61235.1 - 0.1 12.9 6.8 3.4 8.0 6.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) GLE1 PF07817.13 PIK61235.1 - 0.19 10.9 0.1 0.19 10.9 0.1 2.7 2 1 1 3 3 3 0 GLE1-like protein GAS PF13851.6 PIK61235.1 - 0.24 10.7 44.6 1.4 8.3 2.9 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding NFRKB_winged PF14465.6 PIK61235.1 - 0.97 9.7 4.5 0.83 9.9 1.7 2.3 1 1 1 2 2 2 0 NFRKB Winged Helix-like HALZ PF02183.18 PIK61235.1 - 7.6 6.8 15.9 0.14 12.4 0.8 3.8 4 1 0 4 4 4 0 Homeobox associated leucine zipper Pkinase PF00069.25 PIK61236.1 - 1.6e-105 352.2 0.0 6.4e-56 189.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61236.1 - 7e-54 182.8 0.0 2.3e-26 92.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK61236.1 - 9.1e-17 61.3 0.0 3.3e-07 29.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 PIK61236.1 - 3.4e-09 36.4 0.0 0.00019 20.8 0.0 2.6 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK61236.1 - 1e-08 34.4 0.0 0.00099 18.0 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Pkinase_C PF00433.24 PIK61236.1 - 3.8e-07 30.7 0.7 2.9e-06 27.9 1.5 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain APH PF01636.23 PIK61236.1 - 7.2e-05 22.8 0.0 0.29 11.0 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK61236.1 - 0.0019 17.2 0.2 0.72 8.7 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain FTA2 PF13095.6 PIK61236.1 - 0.028 14.1 0.1 2.1 7.9 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF1679 PF07914.11 PIK61236.1 - 0.038 12.8 0.0 0.06 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) YrbL-PhoP_reg PF10707.9 PIK61236.1 - 0.041 13.4 0.0 4.3 6.8 0.0 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 PIK61236.1 - 0.069 12.2 0.2 0.85 8.6 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 HisK_sensor PF18698.1 PIK61236.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase sensor domain Choline_kinase PF01633.20 PIK61236.1 - 0.14 11.7 0.1 5.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 PIK61236.1 - 0.14 11.7 0.9 0.3 10.7 0.2 1.8 2 0 0 2 2 2 0 RIO1 family RBD PF02196.15 PIK61237.1 - 0.095 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain RhoGEF PF00621.20 PIK61238.1 - 4.5e-20 72.6 1.1 4.5e-20 72.6 1.1 1.4 2 0 0 2 2 2 1 RhoGEF domain Serine_rich PF08824.10 PIK61238.1 - 0.026 14.6 0.1 0.048 13.7 0.1 1.5 1 1 0 1 1 1 0 Serine rich protein interaction domain HrpB2 PF09487.10 PIK61238.1 - 0.027 14.9 0.3 0.049 14.1 0.3 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) DUF3381 PF11861.8 PIK61238.1 - 0.049 13.4 0.8 0.11 12.3 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3381) Occludin_ELL PF07303.13 PIK61238.1 - 0.16 12.7 2.6 3.1 8.6 0.4 2.3 2 0 0 2 2 2 0 Occludin homology domain RhoGAP PF00620.27 PIK61239.1 - 7.6e-35 120.0 0.0 1.7e-34 118.9 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RA PF00788.23 PIK61239.1 - 8.9e-07 29.5 0.1 2.3e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nod1 PF17114.5 PIK61239.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 PH PF00169.29 PIK61239.1 - 0.065 13.8 1.2 0.14 12.6 0.1 2.2 3 0 0 3 3 3 0 PH domain Nudc_N PF14050.6 PIK61240.1 - 1.2e-15 57.2 0.3 5.6e-15 55.1 0.3 2.1 1 1 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 PIK61240.1 - 2.6e-14 54.0 0.8 2.6e-14 54.0 0.8 1.9 2 0 0 2 2 2 1 CS domain NuDC PF16273.5 PIK61240.1 - 2.9e-14 53.3 19.7 2.9e-14 53.3 19.7 3.2 2 2 1 3 3 3 1 Nuclear distribution C domain TAF4 PF05236.14 PIK61240.1 - 0.028 14.2 13.7 0.051 13.3 13.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Borrelia_P83 PF05262.11 PIK61240.1 - 0.17 10.3 16.2 0.24 9.8 16.2 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3987 PF13148.6 PIK61240.1 - 2.6 7.0 15.3 4.2 6.3 15.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RNAse_A_bac PF18431.1 PIK61240.1 - 2.9 8.9 6.9 14 6.7 6.0 2.2 2 0 0 2 2 2 0 Bacterial CdiA-CT RNAse A domain Ribosomal_S13 PF00416.22 PIK61240.1 - 4.4 7.7 6.6 0.98 9.8 2.3 2.0 2 1 0 2 2 2 0 Ribosomal protein S13/S18 ORC_WH_C PF18137.1 PIK61241.1 - 8.2e-22 77.8 0.3 4.9e-21 75.3 0.0 2.2 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 PIK61241.1 - 3.2e-21 75.8 6.7 8.1e-21 74.5 4.4 2.7 3 0 0 3 3 3 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC3_N PF07034.11 PIK61242.1 - 6.4e-41 140.5 0.0 8.2e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Clr5 PF14420.6 PIK61242.1 - 0.051 13.8 0.3 0.12 12.7 0.3 1.6 1 0 0 1 1 1 0 Clr5 domain RCC1 PF00415.18 PIK61243.1 - 4.1e-70 232.2 24.2 1.8e-13 50.9 0.1 8.7 6 2 1 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK61243.1 - 5.8e-33 112.0 20.8 1.2e-06 28.2 0.3 8.4 8 1 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 PIK61243.1 - 0.38 10.8 8.4 5.6 7.1 0.1 4.6 4 0 0 4 4 4 0 Galactose oxidase, central domain PID PF00640.23 PIK61245.1 - 4.9e-09 36.3 0.1 1e-08 35.3 0.1 1.5 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 PIK61245.1 - 6.6e-08 32.6 0.0 1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 PIK61245.1 - 0.00013 22.1 0.1 0.00026 21.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Ndc80_HEC PF03801.13 PIK61246.1 - 2.8e-37 127.7 0.7 8.1e-37 126.2 0.7 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 PIK61246.1 - 3.8e-10 39.7 7.4 3.8e-10 39.7 7.4 5.7 4 2 4 8 8 8 1 Domain of unknown function (DUF5595) Herpes_UL36 PF03586.13 PIK61246.1 - 0.0067 15.8 1.7 0.017 14.5 0.1 2.3 2 0 0 2 2 2 1 Herpesvirus UL36 tegument protein Nuf2 PF03800.14 PIK61246.1 - 0.014 15.5 1.7 0.031 14.4 0.1 2.4 2 0 0 2 2 2 0 Nuf2 family APG6_N PF17675.1 PIK61246.1 - 0.015 15.8 74.2 0.031 14.8 26.4 5.6 1 1 2 4 4 4 0 Apg6 coiled-coil region DUF4200 PF13863.6 PIK61246.1 - 1.3 9.4 57.8 0.12 12.8 16.3 4.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4200) RVT_1 PF00078.27 PIK61247.1 - 3.2e-22 79.1 0.0 2.1e-21 76.5 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 PIK61247.1 - 7.6e-07 29.4 0.6 9.4e-06 25.9 0.7 2.6 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK61247.1 - 0.00031 20.5 0.2 0.00058 19.7 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH_2 PF17919.1 PIK61247.1 - 0.0011 19.0 0.3 0.01 15.8 0.3 2.5 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 PIK61247.1 - 0.038 14.2 0.2 0.07 13.3 0.2 1.4 1 0 0 1 1 1 0 RNase H Phage_integrase PF00589.22 PIK61248.1 - 0.066 13.0 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 Phage integrase family PAS_3 PF08447.12 PIK61249.1 - 1.2e-16 60.7 0.2 6.3e-13 48.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 PIK61249.1 - 2e-10 40.7 0.1 5.4e-09 36.1 0.0 2.7 3 0 0 3 3 3 1 PAS fold PAS_11 PF14598.6 PIK61249.1 - 2.1e-10 40.7 0.0 1.8e-08 34.5 0.0 2.8 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 PIK61249.1 - 0.00014 22.0 0.0 0.00056 20.1 0.0 2.1 2 0 0 2 2 2 1 PAS domain nec1 PF10379.9 PIK61249.1 - 0.018 14.6 0.7 0.04 13.4 0.7 1.6 1 0 0 1 1 1 0 Virulence protein nec1 Aquarius_N PF16399.5 PIK61250.1 - 0.0051 14.9 0.0 0.0078 14.3 0.0 1.2 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus PYC_OADA PF02436.18 PIK61250.1 - 0.073 12.8 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 Conserved carboxylase domain IL2 PF00715.17 PIK61250.1 - 0.089 12.7 0.5 12 5.8 0.0 2.9 2 1 1 3 3 3 0 Interleukin 2 DED PF01335.21 PIK61252.1 - 4.2e-06 27.0 0.8 1.1e-05 25.7 0.8 1.8 1 0 0 1 1 1 1 Death effector domain SERTA PF06031.13 PIK61252.1 - 1.3 8.8 0.0 1.3 8.8 0.0 2.8 4 0 0 4 4 4 0 SERTA motif RHD3 PF05879.12 PIK61253.1 - 4.7e-06 25.1 0.0 4.7e-06 25.1 0.0 3.0 3 1 0 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 PIK61253.1 - 4.8e-06 26.7 0.0 4.8e-06 26.7 0.0 3.3 3 1 0 3 3 3 1 Dynamin family GBP PF02263.19 PIK61253.1 - 2.8e-05 23.5 0.1 9.9e-05 21.7 0.1 1.9 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 PIK61253.1 - 0.00049 20.2 0.0 0.0021 18.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 PIK61253.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4304 PF14137.6 PIK61253.1 - 1.5 9.0 5.7 0.8 9.9 0.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4304) CAF1C_H4-bd PF12265.8 PIK61255.1 - 5.7e-28 97.0 1.6 4.7e-27 94.1 0.7 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 PIK61255.1 - 1e-25 89.4 13.1 3.3e-07 30.9 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61255.1 - 1.7e-05 25.1 0.7 0.018 15.3 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Capsid_NCLDV PF04451.12 PIK61255.1 - 0.047 13.5 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein S-methyl_trans PF02574.16 PIK61256.1 - 1.5e-36 126.6 0.0 1.9e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DeoC PF01791.9 PIK61256.1 - 0.052 13.1 0.4 7.6 6.1 0.5 2.8 1 1 1 2 2 2 0 DeoC/LacD family aldolase Tubulin_C PF03953.17 PIK61257.1 - 1.5e-34 118.9 0.0 2e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 PIK61258.1 - 1.6e-56 191.6 0.1 2.7e-54 184.4 0.1 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin PF00091.25 PIK61259.1 - 4.7e-65 219.5 0.0 6.8e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 PIK61259.1 - 7.5e-50 168.3 0.0 1.2e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 PIK61259.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain RNA_pol_Rpb6 PF01192.22 PIK61260.1 - 1.5e-15 56.8 0.1 2.5e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 FMN_dh PF01070.18 PIK61261.1 - 9.2e-112 373.5 0.1 1.1e-111 373.3 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 PIK61261.1 - 1.2e-09 37.6 2.0 6.3e-09 35.3 1.8 2.1 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 PIK61261.1 - 1.1e-06 28.1 0.6 3.5e-06 26.4 0.1 1.8 1 1 1 2 2 2 1 Conserved region in glutamate synthase NMO PF03060.15 PIK61261.1 - 0.0006 19.3 3.8 0.0015 18.0 3.4 1.7 1 1 1 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 PIK61261.1 - 0.0058 16.1 0.1 0.051 13.0 0.0 2.2 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 PIK61261.1 - 0.021 14.1 1.1 2 7.7 0.1 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 PIK61261.1 - 0.034 13.5 0.2 0.096 12.0 0.1 1.8 2 0 0 2 2 2 0 Thiamine monophosphate synthase Prok-E2_E PF14462.6 PIK61264.1 - 0.00011 22.0 0.3 0.00031 20.5 0.5 1.6 2 0 0 2 2 2 1 Prokaryotic E2 family E EzrA PF06160.12 PIK61264.1 - 0.061 11.5 0.6 0.087 11.0 0.6 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA FATC PF02260.20 PIK61264.1 - 0.82 9.5 0.0 0.82 9.5 0.0 2.1 3 0 0 3 3 3 0 FATC domain RVT_1 PF00078.27 PIK61266.1 - 3.5e-34 118.3 0.2 4.4e-34 117.9 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-Nse PF11789.8 PIK61267.1 - 9.6e-17 60.6 2.1 1.8e-16 59.7 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 PIK61267.1 - 5.9e-06 26.2 0.1 1.5e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 RING-type zinc-finger U-box PF04564.15 PIK61267.1 - 3.6e-05 23.8 0.0 9.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-MIZ PF02891.20 PIK61267.1 - 0.00057 19.6 1.0 0.001 18.7 1.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 PIK61267.1 - 0.0033 17.2 0.1 0.0067 16.2 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF695 PF05117.12 PIK61267.1 - 0.05 13.8 0.1 0.21 11.8 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF695) zf-RING_2 PF13639.6 PIK61267.1 - 0.25 11.7 2.3 0.29 11.5 1.3 1.6 2 0 0 2 2 2 0 Ring finger domain Ras PF00071.22 PIK61268.1 - 2.4e-32 111.8 0.2 9e-23 80.6 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 PIK61268.1 - 4.1e-14 52.8 0.1 8.8e-08 32.4 0.1 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK61268.1 - 1.8e-08 34.0 0.0 2e-06 27.4 0.0 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family Plant_zn_clust PF10533.9 PIK61268.1 - 0.044 13.8 0.2 0.095 12.7 0.2 1.6 1 0 0 1 1 1 0 Plant zinc cluster domain MMR_HSR1_Xtn PF16897.5 PIK61268.1 - 0.087 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain CUB PF00431.20 PIK61270.1 - 0.018 15.3 0.0 0.14 12.5 0.0 2.3 2 1 0 2 2 2 0 CUB domain SSF PF00474.17 PIK61271.1 - 5e-12 45.4 4.1 6.3e-12 45.1 4.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family NdhL PF10716.9 PIK61271.1 - 0.38 10.7 4.6 0.31 11.0 2.7 1.8 1 1 1 2 2 2 0 NADH dehydrogenase transmembrane subunit HYR PF02494.16 PIK61272.1 - 8.3e-24 83.7 7.2 6.7e-15 55.2 1.9 2.1 2 0 0 2 2 2 2 HYR domain Adeno_E3A PF05248.12 PIK61272.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Adenovirus E3A Ammonium_transp PF00909.21 PIK61273.1 - 3.1e-94 315.9 16.7 3.9e-94 315.6 16.7 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Ank_2 PF12796.7 PIK61274.1 - 1.5e-43 147.2 1.8 5.1e-15 55.8 0.0 4.0 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK61274.1 - 1.4e-38 130.4 0.9 1e-09 38.5 0.2 5.6 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK61274.1 - 1.9e-36 123.9 0.4 1.7e-06 28.5 0.1 7.1 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK61274.1 - 1.1e-24 83.8 4.2 0.0016 18.8 0.1 8.8 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 PIK61274.1 - 1.5e-24 85.3 0.7 0.00068 20.0 0.0 8.0 8 0 0 8 8 8 5 Ankyrin repeat Death PF00531.22 PIK61274.1 - 1.1e-14 54.3 0.1 4.4e-14 52.4 0.1 2.0 2 0 0 2 2 2 1 Death domain COR PF16095.5 PIK61274.1 - 4.2e-09 36.5 0.0 8.8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 PIK61274.1 - 0.0003 21.0 0.1 0.14 12.4 0.0 2.6 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 PIK61274.1 - 0.1 13.1 0.0 0.23 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 PIK61274.1 - 0.11 12.3 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pkinase PF00069.25 PIK61275.1 - 3.5e-71 239.7 0.0 4.5e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61275.1 - 2.7e-33 115.4 0.0 3.8e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK61275.1 - 1.4e-09 37.6 0.1 1.4e-09 37.6 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK61275.1 - 0.00049 20.1 0.0 0.00076 19.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 PIK61275.1 - 0.0034 17.0 0.6 0.0061 16.2 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase CoaE PF01121.20 PIK61275.1 - 0.026 14.2 0.1 0.059 13.0 0.1 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase Serine_rich PF08824.10 PIK61276.1 - 0.15 12.0 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Serine rich protein interaction domain Hormone_recep PF00104.30 PIK61277.1 - 1.3e-28 100.0 0.4 2e-28 99.4 0.4 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 PIK61277.1 - 2.6e-08 34.2 5.2 5.2e-08 33.2 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) SK_channel PF03530.14 PIK61278.1 - 7.1e-43 145.2 4.2 7.1e-43 145.2 4.2 2.1 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.16 PIK61278.1 - 3.1e-33 113.8 8.1 7.6e-33 112.5 8.1 1.7 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.16 PIK61278.1 - 1.1e-14 54.1 1.9 1.1e-14 54.1 1.9 2.1 2 0 0 2 2 2 1 Ion channel Lig_chan PF00060.26 PIK61278.1 - 0.12 12.2 0.6 0.28 11.0 0.6 1.6 1 0 0 1 1 1 0 Ligand-gated ion channel Baculo_11_kDa PF06143.11 PIK61278.1 - 0.22 11.1 1.2 9.4 5.9 0.0 2.9 3 0 0 3 3 3 0 Baculovirus 11 kDa family RVT_1 PF00078.27 PIK61279.1 - 3.9e-27 95.2 0.1 4.6e-27 95.0 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) OSK PF17182.4 PIK61280.1 - 0.0043 16.3 0.2 0.0096 15.2 0.2 1.5 1 0 0 1 1 1 1 OSK domain PHD PF00628.29 PIK61280.1 - 0.24 11.3 3.7 0.77 9.7 2.5 2.6 2 0 0 2 2 2 0 PHD-finger Sec1 PF00995.23 PIK61281.1 - 1.9e-74 251.9 0.5 2.3e-74 251.7 0.5 1.0 1 0 0 1 1 1 1 Sec1 family DUF1638 PF07796.11 PIK61281.1 - 0.04 14.0 0.2 0.064 13.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) Glyoxalase PF00903.25 PIK61282.1 - 3.2e-05 24.1 0.0 5.5e-05 23.4 0.0 1.3 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 PIK61282.1 - 0.00057 20.1 0.0 0.00075 19.7 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 PIK61282.1 - 0.054 13.6 0.0 0.073 13.2 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain MAP65_ASE1 PF03999.12 PIK61283.1 - 0.12 11.1 11.8 0.007 15.1 4.0 2.4 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) TMA7 PF09072.10 PIK61283.1 - 0.15 12.9 1.9 0.43 11.5 1.9 1.7 1 0 0 1 1 1 0 Translation machinery associated TMA7 Ras_bdg_2 PF14847.6 PIK61284.1 - 0.0033 17.7 1.4 0.13 12.6 0.1 3.2 3 0 0 3 3 3 1 Ras-binding domain of Byr2 Methyltransf_23 PF13489.6 PIK61285.1 - 3.3e-10 40.1 0.0 4.3e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK61285.1 - 8.3e-06 26.5 0.0 1.9e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK61285.1 - 0.018 15.7 0.0 0.036 14.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 PIK61285.1 - 0.02 15.6 0.0 0.043 14.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 PIK61285.1 - 0.026 14.3 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ECSCR PF15820.5 PIK61286.1 - 0.096 12.5 0.5 0.15 11.9 0.5 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator eIF3_subunit PF08597.10 PIK61287.1 - 7.4e-51 173.4 34.5 8.4e-51 173.2 34.5 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit MRP-L28 PF09812.9 PIK61287.1 - 0.12 12.6 12.0 0.22 11.7 12.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Nop53 PF07767.11 PIK61287.1 - 0.46 9.8 28.3 0.093 12.1 23.1 1.9 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Myc-LZ PF02344.15 PIK61287.1 - 2 8.6 19.8 2.3 8.4 9.0 3.2 3 0 0 3 3 3 0 Myc leucine zipper domain Presenilin PF01080.17 PIK61287.1 - 4.8 5.8 8.0 4.9 5.8 8.0 1.2 1 0 0 1 1 1 0 Presenilin UPF0449 PF15136.6 PIK61288.1 - 1.3e-19 70.6 3.0 2.1e-19 69.8 3.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family UPF0449 Sec34 PF04136.15 PIK61288.1 - 0.0044 16.9 2.9 0.0069 16.3 2.9 1.2 1 0 0 1 1 1 1 Sec34-like family JIP_LZII PF16471.5 PIK61288.1 - 0.078 13.2 0.8 0.13 12.5 0.7 1.5 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II PRP1_N PF06424.12 PIK61288.1 - 0.11 12.9 0.4 0.19 12.1 0.2 1.6 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal ZapB PF06005.12 PIK61288.1 - 0.11 12.9 2.1 0.14 12.6 0.8 1.8 1 1 1 2 2 2 0 Cell division protein ZapB HflK_N PF12221.8 PIK61288.1 - 0.41 10.7 0.3 0.41 10.7 0.3 2.1 2 0 0 2 2 2 0 Bacterial membrane protein N terminal ubiquitin PF00240.23 PIK61289.1 - 6.5e-17 61.0 0.3 1.1e-16 60.4 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 PIK61289.1 - 6.8e-10 38.7 64.2 0.00021 21.2 8.9 6.5 4 2 1 5 5 5 3 STI1 domain UBA PF00627.31 PIK61289.1 - 1.2e-08 34.6 1.3 4.3e-08 32.9 1.3 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 PIK61289.1 - 0.00023 20.9 0.2 0.00041 20.1 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 PIK61289.1 - 0.00048 20.2 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 PIK61289.1 - 0.01 15.9 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair Ubiquitin_5 PF18037.1 PIK61289.1 - 0.012 15.9 0.1 0.028 14.8 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 PIK61289.1 - 0.023 15.2 0.0 0.064 13.8 0.0 1.8 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain MOR2-PAG1_C PF14225.6 PIK61289.1 - 0.11 12.3 1.2 0.25 11.2 1.2 1.6 1 0 0 1 1 1 0 Cell morphogenesis C-terminal UN_NPL4 PF11543.8 PIK61289.1 - 0.12 12.9 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Dynactin_p22 PF07426.11 PIK61289.1 - 0.25 11.2 2.7 0.36 10.7 0.4 2.2 2 0 0 2 2 2 0 Dynactin subunit p22 Rcd1 PF04078.13 PIK61289.1 - 0.36 10.1 4.6 0.1 11.9 0.4 2.0 2 0 0 2 2 2 0 Cell differentiation family, Rcd1-like DUF1400 PF07176.11 PIK61289.1 - 0.73 10.1 3.8 10 6.4 0.7 3.3 2 1 1 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF1400) LPD22 PF18834.1 PIK61289.1 - 1.4 9.1 5.4 14 6.0 0.3 3.3 2 2 1 3 3 3 0 Large polyvalent protein associated domain 22 CUE PF02845.16 PIK61289.1 - 2.5 7.9 5.3 0.66 9.7 0.1 2.7 2 0 0 2 2 2 0 CUE domain GlnE PF03710.15 PIK61289.1 - 3.1 7.1 11.7 2.7 7.3 1.1 3.1 2 1 1 3 3 3 0 Glutamate-ammonia ligase adenylyltransferase ComX PF05952.12 PIK61289.1 - 3.9 7.5 16.1 0.67 9.9 0.2 5.1 5 2 2 7 7 7 0 Bacillus competence pheromone ComX Fapy_DNA_glyco PF01149.24 PIK61290.1 - 2.7e-17 63.5 0.1 4.4e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 PIK61290.1 - 9.8e-05 22.3 0.0 0.00026 20.9 0.0 1.7 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FAO_M PF16350.5 PIK61290.1 - 0.0054 17.0 0.1 0.013 15.9 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Thioredoxin PF00085.20 PIK61291.1 - 3e-64 213.4 0.9 8.3e-32 109.3 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 PIK61291.1 - 1.2e-22 80.7 5.3 2.2e-08 34.2 2.8 4.2 2 1 2 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 PIK61291.1 - 1.6e-09 38.1 0.4 0.00039 20.8 0.0 3.6 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK61291.1 - 7.9e-09 35.7 0.2 0.049 14.0 0.0 4.3 4 2 2 6 6 6 2 Thioredoxin-like Thioredoxin_7 PF13899.6 PIK61291.1 - 1.1e-07 31.9 0.0 0.026 14.7 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 PIK61291.1 - 2.8e-06 26.9 1.8 0.084 12.2 0.0 3.4 3 1 1 4 4 4 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 PIK61291.1 - 7.7e-06 25.8 0.4 0.052 13.5 0.0 3.4 3 1 1 4 4 4 2 AhpC/TSA family Redoxin PF08534.10 PIK61291.1 - 0.00063 19.5 0.1 0.51 10.0 0.0 3.3 3 0 0 3 3 3 1 Redoxin Inos-1-P_synth PF01658.17 PIK61291.1 - 0.028 14.7 0.1 0.72 10.1 0.0 2.8 3 0 0 3 3 3 0 Myo-inositol-1-phosphate synthase Thioredoxin_4 PF13462.6 PIK61291.1 - 0.047 13.8 3.8 0.96 9.6 0.0 3.1 3 2 0 3 3 3 0 Thioredoxin HyaE PF07449.11 PIK61291.1 - 0.089 12.8 0.0 10 6.2 0.0 2.9 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE Ribosomal_L24e PF01246.20 PIK61292.1 - 2.9e-32 110.7 4.9 4.8e-32 110.0 4.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L24e DUF4495 PF14906.6 PIK61294.1 - 2.4e-78 263.4 8.9 4.6e-78 262.5 8.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4495) DUF5314 PF17241.2 PIK61294.1 - 0.0025 17.5 0.4 0.011 15.5 0.4 2.1 1 0 0 1 1 1 1 Family of unknown function (DUF5314) Cupin_8 PF13621.6 PIK61295.1 - 6.3e-36 124.4 0.2 1.1e-35 123.6 0.2 1.4 1 0 0 1 1 1 1 Cupin-like domain EF-hand_8 PF13833.6 PIK61295.1 - 2.3e-05 24.1 1.2 0.00067 19.4 0.3 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK61295.1 - 8.5e-05 21.9 0.4 0.00025 20.4 0.4 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK61295.1 - 0.00046 19.9 0.3 0.0018 18.1 0.3 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 PIK61295.1 - 0.00088 18.7 0.9 0.00088 18.7 0.9 2.2 2 1 1 3 3 3 1 EF hand JmjC PF02373.22 PIK61295.1 - 0.0024 18.3 0.0 0.0058 17.1 0.0 1.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase EF-hand_7 PF13499.6 PIK61295.1 - 0.008 16.6 1.4 0.015 15.7 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair Cupin_4 PF08007.12 PIK61295.1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Cupin superfamily protein PX PF00787.24 PIK61296.1 - 7.2e-15 55.0 0.4 9.6e-15 54.6 0.4 1.2 1 0 0 1 1 1 1 PX domain MutS_V PF00488.21 PIK61297.1 - 3.5e-70 235.9 0.0 6.5e-70 235.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 PIK61297.1 - 2e-29 103.2 2.7 2.5e-29 102.9 0.3 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 PIK61297.1 - 2.7e-13 50.4 0.2 7.6e-13 48.9 0.2 1.7 1 0 0 1 1 1 1 MutS domain II Fz PF01392.22 PIK61297.1 - 0.0035 18.0 0.1 0.013 16.1 0.1 2.0 1 0 0 1 1 1 1 Fz domain MutS_IV PF05190.18 PIK61297.1 - 0.0038 17.5 0.1 0.013 15.8 0.0 2.1 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.20 PIK61298.1 - 1.1e-29 102.9 0.0 2.1e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 MutS domain I Hormone_recep PF00104.30 PIK61299.1 - 2.3e-29 102.5 0.1 3e-29 102.1 0.1 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF2594 PF10769.9 PIK61299.1 - 0.072 13.1 0.1 0.14 12.2 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2594) RCC1 PF00415.18 PIK61300.1 - 0.00021 21.8 1.1 0.00085 19.9 1.1 1.9 1 1 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK61300.1 - 0.45 10.4 1.7 9.4 6.2 0.3 2.4 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 PIK61301.1 - 7e-17 61.8 13.8 2.6e-11 43.9 1.7 3.6 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 PIK61301.1 - 6.9e-10 38.5 11.6 8.9e-06 25.4 0.5 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Vps51 PF08700.11 PIK61302.1 - 1.7e-06 28.0 0.2 7.3e-06 26.0 0.2 2.2 1 1 0 1 1 1 1 Vps51/Vps67 BORCS8 PF10167.9 PIK61302.1 - 0.012 15.6 1.7 0.018 15.0 0.7 1.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 COG5 PF10392.9 PIK61302.1 - 0.07 13.3 2.9 0.076 13.2 0.4 2.2 3 0 0 3 3 3 0 Golgi transport complex subunit 5 WD40 PF00400.32 PIK61303.1 - 1.7e-15 57.1 0.3 4e-10 40.1 0.0 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 PIK61303.1 - 0.0018 17.3 0.0 0.048 12.6 0.0 2.0 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 PIK61303.1 - 0.0061 16.8 0.0 0.028 14.7 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 PIK61303.1 - 0.017 14.4 0.0 5 6.4 0.0 2.1 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal LBR_tudor PF09465.10 PIK61303.1 - 0.033 14.0 0.2 2.1 8.2 0.1 3.0 3 0 0 3 3 3 0 Lamin-B receptor of TUDOR domain PD40 PF07676.12 PIK61303.1 - 0.08 12.9 0.2 15 5.7 0.0 2.5 2 1 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 PIK61304.1 - 1.6e-11 44.5 0.2 4e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat Apt1 PF10351.9 PIK61305.1 - 5.2e-104 348.8 9.3 1e-103 347.8 9.3 1.5 1 0 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 PIK61305.1 - 1.6e-28 99.8 0.0 3.7e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 PIK61305.1 - 1.3e-07 31.7 0.1 9.5e-07 28.9 0.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_WPPW PF10359.9 PIK61305.1 - 0.0059 15.5 0.1 0.0059 15.5 0.1 2.3 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain VPS13_C PF16909.5 PIK61305.1 - 0.044 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal CN_hydrolase PF00795.22 PIK61306.1 - 1.1e-36 126.6 0.0 1.4e-20 73.7 0.0 2.1 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase GYF PF02213.16 PIK61308.1 - 1.7e-14 53.2 4.8 3.9e-14 52.1 4.8 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 PIK61308.1 - 0.025 14.4 0.0 0.077 12.8 0.0 1.8 1 0 0 1 1 1 0 GYF domain 2 PAPA-1 PF04795.12 PIK61308.1 - 8.7 7.2 12.7 14 6.6 2.6 3.2 3 0 0 3 3 3 0 PAPA-1-like conserved region Fzo_mitofusin PF04799.13 PIK61310.1 - 4.2e-61 205.2 2.8 4.2e-61 205.2 2.8 2.8 3 0 0 3 3 3 1 fzo-like conserved region Dynamin_N PF00350.23 PIK61310.1 - 2.7e-22 79.6 0.4 1.9e-21 76.8 0.0 2.5 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 PIK61310.1 - 0.00015 21.8 0.0 0.0011 19.0 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2025 PF09634.10 PIK61310.1 - 0.043 13.8 0.8 1.7 8.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2025) RasGEF_N_2 PF14663.6 PIK61310.1 - 0.18 12.2 2.3 2.7 8.4 0.2 3.2 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain CdvA PF18822.1 PIK61310.1 - 0.63 9.9 9.2 0.059 13.2 0.8 2.8 3 0 0 3 3 3 0 CdvA-like coiled-coil domain E2F_CC-MB PF16421.5 PIK61310.1 - 0.69 10.3 7.3 1.4 9.3 0.8 3.6 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain CorA PF01544.18 PIK61310.1 - 3.8 6.8 6.8 1.7 7.9 3.6 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Apolipoprotein PF01442.18 PIK61310.1 - 7.7 6.3 11.7 2.1 8.2 3.2 2.6 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain PP2C PF00481.21 PIK61311.1 - 2.7e-64 217.3 0.0 5.7e-64 216.2 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK61311.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C SWIM PF04434.17 PIK61312.1 - 1.7e-05 24.4 1.1 3.4e-05 23.4 1.1 1.6 1 0 0 1 1 1 1 SWIM zinc finger RAMA PF18755.1 PIK61313.1 - 7e-08 32.9 0.0 1.7e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated Borrelia_REV PF03978.13 PIK61313.1 - 0.042 13.8 1.0 0.095 12.7 1.0 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein YtxH PF12732.7 PIK61313.1 - 0.82 10.3 6.6 8.5 7.0 0.0 2.9 3 0 0 3 3 3 0 YtxH-like protein PH PF00169.29 PIK61314.1 - 2.9e-14 53.5 0.3 5.1e-14 52.7 0.3 1.4 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 PIK61314.1 - 0.0015 18.6 0.0 0.0036 17.4 0.0 1.7 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 PIK61314.1 - 0.051 13.9 0.0 0.15 12.4 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain TRAM_LAG1_CLN8 PF03798.16 PIK61316.1 - 8.5e-06 25.6 12.8 9.4e-06 25.5 12.8 1.0 1 0 0 1 1 1 1 TLC domain TRAM_LAG1_CLN8 PF03798.16 PIK61317.1 - 2.8e-14 53.3 13.8 3.3e-14 53.1 13.8 1.0 1 0 0 1 1 1 1 TLC domain Abhydro_lipase PF04083.16 PIK61317.1 - 0.048 13.3 1.1 0.1 12.2 0.5 1.9 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Pep3_Vps18 PF05131.14 PIK61318.1 - 3.9e-43 146.8 0.3 1.4e-42 145.0 0.0 2.2 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 PIK61318.1 - 1.7e-11 44.2 13.2 2.5e-10 40.4 4.0 3.5 3 1 0 3 3 3 2 Region in Clathrin and VPS DUF1664 PF07889.12 PIK61318.1 - 0.00081 19.4 1.7 0.0034 17.4 1.7 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) zf-RING_11 PF17123.5 PIK61318.1 - 0.0031 17.2 0.5 0.0094 15.7 0.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger PI3K_P85_iSH2 PF16454.5 PIK61318.1 - 0.0044 16.6 0.3 0.015 14.9 0.3 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Ephrin_lbd PF01404.19 PIK61318.1 - 0.007 16.4 0.2 0.019 15.0 0.2 1.7 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain zf-C3HC4_2 PF13923.6 PIK61318.1 - 0.01 15.7 0.1 0.01 15.7 0.1 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK61318.1 - 0.038 14.0 0.1 0.13 12.3 0.1 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 PIK61318.1 - 0.042 13.8 0.1 0.16 11.9 0.1 2.0 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 PIK61318.1 - 0.063 13.6 1.6 0.14 12.5 0.1 2.4 2 0 0 2 2 1 0 Ring finger domain XhlA PF10779.9 PIK61318.1 - 0.11 12.7 0.3 0.42 10.8 0.3 2.1 1 0 0 1 1 1 0 Haemolysin XhlA EF-hand_1 PF00036.32 PIK61320.1 - 3.3e-05 23.1 0.0 7e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 PIK61320.1 - 0.00017 22.0 0.1 0.00054 20.4 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 PIK61320.1 - 0.00024 20.5 0.0 0.00046 19.5 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK61320.1 - 0.00046 19.9 0.0 0.001 18.8 0.0 1.7 1 1 0 1 1 1 1 EF-hand domain Ribosomal_L4 PF00573.22 PIK61320.1 - 0.086 12.5 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family Zincin_1 PF06262.11 PIK61320.1 - 0.13 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Zincin-like metallopeptidase zf-RanBP PF00641.18 PIK61321.1 - 7.8e-08 31.5 7.1 1.9e-07 30.2 7.1 1.7 1 1 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 PIK61321.1 - 1.4e-05 24.8 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ly49 PF08391.10 PIK61323.1 - 0.029 14.7 0.5 0.12 12.8 0.5 2.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Phage_Gp23 PF10669.9 PIK61323.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF4834 PF16118.5 PIK61323.1 - 2.1 9.3 0.0 2.1 9.3 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2207 PF09972.9 PIK61324.1 - 4.7e-06 25.6 0.0 6.1e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Endomucin PF07010.12 PIK61324.1 - 0.013 15.5 8.9 0.02 14.9 8.9 1.3 1 0 0 1 1 1 0 Endomucin Orf78 PF06024.12 PIK61324.1 - 0.014 15.7 0.9 0.036 14.4 0.5 1.8 1 1 1 2 2 2 0 Orf78 (ac78) DUF3139 PF11337.8 PIK61324.1 - 0.024 15.3 0.9 0.066 13.9 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Ig_3 PF13927.6 PIK61324.1 - 0.045 14.3 0.3 0.045 14.3 0.3 2.4 2 1 1 3 3 3 0 Immunoglobulin domain LAX PF15681.5 PIK61324.1 - 0.059 12.2 0.9 0.095 11.5 0.1 1.7 2 0 0 2 2 2 0 Lymphocyte activation family X Baculo_11_kDa PF06143.11 PIK61324.1 - 0.094 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family V-set PF07686.17 PIK61324.1 - 0.1 12.8 2.6 0.19 11.9 0.4 2.6 2 1 0 2 2 2 0 Immunoglobulin V-set domain SIT PF15330.6 PIK61324.1 - 0.14 12.6 0.2 0.61 10.5 0.0 2.2 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.6 PIK61324.1 - 0.23 11.4 5.7 1.4 8.8 5.7 2.1 1 1 0 1 1 1 0 TMEM154 protein family Sigma_reg_N PF13800.6 PIK61324.1 - 0.47 10.8 3.4 0.26 11.6 0.4 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal V-set PF07686.17 PIK61325.1 - 0.00033 20.8 2.8 0.0012 18.9 0.8 2.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61325.1 - 0.0059 17.2 0.8 0.027 15.1 0.2 2.3 2 1 0 2 2 2 1 Immunoglobulin domain Sialidase PF02973.16 PIK61325.1 - 0.035 13.6 0.3 0.049 13.1 0.3 1.3 1 0 0 1 1 1 0 Sialidase, N-terminal domain ig PF00047.25 PIK61325.1 - 0.05 13.8 0.4 0.39 10.9 0.4 2.2 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK61326.1 - 0.0031 17.7 2.4 0.013 15.7 0.5 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61326.1 - 0.047 14.3 2.2 0.25 12.0 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 PIK61326.1 - 0.15 12.3 3.1 1.8 8.8 0.1 2.8 3 0 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 PIK61326.1 - 0.52 10.7 5.7 0.23 11.8 1.7 2.3 1 1 1 2 2 2 0 Immunoglobulin domain THAP PF05485.12 PIK61327.1 - 1.7e-10 41.7 1.1 3e-10 40.9 1.1 1.4 1 0 0 1 1 1 1 THAP domain V-set PF07686.17 PIK61328.1 - 0.0093 16.1 4.0 0.015 15.5 1.8 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61328.1 - 0.019 15.5 1.9 0.058 14.0 0.6 2.3 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK61328.1 - 0.071 13.2 1.3 0.11 12.6 0.2 2.0 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61328.1 - 0.95 9.8 6.4 0.86 10.0 3.6 2.3 1 1 0 2 2 2 0 Immunoglobulin domain TMEM154 PF15102.6 PIK61329.1 - 0.0012 18.7 10.9 0.0071 16.3 11.0 2.1 1 1 0 1 1 1 1 TMEM154 protein family Baculo_11_kDa PF06143.11 PIK61329.1 - 0.0037 16.8 1.1 0.0083 15.7 0.4 1.9 2 0 0 2 2 2 1 Baculovirus 11 kDa family SUR7 PF06687.12 PIK61329.1 - 0.0085 15.7 2.5 0.023 14.3 2.5 1.7 1 1 0 1 1 1 1 SUR7/PalI family V-set PF07686.17 PIK61329.1 - 0.011 15.9 1.5 0.031 14.4 0.4 2.4 2 1 0 2 2 2 0 Immunoglobulin V-set domain Ly49 PF08391.10 PIK61329.1 - 0.012 16.0 0.3 0.033 14.5 0.3 1.7 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region I-set PF07679.16 PIK61329.1 - 0.073 13.1 0.2 0.37 10.9 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain HemY_N PF07219.13 PIK61329.1 - 0.088 13.0 0.5 0.19 12.0 0.5 1.4 1 0 0 1 1 1 0 HemY protein N-terminus Ig_3 PF13927.6 PIK61329.1 - 0.1 13.2 0.2 0.1 13.2 0.2 3.1 2 1 0 2 2 2 0 Immunoglobulin domain Orf78 PF06024.12 PIK61329.1 - 0.13 12.5 0.6 0.29 11.5 0.1 1.8 2 0 0 2 2 2 0 Orf78 (ac78) DUF3377 PF11857.8 PIK61329.1 - 0.3 11.1 1.6 0.37 10.7 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF4834 PF16118.5 PIK61329.1 - 1 10.3 0.0 1 10.3 0.0 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) DUF5383 PF17355.2 PIK61329.1 - 1.3 9.4 4.0 0.64 10.4 0.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5383) RIFIN PF02009.16 PIK61329.1 - 1.6 8.5 11.8 0.66 9.8 8.5 1.8 1 1 1 2 2 2 0 Rifin Stevor PF17410.2 PIK61329.1 - 2.6 7.5 11.3 0.34 10.4 3.4 2.1 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame Exo_endo_phos_2 PF14529.6 PIK61330.1 - 6.7e-09 35.6 0.4 1.5e-08 34.5 0.4 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK61330.1 - 3.4e-07 30.0 0.1 6.9e-07 29.0 0.1 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family V-set PF07686.17 PIK61331.1 - 0.00083 19.5 0.6 0.0042 17.2 0.6 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61331.1 - 0.0031 18.1 0.2 0.01 16.4 0.2 1.8 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 PIK61331.1 - 0.044 13.9 0.5 0.7 10.1 0.5 2.4 1 1 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 PIK61331.1 - 1.6 9.1 5.6 0.95 9.8 2.2 2.3 2 1 0 2 2 2 0 Immunoglobulin domain Baculo_11_kDa PF06143.11 PIK61333.1 - 0.0013 18.3 0.7 0.0041 16.6 0.7 1.8 1 0 0 1 1 1 1 Baculovirus 11 kDa family Orf78 PF06024.12 PIK61333.1 - 0.027 14.8 0.1 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) V-set PF07686.17 PIK61333.1 - 0.032 14.4 0.4 0.032 14.4 0.4 3.0 3 1 0 3 3 3 0 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61333.1 - 0.046 14.3 1.9 0.11 13.2 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain DUF4834 PF16118.5 PIK61333.1 - 0.054 14.5 0.3 0.37 11.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ly49 PF08391.10 PIK61333.1 - 0.075 13.4 0.2 0.21 12.0 0.2 1.7 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DisA_N PF02457.16 PIK61333.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding Ion_trans PF00520.31 PIK61333.1 - 0.14 11.4 2.2 0.51 9.5 0.1 1.8 1 1 1 2 2 2 0 Ion transport protein Stevor PF17410.2 PIK61333.1 - 0.3 10.6 6.4 0.85 9.1 6.4 1.7 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 PIK61333.1 - 0.55 10.1 9.9 2.9 7.8 9.9 2.1 1 1 0 1 1 1 0 TMEM154 protein family DUF4713 PF15831.5 PIK61333.1 - 2.3 8.8 9.3 5.4 7.5 9.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Integrase_H2C2 PF17921.1 PIK61334.1 - 1.9e-19 69.5 0.1 2.8e-19 69.0 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK61334.1 - 3e-05 24.2 0.0 5.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger NEAT PF05031.12 PIK61334.1 - 0.057 14.0 0.0 0.088 13.4 0.0 1.3 1 0 0 1 1 1 0 Iron Transport-associated domain RT_RNaseH_2 PF17919.1 PIK61335.1 - 3.9e-37 126.3 0.0 7.4e-37 125.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK61335.1 - 1e-35 122.2 0.0 1.6e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK61335.1 - 1.3e-07 31.4 0.0 2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MATalpha_HMGbox PF04769.12 PIK61335.1 - 0.017 14.5 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Baculo_11_kDa PF06143.11 PIK61336.1 - 0.006 16.1 1.8 0.016 14.8 1.8 1.6 1 0 0 1 1 1 1 Baculovirus 11 kDa family DUF2207 PF09972.9 PIK61336.1 - 0.039 12.7 1.2 0.079 11.7 1.2 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 PIK61336.1 - 0.066 14.2 1.4 0.37 11.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 PIK61336.1 - 0.1 12.9 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Orf78 (ac78) MRAP PF15183.6 PIK61336.1 - 0.16 11.9 0.2 0.39 10.7 0.2 1.6 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family TMEM154 PF15102.6 PIK61336.1 - 4.3 7.2 12.4 0.11 12.4 3.6 2.2 1 1 1 2 2 2 0 TMEM154 protein family DUF4713 PF15831.5 PIK61336.1 - 5.5 7.5 9.3 13 6.3 9.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) V-set PF07686.17 PIK61337.1 - 0.00059 20.0 1.6 0.0028 17.8 0.9 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61337.1 - 0.0019 18.8 1.3 0.0097 16.5 0.2 2.4 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK61337.1 - 0.0027 17.8 1.3 0.027 14.7 0.8 2.6 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK61337.1 - 0.027 14.5 0.3 0.063 13.3 0.1 1.9 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61337.1 - 1.8 9.0 5.4 3 8.3 2.0 2.7 2 2 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK61338.1 - 2.1e-05 24.6 1.7 8.4e-05 22.7 0.2 2.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61338.1 - 0.0022 18.6 0.4 0.0067 17.0 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK61338.1 - 0.022 14.8 0.1 0.075 13.1 0.0 2.0 1 1 1 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61338.1 - 0.38 11.1 3.8 0.34 11.3 0.7 2.6 1 1 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 PIK61339.1 - 0.00013 22.1 2.4 0.0019 18.4 0.5 2.8 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK61339.1 - 0.004 17.7 1.8 0.017 15.7 0.2 2.5 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 PIK61339.1 - 0.033 14.4 0.6 0.43 10.8 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 PIK61339.1 - 0.065 13.6 4.8 0.13 12.6 1.4 2.8 1 1 1 2 2 2 0 Immunoglobulin domain I-set PF07679.16 PIK61339.1 - 0.11 12.5 0.3 0.33 11.1 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin I-set domain DUF5641 PF18701.1 PIK61339.1 - 0.2 11.9 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5641) DUF2207 PF09972.9 PIK61340.1 - 0.00044 19.2 0.0 0.00081 18.3 0.0 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 PIK61340.1 - 0.09 13.1 0.0 0.29 11.4 0.0 1.9 1 0 0 1 1 1 0 Orf78 (ac78) Ig_3 PF13927.6 PIK61341.1 - 0.0075 16.8 0.5 0.022 15.3 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 PIK61341.1 - 0.059 13.6 1.2 0.24 11.6 0.3 2.3 2 1 0 2 2 2 0 Immunoglobulin V-set domain ig PF00047.25 PIK61341.1 - 0.077 13.2 0.1 1.5 9.0 0.1 2.6 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 PIK61342.1 - 0.026 14.7 0.9 0.09 13.0 0.4 2.1 2 1 0 2 2 2 0 Immunoglobulin V-set domain V-set PF07686.17 PIK61343.1 - 4.6e-08 33.2 6.8 0.014 15.5 0.6 4.4 2 2 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 PIK61343.1 - 9.7e-07 28.9 3.6 0.072 13.3 0.1 4.3 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 PIK61343.1 - 8.2e-05 22.6 0.1 0.55 10.3 0.0 3.3 4 0 0 4 4 4 2 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK61343.1 - 0.0012 19.3 4.9 1.3 9.7 0.4 4.3 2 2 0 2 2 2 2 Immunoglobulin domain HipA_C PF07804.12 PIK61343.1 - 0.018 14.7 0.1 3.8 7.1 0.0 2.2 2 0 0 2 2 2 0 HipA-like C-terminal domain DUF3877 PF12993.7 PIK61343.1 - 0.062 13.2 0.6 11 5.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3877) DUF4968 PF16338.5 PIK61343.1 - 0.11 12.8 2.1 14 6.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4968) FlpD PF02662.16 PIK61343.1 - 0.15 12.0 1.9 15 5.6 0.1 2.3 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit Marek_A PF02124.15 PIK61344.1 - 0.0013 18.6 0.3 0.0021 17.9 0.3 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.12 PIK61344.1 - 0.017 15.2 1.0 0.043 13.9 1.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK61344.1 - 0.052 13.9 1.8 0.068 13.6 0.3 2.0 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 PIK61344.1 - 0.059 13.4 0.1 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_3 PF13927.6 PIK61344.1 - 1.5 9.5 5.7 31 5.2 0.1 3.4 3 1 1 4 4 4 0 Immunoglobulin domain TMEM154 PF15102.6 PIK61344.1 - 1.9 8.4 5.5 1.1 9.2 0.4 2.5 2 1 0 2 2 2 0 TMEM154 protein family Ig_3 PF13927.6 PIK61345.1 - 2.8e-07 31.0 2.1 7.1e-06 26.5 0.2 2.7 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK61345.1 - 0.00012 22.0 0.5 0.00037 20.5 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK61345.1 - 0.002 18.2 2.2 0.0046 17.0 0.8 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK61345.1 - 0.011 16.0 4.1 0.13 12.6 0.1 2.9 2 1 1 3 3 3 0 Immunoglobulin domain Marek_A PF02124.15 PIK61345.1 - 0.014 15.2 2.2 0.017 15.0 0.3 1.9 2 0 0 2 2 2 0 Marek's disease glycoprotein A LRR19-TM PF15176.6 PIK61345.1 - 0.02 14.9 0.5 0.07 13.1 0.5 1.9 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain C1-set PF07654.15 PIK61345.1 - 0.021 15.2 0.5 0.021 15.2 0.5 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain V-set PF07686.17 PIK61345.1 - 0.11 12.7 1.8 0.16 12.2 0.2 2.2 2 1 0 2 2 2 0 Immunoglobulin V-set domain ig PF00047.25 PIK61345.1 - 0.19 11.9 5.0 0.9 9.8 0.4 2.5 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 PIK61346.1 - 3.3e-07 30.8 1.7 1.6e-05 25.4 0.4 3.1 2 1 1 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 PIK61346.1 - 1.2e-05 25.6 3.7 0.0033 17.7 1.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 PIK61346.1 - 8.3e-05 22.9 1.6 0.0013 19.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 PIK61346.1 - 0.0004 20.4 2.4 0.0013 18.7 0.2 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ThiF PF00899.21 PIK61346.1 - 0.071 12.4 0.5 0.11 11.8 0.5 1.5 1 1 0 1 1 1 0 ThiF family I-set PF07679.16 PIK61346.1 - 0.09 12.9 0.6 0.54 10.4 0.1 2.4 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61347.1 - 0.00044 20.5 0.3 0.89 9.9 0.0 2.3 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK61347.1 - 0.0037 17.8 0.2 0.92 10.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Gemini_C4 PF01492.17 PIK61347.1 - 0.028 14.3 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Geminivirus C4 protein THAP PF05485.12 PIK61348.1 - 2.6e-13 50.7 2.2 5.4e-13 49.7 2.2 1.6 1 0 0 1 1 1 1 THAP domain Ig_3 PF13927.6 PIK61351.1 - 4.7e-12 46.3 7.1 2.6e-05 24.7 0.3 3.7 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK61351.1 - 2.1e-10 40.6 4.7 0.00025 21.1 0.4 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 PIK61351.1 - 1.2e-07 32.0 7.7 0.0026 18.1 0.2 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 PIK61351.1 - 1.7e-07 31.2 4.7 0.0004 20.4 0.1 3.2 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 PIK61351.1 - 0.00019 21.6 6.3 0.0012 19.0 0.6 2.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain V-set_CD47 PF08204.11 PIK61351.1 - 0.038 14.0 4.2 0.15 12.1 0.4 2.6 1 1 0 2 2 2 0 CD47 immunoglobulin-like domain Pkinase_Tyr PF07714.17 PIK61352.1 - 1.7e-13 50.5 0.2 2.7e-10 40.0 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase C2-set_2 PF08205.12 PIK61352.1 - 4.9e-05 23.3 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Pkinase PF00069.25 PIK61352.1 - 0.00015 21.2 0.3 0.002 17.6 0.0 2.5 2 1 1 3 3 3 1 Protein kinase domain DUF2270 PF10028.9 PIK61352.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) DUF3433 PF11915.8 PIK61352.1 - 0.078 13.4 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3433) Ig_3 PF13927.6 PIK61353.1 - 6.1e-18 65.2 8.4 1.8e-07 31.6 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK61353.1 - 9.3e-13 48.2 1.8 1.2e-05 25.4 0.0 4.1 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 PIK61353.1 - 1.1e-10 41.4 3.3 0.00016 21.7 0.0 4.5 3 1 2 5 5 5 3 Immunoglobulin I-set domain C2-set_2 PF08205.12 PIK61353.1 - 9.3e-09 35.2 6.2 0.011 15.8 1.5 4.3 4 1 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 PIK61353.1 - 4e-08 33.5 8.4 0.1 13.0 0.3 4.8 4 1 1 5 5 5 2 Immunoglobulin domain V-set PF07686.17 PIK61353.1 - 0.00054 20.1 0.8 5.6 7.2 0.0 4.3 4 1 0 4 4 4 1 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 PIK61353.1 - 0.082 12.9 9.0 3.1 7.8 0.3 4.0 4 1 0 4 4 4 0 Ig-like C2-type domain Pkinase_Tyr PF07714.17 PIK61354.1 - 4.1e-25 88.5 0.0 2.2e-24 86.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 PIK61354.1 - 1.1e-13 51.6 7.7 0.071 13.7 0.0 7.6 7 1 0 7 7 7 4 Immunoglobulin domain Pkinase PF00069.25 PIK61354.1 - 1.1e-13 51.2 0.0 2.3e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain C2-set_2 PF08205.12 PIK61354.1 - 4.2e-13 49.2 5.1 0.0001 22.3 0.0 4.2 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 PIK61354.1 - 4.9e-07 29.9 1.4 1 9.6 0.1 3.8 3 0 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK61354.1 - 1.6e-06 27.6 0.0 0.078 12.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK61354.1 - 3.1e-05 24.0 3.4 0.038 14.0 0.0 5.4 7 0 0 7 7 6 1 Immunoglobulin I-set domain ig PF00047.25 PIK61354.1 - 0.003 17.7 12.6 2.2 8.5 0.0 5.8 6 0 0 6 6 6 2 Immunoglobulin domain C1-set PF07654.15 PIK61354.1 - 0.0044 17.4 6.7 1.3 9.5 0.9 3.9 4 0 0 4 4 3 2 Immunoglobulin C1-set domain Ig_2 PF13895.6 PIK61354.1 - 0.0057 17.0 10.7 2.9 8.3 0.0 6.4 7 0 0 7 7 7 1 Immunoglobulin domain CDC45 PF02724.14 PIK61354.1 - 0.13 10.6 0.0 0.23 9.7 0.0 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF3377 PF11857.8 PIK61354.1 - 0.13 12.2 0.3 0.42 10.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) RVT_1 PF00078.27 PIK61355.1 - 3.8e-30 105.1 0.1 5.2e-30 104.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK61356.1 - 8.3e-21 74.4 0.0 1.3e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK61356.1 - 1.9e-16 59.9 2.6 3.9e-16 58.9 2.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK61356.1 - 7.9e-16 57.9 0.0 2.2e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK61356.1 - 1.4e-12 47.8 0.0 4.4e-12 46.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 PIK61356.1 - 0.00039 20.1 0.0 0.0012 18.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK61356.1 - 0.0042 17.3 1.2 0.009 16.2 1.2 1.6 1 0 0 1 1 1 1 H2C2 zinc finger ig PF00047.25 PIK61357.1 - 4.9e-05 23.4 0.3 0.0056 16.8 0.0 2.9 3 1 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 PIK61357.1 - 8.5e-05 22.7 0.2 0.042 14.0 0.1 3.1 3 1 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK61357.1 - 0.00068 19.7 0.1 0.0086 16.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61357.1 - 0.00075 19.8 1.2 0.14 12.5 0.1 3.4 3 2 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK61357.1 - 0.0074 16.9 0.1 1.9 9.1 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Ig_6 PF18452.1 PIK61357.1 - 0.035 13.7 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin domain Izumo-Ig PF16706.5 PIK61357.1 - 0.051 13.7 0.1 0.3 11.2 0.0 2.2 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK61357.1 - 0.1 12.9 0.1 0.69 10.2 0.0 2.2 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Filamin PF00630.19 PIK61357.1 - 0.17 12.7 0.8 9.3 7.1 0.5 2.9 2 1 0 2 2 2 0 Filamin/ABP280 repeat Pkinase_Tyr PF07714.17 PIK61358.1 - 5.2e-85 284.8 0.0 6.9e-85 284.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61358.1 - 1.2e-38 133.0 0.0 1.9e-38 132.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 PIK61358.1 - 1.9e-30 104.7 0.0 2.7e-13 49.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK61358.1 - 3.3e-25 88.5 5.6 8.3e-11 42.3 0.3 4.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK61358.1 - 8.8e-20 70.8 2.2 9.3e-07 29.1 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK61358.1 - 8.2e-16 58.0 1.4 3.5e-07 30.3 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 PIK61358.1 - 0.0026 17.8 0.8 3.3 7.9 0.0 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Peptidase_S9_N PF02897.15 PIK61358.1 - 0.13 11.0 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain V-set_CD47 PF08204.11 PIK61358.1 - 0.14 12.2 0.1 5.9 6.9 0.0 2.7 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain DUF5412 PF17428.2 PIK61358.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5412) ATP-synt_F6 PF05511.11 PIK61359.1 - 1.3e-27 96.1 0.1 1.5e-27 95.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 DUF3562 PF12085.8 PIK61359.1 - 0.0082 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3562) fn3 PF00041.21 PIK61361.1 - 4.9e-06 26.8 0.0 8.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CYYR1 PF10873.8 PIK61361.1 - 0.086 13.3 0.5 0.17 12.3 0.0 1.8 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 I-set PF07679.16 PIK61362.1 - 1.3e-29 102.1 0.0 4.9e-12 45.8 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK61362.1 - 1.8e-26 92.6 0.0 8.2e-12 45.6 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK61362.1 - 1.4e-17 63.8 0.0 2.4e-07 31.0 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK61362.1 - 5.5e-15 55.3 0.0 3.2e-07 30.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 PIK61362.1 - 1.2e-12 48.0 0.0 0.001 19.2 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 PIK61362.1 - 1.1e-07 31.2 0.0 0.005 16.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 PIK61362.1 - 3.3e-06 27.1 0.1 0.043 13.9 0.0 2.5 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 PIK61362.1 - 1.6e-05 25.2 0.0 0.00074 19.9 0.0 2.9 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 PIK61362.1 - 0.00031 20.7 0.0 0.89 9.7 0.0 2.7 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 PIK61362.1 - 0.0015 18.8 0.0 0.071 13.4 0.0 2.7 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain DUF2387 PF09526.10 PIK61362.1 - 0.038 14.1 0.1 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) C2-set PF05790.15 PIK61362.1 - 0.19 11.9 0.0 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin C2-set domain A_deaminase PF00962.22 PIK61363.1 - 7.4e-123 410.0 0.1 1.7e-122 408.9 0.1 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase Integrin_beta PF00362.18 PIK61364.1 - 4.9e-95 317.9 0.0 7.5e-95 317.3 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.3 PIK61364.1 - 2.5e-10 39.9 10.9 2.5e-10 39.9 10.9 4.9 4 1 1 5 5 5 1 Integrin plexin domain I-EGF_1 PF18372.1 PIK61364.1 - 5.8e-08 32.7 8.0 5.8e-08 32.7 8.0 7.1 6 0 0 6 6 6 3 Integrin beta epidermal growth factor like domain 1 Integrin_b_cyt PF08725.11 PIK61364.1 - 9.1e-08 31.7 2.2 1.9e-07 30.6 2.2 1.6 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain EGF_2 PF07974.13 PIK61364.1 - 4.1e-06 27.0 90.7 0.0051 17.2 14.7 5.9 4 1 0 4 4 4 4 EGF-like domain Pkinase PF00069.25 PIK61365.1 - 3.4e-75 252.8 0.0 4.3e-75 252.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61365.1 - 3.6e-31 108.4 0.0 4.2e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK61365.1 - 0.00015 21.2 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 PIK61365.1 - 0.00044 19.7 0.5 0.001 18.5 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK61365.1 - 0.018 15.0 0.1 5.8 6.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 PIK61365.1 - 0.019 14.5 0.0 0.043 13.3 0.0 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 PIK61365.1 - 0.029 13.2 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase TetR_C_27 PF17935.1 PIK61365.1 - 0.11 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF4312 PF14189.6 PIK61365.1 - 0.11 12.5 0.5 0.24 11.4 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) Peptidase_S8 PF00082.22 PIK61366.1 - 1.6e-51 175.3 3.8 2.5e-51 174.7 3.8 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 PIK61366.1 - 1.2e-26 92.5 0.2 2.3e-26 91.6 0.2 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 PIK61366.1 - 1.8e-21 76.7 3.4 3.5e-21 75.7 3.4 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain GF_recep_IV PF14843.6 PIK61366.1 - 0.008 16.0 7.5 0.023 14.5 7.5 1.7 1 0 0 1 1 1 1 Growth factor receptor domain IV Baculo_p48 PF04878.13 PIK61366.1 - 0.038 12.9 1.3 0.057 12.4 1.3 1.2 1 0 0 1 1 1 0 Baculovirus P48 protein DUF5305 PF17231.2 PIK61366.1 - 0.14 11.6 0.1 0.26 10.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Ost5 PF05251.12 PIK61366.1 - 6.4 7.1 6.7 12 6.3 0.5 3.1 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 Sugar_tr PF00083.24 PIK61368.1 - 4.9e-32 111.4 5.8 7.3e-32 110.8 5.8 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK61368.1 - 2.1e-26 92.7 17.2 3.6e-26 91.9 17.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 PIK61368.1 - 0.00014 20.6 2.4 0.00014 20.6 2.4 2.4 3 0 0 3 3 3 1 MFS/sugar transport protein TRI12 PF06609.13 PIK61368.1 - 0.0024 16.4 2.0 0.0046 15.4 2.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) BT1 PF03092.16 PIK61368.1 - 0.048 11.9 5.6 0.077 11.2 0.6 2.6 3 0 0 3 3 3 0 BT1 family Forkhead PF00250.18 PIK61369.1 - 6.2e-24 84.1 0.0 1.8e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Forkhead domain DUF3408 PF11888.8 PIK61369.1 - 0.046 13.9 1.7 0.094 12.8 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CTD_bind PF04818.13 PIK61371.1 - 2.1e-17 63.7 0.0 7.3e-17 61.9 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.5 PIK61371.1 - 4e-08 33.6 1.3 6.9e-08 32.8 0.3 1.9 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour FadA PF09403.10 PIK61371.1 - 0.17 12.4 1.6 0.69 10.4 0.9 2.2 2 0 0 2 2 2 0 Adhesion protein FadA CTK3 PF12243.8 PIK61371.1 - 0.17 11.9 0.6 0.37 10.8 0.1 1.9 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 Peptidase_S8 PF00082.22 PIK61372.1 - 4.9e-46 157.3 1.2 6.7e-46 156.9 1.2 1.2 1 0 0 1 1 1 1 Subtilase family GF_recep_IV PF14843.6 PIK61372.1 - 3.3e-33 114.3 357.9 1.9e-06 27.7 27.3 13.7 1 1 15 16 16 16 14 Growth factor receptor domain IV P_proprotein PF01483.20 PIK61372.1 - 2.8e-26 91.3 0.1 4.8e-26 90.6 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 PIK61372.1 - 6.3e-22 78.1 0.2 1.2e-21 77.3 0.2 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain VSP PF03302.13 PIK61372.1 - 1.6e-13 50.3 318.2 3e-06 26.3 35.1 15.5 1 1 11 12 12 12 8 Giardia variant-specific surface protein Furin-like_2 PF15913.5 PIK61372.1 - 2.8e-11 43.5 309.3 6.2e-08 32.8 20.8 16.1 1 1 13 15 15 15 10 Furin-like repeat, cysteine-rich Furin-like PF00757.20 PIK61372.1 - 0.00016 21.6 33.2 0.00016 21.6 33.2 14.7 1 1 12 15 15 15 5 Furin-like cysteine rich region Iso_dh PF00180.20 PIK61373.1 - 4.6e-76 256.2 0.0 6.2e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 PIK61374.1 - 3.5e-11 42.8 0.0 3.9e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase NTPase_I-T PF01931.18 PIK61375.1 - 4e-11 43.0 0.0 6e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF84 DUF2781 PF10914.8 PIK61376.1 - 6.2e-15 55.9 8.5 8.7e-15 55.4 8.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF1772 PF08592.11 PIK61377.1 - 3.2 8.1 6.0 1.5 9.2 3.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) SCAPER_N PF16501.5 PIK61378.1 - 9.5e-48 160.2 4.5 1.7e-42 143.4 1.4 2.4 2 0 0 2 2 2 2 S phase cyclin A-associated protein in the endoplasmic reticulum UvrA_inter PF17760.1 PIK61378.1 - 0.041 14.0 0.1 0.066 13.3 0.1 1.3 1 0 0 1 1 1 0 UvrA interaction domain MAP70 PF07058.11 PIK61378.1 - 0.13 11.0 7.5 0.16 10.7 7.5 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Secretin_N_2 PF07655.13 PIK61378.1 - 0.89 10.1 16.7 0.18 12.3 0.7 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain HYLS1_C PF15311.6 PIK61378.1 - 1.1 10.0 5.0 0.27 12.0 0.3 2.4 2 1 0 2 2 2 0 Hydrolethalus syndrome protein 1 C-terminus PknG_TPR PF16918.5 PIK61379.1 - 0.097 11.4 0.1 0.12 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat RRP7 PF12923.7 PIK61379.1 - 0.1 12.7 7.5 0.23 11.6 7.5 1.6 1 1 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain CaM_binding PF07839.11 PIK61379.1 - 0.12 13.1 8.7 0.23 12.2 8.7 1.4 1 0 0 1 1 1 0 Plant calmodulin-binding domain zf-met PF12874.7 PIK61380.1 - 2.6e-07 30.8 0.1 8.4e-07 29.2 0.1 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK61380.1 - 0.027 14.7 0.1 0.083 13.2 0.1 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Nramp PF01566.18 PIK61380.1 - 0.18 10.7 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Natural resistance-associated macrophage protein LIM PF00412.22 PIK61381.1 - 5.7e-30 103.3 15.0 9.6e-15 54.6 5.6 2.5 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 PIK61381.1 - 2.2e-15 56.2 0.2 4.1e-15 55.4 0.2 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK61381.1 - 4.1e-05 23.4 0.0 8.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain NinD PF17466.2 PIK61381.1 - 0.14 12.2 3.6 3.5 7.8 0.4 2.7 2 0 0 2 2 2 0 Family of unknown function LRRC37 PF15779.5 PIK61381.1 - 3.4 8.1 8.1 0.64 10.4 4.3 1.7 2 0 0 2 2 2 0 Leucine-rich repeat-containing protein 37 family Lectin_C PF00059.21 PIK61382.1 - 5e-17 62.6 0.6 3.1e-16 60.0 0.6 1.9 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK61382.1 - 6.2e-05 22.7 0.0 8e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like FAM91_N PF14647.6 PIK61382.1 - 0.055 12.8 0.0 0.066 12.5 0.0 1.1 1 0 0 1 1 1 0 FAM91 N-terminus Lectin_C PF00059.21 PIK61383.1 - 3.9e-15 56.5 0.1 7.4e-14 52.4 0.1 2.2 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK61383.1 - 0.0053 16.4 0.0 0.0069 16.0 0.0 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Cu2_monoox_C PF03712.15 PIK61384.1 - 4e-39 133.6 0.0 5.5e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 PIK61384.1 - 3.9e-18 65.9 0.0 6.6e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Pkinase_Tyr PF07714.17 PIK61385.1 - 8.3e-86 287.4 0.0 1.1e-85 287.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61385.1 - 8e-42 143.4 0.0 1.2e-41 142.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK61385.1 - 3.1e-23 81.7 0.3 7.4e-23 80.5 0.3 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK61385.1 - 2.2e-10 40.0 0.0 4e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK61385.1 - 2.5e-06 27.1 0.0 7.5e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK61385.1 - 8.1e-05 22.4 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.6 PIK61385.1 - 0.0017 17.7 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK61385.1 - 0.0019 17.1 0.0 0.003 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 PIK61385.1 - 0.021 14.4 0.1 0.042 13.4 0.1 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 PIK61385.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CCHC PF00098.23 PIK61386.1 - 8.9e-06 25.6 54.9 0.0033 17.4 1.2 6.2 6 0 0 6 6 6 4 Zinc knuckle zf-CCHC_5 PF14787.6 PIK61386.1 - 0.01 15.5 0.9 0.01 15.5 0.9 5.7 6 0 0 6 6 6 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 PIK61386.1 - 0.049 13.6 0.3 0.049 13.6 0.3 5.6 4 1 2 6 6 6 0 Zinc knuckle CENP-B_dimeris PF09026.10 PIK61386.1 - 4.7 7.6 7.0 5.7 7.4 2.4 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PID PF00640.23 PIK61387.1 - 4.3e-34 117.5 0.0 6.4e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 PIK61387.1 - 6.1e-17 61.5 0.0 1.1e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Pepdidase_M14_N PF18027.1 PIK61388.1 - 4.5e-14 52.7 2.0 1.3e-13 51.3 2.0 1.8 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain NinD PF17466.2 PIK61388.1 - 0.44 10.7 1.7 11 6.2 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function Sigma70_ner PF04546.13 PIK61388.1 - 2.8 7.8 4.8 4.7 7.0 4.8 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region E3_UbLigase_R4 PF13764.6 PIK61389.1 - 0.022 13.0 1.4 1.4 7.0 0.3 2.0 1 1 1 2 2 2 0 E3 ubiquitin-protein ligase UBR4 Ly-6_related PF06579.12 PIK61390.1 - 0.00014 22.1 1.7 0.00019 21.7 1.7 1.2 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein UPAR_LY6 PF00021.21 PIK61390.1 - 0.28 11.9 8.7 3.6 8.3 8.7 2.4 1 1 0 1 1 1 0 u-PAR/Ly-6 domain Cep57_CLD PF14073.6 PIK61391.1 - 0.00019 21.5 13.8 0.00019 21.5 13.8 2.0 1 1 1 2 2 1 1 Centrosome localisation domain of Cep57 CENP-F_leu_zip PF10473.9 PIK61391.1 - 0.00036 20.6 26.0 0.001 19.1 24.5 2.0 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JAKMIP_CC3 PF16034.5 PIK61391.1 - 0.00071 19.6 17.5 0.012 15.6 17.5 2.2 1 1 0 1 1 1 1 JAKMIP CC3 domain DUF2312 PF10073.9 PIK61391.1 - 0.0038 16.8 7.0 0.11 12.1 0.7 2.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2312) BST2 PF16716.5 PIK61391.1 - 0.0054 17.3 5.8 0.0054 17.3 5.8 2.6 2 1 1 3 3 2 1 Bone marrow stromal antigen 2 DUF4972 PF16342.5 PIK61391.1 - 0.011 15.5 6.0 0.039 13.7 5.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4972) YscO PF07321.12 PIK61391.1 - 0.016 15.2 6.9 0.016 15.2 6.9 2.2 1 1 0 2 2 2 0 Type III secretion protein YscO Borrelia_P83 PF05262.11 PIK61391.1 - 0.04 12.4 14.4 0.046 12.2 14.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Mito_fiss_reg PF05308.11 PIK61391.1 - 0.046 13.8 6.0 0.05 13.7 5.2 1.4 1 1 0 1 1 1 0 Mitochondrial fission regulator Spc7 PF08317.11 PIK61391.1 - 0.063 12.2 20.8 0.059 12.3 19.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.12 PIK61391.1 - 0.072 13.1 12.0 0.098 12.7 3.9 1.9 1 1 1 2 2 2 0 Laminin Domain II XLF PF09302.11 PIK61391.1 - 0.077 13.2 10.9 0.51 10.5 2.1 2.3 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component CENP-H PF05837.12 PIK61391.1 - 0.084 13.3 15.8 0.053 13.9 13.0 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1722 PF08349.11 PIK61391.1 - 0.091 13.1 4.4 0.071 13.4 2.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1722) Syntaxin-6_N PF09177.11 PIK61391.1 - 0.12 13.0 13.9 4.1 8.0 12.5 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal LPP PF04728.13 PIK61391.1 - 0.12 12.8 10.5 6.6 7.2 1.5 3.7 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Fez1 PF06818.15 PIK61391.1 - 0.15 12.5 19.0 0.23 11.9 14.1 2.1 1 1 1 2 2 2 0 Fez1 FapA PF03961.13 PIK61391.1 - 0.16 10.5 20.6 0.12 10.9 7.6 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A Filament PF00038.21 PIK61391.1 - 0.17 11.4 22.2 1.5 8.3 9.4 2.3 1 1 1 2 2 2 0 Intermediate filament protein Glycohydro_20b2 PF14845.6 PIK61391.1 - 0.2 12.3 4.3 0.37 11.5 4.3 1.5 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like Phasin PF05597.11 PIK61391.1 - 0.24 11.4 10.1 0.42 10.6 8.8 1.9 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4407 PF14362.6 PIK61391.1 - 0.26 10.6 10.2 0.33 10.3 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 PIK61391.1 - 0.26 11.3 13.3 0.64 10.1 8.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PKcGMP_CC PF16808.5 PIK61391.1 - 0.28 11.1 10.5 2.1 8.3 1.4 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Atg14 PF10186.9 PIK61391.1 - 0.33 10.0 16.5 2.5 7.1 16.5 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 PIK61391.1 - 0.36 11.4 25.9 0.058 13.9 19.4 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region FliJ PF02050.16 PIK61391.1 - 0.39 11.0 21.5 3.3 7.9 18.5 2.7 1 1 1 2 2 2 0 Flagellar FliJ protein DUF4391 PF14335.6 PIK61391.1 - 0.45 10.2 10.5 0.17 11.6 2.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4391) Csm1_N PF18504.1 PIK61391.1 - 0.49 10.8 18.5 0.082 13.3 2.9 4.0 2 1 2 4 4 3 0 Csm1 N-terminal domain Sod_Ni PF09055.11 PIK61391.1 - 0.53 10.9 4.1 1.4 9.5 2.4 2.2 1 1 1 2 2 2 0 Nickel-containing superoxide dismutase DUF724 PF05266.14 PIK61391.1 - 0.55 10.0 15.0 0.21 11.4 12.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) ApoO PF09769.9 PIK61391.1 - 0.7 9.9 3.1 3.5 7.6 0.3 2.3 1 1 1 2 2 2 0 Apolipoprotein O DUF4140 PF13600.6 PIK61391.1 - 0.72 10.3 17.7 4.8 7.7 0.5 3.4 2 1 2 4 4 3 0 N-terminal domain of unknown function (DUF4140) Sec34 PF04136.15 PIK61391.1 - 0.81 9.6 12.7 0.11 12.4 3.2 2.4 1 1 1 2 2 2 0 Sec34-like family Fzo_mitofusin PF04799.13 PIK61391.1 - 0.9 9.1 9.9 0.98 9.0 7.9 2.0 1 1 1 2 2 2 0 fzo-like conserved region TraF_2 PF13729.6 PIK61391.1 - 0.94 8.8 9.3 2.9 7.2 3.2 2.2 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein Tho2 PF11262.8 PIK61391.1 - 0.95 8.6 10.3 0.2 10.8 6.4 1.6 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 NPV_P10 PF05531.12 PIK61391.1 - 1 9.8 11.3 10 6.7 1.3 3.4 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein GIT_CC PF16559.5 PIK61391.1 - 1.1 9.2 10.1 17 5.3 0.1 3.4 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlxA PF14282.6 PIK61391.1 - 1.4 9.0 17.9 6.3 6.9 13.7 2.7 1 1 1 2 2 2 0 FlxA-like protein Histone_HNS PF00816.21 PIK61391.1 - 1.4 9.7 6.8 0.16 12.8 1.8 1.9 2 0 0 2 2 1 0 H-NS histone family Prominin PF05478.11 PIK61391.1 - 1.5 6.7 8.8 1.6 6.6 8.8 1.1 1 0 0 1 1 1 0 Prominin TolA_bind_tri PF16331.5 PIK61391.1 - 1.5 9.0 24.9 0.69 10.0 6.2 4.0 1 1 3 4 4 4 0 TolA binding protein trimerisation UPF0242 PF06785.11 PIK61391.1 - 1.7 8.7 25.2 0.23 11.6 18.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1192 PF06698.11 PIK61391.1 - 1.9 8.6 8.8 1.4 9.0 1.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) DivIC PF04977.15 PIK61391.1 - 2.2 8.1 18.4 2.4 8.0 2.7 3.8 2 1 2 4 4 4 0 Septum formation initiator MutS_IV PF05190.18 PIK61391.1 - 2.5 8.5 12.2 5.7 7.3 0.5 3.3 1 1 3 4 4 3 0 MutS family domain IV TMF_DNA_bd PF12329.8 PIK61391.1 - 2.7 8.0 23.7 1.6 8.8 6.9 3.9 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF745 PF05335.13 PIK61391.1 - 2.9 7.6 11.4 3.7 7.2 10.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Fib_alpha PF08702.10 PIK61391.1 - 3 8.0 14.5 3.6 7.8 13.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 PIK61391.1 - 3.2 7.2 14.0 6 6.3 14.0 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit HalX PF08663.10 PIK61391.1 - 3.3 8.1 16.9 0.33 11.3 3.3 3.4 1 1 2 3 3 3 0 HalX domain SlyX PF04102.12 PIK61391.1 - 3.7 8.2 20.0 1.2 9.8 7.3 3.8 2 1 2 4 4 4 0 SlyX DUF948 PF06103.11 PIK61391.1 - 3.8 7.8 7.1 39 4.6 5.7 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ERM PF00769.19 PIK61391.1 - 3.8 7.2 24.3 15 5.3 24.4 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family IL2 PF00715.17 PIK61391.1 - 4.7 7.1 7.3 5.1 7.0 1.6 2.5 1 1 1 2 2 2 0 Interleukin 2 DUF4988 PF16378.5 PIK61391.1 - 4.7 6.8 8.6 7.2 6.2 4.8 2.7 2 1 0 2 2 2 0 Domain of unknown function CASP_C PF08172.12 PIK61391.1 - 4.8 6.5 16.0 0.63 9.3 2.7 2.6 1 1 0 2 2 2 0 CASP C terminal DUF2203 PF09969.9 PIK61391.1 - 4.8 7.9 12.7 3.7 8.3 4.0 2.4 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) FlaC_arch PF05377.11 PIK61391.1 - 4.9 7.6 16.5 4.6 7.7 6.6 4.0 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) Allexi_40kDa PF05549.11 PIK61391.1 - 5 6.5 8.7 3.3 7.1 5.4 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein TMPIT PF07851.13 PIK61391.1 - 5.5 6.1 11.7 7.9 5.6 11.2 1.4 1 1 0 1 1 1 0 TMPIT-like protein DUF16 PF01519.16 PIK61391.1 - 5.6 7.5 17.0 12 6.4 3.9 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 LUC7 PF03194.15 PIK61391.1 - 5.8 6.5 15.1 11 5.6 15.1 1.5 1 1 0 1 1 1 0 LUC7 N_terminus Smac_DIABLO PF09057.10 PIK61391.1 - 5.9 6.2 11.6 0.18 11.2 2.4 2.2 1 1 1 2 2 2 0 Second Mitochondria-derived Activator of Caspases DUF883 PF05957.13 PIK61391.1 - 7.5 7.2 9.8 1.5 9.5 3.1 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ACCA PF03255.14 PIK61391.1 - 9.1 6.1 12.7 1.4 8.8 4.8 2.4 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CorA PF01544.18 PIK61391.1 - 9.9 5.4 13.0 6.5 6.0 11.1 1.6 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein VWA_2 PF13519.6 PIK61392.1 - 1e-08 35.7 0.0 6.6e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain TBCA PF02970.16 PIK61393.1 - 1.4e-21 76.6 7.0 1.7e-21 76.4 7.0 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF3741 PF12552.8 PIK61393.1 - 0.0097 15.8 0.1 0.019 14.9 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3741) TFA2_Winged_2 PF18121.1 PIK61393.1 - 0.21 11.3 1.3 0.97 9.2 0.1 2.4 2 1 0 2 2 2 0 TFA2 Winged helix domain 2 DUF4355 PF14265.6 PIK61393.1 - 1.7 8.9 8.7 2.7 8.2 3.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Homeodomain PF00046.29 PIK61394.1 - 1.4e-14 53.7 0.2 2.1e-14 53.1 0.2 1.2 1 0 0 1 1 1 1 Homeodomain S36_mt PF10937.8 PIK61395.1 - 7.8e-07 30.7 0.0 9.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Rgp1 PF08737.10 PIK61396.1 - 5.8e-40 137.7 0.2 1.6e-21 77.0 0.1 2.3 1 1 1 2 2 2 2 Rgp1 RT_RNaseH_2 PF17919.1 PIK61397.1 - 1.2e-32 111.9 0.1 4.4e-32 110.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK61397.1 - 1.3e-28 99.3 0.0 3.9e-28 97.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK61397.1 - 1.6e-18 67.0 0.0 3.3e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK61397.1 - 1.4e-14 53.9 0.1 4.1e-14 52.4 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK61397.1 - 0.0022 18.2 0.9 0.066 13.4 0.0 3.6 4 0 0 4 4 4 1 H2C2 zinc finger zf-CCHC PF00098.23 PIK61397.1 - 0.6 10.3 9.4 0.024 14.7 2.4 2.5 2 0 0 2 2 2 0 Zinc knuckle TrmO PF01980.16 PIK61398.1 - 1.2e-43 148.1 0.0 2.1e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 PIK61398.1 - 0.00024 21.2 0.0 0.0013 18.8 0.0 2.1 1 1 0 1 1 1 1 TrmO C-terminal domain NYD-SP28 PF14772.6 PIK61399.1 - 0.024 14.7 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Sperm tail TSP_C PF05735.12 PIK61400.1 - 4e-90 301.1 0.8 5.5e-90 300.6 0.8 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 PIK61400.1 - 1e-50 169.1 118.9 3.2e-11 42.7 11.0 9.3 7 2 1 8 8 8 7 Thrombospondin type 3 repeat EGF_CA PF07645.15 PIK61400.1 - 1.7e-08 34.6 19.8 1.2e-05 25.4 10.1 6.5 7 0 0 7 7 7 3 Calcium-binding EGF domain COMP PF11598.8 PIK61400.1 - 0.0063 17.0 2.4 0.012 16.1 2.4 1.4 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_3 PF12947.7 PIK61400.1 - 0.015 15.4 9.4 0.015 15.4 9.4 6.5 6 0 0 6 6 6 0 EGF domain cEGF PF12662.7 PIK61400.1 - 0.28 11.1 0.1 0.035 14.1 4.1 7.9 8 0 0 8 8 8 0 Complement Clr-like EGF-like TORC_M PF12885.7 PIK61402.1 - 1.6e-25 89.9 2.7 1.6e-25 89.9 2.7 2.4 2 1 0 2 2 2 1 Transducer of regulated CREB activity middle domain Ndc1_Nup PF09531.10 PIK61402.1 - 1.6 7.3 9.0 2.4 6.7 9.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PA28_beta PF02252.18 PIK61403.1 - 2.5e-59 199.1 0.1 4.1e-59 198.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 PIK61403.1 - 7.9e-09 35.4 0.6 1.6e-08 34.5 0.6 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit NUFIP2 PF15293.6 PIK61403.1 - 0.2 10.5 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Spindle_Spc25 PF08234.12 PIK61404.1 - 5.1e-24 84.3 0.7 1.1e-23 83.3 0.7 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 EMP24_GP25L PF01105.24 PIK61404.1 - 0.033 14.1 0.3 0.033 14.1 0.3 2.9 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD Folliculin PF11704.8 PIK61404.1 - 0.16 11.9 7.2 1.3 8.9 6.4 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Es2 PF09751.9 PIK61404.1 - 0.21 11.3 8.9 0.28 10.9 8.9 1.2 1 0 0 1 1 1 0 Nuclear protein Es2 Spc7 PF08317.11 PIK61404.1 - 0.25 10.2 23.8 0.54 9.1 23.8 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 PIK61404.1 - 0.39 10.9 0.2 0.39 10.9 0.2 3.4 2 1 2 4 4 4 0 Haemolysin XhlA DUF948 PF06103.11 PIK61404.1 - 0.67 10.3 4.6 0.92 9.8 1.2 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DASH_Spc34 PF08657.10 PIK61404.1 - 1.3 8.8 14.1 2 8.1 14.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 PDT PF00800.18 PIK61404.1 - 3.5 7.4 9.7 3.2 7.5 8.0 1.8 1 1 1 2 2 2 0 Prephenate dehydratase Exonuc_VII_L PF02601.15 PIK61404.1 - 3.8 7.0 19.4 4.8 6.7 19.3 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF3573 PF12097.8 PIK61404.1 - 5.9 5.6 6.5 8 5.2 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) PH PF00169.29 PIK61405.1 - 5.3e-10 39.7 0.7 5.3e-10 39.7 0.7 2.8 3 0 0 3 3 3 1 PH domain RA PF00788.23 PIK61405.1 - 2.7e-08 34.3 1.0 1.6e-07 31.8 0.1 2.6 2 1 1 3 3 3 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.6 PIK61405.1 - 1.3 9.4 6.9 16 6.0 5.7 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain ATG27 PF09451.10 PIK61406.1 - 3.8e-18 66.3 2.0 6.2e-18 65.6 2.0 1.3 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 PIK61406.1 - 1.9e-13 50.1 0.4 4.6e-13 48.8 0.4 1.6 1 1 0 1 1 1 1 Mannose-6-phosphate receptor Man-6-P_recep PF02157.15 PIK61407.1 - 5.8e-19 68.2 0.1 8.3e-19 67.7 0.1 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 PIK61407.1 - 2.3e-17 63.7 0.3 3.3e-17 63.2 0.3 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Peptidase_C48 PF02902.19 PIK61408.1 - 2.6e-29 102.6 2.2 4.4e-29 101.9 2.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 PIK61408.1 - 4.8e-05 22.3 1.3 0.00074 18.3 0.1 2.3 1 1 1 2 2 2 2 Vaccinia virus I7 processing peptidase Peptidase_C5 PF00770.18 PIK61408.1 - 0.041 13.6 0.1 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 Adenovirus endoprotease APH PF01636.23 PIK61409.1 - 7.7e-07 29.3 0.0 1.2e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4427 PF14468.6 PIK61409.1 - 0.038 14.1 0.0 0.36 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4427) Choline_kinase PF01633.20 PIK61409.1 - 0.044 13.4 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 PIK61410.1 - 2.1e-12 47.5 0.0 2.9e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 PIK61410.1 - 0.00063 19.1 0.1 0.00072 19.0 0.1 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 PIK61410.1 - 0.11 11.8 0.3 0.28 10.5 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Longin PF13774.6 PIK61411.1 - 2.5e-16 59.5 0.0 5.3e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF2975 PF11188.8 PIK61411.1 - 0.0067 16.3 0.7 0.013 15.4 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2975) Bac_export_1 PF01311.20 PIK61411.1 - 0.056 13.0 3.6 0.48 9.9 3.5 2.1 1 1 1 2 2 2 0 Bacterial export proteins, family 1 Actin PF00022.19 PIK61412.1 - 3.1e-53 180.8 0.0 3.7e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 PIK61413.1 - 5.1e-38 130.8 0.0 5.5e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Actin 7tm_1 PF00001.21 PIK61414.1 - 2e-30 106.0 8.9 2.8e-30 105.5 8.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK61414.1 - 1.6e-07 31.3 13.2 2e-07 30.9 13.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK61414.1 - 1.1e-06 28.2 5.8 1.1e-06 28.2 5.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv NPCC PF08058.11 PIK61414.1 - 0.12 12.5 1.4 0.52 10.4 0.1 2.2 2 1 0 2 2 2 0 Nuclear pore complex component DUF3671 PF12420.8 PIK61414.1 - 0.42 10.7 4.6 1 9.4 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function 7TM_GPCR_Srsx PF10320.9 PIK61414.1 - 0.49 9.7 15.5 3.2 7.1 15.5 2.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Rap_GAP PF02145.15 PIK61415.1 - 5e-46 156.6 0.0 1e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Arm_2 PF04826.13 PIK61415.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Armadillo-like YqfQ PF14181.6 PIK61415.1 - 0.074 13.2 4.3 0.19 11.9 4.3 1.7 1 0 0 1 1 1 0 YqfQ-like protein Hydrolase_4 PF12146.8 PIK61417.1 - 6.9e-16 58.2 0.1 1.3e-12 47.5 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 PIK61417.1 - 2e-14 53.8 0.1 3.1e-11 43.4 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 PIK61417.1 - 5.4e-08 33.7 0.0 1.1e-07 32.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 PIK61417.1 - 8.9e-06 25.7 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 PIK61417.1 - 0.0001 21.8 0.0 0.00025 20.6 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.25 PIK61417.1 - 0.00018 21.4 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Peptidase_S15 PF02129.18 PIK61417.1 - 0.0035 17.0 0.0 0.095 12.3 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) LIDHydrolase PF10230.9 PIK61417.1 - 0.015 14.8 0.0 0.035 13.6 0.0 1.6 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Say1_Mug180 PF10340.9 PIK61417.1 - 0.045 12.6 0.0 0.073 11.9 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 PIK61417.1 - 0.17 10.8 0.0 0.36 9.7 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase enzyme Ras PF00071.22 PIK61418.1 - 1.7e-17 63.5 0.0 2.4e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK61418.1 - 2.2e-07 31.1 0.0 3e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 PIK61418.1 - 0.081 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 PIK61418.1 - 0.21 11.1 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Ras PF00071.22 PIK61419.1 - 2.5e-14 53.2 0.0 3.1e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK61419.1 - 0.0059 16.8 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Lipase_GDSL_3 PF14606.6 PIK61419.1 - 0.014 15.6 0.1 0.02 15.1 0.1 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family RPAP1_C PF08620.10 PIK61421.1 - 1.2e-25 89.4 0.1 2.7e-25 88.2 0.1 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 PIK61421.1 - 4e-14 52.1 4.2 1.1e-13 50.7 4.2 1.8 1 0 0 1 1 1 1 RPAP1-like, N-terminal PP2C PF00481.21 PIK61422.1 - 2.2e-76 256.9 0.0 2.8e-76 256.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 PIK61422.1 - 5.5e-22 78.0 0.1 1.2e-21 76.9 0.1 1.6 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain SpoIIE PF07228.12 PIK61422.1 - 2e-06 27.9 0.0 0.079 12.9 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 PIK61422.1 - 0.033 13.8 0.0 0.18 11.4 0.0 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C DUF3456 PF11938.8 PIK61422.1 - 0.19 12.2 0.0 0.39 11.2 0.0 1.4 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP 2OG-FeII_Oxy_2 PF13532.6 PIK61423.1 - 1.2e-13 51.7 0.0 1e-12 48.7 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 PIK61423.1 - 0.0036 17.7 0.4 0.0099 16.4 0.2 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Lectin_C PF00059.21 PIK61424.1 - 6.2e-11 43.0 0.0 9.8e-11 42.4 0.0 1.4 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK61424.1 - 6.8e-05 22.6 0.0 9.2e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like SAUGI PF06106.11 PIK61424.1 - 0.035 14.6 0.0 0.051 14.1 0.0 1.2 1 0 0 1 1 1 0 S. aureus uracil DNA glycosylase inhibitor EGF PF00008.27 PIK61425.1 - 2.1e-56 187.8 267.1 5.9e-08 32.9 5.7 19.7 20 0 0 20 20 20 15 EGF-like domain hEGF PF12661.7 PIK61425.1 - 5.2e-07 30.1 30.9 6.1e-05 23.5 7.8 21.5 19 2 0 19 19 19 11 Human growth factor-like EGF VWC PF00093.18 PIK61425.1 - 5.3e-05 23.5 5.1 5.3e-05 23.5 5.1 15.5 4 3 9 13 13 13 4 von Willebrand factor type C domain Pacifastin_I PF05375.13 PIK61425.1 - 0.0019 17.9 6.5 0.0019 17.9 6.5 10.9 12 1 1 13 13 13 4 Pacifastin inhibitor (LCMII) EGF_CA PF07645.15 PIK61425.1 - 0.005 17.0 5.8 0.005 17.0 5.8 19.4 11 3 9 20 20 20 4 Calcium-binding EGF domain ECSCR PF15820.5 PIK61425.1 - 0.14 12.0 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EGF_2 PF07974.13 PIK61425.1 - 3.8 8.0 278.0 0.056 13.8 6.5 19.7 17 2 2 19 19 19 0 EGF-like domain ERG4_ERG24 PF01222.17 PIK61427.1 - 3.3e-56 190.9 1.7 3.6e-56 190.8 1.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.14 PIK61427.1 - 0.00052 20.4 0.0 0.00074 19.9 0.0 1.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.12 PIK61427.1 - 0.0031 17.1 0.1 0.0036 16.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 PIK61427.1 - 0.0073 16.7 0.0 0.0097 16.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.16 PIK61427.1 - 0.025 14.6 0.2 0.028 14.4 0.2 1.2 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase ERG4_ERG24 PF01222.17 PIK61428.1 - 4.8e-55 187.0 7.4 1.8e-54 185.2 7.4 1.6 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor PF09465.10 PIK61428.1 - 5.5e-14 51.7 0.0 1.8e-13 50.0 0.1 1.8 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain Tudor_3 PF18115.1 PIK61428.1 - 4.8e-05 23.1 0.0 9.6e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF1325 PF07039.11 PIK61428.1 - 0.0049 17.0 0.0 0.0097 16.0 0.0 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain Agenet PF05641.12 PIK61428.1 - 0.033 14.6 0.1 0.27 11.7 0.0 2.3 2 0 0 2 2 2 0 Agenet domain 53-BP1_Tudor PF09038.10 PIK61428.1 - 0.072 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor SdrG_C_C PF10425.9 PIK61428.1 - 0.09 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 C-terminus of bacterial fibrinogen-binding adhesin 7TMR-DISM_7TM PF07695.11 PIK61428.1 - 3.2 7.6 16.9 0.12 12.3 11.1 1.6 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF2207 PF09972.9 PIK61428.1 - 5.2 5.7 8.6 4.1 6.1 0.0 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) ASXH PF13919.6 PIK61429.1 - 5.1e-35 120.5 5.8 2.5e-34 118.3 1.3 2.5 2 0 0 2 2 2 2 Asx homology domain PHD_3 PF13922.6 PIK61429.1 - 3.4e-14 53.0 10.1 1.5e-13 50.9 10.1 2.2 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx XK-related PF09815.9 PIK61430.1 - 2e-73 247.4 23.7 2.3e-73 247.2 23.7 1.1 1 0 0 1 1 1 1 XK-related protein Sugar_tr PF00083.24 PIK61431.1 - 3.4e-87 293.2 23.2 6e-71 239.6 14.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK61431.1 - 6.8e-25 87.7 33.4 4.1e-23 81.9 24.1 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 PIK61431.1 - 2.2e-05 23.1 3.7 2.2e-05 23.1 3.7 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 PIK61431.1 - 0.026 12.9 9.7 0.17 10.2 1.3 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector DUF1071 PF06378.11 PIK61431.1 - 0.15 11.6 0.2 0.76 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1071) Fibrinogen_C PF00147.18 PIK61432.1 - 4e-112 373.4 24.1 2.7e-43 148.3 10.0 3.1 3 0 0 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK61432.1 - 0.0031 17.7 9.4 0.0031 17.7 9.4 5.4 5 1 1 6 6 6 2 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK61432.1 - 0.0053 16.9 18.1 0.0084 16.3 6.7 5.8 5 0 0 5 5 5 2 EGF domain Fibrinogen_C PF00147.18 PIK61433.1 - 1.5e-89 299.5 25.3 2.2e-51 174.8 10.1 4.1 4 0 0 4 4 4 4 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK61433.1 - 9e-07 29.0 17.1 1.4e-05 25.1 5.3 5.0 5 0 0 5 5 5 2 EGF domain TIL PF01826.17 PIK61433.1 - 0.00043 20.5 12.7 0.00043 20.5 12.7 5.3 4 2 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Fibrinogen_C PF00147.18 PIK61434.1 - 3.5e-88 295.1 17.5 1.9e-52 178.2 12.3 3.2 2 1 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK61434.1 - 0.00011 22.4 8.5 0.00011 22.4 8.5 4.1 4 1 1 5 5 5 1 EGF domain Fibrinogen_C PF00147.18 PIK61435.1 - 1.4e-28 100.2 22.8 2.3e-20 73.4 2.7 3.1 1 1 2 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61436.1 - 4e-22 79.1 0.8 4.8e-07 29.8 0.0 3.1 3 0 0 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK61436.1 - 8.7e-06 25.8 5.9 8.7e-06 25.8 5.9 3.7 4 0 0 4 4 4 1 EGF domain TILa PF12714.7 PIK61436.1 - 1.5 8.9 17.1 0.038 13.9 7.9 2.8 1 1 0 2 2 2 0 TILa domain EGF_2 PF07974.13 PIK61436.1 - 2.5 8.6 13.2 2.5 8.5 6.8 3.3 2 1 0 2 2 2 0 EGF-like domain Fibrinogen_C PF00147.18 PIK61437.1 - 1.8e-57 194.7 19.4 3.9e-53 180.5 7.2 4.2 3 1 1 4 4 4 3 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK61437.1 - 2.2e-29 101.1 99.2 2.5e-06 27.3 4.2 9.6 7 1 1 8 8 8 7 TILa domain EGF_3 PF12947.7 PIK61437.1 - 7.9e-29 99.6 166.7 5.1e-06 26.6 9.2 13.8 12 3 3 15 15 15 7 EGF domain EGF_2 PF07974.13 PIK61437.1 - 5.7e-09 36.2 122.0 0.058 13.8 8.0 10.5 9 1 0 9 9 9 7 EGF-like domain EGF_MSP1_1 PF12946.7 PIK61437.1 - 1.2e-06 28.5 104.7 0.058 13.5 3.8 10.6 12 0 0 12 12 12 7 MSP1 EGF domain 1 GCN5L1 PF06320.13 PIK61437.1 - 0.0061 16.7 0.1 65 3.7 0.0 4.8 5 0 0 5 5 5 0 GCN5-like protein 1 (GCN5L1) EGF PF00008.27 PIK61437.1 - 0.044 14.1 97.4 0.27 11.6 4.0 10.4 9 0 0 9 9 9 0 EGF-like domain Acyltransferase PF01553.21 PIK61438.1 - 4.4e-17 62.0 0.0 9e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 PIK61438.1 - 4.3e-16 58.8 0.0 1.6e-15 56.9 0.0 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus DUF2724 PF10893.8 PIK61438.1 - 0.18 11.7 0.4 10 6.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) 3HCDH PF00725.22 PIK61439.1 - 5e-08 33.4 0.0 0.0061 17.2 0.0 2.3 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 PIK61440.1 - 2e-35 122.3 1.7 2.3e-35 122.1 1.7 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 PIK61441.1 - 3.4e-12 46.2 0.0 5e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH_N PF02737.18 PIK61441.1 - 2.3e-06 27.6 2.7 4e-06 26.8 0.6 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_2 PF16113.5 PIK61441.1 - 0.00018 21.1 0.0 0.00025 20.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 PIK61442.1 - 5.8e-16 58.6 0.2 6.8e-16 58.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK61442.1 - 1.4e-09 37.9 0.0 1.8e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SKIP_SNW PF02731.15 PIK61443.1 - 3.8e-57 192.5 7.2 1e-54 184.5 7.2 2.7 1 1 0 1 1 1 1 SKIP/SNW domain Not3 PF04065.15 PIK61443.1 - 0.1 12.0 9.0 0.055 12.9 6.6 1.7 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Gly_radical PF01228.21 PIK61443.1 - 0.12 12.9 0.4 0.4 11.2 0.4 1.8 1 0 0 1 1 1 0 Glycine radical ABC1 PF03109.16 PIK61444.1 - 4.5e-38 130.1 0.1 9e-38 129.1 0.1 1.5 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 PIK61444.1 - 1.5e-05 24.5 0.1 0.00041 19.8 0.1 2.3 2 1 0 2 2 2 1 Protein kinase domain FTR1 PF03239.14 PIK61444.1 - 0.027 13.6 0.1 0.049 12.8 0.1 1.3 1 0 0 1 1 1 0 Iron permease FTR1 family APH PF01636.23 PIK61444.1 - 0.041 13.8 0.2 0.58 10.0 0.4 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family ThiF PF00899.21 PIK61445.1 - 4.5e-51 173.6 0.0 1.1e-25 90.4 0.1 2.1 1 1 1 2 2 2 2 ThiF family Rhodanese PF00581.20 PIK61445.1 - 1.8e-05 25.2 0.0 5.5e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain UDPG_MGDP_dh_N PF03721.14 PIK61445.1 - 0.011 15.3 0.1 0.018 14.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 PIK61445.1 - 0.096 12.7 0.0 0.25 11.4 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pellino PF04710.14 PIK61446.1 - 1.3e-199 663.0 0.0 1.7e-199 662.7 0.0 1.0 1 0 0 1 1 1 1 Pellino DUF772 PF05598.11 PIK61446.1 - 0.11 12.5 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Transposase domain (DUF772) zf-RING_2 PF13639.6 PIK61446.1 - 0.13 12.6 0.2 0.13 12.6 0.2 3.1 3 0 0 3 3 3 0 Ring finger domain zf-RING_5 PF14634.6 PIK61446.1 - 0.14 12.1 0.1 0.14 12.1 0.1 2.9 2 1 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 PIK61446.1 - 0.41 10.5 13.3 7.3 6.5 0.1 3.3 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 PIK61446.1 - 1.1 9.2 17.7 0.32 10.9 4.9 3.3 3 2 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C4 PF00105.18 PIK61447.1 - 3.6e-24 85.0 13.7 8.6e-24 83.8 13.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK61447.1 - 6.4e-12 45.5 0.2 2.2e-11 43.8 0.2 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Aldose_epim PF01263.20 PIK61448.1 - 6.7e-93 311.3 0.0 7.6e-93 311.1 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase TAF1_subA PF14929.6 PIK61449.1 - 9e-41 140.5 2.4 1.2e-40 140.1 2.4 1.1 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A TPR_14 PF13428.6 PIK61449.1 - 7.9e-05 23.2 0.1 0.17 12.8 0.1 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61449.1 - 0.003 17.7 1.5 0.032 14.4 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61449.1 - 0.0039 17.2 2.0 0.34 11.1 0.4 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61449.1 - 0.0046 16.7 2.3 0.12 12.2 0.4 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61449.1 - 0.012 16.1 0.0 0.72 10.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK61449.1 - 0.064 13.9 0.6 0.6 10.9 0.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 PIK61449.1 - 0.099 12.5 0.2 0.91 9.4 0.0 2.5 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 PIK61449.1 - 0.45 10.8 2.0 2.7 8.3 0.1 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 PIK61450.1 - 7.9e-08 32.7 3.2 1.3e-07 32.0 2.6 1.7 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 PIK61450.1 - 1.6e-07 30.7 0.3 0.00075 19.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 PIK61450.1 - 0.00085 18.7 5.6 0.044 13.3 0.0 3.1 4 0 0 4 4 4 2 EF hand TFIIA PF03153.13 PIK61450.1 - 0.0016 18.5 16.9 0.0023 18.0 16.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 PIK61450.1 - 0.0042 15.8 20.5 0.0046 15.7 20.5 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal ECM1 PF05782.11 PIK61450.1 - 0.13 11.2 5.7 0.16 10.9 5.7 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) EF-hand_5 PF13202.6 PIK61450.1 - 0.13 11.8 0.1 0.13 11.8 0.1 2.1 3 0 0 3 3 3 0 EF hand UPF0560 PF10577.9 PIK61450.1 - 0.35 9.3 10.0 0.4 9.1 10.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 ExbD PF02472.16 PIK61450.1 - 1.1 9.4 11.4 1.7 8.8 10.8 1.4 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DOR PF14839.6 PIK61450.1 - 2.9 7.8 9.3 4.3 7.2 9.3 1.2 1 0 0 1 1 1 0 DOR family CLN3 PF02487.17 PIK61450.1 - 4.1 6.3 5.0 5.4 6.0 5.0 1.1 1 0 0 1 1 1 0 CLN3 protein Homeodomain PF00046.29 PIK61451.1 - 4.9e-22 77.5 4.6 9e-22 76.7 4.6 1.4 1 0 0 1 1 1 1 Homeodomain Ribosomal_60s PF00428.19 PIK61451.1 - 0.5 11.0 6.6 1 10.0 6.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Kelch_3 PF13415.6 PIK61452.1 - 1.5e-20 73.0 1.4 0.00031 21.0 0.0 5.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 PIK61452.1 - 1.9e-17 63.0 5.2 0.00089 19.2 0.0 5.5 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK61452.1 - 8.3e-17 60.8 6.1 0.0056 16.9 0.2 5.4 4 1 1 5 5 5 5 Kelch motif Kelch_1 PF01344.25 PIK61452.1 - 2.8e-15 55.6 7.3 0.0033 17.0 0.2 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 PIK61452.1 - 6.8e-14 51.5 8.6 2e-05 24.5 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 PIK61452.1 - 8.8e-14 50.8 11.7 0.0063 16.5 0.7 5.8 5 1 0 5 5 5 5 Kelch motif Arf PF00025.21 PIK61453.1 - 1.7e-24 86.2 0.0 2.2e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 PIK61453.1 - 0.00038 19.9 0.0 0.00049 19.6 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 PIK61453.1 - 0.024 14.3 0.0 0.031 13.9 0.0 1.1 1 0 0 1 1 1 0 Ras family Gtr1_RagA PF04670.12 PIK61453.1 - 0.049 13.0 0.0 0.059 12.7 0.0 1.2 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2316 PF10078.9 PIK61453.1 - 0.08 13.2 0.2 5.4 7.3 0.0 2.4 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) LTD PF00932.19 PIK61454.1 - 8e-06 26.2 1.5 0.0064 16.8 0.1 3.2 3 1 0 3 3 3 2 Lamin Tail Domain CarbopepD_reg_2 PF13715.6 PIK61454.1 - 0.16 11.9 0.6 19 5.3 0.0 3.4 4 0 0 4 4 4 0 CarboxypepD_reg-like domain DUF1495 PF07381.11 PIK61455.1 - 0.022 14.6 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) LTD PF00932.19 PIK61456.1 - 0.00025 21.3 0.5 0.59 10.5 0.2 2.5 2 0 0 2 2 2 2 Lamin Tail Domain Secretogranin_V PF05281.11 PIK61457.1 - 3.1e-05 23.7 4.6 0.00022 20.9 4.6 2.6 1 1 0 1 1 1 1 Neuroendocrine protein 7B2 precursor (Secretogranin V) VitD-bind_III PF09164.10 PIK61457.1 - 0.025 14.6 0.6 0.14 12.1 0.5 2.2 2 0 0 2 2 2 0 Vitamin D binding protein, domain III Steroid_dh PF02544.16 PIK61458.1 - 1.1e-58 197.4 2.0 2e-58 196.6 2.0 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 PIK61458.1 - 8.8e-07 28.7 0.2 2.1e-06 27.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF5090 PF17009.5 PIK61458.1 - 5.9 6.8 6.9 15 5.4 6.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5090) dCMP_cyt_deam_1 PF00383.23 PIK61459.1 - 0.047 13.6 0.1 0.098 12.6 0.1 1.5 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Galactosyl_T PF01762.21 PIK61460.1 - 1.6e-25 90.0 0.2 1.3e-23 83.9 0.1 2.2 2 0 0 2 2 2 2 Galactosyltransferase Fringe PF02434.16 PIK61460.1 - 0.023 14.1 0.8 0.047 13.1 0.8 1.5 1 0 0 1 1 1 0 Fringe-like HLH PF00010.26 PIK61461.1 - 2.5e-08 33.7 1.7 2.5e-08 33.7 1.7 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MRP_L53 PF10780.9 PIK61461.1 - 0.023 14.8 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 39S ribosomal protein L53/MRP-L53 zf-H2C2_2 PF13465.6 PIK61462.1 - 7e-62 203.3 93.8 7.4e-09 35.6 2.9 12.7 13 0 0 13 13 12 10 Zinc-finger double domain zf-C2H2 PF00096.26 PIK61462.1 - 3.5e-34 115.4 106.7 8.8e-06 25.9 1.7 12.9 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK61462.1 - 2.7e-27 93.1 100.4 0.00079 20.1 1.8 13.1 14 0 0 14 14 13 11 C2H2-type zinc finger Radical_SAM PF04055.21 PIK61462.1 - 3e-15 57.0 0.4 3e-15 57.0 0.4 5.0 4 2 0 4 4 3 1 Radical SAM superfamily zf-C2H2_jaz PF12171.8 PIK61462.1 - 2.7e-09 37.1 67.0 0.023 15.0 0.1 12.0 13 0 0 13 13 11 5 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 PIK61462.1 - 6.1e-06 26.6 32.4 0.025 14.9 0.6 5.8 6 0 0 6 6 6 3 zinc-finger-containing domain TRAM PF01938.20 PIK61462.1 - 4.1e-05 23.5 0.1 7.1e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 TRAM domain zf-C2H2_6 PF13912.6 PIK61462.1 - 0.0013 18.7 89.5 0.0022 17.9 1.3 11.8 12 0 0 12 12 12 6 C2H2-type zinc finger PyrI_C PF02748.15 PIK61462.1 - 0.0053 16.6 54.5 2.5 8.1 0.2 11.2 11 1 1 12 12 12 5 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 PIK61462.1 - 0.0073 16.7 0.3 0.0073 16.7 0.3 9.4 10 0 0 10 10 10 3 Zinc-finger of C2H2 type CpXC PF14353.6 PIK61462.1 - 0.48 10.5 0.0 0.48 10.5 0.0 6.4 4 1 2 7 7 7 0 CpXC protein BolA PF01722.18 PIK61462.1 - 0.63 10.4 6.1 25 5.2 0.1 4.3 2 1 1 4 4 4 0 BolA-like protein Bromodomain PF00439.25 PIK61463.1 - 3.5e-23 81.5 0.1 5.1e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 PIK61463.1 - 1.2e-08 34.7 10.3 2.4e-08 33.7 10.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 PIK61463.1 - 0.51 9.9 8.2 0.062 12.9 3.8 1.8 2 0 0 2 2 2 0 PHD-finger MRNIP PF15749.5 PIK61463.1 - 0.8 10.5 6.7 0.17 12.6 2.3 2.1 2 0 0 2 2 2 0 MRN-interacting protein Zn_Tnp_IS1595 PF12760.7 PIK61463.1 - 9.5 6.3 12.6 5 7.2 9.5 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain WAC_Acf1_DNA_bd PF10537.9 PIK61464.1 - 7.8e-30 103.4 0.0 3.4e-29 101.3 0.0 2.2 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 PIK61464.1 - 1.2e-13 51.4 13.3 1.2e-13 51.4 13.3 6.0 5 3 0 5 5 5 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 PIK61464.1 - 1.8e-12 46.9 6.5 1.8e-12 46.9 6.5 2.2 2 0 0 2 2 2 1 PHD-finger DDT PF02791.17 PIK61464.1 - 4.7e-09 36.4 3.6 1.3e-08 35.0 3.6 1.9 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 PIK61464.1 - 1.5e-06 27.6 0.9 8.8e-06 25.1 0.0 2.7 3 0 0 3 3 3 1 WSTF, HB1, Itc1p, MBD9 motif 1 NUDIX PF00293.28 PIK61465.1 - 0.001 19.1 0.1 0.86 9.6 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain Hyd_WA PF06462.12 PIK61467.1 - 9.4e-28 95.9 0.8 9.5e-08 31.9 0.0 5.9 6 0 0 6 6 6 4 Propeller DUF1010 PF06231.11 PIK61467.1 - 0.074 13.6 0.8 0.2 12.2 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) Hyd_WA PF06462.12 PIK61468.1 - 3.2e-07 30.2 12.8 0.0038 17.2 0.7 5.0 5 0 0 5 5 5 2 Propeller WD40 PF00400.32 PIK61468.1 - 0.36 11.8 4.4 17 6.5 0.0 4.7 5 0 0 5 5 5 0 WD domain, G-beta repeat LRR_8 PF13855.6 PIK61469.1 - 9.4e-47 156.6 67.0 1.4e-11 44.0 4.4 11.0 6 4 5 11 11 11 9 Leucine rich repeat TIR PF01582.20 PIK61469.1 - 3.7e-22 79.0 0.0 6.2e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 PIK61469.1 - 6.5e-19 67.7 78.6 9.2e-05 22.7 0.2 12.3 5 3 8 14 14 14 8 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 PIK61469.1 - 1.3e-16 61.3 0.1 4.3e-16 59.6 0.1 2.0 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.6 PIK61469.1 - 1.9e-14 53.8 30.2 5.7e-06 26.3 3.0 5.8 4 2 2 6 6 6 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK61469.1 - 8e-06 25.5 24.9 0.15 11.6 1.4 5.3 2 2 3 5 5 5 4 Leucine-rich repeat DUF1863 PF08937.11 PIK61469.1 - 0.00041 20.7 1.3 0.001 19.4 0.3 2.1 2 1 0 2 2 2 1 MTH538 TIR-like domain (DUF1863) LRR_1 PF00560.33 PIK61469.1 - 1.1 10.0 47.2 1.1 10.1 0.3 12.8 12 2 0 12 12 12 0 Leucine Rich Repeat DUF3767 PF12597.8 PIK61470.1 - 2.6e-14 52.9 0.0 2.7e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) DUF4187 PF13821.6 PIK61471.1 - 1.6e-20 72.6 1.6 1.6e-20 72.6 1.6 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 PIK61471.1 - 5.7e-16 58.1 3.4 1.2e-15 57.1 3.4 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 PIK61471.1 - 1.2e-05 25.3 2.3 1.2e-05 25.3 2.3 2.8 3 0 0 3 3 3 1 G-patch domain Myc_N PF01056.18 PIK61471.1 - 0.001 19.1 4.1 0.001 19.1 4.1 1.6 2 0 0 2 2 2 1 Myc amino-terminal region Nop14 PF04147.12 PIK61471.1 - 0.0022 16.3 9.5 0.0022 16.3 9.5 1.7 2 0 0 2 2 2 1 Nop14-like family RNA_pol_Rpc4 PF05132.14 PIK61471.1 - 0.0049 17.3 3.0 0.0049 17.3 3.0 2.2 2 0 0 2 2 2 1 RNA polymerase III RPC4 DUF2052 PF09747.9 PIK61471.1 - 0.018 15.2 7.5 0.018 15.2 7.5 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 PIK61471.1 - 0.11 11.3 4.6 0.13 11.0 4.6 1.3 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein OATP PF03137.20 PIK61471.1 - 0.19 10.0 0.0 0.19 10.0 0.0 1.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DNA_pol_phi PF04931.13 PIK61471.1 - 0.24 9.5 16.7 0.34 9.0 16.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi SpoIIP PF07454.11 PIK61471.1 - 0.3 10.5 7.6 0.084 12.3 2.4 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TRAP_alpha PF03896.16 PIK61471.1 - 1.1 8.5 9.0 2.1 7.5 9.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPA43_OB PF17875.1 PIK61471.1 - 1.1 9.9 10.1 1.4 9.5 5.6 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 PIK61471.1 - 1.3 8.7 13.2 1 9.0 8.7 2.3 2 0 0 2 2 2 0 FAM176 family MCD_N PF17408.2 PIK61471.1 - 1.8 8.8 5.9 2.1 8.5 0.5 2.9 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain CobT PF06213.12 PIK61471.1 - 2.1 7.7 18.8 0.015 14.7 10.4 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Spot_14 PF07084.12 PIK61471.1 - 4.5 7.4 9.6 2.6 8.2 0.4 2.5 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 Sporozoite_P67 PF05642.11 PIK61471.1 - 7.5 4.5 10.9 12 3.9 10.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tim54 PF11711.8 PIK61471.1 - 7.6 5.2 16.6 0.38 9.5 9.2 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Sds3 PF08598.11 PIK61472.1 - 7.5e-15 55.5 13.4 9.7e-15 55.2 13.4 1.2 1 0 0 1 1 1 1 Sds3-like eIF-1a PF01176.19 PIK61472.1 - 0.0002 21.1 1.3 0.0047 16.7 0.3 2.4 2 0 0 2 2 2 1 Translation initiation factor 1A / IF-1 DUF421 PF04239.12 PIK61472.1 - 0.056 13.2 2.7 0.11 12.3 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF421) rve PF00665.26 PIK61473.1 - 6.4e-24 84.4 0.0 1.1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 PIK61473.1 - 0.00012 21.8 0.1 0.00023 21.0 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 PIK61473.1 - 0.00052 19.7 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 PIK61474.1 - 1.7e-42 145.7 0.9 5.4e-36 124.5 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Beach PF02138.18 PIK61476.1 - 3.3e-23 82.5 0.0 6.1e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 PIK61477.1 - 9.6e-15 54.7 0.7 0.00018 22.2 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61477.1 - 2.6e-05 24.4 0.1 0.23 11.8 0.0 4.4 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cofilin_ADF PF00241.20 PIK61478.1 - 3.9e-27 94.5 0.6 4.4e-27 94.3 0.6 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Sulfotransfer_2 PF03567.14 PIK61480.1 - 1.6e-10 41.3 0.2 2.1e-10 41.0 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase family DUF4277 PF14104.6 PIK61480.1 - 0.051 13.9 0.1 2 8.8 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4277) 7tm_1 PF00001.21 PIK61481.1 - 1.2e-42 146.1 12.4 1.8e-42 145.5 12.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK61481.1 - 1.2e-13 51.0 13.1 1.6e-13 50.7 13.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK61481.1 - 0.00013 21.7 16.9 0.00034 20.3 15.8 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx RhodobacterPufX PF11511.8 PIK61481.1 - 1.5 8.5 0.0 1.5 8.5 0.0 2.6 3 0 0 3 3 3 0 Intrinsic membrane protein PufX AAA PF00004.29 PIK61482.1 - 4.8e-94 311.8 0.0 9.3e-48 162.0 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK61482.1 - 3.2e-21 74.9 0.3 1.8e-10 40.5 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 PIK61482.1 - 1.1e-13 51.2 0.0 6.7e-06 25.9 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 PIK61482.1 - 7.1e-13 49.3 1.4 0.0023 18.3 0.0 5.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 PIK61482.1 - 1e-10 42.0 0.0 6.5e-05 23.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 PIK61482.1 - 5.8e-10 38.9 0.0 0.0014 17.9 0.0 2.7 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 PIK61482.1 - 2.7e-09 37.4 1.4 0.097 12.9 0.0 4.5 2 2 2 4 4 4 2 AAA domain AAA_5 PF07728.14 PIK61482.1 - 2.8e-09 37.1 0.8 0.0018 18.3 0.1 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 PIK61482.1 - 8.9e-09 35.7 0.0 0.011 15.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 PIK61482.1 - 3.9e-08 33.4 0.0 0.014 15.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 PIK61482.1 - 2.1e-07 30.6 1.6 0.016 14.6 0.1 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 PIK61482.1 - 2.8e-07 31.1 0.4 0.0054 17.3 0.0 3.5 3 2 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 PIK61482.1 - 4.7e-07 30.1 0.0 0.068 13.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 PIK61482.1 - 1.5e-06 28.1 1.0 0.066 12.9 0.0 3.1 2 1 1 3 3 3 2 IstB-like ATP binding protein NACHT PF05729.12 PIK61482.1 - 2.1e-06 27.7 0.5 0.04 13.8 0.0 3.1 3 0 0 3 3 3 2 NACHT domain TsaE PF02367.17 PIK61482.1 - 2.2e-06 27.7 0.0 0.013 15.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 PIK61482.1 - 3.7e-06 27.0 0.0 0.036 14.0 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_3 PF07726.11 PIK61482.1 - 5.3e-06 26.3 0.0 0.028 14.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 PIK61482.1 - 8.5e-06 25.2 0.2 0.014 14.7 0.0 2.8 2 0 0 2 2 2 2 Zeta toxin AAA_28 PF13521.6 PIK61482.1 - 1e-05 25.8 0.1 0.035 14.3 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 PIK61482.1 - 2.8e-05 23.8 3.0 0.41 10.2 0.1 4.2 3 1 1 4 4 4 2 AAA domain ABC_tran PF00005.27 PIK61482.1 - 4.7e-05 23.9 2.2 0.4 11.2 0.0 3.4 3 0 0 3 3 3 2 ABC transporter Sigma54_activat PF00158.26 PIK61482.1 - 5e-05 23.1 0.1 1.5 8.5 0.0 3.4 2 1 0 2 2 2 2 Sigma-54 interaction domain Vps4_C PF09336.10 PIK61482.1 - 0.00011 22.1 0.1 0.029 14.4 0.1 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase PF06745.13 PIK61482.1 - 0.00013 21.4 0.3 1.2 8.4 0.0 3.5 3 0 0 3 3 3 1 KaiC Viral_helicase1 PF01443.18 PIK61482.1 - 0.00015 21.6 1.5 0.16 11.7 0.0 3.1 4 0 0 4 4 2 2 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 PIK61482.1 - 0.00035 19.8 0.1 0.94 8.6 0.0 2.9 3 0 0 3 3 2 2 NB-ARC domain AAA_17 PF13207.6 PIK61482.1 - 0.00044 20.7 3.7 0.23 11.9 0.0 3.6 4 0 0 4 4 2 2 AAA domain Sigma54_activ_2 PF14532.6 PIK61482.1 - 0.0021 18.2 0.1 1 9.5 0.0 3.0 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_11 PF13086.6 PIK61482.1 - 0.0034 17.2 5.5 1.6 8.5 0.0 3.8 3 0 0 3 3 3 1 AAA domain Parvo_NS1 PF01057.17 PIK61482.1 - 0.0037 16.4 0.0 1.6 7.8 0.1 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 PhoH PF02562.16 PIK61482.1 - 0.009 15.5 1.6 4 6.8 0.1 2.8 3 0 0 3 3 2 1 PhoH-like protein ATPase_2 PF01637.18 PIK61482.1 - 0.0091 15.9 0.0 9.5 6.1 0.0 3.7 2 2 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK61482.1 - 0.01 15.4 0.0 5.4 6.5 0.0 3.1 3 1 0 3 3 3 0 P-loop containing dynein motor region PduV-EutP PF10662.9 PIK61482.1 - 0.011 15.4 0.0 4.5 7.0 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin2 PF13189.6 PIK61482.1 - 0.011 15.8 0.0 3 8.0 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_24 PF13479.6 PIK61482.1 - 0.012 15.4 0.0 3.5 7.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 PIK61482.1 - 0.015 14.7 0.5 7.2 6.0 0.0 3.7 4 0 0 4 4 3 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 PIK61482.1 - 0.019 14.8 0.0 7 6.5 0.0 2.9 2 0 0 2 2 2 0 NTPase SKI PF01202.22 PIK61482.1 - 0.026 14.7 2.0 4.3 7.4 0.0 3.3 4 0 0 4 4 2 0 Shikimate kinase DUF2075 PF09848.9 PIK61482.1 - 0.027 13.7 0.1 8.8 5.4 0.1 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2075) CPT PF07931.12 PIK61482.1 - 0.042 13.7 0.0 3 7.7 0.0 2.8 3 0 0 3 3 2 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.6 PIK61482.1 - 0.064 13.0 0.5 33 4.1 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 PIK61482.1 - 0.072 13.4 2.0 11 6.4 0.1 2.8 2 1 0 2 2 2 0 AAA domain EF1G PF00647.19 PIK61483.1 - 1.5e-36 124.7 3.5 1.5e-36 124.7 3.5 1.9 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 PIK61483.1 - 6.9e-17 61.6 0.0 1.9e-16 60.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 PIK61483.1 - 8.7e-15 54.7 0.1 2.3e-14 53.4 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 PIK61483.1 - 3.6e-08 33.7 0.0 8.8e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 PIK61483.1 - 1.5e-07 31.3 0.0 3.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK61483.1 - 1.1e-06 28.7 0.1 2.8e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 PIK61483.1 - 0.00011 22.5 0.0 0.00025 21.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KMP11 PF03037.16 PIK61485.1 - 0.041 14.7 0.2 0.27 12.1 0.1 2.4 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Keratin_B2_2 PF13885.6 PIK61486.1 - 1.2e-12 47.5 32.7 2.4e-06 27.4 12.8 2.1 1 1 1 2 2 2 2 Keratin, high sulfur B2 protein Keratin_B2 PF01500.17 PIK61486.1 - 5.6e-07 29.7 43.9 0.00023 21.2 18.8 2.0 1 1 1 2 2 2 2 Keratin, high sulfur B2 protein zf-CCCH_2 PF14608.6 PIK61486.1 - 0.019 15.5 49.1 4.4 7.9 3.5 8.2 1 1 5 7 7 7 0 RNA-binding, Nab2-type zinc finger DUF2807 PF10988.8 PIK61487.1 - 0.0011 18.9 12.9 0.15 11.8 0.1 5.1 4 3 1 5 5 5 2 Putative auto-transporter adhesin, head GIN domain TamB PF04357.13 PIK61487.1 - 0.005 16.1 10.4 0.27 10.4 0.1 4.1 2 2 0 3 3 3 2 TamB, inner membrane protein subunit of TAM complex IMUP PF15761.5 PIK61487.1 - 0.029 15.1 17.5 0.029 15.1 17.5 3.8 3 1 1 4 4 4 0 Immortalisation up-regulated protein MRI PF15325.6 PIK61487.1 - 0.39 11.8 2.8 0.41 11.7 0.8 2.0 2 0 0 2 2 2 0 Modulator of retrovirus infection DUF4603 PF15376.6 PIK61487.1 - 0.57 7.5 2.6 0.81 7.0 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Macoilin PF09726.9 PIK61487.1 - 0.7 8.4 1.3 1 7.8 1.3 1.2 1 0 0 1 1 1 0 Macoilin family DUF755 PF05501.11 PIK61487.1 - 0.99 9.7 13.8 2.1 8.6 13.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SR-25 PF10500.9 PIK61487.1 - 4.2 6.9 17.7 0.035 13.7 9.3 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 PIK61487.1 - 9.1 4.2 10.0 13 3.7 10.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein 3HCDH_N PF02737.18 PIK61490.1 - 1.8e-18 67.1 0.1 4.9e-18 65.7 0.1 1.6 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain VPS9 PF02204.18 PIK61491.1 - 1.4e-23 83.1 0.0 4.6e-23 81.4 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ALIX_LYPXL_bnd PF13949.6 PIK61491.1 - 0.0023 17.3 0.5 0.0042 16.4 0.5 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV CNOT11 PF10155.9 PIK61491.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 SH2 PF00017.24 PIK61492.1 - 4.1e-13 49.2 0.0 5.7e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 PIK61492.1 - 0.084 12.3 0.0 0.46 9.9 0.0 1.9 1 1 0 1 1 1 0 SH2 domain DUF3824 PF12868.7 PIK61492.1 - 0.22 12.2 0.1 0.3 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Pkinase PF00069.25 PIK61493.1 - 2.8e-13 49.8 0.0 4.8e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61493.1 - 9.8e-08 31.6 0.0 2.1e-07 30.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT PF02985.22 PIK61493.1 - 1.1e-07 31.4 0.1 0.04 14.2 0.0 4.5 4 1 1 5 5 5 2 HEAT repeat Kinase-like PF14531.6 PIK61493.1 - 0.077 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Cnd1 PF12717.7 PIK61493.1 - 0.092 12.8 0.2 2.3 8.2 0.1 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 PIK61493.1 - 0.13 11.8 0.1 0.61 9.6 0.1 1.9 1 1 1 2 2 2 0 CLASP N terminal Cnn_1N PF07989.11 PIK61494.1 - 0.0087 16.2 0.9 0.017 15.3 0.6 1.6 1 1 1 2 2 2 1 Centrosomin N-terminal motif 1 Arm-DNA-bind_5 PF17293.2 PIK61494.1 - 0.053 14.0 0.4 0.085 13.3 0.4 1.5 1 1 0 1 1 1 0 Arm DNA-binding domain PAP2 PF01569.21 PIK61495.1 - 1.1e-14 54.4 2.0 1.1e-14 54.4 2.0 2.4 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 PIK61495.1 - 2.3e-05 24.2 10.1 2.3e-05 24.2 10.1 2.2 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 PIK61495.1 - 0.027 15.0 3.8 0.027 15.0 3.8 3.2 4 0 0 4 4 4 0 PAP2 superfamily C-terminal DUF4536 PF15055.6 PIK61496.1 - 0.0049 17.1 1.7 0.0072 16.5 1.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4536) DEAD PF00270.29 PIK61497.1 - 2.5e-37 128.4 0.1 1e-36 126.4 0.0 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK61497.1 - 2.3e-32 111.6 0.0 4.7e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 PIK61497.1 - 0.0074 16.6 0.1 0.23 11.8 0.1 2.4 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 PIK61497.1 - 0.028 13.8 0.0 0.37 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_22 PF13401.6 PIK61497.1 - 0.045 14.0 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fanconi_A PF03511.14 PIK61497.1 - 0.069 13.1 0.4 0.82 9.6 0.1 2.3 2 0 0 2 2 2 0 Fanconi anaemia group A protein AAA_30 PF13604.6 PIK61497.1 - 0.13 11.9 0.0 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain tRNA-synt_1b PF00579.25 PIK61497.1 - 0.14 11.5 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Radial_spoke PF04712.12 PIK61498.1 - 5.7e-198 658.8 13.1 7.1e-198 658.5 13.1 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein CPSF100_C PF13299.6 PIK61498.1 - 0.24 11.6 0.1 0.24 11.6 0.1 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 PIK61498.1 - 2.3 7.5 10.7 7.8 5.7 10.7 1.9 1 1 0 1 1 1 0 BUD22 MRNIP PF15749.5 PIK61498.1 - 2.9 8.6 5.2 1 10.1 0.4 2.6 3 0 0 3 3 3 0 MRN-interacting protein HsdM_N PF12161.8 PIK61498.1 - 6.7 7.3 7.0 27 5.4 0.1 3.4 3 1 0 3 3 3 0 HsdM N-terminal domain UNC-93 PF05978.16 PIK61499.1 - 1.5e-15 57.3 15.6 1.5e-15 57.3 15.6 3.2 2 2 0 2 2 2 2 Ion channel regulatory protein UNC-93 HisKA_4TM PF16926.5 PIK61499.1 - 5.7 6.5 6.2 4.8 6.7 0.1 2.6 2 1 1 3 3 3 0 Archaeal 4TM region of histidine kinase Transposase_21 PF02992.14 PIK61500.1 - 1.2e-10 41.0 0.1 1.8e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Transposase family tnp2 BEN PF10523.9 PIK61501.1 - 0.0014 18.9 0.0 0.0037 17.4 0.0 1.7 1 0 0 1 1 1 1 BEN domain Cys_Met_Meta_PP PF01053.20 PIK61502.1 - 2.4e-126 421.3 0.0 3.1e-126 421.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 PIK61502.1 - 8.9e-09 35.0 0.0 1.4e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 PIK61502.1 - 3.4e-05 23.0 0.0 7.9e-05 21.8 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V RBFA PF02033.18 PIK61503.1 - 5.5e-16 58.9 0.2 8.3e-16 58.4 0.2 1.3 1 0 0 1 1 1 1 Ribosome-binding factor A zf-C2H2 PF00096.26 PIK61504.1 - 2.7e-26 90.5 27.7 6.8e-06 26.3 0.7 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK61504.1 - 2e-20 71.7 28.4 0.00039 21.0 2.0 6.3 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK61504.1 - 8.9e-19 67.0 25.0 1.6e-06 28.3 0.3 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 PIK61504.1 - 1.9e-11 43.7 33.2 0.00061 19.7 2.7 5.8 5 1 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 PIK61504.1 - 4.2e-09 36.5 30.5 0.0008 19.7 0.7 6.1 7 0 0 7 7 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK61504.1 - 1.9e-08 34.4 25.6 0.013 15.8 0.2 5.9 6 1 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 PIK61504.1 - 1.6e-06 27.7 19.5 0.014 15.1 0.6 5.5 4 1 1 5 5 5 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 PIK61504.1 - 0.00032 20.7 13.7 0.11 12.6 1.6 4.0 3 2 0 3 3 3 2 Zinc ribbon domain zf_UBZ PF18439.1 PIK61504.1 - 0.00058 19.4 9.7 1.3 8.7 0.1 5.4 5 0 0 5 5 5 1 Ubiquitin-Binding Zinc Finger HypA PF01155.19 PIK61504.1 - 0.0038 17.2 13.3 0.16 12.0 0.9 3.4 1 1 2 3 3 3 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-BED PF02892.15 PIK61504.1 - 0.011 15.7 26.7 0.05 13.6 0.7 6.0 2 1 3 5 5 5 0 BED zinc finger XPA_N PF01286.18 PIK61504.1 - 0.031 14.3 20.4 12 6.0 0.1 6.0 6 0 0 6 6 6 0 XPA protein N-terminal zf-C2H2_2 PF12756.7 PIK61504.1 - 0.12 12.8 25.7 0.48 10.8 0.2 4.7 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 PIK61504.1 - 0.13 12.6 19.9 1.5 9.2 3.3 3.8 2 1 1 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding DUF2256 PF10013.9 PIK61504.1 - 0.13 12.4 10.6 14 5.9 0.0 4.8 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) TAXi_N PF14543.6 PIK61504.1 - 0.23 11.7 0.2 0.23 11.7 0.2 3.5 1 1 2 4 4 3 0 Xylanase inhibitor N-terminal zf-C2HE PF16278.5 PIK61504.1 - 0.35 11.4 19.8 1.4 9.5 0.4 5.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger C1_4 PF07975.12 PIK61504.1 - 0.43 10.8 19.9 0.21 11.8 2.0 4.1 3 1 1 4 4 4 0 TFIIH C1-like domain zf_C2H2_13 PF18508.1 PIK61504.1 - 1.5 8.5 8.7 4.9 6.8 0.1 4.4 4 0 0 4 4 4 0 Zinc finger domain zinc_ribbon_15 PF17032.5 PIK61504.1 - 1.9 9.3 22.4 0.17 12.6 2.9 3.5 2 1 0 3 3 3 0 zinc-ribbon family zf-ribbon_3 PF13248.6 PIK61504.1 - 2.9 7.4 8.6 8.2 6.0 0.2 3.8 3 0 0 3 3 3 0 zinc-ribbon domain DUF3268 PF11672.8 PIK61504.1 - 4.8 7.5 11.3 1.3 9.4 1.8 2.4 2 0 0 2 2 2 0 zinc-finger-containing domain zf-HYPF PF07503.12 PIK61504.1 - 5.2 6.9 9.9 8.7 6.2 0.2 3.9 3 1 0 3 3 3 0 HypF finger zf-AN1 PF01428.16 PIK61504.1 - 6.8 6.9 19.9 21 5.4 0.3 5.7 5 1 0 5 5 5 0 AN1-like Zinc finger Zn_ribbon_SprT PF17283.2 PIK61504.1 - 8 6.5 17.2 13 5.8 0.5 3.7 2 1 1 3 3 3 0 SprT-like zinc ribbon domain Pkinase PF00069.25 PIK61505.1 - 2.1e-08 33.9 0.1 1.6e-07 31.0 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61505.1 - 0.003 16.9 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK61505.1 - 0.017 14.5 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LBP_BPI_CETP_C PF02886.17 PIK61506.1 - 1.2e-41 142.7 0.0 2.1e-41 141.9 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK61506.1 - 6.1e-14 51.9 0.2 5e-13 49.0 0.2 2.2 1 1 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP PF01273.25 PIK61507.1 - 4.6e-10 39.4 0.0 1.3e-09 37.9 0.0 1.8 2 1 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 PIK61507.1 - 1.7e-06 27.7 0.0 0.0096 15.4 0.0 2.5 2 0 0 2 2 2 2 LBP / BPI / CETP family, C-terminal domain JHBP PF06585.11 PIK61507.1 - 0.001 18.3 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 Haemolymph juvenile hormone binding protein (JHBP) Nucleolin_bd PF16725.5 PIK61507.1 - 0.0034 17.0 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 Nucleolin binding domain LBP_BPI_CETP_C PF02886.17 PIK61508.1 - 3e-31 108.7 0.3 4.5e-31 108.1 0.3 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 PIK61508.1 - 6.6e-08 32.3 0.0 1.7e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain HA2 PF04408.23 PIK61509.1 - 1.2e-21 77.0 0.5 3.3e-21 75.6 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK61509.1 - 9.4e-17 61.2 0.0 2.1e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK61509.1 - 1.9e-10 41.0 0.0 4.2e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK61510.1 - 6.2e-08 32.6 0.1 1.2e-07 31.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK61510.1 - 2.1e-05 24.8 0.2 5.4e-05 23.5 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK61510.1 - 0.00015 22.1 0.0 0.00029 21.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK61510.1 - 0.00051 19.8 0.0 0.00083 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 PIK61510.1 - 0.00075 19.5 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain DUF2075 PF09848.9 PIK61510.1 - 0.0016 17.8 1.1 0.0021 17.4 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 PIK61510.1 - 0.0022 17.1 0.0 0.0039 16.3 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 PIK61510.1 - 0.0025 17.5 0.2 0.0067 16.1 0.2 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 PIK61510.1 - 0.006 16.8 0.0 0.016 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK61510.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Microtub_bd PF16796.5 PIK61510.1 - 0.014 15.4 0.2 0.026 14.5 0.2 1.4 1 0 0 1 1 1 0 Microtubule binding ABC_tran PF00005.27 PIK61510.1 - 0.017 15.6 0.4 0.1 13.1 0.0 2.2 2 0 0 2 2 2 0 ABC transporter PhoH PF02562.16 PIK61510.1 - 0.019 14.5 0.1 0.063 12.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 PIK61510.1 - 0.024 14.7 3.0 3.5 7.6 0.7 2.7 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit ATPase PF06745.13 PIK61510.1 - 0.035 13.5 0.0 0.077 12.3 0.0 1.5 1 0 0 1 1 1 0 KaiC Sigma54_activ_2 PF14532.6 PIK61510.1 - 0.038 14.1 0.0 0.097 12.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Roc PF08477.13 PIK61510.1 - 0.067 13.4 0.2 0.41 10.9 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 PIK61510.1 - 0.068 13.5 0.1 0.13 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 PIK61510.1 - 0.08 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_23 PF13476.6 PIK61510.1 - 0.084 13.4 0.3 0.084 13.4 0.3 2.3 1 1 1 2 2 1 0 AAA domain cobW PF02492.19 PIK61510.1 - 0.086 12.4 1.3 0.16 11.5 0.0 2.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 PIK61510.1 - 0.13 12.2 0.1 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 PIK61510.1 - 0.16 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 PIK61510.1 - 0.38 10.8 3.3 0.34 10.9 0.2 2.3 2 1 0 2 2 1 0 AAA domain AAA_11 PF13086.6 PIK61510.1 - 1.1 9.0 4.7 16 5.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain RhoGEF PF00621.20 PIK61512.1 - 2.5e-10 40.9 0.1 5.1e-10 39.9 0.0 1.5 2 0 0 2 2 2 1 RhoGEF domain Histone PF00125.24 PIK61512.1 - 9.6e-06 26.0 0.0 1.5e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RNase_H2_suC PF08615.11 PIK61513.1 - 4.4e-18 65.8 0.1 9.6e-16 58.2 0.1 2.2 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Rrp15p PF07890.12 PIK61514.1 - 3.1e-24 85.8 9.4 3.1e-24 85.8 9.4 2.7 3 0 0 3 3 3 1 Rrp15p TGF_beta PF00019.20 PIK61515.1 - 6.2e-20 72.1 1.2 1.4e-19 71.0 1.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 PIK61515.1 - 5.9e-17 62.2 0.0 7.7e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide DUF4905 PF16248.5 PIK61515.1 - 0.094 12.6 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4905) Jnk-SapK_ap_N PF09744.9 PIK61516.1 - 1.6 8.9 55.8 11 6.2 0.2 8.8 1 1 9 10 10 10 0 JNK_SAPK-associated protein-1 zf-C2H2_assoc3 PF16637.5 PIK61518.1 - 0.033 14.4 1.9 0.076 13.2 1.9 1.6 1 0 0 1 1 1 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz TTL PF03133.15 PIK61519.1 - 1.2e-89 300.4 0.5 2.3e-89 299.4 0.0 1.7 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK61519.1 - 1.3e-06 27.8 0.0 0.0017 17.7 0.0 2.6 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK61519.1 - 0.00077 18.8 0.0 0.27 10.4 0.0 2.5 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Pre-PUA PF17832.1 PIK61519.1 - 0.42 11.3 0.1 0.42 11.3 0.1 2.2 2 0 0 2 2 2 0 Pre-PUA-like domain AMPK1_CBM PF16561.5 PIK61520.1 - 4e-31 107.1 3.4 4e-31 107.1 3.4 1.6 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 PIK61520.1 - 2e-25 88.8 0.9 4.6e-25 87.7 0.9 1.6 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 PIK61520.1 - 4.6e-05 23.7 0.2 0.00015 22.0 0.1 1.9 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Redoxin PF08534.10 PIK61521.1 - 1.1e-34 119.2 0.1 1.4e-34 119.0 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 PIK61521.1 - 2.7e-12 46.7 0.0 3.3e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF573 PF04504.14 PIK61522.1 - 0.18 12.5 2.3 1.5 9.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF573 HEAT PF02985.22 PIK61523.1 - 4.3e-07 29.6 22.7 0.0071 16.5 0.2 8.9 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 PIK61523.1 - 6.4e-07 29.7 2.8 0.032 14.6 0.0 5.1 4 2 1 5 5 5 3 HEAT repeats Ac110_PIF PF07280.11 PIK61523.1 - 0.12 12.2 0.1 0.32 10.8 0.1 1.7 1 0 0 1 1 1 0 Per os infectivity factor AC110 HEAT_EZ PF13513.6 PIK61523.1 - 2.8 8.6 8.7 1.1 9.9 0.1 4.5 5 1 1 6 6 6 0 HEAT-like repeat zf-H2C2_2 PF13465.6 PIK61524.1 - 4.5e-12 45.8 34.2 0.00018 21.8 0.2 6.0 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK61524.1 - 1.1e-10 41.5 16.7 0.014 15.7 0.2 4.5 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK61524.1 - 9e-10 38.6 22.4 0.0025 18.1 0.4 4.6 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK61524.1 - 2.7e-06 27.5 56.8 0.0031 17.9 2.5 6.2 6 1 0 6 6 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK61524.1 - 1.3e-05 25.6 47.2 0.0026 18.4 1.2 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK61524.1 - 0.00063 20.0 17.8 0.22 11.9 13.7 4.5 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 PIK61524.1 - 0.0016 18.1 1.5 0.0016 18.1 1.5 2.9 3 0 0 3 3 3 1 zinc-finger C2H2-type Ta0938 PF11494.8 PIK61524.1 - 0.09 13.1 0.1 0.25 11.7 0.1 1.7 1 0 0 1 1 1 0 Ta0938 zf-Sec23_Sec24 PF04810.15 PIK61524.1 - 0.19 11.8 6.4 2.4 8.3 0.3 2.6 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-LYAR PF08790.11 PIK61524.1 - 0.49 10.3 10.5 0.58 10.1 0.1 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger FKBP_N PF01346.18 PIK61524.1 - 1.2 10.1 5.8 2.3 9.2 2.3 2.6 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase FEZ PF07763.13 PIK61525.1 - 2.8e-14 53.5 0.5 3.6e-14 53.1 0.5 1.1 1 0 0 1 1 1 1 FEZ-like protein Lipoxygenase PF00305.19 PIK61528.1 - 2.5e-48 165.1 0.0 4.4e-33 114.7 0.1 2.4 1 1 1 2 2 2 2 Lipoxygenase PLAT PF01477.23 PIK61528.1 - 2.7e-20 73.1 0.2 5.8e-20 72.0 0.2 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain CCDC32 PF14989.6 PIK61528.1 - 0.024 14.7 0.5 0.15 12.0 0.0 2.4 2 1 1 3 3 3 0 Coiled-coil domain containing 32 Requiem_N PF14051.6 PIK61529.1 - 1.5e-29 102.0 0.6 1.5e-29 102.0 0.6 1.9 2 0 0 2 2 2 1 N-terminal domain of DPF2/REQ. PHD PF00628.29 PIK61529.1 - 8.5e-19 67.2 17.9 2.1e-09 37.1 0.7 3.3 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 PIK61529.1 - 0.00015 21.8 4.7 0.00015 21.8 4.7 3.2 2 1 1 3 3 3 1 PHD-finger Lar_restr_allev PF14354.6 PIK61529.1 - 0.0029 18.0 1.1 0.0029 18.0 1.1 4.1 2 2 1 3 3 3 1 Restriction alleviation protein Lar zf-C2H2_4 PF13894.6 PIK61529.1 - 0.0063 17.3 4.8 0.0063 17.3 4.8 4.1 5 0 0 5 5 5 1 C2H2-type zinc finger C1_1 PF00130.22 PIK61529.1 - 0.0097 15.8 15.7 0.48 10.3 0.5 3.7 2 1 2 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 PIK61529.1 - 0.015 15.4 14.4 7.8 6.7 0.1 3.8 2 1 1 3 3 3 0 KIAA1045 RING finger zf-PHD-like PF15446.6 PIK61529.1 - 0.031 13.9 12.9 0.28 10.8 2.2 3.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-BED PF02892.15 PIK61529.1 - 0.072 13.1 0.9 0.072 13.1 0.9 2.8 3 0 0 3 3 3 0 BED zinc finger ABC_membrane PF00664.23 PIK61530.1 - 2.4e-59 201.3 12.5 3.1e-59 200.9 12.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK61530.1 - 1.6e-25 90.2 0.0 6.2e-25 88.3 0.0 2.1 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 PIK61530.1 - 1.6e-06 27.7 0.7 0.0038 16.7 0.2 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 PIK61530.1 - 1e-05 24.9 0.0 2.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 PIK61530.1 - 0.00023 21.6 0.0 0.00065 20.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK61530.1 - 0.00071 19.9 0.0 0.0038 17.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 PIK61530.1 - 0.0013 18.4 0.1 0.0036 17.0 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Yip1 PF04893.17 PIK61530.1 - 0.0037 17.0 3.0 0.0037 17.0 3.0 1.7 2 0 0 2 2 2 1 Yip1 domain ABC_membrane_3 PF13748.6 PIK61530.1 - 0.01 15.1 2.1 0.027 13.7 2.1 1.7 1 1 0 1 1 1 0 ABC transporter transmembrane region AAA_25 PF13481.6 PIK61530.1 - 0.01 15.4 0.7 0.086 12.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 PIK61530.1 - 0.02 15.0 1.3 0.033 14.3 0.1 2.0 3 0 0 3 3 3 0 Helicase HerA, central domain APS_kinase PF01583.20 PIK61530.1 - 0.041 13.8 0.0 0.093 12.6 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_21 PF13304.6 PIK61530.1 - 0.053 13.3 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 PIK61530.1 - 0.059 13.9 0.0 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 PIK61530.1 - 0.068 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK61530.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 PIK61530.1 - 0.17 11.6 0.1 0.48 10.1 0.0 1.9 2 1 0 2 2 2 0 AAA domain rve PF00665.26 PIK61531.1 - 3.3e-19 69.2 0.0 6.4e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK61531.1 - 2e-17 63.0 0.4 4.5e-17 61.9 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_3 PF13358.6 PIK61531.1 - 0.002 17.9 0.0 0.0053 16.5 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-H2C2 PF09337.10 PIK61531.1 - 0.0022 18.2 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 PIK61531.1 - 0.058 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 DDE domain rve_3 PF13683.6 PIK61531.1 - 0.06 13.1 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain RecG_N PF17190.4 PIK61534.1 - 0.032 14.9 0.2 0.066 13.9 0.2 1.9 1 1 0 1 1 1 0 RecG N-terminal helical domain Ureide_permease PF07168.11 PIK61534.1 - 0.17 10.6 0.2 0.17 10.6 0.2 1.0 1 0 0 1 1 1 0 Ureide permease Astro_capsid_N PF03115.14 PIK61534.1 - 0.35 9.5 5.8 0.4 9.3 5.8 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor LRS4 PF10422.9 PIK61534.1 - 0.42 10.1 6.8 0.56 9.7 6.8 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 ISK_Channel PF02060.15 PIK61535.1 - 0.0033 17.1 0.0 0.0082 15.9 0.0 1.6 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Synaptobrevin PF00957.21 PIK61535.1 - 0.37 10.6 0.1 0.37 10.6 0.1 1.8 3 0 0 3 3 3 0 Synaptobrevin Metallophos PF00149.28 PIK61536.1 - 2.1e-11 44.7 0.1 2.7e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK61536.1 - 0.0001 22.6 0.0 0.00034 20.8 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_31 PF01055.26 PIK61537.1 - 2.9e-66 224.5 5.6 1.2e-45 156.6 2.3 3.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK61537.1 - 1.8e-30 105.5 0.2 3.9e-30 104.4 0.2 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 PIK61537.1 - 3.7e-08 33.6 0.6 2e-07 31.2 0.2 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 PIK61537.1 - 6.8e-05 23.1 0.0 0.00019 21.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Trefoil PF00088.18 PIK61537.1 - 0.0012 18.6 0.2 0.003 17.4 0.2 1.6 1 0 0 1 1 1 1 Trefoil (P-type) domain GP17 PF17420.2 PIK61537.1 - 0.75 10.0 2.9 0.52 10.5 0.2 2.0 2 0 0 2 2 2 0 Superinfection exclusion gene product 17 SR-25 PF10500.9 PIK61538.1 - 0.037 13.6 85.9 13 5.4 85.9 2.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SSP160 PF06933.11 PIK61538.1 - 0.31 9.2 14.0 0.36 9.0 14.0 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Raftlin PF15250.6 PIK61538.1 - 4.1 6.1 18.7 5 5.8 18.7 1.0 1 0 0 1 1 1 0 Raftlin FAM199X PF15814.5 PIK61538.1 - 5.4 6.0 30.6 6.8 5.6 30.6 1.3 1 0 0 1 1 1 0 Protein family FAM199X Menin PF05053.13 PIK61538.1 - 6.5 5.0 16.1 7.3 4.8 16.1 1.1 1 0 0 1 1 1 0 Menin MAS20 PF02064.15 PIK61539.1 - 1.2e-43 148.2 0.1 1.7e-43 147.8 0.1 1.2 1 0 0 1 1 1 1 MAS20 protein import receptor Cupin_4 PF08007.12 PIK61540.1 - 3.8e-68 230.3 0.0 6.6e-68 229.5 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 PIK61540.1 - 7.2e-07 29.2 9.2 0.00039 20.2 9.2 3.4 1 1 0 1 1 1 1 Cupin-like domain Cupin_1 PF00190.22 PIK61540.1 - 0.013 15.1 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Cupin Cupin_2 PF07883.11 PIK61540.1 - 0.015 15.0 0.0 0.25 11.1 0.0 2.5 2 0 0 2 2 2 0 Cupin domain FSIP1 PF15554.6 PIK61542.1 - 3.4e-54 184.5 12.1 3.4e-54 184.5 12.1 1.6 2 0 0 2 2 2 1 FSIP1 family Uso1_p115_C PF04871.13 PIK61542.1 - 0.019 15.3 1.3 0.019 15.3 1.3 3.3 4 1 0 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.9 PIK61542.1 - 0.86 9.8 15.0 0.023 14.9 7.0 2.4 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Tup_N PF08581.10 PIK61542.1 - 4.3 7.7 10.4 14 6.1 0.6 2.9 2 0 0 2 2 2 0 Tup N-terminal Atg14 PF10186.9 PIK61543.1 - 6.3e-34 117.5 6.4 1e-33 116.8 6.4 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 PIK61543.1 - 0.0081 15.8 14.6 0.013 15.1 14.6 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit DegT_DnrJ_EryC1 PF01041.17 PIK61543.1 - 0.083 12.2 1.8 0.12 11.7 1.8 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DDHD PF02862.17 PIK61543.1 - 0.42 10.7 5.0 0.16 12.1 2.5 1.6 2 0 0 2 2 2 0 DDHD domain GAS PF13851.6 PIK61543.1 - 0.79 9.0 31.5 1 8.7 16.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-Q PF13094.6 PIK61543.1 - 1.4 9.1 21.3 7.3 6.8 20.1 2.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.11 PIK61543.1 - 2 7.3 24.8 2.9 6.7 24.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TBP PF00352.21 PIK61544.1 - 1.1e-67 224.0 0.2 5.7e-33 112.7 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 PIK61544.1 - 4.2e-05 23.6 0.0 0.3 11.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) FTHFS PF01268.19 PIK61545.1 - 2e-247 821.9 0.0 2.8e-247 821.3 0.0 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 PIK61545.1 - 2.3e-63 212.3 0.3 6e-63 210.9 0.3 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 PIK61545.1 - 4.4e-28 97.9 0.6 1e-27 96.7 0.6 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Nrap_D4 PF17405.2 PIK61546.1 - 5e-47 160.0 0.0 7.8e-47 159.4 0.0 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 PIK61546.1 - 1.2e-44 152.0 0.1 1.9e-44 151.3 0.1 1.3 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 PIK61546.1 - 1.5e-32 112.6 0.9 7.9e-21 74.7 0.0 5.5 5 0 0 5 5 5 2 Nrap protein domain 6 Nrap_D3 PF17404.2 PIK61546.1 - 1.8e-30 106.1 0.0 6.7e-30 104.3 0.0 1.9 2 0 0 2 2 2 1 Nrap protein domain 3 PA14 PF07691.12 PIK61546.1 - 0.059 13.2 7.9 39 4.0 0.0 5.0 1 1 4 5 5 5 0 PA14 domain Nrap_D2 PF17403.2 PIK61547.1 - 8.3e-36 123.0 0.4 1.3e-35 122.5 0.4 1.3 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 PIK61547.1 - 1.5e-32 112.8 0.1 2.8e-32 111.9 0.1 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 START PF01852.19 PIK61548.1 - 0.012 15.0 0.0 0.015 14.7 0.0 1.0 1 0 0 1 1 1 0 START domain DTW PF03942.15 PIK61549.1 - 1.4e-38 132.6 0.0 1.7e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 DTW domain RGM_C PF06534.13 PIK61550.1 - 5e-53 179.1 0.0 7.6e-53 178.5 0.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.12 PIK61550.1 - 4.5e-44 150.6 2.6 6.2e-44 150.1 2.6 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus VWD PF00094.25 PIK61550.1 - 0.032 14.5 0.0 0.064 13.5 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type D domain Cation_efflux PF01545.21 PIK61551.1 - 4.8e-37 127.6 8.9 4.8e-37 127.6 8.9 3.8 4 1 0 4 4 4 2 Cation efflux family Phage_holin_2_3 PF16080.5 PIK61551.1 - 0.65 9.8 5.8 3 7.7 1.0 3.3 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Serpin PF00079.20 PIK61552.1 - 9.1e-68 229.2 0.1 1e-67 229.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) A2M PF00207.22 PIK61553.1 - 1e-21 76.6 0.3 4.3e-21 74.6 0.1 2.2 2 1 1 3 3 3 1 Alpha-2-macroglobulin family TED_complement PF07678.14 PIK61553.1 - 2.5e-13 49.7 0.0 3.5e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK61554.1 - 1.5e-19 70.8 0.0 3.4e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain MG4 PF17789.1 PIK61554.1 - 4.6e-08 33.1 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Macroglobulin domain MG4 THAP PF05485.12 PIK61555.1 - 7.5e-12 46.0 0.1 3.4e-11 43.9 0.1 2.2 1 0 0 1 1 1 1 THAP domain 7tm_1 PF00001.21 PIK61556.1 - 9.2e-21 74.3 5.2 9.2e-21 74.3 5.2 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) LSDAT_euk PF18139.1 PIK61557.1 - 9.4e-89 297.3 0.0 1.2e-88 297.0 0.0 1.0 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 PIK61557.1 - 9.2e-27 93.6 0.0 8.2e-26 90.5 0.0 1.9 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote LDcluster4 PF18306.1 PIK61557.1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 SLOG cluster4 family Ion_trans PF00520.31 PIK61558.1 - 2.7e-16 59.6 19.2 4.4e-16 58.9 19.2 1.3 1 0 0 1 1 1 1 Ion transport protein ARID PF01388.21 PIK61559.1 - 2e-21 76.4 0.0 2.6e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-primase PF09329.11 PIK61560.1 - 0.47 10.3 3.2 0.26 11.1 0.2 2.1 2 0 0 2 2 2 0 Primase zinc finger LRR_8 PF13855.6 PIK61561.1 - 1.1e-36 124.4 23.0 2.7e-09 36.7 0.0 7.6 3 2 5 8 8 8 7 Leucine rich repeat LRR_5 PF13306.6 PIK61561.1 - 1e-25 90.1 0.3 2.3e-09 37.3 0.3 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK61561.1 - 4.6e-09 36.4 22.3 0.00054 20.3 0.1 7.1 4 2 5 10 10 10 6 Leucine Rich repeats (2 copies) Ephrin_rec_like PF07699.13 PIK61561.1 - 0.0045 16.7 3.0 0.0045 16.7 3.0 4.7 2 1 2 4 4 4 2 Putative ephrin-receptor like LRR_6 PF13516.6 PIK61561.1 - 0.016 15.2 12.8 4.8 7.5 0.0 7.0 9 0 0 9 9 9 0 Leucine Rich repeat LRR_1 PF00560.33 PIK61561.1 - 0.029 14.9 9.7 69 4.6 0.1 8.0 7 1 0 7 7 7 0 Leucine Rich Repeat NCD3G PF07562.14 PIK61561.1 - 0.039 13.9 0.3 0.039 13.9 0.3 4.2 3 1 1 4 4 4 0 Nine Cysteines Domain of family 3 GPCR TRP PF06011.12 PIK61561.1 - 0.04 12.6 16.5 0.074 11.8 16.5 1.3 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3302 PF11742.8 PIK61561.1 - 0.087 13.0 1.4 0.27 11.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) Sushi PF00084.20 PIK61562.1 - 3.2e-34 117.3 40.2 7.2e-07 29.7 1.2 9.2 9 0 0 9 9 9 6 Sushi repeat (SCR repeat) 7tm_2 PF00002.24 PIK61562.1 - 1.1e-23 83.8 12.8 1.7e-23 83.2 12.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK61562.1 - 1.5e-12 47.8 2.1 6.1e-12 45.9 2.1 2.2 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK61562.1 - 0.00011 21.4 9.7 0.00018 20.8 9.7 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor DUF2231 PF09990.9 PIK61562.1 - 0.096 13.1 2.5 0.21 12.0 2.5 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) Insulin_TMD PF17870.1 PIK61562.1 - 0.16 12.1 0.2 0.38 10.8 0.2 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment SLATT_5 PF18160.1 PIK61562.1 - 0.16 11.2 1.5 0.48 9.7 1.5 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Ig_3 PF13927.6 PIK61562.1 - 0.32 11.6 7.0 0.57 10.8 0.5 4.0 3 1 1 4 4 4 0 Immunoglobulin domain Sushi PF00084.20 PIK61563.1 - 1.3e-27 96.2 36.1 2.2e-06 28.2 0.3 7.2 7 0 0 7 7 7 7 Sushi repeat (SCR repeat) RVT_1 PF00078.27 PIK61564.1 - 6.9e-30 104.2 0.1 1.7e-29 102.9 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sushi PF00084.20 PIK61565.1 - 8.7e-09 35.9 13.2 9.9e-06 26.1 1.0 3.2 2 1 1 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 PIK61565.1 - 4.4 7.7 10.0 3.5 8.0 0.3 3.2 3 0 0 3 3 3 0 Hormone receptor domain Sushi PF00084.20 PIK61566.1 - 1.3e-09 38.5 13.6 9.1e-05 23.0 0.5 3.4 3 1 0 3 3 3 2 Sushi repeat (SCR repeat) cEGF PF12662.7 PIK61566.1 - 0.21 11.6 7.2 0.31 11.0 0.4 3.2 2 0 0 2 2 2 0 Complement Clr-like EGF-like Ribosomal_L28 PF00830.19 PIK61567.1 - 3.4e-06 27.1 0.1 8.9e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal L28 family 7tm_1 PF00001.21 PIK61568.1 - 1.1e-44 152.8 20.2 1.4e-44 152.4 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK61568.1 - 3e-06 27.2 16.2 5.9e-06 26.2 9.9 2.1 1 1 1 2 2 2 2 Olfactory receptor 7TM_GPCR_Srw PF10324.9 PIK61568.1 - 2.1e-05 24.0 22.9 0.0067 15.7 17.0 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw Ank_2 PF12796.7 PIK61569.1 - 4e-52 174.7 10.8 1.6e-16 60.6 1.0 3.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK61569.1 - 1.2e-27 92.9 6.4 0.00018 21.7 0.2 7.3 6 1 1 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 PIK61569.1 - 2.3e-26 91.8 2.8 2.7e-09 37.4 0.6 5.1 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 PIK61569.1 - 1.1e-23 82.5 3.0 0.0003 21.1 0.1 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 PIK61569.1 - 8.7e-22 76.9 6.0 1.9e-09 37.6 1.1 6.1 2 1 4 6 6 6 5 Ankyrin repeats (many copies) TPR_10 PF13374.6 PIK61569.1 - 0.026 14.4 0.1 0.24 11.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61569.1 - 0.1 12.9 1.1 0.9 9.9 0.0 2.9 3 1 1 4 4 4 0 Tetratricopeptide repeat MAM PF00629.23 PIK61570.1 - 1.2e-187 616.9 0.0 9e-39 133.0 0.0 6.1 6 0 0 6 6 6 6 MAM domain, meprin/A5/mu PKD PF00801.20 PIK61570.1 - 0.057 13.3 4.2 4.1 7.3 0.1 4.3 4 0 0 4 4 4 0 PKD domain fn3 PF00041.21 PIK61572.1 - 1.4e-07 31.8 0.3 4.5e-07 30.1 0.1 2.0 2 0 0 2 2 2 1 Fibronectin type III domain K_oxygenase PF13434.6 PIK61573.1 - 0.14 11.3 0.1 0.19 10.8 0.1 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) TMEM40 PF15817.5 PIK61573.1 - 1.3 8.7 7.5 0.98 9.2 1.5 2.8 1 1 2 3 3 3 0 Transmembrane protein 40 family TMEM40 PF15817.5 PIK61574.1 - 1.6 8.5 5.1 1.2 8.9 1.5 2.5 1 1 1 2 2 2 0 Transmembrane protein 40 family fn3 PF00041.21 PIK61575.1 - 3.5e-118 386.2 16.3 5.4e-11 42.7 0.0 12.5 12 0 0 12 12 12 11 Fibronectin type III domain Blo-t-5 PF11642.8 PIK61575.1 - 3.4e-15 56.1 0.0 24 4.9 0.0 9.1 9 0 0 9 9 9 1 Mite allergen Blo t 5 Interfer-bind PF09294.10 PIK61575.1 - 6.5e-15 55.3 0.0 7.4 6.9 0.0 9.3 9 0 0 9 9 9 3 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 PIK61575.1 - 8.7e-10 39.1 34.8 7 7.3 0.2 13.9 9 9 0 9 9 9 6 Purple acid Phosphatase, N-terminal domain Ribosomal_TL5_C PF14693.6 PIK61575.1 - 1.6e-06 28.4 0.0 1.6e+02 2.8 0.0 7.7 9 0 0 9 9 9 0 Ribosomal protein TL5, C-terminal domain DUF756 PF05506.12 PIK61575.1 - 9.4e-06 26.5 0.0 72 4.4 0.0 8.1 9 0 0 9 9 9 0 Domain of unknown function (DUF756) HERV-K_REC PF15695.5 PIK61575.1 - 0.002 18.1 10.7 1.2e+02 2.9 0.0 8.1 9 0 0 9 9 9 0 Rec (regulator of expression encoded by corf) of HERV-K-113 TED_complement PF07678.14 PIK61576.1 - 2e-86 289.9 0.5 2.6e-86 289.5 0.5 1.1 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK61576.1 - 2.6e-25 89.4 0.1 4e-24 85.6 0.0 2.7 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK61576.1 - 3.5e-25 87.7 0.2 1.5e-24 85.7 0.2 2.2 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 PIK61576.1 - 3.8e-19 69.2 0.2 9.7e-19 67.9 0.2 1.8 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain Thyroglobulin_1 PF00086.18 PIK61576.1 - 1.3e-12 47.2 3.6 3.4e-12 45.8 3.6 1.7 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat EGF_CA PF07645.15 PIK61576.1 - 8.8e-07 29.0 7.5 8.8e-07 29.0 7.5 2.5 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 PIK61576.1 - 0.00011 22.4 4.1 0.00044 20.5 4.1 2.1 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site SVA PF05326.11 PIK61576.1 - 0.00032 20.7 0.0 0.00098 19.1 0.0 1.8 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) DUF5640 PF18692.1 PIK61576.1 - 0.065 13.3 1.7 0.21 11.7 1.7 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5640) ODAPH PF15848.5 PIK61576.1 - 0.15 12.5 0.7 0.37 11.3 0.7 1.6 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein Prenyltrans PF00432.21 PIK61576.1 - 0.16 11.7 0.0 18 5.2 0.0 2.8 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat cEGF PF12662.7 PIK61576.1 - 0.17 11.8 0.1 0.17 11.8 0.1 3.0 3 0 0 3 3 2 0 Complement Clr-like EGF-like hEGF PF12661.7 PIK61576.1 - 0.19 12.4 4.2 0.97 10.2 4.2 2.3 1 0 0 1 1 1 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 PIK61576.1 - 0.28 11.5 6.1 0.8 10.1 6.1 1.9 1 0 0 1 1 1 0 Pvs28 EGF domain EGF PF00008.27 PIK61576.1 - 4.6 7.6 13.1 0.054 13.8 3.9 2.6 3 0 0 3 3 3 0 EGF-like domain TED_complement PF07678.14 PIK61577.1 - 2.6e-86 289.5 0.5 4e-86 288.9 0.5 1.3 1 0 0 1 1 1 1 A-macroglobulin TED domain Thyroglobulin_1 PF00086.18 PIK61577.1 - 7.3e-50 166.5 37.9 1.3e-13 50.4 4.6 4.6 4 0 0 4 4 4 4 Thyroglobulin type-1 repeat A2M_BRD PF07703.14 PIK61577.1 - 3.4e-31 108.5 0.3 4.6e-24 85.4 0.0 4.6 4 0 0 4 4 4 3 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK61577.1 - 5.6e-25 87.0 0.2 2e-24 85.2 0.2 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG3 PF17791.1 PIK61577.1 - 5.5e-21 74.6 0.3 4.6e-20 71.7 0.4 2.5 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG2 PF01835.19 PIK61577.1 - 5.4e-15 55.6 0.0 6.3e-14 52.2 0.0 2.6 2 0 0 2 2 2 1 MG2 domain MG4 PF17789.1 PIK61577.1 - 1.1e-14 54.4 0.1 6.5e-14 51.8 0.1 2.5 1 0 0 1 1 1 1 Macroglobulin domain MG4 SVA PF05326.11 PIK61577.1 - 0.00044 20.2 0.0 0.0013 18.7 0.0 1.8 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) DUF4198 PF10670.9 PIK61577.1 - 0.012 16.0 0.0 2.6 8.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4198) ODAPH PF15848.5 PIK61577.1 - 0.047 14.1 0.3 0.16 12.4 0.3 1.9 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein bMG5 PF17972.1 PIK61577.1 - 0.07 13.5 0.2 0.4 11.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial Alpha-2-macroglobulin MG5 domain Laminin_EGF PF00053.24 PIK61577.1 - 3.2 8.0 25.8 2.8 8.1 1.5 5.0 4 0 0 4 4 4 0 Laminin EGF domain TED_complement PF07678.14 PIK61578.1 - 2e-91 306.3 0.0 2.7e-91 305.9 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 PIK61578.1 - 1e-30 107.0 0.1 9.1e-28 97.4 0.0 2.8 2 0 0 2 2 2 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 PIK61578.1 - 7.8e-26 89.8 0.1 2.9e-25 87.9 0.1 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG3 PF17791.1 PIK61578.1 - 1e-23 83.3 1.6 1.8e-18 66.6 0.0 3.6 4 0 0 4 4 4 2 Macroglobulin domain MG3 A2M_recep PF07677.14 PIK61578.1 - 1.3e-23 83.5 0.9 1.3e-23 83.5 0.9 2.4 3 0 0 3 3 3 1 A-macroglobulin receptor binding domain MG2 PF01835.19 PIK61578.1 - 3.8e-15 56.1 0.0 1.2e-14 54.5 0.0 1.9 1 0 0 1 1 1 1 MG2 domain MG4 PF17789.1 PIK61578.1 - 8.6e-08 32.2 0.0 2.8e-06 27.4 0.0 2.8 2 0 0 2 2 2 1 Macroglobulin domain MG4 SVA PF05326.11 PIK61578.1 - 0.0065 16.5 0.3 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Seminal vesicle autoantigen (SVA) Big_1 PF02369.16 PIK61578.1 - 0.068 13.2 0.0 0.79 9.8 0.0 2.9 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 1) NTR PF01759.21 PIK61578.1 - 0.11 12.3 0.0 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 UNC-6/NTR/C345C module VCBS PF13517.6 PIK61579.1 - 1.1e-40 138.1 45.7 7.4e-10 39.3 3.2 4.6 1 1 4 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK61579.1 - 9.2e-23 80.0 24.6 0.00036 20.6 0.2 6.8 6 0 0 6 6 6 6 FG-GAP repeat TcdB_toxin_midN PF12256.8 PIK61579.1 - 5.3e-14 52.0 9.3 0.095 12.1 0.0 6.0 1 1 4 6 6 6 5 Insecticide toxin TcdB middle/N-terminal region SH3_5 PF08460.10 PIK61579.1 - 2.7e-05 24.2 7.4 0.27 11.4 0.1 5.0 5 0 0 5 5 5 2 Bacterial SH3 domain DEFB136 PF17333.2 PIK61579.1 - 0.0017 18.3 7.6 43 4.2 0.0 5.9 6 0 0 6 6 6 0 Beta defensin 136 DsbG_N PF18257.1 PIK61579.1 - 0.0051 16.9 0.0 19 5.5 0.0 3.6 4 0 0 4 4 4 1 Disulfide isomerase DsbG N-terminal ABC-3 PF00950.17 PIK61579.1 - 0.015 14.9 0.0 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 ABC 3 transport family Dockerin_1 PF00404.18 PIK61579.1 - 0.33 11.2 14.5 76 3.6 0.0 5.5 6 0 0 6 6 6 0 Dockerin type I domain Defensin_4 PF07936.12 PIK61579.1 - 0.75 9.7 15.1 13 5.7 0.1 6.7 7 0 0 7 7 7 0 Potassium-channel blocking toxin Sushi PF00084.20 PIK61580.1 - 1.9e-25 89.2 27.5 1.5e-07 31.9 0.6 5.2 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) Ig_3 PF13927.6 PIK61580.1 - 0.096 13.3 3.3 0.71 10.5 0.1 3.6 4 1 0 4 4 4 0 Immunoglobulin domain Sushi PF00084.20 PIK61581.1 - 3.9e-45 152.2 40.2 1.3e-09 38.5 0.5 7.2 7 0 0 7 7 7 7 Sushi repeat (SCR repeat) Zona_pellucida PF00100.23 PIK61582.1 - 2.7e-34 119.1 9.3 2.7e-34 119.1 9.3 1.6 2 0 0 2 2 2 1 Zona pellucida-like domain Sushi PF00084.20 PIK61582.1 - 2.4e-08 34.5 6.8 9.4e-06 26.1 0.7 3.2 1 1 0 2 2 2 2 Sushi repeat (SCR repeat) Zona_pellucida PF00100.23 PIK61583.1 - 6.8e-32 111.3 5.3 1.3e-31 110.4 5.3 1.5 1 0 0 1 1 1 1 Zona pellucida-like domain Sushi PF00084.20 PIK61583.1 - 6.1e-24 84.4 24.9 2.1e-07 31.5 1.0 5.2 6 0 0 6 6 6 4 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK61584.1 - 6.3e-18 65.1 19.4 5.6e-10 39.7 1.7 4.7 4 1 0 4 4 4 3 Sushi repeat (SCR repeat) Sushi PF00084.20 PIK61585.1 - 4.8e-18 65.5 11.2 1.9e-09 38.0 0.3 3.2 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Zona_pellucida PF00100.23 PIK61586.1 - 2.2e-30 106.3 3.1 2.2e-30 106.3 3.1 2.5 2 1 0 2 2 2 1 Zona pellucida-like domain Sushi PF00084.20 PIK61586.1 - 2.2e-23 82.6 39.2 6.7e-10 39.4 0.7 5.8 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Fer4_10 PF13237.6 PIK61586.1 - 2.2 8.5 9.5 1.1 9.4 0.5 3.2 3 0 0 3 3 3 0 4Fe-4S dicluster domain RVT_1 PF00078.27 PIK61587.1 - 5.6e-31 107.8 0.0 9e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK61587.1 - 1e-28 99.3 0.0 3.3e-28 97.6 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK61587.1 - 3.8e-26 91.4 0.0 8.4e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK61587.1 - 2.1e-20 73.1 0.0 5.4e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK61587.1 - 5.2e-18 64.9 0.1 1e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 PIK61587.1 - 1.2e-05 25.1 2.0 1.2e-05 25.1 2.0 2.1 2 0 0 2 2 1 1 Zinc knuckle gag-asp_proteas PF13975.6 PIK61587.1 - 0.006 17.1 0.0 0.014 15.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 PIK61587.1 - 0.0087 15.8 0.0 0.035 13.9 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK61587.1 - 0.01 16.0 0.0 0.036 14.3 0.0 2.0 1 0 0 1 1 1 0 H2C2 zinc finger RVP PF00077.20 PIK61587.1 - 0.018 15.3 0.0 0.062 13.6 0.0 1.9 1 1 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 PIK61587.1 - 0.02 15.5 0.0 0.045 14.4 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_2 PF13696.6 PIK61587.1 - 0.076 12.9 1.4 0.23 11.3 1.4 1.9 1 0 0 1 1 1 0 Zinc knuckle SRCR PF00530.18 PIK61588.1 - 4.8e-143 466.6 37.6 5.2e-29 100.7 2.0 7.1 7 0 0 7 7 7 7 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61588.1 - 5.7e-31 106.9 27.4 1.7e-05 25.3 0.0 7.6 8 0 0 8 8 8 6 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61588.1 - 1.5e-16 60.9 0.8 0.0026 18.3 0.0 7.0 7 0 0 7 7 7 5 Hepsin, SRCR domain YecR PF13992.6 PIK61588.1 - 0.00015 21.9 5.9 8.5 6.8 0.0 6.5 8 0 0 8 8 8 2 YecR-like lipoprotein DUF2273 PF10031.9 PIK61588.1 - 7.5 6.7 6.7 15 5.7 6.7 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) SRCR PF00530.18 PIK61589.1 - 1.3e-144 471.7 15.2 2.5e-30 104.9 0.3 5.1 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61589.1 - 1e-34 119.0 13.3 6.6e-06 26.6 0.2 5.6 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61589.1 - 9.7e-19 67.9 0.3 0.094 13.2 0.0 5.8 6 0 0 6 6 6 5 Hepsin, SRCR domain PT PF04886.12 PIK61589.1 - 1.2e-05 24.7 2.1 0.0053 16.3 0.7 2.7 2 0 0 2 2 2 2 PT repeat CD20 PF04103.15 PIK61590.1 - 0.00014 21.9 14.5 0.00038 20.6 14.1 1.8 1 1 1 2 2 2 1 CD20-like family Ost5 PF05251.12 PIK61590.1 - 0.052 13.8 1.1 0.052 13.8 1.1 2.6 2 1 0 2 2 2 0 Oligosaccharyltransferase subunit 5 SHP PF03579.13 PIK61590.1 - 0.22 11.5 1.7 1.1 9.3 0.2 2.2 2 0 0 2 2 2 0 Small hydrophobic protein 7tm_1 PF00001.21 PIK61591.1 - 7e-32 110.8 2.0 7e-32 110.8 2.0 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK61591.1 - 6.1e-07 29.1 1.9 9.4e-07 28.5 1.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK61591.1 - 9.7e-07 28.7 5.6 1.5e-06 28.1 5.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 PIK61591.1 - 7.4e-06 25.5 7.0 2.8e-05 23.6 7.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 PIK61591.1 - 9.2e-06 25.6 4.3 1.7e-05 24.7 4.3 1.5 1 1 0 1 1 1 1 Olfactory receptor TMEM154 PF15102.6 PIK61591.1 - 0.17 11.8 0.6 1.1 9.1 0.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family 7TM_GPCR_Srbc PF10316.9 PIK61591.1 - 1.1 8.7 11.4 0.042 13.4 5.5 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc PNMA PF14893.6 PIK61592.1 - 0.019 14.4 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 PNMA AMP-binding PF00501.28 PIK61593.1 - 6.5e-24 84.3 0.0 7.7e-24 84.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme POTRA_2 PF08479.11 PIK61593.1 - 0.081 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 POTRA domain, ShlB-type AMP-binding PF00501.28 PIK61594.1 - 2.7e-18 65.8 0.0 3.4e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK61594.1 - 1.8e-09 38.5 0.0 2.8e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 PIK61595.1 - 7.8e-62 209.2 0.0 9.6e-62 208.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 PIK61595.1 - 1.2e-08 35.8 0.0 2.3e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_transf_10 PF00852.19 PIK61596.1 - 3.2e-46 157.3 0.5 5.8e-46 156.4 0.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK61596.1 - 1.5e-10 41.5 0.0 3.3e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Abhydrolase_9 PF10081.9 PIK61596.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Ig_3 PF13927.6 PIK61597.1 - 1.9e-10 41.2 0.2 0.029 15.0 0.0 4.1 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 PIK61597.1 - 2.4e-07 30.9 0.1 8.4e-05 22.7 0.0 3.6 2 1 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.16 PIK61597.1 - 0.0024 17.9 0.0 15 5.7 0.0 4.3 3 1 1 4 4 4 1 Immunoglobulin I-set domain ig PF00047.25 PIK61597.1 - 0.0088 16.2 0.0 2.3 8.4 0.0 3.9 3 2 0 3 3 3 1 Immunoglobulin domain DUF4711 PF15829.5 PIK61598.1 - 0.029 14.3 0.1 0.029 14.3 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4711) FA PF08736.11 PIK61598.1 - 0.039 14.0 0.7 0.039 14.0 0.7 2.1 2 0 0 2 2 2 0 FERM adjacent (FA) zf-HIT PF04438.16 PIK61598.1 - 0.057 13.3 1.7 43 4.1 0.1 3.2 3 0 0 3 3 3 0 HIT zinc finger ABC_export PF16962.5 PIK61598.1 - 0.21 10.0 0.1 0.3 9.5 0.1 1.1 1 0 0 1 1 1 0 Putative ABC exporter Ribosomal_S22 PF08136.11 PIK61598.1 - 0.84 10.0 5.1 30 5.1 0.1 4.1 4 1 1 5 5 5 0 30S ribosomal protein subunit S22 family Glyco_hydro_31 PF01055.26 PIK61599.1 - 1.9e-152 508.5 9.1 2.8e-152 507.9 9.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 PIK61599.1 - 2.4e-23 82.5 0.2 5.4e-23 81.4 0.2 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 PIK61599.1 - 4e-08 33.5 0.5 1.5e-07 31.6 0.5 2.1 1 0 0 1 1 1 1 Galactose mutarotase-like Trefoil PF00088.18 PIK61599.1 - 5.6e-06 26.1 5.5 5.6e-06 26.1 5.5 1.9 2 0 0 2 2 2 1 Trefoil (P-type) domain DUF5110 PF17137.4 PIK61599.1 - 0.005 17.1 0.0 0.022 15.0 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) NtCtMGAM_N PF16863.5 PIK61600.1 - 3.7e-18 65.8 0.0 5.4e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 PIK61600.1 - 3.5e-09 36.4 5.4 6e-09 35.6 5.4 1.4 1 0 0 1 1 1 1 Trefoil (P-type) domain PTPS PF01242.19 PIK61601.1 - 2.9e-13 49.9 0.3 3e-13 49.8 0.3 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase DUF3862 PF12978.7 PIK61601.1 - 0.054 13.3 0.4 0.21 11.4 0.4 1.8 1 1 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) Pkinase_Tyr PF07714.17 PIK61602.1 - 3e-89 298.7 0.0 3.9e-89 298.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK61602.1 - 1.3e-37 129.6 0.0 1.7e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 PIK61602.1 - 0.03 13.7 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 PIK61602.1 - 0.044 13.4 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 PIK61602.1 - 0.073 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Proteasome PF00227.26 PIK61603.1 - 9e-54 181.8 0.0 1.2e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 PIK61603.1 - 7.3e-14 51.1 0.1 1.3e-13 50.3 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SoPB_HTH PF18090.1 PIK61603.1 - 0.1 12.8 0.0 0.3 11.2 0.0 1.8 1 0 0 1 1 1 0 Centromere-binding protein HTH domain DUF1192 PF06698.11 PIK61603.1 - 0.13 12.4 3.4 0.23 11.5 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) RNA_pol_3_Rpc31 PF11705.8 PIK61604.1 - 5.5e-30 105.3 7.9 7.4e-30 104.9 7.9 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 TBPIP PF07106.13 PIK61604.1 - 0.0021 17.9 0.3 0.004 17.1 0.3 1.3 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain DUF1770 PF08589.10 PIK61604.1 - 0.39 11.7 3.3 0.98 10.4 0.5 2.4 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) LysM PF01476.20 PIK61605.1 - 0.00013 22.0 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 LysM domain PAH PF02671.21 PIK61606.1 - 2.5e-05 24.3 5.1 0.00033 20.7 2.2 2.8 2 0 0 2 2 2 1 Paired amphipathic helix repeat Med15_fungi PF05397.12 PIK61606.1 - 0.026 14.8 4.0 0.084 13.1 4.0 1.8 1 0 0 1 1 1 0 Mediator complex subunit 15 PARG_cat PF05028.14 PIK61606.1 - 0.036 13.4 0.1 0.036 13.4 0.1 2.2 2 0 0 2 2 2 0 Poly (ADP-ribose) glycohydrolase (PARG) Choline_kinase PF01633.20 PIK61606.1 - 0.047 13.3 1.1 0.11 12.0 1.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase YlqD PF11068.8 PIK61606.1 - 8.9 6.7 11.9 1.6 9.1 5.8 2.6 2 0 0 2 2 2 0 YlqD protein 7tm_1 PF00001.21 PIK61607.1 - 2.7e-36 125.3 20.1 3.5e-36 124.9 20.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 PIK61607.1 - 4.1e-08 32.9 18.6 5.4e-08 32.5 18.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv RFX_DNA_binding PF02257.15 PIK61607.1 - 0.065 13.9 0.1 0.16 12.6 0.1 1.6 1 0 0 1 1 1 0 RFX DNA-binding domain DUF373 PF04123.13 PIK61607.1 - 2.2 7.7 14.9 0.31 10.5 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DUF2207 PF09972.9 PIK61607.1 - 4.3 6.0 14.4 0.03 13.1 1.2 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF1180 PF06679.12 PIK61608.1 - 5.7e-18 65.9 0.1 7e-18 65.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) DUF4064 PF13273.6 PIK61608.1 - 0.027 14.8 0.1 0.039 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF751 PF05421.11 PIK61608.1 - 0.03 15.0 2.5 0.086 13.6 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF751) PWWP PF00855.17 PIK61609.1 - 7.9e-09 35.8 0.2 2.9e-08 34.0 0.2 2.1 1 0 0 1 1 1 1 PWWP domain UDPGT PF00201.18 PIK61610.1 - 1.7e-106 357.0 0.0 2e-106 356.8 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK61610.1 - 6.1e-11 42.6 0.0 1.9e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 PIK61610.1 - 0.03 13.6 0.1 0.21 10.8 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 1 UDPGT PF00201.18 PIK61611.1 - 2.1e-102 343.5 0.1 2.9e-102 343.1 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK61611.1 - 2.3e-05 24.4 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DUF4713 PF15831.5 PIK61611.1 - 0.46 11.0 15.3 1.8 9.0 15.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) TTL PF03133.15 PIK61613.1 - 6.8e-85 284.8 0.6 1.1e-84 284.1 0.6 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 PIK61613.1 - 1.7e-10 40.6 0.1 2.5e-06 26.9 0.0 3.1 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 PIK61613.1 - 1.4e-06 27.8 0.0 0.014 14.7 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 PIK61613.1 - 0.0017 18.4 0.0 0.023 14.7 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 PIK61613.1 - 0.046 13.3 0.0 5.5 6.5 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain fn3 PF00041.21 PIK61614.1 - 2.5e-46 155.9 13.9 2e-14 53.7 0.5 8.3 8 0 0 8 8 8 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK61614.1 - 1.8e-13 50.9 14.9 0.044 14.4 0.8 9.1 9 0 0 9 9 9 4 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 PIK61614.1 - 0.0022 18.5 1.3 1.6 9.4 0.0 5.1 5 1 1 6 6 6 1 PhoD-like phosphatase, N-terminal domain Y_Y_Y PF07495.13 PIK61614.1 - 0.7 9.9 3.3 0.97 9.4 0.3 2.9 2 0 0 2 2 2 0 Y_Y_Y domain PhoD_N PF16655.5 PIK61616.1 - 0.0028 18.1 0.2 0.096 13.2 0.1 2.9 2 1 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 PIK61616.1 - 0.01 16.4 7.0 1.1 9.9 2.0 3.9 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain UDPGT PF00201.18 PIK61617.1 - 2.5e-106 356.5 0.1 1.9e-90 304.1 0.1 2.0 1 1 1 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK61617.1 - 5.8e-11 42.7 0.0 1e-10 41.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Trypsin PF00089.26 PIK61618.1 - 1.1e-46 159.5 0.1 2.1e-46 158.5 0.0 1.5 2 0 0 2 2 2 1 Trypsin Ldl_recept_a PF00057.18 PIK61618.1 - 6.4e-13 48.7 26.0 1.8e-06 28.0 7.2 2.8 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A CUB PF00431.20 PIK61618.1 - 4.7e-08 33.3 0.1 1.5e-07 31.7 0.1 1.8 2 0 0 2 2 2 1 CUB domain DUF1986 PF09342.11 PIK61618.1 - 3.7e-05 24.1 0.0 0.0001 22.6 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) AFG1_ATPase PF03969.16 PIK61619.1 - 8.7e-55 186.1 0.2 9.2e-34 116.9 0.0 2.0 2 0 0 2 2 2 2 AFG1-like ATPase AFG1_ATPase PF03969.16 PIK61620.1 - 4.8e-28 98.1 0.1 5.5e-28 97.9 0.1 1.0 1 0 0 1 1 1 1 AFG1-like ATPase AAA_16 PF13191.6 PIK61620.1 - 0.00018 21.9 0.0 0.00036 20.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 PIK61620.1 - 0.0024 18.2 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK61620.1 - 0.012 16.0 0.0 0.023 15.1 0.0 1.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 PIK61620.1 - 0.013 15.4 0.0 0.029 14.3 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 PIK61620.1 - 0.015 14.8 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Mrx7 PF10906.8 PIK61620.1 - 0.019 15.2 0.8 0.019 15.2 0.8 1.7 2 0 0 2 2 2 0 MIOREX complex component 7 TsaE PF02367.17 PIK61620.1 - 0.049 13.6 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE WD40 PF00400.32 PIK61621.1 - 3e-31 107.0 9.7 2.9e-06 27.9 0.0 8.7 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61621.1 - 1.1e-10 41.7 1.9 0.098 13.0 0.0 6.0 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 PIK61621.1 - 1.9e-05 23.7 2.6 0.027 13.4 0.2 4.0 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 PIK61621.1 - 0.0025 17.2 0.2 0.0074 15.7 0.2 1.8 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 PIK61621.1 - 0.0045 16.0 0.7 2.4 7.0 0.0 3.8 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 PIK61621.1 - 0.02 15.0 0.3 1.5 8.9 0.1 3.8 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Hira PF07569.11 PIK61621.1 - 0.34 10.6 1.5 0.98 9.1 0.0 2.4 3 0 0 3 3 3 0 TUP1-like enhancer of split Utp12 PF04003.12 PIK61622.1 - 6.7e-21 74.6 0.1 1.1e-20 73.9 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 PIK61622.1 - 1.2e-18 67.1 8.5 2.1e-08 34.7 0.1 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61622.1 - 0.002 18.4 0.0 1.1 9.6 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 PIK61622.1 - 0.0045 16.4 0.0 0.013 14.9 0.0 1.7 2 1 0 2 2 2 1 WD40-like domain DUF753 PF05444.12 PIK61623.1 - 0.0053 16.8 6.0 0.0089 16.0 6.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF753) LRR_8 PF13855.6 PIK61623.1 - 0.028 14.2 7.4 0.86 9.4 1.7 2.4 2 0 0 2 2 2 0 Leucine rich repeat 7tm_2 PF00002.24 PIK61624.1 - 3.8e-39 134.5 20.7 7e-39 133.6 20.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK61624.1 - 1.1e-16 61.1 8.1 3.3e-16 59.5 8.1 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 PIK61624.1 - 2.1e-05 24.7 0.3 5.5e-05 23.4 0.3 1.7 1 0 0 1 1 1 1 Hormone receptor domain MCR_gamma PF02240.16 PIK61624.1 - 0.13 11.5 0.3 0.99 8.6 0.0 2.1 2 0 0 2 2 2 0 Methyl-coenzyme M reductase gamma subunit TEX29 PF15839.5 PIK61624.1 - 0.98 10.1 3.6 2.5 8.7 0.5 2.6 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein 7tm_1 PF00001.21 PIK61624.1 - 1.6 8.0 15.3 3.2 7.0 15.3 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.24 PIK61625.1 - 2.2e-15 56.5 11.2 1.6e-07 30.6 0.0 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK61625.1 - 2.5e-14 53.0 8.5 4.7e-14 52.1 8.5 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 PIK61625.1 - 0.00067 18.6 5.8 0.0008 18.4 4.7 1.7 1 1 1 2 2 2 1 MFS_1 like family Myelin_PLP PF01275.19 PIK61625.1 - 0.061 13.2 3.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Myelin proteolipid protein (PLP or lipophilin) Sugar_tr PF00083.24 PIK61626.1 - 1e-13 51.0 13.6 1.3e-13 50.6 13.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK61626.1 - 5.2e-11 42.1 16.5 7.1e-11 41.6 16.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily BIR PF00653.21 PIK61627.1 - 3.8e-27 94.7 1.7 1.4e-13 51.3 0.4 2.2 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK61627.1 - 3.2e-07 30.4 0.4 0.022 14.8 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like zf_UBZ PF18439.1 PIK61627.1 - 0.075 12.6 0.4 8.5 6.1 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF4428 PF14471.6 PIK61627.1 - 0.079 12.9 3.2 2 8.4 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) DotU PF09850.9 PIK61627.1 - 0.17 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system protein DotU BIR PF00653.21 PIK61628.1 - 7.5e-27 93.8 4.1 9.4e-13 48.6 0.4 2.6 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK61628.1 - 8.3e-08 32.3 2.4 0.0028 17.7 0.6 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Headcase PF16002.5 PIK61628.1 - 0.11 11.9 2.4 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Headcase protein RNA_pol_N PF01194.17 PIK61628.1 - 3.3 8.1 6.8 16 5.9 0.6 3.5 3 1 0 3 3 3 0 RNA polymerases N / 8 kDa subunit BIR PF00653.21 PIK61629.1 - 3.6e-46 155.7 6.7 5e-20 71.9 1.0 3.9 2 1 1 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 PIK61629.1 - 1.4e-12 47.3 9.9 1.4e-12 47.3 9.9 3.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK61629.1 - 2.9e-08 33.5 9.8 1.3e-07 31.4 9.8 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC PF07967.13 PIK61629.1 - 1.8e-06 28.0 8.2 0.0045 17.0 0.1 4.4 3 2 1 4 4 4 2 C3HC zinc finger-like zf-RING_2 PF13639.6 PIK61629.1 - 0.012 15.9 9.9 0.012 15.9 9.9 3.1 5 1 0 5 5 5 0 Ring finger domain zf-RING_5 PF14634.6 PIK61629.1 - 0.012 15.5 8.0 0.012 15.5 8.0 2.7 3 0 0 3 3 3 0 zinc-RING finger domain RNA_pol_N PF01194.17 PIK61629.1 - 0.063 13.6 2.0 9.8 6.6 0.1 3.8 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit zf-C2H2_12 PF18658.1 PIK61629.1 - 0.39 10.3 2.5 1.2 8.8 0.0 3.0 3 0 0 3 3 3 0 Zinc-finger C2H2-type DUF2039 PF10217.9 PIK61629.1 - 0.79 10.1 9.3 0.17 12.3 5.2 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 PIK61629.1 - 1.3 9.7 4.6 2.2 8.9 2.8 2.4 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT BIR PF00653.21 PIK61630.1 - 2.4e-44 149.8 7.1 1.8e-18 66.9 0.2 3.5 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK61630.1 - 9.9e-05 22.4 8.2 0.1 12.6 0.2 3.3 3 0 0 3 3 3 2 C3HC zinc finger-like RNA_pol_N PF01194.17 PIK61630.1 - 0.1 12.9 0.9 43 4.5 0.0 3.4 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit BIR PF00653.21 PIK61632.1 - 5.8e-26 91.0 0.9 1.5e-18 67.2 0.0 2.2 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 PIK61632.1 - 7.5e-06 26.0 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like MFS_1 PF07690.16 PIK61633.1 - 8.5e-12 44.7 23.8 1.1e-07 31.2 8.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Syndecan PF01034.20 PIK61634.1 - 0.02 14.8 0.3 0.034 14.1 0.3 1.3 1 0 0 1 1 1 0 Syndecan domain Rax2 PF12768.7 PIK61634.1 - 0.039 13.4 0.7 0.06 12.8 0.7 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TraL PF07178.11 PIK61634.1 - 0.23 12.0 0.2 0.39 11.2 0.2 1.3 1 0 0 1 1 1 0 TraL protein SRCR PF00530.18 PIK61635.1 - 3.6e-28 98.0 0.2 1.4e-27 96.1 0.2 1.8 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61635.1 - 4.5e-07 30.3 0.1 8.2e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61635.1 - 0.071 13.6 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Hepsin, SRCR domain SRCR PF00530.18 PIK61636.1 - 2.2e-24 85.8 0.2 2.8e-24 85.5 0.2 1.1 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61636.1 - 1.1e-06 29.1 1.4 1.1e-06 29.1 0.3 1.5 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61636.1 - 0.021 15.3 0.1 0.046 14.2 0.0 1.6 2 0 0 2 2 2 0 Hepsin, SRCR domain RVT_1 PF00078.27 PIK61637.1 - 1.4e-15 57.4 0.1 4.7e-15 55.7 0.1 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK61638.1 - 8.9e-20 71.1 0.0 1.1e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK61638.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK61638.1 - 0.02 15.1 0.0 0.029 14.6 0.0 1.2 1 0 0 1 1 1 0 DDE domain zf-CCHC PF00098.23 PIK61639.1 - 1.1e-05 25.2 1.0 1.1e-05 25.2 1.0 2.2 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 PIK61639.1 - 0.0017 18.0 0.7 0.0039 16.9 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 PIK61639.1 - 1.6 8.5 7.0 0.19 11.4 2.4 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger SRCR PF00530.18 PIK61640.1 - 2.8e-56 188.2 8.4 1.9e-24 86.0 0.5 4.1 4 0 0 4 4 4 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61640.1 - 3.8e-12 46.6 0.8 3.9e-05 24.1 0.1 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain YecR PF13992.6 PIK61640.1 - 0.0013 19.0 1.0 2.3 8.6 0.0 2.8 2 0 0 2 2 2 2 YecR-like lipoprotein Rax2 PF12768.7 PIK61640.1 - 0.0032 17.0 0.1 0.0049 16.4 0.1 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Hepsin-SRCR PF09272.10 PIK61640.1 - 0.0046 17.4 0.0 2.2 8.8 0.0 2.4 2 0 0 2 2 2 2 Hepsin, SRCR domain TraL PF07178.11 PIK61640.1 - 0.11 13.0 0.3 0.19 12.2 0.3 1.3 1 0 0 1 1 1 0 TraL protein Phage_Coat_Gp8 PF05371.12 PIK61640.1 - 0.23 11.2 0.2 0.42 10.4 0.2 1.3 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Syndecan PF01034.20 PIK61640.1 - 0.26 11.2 0.4 0.48 10.4 0.4 1.3 1 0 0 1 1 1 0 Syndecan domain TCR PF03638.15 PIK61641.1 - 1.3 9.4 16.5 2 8.8 16.5 1.3 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain preSET_CXC PF18264.1 PIK61641.1 - 1.3 9.6 17.0 4.2 7.9 16.7 1.9 1 1 1 2 2 2 0 CXC domain DUF3472 PF11958.8 PIK61642.1 - 0.06 13.8 0.0 0.08 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3472) SRCR PF00530.18 PIK61643.1 - 1.3e-31 109.0 6.4 8.6e-28 96.8 1.3 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61643.1 - 2.7e-06 27.8 0.2 5.3e-06 26.9 0.2 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Rax2 PF12768.7 PIK61643.1 - 0.0088 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Hepsin-SRCR PF09272.10 PIK61643.1 - 0.036 14.6 0.0 0.074 13.6 0.0 1.5 1 0 0 1 1 1 0 Hepsin, SRCR domain TraL PF07178.11 PIK61643.1 - 0.055 13.9 0.3 0.13 12.8 0.3 1.5 1 0 0 1 1 1 0 TraL protein Syndecan PF01034.20 PIK61643.1 - 0.15 12.0 0.3 0.32 10.9 0.3 1.5 1 0 0 1 1 1 0 Syndecan domain Phage_Coat_Gp8 PF05371.12 PIK61643.1 - 0.16 11.8 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 SRCR PF00530.18 PIK61644.1 - 9.3e-17 61.4 0.0 1.7e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61644.1 - 7.3e-08 32.9 0.2 1.2e-07 32.1 0.2 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61644.1 - 0.0015 19.1 0.0 0.0027 18.2 0.0 1.4 1 0 0 1 1 1 1 Hepsin, SRCR domain SRCR PF00530.18 PIK61645.1 - 6.5e-25 87.6 0.5 5.4e-23 81.4 0.4 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61645.1 - 4.8e-05 23.8 0.5 0.00012 22.5 0.5 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Rax2 PF12768.7 PIK61645.1 - 0.0048 16.4 0.0 0.0074 15.8 0.0 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity TraL PF07178.11 PIK61645.1 - 0.034 14.6 0.2 0.084 13.4 0.2 1.6 1 0 0 1 1 1 0 TraL protein Phage_Coat_Gp8 PF05371.12 PIK61645.1 - 0.087 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage major coat protein, Gp8 DUF4690 PF15756.5 PIK61645.1 - 0.099 13.2 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Syndecan PF01034.20 PIK61645.1 - 0.13 12.2 0.3 0.26 11.3 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain Cytochrom_B559a PF00284.20 PIK61646.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit SYF2 PF08231.12 PIK61647.1 - 4e-54 183.3 17.7 4e-54 183.3 17.7 1.4 2 0 0 2 2 2 1 SYF2 splicing factor DUF2884 PF11101.8 PIK61647.1 - 0.02 14.4 0.3 0.03 13.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Ribosomal_S30AE PF02482.19 PIK61647.1 - 3.5 8.5 6.2 3.5 8.5 0.2 3.1 3 1 0 3 3 3 0 Sigma 54 modulation protein / S30EA ribosomal protein Myb_Cef PF11831.8 PIK61648.1 - 5.8e-71 238.8 21.4 5.8e-71 238.8 21.4 4.4 4 1 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 PIK61648.1 - 1.5e-19 69.9 5.3 2.5e-11 43.6 1.7 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK61648.1 - 3.3e-18 65.7 3.6 2.8e-12 46.7 3.3 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain LsmAD PF06741.13 PIK61650.1 - 2.4 8.8 4.5 7.7 7.2 1.6 2.5 2 0 0 2 2 2 0 LsmAD domain DUF1236 PF06823.12 PIK61651.1 - 0.01 15.7 2.0 19 5.2 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1236) TMEM191C PF15194.6 PIK61651.1 - 0.023 14.9 0.0 0.74 10.0 0.0 2.7 2 1 0 3 3 3 0 TMEM191C family DUF2846 PF11008.8 PIK61651.1 - 0.11 12.5 0.0 23 5.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2846) DUF1176 PF06674.11 PIK61651.1 - 0.16 11.4 1.2 14 5.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1176) SRRM_C PF15230.6 PIK61651.1 - 0.49 11.0 1.3 1.4e+02 3.2 0.1 3.2 3 0 0 3 3 3 0 Serine/arginine repetitive matrix protein C-terminus Bmt2 PF11968.8 PIK61653.1 - 8.9e-59 199.0 0.4 1.2e-58 198.5 0.4 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 PIK61653.1 - 7.5e-06 25.9 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 PIK61653.1 - 3.2e-05 23.9 0.1 4.4e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase FlxA PF14282.6 PIK61653.1 - 0.00025 21.0 1.9 0.00025 21.0 1.9 1.8 2 0 0 2 2 2 1 FlxA-like protein Methyltransf_11 PF08241.12 PIK61653.1 - 0.0011 19.5 0.0 0.0026 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF1542 PF07564.11 PIK61653.1 - 0.11 12.7 2.5 0.23 11.6 2.5 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF148 PF02520.17 PIK61653.1 - 3.6 7.7 9.1 0.062 13.4 1.7 1.9 3 0 0 3 3 3 0 Domain of unknown function DUF148 PhoD PF09423.10 PIK61654.1 - 0.0038 16.3 0.0 0.0045 16.0 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase DUF3048 PF11258.8 PIK61654.1 - 0.0085 16.2 0.0 0.076 13.1 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3048) N-terminal domain CobA_CobO_BtuR PF02572.15 PIK61654.1 - 0.088 13.1 0.0 9.3 6.5 0.0 2.1 1 1 1 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Ig_3 PF13927.6 PIK61655.1 - 5.4e-40 135.9 0.8 9.7e-14 51.7 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 PIK61655.1 - 9e-33 112.2 0.0 1.7e-13 50.4 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 PIK61655.1 - 6.3e-32 109.7 0.0 1.9e-09 37.7 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 PIK61655.1 - 2.4e-22 78.9 0.0 1.3e-07 31.7 0.0 4.7 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 PIK61655.1 - 1.6e-11 44.3 0.6 0.22 11.7 0.0 5.5 4 2 2 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK61655.1 - 2.9e-09 36.9 0.2 0.0079 16.2 0.0 3.6 2 1 1 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 PIK61655.1 - 2.5e-06 27.6 0.0 1.3 9.4 0.0 4.1 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 PIK61655.1 - 2e-05 24.6 0.1 0.58 10.1 0.0 4.4 2 2 1 3 3 3 1 CD47 immunoglobulin-like domain Ig_5 PF16681.5 PIK61655.1 - 4.9e-05 23.7 0.0 1 9.8 0.0 4.1 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain adh_short_C2 PF13561.6 PIK61656.1 - 6.8e-55 186.2 1.0 8.1e-55 185.9 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK61656.1 - 1.5e-39 135.5 1.2 1.8e-39 135.2 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK61656.1 - 3.2e-05 23.9 0.2 7e-05 22.8 0.2 1.6 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 PIK61656.1 - 0.00019 21.7 0.1 0.00048 20.4 0.1 1.7 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 PIK61656.1 - 0.0038 17.1 0.1 0.0052 16.7 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 PIK61656.1 - 0.0088 16.0 0.5 0.017 15.1 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 PIK61656.1 - 0.024 13.9 0.2 0.041 13.2 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amidase PF01425.21 PIK61657.1 - 2.9e-71 240.8 0.0 3.5e-71 240.5 0.0 1.1 1 0 0 1 1 1 1 Amidase fn3 PF00041.21 PIK61661.1 - 0.0016 18.8 0.1 0.0051 17.1 0.1 2.0 1 0 0 1 1 1 1 Fibronectin type III domain IQ PF00612.27 PIK61661.1 - 0.0018 17.9 0.0 0.0042 16.8 0.0 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif bZIP_2 PF07716.15 PIK61661.1 - 0.0096 16.0 1.5 0.067 13.3 1.5 2.6 1 0 0 1 1 1 1 Basic region leucine zipper WXG100 PF06013.12 PIK61661.1 - 2.4 8.4 10.6 0.46 10.8 5.1 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Vinculin PF01044.19 PIK61662.1 - 1.9e-17 62.9 0.2 2.2e-17 62.6 0.2 1.0 1 0 0 1 1 1 1 Vinculin family Serine_rich PF08824.10 PIK61662.1 - 0.012 15.6 0.8 0.024 14.7 0.8 1.6 1 1 0 1 1 1 0 Serine rich protein interaction domain Cyt_bd_oxida_I PF01654.17 PIK61662.1 - 0.16 10.5 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I Vinculin PF01044.19 PIK61663.1 - 1.2e-30 106.6 1.3 7.3e-17 61.0 0.0 2.8 2 1 0 3 3 3 2 Vinculin family Hormone_1 PF00103.20 PIK61663.1 - 0.011 15.4 2.7 0.021 14.5 0.3 2.4 3 0 0 3 3 3 0 Somatotropin hormone family Serine_rich PF08824.10 PIK61663.1 - 0.045 13.7 7.5 2.8 7.9 0.1 3.9 5 0 0 5 5 5 0 Serine rich protein interaction domain YtxH PF12732.7 PIK61663.1 - 0.71 10.4 3.3 17 6.0 0.1 3.4 4 0 0 4 4 4 0 YtxH-like protein DUF3314 PF11771.8 PIK61664.1 - 0.44 10.7 3.1 1 9.4 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) Cupin_8 PF13621.6 PIK61664.1 - 3.1 7.4 6.7 5.2 6.7 6.7 1.5 1 0 0 1 1 1 0 Cupin-like domain Merozoite_SPAM PF07133.11 PIK61665.1 - 0.32 11.0 21.3 0.68 9.9 21.3 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Adeno_terminal PF02459.15 PIK61665.1 - 0.41 9.0 6.1 0.56 8.5 6.1 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein TRAP_alpha PF03896.16 PIK61665.1 - 1.5 7.9 5.8 2.7 7.1 5.8 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sporozoite_P67 PF05642.11 PIK61665.1 - 2.3 6.2 16.8 2.7 6.0 15.9 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen HSP90 PF00183.18 PIK61665.1 - 5.5 5.8 12.3 8.1 5.2 12.3 1.2 1 0 0 1 1 1 0 Hsp90 protein DUF3682 PF12446.8 PIK61668.1 - 0.0083 16.6 4.6 0.014 15.8 4.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) XRCC4 PF06632.12 PIK61668.1 - 0.35 9.7 11.1 0.39 9.5 10.8 1.2 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Nucleo_P87 PF07267.11 PIK61668.1 - 4.4 6.0 11.7 4.9 5.9 11.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4551 PF15087.6 PIK61669.1 - 0.24 10.2 7.7 0.31 9.8 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TUTF7_u4 PF16631.5 PIK61669.1 - 1.2 9.8 16.6 0.19 12.4 10.7 2.3 2 1 0 2 2 2 0 Unstructured region 4 on terminal uridylyltransferase 7 SLC12 PF03522.15 PIK61669.1 - 9.9 5.1 7.4 11 5.0 7.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4629 PF15442.6 PIK61670.1 - 0.51 10.6 9.3 0.8 9.9 7.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) CUB PF00431.20 PIK61671.1 - 4.1e-35 120.5 0.1 5.4e-16 58.9 0.0 3.3 2 1 1 3 3 3 3 CUB domain CRF-BP PF05428.11 PIK61671.1 - 0.0067 15.3 0.0 0.011 14.5 0.0 1.4 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) Macoilin PF09726.9 PIK61671.1 - 0.25 9.8 9.6 0.29 9.6 9.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF932 PF06067.11 PIK61672.1 - 0.0032 17.3 0.3 0.0046 16.7 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF932) ZnuA PF01297.17 PIK61672.1 - 0.0052 16.2 0.2 0.0057 16.1 0.2 1.1 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic BBP1_C PF15272.6 PIK61672.1 - 0.009 15.9 0.3 0.011 15.6 0.3 1.2 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal THOC7 PF05615.13 PIK61672.1 - 0.022 15.0 1.0 0.04 14.2 1.0 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 FlxA PF14282.6 PIK61672.1 - 0.047 13.7 7.3 0.072 13.1 7.3 1.3 1 0 0 1 1 1 0 FlxA-like protein SlyX PF04102.12 PIK61672.1 - 0.15 12.7 1.8 0.3 11.7 1.8 1.5 1 0 0 1 1 1 0 SlyX HMG_box_2 PF09011.10 PIK61673.1 - 0.0016 19.0 3.3 0.0025 18.3 2.6 1.7 1 1 0 1 1 1 1 HMG-box domain DUF3106 PF11304.8 PIK61673.1 - 0.0034 17.8 0.6 0.0075 16.7 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3106) Protamine_like PF06382.11 PIK61673.1 - 0.013 15.7 0.1 0.021 15.0 0.1 1.3 1 0 0 1 1 1 0 Protamine and protamine like Rotamase_3 PF13616.6 PIK61673.1 - 0.036 14.6 0.1 0.12 12.9 0.0 1.8 1 1 1 2 2 2 0 PPIC-type PPIASE domain HMG_box PF00505.19 PIK61673.1 - 0.074 13.5 1.8 0.22 12.0 1.4 2.1 1 1 0 1 1 1 0 HMG (high mobility group) box KDZ PF18758.1 PIK61674.1 - 5.3e-21 75.2 0.1 2.6e-17 63.2 0.1 2.9 3 0 0 3 3 3 2 Kyakuja-Dileera-Zisupton transposase CxC2 PF18803.1 PIK61674.1 - 8e-12 45.3 0.0 3.5e-11 43.2 0.0 2.1 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 PIK61674.1 - 1.6e-06 27.9 1.1 0.00027 20.8 0.1 3.0 2 0 0 2 2 2 2 CxC3 like cysteine cluster associated with KDZ transposases CxC1 PF18802.1 PIK61674.1 - 1.8e-05 24.8 0.2 8e-05 22.7 0.2 2.1 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases Transp_Tc5_C PF04236.15 PIK61674.1 - 0.041 14.2 1.0 0.12 12.8 1.0 1.8 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain DUF3091 PF11291.8 PIK61674.1 - 0.33 11.1 2.9 0.41 10.8 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3091) RVT_1 PF00078.27 PIK61675.1 - 2.8e-08 33.6 0.1 4.4e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ERp29 PF07749.12 PIK61675.1 - 0.016 16.1 0.3 0.021 15.7 0.3 1.3 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Mt_ATP_synt PF15704.5 PIK61675.1 - 0.034 14.0 0.1 0.04 13.8 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit Creatininase PF02633.14 PIK61676.1 - 0.022 14.2 0.2 0.039 13.4 0.2 1.3 1 0 0 1 1 1 0 Creatinine amidohydrolase Glyco_transf_10 PF00852.19 PIK61678.1 - 6.1e-20 71.7 0.0 8.3e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK61678.1 - 2.1e-06 28.1 0.1 4.4e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 PIK61679.1 - 1.7e-43 148.4 0.0 2.6e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK61679.1 - 6.3e-06 26.6 0.1 1.2e-05 25.7 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal NACHT PF05729.12 PIK61680.1 - 4.4e-07 30.0 0.1 8e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 NACHT domain Flavi_glycop_C PF02832.16 PIK61680.1 - 0.0029 17.7 0.0 0.0071 16.5 0.0 1.6 1 0 0 1 1 1 1 Flavivirus glycoprotein, immunoglobulin-like domain AAA_22 PF13401.6 PIK61680.1 - 0.01 16.1 0.1 0.031 14.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 PIK61680.1 - 0.028 14.1 0.1 0.066 12.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain RVT_1 PF00078.27 PIK61680.1 - 0.052 13.0 0.1 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CSL PF05207.13 PIK61680.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 CSL zinc finger RraB PF06877.11 PIK61680.1 - 0.071 13.8 0.3 1.7 9.4 0.0 2.8 3 0 0 3 3 3 0 Regulator of ribonuclease activity B AAA_16 PF13191.6 PIK61680.1 - 0.18 12.1 0.0 12 6.3 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain TPR_2 PF07719.17 PIK61681.1 - 3.5e-05 23.6 5.9 0.29 11.4 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61681.1 - 8.5e-05 22.8 1.0 0.056 13.7 0.1 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61681.1 - 0.002 18.6 2.2 0.2 12.2 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK61681.1 - 0.009 16.6 1.8 15 6.5 0.2 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61681.1 - 0.023 14.5 9.1 0.073 12.9 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61681.1 - 0.027 15.1 0.0 2.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61681.1 - 0.3 11.4 9.4 1.3 9.4 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK61681.1 - 1.2 9.1 6.8 38 4.3 0.4 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF2508 PF10704.9 PIK61681.1 - 1.6 9.0 6.6 4.9 7.4 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF2508) TPR_14 PF13428.6 PIK61682.1 - 0.00096 19.8 0.4 0.41 11.6 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat PIP49_N PF14875.6 PIK61682.1 - 0.1 12.5 0.0 0.24 11.2 0.0 1.6 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 TPR_19 PF14559.6 PIK61683.1 - 0.00092 19.7 1.7 0.048 14.2 0.1 3.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61683.1 - 0.0017 18.4 5.3 5 7.5 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61683.1 - 0.0022 18.3 0.2 3 8.2 0.3 3.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 PIK61683.1 - 0.01 16.5 0.0 0.027 15.1 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 PIK61683.1 - 0.055 14.1 1.4 3.4 8.5 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5475 PF17569.2 PIK61683.1 - 0.062 13.6 0.1 0.19 12.0 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5475) TPR_1 PF00515.28 PIK61683.1 - 0.064 13.1 8.1 0.34 10.8 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61683.1 - 0.082 12.6 0.5 7.2 6.4 0.0 3.3 3 0 0 3 3 3 0 TPR repeat DUF2508 PF10704.9 PIK61683.1 - 0.15 12.3 2.5 1.9 8.7 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2508) TPR_16 PF13432.6 PIK61684.1 - 9.5e-05 23.0 0.0 0.047 14.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61684.1 - 0.0012 19.1 6.7 3.8 7.9 0.1 5.6 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61684.1 - 0.0065 17.0 11.8 2.5 8.7 0.1 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 PIK61684.1 - 0.012 16.2 6.3 14 6.6 0.5 6.7 7 2 0 7 7 7 0 Tetratricopeptide repeat MIT PF04212.18 PIK61684.1 - 0.054 13.6 5.8 5.1 7.2 0.0 4.6 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Cytochrom_B562 PF07361.11 PIK61684.1 - 0.21 12.3 2.1 3 8.6 0.1 3.5 4 0 0 4 4 4 0 Cytochrome b562 TPR_2 PF07719.17 PIK61684.1 - 0.29 11.3 19.8 8.7 6.7 0.0 7.8 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61684.1 - 2.5 8.1 15.7 0.52 10.2 0.1 6.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61684.1 - 2.6 7.8 6.5 21 4.9 0.0 5.1 6 1 0 6 6 6 0 TPR repeat Rh5 PF18515.1 PIK61685.1 - 4.4e-10 39.3 59.9 0.017 14.4 13.3 6.0 1 1 4 5 5 5 5 Rh5 coiled-coil domain IL11 PF07400.11 PIK61685.1 - 3.5e-07 30.0 4.6 6.7 6.3 0.1 6.4 1 1 6 7 7 7 0 Interleukin 11 DUF1664 PF07889.12 PIK61685.1 - 9.1e-07 28.9 2.6 0.099 12.7 1.1 3.7 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) RPW8 PF05659.11 PIK61685.1 - 9.6e-07 28.6 11.0 0.21 11.2 0.9 4.7 1 1 4 5 5 5 4 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fzo_mitofusin PF04799.13 PIK61685.1 - 6.4e-06 25.8 0.5 1.8 8.1 0.1 4.2 1 1 2 3 3 3 2 fzo-like conserved region Laminin_I PF06008.14 PIK61685.1 - 1.8e-05 24.6 6.0 0.47 10.1 0.5 4.5 1 1 4 5 5 5 2 Laminin Domain I SKA2 PF16740.5 PIK61685.1 - 3e-05 23.8 2.3 0.61 9.9 0.3 3.9 1 1 2 3 3 3 2 Spindle and kinetochore-associated protein 2 FlaC_arch PF05377.11 PIK61685.1 - 0.00024 21.4 8.5 5.2 7.6 0.7 5.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 PIK61685.1 - 0.00032 21.0 5.6 5.9 7.3 0.1 4.7 2 1 3 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BORCS7 PF16088.5 PIK61685.1 - 0.00038 20.7 2.1 14 6.0 0.0 4.5 1 1 4 5 5 5 0 BLOC-1-related complex sub-unit 7 V-SNARE PF05008.15 PIK61685.1 - 0.00041 20.7 11.6 11 6.5 0.2 6.4 1 1 6 7 7 7 0 Vesicle transport v-SNARE protein N-terminus RPN5_C PF18098.1 PIK61685.1 - 0.00059 19.9 28.8 3 8.0 0.3 10.0 3 3 9 12 12 12 3 26S proteasome regulatory subunit RPN5 C-terminal domain Syntaxin_2 PF14523.6 PIK61685.1 - 0.00076 19.8 7.5 0.94 9.9 1.0 4.2 1 1 2 3 3 3 1 Syntaxin-like protein DUF16 PF01519.16 PIK61685.1 - 0.00088 19.7 1.0 1.5 9.4 1.0 3.3 1 1 0 1 1 1 1 Protein of unknown function DUF16 ISG65-75 PF11727.8 PIK61685.1 - 0.0011 18.3 9.4 4.6 6.4 0.1 4.4 1 1 2 3 3 3 0 Invariant surface glycoprotein AI-2E_transport PF01594.16 PIK61685.1 - 0.0011 18.1 15.2 1.5 7.9 2.6 4.9 1 1 1 2 2 2 1 AI-2E family transporter MCPsignal PF00015.21 PIK61685.1 - 0.0012 18.7 0.0 1.5 8.6 0.0 2.8 1 1 3 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3540 PF12059.8 PIK61685.1 - 0.0014 18.5 0.0 14 5.4 0.0 3.3 1 1 4 5 5 5 0 Protein of unknown function (DUF3540) bZIP_1 PF00170.21 PIK61685.1 - 0.0015 18.6 3.5 32 4.7 0.1 4.9 2 1 3 5 5 5 0 bZIP transcription factor STAT_alpha PF01017.20 PIK61685.1 - 0.0025 17.7 1.9 1.4 8.8 1.9 3.6 1 1 0 1 1 1 1 STAT protein, all-alpha domain Tropomyosin PF00261.20 PIK61685.1 - 0.0038 16.6 6.9 0.09 12.1 0.6 2.3 1 1 1 2 2 2 2 Tropomyosin Nup88 PF10168.9 PIK61685.1 - 0.004 15.0 6.7 0.22 9.3 1.3 2.2 1 1 1 2 2 2 2 Nuclear pore component DUF1465 PF07323.12 PIK61685.1 - 0.0062 16.4 5.3 5.3 6.9 0.5 4.4 1 1 4 5 5 5 0 Protein of unknown function (DUF1465) DUF3847 PF12958.7 PIK61685.1 - 0.0097 16.0 6.8 25 5.1 1.0 5.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3847) PLU-1 PF08429.11 PIK61685.1 - 0.01 15.1 3.5 0.071 12.3 3.5 2.3 1 1 0 1 1 1 0 PLU-1-like protein DUF4298 PF14131.6 PIK61685.1 - 0.011 15.6 8.0 17 5.5 0.1 4.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4298) ZapB PF06005.12 PIK61685.1 - 0.011 16.1 24.5 4.6 7.7 2.2 6.9 2 2 1 4 4 4 0 Cell division protein ZapB HCR PF07111.12 PIK61685.1 - 0.019 13.1 0.3 3.9 5.4 0.1 3.2 1 1 1 2 2 2 0 Alpha helical coiled-coil rod protein (HCR) DUF848 PF05852.11 PIK61685.1 - 0.032 14.3 5.3 5 7.2 0.7 3.4 1 1 3 4 4 4 0 Gammaherpesvirus protein of unknown function (DUF848) JIP_LZII PF16471.5 PIK61685.1 - 0.073 13.3 15.3 43 4.4 4.0 6.4 2 1 2 4 4 4 0 JNK-interacting protein leucine zipper II FliD_C PF07195.12 PIK61685.1 - 0.084 12.3 0.8 5.4 6.4 0.1 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Laminin_II PF06009.12 PIK61685.1 - 0.091 12.8 9.1 8.1 6.5 0.3 3.4 1 1 2 3 3 3 0 Laminin Domain II Med8 PF10232.9 PIK61685.1 - 0.3 10.6 7.5 34 3.9 0.1 4.8 1 1 6 7 7 7 0 Mediator of RNA polymerase II transcription complex subunit 8 YabA PF06156.13 PIK61685.1 - 0.39 11.4 6.5 19 6.0 0.8 4.0 1 1 1 3 3 3 0 Initiation control protein YabA XhlA PF10779.9 PIK61685.1 - 0.64 10.3 16.6 8.5 6.7 0.1 4.7 1 1 2 3 3 3 0 Haemolysin XhlA WASH_WAHD PF11945.8 PIK61685.1 - 1 8.8 27.1 2.6 7.5 3.2 4.2 1 1 2 3 3 3 0 WAHD domain of WASH complex KASH_CCD PF14662.6 PIK61685.1 - 1.1 9.1 6.8 4.6 7.0 1.3 2.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF5082 PF16888.5 PIK61685.1 - 1.6 9.1 34.2 7 6.9 1.8 5.2 1 1 3 5 5 5 0 Domain of unknown function (DUF5082) CCDC106 PF15794.5 PIK61685.1 - 2 8.1 20.7 14 5.3 0.7 4.9 1 1 4 5 5 5 0 Coiled-coil domain-containing protein 106 GerPC PF10737.9 PIK61685.1 - 3.2 7.8 31.6 32 4.5 3.2 5.8 1 1 3 4 4 3 0 Spore germination protein GerPC Plasmod_dom_1 PF09715.10 PIK61685.1 - 3.8 7.6 62.8 37 4.5 0.2 13.1 4 1 7 13 13 13 0 Plasmodium protein of unknown function (Plasmod_dom_1) DUF1938 PF09153.10 PIK61685.1 - 8.3 6.6 25.4 34 4.6 0.6 5.8 1 1 2 3 3 3 0 Domain of unknown function (DUF1938) DUF4988 PF16378.5 PIK61685.1 - 8.5 6.0 18.9 11 5.7 0.2 4.7 1 1 2 3 3 3 0 Domain of unknown function DUF4800 PF16057.5 PIK61685.1 - 8.8 5.5 10.3 25 4.0 1.0 3.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4800) CUB PF00431.20 PIK61686.1 - 6e-08 33.0 0.0 4e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 CUB domain HYR PF02494.16 PIK61687.1 - 1.1e-76 253.2 19.3 1.1e-23 83.3 4.0 4.2 4 0 0 4 4 4 4 HYR domain DUF5011 PF16403.5 PIK61687.1 - 1.6e-05 24.9 0.4 1.8 8.7 0.1 3.8 4 0 0 4 4 4 3 Domain of unknown function (DUF5011) HYR PF02494.16 PIK61688.1 - 3.6e-149 485.5 58.3 6.5e-23 80.9 2.0 9.0 9 0 0 9 9 9 9 HYR domain Cadherin_3 PF16184.5 PIK61688.1 - 0.00018 21.4 0.5 27 4.8 0.0 5.6 6 0 0 6 6 6 1 Cadherin-like DUF5011 PF16403.5 PIK61688.1 - 0.00024 21.2 0.1 8.2 6.6 0.1 5.6 7 0 0 7 7 7 1 Domain of unknown function (DUF5011) Spindle_Spc25 PF08234.12 PIK61688.1 - 0.02 15.1 0.0 3.2 8.0 0.0 2.9 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 HYR PF02494.16 PIK61689.1 - 1.7e-47 159.6 31.9 2.2e-17 63.1 4.8 6.1 6 0 0 6 6 6 5 HYR domain EGF PF00008.27 PIK61689.1 - 6.7e-32 109.4 227.9 5.4e-05 23.4 11.1 14.4 13 1 0 13 13 13 12 EGF-like domain ABC_tran PF00005.27 PIK61690.1 - 6.8e-30 104.4 4.0 1.3e-22 80.8 0.0 3.6 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 PIK61690.1 - 0.00033 20.4 3.9 0.00062 19.5 3.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_29 PF13555.6 PIK61690.1 - 0.23 11.2 0.5 0.85 9.4 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain U1snRNP70_N PF12220.8 PIK61690.1 - 6.2 7.5 7.4 2.9 8.6 0.8 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal ABC_membrane PF00664.23 PIK61691.1 - 5.4e-26 91.9 15.2 7.1e-26 91.5 13.9 1.8 1 1 1 2 2 2 1 ABC transporter transmembrane region DUF4672 PF15716.5 PIK61691.1 - 0.07 12.8 0.6 0.4 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) DUP PF00674.18 PIK61691.1 - 6 7.1 6.8 0.54 10.4 0.7 2.4 2 1 0 2 2 2 0 DUP family Dynein_C PF18199.1 PIK61692.1 - 7.3e-99 330.9 0.0 1.8e-98 329.6 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 PIK61692.1 - 1.4e-54 184.4 0.2 2.5e-54 183.5 0.2 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 PIK61692.1 - 1.4e-43 147.7 0.1 4.8e-43 146.0 0.1 2.0 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_9 PF12781.7 PIK61692.1 - 3.6e-10 39.4 3.2 8.7e-08 31.6 0.5 2.8 3 0 0 3 3 3 2 ATP-binding dynein motor region DHC_N1 PF08385.12 PIK61693.1 - 8.4e-163 543.0 26.1 9e-155 516.5 9.0 4.1 3 1 1 4 4 4 3 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 PIK61693.1 - 1.6e-146 487.4 0.0 8.5e-145 481.8 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 PIK61693.1 - 1.9e-115 386.2 10.6 1.9e-115 386.2 10.6 3.7 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 PIK61693.1 - 9.6e-93 310.2 0.0 4.2e-92 308.1 0.0 2.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 PIK61693.1 - 1.3e-68 230.0 1.6 4.6e-63 212.0 0.1 3.9 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 PIK61693.1 - 1.2e-28 100.2 10.8 1.2e-28 100.2 10.8 2.4 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 PIK61693.1 - 4.3e-24 85.0 0.0 9.1e-22 77.5 0.0 3.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 PIK61693.1 - 4e-20 72.2 0.1 7.7e-06 26.0 0.0 5.8 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 PIK61693.1 - 5.5e-17 61.8 0.0 2.3e-16 59.8 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 PIK61693.1 - 1.9e-06 28.3 0.1 1.4 9.4 0.0 5.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK61693.1 - 1.3e-05 25.5 0.4 4.4 7.6 0.0 5.1 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 PIK61693.1 - 0.021 15.2 0.1 25 5.3 0.0 4.1 3 0 0 3 3 3 0 RNA helicase Roc PF08477.13 PIK61693.1 - 0.093 12.9 0.1 23 5.3 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase CDC45 PF02724.14 PIK61693.1 - 0.33 9.2 13.0 0.85 7.8 13.0 1.6 1 0 0 1 1 1 0 CDC45-like protein DUF948 PF06103.11 PIK61693.1 - 5.1 7.4 21.3 1.7e+02 2.6 0.1 8.3 8 0 0 8 8 8 0 Bacterial protein of unknown function (DUF948) GCP_C_terminal PF04130.13 PIK61694.1 - 1.5e-80 271.0 12.2 1.5e-80 271.0 12.2 2.0 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 PIK61694.1 - 4.2e-77 259.8 0.2 8.6e-77 258.8 0.2 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal BROMI PF14961.6 PIK61695.1 - 2.5e-20 71.6 0.1 2.9e-20 71.5 0.1 1.0 1 0 0 1 1 1 1 Broad-minded protein Nod1 PF17114.5 PIK61695.1 - 0.077 13.1 0.0 0.12 12.5 0.0 1.4 1 1 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 BROMI PF14961.6 PIK61696.1 - 6.4e-102 342.0 4.3 7.5e-102 341.7 4.3 1.0 1 0 0 1 1 1 1 Broad-minded protein HEAT_2 PF13646.6 PIK61696.1 - 0.34 11.3 1.8 34 4.9 0.1 3.4 3 1 0 3 3 3 0 HEAT repeats BROMI PF14961.6 PIK61697.1 - 3.6e-34 117.5 0.0 4.1e-23 80.9 0.0 2.0 2 0 0 2 2 2 2 Broad-minded protein BROMI PF14961.6 PIK61698.1 - 3.6e-112 375.9 4.4 6e-63 212.9 0.8 3.0 2 1 1 3 3 3 3 Broad-minded protein BROMI PF14961.6 PIK61699.1 - 2.3e-103 346.8 0.0 1.6e-55 188.2 0.0 2.0 1 1 1 2 2 2 2 Broad-minded protein Aa_trans PF01490.18 PIK61700.1 - 2.8e-39 135.0 5.1 2.8e-39 135.0 5.1 1.8 1 1 0 2 2 2 1 Transmembrane amino acid transporter protein DUF4199 PF13858.6 PIK61700.1 - 2.2 8.6 10.5 0.16 12.4 4.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) DUF485 PF04341.12 PIK61700.1 - 7.1 6.7 11.2 11 6.0 0.9 3.7 3 1 0 3 3 3 0 Protein of unknown function, DUF485 SRP68 PF16969.5 PIK61701.1 - 1.1e-79 268.9 0.6 1.3e-79 268.7 0.6 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 CK2S PF15011.6 PIK61701.1 - 0.032 14.1 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Casein Kinase 2 substrate PLDc_2 PF13091.6 PIK61702.1 - 5.7e-06 26.3 0.0 7.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 PIK61703.1 - 0.0041 17.0 0.0 0.0062 16.4 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PP-binding PF00550.25 PIK61704.1 - 3.1e-11 43.5 1.0 4.8e-11 42.8 1.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 PIK61704.1 - 0.011 16.0 2.6 0.025 14.8 2.6 1.6 1 1 0 1 1 1 0 Acyl-carrier Ribosomal_L12_N PF16320.5 PIK61704.1 - 0.096 12.4 0.5 0.29 10.9 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Death PF00531.22 PIK61705.1 - 1.9e-06 27.9 0.0 4.6e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Death domain GASA PF02704.14 PIK61705.1 - 0.4 10.9 8.9 0.21 11.8 0.6 2.8 2 0 0 2 2 2 0 Gibberellin regulated protein Ras PF00071.22 PIK61706.1 - 8.4e-29 100.3 0.0 1.1e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK61706.1 - 1e-12 48.3 0.0 1.7e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Kinesin PF00225.23 PIK61707.1 - 7.9e-48 163.1 0.0 9.6e-48 162.8 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK61707.1 - 3.8e-29 101.5 0.0 4.8e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Microtubule binding ResIII PF04851.15 PIK61707.1 - 0.045 13.7 0.1 0.088 12.8 0.1 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF4444 PF14563.6 PIK61707.1 - 0.076 12.7 0.1 0.66 9.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4444) Circo_capsid PF02443.15 PIK61707.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Circovirus capsid protein Kinesin PF00225.23 PIK61708.1 - 3.4e-42 144.5 0.0 5.1e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF5082 PF16888.5 PIK61708.1 - 0.012 15.9 1.6 0.02 15.1 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF1796 PF08795.10 PIK61708.1 - 0.016 15.2 1.1 0.028 14.4 0.2 1.8 1 1 1 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) DUF1192 PF06698.11 PIK61708.1 - 0.024 14.7 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Flp_N PF03930.14 PIK61708.1 - 0.027 14.4 0.3 0.044 13.7 0.3 1.4 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus KASH_CCD PF14662.6 PIK61708.1 - 0.027 14.3 0.6 0.038 13.8 0.6 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TAXi_C PF14541.6 PIK61708.1 - 0.035 13.9 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Fib_alpha PF08702.10 PIK61708.1 - 0.065 13.4 0.5 0.1 12.8 0.5 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CCDC144C PF14915.6 PIK61708.1 - 0.069 12.3 1.9 0.096 11.8 1.9 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region FadA PF09403.10 PIK61708.1 - 0.076 13.5 3.8 0.12 12.9 3.8 1.3 1 0 0 1 1 1 0 Adhesion protein FadA Phage_tail_S PF05069.13 PIK61709.1 - 0.061 13.2 2.2 0.33 10.8 0.1 2.5 2 0 0 2 2 2 0 Phage virion morphogenesis family Guanylin PF02058.15 PIK61709.1 - 5.9 7.4 7.6 6.6 7.3 0.2 2.9 3 0 0 3 3 3 0 Guanylin precursor Ras PF00071.22 PIK61710.1 - 6.3e-42 142.9 0.0 8.8e-42 142.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK61710.1 - 1.3e-16 60.9 0.0 1.9e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK61710.1 - 1.9e-05 24.2 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 PIK61710.1 - 2.3e-05 24.5 0.0 3.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 PIK61710.1 - 0.0012 18.4 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 PIK61710.1 - 0.0094 15.9 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Aconitase PF00330.20 PIK61711.1 - 6.4e-151 503.5 0.0 8.6e-151 503.0 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 PIK61711.1 - 1.6e-44 151.4 0.0 3.3e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Sulfotransfer_1 PF00685.27 PIK61712.1 - 1e-08 35.0 0.0 1.5e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK61712.1 - 0.0032 17.9 0.0 1.9 8.8 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK61712.1 - 0.0066 16.4 0.1 0.011 15.7 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Corona_nucleoca PF00937.18 PIK61712.1 - 0.029 13.4 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Sulfotransfer_1 PF00685.27 PIK61713.1 - 2.3e-19 69.9 0.1 3.4e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK61713.1 - 1e-09 39.2 1.0 0.00056 20.3 0.5 3.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK61713.1 - 0.033 14.1 0.3 0.076 12.9 0.3 1.6 1 0 0 1 1 1 0 Sulfotransferase family Amino_oxidase PF01593.24 PIK61714.1 - 3.6e-54 184.7 0.0 5.6e-54 184.1 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 PIK61714.1 - 1.3e-12 47.7 0.1 3.5e-12 46.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 PIK61714.1 - 5.8e-08 32.3 0.0 1.4e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 PIK61714.1 - 1.4e-07 31.5 0.0 3.4e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 PIK61714.1 - 0.00013 21.2 0.1 0.0002 20.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 PIK61714.1 - 0.00021 20.1 0.0 0.0019 17.0 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 PIK61714.1 - 0.00072 18.9 0.0 0.012 14.9 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 PIK61714.1 - 0.0021 17.2 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 PIK61714.1 - 0.0039 17.7 0.0 0.013 16.1 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 PIK61714.1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK61714.1 - 0.066 12.3 0.1 0.26 10.3 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A MCRA PF06100.11 PIK61714.1 - 0.11 11.3 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 MCRA family NAD_binding_9 PF13454.6 PIK61714.1 - 0.16 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Mqo PF06039.15 PIK61714.1 - 0.16 10.5 0.0 0.25 9.9 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) LRR_8 PF13855.6 PIK61715.1 - 3.3e-37 126.1 59.0 1.3e-08 34.5 4.4 8.7 3 2 5 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 PIK61715.1 - 6e-23 80.5 65.8 1.4e-05 25.4 4.0 10.1 6 2 6 12 12 12 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK61715.1 - 7.2e-08 32.1 24.2 0.0011 18.5 3.4 4.1 2 2 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 PIK61715.1 - 9.2e-05 22.5 62.9 0.46 11.2 1.0 14.7 13 3 1 14 14 14 3 Leucine Rich Repeat LRR_5 PF13306.6 PIK61715.1 - 0.016 15.2 7.5 1.2 9.1 0.1 3.2 2 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) adh_short_C2 PF13561.6 PIK61716.1 - 7.9e-48 163.0 0.2 1e-47 162.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 PIK61716.1 - 1.7e-45 154.9 0.5 2e-45 154.7 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK61716.1 - 9.2e-11 42.0 0.0 1.2e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 PIK61716.1 - 0.025 14.8 0.0 0.06 13.6 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Coatomer_WDAD PF04053.14 PIK61717.1 - 2.4e-09 36.8 8.5 0.0028 16.8 1.6 3.9 3 1 1 4 4 4 3 Coatomer WD associated region ANAPC4_WD40 PF12894.7 PIK61717.1 - 2.2e-08 34.2 4.1 0.00017 21.8 0.4 5.6 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 PIK61717.1 - 6.4e-05 22.8 13.7 0.37 11.0 1.3 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat Clathrin PF00637.20 PIK61717.1 - 0.00016 21.5 10.1 2.8 7.8 0.8 4.8 3 1 2 5 5 5 3 Region in Clathrin and VPS TPR_8 PF13181.6 PIK61717.1 - 0.00037 20.5 5.6 15 6.1 0.3 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61717.1 - 0.0015 18.3 9.0 0.22 11.4 0.4 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat WD40 PF00400.32 PIK61717.1 - 0.036 15.0 10.8 50 5.0 0.0 6.1 7 0 0 7 7 7 0 WD domain, G-beta repeat TPR_12 PF13424.6 PIK61717.1 - 0.15 12.3 15.6 4.3 7.7 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK61717.1 - 0.28 11.3 10.3 8.8 6.6 0.5 6.2 6 1 1 7 7 7 0 Tetratricopeptide repeat PPR_2 PF13041.6 PIK61718.1 - 0.0033 17.6 0.1 0.016 15.4 0.0 2.1 2 0 0 2 2 2 1 PPR repeat family RRP36 PF06102.12 PIK61718.1 - 0.0061 16.5 1.4 0.078 12.9 0.0 2.1 1 1 1 2 2 2 1 rRNA biogenesis protein RRP36 PPR PF01535.20 PIK61718.1 - 0.03 14.6 0.3 0.12 12.6 0.1 2.2 2 0 0 2 2 2 0 PPR repeat MFS_1_like PF12832.7 PIK61719.1 - 4.6e-59 200.2 7.6 6e-59 199.8 7.6 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 PIK61719.1 - 1.1e-17 64.1 20.9 1.2e-14 54.0 4.8 3.3 2 1 0 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 PIK61719.1 - 1.4e-11 44.1 11.1 3.2e-11 42.8 8.3 2.2 2 1 0 2 2 2 1 Nucleoside H+ symporter MFS_4 PF06779.14 PIK61719.1 - 4.4e-05 23.0 3.3 8e-05 22.1 3.3 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB LacY_symp PF01306.19 PIK61719.1 - 4.8e-05 22.3 12.4 0.00017 20.5 6.2 3.0 2 1 1 3 3 3 2 LacY proton/sugar symporter DUF1751 PF08551.10 PIK61720.1 - 0.0095 16.5 0.3 0.018 15.6 0.3 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) WD40 PF00400.32 PIK61721.1 - 2.4e-25 88.3 23.7 1.5e-07 32.0 1.2 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat WD40_like PF17005.5 PIK61721.1 - 3.4e-06 26.6 1.4 6.1e-06 25.8 1.4 1.4 1 0 0 1 1 1 1 WD40-like domain PQQ_3 PF13570.6 PIK61721.1 - 0.00013 22.3 4.5 4 8.1 0.1 6.2 5 1 3 8 8 8 1 PQQ-like domain Nup160 PF11715.8 PIK61721.1 - 0.0044 15.7 5.4 0.032 12.9 0.0 3.5 2 1 1 4 4 4 1 Nucleoporin Nup120/160 zf-C3HC4_3 PF13920.6 PIK61722.1 - 1.6e-06 27.9 5.5 1.6e-06 27.9 5.5 3.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK61722.1 - 3.9e-05 23.4 8.8 3.9e-05 23.4 8.8 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK61722.1 - 0.00015 21.7 10.5 0.00021 21.2 7.7 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 PIK61722.1 - 0.00055 19.7 6.7 0.00055 19.7 6.7 3.5 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 PIK61722.1 - 0.0013 18.7 8.5 0.0013 18.7 8.5 3.2 3 0 0 3 3 3 1 zinc-RING finger domain zf-TRAF PF02176.18 PIK61722.1 - 0.0032 18.1 10.3 0.0032 18.1 10.3 3.2 3 0 0 3 3 2 1 TRAF-type zinc finger zf-C3HC4 PF00097.25 PIK61722.1 - 0.0033 17.3 8.8 0.0033 17.3 8.8 3.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 PIK61722.1 - 0.0039 17.3 6.4 0.0039 17.3 6.4 2.8 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING Orf78 PF06024.12 PIK61722.1 - 0.004 17.4 0.1 0.0085 16.4 0.1 1.6 1 0 0 1 1 1 1 Orf78 (ac78) Sina PF03145.16 PIK61722.1 - 0.01 15.8 10.2 0.088 12.7 0.5 2.5 1 1 1 2 2 2 0 Seven in absentia protein family zf-RING_6 PF14835.6 PIK61722.1 - 0.012 15.4 1.1 0.012 15.4 1.1 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-TRAF_2 PF15965.5 PIK61722.1 - 0.29 11.6 17.5 2 9.0 6.4 3.3 1 1 2 3 3 3 0 TRAF-like zinc-finger eIF-3_zeta PF05091.12 PIK61723.1 - 3e-206 686.4 6.9 3.4e-206 686.3 6.9 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 PIK61723.1 - 0.00029 20.4 0.0 0.00081 19.0 0.0 1.8 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus Colicin-DNase PF12639.7 PIK61723.1 - 0.79 10.6 0.1 0.79 10.6 0.1 2.8 1 1 1 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin DUF4298 PF14131.6 PIK61723.1 - 1.4 9.0 5.5 2.6 8.1 1.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) EGF PF00008.27 PIK61724.1 - 6.1e-204 659.4 447.5 2.8e-09 37.1 4.3 32.5 32 0 0 32 32 32 32 EGF-like domain hEGF PF12661.7 PIK61724.1 - 3.7e-117 379.5 387.6 2.2e-07 31.3 3.9 34.6 33 1 0 33 33 33 31 Human growth factor-like EGF EGF_CA PF07645.15 PIK61724.1 - 1e-58 195.3 458.5 9.7e-09 35.3 5.7 32.5 16 9 16 32 32 32 23 Calcium-binding EGF domain EGF_2 PF07974.13 PIK61724.1 - 2.8e-36 123.5 506.7 0.00028 21.2 2.1 32.4 31 1 1 32 32 32 26 EGF-like domain EGF_3 PF12947.7 PIK61724.1 - 4.9e-23 81.0 402.2 0.00058 20.0 8.3 32.6 27 5 5 32 32 32 19 EGF domain CUB PF00431.20 PIK61724.1 - 2e-16 60.3 0.0 4.2e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 CUB domain cEGF PF12662.7 PIK61724.1 - 0.0026 17.6 0.3 0.0026 17.6 0.3 32.0 32 2 0 32 32 32 14 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK61724.1 - 0.07 13.4 390.2 0.25 11.7 6.3 31.9 13 11 18 31 31 31 0 Coagulation Factor Xa inhibitory site p450 PF00067.22 PIK61725.1 - 7.5e-116 387.6 0.0 8.5e-116 387.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UDPG_MGDP_dh PF00984.19 PIK61725.1 - 0.081 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sulfotransfer_2 PF03567.14 PIK61726.1 - 6.2e-10 39.4 1.7 6.2e-10 39.4 1.7 1.5 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK61726.1 - 4.4e-07 29.7 0.4 7.4e-07 28.9 0.4 1.5 1 0 0 1 1 1 1 Sulfotransferase domain Fer4_23 PF18009.1 PIK61726.1 - 0.073 13.5 0.6 0.19 12.1 0.4 1.9 1 1 0 1 1 1 0 4Fe-4S iron-sulfur cluster binding domain CCDC154 PF15450.6 PIK61727.1 - 8e-36 123.7 99.0 4.5e-32 111.3 82.0 4.0 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 154 Vac_Fusion PF02346.16 PIK61727.1 - 0.63 9.7 7.1 0.093 12.4 0.7 3.1 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DASH_Dam1 PF08653.10 PIK61727.1 - 1.5 8.6 9.0 77 3.2 0.1 5.5 6 0 0 6 6 6 0 DASH complex subunit Dam1 PHF5 PF03660.14 PIK61728.1 - 3.5e-41 139.6 11.4 4.3e-41 139.3 11.4 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 PIK61728.1 - 0.023 12.6 7.3 0.023 12.6 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 PIK61728.1 - 1.9 8.6 14.6 1.3 9.1 2.0 2.8 1 1 1 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 PIK61728.1 - 2.5 8.5 16.9 0.14 12.5 2.7 2.6 1 1 1 2 2 2 0 C1 domain DEAD PF00270.29 PIK61729.1 - 4.8e-36 124.1 0.2 6.5e-33 113.9 0.2 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK61729.1 - 5.1e-11 42.9 0.1 2.1e-10 40.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain IDO PF01231.18 PIK61730.1 - 4.2e-24 85.1 1.3 2e-22 79.6 1.3 2.0 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase IDO PF01231.18 PIK61731.1 - 2.3e-33 115.6 0.2 3.1e-33 115.2 0.2 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase CAML PF14963.6 PIK61732.1 - 0.47 10.5 2.0 1.2 9.2 1.9 1.8 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand HEAT_2 PF13646.6 PIK61734.1 - 1.4e-08 35.0 5.0 4.7e-05 23.7 2.5 2.4 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 PIK61734.1 - 0.0023 18.0 7.2 0.41 11.0 0.1 3.7 5 1 0 5 5 5 2 HEAT repeat Chromo PF00385.24 PIK61735.1 - 3.5e-12 46.0 0.6 6.1e-12 45.3 0.6 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Exo_endo_phos_2 PF14529.6 PIK61736.1 - 9.2e-15 54.5 0.0 1.3e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Neurexophilin PF06312.12 PIK61736.1 - 4e-07 29.7 0.0 5.9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Exo_endo_phos PF03372.23 PIK61736.1 - 0.054 13.0 1.6 0.085 12.4 1.5 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF5018 PF16410.5 PIK61736.1 - 0.091 11.4 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) MULE PF10551.9 PIK61738.1 - 2.2e-07 31.2 0.0 5.1e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 PIK61738.1 - 0.038 13.7 0.6 0.063 13.0 0.6 1.3 1 0 0 1 1 1 0 Transposase CGI-121 PF08617.10 PIK61738.1 - 0.098 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Kinase binding protein CGI-121 Fibrinogen_C PF00147.18 PIK61740.1 - 1.2e-63 214.9 3.2 1.4e-63 214.7 3.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61741.1 - 6e-19 68.7 0.3 6.7e-19 68.6 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain LRR_8 PF13855.6 PIK61742.1 - 1.3e-26 92.1 20.0 1.7e-15 56.5 4.5 3.2 3 1 0 3 3 3 2 Leucine rich repeat LRR_5 PF13306.6 PIK61742.1 - 5.9e-14 52.1 2.5 1.4e-13 50.9 2.5 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK61742.1 - 1.7e-12 47.4 25.7 4.9e-05 23.6 0.6 4.2 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK61742.1 - 3e-06 26.9 4.5 3.7e-05 23.3 1.4 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK61742.1 - 0.00011 22.3 17.8 2.2 9.2 0.0 7.0 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK61742.1 - 0.022 14.8 16.1 0.082 13.0 0.1 5.2 6 0 0 6 6 6 0 Leucine Rich repeat zf-CCHC PF00098.23 PIK61743.1 - 1.4e-09 37.5 14.9 0.00018 21.4 1.2 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 PIK61743.1 - 0.0081 16.0 2.2 0.0081 16.0 2.2 3.5 3 1 1 4 4 4 2 Zinc knuckle Ribosomal_L40e PF01020.17 PIK61743.1 - 4 7.4 12.6 1 9.3 8.2 2.1 1 1 1 2 2 2 0 Ribosomal L40e family Fibrinogen_C PF00147.18 PIK61744.1 - 8.5e-36 123.8 3.6 1e-35 123.6 3.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK61744.1 - 0.0053 17.0 11.5 0.0053 17.0 11.5 2.2 1 1 1 2 2 2 1 Trypsin Inhibitor like cysteine rich domain LRR_8 PF13855.6 PIK61745.1 - 1.3e-27 95.3 17.6 1e-15 57.2 6.0 2.9 2 1 0 2 2 2 2 Leucine rich repeat TIR PF01582.20 PIK61745.1 - 1.5e-19 70.5 1.4 2.5e-19 69.8 1.4 1.4 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK61745.1 - 1.7e-15 57.6 0.2 3.2e-15 56.8 0.2 1.4 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.6 PIK61745.1 - 7.2e-14 51.9 2.4 1.6e-13 50.7 2.4 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 PIK61745.1 - 1e-12 48.0 21.6 7.7e-05 23.0 0.5 4.0 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK61745.1 - 1.8e-06 27.5 4.7 1.7e-05 24.4 1.6 2.3 1 1 1 2 2 2 2 Leucine-rich repeat DUF1863 PF08937.11 PIK61745.1 - 6.1e-06 26.6 2.0 6.1e-06 26.6 2.0 2.6 2 1 0 2 2 2 1 MTH538 TIR-like domain (DUF1863) LRR_1 PF00560.33 PIK61745.1 - 0.012 16.0 19.3 16 6.5 0.2 6.9 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK61745.1 - 0.013 15.5 12.9 0.48 10.6 0.3 4.9 4 0 0 4 4 4 0 Leucine Rich repeat DUF5014 PF16406.5 PIK61746.1 - 0.035 14.4 0.5 0.059 13.6 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5014) Fibrinogen_C PF00147.18 PIK61749.1 - 3.8e-40 138.1 17.4 1.3e-39 136.3 17.4 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK61749.1 - 1.2e-06 28.3 15.7 1.2e-06 28.3 15.7 4.2 2 2 1 3 3 3 1 TILa domain TIL PF01826.17 PIK61749.1 - 0.002 18.3 7.5 0.002 18.3 7.5 4.6 3 2 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_MSP1_1 PF12946.7 PIK61749.1 - 0.021 14.9 9.3 0.021 14.9 9.3 3.8 4 0 0 4 4 4 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK61750.1 - 2.7e-38 132.0 16.8 6e-38 130.8 16.8 1.5 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61751.1 - 1.1e-24 87.5 0.5 1.2e-24 87.3 0.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIR PF01582.20 PIK61752.1 - 1.4e-19 70.6 1.0 1.7e-19 70.3 1.0 1.1 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 PIK61752.1 - 7.5e-13 49.1 0.1 9.4e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 PIK61752.1 - 7.9e-07 29.4 0.3 1.2e-06 28.9 0.3 1.2 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Fibrinogen_C PF00147.18 PIK61753.1 - 3.2e-42 144.8 16.7 5.2e-42 144.1 16.7 1.3 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61754.1 - 1.5e-33 116.5 13.7 3e-32 112.2 13.7 2.0 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61756.1 - 1.2e-61 208.3 4.7 1.4e-61 208.1 4.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain RVT_1 PF00078.27 PIK61757.1 - 0.024 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK61758.1 - 4.8e-05 23.3 0.0 0.00015 21.7 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 PIK61758.1 - 0.00019 21.2 0.1 0.00036 20.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH PF17917.1 PIK61758.1 - 0.00024 21.4 0.0 0.00059 20.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 PIK61758.1 - 0.0088 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 RNase H SPC22 PF04573.12 PIK61760.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Signal peptidase subunit zf-CCHC PF00098.23 PIK61761.1 - 1.5e-07 31.2 15.8 0.00045 20.2 0.2 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 PIK61761.1 - 0.0099 15.6 11.3 3.4 7.5 0.4 3.5 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 PIK61761.1 - 0.014 15.3 16.3 0.17 11.8 1.3 3.8 2 1 2 4 4 4 0 Zinc knuckle zf-CCHC_2 PF13696.6 PIK61761.1 - 0.015 15.1 0.2 0.015 15.1 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK61761.1 - 0.015 15.0 0.8 0.015 15.0 0.8 2.7 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_6 PF15288.6 PIK61761.1 - 0.056 13.3 16.3 0.067 13.0 3.8 3.3 4 0 0 4 4 4 0 Zinc knuckle RVT_1 PF00078.27 PIK61762.1 - 1.7e-05 24.5 0.0 2.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPR_MLP1_2 PF07926.12 PIK61764.1 - 0.0014 18.7 2.5 0.0019 18.3 1.8 1.6 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein TSC22 PF01166.18 PIK61764.1 - 0.0054 17.0 1.3 0.011 16.0 1.3 1.5 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF3450 PF11932.8 PIK61764.1 - 0.007 15.7 0.3 0.0098 15.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) EzrA PF06160.12 PIK61764.1 - 0.0083 14.4 0.1 0.011 14.0 0.1 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Nnf1 PF03980.14 PIK61764.1 - 0.013 15.9 0.2 0.024 15.0 0.2 1.5 1 0 0 1 1 1 0 Nnf1 Wtap PF17098.5 PIK61764.1 - 0.028 14.4 0.1 0.039 13.9 0.1 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family Pox_A_type_inc PF04508.12 PIK61764.1 - 0.035 14.0 0.8 0.035 14.0 0.8 1.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Tropomyosin PF00261.20 PIK61764.1 - 0.04 13.3 0.5 0.051 12.9 0.5 1.1 1 0 0 1 1 1 0 Tropomyosin Spc7 PF08317.11 PIK61764.1 - 0.065 12.1 0.9 0.087 11.7 0.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 PIK61764.1 - 0.09 13.1 0.6 0.15 12.3 0.6 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Chibby PF14645.6 PIK61764.1 - 0.12 12.8 0.2 0.17 12.3 0.2 1.4 1 0 0 1 1 1 0 Chibby family DivIC PF04977.15 PIK61764.1 - 0.16 11.8 1.7 0.38 10.5 1.7 1.7 1 1 0 1 1 1 0 Septum formation initiator IFT57 PF10498.9 PIK61765.1 - 0.036 13.0 2.6 0.062 12.3 2.6 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1351 PF07083.11 PIK61765.1 - 0.059 13.1 4.5 0.33 10.7 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) Fib_alpha PF08702.10 PIK61765.1 - 0.06 13.5 0.8 0.11 12.7 0.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Terminase_6C PF17289.2 PIK61765.1 - 0.1 12.7 0.6 0.54 10.3 0.2 2.4 2 1 0 2 2 2 0 Terminase RNaseH-like domain Prefoldin PF02996.17 PIK61765.1 - 0.13 12.2 2.0 0.25 11.3 1.4 1.8 1 1 0 1 1 1 0 Prefoldin subunit DUF2913 PF11140.8 PIK61765.1 - 0.53 10.0 2.9 1.6 8.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) TFIID_30kDa PF03540.13 PIK61766.1 - 3e-26 91.1 0.0 4.9e-26 90.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 PIK61766.1 - 0.0014 18.6 0.0 0.022 14.8 0.0 2.2 1 1 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 PIK61766.1 - 0.1 12.9 0.0 6 7.2 0.0 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HTH_42 PF06224.12 PIK61766.1 - 0.1 12.1 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain TAF PF02969.17 PIK61766.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) PAN_1 PF00024.26 PIK61767.1 - 0.00029 20.7 0.6 0.00029 20.7 0.6 3.0 2 1 0 2 2 2 1 PAN domain PAN_4 PF14295.6 PIK61767.1 - 0.0031 17.4 1.4 0.0089 15.9 0.2 2.1 2 0 0 2 2 2 1 PAN domain PAN_2 PF08276.11 PIK61767.1 - 0.011 15.8 0.3 0.011 15.8 0.3 2.3 2 1 0 2 2 2 0 PAN-like domain Lectin_C PF00059.21 PIK61767.1 - 0.13 13.1 0.1 0.13 13.1 0.1 2.6 3 1 0 3 3 3 0 Lectin C-type domain CRM1_C PF08767.11 PIK61768.1 - 0.024 13.8 2.2 0.062 12.5 2.2 1.6 1 0 0 1 1 1 0 CRM1 C terminal RRM_1 PF00076.22 PIK61769.1 - 9.4e-40 134.3 0.0 2.6e-20 72.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 PIK61769.1 - 0.00067 19.7 0.0 0.43 10.7 0.0 2.6 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 PIK61769.1 - 0.0031 17.5 0.0 0.059 13.4 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 PIK61769.1 - 0.026 14.4 0.0 0.21 11.5 0.0 2.3 2 1 0 2 2 2 0 Occluded RNA-recognition motif Stm1_N PF09598.10 PIK61769.1 - 1.3 10.0 3.6 5 8.0 3.6 2.0 1 1 0 1 1 1 0 Stm1 RRM_1 PF00076.22 PIK61770.1 - 1.7e-05 24.5 0.0 4.9e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prominin PF05478.11 PIK61771.1 - 5e-67 226.5 0.0 6.7e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Prominin DUF948 PF06103.11 PIK61771.1 - 0.011 15.9 4.5 0.075 13.3 0.3 3.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Phage_holin_3_6 PF07332.11 PIK61771.1 - 0.046 13.8 0.0 0.046 13.8 0.0 2.9 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III PMT_4TMC PF16192.5 PIK61771.1 - 0.29 10.7 3.4 1 8.9 0.1 2.5 3 0 0 3 3 3 0 C-terminal four TMM region of protein-O-mannosyltransferase MbeD_MobD PF04899.12 PIK61772.1 - 0.14 12.3 0.2 0.14 12.3 0.2 2.1 3 0 0 3 3 3 0 MbeD/MobD like Fibrinogen_C PF00147.18 PIK61773.1 - 3.1e-11 43.5 3.2 3.6e-11 43.3 3.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61774.1 - 3.2e-33 115.4 0.3 4.2e-33 115.0 0.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61775.1 - 5.5e-38 131.0 0.9 6.4e-38 130.8 0.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 PIK61776.1 - 8.2e-33 114.1 1.6 9.3e-33 113.9 1.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain WWE PF02825.20 PIK61777.1 - 3.9e-18 65.8 0.2 1.2e-17 64.3 0.2 1.9 1 0 0 1 1 1 1 WWE domain RIX1 PF08167.12 PIK61777.1 - 0.17 11.6 6.4 1.6 8.5 0.3 3.5 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis DEAD PF00270.29 PIK61778.1 - 5.5e-44 150.0 0.2 8.9e-44 149.3 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK61778.1 - 3.2e-31 107.9 0.1 1.3e-30 106.0 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK61778.1 - 1.7e-06 28.2 0.0 2.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 PIK61778.1 - 0.0033 16.8 0.5 0.01 15.2 0.0 1.8 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 PIK61778.1 - 0.0043 17.4 0.3 0.0081 16.5 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 PIK61778.1 - 0.0049 16.6 0.0 0.0079 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 PIK61778.1 - 0.088 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Helicase Myosin_head PF00063.21 PIK61779.1 - 1e-193 645.3 4.8 1e-193 645.3 4.8 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) Ank_2 PF12796.7 PIK61779.1 - 2e-26 92.4 1.4 6.3e-13 49.1 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 PIK61779.1 - 7.8e-26 89.8 7.2 3.2e-09 36.9 0.4 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK61779.1 - 3e-23 81.9 0.6 7.5e-11 42.3 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK61779.1 - 1.5e-21 75.8 5.7 6.3e-06 26.4 0.1 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 PIK61779.1 - 1.8e-20 70.8 1.3 4.1e-05 23.6 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat AAA_22 PF13401.6 PIK61779.1 - 0.00065 20.0 0.8 0.007 16.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 PIK61779.1 - 0.0042 17.5 0.2 0.02 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain IQ PF00612.27 PIK61779.1 - 0.014 15.1 0.6 0.034 13.9 0.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif AAA_19 PF13245.6 PIK61779.1 - 0.031 14.6 0.0 0.57 10.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 PIK61779.1 - 0.084 13.3 0.0 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DNA_pol3_delta2 PF13177.6 PIK61779.1 - 0.17 11.6 2.8 0.18 11.6 0.2 2.3 2 0 0 2 2 2 0 DNA polymerase III, delta subunit CSRNP_N PF16019.5 PIK61780.1 - 0.72 9.7 7.0 1.2 9.0 7.0 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus GSHPx PF00255.19 PIK61781.1 - 2.2e-07 30.4 0.0 3.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase DUF4174 PF13778.6 PIK61781.1 - 0.092 13.2 0.0 0.1 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) PhdYeFM_antitox PF02604.19 PIK61781.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system Epimerase PF01370.21 PIK61782.1 - 0.0035 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 PIK61783.1 - 9.2e-21 74.2 3.4 1.3e-20 73.8 3.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK61783.1 - 9.1e-10 38.0 11.2 9.1e-10 38.0 11.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sulfotransfer_1 PF00685.27 PIK61784.1 - 2.7e-10 40.2 0.0 8.9e-10 38.5 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK61784.1 - 4.6e-10 40.2 0.1 6.6e-08 33.2 0.0 2.4 2 1 0 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK61784.1 - 0.028 14.3 0.4 0.05 13.5 0.0 1.6 2 0 0 2 2 2 0 Sulfotransferase family PBP PF01161.20 PIK61785.1 - 7.1e-07 29.6 0.2 1.1e-06 29.0 0.2 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF4535 PF15054.6 PIK61786.1 - 3.8e-10 39.3 0.0 6.7e-10 38.6 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4535) TSP_1 PF00090.19 PIK61787.1 - 3.9e-62 206.3 111.1 1.3e-11 44.5 8.7 7.3 7 0 0 7 7 7 7 Thrombospondin type 1 domain fn3 PF00041.21 PIK61787.1 - 0.00017 21.9 4.4 0.71 10.3 0.1 3.6 2 1 0 2 2 2 2 Fibronectin type III domain TIMP PF00965.17 PIK61788.1 - 0.0024 17.7 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Pkinase PF00069.25 PIK61790.1 - 6.1e-41 140.5 0.2 1.2e-40 139.6 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK61790.1 - 1.5e-20 73.6 0.0 2.8e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 PIK61790.1 - 0.00022 20.1 0.1 0.00034 19.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 PIK61790.1 - 0.0012 18.0 0.3 0.002 17.2 0.3 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 PIK61790.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HMMR_C PF15908.5 PIK61791.1 - 5.8e-07 29.9 10.8 5.8e-07 29.9 10.8 3.7 1 1 1 3 3 3 1 Hyaluronan mediated motility receptor C-terminal Spectrin PF00435.21 PIK61791.1 - 0.021 15.3 10.8 0.021 15.3 10.8 3.1 1 1 2 3 3 3 0 Spectrin repeat PRKG1_interact PF15898.5 PIK61791.1 - 0.083 13.8 48.9 0.58 11.1 21.0 3.3 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain HTH_41 PF14502.6 PIK61791.1 - 0.1 12.3 0.3 0.3 10.8 0.3 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain YabA PF06156.13 PIK61791.1 - 0.16 12.6 48.8 0.2 12.3 2.9 4.3 1 1 2 4 4 4 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 PIK61791.1 - 1 9.4 49.9 0.64 10.1 20.1 3.5 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 PIK61791.1 - 1.9 7.3 51.6 0.28 10.0 14.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 PIK61791.1 - 2.6 8.2 34.9 0.038 14.2 13.2 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Kinesin PF00225.23 PIK61792.1 - 5.1e-89 298.5 0.0 5.1e-89 298.5 0.0 2.8 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK61792.1 - 5e-14 52.5 0.0 5e-14 52.5 0.0 3.3 3 0 0 3 3 3 1 Microtubule binding ADIP PF11559.8 PIK61792.1 - 0.003 17.6 10.3 0.003 17.6 10.3 8.4 4 2 3 8 8 8 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 PIK61792.1 - 0.0041 17.4 13.7 0.0041 17.4 13.7 7.4 2 1 5 7 7 7 1 Autophagy protein 16 (ATG16) HTH_Tnp_1 PF01527.20 PIK61792.1 - 0.3 11.4 0.0 0.3 11.4 0.0 4.6 5 0 0 5 5 5 0 Transposase DUF1796 PF08795.10 PIK61792.1 - 0.78 9.7 8.3 0.12 12.3 0.8 3.2 2 1 1 3 3 3 0 Putative papain-like cysteine peptidase (DUF1796) MPP6 PF10175.9 PIK61793.1 - 8.8e-32 110.4 12.5 2.9e-31 108.7 7.3 2.0 2 0 0 2 2 2 2 M-phase phosphoprotein 6 Kinesin PF00225.23 PIK61794.1 - 6.9e-93 311.2 0.0 6.9e-93 311.2 0.0 3.2 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 PIK61794.1 - 1.1e-46 158.5 0.0 1.1e-46 158.5 0.0 2.8 3 0 0 3 3 3 1 Microtubule binding RVT_1 PF00078.27 PIK61796.1 - 1.2e-08 34.8 0.0 1.4e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ParBc PF02195.18 PIK61796.1 - 0.094 13.0 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 ParB-like nuclease domain Phosphodiest PF01663.22 PIK61797.1 - 2.6e-75 254.2 1.5 3e-75 254.0 1.5 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 PIK61797.1 - 0.00011 21.6 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 PIK61797.1 - 0.0003 20.3 0.4 0.13 11.6 0.0 2.3 1 1 1 2 2 2 2 Sulfatase DUF229 PF02995.17 PIK61797.1 - 0.045 12.4 0.0 0.075 11.6 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF229) LCAT PF02450.15 PIK61798.1 - 8.9e-65 219.4 0.0 1.6e-62 212.0 0.0 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 PIK61798.1 - 0.0005 19.6 0.0 0.0008 19.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 PIK61798.1 - 0.0043 16.8 0.1 0.013 15.2 0.0 1.9 2 0 0 2 2 2 1 PGAP1-like protein Esterase PF00756.20 PIK61798.1 - 0.0068 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 PIK61798.1 - 0.012 14.9 0.0 0.024 13.9 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 PIK61798.1 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 PIK61798.1 - 0.057 14.0 0.0 0.079 13.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0029 PF01205.19 PIK61799.1 - 2.8e-29 101.5 0.1 5.4e-29 100.6 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 PIK61799.1 - 7.8e-13 48.7 1.2 1.6e-12 47.7 1.2 1.6 1 0 0 1 1 1 1 RWD domain SRCR PF00530.18 PIK61800.1 - 6e-28 97.3 19.2 8.7e-10 39.0 0.5 4.2 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK61800.1 - 0.00071 20.1 2.5 0.00071 20.1 2.5 3.6 4 0 0 4 4 4 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK61800.1 - 0.017 15.7 7.1 1.1 9.8 0.1 3.1 3 0 0 3 3 3 0 Hepsin, SRCR domain SSXT PF05030.12 PIK61801.1 - 4.6e-26 90.2 1.7 1.3e-25 88.8 1.7 1.8 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Aminotran_3 PF00202.21 PIK61802.1 - 1.1e-83 281.2 0.0 3.6e-83 279.5 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-III Glucosamine_iso PF01182.20 PIK61803.1 - 5.4e-65 219.4 0.0 6.1e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase CENP-L PF13092.6 PIK61805.1 - 5.1e-10 39.8 0.0 6e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 TPT PF03151.16 PIK61806.1 - 2e-17 63.5 21.8 2.6e-17 63.1 21.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF2614 PF11023.8 PIK61806.1 - 0.11 12.6 0.1 0.11 12.6 0.1 3.4 3 1 0 3 3 3 0 Zinc-ribbon containing domain DUF2347 PF09804.9 PIK61807.1 - 8e-10 38.8 0.0 8.7e-10 38.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Sulfotransfer_3 PF13469.6 PIK61808.1 - 0.00041 20.8 0.0 0.00072 20.0 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_3 PF13469.6 PIK61809.1 - 5e-10 40.1 0.4 1.3e-07 32.2 0.1 2.5 1 1 1 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK61809.1 - 1.4e-07 31.3 0.4 2.5e-07 30.4 0.4 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 PIK61809.1 - 0.002 18.0 2.3 0.0045 16.8 0.6 2.3 2 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_1 PF00685.27 PIK61810.1 - 1.8e-06 27.7 0.1 2.6e-06 27.1 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK61810.1 - 2.8e-05 24.6 0.2 0.0061 17.0 0.2 2.9 1 1 0 1 1 1 1 Sulfotransferase family Glyco_transf_90 PF05686.12 PIK61811.1 - 5.5e-30 104.6 0.0 6.2e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_transf_90 PF05686.12 PIK61812.1 - 4.7e-64 216.7 0.4 5.3e-64 216.6 0.4 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 PIK61812.1 - 3.1e-06 27.5 0.1 6.6e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 PPO1_DWL PF12142.8 PIK61812.1 - 0.066 13.0 1.0 0.18 11.6 1.0 1.7 1 0 0 1 1 1 0 Polyphenol oxidase middle domain zf-H2C2_2 PF13465.6 PIK61813.1 - 3.8e-17 61.8 21.0 1.9e-06 28.0 0.5 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK61813.1 - 7e-15 54.6 21.9 5.4e-06 26.6 0.7 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK61813.1 - 9.8e-14 50.9 20.2 8.9e-05 23.0 0.6 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 PIK61813.1 - 4.6e-08 33.2 10.7 0.0012 19.2 0.1 3.6 4 0 0 4 4 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK61813.1 - 6e-08 32.8 11.1 8.1e-05 22.8 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK61813.1 - 2.7e-07 30.4 19.5 0.0011 18.9 1.4 4.5 3 2 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 PIK61813.1 - 1.4e-06 28.5 5.8 0.00055 20.2 1.1 2.4 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 PIK61813.1 - 5.1e-06 26.8 5.8 0.0084 16.6 0.4 3.5 3 1 0 3 3 3 2 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 PIK61813.1 - 0.00039 20.2 9.5 0.2 11.5 0.1 3.4 1 1 1 3 3 3 2 GAGA factor zf-C2H2_2 PF12756.7 PIK61813.1 - 0.0094 16.3 11.8 0.27 11.6 0.3 3.1 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 PIK61813.1 - 0.011 15.4 5.6 0.33 10.6 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Prok-RING_4 PF14447.6 PIK61813.1 - 0.012 15.4 5.2 0.28 11.1 0.3 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 DUF2225 PF09986.9 PIK61813.1 - 0.018 14.8 8.3 0.13 12.0 0.9 2.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) UBZ_FAAP20 PF15750.5 PIK61813.1 - 0.052 13.5 5.0 4.7 7.3 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger CpXC PF14353.6 PIK61813.1 - 0.059 13.4 3.0 4.3 7.4 0.3 2.9 1 1 1 2 2 2 0 CpXC protein zf-MYST PF17772.1 PIK61813.1 - 0.066 12.8 7.7 0.33 10.6 0.1 3.0 3 0 0 3 3 3 0 MYST family zinc finger domain Elf1 PF05129.13 PIK61813.1 - 0.068 13.2 7.0 0.084 12.9 2.0 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_9 PF16293.5 PIK61813.1 - 0.07 13.0 2.8 5.2 7.0 0.0 2.7 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF3268 PF11672.8 PIK61813.1 - 0.12 12.7 2.5 0.22 11.8 2.5 1.4 1 1 0 1 1 1 0 zinc-finger-containing domain zf-C3HC4 PF00097.25 PIK61813.1 - 0.15 11.9 3.5 16 5.4 0.2 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK61813.1 - 0.18 11.8 6.4 5.4 7.1 0.3 3.2 3 0 0 3 3 3 0 zinc-RING finger domain zf-RING_2 PF13639.6 PIK61813.1 - 0.21 11.9 6.0 32 4.9 0.0 3.1 2 1 0 2 2 2 0 Ring finger domain FYVE PF01363.21 PIK61813.1 - 0.27 11.4 13.3 0.76 10.0 0.6 3.0 1 1 1 2 2 2 0 FYVE zinc finger Baculo_IE-1 PF05290.11 PIK61813.1 - 0.29 11.1 2.7 3.9 7.4 0.7 2.3 1 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_aberr PF17017.5 PIK61813.1 - 0.34 11.1 3.5 0.15 12.1 1.0 1.6 1 1 0 1 1 1 0 Aberrant zinc-finger FYVE_2 PF02318.16 PIK61813.1 - 0.41 10.9 4.4 2.5 8.4 0.2 2.2 1 1 1 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.6 PIK61813.1 - 0.44 10.5 4.6 8 6.5 0.1 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Endonuclease_7 PF02945.15 PIK61813.1 - 0.56 10.2 4.0 0.27 11.2 0.7 1.9 1 1 1 2 2 2 0 Recombination endonuclease VII TRAF6_Z2 PF18048.1 PIK61813.1 - 0.67 10.1 6.8 1 9.5 0.3 2.5 2 1 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 C1_4 PF07975.12 PIK61813.1 - 0.68 10.2 5.2 6.7 7.0 1.5 2.6 1 1 2 3 3 3 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 PIK61813.1 - 0.74 9.8 4.5 0.81 9.7 1.2 2.4 1 1 1 2 2 2 0 zinc-ribbons HNH_5 PF14279.6 PIK61813.1 - 0.76 9.7 4.6 7.5 6.5 0.9 2.5 2 1 0 2 2 2 0 HNH endonuclease zf-C2HC_2 PF13913.6 PIK61813.1 - 0.9 9.5 12.5 5.2 7.1 0.7 3.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.6 PIK61813.1 - 1 9.6 4.3 21 5.5 0.1 2.8 3 0 0 3 3 2 0 zinc-ribbon zf-C2H2_11 PF16622.5 PIK61813.1 - 1.1 9.0 12.4 2.3 8.1 2.2 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-WRNIP1_ubi PF18279.1 PIK61813.1 - 1.2 9.9 5.8 55 4.7 0.0 3.3 2 1 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-BED PF02892.15 PIK61813.1 - 4.5 7.4 10.8 27 4.9 1.7 3.3 1 1 0 2 2 2 0 BED zinc finger Ribosomal_L37ae PF01780.19 PIK61813.1 - 4.6 7.4 6.6 12 6.1 1.3 3.0 1 1 1 2 2 2 0 Ribosomal L37ae protein family zf-C2H2_4 PF13894.6 PIK61814.1 - 4.3e-20 70.7 47.7 0.00018 22.0 1.9 7.7 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK61814.1 - 1.4e-16 59.9 42.1 0.0011 19.2 2.0 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK61814.1 - 6.3e-12 45.3 41.1 2.3e-05 24.6 1.2 7.8 8 0 0 8 8 7 4 Zinc-finger double domain zf-met PF12874.7 PIK61814.1 - 7.7e-10 38.8 47.1 0.0017 18.7 0.8 7.8 8 0 0 8 8 7 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK61814.1 - 6e-07 29.3 44.1 0.0076 16.2 0.0 7.5 7 1 0 7 7 7 4 C2H2-type zinc finger zf-Di19 PF05605.12 PIK61814.1 - 0.00048 20.4 16.7 0.0012 19.0 2.6 4.7 2 1 3 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 PIK61814.1 - 0.00062 19.6 24.4 0.14 12.1 0.2 6.0 5 2 2 7 7 7 3 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.8 PIK61814.1 - 0.00066 19.9 44.9 0.084 13.2 0.5 7.3 8 0 0 8 8 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 PIK61814.1 - 0.00074 19.8 42.9 0.3 11.4 7.6 6.5 1 1 5 6 6 6 2 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 PIK61814.1 - 0.005 17.6 24.8 0.97 10.2 7.3 3.8 2 1 1 3 3 3 2 zinc-ribbon family zf_UBZ PF18439.1 PIK61814.1 - 0.0063 16.1 31.1 3.6 7.3 0.2 7.2 7 0 0 7 7 7 2 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 PIK61814.1 - 0.051 13.4 0.2 0.051 13.4 0.2 6.8 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-ribbon_3 PF13248.6 PIK61814.1 - 0.17 11.4 7.8 1.2 8.6 0.0 3.7 4 0 0 4 4 4 0 zinc-ribbon domain zf-LYAR PF08790.11 PIK61814.1 - 0.35 10.8 0.2 0.35 10.8 0.2 6.0 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-trcl PF13451.6 PIK61814.1 - 0.37 10.7 21.9 2.5 8.0 2.5 5.9 5 1 1 6 6 6 0 Probable zinc-ribbon domain zf-C2H2_7 PF15269.6 PIK61814.1 - 0.64 10.1 0.1 0.64 10.1 0.1 4.4 2 2 3 5 5 5 0 Zinc-finger DUF2225 PF09986.9 PIK61814.1 - 0.73 9.5 9.6 4.6 6.9 0.0 3.6 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) HypA PF01155.19 PIK61814.1 - 0.96 9.5 24.6 2.3 8.2 5.5 4.4 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 PIK61814.1 - 1.6 8.9 28.6 4.5 7.5 1.1 5.7 3 2 3 6 6 6 0 Zinc ribbon domain Actin_micro PF17003.5 PIK61814.1 - 2.1 7.4 32.6 0.077 12.2 1.1 5.4 1 1 3 4 4 4 0 Putative actin-like family Elf1 PF05129.13 PIK61814.1 - 7 6.8 27.7 4.4 7.4 0.3 4.9 1 1 3 4 4 3 0 Transcription elongation factor Elf1 like Mut7-C PF01927.16 PIK61814.1 - 9.4 6.3 22.3 1 9.4 3.3 4.1 1 1 3 4 4 4 0 Mut7-C RNAse domain zf-C2H2_4 PF13894.6 PIK61815.1 - 1.4e-22 78.4 87.6 0.0053 17.5 0.9 12.7 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 PIK61815.1 - 2.1e-14 54.3 48.4 0.0001 23.0 7.2 6.7 2 1 4 6 6 6 6 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 PIK61815.1 - 2.5e-12 46.5 91.0 4.8e-05 23.6 0.3 12.6 12 1 0 12 12 12 7 Zinc finger, C2H2 type zf-met PF12874.7 PIK61815.1 - 0.0017 18.7 49.0 0.15 12.5 0.2 9.5 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK61815.1 - 0.0021 18.3 86.3 0.0079 16.5 6.1 10.1 6 2 6 12 12 12 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 PIK61815.1 - 0.003 17.8 40.5 0.0068 16.7 1.9 5.7 3 1 2 5 5 5 3 C2H2-type zinc ribbon zf_Hakai PF18408.1 PIK61815.1 - 0.01 15.5 8.8 0.29 10.9 0.0 4.6 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain DUF4428 PF14471.6 PIK61815.1 - 0.23 11.4 7.1 0.4 10.6 0.7 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) zf-C2H2_11 PF16622.5 PIK61815.1 - 3.8 7.4 0.0 3.8 7.4 0.0 7.9 8 0 0 8 8 8 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 PIK61815.1 - 4 8.3 42.1 8.7 7.2 4.3 7.1 2 1 5 7 7 7 0 zinc-ribbon family zf-C2H2 PF00096.26 PIK61816.1 - 1.9e-14 53.2 45.1 3.9e-05 23.9 1.0 6.6 6 1 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK61816.1 - 3.4e-13 49.2 44.0 0.0087 16.8 0.5 6.9 6 1 1 7 7 7 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK61816.1 - 1.6e-10 40.9 45.5 2.5e-06 27.7 0.7 7.1 7 0 0 7 7 7 3 Zinc-finger double domain zf-met PF12874.7 PIK61816.1 - 1.1e-05 25.7 26.8 0.042 14.3 0.1 6.4 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 PIK61816.1 - 0.0001 22.5 26.3 0.0056 16.9 0.6 4.8 5 0 0 5 5 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 PIK61816.1 - 0.003 17.8 31.4 0.17 12.2 0.1 6.4 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 PIK61816.1 - 0.042 14.0 1.5 0.042 14.0 1.5 4.8 5 0 0 5 5 5 0 Zinc ribbon domain zf_C2H2_10 PF18414.1 PIK61816.1 - 0.091 12.3 2.0 0.93 9.1 0.1 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger zf-C2H2_2 PF12756.7 PIK61816.1 - 0.1 13.0 0.1 0.1 13.0 0.1 5.3 3 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3 PF13878.6 PIK61816.1 - 0.11 12.3 0.5 0.11 12.3 0.5 3.1 2 1 1 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-HIT PF04438.16 PIK61816.1 - 0.15 11.9 0.2 0.15 11.9 0.2 3.8 4 0 0 4 4 4 0 HIT zinc finger Mu-like_Com PF10122.9 PIK61816.1 - 0.21 11.1 3.0 32 4.1 0.1 3.6 3 0 0 3 3 3 0 Mu-like prophage protein Com zf_UBZ PF18439.1 PIK61816.1 - 0.44 10.2 15.5 1.2 8.8 0.1 4.8 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger PyrI_C PF02748.15 PIK61816.1 - 0.68 9.9 5.4 16 5.5 0.1 3.7 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HypA PF01155.19 PIK61816.1 - 0.84 9.7 8.2 0.2 11.7 0.7 3.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ARS2 PF04959.13 PIK61816.1 - 1.6 9.1 5.3 13 6.1 0.2 3.2 2 1 2 4 4 4 0 Arsenite-resistance protein 2 DUF2072 PF09845.9 PIK61816.1 - 1.8 8.8 7.4 2.4 8.4 0.1 3.3 2 1 1 3 3 3 0 Zn-ribbon containing protein Zn_ribbon_SprT PF17283.2 PIK61816.1 - 3.4 7.6 14.1 0.053 13.4 4.4 2.9 3 0 0 3 3 3 0 SprT-like zinc ribbon domain FlhC PF05280.11 PIK61816.1 - 5.3 6.7 6.4 2.2 8.0 0.7 2.5 1 1 1 2 2 2 0 Flagellar transcriptional activator (FlhC) zf-C2H2_9 PF16293.5 PIK61816.1 - 5.9 6.8 11.8 5.8 6.8 0.3 4.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-Sec23_Sec24 PF04810.15 PIK61816.1 - 6.4 6.9 13.8 39 4.4 0.0 4.8 5 0 0 5 5 4 0 Sec23/Sec24 zinc finger CIAPIN1 PF05093.13 PIK61817.1 - 4.7e-22 78.4 17.1 2.2e-18 66.6 2.9 3.4 3 1 1 4 4 4 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.12 PIK61817.1 - 0.0013 19.3 0.0 0.0035 18.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK61817.1 - 0.014 16.1 0.0 0.036 14.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Cystatin PF00031.21 PIK61817.1 - 0.019 15.2 0.2 0.047 14.0 0.2 1.6 1 0 0 1 1 1 0 Cystatin domain Methyltransf_29 PF03141.16 PIK61817.1 - 0.15 10.6 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Inositol_P PF00459.25 PIK61818.1 - 8e-77 258.4 0.0 9.3e-77 258.2 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family F5_F8_type_C PF00754.25 PIK61819.1 - 3.3e-22 79.0 0.0 6.6e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain AAA PF00004.29 PIK61821.1 - 5.6e-32 110.9 0.0 1.1e-31 110.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK61821.1 - 9.6e-07 29.2 0.9 4.8e-06 26.9 0.2 2.4 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 PIK61821.1 - 1.5e-06 28.8 0.1 9.8e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 PIK61821.1 - 4.5e-05 24.0 0.0 0.00011 22.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 PIK61821.1 - 0.00013 22.0 0.0 0.00026 21.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 PIK61821.1 - 0.00014 21.8 0.3 0.00046 20.2 0.3 1.8 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 PIK61821.1 - 0.00022 21.4 0.0 0.00043 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 PIK61821.1 - 0.0014 18.4 0.0 0.0058 16.4 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 PIK61821.1 - 0.0017 18.7 0.0 0.0042 17.5 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 PIK61821.1 - 0.0019 17.8 0.4 0.23 11.0 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 PIK61821.1 - 0.0019 17.9 0.0 0.0048 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 PIK61821.1 - 0.002 17.9 0.1 0.0061 16.3 0.0 1.9 2 1 0 2 2 2 1 Cytidylate kinase TsaE PF02367.17 PIK61821.1 - 0.0023 17.9 0.0 0.0062 16.5 0.0 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 PIK61821.1 - 0.0026 17.9 0.0 0.0082 16.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.6 PIK61821.1 - 0.0029 17.3 0.0 0.0085 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK61821.1 - 0.0038 17.2 0.1 0.01 15.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 PIK61821.1 - 0.0039 17.0 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 PIK61821.1 - 0.0042 17.3 0.0 0.0094 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 PIK61821.1 - 0.0059 16.8 0.0 4.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 PIK61821.1 - 0.0073 15.5 0.1 0.068 12.3 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 PIK61821.1 - 0.0079 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 PIK61821.1 - 0.0081 15.9 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 PIK61821.1 - 0.0089 15.3 0.0 0.017 14.3 0.0 1.5 2 0 0 2 2 1 1 TIP49 P-loop domain AAA_7 PF12775.7 PIK61821.1 - 0.009 15.5 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 PIK61821.1 - 0.01 15.7 1.2 3.3 7.5 0.0 2.6 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 PIK61821.1 - 0.012 16.1 0.0 0.037 14.5 0.0 1.9 2 0 0 2 2 1 0 ABC transporter AAA_17 PF13207.6 PIK61821.1 - 0.014 15.8 0.0 0.041 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK61821.1 - 0.02 15.3 0.0 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 PIK61821.1 - 0.023 13.9 0.1 7.5 5.7 0.0 2.4 1 1 1 2 2 2 0 KAP family P-loop domain ATPase PF06745.13 PIK61821.1 - 0.029 13.7 0.1 0.8 9.0 0.0 2.3 1 1 0 2 2 2 0 KaiC Rad17 PF03215.15 PIK61821.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Sigma54_activat PF00158.26 PIK61821.1 - 0.032 13.9 0.0 0.32 10.7 0.0 2.5 3 0 0 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 PIK61821.1 - 0.034 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 PIK61821.1 - 0.039 13.7 0.0 0.095 12.4 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 PIK61821.1 - 0.046 13.2 0.0 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.11 PIK61821.1 - 0.049 13.5 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 PIK61821.1 - 0.065 13.4 0.0 0.34 11.0 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF2075 PF09848.9 PIK61821.1 - 0.098 11.9 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.23 PIK61821.1 - 0.12 12.5 0.1 1.5 8.9 0.0 2.5 3 0 0 3 3 2 0 50S ribosome-binding GTPase DUF3512 PF12024.8 PIK61822.1 - 1.3e-41 142.7 3.1 2.6e-26 92.5 0.2 4.3 4 1 0 4 4 4 2 Domain of unknown function (DUF3512) Bromodomain PF00439.25 PIK61822.1 - 4.9e-18 65.0 0.5 1e-17 64.0 0.5 1.5 1 0 0 1 1 1 1 Bromodomain DNA_Packaging_2 PF11123.8 PIK61822.1 - 0.0059 16.8 0.1 5.2 7.4 0.0 2.7 2 0 0 2 2 2 2 DNA packaging protein Lin-8 PF03353.15 PIK61822.1 - 1.9 8.0 12.5 0.03 13.9 2.5 2.5 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist Avidin PF01382.17 PIK61823.1 - 2.2e-27 95.8 3.5 2.9e-27 95.4 3.5 1.1 1 0 0 1 1 1 1 Avidin family TMEM52 PF14979.6 PIK61824.1 - 3.1 7.7 7.6 1.2e+02 2.5 7.6 2.4 1 1 0 1 1 1 0 Transmembrane 52 AA_permease_2 PF13520.6 PIK61826.1 - 1.2e-27 96.8 28.5 5.3e-27 94.7 28.5 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 PIK61826.1 - 7.6e-17 61.1 9.8 7.6e-17 61.1 9.8 2.0 2 0 0 2 2 2 1 Amino acid permease PKD_channel PF08016.12 PIK61826.1 - 0.0046 15.7 5.0 0.0067 15.2 5.0 1.2 1 0 0 1 1 1 1 Polycystin cation channel AA_permease_2 PF13520.6 PIK61827.1 - 6.4e-11 41.7 1.6 6.6e-11 41.7 1.6 1.0 1 0 0 1 1 1 1 Amino acid permease Solute_trans_a PF03619.16 PIK61828.1 - 3.3e-45 154.7 14.3 3.2e-42 144.9 2.3 3.0 1 1 2 3 3 3 2 Organic solute transporter Ostalpha NPL PF17800.1 PIK61829.1 - 9e-17 61.6 0.7 3.1e-16 59.8 0.0 2.2 3 0 0 3 3 3 1 Nucleoplasmin-like domain zf-H2C2_2 PF13465.6 PIK61829.1 - 1.4e-05 25.3 22.6 0.14 12.6 0.8 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK61829.1 - 0.00011 22.7 34.7 0.067 14.1 7.6 5.3 5 0 0 5 5 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK61829.1 - 0.0029 18.0 8.7 0.0029 18.0 8.7 4.9 5 0 0 5 5 4 2 Zinc finger, C2H2 type Mut7-C PF01927.16 PIK61829.1 - 0.067 13.3 15.3 0.038 14.1 4.5 3.1 1 1 2 3 3 3 0 Mut7-C RNAse domain zf-C2H2_jaz PF12171.8 PIK61829.1 - 0.11 12.8 28.9 1.6 9.1 2.3 4.8 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.21 PIK61829.1 - 0.25 11.5 17.3 1.2 9.3 6.1 3.0 2 1 0 2 2 2 0 FYVE zinc finger CpXC PF14353.6 PIK61829.1 - 0.52 10.4 7.1 0.34 11.0 0.3 2.7 1 1 1 2 2 2 0 CpXC protein zf-C2H2_6 PF13912.6 PIK61829.1 - 1.1 9.3 23.5 6.1 7.0 4.3 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf-MYST PF17772.1 PIK61829.1 - 1.6 8.4 7.2 0.58 9.8 1.3 2.5 1 1 1 2 2 2 0 MYST family zinc finger domain zf-C2H2_3rep PF18868.1 PIK61829.1 - 1.7 9.3 19.0 7.5 7.2 1.8 4.3 2 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats Elf1 PF05129.13 PIK61829.1 - 6.9 6.8 16.7 0.93 9.6 0.1 3.7 2 1 2 4 4 4 0 Transcription elongation factor Elf1 like zf-C2H2_4 PF13894.6 PIK61830.1 - 8.9e-05 23.0 25.9 0.073 14.0 2.4 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK61830.1 - 0.00016 21.9 26.5 0.026 14.9 2.4 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 PIK61830.1 - 0.0042 17.3 18.1 0.059 13.7 3.6 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK61830.1 - 0.013 15.9 16.5 0.16 12.4 0.6 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 PIK61830.1 - 0.037 14.5 3.2 0.037 14.5 3.2 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 PIK61830.1 - 0.44 10.9 11.0 0.2 11.9 4.0 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 PIK61830.1 - 0.6 10.1 9.8 3.5 7.6 0.2 3.1 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FYVE PF01363.21 PIK61830.1 - 2.6 8.3 17.8 13 6.0 17.8 2.0 1 1 0 1 1 1 0 FYVE zinc finger zf-AN1 PF01428.16 PIK61830.1 - 4.1 7.7 21.9 4 7.7 1.1 3.2 2 1 1 3 3 3 0 AN1-like Zinc finger DUF2024 PF09630.10 PIK61830.1 - 6.9 6.6 7.7 5.2 7.0 2.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2024) zf-C2H2_jaz PF12171.8 PIK61831.1 - 8.7e-12 45.0 20.8 0.0054 17.0 1.2 4.4 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK61831.1 - 2.6e-10 40.2 40.0 0.0014 19.3 1.3 4.6 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK61831.1 - 6.9e-10 38.8 36.0 0.00012 22.4 2.0 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 PIK61831.1 - 4.5e-09 36.3 39.7 0.0078 16.6 6.3 5.2 4 1 1 5 5 5 4 Zinc-finger double domain zf-C2HC_2 PF13913.6 PIK61831.1 - 1.3e-05 24.9 25.3 0.028 14.3 0.9 4.6 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK61831.1 - 2.7e-05 23.8 15.4 0.16 11.7 1.3 4.2 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2HE PF16278.5 PIK61831.1 - 4.5e-05 23.8 22.8 0.091 13.2 0.6 4.4 2 1 1 4 4 4 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_8 PF15909.5 PIK61831.1 - 0.0004 20.6 4.3 0.0004 20.6 4.3 2.2 1 1 1 2 2 2 1 C2H2-type zinc ribbon DUF3268 PF11672.8 PIK61831.1 - 0.0052 17.1 5.2 0.85 10.0 0.2 2.2 2 0 0 2 2 2 2 zinc-finger-containing domain zf-AN1 PF01428.16 PIK61831.1 - 0.0056 16.8 26.8 0.83 9.9 0.2 4.4 3 1 1 4 4 4 2 AN1-like Zinc finger BHD_1 PF10403.9 PIK61831.1 - 0.027 14.3 0.3 0.052 13.4 0.1 1.7 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 1 Diedel PF13164.6 PIK61831.1 - 0.035 14.5 3.9 0.035 14.5 3.9 1.9 2 1 0 2 2 1 0 Diedel PyrI_C PF02748.15 PIK61831.1 - 0.045 13.7 14.2 2.9 7.8 0.3 4.2 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_C2H2_ZHX PF18387.1 PIK61831.1 - 0.12 12.1 0.4 0.12 12.1 0.4 3.8 3 2 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 PIK61831.1 - 0.25 11.4 22.2 2 8.5 4.9 4.4 2 1 2 4 4 4 0 BED zinc finger XPA_N PF01286.18 PIK61831.1 - 0.3 11.2 11.8 5.5 7.1 0.1 4.2 4 0 0 4 4 4 0 XPA protein N-terminal zf-trcl PF13451.6 PIK61831.1 - 0.58 10.1 13.4 4.4 7.3 4.4 3.6 3 1 0 3 3 3 0 Probable zinc-ribbon domain zf-CHCC PF10276.9 PIK61831.1 - 1.2 9.3 17.4 0.48 10.5 1.0 3.8 4 0 0 4 4 4 0 Zinc-finger domain LIM PF00412.22 PIK61831.1 - 1.7 9.0 19.3 1.6 9.0 6.1 3.6 2 2 0 2 2 2 0 LIM domain zf-C2H2_2 PF12756.7 PIK61831.1 - 1.9 8.9 23.8 1.9 8.9 0.3 4.1 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) FYDLN_acid PF09538.10 PIK61831.1 - 2.4 8.9 6.0 28 5.5 0.1 3.4 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) HalOD2 PF18547.1 PIK61831.1 - 2.8 7.9 9.1 75 3.3 0.1 4.0 4 0 0 4 4 4 0 Halobacterial output domain 2 HMA PF00403.26 PIK61832.1 - 4.6e-36 123.1 8.1 2.2e-13 50.4 0.0 3.2 3 0 0 3 3 3 3 Heavy-metal-associated domain RRM_3 PF08777.11 PIK61832.1 - 5.7e-05 23.1 1.9 0.024 14.7 0.0 3.0 2 1 1 3 3 3 1 RNA binding motif DUF2200 PF09966.9 PIK61832.1 - 0.0029 17.7 3.6 0.26 11.5 0.1 3.2 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2200) Poly_export PF02563.16 PIK61832.1 - 0.0034 17.6 0.1 9.1 6.6 0.0 3.3 3 0 0 3 3 3 1 Polysaccharide biosynthesis/export protein DUF2997 PF11211.8 PIK61832.1 - 0.006 16.3 3.6 13 5.6 0.1 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2997) Fer2_BFD PF04324.15 PIK61832.1 - 0.038 14.3 4.7 16 5.9 0.1 4.1 4 0 0 4 4 4 0 BFD-like [2Fe-2S] binding domain TusA PF01206.17 PIK61832.1 - 0.14 12.0 1.0 2.9 7.8 0.2 3.0 2 1 0 2 2 2 0 Sulfurtransferase TusA Atg14 PF10186.9 PIK61832.1 - 1.5 7.8 8.8 0.62 9.1 0.2 3.0 2 1 2 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 Hydrolase PF00702.26 PIK61833.1 - 2.9e-50 171.5 2.0 9.9e-50 169.7 1.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 PIK61833.1 - 2.9e-48 163.8 0.6 2.9e-48 163.8 0.6 2.4 3 0 0 3 3 3 1 E1-E2 ATPase HMA PF00403.26 PIK61833.1 - 1.6e-39 134.2 6.1 6.7e-13 48.9 1.2 4.0 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 PIK61833.1 - 1.1e-06 28.6 3.8 0.00032 20.5 0.7 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 PIK61833.1 - 0.0074 16.4 0.1 0.025 14.7 0.1 2.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 PIK61833.1 - 0.033 14.6 0.0 0.094 13.1 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4059 PF13268.6 PIK61833.1 - 0.07 13.5 0.4 0.34 11.4 0.4 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) RRM_3 PF08777.11 PIK61833.1 - 0.081 13.0 0.1 0.23 11.5 0.1 1.8 1 0 0 1 1 1 0 RNA binding motif HAD_2 PF13419.6 PIK61833.1 - 0.1 12.7 0.3 0.28 11.2 0.3 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF5105 PF17118.5 PIK61833.1 - 0.13 12.1 0.3 0.46 10.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5105) UMP1 PF05348.11 PIK61834.1 - 1.2e-26 93.2 0.1 1.4e-26 93.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 EndIII_4Fe-2S PF10576.9 PIK61835.1 - 0.0058 16.9 3.2 0.0058 16.9 3.2 2.7 2 0 0 2 2 2 1 Iron-sulfur binding domain of endonuclease III AMP-binding PF00501.28 PIK61836.1 - 6.1e-96 321.6 0.0 8.6e-96 321.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SAPS PF04499.15 PIK61836.1 - 0.043 12.6 0.0 0.067 12.0 0.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cadherin PF00028.17 PIK61837.1 - 1.1e-64 214.9 26.5 1.4e-11 44.6 0.3 9.1 9 0 0 9 9 9 7 Cadherin domain Cadherin_3 PF16184.5 PIK61837.1 - 5.6e-17 61.7 13.2 0.0013 18.8 0.1 6.8 6 0 0 6 6 6 5 Cadherin-like Cadherin_2 PF08266.12 PIK61837.1 - 0.002 17.9 0.1 0.17 11.7 0.1 3.7 4 0 0 4 4 4 1 Cadherin-like RET_CLD1 PF17756.1 PIK61837.1 - 0.0044 17.3 0.0 0.74 10.1 0.0 3.4 2 0 0 2 2 2 1 RET Cadherin like domain 1 KSHV_K8 PF07188.11 PIK61837.1 - 0.031 13.7 0.3 0.057 12.8 0.3 1.4 1 0 0 1 1 1 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein Cadherin PF00028.17 PIK61838.1 - 3.2e-35 120.4 9.2 8e-14 51.9 0.2 5.6 5 1 1 6 6 6 4 Cadherin domain Cadherin PF00028.17 PIK61839.1 - 1.5e-44 150.4 18.1 1.3e-11 44.8 0.6 7.9 8 0 0 8 8 8 6 Cadherin domain Cadherin_3 PF16184.5 PIK61839.1 - 0.034 14.1 13.1 0.58 10.2 0.1 6.9 8 1 0 8 8 8 0 Cadherin-like Cadherin PF00028.17 PIK61840.1 - 1.2e-28 99.4 8.0 3.8e-09 36.9 0.0 5.0 5 1 1 6 6 6 4 Cadherin domain Cadherin_3 PF16184.5 PIK61840.1 - 0.0025 17.8 1.3 0.022 14.8 0.2 2.7 2 0 0 2 2 2 1 Cadherin-like Mannosidase_ig PF17786.1 PIK61840.1 - 0.13 12.9 1.7 0.66 10.6 0.2 3.1 2 1 1 3 3 3 0 Mannosidase Ig/CBM-like domain Calx-beta PF03160.14 PIK61840.1 - 0.27 11.4 11.3 0.94 9.7 1.2 3.6 2 2 2 4 4 4 0 Calx-beta domain Cadherin PF00028.17 PIK61841.1 - 1.2e-14 54.5 12.4 0.00011 22.6 0.1 5.9 6 1 0 6 6 6 3 Cadherin domain Cadherin_pro PF08758.11 PIK61841.1 - 7e-05 22.9 0.2 0.027 14.6 0.1 2.9 2 0 0 2 2 2 2 Cadherin prodomain like Sulfotransfer_2 PF03567.14 PIK61842.1 - 0.0018 18.2 0.2 0.0056 16.6 0.1 1.8 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 PIK61843.1 - 3.9e-18 66.3 0.1 5.6e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK61843.1 - 0.00085 18.9 0.7 0.0038 16.8 0.1 2.1 2 1 0 2 2 2 1 Sulfotransferase domain Gal-3-0_sulfotr PF06990.11 PIK61843.1 - 0.0019 17.2 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase AAA_12 PF13087.6 PIK61843.1 - 0.02 14.5 1.0 0.13 11.9 0.7 2.1 1 1 1 2 2 2 0 AAA domain DUF3405 PF11885.8 PIK61843.1 - 0.13 10.9 0.1 0.18 10.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) COMPASS-Shg1 PF05205.12 PIK61843.1 - 0.14 12.9 3.2 1.1 10.0 1.4 2.7 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 Sulfotransfer_2 PF03567.14 PIK61844.1 - 1.1e-14 55.0 2.4 1.5e-14 54.5 2.4 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK61844.1 - 6.4e-10 39.0 0.6 3.1e-09 36.7 0.6 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Lysyl_oxidase PF01186.17 PIK61844.1 - 0.043 13.5 0.1 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 Lysyl oxidase DUF4129 PF13559.6 PIK61844.1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) Death PF00531.22 PIK61845.1 - 0.047 13.9 0.1 9.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Death domain Death PF00531.22 PIK61846.1 - 4.4e-12 46.0 1.6 2.4e-05 24.4 0.0 3.3 3 0 0 3 3 3 3 Death domain Helicase_Sgs1 PF11408.8 PIK61846.1 - 0.066 13.3 0.2 0.38 10.8 0.1 2.3 3 0 0 3 3 3 0 Sgs1 RecQ helicase JAB PF01398.21 PIK61847.1 - 4.5e-17 62.1 0.0 5.5e-16 58.6 0.0 2.5 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 PIK61847.1 - 3.8e-10 39.9 0.8 8.6e-10 38.8 0.8 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 PIK61847.1 - 1.7e-05 24.6 0.0 1.7e-05 24.6 0.0 2.1 2 1 0 2 2 2 1 Prokaryotic homologs of the JAB domain Zip PF02535.22 PIK61847.1 - 0.28 10.4 1.3 0.38 9.9 1.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GST_C_3 PF14497.6 PIK61848.1 - 7.8e-06 26.0 0.0 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK61848.1 - 0.025 14.9 0.0 0.046 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain IGR PF09597.10 PIK61849.1 - 0.051 13.7 1.1 9.2 6.5 0.2 2.7 3 0 0 3 3 3 0 IGR protein motif Peptidase_U49 PF10463.9 PIK61849.1 - 0.052 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase U49 GST_N PF02798.20 PIK61850.1 - 2.9e-11 43.6 0.0 3.4e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 PIK61850.1 - 1.6e-06 28.4 0.0 2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK61850.1 - 0.00069 20.3 0.0 0.00079 20.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 PIK61850.1 - 0.0038 17.5 0.0 0.0042 17.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain LRR_4 PF12799.7 PIK61852.1 - 0.0022 18.4 0.6 0.52 10.8 0.1 2.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK61852.1 - 0.0027 18.0 0.8 4.3 8.3 0.1 3.2 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 PIK61852.1 - 0.019 15.0 1.8 1.3 9.3 0.4 2.8 3 0 0 3 3 3 0 Leucine Rich repeat AAA_12 PF13087.6 PIK61853.1 - 2.4e-46 157.9 0.0 8.3e-46 156.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK61853.1 - 2.8e-20 73.2 7.6 4.7e-13 49.5 0.1 3.6 3 1 1 4 4 4 2 AAA domain zf-GRF PF06839.12 PIK61853.1 - 7.4e-09 35.6 5.7 1.6e-08 34.5 5.7 1.6 1 0 0 1 1 1 1 GRF zinc finger Viral_helicase1 PF01443.18 PIK61853.1 - 0.00028 20.7 0.1 1.9 8.2 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 PIK61853.1 - 0.017 15.0 0.0 0.042 13.7 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 PIK61853.1 - 0.059 13.1 0.0 15 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain MitoNEET_N PF10660.9 PIK61854.1 - 0.053 13.6 0.0 0.58 10.2 0.0 2.2 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF2439 PF10382.9 PIK61856.1 - 3e-20 72.3 1.3 8.5e-20 70.9 1.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DNA_pol_B_palm PF14792.6 PIK61857.1 - 1.2e-34 119.0 0.0 2e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 PIK61857.1 - 8.1e-21 73.6 0.1 2.1e-20 72.3 0.0 1.7 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 PIK61857.1 - 6.1e-18 64.9 0.6 4.2e-16 59.1 0.1 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_5 PF14520.6 PIK61857.1 - 7.7e-08 32.8 0.5 3.8e-06 27.4 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix domain Cdd1 PF11731.8 PIK61857.1 - 0.0011 19.2 0.1 0.018 15.3 0.0 2.5 2 1 1 3 3 3 1 Pathogenicity locus NTP_transf_2 PF01909.23 PIK61857.1 - 0.0055 17.0 0.1 0.015 15.6 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain HHH_2 PF12826.7 PIK61857.1 - 0.0089 16.1 0.0 0.78 9.9 0.0 2.6 2 1 1 3 3 3 1 Helix-hairpin-helix motif HHH_3 PF12836.7 PIK61857.1 - 0.029 14.6 0.1 1.6 9.0 0.0 2.7 2 1 0 2 2 2 0 Helix-hairpin-helix motif HHH PF00633.23 PIK61857.1 - 0.12 12.3 0.1 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif Macro PF01661.21 PIK61858.1 - 5e-29 100.8 1.3 5.4e-29 100.6 0.2 1.6 2 0 0 2 2 2 1 Macro domain Histone_H2A_C PF16211.5 PIK61858.1 - 9.6e-13 47.6 0.5 4.8e-12 45.4 0.5 2.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 PIK61858.1 - 4.5e-12 46.5 0.0 4.5e-12 46.5 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Ion_trans_2 PF07885.16 PIK61859.1 - 3.4e-11 43.0 3.1 5.6e-11 42.2 3.1 1.3 1 0 0 1 1 1 1 Ion channel Ion_trans_2 PF07885.16 PIK61860.1 - 2.7e-19 68.9 11.3 6.7e-19 67.6 8.1 2.1 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 PIK61860.1 - 2.5e-07 30.2 1.6 3.4e-07 29.8 1.6 1.1 1 0 0 1 1 1 1 Ion transport protein ABC_export PF16962.5 PIK61860.1 - 0.0064 15.0 0.0 0.0097 14.4 0.0 1.2 1 0 0 1 1 1 1 Putative ABC exporter Ribophorin_II PF05817.14 PIK61860.1 - 0.067 11.7 0.0 0.11 11.0 0.0 1.3 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Pox_A9 PF04835.12 PIK61860.1 - 0.1 12.8 1.5 0.48 10.6 0.1 2.3 3 0 0 3 3 3 0 A9 protein conserved region V-SNARE PF05008.15 PIK61861.1 - 9.4e-23 80.4 2.7 9.4e-23 80.4 2.7 2.1 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 PIK61861.1 - 1e-17 64.2 3.6 1e-17 64.2 3.6 2.0 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 PIK61861.1 - 0.0024 17.8 0.3 0.0024 17.8 0.3 2.1 2 0 0 2 2 2 1 Sec20 DUF3605 PF12239.8 PIK61861.1 - 0.24 11.7 2.8 0.38 11.1 0.4 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3605) DUF3987 PF13148.6 PIK61861.1 - 0.25 10.3 3.7 0.32 9.9 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF745 PF05335.13 PIK61861.1 - 1.3 8.7 5.0 0.89 9.2 2.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Exonuc_VII_L PF02601.15 PIK61861.1 - 2 7.9 14.2 15 5.0 14.2 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 PIK61861.1 - 2.1 8.4 5.6 1.1 9.3 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_L34e PF01199.18 PIK61862.1 - 1.9e-36 124.2 5.8 2.6e-36 123.8 5.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e UCR_14kD PF02271.16 PIK61863.1 - 1.3e-27 95.7 2.8 1.4e-27 95.6 2.8 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit DUF2795 PF11387.8 PIK61863.1 - 0.091 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) Mob1_phocein PF03637.17 PIK61864.1 - 1.8e-81 272.1 0.2 2.3e-81 271.8 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family MRP-S24 PF14955.6 PIK61865.1 - 9.8e-19 67.7 0.1 2.2e-18 66.5 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial ribosome subunit S24 PP2C PF00481.21 PIK61866.1 - 5.8e-47 160.5 0.2 7.1e-47 160.2 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 PIK61866.1 - 1.1e-11 44.7 0.0 2.3e-11 43.7 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 PIK61866.1 - 0.00033 20.6 0.2 0.33 10.8 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) FANCF PF11107.8 PIK61866.1 - 0.15 11.2 0.1 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) Nfu_N PF08712.11 PIK61867.1 - 5.4e-27 93.7 0.0 1.1e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 PIK61867.1 - 3.3e-14 52.8 0.3 6.2e-14 51.9 0.3 1.5 1 1 0 1 1 1 1 NifU-like domain Y_phosphatase PF00102.27 PIK61868.1 - 4.1e-78 262.2 1.0 5.6e-78 261.7 1.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PDZ PF00595.24 PIK61868.1 - 7.1e-17 61.5 1.2 5.2e-16 58.8 0.7 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 PIK61868.1 - 1e-05 25.3 0.0 2.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DSPc PF00782.20 PIK61868.1 - 0.00047 20.0 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 PIK61868.1 - 0.00081 19.4 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Myotub-related PF06602.14 PIK61868.1 - 0.0026 16.8 0.1 0.0042 16.1 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain PTPlike_phytase PF14566.6 PIK61868.1 - 0.0039 17.3 0.1 0.012 15.7 0.0 1.8 1 1 0 1 1 1 1 Inositol hexakisphosphate PDZ PF00595.24 PIK61869.1 - 1.5e-32 111.8 0.0 7.3e-16 58.3 0.0 2.8 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 PIK61869.1 - 6.7e-13 48.3 0.0 3.5e-06 26.8 0.0 2.8 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK61869.1 - 1.9e-10 40.9 0.0 0.0013 19.0 0.0 3.0 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 PIK61869.1 - 0.0063 16.5 0.1 7.5 6.6 0.0 3.0 3 0 0 3 3 3 2 Tricorn protease PDZ domain PDZ PF00595.24 PIK61871.1 - 1.9e-14 53.8 0.9 4.7e-14 52.5 0.9 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK61871.1 - 3.6e-08 33.1 0.1 7.5e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK61871.1 - 0.00022 21.5 0.1 0.00053 20.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain FERM_M PF00373.18 PIK61872.1 - 3e-08 34.1 0.0 4.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 PIK61872.1 - 0.018 15.4 0.1 0.043 14.2 0.0 1.6 1 1 0 1 1 1 0 FERM C-terminal PH-like domain DUF4763 PF15960.5 PIK61873.1 - 0.00084 18.7 0.1 0.0014 18.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) KIND PF16474.5 PIK61873.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain NDK PF00334.19 PIK61874.1 - 1.3e-39 135.3 0.0 1.7e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 PIK61874.1 - 3e-16 58.8 0.2 5.5e-16 58.0 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif 7tm_3 PF00003.22 PIK61875.1 - 2.1e-11 44.0 20.8 3.5e-11 43.3 20.8 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 PIK61875.1 - 0.014 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Receptor family ligand binding region DUF3493 PF11998.8 PIK61875.1 - 0.89 9.8 3.9 0.54 10.5 0.2 2.4 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 DUF2207 PF09972.9 PIK61875.1 - 1.4 7.6 9.2 0.25 10.1 0.4 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) UPF0182 PF03699.13 PIK61875.1 - 1.5 6.8 12.7 3.8 5.5 12.6 1.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0182) ANF_receptor PF01094.28 PIK61876.1 - 3.1e-14 52.9 0.0 1.2e-13 50.9 0.0 1.8 1 1 0 1 1 1 1 Receptor family ligand binding region WW_like PF17890.1 PIK61876.1 - 0.13 12.4 0.4 2.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Peptidoglycan hydrolase LytB WW-like domain ANF_receptor PF01094.28 PIK61877.1 - 3.4e-65 220.5 0.1 6e-31 107.8 0.0 3.1 3 0 0 3 3 3 3 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK61877.1 - 3.1e-09 37.0 8.5 0.00012 21.9 0.3 3.1 2 1 0 2 2 2 2 Periplasmic binding protein TPT PF03151.16 PIK61878.1 - 7.4e-14 51.8 17.5 9.1e-14 51.5 17.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family Porin_3 PF01459.22 PIK61879.1 - 3.2e-78 262.9 6.4 3.5e-78 262.8 6.4 1.0 1 0 0 1 1 1 1 Eukaryotic porin Ldl_recept_b PF00058.17 PIK61880.1 - 1.1e-38 131.5 9.0 5.9e-07 29.9 0.0 9.8 10 0 0 10 10 10 6 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 PIK61880.1 - 2.3e-13 50.2 47.5 8e-08 32.4 6.8 4.4 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 PIK61880.1 - 1.1e-10 41.3 0.1 7.9e-06 25.3 0.0 3.4 1 1 2 3 3 3 3 Domain of unknown function (DUF5050) cEGF PF12662.7 PIK61880.1 - 1.7e-10 40.6 26.1 0.00044 20.1 0.4 4.7 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK61880.1 - 1.8e-05 24.8 6.2 1.8e-05 24.8 6.2 6.0 7 1 0 7 7 7 2 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.11 PIK61880.1 - 0.032 14.5 25.2 1.6 9.1 5.6 3.6 2 1 1 3 3 3 0 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 PIK61880.1 - 0.18 11.9 21.3 0.17 12.0 7.0 3.6 3 0 0 3 3 3 0 MSP1 EGF domain 1 EGF PF00008.27 PIK61880.1 - 0.34 11.3 36.2 0.079 13.3 8.4 4.7 4 0 0 4 4 4 0 EGF-like domain Prefoldin_2 PF01920.20 PIK61881.1 - 6.9e-20 71.0 10.7 8.3e-20 70.7 10.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit Herpes_UL6 PF01763.16 PIK61881.1 - 0.12 10.9 3.7 0.19 10.2 3.3 1.6 1 1 0 1 1 1 0 Herpesvirus UL6 like Spc24 PF08286.11 PIK61881.1 - 2.2 8.6 8.6 3.2 8.1 2.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 TMF_DNA_bd PF12329.8 PIK61881.1 - 2.3 8.3 12.3 2.7 8.1 2.0 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding XhlA PF10779.9 PIK61881.1 - 6.3 7.1 6.2 3.7 7.8 1.0 2.2 2 0 0 2 2 2 0 Haemolysin XhlA Pex14_N PF04695.13 PIK61882.1 - 1.8 9.2 6.7 2.1 9.0 6.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ubiquitin PF00240.23 PIK61884.1 - 3.8e-19 68.2 0.0 4.3e-19 68.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 PIK61884.1 - 8.4e-05 22.9 0.0 0.00026 21.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 PIK61884.1 - 0.00033 20.4 0.0 0.00038 20.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like KH_1 PF00013.29 PIK61885.1 - 9.7e-28 95.8 7.4 1.6e-12 47.1 1.1 5.3 5 0 0 5 5 5 3 KH domain SAM_1 PF00536.30 PIK61885.1 - 1.7e-11 44.4 0.0 3.3e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK61885.1 - 1.7e-09 37.7 0.0 4.4e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_10 PF17905.1 PIK61885.1 - 2e-06 28.2 0.7 0.00095 19.6 0.1 3.3 3 0 0 3 3 3 2 GLD-3 KH domain 5 Drc1-Sld2 PF11719.8 PIK61886.1 - 0.025 14.1 3.3 0.025 14.1 3.3 2.0 2 0 0 2 2 2 0 DNA replication and checkpoint protein Nexin_C PF08628.12 PIK61886.1 - 0.034 14.7 0.8 0.071 13.7 0.8 1.5 1 0 0 1 1 1 0 Sorting nexin C terminal Occludin_ELL PF07303.13 PIK61886.1 - 3.3 8.5 12.0 1.7 9.4 0.6 3.1 2 1 1 3 3 3 0 Occludin homology domain DUF4407 PF14362.6 PIK61887.1 - 0.0058 16.0 8.1 0.0069 15.8 8.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Drc1-Sld2 PF11719.8 PIK61887.1 - 0.023 14.2 16.1 0.024 14.2 10.7 2.0 1 1 1 2 2 2 0 DNA replication and checkpoint protein TRAF_BIRC3_bd PF16673.5 PIK61887.1 - 0.057 13.2 1.7 1.8 8.4 0.1 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF4953 PF16313.5 PIK61887.1 - 0.076 12.2 3.3 0.13 11.4 1.9 1.7 1 1 1 2 2 2 0 Met-zincin CotJB PF12652.7 PIK61887.1 - 0.077 13.2 2.8 1.1 9.5 0.3 2.6 2 0 0 2 2 2 0 CotJB protein Lipoprotein_2 PF00921.17 PIK61887.1 - 0.1 12.2 5.8 0.13 11.8 5.8 1.1 1 0 0 1 1 1 0 Borrelia lipoprotein Jnk-SapK_ap_N PF09744.9 PIK61887.1 - 0.12 12.6 13.7 0.29 11.3 10.8 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliJ PF02050.16 PIK61887.1 - 0.13 12.5 8.7 2.3 8.5 0.7 2.5 2 1 0 2 2 2 0 Flagellar FliJ protein SlyX PF04102.12 PIK61887.1 - 0.14 12.8 10.0 0.29 11.8 1.0 2.7 2 1 1 3 3 2 0 SlyX ISG65-75 PF11727.8 PIK61887.1 - 0.16 11.2 13.7 0.27 10.4 13.7 1.4 1 1 0 1 1 1 0 Invariant surface glycoprotein Exonuc_VII_L PF02601.15 PIK61887.1 - 0.16 11.5 5.5 0.2 11.2 5.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit LPP PF04728.13 PIK61887.1 - 0.23 11.9 6.2 0.56 10.6 2.0 2.9 2 1 0 2 2 2 0 Lipoprotein leucine-zipper V_ATPase_I PF01496.19 PIK61887.1 - 0.27 9.1 9.6 0.33 8.8 9.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.25 PIK61887.1 - 0.33 10.6 8.9 0.52 9.9 8.9 1.4 1 0 0 1 1 1 0 Syntaxin Laminin_II PF06009.12 PIK61887.1 - 0.41 10.7 9.5 0.14 12.1 5.6 2.0 1 1 0 2 2 2 0 Laminin Domain II PIN_8 PF18476.1 PIK61887.1 - 0.42 10.4 9.5 0.44 10.4 8.7 1.4 1 1 0 1 1 1 0 PIN like domain ING PF12998.7 PIK61887.1 - 0.55 10.9 8.6 0.45 11.1 3.7 2.4 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding ATPase PF06745.13 PIK61887.1 - 0.63 9.3 3.0 0.61 9.4 1.9 1.5 1 1 1 2 2 2 0 KaiC GET2 PF08690.10 PIK61887.1 - 0.71 9.5 10.7 0.91 9.1 10.7 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 CSN5_C PF18323.1 PIK61887.1 - 1.2 10.1 10.8 44 5.1 10.6 2.4 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain DivIC PF04977.15 PIK61887.1 - 1.4 8.7 7.7 0.23 11.3 1.0 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF3573 PF12097.8 PIK61887.1 - 2.4 6.9 4.3 1.7 7.3 2.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) Pex19 PF04614.12 PIK61887.1 - 3.2 7.5 15.8 0.96 9.2 11.3 1.9 1 1 1 2 2 2 0 Pex19 protein family DUF668 PF05003.12 PIK61887.1 - 3.4 8.2 5.6 5.8 7.5 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF668) FlxA PF14282.6 PIK61887.1 - 3.4 7.7 15.5 0.34 10.9 2.4 2.6 1 1 2 3 3 3 0 FlxA-like protein TMPIT PF07851.13 PIK61887.1 - 3.8 6.7 9.1 6 6.0 9.1 1.5 1 0 0 1 1 1 0 TMPIT-like protein DUF2203 PF09969.9 PIK61887.1 - 4.2 8.1 11.1 1.1 10.0 5.6 2.4 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Uso1_p115_C PF04871.13 PIK61887.1 - 5.1 7.5 20.9 1.3 9.4 15.9 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FapA PF03961.13 PIK61887.1 - 7.1 5.1 12.1 7 5.1 11.1 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 PIK61887.1 - 9.4 6.9 12.4 42 4.8 0.3 2.9 1 1 0 2 2 2 0 Initiation control protein YabA RhoGAP PF00620.27 PIK61889.1 - 9e-14 51.6 0.0 1.6e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain zf-CDGSH PF09360.10 PIK61890.1 - 1.2e-10 41.4 1.8 1.7e-10 41.0 1.8 1.5 1 1 0 1 1 1 1 Iron-binding zinc finger CDGSH type Sulfotransfer_3 PF13469.6 PIK61892.1 - 0.0021 18.5 0.0 0.0026 18.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Vsr PF03852.15 PIK61892.1 - 0.11 12.4 0.0 1.1 9.2 0.0 2.2 1 1 0 1 1 1 0 DNA mismatch endonuclease Vsr RT_RNaseH PF17917.1 PIK61893.1 - 1.8e-16 60.3 0.2 2.7e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK61893.1 - 2.5e-14 53.3 0.0 3.5e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK61893.1 - 5.2e-09 36.1 0.1 9e-09 35.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK61895.1 - 6.6e-13 48.9 0.1 1.4e-12 47.8 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 PIK61895.1 - 1.6e-08 34.2 0.5 3.5e-08 33.1 0.1 1.7 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 PIK61896.1 - 6.9e-05 23.1 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK61896.1 - 0.056 13.0 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TrmB PF01978.19 PIK61896.1 - 0.14 12.1 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Hormone_2 PF00123.20 PIK61896.1 - 0.36 10.8 1.7 13 5.8 0.0 2.9 3 0 0 3 3 3 0 Peptide hormone TNV_CP PF03898.13 PIK61897.1 - 0.24 10.6 0.0 0.3 10.3 0.0 1.1 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Sulfotransfer_3 PF13469.6 PIK61898.1 - 0.00077 19.9 0.0 0.0014 19.1 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase family SNF PF00209.18 PIK61899.1 - 2.3e-20 72.8 6.5 2.7e-20 72.6 6.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF4534 PF15049.6 PIK61899.1 - 2.2 8.0 8.5 1.5 8.6 7.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4534) SNF PF00209.18 PIK61900.1 - 3.8e-24 85.3 2.6 3.9e-24 85.3 2.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family LRR_8 PF13855.6 PIK61901.1 - 6e-46 154.1 58.4 5.2e-13 48.5 4.2 5.1 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 PIK61901.1 - 8e-21 73.8 26.6 2e-05 24.8 1.3 6.2 4 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK61901.1 - 1.5e-14 54.1 5.3 2.9e-07 30.5 0.3 2.5 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK61901.1 - 1.2e-10 40.4 22.3 0.039 14.5 0.2 8.4 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 PIK61901.1 - 4.6e-07 29.5 14.2 0.00091 18.8 4.9 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_2 PF07723.13 PIK61901.1 - 0.021 15.5 1.6 10 7.0 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat Pou PF00157.17 PIK61901.1 - 0.1 12.6 0.1 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Pou domain - N-terminal to homeobox domain DUF3557 PF12078.8 PIK61901.1 - 0.11 12.4 2.5 0.35 10.8 2.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) LRR_6 PF13516.6 PIK61901.1 - 0.36 11.0 25.7 1.8 8.9 0.3 6.6 7 0 0 7 7 7 0 Leucine Rich repeat Methyltransf_FA PF12248.8 PIK61902.1 - 2.4e-31 108.1 0.0 3.5e-16 59.4 0.0 3.4 3 0 0 3 3 3 3 Farnesoic acid 0-methyl transferase Gal_Lectin PF02140.18 PIK61902.1 - 5.3e-17 62.0 11.9 3.5e-12 46.6 1.3 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain SYCP2_SLD PF18584.1 PIK61902.1 - 0.055 13.7 0.1 6.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Synaptonemal complex 2 Spt16M-like domain 7tm_1 PF00001.21 PIK61904.1 - 0.013 14.8 0.1 0.014 14.8 0.1 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EcpB_C PF18649.1 PIK61905.1 - 0.07 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 EcpB C-terminal domain Herpes_IE2_3 PF03361.14 PIK61905.1 - 0.085 12.7 2.8 1.5 8.7 0.4 2.0 1 1 1 2 2 2 0 Herpes virus intermediate/early protein 2/3 Methyltransf_FA PF12248.8 PIK61906.1 - 1.6e-08 34.8 0.0 2.6e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase DUF4573 PF15140.6 PIK61906.1 - 6.2e-07 29.4 4.0 8.8e-07 28.9 4.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Amelogenin PF02948.15 PIK61906.1 - 0.00039 21.1 20.4 0.12 13.0 6.1 2.5 1 1 1 2 2 2 2 Amelogenin PH_16 PF17838.1 PIK61907.1 - 0.00014 21.7 0.0 0.00056 19.7 0.0 1.9 1 1 0 1 1 1 1 PH domain RBD PF02196.15 PIK61907.1 - 0.001 19.1 0.0 0.0029 17.7 0.0 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH_13 PF16652.5 PIK61907.1 - 0.0016 18.3 0.2 0.0052 16.6 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_5 PF15405.6 PIK61907.1 - 0.013 15.6 0.3 0.013 15.6 0.3 2.7 3 1 1 4 4 4 0 Pleckstrin homology domain ZU5 PF00791.20 PIK61908.1 - 1.9e-13 50.6 0.0 6.7e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain LRR_6 PF13516.6 PIK61909.1 - 3.9e-09 35.8 0.6 0.06 13.4 0.0 5.2 5 0 0 5 5 5 3 Leucine Rich repeat F-box-like PF12937.7 PIK61909.1 - 5.5e-08 32.6 3.4 5.5e-08 32.6 1.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK61909.1 - 9.8e-07 28.5 2.4 2.5e-06 27.2 1.1 2.1 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 PIK61909.1 - 0.00049 20.4 0.0 3.6 8.1 0.0 3.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK61909.1 - 0.00061 20.0 0.1 29 5.7 0.0 5.0 5 0 0 5 5 5 1 Leucine Rich Repeat F-box-like_2 PF13013.6 PIK61909.1 - 0.02 14.8 1.0 0.16 11.9 1.0 2.4 1 1 0 1 1 1 0 F-box-like domain Utp21 PF04192.12 PIK61910.1 - 1.1e-62 211.6 0.8 1.8e-62 210.9 0.8 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 PIK61910.1 - 3.7e-18 65.6 19.5 3.7e-07 30.7 0.2 10.5 11 0 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK61910.1 - 2.7e-11 43.6 2.2 0.0073 16.6 0.0 5.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 PIK61910.1 - 0.017 13.7 0.1 0.034 12.7 0.1 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain DnaJ PF00226.31 PIK61911.1 - 1.2e-28 99.0 4.3 1.5e-28 98.7 4.3 1.1 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 PIK61911.1 - 0.026 14.5 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 A repeated domain in UCH-protein LprI PF07007.12 PIK61911.1 - 0.07 13.8 0.0 0.079 13.6 0.0 1.1 1 0 0 1 1 1 0 Lysozyme inhibitor LprI DnaJ_C PF01556.18 PIK61912.1 - 4.7e-27 94.9 0.0 5.9e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain GAIN PF16489.5 PIK61913.1 - 2.1e-17 63.3 5.9 2.5e-17 63.0 5.9 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Actin PF00022.19 PIK61913.1 - 0.011 14.4 0.3 0.011 14.3 0.3 1.1 1 0 0 1 1 1 0 Actin DUF1451 PF07295.11 PIK61913.1 - 0.34 11.0 2.5 0.31 11.1 1.4 1.6 1 1 0 1 1 1 0 Zinc-ribbon containing domain 7tm_2 PF00002.24 PIK61914.1 - 8.9e-66 221.7 26.8 8.9e-66 221.7 26.8 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 PIK61914.1 - 6.9e-18 64.9 6.2 1.9e-17 63.5 6.2 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Dicty_CAR PF05462.11 PIK61914.1 - 1.2e-07 31.2 23.3 1.7e-07 30.7 23.3 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor CrgA PF06781.12 PIK61914.1 - 0.0088 16.1 1.7 0.032 14.3 1.7 2.0 1 0 0 1 1 1 1 Cell division protein CrgA RL11D PF11088.8 PIK61914.1 - 0.057 13.7 1.1 0.12 12.7 1.1 1.5 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 DUF1230 PF06799.11 PIK61914.1 - 2.7 8.1 7.3 0.18 11.9 1.3 2.0 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 SDF PF00375.18 PIK61915.1 - 4.7e-93 312.3 19.0 6.1e-93 311.9 19.0 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family EspA PF03433.13 PIK61916.1 - 0.045 13.6 0.7 0.045 13.6 0.7 1.8 3 0 0 3 3 3 0 EspA-like secreted protein FGE-sulfatase PF03781.16 PIK61917.1 - 1.8e-27 96.6 3.5 1.6e-13 50.8 0.1 3.1 1 1 1 2 2 2 2 Sulfatase-modifying factor enzyme 1 Methyltransf_25 PF13649.6 PIK61917.1 - 0.00023 21.8 0.1 0.00092 19.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK61917.1 - 0.00023 21.0 0.0 0.00051 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK61917.1 - 0.00063 20.3 0.0 0.0025 18.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK61917.1 - 0.00075 19.3 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK61917.1 - 0.014 16.1 0.0 0.043 14.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain UIM PF02809.20 PIK61918.1 - 2.3e-08 33.4 16.0 0.0026 17.6 0.2 3.9 3 0 0 3 3 3 3 Ubiquitin interaction motif VWA_2 PF13519.6 PIK61918.1 - 0.025 15.2 0.1 0.31 11.7 0.0 2.9 4 0 0 4 4 4 0 von Willebrand factor type A domain RAP80_UIM PF18282.1 PIK61918.1 - 0.055 13.2 10.0 0.75 9.6 0.4 3.5 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif zf-C3HC4_3 PF13920.6 PIK61919.1 - 1.4e-13 50.4 9.8 2.1e-13 49.9 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK61919.1 - 0.00012 21.8 10.0 0.0002 21.1 10.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 PIK61919.1 - 0.0017 18.6 11.7 0.0029 17.9 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK61919.1 - 0.034 14.0 13.3 0.056 13.3 13.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK61919.1 - 0.037 14.0 10.2 0.063 13.2 10.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain C1_2 PF03107.16 PIK61919.1 - 1.9 8.9 8.7 11 6.4 0.3 2.5 1 1 1 2 2 2 0 C1 domain Utp21 PF04192.12 PIK61920.1 - 0.028 13.9 1.5 0.046 13.2 1.5 1.3 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain Microvir_H PF04687.12 PIK61920.1 - 0.058 12.8 0.1 0.084 12.2 0.1 1.2 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) SMC_N PF02463.19 PIK61921.1 - 2e-32 112.4 13.4 2e-32 112.4 13.4 2.5 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 PIK61921.1 - 6.2e-12 45.9 22.1 6.2e-12 45.9 22.1 2.5 1 1 1 2 2 1 1 AAA ATPase domain AAA_23 PF13476.6 PIK61921.1 - 1.7e-10 41.7 77.7 1.6e+02 2.6 77.7 4.8 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 PIK61921.1 - 1.9e-06 28.0 0.0 1.9e-06 28.0 0.0 3.3 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Spc7 PF08317.11 PIK61921.1 - 0.0021 17.0 67.7 0.048 12.5 24.9 4.0 1 1 3 4 4 4 3 Spc7 kinetochore protein AAA_29 PF13555.6 PIK61921.1 - 0.0033 17.1 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATG16 PF08614.11 PIK61921.1 - 0.11 12.7 67.0 0.034 14.4 18.4 4.6 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) WD40_alt PF14077.6 PIK61921.1 - 0.34 10.8 4.8 1.2 9.0 0.0 3.8 3 0 0 3 3 3 0 Alternative WD40 repeat motif AAA_13 PF13166.6 PIK61921.1 - 0.46 9.1 55.1 4.1 5.9 0.0 3.3 2 1 1 3 3 3 0 AAA domain KASH_CCD PF14662.6 PIK61921.1 - 3.2 7.5 66.2 1.8 8.4 19.0 3.7 1 1 2 3 3 2 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 PIK61921.1 - 5.3 7.6 79.4 3.5 8.2 18.2 4.7 1 1 3 4 4 4 0 Apg6 coiled-coil region FlaC_arch PF05377.11 PIK61921.1 - 6.2 7.3 41.3 0.69 10.3 1.1 6.8 5 2 2 7 7 7 0 Flagella accessory protein C (FlaC) SMC_hinge PF06470.13 PIK61922.1 - 2.9e-21 76.0 0.0 8.5e-21 74.4 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain EMP24_GP25L PF01105.24 PIK61922.1 - 0.0081 16.1 1.8 0.0081 16.1 1.8 3.1 3 0 0 3 3 3 1 emp24/gp25L/p24 family/GOLD FUSC-like PF12805.7 PIK61922.1 - 0.29 10.2 2.0 0.27 10.3 0.1 2.0 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS HrpB7 PF09486.10 PIK61922.1 - 0.71 10.2 16.2 0.68 10.3 3.2 3.1 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF2019 PF09450.10 PIK61922.1 - 2.1 8.4 5.4 2.5 8.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2019) Nup54 PF13874.6 PIK61922.1 - 5.9 7.0 23.9 1.5 8.9 7.5 3.2 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 PAN_1 PF00024.26 PIK61923.1 - 8.3e-07 28.9 0.1 8.3e-07 28.9 0.1 2.6 2 1 0 2 2 2 1 PAN domain PAN_4 PF14295.6 PIK61923.1 - 0.057 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 PAN domain TetR_C_31 PF17940.1 PIK61924.1 - 0.19 11.9 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Cwf_Cwc_15 PF04889.12 PIK61924.1 - 0.39 10.4 6.3 0.75 9.5 6.3 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein C2 PF00168.30 PIK61925.1 - 4e-05 23.8 0.1 0.0001 22.5 0.1 1.7 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 PIK61925.1 - 0.055 13.0 1.0 0.11 12.1 0.4 1.7 2 0 0 2 2 2 0 CEP76 C2 domain Imm64 PF15600.6 PIK61925.1 - 0.1 12.3 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 64 DUF588 PF04535.12 PIK61926.1 - 0.084 12.6 1.7 2.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF588) Amastin PF07344.11 PIK61926.1 - 0.57 10.0 5.6 1.7 8.5 5.6 1.8 1 1 0 1 1 1 0 Amastin surface glycoprotein BcrAD_BadFG PF01869.20 PIK61927.1 - 3.7e-16 59.4 0.1 4.6e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Hexokinase_2 PF03727.16 PIK61927.1 - 0.034 13.6 0.4 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Hexokinase DHDPS PF00701.22 PIK61928.1 - 2.2e-56 190.7 0.0 2.8e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF4443 PF14544.6 PIK61928.1 - 0.012 15.8 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4443) FAM193_C PF15914.5 PIK61929.1 - 1.5e-21 75.8 4.7 4.3e-21 74.4 4.7 1.9 1 0 0 1 1 1 1 FAM193 family C-terminal RYDR_ITPR PF01365.21 PIK61929.1 - 0.068 12.6 1.5 0.18 11.2 1.2 1.8 2 0 0 2 2 2 0 RIH domain 7tm_1 PF00001.21 PIK61930.1 - 1.1e-50 172.4 25.2 1.4e-50 172.1 25.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK61930.1 - 1.3e-08 34.6 24.3 1.6e-08 34.3 24.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 PIK61930.1 - 0.0084 15.9 15.9 0.014 15.1 15.9 1.4 1 1 0 1 1 1 1 Olfactory receptor zf-TRAF_2 PF15965.5 PIK61931.1 - 5.2e-21 74.9 17.9 9.1e-21 74.1 17.9 1.3 1 0 0 1 1 1 1 TRAF-like zinc-finger F-box_4 PF15966.5 PIK61931.1 - 3.5e-13 49.4 1.3 4.8e-13 49.0 0.1 1.8 2 0 0 2 2 2 1 F-box F-box PF00646.33 PIK61931.1 - 1.5e-05 24.7 5.1 7.6e-05 22.5 0.9 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 PIK61931.1 - 0.0018 18.1 0.5 0.042 13.7 0.1 2.4 2 0 0 2 2 2 1 F-box-like zf-TRAF PF02176.18 PIK61931.1 - 0.0021 18.7 7.7 0.0021 18.7 7.7 1.9 2 1 0 2 2 2 1 TRAF-type zinc finger Erf4 PF10256.9 PIK61932.1 - 4.6e-19 68.6 0.0 6e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Syja_N PF02383.18 PIK61934.1 - 2.3e-79 267.0 0.4 4.1e-79 266.2 0.4 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 PIK61934.1 - 1.9e-21 75.9 0.6 1.1e-20 73.4 0.2 2.4 2 0 0 2 2 2 1 Inositol phosphatase eRF1_2 PF03464.15 PIK61935.1 - 4.4e-48 163.0 0.0 7e-48 162.3 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 PIK61935.1 - 5.9e-39 133.1 0.2 1.3e-38 131.9 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 PIK61935.1 - 6.8e-19 68.1 0.0 1.4e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 PIK61935.1 - 5.6e-10 39.6 0.0 8.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 PIK61935.1 - 5.3e-09 36.4 0.0 8.9e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 DnaJ PF00226.31 PIK61936.1 - 1.9e-18 66.3 0.2 1.9e-18 66.3 0.2 2.6 3 0 0 3 3 1 1 DnaJ domain TPR_2 PF07719.17 PIK61936.1 - 1.4e-15 56.1 3.5 0.00012 21.9 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61936.1 - 2.5e-15 55.5 3.8 1.1e-05 25.0 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61936.1 - 5.6e-15 54.2 2.0 0.0002 21.3 0.1 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat RRM_1 PF00076.22 PIK61936.1 - 1.3e-12 47.3 0.0 1.8e-11 43.7 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_16 PF13432.6 PIK61936.1 - 2.3e-09 37.8 0.7 8.6e-05 23.1 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 PIK61936.1 - 4.2e-09 35.9 3.4 5.5e-05 22.8 0.0 3.8 2 1 1 3 3 3 3 TPR repeat TPR_14 PF13428.6 PIK61936.1 - 4.9e-06 26.9 0.5 0.054 14.3 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61936.1 - 8.5e-06 26.2 0.7 0.0014 19.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61936.1 - 0.00015 22.0 1.3 0.042 14.1 0.5 3.0 1 1 0 2 2 2 1 Tetratricopeptide repeat Spt20 PF12090.8 PIK61936.1 - 0.0027 17.4 14.9 0.0027 17.4 14.9 4.1 2 1 0 2 2 1 1 Spt20 family RRM_occluded PF16842.5 PIK61936.1 - 0.0029 17.4 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 Occluded RNA-recognition motif TPR_7 PF13176.6 PIK61936.1 - 0.0034 17.3 1.5 1.1 9.4 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 PIK61936.1 - 0.011 15.9 0.0 0.8 9.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RPT PF13446.6 PIK61936.1 - 0.018 14.9 0.0 0.44 10.5 0.0 2.9 2 1 1 3 3 3 0 A repeated domain in UCH-protein TPR_3 PF07720.12 PIK61936.1 - 0.037 14.0 0.1 0.16 12.0 0.0 2.2 2 0 0 2 2 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK61936.1 - 0.037 14.3 0.1 0.13 12.5 0.1 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 PIK61936.1 - 0.043 14.5 2.6 23 5.9 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK61936.1 - 0.065 13.1 2.2 21 5.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK61936.1 - 0.093 13.2 0.5 6.5 7.4 0.0 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat SOG2 PF10428.9 PIK61936.1 - 5.8 6.0 35.2 3.2 6.9 24.7 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein PH PF00169.29 PIK61938.1 - 7e-27 94.0 1.2 4.1e-16 59.4 0.2 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 PIK61938.1 - 4.1e-12 46.5 1.4 2.1e-08 34.5 0.6 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 PIK61938.1 - 2.7e-08 34.2 0.6 0.0029 18.0 0.0 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 PIK61938.1 - 7e-06 26.4 0.2 0.0045 17.3 0.0 2.9 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PH_13 PF16652.5 PIK61938.1 - 5.8e-05 23.0 0.2 0.006 16.4 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 PIK61938.1 - 8.8e-05 22.7 0.3 0.0024 18.1 0.2 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 PIK61938.1 - 0.00053 20.3 0.0 0.31 11.3 0.0 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 PIK61938.1 - 0.00073 19.6 0.5 0.043 13.9 0.1 2.5 2 1 0 2 2 2 1 PH domain Sec3-PIP2_bind PF15277.6 PIK61938.1 - 0.11 12.7 0.3 0.35 11.0 0.1 1.9 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH 3Beta_HSD PF01073.19 PIK61940.1 - 4.6e-71 239.1 0.0 6e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 PIK61940.1 - 1.7e-21 76.8 0.0 2.2e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 PIK61940.1 - 2.3e-14 53.2 0.1 1.4e-09 37.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 PIK61940.1 - 3.2e-11 42.9 0.2 1.5e-10 40.7 0.2 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 PIK61940.1 - 3.2e-10 40.2 0.0 6.1e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 PIK61940.1 - 5.6e-09 35.8 0.0 9.9e-08 31.7 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 PIK61940.1 - 4.3e-08 32.6 0.0 6.5e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 PIK61940.1 - 0.0009 19.2 0.1 0.27 11.1 0.1 2.3 2 0 0 2 2 2 2 KR domain NmrA PF05368.13 PIK61940.1 - 0.0036 16.9 0.0 0.0092 15.6 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 PIK61940.1 - 0.0065 15.9 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase IFRD PF05004.13 PIK61941.1 - 5.1e-09 35.7 6.9 5.8e-07 28.9 3.7 2.1 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 PIK61941.1 - 0.00023 21.1 2.9 6.5 7.3 0.1 4.6 4 0 0 4 4 4 2 HEAT repeat DUF3385 PF11865.8 PIK61941.1 - 0.0045 16.9 0.1 1.6 8.6 0.0 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 PIK61941.1 - 0.012 16.1 0.6 4.6 7.9 0.1 3.4 2 1 2 4 4 4 0 HEAT-like repeat RICTOR_V PF14668.6 PIK61941.1 - 0.094 13.0 0.6 2.6 8.4 0.2 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 PhageMin_Tail PF10145.9 PIK61941.1 - 0.099 12.5 0.5 4 7.3 0.5 2.2 1 1 0 1 1 1 0 Phage-related minor tail protein DUF418 PF04235.12 PIK61942.1 - 0.017 15.1 12.0 0.049 13.6 12.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF418) Acyl_transf_3 PF01757.22 PIK61943.1 - 0.19 10.7 8.1 0.066 12.3 5.4 1.5 2 0 0 2 2 2 0 Acyltransferase family Y_phosphatase PF00102.27 PIK61944.1 - 5e-44 150.6 0.8 6.2e-44 150.3 0.8 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Piezo_RRas_bdg PF12166.8 PIK61945.1 - 6.8e-120 401.2 0.0 1.3e-119 400.3 0.0 1.5 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain SR-25 PF10500.9 PIK61945.1 - 0.21 11.2 22.9 0.48 10.0 22.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GAGA_bind PF06217.12 PIK61945.1 - 0.3 11.3 12.6 0.58 10.4 12.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Smg8_Smg9 PF10220.9 PIK61945.1 - 0.78 8.0 6.3 1.3 7.2 6.3 1.3 1 0 0 1 1 1 0 Smg8_Smg9 SAPS PF04499.15 PIK61945.1 - 1.4 7.6 11.8 2.5 6.8 11.8 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein U79_P34 PF03064.16 PIK61945.1 - 1.5 8.1 16.2 2.9 7.2 16.2 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 GET2 PF08690.10 PIK61945.1 - 2.5 7.7 15.1 15 5.1 11.5 2.5 2 1 0 2 2 2 0 GET complex subunit GET2 NPR3 PF03666.13 PIK61945.1 - 3.2 6.5 18.0 0.54 9.0 13.9 1.8 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 LAP1C PF05609.12 PIK61945.1 - 6.4 5.8 19.1 0.44 9.6 12.7 1.9 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 PIK61945.1 - 7.1 6.6 9.7 0.39 10.7 2.4 2.4 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PIEZO PF15917.5 PIK61946.1 - 8.3e-39 133.4 0.1 8.3e-39 133.4 0.1 2.2 2 0 0 2 2 2 1 Piezo Wzy_C PF04932.15 PIK61946.1 - 0.0015 18.2 1.0 0.0015 18.2 1.0 4.0 3 1 0 3 3 3 2 O-Antigen ligase MerC PF03203.14 PIK61948.1 - 6.6 7.2 12.6 0.29 11.6 4.3 2.4 2 1 0 2 2 2 0 MerC mercury resistance protein FAM92 PF06730.11 PIK61949.1 - 9.6e-72 241.0 13.2 9.6e-72 241.0 13.2 1.8 2 0 0 2 2 2 1 FAM92 protein CorA PF01544.18 PIK61949.1 - 0.049 12.9 0.3 0.049 12.9 0.3 2.5 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein TFIIA PF03153.13 PIK61949.1 - 1.5 8.8 25.8 1.9 8.4 25.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pro_isomerase PF00160.21 PIK61950.1 - 8.4e-46 156.1 0.1 1.1e-45 155.7 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_19 PF14559.6 PIK61951.1 - 1.8e-06 28.4 2.6 0.018 15.5 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61951.1 - 0.00011 22.1 1.4 0.013 15.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK61951.1 - 0.00033 21.2 2.5 0.98 10.4 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK61951.1 - 0.022 14.6 0.9 0.11 12.4 0.0 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 PIK61951.1 - 0.031 14.6 3.0 0.58 10.5 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 PIK61951.1 - 0.097 13.3 7.5 8 7.4 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK61951.1 - 0.35 11.1 2.4 31 4.9 0.1 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 PIK61952.1 - 7e-11 42.3 0.3 1.1e-06 28.9 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 PIK61952.1 - 1.2e-06 28.9 0.9 0.0037 17.7 0.4 3.7 4 1 2 6 6 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 PIK61952.1 - 3.3e-06 26.8 3.2 0.32 11.2 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 PIK61952.1 - 8.7e-05 22.7 11.9 0.021 15.0 0.8 4.1 2 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 PIK61952.1 - 0.00029 20.5 2.1 0.75 9.7 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 PIK61952.1 - 0.00031 20.8 2.1 0.63 10.1 0.2 3.0 2 1 1 3 3 3 2 Putative TPR-like repeat TPR_14 PF13428.6 PIK61952.1 - 0.00075 20.1 0.0 18 6.5 0.0 3.8 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 PIK61952.1 - 0.00097 18.4 0.1 0.0031 16.7 0.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 PIK61952.1 - 0.0035 16.8 0.4 0.0078 15.6 0.4 1.5 2 0 0 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 PIK61952.1 - 0.0041 17.7 0.5 0.87 10.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat SPO22 PF08631.10 PIK61952.1 - 0.0047 16.4 0.3 0.0047 16.4 0.3 2.3 2 1 1 3 3 3 1 Meiosis protein SPO22/ZIP4 like LppC PF04348.13 PIK61952.1 - 0.0051 15.7 0.4 0.0071 15.2 0.4 1.2 1 0 0 1 1 1 1 LppC putative lipoprotein TPR_7 PF13176.6 PIK61952.1 - 0.019 15.0 2.3 10 6.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 PIK61952.1 - 0.02 14.8 1.1 5.8 6.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK61952.1 - 0.033 14.4 2.0 9.9 6.7 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK61952.1 - 0.18 12.3 5.5 6.5 7.4 0.3 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat Lectin_C PF00059.21 PIK61953.1 - 1.7e-16 60.9 0.2 4e-16 59.7 0.2 1.6 1 1 0 1 1 1 1 Lectin C-type domain Rab5ip PF07019.12 PIK61954.1 - 6.3e-09 36.3 0.1 1.3e-08 35.3 0.1 1.5 2 0 0 2 2 2 1 Rab5-interacting protein (Rab5ip) DUF2407_C PF13373.6 PIK61954.1 - 0.031 14.5 0.0 0.049 13.8 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Glycos_transf_2 PF00535.26 PIK61955.1 - 7.7e-32 110.4 0.0 9.9e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 PIK61955.1 - 1.6e-09 38.0 0.0 2.4e-09 37.4 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 PIK61955.1 - 1.3e-06 28.2 0.0 1.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PND PF17949.1 PIK61956.1 - 7.8e-38 129.5 0.1 1.3e-37 128.9 0.1 1.3 1 0 0 1 1 1 1 FANCM pseudonuclease domain HHH_2 PF12826.7 PIK61956.1 - 1e-07 31.9 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 PIK61956.1 - 0.019 15.6 0.0 0.043 14.4 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain CUB PF00431.20 PIK61957.1 - 5.7e-09 36.3 0.1 2.2e-08 34.4 0.1 2.0 1 1 0 1 1 1 1 CUB domain Shisa PF13908.6 PIK61957.1 - 4.4e-08 33.6 12.3 7.9e-08 32.8 12.3 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FAM163 PF15069.6 PIK61957.1 - 0.0014 19.1 3.7 0.0026 18.2 3.7 1.4 1 0 0 1 1 1 1 FAM163 family Prominin PF05478.11 PIK61957.1 - 0.024 12.6 14.1 0.032 12.2 14.1 1.1 1 0 0 1 1 1 0 Prominin EphA2_TM PF14575.6 PIK61957.1 - 0.072 14.0 0.0 0.13 13.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mucin PF01456.17 PIK61957.1 - 0.14 12.2 9.1 0.24 11.4 9.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein RTP1_C1 PF10363.9 PIK61960.1 - 5.1e-36 123.3 1.0 1.4e-34 118.6 0.2 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 PIK61960.1 - 2.5e-08 33.5 1.9 0.007 16.5 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 PIK61960.1 - 3.4e-06 27.3 0.2 0.0063 16.9 0.1 2.5 2 1 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 PIK61960.1 - 4.4e-06 27.1 0.6 0.0058 17.1 0.1 3.2 2 2 1 3 3 3 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 PIK61960.1 - 1.7e-05 25.3 0.1 0.0062 17.1 0.0 2.3 1 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK61960.1 - 5.9e-05 23.2 1.7 0.0027 17.8 0.0 2.7 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Ecm29 PF13001.7 PIK61960.1 - 0.0042 15.8 0.1 0.0056 15.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome stabiliser ParcG PF10274.9 PIK61960.1 - 0.012 15.7 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Parkin co-regulated protein DUF4042 PF13251.6 PIK61960.1 - 0.031 14.0 1.3 2.3 7.9 0.6 2.9 2 2 2 4 4 4 0 Domain of unknown function (DUF4042) RRN3 PF05327.11 PIK61960.1 - 0.036 12.6 0.0 0.057 12.0 0.0 1.3 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Adaptin_N PF01602.20 PIK61960.1 - 0.036 12.6 0.7 0.18 10.4 0.7 1.9 1 1 0 1 1 1 0 Adaptin N terminal region UME PF08064.13 PIK61960.1 - 0.11 12.4 0.3 0.47 10.4 0.0 2.1 3 0 0 3 3 3 0 UME (NUC010) domain DUF4962 PF16332.5 PIK61961.1 - 1.7e-06 26.8 5.2 2.4e-06 26.3 5.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) Hepar_II_III PF07940.13 PIK61961.1 - 0.0039 16.9 0.2 3.1 7.4 0.0 2.9 2 1 0 2 2 2 2 Heparinase II/III-like protein RRM_5 PF13893.6 PIK61961.1 - 0.062 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfotransfer_1 PF00685.27 PIK61962.1 - 1.1e-10 41.4 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK61962.1 - 0.045 14.1 0.0 0.88 9.9 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family Prefoldin_2 PF01920.20 PIK61963.1 - 7.1e-22 77.4 10.3 8.5e-22 77.1 10.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 PIK61963.1 - 0.0013 18.7 10.5 0.012 15.5 0.6 2.1 1 1 1 2 2 2 2 Prefoldin subunit UPF0242 PF06785.11 PIK61963.1 - 0.0016 18.6 6.9 0.002 18.3 6.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Spc24 PF08286.11 PIK61963.1 - 0.018 15.3 9.3 0.087 13.1 9.3 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF1664 PF07889.12 PIK61963.1 - 0.063 13.3 5.5 2.4 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 PIK61963.1 - 0.078 13.4 1.1 0.078 13.4 1.1 2.1 2 0 0 2 2 2 0 Snapin/Pallidin Spectrin PF00435.21 PIK61963.1 - 0.17 12.4 6.5 0.2 12.2 2.2 2.2 2 0 0 2 2 2 0 Spectrin repeat NPV_P10 PF05531.12 PIK61963.1 - 0.18 12.3 8.3 0.097 13.2 1.9 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 PIK61963.1 - 0.19 11.5 11.2 0.62 9.9 0.8 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF2508 PF10704.9 PIK61963.1 - 0.53 10.5 7.7 0.31 11.2 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) FliD_N PF02465.18 PIK61963.1 - 1 10.1 9.8 2.3 9.0 6.6 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus PCRF PF03462.18 PIK61963.1 - 1.4 8.8 7.1 2 8.2 7.1 1.3 1 1 0 1 1 1 0 PCRF domain Fzo_mitofusin PF04799.13 PIK61963.1 - 1.4 8.4 5.2 3.7 7.1 0.2 2.1 2 0 0 2 2 2 0 fzo-like conserved region DUF4140 PF13600.6 PIK61963.1 - 2.5 8.6 8.5 3.1 8.3 3.9 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fungal_TACC PF12709.7 PIK61964.1 - 0.18 12.2 0.2 0.18 12.2 0.2 3.0 2 2 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins WEMBL PF05701.11 PIK61965.1 - 0.00078 18.3 27.0 0.00099 17.9 27.0 1.0 1 0 0 1 1 1 1 Weak chloroplast movement under blue light Fib_alpha PF08702.10 PIK61965.1 - 0.0012 19.0 21.0 0.012 15.8 8.6 3.0 1 1 2 3 3 3 2 Fibrinogen alpha/beta chain family Filament PF00038.21 PIK61965.1 - 0.0024 17.5 31.2 0.0067 16.0 31.2 1.8 1 1 0 1 1 1 1 Intermediate filament protein DUF724 PF05266.14 PIK61965.1 - 0.011 15.6 27.1 0.061 13.2 6.9 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1192 PF06698.11 PIK61965.1 - 0.023 14.7 7.3 15 5.7 0.1 4.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) APG6_N PF17675.1 PIK61965.1 - 0.024 15.2 12.3 0.024 15.2 12.3 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 PIK61965.1 - 0.024 15.6 9.7 0.024 15.6 9.7 3.0 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Bacillus_HBL PF05791.11 PIK61965.1 - 0.05 13.4 18.8 0.026 14.3 3.9 3.1 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) HAP1_N PF04849.13 PIK61965.1 - 0.083 12.1 31.1 0.29 10.3 16.1 2.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Spc7 PF08317.11 PIK61965.1 - 0.086 11.7 31.9 0.99 8.2 20.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein NiFeSe_Hases PF00374.19 PIK61965.1 - 0.1 11.5 1.9 0.1 11.5 0.9 1.4 1 1 0 1 1 1 0 Nickel-dependent hydrogenase Fez1 PF06818.15 PIK61965.1 - 0.11 13.0 30.8 0.18 12.2 4.6 2.5 1 1 1 2 2 2 0 Fez1 KASH_CCD PF14662.6 PIK61965.1 - 0.14 12.0 31.6 0.63 9.8 3.7 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg PF16515.5 PIK61965.1 - 0.19 12.3 34.2 0.51 11.0 7.7 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 PIK61965.1 - 0.29 11.3 34.3 2.3 8.4 17.7 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PTR PF12789.7 PIK61965.1 - 0.39 10.8 6.4 0.24 11.5 1.5 2.8 2 1 1 3 3 3 0 Phage tail repeat like BRE1 PF08647.11 PIK61965.1 - 0.47 10.6 32.0 4.1 7.5 12.8 4.2 2 2 2 4 4 4 0 BRE1 E3 ubiquitin ligase Tup_N PF08581.10 PIK61965.1 - 0.52 10.6 26.1 0.31 11.4 6.9 4.3 1 1 3 4 4 4 0 Tup N-terminal FAM184 PF15665.5 PIK61965.1 - 0.76 9.5 32.9 0.6 9.9 23.4 2.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B KxDL PF10241.9 PIK61965.1 - 0.78 10.1 20.0 2.5 8.4 8.0 2.9 2 2 0 2 2 2 0 Uncharacterized conserved protein TPR_MLP1_2 PF07926.12 PIK61965.1 - 0.85 9.7 31.8 0.54 10.3 18.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 PIK61965.1 - 0.92 9.5 6.8 2.9 7.9 0.8 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus VPS38 PF17649.1 PIK61965.1 - 0.97 8.2 15.5 0.056 12.3 8.4 1.9 1 1 1 2 2 2 0 Vacuolar protein sorting 38 DUF883 PF05957.13 PIK61965.1 - 0.97 10.1 21.4 0.11 13.1 5.1 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) TMPIT PF07851.13 PIK61965.1 - 1 8.5 23.5 0.02 14.1 9.3 2.6 1 1 2 3 3 3 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 PIK61965.1 - 1.5 8.9 38.2 8.2 6.4 22.8 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 PIK61965.1 - 1.5 8.9 19.9 0.76 9.8 3.1 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 PIK61965.1 - 1.9 8.8 24.1 0.29 11.4 2.9 3.8 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) Cnn_1N PF07989.11 PIK61965.1 - 2.3 8.5 25.1 0.18 12.0 4.7 3.8 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 ERM PF00769.19 PIK61965.1 - 3.2 7.5 34.1 0.97 9.2 24.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 PIK61965.1 - 3.6 7.0 33.9 5.3 6.4 19.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF641 PF04859.12 PIK61965.1 - 3.8 7.9 26.2 3.6 7.9 2.8 3.6 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 PIK61965.1 - 4.4 6.3 27.1 0.62 9.1 17.6 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 PIK61965.1 - 4.4 7.4 22.3 27 4.8 1.7 4.0 1 1 2 3 3 3 0 FlxA-like protein CENP-H PF05837.12 PIK61965.1 - 4.6 7.7 29.5 0.81 10.1 11.6 3.3 1 1 3 4 4 3 0 Centromere protein H (CENP-H) DUF2968 PF11180.8 PIK61965.1 - 4.6 6.8 22.0 3.5 7.2 4.6 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF2968) DUF4201 PF13870.6 PIK61965.1 - 5.2 6.8 32.7 1.9 8.2 9.0 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF4472 PF14739.6 PIK61965.1 - 5.8 7.7 27.6 12 6.7 13.9 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) HAUS6_N PF14661.6 PIK61965.1 - 7.3 6.1 22.6 2.9 7.4 9.9 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF948 PF06103.11 PIK61965.1 - 8 6.8 14.6 2.5 8.4 1.4 3.5 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 PIK61965.1 - 8.6 5.7 35.1 0.89 8.9 17.4 2.8 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 PIK61965.1 - 9.6 5.5 19.1 3.2 7.0 10.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HemX PF04375.14 PIK61965.1 - 9.9 5.3 23.3 1.7 7.9 7.2 2.5 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase zf-RING_2 PF13639.6 PIK61966.1 - 2.1e-10 40.8 4.8 2.7e-10 40.4 4.8 1.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 PIK61966.1 - 3.7e-07 29.8 4.6 5.4e-07 29.2 4.6 1.3 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK61966.1 - 1.8e-06 27.7 4.3 2.4e-06 27.3 4.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK61966.1 - 9.9e-05 22.5 4.9 0.00025 21.2 4.9 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 PIK61966.1 - 0.00013 21.9 4.4 0.00017 21.5 4.4 1.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 PIK61966.1 - 0.00072 19.4 4.9 0.00098 18.9 4.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 PIK61966.1 - 0.00082 18.9 2.3 0.0012 18.4 2.3 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 PIK61966.1 - 0.0022 18.1 3.0 0.0043 17.2 3.0 1.5 1 1 0 1 1 1 1 RING-variant domain zf-RING_5 PF14634.6 PIK61966.1 - 0.006 16.5 3.4 0.0076 16.2 3.4 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 PIK61966.1 - 0.0076 16.1 3.0 0.0099 15.7 3.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 PIK61966.1 - 0.025 14.9 2.7 0.035 14.4 2.7 1.2 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 PIK61966.1 - 0.041 14.1 3.1 0.22 11.7 3.7 1.8 1 1 1 2 2 2 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 PIK61966.1 - 0.089 12.7 3.1 0.14 12.1 3.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C2H2 PF00096.26 PIK61967.1 - 0.0024 18.2 17.6 0.08 13.4 1.4 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met2 PF12907.7 PIK61967.1 - 0.047 13.8 5.7 0.89 9.8 0.8 2.5 2 0 0 2 2 2 0 Zinc-binding zf-C2H2_4 PF13894.6 PIK61967.1 - 0.064 14.1 19.9 1.7 9.7 1.6 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 PIK61967.1 - 0.11 13.0 12.3 0.16 12.4 1.6 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type bZIP_1 PF00170.21 PIK61968.1 - 0.044 13.9 2.6 0.078 13.1 0.5 2.6 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 PIK61968.1 - 0.66 10.1 5.5 1.4 9.1 0.6 2.9 2 0 0 2 2 2 0 Basic region leucine zipper Cadherin_C PF01049.17 PIK61969.1 - 2.7e-39 134.8 0.1 4.6e-39 134.0 0.1 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Laminin_G_2 PF02210.24 PIK61969.1 - 1.4e-31 109.7 0.9 9e-15 55.4 0.3 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 PIK61969.1 - 1.3e-24 86.8 0.0 2.9e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.6 PIK61969.1 - 0.015 15.5 2.6 0.17 12.0 0.3 2.8 2 1 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily TMEM154 PF15102.6 PIK61969.1 - 0.16 11.8 0.0 0.4 10.6 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family EGF PF00008.27 PIK61969.1 - 0.24 11.8 20.9 0.042 14.1 4.3 3.4 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 PIK61969.1 - 2.1 9.1 28.4 0.051 14.2 5.0 4.0 4 0 0 4 4 4 0 Human growth factor-like EGF Cadherin PF00028.17 PIK61970.1 - 1.9e-178 579.6 53.9 3.1e-16 59.6 0.5 17.5 17 0 0 17 17 17 16 Cadherin domain Cadherin_3 PF16184.5 PIK61970.1 - 8.7e-10 38.6 22.2 0.01 15.8 0.1 11.1 11 0 0 11 11 11 4 Cadherin-like Cadherin_2 PF08266.12 PIK61970.1 - 7.2e-08 32.2 0.6 1.2 9.0 0.0 7.0 10 0 0 10 10 10 2 Cadherin-like Cadherin_pro PF08758.11 PIK61970.1 - 5.8e-06 26.4 6.4 0.02 15.1 0.0 6.2 8 0 0 8 8 8 2 Cadherin prodomain like RET_CLD1 PF17756.1 PIK61970.1 - 0.039 14.2 0.0 35 4.7 0.0 4.3 3 0 0 3 3 3 0 RET Cadherin like domain 1 PepSY PF03413.19 PIK61970.1 - 0.15 12.6 10.9 36 5.0 0.0 7.2 8 0 0 8 8 8 0 Peptidase propeptide and YPEB domain Not1 PF04054.15 PIK61971.1 - 9.9e-32 110.2 0.6 1.2e-31 110.0 0.6 1.0 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 PIK61972.1 - 7.3e-90 300.3 5.9 7.3e-90 300.3 5.9 2.0 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Not1 PF04054.15 PIK61972.1 - 1e-67 228.7 6.0 2.6e-65 220.8 6.0 2.8 1 1 0 1 1 1 1 CCR4-Not complex component, Not1 DUF3819 PF12842.7 PIK61972.1 - 1.9e-55 186.8 2.4 1.9e-55 186.8 2.4 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT11 PF10155.9 PIK61972.1 - 1.4 9.0 3.7 39 4.4 0.1 3.7 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 CNOT1_TTP_bind PF16417.5 PIK61973.1 - 3.5e-66 222.0 0.1 9.3e-66 220.6 0.1 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 PIK61973.1 - 4.6e-44 150.1 0.2 5.4e-42 143.4 0.0 2.5 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 HEAT repeat HYR PF02494.16 PIK61974.1 - 1.9e-49 165.9 12.0 8.3e-18 64.5 1.1 3.1 3 0 0 3 3 3 3 HYR domain HYR PF02494.16 PIK61975.1 - 4e-217 703.2 138.5 6.4e-18 64.9 2.7 20.2 17 3 3 20 20 20 20 HYR domain EGF PF00008.27 PIK61975.1 - 6.2e-23 80.7 159.1 3.4e-07 30.4 7.3 11.2 12 0 0 12 12 12 7 EGF-like domain hEGF PF12661.7 PIK61975.1 - 3e-10 40.3 112.3 0.0013 19.2 5.2 11.9 9 0 0 9 9 9 7 Human growth factor-like EGF EGF_2 PF07974.13 PIK61975.1 - 0.0095 16.3 10.6 0.0095 16.3 10.6 11.5 11 0 0 11 11 11 6 EGF-like domain HYR PF02494.16 PIK61976.1 - 9.5e-111 362.3 43.4 6.7e-25 87.2 4.0 5.2 5 0 0 5 5 5 5 HYR domain Cadherin_3 PF16184.5 PIK61976.1 - 4.4e-05 23.4 0.6 0.25 11.4 0.0 3.4 4 0 0 4 4 4 2 Cadherin-like DUF5011 PF16403.5 PIK61976.1 - 4.8e-05 23.4 4.8 20 5.4 0.0 5.3 5 0 0 5 5 5 1 Domain of unknown function (DUF5011) PA_decarbox PF05870.11 PIK61976.1 - 0.0037 16.9 3.0 32 4.1 0.1 4.1 4 0 0 4 4 4 0 Phenolic acid decarboxylase (PAD) zf-BED PF02892.15 PIK61976.1 - 1.4 9.0 5.6 20 5.3 0.3 2.6 2 0 0 2 2 2 0 BED zinc finger DUF3138 PF11336.8 PIK61976.1 - 5.7 5.4 8.9 0.12 11.0 0.6 2.2 2 1 0 3 3 3 0 Protein of unknown function (DUF3138) HYR PF02494.16 PIK61977.1 - 5.4e-192 622.7 67.4 8.2e-25 86.9 1.0 11.0 11 0 0 11 11 11 11 HYR domain Cadherin_3 PF16184.5 PIK61977.1 - 0.0011 18.9 12.9 0.51 10.3 0.0 6.3 6 1 0 7 7 7 2 Cadherin-like PA_decarbox PF05870.11 PIK61977.1 - 0.0059 16.3 9.7 67 3.1 0.0 7.5 8 0 0 8 8 8 0 Phenolic acid decarboxylase (PAD) RRM PF10378.9 PIK61977.1 - 0.087 12.6 0.4 0.28 10.9 0.4 1.9 1 0 0 1 1 1 0 Putative RRM domain DUF5011 PF16403.5 PIK61977.1 - 0.19 11.9 6.3 1e+02 3.1 0.0 6.2 7 0 0 7 7 7 0 Domain of unknown function (DUF5011) HYR PF02494.16 PIK61978.1 - 1.6e-49 166.1 7.7 7.9e-24 83.8 0.3 3.1 3 0 0 3 3 3 3 HYR domain DUF1604 PF07713.13 PIK61980.1 - 1.2e-38 130.8 1.4 2.1e-38 130.0 1.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.23 PIK61980.1 - 5.1e-07 29.5 4.2 4.5e-06 26.5 3.2 2.9 2 1 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 PIK61980.1 - 0.002 18.2 2.3 0.0053 16.8 0.4 2.6 3 0 0 3 3 3 1 G-patch domain HYR PF02494.16 PIK61981.1 - 1.5e-47 159.8 16.1 2.9e-21 75.6 1.8 3.1 3 0 0 3 3 3 3 HYR domain AP_endonuc_2_N PF07582.12 PIK61981.1 - 0.022 14.5 0.0 5.3 6.9 0.0 2.3 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus DUF903 PF06004.12 PIK61981.1 - 0.028 14.3 3.7 23 5.0 0.1 4.0 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF903) DUF5011 PF16403.5 PIK61981.1 - 0.04 14.0 0.0 5.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) EB1_binding PF05937.11 PIK61981.1 - 0.31 11.6 3.6 15 6.2 0.3 2.4 2 0 0 2 2 2 0 EB-1 Binding Domain NACHT PF05729.12 PIK61982.1 - 2.8e-09 37.1 0.1 6.1e-09 36.0 0.0 1.5 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 PIK61982.1 - 4.1e-05 24.0 0.1 8e-05 23.1 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 PIK61982.1 - 6.5e-05 22.2 0.1 0.00022 20.5 0.1 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 PIK61982.1 - 0.00013 22.2 0.0 0.00043 20.6 0.0 1.8 1 1 0 2 2 2 1 AAA domain AAA PF00004.29 PIK61982.1 - 0.00093 19.6 0.1 0.0022 18.4 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 PIK61982.1 - 0.0073 16.3 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 PIK61982.1 - 0.01 15.4 0.1 0.021 14.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 PIK61982.1 - 0.024 14.1 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein RuvB_N PF05496.12 PIK61982.1 - 0.029 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 PIK61982.1 - 0.03 14.4 0.1 0.18 11.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 PIK61982.1 - 0.03 14.5 0.0 0.037 14.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 PIK61982.1 - 0.033 14.1 0.1 0.075 12.9 0.1 1.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 PIK61982.1 - 0.039 14.5 0.1 2.2 8.8 0.1 2.2 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 PIK61982.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 PIK61982.1 - 0.079 12.3 0.0 0.33 10.3 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Bac_DnaA PF00308.18 PIK61982.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein MAPEG PF01124.18 PIK61985.1 - 1.6e-23 83.0 0.0 1.9e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 MAPEG family DUF3862 PF12978.7 PIK61985.1 - 0.057 13.2 0.0 0.066 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) DUF2464 PF10240.9 PIK61986.1 - 7.8e-48 163.3 0.0 9.7e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Multivesicular body subunit 12 ISAV_HA PF06215.11 PIK61986.1 - 0.19 10.8 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin CC190 PF15768.5 PIK61987.1 - 0.00018 21.7 4.2 0.00018 21.7 4.2 3.4 2 1 2 4 4 4 2 Coiled-coil domain-containing protein 190 Amidinotransf PF02274.17 PIK61988.1 - 5.3e-09 35.6 0.0 2.6e-08 33.3 0.0 1.9 1 1 0 1 1 1 1 Amidinotransferase Brix PF04427.18 PIK61989.1 - 9.7e-44 149.8 0.6 1.7e-43 148.9 0.6 1.4 1 0 0 1 1 1 1 Brix domain DUF5308 PF17233.2 PIK61989.1 - 0.028 14.6 0.7 0.048 13.9 0.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5308) PPL5 PF18168.1 PIK61989.1 - 0.048 13.0 2.6 0.082 12.2 2.6 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Collagen PF01391.18 PIK61989.1 - 0.048 13.4 8.6 0.13 12.1 8.6 1.7 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) SMN PF06003.12 PIK61989.1 - 0.078 12.2 2.1 0.19 10.9 2.1 1.6 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) CLPTM1 PF05602.12 PIK61989.1 - 0.16 11.0 1.0 0.24 10.4 1.0 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Presenilin PF01080.17 PIK61989.1 - 3.7 6.2 4.9 5 5.8 4.9 1.2 1 0 0 1 1 1 0 Presenilin PBP_sp32 PF07222.12 PIK61989.1 - 4.2 6.7 13.3 6.3 6.2 13.3 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4746 PF15928.5 PIK61989.1 - 5.4 6.3 10.8 9.3 5.6 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Proteasome PF00227.26 PIK61990.1 - 4.4e-35 120.9 0.0 5.1e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Coq4 PF05019.13 PIK61991.1 - 5.7e-44 150.1 0.2 6.6e-44 149.9 0.2 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Sen15 PF09631.10 PIK61992.1 - 4.3e-26 91.1 0.2 5.8e-26 90.7 0.2 1.2 1 0 0 1 1 1 1 Sen15 protein Alpha-amylase PF00128.24 PIK61993.1 - 8.9e-89 298.4 0.2 1.5e-88 297.6 0.2 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Sec1 PF00995.23 PIK61994.1 - 8e-16 58.4 7.8 3.5e-10 39.8 2.9 2.0 2 0 0 2 2 2 2 Sec1 family VGLL4 PF15245.6 PIK61994.1 - 0.22 11.5 1.0 0.44 10.6 0.4 1.8 2 0 0 2 2 2 0 Transcription cofactor vestigial-like protein 4 zf-UBR PF02207.20 PIK61995.1 - 1.6e-07 31.4 15.5 2.3e-07 30.9 14.3 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) UIM PF02809.20 PIK61995.1 - 0.049 13.6 6.6 0.12 12.3 6.6 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif E3_UbLigase_R4 PF13764.6 PIK61996.1 - 9.5e-288 956.8 0.8 8.5e-287 953.7 0.0 2.7 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase UBR4 DUF1512 PF07431.12 PIK61996.1 - 0.023 13.7 0.0 0.092 11.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) Paramyxo_ncap PF00973.19 PIK61996.1 - 0.079 11.9 0.3 0.14 11.0 0.3 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CPL PF08144.11 PIK61996.1 - 0.096 13.0 0.2 0.75 10.1 0.2 2.6 1 0 0 1 1 1 0 CPL (NUC119) domain zinc-ribbons_6 PF07191.12 PIK61996.1 - 1.1 9.3 8.8 7.8 6.6 8.8 2.5 1 0 0 1 1 1 0 zinc-ribbons Cg6151-P PF10233.9 PIK61997.1 - 4.8e-12 46.2 0.7 6.1e-12 45.9 0.7 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P ACBP PF00887.19 PIK61998.1 - 4.8e-26 90.8 0.3 7.9e-26 90.1 0.3 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_2 PF12796.7 PIK61998.1 - 1.3e-12 48.1 0.1 4.3e-06 27.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK61998.1 - 1.4e-12 47.9 0.1 5.4e-11 42.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 PIK61998.1 - 7e-07 29.4 0.0 0.0034 17.8 0.1 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 PIK61998.1 - 9.9e-07 28.6 0.1 0.00086 19.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 PIK61998.1 - 1.3e-06 28.6 0.2 5.7e-06 26.5 0.2 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) zf-C4 PF00105.18 PIK61999.1 - 1.1e-24 86.7 14.9 3e-24 85.3 14.9 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 PIK61999.1 - 6.5e-19 68.3 5.8 1.2e-18 67.4 5.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF4410 PF14366.6 PIK62002.1 - 3.5 7.6 4.9 5.7 6.8 0.7 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4410) Med9 PF07544.13 PIK62004.1 - 0.014 15.5 1.4 0.014 15.5 1.4 12.0 9 4 3 12 12 12 0 RNA polymerase II transcription mediator complex subunit 9 Cnn_1N PF07989.11 PIK62004.1 - 3 8.1 0.0 3 8.1 0.0 15.7 5 3 8 14 14 14 0 Centrosomin N-terminal motif 1 TSP_1 PF00090.19 PIK62005.1 - 1.2e-38 131.0 71.3 9.2e-09 35.4 3.8 9.3 9 0 0 9 9 9 7 Thrombospondin type 1 domain CUB PF00431.20 PIK62005.1 - 3.4e-26 91.7 0.2 9.1e-18 64.6 0.0 4.7 4 1 0 4 4 4 2 CUB domain Reprolysin_5 PF13688.6 PIK62005.1 - 5.1e-12 46.4 1.5 1.3e-11 45.0 0.0 2.5 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin PF01421.19 PIK62005.1 - 1.4e-10 41.4 0.3 1.1e-09 38.5 0.0 2.6 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 PIK62005.1 - 2e-05 25.1 0.0 4.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF1654 PF07867.11 PIK62005.1 - 0.12 12.2 0.2 0.83 9.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) zinc_ribbon_2 PF13240.6 PIK62005.1 - 0.54 10.0 10.5 14 5.5 0.1 6.2 6 0 0 6 6 6 0 zinc-ribbon domain CUB PF00431.20 PIK62006.1 - 1.1e-44 151.3 2.6 3.3e-11 43.5 0.1 5.2 5 0 0 5 5 5 5 CUB domain TSP_1 PF00090.19 PIK62006.1 - 1.9e-16 60.0 29.4 5.3e-08 33.0 4.0 5.0 4 0 0 4 4 4 4 Thrombospondin type 1 domain CUB_2 PF02408.20 PIK62006.1 - 0.00034 20.4 8.5 0.054 13.3 0.0 4.1 5 0 0 5 5 5 2 CUB-like domain zf-FPG_IleRS PF06827.14 PIK62006.1 - 0.023 14.6 0.0 0.023 14.6 0.0 3.7 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS Rad50_zn_hook PF04423.14 PIK62006.1 - 8.4 6.3 8.3 3.3 7.6 0.1 2.8 3 0 0 3 3 3 0 Rad50 zinc hook motif TSP_1 PF00090.19 PIK62007.1 - 0.002 18.3 1.3 0.0029 17.8 0.1 1.9 2 0 0 2 2 2 1 Thrombospondin type 1 domain SnoaL PF07366.12 PIK62007.1 - 0.052 13.3 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase CUB PF00431.20 PIK62008.1 - 5.9e-49 165.0 0.1 2.5e-15 56.8 0.1 5.8 5 0 0 5 5 5 5 CUB domain TSP_1 PF00090.19 PIK62008.1 - 3.7e-29 100.7 75.2 3.7e-05 23.9 2.2 9.4 9 0 0 9 9 9 8 Thrombospondin type 1 domain FMO-like PF00743.19 PIK62009.1 - 4.7e-185 616.0 0.1 5.2e-185 615.9 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK62009.1 - 6.1e-18 65.1 0.2 2.7e-14 53.1 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK62009.1 - 1.3e-13 50.9 0.0 7.1e-13 48.4 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK62009.1 - 8.5e-09 35.0 0.3 9.1e-06 25.0 0.0 3.5 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK62009.1 - 0.00013 22.2 0.0 0.00029 21.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK62009.1 - 0.00052 19.7 0.1 0.11 12.1 0.0 3.2 3 1 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK62009.1 - 0.0016 19.0 0.1 0.077 13.6 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK62009.1 - 0.0078 15.5 0.0 0.42 9.8 0.0 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_9 PF13454.6 PIK62009.1 - 0.015 15.3 0.4 1.9 8.5 0.0 3.6 3 1 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 PIK62009.1 - 0.032 13.3 0.0 0.065 12.3 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 PIK62009.1 - 0.19 10.4 0.9 0.39 9.4 0.3 1.8 2 0 0 2 2 2 0 HI0933-like protein FMO-like PF00743.19 PIK62010.1 - 1.2e-185 617.9 0.0 1.4e-185 617.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 PIK62010.1 - 2.3e-18 66.5 0.1 4e-14 52.6 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 PIK62010.1 - 5.9e-14 52.0 0.0 2.2e-13 50.1 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 PIK62010.1 - 4.5e-09 35.9 0.2 4.9e-06 25.9 0.0 3.4 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 PIK62010.1 - 0.00014 22.0 0.0 0.0003 20.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 PIK62010.1 - 0.00038 20.1 0.1 0.051 13.2 0.0 3.1 3 1 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 PIK62010.1 - 0.002 18.7 0.1 0.14 12.8 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 PIK62010.1 - 0.01 15.1 0.0 0.42 9.8 0.0 2.4 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.6 PIK62010.1 - 0.018 15.1 0.3 1.8 8.5 0.0 3.5 3 1 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 PIK62010.1 - 0.029 13.5 0.1 0.06 12.4 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 PIK62010.1 - 0.25 10.0 0.9 0.39 9.4 0.3 1.6 2 0 0 2 2 2 0 HI0933-like protein zf-U1 PF06220.12 PIK62011.1 - 6.9 6.5 5.9 24 4.8 0.1 4.1 3 1 1 4 4 4 0 U1 zinc finger Nuc_deoxyri_tr2 PF15891.5 PIK62016.1 - 4.6e-19 68.7 0.0 9.5e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like EF-hand_6 PF13405.6 PIK62016.1 - 0.02 14.8 0.6 0.25 11.4 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain DUF3945 PF13101.6 PIK62016.1 - 0.097 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) Nuc_deoxyri_tr2 PF15891.5 PIK62017.1 - 7.6e-10 39.1 0.0 1.9e-09 37.8 0.0 1.7 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase like GcnA_N PF18229.1 PIK62017.1 - 0.052 13.6 0.4 0.14 12.2 0.1 1.8 2 0 0 2 2 2 0 N-acetyl-beta-D-glucosaminidase N-terminal domain CI-B14_5a PF07347.12 PIK62017.1 - 0.094 12.6 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) DUF4481 PF14800.6 PIK62018.1 - 6.3e-23 81.7 2.9 2.5e-17 63.3 1.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4481) TIR_2 PF13676.6 PIK62018.1 - 1.9e-08 34.9 0.0 4.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 PIK62018.1 - 3.3e-08 33.5 0.0 9.7e-08 32.0 0.0 1.7 2 0 0 2 2 2 1 TIR domain FAS_I_H PF18314.1 PIK62018.1 - 0.22 11.1 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain Ctr PF04145.15 PIK62020.1 - 1.3e-36 126.5 8.1 1.6e-36 126.1 8.1 1.1 1 0 0 1 1 1 1 Ctr copper transporter family SecG PF03840.14 PIK62020.1 - 0.1 12.7 0.4 0.1 12.7 0.4 1.9 2 0 0 2 2 2 0 Preprotein translocase SecG subunit FtsJ PF01728.19 PIK62021.1 - 7e-18 65.4 0.5 5.8e-11 42.8 0.0 2.8 3 1 0 3 3 3 2 FtsJ-like methyltransferase Med27 PF11571.8 PIK62022.1 - 1.7e-26 92.4 1.9 2.7e-26 91.7 0.2 2.1 3 0 0 3 3 3 1 Mediator complex subunit 27 Glyco_transf_25 PF01755.17 PIK62023.1 - 4.2e-14 52.9 0.3 4e-06 26.8 0.3 3.2 2 1 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) GST_N_3 PF13417.6 PIK62024.1 - 1.1e-09 38.5 0.0 2.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 PIK62024.1 - 4.9e-08 33.1 0.6 1.3e-07 31.7 0.6 1.7 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 PIK62024.1 - 1.7e-05 25.0 0.0 3.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 PIK62024.1 - 0.0088 16.8 0.0 0.019 15.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 PIK62024.1 - 0.021 14.9 0.0 0.065 13.3 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 PIK62024.1 - 0.023 15.0 0.0 0.076 13.4 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 PIK62024.1 - 0.039 13.7 0.0 1 9.2 0.0 2.8 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain PLDc_N PF13396.6 PIK62025.1 - 0.0001 22.2 0.1 0.00019 21.3 0.1 1.4 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF2737 PF10930.8 PIK62025.1 - 1.2 8.7 7.4 78 3.0 0.1 4.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2737) LAP1C PF05609.12 PIK62026.1 - 1.8e-23 83.4 1.7 2.2e-23 83.1 1.7 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) HapK PF11639.8 PIK62026.1 - 0.035 14.6 0.0 0.085 13.4 0.0 1.6 1 0 0 1 1 1 0 REDY-like protein HapK CDC45 PF02724.14 PIK62026.1 - 0.11 10.7 7.7 0.16 10.2 7.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 PIK62026.1 - 0.69 8.6 5.9 1.1 8.0 5.9 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 PIK62026.1 - 1.9 7.6 5.1 2.6 7.2 5.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 PIK62026.1 - 2.7 7.8 12.2 4.7 7.0 12.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 PIK62026.1 - 4 6.9 5.5 7.5 6.0 5.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 zf-FCS PF06467.14 PIK62027.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif TLC PF03219.14 PIK62027.1 - 2.5 6.7 4.6 2.3 6.8 1.9 1.8 2 0 0 2 2 2 0 TLC ATP/ADP transporter VWD PF00094.25 PIK62028.1 - 6.9e-28 97.9 0.3 1.1e-27 97.3 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Ldl_recept_a PF00057.18 PIK62028.1 - 1.8e-10 40.8 10.3 2.4e-08 34.0 5.5 4.7 2 2 1 4 4 4 2 Low-density lipoprotein receptor domain class A EGF_3 PF12947.7 PIK62028.1 - 3.7 7.8 31.4 0.039 14.2 9.9 4.6 3 0 0 3 3 3 0 EGF domain NIDO PF06119.14 PIK62029.1 - 5.9e-14 52.8 0.9 9.9e-14 52.1 0.9 1.4 1 0 0 1 1 1 1 Nidogen-like AMOP PF03782.17 PIK62029.1 - 2.4e-08 34.2 1.7 2.5e-07 30.9 1.7 2.0 1 1 0 1 1 1 1 AMOP domain VWD PF00094.25 PIK62030.1 - 3.1e-10 40.5 0.0 4.6e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Mucin PF01456.17 PIK62032.1 - 0.00017 21.6 23.7 0.00026 21.0 5.0 2.5 2 0 0 2 2 2 2 Mucin-like glycoprotein EGF PF00008.27 PIK62032.1 - 0.00063 20.0 7.9 0.00063 20.0 7.9 2.1 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 PIK62032.1 - 0.0014 19.2 3.4 0.0014 19.2 3.4 2.4 2 0 0 2 2 2 1 Human growth factor-like EGF EGF_CA PF07645.15 PIK62032.1 - 0.0024 18.0 5.2 0.0049 17.0 5.2 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.7 PIK62032.1 - 0.04 13.8 1.7 0.04 13.8 1.7 2.7 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK62032.1 - 0.044 14.0 6.1 0.14 12.4 6.1 1.9 1 0 0 1 1 1 0 EGF domain VWD PF00094.25 PIK62033.1 - 1.6e-33 116.2 0.1 5.5e-33 114.5 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type D domain CPT_N PF16484.5 PIK62033.1 - 0.03 14.3 0.0 0.089 12.8 0.0 1.8 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus C8 PF08742.11 PIK62034.1 - 8.4e-12 45.3 1.1 8.4e-12 45.3 1.1 3.5 3 1 1 4 4 4 1 C8 domain TIL PF01826.17 PIK62034.1 - 1.6e-07 31.5 9.3 1.6e-07 31.5 9.3 4.7 3 2 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Ldl_recept_a PF00057.18 PIK62034.1 - 4.7e-07 29.9 10.0 4.7e-07 29.9 10.0 4.3 5 1 0 5 5 5 1 Low-density lipoprotein receptor domain class A EGF_3 PF12947.7 PIK62034.1 - 0.044 14.0 9.8 0.044 14.0 9.8 5.4 7 1 1 8 8 8 0 EGF domain EGF_CA PF07645.15 PIK62035.1 - 2.1e-21 75.9 48.2 1.1e-07 31.9 12.0 3.2 3 0 0 3 3 3 3 Calcium-binding EGF domain cEGF PF12662.7 PIK62035.1 - 1.6e-15 56.7 25.4 6e-08 32.5 3.2 4.2 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_3 PF12947.7 PIK62035.1 - 4.3e-08 33.2 45.9 1.9e-05 24.7 14.3 3.4 3 0 0 3 3 3 3 EGF domain FXa_inhibition PF14670.6 PIK62035.1 - 3.4e-07 30.4 43.3 0.00064 19.9 7.1 3.4 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK62035.1 - 3.8e-05 23.9 39.2 0.019 15.3 7.2 3.9 3 1 0 3 3 3 3 EGF-like domain hEGF PF12661.7 PIK62035.1 - 0.0012 19.4 2.4 0.0012 19.4 2.4 4.3 4 0 0 4 4 4 2 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 PIK62035.1 - 1.5 8.9 28.7 0.18 11.9 6.8 3.4 3 0 0 3 3 3 0 MSP1 EGF domain 1 DUF4711 PF15829.5 PIK62036.1 - 0.0004 20.4 0.5 0.00099 19.1 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4711) TMIE PF16038.5 PIK62036.1 - 0.0057 16.5 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 TMIE protein Smim3 PF17307.2 PIK62036.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Small integral membrane protein 3 FXa_inhibition PF14670.6 PIK62037.1 - 3.5e-07 30.4 11.5 3.5e-07 30.4 11.5 4.2 6 0 0 6 6 6 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 PIK62037.1 - 1.8e-06 28.0 11.3 1.8e-06 28.0 11.3 4.3 5 1 1 6 6 6 1 Calcium-binding EGF domain cEGF PF12662.7 PIK62037.1 - 0.00086 19.2 3.1 0.00086 19.2 3.1 4.1 4 1 0 4 4 4 2 Complement Clr-like EGF-like EMI PF07546.13 PIK62037.1 - 0.0014 19.4 19.7 0.0014 19.4 19.7 4.2 3 2 0 3 3 3 1 EMI domain EGF PF00008.27 PIK62037.1 - 0.029 14.7 8.4 0.029 14.7 8.4 3.8 3 1 0 3 3 3 0 EGF-like domain SlyX PF04102.12 PIK62037.1 - 0.39 11.4 3.1 0.42 11.2 1.3 1.8 2 0 0 2 2 2 0 SlyX FKBP_C PF00254.28 PIK62039.1 - 3.1e-29 101.1 0.0 8.6e-29 99.7 0.0 1.8 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WH1 PF00568.23 PIK62039.1 - 0.002 18.1 0.1 0.0041 17.0 0.1 1.5 1 0 0 1 1 1 1 WH1 domain Hydantoinase_A PF01968.18 PIK62039.1 - 0.17 11.1 0.7 0.36 10.0 0.7 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Sas6_CC PF18594.1 PIK62039.1 - 2.3 8.1 9.0 5.1 7.0 0.0 4.1 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain Myb_DNA-binding PF00249.31 PIK62040.1 - 8.5e-08 32.3 0.1 2e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 PIK62040.1 - 0.0054 16.9 2.1 0.0078 16.4 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain EGF PF00008.27 PIK62041.1 - 2e-159 517.1 412.5 5e-09 36.3 10.4 29.4 28 1 1 29 29 29 28 EGF-like domain hEGF PF12661.7 PIK62041.1 - 2.1e-102 332.7 341.0 2.4e-07 31.1 9.1 30.3 29 0 0 29 29 29 27 Human growth factor-like EGF EGF_CA PF07645.15 PIK62041.1 - 4.9e-48 161.1 404.9 0.00028 21.0 7.1 28.3 18 6 10 28 28 28 23 Calcium-binding EGF domain EGF_2 PF07974.13 PIK62041.1 - 8.7e-32 109.2 456.5 0.0015 18.9 12.0 27.8 26 2 1 27 27 27 20 EGF-like domain EGF_3 PF12947.7 PIK62041.1 - 0.0026 17.9 358.9 0.14 12.3 4.2 28.3 21 5 6 27 27 27 16 EGF domain cEGF PF12662.7 PIK62041.1 - 0.023 14.6 0.7 0.023 14.6 0.7 28.9 26 1 1 27 27 27 0 Complement Clr-like EGF-like DUF2556 PF10831.8 PIK62042.1 - 0.0047 16.8 2.4 17 5.4 0.0 4.1 2 1 2 4 4 4 1 Protein of unknown function (DUF2556) PHD_2 PF13831.6 PIK62042.1 - 0.52 9.9 12.2 1.8 8.2 1.9 2.8 2 0 0 2 2 2 0 PHD-finger RNHCP PF12647.7 PIK62042.1 - 0.79 9.7 8.6 0.14 12.1 3.0 2.5 2 1 0 2 2 2 0 RNHCP domain Spp-24 PF07448.11 PIK62042.1 - 1 9.6 10.1 3.2 8.0 0.6 3.2 2 1 1 3 3 3 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Arginosuc_synth PF00764.19 PIK62043.1 - 3.9e-155 516.9 0.0 4.5e-155 516.7 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 PIK62043.1 - 0.00042 19.9 0.0 0.00064 19.3 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 PIK62043.1 - 0.13 11.1 0.0 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase PDZ_6 PF17820.1 PIK62044.1 - 4.6e-17 61.6 0.1 3.3e-07 30.0 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 PIK62044.1 - 6.6e-14 52.0 0.0 1.4e-05 25.4 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 PIK62044.1 - 8.5e-10 38.8 0.0 0.0017 18.6 0.0 2.7 2 0 0 2 2 2 2 PDZ domain C2 PF00168.30 PIK62044.1 - 1.7e-07 31.5 0.4 4e-07 30.3 0.4 1.7 1 0 0 1 1 1 1 C2 domain PH_16 PF17838.1 PIK62044.1 - 0.096 12.5 0.3 4.9 7.0 0.2 2.6 2 0 0 2 2 2 0 PH domain RGS PF00615.19 PIK62045.1 - 5.4e-35 120.2 1.2 5.4e-35 120.2 1.2 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain Mit_KHE1 PF10173.9 PIK62045.1 - 0.013 15.6 1.0 0.033 14.3 1.0 1.6 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related ThrE PF06738.12 PIK62045.1 - 0.34 10.2 0.1 0.53 9.6 0.1 1.2 1 0 0 1 1 1 0 Putative threonine/serine exporter Arm PF00514.23 PIK62046.1 - 3.8e-06 26.7 0.2 0.051 13.6 0.0 3.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat LRR_8 PF13855.6 PIK62046.1 - 8.2e-05 22.3 2.5 0.031 14.0 0.2 3.2 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK62046.1 - 0.0033 17.8 10.0 0.12 12.9 0.8 3.7 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 PIK62046.1 - 0.11 13.2 6.2 1.7 9.5 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat RVT_3 PF13456.6 PIK62046.1 - 0.12 12.2 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like HEAT_EZ PF13513.6 PIK62046.1 - 0.16 12.5 0.0 2.1 9.0 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat LRR_6 PF13516.6 PIK62046.1 - 1.2 9.4 6.7 1 9.6 0.2 3.7 4 0 0 4 4 4 0 Leucine Rich repeat Ribosomal_S7 PF00177.21 PIK62047.1 - 1.2e-36 125.6 0.7 1.5e-36 125.2 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e EamA PF00892.20 PIK62048.1 - 1.3e-22 80.4 31.4 2.7e-15 56.8 10.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 PIK62048.1 - 2e-06 27.3 2.3 2e-06 27.3 2.3 2.1 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 PIK62049.1 - 3.6e-08 33.7 19.9 4.3e-08 33.4 19.9 1.1 1 0 0 1 1 1 1 EamA-like transporter family MerC PF03203.14 PIK62049.1 - 0.046 14.2 12.6 0.07 13.6 12.6 1.2 1 0 0 1 1 1 0 MerC mercury resistance protein SieB PF14163.6 PIK62049.1 - 1.1 8.7 5.8 2.6 7.5 0.2 2.2 2 0 0 2 2 2 0 Super-infection exclusion protein B Saf_2TM PF18303.1 PIK62049.1 - 1.2 8.7 7.6 0.81 9.3 4.0 2.4 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain MFS_1 PF07690.16 PIK62050.1 - 0.0056 15.6 24.3 0.25 10.3 25.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily EamA PF00892.20 PIK62051.1 - 6.5e-25 87.9 37.0 1.3e-15 57.7 8.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 PIK62051.1 - 5.1e-05 22.6 5.2 5.1e-05 22.6 5.2 2.3 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport COBRA1 PF06209.13 PIK62052.1 - 1.8e-182 607.4 3.5 2.5e-182 607.0 3.5 1.2 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) FbpA PF05833.11 PIK62052.1 - 0.041 12.6 0.3 0.064 12.0 0.3 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Miga PF10265.9 PIK62053.1 - 3.8e-12 46.0 0.0 4.5e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Mitoguardin CD34_antigen PF06365.12 PIK62053.1 - 0.024 14.2 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family EphA2_TM PF14575.6 PIK62053.1 - 0.069 14.0 0.1 0.11 13.4 0.1 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain WDCP PF15390.6 PIK62053.1 - 0.2 10.0 0.2 0.24 9.8 0.2 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SPX PF03105.19 PIK62053.1 - 1.2 9.0 7.0 1.4 8.8 7.0 1.1 1 0 0 1 1 1 0 SPX domain Miga PF10265.9 PIK62054.1 - 2.8e-76 257.6 2.3 1.1e-45 156.7 0.0 2.0 1 1 1 2 2 2 2 Mitoguardin Suppressor_APC PF11414.8 PIK62055.1 - 4.3e-17 62.0 6.0 4.3e-17 62.0 6.0 3.0 3 0 0 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein EF-hand_6 PF13405.6 PIK62055.1 - 0.0074 16.1 0.1 0.038 13.9 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain OB_RNB PF08206.11 PIK62055.1 - 0.065 12.9 0.1 7.1 6.4 0.0 2.8 2 0 0 2 2 2 0 Ribonuclease B OB domain EF-hand_1 PF00036.32 PIK62055.1 - 0.11 12.1 0.0 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 PIK62055.1 - 0.19 12.2 0.2 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair V_ATPase_I PF01496.19 PIK62055.1 - 0.21 9.5 2.1 0.47 8.3 2.1 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cep57_CLD_2 PF14197.6 PIK62055.1 - 0.23 11.6 4.3 0.15 12.2 0.5 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 BNR_2 PF13088.6 PIK62056.1 - 8.1e-30 104.1 0.0 1.1e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK62056.1 - 4.8e-07 28.8 6.2 0.33 11.1 0.1 4.6 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_3 PF13859.6 PIK62056.1 - 6.2e-05 22.4 0.0 9.2e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain SNF PF00209.18 PIK62057.1 - 6.5e-138 460.7 19.6 9e-124 414.0 10.1 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family AA_permease_2 PF13520.6 PIK62057.1 - 0.0001 21.3 2.5 0.0001 21.3 2.5 2.3 1 1 0 2 2 2 1 Amino acid permease DUF3311 PF11755.8 PIK62057.1 - 0.0046 16.9 11.0 0.0069 16.3 5.0 3.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3311) GNVR PF13807.6 PIK62057.1 - 0.096 12.6 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Ribosomal_L7Ae PF01248.26 PIK62058.1 - 1.3e-21 76.1 0.1 3.1e-21 74.9 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Lipase PF00151.19 PIK62059.1 - 3.9e-70 236.8 2.4 6e-70 236.2 2.4 1.3 1 0 0 1 1 1 1 Lipase Lipase PF00151.19 PIK62060.1 - 1.5e-65 221.7 3.1 2.5e-65 221.0 3.1 1.3 1 1 0 1 1 1 1 Lipase Thioesterase PF00975.20 PIK62060.1 - 0.054 13.6 0.0 0.085 13.0 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain ALAD PF00490.21 PIK62061.1 - 4.5e-125 417.0 0.0 5.4e-125 416.8 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase zf-RING_2 PF13639.6 PIK62062.1 - 5e-10 39.6 7.4 5e-10 39.6 7.4 2.5 4 0 0 4 4 4 1 Ring finger domain zf-RING_11 PF17123.5 PIK62062.1 - 3.7e-09 36.2 3.7 8.1e-09 35.1 3.7 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 PIK62062.1 - 5.2e-06 26.2 7.2 5.2e-06 26.2 7.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 PIK62062.1 - 7.6e-05 22.9 4.0 7.6e-05 22.9 4.0 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK62062.1 - 9.8e-05 22.2 6.5 9.8e-05 22.2 6.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK62062.1 - 0.00043 20.2 5.2 0.00043 20.2 5.2 2.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 PIK62062.1 - 0.0055 16.7 8.2 0.0055 16.7 8.2 2.3 3 0 0 3 3 3 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 PIK62062.1 - 0.0055 16.3 4.1 0.014 15.0 4.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 PIK62062.1 - 1.3 8.9 5.9 4.6 7.2 5.8 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Band_7 PF01145.25 PIK62063.1 - 3.1e-20 72.9 1.3 4.2e-20 72.5 1.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 PIK62063.1 - 0.0015 18.3 0.1 0.0019 18.0 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 PIK62063.1 - 0.051 14.0 0.1 0.091 13.2 0.1 1.6 1 0 0 1 1 1 0 Phage protein Gp68 PGDYG PF14083.6 PIK62063.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 PGDYG protein Band_7 PF01145.25 PIK62064.1 - 6.6e-31 107.7 0.4 8.2e-31 107.4 0.4 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 PIK62064.1 - 0.0032 17.2 0.1 0.0049 16.6 0.1 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 PIK62064.1 - 0.098 13.1 0.2 0.22 12.0 0.2 1.6 1 0 0 1 1 1 0 Phage protein Gp68 Peptidase_M2 PF01401.18 PIK62065.1 - 6.5e-53 180.2 1.3 8.4e-53 179.9 1.3 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme Aminotran_5 PF00266.19 PIK62065.1 - 1.4e-15 57.1 0.0 2.1e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 PIK62065.1 - 6e-05 21.7 0.0 9.3e-05 21.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 PIK62065.1 - 0.13 11.6 0.1 0.27 10.5 0.1 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3567 PF12091.8 PIK62065.1 - 0.14 12.3 0.7 0.87 9.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3567) Peptidase_M2 PF01401.18 PIK62066.1 - 2e-141 472.5 1.2 2.2e-141 472.3 1.2 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Peptidase_M3 PF01432.20 PIK62066.1 - 0.0071 15.7 0.1 0.01 15.2 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M3 Ax_dynein_light PF10211.9 PIK62067.1 - 1.8e-12 47.6 11.4 1.8e-12 47.6 11.4 3.8 4 0 0 4 4 4 2 Axonemal dynein light chain PspA_IM30 PF04012.12 PIK62067.1 - 0.013 15.1 25.4 0.79 9.3 8.9 3.5 3 0 0 3 3 3 0 PspA/IM30 family PRP38 PF03371.15 PIK62068.1 - 5.8e-54 182.6 0.0 7.9e-54 182.1 0.0 1.2 1 0 0 1 1 1 1 PRP38 family SNF PF00209.18 PIK62069.1 - 2.5e-198 660.0 34.8 2.1e-137 459.0 18.6 2.0 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family ABC_tran PF00005.27 PIK62070.1 - 4.3e-30 105.0 0.0 1e-29 103.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK62070.1 - 4.7e-14 52.7 0.5 7e-14 52.1 0.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK62070.1 - 1.9e-08 34.0 0.3 0.00019 20.9 0.1 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 PIK62070.1 - 0.00082 19.3 0.0 0.06 13.2 0.1 2.5 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 PIK62070.1 - 0.00086 19.4 0.1 0.002 18.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 PIK62070.1 - 0.0057 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 PIK62070.1 - 0.032 14.6 1.7 0.04 14.3 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 PIK62070.1 - 0.037 14.1 1.2 0.073 13.2 0.1 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_23 PF13476.6 PIK62070.1 - 0.072 13.6 0.0 0.072 13.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 PIK62070.1 - 0.085 12.6 0.1 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein MeaB PF03308.16 PIK62070.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 PIK62070.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 PIK62070.1 - 0.13 12.6 0.0 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_membrane PF00664.23 PIK62071.1 - 2.2e-31 109.5 10.1 5.8e-30 104.9 8.0 2.3 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 PIK62071.1 - 3.3e-27 95.7 0.0 6.1e-15 55.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 PIK62071.1 - 2.7e-08 33.9 0.3 0.00045 20.2 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 PIK62071.1 - 1.6e-06 28.2 0.8 0.0035 17.4 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 PIK62071.1 - 2.4e-06 27.2 0.5 0.046 13.5 0.0 2.7 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 PIK62071.1 - 6.1e-06 26.9 0.2 0.19 12.2 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 PIK62071.1 - 7.5e-06 26.4 0.2 0.097 13.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 PIK62071.1 - 5.3e-05 22.8 0.5 0.18 11.2 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 PIK62071.1 - 8.8e-05 22.8 0.0 0.24 11.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 PIK62071.1 - 8.9e-05 22.4 0.4 0.21 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 PIK62071.1 - 0.00034 20.2 0.2 0.43 10.1 0.1 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF87 PF01935.17 PIK62071.1 - 0.0018 18.4 0.8 0.21 11.7 0.0 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_15 PF13175.6 PIK62071.1 - 0.0031 17.3 0.6 0.6 9.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 PIK62071.1 - 0.0033 17.5 0.9 2.6 8.1 0.1 2.5 2 0 0 2 2 2 2 Dynamin family RNA_helicase PF00910.22 PIK62071.1 - 0.0035 17.7 0.2 0.34 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 PIK62071.1 - 0.0072 15.5 0.2 1.3 8.2 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 PIK62071.1 - 0.008 16.6 0.0 0.77 10.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 PIK62071.1 - 0.0084 15.8 0.0 3.2 7.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK62071.1 - 0.012 15.6 0.8 0.33 10.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 PIK62071.1 - 0.015 15.1 0.1 3.7 7.3 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Roc PF08477.13 PIK62071.1 - 0.024 14.9 0.1 4.4 7.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 PIK62071.1 - 0.057 12.6 0.3 2.2 7.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 PIK62071.1 - 0.06 13.2 0.2 0.41 10.5 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 PIK62071.1 - 0.063 12.5 0.2 6.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_PrkA PF08298.11 PIK62071.1 - 0.069 12.0 0.2 3.5 6.5 0.1 2.3 2 0 0 2 2 2 0 PrkA AAA domain TsaE PF02367.17 PIK62071.1 - 0.093 12.7 0.0 3.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Adeno_IVa2 PF02456.15 PIK62071.1 - 0.098 11.4 0.2 9.8 4.8 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein ATP-synt_ab PF00006.25 PIK62071.1 - 0.12 12.0 0.1 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 PIK62071.1 - 0.14 11.5 0.2 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.6 PIK62071.1 - 0.15 12.2 0.1 8.4 6.6 0.1 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 PIK62071.1 - 0.17 11.5 5.0 2.1 7.9 0.1 3.0 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain Mfa_like_2 PF15415.6 PIK62071.1 - 0.17 10.7 0.0 0.3 10.0 0.0 1.3 1 0 0 1 1 1 0 Fimbrillin-like MeaB PF03308.16 PIK62071.1 - 0.19 10.7 0.1 0.76 8.7 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TYW3 PF02676.14 PIK62072.1 - 4.3e-46 157.0 0.3 8e-46 156.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase TYW3 DUF2574 PF10836.8 PIK62072.1 - 0.051 13.5 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2574) WAP PF00095.21 PIK62073.1 - 6.1e-09 36.1 12.9 6.1e-09 36.1 12.9 3.0 2 1 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Kazal_2 PF07648.15 PIK62073.1 - 5.5e-07 29.6 5.0 5.5e-07 29.6 5.0 2.5 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Kunitz_BPTI PF00014.23 PIK62074.1 - 7e-33 112.6 22.7 1.1e-16 60.7 7.9 2.6 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Ig_3 PF13927.6 PIK62074.1 - 4e-06 27.3 0.0 1.3e-05 25.6 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain NTR PF01759.21 PIK62074.1 - 2.2e-05 24.2 0.0 4.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module ig PF00047.25 PIK62074.1 - 0.00015 21.8 0.0 0.0004 20.5 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 PIK62074.1 - 0.00037 20.5 0.0 0.00093 19.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_6 PF18452.1 PIK62074.1 - 0.0074 15.8 0.0 0.022 14.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain IL17 PF06083.11 PIK62075.1 - 6e-09 36.3 2.5 6e-09 36.3 2.5 2.0 2 1 0 2 2 2 1 Interleukin-17 DAP_B PF07930.12 PIK62075.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 D-aminopeptidase, domain B RT_RNaseH_2 PF17919.1 PIK62076.1 - 4.4e-37 126.1 0.1 9.2e-37 125.1 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62076.1 - 2e-33 114.8 0.1 5e-33 113.5 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62076.1 - 7.9e-31 107.3 0.0 1.3e-30 106.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK62076.1 - 3.8e-23 82.0 0.1 1.2e-22 80.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62076.1 - 1.6e-17 63.4 1.0 1.6e-17 63.4 1.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK62076.1 - 0.0016 18.6 3.5 0.0049 17.1 0.6 3.2 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 PIK62076.1 - 0.018 14.8 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MycE_N PF17843.1 PIK62076.1 - 0.084 13.4 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal CH PF00307.31 PIK62077.1 - 4.4e-14 52.6 0.2 7.6e-14 51.8 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 PIK62077.1 - 0.041 14.0 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 CH-like domain in sperm protein AAA_22 PF13401.6 PIK62080.1 - 5.8e-07 29.9 3.8 1.2e-05 25.6 0.3 3.4 3 1 0 3 3 2 1 AAA domain AAA PF00004.29 PIK62080.1 - 1.2e-06 28.9 0.0 5.2e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 PIK62080.1 - 1.2e-05 25.7 0.2 0.016 15.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 PIK62080.1 - 4.6e-05 24.0 0.1 0.00041 20.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 PIK62080.1 - 5.6e-05 23.5 0.0 0.00017 21.9 0.0 1.9 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 PIK62080.1 - 7.9e-05 22.5 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 PIK62080.1 - 8.3e-05 22.6 0.0 0.00021 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 PIK62080.1 - 0.00012 22.1 0.0 0.00032 20.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 PIK62080.1 - 0.00013 21.6 0.0 0.0016 18.1 0.0 2.3 1 1 1 2 2 2 1 AAA domain PhoH PF02562.16 PIK62080.1 - 0.00015 21.3 0.0 0.00036 20.0 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.6 PIK62080.1 - 0.00028 21.2 0.0 0.00067 20.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 PIK62080.1 - 0.0007 19.8 0.2 0.0076 16.4 0.0 2.6 3 0 0 3 3 2 1 AAA domain ResIII PF04851.15 PIK62080.1 - 0.0038 17.2 0.1 0.21 11.6 0.0 2.7 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 PIK62080.1 - 0.0043 17.0 0.1 0.017 15.0 0.0 2.0 2 0 0 2 2 1 1 RsgA GTPase NACHT PF05729.12 PIK62080.1 - 0.0059 16.5 0.0 0.015 15.2 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 PIK62080.1 - 0.0073 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 PIK62080.1 - 0.0087 15.6 2.9 0.015 14.8 0.0 2.6 3 1 1 4 4 3 1 P-loop containing dynein motor region AAA_28 PF13521.6 PIK62080.1 - 0.018 15.3 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 PIK62080.1 - 0.021 14.2 0.0 0.048 13.0 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 PIK62080.1 - 0.021 14.5 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 PIK62080.1 - 0.031 14.8 2.2 0.19 12.2 0.0 2.8 2 1 0 2 2 2 0 ABC transporter T2SSE PF00437.20 PIK62080.1 - 0.034 13.2 0.0 0.065 12.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein CENP-F_leu_zip PF10473.9 PIK62080.1 - 0.044 13.8 7.5 0.53 10.3 1.1 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DEAD PF00270.29 PIK62080.1 - 0.045 13.5 0.4 0.17 11.6 0.0 2.2 3 1 0 3 3 1 0 DEAD/DEAH box helicase Torsin PF06309.11 PIK62080.1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Torsin SRP54 PF00448.22 PIK62080.1 - 0.054 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Roc PF08477.13 PIK62080.1 - 0.056 13.7 0.1 0.32 11.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase EMC3_TMCO1 PF01956.16 PIK62080.1 - 0.062 13.0 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like AAA_30 PF13604.6 PIK62080.1 - 0.064 13.0 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 PIK62080.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 PIK62080.1 - 0.14 12.2 0.1 0.4 10.7 0.0 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF4201 PF13870.6 PIK62080.1 - 0.24 11.1 10.5 0.2 11.4 0.3 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4201) SPATA1_C PF15743.5 PIK62080.1 - 0.28 11.3 8.3 0.39 10.8 3.6 2.4 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus Filament PF00038.21 PIK62080.1 - 0.57 9.7 5.3 10 5.6 0.1 2.6 3 0 0 3 3 2 0 Intermediate filament protein PspA_IM30 PF04012.12 PIK62080.1 - 0.63 9.6 6.1 2.7 7.5 0.6 2.3 2 0 0 2 2 2 0 PspA/IM30 family Sec2p PF06428.11 PIK62080.1 - 0.68 9.9 7.4 1.8 8.6 1.2 2.8 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF812 PF05667.11 PIK62080.1 - 0.76 8.6 7.8 0.4 9.5 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Prefoldin_2 PF01920.20 PIK62080.1 - 4.8 7.2 10.1 4 7.4 0.7 3.1 2 1 1 3 3 3 0 Prefoldin subunit TolA_bind_tri PF16331.5 PIK62080.1 - 9.3 6.4 9.1 2.8 8.1 0.7 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation Metallophos PF00149.28 PIK62081.1 - 3.5e-07 30.9 0.2 5.4e-07 30.3 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ras PF00071.22 PIK62082.1 - 5e-42 143.3 0.1 6.3e-42 142.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK62082.1 - 4.2e-21 75.4 0.0 7.4e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK62082.1 - 7.2e-09 35.3 0.1 8.9e-09 35.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK62082.1 - 0.00023 20.7 0.0 0.00029 20.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 PIK62082.1 - 0.016 15.1 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase DUF1043 PF06295.12 PIK62082.1 - 0.045 13.8 0.0 0.064 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Secretin_N PF03958.17 PIK62082.1 - 0.088 13.2 0.4 0.32 11.4 0.2 1.9 2 1 0 2 2 2 0 Bacterial type II/III secretion system short domain RabGAP-TBC PF00566.18 PIK62084.1 - 1e-48 165.9 8.0 1.5e-48 165.3 8.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Epimerase PF01370.21 PIK62085.1 - 2.9e-53 180.8 0.0 3.8e-53 180.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 PIK62085.1 - 3.2e-10 39.9 0.0 4.5e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 PIK62085.1 - 1.3e-06 27.8 0.0 1.2e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 PIK62085.1 - 7.7e-05 22.0 0.1 0.0022 17.2 0.1 2.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NICE-3 PF07406.11 PIK62085.1 - 0.083 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NICE-3 protein CLCA PF08434.11 PIK62086.1 - 1.3e-27 96.8 0.0 1.5e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal PTAC PF06130.12 PIK62086.1 - 0.2 11.8 0.0 12 6.1 0.0 2.2 2 0 0 2 2 2 0 Phosphate propanoyltransferase VWA PF00092.28 PIK62088.1 - 0.011 15.9 0.0 0.031 14.5 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain Nucleos_tra2_C PF07662.13 PIK62089.1 - 9.1e-81 270.6 1.8 9.1e-81 270.6 1.8 2.1 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Gate PF07670.14 PIK62089.1 - 1.5e-09 38.1 3.9 1.5e-09 38.1 3.9 3.3 5 0 0 5 5 5 1 Nucleoside recognition FtsL PF04999.13 PIK62089.1 - 0.12 12.4 3.8 0.38 10.8 0.3 3.0 3 0 0 3 3 3 0 Cell division protein FtsL CUB PF00431.20 PIK62090.1 - 6.1e-49 165.0 0.6 1.6e-23 83.1 0.2 2.4 2 0 0 2 2 2 2 CUB domain PADR1 PF08063.12 PIK62090.1 - 8 6.3 11.7 1 9.2 0.1 4.4 5 0 0 5 5 5 0 PADR1 (NUC008) domain 7tm_2 PF00002.24 PIK62091.1 - 2.3e-18 66.4 25.4 3e-18 66.0 25.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Mid2 PF04478.12 PIK62091.1 - 5 6.9 7.8 3.4 7.5 0.6 2.9 2 1 0 2 2 2 0 Mid2 like cell wall stress sensor Fibrinogen_C PF00147.18 PIK62092.1 - 4.5e-43 147.6 14.7 2.2e-42 145.4 14.7 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62092.1 - 2.7e-07 30.4 13.9 2.7e-07 30.4 13.9 4.7 3 1 2 5 5 5 1 TILa domain TIL PF01826.17 PIK62092.1 - 6.3e-07 29.6 15.3 6.3e-07 29.6 15.3 5.3 4 1 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK62092.1 - 0.0038 17.4 12.4 0.0038 17.4 12.4 5.0 4 1 0 4 4 4 1 EGF domain Thymidylate_kin PF02223.17 PIK62092.1 - 0.38 10.4 3.0 2.9 7.5 1.4 2.6 1 1 1 2 2 2 0 Thymidylate kinase Mating_N PF12731.7 PIK62093.1 - 0.027 14.6 0.2 0.16 12.1 0.1 2.2 2 0 0 2 2 2 0 Mating-type protein beta 1 UPF0449 PF15136.6 PIK62093.1 - 0.047 14.2 2.6 0.21 12.0 0.2 2.5 1 1 2 3 3 3 0 Uncharacterised protein family UPF0449 Prominin PF05478.11 PIK62093.1 - 0.053 11.5 0.1 0.059 11.3 0.1 1.1 1 0 0 1 1 1 0 Prominin CEP209_CC5 PF16574.5 PIK62094.1 - 6.6e-44 149.2 25.5 6.6e-44 149.2 25.5 19.7 8 5 12 22 22 22 1 Coiled-coil region of centrosome protein CE290 NPL PF17800.1 PIK62095.1 - 1.1e-14 54.9 0.3 2.6e-14 53.6 0.3 1.6 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-H2C2_2 PF13465.6 PIK62095.1 - 9.2e-12 44.8 21.8 9.3e-06 25.9 1.1 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 PIK62095.1 - 6.6e-06 26.3 19.9 0.014 15.8 1.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK62095.1 - 6.6e-05 23.4 20.1 0.23 12.4 1.5 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK62095.1 - 0.0037 17.5 20.3 0.077 13.3 2.5 4.1 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 PIK62095.1 - 0.15 11.9 5.7 9.6 6.2 0.2 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 PIK62095.1 - 0.38 10.8 11.4 7.7 6.6 0.2 3.5 1 1 2 3 3 3 0 BED zinc finger Zf_RING PF16744.5 PIK62095.1 - 0.97 9.6 6.2 0.41 10.8 0.4 3.1 2 1 2 4 4 4 0 KIAA1045 RING finger zf-AN1 PF01428.16 PIK62095.1 - 3.2 8.0 14.2 11 6.2 0.1 3.4 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 PIK62095.1 - 8 7.2 11.0 2 9.1 0.8 3.6 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats TRH PF05438.12 PIK62096.1 - 0.027 14.2 0.2 0.027 14.2 0.2 1.9 2 0 0 2 2 2 0 Thyrotropin-releasing hormone (TRH) BID PF06393.11 PIK62096.1 - 0.14 11.7 2.9 0.082 12.4 0.3 1.9 1 1 0 1 1 1 0 BH3 interacting domain (BID) TLP-20 PF06088.11 PIK62096.1 - 7 6.5 10.7 27 4.6 10.6 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) SBP_bac_3 PF00497.20 PIK62097.1 - 1.6e-07 31.0 0.0 0.0092 15.4 0.0 2.6 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_3 PF00497.20 PIK62098.1 - 1.1e-18 67.6 0.0 1.9e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SCAN PF02023.17 PIK62099.1 - 1.3e-14 53.8 0.6 3.3e-14 52.5 0.6 1.8 1 0 0 1 1 1 1 SCAN domain RVP PF00077.20 PIK62099.1 - 0.00047 20.4 0.0 0.0014 18.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease SBP_bac_3 PF00497.20 PIK62100.1 - 1.3e-06 28.0 0.0 3.6e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Receptor_2B4 PF11465.8 PIK62100.1 - 0.11 12.7 0.1 0.78 10.0 0.1 2.2 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 FliH PF02108.16 PIK62101.1 - 0.091 12.8 0.0 0.34 11.0 0.0 1.7 1 1 1 2 2 2 0 Flagellar assembly protein FliH Collagen PF01391.18 PIK62102.1 - 0.0014 18.4 1.8 0.0024 17.6 1.8 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RVT_1 PF00078.27 PIK62102.1 - 0.031 13.8 0.0 0.059 12.9 0.0 1.5 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pyr_redox_2 PF07992.14 PIK62103.1 - 1.1e-13 51.1 0.0 2.1e-07 30.5 0.0 1.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 PIK62103.1 - 8.6e-08 31.8 0.1 1.9e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 PIK62103.1 - 2.2e-06 27.0 0.1 4e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 PIK62103.1 - 4.8e-06 26.1 0.1 1.1e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 PIK62103.1 - 0.0001 21.2 0.1 0.00022 20.1 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 PIK62103.1 - 0.00014 21.2 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 PIK62103.1 - 0.00041 20.9 0.1 0.0013 19.3 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 PIK62103.1 - 0.00057 20.1 0.0 0.0015 18.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 PIK62103.1 - 0.00099 19.5 0.2 0.0058 17.1 0.1 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 PIK62103.1 - 0.0027 17.1 0.0 0.0064 15.9 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 PIK62103.1 - 0.0029 17.2 0.1 0.0053 16.4 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 PIK62103.1 - 0.0032 16.6 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 PIK62103.1 - 0.0041 16.5 0.1 0.0069 15.8 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 PIK62103.1 - 0.0061 15.7 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A ThiF PF00899.21 PIK62103.1 - 0.013 14.9 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.20 PIK62103.1 - 0.032 14.3 0.1 0.075 13.1 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase XdhC_C PF13478.6 PIK62103.1 - 0.043 14.3 0.1 0.41 11.2 0.0 2.4 2 1 0 2 2 2 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 PIK62103.1 - 0.053 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 PIK62103.1 - 2.7 7.8 5.3 1.5 8.6 0.0 3.1 4 0 0 4 4 4 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 PIK62104.1 - 1.2e-25 90.4 0.0 2.1e-22 79.7 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62104.1 - 1.9e-13 50.3 0.0 3.5e-09 36.3 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.22 PIK62104.1 - 0.007 16.0 0.4 0.02 14.5 0.1 1.9 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 PIK62104.1 - 0.012 15.0 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 PIK62104.1 - 0.026 13.5 0.0 0.042 12.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 PIK62104.1 - 0.055 13.4 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cyclin_N PF00134.23 PIK62105.1 - 5e-32 110.3 0.9 6.3e-32 110.0 0.9 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ion_trans PF00520.31 PIK62106.1 - 0.0053 16.0 7.0 0.0064 15.7 7.0 1.0 1 0 0 1 1 1 1 Ion transport protein ESSS PF10183.9 PIK62106.1 - 0.0072 16.5 0.8 0.0084 16.3 0.8 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ThiS-like PF14453.6 PIK62106.1 - 0.16 12.1 0.1 0.41 10.7 0.0 1.7 2 0 0 2 2 2 0 ThiS-like ubiquitin Ion_trans PF00520.31 PIK62107.1 - 6.2e-12 45.3 19.7 1.6e-10 40.6 8.4 2.1 2 0 0 2 2 2 2 Ion transport protein Ion_trans PF00520.31 PIK62108.1 - 8e-13 48.2 8.1 1.1e-12 47.8 8.1 1.1 1 0 0 1 1 1 1 Ion transport protein Lectin_C PF00059.21 PIK62109.1 - 6.6e-18 65.4 1.0 1e-17 64.8 1.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK62109.1 - 0.00032 20.4 0.3 0.00053 19.7 0.1 1.4 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like RVT_1 PF00078.27 PIK62110.1 - 4.2e-18 65.7 0.0 4.7e-17 62.2 0.0 2.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK62110.1 - 1.1e-09 38.1 0.0 2.3e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62110.1 - 1.3e-09 38.0 0.0 2.5e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NACHT PF05729.12 PIK62111.1 - 2.3e-22 79.7 0.0 9.6e-22 77.7 0.0 2.2 1 0 0 1 1 1 1 NACHT domain Death PF00531.22 PIK62111.1 - 8.1e-12 45.2 2.0 1.1e-11 44.7 0.1 2.2 2 0 0 2 2 2 1 Death domain NLRC4_HD PF17889.1 PIK62111.1 - 0.45 10.9 3.8 0.83 10.0 0.1 3.1 2 0 0 2 2 2 0 NLRC4 helical domain PDZ PF00595.24 PIK62112.1 - 1.1e-41 141.1 3.4 1.5e-11 44.5 0.6 4.8 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 PIK62112.1 - 5.5e-28 96.6 0.1 1.2e-06 28.3 0.0 4.8 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 PIK62112.1 - 3e-13 49.9 0.6 0.016 15.6 0.0 4.6 3 1 0 4 4 4 4 PDZ domain Guanylate_kin PF00625.21 PIK62112.1 - 4.5e-11 42.8 0.4 7.3e-10 38.8 0.0 3.2 2 1 0 2 2 2 1 Guanylate kinase SH3_2 PF07653.17 PIK62112.1 - 0.0034 17.0 0.0 0.0073 16.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 PIK62112.1 - 0.021 14.4 0.0 0.055 13.1 0.0 1.8 1 0 0 1 1 1 0 SH3 domain SH3_9 PF14604.6 PIK62112.1 - 0.19 11.6 0.0 0.59 10.0 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain SH3_13 PF18335.1 PIK62112.1 - 0.49 10.3 2.6 0.53 10.2 0.3 2.4 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain PRAS PF15798.5 PIK62113.1 - 0.11 13.0 0.6 0.15 12.6 0.6 1.3 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 zf-MIZ PF02891.20 PIK62114.1 - 3.7e-22 77.8 4.9 3.7e-22 77.8 4.9 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 PIK62114.1 - 1.1e-05 25.1 1.4 1.1e-05 25.1 1.4 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit RskA PF10099.9 PIK62114.1 - 0.0063 16.8 7.1 0.011 16.1 7.1 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DEC-1_N PF04625.13 PIK62115.1 - 0.37 9.7 6.1 0.36 9.8 6.1 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region CD24 PF14984.6 PIK62115.1 - 0.68 10.2 7.2 2.7 8.3 4.4 2.3 1 1 1 2 2 2 0 CD24 protein CAP_N PF01213.19 PIK62115.1 - 6.3 6.2 9.2 7.3 6.0 9.2 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ELFV_dehydrog_N PF02812.18 PIK62116.1 - 2.5e-35 121.2 0.0 3.3e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain PCI PF01399.27 PIK62117.1 - 1.7e-19 70.2 1.3 4.4e-19 68.9 0.0 2.2 2 1 0 2 2 2 1 PCI domain CSN4_RPN5_eIF3a PF18420.1 PIK62117.1 - 3.9e-18 65.3 2.4 1e-17 63.9 2.4 1.8 1 0 0 1 1 1 1 CSN4/RPN5/eIF3a helix turn helix domain TPR_12 PF13424.6 PIK62117.1 - 0.1 12.9 3.3 1.4 9.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK62117.1 - 0.12 12.5 0.5 1.9 8.7 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 PIK62117.1 - 0.25 12.3 2.2 1.4 10.0 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF2057 PF09829.9 PIK62118.1 - 0.96 9.6 10.9 0.37 10.9 0.2 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2057) TCR PF03638.15 PIK62119.1 - 2.6e-12 46.8 42.9 3.6e-10 40.0 28.1 3.0 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain DUF2369 PF10179.9 PIK62120.1 - 2.7e-17 62.9 0.0 6.7e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 PIK62120.1 - 0.0052 17.1 3.1 0.11 12.8 0.0 3.2 3 0 0 3 3 3 1 Fibronectin type III domain fn3_4 PF16794.5 PIK62120.1 - 0.052 13.5 0.1 0.43 10.5 0.1 2.3 2 0 0 2 2 2 0 Fibronectin-III type domain 7tm_1 PF00001.21 PIK62121.1 - 1.3e-10 41.1 7.1 2e-10 40.4 7.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Plexin_cytopl PF08337.12 PIK62122.1 - 0.19 10.4 4.5 0.3 9.7 4.5 1.3 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain Peptidase_M10 PF00413.24 PIK62123.1 - 1.7e-47 161.2 0.1 5.4e-47 159.6 0.1 1.8 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.19 PIK62123.1 - 3.9e-09 36.3 8.1 7.9e-06 25.7 0.5 5.1 5 0 0 5 5 5 1 Hemopexin PG_binding_1 PF01471.18 PIK62123.1 - 3.8e-08 33.4 0.1 8.4e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Metallopep PF12044.8 PIK62123.1 - 0.066 11.8 0.1 0.1 11.2 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 PIK62123.1 - 0.089 13.3 0.1 0.19 12.2 0.1 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK62123.1 - 0.2 10.9 0.4 0.38 9.9 0.4 1.4 1 0 0 1 1 1 0 Met-zincin Astacin PF01400.24 PIK62123.1 - 0.2 11.2 0.7 4.2 7.0 0.2 2.4 1 1 1 2 2 2 0 Astacin (Peptidase family M12A) Hemopexin PF00045.19 PIK62124.1 - 1.9e-44 149.3 12.6 7.3e-16 57.9 0.3 4.1 4 0 0 4 4 4 4 Hemopexin DUF5074 PF16819.5 PIK62124.1 - 0.02 15.0 1.0 2.8 8.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) TPR_1 PF00515.28 PIK62124.1 - 0.33 10.8 1.5 0.56 10.1 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Glycoprotein_B PF00606.18 PIK62124.1 - 2.5 7.5 4.4 13 5.1 0.0 2.5 3 0 0 3 3 3 0 Herpesvirus Glycoprotein B ectodomain Peptidase_M10 PF00413.24 PIK62125.1 - 3.4e-20 72.5 0.0 4.4e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK62126.1 - 7.1e-47 157.1 13.1 1.8e-15 56.6 0.3 4.4 4 0 0 4 4 4 4 Hemopexin Peptidase_M10 PF00413.24 PIK62126.1 - 2.3e-16 60.0 0.1 3.9e-16 59.3 0.1 1.3 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 PIK62126.1 - 0.0095 14.9 1.7 0.015 14.3 1.7 1.2 1 0 0 1 1 1 1 Peptidase M66 Metallopep PF12044.8 PIK62126.1 - 0.041 12.5 0.1 0.06 11.9 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 PIK62126.1 - 0.069 13.7 1.0 0.15 12.6 1.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 PIK62126.1 - 0.15 12.2 0.3 0.28 11.3 0.3 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 PIK62126.1 - 0.18 11.4 0.3 0.31 10.6 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 PIK62127.1 - 3e-27 95.4 0.0 4e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 PIK62127.1 - 3.2e-05 24.0 0.0 5.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Hemopexin PF00045.19 PIK62128.1 - 2.5e-35 120.1 7.5 1.6e-12 47.2 0.2 4.1 4 0 0 4 4 4 4 Hemopexin Exo_endo_phos PF03372.23 PIK62129.1 - 1.4e-18 67.2 0.0 3.4e-17 62.7 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 PIK62129.1 - 4.5e-12 45.5 14.1 1.7e-11 43.7 6.6 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 PIK62129.1 - 3.3e-08 33.7 16.3 3.1e-06 27.4 4.8 3.0 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK62129.1 - 0.011 15.3 1.4 0.036 13.6 1.4 1.8 1 1 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 PIK62129.1 - 2.5 8.4 12.4 4.1 7.7 1.3 4.3 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 PIK62129.1 - 3.4 8.6 18.7 16 6.5 0.2 5.5 5 1 0 5 5 5 0 Leucine Rich Repeat HlyIII PF03006.20 PIK62130.1 - 5.7e-37 127.6 14.5 6.5e-37 127.4 14.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3981 PF13139.6 PIK62130.1 - 0.87 10.0 4.0 0.74 10.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3981) KCT2 PF17818.1 PIK62131.1 - 3.2e-09 37.2 2.0 3.2e-09 37.2 2.0 1.9 1 1 1 2 2 2 1 Keratinocyte-associated gene product LRR_8 PF13855.6 PIK62132.1 - 1.4e-54 181.7 48.2 1.1e-14 53.9 6.9 7.3 5 2 2 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 PIK62132.1 - 1.1e-31 108.4 50.0 2.5e-06 27.7 1.2 8.3 6 2 1 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK62132.1 - 2.5e-28 98.6 6.9 3.1e-13 49.8 1.2 3.2 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 PIK62132.1 - 5.7e-14 50.5 44.7 0.39 11.5 0.4 12.1 12 1 0 12 12 12 7 Leucine Rich Repeat LRR_9 PF14580.6 PIK62132.1 - 8.6e-12 44.9 6.2 0.0058 16.1 0.1 4.1 2 2 0 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 PIK62132.1 - 0.00012 21.8 58.5 0.064 13.3 0.6 11.2 12 0 0 12 12 12 4 Leucine Rich repeat Pkinase PF00069.25 PIK62134.1 - 3e-69 233.3 0.0 3.9e-69 233.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62134.1 - 5.1e-34 117.7 0.0 8.6e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 PIK62134.1 - 1.4e-08 34.7 0.0 3.6e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Kinase-like PF14531.6 PIK62134.1 - 1.9e-05 24.2 0.0 3.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 PIK62134.1 - 0.0062 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 PIK62134.1 - 0.022 14.4 0.1 6.4 6.3 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 PIK62134.1 - 0.031 13.1 0.0 0.062 12.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 PIK62134.1 - 0.088 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 cNMP_binding PF00027.29 PIK62135.1 - 5.4e-19 68.1 0.1 2.8e-12 46.5 0.0 2.1 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain AIG1 PF04548.16 PIK62136.1 - 2.9e-25 88.8 2.1 2.3e-16 59.8 0.1 2.1 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.23 PIK62136.1 - 1.3e-05 25.2 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 PIK62136.1 - 0.046 13.8 0.2 7.1 6.7 0.0 3.0 2 2 1 3 3 3 0 Dynamin family AIG1 PF04548.16 PIK62137.1 - 1.8e-38 132.0 1.2 3.2e-38 131.2 1.2 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 PIK62137.1 - 2.6e-08 33.9 0.4 2.3e-07 30.9 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK62137.1 - 0.0015 18.1 0.2 0.0066 16.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 PIK62137.1 - 0.0022 18.1 3.8 0.79 9.8 0.4 2.9 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 PIK62137.1 - 0.036 14.0 0.9 0.37 10.7 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase Nmad4 PF18756.1 PIK62137.1 - 0.058 13.7 0.5 12 6.3 0.0 3.0 3 1 0 3 3 3 0 Nucleotide modification associated domain 4 ABC_tran PF00005.27 PIK62137.1 - 0.53 10.8 2.1 0.93 10.0 1.8 2.0 1 1 0 1 1 1 0 ABC transporter AIG1 PF04548.16 PIK62138.1 - 0.025 13.9 0.2 0.052 12.9 0.1 1.6 2 0 0 2 2 2 0 AIG1 family AbiGi PF10899.8 PIK62138.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Hormone_recep PF00104.30 PIK62139.1 - 4.5e-05 23.1 0.1 6.1e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Cornifin PF02389.15 PIK62140.1 - 6.6e-07 29.6 5.3 3.8e-06 27.1 5.3 2.4 1 0 0 1 1 1 1 Cornifin (SPRR) family Chromo_shadow PF01393.19 PIK62142.1 - 1.2e-28 98.9 0.6 5.9e-25 87.1 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 PIK62142.1 - 2.4e-20 72.2 0.8 6.1e-17 61.3 1.0 2.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.32 PIK62143.1 - 4.4e-07 30.5 16.5 0.0051 17.6 1.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK62143.1 - 4.8e-05 23.6 0.0 0.0055 17.0 0.0 3.7 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 PIK62143.1 - 0.083 12.6 0.1 7.2 6.3 0.1 3.3 4 0 0 4 4 4 0 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 PIK62145.1 - 0.00031 21.0 0.0 0.032 14.5 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 PIK62145.1 - 0.0017 19.2 0.8 0.033 15.1 0.0 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat VID27 PF08553.10 PIK62145.1 - 0.0072 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain HPS3_N PF14761.6 PIK62145.1 - 0.12 11.9 0.3 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 SCAN PF02023.17 PIK62146.1 - 9.8e-14 50.9 0.0 2e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-CCHC PF00098.23 PIK62146.1 - 7.1e-07 29.0 2.0 1.7e-06 27.8 2.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 PIK62146.1 - 0.0016 18.2 1.4 0.0033 17.2 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle CitX PF03802.14 PIK62146.1 - 0.036 13.8 0.8 0.083 12.6 0.4 1.8 1 1 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase zf-CCHC_5 PF14787.6 PIK62146.1 - 0.24 11.2 2.0 0.44 10.3 2.0 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Retrotrans_gag PF03732.17 PIK62146.1 - 0.46 10.8 7.4 2.3 8.5 0.2 3.2 2 1 0 3 3 3 0 Retrotransposon gag protein rve PF00665.26 PIK62147.1 - 3.5e-17 62.7 0.0 6.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62147.1 - 0.0013 18.8 1.7 0.0033 17.5 1.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK62147.1 - 0.0019 17.9 0.1 0.017 14.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.9 PIK62147.1 - 0.058 13.5 0.2 0.1 12.7 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 RT_RNaseH_2 PF17919.1 PIK62148.1 - 1.7e-37 127.4 0.0 3.5e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62148.1 - 1.3e-35 121.8 0.0 3e-35 120.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62148.1 - 2.6e-26 92.5 0.0 4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 PIK62149.1 - 0.00022 20.8 0.0 0.00042 19.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_transf_10 PF00852.19 PIK62150.1 - 1.3e-51 174.9 0.8 2.1e-51 174.1 0.8 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 PIK62150.1 - 3e-06 27.6 0.2 5.6e-06 26.8 0.2 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Branch PF02485.21 PIK62151.1 - 1.7e-43 148.9 0.0 2e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Sin3a_C PF16879.5 PIK62152.1 - 2.6e-80 270.2 9.7 1.1e-77 261.5 9.7 3.3 1 1 0 1 1 1 1 C-terminal domain of Sin3a protein PAH PF02671.21 PIK62152.1 - 3.3e-46 155.2 7.6 4.6e-18 65.1 2.2 3.9 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 PIK62152.1 - 3.7e-42 142.4 0.5 1.7e-41 140.2 0.5 2.2 1 0 0 1 1 1 1 Sin3 family co-repressor IR1-M PF12185.8 PIK62152.1 - 0.11 12.5 2.3 0.34 10.9 2.3 1.8 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain TIR_2 PF13676.6 PIK62153.1 - 1.2e-20 74.3 0.0 2.9e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 TIR domain Arm PF00514.23 PIK62153.1 - 3.2e-05 23.8 0.0 0.00037 20.4 0.0 2.7 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat SAM_1 PF00536.30 PIK62153.1 - 3.8e-05 24.1 0.3 0.00012 22.4 0.3 2.0 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 PIK62153.1 - 8.8e-05 22.5 0.4 0.00059 19.9 0.4 2.4 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) WAPL PF07814.13 PIK62153.1 - 0.002 17.0 0.9 0.002 17.0 0.9 1.6 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin SAM_3 PF18016.1 PIK62153.1 - 0.0035 17.1 0.1 0.01 15.6 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) V-ATPase_H_N PF03224.14 PIK62153.1 - 0.0084 15.4 0.8 0.018 14.3 0.8 1.5 1 0 0 1 1 1 1 V-ATPase subunit H HEAT_EZ PF13513.6 PIK62153.1 - 0.027 15.0 0.1 0.16 12.5 0.0 2.4 2 0 0 2 2 2 0 HEAT-like repeat SIL1 PF16782.5 PIK62153.1 - 0.037 13.2 0.4 0.1 11.8 0.4 1.7 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 DUF4542 PF15075.6 PIK62154.1 - 8.4e-50 168.7 0.1 1.2e-49 168.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4542) NAD_binding_2 PF03446.15 PIK62155.1 - 1.8e-47 161.4 0.5 2.6e-47 160.9 0.5 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 PIK62155.1 - 1.4e-34 118.9 0.0 2.7e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 PIK62155.1 - 4.5e-07 29.4 0.0 8e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 PIK62155.1 - 9.7e-07 29.3 0.0 4.1e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 PIK62155.1 - 0.0018 18.2 0.1 0.0049 16.8 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 PIK62155.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 PIK62155.1 - 0.032 14.5 0.1 0.057 13.7 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 PIK62155.1 - 0.052 13.8 0.0 1 9.6 0.0 2.2 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 PIK62155.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 PIK62155.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Rtt106_N PF18215.1 PIK62155.1 - 0.13 12.0 0.4 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Histone chaperone Rtt106 N-terminal domain HisKA_7TM PF16927.5 PIK62156.1 - 0.0018 18.4 0.3 0.0034 17.4 0.3 1.4 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase Big_2 PF02368.18 PIK62157.1 - 4.8e-20 71.2 13.4 1e-06 28.5 0.0 8.3 9 0 0 9 9 9 4 Bacterial Ig-like domain (group 2) CBM-like PF14683.6 PIK62157.1 - 0.11 12.4 0.2 0.49 10.2 0.0 2.2 3 0 0 3 3 3 0 Polysaccharide lyase family 4, domain III DUF1554 PF07588.11 PIK62157.1 - 0.17 11.7 0.0 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1554) Dynactin_p62 PF05502.13 PIK62158.1 - 4.5e-25 88.4 6.9 4.2e-15 55.5 0.6 2.0 2 0 0 2 2 2 2 Dynactin p62 family zf-3CxxC PF13695.6 PIK62158.1 - 0.017 15.6 6.7 1.4 9.4 2.0 2.7 1 1 2 3 3 3 0 Zinc-binding domain Cobalamin_bind PF01122.19 PIK62159.1 - 4.6e-20 71.8 0.0 6.2e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein TED_complement PF07678.14 PIK62159.1 - 0.065 12.3 0.5 0.64 9.0 0.2 2.1 2 0 0 2 2 2 0 A-macroglobulin TED domain SQHop_cyclase_C PF13243.6 PIK62159.1 - 0.12 11.5 0.3 2.2 7.3 0.1 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain Mesd PF10185.9 PIK62160.1 - 2.4e-60 203.0 9.0 3.4e-60 202.5 9.0 1.2 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor LSM PF01423.22 PIK62161.1 - 4.3e-20 71.2 0.0 1.1e-12 47.4 0.0 2.1 1 1 1 2 2 2 2 LSM domain Sox_N PF12444.8 PIK62161.1 - 0.066 14.3 0.3 21 6.3 0.1 2.2 2 0 0 2 2 2 0 Sox developmental protein N terminal Peptidase_A22B PF04258.13 PIK62162.1 - 1.4e-70 238.1 20.6 1.8e-70 237.7 20.6 1.0 1 0 0 1 1 1 1 Signal peptide peptidase Presenilin PF01080.17 PIK62162.1 - 3.4 6.3 28.0 0.16 10.7 15.3 2.1 2 0 0 2 2 2 0 Presenilin KH_1 PF00013.29 PIK62163.1 - 6.5e-09 35.5 0.1 1e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 PIK62163.1 - 0.00072 19.3 0.2 0.0012 18.6 0.2 1.3 1 0 0 1 1 1 1 KH domain Androgen_recep PF02166.16 PIK62163.1 - 0.031 13.1 7.2 0.038 12.8 7.2 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 PIK62163.1 - 0.035 13.7 6.7 0.045 13.4 6.7 1.2 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 PIK62163.1 - 0.038 12.9 4.3 0.041 12.8 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AviRa PF11599.8 PIK62163.1 - 0.97 8.8 5.6 2.6 7.5 0.0 2.5 1 1 0 2 2 2 0 RRNA methyltransferase AviRa KH_1 PF00013.29 PIK62164.1 - 2.3e-18 65.8 0.6 2.3e-18 65.8 0.6 1.5 2 0 0 2 2 2 1 KH domain KH_2 PF07650.17 PIK62164.1 - 0.027 14.3 0.3 0.027 14.3 0.3 1.6 2 0 0 2 2 2 0 KH domain KH_5 PF13184.6 PIK62164.1 - 0.028 14.5 0.2 0.028 14.5 0.2 1.7 2 0 0 2 2 2 0 NusA-like KH domain KH_4 PF13083.6 PIK62164.1 - 1.7 8.6 4.9 4.7 7.2 0.1 2.6 3 0 0 3 3 3 0 KH domain CoA_transf_3 PF02515.17 PIK62165.1 - 9.6e-11 41.4 0.1 1.2e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 CoA-transferase family III CoA_transf_3 PF02515.17 PIK62166.1 - 2.9e-63 214.2 0.3 7.1e-63 212.9 0.3 1.5 1 1 0 1 1 1 1 CoA-transferase family III SdiA-regulated PF06977.11 PIK62166.1 - 0.053 12.7 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 SdiA-regulated MRG PF05712.13 PIK62167.1 - 3.4e-54 183.2 3.3 7e-54 182.2 3.3 1.5 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 PIK62167.1 - 4.1e-13 49.0 0.1 4.1e-13 49.0 0.1 2.5 3 0 0 3 3 3 1 RNA binding activity-knot of a chromodomain Presenilin PF01080.17 PIK62167.1 - 0.071 11.9 2.9 0.088 11.6 2.9 1.1 1 0 0 1 1 1 0 Presenilin DUF3408 PF11888.8 PIK62167.1 - 0.18 11.9 5.4 0.31 11.2 5.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) FAM76 PF16046.5 PIK62167.1 - 0.67 9.2 15.9 0.12 11.7 11.7 1.7 2 0 0 2 2 2 0 FAM76 protein zf-SNAP50_C PF12251.8 PIK62168.1 - 2.4e-62 210.2 4.3 4e-62 209.5 4.3 1.3 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal tRNA-synt_2b PF00587.25 PIK62169.1 - 1.2e-28 100.3 0.0 2.3e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 PIK62169.1 - 1e-20 73.7 0.1 1.8e-20 72.9 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 PIK62169.1 - 4.9e-13 49.0 0.0 1.1e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 PIK62169.1 - 4.5e-07 29.8 0.0 2.7e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 TGS domain DDE_Tnp_ISAZ013 PF07592.11 PIK62169.1 - 0.068 12.1 0.7 9.3 5.1 0.1 2.3 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain Ints3 PF10189.9 PIK62170.1 - 8.7e-71 237.8 0.6 5.2e-68 228.7 0.2 2.7 1 1 1 2 2 2 2 Integrator complex subunit 3 Phage_Mu_Gam PF07352.12 PIK62170.1 - 0.069 13.1 0.1 0.21 11.5 0.1 1.8 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Ribosomal_S16 PF00886.19 PIK62171.1 - 3.8e-24 84.5 0.0 6.7e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S16 Pkinase_Tyr PF07714.17 PIK62173.1 - 1.3e-56 191.8 0.4 1.2e-42 146.0 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 PIK62173.1 - 7.3e-22 78.0 0.1 1.6e-13 50.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain SH2 PF00017.24 PIK62173.1 - 0.0035 17.4 0.0 0.0077 16.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain DUF3182 PF11379.8 PIK62173.1 - 0.14 11.1 0.0 0.68 8.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3182) Pkinase_Tyr PF07714.17 PIK62174.1 - 7.3e-89 297.5 0.0 9.5e-89 297.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62174.1 - 1.2e-44 152.6 0.0 1.7e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 PIK62174.1 - 3.4e-05 24.3 0.2 0.00042 20.9 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK62174.1 - 9e-05 22.5 0.0 0.04 14.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 PIK62174.1 - 0.00023 21.3 0.2 0.0038 17.4 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Haspin_kinase PF12330.8 PIK62174.1 - 0.18 10.7 0.0 0.3 10.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Insulin_TMD PF17870.1 PIK62174.1 - 0.23 11.6 2.7 0.27 11.3 1.1 1.9 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment GST_C_6 PF17171.4 PIK62175.1 - 9.6e-23 79.8 0.1 1.9e-22 78.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 PIK62175.1 - 3.6e-22 79.0 0.0 6.1e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 PIK62175.1 - 1.3e-11 45.1 0.0 2.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 PIK62175.1 - 9.6e-05 22.3 0.0 0.00021 21.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 PIK62175.1 - 0.061 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 PIK62175.1 - 0.096 12.9 0.2 0.55 10.5 0.0 2.2 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain RWD PF05773.22 PIK62176.1 - 0.12 12.7 0.1 1.3 9.3 0.0 2.6 2 0 0 2 2 2 0 RWD domain S-antigen PF05756.11 PIK62176.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.7 1 0 0 1 1 1 0 S-antigen protein SbcD_C PF12320.8 PIK62176.1 - 2.5 8.4 4.8 0.61 10.4 0.7 2.1 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Glyco_hydro_3 PF00933.21 PIK62177.1 - 1.4e-47 162.6 0.0 5.1e-47 160.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 PIK62177.1 - 9e-43 146.6 0.0 1.3e-42 146.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 PIK62177.1 - 1.8e-14 53.6 0.2 4.4e-14 52.4 0.1 1.7 2 0 0 2 2 2 1 Fibronectin type III-like domain ADH_N PF08240.12 PIK62178.1 - 2e-30 104.9 0.7 3.5e-30 104.1 0.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK62178.1 - 8.4e-16 58.1 0.0 1.3e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK62178.1 - 3.2e-09 36.6 0.0 2.7e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK62178.1 - 0.0011 18.3 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 PIK62179.1 - 9.6e-31 105.9 1.7 1.8e-30 105.0 1.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 PIK62179.1 - 1.7e-18 66.9 0.0 2.4e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 PIK62179.1 - 8.3e-09 35.2 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 PIK62179.1 - 0.00016 21.1 0.0 0.00026 20.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 PIK62179.1 - 0.05 13.2 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_16 PF10294.9 PIK62179.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase 2-Hacid_dh_C PF02826.19 PIK62179.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-synt_ab PF00006.25 PIK62180.1 - 2e-69 233.5 0.0 3e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 PIK62180.1 - 2.5e-47 160.3 1.3 3.7e-47 159.8 1.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain DUF4142 PF13628.6 PIK62180.1 - 3.2e-05 24.2 0.8 5.8e-05 23.3 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) ATPase PF06745.13 PIK62180.1 - 0.045 13.1 0.1 0.093 12.1 0.1 1.6 1 0 0 1 1 1 0 KaiC ATP-synt_ab_N PF02874.23 PIK62181.1 - 4.5e-19 68.7 1.8 4.5e-19 68.7 1.8 1.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 PIK62181.1 - 0.013 15.7 1.1 0.086 13.0 1.2 2.2 1 1 1 2 2 2 0 HAS barrel domain ARF7EP_C PF14949.6 PIK62182.1 - 1.6e-27 96.2 8.3 1.6e-27 96.2 8.3 2.9 1 1 2 3 3 3 1 ARF7 effector protein C-terminus THAP PF05485.12 PIK62182.1 - 3.5e-09 37.5 1.1 1.7e-08 35.3 1.1 2.3 1 0 0 1 1 1 1 THAP domain zf-CCCH PF00642.24 PIK62183.1 - 3.8e-13 49.0 30.8 2.3e-05 24.1 2.1 4.2 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CHY PF05495.12 PIK62183.1 - 1.6e-12 47.7 10.1 1.6e-12 47.7 10.1 4.6 5 0 0 5 5 5 1 CHY zinc finger zf_CCCH_4 PF18345.1 PIK62183.1 - 1.4e-11 44.0 45.5 8.6e-06 25.6 7.1 5.1 5 0 0 5 5 5 3 Zinc finger domain zf-CCCH_4 PF18044.1 PIK62183.1 - 4.5e-10 39.1 33.9 0.00061 19.5 2.1 4.8 5 0 0 5 5 5 3 CCCH-type zinc finger Torus PF16131.5 PIK62183.1 - 6.2e-10 39.8 15.4 0.0037 17.9 0.1 4.2 3 1 1 4 4 4 3 Torus domain zf-CCCH_2 PF14608.6 PIK62183.1 - 0.0015 18.9 3.2 0.0015 18.9 3.2 4.3 4 0 0 4 4 4 2 RNA-binding, Nab2-type zinc finger RWD PF05773.22 PIK62183.1 - 0.0073 16.6 0.1 0.021 15.1 0.1 1.8 1 0 0 1 1 1 1 RWD domain zf-CCCH_3 PF15663.5 PIK62183.1 - 0.066 13.4 0.5 0.066 13.4 0.5 3.9 3 1 1 4 4 4 0 Zinc-finger containing family MCR PF18509.1 PIK62183.1 - 2.5 7.7 6.4 5.7 6.6 1.8 2.8 2 0 0 2 2 2 0 Magnetochrome domain HypA PF01155.19 PIK62183.1 - 4.2 7.4 17.9 0.19 11.8 0.2 3.9 3 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Adaptin_binding PF10199.9 PIK62184.1 - 7.8e-07 29.7 2.6 7.8e-07 29.7 2.6 1.7 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 DUF2334 PF10096.9 PIK62184.1 - 0.027 14.1 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) P-mevalo_kinase PF04275.14 PIK62185.1 - 5.5e-47 158.4 1.6 7.4e-47 158.0 1.6 1.2 1 0 0 1 1 1 1 Phosphomevalonate kinase AAA_18 PF13238.6 PIK62185.1 - 0.00049 20.6 0.1 0.00072 20.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain LRR_4 PF12799.7 PIK62186.1 - 2e-12 47.1 13.1 4.6e-07 30.0 0.5 4.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 PIK62186.1 - 3.3e-07 30.0 0.3 4.5e-07 29.5 0.3 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 PIK62186.1 - 1.9e-06 27.6 14.4 1.6e-05 24.6 3.0 3.6 3 1 1 4 4 4 3 Leucine rich repeat DeoRC PF00455.22 PIK62186.1 - 0.078 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 DeoR C terminal sensor domain LRR_1 PF00560.33 PIK62186.1 - 1.4 9.7 7.2 8.2 7.4 0.3 4.5 4 2 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 PIK62186.1 - 3 8.1 9.9 3.9 7.8 0.2 4.7 5 0 0 5 5 5 0 Leucine Rich repeat GCP_C_terminal PF04130.13 PIK62187.1 - 1.8e-52 178.8 9.8 3.1e-52 178.0 9.8 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 PIK62187.1 - 1.4e-50 172.7 0.3 2.7e-50 171.8 0.0 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal SCAN PF02023.17 PIK62188.1 - 3.3e-15 55.7 0.4 6.3e-15 54.8 0.4 1.5 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK62188.1 - 0.0012 19.1 2.9 0.0079 16.4 0.2 3.1 3 1 0 3 3 3 1 Retrotransposon gag protein APP_E2 PF12925.7 PIK62188.1 - 0.091 12.5 2.1 1.5 8.5 0.1 2.2 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Integrase_H2C2 PF17921.1 PIK62189.1 - 2.6e-06 27.4 0.0 4.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 PIK62190.1 - 1.4e-19 70.4 0.0 1.8e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK62190.1 - 0.0015 18.2 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK62190.1 - 0.032 14.4 0.0 0.047 13.9 0.0 1.1 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK62191.1 - 3.6e-10 39.7 0.1 1.5e-09 37.8 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2407_C PF13373.6 PIK62192.1 - 4.2 7.6 5.8 0.84 9.8 1.6 1.9 3 0 0 3 3 3 0 DUF2407 C-terminal domain zf-CCHC PF00098.23 PIK62193.1 - 0.02 15.0 0.2 0.02 15.0 0.2 1.9 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 PIK62195.1 - 1.3e-31 108.6 0.0 3.1e-31 107.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62195.1 - 3.2e-27 94.9 0.0 8.1e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62195.1 - 5.1e-17 62.1 0.1 1.2e-16 60.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.6 PIK62195.1 - 0.0027 17.4 5.7 0.0066 16.1 5.7 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Retrotrans_gag PF03732.17 PIK62195.1 - 0.0097 16.2 1.0 0.041 14.2 0.2 2.5 2 0 0 2 2 2 1 Retrotransposon gag protein APCDDC PF14921.6 PIK62195.1 - 0.029 13.8 1.0 0.054 12.9 1.0 1.4 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 Asp_protease_2 PF13650.6 PIK62195.1 - 0.03 15.0 0.0 0.094 13.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 PIK62195.1 - 0.049 14.2 0.0 0.16 12.5 0.0 2.0 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 PIK62195.1 - 4 7.7 14.7 0.034 14.2 4.1 2.8 2 1 0 2 2 2 0 Zinc knuckle gag-asp_proteas PF13975.6 PIK62196.1 - 0.038 14.6 0.0 0.071 13.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK62196.1 - 0.093 13.4 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.6 PIK62197.1 - 0.0047 17.5 0.0 0.0083 16.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 PIK62197.1 - 0.01 16.4 0.0 0.022 15.3 0.0 1.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease rve PF00665.26 PIK62198.1 - 1.1e-22 80.4 0.0 1.6e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62198.1 - 4.2e-07 30.0 1.0 7e-07 29.3 1.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK62198.1 - 3.5e-05 23.5 0.0 7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 PIK62198.1 - 3.9e-05 23.4 0.0 6.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS240 PF13610.6 PIK62198.1 - 0.045 14.0 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.27 PIK62199.1 - 1.9e-19 70.1 0.0 3.6e-19 69.2 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 PIK62200.1 - 0.00046 20.2 15.6 0.0079 16.2 3.6 2.4 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 PIK62200.1 - 0.01 16.5 0.0 0.055 14.1 0.0 2.2 2 0 0 2 2 2 0 Aspartyl protease Retrotrans_gag PF03732.17 PIK62200.1 - 0.12 12.6 0.0 0.48 10.7 0.0 2.0 1 1 1 2 2 2 0 Retrotransposon gag protein gag-asp_proteas PF13975.6 PIK62200.1 - 0.13 12.9 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Laminin_N PF00055.17 PIK62201.1 - 2.7e-32 112.2 0.1 3.2e-32 112.0 0.1 1.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Tme5_EGF_like PF09064.10 PIK62201.1 - 0.13 12.2 3.4 0.41 10.6 3.4 1.9 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Pkinase_Tyr PF07714.17 PIK62202.1 - 3.4e-11 42.9 0.0 4.4e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62202.1 - 0.00076 18.9 0.0 0.00094 18.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Calreticulin PF00262.18 PIK62203.1 - 7.6e-15 54.6 0.0 8.4e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 Calreticulin family Calreticulin PF00262.18 PIK62204.1 - 2.8e-21 75.8 1.0 3.2e-21 75.6 1.0 1.0 1 0 0 1 1 1 1 Calreticulin family Calreticulin PF00262.18 PIK62205.1 - 1.2e-18 67.2 11.4 1.2e-18 67.2 11.4 1.9 1 1 1 2 2 1 1 Calreticulin family RNA_pol_3_Rpc31 PF11705.8 PIK62205.1 - 0.0013 19.0 23.3 0.0018 18.5 23.3 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 AP3D1 PF06375.11 PIK62205.1 - 0.0044 17.3 12.9 0.0062 16.8 12.9 1.3 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 BUD22 PF09073.10 PIK62205.1 - 0.005 16.2 17.8 0.0049 16.3 17.8 1.1 1 0 0 1 1 1 1 BUD22 PPP4R2 PF09184.11 PIK62205.1 - 0.013 15.1 20.1 0.012 15.2 20.1 1.2 1 0 0 1 1 1 0 PPP4R2 NARP1 PF12569.8 PIK62205.1 - 0.071 12.0 8.8 0.078 11.9 8.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Serinc PF03348.15 PIK62205.1 - 0.076 11.9 0.3 0.084 11.8 0.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CNDH2_C PF16858.5 PIK62205.1 - 0.16 11.8 12.7 0.2 11.5 12.7 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4820 PF16091.5 PIK62205.1 - 0.56 9.5 7.5 0.7 9.2 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Smac_DIABLO PF09057.10 PIK62205.1 - 0.77 9.1 8.1 1.1 8.6 8.1 1.1 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases NPR3 PF03666.13 PIK62205.1 - 1.7 7.4 6.2 1.8 7.3 6.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 PIK62205.1 - 3.7 6.2 6.9 4.5 5.9 6.9 1.0 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 PIK62205.1 - 4.1 7.7 16.4 6.2 7.1 16.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Astro_capsid_p PF12226.8 PIK62205.1 - 4.6 6.3 19.9 6.5 5.8 19.9 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF913 PF06025.12 PIK62205.1 - 5.8 5.8 6.2 7.4 5.4 6.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peptidase_M1_N PF17900.1 PIK62206.1 - 0.00016 21.9 0.0 0.00018 21.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Ribosomal_S21e PF01249.18 PIK62207.1 - 6.8e-37 125.4 0.1 8.3e-37 125.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e DEP PF00610.21 PIK62208.1 - 1.9e-41 140.0 4.9 5.8e-24 84.0 0.8 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 PIK62208.1 - 7.3e-13 48.1 1.8 1.5e-12 47.2 1.8 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 PIK62208.1 - 8.7e-10 38.8 1.7 1.4e-09 38.1 1.7 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK62208.1 - 3.5e-06 27.3 0.4 7.8e-06 26.1 0.4 1.6 1 0 0 1 1 1 1 PDZ domain SSXT PF05030.12 PIK62208.1 - 0.055 13.1 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 SSXT protein (N-terminal region) RT_RNaseH_2 PF17919.1 PIK62209.1 - 6.1e-28 96.8 0.0 1e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62209.1 - 2.4e-25 88.9 0.0 3.7e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62209.1 - 4.5e-12 46.0 0.1 9.2e-12 45.0 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK62210.1 - 4.3e-21 75.3 0.0 2e-19 70.0 0.0 2.1 2 0 0 2 2 2 2 Integrase core domain rve_3 PF13683.6 PIK62210.1 - 7.2e-05 22.5 0.3 0.00074 19.2 0.0 2.5 3 0 0 3 3 3 1 Integrase core domain rve PF00665.26 PIK62211.1 - 2.7e-22 79.2 0.0 6.1e-21 74.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62211.1 - 6.2e-14 51.8 2.2 1.2e-13 50.9 2.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK62211.1 - 0.00026 20.7 0.0 0.002 17.9 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK62211.1 - 0.029 14.6 0.8 0.057 13.6 0.8 1.5 1 0 0 1 1 1 0 H2C2 zinc finger p450 PF00067.22 PIK62212.1 - 2.9e-62 210.9 0.0 3.7e-62 210.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62213.1 - 1e-72 245.4 0.0 1.5e-72 244.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MNE1 PF13762.6 PIK62213.1 - 0.013 15.5 0.3 0.023 14.7 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component DUF1635 PF07795.11 PIK62213.1 - 0.077 12.9 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) RRM_1 PF00076.22 PIK62214.1 - 4.3e-16 58.5 0.0 7e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.9 PIK62214.1 - 0.12 11.2 7.4 0.12 11.2 7.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RRM_3 PF08777.11 PIK62214.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA binding motif Presenilin PF01080.17 PIK62214.1 - 5.6 5.6 5.9 6.6 5.4 5.9 1.1 1 0 0 1 1 1 0 Presenilin Asn_synthase PF00733.21 PIK62215.1 - 1.8e-84 284.5 0.7 1.2e-49 169.9 0.2 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 PIK62215.1 - 1.1e-23 83.5 0.0 1.8e-23 82.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 PIK62215.1 - 7e-18 65.1 0.0 1.5e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 PIK62215.1 - 7.1e-05 22.0 0.2 0.00017 20.8 0.1 1.6 2 0 0 2 2 2 1 NAD synthase DUF3700 PF12481.8 PIK62215.1 - 0.00027 20.5 0.1 0.00078 19.0 0.1 1.7 1 1 0 1 1 1 1 Aluminium induced protein tRNA_Me_trans PF03054.16 PIK62215.1 - 0.0067 15.3 0.0 0.0098 14.7 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 PIK62215.1 - 0.014 14.9 0.1 0.024 14.2 0.1 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 PIK62215.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NMT1_3 PF16868.5 PIK62215.1 - 0.14 11.6 0.1 0.22 10.9 0.1 1.2 1 0 0 1 1 1 0 NMT1-like family TFIIIC_delta PF12657.7 PIK62216.1 - 7.5e-19 68.4 0.5 2.2e-18 66.8 0.2 1.9 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 PIK62216.1 - 2.1e-10 40.5 7.3 2.1e-10 40.5 7.3 2.5 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex SeqA PF03925.13 PIK62216.1 - 0.14 12.1 2.8 1.9 8.5 0.3 2.3 2 0 0 2 2 2 0 SeqA protein C-terminal domain DUF4606 PF15379.6 PIK62221.1 - 0.14 12.4 1.9 9.2 6.6 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4606) zf-met PF12874.7 PIK62223.1 - 5.5e-15 55.2 13.6 6.2e-07 29.6 3.1 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK62223.1 - 7.9e-08 32.4 10.5 3.6e-05 23.9 2.2 2.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 PIK62223.1 - 7.1e-05 23.1 1.1 0.14 12.4 0.2 2.5 2 0 0 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 PIK62223.1 - 0.0033 17.7 9.7 0.06 13.7 0.3 2.6 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 PIK62223.1 - 0.013 15.1 5.5 1.2 8.8 0.3 3.1 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain CarbpepA_inh PF02977.15 PIK62223.1 - 0.022 14.5 0.8 0.22 11.4 0.1 2.6 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor Hus1 PF04005.12 PIK62223.1 - 0.071 12.2 0.2 0.13 11.4 0.2 1.3 1 0 0 1 1 1 0 Hus1-like protein zf-C2H2 PF00096.26 PIK62223.1 - 0.3 11.6 5.9 2.3 8.8 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type TBPIP PF07106.13 PIK62224.1 - 1.1e-25 89.3 0.2 1.1e-25 89.3 0.2 1.9 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 PIK62224.1 - 5.1e-17 61.7 1.4 5.1e-17 61.7 1.4 2.4 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Rx_N PF18052.1 PIK62224.1 - 0.003 17.8 0.5 0.0068 16.7 0.5 1.6 1 0 0 1 1 1 1 Rx N-terminal domain SesA PF17107.5 PIK62224.1 - 0.0054 16.9 5.4 0.0092 16.2 5.2 1.5 1 1 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases CdvA PF18822.1 PIK62224.1 - 0.026 14.3 0.3 0.026 14.3 0.3 2.9 1 1 2 3 3 3 0 CdvA-like coiled-coil domain Hid1 PF12722.7 PIK62224.1 - 0.034 12.3 2.8 0.037 12.2 2.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PilJ PF13675.6 PIK62224.1 - 0.041 13.9 0.6 0.074 13.1 0.6 1.4 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Snapin_Pallidin PF14712.6 PIK62224.1 - 0.058 13.8 3.6 0.11 12.9 3.6 1.4 1 0 0 1 1 1 0 Snapin/Pallidin Lactococcin PF04369.13 PIK62224.1 - 0.092 12.9 0.1 0.33 11.1 0.1 1.9 2 0 0 2 2 2 0 Lactococcin-like family V_ATPase_I PF01496.19 PIK62224.1 - 0.1 10.5 6.2 0.12 10.2 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5593 PF18007.1 PIK62224.1 - 0.17 12.6 0.1 0.43 11.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) DUF4363 PF14276.6 PIK62224.1 - 0.86 9.7 8.2 2.2 8.4 4.7 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4363) RRP36 PF06102.12 PIK62224.1 - 1.6 8.6 12.6 4.5 7.2 11.6 2.0 1 1 0 1 1 1 0 rRNA biogenesis protein RRP36 TMPIT PF07851.13 PIK62224.1 - 8.8 5.5 8.3 11 5.2 7.6 1.4 1 1 0 1 1 1 0 TMPIT-like protein UPAR_LY6_2 PF16975.5 PIK62225.1 - 3.1e-16 59.5 7.8 3.6e-16 59.3 7.8 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 Peptidase_C2 PF00648.21 PIK62226.1 - 9.5e-42 143.0 0.0 1.4e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 PIK62226.1 - 9.7e-13 48.6 2.9 3.6e-06 27.3 0.2 3.7 2 2 1 3 3 3 3 Calpain large subunit, domain III DUF2552 PF10827.8 PIK62226.1 - 0.14 12.3 0.5 0.56 10.4 0.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2552) MIT PF04212.18 PIK62227.1 - 1.7e-14 53.6 13.0 3.1e-10 39.9 3.2 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 PIK62227.1 - 0.067 13.0 7.2 1.1 9.2 0.9 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Q_salvage PF10343.9 PIK62227.1 - 0.13 11.8 0.5 0.18 11.4 0.5 1.1 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family Use1 PF09753.9 PIK62227.1 - 0.13 11.9 3.6 0.2 11.3 3.6 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 TPR_7 PF13176.6 PIK62227.1 - 0.15 12.1 1.4 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 PIK62227.1 - 0.4 10.9 11.5 0.77 10.0 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 PIK62227.1 - 1.6 9.1 6.1 9.3 6.8 0.3 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_29 PF00777.18 PIK62228.1 - 1e-62 212.0 0.2 1.2e-62 211.8 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) zf-C2H2_2 PF12756.7 PIK62229.1 - 1.7e-20 73.3 1.2 2.9e-20 72.5 0.1 1.9 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 PIK62230.1 - 4.8e-11 42.7 13.9 8.6e-06 25.9 9.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK62230.1 - 2.3e-06 27.8 13.0 2.4e-06 27.8 6.7 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK62230.1 - 1.4e-05 25.3 7.1 0.003 17.9 7.8 2.2 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 PIK62230.1 - 0.0014 19.3 7.1 0.019 15.8 2.4 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-LYAR PF08790.11 PIK62230.1 - 0.0059 16.5 5.9 1 9.3 0.2 2.6 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-DBF PF07535.12 PIK62230.1 - 0.01 16.0 5.2 0.16 12.1 1.5 2.5 2 0 0 2 2 2 0 DBF zinc finger THAP PF05485.12 PIK62230.1 - 0.19 12.7 5.4 0.41 11.6 5.4 1.6 1 1 0 1 1 1 0 THAP domain AKAP95 PF04988.12 PIK62230.1 - 0.19 11.9 10.4 1.1 9.5 0.2 2.2 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 PIK62230.1 - 0.87 10.2 10.3 0.11 12.9 4.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF4642 PF15484.6 PIK62230.1 - 7.5 6.8 13.0 2.2 8.5 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4642) zf-H2C2_2 PF13465.6 PIK62230.1 - 8 7.1 9.3 8.3 7.0 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger double domain HEAT_EZ PF13513.6 PIK62231.1 - 0.04 14.4 2.8 54 4.4 0.0 6.0 5 0 0 5 5 5 0 HEAT-like repeat Stevor PF17410.2 PIK62231.1 - 0.52 9.8 3.5 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame RTP1_C1 PF10363.9 PIK62231.1 - 0.97 9.6 8.3 0.79 9.9 0.1 4.5 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 FAT PF02259.23 PIK62232.1 - 1.2e-58 199.0 9.4 1.2e-58 199.0 9.4 1.9 3 0 0 3 3 3 1 FAT domain TPR_2 PF07719.17 PIK62232.1 - 0.0096 16.0 0.3 0.079 13.1 0.3 2.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 PIK62232.1 - 0.025 14.9 0.1 0.17 12.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 PIK62232.1 - 0.048 13.7 0.7 1 9.6 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PI3_PI4_kinase PF00454.27 PIK62233.1 - 2.1e-23 83.5 0.0 4.1e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 PIK62233.1 - 6e-07 29.2 0.0 1.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 FATC domain PAS_9 PF13426.7 PIK62234.1 - 1.6e-13 50.8 0.0 1.9e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 PIK62234.1 - 7.5e-06 26.1 0.0 1.1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 PIK62234.1 - 9.7e-05 22.3 0.0 0.00012 22.1 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 PIK62234.1 - 0.0002 21.6 0.0 0.00024 21.3 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 PIK62234.1 - 0.00022 21.2 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 PAS domain DUF5375 PF17345.2 PIK62234.1 - 0.046 13.6 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5375) Ion_trans PF00520.31 PIK62236.1 - 1.1e-26 93.5 1.0 1.6e-26 93.1 1.0 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 PIK62236.1 - 1e-12 47.9 0.0 2.4e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 PIK62236.1 - 2.2e-12 46.7 0.2 2.2e-12 46.7 0.2 1.9 2 0 0 2 2 2 1 Ion channel IRK PF01007.20 PIK62236.1 - 0.05 13.4 1.0 0.095 12.5 1.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain EAF PF09816.9 PIK62237.1 - 1.1e-21 77.1 0.0 1.1e-21 77.1 0.0 2.7 3 0 0 3 3 3 1 RNA polymerase II transcription elongation factor BSP_II PF05432.11 PIK62237.1 - 0.17 11.6 31.3 0.26 11.0 31.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) LAP1C PF05609.12 PIK62237.1 - 0.78 8.8 15.0 1.5 7.8 15.0 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 PIK62237.1 - 1.3 7.2 17.0 2.2 6.5 17.0 1.3 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 PIK62237.1 - 2.2 7.2 18.5 4.1 6.3 18.5 1.4 1 0 0 1 1 1 0 Solute carrier family 12 DUF2052 PF09747.9 PIK62237.1 - 2.5 8.2 20.4 0.22 11.7 15.7 1.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ABC2_membrane_3 PF12698.7 PIK62237.1 - 4 6.4 13.2 5.3 6.0 13.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Menin PF05053.13 PIK62237.1 - 5.6 5.2 15.1 8.8 4.5 15.1 1.3 1 0 0 1 1 1 0 Menin NPR3 PF03666.13 PIK62237.1 - 5.9 5.6 17.7 12 4.5 17.7 1.6 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 PIK62237.1 - 6 5.3 22.8 10 4.5 22.8 1.3 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 PIK62237.1 - 9.2 3.9 13.8 13 3.4 13.8 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CLP1_N PF16573.5 PIK62238.1 - 2.3e-20 72.6 0.1 3.4e-20 72.1 0.1 1.2 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Glucos_trans_II PF14264.6 PIK62238.1 - 0.0025 17.2 0.6 0.0028 17.1 0.6 1.0 1 0 0 1 1 1 1 Glucosyl transferase GtrII CLP1_P PF16575.5 PIK62239.1 - 9.6e-28 97.3 0.0 1.4e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 PIK62239.1 - 7.3e-06 26.1 0.0 1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor MMR_HSR1 PF01926.23 PIK62239.1 - 0.0005 20.1 0.0 0.00073 19.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 PIK62239.1 - 0.00075 19.3 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 PIK62239.1 - 0.00081 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.23 PIK62239.1 - 0.0015 18.6 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 PIK62239.1 - 0.007 16.8 0.0 0.0081 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 PIK62239.1 - 0.059 12.9 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Roc PF08477.13 PIK62239.1 - 0.073 13.3 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 PIK62239.1 - 0.11 13.0 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter TniB PF05621.11 PIK62239.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein AAA_35 PF14516.6 PIK62239.1 - 0.13 11.1 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.29 PIK62239.1 - 0.17 12.3 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 PIK62239.1 - 0.18 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 PIK62239.1 - 0.19 12.3 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 PIK62240.1 - 1.9e-31 109.3 0.0 2.4e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 PIK62240.1 - 5.2e-13 49.4 0.0 7.2e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 DUF4600 PF15372.6 PIK62241.1 - 2e-33 115.6 13.0 2e-33 115.6 13.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4600) PspA_IM30 PF04012.12 PIK62241.1 - 0.0025 17.4 14.9 0.0087 15.7 14.9 1.8 1 1 0 1 1 1 1 PspA/IM30 family KELK PF15796.5 PIK62241.1 - 0.0032 17.9 4.0 0.0032 17.9 4.0 3.2 1 1 2 3 3 3 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF842 PF05811.13 PIK62241.1 - 0.039 13.7 7.1 0.046 13.4 3.1 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Egg_lysin PF01303.17 PIK62241.1 - 0.13 12.5 1.8 0.19 11.9 1.0 1.7 1 1 0 1 1 1 0 Egg lysin (Sperm-lysin) Uso1_p115_C PF04871.13 PIK62241.1 - 0.44 10.9 23.2 1.6 9.1 4.3 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4200 PF13863.6 PIK62241.1 - 0.5 10.8 28.3 0.58 10.6 13.7 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) Glucan_synthase PF02364.15 PIK62241.1 - 0.62 8.2 5.9 0.77 7.8 5.9 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase component DUF1664 PF07889.12 PIK62241.1 - 0.67 10.0 11.0 1.7 8.7 0.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Stn1 PF10451.9 PIK62241.1 - 1.4 7.8 7.1 1.9 7.4 7.1 1.3 1 0 0 1 1 1 0 Telomere regulation protein Stn1 DHR10 PF18595.1 PIK62241.1 - 2.2 8.4 26.6 0.096 12.7 2.8 3.3 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 PIK62241.1 - 3.1 7.1 15.5 16 4.8 15.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HAUS-augmin3 PF14932.6 PIK62241.1 - 5 6.6 26.7 3 7.3 11.1 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Golgin_A5 PF09787.9 PIK62241.1 - 5.7 6.3 24.2 4.8 6.5 21.7 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 PIK62241.1 - 6 6.3 16.3 12 5.4 16.3 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit CREPT PF16566.5 PIK62241.1 - 9.6 6.4 19.0 3.5 7.8 5.0 2.9 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour RWD PF05773.22 PIK62242.1 - 8.3e-15 55.1 1.1 2.1e-14 53.8 0.1 2.1 2 2 0 2 2 2 1 RWD domain DUF1115 PF06544.12 PIK62242.1 - 1.6e-14 54.2 0.3 5.1e-14 52.6 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1115) BppL_N PF18338.1 PIK62244.1 - 2.1e-19 68.4 82.1 0.00033 20.3 0.3 18.6 18 1 1 19 19 19 12 Lower baseplate protein N-terminal domain EPTP PF03736.17 PIK62244.1 - 7.9e-17 61.0 4.4 0.0023 17.9 0.0 6.2 5 0 0 5 5 5 4 EPTP domain Sipho_Gp157 PF05565.11 PIK62244.1 - 0.003 17.6 0.3 0.7 9.9 0.1 2.8 3 0 0 3 3 3 2 Siphovirus Gp157 Peptidase_C30 PF05409.13 PIK62244.1 - 1.2 8.4 10.1 1.1 8.4 0.1 3.4 5 0 0 5 5 5 0 Coronavirus endopeptidase C30 DUF445 PF04286.12 PIK62245.1 - 9.9e-07 28.9 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF445) DUF2863 PF11062.8 PIK62245.1 - 0.075 11.4 11.4 5.3 5.3 0.6 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF2863) DUF826 PF05696.11 PIK62245.1 - 0.1 12.7 35.6 15 5.7 0.4 9.2 1 1 5 6 6 6 0 Protein of unknown function (DUF826) Sec15 PF04091.12 PIK62245.1 - 0.27 10.6 15.8 2.1 7.7 0.7 4.4 1 1 2 3 3 3 0 Exocyst complex subunit Sec15-like Peroxin-3 PF04882.12 PIK62245.1 - 0.47 9.4 17.7 5.1 6.0 3.6 3.1 1 1 1 2 2 2 0 Peroxin-3 CelTOS PF18659.1 PIK62245.1 - 5.8 7.4 12.0 23 5.4 1.8 4.1 1 1 2 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites DUF2783 PF10932.8 PIK62246.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) TRAP_alpha PF03896.16 PIK62246.1 - 0.23 10.6 1.1 0.38 9.9 1.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RVT_1 PF00078.27 PIK62247.1 - 1.1e-26 93.7 0.1 1.4e-26 93.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 PIK62248.1 - 1.1e-12 47.6 0.4 2.4e-12 46.5 0.4 1.6 1 0 0 1 1 1 1 SCAN domain Retrotrans_gag PF03732.17 PIK62248.1 - 0.023 15.0 0.0 1.9 8.8 0.0 2.4 2 1 0 2 2 2 0 Retrotransposon gag protein ELK PF03789.13 PIK62248.1 - 0.11 12.7 0.6 0.28 11.3 0.6 1.7 1 0 0 1 1 1 0 ELK domain Marek_A PF02124.15 PIK62249.1 - 0.024 14.5 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A Pkinase PF00069.25 PIK62250.1 - 6.6e-48 163.4 0.0 7.6e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62250.1 - 3.8e-31 108.3 0.0 4.6e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 PIK62250.1 - 0.0026 17.4 0.1 0.35 10.4 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 PIK62250.1 - 0.034 13.7 0.0 0.068 12.7 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.14 PIK62250.1 - 0.039 13.3 0.0 0.069 12.5 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 PIK62250.1 - 0.055 12.2 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Presenilin PF01080.17 PIK62251.1 - 7.9 5.1 7.3 8.7 5.0 7.3 1.1 1 0 0 1 1 1 0 Presenilin NACHT PF05729.12 PIK62252.1 - 1e-07 32.0 0.0 2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NLRC4_HD PF17889.1 PIK62252.1 - 0.059 13.7 0.0 0.23 11.8 0.0 2.1 1 0 0 1 1 1 0 NLRC4 helical domain CLIP PF12032.8 PIK62252.1 - 0.17 12.2 0.8 13 6.2 0.1 3.6 3 1 0 3 3 3 0 Regulatory CLIP domain of proteinases Chal_sti_synt_N PF00195.19 PIK62253.1 - 0.037 13.5 0.0 0.048 13.1 0.0 1.1 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain SET PF00856.28 PIK62254.1 - 7e-10 39.6 1.1 2.3e-09 37.8 1.1 1.7 1 1 0 1 1 1 1 SET domain zf-Di19 PF05605.12 PIK62255.1 - 1.4e-05 25.2 2.5 0.0027 18.0 0.3 2.7 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 PIK62255.1 - 0.023 15.5 13.9 0.21 12.5 0.8 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger OrsD PF12013.8 PIK62255.1 - 0.042 14.3 2.0 8.6 6.8 0.0 2.9 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 PIK62255.1 - 0.22 11.3 4.6 0.064 13.0 0.7 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Ldl_recept_b PF00058.17 PIK62256.1 - 3e-22 78.8 4.3 5.5e-14 52.4 0.1 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK62256.1 - 0.037 13.6 0.1 0.63 9.6 0.0 2.2 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_a PF00057.18 PIK62257.1 - 7.1e-37 125.3 80.5 7.4e-13 48.5 13.0 5.2 5 1 0 5 5 5 4 Low-density lipoprotein receptor domain class A EGF_CA PF07645.15 PIK62257.1 - 3.6e-09 36.7 6.4 3.6e-09 36.7 6.4 6.3 2 1 2 4 4 4 1 Calcium-binding EGF domain cEGF PF12662.7 PIK62257.1 - 8.3e-06 25.6 9.1 0.00011 22.0 1.0 5.5 7 0 0 7 7 7 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK62257.1 - 0.0014 18.8 5.3 0.0014 18.8 5.3 5.2 2 1 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK62257.1 - 0.022 14.9 1.3 0.022 14.9 1.3 6.3 4 2 0 4 4 4 0 EGF domain PRKCSH-like PF12999.7 PIK62257.1 - 3.3 7.5 50.7 0.4 10.5 5.3 3.5 1 1 2 3 3 3 0 Glucosidase II beta subunit-like Ldl_recept_b PF00058.17 PIK62258.1 - 1.9e-23 82.6 4.7 2.8e-13 50.1 0.1 3.6 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK62258.1 - 0.0069 16.0 0.3 0.14 11.7 0.1 2.0 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 PIK62259.1 - 2e-22 79.4 8.1 5.3e-13 49.2 0.1 5.2 5 0 0 5 5 5 3 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.15 PIK62259.1 - 2.1e-09 37.4 5.0 2.1e-09 37.4 5.0 3.5 2 1 1 3 3 2 1 Calcium-binding EGF domain Ldl_recept_a PF00057.18 PIK62259.1 - 4.1e-06 26.9 4.5 4.1e-06 26.9 4.5 2.8 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK62259.1 - 0.0025 17.7 0.5 0.0025 17.7 0.5 3.6 4 0 0 4 4 4 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK62259.1 - 0.0038 17.5 2.4 0.0038 17.5 2.4 3.3 1 1 1 3 3 3 1 Coagulation Factor Xa inhibitory site EGF PF00008.27 PIK62259.1 - 0.029 14.7 2.2 0.029 14.7 2.2 4.8 3 2 2 5 5 5 0 EGF-like domain EGF_3 PF12947.7 PIK62259.1 - 0.045 13.9 2.1 0.045 13.9 2.1 3.2 2 2 1 3 3 3 0 EGF domain SGL PF08450.12 PIK62259.1 - 0.046 13.3 0.4 1.7 8.2 0.0 2.8 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region EGF_CA PF07645.15 PIK62260.1 - 1e-08 35.2 6.0 1e-08 35.2 6.0 3.7 3 2 0 3 3 3 1 Calcium-binding EGF domain Ldl_recept_a PF00057.18 PIK62260.1 - 2.7e-07 30.7 4.6 2.7e-07 30.7 4.6 3.3 2 1 2 4 4 4 1 Low-density lipoprotein receptor domain class A cEGF PF12662.7 PIK62260.1 - 2.5e-06 27.3 9.5 1.4e-05 24.9 1.1 4.4 4 1 0 4 4 4 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK62260.1 - 0.00018 21.7 2.3 0.00018 21.7 2.3 4.1 1 1 1 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 PIK62260.1 - 0.16 12.1 0.5 0.16 12.1 0.5 3.6 4 1 0 4 4 4 0 MSP1 EGF domain 1 Ldl_recept_b PF00058.17 PIK62261.1 - 4.3e-23 81.5 3.0 4.6e-13 49.4 0.2 3.3 3 1 0 3 3 3 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK62261.1 - 0.029 13.9 0.2 0.35 10.4 0.1 2.0 1 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_a PF00057.18 PIK62262.1 - 8.9e-41 137.8 77.5 6.9e-13 48.6 11.7 5.2 5 1 0 5 5 5 4 Low-density lipoprotein receptor domain class A EGF_CA PF07645.15 PIK62262.1 - 3.2e-09 36.8 6.6 3.2e-09 36.8 6.6 6.6 2 1 2 4 4 4 1 Calcium-binding EGF domain cEGF PF12662.7 PIK62262.1 - 2.3e-06 27.4 8.6 2.8e-05 24.0 0.8 6.1 7 1 0 7 7 7 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 PIK62262.1 - 0.0016 18.7 5.1 0.0016 18.7 5.1 5.8 3 2 1 4 4 4 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 PIK62262.1 - 0.023 14.9 1.3 0.023 14.9 1.3 6.7 3 2 2 5 5 5 0 EGF domain SBBP PF06739.11 PIK62264.1 - 0.03 14.3 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 Beta-propeller repeat NHL PF01436.21 PIK62264.1 - 0.057 13.5 0.0 49 4.2 0.0 4.1 4 0 0 4 4 4 0 NHL repeat Fibrinogen_C PF00147.18 PIK62265.1 - 3.4e-26 92.4 1.2 3.4e-26 92.4 1.2 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK62265.1 - 1.3e-06 28.5 14.3 2.1e-06 27.9 14.3 1.3 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Big_3_2 PF12245.8 PIK62265.1 - 0.084 13.1 0.4 0.89 9.8 0.1 2.3 1 1 1 2 2 2 0 Bacterial Ig-like domain Calcyon PF06387.11 PIK62265.1 - 0.15 12.0 3.0 1.9 8.5 0.4 2.5 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) Fibrinogen_C PF00147.18 PIK62267.1 - 5.6e-25 88.4 0.2 1.1e-24 87.5 0.2 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TIL PF01826.17 PIK62267.1 - 1.9e-06 28.0 15.1 1.9e-06 28.0 15.1 3.2 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 PIK62267.1 - 7.3e-06 25.8 16.4 7.3e-06 25.8 16.4 3.1 3 0 0 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK62267.1 - 3.8e-05 23.8 7.3 3.8e-05 23.8 7.3 4.8 3 2 1 4 4 4 1 EGF domain EGF_MSP1_1 PF12946.7 PIK62267.1 - 0.31 11.1 26.0 0.081 13.0 4.1 3.7 3 0 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK62268.1 - 1.1e-31 110.3 5.6 1.3e-31 110.1 5.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SH3_1 PF00018.28 PIK62269.1 - 1.6e-17 62.8 0.0 2.2e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 PIK62269.1 - 4.1e-12 45.6 0.0 5.3e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 PIK62269.1 - 1e-09 38.1 0.0 1.3e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 PIK62269.1 - 0.02 15.1 0.1 0.032 14.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain Pkinase_Tyr PF07714.17 PIK62270.1 - 6.5e-85 284.5 0.0 7.2e-85 284.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62270.1 - 2.8e-41 141.7 0.0 3.1e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 PIK62270.1 - 0.0036 17.2 0.0 0.0091 15.9 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 PIK62270.1 - 0.0039 16.2 0.0 0.0058 15.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK62270.1 - 0.0082 15.5 0.0 0.015 14.7 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 PIK62271.1 - 1.5e-93 312.8 0.0 2.3e-93 312.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62271.1 - 4.4e-49 167.2 0.0 8.7e-49 166.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 PIK62271.1 - 5.4e-19 68.1 0.2 1.2e-18 66.9 0.2 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 PIK62271.1 - 5e-13 48.4 0.1 1.1e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK62271.1 - 1.4e-09 37.7 0.2 3.4e-09 36.4 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK62271.1 - 1.8e-09 37.2 0.0 3.7e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Haspin_kinase PF12330.8 PIK62271.1 - 1.9e-06 27.1 0.0 2.2e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 PIK62271.1 - 0.009 15.4 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK62271.1 - 0.06 13.3 0.0 0.56 10.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family B2 PF11473.8 PIK62271.1 - 0.17 11.7 0.1 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 RNA binding protein B2 Organ_specific PF10950.8 PIK62271.1 - 0.27 12.0 2.7 3.3 8.4 1.3 2.4 2 0 0 2 2 2 0 Organ specific protein Lectin_C PF00059.21 PIK62272.1 - 1.3e-19 70.9 0.2 1.9e-19 70.4 0.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain F5_F8_type_C PF00754.25 PIK62272.1 - 7.7e-10 39.0 0.0 1.3e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain EF-hand_1 PF00036.32 PIK62273.1 - 2.1e-18 64.4 0.1 0.0036 16.8 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 PIK62273.1 - 4.1e-16 57.5 0.0 0.006 16.4 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 PIK62273.1 - 4.4e-15 54.4 0.3 0.00084 18.7 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 PIK62273.1 - 3.7e-14 52.9 0.1 9.6e-07 29.2 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 PIK62273.1 - 5.4e-09 35.8 0.9 0.081 12.8 0.0 3.9 4 0 0 4 4 4 3 EF-hand domain pair VCBS PF13517.6 PIK62273.1 - 0.0056 17.2 0.9 0.029 15.0 0.4 2.2 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella SPARC_Ca_bdg PF10591.9 PIK62273.1 - 0.043 14.1 0.0 11 6.3 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 PIK62273.1 - 0.063 13.6 0.0 13 6.1 0.1 3.0 2 2 0 2 2 2 0 EF-hand domain 7tm_1 PF00001.21 PIK62274.1 - 3.1e-18 66.1 6.5 3.6e-18 65.9 6.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 PIK62274.1 - 2.9e-05 23.6 4.0 3.5e-05 23.3 4.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sugar_tr PF00083.24 PIK62276.1 - 2.3e-26 92.7 6.1 1.1e-22 80.5 0.6 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 PIK62276.1 - 6.6e-16 58.2 21.6 1.4e-12 47.2 14.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF373 PF04123.13 PIK62276.1 - 0.0011 18.5 0.5 0.0025 17.3 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF373) ACT_7 PF13840.6 PIK62276.1 - 0.046 13.5 0.2 0.14 11.9 0.2 1.8 1 0 0 1 1 1 0 ACT domain Y_phosphatase PF00102.27 PIK62277.1 - 1.7e-52 178.3 0.0 2.7e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 PIK62277.1 - 5.6e-35 119.6 15.7 6.2e-08 32.9 0.1 6.8 6 0 0 6 6 6 6 Fibronectin type III domain Shisa PF13908.6 PIK62277.1 - 5.7e-07 30.0 1.1 1.3e-06 28.8 0.6 1.8 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Arylsulfotran_N PF17425.2 PIK62277.1 - 6.2e-05 22.9 0.2 0.037 14.0 0.0 3.0 2 0 0 2 2 2 1 Arylsulfotransferase Ig-like domain Pur_ac_phosph_N PF16656.5 PIK62277.1 - 0.00022 21.7 10.2 7.6 7.2 0.0 6.1 6 1 0 6 6 5 1 Purple acid Phosphatase, N-terminal domain PTP_tm PF18861.1 PIK62277.1 - 0.0019 18.2 2.4 0.0054 16.7 0.3 2.8 3 1 0 3 3 3 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J EphA2_TM PF14575.6 PIK62277.1 - 0.0023 18.8 0.3 0.005 17.7 0.3 1.6 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Interfer-bind PF09294.10 PIK62277.1 - 0.0033 17.7 0.0 0.15 12.4 0.0 3.5 4 0 0 4 4 2 1 Interferon-alpha/beta receptor, fibronectin type III FAM176 PF14851.6 PIK62277.1 - 0.0081 15.8 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 FAM176 family WBP-1 PF11669.8 PIK62277.1 - 0.018 15.6 0.1 0.061 14.0 0.1 1.9 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF4959 PF16323.5 PIK62277.1 - 0.024 15.0 0.1 0.21 11.9 0.0 2.7 3 0 0 3 3 1 0 Domain of unknown function (DUF4959) Cadherin_C_2 PF16492.5 PIK62277.1 - 0.026 15.3 0.2 4.6 8.1 0.0 3.9 4 0 0 4 4 3 0 Cadherin cytoplasmic C-terminal Orthoreo_P10 PF07204.11 PIK62277.1 - 0.039 13.9 0.7 0.096 12.7 0.7 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Prominin PF05478.11 PIK62277.1 - 0.041 11.9 4.1 0.061 11.3 4.1 1.1 1 0 0 1 1 1 0 Prominin Ly49 PF08391.10 PIK62277.1 - 0.043 14.2 0.0 0.081 13.3 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Comm PF15957.5 PIK62277.1 - 0.051 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Commissureless TRP PF06011.12 PIK62277.1 - 0.11 11.2 0.5 0.18 10.5 0.1 1.5 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel Mucin PF01456.17 PIK62277.1 - 0.11 12.5 2.8 0.28 11.2 0.1 2.8 2 0 0 2 2 2 0 Mucin-like glycoprotein ETRAMP PF09716.10 PIK62277.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4713 PF15831.5 PIK62277.1 - 0.18 12.3 12.0 0.37 11.3 12.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Tweety PF04906.13 PIK62277.1 - 0.36 9.5 2.8 0.56 8.8 2.8 1.2 1 0 0 1 1 1 0 Tweety TMEM52 PF14979.6 PIK62277.1 - 0.42 10.5 8.0 0.097 12.6 3.7 2.1 2 0 0 2 2 2 0 Transmembrane 52 TMIE PF16038.5 PIK62277.1 - 0.75 9.7 7.7 1.7 8.6 7.7 1.5 1 0 0 1 1 1 0 TMIE protein NACHT PF05729.12 PIK62278.1 - 3.8e-08 33.4 0.0 8.4e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain GPI2 PF06432.11 PIK62278.1 - 0.00061 19.3 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase AAA_25 PF13481.6 PIK62278.1 - 0.027 14.1 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA_NucTran2_2 PF13735.6 PIK62278.1 - 0.032 14.2 0.0 0.093 12.7 0.0 1.8 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Nrap_D2 PF17403.2 PIK62278.1 - 0.065 13.0 0.6 0.14 11.9 0.2 1.7 2 0 0 2 2 2 0 Nrap protein PAP/OAS-like domain VWA PF00092.28 PIK62279.1 - 0.00048 20.4 0.1 0.0013 19.0 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain YtkA PF13115.6 PIK62279.1 - 0.018 15.6 0.0 0.05 14.2 0.0 1.8 1 0 0 1 1 1 0 YtkA-like SIT PF15330.6 PIK62279.1 - 0.046 14.2 0.0 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.6 PIK62279.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 PIK62279.1 - 0.072 14.0 0.0 0.17 12.8 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CLCA PF08434.11 PIK62280.1 - 2.6e-15 56.5 0.2 3.8e-15 55.9 0.2 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA_CoxE PF05762.14 PIK62280.1 - 0.0079 15.6 0.0 0.01 15.2 0.0 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CLCA PF08434.11 PIK62281.1 - 6.6e-40 137.1 0.0 8.1e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Sugar_tr PF00083.24 PIK62282.1 - 1.5e-22 80.1 14.0 2.3e-22 79.5 14.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 PIK62282.1 - 9.4e-18 64.2 59.3 9.1e-16 57.7 29.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily NPL PF17800.1 PIK62284.1 - 2.6e-18 66.5 0.1 5.7e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-C2H2 PF00096.26 PIK62284.1 - 9.9e-09 35.2 11.4 0.00038 20.8 1.0 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK62284.1 - 9.3e-07 29.2 8.2 0.0074 17.0 1.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK62284.1 - 8.1e-06 26.0 14.2 2.8e-05 24.3 1.3 3.2 3 0 0 3 3 3 2 Zinc-finger double domain BolA PF01722.18 PIK62284.1 - 0.00065 19.9 0.7 0.0015 18.7 0.7 1.6 1 0 0 1 1 1 1 BolA-like protein zf-C2H2_jaz PF12171.8 PIK62284.1 - 0.0037 17.5 5.0 0.049 13.9 0.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK62284.1 - 0.022 15.0 5.6 0.084 13.2 5.6 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 PIK62284.1 - 0.029 14.4 4.8 2.8 8.0 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 PIK62284.1 - 0.099 13.1 4.1 1 9.9 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 PIK62284.1 - 2.5 7.9 4.6 2.1 8.2 1.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SAND PF01342.21 PIK62285.1 - 1.4e-16 59.9 0.2 4.3e-16 58.4 0.1 1.9 2 0 0 2 2 2 1 SAND domain zf-MYND PF01753.18 PIK62285.1 - 1.6e-08 34.5 15.8 1.6e-08 34.5 15.8 2.2 2 0 0 2 2 2 1 MYND finger SBDS_C PF09377.10 PIK62285.1 - 0.1 12.6 2.0 0.2 11.7 2.0 1.4 1 0 0 1 1 1 0 SBDS protein C-terminal domain vATP-synt_E PF01991.18 PIK62285.1 - 0.3 10.5 8.2 0.48 9.8 8.2 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit MCR PF18509.1 PIK62285.1 - 0.34 10.5 0.1 0.34 10.5 0.1 2.7 2 0 0 2 2 2 0 Magnetochrome domain Transcrip_reg PF01709.20 PIK62285.1 - 0.64 9.4 7.0 0.14 11.6 3.3 1.6 2 0 0 2 2 2 0 Transcriptional regulator Ank_4 PF13637.6 PIK62286.1 - 0.013 16.1 0.2 0.22 12.1 0.1 2.6 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK62286.1 - 0.18 12.2 0.0 6.3 7.2 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) CUB PF00431.20 PIK62287.1 - 1.1e-16 61.1 0.0 2.1e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 CUB domain Shisa PF13908.6 PIK62287.1 - 0.0034 17.6 1.1 0.0037 17.5 0.1 1.5 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 PIK62287.1 - 0.0091 16.9 0.0 0.02 15.8 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 PIK62287.1 - 0.031 14.2 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family Chordopox_A13L PF05961.11 PIK62287.1 - 0.067 13.4 0.8 0.23 11.7 0.1 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein LRRC37AB_C PF14914.6 PIK62287.1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Herpes_gE PF02480.16 PIK62287.1 - 0.087 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4808 PF16066.5 PIK62287.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) TAL_FSA PF00923.19 PIK62288.1 - 9.5e-86 287.7 0.0 1.1e-85 287.4 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase zf-H2C2_2 PF13465.6 PIK62289.1 - 1.8e-149 480.1 193.6 2.4e-09 37.2 4.0 19.1 19 0 0 19 19 19 19 Zinc-finger double domain zf-C2H2 PF00096.26 PIK62289.1 - 9.4e-70 227.4 190.7 1.5e-05 25.1 2.3 19.0 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK62289.1 - 2.2e-60 196.1 170.9 0.00029 21.4 1.8 19.1 19 0 0 19 19 19 17 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK62289.1 - 9.7e-40 133.9 162.0 7.4e-06 25.8 2.2 19.3 19 0 0 19 19 19 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK62289.1 - 2.2e-29 101.1 119.8 0.0018 18.5 1.6 19.0 17 2 2 19 19 19 13 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 PIK62289.1 - 8.2e-11 41.9 97.9 3.6 7.8 0.1 18.3 17 1 1 18 18 18 7 AN1-like Zinc finger PyrI_C PF02748.15 PIK62289.1 - 3.3e-10 39.7 108.8 1.2 9.1 0.5 18.3 14 5 5 19 19 19 9 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.6 PIK62289.1 - 5.9e-10 38.8 104.7 0.0086 16.0 0.4 18.8 19 0 0 19 19 19 7 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 PIK62289.1 - 3e-05 23.7 56.4 0.011 15.5 0.2 11.5 12 0 0 12 12 11 5 zinc-finger C2H2-type zf-C2HE PF16278.5 PIK62289.1 - 6.9e-05 23.2 119.3 0.011 16.2 0.3 17.2 3 2 12 16 16 16 3 C2HE / C2H2 / C2HC zinc-binding finger Siva PF05458.12 PIK62289.1 - 0.00046 19.9 30.7 1.4 8.6 0.4 6.9 1 1 7 9 9 9 6 Cd27 binding protein (Siva) FYDLN_acid PF09538.10 PIK62289.1 - 0.0005 20.7 46.5 29 5.4 0.1 14.7 1 1 16 17 17 17 0 Protein of unknown function (FYDLN_acid) zf-Paramyx-P PF13008.7 PIK62289.1 - 0.021 14.3 66.0 0.15 11.6 1.1 12.6 10 4 4 14 14 14 0 Zinc-binding domain of Paramyxoviridae V protein zinc_ribbon_15 PF17032.5 PIK62289.1 - 0.045 14.5 81.2 0.58 10.9 2.5 9.9 3 2 5 10 10 10 0 zinc-ribbon family DUF3268 PF11672.8 PIK62289.1 - 0.087 13.2 73.7 0.42 11.0 1.2 9.3 7 3 2 10 10 10 0 zinc-finger-containing domain YyzF PF14116.6 PIK62289.1 - 0.29 11.2 91.0 9.6 6.3 0.1 17.6 14 4 4 18 18 18 0 YyzF-like protein BolA PF01722.18 PIK62289.1 - 0.88 9.9 30.0 5 7.5 0.2 8.0 6 4 3 10 10 10 0 BolA-like protein BHD_1 PF10403.9 PIK62289.1 - 1 9.2 4.8 10 6.0 0.1 4.3 4 2 0 4 4 4 0 Rad4 beta-hairpin domain 1 C1_4 PF07975.12 PIK62289.1 - 1.1 9.5 88.0 0.27 11.5 1.0 10.9 2 2 9 13 13 13 0 TFIIH C1-like domain zf-Di19 PF05605.12 PIK62289.1 - 7 7.0 113.8 1.7 9.0 5.0 13.1 2 2 14 17 17 17 0 Drought induced 19 protein (Di19), zinc-binding Syntaxin_2 PF14523.6 PIK62290.1 - 0.071 13.5 3.3 0.35 11.2 1.5 2.5 2 1 1 3 3 3 0 Syntaxin-like protein Fasciclin PF02469.22 PIK62291.1 - 3.3e-75 250.4 0.0 8e-23 81.1 0.0 4.1 4 0 0 4 4 4 4 Fasciclin domain SBF PF01758.16 PIK62292.1 - 8.5e-24 84.3 16.1 1.2e-23 83.9 15.5 1.5 1 1 0 1 1 1 1 Sodium Bile acid symporter family LAT PF15234.6 PIK62292.1 - 0.043 13.5 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 Linker for activation of T-cells Prok-E2_E PF14462.6 PIK62292.1 - 0.094 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family E Peptidase_S8 PF00082.22 PIK62293.1 - 1.8e-44 152.2 0.6 2.5e-44 151.7 0.6 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 PIK62293.1 - 4.9e-25 87.4 0.1 9.3e-25 86.5 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 PIK62293.1 - 1.2e-13 51.7 1.2 2.2e-13 50.8 1.2 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain zf-C3HC4_2 PF13923.6 PIK62294.1 - 6.5e-09 35.5 10.2 6.5e-09 35.5 10.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK62294.1 - 6.6e-08 32.3 9.5 6.6e-08 32.3 9.5 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK62294.1 - 8.1e-08 32.2 5.1 1.9e-07 31.0 4.2 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 PIK62294.1 - 5e-07 29.9 10.1 5e-07 29.9 10.1 2.9 3 1 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 PIK62294.1 - 2.8e-06 27.1 11.2 2.8e-06 27.1 11.2 3.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK62294.1 - 1.1e-05 25.3 10.9 1.1e-05 25.3 10.9 2.9 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 PIK62294.1 - 8.3e-05 22.7 9.0 8.3e-05 22.7 9.0 2.7 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 PIK62294.1 - 0.00027 20.7 10.7 0.00027 20.7 10.7 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 PIK62294.1 - 0.00037 20.7 11.3 0.00037 20.7 11.3 2.9 2 2 0 2 2 1 1 RING-H2 zinc finger domain CENP-F_leu_zip PF10473.9 PIK62294.1 - 0.0031 17.6 1.0 0.0047 17.0 1.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sina PF03145.16 PIK62294.1 - 0.0051 16.8 2.6 0.0092 15.9 2.6 1.6 1 0 0 1 1 1 1 Seven in absentia protein family zf-ANAPC11 PF12861.7 PIK62294.1 - 0.0065 16.5 7.8 0.0065 16.5 7.8 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Myosin_tail_1 PF01576.19 PIK62294.1 - 0.0077 14.1 0.5 0.0097 13.8 0.5 1.0 1 0 0 1 1 1 1 Myosin tail U-box PF04564.15 PIK62294.1 - 0.0086 16.2 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-ACC PF17848.1 PIK62294.1 - 0.01 15.9 4.1 0.041 14.0 0.4 2.9 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain CENP-F_N PF10481.9 PIK62294.1 - 0.011 15.4 0.2 0.016 14.9 0.2 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain DUF3450 PF11932.8 PIK62294.1 - 0.013 14.8 0.1 0.018 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ADIP PF11559.8 PIK62294.1 - 0.014 15.5 0.2 0.02 15.0 0.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4162 PF13732.6 PIK62294.1 - 0.014 16.1 0.2 0.023 15.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) GAS PF13851.6 PIK62294.1 - 0.025 13.9 2.0 0.056 12.8 1.5 1.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4094 PF13334.6 PIK62294.1 - 0.029 14.8 0.1 5.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) PI3K_P85_iSH2 PF16454.5 PIK62294.1 - 0.047 13.3 1.2 0.07 12.7 1.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf-Nse PF11789.8 PIK62294.1 - 0.07 13.0 3.2 0.21 11.4 3.2 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf_UBZ PF18439.1 PIK62294.1 - 0.15 11.7 4.1 1.7 8.3 0.4 3.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger FlaC_arch PF05377.11 PIK62294.1 - 0.31 11.5 1.0 3.1 8.3 0.2 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DiS_P_DiS PF06750.13 PIK62294.1 - 1.6 8.9 12.8 0.35 11.0 7.9 2.3 1 1 1 2 2 2 0 Bacterial Peptidase A24 N-terminal domain IFP_35_N PF07334.13 PIK62294.1 - 4.5 7.4 5.6 2.8 8.1 0.6 2.2 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Cation_efflux PF01545.21 PIK62295.1 - 1.5e-22 80.3 6.4 5.5e-22 78.5 6.4 1.8 1 1 0 1 1 1 1 Cation efflux family CBF PF03914.17 PIK62296.1 - 1.1e-48 165.5 1.2 1.7e-47 161.7 0.0 2.8 2 0 0 2 2 2 1 CBF/Mak21 family Adaptin_N PF01602.20 PIK62296.1 - 0.00032 19.4 4.9 0.0017 17.0 1.6 2.2 1 1 0 2 2 2 2 Adaptin N terminal region FAM110_C PF14160.6 PIK62296.1 - 0.037 15.1 0.4 0.037 15.1 0.4 4.4 4 1 0 4 4 4 0 Centrosome-associated C terminus RTP1_C1 PF10363.9 PIK62296.1 - 0.043 14.0 0.5 0.35 11.0 0.1 2.8 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 PIK62296.1 - 0.066 13.3 1.7 0.21 11.6 1.1 2.0 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DUF4790 PF16037.5 PIK62296.1 - 0.2 12.1 2.2 5.3 7.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4790) ECH_1 PF00378.20 PIK62297.1 - 4.1e-44 150.8 0.0 5.3e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK62297.1 - 0.00057 19.5 0.0 0.00095 18.7 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 PIK62297.1 - 0.02 14.9 0.3 0.057 13.4 0.0 1.9 2 0 0 2 2 2 0 Peptidase family S49 Lipase_GDSL PF00657.22 PIK62297.1 - 0.043 13.8 0.1 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase Memo PF01875.17 PIK62298.1 - 4.7e-74 248.9 0.0 6e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Katanin_con80 PF13925.6 PIK62299.1 - 2.1e-31 109.1 0.6 2.9e-31 108.6 0.6 1.2 1 0 0 1 1 1 1 con80 domain of Katanin fn3 PF00041.21 PIK62300.1 - 5.1e-143 465.8 61.8 9.8e-08 32.2 0.0 31.1 28 7 0 28 28 28 23 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK62300.1 - 8.1e-18 64.8 65.8 0.077 13.6 0.1 23.4 24 6 0 24 24 24 7 Purple acid Phosphatase, N-terminal domain ChitinaseA_N PF08329.10 PIK62300.1 - 2e-12 46.9 20.3 1.9 8.1 0.0 14.6 14 2 2 16 16 16 6 Chitinase A, N-terminal domain fn3_2 PF16893.5 PIK62300.1 - 8.9e-10 38.6 10.0 11 6.3 0.0 13.4 15 1 0 15 15 15 1 Fibronectin type III domain UPF0370 PF13980.6 PIK62300.1 - 0.0047 16.9 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0370) Interfer-bind PF09294.10 PIK62300.1 - 0.02 15.2 0.6 23 5.4 0.0 5.7 7 0 0 7 7 7 0 Interferon-alpha/beta receptor, fibronectin type III DUF1656 PF07869.12 PIK62301.1 - 6.8e-07 29.2 13.1 0.79 9.8 0.1 6.2 1 1 7 8 8 8 5 Protein of unknown function (DUF1656) FtsK_alpha PF17854.1 PIK62301.1 - 0.00033 20.8 0.0 82 3.4 0.0 5.1 1 1 4 5 5 5 0 FtsK alpha domain Filo_VP24 PF06389.11 PIK62301.1 - 0.55 9.7 7.2 17 4.8 0.2 3.8 1 1 3 4 4 4 0 Filovirus membrane-associated protein VP24 Cas1_AcylT PF07779.12 PIK62301.1 - 2.3 7.0 4.8 30 3.3 0.1 3.2 2 1 1 3 3 3 0 10 TM Acyl Transferase domain found in Cas1p DUF5040 PF16443.5 PIK62301.1 - 2.9 7.3 8.2 11 5.4 0.3 3.6 1 1 1 3 3 3 0 Domain of unknown function (DUF5040) Laminin_G_1 PF00054.23 PIK62302.1 - 2e-34 118.6 0.0 6.4e-19 68.5 0.0 2.7 3 0 0 3 3 3 2 Laminin G domain Laminin_G_2 PF02210.24 PIK62302.1 - 2.6e-33 115.3 0.0 2.1e-18 67.1 0.0 2.5 2 0 0 2 2 2 2 Laminin G domain fn3 PF00041.21 PIK62302.1 - 4.8e-33 113.3 12.0 7.9e-08 32.5 0.0 7.6 7 1 0 7 7 7 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK62302.1 - 3.3e-13 50.0 9.3 0.066 13.8 0.0 7.3 7 1 0 7 7 7 3 Purple acid Phosphatase, N-terminal domain Laminin_G_3 PF13385.6 PIK62302.1 - 2.2e-06 27.9 0.0 0.0069 16.5 0.0 2.7 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily PhoD_N PF16655.5 PIK62302.1 - 0.03 14.8 0.1 8.9 6.9 0.0 2.8 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain Laminin_EGF PF00053.24 PIK62303.1 - 2.5e-86 283.6 191.3 2.4e-11 43.6 11.6 10.6 9 1 1 10 10 10 10 Laminin EGF domain Laminin_N PF00055.17 PIK62303.1 - 4.4e-23 82.1 0.0 4.4e-23 82.1 0.0 4.6 6 1 0 6 6 6 1 Laminin N-terminal (Domain VI) Laminin_G_3 PF13385.6 PIK62303.1 - 7e-10 39.2 0.7 1.7e-09 38.0 0.7 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily fn3 PF00041.21 PIK62303.1 - 0.086 13.2 0.1 0.2 12.0 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Laminin_G_2 PF02210.24 PIK62303.1 - 0.14 12.8 0.1 0.61 10.7 0.0 1.9 2 0 0 2 2 2 0 Laminin G domain IDO PF01231.18 PIK62304.1 - 0.0069 15.2 0.0 0.034 13.0 0.0 1.8 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase CDC4_D PF16856.5 PIK62304.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain Kinesin PF00225.23 PIK62305.1 - 3.2e-23 82.2 0.0 3.5e-23 82.1 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain HTH_7 PF02796.15 PIK62305.1 - 0.018 15.1 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF89 PF01937.19 PIK62305.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 Myelin-PO_C PF10570.9 PIK62306.1 - 0.00083 19.7 0.0 10 6.6 0.0 4.6 4 0 0 4 4 4 2 Myelin-PO cytoplasmic C-term p65 binding region START PF01852.19 PIK62307.1 - 8e-10 38.5 0.1 1.1e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 START domain C2 PF00168.30 PIK62309.1 - 8.2e-24 83.9 0.0 7.6e-13 48.6 0.0 2.2 2 0 0 2 2 2 2 C2 domain DOCK-C2 PF14429.6 PIK62309.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins PI3K_C2 PF00792.24 PIK62309.1 - 0.14 12.0 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 adh_short PF00106.25 PIK62311.1 - 1.3e-08 34.6 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 PIK62311.1 - 3.8e-05 23.7 0.2 5.3e-05 23.2 0.2 1.1 1 0 0 1 1 1 1 KR domain ApbA PF02558.16 PIK62311.1 - 0.0026 17.4 0.1 0.0034 17.0 0.1 1.1 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 PIK62311.1 - 0.011 15.6 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 PIK62311.1 - 0.022 13.9 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PRA1 PF03208.19 PIK62311.1 - 0.042 13.5 0.7 0.049 13.3 0.7 1.2 1 0 0 1 1 1 0 PRA1 family protein NAD_Gly3P_dh_N PF01210.23 PIK62311.1 - 0.052 13.5 0.0 0.067 13.2 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Epimerase PF01370.21 PIK62311.1 - 0.055 12.9 0.0 0.066 12.7 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 PIK62311.1 - 0.068 12.7 0.0 0.084 12.4 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PqiA PF04403.13 PIK62311.1 - 0.079 12.8 1.8 0.096 12.5 1.8 1.2 1 0 0 1 1 1 0 Paraquat-inducible protein A GDP_Man_Dehyd PF16363.5 PIK62311.1 - 0.15 11.4 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 PIK62312.1 - 1.5e-31 109.4 0.1 2.1e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK62312.1 - 4.2e-17 62.5 0.0 5.8e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF3890 PF13029.6 PIK62312.1 - 0.012 16.1 0.1 0.021 15.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3890) Tubulin_C PF03953.17 PIK62313.1 - 4.8e-42 143.1 0.0 6.6e-42 142.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Sipho_Gp157 PF05565.11 PIK62314.1 - 0.00055 20.0 3.5 0.0008 19.5 3.5 1.4 1 0 0 1 1 1 1 Siphovirus Gp157 YabA PF06156.13 PIK62314.1 - 0.012 16.2 3.9 0.048 14.3 2.5 2.2 2 0 0 2 2 2 0 Initiation control protein YabA HD_2 PF12917.7 PIK62314.1 - 0.028 14.2 1.3 0.047 13.5 1.3 1.4 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Tropomyosin_1 PF12718.7 PIK62314.1 - 0.029 14.5 4.4 0.039 14.1 3.9 1.5 1 1 0 1 1 1 0 Tropomyosin like Transposase_22 PF02994.14 PIK62314.1 - 0.23 11.7 3.4 0.73 10.1 0.9 2.7 2 2 0 2 2 2 0 L1 transposable element RBD-like domain DUF1664 PF07889.12 PIK62314.1 - 0.29 11.2 5.4 0.23 11.5 2.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med9 PF07544.13 PIK62314.1 - 0.63 10.2 5.6 3 8.0 5.4 2.2 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4200 PF13863.6 PIK62314.1 - 0.64 10.4 9.3 3.3 8.1 2.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Exo_endo_phos_2 PF14529.6 PIK62316.1 - 6.6e-10 38.9 0.2 2.2e-09 37.2 0.2 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62316.1 - 8e-10 38.6 0.2 1.3e-09 37.9 0.2 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Macoilin PF09726.9 PIK62317.1 - 0.082 11.5 6.0 0.1 11.1 6.0 1.1 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 PIK62317.1 - 1.5 8.6 12.0 2 8.2 12.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Bud13 PF09736.9 PIK62317.1 - 3.3 8.1 12.3 2.2 8.7 10.3 1.7 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex DUF4706 PF15797.5 PIK62318.1 - 2.5e-26 92.3 1.3 2.5e-26 92.3 1.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4706) HMG_box_5 PF14887.6 PIK62318.1 - 0.064 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 GREB1 PF15782.5 PIK62318.1 - 7.3 3.6 13.4 12 2.8 13.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AMOP PF03782.17 PIK62319.1 - 8.4e-19 68.1 0.6 1e-18 67.8 0.6 1.1 1 0 0 1 1 1 1 AMOP domain F-box-like PF12937.7 PIK62320.1 - 1.6e-12 47.1 1.7 1.6e-12 47.1 1.7 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 PIK62320.1 - 2.5e-06 27.2 1.5 6.3e-06 25.9 1.5 1.7 1 0 0 1 1 1 1 F-box domain Rbsn PF11464.8 PIK62320.1 - 0.1 12.3 0.2 0.81 9.5 0.0 2.2 1 1 1 2 2 2 0 Rabenosyn Rab binding domain STAS PF01740.21 PIK62321.1 - 0.18 11.4 0.4 0.33 10.6 0.3 1.5 1 1 0 1 1 1 0 STAS domain 7tm_3 PF00003.22 PIK62322.1 - 2.8e-51 174.5 20.0 4.2e-51 174.0 20.0 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 PIK62322.1 - 1.6e-11 44.0 0.0 2.3e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lectin_C PF00059.21 PIK62322.1 - 1.7e-06 28.7 0.0 3.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 PIK62322.1 - 0.19 11.3 1.7 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like PNMA PF14893.6 PIK62323.1 - 4.6e-24 85.4 0.0 5.7e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 PNMA RT_RNaseH_2 PF17919.1 PIK62324.1 - 2.4e-32 110.9 0.0 5.1e-32 109.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62324.1 - 9.7e-30 103.0 0.0 2.1e-29 101.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62324.1 - 1.2e-17 64.1 0.1 5.2e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 PIK62324.1 - 0.0016 19.1 0.0 0.005 17.5 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK62324.1 - 0.0078 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 PIK62324.1 - 0.049 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Mce4_CUP1 PF11887.8 PIK62324.1 - 0.12 11.8 0.0 0.42 10.0 0.0 1.8 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative rve PF00665.26 PIK62325.1 - 2.8e-23 82.4 0.0 4.1e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK62325.1 - 3.5e-07 29.9 0.3 1.1e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain ANF_receptor PF01094.28 PIK62327.1 - 6e-07 28.9 0.1 7.7e-07 28.5 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NTR PF01759.21 PIK62328.1 - 0.031 14.1 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 UNC-6/NTR/C345C module DUF902 PF06001.13 PIK62329.1 - 0.017 15.6 0.0 0.017 15.6 0.0 8.5 9 1 1 10 10 10 0 Domain of Unknown Function (DUF902) SSF PF00474.17 PIK62330.1 - 1.2e-41 142.9 32.5 1.2e-41 142.9 32.5 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family SSF PF00474.17 PIK62331.1 - 2.8e-06 26.4 5.7 3.6e-06 26.1 5.7 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family YpmT PF17431.2 PIK62331.1 - 5.5 7.1 6.3 1.1 9.4 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized YmpT-like SSF PF00474.17 PIK62332.1 - 7.2e-19 67.9 14.6 7.2e-19 67.9 14.6 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family OAD_gamma PF04277.13 PIK62332.1 - 0.29 11.8 0.1 0.29 11.8 0.1 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SSF PF00474.17 PIK62333.1 - 5.5e-42 144.1 30.2 5.5e-42 144.1 30.2 1.3 2 0 0 2 2 2 1 Sodium:solute symporter family SSF PF00474.17 PIK62334.1 - 4e-16 58.9 0.5 4e-16 58.9 0.5 2.6 2 1 1 3 3 3 2 Sodium:solute symporter family LAB_N PF07578.11 PIK62334.1 - 0.011 15.7 2.8 0.15 12.2 0.0 2.9 3 0 0 3 3 3 0 Lipid A Biosynthesis N-terminal domain Lipoxygenase PF00305.19 PIK62335.1 - 7e-72 242.9 0.0 2.2e-71 241.2 0.0 1.6 1 1 1 2 2 2 1 Lipoxygenase PLAT PF01477.23 PIK62335.1 - 2.2e-14 54.0 0.5 4.4e-14 53.0 0.5 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Telomere_Sde2_2 PF13297.6 PIK62336.1 - 8.8e-26 89.3 1.2 1.8e-25 88.3 1.2 1.6 1 0 0 1 1 1 1 Telomere stability C-terminal Sde2_N_Ubi PF13019.6 PIK62336.1 - 7.2e-25 87.7 1.2 1.5e-24 86.7 1.2 1.5 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain SAP PF02037.27 PIK62336.1 - 0.074 12.8 1.2 0.18 11.6 1.2 1.7 1 1 0 1 1 1 0 SAP domain NTR PF01759.21 PIK62338.1 - 0.031 14.1 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 UNC-6/NTR/C345C module SAP PF02037.27 PIK62339.1 - 1.2e-06 28.1 1.3 1.2e-06 28.1 1.3 1.8 2 0 0 2 2 2 1 SAP domain Ish1 PF10281.9 PIK62339.1 - 0.016 15.5 0.2 0.031 14.6 0.2 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Telomere_Sde2_2 PF13297.6 PIK62339.1 - 0.033 13.8 0.1 0.075 12.7 0.1 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal ANF_receptor PF01094.28 PIK62340.1 - 7.4e-31 107.5 0.0 9.8e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK62340.1 - 1e-07 32.0 0.0 1.4e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Lectin_C PF00059.21 PIK62341.1 - 1.9e-09 38.2 0.2 3.7e-09 37.3 0.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain ANF_receptor PF01094.28 PIK62341.1 - 3.1e-09 36.4 0.1 4.6e-09 35.9 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 PIK62341.1 - 1.3e-06 28.3 2.3 1.3e-06 28.3 2.3 2.2 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR RVT_1 PF00078.27 PIK62342.1 - 3.6e-24 85.5 0.0 4.9e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 PIK62343.1 - 2.6e-06 27.9 0.0 6.4e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK62343.1 - 6.7e-05 23.4 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 PIK62343.1 - 0.024 14.9 0.0 0.056 13.8 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.23 PIK62343.1 - 5.2 7.3 16.3 0.082 13.0 6.2 2.4 2 0 0 2 2 2 0 Zinc knuckle TRADD_N PF09034.10 PIK62344.1 - 0.0053 16.8 0.4 0.038 14.0 1.0 2.2 2 0 0 2 2 2 1 TRADD, N-terminal domain Cor1 PF04803.12 PIK62344.1 - 0.019 15.2 6.2 0.23 11.7 1.8 2.9 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Cas_St_Csn2 PF16813.5 PIK62344.1 - 0.037 13.2 0.9 6.7 5.7 0.3 2.3 2 1 0 2 2 2 0 CRISPR-associated protein Csn2 subfamily St Csm2_III-A PF03750.13 PIK62344.1 - 0.044 14.6 2.3 0.11 13.4 0.4 2.4 2 0 0 2 2 2 0 Csm2 Type III-A NIBRIN_BRCT_II PF16508.5 PIK62344.1 - 0.071 13.4 0.3 2.9 8.2 0.0 2.7 2 1 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein DUF1351 PF07083.11 PIK62344.1 - 0.16 11.7 0.2 0.16 11.7 0.2 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1351) Occludin_ELL PF07303.13 PIK62344.1 - 0.68 10.7 6.7 15 6.4 0.2 3.3 2 1 1 3 3 3 0 Occludin homology domain DUF16 PF01519.16 PIK62344.1 - 2.1 8.9 6.9 6.7 7.3 4.3 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 SmAKAP PF15127.6 PIK62346.1 - 0.027 15.6 0.1 0.17 13.1 0.0 2.2 2 0 0 2 2 2 0 Small membrane A-kinase anchor protein PurA PF04845.13 PIK62347.1 - 1.8e-69 233.5 0.2 2e-68 230.0 0.2 1.9 1 1 0 1 1 1 1 PurA ssDNA and RNA-binding protein EFG_C PF00679.24 PIK62347.1 - 0.00015 21.7 0.0 0.3 11.1 0.0 2.7 2 0 0 2 2 2 2 Elongation factor G C-terminus DUF3276 PF11680.8 PIK62347.1 - 0.00056 20.0 0.1 0.41 10.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3276) Death PF00531.22 PIK62348.1 - 9e-13 48.2 1.8 1.8e-10 40.8 0.1 2.9 2 1 0 2 2 2 2 Death domain DED PF01335.21 PIK62348.1 - 1.9e-10 40.9 0.5 2e-08 34.4 0.1 2.5 3 0 0 3 3 3 2 Death effector domain HMG_box PF00505.19 PIK62348.1 - 0.38 11.2 3.6 0.19 12.2 0.7 1.9 2 0 0 2 2 2 0 HMG (high mobility group) box Peptidase_C14 PF00656.22 PIK62349.1 - 3.8e-23 82.7 0.2 7.2e-23 81.8 0.2 1.4 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 PIK62349.1 - 4.7e-09 36.4 0.1 9e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Death effector domain Thioredoxin_15 PF18403.1 PIK62349.1 - 0.045 13.7 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain DUF547 PF04784.14 PIK62350.1 - 2.1e-36 124.6 0.0 3.7e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RPN1_RPN2_N PF17781.1 PIK62351.1 - 4.9e-126 420.3 0.9 7.1e-126 419.8 0.9 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 PIK62351.1 - 1.1e-20 72.9 14.4 5.2e-08 32.9 0.1 6.9 8 0 0 8 8 8 4 Proteasome/cyclosome repeat PHP_C PF13263.6 PIK62351.1 - 0.037 13.8 0.0 0.098 12.4 0.0 1.7 1 0 0 1 1 1 0 PHP-associated RasGAP PF00616.19 PIK62351.1 - 0.11 12.2 3.3 0.26 11.0 3.3 1.6 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase IFRD PF05004.13 PIK62351.1 - 0.17 11.0 6.3 0.57 9.2 2.8 2.3 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Utp13 PF08625.11 PIK62351.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain CRA PF06589.11 PIK62351.1 - 2.2 8.4 4.8 6.6 6.9 4.8 1.7 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) RPN1_C PF18051.1 PIK62352.1 - 2.4e-32 110.7 0.1 3.8e-32 110.1 0.1 1.3 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 PIK62352.1 - 0.0012 19.1 8.7 0.067 13.6 1.0 4.0 5 0 0 5 5 5 2 Proteasome/cyclosome repeat HEAT_2 PF13646.6 PIK62352.1 - 0.0054 17.1 0.0 0.025 15.0 0.0 2.0 2 0 0 2 2 2 1 HEAT repeats DEAD_2 PF06733.15 PIK62352.1 - 0.025 14.2 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 DEAD_2 V-ATPase_C PF03223.15 PIK62353.1 - 2.7e-157 523.9 3.9 3.1e-157 523.7 3.9 1.0 1 0 0 1 1 1 1 V-ATPase subunit C TolA_bind_tri PF16331.5 PIK62353.1 - 0.13 12.4 0.1 8.9 6.5 0.0 2.9 3 0 0 3 3 3 0 TolA binding protein trimerisation RRM_1 PF00076.22 PIK62354.1 - 1.9e-20 72.4 0.0 3.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF445 PF04286.12 PIK62355.1 - 0.15 11.9 2.5 0.23 11.2 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) PNMA PF14893.6 PIK62355.1 - 0.2 11.0 2.6 8 5.7 0.3 2.1 1 1 0 2 2 2 0 PNMA CRR7 PF12095.8 PIK62355.1 - 1.8 9.1 6.9 37 4.9 0.1 3.7 4 0 0 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 RFX_DNA_binding PF02257.15 PIK62356.1 - 4.6e-33 113.7 0.1 8.4e-33 112.9 0.1 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 PIK62356.1 - 0.00088 19.7 0.0 0.0024 18.3 0.0 1.7 1 1 0 1 1 1 1 Poxvirus D5 protein-like Hirudin PF00713.17 PIK62356.1 - 0.18 12.1 8.6 0.77 10.1 1.4 2.5 2 0 0 2 2 2 0 Hirudin adh_short PF00106.25 PIK62357.1 - 7.4e-40 136.5 0.1 1e-39 136.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK62357.1 - 6.7e-22 78.2 0.0 8.6e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK62357.1 - 2.6e-06 27.5 0.8 4.4e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 PIK62357.1 - 0.00085 19.3 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding AIPR PF10592.9 PIK62357.1 - 0.0045 16.6 0.0 0.0053 16.4 0.0 1.1 1 0 0 1 1 1 1 AIPR protein Polysacc_synt_2 PF02719.15 PIK62357.1 - 0.0063 15.7 0.1 0.01 15.0 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK62357.1 - 0.0087 15.5 0.1 0.014 14.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK62357.1 - 0.011 16.0 0.1 0.032 14.5 0.1 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 PIK62357.1 - 0.062 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NACHT PF05729.12 PIK62359.1 - 2.3e-08 34.1 0.0 4.7e-08 33.1 0.0 1.5 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 PIK62359.1 - 0.002 17.8 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK62359.1 - 0.028 14.7 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 PIK62359.1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SURF6 PF04935.12 PIK62359.1 - 1.9 8.2 7.4 3.1 7.5 7.4 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 Kelch_4 PF13418.6 PIK62360.1 - 0.046 13.7 0.0 0.58 10.2 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain NACHT PF05729.12 PIK62362.1 - 2.1e-11 44.0 0.0 4.9e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 PIK62362.1 - 0.0059 16.2 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain zf-H2C2_2 PF13465.6 PIK62363.1 - 1.4e-66 218.2 132.7 9.6e-08 32.1 1.8 15.4 16 0 0 16 16 16 12 Zinc-finger double domain zf-C2H2 PF00096.26 PIK62363.1 - 1e-46 154.8 149.2 6.3e-06 26.4 4.0 14.2 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK62363.1 - 1.2e-29 100.4 143.6 0.0042 17.8 0.9 14.2 14 0 0 14 14 14 14 C2H2-type zinc finger zf-met PF12874.7 PIK62363.1 - 6.4e-06 26.4 96.5 0.0073 16.7 1.3 11.8 12 0 0 12 12 11 7 Zinc-finger of C2H2 type C1_4 PF07975.12 PIK62363.1 - 0.00047 20.3 85.2 0.038 14.2 4.5 8.7 5 3 4 9 9 9 5 TFIIH C1-like domain FYVE PF01363.21 PIK62363.1 - 0.0018 18.3 84.3 0.043 14.0 11.8 7.8 4 2 2 7 7 7 4 FYVE zinc finger zf-C2H2_6 PF13912.6 PIK62363.1 - 0.0026 17.7 127.2 0.025 14.6 0.5 14.9 14 1 0 14 14 13 8 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK62363.1 - 0.01 15.6 2.7 0.01 15.6 2.7 12.2 14 0 0 14 14 14 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK62363.1 - 0.026 14.8 2.6 0.026 14.8 2.6 13.2 14 1 0 14 14 12 0 Zinc-finger double-stranded RNA-binding BHD_1 PF10403.9 PIK62363.1 - 0.052 13.4 11.8 0.97 9.3 0.1 5.3 5 1 0 5 5 5 0 Rad4 beta-hairpin domain 1 Baculo_IE-1 PF05290.11 PIK62363.1 - 0.46 10.4 40.2 0.57 10.1 2.8 8.5 1 1 3 6 6 6 0 Baculovirus immediate-early protein (IE-0) BolA PF01722.18 PIK62363.1 - 0.47 10.8 37.0 7.4 6.9 0.6 7.7 2 1 5 7 7 7 0 BolA-like protein CLCA PF08434.11 PIK62364.1 - 7.8e-65 218.8 0.1 1.3e-64 218.1 0.1 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA_CoxE PF05762.14 PIK62364.1 - 0.078 12.4 0.1 0.27 10.6 0.1 1.8 1 1 1 2 2 2 0 VWA domain containing CoxE-like protein NKAP PF15692.5 PIK62364.1 - 0.096 13.4 0.0 0.24 12.1 0.0 1.6 1 0 0 1 1 1 0 NF-kappa-B-activating protein VWA PF00092.28 PIK62364.1 - 0.41 10.9 3.6 3.1 8.0 0.2 2.4 1 1 1 2 2 2 0 von Willebrand factor type A domain Thiolase_N PF00108.23 PIK62365.1 - 1.2e-79 267.4 0.4 3.3e-79 265.9 0.0 1.8 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 PIK62365.1 - 1.2e-52 176.7 2.2 2.5e-52 175.7 0.6 2.3 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 PIK62365.1 - 4e-07 29.9 4.6 0.00077 19.1 0.9 3.0 3 1 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 PIK62365.1 - 0.055 13.6 0.1 0.16 12.2 0.1 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GPI2 PF06432.11 PIK62366.1 - 0.1 12.0 2.8 0.51 9.7 2.8 2.0 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase NACHT PF05729.12 PIK62367.1 - 0.0066 16.4 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DAP3 PF10236.9 PIK62367.1 - 0.054 12.7 0.0 0.097 11.8 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 PIK62367.1 - 0.056 13.0 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK62367.1 - 0.067 12.9 0.1 0.6 9.9 0.0 2.2 1 1 1 2 2 2 0 P-loop containing region of AAA domain XPG_I PF00867.18 PIK62369.1 - 5.4e-25 87.6 0.0 8.3e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 PIK62369.1 - 3.2e-14 53.2 0.0 1.6e-13 51.0 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain DnaJ_CXXCXGXG PF00684.19 PIK62369.1 - 0.025 15.0 1.9 0.065 13.6 1.9 1.7 1 0 0 1 1 1 0 DnaJ central domain Anti-TRAP PF15777.5 PIK62369.1 - 0.33 10.9 1.9 0.7 9.9 1.3 1.9 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein WAC_Acf1_DNA_bd PF10537.9 PIK62370.1 - 8e-19 68.0 0.0 1.3e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DUF5097 PF17020.5 PIK62370.1 - 0.00015 22.1 0.1 0.00063 20.1 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF5097) WSD PF15613.6 PIK62371.1 - 7.9e-20 71.2 0.0 7.9e-20 71.2 0.0 5.1 5 1 0 5 5 5 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 PIK62371.1 - 4.7e-19 68.0 25.5 3.5e-11 42.8 4.6 2.8 2 0 0 2 2 2 2 PHD-finger WHIM1 PF15612.6 PIK62371.1 - 7e-09 35.0 0.3 7e-09 35.0 0.3 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD_2 PF13831.6 PIK62371.1 - 6.5e-05 22.4 8.7 0.014 14.9 0.4 2.9 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.6 PIK62371.1 - 9.1e-05 22.3 16.4 0.0025 17.7 1.0 2.8 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 zf-HC5HC2H PF13771.6 PIK62371.1 - 0.00019 21.6 13.4 0.0027 17.9 1.0 3.4 3 0 0 3 3 3 2 PHD-like zinc-binding domain C1_1 PF00130.22 PIK62371.1 - 0.0005 19.9 12.7 0.026 14.4 1.2 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 PIK62371.1 - 0.0034 17.7 7.2 0.0034 17.7 7.2 2.7 2 0 0 2 2 2 1 Ring finger domain zf-HC5HC2H_2 PF13832.6 PIK62371.1 - 0.45 10.7 13.6 1.4 9.1 2.9 2.9 2 0 0 2 2 2 0 PHD-zinc-finger like domain C1_2 PF03107.16 PIK62371.1 - 5.8 7.3 23.3 0.034 14.5 2.9 3.2 3 0 0 3 3 3 0 C1 domain 5-FTHF_cyc-lig PF01812.20 PIK62372.1 - 9.7e-31 107.1 0.0 1.8e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family V_ATPase_I PF01496.19 PIK62372.1 - 0.29 9.0 0.1 0.44 8.4 0.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 PIK62372.1 - 0.52 9.0 3.3 0.87 8.3 3.3 1.3 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 PIK62372.1 - 1.5 8.2 7.0 0.11 11.8 2.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CCDC53 PF10152.9 PIK62372.1 - 4.4 7.7 7.0 1.8 8.9 3.9 1.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex NPR3 PF03666.13 PIK62372.1 - 6.2 5.5 6.8 9.6 4.9 6.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_transf_29 PF00777.18 PIK62375.1 - 2.5e-46 158.3 0.6 2.9e-46 158.0 0.6 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) rve PF00665.26 PIK62376.1 - 0.00026 21.2 0.0 0.0013 19.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain PIF1 PF05970.14 PIK62378.1 - 4e-102 342.1 0.0 6.7e-102 341.4 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 PIK62378.1 - 4.9e-56 190.0 0.0 4.9e-56 190.0 0.0 2.4 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 PIK62378.1 - 1.1e-10 41.5 0.0 3.2e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK62378.1 - 3.5e-07 30.6 0.0 1.7e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.14 PIK62378.1 - 0.0014 18.0 0.3 0.41 9.8 0.0 2.3 2 0 0 2 2 2 2 KAP family P-loop domain Serine_rich PF08824.10 PIK62378.1 - 0.0076 16.3 3.1 0.023 14.7 3.1 1.8 1 0 0 1 1 1 1 Serine rich protein interaction domain Golgin_A5 PF09787.9 PIK62378.1 - 0.049 13.1 12.1 0.12 11.8 12.1 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 5 Fim-adh_lectin PF09222.10 PIK62378.1 - 0.092 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Fimbrial adhesin F17-AG, lectin domain ResIII PF04851.15 PIK62378.1 - 0.14 12.1 0.0 0.14 12.1 0.0 2.7 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit Phage_GPO PF05929.11 PIK62378.1 - 0.2 11.2 6.8 0.43 10.1 6.8 1.5 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TMCO5 PF14992.6 PIK62378.1 - 0.23 11.0 10.2 0.5 9.9 10.2 1.5 1 0 0 1 1 1 0 TMCO5 family DUF1366 PF07104.11 PIK62378.1 - 0.43 10.3 5.8 1.2 8.9 5.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) DUF3450 PF11932.8 PIK62378.1 - 0.94 8.7 10.0 2.5 7.3 10.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PCRF PF03462.18 PIK62378.1 - 1.8 8.4 8.0 2.1 8.2 6.3 2.0 2 0 0 2 2 2 0 PCRF domain DUF1515 PF07439.11 PIK62378.1 - 2.3 8.3 3.6 5.3 7.1 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Tho2 PF11262.8 PIK62378.1 - 2.7 7.1 10.3 5.5 6.1 8.8 2.3 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 Mod_r PF07200.13 PIK62378.1 - 3.4 7.8 16.0 0.48 10.5 11.5 1.9 2 0 0 2 2 1 0 Modifier of rudimentary (Mod(r)) protein zf-CCHC PF00098.23 PIK62380.1 - 4.9e-07 29.5 16.3 0.00077 19.4 0.2 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK62380.1 - 0.0047 16.7 10.4 0.49 10.3 5.9 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-C2H2_10 PF16588.5 PIK62380.1 - 0.021 14.6 0.8 0.021 14.6 0.8 2.7 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 PIK62380.1 - 0.025 14.4 0.3 0.025 14.4 0.3 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK62380.1 - 0.04 13.6 11.0 5.1 6.9 0.3 3.5 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 PIK62380.1 - 0.11 12.5 16.7 0.44 10.5 1.7 3.7 2 1 2 4 4 4 0 Zinc knuckle CENP-B_N PF04218.13 PIK62381.1 - 0.0088 15.7 0.0 12 5.6 0.0 3.6 2 1 2 4 4 4 2 CENP-B N-terminal DNA-binding domain FAM150 PF15129.6 PIK62381.1 - 0.048 13.8 2.3 7.9 6.7 0.0 2.9 1 1 3 4 4 4 0 FAM150 family Integrase_H2C2 PF17921.1 PIK62382.1 - 2.1e-18 66.1 0.6 2.1e-18 66.1 0.6 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK62382.1 - 8.1e-17 61.5 0.0 3.2e-16 59.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK62382.1 - 3.3e-08 33.6 0.5 1.2e-07 31.8 0.1 2.1 2 0 0 2 2 2 1 H2C2 zinc finger PHD PF00628.29 PIK62382.1 - 3.4e-05 23.7 9.1 3.4e-05 23.7 9.1 2.5 2 0 0 2 2 2 1 PHD-finger Exo_endo_phos_2 PF14529.6 PIK62383.1 - 1.4e-10 41.0 0.0 2.4e-10 40.3 0.0 1.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62383.1 - 0.00043 19.9 0.0 0.00069 19.2 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BRCT_3 PF18428.1 PIK62383.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain RVT_1 PF00078.27 PIK62384.1 - 1.1e-40 139.5 0.1 2e-40 138.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Helicase_C_4 PF13871.6 PIK62384.1 - 0.11 12.1 0.4 0.2 11.3 0.4 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue RVT_1 PF00078.27 PIK62385.1 - 1.4e-09 37.8 0.0 1.9e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Vps39_2 PF10367.9 PIK62386.1 - 7.6e-29 100.4 0.8 7.6e-29 100.4 0.8 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 PIK62386.1 - 2.5e-21 76.0 3.1 1.4e-16 60.7 0.1 4.0 4 0 0 4 4 4 2 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 PIK62386.1 - 8e-20 71.2 6.4 2.8e-09 37.0 0.2 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS CNH PF00780.22 PIK62386.1 - 1.1e-05 25.2 0.0 2.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 CNH domain DUF3887 PF13026.6 PIK62386.1 - 0.11 13.3 0.1 0.3 11.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) HCNGP PF07818.13 PIK62387.1 - 1.9e-32 111.8 0.1 6.5e-32 110.0 0.1 2.0 1 0 0 1 1 1 1 HCNGP-like protein CRAL_TRIO PF00650.20 PIK62388.1 - 0.021 14.5 0.0 2.3 7.9 0.0 2.6 3 0 0 3 3 3 0 CRAL/TRIO domain NIBRIN_BRCT_II PF16508.5 PIK62388.1 - 0.064 13.6 1.1 4.3 7.7 0.0 3.4 3 1 0 3 3 3 0 Second BRCT domain on Nijmegen syndrome breakage protein Cor1 PF04803.12 PIK62388.1 - 0.067 13.4 8.5 0.31 11.2 1.4 2.9 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Csm2_III-A PF03750.13 PIK62388.1 - 0.076 13.9 1.8 0.2 12.5 0.4 2.4 2 0 0 2 2 2 0 Csm2 Type III-A PurA PF04845.13 PIK62392.1 - 1.7e-89 298.9 0.0 2.1e-89 298.6 0.0 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein EFG_C PF00679.24 PIK62392.1 - 0.00022 21.2 0.0 0.43 10.7 0.0 2.8 3 0 0 3 3 3 2 Elongation factor G C-terminus DUF3276 PF11680.8 PIK62392.1 - 0.016 15.4 6.2 0.36 11.0 0.2 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF3276) Death PF00531.22 PIK62393.1 - 3.6e-14 52.7 0.8 3.4e-12 46.4 0.1 2.9 3 0 0 3 3 3 1 Death domain DED PF01335.21 PIK62393.1 - 2e-11 44.0 0.4 5.9e-11 42.5 0.2 1.9 2 0 0 2 2 2 1 Death effector domain ThiD2 PF17792.1 PIK62393.1 - 0.038 14.4 2.6 0.096 13.2 1.7 1.9 1 1 1 2 2 2 0 ThiD2 family AAA_2 PF07724.14 PIK62393.1 - 0.069 13.3 2.0 0.076 13.1 0.2 1.8 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) DUF2605 PF10792.9 PIK62393.1 - 0.1 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) DUF5357 PF17310.2 PIK62393.1 - 0.1 11.2 0.3 0.18 10.3 0.1 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5357) Peptidase_C14 PF00656.22 PIK62394.1 - 4.2e-19 69.5 0.4 8.7e-19 68.4 0.4 1.5 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 PIK62394.1 - 8e-11 42.1 0.1 1.4e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 Death effector domain Thioredoxin_15 PF18403.1 PIK62394.1 - 0.00018 21.5 0.0 0.00031 20.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain DUF547 PF04784.14 PIK62395.1 - 2e-36 124.7 0.0 3.2e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RPN1_RPN2_N PF17781.1 PIK62396.1 - 6.8e-51 173.5 0.1 9.1e-51 173.1 0.1 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain OSTMP1 PF09777.9 PIK62396.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Filament PF00038.21 PIK62396.1 - 0.025 14.2 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 Intermediate filament protein RPN1_RPN2_N PF17781.1 PIK62397.1 - 2.6e-43 148.6 0.3 2.6e-43 148.6 0.3 1.8 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 PIK62397.1 - 1.1e-25 88.7 17.4 6.9e-05 23.1 0.0 8.6 9 0 0 9 9 9 5 Proteasome/cyclosome repeat RPN1_C PF18051.1 PIK62397.1 - 2e-17 63.0 0.1 3.6e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 PIK62397.1 - 0.0037 17.6 0.8 0.41 11.1 0.0 3.9 3 2 1 4 4 4 1 HEAT repeats Utp13 PF08625.11 PIK62397.1 - 0.11 12.5 3.3 0.2 11.6 0.1 2.5 3 0 0 3 3 3 0 Utp13 specific WD40 associated domain V-ATPase_C PF03223.15 PIK62398.1 - 2.6e-157 524.0 4.2 3e-157 523.8 4.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C TolA_bind_tri PF16331.5 PIK62398.1 - 0.13 12.4 0.1 8.9 6.5 0.0 2.9 3 0 0 3 3 3 0 TolA binding protein trimerisation RRM_1 PF00076.22 PIK62399.1 - 5.7e-21 74.1 0.1 9.7e-21 73.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) adh_short PF00106.25 PIK62401.1 - 2.9e-30 105.2 0.4 1.3e-29 103.0 0.4 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK62401.1 - 4.7e-14 52.5 0.1 3.5e-13 49.7 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK62401.1 - 1.6e-06 28.1 0.5 3.8e-05 23.7 0.1 2.1 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 PIK62401.1 - 0.00078 19.4 0.1 0.0012 18.8 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 PIK62401.1 - 0.005 16.0 0.3 0.009 15.2 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 PIK62401.1 - 0.0081 15.6 0.0 0.035 13.6 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 PIK62401.1 - 0.013 15.7 0.1 0.03 14.6 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 PIK62401.1 - 0.054 13.4 0.1 0.096 12.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RNA_helicase PF00910.22 PIK62401.1 - 0.11 12.9 0.0 0.31 11.5 0.0 1.7 1 1 0 1 1 1 0 RNA helicase zf-C3HC4_3 PF13920.6 PIK62402.1 - 3.3e-06 26.9 10.6 3.3e-06 26.9 10.6 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 PIK62402.1 - 2.9e-05 23.9 11.0 2.9e-05 23.9 11.0 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-B_box PF00643.24 PIK62402.1 - 7.3e-05 22.8 9.9 7.3e-05 22.8 9.9 3.3 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4 PF00097.25 PIK62402.1 - 8.5e-05 22.3 14.2 8.5e-05 22.3 14.2 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK62402.1 - 0.0017 18.2 11.2 0.0017 18.2 11.2 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK62402.1 - 0.0021 18.0 6.6 0.0021 18.0 6.6 3.7 3 1 0 3 3 3 2 RING-type zinc-finger HAP1_N PF04849.13 PIK62402.1 - 0.012 14.9 0.5 0.014 14.6 0.5 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region zf-C3HC4_4 PF15227.6 PIK62402.1 - 0.025 14.7 13.8 0.025 14.7 13.8 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Tup_N PF08581.10 PIK62402.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 Tup N-terminal Zip PF02535.22 PIK62403.1 - 7.8e-76 255.4 5.6 7.8e-76 255.4 5.6 2.3 1 1 1 2 2 2 1 ZIP Zinc transporter CRA PF06589.11 PIK62403.1 - 0.012 15.7 0.6 0.24 11.5 0.9 2.4 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) DUF1772 PF08592.11 PIK62403.1 - 0.14 12.5 0.3 11 6.3 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) LSM PF01423.22 PIK62404.1 - 3.3e-17 61.9 0.1 3.9e-17 61.7 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 PIK62404.1 - 0.0027 17.8 0.1 0.0042 17.2 0.1 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain zf-DNL PF05180.12 PIK62405.1 - 1.1e-28 99.0 1.9 1.1e-28 98.9 0.1 1.8 2 0 0 2 2 2 1 DNL zinc finger Elf1 PF05129.13 PIK62405.1 - 0.021 14.8 0.1 0.048 13.7 0.1 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like APG6 PF04111.12 PIK62406.1 - 4.4e-77 258.1 3.5 7.4e-77 257.3 0.2 2.4 2 1 0 3 3 3 1 Apg6 BARA domain APG6_N PF17675.1 PIK62406.1 - 8.4e-29 100.8 31.7 8.4e-29 100.8 31.7 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region BH3 PF15285.6 PIK62406.1 - 1.5e-07 31.0 0.0 2.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting FapA PF03961.13 PIK62406.1 - 0.00058 18.6 6.5 0.00087 18.0 6.5 1.4 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF2353 PF09789.9 PIK62406.1 - 0.22 10.9 17.8 0.15 11.4 15.8 1.6 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DNA_topoisoIV PF00521.20 PIK62406.1 - 1.1 8.0 9.7 0.69 8.7 7.9 1.5 2 0 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A GIDA_assoc PF13932.6 PIK62406.1 - 2 8.5 10.4 3.7 7.7 10.4 1.4 1 0 0 1 1 1 0 GidA associated domain YabA PF06156.13 PIK62406.1 - 4.2 8.0 14.2 3.7 8.2 10.7 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Shisa PF13908.6 PIK62407.1 - 0.0035 17.6 0.1 0.0056 16.9 0.1 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Syndecan PF01034.20 PIK62407.1 - 0.0083 16.0 0.6 0.026 14.5 0.6 1.8 1 0 0 1 1 1 1 Syndecan domain PRIMA1 PF16101.5 PIK62407.1 - 0.014 15.4 0.5 0.078 13.0 0.0 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Ig_3 PF13927.6 PIK62407.1 - 0.024 15.2 2.1 1.2 9.7 0.0 3.3 2 1 1 3 3 3 0 Immunoglobulin domain ig PF00047.25 PIK62407.1 - 0.028 14.6 0.3 1.7 8.9 0.1 3.2 1 1 1 2 2 2 0 Immunoglobulin domain FAM163 PF15069.6 PIK62407.1 - 0.055 13.9 0.0 0.096 13.1 0.0 1.4 1 0 0 1 1 1 0 FAM163 family CYYR1 PF10873.8 PIK62407.1 - 0.056 13.9 2.7 0.11 13.0 2.7 1.4 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Ig_3 PF13927.6 PIK62408.1 - 1.8e-05 25.2 7.2 0.0045 17.5 0.0 4.1 3 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK62408.1 - 0.0001 22.4 3.5 0.0014 18.7 0.1 3.4 3 0 0 3 3 3 1 Immunoglobulin domain TMEM154 PF15102.6 PIK62408.1 - 0.019 14.9 0.3 0.06 13.2 0.3 1.8 1 0 0 1 1 1 0 TMEM154 protein family Shisa PF13908.6 PIK62408.1 - 0.022 15.0 0.1 0.022 15.0 0.1 1.9 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator SIT PF15330.6 PIK62408.1 - 0.025 15.0 0.2 0.074 13.5 0.0 1.9 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 PIK62408.1 - 0.067 14.1 0.0 0.27 12.1 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_3 PF13927.6 PIK62409.1 - 5.2e-05 23.8 8.1 0.04 14.5 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 PIK62409.1 - 0.0029 17.8 2.3 1.9 8.7 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 PIK62410.1 - 6e-05 23.1 2.8 0.075 13.2 0.5 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 PIK62410.1 - 0.00075 20.0 7.1 3.1 8.5 0.0 4.4 2 2 3 5 5 5 2 Immunoglobulin domain gpUL132 PF11359.8 PIK62410.1 - 0.0088 15.6 0.2 0.022 14.3 0.2 1.6 1 0 0 1 1 1 1 Glycoprotein UL132 Shisa PF13908.6 PIK62410.1 - 0.016 15.4 0.1 0.049 13.9 0.1 1.9 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SIT PF15330.6 PIK62410.1 - 0.065 13.7 0.1 0.26 11.7 0.0 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Syndecan PF01034.20 PIK62410.1 - 0.087 12.7 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain FYDLN_acid PF09538.10 PIK62410.1 - 0.85 10.3 5.5 4.8 7.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) ig PF00047.25 PIK62411.1 - 0.00016 21.7 4.3 0.014 15.5 0.2 3.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 PIK62411.1 - 0.0022 18.6 10.5 0.13 12.9 0.0 4.8 4 1 1 5 5 5 2 Immunoglobulin domain Shisa PF13908.6 PIK62411.1 - 0.017 15.3 0.2 0.054 13.7 0.0 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Syndecan PF01034.20 PIK62411.1 - 0.021 14.8 0.8 0.058 13.3 0.8 1.7 1 0 0 1 1 1 0 Syndecan domain Peptidase_S41_N PF11918.8 PIK62411.1 - 0.055 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP GspH PF12019.8 PIK62411.1 - 0.082 13.3 1.2 2 8.9 0.1 2.8 3 0 0 3 3 3 0 Type II transport protein GspH CYYR1 PF10873.8 PIK62411.1 - 0.087 13.3 2.7 0.18 12.2 2.7 1.5 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Shisa PF13908.6 PIK62412.1 - 0.015 15.6 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ig PF00047.25 PIK62412.1 - 0.016 15.4 8.3 0.12 12.6 0.1 3.9 4 0 0 4 4 4 0 Immunoglobulin domain Peptidase_S41_N PF11918.8 PIK62412.1 - 0.023 14.9 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Ig_3 PF13927.6 PIK62412.1 - 0.045 14.3 15.7 0.097 13.3 0.0 4.6 5 1 1 6 6 6 0 Immunoglobulin domain Syndecan PF01034.20 PIK62412.1 - 0.083 12.8 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 Syndecan domain SIT PF15330.6 PIK62412.1 - 0.1 13.0 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Ig_3 PF13927.6 PIK62413.1 - 0.00012 22.6 7.1 0.53 10.9 0.0 4.2 3 1 1 4 4 4 3 Immunoglobulin domain Shisa PF13908.6 PIK62413.1 - 0.0064 16.8 0.1 0.017 15.4 0.1 1.7 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF3857 PF12969.7 PIK62413.1 - 0.018 15.2 0.8 0.064 13.3 0.0 2.2 2 1 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3857) ig PF00047.25 PIK62413.1 - 0.021 15.0 2.4 1.4 9.1 0.0 3.6 3 1 1 4 4 4 0 Immunoglobulin domain DUF3481 PF11980.8 PIK62413.1 - 0.037 13.7 0.0 0.086 12.5 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein FAM163 PF15069.6 PIK62413.1 - 0.04 14.4 0.4 0.086 13.3 0.0 1.8 2 0 0 2 2 2 0 FAM163 family Syndecan PF01034.20 PIK62413.1 - 1.9 8.4 7.0 0.082 12.8 0.8 1.9 2 0 0 2 2 2 0 Syndecan domain FYDLN_acid PF09538.10 PIK62413.1 - 2.2 9.0 0.0 2.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) CUE PF02845.16 PIK62415.1 - 5.3e-05 22.8 3.6 23 4.8 0.0 6.5 7 0 0 7 7 7 0 CUE domain HTH_25 PF13413.6 PIK62415.1 - 0.00032 20.5 0.0 14 5.6 0.0 5.0 3 3 4 7 7 7 0 Helix-turn-helix domain TerB PF05099.13 PIK62415.1 - 0.0019 18.2 1.6 6 6.8 0.0 4.0 1 1 3 4 4 4 1 Tellurite resistance protein TerB SGS PF05002.15 PIK62415.1 - 0.0029 17.7 5.6 8.5 6.6 0.1 4.2 1 1 4 5 5 5 2 SGS domain Stanniocalcin PF03298.13 PIK62415.1 - 0.003 16.9 0.1 2.5 7.4 0.0 2.9 2 1 2 4 4 4 2 Stanniocalcin family DHC PF09626.10 PIK62415.1 - 0.0032 18.3 2.8 4.6 8.2 0.1 3.9 1 1 4 5 5 5 1 Dihaem cytochrome c UBA_3 PF09288.10 PIK62415.1 - 0.0052 16.6 2.5 25 4.8 0.0 5.2 4 1 3 7 7 7 0 Fungal ubiquitin-associated domain DUF262 PF03235.14 PIK62415.1 - 0.043 14.0 15.8 0.38 10.9 1.2 3.6 1 1 2 3 3 3 0 Protein of unknown function DUF262 ALF PF03752.13 PIK62415.1 - 0.051 13.6 0.4 2.1e+02 2.0 0.0 4.6 5 0 0 5 5 5 0 Short repeats of unknown function DUF2420 PF10336.9 PIK62415.1 - 0.079 13.0 17.2 1.2 9.2 0.2 5.3 2 2 3 6 6 6 0 Protein of unknown function (DUF2420) PC_rep PF01851.22 PIK62415.1 - 0.088 13.3 1.3 27 5.4 0.0 4.8 4 2 3 7 7 7 0 Proteasome/cyclosome repeat 5_3_exonuc_N PF02739.16 PIK62415.1 - 0.13 12.2 10.5 5.3 6.9 1.3 5.2 1 1 4 5 5 5 0 5'-3' exonuclease, N-terminal resolvase-like domain DHquinase_I PF01487.15 PIK62415.1 - 0.25 11.6 5.9 2.5 8.3 2.0 2.8 1 1 2 3 3 3 0 Type I 3-dehydroquinase TGFb_propeptide PF00688.18 PIK62415.1 - 0.88 9.3 11.4 4.8 6.8 4.3 3.5 1 1 2 3 3 3 0 TGF-beta propeptide NUDIX PF00293.28 PIK62416.1 - 1.7e-24 86.3 0.1 2.4e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain GH3 PF03321.13 PIK62418.1 - 1.8e-75 254.8 1.0 3.4e-59 201.1 0.1 2.0 1 1 1 2 2 2 2 GH3 auxin-responsive promoter Integrin_beta PF00362.18 PIK62419.1 - 9.9e-95 316.9 0.1 2e-94 315.9 0.1 1.4 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 PIK62419.1 - 9.9e-20 70.0 0.5 1.6e-19 69.3 0.5 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 PIK62419.1 - 1.6e-15 57.4 2.6 1.6e-15 57.4 2.6 3.9 4 0 0 4 4 4 1 Integrin beta tail domain I-EGF_1 PF18372.1 PIK62419.1 - 2e-09 37.4 9.6 2e-09 37.4 9.6 6.8 7 0 0 7 7 7 3 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 PIK62419.1 - 1.1e-05 25.7 103.2 0.00038 20.8 15.1 7.1 6 1 1 7 7 7 4 EGF-like domain TMEM154 PF15102.6 PIK62419.1 - 0.14 12.1 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family MIF4G PF02854.19 PIK62420.1 - 1.7e-14 54.0 8.8 1.7e-14 54.0 8.8 2.2 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 PIK62420.1 - 0.0097 15.9 0.4 0.036 14.1 0.1 2.1 2 0 0 2 2 2 1 MA3 domain ALS2CR8 PF15299.6 PIK62421.1 - 4.4e-33 115.0 5.8 8e-33 114.2 5.8 1.4 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 UBA2_C PF16195.5 PIK62421.1 - 0.35 11.6 3.0 8.5 7.1 0.2 2.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus 7tm_1 PF00001.21 PIK62422.1 - 2.6e-24 86.0 5.9 3.3e-24 85.6 5.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ESSS PF10183.9 PIK62422.1 - 0.074 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Nramp PF01566.18 PIK62423.1 - 6.2e-122 407.0 10.4 6.2e-122 407.0 10.4 2.0 1 1 1 2 2 2 1 Natural resistance-associated macrophage protein PCAF_N PF06466.11 PIK62424.1 - 4.5e-116 386.8 5.9 5.8e-116 386.4 5.9 1.1 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 PIK62425.1 - 2.5e-05 24.2 0.2 5.7e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Bromodomain Pkinase PF00069.25 PIK62426.1 - 2.3e-67 227.2 0.0 3.2e-67 226.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62426.1 - 1.3e-34 119.7 0.0 1.8e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK62426.1 - 3e-06 26.8 0.0 5.3e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 PIK62426.1 - 4.1e-05 22.5 1.5 7.7e-05 21.6 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 PIK62426.1 - 0.0011 18.4 0.1 0.002 17.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 PIK62426.1 - 0.02 14.5 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL 7tm_1 PF00001.21 PIK62427.1 - 2.7e-21 76.1 8.6 3.9e-21 75.6 8.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK62427.1 - 0.0035 17.0 12.5 0.0046 16.6 12.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Guanylate_cyc PF00211.20 PIK62428.1 - 1e-58 198.0 0.0 1.4e-58 197.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 PIK62428.1 - 3e-15 56.3 0.8 4.5e-15 55.7 0.8 1.2 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 PIK62428.1 - 0.0054 17.3 0.2 0.015 15.9 0.0 1.8 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1053) TBK1_ULD PF18396.1 PIK62428.1 - 0.082 12.9 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF2157 PF09925.9 PIK62429.1 - 0.056 13.2 0.7 0.82 9.4 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Ac81 PF05820.11 PIK62429.1 - 7.3 6.1 10.5 6 6.4 4.3 2.1 2 0 0 2 2 2 0 Baculoviridae AC81 Guanylate_cyc PF00211.20 PIK62430.1 - 1.7e-50 171.2 0.1 2.1e-50 170.9 0.1 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RGCC PF15151.6 PIK62430.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Response gene to complement 32 protein family PAXX PF15384.6 PIK62431.1 - 0.041 13.6 2.2 0.18 11.5 0.7 2.4 2 0 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Plasmid_RAQPRD PF09686.10 PIK62431.1 - 0.1 12.8 2.9 0.18 12.0 0.7 2.4 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) G10 PF01125.17 PIK62431.1 - 3.3 7.5 12.9 0.37 10.6 0.4 3.8 3 1 0 3 3 3 0 G10 protein Transcrip_reg PF01709.20 PIK62432.1 - 4.4e-62 209.6 0.0 5.1e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator dsrm PF00035.26 PIK62433.1 - 3e-31 107.9 0.1 4e-16 59.5 0.0 3.4 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.7 PIK62433.1 - 1.1e-12 48.0 0.5 0.00018 21.7 0.0 4.3 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.5 PIK62433.1 - 9.8e-07 28.9 0.8 3.6e-05 23.9 0.1 2.6 2 1 1 3 3 3 1 Staufen C-terminal domain LPP20 PF02169.16 PIK62433.1 - 0.002 18.4 3.5 0.0068 16.7 0.3 2.6 3 0 0 3 3 3 1 LPP20 lipoprotein SH3BP5 PF05276.14 PIK62434.1 - 3.6e-60 203.6 33.1 4.8e-60 203.2 33.1 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF4856 PF16148.5 PIK62434.1 - 0.001 18.2 5.6 0.001 18.2 5.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4856) Retrotrans_gag PF03732.17 PIK62434.1 - 1.7 9.0 8.5 0.29 11.4 3.1 2.5 1 1 2 3 3 3 0 Retrotransposon gag protein Com_YlbF PF06133.11 PIK62434.1 - 2.8 8.6 31.7 0.57 10.8 6.2 3.8 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA Usp PF00582.26 PIK62434.1 - 3.9 8.0 13.7 0.1 13.1 5.8 2.5 2 1 1 3 3 3 0 Universal stress protein family DUF2849 PF11011.8 PIK62434.1 - 5.7 7.7 6.4 0.71 10.6 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) GAS PF13851.6 PIK62434.1 - 10 5.4 36.1 0.46 9.8 10.9 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding RhoGAP PF00620.27 PIK62435.1 - 3.6e-43 147.0 0.0 7e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PDZ_6 PF17820.1 PIK62435.1 - 2.5e-15 56.0 0.3 6.4e-15 54.8 0.3 1.8 1 0 0 1 1 1 1 PDZ domain PH_9 PF15410.6 PIK62435.1 - 2.3e-11 44.1 0.0 9.7e-11 42.1 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 PIK62435.1 - 6e-11 42.8 0.8 3.3e-10 40.4 0.1 2.7 2 0 0 2 2 2 1 PH domain PDZ PF00595.24 PIK62435.1 - 1.2e-09 38.3 0.3 2.7e-09 37.3 0.3 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 PIK62435.1 - 2.3e-07 31.0 1.4 1.2e-06 28.7 0.9 2.4 2 0 0 2 2 2 1 PDZ domain Kelch_2 PF07646.15 PIK62435.1 - 0.099 12.7 0.0 5.3 7.2 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Tricorn_PDZ PF14685.6 PIK62435.1 - 0.13 12.2 0.2 0.33 11.0 0.2 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF2380 PF09533.10 PIK62435.1 - 0.46 10.1 2.8 11 5.5 0.1 2.6 2 0 0 2 2 2 0 Predicted lipoprotein of unknown function (DUF2380) ERCC3_RAD25_C PF16203.5 PIK62436.1 - 1e-108 362.2 0.3 4e-108 360.3 0.3 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 PIK62436.1 - 5.2e-38 130.0 0.0 1.7e-37 128.4 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK62436.1 - 3.3e-18 66.3 0.0 9.1e-18 64.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK62436.1 - 2.5e-09 37.5 0.1 7.4e-09 35.9 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 PIK62436.1 - 9.9e-06 24.5 0.0 1.2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 PIK62436.1 - 0.00044 20.1 0.0 0.00076 19.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase PET122 PF05476.11 PIK62436.1 - 0.0078 15.5 0.8 0.015 14.6 0.8 1.4 1 0 0 1 1 1 1 PET122 AAA_34 PF13872.6 PIK62436.1 - 0.014 14.3 0.1 0.027 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 zf-CDGSH PF09360.10 PIK62437.1 - 9.2e-20 70.6 1.2 3e-10 40.2 0.1 2.2 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type GDNF PF02351.16 PIK62437.1 - 0.021 15.8 4.3 1.2 10.2 0.1 2.1 1 1 1 2 2 2 0 GDNF/GAS1 domain Glyco_hydro_35 PF01301.19 PIK62438.1 - 3.5e-92 309.4 0.9 5.1e-54 184.0 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 PIK62438.1 - 3.3e-08 33.3 0.0 4.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 PIK62438.1 - 0.0029 18.2 1.8 0.0067 17.0 0.0 2.5 3 1 0 3 3 3 1 Beta-galactosidase jelly roll domain DUF3324 PF11797.8 PIK62438.1 - 0.077 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) PDCD2_C PF04194.13 PIK62439.1 - 4.2e-48 163.7 4.0 4.6e-46 157.1 0.6 2.6 2 1 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 PIK62439.1 - 6.1e-08 32.6 14.4 6.1e-08 32.6 14.4 2.7 3 0 0 3 3 3 1 MYND finger EF-hand_1 PF00036.32 PIK62440.1 - 4.7e-17 60.2 6.5 1.5e-06 27.3 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 PIK62440.1 - 1.4e-15 57.5 5.9 1.4e-12 47.9 1.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 PIK62440.1 - 1.6e-15 55.6 3.3 7.3e-06 25.5 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 PIK62440.1 - 3.5e-12 45.2 3.1 8.7e-06 25.0 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 PIK62440.1 - 2.4e-06 27.3 8.9 0.00059 19.6 2.8 3.0 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 PIK62440.1 - 0.0018 18.6 1.4 1.3 9.4 0.2 2.9 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 PIK62440.1 - 0.095 12.9 0.3 1.2 9.4 0.2 2.2 1 1 1 2 2 2 0 Dockerin type I domain UPF0561 PF10573.9 PIK62441.1 - 0.43 10.7 4.9 0.31 11.2 1.8 1.9 1 1 1 2 2 2 0 Uncharacterised protein family UPF0561 Amidohydro_2 PF04909.14 PIK62444.1 - 3.8e-43 148.3 0.1 4.5e-43 148.1 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase Ank_2 PF12796.7 PIK62445.1 - 0.065 13.8 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK62445.1 - 0.13 12.8 0.2 20 6.2 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeat DUF3992 PF13157.6 PIK62446.1 - 0.066 14.0 2.0 0.094 13.5 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3992) Lectin_C PF00059.21 PIK62447.1 - 8.7e-05 23.2 0.1 0.00023 21.8 0.0 1.7 2 0 0 2 2 2 1 Lectin C-type domain PNP_phzG_C PF10590.9 PIK62448.1 - 1.8e-19 69.5 0.9 3.1e-19 68.7 0.9 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Methyltransf_16 PF10294.9 PIK62449.1 - 8.2e-15 55.0 0.0 1.1e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 PIK62449.1 - 1e-07 32.0 0.0 1.3e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK62449.1 - 4.9e-07 30.4 0.0 7.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK62449.1 - 8.5e-07 28.9 0.0 1.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK62449.1 - 3.6e-05 24.4 0.0 0.00011 22.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 PIK62449.1 - 8.1e-05 23.2 0.0 0.00019 22.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 PIK62449.1 - 0.0039 16.6 0.0 0.014 14.9 0.0 1.8 1 1 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 PIK62449.1 - 0.013 15.0 0.0 0.026 14.1 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase small domain Phage_Integr_2 PF13009.6 PIK62449.1 - 0.05 12.7 0.0 0.06 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative phage integrase PrmA PF06325.13 PIK62449.1 - 0.068 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 PIK62449.1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 SAP PF02037.27 PIK62450.1 - 8.5e-14 50.9 2.3 2.3e-13 49.6 2.3 1.8 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 PIK62450.1 - 1.5e-05 24.7 18.8 0.035 13.9 0.9 4.6 4 1 0 4 4 4 3 Tho1/MOS11 C-terminal domain Packaging_FI PF14000.6 PIK62450.1 - 0.017 15.6 7.9 0.017 15.6 7.9 1.9 2 0 0 2 2 2 0 DNA packaging protein FI MMR_HSR1 PF01926.23 PIK62451.1 - 1.3e-23 83.3 0.0 2.3e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 PIK62451.1 - 3e-23 82.1 4.5 1.1e-22 80.3 4.5 1.9 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 PIK62451.1 - 1.2e-10 41.1 0.1 4.8e-09 35.9 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B MeaB PF03308.16 PIK62451.1 - 0.00016 20.8 0.1 0.32 10.0 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 PIK62451.1 - 0.00097 18.7 0.0 0.7 9.4 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 PIK62451.1 - 0.0046 16.8 0.0 0.17 11.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Arf PF00025.21 PIK62451.1 - 0.013 15.0 0.0 0.042 13.3 0.0 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family Dynamin_N PF00350.23 PIK62451.1 - 0.018 15.1 0.0 1 9.4 0.0 2.6 1 1 1 2 2 2 0 Dynamin family ABC_tran PF00005.27 PIK62451.1 - 0.036 14.6 0.0 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 ABC transporter TRP_2 PF08344.11 PIK62452.1 - 5.4e-08 32.9 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 PIK62452.1 - 0.16 12.6 0.0 0.55 10.9 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ion_trans PF00520.31 PIK62453.1 - 8.7e-18 64.4 3.4 9.8e-18 64.3 3.4 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK62453.1 - 0.011 14.4 0.2 0.011 14.4 0.2 1.4 2 0 0 2 2 2 0 Polycystin cation channel AAA PF00004.29 PIK62454.1 - 5.8e-39 133.5 0.0 1.5e-38 132.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 PIK62454.1 - 1.5e-12 47.1 0.0 4.1e-12 45.7 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 PIK62454.1 - 6.2e-07 29.3 0.4 1.6e-06 28.0 0.4 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 PIK62454.1 - 4.2e-06 26.8 0.1 2.4e-05 24.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 PIK62454.1 - 4.3e-06 27.2 0.2 3.2e-05 24.4 0.0 2.2 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 PIK62454.1 - 2.7e-05 24.0 0.0 5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 PIK62454.1 - 0.00013 22.1 0.1 0.00049 20.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 PIK62454.1 - 0.00015 22.1 0.5 0.0079 16.5 0.5 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK62454.1 - 0.00064 20.3 0.3 0.0067 17.0 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 PIK62454.1 - 0.0011 19.2 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 PIK62454.1 - 0.0021 17.3 0.0 0.0051 16.1 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 PIK62454.1 - 0.0024 17.6 0.0 0.0057 16.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 PIK62454.1 - 0.0059 16.1 0.1 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein ATPase PF06745.13 PIK62454.1 - 0.0079 15.6 0.0 0.019 14.3 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA_3 PF07726.11 PIK62454.1 - 0.0088 15.9 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 PIK62454.1 - 0.01 15.2 0.1 0.024 14.0 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 PIK62454.1 - 0.022 15.0 1.1 0.033 14.4 0.1 1.8 2 1 0 2 2 1 0 AAA domain AAA_24 PF13479.6 PIK62454.1 - 0.023 14.4 0.1 0.09 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 PIK62454.1 - 0.023 14.4 0.1 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_17 PF13207.6 PIK62454.1 - 0.032 14.7 1.2 0.62 10.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 PIK62454.1 - 0.038 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region SlyX PF04102.12 PIK62454.1 - 0.038 14.6 1.9 0.15 12.7 1.9 2.1 1 0 0 1 1 1 0 SlyX AAA_11 PF13086.6 PIK62454.1 - 0.039 13.7 0.2 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 PIK62454.1 - 0.044 13.8 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 PIK62454.1 - 0.045 14.3 0.2 0.41 11.2 0.0 2.5 2 1 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 PIK62454.1 - 0.049 13.2 0.2 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 PIK62454.1 - 0.05 13.9 0.3 0.26 11.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 PIK62454.1 - 0.055 13.9 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 PIK62454.1 - 0.057 12.5 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF815 PF05673.13 PIK62454.1 - 0.059 12.5 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 PIK62454.1 - 0.11 12.3 0.2 0.29 10.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain Spc24 PF08286.11 PIK62454.1 - 0.11 12.8 0.5 0.3 11.3 0.5 1.8 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Viral_P18 PF04521.13 PIK62454.1 - 0.12 12.1 1.0 0.19 11.5 0.3 1.7 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein RILP PF11461.8 PIK62454.1 - 0.18 12.0 7.6 1.1 9.5 7.6 2.2 1 1 0 1 1 1 0 Rab interacting lysosomal protein DUF743 PF05332.11 PIK62454.1 - 0.2 11.7 0.9 1.6 8.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF743) Zeta_toxin PF06414.12 PIK62454.1 - 0.22 10.8 0.0 0.22 10.8 0.0 2.2 3 1 0 3 3 2 0 Zeta toxin V-SNARE PF05008.15 PIK62454.1 - 0.91 9.9 5.6 1.3 9.5 4.1 2.0 2 0 0 2 2 1 0 Vesicle transport v-SNARE protein N-terminus AD PF09793.9 PIK62455.1 - 1.8e-18 66.4 0.7 3.1e-18 65.7 0.7 1.4 1 0 0 1 1 1 1 Anticodon-binding domain Gemin6 PF06372.12 PIK62455.1 - 0.0024 17.5 0.7 0.0029 17.2 0.7 1.3 1 1 0 1 1 1 1 Gemin6 protein BofC_C PF08955.10 PIK62455.1 - 0.09 12.8 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 BofC C-terminal domain Sulfotransfer_2 PF03567.14 PIK62456.1 - 3.5e-10 40.2 1.1 5.2e-10 39.7 1.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK62456.1 - 0.00023 20.8 0.2 0.0014 18.2 0.2 2.0 1 1 0 1 1 1 1 Sulfotransferase domain DUF3667 PF12412.8 PIK62456.1 - 0.068 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) Sulfotransfer_2 PF03567.14 PIK62457.1 - 0.00011 22.2 0.3 0.00024 21.1 0.0 1.6 1 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 PIK62457.1 - 0.016 14.7 0.0 0.085 12.3 0.0 1.9 1 1 0 1 1 1 0 Sulfotransferase domain 7tm_2 PF00002.24 PIK62458.1 - 1.3e-11 44.3 0.1 1.6e-11 44.0 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Arm_vescicular PF18770.1 PIK62458.1 - 0.068 13.1 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor CUB PF00431.20 PIK62459.1 - 3.1e-20 72.6 0.0 4.8e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 CUB domain Ldl_recept_b PF00058.17 PIK62459.1 - 1.8e-08 34.7 0.1 0.01 16.3 0.1 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor repeat class B SGL PF08450.12 PIK62459.1 - 0.038 13.6 0.1 0.24 10.9 0.0 1.9 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region ECH_1 PF00378.20 PIK62460.1 - 1.3e-38 132.8 0.0 1.6e-38 132.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase PolyA_pol_arg_C PF12626.7 PIK62460.1 - 0.1 12.6 0.5 1.3 9.1 0.1 2.1 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus RVT_1 PF00078.27 PIK62461.1 - 8.9e-23 81.0 0.0 1.4e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK62462.1 - 2.2e-21 75.7 1.9 2.5e-21 75.5 0.5 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK62462.1 - 1.4e-18 67.2 0.0 2.5e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 PIK62462.1 - 2.6e-08 34.0 0.1 7.2e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 H2C2 zinc finger AphA_like PF14557.6 PIK62462.1 - 0.092 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator ECH_1 PF00378.20 PIK62463.1 - 1.5e-26 93.2 0.1 1.2e-19 70.6 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK62463.1 - 0.11 12.0 0.2 6.8 6.1 0.0 2.1 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Exo_endo_phos_2 PF14529.6 PIK62464.1 - 3.2e-12 46.3 0.4 3.6e-11 42.9 0.1 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK62464.1 - 1.1e-07 31.7 0.1 2.3e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ISN1 PF06437.11 PIK62465.1 - 0.023 13.6 0.6 0.033 13.1 0.6 1.2 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase EF-hand_4 PF12763.7 PIK62465.1 - 0.079 12.9 1.4 0.2 11.6 1.4 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Mod_r PF07200.13 PIK62465.1 - 0.082 13.0 8.4 3.7 7.6 0.1 2.6 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Tmemb_cc2 PF10267.9 PIK62465.1 - 0.24 10.5 7.9 0.03 13.5 2.7 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Atg14 PF10186.9 PIK62465.1 - 7.5 5.5 12.4 7.7 5.5 0.1 2.6 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Kinesin PF00225.23 PIK62466.1 - 1.6e-85 287.0 0.4 1.6e-85 287.0 0.4 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 PIK62466.1 - 3.9e-15 56.1 0.0 9.2e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 PIK62466.1 - 0.00013 22.4 0.0 0.56 10.6 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain PKcGMP_CC PF16808.5 PIK62466.1 - 0.044 13.6 3.3 6.1 6.8 1.0 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4404 PF14357.6 PIK62466.1 - 1.1 10.0 6.7 0.15 12.7 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) COG5 PF10392.9 PIK62466.1 - 1.3 9.2 7.6 0.15 12.3 0.6 2.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Ku_C PF03730.14 PIK62466.1 - 3.9 8.2 6.1 4.5 8.0 0.3 3.1 2 1 1 3 3 3 0 Ku70/Ku80 C-terminal arm FH2 PF02181.23 PIK62467.1 - 4e-87 292.7 7.3 4e-87 292.7 7.3 2.9 2 1 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 PIK62467.1 - 1.3e-49 168.4 0.9 1.3e-49 168.4 0.9 2.1 1 1 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 PIK62467.1 - 6.3e-30 104.1 0.0 6.3e-30 104.1 0.0 3.3 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain Mito_fiss_reg PF05308.11 PIK62467.1 - 9.5e-05 22.6 2.8 9.5e-05 22.6 2.8 2.4 2 0 0 2 2 2 1 Mitochondrial fission regulator HTH_48 PF17906.1 PIK62467.1 - 0.077 13.1 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 HTH domain in Mos1 transposase V_ATPase_I PF01496.19 PIK62467.1 - 1.1 7.0 6.1 1.9 6.3 3.8 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CREPT PF16566.5 PIK62467.1 - 1.9 8.7 9.8 2 8.6 6.1 2.8 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2052 PF09747.9 PIK62468.1 - 2.9e-29 102.6 11.2 2.9e-29 102.6 11.2 1.7 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) Rhabdo_ncap PF00945.18 PIK62468.1 - 0.023 13.6 0.7 0.045 12.6 0.7 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein CENP-B_dimeris PF09026.10 PIK62468.1 - 0.26 11.7 13.9 0.082 13.3 6.4 2.9 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Presenilin PF01080.17 PIK62468.1 - 0.65 8.7 3.4 1 8.0 3.4 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_C97 PF05903.14 PIK62469.1 - 4.9e-40 136.8 0.0 5.8e-40 136.6 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 PIK62469.1 - 0.11 12.7 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase MAJIN PF15077.6 PIK62470.1 - 0.0044 16.9 3.4 0.0062 16.4 0.0 2.5 2 1 0 2 2 2 1 Membrane-anchored junction protein DHOR PF06537.11 PIK62470.1 - 0.13 10.8 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Di-haem oxidoreductase, putative peroxidase DTHCT PF08070.11 PIK62470.1 - 2.7 8.8 7.2 0.63 10.8 1.4 2.5 2 0 0 2 2 2 0 DTHCT (NUC029) region HAP1_N PF04849.13 PIK62471.1 - 0.041 13.1 2.9 0.085 12.0 2.9 1.4 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Cortexin PF11057.8 PIK62471.1 - 0.043 13.7 0.2 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 Cortexin of kidney Med22 PF06179.12 PIK62471.1 - 0.095 12.9 1.0 0.68 10.2 0.0 2.6 3 0 0 3 3 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex Med9 PF07544.13 PIK62471.1 - 0.12 12.5 1.0 0.78 9.9 0.8 2.5 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Sec34 PF04136.15 PIK62471.1 - 0.24 11.3 2.8 2.2 8.2 1.4 2.4 2 0 0 2 2 2 0 Sec34-like family TSNAXIP1_N PF15739.5 PIK62471.1 - 0.59 10.5 6.1 0.17 12.3 2.5 1.9 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus RVT_1 PF00078.27 PIK62472.1 - 1.6e-13 50.7 0.3 4.6e-13 49.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK62472.1 - 4.3e-06 26.6 0.1 1e-05 25.4 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62472.1 - 0.0012 18.4 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mt_ATP-synt_B PF05405.14 PIK62472.1 - 0.18 11.4 1.9 0.35 10.5 1.9 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) zf-CCHC PF00098.23 PIK62473.1 - 6.9e-07 29.1 16.8 2.1e-05 24.4 1.6 3.3 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.6 PIK62473.1 - 0.0011 18.8 6.7 0.1 12.5 0.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK62473.1 - 0.042 13.8 15.6 0.69 9.9 3.0 3.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 PIK62473.1 - 0.15 11.8 15.4 0.24 11.2 0.5 3.4 1 1 2 3 3 3 0 Zinc knuckle RVT_1 PF00078.27 PIK62474.1 - 8.2e-38 130.1 0.4 2.1e-37 128.8 0.4 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK62474.1 - 2.4e-06 27.4 0.1 6.4e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62474.1 - 7.1e-05 22.4 0.0 0.00016 21.3 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mt_ATP-synt_B PF05405.14 PIK62474.1 - 0.1 12.2 1.9 0.24 11.0 1.9 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ribosomal_L28e PF01778.17 PIK62475.1 - 0.0047 17.7 1.5 0.0072 17.1 0.3 1.9 2 0 0 2 2 2 1 Ribosomal L28e protein family p450 PF00067.22 PIK62476.1 - 5.3e-62 210.1 1.1 2.9e-61 207.6 1.1 1.8 1 1 0 1 1 1 1 Cytochrome P450 Acyltransferase PF01553.21 PIK62477.1 - 6.7e-18 64.6 0.0 1.6e-17 63.3 0.0 1.6 2 0 0 2 2 2 1 Acyltransferase TSNAXIP1_N PF15739.5 PIK62478.1 - 0.023 15.1 1.3 0.023 15.1 1.3 2.2 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF4328 PF14219.6 PIK62478.1 - 0.082 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) DUF4829 PF16111.5 PIK62478.1 - 0.46 11.3 2.3 10 6.9 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4829) C2-set_2 PF08205.12 PIK62479.1 - 0.00055 19.9 6.9 0.077 13.1 0.0 4.2 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Invasin_D3 PF09134.10 PIK62479.1 - 0.0013 19.0 2.4 1.5 9.2 0.0 4.4 4 1 0 4 4 4 1 Invasin, domain 3 Marek_A PF02124.15 PIK62479.1 - 0.028 14.3 3.4 0.51 10.1 0.0 3.1 3 0 0 3 3 3 0 Marek's disease glycoprotein A SBF_like PF13593.6 PIK62479.1 - 0.12 11.6 2.8 2.5 7.3 0.1 2.5 3 0 0 3 3 3 0 SBF-like CPA transporter family (DUF4137) DUF973 PF06157.11 PIK62479.1 - 0.25 10.4 1.4 34 3.4 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF973) RT_RNaseH_2 PF17919.1 PIK62480.1 - 5.9e-31 106.5 0.0 1e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62480.1 - 2.3e-26 92.1 0.0 3.7e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK62480.1 - 2.4e-14 53.1 0.2 5.4e-14 52.1 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK62480.1 - 7.5e-06 25.6 0.0 1.8e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 PIK62480.1 - 0.067 13.4 0.5 0.2 11.9 0.1 2.1 2 0 0 2 2 2 0 H2C2 zinc finger RVT_3 PF13456.6 PIK62480.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like gag-asp_proteas PF13975.6 PIK62481.1 - 0.0004 20.9 0.0 0.0011 19.4 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 PIK62481.1 - 0.0092 16.6 0.0 0.021 15.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Methyltransf_11 PF08241.12 PIK62482.1 - 1.2e-22 80.4 0.0 3.8e-22 78.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 PIK62482.1 - 4.5e-19 69.0 0.0 7.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 PIK62482.1 - 5.4e-13 49.0 0.0 8.1e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 PIK62482.1 - 4.1e-10 40.3 0.0 7.9e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 PIK62482.1 - 3.5e-08 33.5 0.0 6.1e-08 32.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 PIK62482.1 - 2.4e-07 30.4 0.0 4.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 PIK62482.1 - 7.9e-06 25.9 0.0 2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.12 PIK62482.1 - 0.0013 17.9 0.0 0.0018 17.5 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase TPMT PF05724.11 PIK62482.1 - 0.0019 17.9 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 PIK62482.1 - 0.01 15.4 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.12 PIK62482.1 - 0.033 14.0 0.0 0.29 10.9 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 PIK62482.1 - 0.063 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 PIK62482.1 - 0.069 12.6 0.0 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_32 PF13679.6 PIK62482.1 - 0.07 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 PIK62482.1 - 0.092 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.11 PIK62482.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase NumbF PF06311.12 PIK62483.1 - 3.9e-26 91.4 3.4 5.2e-26 91.0 0.2 2.7 3 0 0 3 3 3 1 NUMB domain PID PF00640.23 PIK62483.1 - 7.3e-24 84.4 0.0 1.6e-23 83.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 PIK62483.1 - 0.001 19.0 0.0 0.001 19.0 0.0 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) Sacchrp_dh_NADP PF03435.18 PIK62485.1 - 9.4e-13 48.6 0.0 1.4e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain SWIM PF04434.17 PIK62486.1 - 0.014 15.0 0.8 0.028 14.1 0.8 1.5 1 0 0 1 1 1 0 SWIM zinc finger UTP15_C PF09384.10 PIK62486.1 - 0.031 14.0 0.9 0.061 13.0 0.9 1.5 1 0 0 1 1 1 0 UTP15 C terminal MEF2_binding PF09047.10 PIK62486.1 - 0.18 11.7 2.3 1.9 8.4 0.1 2.7 2 0 0 2 2 2 0 MEF2 binding NYD-SP28_assoc PF14775.6 PIK62486.1 - 0.36 11.0 2.9 1 9.5 0.1 2.6 2 0 0 2 2 2 0 Sperm tail C-terminal domain Pkinase PF00069.25 PIK62487.1 - 2.4e-78 263.2 0.0 2.8e-78 262.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62487.1 - 3.4e-35 121.6 0.0 9.7e-34 116.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 PIK62487.1 - 2.3e-05 23.5 0.2 8.3e-05 21.7 0.2 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 PIK62487.1 - 0.0062 15.6 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 PIK62487.1 - 0.0091 15.3 0.0 0.028 13.7 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 PIK62487.1 - 0.023 14.6 0.0 0.056 13.4 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 PIK62487.1 - 0.054 12.8 0.7 0.15 11.4 0.7 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 PIK62487.1 - 0.097 12.2 0.4 0.23 11.0 0.2 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Peptidase_M8 PF01457.16 PIK62488.1 - 4.1e-40 138.0 4.2 2e-33 115.9 0.1 2.6 2 1 1 3 3 3 2 Leishmanolysin Colipase_C PF02740.14 PIK62488.1 - 0.051 13.8 0.4 0.49 10.6 0.1 2.5 2 0 0 2 2 2 0 Colipase, C-terminal domain Erg28 PF03694.13 PIK62489.1 - 1.1e-34 119.1 3.9 1.6e-34 118.6 3.9 1.3 1 0 0 1 1 1 1 Erg28 like protein Peptidase_M14 PF00246.24 PIK62490.1 - 2.9e-57 194.7 0.1 6.1e-57 193.6 0.1 1.5 1 1 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK62490.1 - 1.6e-09 38.0 0.1 5.9e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 Carboxypeptidase activation peptide Peptidase_M14 PF00246.24 PIK62491.1 - 8.6e-45 153.7 0.0 1.3e-44 153.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 PIK62491.1 - 1.9e-18 66.6 0.0 3.2e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase activation peptide RGS PF00615.19 PIK62492.1 - 4.4e-32 110.8 4.9 2.6e-10 40.6 2.4 5.0 4 1 0 4 4 4 4 Regulator of G protein signaling domain Nop14 PF04147.12 PIK62492.1 - 1.7 6.8 39.7 1.4 7.0 8.4 2.1 2 0 0 2 2 2 0 Nop14-like family FAM220 PF15487.6 PIK62493.1 - 0.1 12.2 1.8 0.14 11.7 1.8 1.3 1 0 0 1 1 1 0 FAM220 family DUF4286 PF14114.6 PIK62493.1 - 0.12 12.9 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) UTP25 PF06862.12 PIK62494.1 - 2.3e-171 570.8 4.3 3.1e-171 570.3 4.3 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF1081 PF06448.11 PIK62494.1 - 0.028 14.8 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1081) FAM150 PF15129.6 PIK62494.1 - 0.062 13.5 0.4 0.062 13.5 0.4 2.4 2 0 0 2 2 2 0 FAM150 family Metallophos PF00149.28 PIK62495.1 - 1.6e-09 38.5 1.2 3.2e-09 37.6 1.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase HYR PF02494.16 PIK62495.1 - 0.19 12.1 0.0 0.46 10.8 0.0 1.6 1 0 0 1 1 1 0 HYR domain FAM177 PF14774.6 PIK62496.1 - 1.7e-36 125.1 0.7 2.4e-36 124.6 0.2 1.4 1 1 0 1 1 1 1 FAM177 family His_Phos_1 PF00300.22 PIK62497.1 - 1.7e-30 106.2 0.0 2e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TetR_C_13 PF16925.5 PIK62497.1 - 0.032 14.2 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Acetyltransf_1 PF00583.25 PIK62498.1 - 1.2e-07 32.0 0.0 1.8e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 PIK62498.1 - 0.00099 19.0 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 PIK62498.1 - 0.0027 17.6 0.0 0.0047 16.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PI3Ka PF00613.20 PIK62498.1 - 0.015 14.7 0.1 0.03 13.7 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Acetyltransf_7 PF13508.7 PIK62498.1 - 0.054 13.9 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_17 PF17668.1 PIK62498.1 - 0.15 12.8 0.1 0.26 12.1 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RVT_1 PF00078.27 PIK62499.1 - 8.4e-36 123.6 1.0 3.3e-35 121.6 0.3 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 PIK62499.1 - 2.8e-10 40.0 2.4 4.8e-10 39.3 0.9 2.2 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 PIK62499.1 - 1.2e-05 25.0 0.2 2e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Oxidored_q5_N PF01059.17 PIK62499.1 - 0.052 13.6 0.3 0.13 12.4 0.3 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus Transposase_21 PF02992.14 PIK62500.1 - 2.8e-09 36.5 0.8 8.8e-09 34.9 0.0 2.1 3 0 0 3 3 3 1 Transposase family tnp2 DUF4218 PF13960.6 PIK62500.1 - 0.011 15.3 0.1 0.035 13.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4218) Ig_3 PF13927.6 PIK62501.1 - 2.9e-05 24.6 0.4 0.67 10.6 0.3 3.2 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 PIK62501.1 - 7.4e-05 22.9 0.3 0.0026 17.9 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 PIK62501.1 - 0.0023 18.1 0.1 1.8 8.8 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 PIK62501.1 - 0.017 15.2 0.1 0.5 10.5 0.0 2.6 1 1 0 2 2 2 0 Immunoglobulin I-set domain RVT_1 PF00078.27 PIK62502.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UreE_N PF02814.15 PIK62502.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 UreE urease accessory protein, N-terminal domain rve PF00665.26 PIK62503.1 - 4.6e-11 43.0 0.0 7.7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK62503.1 - 0.0058 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Pkinase_Tyr PF07714.17 PIK62504.1 - 1.9e-30 106.0 0.0 2.3e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62504.1 - 1.2e-10 41.2 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62505.1 - 2e-27 96.1 0.0 2.5e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62505.1 - 5.8e-14 52.1 0.0 9e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain KN17_SH3 PF18131.1 PIK62505.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 KN17 SH3-like C-terminal domain C2 PF00168.30 PIK62506.1 - 8.7e-19 67.7 0.0 2.4e-18 66.3 0.0 1.6 2 0 0 2 2 2 1 C2 domain FerI PF08151.12 PIK62506.1 - 4.6e-18 65.1 2.2 8.5e-18 64.2 2.2 1.5 1 0 0 1 1 1 1 FerI (NUC094) domain C2 PF00168.30 PIK62507.1 - 4e-26 91.3 0.0 9.4e-19 67.6 0.0 2.3 2 0 0 2 2 2 2 C2 domain Ferlin_C PF16165.5 PIK62507.1 - 5.3e-14 52.5 4.2 1.8e-08 34.5 0.2 2.3 1 1 1 2 2 2 2 Ferlin C-terminus B9-C2 PF07162.11 PIK62507.1 - 0.0078 16.4 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 2 Ciliary basal body-associated, B9 protein DUF2154 PF09922.9 PIK62507.1 - 0.1 12.5 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 Cell wall-active antibiotics response 4TMS YvqF XendoU PF09412.10 PIK62508.1 - 7.7e-52 176.1 1.5 1e-51 175.7 1.5 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK62508.1 - 5.5e-12 45.9 47.8 1.4e-06 28.6 13.4 3.5 2 1 1 3 3 3 2 Somatomedin B domain Metallothio_6 PF05522.11 PIK62508.1 - 5.7 7.5 36.0 14 6.3 21.4 2.5 1 1 1 2 2 2 0 Metallothionein DUF45 PF01863.17 PIK62509.1 - 0.046 13.8 0.1 0.094 12.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 FLYWCH_u PF16662.5 PIK62509.1 - 0.14 12.3 0.3 14 5.8 0.1 2.5 2 0 0 2 2 2 0 FLYWCH-type zinc finger-containing protein 1 WSC PF01822.19 PIK62511.1 - 2.2e-05 24.6 4.0 4.8e-05 23.5 4.0 1.6 1 0 0 1 1 1 1 WSC domain Sushi PF00084.20 PIK62511.1 - 0.13 12.9 0.2 0.13 12.9 0.2 2.4 2 1 0 2 2 2 0 Sushi repeat (SCR repeat) Pkinase PF00069.25 PIK62512.1 - 1.7e-72 244.0 0.1 4e-72 242.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62512.1 - 1.5e-41 142.4 0.0 2.2e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK62512.1 - 1.2e-09 37.9 0.0 3e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 PIK62512.1 - 7.8e-06 25.4 0.4 2e-05 24.1 0.4 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 PIK62512.1 - 0.00067 19.7 0.1 0.0037 17.2 0.2 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family M-inducer_phosp PF06617.13 PIK62512.1 - 0.0049 16.2 1.4 0.0095 15.3 1.4 1.4 1 0 0 1 1 1 1 M-phase inducer phosphatase RIO1 PF01163.22 PIK62512.1 - 0.0075 15.9 0.1 0.019 14.5 0.1 1.7 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 PIK62512.1 - 0.023 14.3 0.0 0.063 12.9 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 PIK62512.1 - 0.096 11.6 0.4 0.18 10.7 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Phage_int_SAM_1 PF02899.17 PIK62513.1 - 4.3e-05 23.7 1.0 0.00013 22.2 0.1 2.0 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 PIK62513.1 - 0.0002 21.8 0.0 0.00034 21.0 0.0 1.3 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Uso1_p115_head PF04869.14 PIK62515.1 - 1.2e-62 211.8 0.8 3.4e-62 210.4 0.1 2.1 2 1 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Arm_vescicular PF18770.1 PIK62515.1 - 1e-29 102.2 7.3 1.6e-29 101.6 6.0 2.1 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor Uso1_p115_C PF04871.13 PIK62515.1 - 1.3e-10 41.7 42.9 1.3e-10 41.7 42.9 4.1 2 1 2 4 4 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 PF09787.9 PIK62515.1 - 3.6 7.0 47.4 0.16 11.4 21.8 3.0 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF4201 PF13870.6 PIK62515.1 - 5.1 6.8 43.0 2.5 7.8 21.3 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) JIP_LZII PF16471.5 PIK62515.1 - 9.2 6.5 36.0 8 6.7 7.2 5.3 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II Exo_endo_phos_2 PF14529.6 PIK62516.1 - 0.003 17.4 0.1 0.67 9.8 0.0 2.9 2 1 1 3 3 3 2 Endonuclease-reverse transcriptase RVT_1 PF00078.27 PIK62517.1 - 3.4e-22 79.1 0.0 4.9e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 PIK62518.1 - 0.098 13.0 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 PRANC domain SET PF00856.28 PIK62520.1 - 6.7e-12 46.1 0.0 6.7e-12 46.1 0.0 3.3 2 2 0 2 2 2 1 SET domain Acyl-CoA_dh_1 PF00441.24 PIK62521.1 - 1.5e-23 83.7 0.2 1.8e-23 83.4 0.2 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK62521.1 - 2.6e-05 24.5 0.1 3.1e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 PIK62522.1 - 3.5e-35 121.1 0.0 6e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 PIK62522.1 - 5.5e-25 87.4 0.1 1.1e-24 86.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain SelP_N PF04592.14 PIK62523.1 - 0.044 13.2 6.9 0.045 13.1 6.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1264 PF06884.11 PIK62524.1 - 0.066 12.8 0.1 0.083 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1264) SUKH-4 PF14435.6 PIK62524.1 - 0.074 13.1 0.5 0.094 12.8 0.4 1.3 1 1 0 1 1 1 0 SUKH-4 immunity protein Ank_4 PF13637.6 PIK62525.1 - 2.8e-12 46.9 0.2 0.0015 19.1 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK62525.1 - 2.9e-12 47.0 3.0 1.8e-06 28.4 1.1 2.0 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK62525.1 - 7.3e-09 35.2 0.3 0.0064 16.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK62525.1 - 8.2e-09 35.6 1.9 0.0015 18.8 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 PIK62525.1 - 6.6e-07 29.5 1.9 0.048 14.1 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 PIK62525.1 - 0.0027 18.0 0.1 0.0034 17.6 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Ank_2 PF12796.7 PIK62526.1 - 3e-11 43.8 0.1 8.4e-11 42.3 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 PIK62526.1 - 8.3e-08 31.9 0.1 0.01 16.3 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 PIK62526.1 - 1e-07 32.4 0.3 5.5e-07 30.0 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 PIK62526.1 - 1.2e-07 31.8 0.1 0.0054 17.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 PIK62526.1 - 3.7e-06 27.1 0.0 1.7e-05 25.0 0.0 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ion_trans PF00520.31 PIK62526.1 - 0.00012 21.4 18.6 0.00025 20.4 18.6 1.6 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 PIK62526.1 - 1.5 7.4 12.9 2.8 6.5 12.9 1.5 1 0 0 1 1 1 0 Polycystin cation channel XendoU PF09412.10 PIK62527.1 - 1.5e-68 230.9 2.3 2.2e-68 230.3 2.3 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 PIK62527.1 - 8.3e-28 96.5 92.9 9e-09 35.6 15.7 4.5 4 0 0 4 4 4 4 Somatomedin B domain EndoU_bacteria PF14436.6 PIK62527.1 - 0.0017 18.7 0.0 0.0037 17.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial EndoU nuclease CC2D2AN-C2 PF15625.6 PIK62528.1 - 1.8e-58 197.1 0.1 5.2e-58 195.6 0.1 1.8 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain DUF5523 PF17661.1 PIK62528.1 - 3e-48 164.7 4.1 3e-48 164.7 4.1 3.4 3 1 0 3 3 3 1 Family of unknown function (DUF5523) C2 PF00168.30 PIK62528.1 - 0.00028 21.1 0.1 0.022 15.0 0.0 2.9 2 0 0 2 2 2 1 C2 domain Fibrinogen_C PF00147.18 PIK62529.1 - 1.8e-68 230.7 9.0 1.8e-68 230.7 9.0 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK62529.1 - 5.1e-06 26.6 7.3 5.1e-06 26.6 7.3 5.0 5 1 0 5 5 5 2 EGF domain TILa PF12714.7 PIK62529.1 - 0.019 14.9 8.9 0.019 14.9 8.9 2.9 2 1 1 3 3 3 0 TILa domain EGF_MSP1_1 PF12946.7 PIK62529.1 - 0.037 14.1 6.0 0.037 14.1 6.0 3.5 2 1 1 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK62530.1 - 5.5e-69 232.3 8.6 8.7e-69 231.7 8.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK62530.1 - 4.8e-06 26.7 6.8 4.8e-06 26.7 6.8 4.2 4 0 0 4 4 4 2 EGF domain TILa PF12714.7 PIK62530.1 - 0.0007 19.5 2.8 0.0007 19.5 2.8 2.4 2 0 0 2 2 2 1 TILa domain EGF_MSP1_1 PF12946.7 PIK62530.1 - 0.034 14.2 5.9 0.034 14.2 5.9 2.8 1 1 1 2 2 2 0 MSP1 EGF domain 1 CBFD_NFYB_HMF PF00808.23 PIK62531.1 - 3.7e-21 75.2 1.2 1.1e-20 73.7 0.9 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK62531.1 - 6.7e-18 65.3 1.1 1.5e-17 64.2 1.1 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Baseplate PF16774.5 PIK62531.1 - 0.067 13.1 2.5 0.14 12.1 2.5 1.5 1 0 0 1 1 1 0 Baseplate protein SulA PF03846.14 PIK62531.1 - 0.44 10.5 0.1 0.44 10.5 0.1 3.2 3 1 1 4 4 4 0 Cell division inhibitor SulA FERM_N PF09379.10 PIK62532.1 - 1.8e-16 59.8 0.1 2.6e-16 59.3 0.1 1.2 1 0 0 1 1 1 1 FERM N-terminal domain PH_14 PF17787.1 PIK62532.1 - 0.025 14.4 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 PH domain Dsl1_C PF11989.8 PIK62533.1 - 0.16 11.7 2.1 0.14 11.8 0.3 1.7 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 C terminal AAT PF03417.16 PIK62534.1 - 0.00082 19.1 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_C69 PF03577.15 PIK62534.1 - 0.0012 17.9 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 zf-CCHC_6 PF15288.6 PIK62536.1 - 0.0083 16.0 0.6 0.02 14.7 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle Band_3_cyto PF07565.13 PIK62536.1 - 1.7 8.4 10.7 2.5 7.8 10.7 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Macoilin PF09726.9 PIK62536.1 - 2.1 6.8 17.6 2.6 6.5 17.6 1.1 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 PIK62536.1 - 4.4 5.5 22.7 5.4 5.2 22.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4541 PF15074.6 PIK62537.1 - 2.2e-27 95.5 0.1 2.8e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4541) CoaE PF01121.20 PIK62538.1 - 8e-46 155.9 0.0 1.7e-45 154.9 0.0 1.5 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_like PF01467.26 PIK62538.1 - 7.4e-07 29.5 0.2 4.2e-06 27.0 0.2 2.3 2 1 0 2 2 2 1 Cytidylyltransferase-like AAA_33 PF13671.6 PIK62538.1 - 0.00025 21.2 0.0 0.00062 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 PIK62538.1 - 0.00071 20.1 0.2 0.0026 18.3 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 PIK62538.1 - 0.0069 16.6 0.1 0.022 15.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 PIK62538.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase FAD_syn PF06574.12 PIK62538.1 - 0.58 10.0 2.3 1 9.2 1.0 2.0 1 1 1 2 2 2 0 FAD synthetase Ank_2 PF12796.7 PIK62539.1 - 3.7e-153 498.5 52.5 3e-17 63.0 0.6 13.9 2 2 12 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 PIK62539.1 - 7.1e-126 409.1 52.4 6e-14 52.2 0.1 21.8 6 6 20 26 26 26 25 Ankyrin repeats (many copies) Ank PF00023.30 PIK62539.1 - 1.9e-119 385.3 85.9 1.4e-07 31.6 0.1 28.3 28 0 0 28 28 28 26 Ankyrin repeat Ank_5 PF13857.6 PIK62539.1 - 3.3e-105 342.8 61.5 4.7e-09 36.3 0.3 23.1 4 4 18 25 25 25 24 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK62539.1 - 1.4e-101 320.0 58.0 8.9e-05 22.6 0.0 28.5 29 0 0 29 29 29 26 Ankyrin repeat Prok-RING_1 PF14446.6 PIK62539.1 - 3.5 7.6 7.4 11 6.0 0.0 4.1 5 0 0 5 5 5 0 Prokaryotic RING finger family 1 Methyltr_RsmB-F PF01189.17 PIK62540.1 - 2.3e-41 141.6 0.0 3.8e-41 140.9 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 PIK62540.1 - 0.00024 21.3 0.0 0.0006 20.0 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase PUA PF01472.20 PIK62540.1 - 0.0044 16.9 0.0 0.012 15.6 0.0 1.8 1 0 0 1 1 1 1 PUA domain Methyltransf_31 PF13847.6 PIK62540.1 - 0.0083 15.9 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 PIK62540.1 - 0.014 15.2 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 PIK62540.1 - 0.022 14.3 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Fibrillarin PF01269.17 PIK62540.1 - 0.035 13.2 0.0 0.063 12.4 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin DUF2431 PF10354.9 PIK62540.1 - 0.055 13.7 0.0 0.99 9.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2431) Methyltransf_25 PF13649.6 PIK62540.1 - 0.098 13.4 0.1 0.66 10.7 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain Ipi1_N PF12333.8 PIK62541.1 - 6.2e-20 71.7 2.0 7.3e-19 68.3 0.1 3.7 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.7 PIK62541.1 - 0.00036 21.1 3.7 0.00061 20.3 0.1 3.3 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK62541.1 - 0.0046 17.0 1.2 0.0046 17.0 1.2 3.0 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DEAD PF00270.29 PIK62542.1 - 4.5e-43 147.1 0.0 8e-43 146.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK62542.1 - 1.1e-24 86.8 0.0 2.3e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.6 PIK62542.1 - 0.047 13.0 0.0 0.047 13.0 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF1459 PF07312.11 PIK62542.1 - 0.33 11.2 1.6 0.62 10.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1459) Trypsin PF00089.26 PIK62543.1 - 1.8e-73 247.0 2.5 2e-73 246.8 2.5 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 PIK62543.1 - 4e-05 24.0 0.0 6.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 PIK62543.1 - 8.2e-05 23.5 0.1 0.0002 22.3 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Nucleotid_trans PF03407.16 PIK62544.1 - 1.2e-35 123.5 0.0 1.6e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase COLFI PF01410.18 PIK62545.1 - 6.6e-76 254.7 0.1 8.4e-76 254.3 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Collagen PF01391.18 PIK62545.1 - 2.3e-69 229.0 271.4 1.7e-07 30.9 29.6 9.0 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 PIK62546.1 - 3.2e-09 36.4 23.8 3.2e-09 36.4 23.8 3.8 5 0 0 5 5 5 2 Collagen triple helix repeat (20 copies) Laminin_G_2 PF02210.24 PIK62546.1 - 0.00018 22.1 0.0 0.00033 21.2 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Leu_leader PF08054.11 PIK62546.1 - 0.066 12.8 0.3 0.13 11.9 0.3 1.4 1 0 0 1 1 1 0 Leucine operon leader peptide Collagen PF01391.18 PIK62547.1 - 0.0043 16.8 54.6 0.016 15.0 28.4 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Exo_endo_phos_2 PF14529.6 PIK62549.1 - 1.2e-06 28.3 0.7 3.9e-06 26.7 0.1 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Nop14 PF04147.12 PIK62549.1 - 2.2 6.4 46.4 3.6 5.7 46.4 1.2 1 0 0 1 1 1 0 Nop14-like family SpoIIIAH PF12685.7 PIK62549.1 - 3 7.6 7.1 4.8 6.9 7.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein 4HBT_2 PF13279.6 PIK62550.1 - 0.15 12.6 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily Pkinase PF00069.25 PIK62551.1 - 4e-20 72.3 0.8 4.4e-20 72.2 0.8 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62551.1 - 1.8e-10 40.6 1.0 2.2e-10 40.3 1.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Staphylokinase PF02821.16 PIK62551.1 - 0.077 13.4 0.1 0.1 13.1 0.1 1.1 1 0 0 1 1 1 0 Staphylokinase/Streptokinase family Pkinase PF00069.25 PIK62552.1 - 1.4e-22 80.3 1.4 1.4e-22 80.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62552.1 - 9.3e-11 41.5 0.4 7.5e-10 38.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4358 PF14270.6 PIK62552.1 - 0.0059 16.9 1.1 0.0059 16.9 1.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4358) CENP-H PF05837.12 PIK62552.1 - 0.21 12.0 3.8 0.36 11.3 3.8 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4764 PF15961.5 PIK62553.1 - 0.00092 18.0 0.2 0.54 8.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4764) PBP1_TM PF14812.6 PIK62553.1 - 0.0039 17.5 0.7 0.0079 16.5 0.7 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal HSP70 PF00012.20 PIK62554.1 - 1.8e-157 525.2 30.6 8e-55 186.1 0.5 4.1 3 1 1 4 4 4 4 Hsp70 protein MreB_Mbl PF06723.13 PIK62554.1 - 1.7e-08 33.7 0.1 3.8e-07 29.3 0.0 2.3 1 1 1 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 PIK62554.1 - 9.2e-05 22.2 0.1 0.00019 21.2 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 PIK62554.1 - 0.0007 20.0 1.1 0.0092 16.4 0.0 2.6 2 0 0 2 2 2 1 Cell division protein FtsA DUF1464 PF07318.12 PIK62554.1 - 0.027 13.6 0.0 0.062 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) CdhD PF03599.16 PIK62554.1 - 0.066 11.9 0.5 0.22 10.2 0.0 1.9 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Ala_racemase_N PF01168.20 PIK62555.1 - 7.4e-26 91.1 0.0 9e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain UPF0542 PF15086.6 PIK62555.1 - 0.15 12.0 0.3 0.64 10.0 0.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 CutC PF03932.14 PIK62556.1 - 4.4e-44 150.4 0.0 5.6e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 CutC family MRG PF05712.13 PIK62557.1 - 2.4e-42 144.5 0.0 3.4e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 PIK62557.1 - 2.3e-07 30.6 0.1 5.6e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 PIK62557.1 - 0.0012 18.7 0.3 0.0024 17.7 0.3 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CCDC53 PF10152.9 PIK62558.1 - 0.021 15.3 0.1 0.034 14.6 0.1 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PIP49_C PF12260.8 PIK62559.1 - 1.7e-09 37.6 0.0 2.5e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 TGF_beta PF00019.20 PIK62560.1 - 8.9e-23 81.3 0.4 1.4e-22 80.7 0.4 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 PIK62560.1 - 6.2e-06 26.1 0.0 7.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TPT PF03151.16 PIK62561.1 - 4.8e-75 252.6 17.8 5.4e-75 252.4 17.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 PIK62561.1 - 1.1e-20 74.3 28.5 6.2e-11 42.6 14.3 2.0 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 PIK62561.1 - 3.6e-07 29.7 15.6 4.4e-07 29.4 15.6 1.1 1 0 0 1 1 1 1 UAA transporter family TMEM234 PF10639.9 PIK62561.1 - 0.64 10.1 10.9 0.84 9.7 2.7 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 RNase_T PF00929.24 PIK62562.1 - 1.3e-36 126.7 0.0 1.5e-36 126.5 0.0 1.0 1 0 0 1 1 1 1 Exonuclease Fibrinogen_C PF00147.18 PIK62564.1 - 1.9e-10 40.9 0.0 3.1e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_3 PF12947.7 PIK62564.1 - 9.5e-05 22.5 9.9 9.5e-05 22.5 9.9 2.9 2 1 1 3 3 3 1 EGF domain EGF PF00008.27 PIK62564.1 - 0.015 15.6 5.1 0.015 15.6 5.1 3.2 3 1 1 4 4 4 0 EGF-like domain cEGF PF12662.7 PIK62564.1 - 0.021 14.7 3.0 0.021 14.7 3.0 2.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_CA PF07645.15 PIK62564.1 - 0.024 14.8 13.6 0.1 12.8 9.4 2.6 2 0 0 2 2 2 0 Calcium-binding EGF domain COLFI PF01410.18 PIK62564.1 - 0.026 13.8 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain EGF_MSP1_1 PF12946.7 PIK62564.1 - 0.091 12.8 7.5 2.9 8.0 8.2 2.8 2 1 0 2 2 2 0 MSP1 EGF domain 1 BspA_v PF18220.1 PIK62564.1 - 0.12 12.4 0.0 2.4 8.3 0.0 2.1 1 1 1 2 2 2 0 Adhesin BspA variable domain EGF_2 PF07974.13 PIK62564.1 - 0.19 12.1 13.5 0.37 11.2 9.5 2.7 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 PIK62564.1 - 0.61 10.8 7.4 0.69 10.6 4.6 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF VWD PF00094.25 PIK62565.1 - 1.9e-120 398.7 9.5 3e-31 108.8 0.5 5.3 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.11 PIK62565.1 - 2e-67 223.6 92.8 3e-16 59.6 1.6 9.5 9 1 1 10 10 10 6 C8 domain TILa PF12714.7 PIK62565.1 - 1.8e-32 111.1 111.6 4.3e-12 45.8 8.9 9.5 7 2 1 8 8 8 5 TILa domain TIL PF01826.17 PIK62565.1 - 1.3e-16 60.6 61.6 2.3e-08 34.1 15.7 15.0 12 3 3 15 15 15 4 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK62565.1 - 0.0018 18.4 27.4 0.0028 17.8 10.9 11.6 8 4 5 13 13 13 4 EGF domain RGM_C PF06534.13 PIK62565.1 - 0.22 11.0 18.9 0.16 11.5 0.8 4.3 4 0 0 4 4 4 0 Repulsive guidance molecule (RGM) C-terminus Death PF00531.22 PIK62566.1 - 2.6e-10 40.3 0.2 5.1e-10 39.4 0.2 1.4 1 0 0 1 1 1 1 Death domain SH2 PF00017.24 PIK62566.1 - 2.4e-06 27.5 0.1 4.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SMG1 PF15785.5 PIK62567.1 - 4.7e-118 395.3 0.1 4.7e-118 395.3 0.1 1.5 2 0 0 2 2 2 1 Serine/threonine-protein kinase smg-1 DUF1512 PF07431.12 PIK62568.1 - 0.027 13.5 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) HEAT PF02985.22 PIK62568.1 - 0.086 13.1 0.0 0.43 11.0 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat Lipoprotein_20 PF13942.6 PIK62568.1 - 0.44 10.5 5.1 0.31 11.0 0.5 2.5 3 0 0 3 3 3 0 YfhG lipoprotein PI3_PI4_kinase PF00454.27 PIK62569.1 - 1.4e-43 149.5 0.0 2.7e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 PIK62569.1 - 1e-05 25.8 4.9 0.0055 17.1 0.5 2.5 1 1 1 2 2 2 2 FKBP12-rapamycin binding domain RNA_binding PF01877.17 PIK62570.1 - 0.0016 18.7 0.5 0.0065 16.7 0.5 2.1 1 0 0 1 1 1 1 RNA binding Gal-3-0_sulfotr PF06990.11 PIK62571.1 - 4.6e-77 259.6 2.1 9.2e-77 258.6 2.1 1.4 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK62571.1 - 0.02 15.3 0.0 0.044 14.1 0.0 1.7 1 0 0 1 1 1 0 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 PIK62572.1 - 1.8e-70 237.8 1.0 2.3e-70 237.5 1.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Gal-3-0_sulfotr PF06990.11 PIK62573.1 - 2.1e-42 145.4 1.6 4.2e-42 144.5 1.6 1.5 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Gal-3-0_sulfotr PF06990.11 PIK62574.1 - 2.1e-12 46.6 0.0 2.2e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Kinesin PF00225.23 PIK62575.1 - 6.6e-113 377.0 0.4 1.3e-112 376.0 0.4 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK62575.1 - 6.9e-26 91.0 6.2 4.1e-25 88.5 0.1 3.2 2 1 1 3 3 3 1 Microtubule binding Methyltransf_20 PF12147.8 PIK62575.1 - 0.065 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Bac_DnaA PF00308.18 PIK62575.1 - 0.15 11.9 0.0 0.15 11.9 0.0 2.6 3 1 0 3 3 3 0 Bacterial dnaA protein Lectin_N PF03954.14 PIK62575.1 - 5.8 6.7 9.4 2.7 7.8 1.6 3.2 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain CUB PF00431.20 PIK62577.1 - 2.8e-08 34.1 0.0 1.6e-07 31.6 0.0 2.2 2 0 0 2 2 2 1 CUB domain 7tm_2 PF00002.24 PIK62577.1 - 0.0032 16.8 11.2 0.0055 16.0 11.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF3165 PF11364.8 PIK62577.1 - 0.39 11.1 7.6 0.8 10.1 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3165) DIOX_N PF14226.6 PIK62578.1 - 1.8e-20 73.9 0.0 3.1e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 PIK62578.1 - 3.1e-18 66.1 0.0 5.7e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1858 PF08984.11 PIK62578.1 - 0.015 15.5 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) zf-H2C2_2 PF13465.6 PIK62579.1 - 2.2e-62 204.9 125.1 1.1e-07 31.9 1.9 16.8 17 0 0 17 17 17 13 Zinc-finger double domain zf-C2H2 PF00096.26 PIK62579.1 - 2.8e-38 128.3 146.1 2.4e-05 24.5 1.6 17.2 18 0 0 18 18 17 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK62579.1 - 1.4e-32 109.5 132.7 0.00064 20.3 0.6 16.9 18 0 0 18 18 18 13 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK62579.1 - 4.1e-12 46.1 78.5 0.021 15.1 0.8 14.7 15 0 0 15 15 15 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK62579.1 - 1.7e-08 34.6 74.6 0.0032 17.8 0.2 15.0 15 0 0 15 15 15 6 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK62579.1 - 2.9e-06 27.1 119.7 0.00027 20.8 1.5 17.0 17 2 0 17 17 17 7 C2H2-type zinc finger BHD_1 PF10403.9 PIK62579.1 - 0.0001 22.0 3.3 0.54 10.1 0.1 4.3 3 1 1 4 4 4 1 Rad4 beta-hairpin domain 1 zf_UBZ PF18439.1 PIK62579.1 - 0.0003 20.3 65.6 1.7 8.3 0.1 14.8 15 0 0 15 15 15 6 Ubiquitin-Binding Zinc Finger BolA PF01722.18 PIK62579.1 - 0.00062 20.0 20.9 0.24 11.7 0.3 6.2 4 2 4 8 8 8 2 BolA-like protein zf-C2HE PF16278.5 PIK62579.1 - 0.024 15.1 2.6 0.024 15.1 2.6 9.3 4 2 5 9 9 8 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 PIK62579.1 - 0.024 14.4 0.1 0.024 14.4 0.1 12.7 13 1 0 13 13 13 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 PIK62579.1 - 0.042 13.6 0.6 0.042 13.6 0.6 9.6 10 0 0 10 10 10 0 zinc-finger C2H2-type GAGA PF09237.11 PIK62579.1 - 7 6.5 27.1 6.8 6.6 0.5 7.4 5 3 2 8 8 8 0 GAGA factor AAA_11 PF13086.6 PIK62580.1 - 2.3e-36 125.9 0.1 2.3e-36 125.9 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 PIK62580.1 - 1.5e-26 93.3 0.0 4.6e-14 52.5 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 PIK62580.1 - 0.00066 20.0 0.0 0.0017 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 PIK62580.1 - 0.083 13.2 0.0 0.49 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran_CTD PF16326.5 PIK62580.1 - 0.33 11.2 2.1 0.79 10.0 2.1 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain SEN1_N PF12726.7 PIK62582.1 - 0.00029 19.2 1.0 0.00038 18.8 1.0 1.1 1 0 0 1 1 1 1 SEN1 N terminal DUF1282 PF06930.12 PIK62582.1 - 0.02 14.7 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) SEN1_N PF12726.7 PIK62583.1 - 3.4e-06 25.6 3.6 0.00075 17.8 0.0 2.2 1 1 1 2 2 2 2 SEN1 N terminal RINGv PF12906.7 PIK62584.1 - 1.1e-13 51.0 10.4 2.3e-13 50.0 10.4 1.6 1 0 0 1 1 1 1 RING-variant domain Calc_CGRP_IAPP PF00214.19 PIK62584.1 - 0.083 13.2 1.0 0.22 11.9 1.0 1.7 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family I_LWEQ PF01608.17 PIK62584.1 - 0.57 10.4 3.4 2.6 8.3 0.1 2.6 3 0 0 3 3 3 0 I/LWEQ domain zf-RING_2 PF13639.6 PIK62584.1 - 0.7 10.3 11.9 0.16 12.3 7.6 2.2 2 0 0 2 2 2 0 Ring finger domain RVT_1 PF00078.27 PIK62586.1 - 3.6e-26 92.1 0.0 3.8e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_38 PF18438.1 PIK62587.1 - 0.089 12.9 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 Cys_Met_Meta_PP PF01053.20 PIK62588.1 - 1.4e-145 484.6 0.0 1.6e-145 484.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 PIK62588.1 - 0.00036 19.6 0.0 0.0011 18.0 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 PIK62588.1 - 0.00037 19.8 0.0 0.00056 19.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II GPCR_chapero_1 PF11904.8 PIK62589.1 - 2.8e-24 86.1 0.2 3.3e-24 85.9 0.2 1.0 1 0 0 1 1 1 1 GPCR-chaperone Ank_4 PF13637.6 PIK62590.1 - 4.2e-13 49.5 1.1 2.4e-07 31.2 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 PIK62590.1 - 2.7e-11 43.9 0.2 3.5e-11 43.5 0.2 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 PIK62590.1 - 3e-11 43.2 1.1 2.2e-08 34.1 1.8 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 PIK62590.1 - 1.1e-09 37.7 0.2 3e-05 24.1 0.2 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 PIK62590.1 - 6.6e-09 35.9 0.3 9.8e-09 35.3 0.3 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) SAD_SRA PF02182.17 PIK62591.1 - 1.5e-57 193.7 0.2 3e-57 192.7 0.2 1.5 1 0 0 1 1 1 1 SAD/SRA domain TTD PF12148.8 PIK62591.1 - 3.2e-56 189.5 0.2 8.6e-56 188.1 0.2 1.8 1 0 0 1 1 1 1 Tandem tudor domain within UHRF1 ubiquitin PF00240.23 PIK62591.1 - 4.7e-12 45.5 0.6 1.4e-11 44.0 0.6 1.9 1 0 0 1 1 1 1 Ubiquitin family PHD PF00628.29 PIK62591.1 - 1.8e-09 37.4 11.9 1.8e-09 37.4 11.9 3.4 2 2 1 3 3 2 1 PHD-finger Prok-RING_4 PF14447.6 PIK62591.1 - 3.1e-06 26.9 11.8 3.1e-06 26.9 11.8 3.2 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 PIK62591.1 - 9.9e-06 25.3 12.6 9.9e-06 25.3 12.6 4.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 PIK62591.1 - 6.2e-05 22.7 14.8 6.2e-05 22.7 14.8 3.3 2 1 2 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 PIK62591.1 - 0.00052 19.8 15.8 0.00052 19.8 15.8 3.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK62591.1 - 0.0026 18.1 14.1 0.0026 18.1 14.1 3.5 2 1 0 2 2 1 1 Ring finger domain Rad60-SLD PF11976.8 PIK62591.1 - 0.004 17.0 0.1 0.0093 15.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RING_5 PF14634.6 PIK62591.1 - 0.015 15.2 14.5 0.015 15.2 14.5 3.7 2 1 0 2 2 1 0 zinc-RING finger domain CCDC106 PF15794.5 PIK62591.1 - 4.9 6.8 8.5 1.3 8.7 4.4 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Lipase PF00151.19 PIK62592.1 - 4.8e-88 295.7 0.5 7.5e-88 295.1 0.5 1.3 1 1 0 1 1 1 1 Lipase DUF900 PF05990.12 PIK62592.1 - 1.7e-05 24.5 0.0 2.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 PIK62592.1 - 0.0045 17.6 0.0 0.0073 16.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 PIK62592.1 - 0.0073 15.8 0.2 0.012 15.2 0.2 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 PIK62592.1 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 PIK62592.1 - 0.051 13.4 0.1 0.074 12.9 0.1 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_2 PF02230.16 PIK62592.1 - 0.055 13.3 0.1 0.29 10.9 0.1 1.9 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_2 PF01674.18 PIK62592.1 - 0.091 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Lipase (class 2) SSF PF00474.17 PIK62593.1 - 6.8e-48 163.5 24.9 8.9e-48 163.1 24.9 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2244 PF10003.9 PIK62593.1 - 6.2 6.5 8.5 6 6.5 0.2 3.5 3 0 0 3 3 3 0 Integral membrane protein (DUF2244) SSF PF00474.17 PIK62594.1 - 3.8e-42 144.6 26.1 2.8e-30 105.5 15.6 2.2 1 1 1 2 2 2 2 Sodium:solute symporter family YTH PF04146.15 PIK62595.1 - 1.8e-33 115.8 0.0 1.8e-33 115.8 0.0 3.6 2 2 0 2 2 2 1 YT521-B-like domain BUD22 PF09073.10 PIK62595.1 - 1.6 8.0 35.0 2.1 7.6 35.0 1.2 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 PIK62595.1 - 1.9 7.0 13.3 2.4 6.6 13.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF4796 PF16044.5 PIK62596.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) LRR_4 PF12799.7 PIK62597.1 - 0.0002 21.7 0.8 0.00082 19.7 0.3 2.2 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK62597.1 - 0.001 18.8 0.3 0.0029 17.3 0.3 1.8 1 1 0 1 1 1 1 Leucine rich repeat TMEM154 PF15102.6 PIK62597.1 - 0.019 14.9 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family LRR_6 PF13516.6 PIK62597.1 - 0.82 9.9 2.3 0.83 9.9 0.1 2.3 2 0 0 2 2 2 0 Leucine Rich repeat Lectin_C PF00059.21 PIK62598.1 - 2.7e-10 41.0 0.2 4.4e-10 40.2 0.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain Calx-beta PF03160.14 PIK62598.1 - 5.3e-06 26.5 0.3 0.00017 21.7 0.1 2.7 2 1 0 2 2 2 1 Calx-beta domain Calycin_like PF13944.6 PIK62598.1 - 0.027 14.8 0.0 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 Calycin-like beta-barrel domain Oxysterol_BP PF01237.18 PIK62599.1 - 1.1e-78 264.6 9.4 1e-76 258.2 9.3 2.4 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 PIK62599.1 - 3.1e-13 50.1 0.1 8.2e-13 48.8 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 PIK62599.1 - 6.4e-07 29.6 0.1 2e-06 28.0 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 PIK62599.1 - 0.00012 22.4 7.7 0.00043 20.7 3.7 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 PIK62599.1 - 0.00079 19.7 0.1 0.0025 18.1 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 PIK62599.1 - 0.021 14.9 0.0 0.066 13.3 0.0 1.8 1 0 0 1 1 1 0 PH domain PDEase_I PF00233.19 PIK62600.1 - 1.6e-86 289.9 4.4 2.1e-86 289.5 4.4 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDE4_UCR PF18100.1 PIK62601.1 - 2.8e-49 166.7 0.1 4e-49 166.2 0.1 1.2 1 0 0 1 1 1 1 Phosphodiesterase 4 upstream conserved regions (UCR) zf-RanBP PF00641.18 PIK62602.1 - 6.6e-10 38.1 16.1 4.9e-05 22.5 1.9 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 PIK62602.1 - 0.08 12.8 7.7 0.49 10.3 1.0 2.4 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RecR PF02132.15 PIK62602.1 - 4.3 7.0 7.4 2.1 8.0 0.7 2.6 2 0 0 2 2 2 0 RecR protein VCBS PF13517.6 PIK62603.1 - 8e-14 52.0 11.0 7.4e-05 23.3 1.0 3.8 3 0 0 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 PIK62603.1 - 0.00018 21.5 17.8 0.0016 18.5 0.3 4.6 5 0 0 5 5 5 3 FG-GAP repeat EF-hand_5 PF13202.6 PIK62603.1 - 0.27 10.8 7.0 3.2 7.4 0.1 4.2 4 0 0 4 4 4 0 EF hand EF-hand_1 PF00036.32 PIK62603.1 - 9.1 6.1 8.4 21 5.0 0.1 3.8 4 0 0 4 4 4 0 EF hand Y_phosphatase PF00102.27 PIK62604.1 - 2e-112 374.5 7.9 1.6e-72 243.9 1.8 3.7 3 1 1 4 4 4 3 Protein-tyrosine phosphatase fn3 PF00041.21 PIK62604.1 - 3.8e-31 107.3 6.0 2.2e-14 53.6 0.6 4.7 4 0 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK62604.1 - 3.6e-06 27.4 5.0 0.015 15.9 0.0 4.1 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Y_phosphatase3 PF13350.6 PIK62604.1 - 5.9e-06 26.4 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 PIK62604.1 - 0.0041 16.9 0.2 0.037 13.9 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 PIK62604.1 - 0.055 13.1 0.4 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family FtsH_ext PF06480.15 PIK62604.1 - 0.11 12.9 0.8 0.29 11.5 0.1 2.1 2 0 0 2 2 2 0 FtsH Extracellular fn3 PF00041.21 PIK62605.1 - 1.3e-20 73.6 0.1 3.8e-06 27.2 0.0 3.6 3 0 0 3 3 3 3 Fibronectin type III domain zf-U11-48K PF05253.12 PIK62607.1 - 0.0075 16.2 10.6 0.95 9.5 0.1 4.2 4 0 0 4 4 4 3 U11-48K-like CHHC zinc finger Thy1 PF02511.15 PIK62607.1 - 0.065 13.0 0.1 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Thymidylate synthase complementing protein RhoGAP PF00620.27 PIK62608.1 - 2.3e-35 121.6 0.1 2.3e-35 121.6 0.1 1.7 2 0 0 2 2 2 1 RhoGAP domain SH2 PF00017.24 PIK62608.1 - 1.9e-31 108.0 0.1 5e-16 58.6 0.1 2.6 2 0 0 2 2 2 2 SH2 domain PI3K_P85_iSH2 PF16454.5 PIK62608.1 - 1.1e-28 99.8 11.1 2.3e-28 98.8 11.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SAM_1 PF00536.30 PIK62608.1 - 1.7e-10 41.2 0.1 5.6e-10 39.5 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) C1_1 PF00130.22 PIK62608.1 - 5.6e-09 35.8 7.1 1.3e-06 28.2 9.5 2.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_2 PF07647.17 PIK62608.1 - 1.6e-08 34.5 0.1 5.4e-08 32.8 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHD PF00628.29 PIK62608.1 - 5.1 7.1 8.6 8.5 6.4 6.0 2.7 3 0 0 3 3 3 0 PHD-finger Herpes_BLLF1 PF05109.13 PIK62609.1 - 0.015 13.4 6.0 0.021 12.8 6.0 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RNase_HII PF01351.18 PIK62610.1 - 0.035 14.0 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease HII Ig_3 PF13927.6 PIK62612.1 - 0.001 19.6 3.4 0.0019 18.8 1.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 PIK62612.1 - 0.021 14.9 1.1 0.17 12.0 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin I-set domain ig PF00047.25 PIK62612.1 - 0.025 14.7 2.3 0.057 13.6 0.6 2.6 2 0 0 2 2 2 0 Immunoglobulin domain PAS_6 PF08348.11 PIK62612.1 - 0.96 9.3 6.7 0.9 9.4 0.7 2.9 3 0 0 3 3 3 0 YheO-like PAS domain TMEM154 PF15102.6 PIK62613.1 - 0.023 14.6 3.5 0.027 14.4 0.4 2.4 2 0 0 2 2 2 0 TMEM154 protein family Endomucin PF07010.12 PIK62613.1 - 0.76 9.7 5.2 0.37 10.7 1.6 2.2 2 0 0 2 2 2 0 Endomucin Synaptobrevin PF00957.21 PIK62614.1 - 0.056 13.2 0.4 0.096 12.5 0.3 1.6 1 1 0 1 1 1 0 Synaptobrevin TMEM154 PF15102.6 PIK62614.1 - 0.28 11.1 2.9 0.25 11.3 1.7 1.5 1 1 0 1 1 1 0 TMEM154 protein family Peptidase_M10 PF00413.24 PIK62615.1 - 6.5e-53 178.8 0.0 1e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 PIK62615.1 - 6e-28 96.5 18.3 7e-08 32.3 0.1 4.5 4 0 0 4 4 4 4 Hemopexin Reprolysin_5 PF13688.6 PIK62615.1 - 0.008 16.3 0.1 0.013 15.7 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 PIK62615.1 - 0.012 16.1 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 PIK62615.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 PIK62615.1 - 0.041 13.1 0.1 0.067 12.4 0.1 1.3 1 0 0 1 1 1 0 Met-zincin Metallopep PF12044.8 PIK62615.1 - 0.044 12.4 0.0 0.068 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Astacin PF01400.24 PIK62615.1 - 0.076 12.6 0.1 0.69 9.5 0.0 2.0 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.9 PIK62615.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M54 PF07998.11 PIK62615.1 - 0.15 12.1 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M54 GFO_IDH_MocA PF01408.22 PIK62616.1 - 3.2e-18 66.7 0.0 6.6e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 PIK62616.1 - 9.6e-06 25.6 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 PIK62616.1 - 0.0013 19.2 0.0 0.0024 18.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 PIK62616.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_3 PF03447.16 PIK62616.1 - 0.015 16.0 0.0 0.023 15.4 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain ATG16 PF08614.11 PIK62617.1 - 1.5e-06 28.6 371.5 0.0004 20.7 8.6 17.5 1 1 15 16 16 16 7 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 PIK62617.1 - 0.00024 21.0 28.1 0.00024 21.0 28.1 14.9 4 3 10 14 14 14 3 Coiled-coil region of CCDC155 or KASH EzrA PF06160.12 PIK62617.1 - 0.00053 18.3 32.3 0.00053 18.3 32.3 11.3 3 1 3 9 9 9 2 Septation ring formation regulator, EzrA Fez1 PF06818.15 PIK62617.1 - 0.0014 19.1 323.3 0.57 10.6 17.8 14.4 1 1 11 13 13 13 7 Fez1 Golgin_A5 PF09787.9 PIK62617.1 - 0.0015 18.0 20.7 0.0015 18.0 20.7 14.9 1 1 14 15 15 15 4 Golgin subfamily A member 5 AAA_13 PF13166.6 PIK62617.1 - 0.002 16.8 35.0 0.002 16.8 35.0 10.6 2 2 7 10 10 10 4 AAA domain GAS PF13851.6 PIK62617.1 - 0.0032 16.8 15.2 0.0032 16.8 15.2 16.9 3 2 12 17 17 17 6 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 PIK62617.1 - 0.0062 16.8 10.5 0.0062 16.8 10.5 16.3 7 4 8 16 16 16 3 Domain of unknown function (DUF5082) FlaC_arch PF05377.11 PIK62617.1 - 0.019 15.3 0.8 0.019 15.3 0.8 25.9 21 8 7 28 28 28 0 Flagella accessory protein C (FlaC) NTP_transf_2 PF01909.23 PIK62617.1 - 0.14 12.4 2.6 3 8.2 0.0 4.8 3 0 0 3 3 3 0 Nucleotidyltransferase domain DUF4201 PF13870.6 PIK62618.1 - 0.00022 21.0 9.7 0.00022 21.0 9.7 3.5 1 1 2 3 3 3 1 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 PIK62618.1 - 0.00086 18.9 23.5 0.00086 18.9 23.5 2.4 1 1 1 2 2 2 1 Golgin subfamily A member 5 KASH_CCD PF14662.6 PIK62618.1 - 0.0014 18.5 43.2 0.023 14.6 20.9 3.1 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 PIK62618.1 - 0.0022 17.0 43.7 0.021 13.8 13.2 3.1 1 1 1 3 3 3 2 Spc7 kinetochore protein Myosin_tail_1 PF01576.19 PIK62618.1 - 0.0039 15.1 45.0 0.0046 14.8 45.0 1.1 1 0 0 1 1 1 1 Myosin tail Fez1 PF06818.15 PIK62618.1 - 0.028 14.9 9.1 0.028 14.9 9.1 2.7 1 1 1 2 2 2 0 Fez1 BRE1 PF08647.11 PIK62618.1 - 0.037 14.1 41.5 0.38 10.9 8.8 3.6 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 PIK62618.1 - 0.044 13.1 43.8 0.54 9.6 12.8 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 PIK62618.1 - 0.059 13.6 42.8 0.074 13.3 17.5 4.1 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding HOOK PF05622.12 PIK62618.1 - 0.25 9.4 40.7 0.28 9.3 40.7 1.1 1 0 0 1 1 1 0 HOOK protein ATG16 PF08614.11 PIK62618.1 - 0.46 10.7 49.0 0.3 11.3 13.6 3.6 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 PIK62618.1 - 0.51 9.6 43.6 0.12 11.7 7.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TMCO5 PF14992.6 PIK62618.1 - 0.6 9.6 37.9 0.83 9.2 19.9 2.8 1 1 1 2 2 2 0 TMCO5 family Filament PF00038.21 PIK62618.1 - 0.61 9.6 39.6 0.17 11.4 9.3 3.2 1 1 2 3 3 3 0 Intermediate filament protein DUF4407 PF14362.6 PIK62618.1 - 0.66 9.3 28.3 0.073 12.4 16.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.5 PIK62618.1 - 0.79 10.7 39.5 0.13 13.2 15.9 3.7 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 PIK62618.1 - 0.96 10.1 32.4 0.13 12.9 3.9 3.9 1 1 2 3 3 3 0 Initiation control protein YabA ZapB PF06005.12 PIK62618.1 - 1 9.9 44.7 0.095 13.2 2.8 5.1 1 1 3 4 4 3 0 Cell division protein ZapB SHE3 PF17078.5 PIK62618.1 - 2 8.1 32.7 1.7 8.3 26.3 2.9 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 APH PF01636.23 PIK62618.1 - 3.5 7.5 8.8 11 5.9 8.7 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF16 PF01519.16 PIK62618.1 - 6.1 7.4 31.2 0.21 12.1 9.1 3.6 2 2 1 3 3 3 0 Protein of unknown function DUF16 APG6_N PF17675.1 PIK62618.1 - 9.4 6.8 48.0 0.14 12.7 21.0 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4674 PF15719.5 PIK62619.1 - 3.1e-06 27.4 24.7 1.2e-05 25.5 24.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4674) Arg_decarbox_C PF17944.1 PIK62619.1 - 0.11 13.0 0.7 1.7 9.2 0.1 2.3 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension COMMD1_N PF17221.3 PIK62619.1 - 0.13 12.6 3.1 0.24 11.7 0.1 2.1 2 0 0 2 2 2 0 COMMD1 N-terminal domain PIG-U PF06728.13 PIK62620.1 - 3.4e-97 325.9 46.3 2.9e-77 260.3 42.3 2.1 1 1 1 2 2 2 2 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 PIK62620.1 - 2.2 7.9 31.0 24 4.5 30.9 2.5 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain LSM14 PF12701.7 PIK62621.1 - 1.4e-26 92.4 0.0 2.4e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 PIK62621.1 - 2.1e-09 38.2 8.3 2.1e-09 38.2 8.3 3.1 2 1 0 2 2 2 1 FDF domain SM-ATX PF14438.6 PIK62621.1 - 0.0032 17.6 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain Caprin-1_C PF12287.8 PIK62621.1 - 0.0062 16.7 13.4 0.0062 16.7 13.4 1.9 2 0 0 2 2 2 1 Cytoplasmic activation/proliferation-associated protein-1 C term RNase_PH PF01138.21 PIK62622.1 - 1.1e-37 129.5 0.0 1.5e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 PIK62622.1 - 1.4e-07 31.4 0.0 3.1e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Homeodomain PF00046.29 PIK62623.1 - 2.7e-65 216.1 16.2 2.7e-17 62.3 0.5 5.2 4 0 0 4 4 4 4 Homeodomain zf-C2H2_4 PF13894.6 PIK62623.1 - 5.4e-18 64.1 156.9 0.035 14.9 0.7 25.1 26 0 0 26 26 25 13 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK62623.1 - 2e-15 56.3 175.5 0.0044 17.4 0.6 23.5 25 0 0 25 25 23 13 Zinc finger, C2H2 type zf-met PF12874.7 PIK62623.1 - 9.8e-12 44.9 100.6 0.0015 18.8 0.8 17.7 18 0 0 18 18 18 8 Zinc-finger of C2H2 type Homeobox_KN PF05920.11 PIK62623.1 - 1.7e-10 40.6 2.8 0.011 15.6 0.0 5.5 5 0 0 5 5 5 2 Homeobox KN domain zf-C2H2_jaz PF12171.8 PIK62623.1 - 3.9e-09 36.6 99.9 0.0016 18.7 0.5 18.5 19 0 0 19 19 18 7 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK62623.1 - 9.4e-06 25.8 15.1 4.3e-05 23.7 7.1 14.9 17 1 0 17 17 16 4 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 PIK62623.1 - 0.00026 20.7 7.4 0.0016 18.1 0.7 12.2 12 0 0 12 12 11 5 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 PIK62623.1 - 0.025 14.6 86.3 0.098 12.7 0.1 13.8 14 0 0 14 14 14 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 PIK62623.1 - 0.081 13.3 135.9 0.17 12.2 9.3 19.6 14 6 4 18 18 18 0 C2H2 type zinc-finger (2 copies) Arrestin_C PF02752.22 PIK62623.1 - 0.11 12.9 3.5 0.33 11.4 1.0 3.3 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain zf-RING_7 PF02591.15 PIK62623.1 - 1.3 9.2 6.3 65 3.8 0.3 5.2 3 0 0 3 3 3 0 C4-type zinc ribbon domain CDKN3 PF05706.12 PIK62624.1 - 2e-10 40.6 2.6 1.7 8.3 0.1 5.9 1 1 6 7 7 7 7 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF4461 PF14688.6 PIK62625.1 - 3.7e-27 95.9 3.8 6e-27 95.3 3.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) DUF4460 PF14687.6 PIK62625.1 - 2.9e-26 91.7 0.0 6.4e-26 90.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF1295 PF06966.12 PIK62626.1 - 3.1e-76 256.0 1.4 3.7e-76 255.8 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 PIK62626.1 - 1.6e-06 28.2 1.9 1.6e-06 28.2 1.9 2.3 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 PIK62626.1 - 0.001 19.4 0.3 0.001 19.4 0.3 2.3 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 PIK62626.1 - 0.0013 19.1 0.0 0.0013 19.1 0.0 2.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AA_permease_2 PF13520.6 PIK62627.1 - 0.0047 15.8 7.5 0.0056 15.6 7.5 1.2 1 0 0 1 1 1 1 Amino acid permease DUF1614 PF07758.11 PIK62627.1 - 0.024 14.7 0.6 0.031 14.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) PseudoU_synth_2 PF00849.22 PIK62628.1 - 2.1e-30 105.9 0.1 3.7e-30 105.1 0.1 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 PIK62628.1 - 0.0073 16.0 0.0 0.023 14.4 0.0 1.9 1 0 0 1 1 1 1 S4 domain Cofilin_ADF PF00241.20 PIK62629.1 - 2.3e-22 79.0 0.1 2.8e-22 78.8 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ParcG PF10274.9 PIK62629.1 - 0.097 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Parkin co-regulated protein E3_UbLigase_RBR PF18091.1 PIK62631.1 - 6.7e-08 32.6 0.0 1.6e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 E3 Ubiquitin Ligase RBR C-terminal domain PUB PF09409.10 PIK62631.1 - 1.9e-07 30.9 0.0 4.6e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 PUB domain zf-B_box PF00643.24 PIK62631.1 - 0.00026 21.1 10.9 0.00026 21.1 10.9 3.7 3 0 0 3 3 3 2 B-box zinc finger IBR PF01485.21 PIK62631.1 - 0.022 15.0 43.2 0.28 11.4 4.7 4.2 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Tiam_CC_Ex PF18385.1 PIK62631.1 - 0.084 13.3 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain DUF4062 PF13271.6 PIK62632.1 - 0.18 12.2 0.0 0.41 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) RVT_1 PF00078.27 PIK62633.1 - 8.9e-13 48.3 0.0 1.2e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAD PF03068.15 PIK62633.1 - 0.0054 15.8 0.0 0.0071 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) MATalpha_HMGbox PF04769.12 PIK62633.1 - 0.02 14.2 0.0 0.042 13.1 0.0 1.5 2 0 0 2 2 2 0 Mating-type protein MAT alpha 1 HMG-box AIG1 PF04548.16 PIK62634.1 - 4.7e-05 22.8 0.6 4.7e-05 22.8 0.6 2.7 2 2 1 3 3 3 2 AIG1 family Med10 PF09748.9 PIK62634.1 - 0.0011 18.9 1.4 0.0011 18.9 1.4 1.8 1 1 0 2 2 2 1 Transcription factor subunit Med10 of Mediator complex DUF4011 PF13195.6 PIK62634.1 - 1.1 9.2 10.2 1.1 9.2 9.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4011) LMBR1 PF04791.16 PIK62634.1 - 3.8 6.3 7.5 4 6.2 7.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein E3_UbLigase_RBR PF18091.1 PIK62635.1 - 2.7e-25 88.3 0.5 3.2e-24 84.9 0.0 3.0 3 0 0 3 3 3 1 E3 Ubiquitin Ligase RBR C-terminal domain IBR PF01485.21 PIK62635.1 - 2e-09 37.5 27.7 1.1e-08 35.1 8.3 4.8 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain HOIP-UBA PF16678.5 PIK62635.1 - 0.00032 20.8 0.1 0.00085 19.4 0.1 1.7 1 0 0 1 1 1 1 HOIP UBA domain pair PNMA PF14893.6 PIK62636.1 - 4.2e-05 23.1 0.4 7.1e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 PNMA UIM PF02809.20 PIK62636.1 - 0.015 15.2 0.1 0.12 12.4 0.1 2.7 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF2205 PF10224.9 PIK62636.1 - 1 9.4 4.6 5 7.2 0.0 3.2 3 2 0 3 3 3 0 Short coiled-coil protein Topoisom_I PF01028.20 PIK62637.1 - 3.9e-65 219.3 5.6 3.9e-65 219.3 5.6 2.0 1 1 1 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 PIK62637.1 - 3.4e-23 81.4 3.3 1e-22 79.8 3.3 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain LCIB_C_CA PF18599.1 PIK62637.1 - 0.0096 15.2 0.8 0.016 14.5 0.8 1.4 1 0 0 1 1 1 1 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DUF4407 PF14362.6 PIK62637.1 - 0.025 13.9 1.5 0.034 13.5 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPAT_C PF15712.5 PIK62637.1 - 0.15 10.7 3.4 0.2 10.3 3.4 1.1 1 0 0 1 1 1 0 NPAT C terminus IFT20 PF14931.6 PIK62637.1 - 0.41 10.8 9.7 0.54 10.4 8.3 1.9 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 ASL_C PF08328.11 PIK62637.1 - 1.2 9.3 6.9 28 4.8 4.5 2.6 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminal FlxA PF14282.6 PIK62637.1 - 4.6 7.3 10.5 0.63 10.1 6.2 1.8 2 0 0 2 2 2 0 FlxA-like protein Atg14 PF10186.9 PIK62637.1 - 8.1 5.4 12.2 21 4.1 12.1 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Topoisom_I PF01028.20 PIK62638.1 - 8.4e-98 326.2 6.9 8.4e-98 326.2 6.9 1.8 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 PIK62638.1 - 3.6e-63 212.9 8.2 8.6e-39 133.3 2.8 4.2 3 1 1 4 4 4 2 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 PIK62638.1 - 1.7e-18 66.3 0.3 7.2e-18 64.3 0.3 2.1 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4094 PF13334.6 PIK62638.1 - 0.017 15.6 1.4 0.017 15.6 1.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Arch_fla_DE PF04659.13 PIK62638.1 - 0.056 13.3 0.0 0.27 11.1 0.0 2.2 1 0 0 1 1 1 0 Archaeal flagella protein LCIB_C_CA PF18599.1 PIK62638.1 - 0.09 12.1 4.3 0.031 13.6 1.2 1.8 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DUF1664 PF07889.12 PIK62638.1 - 0.45 10.6 3.9 1.1 9.3 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 PIK62638.1 - 1.3 8.3 7.0 3.3 7.0 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMG_box PF00505.19 PIK62639.1 - 2.4e-17 63.1 1.2 4.2e-17 62.3 1.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK62639.1 - 9e-13 48.6 1.7 2.2e-12 47.4 1.7 1.6 1 0 0 1 1 1 1 HMG-box domain MlaC PF05494.12 PIK62639.1 - 0.055 13.2 0.1 0.081 12.7 0.1 1.2 1 0 0 1 1 1 0 MlaC protein YABBY PF04690.13 PIK62639.1 - 0.51 10.9 5.6 0.2 12.2 2.7 1.7 1 1 1 2 2 2 0 YABBY protein Ldl_recept_a PF00057.18 PIK62641.1 - 3.1e-07 30.5 29.6 2.2e-06 27.7 8.6 2.7 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Crisp PF08562.10 PIK62641.1 - 4 8.1 22.0 7 7.3 7.2 2.4 2 0 0 2 2 2 0 Crisp Ldl_recept_a PF00057.18 PIK62642.1 - 1.2e-05 25.4 27.7 0.00076 19.7 9.9 3.0 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A Mito_carr PF00153.27 PIK62643.1 - 1.4e-43 146.8 1.5 1.1e-19 70.2 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 PIK62645.1 - 2e-42 143.0 0.2 6.2e-21 74.1 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Retrotran_gag_2 PF14223.6 PIK62646.1 - 0.00069 19.3 2.4 0.0011 18.6 2.4 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF2524 PF10732.9 PIK62646.1 - 0.12 12.7 2.4 0.36 11.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Pkinase_Tyr PF07714.17 PIK62648.1 - 4.4e-72 242.5 0.0 8.6e-72 241.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase ANF_receptor PF01094.28 PIK62648.1 - 7.4e-38 130.5 0.8 9e-38 130.3 0.1 1.4 2 0 0 2 2 2 1 Receptor family ligand binding region Pkinase PF00069.25 PIK62648.1 - 1.8e-31 109.5 0.0 3.3e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Peripla_BP_6 PF13458.6 PIK62648.1 - 3.3e-05 23.7 0.0 7.9e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Periplasmic binding protein Kinase-like PF14531.6 PIK62648.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like UDPGT PF00201.18 PIK62649.1 - 1.1e-71 242.1 0.1 1.3e-71 242.0 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 PIK62649.1 - 0.00047 20.2 0.0 0.00068 19.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Prominin PF05478.11 PIK62649.1 - 0.0011 17.1 1.6 0.0015 16.6 1.6 1.1 1 0 0 1 1 1 1 Prominin HemY_N PF07219.13 PIK62649.1 - 0.0092 16.2 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 HemY protein N-terminus WD40 PF00400.32 PIK62650.1 - 9.9e-15 54.7 20.6 0.00046 20.9 0.7 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK62650.1 - 1.8e-09 37.8 3.0 0.0023 18.2 0.0 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 PIK62650.1 - 6e-09 35.3 3.1 0.035 13.1 0.5 3.7 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 PIK62650.1 - 0.21 9.5 1.8 0.95 7.4 0.4 2.1 2 1 0 2 2 2 0 IKI3 family Ricin_B_lectin PF00652.22 PIK62651.1 - 0.00018 21.8 15.1 0.024 14.9 2.1 3.2 1 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 PIK62651.1 - 0.0078 16.9 0.0 1.2 9.9 0.0 2.9 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Herpes_BMRF2 PF04633.12 PIK62651.1 - 0.2 10.9 0.2 0.31 10.2 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus BMRF2 protein Ricin_B_lectin PF00652.22 PIK62652.1 - 0.0015 18.8 12.9 0.0044 17.3 1.8 3.1 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain Nudix_N_2 PF14803.6 PIK62652.1 - 1.6 8.7 5.5 9.1 6.3 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal RVT_1 PF00078.27 PIK62654.1 - 7.4e-05 22.4 0.1 9.3e-05 22.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAS_3 PF08447.12 PIK62654.1 - 0.13 12.6 0.0 0.36 11.1 0.0 1.7 2 0 0 2 2 2 0 PAS fold Pkinase_Tyr PF07714.17 PIK62655.1 - 1.5e-82 276.8 0.0 2.3e-82 276.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62655.1 - 6e-40 137.3 0.0 1.8e-39 135.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain MAM PF00629.23 PIK62655.1 - 5.5e-31 107.6 0.0 9.3e-31 106.9 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 PIK62655.1 - 8.1e-05 22.8 7.0 0.00019 21.6 7.0 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A APH PF01636.23 PIK62655.1 - 0.16 11.9 0.0 0.78 9.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF4381 PF14316.6 PIK62655.1 - 0.23 11.7 0.1 0.45 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) U83 PF17465.2 PIK62656.1 - 0.1 12.7 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Chemokine-like protein, HHV-6 U83 gene product CDC4_D PF16856.5 PIK62656.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain Cpn60_TCP1 PF00118.24 PIK62657.1 - 1.1e-38 133.1 0.2 1.5e-38 132.7 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TPR_19 PF14559.6 PIK62658.1 - 0.00047 20.6 0.0 0.067 13.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 PIK62658.1 - 0.00097 18.9 0.1 18 5.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 PIK62658.1 - 0.033 14.4 0.2 66 4.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 PIK62658.1 - 0.047 13.4 0.0 6.7 6.5 0.0 3.0 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.17 PIK62658.1 - 0.047 13.8 6.0 29 5.1 0.0 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 PIK62658.1 - 0.053 13.9 0.0 1.1 9.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DnaJ PF00226.31 PIK62659.1 - 6.2e-25 87.1 3.8 2e-24 85.4 3.8 2.0 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 PIK62659.1 - 2.8e-05 23.9 5.8 4.2e-05 23.3 0.0 3.4 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK62659.1 - 0.066 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prominin PF05478.11 PIK62659.1 - 0.15 10.0 2.9 0.21 9.5 2.9 1.1 1 0 0 1 1 1 0 Prominin DUF5082 PF16888.5 PIK62659.1 - 3.1 8.1 15.6 0.041 14.2 5.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Lamp PF01299.17 PIK62660.1 - 2.4e-14 53.4 0.0 4e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 PIK62660.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.6 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Rota_NS26 PF01525.16 PIK62660.1 - 0.18 11.8 3.6 0.048 13.7 0.6 1.6 2 0 0 2 2 2 0 Rotavirus NS26 FAF PF11250.8 PIK62661.1 - 0.047 13.9 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 Fantastic Four meristem regulator JAMP PF05571.12 PIK62662.1 - 7.2e-106 354.1 14.7 8.1e-106 353.9 14.7 1.0 1 0 0 1 1 1 1 JNK1/MAPK8-associated membrane protein V-SNARE PF05008.15 PIK62663.1 - 8.6e-14 51.7 1.5 2.1e-13 50.4 1.5 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 PIK62663.1 - 9.3e-14 51.5 3.9 9.3e-14 51.5 3.9 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 PIK62663.1 - 0.0002 21.2 0.8 0.00086 19.2 0.7 2.2 1 1 0 1 1 1 1 Sec20 Bcr-Abl_Oligo PF09036.10 PIK62663.1 - 0.022 14.8 0.3 0.76 9.8 0.0 2.6 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Cnn_1N PF07989.11 PIK62663.1 - 2.3 8.4 6.9 8.2 6.7 0.4 3.2 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 ThiD2 PF17792.1 PIK62663.1 - 2.6 8.5 7.9 0.73 10.3 1.3 2.5 2 1 1 3 3 3 0 ThiD2 family HIP1_clath_bdg PF16515.5 PIK62663.1 - 3.1 8.5 6.4 24 5.6 0.1 3.2 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CCDC-167 PF15188.6 PIK62663.1 - 3.8 7.9 8.4 4.3 7.7 0.2 3.1 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 p450 PF00067.22 PIK62664.1 - 1.2e-05 24.2 0.1 1.6e-05 23.9 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Neurensin PF14927.6 PIK62664.1 - 0.0055 16.4 0.2 0.0059 16.3 0.2 1.2 1 0 0 1 1 1 1 Neurensin Sid-5 PF17204.3 PIK62664.1 - 0.93 9.7 4.1 0.29 11.3 0.8 1.8 2 0 0 2 2 2 0 Sid-5 family p450 PF00067.22 PIK62665.1 - 1e-31 110.3 0.4 1.2e-31 110.0 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62666.1 - 2.9e-55 187.9 7.2 1.6e-28 99.7 0.3 3.0 2 1 1 3 3 3 3 Cytochrome P450 Glyco_hydro_10 PF00331.20 PIK62666.1 - 0.12 11.6 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 p450 PF00067.22 PIK62667.1 - 2.4e-91 306.8 0.0 2.8e-91 306.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62668.1 - 1.9e-91 307.1 0.3 2.5e-91 306.8 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62669.1 - 4.5e-67 226.8 0.2 5.4e-67 226.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 EspA PF03433.13 PIK62669.1 - 0.096 12.5 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 EspA-like secreted protein SANTA PF09133.10 PIK62670.1 - 1e-20 74.0 0.0 3.4e-20 72.3 0.0 2.0 1 0 0 1 1 1 1 SANTA (SANT Associated) Myb_DNA-binding PF00249.31 PIK62670.1 - 0.0018 18.5 0.6 0.0018 18.5 0.6 2.4 3 0 0 3 3 3 1 Myb-like DNA-binding domain TAF PF02969.17 PIK62671.1 - 4.7e-19 68.3 0.0 9.9e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 PIK62671.1 - 1.4e-16 60.6 0.0 4.5e-16 59.0 0.0 1.9 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Phage_TAC_10 PF10963.8 PIK62671.1 - 0.084 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Phage tail assembly chaperone Syntaxin-18_N PF10496.9 PIK62671.1 - 1.5 9.1 5.0 7.1 6.9 0.5 3.3 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus Atg8 PF02991.16 PIK62672.1 - 9.2e-41 138.2 0.6 1.1e-40 138.0 0.6 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 PIK62672.1 - 3e-05 24.3 0.2 4.4e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 TALPID3 PF15324.6 PIK62673.1 - 2.1e-75 254.4 110.6 6.4e-37 126.9 40.4 5.9 3 2 1 4 4 4 3 Hedgehog signalling target rve PF00665.26 PIK62674.1 - 1.3e-23 83.5 0.0 2.5e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62674.1 - 1.3e-10 41.2 1.2 3.7e-10 39.7 1.2 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 PIK62674.1 - 0.0052 17.0 1.0 0.013 15.7 1.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 PIK62674.1 - 0.0073 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MycE_N PF17843.1 PIK62674.1 - 0.029 14.8 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 MycE methyltransferase N-terminal RT_RNaseH_2 PF17919.1 PIK62675.1 - 1.9e-37 127.3 0.1 3.2e-37 126.6 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62675.1 - 9.2e-34 115.9 0.1 1.7e-33 115.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62675.1 - 2.4e-31 109.0 0.0 3.8e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.13 PIK62675.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase Asp_protease PF09668.10 PIK62676.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 PIK62677.1 - 1e-07 31.7 1.9 2.3e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 PIK62677.1 - 0.00036 20.3 0.1 0.00036 20.3 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 PIK62677.1 - 0.13 12.0 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2120 PF09893.9 PIK62677.1 - 0.19 11.8 0.3 0.45 10.6 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) zf-CCHC_4 PF14392.6 PIK62677.1 - 0.24 11.2 0.5 0.5 10.1 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-Tim10_DDP PF02953.15 PIK62678.1 - 7e-15 54.4 2.4 9.9e-15 54.0 2.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger FANCI_S3 PF14677.6 PIK62678.1 - 0.0026 17.5 0.8 0.0029 17.4 0.8 1.1 1 0 0 1 1 1 1 FANCI solenoid 3 Ras PF00071.22 PIK62679.1 - 7.7e-34 116.6 0.1 9.9e-34 116.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK62679.1 - 1.2e-22 80.4 0.0 1.9e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK62679.1 - 1e-06 28.3 0.1 1.3e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 PIK62679.1 - 0.0029 17.4 0.1 0.0037 17.1 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.5 PIK62679.1 - 0.0039 17.2 0.1 0.0068 16.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Spond_N PF06468.13 PIK62679.1 - 0.052 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Spondin_N GTP_EFTU PF00009.27 PIK62679.1 - 0.081 12.5 0.0 0.2 11.1 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TMEM251 PF15190.6 PIK62680.1 - 3.9e-20 72.1 1.8 4.3e-20 72.0 1.8 1.1 1 0 0 1 1 1 1 Transmembrane protein 251 JAB PF01398.21 PIK62682.1 - 0.16 12.0 0.7 17 5.4 0.3 3.4 1 1 1 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DFF-C PF09033.10 PIK62684.1 - 0.031 14.2 4.8 0.93 9.4 5.5 2.1 1 1 1 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain Atg14 PF10186.9 PIK62684.1 - 0.81 8.7 7.2 0.5 9.4 3.4 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nucleo_P87 PF07267.11 PIK62685.1 - 0.36 9.6 6.1 0.38 9.6 6.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Adeno_PV PF03910.13 PIK62685.1 - 0.38 9.4 7.2 0.45 9.2 7.2 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV CDC27 PF09507.10 PIK62685.1 - 0.63 9.4 13.5 0.68 9.3 13.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cwf_Cwc_15 PF04889.12 PIK62685.1 - 0.92 9.2 13.3 1.1 9.0 13.3 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIE-A_C PF11521.8 PIK62685.1 - 7.4 7.0 11.0 4 7.8 9.1 1.5 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Na_Ca_ex PF01699.24 PIK62686.1 - 2.5e-05 24.3 11.6 0.002 18.1 6.5 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 PIK62686.1 - 0.00045 20.3 0.2 0.0011 19.1 0.2 1.7 1 0 0 1 1 1 1 Calx-beta domain Calx-beta PF03160.14 PIK62687.1 - 3.1e-52 174.9 4.3 2.3e-31 107.9 0.4 2.6 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex_C PF16494.5 PIK62687.1 - 2.5e-38 131.4 3.0 4e-38 130.7 3.0 1.3 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Na_Ca_ex PF01699.24 PIK62687.1 - 1.7e-29 102.7 13.8 2.6e-29 102.1 13.8 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein HTH_WhiA PF02650.14 PIK62687.1 - 0.034 14.5 0.7 0.1 13.0 0.2 2.0 2 0 0 2 2 2 0 WhiA C-terminal HTH domain Phage_holin_3_6 PF07332.11 PIK62687.1 - 1.1 9.3 6.7 0.57 10.2 1.8 2.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Pkinase PF00069.25 PIK62688.1 - 5.6e-55 186.5 0.0 5.6e-55 186.5 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62688.1 - 2.1e-28 99.3 0.0 5.2e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase KELK PF15796.5 PIK62688.1 - 1.5e-15 57.4 26.8 1.5e-15 57.4 26.8 6.6 5 2 1 6 6 3 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase CNH PF00780.22 PIK62688.1 - 1.5e-08 34.6 0.9 0.0032 17.1 0.1 2.6 2 0 0 2 2 2 2 CNH domain C1_1 PF00130.22 PIK62688.1 - 2.9e-08 33.5 6.7 8.2e-08 32.0 6.7 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 PIK62688.1 - 3.4e-06 26.6 0.0 3.4e-06 26.6 0.0 3.1 3 1 0 3 3 1 1 Kinase-like DMPK_coil PF08826.10 PIK62688.1 - 1.6e-05 24.9 12.3 1.6e-05 24.9 12.3 7.7 6 1 3 9 9 5 2 DMPK coiled coil domain like Pkinase_C PF00433.24 PIK62688.1 - 0.00031 21.4 3.2 0.00031 21.4 3.2 2.5 2 0 0 2 2 2 1 Protein kinase C terminal domain PH PF00169.29 PIK62688.1 - 0.0084 16.6 0.0 0.032 14.7 0.0 2.2 1 0 0 1 1 1 1 PH domain APH PF01636.23 PIK62688.1 - 0.06 13.3 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family PBD PF00786.28 PIK62688.1 - 0.067 13.6 0.5 0.35 11.3 0.5 2.3 1 0 0 1 1 1 0 P21-Rho-binding domain C1_2 PF03107.16 PIK62688.1 - 0.76 10.1 4.1 2.1 8.7 4.1 1.8 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 PIK62688.1 - 3.2 7.7 7.4 7.2 6.6 7.4 1.6 1 0 0 1 1 1 0 PHD-finger DUF1345 PF07077.11 PIK62689.1 - 3.9 7.1 10.3 2.1 8.0 5.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Nop53 PF07767.11 PIK62690.1 - 1.1e-65 222.5 37.6 6.1e-65 220.2 37.6 1.9 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF448 PF04296.13 PIK62690.1 - 0.72 9.8 4.4 0.71 9.8 1.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF448) Ribosomal_S5_C PF03719.15 PIK62691.1 - 2.3e-22 78.2 0.1 4.3e-22 77.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 PIK62691.1 - 6.7e-21 74.0 1.0 1.2e-20 73.3 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain ThiF PF00899.21 PIK62692.1 - 0.00053 19.4 0.0 0.00054 19.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family ThiF PF00899.21 PIK62693.1 - 4.9e-37 127.6 0.0 5.7e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 PIK62693.1 - 0.042 13.9 0.7 0.16 12.0 0.7 1.9 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Tyr_Deacylase PF02580.16 PIK62694.1 - 2.5e-51 174.0 0.0 3.6e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase PAH PF02671.21 PIK62694.1 - 0.0008 19.5 2.5 0.0054 16.8 0.3 2.7 2 0 0 2 2 2 1 Paired amphipathic helix repeat Ldh_1_C PF02866.18 PIK62695.1 - 4.6e-38 130.8 0.0 8.5e-38 129.9 0.0 1.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 PIK62695.1 - 3.5e-36 124.4 0.1 1.2e-35 122.7 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_3_C PF01915.22 PIK62695.1 - 0.049 13.6 0.0 0.8 9.6 0.0 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain ZU5 PF00791.20 PIK62696.1 - 9.8e-15 54.7 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 PIK62696.1 - 7.5e-09 35.6 0.3 1.4e-08 34.8 0.3 1.5 1 0 0 1 1 1 1 Death domain zf_C2H2_ZHX PF18387.1 PIK62697.1 - 0.0028 17.3 0.1 0.0076 15.9 0.1 1.8 1 0 0 1 1 1 1 Zinc-fingers and homeoboxes C2H2 finger domain DUF4695 PF15766.5 PIK62697.1 - 0.12 12.6 1.6 0.19 12.0 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4695) OATP PF03137.20 PIK62698.1 - 6.1e-61 206.4 1.1 7.1e-61 206.1 1.1 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK62698.1 - 1.1e-12 47.6 7.7 1.5e-12 47.1 7.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Citrus_P18 PF05520.11 PIK62698.1 - 0.31 10.8 2.5 0.2 11.4 0.2 1.8 2 0 0 2 2 2 0 Citrus tristeza virus P18 protein FtsX PF02687.21 PIK62698.1 - 1.4 9.5 13.3 3.3 8.3 1.3 2.7 2 0 0 2 2 2 0 FtsX-like permease family OATP PF03137.20 PIK62699.1 - 1.7e-70 237.9 3.8 1.2e-55 188.9 0.4 2.1 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 PIK62699.1 - 3.1e-11 42.8 10.8 6.1e-11 41.8 10.8 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Kazal_2 PF07648.15 PIK62699.1 - 9e-08 32.1 8.8 9e-08 32.1 8.8 1.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 PIK62699.1 - 0.0001 22.2 9.4 0.00024 21.0 9.4 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.7 PIK62699.1 - 0.011 14.6 1.1 0.026 13.4 0.2 1.7 1 1 0 2 2 2 0 MFS_1 like family TauE PF01925.19 PIK62699.1 - 4.4 6.9 14.1 26 4.3 14.1 2.2 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Prenyltrans PF00432.21 PIK62700.1 - 4.7e-44 147.8 14.5 7.6e-10 38.4 1.2 5.4 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 PIK62700.1 - 0.00012 21.3 0.0 3.5 6.6 0.0 3.1 2 1 0 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 PIK62700.1 - 0.00019 20.6 0.0 0.091 11.8 0.0 2.8 1 1 1 2 2 2 2 Squalene-hopene cyclase N-terminal domain CiPC PF15800.5 PIK62701.1 - 4.6e-11 43.0 16.1 5.8e-11 42.7 16.1 1.3 1 0 0 1 1 1 1 Clock interacting protein circadian IPP-2 PF04979.14 PIK62701.1 - 0.0066 17.2 3.1 0.0066 17.2 3.1 2.6 1 1 2 3 3 3 1 Protein phosphatase inhibitor 2 (IPP-2) Mob_synth_C PF06463.13 PIK62702.1 - 4.1e-37 127.0 0.0 6.1e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 PIK62702.1 - 1e-31 110.6 0.1 1.4e-31 110.1 0.1 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 PIK62702.1 - 4.6e-09 36.7 0.1 1.3e-08 35.2 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 PIK62702.1 - 9.3e-06 25.8 0.0 2.4e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Ad_cyc_g-alpha PF08509.11 PIK62702.1 - 1.2 8.9 5.6 73 3.2 0.1 3.9 4 0 0 4 4 4 0 Adenylate cyclase G-alpha binding domain MoaC PF01967.21 PIK62703.1 - 1.4e-37 128.9 0.7 1.6e-37 128.6 0.7 1.1 1 0 0 1 1 1 1 MoaC family DNA_pol3_beta PF00712.19 PIK62703.1 - 0.027 14.6 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain Ank_2 PF12796.7 PIK62705.1 - 1.6e-20 73.5 15.9 3.5e-09 37.1 0.3 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 PIK62705.1 - 3.1e-20 71.7 10.8 0.00098 19.5 0.1 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 PIK62705.1 - 7.9e-17 61.1 7.6 6.9e-06 26.2 0.2 5.3 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 PIK62705.1 - 3.2e-16 59.5 7.6 4.8e-05 23.8 0.1 5.6 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK62705.1 - 4.4e-12 45.1 10.4 0.084 13.5 0.0 6.1 6 0 0 6 6 6 5 Ankyrin repeat Pkinase PF00069.25 PIK62706.1 - 1.4e-59 201.7 0.0 2.5e-59 200.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62706.1 - 4.5e-32 111.3 0.0 1.1e-31 110.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 PIK62706.1 - 5.9e-19 67.6 0.0 1.2e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 PIK62706.1 - 1.5e-07 31.1 0.0 2.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 PIK62706.1 - 0.0007 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 RIO1 family UBA PF00627.31 PIK62706.1 - 0.0014 18.5 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Kdo PF06293.14 PIK62706.1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 PIK62706.1 - 0.028 13.4 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain M20_dimer PF07687.14 PIK62706.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Peptidase dimerisation domain Arm PF00514.23 PIK62707.1 - 5.8e-39 131.0 25.4 1.2e-06 28.4 0.2 11.1 12 0 0 12 12 12 7 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 PIK62707.1 - 2.7e-09 36.2 6.7 2.5e-07 29.6 2.5 3.4 3 1 0 3 3 3 1 Adaptin N terminal region KAP PF05804.12 PIK62707.1 - 5.8e-07 28.1 5.8 0.045 11.9 3.4 3.9 2 1 0 4 4 4 2 Kinesin-associated protein (KAP) HEAT_2 PF13646.6 PIK62707.1 - 1.3e-06 28.7 3.4 0.0017 18.7 0.6 4.6 3 1 1 4 4 4 1 HEAT repeats Cnd1 PF12717.7 PIK62707.1 - 2.2e-06 27.8 3.5 0.0089 16.1 0.6 4.0 3 2 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 PIK62707.1 - 0.00017 22.0 5.7 2.8 8.5 0.0 5.2 4 1 1 5 5 5 2 HEAT-like repeat Atx10homo_assoc PF09759.9 PIK62707.1 - 0.00023 21.1 3.1 0.0083 16.1 0.5 4.0 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 PIK62707.1 - 0.002 18.3 5.7 6 7.4 0.0 5.8 6 0 0 6 6 6 1 HEAT repeat Pes-10 PF07149.11 PIK62707.1 - 0.0045 16.1 1.0 2 7.4 0.1 2.6 2 1 1 3 3 3 2 Pes-10 DUF3361 PF11841.8 PIK62707.1 - 0.0061 16.5 6.8 3.7 7.5 0.0 4.0 4 1 1 5 5 5 2 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 PIK62707.1 - 0.0099 16.0 3.2 9.3 6.4 0.0 4.2 3 1 2 5 5 5 1 V-ATPase subunit H RasGEF_N_2 PF14663.6 PIK62707.1 - 2.3 8.7 11.3 41 4.6 0.1 5.6 5 2 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain wnt PF00110.19 PIK62708.1 - 5.2e-116 387.5 14.2 5.9e-116 387.4 14.2 1.0 1 0 0 1 1 1 1 wnt family Acyl-CoA_dh_1 PF00441.24 PIK62709.1 - 6.8e-33 114.0 4.5 7.5e-33 113.9 4.5 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 PIK62709.1 - 2.8e-14 53.5 3.5 3.8e-14 53.1 3.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain APH PF01636.23 PIK62710.1 - 2.1e-44 152.2 0.0 3.1e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_M PF02770.19 PIK62710.1 - 1.8e-18 66.5 0.0 3.6e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 PIK62710.1 - 3.7e-13 50.1 0.0 6.3e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain EcKinase PF02958.20 PIK62710.1 - 2.3e-07 30.4 0.1 5.1e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 PIK62710.1 - 5.3e-05 22.9 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 PIK62710.1 - 0.0011 18.6 0.2 0.054 13.1 0.1 2.2 2 0 0 2 2 2 1 RIO1 family DUF1679 PF07914.11 PIK62710.1 - 0.045 12.6 0.0 0.07 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 PIK62710.1 - 0.1 12.0 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain DNA_ligase_A_M PF01068.21 PIK62711.1 - 1.4e-52 178.3 0.0 2.9e-52 177.3 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 PIK62711.1 - 5.7e-42 144.0 0.4 1.1e-41 143.1 0.4 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 PIK62711.1 - 6.9e-16 58.7 0.0 2.3e-15 57.0 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_IV PF11411.8 PIK62711.1 - 3.1e-15 56.0 2.3 4.7e-15 55.4 1.4 1.9 2 0 0 2 2 1 1 DNA ligase IV RNA_ligase PF09414.10 PIK62711.1 - 3.7e-11 43.6 0.0 9.3e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 RNA ligase BRCT_2 PF16589.5 PIK62711.1 - 2.4e-09 37.5 0.0 5.3e-06 26.8 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 PIK62711.1 - 1.9e-05 24.9 0.1 0.00015 22.0 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.19 PIK62711.1 - 5.1e-05 23.2 0.0 0.00069 19.5 0.0 2.5 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain LIG3_BRCT PF16759.5 PIK62711.1 - 0.0083 16.4 0.0 0.17 12.2 0.0 2.6 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain PaREP1 PF05942.11 PIK62711.1 - 0.036 14.0 0.1 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family DUF5113 PF17140.4 PIK62711.1 - 0.064 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) EF-hand_1 PF00036.32 PIK62711.1 - 0.13 11.8 0.0 0.63 9.7 0.0 2.2 2 0 0 2 2 2 0 EF hand Cas1_AcylT PF07779.12 PIK62712.1 - 1.3e-107 360.7 18.0 1.6e-107 360.4 18.0 1.0 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p Sid-5 PF17204.3 PIK62712.1 - 0.095 12.9 1.2 1.1 9.4 0.4 2.5 2 0 0 2 2 2 0 Sid-5 family TRIQK PF15168.6 PIK62712.1 - 4.1 7.4 5.9 4.2 7.3 0.6 3.1 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family WD40 PF00400.32 PIK62715.1 - 1.5e-54 180.7 31.1 1.2e-10 41.8 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 PIK62715.1 - 8.6e-31 106.1 5.3 2e-07 31.2 0.3 6.8 2 2 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 PIK62715.1 - 1.8e-12 47.6 0.9 2.6e-05 24.2 0.1 2.9 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 PIK62715.1 - 4.3e-06 26.3 0.0 0.067 12.5 0.0 3.5 4 1 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 PIK62715.1 - 3.4e-05 23.0 0.3 0.11 11.4 0.0 3.5 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 PIK62715.1 - 0.0018 17.4 0.1 0.071 12.2 0.1 2.1 1 1 0 2 2 2 1 Coatomer WD associated region IKI3 PF04762.12 PIK62715.1 - 0.0022 16.1 2.1 0.39 8.6 0.6 2.4 2 1 0 2 2 2 2 IKI3 family PD40 PF07676.12 PIK62715.1 - 0.0027 17.6 0.0 0.37 10.8 0.0 3.0 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 PIK62715.1 - 0.061 13.0 0.0 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Nup160 PF11715.8 PIK62715.1 - 0.072 11.7 1.8 14 4.2 0.0 4.1 3 2 1 5 5 5 0 Nucleoporin Nup120/160 LisH PF08513.11 PIK62716.1 - 4.7e-10 39.1 0.0 7.4e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 LisH Phage_antitermQ PF06530.12 PIK62717.1 - 0.018 15.0 0.3 0.048 13.6 0.3 1.8 1 1 1 2 2 2 0 Phage antitermination protein Q TFIIE_alpha PF02002.17 PIK62718.1 - 0.068 13.0 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 TFIIE alpha subunit Pecanex_C PF05041.15 PIK62719.1 - 1.7e-92 309.2 0.0 2.7e-92 308.5 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) rve PF00665.26 PIK62720.1 - 3.1e-23 82.2 0.0 4.9e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK62720.1 - 0.0015 18.2 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 PIK62720.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.17 PIK62721.1 - 2.3e-65 220.5 0.0 3.3e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62721.1 - 2.3e-59 201.0 0.0 3.9e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.28 PIK62721.1 - 4.9e-13 48.5 0.2 9.4e-13 47.6 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 PIK62721.1 - 7.6e-12 44.9 0.0 2e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 PIK62721.1 - 1.1e-09 37.9 0.1 2.5e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Pkinase_fungal PF17667.1 PIK62721.1 - 0.00036 19.4 4.2 0.0011 17.8 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 PIK62721.1 - 0.0059 16.8 0.1 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 ABC1 family Hydantoinase_A PF01968.18 PIK62721.1 - 0.035 13.4 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase DUF3552 PF12072.8 PIK62721.1 - 0.31 10.4 11.0 0.6 9.5 11.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.14 PIK62721.1 - 0.32 11.3 2.5 0.55 10.6 2.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Fer2_2 PF01799.20 PIK62723.1 - 1.1e-30 105.5 0.1 2.4e-30 104.4 0.1 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 PIK62723.1 - 2.2e-09 37.2 2.6 2.2e-09 37.2 2.6 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain zf_CCCH_4 PF18345.1 PIK62723.1 - 0.14 12.3 0.6 0.14 12.3 0.6 2.2 2 0 0 2 2 2 0 Zinc finger domain DHODB_Fe-S_bind PF10418.9 PIK62723.1 - 1.6 8.6 11.3 0.056 13.2 4.2 2.2 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Ald_Xan_dh_C2 PF02738.18 PIK62724.1 - 2e-186 620.7 0.0 2.6e-186 620.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 PIK62724.1 - 4.7e-35 120.8 0.0 8.2e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 PIK62724.1 - 1.5e-25 89.7 2.1 1.7e-24 86.3 2.1 2.4 1 1 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 PIK62724.1 - 2.1e-17 63.2 0.0 1e-12 48.1 0.0 2.8 2 0 0 2 2 2 2 CO dehydrogenase flavoprotein C-terminal domain CLASP_N PF12348.8 PIK62725.1 - 5.3e-16 58.9 4.3 9.2e-09 35.2 0.3 3.2 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 PIK62725.1 - 1.4e-05 25.0 0.6 4.2 7.9 0.0 5.4 6 0 0 6 6 6 2 HEAT repeat NUC173 PF08161.12 PIK62725.1 - 0.03 14.0 0.6 32 4.1 0.0 3.9 3 1 1 4 4 4 0 NUC173 domain Dopey_N PF04118.14 PIK62725.1 - 0.033 13.3 0.0 0.13 11.4 0.0 2.0 1 0 0 1 1 1 0 Dopey, N-terminal RTP1_C1 PF10363.9 PIK62725.1 - 0.059 13.5 0.3 12 6.1 0.1 3.4 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 PIK62725.1 - 0.087 13.4 1.2 5.3 7.7 0.0 3.7 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region CAP_N PF01213.19 PIK62726.1 - 0.045 13.2 0.4 0.079 12.4 0.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SAM_1 PF00536.30 PIK62726.1 - 0.15 12.5 0.6 1.2 9.6 0.3 2.5 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) VIR_N PF15912.5 PIK62726.1 - 0.19 11.3 1.0 0.3 10.6 1.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Dscam_C PF12355.8 PIK62726.1 - 0.21 12.6 0.6 0.34 11.9 0.6 1.3 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal SAM_2 PF07647.17 PIK62726.1 - 0.28 11.3 1.0 2.9 8.1 0.3 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Pinin_SDK_memA PF04696.13 PIK62727.1 - 1.2e-31 109.5 12.2 1.2e-31 109.5 12.2 4.1 2 2 2 4 4 4 1 pinin/SDK/memA/ protein conserved region Pinin_SDK_N PF04697.13 PIK62727.1 - 1.4e-13 51.6 7.5 1.4e-13 51.6 7.5 4.5 3 2 1 5 5 5 1 pinin/SDK conserved region NUSAP PF16006.5 PIK62728.1 - 7.5e-34 117.8 47.9 3.3e-22 79.6 11.2 4.3 1 1 3 4 4 4 3 Nucleolar and spindle-associated protein zf-MYND PF01753.18 PIK62729.1 - 1.2e-08 34.9 15.8 2.6e-08 33.8 15.8 1.6 1 0 0 1 1 1 1 MYND finger PAS_3 PF08447.12 PIK62730.1 - 8.1e-21 74.1 0.1 3.7e-16 59.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 PIK62730.1 - 1.3e-18 67.1 0.2 5.3e-13 49.1 0.2 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 PIK62730.1 - 9.2e-15 54.6 0.0 1.7e-06 28.0 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 PIK62730.1 - 3.7e-10 40.0 0.0 1.7e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.26 PIK62730.1 - 0.0026 17.7 0.8 0.006 16.5 0.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.10 PIK62730.1 - 0.0063 16.7 0.0 4.2 7.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold KASH PF10541.9 PIK62731.1 - 0.00017 21.7 1.3 0.00034 20.8 1.3 1.5 1 0 0 1 1 1 1 Nuclear envelope localisation domain Spectrin PF00435.21 PIK62732.1 - 6.2e-19 68.4 21.4 2.2e-08 34.6 1.2 4.0 3 1 1 4 4 4 3 Spectrin repeat DUF2730 PF10805.8 PIK62732.1 - 0.06 13.4 2.3 0.4 10.8 0.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) TipAS PF07739.13 PIK62732.1 - 0.24 12.0 1.1 6 7.5 0.1 3.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain FAM76 PF16046.5 PIK62732.1 - 1.1 8.5 4.9 2.1 7.6 4.9 1.5 1 0 0 1 1 1 0 FAM76 protein DUF5082 PF16888.5 PIK62732.1 - 1.2 9.5 9.3 1.2 9.4 0.5 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Med9 PF07544.13 PIK62732.1 - 1.3 9.2 0.0 1.3 9.2 0.0 4.0 3 2 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.12 PIK62732.1 - 6.3 6.9 10.8 4.1 7.5 0.1 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) RRM_1 PF00076.22 PIK62733.1 - 2.3e-19 69.0 0.0 3e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 PIK62733.1 - 9e-05 22.1 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 PIK62733.1 - 0.00056 19.7 0.0 0.00079 19.2 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif SET_assoc PF11767.8 PIK62733.1 - 0.021 14.5 0.0 0.04 13.5 0.0 1.5 1 1 0 1 1 1 0 Histone lysine methyltransferase SET associated Limkain-b1 PF11608.8 PIK62733.1 - 0.022 14.8 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Limkain b1 RRM_7 PF16367.5 PIK62733.1 - 0.22 11.7 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif Cript PF10235.9 PIK62734.1 - 2e-25 89.2 0.5 2e-25 89.2 0.5 1.6 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT C1_2 PF03107.16 PIK62734.1 - 0.036 14.4 1.3 0.036 14.4 1.3 2.0 2 0 0 2 2 2 0 C1 domain DZR PF12773.7 PIK62734.1 - 0.73 9.9 7.8 4.9 7.2 7.8 2.1 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 PIK62734.1 - 1.1 9.4 9.0 3.8 7.7 5.2 2.1 1 1 1 2 2 2 0 FYVE zinc finger Ribosomal_L37e PF01907.19 PIK62734.1 - 1.5 9.0 10.1 0.35 11.1 5.5 2.1 2 0 0 2 2 2 0 Ribosomal protein L37e zf-C3HC4_3 PF13920.6 PIK62734.1 - 1.7 8.6 10.3 4.5 7.2 0.9 3.0 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TMEM107 PF14995.6 PIK62735.1 - 0.0055 17.1 0.9 1.8 9.0 0.0 2.4 2 0 0 2 2 2 2 Transmembrane protein DUF4418 PF14387.6 PIK62735.1 - 0.092 12.9 5.2 0.4 10.9 3.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4418) DHHC PF01529.20 PIK62735.1 - 0.37 10.9 4.3 0.31 11.1 1.2 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Yip1 PF04893.17 PIK62735.1 - 0.93 9.2 9.2 5.8 6.6 5.5 2.7 2 1 0 2 2 2 0 Yip1 domain DUF202 PF02656.15 PIK62735.1 - 4.5 7.8 8.4 9 6.8 0.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF202) zf-C3HC4_3 PF13920.6 PIK62737.1 - 2.4e-09 36.9 13.0 4.5e-09 36.0 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK62737.1 - 0.00063 19.6 12.6 0.0014 18.4 12.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Oxidored_q5_N PF01059.17 PIK62737.1 - 0.046 13.8 1.4 0.091 12.9 1.4 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus Ac76 PF05814.11 PIK62737.1 - 0.15 12.1 1.6 0.75 9.8 2.2 1.8 2 0 0 2 2 2 0 Orf76 (Ac76) DUF3149 PF11346.8 PIK62737.1 - 0.62 9.7 5.5 1.2 8.8 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Kinesin PF00225.23 PIK62738.1 - 1.2e-52 178.9 0.0 2.4e-52 177.9 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 PIK62738.1 - 1e-14 54.8 0.0 1.8e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding DUF1154 PF06631.11 PIK62739.1 - 2e-14 53.3 7.4 2e-14 53.3 7.4 4.0 5 0 0 5 5 5 1 Protein of unknown function (DUF1154) C2 PF00168.30 PIK62739.1 - 1.3e-06 28.6 0.0 3.3e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain PI-PLC-Y PF00387.19 PIK62740.1 - 0.00043 20.6 0.2 0.00067 20.0 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SAGA-Tad1 PF12767.7 PIK62740.1 - 0.067 12.9 0.0 0.079 12.7 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PI-PLC-X PF00388.19 PIK62741.1 - 6.5e-61 204.2 0.0 8.7e-61 203.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.11 PIK62741.1 - 2.6e-09 37.5 0.1 8.2e-09 35.8 0.1 1.9 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EBV-NA3 PF05009.12 PIK62741.1 - 0.2 11.2 0.1 0.31 10.6 0.1 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF3245 PF11595.8 PIK62741.1 - 0.23 11.9 0.9 0.37 11.3 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Cwf_Cwc_15 PF04889.12 PIK62741.1 - 0.48 10.1 4.1 0.74 9.5 4.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 PIK62741.1 - 1.3 9.5 9.1 3.9 7.9 9.2 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.8 PIK62741.1 - 2.4 8.3 7.0 3.8 7.7 7.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2457 PF10446.9 PIK62741.1 - 2.8 7.0 6.5 3.7 6.6 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PI-PLC-X PF00388.19 PIK62742.1 - 2.3e-58 195.9 0.4 2.6e-51 173.0 0.0 2.6 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 PIK62742.1 - 3.6e-41 140.1 0.0 8.7e-41 138.9 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_14 PF17787.1 PIK62742.1 - 1.8e-21 76.4 0.0 4e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 PH domain EF-hand_like PF09279.11 PIK62742.1 - 1.5e-06 28.6 0.0 4.7e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like adh_short PF00106.25 PIK62743.1 - 8.8e-34 116.7 0.0 6.8e-33 113.8 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 PIK62743.1 - 6.7e-24 84.7 0.0 2.6e-23 82.8 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 PIK62743.1 - 4e-09 36.6 0.0 6.2e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 PIK62743.1 - 0.00016 21.2 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Hpr_kinase_C PF07475.12 PIK62743.1 - 0.068 12.7 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Polysacc_synt_2 PF02719.15 PIK62743.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein CNH PF00780.22 PIK62744.1 - 7.2e-24 84.8 0.0 7.9e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 PIK62745.1 - 1.7e-25 89.9 0.0 2.7e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 PIK62745.1 - 4.2e-16 59.4 0.0 6.4e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 PIK62745.1 - 1.2e-15 57.5 0.0 2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L11_N PF03946.14 PIK62746.1 - 3.7e-23 81.1 0.4 5.6e-23 80.5 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 PIK62746.1 - 1.2e-18 67.4 0.3 2e-18 66.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Aldedh PF00171.22 PIK62747.1 - 2.8e-71 240.4 0.0 3.5e-71 240.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NAPRTase PF04095.16 PIK62748.1 - 5.3e-44 150.6 0.1 5.9e-43 147.2 0.1 2.1 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 PIK62748.1 - 2.5e-12 47.1 0.1 5.3e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5598) WRW PF10206.9 PIK62748.1 - 0.11 12.9 0.1 0.32 11.4 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f SmpA_OmlA PF04355.13 PIK62748.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 SmpA / OmlA family Proteasome PF00227.26 PIK62749.1 - 2e-57 193.8 0.0 2.7e-57 193.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 PIK62749.1 - 9.7e-14 50.7 0.0 1.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PI3K_P85_iSH2 PF16454.5 PIK62749.1 - 0.0012 18.5 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FIVAR PF07554.13 PIK62749.1 - 0.22 12.3 1.1 23 5.9 0.2 2.4 2 0 0 2 2 2 0 FIVAR domain Laps PF10169.9 PIK62750.1 - 1.7e-22 80.3 20.7 2.8e-10 40.9 10.1 2.3 1 1 1 2 2 2 2 Learning-associated protein DUF2423 PF10338.9 PIK62750.1 - 0.012 15.8 7.6 0.012 15.8 7.6 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2423) FAM176 PF14851.6 PIK62750.1 - 0.87 9.2 4.0 1.6 8.3 4.0 1.5 1 0 0 1 1 1 0 FAM176 family Actin PF00022.19 PIK62751.1 - 4.3e-15 55.2 0.0 1.3e-13 50.4 0.0 2.3 1 1 0 1 1 1 1 Actin Actin_micro PF17003.5 PIK62751.1 - 0.00027 20.2 0.0 0.00039 19.7 0.0 1.2 1 0 0 1 1 1 1 Putative actin-like family ODAPH PF15848.5 PIK62751.1 - 0.28 11.6 1.2 7.6 7.0 0.0 2.6 2 1 1 3 3 3 0 Odontogenesis associated phosphoprotein SelK_SelG PF10961.8 PIK62752.1 - 3.4e-23 82.0 0.5 4e-23 81.8 0.5 1.0 1 0 0 1 1 1 1 Selenoprotein SelK_SelG G-alpha PF00503.20 PIK62753.1 - 1.1e-96 324.1 1.1 1.3e-96 323.9 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 PIK62753.1 - 3.1e-13 49.6 0.3 6.6e-13 48.5 0.3 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family MITF_TFEB_C_3_N PF15951.5 PIK62754.1 - 8.9e-20 71.9 9.1 8.9e-20 71.9 9.1 3.2 4 0 0 4 4 4 1 MITF/TFEB/TFEC/TFE3 N-terminus HLH PF00010.26 PIK62754.1 - 2.4e-18 65.8 1.1 5.3e-18 64.7 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3371 PF11851.8 PIK62754.1 - 5.1e-07 30.8 6.3 5.1e-07 30.8 6.3 3.4 2 1 0 3 3 3 1 Domain of unknown function (DUF3371) IBR PF01485.21 PIK62755.1 - 6.1e-15 55.2 41.4 4.9e-09 36.3 6.5 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 PIK62755.1 - 8.4e-05 22.4 2.2 8.4e-05 22.4 2.2 4.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK62755.1 - 0.00022 21.5 5.8 0.00022 21.5 5.8 4.0 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 PIK62755.1 - 0.0013 18.6 3.3 0.0013 18.6 3.3 4.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 PIK62755.1 - 0.0014 18.6 2.5 0.0014 18.6 2.5 3.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK62755.1 - 0.0052 16.7 4.7 0.0052 16.7 4.7 3.5 3 0 0 3 3 3 1 zinc-RING finger domain DIM1 PF02966.16 PIK62759.1 - 3.6e-54 182.1 0.9 4.1e-54 181.9 0.9 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 PIK62759.1 - 8.7e-06 25.7 0.0 1.1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin RRM_1 PF00076.22 PIK62760.1 - 2.9e-19 68.7 0.2 4.6e-19 68.0 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 PIK62760.1 - 1e-05 25.3 3.0 1.7e-05 24.6 3.0 1.4 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 PIK62760.1 - 0.00012 21.7 0.0 0.00024 20.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 PIK62760.1 - 0.0019 18.4 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 RRM-like domain RRM_occluded PF16842.5 PIK62760.1 - 0.0054 16.6 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCHC_3 PF13917.6 PIK62760.1 - 0.0088 16.0 2.0 0.017 15.1 2.0 1.4 1 0 0 1 1 1 1 Zinc knuckle Limkain-b1 PF11608.8 PIK62760.1 - 0.0092 16.0 0.1 0.024 14.7 0.1 1.7 1 1 0 1 1 1 1 Limkain b1 RNA_bind PF08675.11 PIK62760.1 - 0.093 12.8 0.1 0.21 11.6 0.1 1.6 1 1 0 1 1 1 0 RNA binding domain zf-CCHC_6 PF15288.6 PIK62760.1 - 0.24 11.3 2.9 0.44 10.4 2.9 1.5 1 0 0 1 1 1 0 Zinc knuckle ECH_1 PF00378.20 PIK62761.1 - 4e-63 213.1 0.0 4.5e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 PIK62761.1 - 1.5e-30 106.9 0.1 2.6e-30 106.0 0.1 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Neur_chan_LBD PF02931.23 PIK62763.1 - 2.4e-20 72.9 0.1 3.4e-20 72.4 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK62763.1 - 0.047 13.7 0.6 0.072 13.1 0.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_S12 PF17487.2 PIK62763.1 - 0.098 13.4 1.0 0.098 13.4 1.0 2.3 1 1 1 2 2 2 0 Ribosomal protein S12 PI-PLC-Y PF00387.19 PIK62764.1 - 1.2e-38 132.0 0.7 3.1e-38 130.7 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain SH2 PF00017.24 PIK62764.1 - 6e-36 122.4 4.1 7.6e-19 67.6 0.3 2.9 2 1 0 2 2 2 2 SH2 domain C2 PF00168.30 PIK62764.1 - 6.9e-17 61.6 0.0 1.7e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.28 PIK62764.1 - 1.2e-11 44.0 2.1 1.3e-11 43.9 0.5 2.0 2 0 0 2 2 2 1 SH3 domain PH PF00169.29 PIK62764.1 - 5.4e-10 39.7 1.8 1.5e-06 28.6 0.0 3.4 3 1 0 3 3 3 2 PH domain SH3_9 PF14604.6 PIK62764.1 - 3.5e-08 33.2 1.3 9.2e-08 31.8 0.1 2.4 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 PIK62764.1 - 1.8e-05 24.3 0.0 4.4e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PI-PLC-X PF00388.19 PIK62765.1 - 2.6e-60 202.2 0.0 5.9e-60 201.1 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 PIK62765.1 - 1.3e-40 138.3 1.2 2.3e-40 137.5 0.1 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain SH2 PF00017.24 PIK62765.1 - 2.6e-37 126.8 2.5 1.1e-19 70.3 0.3 2.6 2 0 0 2 2 2 2 SH2 domain C2 PF00168.30 PIK62765.1 - 7.4e-17 61.5 0.0 1.5e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.28 PIK62765.1 - 6.8e-10 38.4 0.0 1.7e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 PIK62765.1 - 2.5e-07 31.1 0.2 0.001 19.6 0.0 3.6 3 0 0 3 3 3 1 PH domain SH3_9 PF14604.6 PIK62765.1 - 1.9e-06 27.6 0.0 1.9e-05 24.4 0.0 2.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 PIK62765.1 - 0.0001 21.9 0.0 0.00028 20.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_like PF09279.11 PIK62765.1 - 0.00022 21.6 0.5 0.00022 21.6 0.5 3.1 3 1 1 4 4 3 1 Phosphoinositide-specific phospholipase C, efhand-like LAGLIDADG_1 PF00961.19 PIK62765.1 - 0.014 16.4 0.5 13 6.8 0.0 3.3 3 0 0 3 3 2 0 LAGLIDADG endonuclease PH_12 PF16457.5 PIK62765.1 - 0.1 13.1 0.0 0.3 11.6 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain TMEM70 PF06979.12 PIK62766.1 - 2.7e-17 63.4 0.5 4.5e-17 62.7 0.5 1.3 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Rota_VP2 PF05087.12 PIK62766.1 - 0.048 11.8 0.1 0.057 11.6 0.1 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein ADK_lid PF05191.14 PIK62766.1 - 0.12 12.4 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid Syja_N PF02383.18 PIK62767.1 - 5.2e-52 177.2 2.0 4.4e-29 101.8 0.4 2.2 1 1 1 2 2 2 2 SacI homology domain PARP PF00644.20 PIK62768.1 - 2.5e-66 223.0 0.0 5.9e-66 221.8 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 PIK62768.1 - 7.5e-48 162.1 0.2 1.4e-47 161.2 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 PIK62768.1 - 3.3e-23 81.6 2.8 3.3e-23 81.6 2.8 2.0 2 0 0 2 2 2 1 WGR domain WWE PF02825.20 PIK62768.1 - 6.9e-10 39.4 0.9 2.2e-09 37.8 0.1 2.3 2 0 0 2 2 2 1 WWE domain ST7 PF04184.12 PIK62769.1 - 1e-255 849.3 8.6 2.2e-181 604.0 2.8 2.0 1 1 1 2 2 2 2 ST7 protein TPR_6 PF13174.6 PIK62769.1 - 0.00036 21.0 0.0 0.0012 19.3 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 PIK62769.1 - 0.0068 17.1 0.1 0.25 12.2 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.20 PIK62769.1 - 0.077 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.6 PIK62769.1 - 0.088 13.3 0.5 1.2 9.6 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4227 PF14004.6 PIK62769.1 - 0.13 12.3 0.2 0.37 10.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) TPR_2 PF07719.17 PIK62769.1 - 0.13 12.4 0.0 1.9 8.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RVT_1 PF00078.27 PIK62770.1 - 8.1e-05 22.2 0.1 0.0001 21.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sulfotransfer_1 PF00685.27 PIK62771.1 - 8.1e-08 32.1 0.4 6.2e-06 25.9 0.2 2.2 1 1 1 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK62771.1 - 0.00035 21.0 0.0 0.011 16.2 0.0 2.2 2 0 0 2 2 2 1 Sulfotransferase family cobW PF02492.19 PIK62771.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Rotamase_3 PF13616.6 PIK62774.1 - 0.12 12.9 8.0 0.53 10.8 7.9 2.2 1 1 0 1 1 1 0 PPIC-type PPIASE domain DUF812 PF05667.11 PIK62774.1 - 0.15 10.9 29.9 0.17 10.7 29.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FliT PF05400.13 PIK62774.1 - 0.41 11.5 17.4 2.2 9.2 8.4 2.6 2 0 0 2 2 2 0 Flagellar protein FliT FliJ PF02050.16 PIK62774.1 - 0.98 9.7 29.3 0.19 12.0 14.3 3.1 2 1 1 3 3 3 0 Flagellar FliJ protein IFT57 PF10498.9 PIK62774.1 - 1.8 7.4 27.0 0.94 8.4 5.4 2.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 CorA PF01544.18 PIK62774.1 - 3 7.1 11.3 14 4.9 11.3 2.1 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein KfrA_N PF11740.8 PIK62774.1 - 3.3 8.4 14.6 4 8.2 7.6 2.4 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term DUF948 PF06103.11 PIK62774.1 - 5 7.5 10.0 2 8.7 2.8 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) UBN_AB PF14075.6 PIK62774.1 - 5.1 6.8 21.3 0.44 10.2 16.7 1.5 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Fib_alpha PF08702.10 PIK62774.1 - 6 7.1 28.5 0.45 10.7 8.5 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family HisKA_3 PF07730.13 PIK62774.1 - 6.1 7.4 11.1 25 5.5 1.7 3.6 2 2 1 3 3 3 0 Histidine kinase HIP1_clath_bdg PF16515.5 PIK62774.1 - 6.6 7.4 35.7 0.3 11.7 19.1 2.7 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_MLP1_2 PF07926.12 PIK62774.1 - 6.9 6.7 35.2 4 7.5 25.4 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ING PF12998.7 PIK62774.1 - 7.4 7.2 22.4 1 10.0 3.8 2.9 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Sulfotransfer_2 PF03567.14 PIK62775.1 - 6.3e-07 29.6 0.0 1.2e-06 28.6 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family HECT PF00632.25 PIK62776.1 - 1.3e-54 185.8 0.1 1.5e-54 185.6 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 PIK62778.1 - 3.4e-27 93.0 25.5 2.4e-11 42.7 2.9 4.7 4 1 1 5 5 5 4 Ubiquitin binding region Afaf PF15339.6 PIK62778.1 - 0.32 10.7 5.2 45 3.7 0.0 3.6 3 0 0 3 3 3 0 Acrosome formation-associated factor ATP-synt_B PF00430.18 PIK62778.1 - 0.59 10.2 11.6 2.8 8.0 11.6 2.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Borrelia_P83 PF05262.11 PIK62778.1 - 8.9 4.7 11.8 22 3.4 11.8 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF913 PF06025.12 PIK62780.1 - 1.9e-111 372.6 1.3 1.3e-110 369.9 0.0 3.0 4 0 0 4 4 4 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 PIK62780.1 - 1.4e-25 90.5 20.8 2.1e-24 86.6 10.8 3.9 3 1 0 3 3 3 1 Domain of Unknown Function (DUF908) WWE PF02825.20 PIK62780.1 - 1.3e-13 51.3 1.5 3.4e-13 50.0 1.5 1.7 1 0 0 1 1 1 1 WWE domain UBA PF00627.31 PIK62780.1 - 2.2e-05 24.2 0.0 5.8e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain LRR_4 PF12799.7 PIK62781.1 - 3e-11 43.3 13.0 0.00011 22.6 0.2 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 PIK62781.1 - 6.6e-11 41.8 21.0 1.9e-05 24.3 3.2 3.8 3 1 1 4 4 4 3 Leucine rich repeat I-set PF07679.16 PIK62781.1 - 2.8e-05 24.1 0.0 5.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK62781.1 - 9.9e-05 22.9 0.2 0.00073 20.1 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain LRR_1 PF00560.33 PIK62781.1 - 0.00037 20.6 13.4 0.79 10.5 0.1 5.6 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 PIK62781.1 - 0.00071 19.4 14.5 15 5.9 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich repeat LRRNT PF01462.18 PIK62781.1 - 0.43 10.3 2.2 0.75 9.5 0.2 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain PET PF06297.14 PIK62782.1 - 2.1e-31 108.1 0.4 3.2e-31 107.5 0.4 1.3 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 PIK62782.1 - 9.5e-10 38.6 5.6 9.5e-10 38.6 5.6 3.4 3 2 1 4 4 4 1 LIM domain VATC PF18716.1 PIK62782.1 - 0.042 13.7 1.2 0.042 13.7 1.2 3.3 3 2 1 4 4 4 0 Vms1-associating treble clef domain Tctex-1 PF03645.13 PIK62783.1 - 1.8e-23 82.7 0.4 2.3e-23 82.4 0.4 1.1 1 0 0 1 1 1 1 Tctex-1 family tRNA-Thr_ED PF08915.11 PIK62783.1 - 0.061 13.4 0.2 0.071 13.2 0.2 1.2 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase 7tm_1 PF00001.21 PIK62784.1 - 2.5e-39 135.2 22.4 2.5e-39 135.2 22.4 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK62784.1 - 2e-06 27.7 21.2 2e-06 27.7 21.2 2.4 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK62784.1 - 6.4e-05 22.8 13.8 0.0003 20.6 13.8 1.9 1 1 0 1 1 1 1 Olfactory receptor COesterase PF00135.28 PIK62786.1 - 9.2e-39 133.7 0.0 1.1e-38 133.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 PIK62786.1 - 0.0017 18.3 0.4 0.0022 17.9 0.4 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold FTZ PF03867.14 PIK62786.1 - 0.15 11.5 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region COesterase PF00135.28 PIK62787.1 - 3.1e-33 115.4 0.0 4.3e-33 115.0 0.0 1.2 1 1 0 1 1 1 1 Carboxylesterase family WD40 PF00400.32 PIK62788.1 - 3.6e-12 46.6 12.6 2.5e-06 28.1 0.2 6.6 7 0 0 7 7 5 2 WD domain, G-beta repeat NACHT PF05729.12 PIK62788.1 - 1.7e-09 37.8 0.0 3.3e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 PIK62788.1 - 5.5e-09 36.2 0.5 0.038 14.3 0.1 4.7 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 PIK62788.1 - 4.2e-05 24.0 0.0 0.00033 21.1 0.0 2.5 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 PIK62788.1 - 0.00052 20.3 0.0 0.0022 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain Nup160 PF11715.8 PIK62788.1 - 0.00065 18.5 0.3 0.33 9.5 0.1 2.7 3 0 0 3 3 3 2 Nucleoporin Nup120/160 ATPase_2 PF01637.18 PIK62788.1 - 0.00067 19.6 0.0 0.002 18.1 0.0 1.8 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF533 PF04391.12 PIK62788.1 - 0.0063 16.1 0.1 0.021 14.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF533) WD40_like PF17005.5 PIK62788.1 - 0.011 15.1 1.0 3.5 6.9 0.0 3.3 3 1 0 3 3 3 0 WD40-like domain NB-ARC PF00931.22 PIK62788.1 - 0.016 14.4 0.0 0.039 13.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 PIK62788.1 - 0.019 14.7 0.0 0.058 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK62788.1 - 0.02 14.4 0.1 0.045 13.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 PIK62788.1 - 0.026 14.2 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 PIK62788.1 - 0.036 13.8 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytochrom_D1 PF02239.16 PIK62788.1 - 0.087 11.3 0.2 1.9 6.9 0.2 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain ResIII PF04851.15 PIK62788.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 PIK62788.1 - 0.11 12.9 0.0 0.31 11.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 PIK62788.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA PF00004.29 PIK62788.1 - 0.15 12.5 0.0 0.43 11.0 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) VID27 PF08553.10 PIK62788.1 - 0.22 10.5 0.3 0.54 9.2 0.1 1.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain fn3 PF00041.21 PIK62789.1 - 1.2e-08 35.2 0.6 3.1e-05 24.2 0.0 3.0 3 0 0 3 3 3 2 Fibronectin type III domain Interfer-bind PF09294.10 PIK62789.1 - 0.00066 20.0 0.0 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 PIK62790.1 - 3.9e-20 72.0 0.1 0.0033 17.7 0.0 7.7 7 1 0 7 7 7 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 PIK62790.1 - 0.035 14.7 0.0 6.3 7.4 0.0 3.2 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Thioredoxin_2 PF13098.6 PIK62790.1 - 0.059 13.8 0.0 0.35 11.3 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_8 PF13905.6 PIK62790.1 - 0.095 13.0 0.1 21 5.5 0.0 2.9 2 0 0 2 2 2 0 Thioredoxin-like fn3_2 PF16893.5 PIK62790.1 - 0.12 12.5 0.0 0.99 9.6 0.0 2.4 2 0 0 2 2 2 0 Fibronectin type III domain Homeodomain PF00046.29 PIK62791.1 - 1.8e-21 75.7 0.2 3e-21 75.0 0.2 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 PIK62791.1 - 0.0029 17.5 0.1 0.0076 16.1 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Edc3_linker PF16598.5 PIK62791.1 - 0.024 15.3 0.2 0.081 13.6 0.2 1.9 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 Myc_N PF01056.18 PIK62791.1 - 0.038 13.9 1.3 0.066 13.1 1.3 1.3 1 0 0 1 1 1 0 Myc amino-terminal region TMEM154 PF15102.6 PIK62792.1 - 4.4e-05 23.4 0.7 4.4e-05 23.4 0.7 5.9 1 1 2 3 3 3 1 TMEM154 protein family Amnionless PF14828.6 PIK62792.1 - 0.0003 19.7 0.1 0.0006 18.8 0.1 1.5 1 0 0 1 1 1 1 Amnionless Orf78 PF06024.12 PIK62792.1 - 0.0069 16.7 1.5 0.024 14.9 0.0 2.6 2 1 1 3 3 3 1 Orf78 (ac78) Sigma_reg_N PF13800.6 PIK62792.1 - 0.038 14.3 0.2 0.25 11.6 0.2 2.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Cadherin_C_2 PF16492.5 PIK62792.1 - 0.1 13.4 0.0 0.1 13.4 0.0 3.3 3 1 0 3 3 3 0 Cadherin cytoplasmic C-terminal CrgA PF06781.12 PIK62792.1 - 0.15 12.2 0.0 0.53 10.4 0.0 2.0 1 0 0 1 1 1 0 Cell division protein CrgA Med20 PF08612.11 PIK62793.1 - 9.1e-35 120.0 0.1 1.1e-34 119.8 0.1 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Ribosomal_L2_C PF03947.18 PIK62794.1 - 1.5e-27 96.3 0.1 3.5e-27 95.1 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 PIK62794.1 - 3.5e-24 84.5 0.2 6.4e-24 83.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain G-patch_2 PF12656.7 PIK62796.1 - 3.2e-17 62.3 0.4 3.2e-17 62.3 0.4 2.7 2 0 0 2 2 2 1 G-patch domain KOW PF00467.29 PIK62796.1 - 6e-06 26.0 4.8 0.066 13.2 0.4 3.4 3 0 0 3 3 3 2 KOW motif KN17_SH3 PF18131.1 PIK62796.1 - 0.00046 20.2 0.1 0.0015 18.6 0.0 1.9 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain G-patch PF01585.23 PIK62796.1 - 0.0023 17.8 4.9 0.0092 15.9 4.9 2.1 1 1 0 1 1 1 1 G-patch domain WW PF00397.26 PIK62798.1 - 0.00017 21.6 1.6 0.0003 20.8 1.6 1.5 1 0 0 1 1 1 1 WW domain DUF5125 PF17163.4 PIK62799.1 - 0.022 14.9 0.1 0.39 10.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5125) EphA2_TM PF14575.6 PIK62799.1 - 0.11 13.4 0.0 0.54 11.2 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MCM_N PF14551.6 PIK62800.1 - 1.4e-21 77.0 1.4 2.3e-21 76.3 1.4 1.3 1 0 0 1 1 1 1 MCM N-terminal domain MCM PF00493.23 PIK62801.1 - 1e-99 332.2 0.0 1.5e-99 331.6 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 PIK62801.1 - 1.1e-27 96.2 0.1 2.9e-27 94.9 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 PIK62801.1 - 9.1e-22 77.2 0.1 1.9e-21 76.2 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 PIK62801.1 - 1.2e-06 28.1 0.0 0.00047 19.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 PIK62801.1 - 2.1e-05 24.5 0.0 9.2e-05 22.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 PIK62801.1 - 0.0044 16.9 0.1 0.013 15.3 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK62801.1 - 0.029 14.1 0.0 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Gal-3-0_sulfotr PF06990.11 PIK62802.1 - 8.1e-37 127.0 0.8 9.6e-37 126.8 0.8 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Fibrinogen_C PF00147.18 PIK62803.1 - 4.9e-50 170.4 2.3 1.5e-41 142.7 0.3 2.1 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62803.1 - 9.4e-09 35.1 7.8 9.4e-09 35.1 7.8 3.4 3 1 1 4 4 4 1 TILa domain TIL PF01826.17 PIK62803.1 - 3e-05 24.2 17.8 3e-05 24.2 17.8 3.9 3 1 1 4 4 4 1 Trypsin Inhibitor like cysteine rich domain EGF_3 PF12947.7 PIK62803.1 - 0.00026 21.1 10.8 0.00026 21.1 10.8 4.7 3 2 1 4 4 4 1 EGF domain RlmM_FDX PF18125.1 PIK62803.1 - 0.57 10.7 2.9 20 5.8 0.1 2.5 2 0 0 2 2 2 0 RlmM ferredoxin-like domain RVT_1 PF00078.27 PIK62804.1 - 8.2e-21 74.5 0.1 1.6e-20 73.6 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 PIK62804.1 - 0.00045 20.2 0.1 0.0013 18.8 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Fibrinogen_C PF00147.18 PIK62805.1 - 6.6e-40 137.3 0.1 8.7e-40 136.9 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62805.1 - 0.0011 18.9 6.8 0.0011 18.9 6.8 2.5 2 0 0 2 2 2 1 TILa domain EGF_3 PF12947.7 PIK62805.1 - 0.0053 16.9 2.9 0.0053 16.9 2.9 3.2 2 1 1 3 3 3 1 EGF domain RT_RNaseH_2 PF17919.1 PIK62806.1 - 1.7e-29 101.8 0.0 5.9e-29 100.0 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62806.1 - 6.4e-25 87.5 0.0 5.6e-24 84.5 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK62806.1 - 3.6e-19 68.6 1.4 6.8e-19 67.7 1.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 PIK62806.1 - 2.3e-17 63.3 0.1 6.6e-17 61.8 0.1 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 PIK62806.1 - 5.6e-06 26.5 0.2 1.5e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 PIK62806.1 - 0.0002 21.5 0.7 0.00051 20.2 0.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Fibrinogen_C PF00147.18 PIK62807.1 - 1.7e-82 276.5 10.0 1.4e-41 142.8 0.4 2.5 3 0 0 3 3 3 2 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62807.1 - 2.4e-08 33.8 7.5 2.4e-08 33.8 7.5 3.3 2 1 1 3 3 3 1 TILa domain EGF_3 PF12947.7 PIK62807.1 - 5.6e-05 23.3 7.9 5.6e-05 23.3 7.9 4.6 4 1 0 4 4 4 1 EGF domain EGF_MSP1_1 PF12946.7 PIK62807.1 - 5 7.3 22.2 0.19 11.8 6.6 3.5 3 0 0 3 3 3 0 MSP1 EGF domain 1 Fibrinogen_C PF00147.18 PIK62808.1 - 7.6e-41 140.3 2.5 1e-40 139.9 2.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62808.1 - 1.4e-07 31.3 7.0 3.9e-07 29.9 7.0 1.8 1 0 0 1 1 1 1 TILa domain EGF_3 PF12947.7 PIK62808.1 - 9e-05 22.6 10.3 9e-05 22.6 10.3 2.6 1 1 1 2 2 2 1 EGF domain EGF PF00008.27 PIK62808.1 - 0.043 14.1 4.4 0.043 14.1 4.4 2.3 2 0 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.7 PIK62808.1 - 0.41 10.7 14.6 0.06 13.4 6.6 2.4 2 0 0 2 2 2 0 MSP1 EGF domain 1 EGF_CA PF07645.15 PIK62808.1 - 1 9.7 18.0 21 5.4 17.9 2.7 1 1 0 1 1 1 0 Calcium-binding EGF domain Fibrinogen_C PF00147.18 PIK62809.1 - 2.4e-41 142.0 1.8 3.7e-41 141.4 1.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TILa PF12714.7 PIK62809.1 - 3.4e-05 23.7 4.9 9.4e-05 22.3 4.9 1.7 1 0 0 1 1 1 1 TILa domain EGF_3 PF12947.7 PIK62809.1 - 7.5e-05 22.8 2.9 7.5e-05 22.8 2.9 2.5 2 0 0 2 2 2 1 EGF domain cEGF PF12662.7 PIK62809.1 - 6.4 6.8 14.1 1.2 9.1 6.4 2.9 2 1 0 2 2 2 0 Complement Clr-like EGF-like RT_RNaseH_2 PF17919.1 PIK62810.1 - 9.9e-38 128.2 0.0 3.6e-37 126.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK62810.1 - 3.9e-35 120.3 0.0 1.5e-34 118.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 PIK62810.1 - 1.8e-20 73.3 0.0 3.5e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62810.1 - 2.8e-14 52.9 0.0 5.6e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 PIK62810.1 - 1e-05 26.0 0.0 2.5e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 PIK62810.1 - 5.8e-05 23.2 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 PIK62810.1 - 0.00012 22.7 0.0 0.00045 20.8 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.6 PIK62810.1 - 0.00019 21.2 0.0 0.00042 20.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DNA_pol_viral_C PF00336.18 PIK62810.1 - 0.033 13.6 0.0 0.084 12.3 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain RVP PF00077.20 PIK62810.1 - 0.08 13.3 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease Fibrinogen_C PF00147.18 PIK62811.1 - 5.4e-42 144.1 0.4 6.4e-42 143.8 0.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Resistin PF06954.11 PIK62811.1 - 1.3 9.6 15.1 2 9.0 5.9 2.9 2 1 1 3 3 3 0 Resistin Tme5_EGF_like PF09064.10 PIK62811.1 - 1.7 8.6 16.9 2.2 8.3 12.3 2.9 2 1 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Fibrinogen_C PF00147.18 PIK62812.1 - 1.1e-49 169.3 8.6 1.2e-49 169.1 8.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain GRAM PF02893.20 PIK62813.1 - 4.7e-10 39.4 0.0 1.3e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 GRAM domain DUF3292 PF11696.8 PIK62813.1 - 6.8e-07 28.1 0.3 6.8e-07 28.1 0.3 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3292) PRT_C PF08372.10 PIK62813.1 - 1.7e-06 27.9 2.3 6.1e-05 22.8 0.0 2.6 3 0 0 3 3 3 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 PIK62813.1 - 3.7e-06 26.5 1.0 0.0019 17.6 0.1 2.5 2 0 0 2 2 2 2 Plant protein of unknown function (DUF639) Vps36_ESCRT-II PF11605.8 PIK62813.1 - 0.016 15.4 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 DUF1493 PF07377.12 PIK62813.1 - 0.076 13.5 0.4 1.2 9.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) DUF2730 PF10805.8 PIK62813.1 - 0.3 11.2 3.2 2.4 8.3 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Thymosin PF01290.20 PIK62813.1 - 0.49 10.2 4.0 0.3 10.9 0.2 2.7 3 0 0 3 3 3 0 Thymosin beta-4 family DUF4600 PF15372.6 PIK62813.1 - 0.94 9.9 16.0 0.028 14.9 5.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF148 PF02520.17 PIK62813.1 - 1 9.5 8.3 0.19 11.8 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF148 Fungal_TACC PF12709.7 PIK62813.1 - 6.6 7.3 12.3 1.4 9.4 0.3 3.4 2 2 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Rad4 PF03835.15 PIK62814.1 - 9.3e-25 87.0 3.8 9.3e-25 87.0 3.8 3.0 4 0 0 4 4 4 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 PIK62814.1 - 1.9e-17 62.8 0.3 6.4e-17 61.1 0.1 2.1 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 PIK62814.1 - 1.6e-13 51.4 0.4 1.6e-13 51.4 0.4 3.3 4 0 0 4 4 4 1 Rad4 beta-hairpin domain 2 BHD_3 PF10405.9 PIK62814.1 - 3e-10 40.4 0.0 2.3e-09 37.5 0.0 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 Transglut_core PF01841.19 PIK62815.1 - 0.00099 19.5 0.4 0.0084 16.6 0.0 2.2 1 1 1 2 2 2 1 Transglutaminase-like superfamily DDHD PF02862.17 PIK62815.1 - 5.1 7.2 8.2 0.38 10.9 1.2 2.1 2 0 0 2 2 2 0 DDHD domain Neur_chan_memb PF02932.16 PIK62815.1 - 9.1 6.3 7.7 0.97 9.4 0.8 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LSM PF01423.22 PIK62817.1 - 8.9e-20 70.2 0.2 1.3e-19 69.6 0.2 1.3 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.18 PIK62817.1 - 0.091 12.2 0.2 0.12 11.7 0.2 1.3 1 1 0 1 1 1 0 ATP synthase (E/31 kDa) subunit HydF_dimer PF18128.1 PIK62817.1 - 0.15 12.2 0.1 0.28 11.3 0.1 1.6 1 1 0 1 1 1 0 Hydrogen maturase F dimerization domain Dus PF01207.17 PIK62818.1 - 3.8e-67 226.6 0.1 4.6e-67 226.3 0.1 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 PIK62818.1 - 0.00027 20.5 0.0 0.00056 19.4 0.0 1.4 1 1 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 PIK62818.1 - 0.0011 18.4 0.1 0.0014 17.9 0.1 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase SOR_SNZ PF01680.17 PIK62818.1 - 0.036 13.8 0.5 0.1 12.4 0.4 1.7 1 1 1 2 2 2 0 SOR/SNZ family Septin PF00735.18 PIK62818.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_18 PF13238.6 PIK62819.1 - 2.2e-06 28.2 0.1 5.8e-05 23.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 PIK62819.1 - 4.9e-05 23.6 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 PIK62819.1 - 7.7e-05 23.1 0.0 0.00036 21.0 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 PIK62819.1 - 0.00019 21.2 0.0 0.00064 19.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 PIK62819.1 - 0.00026 21.3 0.0 0.0011 19.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 PIK62819.1 - 0.00033 21.1 0.0 0.00096 19.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 PIK62819.1 - 0.00082 19.4 0.0 0.0026 17.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 PIK62819.1 - 0.0019 17.9 0.0 0.0063 16.2 0.0 1.8 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain CbiA PF01656.23 PIK62819.1 - 0.0032 17.5 0.0 0.013 15.6 0.0 2.0 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 PIK62819.1 - 0.0036 17.3 0.0 0.0092 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF87 PF01935.17 PIK62819.1 - 0.0053 16.9 0.0 0.02 15.0 0.0 2.0 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_31 PF13614.6 PIK62819.1 - 0.0063 16.5 0.1 0.048 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 PIK62819.1 - 0.0078 16.1 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 PIK62819.1 - 0.0084 15.9 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 PIK62819.1 - 0.01 15.3 0.0 0.026 14.0 0.0 1.7 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_19 PF13245.6 PIK62819.1 - 0.01 16.2 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 PIK62819.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 PIK62819.1 - 0.021 14.4 0.0 0.051 13.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 PIK62819.1 - 0.027 14.5 0.0 0.091 12.8 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 PIK62819.1 - 0.028 14.2 0.0 0.086 12.6 0.0 1.9 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase OST-HTH PF12872.7 PIK62819.1 - 0.029 14.2 0.0 2.9 7.8 0.0 2.9 2 0 0 2 2 2 0 OST-HTH/LOTUS domain AAA_33 PF13671.6 PIK62819.1 - 0.04 14.1 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK62819.1 - 0.058 13.9 0.0 0.21 12.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 PIK62819.1 - 0.074 12.9 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 PIK62819.1 - 0.1 12.8 0.0 0.31 11.2 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_17 PF13207.6 PIK62819.1 - 0.1 13.0 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 PIK62819.1 - 0.2 11.2 0.0 0.92 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain OCRE PF17780.1 PIK62820.1 - 5e-17 61.7 17.9 5e-17 61.7 17.9 2.4 2 0 0 2 2 2 1 OCRE domain G-patch PF01585.23 PIK62820.1 - 1.8e-13 50.1 6.8 4.3e-13 48.9 6.8 1.7 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 PIK62820.1 - 1.5e-11 43.9 0.0 7.6e-09 35.3 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 PIK62820.1 - 5e-10 39.3 2.0 2.1e-09 37.4 2.0 2.2 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 PIK62820.1 - 4.1e-05 22.8 1.3 7.4e-05 22.0 1.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-C2H2_11 PF16622.5 PIK62820.1 - 0.034 13.9 0.3 0.034 13.9 0.3 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 PIK62820.1 - 0.035 14.4 0.2 0.094 13.0 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK62820.1 - 0.08 13.4 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DZR PF12773.7 PIK62820.1 - 0.36 10.9 2.4 0.51 10.4 0.9 1.9 2 0 0 2 2 2 0 Double zinc ribbon zf-CpG_bind_C PF12269.8 PIK62821.1 - 1.8e-95 319.2 11.5 1.8e-95 319.2 11.5 4.0 4 0 0 4 4 4 1 CpG binding protein zinc finger C terminal domain zf-CXXC PF02008.20 PIK62821.1 - 5.3e-15 55.2 18.3 5.3e-15 55.2 18.3 3.2 3 0 0 3 3 3 1 CXXC zinc finger domain PHD PF00628.29 PIK62821.1 - 3.1e-09 36.6 10.0 3.1e-09 36.6 10.0 4.0 4 0 0 4 4 4 1 PHD-finger DUF2116 PF09889.9 PIK62821.1 - 0.18 11.8 3.8 9.7 6.3 0.3 3.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) BORCS6 PF10157.9 PIK62822.1 - 1.9e-49 167.8 3.1 3.8e-49 166.8 3.1 1.5 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 BLOC1_2 PF10046.9 PIK62822.1 - 0.011 16.0 0.3 0.024 14.9 0.3 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Macoilin PF09726.9 PIK62822.1 - 0.88 8.1 11.8 0.24 9.9 1.1 2.0 2 0 0 2 2 2 0 Macoilin family Kelch_3 PF13415.6 PIK62823.1 - 1.8e-24 85.5 2.3 0.00023 21.4 0.0 6.4 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 PIK62823.1 - 1.5e-22 79.1 3.3 0.00032 20.6 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 PIK62823.1 - 2e-16 59.7 0.4 0.024 14.6 0.0 6.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 PIK62823.1 - 4e-16 58.6 3.7 0.0059 16.8 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 PIK62823.1 - 1.9e-13 49.8 0.9 9.6e-05 21.9 0.0 5.5 5 0 0 5 5 5 3 Kelch motif fn3 PF00041.21 PIK62823.1 - 3.3e-12 46.6 0.2 0.0029 17.9 0.0 4.4 4 0 0 4 4 4 3 Fibronectin type III domain Kelch_2 PF07646.15 PIK62823.1 - 3.6e-10 39.4 1.1 0.011 15.7 0.0 5.8 6 0 0 6 6 6 2 Kelch motif LRAT PF04970.13 PIK62824.1 - 4.7e-07 30.1 1.4 2.5e-06 27.8 1.4 2.1 1 1 0 1 1 1 1 Lecithin retinol acyltransferase SLAC1 PF03595.17 PIK62824.1 - 0.057 12.7 1.1 0.09 12.0 1.1 1.2 1 0 0 1 1 1 0 Voltage-dependent anion channel Orf78 PF06024.12 PIK62824.1 - 0.11 12.7 1.6 0.23 11.8 1.6 1.5 1 0 0 1 1 1 0 Orf78 (ac78) RdRP_4 PF02123.16 PIK62824.1 - 0.12 11.2 0.1 0.17 10.7 0.1 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase DUF2569 PF10754.9 PIK62824.1 - 0.55 10.7 6.0 1 9.8 5.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) Spo7 PF03907.13 PIK62824.1 - 0.74 9.3 3.5 0.96 8.9 0.7 2.1 1 1 1 2 2 2 0 Spo7-like protein Sigma_reg_N PF13800.6 PIK62824.1 - 2.9 8.2 6.9 0.24 11.7 0.5 2.4 2 1 1 3 3 3 0 Sigma factor regulator N-terminal FtsX PF02687.21 PIK62824.1 - 3 8.4 6.7 9.2 6.8 0.1 2.6 3 0 0 3 3 3 0 FtsX-like permease family Ac81 PF05820.11 PIK62824.1 - 8.3 5.9 12.0 0.091 12.3 4.3 1.7 2 0 0 2 2 2 0 Baculoviridae AC81 Somatomedin_B PF01033.17 PIK62825.1 - 3.4 8.2 14.7 0.26 11.7 8.6 2.4 2 0 0 2 2 2 0 Somatomedin B domain 7tm_2 PF00002.24 PIK62826.1 - 9.1e-14 51.3 15.5 9.5e-14 51.3 8.1 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) FA_desaturase PF00487.24 PIK62826.1 - 0.043 13.7 5.1 0.05 13.4 1.0 2.1 2 0 0 2 2 2 0 Fatty acid desaturase Plexin_cytopl PF08337.12 PIK62827.1 - 3.9e-164 547.4 0.6 5.2e-164 547.0 0.6 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 PIK62827.1 - 5e-31 108.0 1.5 5e-31 108.0 1.5 2.2 2 1 0 2 2 2 1 Sema domain TIG PF01833.24 PIK62827.1 - 5.1e-29 100.2 6.3 4.6e-08 33.0 0.1 5.7 5 0 0 5 5 5 5 IPT/TIG domain TIG_plexin PF17960.1 PIK62827.1 - 8.8e-17 60.9 0.5 3.2e-15 55.9 0.1 3.1 2 0 0 2 2 2 1 TIG domain PSI PF01437.25 PIK62827.1 - 3.3e-12 46.7 50.8 0.00015 22.2 10.0 3.6 3 0 0 3 3 3 3 Plexin repeat TIG_2 PF18020.1 PIK62827.1 - 3.7e-11 43.5 0.1 3.7e-08 33.9 0.0 3.0 2 0 0 2 2 2 2 TIG domain found in plexin FixQ PF05545.11 PIK62827.1 - 0.0043 17.0 0.0 0.22 11.5 0.0 2.4 2 0 0 2 2 2 1 Cbb3-type cytochrome oxidase component FixQ Vpu PF00558.19 PIK62827.1 - 0.57 10.0 2.6 1.4 8.8 2.6 1.6 1 0 0 1 1 1 0 Vpu protein CD34_antigen PF06365.12 PIK62827.1 - 0.65 9.5 3.2 4.5 6.8 0.7 2.5 2 0 0 2 2 2 0 CD34/Podocalyxin family DUF5582 PF17819.1 PIK62828.1 - 3.9e-06 27.4 0.2 7.8e-06 26.4 0.1 1.5 2 0 0 2 2 2 1 Family of unknown function (DUF5582) DUF5586 PF17824.1 PIK62828.1 - 0.002 17.3 0.0 0.0026 16.9 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5586) EF-hand_1 PF00036.32 PIK62828.1 - 0.0037 16.7 0.1 0.018 14.6 0.0 2.1 2 0 0 2 2 2 1 EF hand Dpy-30 PF05186.13 PIK62828.1 - 0.0063 16.2 0.1 0.011 15.4 0.1 1.4 1 1 0 1 1 1 1 Dpy-30 motif RIIa PF02197.17 PIK62828.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit EF-hand_6 PF13405.6 PIK62828.1 - 0.012 15.4 0.0 0.037 14.0 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 PIK62828.1 - 0.079 13.4 0.0 0.15 12.6 0.0 1.7 1 1 0 1 1 1 0 EF-hand domain pair MIF4G PF02854.19 PIK62829.1 - 4.1e-56 190.0 11.1 1.2e-38 132.9 0.0 4.9 3 1 1 4 4 4 4 MIF4G domain Upf2 PF04050.14 PIK62829.1 - 3.3e-30 105.6 8.4 3.3e-30 105.6 8.4 4.8 3 1 0 3 3 3 1 Up-frameshift suppressor 2 DUF2325 PF10087.9 PIK62829.1 - 0.071 13.2 0.6 0.32 11.1 0.6 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Gal-3-0_sulfotr PF06990.11 PIK62830.1 - 2.7e-24 85.8 0.7 3.3e-24 85.5 0.7 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 PIK62830.1 - 0.004 17.6 0.2 0.012 16.0 0.1 1.9 1 1 1 2 2 2 1 Sulfotransferase family Guanylate_cyc PF00211.20 PIK62831.1 - 1.5e-62 210.5 0.4 1e-61 207.8 0.2 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 PIK62831.1 - 1.8e-46 158.9 0.6 3e-46 158.2 0.6 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.17 PIK62831.1 - 1.6e-26 93.1 0.3 1e-25 90.5 0.3 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62831.1 - 7.6e-23 81.2 0.0 1.9e-22 79.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Peripla_BP_6 PF13458.6 PIK62831.1 - 0.00015 21.5 0.4 0.00048 19.9 0.4 1.7 1 1 0 1 1 1 1 Periplasmic binding protein HNOBA PF07701.14 PIK62831.1 - 0.0036 16.7 0.2 0.0063 16.0 0.2 1.4 1 0 0 1 1 1 1 Heme NO binding associated VirJ PF06057.11 PIK62831.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) p450 PF00067.22 PIK62832.1 - 3.1e-120 402.1 0.0 3.5e-120 401.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ets PF00178.22 PIK62834.1 - 1.8e-34 118.0 2.2 3e-34 117.3 2.2 1.4 1 0 0 1 1 1 1 Ets-domain Neur_chan_LBD PF02931.23 PIK62835.1 - 2.2e-13 50.2 0.9 3.2e-13 49.6 0.9 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 PIK62835.1 - 1.4e-10 41.7 0.0 2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Peptidase_U4 PF03419.13 PIK62835.1 - 0.027 13.8 0.4 0.027 13.8 0.4 1.8 2 0 0 2 2 2 0 Sporulation factor SpoIIGA FAM176 PF14851.6 PIK62835.1 - 0.19 11.4 4.2 0.15 11.7 2.3 1.8 1 1 1 2 2 2 0 FAM176 family DUF3278 PF11683.8 PIK62835.1 - 1.1 9.4 8.5 0.86 9.7 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3278) UCR_hinge PF02320.16 PIK62836.1 - 7.8 6.8 10.8 1.9 8.8 2.5 3.5 3 1 1 4 4 4 0 Ubiquinol-cytochrome C reductase hinge protein GNT-I PF03071.15 PIK62837.1 - 3.2e-06 26.2 0.0 1.8e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 GNT-I family ILEI PF15711.5 PIK62838.1 - 4.4e-21 75.1 0.0 7e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer CBFD_NFYB_HMF PF00808.23 PIK62839.1 - 1.3e-28 99.0 0.3 2.1e-28 98.4 0.3 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 PIK62839.1 - 1.4e-06 28.7 0.1 2.2e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 PIK62839.1 - 0.00091 19.3 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 PIK62839.1 - 0.0013 18.8 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit PAN_3 PF08277.12 PIK62839.1 - 0.057 13.2 0.3 0.12 12.2 0.3 1.5 1 0 0 1 1 1 0 PAN-like domain CENP-X PF09415.10 PIK62839.1 - 0.073 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Runt PF00853.19 PIK62840.1 - 5.4e-13 48.6 0.0 9.5e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 Runt domain Peptidase_A17 PF05380.13 PIK62841.1 - 9.9e-34 116.7 0.0 1.4e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase zf-RVT PF13966.6 PIK62841.1 - 1.1e-06 29.3 1.8 1.1e-06 29.3 1.8 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Aminopep PF10023.9 PIK62842.1 - 0.0057 16.1 0.1 0.0081 15.6 0.1 1.1 1 0 0 1 1 1 1 Putative aminopeptidase DUF4371 PF14291.6 PIK62845.1 - 1.5e-09 37.9 0.2 2.3e-09 37.3 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) zf-CCHC PF00098.23 PIK62848.1 - 1.5e-06 28.0 16.2 0.00083 19.3 0.2 3.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_6 PF15288.6 PIK62848.1 - 0.0012 18.6 8.2 0.13 12.1 3.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 PIK62848.1 - 0.0093 15.9 12.8 0.29 11.1 1.2 3.5 1 1 2 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 PIK62848.1 - 0.028 14.3 0.2 0.028 14.3 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_10 PF16588.5 PIK62848.1 - 0.028 14.1 0.8 0.028 14.1 0.8 2.5 1 1 1 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 PIK62848.1 - 0.067 12.9 11.1 6.2 6.6 0.4 3.4 2 1 1 3 3 3 0 Zinc knuckle Yip1 PF04893.17 PIK62849.1 - 0.021 14.6 2.5 0.058 13.1 2.5 1.8 1 1 0 1 1 1 0 Yip1 domain ETRAMP PF09716.10 PIK62849.1 - 0.13 12.4 0.6 0.35 10.9 0.0 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) I-set PF07679.16 PIK62850.1 - 3.2e-166 539.9 7.8 1.3e-18 66.8 0.0 12.5 12 0 0 12 12 12 12 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK62850.1 - 3.2e-110 360.9 0.0 1.9e-11 44.4 0.0 12.7 12 0 0 12 12 12 12 Immunoglobulin domain ig PF00047.25 PIK62850.1 - 1.4e-65 217.5 1.1 4.7e-08 33.1 0.0 12.4 12 0 0 12 12 12 10 Immunoglobulin domain Ig_2 PF13895.6 PIK62850.1 - 1.2e-63 211.4 0.0 3.2e-06 27.4 0.0 12.1 12 0 0 12 12 12 11 Immunoglobulin domain V-set PF07686.17 PIK62850.1 - 2.3e-34 117.8 9.2 0.00088 19.4 0.0 14.6 10 5 1 11 11 11 7 Immunoglobulin V-set domain fn3 PF00041.21 PIK62850.1 - 2.6e-22 78.9 7.4 1.4e-17 63.7 1.5 4.0 4 0 0 4 4 2 2 Fibronectin type III domain Izumo-Ig PF16706.5 PIK62850.1 - 2.2e-10 40.5 5.1 8.5 6.5 0.0 10.0 11 1 1 12 12 11 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 PIK62850.1 - 4.2e-09 36.3 1.2 0.8 9.8 0.0 8.5 10 0 0 10 10 9 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 PIK62850.1 - 5.6e-06 26.6 6.7 7.3 7.1 0.0 9.5 11 0 0 11 11 11 1 Immunoglobulin C1-set domain Ig_4 PF16680.5 PIK62850.1 - 1.6e-05 25.1 2.2 3.9 7.8 0.0 6.6 8 0 0 8 8 7 1 T-cell surface glycoprotein CD3 delta chain BiPBP_C PF06832.12 PIK62850.1 - 0.00086 19.3 0.0 2.8 8.0 0.0 6.0 8 0 0 8 8 7 1 Penicillin-Binding Protein C-terminus Family AHSA1 PF08327.11 PIK62850.1 - 0.023 14.9 4.7 5.6 7.2 0.0 5.1 5 1 1 6 6 5 0 Activator of Hsp90 ATPase homolog 1-like protein Ig_6 PF18452.1 PIK62850.1 - 0.083 12.5 0.0 13 5.5 0.0 4.0 5 0 0 5 5 4 0 Immunoglobulin domain GH43_C2 PF17851.1 PIK62850.1 - 0.11 12.3 0.1 1.3 8.7 0.1 2.8 2 0 0 2 2 2 0 Beta xylosidase C-terminal Concanavalin A-like domain MBG_2 PF18676.1 PIK62850.1 - 0.11 13.2 6.5 1.4 9.6 0.1 4.6 5 0 0 5 5 3 0 MBG domain (YGX type) PepSY_2 PF13670.6 PIK62850.1 - 0.21 11.6 2.3 7 6.7 0.4 4.2 4 1 1 5 5 4 0 Peptidase propeptide and YPEB domain Pur_ac_phosph_N PF16656.5 PIK62850.1 - 1.2 9.8 4.8 1 10.0 0.5 3.2 3 0 0 3 3 2 0 Purple acid Phosphatase, N-terminal domain DUF11 PF01345.18 PIK62850.1 - 1.9 8.8 7.0 2.1 8.7 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function DUF11 fn3 PF00041.21 PIK62851.1 - 2.9e-65 216.6 4.4 1.3e-15 57.4 0.0 5.1 5 0 0 5 5 5 4 Fibronectin type III domain I-set PF07679.16 PIK62851.1 - 7e-41 138.2 3.4 5.2e-15 55.3 0.2 4.8 6 0 0 6 6 6 3 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK62851.1 - 4.9e-22 78.3 0.2 3.1e-06 27.7 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 PIK62851.1 - 2e-09 37.7 0.1 0.3 11.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 PIK62851.1 - 9.6e-09 35.3 1.7 0.052 13.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 PIK62851.1 - 6.5e-07 29.8 8.7 3.3 8.3 0.2 6.6 6 1 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 PIK62851.1 - 2.3e-06 27.7 0.2 0.19 11.9 0.0 4.4 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK62851.1 - 0.00012 22.1 0.2 1 9.5 0.0 3.5 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain fn3_2 PF16893.5 PIK62851.1 - 0.0048 17.0 0.1 12 6.2 0.0 4.6 5 1 0 5 5 5 1 Fibronectin type III domain DUF11 PF01345.18 PIK62851.1 - 0.0056 16.9 0.6 14 6.1 0.0 4.0 4 1 0 4 4 4 1 Domain of unknown function DUF11 Invasin_D3 PF09134.10 PIK62851.1 - 0.021 15.1 0.7 0.22 11.9 0.7 2.6 2 0 0 2 2 2 0 Invasin, domain 3 REJ PF02010.15 PIK62851.1 - 0.043 12.6 0.1 0.21 10.3 0.1 2.5 1 1 0 1 1 1 0 REJ domain DUF2369 PF10179.9 PIK62851.1 - 0.05 14.0 0.0 19 5.7 0.0 3.5 4 0 0 4 4 3 0 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 PIK62852.1 - 1.1e-73 243.6 10.7 7.9e-17 61.4 0.1 5.2 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 PIK62852.1 - 1.7e-15 56.8 0.0 6.4e-14 51.8 0.0 3.4 4 0 0 4 4 4 1 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 PIK62852.1 - 2.4e-11 44.0 10.9 0.058 14.0 1.0 6.6 5 4 0 5 5 5 5 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 PIK62852.1 - 1.2e-07 31.6 0.5 0.22 11.5 0.0 5.4 5 0 0 5 5 5 1 Y_Y_Y domain Tissue_fac PF01108.17 PIK62852.1 - 6.8e-06 25.9 0.0 0.86 9.5 0.0 4.0 3 0 0 3 3 3 2 Tissue factor Ig_3 PF13927.6 PIK62852.1 - 8.1e-05 23.2 0.8 0.00081 19.9 0.0 3.2 4 0 0 4 4 3 1 Immunoglobulin domain ChitinaseA_N PF08329.10 PIK62852.1 - 0.00013 21.7 0.1 0.28 10.8 0.0 2.8 3 0 0 3 3 3 2 Chitinase A, N-terminal domain DUF756 PF05506.12 PIK62852.1 - 0.00016 22.5 0.9 0.27 12.2 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF756) CRISPR_assoc PF08798.11 PIK62852.1 - 0.0038 17.4 0.0 7 6.7 0.0 3.8 4 1 0 5 5 5 1 CRISPR associated protein Reeler PF02014.16 PIK62852.1 - 0.016 15.9 3.2 13 6.6 0.2 4.5 4 1 0 4 4 4 0 Reeler domain DUF2369 PF10179.9 PIK62852.1 - 0.017 15.5 0.0 4 7.9 0.0 3.7 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 PIK62852.1 - 0.034 14.5 0.1 39 4.6 0.0 3.9 4 1 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III DUF11 PF01345.18 PIK62852.1 - 0.075 13.3 1.5 10 6.5 0.2 3.3 3 1 1 4 4 4 0 Domain of unknown function DUF11 CBM_6 PF03422.15 PIK62852.1 - 0.85 9.9 2.7 0.82 10.0 0.2 2.2 2 1 0 2 2 2 0 Carbohydrate binding module (family 6) fn3 PF00041.21 PIK62853.1 - 4.3e-15 55.8 0.7 1.1e-14 54.5 0.4 1.7 2 0 0 2 2 2 1 Fibronectin type III domain I-set PF07679.16 PIK62853.1 - 9.7e-05 22.4 2.0 0.00013 22.0 0.2 2.0 2 1 0 2 2 2 1 Immunoglobulin I-set domain Receptor_2B4 PF11465.8 PIK62853.1 - 0.0017 18.5 0.1 0.45 10.7 0.0 2.3 1 1 1 2 2 2 2 Natural killer cell receptor 2B4 Pur_ac_phosph_N PF16656.5 PIK62853.1 - 0.0059 17.1 2.8 0.013 16.1 1.0 2.3 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 PIK62853.1 - 0.074 13.2 0.7 0.16 12.2 0.0 1.8 2 1 0 2 2 2 0 Immunoglobulin V-set domain MBG PF17883.1 PIK62853.1 - 0.094 13.3 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 MBG domain DUF824 PF05688.11 PIK62853.1 - 0.095 12.5 0.2 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Ig_GlcNase PF18368.1 PIK62853.1 - 0.11 12.7 0.0 0.36 11.0 0.0 1.9 2 0 0 2 2 2 0 Exo-beta-D-glucosaminidase Ig-fold domain fn3 PF00041.21 PIK62854.1 - 2.5e-18 66.2 0.3 6.5e-14 52.0 0.0 2.1 2 0 0 2 2 2 2 Fibronectin type III domain I-set PF07679.16 PIK62855.1 - 3.6e-109 357.1 0.0 1.7e-17 63.2 0.0 8.8 9 0 0 9 9 9 7 Immunoglobulin I-set domain Ig_3 PF13927.6 PIK62855.1 - 5.4e-65 216.0 0.0 3.3e-12 46.8 0.0 8.3 9 0 0 9 9 8 6 Immunoglobulin domain Pkinase PF00069.25 PIK62855.1 - 1.3e-54 185.3 0.0 3.2e-54 184.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain fn3 PF00041.21 PIK62855.1 - 1.5e-50 169.5 0.8 3.6e-15 56.1 0.2 4.2 3 0 0 3 3 3 3 Fibronectin type III domain Ig_2 PF13895.6 PIK62855.1 - 5.1e-40 135.7 0.0 2.1e-07 31.2 0.0 8.0 9 0 0 9 9 9 6 Immunoglobulin domain ig PF00047.25 PIK62855.1 - 8.1e-36 122.1 3.0 8.2e-09 35.5 0.0 7.2 7 0 0 7 7 7 4 Immunoglobulin domain Pkinase_Tyr PF07714.17 PIK62855.1 - 6.8e-21 74.7 0.0 1.2e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase V-set PF07686.17 PIK62855.1 - 3.8e-15 56.0 5.3 0.089 13.0 0.0 8.9 7 4 0 7 7 7 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 PIK62855.1 - 3.7e-07 30.1 0.0 1.3 9.2 0.0 5.3 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.6 PIK62855.1 - 7.8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pur_ac_phosph_N PF16656.5 PIK62855.1 - 7.9e-07 29.6 6.1 0.16 12.5 0.0 5.1 5 0 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain V-set_CD47 PF08204.11 PIK62855.1 - 1.6e-06 28.1 0.0 0.45 10.5 0.0 3.7 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain Glyco_hydro_30C PF17189.4 PIK62855.1 - 0.18 12.0 0.3 2 8.7 0.4 2.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain SSF PF00474.17 PIK62856.1 - 2.5e-21 76.0 8.4 3.7e-21 75.5 8.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK62857.1 - 4.7e-34 117.9 24.3 6.6e-34 117.5 24.3 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 PIK62858.1 - 5e-43 147.5 29.1 6.4e-43 147.1 29.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family CBFD_NFYB_HMF PF00808.23 PIK62859.1 - 1e-11 44.9 0.0 1.7e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PHB_acc_N PF07879.11 PIK62859.1 - 0.031 14.3 0.1 0.69 10.0 0.0 2.2 1 1 1 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain gag-asp_proteas PF13975.6 PIK62860.1 - 0.00022 21.7 0.0 0.00076 20.0 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease ig PF00047.25 PIK62860.1 - 0.0097 16.1 0.5 1.6 9.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Asp_protease_2 PF13650.6 PIK62860.1 - 0.029 15.0 0.0 0.072 13.7 0.0 1.7 1 1 0 1 1 1 0 Aspartyl protease RVP PF00077.20 PIK62860.1 - 0.03 14.6 0.0 0.25 11.7 0.0 2.3 2 1 0 2 2 2 0 Retroviral aspartyl protease Ig_3 PF13927.6 PIK62860.1 - 0.13 12.9 0.4 1.4 9.6 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain RVT_1 PF00078.27 PIK62861.1 - 2.9e-17 62.9 0.1 4e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-set PF07686.17 PIK62864.1 - 0.00075 19.6 0.1 0.0052 16.9 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 PIK62864.1 - 0.015 15.9 0.1 19 5.9 0.0 3.1 2 1 1 3 3 3 0 Immunoglobulin domain C2-set_2 PF08205.12 PIK62864.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Pkinase_Tyr PF07714.17 PIK62865.1 - 8.5e-19 67.8 0.0 9e-19 67.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 PIK62865.1 - 5.4e-16 58.8 0.0 6.3e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PDEase_I PF00233.19 PIK62866.1 - 2.6e-51 174.7 0.0 7.9e-46 156.7 0.0 2.5 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Cytomega_UL84 PF06284.11 PIK62866.1 - 1.9 6.9 7.7 4 5.8 7.7 1.5 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Tox-PLDMTX PF15645.6 PIK62867.1 - 0.085 13.1 0.0 0.32 11.3 0.0 1.9 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold Peptidase_C14 PF00656.22 PIK62868.1 - 1.2e-16 61.4 0.0 1.5e-16 61.1 0.0 1.0 1 0 0 1 1 1 1 Caspase domain IFS PF16718.5 PIK62868.1 - 0.16 12.0 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Immunity factor for SPN Peptidase_C14 PF00656.22 PIK62869.1 - 3e-17 63.4 2.6 2.1e-10 41.0 0.1 2.0 2 0 0 2 2 2 2 Caspase domain Peptidase_C14 PF00656.22 PIK62870.1 - 6.7e-08 32.8 0.2 8.3e-08 32.5 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 PIK62871.1 - 1.3e-07 31.9 0.1 1.5e-07 31.6 0.1 1.1 1 0 0 1 1 1 1 Caspase domain DUF2576 PF10845.8 PIK62871.1 - 0.14 11.8 2.1 0.76 9.4 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2576) Peptidase_C14 PF00656.22 PIK62872.1 - 7.1e-26 91.7 0.1 9.1e-26 91.3 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Aldo_ket_red PF00248.21 PIK62873.1 - 2.9e-17 62.8 0.0 7.7e-17 61.4 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family rve PF00665.26 PIK62874.1 - 4.4e-24 84.9 0.0 8.6e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 PIK62874.1 - 6.8e-05 22.9 0.7 0.00017 21.6 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 PIK62874.1 - 0.00098 18.9 0.2 0.0053 16.5 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 PIK62875.1 - 6.7e-23 81.4 0.0 1.5e-22 80.2 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CC2-LZ PF16516.5 PIK62875.1 - 0.042 14.2 0.5 0.12 12.7 0.5 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Aldo_ket_red PF00248.21 PIK62876.1 - 2.9e-20 72.6 0.3 4.5e-20 72.0 0.0 1.4 2 0 0 2 2 2 1 Aldo/keto reductase family WSC PF01822.19 PIK62877.1 - 3.8e-18 65.5 15.1 5.6e-10 39.3 1.8 2.5 2 0 0 2 2 2 2 WSC domain Transcrip_act PF04949.13 PIK62877.1 - 0.044 13.7 0.9 0.079 12.8 0.9 1.4 1 0 0 1 1 1 0 Transcriptional activator eIF3_N PF09440.10 PIK62877.1 - 4.4 7.8 5.4 6.5 7.2 0.6 2.7 2 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain EF-hand_7 PF13499.6 PIK62878.1 - 9.6e-28 96.5 14.3 1.2e-09 38.5 1.8 6.7 6 1 1 7 7 7 6 EF-hand domain pair EF-hand_1 PF00036.32 PIK62878.1 - 1.2e-21 74.6 1.5 3.4e-05 23.1 0.0 7.6 9 0 0 9 9 9 5 EF hand EF-hand_6 PF13405.6 PIK62878.1 - 3.3e-19 67.1 9.9 0.00018 21.2 0.1 8.0 7 0 0 7 7 7 5 EF-hand domain EF-hand_8 PF13833.6 PIK62878.1 - 6.4e-14 51.5 4.3 3.3e-05 23.6 1.0 6.8 6 1 1 7 7 7 3 EF-hand domain pair EF-hand_11 PF08976.11 PIK62878.1 - 3.3e-10 40.8 1.6 0.032 15.1 0.1 6.1 7 0 0 7 7 7 3 EF-hand domain EF-hand_5 PF13202.6 PIK62878.1 - 5.6e-10 38.3 0.0 0.0067 15.9 0.0 4.5 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 PIK62878.1 - 0.025 14.9 0.8 0.54 10.6 0.1 3.2 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region NADPH_Ox PF08414.10 PIK62878.1 - 0.097 13.0 0.2 0.51 10.7 0.1 2.3 2 0 0 2 2 2 0 Respiratory burst NADPH oxidase EspF PF04806.12 PIK62878.1 - 0.57 10.6 7.8 1.4 9.4 7.8 1.7 1 0 0 1 1 1 0 EspF protein repeat Ribosomal_S8e PF01201.22 PIK62879.1 - 1.5e-48 164.5 6.2 1.5e-48 164.5 6.2 2.4 1 1 1 2 2 2 1 Ribosomal protein S8e DUF1768 PF08719.11 PIK62880.1 - 9.2e-28 97.5 0.1 1.2e-27 97.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Nucleos_tra2_N PF01773.20 PIK62881.1 - 1.2e-23 83.5 3.7 1.2e-23 83.5 3.7 2.8 2 1 1 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Corona_NS3b PF03053.14 PIK62881.1 - 0.00028 20.7 0.1 0.00063 19.6 0.1 1.6 1 0 0 1 1 1 1 ORF3b coronavirus protein PAP2 PF01569.21 PIK62881.1 - 0.00095 18.9 8.7 0.019 14.8 0.3 2.4 2 0 0 2 2 2 2 PAP2 superfamily DUF4401 PF14351.6 PIK62881.1 - 0.0041 16.5 13.2 0.082 12.2 1.7 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4401) DUF2070 PF09843.9 PIK62881.1 - 0.51 8.6 9.2 0.75 8.0 9.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1616 PF07760.11 PIK62881.1 - 1.1 8.6 3.6 0.36 10.2 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) BacA PF02673.18 PIK62881.1 - 1.2 8.7 7.8 43 3.7 6.8 2.3 1 1 0 1 1 1 0 Bacitracin resistance protein BacA DUF4191 PF13829.6 PIK62881.1 - 1.3 8.3 8.0 2.8 7.2 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) DUF2304 PF10066.9 PIK62881.1 - 2.1 8.6 15.3 4.4 7.6 0.9 2.8 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Herpes_LMP1 PF05297.11 PIK62881.1 - 3.3 6.8 6.9 52 2.9 9.1 1.7 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Lectin_C PF00059.21 PIK62882.1 - 1.1e-11 45.3 4.4 1.8e-11 44.7 1.3 2.1 2 0 0 2 2 2 1 Lectin C-type domain CbiQ PF02361.16 PIK62882.1 - 0.91 9.1 18.8 1.7 8.2 18.8 1.4 1 0 0 1 1 1 0 Cobalt transport protein EI24 PF07264.11 PIK62882.1 - 8.4 6.6 13.3 15 5.8 12.6 1.8 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) TraG_N PF07916.11 PIK62882.1 - 9.9 4.9 16.3 17 4.1 16.3 1.4 1 1 0 1 1 1 0 TraG-like protein, N-terminal region Ribosomal_S8e PF01201.22 PIK62883.1 - 0.0034 17.5 0.2 0.0036 17.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Nucleos_tra2_C PF07662.13 PIK62885.1 - 3.6e-77 258.9 5.0 3.6e-77 258.9 5.0 1.7 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 PIK62885.1 - 9.8e-19 67.7 1.3 9.8e-19 67.7 1.3 2.5 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 PIK62885.1 - 8.7e-10 38.9 4.9 8.7e-10 38.9 4.9 2.7 2 1 0 2 2 2 1 Nucleoside recognition TraT PF05818.12 PIK62885.1 - 0.21 11.2 2.0 7 6.3 0.4 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Asparaginase PF00710.20 PIK62887.1 - 1.2e-61 207.6 0.0 1.9e-61 207.0 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Ank_2 PF12796.7 PIK62887.1 - 8.9e-29 99.9 7.4 3.4e-11 43.6 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Asparaginase_C PF17763.1 PIK62887.1 - 7.2e-27 93.9 0.0 1.5e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_4 PF13637.6 PIK62887.1 - 2.7e-19 69.3 2.8 1.8e-09 38.0 0.1 4.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 PIK62887.1 - 2.7e-18 65.8 0.6 4.3e-08 33.3 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 PIK62887.1 - 3e-18 64.0 1.8 7.8e-06 25.9 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 PIK62887.1 - 6.6e-15 54.8 0.5 1.6e-05 25.1 0.0 5.6 5 0 0 5 5 5 2 Ankyrin repeat DUF4796 PF16044.5 PIK62887.1 - 0.17 11.4 0.0 20 4.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4796) RVT_1 PF00078.27 PIK62888.1 - 3.5e-30 105.2 1.5 7.5e-30 104.1 1.5 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CDPS PF16715.5 PIK62888.1 - 0.026 14.2 3.7 0.045 13.4 3.7 1.3 1 0 0 1 1 1 0 Cyclodipeptide synthase DUF4175 PF13779.6 PIK62888.1 - 0.041 11.8 0.6 0.062 11.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4441 PF14536.6 PIK62888.1 - 2.8 8.2 9.0 2.8 8.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) DDE_5 PF13546.6 PIK62889.1 - 0.081 12.3 0.1 0.098 12.0 0.1 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease zf-RVT PF13966.6 PIK62889.1 - 0.26 12.0 5.4 2.4 8.9 5.4 2.2 1 1 0 1 1 1 0 zinc-binding in reverse transcriptase DUF4509 PF14970.6 PIK62890.1 - 2.1e-20 73.5 3.7 2.2e-20 73.4 1.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4509) Methyltransf_1N PF02870.15 PIK62890.1 - 0.04 14.7 0.1 0.14 12.9 0.0 1.9 2 0 0 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain RAB3GAP2_N PF14655.6 PIK62892.1 - 1.2e-161 538.6 0.0 2e-161 537.9 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RAB3GAP2_C PF14656.6 PIK62892.1 - 1.4e-149 499.1 0.5 1.9e-149 498.7 0.0 1.4 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit C-terminus FAM83 PF07894.12 PIK62892.1 - 0.07 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 FAM83 A-H Rad51 PF08423.11 PIK62893.1 - 7e-49 166.4 0.0 8.9e-49 166.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 PIK62893.1 - 1.3e-06 28.2 0.0 2.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 PIK62893.1 - 2e-06 27.3 0.0 4.1e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.6 PIK62893.1 - 4.8e-06 26.9 0.4 1.4e-05 25.4 0.1 1.8 2 0 0 2 2 2 1 AAA domain RecA PF00154.21 PIK62893.1 - 0.00068 19.2 0.2 0.4 10.1 0.0 2.2 1 1 1 2 2 2 2 recA bacterial DNA recombination protein RNA_pol_A_CTD PF03118.15 PIK62893.1 - 0.0039 16.9 0.1 0.0079 15.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain DnaB_C PF03796.15 PIK62893.1 - 0.0094 15.3 0.2 0.12 11.6 0.2 2.2 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain HHH_5 PF14520.6 PIK62893.1 - 0.048 14.3 0.0 0.12 13.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain PDZ PF00595.24 PIK62894.1 - 1e-19 70.6 0.8 1e-19 70.6 0.8 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 PIK62894.1 - 1.6e-09 37.9 0.3 2.9e-09 37.1 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 PIK62894.1 - 2.3e-09 36.9 0.4 4.7e-09 36.0 0.4 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 PIK62894.1 - 0.0091 15.9 0.7 0.019 14.9 0.1 1.9 2 1 0 2 2 2 1 Tricorn protease PDZ domain CD36 PF01130.21 PIK62895.1 - 1.6e-125 419.3 4.4 1.9e-125 419.1 4.4 1.0 1 0 0 1 1 1 1 CD36 family CD36 PF01130.21 PIK62896.1 - 4.1e-29 101.4 0.0 5e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 CD36 family LapA_dom PF06305.11 PIK62896.1 - 0.0081 16.0 0.1 0.035 13.9 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain Saf_2TM PF18303.1 PIK62896.1 - 0.02 14.5 0.1 0.029 13.9 0.1 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF3611 PF12263.8 PIK62896.1 - 0.039 13.9 0.0 0.054 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF2678 PF10856.8 PIK62896.1 - 0.058 13.3 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) CD36 PF01130.21 PIK62897.1 - 3e-81 273.3 0.2 3.5e-81 273.1 0.2 1.0 1 0 0 1 1 1 1 CD36 family L_HMGIC_fpl PF10242.9 PIK62897.1 - 0.11 12.6 3.0 0.18 12.0 3.0 1.3 1 0 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein WD40 PF00400.32 PIK62898.1 - 7.6e-10 39.2 5.1 0.34 11.9 0.0 6.1 5 1 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 PIK62898.1 - 7.5e-06 25.5 1.7 0.75 9.1 0.9 3.5 1 1 1 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 PIK62898.1 - 0.024 14.9 0.8 20 5.5 0.0 3.9 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain SNAP-25 PF00835.19 PIK62902.1 - 7.9e-13 48.5 0.5 1.5e-12 47.7 0.5 1.4 1 0 0 1 1 1 1 SNAP-25 family Sec20 PF03908.13 PIK62902.1 - 0.18 11.8 1.4 0.3 11.0 1.4 1.4 1 0 0 1 1 1 0 Sec20 SNAP-25 PF00835.19 PIK62904.1 - 2.7e-14 53.2 4.6 5.8e-14 52.1 4.6 1.6 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 PIK62904.1 - 0.00011 22.1 11.3 0.00065 19.6 11.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 PIK62904.1 - 0.0012 19.1 7.5 0.0041 17.4 1.3 3.1 2 2 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus OEP PF02321.18 PIK62904.1 - 0.0045 16.8 1.3 0.0045 16.8 1.3 2.0 2 0 0 2 2 2 1 Outer membrane efflux protein Snapin_Pallidin PF14712.6 PIK62904.1 - 0.039 14.4 7.7 0.055 13.9 3.5 2.3 2 0 0 2 2 2 0 Snapin/Pallidin Sec20 PF03908.13 PIK62904.1 - 0.082 12.8 3.4 0.11 12.4 1.2 2.0 2 0 0 2 2 2 0 Sec20 Golgin_A5 PF09787.9 PIK62904.1 - 0.18 11.2 9.8 0.053 13.0 3.7 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 CCDC-167 PF15188.6 PIK62904.1 - 0.4 11.0 6.7 2.3 8.6 0.2 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 SOAR PF16533.5 PIK62904.1 - 0.54 10.3 4.1 0.72 9.9 0.0 2.8 2 2 0 3 3 3 0 STIM1 Orai1-activating region DUF16 PF01519.16 PIK62904.1 - 0.6 10.6 10.7 0.95 10.0 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 PIK62904.1 - 2 8.8 8.1 0.46 10.8 2.0 2.3 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 PIK62904.1 - 3.7 7.6 8.3 5.9 7.0 2.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cep57_CLD PF14073.6 PIK62904.1 - 4.2 7.3 12.9 0.36 10.8 6.1 2.4 2 2 0 2 2 2 0 Centrosome localisation domain of Cep57 FixQ PF05545.11 PIK62905.1 - 0.33 10.9 12.1 0.41 10.7 0.0 4.8 5 0 0 5 5 5 0 Cbb3-type cytochrome oxidase component FixQ DUF1077 PF06417.12 PIK62905.1 - 1.9 8.5 5.8 0.37 10.8 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1077) Sel1 PF08238.12 PIK62906.1 - 0.12 13.1 0.0 17 6.3 0.0 2.5 2 0 0 2 2 2 0 Sel1 repeat Tli4_N PF18443.1 PIK62906.1 - 3.1 8.2 5.4 1.4 9.3 1.0 2.4 3 0 0 3 3 3 0 Tle cognate immunity protein 4 N-terminal domain Sel1 PF08238.12 PIK62907.1 - 1.2e-47 159.3 27.6 7.6e-08 32.8 0.1 9.5 9 0 0 9 9 9 8 Sel1 repeat TPR_16 PF13432.6 PIK62907.1 - 0.16 12.6 20.3 14 6.4 0.1 5.9 4 1 2 6 6 6 0 Tetratricopeptide repeat Adap_comp_sub PF00928.21 PIK62908.1 - 5.3e-23 81.7 0.1 7.6e-23 81.2 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family EF-hand_7 PF13499.6 PIK62909.1 - 4.9e-05 23.7 0.4 0.00058 20.3 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 PIK62909.1 - 0.00014 21.1 0.1 0.00031 20.1 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 PIK62909.1 - 0.00022 20.9 0.1 0.00066 19.4 0.1 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 PIK62909.1 - 0.00066 19.1 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 EF hand COBRA1 PF06209.13 PIK62909.1 - 0.16 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) 7tm_1 PF00001.21 PIK62912.1 - 1.8e-47 161.9 5.3 2.4e-47 161.5 5.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 PIK62912.1 - 3.6e-09 36.6 14.0 3.6e-09 36.6 14.0 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 PIK62912.1 - 1.4e-05 25.0 8.4 3.8e-05 23.6 0.5 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK62912.1 - 9.8e-05 21.8 17.0 0.0034 16.8 6.7 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1980 PF09323.10 PIK62912.1 - 0.026 14.5 0.0 0.026 14.5 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) DUF1218 PF06749.12 PIK62912.1 - 7.8 7.1 7.8 0.86 10.2 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) UL45 PF05473.12 PIK62913.1 - 0.0014 18.3 0.3 0.0026 17.5 0.1 1.5 1 1 1 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 PIK62913.1 - 0.0017 19.0 0.1 0.014 16.1 0.1 2.1 1 1 0 1 1 1 1 Lectin C-type domain RVT_1 PF00078.27 PIK62915.1 - 6.4e-07 29.1 0.0 7.5e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S10 PF00338.22 PIK62916.1 - 1.5e-19 70.1 0.0 1.6e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fibrinogen_C PF00147.18 PIK62917.1 - 8.2e-51 172.9 4.5 9e-51 172.8 4.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CFC PF09443.10 PIK62917.1 - 3.9 7.4 5.8 0.84 9.5 2.4 1.6 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) SRCR PF00530.18 PIK62918.1 - 2.5e-57 191.5 9.3 5.5e-30 103.8 2.9 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 PIK62918.1 - 1.7e-15 57.3 4.6 1.5e-07 31.9 0.5 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 PIK62918.1 - 1.2e-09 38.6 0.8 0.0019 18.7 0.1 2.6 2 1 0 2 2 2 2 Hepsin, SRCR domain zf-C2H2_4 PF13894.6 PIK62920.1 - 1 10.4 7.8 0.78 10.7 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK62920.1 - 2.5 8.7 6.7 0.35 11.4 0.8 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 PIK62920.1 - 8.8 6.7 7.0 19 5.7 0.3 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding GRIP PF01465.20 PIK62922.1 - 1.8e-10 40.5 0.1 5.2e-10 39.1 0.1 1.9 1 0 0 1 1 1 1 GRIP domain Alpha-2-MRAP_C PF06401.11 PIK62922.1 - 0.0032 17.5 41.0 0.0032 17.5 41.0 5.5 2 1 1 4 4 4 1 Alpha-2-macroglobulin RAP, C-terminal domain ABC_tran_CTD PF16326.5 PIK62922.1 - 0.011 16.0 3.1 0.011 16.0 3.1 12.7 2 1 9 11 11 11 0 ABC transporter C-terminal domain DUF4763 PF15960.5 PIK62923.1 - 0.008 15.5 14.9 0.008 15.5 14.9 5.0 3 1 1 5 5 5 2 Domain of unknown function (DUF4763) HMMR_C PF15908.5 PIK62923.1 - 0.06 13.6 0.3 0.06 13.6 0.3 6.8 5 3 3 8 8 8 0 Hyaluronan mediated motility receptor C-terminal Cnn_1N PF07989.11 PIK62924.1 - 7.7e-19 67.6 10.4 7.7e-19 67.6 10.4 15.9 9 5 3 12 12 12 2 Centrosomin N-terminal motif 1 2_5_RNA_ligase2 PF13563.6 PIK62924.1 - 0.0088 16.0 0.4 0.17 11.8 0.0 3.4 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily Surfac_D-trimer PF09006.11 PIK62924.1 - 0.035 14.0 1.1 0.31 11.0 1.1 2.8 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation DUF5055 PF16478.5 PIK62924.1 - 3.2 8.0 7.4 18 5.6 0.1 4.6 4 1 1 5 5 5 0 Domain of unknown function (DUF5055) Spectrin_like PF18373.1 PIK62924.1 - 7.6 6.7 16.9 0.93 9.6 6.8 4.4 3 1 0 3 3 3 0 Spectrin like domain Proteasome PF00227.26 PIK62925.1 - 1.7e-50 171.2 0.4 2e-50 170.9 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 PIK62925.1 - 6.8e-17 60.6 0.2 6.8e-17 60.6 0.2 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Pkinase PF00069.25 PIK62926.1 - 4.9e-33 114.6 1.1 6.5e-33 114.2 1.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK62926.1 - 1.4e-23 83.5 0.5 1.9e-23 83.1 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK62926.1 - 0.0028 17.0 0.1 0.0048 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF309 PF03745.14 PIK62926.1 - 0.073 12.8 0.1 0.6 9.8 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF309) PMT PF02366.18 PIK62927.1 - 6.7e-60 202.7 23.8 6.7e-60 202.7 23.8 2.4 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 PIK62927.1 - 1.8e-54 184.4 11.0 1.8e-54 184.4 11.0 2.6 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 PIK62927.1 - 1.6e-09 37.9 0.0 3.3e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 MIR domain DUF1295 PF06966.12 PIK62928.1 - 6.4e-49 166.6 4.4 1.6e-48 165.2 4.4 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 PIK62928.1 - 0.00056 20.3 0.3 0.0053 17.2 0.1 2.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 PIK62928.1 - 0.00095 19.5 0.3 0.0043 17.4 0.1 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF4271 PF14093.6 PIK62928.1 - 0.11 12.3 0.2 0.11 12.3 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) zf-U1 PF06220.12 PIK62929.1 - 0.064 13.0 1.1 0.16 11.8 1.1 1.6 1 0 0 1 1 1 0 U1 zinc finger zf-C2HC_2 PF13913.6 PIK62929.1 - 0.079 12.9 0.2 0.18 11.8 0.2 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 PIK62929.1 - 0.089 13.1 10.5 0.28 11.5 2.7 2.9 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 PIK62929.1 - 0.9 10.5 6.0 1.3 10.0 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 PIK62929.1 - 1.5 9.3 4.9 0.79 10.2 0.9 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 PIK62930.1 - 7.7e-06 26.2 8.0 0.036 14.4 0.3 3.3 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 PIK62930.1 - 0.051 13.5 0.2 0.16 11.9 0.2 1.9 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-U1 PF06220.12 PIK62930.1 - 0.085 12.6 3.8 0.14 11.9 1.1 2.5 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_jaz PF12171.8 PIK62930.1 - 0.31 11.4 26.0 0.25 11.7 2.7 4.3 3 2 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 PIK62930.1 - 1.2 9.4 18.4 6.8 6.9 1.8 4.5 4 1 1 5 5 5 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.6 PIK62930.1 - 3 8.9 13.0 1.2 10.2 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger DUF913 PF06025.12 PIK62930.1 - 8.2 5.3 7.7 1.9 7.4 0.3 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Ribosomal_L28e PF01778.17 PIK62933.1 - 1.1e-26 93.8 0.1 1.5e-26 93.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family TruB_N PF01509.18 PIK62934.1 - 2.4e-10 41.0 0.0 4.1e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) SAP PF02037.27 PIK62935.1 - 2.2e-06 27.3 1.2 2.2e-06 27.3 1.2 2.0 3 0 0 3 3 3 1 SAP domain Ish1 PF10281.9 PIK62935.1 - 0.022 15.1 0.2 0.045 14.0 0.2 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Telomere_Sde2_2 PF13297.6 PIK62935.1 - 0.048 13.3 0.1 0.12 12.0 0.1 1.6 2 0 0 2 2 2 0 Telomere stability C-terminal LRR_8 PF13855.6 PIK62936.1 - 1.3e-28 98.5 21.5 5.7e-11 42.0 3.4 4.9 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK62936.1 - 8.4e-14 51.5 21.4 7.2e-05 23.1 0.8 5.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK62936.1 - 2.3e-08 34.0 1.6 2.7e-05 24.1 0.6 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 PIK62936.1 - 1.5e-05 24.6 2.4 0.038 13.5 0.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 PIK62936.1 - 0.00083 19.6 18.4 6.1 7.8 0.1 7.7 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.6 PIK62936.1 - 1.1 9.4 14.5 7.7 6.8 0.1 6.2 7 0 0 7 7 7 0 Leucine Rich repeat LRR_8 PF13855.6 PIK62937.1 - 5.1e-24 83.8 12.9 2.2e-13 49.8 0.5 4.5 1 1 4 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 PIK62937.1 - 4.2e-11 42.9 5.3 0.0078 16.6 0.1 5.6 3 3 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 PIK62937.1 - 1.5e-06 28.1 1.1 0.0014 18.6 0.0 1.8 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 PIK62937.1 - 2.4e-06 27.1 2.3 1.2 9.3 0.0 5.5 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 PIK62937.1 - 4.7e-06 26.4 4.2 3.9 8.4 0.0 5.9 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 PIK62937.1 - 2.5e-05 23.8 0.7 0.006 16.1 0.0 2.3 1 1 2 3 3 3 3 Leucine-rich repeat Dynamin_M PF01031.20 PIK62938.1 - 7.1e-69 232.2 1.4 8.6e-69 231.9 1.4 1.1 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 PIK62938.1 - 1.3e-33 116.4 0.0 2.9e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 Dynamin family RILP PF11461.8 PIK62938.1 - 0.064 13.5 1.1 0.19 12.0 0.2 2.1 2 0 0 2 2 2 0 Rab interacting lysosomal protein GED PF02212.18 PIK62939.1 - 1.2e-27 95.9 1.2 1.9e-27 95.2 1.2 1.3 1 0 0 1 1 1 1 Dynamin GTPase effector domain Dynamin_M PF01031.20 PIK62939.1 - 3.3e-13 49.5 0.8 6.4e-13 48.6 0.2 1.7 2 0 0 2 2 2 1 Dynamin central region PH PF00169.29 PIK62939.1 - 8.6e-12 45.5 0.2 1.4e-11 44.8 0.2 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 PIK62939.1 - 0.46 10.9 2.4 60 4.1 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain Peptidase_S8 PF00082.22 PIK62940.1 - 4.8e-97 324.8 1.4 7.1e-97 324.3 1.4 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 PIK62940.1 - 1.7e-73 246.1 0.0 2.9e-73 245.4 0.0 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II TPPII_N PF12583.8 PIK62940.1 - 4.8e-05 24.0 0.2 0.00013 22.6 0.2 1.7 1 0 0 1 1 1 1 Tripeptidyl peptidase II N terminal RGM_C PF06534.13 PIK62940.1 - 0.048 13.2 0.2 0.11 12.0 0.2 1.5 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) C-terminus RXT2_N PF08595.11 PIK62942.1 - 0.11 12.5 7.9 0.16 12.0 7.9 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 PIK62942.1 - 6.7 6.4 14.7 7.9 6.1 14.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Phage_int_SAM_4 PF13495.6 PIK62943.1 - 0.00016 22.0 0.1 0.00031 21.1 0.1 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 PIK62943.1 - 0.00053 20.2 0.3 0.001 19.3 0.3 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_5 PF13102.6 PIK62943.1 - 0.17 12.3 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain F-box-like PF12937.7 PIK62945.1 - 1.4e-12 47.3 1.6 2.1e-12 46.7 1.6 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 PIK62945.1 - 1.5e-11 43.9 1.5 3.3e-11 42.8 1.5 1.5 1 0 0 1 1 1 1 F-box domain SPRY PF00622.28 PIK62945.1 - 8.5e-05 22.7 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 SPRY domain F-box_5 PF18511.1 PIK62945.1 - 0.09 12.4 1.5 0.52 9.9 1.5 2.1 1 1 0 1 1 1 0 F-box Autophagy_N PF03986.13 PIK62946.1 - 5.4e-47 159.2 1.6 5.4e-47 159.2 1.6 1.8 1 1 1 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 PIK62946.1 - 3e-21 75.8 1.8 6.8e-21 74.6 1.8 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 PIK62946.1 - 5.3e-16 57.8 0.7 1.1e-15 56.9 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal SDA1 PF05285.12 PIK62946.1 - 0.053 12.9 9.0 0.042 13.3 7.9 1.4 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 PIK62946.1 - 0.7 8.0 5.2 0.77 7.9 5.2 1.1 1 0 0 1 1 1 0 Nop14-like family AAA_34 PF13872.6 PIK62947.1 - 2.4e-124 414.1 0.0 3.8e-124 413.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 PIK62947.1 - 2.5e-113 378.3 1.2 3.8e-113 377.7 1.2 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 PIK62947.1 - 0.0015 18.5 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 PIK62947.1 - 0.094 13.1 0.1 0.28 11.5 0.1 1.8 1 0 0 1 1 1 0 Helicase conserved C-terminal domain ANF_receptor PF01094.28 PIK62948.1 - 1.7e-49 168.8 0.1 2.3e-49 168.4 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 PIK62948.1 - 1.2e-08 35.1 0.0 1.6e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein POB3_N PF17292.2 PIK62949.1 - 7.4e-27 93.6 0.4 4e-24 84.9 0.1 2.8 2 0 0 2 2 2 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 PIK62949.1 - 9.4e-24 83.7 0.0 3.3e-23 81.9 0.0 2.0 1 0 0 1 1 1 1 Histone chaperone Rttp106-like HMG_box PF00505.19 PIK62949.1 - 1.7e-16 60.4 4.7 1.7e-16 60.4 4.7 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 PIK62949.1 - 1e-11 45.3 4.5 1e-11 45.3 4.5 2.5 2 0 0 2 2 2 1 HMG-box domain SSrecog PF03531.14 PIK62949.1 - 1.2e-10 41.1 4.6 9.6e-10 38.2 0.3 2.7 1 1 1 2 2 2 2 Structure-specific recognition protein (SSRP1) Fibrinogen_C PF00147.18 PIK62950.1 - 1.5e-35 123.0 0.5 2.1e-35 122.5 0.5 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ail_Lom PF06316.11 PIK62950.1 - 0.15 11.8 3.8 2.6 7.7 0.4 2.3 1 1 1 2 2 2 0 Enterobacterial Ail/Lom protein Njmu-R1 PF15053.6 PIK62950.1 - 0.48 9.5 4.4 6.9 5.7 0.1 2.5 2 1 1 3 3 3 0 Mjmu-R1-like protein family ApoL PF05461.11 PIK62951.1 - 5.8e-05 22.6 0.2 0.0049 16.2 0.1 2.2 2 0 0 2 2 2 2 Apolipoprotein L ApoL PF05461.11 PIK62952.1 - 9.6e-05 21.9 0.1 0.09 12.1 0.0 2.3 2 0 0 2 2 2 2 Apolipoprotein L YtzH PF14165.6 PIK62952.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 YtzH-like protein Phage_holin_3_6 PF07332.11 PIK62952.1 - 0.19 11.8 6.2 0.072 13.1 0.9 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III C2-set_2 PF08205.12 PIK62954.1 - 0.0012 18.8 0.3 0.69 10.0 0.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 PIK62954.1 - 0.0016 18.6 0.5 2.3 8.5 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 PIK62954.1 - 0.0024 18.4 2.0 2.6 8.7 0.0 3.3 3 1 0 3 3 3 2 Immunoglobulin domain Phage_holin_3_6 PF07332.11 PIK62954.1 - 0.0038 17.2 6.8 0.12 12.4 3.7 2.2 2 0 0 2 2 2 2 Putative Actinobacterial Holin-X, holin superfamily III V-set PF07686.17 PIK62954.1 - 0.0058 16.8 0.3 0.13 12.5 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 PIK62954.1 - 0.0064 16.8 0.4 1.8 8.9 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain DUF4781 PF16013.5 PIK62954.1 - 0.046 12.5 2.4 0.099 11.4 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) LVIVD PF08309.11 PIK62954.1 - 0.074 12.4 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 LVIVD repeat LapA_dom PF06305.11 PIK62954.1 - 0.25 11.2 6.0 2.3 8.1 0.1 2.6 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain KIAA1430 PF13879.6 PIK62955.1 - 1.2e-27 96.7 11.1 1.2e-27 96.7 11.1 1.9 3 0 0 3 3 3 1 KIAA1430 homologue Pinin_SDK_memA PF04696.13 PIK62955.1 - 0.71 9.9 11.0 0.17 12.0 6.9 2.0 1 1 1 2 2 2 0 pinin/SDK/memA/ protein conserved region Ion_trans PF00520.31 PIK62956.1 - 8.9e-28 97.1 31.5 2e-26 92.7 31.5 2.1 1 1 0 1 1 1 1 Ion transport protein WSC PF01822.19 PIK62957.1 - 2e-32 111.2 19.9 9.1e-19 67.4 10.0 2.4 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.27 PIK62957.1 - 6.7e-08 32.3 0.0 5e-07 29.5 0.0 2.0 1 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 PIK62957.1 - 0.0001 22.8 0.0 0.00029 21.3 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family DUF108 PF01958.18 PIK62958.1 - 7.2e-23 80.8 0.0 1.1e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.16 PIK62958.1 - 5.3e-11 43.2 0.0 8.8e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 PIK62958.1 - 0.00016 21.8 0.0 0.00029 21.0 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 PIK62958.1 - 0.031 13.6 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 PIK62958.1 - 0.047 14.0 0.0 0.54 10.6 0.0 2.3 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 PIK62958.1 - 0.13 12.5 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 PIK62958.1 - 0.17 12.5 0.0 0.41 11.2 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PrmA PF06325.13 PIK62959.1 - 3.2e-11 43.2 0.0 3.9e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 PIK62959.1 - 5.4e-07 29.3 0.0 9.4e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 PIK62959.1 - 3.6e-05 23.6 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 PIK62959.1 - 0.00019 21.2 0.0 0.00023 21.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 PIK62959.1 - 0.0004 21.0 0.1 0.00091 19.9 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain TRM PF02005.16 PIK62959.1 - 0.0025 17.1 0.0 0.0026 17.0 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.15 PIK62959.1 - 0.0043 16.7 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 PIK62959.1 - 0.029 13.9 0.1 0.046 13.3 0.1 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_9 PF08003.11 PIK62959.1 - 0.042 12.8 0.0 0.056 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 PIK62959.1 - 0.068 12.9 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 PIK62959.1 - 0.14 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase HLH PF00010.26 PIK62960.1 - 2.8e-13 49.6 0.3 7.4e-13 48.3 0.3 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RabGAP-TBC PF00566.18 PIK62961.1 - 4.9e-35 121.1 2.1 6.6e-35 120.7 2.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 PIK62962.1 - 1.9e-34 118.6 0.0 5.7e-34 117.0 0.0 1.8 2 0 0 2 2 2 1 Rab-binding domain (RBD) RUN PF02759.19 PIK62962.1 - 2e-31 108.8 0.0 5.5e-31 107.3 0.0 1.8 1 0 0 1 1 1 1 RUN domain UDPGT PF00201.18 PIK62963.1 - 1.3e-45 156.2 0.0 1.5e-45 156.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ArgoN PF16486.5 PIK62964.1 - 0.00056 20.5 0.0 0.00099 19.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute GAGE PF05831.11 PIK62964.1 - 0.52 10.9 10.0 0.35 11.4 7.8 1.9 2 0 0 2 2 2 0 GAGE protein Piwi PF02171.17 PIK62965.1 - 9.1e-85 284.5 0.1 2.6e-84 283.0 0.1 1.7 1 1 0 1 1 1 1 Piwi domain PAZ PF02170.22 PIK62965.1 - 5.9e-27 94.1 0.6 1.1e-26 93.3 0.6 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 PIK62965.1 - 0.0013 19.0 0.0 0.004 17.5 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain RT_RNaseH PF17917.1 PIK62966.1 - 6.9e-21 74.5 0.0 1.3e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 PIK62966.1 - 1.3e-16 60.4 0.8 2.6e-16 59.4 0.8 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 PIK62966.1 - 9.6e-13 48.0 0.0 1.9e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK62966.1 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PNMA PF14893.6 PIK62967.1 - 0.00029 20.4 0.1 0.00033 20.2 0.1 1.2 1 0 0 1 1 1 1 PNMA Sipho_Gp157 PF05565.11 PIK62968.1 - 0.37 10.8 8.5 0.13 12.3 0.5 2.7 2 1 1 3 3 3 0 Siphovirus Gp157 Cnn_1N PF07989.11 PIK62968.1 - 2.3 8.5 13.1 0.81 9.9 5.0 2.8 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Prominin PF05478.11 PIK62968.1 - 6.2 4.7 11.2 7.7 4.3 11.2 1.1 1 0 0 1 1 1 0 Prominin TRC8_N PF13705.6 PIK62969.1 - 3.2e-127 425.5 32.0 4.7e-127 424.9 32.0 1.3 1 1 0 1 1 1 1 TRC8 N-terminal domain zf-C3HC4_2 PF13923.6 PIK62969.1 - 5.2e-11 42.2 6.7 1e-10 41.2 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK62969.1 - 9.8e-11 41.8 7.0 1.8e-10 41.0 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 PIK62969.1 - 4.2e-08 33.3 5.2 1.2e-07 31.8 5.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 PIK62969.1 - 1.1e-07 31.5 5.8 2.4e-07 30.5 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 PIK62969.1 - 2.4e-06 27.3 4.9 4.4e-06 26.5 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 PIK62969.1 - 4.3e-06 26.5 4.5 7.9e-06 25.6 4.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 PIK62969.1 - 1.1e-05 25.3 3.3 2.3e-05 24.3 3.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 PIK62969.1 - 1.5e-05 24.8 6.7 2.6e-05 24.1 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 PIK62969.1 - 7e-05 22.5 3.3 0.00017 21.3 3.3 1.7 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 PIK62969.1 - 0.0017 18.0 5.6 0.0055 16.3 5.6 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 PIK62969.1 - 0.015 15.3 6.3 0.07 13.2 6.3 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 PIK62969.1 - 0.13 12.4 2.7 0.28 11.3 2.7 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 RINGv PF12906.7 PIK62969.1 - 0.26 11.4 5.1 0.57 10.4 5.1 1.6 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 PIK62969.1 - 0.4 10.8 3.5 0.97 9.6 3.5 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 PIK62969.1 - 1.1 9.4 5.6 3.8 7.8 5.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.14 PIK62969.1 - 1.4 8.7 4.0 23 4.8 4.0 2.7 1 1 1 2 2 2 0 P-11 zinc finger Neuralized PF07177.12 PIK62970.1 - 1.2e-36 126.0 0.0 1.6e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Neuralized zf-C3HC4_3 PF13920.6 PIK62970.1 - 1e-13 50.9 11.6 1.5e-13 50.4 11.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 PIK62970.1 - 0.00069 19.9 12.3 0.0011 19.3 12.3 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 PIK62970.1 - 0.00079 19.2 11.7 0.0013 18.5 11.7 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 PIK62970.1 - 0.00079 19.2 13.6 0.0012 18.6 13.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 PIK62971.1 - 4e-44 150.5 0.0 4.7e-43 147.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 PIK62971.1 - 6.9e-30 103.6 0.0 3e-29 101.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 PIK62971.1 - 0.00037 20.5 0.0 0.00074 19.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 PIK62971.1 - 0.004 17.2 1.7 0.004 17.2 1.7 2.3 3 0 0 3 3 3 1 Zinc knuckle PRAI PF00697.22 PIK62971.1 - 0.13 12.0 0.2 0.21 11.3 0.2 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase zf-CCHC_4 PF14392.6 PIK62971.1 - 0.15 11.8 0.8 0.37 10.6 0.8 1.7 1 0 0 1 1 1 0 Zinc knuckle MFS_1 PF07690.16 PIK62972.1 - 6.6e-17 61.5 31.9 2.6e-15 56.2 32.7 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily KASH_CCD PF14662.6 PIK62973.1 - 0.025 14.4 1.7 0.27 11.1 0.1 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF1910 PF08928.10 PIK62973.1 - 0.034 14.1 3.0 0.57 10.2 0.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF1910) Myosin_tail_1 PF01576.19 PIK62973.1 - 0.041 11.7 0.8 0.051 11.4 0.8 1.0 1 0 0 1 1 1 0 Myosin tail CHD5 PF04420.14 PIK62973.1 - 0.087 12.7 2.9 2.3 8.0 0.2 2.1 2 0 0 2 2 2 0 CHD5-like protein Fungal_TACC PF12709.7 PIK62973.1 - 0.088 13.3 5.2 0.16 12.4 1.7 2.3 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins BRE1 PF08647.11 PIK62973.1 - 0.14 12.2 4.6 0.99 9.5 4.5 2.0 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase p450 PF00067.22 PIK62974.1 - 1.5e-53 182.2 0.0 1.7e-53 182.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62975.1 - 1.2e-33 116.6 0.1 1.4e-33 116.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 PIK62976.1 - 1.3e-37 129.6 0.0 1.7e-37 129.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.21 PIK62977.1 - 2.1e-80 269.9 6.2 3.6e-80 269.1 6.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 PIK62977.1 - 7.4e-06 25.9 13.3 0.00019 21.3 9.6 2.7 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 PIK62977.1 - 8.5e-05 22.1 15.8 0.002 17.6 10.6 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 PIK62977.1 - 0.0019 17.9 14.8 0.0019 17.9 14.8 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Neurensin PF14927.6 PIK62977.1 - 0.57 9.9 4.7 1.3 8.8 0.2 2.8 2 1 1 3 3 3 0 Neurensin NPM1-C PF16276.5 PIK62978.1 - 0.012 15.6 1.2 0.012 15.6 1.2 2.4 1 1 1 2 2 2 0 Nucleophosmin C-terminal domain Allantoicase PF03561.15 PIK62978.1 - 0.12 12.3 0.3 0.13 12.2 0.3 1.0 1 0 0 1 1 1 0 Allantoicase repeat Nucleoplasmin PF03066.15 PIK62979.1 - 3.1e-06 27.6 0.0 6.2e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain ORC6 PF05460.13 PIK62979.1 - 0.12 11.7 1.3 0.14 11.5 1.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ras PF00071.22 PIK62980.1 - 1.5e-58 197.0 0.3 1.8e-58 196.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 PIK62980.1 - 3.9e-36 123.9 0.2 6.1e-36 123.3 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 PIK62980.1 - 2.7e-15 56.3 0.1 3.2e-15 56.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 PIK62980.1 - 2e-06 27.5 0.1 2.3e-05 24.0 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 PIK62980.1 - 7.1e-06 25.6 0.1 9.9e-06 25.1 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 PIK62980.1 - 4e-05 23.7 0.0 6.6e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 PIK62980.1 - 7.3e-05 22.3 0.2 0.0017 17.9 0.2 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 PIK62980.1 - 0.00018 20.9 0.2 0.00022 20.7 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 PIK62980.1 - 0.0002 21.3 0.1 0.12 12.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase DUF1854 PF08909.11 PIK62980.1 - 0.071 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) AAA_7 PF12775.7 PIK62980.1 - 0.091 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Motile_Sperm PF00635.26 PIK62981.1 - 5.7e-15 55.1 0.0 9.8e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Pyr_redox_2 PF07992.14 PIK62982.1 - 1.8e-47 162.0 2.6 2.2e-47 161.7 2.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 PIK62982.1 - 3.9e-14 53.0 0.6 9.6e-11 42.1 0.2 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 PIK62982.1 - 3.6e-10 39.6 1.9 2.4e-07 30.3 0.5 2.7 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 PIK62982.1 - 2.6e-08 33.9 5.2 0.011 15.3 0.1 4.1 3 1 1 4 4 4 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 PIK62982.1 - 6.2e-08 32.8 2.0 0.098 12.6 0.0 4.2 3 1 1 4 4 4 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 PIK62982.1 - 3.2e-07 29.8 0.5 0.0023 17.2 0.1 2.7 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 PIK62982.1 - 6e-06 25.6 0.6 0.4 9.7 0.0 4.0 3 1 1 4 4 4 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 PIK62982.1 - 1.3e-05 25.6 4.5 0.0011 19.4 0.0 2.7 2 1 0 2 2 2 1 Putative NAD(P)-binding TrkA_N PF02254.18 PIK62982.1 - 0.00023 21.4 0.7 0.8 10.0 0.0 2.9 3 0 0 3 3 3 2 TrkA-N domain GIDA PF01134.22 PIK62982.1 - 0.00024 20.3 9.5 0.16 11.1 0.0 4.1 4 1 1 5 5 5 3 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 PIK62982.1 - 0.0004 19.8 0.0 0.083 12.2 0.0 2.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 PIK62982.1 - 0.0016 18.5 1.0 0.28 11.2 0.0 3.4 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 PIK62982.1 - 0.0025 18.0 0.4 0.37 11.1 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DUF1188 PF06690.11 PIK62982.1 - 0.0042 16.7 0.1 0.037 13.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) HI0933_like PF03486.14 PIK62982.1 - 0.0049 15.6 1.2 6.3 5.4 0.0 3.8 4 0 0 4 4 4 1 HI0933-like protein Trp_halogenase PF04820.14 PIK62982.1 - 0.0079 15.1 5.9 3 6.6 0.0 3.9 2 2 1 4 4 4 1 Tryptophan halogenase ThiF PF00899.21 PIK62982.1 - 0.017 14.5 0.1 0.17 11.2 0.0 2.2 2 0 0 2 2 2 0 ThiF family HycI PF01750.18 PIK62982.1 - 0.039 13.8 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase maturation protease KOW PF00467.29 PIK62982.1 - 1.8 8.6 5.6 13 6.0 0.1 3.0 3 0 0 3 3 3 0 KOW motif FAM70 PF14967.6 PIK62983.1 - 8.1e-07 28.8 29.8 4.1e-06 26.5 29.8 2.0 1 1 0 1 1 1 1 FAM70 protein DUF3993 PF13158.6 PIK62984.1 - 1.1 9.5 3.5 0.84 9.9 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) Transketolase_N PF00456.21 PIK62984.1 - 2.9 6.8 7.5 3.1 6.7 6.3 1.7 1 1 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain T2SSF PF00482.23 PIK62984.1 - 9.9 6.1 6.2 6.9 6.6 3.3 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F UCH PF00443.29 PIK62985.1 - 3e-27 95.7 0.0 4.1e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 PIK62985.1 - 6.2e-09 35.9 1.2 9.2e-07 28.7 0.3 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_5 PF17121.5 PIK62985.1 - 2.5 8.0 6.0 1.1 9.2 2.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) UCH PF00443.29 PIK62986.1 - 2e-08 34.1 0.8 5.1e-08 32.7 0.8 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Importin_rep_4 PF18808.1 PIK62987.1 - 2e-26 92.1 0.5 2e-26 92.1 0.5 3.5 5 0 0 5 5 4 1 Importin repeat HEAT PF02985.22 PIK62987.1 - 3.5e-14 51.7 2.1 8.2e-05 22.5 0.0 6.4 6 0 0 6 6 5 3 HEAT repeat HEAT_EZ PF13513.6 PIK62987.1 - 1.7e-13 50.7 1.0 3.5e-10 40.2 0.1 5.5 6 0 0 6 6 5 1 HEAT-like repeat HEAT_2 PF13646.6 PIK62987.1 - 3.2e-13 49.9 0.7 9e-08 32.4 0.0 5.9 7 1 0 7 7 7 2 HEAT repeats Importin_rep_6 PF18829.1 PIK62987.1 - 1.5e-12 47.6 2.8 4.4e-12 46.1 0.9 2.8 2 0 0 2 2 2 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 PIK62987.1 - 2.3e-09 37.7 1.9 5.5e-07 30.1 0.0 5.0 6 1 1 7 7 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 PIK62987.1 - 4.8e-06 26.7 0.0 0.037 14.1 0.0 3.7 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 PIK62987.1 - 7.4e-06 25.3 0.1 0.1 11.7 0.1 4.2 4 1 1 5 5 5 2 Interferon-related developmental regulator (IFRD) Adaptin_N PF01602.20 PIK62987.1 - 0.0001 21.1 0.1 0.0038 15.9 0.0 2.5 2 0 0 2 2 2 1 Adaptin N terminal region DUF3385 PF11865.8 PIK62987.1 - 0.0001 22.3 4.1 1.5 8.8 0.0 6.5 6 2 1 8 8 8 1 Domain of unknown function (DUF3385) IBN_N PF03810.19 PIK62987.1 - 0.0029 17.5 0.4 0.72 9.8 0.0 4.0 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_PBS PF03130.16 PIK62987.1 - 0.0035 17.9 0.4 1.1e+02 3.9 0.0 5.4 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat UME PF08064.13 PIK62987.1 - 0.015 15.2 0.3 2.7 7.9 0.1 4.0 3 1 0 3 3 3 0 UME (NUC010) domain Arm PF00514.23 PIK62987.1 - 0.075 13.1 0.9 0.46 10.6 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Peptidase_C50 PF03568.17 PIK62987.1 - 5.9 5.9 6.7 12 4.9 0.7 3.0 3 0 0 3 3 3 0 Peptidase family C50 ABC_tran PF00005.27 PIK62989.1 - 4.1e-21 75.9 0.0 1.3e-20 74.3 0.0 1.9 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK62989.1 - 1.4e-05 24.9 1.2 2.2e-05 24.3 1.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 PIK62989.1 - 0.0002 21.3 0.1 0.15 11.8 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 PIK62989.1 - 0.0071 15.8 0.2 0.14 11.5 0.2 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.14 PIK62989.1 - 0.059 12.6 0.0 0.15 11.3 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain MMR_HSR1 PF01926.23 PIK62989.1 - 0.063 13.4 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 PIK62989.1 - 0.068 12.8 0.1 0.27 10.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 PIK62989.1 - 0.096 13.2 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 PIK62989.1 - 0.099 12.5 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 PIK62989.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 PIK62989.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 PIK62989.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Dynamin family E1-E2_ATPase PF00122.20 PIK62989.1 - 0.2 11.2 1.4 0.4 10.2 1.4 1.4 1 0 0 1 1 1 0 E1-E2 ATPase BNR_2 PF13088.6 PIK62990.1 - 3.3e-35 121.8 0.0 4.1e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 PIK62990.1 - 2.1e-10 40.4 0.0 3.4e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 PIK62990.1 - 0.00016 21.1 24.4 0.028 14.4 0.4 5.8 5 0 0 5 5 5 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 PIK62990.1 - 0.0031 16.3 0.1 0.72 8.6 0.0 2.6 1 1 2 3 3 3 3 Sortilin, neurotensin receptor 3, CyRPA PF18638.1 PIK62990.1 - 0.038 13.2 0.7 4 6.5 0.0 3.5 3 1 1 4 4 4 0 Cysteine-Rich Protective Antigen 6 bladed domain BNR_6 PF15899.5 PIK62990.1 - 0.092 12.9 3.7 7.9 6.8 0.2 3.7 3 0 0 3 3 3 0 BNR-Asp box repeat ABC_tran PF00005.27 PIK62991.1 - 1.1e-23 84.3 0.0 2.2e-22 80.0 0.0 2.4 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 PIK62991.1 - 2.3e-23 83.2 9.8 3.9e-23 82.5 9.8 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 PIK62991.1 - 3.8e-06 26.5 0.0 3.8e-06 26.5 0.0 1.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain IPTL-CTERM PF18203.1 PIK62991.1 - 2 8.4 6.5 4.4 7.3 6.5 1.6 1 0 0 1 1 1 0 IPTL-CTERM motif STAG PF08514.11 PIK62992.1 - 1.6e-37 127.9 2.1 7.5e-37 125.7 0.5 2.6 2 0 0 2 2 2 1 STAG domain DUF4441 PF14536.6 PIK62992.1 - 0.11 12.7 4.4 2.8 8.2 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) Med30 PF11315.8 PIK62992.1 - 0.35 11.1 5.8 18 5.5 1.1 3.7 3 0 0 3 3 3 0 Mediator complex subunit 30 Tho2 PF11262.8 PIK62992.1 - 4.4 6.4 7.9 3.2 6.9 0.7 3.3 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 TAA-Trp-ring PF15401.6 PIK62993.1 - 0.023 15.2 0.9 0.032 14.7 0.9 1.2 1 0 0 1 1 1 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin OAD_gamma PF04277.13 PIK62993.1 - 0.042 14.4 0.4 0.1 13.2 0.3 1.6 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain UPF0114 PF03350.16 PIK62993.1 - 0.13 12.5 0.3 0.19 12.0 0.3 1.4 1 1 0 1 1 1 0 Uncharacterized protein family, UPF0114 Y_phosphatase PF00102.27 PIK62994.1 - 2.5e-20 73.0 0.3 2.3e-12 47.0 0.1 2.7 1 1 1 2 2 2 2 Protein-tyrosine phosphatase ATP-gua_PtransN PF02807.15 PIK62994.1 - 0.033 14.6 0.2 10 6.6 0.0 2.5 2 0 0 2 2 2 0 ATP:guanido phosphotransferase, N-terminal domain PHB_acc_N PF07879.11 PIK62994.1 - 0.037 14.1 1.6 1.9 8.6 0.1 2.4 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain DUF4781 PF16013.5 PIK62994.1 - 0.046 12.5 1.4 0.15 10.8 0.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4781) CDH1_2_SANT_HL1 PF18375.1 PIK62995.1 - 0.21 12.3 3.2 0.14 12.8 0.7 2.0 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 RT_RNaseH PF17917.1 PIK62997.1 - 1.3e-19 70.4 0.2 9.9e-16 57.9 0.2 2.2 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 PIK62997.1 - 2.5e-19 69.2 0.0 3.1e-12 46.4 0.0 2.4 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase fn3 PF00041.21 PIK62998.1 - 1e-05 25.8 1.5 2.5e-05 24.5 1.5 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF1065 PF06358.11 PIK62998.1 - 6.7e-05 22.8 0.1 0.075 13.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1065) Ufm1 PF03671.14 PIK62998.1 - 0.001 19.1 0.0 0.97 9.6 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin fold modifier 1 protein DUF4164 PF13747.6 PIK62998.1 - 0.16 12.2 0.4 8.4 6.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Y_phosphatase PF00102.27 PIK63000.1 - 7.5e-54 182.8 0.0 3.8e-47 160.8 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Cadherin PF00028.17 PIK63001.1 - 4.3e-57 190.5 21.0 1.8e-15 57.2 0.1 9.2 9 1 0 9 9 9 8 Cadherin domain Cadherin_2 PF08266.12 PIK63001.1 - 0.001 18.8 0.0 0.2 11.5 0.0 3.7 4 0 0 4 4 4 1 Cadherin-like He_PIG PF05345.12 PIK63001.1 - 0.088 13.0 6.5 6 7.1 0.3 5.3 4 1 0 4 4 4 0 Putative Ig domain Tmemb_55A PF09788.9 PIK63002.1 - 4.2e-86 288.0 14.5 5e-86 287.8 14.5 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zinc_ribbon_12 PF11331.8 PIK63002.1 - 0.03 14.1 0.8 0.03 14.1 0.8 3.6 3 1 0 3 3 3 0 Probable zinc-ribbon domain Phage_holin_3_6 PF07332.11 PIK63002.1 - 0.14 12.2 4.0 0.2 11.7 4.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3040 PF11239.8 PIK63002.1 - 0.44 10.9 2.6 0.7 10.2 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) 60KD_IMP PF02096.20 PIK63003.1 - 3.6e-29 101.8 5.7 4.8e-29 101.4 5.7 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein p25-alpha PF05517.12 PIK63004.1 - 1.4e-46 158.5 10.5 1.6e-46 158.3 10.5 1.0 1 0 0 1 1 1 1 p25-alpha MIP PF00230.20 PIK63005.1 - 2.8e-69 233.3 10.5 3.3e-69 233.1 10.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein Arm PF00514.23 PIK63006.1 - 3.5e-08 33.2 4.4 0.0011 19.0 0.1 4.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 PIK63006.1 - 5.2e-06 26.8 2.9 0.57 10.7 0.1 4.5 4 1 0 4 4 4 3 HEAT-like repeat HEAT PF02985.22 PIK63006.1 - 0.00025 21.0 5.4 5.5 7.5 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 PIK63006.1 - 0.00027 21.3 1.2 0.031 14.6 0.3 3.2 1 1 2 3 3 3 1 HEAT repeats Calx-beta PF03160.14 PIK63007.1 - 1.2e-07 31.8 4.3 2.6e-07 30.7 4.3 1.6 1 0 0 1 1 1 1 Calx-beta domain Lectin_C PF00059.21 PIK63007.1 - 2.6e-07 31.3 0.0 5.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Cadherin-like PF12733.7 PIK63007.1 - 0.034 14.7 2.3 0.034 14.7 2.3 2.3 2 1 1 3 3 3 0 Cadherin-like beta sandwich domain UL45 PF05473.12 PIK63007.1 - 0.054 13.1 0.2 0.098 12.3 0.2 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 PIK63007.1 - 0.056 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Extracellular link domain SBF2 PF12335.8 PIK63008.1 - 1.6e-07 31.2 3.2 5.9e-07 29.3 3.2 1.8 1 1 0 1 1 1 1 Myotubularin protein HA2 PF04408.23 PIK63009.1 - 1.2e-22 80.2 0.0 2.8e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 PIK63009.1 - 3.2e-17 62.7 0.0 7.2e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 PIK63009.1 - 6.6e-15 55.4 0.0 1.8e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 PIK63009.1 - 4.4e-06 26.6 0.0 1.1e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 PIK63009.1 - 0.00017 21.8 0.0 0.00061 20.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain Metal_resist PF13801.6 PIK63009.1 - 0.017 15.3 0.6 8.8 6.5 0.0 2.7 3 0 0 3 3 3 0 Heavy-metal resistance AAA_30 PF13604.6 PIK63009.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 PIK63009.1 - 0.053 14.0 0.2 0.2 12.2 0.1 1.9 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 PIK63009.1 - 0.095 12.2 0.2 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 PIK63009.1 - 0.098 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 PIK63009.1 - 0.15 11.4 0.0 7.6 5.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family CK2S PF15011.6 PIK63010.1 - 2.8e-20 72.8 2.7 4.1e-20 72.3 2.7 1.2 1 0 0 1 1 1 1 Casein Kinase 2 substrate PRELI PF04707.14 PIK63011.1 - 1.9e-49 167.5 0.0 6.2e-49 165.8 0.0 1.6 1 1 1 2 2 2 1 PRELI-like family Metallophos PF00149.28 PIK63012.1 - 7.5e-11 42.9 0.9 1.8e-10 41.7 0.9 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 PIK63012.1 - 7.3e-07 29.5 0.5 2.3e-06 27.9 0.5 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 PIK63012.1 - 0.00018 20.9 0.0 0.00029 20.3 0.0 1.2 1 0 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily Sigma70_r1_1 PF03979.14 PIK63012.1 - 0.17 12.0 0.2 0.65 10.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Acyl_transf_3 PF01757.22 PIK63013.1 - 2.7e-14 53.0 44.0 2.7e-14 53.0 44.0 1.9 3 0 0 3 3 3 1 Acyltransferase family zf-H2C2_2 PF13465.6 PIK63015.1 - 6.1e-41 137.1 62.1 1.2e-09 38.1 0.6 8.9 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK63015.1 - 3.2e-26 90.3 65.2 0.00013 22.2 2.7 8.6 9 0 0 9 9 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK63015.1 - 2.2e-25 87.1 54.2 0.0015 19.2 0.2 8.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-H2C2_5 PF13909.6 PIK63015.1 - 3.4e-11 42.7 19.2 1.8e-07 30.7 4.6 7.9 9 1 0 9 9 8 4 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 PIK63015.1 - 4.8e-08 33.1 34.0 0.003 17.8 0.1 7.3 8 0 0 8 8 7 6 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 PIK63015.1 - 6.9e-05 23.1 39.3 0.056 13.7 2.9 5.3 2 2 2 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 PIK63015.1 - 0.039 14.3 42.0 9.7 6.6 9.9 7.3 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) DDE_Tnp_ISAZ013 PF07592.11 PIK63015.1 - 0.067 12.2 2.7 0.65 8.9 0.1 2.3 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain Rad50_zn_hook PF04423.14 PIK63015.1 - 0.86 9.5 5.2 15 5.5 0.1 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif TRAF6_Z2 PF18048.1 PIK63015.1 - 0.97 9.6 13.5 0.15 12.1 1.7 4.3 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 YlzJ PF14035.6 PIK63015.1 - 1.1 9.5 4.3 1.2 9.4 0.1 3.1 2 1 2 4 4 4 0 YlzJ-like protein Band_7_C PF16200.5 PIK63016.1 - 0.1 12.7 4.0 0.32 11.1 0.0 3.2 3 2 0 3 3 3 0 C-terminal region of band_7 zf-H2C2_2 PF13465.6 PIK63017.1 - 7.2e-21 73.6 63.3 3.2e-07 30.5 1.1 10.0 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.26 PIK63017.1 - 1.9e-12 46.9 78.7 0.026 15.0 1.9 8.9 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK63017.1 - 1.3e-08 35.0 74.4 0.17 12.8 0.6 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_6 PF13912.6 PIK63017.1 - 0.0033 17.4 3.0 0.0033 17.4 3.0 7.4 8 0 0 8 8 8 4 C2H2-type zinc finger zf-met PF12874.7 PIK63017.1 - 0.033 14.6 0.8 0.033 14.6 0.8 7.4 6 1 0 7 7 7 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 PIK63017.1 - 0.055 13.4 21.2 0.057 13.3 0.0 5.8 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 PIK63017.1 - 0.092 13.1 0.2 0.092 13.1 0.2 8.5 8 1 1 9 9 9 0 Zinc-finger double-stranded RNA-binding MarB PF13999.6 PIK63017.1 - 0.18 11.7 0.1 0.48 10.3 0.1 1.7 2 0 0 2 2 2 0 MarB protein zinc_ribbon_15 PF17032.5 PIK63017.1 - 5.4 7.8 26.6 5.9 7.7 2.0 5.2 5 0 0 5 5 5 0 zinc-ribbon family zf-H2C2_2 PF13465.6 PIK63018.1 - 1e-23 82.6 35.6 2e-07 31.1 0.9 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 PIK63018.1 - 1.9e-22 78.4 38.1 1.2e-05 25.5 0.2 5.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK63018.1 - 8.2e-20 69.8 34.6 0.00024 21.7 0.2 5.2 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 PIK63018.1 - 3.5e-11 43.1 31.6 0.0016 18.7 0.5 5.4 4 1 1 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 PIK63018.1 - 3.9e-10 39.8 29.8 0.0096 16.3 3.0 5.3 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 PIK63018.1 - 6.2e-05 22.9 32.7 0.12 12.4 1.9 5.7 5 1 0 5 5 5 3 C2H2-type zinc finger zf-Di19 PF05605.12 PIK63018.1 - 9.6e-05 22.6 23.4 0.016 15.5 7.2 3.4 1 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 PIK63018.1 - 0.00026 21.1 21.0 0.23 11.7 0.5 5.3 5 0 0 5 5 5 2 AN1-like Zinc finger PyrI_C PF02748.15 PIK63018.1 - 0.0011 18.8 18.3 0.076 12.9 3.8 4.3 3 1 1 4 4 4 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain BolA PF01722.18 PIK63018.1 - 0.0012 19.0 6.5 0.025 14.8 1.4 3.1 1 1 2 3 3 3 1 BolA-like protein Endonuc_subdom PF09062.10 PIK63018.1 - 0.0037 18.0 1.8 1.3 9.9 0.1 3.1 1 1 1 2 2 2 1 PI-PfuI Endonuclease subdomain zf-C2HC_2 PF13913.6 PIK63018.1 - 0.0057 16.5 26.0 0.04 13.8 0.3 5.4 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-BED PF02892.15 PIK63018.1 - 0.01 15.8 21.3 0.2 11.7 4.5 4.4 1 1 3 4 4 4 0 BED zinc finger zf-C2H2_2 PF12756.7 PIK63018.1 - 0.023 15.0 30.0 1.2 9.5 0.3 5.0 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 PIK63018.1 - 0.06 14.1 20.3 2.2 9.1 12.1 3.0 1 1 1 2 2 2 0 zinc-ribbon family Baculo_IE-1 PF05290.11 PIK63018.1 - 0.073 13.0 0.8 0.073 13.0 0.8 3.6 1 1 3 4 4 4 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_9 PF16293.5 PIK63018.1 - 0.1 12.5 10.9 0.42 10.5 0.7 3.6 3 1 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf_UBZ PF18439.1 PIK63018.1 - 0.19 11.3 18.8 0.41 10.3 0.2 5.2 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-MYST PF17772.1 PIK63018.1 - 0.23 11.1 18.9 2.5 7.8 0.2 4.5 3 2 2 5 5 5 0 MYST family zinc finger domain Zf_RING PF16744.5 PIK63018.1 - 0.26 11.4 15.8 6.6 6.9 0.2 4.1 1 1 3 4 4 4 0 KIAA1045 RING finger C1_4 PF07975.12 PIK63018.1 - 0.27 11.5 26.0 0.62 10.3 0.9 3.9 1 1 4 5 5 5 0 TFIIH C1-like domain PriA_CRR PF18319.1 PIK63018.1 - 0.59 10.2 0.2 0.59 10.2 0.2 4.8 5 0 0 5 5 5 0 PriA DNA helicase Cys-rich region (CRR) domain HNH_5 PF14279.6 PIK63018.1 - 0.75 9.7 23.9 9.7 6.1 0.6 5.1 5 0 0 5 5 5 0 HNH endonuclease Zn_Tnp_IS1595 PF12760.7 PIK63018.1 - 0.87 9.6 22.6 0.084 12.9 1.8 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain C1_2 PF03107.16 PIK63018.1 - 2.1 8.7 27.0 1.6 9.1 0.3 5.0 1 1 3 4 4 4 0 C1 domain zf-HIT PF04438.16 PIK63018.1 - 3.1 7.8 19.5 3 7.8 0.5 4.8 5 0 0 5 5 5 0 HIT zinc finger zf-nanos PF05741.13 PIK63018.1 - 4.1 7.7 23.4 0.97 9.7 1.9 4.7 3 3 0 3 3 3 0 Nanos RNA binding domain zf-C2H2 PF00096.26 PIK63019.1 - 5.3e-10 39.2 8.2 7.2e-06 26.2 1.2 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 PIK63019.1 - 1.6e-08 34.6 7.1 0.00058 20.5 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 PIK63019.1 - 5.2e-08 33.0 10.4 8.6e-08 32.3 0.6 2.7 3 0 0 3 3 2 2 Zinc-finger double domain zf-met PF12874.7 PIK63019.1 - 5.4e-06 26.6 6.2 0.004 17.5 1.5 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK63019.1 - 1.6e-05 25.1 3.9 0.0043 17.3 1.4 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK63019.1 - 0.00055 19.9 8.7 0.013 15.5 0.7 2.7 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 PIK63019.1 - 0.027 14.2 2.9 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type FYVE PF01363.21 PIK63019.1 - 0.055 13.6 1.7 0.1 12.8 1.7 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-Di19 PF05605.12 PIK63019.1 - 0.093 13.0 2.5 0.15 12.3 2.5 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 PIK63019.1 - 0.24 11.3 3.1 6.1 6.9 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 PIK63019.1 - 0.31 11.5 3.9 1.6 9.2 0.2 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 PIK63019.1 - 0.55 10.6 5.4 0.77 10.1 0.8 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zf_RING PF16744.5 PIK63019.1 - 0.59 10.3 2.7 4.4 7.5 0.1 2.3 1 1 1 2 2 2 0 KIAA1045 RING finger C1_2 PF03107.16 PIK63019.1 - 0.66 10.3 3.0 11 6.4 3.0 2.4 1 1 0 1 1 1 0 C1 domain zf-BED PF02892.15 PIK63019.1 - 0.82 9.7 6.6 7.7 6.6 0.5 2.4 1 1 1 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.6 PIK63020.1 - 1.6e-18 66.2 27.9 2.2e-07 31.0 0.5 5.7 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 PIK63020.1 - 1.3e-17 62.9 42.5 0.00045 20.8 0.9 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 PIK63020.1 - 2.2e-17 62.5 42.9 1.4e-05 25.3 1.2 6.6 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-met PF12874.7 PIK63020.1 - 1e-10 41.6 35.1 0.0017 18.7 0.1 6.5 7 0 0 7 7 6 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 PIK63020.1 - 1.8e-09 37.6 33.0 0.00096 19.4 0.2 6.8 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 PIK63020.1 - 3.7e-05 23.6 28.9 0.17 11.9 0.7 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2HC_2 PF13913.6 PIK63020.1 - 0.02 14.8 18.3 0.21 11.5 0.2 4.7 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 PIK63020.1 - 0.1 12.9 33.8 0.14 12.5 2.3 6.5 3 2 2 6 6 6 0 C2H2 type zinc-finger (2 copies) DUF2225 PF09986.9 PIK63020.1 - 0.12 12.1 1.6 1.1 9.0 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Vps36-NZF-N PF16988.5 PIK63020.1 - 2 7.9 4.9 42 3.6 0.9 3.7 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PHF5 PF03660.14 PIK63020.1 - 5.5 7.2 11.0 4.5 7.5 0.5 3.4 4 0 0 4 4 4 0 PHF5-like protein Desulfoferrod_N PF06397.12 PIK63020.1 - 7.3 6.3 12.6 2.1 8.1 0.3 3.1 3 0 0 3 3 2 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_8 PF15909.5 PIK63020.1 - 9.4 6.6 16.7 0.23 11.8 0.6 3.9 4 1 1 5 5 4 0 C2H2-type zinc ribbon MCM PF00493.23 PIK63021.1 - 1.4e-98 328.5 0.0 2e-98 328.0 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 PIK63021.1 - 6.4e-38 129.5 0.2 1.2e-37 128.6 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 PIK63021.1 - 9.1e-26 90.1 0.7 2.2e-25 88.9 0.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 PIK63021.1 - 1.8e-17 63.8 0.9 7.5e-17 61.8 0.9 2.1 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 PIK63021.1 - 6.3e-09 35.9 0.1 3.5e-08 33.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 PIK63021.1 - 6e-08 32.3 0.0 4.7e-05 22.9 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 PIK63021.1 - 4.3e-05 23.4 0.0 0.00011 22.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 PIK63021.1 - 0.0061 16.3 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA PF00004.29 PIK63021.1 - 0.012 16.0 0.0 0.042 14.3 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK63021.1 - 0.061 13.6 1.0 2.9 8.1 0.0 3.1 2 2 1 3 3 3 0 AAA domain Elf1 PF05129.13 PIK63021.1 - 0.28 11.3 1.4 1.2 9.3 0.7 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like UPF0175 PF03683.13 PIK63021.1 - 0.63 9.8 2.4 11 5.8 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0175) MT-A70 PF05063.14 PIK63022.1 - 5e-35 121.0 0.2 1.4e-34 119.5 0.2 1.8 1 0 0 1 1 1 1 MT-A70 2Fe-2S_thioredx PF01257.19 PIK63023.1 - 2.4e-62 209.1 0.1 3e-62 208.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin VPS9 PF02204.18 PIK63024.1 - 5.8e-23 81.1 0.2 1.2e-21 76.9 0.0 2.6 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF2935 PF11155.8 PIK63024.1 - 0.066 13.5 0.8 3.4 8.0 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) MIT PF04212.18 PIK63024.1 - 0.068 13.3 0.1 0.068 13.3 0.1 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Glutaredoxin2_C PF04399.13 PIK63024.1 - 0.22 11.3 2.6 11 5.8 0.0 3.6 3 1 0 3 3 3 0 Glutaredoxin 2, C terminal domain YqfD PF06898.11 PIK63024.1 - 0.96 8.2 7.0 0.7 8.7 0.4 2.2 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD DUF4806 PF16064.5 PIK63024.1 - 2.9 8.2 4.7 1.9 8.8 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) DUF1077 PF06417.12 PIK63025.1 - 5e-44 149.1 3.5 6.9e-44 148.6 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) HYR PF02494.16 PIK63026.1 - 2e-22 79.3 2.0 1.3e-10 41.4 0.2 2.3 2 0 0 2 2 2 2 HYR domain CUB PF00431.20 PIK63026.1 - 8.2e-08 32.6 0.0 4.5e-06 27.0 0.0 2.9 2 2 1 3 3 3 1 CUB domain DUF5011 PF16403.5 PIK63026.1 - 0.0023 18.0 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5011) RVT_1 PF00078.27 PIK63027.1 - 1.7e-28 99.7 0.1 2.3e-28 99.2 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zona_pellucida PF00100.23 PIK63028.1 - 3.5e-21 76.2 1.2 3.5e-21 76.2 1.2 1.7 2 0 0 2 2 2 1 Zona pellucida-like domain Zona_pellucida PF00100.23 PIK63029.1 - 6e-43 147.5 5.1 6e-43 147.5 5.1 1.5 2 0 0 2 2 2 1 Zona pellucida-like domain AAA_12 PF13087.6 PIK63030.1 - 9.6e-29 100.4 0.1 4.1e-28 98.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK63030.1 - 0.0029 17.4 0.1 0.0076 16.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain RVT_1 PF00078.27 PIK63031.1 - 9.6e-29 100.5 0.0 1.9e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 PIK63031.1 - 0.0001 22.0 0.2 0.0012 18.5 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain rve PF00665.26 PIK63031.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain PIN_5 PF08745.11 PIK63031.1 - 0.081 12.3 0.3 0.39 10.1 0.1 2.1 2 0 0 2 2 2 0 PINc domain ribonuclease AAA_11 PF13086.6 PIK63032.1 - 2.5e-05 24.2 3.0 6.7e-05 22.8 3.3 1.6 1 1 0 1 1 1 1 AAA domain Complex1_LYR_2 PF13233.6 PIK63032.1 - 0.06 14.1 3.8 7.5 7.4 0.6 3.1 2 1 0 2 2 2 0 Complex1_LYR-like AAA_11 PF13086.6 PIK63033.1 - 1.8e-12 47.6 0.0 2.9e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 PIK63033.1 - 3.8e-08 33.8 0.0 1.1e-06 29.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 PIK63033.1 - 1.5e-05 24.8 0.0 9.3e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 PIK63033.1 - 6.1e-05 23.1 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 PIK63033.1 - 0.0009 18.6 0.1 0.002 17.5 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 PIK63033.1 - 0.009 15.5 0.0 0.022 14.2 0.0 1.6 2 0 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 PIK63033.1 - 0.012 15.1 0.0 0.1 12.1 0.0 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 PIK63033.1 - 0.013 15.8 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 PIK63033.1 - 0.15 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_12 PF13087.6 PIK63034.1 - 5.7e-08 32.6 0.2 1.6e-07 31.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain PPR PF01535.20 PIK63036.1 - 0.38 11.1 1.6 39 4.8 0.1 2.7 2 0 0 2 2 2 0 PPR repeat AAA_12 PF13087.6 PIK63037.1 - 6.4e-36 123.9 0.0 1.7e-35 122.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 PIK63037.1 - 8.2e-15 55.3 0.3 1.5e-14 54.5 0.3 1.4 1 0 0 1 1 1 1 AAA domain CheB_methylest PF01339.17 PIK63037.1 - 0.0047 16.7 0.1 0.007 16.1 0.1 1.2 1 0 0 1 1 1 1 CheB methylesterase AAA_30 PF13604.6 PIK63037.1 - 0.016 15.0 0.1 0.03 14.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 PIK63037.1 - 0.096 13.0 0.0 0.22 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain CPSF_A PF03178.15 PIK63040.1 - 4.2e-49 167.6 0.8 7.7e-35 120.7 0.0 4.4 4 1 1 5 5 5 3 CPSF A subunit region MMS1_N PF10433.9 PIK63040.1 - 7.8e-38 130.3 0.0 3e-36 125.1 0.0 2.3 1 1 1 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF4964 PF16334.5 PIK63040.1 - 0.1 12.1 0.1 1.7 8.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4964) Trypan_PARP PF05887.11 PIK63040.1 - 1.6 8.7 3.4 1.3 9.0 0.8 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SNARE PF05739.19 PIK63041.1 - 1.2e-20 73.2 1.9 3.4e-20 71.8 1.9 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 PIK63041.1 - 3e-06 27.1 12.8 3e-06 27.1 12.8 2.1 2 0 0 2 2 2 1 Syntaxin MCPsignal PF00015.21 PIK63041.1 - 0.0056 16.5 1.4 0.0056 16.5 1.4 2.4 2 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF5345 PF17280.2 PIK63041.1 - 0.012 15.6 2.2 0.096 12.7 0.5 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5345) DUF2116 PF09889.9 PIK63041.1 - 0.032 14.2 3.1 0.074 13.0 3.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Syntaxin_2 PF14523.6 PIK63041.1 - 0.092 13.1 14.0 0.039 14.3 2.6 2.4 2 0 0 2 2 2 0 Syntaxin-like protein VWA_2 PF13519.6 PIK63041.1 - 0.12 13.0 3.4 0.24 12.1 0.6 2.6 3 0 0 3 3 3 0 von Willebrand factor type A domain Laminin_II PF06009.12 PIK63041.1 - 0.4 10.7 8.0 0.57 10.2 0.5 2.7 2 1 0 2 2 2 0 Laminin Domain II CENP-K PF11802.8 PIK63041.1 - 0.49 9.9 14.2 0.95 9.0 12.6 1.8 1 1 1 2 2 2 0 Centromere-associated protein K Synaptobrevin PF00957.21 PIK63041.1 - 0.52 10.1 12.5 0.067 13.0 6.8 2.5 2 1 0 2 2 2 0 Synaptobrevin CCDC-167 PF15188.6 PIK63041.1 - 0.61 10.5 7.2 1.6 9.1 1.8 3.1 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 Orf78 PF06024.12 PIK63041.1 - 0.85 10.0 3.9 0.41 11.0 0.8 2.1 2 0 0 2 2 2 0 Orf78 (ac78) ETRAMP PF09716.10 PIK63041.1 - 0.95 9.6 3.8 1.5 8.9 3.8 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TMPIT PF07851.13 PIK63041.1 - 2.9 7.1 12.0 2.2 7.4 2.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein T2SSF PF00482.23 PIK63041.1 - 3.1 7.8 6.6 3.5 7.6 4.0 2.4 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF1676 PF07898.13 PIK63041.1 - 4 7.4 7.4 7.1 6.6 4.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1676) RT_RNaseH_2 PF17919.1 PIK63042.1 - 2e-34 117.6 0.0 5.8e-34 116.1 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 PIK63042.1 - 1.1e-29 102.8 0.0 2e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 PIK63042.1 - 1.4e-15 57.4 0.0 6.3e-13 48.8 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 PIK63042.1 - 5.9e-12 45.5 0.2 1.6e-11 44.1 0.0 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 PIK63042.1 - 4.1e-11 43.1 0.0 9.1e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 PIK63042.1 - 0.0085 15.8 0.0 0.023 14.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 PIK63042.1 - 0.043 14.0 0.0 0.093 13.0 0.0 1.6 1 0 0 1 1 1 0 DDE domain zf-H2C2 PF09337.10 PIK63042.1 - 0.051 13.8 0.0 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 H2C2 zinc finger Redoxin PF08534.10 PIK63042.1 - 0.18 11.5 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Redoxin Stress-antifung PF01657.17 PIK63043.1 - 0.0036 17.9 0.2 0.0044 17.6 0.2 1.3 1 0 0 1 1 1 1 Salt stress response/antifungal TPR_19 PF14559.6 PIK63043.1 - 0.077 13.5 0.2 0.18 12.3 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 PIK63043.1 - 0.089 13.2 0.2 0.089 13.2 0.2 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TPR_8 PF13181.6 PIK63043.1 - 0.19 12.0 3.8 2 8.9 0.3 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 PIK63045.1 - 2.7e-30 105.6 0.0 9e-16 58.0 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 PIK63045.1 - 2.8e-15 56.3 0.0 5.3e-09 35.7 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 PIK63045.1 - 0.0025 17.2 0.0 0.028 13.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Med24_N PF11277.8 PIK63046.1 - 1.7e-149 499.8 33.5 8.2e-100 335.4 20.9 4.1 2 1 1 3 3 3 3 Mediator complex subunit 24 N-terminal TC1 PF15063.6 PIK63046.1 - 0.098 12.5 0.3 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 Thyroid cancer protein 1 Pkinase PF00069.25 PIK63047.1 - 1.3e-16 60.8 0.0 4e-16 59.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK63047.1 - 7.5e-09 35.2 0.0 2.9e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 PIK63047.1 - 2.5e-05 23.7 0.0 4.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 PIK63047.1 - 0.00044 19.9 0.0 0.00068 19.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family SMG1_N PF17229.2 PIK63047.1 - 0.073 13.8 1.0 0.16 12.7 0.1 1.9 2 0 0 2 2 2 0 Serine/threonine-protein kinase SMG1 N-terminal Phage_integrase PF00589.22 PIK63049.1 - 0.00045 20.1 0.0 0.00067 19.5 0.0 1.3 2 0 0 2 2 2 1 Phage integrase family HEAT PF02985.22 PIK63051.1 - 7.8e-15 53.7 14.1 0.0014 18.8 0.0 7.5 7 0 0 7 7 7 5 HEAT repeat HEAT_2 PF13646.6 PIK63051.1 - 2.3e-06 27.9 0.1 2.1 8.8 0.0 5.0 2 2 3 6 6 6 3 HEAT repeats MinC_N PF05209.13 PIK63051.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain Band_7_C PF16200.5 PIK63052.1 - 9.2e-05 22.4 53.4 2.6 8.2 1.4 10.2 1 1 13 14 14 14 13 C-terminal region of band_7 TrpP PF17099.5 PIK63052.1 - 0.0025 17.6 25.4 1.2 8.9 1.4 5.4 1 1 8 9 9 9 9 Tryptophan transporter TrpP NACHT PF05729.12 PIK63053.1 - 6.7e-12 45.6 0.1 2.3e-11 43.9 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 PIK63053.1 - 7.4e-06 26.5 0.1 3.6e-05 24.2 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.15 PIK63053.1 - 0.0039 17.2 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 PIK63053.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain ATPase_2 PF01637.18 PIK63053.1 - 0.027 14.4 0.1 0.3 11.0 0.0 2.9 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea ANAPC4_WD40 PF12894.7 PIK63053.1 - 0.034 14.4 0.3 0.82 10.0 0.0 3.1 3 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain AAA PF00004.29 PIK63053.1 - 0.036 14.5 0.0 0.11 12.9 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 PIK63053.1 - 0.052 13.8 0.0 0.14 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 PIK63053.1 - 0.063 12.8 0.1 0.16 11.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region WD40 PF00400.32 PIK63053.1 - 0.64 11.0 8.8 15 6.6 0.1 5.2 5 0 0 5 5 5 0 WD domain, G-beta repeat Pkinase PF00069.25 PIK63054.1 - 8.6e-74 248.2 0.0 1e-73 248.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 PIK63054.1 - 4.1e-32 111.5 0.0 5.4e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 PIK63054.1 - 1.4e-05 24.6 0.0 0.00026 20.4 0.0 2.5 1 1 1 3 3 3 1 Kinase-like APH PF01636.23 PIK63054.1 - 0.0023 17.9 0.0 0.39 10.6 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 PIK63054.1 - 0.0028 17.3 0.2 1.5 8.4 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 PIK63054.1 - 0.024 14.0 0.4 0.062 12.7 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gln-synt_C PF00120.24 PIK63055.1 - 1e-54 185.9 0.0 1.8e-54 185.1 0.0 1.3 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Terminase_3 PF04466.13 PIK63057.1 - 0.0088 15.6 0.2 0.01 15.4 0.2 1.1 1 0 0 1 1 1 1 Phage terminase large subunit DUF1664 PF07889.12 PIK63057.1 - 0.017 15.2 2.3 0.8 9.7 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 PIK63057.1 - 0.025 14.9 1.8 0.086 13.1 0.6 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AIP3 PF03915.13 PIK63057.1 - 0.039 13.1 6.2 0.46 9.5 1.5 2.0 1 1 1 2 2 2 0 Actin interacting protein 3 DUF948 PF06103.11 PIK63057.1 - 0.12 12.7 0.3 0.39 11.0 0.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.11 PIK63057.1 - 0.15 12.7 2.2 1.5 9.4 0.5 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal NPV_P10 PF05531.12 PIK63057.1 - 0.35 11.4 3.0 4.9 7.7 3.0 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Beta-lactamase PF00144.24 PIK63058.1 - 1.4e-32 113.2 0.0 1.9e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase BTRD1 PF17660.1 PIK63058.1 - 8.6e-08 31.9 0.0 0.00019 21.2 0.0 2.8 2 0 0 2 2 2 2 Bacterial tandem repeat domain 1 CompInhib_SCIN PF11546.8 PIK63058.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Echinodermata/Apostichopus_japonicus-ASM275485v1/GCA_002754855.1_ASM275485v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Echinodermata/Apostichopus_japonicus-ASM275485v1/GCA_002754855.1_ASM275485v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Echinodermata/Apostichopus_japonicus-ASM275485v1/GCA_002754855.1_ASM275485v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Echinodermata/Apostichopus_japonicus-ASM275485v1/GCA_002754855.1_ASM275485v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 20:25:35 2019 # [ok]